gebhart/patrepeval huggingface dataset:
Conversion of Enediynes into Quinones by Antibody Catalysis and in Aqueous Buffers:  Implications for an Alternative Enediyne Therapeutic Mechanism (2001)

International audience
Generation of induced pluripotent stem cell GZLSL-i001-A derived from urine-derived cells of Hemophilia A patient with Inv22 mutation (2020)

Hemophilia A (HA), is a X-linked recessive congenital bleeding disorder, caused by deficiency of the coagulation factorVIII (FVIII) which is encoded by coagulation factor 8 (F8). HA affects 1 of every 5,000 males worldwide. The intron 22 inversion (Inv22) mutation of F8 causes about 45% of severeHA cases.Here, we generated induced pluripotent stem cells (iPSCs) from a HA patient with Inv22 mutation by electroporation of urine-derived cells (UCs) with episomal plasmids under feeder-free, virus-free, serum-free condition and without oncogene c-MYC. This iPSCs line could facilitate future applications of human iPSCs by provide a valuable cell model.
Random access protocol for massive MIMO: Strongest-user collision resolution (SUCR) (2016)

Wireless networks with many antennas at the base stations and multiplexing of many users, known as Massive MIMO systems, are key to handle the rapid growth of data traffic. As the number of users increases, the random access in contemporary networks will be flooded by user collisions. In this paper, we propose a reengineered random access protocol, coined strongest-user collision resolution (SUCR). It exploits the channel hardening feature of Massive MIMO channels to enable each user to detect collisions, determine how strong the contenders' channels are, and only keep transmitting if it has the strongest channel gain. The proposed SUCR protocol can quickly and distributively resolve the vast majority of all pilot collisions.
THE DIFFERENTIAL ROLE OF CD28-B7 VERSUS CD40L-CD40 IN REGULATING ALLOIMMUNE RESPONSES IN STAT 4 VERSUS STAT 6 GENE KNOCKOUT MICE. (2000)

Dong, Victor M.1; Kishimoto, Koji1; Exeni, Andrea2; Yamada, Akira3; Waaga, Ana Maria1; Briscoe, David M.2; Auchincloss, Hugh3; Grusby, Michael J.4; Khoury, Samia J.1; Sayegh, Mohamed H.1 Author Information
94.6% peak efficiency DCM buck converter with fast adaptive dead-time control (2013)

This paper presents a dynamic logic based adaptive dead-time control circuit (DADTC) for fast and adaptive control to minimize body diode conduction losses and dead-time of the buck regulator operating in discontinuous conduction mode (DCM). Dead-time is an important metric for improving efficiency of low voltage converters. DADTC provides instant sensing and feedback based on the load to minimize dead-time significantly compared to prior art and enables higher overall power efficiency of the converter. Further, the presented buck converter has inherent pulse skipping mode to lower the switching frequency at light loads further enhancing light load efficiency. The buck regulator was fabricated in 0.35 μm CMOS process with an input voltage range of 1.8V-3V and load current range of 1mA-200mA. Measurement results show that the proposed design achieves peak power efficiency of 94.6% and a high overall power efficiency ( > ~89%) for load currents greater than 5mA with a sensing delay of only ~5ns for V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IN</sub> = 1.8V.
Near-Field and Far-Field Expansions for Traveling-Wave Circular Loop Antennas - Abstract (2000)

Convenient closed-form far-field expressions for thin circular loop antennas which possess a traveling-wave current distribution have been available for many years. However, a method for analytically evaluating the more complicated near-zone vector potential and corresponding electromagnetic field integrals associated with traveling-wave circular loop antennas has not been previously reported in the electromagnetics literature. The purpose of this paper is to introduce a systematic approach for finding exact series representations of these integrals which are valid not only in the far-field of the loop, but also in its near-field region. These mathematically exact solutions are general and can be shown to contain all of the well-known classical approximations as special cases.
Entrainment and chaos in a respiratory neural network model with oscillatory input (2005)

