gebhart/patrepeval huggingface dataset:
Evidence that Alpha-1-Adrenergic Stimuli Specifically Increase Gluconeogenesis of the Isolated Proximal Convoluted Tubule in the Rat (1986)

Isolated kidney-cortical tubule suspensions and microdissected nephron segments from fed rats were used to study the action of catecholamines on gluconeogenesis. Gluconeogenesis from rat tubule suspension incubated with 5 mM pyruvate was stimulated maximally by 10(-5) M methoxamine, an alpha 1-selective agonist, and 10(-6) M noradrenaline by 29.2 +/- 5.2% (mean +/- SEM) and 32.6 +/- 2.9%, respectively. These effects were completely inhibited by 10(-7) M prazosin, a beta 1-selective antagonist. Yohimbine, an alpha 2-antagonist, also inhibited the effect, but only at a higher concentration (5 X 10(-5) M). Gluconeogenesis was not stimulated by isoproterenol, a alpha-agonist, at any concentrations between 10(-5) and 10(-7) M. With microdissected nephron segments, only the proximal tubule possessed gluconeogenic activity. Within the proximal tubule, the proximal convoluted tubule (PCT) revealed higher gluconeogenic activity than the proximal straight tubule (PST). Methoxamine at 10(-5) M stimulated gluconeogenesis in PCT, whereas in PST no increase of gluconeogenesis was observed. From these results, it can be concluded that an alpha 1-adrenergic agonist specifically stimulates renal gluconeogenesis in PCT, but not in PST.
Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome (2005)

Rapid evolution of drug-resistant viruses renders essentially all small-molecule antiviral treatments ineffective. We demonstrate an in vitro library versus library approach to identify small molecules targeting a broad spectrum of HIV-1 Nef protein variants. The technique could provide more effective antiviral therapies. First, a library of clinically derived Nef allelic variants, termed an allelome, was selected for function by binding to Nef ligands p53, actin, or p56lck. Next, a library of small-molecule inhibitors challenged the Nef allelome in competition assays. In contrast to single-variant inhibition, structurally simpler molecules could better inhibit the Nef allelome. Additionally, Nef sequences selected for binding to p53 resembled sequences from patients with a rapid progression to AIDS phenotype. Thus, the allelome versus small-molecule library approach offers a route for improving antiviral drug discovery and elucidating fundamental mechanisms of viral pathogenesis and resistance.
Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex (2010)

Following sinoaortic denervation, which eliminates arterial baroreceptor input into the brain, there are slowly developing adaptations that abolish initial sympathetic activation and hypertension. In comparison, electrical stimulation of the carotid sinus for 1 wk produces sustained reductions in sympathetic activity and arterial pressure. However, whether compensations occur subsequently to diminish these responses is unclear. Therefore, we determined whether there are important central and/or peripheral adaptations that diminish the sympathoinhibitory and blood pressure-lowering effects of more sustained carotid sinus stimulation. To this end, we measured whole body plasma norepinephrine spillover and alpha(1)-adrenergic vascular reactivity in six dogs over a 3-wk period of baroreflex activation. During the first week of baroreflex activation, there was an approximately 45% decrease in plasma norepinephrine spillover, along with reductions in mean arterial pressure and heart rate of approximately 20 mmHg and 15 beats/min, respectively; additionally, plasma renin activity did not increase. Most importantly, these responses during week 1 were largely sustained throughout the 3 wk of baroreflex activation. Acute pressor responses to alpha-adrenergic stimulation during ganglionic blockade were similar throughout the study, indicating no compensatory increases in adrenergic vascular reactivity. These findings indicate that the sympathoinhibition and lowering of blood pressure and heart rate induced by chronic activation of the carotid baroreflex are not diminished by adaptations in the brain and peripheral circulation. Furthermore, by providing evidence that baroreflexes have long-term effects on sympathetic activity and arterial pressure, they present a perspective that is opposite from studies of sinoaortic denervation.
Bispecific T Cell Engagers for the Treatment of Multiple Myeloma: Achievements and Challenges (2021)

MM is the second most common hematological malignancy and represents approximately 20% of deaths from hematopoietic cancers. The advent of novel agents has changed the therapeutic landscape of MM treatment; however, MM remains incurable. T cell-based immunotherapy such as BTCEs is a promising modality for the treatment of MM. This review article discusses the advancements and future directions of BTCE treatments for MM.
An interferon-gamma (IFN-gamma) based whole blood assay to detect T cell response to antigens in HIV-1 infected patients. (1997)

