gebhart/patrepeval huggingface dataset:
Track Chair's Report: Convergence of Distributed Clouds, Grids, and Their Management CDCGM 2016 (2016)

This track has made significant contribution to advance the current state of the art in enterprise distributed application management across data centers, and clouds public or private. The scale of distributed applications and their management have taken a new dimension demanding tolerance to wild fluctuations both in workloads and available computing resource pools. A new computing model proposing extensions to the current von Neumann implementation of the Turing machine was contributed by the efforts of participating in this conference since 2009. The result is a practical demonstration of these concepts, showing infrastructure agnostic auto-fail over, auto-scaling and live-migration of even state-sensitive distributed applications. By eliminating virtual image motion which is the current state of the art, this approach improves efficiency and reduces complexity and tool fatigue prevalent in todays enterprises. In addition, a review of the super recursive algorithms and inductive Turing machines in this track provides the theoretical foundation for new computing. In addition, there are five full papers describing advances in current distributed and cloud computing practices dealing with quality of service, adaptive algorithms and software defined network architectures. One short paper discusses a new approach for resource allocation in distributed systems. On the eve of the 25th anniversary of WETICE, this track attests to its success where the work started here has contributed to both theoretical and practical application going from ideation to application within a span of 6 years.
Ozonolysis of α-angelica lactone: a renewable route to malonates (2021)

Industrially relevant intermediates such as malonic acid, malonates and 3-oxopropionates can be easily accessed by ozonolysis of α-angelica lactone, derived from the platform chemical levulinic acid. The roles of the solvent and of the quenching conditions are of key importance for the outcome of the reaction.
Structure and Dynamics of Benzyl-NX3 (X = Me, Et) Trifluoromethanesulfonate Ionic Liquids (2014)

Ammonium-based benzyl-NX3 (X = methyl, ethyl) trifluoromethanesulfonate (TFA) ionic liquids (ILs) are low cost, nontoxic, thermally stable ion-conducting electrolytes in fuel cells and batteries. In the present study, we have characterized the structure and dynamics of these ILs using molecular dynamics (MD) simulations and ionic conductivity using electro-chemical impedance spectroscopy (EIS) at varying temperature and relative humidity (RH). Results from MD simulations predict that cation-cation and cation-anion interactions are stronger in benzyltrimethylammonium (BzTMA) compared to benzyltriethylammonium (BzTEA) that diminish with increase in RH. Further, the BzTMA cations show both C-H/Ph (center of mass of phenyl ring) and cation-Ph interactions whereas BzTEA cations show only strong cation-Ph interactions. The C-H/Ph interactions (ψ ≥ 90°, d(H-Ph) ≤ 4 Å, θ < 50° and d(C-Ph) ≤ 4.3 Å) in BzTMA cations increase with RH and are highest at RH = 90%. The cumulative impact of electrostatic, cation/Ph, and C-H/Ph interactions results in lower conductivity of BzTMA-TFA IL compared to BzTEA-TFA IL. The EIS measurements show that the trends in ionic conductivity of ILs at RH = 30 and 90% are qualitatively similar to the Nernst-Einstein conductivity from MD simulations. The ionic conductivity of BzTEA-TFA IL is ~3 times higher than BzTMA-TFA IL at 353 K and RH = 90%.
Guide to Training Students' Value: Three Representatives (2003)

The main stream of contemporary students' value is healthy, while side effects also exist. Three representatives are the heritage and development of Marxism, and an important guide to training students' value. We shall fulfill its spirit to train the students.
Autophagy and Apoptosis in Hepatocellular Carcinoma Induced by EF25-(GSH)2: A Novel Curcumin Analog (2014)

