gebhart/patrepeval huggingface dataset:
Materials for polymer electronics applications – semiconducting polymer thin films and nanoparticles (2004)

Abstract The paper presents two different approaches to nanostructured semiconducting polymer materials: (i) the generation of aqueous semiconducting polymer dispersions (semiconducting polymer nanospheres SPNs) and their processing into dense films and layers, and (ii) the synthesis of novel semiconducting polyfluorene‐ block ‐polyaniline (PF‐ b ‐PANI) block copolymers composed of conjugated blocks of different redox potentials which form nanosized morphologies in the solid state.
Drug‐induced Obesity (2001)

Weight gain is a common, but often overlooked side-effect to many widely prescribed drugs. In susceptible individuals, weight gain may result in obesity and associated comorbidities. Tricyclic antidepressants, antipsychotics, lithium, valproate and glucocorticoids are those drugs prominently associated with persistent weight gain affecting more than 50% of the patients depending on dose and duration of exposure. Weight gain is among the most troublesome side-effects reported by the patients and have serious impact on compliance, but is often not recognized since it is seen as improvement of both psychiatric and metabolic diseases. The mechanisms are poorly understood. Increased energy intake due to interference with appetite-regulating neurotransmitters, especially serotonin, has been proposed. Sedative and anticholinergic effects, reduced energy expenditure or increased insulin sensitivity may be important. Treatment is difficult. Regular body weight measurements, selection of the least weight-promoting medication, dietary advice and exercise programs are still the fundamentals for the treatment.
A Low-Power Tunable Frequency Selective Surface for Multiplexed Remote Sensing (2021)

In this interdisciplinary work, a low-power varactor-tunable frequency selective surface is presented for use with a multiplexed remote sensor system. Combined with a low power sensor and control system, voltage biasing of the proposed frequency selective surface panel can be used to modulate the center frequency of a reflection peak, which in turn may be detected by remote interrogation through a radar system. The control board and frequency selective surface were found to draw only <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$200~\mu \text{A}$ </tex-math></inline-formula> of current during typical operation from two 3V CR2032 button batteries, enabling continuous operation for weeks at a time (even longer if operated in wake-up mode) when used in conjunction with a suitably low power sensor. Centered at 3 GHz, the backscatter peak can be modulated across a range of 200 MHz, and the combined system was shown to successfully differentiate between various concentrations of ammonia under test conditions.
Fourier Plane-Wave Series Expansion for Holographic MIMO Communications (2021)

Imagine a MIMO communication system that fully exploits the propagation characteristics offered by an electromagnetic channel and ultimately approaches the limits imposed by wireless communications. This is the concept of Holographic MIMO communications. Accurate and tractable channel modeling is critical to understanding its full potential. Classical stochastic models used by communications theorists are derived under the electromagnetic far-field assumption, i.e. planar wave approximation over the array. However, such assumption breaks down when electromagnetically large (compared to the wavelength) antenna arrays are considered. In this paper, we start from the first principles of wave propagation and provide a Fourier plane-wave series expansion of the channel response, which fully captures the essence of electromagnetic propagation in arbitrary scattering and is also valid in the (radiative) near-field. The expansion is based on the Fourier spectral representation and has an intuitive physical interpretation, as it statistically describes the angular coupling between source and receiver. When discretized uniformly, it leads to a low-rank semi-unitarily equivalent approximation of the electromagnetic channel in the angular domain. The developed channel model is used to compute the ergodic capacity of a point-to-point Holographic MIMO system with different degrees of channel state information.
Prevalence and spectrum of p53 mutations associated with smoking in breast cancer. (2002)

