gebhart/patrepeval huggingface dataset:
The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice (2019)

ANP32B belongs to a family of evolutionary conserved acidic nuclear phosphoproteins (ANP32A-H). Family members have been described as multifunctional regulatory proteins and proto-oncogenic factors affecting embryonic development, cell proliferation, apoptosis, and gene expression at various levels. Involvement of ANP32B in multiple processes of cellular life is reflected by the previous finding that systemic gene knockout (KO) of Anp32b leads to embryonic lethality in mice. Here, we demonstrate that a conditional KO of Anp32b is well tolerated in adult animals. However, after immune activation splenocytes isolated from Anp32b KO mice showed a strong commitment towards Th17 immune responses. Therefore, we further analyzed the respective animals in vivo using an experimental autoimmune encephalomyelitis (EAE) model. Interestingly, an exacerbated clinical score was observed in the Anp32b KO mice. This was accompanied by the finding that animal-derived T lymphocytes were in a more activated state, and RNA sequencing analyses revealed hyperactivation of several T lymphocyte-associated immune modulatory pathways, attended by significant upregulation of Tfh cell numbers that altogether might explain the observed strong autoreactive processes. Therefore, Anp32b appears to fulfill a role in regulating adequate adaptive immune responses and, hence, may be involved in dysregulation of pathways leading to autoimmune disorders and/or immune deficiencies.
IL2 Laparoscopic Renal Surgery : Past, Present, and Future(IL) (2006)

affairs will become commonplace throughout the world alld that at major laparoscopic centers, fewer than 5% of 'procedures will require open surgery.
Evolution of Nanocrystallinity in Periodic Mesoporous Anatase Thin Films (2004)

Herein we report the first kinetic study of the intrachannel wall phase-transition of amorphous titania to nanocrystalline anatase for periodic mesoporous titania thin films, monitored by time-resolved in situ high-temperature X-ray diffraction. Structural transformations associated with the phase transition are further probed by high-resolution scanning electron microscopy and transmission electron microscopy. The model found to be most consistent with the kinetic data involves 1D diffusion-controlled growth of nanocrystalline anatase within the spatial confines of the channel walls of the mesostructure. The observation of anisotropic, rod-shaped anatase nanocrystals preferentially aligned along the channel axis implies that the framework of the liquid-crystal-templated mesostructure guides the crystal growth.
A leucine‐to‐phenylalanine substitution in the acetylcholine receptor ion channel in a family with the slow‐channel syndrome (1995)

The slow-channel syndrome is one of several congenital myasthenic syndromes that result from inherited abnormalities of the ion channel of the skeletal muscle acetylcholine receptor (AChR). The ion channel is formed by the second transmembrane domains (M2) of the four AChR subunits. We screened the genomic DNA of one family with the slow-channel syndrome for mutations in the coding sequences for the M2 domains of the four AChR subunits and report the identification of a missense mutation that causes a leucine-to-phenylalanine substitution at position 269 of the epsilon subunit in three affected members of a family with the slow-channel syndrome. We propose that this mutation may be responsible for the disease.
Evaluation of mechanical properties of extruded and radial expanded Lactoprene� 8812 polymer stents (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Chemical and toxicological studies of coal gasification wastewater circulated through a cooling tower (1984)

Argonne National Laboratory is studying health and environmental issues related to coal gasification, using data and samples from the oxygen-blown slagging fixed-bed gasifier at the University of North Dakota Energy Research Center (UNDERC). The pilot study reported here developed preliminary chemical and toxicological data needed to evaluate the health and environmental, as well as the process, implications of using partially treated gasifier wastewater in cooling towers. This minimal-treatment process removes organic compounds by solvent extraction and removes ammonia and acid gas by steam stripping; then, without intermediate biological treatment, the wastewater is reused in a cooling tower. Samples were collected of both the influent wastewater to the cooling tower and the effluent in the tower's blowdown pipeline. These samples were analyzed for the presence of organic chemicals and trace metals and tested for mutagenic and teratologic activity. Results indicate that the UNDERC solvent-extracted and steam-stripped coal gasification wastewaters doe not contain any easily observed mutagenic or cytotoxic activity. The blowdown water sampled was not cytotoxic or mutagenic after phenol removal and ten-fold concentration. Initial indications are that UNDEREC cooling tower blowdown water may contain teratogenically active compounds. Phenolic material is volatilized in the cooling tower and 85 to 90% ismore » lost as a vapor effluent. Probably less than 10% oxidative degradation of phenols occurs in the UNDERC cooling tower. Hydantoins and most inorganic elements are concentrated in the blowdown water approximately ten-fold, as expected. Trace element distributions of zinc and lead in the blowdown water are not as predicted and are unexplained. The aerodynamic size of the drift aerosol may be 12 ..mu..m or greater, depending on the characteristics of the cooling tower's eliminators. 26 references, 2 figures, 13 tables.« less
Athermal silica-based optical add/drop multiplexerconsisting of arrayedwaveguide gratings and double gate thermo-optical switches (2000)

