gebhart/patrepeval huggingface dataset:
Observation of the decay B s 0  → η c ϕ and evidence for B s 0  → η c π + π − (2017)

A study of B 0 s c and B 0 s c + -decays is performed using pp collision data corresponding to an integrated luminosity of 3.0 fb -1 , collected with the LHCb detector in Run 1 of the LHC. The observation of the decay B 0 s c is reported, where the c meson is reconstructed in the pp, K + K - + -, + - + -and K + K -K + K -decay modes and the (1020) in the K + K -decay mode. The decay B 0 s J/ is used as a normalisation channel. Evidence is also reported for the decay B 0 s c + -, where the c meson is reconstructed in the pp decay mode, using the decay B 0 s J/ + -as a normalisation channel. The measured branching fractions are
Leukotoxin (LtxA/Leukothera) induces ATP expulsion via pannexin-1 channels and subsequent cell death in malignant lymphocytes (2021)

Leukotoxin (LtxA) (Trade name, Leukothera) is a protein that is secreted from the oral bacterium Aggregatibacter actinomycetemcomitans, which targets and kills activated white blood cells (WBCs) by binding to lymphocyte function associated antigen-1 (LFA-1). Interaction between LtxA and Jurkat T-cells results in cell death and is characterized by increased intracellular Ca<sup>2+</sup>, activation of caspases, clustering of LtxA and LFA-1 within lipid rafts, and involvement of the Fas death receptor. Here, we show that LtxA can kill malignant lymphocytes via apoptotic and necrotic forms of cell death. We show that LtxA causes activation of caspases and PARP, cleavage of pannexin-1 (Panx1) channels, and expulsion of ATP, ultimately leading to cell death via apoptosis and necrosis. CRISPR-Cas9 mediated knockout (K/O) of Panx1 in Jurkat cells prevented ATP expulsion and resulted in resistance to LtxA for both apoptotic and necrotic forms of death. Resistance to necrosis could only be overcome when supplementing LtxA with endogenous ATP (bzATP). The combination of LtxA and bzATP promoted only necrosis, as no Panx1 K/O cells stained positive for phosphatidylserine (PS) exposure following the combined treatment. Inhibition of LtxA/bzATP-induced necrosis was possible when pretreating Jurkat cells with oATP, a P2X<sub>7</sub>R antagonist. Similarly, blockage of P2X<sub>7</sub>Rs with oATP prevented the intracellular mobilization of Ca<sup>2+</sup>, an important early step in LtxA induced cell death. We show that LtxA is able to kill malignant lymphocytes through an apoptotic death pathway which is potentially linked to a Panx1/P2X<sub>7</sub>R mediated necrotic form of death. Thus, inhibition of ATP release appears to significantly delay the onset of LtxA induced apoptosis while completely disabling the necrotic death pathway in T-lymphocytes, demonstrating the crucial role of ATP release in LtxA-mediated cell death.
The pili of Aeromonas hydrophila: identification of an environmentally regulated "mini pilin". (1990)

Ultrastructural studies of Aeromonas hydrophila strain AH26 revealed two distinctive pilus types: "straight" pili appear as brittle, rod-like filaments, whereas "flexible" pili are supple and curvilinear. Straight pili are produced constitutively under all tested conditions of growth. In contrast, the expression of flexible pili is regulated by physical and chemical variables, being produced at 22 vs. 37 degrees C, in a liquid vs. a solid medium, and when the availability of free-iron is reduced by the presence of deferoxamine mesylate. Both pilus proteins were purified and biochemically and functionally characterized. The major repeating subunit of the straight pilus is a 17,000-mol wt polypeptide with amino acid sequence homology with Escherichia coli type 1 and Pap pili. The flexible pilus filament is a homopolymer composed of a novel 46 amino acid polypeptide. Resistance of the flexible pilus filament to disaggregation using various chemical treatments was demonstrated; its stability as a polymer and its apparent mechanical strength seem to be conferred by a 20 amino acid hydrophobic, COOH-terminal domain. Purified straight pili lack hemagglutinating function. In contrast, purified flexible pili cause the agglutinin of human, guinea pig, ovine, bovine, and avian erythrocytes, although this property could only be demonstrated in the presence of divalent cations and was most evident at 4 vs. 22 degrees C. Taken together, these results suggest that the pathogenic and ecological roles of the flexible pilus are related to this species' existence as a free-living organism in aquatic environments and its ability to cause infections, both in cold-blooded vertebrates and the human intestine.
PN-type quantum barrier for InGaN/GaN light emitting diodes (2013)

In this work, InGaN/GaN light-emitting diodes (LEDs) with PN-type quantum barriers are comparatively studied both theoretically and experimentally. A strong enhancement in the optical output power is obtained from the proposed device. The improved performance is attributed to the screening of the quantum confined Stark effect (QCSE) in the quantum wells and improved hole transport across the active region. In addition, the enhanced overall radiative recombination rates in the multiple quantum wells and increased effective energy barrier height in the conduction band has substantially suppressed the electron leakage from the active region. Furthermore, the electrical conductivity in the proposed devices is improved. The numerical and experimental results are in excellent agreement and indicate that the PN-type quantum barriers hold great promise for high-performance InGaN/GaN LEDs.
Dose-finding study of Leuplin depot for prevention of premature luteinizing hormone surge during controlled ovarian stimulation: a pilot study in intrauterine insemination treatment (2016)

The 1/4 dose of Leuplin depot is the minimal effective dose to prevent premature LH surge. Further trial is worthwhile to compare the reducing dose Leuplin depot and daily low-dose leuprolide in in vitro fertilization (IVF) programs.
A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis (2015)

β-Lactamases are bacterial enzymes that hydrolyze β-lactam antibiotics. TEM-1 is a prevalent plasmid-encoded β-lactamase in Gram-negative bacteria that efficiently catalyzes the hydrolysis of penicillins and early cephalosporins but not oxyimino-cephalosporins. A previous random mutagenesis study identified a W165Y/E166Y/P167G triple mutant that displays greatly altered substrate specificity with increased activity for the oxyimino-cephalosporin, ceftazidime, and decreased activity toward all other β-lactams tested. Surprisingly, this mutant lacks the conserved Glu-166 residue critical for enzyme function. Ceftazidime contains a large, bulky side chain that does not fit optimally in the wild-type TEM-1 active site. Therefore, it was hypothesized that the substitutions in the mutant expand the binding site in the enzyme. To investigate structural changes and address whether there is an enlargement in the active site, the crystal structure of the triple mutant was solved to 1.44 Å. The structure reveals a large conformational change of the active site Ω-loop structure to create additional space for the ceftazidime side chain. The position of the hydroxyl group of Tyr-166 and an observed shift in the pH profile of the triple mutant suggests that Tyr-166 participates in the hydrolytic mechanism of the enzyme. These findings indicate that the highly conserved Glu-166 residue can be substituted in the mechanism of serine β-lactamases. The results reveal that the robustness of the overall β-lactamase fold coupled with the plasticity of an active site loop facilitates the evolution of enzyme specificity and mechanism.
Feedback-based Topological Mechanical Metamaterials (2020)

We present a method to design autonomous active metamaterials that can create arbitrary physical interactions on a single, reprogrammable platform, including non-local, non-linear, time-dependent or non-Newtonian couplings. The underlying principle includes application of external forces to a regular mechanical lattice, and processing them in real-time through closed-loop controllers that are pre-programmed to create desired couplings between the metamaterial sites. As an example, we demonstrate that a lattice constrained to out-of-plane vibration can be programmed to exhibit an analogy either of the quantum spin Hall effect, or the quantum Hall effect, thereby enabling a versatile unconventional guiding of mechanical waves.
At-Wavelength Interferometry of High-NA Diffraction-Limited EUV Optics (2004)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kenneth A. Goldberg, Patrick Naulleau, Senajith Rekawa, Paul Denham, J. Alexander Liddle, Erik Anderson, Keith Jackson, Jeffrey Bokor, David Attwood; At‐Wavelength Interferometry of High‐NA Diffraction‐Limited EUV Optics. AIP Conf. Proc. 12 May 2004; 705 (1): 855–860. https://doi.org/10.1063/1.1757930 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
EFFECTS OF MITRAL REGURGITATION ON THE REFLEX DIURESIS TO PULMONARY LYMPHATIC OBSTRUCTION IN RABBITS (2007)

Increasing the extravascular fluid of the airways acutely by obstructing pulmonary lymph drainage causes a reflex diuresis mediated by neuronal nitric oxide synthase in the renal medulla. The authors examined this reflex in rabbits with a chronic increase in extravascular fluid of the airways resulting from surgically induced mitral regurgitation. Intact rabbits served as controls. Renal neuronal (nNOS) and endothelial (eNOS) nitric oxide synthase expressions were also examined. The reflex was absent in rabbits with mitral regurgitation. There were significant increases in medullary and cortical nNOS mRNA compared to controls. The observed changes in mRNA levels correlated with nNOS protein levels. eNOS mRNA was unaffected.
A heuristic sensor fusion method for assembly error detection (1993)

info:eu-repo/semantics/published
SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila (2010)

DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have uncovered revealed that DNA methylation patterns are dynamic rather than static and change in a gene-specific fashion during development and in diseased cells. However, the factors and mechanisms involved in dynamic, postembryonic DNA methylation remain unclear. Methylation of lysine 9 in histone H3 (H3-K9) by members of the Su(var)3-9 family of histone methyltransferases (HMTs) triggers embryonic DNA methylation in Arthropods and Chordates. Here, we demonstrate that Drosophila SETDB1 (dSETDB1) can mediate DNA methylation and silencing of genes and retrotransposons. We found that dSETDB1 tri-methylates H3-K9 and binds methylated CpA motifs. Tri-methylation of H3-K9 by dSETDB1 mediates recruitment of DNA methyltransferase 2 (Dnmt2) and Su(var)205, the Drosophila ortholog of mammalian "Heterochromatin Protein 1", to target genes for dSETDB1. By enlisting Dnmt2 and Su(var)205, dSETDB1 triggers DNA methylation and silencing of genes and retrotransposons in Drosophila cells. DSETDB1 is involved in postembryonic DNA methylation and silencing of Rt1b{} retrotransposons and the tumor suppressor gene retinoblastoma family protein 1 (Rb) in imaginal discs. Collectively, our findings implicate dSETDB1 in postembryonic DNA methylation, provide a model for silencing of the tumor suppressor Rb, and uncover a role for cell type-specific DNA methylation in Drosophila development.
A closed loop controlled bidirectional contactless grid interface with a soft DC-link (2015)

Bidirectional contactless grid interfaces are gaining popularity as an alternative to conventional hardwired interfaces in vehicle-to-grid (V2G) and grid-to-vehicle (G2V) applications. However, such systems typically employ a large input inductor as well as a large and expensive electrolytic DC-link capacitor, which compromises the reliability of the entire system. Although, back-to-back converter (BTBC) based bidirectional contactless grid interfaces with a variable or soft DC-link have been recently proposed as an alternative, the total harmonic distortion (THD) associated with grid currents of the BTBC based system exceeds the acceptable limits set by standards. As a solution, this paper proposes a closed loop controlled bidirectional contactless interface that employs a small input inductor, a small DC-link capacitor, and a grid converter operated at low frequency, for grid integration. The feasibility of the proposed system is validated through simulations of a 1 kW simulation model.
Propylene/Nitrogen Separation in a By-Stream of the Polypropylene Production: From Pilot Test and Model Validation to Industrial Scale Process Design and Optimization (2013)

Two industrial-scale pressure swing adsorption (PSA) processes were designed and optimized by simulations: recovery of only nitrogen and recovery of both nitrogen and propylene from a polypropylene manufacture purge gas stream. MIL-100(Fe) granulates were used as adsorbent. The mathematical model employed in the simulations was verified by a PSA experiment. The effect of several operating parameters on the performance of the proposed PSA processes was investigated. For the nitrogen recovery, a 5-step 2-column PSA process produced a nitrogen stream of 95.4% purity with recovery of 85.2%, productivity of 6.0 mol N2/kg adsorbent/h, and power consumption of 156 Wh/kgN2. Nitrogen and propylene with 96.2% and 97.6% purity, respectively, were obtained from the 6-step 3-column nitrogen and propylene recovery PSA process. The nitrogen and propylene recoveries obtained are 98.4% and 91.0%, respectively. The nitrogen and propylene productivities were estimated as 4.61 and 1.83 mol product/kg adsorbent/h and the power consumption as 383 Wh/kgN2.
A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome (2015)

The study developed a prognostic signature score with a propensity to detect non-EMT features, including epithelial cancer stem cell-related properties, thereby improving its potential to predict metastasis and poorer outcome in stage I-III patients.
Scan test data volume reduction in multi-clocked designs with safe capture technique (2003)

As a result of increasing design size and complexity, the multiple clock domain design style has become a new trend in the industry. Several techniques to test circuits with multiple clocks are known; however, they often result in increased test time and tester memory for large and complex circuits. This paper presents a strategy to reduce the test pattern count during ATPG by forcing a safe capture behavior when multiple clocks are applied during capture. The usage of multiple clocks allows additional observability, which can significantly reduce the pattern count for circuits with many clocks. Experimental results indicate that proposed strategy results in larger and moreover, more consistent reduction in test sizes.
Nocturnal Enuresis Is Associated with Attention Deficit Hyperactivity Disorder and Conduct Problems (2013)

Enuresis is significantly associated with ADHD and CD, so these conditions must be assessed together during the evaluation of children with enuresis.
ABTRAG UND TRAGWERKSERNEUERUNGEN BEI PILZBRUECKEN DER BRENNER AUTOBAHN UNTER VERKEHR (1996)

Der Erhaltungszustand der Pilzbruecken der Brenner Autobahn erforderte den Ersatz der Ueberbauten, der ohne Verkehrsunterbrechung durchzufuehren war. Erschwerend kam hinzu, dass bei den sogenannten Vollpilzen beide Richtungsfahrbahnen auf einem gemeinsamen Tragwerk aufruhen. Das Ausfuehrungsprojekt sieht an die verbleibenden Hohlstuetzen angespannte Querhaeupter vor, auf die neue, durchlaufende Balkentragwerke aufgelegt werden. Durch den abschnittsweisen Rueckbau des Pilzquerschnittes und anschliessenden Aufbau des neuen Tragwerks konnte der Forderung nach Aufrechterhaltung des Verkehrs entsprochen werden. Im vorliegenden Bericht wird ueber das Entwurfskonzept, die Herstellung der Querjoche und den Rueckbau der Pilzbruecken berichtet. (A*)
Engineering Musculoskeletal Grafts for Multi-Tissue Unit Repair: Lessons From Developmental Biology and Wound Healing (2021)

In the musculoskeletal system, bone, tendon, and skeletal muscle integrate and act coordinately as a single multi-tissue unit to facilitate body movement. The development, integration, and maturation of these essential components and their response to injury are vital for conferring efficient locomotion. The highly integrated nature of these components is evident under disease conditions, where rotator cuff tears at the bone-tendon interface have been reported to be associated with distal pathological alterations such as skeletal muscle degeneration and bone loss. To successfully treat musculoskeletal injuries and diseases, it is important to gain deep understanding of the development, integration and maturation of these musculoskeletal tissues along with their interfaces as well as the impact of inflammation on musculoskeletal healing and graft integration. This review highlights the current knowledge of developmental biology and wound healing in the bone-tendon-muscle multi-tissue unit and perspectives of what can be learnt from these biological and pathological processes within the context of musculoskeletal tissue engineering and regenerative medicine. Integrating these knowledge and perspectives can serve as guiding principles to inform the development and engineering of musculoskeletal grafts and other tissue engineering strategies to address challenging musculoskeletal injuries and diseases.
Discovery of the RSV Inhibitor TMC353121 (2011)

This chapter contains sections titled: Introduction Discovery Synthesis Mechanism of Action Efficacy in Animal Species Conclusions References
Optimization of Correlated Source Coding for Event-Based Monitoring in Sensor Networks (2009)

Motivated by the paradigm of event-based monitoring, which can potentially alleviate the inherent bandwidth and energy constraints associated with wireless sensor networks, we consider the problem of joint coding of correlated sources under a cost criterion that is appropriately conditioned on event occurrences. The underlying premise is that individual sensors only have access to partial information and, in general, cannot reliably detect events. Hence, sensors optimally compress and transmit the data to a fusion center, so as to minimize the expected distortion in segments containing events. In this work, we derive and demonstrate the approach in the setting of entropy constrained distributed vector quantizer design,using a modified distortion criterion that appropriately accounts for the joint statistics of the events and the observation data. Simulation results show significant gains over conventional design as well as existing heuristic based methods, and provide experimental evidence to support the promise of our approach.
Pharmacokinetics of 111In-labeled OC-125 antibody in cancer patients compared with the 19-9 antibody. (1987)

We recently reported on the pharmacokinetics in 14 cancer patients of the 19-9 antibody radiolabeled with 111In. We have now repeated this investigation in 18 cancer patients using the OC-125 antibody, in part to compare the in vivo behavior of two murine monoclonal antibodies of the same subclass administered as the F(ab')2 fragments, by the same route and at the same dose. As in the earlier investigation, 1 mg of fragments was infused i.v., and organ quantitation was obtained for up to 72 h along with frequent blood and urine samples for chromatographic evaluation. Analysis of urine showed that activity clearance by this route amounted to 0.29%/h and consisted of labeled DTPA only in early samples and metabolic products thereafter. Analysis of serum samples often showed the presence of a high-molecular-weight species appearing within 24 h. This species is probably due to antibody binding to circulating antigen, although the percentage of circulating activity present as this species did not correlate well with circulating antigen levels. As before, organ accumulation was greatest in the liver, although levels were significantly reduced (12% compared to 20% of administered dose at 24 h, P less than 0.01). Plasma clearance was also significantly different: whereas the label in the case of the OC-125 antibody showed one-compartment clearance kinetics and remained in the plasma compartment, in the 19-9 case the label diffused to a second, unidentified compartment.
Toward Rational Composite Electrodes for Improved Li Batteries (2007)

1 Results Although electrodes for lithium batteries are generally prepared with standard formulations and routine processing conditions,more and more studies report relationships between processing conditions,composite electrode morphology and electrochemical performance.In our previous work,we obtained a 50% increase of the cycling capacity of Li1.1V3O8 based electrodes after using a PEO binder which had been pre-plasticized by the solvent (ethylene carbonate (EC) + propylene carbonate (PC)) of the liq...
Modeling the Turkish Straits System With a Multi-Scale Model (2010)

Two narrow, shallow straits, i.e. the Dardanelles and the Bosphorus, form a physical connection between the Marmara Sea and its adjacent water bodies, the Aegean Sea to the southwest and the Black Sea to the northeast. This collection of seas and straits is known as the Turkish Strait System (TSS). Saline, dense water from the Aegean flows in a deep, lower layer through the Marmara Sea to the Black Sea while fresher and lighter Black Sea water flows in a surface layer to the Aegean Sea. Flow within the TSS is often interpreted in terms of classic two-layer estuarine flow. Though the TSS dynamics are the result of interconnections between the straits and the ocean basins, earlier modeling efforts have focused dynamical studies on individual straits or seas. Often the geometric complexity, the broad range of spatial scales present, and the computational resources required to represent such disparity have prevented a study of the entire TSS as a whole.
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide GnRH Antagonist Elagolix (2008)

ABSTRACT Context: Parenteral administration of peptide GnRH analogs is widely employed for treatment of endometriosis, fibroids and in assisted-reproductive therapy protocols. Elagolix is a novel, orally available nonpeptide GnRH antagonist. Objective: To evaluate the safety, pharmacokinetics and inhibitory effects on gonadotropins and estradiol of single dose and 7-day elagolix administration to healthy premenopausal women. Design: This was a first-in-human, double-blind, placebo-controlled, single- and multiple dose study with sequential dose-escalation. Participants: Fifty-five healthy, regularly cycling pre-menopausal women. Interventions: Subjects were administered a single oral dose of 25 to 400 mg or placebo. In a second arm of the study, subjects received placebo or 50, 100, or 200 mg q.d. or 100 mg b.i.d. for seven days. Treatment was initiated on Day 7 (±1) following onset of menses. Main Outcome Measures: Safety, tolerability, pharmacokinetics and serum LH, FSH and estradiol concentrations.