To explore the role of smoking in breast cancer, we undertook a population-based study to evaluate the prevalence and spectrum of p53 mutations in the breast tumors of smokers and nonsmokers. We evaluated 456 archival invasive breast tumors for mutations in exons 4-8 of the p53 gene, using single-strand conformational polymorphism analysis and manual sequencing. Statistical analyses were performed to determine the association of p53 mutations with clinical and smoking characteristics. Of 108 mutations identified, 77 (71%) were point mutations and 31 (29%) were deletions or insertions. A higher prevalence of p53 mutations was found in the breast tumors of current smokers (36.5%; P = 0.02) compared with never smokers (23.6%), whereas fewer mutations were found in former smokers (16.2%; P = 0.09). After adjustment for age, race, menopausal status, clinical stage, tumor size, and family history of breast cancer, current smokers were significantly more likely to harbor any p53 mutation [odds ratio (OR), 2.11; 95% confidence interval (CI), 1.17-3.78], p53 transversions (OR, 3.37; 95% CI, 1.03-11.06), and G:C-->T:A transversions (OR, 10.53; 95% CI, 1.77-62.55) compared with never smokers. Stage at diagnosis did not account for the increase in p53 mutation-positive breast cancer among current smokers. Former smokers were also more likely than never smokers to harbor G:C-->T:A transversions (OR, 2.43; 95% CI, 0.37-15.73), although this association was not statistically significant. Among former smokers, the prevalence of p53 mutations varied with time since quitting: former smokers who quit smoking for longer than 1 year had a lower prevalence of p53 mutations (10.5% for 1-5 years and 12.9% for >5 years) than those who had stopped smoking within the year of their cancer diagnosis (26.3%). Our results indicate that cigarette smoking appears to modify the prevalence and spectrum of p53 mutations in breast tumors. Moreover, the difference in mutational spectra observed between smokers and nonsmokers is suggestive of the genotoxic effects of smoking in breast tissue.
Defective Mitochondrial Biogenesis (2007)

The metabolic syndrome is a group of risk factors of metabolic origin that are accompanied by increased risk for type 2 diabetes mellitus and cardiovascular disease. These risk factors include atherogenic dyslipidemia, elevated blood pressure and plasma glucose, and a prothrombotic and proinflammatory state. The condition is progressive and is exacerbated by physical inactivity, advancing age, hormonal imbalance, and genetic predisposition. The metabolic syndrome is a particularly challenging clinical condition because its complex molecular basis is still largely undefined. Impaired cell metabolism has, however, been suggested as a relevant pathophysiological process underlying several clinical features of the syndrome. In particular, defective oxidative metabolism seems to be involved in visceral fat gain and in the development of insulin resistance in skeletal muscle. This suggests that mitochondrial function may be impaired in the metabolic syndrome and, thus, in the consequent cardiovascular disease. We have recently found that mitochondrial biogenesis and function are enhanced by nitric oxide in various cell types and tissues, including cardiac muscle. Increasing evidence suggests that this mediator acts as a metabolic sensor in cardiomyocytes. This implies that a defective production of nitric oxide might be linked to dysfunction of the cardiomyocyte metabolism. Here we summarize some recent findings and propose a hypothesis for the high cardiovascular risk linked to the metabolic syndrome.
Field demonstration of mode-division multiplexing upgrade scenarios on commercial networks (2013)

We demonstrate three possible scenarios for upgrading current single-mode transmission networks with high capacity few-mode fiber technology using mode-division multiplexing (MDM). The results were obtained from measurements over a number of field-deployed single-mode fiber links with an additional experimental in-line amplified few-mode fiber link. The results confirm the viability of employing MDM using few-mode fiber technology to gradually replace legacy optical systems.
Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T cell lymphoma (2010)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To compare the efficacy of allogeneic stem cell transplantation and conventional therapy in the treatment of advanced primary cutaneous T cell lymphoma.
Mapping blood biochemistry by Raman spectroscopy at the cellular level (2021)

We report how Raman difference imaging provides insight on cellular biochemistry <i>in vivo</i> as a function of sub-cellular dimensions and the cellular environment. We show that this approach offers a sensitive diagnostic to address blood biochemistry at the cellular level. We examine Raman microscopic images of the distribution of the different hemoglobins in both healthy (discocyte) and unhealthy (echinocyte) blood cells and interpret these images using pre-calculated, accurate pre-resonant Raman tensors for scattering intensities specific to hemoglobins. These tensors are developed from theoretical calculations of models of the oxy, deoxy and met forms of heme benchmarked against the experimental visible spectra of the corresponding hemoglobins. The calculations also enable assignments of the electronic transitions responsible for the colour of blood: these are mainly ligand to metal charge transfer transitions.
Manganese-enriched electrochemistry of LiFePO4/RGO nanohybrid for aqueous energy storage (2017)

