gebhart/patrepeval huggingface dataset:
Shifts in gamma phase–amplitude coupling frequency from theta to alpha over posterior cortex during visual tasks (2010)

The phase of ongoing theta (4-8 Hz) and alpha (8-12 Hz) electrophysiological oscillations is coupled to high gamma (80-150 Hz) amplitude, which suggests that low-frequency oscillations modulate local cortical activity. While this phase-amplitude coupling (PAC) has been demonstrated in a variety of tasks and cortical regions, it has not been shown whether task demands differentially affect the regional distribution of the preferred low-frequency coupling to high gamma. To address this issue we investigated multiple-rhythm theta/alpha to high gamma PAC in two subjects with implanted subdural electrocorticographic grids. We show that high gamma amplitude couples to the theta and alpha troughs and demonstrate that, during visual tasks, alpha/high gamma coupling preferentially increases in visual cortical regions. These results suggest that low-frequency phase to high-frequency amplitude coupling is modulated by behavioral task and may reflect a mechanism for selection between communicating neuronal networks.
Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin–dopamine activity modulator (2015)

Cognitive impairment, including impaired social cognition, is largely responsible for the deterioration in social life suffered by patients with psychiatric disorders, such as schizophrenia and major depressive disorder (MDD). Brexpiprazole (7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one), a novel serotonin-dopamine activity modulator, was developed to offer efficacious and tolerable therapy for different psychiatric disorders, including schizophrenia and adjunctive treatment of MDD. In this study, we investigated whether brexpiprazole could improve social recognition deficits (one of social cognition deficits) in mice, after administration of the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine). Dosing with dizocilpine (0.1mg/kg) induced significant impairment of social recognition in mice. Brexpiprazole (0.01, 0.03, 0.1mg/kg, p.o.) significantly ameliorated dizocilpine-induced social recognition deficits, without sedation or a reduction of exploratory behavior. In addition, brexpiprazole alone had no effect on social recognition in untreated control mice. By contrast, neither risperidone (0.03mg/kg, p.o.) nor olanzapine (0.03mg/kg, p.o.) altered dizocilpine-induced social recognition deficits. Finally, the effect of brexpiprazole on dizocilpine-induced social recognition deficits was antagonized by WAY-100,635, a selective serotonin 5-HT1A antagonist. These results suggest that brexpiprazole could improve dizocilpine-induced social recognition deficits via 5-HT1A receptor activation in mice. Therefore, brexpiprazole may confer a beneficial effect on social cognition deficits in patients with psychiatric disorders.
Plantar-to-Dorsal Compared to Dorsal-to-Plantar Screw Fixation for Proximal Chevron Osteotomy: A Biomechanical Analysis (2005)

Plantar-to-dorsal screw orientation was more stable than the conventional dorsal-to-plantar screw orientation for fixation of the proximal chevron osteotomy. Plantar-to-dorsal screw orientation should be considered when using the chevron proximal first metatarsal osteotomy.
Methylation of hepatitis B virus DNA and liver-specific suppression of RNA production in transgenic mouse. (1987)

Three lines of transgenic mice carrying hepatitis B virus (HBV) DNA were produced. In a pSHB1BB transgenic mouse carrying one copy of BamHI fragment of HBV with a deletion of Bg/II-Bg/II fragment, no RNA transcription was observed. Transgenic mice that had integrated either one or three tandem copies of HBV DNA produced RNA in various tissues except liver. However, neither initiation nor termination of transcription occurred at the correct place. Hepatitis B surface antigen and hepatitis B e antigen were not detectable in these transgenic mice. HBV DNA was methylated at all CCGG sequences, which might have resulted in aberrant RNA production. In two out of five transgenic mice HBV DNA was integrated into the Y chromosome. Although the frequency is unusually high, the mechanism is not known yet.
Analysis of the functional dependability of underground gas storage compressor stations in cases when actual performance indicators deviate from the design values (2022)

