gebhart/patrepeval huggingface dataset:
The association of peripheral monocyte derived interleukin 1beta (IL-1beta), IL-1 receptor antagonist, and tumor necrosis factor-alpha with osteoarthritis in the elderly. (1998)

We found no consistent association of PBMC cytokine production and radiographic OA. However, women with the highest production of IL-1beta and IL-1Ra had respectively higher rates of knee OA and lower rates of hand OA than expected.
Umbralisib monotherapy demonstrates efficacy and safety in patients with relapsed/refractory marginal zone lymphoma: A multicenter, open label, registration directed phase II study. (2019)

7506 Background: Rituximab (RTX) alone or with chemo has substantially improved outcomes for patients (pts) with marginal zone lymphoma (MZL), but relapse is common and not all pts are candidates for or respond to current salvage therapies. Umbralisib is a novel, next-gen PI3Kδ inhibitor with unique inhibition of casein kinase-1ε (CK1ε) and a differentiated tolerability profile compared to earlier PI3Kδ inhibitors (Burris et al, 2018). This registration-directed study evaluates the efficacy and safety of umbralisib in pts with rel/ref (R/R) MZL. Methods: Pts had histologically confirmed MZL, ECOG PS ≤2, and ≥1 prior therapy including ≥1 anti-CD20 mAb-containing regimen. Pts received umbralisib 800 mg orally once daily until PD or unacceptable toxicity. The primary endpoint was overall response (ORR) as assessed by independent review (IRC) per 2007 IWG criteria. ORR by investigator assessment is reported here, and ORR by IRC is forthcoming. Secondary endpoints included duration of response (DOR), PFS, and safety. Results: 69 pts were enrolled; we report on the first 38 who are eligible for at least 6 months (mos) of follow-up as of the data cutoff. Among the 38 pts: extranodal (n = 23), nodal (n = 8), and splenic (n = 7). Median age was 67 years (range, 34-81). Median # of prior systemic therapies was 2 (range, 1-5). Seven pts (18%) had monotherapy RTX only, and 26 (68%) had at least one anti-CD20 mAb-containing chemoimmunotherapy. Median follow-up was 9.6 mos. ORR was 55% (4 CRs and 17 PRs). Eleven pts (29%) had stable disease (SD) of which 6 of these SD pts remain on study ranging from 7-12+ mos. The clinical benefit rate (CR+PR+SD) was 84%, and 91% of pts with at least 1 post-baseline assessment experienced tumor reductions. Median time to initial response was 2.7 mos, while median DOR was not reached (95% CI: 8.4-NR). The 12-month PFS was 71%. The most common all causality (≥20%) adverse events (AE) of any grade included: diarrhea (45%), nausea (29%), fatigue (26%), headache (26%), cough (24%), and decreased appetite (21%). The most common Grade 3/4 events were neutropenia (8%), febrile neutropenia (5%), and diarrhea (5%). As of the cutoff date 58% continue treatment. Conclusions: PI3Kδ inhibition with single-agent umbralisib is active and well tolerated in pts with R/R MZL, achieving durable responses with chemotherapy-free therapy. Clinical trial information: NCT02793583.
Long-range broadband wireless system for maritime communications in the 3.5 GHz band (2021)

Considering the increasing demands of wireless data transfer fuelled by the introduction of 4G and 5G, the maritime transport industry is looking for new wireless technologies able to provide a sufficient quality of service on board based on extended terrestrial wireless coverage. However due to the nature of the propagation channel and the large cell size, the design of a maritime wireless network with terrestrial base station is challenging. We present in this paper the deployment of a maritime network in the 3.5 GHz TDD band complementary to a satellite network to deliver high-speed data rate with low latency at low cost. The network architecture is first described and performance of the proposed 5G NR-like system are assessed under field trials. We demonstrate that the coverage the Channel from the French and UK coasts is possible with appropriate base station location and dedicated antenna strategies to deliver 80+ Mbps.
Rapid Identification of Coumarins from Micromelum falcatum by UPLC-HRMS/MS and Targeted Isolation of Three New Derivatives (2014)

