gebhart/patrepeval huggingface dataset:
Transducin‐mediated, isoform‐specific interaction of recombinant rat nucleoside diphosphate kinases with bleached bovine retinal rod outer segment membranes (1996)

The properties of the binding of recombinant rat nucleoside diphosphate (NDP) kinase isoforms alpha and beta (NDP kinase alpha and beta, respectively) to bleached bovine retinal rod outer segment (ROS) membranes were investigated. It was found that: (1) both NDP kinase isoforms interacted with ROS membranes in a pH-, cation- and GTPgammaS-dependent manner; (2) the retinal G-protein transducin was an obligatory factor for the interaction; (3) the apparent affinity of NDP kinase alpha for ROS membranes was about 100-fold higher than that of NDP kinase beta; and (4) an alpha-isoform-specific peptide, corresponding to the sequence of the N-terminal third (variable region), had the ability to displace bovine NDP kinase from ROS membranes. The results suggest the possible involvement of NDP kinases in cellular regulation via interaction with G-proteins and provide a structural basis for the possible differential roles of mammalian NDP kinase isoforms in the cell.
Photochemically Induced Crystallization of Proteins Accelerated on Two-Dimensional Gold Gratings (2012)

The photochemically induced crystallization of lysozyme was studied on a two-dimensional surface relief grating coated with a thin gold film (2D-plasmonic chip), a flat thin gold film, and a flat UV-curable resin. The lysozyme solution prepared in a metastable compositional region was dropped on each surface. After an exposure to visible light from a filtered Hg lamp (500 and 800 nm in wavelength, 1.5 W/cm2) for 30 min followed by 18 h keeping in the dark, the crystal particles were observed in the droplets. Under a microscope, the numbers of crystalline particles were counted to be 1280, 258, and 180 on the 2D-plasmonic chip, the flat gold film, and the flat UV-curable resin, respectively. It was suggested that the crystallization tendency of lysozyme was effectively accelerated by the enhanced electric field caused by the coupling of incident light with surface plasmon polaritons on the 2D-plasmonic chip.
Current Approaches to the Development of a Vaccine Against Filarial Nematodes (2012)

This chapter contains sections titled: Introduction to anti-filarial nematode vaccines Anti-O.volvulus and anti-LF vaccines are a valid approach to advance control measures against onchocerciasis and lymphatic filariasis Future directions for vaccine development Discovery of new vaccine candidates References for further reading
Light-induced domain engineering in ferroelectrics: a route to sub-micron poling (2006)

While several techniques to achieve domain inversion in ferroelectric materials such as lithium niobate and lithium tantalate have been successfully demonstrated over the past years, even the 'best' established technique of electric field-induced domain inversion (E-field poling) fails when domain inversion at periodicities of a few microns and below are desired. In order to overcome the limitations associated with E-field poling, we have been investigating the feasibility of a relatively simple single-step technique, which exploits the interaction of intense laser light with ferroelectric materials to engineer their domains at micron and sub-micron scale-lengths. Some light-assisted poling experiments, which take advantage of the ultraviolet light induced transient change in the coercive field of the illuminated ferroelectric material to transfer a patterned light distribution into an equivalent domain structure in bulk crystals have already been reported for lithium niobate [1,2] and lithium tantalate [3,4] crystals.&lt;br/&gt;&lt;br/&gt;We have earlier reported a direct all optical poling (AOP) technique that employs pulsed ultraviolet (UV) laser light to induce surface domain inversion on the +[5] and -[6] z-faces of lithium niobate in a single step, We have been trying to understand the physical principles involved in light-matter interaction with an aim of controlling the shape, size and depth of the randomly orientated light-induced domains with an end goal of tailoring periodic structures in lithium niobate. This report presents the results of our attempts to achieve a degree of control over the nucleation and growth of the domains, via an imposed incident light pattern produced using a phase-mask. It is shown that it is possible to align the surface domains along the maxima of the spatially modulated UV laser light pattern.
Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli (2009)

Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary catheters were impregnated with gaseous NO. The catheters demonstrated slow release of nitric oxide over a 14-day period. The charged catheters were rendered antiseptic, and as such, were able to prevent bacterial colonization and biofilm formation on their luminal and exterior surfaces. In addition, we observed that NO-impregnated catheters were able to inhibit the growth of Escherichia coli within the surrounding media, demonstrating the ability to eradicate a bacterial concentration of up to 10(4) CFU/ml.
GW24-e3563 Clinical application of min-diameter atria stleel-wire in modified percutaneous ballon mitral valvuloplasty (2013)

Objectives To evaluate the feasibility, safety and efficacy of the min- diameter half and two convolutionsatria steel-wire that is used in improving percutaneous balloon mitralvalvuloplasy (PBMV) Methods All patients received warfarin tabella every day for more than 3 months, underwent PBMV with the min-diameter half and two convolutions atria steel-wire and single balloonInoue technique after low dosage urokinase intravenous drip and Low Molecular Heparin injectio hypodermica every day for 5 days to observe the changes of haemodynamics and mitralvalve orifice area after PBMV. Following-up pulmonary arterial pressure inner diameter of left atrium complication as systematic thromboembolism Results The achievement ratio was 98.9%. After PBMV, mean left atrial pressure (LAPm) and mean mitrial valve pressure gradient (MVPG) decreased from (28.5 ± 3.2) mmHg and (16.8 ± 3.8) mmHg to (10.3 ± 2.1) mmHg (P &lt; 0.05) and (3.4 ± 2.8) mmHg (P &lt; 0.01) respectively; Mitral valve orificearea (MVA) increased from (0.86 ± 0.26) cm 2 to (1.67 ± 0.34) cm 2 (P &lt; 0.01). 6 months after PBMV Left atrial diameter (LAD) decreased from (65.30 ± 3.4) mm to (46.5 ± 4.3) mm (P &gt; 0.05); Pulmonary pressure (PP) decreased from (63.8 ± 12.3) mmHg to (31.5 ± 12.7) mmHg (p &lt; 0.05). 46 patients of heart function (NYHA) II to heart function I in 52 patients, 8 patients of heart function (NYHA) IIIto heart function II in 11 patients. No systemic thromboembolism occurred during PBMV and following-up. Conclusions PBMV on patients after sufficient anticoagulation and thrombolysis combine the min- diameter half and two convolutions atria steel-wire that is used in improving single balloon Inoue technique is safe, feasible and effective.
Photoionization Threshold of Perylene on Water Surface as Measured by Synchrotron Radiation (1998)

Abstract Photoionization efficiency of perylene on water surface was measured in the 165-260 nm region by synchrotron radiation. The photoionization threshold was determined to be 5.9 eV and agreed well with that determined in the laser two-photon ionization. This finding indicates that the water surface is more hydrophobic than its bulk.
Circulating tumor DNA alterations in patients with metastatic castration‐resistant prostate cancer (2019)

ctDNA frequently was detected in this large cohort of "real-world" patients with mCRPC, and the alterations appeared to be similar to previously reported tumor tissue alterations. A higher number of alterations, and AR and MYC alterations, appear to compromise clinical outcomes, suggesting a role for immune checkpoint inhibitors and novel AR and BET inhibitors in selected patients.
A Power-Performance Approach to Comparing Sensor Families, with application to comparing neuromorphic to traditional vision sensors (2015)

There is considerable freedom in choosing the sensors to be equipped on a robot. Currently many sensing technologies are available (radar, lidar, vision sensors, time-of-flight cameras, etc.). For each class, there are additional choices regarding the exact sensor parameters (spatial resolution, frame rate, etc.). Which sensor is best? In general, this question needs to be qualified. It depends on the task. In an estimation task, the answer depends on the prior for the signal. In a control task, the answer depends exactly on which are the sufficient statistics for computing the control signal. This paper shows that an ulterior qualification that needs to be made: the answer depends on the power available for sensing, even when the task is fixed. We define the “power-performance” curve as the performance attainable on a task for a given level of sensing power. We show that this approach is well suited to comparing a traditional CMOS sensor with the recently available “neuromorphic” sensors. We discuss estimation tasks with different priors for the signal. We find priors for which one sensor dominates the other and vice-versa, priors for which they are equivalent, and priors for which the answer depends on the power available. This shows that comparing sensors is a quite delicate problem. It also suggests that the optimal architecture might have more that one sensor, and would switch sensors on and off according to the performance level required instantaneously.
mmobilization and bacterial utilization of dissolved organic carbon entering the riparian zone of the alpine Enns River, Austria (2001)