Curcumin, a spice component as well as a traditional Asian medicine, has been reported to inhibit proliferation of a variety of cancer cells but is limited in application due to its low potency and bioavailability. Here, we have assessed the therapeutic effects of a novel and water soluble curcumin analog, 3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one glutathione conjugate [EF25-(GSH)2], on hepatoma cells. Using the MTT and colony formation assays, we determined that EF25-(GSH)2 drastically inhibits the proliferation of hepatoma cell line HepG2 with minimal cytotoxicity for the immortalized human hepatic cell line HL-7702. Significantly, EF25-(GSH)2 suppressed growth of HepG2 xenografts in mice with no observed toxicity to the animals. Mechanistic investigation revealed that EF25-(GSH)2 induces autophagy by means of a biphasic mechanism. Low concentrations (<5 µmol/L) induced autophagy with reversible and moderate cytoplasmic vacuolization, while high concentrations (>10 µmol/L) triggered an arrested autophagy process with irreversible and extensive cytoplasmic vacuolization. Prolonged treatment with EF25-(GSH)2 induced cell death through both an apoptosis-dependent and a non-apoptotic mechanism. Chloroquine, a late stage inhibitor of autophagy which promoted cytoplasmic vacuolization, led to significantly enhanced apoptosis and cytotoxicity when combined with EF25-(GSH)2. Taken together, these data imply a fail-safe mechanism regulated by autophagy in the action of EF25-(GSH)2, suggesting the therapeutic potential of the novel curcumin analog against hepatocellular carcinoma (HCC), while offering a novel and effective combination strategy with chloroquine for the treatment of patients with HCC.
A Novel Gallium/Samarium‐Mediated Coupling of Epoxides with Allyl Halides in Aqueous Media and Synthesis of Homoallylic Alcohols. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Intraocular pressure rise is predictive of vision improvement after intravitreal triamcinolone acetonide for diabetic macular oedema: a retrospective analysis of data from a randomised controlled trial (2014)

Clinical trials.gov NCT00167518, September 5, 2005.
VARIACIÓN EN EL TIEMPO DE LAS PROPIEDADES FÍSICAS DE UN SUELO CON ADICIÓN DE ENMIENDAS ORGÁNICAS (2003)

La presente investigacion tuvo como objetivo evaluar la potencialidad del bioabono y el estiercol de bovino como agente mejorador de las propiedades fisicas del suelo. El bioabono aplicado provino de un biodigestor tipo Batch, mientras que el estiercol provino de una lecheria. El acondicionamiento del suelo fue realizado en parcelas de 6 x 3 m, con 4 tratamientos y 3 repeticiones. Los tratamientos, en mezcla volumetrica, fueron: testigo sin acondicionar, mezcla de suelo:bioabono en relacion 3:1, mezcla suelo:bioabono en relacion 1:1 y mezcla suelo:estiercol en relacion 1:1. En el segundo ano, las parcelas fueron divididas en dos, generando subparcelas de 6 x 1,5 m, una de las cuales tuvo un segundo acondicionamiento con el mismo material y proporcion. Las evaluaciones se realizaron un mes, un ano y dos anos despues de la primera aplicacion organica. Las propiedades de suelo evaluadas fueron: densidad aparente, densidad real, retencion de agua, velocidad de infiltracion y estabilidad de agregados. Se establecio un cultivo de tuna (Opuntia ficus - indica (L.) Mill.) como planta indicadora. Las aplicaciones de materia organica en grandes volumenes provocaron en el corto plazo una disminucion de la densidad aparente; consecuentemente, aumento la porosidad total, especialmente los poros gruesos (reflejados en la curva pF). La densidad real y el agua aprovechable no presentaron diferencias entre tratamientos, mientras que la infiltracion de agua aumento con la aplicacion de enmiendas. Hubo un incremento de la estabilidad de agregados en el corto plazo, pero con aplicaciones sucesivas el efecto desaparecio. Finalmente, las aplicaciones de bioabono promovieron el desarrollo de brotes y la produccion de MS de la tuna.
STRUCTURAL AND OPTICAL PROPERTIES OF SELF-ASSEMBLED InAs QUANTUM DOTS GROWN ON GaAs(311) A SUBSTRATE (1999)

We report the structural and optical characteristics of InAs quantum dots (QDs) grown on GaAs (311)A substrates. Atomic force microscopic result shows that QDs on (311)A surface exhibit a nonconventional, faceted, arrowhead-like shapes aligned in the [233] direction. The photolumi-nescence (PL) intensity, peak position and the full width at half maxinum (FWHM) are all colsely related to the measurement temperature. The fast redshift of PL energy and monotonous decrease of linewidth with increasing temperature were observed and explained by carriers being thermally activated to the barrier produced by the wetting layer and then being retrapped and recombined in energetically lower-lying QDs states. This model explains our results well.
4.5 kV novel high voltage high performance SiC-FET "SIAFET" (2002)

