gebhart/patrepeval huggingface dataset:
Systematic dynamic memory management design methodology for reduced memory footprint (2006)

New portable consumer embedded devices must execute multimedia and wireless network applications that demand extensive memory footprint. Moreover, they must heavily rely on Dynamic Memory (DM) due to the unpredictability of the input data (e.g., 3D streams features) and system behavior (e.g., number of applications running concurrently defined by the user). Within this context, consistent design methodologies that can tackle efficiently the complex DM behavior of these multimedia and network applications are in great need. In this article, we present a new methodology that allows to design custom DM management mechanisms with a reduced memory footprint for such kind of dynamic applications. First, our methodology describes the large design space of DM management decisions for multimedia and wireless network applications. Then, we propose a suitable way to traverse the aforementioned design space and construct custom DM managers that minimize the DM used by these highly dynamic applications. As a result, our methodology achieves improvements of memory footprint by 60% on average in real case studies over the current state-of-the-art DM managers used for these types of dynamic applications.
Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood–Brain Barrier (2013)

Enhanced platelet-derived growth factor (PDGF) signaling in glioma drives its development and progression. In this study, we define a unique role for stroma-derived PDGF signaling in maintaining tumor homeostasis within the glioma microenvironment. Large numbers of PDGF receptor-α (PDGFRα)-expressing stromal cells derived from oligodendrocytes progenitor cells (OPC) were discovered at the invasive front of high-grade gliomas, in which they exhibited a unique perivascular distribution. In PDGFRα-deficient host mice, in which orthotopic Gl261 tumors displayed reduced outgrowth, we found that tumor-associated blood vessels displayed smaller lumens and normalized vascular morphology, with tumors in host animals injected with the vascular imaging agent gadolinium also being enhanced less avidly by MRI. Notably, glioma-associated OPC promoted endothelial sprouting and tubule formation, in part by abrogating the inhibitory effect that perivascular astrocytes exert on vascular endothelial conjunctions. Stromal-derived PDGF-CC was crucial for the recruitment and activation of OPC, insofar as mice genetically deficient in PDGF-CC phenocopied the glioma/vascular defects observed in PDGFRα-deficient mice. Clinically, we showed that higher levels of PDGF-CC in glioma specimens were associated with more rapid disease recurrence and poorer overall survival. Our findings define a PDGFRα/PDGF-CC signaling axis within the glioma stromal microenvironment that contributes to vascular remodeling and aberrant tumor angiogenesis in the brain.
Mapping functions for successive interference cancellation in CDMA (2002)

Cancellation schemes for CDMA detection are based on estimating and removing the inherent multiple access interference. Several strategies for estimating the interference have been suggested, In this paper, we consider successive cancellation based on linear soft-decision, hard-decision, and clipped soft-decision. The influence of the cancellation function on the corresponding decision boundaries is discussed and qualitative statements regarding BER performance is made. BER performance based on computer simulations are presented and the "optimal" choice of the parameters for the clipped soft-decision is considered.
Synthesis of 3-Substituted-4(3H)-quinazolinones via HATU-Mediated Coupling of 4-Hydroxyquinazolines with Amines (2009)

A novel synthesis of 3-substituted 4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed. Under mild reaction conditions, the products were achieved in good yield from commercially available starting materials.
Unique prospects of phase change material Sb2Se3 for ultra-compact reconfigurable nanophotonic devices (2021)