Recently it has been reported that cytokine production by T cells in response to antigens may be more sensitive test than lymphoproliferation. T cell reactivities to antigens is usually performed on isolated PBMCs, however whole blood is being used frequently for cytokine production studies. A whole blood assay is described to measure T cell mediated immune responses to HIV-1 and recall antigens. The cultures were performed in 96-well plates in which only 25 microliters of whole blood was required. We studied the production of IFN gamma in short term culture (24 hours) of 1/10 diluted heparinized whole blood (HWB) from 22 HIV-1 (+) patients grouped according to the 1993 classification of the CDC. IFN gamma was measured with an immunoassay in supernatants of HWB cultured in parallel experiments in the presence of supernatant of HIV-1LAI infected CD4+ T cells, p24 HIV antigen, PPD, tetanus toxoid (TET) and PHA. We found no production of IFN gamma in response to HIV-1 antigens in 15 HIV-1 (-) subjects; whereas a specific IFN gamma production in the presence of HIV-1 antigen was obtained in all of the 9 group A patients, in 7 of 8 group B patients and in 2 of 5 group C patients. In response to recall antigens (TET, PPD), we obtained IFN gamma production in 6 of 9 group A patients, 5 of 8 group B patients and in 1 of 5 group C patients, the response to PHA decreased but remained preserved until late in the disease. The HWB assay is a quick and simple potentially valuable tool for assessing cellular immune function in HIV-1+ patients.
A Recursive Wavelet-Based Strategy for Real-Time Cochlear Implant Speech Processing on PDA Platforms (2010)

This paper presents a wavelet-based speech coding strategy for cochlear implants. In addition, it describes the real-time implementation of this strategy on a personal digital assistant (PDA) platform. Three wavelet packet decomposition tree structures are considered and their performance in terms of computational complexity, spectral leakage, fixed-point accuracy, and real-time processing are compared to other commonly used strategies in cochlear implants. A real-time mechanism is introduced for updating the wavelet coefficients recursively. It is shown that the proposed strategy achieves higher analysis rates than the existing strategies while being able to run in real time on a PDA platform. In addition, it is shown that this strategy leads to a lower amount of spectral leakage. The PDA implementation is made interactive to allow users to easily manipulate the parameters involved and study their effects.
How to simulate 1000 cores (2009)

This paper proposes a novel methodology to efficiently simulate shared-memory multiprocessors composed of hundreds of cores. The basic idea is to use thread-level parallelism in the software system and translate it into corelevel parallelism in the simulated world. To achieve this, we first augment an existing full-system simulator to identify and separate the instruction streams belonging to the different software threads. Then, the simulator dynamically maps each instruction flow to the corresponding core of the target multi-core architecture, taking into account the inherent thread synchronization of the running applications. Our simulator allows a user to execute any multithreaded application in a conventional full-system simulator and evaluate the performance of the application on a many-core hardware. We carried out extensive simulations on the SPLASH-2 benchmark suite and demonstrated the scalability up to 1024 cores with limited simulation speed degradation vs. the single-core case on a fixed workload. The results also show that the proposed technique captures the intrinsic behavior of the SPLASH-2 suite, even when we scale up the number of shared-memory cores beyond the thousand-core limit.
System Level Integration of Irregular Repetition Slotted ALOHA for Industrial IoT in 5G New Radio (2019)

Automation is a key part of the new industrial revolution, that will be enabled by the deployment of thousands of sensors and actuators. The flexible deployment of these devices requires wireless connectivity which is labeled as industrial internet of things, IIoT. The sporadic activity pattern of IIoT devices naturally suggest the use of random access techniques, albeit posing new and unexplored challenges for the current wireless networks. On top of the demand for new access protocols, the latency-reliability requirements further challenge the existing random access protocols. In this work we investigate the adaptation of a well known modern random access algorithm, Irregular Repetition Slotted ALOHA (IRSA) to IIoT in 5G New Radio. The key contribution of the paper is the proposed system level protocol, Adaptive-Multichannel IRSA, that can fulfill the latency-reliability requirements. On top of this, the definition and solution of the resource allocation problem as a resource efficiency optimization guarantees that the algorithm minimizes the system resources. We show that for a set of specific requirements, AMC-IRSA can fulfill the requirements in a lot resource efficient manner. Lastly, we analyze most critical parameters to consider for integration of IRSA for 5G NR.
ChemInform Abstract: Total Asymmetric Synthesis of Taxol by Dehydration Condensation Between 7‐TES Baccatin III and Protected N‐Benzoylphenylisoserines Prepared by Enantioselective Aldol Reaction. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Systematic stress testing of image quality estimators (2011)