Aim. The paper examined the matter of assessment of the functional dependability of compressor stations (CS) of underground gas storage (UGS) facilities. A definition of CS functional dependability and guidelines for its assessment were proposed. Methods. Design calculation of compressor stations, scenario analysis. Results. The paper presents: a) a definition, indicators of CS functional dependability and guidelines for its assessment; b) an example of the guidelines application for UGS CS; c) a comparative analysis of UGS CS functional dependability in a number of various versions: use of single-unit and two-unit centrifugal compressors as part of gas turbine gas pumping units for two-stage compression with intercooling. Conclusion. The paper shows the requirement to analyse the functional dependability of various versions of UGS CS for the purpose of identifying the most rational option that ensures unconditional performance of the key UGS CS function under uncertain initial design data.
Heat Shock Protein 60, via MyD88 Innate Signaling, Protects B Cells from Apoptosis, Spontaneous and Induced (2009)

We recently reported that heat shock protein 60 (HSP60) via TLR4 signaling activates B cells and induces them to proliferate and secrete IL-10. We now report that HSP60 inhibits mouse B cell apoptosis, spontaneous or induced by dexamethasone or anti-IgM activation. Unlike HSP60 enhancement of B cell proliferation and IL-10 secretion, TLR4 signaling was not required for the inhibition of apoptosis by HSP60; nevertheless, MyD88 was essential. Inhibition of apoptosis by HSP60 was associated with up-regulation of the antiapoptotic molecules Bcl-2, Bcl-x(L), and survivin, maintenance of the mitochondrial transmembrane potential, and inhibition of caspase-3 activation. Moreover, B cells incubated with HSP60 manifested prolonged survival following transfer into recipient mice. These results extend the varied role of HSP60 in the innate regulation of the adaptive immune response.
Direct Inhibitory Effect of Gonadotropin-Releasing Hormone upon Luteal Luteinizing Hormone Receptor and Steroidogenesis in Hypophysectomized Rats* (1980)

The effects of gonadotropin-releasing hormone (GnRH) and its potent agonist [des-Gly10, D-Leu6-N alpha Me) Leu7, Pro9,NHEt-GnRH (GnRH-A)] on ovarian luteal functions maintained by PRL were studied in vivo and in vitro. Hypophysectomized, diethylstilbestrol-treated female rats were primed with FSH for 2 days, followed by an ovulating dose of LH or hCG. Two days later, ovarian luteal functions were maintained by daily injections of 250 microgram PRL for 3 days. PRL treatment increased the serum progesterone level from 13.0 +/- 0.5 to 298 +/- 24 ng/ml and increased the ovarian hCG-binding capacity from 5.8 +/- 1.3 to 584 +/- 86 ng bound hCG/ovary. In contrast, concomitant treatment with GnRH or GnRH-A resulted in dose-dependent decreases in the PRL-induced increase of serum progesterone and ovarian LH/hCG receptor content. GnRH at 100 microgram/day caused a 60% decrease in serum progesterone and an 80% decrease in ovarian LH receptor content, whereas GnRH-A was effective at a 1-microgram dose level. Neither GnRH nor GnRH-A affected the binding affinity (Kd) of ovarian LH receptor. The direct inhibitory effects of GnRH and GnRH-A upon granulosa-luteal cell function were also tested in vitro. FSH treatment for 2 days induced functional LH and PRL receptors in cultured PRL, increased (by approximately 3-fold) progesterone production by these granulosa-luteal cells, whereas concomitant treatment with GnRH-A inhibited progesterone production in a dose-dependent manner. Thus, these studes demonstrated that GnRH and GnRH-A exert direct inhibition on ovarian luteal functions by decreasing LH receptor and progesterone production in vivo as well as inhibiting progesterone production by cultured granulosa-luteal cells in vitro.
Tactile taps teach rhythmic text entry (2016)

Passive Haptic Learning (PHL) is the acquisition of sensorimotor skills with little or no active attention to learning. This technique is facilitated by wearable computing, and applications are diverse. However, it is not known whether rhythm-based information can be conveyed passively. In a 12 participant study, we investigate whether Morse code, a rhythmbased text entry system, can be learned through PHL using the bone conduction transducer on Google Glass. After four hours of exposure to passive stimuli while focusing their attention on a distraction task, PHL participants achieved a 94% accuracy rate keying a pangram (a phrase with all the letters of the alphabet) using Morse code on Glass's trackpad versus 53% for the control group. Most PHL participants achieved 100% accuracy before the end of the study. In written tests, PHL participants could write the codes for each letter of the alphabet with 98% accuracy versus 59% for control. When perceiving Morse code, PHL participants also performed significantly better than control: 83% versus 46% accuracy.
Definition of tumor-associated antigens in hepatocellular carcinoma. (2000)