Micromelum falcatum, a medicinal plant of the Rutaceae family, has been used in the Traditional Chinese Medicine (TCM) mainly against colds and rheumatoid arthritis. Despite its traditional use the association of its constituents with possible anti-inflammatory activity has not been explored. During this study, a rapid UPLC-ESI(+)-HRMS method was developed for the profiling of M. falcatum leave extracts and the targeted isolation of coumarin constituents. Based on chromatographic, spectroscopic and spectrometric features several 7-oxygenated coumarin derivatives were detected. After targeted isolation, eight coumarins, among them three new natural products, namely microfalcrin, microcoumaririn and micromelosidester, were purified using semi-preparative HPLC and unambiguously identified by 1 and 2D NMR. Furthermore, important spectrometric characteristics were revealed based on the HRMS and HRMS/MS spectra of the isolated 7-oxygenated coumarins facilitating their identification in complex mixtures. Finally, the anti-inflammatory properties of the extracts and representative compounds were evaluated by measuring the inhibition of the pro-inflammatory mediator NF-κB induction and nitric oxide (NO) production.
Islam and Religious Hate Crime (2022)

Our previous work considered the ability to ‘abuse, ridicule, threaten, defame, mock and insult the religious beliefs, icons, prophets, practices and esteemed figures of believers’. This chapter will revisit such issues, but the foci are the legal definitions of ‘religious hate crime,’ and arguments concerning the potential dangers of effectively reinstating ‘blasphemy’ for one specific religion. Currently, as with all ‘hate crimes offences,’ a base offence must be committed, motivated by, or demonstrate hostility towards, a protected religion, or indeed, atheism. Equally, intention to incite religious hatred is criminalised. This chapter analyses ‘privileging’ one religious belief over others, for example, Islam. Analysis considers support for, but also the implications for the operation of ‘hate crime,’ prosecution, and practices deemed ‘religious’ in nature, by some, but potentially criminal by others. The methodology utilises literary and legal analysis. The foci are England and Wales, as illustrative of the concerns raised by religion, crime, and control, but these are relevant to democracies worldwide.
Experiences with Double- and Single-Ended Fault Location in Compensated Network Applaying Travelling Wave Technology (2019)

This paper presents the experiences with travelling wave technology for fault location in compensated and isolated power grids [1]. Moreover, the installed pilot monitoring system as well as the background of the fault location with travelling waves is presented in detail. Some typical cases of successful fault locating and the potential of collecting additional information from the captured records is discussed. This is the first time the travelling wave technology is applied successfully for the localization of short-term single phase-to-earth faults in a compensated network.
Lead-free epitaxial ferroelectric material integration on semiconducting (100) Nb-doped SrTiO3 for low-power non-volatile memory and efficient ultraviolet ray detection (2015)

We report lead-free ferroelectric based resistive switching non-volatile memory (NVM) devices with epitaxial (1-x)BaTiO3-xBiFeO3 (x = 0.725) (BT-BFO) film integrated on semiconducting (100) Nb (0.7%) doped SrTiO3 (Nb:STO) substrates. The piezoelectric force microscopy (PFM) measurement at room temperature demonstrated ferroelectricity in the BT-BFO thin film. PFM results also reveal the repeatable polarization inversion by poling, manifesting its potential for read-write operation in NVM devices. The electroforming-free and ferroelectric polarization coupled electrical behaviour demonstrated excellent resistive switching with high retention time, cyclic endurance, and low set/reset voltages. X-ray photoelectron spectroscopy was utilized to determine the band alignment at the BT-BFO and Nb:STO heterojunction, and it exhibited staggered band alignment. This heterojunction is found to behave as an efficient ultraviolet photo-detector with low rise and fall time. The architecture also demonstrates half-wave rectification under low and high input signal frequencies, where the output distortion is minimal. The results provide avenue for an electrical switch that can regulate the pixels in low or high frequency images. Combined this work paves the pathway towards designing future generation low-power ferroelectric based microelectronic devices by merging both electrical and photovoltaic properties of BT-BFO materials.
<title>Multicriteria optimization approach for optical pattern recognition with nonoverlapping target and scene noise</title> (1998)

The design of filters for pattern recognition that have optimal trade-offs among the criteria of noise robustness, sharpness of the correlation peak, and Horner efficiency when input scene noise is spatially disjoint (nonoverlapping) with the target are presented. Computer simulation is made to illustrate filter performances for optical pattern recognition.
Benefit of neural network for the optimization of defect - Detection on composite material using ultrasonic non destructive testing (2021)

International audience
Integrated vertical parallel-plate capacitive humidity sensor (2011)

