gebhart/patrepeval huggingface dataset:
Ionizing Radiation Response of GaAs JFETs and DCFL Circuits (1982)

Transient responses and logic upset threshold dose rates of planar, all-ion implanted GaAs E-JFETs and DCFL (= direct-coupled field-effect transistor logic) integrated circuits to ionizing radiation pulses of 20 ns duration from a LINAC are reported. It is experimentally verified that the logic upset dose rate of enhancement mode GaAs JFET integrated circuits is inversely proportional to the square of their channel length. For L = 1 μm a theoretical value of γUPSET = 1.175 × 1011 rad (GaAs)/s is predicted and medium scale integrated circuits have confirmed this value with experimental results in the range of 5 × 1010 to 1 × 1011 rad (GaAs)/s. A theoretical relation for logic upset dose rate and a correlation of experimental results with theory is presented. Long term conductance transients are not inherent to E-JFET inverters with resistive and depletion mode JFET load, but are present in source-follower circuits. A model for this circuit behavior will be presented.
Chemistry of bent bonds. XXXVI. Photolysis of substituted derivatives of 2,3-diazabicyclo[3.1.0]hex-2-ene. Simple route to certain bicyclo[1.1.0]butanes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of bent bonds. XXXVI. Photolysis of substituted derivatives of 2,3-diazabicyclo[3.1.0]hex-2-ene. Simple route to certain bicyclo[1.1.0]butanesPaul G. Gassman and William J. GreenleeCite this: J. Am. Chem. Soc. 1973, 95, 3, 980–982Publication Date (Print):February 1, 1973Publication History Published online1 May 2002Published inissue 1 February 1973https://pubs.acs.org/doi/10.1021/ja00784a089https://doi.org/10.1021/ja00784a089research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Removal of Bromate from Water Using De‐Acidite FF‐IP Resin and Determination by Ultra‐Performance Liquid Chromatography‐Tandem Mass Spectrometry (2013)

Abstract Contamination of water due to bromate is a severe health hazard. The aim of the present study was to remove bromate from water using a crosslinked polystyrene based strongly basic anion exchange resin De‐Acidite FF‐IP. Batch experiments were performed to study the influence of various experimental parameters such as effect of pH, contact time, temperature, and effect of competing anions on bromate removal by De‐Acidite FF‐IP resin. At optimum parameters, the removal rate of bromate was very fast and 90% removal took place in 5 min and equilibrium was established within 10 min. The presence of competitive anions reduced the bromate adsorption in the order of Cl − &gt; F − &gt; CO &gt; SO &gt; NO &gt; PO . The practical utility of this resin has been demonstrated by removing bromate in some of the commercial bottled water from Saudi Arabia. The level of bromate was determined using a very sensitive, precise and rapid method based on ultra‐performance liquid chromatography‐tendem mass spectrometry (UPLC‐MS/MS).
Wireless Collaboration (2010)

To achieve performance gains in the wireless channel, spatial diversity is employed. These higher order transmit diversity gains generally require multiple transmit antennas at the source. This requirement is not always possible in real world applications, where practical concerns limit the number of antennas a wireless device can have. Recently, a new method to achieve transmit diversity has been proposed: collaborative communications. In this framework, a node in a wireless network can use the resources of other idle nodes and form what can be viewed as a virtual transmitting antenna array. This chapter presents an overview of the development of collaborative communications. Two-phase protocols that can achieve collaboration are presented. A discussion on the improvement of collaborative communications protocols is given. A broader perspective of collaborative communications is given by discussing ideas such as power allocation and multiple relays.
Optisch aktive Übergangsmetall‐Komplexe, XIII. Optisch aktive Azomethin‐Derivate von Tricarbonyl‐(cyclopentadienyl)molybdän‐ und ‐wolframchlorid (1972)

