gebhart/patrepeval huggingface dataset:
888 Synergistic efficacy of the BRM/BRG1 ATPase inhibitor, FHD-286, and anti-PD-1 antibody in mouse syngeneic tumor models (2022)

<h3>Background</h3> The BAF family of chromatin remodeling complexes are critical regulators of chromatin accessibility and gene expression, and BRM and BRG1 (also known as SMARCA2 and SMARCA4), the catalytic subunits of BAF, provide the enzymatic activity required for chromatin remodeling activity. We have previously identified and characterized a series of novel dual inhibitors of the BRM/BRG1 ATPases, and FHD-286, a potent and selective BRM/BRG1 inhibitor, is currently under clinical investigation for the treatment of metastatic uveal melanoma and advanced hematological malignancies (NCT04879017 and NCT04891757). BAF chromatin remodeling complex activities are implicated in many immunologic responses, and previous studies have shown the involvement of PBAF in the regulation of antitumor immunity.<sup>1</sup> <h3>Methods</h3> Given the recent reports correlating SMARCA4 deficiency and ICI response,<sup>2</sup> we explored the combination of BRM/BRG1 ATPase inhibition and anti-PD-1 antibody in syngeneic mouse models from various lineages and with different sensitivities to checkpoint inhibition. <h3>Results</h3> The combination of FHD-286 and anti-PD-1 antibody provided synergistic efficacy and survival benefit compared to anti-PD-1 alone in A20, CT26, and the immunologically barren B16F10 melanoma model. FHD-286 increased MHCI expression on B16F10 cells, and increases in IFNγ and Th1-type chemokine CXCL10 levels were observed in immunocompetent mice following treatment, suggesting that combinatorial activity may result from effects on both the tumor and the immune system. <h3>Conclusions</h3> FHD-286 has the potential to sensitize tumor to immune-checkpoint inhibition and represents a novel combination approach for cancer immunotherapy. <h3>References</h3> Pan D, <i>et al</i>. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. <i>Science</i>. 2018; <b>359</b>:770–775. Zhou M, <i>et al</i>. Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers. <i>Oncogenesis</i>. 2021; <b>10</b>:3.
Motion planning on a graph (2002)

We are given a connected, undirected graph G on n vertices. There is a mobile robot on one of the vertices; this vertex is labeled s. Each of several other vertices contains a single movable obstacle. The robot and the obstacles may only reside at vertices, although they may be moved across edges. A vertex may never contain more than one object (robot/obstacle). In one step, we may move either the robot or one of the obstacles from its current position /spl upsi/ to a vacant vertex adjacent to v. Our goal is to move the robot to a designated vertex t using the smallest number of steps possible. The problem is a simple abstraction of a robot motion planning problem, with the geometry replaced by the adjacencies in the graph. We point out its connections to robot motion planning. We study its complexity, giving exact and approximate algorithms for several cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
High Performance Poly-Si Thin Film Transistors Fabricated by a Simple Crystallization Method Using Ni-Silicide Seeds (2011)

The major problem of metal-induced crystallized (MIC) polycrystalline Si (poly-Si) thin- film transistors (TFTs) is metal contamination, from Ni and NiSi2. Many attempts have been made to address this problem, however, they all involve complicated processes. In this study, we investigate a new crystallization method, that is, seed-induced crystallization, using Ni silicide seed. There are no additional mask processes, deposition and/or etching processes. The poly-Si thin films crystallized by SIC are characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Auger electron spectroscopy (AES), atomic force microscopy (AFM), micro-Raman scattering spectroscopy and the electrical properties are obtained from ID-VG transfer curve measurements. The results show that, lower Ni contamination, smoother surface and larger grain size are achieved in the SIC produced poly-Si thin films compared to those of the MIC poly-Si thin films. The p-channel SIC poly-Si TFTs, show a mobility of 62.08 cm2/V·s, minimum leakage current of 1.17 × 10−10 A at VD = 10 V, subthreshold slope of 0.7 V/dec and maximum on/off ratio of 1.7 × 106, all of which lead to a high-performance device which exceeds conventional MIC poly-Si TFTs.
Onto-Tools: new additions and improvements in 2006 (2007)

