gebhart/patrepeval huggingface dataset:
Supplementary Table 1 from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males (2023)

&lt;p&gt;PDF file - 61K&lt;/p&gt;
Correction: Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA (2013)

[This corrects the article DOI: 10.1371/journal.pone.0044008.].
On the performance of a dual round-robin switch (2002)

The dual round-robin matching (DRRM) switch has a scalable, low complexity architecture which allows for an aggregate bandwidth exceeding 1 Tb/s using current CMOS technology. In this paper we prove that the DRRM switch can achieve 100% throughput under i.i.d. and uniform traffic. The DRRM is the first practical matching scheme for which this property has been proved. The performance of the DRRM switch is then studied and compared with the iSLIP switch. The delay performance under uniform traffic and the hot-spot throughput of DRRM is better than that of iSLIP, while the throughput of iSLIP under some nonuniform traffic scenarios is slightly higher than that of DRRM. Since throughput drops below 100%, under nonuniform traffic, we also examine some variations of the DRRM matching scheme for nonuniform traffic.
Total Synthesis of Rutamycin B, a Macrolide Antibiotic from Streptomyces aureofaciens (2001)

Rutamycin B (2) was synthesized from three principal subunits, spiroketal 75, keto aldehyde 83, and aldehyde 108. First, triol 62 was assembled by Julia coupling of sulfone 56 with aldehyde 58 followed by an acid-catalyzed spiroketalization. The three hydroxyl functions of 62 were successfully differentiated, leading to phosphonate 75. The latter was condensed in a Wadsworth−Emmons reaction with 83, prepared in six steps from (R)-aldehyde 76, to give 92. Coupling of the titanium enolate of 92 with 108 afforded Felkin product 109 with high stereoselectivity in a process that is critically dependent on the presence of the p-methoxybenzyl ether in the aldehyde. Transformation of 109 via aldehyde 116 to vinylboronate 122 was followed by macrocyclization under Suzuki conditions to yield 123. Exhaustive desilylation of the latter yielded rutamycin B.
Fiber Morphology Responsible for Restricted Solubility of Softwood Kraft Pulp in LiCl/DMAc (2005)

Solid-state NMR spectroscopy and FTIR microspectroscopy were used to investigate the contribution of fiber ultrastructure to the limited solubility of softwood kraft pulp in LiCl/DMAc. The insoluble residue was enriched with glucomannan, and the NMR studies suggest that cellulose fibrils are covered with linear glucomannan, which together may form an insoluble complex. Damage to the fiber ultrastructure by mechanical treatment resulted in lower crystallinity and improved solubility. The interaction between cellulose and glucomannan was probably also destroyed in damaged fibers, improving the accessibility by the solvent. The insoluble material was found to contain highly swollen fibers with very low crystallinity, but also some intact fibers with nearly original pulp crystallinity.
Céramiques semiconducteurs (1997)

Les résistances non linéaires appartiennent à la famille des composants électroniques passifs et sont utilisées, de par leur propriété unique, dans de nombreux domaines de l’électronique. Elles sont caractérisées par leur grande sensibilité à la température, inconvénient majeur pour les composants é
Quality of theHaemophilus influenzaeType b (Hib) Antibody Response Induced by Diphtheria-Tetanus-Acellular Pertussis/Hib Combination Vaccines (2007)

It has been repeatedly observed that mixing Haemophilus influenzae type b (Hib) conjugate vaccines with acellular pertussis-containing vaccines (diphtheria-tetanus-acellular pertussis [DTPa]) resulted in a reduced magnitude of the anti-polyriboseribitolphosphate antibody response compared to that obtained when Hib vaccines were administered separately and not mixed. Nevertheless, the quality and functionality of the immune responses have been shown to be the same. With the purpose of investigating the quality of the anti-Hib immune responses that are elicited under different vaccination regimens, we report here four primary and booster-based pediatric clinical trials in which Hib vaccine was either mixed with DTPa or diphtheria-tetanus-whole-cell pertussis (DTPw)-based vaccines or was coadministered. Our results show that avidity maturation of the antibodies was lower when primary vaccination involved DTPa mixed with Hib compared to when DTPa and Hib were coadministered. No such difference was observed between mixed and separately administered Hib when associated with DTPa-hepatitis B virus-inactivated poliovirus or DTPw-based vaccines. All different combinations and regimens elicited the same opsonophagocytic and bactericidal activity as well as the same ability to protect in a passive infant rat protection assay. The functional activity of mixed DTPa-based and Hib vaccines was similar to that of mixed DTPw-based/Hib combinations. In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children.
Are Corals Colorful? (2005)

