gebhart/patrepeval huggingface dataset:
Osmotic regulation of neuronal nitric oxide synthase expression in the rat amygdala: Functional role for nitric oxide in adaptive responses? (2006)

Water-deprivation-induced osmotic stress leads to activation of a number of adaptive responses. Nitric oxide (NO) has been implicated in the modulation of these responses, as the amygdala has been implicated in ingestive behavior and modulation of autonomic homeostatic functions. Here we investigated the effects of water deprivation on neuronal nitric oxide synthase (nNOS) expression within the rat amygdala; a brain area involved in modulating ingestive behavior and autonomic function. Water deprivation resulted in significant increases in nNOS immunoreactivity (-ir) within different regions of the amygdala compared with euhydrated rats. Maximal increases were observed in the anteroventral (118 +/- 9 vs. 47 +/- 3 neurons), anteriodorsal (133 +/- 9 vs. 77 +/- 3), and posterioventral (175 +/- 5 vs. 71 +/- 5) parts of the medial amygdala. The basomedial nucleus (65 +/- 4 vs. 39 +/- 3) and posterior basolateral nucleus (19 +/- 2 vs. 5 +/- 1) of the amygdala and the capsular (21 +/- 2 vs. 6 +/- 1) and medial (44 +/- 6 vs. 22 +/- 3) parts of the central nucleus of the amygdala also showed increased nNOS-ir in dehydrated rats. Water deprivation had no effect on nNOS-ir in areas such as the cortical, anterior basolateral, and intercalated nuclei of the amygdala. Microinjection of an NO donor, DEA-NONOate, into the central amygdala resulted in a pressor and tachycardic response that was attenuated by a soluble guanylate cyclase inhibitor. These observations suggest that activation of the nitrergic system is prevalent throughout the amygdala following water deprivation and suggest that the up-reguation of nNOS could play a significant role in the integrative response to osmotic stress.
Solubility studies of inorganic–organic hybrid nanoparticle photoresists with different surface functional groups (2015)

The solubility behavior of Hf and Zr based hybrid nanoparticles with different surface ligands in different concentrations of photoacid generator as potential EUV photoresists was investigated in detail. The nanoparticles regardless of core or ligand chemistry have a hydrodynamic diameter of 2-3 nm and a very narrow size distribution in organic solvents. The Hansen solubility parameters for nanoparticles functionalized with IBA and 2MBA have the highest contribution from the dispersion interaction than those with tDMA and MAA, which show more polar character. The nanoparticles functionalized with unsaturated surface ligands showed more apparent solubility changes after exposure to DUV than those with saturated ones. The solubility differences after exposure are more pronounced for films containing a higher amount of photoacid generator. The work reported here provides material selection criteria and processing strategies for the design of high performance EUV photoresists.
Performance analysis and improvements on a hybrid cascade architecture for multi-layer neural networks (2003)

A series of improvements in a hybrid architecture for multilayer networks is presented. This architecture incorporates the incoming connection strengths and the neurons of each layer into one stage by a multiplexing scheme, hence reducing the complexity of interstage wiring. An analysis of the performance of this architecture is performed and, based on its results, the authors propose a number of improvements. Also, a three-layer network has been implemented in a double metal, single polysilicon p-well CMOS technology based on the proposed improvements. The performance of the improved version is analyzed and compared to the original structure. Bounds on the operating speed of the system are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Better mousetraps (1994)

As a technologist, working in the field of storage systems, and employed by a company that develops and sells a wide range of computer systems and components, I've learned that the biggest impediments to technology transfer---including better OS support for specific applications---are not technical, but economic. This paper summarizes some of these issues, and considers how best we might respond to them.
Li+ conducting garnet-type oxide sintering triggered by an H+/Li+ ion-exchange reaction (2020)

We demonstrate the fabrication of a solid state Li/Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub>/Li(Ni<sub>1/3</sub>Co<sub>1/3</sub>Mn<sub>1/3</sub>)O<sub>2</sub> battery at a remarkably low temperature (400 °C) using low temperature sintering triggered by an ion-exchange reaction.
A Dynamic Model of Colonic Concentrations of Delayed-Release 5-Aminosalicylic Acid (Asacol) (2008)

Purpose: 5-aminosalicylic acid (5-ASA) is used for induction and maintenance therapy in patients with ulcerative colitis. Asacol is 5-ASA coated in Eudragit-S, a pH sensitive capsule, Designed for release in the terminal ileum and colon. Asacol is administered in three daily doses as the standard dosing regimen. Administration of Asacol as a single daily may improve patient adherence. Pharmacokinetic data for orally administered 5-ASA is generally limited to urine, fecal and blood concentrations of the drug. These are not as well correlated to clinical efficacy as actual levels of the drug in the colon. This study is a computer simulation of the pharmacokinetic distributions of 5-ASA in the colon under one-a-day and three-a-day dosing regimens of Asacol. We predict that one-a-day dosing will not substantially alter 5-ASA concentrations or time course in the colon. Methods: Using published data on gastrointestinal motility, 5-ASA absorption and clearance of colonic contents with defecation, the levels of 5-ASA in the four major segments of the colon were predicted after Asacol administration by a dynamic model using STELLA software. 5-ASA levels were predicted in the healthy colon as well as during variations in motility and the frequency of defecation, designed to simulate active ulcerative colitis. Results: Model predictions indicated no substantial differences in total or regional 5-ASA levels under the various simulated conditions between 800 mg doses of Asacol administered t.i.d compared with one 2400 mg dose administered q.a.m. Steady state concentrations were achieved in 96 hours for both dosing regimens. In the healthy colon, each dosing regimen produced a maximum colonic retention of ∼5.1 g and average of ∼4.1 g, with 39% in the ascending colon, 33% in the transverse colon, and 14% each in the descending and sigmoid colon. Simulated increases in colon motility or the defecation rate exaggerated this uneven distribution, increasing the portion of drug found in the proximal colon. Reductions in normal motility conserved drug levels throughout the colon, whereas increasing the defecation rate up to 12 daily produced dramatic declines in all regions, with a maximum total colonic retention of ∼2.3 g and an average colonic retention of ∼1.2 g. Conclusion: These data suggest that Asacol may be administered as a single dose with little change in efficacy. Results also support experimental and clinical observations that increased 5-ASA dose or alternative route of administration may be necessary to achieve adequate 5-ASA concentrations in the distal colon during acute exacerbations of ulcerative colitis.
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma (2019)

In Table The correct responses as well as the definition for SCR are below.
MATERIALS CHARACTERIZATIONS FOR DEVELOPMENT OF AN OVERLAY DESIGN PROCEDURE. FINAL REPORT (1989)

In 1984 a 400B Road-Rater was purchased by the Maine Department of Transportation. One of the primary intentions for the use of this piece of equipment was to assist in the aid of designing structural overlays. As a result a project was established for the purpose of calibrating or correlating deflection data to the structural strength of roadways. The model used in this study is based upon the Chevron Elastic Theory and is heavily influenced by the Kentucky model. The local information was obtained from carefully selected projects representing 5 different specific types of subgrade. When the deflections were taken, temperature and time were also recorded. Immediately after this test was performed pavement samples were cut and saved for further testing. Field CBR values were then taken on top of the gravel and again on top of the subgrade. Water contents and granular samples of the material were also taken. After the basic model was established, it was refined so that features such as temperature could be added to correct the pavement modulus. Eventually the model was expanded to the extent that the AASHTO Structural Design Equation was included. To verify the model, several recently constructed projects were tested and the deflections data backcalculated to determine the effective pavement thickness.
Usability of Security Specification Approaches for UML Design: A Survey. (2009)

Since it is the de facto language for software specification and design, UML is the target language used by almost all state of the art contributions handling security at specification and design level. However, these contributions differ in the covered security requirements, specification approaches, verification tools, etc. This paper investigates the main approaches adopted for specifying and enforcing security at UML design and surveys the related state of the art. The main contribution of this paper is a discussion of these approaches from usability viewpoint. A set of criteria has been defined and used in this usability discussion. The discussed UML approaches are stereotypes and tagged values, OCL, and behavior diagrams. Extending the UML meta-language or creating new meta-languages for security specification are also covered by this study.
CIDE Proteins in Human Health and Disease (2019)

Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family-CIDEA, CIDEB, and CIDEC (also known as fat-specific protein 27 (FSP27)). CIDEA and FSP27 are primarily expressed in adipose tissue, while CIDEB is expressed in the liver. Originally, based upon their homology with DNA fragmentation factors, these proteins were identified as apoptotic proteins. However, recent studies have changed the perception of these proteins, redefining them as regulators of lipid droplet dynamics and fat metabolism, which contribute to a healthy metabolic phenotype in humans. Despite various studies in humans and gene-targeting studies in mice, the physiological roles of CIDE proteins remains elusive. This review will summarize the known physiological role and metabolic pathways regulated by the CIDE proteins in human health and disease.
PCR-based random amplified polymorphic DNA fingerprinting of Yersinia pseudotuberculosis and its practical applications (1994)

The random amplified polymorphic DNA (RAPD) fingerprinting method was used to distinguish between various strains of Yersinia pseudotuberculosis, a causative agent of gastroenteritis in humans. The RAPD test uses arbitrarily chosen DNA oligomers of 10 nucleotides to prime DNA synthesis from genomic sites to which they are accidentally matched or almost matched. Most 10-nucleotide primers yielded strain-specific arrays. Ten Y. pseudotuberculosis type strains were distinguishable from each other by analyzing the RAPD arrays produced by using primers with a 50% G+C content. The RAPD patterns of Y. pseudotuberculosis strains were found to be constant regardless of the presence or absence of the large plasmid. RAPD tests were subsequently used to identify 30 clinical isolates of Y. pseudotuberculosis that were collected as the causative agent of an outbreak of Izumi fever, a disease showing clinical symptoms characteristic of atypical scarlet fever, in Japan. The RAPD arrays from all of the isolates yielded common patterns that were unique to each primer used. Since those 30 isolates belonged to serotype 5a and the restriction digest patterns of their large plasmids were all the same, the results of the RAPD tests confirmed the view that those isolates were from a single source and indicated that the RAPD test can be practically applied to survey transmission of the bacterium in humans.
Correction to Accurate Visualization of Operating Commercial Batteries Using Specialized Magnetic Resonance Imaging with Magnetic Field Sensing (2021)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Accurate Visualization of Operating Commercial Batteries Using Specialized Magnetic Resonance Imaging with Magnetic Field SensingKonstantin Romanenko*Konstantin RomanenkoMore by Konstantin Romanenkohttps://orcid.org/0000-0002-8178-3590, Philip W. KuchelPhilip W. KuchelMore by Philip W. Kuchel, and Alexej JerschowAlexej JerschowMore by Alexej Jerschowhttps://orcid.org/0000-0003-1521-9219Cite this: Chem. Mater. 2021, 33, 17, 7132Publication Date (Web):August 20, 2021Publication History Published online20 August 2021Published inissue 14 September 2021https://pubs.acs.org/doi/10.1021/acs.chemmater.1c02724https://doi.org/10.1021/acs.chemmater.1c02724correctionACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views802Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (461 KB) Get e-Alertsclose Get e-Alerts
Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionIdentification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase InhibitorToru Asano*, Hitoshi Yamazaki, Chiyoshi Kasahara, Hirokazu Kubota, Toru Kontani, Yu Harayama, Kazuki Ohno, Hidekazu Mizuhara, Masaharu Yokomoto, Keiji Misumi, Tomohiko Kinoshita, Mitsuaki Ohta, and Makoto TakeuchiCite this: J. Med. Chem. 2014, 57, 16, 7143Publication Date (Web):August 19, 2014Publication History Published online19 August 2014Published inissue 28 August 2014https://pubs.acs.org/doi/10.1021/jm501222phttps://doi.org/10.1021/jm501222pcorrectionACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views778Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (119 KB) Get e-Alertsclose Get e-Alerts
Investigation of High Energy Density Anode Materials Based on Sio-Sncoc in Full Cell Configuration (2014)

State-of-the-art lithium ion battery technology is being developed for large scale applications such as electric vehicles (EVs) and hybrid electric vehicles (HEVs). For this purpose, lithium ion batteries must have long term cycling performance with high capacity. The graphite which is currently used as an anode material has a capacity of about 372 mAhg -1 where lithium forms graphite intercalation compounds LiC 6 with excellent reversibility. Ongoing research efforts have focused on utilizing various materials (oxides, alloys, tin, silicon) to increase battery capacity, cycle life, and charge-discharge rates. Attention has been recently given to the potential of metal oxide anodes for lithium-ion batteries because of their low price and their high theoretical capacities (more than 600 mAhg -1 ). However, these anode materials suffer from their poor cycleability due to the volume expansion of the lithiated material. New materials based on the mixture of M a O b oxides (M: Si, Sn, Mo, Ge) and Sn x Co y C z alloys were prepared and tested as anodes for lithium batteries. In the M a O b - Sn x Co y C z composite, Sn x Co y C z will play the role of buffer for M a O b anode and improve its cyleability and M a O b will provide more capacity. In full cell configuration, this study will focus on the cheapest SiO- Sn x Co y C z system. We used ultra-high energy ball milling (UHEM) methods to prepare SiO-Sn 30 Co 30 C 40 anode materials. This anode material is tested in full cell configuration using the 5V LiNi 0.5 Mn 1.5 O 4 spinel, NMC and ANL-NMC materials. The results of these investigations will be presented. The submitted abstract has been created by UChicago Argonne, LLC, Operator of Argonne National Laboratory (“Argonne”). Argonne, a U.S. Department of Energy Office of Science laboratory, is operated under Contract No. DE-AC02-06CH11357.
Radiative muon absorption in calcium (1985)

The photon spectrum from radiative absorption of negative muons in $^{40}\mathrm{Ca}$ has been measured with a high-resolution pair spectrometer. The data are analyzed in order to determine the induced pseudoscalar coupling constant ${g}_{p}$ in nuclear matter. When compared to models which use a realistic nuclear response function and avoid the closure approximation, a value of ${g}_{p}$/${g}_{A}$=4.0\ifmmode\pm\else\textpm\fi{}1.5 is obtained, which indicates a quenching of this coupling compared to the nucleonic value by a factor 0.57\ifmmode\pm\else\textpm\fi{}0.25.
Laser remote chemical sensors at Raytheon (2002)

Raytheon and the U.S. Army have been developing laser remote chemical sensors for the last decade. This has included advanced transmitter and sensor development, field testing, and concepts for spacecraft, aircraft, unmanned aerial vehicles, ground-mobile transports, and fixed sites. The WILDCAT sensor utilizes a wavelength agile CO<SUB>2</SUB> laser with output energy of 1 J/pulse at a repetition rate of 100 Hz for ranges of 40 km. The receiver is composed of a 60 cm dia. telescope and HgCdTe detector, integrated into a gimbal system with full hemispherical scan. Algorithms allow for real-time data processing and concentration map display. An all solid state sensor breadboard has also been developed that is capable of 300 (mu) J output at 8-12 micrometers and 300 Hz repetition rate. The system is based on a Nd:YAG pump slab laser and two-stage, angle-tuned, optical parametric oscillator wavelength shifter. The system provides for power efficiency, compactness, and light weight that are consistent with manportability. Anticipated horizontal range is 3 km on the ground and 5 km vertically. Analysis of a space-based, low earth orbit system shows that chemical and biological species detection can be performed effectively by sensors derived from the laser components developed under these programs.
Effect of Supplemental Translaminar Facet Screw Fixation on the Stability of Stand-Alone Anterior Lumbar Interbody Fusion Cages Under Physiologic Compressive Preloads (2004)

In vivo during activities of daily living, interbody cage constructs are subject to varying compressive preloads due to external loads generated by paraspinal musculature, and our results suggest that the stability created by the cage (reduction in segmental angular motion) is not constant. The cage construct is likely to be least stable in extension during activities that impart low compressive preloads to the lumbar spine. Supplemental translaminar facet screw fixation will enhance stability of the motion segment treated with threaded cages, particularly during conditions of low compressive preloads, the very condition in which the cage alone is least effective in providing stability.