A novel high voltage SiC MOS device named SIAFET (Static induction Injected Accumulated FET) is proposed, which has no pn junction in its on-current flow path and has a conductivity modulation by carriers injected from a p+ buried gate. SIAFET with blocking voltage (BV) of 5500 V and specific on-resistance RonS (without the conductivity modulation) of 57 m/spl Omega/cm/sup 2/ was designed by using the 6200 V mesa JTE and was fabricated using 4H-SiC substrates. Its basic operation has been confirmed for the first time and it has been demonstrated that its RonS has been shown to reduce to less than 1/6 by SIAFET action. Although its achieved BV is relatively low (2030 V and 4580 V) and its RonS is relatively high (172 m/spl Omega/cm/sup 2/ and 387 m/spl Omega/cm/sup 2/), RonS of 4580 V SiC-SIAFET is less than 1/25 that of the theoretical RonS limit of Si-MOSFET for this BV.
Short duration exercise increases breath hydrogen excretion after lactulose ingestion: description of a new phenomenon (2002)

This study demonstrates that exercise potentially enhances the metabolism of lactulose by colonic bacteria. The authors postulate that this effect is due to stirring of the colonic contents. The described phenomenon may explain, in part, the beneficial effects of exercise on colonic mucosa.
Exponential growth of backward-wave phonon echoes (1984)

A recent paper by Gaumond and Jacobsen analyzed the process of backward-wave, phonon-echo generation in an insulator in terms of solutions of Mathieu's equation. We discuss the experimental conditions under which the predictions of their analysis would be expected to hold, and we report the observation of exponential growth of the echo amplitudes in LiNb${\mathrm{O}}_{3}$.
A Catch-and-Release drive MEMS gyroscope with enhanced sensitivity by mode-matching (2017)

This paper presents a novel MEMS gyroscope that employs intermittent free vibration and mode matching. An intermittent operation is realized by a “Catch-and-Release (CR)” technique, which enables significant reduction of the drive power. Sensitivities of the mode-matching and mode-split conditions are investigated by electrostatically tuning the sense-mode frequency. A sensitivity as high as 2.14 mV/dps, 52 times higher than the mode-split case, is obtained when the drive and sense frequency difference Δf is reduced to 50 Hz. Optimization for mode matching and quadrature nulling is also demonstrated.
Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog (2023)

A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole known as KRM-II-81) is currently awaiting advancement into the clinic. A deuterated structural analog (D5-KRM-II-81) was made as a potential backup compound and studied here in comparison to KRM-II-81. In the present study, both compounds significantly prevented seizures in mice induced by 6 Hz (44 mA) electrical stimulation without significantly altering motoric function on a rotarod after intraperitoneal administration. Both compounds also significantly prevented clonic seizures, tonic seizures, and lethality induced by pentylenetetrazol in mice when given orally. D5-KRM-II-81 had a slightly longer duration of action against clonic and tonic seizures than KRM-II-81. Oral administration of 100 mg/kg of either KRM-II-81 or D5-KRM-II-81 was significantly less disruptive of sensorimotor function in mice than diazepam (5 mg/kg, p.o.). The present report documents that D5-KRM-II-81 represents another in this series of imidazodiazepines with anticonvulsant activity at doses that do not impair sensorimotor function.
Abstract 2644: In vivo and in vitro stem cell models suggest a role for LGR5 in regulating intestinal epithelial lineage specification. (2013)

Abstract The stem cell marker Leucine Rich Repeat Containing G-protein Coupled Receptor 5 (LGR5) is frequently upregulated in human colon cancer. Numerous observations implicate LGR5 in stem cell maintenance during intestinal development, tissue homeostasis and cancer, however the precise role of LGR5 in these processes is still unclear. To explore the role of LGR5, we generated mouse embryonic stem cells (ESCs) in which one or both alleles of Lgr5 were deleted and replaced with either β-galactosidase or green fluorescent protein (gfp) reporter genes, or the human LGR5 gene. These cell lines were used in three complimentary systems to differentiate and/or isolate cell lineages. The first system was an in vivo model in which subcutaneous xenografts of murine ESCs grew and formed tumors (teratomas) containing cellular structures from all three germ cell layers. Immunostaining showed that a subset of E-cadherin-positive epithelial cells also expressed Lgr5 reporter genes. Teratomas derived from Lgr5 null ESCs showed an increase in E-cadherin-positive epithelial structures, and gene expression profiling of Lgr5 null teratomas showed an upregulation of epithelial genes including Cdh1, Epcam, Cldn7, Krt5, and Krt14 compared with control teratomas. In contrast, ESCs constitutively overexpressing a secreted form of LGR5 ectodomain formed teratomas with fewer epithelial structures and reduced expression of epithelial genes compared to control teratomas. The second system used in vitro differentiation of ESCs towards an intestinal epithelial lineage, followed by 3D culturing, to derive intestinal organoids. Lgr5+/+ (WT), Lgr5lacZ/+ (Het), or Lgr5lacZ/gfp (Null) ESCs are being examined for their ability to adopt an intestinal fate and form organoids in vitro. A third system used ex vivo culture of murine intestinal crypts isolated from humanized LGR5 heterozygous mice to form intestinal organoids. In summary, the morphological and gene expression changes observed in teratomas implicate a role of LGR5 in regulating epithelial tissue homeostasis. The ability to grow and manipulate organoid cultures ex vivo/in vitro will allow us to use various soluble reagents and detailed microscopy to further assess the role of the Lgr5 pathway in intestinal cell lineage specification as well as tumorigenesis. Citation Format: Courtney M. Williams, Jessica L. Harper, Hui Huang, Pat Boland, Qing Zhang, George D. Yancopoulos, Zhe Li, O. Gavin Thurston. In vivo and in vitro stem cell models suggest a role for LGR5 in regulating intestinal epithelial lineage specification. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2644. doi:10.1158/1538-7445.AM2013-2644
ChemInform Abstract: A Convergent Approach to the Total Synthesis of Telmisartan via a Suzuki Cross‐Coupling Reaction Between Two Functionalized Benzimidazoles. (2015)

Abstract A direct and efficient total synthesis is developed for telmisartan (I), a widely prescribed treatment for hypertension.
Application of ELECTRE to Network Selection in A Hetereogeneous Wireless Network Environment (2007)

Inter-working of existing packet switched wireless access technologies can help make services ubiquitously available. However this means that the services will have to be delivered over a heterogeneous mix of access technologies. There are several technical challenges that have to be overcome in such an environment, with selection of an optimal service delivery network being one of the most important issues. Choosing a nonoptimal network can result in problems such as the use of expensive access types or poor service experience. Multi attribute decision making (MADM) algorithms have been considered in the past to rank the candidate networks in a preference order. While many types of MADM algorithms exist, the decision maker may choose to use a particular type of algorithm to solve a decision problem based on an assessment of the suitability of the algorithm to the problem space. This paper adapts ELECTRE, a type of MADM algorithm that performs pair-wise comparisons amongst the alternatives, to solve the problem of network selection. The algorithm has been modified so that it is able to provide complete ranking of networks even in scenarios where the utility of some attributes is nonmonotonic. The algorithm has been evaluated by applying it to a network selection scenario in a heterogeneous wireless network environment.
Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (2017)

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine 1 as a potent I<sub>Kur</sub> current blocker with selectivity versus hERG, Na and Ca channels, and an acceptable preclinical PK profile. Upon further characterization in vivo, compound 1 demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2' position for a series of close analogues by employing hydrogen bond donors. As a result, 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (25) was identified as the lead compound in this series. Compound 25 showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clinical candidate. Further optimization of 25 to mitigate pH-dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile.
BPM for the masses: empowering participants of Cognitive Business\n Processes (2019)

Authoring, developing, monitoring, and analyzing business processes has\nrequires both domain and IT expertise since Business Process Management tools\nand practices have focused on enterprise applications and not end users. There\nare trends, however, that can greatly lower the bar for users to author and\nanalyze their own processes. One emerging trend is the attention on blockchains\nas a shared ledger for parties collaborating on a process. Transaction logs\nrecorded in a standard schema and stored in the open significantly reduces the\neffort to monitor and apply advanced process analytics. A second trend is the\nrapid maturity of machine learning algorithms, in particular deep learning\nmodels, and their increasing use in enterprise applications. These cognitive\ntechnologies can be used to generate views and processes customized for an end\nuser so they can modify them and incorporate best practices learned from other\nusers' processes.\n Keywords: BPM, cognitive computing, blockchain, privacy, machine learning\n
Diarrea vírica bovina: etiología, formas clínicas, distribución del virus y patogenia (2007)

El virus de la diarrea vírica bovina (vDVB) es un agente de distribución mundial y responsable de cuantiosas pérdidas económica a la cabaña bovina, estando clasificado dentro de la familia Flaviviridae junto a otros pestivirus como el virus de la peste porcina clásica, el virus de la enfermedad de la frontera de la oveja y el virus de la hepatitis C. Este virus se caracteriza por causar una amplia variedad de formas clínicas que van desde forma subagudas, que pasan desapercibidas, a formas caracterizadas por desarrollar una intensa leucopenia, trombocitopenia y hemorragias. Acorde con sus diferencias antigénicas y genéticas, los aislados del virus se pueden clasificar en 2 genotipos o especies: vDVB tipo 1 y vDVB tipo 2. El primero causa enfermedad leve pero en vacas preñadas, las infecciones fetales pueden inducir abortos y otras patologías reproductivas. El vDVB tipo 2 está asociado principalmente a la enfermedad respiratoria severa y a un cuadro hemorrágico agudo, caracterizado por trombocitopenia, diarrea hemorrágica, epistaxis, petequias, equimosis en mucosas, anemia, sangrado en zonas de inyección, pirexia, leucopenia y muerte.Independientemente del genotipo al que pertenezca, el vDVB puede ser clasificado en 2 biotipos acorde con su efecto sobre cultivos celulares: citopático (CP) y no citopático (NCP), siendo estos últimos los más comunes en la naturaleza. La infección del feto con cepas NCP entre los días 40 y 120 de la gestación, puede dar lugar al nacimiento de animales persistentemente infectados (PI). En estos animales el virus se distribuye ampliamente a través de todos los órganos, siendo el daño limitado, lo que permite que la gestación continúe. Estos animales están predispuestos a padecer infecciones secundarias, así como a desarrollar la denominada enfermedad de las mucosas cuando se infectan con cepas CP antigénicamente homólogas.
Electroplated Copper for Heterogeneous Die Integration (2015)

This paper introduces a heterogeneous die integration process using electroplated copper to mount a bare die into a silicon handling wafer while simultaneously forming vertical, through-wafer vias. Deep reactive-ion etching is used to form openings in the handling wafer allowing the die to be flush-mounted for minimal device thickness. The backsides of the support wafer and die are coated by copper sputtering and electroplating, which physically secures the die in place. Electrical isolation is achieved through passivation of the silicon handle wafer sidewalls before copper electroplating. Wet thermal oxide growth was chosen over plasma-enhanced chemical vapor deposition as the sidewall passivation technique, as wet thermal oxide was found to yield superior coverage and uniformity. Topside interconnects were realized using a previously established thick-film copper metallization process. A 3 × 3 die array was successfully produced and tested for die-to-die connectivity. Thermal modeling of the fabricated devices showed that power densities up to 1 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> could be accommodated while keeping the maximum temperature below 85°C.
Effect of ultraviolet radiation exposure on room-temperature hydrogen sensitivity of nanocrystalline doped tin oxide sensor incorporated into microelectromechanical systems device (2005)

The effect of ultraviolet (UV) radiation exposure on the room-temperature hydrogen (H2) sensitivity of nanocrystalline indium oxide (In2O3)-doped tin oxide (SnO2) thin-film gas sensor is investigated in this article. The present sensor is incorporated into microelectromechanical systems device using sol-gel dip-coating technique. The present sensor exhibits a very high sensitivity, as high as 65 000–110 000, at room temperature, for 900ppm of H2 under the dynamic test condition without UV exposure. The H2 sensitivity is, however, observed to reduce to 200 under UV radiation, which is contrary to the literature data, where an enhanced room-temperature gas sensitivity has been reported under UV radiation. The observed phenomenon is attributed to the reduced surface coverage by the chemisorbed oxygen ions under UV radiation, which is in consonance with the prediction of the constitutive equation, proposed recently by the authors, for the gas sensitivity of nanocrystalline semiconductor oxide thin-film sensors.