MP22-17 PROSTATE ULTRASOUND TOMOGRAPHY (UT): CORRELATION WITH MRI AND WHOLE MOUNT HISTOPATHOLOGY (2021)

You have accessJournal of UrologyImaging/Radiology: Uroradiology II (MP22)1 Sep 2021MP22-17 PROSTATE ULTRASOUND TOMOGRAPHY (UT): CORRELATION WITH MRI AND WHOLE MOUNT HISTOPATHOLOGY Cheyenne Williams, Michael Daneshvar, Yixuan Wu, Jeunice Owens-Walton, Nitin Yerram, Patrick T. Gomella, Luke P. OConnor, Nabila Khondakar, Michael Ahdoot, Ayele Negussie, Sheng Xu, Baris Turkbey, Maria Merino, Emad Boctor, James Wiskin, Bradford Wood, and Peter Pinto Cheyenne WilliamsCheyenne Williams , Michael DaneshvarMichael Daneshvar , Yixuan WuYixuan Wu , Jeunice Owens-WaltonJeunice Owens-Walton , Nitin YerramNitin Yerram , Patrick T. GomellaPatrick T. Gomella , Luke P. OConnorLuke P. OConnor , Nabila KhondakarNabila Khondakar , Michael AhdootMichael Ahdoot , Ayele NegussieAyele Negussie , Sheng XuSheng Xu , Baris TurkbeyBaris Turkbey , Maria MerinoMaria Merino , Emad BoctorEmad Boctor , James WiskinJames Wiskin , Bradford WoodBradford Wood , and Peter PintoPeter Pinto View All Author Informationhttps://doi.org/10.1097/JU.0000000000002013.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: With recent developments, state-of-the-art ultrasound tomography (UT) is now able to provide submillimeter-resolution imaging for tissue characterization and malignancy detection. Compared to conventional pulse-echo ultrasound (US) imaging, UT provides quantitative US transmission that characterizes speed of sound and constructs speckle-free, refraction-corrected 360-degree-compounded reflection images. Given the success of UT for accurately diagnosing breast cancers in patterns consistent with MRI, we sought to define feasibility of UT for prostate cancer imaging. In this preliminary ex vivo study, UT and speed of sound are explored as potential novel opportunities to differentiate between benign and malignant prostate tissue. METHODS: Fresh whole prostates were immediately collected from patients undergoing radical prostatectomy for biopsy-confirmed prostate cancer. Within 30 minutes of extraction, each specimen was scanned in an echolucent, polyacrylamide gel phantom in the QT Ultrasound Breast Scanner. UT images were processed, then wholemount histopathology, pre-operative MRI, and UT images were manually segmented by expert genitourinary radiologists and pathologists, and all three modalities were then co-registered using both rigid and deformable elastic registration based on prostate boundaries and anatomic landmarks. Localization of lesions identified by pre-operative MRI and wholemount pathology was then correlated and mapped in 3 dimensions with tri-planar UT images. RESULTS: Thirty consecutive prostate specimens were scanned with UT. Multi-modality correlation, 3D elastic co-registration, and fusion display of MRI, wholemount histopathology and ex vivo UT reflection sequences (Figure 1) demonstrate co-localization of signal abnormalities on each modality where the pathology-proven Gleason 9 tumor is present. CONCLUSIONS: Development of hardware and software solutions to mechanically co-register a transrectal US with a trans-bladder US will enable translational steps towards assessment of narrow-angle ultrasound tomography for in vivo prostate imaging. Further data is required to validate, corroborate, and define performance metrics for this novel imaging approach applied to prostate cancer imaging. Source of Funding: The National Institute of Health (NIH) Medical Research Scholars Program, Foundation for the NIH, NIH Intramural Research Program © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e398-e398 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cheyenne Williams More articles by this author Michael Daneshvar More articles by this author Yixuan Wu More articles by this author Jeunice Owens-Walton More articles by this author Nitin Yerram More articles by this author Patrick T. Gomella More articles by this author Luke P. OConnor More articles by this author Nabila Khondakar More articles by this author Michael Ahdoot More articles by this author Ayele Negussie More articles by this author Sheng Xu More articles by this author Baris Turkbey More articles by this author Maria Merino More articles by this author Emad Boctor More articles by this author James Wiskin More articles by this author Bradford Wood More articles by this author Peter Pinto More articles by this author Expand All Advertisement PDF downloadLoading ...