gebhart/patrepeval huggingface dataset:
Bordism invariants of colored links and topologically protected tricolorings (2023)

We construct invariants of colored links using equivariant bordism groups of Conner and Floyd. We employ this bordism invariant to find the first examples of topological vortex knots, the knot structure of which is protected from decaying via topologically allowed local surgeries, i.e., by reconnections and strand crossings permitted by the topology of the vortex-supporting medium. Moreover, we show that, up to the aforementioned local surgeries, each tricolored link either decays into unlinked simple loops, or can be transformed into either a left-handed or a right-handed tricolored trefoil knot.
Material technology for 2.5D/3D package (2015)

Packaging material is one of the key components for through-silicon via (TSV) 2.5D/3D package giving a strong impact on the higher density integration and its reliability.
Figure S1 from α<sub>v</sub>β<sub>3</sub> Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin (2023)

&lt;p&gt;alphaV and beta1 in LNCaP transfectants&lt;/p&gt;
Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy (2018)

Purpose : Diabetic retinopathy (DR) is a leading complication of diabetes. It is thought that increased rod metabolism under dark adaptation exacerbates hypoxia in diabetic retina. Nowadays most treatments for DR are invasive and need multiple clinic visits. Recently a phototherapeutic contact lens has been designed to provide illumination to retina as a means to supress dark adaptation. It may be possible to delay the progression of DR. The purpose of this study is to explore the bioactivity and safety of this device.&#13;\nMethods : Six eyes from three healthy mature white New Zealand rabbits were used. The phototherapeutic contact lens was placed on treated eye. An non-phototherapeutic contact lens was used on the fellow eye as a control. To determine bioactivity of photoreceptors, an ERG was performed. Flash response, including amplitude and implicit time on scotopic condition were analyzed at different flash intensities (100, 300, 1000, 3000, 10000, 25000 mcd.s/m^2, respectively). Animals were under a 20-minutes period of dark adaption before any ERG. Then the contact lens were swapped on the eyes and the ERG were repeated. The whole process was performed in a dark room under dim red light. Once ERG were completed, the phototherapeutic contac lens was sutured to the eye for a long–term period (28 days) to verify safety. There will be a statistical analysis using Graph Pad Prism 7.0, determining the degree of correlation between the groups. Histological analysis will be performed to determine safety.&#13;\nResults : The ERG showed that both the amplitude and implicit time of b-wave in the treated eye were significantly shorter than the untreated eye under scotopic conditions (Figure 1). No significant difference in the amplitude and implicit time of a-wave was observed. A representative plot (Figure 2) shows significant depression of b-wave, both in the amplitude and implicit time (amplitude: p=0.01; implicit time: p&lt;0.001).&#13;\nConclusions : The phototherapeutic contact lens can effectively reduce the bioactivity of the retina, without ocular side effects in an acute follow-up. Further studies should be performed for a long-term placement in both healthy and retinal ischemic animal models to determine whether this device can reduce oxygen consumption in retina and delay disease progression. Long-term histology from contact lens safety is on going and will be presented.
Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomized Controlled Trial (2021)

F/TAF was safe and well-tolerated. TFV-DP concentrations were higher in PBMCs and similar or higher (4h post dose) in female genital tract tissues for F/TAF versus F/TDF. High FTC and FTC-TP concentrations in all compartments support the potential of F/TAF as a new PrEP combination for women.
Macromol. Chem. Phys. 22/2016 (2016)

Front Cover: Nanostructured aniline formaldehyde resin/polysilazane hybrid materials are produced by twin polymerization of 2,2′-spirobi[3,4-dihydro-1H-1,3,2-benzodiazasiline]. This is the first step to the formation of amorphous Si/C/N hybrid materials at higher temperatures. Further details can be found in the article by Lysann Kaβner, Anja Knoblauch, Andreas Seifert, Rolf-Egbert Grützner, Gerhard Cox, Arno Lange, Szilard Csihony, Frank Simon, Susann Anders, Lothar Kroll, Mahfujur Rahaman, Dietrich Zahn, Lutz Mertens, Marcus Weber, Michael Mehring, and Stefan Spange* on page 2462.
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives (2016)

The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these pumps important antibacterial drug discovery targets. We have recently developed novel pyranopyridine-based inhibitors of AcrB, which are orders of magnitude more powerful than the previously known inhibitors. However, further development of such inhibitors has been hindered by the lack of structural information for rational drug design. Although only the soluble, periplasmic part of AcrB binds and exports the ligands, the presence of the membrane-embedded domain in AcrB and its polyspecific binding behavior have made cocrystallization with drugs challenging. To overcome this obstacle, we have engineered and produced a soluble version of AcrB [AcrB periplasmic domain (AcrBper)], which is highly congruent in structure with the periplasmic part of the full-length protein, and is capable of binding substrates and potent inhibitors. Here, we describe the molecular basis for pyranopyridine-based inhibition of AcrB using a combination of cellular, X-ray crystallographic, and molecular dynamics (MD) simulations studies. The pyranopyridines bind within a phenylalanine-rich cage that branches from the deep binding pocket of AcrB, where they form extensive hydrophobic interactions. Moreover, the increasing potency of improved inhibitors correlates with the formation of a delicate protein- and water-mediated hydrogen bond network. These detailed insights provide a molecular platform for the development of novel combinational therapies using efflux pump inhibitors for combating multidrug resistant Gram-negative pathogens.
Depression in young adults (2003)

Depression, as a heterogeneous collection of disorders, is likely to include subgroups that are more genetic in origin. In common with other neuropsychiatric disorders such as schizophrenia, Alzheimer's disease and Huntington's disease, earlier age at onset in depression is associated with higher genetic loading and poorer long-term outcome. Adolescents and young adults with depression are also at high risk of developing a bipolar illness. This article reviews depressive illnesses that occur for the first time in adolescence and young adulthood. Case studies are used to discuss atypical presentations and the evolving concept of bipolar-spectrum disorders.
Silicon Carbide JFET Super-Cascodes for Normally-On Current Source Inverter Switches in Medium Voltage Variable Speed Electrostatic Drives (2019)

This work focuses on the design and testing of silicon carbide JFET super-cascodes for medium voltage electrostatic machine drives. These drives require medium voltage (7kV peak) and low current (<; 2A) normally-on switches that are not available as monolithic semiconductors. Characterization of the super-cascodes (12 JFETs in series) demonstrates normally-on (1Ω, Vgs = 0) behavior and high voltage blocking capabilities (100uA at 10kV). Using a clamped inductive load, two gate-coupling methods, one adding a fixed vs a stack position scaled capacitance, were tested to determine the best solution for a low-loss high-switching frequency device. The fixed capacitance had the lowest loss of 5.6mJ when tested at 7kV and 2 A. Six super-cascodes were then combined in a current source inverter operating at 4.5 kVrms line - line, 400 Hz fundamental with a switching frequency of 20kHz driving a 2.1 kVA RC load to emulate the electrostatic machine.
A Versatile Low Temperature Curing Molecular Silver Ink Platform for Printed Electronics (2018)

The development and sale of conductive silver flake-based inks remains one of the most profitable areas within the printed electronics (PE) industry. However, the volatility of the silver market is a concern for conductive ink manufacturers, so cost effective alternatives that can minimize the amount of metal used to produce a functional trace are actively being investigated and developed in order decrease costs. Here we present a simple formulation containing a silver compound that provides a screen printable ink capable of producing traces with thicknesses under 1 micometer, linewidths as narrow as 42 μm separated by 38 μm and excellent electrical properties (22 μΩ·cm) following thermal sintering at temperatures of 120 °C on PET substrates. The molecular ink is also quite versatile, enabling the metallization of common textile threads and allowing their incorporation into applications where the threads can serve as wires to power LEDs driven by a wearable electronic platform. The silver traces derived from the silver ink also demonstrate impressive stretchability on both metalized latex/polyester threads and as printed traces on thermoplastic polyurethane (TPU) substrates, where the threads/traces remain conductive up to strains as high as 126%. The ability for the traces produced from the silver molecular ink to maintain conductivity as they are strained/stretched also enables their incorporation into structural and in-mold electronics applications, where conductive 3D traces can be produced through a simple thermoforming process. Together these results represent a significant advance for the PE industry.
Upconversion from aqueous phase lanthanide chelates (2005)

We have prepared and characterized several lanthanide ion complexes of multidentate ligands or chelates in an effort to develop new upconverting luminescent labels that can be immune to autofluorescence and photobleaching. This study has involved the characterization of various chelates of Nd, Er, and Tm with respect to relative luminescent efficiency and excited-state lifetimes and explored various two-photon stepwise excitation mechanisms. Using peak laser powers near 100 kW, the upconversion emissions of Nd in Nd(EDTA)2(5-) at 386 nm, Er in Er(DPA)3(3-) at 550 nm, and Tm in Tm(DPA)3(3-) at 480 nm, at levels of approximately 10(-12) moles can be detected.
TACH101, a first-in-class pan-inhibitor of KDM4 for treatment of gastrointestinal cancers. (2022)