A 16 channel optical add/drop multiplexer with temperature independent operation has been fabricated using planar lightwave circuit technology. The device consists of two athermal arrayed waveguide gratings and double-gate thermo-optic switches. The crosstalk from its main input port to main output port is better than –35 dB with a fibre-to-fibre insertion loss of better than 12 dB over a temperature range of 10–80°C.
Half Wavelength Open Loop Bandpass Filters with Transmission Zeros (2007)

This paper presents a novel source/load multi-resonator coupling method with greater design flexibility for microstrip single mode coupled resonator filters. Source/load coupling with multiple resonators is useful for obtaining additional transmission zeros and high rejection at finite frequencies in the stopband. A narrow arm which is connected to the source or load and designed for obtaining the coupling with a nearby resonator is extended to the non-adjacent resonator of the source or load to obtain bypass coupling. Filters with transmission zeros both in upper and lower stopbands are synthesized and designed using microstrip half wavelength folded resonators.
Enabling Wearable and Other Novel Applications through Flexible TFTs (2016)

Mechanical flexibility is a key feature for the next generation of display‐based electronic products. An essential component of this capability is flexible TFT technology, which requires a materials set specifically designed to perform optimally under mechanical stress. Progress to this end has been made by several companies, including Polyera Corp.
Table S3 from Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer (2023)

&lt;p&gt;Interferon pathway mutation and copy number alterations&lt;/p&gt;
Experiment-selector cross-validated targeted maximum likelihood estimator for hybrid RCT-external data studies (2022)

Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined with external data) with the optimal bias-variance tradeoff, we develop a novel experiment-selector cross-validated targeted maximum likelihood estimator for randomized-external data studies (ES-CVTMLE). This estimator utilizes two estimates of bias to determine whether to integrate external data based on 1) a function of the difference in conditional mean outcome under control between the RCT and combined experiments and 2) an estimate of the average treatment effect on a negative control outcome (NCO). We define the asymptotic distribution of the ES-CVTMLE under varying magnitudes of bias and construct confidence intervals by Monte Carlo simulation. We evaluate ES-CVTMLE compared to three other data fusion estimators in simulations and demonstrate the ability of ES-CVTMLE to distinguish biased from unbiased external controls in a real data analysis of the effect of liraglutide on glycemic control from the LEADER trial. The ES-CVTMLE has the potential to improve power while providing relatively robust inference for future hybrid RCT-external data studies.
West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. (2003)

The 2002 WNV infection outbreak in Ontario caused serious morbidity and mortality in the subset of patients who had encephalitis or neuromuscular weakness severe enough to require hospital admission.
Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs (2019)

Garcinol, a dietary factor obtained from <i>Garcinia indica</i>, modulates several key cellular signaling pathways as well as the expression of miRNAs. Acquired resistance to standard therapies, such as erlotinib and cisplatin, is a hallmark of non-small cell lung cancer (NSCLC) cells that often involves miRNA-regulated epithelial-to-mesenchymal transition (EMT). We used A549 cells that were exposed to transforming growth factor beta 1 (TGF-β1), resulting in A549M cells with mesenchymal and drug resistant phenotype, and report that garcinol sensitized resistant cells with mesenchymal phenotype to erlotinib as well as cisplatin with significant decrease in their IC<sub>50</sub> values. It also potentiated the apoptosis-inducing activity of erlotinib in A549M and the endogenously mesenchymal H1299 NSCLC cells. Further, garcinol significantly upregulated several key EMT-regulating miRNAs, such as miR-200b, miR-205, miR-218, and let-7c. Antagonizing miRNAs, through anti-miRNA transfections, attenuated the EMT-modulating activity of garcinol, as determined by mRNA expression of EMT markers, E-cadherin, vimentin, and Zinc Finger E-Box Binding Homeobox 1 (ZEB1). This further led to repression of erlotinib as well as cisplatin sensitization, thus establishing the mechanistic role of miRNAs, particularly miR-200c and let-7c, in garcinol-mediated reversal of EMT and the resulting sensitization of NSCLC cells to standard therapies.
ChemInform Abstract: Stereoselective Aldol Coupling of Cobalt‐Complexed Alkynyl Aldehydes. (1990)

Abstract Reaction of the trimethylsilyl enol ethers (I) and (IV) with the formyl alkynyldicobalt hexacarbonyl complexes (II), prepared from the corresponding alkynals and dicobalt octacarbonyl, yields the aldol adducts (III) and (V).
Prothrombin time assay for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicentre field trial (2012)