A high sensitivity capacitive chemical vapor sensing topology, a vertical parallel-plate sensor, was successfully integrated with CMOS testing electronics. The sensor was fabricated by etching a sacrificial aluminum layer in the CMOS stack and filling the resulting cavity with polyimide. The measured humidity response is a 0.31% change in capacitance per percent relative humidity. The temperature sensitivity of the sensor, an important specification for a sensor exposed to a variety of environmental conditions, is 0.19% °C−1. The rising and falling response time constants for a change in relative humidity are 70 and 85 s, respectively. The minimum detectable signal is 0.06 fF, corresponding to a limit of detection of 0.0023% relative humidity.
Chortle-crf: Fast technology mapping for lookup table-based FPGAs (1991)

A new technology mapping algorithm for lookup tablebased Field Programmable Gate Arrays (FPGA) is presented. The major innovation is a method for choosing gate-level decompositions based on bin packing. This approach is up to 28 times faster than a previous exhaustive approach. The algorithm also exploits reconvergent paths and replication of logic at fanout nodes to reduce the number of lookup tables in the circuit. The new algorithm is implemented in the Chortle-crf program. In an experimental comparison Chortle-crf requires 14 YO fewer lookup tables than Chortle [Fran90] and 10 ~o fewer lookup tables than mis-pga [Murg90a] to implement a set of benchmark networks. Chortle-crf can also implement a network as a circuit of Xilinx 3000 series Configurable Logic Blocks (CLBS). To implement the benchmark networks as circuits of CLBS Chortle-crf requires 12 70 fewer CLBS than mis-pga and 22 % fewer CLBS than XNFOPT [Xili89]. In these experiments Chortle-crf waa an average of 68 times faster than mis-pga and 30 times faster than XNFOPT. 1
Integrating the Kuramoto-Sivashinsky equation in polar coordinates: Application of the distributed approximating functional approach (1999)

An algorithm is presented to integrate nonlinear partial differential equations, which is particularly useful when accurate estimation of spatial derivatives is required. It is based on an analytic approximation method, referred to as distributed approximating functionals (DAF's), which can be used to estimate a function and a finite number of derivatives with a specified accuracy. As an application, the Kuramoto-Sivashinsky (KS) equation is integrated in polar coordinates. Its integration requires accurate estimation of spatial derivatives, particularly close to the origin. Several stationary and nonstationary solutions of the KS equation are presented, and compared with analogous states observed in the combustion front of a circular burner. A two-ring, nonuniform counter-rotating state has been obtained in a KS model simulation of such a burner.
Direct integration of battery energy storage systems in distributed power generation (2011)

In this paper, a wind energy conversion system interfacedto the grid using a dual inverter is proposed. One of the twoinverters in the dual inverter is connected to the rectified outputof the wind generator while the other is directly connected to abattery energy storage system (BESS). This approach eliminatesthe need for an additional dcdc converter and thus reduces powerlosses, cost, and complexity. The main issue with this scheme isuncorrelated dynamic changes in dc-link voltages that results inunevenly distributed space vectors. A detailed analysis on the effectsof these variations is presented in this paper. Furthermore,a modified modulation technique is proposed to produce undistortedcurrents even in the presence of unevenly distributed anddynamically changing space vectors. An analysis on the batterycharging/discharging process and maximum power point trackingof the wind turbine generator is also presented. Simulationand experimental results are presented to verify the efficacy of theproposed modulation technique and battery charging/dischargingprocess.
FLUIDIZED BED POLYMER PARTICLE ALD TM PROCESS FOR PRODUCING HDPE/ALUMINA NANOCOMPOSITES (2007)

Micron-sized High Density Polyethylene (HDPE) particles were coated with ultrathin alumina (Al2O3) films in a Fluidized Bed Reactor (FBR) by Atomic Layer Deposition (ALD) at 77 oC. Fluidization of HDPE particles were achieved at reduced pressure with the assistance of stirring or vibration. Al2O3 films on the HDPE particles were confirmed by different methods. These particles were extruded conventionally with the ceramic shells mixing intimately in the polymer matrix. The successful dispersion of the crushed Al2O3 shells in the polymer matrix following extrusion was confirmed.
Thermo-Optical Absorption Detection in 25-μm-i.d. Capillaries: Capillary Electrophoresis of Dansyl-Amino Acids Mixtures (1991)

An intensity-modulated 257-nm pump laser beam is used to induce refractive index changes inside of a capillary tube employed as an on-line detection system for capillary electrophoresis. These refractive index changes inside the capillary are monitored by demodulating the periodic lateral shifts of the interference fringes, generated by a probe laser beam oscillating at 633 nm, with a phase-sensitive amplifier. The use of capillaries with an internal diameter of 25 μm results in a twofold benefit in electrophoretic separations in conjunction with thermo-optical detection. The pumped heat is efficiently quenched at the capillary wall, and high electrical fields can be applied along the separation tube. The combination of both effects leads to highly efficient separations and fast modulations of the pump source. This is demonstrated by the separation of a test mixture of three dansylated amino acids in less than two minutes. Only 350-pg amounts of total sample are injected onto the column, and the detection volume is less than 10 pL.
Diaryliodonium salts as hydrosilylation initiators for the surface functionalization of silicon nanomaterials and their collaborative effect as ring opening polymerization initiators (2017)

Diaryliodonium salts were found to initiate hydrosilylation reactions on the surface of silicon nanosheets as well as silicon nanocrystals of different sizes. A variety of different functional substrates can be used to stabilize the surface of the photoluminescent materials. Additionally, the combination of hydride terminated silicon nanomaterials with diaryliodonium salts was found to initiate cationic ring opening polymerization, demonstrating the potential of silicon based nanomaterials as coinitiators and enabling a mild, straightforward reaction method.
Interfacial Charge Recombination Between e−−TiO2 and the I−/I3− Electrolyte in Ruthenium Heteroleptic Complexes: Dye Molecular Structure−Open Circuit Voltage Relationship (2008)

A series of heteroleptic ruthenium(II) polypyridyl complexes containing phenanthroline ligands have been designed, synthesized, and characterized. The spectroscopic and electrochemical properties of the complexes have been studied in solution and adsorbed onto semiconductor nanocrystalline metal oxide particles. The results show that for two of the ruthenium complexes, bearing electron-donating (-NH2) or electron-withdrawing (-NO2) groups, the presence of the redox-active I(-)/I3(-) electrolyte produces important changes in the interfacial charge transfer processes that limit the device performance. For example, those dyes enhanced the electron recombination reaction between the photoinjected electrons at TiO2 and the oxidized redox electrolyte. In an effort to understand the details of such striking observations, we have monitored the charge transfer reactions taking place at the different interfaces of the devices using time-resolved single photon counting, laser transient spectroscopy, and light-induced photovoltage measurements.
Querying and re-using workflows with VsTrails (2008)

We show how work flow systems can be augmented to leverage provenance information to enhance usability. In particular, we will demonstrate new mechanisms and intuitive user interfaces designed to allow users to query work flows by example and to refine work flows by analogies. These techniques are implemented in VisTrails, an open-source provenance-enabled scientific work flow system that can be combined with a wide range of tools, libraries, and visualization systems. We will show di erent scenarios where these techniques can be used to simplify the notoriously hard tasks of creating and refining work flows.
Study of alternative back contacts for thin film Cu2ZnSnSe4-based solar cells (2014)

Cu2ZnSnSe4 thin film solar cells are usually fabricated on a soda lime glass substrate with a molybdenum (Mo) back contact. It is suspected that degradation in electrical performance occurs due to the formation of a barrier between the absorber and Mo back contact. To overcome such degradation, Titanium Nitride (TiN), Titanium Tungsten (TiW), Chromium (Cr), Titanium (Ti) and Aluminum (Al) deposited on Mo-coated glass substrates are investigated as alternative back contact materials. Physical and electrical characterization as well as photoluminescence measurements are performed. Compositional analysis of the absorber layer on the metallized substrates identifies Mo, TiN and TiW as being the most inert during the formation of Cu2ZnSnSe4. On the other hand, Ti and Cr reacted with Se during selenization, thereby affecting the growth of the absorber, leading to low conversion efficiency. For Al, the absorber layer was etched after the standard potassium cyanide etch, hence, cannot be used as a back contact. The best device efficiencies obtained are 8.8% on TiN, 7.5% on Mo and 5.9% on TiW, respectively. The TiN back contact provides the lowest barrier value of about 15 meV which could be considered as a good ohmic contact.
Critical Heat Flux in a Vertical Annulus under Low Upward Flow and near Atmospheric Pressure (1997)

