gebhart/patrepeval huggingface dataset:
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1DAdrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities (2016)

A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through screening of an in-house compound library. From initial structure-activity relationship studies, we found lead compound 9m with hERG K(+) channel liability. To develop analogues with reduced hERG K(+) channel inhibition, a combination of site-directed mutagenesis and docking studies was employed. Further optimization led to the discovery of (R)-9s and 9u, which showed antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, as well as ameliorated cystitis-induced urinary frequency in rats. Ultimately, 9u was selected as a clinical candidate. This is the first study to show the utility of iminopyridine derivatives as selective α1D-AR antagonists and evaluate their effects in vivo.
Single Wall Carbon Nanotube Response to Proton Radiation (2009)

In the interest of developing a highly sensitive, low power radiation dosimeter, a series of tests were performed on single-wall carbon nanotube (SWCNT)-based nanomaterials to monitor their response to 10 and 30 MeV proton radiation. The SWCNT materials were deposited on an interdigitated electrode (IDE) that was developed at NASA Ames for chemical sensing. In order to investigate the effects of nanotube functionalization on the sensor properties, the SWCNTs were covalently or noncovalently functionalized prior to their incorporation into the devices. The functionalized nanotubes which were assayed included fluorinated SWCNT (F-SWCNT), alkylated F-SWCNT (F-SWCNT-C11H23), refluorinated alkylated F-SWCNT (F-SWCNT-C11F23), palladium doped SWCNTs (Pd-SWCNTs), and nanotubes noncovalently associated with cellulose (Cel-SWCNTs). These five functionalized nanotube types and pristine carbon nanotubes were investigated for their responses to proton radiation. The device response to irradiation, measured as a change in resistance, was found to vary with the type of functional group attached to the SWCNT. The samples were also characterized by Raman spectroscopy in order to observe changes in the disorder band (at 1350 cm−1) of the nanotube materials. Depending on nanotube functionalization, the devices showed a real-time response to radiation at the energy levels tested. The nature of the response indicates that these nanomaterials may potentially be used to produce a dosimeter that is memory-free, reusable, and reversible.
Continuous-Flow Left Ventricular Assist Device Explantation After More Than 5 Years of Circulatory Support and Ventricular Reconditioning (2021)

Continuous-flow left ventricular assist devices have proved to be effective, durable, life-saving tools in patients with end-stage heart failure. However, because of the risks associated with mechanical circulatory support (including stroke, infection, gastrointestinal bleeding, and device malfunction), the optimal goal of device therapy is myocardial recovery and device removal. Ventricular reconditioning and pump explantation after continuous-flow support have been reported; however, little is known about variables that govern the pace and degree of myocardial response in patients who experience such recovery. We describe our long-term pump-weaning strategy for a 25-year-old man who had a continuous-flow device implanted and then needed more than 5 years of support from it before developing cardiac reserve sufficient to enable pump explantation. To our knowledge, this is the longest period of uninterrupted continuous-flow device support to end in successful pump deactivation and a return to medical therapy. This case highlights the importance of actively and persistently pursuing a device-weaning strategy in all patients who need left ventricular assist device therapy.
Measurement and ray-tracing prediction of indoorchannel parameters (1998)

A 3D ray tracing (RT) tool is validated by comparison with measurement in a typical office building. RT shows good reproduction of path loss, even if a slight bias emerges as the radio link distance exceeds 12–14 m. The spatial correlation of the field, which strongly depends on multipath, is accurately predicted by RT independently of distance. This gives confidence in the ability of RT to predict the overall multipath mechanism and the related propagation parameters.
A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals (2016)