132 Background: TACH101 is a novel, potent small molecule inhibitor of KDM4, a novel epigenetic target for cancer therapy. KDM4 is a family of histone lysine demethylases that, when overexpressed, drives key processes linked to cancer. Validation of KDM4 as a driver gene was confirmed across gastrointestinal tumor types including esophageal, colon and gastric cancers, and is associated with formation of aggressive tumors. Methods: TACH101 was evaluated in in vitro and in vivo studies including cell inhibition assays, patient-derived xenograft (PDX) and organoid models, and bioinformatics analyses studies. Results: In vitro, TACH101 treatment potently inhibited cell proliferation in cell lines and organoid models representing esophageal, CRC, and gastric cancers. TACH101 induced apoptosis in human CRC (HT-29) and esophageal (KYSE-150) cancer cell lines (EC50s 0.033 - 0.092 µM). Further evaluation using a panel of &gt; 300 cell lines from different tumor types showed potent activity of TACH101 against gastric cancer and CRC. In gastric cancer, 2D cell viability inhibition assays conducted on a panel of 11 gastric cancer cell lines showed 9/11 (82%) were sensitive to TACH101 treatment (IC50 0.004 - 0.072 µM); in PDX models, 4/5 (80%) were sensitive to TACH101 treatment (IC50 0.007 - 0.039 µM). In CRC, bioinformatics analysis indicated increased TACH101 sensitivity in cell lines with MSI-H status (IC50 1-150 nM). Sensitivity of MSI-H CRC to TACH101 was further confirmed in a panel of 14 CRC PDX models and 7 CRC organoid models in culture-based viability inhibition assays. In PDX models, 5/5 (100%) characterized as MSI were sensitive to TACH101 treatment (IC50 0.001 - 0.014 µM), whereas 4/8 (50%) characterized as MSS were sensitive to TACH101 (IC50 0.003 - 0.270 µM). In patient derived CRC organoid models, 3/3 (100%) characterized as MSI were sensitive to TACH101 treatment (IC50 0.022 - 0.149 µM) whereas 0/3 (0%) characterized as MSS were sensitive (IC50 &gt; 10 µM). In vivo, TACH101 triggered effective tumor control (≥70%) in xenograft models of CRC (SU60), esophageal (KYSE-150) and gastric (GXA-3036) cancers. Pharmacologic studies showed TACH101 demonstrated favorable cell permeability, good oral bioavailability, and high metabolic stability. Conclusions: Preclinical work on TACH101 KDM4 inhibitor demonstrates compelling data and applicability as a potential therapy for gastrointestinal cancers. Preparations to advance TACH101 into clinical trials are underway.
On the capacity of cellular CDMA with successive decoding and controlled power disparities (2002)

In a cellular CDMA system, the received powers from mobiles that are close to the base station form a dominant factor in the interference presented to mobiles that are farther away. Conventional power control techniques try to eliminate this problem by maintaining equal received powers for all users. However, recent research has produced successive interference cancellation schemes that rely on controlled disparities between the powers of users. In this work, we study capacity gains in cellular CDMA from ideal successive decoding. Our studies show that successive decoding with power control enforcing appropriately disparate powers can approximately double the capacity when compared with a conventional system using single user decoding. The idea of disparities among users also appears naturally when different users transmit at different rates. We study the capacity regions for the multi-rate case and find that successive decoding provides even larger capacity gains over single user decoding in this case.
Search for vector-like T quarks decaying to top quarks and Higgs bosons in the all-hadronic channel using jet substructure (2015)

A search is performed for a vector-like heavy T quark that is produced in pairs and that decays to a top quark and a Higgs boson. The data analysed correspond to an integrated luminosity of 19.7 fb -1 collected with the CMS detector in proton-proton collisions at s = 8 TeV. For T quarks with large mass values the top quarks and Higgs bosons can have significant Lorentz boosts, so that their individual decay products often overlap and merge. Methods are applied to resolve the substructure of such merged jets. Upper limits on the production cross section of a T quark with mass between 500 and 1000 GeV/c 2 are derived. If the T quark decays exclusively to tH, the observed (expected) lower limit on the mass of the T quark is 745 (773) GeV/c 2 at 95% confidence level. For the first time an algorithm is used for tagging boosted Higgs bosons that is based on a combination of jet substructure information and b tagging.
Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis—Reply (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutations in theAryl Hydrocarbon Receptor Interacting ProteinGene Are Not Highly Prevalent among Subjects with Sporadic Pituitary Adenomas (2007)

AIP mutations do not appear to play a prominent role in sporadic pituitary tumorigenesis in this population of European subjects.
Steerable media (2001)

