gebhart/patrepeval huggingface dataset:
Note—Sequencing JIT Mixed-Model Assembly Lines (1991)

We provide a new formulation and solution procedure to sequence a mixed model just-in-time (JIT) assembly system. Mixed model JIT assembly systems are a fundamental part of the well-known “Toyota Production System.” The underlying idea in sequencing these systems is to maintain a constant usage rate of all parts on the line. We give a polynomial algorithm to determine the optimal sequence for an objective function that is mathematically different, but intuitively similar to the objective functions of previous researchers. Furthermore, a computational study indicates that the new algorithm is robust in that its sequences are as good as those generated by other algorithms when evaluated with respect to traditional objectives, but are found 200 times faster.
Papaverine and prostaglandin E1 gel applications for impotence. (1995)

The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 micrograms PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.
Morphologies of microphase-separated conformationally asymmetric diblock copolymers (1998)

The equilibrium morphological behavior of a series of conformationally asymmetric linear diblock copolymers is characterized via small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). The linear diblock molecules of polyisoprene and poly(t-butylmethacrylate) (PtBMA) are prepared anionically over a range of PtBMA volume fractions 0.17 to 0.85. Solution light-scattering experiments are performed on PtBMA homopolymer at theta conditions, and the results were compared with PI data in the literature in order to characterize the degree of conformational asymmetry between the respective blocks. This conformational asymmetry is quantified by an ε of 0.75. The experimental results are compared with morphological behavior calculated utilizing self-consistent mean field theory for a diblock system with ε = 0.75. At middle to high PtBMA volume fractions, ϕPtBMA > 0.30, the experimental morphological behavior agrees well with the calculated behavior; the microphase boundaries are slightly shifted to higher volume fractions of the PtBMA block due to its larger Kuhn length. At ϕPtBMA < 0.30, however, discrepancies are found in the volume fraction dependence of experimentally determined morphological behavior and that calculated theoretically. Interestingly, extremely well-ordered cylindrical microstructures were observed for PI cylinder domains embedded in PtBMA matrices; these samples were prepared by solvent casting with no treatment, such as shearing, to enhance long-range order. These well-ordered cylinder structures contrast with PtBMA cylinders in a PI matrix on the opposite side of the phase diagram that have very poor long-range order. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 2629–2643, 1997
In-slot Direct Cooling Design and Optimization for Electric Machines (2021)

This work strives to apply the in-slot direct cooling technique in electric machines and optimize the cooling design to improve the machine performance in both cooling and electromagnetic (EM) aspects. The in-slot cooling directly removes the heat from the heating source, but requires extra spaces in the slots that possibly reduce the electromagnetic performance of the machine. It needs an overall evaluation considering both EM and thermal performances to achieve an optimal machine design for in-slot cooling systems. This work utilizes a thermal-network based numerical modeling approach combined with finite element (FE) EM simulations to evaluate the proposed in-slot cooling scheme and compares it with a drip-cooled machine product from multiple aspects, such as torque output, temperature, efficiency and pump power. The thermal network model was verified with thermal FE simulations and is capable of predicting the transient temperature of the machine system. The temperature distribution and corresponding power losses of the electric machines with in-slot cooling designs were calculated on various machine operating points. The final efficiency of the in-slot cooled machine was compared with the drip-cooled machine. Then, an in-slot cooling design was chosen based on the simulation results and comparison for prototyping. Finally, a 3D printed prototype of a partial machine with in-slot cooling channels was designed and constructed to check the manufacturability of the proposed cooling design.
Possibility of Shielding the Fifth Force (1988)

Received 8 September 1987DOI:https://doi.org/10.1103/PhysRevLett.60.74©1988 American Physical Society
Kinetik des Metallaustausches bei Bis(salicylaldiminato)kupfer(II)‐Komplexen in Chloroform, I. Einfluß der Elektronendichte am Donorsauerstoff (1976)

