gebhart/patrepeval huggingface dataset:
Doxorubicin‐induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2 (2020)

Clinical dose of doxorubicin (100 nM) induced cellular senescence and various secretory phenotypes in breast cancer and normal epithelial cells. Herein, we reported the detailed mechanism underlying ginsenoside Rh2-mediated NF-κB inhibition, and mitophagy promotion were evaluated by antibody array assay, western blotting analysis, and immunocytostaining. Ginsenoside Rh2 suppressed the protein levels of TRAF6, p62, phosphorylated IKK, and IκB, which consequently inactivated NF-κB activity. Rh2-mediated secretory phenotype was delineated by the suppressed IL-8 secretion. Senescent epithelial cells showed increased level of reactive oxygen species (ROS), which was significantly abrogated by Rh2, with upregulation on SIRT 3 and SIRT 5 and subsequent increase in SOD1 and SOD2. Rh2 remarkably favored mitophagy by the increased expressions of PINK1 and Parkin and decreased level of PGC-1α. A decreased secretion of IL-8 challenged by mitophagy inhibitor Mdivi-1 with an NF-κB luciferase system was confirmed. Importantly, secretory senescent epithelial cells promoted the breast cancer (MCF-7) proliferation while decreased the survival of normal epithelial cells demonstrated by co-culture system, which was remarkably alleviated by ginsenoside Rh2 treatment. These data included ginsenoside Rh2 regulated ROS and mitochondrial autophagy, which were in large part attributed to secretory phenotype of senescent breast epithelial cells induced by doxorubicin. These findings also suggested that ginsenoside Rh2 is a potential treatment candidate for the attenuation of aging related disease.
A photometric method for the estimation of the oil yield of oil shale (1951)

A method is presented for the distillation and photometric estimation of the oil yield of oil-bearing shales. The oil shale is distilled in a clesed test tube sad the oil extracted with toluene. The optical density cf the toluene extract is used in the estimation of oil content and is converted to percentage of cil by reference to a standard carve. This curve is obtaired. by relating the oil yields determined by the Fischer assay .method to, the optical denzity of the toluene extract of the oil evolved by the new procedure. The new method gives results similar to those obtained by the Fischer assay method in a much shorter time. The applicability of the new method to oil-bearing shale and phoaphatic shale has }-Fes. tested.
Size and charge effect of guest cations in the formation of polyoxopalladates: a theoretical and experimental study (2017)

The development of rational synthetic procedures with desired nuclearity and high selectivity is a critical issue in inorganic chemistry. Here we demonstrate a comprehensive understanding of the template effect induced by metal cations in the formation mechanism of the class of polyoxopalladates ({MPd<sub>12</sub>L<sub>8</sub>} nanocube and {MPd<sub>15</sub>L<sub>10</sub>} nanostar) by combining computational and experimental techniques. The capture of a M <sup><i>n</i>+</sup> guest ion by a peripheral palladium(ii)-oxo shell leads to a competition between the parent Pd<sup>2+</sup> addenda ion and the respective guest metal ion. The present study reveals that (i) the selection of the incorporated guest ion has a thermodynamic control, (ii) the main factors governing the formation of a particular polyanion are the charge and size of the guest cation, (iii) the electrostatic interaction between the cation and the surrounding oxo ligands and (iv) the dehydration ability of the cation. As expected from the number of observed {M <sup><i>n</i>+</sup>Pd<sub>12</sub>L<sub>8</sub>} species, trivalent cations M<sup>3+</sup> were found to be good templates resulting in several examples of {M<sup>3+</sup>Pd<sub>12</sub>L<sub>8</sub>}, whereas monovalent cations M<sup>+</sup> are much less prone to form {M<sup>+</sup>Pd<sub>12</sub>L<sub>8</sub>}. For tetravalent cations the dehydration energies are very large, however, the formation of {M<sup>4+</sup>Pd<sub>12</sub>L<sub>8</sub>} nanocubes is found to be still energetic favourable. Fully consistent with computational predictions, four novel polyoxo-12-palladates were synthesized: the La<sup>3+</sup>-centered nanocube [LaPd<sub>12</sub>O<sub>8</sub>(PhAsO<sub>3</sub>)<sub>8</sub>]<sup>5-</sup> (<b>LaPd<sub>12</sub>-closed</b>), the La<sup>3+</sup>-centered "open" nanocube [LaPd<sub>12</sub>O<sub>6</sub>(OH)<sub>3</sub>(PhAsO<sub>3</sub>)<sub>6</sub>(OAc)<sub>3</sub>]<sup>3-</sup> (<b>LaPd<sub>12</sub>-open</b>), the Ga<sup>3+</sup>-centered [GaPd<sub>12</sub>O<sub>8</sub>(PhAsO<sub>3</sub>)<sub>8</sub>]<sup>5-</sup> (<b>GaPd<sub>12</sub></b> ), and the In<sup>3+</sup>-analogue [InPd<sub>12</sub>O<sub>8</sub>(PhAsO<sub>3</sub>)<sub>8</sub>]<sup>5-</sup> (<b>InPd<sub>12</sub></b> ). All four compounds were fully characterized in the solid state and in solution by a multitude of physicochemical techniques, including <sup>71</sup>Ga and <sup>115</sup>In NMR as well as mass spectrometry. The experimentally observed selective incorporation of only In<sup>3+</sup> ions in the presence of Ga<sup>3+</sup> and In<sup>3+</sup> confirmed the thermodynamic control of the formation mechanism, which we had predicted by theory.
Intermolecular potential functions and Monte Carlo simulations for liquid sulfur compounds (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermolecular potential functions and Monte Carlo simulations for liquid sulfur compoundsWilliam L. JorgensenCite this: J. Phys. Chem. 1986, 90, 23, 6379–6388Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/j100281a063https://doi.org/10.1021/j100281a063research-articleACS PublicationsRequest reuse permissionsArticle Views1103Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Fully Wireless Implantable Multi-Channel Muscle Stimulator with Closed-Loop Feedback Control (2018)

We have developed an implantable four-channel high-current biphasic stimulator device for controlling the muscles of the hand, and successfully tested it in a non-human primate (NHP). The charge-balanced stimulator features an external unit which connects to a personal computer via WiFi, and provides wireless power and data control commands to the implant across biological tissue. The stimulator obtained realtime grip force from the hand using a force sensor to perform automated closed-loop control of the stimulation amplitude to ensure that we were able to produce sustained gripping force in the hand of the animal in the event of muscle fatigue. The device was encapsulated using a FDA-compliant biocompatible polymer for reliable long-term study. In-vivo experiments performed after the stimulator (with electrodes embedded in different muscles) had been implanted for one month demonstrated that the system was able to evoke, and automatically maintain, a targeted range of gripping force in the animal's hand. Our results demonstrate the utility of our closed-loop muscle stimulator as a neuroprosthesis for restoring functional hand movements in patients with upper-limb peripheral nerve injuries.
Unsupervised Domain Adaptation for Visual Navigation (2020)

Advances in visual navigation methods have led to intelligent embodied navigation agents capable of learning meaningful representations from raw RGB images and perform a wide variety of tasks involving structural and semantic reasoning. However, most learning-based navigation policies are trained and tested in simulation environments. In order for these policies to be practically useful, they need to be transferred to the real-world. In this paper, we propose an unsupervised domain adaptation method for visual navigation. Our method translates the images in the target domain to the source domain such that the translation is consistent with the representations learned by the navigation policy. The proposed method outperforms several baselines across two different navigation tasks in simulation. We further show that our method can be used to transfer the navigation policies learned in simulation to the real world.
Simultaneous amplification andcompression of picosecond pulses to50kW inErfiber (2007)

200 ~ ~~~~ pulse energy (nJ)- 10S 1480m imodematched splice * S E~~~~~~18 0nm:. ._ E |. <1 serlwdh(m 100~~~~~~~~~~~~. Raman avera~~~~~~~u 06 gepower(mW) I pulse0.4er.(e)Pulse 0pu (U~~~~~~~~~~~~~~~~~~~~~~~ e 0nd temporal compression (inset 20 Fig.l(d))3to close tobandwidth limit. Athighernonlinearitpcrlwdh(m t.5ral 0.c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c cu 0.2~~~~~~~ 23
External cardioversion of atrial fibrillation: comparison of biphasic vs monophasic waveform shocks (2001)

This study suggests that at the same energy level of 150 J, biphasic impedance compensating waveform shocks are superior to monophasic damped sine waveform shocks cardioversion of atrial fibrillation.
Mischief (2008)

Mischief is a system to support traditional classroom practices between a remote instructor and a group of collocated students. Meant for developing regions, each student in the classroom is given a mouse and these are connected to a single machine and shared display. We present observations of teaching practices in rural Chinese classrooms that led to Mischief's design. Mischief's user interface, with which scores of collocated students can interact simultaneously, supports anonymous responses, communicates focus of attention, and maintains the role of the instructor. Mischief is an extensible platform in which Microsoft PowerPoint slides, used commonly in developing regions, are made interactive. We setup a controlled environment where Mischief was used by classrooms of children with a remote math instructor. The results from the study provided insight into the usability and capacity of the system to support traditional classroom interactions. These observations were also the impetus for a redesign of several components of Mischief and are also presented. These findings contribute both a novel system for synchronous distance education in an affordable manner and design insights for creators of related systems.
Shared Data Clusters: Scaleable, Manageable, and Highly Available Systems (VERITAS Series) (2002)

From the Publisher:
Clustering is a vital methodology in the data storage world. Its goal is to maximize cost-effectiveness, availability, flexibility, and scalability. Clustering has changed considerably for the better due to Storage Area Networks, which provide access to data from any node in the cluster.
Explains how clusters with shared storage work and the components in the cluster that need to work together Reviews where a cluster should be deployed and how to use one for best performance Author is Lead Technical Engineer for VERITAS Cluster File Systems and has worked on clusters and file systems for the past ten years
Innovative design of scanning antennas using electronically reconfigurable metasurfaces (2014)

Metasurfaces (MTS's) can be considered nowadays a promising way for designing a large class of electromagnetic devices, such as antennas, beamsplitters or planar lenses. They consist of a dense arrangement of sub-wavelength elements, organized in such a way that unusual electromagnetic properties can be achieved. Among of the main advantages of MTS's are their low cost, low profile and realization simplicity; in fact, PCB technology can be profitably used to fabricate MTS's consisting of elements printed on a grounded dielectric slab.
Erratum: Somatostatin receptor expression, tumour response and quality of life in patients with advanced hepatocellular carcinoma treated with long-acting octreotide (2007)

Correction to: British Journal of Cancer (2006) 95, 853–861. doi: 10.1038/6603325 Owing to an error on the author's part, the full list of authors was not given when the paper was originally published. The authors would like the authorship of the paper to be properly reflected; the full, accurate list of authors is therefore listed, above.
Activation-Dependent Epitopes in the Terminal Complement Pathway (1989)

Assembly of the terminal complement complex (TCC) during complement activation is associated with considerable antigenic changes in the individual C5, C6, C7, C8 and C9 components. Numerous neoepitopes specific for the TCC are exposed. Similarly, native-restricted epitopes specific for the nonactivated components are concealed in the TCC. The present paper reviews these antigenic changes with special reference to available monoclonal antibodies and their utilization in assays to detect and quantify the TCC. Application of such assays in clinical medicine is discussed. Finally, a recommended terminology for the terminal complement pathway is put forward.
Chemokines Accumulate in the Lungs of Rats with Severe Pulmonary Embolism Induced by Polystyrene Microspheres (2003)

