gebhart/patrepeval huggingface dataset:
Improvement of CD variation control for attenuated phase-shift mask (2007)

As the required accuracy of the mask arises, Cr shading film thickness has been thinner gradually. CD linearity with the thinner Cr film thickness has better performance. However, it is difficult to apply thinner Cr film thickness simply under the condition of OD > 3, which is needed for wafer printing. So, we tried to develop new shading film. We adopted MoSi film, because MoSi film has almost no micro loading effect compared with Cr film. MoSi shading film with att.PSM satisfied OD > 3 at 193nm wavelength with good resist profile. But the issue was dry-etching selectivity, because shading layer material was the same of att. PSM layer material. Therefore super thin Cr etching stopper was inserted between MoSi shading layer and MoSi att.PSM layer. The mask CD performance of new blank was evaluated for CD linearity, CD through pitch, and global loading effect. This blank and mask process reduce loading effect, therefore the mask CD performance is improved remarkably. In conclusion, the mask manufacturing process margin was able to be expanded by this new blank and method, and it is expected that we can achieve the required specifications for att.PSM in 45nm node and beyond.
Development of a Web-Enabled SVR-Based Machine Learning Platform and its Application on Modeling Transgene Expression Activity of Aminoglycoside-Derived Polycations (2017)

SOLE has a user-friendly interface and includes routine elements of performing QSAR/QSPR studies that can be applied in various research areas. It utilizes rational and sophisticated feature selection, model selection and model evaluation processes.
An efficient message passing decoding algorithm for raptor codes on hand-held consumer electronics (2010)

This paper proposes a new decoding algorithm for raptor codes which are widely used rateless channel codes in the area of multimedia broadcast services such as 3GPP MBMS, DVB-H etc. The decoding algorithms for raptor codes can be categorized into two groups. One is the Maximum Likelihood (ML) decoding which shows good performance with very high computational complexity. The other is the Message Passing (MP) decoding with very low computational complexity but the performance is very poor. In this paper, we propose a modified MP decoding which can achieves much better performance with a little increase of complexity compared to the conventional MP decoding.
Simulateur multiagent d'un réseau de création de valeur : application à l'industrie forestière (2010)

Les décisions de planification à l'intérieur d'un réseau de création de valeur sont multiples et peuvent entraîner de lourdes conséquences pour une entreprise. Différents outils sont disponibles pour aider les personnes en charge de prendre ces décisions en offrant un suivi sur la production, le transport, les inventaires, etc. Ce mémoire propose la conception d'un simulateur basé sur une plateforme dc planification multiagent déjà existante. Pour se faire, différents mécanismes de simulation devront être implantés, principalement la gestion du temps. De plus, un nouvel agent a été développé afin de simuler le rôle de clients dans un réseau de création de valeur de bois d'oeuvre. De plus, cet agent permet dc simuler les deux types dc relation d'affaires qui sont les plus courantes dans cette industrie. La dernière contribution est la conception d'un cas d'étude pour démontrer les capacités dc ce simulateur à travers différentes expérimentations.
Short circuit of a high voltage high current MOSFET MATRIX Switch (2000)

International audience
Effect of composition and oxygen content on the microwave properties of evaporated Y-Ba-Cu-O thin films (1995)

Thin films of YBa/sub 2/Cu/sub 3/O/sub 7-x/ have been grown by electron beam evaporation of the metals in the presence of atomic oxygen, with small systematic variations in cation composition. Films grown close to the stoichiometric composition or with excess yttrium are smooth while those with excess barium are substantially rougher. The effect of these differences in cation composition on both microwave and dc properties is dominated by the associated large changes in film morphology. This determines the oxygenation state, and hence the electrical properties, of the superconductor both in the as-grown state and after annealing in a furnace or with atomic oxygen. For all films a strong correlation is found between penetration depth, resistivity and c-lattice parameter which all decrease with increasing oxygen content. In our standard growth regime and at higher oxygen contents the films are overdoped and T/sub c/ falls with increasing oxygen content.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Erratum to: Study of the spin and parity of the Higgs boson in diboson decays with the ATLAS detector (2016)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
A Intersecção Direito – Psicanálise (2007)

O artigo apresenta a investigação que a Antena do Campo Freudiano e o Centro de Estudos de Psicanálise efectuam juntamente com o «Núcleo Direito e Psicanálise» da Universidade Federal do Paraná (Brasil), faz um histórico da situação e introduz ao problema lógico da «Intersecção Direito – Psicanálise».
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins (2010)

