gebhart/patrepeval huggingface dataset:
Abstract 356: Novel conditionally active biologic (CAB) antibody targeting EpCAM demonstrates anti-tumor efficacy in vivo (2019)

Abstract Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion during cell signaling, migration, proliferation, and differentiation. EpCAM is expressed at high levels exclusively in epithelia and epithelial-derived neoplasms, making it a suitable target for many important solid tumor types and cancer stem cells. EpCam expression on normal tissues limits its utility as target for therapeutic antibodies and ADCs due to the potential effects on normal epithelial throughout the body. Conditionally Active Biologics (CAB) technology is a proprietary platform that selects antibodies that bind to target antigens in the context of diseased tissues, but not normal tissues, by taking advantage of the unique conditions in the tumor microenvironment. Using our CAB technology, we have developed CAB antibodies to EpCAM that reversibly bind to recombinant EpCAM and EpCAM expressing cells under select conditions that are present in the tumor microenvironment but not in normal tissues. In vitro and in vivo efficacy data for several anti-EpCAM antibodies and ADCs will be presented and suggest that conditionally active EpCam ADCs generated using the CAB technology will provide drug candidates that have an increased safety margin and therapeutic index in the clinic. Citation Format: Cathy Chang, Gerhard Frey, Leslie Sharp, William (Bill) J. Boyle, Jing Wang, Charles Xing, Haizhen Liu, Christina Wheeler, Marlena Walls, Jay M. Short. Novel conditionally active biologic (CAB) antibody targeting EpCAM demonstrates anti-tumor efficacy in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 356.
Fully-printed phase-compensation method for the outputs of the compact metamaterial dual-band 3-way power-divider (2014)

A compact dual-band 3-way metamaterial power divider with the in-phase outputs is presented. Firstly, fully printed CRLH(composite right and left-handed) 2∶1-unequal and 1∶1-equal power dividers are designed for 900-MHz and 2.4-GHz bands. Secondly, an initial 1∶1∶1 power divider is formed by combining the input of the 2-way equal block into an output of the unequal block, and trimming the interconnection parameters. Thirdly, to have the identical phase at the outputs of the power divider, a printable phase-compensating block line is designed to treat the different phase errors at the 2 frequencies.
Hydrodynamic analysis and optimal design of a wave energy device (2006)

The model of a kind of wave energy device moored on seabed is simplified into a spring-mass-damping system,and then its motion equation is built according to Newton's second law.Boundary element method based on simple Green function is presented to analyze the vertical motion of the buoy that drives a hydraulic pressure device below.Optimal design of external-damping coefficient for attaining the maximum work produced by the buoy is discussed in detail.The result of the optimal design can be used to guide the practical work directly.
Population and hierarchy of active species in gold iron oxide catalysts for carbon monoxide oxidation (2016)

The identity of active species in supported gold catalysts for low temperature carbon monoxide oxidation remains an unsettled debate. With large amounts of experimental evidence supporting theories of either gold nanoparticles or sub-nm gold species being active, it was recently proposed that a size-dependent activity hierarchy should exist. Here we study the diverging catalytic behaviours after heat treatment of Au/FeO<sub>x</sub> materials prepared via co-precipitation and deposition precipitation methods. After ruling out any support effects, the gold particle size distributions in different catalysts are quantitatively studied using aberration corrected scanning transmission electron microscopy (STEM). A counting protocol is developed to reveal the true particle size distribution from HAADF-STEM images, which reliably includes all the gold species present. Correlation of the populations of the various gold species present with catalysis results demonstrate that a size-dependent activity hierarchy must exist in the Au/FeO<sub>x</sub> catalyst.
Endoprostheses for colonic strictures (1998)

The development of new endoprostheses has allowed their adaptation for use in the colon and, perhaps, the distal small bowel. The technology is evolving rapidly and warrants serious consideration in selected patients with large bowel obstruction before embarking on surgery. There is an urgent need for a controlled trial to establish whether such intervention for malignant strictures, potentially curable by surgery, leads to an increased risk of metastatic disease.
Determination of interface width using EELS fine structure changes (1991)

The concept of interfacial width is often invoked in many materials science phenomena which relate to the structure and properties of internal interfaces. The numerical value of interface width is an important input parameter in diffusion equations, sintering theories as well as in many electronic devices/processes. Most often, however, this value is guessed rather than determined or even estimated. In this paper we present a method of determining the effective structural and electronic- structural width of interphase interfaces using low- and core loss fine structure effects in EELS spectra. The specimens used in the study were directionally solidified eutectics (DSEs) in the system; NiO-ZrO 2 (CaO), NiO-Y 2 O 3 and MnO-ZrO 2 (ss). EELS experiments were carried out using a VG HB-501 FE STEM and a Hitachi HF-2000 FE TEM.
Bayesian transduction and Markov conditional mixtures for spatiotemporal interactive segmentation (2009)