Pulmonary thromboembolism (PEm) is a serious and life threatening disease and the most common cause of acute pulmonary vascular occlusion. Even following successful treatment of PEm, many patients experience long-term disability due to diminished heart and lung function. Considerable damage to the lungs presumably occurs due to reperfusion injury following anti-occlusive treatments for PEm and the resulting chronic inflammatory state in the lung vasculature. We have used a rat model of irreversible PEm to ask whether pulmonary vascular occlusion in the absence of reperfusion is itself sufficient to induce an inflammatory response in lungs. By adjusting the severity of the vascular occlusion, we were able to generate hypertensive and nonhypertensive PEm, and then examine lung tissue for expression of CXC and C-C chemokine genes and bronchoalveolar lavage (BAL) fluid for the presence of chemokine proteins. Hypertensive and nonhypertensive PEm resulted in increased expression of both CXC and C-C chemokines genes in lung tissues. Hypertensive PEm was also associated with a 50-100-fold increase in protein content in lung BAL fluid, which included the CXC chemokines cytokine-induced neutrophil chemoattractant and macrophage-inflammatory protein 2. The presence of chemokines in BALs was reflected by a potent neutrophil chemotactic activity in in vitro chemotaxis assays. Abs to cytokine-induced neutrophil chemoattractant blocked the in vitro neutrophil chemotactic activity of BAL by 44%. Our results indicate that the ischemia and hypertension associated with PEm are sufficient to induce expression of proinflammatory mediators such as chemokines, and establish a proinflammatory environment in the ischemic lung even before reperfusion.
ChemInform Abstract: A Facile Synthesis of 2‐Substituted N‐tert‐Butoxycarbonyl‐N‐methyl‐1,3‐ propanediamines, Key Intermediates for the Preparation of Triplex DNA‐ Specific Intercalators. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
STRID: Scalable Trigger-Based Route Incidence Diagnosis (2008)

As the Internet steadily increases in importance, it is still based on a quite fragile routing design. From network operators perspective it is therefore crucial to detect end-to- end path performance due to routing outages early to either mitigate them directly or contact other entities to mitigate them. In this work we demonstrate the feasibility of a real-time tool for detecting degraded forwarding performance due to routing problems. Our tool passively monitors the traffic within the network and actively probes paths for which the TCP traffic characteristics indicate a possible routing problem. More importantly, our tool focuses on detecting routing events that actually affect network traffic, which from the network operators' perspective is most relevant. The experimental results based on large-scale measurement in the Internet indicate that our tool effectively detects a significant number of routing outages and forwarding loops.
THE OVERLAPPING MECHANISM OF WEIGHT LOSS RESISTANCE AND REBOUND FROM A SIGNIFICANT WEIGHT LOSS IN OBESE SUBJECTS (2004)

Masuo, K.1,2; Eikelis, N.1; Lambert, E.1; Lambert, G.1; Esler, M.1; Ogihara, T.2 Author Information
A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors (2016)

The combination of these AKT and mTOR inhibitors was safe and feasible in patients with recurrent/refractory pediatric solid tumors.
Radioisotopic tracing of carbon monoxide conversion by anaerobic thermophilic prokaryotes (2007)

The rate of CO conversion by a pure culture of a thermophilic CO-oxidizing, H2-producing bacterium Carboxydocella sp. strain 1503 was determined by the radioisotopic method. The overall daily uptake of 14CO by the bacterium was estimated at 38–56 μmol CO per 1 ml of the culture. A radioisotopic method was developed to separate and quantitatively determine the products of anaerobic CO conversion by microbial communities in hot springs. The new method was first tested on the microbial community from a sample obtained from a hot spring in Kamchatka. The potential rate of CO conversion by the anaerobic microbial community was found to be 40.75 nmol CO/cm3 sediment per day. 85% of the utilized 14CO was oxidized to carbon dioxide; 14.5% was incorporated into dissolved organic matter, including 0.2% that went into volatile fatty acids; 0.5% was used for cell biomass production; and only just over 0.001% was converted to methane.
HfSiON GATE DIELECTRICS FOR LOW-STAND-BY POWER CMOS DEVICES (2004)

In this paper, we review our resent results concerning poly-Si/HfSiON gate stack for low-stand-by power CMOS device fabricated by conventional poly-Si gate process. We discuss the problem of flatband voltage shifts of poly-Si/HfSiON gate stack, the way to improve effective carrier mobility by nitrogen profile engineering in HfSiON film, and reliability and breakdown mechanism of HfSiON film.
Lack of Correlation between Mbo I Restriction Fragment Length Polymorphism of Renin Gene and Essential Hypertension in Japanese. (2001)