Integrins are ubiquitous transmembrane mechanoreceptors that elicit changes in intracellular biochemistry in response to mechanical force application, but these alterations generally proceed over seconds to minutes. Stress-sensitive ion channels represent another class of mechanoreceptors that are activated much more rapidly (within msec), and recent findings suggest that calcium influx through Transient Receptor Potential Vanilloid-4 (TRPV4) channels expressed in the plasma membrane of bovine capillary endothelial cells is required for mechanical strain-induced changes in focal adhesion assembly, cell orientation and directional migration. However, whether mechanically stretching a cell's extracellular matrix (ECM) adhesions might directly activate cell surface ion channels remains unknown. Here we show that forces applied to beta1 integrins result in ultra-rapid (within 4 msec) activation of calcium influx through TRPV4 channels. The TRPV4 channels were specifically activated by mechanical strain in the cytoskeletal backbone of the focal adhesion, and not by deformation of the lipid bilayer or submembranous cortical cytoskeleton alone. This early-immediate calcium signaling response required the distal region of the beta1 integrin cytoplasmic tail that contains a binding site for the integrin-associated transmembrane CD98 protein, and external force application to CD98 within focal adhesions activated the same ultra-rapid calcium signaling response. Local direct strain-dependent activation of TRPV4 channels mediated by force transfer from integrins and CD98 may therefore enable compartmentalization of calcium signaling within focal adhesions that is critical for mechanical control of many cell behaviors that underlie cell and tissue development.
Retinoid signaling pathway protein alterations in patients with amyotrophic lateral sclerosis (2009)

The mechanisms underlying the motor neuron (MN) degeneration that occurs with amyotrophic lateral sclerosis (ALS) are poorly understood. Multiple studies have described the differential expression of retinoid signaling components in ALS patients and transgenic animal models. We investigated this pathway in human lumbar spinal cord tissue of patients with sporadic (SALS) and familial (FALS) ALS as well as controls with immunohistochemistry, immunoblotting, co‐immunoprecipitation and DNA‐binding assays. In SALS MNs, cellular retinoic acid binding protein (CRABP)‐II, the protein responsible for facilitating nuclear receptor interactions, was concentrated to the nucleus while FALS and control MNs had a diffuse cytoplasmic pattern. Nuclear retinoic acid receptor (RAR) βexhibited increased immunoreactivity in MN nuclei of individuals with SALS although both controls and individuals with FALS lacked this nuclear immunostaining. For MNs with RARβ nuclear staining, activated caspase‐3 was negative. Our results indicate that retinoid signaling is altered in ALS. Differences with respect to RARβ suggest that retinoid signaling impacts only SALS and that this is a pro‐survival response. Research Support: NIH grant ES013469 (RB); NIH T32 EB001026 (CK); NIH T32 05 TL1 RR024155‐02 (CK)
Combined expression of glucokinase and invertase in potato tubers leads to a dramatic reduction in starch accumulation and a stimulation of glycolysis (1998)

The original aim of this work was to increase starch accumulation in potato tubers by enhancing their capacity to metabolise sucrose.We previously reported that specific expression of a yeast invertase in the cytosol of tubers led to a 95% reduction in sucrose content, but that this was accompanied by a larger accumulation of glucose and a reduction in starch. In the present paper we introduced a bacterial glucokinase from Zymomonas mobilis into an invertase-expressing transgenic line, with the intention of bringing the glucose into metabolism. Transgenic lines were obtained with up to threefold more glucokinase activity than in the parent invertase line and which did not accumulate glucose. Unexpectedly, there was a further dramatic reduction in starch content, down to 35% of wild-type levels. Biochemical analysis of growing tuber tissue revealed large increases in the metabolic intermediates of glycolysis, organic acids and amino acids,two- to threefold increases in the maximum catalytic activities of key enzymes in the respiratory pathways, and three- to fivefold increases in carbon dioxide production.These changes occur in the lines expressing invertase,and are accentuated following introduction of the second transgene, glucokinase. We conclude that the expression of invertase in potato tubers leads to an increased flux through the glycolytic pathway at the expense of starch synthesis and that heterologous overexpression of glucokinase enhances this change in partitioning.
Localization in internets of mobile agents: A linear approach (2018)

Fifth generation~(5G) networks providing much higher bandwidth and faster data rates will allow connecting vast number of static and mobile devices, sensors, agents, users, machines, and vehicles, supporting Internet-of-Things (IoT), real-time dynamic networks of mobile things. Positioning and location awareness will become increasingly important, enabling deployment of new services and contributing to significantly improving the overall performance of the 5G~system. Many of the currently talked about solutions to positioning in~5G are centralized, mostly requiring direct line-of-sight (LoS) to deployed access nodes or anchors at the same time, which in turn requires high-density deployments of anchors. But these LoS and centralized positioning solutions may become unwieldy as the number of users and devices continues to grow without limit in sight. As an alternative to the centralized solutions, this paper discusses distributed localization in a 5G enabled IoT environment where many low power devices, users, or agents are to locate themselves without global or LoS access to anchors. Even though positioning is essentially a non-linear problem (solving circle equations by trilateration or triangulation), we discuss a cooperative \textit{linear} distributed iterative solution with only local measurements, communication and computation needed at each agent. Linearity is obtained by reparametrization of the agent location through barycentric coordinate representations based on local neighborhood geometry that may be computed in terms of certain Cayley-Menger determinants involving relative local inter-agent distance measurements.
Supplementary Tables 1-3 from Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer (2023)

Supplementary Tables 1-3 from Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer
Thermally controlled vanadium dioxide thin film microwave devices (2013)

Vanadium dioxide (VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) thin films have unique insulator to metal transition above the critical temperature of 68 °C. In this study, VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin films were deposited on a sapphire substrate for thermally controllable RF/microwave devices such as switches, limiters and resonators. The selectively deposited VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin film based devices showed ~2 kΩ at room temperature and less than 2 Ω at 70 °C. These thermally controlled varistors were utilized in shunt as well as series configurations for microwave switching and in resonant structures. Switching devices designed using a VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> shunt varistor showed good isolation (>20 dB) and low insertion loss (<;1 dB) up to 20 GHz. This paper presents two types of shunt varistor devices designed and fabricated on sapphire substrates.
Abstract 5099: Evaluating Ago2 as an oncogene in Kras-dependent lung carcinoma (2018)

Abstract Background: Lung cancer is the deadliest malignancy in the United States. Non-small cell lung cancer (NSCLC) accounts for 85% of cases, and is frequently driven by activating mutations in the gene encoding the KRAS GTPase (e.g. KRASG12D). Our previous work demonstrated that Argonaute 2 (AGO2)—a component of the RNA induced silencing complex (RISC)—physically interacts with KRAS and stabilizes it at the protein level. In NSCLC cell lines, AGO2 knockdown reduces KRAS protein level and attenuates cell proliferation. We hypothesized that AGO2 acts as an oncogene in KRASG12D-dependent NSCLC in vivo. Methods: To test the hypothesis, we generated a NSCLC model by intercrossing mice harboring a stop-floxed KRASG12D allele with animals containing a tamoxifen-responsive Cre recombinase gene driven by the (clara cell-specific) CCSP promoter. These animals, which frequently die within 10 weeks of tamoxifen treatment, display pulmonary lesions including hyperplasia, adenoma and frank adenocarcinoma. We evaluated whether concomitant ablation of one or both copies of (floxed) AGO2 influenced the NSCLC phenotype. After tamoxifen administration, we monitored mice daily and harvested tissues when mice were clinically moribund or reached 16 weeks of post-treatment. We harvested lungs for gross/ pathological examination and gene/ protein expression analysis. Results: While pathologically discernable adenocarcinoma was detectable in AGO2+/+ and AGO2f/+ animals, AGO2f/f mice were free of these lesions. Despite this, deletion of AGO2 had no impact on frequency or extent of hyperplastic or adenomatous lesions. Immunohistochemistry demonstrated absence of AGO2 in tumor tissue of AGO2f/f mice. Conclusion: AGO2 promotes progression but not initiation of cancerous lesions in a mouse model of KRASG12D-dependent NSCLC. Citation Format: Andrew E. Goodrum, Lisha Wang, Alice Xu, Kristin M. Juckette, Arul M. Chinnaiyan, Jean C. Tien. Evaluating Ago2 as an oncogene in Kras-dependent lung carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5099.
An Empirical Study of Human Behavioral Agents in Bandits, Contextual Bandits and Reinforcement Learning (2020)

Artificial behavioral agents are often evaluated based on their consistent behaviors and performance to take sequential actions in an environment to maximize some notion of cumulative reward. However, human decision making in real life usually involves different strategies and behavioral trajectories that lead to the same empirical outcome. Motivated by clinical literature of a wide range of neurological and psychiatric disorders , we propose here a more general and flexible parametric framework for sequential decision making that involves a two-stream reward processing mechanism. We demonstrated that this framework is flexible and unified enough to incorporate a family of problems spanning multi-armed bandits (MAB), contextual bandits (CB) and reinforcement learning (RL), which decompose the sequential decision making process in different levels. Inspired by the known reward processing abnormalities of many mental disorders, our clinically-inspired agents demonstrated interesting behavioral trajectories and comparable performance on simulated tasks with particular reward distributions, a real-world dataset capturing human decision-making in gambling tasks, and the PacMan game across different reward stationarities in a lifelong learning setting.
Hybrid Si-SiC fast switching cell modelling and characterisation including parasitic environment description by PEEC method (2003)