− The intra-laboratory CV was 4.5-19.3% (for 19 ng/ml), 1.2-8.3% (160 ng/ml), and 0.9-5.0% (643 ng/ml) ◆ The CV of the calibrators was 4.4-6.5% for the central PT reagent compared with 12.5-27.2% for local PT reagents (Table 2)
Intra–Lymph Node Prime-Boost Vaccination against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial (2011)

MKC1106-MT showed immunogenicity and evidence of disease control in a defined patient population. These findings support further development of this investigational agent and the concept of therapeutic vaccination in metastatic melanoma.
Multistage WDM passive access networks: design and cost issues (2003)

The advantages of employing passive optical architectures in the access network have been largely recognized. Particularly, developments in optical technologies have made the realization of wavelength division multiplexing passive optical networks (WDM-PONs) feasible and cost-effective. These networks are more future-proof than conventional PONs, thanks to their intrinsic optical transparency and their extremely high transmission capacity. A very useful optical routing device, called a waveguide grating router, is the basic building-block of new PON architectures capable of connecting a large number of users or to improve the use of the optical bandwidth. In this paper the feasibility of these architectures is discussed by considering the costs and the technological limitations on the optical components.
Compact T-shaped ring bandpass filter with source-load coupled structure for WPT (2016)

A T-shaped ring band pass filter using source-load coupled technique is proposed in this paper. T-shaped ring structure effectively utilizes the area and makes it easier to tune filter's center operating frequency, which is also helpful in expanding the bandwidth. Source-load coupled technique is used in the proposed design to increase the transmission zeros on the operating frequency in both sides so that the out-of-band rejection can be further improved. First, validation in simulation is carried out to prove the use of source-load coupling. Then a demonstrating filter has been designed, optimized, fabricated and measured. The filter has low insertion loss of 0.35dB, return loss of −18dB when operating in 2.47GHz, and measurement shows good agreement with simulation. Such filter can be in good use in microwave power transmission in microwave-RFID application.
Network Systems Biology for Drug Discovery (2010)

Systems biology provides a platform for integrating multiple components and interactions underlying cell, organ, and organism processes in health and disease. Beyond traditional approaches focused on individual molecules or pathways, bioinformatic network analysis of high-throughput data sets offers an opportunity for integration of biological complexity and multilevel connectivity. Emerging applications in rational drug discovery range from targeting and modeling disease-corrupted networks to screening chemical or ligand libraries to identification/validation of drug-target interactions for improved efficacy and safety.
Noninvasive mapping of water diffusional exchange in the human brain using filter‐exchange imaging (2012)

We present the first in vivo application of the filter-exchange imaging protocol for diffusion MRI. The protocol allows noninvasive mapping of the rate of water exchange between microenvironments with different self-diffusivities, such as the intracellular and extracellular spaces in tissue. Since diffusional water exchange across the cell membrane is a fundamental process in human physiology and pathophysiology, clinically feasible and noninvasive imaging of the water exchange rate would offer new means to diagnose disease and monitor treatment response in conditions such as cancer and edema. The in vivo use of filter-exchange imaging was demonstrated by studying the brain of five healthy volunteers and one intracranial tumor (meningioma). Apparent exchange rates in white matter range from 0.8±0.08 s(-1) in the internal capsule, to 1.6±0.11 s(-1) for frontal white matter, indicating that low values are associated with high myelination. Solid tumor displayed values of up to 2.9±0.8 s(-1). In white matter, the apparent exchange rate values suggest intra-axonal exchange times in the order of seconds, confirming the slow exchange assumption in the analysis of diffusion MRI data. We propose that filter-exchange imaging could be used clinically to map the water exchange rate in pathologies. Filter-exchange imaging may also be valuable for evaluating novel therapies targeting the function of aquaporins.
ChemInform Abstract: SPECTROSCOPIC CHARACTERIZATION OF AN ELECTROPHILIC TRANSITION‐METAL‐METHYLENE COMPLEX, η5‐C5H5((C6H5)2PCH2CH2P(C6H5)2)FE:CH2+ (1980)

Abstract Durch Behandeln des Komplexes (I) in CDZCI, bei tiefen Temp. mit 2‐20 Äquivalenten Trifluoressigsäure wird der kationische Titel‐Carben‐Komplex (II) erzeugt.
Linearly representable entropy vectors and their relation to network coding solutions (2009)