Abstract Die Umsetzungen der Schiffschen Basen von Pyridin‐2‐carbaldehyd 5a – e mit den Tricarbonyl(cyclopentadienyl)chloriden von Molybdän 6 und Wolfram 7 ergeben kationische Komplexe mit asymmetrischen Metallatomen. Die Verbindungen können in Form der Chloride 8 und 9 bzw. der Hexafluorophosphate 10 und 11 isoliert werden. Die IR‐ und Elektronenspektren der neuen Verbindungen sind angegeben. Im 1 H‐NMR‐Spektrum erweisen sich die Methylgruppen der Isopropyl‐Verbindung 10b als diastereotop. (–)‐1‐Phenyläthylamin als Aminkomponente in den Azomethin‐Komplexen 10e und 11e führt zum Auftreten diastereomerer Formen, die durch fraktionierte Kristallisation getrennt werden können. Die neuen optisch aktiven Verbindungen 12 – 15 zeichnen sich durch hohe Stabilität der tetragonal‐pyramidalen Konfiguration aus.
Evaluation of a Telephone Version for the Montreal Cognitive Assessment: Establishing a Cutoff for Normative Data From a Cross-Sectional Study (2021)

Objective: Compare a telephone version and full version of the Montreal Cognitive Assessment (MoCA). Methods: Cross-sectional analysis of a prospective study. A 20-point telephone version of MoCA (Tele-MoCA) was compared to the Full-MoCA and Mini Mental State Examination. Results: Total of 140 participants enrolled. Mean scores for language were significantly lower with Tele-MoCA than with Full-MoCA (P = .003). Mean Tele-MoCA scores were significantly higher for participants with over 12 years of education (P &lt; .001). Cutoff score of 17 for the Tele-MoCA yielded good specificity (82.2%) and negative predictive value (84.4%), while sensitivity was low (18.2%). Conclusions: Remote screening of cognition with a 20-point Tele-MoCA is as specific for defining normal cognition as the Full-MoCA. This study shows that telephone evaluation is adequate for virtual cognitive screening. Our sample did not allow accurate assessment of sensitivity for Tele-MoCA in detecting MCI or dementia. Further studies with representative populations are needed to establish sensitivity.
(150) Outcome Assessment of Resident Instruction: The Colorado State University Experience (2005)

An assessment plan for the Horticulture and Landscape Horticulture majors has been developed as part of a university-wide effort to assess resident instruction. The program mission has been described as the preparation of graduates with a passion for Horticulture/Landscape Horticulture who can contribute to Colorado's agricultural and green industry economy through high levels of: 1) technical competency and skills, including disciplinary competence, and a working knowledge in the appropriate field; 2) management and leadership skills; and 3) problem-solving skills. Assessment methods involved the development of evaluation forms for internships, practicum, independent study, group study, and the capstone courses. Student, faculty, clients, and industry personnel used standardized forms, which varied somewhat for the two majors and seven concentrations, to critically assess and score student and faculty efforts. Internships, practicum, and capstone courses were evaluated for program purpose. The management and leadership skills of the students were evaluated based on their performance during internships by cooperators and also by their activities, as demonstrated through their involvement in university, college, departmental, and community activities. Problem-solving skills were evaluated primarily through student performance in capstone courses, with specific criteria in the internship and in leadership activities of clubs. The expectation is that 70% to 75% of the students will score 3 or 3+ on all criteria established for a rating system of 1–5. Students have generally met this standard and plans are under way to continually upgrade courses and related activities to improve the teaching program
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency (2017)

Lipids are essential components of the nervous system. However, the functions of very long-chain fatty acids (VLC-FA; ≥ 28 carbons) in the brain are unknown. The enzyme ELOngation of Very Long-chain fatty acids-4 (ELOVL4) catalyzes the rate-limiting step in the biosynthesis of VLC-FA (Agbaga et al., Proc Natl Acad Sci USA 105(35): 12843-12848, 2008; Logan et al., J Lipid Res 55(4): 698-708, 2014), which we identified in the brain as saturated fatty acids (VLC-SFA). Homozygous mutations in ELOVL4 cause severe neuropathology in humans (Ozaki et al., JAMA Neurol 72(7): 797-805, 2015; Mir et al., BMC Med Genet 15: 25, 2014; Cadieux-Dion et al., JAMA Neurol 71(4): 470-475, 2014; Bourassa et al., JAMA Neurol 72(8): 942-943, 2015; Aldahmesh et al., Am J Hum Genet 89(6): 745-750, 2011) and are post-natal lethal in mice (Cameron et al., Int J Biol Sci 3(2): 111-119, 2007; Li et al., Int J Biol Sci 3(2): 120-128, 2007; McMahon et al., Molecular Vision 13: 258-272, 2007; Vasireddy et al., Hum Mol Genet 16(5): 471-482, 2007) from dehydration due to loss of VLC-SFA that comprise the skin permeability barrier. Double transgenic mice with homozygous knock-in of the Stargardt-like macular dystrophy (STDG3; 797-801_AACTT) mutation of Elovl4 with skin-specific rescue of wild-type Elovl4 expression (S <sup>+</sup> Elovl4 <sup>mut/mut</sup> mice) develop seizures by P19 and die by P21. Electrophysiological analyses of hippocampal slices showed aberrant epileptogenic activity in S <sup>+</sup> Elovl4 <sup>mut/mut</sup> mice. FM1-43 dye release studies showed that synapses made by cultured hippocampal neurons from S <sup>+</sup> Elovl4 <sup>mut/mut</sup> mice exhibited accelerated synaptic release kinetics. Supplementation of VLC-SFA to cultured hippocampal neurons from mutant mice rescued defective synaptic release to wild-type rates. Together, these studies establish a critical, novel role for ELOVL4 and its VLC-SFA products in regulating synaptic release kinetics and epileptogenesis. Future studies aimed at understanding the molecular mechanisms by which VLC-SFA regulate synaptic function may provide new targets for improved seizure therapies.
The impact of PMD on nonlinear interchannel crosstalk in DWDM transoceanic systems (2002)

The impact of PMD coupled with nonlinear interaction in long-haul DWDM system was numerically studied. We show that in certain regimes of channel spacing and PMD, orthogonal launch of adjacent channels provides significant performance improvement.
Photophysical Properties of Thermally Activated Delayed Fluorescent Materials upon Distortion of Central Axis of Donor Moiety (2018)

In this study, we showed the distortion of the central axis of the donor moiety can switch critically the rate of the reverse intersystem crossing (kRISC) process, which is the trigger point to modulate the lifetime of delayed fluorescence. To achieve kRISC, what we desired (105 to 106 s–1) in a series of donor–acceptor–donor (D–A–D) type thermally activated delayed fluorescence (TADF) materials, the donor groups (phenoxazine and phenothiazine) were selectively introduced. Maintaining the near orthogonality between donor and acceptor (benzonitrile) moiety, the occurrence of the distortion of the central axis of the donor moiety could make the effect of locally excited triplet state (3LE). In other words, the interaction between 3LE and the charge transfer counterparts (i.e., 1CT and 3CT) contributes an opposite propensity of kRISC for each of the target TADF materials when those are dissolved in solution and condensed in solid state. Herein, we have theoretically and experimentally shown the photophysical behavior of common D–A–D type TADF upon the different systems.
Transparent Interconnection of Lots of Links (TRILL): Adjacency (2014)

The IETF Transparent Interconnection of Lots of Links (TRILL) protocol
supports arbitrary link technologies between TRILL switches, including
point-to-point links and multi-access Local Area Network (LAN) links
that can have multiple TRILL switches and end stations attached. TRILL
uses Intermediate System to Intermediate System (IS-IS) routing. This
document specifies the establishment, reporting, and termination of
IS-IS adjacencies between TRILL switches, also known as RBridges
(Routing Bridges). It also concerns four other link-local aspects of
TRILL: Designated RBridge (DRB) selection, MTU (Maximum Transmission
Unit) testing, pseudonode creation, and BFD (Bidirectional Forwarding
Detection) session bootstrapping in connection with adjacency. State
diagrams are included where appropriate. This document obsoletes RFC
6327 and updates RFC 6325.
Terthienyl and Poly-terthienyl Ligands as Redox-Switchable Hemilabile Ligands for Oxidation-State-Dependent Molecular Uptake and Release (2001)

