gebhart/patrepeval huggingface dataset:
EBEACOPP WITH OR WITHOUT RITUXIMAB IN INTERIM‐PET‐POSITIVE ADVANCED‐STAGE HODGKIN LYMPHOMA: UPDATED RESULTS OF THE INTERNATIONAL, RANDOMIZED PHASE 3 GHSG HD18 TRIAL (2017)

Introduction: FDG-PET (PET-2) after 2 cycles of eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) might be an appropriate tool to guide treatment and predict outcome in patients with advanced-stage HL. In the HD18 trial, we hypothesized that the addition of rituximab to 8 cycles of eBEACOPP could improve the presumably poor progression-free survival (PFS) of PET-2 positive patients. An interim analysis with a median follow-up of 3 years did not show any benefit of this combined immuno-chemotherapy. Here, we report updated results with longer follow-up and the outcome of subsequently enrolled PET-2 positive patients treated with only 6 cycles of eBEACOPP. Methods: Between May 2008 and July 2014 we recruited patients with newly diagnosed, advanced-stage HL aged 18–60 years. PET-2 was centrally assessed with FDG uptake higher than the mediastinal blood pool defined as positive. Patients with positive PET-2 were randomly assigned to receive six additional cycles of either eBEACOPP or eBEACOPP plus rituximab (R-eBEACOPP). PET-positive residues ≥2.5 cm after chemotherapy were irradiated. As result of the previous HD15 study, standard treatment was changed from 8 to 6 cycles in June 2011 and randomization after positive PET-2 was stopped. From there on, all PET-2 positive patients received 6 cycles of eBEACOPP. Results: We enrolled 2,101 patients. 434 patients with positive PET-2 were randomly assigned to either eBEACOPP (n = 217) or R-eBEACOPP (n = 217), another 506 PET2-positive patients were assigned to standard treatment with 6xeBEACOPP after June 2011. With a median follow-up of 66 months, estimated 5-year PFS for the randomized comparison was 89.7% (95% CI 85.4–94.0) with 8xeBEACOPP and 88.1% (83.5–92.7) with 8xR-eBEACOPP (log-rank p = 0.5). 9 patients (4%) in the 8xeBEACOPP group and 14 (6%) in the 8xR-eBEACOPP group had died; estimated 5-year overall survival was 96.4% (93.8–99.0) with 8xeBEACOPP and 93.9% (90.6–97.3) with 8xR-eBEACOPP (log-rank p = 0.3). In patients recruited after June 2011, the estimated 3-year PFS was 92.0% (95% CI 89.3–94.6, median follow-up 36 months) and 3-year overall survival was 98.0% (95% CI 96.7–99.3, median follow-up 37 months) with 6xeBEACOPP. Conclusions: Updated results confirm that the addition of rituximab to eBEACOPP does not improve the PFS of patients with advanced-stage HL. Importantly, PFS for patients with positive PET-2 is much better than expected and comparable to PET-2-unselected patients treated with eBEACOPP. Thus, PET-2 cannot identify patients at risk for treatment failure in this setting. Importantly, our current analysis shows that this also holds true with the reduced treatment intensity of only 6 cycles of eBEACOPP. We conclude that the high efficacy of the GHSG standard therapy for advanced-stage HL overrides the positive predictive value of PET-2. Keywords: BEACOPP; Hodgkin lymphoma (HL); rituximab.
Evaluation of the flexion gap by axial radiography of the distal femur (2006)

The shape of the flexion gap in 20 normal knees was evaluated by axial radiography of the distal femur, and the results compared with those obtained in a previous study by MRI. The observed asymmetry was reduced by 29% using radiography, with a mean value of 3.6 degrees (1.5 degrees to 6.3 degrees) compared with that obtained by MRI of 5.1 degrees (2.6 degrees to 9.5 degrees), a mean discrepancy of 1.49 degrees. The results obtained by radiography and MRI showed a strong correlation (r = 0.78). Axial radiography is acceptable for the evaluation of the flexion gap and is less expensive and more comfortable to perform than MRI. Additionally, no metallic artefact occurs when the radiological method is used for assessment after arthroplasty.
Ruthenium catalyzed oxidation of tertiary nitrogen compounds with molecular oxygen: an easy access to N-oxides under mild conditions (2002)

