gebhart/patrepeval huggingface dataset:
Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial. (2008)

CF101 administered bid for 12 weeks resulted in improvement in signs and symptoms of RA that did not achieve statistical significance, and was safe and well tolerated. The expression level of A3AR was directly correlated with patient responses to CF101, suggesting its utilization as a biomarker for the pharmacodynamic and therapeutic effects of this novel agent. These findings require confirmation in a double-blind randomized placebo-controlled trial, currently under way.
Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages (2014)

Mycobacterium tuberculosis H37Rv, constitutively expressing a second copy of the transcriptional regulator DosR (Rv3133c) under control of the hsp60 promoter, was compared to wild-type M. tuberculosis for in vitro expression of the target genes of the DosR dormancy regulon, for its in vitro growth characteristics in liquid 7H9 culture medium, and for its capacity to replicate in murine macrophages. Under aerobic conditions, hsp60-driven DosR significantly induced the expression of 39 out of 44 DosR regulon genes, as assessed by real time qPCR. Increased DosR regulon gene transcription in vitro did not modify the capacity of the strain to grow under axenic conditions nor to infect murine macrophages as compared to unmodified wild-type bacteria.
Passive Switched Capacitor RF Front Ends for Spectrum Sensing in Cognitive Radios (2014)

This paper explores passive switched capacitor based RF receiver front ends for spectrum sensing. Wideband spectrum sensors remain the most challenging block in the software defined radio hardware design. The use of passive switched capacitors provides a very low power signal conditioning front end that enables parallel digitization and software control and cognitive capabilities in the digital domain. In this paper, existing architectures are reviewed followed by a discussion of high speed passive switched capacitor designs. A passive analog FFT front end design is presented as an example analog conditioning circuit. Design methodology, modeling, and optimization techniques are outlined. Measurements are presented demonstrating a 5 GHz broadband front end that consumes only 4 mW power.
Exsanguination Shock: The Next Frontier in Prevention of Battlefield Mortality (2011)

Blackbourne, Lorne H. MD, FACS; Baer, David G. PhD; Cestero, Ramon F. MD, FACS; Inaba, Kenji MD, FRCSC, FACS; Rasmussen, Todd E. MD, FACS Author Information
Fault-Tolerant Perception for Automated Driving A Lightweight Monitoring\n Approach (2021)

While the most visible part of the safety verification process of automated\nvehicles concerns the planning and control system, it is often overlooked that\nsafety of the latter crucially depends on the fault-tolerance of the preceding\nenvironment perception. Modern perception systems feature complex and often\nmachine-learning-based components with various failure modes that can\njeopardize the overall safety. At the same time, a verification by for example\nredundant execution is not always feasible due to resource constraints. In this\npaper, we address the need for feasible and efficient perception monitors and\npropose a lightweight approach that helps to protect the integrity of the\nperception system while keeping the additional compute overhead minimal. In\ncontrast to existing solutions, the monitor is realized by a well-balanced\ncombination of sensor checks -- here using LiDAR information -- and\nplausibility checks on the object motion history. It is designed to detect\nrelevant errors in the distance and velocity of objects in the environment of\nthe automated vehicle. In conjunction with an appropriate planning system, such\na monitor can help to make safe automated driving feasible.\n
1921 Liquid Cooling Module for LSI Board Densely Mounted with Multi Channel Optical Interface (2007)

We have developed a cooling system for a 300W LSI surrounded by optical transmission modules, dissipating a total of 100W, for a next-generation high performance computer. The liquid cooling system is required to be not only highly effective but also compact because the optical modules need to be as close as possible to the LSI for high speed transmission. The coolant flows first through a single cooling pipe thermally attached to the numerous optical modules and then a cold plate with microscopic fins to cool the high power LSI.
Introduction to the Special Issue on the 2007 IEEE International Solid-State Circuits Conference (2008)

The 30 papers in this special issue were among those presented at the IEEE International Solid-State Circuits Conference (ISSCC), held in San Francisco, CA, February 11-15, 2007. There are four areas: Digital Papers; Memory Papers; Signal Processing Papers; and Technology Direction Papers.
Continuity and robustness of programs (2012)

Computer scientists have long believed that software is different from physical systems in one fundamental way: while the latter have continuous dynamics, the former do not. In this paper, we argue that notions of continuity from mathematical analysis are relevant and interesting even for software. First, we demonstrate that many everyday programs are continuous (i.e., arbitrarily small changes to their inputs only cause arbitrarily small changes to their outputs) or Lipschitz continuous (i.e., when their inputs change, their outputs change at most proportionally). Second, we give an mostly-automatic framework for verifying that a program is continuous or Lipschitz, showing that traditional, discrete approaches to proving programs correct can be extended to reason about these properties. An immediate application of our analysis is in reasoning about the robustness of programs that execute on uncertain inputs. In the longer run, it raises hopes for a toolkit for reasoning about programs that freely combines logical and analytical mathematics.
Vaccines and early breast cancer (2014)

"Vaccines and early breast cancer." Cell Cycle, 13(9), p. 1359Keywords:: breast cancerDCISCT genesER negativeThis article is related to:
Supplementary Video 8 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by <i>In Vivo</i> Microscopy and Single-Cell Pharmacodynamics (2023)

Supplementary Video 8 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by &lt;i&gt;In Vivo&lt;/i&gt; Microscopy and Single-Cell Pharmacodynamics
Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport (2015)

Organelles of the endolysosomal system undergo multiple fission and fusion events to combine sorting of selected proteins to the vacuole with endosomal recycling. This sorting requires a consecutive remodeling of the organelle surface in the course of endosomal maturation. Here we dissect the remodeling and fusion machinery on endosomes during the process of endocytosis. We traced selected GFP-tagged endosomal proteins relative to exogenously added fluorescently labeled α-factor on its way from the plasma membrane to the vacuole. Our data reveal that the machinery of endosomal fusion and ESCRT proteins has similar temporal localization on endosomes, whereas they precede the retromer cargo recognition complex. Neither deletion of retromer nor the fusion machinery with the vacuole affects this maturation process, although the kinetics seems to be delayed due to ESCRT deletion. Of importance, in strains lacking the active Rab7-like Ypt7 or the vacuolar SNARE fusion machinery, α-factor still proceeds to late endosomes with the same kinetics. This indicates that endosomal maturation is mainly controlled by the early endosomal fusion and remodeling machinery but not the downstream Rab Ypt7 or the SNARE machinery. Our data thus provide important further understanding of endosomal biogenesis in the context of cargo sorting.
Continuous flow cell trapping and hybridoma-cell production on-chip using "liquid electrodes" (2008)

This paper reports on a new microfluidic chip designed for cell electrofusion. A pair of cells is brought into close contact by means of opposite dielectrophoretic forces and they are subsequently fused by applying a short electrical pulse.
Multiplexed detection of cancer biomarkers using a microfluidic platform integrating single bead trapping and acoustic mixing techniques (2018)

It is critical to reliably and rapidly detect multiple disease biomarkers in tiny liquid samples with high sensitivity to meet the growing demand for point-of-care diagnostics. This paper reports a microfluidic platform integrating magnetic-based single bead trapping in conjunction with acoustic micromixing for simultaneous detection of multiple cancer biomarkers within minutes. Individual beads retained by permalloy (NiFe81/19) microarray were used to capture biomarkers and facilitate the fluorescence identification. A numerical study indicates that the magnetic force keeping a bead in the trap is proportional to the thickness of the permalloy array and the external magnetic field strength, while inversely proportional to the size of the trap. The acoustic microstreaming activated by a piezo transducer was applied to generate fast-switching flow patterns to minimize the diffusion length scales. The flow at various driving frequencies was experimentally tested to achieve the optimal mixing effect. The flow field of the microstreaming was subsequently described by a mathematical model to understand the flow further. Finally, the prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA) were employed as model analytes to demonstrate the capability of the platform for rapid biomarker detection. With the aid of acoustic micromixing, the detection can be finished in 20 minutes. The respective limit of detection of PSA and CEA is 0.028 ng mL-1 (0.8 pM) and 3.1 ng mL-1 (17 pM), which is respectively 1/142 and 1/3 of the cutoff value of PSA and CEA. Our results indicate this platform has great potential for the rapid detection of multiple biomarkers in future point-of-care diagnostics.
Spatially-enhanced clusterwise inference for testing and localizing intermodal correspondence (2022)

