gebhart/patrepeval huggingface dataset:
Fast, Cell‐Compatible Click Chemistry with Copper‐Chelating Azides for Biomolecular Labeling (2012)

Kupfer-chelatisierende Azide reagieren unter biokompatiblen Bedingungen sehr viel schneller in Klick-Reaktionen (CuAAC) als nichtchelatisierende Azide. Damit gelingt es, Proteine an der Oberfläche lebender Zellen mit nur 10–40 μM CuI/CuII ortsspezifisch zu markieren (siehe Schema). Auch die Empfindlichkeit für den CuAAC-basierten Nachweis Alkin-modifizierter Proteine und RNA wird gesteigert. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dynamics of intersystem crossing processes in solution for six-coordinate d5, d6, and d7 spin-equilibrium metal complexes of iron(III), iron(II), and cobalt(II) (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of intersystem crossing processes in solution for six-coordinate d5, d6, and d7 spin-equilibrium metal complexes of iron(III), iron(II), and cobalt(II)Eric V. Dose, Mitchell A. Hoselton, Norman Sutin, Michael F. Tweedle, and Lon J. WilsonCite this: J. Am. Chem. Soc. 1978, 100, 4, 1141–1147Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ja00472a017https://doi.org/10.1021/ja00472a017research-articleACS PublicationsRequest reuse permissionsArticle Views529Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Porphinato Zinc Complexes Incorporated into the Bilayer Membrane of Lipid Liposomes (1989)

Abstract 3,8,13,17-Tetramethyl-7,12-divinyl-2,18-bis(18-hydroxyoctadecyl propionate) porphinato zinc (BHPZn) and a model compound, dimethyl ester of protoporphinato zinc (DMPZn), were synthesized and incorporated into the hydrophobic region of bilayer membrane of dipalmitoylphosphatidylcholine (DPPC) liposome. The introduction of long alkyl groups onto the porphyrin ring is effective for restriction of porphyrin aggregation in the bilayer membrane of DPPC liposome. When the molar ratio of DPPC lipid to porphyrin is above 100, the spectrum of BHPZn in the liposome suggests that it is in a typically monomeric state. Quenching of BHPZn fluorescence in the hydrophobic bilayer membrane by hydrophilic quenchers is slow and shows smaller Stern-Volmer constants, while the quenching by hydrophobic quenchers shows much larger Stern-Volmer constants than that of the model compound, DMPZn. These results suggest that the location of the porphyrin ring of BHPZn is fixed at a certain depth in the hydrophobic bilayer membrane of DPPC liposome, and that that of DMPZn is widely distributed in the whole hydrophobic region.
Study on TBC damage process subjected to cyclic irradiation due to CO<sub>2</sub> Laser. (2019)

Thermal barrier coating (TBC) is generally applied to the surface of gas turbine blade in order to protect from a high-temperature combustion gas flow. However, the ceramic top coating (TC) of TBC is cracked and delaminated by thermal cyclic loading resulting from start and stop operation. In this study, the rapid thermal cycling device based on a laser irradiation was developed to appropriately produce the actual thermal cyclic condition. The cylindrical TBC specimens were exposed under a rapid thermal cyclic loading using this device. As a result, a sintered layer was formed in the vicinity of the surface of TC. In addition, both vertical and horizontal cracks were initiated and propagated in the TC. Finally, it was discussed about mechanical factor for those damages through the finite element analysis with the TBC model taking into account a sintering process.
Solid Rheological Properties of PBT-Based Vitrimers (2021)

We present an experimental investigation of the mechanical properties of solid vitrimer samples obtained by incorporating a diepoxide into commercial poly(butylene terephthalate) (PBT) in the presence of a Zn(II) catalyst using batch compounder and injection-molding machines. Tensile experiments were carried out at different temperatures (80, 120, and 160 °C) below the melting point (220 °C) and with various diepoxide concentrations (0, 1, and 2 wt %). We found that vitrimer plastic deformation mechanisms differ drastically from those of the PBT precursor and more generally from the regular behavior of other semi-crystalline polymers. In PBT vitrimers, strain localization (necking) is very weak and can even be suppressed. This type of behavior is due to the increase in strain hardening caused by vitrimer cross-linking. The creep resistance and stiffness of PBT vitrimers are significantly higher than those of pristine PBT. We found that vitrimer modification of PBT at moderate levels improves dimensional stability without inducing brittleness. These promising results highlight the need to find processes which enable significant production levels of these new materials. In the Perspective section, we briefly present a method to produce PBT-based vitrimers using continuous reactive extrusion.
New chiral auxiliary for asymmetric thermal reactions: high regio- and .beta.-stereoselectivity in asymmetric radical addition reactions to mixed fumarimides (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew chiral auxiliary for asymmetric thermal reactions: high regio- and .beta.-stereoselectivity in asymmetric radical addition reactions to mixed fumarimidesJeffrey G. Stack, Dennis P. Curran, Julius Rebek Jr., and Pablo BallesterCite this: J. Am. Chem. Soc. 1991, 113, 15, 5918–5920Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ja00015a088https://doi.org/10.1021/ja00015a088research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate (2007)

We investigated the prevalence of mutations in the PHD finger protein 8 (PHF8) gene in X-linked mental retardation (XLMR) and facial cleft starting from the original cohort of 7712 patients operated on since 1 January 1950 for cleft lip/cleft palate in the Cleft Centre at the Helsinki University Hospital. From this nationwide material, 18 patients including one family with two male patients with cleft lip/cleft palate and unknown cause of mental retardation (MR) were sequenced for the coding regions and splice sites of the PHF8 gene. A novel missense mutation c.836C>T of the PHF8 gene was identified in a Finnish family with multiple-affected male patients. The mutation resides in exon 8 and changes phenylalanine to serine (F279S) in the functionally important Jmonji C domain of the protein. The clinical phenotype of the male patients was characterized by mild MR, mild dysmorphic features, unilateral cleft lip and cleft palate in one and bilateral cleft lip and cleft palate in the other sibling. The mutation was not present in 200 anonymous blood donors (approximately 300 X-chromosomes). To our knowledge, F279S is the third mutation of the PHF8 gene identified so far.
Highly Selective Chlorosulfonation of Tris(pentafluorophenyl)corrole as a Synthetic Tool for the Preparation of Amphiphilic Corroles and Metal Complexes of Planar Chirality (2001)

[reaction: see text]. The chlorosulfonation of tris(pentafluorophenyl)corrole proceeds with an extremely high selectivity as to afford one out of 139 possible isomers in very high yield. The bis-chlorosulfonated corrole is an excellent precursor to the planar-chirality (triphenylphosphine)cobalt(III) complex (fully characterized by X-ray crystallography) and to the amphiphilic bis-sulfonic acid derivative, both the first of their kind.
Highly Conjugated Bis(benzo[b]phosphole)‐P‐oxides: Synthesis and Electrochemical, Optical, and Computational Studies (2022)

Abstract The first examples of a π‐conjugated benzo[ b ]phosphole P ‐oxide in which two phosphole P ‐oxide units are connected by a carbon‐carbon double bond are described. The molecules are synthesized as E isomers with respect to the carbon‐carbon double bond and exist as stable cis and trans isomers (chiral and meso one respectively) relatively to the two stereogenic P atoms. The optical and electrochemical properties of both isomers have been investigated by experiment and computations.
Tuning the Acid/Metal Balance of Carbon Nanofiber‐Supported Nickel Catalysts for Hydrolytic Hydrogenation of Cellulose (2012)

Carbon nanofibers (CNFs) are a class of graphitic support materials with considerable potential for catalytic conversion of biomass. Earlier, we demonstrated the hydrolytic hydrogenation of cellulose over reshaped nickel particles attached at the tip of CNFs. The aim of this follow-up study was to find a relationship between the acid/metal balance of the Ni/CNFs and their performance in the catalytic conversion of cellulose. After oxidation and incipient wetness impregnation with Ni, the Ni/CNFs were characterized by various analytical methods. To prepare a selective Ni/CNF catalyst, the influences of the nature of oxidation agent, Ni activation, and Ni loading were investigated. Under the applied reaction conditions, the best result, that is, 76 % yield in hexitols with 69 % sorbitol selectivity at 93 % conversion of cellulose, was obtained on a 7.5 wt % Ni/CNF catalyst prepared by chemical vapor deposition of CH(4) on a Ni/γ-Al(2)O(3) catalyst, followed by oxidation in HNO(3) (twice for 1 h at 383 K), incipient wetness impregnation, and reduction at 773 K under H(2). This preparation method leads to a properly balanced Ni/CNF catalyst in terms of Ni dispersion and hydrogenation capacity on the one hand, and the number of acidic surface-oxygen groups responsible for the acid-catalyzed hydrolysis on the other.
HeLayers: A Tile Tensors Framework for Large Neural Networks on Encrypted Data (2020)

Privacy-preserving solutions enable companies to offload confidential data to third-party services while fulfilling their government regulations. To accomplish this, they leverage various cryptographic techniques such as Homomorphic Encryption (HE), which allows performing computation on encrypted data. Most HE schemes work in a SIMD fashion, and the data packing method can dramatically affect the running time and memory costs. Finding a packing method that leads to an optimal performant implementation is a hard task. We present a simple and intuitive framework that abstracts the packing decision for the user. We explain its underlying data structures and optimizer, and propose a novel algorithm for performing 2D convolution operations. We used this framework to implement an HE-friendly version of AlexNet, which runs in three minutes, several orders of magnitude faster than other state-of-the-art solutions that only use HE.
Spiroligozymes for Transesterifications: Design and Relationship of Structure to Activity (2012)

Transesterification catalysts based on stereochemically defined, modular, functionalized ladder-molecules (named spiroligozymes) were designed, using the "inside-out" design strategy, and mutated synthetically to improve catalysis. A series of stereochemically and regiochemically diverse bifunctional spiroligozymes were first synthesized to identify the best arrangement of a pyridine as a general base catalyst and an alcohol nucleophile to accelerate attack on vinyl trifluoroacetate as an electrophile. The best bifunctional spiroligozyme reacted with vinyl trifluoroacetate to form an acyl-spiroligozyme conjugate 2.7 × 10(3)-fold faster than the background reaction with a benzyl alcohol. Two trifunctional spiroligozymes were then synthesized that combined a urea with the pyridine and alcohol to act as an oxyanion hole and activate the bound acyl-spiroligozyme intermediate to enable acyl-transfer to methanol. The best trifunctional spiroligozyme carries out multiple turnovers and acts as a transesterification catalyst with k(1)/k(uncat) of 2.2 × 10(3) and k(2)/k(uncat) of 1.3 × 10(2). Quantum mechanical calculations identified the four transition states of the catalytic cycle and provided a detailed view of every stage of the transesterification reaction.
Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level (2008)

New gene expressed in prostate (NGEP) is a prostate-specific polytopic membrane protein found at high concentrations at cell:cell contact regions. To determine if NGEP is a useful target for antibody-based therapy of prostate cancer, we performed an immunohistochemical analysis of 126 human prostate carcinoma samples using polyclonal anti-NGEP sera and found that 91% of the cancers express NGEP protein. To elucidate the topology of NGEP and guide the development of monoclonal antibodies (mAb) reacting with the extracellular regions of NGEP, a hemagglutinin epitope tag was inserted at several positions within the NGEP sequence. The tagged proteins were expressed in 293T cells and locations of the tags were determined by immunofluorescence in intact or permeabilized cells. The results indicate that NGEP contains eight transmembrane domains with both the NH(2) and COOH termini of NGEP located inside the cell. We produced mAb to three regions that are predicted to be intracellular based on the epitope tag data (amino acids 1-352, 441-501, and 868-933), and as predicted, the mAb only detected the protein in permeabilized cells. NGEP is a glycoprotein with predicted glycosylation sites at N809 and N824. When these residues were converted to glutamine, glycosylation was abolished, confirming that the residues are extracellular. Our findings on the expression and the orientation of the NGEP protein serve as an important framework for the development of mAb targeting the extracellular regions of NGEP that could be used for prostate cancer immunotherapy.
Optical gain-bandwidth product of vertical-cavitylaser amplifiers (2001)

Trade-off between amplifier gain and optical bandwidth is investigated in the case of novel long-wavelength vertical-cavity semiconductor optical amplifiers. In agreement with measurements, simple formulas for the gain-bandwidth product are presented. Mirror optimisation promises gain-bandwidth products in the THz range.
Histological and Molecular Evaluation of Patient-Derived Colorectal Cancer Explants (2012)

Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided important information with regard to the mechanisms underlying the oncogenic process, tumor xenograft models remain the standard for the evaluation of new chemotherapy and targeted drug treatments for clinical use. However, it remains unclear to what extent explanted colorectal tumor tissues retain inherent pathological features over time. In this study, we have generated a panel of 27 patient-derived colorectal cancer explants (PDCCEs) by direct transplantation of human colorectal cancer tissues into NOD-SCID mice. Using this panel, we performed a comparison of histology, gene expression and mutation status between PDCCEs and the original human tissues from which they were derived. Our findings demonstrate that PDCCEs maintain key histological features, basic gene expression patterns and KRAS/BRAF mutation status through multiple passages. Altogether, these findings suggest that PDCCEs maintain similarity to the patient tumor from which they are derived and may have the potential to serve as a reliable preclinical model that can be incorporated into future strategies to optimize individual therapy for patients with colorectal cancer.
The VINITI RAS structural database in chemistry. Acquisition, operation and design of information products (2022)

The authors describe the Structural Database (SD) in chemistry supported by the All-Russian Institute of Scientific and Technical Information of the Russian Academy of Sciences (VINITI RAS). The SD history, content, data formats and software are characterized in brief. The database development technologies based exclusively on digital media, are described. The techniques and software for adapting SD retrocollections to advanced software are discussed. The SD products are characterized, i. e. online structured search system, autonomous structured search system, autonomous system for chemical reaction search, e-dictionary of named reactions. The advantage of autonomous systems for searching chemical structures and reactions is that they can be installed on PCs. The SD-based information products can be used in fundamental and applied chemical studies, in chemical industry, education, and in information support of databases, sci-tech libraries and publishers’. The SD array may be applied in the studies based on the vast amount of factual information.
Response characteristics of trapping loss in acoustic charge transport devices (1992)

A model of the response characteristics of trapping loss in acoustic charge transport (ACT) devices on GaAs is presented. Through the use of a computer simulation of the interactions of signal electrons with traps, the model can be used to predict the time or frequency domain responses of the device for arbitrary signal waveforms and various trap distributions. The analysis procedures are discussed in detail for two cases of interest in normal ACT operation, namely, the cases of periodic pulse and single-frequency sinusoidal input signals. For these cases, the predicted dependences of the pulse degradation and frequency response, respectively, on the trap characteristics are presented. The predicted responses are compared to experimental results and to predictions from a previous analytical model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Audio-Visual Class Association Based on Two-stage Self-supervised Contrastive Learning towards Robust Scene Analysis (2023)

This paper proposes a novel audio and visual class association method based on contrastive learning that can obtain not only one-to-one but also one-to-many, many-to-many, and even no correspondence between audio and visual classes. The proposed method consists of two training stages. In the first stage, for “correspondence” training, using self-supervised contrastive learning, one-to-one, one-to-many, and many-to-many correspondences are trained under a criterion that corresponding AV pairs become close and non-corresponding pairs are far. In the second stage, for “non-correspondence” training, those relationships are acquired through contrastive learning using a dataset consisting of pairs of visual and audio classes that have no correspondence. To build such a dataset, we utilize the trends of change in the class embeddings and split a set of all the classes into two subsets, with AV correspondence and without AV correspondence. The trained model with the proposed method was evaluated by the F1-score for the class embedding, and indoor experiment on mapping of two sound sources. As a result, the F1-score was 74.7% after the first stage, and it improved by 1.86 points to 76.6% after the second stage, confirming, the proposed method is effective for mapping between general audio and visual classes, including one-to-many, many-to-many, and non-corresponding classes. Indoor experiment revealed that our model could predict correct correspondence even in real environment.
Spacetime division multiple access (SDMA) for mobile, multihop, broadcast packet radio networks (2002)

Many transmission-scheduling algorithms have been proposed to maximize the spatial reuse and minimize the time-division multiple-access (TDMA) frame length in multihop packet radio networks. None of these algorithms uses knowledge of the physical location. We propose a new concept. Spacetime division multiple access. In spacetime division multiple access (SDMA), space is divided into slots (space slots) that are grouped into periodically repenting frames (space frames), and time slots are assigned to space slots (hence, spacetime). The space slots are constructed such that the probability of more than one node being in the same space slot is minimized, and the space frame is constructed such that spatial reuse is minimized, thus minimizing the TDMA frame length. Therefore, given that each node in the network has a means of determining its location, all nodes can instantaneously determine at all times, the time slot that they should transmit at, without exchanging any information with any other node in the network. Next, we derive the time frame length for mobile, multi-hop, broadcast packet radio networks using SDMA, as a function of the network density and the maximum transmission range. Finally, we show how SDMA can be utilized as the access scheme for the control channel of a reservation TDMA MAC protocol.