gebhart/patrepeval huggingface dataset:
Virological surveillance of human influenza in Indonesia, October 2008-March 2010 (2011)

Despite the high prevalence of highly pathogenic H5N1 influenza A viruses in Indonesia, epidemiology information on seasonal human influenza is lacking. The present authors, therefore, conducted virologic surveillance in Surabaya, East Java from October 2008 to March 2010. Influenza viruses, including pandemic (H1N1) 2009 viruses, were isolated from 71 of 635 individuals tested. Seasonal influenza peaked in the rainy season. Compared with seasonal influenza viruses, pandemic 2009 viruses were isolated from younger patients with milder symptoms. Given the high prevalence of H5N1 infections in humans, continued influenza surveillance is essential for pandemic preparedness.
Methods of Evaluating the Utility of Continuous Glucose Monitor Alerts (2010)

Continuous glucose monitor alerts are capable of both detecting and predicting low and high BG events. The setting of alerts entails a trade-off between predictive ability and FA rate. Realistic analysis of this trade-off will guide patients in the effective utilization of CGM.
Shift-Sliding and Depth-Pop for 3D Positioning (2016)

We introduce two new 3D positioning methods. The techniques enable rapid, yet easy-to-use positioning of objects in 3D scenes. With SHIFT-Sliding, the user can override the default assumption of contact and non-collision for sliding, and lift objects into the air or make them collide with other objects. DEPTH-POP maps mouse wheel actions to all object positions along the mouse ray, where the object meets the default assumptions for sliding. We will demonstrate the two methods in a desktop environment with the mouse and keyboard as interaction devices. Both methods use frame buffer techniques for efficiency.
Characterization of DNA Optical Microfiber Devices Fabricated by Drawing (2011)

We demonstrate the characterization of DNA optical microfiber devices fabricated by manually drawing. The strength, flexibility and optical loss are experimentally investigated. DNA optical microfiber devices are expected to be used as optical biosensors.
COAXIAL TURBULENT JET MIXER FOR CONTROLLED SYNTHESIS OF NANOPARTICLES (2013)

Development of methods for high-throughput production of nanoparticles (NPs) in a reproducible and controlled manner is important for the translation of NPs to the clinic. We report a simple and versatile coaxial turbulent jet mixer platform for high-throughput preparation of various functional NPs in a reproducible and controllable manner. With a production rate sufficiently high for in vivo studies, clinical trials, and industrial scale production, this approach has the potential to improve the homogeneity and provide better quality control in the translation of nanomedicines to the clinic.
Uptake of Pyocin S3 Occurs through the Outer Membrane Ferripyoverdine Type II Receptor of Pseudomonas aeruginosa (1999)

Pyocin S3 was found to kill exclusively Pseudomonas aeruginosa isolates producing type II pyoverdine (exemplified by strain ATCC 27853). Killing was specifically inhibited by addition of type II ferripyoverdine. All Tn5 mutants resistant to pyocin S3 were defective for pyoverdine-mediated iron uptake and failed to produce an 85-kDa iron-repressed outer membrane protein. We conclude that this protein is probably the type II ferripyoverdine receptor that is used by pyocin S3 to gain entry into the cell.
Search for long-lived charged particles in proton-proton collisions ats=13  TeV (2016)

Results are presented of a search for heavy stable charged particles produced in proton-proton collisions at $\sqrt{s}=13\text{ }\text{ }\mathrm{TeV}$ using a data sample corresponding to an integrated luminosity of $2.5\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ collected in 2015 with the CMS detector at the CERN LHC. The search is conducted using signatures of anomalously high energy deposits in the silicon tracker and long time-of-flight measurements by the muon system. The data are consistent with the expected background, and upper limits are set on the cross sections for production of long-lived gluinos, top squarks, tau sleptons, and leptonlike long-lived fermions. These upper limits are equivalently expressed as lower limits on the masses of new states; the limits for gluinos, ranging up to 1610 GeV, are the most stringent to date. Limits on the cross sections for direct pair production of long-lived tau sleptons are also determined.
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes (2021)

Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patients and healthy controls. BD astrocytes showed changes in transcriptome and induced a reduction in neuronal activity when co-cultured with neurons. IL-1β-stimulated BD astrocytes displayed a unique inflammatory gene expression signature and increased secretion of IL-6. Conditioned medium from stimulated BD astrocytes reduced neuronal activity, and this effect was partially blocked by IL-6 inactivating antibody. Our results suggest that BD astrocytes are functionally less supportive of neuronal excitability and this effect is partially mediated by IL-6. We confirmed higher IL-6 in blood in a distinct cohort of BD patients, highlighting the potential role of astrocyte-mediated inflammatory signaling in BD neuropathology.
Regenerative feedback repeaters for programmable interconnections (2002)

FPGA performance is limited mainly by the delay of the programmable interconnection network. This delay increases quadratically with the number of series switches, and is a problem especially when the programmable switches are implemented using MOS transistors, since these have an appreciable resistance and capacitance. The delay can be reduced, at the cost of routability, by limiting the number of series switches per interconnection, or at the cost of area by inserting repeaters. Conventional bidirectional repeaters consist of sets of unidirectional tristate buffers and memory cells. Their benefit is limited due to high area and delay penalty. Area and delay penalty can be alleviated by using a regenerative feedback that senses the beginning of a transition and subsequently enforces it. This requires one buffer and no memory cells. This article shows a network with such repeaters for direction-independent buffering.
HomePlug green PHY for the LVDC PLC concept: Applicability study (2015)

It has been shown that high-frequency (HF) band power line communication (PLC), that is, the HomePlug 1.0 specification, is feasible for a low-voltage direct current (LVDC) smart grid (SG) system, where power electronics and low-voltage DC are applied to the electricity distribution. In this paper, the applicability of the latest HomePlug specification, Green PHY (GP), is studied within the LVDC PLC concept. Channel characteristics between 2-30 MHz in the HomePlug GP frequency band and noise in the channel from the terminals of the PLC couplers are measured. Furthermore, data transmission tests with HomePlug GP compliant modems are carried out in the LVDC laboratory setup and on the LVDC research site.
SITC 2018 workshop report: Immuno-Oncology Biomarkers: State of the Art (2018)

Identification of biomarkers in cancer immunotherapy that predict therapeutic response and/or limit adverse events are a critical need in the field. To address recent progress and hurdles around cancer biomarker development and utilization, the Society for Immunotherapy of Cancer (SITC) convened a workshop, "Immuno-Oncology Biomarkers: State of the Art," on May 16-17, 2018. Topics discussed included challenges in handling biospecimens, identification and validation of new biomarkers, data sharing, and collaborating across disciplines to advance biomarker development. Panel discussions followed session presentations to help foster participant conversation and discuss future projects and collaborations. The results of the Workshop include the development of new initiatives for the SITC Biomarkers Committee.
A Proposal for Enhancing the Security and Privacy of Digital Currencies (2023)

Regarding digital currencies, the authors focus on 1) the security issues with the advent of quantum computers and 2) the privacy issues in relation with CBDC's wider collection of personal data. Many legal issues can be solved using technology. Thus, they propose central banks to adopt their privacy-enhancing technologies in cryptography, called “SK4SC,” which performs KYC (know your customer) while keeping PKI (public key infrastructure)-registered trading partners anonymous. Security and privacy in digital currency can be trade-offs. For example, the AML/CFT effort requires the collection of personal information about innocent people, which can be detrimental to their privacy. On the other hand, excessive restrictions on the collection of personal information to protect privacy may weaken the AML/CFT. However, adopting SK4SC can resolve the trade-offs by anonymizing KYC, which is essential for the AML/CFT.
In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas1 (2007)

Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid derivative, pivaloyloxymethyl butyrate (AN-9), for the treatment of gliomas. Relative to control and single-modality treatments, the combination of AN-9 and radiation significantly inhibited tumor growth and prolonged time to failure in mice bearing glioma xenografts. The enhanced response to radiation was accompanied by inhibition of cellular proliferation and by increased phosphorylation of H2AX, implicating DNA double-strand breaks in the antineoplastic effects of AN-9 and radiation. The data suggest that AN-9 in combination with radiation may be an effective therapy for malignant gliomas.
Achievement of the Japanese Society for Dialysis Therapy Guideline Targets for Mineral Metabolism Measures: One Japanese University Center Result (2007)

A consensus conference for the Guidelines for the Management of Secondary Hyperparathyroidism in Chronic Dialysis Patients was conducted in the general meeting of the Japanese Society for Dialysis Therapy (JSDT) in June 2006, and the guidelines were proposed in the Journal of JSDT in 4 months later. The aim of this study was performed on the status of observance with the data, based on 6 months later proposal of the guidelines. Only 48.9% stayed within the range specified by the calcium and phosphorus guideline. Moreover, only 12% of patients were able to remain within the ranges specified by all three guidelines (calcium, phosphorus, and PTH), 6 months later proposal of the guidelines. In our institution, compliance with the JSDT guidelines was inadequate. Major reasons were the special characteristics of the medical care system and patients in our institution as a university hospital. Further improvement in the contents and method of the use of the guidelines is necessary alongside observation of the present situation in Japan.
Evaluierung von 3D-Rekonstruktionsverfahren in der Stereo-Laparoskopie. (2016)

S.58-63
The variance of quantitative estimates in shear wave imaging: Theory and experiments (2012)

In this paper, we investigate the relationship between the estimated shear modulus produced in shear wave imaging and the acquisition parameters. Using the framework of estimation theory and the Cramer-Rao lower bound applied both to the estimation of the velocity field variance and to the estimation of the shear wave travel time, we can derive the analytical formulation of the shear modulus variance σ(2)(μ) using relevant physical parameters such as the shear wave frequency, bandwidth, and ultrasonic parameters. This variance corresponds to the reproducibility of shear modulus reconstruction for a deterministic, quasi-homogeneous, and purely elastic medium. We thus consider the shear wave propagation as a deterministic process which is then corrupted during its observation by electronic noise and speckle decorrelation caused by shearing. A good correlation was found between analytical, numerical, and experimental results, which indicates that this formulation is well suited to understand the parameters' influence in those cases. The analytical formula stresses the importance of high-frequency and wideband shear waves for good estimation. Stiffer media are more difficult to assess reliably with identical acquisition signal-to-noise ratios, and a tradeoff between the reconstruction resolution of the shear modulus maps and the shear modulus variance is demonstrated. We then propose to use this formulation as a physical ground for a pixel-based quality measure that could be helpful for improving the reconstruction of real-time shear modulus maps for clinical applications.
Identification of fluid overload in elderly patients with chronic kidney disease using bioimpedance techniques (2022)

Diagnosis of fluid overload (FO) in early stage is essential to manage fluid balance of patients with chronic kidney disease (CKD) and to prevent cardiovascular disease (CVD). However, the identification of fluid status in patients with CKD is largely dependent on the physician's clinical acumen. The ratio of fluid overload to extracellular volume (FO/ECV) has been used as a reference to assess fluid status. The primary aim of this study was to compare FO/ECV with other bioimpedance methods and clinical assessments in patients with CKD. Whole body ECV, intracellular volume (ICV), total body water (TBW), and calf normalized resistivity (CNR) were measured (Hydra 4200). Thresholds of FO utilizing CNR and ECV/TBW were derived by receiver operator characteristic (ROC) analysis based on data from pooled patients with CKD and healthy subjects (HSs). Clinical assessments of FO in patients with CKD were performed by nephrologists. Patients with CKD (stage 3 and stage 4) (<i>n</i> = 50) and HSs (<i>n</i> = 189) were studied. The thresholds of FO were ≤14.3 (10<sup>-2</sup> Ωm<sup>3</sup>/kg) for females and ≤13.1 (10<sup>-2</sup> Ωm<sup>3</sup>/kg) for males using CNR and ≥0.445 in females and ≥0.434 in males using ECV/TBW. FO was diagnosed in 78%, 62%, and 52% of patients with CKD by CNR, FO/ECV, and ECV/TBW, respectively, whereas only 24% of patients with CKD were diagnosed to be FO by clinical assessment. The proportion of FO in patients with nondialysis CKD was largely underestimated by clinical assessment compared with FO/ECV, CNR, and ECV/TBW. CNR and FO/ECV methods were more sensitive than ECV/TBW in identifying fluid overload in these patients with CKD.<b>NEW & NOTEWORTHY</b> We found that fluid overload (FO) in patients with nondialysis CKD was largely underestimated by clinical assessment compared with bioimpedance methods, which was majorly due to lack of appropriate techniques to assess FO. In addition, although degree of FO by bioimpedance markers positively correlated with the age in healthy subjects (HSs), no difference was observed in the three hydration markers between groups of 50 ≤ age <70 yr and age ≥70 yr in the patients with CKD.
Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models (2019)

The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.
Electrical Properties of Boron Nitride Matrix Composites: II, Dielectric Relaxations in Boron Nitride–Silicon Carbide Composites (2001)

A low‐frequency Maxwell–Wagner relaxation, resulting from space‐charge buildup, was observed when BN–SiC composites were subjected to an ac current. This paper discusses the Maxwell–Wagner relaxation and information that it reveals about the microstructure of the composite. A modified Maxwell–Wagner equation for the real part of the permittivity is used to model the data. SiC has a higher dielectric constant than that of BN. The microstructure of these composites is anisotropic, with BN platelets preferentially oriented perpendicular to the hot‐pressing direction. Samples measured in this direction exhibit a lower dielectric constant than those measured parallel to the hot‐pressing direction. In regard to frequency response, the permittivity of BN shows no dependence on frequency, whereas frequency dependence is seen with increasing SiC content.
Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD (2004)

Members of the tumor necrosis factor superfamily of receptors induce apoptosis by recruiting adaptor molecules through death domain interactions. The central adaptor molecule for these receptors is the death domain-containing protein Fas-associated death domain (FADD). FADD binds a death domain on a receptor or additional adaptor and recruits caspases to the activated receptor. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signals apoptosis through two receptors, DR4 and DR5. Although there is much interest in TRAIL, the mechanism by which FADD is recruited to the TRAIL receptors is not clear. Using a reverse two-hybrid system we previously identified mutations in the death effector domain of FADD that prevented binding to Fas/CD95. Here we show that these mutations also prevent binding to DR5. FADD-deficient Jurkat cells stably expressing these FADD mutations did not transduce TRAIL or Fas/CD95 signaling. Second site compensating mutations that restore binding to and signaling through Fas/CD95 and DR5 were also in the death effector domain. We conclude that in contrast to current models where the death domain of FADD functions independently of the death effector domain, the death effector domain of FADD comes into direct contact with both TRAIL and Fas/CD95 receptors.
Resonance and Selective Communication Via Bursts in Neurons Having Subthreshold Oscillations (2002)

Revealing the role of bursts of action potentials is an important step toward understanding how the neurons communicate. The dominant point of view is that bursts are needed to increase the reliability of communication between neurons (Lisman 1997). Here we present an alternative but complementary hypothesis. We consider the effect a short burst on a model postsynaptic cell having damped oscillation of its membrane potential. The oscillation frequency (eigenfrequency) plays a crucial role. Due to the subthreshold membrane resonance and frequency preference, the responses of such a cell are amplified when the intra-burst frequency equals the cell’s eigenfrequency. Responses are negligible, however, if the intra-burst frequency is twice the eigen-frequency. Thus, the same burst could be effective for one cell and ineffective for another depending on their eigenfrequencies. This theoretical observation suggests that, in addition to coping with unreliable synapses, bursts of action potentials may provide effective mechanisms for selective communication between neurons.
Interaction of cAMP Derivatives with the ‘Stable’ CAMP‐Binding Site in the CAMP‐Dependent Protein Kinase Type I (1982)