Silicon carbide (SiC) Schottky rectifiers are now available for high voltage (600 V and above). They allow major improvement in power converter efficiency compared with the state-of-the-art of silicon bipolar. In association with latest fast MOSFET in hybrid switching cell (Si MOSFET + SiC diode), switching losses can be dramatically decreased by switching speed improvement. Then, due to high switching speed, the parasitic effects must be taken into account if an accurate description of the cell is needed. Even if intrinsic performances of the new MOSFET are very good (among others, low charges or superjunction technologies), paralleled capacitors and serial inductances of the cell environment limit the practical switching speed. The aim of this work is to propose an accurate model of this new switching cell. This model will be implemented in a temporal simulator in order to give predictive waveforms in losses and EMI investigations in power factor correction. A complete model of the switching cell is presented, which includes intrinsic characteristics of semiconductor with nonlinear capacitance in diode and MOSFET model. Parasitic behaviours are also taken into account with the PEEC method. Experiment and simulation results are compared and they show that accurate waveforms are obtained even in high switching speed.
Expression levels of transdominant peptides and proteins in Saccharomyces cerevisiae (2001)

From libraries of peptides and protein fragments, several inhibitors that block pheromone response in Saccharomyces cerevisiae have been isolated previously. In many cases, the inhibitors are displayed as part of a scaffold, such as green fluorescent protein. Each of the inhibitors has a characteristic physiological strength or genetic penetrance. In this report, the roles of expression level and display scaffold on the activities of a subset of pheromone-response pathway inhibitors were examined. Special consideration was given to the relationship between expression levels of specific inhibitors, which may exceed 50 microM in some instances, and penetrance.
Effect of the average soft‐segment length on the morphology and properties of segmented polyurethane nanocomposites (2006)

Abstract Two organically modified layered silicates (with small and large diameters) were incorporated into three segmented polyurethanes with various degrees of microphase separation. Microphase separation increased with the molecular weight of the poly(hexamethylene oxide) soft segment. The molecular weight of the soft segment did not influence the amount of polyurethane intercalating the interlayer spacing. Small‐angle neutron scattering and differential scanning calorimetry data indicated that the layered silicates did not affect the microphase morphology of any host polymer, regardless of the particle diameter. The stiffness enhancement on filler addition increased as the microphase separation of the polyurethane decreased, presumably because a greater number of urethane linkages were available to interact with the filler. For comparison, the small nanofiller was introduced into a polyurethane with a poly(tetramethylene oxide) soft segment, and a significant increase in the tensile strength and a sharper upturn in the stress–strain curve resulted. No such improvement occurred in the host polymers with poly(hexamethylene oxide) soft segments. It is proposed that the nanocomposite containing the more hydrophilic and mobile poly(tetramethylene oxide) soft segment is capable of greater secondary bonding between the polyurethane chains and the organosilicate surface, resulting in improved stress transfer to the filler and reduced molecular slippage. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 128–139, 2006
Comparison of the Retro Screw and Standard Interference Screw for ACL Reconstruction (2012)

The objective of the study was to compare the load to failure between a retro screw (RS) and a standard interference screw (IS) for tibial-sided anterior cruciate ligament (ACL) fixation. We used 20 bovine tibia and extensor tendons for the study. A group of 10 specimens underwent IS fixation while the other 10 underwent RS fixation. Within each group, five specimens had graft suture in contact (interdigitating) with the screw threads. All specimens were tested on the MTS 858 Mini Bionix II (MTS Systems, Shakopee, MN). There was no statistically significant difference between the RS and IS with respect to peak load to failure. IS with suture interdigitation failed at an average of 520 N (range: 358 to 793 N), while the RS with suture interdigitation failed at 613 N (range: 438 to 1089 N). The IS without suture interdigitation failed at 654 N and the RS without suture interdigitation at 531 N. Specimens with a whipstitch in contact with the screw did not demonstrate higher pull out strength. The RS fixation strength appears to equal the IS. Graft suture contact with screw threads does not increase fixation strength. Based on this study, using a RS for tibial ACL soft tissue graft fixation is feasible and provides equal fixation strength compared with the standard IS.
Evaluation of Aperture Codes for High Throughput Spectroscopy (2006)

A coded aperture spectrometer maintains the spectral resolution of a traditional slit spectrometer while dramatically increasing the throughput. Here we evaluate the performance of different aperture codes for spectroscopy of weak, incoherent sources.