gebhart/patrepeval huggingface dataset:
Structural similarities between the mammalian beta-adrenergic and reovirus type 3 receptors. (1985)

The mechanism by which viruses bind to and infect specific tissues to cause disease has only recently begun to be understood. The mammalian reoviruses provide an especially attractive model for studying the details of cell surface recognition. The cell and tissue tropism of reovirus is determined by a portion of the viral hemagglutinin termed the neutralization domain. We have reported previously on the generation of both monoclonal and polyclonal anti-idiotypic antibodies that mimic the viral hemagglutinin in the specificity of binding to the reovirus receptor. By using these anti-idiotypic antibodies as specific probes, we have successfully isolated the mammalian reovirus receptor from neuronal and lymphoid cells. In the present study, we report that the reovirus receptor is structurally similar to the mammalian beta-adrenergic receptor. This conclusion is based on the following observations: (i) purified beta-adrenergic receptor is immunoprecipitable by anti-reovirus receptor antibody; (ii) purified reovirus receptor obtained from murine thymoma cells and beta-adrenergic receptor obtained from calf lung exhibit identical molecular masses and isoelectric points; (iii) trypsin digests of purified reovirus and beta-adrenergic receptors display indistinguishable fragment patterns; (iv) purified reovirus receptor binds the beta-antagonist [125I]iodohydroxybenzylpindolol and this binding is blocked by the beta-agonist isoproterenol.
Characterization of V-W and Mo-W Mixed Oxide Catalysts for the Selective Oxidation of Acrolein to Acrylic Acid (2007)

The ternary Mo-W and V-W mixed oxides are part of the quaternary V-Mo-W catalyst system which is highly active and selective for the important and widely used selective oxidation of acrolein to acrylic acid. Both subsystems are active and selective catalysts for this reaction, varying with composition. The microstructure of the samples has been identified as homogeneously distributed nanocrystalline grains within the shell of the hollow balls that are typical for the spray-drying process. The crystallite sizes differ between the two sample series and depend on the composition as well. The test for the catalytic performance revealed the highest selectivity and yield in acrylic acid production for the V-W catalyst with 70% tungsten content, although tungsten oxide is known to be chemically inactive. The active components vanadium oxide and molybdenum oxide presumably are the most selective for the reaction of acrolein to acrylic acid when their structure and cluster size is stabilized by a stable and inert WO 3 matrix. The heating of the samples during the catalytic performance test caused a visible growth of the nanocrystallites which also protruded from the surface of the hollow balls. The structural rearrangements led to an increase of the catalytic performance.
ChemInform Abstract: SYNTHESIS OF SOME CYCLOPROPYL‐Γ‐LACTONES AS ANALOGS OF CYTOTOXIC α‐METHYLENE‐Γ‐LACTONES (1979)

Abstract Im Zusammenhang mit der cytotoxischen Aktivität natürlicher Terpene, die ein α‐Methylen‐y‐lacton als biologisch aktive Einheit enthalten, werden zur Untersuchung der Struktur‐Aktivitäts‐Beziehung die cx‐Cyclopropyl‐y‐lactone (V), (XI) und (XV) sowie die Analogen (XVIII) synthetisiert.
Diastereoselective Synthesis of theC 2-Symmetric 2,3-Diaminotetralin via Electrophilic Amination (1994)

Starting from the N,N-dibenzyl protected ß-amino acid 3 a synthesis of the C 2-symmetric racemic 2,3-diaminotetralin (4; 2,3- diamino-1,2,3,4-tetrahydronaphthalene) is reported. The key step of the procedure is a highly stereocontrolled electrophilic amination by dibenzyl azodicarboxylate.
Isolated Growth Hormone Deficiency in Chilean Patients: Clinical and Molecular Analysis (2003)

Isolated growth hormone deficiency (IGHD) is a disorder that leads to short stature. It has been classified into types IA, IB, II and III. GH gene mutations and growth hormone releasing hormone (GHRH) receptor gene mutations have been described in patients with IGHD. We report here a clinical and molecular study of 27 Chilean patients with IGHD. We performed GH stimulation tests with GHRH and GHRP, and segregation and molecular analysis of the GH, GHRH and GHRH receptor genes. We describe four patients with IGHD IA bearing a 7 kb mutation (13%), and two IGHD II patients who showed two different splice site point mutations (6.8%). In 21 patients, we did not find a mutation in any of the three genes examined. These results led us to conclude that the molecular causes of IGHD involve other genes besides those analyzed in this report, as has been reported previously in patients of different ethnic origins.
SOGOU-2012-CRAWL (2016)

In 2012, Sogou, a major Chinese web search engine released a large-scale query log containing 43.5M user interactions, including submitted queries and clicked web page search results. This query log offers a deep sample of queries over a two day period from 30th December 2011 to 1st January 2012. In August 2013, we identified 1.4M predominantly Chinese language unique search result URLs that were clicked at least three times in this query log. We crawled the HTML content of these URLs to construct the supplementary SOGOU-2012-CRAWL dataset, which we release in this work. A real large-scale query log with accompanying crawl such as this offers several opportunities for reproducible information retrieval (IR) research, including query classification, intent modelling and indexing strategy. In this paper we first detail the query log and crawl dataset construction and characteristics. Following this, to demonstrate potential applications we use the crawl to indicatively analyse various time-based patterns in web content and search behaviour. In particular, we study the distribution of language-independent date expressions in the crawled web content. Based on this, we propose a simple approach for modelling the past/present/future temporal intent of queries based on the date the query was submitted by the user, and the dates appearing in the clicked search results. We observe several prominent temporal patterns which may lead to novel time-aware IR approaches.
Bouquet-type Dendrimerlike Poly(ethylene Oxide)s with a Focal Aldehyde and Peripheral Hydroxyls (2007)

Doubly functionalized dendrimerlike poly(ethylene oxide)s (PEOs) carrying 16 hydroxyl groups at their periphery and one aldehyde group at their focal point were synthesized up to the fourth generation through an iterative divergent approach. First, a protected aldehyde dihydroxyl compound, namely, 3,3-diethoxy-1,2-propanediol, was used as initiator for the anionic ring-opening polymerization (AROP) of ethylene oxide after partial deprotonation (30%) in dimethyl sulfoxide. The two hydroxyls carried by the PEO chain ends of the first generation were subsequently derivatized so as to generate four hydroxyls via a two-step reaction (allylation and osmylation). The next generations of such dendrimerlike PEOs were grown upon repeating the same cycle of AROP and chain-end modification. At the completion of these reactions, the acetal group present at the core was deprotected under acidic conditions to afford the targeted dendrimerlike PEO of fourth generation with a central aldehyde group. The reactivity and accessibility of the latter function was demonstrated upon its conjugation with aniline used as a model compound.
Klf4 has an unexpected protective role in perivascular cells within the microvasculature (2018)

Recent smooth muscle cell (SMC) lineage-tracing studies have revealed that SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that Kruppel-like factor 4 (KLF4) in SMCs is detrimental for overall lesion pathogenesis, in that SMC-specific conditional knockout of the KLF4 gene ( Klf4) resulted in smaller, more-stable lesions that exhibited marked reductions in the numbers of SMC-derived macrophage- and mesenchymal stem cell-like cells. However, since the clinical consequences of atherosclerosis typically occur well after our reproductive years, we sought to identify beneficial KLF4-dependent SMC functions that were likely to be evolutionarily conserved. We tested the hypothesis that KLF4-dependent SMC transitions play an important role in the tissue injury-repair process. Using SMC-specific lineage-tracing mice positive and negative for simultaneous SMC-specific conditional knockout of Klf4, we demonstrate that SMCs in the remodeling heart after ischemia-reperfusion injury (IRI) express KLF4 and transition to a KLF4-dependent macrophage-like state and a KLF4-independent myofibroblast-like state. Moreover, heart failure after IRI was exacerbated in SMC Klf4 knockout mice. Surprisingly, we observed a significant cardiac dilation in SMC Klf4 knockout mice before IRI as well as a reduction in peripheral resistance. KLF4 chromatin immunoprecipitation-sequencing analysis on mesenteric vascular beds identified potential baseline SMC KLF4 target genes in numerous pathways, including PDGF and FGF. Moreover, microvascular tissue beds in SMC Klf4 knockout mice had gaps in lineage-traced SMC coverage along the resistance arteries and exhibited increased permeability. Together, these results provide novel evidence that Klf4 has a critical maintenance role within microvascular SMCs: it is required for normal SMC function and coverage of resistance arteries. NEW & NOTEWORTHY We report novel evidence that the Kruppel-like factor 4 gene ( Klf4) has a critical maintenance role within microvascular smooth muscle cells (SMCs). SMC-specific Klf4 knockout at baseline resulted in a loss of lineage-traced SMC coverage of resistance arteries, dilation of resistance arteries, increased blood flow, and cardiac dilation.
Liquid-Liquid Equilibria for Copolymer Mixtures from a Perturbed Hard-Sphere-Chain Equation of State (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-Liquid Equilibria for Copolymer Mixtures from a Perturbed Hard-Sphere-Chain Equation of StateToshiaki Hino, Yuhua Song, and John M. PrausnitzCite this: Macromolecules 1994, 27, 20, 5681–5690Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ma00098a023https://doi.org/10.1021/ma00098a023research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
N-Type Doping to an Active-Short Cavity DBR Laser to Expand Its Continuous Tuning Range (2008)

We propose the use of a short-cavity distributed Bragg reflector (DBR) laser with a modified active DBR structure, which has an n-type-doped active single quantum well, and that achieves fast wavelength switching that is potentially applicable for optical packet switching networks. The laser exhibits 6.4-nm continuous tuning by moderating a steep gain change at a low DBR injection current. Furthermore, 32-nm continuous tuning has also been achieved for an integrated laser with an eight-channel array.
Clonal hematopoiesis, somatic mosaicism, and age-associated disease (2022)

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the same tissue, is an evitable consequence of human aging. The hematopoietic system is no exception to this, where studies have revealed the presence of expanded blood cell clones carrying mutations in preleukemic driver genes and/or genetic alterations in chromosomes. This phenomenon is referred to as clonal hematopoiesis and is remarkably prevalent in elderly individuals. While clonal hematopoiesis represents an early step toward a hematological malignancy, most individuals will never develop blood cancer. Somewhat unexpectedly, epidemiological studies have found that clonal hematopoiesis is associated with an increase in the risk of all-cause mortality and age-related disease, particularly in the cardiovascular system. Studies using murine models of clonal hematopoiesis have begun to shed light on this relationship, suggesting that driver mutations in mature blood cells can causally contribute to aging and disease by augmenting inflammatory processes. Here we provide an up-to-date review of clonal hematopoiesis within the context of somatic mosaicism and aging and describe recent epidemiological studies that have reported associations with age-related disease. We will also discuss the experimental studies that have provided important mechanistic insight into how driver mutations promote age-related disease and how this knowledge could be leveraged to treat individuals with clonal hematopoiesis.
Synthesis, Photophysics, and Electrochemistry of Tetra(2‐thienyl)ethylene (TTE) Derivatives (Eur. J. Org. Chem. 33/2013) (2013)

The cover picture shows tetrathienylethene (TTE) and its derivatives, which, thanks to their peculiar shape, can be considered to be similar to butterflies. This similarity is displayed by the molecules lying on the white, yellow, and orange insects. The ethene core and the four thienyl rings mimic the body and the wings of the butterflies. The color of each butterfly reflects that of the corresponding molecule. The light-blue curve on which butterflies are flying represents the emission spectrum of TTE in the solid state and the color of its emission. Again, similar to butterflies, TTE and its derivatives are flexible, and “thienyl wings” can rotate to give rise to different conformations. details are discussed in the article by C. Baldoli, E. Licandro et al. on p. 7489 ff. The graphic was prepared by Lucia Bartolotta. The cover picture shows tetrathienylethene (TTE) and its derivatives, which, thanks to their peculiar shape, can be considered to be similar to butterflies. This similarity is displayed by the molecules lying on the white, yellow, and orange insects. The ethene core and the four thienyl rings mimic the body and the wings of the butterflies. The color of each butterfly reflects that of the corresponding molecule. The light-blue curve on which butterflies are flying represents the emission spectrum of TTE in the solid state and the color of its emission. Again, similar to butterflies, TTE and its derivatives are flexible, and “thienyl wings” can rotate to give rise to different conformations. details are discussed in the article by C. Baldoli, E. Licandro et al. on p. 7489 ff.
Identification and characterization of a tissue kallikrein in rat skeletal muscles (1987)

A tissue kallikrein was purified from rat skeletal muscle. Characterization of the enzyme showed that it has alpha-N-tosyl-L-arginine methylesterase activity and releases kinin from purified bovine low-Mr kininogen substrate. The pH optimum (9.0) of its esterase activity and the profile of inhibition by serine-proteinase inhibitors are identical with those of purified RUK (rat urinary kallikrein). Skeletal-muscle kallikrein also behaved identically with urinary kallikrein in a radioimmunoassay using a polyclonal anti-RUK antiserum. On Western-blot analysis, rat muscle kallikrein was recognized by affinity-purified monoclonal anti-kallikrein antibody at a position similar to that of RUK (Mr 38,000). Immunoreactive-kallikrein levels were measured in skeletal muscles which have different fibre types. The soleus, a slow-contracting muscle with high mitochondrial oxidative-enzyme activity, had higher kallikrein content than did the extensor digitorum longus or gastrocnemius, both fast-contracting muscles with low oxidative-enzyme activity. Streptozotocin-induced diabetes reduced muscle weights, but did not alter the level of kallikrein (pg/mg of protein) in skeletal muscle, suggesting that insulin is not a regulator of kallikrein in this tissue. Although the role of kallikrein in skeletal muscle is unknown, its localization and activity in relation to muscle functions and disease can now be studied.
Apparatus for Measuring the Dynamic Solids Settling Rates in DrillingFluids (2006)

Apparatus for Measuring the Dynamic Solids-Settling Rates in Drilling Fluids R. Murphy; R. Murphy Halliburton Search for other works by this author on: This Site Google Scholar D. Jamison; D. Jamison Halliburton Search for other works by this author on: This Site Google Scholar T. Hemphill; T. Hemphill Halliburton Search for other works by this author on: This Site Google Scholar S. Bell; S. Bell ISP Search for other works by this author on: This Site Google Scholar C. Albrecht C. Albrecht Halliburton Search for other works by this author on: This Site Google Scholar Paper presented at the SPE Annual Technical Conference and Exhibition, San Antonio, Texas, USA, September 2006. Paper Number: SPE-103088-MS https://doi.org/10.2118/103088-MS Published: September 24 2006 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Murphy, R., Jamison, D., Hemphill, T., Bell, S., and C. Albrecht. "Apparatus for Measuring the Dynamic Solids-Settling Rates in Drilling Fluids." Paper presented at the SPE Annual Technical Conference and Exhibition, San Antonio, Texas, USA, September 2006. doi: https://doi.org/10.2118/103088-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Annual Technical Conference and Exhibition Search Advanced Search Abstract Barite Sag is a reoccurring problem with many oil-based drilling fluids. Attempts to correlate sag tendencies to various rheological properties commonly used to benchmark drilling fluids have had limited success in prevention and anticipation of sag problems in the field. Herein is presented a new testing apparatus for dynamic and static settling rate (sag) measurements, which has been proven to provide a better understanding of the sag phenomena as well as provide a better means to characterize fluid performance. This apparatus greatly expands the precision of sag measurements over previous techniques and allows testing conditions similar to those experienced downhole. Good correlation has been found between settling rate measurements and performance of drilling fluids in the field. Keywords: drilling fluid property, sample cell, drilling fluids and materials, drilling fluid selection and formulation, Upstream Oil & Gas, dhast, drilling fluid chemistry, drilling fluid formulation, viscosity, settling rate Subjects: Drilling Fluids and Materials, Drilling fluid selection and formulation (chemistry, properties) Copyright 2006, Society of Petroleum Engineers You can access this article if you purchase or spend a download.
Ω-Gate Nanowire P-FET with cSiGe Channel Epitaxied on Strained-SOI Substrates (2016)

We present for the first time the successful fabrication of Ω-gate P-type FETs with epitaxial compressively-strained SiGe (Ge=30%) on tensily-strained SOI substrates. The recess down to the strained-Si etch-stop layer in the source/drain (S/D) areas (after spacer etching) followed by a selective epitaxy of in-situ boron-doped Si 0.7 Ge 0.3 raised S/Ds allowed us to offset the performance loss due to tensile strain in short gate length Si 0.7 Ge 0.3 /sSi NW devices. The hole mobility improvement resulting from the compressive strain and VTH shift between Si 0.7 Ge 0.3 /sSi and Si channel transistors led to an I ON current improvement of +100% at L G =15nm compared to SOI, providing a promising path for performant CMOS integration.
High-Temperature Performance of Silicon Junctionless MOSFETs (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper investigates the temperature dependence of the main electrical parameters of junctionless (JL) silicon nanowire transistors. Direct comparison is made to silicon nanowire (trigate) MOSFETs. Variation of parameters such as threshold voltage and <emphasis emphasistype="smcaps">on</emphasis>– <emphasis emphasistype="smcaps">off</emphasis> current characteristics is analyzed. The JL silicon nanowire FET has a lager variation of threshold voltage with temperature than the standard inversion- and accumulation-mode FETs. Unlike in classical devices, the drain current of JL FETs increases when temperature is increased. </para>
Development of a Cognitive Robotic System for Simple Surgical Tasks (2015)

The introduction of robotic surgery within the operating rooms has significantly improved the quality of many surgical procedures. Recently, the research on medical robotic systems focused on increasing the level of autonomy in order to give them the possibility to carry out simple surgical actions autonomously. This paper reports on the development of technologies for introducing automation within the surgical workflow. The results have been obtained during the ongoing FP7 European funded project Intelligent Surgical Robotics (I-SUR). The main goal of the project is to demonstrate that autonomous robotic surgical systems can carry out simple surgical tasks effectively and without major intervention by surgeons. To fulfil this goal, we have developed innovative solutions (both in terms of technologies and algorithms) for the following aspects: fabrication of soft organ models starting from CT images, surgical planning and execution of movement of robot arms in contact with a deformable environment, designing a surgical interface minimizing the cognitive load of the surgeon supervising the actions, intra-operative sensing and reasoning to detect normal transitions and unexpected events. All these technologies have been integrated using a component-based software architecture to control a novel robot designed to perform the surgical actions under study. In this work we provide an overview of our system and report on preliminary results of the automatic execution of needle insertion for the cryoablation of kidney tumours.