With the increasing availability of neuroimaging data from multiple modalities-each providing a different lens through which to study brain structure or function-new techniques for comparing, integrating, and interpreting information within and across modalities have emerged. Recent developments include hypothesis tests of associations between neuroimaging modalities, which can be used to determine the statistical significance of intermodal associations either throughout the entire brain or within anatomical subregions or functional networks. While these methods provide a crucial foundation for inference on intermodal relationships, they cannot be used to answer questions about where in the brain these associations are most pronounced. In this paper, we introduce a new method, called CLEAN-R, that can be used both to test intermodal correspondence throughout the brain and also to localize this correspondence. Our method involves first adjusting for the underlying spatial autocorrelation structure within each modality before aggregating information within small clusters to construct a map of enhanced test statistics. Using structural and functional magnetic resonance imaging data from a subsample of children and adolescents from the Philadelphia Neurodevelopmental Cohort, we conduct simulations and data analyses where we illustrate the high statistical power and nominal type I error levels of our method. By constructing an interpretable map of group-level correspondence using spatially-enhanced test statistics, our method offers insights beyond those provided by earlier methods.
Fabrication and characterization of gated field emitter arrays with self-aligned carbon nanotubes grown by chemical vapor deposition (2002)

Field emitter arrays with multiwall carbon nanotubes (CNTs) grown inside their gated holes were fabricated on glass substrates. The Fe–Ni–Co alloy catalyst dots on which the CNTs would be grown were deposited into the gated holes by a self-aligned method to maintain a constant distance between CNT emitters and gate electrodes. The CNTs were synthesized by thermal chemical vapor deposition using a gas mixture of CO and H2 at 500 °C. The CNT lengths were controlled by changing ratios of CO to H2. Field emission currents and images were monitored as a function of gate and anode voltages. It was shown that the CNT emitters grown just up to the gate electrode height operated best in a triode mode.
Mobility-Enhanced Device Technologies Using SiGe/Ge MOS Channels (2007)

Mobility enhancement technologies have currently been recognized as mandatory for future scaled MOSFETs. In this paper, we review our recent results on the development of mobility-enhanced CMOS device structures using strained-Si/SiGe/Ge MOS channels and the carrier transport properties in those channels. It is shown, particularly, that uniaxial compressive strain and Ge channels are quite effective in pMOS performance enhancement, while uniaxial tensile strain is effective in nMOS performance.
Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia (2022)

Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from brains with frontotemporal dementia due to GRN and MAPT mutations to identify the key cell types and molecular pathways in their pathophysiology. We compared patients with mutations in the GRN gene (n = 9) or with mutations in the MAPT gene (n = 13) with non-demented controls (n = 11). Using quantitative proteomic analysis on laser-dissected tissues we identified brain region-specific protein signatures for both genetic subtypes. Using published single cell RNA expression data resources we deduced the involvement of major brain cell types in driving these different protein signatures. Subsequent gene ontology analysis identified distinct genetic subtype- and cell type-specific biological processes. For the GRN subtype, we observed a distinct role for immune processes related to endothelial cells and for mitochondrial dysregulation in neurons. For the MAPT subtype, we observed distinct involvement of dysregulated RNA processing, oligodendrocyte dysfunction, and axonal impairments. Comparison with an in-house protein signature of Alzheimer's disease brains indicated that the observed alterations in RNA processing and oligodendrocyte function are distinct for the frontotemporal dementia MAPT subtype. Taken together, our results indicate the involvement of different brain cell types and biological mechanisms in genetic subtypes of frontotemporal dementia. Furthermore, we demonstrate that comparison of proteomic profiles of different disease entities can separate general neurodegenerative processes from disease-specific pathways, which may aid the development of disease subtype-specific treatment strategies.
Abstract A75: Serine auxotrophy: A novel metabolic vulnerability of platinum-resistant ovarian cancer? (2020)

Abstract Ovarian cancer accounts for the highest number of gynecologic-associated deaths in the developed world, and resistance to platinum-based therapy represents a major clinical and societal challenge in patients’ management. Since metabolism is intertwined with signaling pathways controlling cell death, we aimed to investigate to what extent metabolic adaptations could contribute to the development of the resistant phenotype. By performing isotope-labeled 13C-glucose tracer analysis in vitro, we found that, when they become resistant to platinum, ovarian cancer cells stop to synthetize serine and are characterized by significantly lower intracellular levels of this amino acid compared to sensitive cells. However, serine is required for cellular growth and survival, and resistant cells increase its uptake from the medium, becoming exquisitely vulnerable to serine starvation. We showed that, although resistant cells accumulate DNA damage upon platinum treatment, they have a higher capacity of repairing it because of increased poly(ADP)-ribose polymerase (PARP) activity, compared to the sensitive ones. Since PARP enzymes are major oxidized nicotinamide adenine dinucleotide (NAD+)-consuming enzymes, we collected evidence that serine synthesis downregulation, as a consequence of central carbon metabolic reshuffling, provides resistant cells with the advantage of sparing NAD+, thus sustaining PARP activation and allowing a more efficient DNA repair. We confirmed that downregulation of serine synthesis is a peculiar trait of resistant tumors also in vivo, using patient-derived xenografts (PDX) ovarian cancer models subjected to serine/glycine free diet. Moreover, analysis of The Cancer Genome Atlas Consortium (TCGA) ovarian cancer dataset revealed that tumors from platinum-resistant patients are characterized by a downregulation of serine biosynthetic enzymes, suggesting that serine auxotrophy could represent a novel and exploitable vulnerability of platinum-resistant ovarian cancers. Citation Format: Tom Van Nyen, Joao A.G. Duarte, Matteo Rossi, Mélanie Planque, Esther Zaal, Ali Talebi, Stijn Moens, Guy Eelen, Hugo Horlings, Johan Swinnen, Celia Berkers, Peter Carmeliet, Reuven Agami, Sarah-Maria Fendt, Diether Lambrechts, Daniela Annibali, Frederic Amant. Serine auxotrophy: A novel metabolic vulnerability of platinum-resistant ovarian cancer? [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research; 2019 Sep 13-16, 2019; Atlanta, GA. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(13_Suppl):Abstract nr A75.
Inhibition of gastric acid secretion by brain peptides in the dog (1986)

We have studied the effects of 30 peptides administered intracerebroventricularly on basal and pentagastrin-stimulated (8 pg/kg s.c.) gastric acid secretion in conscious dogs. None of the peptides significantly increased basal gastric acid secretion. Twelve peptides (2 nmollkg] significantly (p < 0.01) decreased the pentagastrin-stimulated 2-h acid output (percentage inhibition in parentheses): human calcitonin [CT) (36%], neurotensin (NT) (52%), rat corticotropin-releasing factor (CRF) (59%j, human calcitonin gene-related peptide (CGRP) (59%), ovine CRF (66%J, P-endorphin (P-End] (SO%], urotensin-I (81%), rat CT [81%), porcine gastrin-releasing peptide (GRP) (83%), sauvagine [Svg) (85%), rat CGRP (87%), and bombesin [Born) (95%). Blockade of the autonomic nervous system with chlorisondamine abolished the gastric inhibitory action induced by CRF, @End, CT, and NT, but not by CGRP and Born (1 nmollkg each). Corticotropin-releasing factor, pEnd, CT, NT, CGRP, and Born significantly inhibited gastric acid secretion stimulated by an intragastric 8% peptone meal for 2 h. None of these six peptides significantly altered plasma gastrin concentrations in response to the peptone meal as compared with
Carbocationic Polymerization in the Presence of Sterically Hindered Bases. IV. The Polymerization of Isobutylene by the “H2O”/AICI3Initiating System (1982)

Abstract The effect of 2,6-di-tert-butyl-pyridine (DtBP) on isobutylene polymerization induced by AlCl3 in n-hexane, CH2Cl2, and n-hexane/CH2Cl2 mixtures has been investigated. Polymerization carried out in the presence of DtBP invariably yielded much reduced yields, much elevated molecular weights, and noticeably narrower molecular weight dispersities than those carried out under identical conditions except in the absence of this hindered pyridine. As expected, conversions increase while [Mbar]n's decrease and [Mbar]w/[Mbar]n's broaden with increasing [AlCl3] in the absence of DtBP; however, in the presence of DtBP, increasing [AlCl3]'s lead to increased conversions, increasing [Mbar]n's, and narrowing [Mbar]w/[Mbar]n's. At constant [AlCl3], increasing [DtBP] tends to decrease yields but at the same time increases [Mbar]n and narrow [Mbar]w/[Mbar]n. Directionally these effects remain similar by changing the polarity of the medium. The proposition of proton scavenging during chain transfer to monomer by the hindered pyridine helps to explain these observations.
Stanovení mimodřeňové leukemické infiltrace u dětské akutnílymfoblastické leukemie a jeho klinické využití. Přehlednýčlánek a vlastní výsledky (2012)

Minimalni rezidualni nemoc (MRN) se stala důležitým
stratifikacnim kriteriem u modernich protokolů pro lecbu akutni
lymfoblasticke leukemie (ALL) děti i dospělých. Větsina
výsledků se týka kostni dřeně, studie zkoumajici MRN mimo
kostni dřeň jsou poměrně vzacne. Podle dosavadnich praci MRN v
periferni krvi u dětske ALL velmi dobře koreluje s MRN v kostni
dřeni v připadě T-ALL, u B-prekurzorove ALL je korelace horsi a
ve větsině připadů je zde MRN vice než o jeden řad nižsi než v
kostni dřeni. Přesto maji hladiny MRN v periferni krvi
prokazatelný prognostický význam v průběhu inicialni lecby
dětske ALL, jak jsme prokazali pro den 15 na protokolu ALL
IC-BFM 2002. Zatim neexistuje dostatek informaci o přinosu
vysetřovani mozkomisniho moku pomoci PCR a průtokove cytometrie
u pacientů při inicialni diagnoze ALL. Zda se, že průtokova
cytometrie zachyti podstatně vice pozitivnich výsledků než
klasicka mikroskopie. PCR i průtokova cytometrie jsou vhodne
pro vysetřeni leukemickeho postiženi v okamžiku relapsu v CNS,
v průběhu lecby relapsu je výpovědni hodnota opět sporna kvůli
nedostatecne kvalitě izolovane DNA v připadě PCR a kvůli rychle
degradaci vzorku při transportu v připadě průtokove cytometrie.
Jednoznacný přinos PCR je ve stanoveni soucasneho postiženi
kostni dřeně v okamžiku izolovaneho extramedularniho relapsu,
ktere zhorsuje prognozu pacienta.
ChemInform Abstract: Pyrinodemins B—D, Potent Cytotoxic Bis‐pyridine Alkaloids from Marine Sponge Amphimedon sp. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Advanced photonics for wired and wireless seamless networks (2015)

Wired and wireless seamless networks comprised of optical-fiber and radio-wave links can provide high-speed, resilient, and flexible broadband services, one of the important requirements for which is the precise and high-speed control of light waves based on advanced photonic technologies such as digital coherent detection, high-speed electro-optic conversion, and radio-over-fiber. In this paper, we focus on advanced photonic devices for optical and radio-wave links and on the expected performance and function of seamless networks.