gebhart/patrepeval huggingface dataset:
Virtualized cognitive network architecture for 5G cellular networks (2015)

Cellular networks have preserved an application agnostic and base station (BS) centric architecture1 for decades. Network functionalities (e.g. user association) are decided and performed regardless of the underlying application (e.g. automation, tactile Internet, online gaming, multimedia). Such an ossified architecture imposes several hurdles against achieving the ambitious metrics of next generation cellular systems. This article first highlights the features and drawbacks of such architectural ossification. Then the article proposes a virtualized and cognitive network architecture, wherein network functionalities are implemented via software instances in the cloud, and the underlying architecture can adapt to the application of interest as well as to changes in channels and traffic conditions. The adaptation is done in terms of the network topology by manipulating connectivities and steering traffic via different paths, so as to attain the applications' requirements and network design objectives. The article presents cognitive strategies to implement some of the classical network functionalities, along with their related implementation challenges. The article further presents a case study illustrating the performance improvement of the proposed architecture as compared to conventional cellular networks, both in terms of outage probability and handover rate.
The Metal-Conjugated Peptide Nucleic Acid Challenge (2005)

This Account describes the advances in the chemistry of metal-conjugated peptide nucleic acids (PNAs) obtained in our laboratories over the last three years. Our interest in bioorganometallic chemistry began several years ago and led to new PNA research, including the design, synthesis and study of the properties of metal-conjugated PNAs with the aim of providing new molecules with suitable spectroscopic or electrochemical markers that may be ­useful in biomedical diagnostics. We describe three classes of ­metal-conjugated PNA monomers: Fischer-type carbene complexes (FTC), arene chromium tricarbonyl complexes (ACT) and ferro­cene (Fc), all of which are inserted on the α-carbon of the glycine unit in order to provide chiral substrates as well as the chemical and spectroscopic properties of the adducts. In addition, we have obtained a lysine-containing PNA 10-mer conjugated to a FTCC, in which the presence of the organometallic unit seems to stabilise the duplex with a complementary DNA strand. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies of mono- and tris-Fc labelled tyrosine PNA monomers have shown constantly reversible signals with high currents; the almost tripled current intensity of the tris-Fc monomer allows a detection limit of 10-8.
Transduction, Tropism, and Biodistribution of AAV Vectors in the Lacrimal Gland (2011)

LG gene delivery by AAV vectors appears to be both safe and well tolerated. The choice of vector influences both the overall transduction activity, as well as the spread of vector to other organs. This work supports the use of AAV-mediated gene therapy for dry eye.
An AC active filter for use at capacitor commutated HVDC converters (2001)

This paper discusses the application of an AC side active filter in HVDC schemes involving capacitor commutated converters. A suitable topology and control algorithm is selected to achieve the necessary objective of filtering the lower order characteristic harmonics. The dependence of the filter's rating on parameters such as the extent of de-tuning of its passive elements is investigated. The performance of this filter in a capacitor commutated converter application is evaluated using an electromagnetic transient simulation program.
Radiographic Variables That May Predict Clinical Outcomes in Cervical Disk Replacement Surgery (2014)

Several radiographic variables are predictive of clinical outcomes, including decreased preoperative disk space height and excessive postoperative segmental lordosis.
Redox Switching of Adenosine-5′-phosphosulfate Kinase with Photoactivatable Atomic Oxygen Precursors (2012)

Adenosine-5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine-5'-phospho-sulfate (APS) to 3'-phospho-APS (PAPS). In plants, this enzymatic activity is biochemically regulated through an intersubunit disulfide bond between Cys86 and Cys119 in the N-terminal loop of APSK. To examine if O((3)P) generated by the photodeoxygenation of 2,8-dihydroxymethyldibenzothiophene S-oxide could specifically oxidize APSK at its regulatory site, APSK was irradiated in the presence of 2,8-dihydroxymethyldibenzothiophene S-oxide. Near-quantitative alteration of APSK from the enzymatically active monomeric form to the inhibited dimeric form was achieved. The photoinduced increase of dimeric APSK was strongly implicated to arise from the formation of the Cys86-Cys119 disulfide bond.
On the bias of BFS (2010)