Onto-Tools is a freely available web-accessible software suite, composed of an annotation database and nine complementary data-mining tools. This article describes a new tool, Onto-Express-to-go (OE2GO), as well as some new features implemented in Pathway-Express and Onto-Miner over the past year. Pathway-Express (PE) has been enhanced to identify significantly perturbed pathways in a given condition using the differentially expressed genes in the input. OE2GO is a tool for functional profiling using custom annotations. The development of this tool was aimed at the researchers working with organisms for which annotations are not yet available in the public domain. OE2GO allows researchers to use either annotation data from the Onto-Tools database, or their own custom annotations. By removing the necessity to use any specific database, OE2GO makes the functional profiling available for all organisms, with annotations using any ontology. The Onto-Tools are freely available at http://vortex.cs.wayne.edu/projects.htm.
Silicon MESFET circuit performance for VLSI (1979)

Sub-femto Joule silicon MESFET ring oscillator data, which compare favorably with GaAs MESFET results in the literature, will be reported. Measurements on an output amplifier and on a divide-by-two circuit will also be discussed.
Dedicated architecture for topological operators for grayscale image processing (2003)

In this paper we present the hardware implementation of image segmentation chain based on topological operators on a mixed FPGA/DSP architecture. These operators can segment a bi-class image into regions. This original method is based on some low-level operators, which do not need parameters. This is more interesting in architecture viewpoint, due to its simplicity and the fact that these low-level operators are used somehow in different phases of algorithm, hence an important reduction of used FPGA surface. Beside, the result of the segmentaion consists of closed and thin contours. This method is based on four basic operators which modify the topology of the image in order to segment it. The first operator of the image simplifies the topology of the image while preserving its gray level informations. A real image once simplified is full of irregular regions or points, due the noise or the texture of the regions. The second and third operators selectively eliminate respectively the irregular points and irregular regions. The fourth operator is to reconstruct the image. In this paper we present the implementation of these four operators on PCI architecture based on a FPGA circuit and a DSP processor.
372 Safety and activity of the anti-mesothelin antibody–drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer (2020)

<h3>Introduction</h3> Treatment options for platinum-resistant ovarian cancer (PROC) remain a high medical need. Mesothelin is highly expressed in PROC. Anetumab ravtansine (ARv) is an antibody–drug conjugate that selectively targets mesothelin, consisting of a fully human anti-mesothelin monoclonal antibody conjugated to the cytotoxic maytansinoid tubulin inhibitor DM4. <h3>Methods</h3> This phase Ib, open-label, dose-escalation (modified 3+3 design, n=9) and expansion study (n=56) evaluated the safety/tolerability and clinical activity of ARv and pegylated liposomal doxorubicin (PLD, 30 mg/m² Q3W) in PROC. Mesothelin expression was assessed by central immunohistochemistry. Adverse events, tumor response (RECIST v1.1), and progression-free survival (PFS) were determined. Biomarker samples were assessed by ELISA, next-generation sequencing, and expression profiling. <h3>Results</h3> ARv/PLD combination was safe and tolerated. No DLT was observed. MTD of ARv was 6.5 mg/kg Q3W. The most common ARv-related adverse events were nausea (38.5%), decreased appetite (30.8%), corneal disorder (29.2%), fatigue (29.2%), diarrhea (24.6%), and AST increase (21.5%). In all measurable or evaluable patients (n=65), objective response rate (ORR) was 28% (95% CI 16.0–38.5%), including one complete and 17 partial responses with a median PFS of 5.1 months. In an exploratory subset of patients (n=19) who received ≤3 prior lines of therapy with high mesothelin expression, the ORR was 42% with a median duration of response of 36 weeks. Median PFS was 8.5 months. <h3>Conclusions/Implications</h3> These results established the RP2D, schedule, and mesothelin-positive target population of the ARv/PLD combination for the phase III study in PROC. Molecular profiling and correlation with observed clinical activity will be presented.
Additive Manufacturing of Transparent Ceramic Laser Gain Media - Rods, Thin Disks, and Planar Waveguides (2020)

