gebhart/patrepeval huggingface dataset:
ChemInform Abstract: 9‐Carboxymethyl‐5H,10H‐imidazo[1,2‐a]indeno [1,2‐e]pyrazin‐4‐one‐2‐carbocylic Acid (RPR117824): Selective Anticonvulsive and Neuroprotective AMPA Antagonist. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Diamond Nonlinear Photonics (2016)

Diamond on-chip frequency combs and Raman lasers will be presented. Furthermore, efforts aimed at realization of ultra-high Q diamond cavities in the visible wavelength range, and demonstration of visible frequency combs will be discussed. Article not available.
Catechol‐Based Phosphoramidites: A New Class of Chiral Ligands for Rhodium‐Catalyzed Asymmetric Hydrogenations. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Abstract 5564: Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. (2013)

Abstract Disulfiram (DSF) is a member of the dithiocarbamate family of compounds that bind with copper and function as inhibitor of aldehyde dehydrogenase. DSF is one of the drugs approved by Food and Drug Administration for treatment of alcoholism. Recent studies have indicated anti-tumor and chemosensitizing properties of DSF. However, the molecular mechanisms of DSF action remain unclear. Here we investigated malignant pleural mesothelioma (MPM) suppressive effects of DSF and the molecular mechanisms involved. DSF inhibited growth of the murine as well as patient-derived MPM cells in part by decreasing the chymotryptic activity of the proteasome that resulted in accumulation of ubiquitinated proteins. DSF suppression of MPM growth also involved elevated apoptosis as evidenced by activation of caspase-3, elevated levels of pro-apoptotic Bax protein and cleavage of poly-(ADP-ribose)-polymerase. Our studies including gene-array based analyses further revealed that DSF suppressed a number of cell growth and metastasis-promoting genes including matrix metallopeptidase 3 and 10. DSF treatments also stimulated expression of sulfatase 1, growth arrest-specific (GAS) 6 protein, and CARP-1/CCAR1, a novel transducer of cell growth signaling. Administration of 50mg/kg DSF by daily i.p injections inhibited growth of murine MPM cell-derived tumors in vivo in part by stimulating cell growth arrest and apoptosis. Together our in vitro and in vivo studies suggest that DSF suppresses MPM growth by targeting multiple pathways that include blockage of metastasis signaling and stimulation of apoptosis, and thus holds promise as an anti-MPM agent. Citation Format: Ying Wang, Vino T. Cheryan, Shazia Jamal, Di Chen, Huanjie Yang, Lisa A. Polin, Harvey I. Pass, Q Ping Dou, Sunita Sharma, Arun K. Rishi, Anil Wali. Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5564. doi:10.1158/1538-7445.AM2013-5564
A 3.4‐in. Flexible High‐Resolution Full‐Color Top‐Emitting AMOLED Display (2013)

Abstract In this paper, we report a 3.4‐inch flexible top‐emitting AMOLED display with remarkably high resolution using oxide TFTs. Our transfer technology has an advantage of fabricating high‐performance TFTs and a high‐resolution AMOLED Display on a flexible substrate.
Differentiation of macrophages from normal human bone marrow in liquid culture. Electron microscopy and cytochemistry. (1978)

A C T To study the various stages of human mononuclear phagocyte maturation, we cultivated bone marrow in an in vitro diffusion chamber with the cells growing in suspension and upon a dialysis membrane. At 2, 7, and 14 days, the cultured cells were examined by electron microscopy and cyto- chemical techni(lues for peroxidase and for more limited analysis of acid phosphatase and arylsulfatase. Peroxidase was being synthesized in promonocytes of 2-and 7-day cultures, as evidenced by reaction pro- duct in the rough-surfaced endoplasmic reticulum, Golgi complex, and storage granules. Peroxidase syn- thesis had ceased in monocytes and the enzyme ap- peared only in some granules. By 7 days, large macrophages predominated, containing numerous peroxidase-positive storage granules, and heterophagy of dying cells was evident. By 14 days, the most prevalent cell type was the large peroxidase-negative macrophage. Thus, peroxidase is present in high concentrations in immature cells but absent at later stages, presumably a result of degranulation of peroxi- dase-positive storage granules. Clusters of peroxidase- negative macrophages with indistinct borders (epi- thelioid cells), as well as obvious multinucleated giant cells, were noted. Frequently, the interdigitating plasma membranes of neighboring macrophages showed a modification resembling a septate junction- to our knowledge, representing the first documentation of this specialized cell contact between normal macrophages. We suggest that such junctions may serve as zones of adhesion between epithelioid cells.
A New Reaction of S-Propargyl Dithiocarbonates (Xanthates) with Acid Chlorides (1995)

Substituted 1,3-dithiol-3-ones were synthesized by a novel C-C bond forming reaction involving heating a propargylic xanthate with an acid chloride at temperatures around 120°C.
Self-Similarity of Twitter Users (2021)

Earlier studies have established that the (perceived) similarity of users is highly subjective and reflects more on how people respect/admire others rather than their characteristics or behavioral similarities. We study this phenomenon among Twitter users, and while confirm that it is indeed the case, we further explore the components of similarity by investigating it using data from three categories (interactions between egos and alters, profile-based activity history, and linguistic content in the messages). We use interactions as estimation for admiration and observe that it has more impact and a higher correlation to the perceived similarity than other objective measures, including similarity based on user profiles and their use of hashtags.
Calorimetric investigation of equilibrium and thermal relaxation properties of the switchable Prussian Blue analog Na 0.32 Co[Fe(CN) 6 ] 0.74 · 3.4H 2 O (2007)

Calorimetric measurements have been performed on the Prussian Blue analog Na0.32Co[Fe(CN)6]0.74·3.4H2O. The thermal relaxation of the metastable state obtained by thermal quenching of the high temperature phase gives rise to an exothermic peak (at the "thermal relaxation temperature", TTR) which appears at higher temperature and with a larger width as the temperature scan rate increases. Values for the enthalpy and entropy changes upon the charge transfer-induced spin transition (CTIST) have been subsequently determined. The equilibrium and thermal relaxation data have been quantitatively analyzed through a mean-field cooperative dynamic model that also provides a quantitative description of the trapping process. The changes in enthalpy and "apparent" entropy during the thermal relaxation process are investigated and the evaluation of the activation energy by the Kissinger's plot is also discussed.
Predicting Operative Blood Loss During Spinal Fusion for Adolescent Idiopathic Scoliosis (2013)

Retrospective study: Level II.
Thin film 0–3 polymer/piezoelectric ceramic composites: Piezoelectric paints (1989)

Abstract In this paper we summarize our investigation of the electrical properties of thin-film 0–3 polymer-ceramic composites. The main objective of this study was to demonstrate the principle that a piezoelectric paint can indeed be prepared. Two polymers, an acrylic copolymer and a polyurethane, were utilized in our research. Both were loaded with 60–70 volume percent PZT and a coprecipitated PbTiO3. The addition of various surfactants and dispersing agents to the acrylate-based composites was necessary to aid in dispersing the ceramic particles in the polymer matrix. The hydrostatic strain and voltage coefficients, along with the ‘figures of merit’ for PZT-filled acrylic and polyurethane composites were found to be significantly larger than values reported previously for other 0–3 polymer-PZT composites. For acrylic copolymer-coprecipitated PbTiO3 composites, the hydrostatic coefficients were found to be roughly 50% larger than the comparable PZT-filled materials. For example, gh dh ranged from about 1260–1380 × 10−15 m2/N for PZT-filled and from about 1970–2140 × 10−15 m2/N for PbTiO3-loaded acrylic composites. The electrical properties of the PbTiO3-filled polyurethane were comparable to those of the corresponding PZT composites.
CYTOTOXICITY OF ADENOVIRAL-MEDIATED CYTOSINE DEAMINASE PLUS 5-FLUOROCYTOSINE GENE THERAPY IS SUPERIOR TO THYMIDINE KINASE PLUS ACYCLOVIR IN A HUMAN RENAL CELL CARCINOMA MODEL (1999)

We have demonstrated in this study that Ad-RSV-CD/5-FC is superior to Ad-RSV-TK/ACV for the treatment of human RCC in cell culture and animal models. The results are supported by the lack of gap junctional communication between RCC cells assessed by connexin-43 expression.
Restoration of Hepatitis C virus-specific CD8+ T-cell responses in patients undergoing IFN-free antiviral therapy (2014)

Virus-specific CD8+ T cells play an important role in the outcome (elimination versus persistence) and pathogenesis of hepatitis C virus (HCV) infection. The mechanisms contributing to HCV-specific CD8+ T-cell failure in chronic infection are not completely understood. Importantly, the direct influence of ongoing viral replication on virus-specific CD8+ T-cell failure could not be studied previously since standard therapy regimens contained IFN with its known toxic effects on T cells. Therefore, it was the objective of this study to answer the important question whether inhibition of ongoing viral replication by IFN-free treatments will alter the phenotype and function of HCV-specific CD8+ T cells and may even restore exhausted HCV-specific CD8+ T cells.
Comparison of Open Versus Laparoscopic Pyeloplasty Techniques in Treatment of Uretero-Pelvic Junction Obstruction (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Jun 2005Comparison of Open Versus Laparoscopic Pyeloplasty Techniques in Treatment of Uretero-Pelvic Junction Obstruction Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)60207-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Comparison of Open Versus Laparoscopic Pyeloplasty Techniques in Treatment of Uretero-Pelvic Junction Obstruction." The Journal of Urology, 173(6), p. 2023 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPiaggio L, Franc-Guimond J, Noh P, Wehry M, Figueroa T, Barthold J and González R (2007) Transperitoneal Laparoscopic Pyeloplasty for Primary Repair of Ureteropelvic Junction Obstruction in Infants and Children: Comparison With Open SurgeryJournal of Urology, VOL. 178, NO. 4S, (1579-1583), Online publication date: 1-Oct-2007. Volume 173Issue 6June 2005Page: 2023 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Postweaning positive modulation of α5GABAA receptors improves autism‐like features in prenatal valproate rat model in a sex‐specific manner (2022)

Autism spectrum disorder (ASD), as a common neurodevelopmental disorder that encompasses impairments in social communication and interaction, as well as repetitive and restrictive behavior, still awaits an effective treatment strategy. The involvement of GABAergic neurotransmission, and especially a deficit of GABA<sub>A</sub> receptors that contain the α5 subunits, were implicated in pathogenesis of ASD. Therefore, we tested MP-III-022, a positive allosteric modulator (PAM) selective for α5GABAA receptors, in Wistar rats prenatally exposed to valproic acid, as an animal model useful for studying ASD. Postweaning rats of both sexes were treated for 7 days with vehicle or MP-III-022 at two doses pharmacokinetically determined as selective, and thereafter tested in a behavioral battery (social interaction test, elevated plus maze, spontaneous locomotor activity, and standard and reverse Morris water maze). Additional rats were used for establishing a primary neuronal culture and performing calcium imaging, and determination of hippocampal mRNA levels of GABRA5, NKCC1, and KCC2. MP-III-022 prevented impairments in many parameters connected with social, repetitive and restrictive behavioral domains. The lower and higher dose was more effective in males and females, respectively. Intriguingly, MP-III-022 elicited certain changes in control animals similar to those manifested in valproate animals themselves. Behavioral results were mirrored in GABA switch and spontaneous neuronal activity, assessed with calcium imaging, and also in expression changes of three genes analyzed. Our data support a role of α5GABAA receptors in pathophysiology of ASD, and suggest a potential application of selective PAMs in its treatment, that needs to be researched in a sex-specific manner. LAY SUMMARY: In rats prenatally exposed to valproate as a model of autism, a modulator of α5GABAA receptors ameliorated social, repetitive and restrictive impairments, and, intriguingly, elicited certain autism-like changes in control rats. Behavioral results were mirrored in GABA switch and spontaneous neuronal activity, and partly in gene expression changes. This shows a role of α5GABAA receptors in pathophysiology of ASD, and a potential application of their selective modulators in its treatment.
Developmental and regional expression of three new members of the ras‐gene family in the mouse brain (1989)

We have examined the expression in the mouse nervous system of three new members of the ras protooncogene family: rab1, rab2, and rab3. Each of these genes was transcribed into messenger RNAs with different molecular weights. These transcripts has specific developmental and regional patterns of expression. In particular, for the three genes, the ratio between the heavy and light mRNAs depended strongly on developmental stage and brain region. The use of pure neuronal and glial cultures revealed that the high molecular weight transcripts were enriched in neurons and that, in the case of rab2 and rab3, their expression increased with neuronal differentiation. These results are discussed considering the sequence identities between these genes and the yeast YPTI and sec-4 genes, which are known to be implicated in post-Golgi vesicular transport and cytoskeletal stabilization. We propose that the rab genes might be of importance in the regulation of these two processes within the developing and adult nervous system.
MINIMISING INFECTION RISK: A PRE-OPERATIVE CHECKLIST (2016)

Minimizing the risk of periprosthetic joint infection (PJI) is of interest to all surgeons performing hip and knee arthroplasty. Among the most critical factors to reducing the risk of infection include the use of pre-incisional antibiotics, appropriate skin preparation with clippers (as opposed to a razor for hair removal) and the use of an alcohol-based skin preparation. Host factors are also likewise critically important including obesity, diabetes, inflammatory arthritis, renal insufficiency, skin disorders and patients who are otherwise immune-compromised. If modifiable risk factors are identified, it would seem reasonable to delay elective surgery until these can be optimised.

One other factor to consider is the nutritional status of the patient. In a study of 501 consecutive revisions, we found that serological markers suggestive of malnutrition (albumin, transferrin or total lymphocyte count) were extremely common in the revision population. Specifically, among patients who presented for treatment of a chronic infection, 53% (67 of 126) had at least one marker for malnutrition. The prevalence of serological markers of malnutrition was lower (33%) in the group of patients undergoing revision for an aseptic reason suggesting that malnutrition was a risk factor for septic failure (p < 0.001 and OR 2.1). Interestingly, malnutrition was most common among patients of normal weight but was also common among obese patients (so-called “paradoxical” malnutrition). What was more disturbing, however, that of those patients undergoing an aseptic revision, serum markers of malnutrition were associated with a 6x risk of acute postoperative infection complicating the patient's aseptic revision.

At our center, we also have studied the use of dilute betadine at the end of the case, prior to wound closure, in an attempt to decrease the load of bacteria in the wound. In a retrospective review the prevalence of acute postoperative infection was reduced from just under 1% (18/1862) to 0.15% (1 of 688; p = 0.04). It is critical that the betadine utilised be STERILE and the dilution we use is 0.35% made by diluting 17.5cc of 10% povidone-iodine paint in 500cc of normal saline. Although this is a retrospective review, it does suggest a benefit and we have not seen any problems associated with its use.
Immune response to a major epitope of p24 during infection with human immunodeficiency virus type 1 and implications for diagnosis and prognosis (1991)

A sequential inhibition enzyme-linked immunoassay (SIEIA) using a peroxidase-conjugated monoclonal antibody reacting to the sequence AAEWDRVHP of p24HIV-1 (amino acids 209 to 217 of p55) was developed in order to detect and determine the titer of antibody to this epitope in various populations of human immunodeficiency virus type 1 (HIV-1)-positive patients. There was a good correlation between SIEIA and a commercially available competition assay that uses recombinant p24 protein and polyclonal antibody to HIV-1 antigen, demonstrating the importance of the described epitope. Analysis of sera from French patients showed a decline of antibody to the AAEWDRVHP sequence associated with the progression of AIDS. No decrease was observed with serum samples from African patients. An immune response to the epitope was detected by SIEIA early in the course of seroconversion. Although our SIEIA uses a single p24 epitope, these data are in accordance with previously published studies in which antibodies to the whole p24 were analyzed. Sera reacting to p24 only (indeterminate profiles by Western blot [immunoblot]) did not bind to AAEWDRVHP. This epitope, which is conserved between HIV-1 and HIV-2/simian immunodeficiency virus, appears to be a major antigenic domain of p24. The area containing the sequence AAEWDRVHP and the corresponding monoclonal antibody may serve as a convenient alternative to whole purified p24 and polyclonal antibody in diagnostic and prognostic assays.
Gene Therapy and Therapeutic Interventions in the Auditory System (2002)

This special issue represents the third of three issues containing papers arising from the ‘Auditory Function and Dysfunction: Molecular and Physiological Mechanisms’ symposium held in Auckland, New Zealand in August 2001. It reflects on the exciting advances that are being made in our understanding of the molecular basis of cochlear development, n
Supplementary Table S1-S3 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer (2023)

&lt;p&gt;Table S1. CYP27A1 transcript is down-regulated in primary prostate tumors. Table S2. CYP27A1 transcript is down-regulated in metastatic PC relative to primary tumors. Table S3. CYP27A1 transcript levels in hormone sensitive PC relative to hormone resistant PC&lt;/p&gt;
Ferritin: Diversity and Management of Ferritin Measurement Methods (2018)

Systematic bias affects not only the measurement results, but also the therapeutic strategy to be used in accordance with the relevant guidelines, and consequently the cost of medical treatment. Key Messages: Manufacturers should reduce variability in their serum ferritin assay kits. Researchers should take into account propagation of error in the analysis of measurement values, and clinicians should evaluate laboratory data with care.
Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury (2004)

Tetracyclines exhibit significant anti-inflammatory properties, inhibit matrix metalloproteinases (MMPs), and are protective in models of ischemia-reperfusion injury (IRI). Both inflammatory cascades and MMP activation have been demonstrated to modulate microvascular permeability. Because increased microvascular permeability occurs during IRI in a variety of organ systems including the kidney, we hypothesized that minocycline, a semisynthetic tetracycline, would diminish microvascular leakage during renal IRI. To test this hypothesis, we used intravital 2-photon microscopy to examine leakage of fluorescent dextrans from the vasculature in a rodent model of IRI. Minocycline significantly reduced the extent of dextran (500 kDa) leakage from the renal microvasculature 24 h after ischemia. Although minocycline diminished leukocyte accumulation in the kidney following ischemia, areas of leukocyte accumulation did not correlate with areas of microvascular permeability in either the saline- or minocycline-pretreated animals. Minocycline diminished the perivascular increase in MMP-2 and MMP-9, as well as the increase in MMP-2 activity 24 h after ischemia. ABT-518, a specific inhibitor of MMP-2 and MMP-9, also significantly reduced the extent of dextran (500 kDa) leakage from the renal microvasculature 24 h after ischemia. Our results indicate that minocycline mitigates the renal microvascular permeability defect following IRI. This effect is spatially distinct from the effect of minocycline on leukocyte accumulation and may be related to diminished activity of MMPs on the integrity of the perivascular matrix.
ChemInform Abstract: A Novel Example for Optical Resolution of Racemic Ketones Originating from Batrachotoxin Synthesis. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figures 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion (2023)

Supplementary Figures 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion
Customizable Automated High Content Image Acquisition and Analysis for Tissue Biopsies (2022)

Abstract: Advancements in high content image analysis have led to an increase in the adoption of these techniques in basic science and clinical research. High-throughput approaches to imaging and image analysis require minimal user interventions, circumventing the often prohibitively time-consuming and unreliable standard manual analysis. In this study, we demonstrate how high content imaging (HCI) techniques, in combination with high content analysis (HCA), can be paired with more traditional manual analysis to quantify both micro- and macro-level features of biopsied tissue sections. High-resolution, full-color images of stained tissue were acquired and stitched together to reconstruct the entire tissue section, which enabled analyses that required accurate identification of a given region's location within the tissue section. A custom region of interest grid was generated that followed the curvature of the tissue. The composite images were used in two separate analyses: tissue layer thickness as a macro-level approach, and nuclei density as a micro-level approach. Ultimately, the flexibility of the HCI and HCA methodologies used in this study allowed for complex analysis of tissue that would not have been otherwise feasible.