As future boiling water reactors (BWR), concepts of evolutional ABWR (ABWR-IER) and natural circulation BWR (JSBWR) have been investigated in order to reduce their construction cost and simplify their maintenance and inspection procedures. One of the promised features of the design of the evolutional ABWR is to reduce the number of internal pumps and to remove the Motor Generation (MG) sets. These design changes may induce boiling transition in the fuel rods of reactor core during a pump trip transient due to the more rapid flow coastdown characteristics than these of the present design. In addition, the understanding of critical heat flux (CHF) is one important subject to grasp safety margin during the start-up for the natural circulation BWR and to establish the rational start-up procedure in which thermo-hydraulic instabilities can be suppressed.The present study is to clarify CHF characteristics under low velocity conditions. CHF measurements were conducted in a vertical upward annulus channel composed of an inner heated rod and an outer tube made of glass. CHF data were obtained repeatedly under the condition of stable inlet flow to examine statistically their reproducibility. The flow regime was investigated from flow observation and measurement of differential pressure fluctuation. The CHF data are correlated with the flow regime transition. It was clear from the obtained flow pattern and the CHF data that the CHF behavior could be classified into specified regions by the mass flux and inlet subcooling conditions. A CHF correlation was developed and agreed with other researchers' data within acceptable error.
L'intercommunalité, une variable d'ajustement dans la réforme des collectivités territoriales ? Généalogie d'un projet, stratégie et arbitrages politiques (2012)

Extrait du texte : « Nous avons donc décidé […] de supprimer la taxe professionnelle pour alléger le poids de la fiscalité sur les investissements des entreprises. C’est un choix sur lequel nous ne reviendrons pas. Parce que ce choix, c’est celui de la compétitivité. Alors je sais bien : quand on fait une réforme, celui à qui elle profite est d’une discrétion de bluette, la preuve qu’il est extrêmement content c’est qu’il ne dit rien. Et celui – et c’est normal, j’ai été élu local pendant si longtemps – qui s’inquiète, celui-là on l’entend. Je comprends parfaitement vos inquiétudes. Elles sont doubles : “On sait ce que l’on a, on ne sait pas ce que l’on va avoir” et s’agissant des rapports avec l’État, vous avez été tant de fois échaudés que vous vous dites : “ils vont encore une fois nous rouler dans la farine”. Voilà très exactement ce que pensent les maires. C’est très exactement ce que vous pensez mais en même temps, vous pensez aussi que l’on ne peut pas rester immobiles… J’en viens à la réforme ..."
Nanospheres of a Bisphosphonate Attenuate Intimal Hyperplasia (2006)

The present study explored a novel strategy for attenuation of restenosis after arterial injury by a bisphosphonate encapsulated in polymeric nanoparticles (NP) for transient selective depletion of macrophages. A bisphosphonate (BP), 2-(2-Aminopyrimidino) ethyldiene-1,1-bisphosphonic acid betaine (ISA), was successfully formulated in 400 nm sized polylactide/glycolide-based NP with high yield (69%) and entrapment efficiency (60% w/w). ISA NP, but not blank NP or free ISA, exhibited specific and significant cytotoxic effect on macrophages-like RAW 264 cells, in a dose-dependent manner, with no inhibitory effect on the growth of smooth muscle cells (SMCs). Fluorescent pyrene-labeled NP were shown to be taken up by RAW 264 cells, but not by SMCs. Intravenously (i.v.) administered ISA NP (15 mg/kg, single dose on day-1) resulted in a significant attenuation of neointima to media area ratio (N/M) by 40% and stenosis by 45% 14 days after rat carotid injury, in comparison to animals treated with free ISA, buffer or blank NP. However, the effect was not preserved 30 days post injury, and an insignificant reduction of neointimal formation was observed. Neointimal hyperplasia was also significantly suppressed after subcutaneous (SC) injection of ISA NP (15 mg/kg, single dose on day-1), reducing both N/M and stenosis. Intraperitoneal (i.p.) injection of silica, a known selective toxin for macrophages, (1000 mg/kg), also resulted in a significant inhibition of N/M and stenosis, which further reinforces the cause-effect relationship of macrophage-inactivation and the prevention of neointima formation. Biocompatible and biodegradable NP loaded with ISA characterized by high colloidal stability, reproducible activity, and high drug entrapment warrant further consideration for restenosis therapy, and may be useful in other disease processes involving monocytes/macrophages.