In this work, we explore inverse designed reconfigurable digital metamaterial structures based on phase change material Sb 2 Se 3 for efficient and compact integrated nanophotonics. An exemplary design of a 1 × 2 optical switch consisting of a 3 µm x 3 µm pixelated domain is demonstrated. We show that: (i) direct optimization of a domain containing only Si and Sb 2 Se 3 pixels does not lead to a high extinction ratio between output ports in the amorphous state, which is owed to the small index contrast between Si and Sb 2 Se 3 in such a state. As a result, (ii) topology optimization, e.g., the addition of air pixels, is required to provide an initial asymmetry that aids the amorphous state's response. Furthermore, (iii) the combination of low loss and high refractive index change in Sb 2 Se 3 , which is unique among all phase change materials in the telecommunications 1550 nm band, translates into an excellent projected performance; the optimized device structure exhibits a low insertion loss (∼1.5 dB) and high extinction ratio (&gt;18 dB) for both phase states.
全谷物摄入对炎症影响的新进展 (2020)

(whole grain, WG) ，。 ，。， WGs ，、 。， 。 WGs ， 、WGs WGs 。.
Impact of consumers' diet choices on greenhouse gas emissions (2009)

This study explores the impacts on agricultural and total GHG emissions of Finnish consumption if the share of animal based food products was reduced and if the share of ecologically produced food was to increase in Finland. GHG emissions associated with production of basic food items were quantified (per capita per annum) for current food consumption, for national standard diet recommendations, for a diet with no milk and beef and for a vegan diet including an oat-based milk susbstitute.&#13;\n&#13;\nThe major source of GHG in primary food production is the cultivated soil. For the present average food consumption the emissions from the soil comprise 62 %, the share of emissions due to enteric fermentation is 24 %, whereas energy consumption and fertilizer manufacture both contribute about 8 %. Because of the extensive production mode, regarding GHG emissions the environmental performance, of organic production is poor.
Structure-Based Subspace Method for Multichannel Blind System Identification (2017)

In this work, a novel subspace-based method for blind identification of multichannel finite impulse response systems is presented. Here, we exploit directly the block Toeplitz channel's structure in the signal's linear model to build a quadratic cost function, whose minimization leads to the desired channel estimation up to a scalar factor. This method can be extended to estimate any predefined linear structure, e.g., Hankel, that is usually encountered in linear systems. Simulation findings are provided to highlight the appealing advantages of the new structure-based subspace method over the standard subspace method in certain adverse identification scenarios.
Locomotive Emissions Test Stand with Particulate Matter Measurement Integration (2015)

This project builds upon previous research efforts, in which a complete instruction manual and bill of materials was developed for a blueprint that allows any organization in the railroad industry to build their own locomotive emissions measurement setup. A full scale emissions test was conducted to demonstrate the feasibility of a compact and portable setup for locomotive emissions measurement. A mobile laboratory was used for this test and proved to be a quick and convenient method for emissions testing.
Preventing Recurrent Upper Gastrointestinal Bleeding in Patients withHelicobacter pyloriInfection Who Are Taking Low-Dose Aspirin or Naproxen (2001)

Among patients with H. pylori infection and a history of upper gastrointestinal bleeding who are taking low-dose aspirin, the eradication of H. pylori is equivalent to treatment with omeprazole in preventing recurrent bleeding. Omeprazole is superior to the eradication of H. pylori in preventing recurrent bleeding in patients who are taking other NSAIDs.
High Speed Range Enhancement of a Switched Reluctance Motor with Continous Mode (2007)

International audience
How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time (2016)

We provide a tool for data-driven modeling of motility, data being time-lapse recorded trajectories. Several mathematical properties of a model to be found can be gleaned from appropriate model-independent experimental statistics, if one understands how such statistics are distorted by the finite sampling frequency of time-lapse recording, by experimental errors on recorded positions, and by conditional averaging. We give exact analytical expressions for these effects in the simplest possible model for persistent random motion, the Ornstein-Uhlenbeck process. Then we describe those aspects of these effects that are valid for any reasonable model for persistent random motion. Our findings are illustrated with experimental data and Monte Carlo simulations.
Megistoquinones I and II, Two Quinoline Alkaloids with Antibacterial Activity from the Bark of Sarcomelicope megistophylla. (2002)