Breadth First Search (BFS) and other graph traversal techniques are widely used for measuring large unknown graphs, such as online social networks. It has been empirically observed that an incomplete BFS is biased toward high degree nodes. In contrast to more studied sampling techniques, such as random walks, the precise bias of BFS has not been characterized to date. In this paper, we quantify the degree bias of BFS sampling. In particular, we calculate the node degree distribution expected to be observed by BFS as a function of the fraction of covered nodes, in a random graph $RG(p_k)$ with a given degree distribution $p_k$. Furthermore, we also show that, for $RG(p_k)$, all commonly used graph traversal techniques (BFS, DFS, Forest Fire, and Snowball Sampling) lead to the same bias, and we show how to correct for this bias. To give a broader perspective, we compare this class of exploration techniques to random walks that are well-studied and easier to analyze. Next, we study by simulation the effect of graph properties not captured directly by our model. We find that the bias gets amplified in graphs with strong positive assortativity. Finally, we demonstrate the above results by sampling the Facebook social network, and we provide some practical guidelines for graph sampling in practice.
The Morpho-Productive Characterization of Tzurcana Sheep Bred in the County of Cluj (2012)

Concerning the sheep stocks in Europe, Romania occupies the third place. Turcana breed occupies the major share in Romanian stocks, being characterized by remarkable resistance, accommodation capacity, and special biodiversity not identified in other sheep breeds reared in our country. The present study was developed in a representative area for Romanian sheep rearing, the County of Cluj having important sheep stocks of 365,443 heads, of which, about 97 % is represented by Tzurcana breed. In order to develop this study, we structured the county area in five areas of sheep rearing, and for each area the following recordings were performed: body weight in adult animals, young animals and lambs, wool production, and dairy production. The body weight of the studied adult sheep had values between 55.40 kg in ewes, and 76.50 kg in rams, the recorded values being smaller compared to other populations reared in Transylvanian areal.
Choose simplicity for a better digital substation design (2017)

Digital substation process bus-based solutions provide multiple benefits that can be used to improve personnel safety around high-voltage equipment, reduce electromagnetic interference challenges, and decrease substation construction costs. To realize these benefits, special attention must be given to the selection of the fiber-optic network architecture used for a process bus implementation. Network architecture directly affects the amount of engineering required to design, commission, and maintain a digital substation. This paper outlines the benefits of using digital communications between primary substation equipment and the protective relays installed in the control house. The authors discuss different communications network architectures and their associated protocols and then introduce a point-to-point, EtherCAT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> -based digital substation technology. Simple and secure, this new solution is easy to implement, eliminates the need for external time synchronization, requires no network engineering, and is easily scalable to support traveling-wave protection and the megahertz sampling requirements of future digital substations.
ChemInform Abstract: ARENE‐METAL COMPLEXES IN ORGANIC SYNTHESIS: ADDITION TO STYRENE‐TYPE LIGANDS (1981)

Abstract Die Addition von Nucleophilen an die Styrol‐tricarbonyl‐Cr‐Komplexe (I) führt zu koordinierten Benzylanionen, die mit Elektrophilen abgefangen als Komplexe (II) isolierbar sind.
A discrete conglomerate of a distorted Mo(v)-porphyrin with a directly coordinated keggin-type polyoxometalate (2007)

The reaction of a saddle-distorted Mo(v)-dodecaphenylporphyrin complex and a Keggin-type polyoxometalate gives a discrete and nanosized molecule, [{Mo(DPP)(O)}(2)(H(2)SiW(12)O(40))], which involves direct coordination between the Mo(v) centers and terminal oxo groups of the polyoxometalate and exhibits excellent stability in solution to show reversible multi-redox processes.
The mass spectrometric fragmentation of some diastereoisomeric 4‐methyl‐1,3,2‐dioxaphosphorinanes (1978)

Abstract The mass spectra of nine diastereoisomeric pairs of 4‐methyl‐2‐X‐2‐Y‐1,3,2‐dioxaphosphorinanes have been examined. The differences between the intensities of particular ions in the mass spectra of geometrical isomers are reported and rationalized in terms of the conformations adopted by compounds.
On-Chip Single Crystal Diamond Resonators (2011)