Der Kupferaustausch zwischen 22 verschiedenen Bis(salicylaldiminato)kupfer(II)-Komplexen (CuL2) und Mono(pyridin)kupfer(II)-acetat (CuAc2py) wurde im Temperaturbereich 0-25°C durch Isotopenaustausch verfolgt, um den Einfluß von Substituenten in 3- und 5-Stellung zu studieren. In Chloroform gehorcht der Austausch Geschwindigkeitsgleichung (2). Diese ist in übereinstimmung mit einem Mechanismus. bei dem der Austauschschritt in der Reaktion einer Zwischenstufe CuL2′ des Komplexes mit monomerem CuAc2py besteht. Elektronenspendende bzw. -ziehende Substituenten in 5-Stellung erhöhen bzw. erniedrigen die Austauschgeschwindigkeit. Eine Auftragung nach Hammett liefert ρ = −1.3. Für die Bildung der Zwischenstufe CuL2′ wird Ringöffnung unter Spaltung einer Cu-O-Bindung diskutiert. Metal Exchange Kinetics of Bis(salicylaldiminato)copper(II) Complexes in Chloroform, I Influence of Donor Oxygen Electron Density The copper exchange between 22 different bis(salicylaldiminato)copper(II) complexes (CuL2) and mono(pyridine)copper(II) acetate (CuAc2py) was followed by isotopic exchange in the temperature range 0–25°C to study the influence of substituents in 3- and 5-position. In chloroform, the exchange obeys the rate law (2). It is in agreement with a mechanism involving the reaction of an intermediate CuL2′ with monomeric CuAc2py as the exchange-step. Electron releasing and withdrawing substituents in 5-position increase and decrease the rate of exchange, respectively. A Hammett plot yields ρ = −1.3. The formation of the intermediate CuL2′ is discussed on the basis of ring opening by rupture of a CuO-bond.
A New Shear-Tolerant High-Temperature Fracturing Fluid (2009)

Abstract The extent of crosslinking a polymeric fracturing gel can significantly contribute to the success or failure of a hydraulic fracturing treatment. In certain cases, excessive crosslinking while the fluid is in the tubulars can result in friction pressures that are too high, and may prohibit the treatment from achieving the design goals. With titanium (Ti) or zirconium (Zr) crosslinked gels, which are known to be prone to irreversible shear degradation, early crosslinking in the tubulars can substantially reduce the final gel strength, even to the degree that near wellbore proppant transport is compromised, and the treatment may screenout. On the other hand, a Ti or Zr crosslinked gel which crosslinks substantially after exiting the perforations may not have sufficient proppant transport capability to complete the treatment successfully. Varying treatment conditions such as mixwater composition and temperature, tubular shear rate and transit time, and reservoir temperature pose difficult challenges to routinely achieving the optimal crosslinking state. Conditions such as offshore wellbore temperature profiles and viscous heating in smaller diameter tubing can further complicate the task. Various chemical means have been employed to tune the crosslinking temperature for specific treating conditions. These methods involve addition of chemicals to control the crosslinking kinetics, such as pH buffers, crosslinker concentration, and competing ligands to temporarily bind the metal crosslinker. Blended crosslinkers containing a single Group 4 (Ti, Zr) metal with different organic ligands with different binding strengths have been employed to achieve crosslinking at two temperature ranges so that early viscosity for proppant transport can be developed. Mixed metal crosslinkers, such as aluminum and Zr have also been formulated for this same purpose. This paper examines the disadvantages of these strategies, and describes the development and deployment of a high-temperature fracturing fluid system that has shown to overcome those issues.
Jointly Learned Symbol Detection and Signal Reflection in RIS-Aided Multi-user MIMO Systems (2021)

Reconfigurable Intelligent Surfaces (RISs) are regarded as a key technology for future wireless communications, enabling programmable radio propagation environments. However, the passive reflecting feature of RISs induces notable challenges on channel estimation, making coherent symbol detection a challenging task. In this paper, we consider the uplink of RIS-aided multi-user Multiple-Input Multiple-Output (MIMO) systems and propose a Machine Learning (ML) approach to jointly design the multi-antenna receiver and configure the RIS reflection coefficients, which does not require explicit full knowledge of the channel input-output relationship. Our approach devises a ML-based receiver, while the configurations of the RIS reflection patterns affecting the underlying propagation channel are treated as hyperparameters. Based on this system design formulation, we propose a Bayesian ML framework for optimizing the RIS hyperparameters, according to which the transmitted pilots are directly used to jointly tune the RIS and the multi-antenna receiver. Our simulation results demonstrate the capability of the proposed approach to provide reliable communications in non-linear channel conditions corrupted by Gaussian noise.
1750: Prognostic Impact of Chromosomal Alterations in Renal cell Carcinoma Following Surgical Resection (2004)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 12, 2004, 8:00 am - 12:00 pm1 Apr 20041750: Prognostic Impact of Chromosomal Alterations in Renal cell Carcinoma Following Surgical Resection John S. Lam, Oleg Shvarts, P. Nagesh Rao, Xueli Liu, Gang Li, Carlyle Longhorn, Robert A. Figlin, Arie S. Belldegrun, and Allan J. Pantuck John S. LamJohn S. Lam More articles by this author , Oleg ShvartsOleg Shvarts More articles by this author , P. Nagesh RaoP. Nagesh Rao More articles by this author , Xueli LiuXueli Liu More articles by this author , Gang LiGang Li More articles by this author , Carlyle LonghornCarlyle Longhorn More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , Arie S. BelldegrunArie S. Belldegrun More articles by this author , and Allan J. PantuckAllan J. Pantuck More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38942-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1750: Prognostic Impact of Chromosomal Alterations in Renal cell Carcinoma Following Surgical Resection." The Journal of Urology, 171(4S), p. 463 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 463 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information John S. Lam More articles by this author Oleg Shvarts More articles by this author P. Nagesh Rao More articles by this author Xueli Liu More articles by this author Gang Li More articles by this author Carlyle Longhorn More articles by this author Robert A. Figlin More articles by this author Arie S. Belldegrun More articles by this author Allan J. Pantuck More articles by this author Expand All Advertisement Loading ...
Accurate modeling of RF passive component in deep submicron process (2010)