Two alkaloids, megistoquinone I (1) and megistoquinone II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to quinoline alkaloid series and should be considered as oxidation products of a furo[2,3-b]quinoline precursor. The two alkaloids showed antibacterial properties with minimum inhibitory concentration (MIC) ranging from 2.35 to 5.25 mg/ml for 1 and 0.73 to 1.23 mg/ml for 2.
Sequential Radical Cyclization/Organometallic Addition. On the Mechanism of the Samarium(II) Mediated Barbier Reaction in the Presence of Hexamethylphosphoric Triamide (1990)

Samarium(II) iodide mediated aryl radical cyclization of 1-allyloxy-2-iodobenzene in the presence of hexamethyl-phosphoric triamide (HMPA) produces a solution-stable organo-samarium intermediate that can be trapped with electrophiles (6 examples) or with aldehydes and ketones (Barbier-type coupling, 8 examples). These results suggest that traditional samarium(II) mediated Barbier reactions often proceed by an organometallic addition mechanism.
Steady-State and Transient Characteristics of High-Voltage 4H-SiC Junction Diodes (2005)

Forward current-voltage characteristics, reverse current recovery and post-injection voltage decay are measured for high voltage 4H-SiC p+non+-diodes. The effects of both minority carrier lifetime in diode no-base and injection coefficient of p+-emitter are investigated with respect to device performance at high injection levels.
Retrieval-Based Transformer for Table Augmentation (2023)

Data preparation, also called data wrangling, is considered one of the most expensive and time-consuming steps when performing analytics or building machine learning models.Preparing data typically involves collecting and merging data from complex heterogeneous, and often large-scale data sources, such as data lakes.In this paper, we introduce a novel approach toward automatic data wrangling in an attempt to alleviate the effort of end-users, e.g. data analysts, in structuring dynamic views from data lakes in the form of tabular data.Given a corpus of tables, we propose a retrieval augmented transformer model that is self-trained for the table augmentation tasks of row/column population and data imputation. Our self-learning strategy consists in randomly ablating tables from the corpus and training the retrieval-based model with the objective of reconstructing the partial tables given as input with the original values or headers. We adopt this strategy to first train the dense neural retrieval model encoding portions of tables to vectors, and then the end-to-end model trained to perform table augmentation tasks.We test on EntiTables, the standard benchmark for table augmentation, as well as introduce a new benchmark to advance further research: WebTables.Our model consistently and substantially outperforms both supervised statistical methods and the current state-of-the-art transformer-based models.
Electric-Field Control of Interfering Transport Pathways in a Single-Molecule Anthraquinone Transistor (2015)

It is understood that molecular conjugation plays an important role in charge transport through single-molecule junctions. Here, we investigate electron transport through an anthraquinone based single-molecule three-terminal device. With the use of an electric-field induced by a gate electrode, the molecule is reduced resulting into a 10-fold increase in the off-resonant differential conductance. Theoretical calculations link the change in differential conductance to a reduction-induced change in conjugation, thereby lifting destructive interference of transport pathways.
An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections (2022)

Genomic studies and experiments with permeability-deficient strains have revealed a variety of biological targets that can be engaged to kill Gram-negative bacteria. However, the formidable outer membrane and promiscuous efflux pumps of these pathogens prevent many candidate antibiotics from reaching these targets. One such promising target is the enzyme FabI, which catalyzes the rate-determining step in bacterial fatty acid biosynthesis. Notably, FabI inhibitors have advanced to clinical trials for <i>Staphylococcus aureus</i> infections but not for infections caused by Gram-negative bacteria. Here, we synthesize a suite of FabI inhibitors whose structures fit permeation rules for Gram-negative bacteria and leverage activity against a challenging panel of Gram-negative clinical isolates as a filter for advancement. The compound to emerge, called fabimycin, has impressive activity against >200 clinical isolates of <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Acinetobacter baumannii</i>, and does not kill commensal bacteria. X-ray structures of fabimycin in complex with FabI provide molecular insights into the inhibition. Fabimycin demonstrates activity in multiple mouse models of infection caused by Gram-negative bacteria, including a challenging urinary tract infection model. Fabimycin has translational promise, and its discovery provides additional evidence that antibiotics can be systematically modified to accumulate in Gram-negative bacteria and kill these problematic pathogens.
Intravenous ibandronate injections in postmenopausal women with osteoporosis: One‐year results from the dosing intravenous administration study (2006)

As assessed by BMD, intravenous injections of ibandronate (2 mg every 2 months or 3 mg every 3 months) are at least as effective as the regimen of 2.5 mg orally daily, which has proven antifracture efficacy, and are well tolerated.
Cellulase assay as a method of monitoring grape ripening (2008)

Cellulases are an important family of enzymes found in many plant, bacterial, fungal, and yeast species. Plants encode cellulases [EC ] that catalyze the cleavage of the internal 1,4‐â‐glucosidic linkages of cellulose comprising their own tissue. It has been suggested that plant cellulases are essential for many facets of plant development, including abscission, fruit softening, vascular differentiation and symbiosis. A new fluorescent assay system has been developed to monitor cellulase enzyme activity in a continuous assay format at physiological pH values using the new substrate resorufin beta‐D‐cellobioside. Analysis of cellulase activity from grape samples obtained from the Pinot Noir and Pinot Gris varietals at developmental stages from before veraison through to the final ripe berry indicate the presence of a cellulase inhibitor or inhibitors whose level changes with ripening and correlates to the total mass ratio of dissolved sucrose (BRIX) and titratable acidity (TA) for the various samples. Protein and protease assays of the same samples appear to indicate that the inhibitor compound(s) may not be protein related. The identity of the inhibitor compound(s) is currently under investigation. These methods are being developed as a method to estimate optimum harvest conditions in an automated high‐throughput (HTS) format.
Outdoor Sound Source Detection Using a Quadcopter with Microphone Array (2017)

[abstFig src='/00290001/17.jpg' width='300' text='System architecture for sound source detection using a quadcopter with a microphone array' ] This paper addresses sound source detection in an outdoor environment using a quadcopter with a microphone array. As the previously reported method has a high computational cost, we proposed a sound source detection algorithm called multiple signal classification based on incremental generalized singular value decomposition (iGSVD-MUSIC) that detects the sound source location and temporal activity at low computational cost. In addition, to relax the estimation error problem of a noise correlation matrix that is used in iGSVD-MUSIC, we proposed correlation matrix scaling (CMS) to achieve soft whitening of noise. As CMS requires a parameter to decide the degree of whitening, we analyzed the optimal value of the parameter by using numerical simulation. The prototype system based on the proposed methods was evaluated with two types of microphone arrays in an outdoor environment. The experimental results showed that the proposed iGSVD-MUSIC-CMS significantly improves sound source detection performance, and the prototype system achieves real-time processing. Moreover, we successfully clarified the behavior of the CMS parameter by using a numerical simulation in which the empirically-obtained optimal value corresponded with the analytical result. * * This work is an extension of our publication “Takuma Ohata et al.: Improvement in outdoor sound source detection using a quadrotor-embedded microphone array, IROS 2014, pp.1902-1907, 2014.”
Chemistry in Crop Protection. Part 4. Pyrazole Chemistry in Crop Protection (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nonlinear analysis of cross-coupled oscillator circuits (2008)

We study global stability properties of a class of cross-coupled oscillators which admit the representation of a dynamic system in feedback with a static nonlinearity. We present sufficient conditions for almost global convergence of the solutions to a limit cycle when the feedback gain is in the neighborhood of the bifurcation point. The result is then extended to the synchronization of interconnected identical cross-coupled oscillators.
Abstract 4071: A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer (2019)

Background: Previous studies have reported that tumor debris and inflammation made by high-intensity focused ultrasound (HIFU) therapy induced the antitumor immune response, however, HIFU as a monotherapy is still not potent enough to eradicate tumors and treat distant metastasis. We have reported that mechanical HIFU (M-HIFU), that will mechanically destroy tumor cells/tissues through acoustic cavitation, induced stronger antitumor immune response compared to conventional thermal HIFU (T-HIFU) that will cause thermal ablation of tumors. In the present study, we established an immune based combination therapy of M-HIFU and immune checkpoint blockade to enhance systemic antitumor immune response and treated distant/metastatic tumors in murine breast cancer models.Methods and Results: HER2 oncogene-dependent murine breast cancer cell line, MM3MG-HER2, was established in our lab. In mice with bilateral implantation of MM3MG-HER2 tumors, M-HIFU monotherapy induced stronger HER2-specific cellular response and inhibited the growth of HIFU-untreated distant tumors as well as HIFU treated-tumors, more potently than T-HIFU. Flow cytometry and immunohistochemical analysis of tumor microenvironment revealed significantly stronger accumulation of activated T cell and NK cells in M-HIFU-treated tumors. On the other hand, M-HIFU induced stronger expression of programmed death-ligand 1 (PD-L1) on various immune cells in both sides of tumors than T-HIFU therapy or no treatment control. Based on these findings, we investigated the combination therapy of M-HIFU and PD-1/PD-L1 axis blockades, and found significantly enhanced tumor-specific cellular immune response compared to each monotherapy, which resulted in improved therapeutic effect against distant tumors as well as HIFU treated-tumors. Furthermore, immune cell depletion studies demonstrated that both CD8+ T cells and NK cells played an essential role for the antitumor efficacy in this combinatory therapy against both HIFU-treated tumors and untreated distant tumors.Conclusion: this study provides strong rational evidence that M-HIFU combined with PD-1/PD-L1 axis blockades could be a promising treatment strategy against advanced breast cancer with metastatic lesion.Citation Format: Shinya Abe, Takuya Osada, Kensuke Kaneko, Pei Zhong, Herbert K. Lyerly. A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4071.
Electron-Transfer Oxidation Properties of Unsaturated Fatty Acids and Mechanistic Insight into Lipoxygenases (2006)

Rate constants of photoinduced electron-transfer oxidation of unsaturated fatty acids with a series of singlet excited states of oxidants in acetonitrile at 298 K were examined and the resulting electron-transfer rate constants (k(et)) were evaluated in light of the free energy relationship of electron transfer to determine the one-electron oxidation potentials (E(ox)) of unsaturated fatty acids and the intrinsic barrier of electron transfer. The k(et) values of linoleic acid with a series of oxidants are the same as the corresponding k(et) values of methyl linoleate, linolenic acid, and arachidonic acid, leading to the same E(ox) value of linoleic acid, methyl linoleate, linolenic acid, and arachidonic acid (1.76 V vs SCE), which is significantly lower than that of oleic acid (2.03 V vs SCE) as indicated by the smaller k(et) values of oleic acid than those of other unsaturated fatty acids. The radical cation of linoleic acid produced in photoinduced electron transfer from linoleic acid to the singlet excited state of 10-methylacridinium ion as well as that of 9,10-dicyanoanthracene was detected by laser flash photolysis experiments. The apparent rate constant of deprotonation of the radical cation of linoleic acid was determined as 8.1 x 10(3) s(-1). In the presence of oxygen, the addition of oxygen to the deprotonated radical produces the peroxyl radical, which has successfully been detected by ESR. No thermal electron transfer or proton-coupled electron transfer has occurred from linoleic acid to a strong one-electron oxidant, Ru(bpy)3(3+) (bpy = 2,2'-bipyridine) or Fe(bpy)3(3+). The present results on the electron-transfer and proton-transfer properties of unsaturated fatty acids provide valuable mechanistic insight into lipoxygenases to clarify the proton-coupled electron-transfer process in the catalytic function.