gebhart/patrepeval huggingface dataset:
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms (2007)

These data demonstrate the inhibition of murine CIA by PD184352, support the hypothesis that antiinflammatory activity contributes to the mechanism of action of the inhibitor, and suggest that a selective inhibitor may effectively treat RA and other inflammatory disorders.
New Method Based on Direct Analysis in Real-Time Coupled with Time-of-Flight Mass Spectrometry (DART-ToF-MS) for Investigation of the Miscibility of Polymer Blends (2022)

The miscibility of a series of binary blends such as polystyrene/poly(methyl methacrylate) (PS/PMMA), polystyrene/poly(vinyl chloride)(PS/PVC), poly(vinyl chloride)/poly(polymethyl methacrylate)(PVC/PMMA) and poly(ethylene-co-vinyl alcohol)/poly(lactide-co-glycolide acid) PEVAL/PLGA with equal ratios and poly(ethylene oxide)/poly(hydroxyl propyl methyl cellulose) (PEO/PHPMC) containing 30 and 70 wt% PEO, which were randomly chosen among the widely systems reported in the literature, was investigated by a new method based on a direct analysis in real-time coupled with time-of-flight mass spectrometry (DART-ToF-MS). To reach this goal these pairs of polymers and copolymers were prepared by solvent casting method. As a first step, the DSC technique was undertaken in this work to highlight the published results on the miscibility of these binary systems. The thermogravimetry analysis (TGA) was used to define the optimum decomposition temperature of these blends programmed for the study of miscibility using the DART-ToF-MS technique. The results obtained by this method based on the comparison of the nature of the fragments resulting from the isothermal decomposition of the blend with those of their pure components have been very effective in demonstrating the character of miscibility of these systems. Indeed, it was found that the PS/PMMA-50 and PS/PVC-50 blends were immiscible, PVC/PMMA-50 and PEVAL/PLGA-50 miscible, and the PEO/PHMC partially miscible. This method, which is rapid and uses a very small amount of sample (1-2 mg) can be extended in its application to other blends whose other methods used have shown their limits due to the intrinsic properties of the polymers involved.
Development and properties of polycaprolactone/hydroxyapatite composite biomaterials (2003)

Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by two different procedures. The first one consists of a conventional blending of the polymer and the reinforcement material in an extruder. The second method consists of grafting of PCL on the surface of HA particles. This was achieved by a ring opening polymerization of caprolactone in the presence of HA, where its OH groups act as initiators. By this method, it was possible to obtain, in one step, a composite of PCL and surface modified HA. In both methods different percentages of filler were used to obtain several composites. These composites were characterized with respect to their mechanical properties, in the dry and wet state, by means of tensile tests on compression molded samples. The polymer/filler interface was analyzed by scanning electron microscopy. Water uptake and weight loss degradation experiments were also performed. An increase in the modulus for higher amounts of filler was, as expected, observed in the composites obtained by both processes. Furthermore, the mechanical properties of the materials in the wet state are considerably lower than those in the dry state. However, this difference is more significant for the composites obtained by conventional blending than for composites obtained by the grafting procedure, indicating that the later procedure can be an adequate route to reduce water susceptibility of PCL/HA composites.
A Practical Synthesis of Difunctional Organosilane Reagents and Their Application to the Diels−Alder Reaction (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Practical Synthesis of Difunctional Organosilane Reagents and Their Application to the Diels−Alder ReactionScott McN. Sieburth and Jerome LangView Author Information Department of Chemistry, State University of New York, Stony Brook, New York 11794-3400 Cite this: J. Org. Chem. 1999, 64, 6, 1780–1781Publication Date (Web):February 25, 1999Publication History Received15 January 1999Published online25 February 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/jo990082dhttps://doi.org/10.1021/jo990082drapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views2159Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Ethers,Group 14 compounds,Inorganic compounds,Organic compounds,Reaction mechanisms Get e-Alerts
Adaptive and active materials: Selected papers from the ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 09) (Oxnard, CA, USA, 21–23 September 2009) (2010)

The second annual meeting of the AMSE/AIAA Smart Materials, Adaptive Structures, and Intelligent Systems Conference (SMASIS) took place at the beautiful Mandalay Bay resort on the coast of southern California with a focus on the theme of 'Future horizons for multifunctional materials and systems'. This was reflected in keynote talks by Professor James Hubbard of UMD, 'The future of aerospace'; Professor Gregory Carman of UCLA, 'The future of active materials in medical devices'; and Dr Michael Tryson of Danfoss PolyPower A/S, 'Dielectric ElectroActive Polymers (DEAP)—viable members of the smart material family'. The SMASIS conference was divided into six symposia each of which include basic research, applied technological design and development, and industrial and governmental integrated system and application demonstrations. The six symposia were: SYMP 1 Multifunctional Materials SYMP 2 Active Materials, Mechanics and Behavior SYMP 3 Enabling Technologies and Integrated System Design SYMP 4 Structural Health Monitoring/NDE SYMP 5 Nonlinear Dynamics and Passive/Adaptive Controls SYMP 6 Bio-inspired Smart Materials and Structures Authors of papers in the materials areas (symposia 1, 2, and 6) were invited to write a full journal article on their presentation topic for publication in this special issue of Smart Materials and Structures. This set of papers demonstrates the exceptional quality and originality of the conference presentations. We are appreciative of their efforts to produce this collection of highly relevant articles on smart materials.
Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors (2015)

Astrocytes play a critical role during the development and the maintenance of the CNS in health and disease. Yet, their lack of accessibility from fetuses and from the brain of diseased patients has hindered our understanding of their full implication in developmental and pathogenic processes. Human pluripotent stem cells (PSCs) are an alternative source to obtain large quantities of astrocytes in vitro, for mechanistic studies of development and disease. However, these studies often require highly pure populations of astrocytes, which are not always achieved, depending on the PSC lines and protocols used. Here, we describe the generation and characterization of human PSC reporter lines expressing TagRFP driven by the ABC1D region of the human GFAP promoter, as new cellular model for generating homogenous population of astrocytes generated from CNS regionally defined PSC-derived neural progenitors. GFA(ABC1D)::TagRFP-expressing astrocytes can be purified by fluorescent-activated cell sorting and maintain a bright expression for several additional weeks. These express canonical astrocyte markers NF1A, S100β, CX43, GLAST, GS and CD44. These new cellular models, from which highly pure populations of fluorescence-expressing astrocytes can be obtained, provide a new platform for studies where pure or fluorescently labeled astrocyte populations are necessary, for example to assess pro-inflammatory cytokine and chemokine release in response to specific treatment, and uptake and degradation of fluorescently labeled pathogenic proteins, as reported in this study.
The Influence of Small Machining Errors on the Primary Current Distribution at a Recessed Electrode (1988)

The influence of small machining errors on the primary current distribution and resistance for a recessed electrode is explored through the use of conformal mapping coupled with numerical integration of the resulting integral equations. The influence of the depth to which the electrode is recessed and the angle between the electrode and the insulating wall is calculated for the current distribution on the electrode, the average current density that would be measured in an experimental cell, and the correction that would be made to compensate for cell resistance. The results show that the accuracy attainable in a modern machine shop is sufficient to justify neglecting the nonuniformity due to machining errors.
Cross-layer failure restoration techniques for a robust IPTV service (2008)

Broadcast TV distribution over an IP network requires stringent QoS constraints, such as low latency and loss. The main challenge to achieving these QoS objectives is how to design the network to respond to network failures. Streaming content in IPTV is typically delivered to the distribution points on the IP backbone using IP multicast, and in the case being considered, with protocol independent multicast source specific mode (PIM-SSM). A proven failure restoration technique at the IP layer is link-restoration using MPLS or layer-2 fast reroute (FRR). Link-based FRR creates a pseudo-wire or tunnel in parallel to the IP adjacencies (links) along the forwarding path used by the PIM tree. For each such tunnel both a primary and backup path are defined. The backup path is Layer-1-disjoint from the physical link and when the link fails, the pseudo-wire can be rapidly restored. Thus, single link failures are transparent to the interior gateway protocol (IGP). Although one may choose the back-up pathpsilas IGP link weights to avoid traffic overlap during any single link failure, multiple failures may still cause traffic overlap with FRR. We present a cross-layer restoration approach that combines both FRR-based restoration for single link failure and ldquohitlessrdquo (i.e., without loss) PIM tree reconfiguration algorithms to prevent traffic overlap when multiple failures occur.
Where Does Security Stand? New Vulnerabilities vs. Trusted Computing (2007)

How can we ensure that platform hardware, firmware, and software work in concert to withstand rapidly evolving security threats? Architectural innovations bring performance gains but can also create new security vulnerabilities. In this panel discussion, from the 2007 workshop on Computer Architecture Research directions, we assess the current state of security and discuss possible routes toward trusted computing.
Hydrogenation of acetylene into ethane–ethene mixtures over modified Pd–alumina catalysts (2020)

The diffuse-reflectance IR spectroscopic data using acetylene as a probe molecule showed the strengthening of basic properties of γ-Al2O3 modified with alkali metals in the sequence Al2O3 < Na/Al2O3 < K/Al2O3 < Rb/Al2O3 < Cs/Al2O3. The increase in the basicity of the support of Pd–alumina catalysts had a positive effect on the ethene selectivity in hydrogenation of acetylene in an ethane–ethene mixture.
Improvement of Annealing Properties of SiC/Si Structure (2000)

Properties of the SiC film/Si substrate structure annealed in a hydrogen atmosphere are investigated by scanning electron microscopy observation, X-ray diffraction measurement and Auger electron spectroscopy analysis. Two types of defects, the line and point defects which are formed in vacuum annealing, are also observed in the SiC/Si structure annealed in hydrogen-atmosphere, but the density of the point defects is little. The hydrogen atmosphere annealing results in high crystallinity of the SiC film, and low compositional change at the surface of the SiC film.
Fabrication of CuAl<sub>2</sub> <i>in-situ</i> Formation and Dispersed Porous Aluminum Core Filled in Hollow Pipe Composite Materials (2013)

Porous Al is superior in lightweight, high sound insulation and high energy absorption. In this study, copper powder dispersed porous Al core filled in hollow pipe composite materials was fabricated by friction welding and in-situ formation of CuAl2 was attempted for the reinforcement of porous Al. Al hollow disc filled with blowing agent, stabilization agent and Cu powder was put into hollow pipe and the rotating tool was pressed into Al hollow disc. Frictional heat softened Al hollow disc and precursor of porous Al was fabricated because the rotating tool dispersed the powder into Al by means of plastic flow of Al. It was shown that porous Al core filled in hollow pipe composite materials with porosity of approximately 60% and in-situ formation of CuAl2 was successfully fabricated at a holding temperature of 1003 K and at a holding time of 6 min 30 sec.
Adaptive optics optical coherence tomography (AO-OCT) (2017)

This chapter describes the developments in combining the high axial resolution afforded by optical coherence tomography (OCT) with the benefits of improved lateral resolution provided by adaptive optics (AO) for imaging of the living retina. OCT and AO developed along separate paths and it is only relatively that retinal imaging systems combining both technologies have been developed. The concept of AO was proposed in 1953 to address atmospheric turbulence. The chapter explores how AO is combined with OCT, its intrinsic advantages and also describes the status of the field. Combining AO with OCT provides three distinct advantages: increased lateral resolution, smaller speckle size, and increased sensitivity due to the ability to collect light over a larger pupil diameter. Almost all AO-OCT systems employ Shack–Hartmann the wavefront sensor to measure the ocular aberration. Wavefront sensorless AO systems have been demonstrated for imaging human retinas and mouse.
LiNbO 3 high-speed optical FSK modulator (2004)

An optical frequency-shift-keying (FSK) modulator with a pair of Mach-Zehnder structures that can switch optical frequency is developed. The operation is demonstrated at a 10 Gbit/s FSK transmission conducted on a standard singlemode fibre of 60 km, where the FSK signal is demodulated by a fibre Bragg grating.
Abstract C128: Small-molecule antagonists of MDM2 and MDMX. (2011)

Abstract The p53 tumor suppressor is controlled by MDM2 and MDMX that negatively modulate its activity. Both proteins possess p53-binding sites within their N-terminal domains and can inhibit the transcriptional activity of p53. However, only MDM2 can serve as E3 ubiquitin ligase for p53 and is thus responsible for its stability. MDMX does not have intrinsic ligase activity but can modulate the ligase activity of MDM2. Many human tumors overproduce MDM2 or MDMX to impair p53 function. Small-molecule MDM2 antagonists, the nutlins, interact specifically with the p53-binding pocket of MDM2 and can release p53 from negative control. Treatment of cancer cells expressing wild-type p53 with nutlins stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest and apoptosis in vitro and in vivo. However, nutlins and other published MDM2 antagonists do not inhibit the p53-MDMX interaction and their effectiveness can be compromised in tumors overexpressing MDMX. We identify the first small molecules that potently block p53 interaction with both MDM2 and MDMX (in vitro IC50 of 17 nM and 24 nM, respectively) by inhibitor-driven homo- and/or hetero-dimerization of MDM2 and MDMX proteins. Structural studies revealed that these idole-hydantoin compounds bind into and occlude p53 pockets of MDM2 and/or MDMX by inducing the formation of dimeric protein complexes kept together by a dimeric small-molecule core. This novel mode of inhibiting protein-protein interactions effectively stabilized p53 and activated p53 signaling in cancer cells, leading to cell cycle arrest and apoptosis. MDM2/MDMX antagonist, RO-5963, restored p53 apoptotic activity in cultured osteosarcoma cells in the presence of high levels of MDMX. RO-5963 showed a significantly better apoptotic activity against MCF7 and other solid tumor cell lines with higher MDMX levels than the MDM2-specific inhibitor, nutlin-3a, suggesting that dual antagonists may offer a more effective therapeutic modality for MDMX-overexpressing cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr C128.
Is there a direct link between an employee’s motivationand their employers Corporate Social Responsibility (CSR)policies and practices? (2019)

This research study was carried out to establish if there is a link between an employee’s motivation and their employer’s policies and practices. Extensive research has been conducted on employee commitment, organisational identification and leadership in relation to Corporate Social Responsibility. It has been widely accepted that one of the biggest if not the biggest asset of any organisation is their employees. This study aims to research what organisations are doing and what is deemed best practice to get and keep employees motivated as well as what part if any, Corporate Social Responsibility plays in the retention and motivation of their employees. As quoted by Richard Branson “learn to look after your staff first and the rest will follow” (Overall Motivation, 2019)
Creating a nano-sized light source by electrostatic trapping of nanoparticles in a nanogap (2006)

A MEMS-compatible, simple fabrication technique for a nano-sized light source was developed, and its characteristics were investigated. This technique is a combination of top-down electrode fabrication and bottom-up nanoparticle trapping. As regards this technique, nanoparticles (CdSe/ZnS core-shell nanoparticles) in a solvent were electrostatically trapped in a nanometer-sized gap between two electrodes formed on a p-type silicon on an insulator (SOI) wafer. The width of the nanogap, which was created by electron-beam lithography, was 200 nm. The trapped nanoparticles maintained a bridged form between the electrodes even after the solvent evaporated. Electroluminescence from the nanoparticles in the gap was observed when a voltage was applied to the electrodes. We measured an optical spectrum of the emission to find a peak which corresponds to the bandgap of the nanoparticles. A micro-photoluminescence measurement using a 405 nm laser suggested that the rest of the electrically induced emission was the black body emission of the locally heated nanoparticles. SEM observation showed that the emission area was small, i.e., 60 000 nm2. The nano light source fabricated by our new method is useful for integration with other devices owing to the simplicity of the fabrication method.
A High-Spin and Durable Polyradical:  Poly(4-diphenylaminium-1,2-phenylenevinylene) (2004)

A purely organic, high-spin, and durable polyradical molecule was synthesized: It is based on the non-Kekulé- and non-disjoint design of a pi-conjugated poly(1,2-phenylenevinylene) backbone pendantly 4-substituted with multiple robust arylaminium radicals. 4-N,N-Bis(4-methoxy- and -tert-butylphenyl)amino-2-bromostyrene 5 were synthesized and polymerized with a palladium-phosphine catalyst to afford the head-to-tail-linked polyradical precursors (1). Oxidation of 1 with the nitrosonium ion solubilized with a crown ether gave the aminium polyradicals (1(+)()) which were durable (half-life > 1 month) at room temperature in air. A high-spin ground state with an average S = (4.5)/2 for 1a(+) was proved even at room temperature by magnetic susceptibility, magnetization, ESR, and NMR measurements.
Imaging D2-Dopamine Receptor Concentration In Non-Human Primate Brain Using 18F-Fallypride (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
A Novel CoWP Cap Integration for Porous Low-WCu Interconnects With NH3 Plasma Treatment and Low-k Top (LKT) Dielectric Structure (2006)

A novel CoWP cap integration technology for lower leakage current and improved dielectric reliability is proposed for porous low-k/Cu interconnects, NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plasma treatment before SiCN deposition reduces leakage current and improves dielectric reliability such as time-dependent dielectric break-down (TDDB) of CoWP capped Cu interconnects. The TDDB lifetime much longer than 10 years is obtained. Moreover, the leakage current less than IE-14A/mm is obtained by low-k top (LKT) dielectric structure combined with the NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plasma treatment. In addition, 10% lower RC product is obtained by the LKT structure with CoWP cap
Recent trends in concentrated photovoltaics concentrators’ architecture (2014)

The field of concentrated photovoltaics (CPV) has met some remarkable advances in recent years. The continuous increase in conversion efficiency of multijunction solar cells and new advancements in optics have led to new demands and opportunities for optical design in CPV. This paper is a mini-review on current requirements for CPV optical design, and it presents some of the main trends in recent years on CPV systems architecture.