We present a fabrication method for diamond based resonators. Optical characterization of a diamond ring resonator on quartz substrate reveals cavity modes both in the telecom and the visible wavelength regime having with Q-factors ~8000.
A modular Gigabit Ethernet backbone for NEPTUNE and other ocean observatories (2003)

Ethernet is the most popular technology used for local area networks (LANs). Recently, Gigabit Ethernet (GbE) technology has successfully competed with SONET and other legacy alternatives such as ATM and frame relay for metropolitan area network (WAN) implementations. This paper describes a modular ocean observatory node design resulting from design activities of the NEPTUNE observatory data communications team. Internal node modules based on Gigabit Ethernet, point-to-point wave division multiplexing (WDM) and TCP/IP (Internet) protocol technologies are employed to define communications building blocks used in the design of the NEPTUNE regional scale ocean observatory communications system and are also applicable to coastal, buoyed and autonomous observatory nodes.
Antigen Presenting Cells (1985)

Three major issues were discussed in the workshop: (1) the role of antigen processing in T-cell activation and situations in which it may not be necessary for T-cell stimulation, (2) the differences in antigen presenting function of macrophages and dendritic cells and the ability of dendritic cells to process antigen, and (3) the role of the type of antigen presenting cell in eliciting preferentially different functional types of T cells such as helpers and suppressors, and the role of presenting cells in tolerance.
P01.10: Volume perfusion index: mathematical modelling of aortic isthmus flow by four dimensional power Doppler: results from an experimental sheep model (2012)

Non-invasive and accurate measurement of fetal flow remains an elusive matter. Precision of current tools is very limited and relies mainly in operator skills. The aim of this study was to test a tool for indirect flow measurement, by using power Doppler signal and four-dimensional ultrasound (4DPD) and image data simulation and adjustment tools based on mathematical modelling of particles' vectorial velocities. Six near term pregnant sheep were surgically instrumented to access fetal aorta by transventricular catheterization. Actual flow through aortic isthmus was measured directly by a PICCO® monitor, as well as by pulsed Doppler. Several sets of 4DPD volumes were taken during the procedure. Measurements were stored in an electronic datasheet. A mathematical algorithm for signal normalization was developed for the project by using Mathematica®. A differencial equation matrix was generated and obtained data was evaluated through an error adjustment process. Mean velocity at every time was calculated and compared to actual data. The obtained values were plotted against the calculated values. Repeatability was evaluated by using a Bland Altmann test. A total of 30 sets of measurements were collected. A mean of six measurements by cardiac cycle were digitally obtained from the velocity curve. An n by m matrix of data was designed for every set. A mathematically generated flow curve was plotted with the data built through a multi-layer algorithm. Bland Altmann test showed an inter observer variability (95% CI) of 22.3% (11.5–34.3). The r-value for calculated flow was 0.78 (0.73–0.91) (P < 0.05). 4DPD with mathematical modeling overcomes the limitations of two and three-dimensional moving particles measurement and might be an accurate tool for fetal flow measurement.
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies (2019)

MCL-1 is one of the most frequently amplified genes in cancer, facilitating tumor initiation and maintenance and enabling resistance to anti-tumorigenic agents including the BCL-2 selective inhibitor venetoclax. The expression of MCL-1 is maintained via P-TEFb-mediated transcription, where the kinase CDK9 is a critical component. Consequently, we developed a series of potent small-molecule inhibitors of CDK9, exemplified by the orally active A-1592668, with CDK selectivity profiles that are distinct from related molecules that have been extensively studied clinically. Short-term treatment with A-1592668 rapidly downregulates RNA pol-II (Ser 2) phosphorylation resulting in the loss of MCL-1 protein and apoptosis in MCL-1-dependent hematologic tumor cell lines. This cell death could be attenuated by either inhibiting caspases or overexpressing BCL-2 protein. Synergistic cell killing was also observed between A-1592668 or the related analog A-1467729, and venetoclax in a number of hematologic cell lines and primary NHL patient samples. Importantly, the CDK9 inhibitor plus venetoclax combination was well tolerated in vivo and demonstrated efficacy superior to either agent alone in mouse models of lymphoma and AML. These data indicate that CDK9 inhibitors could be highly efficacious in tumors that depend on MCL-1 for survival or when used in combination with venetoclax in malignancies dependent on MCL-1 and BCL-2.
A frequency selective surface with integrated limiter for receiver protection (2012)

