gebhart/patrepeval huggingface dataset:
Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition (2022)

High-resolution spatial and temporal responses of tumor vessels to two agents known to improve vascular perfusion globally reveal spatially heterogeneous changes in vessel structure and function. These dynamic vascular changes should be considered in optimizing the dose and schedule of vascular and stromal normalizing strategies to improve the therapeutic outcome.
Micro-Scale Chiplets Position Control (2019)

We address the problem of position control of micro-chips (chiplets) immersed in a fluid. An electric field, shaped by controlling the voltages of spiral-shaped electrodes, is used to reliably and accurately transport and position chiplets using dielectrophoretic forces. A lumped, capacitive-based (nonlinear) motion model is used to generate an open loop control policy. The spatial dependency of the capacitances is estimated using detailed electrostatic COMSOL simulations. The open loop policy is generated using a one step model predictive control approach. By exploiting the spatial symmetry and periodicity of the open loop control solution, a real-time control scheme is designed by applying simple algebraic operations to a base function defined on a finite domain. The chiplets position is tracked using image processing algorithms. We demonstrate the validity of our approach with an experiment where real-time control is used to move a chiplet for 1000 μm in a controlled manner. The results shown in this paper represent a critical step for the realization of a system that can digitally convert a design directly to the physical placement of micro-chips.
An Approach To Separation Of Duties Validation For Mils Security Configurations (2017)

Separation of duties (SoD) is an important concept aimed to constrain the excessive powers of subjects regarding system assets and control functions. Ensuring the fact that SoD is properly implemented for the particular task may require the individual approach in every given case.<br> This paper proposes an approach to SoD validation conducted by the analysis of the security configuration of MILS-based solution. The security policy based on object capabilities is considered for this purpose. For this security policy two basic issues should be met. The first issue is the enough expressivity of the security policy. It is addressed with demonstration of particular examples of usage scenarios. The second issue regards the conditions under which the security problem remains tractable. Solving this issue in context of specifically defined SoD criteria is at the core of this research.<br> The approach is implemented for the security configurations of Kaspersky Security System.
A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer's Disease (2014)

Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2-3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naïve patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.
Selection of radioimmunoconjugates for the therapy of well-established or micrometastatic colon carcinoma (1997)

In order to optimize radioimmunotherapy (RAIT) as a cancer-treatment modality, it is necessary to select the appropriate radionuclide and antibody carrier. We evaluated the therapeutic potential of a single cycle of Mu-9 anti-CSAp monoclonal antibody (MAb) labeled with 3 different radionuclides, 131I, 90Y and 188Re. Intact antibodies and bivalent fragments with different blood clearance kinetics, normal organ distribution and varying tumor accretion and retention are also evaluated. Efficacy of treatment for large and small tumor burden was assessed in nude mice bearing s.c. GW-39 human colonic-carcinoma xenografts or intrapulmonary micrometastatic GW-39 colonies at the maximal tolerated dose of each agent. The magnitude and duration of myelosuppression associated with each radioantibody was considered by monitoring peripheral blood counts, marrow colony-forming unit activity and hematopoietic tissue weight. Radiation-dose estimates were calculated based on the kinetics of antibody accretion and elimination from tumor and normal tissues, and the results were correlated with tumoricidal activity and dose-limiting toxicity results. These studies, therefore, represent a detailed analysis, in a well-defined experimental tumor system, of several parameters (antibody form, radioisotope, tumor size) influencing the overall outcome of RAIT using equitoxic doses. It was found that myelosuppression is the primary dose-limiting toxicity for all radioantibodies except 90Y-F(ab')2, even though the different agents showed varied organ distribution. In a single-cycle treatment schedule of Mu-9 MAb, the 131I-labeled IgG is the radioimmunoconjugate of choice for the treatment of s.c. and intrapulmonary growth of the GW-39 human colonic-carcinoma xenograft in nude mice.
SAT-038 Physiology of Mice Lacking All Four Adenosine Receptors (2019)

