gebhart/patrepeval huggingface dataset:
196 Enhancing Neuromodulation-Induced Analgesia Through Personalized Neuro-Visual Stimulation (2018)

Krishna, Vibhor MD; Solca, Marco; Serino, Andrea; Geist, Thomas; Young, Nicole PhD; Rezai, Ali R MD; Blanke, Olaf Author Information
On heavy traffic approximations for transient characteristics of M/M/∞ queues (1996)

In this paper, transient characteristics related to excursions of the occupation process of M/M/ ∞ queues are studied, when the excursion level is large and close to the mean offered load. We show that the classical diffusion approximation by an Ornstein–Uhlenbeck (OU) process captures well the average values of the transient variables considered, while the asymptotic distributions of these variables depart from those corresponding to the OU process. They exhibit, however, equivalent tail behaviour at infinity and numerical evidence shows that they are amazingly close to each other over the whole half-line.
Maintenance Olaparib in Patients With Newly Diagnosed Advanced Ovarian Cancer (2019)

(Abstracted from N Engl J Med 2018;379:2495–2505) Standard-of-care therapy for patients newly diagnosed with advanced ovarian cancer consists of frontline cytoreductive surgery and adjuvant platinum chemotherapy. Approximately 70% of these patients have a relapse within 3 years.
A Characterization of the Performance of a MEMS Gyroscope in Acoustically Harsh Environments (2010)

Microelectromechanical systems (MEMS) gyroscopes are typically smaller and less expensive than their macroscale counterparts. For this reason, they are being used in many new applications, including in harsh environments. It has been well documented that the performance of unprotected MEMS gyroscopes can be deleteriously affected by exposure to mechanical shock or high-frequency vibrations. The results of this investigation experimentally demonstrate that MEMS gyroscopes are also susceptible to high-power high-frequency acoustic noise when acoustic energy frequency components are close to the resonating frequency of the gyroscope's proof mass. Additionally, due to microfabrication tolerances and the resulting differences between otherwise identical devices, there can be significant differences in the acoustically sensitive bandwidth between otherwise identical MEMS gyroscopes. This phenomenon is characterized for the ADXRS300 MEMS gyroscope.
Sensorless current mode control-an observer-based technique for DC-DC converters (2001)

Sensorless current mode (SCM) control is an observer method that provides the operating benefits of current mode control without current sensing. SCM has significant advantages over both conventional peak and average current-mode control techniques in noise susceptibility and dynamic range in both continuous mode and discontinuous mode. The method supports line and bulk load regulation, and reduces control complexity to a single loop. It also supports conventional two-loop control for tight load regulation. Encompassing one-cycle control as a special case, the general SCM method is a public domain control technique.
Measurement and modeling of on-chip transmission line effects in a 400 MHz microprocessor (1998)

On-chip interconnect delays are becoming an increasingly important factor for high-performance microprocessors. Consequently, critical on-chip wiring must be carefully optimized to reduce and control interconnect delays, and accurate interconnect modeling has become more important. This paper shows the importance of including transmission line effects in interconnect modeling of the on-chip clock distribution of a 400 MHz CMOS microprocessor. Measurements of clock waveforms on the microprocessor showing 30 ps skew were made using an electron beam prober. Waveforms from a test chip are also shown to demonstrate the importance of transmission line effects.
A search for the dimuon decay of the Standard Model Higgs boson with the ATLAS detector (2020)

A search
Occipitocervical Vertical Distraction Injuries (2008)

Axial distraction across the cranio-vertebral junction can produce either OAD or AAD. The SCL and ICL dimensions, alar ligament orientations, and apical ligament presence may affect the injury site. Visualization with 3-T MRI allows better understanding of the injury mechanism and location, which is important clinically in selecting single- or multilevel fixation.
ModLS: Post-Translational Modification Localization Scoring with Automatic Specificity Expansion (2012)

Probability-based localisation scoring of fragment mass-spectrum phosphorylation site identifications has become common practice to confirm search engine modification assignments, and indicate the degree of certainty with which they are defined. Localisation of modifications other than phosphorylation is also required but is less commonly supported by current tools. These other modifications, such as hydroxylation, may have broad aminoacid specificity, and can be misassigned when the correct specificity is not considered in an MS database search. In addition, localisation software is often specific to a particular MS/MS search engine, and cannot be used to localise modifications identified by multiple search engines. ModLS, a new tool within our freely-available Central Proteomics Facilities Pipeline (CPFP), applies a localisation scoring method to arbitrary post-translational modifications (PTMs). As well as localising PTMs based on amino-acid specificities are included in the initial search, ModLS can automatically consider additional specificities from UniMod. This can help avoid ‘correct modification, incorrect amino-acid’ errors which can occur when data is searched using only a subset of PTM specificities. Localisation scoring can be performed on the results from any search engine incorporated within the pipeline, or where the output of individual search engines is combined to give increased coverage. We demonstrate the performance of ModLS using a publicly available phosphorylated peptide dataset, showing that it outperforms the recently characterised Mascot Delta Score approach for CID and MSA data, and is comparable for HCD data. In addition, we show the utility of automatic specificity expansion using hydroxylated and methylated peptide data. ModLS is a user-friendly localisation tool for arbitrary modifications. Its inclusion within CPFP allows PTM localisation to be performed quickly and easily on large or small result sets, from multiple search engines. Specificity expansion, introduced in ModLS, allows misassignments of modifications due to incomplete consideration of specificities to be identified and minimised.
Quasiparticle alignments andα-decay fine structure of175Pt (2014)

Excited states and decay properties of ${}^{175}$Pt have been investigated using the ${}^{92}$Mo${(}^{86}\mathrm{Sr},2pn)$ fusion-evaporation reaction. The JUROGAM I $\ensuremath{\gamma}$-ray spectrometer and the GREAT spectrometer were used in conjunction with the gas-filled recoil separator RITU for the measurement of the radiation at the target and focal plane positions, respectively. Two new band structures, assigned to be based on the ${I}^{\ensuremath{\pi}}=({{}^{7}{/}_{2}}^{\ensuremath{-}})$ ground state in ${}^{175}$Pt, have been established and the known yrast band has been extended up to ${I}^{\ensuremath{\pi}}=({{}^{49}{/}_{2}}^{+})$. Rotational properties of the excited states in ${}^{175}$Pt have been investigated within the cranked shell-model formalism. The low-frequency changes in the alignments of the positive- and negative-parity bands are interpreted as a sign of proton-pair excitations in the rotating core. Furthermore, the $\ensuremath{\alpha}$-decay measurements reveal a candidate for a fourth $\ensuremath{\alpha}$-decay branch in ${}^{175}$Pt, feeding a non-yrast state in ${}^{171}$Os.
Fostering interprofessional teamwork in an academic medical center: Near‐peer education for students during gross medical anatomy (2014)

The purpose of this report is to describe student satisfaction with a near-peer interprofessional education (IPE) session for physical therapy and medical students. Ten senior physical therapy students worked in peer-groups to develop a musculoskeletal anatomy demonstration for first-semester medical students. Together with their classmates, they demonstrated observation, palpation, and musculoskeletal assessment of the shoulder and scapular-thoracic articulation to medical student dissection groups in the Gross Anatomy laboratory. The medical students were encouraged to consider the synergistic function of shoulder structures and the potential impact of a selected pathology: rotator cuff injury. The session provided the medical students with an opportunity to integrate their new anatomical knowledge into a framework for clinical musculoskeletal evaluation. The experience offered senior physical therapy students an opportunity to work in teams with their peers, internalize and adapt to constructive feedback, and seek common ground with members of another profession. Both student groups reported a high degree of satisfaction with the sessions and expressed a desire for further interaction. These positive perceptions by student stakeholders have prompted us to consider additional IPE exchanges for the anatomy course in the upcoming school year. Given the positive outcome of this descriptive study, we now plan to systematically test whether near-peer IPE interactions can enhance the degree that students learn key anatomical concepts.
Production of New Functionalized Polymer Nanoparticles and Use for Manufacture of Novel Nanobiocatalysts (2020)

Abstract New nanoparticles are synthesized through emulsion polymerization, using distinct comonomers (styrene, divinylbenzene, glycidyl methacrylate and pentafluorostyrene). Then, for the first time, two strategies are adopted to functionalize such nanoparticles using benzylamine and thiophenol: (i) after the manufacture of the nanoparticles; and (ii) in situ during the polymerization reaction. Afterwards, the functionalized nanoparticles are used as nanosupports for immobilization of lipase B from Candida antarctica and the performance of the novel nanobiocatalysts are evaluated. It is shown that the nanoparticles exhibit different properties (specific areas ranging from 34 m 2 g −1 to 324 m 2 g −1 ; and contact angles ranging from 29° to 126°), indicating that both procedures can be used to adjust the properties of the polymer supports. Moreover, the nanobiocatalysts are applied successfully in hydrolysis and esterification reactions, exhibiting higher activities than the non‐functionalized biocatalysts. It is also observed that more hydrophilic supports result in more active biocatalysts in hydrolysis (27 ± 1 U g −1 ) and intermediate hydrophobic matrices conduct to more active biocatalysts in esterification reactions (1564 ± 50 U g −1 ). It is shown that highly hydrophobic surfaces may cause a significant decrease in the activity of such biocatalysts, probably due to distortions on the enzyme active center and to more intense chemical partitioning effects.
Mapping Human Whole-Brain Structural Networks with (2007)

Understanding the large-scale structural network formed by neurons is a major challenge in system neuroscience. A detailed connectivity map covering the entire brain would therefore be of great value. Based on diffusion MRI, we propose an efficient methodology to generate large, comprehensive and individual white matter connectional datasets of the living or dead, human or animal brain. This non-invasive tool enables us to study the basic and potentially complex network properties of the entire brain. For two human subjects we find that their individual brain networks have an exponential node degree distribution and that their global organization is in the form of a small world.
ChemInform Abstract: Pd‐Catalyzed Aminations of Aryl Triazolones: Effective Synthesis of Hydroxyitraconazole Enantiomers. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SiGe MMIC power amplifier with on-chip lineariser for X-band applications (2009)

An X-band linear power amplifier with an on-chip lineariser is developed using a 0.25 µm SiGe HBT BiCMOS process. The proposed on-chip lineariser improves the 1 dB compression to as much as 3.4 dB with no additional DC power consumption. Under a 3.3 V DC power supply, the single-stage cascode amplifier shows a measured small-signal gain of 12.2 dB and output P1 dB of 20.8 dBm, with power added efficiency of 27.4% at the operating frequency range 8.5–10.5 GHz.
Sum rate maximizing joint processing with limited backhaul and tree topology constraints (2016)

Coordinated downlink multi-point transmission with joint processing is considered for weighted sum rate maximization with limited backhaul connectivity. The cooperating base stations are assumed to form a network with a tree topology. The limited backhaul capacity is modeled as the maximum number of active users per base station. The combinatorial user admission problem is solved via a novel approach based on the alternating method of multipliers (ADMM), which divides the joint transmit beamformer design and the user allocation into separate subproblems each with a tractable complexity. In addition to the ADMM design, we propose a low complexity ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> norm relaxation technique, which circumvents the combinatorial user allocation problem. The proposed schemes are shown to provide improved sum rate when compared to conventional coordinated beamforming and greedy user admission.
Low threshold blue conjugated polymer DFB lasers (2006)

We report low threshold blue polyfluorene distributed-feedback (DFB) lasers. Second-order lasers exhibit a laser threshold of 0.28 nJ/pulse while the threshold is reduced to 0.16 nJ/pulse for first-order gratings. Laser diode pumping is demonstrated.
A new polymorphic probe on chromosome 3p: λLIB31-57′ (D3S213) (1990)

XLIB31-57' is a 6.6 kb EcoRI fragment isolated from a Charon 21A human chromosome 3 library (1). Polymorphism: BglII digestion of genomic DNA and hybridization with the probe detects a two allele polymorphism: 6.8 kb (B1) and 6.1 kb (B2). A 2.6 kb constant band was present. Frequency: Estimated from 30 unrelated Caucasians. Bi : 0.65 B2 : 0.35 Not Polymorphic For: BamHI, Dral, EcoRI, HinduI, HinfI, MspI, Pvull, RsaI and TaqI. Chromosomal Localization: Using a somatic cell hybrid panel (2) which was based on linkage groups anchored to physically localized markers, the probe was assigned to the short arm of chromosome 3 between 3p24 and 3p25. Mendelian Inheritance: Mendelian inheritance has been demonstrated in three two-generation von Hippel-Lindau disease (vHL) families. Probe
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X (2013)

Neisseria meningitidis is a major cause of bacterial meningitis worldwide, especially in the African meningitis belt, and has a high associated mortality. The meningococcal serogroups A, W, and X have been responsible for epidemics and almost all cases of meningococcal meningitis in the meningitis belt over the past 12 y. Currently no vaccine is available against meningococcal X (MenX). Because the development of a new vaccine through to licensure takes many years, this leaves Africa vulnerable to new epidemics of MenX meningitis at a time when the epidemiology of meningococcal meningitis on the continent is changing rapidly, following the recent introduction of a glycoconjugate vaccine against serogroup A. Here, we report the development of candidate glycoconjugate vaccines against MenX and preclinical data from their use in animal studies. Following optimization of growth conditions of our seed MenX strain for polysaccharide (PS) production, a scalable purification process was developed yielding high amounts of pure MenX PS. Different glycoconjugates were synthesized by coupling MenX oligosaccharides of varying chain length to CRM197 as carrier protein. Analytical methods were developed for in-process control and determination of purity and consistency of the vaccines. All conjugates induced high anti-MenX PS IgG titers in mice. Antibodies were strongly bactericidal against African MenX isolates. These findings support the further development of glycoconjugate vaccines against MenX and their assessment in clinical trials to produce a vaccine against the one cause of epidemic meningococcal meningitis that currently cannot be prevented by available vaccines.
Broadband variable optical attenuator in silica waveguide technology (2002)

A broad-band variable optical attenuator, with 1 dB flatness over the 1530-1560 range and with variable attenuation up to 20 dB, is described. It is based on cascaded Mach-Zehnders and fabricated in silica waveguide technology.
Influence of high biomass concentrations on alkane solubilities (2000)

Alkane solubilities were measured experimentally for high-density biomass. The resulting Henry's law constants for propane were found to decrease significantly for both dense yeast suspensions and an actual propane-degrading biofilm consortium. At the biomass densities of a typical biofilm, propane solubility was about an order of magnitude greater than that in pure water. For example, a dense biofilm had a propane Henry's law constant of 0.09 ± 0.04 atm m3 mol−1 compared to 0.6 ± 0.1 atm m3 mol−1 measured in pure water. The results were modeled with mixing rules and compared with octanol-water mixtures. Hydrogels (agar) and salts decreased the alkane solubility. By considering a theoretical solubility of propane in dry biomass, estimates were made of intrinsic Henry's law constants for propane in pure yeast and biomass, which were 13 ± 2 and 5 ± 2 atm kg biomass mol−1 for yeast and biofilm consortium, respectively. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 68: 279–284, 2000.
Factors Involved in GLUT-1 Glucose Transporter Gene Transcription in Cardiac Muscle (1999)

Glucose constitutes a major fuel for the heart, and high glucose uptake during fetal development is coincident with the highest level of expression of the glucose transporter GLUT-1 during life. We have previously reported that GLUT-1 is repressed perinatally in rat heart, and GLUT-4, which shows a low level of expression in the fetal stage, becomes the main glucose transporter in the adult. Here, we show that the perinatal expression of GLUT-1 and GLUT-4 glucose transporters in heart is controlled directly at the level of gene transcription. Transient transfection assays show that the -99/-33 fragment of the GLUT-1 gene is sufficient to drive transcriptional activity in rat neonatal cardiomyocytes. Electrophoretic mobility shift assays demonstrate that the transcription factor Sp1, a trans-activator of GLUT-1 promoter, binds to the -102/-82 region of GLUT-1 promoter during the fetal state but not during adulthood. Mutation of the Sp1 site in this region demonstrates that Sp1 is essential for maintaining a high transcriptional activity in cardiac myocytes. Sp1 is markedly down-regulated both in heart and in skeletal muscle during neonatal life, suggesting an active role for Sp1 in the regulation of GLUT-1 transcription. In all, these results indicate that the expression of GLUT-1 and GLUT-4 in heart during perinatal development is largely controlled at a transcriptional level by mechanisms that might be related to hyperplasia and that are independent from the signals that trigger cell hypertrophy in the developing heart. Furthermore, our results provide the first functional insight into the mechanisms regulating muscle GLUT-1 gene expression in a live animal.
Phenytoin Intoxication Induced by Fluvoxamine (2001)

A patient had phenytoin intoxication after administration of fluvoxamine, a selective serotonin reuptake inhibitor. The serum concentration of phenytoin increased dramatically from 16.6 to 49.1 microg/mL when fluvoxamine was coadministered, although the daily dosage of phenytoin and other drugs had not changed. During phenytoin and fluvoxamine treatment, ataxia, a typical side effect of phenytoin, was observed. The genotypes of CYP2C9 and 2C19, the enzymes responsible for phenytoin metabolism, were homozygous for the wild-type alleles (CYP2C9*1/*1 and 2C19*1/ *1). The interaction may be a result of inhibition of both CYP2C9 and 2C19 by fluvoxamine.
Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. (1994)

Developing T cells are positively selected on the basis of their recognition of polymorphic MHCs (major histocompatibility molecules). The CD4 and CD8 co-receptors, together with a compatible TCR-alpha beta, bind class II and class I MHC, respectively, delivering a signal that allows T cell maturation to proceed along the appropriate co-receptor lineage. During development, thymocytes first co-express CD4 and CD8 and subsequently commit to a single co-receptor phenotype. Debate exists over the stage at which positive selection occurs. Positive selection may precede or accompany co-receptor lineage commitment or occur subsequent to the acquisition of a single co-receptor phenotype. We developed transgenic (TG) mice expressing human CD4 (huCD4) on T cells. To study differentiation of CD8+ cells, huCD4 TG mice were bred with mice lacking class I MHC (class I-). This enabled us to assess maturation of mCD8+mCD4+huCD4+ thymocytes to mCD8+mCD4-huCD4+ cells after interaction between huCD4 and mclass II MHC. In the absence of huCD4, class I- mice failed to produce mCD8+ cells. However, expression of huCD4 allowed development of mCD8+mCD4-huCD4+ T cells, suggesting that selection of cells precommitted to the mCD8+mCD4- lineage occurred. Importantly, CD8+ T cells were increased in both the thymus and the periphery of huCD4 TG x class I- animals, indicating their intrathymic origin. V beta 14+ CD8+ T cells were also increased, as predicted for positive selection of CD8+ cells bearing class II-reactive TCRs. These data provide evidence that positive selection occurs at a late stage of thymocyte differentiation, after commitment to the CD8 lineage.
Increased Expression of Herpes Virus-Encoded hsv1-miR-H18 and hsv2-miR-H9-5p in Cancer-Containing Prostate Tissue Compared to That in Benign Prostate Hyperplasia Tissue (2016)

This corrects the article "Increased Expression of Herpes Virus-Encoded hsv1-miR-H18 and hsv2-miR-H9-5p in Cancer-Containing Prostate Tissue Compared to That in Benign Prostate Hyperplasia Tissue" on page 122.
Gigagon: a Monocentric Lens Design Imaging 40 Gigapixels (2010)

The Gigagon is a f/2.5 five element monocentric lens resolving under 2 arcsec over a 120 degree field of view intended to image onto megapixel sensors tiled over the focal surface.