We study the dynamical behavior of a respiratory central pattern generator (CPG) model under oscillatory inputs. To characterize the physiological role of oscillatory input in a realistic CPG system, we chose a model with a minimal number of respiratory neurons which generates a stable oscillation for oscillatory or constant input. We simulated the system using sinusoidal waves with various amplitudes, frequencies, and relative phases. We also studied the critical number of inputs for entrainment to occur. The results suggested that for normal physiological oscillations, inspiratory and expiratory neurons should receive anti-phase oscillatory input. We also found various oscillation patterns including chaotic oscillations induced by the CPG under in-phase oscillatory input to the inspiratory and expiratory neurons.
Tumor Clustering and Gene Selection Techniques - A Survey (2012)

Cancer classification has become one of the active areas of research in the field of medical sciences. Various gene selection and tumor classification techniques have been available in the literature. Gene selection comprises of an exploration for gene subsets that are capable to discriminate tumor tissue from normal tissue. Gene selection is a primary issue in gene expression based tumor classification. Recently, Tissue microarrays have become an extensively used technique to screen for protein expression patterns in a large numbers of tumors. There is increasing interest in transforming the importance of tumor classification from morphologic to molecular. Gene expression profiles provide additional data when compared with morphology and offer a substitute to morphology-based tumor classification systems. So, researchers are very much intentional to develop novel approaches for gene selection and tumor classification. This paper provides a detailed related survey of various gene selection techniques and tumor classification approaches.
A compressible pressure-based finite-volume method for homogenous two-phase mixtures including multiple gas species (2012)

A compressible multi-phase flow solver has been developed with the goal of simulating naval hydrodynamics problems associated with underwater explosions (UNDEX) and gas-launched projectiles and missiles. The formulation utilizes a pressure-based PISO-type finite-volume algorithm for two-phase mixtures, including multiple gas species, and is implemented using the OpenFOAM CFD Toolbox. A volume-of-fluid (VOF) approach is used to model the fluid-fluid interfaces, and we adopt an isentropic ideal-gas equation-of-state for the gas phase and assume a constant speed-of-sound in the liquid phase. Since we are interested in applications where more than one gaseous species can be present, we introduce mass-balance equations which enable the tracking of each species. In the ICNMMF presentation, we will review the derivation of the mathematical model and the implementation using the OpenFOAM libraries. We will present results from basic test cases and UNDEX applications. For example, Figure 1 shows pressure contours at time = 1.1ms from an UNDEX simulation under a flat plate. Comparison to Kadioglu and Sussman (2008) show that our solver is predicting similar results to their high-fidelity nested-mesh approach. Figure 2 shows an UNDEX simulation near an ocean air-water interface, and demonstrates three- dimensional simulation of a multi-species problem where the gas phase consists of air and UNDEX gas. In addition, the simulation demonstrates the ability to model the large-scale free- surface disturbance caused by the violent underwater bubble growth-and-collapse process. To conclude the presentation, we will summarize some of the key challenges in the mathematical and numerical formulation of our solver, and provide ideas on resolving these issues in future work.
Bis(oxazoline)×Copper(I)‐Catalyzed Enantioselective Cyclopropanation of Cinnamate Esters with Diazomethane. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias (2009)

This study shows the hypermethylation profile of RASSF genes in leukaemias is distinct from that of solid tumours and represents the first report of inactivation of RASSF6 or RASSF10 in cancer. These data show epigenetic inactivation of the candidate TSGs RASSF6 and RASSF10 is an extremely frequent event in the pathogenesis of childhood leukaemia. This study also warrants further investigation of the newly identified RASSF member RASSF10 and its potential role in leukaemia.
Deep-Learning Based Adaptive Ultrasound Imaging from Sub-Nyquist Channel Data (2020)

Traditional beamforming of medical ultrasound images relies on sampling rates significantly higher than the actual Nyquist rate of the received signals. This results in large amounts of data to store and process, imposing hardware and software challenges on the development of ultrasound machinery and algorithms, and impacting the resulting performance. In light of the capabilities demonstrated by deep learning methods over the past years across a variety of fields, including medical imaging, it is natural to consider their ability to recover high-quality ultrasound images from partial data. Here, we propose an approach for deep-learning based reconstruction of B-mode images from temporally and spatially sub-sampled channel data. We begin by considering sub-Nyquist sampled data, time-aligned in the frequency domain and transformed back to the time domain. The data is further sampled spatially, so that only a subset of the received signals is acquired. The partial data is used to train an encoder-decoder convolutional neural network, using as targets minimum-variance (MV) beamformed signals that were generated from the original, fully-sampled data. Our approach yields high-quality B-mode images, with higher resolution than previously proposed reconstruction approaches (NESTA) from compressed data as well as delay-and-sum beamforming (DAS) of the fully-sampled data. In terms of contrast to noise ratio, our results are comparable to MV beamforming of the fully-sampled data, thus enabling better and more efficient imaging than is mostly used in clinical practice today.
Metallization on Poly(tetrafluoroethylene) Substrate by Excimer-Laser-Induced Surface Reaction and Chemical Plating (1998)

Surface of poly(tetrafluoroethylene) [PTFE] film was modified chemically by an ArF excimer laser-induced reaction in a hydrazine gas atmosphere. The polymer surface defluorinated with the photolyzed hydrazine showed hydrophilicity high enough to be metallized by chemical plating. The mechanism for the modification was investigated by XPS, FTIR, and SIMS analyses. A patterned nickel plating having a sufficient adhesion strength was carried out by the area-selective laser-treatment. This processing provides a fullyadditive method for fabrication of printed wiring boards with PTFE substrates.
Characterization of Material With Epidermal Growth Factor Immunoreactivity in Human Serum and Platelets* (1989)

We investigated the molecular nature of the epidermal growth factor immunoreactivity (ir-EGF) in serum and platelets of normal subjects. In serum, ir-EGF appeared and increased during spontaneous blood coagulation, reaching a plateau in 2 h. The mean plateau measured by time-resolved immunofluorometric assay was 778 pg/mL [130 pmol/L; range, 465-1352 pg/mL (78-225 pmol/L)] for men (n = 66), and 774 pg/mL (129 pmoL/L; range, 521-1114 pg/mL (87-186 pmol/L)] for women (n = 33). Serum samples (n = 9), when examined under nonreducing conditions by high performance liquid chromatography, contained three mol wt components. Their approximate proportions averaged 56 +/- 6% (+/- SD) for a 140K component, 22 +/- 9% for a 67K component, and 22 +/- 6% for a component coeluting with the 6K EGF standard. The molecular size distribution of ir-EGF released from isolated platelets varied with the treatment of the platelets. After stimulation with a Ca2+ ionophore, the proportions of the 140K, 67K, and 6K components were 61 +/- 11%, 20 +/- 8%, and 17 +/- 4% (n = 5), respectively, as in serum. In addition, we found a small amount, (approximately 1%) of a 17K component. When platelets (n = 6) were ruptured by sonication and repeated freeze-thawing, the 67K component formed 53 +/- 7% of the total; the proportions of the 140K, 17K, and 6K components were 14 +/- 7%, 2.1 +/- 0.7%, and 31 +/- 4%, respectively. Under reducing conditions the 17K and 6K components remained intact, but part of the 140K component and all of the 67K component were cleaved to a 35-37K form. After protease digestion of the higher mol wt components, the ir-EGF was exclusively of the 6K form. The 67K and 6K components bound to the EGF receptor, whereas the 140K component bound inconsistently. We conclude that treatment of platelets with Ca2+ ionophore produces ir-EGF components similar to those found in incubated serum but different from those obtained by freeze-thawing. The 67K mol wt component appears to be the main storage form of EGF in platelets; at least two independent mechanisms appear to exist for EGF release.
Mildew Remover for Aircraft Applications (2005)

A patented uninhibited mildew remover was developed at the Naval Air Depot, Cherry Point, North Carolina. This mildew remover passed most of the critical performance tests found in the Navy and Army's cleaner specifications MIL-PRF-885570D and ADS-61A-PRF-2002, except for the titanium total immersion corrosion and sandwich corrosion tests. A new corrosion-inhibiting version of this remover was developed which passed all of the critical test requirements. Cleaning efficiency test results were satisfactory for both the uninhibited and new corrosion-inhibiting formulations.
Electrophysiology-Guided Genetic Characterisation Maximises Molecular Diagnosis in an Irish Paediatric Inherited Retinal Degeneration Population (2022)