Spatially distinct and graded doping profiles may be formed in YAG transparent ceramic laser gain media via additive manufacturing. Near-uniform refractive index may be obtained with co-doping of the undoped region with a compensating ion.
Edge states and edge conditions for electromagnetic field in nanophotonics (2015)

Concept of edge polarizability produced by support of the edge quantum states is demonstrated by the example of graphene nanoribbon with zigzag edge configuration. This concept allows to formulate physically correct edge conditions for electromagnetic field in nanostructures instead of ordinary Meixner conditions in classical electrodynamics.
Synthetic Dioxygen-carrying Hemoprotein. Human Serum Albumin Including Iron(II) Complex of Protoporphyrin IX with an Axially Coordinated Histidylglycyl-propionate (2003)

Abstract Human serum albumin incorporating the iron(II) complex of protoporphyrin IX having an axially coordinated histidylglycyl-propionate formed a dioxygen-adduct complex in aqueous media (pH 7.3). The O2-binding affinity (P1/2) was 0.1 Torr at 25 °C.
A read-out strategy for high-resolution large-area SiPM-based modular gamma-ray cameras (2022)

Ongoing developments in the field of molecular imaging have increased the need for gamma-ray detectors with better spatial resolution, while maintaining a large detection area. One approach to improve spatial resolution is to utilize smaller light sensors for finer sampling of scintillation light distribution. However, the number of required sensors per camera must increase significantly, which in turn increases the complexity of the imaging system. Examples of challenges that arise are the analog-to-digital conversion of large numbers of channels, and a bottleneck effect that results from transferring large amounts of raw list-mode data to an acquisition computer. Here we present the design of a read-out electronics system that addresses these challenges. The read-out system, which is designed for a 10” × 10” SiPM-based scintillation gamma-ray camera, can process up to 162 light-sensor signals per event. This is achieved by implementing 1-bit and non-uniform 2-bit sigma-delta modulation analogto-digital conversion, and an on-board processing system with a large number of input/output user pins and relatively high processing power. The processor is a system-on-a-module that also has SDRAM, which allows us to buffer raw list-mode data on board. The bottleneck effect is avoided by buffering event data on the camera module, and only transferring it when the main acquisition computer requests it. This design can be adapted for other crystal/sensor configurations, and can be scaled for a different number of channels.
MIRON: MIPv6 route optimization for NEMO (2004)

Network Mobility (NEMO) Basic Support Protocol enables mobile networks to change their point of attaehment to the Internet, while preserving estahlished sessions of the nodes within the mobile network. NEMO basie solution is an extension of Mobile 1Pv6 and it is based on tunnelling, whieh leads to sUboptimal routing, packet overhead and latency, especially when nesting (i.e. a mobile network that contains other mobile networks within) is involved. In this article we present a route optimisation solution for mobile networks based on Mobile 1Pv6. The goal is to use the route optimisation support for Mohile 1Pv6 available in the Correspondent Nodes to provide route optimisation for mobile networks. The solution also supports nested mobile networks without requiring additional tunnelling, thus reducing packet overhead and lateney with regard to Network Mobility basil:: solution.
Nondestructive Ion Trap Mass Analysis at High Pressure (2010)

