210 LOSS OF CHROMOSOME 3P IN CLEAR CELL RENAL CELL CARCINOMA – ARE THERE DIFFERENCES ACCORDING TO THE UNDERLYING ABERRATION? (2010)

You have accessJournal of UrologyKidney Cancer: Basic Research II1 Apr 2010210 LOSS OF CHROMOSOME 3P IN CLEAR CELL RENAL CELL CARCINOMA – ARE THERE DIFFERENCES ACCORDING TO THE UNDERLYING ABERRATION? Tobias Klatte, Nagesh Rao, Michela de Martino, Brian Shuch, Nazy Zomorodian, Jonathan Said, Fairooz Kabbinavar, Arie Belldegrun, and Allan Pantuck Tobias KlatteTobias Klatte More articles by this author , Nagesh RaoNagesh Rao More articles by this author , Michela de MartinoMichela de Martino More articles by this author , Brian ShuchBrian Shuch More articles by this author , Nazy ZomorodianNazy Zomorodian More articles by this author , Jonathan SaidJonathan Said More articles by this author , Fairooz KabbinavarFairooz Kabbinavar More articles by this author , Arie BelldegrunArie Belldegrun More articles by this author , and Allan PantuckAllan Pantuck More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.267AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Loss of chromosome 3p material and subsequent loss of the von Hippel-Lindau tumor suppressor gene have been observed in about 50% of clear cell renal cell carcinomas and have been identified as a favorable prognostic factor. However, several aberrations can lead to loss of 3p material, including deletions, translocations, and inversions. The aim of this study was to assess the biologic impact of the different aberrations leading to loss of 3p. METHODS We prospectively studied 246 consecutive patients who underwent nephrectomy for clear cell RCC at our institution. For cytogenetic analysis, viable tumor samples were collected immediately after surgery, short-term cultured and analyzed by using the GPG banding technique. The endpoint was disease-specific survival. RESULTS Loss of 3p material was observed in 147 tumors (60%). There were 90 deletions (61%), 50 translocations (34%) and 7 inversions (5%). Tumors with loss of 3p displayed lower TNM stages and a lower frequency of sarcomatoid features than tumors without loss of 3p. There was no difference in distribution of TNM stage (p=0.336) or grade distribution (p=0.179) among the different aberrations. In univariate analysis, loss of 3p material was associated with a more favorable prognosis (p=0.028), however, among those with loss of 3p, there was no difference according to the type of aberration (p=0.541). In multivariate analysis, neither loss of 3p (p=0.779) nor the type of aberration (p=0.870) was identified as independent prognostic factor. CONCLUSIONS Loss of chromosome 3p material is associated with a more favorable prognosis among patients with clear cell renal cell carcinoma. However, the type of aberration leading to loss of 3p does not impact tumor biology. Loss of the von Hippel-Lindau tumor suppressor appears to be the crucial event in carcinogenesis, regardless of the underlying mechanism. Los Angeles, CA© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e83 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tobias Klatte More articles by this author Nagesh Rao More articles by this author Michela de Martino More articles by this author Brian Shuch More articles by this author Nazy Zomorodian More articles by this author Jonathan Said More articles by this author Fairooz Kabbinavar More articles by this author Arie Belldegrun More articles by this author Allan Pantuck More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...