Manganese-doped lithium iron phosphate (LFMP) integrated with reduced graphene oxide (RGO) has been prepared via microwave-assisted synthesis and investigated as lithium-ion energy storage system in aqueous Li2SO4 electrolyte. The doping of the LFP was achieved with a low-cost commercial electrolytic manganese oxide (EMD) precursor using a microwave-assisted solvothermal technique. When compared to the undoped counterpart (LFP/RGO), obtained under similar experimental conditions, the LFMP/RGO nanohybrid showed an improved electrochemical performance. The LFMP/RGO gave a maximum areal capacitance of ca. 39.48 mF cm−2, power density of 70.3 mW cm−2 and energy density of 8 mWh cm−2 compared to the values for the pristine complex (LFP/RGO); ca. 16.85 mF cm−2, 54.4 mW cm−2 and 4.8 mWh cm−2. In addition, when the two types of electrochemical storage systems were subjected to voltage-holding (floating) experiment for 50 h, LFMP/RGO maintained 98% capacitance retention while LFP/G maintained 94% capacitance retention. The findings in this work prove that Mn-doping is capable of enhancing the electrochemical performance of the LFP material for energy storage.
A 1.2V 121-Mode CT &#x00394;&#x003A3; Modulator for Wireless Receivers in 90nm CMOS (2007)

A reconfigurable CT 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -order 1b ΔΣ modulator is presented. The DR/BW is programmable from 85dB@100kHz to 52dB@10MHz in 121 steps. Implemented in a 90nm CMOS process, the 0.36mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> IC includes 2 ΔΣ modulators, a bandgap reference, and a decimator. The power consumption of a single ADC in different modes ranges from 1.44 to 7mW at 1.2V supply
A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint (2006)

The spindle assembly checkpoint guards the fidelity of chromosome segregation. It requires the close cooperation of cell cycle regulatory proteins and cytoskeletal elements to sense spindle integrity. The role of the centrosome, the organizing center of the microtubule cytoskeleton, in the spindle checkpoint is unclear. We found that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex (gamma-TuRC). However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation.
Palladium Complexes of Methylene-Bridged P-Stereogenic, Unsymmetrical Diphosphines (2020)

Optically pure P-stereogenic methylphosphine–boranes P(BH3)PhArMe (Ar = 1-naphthyl (1-Np), 9-phenanthryl (1-Phen), 2-biphenylyl (1-Biph)) have been used to prepare six diphosphines of the type PPhAr–CH2–PR2 (R = Ph or i-Pr; 3-ArR) with a methylene bridge between the phosphorus atoms and a single P-stereogenic moiety. The ligands have been reacted with [PdCl2(COD)] to furnish the corresponding [PdCl2(P–P′)] complexes. The reaction with [PdCl(η3-2-methylallyl)]2 and NH4PF6 has produced the expected [Pd(η3-2-methylallyl)(P–P′)]PF6 complexes as stable species in solution only for the ligands containing the diisopropylphosphino group. The other ligands produced a mixture of species in solution, from which the dimeric complex [Pd2(η3-2-methylallyl)2(PNpPh-CH2-PPh2)2](PF6)2, and the coordination compound [Pd(PBiphPh-CH2-PPh2)2](PF6)2 could be crystallographically characterized.
ChemInform Abstract: Solid Supported Reactions. Part 4. The Reduction of Aromatic Oximes to Amines with Borohydride Exchange Resin‐Nickel Acetate System. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recherche de la mutation du gène CDKN1B dans les adénomes hypophysaires familiaux isolés (FIPA): analyse de 86 familles (2010)

peer reviewed
Indolin-2-ones with High in Vivo Efficacy in a Model for Multiple Sclerosis (2005)

