gebhart/patrepeval huggingface dataset:
Direct Fabrication of Custom Orthopedic Implants Using Electron Beam Melting Technology (2005)

Metal orthopedic implants have been used for many decades with great success. Replacement joints and plates for bone fractures are usually made from titanium, cobaltchromium or stainless steel. Through recent advancements in biomodeling, custom orthopedic implants can be designed. However, fabrication of these custom implants can be prohibitively expensive with traditional processes. With the introduction of Electron Beam Melting (EBM), direct fabrication of fully dense metal components is possible. In this paper, the development of titanium for the EBM-process will be discussed, and direct fabrication of custom designed orthopedic implants made out of steel and titanium will be demonstrated.
Identifying in vivo DCE MRI markers associated with microvessel architecture and gleason grades of prostate cancer (2015)

Computer extracted features of prostate DCE MRI appear to be correlated with microvessel architecture and may be discriminative of low versus intermediate and high GS.
Computation of significance scores of unweighted Gene Set Enrichment Analyses (2007)

We present a novel dynamic programming algorithm for calculating exact significance values of unweighted Gene Set Enrichment Analyses. Our algorithm avoids typical problems of nonparametric permutation tests, as varying findings in different runs caused by the random sampling procedure. Another advantage of the presented dynamic programming algorithm is its runtime and memory efficiency. To test our algorithm, we applied it not only to simulated data sets, but additionally evaluated expression profiles of squamous cell lung cancer tissue and autologous unaffected tissue.
ChemInform Abstract: Transition Metal Catalyzed (5 + 2) Cycloadditions of Vinylcyclopropanes and Alkynes: A Homologue of the Diels‐Alder Reaction for the Synthesis of Seven‐Membered Rings. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of Compact Electrodynamic Zero-Net Mass-Flux Actuators (2009)

This work presents the systematic modeling, design and fabrication of compact electrodynamic zero-net mass-flux (ZNMF) actuators for flow control applications. The electrodynamic actuation scheme employs a small magnetic assembly and composite diaphragm with a rigid center boss and compliant outer annular region. The magnetic assembly is modeled using a 1-D magnetic circuit approach to predict the magnetic field acting on the driver coils. The composite diaphragm is modeled as a transversely isotropic, clamped plate. An overall system model is obtained by combining previously developed lumped models of the cavity/orifice structures with lumped models for the composite diaphragm and electrodynamic actuation. The complete lumped element model is then used to derive insights regarding performance characteristics and limitations. The model is validated with experimental results for three different actuator configurations. Velocities greater than 35 m/s are achieved over a frequency range 50 Hz – 200 Hz using a 30 mm diameter, 50 cm 3 total volume, 80 g actuator. I. Introduction
Flexible Soft Frequency Reuse Schemes for Heterogeneous Networks (Macrocell and Femtocell) (2011)

A mass deployment of femtocells is anticipated to affect a number of areas more adversely, especially in the cell-edge of the macrocell network. In this paper, we propose a flexible frequency-partitioning scheme for OFDMA network based on cyclic difference sets. The cyclic property of these sets allows a quick construction of orthogonal patterns for the macrocell network with an emphasis on tri-sector sites. The impact and the co-deployment of femtocells is also investigated. Unlike, with existing works in the literature, the novel scheme can adaptively control the level of coverage in the cell-edges areas and additionally enables coexistence of femtocells in the network. Simulation results confirm the effectiveness of the proposed scheme in both macrocell and femtocell networks compared to the legacy soft frequency reuse and universal frequency reuse.
Metallothionein regulates intracellular zinc signaling during CD4+ T cell activation (2016)

Differences in zinc signaling associated with MT expression appear to be a result of preferential oxidation of MT and concomitant release of Zn(2+). Although zinc is released from many proteins following oxidation, release is greater when the cell contains an intracellular pool of MT. By expressing MT in response to certain environmental conditions, CD4(+) T cells are able to more efficiently release intracellular zinc and regulate signaling pathways following stimulation. The link between MT expression and increased zinc signaling following activation represents an important immunomodulatory mechanism of MT and illuminates the complex role MT plays in shaping immune responses.
A luminescent oxygen-sensing hydrogel for open wounds (Conference Presentation) (2019)

