gebhart/patrepeval huggingface dataset:
Acoustic Power Transfer and Communication With a Wireless Sensor Embedded Within Metal (2018)

Thick metal barriers prevent the use of conventional electromagnetic wireless power transfer due to Faraday shielding effects. Here, for the first time, we demonstrate power transfer to and communication with a compact wireless sensor transponder fully embedded within a solid piece of metal through the use of ultrasonic waves. This technique is an important innovation for applications, such as structural health monitoring of solid metal structural components, which would be weakened by the presence of holes for wiring. The embedded sensor system consists of a single piezoelectric transducer used for both power and data communication, along with an energy storage unit and associated charging circuitry, as well as a representative sensor and sensor data acquisition electronics. The entire sensor transponder was packaged within a compact volume of 11.9 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> (0.73 in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) and can be further miniaturized to millimeter-scale sizes with the use of widely available system-on-chip technologies. The measured power transfer and sensor data results were found to closely match modeling results, achieving a power transfer efficiency of 33% at 440 kHz, showcasing the feasibility and potential of this approach.
Arbitrary vectorial state conversion using liquid crystal spatial light modulators (2019)

There is significant interest in the generation of complex vector beams, where the combined polarisation and phase profile is chosen to have particular properties. These beams have often been implemented in an adaptable manner using liquid crystal spatial light modulators (SLMs). Existing methods have concentrated mainly on the generation of these vector beams from a fixed polarisation state, but there are also applications were conversion between vectorial states is necessary. We discuss the limitations of existing SLM-based modulation systems for conversion between arbitrary vectorial states. Three degrees of freedom are required in principle for transition between two arbitrary states. We show that a three-SLM system can provide conversion between two arbitrary polarisation states, but cannot necessarily provide a full 2π radian phase modulation. Hence, we propose a design using four SLMs that removes these limitations on the phase modulation.
Developments in aircraft interior acoustics—Recent progress and directions (1998)

Aircraft interior noise is a continuing problem for a wide range of aircraft types. High interior noise levels in general aviation aircraft make any communication difficult, significantly impact pilot endurance, and are considered important to the reemergence of this class of aircraft. For passengers in propeller-powered commuter aircraft, conversation is difficult at best and becomes oppressive on the passengers for long periods. It is also regarded as one reason for the replacement of propeller commuter aircraft by the emerging regional jet. In business jets, the passengers are often interested in conducting meetings during flights. This calls for low SPL and SIL for which the aircraft incurs both space and weight penalties. Large commercial aircraft pay a significant weight penalty for current interior noise levels considered acceptable. With the drive for more weight-efficient airframes, the challenge becomes even more difficult. This paper will overview current efforts to develop both design and noise control techniques. These range from improvements in the quantification of the noise sources, to considerations in the overall structural design, and to the use of both active and passive control tools. In addition, the emerging use of predictive and measurement tools will be discussed and applications to aircraft highlighted.
A GPU-based framework for simulation of medical ultrasound (2009)

Simulation of ultrasound (US) images from volumetric medical image data has been shown to be an important tool in medical image analysis. However, there is a trade off between the accuracy of the simulation and its real-time performance. In this paper, we present a framework for acceleration of ultrasound simulation on the graphics processing unit (GPU) of commodity computer hardware. Our framework can accommodate ultrasound modeling with varying degrees of complexity. To demonstrate the flexibility of our proposed method, we have implemented several models of acoustic propagation through 3D volumes. We conducted multiple experiments to evaluate the performance of our method for its application in multi-modal image registration and training. The results demonstrate the high performance of the GPU accelerated simulation outperforming CPU implementations by up to two orders of magnitude and encourage the investigation of even more realistic acoustic models.
Molecular Design of a Metal-Nitrosyl Ferroelectric with Reversible Photoisomerization (2023)

The development of photo-responsive ferroelectrics whose polarization may be remotely controlled by optical means is of fundamental importance for basic research and technological applications. Herein, we report the design and synthesis of a new metal-nitrosyl ferroelectric crystal (DMA)(PIP)[Fe(CN)<sub>5</sub>(NO)] (<b>1</b>) (DMA = dimethylammonium, PIP = piperidinium) with potential phototunable polarization via a dual-organic-cation molecular design strategy. Compared to the parent non-ferroelectric (MA)<sub>2</sub>[Fe(CN)<sub>5</sub>(NO)] (MA = methylammonium) material with a phase transition at 207 K, the introduction of larger dual organic cations both lowers the crystal symmetry affording robust ferroelectricity and increases the energy barrier of molecular motions, endowing <b>1</b> with a large polarization of up to 7.6 μC cm<sup>-2</sup> and a high Curie temperature (<i>T</i><sub>c</sub>) of 316 K. Infrared spectroscopy shows that the reversible photoisomerization of the nitrosyl ligand is accomplished by light irradiation. Specifically, the ground state with the N-bound nitrosyl ligand conformation can be reversibly switched to both the metastable state I (MSI) with isonitrosyl conformation and the metastable state II (MSII) with side-on nitrosyl conformation. Quantum chemistry calculations suggest that the photoisomerization significantly changes the dipole moment of the [Fe(CN)<sub>5</sub>(NO)]<sup>2-</sup> anion, thus leading to three ferroelectric states with different values of macroscopic polarization. Such optical accessibility and controllability of different ferroelectric states via photoinduced nitrosyl linkage isomerization open up a new and attractive route to optically controllable macroscopic polarization.
Scalable Spheroid Model of Human Hepatocytes for Hepatitis C Infection and Replication (2014)