The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. Activity following po administration was obtained with several analogues and via the use of prodrugs.
Culture, Immortalization, and Characterization of Human Meibomian Gland Epithelial Cells (2010)

The results show that human meibomian gland epithelial cells may be isolated, cultured, and immortalized.
Dynamic Extension of a Virtualized Cluster by using Cloud Resources (2012)

The specific requirements concerning the software environment within the HEP community constrain the choice of resource providers for the outsourcing of computing infrastructure. The use of virtualization in HPC clusters and in the context of cloud resources is therefore a subject of recent developments in scientific computing. The dynamic virtualization of worker nodes in common batch systems provided by ViBatch serves each user with a dynamically virtualized subset of worker nodes on a local cluster. Now it can be transparently extended by the use of common open source cloud interfaces like OpenNebula or Eucalyptus, launching a subset of the virtual worker nodes within the cloud. This paper demonstrates how a dynamically virtualized computing cluster is combined with cloud resources by attaching remotely started virtual worker nodes to the local batch system.
Receptors for neuropeptides are induced by exogenous poly(A)+ RNA in oocytes from Xenopus laevis. (1988)

Receptors for the hormones vasopressin, angiotensin II, and thyrotropin-releasing hormone have been studied electrophysiologically in Xenopus laevis oocytes previously injected with poly(A)+ RNA from the respective receptor-containing tissues. The injected oocytes responded to the hormones by demonstrating oscillations in membrane currents as recorded by the voltage-clamp method. The response was dependent on the hormone concentrations and detectable between 5 and 1000 nM concentrations. Size fractionation of poly(A)+ RNA from the respective tissues showed that the mRNAs encoding the three hormone receptors were larger than 18S rRNA, suggesting a length of at least 2 kilobases. When vasopressin was added to the oocyte bath, an inward membrane current was generated in oocytes injected with rat poly(A)+ RNA from liver but not from kidney. This suggests that the V1-type (liver), not the V2-type (kidney), vasopressin receptor can be expressed and electrophysiologically identified in the oocyte. A V1-specific, but not a V2-specific, antagonist suppressed the vasopressin-dependent effect. Application of angiotensin II to liver poly(A)+ RNA-injected oocytes elicited oscillations in membrane current, indicating that these oocytes also expressed receptors for angiotension II; the antagonist [Sar1, O-methionyl-Tyr4]angiotensin II blocked this effect. Poly(A)+ RNA from tumor-derived GH3B6 cells, known to contain receptors for thyrotropin-releasing hormone, injected into oocytes induced receptors responding to thyrotropin-releasing hormone; the drug chlordiazepoxide suppressed the thyrotropin-releasing hormone response.
Computational analysis of surface‐tension‐driven coating‐defect flow (2001)

Abstract Bondline readout (BLRO) is a coating defect frequently exhibited on adhesively‐bonded, polymeric automotive body panels painted with high‐glamor/flow clearcoats. BLRO or telegraphing results from Marangoni‐type, surface‐tension‐driven flows. An efficient numerical code was developed to predict temperature‐ and concentration‐induced BLRO flows to use it as an effective tool for screening and developing potential clearcoat systems. Two numerical codes were developed: a 1‐D code based on the lubrication approximation; a 2‐D code based on the SIMPLER (Semiimplicit method for pressure‐linked equations revised) algorithm. The 1‐D code produced BLRO profiles in agreement with those predicted from the 2‐D code and those measured from BLRO flow experiments, thus confirming a proposed BLRO mechanism. Moreover, the 1‐D code was vastly more time‐efficient than the 2‐D code due to a severe time‐step stability limitation found with the latter.
Graphene oxide–metal nanocomposites for cancer biomarker detection (2017)

We report a universal protocol for the <italic>in situ</italic> bioinspired green synthesis of metal nanoparticles on simultaneously reduced graphene oxide sheets using a black pepper extract for quantification of breast cancer biomarker.
Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and mitochondrial complex II + III during the development of right ventricular hypertrophy in the neonatal pig heart (2011)

Persistent pulmonary hypertension of the newborn (PPHN) results in right ventricular (RV) hypertrophy followed by right heart failure and an associated mitochondrial dysfunction. The phospholipid cardiolipin plays a key role in maintaining mitochondrial respiratory and cardiac function via modulation of the activities of enzymes involved in oxidative phosphorylation. In this study, changes in cardiolipin and cardiolipin metabolism were investigated during the development of right heart failure. Newborn piglets (<24 h old) were exposed to a hypoxic (10% O(2)) environment for 3 days, resulting in the induction of PPHN. Two sets of control piglets were used: 1) newborn or 2) exposed to a normoxic (21% O(2)) environment for 3 days. Cardiolipin biosynthetic and remodeling enzymes, mitochondrial complex II + III activity, incorporation of [1-(14)C]linoleoyl-CoA into cardiolipin precursors, and the tetralinoleoyl-cardiolipin pool size were determined in both the RV and left ventricle (LV). PPHN resulted in an increased heart-to-body weight ratio, RV-to-LV plus septum weight ratio, and expression of brain naturetic peptide in RV. In addition, PPHN reduced cardiolipin biosynthesis and remodeling in the RV and LV, which resulted in decreased tetralinoleoyl-cardiolipin levels and reduced complex II + III activity and protein levels of mitochondrial complexes II, III, and IV in the RV. This is the first study to examine the pattern of cardiolipin metabolism during the early development of both the RV and LV of the newborn piglet and to demonstrate that PPHN-induced alterations in cardiolipin biosynthetic and remodeling enzymes contribute to reduced tetralinoleoyl-cardiolipin and mitochondrial respiratory chain function during the development of RV hypertrophy. These defects in cardiolipin may play an important role in the rapid development of RV dysfunction and right heart failure in PPHN.
Debridement Arthroplasty for Osteoarthritis of the Elbow (1998)

For treatment of osteoarthritis of the elbow, the authors use debridement arthroplasty with a medial or lateral approach. Thirty-eight elbows in 36 patients treated with this procedure were examined. The age of the patients ranged from 20 to 71 years, with a mean age of 41.7 years. Cubital tunnel syndrome was present in 16 of the 38 (42%) elbows. The operations were performed through a lateral approach in four elbows, a lateral approach with medial skin incision for ulnar nerve neurolysis in 16 elbows, a medial approach in 10 elbows, and a medial plus a lateral approach in eight elbows. The followup ranged from 2 years to 12.1 years, with an average of 5.9 years. Complete pain relief or minimal elbow pain was reported in 95% of patients who had surgical treatment. The average gain in motion was 6 degrees extension and 18 degrees flexion. Results for the various surgical approaches did not show a statistically significant difference. Recurrence of bony spurs and ridges was analyzed additionally in 18 selected patients who could be observed more than 5 years after surgery (range, 5-12 years). Redevelopment of bony spurs on the coronoid process and olecranon tip occurred in all 18 patients, but those changes were graded as mild in 13 (74%) patients and moderate in five (16%) patients and were accompanied by no pain or slight pain. Elbow arthroplasty as used by the authors produces stable and reliable results for relief of pain, gains in range of motion, and the absence of recurrence of significant osteoarthritis.
<title>Sum frequency vibrational spectroscopy of the solid-liquid interface</title> (1995)

Sum-frequency spectroscopy (SFS) has been used to elucidate the structure of surfactant monolayers at the hydrophobic solid-water interface. The polar orientation and conformational order of a series of surfactant molecules has been determined from the vibrational spectra of their hydrocarbon chains in the C-H stretching region. The SF spectra of inorganic (thiocyanate and cyanide) and aromatic (tosylate, benzoate, and salicylate) counterions indicate that they bind to a monolayer of charged surfactant with a net polar orientation. The spectra of the aromatic anions bound to a surfactant monolayer at the air-water interface are also presented. The interactions between co-adsorbed surfactant and polymer has been examined-- the spectra of the surfactant indicate that an oppositely charged polymer causes a monolayer of the surfactant to adsorb at much lower bulk concentrations than in the absence of the polymer. In one case, the bound polymer has a SF-active resonance indicating that the polymer is also orientationally ordered at the solid-water interface.