Of the reported ~20,000 skin disease related deaths in 2013, 30% were attributed to cutaneous infections, ulcers, wounds, and burns. Wound healing is currently visually assessed by physicians and commonly requires multiple clinical visits for frequent dressing changes. These are often painful and can further compromise tissue health along with increasing infection risks. Clinical workflows for skin wounds often include oxygenation assessment to help guide the course of treatment. However, the low oxygen perfusion intrinsic to these conditions renders standard-of-care blood oxygen saturation tools inaccurate. Transcutaneous oxygen measurements can overcome this issue, albeit with further complications such as time-consuming bedside calibrations and potentially painful application/removal of electrodes. We present a ‘SMART’ bandage approach that features clinically-validated oxygen sensing molecules embedded within a hydrogel for direct open wound oxygenation measurements. The hydrogel incorporates a phosphorescent red-emitting oxygen-sensing metalloporphyrin covalently attached to a green fluorescent reference dye. As phosphorescence is quenched via collisional energy exchange with molecular oxygen, phosphorescence intensity and lifetime can be used to quantify oxygenation. The emission is bright enough to be visualized by the naked eye, and its intensity was found to increase 10x in oxygen deprived environments (0 mmHg pO2) compared to room air (160 mmHg pO2). Additionally, the hydrogel is capable of swelling up to 400% of its original size in wound exudate while maintaining skin adhesion properties. Along with minimizing the time and materials required for re-dressing, this novel wound dressing has potential for mediating drug delivery and reducing unnecessary patient discomfort.
Techniques for assessing fluids status in patients with kidney disease (2016)

Purpose of review The aim of this article is to present current information on techniques for fluid status assessment in patients with kidney disease. The methods can be broadly categorized into biomarkers, ultrasound, blood volume monitoring, and bioimpedance. Recent findings Biomarkers including atrial natriuretic peptide and B-type natriuretic peptide have been shown to provide information about relative changes in fluid status. Ultrasound is applied to measure inferior vena cava indices, pulmonary indicators, and vascular indicators of fluid overload. Relative blood volume monitoring is used to measure change in intravascular fluid during hemodialysis. While in principle appealing, measurement of absolute blood volume has seen limited use to date. Bioimpedance techniques such as vector analysis, whole body, and regional bioimpedance spectroscopy, have shown their ability to estimate fluid status. Summary The interpretation of biomarkers is complicated by the presence of cardiac disease. All ultrasound methods have some correlation with fluid status; however, operator dependency limits their routine use. Bioimpedance methods and relative blood volume monitoring are increasingly used to assess fluid status in patients with acute or chronic kidney disease. Measurement of absolute blood volume holds promise for the future.
Propene polymerization with MgCl2‐supported catalysts: effects of using a diether as external donor (1997)

Abstract 13 C NMR analysis of poly(propylene) fractions of different tacticity, obtained using a catalyst system of type MgCl 2 /TiCl 4 /diisobutyl phthalate – AlEt 3 – diether, has provided further evidence that the active species in this system are similar to those in which the ether is used as “internal” rather than “external” donor. Chain‐end analysis of relatively low molecular weight polymer fractions indicated, for polymers of similar molecular weight, similar proportions of butyl‐terminated chain‐ends, indicative of chain transfer with hydrogen following regioirregular (2,1‐) insertion. The relatively high hydrogen response of diether‐containing catalyst systems can therefore be largely ascribed to this phenomenon, irrespective of whether the diether is used as internal or external donor. At relatively low hydrogen concentrations, chain transfer to hydrogen takes place predominantly after the occasional secondary insertion, while the additional presence of vinylidene chain‐ends in certain xylene‐soluble fractions indicates that chain transfer via β‐H transfer takes place mainly after primary insertion.
Novel Sulfinyl Imine Ligands for Asymmetric Catalysis. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Interference of single photons from two separate semiconductor quantum dots (2011)

We demonstrate interference between discrete photons emitted by two different semiconductor quantum dots and quantify their degree of indistinguishability. The quantum dot emission energies are tuned into resonance by straining the samples. Upon interference on a beamsplitter, the photons are shown to be 18.1% indistinguishable, resulting in a coincidence detection rate below the classical limit. Post-selecting only those detections occurring within a short time of each other increases the measured indistinguishability to 47%. The photons are partially distinguishable due to dephasing of the exciton states, and post-selection is also affected by the detector response time.
Correction to Superior Wear-Resistance of Ti3C2Tx Multi-Layer Coatings (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAdditions and Correc...Additions and CorrectionsNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Superior Wear-Resistance of Ti3C2Tx Multi-Layer CoatingsPhilipp G. Grützmacher*Philipp G. GrützmacherMore by Philipp G. Grützmacherhttps://orcid.org/0000-0001-7609-9535, Sebastian SuarezSebastian SuarezMore by Sebastian Suarez, Aura TolosaAura TolosaMore by Aura Tolosa, Carsten GachotCarsten GachotMore by Carsten Gachot, Guichen SongGuichen SongMore by Guichen Song, Bo WangBo WangMore by Bo Wanghttps://orcid.org/0000-0003-2270-2241, Volker PresserVolker PresserMore by Volker Presser, Frank MücklichFrank MücklichMore by Frank Mücklich, Babak AnasoriBabak AnasoriMore by Babak Anasori, and Andreas Rosenkranz*Andreas RosenkranzMore by Andreas Rosenkranzhttps://orcid.org/0000-0002-9006-1127Cite this: ACS Nano 2022, 16, 2, 3433Publication Date (Web):January 24, 2022Publication History Received16 January 2022Published online24 January 2022Published inissue 22 February 2022https://pubs.acs.org/doi/10.1021/acsnano.2c00535https://doi.org/10.1021/acsnano.2c00535correctionACS PublicationsCopyright © 2022 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1247Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (484 KB) Get e-Alertsclose Get e-Alerts
Clinical pharmacology of tezosentan, a dual endothelin receptor antagonist, in patients with liver cirrhosis (2004)

Tezosentan (T) is a dual endothelin (ET) receptor antagonist, formulated for parenteral use and excreted unchanged in bile. Since ET-1 may play a role in the pathogenesis of ascites and portal hypertension, cirrhosis and its complications may form an indication for T. The objectives of this study were to explore the tolerability, pharmacokinetics, and pharmacodynamics of T in patients with moderate/severe liver cirrhosis (Child-Pugh B-C). Each patient (total n=25) received 2 consecutive 24-h infusions of 0.2 and 1.0 or 1.0 and 5.0 mg/h of T or placebo. Blood pressure was monitored and blood samples were taken for measurement of T and ET-1. T was well tolerated (mainly mild headache as adverse event) and induced small dose-dependent reductions in blood pressure. T showed dose-proportional, 2-compartment pharmacokinetics: rapid distribution and slower elimination. Its exposure was dependent on the baseline bilirubin level. For bilirubin levels < 3 and 3.5–12 mg/dl, the exposure to T was 3.3 and 8.5 fold that in healthy subjects (historical control), due to reduced clearance. Compared to patients with acute heart failure, the relative exposure was 1.2 and 3.2 fold, respectively. Exposure to ET-1 increased dose proportionally and an indirect response model could describe the relationship between T and ET-1. The IC50 was independent of the severity of the disease. In conclusion, adjustment of the dosing regimen of T in cirrhotic patients, based on bilirubin levels, is warranted. Clinical Pharmacology & Therapeutics (2004) 75, P31–P31; doi: 10.1016/j.clpt.2003.11.119
A hybrid quantum photonic interface for solid state qubits (2011)

Optical nanocavities enable a strong interaction between single photons and single emitters. An appealing application is the construction of a quantum interface for photonic and solid state qubits. Since the material of the solid state qubit is often dierent from the nanocavity, there has been considerable interest in combining the two in a hybrid architecture. We describe our recent development of such a hybrid interface based a Gallium Phosphide photonic crystal nanocavity that is scanned and deterministically coupled to single emitters on a surface. The technique is used to couple the cavity to the nitrogen vacancy center in diamond, an emitter system with optically accessible electron spins and the ability to transfer electronic spin states to nuclear spins.
Synthesis of certainN-aralkyl-N-(1-((cyclohexylamino)methyl)cyclohexyl)benzenamines and benzamides and their anticonvulsant and analgesic potential (2014)

