gebhart/patrepeval huggingface dataset:
Identification of androgen receptor phosphorylation in the primate ovary in vivo (2010)

The androgen receptor (AR) is a member of the nuclear receptor superfamily, and is important for both male and female reproductive health. The receptor is a target for a number of post-translational modifications including phosphorylation, which has been intensively studied in vitro. However, little is known about the phosphorylation status of the receptor in target tissues in vivo. The common marmoset is a useful model for studying human reproductive functions, and comparison of the AR primary sequence from this primate shows high conservation of serines known to be phosphorylated in the human receptor and corresponding flanking amino acids. We have used a panel of phosphospecific antibodies to study AR phosphorylation in the marmoset ovary throughout the follicular phase and after treatment with GNRH antagonist or testosterone propionate. In normal follicular phase ovaries, total AR (both phosphorylated and non-phosphorylated forms) immunopositive staining was observed in several cell types including granulosa cells of developing follicles, theca cells and endothelial cells lining blood vessels. Receptor phosphorylation at serines 81, 308, and 650 was detected primarily in the granulosa cells of developing follicles, surface epithelium, and vessel endothelial cells. Testosterone treatment lead to a modest increase in AR staining in all stages of follicle studied, while GNRH antagonist had no effect. Neither treatment significantly altered the pattern of phosphorylation compared to the control group. These results demonstrate that phosphorylation of the AR occurs, at a subset of serine residues, in a reproductive target tissue in vivo, which appears refractory to hormonal manipulations.
Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor (2010)

Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX fusion proteins, a complement-regulatory peptide (COMPinh). These novel Ads dramatically minimize Ad-dependent activation of the human and non-human primate complement systems, as determined by several assays. In summary, our work has shown that a novel COMPinh-displaying Ad5 has the potential for broadening the safe use of Ad vectors in future human applications.
1,2,4‐Triazines (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Bandwidth-Efficient Coded Modulation Schemes for Physical-Layer Network Coding with High-Order Modulations (2016)

This paper presents several soft decision iterative decoding schemes for physical-layer network coding (PNC) operated with coded modulation (CM) and bit-interleaved coded modulation (BICM). With respect to PNC operated with CM, we consider network coding-based channel decoding (NC-CD) and multi-user complete decoding (MUD-NC) for PNC decoding at the relay. Their BICM counterparts are XOR-based channel decoding (XOR-CD) and MUD-XOR, respectively. First, we show that, when the decoding is non-iterative, there is a gap between the BICM capacities of both XOR-CD and MUD-XOR under Gray mapping and the capacities of their CM counterparts, NC-CD, and MUD-NC. This is in contrast to the conventional point-to-point communication system, for which the BICM capacity with Gray mapping is known to be very close to the CM capacity, without the need for iterative decoding. Second, we investigate the error performance of iteratively decoded BICM XOR-CD and MUD-XOR. Extrinsic information transfer chart analysis and simulation results indicate that for these Gray-mapped BICM PNC systems, iterative decoding can achieve considerable gains over non-iterative decoding. Again, this is in contrast to the Gray-mapped BICM point-to-point communication system, for which iterative decoding provides little gain over non-iterative decoding. We further show that Gray mapping gives rise to best PNC rate for MUD-XOR and XOR-CD systems among several bits-to-symbol mappings under study. Overall, our results indicate that BICM PNC systems exhibit different decoding behavior from conventional BICM point-to-point systems. This paper serves as a first foray into the investigation of this issue.
ChemInform Abstract: Platelet Glycoprotein IIb/IIIa Receptor Antagonists Derived from Isoxazolidines. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Medium-wavelength infrared gas sensing with electrochemically fabricated porous silicon optical rugate filters (2011)

