gebhart/patrepeval huggingface dataset:
Properties of as welded and heat treated pure titanium–7075 Al–Zn–Mg alloy friction weld joints (2001)

The effects of joining conditions and an age hardening post­weld heat treatment (PWHT) at 120°C for 24 h on the tensile strength and metallurgical properties of dissimilar friction joints between pure titanium and age strengthened 7075 Al–Zn–Mg alloy were investigated. Highest strength was achieved using intermediate friction pressure (150 MPa), short friction time (0.5 s), and high upsetting (forging) pressure (400 MPa). The joint tensile strength decreased when the joint diameter was increased from 8 to 16 mm. The joint tensile strength of as welded (AW) dissimilar joints was similar to that of PWHT joints with diameters of 8, 12, and 16 mm. Detailed TEM confirmed that there was a negligible difference in the thickness of the intermetallic layer formed at the dissimilar joint interface for AW and PWHT joints. While the intermetallic phases formed at the joint interface comprised Al 3 Ti, τ (Ti 2 Mg 3 Al 18 ), and Al in AW joints, they consisted of Al+ τ or Mg 2 Al 3 + τ+Al in PWHT joints. Softened regions were generated in 7075 base material immediately next to the interface in AW joints. Post­weld heat treatment increased the hardness of the softened region almost to that of as received 7075–T6 base material in 12 and 16 mm diameter joints. In contrast, the hardness of the softened region in 8 mm diameter joints could not be recovered to that of the as received material. This was a result of overaging and coarse precipitates in the softened region produced during the friction welding operation.
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA (2009)

The POT1-TPP1 heterodimer, the major telomere-specific single-stranded DNA-binding protein in mammalian cells, protects chromosome ends and contributes to the regulation of telomerase. The recent discovery of telomeric RNA raises the question of how POT1 faithfully binds telomeric ssDNA and avoids illicit RNA binding that could result in its depletion from telomeres. Here we show through binding studies that a single deoxythymidine in a telomeric repeat dictates the DNA versus RNA discrimination by human POT1 and mouse POT1A. We solve the crystal structure of hPOT1 bound to DNA with a ribouridine in lieu of the critical deoxythymidine and show that this substitution results in burying the 2(')-hydroxyl group in a hydrophobic region (Phe62) of POT1 in addition to eliminating favorable hydrogen-bonding interactions at the POT1-nucleic acid interface. At amino acid 62, Phe discriminates against RNA binding and Tyr allows RNA binding. We further show that TPP1 greatly augments POT1's discrimination against RNA.
Strategies to Enhance Viral Penetration of Solid Tumors (2011)

The efficient delivery of viral vectors to tumors is an active area of investigation. A number of barriers exist that must be overcome to achieve good penetration of vectors into tumors and distribution of their effects throughout the tumor mass. Replicating oncolytic viruses have the advantage of being able to amplify the initial dose, but progeny virus are prevented from spreading because of a dense mass of tightly packed cells with a dense extracellular matrix, admixed normal stromal cells, and high interstitial pressure. Although intratumoral injection may ensure initial delivery the distribution achieved by intravenous administration may be superior and come with beneficial bystander damage to the tumor vasculature. Strategies to enhance intravenous delivery and subsequent spread of these vectors within tumors are being developed by a number of groups. Achieving the goal of efficient penetration and spread of viruses within solid tumors is a necessary prerequisite to significant improvements in virus-vectored therapy of solid tumors.
An Improved Ring‐Closing Metathesis Approach to Fluorinated and Trifluoromethylated Nitrogen Heterocycles. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Conceptual Framework for the Progression of Balance Exercises in Persons with Balance and Vestibular Disorders. (2015)