Using in situ spectrometry data and visual system modeling, we investigate whether the colors conferred to the reef-building corals by GFP-like proteins would look colorful not only to humans, but also to fish occupying different ecological niches on the reef. Some GFP-like proteins, most notably fluorescent greens and nonfluorescent chromoproteins, indeed generate intense color signals. An unexpected finding was that fluorescent proteins might also make corals appear less colorful to fish, counterbalancing the effect of absorption by the photosynthetic pigments of the endosymbiotic algae, which might be a form of protection against herbivores. We conclude that GFP-determined coloration of corals may be an important factor in visual ecology of the reef fishes.
Serum Bactericidal Activity and Induction of Chemiluminescence of Polymorphonuclear Leukocytes: Complement Activation Pathway Requirements in Defense against <i>Neisseria meningitidi</i><i>s</i> (1993)

Serum bactericidal activity and chemiluminescence (CL) responses of polymorphonuclear leukocytes (PMNL) to pathogenic Neisseria meningitidis serogroups B and W-135 and to nonpathogenic serogroup 29E were examined with pooled normal human serum depleted of the complement proteins C1q, factor D, properdin and C5. Purified C1q, factor D, properdin and C5 were added alone or in combination. For investigation of serogroup W-135 meningococci, a C1q, factor D and properdin-depleted postvaccination serum with high concentrations of anticapsular antibodies was also used. Serogroup B and W-135 cultured to log phase were resistant to the bactericidal activity of pooled normal human serum but were efficiently killed through the classical pathway alone when the bacteria were cultured to stationary phase. Nonpathogenic serogroup 29E meningococci in log or stationary growth phases were efficiently killed in serum, predominantly through the classical pathway. Serogroup W-135 meningococci grown to log phase were resistant to classical pathway-mediated bactericidal activity in postvaccination serum but were killed on addition of alternative pathway proteins. Stationary phase serogroup W-135 meningococci were killed through both pathways in the postvaccination serum. In the pooled normal human serum CL responses of PMNL were consistently more pronounced with fully reconstituted C1q, factor D, properdin, C5-depleted serum than with serum reconstituted with C1q, factor D and properdin suggesting contribution of actions related to terminal components. In the absence of C1q, serogroup W-135 meningococci in postvaccination serum induced a significant but delayed alternative pathway-mediated CL response. CL responses induced by serum-opsonized meningococci, in contrast to serum bactericidal activity, were not influenced by culture conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
Color-consistent LED modules for general lighting (2009)

During the last few decades the efficacy and luminous flux of LEDs have developed fast. Also the color quality of white LEDs and LED illumination systems has improved considerably. Thanks to the performance improvements and the continuously declining cost per lumen, it is now possible to create LED lighting systems with high luminous fluxes that can be applied in downlights for general lighting and in spot lights for accent lighting. One of the important requirements on lighting systems in indoor lighting applications is the color consistency. For all systems the chromaticity, or color point, of the light should be the same, i.e. within well-defined small tolerance areas. For down lighting, LED modules with high optical efficiency have been developed based on the concept of mixing light from multiple LEDs and luminescent materials, and emitting the mixed light through a translucent window. This concept is ideal for down lighting and other general illumination applications since it enables the design of luminaires with high optical efficiencies and low glare. In addition, it enables high color uniformity and excellent color consistency between modules. The module concept enables forward compatibility by well-defined interfaces and optical properties that are decoupled from the actual performance and number of LEDs. In this paper the properties with respect to color consistency of the various concepts will be discussed. By applying a phosphor remote from the blue LEDs, we have developed mediumbrightness (100-200 kCd/m<sup>2</sup>) LED-modules with high system efficacy. This is the basis of the Philips Fortimo downlight system. Based on mixing of multiple colors, the color tunable Lexel downlight module has been developed. The systems comprising multiple LED colors have feedback loops to comply with color consistency requirements. In all systems a color consistency within 5 SDCM is achieved.
Specific Antibodies for the Detection of <b><i>Alternaria</i></b> Allergens and the Identification of Cross-Reactive Antigens in Other Fungi (2016)

Peptide-specific antibodies are useful to analyze diagnostic and therapeutic mould extracts, to study the presence of A. Alternata allergens in biological samples and to search for cross-reactive allergens in other mould species.
A 1-V Bandgap Reference in 7-nm FinFET With a Programmable Temperature Coefficient and Inaccuracy of ±0.2% From −45°C to 125°C (2019)

We present a 1-V precision voltage reference with a programmable temperature coefficient (“temp-co”). The voltage reference is based on a parasitic bipolar junction transistor (BJT) realized within the process steps available in the chosen 7-nm FinFET technology. Details of its characterization and SPICE modeling are presented to provide insight into key device-circuit optimization choices. The trimming techniques needed to cope with process spread together with two curvature compensation techniques are presented. The reference achieves a maximum inaccuracy of ±0.2% and a minimum temp-co of 6 ppm/°C from -45°C to 125°C. Furthermore, its temp-co is digitally programmable between -7 mV/100°C and +8 mV/100°C. Its line regulation is 0.1%/V, and it occupies 0.078 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization (2016)

Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin subjected to tape stripping, a surrogate for scratching, induces an IL-22 response that drives epidermal hyperplasia and keratinocyte proliferation in a mouse model of skin inflammation that shares many features of AD. DC-derived IL-23 is known to act on CD4(+) T cells to induce IL-22 production. However, the mechanisms that drive IL-23 production by skin DCs in response to cutaneous sensitization are not well understood. We demonstrate that IL-23 released by keratinocytes in response to endogenous TLR4 ligands causes skin DCs, which selectively express IL-23R, to up-regulate their endogenous IL-23 production and drive an IL-22 response in naive CD4(+) T cells that mediates epidermal thickening. We also show that IL-23 is released in human skin after scratching and polarizes human skin DCs to drive an IL-22 response, supporting the utility of IL-23 and IL-22 blockade in AD.
(αMe)Hyv: chemo-enzymatic synthesis, and preparation and preferred conformation of model depsipeptidesElectronic supplementary information (ESI) available: analytical data. See http://www.rsc.org/suppdata/p2/b1/b107691b/ (2002)

By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino acids L-Ala, L-Val, and Aib. From solution (FT-IR absorption and 1H NMR) and crystal-state (X-ray diffraction) conformational analyses we found that L-(αMe)Hyv forces depsipeptides to fold into right-handed β-turn/helical structures by analogy with the reported propensity of L-(αMe)Val, its α-amino acid counterpart.
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors (2016)

Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because known chemotypes have required a highly basic group in the S1 binding pocket for high affinity. A recently reported fragment screening effort resulted in the discovery of a neutral heterocycle, 7-chloro-3,4-dihydroisoquinolin-1(2<i>H</i>)-one, that binds in the S1 pocket of FVIIa and can be incorporated into a phenylglycine FVIIa inhibitor. Optimization of this P1 binding group led to the first series of neutral, permeable FVIIa inhibitors with low nanomolar potency.
Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species (2009)

X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the Dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.
Simulations and Measurements of the Vibroacoustic Effects of Replacing Rolling Element Bearings With Journal Bearings in a Simple Gearbox (2013)

The effects of replacing rolling element bearings with journal bearings on the noise and vibration of a simple gearbox are computationally and experimentally evaluated. A modified component mode synthesis (CMS) approach is used, where the component modes of the shafting and gearbox housing are modeled using finite element analysis (FEA). Instead of using component modes with free boundary conditions, which is typical of CMS, the shafting and gearbox are coupled using nominal impedances computed for the different bearing types, improving convergence of the solution. Methods for computing the actual bearing impedances, including the high damping coefficients in journal bearings, are summarized. The sound radiated by the gearbox is computed using a boundary element (BE) model. The modeling results are validated against measurements made at the NASA Glenn Research Center. Both simulations and measurements reveal that the journal bearings, although highly damped, do not necessarily lead to strong reductions in gearbox vibration and noise.
137. The reaction of acrylonitrile with aliphatic alcohols (1945)

J. H. MacGregor and C. Pugh, J. Chem. Soc., 1945, 535 DOI: 10.1039/JR9450000535
Cost-constrained transmit processing in wireless cellular networks with universal frequency reuse (2010)

To improve link reliability and data throughput in wireless communications, it is well known that we can exploit both the spatial and the temporal domain by precoding and scheduling, respectively. For cellular networks, however, most of these gains can only be obtained when frequency resources are carefully allocated to the different base stations as otherwise, they are compromised by the presence of intercell interference. To achieve universal frequency reuse among base stations, the idea of base station cooperation has recently attracted much attention. Unfortunately, the costs of this cooperation in terms of channel state information diminish most of the benefits. This paper proposes scheduling and precoding techniques under universal frequency reuse that address these costs to recover the gains of temporal scheduling and spatial precoding in the downlink of cellular multiple input single output (MISO) systems with multiple non-cooperative users per cell.
ChemInform Abstract: A NEW DIENE SYNTHESIS VIA ORGANOPALLADIUM CHEMISTRY (1980)

Abstract Die Addition des Dianions der Propionsäure an (E)‐2‐Phenylcrotonaldehyd bzw. des Dianions von Phenylessigsäure an (E)‐Zimtaldehyd gefolgt von in situ‐Acetylierung liefert die Ausgangsverbindungen (I) als 1:1‐ bzw. 3 : 1‐Diastereomerenmischungen.Werden diese in Gegenwart des Pd‐Komplexes (II) erhitzt, so erhält man die E,E‐Diene (IIIa) bzw. (IIIb).
A 40 Gb/s PAM4 silicon microring resonator modulator transmitter in 65nm CMOS (2016)