In order to understand the factors controlling the removal of riverine dissolved organic carbon (DOC) in the riparian zone of an alpine river, concentrations of DOC and dissolved oxygen, as well as bacterial abundance and production, were determined in interstitial waters of an experimental bank filtration site of the Enns River, Austria. Four porewater stations exhibiting differing sedimentologic and hydrologic characteristics were sampled over an annual cycle. We found that concentrations of DOC, oxygen, bacterial biomass and production decreased significantly within the first meter from the sediment-water interface. Differences in the grain size distribution among the sampling stations led to spatial heterogeneity in the permeability of the riparian sediments and in the hydraulic residence time of the infiltrating river water, resulting in specific patterns in DOC immobilization and microbial respiration. Porewater bacterial abundance and production and apparent microbial oxygen consumption were positively correlated with the hydraulic residence time of the infiltrating water. DOC occasionally accumulated in the shallow porewater layers during the winter. During the summer, DOC infiltrating from the river surface potentially explained only 36 25% of the apparent interstitial oxygen consumption. This suggests that particulate organic carbon (POC) contributes substantially to the microbial organic carbon supply in the hyporheic zone. We conclude that the availability of POC rather than DOC infiltration determines hyporheic microbial metabolism.
Anti-Tumor Effects From Dendritic Cell-Based Cancer Immunotherapy Using Liposomal Bubbles and Ultrasound (2011)

Dendritic cell (DC)‐based cancer immunotherapy has the potential to be a minimally invasive therapy that could prevent cancer metastasis and recurrence. Recently, in order to induce effective anti‐tumor immunity, we developed a novel antigen delivery system for DCs by the combination of ultrasound (US) and liposomal bubbles (Bubble Liposomes: BLs) with entrapped perfluoropropane gas. In this study, we investigated the induction of antigen specific immune responses in vivo and the anti‐tumor effect caused by immunization of DCs treated with BLs and US. For the immunization of DCs which had delivered antigen, using BLs and US, the mice induced antigen specific cytotoxic T lymphocytes (CTLs) were found to be the main effector cells in DC‐based cancer immunotherapy. In addition, immunization with DCs that had been pulsed with antigen using BLs and US completely suppressed tumor growth Therefore, immunization of DCs with this antigen delivery system has promise for the efficient induction of anti‐tumor immune responses.
Resected pancreatic ductal adenocarcinomas with recurrence limited in lung have a significantly better prognosis than those with other recurrence patterns (2015)

The majority of patients with curative resection of pancreatic ductal adenocarcinoma recur within 5 years of resection. However, the prognosis associated with different patterns of recurrence has not been well studied. A retrospective review of patients who underwent curative surgical resection of pancreatic cancer was performed. Of the 209 patients, 174 patients developed recurrent disease. Of these 174, 28(16.1%) had recurrent disease limited to lung metastases, 20(11.5%) had recurrence in the lung plus one or more other sites excluding the liver, 73(42.0%) had liver metastasis alone or liver metastasis with any other site except lung, 28(16.1%) local recurrence only, and 25(14.3%) peritoneal recurrence alone or together with local recurrence. Patients with recurrence limited to lung had a 8.5 months(Mo) median survival from recurrence to death, which was significantly better than the survival associated with recurrence in the liver(5.1Mo), in the peritoneum(2.3Mo) or locally(5.1Mo) in multivariable analyses. Among all groups, the time from surgery to the diagnosis of recurrence in patients who recurred in only in the lung was also the longest. However, 75% of patients were found to have indeterminate lung nodules on their surveillance CT scans prior to the diagnosis of recurrence in lung. This delayed diagnosis of lung recurrence may have a negative impact on survival after recurrence. In conclusion, pancreatic cancer with lung recurrence has a significantly better prognosis than recurrence in other sites. Further studies are needed to investigate how different diagnostic and treatment modalities affect the survival of this unique subpopulation of pancreatic cancer patients.
A 19–40 GHz bi-directional MEMS tunable all silicon evanescent-mode cavity filter (2017)