There is little information in peer-reviewed literature to specifically guide the choice of exercise for persons with balance and vestibular disorders. The purpose of this study is to provide a rationale for the establishment of a progression framework and propose a logical sequence in progressing balance exercises for persons with vestibular disorders. Our preliminary conceptual framework was developed by a multidisciplinary team of physical therapists and engineers with extensive experience with people with vestibular disorders. Balance exercises are grouped into six different categories: static standing, compliant surface, weight shifting, modified center of gravity, gait, and vestibulo-ocular reflex (VOR). Through a systematized literature review, interviews and focus group discussions with physical therapists and postural control experts, and pilot studies involving repeated trials of each exercise, exercise progressions for each category were developed and ranked in order of degree of difficulty. Clinical expertise and experience guided decision making for the exercise progressions. Hundreds of exercise combinations were discussed and research is ongoing to validate the hypothesized rankings. The six exercise categories can be incorporated into a balance training program and the framework for exercise progression can be used to guide less experienced practitioners in the development of a balance program. It may also assist clinicians and researchers to design, develop, and progress interventions within a treatment plan of care, or within clinical trials. A structured exercise framework has the potential to maximize postural control, decrease symptoms of dizziness/visual vertigo, and provide "rules" for exercise progression for persons with vestibular disorders. The conceptual framework may also be applicable to persons with other balance-related issues.
In vivo identification of morphologic retinal abnormalities in neuromyelitis optica (2013)

We have identified a pattern of retinal morphologic abnormalities in NMO that is associated with severe retinal axonal and neuronal loss and corresponding visual disability. MME may contribute to poor visual outcomes following NMO-associated ON or alternatively represent a marker of ON severity. Additionally, our results support that subclinical involvement of the anterior visual pathway may occur in NMO spectrum disorders.
Modulation of binocular rivalry with rapid monocular visual stimulation (2020)

Abstract Rapid visual stimulation can increase synaptic efficacy by repeated synaptic activation. This long-term potentiation-like (LTP-like) effect can induce increase human visual cortex excitability. To examine the effect of rapid visual stimulation on perception, we tested the hypothesis that rapid monocular visual stimulation would increase the dominance of the stimulated eye in a binocular rivalry task. Participants (n = 25) viewed orthogonal 0.5 cpd gratings presented in a dichoptic anaglyph to induce binocular rivalry. Rivalry dynamics (alternation rate, dominance, and piecemeal durations) were recorded before and after 2 min of rapid monocular stimulation (9Hz flicker of one grating) or a binocular control condition (9Hz alternation of the orthogonal gratings viewed binocularly). Rapid monocular stimulation did not affect alternation rates or piecemeal percept duration. However, unexpectedly, rivalry dominance of the stimulated eye was significantly reduced. A control experiment revealed that this effect could not be explained by monocular adaptation. Together, the results suggest that rapid monocular stimulation boosts dominance in the non-stimulated eye, possibly by activating homeostatic interocular gain control mechanisms.
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. (1993)

Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is a disorder of fatty acid catabolism, with autosomal recessive inheritance. The disease is characterized by episodic illness associated with potentially fatal hypoglycemia and has a relatively high frequency. A rapid and reliable method for the diagnosis of MCAD deficiency is highly desirable. Analysis of specific acylcarnitines was performed by isotope-dilution tandem mass spectrometry on plasma or whole blood samples from 62 patients with MCAD deficiency. Acylcarnitines were also analyzed in 42 unaffected relatives of patients with MCAD deficiency and in other groups of patients having elevated plasma C8 acylcarnitine, consisting of 32 receiving valproic acid, 9 receiving medium-chain triglyceride supplement, 4 having multiple acyl-coenzyme A dehydrogenase deficiency, and 8 others with various etiologies. Criteria for the unequivocal diagnosis of MCAD deficiency by acylcarnitine analysis are an elevated C8-acylcarnitine concentration (> 0.3 microM), a ratio of C8/C10 acylcarnitines of > 5, and lack of elevated species of chain length > C10. These criteria were not influenced by clinical state, carnitine treatment, or underlying genetic mutation, and no false-positive or false-negative results were obtained. The same criteria were also successfully applied to profiles from neonatal blood spots retrieved from the original Guthrie cards of eight patients. Diagnosis of MCAD deficiency can therefore be made reliably through the analysis of acylcarnitines in blood, including presymptomatic neonatal recognition. Tandem mass spectrometry is a convenient method for fast and accurate determination of all relevant acylcarnitine species.
Microwave Induced Effects on the Random Telegraph Signal in a MOSFET (2005)

We study the random telegraph signal (RTS) due to defects at the Si/SiO2 interface of a MOSFET in a microwave field. We observe the change of the characteristic times of the RTS by monitoring the drain current in such device operated under microwave irradiation and the change of the emission/capture time ratio. The random telegraph signal is examined as a function of the microwave power from the temperature of 1.6K to room temperature. We observe a common trend in the RTS modification for all the investigated traps at all temperatures. The effect of increasing the irradiated power is to decrease the emission and capture times, while their ratio may depend on the temperature.
Capon's Time-Frequency Representation with Nonstationary AR Autocorrelation (2006)

A novel approach for the spectral analysis of nonstationary signals is presented. For this purpose, Capon's time frequency representation (CTFR) is employed. It is shown that CTFR is an upper bound on the range of nonunique solutions for power estimation of a complex sinusoid contaminated with unknown noise. A new local autocorrelation function using a nonstationary auto-regressive (NAR) model is defined and used in CTFR. This method efficiently models the autocorrelations of NAR processes. Synthetic signals are generated in order to illustrate the superiority of CTFR with the NAR model in comparison to other methods.
Online load balancing under graph constraints (2013)

In several data center settings, each arriving job may only be served by one of a subset of servers. Such a graph constraint can arise due to several reasons. One is locality of the data needed by a job; for example, in content farms (e.g. in Netflix or YouTube) a video request can only be served by a machine that possesses a copy. Motivated by this, we consider a setting where each job, on arrival, reveals a deadline and a subset of servers that can serve it. The job needs to be immediately allocated to one of these servers, and cannot be moved thereafter. Our objective is to maximize the fraction of jobs that are served before their deadlines. For this online load balancing problem, we prove an upper bound of 1-1/e on the competitive ratio of non-preemptive online algorithms for systems with a large number of servers. We propose an algorithm - INSERT RANKING - which achieves this upper bound. The algorithm makes decisions in a correlated random way and it is inspired by the work of Karp, Vazirani and Vazirani on online matching for bipartite graphs. We also show that two more natural algorithm, based on independent randomness, are strictly suboptimal, with a competitive ratio of 1/2.
Increased morbidity and mortality in patients with diabetes mellitus after kidney transplantation as compared with non-diabetic patients (1992)

The results of renal transplantation in patients with juvenile-onset diabetes mellitus were compared to those of a well-matched control group of non-diabetic patients. All transplantations were performed between 1977 and 1988. In the diabetic group hypertension (72 versus 41%), coronary artery disease (17 versus 0%), and peripheral vascular disease (19 versus 0%) had been significantly more frequent pretransplantation. Fewer diabetic patients had previously been treated with dialysis therapy (69 versus 97%). Graft function measured by creatinine clearance after 1 year follow-up, and incidence of proteinuria were not significantly different. The overall graft survival was significantly worse in the diabetic group compared to the control group: 42 versus 69% after 60 months and 21 versus 62% after 90 months. This was caused by a significantly worse patient survival in the diabetic group after 105 months: 28 versus 78% in the control group. The graft survival following exclusion of the patients who died with a functioning graft did not differ significantly between the groups after 60 and 90 months: 62 and 31% in the diabetic group and 69 and 62% in the control group. The existence of any vascular disease before transplantation, especially pre-existing peripheral vascular disease, had a significant effect on mortality in diabetic patients (P = 0.0003). After transplantation, diabetic patients had significantly more cerebrovascular accidents (23 versus 3%), peripheral vascular disease (31 versus 3%), and number of infections (1.9 versus 1.2). Retransplantation was carried out in each group to the same extent, with the same success rate.
Supplementary Figure S1 from Human Leukocyte Antigen–Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer (2023)

&lt;p&gt;RL21A is specific for the HLA-A2/MIF&lt;sub&gt;19-27&lt;/sub&gt; complex.&lt;/p&gt;
A <i>Brevibacillus choshinensis</i> System That Secretes Cytoplasmic Proteins (2004)

Brevibacillus choshinensis has previously been shown to be a useful strain for the secretion of heterologous proteins via the Sec secretory pathway. This pathway involves the secretion of proteins prior to folding, whereas the alternative TAT (twin-arginine translocation) pathway enables pre-folded proteins to be secreted. We have modified the signal peptide of the Brevibacillus expression vector pNCMO2 to accommodate a Sec avoidance signal as well as the twin arginines required for secretion via the TAT system. Use of this modified signal peptide with the phosphotriesterase OpdA enabled B. choshinensis transformants to express and secrete the enzyme in an active and substantially pure form. The system was also used successfully to secrete two cytoplasmic proteins, the phosphotriesterase HocA from Pseudomonas monteilii and the phenylcarbamate-degrading enzyme, PCD, from Arthrobacter oxydans. The inhibitors carbonyl cyanide m-chlorophenyl hydrazine and sodium azide were used to confirm that secretion was occurring via the TAT secretion pathway. The modified B. choshinensis system we have developed may have general utility in secreting a wide range of heterologous proteins in active and conveniently processed form.
Bipolar Host Materials for Green Triplet Emitter in Organic Light-emitting Diodes (2007)

Abstract We have developed novel bipolar host materials for high efficiency green phosphorescent OLEDs (PHOLEDs). Phenyl moieties were inserted in a 9,9′-(biphenyl-4,4′-diyl)dicarbazole (CBP) compound to provide much easier electron injection and to increase electron mobility. The efficiency increase and voltage reduction by this modification were observed in green PHOLEDs. At a given constant luminance of 1000 cd/m2, the power efficiency was enhanced about twenty percent in the general green PHOLED devices.
Accurate Nonendoscopic Detection of Barrett's Esophagus by Methylated DNA Markers: A Multisite Case Control Study (2020)

Using a minimally invasive molecular approach, MDMs assayed from SOS samples show promise as a safe and accurate nonendoscopic test for BE prediction.
The security problems of Rivest and Shamir's PayWord scheme (2003)

The PayWord scheme was proposed by Rivest and Shamir for micropayments. This paper points out that it has the following problem: a malicious customer can damage the bank by purchasing in excess of the customer's credit which the bank has guaranteed by issuing the certificate. In general, there are two positions of the bank with regard to the certificate. Position 1: the bank takes full responsibility for the certificate and compensates all payments created by the customer's purchases; and Position 2: the bank doesn't redeem payments exceeding a limit set for the customer and shares the loss with the shop if trouble occurs. In the PayWord Scheme, the bank can reduce its risk by adopting Position 2 rather than Position 1. However, this paper points out that the bank can damage the shop in Position 2 by impersonating an imaginary customer and making the shop share the loss with the bank.
A Heterogeneously Integrated III-V/Si Colliding Pulse Mode-locked Laser with On-chip Feedback (2018)

We demonstrate a heterogeneously integrated O-band III-V/Si colliding pulse mode-locked laser with tunable on-chip external feedback for pulse stabilization. The 3-dB RF linewidth is 13.8 kHz, a reduction by a factor of 2.9× with the adjustment of external feedback.
Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase (2021)

Metabolic oligosaccharide engineering (MOE) has fundamentally contributed to our understanding of protein glycosylation. Efficient MOE reagents are activated into nucleotide-sugars by cellular biosynthetic machineries, introduced into glycoproteins and traceable by bioorthogonal chemistry. Despite their widespread use, the metabolic fate of many MOE reagents is only beginning to be mapped. While metabolic interconnectivity can affect probe specificity, poor uptake by biosynthetic salvage pathways may impact probe sensitivity and trigger side reactions. Here, we use metabolic engineering to turn the weak alkyne-tagged MOE reagents Ac<sub>4</sub>GalNAlk and Ac<sub>4</sub>GlcNAlk into efficient chemical tools to probe protein glycosylation. We find that bypassing a metabolic bottleneck with an engineered version of the pyrophosphorylase AGX1 boosts nucleotide-sugar biosynthesis and increases bioorthogonal cell surface labeling by up to two orders of magnitude. A comparison with known azide-tagged MOE reagents reveals major differences in glycoprotein labeling, substantially expanding the toolbox of chemical glycobiology.
Bonded-phase photopolymerized sol-gel monoliths for reversed phase capillary electrochromatography (2002)