Inherited retinal degenerations (IRDs) account for over one third of the underlying causes of blindness in the paediatric population. Patients with IRDs often experience long delays prior to reaching a definitive diagnosis. Children attending a tertiary care paediatric ophthalmology department with phenotypic (i.e., clinical and/or electrophysiologic) evidence suggestive of IRD were contacted for genetic testing during the SARS-CoV-2-19 pandemic using a "telegenetics" approach. Genetic testing approach was panel-based next generation sequencing (351 genes) via a commercial laboratory (Blueprint Genetics, Helsinki, Finland). Of 70 patient samples from 57 pedigrees undergoing genetic testing, a causative genetic variant(s) was detected for 60 patients (85.7%) from 47 (82.5%) pedigrees. Of the 60 genetically resolved IRD patients, 5% (<i>n</i> = 3) are eligible for approved therapies (<i>RPE65</i>) and 38.3% (<i>n</i> = 23) are eligible for clinical trial-based gene therapies including <i>CEP290</i> (<i>n</i> = 2), <i>CNGA3</i> (<i>n</i> = 3), <i>CNGB3</i> (<i>n</i> = 6), <i>RPGR</i> (<i>n</i> = 5) and <i>RS1</i> (<i>n</i> = 7). The early introduction of genetic testing in the diagnostic/care pathway for children with IRDs is critical for genetic counselling of these families prior to upcoming gene therapy trials. Herein, we describe the pathway used, the clinical and genetic findings, and the therapeutic implications of the first systematic coordinated round of genetic testing of a paediatric IRD cohort in Ireland.
Macromolecular Engineering and Additive Manufacturing of Poly(styrene-b-isobutylene-b-styrene) (2021)

Although polyisobutylene (PIB)-based thermoplastic elastomers (TPEs) possess a combination of unique properties (i.e., low permeability, high environmental and chemical stability, and excellent biocompatibility), they have not been explored for 3D printing. Poly(styrene-b-isobutylene-b-styrene) (SIBS) is one of the most important PIB-based TPEs used in biomedical applications. Herein, we report, for the first time, the development of an efficient and low-cost 3D printing strategy of SIBS by fine-tuning its microstructure and properties. We discovered that blending the polystyrene (PS) homopolymer with SIBS leads to significant changes in its microphase-separated structure. The amount and molecular weight of the added PS significantly affect the micromorphology and 3D printability of SIBS/PS blends. In particular, SIBS/PS blends with high molecular weight PS at relatively high weight fractions show a unique hierarchical salami micromorphology with appropriate properties (improved hardness, modulus, and thermal stability) for 3D printing by fused filament fabrication. SIBS/PS blends with PS molecular weight close to or higher than that of SIBS show better printability than blends with low molecular weight PS. Blending the PIB block copolymer with the homopolymer of its hard block is an efficient and cost-effective strategy for additive manufacturing of PIB-based elastomers with widely tunable properties.
Uniform Amplification of Phage with Different Growth Characteristics in Individual Compartments Consisting of Monodisperse Droplets (2010)

Save every clone! In phage display, clones displaying ligands that hinder growth of phage are lost in amplification. Competition of slowly (S) and rapidly (R) growing phage is mitigated in monodisperse emulsions generated by a simple microfluidic device. Separating R and S in ca. 107 droplets maintains R/S ratio throughout amplification. Competition-free amplification of phage preserves ligands that are usually lost in phage display screen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Opinion Marks : A Human-Based Computation Approach to Instill Structure into Unstructured Text on the Web (2015)