With an estimated annual incidence of about one million cases, hepatocellular carcinoma (HCC) is one of the most common neoplasms worldwide. Of all malignant diseases, it is the major cause of death in some regions of Africa and Asia. The pathogenic mechanisms responsible for HCC are not well defined, and therapeutic means, especially in inoperable HCCs, are still unsatisfactory and await improvement. In the quest for tumor antigens exploitable for gene therapy, we studied immune responses in the context of HCC. A cDNA library derived from a human HCC sample was screened using the SEREX approach. Nineteen distinct antigens reactive with autologous IgG were identified. Sequence analysis revealed three of the cDNA clones to code for hitherto unknown proteins and 16 known genes products. Proteins as diverse in function as LDH, albumin, and kinectin were found. Furthermore, proteins involved in the transcription/translation machinery had elicited an immune response in the autologous host. A panel of allogenic sera including sera from patients with hepatitis, liver cirrhosis, HCC, and other tumor entities, as well as sera from normal individuals, was used for frequency analysis of antibody responses. Whereas allogenic sera of HCC patients detected most antigens at a high percentage, control sera were rarely antibody-positive. The nature of the major fraction of antigens described here are linked to liver. Thus, our findings demonstrate not only the complexity of the humoral immune response against HCC, but may also offer new insight into mechanisms underlying transformation of the liver cell.
Restoration of tumor suppression in vivo by systemic delivery of chemically-modified PTEN mRNA nanoparticles. (2017)

11582 Background: The onset and maintenance of cancer frequently involves gain of oncogenic function along with loss of tumor suppression. PTEN is a well-characterized tumor suppressor gene that is lost or mutated in many human cancers including ~50% of metastatic castration-resistant prostate cancer (mCRPC). Reintroduction of functional PTEN for mCRPC treatment has proven difficult. Methods: PTEN mRNA was synthesized by in vitro transcription method and modified with ARCA capping and enzymatic polyadenylation, and then substituted with Pseudo-UTP, 5’-Methyl-CTP. A robust self-assembly approach was employed to prepare PTEN mRNA nanoparticles (NPs) using cationic lipid-like compound G0-C14 and PLGA polymer coated with lipid-PEG shell. PTEN expression in tumors and PI3K-AKT pathway were confirmed by IHC and western blot, respectively. Apoptosis was checked by flow cytometry and Tunel assays. In vivo toxicity was studied by hematologic and histologic tests, and immune response. Results: We successfully restored PTEN mRNA to PTEN-null prostate cancer (PCa) cells via systemic delivery of mRNA NPs. These mRNA NPs are stable in serum, demonstrate minimal toxicity, and provide highly effective transfection in PCa cells (substantially higher HA-PTEN expression than plasmid PTEN transfection) and PCa xenograft tumors, leading to ~85% inhibition of tumor cell growth in vitro and in vivo. We also confirm mRNA NP-mediated systemic restoration of PTEN function in PTEN-null PCa and delineate its tumor suppression through inhibition of the PI3K-AKT pathway and enhancement of apoptosis. Conclusions: The work provides proof of principle for the systemic reintroduction of mRNA-based tumor suppressor genes to tumors in vivo. Because PTEN loss is frequent in late-stage PCa, this approach may have feasibility in this patient population. Considering the strong potential of mRNA therapy and the lack of systemic studies of in vivo mRNA transfection of tumors, this study sheds light on the useful application of NP-mediated mRNA delivery for validating tumor suppressors (e.g., PTEN) as a therapeutic target in cancer treatment where loss of a tumor suppressor contributes to the underlying genetic mechanism of cancer.
Numerical Analysis of the Vaned Diffuser of a Transonic Centrifugal Compressor (2010)

A three-dimensional Navier–Stokes solver is used to investigate the flow field of a high pressure ratio centrifugal compressor for turbocharger applications. Such a compressor consists of a double-splitter impeller followed by a vaned diffuser. Particular attention is focused on the analysis of the vaned diffuser, designed for high subsonic inlet conditions. The diffuser is characterized by a complex three-dimensional flow field and influenced by the unsteady interaction with the impeller. Detailed particle image velocimetry flow measurements within the diffuser are available for comparison purposes.
[Experimental study of the sensitizing properties of halothane]. (1976)