A porous chemically modified photopolymerized sol-gel (PSG) monolith enhanced the capillary electrochromatographic separations of two test mixtures, one containing eight alkyl phenyl ketones and the other containing thiourea and three polyaromatic hydrocarbons. Derivatization of the PSG surface with silane coupling reagents resulted in bonded phases of pentafluorophenylpropyldimethyl, pentafluorophenyl, 3,3,3-trifluoropropyl, n-octadimethyl, perfluorohexyl, and aminopropyl. The fabrication of the bonded-phase PSG column is easy to do with the silanization reaction proceeding at room temperature for not longer than 60 minutes. The hydrophobicity of the PSG was altered without degrading its chromatographic performance. The bonded-phase PSG monoliths have higher stability at pH values below 4 as compared to the parent (underivatized) PSG. Separations of different mixtures containing nucleosides, positively charged peptides, and taxol derivatives illustrate the potential of bonded-phase PSG columns for the analyses of biologically and pharmaceutically important compounds. We report column efficiencies of up to 180 000 plates/meter and retention factors as large as 28.6 for decanophenone.
Adulthood consumption of preserved and nonpreserved vegetables and the risk of nasopharyngeal carcinoma: A systematic review (2006)

The incidence rates of nasopharyngeal carcinoma (NPC) are dramatically higher in certain regions of Asia compared to the rest of the world. Few risk factors for NPC are known; however, in contrast to the hypothesized health benefits of nonpreserved vegetables, it is thought that preserved vegetable intake may play a role in contributing to the higher incidence of NPC in high-risk regions. Therefore, the purpose of this study was to systematically review the epidemiologic evidence on the associations between adulthood intake of preserved and nonpreserved vegetables and NPC risk. A search of the epidemiological literature from 1966 to 2004 was performed using several bibliographic databases, including PubMed and the Chinese Biomedical Literature Database System. There were no language restrictions. Meta-analysis was conducted to obtain pooled odds ratios (ORs) for the highest-versus-lowest categories of preserved and nonpreserved vegetable intake. A total of 16 case-control studies were identified in the search. Results showed that highest-versus-lowest preserved vegetable intake was associated with a 2-fold increase in the risk of NPC (Random Effects Odds Ratio (RE OR) 2.04; 95% Confidence Limits (CL) 1.43, 2.92). Conversely, high nonpreserved vegetable intake was associated with 36% decrease in the risk of NPC (RE OR 0.64; 95% CL 0.48, 0.85). Findings for both preserved and nonpreserved vegetables were consistent across vegetable type and by country of study. Further research in high-risk areas to gain insight into the risk associated with preserved vegetables and protection associated with nonpreserved vegetables may advance understanding of NPC and yield clues for prevention.
Extending the Anomalous Dilation in CO2 to Thick Polymer Blend Films: A Neutron Reflectivity Study (2016)

We investigated the effect of density fluctuation of supercritical carbon dioxide (scCO2) on anomalous swelling of multilayer polymer thin films on the ridge in the pressure–temperature phase diagram of CO2. In order to measure the swelling ratio along the film depth, we alternately deposited hydrogenated poly(methyl methacrylate) (PMMA) and deuterated polystyrene (dPS) thin films and performed the neutron reflectivity measurements as a function of CO2 pressure at 36 °C. The results showed that, in contrast to previous studies, CO2 was to penetrate deeply throughout the multilayer thin film where the magnitude of swelling along the density fluctuation ridge of CO2 was independent of film thickness. Block copolymer thin films of dPS-b-PMMA with a parallel lamellar orientation also showed similar swelling behavior in scCO2. However, it is well-known that single-layer polymer thin films exhibit anomalous swelling behavior only near the film surface. This difference is probably due to the fact that the multilayer thin films have the CO2-philic PMMA layer sandwiched between dPS layers, which can function as a CO2 reservoir, thereby transferring the CO2 molecules from the PMMA layers to the adjacent dPS layers. Furthermore, we found that the interaction between polymers and substrates was not significant in scCO2 from diffusion dynamics results using neutron reflectivity, thereby facilitating anomalous dilation of polymers near the substrates without a pinning effect.