A method for performing nondestructive ion trap mass analysis at high pressures (>1 mTorr) has been developed using image current measurement with constant dipolar excitation. Instead of monitoring the ion secular motion, a harmonic of the ion motion was used for narrow band image current measurement followed by Fourier Transform. The capability of this technique has been demonstrated with mass analysis using a single measurement at pressures of 10 mTorr or higher. Methods for mixture analysis and tandem mass spectrometry have also been developed for nondestructive mass analysis.
Surface affinity role in graphoepitaxy of lamellar block copolymers (2016)

Overcoming the optical limitations of 193nm immersion lithography can be achieved using Directed Self Assembly (DSA) of block-copolymers (BCPs) as a low-cost and versatile complementary technique. The goal of this paper is to investigate the potential of DSA to address line and space (L/S) high resolution patterning by performing the density multiplication of lines with the graphoepitaxy approach. As surface affinity is a key parameter in self-assembly, three variations, or "flavors", of DSA template affinity are investigated regarding several success criteria such as morphology control or defectivity. More precisely, both the methodology to register DSA defects and the impact of process parameters on defectivity are detailed. Using the 300mm pilot line available in LETI and Arkema’s advanced materials, we investigate process optimization of DSA line/space patterning of a 38nm period lamellar PS-b-PMMA BCP (L38). For this study, our integration scheme, depicted in figure 2-1, is based on BCP self-assembly inside organic hard mask guiding patterns obtained using 193i nm lithography. Defect analysis coupled with the fine tuning of process parameters (annealing, brush material) provided the optimum conditions for the L38 self-assembly. Using such conditions, DSA using the three affinity flavors is investigated by means of SEM top-view and cross-section review. Lithographic performances of one selected flavor are then evaluated with the comparison of Process Windows (PWs) function of either commensurability, morphology or LWR. This work is a first step in finding the best process for an industrial graphoepitaxy approach.
Application of reversible biotinylated label for directed immobilization of synthetic peptides and proteins: isolation of ligates from crude cell lysates (1997)

Chaperonin 10 protein from Rattus norvegicus (Rat cpn10) has been reported to bind chaperonin 60 from Escherichia coli (GroEL) in an ATP-dependent manner. Chemically synthesized Rat cpn10 was immobilized in a defined orientation to agarose-bound monomeric avidin using a reversible biotinylated affinity label (1), attached to the Nα-terminal residue. The resulting affinity chromatographic matrix was then used to isolate binding proteins from a crude cell lysate. Following affinity separation the bound ligand and ligate was released by treatment with organic base. Rat cpn10 was prepared using a highly effective synthetic protocol involving HBTU/HOBt activation and capping with N-(2-chlorobenzyloxycarbonyloxy) succinimide to terminate unreacted amino groups. The biotinylated Fmoc-based molecule (1) was introduced specifically onto the Nα-terminal amino acid as the succinimidyl carbonate, before final cleavage and deprotection of side-chain protecting groups using a low-TFMSA/high-HF procedure. Crude biotinylated Rat cpn10 (Rat cpn10+1) was immobilized on monomeric avidin with a binding efficiency of approximately 75% and unlabelled truncated/capped impurities eluted off the column with buffer. The biotinylated Rat cpn10–avidin affinity matrix was then used to isolate GroEL from a crude cell lysate. The identity of the purified protein was confirmed by SDS–PAGE and binding to a specific anti-GroEL monoclonal antibody (MoAb). These results extend the applicability of the biotinylated label (1), providing a reversible non-covalent anchor for immobilization of peptide and protein ligands, thus simplifying isolation of ligates and enabling recovery of synthetic material under mild conditions. © 1997 European Peptide Society and John Wiley & Sons, Ltd.
In a model cytosine:guanine base pair, one amino group rotates and the other does not (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn a model cytosine:guanine base pair, one amino group rotates and the other does notLoren Dean Williams, Nidhi Gupta Williams, and Barbara Ramsay ShawCite this: J. Am. Chem. Soc. 1990, 112, 2, 829–833Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00158a050https://doi.org/10.1021/ja00158a050research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Ski Protein Family Is Required for MeCP2-mediated Transcriptional Repression (2001)