cAMP binding to the 'stable' cAMP-binding sites in the regulatory subunit of the cAMP-dependent protein kinase type I was investigated using a set of 18 selected derivatives. All the tested analogues were competitive with [3H]cAMP and inhibitor constants from 12 nM to 20 microM with the free regulatory subunit were determined. The cAMP molecule seemed to be bound by these specific hydrogen bonds to the 5' and 3' oxygen, the 2' hydroxyl, and an ion pair interaction between the negative charge in equatorial position and a positively charged amino acid side chain. The adenine base is rather unspecifically bound with no hydrogen bonds involved. This binding specificity of the 'stable' site is similar to the requirement for dissociation as determined by the activation of the kinase by a respective analogue. This indicates that occupation of the 'stable' sites leads to activation of the protein kinase. The presence of the catalytic subunit reduced the affinity of most analogues. The binding of one derivative with the negative charge fixed in the axial position is not influenced by the addition of the catalytic subunit and ATP. A plausible model for a conformational change during the activation process in the 'stable' site is discussed.
SEPARATE AND POLYMORPHIC LOCI CONTROLLING TWO TYPES OF POLYPEPTIDE CHAINS BEARING THE H‐2 PRIVATE AND PUBLIC SPECIFICITIES (1975)

SUMMARY Serological and genetic analyses of H‐2 antigens indicate that each K or D region allele controls two highly polymorphic antigenic sites, the alpha site corresponding to the private specificity and the gamma site corresponding to the long public specificities. Studies of cell surface distribution and biochemical characteristics of the alpha type specificity H‐2.4 and gamma type specificity H‐2.28 in the product of a D region allele, D d , demonstrate that these specificities are carried on two different polypeptide chains. Accordingly, two distinct and polymorphic genes are postulated to code for the product controlled by the D region of H‐2.
Profiling of low back pain patients for the design of a tailored coaching application (2022)

Low back pain is a major public health problem that is the leading cause of disability in most countries. The recommendations are to propose personalized physical activity programs according to the individual characteristics (motivation, preferences, attitude towards physical activity) of each patient. However, the current management of low back pain includes rehabilitation programs that are costly and/or not always personalized. The objective of this research is to better understand the characteristics of people with chronic low back pain to identify typical profiles to inform the design of a tailored coaching mobile application. We selected eight concepts and associated scales to characterize the population: general health status (MYMOP), treatment burden (TBQ), quality of life (EQ-5D-5L), level (IPAQ), fears and beliefs (FABQ-AP) and motivation (EMAPS) for physical activity, emotional state (PHQ-9) and feeling of self-efficacy (FC-CPSES). These questionnaires were administered online via an e-cohort of low back pain patients. 193 patients with chronic low back pain were included. A clustering analysis allowed us to distinguish 4 profiles: (1) “Unmotivated,” characterized by the lowest motivation and the highest amotivation toward physical activity (i.e., they do not understand why it is useful), (2) “Cautious” with low motivation and having the highest fears and beliefs toward physical activity, (3) “Depressed” with good intrinsic motivation but also a significant level of depressive symptoms, and (4) “Confident” also showing good intrinsic motivation and having the highest self-efficacy. These four profiles of patients will be used to design a coaching mobile application tailored along the priorities (e.g., physical activity, pain management) and types of motivational messages displayed on the tailored mobile application.
Cathodes for Lithium-Ion Batteries : Some Comparisons (1998)

Foilowing a review of quahty criteria for the design or a cathode inserdon host fora hthium-ion rechargeable batterycomparisons are made beIween layered and fework hosts having simple anion versus polyanionrraysThe elecIrhemical perfoance of the bIannerite Li1VMoO6is shown lo support a larger capacity(200mAhg)but a lower voltage(24V vs hthium)than the NASICON sysIem LilF2(SO4)2PO4(80mAhg at33V)at a currendensity of l mAcm2