gebhart/patrepeval huggingface dataset:
Emerging drugs for the treatment of vitiligo (2020)

<b>Introduction</b>: Vitiligo is a relatively common autoimmune depigmenting disorder of the skin. There has been a great advance in understanding the pathological basis, which has led to the development and utilization of various new molecules in treating vitiligo. This review aims at a comprehensively describing the treatments available and the emerging treatment aspects and the scope for future developments.<b>Areas covered</b>: This study comprehensively summarizes the current concepts in the pathogenesis of vitiligo with special focus on the cytokine and signaling pathways, which are the targets for newer drugs. JAK kinase signaling pathways and the cytokines involved are the focus of vitiligo treatment in current research, followed by antioxidant mechanisms and repigmenting mechanisms. Topical immunosuppressants may be an alternative to steroids in localized vitiligo. Newer repigmenting agents like basic fibroblast growth factors, afamelanotide have been included and a special emphasis is laid on the upcoming targeted immunotherapy.<b>Expert opinion</b>: The treatment of vitiligo needs to be multimodal with emphasis on targeting different limbs of the pathogenesis. Topical and oral JAK inhibitors are the most promising new class of drugs currently available for treating vitiligo and acts best in conjunction with NB-UVB.
Antimony Delta Doping by Scanning Transmission Electron Microscopy and Electron Energy Loss Spectroscopy (1999)

Abstract MBE techniques allow the fabrication of exceptionally sharp compositional changes such as delta doped layers in semiconductors. Producing these spatially confined doped layers is critical to many innovative device designs. The spatial confinement of these delta doped structures can be less than the measurement resolution of the currently standard SIMS and RBS techniques. This allows only the upper limits on the layer width to be measured. These SIMS and RBS methods are also inadequate for the two dimensional information desired for future device design and development. More recently developed techniques such as Scanning Capacitance Microscopy and spreading resistance measurement give two dimensional information but have similar spatial resolution issues. The Z-contrast nature of Annular Dark Field (ADF) imaging with the complimentary technique of Electron Energy Loss Spectroscopy (EELS) in the Scanning Transmission Electron Microscope (STEM) shows promise for two dimensional dopant profiling with spatial resolution on the atomic scale.
Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels (2003)

KCNQ1 K+ channels in humans are important for repolarization of cardiac action potentials and for K+ secretion in the inner ear. The pore-forming channel subunits form heteromeric complexes with small regulatory subunits of the KCNE family, in particular with KCNE1 to form channels that conduct a slow delayed rectifier K+ current, IKs. This association leads to alteration of biophysical properties, including a slowing of activation, a suppression of inactivation and an increase of the apparent single-channel conductance. In addition, inward Rb+ currents conducted by homomeric KCNQ1 channels are about threefold larger than K+ currents, whereas heteromeric KCNQ1-KCNE1 channels have smaller inward Rb+ currents compared to K+ currents. We determined inactivation properties and compared K+ vs. Rb+ inward currents for channels formed by co-assembly of KCNQ1 with KCNE1, KCNE3 and KCNE5, and for homomeric KCNQ1 channels with point mutations in the pore helix S5 or S6 transmembrane domains. Several of the channels with point mutations eliminated the apparent inactivation of KCNQ1, as described previously (Seebohm et al. 2001). We found that the extent of inactivation and the ratio of Rb+/K+ currents were positively correlated. Since the effect of Rb+ on the current size has been shown previously to be related to a fast 'flickery' process, our results suggest that inactivation of KCNQ1 channels is related to a fast flicker of the open channel. A kinetic model incorporating two open states, no explicit inactivated state and a fast flicker that is different for the two open states is able to account for the apparent inactivation and the correlation of inactivation and large Rb+ currents. We conclude that an association between KCNQ1 and KCNE subunits or removal of inactivation by mutation of KCNQ1 stabilizes the open conformation of the pore principally by altering an interaction between the pore helix and the selectivity filter and with S5/S6 domains.
Transient Frequency-Domain Thermal Measurements With Applications to Electronic Packaging (2012)

Non-uniform power distribution, increased die-size, and multiple-chip modules present new challenges for the thermal management of modern integrated circuit (IC) packages. Thermal characterization techniques capable of resolving partial thermal resistances at the component level have received increased emphasis in development of advanced packaging technologies. This paper aims to develop a practical method for thermal characterization of IC packages using the frequency-domain measurement technique as a complementary technique to the widely used time-domain thermal transient measurement technique. This paper discusses practical implementation of the technique and demonstrates both thermal modeling and experimental results. Thermal impedances measured in frequency-domain yield the structure function, which describes the dynamic thermal response of the device based on thermal RC network analysis. Various applications of this technique in thermal characterization of the IC packages subjected to field conditions are also discussed.
Inappropriate Sinus Tachycardia After Radiofrequency Ablation of Para‐Hisian Accessory Pathways (1997)

IST is a relatively frequent complication after RFA of para-Hisian APs: it is generally short-lasting and usually does not require any treatment. IST after catheter ablation is likely to depend upon transient parasympathetic denervation of the sinus node.
Is Hyperglycemia Associated with Frailty Status in Older Women? (2009)

Hyperglycemia is associated with greater prevalence of prefrail and frail status; BMI, inflammation, and comorbidities do not explain the association. Longitudinal research and study of alternative pathways are needed.
Single-cell expression of Cxcl9, Arg1, and Ido1 RNAs in splenic macrophages from uninfected and <i>L</i>. <i>donovani</i> infected hamsters. (2017)

&lt;p&gt;The single-cell expression of M1-associated (Ido1 and Cxcl9) and M2-associated (Arg1) mRNA transcripts and CD68 in splenic macrophages from uninfected (row A) and &lt;i&gt;L&lt;/i&gt;. &lt;i&gt;donovani&lt;/i&gt; infected hamsters (rows B, C, and D) was determined by &lt;i&gt;in situ&lt;/i&gt; amplification and fluorescence hybridization. To determine co-expression, cells were hybridized with fluorescent probes specific to CD68, CXCL9, and Arginase 1 (upper panel) or CD68, IDO1, and Arginase 1 (lower panel) and imaged using confocal microscopy. Nuclei were detected by DAPI staining and cellular morphology by Differential interference contrast (DIC) microscopy. In some cases, parasite nuclei could be seen adjacent to macrophage nuclei (indicated by white arrowheads in the DAPI stained cells). The percent of single-positive and double-positive cells was calculated by counting 100 CD68-positive cells. Uninfected cells (row A) were negative for CXCL9, IDO1, and Arginase 1.&lt;/p&gt;
A Structure–Activity Study of Aromatic Acid Modulators for the Synthesis of Zirconium-Based Metal–Organic Frameworks (2022)

Acid modulation is among the most widely employed methods for preparing metal-organic frameworks (MOFs) that are both stable and highly crystalline, yet there exist few guiding principles for selecting the optimal modulator for a given system. Using the Zr-based MOFs UiO-66 and UiO-68-Me<sub>2</sub> (UiO = Universitetet i Oslo) as representative materials, here we present for the first time an in-depth structure-activity study of acid modulators and identify key principles of modulation for the synthesis of highly crystalline Zr-MOFs. By applying whole pattern fitting of powder X-ray diffraction (PXRD) patterns as a technique for evaluating modulator efficacy, complemented by scanning electron microscopy (SEM), <sup>1</sup>H NMR, and thermogravimetric analysis (TGA), we demonstrate that the key to effective modulation is competition between the linker and modulator for coordination to the Zr secondary building units (SBUs). Specifically, we illustrate that a close match in p<i>K</i> <sub>a</sub> and structure between the linker and modulator favors larger and more well-defined crystallites, particularly with sterically unhindered aromatic acid modulators. Based on our findings, we demonstrate that 5-membered heteroaromatic carboxylic acids are among the most efficient acid modulators identified to date for the synthesis of several representative Zr-MOFs with <b>fcu</b> net topologies. In addition, we find that coordination modulation is superior to exogenous acid modulation at higher modulator concentrations. Finally, we compare <sup>1</sup>H NMR and TGA as data-driven methods for quantifying linker deficiencies in modulated MOF syntheses. The guiding principles established herein have critical implications for the scalable and controllable synthesis of highly crystalline and stable MOFs relevant to chemical separations, gas storage, and catalysis.
Enhancement of hydrodynamic flow noise radiation by the regulation of air bubbles in a turbulent water jet. (1992)

