gebhart/patrepeval huggingface dataset:
Semantics-Based News Delivering Service (2016)

This paper proposes a semantic computing application for a news delivering service collects and recommends news articles which user feels interested in based on semantic relations between terms in the articles. We define interested articles as the ones that users have curiosity and serendipity. The semantic relations between terms are represented by graphs of Linked Data. We first create News Articles Linked Data, which are news articles for recommendation to users and User’s preferences Linked Data created from the users’ preferred articles. Then, common subgraphs between two graphs are searched for the recommendation of news articles. The experiment showed that the curiosity score is 3.30 (min:0, max:4), and the serendipity score is 2.93 in our approach, but a baseline method indicated the curiosity score: 3.03 and the serendipity score: 2.79. Thus, we confirmed that our approach is more effective than the baseline method. In the future, we will deploy our semantic technology to practical use for automatically delivering information selected from a vast amount of news sources.
Primi risultati dello studio OBSERVANT II: caratteristiche cliniche dei pazienti con stenosi aortica sottoposti a procedure transcatetere con dispositivi di nuova generazione (2020)

The first results of the OBSERVANT II study show that patients undergoing TAVI with new-generation devices are elderly, have a lower risk profile than patients enrolled in the OBSERVANT study but comparable mean values of EuroSCORE II. The in-hospital mortality rate for patients enrolled in the OBSERVANT II study is lower than that recorded in the OBSERVANT study across all the EuroSCORE II risk classes.
Study of Polymer−Plasticizer Interaction by 13C CP/MAS NMR Spectroscopy:  Poly(vinyl chloride)−Bis(2-ethylhexyl) Phthalate System (1996)

Solid state 13C CP/MAS studies of poly(vinyl chloride) (PVC)−bis(2-ethylhexyl) phthalate (DOP) have been carried out to elucidate the dynamics of polymer−plasticizer interaction at the molecular level. 13C NMR spectra, spin−lattice relaxation time T1(C) and spin−spin relaxation time T2(C) were obtained for various PVC−DOP samples. Line widths of 〉CHCl show a sharp increase due to the strong hydrogen-bonding interaction between the 〉CO (ester) group of DOP and 〉CHCl of PVC with various concentrations of DOP. The spin−lattice relaxation time T1(C) also confirms the presence of a strong interaction due to hydrogen bonding. The less mobile intermediate phase is mostly affected by the presence of plasticizer. The spin−spin relaxation time T2(C) shows that DOP is a mixed type plasticizer showing the features of both molecular and structural type plasticization.
Design and demonstration of a small-animal up-conversion imager (2008)

This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.
Guest Editorial Special Issue on Microwave Photonics (2022)

The 43 papers in this special issue are expanded versions of papers presented at the Topical Meeting on Microwave Photonics 2021 (MWP2021) that was held in November 15–17, 2021.
Context-based arithmetic encoding of 2-dimensional shape sequences (1997)

Keywords: LTS1 Reference LTS-CONF-1997-032 Record created on 2006-06-14, modified on 2016-08-08
Safety and immunogenicity of 2010–2011 A/H1N1pdm09-containing trivalent inactivated influenza vaccine in adults previously given AS03-adjuvanted H1N1 2009 pandemic vaccine (2013)

Many Canadians received a novel AS03-adjuvanted vaccine during the 2009 influenza A/H1N1 pandemic. Longer term implications of adjuvant use were unclear: would anti-H1N1 immune responses persist at high levels and, if so, could that result in increased or unusual adverse effects upon re-exposure to H1N1pdm09 antigen in the trivalent influenza vaccine (TIV) for 2010-11? To answer these questions, adults given AS03-adjuvanted H1N1pdm09 vaccine (Arepanrix®, GSK Canada) 9-10 mo earlier were enrolled in an evaluator-blinded, crossover trial to receive 2010-2011 non-adjuvanted TIV (Fluviral®, GSK Canada) and placebo 10 d apart, in random order. Adverse effects were monitored for 7 d after each injection. Vaccine-attributable adverse event (VAAE) rates were calculated by subtracting rates after placebo from those after vaccine. Blood was obtained pre-vaccination and 21-30 d afterward to measure hemagglutination inhibiting antibody titers. In total, 326 participants were enrolled and 321 completed the study. VAAE rates were low except for myalgia (18.6%) and injection site pain (63.2%). At baseline, H1N1pdm09 titers ≥ 40 were present in 176/325 subjects (54.2%, 95% confidence interval 48.6, 59.7), with a geometric mean titer (GMT) of 37.4 (95% CI 32.8, 42.6). Post-immunization, 96.0% (95% CI 92.3, 97.8) had H1N1pdm09 titers ≥ 40, with GMT of 167.4 (95% CI 148.7, 188.5). Responses to both influenza A strains in TIV were similar, implying no lasting effect of adjuvant exposure. In summary, titers ≥ 40 persisted in only half the participants 9-10 mo after adjuvanted pandemic vaccine but were restored in nearly all after TIV vaccination, with minimal increase in adverse effects.
ChemInform Abstract: Perfluoroalkyl Substituted Arylphosphanes as Ligands for Homogeneous Catalysis in Supercritical Carbon Dioxide. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target (2019)

Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδ over Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicological outcomes at similar exposure levels to compound 19.
Dewatering of Arthrospira platensis microalgae suspension by electrofiltration (2022)

Harvesting microalgae has presented many challenges in the past, especially when taking into account the final dryness of the product and the energy requirements for the drying process. This study investigates the use of dead-end electrofiltration to dewater an Arthrospira platensis suspension under different pressures (1 to 4 bar) and electric current densities (30 to 80 A/m2). Filtration without an electric field helped reach a final cake dryness in the range of 13.3-15%. Electrofiltration was found to be a more effective dewatering method, reaching a final cake dryness of up to 20.8% with an energy consumption of 0.105 kWh/kg water removed, which is significantly lower than the energy consumption reported in literature. Increasing the electric current density helped increase the cake dryness, whereas increasing the operating pressure was not effective enough due to the high cake compressibility. Electrofiltration also modifies the filtrate and cake properties due to the electrolysis reactions.
Symmetry, stability, and computation of degenerate lasing modes (2017)

We present a general method to obtain the stable lasing solutions for the steady-state ab initio lasing theory (SALT) for the case of a degenerate symmetric laser in two dimensions (2D). We find that under most regimes (with one pathological exception), the stable solutions are clockwise and counterclockwise circulating modes, generalizing previously known results of ring lasers to all 2D rotational symmetry groups. Our method uses a combination of semianalytical solutions close to lasing threshold and numerical solvers to track the lasing modes far above threshold. Near threshold, we find closed-form expressions for both circulating modes and other types of lasing solutions as well as for their linearized Maxwell-Bloch eigenvalues, providing a simple way to determine their stability without having to do a full nonlinear numerical calculation. Above threshold, we show that a key feature of the circulating mode is its “chiral” intensity pattern, which arises from spontaneous symmetry breaking of mirror symmetry, and whose symmetry group requires that the degeneracy persists even when nonlinear effects become important. Finally, we introduce a numerical technique to solve the degenerate SALT equations far above threshold even when spatial discretization artificially breaks the degeneracy.
Cardiac Microenviroment Program Human Aminotic Fluid‐derived Stem Cell To Cardiac Phenotype (2009)

Objective It is believed that certain microenvironment can induce differentiation of stem cell into a specific cell lineage. Therefore, we carried out in vitro coculture experiments to investigate the potential of human amniotic fluid‐derived stem cell (hAFS) to differentiate along cardiac lineage. Our long‐term goal is to explore the feasibility of using this cell source for cardiac cell therapy. Methods Neonatal rat Cardiomyocytes (NRVM) were obtained by enzymatic digestion of ventricles from neonatal Sprague‐Dawley rats and plated on 1% gelatin coated coverslips. hAFS cells were labeled by PKH26, cultured directly with NRVM. At different time interval, cells were stained with cardiac specific antibodies. For dye transfer experiment, NRVM were preloaded by calcein‐AM and cocultured with PKH26 labeled hAFS. Results As early as 24 hours after initiation of coculture, contracting PKH26‐positive cells were observed. However, their number was low. After 14 days of coculture, immunostaining detected PKH26 positive cells colocalized with cardiac myosin heavy chain, cardiac Troponin T and connxin 43 positive cells. We further conducted dye transfer experiments to test coupling between NRVM and hAFS cells. 18 hour after initiation of coculture, calcein‐AM and PKH26 dual positive cells was observed, suggesting the existence of coupling between the two cell types, possibly through connexin 43.
Prediction of thermal coagulation from the instantaneous strain distribution induced by high-intensity focused ultrasound (2017)

The targeting of the ultrasound beam and the prediction of thermal lesion formation in advance are the requirements for monitoring high-intensity focused ultrasound (HIFU) treatment with safety and reproducibility. To visualize the HIFU focal zone, we utilized an acoustic radiation force impulse (ARFI) imaging-based method. After inducing displacements inside tissues with pulsed HIFU called the push pulse exposure, the distribution of axial displacements started expanding and moving. To acquire RF data immediately after and during the HIFU push pulse exposure to improve prediction accuracy, we attempted methods using extrapolation estimation and applying HIFU noise elimination. The distributions going back in the time domain from the end of push pulse exposure are in good agreement with tissue coagulation at the center. The results suggest that the proposed focal zone visualization employing pulsed HIFU entailing the high-speed ARFI imaging method is useful for the prediction of thermal coagulation in advance.
MODL-06. PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA (2020)

Abstract Treatment for medulloblastoma (MB) is typically ineffective for MYC amplified or metastatic SHH, Group 3 and 4 subgroups. Promising preclinical and clinical results have been obtained in brain cancers treated with ONC-201, a selective antagonist of DRD2, a G-protein coupled receptor that regulates prosurvival pathways. Herein, we report the activity of ONC-201 and ONC-206, which has increased non-competitive antagonism of DRD2, against MB. We treated three different MB cell types representative of SHH- and Group 3-like cells, with varied levels of DRD2 expression, and consistently observed increased cell death in a dose-dependent manner at lower doses of ONC-206 compared to ONC-201. We also evaluated ClpP as an additional drug target in MB. ClpP is a mitochondrial protease that has been shown to directly bind and be activated by ONC 201, and is highly expressed at the protein level across pediatric MB, malignant glioma and ATRT, but not normal brain. We observed that similar to ONC-201, ONC-206 treatment of MB cells induces the restoration of mitochondrial membrane potential to the non-proliferative state, degradation of the mitochondrial substrate SDHB, reduction in survivin and elevation in ATF4 (integrated stress response). Importantly, ONC-206 treatment induced significant cell death of patient-derived SHH, WNT, and Group 3 tumors ex vivo and Group 4 cells in vitro, while having no observable toxicity in normal brain. Efficacy studies of ONC-206 against MB in vivo will be reported in preparation for a planned Phase I study of ONC-206 in children with malignant brain tumors.
Targeting serum antibody for cancer diagnosis: a focus on colorectal cancer (2007)

The ability of the immune system to magnify the appearance of disease by generating relatively large amounts of antibody in response to small amounts of disease makes it a natural biosensor, and serum antibodies have emerged as promising biomarkers for the detection of cancer. This review summarizes recent progress in targeting serum antibodies for cancer diagnosis, with a particular focus on colorectal cancer (CRC). Several serum antibodies have been detected at increased levels in CRC patients, including p53, carcinoembryonic antigen, Ras, topoisomerase II-alpha, histone deacetylase 3 and 5, ubiquitin C-terminal hydrolase L3, tropomyosin and cyclin B1. As each antibody is only present in a limited proportion of patients (usually < 40%), a combination of serum antibodies that defines the 'immunological signature' of cancer needs to be developed. High-throughput methods to identify new serum antibodies for cancer diagnosis are also reviewed.
Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A (2007)

Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc-binding protein with a complex fold that is difficult to simulate computationally. We conducted multiple molecular dynamics simulations of the endopeptidase in complex with a previously described inhibitor (K(i) (app) of 7+/-2.4 microM) using the cationic dummy atom approach. Based on our computational results, we hypothesized that introducing a hydroxyl group to the inhibitor could improve its potency. Synthesis and testing of the hydroxyl-containing analog as a BoNTA endopeptidase inhibitor showed a twofold improvement in inhibitory potency (K(i) (app) of 3.8+/-0.8 microM) with a relatively small increase in molecular weight (16 Da). The results offer an improved template for further optimization of BoNTA endopeptidase inhibitors and demonstrate the effectiveness of the cationic dummy atom approach in the design and optimization of zinc protease inhibitors.
Processing assisted self assembly of nonlinear optical polymers (2002)

We explore a number of polymer architectures with the objective of fabricating intrinsically polar polymer films for applications such as electro-optic switches and signal modulators for high bandwidth data processing. The goal of this work is to offer an alternative to the poled polymer approach in order to avoid high temperature processing and high electric fields. This paper reports progress toward achieving this goal.
Synthetic, Optical and Theoretical Study of Alternating Ethylenedioxythiophene–Pyridine Oligomers: Evolution from Planar Conjugated to Helicoidal Structure towards a Chiral Configuration (2016)

A series of alternating 3,4-ethylenedioxythiophene-alkynylpyridine oligomers (DA)<sub>n</sub> with increased solubility are synthesized and their photophysical properties and nonlinear optical properties are investigated. Their quadratic polarizabilities are determined from hyper-Rayleigh scattering experiments to obtain information on their conformations in solution. These chromophores, based on the alternation of electron-rich (D) and electron-deficient (A) moieties, exhibit optical properties that arise from the combination of dipolar and helicoidal features in the (DA)<sub>n</sub> homologue series where n=1-4. The transition from dipolar conjugated planar structures (n=1, 2) to helicoidal structures (n=3, 4) is clearly evidenced by results from symmetry-sensitive second-order nonlinear optical experiments. This suggests an approach towards highly efficient chiral chromophores for second-order nonlinear optics. Interestingly, this structural evolution also has significant impact on the photophysical properties: both absorption and fluorescence emission show bathochromic and hyperchromic shifts with increasing number of repeating units in the dipolar planar derivatives (n=1-2) but show saturation effects in the helicoidal structures (n=2-4). In addition, the helicoidal structures show sizeable two-photon absorption at 700-750 nm (40-100 GM) for compounds lacking either electron-donating or electron-withdrawing substituents.
Issues and nonissues on a 193-nm step-and-scan system in production (2000)

With the delivery of 193nm exposure tool to several production fabs in the past year, we are now able to identify potential issues with this technology. For 193 nm lithoghpray, lifetime issues associated with the optical elements have been a big concern in the industry. Early learnings of optical component lifetimes for a 193nm step- and-scan system in pilot lien operation are reviewed. The performance and stability of line-narrowed ArF excimer lasers have also been unknowns in a production fab until now. High voltage and pulse length trends on the ArF laser are discussed. Data for lens heating effects on focus is presented. Stray light data will also be included in this paper. Observations related to the practical operation of a 193nm exposure tool as well as 193nm specific error modes will be shared. Finally, key areas where improvement is needed to ensure that 193nm lithography will be a cost- effective manufacturing technology are identified.
Multiple impacts: A state transition diagram approach (2012)

Impact happens when two or more bodies collide, generating very large impulsive forces in a very short period of time during which kinetic energy is first absorbed and then released after some loss. This paper introduces a state transition diagram to model a frictionless multibody collision. Each state describes a different topology of the collision characterized by the set of instantaneously active contacts. A change of state happens when a contact disappears at the end of restitution, or when a disappeared contact reappears as the relative motion of two bodies goes from separation into penetration. Within a state, (normal) impulses are coupled differentially subject to relative stiffnesses at the active contact points and the strain energies stored there. Such coupling may cause restart of compression from restitution during a single impact. Impulses grow along a bounded curve with first-order continuity, and converge during the state transitions. To solve a multibody collision problem with friction and tangential compliance, the above impact model is integrated with a compliant impact model. The paper compares model predictions to a physical experiment for the massé shot, which is a difficult trick in billiards, with a good result.
Ionic transport in electrostatic Janus Membranes. An explicit solvent\n molecular dynamic simulation (2021)

Janus --or two-sided, charged membranes offer promise as ionic current\nrectifiers. In such systems, pores consisting of two regions of opposite charge\ncan be used to generate a current from a gradient in salinity. The efficiency\nof \\textcolor{black}{nanoscale} Janus pores increases dramatically as their\ndiameter becomes smaller. However, little is known about the underlying\ntransport processes\\textcolor{black}{, particularly under experimentally\naccessible conditions}. In this work, we examine the molecular basis for\nrectification in Janus nanopores using an applied electric field. Molecular\nsimulations with explicit water and ions are used to examine the structure and\ndynamics of all molecular species in aqueous electrolyte solutions.\n\\textcolor{black}{For several macroscopic observables, the results of such\nsimulations are consistent with experimental observations on asymmetric\nmembranes. Our analysis reveals a number of previously unknown features,\nincluding a pronounced local re-orientation of water molecules in the pores,\nand a segregation of ionic species that has not been anticipated by previously\nreported continuum analyses of Janus pores. Using these insights, a model is\nproposed for ionic current rectification in which electric leakage at pore\nentrance controls net transport.\n
Probabilistic visual concept trees (2010)

This paper presents probabilistic visual concept trees, a model for large visual semantic taxonomy structures and its use in visual concept detection. Organizing visual semantic knowledge systematically is one of the key challenges towards large-scale concept detection, and one that is complementary to optimizing visual classification for individual concepts. Semantic concepts have traditionally been treated as isolated nodes, a densely-connected web, or a tree. Our analysis shows that none of these models are sufficient in modeling the typical relationships on a real-world visual taxonomy, and these relationships belong to three broad categories -- semantic, appearance and statistics. We propose probabilistic visual concept trees for modeling a taxonomy forest with observation uncertainty. As a Bayesian network with parameter constraints, this model is flexible enough to account for the key assumptions in all three types of taxonomy relations, yet it is robust enough to accommodate expansion or deletion in a taxonomy. Our evaluation results on a large web image dataset show that the classification accuracy has considerably improved upon baselines without, or with only a subset of concept relationships