Article Steerable media: interactive television via video synthesis Share on Authors: Chris Marrin Sony Electronics Distributed Systems Lab Sony Electronics Distributed Systems LabView Profile , Rob Myers Sony Electronics Distributed Systems Lab Sony Electronics Distributed Systems LabView Profile , Jim Kent Sony Electronics Distributed Systems Lab Sony Electronics Distributed Systems LabView Profile , Peter Broadwell Sony Electronics Distributed Systems Lab Sony Electronics Distributed Systems LabView Profile Authors Info & Claims Web3D '01: Proceedings of the sixth international conference on 3D Web technologyFebruary 2001 Pages 7–14https://doi.org/10.1145/363361.363365Online:01 February 2001Publication History 8citation695DownloadsMetricsTotal Citations8Total Downloads695Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Characterization of the Friction Coefficient of Aluminum Alloy 6061 in Ultra-Precision Machining (2020)

Aluminum alloy 6061(Al6061), an Al-Mg-Si alloy, is a precipitation-hardened alloy. The generation of precipitate affects its mechanical properties, and induces a worse surface finish during diamond cutting. The friction coefficients of the tool-chip and tool-workpiece interfaces influence temperature rise, and are therefore important predictors of tool wear and surface integrity during the diamond cutting of Al6061. This study investigated the relationship between precipitate generation and the friction coefficients of Al6061. Groups of experiments were conducted to study the influence of temperature and heating time on the number of precipitates and the friction coefficients. The results show that the generation of AlFeSi particles induces cracks, scratch marks and pits on diamond-machined Al6061 and affects the cutting forces. Moreover, the variation trend of the friction coefficient of Al6061 under different heating conditions agrees well with that of the number of AlFeSi particles. This implies that, during ultra-precision machining of precipitation-hardened alloys, cutting-induced heat causes precipitates to form on the chips and machined surface, changing their material properties. This affects the tool-workpiece and tool–chip contact conditions and the mechanisms of chip formation and surface generation in ultra-precision machining.
Binary time-frame expansion [circuit verification] (2003)

This paper introduces a new method for performing time-frame expansion based on writing the number of time frames in terms of powers of two. In the proposed method, the behavior of a circuit for t time frames, where 0/spl les/t<n is modeled by unrolling the circuit 2/sup 0/, 2/sup 1/, 2/sup 2/,...,2/sup (log n-1)/ times and combining them. This formulation of the problem makes it possible to prune the search space quickly when the problem is infeasible. To show the advantage of this method, we have used it to model the state justification problem and solve the problem using a SAT-solver. Experimental results show several orders of magnitude speedup for some non-trivial infeasible problems. Furthermore, in most cases the CPU time requirement grows linearly in terms of the number of time frames.
Safety, Efficacy, and Durability of Carotid Artery Stenting for Restenosis following Carotid Endarterectomy: A Multicenter Study (2000)

Carotid artery stenting can be performed in patients with restenosis following carotid endarterectomy with 30-day complication rates comparable to those of most published studies on repeat carotid endarterectomy. Results of late follow-up suggest that this technique is durable and efficacious.
Randomized instruction set emulation to disrupt binary code injection attacks (2003)

Binary code injection into an executing program is a common form of attack. Most current defenses against this form of attack use a 'guard all doors' strategy, trying to block the avenues by which execution can be diverted. We describe a complementary method of protection, which disrupts foreign code execution regardless of how the code is injected. A unique and private machine instruction set for each executing program would make it difficult for an outsider to design binary attack code against that program and impossible to use the same binary attack code against multiple machines. As a proof of concept, we describe a randomized instruction set emulator (RISE), based on the open-source Valgrind x86-to-x86 binary translator. The prototype disrupts binary code injection attacks against a program without requiring its recompilation, linking, or access to source code. The paper describes the RISE implementation and its limitations, gives evidence demonstrating that RISE defeats common attacks, considers how the dense x86 instruction set affects the method, and discusses potential extensions of the idea.
Tin-119m Moessbauer and x-ray photoelectron (ESCA) studies of tin oxidation state and bonding in base-dialkyltin pentacarbonylchromium and tetracarbonyliron complexes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTin-119m Moessbauer and x-ray photoelectron (ESCA) studies of tin oxidation state and bonding in base-dialkyltin pentacarbonylchromium and tetracarbonyliron complexesG. W. Grynkewich, B. Y. K. Ho, T. J. Marks, D. L. Tomaja, and J. J. ZuckermanCite this: Inorg. Chem. 1973, 12, 11, 2522–2525Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/ic50129a007https://doi.org/10.1021/ic50129a007research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts