gebhart/patrepeval huggingface dataset:
Chirped return-to-zero formats for ultra long-haul fiber communications (2004)

The Chirped Return to Zero modulation format is now widely deployed in Tyco Telecommunication's undersea terminal equipment. This modulation format has allowed for an increase in capacity, system reach and performance of undersea telecommunications systems. Introduction - The Chirped Return to Zero modulation format (or CRZ) can provide a combination of increased capacity, system reach, and performance for long-haul undersea cable systems. The performance of a long-haul undersea cable system can be degraded by a combination of the transmission fiber's nonlinear index and chromatic dispersion. R&D efforts to understand these impairments have lead to many important transmission improvement techniques such as dispersion management, new transmission fibers, FEC, and modulation formats. In this paper we review the basics of the CRZ modulation format, add some historical perspective on this (and other) modulation formats, and then give simple time/frequency domain arguments for why the CRZ modulation format is useful. Historical Perspective - Today the subject of modulation formats is hot, but it is not new. Modulation formats have been debated over the entire history of optical fiber communications. Early optical fiber transmission demonstrations used the Non Return to Zero (NRZ) modulation format because it was easy to generate and detect (1). In the 1980's many fiber optic research organizations studied coherent optical communication techniques (including DPSK) to increase receiver sensitivity and increase receiver selectivity. (2) Work on coherent optical communications slowed down dramatically in the early 1990's with the demonstration of the Erbium-doped Fiber amplifier. Long EDFA-based systems started with the NRZ modulation format. Later, formats such as RZ and CRZ took hold for today's 10Gb/s systems. Recently, there has been a strong interest in the DPSK format because of the 3 dB receiver advantage (3), and in bandwidth reduced formats such as duobinary.
Real-time image distortion correction: Analysis and evaluation of FPGA-compatible algorithms (2016)

Image distortion correction is a critical preprocessing step for a variety of computer vision and image processing algorithms. Standard real-time software implementations are generally not suited for direct hardware porting, so appropriated versions need to be designed in order to obtain implementations deployable on FPGAs. In this paper, hardware-compatible techniques for image distortion correction are introduced and analyzed in details. The considered solutions are compared in terms of output quality by using a geometrical-error-based approach, with particular emphasis on robustness with respect to increasing lens distortion. The required amount of hardware resources is also estimated for each considered approach.
GaAs/AlGaAs/GaAs Heterojunction Photoconductor Array For Programmable Frequency Excision And Adaptive Filtering (1989)

The first demonstration of acousto-optical excision using a GaAs photodetector array is reported. A maximum isolation of 40 dB was obtained using a six element GaAs interdigitated finger heterojunction photoconductor array. The center frequency was 45 MHz, and the swept bandwidth was 3 MHz. The response of discrete GaAs heterojunction photoconductors was linear with bias voltage potentially making them useful for performing multiplication functions in optical analog filters. Concepts of using these photoconductors for optical adaptive filters are discussed.
N-terminal proteoforms may engage in different protein complexes (2023)

Alternative translation initiation and alternative splicing may give rise to N-terminal proteoforms, proteins that differ at their N-terminus compared with their canonical counterparts. Such proteoforms can have altered localizations, stabilities, and functions. Although proteoforms generated from splice variants can be engaged in different protein complexes, it remained to be studied to what extent this applies to N-terminal proteoforms. To address this, we mapped the interactomes of several pairs of N-terminal proteoforms and their canonical counterparts. First, we generated a catalogue of N-terminal proteoforms found in the HEK293T cellular cytosol from which 22 pairs were selected for interactome profiling. In addition, we provide evidence for the expression of several N-terminal proteoforms, identified in our catalogue, across different human tissues, as well as tissue-specific expression, highlighting their biological relevance. Protein-protein interaction profiling revealed that the overlap of the interactomes for both proteoforms is generally high, showing their functional relation. We also showed that N-terminal proteoforms can be engaged in new interactions and/or lose several interactions compared with their canonical counterparts, thus further expanding the functional diversity of proteomes.
Weighted Sum-Rate Maximization for MIMO Downlink Systems Powered by Renewables (2016)

Optimal resource management for smart grid powered multi-input multi-output (MIMO) systems is of great importance for future green wireless communications. A novel framework is put forth to account for the stochastic renewable energy sources (RES), dynamic energy prices, as well as random wireless channels. Based on practical models, the resource allocation task is formulated as an optimization problem that aims at maximizing the weighted sum-rate of the MIMO broadcast channels. A two-way transaction mechanism and storage units are introduced to accommodate the RES variability. In addition to system operating constraints, a budget threshold is imposed on the worst-case energy transaction cost due to the possibly adversarial nature. Capitalizing on the uplink-downlink duality and the Lagrangian relaxation-based subgradient method, an efficient algorithm is developed to obtain the optimal strategy. Generalizations to the setups of time-varying channels and ON-OFF transmissions are also discussed. Numerical results are provided to corroborate the merits of the novel approaches.
The Serum and Glucocorticoid-Inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1 (2002)

Mineralocorticoids stimulate Na(+) reabsorption and K(+) secretion in principal cells of connecting tubule and collecting duct. The involved ion channels are ENaC and ROMK1, respectively. In Xenopus oocytes, the serum and glucocorticoid-sensitive kinase SGK1 has been shown to increase ENaC activity by enhancing its abundance in the plasma membrane. With the same method, ROMK1 appeared to be insensitive to regulation by SGK1. On the other hand, ROMK1 has been shown to colocalize with NHERF2, a protein mediating targeting and trafficking of transport proteins into the cell membrane. The present study has been performed to test whether NHERF2 is required for regulation of ROMK1 by SGK1. Coexpression of neither NHERF2 nor SGK1 with ROMK1 increases ROMK1 activity. However, coexpression of NHERF2 and SGK1 together with ROMK1 markedly increases K(+) channel activity. The combined effect of SGK1 and NHERF2 does not significantly alter the I/V relation of the channel but increases the abundance of the channel in the membrane and decreases the decay of channel activity after inhibition of vesicle insertion with brefeldin. Coexpression of NHERF2 and SGK1 does not modify cytosolic pH but leads to a slight shift of pK(a) of ROMK1 to more acidic values. In conclusion, NHERF2 and SGK1 interact to enhance ROMK1 activity in large part by enhancing the abundance of channel protein within the cell membrane. This interaction allows the integration of genomic regulation and activation of SGK1 and NHERF2 in the control of ROMK1 activity and renal K(+) excretion.
Room-temperature magnetically modulated electroluminescence from hybrid organic/inorganic spintronics devices (2013)

We report a hybrid organic/inorganic magnetic-field controlled light-emitting diode (h-OLED), in which an inorganic magnetic tunnel junction (MTJ) with large room temperature magnetoresistance is coupled to an OLED having efficient electroluminescence. In operation, the large resistance mismatch between the MTJ and OLED components is suppressed due to the non-linear I-V characteristic of the OLED. This leads to ∼80% giant magneto-electroluminescence at room temperature with emission in the red, green, and blue spectral ranges.
ChemInform Abstract: Synthesis and Evaluation of CC‐1065 and Duocarmycin Analogues Incorporating the Iso‐CI and Iso‐CBI Alkylation Subunits: Impact of Relocation of the C‐4 Carbonyl. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines (2021)

Understanding the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants of concern and other sarbecoviruses is key for guiding vaccine development decisions and public health policies. We show that a clinical stage multivalent SARS-CoV-2 receptor-binding domain nanoparticle vaccine (SARS-CoV-2 RBD-NP) protects mice from SARS-CoV-2-induced disease after a single shot, indicating that the vaccine could allow dose-sparing. SARS-CoV-2 RBD-NP elicits high antibody titers in two non-human primate (NHP) models against multiple distinct RBD antigenic sites known to be recognized by neutralizing antibodies. We benchmarked NHP serum neutralizing activity elicited by RBD-NP against a lead prefusion-stabilized SARS-CoV-2 spike immunogen using a panel of single-residue spike mutants detected in clinical isolates as well as the B.1.1.7 and B.1.351 variants of concern. Polyclonal antibodies elicited by both vaccines are resilient to most RBD mutations tested, but the E484K substitution has similar negative consequences for neutralization, and exhibit modest but comparable neutralization breadth against distantly related sarbecoviruses. We demonstrate that mosaic and cocktail sarbecovirus RBD-NPs elicit broad sarbecovirus neutralizing activity, including against the SARS-CoV-2 B.1.351 variant, and protect mice against severe SARS-CoV challenge even in the absence of the SARS-CoV RBD in the vaccine. This study provides proof of principle that sarbecovirus RBD-NPs induce heterotypic protection and enables advancement of broadly protective sarbecovirus vaccines to the clinic.
Rôle de l’éthylène dans l'accumulation de capsidiol et la sensibilité à Phytophthora capsici chez le piment traité par un éliciteur (1985)

National audience
Effects of rapid thermal annealing on structure and luminescence of self-assembled InAs/GaAs quantum dots (1998)

Postgrowth rapid thermal annealing was used to modify the structural and optical properties of the self-assembled InAs quantum dots grown on GaAs substrates by molecular beam epitaxy. It is found that significant narrowing of the luminescence linewidth (from 78.9 to 20.5 meV) from the InAs dot layer occurs together with about 260 meV blueshift at annealing temperatures up to 850 °C. Observation of high-resolution transmission electron microscopy shows the existence of the dots under lower annealing temperatures but disappearance of the dots annealed at 850 °C. The excited-state-filling experiments for the samples show that the luminescence of the samples annealed at 850 °C exhibits quantum well-like behavior. Comparing with the reference quantum well, we demonstrate significant enhancement of the interdiffusion in the dot layer.
Parametric Macromodeling of Time Domain Responses (2008)

This paper shows that accurate parametric macromodels can be computed from transient port responses which are varied by one or more design variables. The poles of the parametric macromodel are guaranteed to be stable by construction, and passivity can be enforced as a post-processing step.
Cavitation Instabilities During the Development Testing of a Liquid Oxygen Pump (2016)

Inducers are critical to the minimization of the degradation of liquid oxygen pumps and the maximization of the thrust-to-weight ratio of liquid rocket engines, but create cavitation instabilities that have adverse effects on their reliabilities. To examine the cavitation instabilities that arose during the development testing of a liquid oxygen pump that uses water and liquid oxygen as its working media, accelerometers were employed instead of pressure transducers, which are complicated to install. The supersynchronous rotating cavitation and asymmetric cavitation of the pump were characterized by analyzing the signals from the accelerometers, and these results were found to be in good agreement with those of previous studies. Supersynchronous rotating cavitation was found to occur in the tests of both propellants, whereas asymmetric cavitation was found to be dominant in the liquid oxygen test.
Pump-seed synchronization measurements for high-power short-pulse pumped few-cycle OPCPA system (2010)

We present the development of an optically synchronized frontend of a high-power short-pulse pumped few-cycle OPCPA system and single shot pump-seed timing jitter measurements at the position of its first OPCPA stage.
Identification of a 6 gene molecular predictor of lapatinib related benefit: From breast cancer cell lines to a phase III trial (2008)

1043 Background: Identification of molecular predictors of response is an important aspect of efforts to individualize cancer treatment. Responses to lapatinib (L), an oral, dual inhibitor of HER2 and EGFR approved in combination with capecitabine for HER2+ metastatic breast cancer (MBC), were evaluated in a panel of BC cell lines. Computational approaches were then used to identify a 6-gene predictor of quantitative response to L. Methods: The clinical utility of the 6-gene predictor was tested retrospectively using a Panomics assay in tumor tissue samples from HER2-negative or HER2-untested MBC patients (pts) enrolled in a phase III trial of paclitaxel (P) or P+L. Panomics results were compared with HER2 fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) status and discordant cases were analyzed. Dichotomous response patterns of HER2+ pts and a computational model that predicts L sensitivity or resistance is described. Results: Tissue samples from 302 pts were tested using the branch capture Panomics assay, FISH and IHC. In the Panomics assay, pts with HER2 levels greater than 50% of GAPDH levels were considered HER2-positive. Pearson's correlation coefficient indicated a linear correlation of 0.75 (p<0.001) between FISH ratio and Panomics assay. Panomics and progression-free survival (PFS) data were available for 159 pts on L+P. Median PFS in panomics HER2+ group was 32.9 weeks vs. 22.4 weeks in the HER2-negative group. The 6-gene model was used to predict responders and non-responders to L in the HER2+ group. PFS comparison of 24 hypothesized sensitive tumors vs. 25 hypothesized resistant tumors treated with L+P indicated that the predictor developed in vitro has the potential to predict clinical response to L (HR=0.58, 95% CI=0.30, 1.11). FISH and Panomics assay discordance analysis is ongoing and will be reported. Validation of this approach will be evaluated in additional pt cohorts. Conclusions: This study establishes proof of principle strategies for identification of predictive markers, and can be further developed to guide their broad clinical introduction to appropriately target pts treated with L. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration GlaxoSmithKline GlaxoSmithKline, Roche GlaxoSmithKline Genentech, GlaxoSmithKline, Roche Genentech, GlaxoSmithKline
4D human body posture estimation based on a motion capture system and a multi-rigid link model (2012)

Human motion analysis in various fields such as neurophysiology, clinical medicine, and sports sciences utilizes a multi-rigid link model of a human body for considering kinetics by solving inverse dynamics of a motion, in which a motion capture system with reflective markers are often used to measure the motion, and then the obtained motion are mapped onto the multi-rigid link model. However, algorithms for such a mapping from spatio-temporal positions of the markers to the corresponding posture of the model are not always fully disclosed. Moreover, a common difficulty for such algorithms is an error caused by displacements of the markers attached on the body surface, referred to as the skin motion error. In this study, we developed a simple algorithm that maps positions of the markers to the corresponding posture of a rigid link model, and examined accuracy of the algorithm by evaluating quantitatively differences between the measured and the estimated posture. We also analyzed the skin motion error. It is shown that magnitude of the error was determined not only by the amplitude of the skin motion, but also by the direction of the marker displacement relative to the frame of reference attached to each segment of the body.
The alternative complement pathway regulates pathological angiogenesis in the retina (2014)

A defining feature in proliferative retinopathies is the formation of pathological neovessels. In these diseases, the balance between neovessel formation and regression determines blindness, making the modulation of neovessel growth highly desirable. The role of the immune system in these retinopathies is of increasing interest, but it is not completely understood. We investigated the role of the alternative complement pathway during the formation and resolution of aberrant neovascularization. We used alternative complement pathway-deficient (Fb(-/-)) mice and age- and strain-matched control mice to assess neovessel development and regression in an oxygen-induced retinopathy (OIR) mouse model. In the control mice, we found increased transcription of Fb after OIR treatment. In the Fb(-/-) mice, we prepared retinal flatmounts and identified an increased number of neovessels, peaking at postnatal day 17 (P17; P=0.001). Subjecting human umbilical vein endothelial cells (HUVECs) to low oxygen, mimicking a characteristic of neovessels, decreased the expression of the complement inhibitor Cd55. Finally, using laser capture microdissection (LCM) to isolate the neovessels after OIR, we found decreased expression of Cd55 (P=0.005). Together, our data implicate the alternative complement pathway in facilitating neovessel clearance by down-regulating the complement inhibitor Cd55 specifically on neovessels, allowing for their targeted removal while leaving the established vasculature intact.-Sweigard, J. H., Yanai, R., Gaissert, P., Saint-Geniez, M., Kataoka, K., Thanos, A., Stahl, G. L., Lambris, J. D., Connor, K. M. The alternative complement pathway regulates pathological angiogenesis in the retina.
Autoimmune Myocarditis Does Not Require B Cells for Antigen Presentation (1999)

Abstract T cells constitute the pathogenic effector cell population in autoimmune myocarditis in BALB/c mice. Using mice rendered deficient for B cells by a targeted disruption to the IgM transmembrane domain or by treatment with anti-IgM Ab from birth, we asked whether B cells are a critical APC in the induction of autoimmune myocarditis. B cell-deficient mice immunized with cardiac myosin develop myocarditis comparable in incidence and severity to that in wild-type mice, suggesting that autoreactive T cells that cause myocarditis in BALB/c mice are activated by macrophages or dendritic cells. Since it does not appear that presentation of cryptic epitopes is critical for the breakdown of self tolerance, potentially pathogenic T cells recognizing dominant myosin epitopes must have escaped tolerization. Either anatomic sequestration of cardiac myosin peptide-MHC complexes or subthreshold presentation of cardiac myosin peptides by conventional APC can explain the survival of these autoreactive T cells.
Structural MRI changes in traumatic brain injury: Comparison of Pre- and post-injury scan results (1992)

Journal Article Structural MRI changes in traumatic brain injury: Comparison of Pre- and post-injury scan results Get access S.E. Macnamara, S.E. Macnamara LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar E.D. Bigler, E.D. Bigler LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Blatter, D. Blatter LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Pompa, J. Pompa LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Ryser, D. Ryser LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar S.M. Kurth S.M. Kurth LDS Hospital and Brigham Young University Search for other works by this author on: Oxford Academic PubMed Google Scholar Archives of Clinical Neuropsychology, Volume 7, Issue 4, 1992, Page 346, https://doi.org/10.1093/arclin/7.4.346 Published: 01 July 1992
Tuning of phase locked loop for industrial regenerative motor-drive systems (2013)

Regenerative motor-drive systems are utilized in several industrial applications that require frequent power generation back to the grid. In these applications, the standard front-end diode bridge commonly used in non-regenerative drives is replaced by an Active Front End “AFE” power converter. The main advantages of the AFE are that it can regenerate power back to the grid, and provide unity power factor operation with a very low total harmonic distortion. The phase locked loop “PLL” is one of the most critical control subsystems in any industrial regenerative motor-drive system. It provides the control of the front-end power converter an accurate knowledge of the utility angle and frequency to ensure proper operation of the whole control algorithm. In this paper, a detailed control analysis and tuning guidelines are presented for the PLL with an adaptive filter under several practical grid steady state and transient conditions.
Enabling limited traffic scheduling in asynchronous ad hoc networks (2005)

We present work-in-progress developing a communication framework that addresses the communication challenges of the decentralized multihop wireless environment. The main contribution is the combination of a fully distributed, asynchronous power save mechanism with adaptation of the timing patterns defined by the power save mechanism to improve the energy and bandwidth efficiency of communication in multihop wireless networks. The possibility of leveraging this strategy to provide more complex forms of traffic management is explored.