The importance of multiple adenosine receptors (AR) and the role of adenosine signaling in normal physiology, as opposed to danger/damage situations, are unclear. We generated mice (QKO) lacking all four AR, Adora1-/-;Adora2a-/-;Adora2b-/-;Adora3-/-, to enable investigation of the AR-dependence of physiologic processes. The QKO mice bred normally and had similar body temperature regulation as controls, including diurnal variation, fasting-induced torpor, and response to environmental stimuli. Pharmacologic doses of adenosine agonists cause profound hypothermia via each of the four AR. We hypothesized that uptake and phosphorylation of adenosine might also trigger hypothermia by additional mechanisms, such as activation of adenosine monophosphate-activated protein kinase (AMPK). However, adenosine did not cause hypothermia (or bradycardia or hypotension) in QKO mice, indicating that AR-independent, ‘energy depletion’ signals do not cause adenosine-induced hypothermia. AMP-induced hypothermia was attenuated in QKO mice, demonstrating a role for both AR-dependent and AR-independent mechanisms in this process. In contrast, the hypothermias elicited by adenosine kinase inhibition (using A-134974), inosine, and uridine each require AR, as all were abolished in the QKO mice. The proposed mechanism for uridine-induced hypothermia is inhibition of adenosine transport, increasing local extracellular adenosine levels. The physiology of the QKO mice replicates that of the individual knockout mice, without evidence for synergy, suggesting that the actions of the four AR are generally complementary. The relatively mild phenotype of the QKO mice supports the hypothesis that extracellular adenosine has less of a contribution to baseline physiology and is more important as a local signal of stress, damage, and/or danger.
Kratom policy: The challenge of balancing therapeutic potential with public safety (2019)

Kratom (Mitragyna speciosa) is a tree-like plant indigenous to Southeast Asia. Its leaves, and the teas brewed from them have long been used by people in that region to stave off fatigue and to manage pain and opioid withdrawal. Evidence suggests kratom is being increasingly used by people in the United States and Europe for the self-management of opioid withdrawal and treatment of pain. Recent studies have confirmed that kratom and its chemical constituents have potentially useful pharmacological actions. However, there have also been increasing numbers of reports of adverse effects resulting from use of kratom products. In August 2016, the US Drug Enforcement Administration announced plans to classify kratom and its mitragynine constituents as Schedule I Controlled Substances, a move that triggered a massive response from pro-kratom advocates. The debate regarding the risks, and benefits and safety of kratom continues to intensify. Kratom proponents tout kratom as a safer and less addictive alternative to opioids for the management of pain and opioid addiction. The anti-kratom faction argues that kratom, itself, is a dangerous and addictive drug that ought to be banned. Given the widespread use of kratom and the extensive media attention it is receiving, it is important for physicians, scientists and policy makers to be knowledgeable about the subject. The purpose of this commentary is to update readers about recent developments and controversies in this rapidly evolving area. All of the authors are engaged in various aspects of kratom research and it is our intention to provide a fair and balanced overview that can form the basis for informed decisions on kratom policy. Our conclusions from these analyses are: (a) User reports and results of preclinical studies in animals strongly suggest that kratom and its main constituent alkaloid, mitragynine may have useful activity in alleviating pain and managing symptoms of opioid withdrawal, even though well-controlled clinical trials have yet to be done. (b) Even though kratom lacks many of the toxicities of classic opioids, there are legitimate concerns about the safety and lack of quality control of purported "kratom" products that are being sold in the US. (c) The issues regarding the safety and efficacy of kratom and its mitragynine constituent can only be resolved by additional research. Classification of the Mitragyna alkaloids as Schedule I controlled substances would substantially impede this important research on kratom.
Simple and Convenient Approach for Synthesis of Tetrahydroquinoline Derivatives and Studies on Aza-Cope Rearrangement (2011)

Abstract A simple and novel synthesis of 1,2,3,4-tetrahydroquinoline derivatives by polyphosphoric acid–assisted reaction of N-aryl allyl anilines prepared from anilines has been reported. The generality and scope of the approach has been demonstrated by extending it to the synthesis of 1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline (lilolidine) and 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline (julolidine). Further, Lewis acid–mediated aza-Cope rearrangement of various N-aryl allyl anilines has been demonstrated.
Prediction of plasticization in a real biopolymer system (starch) using molecular dynamics simulations (2019)

Virgin biopolymers are often brittle, which means that they need efficient, sustainable, non-toxic plasticizers for most practical applications. Although the mechanical properties of biopolymers plasticized with e.g. sugars have been extensively investigated, the explanation why efficient plasticization normally only occurs above 20 wt% plasticizer is still lacking. In this work, starch/glycerol was used as a model system to show that all-atom molecular dynamics (MD) simulations can be used to capture the transition region at 20–30 wt% plasticizer, where plasticization becomes pronounced. Tensile properties and PVT data (densities and glass transition temperatures) were obtained both from MD simulations and from measurements on real starch/glycerol materials, confirming that MD could capture the experimentally observed transition region. Also, the simulated glycerol diffusivity correlated well with the trends in the mechanical properties. Percolation theory was used to derive a probable explanation of the observed transition. The results indicate that the MD methodology can be used also for other polymer/plasticizer systems and has the potential to be a valuable tool for optimizing the type and amount of plasticizer in a given polymer, as well as being a tool for the design of new efficient plasticizers.
Proceedings of the Seventh ACM International Conference on Underwater Networks and Systems (2012)

networking promises to open exciting new frontiers for scientific, environmental, commercial, safety, and military applications. Indeed, rivers, oceans, and lakes occupy a central place in the world, and impact our daily lives and are themselves impacted by human activities. Networked underwater systems are still in their infancy, and while the vision of an Underwater Wireless Internet may still appear remote, there are great opportunities today for exciting research and development with potentially broad impacts.

Since 2006, WUWNet has been the premiere ACM venue for underwater networking research, featuring strong communications and networking papers. This year, we transitioned WUWNet from being a stand-alone workshop into a conference, with an extended scope and program. The technical program committee is happy to present 21 full papers, six short papers, and 19 extended abstracts presented as posters, featuring top-notch research on topics as diverse as new applications of underwater networking to new physical-layer communication techniques. The total number of papers presented this year is about double compared to previous editions of the conference. The conference attracted interested from throughout the world. This year, about 45% of the paper authors are from North America, 35% from Asia, 10% from Europe, 5% from Oceania and 5% from South America.
The diverse spectrum of sliding clamp interacting proteins (2003)

DNA polymerase sliding clamps are a family of ring-shaped proteins that play essential roles in DNA metabolism. The proteins from the three domains of life, Bacteria, Archaea and Eukarya, as well as those from bacteriophages and viruses, were shown to interact with a large number of cellular factors and to influence their activity. In the last several years a large number of such proteins have been identified and studied. Here the various proteins that have been shown to interact with the sliding clamps of Bacteria, Archaea and Eukarya are summarized.
Ca/sup 2 +/ and glucose uptake in adipocytes: evidence for biological activity of a Ca/sup 2 +/-palmitate complex (1986)

A tightly bound form of Ca/sup 2 +/ in serum, thought to be a Ca/sup 2 +/-fatty acid complex, has been reported to cause accelerated Ca/sup 2 +/ uptake in bone cells. The authors therefore studied the effect of palmitic acid on Ca/sup 2 +/ accumulation and its influence on glucose transport in adipocytes. They assessed /sup 45/Ca/sup 2 +/ and /sup 14/C-D-glucose uptake into rat adipocytes from solutions containing: 4% (w/v) fatty acid-free albumin, 2.5 mM CaCl/sub 2/ (free (Ca/sup 2 +/)=1.30 mM), 140 mM NaCl, 3 mM Na phosphate, 1.4 mM MgSO/sub 4/, 5 mM D-glucose, 5 mM HEPES, pH 7.4 at 37/sup 0/C with and without 4 mM palmitate. Ca/sup 2 +/ was taken up by both rapid (< 30 sec), and slow (reaching steady state within 20 min) cellular accumulation phases. Palmitate increased the rapid binding phase of /sup 45/Ca/sup 2 +/ uptake from 2.10 +/- 0.13 to 3.03 +/- 0.16 fmol Ca/sup 2 +//cell and caused a 2 to 3-fold increase in the slow phase. Palmitate also increased glucose uptake by a mean of 225% above control. This increase was eliminated by a 15 min preincubation with the intracellular Ca/sup 2 +/ chelator, quin 2-AMmore » (50 ..mu..M), implying that increased Ca/sup 2 +/ uptake was related to increased glucose transport. They conclude that the Ca/sup 2 +/-palmitate complex enhances Ca/sup 2 +/ uptake, which may be related to an increased ability for adipocytes to transport glucose. The Ca/sup 2 +/-palmitate complex may therefore represent a biologically active form of Ca/sup 2 +/.« less
Cyberassured Systems Engineering at Scale (2022)