An accurate and effective modeling method suitable for on-chip passive components fabricated in deep submicron process is presented. The proposed model adopts expandable-stage resonators to effectively capture the characteristic behaviors of parasitic interferences which generated owing to component operating at higher frequency and distributed in the component itself and the substrate. As a result, it can model the actual operation characters of component accurately over the interesting frequency range. In order to extract the model efficient, a model extraction procedure with less computational resource cost is also presented. Finally, experiment at a 90 nm-process on-chip spiral inductor verifies the accuracy of proposed modeling method.
Identification of viral determinants involved in Borna Disease Virus interference with human neurogenesis (2012)

International audience
Optofluidic time-stretch microscopy for precision medicine (2018)

We present the principle of optofluidic time-stretch microscopy and its application to precision medicine. Its ability to perform multiparametric image-based profiling of numerous single cells enables biomedical data mining with the help of machine learning.
Induced Polarization (Ip) Measurements Of Soils From An Aged Hydrocarbon Contaminated Site (2003)

Products of hydrocarbon biodegradation are organic acids, CO2, and water. Organic acids and&lt;br&gt;carbonic acids formed from CO2 enhance soil dissolution. Therefore, biodegradation results in&lt;br&gt;enrichment of ions, increasing electrolyte concentration and changing fluid chemistry. Further,&lt;br&gt;dissolution is expected to induce physical changes in the surface area of soil particles, potentially&lt;br&gt;impacting their electrical response. To test the above hypothesis, induced polarization (IP)&lt;br&gt;measurements in the frequency range (0.1-1000 Hz) were made on samples from an aged hydrocarbon&lt;br&gt;contaminated site where intrinsic bioremediation occurs.&lt;br&gt;Results from the saturated zone indicate that real conductivity (σ&apos;) is unable to distinguish&lt;br&gt;contaminated from uncontaminated samples. However, using imaginary conductivity (σ"), contaminated&lt;br&gt;samples are distinguished from uncontaminated samples by their higher magnitudes. Further, the&lt;br&gt;dissolved phase samples cluster in the intermediate σ", whereas residual phase samples show highest σ".&lt;br&gt;Although σ&apos; results from the unsaturated zone are complicated by variable soil moisture content, σ"&lt;br&gt;shows similar patterns as for the saturated zone. We infer from the strong response exhibited by residual&lt;br&gt;phase samples that biodegradation is most active in this zone. Scanning electron microscope images&lt;br&gt;from the depth interval of residual hydrocarbon phase samples show that this zone had extensive etching&lt;br&gt;and pitting of quartz and feldspar grains. It is possible that etching and pitting results in an increase in&lt;br&gt;the surface area of the mineral grains, producing the strong polarization observed for the residual phase&lt;br&gt;samples. These results suggest that IP is potentially a better indicator of contamination and&lt;br&gt;biodegradation than DC resistivity. However, more laboratory and field investigations are required to&lt;br&gt;better understand the effect of biodegradation processes on the measured SIP response and the surface&lt;br&gt;conduction mechanism.
C(15) configuration of isopimarene-15,16-diols (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTC(15) configuration of isopimarene-15,16-diolsErnest Wenkert, Muppala S. Raju, Paolo Ceccherelli, Massimo Curini, Marco Tingoli, and Roberto PellicciariCite this: J. Org. Chem. 1980, 45, 4, 741–744Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01292a047https://doi.org/10.1021/jo01292a047research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small-particle composites. I. Linear optical properties (1996)