The sensitizing properties of halothane were investigated experimentally in guinea pigs using two different techniques. The first method, derived from that of DRAIZE, included a sensitizing phase in which the product was administered by inhalation, while the second method, derived from that of MAGNUSSON and KLIGMAN, used guinea pigs sensitized to FREUND's adjuvant and which were sensitized to halothane administered subcutaneously. The results obtained in these two series of experiments appeared concordant. They showed that effective sensitization occurred in 60 to 80 p. 100 of the animals treated. This places halothane between level 3 (moderate potency) and level 4 (high potency) on the classical drug scale of "allergenic potencies".
Final Elucidation of the Absolute Configuration of the Signal Metabolite Hormaomycin (2004)

The complete absolute configuration of hormaomycin 1 a has been established by HPLC and HPLC/MS experiments with appropriately derivatized 4-propylprolines, (2S,4S)-6 and (2R,4R)-6, as well as 4-(Z)-propenylprolines, cis-5 and trans-5, and also feeding experiments with enantiomerically pure samples of the deuterium-labeled 3-(2'-nitrocyclopropyl)alanine, (2S)-3,3-[D2]15 and (2S)-2,2'-[D2]15, and 4-(Z)-propenylproline 2',4-[D2]-(2S,4R)-5. The latter five amino acids were prepared for the first time and allowed one to unequivocally assign the hitherto unknown absolute configurations of the last four stereocenters in hormaomycin 1 a. As a bonus, some new information about the biosynthesis of this molecule has also been gathered.
Figure S9 from AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia (2023)

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Dose-escalation results of a phase I study of 225Ac-J591 for progressive metastatic castration resistant prostate cancer (mCRPC). (2020)

114 Background: Prostate-specific membrane antigen (PSMA) can be targeted by antibodies (Ab) or small molecule ligands labeled with potent α emitters (e.g. 225 Ac). Unlike ligands, Ab biodistribution does not include non-tumor organs such as the salivary glands, kidneys and small bowel. We performed a phase I single ascending dose Ab study. Methods: Eligibility: progressive mCRPC following at least 1 potent AR pathway inhibitor (ARPI; e.g. abi/enza) and docetaxel (or unfit/refuse chemo) without limit of # prior therapies provided adequate organ function. Baseline 68 Ga-PSMA11 PET was performed but not used for eligibility. Single-subject cohorts received a single infusion of 225 Ac-J591 until grade (Gr) &gt; 1 attributable toxicity or dose level 5, then transition to 3+3 design. Cohort 1 = 13.3 KBq/kg with planned escalation up to dose level 7 (93.3 KBq/kg). Dose-limiting toxicity (DLT) defined as attributable Gr 4 heme or Gr 3/4 non-heme toxicity. Results: 22 men were treated on 7 dose levels; median age 72.5 (range 58-89), PSA 146.5 (4.8-7168.4); 82% with &gt;2 prior ARPI, 64% chemo, 45% sipuleucel-T, 23% radium-223, 55% prior 177 Lu-PSMA. By standard imaging 82% bone, 36% lymph node, 9% liver mets. At the time of data cutoff, 1 of 6 men in cohort 6 (80 KBq/kg) had DLT (Gr 4 anemia and platelets); he had 4 prior cycles of 177 Lu-PSMA. No other attributable Gr &gt;2 non-hematologic or Gr &gt;3 heme AE (including 0 of 6 at the highest dose level). Low Gr temporary AE’s include: 16 (73%) with fatigue, 11 (50%) pain, 11 (50%) nausea, 6 (27%) with xerostomia (5 of 6 with prior 177 Lu-PSMA), 3 (14%) AST elevation. With follow-up ongoing, 60% with any PSA decline, 35% with &gt;50% PSA decline. Of 10 with detectable baseline and 12-week CTC counts (CellSearch), 8 declined (45-100% decline); 5 (50%) with CTC count conversion. While PSMA uptake was not a prerequisite for treatment, all had some PSMA uptake on 68 Ga-PSMA11 PET/CT; 64% with SUV max &gt;5x liver SUV, 14% 2.5x – 5x liver, and 23% with SUV max 0-2.5x liver SUV. Conclusions: PSMA-targeted alpha-emitter 225 Ac utilizing intact Ab J591 is well tolerated with early evidence of clinical activity in a pre-treated population, including the majority with prior 177 Lu-PSMA. Clinical trial information: NCT03276572.
Effect of hydrocarbon molecular ion size for amorphous region formation analyzed by X-ray photoelectron spectroscopy (2020)

