gebhart/patrepeval huggingface dataset:
Peptide‐bond modification for metal coordination: Peptides containing two hydroxamate groups (2003)

Peptide-bond modification via N-hydroxylation has been explored as a strategy for metal coordination to induce conformational rigidity and orient side chains for specific molecular recognition. N-Hydroxyamides were prepared by reacting N-benzyloxyamino acid esters or amides with Fmoc-AA-Cl/AgCN (Fmoc: 9-fluorenylmethoxycarbonyl; AA: amino acid) in toluene or Fmoc-AA/HATU/DIEA in DMF (HATU: O-(7-azabenzotriazol-lyl)-1,1,3,3-tetramethyluronium hexafluorophosphate; DIEA: N,N-diisopropylethylamine; DMF: N,N-dimethylformamide), followed by deblocking of benzyl protecting groups. Novel linear and cyclic N,N'-dihydroxypeptides were efficiently assembled using Fmoc chemistry in solution and/or on a solid support. As screened by electrospray ionization-mass spectroscopy (ESI-MS), high iron-binding selectivity and affinity were attainable. Compounds having a spacer of two alpha-amino acids between the amino acids bearing the two hydroxamates, i.e., a spacer of 8 atoms, generated 1:1 iron complex species in the gas phase. Moreover, high performance liquid chromatography (HPLC), uv/vis, and (1)H-NMR analyses provided direct evidence for complex formations in solution. Significantly, the representative compound cyclo(Leu-Psi[CON(OH)]-Phe-Ala-Pro)(2) (P8) may serve as a robust metal-binding scaffold in construction of a metal-binding library for versatile metal-mediated molecular recognition.
VIS-SWIR wideband lens-free imaging (2021)

Lens-free imaging (LFI) has become an important microscopy tool in many life science and industrial applications. Due to the absence of optical lenses (such as objectives) and accompanying lens aberrations (such as chromatic aberrations), the LFI modality is well suited for optical inspection of microscopic objects in a wide spectral range. However, the relatively restricted spectral sensitivity of CMOS imagers, i.e. from visible (~400 nm) up to near-infrared range (~900 nm), limits the wide spectral use of the technique. Many microscopic samples contain valuable information both in the visible and in the short wave infra-red (SWIR), sometimes in addition to visible (VIS) and near-infrared (NIR). With the recent emergence of cost-effective image sensor technologies such as quantum-dot and graphene-based image sensors with high quantum efficiency in SWIR, new lens-free imaging opportunities are emerging for wideband and high throughput microscopy. We demonstrate for the first time an LFI system based on a quantum-dot image sensor, capable of operating in both the visible and short-wave infrared range. The holograms of the samples are obtained through multiple partially coherent illumination sources in both visible and short-wave infrared (ranging from 405 nm to 1550 nm). The captured holograms are reconstructed to obtain images of the sample in focus. We demonstrate an optical resolution of 3.48 micron in a field of view of 9.6 mm<sup>2</sup> over the whole spectral range. Our technique mitigates the need for bulky and expensive achromatic imaging optics and offers significant improvements in cost, field-of-view, scalability, and optical resolution to achieve microscopic imaging in both the visible and short-wave infrared spectral range with a simple imaging system. We present in this paper a performance analysis of the system and several potential applications and use cases.
A Polydiacetylene Microchip Based on a Biotin–Streptavidin Interaction for the Diagnosis of Pathogen Infections (2008)

A micropatterned polydiacetylene (PDA) chip, utilizing the unique fluorogenic property of PDA and a specific biotin-streptavidin (STA) interaction, is constructed to detect pathogen infections. To construct the PDA chip, biotin-modified diacetylene liposomes are immobilized on aldehyde glass and conjugated with STA, followed by UV irradiation to polymerize the STA-functionalized diacetylene liposomes. Genomic DNA of a model pathogen, Chlamydia trachomatis, is isolated from human samples and biotin-labeled target DNA is obtained through PCR amplification using biotin-11-dUTP. Owing to the stimulus caused by the biotin-STA interaction, the biotinylated DNA induces an intense fluorescence signal on the immobilized PDA. By using this strategy, it is possible to diagnose Chlamydia infections by applying DNA samples from several nonhealthy humans to a single PDA chip. The results of this study serve as the basis for a new strategy for fluorogenic PDA microarray-based diagnosis of pathogen infections.
ChemInform Abstract: Fine Tuning of Physico‐Chemical Parameters to Optimize a New Series of Novobiocin Analogues. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A unified analytical model for the carrier dynamics in trench insulated gate bipolar transistors (TIGBT) (2002)