The design and simulation of a frequency selective surface (FSS) with integrated limiter for receiver-protection are presented. The FSS operates as normal until a certain power threshold is reached, at which point the temperature increase triggers a dramatic resistance change across the element, and the insertion loss changes from 0.2 dB to 20 dB. The limiting action is completely passive and automatically reversible. By placing the limiter outside of the system, no portion of the front-end risks damage from high-power signals, a level of protection not offered in conventional limiters. Finally, the design is compatible with standard lithography processes, requires no diodes, ferrites, or additional components, and can potentially be integrated on flexible substrates.
Preparation, Infrared and Raman Spectra, and Stereochemistries of Pentacoordinate Trimethylphosphine Complexes, MX4•P(CH3)3 and MX4•P(CD3)3 where M = Ge or Sn and X = Cl or Br (1973)

The 1:1 adducts MX 4• PMe 3 (M = Ge or Sn; X = Cl or Br) are prepared by recrystallization of the respective 1:2 complexes from excess MX 4 acceptor. Solid state infrared and Raman Spectra and X-ray powder photographs suggest that these adducts are all trigonal bipyramidal with the ligand in an axial position. Normal coordinate calculations in C 3v symmetry (axial ligand) and C s symmetry (equatorial ligand) support this assignment. The rather high ν(MP) frequencies indicate unusually strong metal–phosphorus donor bonds in these compounds.
Combined graft-elongation maps from in vivo kinematics data for knee laxity assessment during navigated ACL reconstruction (2010)

(poster)
Functional Characterization of the Rice UDP-glucose 4-epimerase 1, OsUGE1: A Potential Role in Cell Wall Carbohydrate Partitioning during Limiting Nitrogen Conditions (2014)

Plants grown under inadequate mineralized nitrogen (N) levels undergo N and carbon (C) metabolic re-programming which leads to significant changes in both soluble and insoluble carbohydrate profiles. However, relatively little information is available on the genetic factors controlling carbohydrate partitioning during adaptation to N-limitation conditions in plants. A gene encoding a uridine-diphospho-(UDP)-glucose 4-epimerase (OsUGE-1) from rice (Oryza sativa) was found to be N-responsive. We developed transgenic rice plants to constitutively over-express the OsUGE-1 gene (OsUGE1-OX1-2). The transgenic rice lines were similar in size to wild-type plants at the vegetative stage and at maturity regardless of the N-level tested. However, OsUGE1-OX lines maintained 18-24% more sucrose and 12-22% less cellulose in shoots compared to wild-type when subjected to sub-optimal N-levels. Interestingly, OsUGE1-OX lines maintained proportionally more galactose and glucose in the hemicellulosic polysaccharide profile of plants compared to wild-type plants when grown under low N. The altered cell wall C-partitioning during N-limitation in the OsUGE1-OX lines appears to be mediated by OsUGE1 via the repression of the cellulose synthesis associated genes, OsSus1, OsCesA4, 7, and 9. This relationship may implicate a novel control point for the deposition of UDP-glucose to the complex polysaccharide profiles of rice cell walls. However, a direct relationship between OsUGE1 and cell wall C-partitioning during N-limitation requires further investigation.
Long-Term Safety of Adalimumab in Clinical Trials in Adult Patients With Crohnʼs Disease or Ulcerative Colitis (2015)