Our team has developed a model-based systems engineering environment that integrates formal methods at all levels of system design. Our methodology and tools enable systems engineers to address cybersecurity concerns early in the development of complex high-assurance systems.
157 A critical role of CD40 and CD70 signaling in cDC1s in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells (2020)

<h3>Background</h3> Adoptive cell therapy (ACT) with antigen-specific CD8+ T cells is a promising approach for treating patients with various solid malignancies including melanoma. In vivo expansion of adoptively transferred T cells is one of the major determinants of successful ACT. On the other hand, a frequently overlooked consideration is that the host antigen-presenting cells affect the antitumor efficacy of ACT. Accumulating evidence suggests that tumor-residing Batf3-dependent conventional type I dendritic cells (cDC1s) play an important role in trafficking of adoptively transferred T cells into the tumor by producing chemokines such as CXCL10, and improve antitumor efficacy of ACT. However, a role of cDC1s in expansion of adoptively transferred T cells remains unclear. <h3>Methods</h3> We utilized Pmel-1 T cell receptor transgenic T cells in the B16 melanoma model to investigate the role of cDC1s in expansion of adoptively transferred tumor-specific T cells. <h3>Results</h3> While adoptive transfer of in vitro-activated Pmel-1 T cells with vaccination of cognate antigen, hgp100, agonistic anti-CD40 monoclonal antibody (mAb), and Toll-like receptor 7 (TLR7) agonist delayed the tumor growth and survival in wild type C57BL/6 mice (WT), antitumor efficacy of ACT was completely abrogated in Batf3-/- mice. Flow cytometric analysis of peripheral blood showed expansion of adoptively transferred Pmel-1 T cells was significantly compromised in WT mice but not in in Batf3-/- mice. Mechanistically, loss-of-function studies using mixed bone marrow chimera reconstituted with Batf3-/- and CD40-/- (Batf3-/-/CD40-/-), Batf3-/- and CD70-/- (Batf3-/-/CD70-/-), or Batf3-/- and CD80/86-/- (Batf3-/-/CD80/86-/-) revealed CD40-CD70 axis but not CD80/86 signaling in host cDC1s plays an important role in expansion of adoptively transferred T cells. Accordingly, overall survival of Batf3-/-/CD70-/- mixed chimeric was significantly shorter than that of Batf3-/-/WT mice, while survival of Batf3-/-/CD80/86-/- mice was similar to that of Batf3-/-/WT mice. Furthermore, induction of cDC1s by administration of Fms-like tyrosine kinase 3 receptor ligand (gain-of-function) demonstrated significantly enhanced in vivo expansion of adoptively transferred Pmel-1 T cells associated with improved tumor control and survival. <h3>Conclusions</h3> These findings elucidate a role of host cDC1s in expansion of adoptively transferred in vivo restimulated tumor-specific T cells, and identify CD40 and CD70 as key molecules.
Usefulness of a new biological adhesive agent, Gelatin-Resorcinol Formaldehyde-Glutaraldehyde glue(GRFG-glue) in treating an air leakage following lung resection. (1995)