A physically-based analytical model for the on-state carrier dynamics in Trench Insulated Gate Bipolar Transistors (TIGBT) is proposed. The model accounts for the enhanced carrier modulation in the drift base due to the PIN diode effect. The on-state phenomena in the TIGBT are accurately described using numerical simulations and analytical modeling. The PIN diode effect has a very important role in reducing the on-state forward voltage with virtually no compromise in the turn-off performance. It is concluded that the TIGBT is the most promising power structure in the area of high voltage or/and fast switching devices.
Predicting distributed retinal source activity from ERG data. II. Multiple stimulus approach (1988)

For pt.I see ibid., vol.35, no.11, p.941-7 (1988). The objective of this research is the noninvasive prediction of retinal cell activity; more specifically, the goal is to assess the healthiness of discrete regions of the retina. The authors describe a multiple-stimulus approach which involves a single-potential measurement of the cornea as is commonly done clinically at present, but which multiple-flash stimuli. The technique is ultimately dependent on the patient's ability to focus on the external flash stimulus pattern. The individual components of the ERG (electroretinogram), which are directly associated with specific parts of the stimulus pattern (and thus, localized regions on the retina), are stripped off of the composite ERG using signal-correlation techniques. At the heart of this approach is the requirement that the isolated stimuli are each individually uncorrelated to one another, i.e., they are random in time. An analytical ERG is constructed to test the efficacy of the use of single- and double-kernel correlations for predicting retinal impulse responses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interconvertible Four-, Five-, and Six-Coordinate Cobalt Complexes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterconvertible Four-, Five-, and Six-Coordinate Cobalt ComplexesC. H. Langford, E. Billig, S. I. Shupack, and Harry B. GrayCite this: J. Am. Chem. Soc. 1964, 86, 14, 2958–2959Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/ja01068a055https://doi.org/10.1021/ja01068a055research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radioimmunotherapy for the intensification of conditioning before stem cell transplantation: differences in dosimetry and biokinetics of 188Re- and 99mTc-labeled anti-NCA-95 MAbs. (2000)

Myeloablative radiation absorbed doses can easily be achieved using 188Re-MAb. 99mTc- and 188Re-MAb showed similar whole-body distributions. However, direct prediction of radiation absorbed doses from the 99mTc-MAb, assuming identical biokinetic behavior, is not valid for the 188Re-MAb in a single patient. Therefore, individual dosimetry using 188Re-MAb is needed to calculate therapeutic activity.
On Protective Buffer Policies (1993)

This paper (see [1] for details) is concerned with the study of buffering policies that arise in the context of fast packet-switched networks carrying different classes of traffic. These networks are faced with the difficult task of satisfying the needs of connections requiring dif­ ferent Qualities Of Service (QOS), but sharing the same physical resources, e.g., bandwidth and buffers. Here, we focus on space priority disciplines, which provide different loss priorities to packets as a function of their service class.
Correction to “Tandem Facial Amphiphiles for Membrane Protein Stabilization” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "Tandem Facial Amphiphiles for Membrane Protein Stabilization"Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J. W. Miercke, Søren G. F. Rasmussen, Rebecca A. Robbins, Rohini R. Rana, Claus J. Loland, Brian Kobilka*, Robert Stroud*, Bernadette Byrne*, Ulrik Gether*, and Samuel H. Gellman*Cite this: J. Am. Chem. Soc. 2013, 135, 34, 12922Publication Date (Web):August 13, 2013Publication History Published online13 August 2013Published inissue 28 August 2013https://pubs.acs.org/doi/10.1021/ja407245mhttps://doi.org/10.1021/ja407245mcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views824Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (426 KB) Get e-Alertsclose Get e-Alerts
On pathloss models for adjacent-channel interference in cognitive whitespace systems (2016)

Adjacent channel interference is one of the fundamental processes limiting wireless system performance. In particular, cognitive radio exploiting “whitespace,” i.e., spectral guard bands between existing services, are limited by adjacent channel interference to victim receivers. Upper-bounding such interference requires accurate knowledge of minimum pathloss at short range (less than a few hundred meters), but existing, standardized models focus on maximum pathloss at long range. This paper discusses methods to characterize more accurately the low pathloss regime. These improved models account for variations of the pathloss exponents, the random nature of the occurrence of line-of-sight, and the distance dependence of fading parameters. By comparing standard models to ray tracing results, we demonstrate the large impact that such modeling considerations can have on outage probability in cognitive systems.
Photocatalytic Activity of NaNbO3 Thin Films (2009)

NaNbO(3) thin films prepared by the sol-gel method had homogeneous microstructure with an average grain size of 15-25 nm and exhibited photoinduced hydrophilic conversion under UV irradiation. However, the films had little photocatalytic oxidation activity under UV irradiation. This is the first observation that NaNbO(3) undergoes photoinduced hydrophilicity under UV irradiation.
Photoinitiated electron transfer-substitution reaction of diphenyl ketyl with protonated 4-cyanopyridine (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoinitiated electron transfer-substitution reaction of diphenyl ketyl with protonated 4-cyanopyridineBruno M. Vittimberga, Francesco Minisci, and Sergio MorrocchiCite this: J. Am. Chem. Soc. 1975, 97, 15, 4397–4398Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/ja00848a044https://doi.org/10.1021/ja00848a044research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data assignment and access scheduling exploration for multi-layer memory architectures (2004)

This work presents an exploration framework which performs data assignment and access scheduling exploration for applications given a multilayer memory architecture. Our framework uses multiobjective criteria during exploration, such as application execution time, energy, bandwidth, and data size. In order to tackle the complexity of the exploration, it is divided into three phases; Pareto diagram composition, data assignment, and access scheduling. The first phase produces multidimensional Pareto points for our application. After this phase, our framework produces distinct data assignments which are represented as Pareto points in a two dimensional space defined by bandwidth requirements and size requirements. Finally, the scheduling phase finds possibly optimal order of the tasks and performs precise scheduling of the tasks. Three feedbacks paths are present which can be used to iteratively improve exploration results. It is possible to trade off the quality of the results and the algorithm runtime. We have evaluated our framework on a medical image processing application. We have shown that our algorithms can perform exploration of the huge design space in an iterative manner and obtains good Pareto diagram coverage.
A review of parametric resonance in microelectromechanical systems (2013)

Many applications of microelectromechanical systems utilize mechanical vibratory motion. A number of interesting dynamical effects occur in these minimally damped, precisely manufactured devices. These effects can be caused by the structural mechanics, the actuation mechanism, or both. One such phenomenon, parametric resonance, occurs when displacement-dependent forcing is present in the microsystem. This paper reviews the key dynamic effects, and summarizes some of the development of devices that utilize parametric resonance or parametric amplification. In addition, signal-to-noise issues are discussed with respect to the ultimate sensitivity of mass sensors that use parametric resonance, and strategies for obtaining the highest sensitivity are presented. Here the authors describe parametric resonance phenomenon as a dynamical system, review its experimental observation in microsystems, and conclude by discussing the various applications.
Efficacy of Tat-Conjugated Ritonavir-Loaded Nanoparticles in Reducing HIV-1 Replication in Monocyte-Derived Macrophages and Cytocompatibility with Macrophages and Human Neurons (2010)

Human immunodeficiency virus (HIV)-1 targets mononuclear phagocytes (MP), which disseminate infection to organs such as brain, spleen and lymph. Thus MP, which include microglia, tissue macrophages and infiltrating monocyte-derived macrophages (MDM), are important target of anti-HIV-1 drug therapy. Most of the currently used antiretroviral drugs are effective in reducing viral loadin the periphery but cannot effectively eradicate infection from tissue reservoirs such as brain MP. HIV-1 infection of the central nervous system can lead to a wide variety of HIV-1-associated neurocognitive disorders. In this study, we demonstrate that ritonavir-loaded nanoparticles (RNPs) are effective in inhibiting HIV-1 infection of MDM. Reduced infection is observed in multiple read-out systems including reduction of cytopathic effects, HIV-1 p24 protein secretion and production of progeny virions. Furthermore, the RNPs retained antiretroviral efficacy after being removed from MDM cultures. As HIV-1-infected cells in the brain are likely to survive for a long period of time, both acute and chronic infection paradigms were evaluated. Tat-peptide-conjugated RNPs (Tat-RNP) were effective in both short-term and long-term HIV-1-infected MDM. Importantly, we confirm that delivery of RNPs, both with and without Tat-peptide conjugation, is toxic neither to MDM nor to neural cells, which may be bystander targets of the nanoformulations. In conclusion, Tat-NPs could be a safe and effective way of delivering anti-HIV-1 drugs for controlling viral replication occurring within brain MP.
An experimental investigation of the influence of an electrostatic potential on electron mass as predicted by Weber's force law (2004)

Assis (J. Phys. Soc. Jpn.} 62, 1418 (1993.) showed that Weber's force law between moving charges leads to the conclusion that the inertial mass of an electron depends on the charges that surround it. The experimental confirmation of this effect was claimed by Mikhailov (Annal. Fond. Louis de Broglie, 24, 161 (1999).) who detected frequency changes of a glow discharge lamp oscillator as a function of the voltage applied to the shield surrounding the oscillator. We carefully repeated the experiment employing an optical rather than the electrical coupling, used by Mikhailov, to measure the oscillator frequency as a function of shield voltage. Our results did not show any frequency changes associated with the change in shield voltage that could be interpreted as a change in the electron mass induced by the surrounding charges. As this effect is an inescapable consequence of Weber's force law, our experiment strongly indicates that this force law is not valid.PACS No.: 41.20.q
Synthesis of 2,3‐dihydro‐5H‐oxazolo[2,3‐B]quinazolin‐5‐ones (1979)

Abstract Iodide‐catalyzed ring expansion of 2‐[(1‐aziridinylcarbonyl)amino]benzoic acid methyl ester (2) gave 2,3‐dihydro‐5 H ‐oxazolo[2,3‐ b ]quinazolin‐5‐one (3) in quantitative yield. Treatment of the dimethyl analog of 2 (9) with sodium iodide in acetone gave a mixture of the 2,3‐dihydro‐2,2‐dimethyl‐ (10) and 2,3‐dihydro‐3,3‐dimethyl‐5 H ‐oxazolo[2,3‐ b ]quinazolin‐5‐ones (11). However, rearrangement of 9 with sulfuric acid produced only 10. Synthesis of 11 by another route for comparison is described, and the known syntheses of 2,3‐dihydro‐5 H ‐oxazolo[2,3‐ b ]quinazolin‐5‐ones are reviewed.
A Kinetic Model for Glucose Levels and Hemoglobin A1c Provides a Novel Tool for Individualized Diabetes Management (2020)

Our kinetic model offers mechanistic insights into the relationship between glucose levels and glycated hemoglobin. Therefore, the new glycemic marker does not only accurately reflect laboratory HbA1c but also provides novel concepts to explain the mechanisms for the mismatch between HbA1c and average glucose in some individuals, which has implications for future clinical management.
ElectroRing: Subtle Pinch and Touch Detection with a Ring (2021)

We present ElectroRing, a wearable ring-based input device that reliably detects both onset and release of a subtle finger pinch, and more generally, contact of the fingertip with the user’s skin. ElectroRing addresses a common problem in ubiquitous touch interfaces, where subtle touch gestures with little movement or force are not detected by a wearable camera or IMU. ElectroRing’s active electrical sensing approach provides a step-function-like change in the raw signal, for both touch and release events, which can be easily detected using only basic signal processing techniques. Notably, ElectroRing requires no second point of instrumentation, but only the ring itself, which sets it apart from existing electrical touch detection methods. We built three demo applications to highlight the effectiveness of our approach when combined with a simple IMU-based 2D tracking system.