Introduction: Adalimumab (ADA) is a fully human anti-tumor necrosis factor (TNF) monoclonal antibody used for the treatment of moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) in patients who have inadequately responded to conventional therapies. Safety from ongoing ADA trials continues to be collected, allowing assessment of long-term safety as the number of patients and the amount of exposure to ADA increase. The aim is to provide an update on the long-term safety profile of ADA in CD and UC patients. Methods: Safety data were evaluated for adult patients with CD or UC treated with ADA in randomized, placebo-controlled, phase 3 and 3b trials as well as their open-label extension studies. Treatmentemergent adverse events (AEs) were coded using the Medical Dictionary for Regulatory Activities, version 17.1(2014), and collected from the first dose to up to 70 days after the last dose or through the cutoff date of 31 Dec 2014. AE rates were assessed as events (E) per 100 patient-years (PYs) of exposure to ADA. Results: As of 31 Dec 2014, the ADA clinical safety database contained data for 3689 CD patients and 1789 UC patients, representing 4178.7 and 3371.9 PYs of ADA exposure, respectively. Overall, AE, SAE, and malignancy rates per PYs exposure were similar between the prior and the most recent data cutoffs for each disease state (Table). The type of infections in the Opportunistic infections (excluding TB) category changed in 2014 resulting in an apparent decreased rate (Table). Conclusion: ADA continues to be well tolerated in patients with moderately to severely active CD and UC. No new safety signals were identified with prolonged ADA use in these patient groups.Table 1: Safety Profile of Adalimumab in Adult CD and UC Patients
Optical passenger sensor by reflective light detection for automatic escalator (2003)

We have developed a new optical passenger sensor for automatic escalators that detects the presence and approximate position of a passenger by using reflective light detection. This sensor consists of a pair of modules that are attached to the end of the skirt guards and makes conventional posts unnecessary. The speed of the escalator with the sensor is controlled at three levels depending on the position of a passenger.
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis (2020)

The global incidence of <i>Mycobacterium abscessus</i> (Mabc), a rapidly growing nontuberculous mycobacterial strain that causes treatment-refractory pulmonary diseases, is increasing. Despite this, the host factors that allow for protection against infection are largely unknown. In this study, we found that sirtuin 3 (SIRT3), a mitochondrial protein deacetylase, plays a critical role in host defense against Mabc infection. Mabc decreased SIRT3 and upregulated mitochondrial oxidative stress in macrophages. SIRT3 deficiency led to increased bacterial loads, histopathological, and mitochondrial damage, and pathological inflammation during Mabc infection. Administration of scavengers of mitochondrial reactive oxygen species significantly decreased the in vivo Mabc burden and excessive inflammation, and induced SIRT3 expression in infected lungs. Notably, SIRT3 agonist (resveratrol) significantly decreased Mabc growth and attenuated inflammation in mice and zebrafishes, indicating the key role for SIRT3 in metazoan host defense. Collectively, these data strongly suggest that SIRT3 is a host-directed therapeutic target against Mabc infection by controlling mitochondrial homeostasis.
Pyrolysis of Alucone Molecular Layer Deposition Films Studied Using In Situ Transmission Fourier Transform Infrared Spectroscopy (2015)

The pyrolysis of alucone molecular layer deposition (MLD) films was studied in vacuum using in situ transmission Fourier transform infrared spectroscopy. The initial alucone MLD films were grown using trimethylaluminum (TMA) and either ethylene glycol (EG) (HO–(CH2)2–OH) or hydroquinone (HQ) (HO–C6H4–OH) at 150 °C. The alucone MLD films were then pyrolyzed in vacuum at temperatures ranging from 400 to 750 °C. The absorbance features for the C–H, C–C, and C–O stretching vibrations were observed to be lost at pyrolysis temperatures from 350 to 500 °C. For the alucone films grown using TMA and EG, the loss of these absorbance features was coupled to an increase in carboxylate (R-COO–) absorbance features. The carboxylate absorbance features reached their peak at a pyrolysis temperature of 450 °C and then decreased slowly with higher pyrolysis temperatures. The carboxylate absorbance features are consistent with an Al2O3/carbon composite material with Al3+/COO– species at the interface. In addition, the presence of carbon in the Al2O3/carbon composite led to an increase in the background infrared absorbance for the pyrolyzed alucone films grown using HQ containing six carbons. This background infrared absorbance is linked to electrical conductance in a network of carbon domains in the pyrolyzed alucone films, as described by Drude–Zener theory. In contrast, the alucone films grown using EG containing two carbons did not display an increase in the background infrared absorbance. This absence of background infrared absorbance is consistent with less carbon in the Al2O3/carbon composite grown using EG. The pyrolysis of the alucone films on ZrO2 particles led to very conformal Al2O3/carbon composite films, as observed by transmission electron microscopy images.