This paper presents, for the first time, a new tuning technology based on bi-directional MEMS actuators for high-quality all-silicon evanescent mode cavity filters. Such bi-directional tunability provides a feasible solution to restore frequency tunability from degradation caused by aging effects such as creep and stress relaxation. The fabricated proof-of-concept filter demonstrates a measured tuning range from 18.9 to 39.6 GHz, in which the forward (main) actuation tunes from 21.3 to 39.6 GHz with 120 V and the reverse (corrective) actuation tunes from 21.3 down to 18.9 GHz with 2 V. The measured filter insertion loss varies from 3.14 to 0.78 dB and its instantaneous bandwidth from 0.31 to 1.81 GHz. The unloaded quality factor is extracted as 265-510 which is comparable to the state-of-the-art filter of this type employing conventional uni-directional tuners.
Stability of a 4 degree of freedom rotor on electrodynamic passive magnetic bearings (2014)

Electrodynamic bearings exploit repulsive forces due to eddy currents to produce positive stiffness by passive means without violating the Earnshaw stability criterion. This remarkable characteristic makes this type of bearing a suitable alternative to active magnetic bearings in fields such as kinetic energy storage flywheels, turbo pumps, high speed compressors, among others. However, the suspension can become unstable due to rotating damping. To obtain deeper understanding of this instability phenomenon this paper presents the analysis of stability of a four degree of freedom (4dof) rotor supported by electrodynamic bearings. The 4dof rotor model is coupled to the dynamic model of the eddy current forces generated by the electrodynamic bearing and the stability of the complete system is analyzed. This model is used to study the stability of both cylindrical and conical whirling motion of the rotor. In addition to the well known cylindrical whirl instability the possible occurrence of conical instability is demonstrated. Finally the effects of two stabilization strategies are analyzed
Figure 2 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities (2023)

&lt;p&gt;&lt;b&gt;A,&lt;/b&gt; Schematic describing IUE-based H3&lt;sup&gt;K27M&lt;/sup&gt;-driven brain tumor modeling. Different combinations of piggyBac and CRISPR vectors are delivered into NSCs lining the LRL at E12.5. After birth, mice develop tumors representing distinct DMG subtypes. Inset: mutation combinations represented in H3&lt;sup&gt;K27M&lt;/sup&gt; models and the acronyms used to refer to them. &lt;b&gt;B,&lt;/b&gt; Immunofluorescence and IHC detection of GFP, K27M, Ki-67, and hematoxylin and eosin (H&amp;E) in coronal hindbrain sections from tumor-bearing, symptomatic mice. Embryos were electroporated with vectors encoding (i) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, p53&lt;sup&gt;LOF&lt;/sup&gt;, PDGFRA&lt;sup&gt;WT&lt;/sup&gt; (KPP); (ii) H3.1&lt;sup&gt;K27M&lt;/sup&gt;, ACVRA&lt;sup&gt;G328V&lt;/sup&gt;, PIK3CA&lt;sup&gt;E545K&lt;/sup&gt; (H3.1KACVPIK); (iii) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, PPM1D&lt;sup&gt;ΔC&lt;/sup&gt;, PIK3CA&lt;sup&gt;E545K&lt;/sup&gt; (KPPMPIK); and (iv) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, NF1&lt;sup&gt;LOF&lt;/sup&gt;, FGFR1&lt;sup&gt;N457K&lt;/sup&gt; (KNF). Tumor cells are GFP&lt;sup&gt;+&lt;/sup&gt;. Higher magnification panels below each low-magnification panel are of the tumor bulk in the brainstem, i.e., pons and medulla, which are directly below the cerebellum and fourth ventricle. Scale bars represent 1 mm in the immunofluorescence panels and 200 μm in the IHC panels. &lt;b&gt;C,&lt;/b&gt; Immunofluorescence of tumor tissue sections in the pons or medulla to confirm the presence of cointroduced mutations and for colocalization with various markers. PIK3CA and PPM1D are coexpressed in HA&lt;sup&gt;+&lt;/sup&gt; KPPMPIK tumor cells (left); ACVR1 and OLIG2 colocalize in H3.1KACVPIK tumors (middle, top); FGFR1 is upregulated in HA&lt;sup&gt;+&lt;/sup&gt; KNF tumor cells (middle, bottom); and PDGFRA is expressed in K27M&lt;sup&gt;+&lt;/sup&gt; KPP tumor cells (right). Scale bars, 50 μm. &lt;b&gt;D,&lt;/b&gt; Kaplan–Meier survival curves of IUE, tumor-bearing mice carrying different combinations of mutations. KPP (&lt;i&gt;n&lt;/i&gt; = 6), H3.1KACVPIK (&lt;i&gt;n&lt;/i&gt; = 13), KPPMPIK (&lt;i&gt;n&lt;/i&gt; = 22), and KNF (&lt;i&gt;n&lt;/i&gt; = 17). Statistical comparisons using the log-rank Mantel–Cox tests are described in Supplementary Table S2.&lt;/p&gt;
Respiratory‐induced 3D deformations of the renal arteries quantified with geometric modeling during inspiration and expiration breath‐holds of magnetic resonance angiography (2013)