Predisposition to essential hypertension is associated with gene polymorphisms of the renin angiotensin system (RAS). Gene polymorphisms of the angiotensinogen and angiotensin converting enzyme genes are known to be risk factors for hypertension, while few studies concerning the renin gene polymorphism have been published. In the present investigation, we carried out a case control study using a Japanese population to examine the genetic influence of the renin gene on the predisposition to hypertension. Patients (n=235) recruited from outpatients at Osaka University Hospital and diagnosed with essential hypertension or receiving long-term antihypertensive medication participated in the study. Normotensive control subjects (n=510) without a history of hypertension and without diabetes mellitus were recruited from the same population, and were sex-matched with experimental subjects. A polymorphism in intron 9 of the human renin gene was determined as the Mbo I restriction fragment length polymorphism (Mbo I-RFLP). There was no significant association between Mbo I-RFLP of the renin gene and predisposition to essential hypertension in Japanese (p>0.05, chi2=2.1). These results suggest that the Mbo I (+) allele of the renin gene does not increase the risk for hypertension in Japanese.
ChemInform Abstract: Rhodium(I)‐Catalyzed “Metallo‐Ene” Cyclizations/β‐Eliminations. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-speed, electronically shuttered solid-state imager technology (invited) (2003)

Electronically shuttered solid-state imagers are being developed for high-speed imaging applications. A 5 cm×5 cm, 512×512-element, multiframe charge-coupled device (CCD) imager has been fabricated for the Los Alamos National Laboratory DARHT facility that collects four sequential image frames at megahertz rates. To operate at fast frame rates with high sensitivity, the imager uses an electronic shutter technology designed for back-illuminated CCDs. The design concept and test results are described for the burst-frame-rate imager. Also discussed is an evolving solid-state imager technology that has interesting characteristics for creating large-format x-ray detectors with short integration times (100 ps to 1 ns). Proposed device architectures use CMOS technology for high speed sampling (tens of picoseconds transistor switching times). Techniques for parallel clock distribution, that triggers the sampling of x-ray photoelectrons, will be described that exploit features of CMOS technology.
Impact of On-Chip Interconnect on the Performance of 3-D Integrated Circuits With Through Silicon Vias: Part I (2016)

Circuit-level models are developed to determine the upper bound on the performance of a 3-D IC link with through silicon vias (TSVs). It is shown that the performance of a 3-D link is limited not only by the on-chip interconnect RC, driver resistance, and TSV capacitance, but also by the current carrying capacity of the on-chip wires connecting the TSV to the input/output (I/O) driver. The models developed in this paper are used to optimize the I/O driver size, the number of on-chip wires connecting the TSV to the driver, and the data-rate to maximize the aggregate bandwidth per unit energy. Furthermore, in order to maximize the aggregate bandwidth of a 3-D link, it is shown that splitting the TSV array into smaller subarrays and placing the I/O drivers closer to the TSVs is better compared with having large TSV arrays.
Long Non-coding RNA T-UCstem1 Controls Progenitor Proliferation and Neurogenesis in the Postnatal Mouse Olfactory Bulb through Interaction with miR-9 (2020)

Neural stem cell populations generate a wide spectrum of neuronal and glial cell types in a highly ordered fashion. MicroRNAs are essential regulators of this process. T-UCstem1 is a long non-coding RNA containing an ultraconserved element, and in vitro analyses in pluripotent stem cells provided evidence that it regulates the balance between proliferation and differentiation. Here we investigate the in vivo function of T-UCstem1. We show that T-UCstem1 is expressed in the forebrain neurogenic lineage that generates interneurons for the postnatal olfactory bulb. Gain of function in neural stem cells increased progenitor proliferation at the expense of neuron production, whereas knockdown had the opposite effect. This regulatory function is mediated by its interaction with miR-9-3p and miR-9-5p. Based thereon, we propose a mechanistic model for the role of T-UCstem1 in the dynamic regulation of neural progenitor proliferation during neurogenesis.