DNA methylation is essential for development in the mouse and plays an important role in inactivation of the X chromosome and genomic imprinting. MeCP2 is the founder member of a family of methyl-CpG-binding proteins. MeCP2 directly binds to the co-repressor mSin3, which interacts with class I histone deacetylase, recruiting them to methyl-CpG regions to suppress transcription. Here, we report that MeCP2 directly binds to two co-repressors, c-Ski and N-CoR, in addition to mSin3A, and that the c-Ski, which is encoded by the c-ski proto-onocogene, is required for MeCP2-mediated transcriptional repression. The two regions of c-Ski, including the C-terminal coiled-coil region, interact with the transcriptional repression domain in the center of the MeCP2 molecule. The immunostaining signals for c-Ski and MeCP2 overlap in the nuclear heterochromatin region, suggesting the co-localization of the two proteins. The degree of transcriptional repression mediated by a Gal4-MeCP2 fusion protein was abrogated by overexpression of the putative dominant negative form of c-Ski. Furthermore, injection of antibodies against c-Ski and Sno almost completely abolished the transcriptional repression mediated by the Gal4-MeCP2 fusion protein. These results suggest that the ski gene family is involved in methyl CpG-mediated transcriptional repression.
Interferometric method for concurrent measurement of thermo-optic and thermal expansion coefficients (1991)

A Fabry-Perot-type interferometer is described that permits the concurrent measurement of the coefficient of thermal expansion (alpha) and the thermooptic coefficient (dn/dT) of transparent materials. Measurements of the a and the dn/dT of vitreous silica and a heavy-metal fluoride glass show that the technique is accurate, reproducible, and easily performed. In addition, the technique is used to show that the dn/dT of heavy-metal fluoride glasses is negative and temperature dependent. The magnitude of dn/dT is found to increase with increasing temperature.
Supplementary Table S2 from Direct Detection and Quantification of Neoantigens (2023)

&lt;p&gt;MANA-SRM parameters for peptide targets.&lt;/p&gt;
Sputtered Ni-base Superalloys for Microscale Devices (2012)

Metallic thin films, micro-devices and microelectromechanical systems (MEMS) suffer from a lack of thermal stability and poor mechanical properties at high temperatures. By contrast, cast and forged Ni-base superalloys have excellent high temperature properties, but shaping and processing routes for superalloy micro devices have not been developed. Here free-standing nanocrystalline foils of the Ni-based superalloy, Haynes 718, were produced by magnetron sputtering and mechanical removal from Si substrates. Precipitation studies revealed unique transformation paths compared to the bulk alloy. Heat treated foils possess yield stresses of 400MPa at 700C. These results suggest that sputtered superalloys could extend the operating ranges of micro-devices. Furthermore, nanocrystalline alloys obtained through vapor phase processing provide thermal processing paths unattainable from the melt.
Coal hydrogenation process employing an expanded particulate solids bed (1971)

We report the development and initial evaluation of a device for robotic assisted upper extremity repetitive therapy (RUPERT). Intense repetitive physical therapies provided by individualized interaction between the patient and a rehabilitation specialist to overcome upper extremity impairment after stroke are beneficial, however, they are expensive and difficult to evaluate quantitatively and objectively. The need is urgent and growing for a low cost, safe and easy to use robotic device to assist the patient and the therapist to fully achieve the potential benefit of task-based repetitive physical therapies. We designed a pneumatic muscle (PM) driven therapeutic device, the RUPERT, that is wearable and provides assistive forces required to move the arm during performance of several critical tasks of daily living. The robot has four degrees of freedom at shoulder, elbow and wrist. The sensors feedback position and force information for quantitative evaluation of task performance. It has the potential of providing a take-home method of supplementing therapy. The device can also provide real-time, objective assessment of functional improvement of therapy.