In this paper we propose a novel transductive learning machine for spatiotemporal classification casted as an interactive segmentation problem. We present Markov conditional mixtures of naive Bayes models with spatiotemporal regularization constraints in a transductive learning and inference framework. The proposed model extends on previous work to account for non independent and identically distributed (i.i.d.) sequential data by imposing the learning and inference problem w.r.t. time. The multimodal mixture assumption on the class-conditional likelihood for each covariate feature domain in conjunction with spatiotemporal regularization constraints allow us to explain more complex distributions required for classification in multimodal longitudinal brain imagery. We evaluate the proposed algorithm on multimodal temporal MRI brain images using ROC statistics and report preliminary results.
Ada Adoption Handbook: A Program Manager’s Guide (1992)

The ADA Adoption Handbook provides program managers with information about how best to tap ADA's strengths and manage the transition to fully using this software technology. Although the issues are complex, they are not all unique to ADA. Indeed, many of the issues addressed in this handbook must be addressed when developing any software-intensive system in any programming language. The handbook addresses the advantages and risks in adopting ADA. Significant emphasis has been placed on providing information and suggesting methods that will help program and project managers succeed in using ADA across a broad range of application domains. The handbook focuses on the following topics: ADA's goals and benefits; program management issues; implications for education and training; software tools with emphasis on compiler validation and quality issues; the state of ADA technology as it related to system design and implementation; and the pending update of the ADA language standard (ADA 9X).
Half-Sandwich Ruthenium(II) Catalysts for C−C Coupling Reactions between Alkenes and Diazo Compounds (2000)

The complex [(η5-C5H5)Ru(PPh3)2Cl] (1) and other readily available ruthenium(II) derivatives of general formula [(η5-ligand)Ru(PR3)2X] efficiently catalyze the cyclopropanation of styrene and other electron-rich alkenes in the presence of ethyl diazoacetate with a high cis stereoselectivity. When diphenyldiazomethane is employed as carbene source, the reaction with styrene, catalyzed by 1, affords mainly 1,1,3-triphenylpropene, as result of a formal :CPh2−:CHCH2Ph coupling. Furthermore, appreciable amounts of the metathesis and cyclopropanation products 1,1-diphenylethene and 1,2-diphenylcyclopropanes in a 1:1 molar ratio are observed. The carbene complex [(η5-C5H5)Ru(CPh2)(PPh3)Cl] (13), which was detected during the catalytic process, can be readily obtained in 85% isolated yield from 1 and diphenyldiazomethane in a one-pot reaction. With styrene, complex 13 undergoes a stoichiometric carbene transfer reaction, yielding the same organic products observed in the catalytic process with 1.
‘the last post?’: assessment of the failing post-retained crown (2014)

Failure of a post-retained restoration can provide a challenge to the general dental practitioner (GDP) in terms of diagnosis, treatment planning and communication with the patient. The cause of failure must be identified, and a thorough assessment of the restoration, remaining tooth and its functional and aesthetic demands carried out in order to plan treatment to provide the most reliable result. Clinical Relevance: This article discusses the assessment of failing post-retained crowns, with discussion of reasons for failure, thereby assisting the GDP in decision-making and treatment planning for such teeth.
Bone marrow cellularity at day 14 is the most important predictive factor for response in patients with AML who require double‐induction chemotherapy: Analysis from a large, single institution experience (2016)

In patients with acute myeloid leukemia (AML), the presence of residual disease at day 14 after primary induction therapy warrants consideration of a second induction cycle. However, data to guide retreatment decisions in such patients are presently limited. Here, we retrospectively reviewed data from 176 patients with AML treated at our institution with a second induction chemotherapy regimen because of day 14 residual disease. Clinical variables and nadir bone marrow features were assessed for correlations with complete remission (CR) and overall survival (OS). In our patient group, 59% achieved CR after a second induction course. Median OS for the entire group was 12.40 months (95% CI, 9.90-14.90) but 19.07 months (95% CI, 13.13-25.01) for those who attained a CR. Nadir marrow hypocellularity (P < 0.001) at day 14, absolute blast reduction of >50% (P = 0.030), and de novo disease status (P = 0.018) were significantly correlated with CR achievement after re-induction. Marrow hypocellularity at day 14 was the most significant predictor of CR on multivariate analysis (P < 0.001). Nadir marrow features did not independently correlate with OS when accounting for CR status. Re-induction was successful in achieving CR in most patients. Study patients who did not achieve CR were more likely to have nonhypocellular marrows.
Multiaccess Interference Reduction in OSTBC-MIMO Systems by Adaptive Projected Subgradient Method (2007)

We introduce adaptive linear filters based on the adaptive projected subgradient method that are suitable for online implementation of multiple access interference (MAI) suppression in OSTBC-MIMO systems. The proposed adaptive filters track the optimal solution of a new cost function that is robust against channel state information (CSI) mismatch. The adaptive update algorithm is based on projections onto closed convex sets that contain the optimal solution with high probability. The main features of the adaptive filters are that no matrix inversion of a sample covariance matrix is required and that a low-complexity recursive implementation is possible. Convergence analysis and simulation results show the effectiveness of the proposed schemes.
Theoretical and experimental research on pressing process of porous bodies made of MR wire material (2020)

Abstract The article represents the main principles of the theory of pressing process of products made of MR fiber material. It is showed that the equations of ideal (excluding external frictional force) pressing process of products made of MR material are represented as power function of pressing pressure depends on density of porous body. The power function of the hardening of the wire material in compact is determined. It is established that the ideal pressing process contains two stages in the range of relative densities of porous bodies [0.15; 0.7]. The main equation of pressing process of products made of MR is obtained. Experimental proof of hypotheses and assumptions confirmed their validity.
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer (2018)

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Activation of the reticulum endoplasmic stress response resulting in reduced protein synthesis was involved in IPI-9119-mediated inhibition of the AR pathway. In vivo, IPI-9119 reduced growth of AR-V7-driven CRPC xenografts and human mCRPC-derived organoids and enhanced the efficacy of enzalutamide in CRPC cells. In human mCRPC, both FASN and AR-FL were detected in 87% of metastases. AR-V7 was found in 39% of bone metastases and consistently coexpressed with FASN. In patients treated with enzalutamide and/or abiraterone FASN/AR-V7 double-positive metastases were found in 77% of cases. These findings provide a compelling rationale for the use of FASN inhibitors in mCRPCs, including those overexpressing AR-V7.
A Context Free TAG Variant (2013)

We propose a new variant of Tree-Adjoining Grammar that allows adjunction of full wrapping trees but still bears only context-free expressivity. We provide a transformation to context-free form, and a further reduction in probabilistic model size through factorization and pooling of parameters. This collapsed context-free form is used to implement efficient grammar estimation and parsing algorithms. We perform parsing experiments the Penn Treebank and draw comparisons to Tree-Substitution Grammars and between different variations in probabilistic model design. Examination of the most probable derivations reveals examples of the linguistically relevant structure that our variant makes possible. 1
Oxygen reduction at ``electrocoated`` Nafion-modified Ni-carbon composite electrodes in alkaline solution: The effect of temperature (1994)

The development of high surface area, high conductivity Ni-Carbon composite electrode structures for use in the oxygen reduction reaction (ORR) in alkaline solution is described. The improvement in the ORR kinetics at composite electrodes modified with electrocoated Nafion membranes and low Pt catalyst loadings was examined as a function of temperature. The electrocoated Nafion membranes appear to possess a higher degree of interfacial contact with the electrode surface and contain less defects than do conventionally dip coated films. The electrocoating procedure may offer a way to more uniformly coat high surface area, 3-D, electrode structures. The results presented indicate that the composite electrodes prepared with nickel overlayers (12 {mu}m diam. fibers), which possess high void volume, and lower Nafion loadings are not structurally stable during extensive potential cycling and gas evolution due to significant carbon loss. More structurally stable electrodes were prepared using nickel overlayers (4 {mu}m diam. fibers), with lower void volume, and higher Nafion loadings. The higher Nafion loadings, while assisting in the carbon retention also result in increased mass transport resistance. In addition, it was observed that the interior of the composite electrode was not uniformly coated with the polymer when using the smaller nickel fiber overlayer.more » The electrochemical studies of the structurally stable composite electrodes modified with Nafion and low Pt loadings indicate that the electrodes are useful catalyst supports providing intimate contact between the catalyst particles and the interfacial reaction zone.« less
ORNL material is in new cookware, more upcoming products (2018)

Researchers at Oak Ridge National Laboratory have come up with a material that could change the way you cook.
Protein acetylation and aging (2011)

Our results suggest the possible benefit of manipulating an intrinsic aging pathway that is independent of nutrition availability, a potential therapeutic route that might be able to bypass shortcomings of calorie restriction.
Crista Supinatoris Fractures of the Proximal Part of the Ulna (2015)

We recently conducted a retrospective review of the outcomes of twelve patients with a fracture of the crista supinatoris.IndicationsContraindicationsPitfalls & Challenges.
User localization using ultrasonic presence sensing systems (2012)

We consider an ultrasonic sensor system deployed for indoor presence detection. In such a presence sensing system, we are interested in the problem of user localization using time-difference-of-arrival (TDOA) measurements collected, due to transmission from sensors in different time slots, at a particular sensor. We present a tracking algorithm to improve estimation of TDOA values resulting from a user movement. Subsequently the localization algorithm to obtain user position from the estimated TDOA values is described. Validation of the algorithms is done using an experimental setup to demonstrate proof-of-concept in an office setup.
Methods for cellobiosan utilization (2023)

Disclosed herein are enzymes useful for the degradation of cellobiosan in materials such a pyrolysis oils. Methods of degrading cellobiosan using enzymes or organisms expressing the same are also disclosed.
Investigating acute effects of oncolytic virus infection of tumours (2009)

Oncolytic viruses (OVs) are selected or designed to eliminate malignancies by direct infection and lysis of cancer cells. In contrast to this concept of direct tumour lysis by viral infection, a significant portion of the in vivo tumour killing activity of two OVs, vesicular stomatitis virus (VSV) and vaccinia virus is caused by indirect killing of uninfected tumour cells. Limited virus infection rapidly triggers a loss of tumour perfusion within the tumour core. Tumour cells within the tumour rim remain viable and are associated with intact vasculature. Transcript profiling of tumours demonstrates a pro-inflammatory gene signature with significant induction of neutrophil chemo-attractants. Depletion of neutrophils in animals prior to VSV administration eliminates uninfected tumour cell apoptosis and permits more extensive replication and spreading of the virus throughout the tumour. Tumour targeted inflammation triggers extensive intravascular coagulation which is responsible for the loss of perfusion as inhibition of coagulation results in maintenance of tumour perfusion in the context of VSV therapy. Interestingly, the remaining viable tumour rim does not expand in tumours implanted into immune competent mice. Conversely, a massive expansion of the viable tumour rim ensues following treatment of tumour bearing nude mice that possess a defective adaptive T cell response. These results suggest that outgrowth of viable tumour cells from the tumour rim following OV therapy is inhibited by an adaptive immune response triggered to target tumour cells. Taken all together, these results indicate that targeted recruitment of neutrophils triggers coagulation within infected tumour beds and enhances the killing of malignant cells. Activation of inflammatory cells may be used for enhancing the effectiveness of oncolytic virus therapeutics as well as other anticancer agents that may similarly trigger inflammation. Understanding mechanism and consequences of inflammation dependent tumour cell death is important as loss of tumour perfusion has now also been measured in patients treated with vaccinia virus.
System‐Level EOS Issues for Analog Design (2014)

This chapter will discuss the system-level issues associated with electrical overstress (EOS) in chips, printed circuit boards (PCB), and systems. EOS protection device classifications, symbols, and types for both overvoltage and overcurrent conditions will be highlighted. System-level and system-like testing methods, such as IEC 61000-4-2, IEC 61000-4-5, and human metal model (HMM) waveforms and methods, will be reviewed. Examples of PCB design for digital-to-analog systems will also be provided.
[1]Rotaxanes and Pretzelanes: Synthesis, Chirality, and Absolute Configuration (2000)

The synthesis of aliphatically bridged [1](n)rotaxanes and (n)pretzelanes in preparative yields and the dependency of their chiroptical properties on the length (n) of their bridge are reported. A cycloenantiomeric bis(sulphonamide)[2]rotaxane with a sulphonamide group in its axle and its wheel was intramolecularly dialkylated by homologous bifunctional oligomethylene reagents to form chiral [1](n)rotaxanes bearing bridges of different lengths (n) between the axle and the wheel. Intramolecular dialkylation by 1,omega-dibromoalkanes of a topologically chiral bis(sulphonamide)[2]catenane with a sulphonamide group in both of the macrolactam rings leads to pretzel shaped molecules ((n)pretzelanes) with homologous bridges between the two macrocycles. Their yields decrease with decreasing length of the bridge. The shortest bridge isolated so far in reasonable amounts consists of six methylene groups ((6)pretzelane). Remarkably, a covalent connection of axle and wheel in a [2]rotaxane was successful even with much shorter bridges-down to only three methylene groups ([1](3)rotaxane). The structural changes of the [1](n)rotaxanes with decreasing bridge length is expressed by an increasing high-field shift in the 1H NMR spectra. Enantiomeric resolution of the racemates of both series was achieved in seven cases for the [1](n)rotaxanes and two for the (n)pretzelanes by use of chiral HPLC columns. The circular dichrograms of both compound families show a strong dependency on the length of the bridge. However, the shortest bridges displayed some additional unexpected deviations. A new specification of the absolute configuration of supramolecules, such as [n]catenanes, [n]rotaxanes and (n)pretzelanes is introduced together with some nomenclature additions.