In this work, we address the following question: ¿When can we guarantee the optimality of linear coding at all internal nodes of a network?¿ While sufficient conditions for linear coding throughout the network are known, it is not clear whether relaxing the linearity constraints at the terminal nodes can result in simpler operations at the internal nodes. We present a novel method to analyze the space of network solutions using the constraints resulting from the network topology, and we identify sufficient conditions for an optimal linear solution at all internal nodes. These conditions are also sufficient to characterize the rate region only in terms of Shannon information inequalities.
Prostaglandin E1-containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication (2013)

The findings of this study suggest that Nano-PGE1 improves the walking activity of femoral artery-ligated rats through the accumulation and sustained release of PGE1 .
Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells (2023)

Supplementary Figure 5 from BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells
Abstract 865: Small molecule-mediated modulation of Ras elicits inhibition of phospho ERK signaling through negative feedback on SOS1 (2018)

Abstract Oncogenic mutation of Ras is responsible for more than 30% of all human tumors. Therefore, pharmacological modulation of Ras has attracted great interest as a therapeutic strategy. Our laboratory has recently discovered small molecules that activate Son of Sevenless (SOS)-catalyzed nucleotide exchange on Ras and paradoxically inhibit downstream signaling. Here we describe how pharmacologically targeting SOS1 induces biphasic modulation of Ras-GTP and downstream ERK levels. We consistently observed this phenotype in a variety of cell lines expressing different Ras mutant isoforms, and using multiple chemotypes of compound. In elucidating the molecular mechanism, we observed that compound treatment caused an increase in phosphorylation at ERK consensus motifs on SOS1 that was not observed with the expression of a non-phosphorylatable S1178A SOS1 mutant, or after pre-treatment with an ERK inhibitor. Phosphorylation at S1178 on SOS1 is known to inhibit the association between SOS1 and GRB2 and disrupt SOS1 membrane localization. Consistent with this, we show that wild-type SOS1 and GRB2 dissociated in a time dependent fashion in response to compound treatment, and conversely, this interaction was enhanced with the expression of a S1178A SOS1 mutant. Pre-treatment with an ERK inhibitor prevented compound-induced inhibition of the association between SOS1 and GRB2. Furthermore, in cells expressing either S1178A SOS1 or a constitutively membrane-bound CAAX box tagged SOS1 mutant, we observed elevated Ras-GTP levels over time in response to compound, as compared to the biphasic changes in Ras-GTP exhibited in cells expressing wild-type SOS1. These results show that small molecule agonists of SOS1 cause paradoxical inhibition of Ras-GTP and MAPK signaling in Ras mutant cancer cells, through negative feedback on SOS1. Overall, these compounds provide us with the unique opportunity to better understand the biological functions of SOS and Ras in cancer cells, and may aid in the discovery of small molecules to treat Ras-driven tumors. Citation Format: Jennifer E. Howes, Denis T. Akan, Michael C. Burns, Qi Sun, Andrew J. Little, DeMarco V. Camper, Jason R. Abbott, Jason Phan, Taekyu Lee, Olivia W. Rossanese, Alex G. Waterson, Stephen W. Fesik. Small molecule-mediated modulation of Ras elicits inhibition of phospho ERK signaling through negative feedback on SOS1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 865.
Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neurodegenerative Disorders (2009)

The term neurodegenerative disorders, encompasses a variety of underlying conditions, sporadic and/or familial and are characterized by the persistent loss of neuronal subtypes. These disorders can disrupt molecular pathways, synapses, neuronal subpopulations and local circuits in specific brain regions, as well as higher-order neural networks. Abnormal network activities may result in a vicious cycle, further impairing the integrity and functions of neurons and synapses, for example, through aberrant excitation or inhibition. The most common neurodegenerative disorders are Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis and Huntington's disease. The molecular features of these disorders have been extensively researched and various unique neurotherapeutic interventions have been developed. However, there is an enormous coercion to integrate the existing knowledge in order to intensify the reliability with which neurodegenerative disorders can be diagnosed and treated. The objective of this review article is therefore to assimilate these disorders' in terms of their neuropathology, neurogenetics, etiology, trends in pharmacological treatment, clinical management, and the use of innovative neurotherapeutic interventions.
The automatic translation of discourse structures (2000)

We empirically show that there are significant differences between the discourse structure of Japanese texts and the discourse structure of their corresponding English translations. To improve translation quality, we propose a computational model for rewriting discourse structures. When we train our model on a parallel corpus of manually built Japanese and English discourse structure trees, we learn to rewrite Japanese trees as trees that are closer to the natural English rendering than the original ones. 1 Motivation Almost all current MT systems process text one sentence at a time. Because of this limited focus, MT systems cannot re-group and re-order the clauses and sentences of an input text to achieve the most natural rendering in a target language. Yet, even between languages as close as English and French, there is a 10% mismatch in number of sentences --- what is said in two sentences in one language is said in only one, or in three, in the other (Gale and Church, 1993). For ...