Mononuclear, dinuclear, and polymeric Ru(II) complexes formed from terthienylalkylphosphino redox-switchable hemilabile ligands demonstrate that this class of ligand provides electrochemical control over the electronic properties, coordination environments, and reactivities of bound transition metals. Specifically, [CpRuCO(kappa(2)-3'-(2-diphenylphosphinoethyl)-5,5' '-dimethyl-2,2':5',2' '-terthiophene)][B(C(6)H(3)-3,5-(CF(3))(2))(4)] (4a) exhibits a 3 orders of magnitude increase in binding affinity for acetonitrile upon terthienyl-based oxidation. FT-IR spectroelectrochemical experiments on 4a indicate that terthienyl-based oxidation removes electron density from the metal center, equivalent to approximately 11-17% of the electronic change that occurs upon direct oxidation of Ru(II) to Ru(III) in analogous complexes. The spectroelectrochemical responses of 4a were compared to those of dimeric and polymeric analogues of 4a. The spectroelectrochemistry of the dimer is consistent with two sequential, one-electron ligand-based oxidations, compared to only one in 4a. In contrast, the polymer exhibits spectroelectrochemical behavior similar to that of 4a. The polymer spectroelectrochemistry shows changes in the metal center electronic properties between two different states, reflective of two discrete oxidation states of the polymeric ligand backbone. We propose that the polymer backbone does not allow one to vary the electronic properties of the metal center through a continuous range of oxidation states due to charge localization within the metalated films. In an effort to explore the molecular uptake and release properties of 4a and its polymer analogue as a function of ligand oxidation state, the oxidation-state-dependent coordination chemistries of 4a and 4a(+)() with a variety of substrates were examined.
Effect of amino acids on choline uptake and phosphatidylcholine biosynthesis in the isolated hamster heart (1988)

Choline uptake by the hamster heart has been shown to be enhanced by exogenous glycine. In this study, the effect of neutral, basic, and acidic amino acids on choline uptake was assessed. Hamster hearts were perfused with labelled choline, and in the presence of L-alanine, L-serine, or L-phenylalanine (greater than or equal to 0.1 mM), choline uptake was enhanced 20-38%. L-Arginine, L-lysine, L-aspartate, and L-glutamate did not influence choline uptake. The rate of phosphatidylcholine biosynthesis was unaffected by all amino acids tested. Enhancement of choline uptake by neutral amino acids was not additive or dose dependent but required a concentration threshold. The enhancement of choline uptake by neutral amino acids was not influenced by preperfusion with the same amino acid. Exogenous choline had no effect on the uptake of amino acids. We postulate that choline and the neutral amino acids are not cotransported and modulation of choline uptake is facilitated by direct interaction of the neutral amino acids with the choline transport system.
Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part I (1996)

(R) and (S)-3-aminoquinuclidines-3H with the specific activity of 35 Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritium gas over RhCODCI dimer, (2S, 3S) Chiraphos in methanol gave racemic amide 9c. Hydrolysis followed by resolution of the enantiomers with (R)-methyl benzyl isocyanate gave (R) and (S)-3-aminoquinuclidine-3H 10c-S and 10c-R. The enantiopurity purity of both isomers was >99.5%.
Molecular beam epitaxy HgCdTe infrared photovoltaic detectors (1994)

We present <i>p</i>-on-<i>n</i> heterostructure HgCdTe photovoltaic device data that illustrate the high performance and flexibility in band-gap control of molecular beam epitaxy technology. This flexibility demonstration was performed by growing material for operation in the following cutoff wavelength (λ<sub><i>co</i></sub>) ranges of interest: long wavelength IR (LWIR) [λ<sub><i>co</i></sub>(77 K) = 9 to 11 μm], mid-long wavelength IR (MLWIR) [λ<sub><i>co</i></sub>(77 K) = 6.8 μm], and very long wavelength IR (VLWIR) [λ<sub><i>co</i></sub>(40 K)=20 μm]. Detailed analyses of the current-voltage characteristics of these diodes as a function of temperature show that their dark currents are diffusion limited down to 80, 50, and 30 K for the MLWIR, LWIR, and VLWIR photodiodes, respectively. In general, the <i>R<sub>0</sub>A</i> device values were uniform for the three band-gap ranges when operating under diffusionlimited conditions. We confirmed this by fabricating a 64 x 64 LWIR (λ<sub><i>co</i></sub> = 10.2 μm) hybrid FPA with detectivity (<i>D*</i>) operability greater than 97% when operating at 77 K. The mean <i>D*</i> value for this device was 1.4 x 10<sup>11</sup> cm Hz<sup>1/2</sup>/W and it was background limited at the tested flux of 2.18 x 10<sup>16</sup> photons/cm<sup>2</sup> s. This device was tested at higher temperatures of operation without changing background conditions, and it remained background limited up to 100 K.
Kaposi’s Sarcoma Associated Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and LUBAC (2012)

Our results demonstrate that K13 activates the NF-κB pathway by binding to NEMO which results in the recruitment of IKK1/IKKα and IKK2/IKKβ and their subsequent activation by phosphorylation. Thus, K13 activates NF-κB via a mechanism distinct from that utilized by inflammatory cytokines. These results have important implications for the development of therapeutic agents targeting K13-induced NF-κB for the treatment of KSHV-associated malignancies.
Loss of prostaglandin F2α, but not thromboxane, responsiveness in pregnant human myometrium during labour (2008)

Prostaglandins (PG) E2, PGF2alpha and thromboxane (TX) mediate uterine contractility by targeting prostonoid EP, FP and TP receptors respectively. The aim of this study was to elucidate the function of these receptors in isolated human myometrium taken at term gestation prior to and following labour onset. Lower segment myometrial strips were immersed in organ baths in oxygenated Krebs' solution at 37 degrees C and connected to isometric force transducers. After equilibration, spontaneous activity and concentration responses to PGE2, PGF2alpha and U46619 (a stable TX mimetic) were measured as area under the curve and expressed as a percentage of the final contraction induced by hypotonic shock. Results were expressed as arithmetic means+/-s.e.m. and analysed using two-way ANOVA with Bonferroni's post hoc test. Myometrium excised at late gestation displayed the greatest spontaneous activity compared with the tissues taken during labour (P<0.001). Excitation evoked by PGF2alpha (P<0.01) and PGE2 at 10(-5) mol/l were attenuated after labour onset. U46619 consistently stimulated concentration-dependent contractions (P<0.001) and selective antagonists confirmed TP-mediated effects. The maintained responses to TX indicate crucial roles for TP receptors in the muscular tonus of the parturient uterus. This receptor and its secondary messenger system represent effective myometrial targets for tocolytic agents in both pregnancy and labour-associated disorders.
Nitromedicine: translating alternative medicine to evidence based medicine and redefining disease(Conference Presentation) (2016)

Nitromedicine is a new medical treatment paradigm, focused on increasing nitric oxide (NO) bioavailability and modulating redox-signaling pathways combined with phototherapy, electrotherapy and stem cell therapy. It has been known since the discovery of the biological role of NO in the 1980s, that supplying NO donors such can have many beneficial effects in different conditions by stimulating stem cells and modulating the immune response, but there also exists a substantial risk of side-effects with long-term use. Excess NO can inhibit mitochondrial metabolism by binding to cytochrome c oxidase (CCO) and can also produce reactive nitrogen species (Peroxynitrite) by interacting with reactive oxygen species (ROS). To avoid these potential damaging side-effects we propose to combine the use of NO donors with three additional components. Firstly we believe that addition of antioxidants such as hydrogen sulfide donors, polyphenols and vitamins can neutralize ROS and RNS. Secondly we believe that application of appropriate wavelengths and dosages of light (blue, red or near infrared depending on the exact condition being treated) will dissociate NO from CCO (and other storage sites) thus restoring mitochondrial ATP production and stimulating healing in many situations. Thirdly delivering electrons to the body might help to saturate the free radicals with electrons, eliminate underlying oxidative stress, stabilize mitochondria, prevent further formation of pathological free radicals and increase the nitric oxide bioavailability. This combination therapy may be applied to treat a large variety of oxidative stressed related diseases such as degenerative diseases, immunological diseases, chronic infectious diseases, cancers and a broad range of unmet medical needs involving chronic inflammation with an emphasis on pain management.
Protein tyrosine phosphatases: regulatory mechanisms (2008)

Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
Actinometric measurements and theoretical calculations of j(O3)the rate of photolysis of ozone to O(¹D) (1979)

A new experimental technique measures j(O 3 ‐O(¹D))the rate of solar photolysis of ozone to singlet oxygen atoms: O 3 + hν → O 2 + O(¹D). A flow actinometer carries dilute O 3 in N 2 O into direct sunlight where the O(¹D) formed reacts with N 2 O to form NO which chemiluminescence detectswith a time resolution on the order of one minute. Measurements indicate a photolysis rate of 1.2 (± .2) × 10 −5 s −1 for a cloudless sky45° zenith angle0.345 cm ozone column and zero albedo. Ground level results (elevation 1.8 km) compare with theoretical calculations based on the UV actinic flux as a function of ozone column and solar zenith angle.