Abstract Coral reefs, and the unique ecosystems they support, are facing severe threats by human activities and climate change. Our understanding of these threats is hampered by the lack of robust approaches for studying the micro-scale interactions between corals and their environment. Here we present an experimental platform, coral-on-a-chip, combining micropropagation and microfluidics to allow direct microscopic study of live coral polyps. The small and transparent coral micropropagates are ideally suited for live-imaging microscopy, while the microfluidic platform facilitates long-term visualization under controlled environmental conditions. We demonstrate the usefulness of this approach by imaging coral micropropagates at previously unattainable spatio-temporal resolutions, providing new insights into several micro-scale processes including coral calcification, coral–pathogen interaction and the loss of algal symbionts (coral bleaching). Coral-on-a-chip thus provides a powerful method for studying coral physiology in vivo at the micro-scale, opening new vistas in coral biology.
Nonreciprocity of counterpropagating signals in a monolithically integrated Sagnac interferometer: erratum (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Vinod M. Menon, Wilson Tong, Fengnian Xia, Chianqiang Li, and Stephen R. Forrest, "Nonreciprocity of counterpropagating signals in a monolithically integrated Sagnac interferometer: erratum," Opt. Lett. 29, 1156-1156 (2004) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Multiple Antenna Techniques for LTE‐Advanced (2011)

Multiple antenna techniques play a key role in long term evolution (LTE)-Advanced. This chapter explains the techniques adopted for Release 10 and gives some insight into additional multiple in multiple out (MIMO) enhancement features that may be developed in future releases of LTE-Advanced. In Release 10, SU-MIMO transmission with up to four spatial layers is introduced to increase the data rate for the Physical Uplink Shared CHannel (PUSCH) , and the reliability of the control signalling on the Physical Uplink Control CHannel (PUCCH) is increased using transmit diversity. Coordinated MultiPoint (CoMP) transmission/reception, also known as Cooperative MIMO, has received significant attention in academic literature and is being studied as a technique to increase performance, especially at the cell edge, within the evolution of LTE-Advanced for Release 11 or beyond. Controlled Vocabulary Terms antennas; long term evolution; MIMO systems
Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation (2010)

Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion for RAS-mediated carcinogenesis in mice in vivo and for MAPK activation and transformation in vitro. Mechanistically, MyD88 bound to the key MAPK, Erk, and prevented its inactivation by its phosphatase, MKP3, thereby amplifying the activation of the canonical RAS pathway. The relevance of this mechanism to human neoplasia was suggested by the finding that MyD88 was overexpressed and interacted with activated Erk in primary human cancer tissues. Collectively, these results show that in addition to its role in inflammation, MyD88 plays what we believe to be a crucial direct role in RAS signaling, cell-cycle control, and cell transformation.
Self-Assembled Ceramics Produced by Complex-Fluid Templation (2000)

This review examines the use of self-assembly in the fabrication of ceramic mesostructures, emphasizing the use of amphiphilic surfactants and block copolymers. The association between this area of research and biomimetics is discussed, linking developments in synthetic self-assembly with biomineralization. The fabrication of hierarchical structures through the use of simultaneous processing is shown to be a necessary condition for applications of this new technology.
Generalization of non-linguistic auditory perceptual training to syllable discrimination (2007)

Results showed that task-specific attention drives generalization of auditory perceptual training from non-linguistic to linguistic contexts. Furthermore, individual differences in initial perceptual performance affect the degree of generalization following training.
Decomposition and Stabilization of Drugs. XXI. Photodecomposition and Stabilization of Sodium Guaiazulene Sulfonate (1988)

グアイアズレンスルホン酸ナトリウムsodium 1, 4-dimethyl-7-isopropylazulene-3-sulfonate (I) は抗炎症, 抗アレルギー作用を有することから胃炎, 口内炎等の治療薬として使用されている. しかしながら, Iは熱光に対し不安定であり, 室内で保存すると徐々に退色, 分解してグアイアズレン (II) になることが報告されている (Chart 1).また, IはpH7.5-8.5附近の弱アルカリ性では安定であるが, pH5以下になると急激に分解することが知られている.これらIの水溶液中又は固体状態での分解反応及び安定化については種々の報告があるが, いずれも温湿度条件下による検討が主であり, 光照射条件下におけるIの分解反応や安定化についての詳細な報告は見あたらない.そこで著者らは, Iの光分解反応及びその安定化法を検討し, 錯体形成の観点から考察を加えた.
Optical gain in a neutron-induced 3He-Ne-O2 plasma (1976)

A single pass gain of ∼0.9% p/m (at 8446 Å in atomic oxygen) has been measured for a 3He-Ne-O2 plasma generated by the volumetric 3He(n,p)3H reaction induced by neutrons from a pulsed nuclear reactor. The plasma was contained in an optical cavity containing a chopping fan that permitted a measurement of the ratio of output 8446 Å from the normal cavity to that with the back mirror blocked. This ratio, called the unblocked-blocked ratio, was used to study the gain dependence on total pressure and concentration. The maximum gain observed was for a concentration of 0.048% O2 and 1.5% Ne, at a total pressure of 600 Torr. The peak gain remained fairly constant with neutron fluxes from 1013 to 2.5×1015 n/cm2 sec. Results of other concentration studies are also discussed. The laser medium is pumped by thermal neutrons from the Illinois TRIGA reactor that impinge on a 80-cm by 0.8-cm-i.d. glass tube containing from 50 to 800 Torr 3He-Ne-O2.
The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer (2007)

Mutations in the BRCA2 gene have been implicated in pancreatic cancer susceptibility through studies of high-risk breast and ovarian cancer families. To determine the contribution of mutations in BRCA2 to familial pancreatic cancer, we screened affected probands from 151 high-risk families identified through pancreatic cancer clinics for germ-line BRCA2 mutations. Of these families, 118 had two or more first- and second-degree relatives with pancreatic cancer, and an additional 33 had two or more affected second-degree relatives. The average age of onset for pancreatic cancer was 62.8 years. Five BRCA2 truncating mutations were identified, three in families with two or more first- and second-degree relatives with pancreatic cancer. Three of the families with mutations had a history of breast cancer but not ovarian cancer. Four of five families with mutations were identified through probands with early-onset (<55 years) pancreatic cancer. The results of this study were combined with those from a BRCA2 mutation study of 29 other families from the same Johns Hopkins University National Familial Pancreatic Tumor Registry to estimate the frequency of BRCA2 mutations. A total of 10 carriers from 180 families were identified, suggesting that BRCA2 mutations account for 6% of moderate and high-risk pancreatic cancer families.
Eight‐Membered‐Ring Lactams — New Scaffolds for Combinatorial Chemistry Prepared by Ring‐Expansion of 1,4‐Diketones with Primary Amines. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bi-unicondylar arthroplasty (2021)

Bi-UKA had more normal gait characteristics and improved patient-reported outcomes, compared to matched TKA subjects. This can, in part, be explained by differences in extensor efficiency. Cite this article: <i>Bone Joint Res</i> 2021;10(11):723-733.
Large-scale, long-time molecular dynamics simulations of lipid bilayers: Permeation and protein structure (1996)

Lipid bilayers form the foundation of biological membranes. As such, they have important roles in mediating the transport of small molecules into cells and maintaining the structure of transmembrane proteins. Realistic simulations must comprise many thousands of atoms and explicit water molecules. Pertinent biological timescales range from tens of picoseconds to seconds. We will discuss these timescales as they relate to the transport of small molecules within the bilayer construct. The timescales of movement of trans-membrane protein helics will also be addressed. Due to their size and long timescales, methods that allow for simulation of large systems for long periods will be important advances. We will discuss simulations of these systems on massively-parallel machines. Further, the highly-charged nature of lipid molecules requires that long-range coulombic interactions be employed. We will discuss the application of long cutoffs, Ewald sum, and the particle-particle-particle mesh method.
Perceived barriers &amp; facilitators for bedtime routines in families with young children living in economically deprived areas (2020)

Abstract Background: Bedtime routines are a highly recurrent family activity with important health, social and behavioural consequences. Despite their importance, information regarding formation, establishment and maintenance of bedtime routines remains limited. This study examined perceived barriers to, and facilitators of, formulating, establishing and maintaining optimal bedtime routines in families with young children from deprived socio-economic areas.Methods: A total of 12 parents participated in the study. Most participants (N=11) were females, had between 1 and 2 children (N=10), were white (N=9) and stay at home parents (N=6). They completed a semi-structured interview based on the Theoretical Domains Framework (TDF). Analysis followed a deductive, theory-informed mapping approach.Results: Key barriers included lack of appropriate knowledge and sources of information, problematic skills development, social influences, cognitive overload, lack of self-monitoring, lack of motivation and negative emotions. Facilitators included social role/identity, environment/access to resources, positive intentions, beliefs about consequences and reinforcement. In particular, optimal bedtime routines were less likely to be enacted when parents were tired/fatigued and there was a strong effect of habit, with suboptimal routines maintained over time due to past experiences and a lack of awareness about the contents and importance of a good bedtime routine. Conclusions: Several theory-based, and potentially modifiable, determinants of optimal bedtime routines were identified in this study, providing important information for future interventions. Several of the key determinants identified were transient (tiredness) and/or non-conscious (habit), suggesting that future interventions may need to be deployed in real time, and should extend beyond conventional techniques.
Bone Regeneration: Membranes for Guided Bone Regeneration: A Road from Bench to Bedside (Adv. Healthcare Mater. 19/2020) (2020)

Membranes for guided bone regeneration (GBR) strategies are a class of medical devices (MDs) developed to elicit new bone formation by protecting the defect site. In article number 2000707, Didier Letourneur and co-workers elucidate the complex scientific translation of biomaterials for such a class of MDs. Hence, the focus in their review is set on the latest advancements in GBR membranes, their regulatory framework, and the industrialization process that brings these MDs to market.
Supplementary Table S1 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers (2023)

&lt;p&gt;Overall and sub-cohort based longitudinal (24 hours to 24 months) test statistics for proteomics data set comparing each time post-RT to baseline for the prostate cancer cohort.&lt;/p&gt;
Clinical and Pathologic Features of Secondary Acute Promyelocytic Leukemia (2012)

Acute promyelocytic leukemia (APL) is a relatively common form of acute myeloid leukemia (AML) that has an excellent prognosis. In contrast, secondary acute myeloid leukemias, including therapy-related AML and AML with myelodysplasia-related changes, have a relatively poor prognosis. We identified 9 cases of APL at our institution in which there was a history of chemotherapy, radiotherapy, chronic immunosuppression, or antecedent myelodysplastic syndrome. The clinical and pathologic findings in these cases of secondary APL were compared with the clinical and pathologic findings in cases of de novo APL. We found that secondary and de novo APL had abnormal promyelocytes with similar morphologic and immunophenotypic features, comparable cytogenetic findings, comparable rates of FMS-like tyrosine kinase mutations, and similar rates of recurrent disease and death. These data suggest that secondary APL is similar to de novo APL and, thus, should be considered distinct from other secondary acute myeloid neoplasms.
Galanin Inhibits Cholecystokinin Secretion in STC-1 Cells (1995)

Neuropeptides such as gastrin releasing peptide and pituitary adenylate cyclase activating polypeptide (PACAP) stimulate CCK secretion from CCK producing cells. We hypothesized that in addition to somatostatin, galanin may also play an inhibitory role on CCK secretion. The effect of galanin on CCK secretion was studied in a CCK-producing murine neuroendocrine tumor cell line, STC-1. Galanin below 10 nM did not affect basal CCK secretion but dose- and time-dependently inhibited KCl-stimulated CCK secretion. Galanin also inhibited forskolin-, bombesin- and PACAP- but not dibutyryl cAMP- or beta-TPA-stimulated CCK secretion. The inhibitory effect of galanin was reduced partially by a blocker of ATP-sensitive K+ channel (K+ ATP), glibenclamide, and prevented by pretreatment of the cells with PTX. The results indicated galanin regulates CCK secretion by modulation of K+ ATP and cAMP production through receptors coupled to a PTX-sensitive G protein.
Application of Engineered Si Nanoparticles in Light-Induced Advanced Oxidation Remediation of a Water-Borne Model Contaminant (2016)

Surface-engineered amphiphilic polymer-coated silicon nanoparticles (SiNPs) were employed as photocatalysts to capture and degrade a model organic contaminant (methanol) in water. This study represents the first time SiNPs have been employed in the initiation of advanced oxidation processes that are commonly used to degrade organic constituents in industrial wastewaters. The quantum yield of photocatalytic methanol oxidation and the corresponding yield factor for the generation of active OH radicals are reported. The size and surface defect dependent photocatalytic activity of SiNPs was investigated. The yield factors (η) decreased with increasing particle size and reached impressive values that exceeded that of equivalent TiO2 nanoparticle systems by 3-4 times and are comparable to the robust UV/Cl2 and UV/H2O2 systems. The higher photocatalytic efficiency of SiNPs is attributed to the combined effects of quantum confinement, effective band gap, and surface states, among which surface states play a dominant role. SiNPs provide a potentially tunable, biologically inert, and robust nanoparticle system for photocatalytic oxidation of wastewater contaminants.
ChemInform Abstract: α‐Activated Cross‐Conjugated Cycloalkenone Systems in Organic Synthesis (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On upper bounds for the distance of codes of small size (2002)

Combining a linear programming approach with the Plotkin-Johnson argument for constant weight codes, we derive upper bounds on the size of codes of length n and minimum distance d=(n-j)/2, 0<j<n/sup 1/3/. For j=o(n/sup 1/3/) these bounds practically coincide with the Tietavainen bound (1980) and are slightly better. For fixed j and j proportional to n/sup 1/3/, j<n/sup 1/3/-(2/9)ln n, it improves on the earlier known results.
TMOD-10. METABOLIC AND BLOOD-BRAIN BARRIER MARKERS FOR FLUORESCENCE-GUIDED SURGERY: SYSTEMATIC HIGH-RESOLUTION MICROSCOPY INVESTIGATION IN HUMAN RELEVANT EXPERIMENTAL GLIOMAS (2018)

Fluorescence guidance with 5-aminolevulinic acid(5-ALA) increases resection extent and may benefit surgical outcomes in high-grade gliomas. We investigated if a combination of various fluorescence guidance techniques can provide further advantage. We systematically assessed and compared the fluorescent patterns of 5-ALA-induced protoporphyrin IX (PpIX), fluorescein sodium(FNa) and indocyanine green(ICG) to identify GL261 gliomas in mice and RFP-U251 gliomas in rats. 5-ALA(5mg), FNa(5 mg/kg) and ICG(20mg/kg) were administered perioperatively. Fluorescence patterns were recorded with operative microscope, laser scanning confocal microscope, and confocal laser endomicroscope. Fluorescence was assessed quantitatively as a surface area of fluorescent positive tissue and qualitatively(false/true, positive/negative) as compared to HE-stained histology. FNa highlighted a larger surface area(18.0mm2) than white light(16.9mm2,p=0.016) or PpIX (16.0mm2,p=0.035). Both 5-ALA and FNa showed inhomogeneous staining patterns: multiple areas of equal staining, when PpIX was present and FNa was not, and vice versa. ICG was visible in 8/31 tumor samples, all immediately after injection. ICG did not reveal clear tumor margins, but stained non-tumor tissue and nearby vasculature. FNa signal was stronger (tumor to background ratio (TBR)1.93 ± 0.56) compared to 5-ALA(1.52 ± 0.31;p ICG highlighted tumor only within the first few minutes and stained mostly hypervascularized areas. Confocal and surgical imaging revealed inhomogeneous tumor border staining with PpIX/FNa. Simultaneous administration of 5-ALA and FNA may provide additional benefit. Neither ICG, 5-ALA or FNa worked perfectly, emphasizing the need for more specific markers for fluorescence-guided brain tumor resection.
Multiplexed DNA Detection with Biobarcoded Nanoparticle Probes (2006)

Sorting the mail: A highly selective assay for the detection of multiple DNA targets in solution was developed based on gold nanoparticles with oligonucleotide reporters. Four DNA targets associated with infectious viruses were detected simultaneously without enzymatic amplification at mid-femtomolar concentrations.
Selective Permeation of Nitric Oxide through Two Dimensional Cross-linked Polysiloxane LB Films (2002)

Abstract Novel two-dimensional (2D) cross-linked polysiloxane LB films were prepared and applied to nitric oxide (NO)-permselective films in order to block other electroactive interfering substances, such as l-ascorbic acid, l-cysteine, and acetaminophen. The 2D cross-linked siloxane LB films deposited on Pt electrodes were remarkably effective in the elimination of the interfering responses and a rapid response to NO remained with modified LB films consisting of monolayers or even several layers.