Absorption and extinction spectra of fractal and nonfractal small-particle composites are studied. General solutions of the coupled-dipole equations with the exact operator for the dipole interaction (including the near-, intermediate-, and far-zone terms) are found and compared with those in the quasistatic approximation. Broad-scale numerical simulations of optical spectra for clusters containing a large number of particles (up to 10 000) are performed. A significant fraction of dipolar eigenmodes in fractal aggregates is shown to be strongly localized. The eigenmodes cover a wide spectral region providing resonant enhancement in the visible and infrared parts of the spectrum. In contrast to previous predictions, the absorption spectrum is shown to be significantly different from the spectral distribution of the density of dipole eigenmodes. It clearly indicates the importance of symmetry properties of the modes and corresponding selection rules for the absorption by different modes in random fractal composites. Our experimental data obtained for extinction spectra of silver colloid fractal aggregates are in good agreement with the results of numerical simulations. \textcopyright{} 1996 The American Physical Society.
AN INVERSE FINITE-ELEMENT TECHNIQUE TO DETERMINE THE CHANGE OF PHASE INTERFACE LOCATION IN ONE-DIMENSIONAL MELTING PROBLEMS (1984)

A "front-tracking" finite-element method has been developed for the study of inverse one-dimensional conduction heat transfer problems with phase change. The method can be used to determine the transient position of the change of phase interface and the thermal history in the solid region from information concerning the temperature history at two arbitrary points in the solid region. This technique can be employed in the control and experimental evaluation of practical heat transfer problems with phase change, such as welding. The accuracy of the method is illustrated through numerical experimentation and found to depend on a typical dimensionless Fourier number.
Diverse oligomeric states of CEACAM IgV domains (2015)

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) comprise a large family of cell surface adhesion molecules that bind to themselves and other family members to carry out numerous cellular functions, including proliferation, signaling, differentiation, tumor suppression, and survival. They also play diverse and significant roles in immunity and infection. The formation of CEACAM oligomers is caused predominantly by interactions between their N-terminal IgV domains. Although X-ray crystal structures of CEACAM IgV domain homodimers have been described, how CEACAMs form heterodimers or remain monomers is poorly understood. To address this key aspect of CEACAM function, we determined the crystal structures of IgV domains that form a homodimeric CEACAM6 complex, monomeric CEACAM8, and a heterodimeric CEACAM6-CEACAM8 complex. To confirm and quantify these interactions in solution, we used analytical ultracentrifugation to measure the dimerization constants of CEACAM homodimers and isothermal titration calorimetry to determine the thermodynamic parameters and binding affinities of CEACAM heterodimers. We found the CEACAM6-CEACAM8 heterodimeric state to be substantially favored energetically relative to the CEACAM6 homodimer. Our data provide a molecular basis for the adoption of the diverse oligomeric states known to exist for CEACAMs and suggest ways in which CEACAM6 and CEACAM8 regulate the biological functions of one another, as well as of additional CEACAMs with which they interact, both in cis and in trans.
Bifunctional Abietadiene Synthase:  Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites (2001)

Abietadiene synthase (AS) catalyzes two sequential, mechanistically distinct cyclizations in the conversion of geranylgeranyl diphosphate to a mixture of abietadiene double bond isomers as the initial step of resin acid biosynthesis in grand fir (Abies grandis). The first reaction converts geranylgeranyl diphosphate to the stable bicyclic intermediate (+)-copalyl diphosphate via protonation-initiated cyclization. In the second reaction, diphosphate ester ionization-initiated cyclization generates the tricyclic perhydrophenanthrene-type backbone, and is directly coupled to a 1,2-methyl migration that generates the C13 isopropyl group characteristic of the abietane family of diterpenes. Using the transition-state analogue inhibitor 14,15-dihydro-15-azageranylgeranyl diphosphate, it was demonstrated that each reaction of abietadiene synthase is carried out at a distinct active site. Mutations in two aspartate-rich motifs specifically delete one or the other activity and the location of these motifs suggests that the two active sites reside in separate domains. These mutants effectively complement each other, suggesting that the copalyl diphosphate intermediate diffuses between the two active sites in this monomeric enzyme. Free copalyl diphosphate was detected in steady-state kinetic reactions, thus conclusively demonstrating a free diffusion transfer mechanism. In addition, both mutant enzymes enhance the activity of wild-type abietadiene synthase with geranylgeranyl diphosphate as substrate. The implications of these results for the kinetic mechanism of abietadiene synthase are discussed.