Abstract We investigate the amorphous formation behavior on hydrocarbon molecular ion implantation conditions such as hydrocarbon molecular ion size by X-ray photoelectron spectroscopy (XPS). The cross-sectional radius of the amorphous region was obtained from the peak intensity of the amorphous component in Si 2p spectra analyzed by XPS, and using columnar formula for a model. We confirmed that the cross-sectional radius of the amorphous region formed by hydrocarbon molecular ions differs greatly from that formed by monomer carbon ions, and increases by 0.078 nm as the number of carbon atoms composing the hydrocarbon molecular ion increases. The dependence of amorphous formation on the hydrocarbon molecular size is related to the C–C binding distance, and the ratio of increase in the amorphous cross-sectional radius corresponds to half of the C–C binding distance. Therefore, the collision behavior of hydrocarbon molecular ions during implantation predominantly influence the size of hydrocarbon molecular ions.
IPv6 Neighbor Discovery Unicast Lookup (2019)

This document updates RFC 8505 in order to enable unicast address
lookup from a 6LoWPAN Border Router acting as an Address Registrar.
Advanced Magnetic Nanostructure Characterization via Resonant Soft X-Ray Spectro Holography Imaging in Combination with Microscopic Hysteresis Loop Analysis (2006)

In this article the coherence and tunable polarization of soft X-ray synchrotron radiation for imaging magnetic nanostructures via Fourier Transform Holography is discussed. This new lens-less imaging technique is based on the direct Fourier inversion of a holographically formed soft X-ray interference pattern. This is based on placing the sample behind a lithographically manufactured mask with a micron-sized sample aperture and a nano-sized reference hole. By exploiting the magnetic dichroism in resonance at the L3 edges of the magnetic transition metals (wavelength ~ 1-2 nm (700-900 eV)), images of magnetic nanostructures have been obtained with a spatial resolution of 50 nm. The technique is transferable to a wide variety of specimen, appears scalable to diffraction-limited resolution (about 2 nm), and is well suited for ultra-fast single-shot imaging with future X-ray free electron laser sources.
INTELLECT: a system for authoring, distributing, and presenting multimedia contents over the Internet (2003)

INTELLECT is a full-feature platform for multimedia content development and deployment for diverse application areas, ranging from education and training to electronic commerce and remote consultation. It contains both a client-server multimedia distribution system as well as an authoring tool. INTELLECT is compatible with Web technology, with added capabilities such as multimedia streaming, synchronized multimedia presentation, scalable reliability, and adaptability to network-traffic conditions.
Supplementary Figure 3 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer (2023)

Supplementary Figure 3 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer
Mixing buffers and pass transistors in FPGA routing architectures (2001)

The routing architecture of an FPGA consists of the length of the wires, the type of switch used to connect wires (buffered, unbuffered, fast or slow) and the topology of the interconnection of the switches and wires. FPGA routing architecture has a major influence on the logic density and speed of FPGA devices. Previ?ous work [] based on a 0.35um CMOS process has suggested that an architecture consisting of length 4 wires (where the length of a wire is measured in terms of the number of logic blocks it passes before being switched) and half of the programmable switches are active buffers, and half are pass transistors. In that work, however, the topology of the routing architecture prevented buffered tracks from connecting to pass-transistor tracks. This restriction prevents the creation of interconnection trees for high fanout nets that have a mixture of buffers and pass transistors. Electrical simulations sug?gest that connections closer to the leaves on interconnection trees are faster using pass transistors, but it is essential to buffer closer to the source. This latter effect is well known in regular ASIC routing [2].
Perception of information to Swedish melanoma patients in routine clinical practice – a cross-sectional survey (2022)

Patients lack sufficient information and age affects the perception of it. It is of utmost importance to tailor the information to suit the individual needs of a given patient, as satisfaction with the information received correlates with the patient's well-being.