Experimental results show that the near-field hydrodynamic radiated flow noise (generated by a turbulent submerged circular water jet) is enhanced when the turbulent flow is modified to become a two-phase flow containing air bubbles. Acoustic intensity spectra, in the frequency band between 20 and 7000 Hz, are measured using a digital spectrum analyzer from signals generated by a hydrophone placed at the position of Z=4d and R=4d. Here, Z and R are the axial and radial positions from the nozzle exit, respectively. The water velocity is 12 m/s at the nozzle exit (of diameter d=0.635 cm). An amplification factor defined by the ratio of intensities Itwo-phase flow/Ifluid flow is measured as a function of the void fraction β of the air bubbles in an effort to verify the theoretical amplification predictions made by Crighton and Ffowcs-Williams [J. Fluid Mech. 36, 585–603 (1969)] and more recently by Prosperetti [J. Acoust. Soc. Am. 84, 1042–1054 (1988)]. A short video-tape of the experiment will be shown. [Work supported by the National Center for Physical Acoustics, ONR, and the Naval Academy Research Council.]
Lentigo maligna (melanoma): A systematic review and meta‐analysis on surgical techniques and presurgical mapping by reflectance confocal microscopy (2023)

Because of an increased risk of local recurrence following surgical treatment of lentigo maligna (melanoma) (LM/LMM), the optimal surgical technique is still a matter of debate. We aimed to evaluate the effect of different surgical techniques and reflectance confocal microscopy (RCM) on local recurrence and survival outcomes. We searched MEDLINE, Embase and PubMed databases through 20 May 2022. Randomized and observational studies with ≥10 lesions were eligible for inclusion. Bias assessment was performed using the Methodological Index for Non-Randomized Studies instrument. Meta-analysis was performed for local recurrence, as there were insufficient events for the other clinical outcomes. We included 41 studies with 5059 LM and 1271 LMM. Surgical techniques included wide local excision (WLE) (n = 1355), staged excision (n = 2442) and Mohs' micrographic surgery (MMS) (n = 2909). Six studies included RCM. The guideline-recommended margin was insufficient in 21.6%-44.6% of LM/LMM. Local recurrence rate was lowest for patients treated by MMS combined with immunohistochemistry (<1%; 95% CI, 0.3%-1.9%), and highest for WLE (13%; 95% CI, 7.2%-21.6%). The mean follow-up varied from 27 to 63 months depending on surgical technique with moderate to high heterogeneity for MMS and WLE. Handheld-RCM decreased both the rate of positive histological margins (p < 0.0001) and necessary surgical stages (p < 0.0001). The majority of regional (17/25) and distant (34/43) recurrences occurred in patients treated by WLE. Melanoma-associated mortality was low (1.5%; 32/2107), and more patients died due to unrelated causes (6.7%; 107/1608). This systematic review shows a clear reduction in local recurrences using microscopically controlled surgical techniques over WLE. The use of HH-RCM showed a trend in the reduction in incomplete resections and local recurrences even when used with WLE. Due to selection bias, heterogeneity, low prevalence of stage III/IV disease and limited survival data, it was not possible to determine the effect of the different surgical techniques on survival outcomes.
Velocity variations in a regulated river channel (2013)

The conversion of kinetic energy in water currents into electricity has gained great attention the past years. The conversion systems are stand-alone units that typically consist of a turbine, driven by the water stream, with a generator connected to it. At the Division of Electricity at Uppsala University, research on a hydrokinetic energy conversion system is ongoing. In March 2013, a full-scale prototype was deployed in the river Dalalven at Soderfors.This thesis is based on seven papers where the aim has been to assess the resource for hydrokinetic energy conversion. The existing hydrokinetic energy resource assessments in Scandinavia have been limited to the tidal energy found along the coast of Norway. The results from these assessments were unreliable, due to the lack of velocity data and the simple methodology used. One objective of this thesis was thus to measure the velocity in both tidal current and rivers, and evaluate models for predicting these values. Another objective was to study implications of the conversion of hydrokinetic energy, such as the degree of utilisation and the conversion efficiency, and effects on the surrounding flow and water level.River discharge data was shown to give a good approximation of the velocity. However, non-linear behaviour of the velocity upon changing discharge cannot be approximated with discharge data. A model using tidal level data to estimate the velocity in fjord entrances was evaluated, and the model was shown to adequately estimate the cross-sectional average velocity. However, the maximum velocity in the horizontal cross-sectional profile was significantly higher than the cross-sectional average, and the model, in its current form, was not recommended to be used for resource estimations.A high degree of utilisation, around 50%, was shown to be possible to achieve in both tidal and river currents, provided that the rated velocity is chosen properly. It was concluded that the rated velocity should be higher than the mean value, but lower than the value giving optimal conversion efficiency. Converting the kinetic energy of the flow to electricity in a river was shown to alter the water level upstream of the turbine. However, the increase in water level, caused by a hydrokinetic energy converter, was shown to be negligible compared to background friction.
Species Specificity of Ectopic Bone Formation Using Periosteum-Derived Mesenchymal Progenitor Cells (2006)

To investigate novel cell-based bone-engineering approaches using rabbit as a preclinical animal model, we compared the osteogenic potential of rabbit periosteum-derived cells (RPDCs) and human periosteum-derived cells (HPDCs) in vitro and in vivo. Adherent periosteal cells from both species were expanded in vitro and subsequently treated with osteogenic medium or bone morphogenetic protein 6 (BMP6). Alkaline phosphatase (ALP) activity was measured, and alizarin red staining was performed to evaluate osteogenic differentiation. In vivo ectopic bone formation was assessed by seeding 5x10(6) periosteal cells, grown in osteogenic conditions, in a Collagraft carrier and subsequent implantation subcutaneously in athymic mice. In vitro, growth analysis indicated that RPDCs expanded faster and were smaller than HPDCs under the same culture conditions. Osteogenic medium did not affect the ALP activity of HPDCs or RPDCs. In contrast, BMP6 stimulated ALP activity in cultured RPDCs and HPDCs but at different rates. In vivo, HPDCs gave rise to extensive bone formation, whereas RPDCs failed to make bone. In vivo, cell tracking revealed that engraftment and survival of HPDCs and RPDCs after 8 weeks in the implant were limited. Some HPDCs were incorporated into the newly formed bone. RPDCs and HPDCs displayed distinct growth characteristics and osteogenic differentiation capacity in vitro and in vivo under the culture conditions used. Our data indicate potential limitations of use of the rabbit as a preclinical model for cell-based treatments for bone repair.
Ping-Pong Reduction Using Sub Cell Movement Detection (2012)

In this paper we demonstrate an effective way to classify repeated handovers (ping-pongs) in mobile broadband networks. The paper also presents a method that can significantly reduce unwanted ping-pongs in the network. The method combines a sub cell movement detection method and ping-pong detection to decide when it is most effective to apply handover threshold tuning (pinning) without increasing the risk of late or failed handovers. The algorithm was evaluated based on live network measurements.
Essential Role of Transcription Factor Nuclear Factor-κB in Regulation of Interleukin-8 Gene Expression by Nitrite Reductase fromPseudomonas aeruginosain Respiratory Epithelial Cells (1999)

Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we have reported that nitrite reductase from P. aeruginosa induces the production of IL-8 in respiratory cells, including bronchial epithelial cells. To determine the molecular mechanism(s) of nitrite reductase-induced IL-8 expression in respiratory cells, A549 epithelial cells were transfected with plasmids containing serial deletions of the 5'-flanking region of the IL-8 gene and then exposed to nitrite reductase. Nitrite reductase significantly enhanced IL-8 gene promoter-driven reporter activity. This increased IL-8 gene expression was inhibited by mutating the nuclear factor-kappaB (NF-kappaB) binding element. Nitrite reductase enhanced nuclear localization of the NF-kappaB binding complex. Furthermore, nitrite reductase induced the degradation of IkappaBalpha, the major cytoplasmic inhibitor of NF-kappaB, and the expression of IkappaBalpha mRNA. These data support the critical role of the activation of NF-kappaB in nitrite reductase-induced IL-8 gene expression in airway epithelium.
Progress on retinal image analysis for age related macular degeneration (2013)

Age-related macular degeneration (AMD) is the leading cause of vision loss in those over the age of 50 years in the developed countries. The number is expected to increase by ∼1.5 fold over the next ten years due to an increase in aging population. One of the main measures of AMD severity is the analysis of drusen, pigmentary abnormalities, geographic atrophy (GA) and choroidal neovascularization (CNV) from imaging based on color fundus photograph, optical coherence tomography (OCT) and other imaging modalities. Each of these imaging modalities has strengths and weaknesses for extracting individual AMD pathology and different imaging techniques are used in combination for capturing and/or quantification of different pathologies. Current dry AMD treatments cannot cure or reverse vision loss. However, the Age-Related Eye Disease Study (AREDS) showed that specific anti-oxidant vitamin supplementation reduces the risk of progression from intermediate stages (defined as the presence of either many medium-sized drusen or one or more large drusen) to late AMD which allows for preventative strategies in properly identified patients. Thus identification of people with early stage AMD is important to design and implement preventative strategies for late AMD, and determine their cost-effectiveness. A mass screening facility with teleophthalmology or telemedicine in combination with computer-aided analysis for large rural-based communities may identify more individuals suitable for early stage AMD prevention. In this review, we discuss different imaging modalities that are currently being considered or used for screening AMD. In addition, we look into various automated and semi-automated computer-aided grading systems and related retinal image analysis techniques for drusen, geographic atrophy and choroidal neovascularization detection and/or quantification for measurement of AMD severity using these imaging modalities. We also review the existing telemedicine studies which include diagnosis and management of AMD, and how automated disease grading could benefit telemedicine. As there is no treatment for dry AMD and only early intervention can prevent the late AMD, we emphasize mass screening through a telemedicine platform to enable early detection of AMD. We also provide a comparative study between the imaging modalities and identify potential study areas for further improvement and future research direction in automated AMD grading and screening.
Channel Temperature Analysis of GaN HEMTs With Nonlinear Thermal Conductivity (2015)

This paper presents an enhanced, closed-form expression for the thermal resistance, and thus, the channel temperature of AlGaN/gallium nitride (GaN) HEMTs, including the effect of the temperature-dependent thermal conductivity of GaN and SiC or Si substrates. In addition, the expression accounts for temperature increase across the die-attach. The model's validity is verified by comparing it with experimental observations. The model results also compare favorably with those from finite-element numerical simulations across the various device geometric and material parameters. The model provides a more accurate channel temperature than that from a constant thermal conductivity assumption; this is particularly significant for GaN/Si HEMTs where the temperature rise is higher than in GaN/SiC. The model is especially useful for device and monolithic microwave integrated circuit designers in the thermal assessment of their device design iterations against required performance for their specific applications.