肺手術に伴うAir leakに対し, 新しい生体接着剤GRFG glueの有用性につき検討した.対象は高齢者で気腫性病変や胸膜癒着が高度で, 肺切離面, 剥離面など肺胸膜欠損部からのAir leakが高度の症例や, 縮小手術としての区域切除等で切離面の広い症例でFibrin glueではAir leakの閉鎖が困難と判断された症例11例である.Glueの使用量は1症例当り2～4m/で, 接着層の再剥離は見られず, 塗布後の密封試験で11例中5例が完全に閉鎖し, 1例を除く他の5例も塗布部からのAir leakは殆ど見られなかった.ドレーンからのAir leak消失までの日数, 抜管時期はそれぞれ平均1.3病日, 3.6病日であった.ホルマリンの過剰塗布や接着郎以外への付着に注意すれば臨床上毒性は無かった.将来Fibrin glueに代わる有用な接着剤と思われる.
Acknowledgments (2015)

VTS, like any complex organization, is the result of the efforts of a large number of volunteers, who selflessly have volunteered their time and energy, with their only reward being the satisfaction of seeing a job well done, and the consciousness to have contributed to the dissemination of scientific knowledge through the continued success of a forum dedicated to the exchange of advances in both research and practice in VLSI Test. No words would compare to the magnitude of the efforts displayed by these volunteers. However, we would nonetheless like to register herein our personal note of thanks to the whole body of volunteers, who made it possible the organization of VTS 2015.
Acetylene hydrochlorination using Au/carbon: a journey towards single site catalysis (2017)

The replacement of mercuric chloride in the production of vinyl chloride monomer, a precursor to PVC, would greatly reduce the environmental impact of this large scale industrial process.
Up to 170Gbaud Optical Interconnects with Integrated CMOS-Silicon Photonics Transmitter (2022)

We investigate the performance boundary of integrated CMOS silicon photonics transmitters with DSP techniques. 170Gbaud OOK generation and 120Gbaud 20km transmission is achieved with a CMOS-silicon transmitter, where the driver amplifier only consumes 158mW.
Bony increased-offset reverse shoulder arthroplasty: A meta-analysis of the available evidence (2020)

Literature on BIO-RSA is limited with only one randomised controlled trial (RCT). Weak evidence exists for improved outcome scores. Range of motion is equivocal. Notching rates are significantly lower in BIO-RSA. The graft usually heals.
Densely spaced FDM coherent optical system with random access digitally tuned receiver (2003)

The authors report the results obtained with a densely spaced FDM (frequency division multiplexing) coherent optical fiber star network utilizing monolithic frequency-tunable lasers to generate optical signals frequency-shift-keyed at 200 Mb/s, which provides an optical receiver sensitivity of 74 photons/b at a bit error rate of 10/sup -9/ and random access channel selection by a computer-controlled digitally tuned receiver. The demonstration system consists of six optical channels spaced by 2.2 GHz, the minimum frequency interval possible without adjacent channel interference. The channels are generated by multiple-quantum-well distributed-Bragg-reflector lasers operating at a wavelength of 1.53 mu m. These lasers provide a narrow linewidth (2-4 MHz) that is small enough for coherent detection application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Snap judgement of publication quality (2011)

A comprehensive qualitative assessment of a researcher's contribution in a specific narrow discipline takes time and expertise. Given the shortage of both in typical situations, a researcher's productivity is often judged quantitatively by the number of publications, their acceptance ratios, and citation counts that are highly discipline-dependent. We believe such a cursory evaluation is unavoidable and suggest a more intuitive discipline-agnostic approach for perfunctory assessment. We propose a metric called peers' reputation (PR) which ties the selectivity of a publication venue with the reputations of authors' institutions. Briefly, PR conveys the selectivity of a conference with a tuple, say &lt;1/3 , 20&gt;, indicating that 1/3 of the papers at that conference are from the top 20 universities. We compute PR for networking research publication venues, and argue that PR is a better indicator of selectivity than acceptance ratio, and many conferences have similar or better PR than journals. While these insights are not necessarily new to researchers in the networking community, PR metric helps inform a dean or a provost that getting a paper accepted at MobiCom involves competing with researchers from the top 20 US universities.