Despite recent improvements in computational approaches such as<br />machine learning, natural language processing, and computational<br />linguistics, making a computer understand human-generated unstructured<br />text still remains a difficult problem to solve. To alleviate<br />the challenges, we propose an approach called “Opinion Marks,”<br />which enables writers to mark positive and negative aspects of a<br />topic on their own text. In addition, Opinion Marks incorporates an<br />automatic marking suggestion algorithm to offload a user’s marking<br />effort. The phrases marked with Opinion Marks can be further<br />used to clarify the sentiments of other text in a similar context.<br />We implemented Opinion Marks at a question answering website<br />http://caniask.net. To test the efficacy of Opinion Marks, we<br />conducted a crowdsourced experiment with 144 participants in a<br />between-subject design under three different conditions: 1) human<br />marking only; 2) machine marking only (automatic marking suggestion);<br />and 3) human-machine collaboration (Opinion Marks).<br />This study revealed that Opinion Marks significantly improves the<br />quality of marked phrases and usability of the system.
Double magnetic proximity in Fe/Fe0.32V0.68 superlattices (2018)

The conventional magnetic proximity effect and double-proximity effects were studied in a set of fully coherent high-quality Fe/${\mathrm{Fe}}_{0.32}{\mathrm{V}}_{0.68}$ superlattices. Applying a simple model to the saturation magnetization, it is seen that the magnetic proximity effect is gigantic in magnitude in the alloy---the magnetization is enhanced by 20--450 % and the ordering temperature is enhanced by a factor of 2. The magnitude of the effect can be explained by the large susceptibility of the alloy above its intrinsic ordering temperature. Additionally, a strong dependence of the ordering temperature of single monolayers of Fe on the interlayer distance is observed. The results give insight into new ways of using alloying and large magnetic susceptibility combined with magnetic proximity effects to enhance the functionality of materials that are of interest for spintronic devices.
Fusion Space Propulsion with a Field Reversed Configuration (1989)

The objective of this study is to examine a fusion space propulsion system using D-3He in a reversed field configuration (FRC). Such a configuration provides good confinement and high-β operation with high power densities in a compact design. The reversed field is maintained by a combination of fuel pellet injection and energetic fusion products which create an azimuthal plasma current. The shielding requirements for a design using D-3He are minimized, providing an attractive power to weight ratio. Thrust is achieved through the use of a magnetic nozzle, where propellant is mixed with cold plasma flowing along open field lines and the mixture is exhausted through the nozzle.
Fluoroscopy-guided removal of a bitten endotracheal tube in an adult sheep (2018)

Summary A 60 kg female white alpine sheep accidentally bit its endotracheal tube during the recovery phase after an experimental surgical intervention. The distal tube portion had slipped down the trachea and was no longer visible in the laryngeal opening. The distal tube part could be recovered rapidly under fluoroscopic guidance using endoscopic forceps. The remaining recovery time was uneventful and the animal was able to complete the study with no complications.
ChemInform Abstract: Synthesis, Characterization, and Catalytic Properties of Microporous MgVAPO‐5. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluation of fluorinated dissolution inhibitors for 157-nm lithography (2003)

Fluorinated diesters were synthesized and evaluated as dissolution inhibitors (DIs) for 157 nm lithography. The results of dissolution rate measurements, exposure studies, and etching experiments on blends of fluorinated polymers containing these dissolution inhibitors are reported. It was shown that the DIs effectively slow the dissolution rate of the matrix polymer, poly(hexafluorohydroxyisopropyl styrene) (PHFHIPS). Etching studies show that they enhance the plasma etch resistance of poly(methyl methacrylate) using tetrafluoromethane plasma. Addition of the best performing dissolution inhibitor, cyclohexane-1,4-dicarboxylic acid bis-(1-cyclohexyl-2,2,2-trifluoro-1-methyl-ethyl) ester) (<b>FCDE1</b>) to candidate 157 nm photoresist polymers, Duvcor and poly(hexafluorohydroxyisopropyl styrene)-<i>co</i>-poly(t-butyl methacrylate) [pPHFHIPS-<i>co</i>-p<i>t</i>-BMA], improves the imaging behavior of these polymers. Our attempts to elucidate the mechanism of dissolution inhibition for this series of compounds will be discussed. Fourier Transform Infrared (FTIR) studies in conjunction with dissolution rate measurements performed on a series of DI analogues suggest a mechanism based on hydrogen bonding.