The LRA and RRA deformed and translated significantly. Greater deformation of the LRA as compared to the RRA may be due to asymmetric anatomy and mechanical support by the inferior vena cava. The presented methodology can extend to quantification of deformation of diseased and stented arteries to help renal artery implant development.
Erratum: Wangerin et al. (2015) (2016)

Prior reports have suggested that delayed 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) oncology imaging can improve the contrast-to-noise ratio (CNR) for known lesions. Our goal was to estimaterealistic bounds for lesion detectability for static measurements within 1 to 4 hours between FDG injectionand image acquisition. Tumor and normal tissue kinetic model parameters were estimated from dynamic PETstudies of patients with early-stage breast cancer. These parameters were used to generate time-activitycurves (TACs) for up to 4 hours, for which we assumed both nonreversible and reversible models with differ-ent rates of FDG dephosphorylation (k4). For each pair of tumor and normal tissue TACs, 600 PET sinogramrealizations were generated, and images were reconstructed using the ordered subsets expectation maximi-zation reconstruction algorithm. Test statistics for each tumor and normal tissue region of interest were outputfrom the computer model observers and evaluated using a receiver operating characteristic analysis, with thecalculated area under the curve (AUC) providing a measure of lesion detectability. For the nonreversiblemodel (k4 = 0), the AUC increased in 11 of 23 (48%) patients for 1 to 2 hours after the current standardpostradiotracer injection imaging window of 1 hour. This improvement was driven by increased tumor/nor-mal tissue contrast before the impact of increased noise that resulted from radiotracer decay began to domi-nate the imaging signal. Ask4was increased from 0 to 0.01 min−1, the time of maximum detectabilityshifted earlier, due to decreasing FDG concentration in the tumor lowering the CNR. These results imply thatdelayed PET imaging may reveal inconspicuous lesions that otherwise would have gone undetected.
Anion Incorporation-induced Cage Deformation in 12CaO·7Al2O3 Crystal (2007)

Abstract Effects of O2− or OH− ion incorporation on the cage geometry in 12CaO·7Al2O3 (C12A7) crystals are examined by the maximum entropy method (MEM)/Rietveld analyses of synchrotron powder X-ray diffraction data. Presence of an extraframework anion in a cage causes inward displacements of two Ca2+ ions axially coordinating to the anion. The OH− ion locates at the cage center and induces smaller symmetric displacements of the two Ca2+ ions, while the O2− ion likely locates on off-axis positions and induces larger asymmetric Ca2+ ion displacements.
Supplementary Figure from Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer (2023)

Supplementary Figure from Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer
Spatial diffusion of heavy quarks in background magnetic field (2022)

The ratio of shear viscosity to entropy density shows a valley-shaped pattern well-known in the community of heavy-ion physics. Diffusion coefficients of heavy quark and meson shows the similar structure, and both sketches have become quite popular in the community. Present work has attempted a finite magnetic field extension of the diffusion coefficients of heavy quark and meson. Using Einstein's diffusion relation, we calculated heavy quark and heavy meson diffusion by the ratio of conductivity to susceptibility in the kinetic theory framework of relaxation time approximation. The relaxation time of heavy quark and meson are tuned from the knowledge of earlier works on spatial diffusion estimations, and then we have extended the framework for a finite magnetic field, where our outcomes have revealed two aspects - anisotropic and quantum aspects of diffusion with future possibilities of phenomenological signature.