A variety of tertiary nitrogen compounds have been efficiently oxidized to their corresponding N-oxides in excellent yields with molecular oxygen as a sole oxidant and ruthenium trichloride as catalyst.
Virologic Suppression Measured by a Cytomegalovirus (CMV) DNA Test Calibrated to the World Health Organization International Standard Is Predictive of CMV Disease Resolution in Transplant Recipients (2013)

NCT00431353.
Chemotherapeutic Effects of Acridine Derivatives (2004)

Acridine derivatives show a broad range of biological activities. They have primarily been explored as chemotherapeutic agents (anticancer, antibacterial, antiprotozoal), because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase and telomerase enzymes. Research continues to be focussed primarily in these areas, but recent work shows they are active also as anticholinesterase agents. Keywords: acridine, antibacterial, anticancer, antiprotozoal, anticholinesterase, telomerase
Abstract 17917: Novel Techniques for the Diagnosis of Acute Myocarditis: A Clinical Cardiovascular Magnetic Resonance Study (2012)

Background: CMR is well-established in the diagnosis of myocarditis, typically including dark-blood T2-weighted (T2W) imaging, early and late gadolinium imaging. Novel CMR techniques are now available, including bright-blood T2W-CMR, and T1-mapping which is also sensitive to changes in free water content. We hypothesized that these emerging methods can serve as new diagnostic criteria for myocarditis. Methods & Results: We studied 34 patients with suspected acute myocarditis according to the Lake Louise Criteria and 45 controls. CMR (1.5T) within 12 days included (1) dark-blood T2 (STIR); (2) bright-blood T2 (ACUT2E); (3) T1-mapping (ShMOLLI); and (4) late gadolinium enhancement (LGE) (Fig 1). Image analysis was performed for (1) global myocardial T2 signal intensity (SI) ratio against skeletal muscle; (2) mean myocardial T1; (3) LGE. All patients had a CMR diagnosis of myocarditis, including positive T2-STIR and typical LGE pattern. Patient global myocardial T2 SI ratios by both dark-blood (1.81±0.28 vs 1.58±0.16, p Conclusions: Bright-blood T2W-CMR and T1-mapping detect acute myocarditis with good diagnostic accuracy. Non-contrast T1-mapping showed superior diagnostic performance compared to conventional dark-blood and newer bright-blood T2W-CMR.
Search for CP violation in the decays D+ → KSπ+ and D+ → KSK+ (2002)

A high-statistics sample of photoproduced charm from the FOCUS experiment has been used to search for direct CP violation in the decay rates for D → K S π + and D + → K S K + . We have measured the following asymmetry parameters relative to D + → K - π + π + : A C P (K S π + ) = (-1.6 ′ 1.5 ′ 0.9)%, A C P (K S K + ) = (+6.9 ′ 6.0 ′ 1.5)%, and A C P (K S K + ) = (+7.1 ′ 6.1 ′ 1.2)% relative to D + → K S π + . We have also measured the relative branching ratios and found Γ(D + + K 0 π + )/Γ(D + → K π + π + ) = (30.60 ′ 0.46 ′ 0.32)%, Γ(D + → K 0 K + )/Γ(D + → K - π + π + ) = (6.04 ′ 0.35 ′ 0.30)%, and Γ(D + → K 0 K + )/Γ(D + → K 0 π + ) = (19.96 ′ 1.19 ′ 0.96)%.
Liquid crystalline side chain-coil diblock copolymers by living free radical polymerization (1999)

A series of LC-coil diblock copolymers was prepared using living radical polymerization. The resulting polymers were shown to possess a smectic mesophase and a lamellar microstructure by X-ray diffraction. The microstructure slowly develops on annealing as suggested by DSC studies.
Radiative and Nonradiative Exciton Lifetimes in GaN Grown by Molecular Beam Epitaxy (2001)

GaN epilayers grown by molecular-beam epitaxy (MBE) have been studied by temperature dependent time-resolved photoluminescence (PL). The PL decay times for free excitons and donor-bound excitons as well as the quantum efficiency have been measured for different temperatures. Radiative and nonradiative lifetimes have been evaluated from experimental values for the quantum efficiency and the PL decay time, assuming fully radiative processes at 2 K. The so obtained temperature dependence for the radiative lifetime cannot be described by a simple T3/2 law for the whole temperature range. The temperature behavior of radiative lifetimes suggests the presence of a strong nonradiative recombination channel even at very low temperatures.
Energy Efficient Causal Packet Scheduling in Wireless Fading Channels with Hard Delay Constraints (2010)

In this paper we study the problem of energy efficient packet scheduling in wireless fading channels with hard delay constraints. Each packet has a strict delay constraint of D time slots and it has to be delivered before its delay deadline. Optimal scheduling of each packet now depends on future Channel State Information (CSI) which is not available. We develop the upper and lower bounds on the optimal output rate and develop a two step solution. In the first step we solve the relaxed optimization problem without bounds by using Lagrange Optimization theory and obtain an initial output rate. In the second step this output rate is adjusted such that the deadlines are successfully achieved. Simulation results show good performance in terms of energy efficiency.
ChemInform Abstract: Sweet (Hetero)aromatics: Glycosylated Templated for the Construction of Saccharide Mimetics. (2011)

Abstract Several general strategies for the construction of mono‐ and diglycosylated (hetero)aromatics as potential metabolically stable oligosaccharides are described.
A Novel Targeted Analysis of Peripheral Steroids by Ultra-Performance Supercritical Fluid Chromatography Hyphenated to Tandem Mass Spectrometry (2018)

Ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS) is an alternative method for steroid analysis. Continuous development of analytical methodologies for steroid profiling is of major importance in the clinical environment to provide useful and more comprehensive data. The aim of this study was to identify and quantify a large number of endogenous steroids from the four major classes (estrogens, androgens, progestogens and corticosteroids) simultaneously within a short analytical time. This novel UPSFC-MS/MS method with electrospray in positive ionisation (ESI+) mode is robust, selective and present sufficiently high sensitivity to profile nineteen steroids in 50 µL human plasma. Under optimised conditions, nineteen different steroids were separated with high efficiency in the multiple reaction monitoring (MRM) mode. The linearity of the method was good with correlation coefficients (R<sup>2</sup>) in the range of 0.9983-0.9999 and with calibration range from 0.05-500 ng/mL in human plasma. The intraday and interday precision of the method, as RSD, was less than 15%. The accuracy of the nineteen analytes varied between 80 to 116%. Finally, the novel method was successfully applied for the determination of nineteen steroids within 5 minutes providing the possibility to use it for research as well as routine healthcare practice.
Data from Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Recently, we showed that intratumoral delivery of low-dose, immunostimulatory CpG oligodeoxynucleotides conjugated with carbon nanotubes (CNT-CpG) was more effective than free CpG and not only eradicated intracranial (i.c.) gliomas but also induced antitumor immunity that protected mice from subsequent i.c. or systemic tumor rechallenge. Here, we examined whether the same “intracerebral immunotherapy” strategy could be applied to the treatment of metastatic brain tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Mice with both i.c. and s.c. melanomas were injected intratumorally with CNT-CpG into either location. Antitumor responses were assessed by flow cytometry, bioluminescent imaging, and animal survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; When given s.c., CNT-CpG response was mostly local, and it only modestly inhibited the growth of i.c. melanomas. However, i.c. CNT-CpG abrogated the growth of not only brain but also s.c. tumors. Furthermore, compared with s.c. injections, i.c. CNT-CpG elicited a stronger inflammatory response that resulted in more potent antitumor cytotoxicity and improved &lt;i&gt;in vivo&lt;/i&gt; trafficking of effector cells into both i.c. and s.c. tumors. To investigate factors that accounted for these observations, CNT-CpG biodistribution and cellular inflammatory responses were examined in both tumor locations. Intracranial melanomas retained the CNT-CpG particles longer and were infiltrated by Toll-like receptor (TLR-9)–positive microglia. In contrast, myeloid-derived suppressive cells were more abundant in s.c. tumors. Although depletion of these cells before s.c. CNT-CpG therapy enhanced its cytotoxic responses, antitumor responses to brain melanomas were unchanged.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings suggest that intracerebral CNT-CpG immunotherapy is more effective than systemic therapy in generating antitumor responses that target both brain and systemic melanomas. &lt;i&gt;Clin Cancer Res; 18(20); 5628–38. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Esterification of glycerol from biodiesel production to glycerol carbonate in non-catalytic supercritical dimethyl carbonate (2016)

Conversion of glycerol from biodiesel production to glycerol carbonate was studied by esterification with dimethyl carbonate in a non-catalytic supercritical condition. It was found that in a non-catalytic supercritical condition, glycerol at higher purity gave higher yield of glycerol carbonate at 98 wt% after reaction at 300 °C/20-40 MPa/15 min. The yield of glycerol carbonate was observed to increase with molar ratio, temperature, pressure and time until a certain equilibrium limit. The existence of impurities such as water and remnants of alkaline catalyst in crude glycerol will direct the reaction to produce glycidol. Although impurities might not be desirable, the non-catalytic supercritical dimethyl carbonate could be an alternative method for conversion of glycerol from biodiesel production to value-added glycerol carbonate.Graphical abstractPlausible reaction scheme for conversion of glycerol to glycerol carbonate in non-catalytic supercritical dimethyl carbonate.
Design and characterization of an electromagnetic probe for distinguishing morphological differences in soft tissues (2018)

We present a method for designing and optimizing an in-house designed electromagnetic probe for distinguishing morphological differences in biological tissues. The probe comprises concentric multi-wound coils, the inner being the primary coil and the outer being the detector coil. A time-varying voltage is imposed on the primary coil, resulting in an induced current in the detector coil. For highly conductive samples, eddy currents are induced in the sample and inductively couple with the electromagnetic probe. However, in weakly conducting samples, the primary coupling mechanism is found to be capacitive though there can be a non-negligible inductive component. Both the mutual inductive coupling and the capacitive coupling between the sample and the probe are detected as a change in the induced voltage of the detector coil using lock-in detection. The induced voltage in the detector coil is influenced more by the morphological structure of the specimen rather than by changes in electrical conductivity within different regions of the sample. The instrument response of the lock-in amplifier is also examined with simulated input voltage signals to relate its output to specific changes in inductive and capacitive coupling, in order to relate sample characteristics to a single voltage output. A circuit element model is used to interpret the experimental measurements. It is found that the sensitivity of the measurement for a given set of probe characteristics (resistances, inductances, and capacitances) can be optimized by adding a small amount of capacitance in the external circuit in parallel with the detector coil. Illustrative measurements are presented on animal (porcine and bovine) tissue and on human liver tissue containing a metastatic tumor to demonstrate the capabilities of the probe and measurement method in distinguishing different tissue types despite having similar electrical conductivities. Since biological tissues are multi-scale, heterogeneous materials comprising regions of differing conductivity, permittivity, and morphological structure, the electromagnetic method presented here has the potential to examine structural variations in tissue undergoing physical changes due to healing or disease.
Development of a Three-Dimensional Mechanical Gravity Canceller for High-Performance Manipulators (2002)

本研究では, マニピュレータ運動性能(加速度, 速度, 動作範囲, 姿勢)の大幅な向上を実現する本質的な解決策としての機構開発を目的とする。従来, その手法として自重補償の効果が特に大きいことから, カウンターバランスやばねー平行リンク機構などが提案されてきた。しかし, いずれも総重量, 補償精度, 可動領域, 自由度数という点で課題が残されていた。そこで本報告では, これらを解決する新しい機械的3次元自重補償機構を開発し, これを備えた4自由度マニピュレータによる検証実験にて本機構の運動性能向上に対する有効性を示す。
Improvement in the stability of phosphorescent OLED with solution-coated hole-transport layer via exciplex–triplet energy transfer (2021)

An approach to enhance the lifetime of a phosphorescent organic light-emitting diode (PHOLED) with a solutionprocessed hole-transport layer (HTL) by employing energy transfer from an exciplex to a phosphorescent emitter is presented. Using the structure of solution-coated Poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(4,4′-(N-(4-secbutylphenyl) diphenylamine)] (TFB) as a HTL and vacuum-deposited 4,4′-Bis(carbazol-9-yl)biphenyl (CBP) as a host provides a suitable situation for the formation of exciplex between CBP and TFB because energy gap between the LUMO level of CBP and the HOMO level of TFB becomes much smaller than the HOMO-LUMO gap of CBP or TFB. As the PHOLED emission is solely from the phosphorescence, the intermediate exciplex state rapidly transfers its energy to the dopant triplet. Since singlet-excited state of exciplex requires much lower energy than singlet-excited state of the host, driving voltage for PHOLEDs using exciplex–triplet energy transfer (ExTET) is lower than conventional, leading to longer device lifetime. The results show that the electroluminescence half-life (LT50) of fabricated device with the structure of HTL TFB and host CBP in which exciplex can form between CBP and TFB is about 5785 h (for an initial luminance of 1000 cd m−2). On the other hand, in the other fabricated devices with the same structure and just mixing TFB with other materials with deeper HOMO level, where the ability to form exciplex between TFB and CBP is suppressed, the device lifetime is significantly shorter. To the best of our knowledge, it is the first time that ExTET is obtained in a hybrid structure involving solution-coated and vacuum-deposited layers.
Multicore optical fiber and connectors for short reach, high density links (2012)

Adoption of multicore fibers will accelerate in high bandwidth density applications in next generation data centers once multicore connectors, transceiver coupling elements, cabling and other components are available to complement transceivers in end-to-end optical interconnects.
qPCRTag Analysis - A High Throughput, Real Time PCR Assay for Sc2.0 Genotyping (2015)

The Synthetic Yeast Genome Project (Sc2.0) aims to build 16 designer yeast chromosomes and combine them into a single yeast cell. To date one synthetic chromosome, synIII1, and one synthetic chromosome arm, synIXR2, have been constructed and their in vivo function validated in the absence of the corresponding wild type chromosomes. An important design feature of Sc2.0 chromosomes is the introduction of PCRTags, which are short, re-coded sequences within open reading frames (ORFs) that enable differentiation of synthetic chromosomes from their wild type counterparts. PCRTag primers anneal selectively to either synthetic or wild type chromosomes and the presence/absence of each type of DNA can be tested using a simple PCR assay. The standard readout of the PCRTag assay is to assess presence/absence of amplicons by agarose gel electrophoresis. However, with an average PCRTag amplicon density of one per 1.5 kb and a genome size of ~12 Mb, the completed Sc2.0 genome will encode roughly 8,000 PCRTags. To improve throughput, we have developed a real time PCR-based detection assay for PCRTag genotyping that we call qPCRTag analysis. The workflow specifies 500 nl reactions in a 1,536 multiwell plate, allowing us to test up to 768 PCRTags with both synthetic and wild type primer pairs in a single experiment.
High-power frequency comb at 2  μm wavelength emitted by a Tm-doped fiber laser system (2018)

We report on the generation of a high-power frequency comb in the 2 μm wavelength regime featuring high amplitude and phase stability with unprecedented laser parameters, combining 60 W of average power with <30 fs pulse duration. The key components of the system are a mode-locked Er:fiber laser, a coherence-preserving nonlinear broadening stage, and a high-power Tm-doped fiber chirped-pulse amplifier with subsequent nonlinear self-compression of the pulses. Phase locking of the system resulted in a phase noise of less than 320 mrad measured within the 10 Hz-30 MHz band and 30 mrad in the band from 10 Hz to 1 MHz.
Chemistry of nitrenium ions. XXVI. Neighboring group participation by bridgehead nitrogen in bridged polycyclic systems (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of nitrenium ions. XXVI. Neighboring group participation by bridgehead nitrogen in bridged polycyclic systemsPaul G. Gassman, Richard L. Cryberg, and Koichi ShudoCite this: J. Am. Chem. Soc. 1972, 94, 21, 7600–7602Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/ja00776a067https://doi.org/10.1021/ja00776a067research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In-situ Diagnostic for Assessing Hall Thruster Wear (2018)

The design of a new diagnostic to measure the net erosion of Hall thruster surfaces is presented. This diagnostic consists of a pair of optical non-contact profilometer pens mounted to a set of motion stages, which can interrogate the surface features of multiple components of interest including the hollow cathode assembly, magnet front pole covers, and discharge channel. By comparing scans of these surfaces to reference features, estimates of the component erosion rates can be acquired throughout long-duration lifetime tests without venting and removing the thruster from the vacuum facility for external profilometry. This work presents a detailed overview of the diagnostic design including the precision positioning system. In addition, preliminary data are shown which verify diagnostic operation and establish a baseline that will be used to track the erosion of the Hall Effect Rocket with Magnetic Shielding (HERMeS) Technology Demonstration Unit 3 (TDU-3) during an ongoing long-duration wear test.