Background and objectivesEpilepsy is a central nervous system disorder, affecting about 1% of the world's population, and is mostly prevalent in developing nations. In addition, many geminally disubstituted cyclohexane derivatives have proven to have anticonvulsant and analgesic activities. The aim of this study was to synthesize a new series of N-aralkyl-N-(1-((cyclohexylamino)methyl)cyclohexyl)benzenamines, 6a-h, and N-(1-((cyclohexylamino)methyl)cyclohexyl)-N-phenyl-substituted benzamides, 8a-g, for the purpose of evaluating their anticonvulsant and analgesic potential. In addition, the in-silico properties of the newly synthesized compounds have been discussed.Materials and methodsStarting from 1-(N-phenylbenzamido and 4-substituted benzamido)cyclohexane carboxylic acids 3a-g, a new series of N-aralkyl-N-(1-((cyclohexylamino)methyl)cyclohexyl)benzenamines, 6a-h, was synthesized through formation of the corresponding methyl esters 4a-g, which underwent complete reduction of both the ester and the tertiary amidic carbonyl groups to afford the desired amino alcohols, 5a-g. Condensation of the corresponding mesylate esters with cyclohexylamine gave the target diamines 6a-g. Also, the alcohols 7a-g were achieved from 3a-g using NaBH 4 without affecting the amidic group, followed by preparation of the corresponding intermediate mesylate esters, which reacted with cyclohexylamine to yield the benzamidecyclohexyl amines 8a-g. The anticonvulsant and analgesic properties of 6a-h and 8a-h were studied using the pentylenetetrazole screening test and the hot-plate technique, respectively.Results and conclusionThe results of the present study revealed that the most active compounds that exhibited remarkable 100% protection in mice were 6b , 6d , 6e , 8a, 8b , 8f and 8h, compared with diphenylhydantoin sodium and valproic acid, which were used as reference drugs. Both N-aralkyl-N-(1-((cyclohexyl amino)methyl)cyclohexyl)benzenamine and N-(1-((cyclohexylamino)methyl)cyclohexyl)-N-phenyl-substituted benzamide series, 6a-h and 8a-h, displayed significant antinociceptive effects. However, the 6a-h series showed higher potential than the 8a-h one. The results of the in-silico studies for the newly synthesized compounds showed that compounds 6c , 6e , 6h , 8e , 8f and 8h exhibit low mutagenic, tumorigenic, reproductive and medium irritant effect, as well as good drug-likeness and drug score.
Trasient GaAs Plasmonic Metasurfaces at Terahertz Frequencies. (2017)

Abstract not provided.
Liquid crystal polymers containing macroheterocyclic ligands. 4. Synthesis of mesomorphic polymers containing crown ethers by cationic cyclocopolymerization of 1,2-bis(2-ethenyloxyethoxy)benzene with mesogenic vinyl ethers (1990)

Cationic cyclopolymerization, polymerization and/or cyclocopolymerization of 1,2-bis(2-ethenyloxyethoxy)benzene (DVE), 11- [(4′-cyano-4-biphenyl)oxy]undecanyl vinylether (CVE), and 3 - [2 - (1,2,2- trifluoroethoxy - 2 - (4- methoxy - 4′- (α - methylstilbene)oxy)) - 1 - (trifluorometh - yl)trifluoroethoxy] - 1 - [2-(ethenyloxy)ethoxy]-2,2,3,3-tetrafluoropropane (MVE) initiated with H2O/EtAlCl2/S(CH3)2 lead to polymers and copolymers with narrow molecular weight distribution. Poly (DVE) is amorphous, while poly(CVE) and poly(MVE) display a SA and crystalline mesophase. The poly(DVE-co-MVE)s are amorphous. Poly(DVE-co-CVE)s containing 50 mol % and above of CVE structural units displays a SA mesophase.
Inhibition of autophagic flux by S-nitrosylation of SQSTM1/p62 promotes neuronal secretion and cell-to-cell transmission of SNCA/α-synuclein in Parkinson disease and Lewy body dementia (2022)

Autophagy (in the form of macroautophagy) is the major intracellular protein quality control system for removal of damaged organelles and abnormally aggregated proteins. We and others have shown that dysregulated autophagic pathways contribute to accumulation and spread of misfolded proteins in many neurodegenerative disorders, including Parkinson disease (PD) and Lewy body dementia (LBD). Additionally, generation of excessive reactive oxygen and nitrogen species, such as nitric oxide (NO), accelerates neuronal and synaptic damage mediated, at least in part, via aberrant protein S-nitrosylation. Using cell-based models, including human induced pluripotent stem cell (hiPSC)-derived neurons, CRISPR-Cas9 technology, and transgenic PD/LBD mice, plus vetting in human postmortem brains, we found that S-nitrosylation of the autophagic receptor protein SQSTM1/p62 (forming SNO-SQSTM1/p62) inhibits autophagic flux, thus contributing to accumulation of misfolded SNCA/α-synuclein. Consequently, this impairment in autophagy increases extracellular vesicle-dependent secretion and spread of aggregated SNCA. Taken together, our evidence suggests that aberrant formation of SNO-SQSTM1/p62 represents a pathogenic event contributing not only to inhibition of autophagic flux and potentiation of neuronal damage, but also to propagation of α-synucleinopathy between cells in the diseased brain.
Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes (2012)

The mechanisms underlying the immunomodulatory effects of mesenchymal stem cells (MSCs) have been investigated under extreme conditions of strong T cell activation, which induces the rapid death of activated lymphocytes. The objective of this study was to investigate these mechanisms in the absence of additional polyclonal activation. In co-cultures of peripheral mononuclear blood cells with human MSCs (hereafter referred to as hMSCs), we observed a striking decrease in the level of CD8 expression on CD8+ cells, together with decreased expression of CD28 and CD44, and impaired production of IFN-gamma and Granzyme B. This effect was specific to hMSCs, because it was not observed with several other cell lines. Downregulation of CD8 expression required CD14+ monocytes to be in direct contact with the CD8+ cells, whereas the effects of hMSCs on the CD14+ cells were essentially mediated by soluble factors. The CD14+ monocytes exhibited a tolerogenic pattern when co-cultured with hMSCs, with a clear decrease in CD80 and CD86 co-stimulatory molecules, and an increase in the inhibitory receptors ILT-3 and ILT-4. CD8+ cells that were preconditioned by MSCs had similar effects on monocytes and were able to inhibit lymphocyte proliferation. Injection of hMSCs in humanized NSG mice showed similar trends, in particular decreased levels of CD44 and CD28 in human immune cells. Our study demonstrates a new immunomodulation mechanism of action of hMSCs through the modulation of CD8+ cells towards a non-cytotoxic and/or suppressive phenotype. This mechanism of action has to be taken into account in clinical trials, where it should be beneficial in grafts and autoimmune diseases, but potentially detrimental in malignant diseases.
Materials and methods for autonomous restoration of electrical conductivity (2023)

An autonomic conductivity restoration system includes a solid conductor and a plurality of particles. The particles include a conductive fluid, a plurality of conductive microparticles, and/or a conductive material forming agent. The solid conductor has a first end, a second end, and a first conductivity between the first and second ends. When a crack forms between the first and second ends of the conductor, the contents of at least a portion of the particles are released into the crack. The cracked conductor and the released contents of the particles form a restored conductor having a second conductivity, which may be at least 90% of the first conductivity.
Extrapolation of DC device lifetime in body-floating and body-grounded SOI MOSFETS (2002)

The extrapolated dc lifetime of both body-floating and body-grounded partially-depleted SOI n-MOSFETs was demonstrated to be similar when stress conditions corresponding to realistic service conditions were used. Under these stress conditions, no special SOI-related effects exist and floating-body devices can be used for accelerated lifetime measurements.