A silicon photonic microring resonator modulator transmitter utilizes a segmented pulsed-cascode output stage for voltage level control to achieve PAM4 modulation on a single microring device. The 65nm CMOS transmitter achieves 40Gb/s operation at 3.04mW/Gb/s when driving depletion-mode microring modulators with 4.4Vppd swing.
Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A (2014)

Periodontitis is a chronic inflammatory disease accompanied by alveolar bone resorption by osteoclasts. Porphyromonas gingivalis, an etiological agent for periodontitis, produces cysteine proteases called gingipains, which are classified based on their cleavage site specificity (i.e. arginine (Rgps) and lysine (Kgps) gingipains). We previously reported that Kgp degraded osteoprotegerin (OPG), an osteoclastogenesis inhibitory factor secreted by osteoblasts, and enhanced osteoclastogenesis induced by various Toll-like receptor (TLR) ligands (Yasuhara, R., Miyamoto, Y., Takami, M., Imamura, T., Potempa, J., Yoshimura, K., and Kamijo, R. (2009) Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin. Biochem. J. 419, 159-166). Osteoclastogenesis is induced not only by TLR ligands but also by proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-17A, in inflammatory conditions, such as periodontitis. Although Kgp augmented osteoclastogenesis induced by TNF-α and IL-1β in co-cultures of mouse osteoblasts and bone marrow cells, it suppressed that induced by IL-17A. In a comparison of proteolytic degradation of these cytokines by Kgp in a cell-free system with that of OPG, TNF-α and IL-1β were less susceptible, whereas IL-17A and OPG were equally susceptible to degradation by Kgp. These results indicate that the enhancing effect of Kgp on cytokine-induced osteoclastogenesis is dependent on the difference in degradation efficiency between each cytokine and OPG. In addition, elucidation of the N-terminal amino acid sequences of OPG fragments revealed that Kgp primarily cleaved OPG in its death domain homologous region, which might prevent dimer formation of OPG required for inhibition of receptor activator of nuclear factor κB ligand. Collectively, our results suggest that degradation of OPG by Kgp is a crucial event in the development of osteoclastogenesis and bone loss in periodontitis.
OPEN QUESTIONS (1983)

In this chapter we discuss some important open questions and conjectures concerning difference sets. Answering these questions apparently will require new and powerful techniques or clever counterexamples; perhaps the reader will try to wrestle with one or more of these questions.
Solid-state NMR study of trehalose/1,2-dipalmitoyl-sn-phosphatidylcholine interactions (1986)

31P and 2H solid-state NMR studies of dry trehalose (TRE) and 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) mixtures are reported. 31P spectra are consistent with a rigid head group above and below the calorimetric phase transition for both dry DPPC and a dry 2:1 TRE/DPPC mixture. In addition, 2H spectra of DPPC labeled at the 7-position of the sn-2 chain (2[7,7-2H2]DPPC) show exchange-narrowed line shapes with a width of 120 kHz over the temperature range 25-75 degrees C. These line shapes can be simulated with a model involving two-site jumps of the deuteron. In contrast, the 2H NMR spectrum of a dry 2:1 TRE/2[7,7-2H2]DPPC mixture above the phase transition (Tc = 46 degrees C) is narrowed by a factor of approximately 4 to a width of 29 kHz. Simulation of this spectrum requires a model involving four-site jumps of the deuteron and is indicative of highly disordered lipid acyl chains similar to those found in the L alpha-phases of hydrated lipids. Thus, TRE/DPPC mixtures above their transition temperatures exist in a new type of liquid crystalline like phase, which we term a lambda-phase. The observation of the dynamic properties of this new phase indicates the mechanism by which anhydrobiotic organisms maintain the integrity of their membranes upon dehydration.
Table S1 from Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors (2023)

&lt;p&gt;Genetic features and subtypes of the cell lines used.&lt;/p&gt;
Fine pitch micro-bump Cu/Sn solid state diffusion bonding with and without surface planarization (2012)

3D integration requires a physical stacking of die onto another die while forming a permanent electrical and mechanical connection between the input/output pins of the devices. Low temperature stacking of dies for 3D integration has been gaining interest due to the thermal sensitivity of some advanced node devices such as DRAM. This paper presents a systematic study of Cu/Sn solid state diffusion bonding. This includes the use of bump surface conditioning and surface planarization. The Cu/Sn solid state diffusion bonding together with Cu TSV is used for making die to die vertical interconnection.