Developing effective new drugs against hepatitis C (HCV) virus has been challenging due to the lack of appropriate small animal and in vitro models recapitulating the entire life cycle of the virus. Current in vitro models fail to recapitulate the complexity of human liver physiology. Here we present a method to study HCV infection and replication on spheroid cultures of Huh 7.5 cells and primary human hepatocytes. Spheroid cultures are constructed using a galactosylated cellulosic sponge with homogeneous macroporosity, enabling the formation and maintenance of uniformly sized spheroids. This facilitates easy handling of the tissue-engineered constructs and overcomes limitations inherent of traditional spheroid cultures. Spheroids formed in the galactosylated cellulosic sponge show enhanced hepatic functions in Huh 7.5 cells and maintain liver-specific functions of primary human hepatocytes for 2 weeks in culture. Establishment of apical and basolateral polarity along with the expression and localization of all HCV specific entry proteins allow for a 9-fold increase in viral entry in spheroid cultures over conventional monolayer cultures. Huh 7.5 cells cultured in the galactosylated cellulosic sponge also support replication of the HCV clone, JFH (Japanese fulminant hepatitis)-1 at higher levels than in monolayer cultures. The advantages of our system in maintaining liver-specific functions and allowing HCV infection together with its ease of handling make it suitable for the study of HCV biology in basic research and pharmaceutical R&D.
ChemInform Abstract: COUPLING OF ALKENES WITH FISCHER‐TYPE ALKYLIDENE COMPLEXES OF IRON (1984)

Abstract Die Reaktionen der Fe‐carben‐Komplexe (I) mit den Alkenen (II) führt unter Kupplung der unsubstituierten CH 2 ‐Gruppe des Alkens mit dem Carben‐C‐Atom zu den Umlagerungsprodukten (IIIa‐c) und /oder (IVa, c‐e).
Complex Formation of Myrosinase Isoenzymes in Oilseed Rape Seeds Are Dependent on the Presence of Myrosinase-Binding Proteins (2002)

The enzyme myrosinase (EC 3.2.3.1) degrades the secondary compounds glucosinolates upon wounding and serves as a defense to generalist pests in Capparales. Certain myrosinases are present in complexes together with other proteins such as myrosinase-binding proteins (MBP) in extracts of oilseed rape (Brassica napus) seeds. Immunhistochemical analysis of wild-type seeds showed that MBPs were present in most cells but not in the myrosin cells, indicating that the complex formation observed in extracts is initiated upon tissue disruption. To study the role of MBP in complex formation and defense, oilseed rape antisense plants lacking the seed MBPs were produced. Western blotting and immunohistochemical staining confirmed depletion of MBP in the transgenic seeds. The exclusive expression of myrosinase in idioblasts (myrosin cells) of the seed was not affected by the down-regulation of MBP. Using size-exclusion chromatography, we have shown that myrosinases with subunit molecular masses of 62 to 70 kD were present as free dimers from the antisense seed extract, whereas in the wild type, they formed complexes. In accordance with this, MBPs are necessary for myrosinase complex formation of the 62- to 70-kD myrosinases. The product formed from sinalbin hydrolysis by myrosinase was the same whether MBP was present or not. The performance of a common beetle generalist (Tenebrio molitor) fed with seeds, herbivory by flea beetles (Phyllotreta undulata) on cotyledons, or growth rate of the Brassica fungal pathogens Alternaria brassicae or Lepthosphaeria maculans in the presence of seed extracts were not affected by the down-regulation of MBP, leaving the physiological function of this protein family open.
Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS‐J): Baseline characteristics, treatment history and disease burden (2019)

Moderate to severe atopic dermatitis (AD) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long-term disease control in the Japanese population. ADDRESS-J is a non-interventional, observational registry of adult Japanese patients with moderate to severe AD. Herein, we report baseline data from the ADDRESS-J study describing disease characteristics and current treatment practices. At baseline, 300 adult AD patients with Investigator's Global Assessment (IGA) scores (range, 0-4) of 3 (moderate) or 4 (severe) whose treatments for AD were intensified, were assessed for clinical and patient-reported outcomes and current AD treatments. The registry patients' median age was 34.0 years; 60.7% were male and 71.7% had had AD for more than 20 years. At baseline, 220 study patients had an IGA score of 3 and 80 had an IGA score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0-72), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0-10); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for AD. This registry cohort represents a population of Japanese patients with moderate to severe AD and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various AD treatments.
Procyanidins from the roots of Fragaria vesca: Characterization and pharmacological approach. (1988)

Water-soluble procyanidins obtained by fermentation of a tannin exrtact of roots Fragaria vesca were analyzed by high performance liquid chromatography. Three dimers, procyanidins B1, B2 and B5, and two monomers, (+) catechin and (-) epicatechin, were identified and quantified. These procyanidins exhibit antibacterial and marked angiprotective properties.
An Experimental Study of the Hydrodynamic Characteristics of External Loop Airlift Contactors (1997)

Global hydrodynamic characteristics—gas hold-up and liquid circulating velocity—were measured in two external loop airlift contactors. Geometrical parameters, such as the height of the airlift, the design of the phase separator, the gas sparger and operating parameters, were found to have significant effects on global hydrodynamic characteristics. In particular, circulation velocity was found to be dependent on liquid volume. To predict gas hold-up in the riser, a simple model, which gives good agreement with experimental data obtained with various airlift geometries, was proposed. © 1997 SCI.
The role of peripheral T–cell deletion in transplantation tolerance (2001)

The apoptotic deletion of thymocytes that express self-reactive antigen receptors is the basis of central (thymic) self-tolerance. However, it is clear that some autoreactive T cells escape deletion in the thymus and exist as mature lymphocytes in the periphery. Therefore, peripheral mechanisms of tolerance are also crucial, and failure of these peripheral mechanisms leads to autoimmunity. Clonal deletion, clonal anergy and immunoregulation and/or suppression have been suggested as mechanisms by which 'inappropriate' T-lymphocyte responses may be controlled in the periphery. Peripheral clonal deletion, which involves the apoptotic elimination of lymphocytes, is critical for T-cell homeostasis during normal immune responses, and is recognized as an important process by which self-tolerance is maintained. Transplantation of foreign tissue into an adult host represents a special case of 'inappropriate' T-cell reactivity that is subject to the same central and peripheral tolerance mechanisms that control reactivity against self. In this case, the unusually high frequency of naive T cells able to recognize and respond against non-self-allogeneic major histocompatibility complex (MHC) antigens leads to an exceptionally large pool of pathogenic effector lymphocytes that must be controlled if graft rejection is to be avoided. A great deal of effort has been directed toward understanding the role of clonal anergy and/or active immunoregulation in the induction of peripheral transplantation tolerance but, until recently, relatively little progress had been made towards defining the potential contribution of clonal deletion. Here, we outline recent data that define a clear requirement for deletion in the induction of peripheral transplantation tolerance across MHC barriers, and discuss the potential implications of these results in the context of current treatment modalities used in the clinical transplantation setting.
Neutrophil extracellular traps blockade in combination with PD-1 inhibition in treatment of colorectal cancer metastasis. (2020)

e16002 Background: Immune checkpoint inhibitors (ICIs) are currently approved for microsatellite instability-high metastatic colorectal cancer (mCRC) however reported objective response rate to monotherapy range between 28-52%. Neutrophil Extracellular Traps (NETs), an extracellular network of DNA and proteins expelled by neutrophils into the tumor microenvironment, promote CRC metastasis by inducing potent immunosuppressive effects. We hypothesize that targeting this network may improve response rates to immune checkpoint therapy. The purpose of our study is to investigate the effect of combination DNase I treatment, a NET depleting agent, and PD-1 blockade in mCRC progression. Methods: Subcutaneous MC38 (MSI-H adenocarcinoma of the colon) tumors were established in 6-week-old mice. Treatment was initiated six days after tumor inoculation with daily intraperitoneal (i.p) injections of DNase I followed by i.p anti-PD-1 treatment administered every 3 days. Animals were divided into treatment groups: control, DNase alone, anti-PD-1 alone and combination of DNase I with anti-PD-1 (n = 6 mice/ group). Results: Tumors were successfully established after 6 days of inoculation. These tumors expressed high neutrophil infiltration and NETs. To determine the effects of combination therapy on tumor progression, we measured tumor volume and time to progression (TTP). We found that mice treated with combination DNase I and anti-PD-1 had significantly lower mean tumor volume compared to anti-PD-1 alone (1372.68mm 3 vs 2193.20 mm 3 , p-value = 0.043). TTP was higher in the combination group compared to anti-PD-1 treatment alone (median time to progression 22 vs 17 days, p-value = 0.004). Next we sought to determine the mechanism behind this effect by investigating if NETs blockade modulated the tumor microenvironment. We found that treatment with DNase I decreased exhaustion of CD8+ T-cells in the tumor compared to no treatment. Conclusions: Targeting NETs in combination with immune checkpoint inhibition may be an option to improve response rate to immune checkpoint inhibitors through decreasing exhausted CD8+ T-cells.
Modal Properties of Perturbed Few-Mode Optical Fibers (2016)

We examine the modal properties of few-mode optical fibers with respect to two common fiber perturbations, birefringence and core non-circularity, and investigate the relationship of the fiber’s true and LP modes in a quantitative way.
VQD: Visual Query Detection in Natural Scenes (2019)

We propose Visual Query Detection (VQD), a new visual grounding task. In VQD, a system is guided by natural language to localize a variable number of objects in an image. VQD is related to visual referring expression recognition, where the task is to localize only one object. We describe the first dataset for VQD and we propose baseline algorithms that demonstrate the difficulty of the task compared to referring expression recognition.
ChieF: A Change Pattern based Interpretable Failure Analyzer (2018)

Discovering the underlying dynamics leading up to an industrial asset failure is an important problem to be solved for successful development of Predictive Maintenance techniques. Existing work has largely focused on building complex ML/AI models for developing Predictive Maintenance solution patterns, but has largely avoided developing methods to explain the underlying failure dynamics. In this paper, we use an old but significantly improved change-pattern based technique to analyze IoT sensor data and failure information to generate useful and interpretable failure-centric insight. We discuss a solution pattern that we call ChieF, which when applied on multi-variate time series datasets, discover the leading failure indicators, generate associative patterns among multiple features, and output temporal dynamics of changes. Experimental analysis of ChieF on four datasets uncovers insights that may be valuable for predictive maintenance.
Temperature dependent magnetic properties of the GaAs substrate of spin-LEDs (2006)

The temperature dependence of the magnetization of a light emitting diode having a ferromagnetic contact (spin-LED) is measured from 2 to 300 K in magnetic fields from 30 to 70 kOe and it is found that it originates from the GaAs substrate. The magnetization of GaAs comprises a van Vleck-type paramagnetic contribution to the susceptibility which scales inversely with the band gap of the semiconductor. Thus, the temperature dependence of the band gap of GaAs accounts for the non-linear temperature dependent magnetic susceptibility of GaAs and thus, at large magnetic fields, for the spin-LED.
Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration (2014)

In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone morphogenetic protein-2 (BMP-2) and substance P (SP), and that this delivery promotes bone formation on titanium (Ti) implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs), was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.
Runtime and Architecture Support for Efficient Data Exchange in Multi-Accelerator Applications (2014)

Heterogeneous parallel computing applications often process large data sets that require multiple GPUs to jointly meet their needs for physical memory capacity and compute throughput. However, the lack of high-level abstractions in previous heterogeneous parallel programming models force programmers to resort to multiple code versions, complex data copy steps and synchronization schemes when exchanging data between multiple GPU devices, which results in high software development cost, poor maintainability, and even poor performance. This paper describes the HPE runtime system, and the associated architecture support, which enables a simple, efficient programming interface for exchanging data between multiple GPUs through either interconnects or cross-node network interfaces. The runtime and architecture support presented in this paper can also be used to support other types of accelerators. We show that the simplified programming interface reduces programming complexity. The research presented in this paper started in 2009. It has been implemented and tested extensively in several generations of HPE runtime systems as well as adopted into the NVIDIA GPU hardware and drivers for CUDA 4.0 and beyond since 2011. The availability of real hardware that support key HPE features gives rise to a rare opportunity for studying the effectiveness of the hardware support by running important benchmarks on real runtime and hardware. Experimental results show that in a exemplar heterogeneous system, peer DMA and double-buffering, pinned buffers, and software techniques can improve the inter-accelerator data communication bandwidth by 2×. They can also improve the execution speed by 1.6× for a 3D finite difference, 2.5× for 1D FFT, and 1.6× for merge sort, all measured on real hardware. The proposed architecture support enables the HPE runtime to transparently deploy these optimizations under simple portable user code, allowing system designers to freely employ devices of different capabilities. We further argue that simple interfaces such as HPE are needed for most applications to benefit from advanced hardware features in practice.
Development of Human-Robot Interface using Inertial Sensors for Robot Teaching (2019)

Conventional teaching methods with robots include remote teaching and direct teaching. These teaching methods have problems in terms of difficulty teaching sensibly and teacher safety. In order to solve these problems, sensuous but remote teaching is ideal for the teacher. We extracted the target position and posture information of the robot to be taught using inertial sensors and applied our system to the actual robot. As a result, we showed that it is possible to manipulate the end effector of robot arm in any direction by using this system.