We present a methodology to systematically stress objective image quality estimators (QEs). Using computational results instead of expensive subjective tests, we obtain rigorous information of a QE's performance on a constrained but comprehensive set of degraded images. Our process quantifies many of a QE's potential vulnerabilities. Knowledge of these weaknesses can be used to improve a QE during its design process, to assist in selecting which QE to deploy in a real system, and to interpret the results of a chosen QE once deployed.
MeLPUF: Memory in Logic PUF. (2020)

Physical Unclonable Functions (PUFs) are used for securing electronic designs across the implementation spectrum ranging from lightweight FPGA to server-class ASIC designs. However, current PUF implementations are vulnerable to model-building attacks; they often incur significant design overheads and are challenging to configure based on application-specific requirements. These factors limit their application, primarily in the case of the system on chip (SoC) designs used in diverse applications. In this work, we propose MeL-PUF - Memory-in-Logic PUF, a low-overhead, distributed, and synthesizable PUF that takes advantage of existing logic gates in a design and transforms them to create cross-coupled inverters (i.e. memory cells) controlled by a PUF control signal. The power-up states of these memory cells are used as the source of entropy in the proposed PUF architecture. These on-demand memory cells can be distributed across the combinational logic of various intellectual property (IP) blocks in a system on chip (SoC) design. They can also be synthesized with a standard logic synthesis tool to meet the area,power, or performance constraints of a design. By aggregating the power-up states from multiple such memory cells, we can create a PUF signature or digital fingerprint of varying size. We evaluate the MeL-PUF signature quality with both circuit-level simulations as well as with measurements in FPGA devices. We show that MeL-PUF provides high-quality signatures in terms of uniqueness, randomness, and robustness, without incurring large overheads. We also suggest additional optimizations that can be leveraged to improve the performance of MeL-PUF.
Room-temperature Preparation of &#946;-FeSi&gt;inf&lt;2&gt;/inf&lt;Microdroplets-containing Films via Excimer Laser Deposition and Annealing (2006)

Room-temperature fabrication of a β-FeSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> microdroplets-containing film was achieved by the active use of micro-droplets. Successive laser annealing increased the Raman intensity from the β-FeSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> droplets up to fivefold, indicating further improvement in crystallinity.
ChemInform Abstract: Evidence that Palladium(0)‐Promoted Cyclizations of Unsaturated α‐Iodo Carbonyls Occur by an Atom Transfer Mechanism. (1990)

Abstract Various unsaturated iodo esters are irradiated in the presence of hexabutyldistannane or treated with a palladium(0) complex to undergo ring closure.
Telomere Lengths in Cloned Transgenic Pigs1 (2004)

Studies of cloned cattle and mice have resulted in controversies regarding the restoration of eroded telomere length of donor cells by the nuclear transfer process. Little is known about telomere lengths in pigs from either natural reproduction or nuclear transfer. In this study, we measured the telomere lengths in six major porcine organs from animals of different ages, and found that their lengths remained consistent throughout different tissues during fetal stages, and then shortened, in a tissue- specific manner, after birth. Telomeres of skin samples from six cloned transgenic pigs at 4 mo of age did not differ significantly from those of age-matched controls. Two cloned pigs that died shortly after birth had skin telomere lengths equivalent to those of late-stage fetuses.
Cortex registration: a geometric approach (2005)

We have devised and implemented a novel method for calculating the high dimensional field relating the brain surfaces (cortex) of an arbitrary pair of subjects. This non-rigid registration method uses crest lines as anatomical landmarks and various geometrical techniques such as geodesic voronoi diagram, barycentric flattening and barycentric coordinates to partition the cortex into meaningful regions and achieve a spatially accurate matching. Finally, the multilevel B-splines method is used to compute a <i>C</i><sup>2</sup> continuous warping field.
Photodynamic transport of metal ions (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodynamic transport of metal ionsJeffrey D. Winkler, Kurt Deshayes, and Bin ShaoCite this: J. Am. Chem. Soc. 1989, 111, 2, 769–770Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00184a076https://doi.org/10.1021/ja00184a076research-articleACS PublicationsRequest reuse permissionsArticle Views326Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro (2009)

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Ethanol Decreases Cytosolic‐Free Calcium Ions in Vascular Smooth Muscle Cells As Assessed by Digital Image Analysis (1992)

Effects of ethanol on intracellular-free Ca2+ concentration in cultured rat aortic smooth muscle cells were examined by digital imaging fluorescence microscopy using the Ca2+ fluorescence indicator, fura-2. Ethanol induced dose-dependent decrements in cytosolic-free Ca2+ concentration at 45 mM and 90 mM, which was consistent with previously reported observations of relaxation in intact rat aortic tissues. However, ethanol at high pharmacological concentrations (e.g., 450 mM) failed to induce any further inhibition in cytosolic-free Ca2+ concentration. Our results suggest that the vasodilator effects of ethanol, observed on intact blood vessels, may result in part from an interference with the availability of Ca2+ for excitation-contraction coupling in vascular smooth muscle cells.
Experimental validation of analytical performance models for IEEE 802.11 networks (2010)

We consider the simplest IEEE 802.11 WLAN networks for which analytical models are available and seek to provide an experimental validation of these models. Our experiments include the following cases: (i) two nodes with saturated queues, sending fixed-length UDP packets to each other, and (ii) a TCP-controlled transfer between two nodes. Our experiments are based entirely on Aruba AP-70 access points operating under Linux. We report our observations on certain non-standard behavior of the devices. In cases where the devices adhere to the standards, we find that the results from the analytical models estimate the experimental data with a mean error of 3-5%.
CARP-1 / CCAR1: A biphasic regulator of cancer cell growth and apoptosis (2015)

Targeted cancer therapy using small molecule inhibitors (SMIs) has been useful in targeting the tumor cells while sparing the normal cells. Despite clinical success of many targeted therapies, their off-target effects and development of resistance are emerging as significant and challenging problems. Thus, there is an urgent need to identify targets to devise new means to treat cancers and their drug-resistant phenotypes. CARP-1/CCAR1 (Cell division cycle and apoptosis regulator 1), a peri-nuclear phospho-protein, plays a dynamic role in regulating cell growth and apoptosis by serving as a co-activator of steroid/thyroid nuclear receptors, β-catenin, Anaphase Promoting Complex/Cyclosome (APC/C) E3 ligase, and tumor suppressor p53. CARP-1/CCAR1 also regulates chemotherapy-dependent apoptosis. CARP-1/CCAR1 functional mimetics (CFMs) are a novel SMIs of CARP-1/CCAR1 interaction with APC/C. CFMs promote apoptosis in a manner independent of p53. CFMs are potent inhibitors of a variety of cancer cells including the drug (Adriamycin or Tamoxifen)-resistant breast cancer cells but not the immortalized breast epithelial cells, while a nano-lipid formulation of the lead compound CFM-4 improves its bioavailability and efficacy in vivo when administered orally. This review focuses on the background and pleiotropic roles of CARP-1/CCAR1 as well as its apoptosis signaling mechanisms in response to chemotherapy in cancer cells.
An energy-efficient IEEE 802.15.4 tunable digital baseband targeting self-adaptive WPANs (2015)

The emerging market of the Internet of Things is constrained by the energy-efficiency of each layers having a role in Wireless Personal Area Networks (WPANs). In this context, adaptivity is a key technique to address the need of low-power consumption in unpredictable environments, by providing at any time a low-margin operating mode. For this purpose, the paper presents an IEEE 802.15.4 digital baseband with a tunable computation subsampling mechanism built-in. The described architecture, simulated in a 65 nm LP-CMOS process, drains only 82.9 μA in average at its best operating point against 208 μA in normal mode. Thus, it enables a power consumption reduction of up to 58 % that can be exploited in case of favorable receiving conditions, as part of a self-adaptive wireless network.
Three-Dimensional Wafer Stacking Using Cu TSV Integrated with 45 nm High Performance SOI-CMOS Embedded DRAM Technology (2014)

For high-volume production of 3D-stacked chips with through-silicon-vias (TSVs), wafer-scale bonding offers lower production cost compared with bump bond technology and is promising for interconnect pitches smaller than 5 µ using available tooling. Prior work has presented wafer-scale integration with tungsten TSV for low-power applications. This paper reports the first use of low-temperature oxide bonding and copper TSV to stack high performance cache cores manufactured in 45 nm Silicon On Insulator-Complementary Metal Oxide Semiconductor (SOI-CMOS) embedded DRAM (EDRAM) having 12 to 13 copper wiring levels per strata and upto 11000 TSVs at 13 µm pitch for power and signal delivery. The wafers are thinned to 13 µm using grind polish and etch. TSVs are defined post bonding and thinning using conventional alignment techniques. Up to four additional metal levels are formed post bonding and TSV definition. A key feature of this process is its compatibility with the existing high performance POWER7™ EDRAM core requiring neither modification of the existing CMOS fabrication process nor re-design since the TSV RC characteristic is similar to typical 100–200 µm length wiring load enabling 3D macro-to-macro signaling without additional buffering Hardware measurements show no significant impact on device drive and off-current. Functional test at wafer level confirms 2.1 GHz 3D stacked EDRAM operation.
The whole genome sequences and experimentally phased haplotypes of over 100 personal genomes (2016)

These genomes represent a unique source of haplotype and phenotype data for the scientific community and should help to expand our understanding of human genome evolution and function.