Porous silicon optical rugate filters are electrochemically fabricated to display reflectance peaks in the medium-wavelength infrared (MWIR) region from 4 to 8 μm. Etching conditions are adjusted to create filters with single and multiple infrared reflectance peaks overlapping specific infrared chemical absorbance bands. Additional infrared reflectance peaks are designed into the structures to provide internal optical reference channels. Samples containing optical reflectance features matching the absorbance band of CO2 at 2350 cm−1 are used to demonstrate gas sensing with optical filters, and a structure with a photonic stop band tuned to match the infrared absorbance band of the P=O functional group, found in G-series chemical warfare agents, is fabricated. With adequate electrolyte replenishment, the calibrated etch conditions generated reproducible spectral band features even for relatively long etch durations. This work represents the first example of a porous Si spectral filter prepared to match specific spectral features of molecules in the MWIR ("fingerprint") region.
Abstract 1015: Directionality of T-cell-mediated cross-protection against the same tumor in lungs versus skin (2017)

Abstract Immunotherapy is a new pillar of cancer therapy. One theoretical advantage of immunotherapy of cancer is that effector cells induced at one site should be able to kill metastatic cancer cells in other sites or tissues. On the other hand, it has been recognized that each tissue has unique immune components that play critical roles in protection against pathogens. However, very little is known whether effector T cells induced against tumors in one tissue can work against the same tumors in other tissues. To address this question, we compared the effect of effector cells induced against the same tumor cells growing in either the skin or the lung by using CT26 murine tumor models. Rejection of s.c. CT26 tumors was achieved by pretreatment with anti-CD25, which blocks the function of Treg cells. Both CD4 and CD8 T cells were necessary for the protection. When anti-CD25-pretreated mice challenged with s.c. CT26 were simultaneously inoculated i.v. with CT26, they also rejected tumors in the lung, while anti-CD25-pretreated mice without s.c. CT26 did not. This observation suggested that T cell mediated anti-tumor protective immunity induced against s.c. tumors can also protect against lung metastases of the same tumors. In contrast to Treg depletion which allowed for the induction of protective immunity in the s.c. tumor model, NKT cell-deficiency in CD1d KO mice induced significant CD8 T cell-mediated protection against lung metastasis of CT26 but had no effect on the growth of s.c. CT26 tumors. When CD1d KO mice rejecting i.v. CT26 were simultaneously challenged with s.c. CT26, the development of s.c. tumors was not affected, indicating that tumor rejection induced against the CT26 in the lung did not confer protection for the same tumor cells in the skin. Since the protection against CT26 in the lung in CD1d KO mice is mediated by CD8 T cells, we transferred T cells from CD1d KO mice inoculated i.v. with CT26 into RAG1 KO recipients, and challenged the recipient mice with the CT26 tumor cells. The recipient RAG1 KO mice were highly resistant to CT26 inoculated i.v. but not s.c. confirming that the CD8 T cells protective in the lung are not protective in the skin. These data indicate the effector cells against the same tumor do not work in all tissues, and the induction site of the effector T cells is critical to control metastasis. Citation Format: Jessica J. O'Konek, Elena Ambrosino, Anja Bloom, Liat Izhak, Jay A. Berzofsky, Masaki Terabe. Directionality of T-cell-mediated cross-protection against the same tumor in lungs versus skin [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1015. doi:10.1158/1538-7445.AM2017-1015
The hepatic microsomal glucose-6-phosphatase stabilizing protein is a calcium-binding protein (1987)

Conference Article| December 01 1987 The hepatic microsomal glucose-6-phosphatase stabilizing protein is a calcium-binding protein IAN D. WADDELL; IAN D. WADDELL 1Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANN BURCHELL ANN BURCHELL * *To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (6): 1126–1127. https://doi.org/10.1042/bst0151126 Article history Received: June 06 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation IAN D. WADDELL, ANN BURCHELL; The hepatic microsomal glucose-6-phosphatase stabilizing protein is a calcium-binding protein. Biochem Soc Trans 1 December 1987; 15 (6): 1126–1127. doi: https://doi.org/10.1042/bst0151126 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: SDS-PAGE, SDS-polyacrylamide gel electrophoresis This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
Sevoflurane and Anesthesia for Neurosurgery (2000)

This review assesses the extent to which sevoflurane fulfills the requirements of the ideal inhalational agent for use in neuroanesthetic practice. Sevoflurane's pharmacokinetic profile is outlined. Data from animal and human studies are used to discuss its effects on cerebral hemodynamics, central nervous system monitoring, and cardiovascular parameters. Where possible, sevoflurane is compared with isoflurane, currently considered the inhalational agent of choice in neuroanesthesia. Sevoflurane's potential for toxicity is reviewed.
Electrodipping Force Acting on Solid Particles at a Fluid Interface (2004)

We report experimental results which show that the interfacial deformation around glass particles (radius, 200-300 microm) at an oil-water (or air-water) interface is dominated by an electric force, rather than by gravity. It turns out that this force, called for brevity "electrodipping," is independent of the electrolyte concentration in the water phase. The force is greater for oil-water than for air-water interfaces. Under our experimental conditions, it is due to charges at the particle-oil (instead of particle-water) boundary. The derived theoretical expressions, and the experiment, indicate that this electric force pushes the particles into water. To compute exactly the electric stresses, we solved numerically the electrostatic boundary problem, which reduces to a set of differential equations. Convenient analytical expressions are also derived. Both the experimental and the calculated meniscus profile, which are in excellent agreement, exhibit a logarithmic dependence at long distances. This gives rise to a long-range electric-field-induced capillary attraction between the particles, detected by other authors. Deviation from the logarithmic dependence is observed at short distances from the particle surface due to the electric pressure difference across the meniscus. The latter effect gives rise to an additional short-range contribution to the capillary interaction between two floating particles. The above conclusions are valid for either planar or spherical fluid interfaces, including emulsion drops. The electrodipping force, and the related long-range capillary attraction, can engender two-dimensional aggregation and self-assembly of colloidal particles. These effects could have implications for colloid science and the development of new materials.
Specificity of chicken secondaryin vitrolymphoproliferative responses to a parakeet isolate of avian paramyxovirus‐3 (1988)

Partially inbred chickens of the Birmingham B2 subline were primed with Paramyxovirus-3/parakeet/Netherlands/449/1975 (PMV 449), and secondary in vitro spleen cell responses were investigated with respect to virus specificity and histocompatibility restriction. PMV 449-primed spleen cells responded to stimulation with syngeneic lymphocytes infected with PMV 449 and other avian paramyxoviruses of the same serogroup, and showed a low level of cross-reaction with Newcastle disease virus. Yucaipa (PMV-2) and Sendai virus were not recognised. Normal Birmingham B2 spleen cells were unresponsive to stimulation with virus-infected lymphocytes. PMV 449-primed spleen cells also responded to stimulation with virus-infected allogeneic lymphocytes under conditions which excluded alloantigen-specific mixed lymphocyte reactions. Possible reasons for the apparent lack of histocompatibility restriction are discussed.
Final report of the key comparison CCQM-K88: Determination of lead in lead-free solder containing silver and copper (2012)

The CCQM-K88 key comparison was organized by the Inorganic Analysis Working Group of CCQM to test the abilities of the national metrology institutes to measure the mass fraction of lead in lead-free solder containing silver and copper. National Metrology Institute of Japan (NMIJ), National Institute of Metrology of China (NIM) and Korea Research Institute of Standards and Science (KRISS) acted as the coordinating laboratories. The participants used different measurement methods, though most of them used inductively coupled plasma optical emission spectrometry (ICP-OES) or isotope-dilution inductively coupled plasma mass spectrometry (ID-ICP-MS). Accounting for relative expanded uncertainty, comparability of measurement results was successfully demonstrated by the participating NMIs for the measurement of the mass fraction of lead in lead-free solder at the level of 200 mg/kg. It is expected that metals at mass fractions greater than approximately 100 mg/kg in lead-free solder containing silver and copper can be determined by each participant using the same technique(s) employed for this key comparison to achieve similar uncertainties mentioned in the present report. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
A design kit for a fully working shared memory multiprocessor on FPGA (2007)

This paper presents a framework to design a shared memory multiprocessor on a programmable platform. We propose a complete flow, composed by a programming model and a template architecture. Our framework permits to write a parallel application by using a shared memory model. It deals with the consistency of shared data, with no need of hardware coherence protocol, but uses a software model to properlyallsynchronize the local copies with the shared memory image. This idea can be applied both to a scratchpad-based architecture or a cache-based one. The architecture is synthesizable with standard IPs, such as the softcores and interconnect elements, which may be found in any commercial FPGA toolset.
New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug (2007)

A carrier-free method for delivery of a hydrophobic drug in its pure form, using nanocrystals (nanosized crystals), is proposed. To demonstrate this technique, nanocrystals of a hydrophobic photosensitizing anticancer drug, 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH), have been synthesized using the reprecipitation method. The resulting drug nanocrystals were monodispersed and stable in aqueous dispersion, without the necessity of an additional stabilizer (surfactant). As shown by confocal microscopy, these pure drug nanocrystals were taken up by the cancer cells with high avidity. Though the fluorescence and photodynamic activity of the drug were substantially quenched in the form of nanocrystals in aqueous suspension, both these characteristics were recovered under in vitro and in vivo conditions. This recovery of drug activity and fluorescence is possibly due to the interaction of nanocrystals with serum albumin, resulting in conversion of the drug nanocrystals into the molecular form. This was confirmed by demonstrating similar recovery in presence of fetal bovine serum (FBS) or bovine serum albumin (BSA). Under similar treatment conditions, the HPPH in nanocrystal form or in 1% Tween-80/water formulation showed comparable in vitro and in vivo efficacy.
A General Approach for the Hydroxy Group Functionalization of Synthetic Oligonucleotides (1995)

Abstract Generally applicable non-nucleosidic solid supports and phosphoramidite building blocks that enable attachment of various tethers to the hydroxy groups of oligonucleotides were prepared. The key feature of the structure of these reagents is an ester bond of moderate reactivity which allows postsynthetic introduction of tethers by reaction with substituted alkylamines.
Reaction of dicyclopentadienylmethylenetitanium with organic halides: Evidence for a radical mechanism (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of dicyclopentadienylmethylenetitanium with organic halides: Evidence for a radical mechanismStephen L. Buchwald, Eric V. Anslyn, and Robert H. GrubbsCite this: J. Am. Chem. Soc. 1985, 107, 6, 1766–1768Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00292a056https://doi.org/10.1021/ja00292a056research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influenza A Viruses of Migrating Wild Aquatic Birds in North America (2004)

Surveillance of North America's wild ducks and shorebirds for 26 and 16 years, respectively, revealed differences in the prevalence of orthomyxoviruses between these hosts. Shorebirds had a high frequency of influenza A virus isolation during their northern migration, while wild ducks had high virus isolation frequencies during their southern migration. Some subtypes of influenza occurred regularly in both hosts with a 2-year periodicity, whereas others rarely occurred. Hemagglutinin subtypes H1 through H12 occurred in both hosts; H13 occurred only in shorebirds; and H14, H15, and influenza B and C never were detected. Shorebirds manifested a broader range of subtypes suggesting that shorebirds are the leading source of some viruses (such as H5) which are isolated less frequently from wild ducks. The viruses reported in this study are available for genomic study to determine whether prediction of host range or pandemic potential is possible.
Precise structure activity relationships in asymmetric catalysis using carbohydrate scaffolds to allow ready fine tuning: dialkylzinc–aldehyde additions (2003)

The ready construction of 24 stereochemically and functionally diverse carbohydrate ligand structures from a core D-glucosamine scaffold has allowed the evaluation of broad ranging structure activity relationships in ligand accelerated zincate additions to aldehydes, with variations in deltadeltaG+/+(R-S) of up to 5650 J mol(-1) that create opposing senses of asymmetric induction and that are consistent with models based on several ligand X-ray structures and molecular mechanics analysis. Factorial analysis of enantioselectivity using key dihedral angles and steric volume on N-2 also highlight the potential for the use of factorial design in ligand construction.
Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis (2020)

Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO<sub>2</sub> nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts.