gebhart/patrepeval huggingface dataset:
Formulation of percolating thermal underfills using hierarchical self-assembly of micro- and nanoparticles by centrifugal forces and capillary bridging (2012)

Thermal underfills are crucial to support integration density scaling of future integrated circuit packages. Therefore, a sequential process using hierarchical self-assembly of micro- and nanoparticles is proposed to achieve percolating thermal underfills with enhanced particle contacts. The three main process steps hereby are assembly of filler particles by centrifugation, formation of nanoparticle necks by capillary bridging, and the backfilling of the porous structure with an unfilled capillary adhesive. Numerical simulations predicting trajectories and distributions of micron-sized particles dispensed into a rotating disk are presented. The trajectories exhibit a strong dependence on the particle size; thus in the case of polydisperse filler particles nonuniform particle beds may result. An efficient centrifugal disk design with spiral-like guiding structures is experimentally validated. Defect-free, percolating particle beds in confined space with fill fractions of 46 vol-% to 66 vol-%, i.e., close to the theoretical limit, are also presented. The self-assembly of nanoparticles, forming enhanced thermal contacts between the percolating filler particles, is discussed. Two consecutive evaporation patterns during the capillary bridging process were identified: 1) dendritic network growth and 2) collapse of capillary bridges. The concave neck topology could only be achieved at temperatures below the boiling point. An optimal evaporation temperature of 60°C with respect to in-plane uniformity and neck shape was identified. Existing thermal gradients normal to the cavity surface resulted in strongly asymmetric neck formation in the cavity. Hence, uniform heating in an oven is the preferred method to initiate evaporation. Two types of bimodal dielectric necks are demonstrated. Polystyrene acts as the adhesive between thermally conductive alumina particles to form mechanically stable dielectric necks after an annealing step at 140°C. Interstitial and core-shell necks are presented. Finally, a benchmark study was performed to compare the effective thermal conductivity of the percolating thermal underfill with and without necks with state-of-the-art capillary underfills. A close to fivefold improvement could be obtained for diamond filler particles with silver necks (3.8 W/m-K).
Fast turn-off of high voltage 4H–SiC npn BJTs from the saturation on-state regime (2010)

Fast turn-off of high-voltage (breakdown voltage ⩾ 3 kV) 4H–SiC npn bipolar junction transistors driven in a deeply saturated regime has been reported. In the conventional turn-off mode (base current break), the turn-off delay and current fall times are 80 ns and 100 ns, respectively. It is shown that these times can be made as short as 20 and 4 ns, respectively, if a reverse base current pulse of appropriate amplitude is applied to sweep out minority carriers from the base. The experimental values of delay and turn-off times well coincide with those calculated in terms of the charge control model.
Ytterbium-doped all glass leakage channel fibers with highly fluorine-doped silica pump cladding (2009)

All glass leakage channel fibers have been demonstrated to be a potential practical solution for power scaling in fiber lasers beyond the nonlinear limits in conventional large mode area fibers. The all glass nature with absence of any air holes is especially useful for allowing the fibers to be used and fabricated much like conventional fibers. Previously, double clad active all glass leakage channel fibers used low index polymer as a pump guide with the drawbacks of being less reliable at high pump powers and not being able to change fiber outer diameter independent of pump guide dimension. In this work, we demonstrate, for the first time, ytterbium-doped double clad all glass leakage channel fibers with highly fluorine-doped silica as pump cladding. The new all glass leakage channel fibers have no polymer in the pump path and have independent control of fiber outer diameters and pump cladding dimension, and, therefore, enable designs with smaller pump guide for high pump absorption and, at the same time, with large fiber diameters to minimize micro and macro bending effects, a much desired features for large core fibers where intermodal coupling can be an issue due to a much increased mode density. An ytterbium-doped double clad PM fiber with core diameter of 80 microm is also reported, which can be coiled in 76 cm diameter coils.
The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand (2013)

It's the water that matters. Pairs of benzo- and perfluorobenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy-driven binding, and indistinguishable binding affinities (see picture). These data support the pervasive theory that the lock-and-key model disregards an important component of binding: the water, which fills the binding pocket of the protein and surrounds the ligand.
Morphologic, Stereologic, and Morphometric Evaluation of the Nervous System in Young Cynomolgus Monkeys (Macaca fascicularis) Following Maternal Administration of Tanezumab, a Monoclonal Antibody to Nerve Growth Factor (2014)

Tanezumab, an antibody to nerve growth factor, was administered to pregnant cynomolgus monkeys at 0, 0.5, 4, and 30 mg/kg weekly, beginning gestation day (GD) 20 through parturition (∼GD165). Maternal tanezumab administration appeared to increase stillbirths and infant mortality, but no consistent pattern of gross and/or microscopic change was detected to explain the mortality. Offspring exposed in utero were evaluated at 12 months of age using light microscopy (all tissues), stereology (basal forebrain cholinergic and dorsal root ganglia neurons), and morphometry (sural nerve). Light microscopy revealed decreased number of neurons in sympathetic ganglia (superior mesenteric, cervicothoracic, and ganglia in the thoracic sympathetic trunk). Stereologic assessment indicated an overall decrease in dorsal root ganglion (thoracic) volume and number of neurons in animals exposed to tanezumab 4 mg/kg (n = 9) and 30 mg/kg (n = 1). At all tanezumab doses, the sural nerve was small due to decreases in myelinated and unmyelinated axons. Existing axons/myelin sheaths appeared normal when viewed with light and transmission electron microscopy. There was no indication of tanezumab-related, active neuron/nerve fiber degeneration/necrosis in any tissue, indicating decreased sensory/sympathetic neurons and axonal changes were due to hypoplasia or atrophy. These changes in the sensory and sympathetic portions of the peripheral nervous system suggest some degree of developmental neurotoxicity, although what effect, if any, the changes had on normal function and survival was not apparent. Overall, these changes were consistent with published data from rodent studies.
The Digital Communications Point of View (2014)

When detailing how to dimension a transceiver, it can seem natural to first clarify what is expected from such a system. This chapter focuses on the consequences for transceiver architectures of the signal processing associated with the digital communications. The concept of the complex envelope is of particular importance as the lowpass signal embeds all the statistical characteristics of interest of the modulated bandpass RF signal it represents. The chapter points out that such complex envelopes have additional practical advantages over the use of real bandpass signal representations when performing analytical derivations. It also discusses the bandpass concept for noise signals as classically encountered in practical transceivers. Finally, the chapter reviews some digital modulation schemes that are representative of the different statistics that can be encountered in classical wireless standards.
Designing the model patient: Data-driven virtual patients in medical education (2016)

In this paper we describe ModelPatient, a software application developed to allow health sciences educators to create and deliver educational cases that are based on and simulate real patient behavior. ModelPatient uses data from Electronic Medical Record Systems (EMRS) or from publically available medical data sets in combination with Bayesian network (BN) models to generate virtual patient (VP) cases. Because the underlying models are based on real data, each decision made by a learner affects outcome probabilities. Therefore the behavior of a VP reflects how a real patient with the same medical condition would have reacted to the learners' actions. We believe that data- and model-driven approaches to creating VPs would allow educators to create higher-fidelity teaching cases and offer richer educational experience to learners.
LATMAPA: Load-Adaptive Throughput- MAximizing Preamble Allocation for Prioritization in 5G Random Access (2017)

Persistently high traffic loads and heterogeneous quality of service (QoS) requirements arising from machine-to-machine communication in wireless 5G systems require effective random access prioritization. 5G systems will likely evolve from mature wireless technologies, e.g., long term evolution (LTE). LTE conducts random access through preamble contention based on slotted Aloha principles. Prior studies have mainly examined random access prioritization for addressing temporary traffic bursts through manipulating the access contention procedure on a given set of preambles, such as adapting the number of permitted transmission attempts and back off windows. We conduct a detailed study of random access prioritization through separating (splitting) the random access preambles into non-overlapping priority classes. Based on the obtained insights, we develop the Load-Adaptive Throughput-MAximizing Preamble Allocation (LATMAPA). LATMAPA automatically adjusts the preamble allocation to the priority classes according to the random access load and a priority tuning parameter. Extensive analytical and simulation evaluations indicate that LATMAPA provides effective QoS differentiation across a wide range of random access loads, which are expected in 5G systems.
Advances in Test Methods for Designing Optimised Ceramic Blends from a Raw Material Supply Perspective (2011)

Traditionally, clay blend development for ceramic applications has been done empirically from background knowledge of how the individual components are likely to behave in a given ceramic system. At Sibelco, modern advances in testing methodologies allows the rapid design and development of new clay blends tailored to customer needs. Three topics of key importance in the development of optimised ceramic clay blends are presented and discussed; namely, particle size, rheology and mineralogy. The paper concludes with two examples of how these methods can be brought together to develop high performance clay blends that meet the customers’ needs.
Monaural Speech Enhancement for a Hose-Shaped Rescue Robot with Air-Jet Noise (2019)

This paper presents a monaural speech enhancement method for a hose-shaped rescue robot based on a deep speech prior. Speech enhancement is crucial to make a robot operator succeed in detecting human voices because audio signals captured by a microphone on the robot are contaminated by ego-noise. We have been developed three enhancement methods: 1) a blind speech enhancement called robust nonnegative matrix factorization (RNMF), 2) an extension of RNMF with a pre-trained noise model, and 3) another extension of RNMF with a deep speech prior, i.e., a pre-trained speech model based on deep learning. In this paper, we develop a new extension of RNMF by combining the pre-trained noise and speech models as a unified model and evaluated these methods on a hose-shaped rescue robot whose ego-noise consists of vibration-motor and air-jet noise. Experimental results show that the new method outperforms the three RNMF methods when the signal-to-noise ratio is equal to or less than +5 dB.
At-Sea Evaluation of an Underwater Vehicle Behavior for Passive Target Tracking (2018)

In this paper, we describe an unmanned underwater vehicle (UUV) behavior designed to track nearby vessels using bearing-only measurements obtained from a rigidly mounted planar hydrophone array-one that was originally designed for active sonar use but is repurposed for passive sonar use. Upon detecting a target, a maneuver is executed to resolve the port/starboard bearing ambiguity. The maneuver is heuristically designed with the aim of reducing the effects of end-fire, self-noise during maneuvers, and other noise/spurious measurements on the bearing ambiguity decision. After resolving the bearing ambiguity, the vehicle continuously adjusts its heading to track the target by keeping it broadside to the array. The performance of this behavior, as well as that of the passive sonar itself, is evaluated through field trials in the approaches to Boston Harbor using a Bluefin-21 UUV. In total, 19 successful behavior tests are described where the UUV resolves the bearing ambiguity and tracks either a static source emitting a predefined waveform or the platform noise of a medium-sized catamaran underway.
strain cannot encode a (1991)

We have determined the nucleotide sequence of Q8/9 d gene of the BALB/c strain of mice, isolated from Steinmetz's cosmid library. As for all other class I genes of the Qa region, the Q8/9 d gene spans approx- imately 4.7 kilobases (kb) and consists of seven exons and six introns. A seven bases deletion in exon 3 results in the occurrence of an early termination codon. Thus the Q8/9 d gene cannot encode a normal class I protein. Comparison of the nucleotide sequence of the Q8/9 d gene with that of other class I MHC genes revealed a stronger homology to Q7 and Q8 than to K, D, L, TL, and other Q genes. However, the gene cannot originate from a mere fusion between Q8 and Q9 genes except if the ancestor to putative Q8 d was markedly different from the present Q8 b gene. Using polymerase chain reaction (PCR) technology, we have confirmed the presence of a Q8/9 gene, identical to that present in cosmid 46.1, in the genome of BALB/cJ (Qa-2I°w). Finally, it has been reported that cDNA clone 94-A, which codes for a Qa-2 antigen, could derive from a transcript of gene Q8/9 ~. The nucleotide sequences of gene Q8/9 d and of cDNA clone 94-A are distinctly different in their 5' regions, in spite of an almost perfect matching in their 3' regions. Thus, clone 94-A cannot derive from an mRNA transcrib- ed from the Q8/9 a gene.
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A 2 Proves Renal Origins of Urinary PGI-M and TX-M (2018)

These data show that PGI-M and TX-M can be derived exclusively from the kidney without contribution from prostacyclin made by endothelial cells or thromboxane A<sub>2</sub> by platelets in the general circulation. Previous work relying on urinary metabolites of prostacyclin and thromboxane A<sub>2</sub> as markers of whole-body endothelial and platelet function now requires reevaluation.
Glucan Is a Component of theMycobacterium tuberculosisSurface That Is Expressed In Vitro and In Vivo (2002)

The outermost layer of Mycobacterium tuberculosis is composed primarily of two polysaccharides, glucan (GC) and arabinomannan. To analyze the surface polysaccharide composition of M. tuberculosis, we generated a monoclonal antibody (MAb) that binds M. tuberculosis GC and is known as MAb 24c5. Immunofluorescence and whole-mount immunoelectron microscopy indicated that GC is on the outermost portion of the bacteria. M. tuberculosis strains Erdman and CDC 1551 were analyzed for their ability to bind MAb 24c5 after in vitro growth in media with and without the detergent Tween 80. MAb 24c5 bound to Erdman and CDC 1551 at all culture times with only slightly greater apparent affinity after extended culture in the absence of Tween 80, indicating that a stable amount of GC polysaccharide antigen is associated with the cell surface of M. tuberculosis. An enzyme-linked immunosorbent assay indicated that GC is antigenically similar to glycogen, and the amount of GC antigen increased in the media of M. tuberculosis cultures grown either with or without the detergent Tween 80. Other nontuberculosis mycobacteria have antigenically similar GCs on their surfaces after in vitro growth. Inoculation of mice with live bacilli but not inoculation with dead bacilli elicited a strong antibody response to GC consistent with production of this antigen in vivo. Our results provide a more comprehensive picture of the M. tuberculosis cell envelope and the conditions that allow expression of M. tuberculosis GC.
Silica-Based Packaging Structure for D-band RF module (2018)

This paper presents a packaging structure in D-band, which is a stacked structure of a silica-based substrate, a print wiring board, and a metal chassis. Key structures, which are transition structures in RF transmission paths and band-pass filters, are designed. The fabricated transitions show good frequency responses due to silica with excellent electrical characteristics. The fabricated three-resonator filters show small deviations in frequency responses among samples along with good filter performances.
ChemInform Abstract: SYNTH. SUBSTITUIERTER 7H‐1‐PYRINDINESSIGSAEUREESTER (1970)

Abstract Das Pyrindin‐Derivat (I) wurde zu (II) methyliert, zu (III) hydrolysiert und durch vorsichtige Behandlung mit Phosphoroxychlorid in das Pyrindin‐Derivat (IV) umgewandelt, das dann mit Zinkstaub und Bromessigsäuremethylester zu (VI) umgesetzt wurde.
Cross-Genre Feature Comparisons for Spoken Sentence Segmentation (2007)

Automatic sentence segmentation of spoken language is an important precursor to downstream natural language processing. Previous studies combine lexical and prosodic features, but can impose significant computational challenges because of the large size of feature sets. Little is understood about which features most benefit performance, particularly for speech data from different speaking styles. We compare sentence segmentation for speech from broadcast news versus natural multi-party meetings, using identical lexical and prosodic feature sets across genres. Results based on boosting and forward selection for this task show that (1) features sets can be reduced with little or no loss in performance, and (2) the contribution of different feature types differs significantly by genre. We conclude that more efficient approaches to sentence segmentation and similar tasks can be achieved, especially if genre differences are taken into account.
Advanced Environmental Barrier Coatings Development for Si-Based Ceramics (2005)

Advanced environmental barrier coating concepts based on multi-component HfO2 (ZrO2) and modified mullite systems are developed for monolithic Si3N4 and SiC/SiC ceramic matrix composite (CMC) applications. Comprehensive testing approaches were established using the water vapor cyclic furnace, high pressure burner rig and laser heat flux steam rig to evaluate the coating water vapor stability, cyclic durability, radiation and erosion resistance under simulated engine environments. Test results demonstrated the feasibility and durability of the environmental barrier coating systems for 2700 to 3000 F monolithic Si3N4 and SiC/SiC CMC component applications. The high-temperature-capable environmental barrier coating systems are being further developed and optimized in collaboration with engine companies for advanced turbine engine applications.
Plasmonic MIM and MSM Waveguide Couplers for Plasmonic Integrated Computing System (2022)

Plasmonic metal-insulator-metal waveguide (MIM WG) is a promising building block of devices of a plasmonic computing system, and metal-semiconductor-metal (MSM) WG offers high-speed detection of plasmon signals. MIM and MSM WG couplers are an essential component of any integrated computing system that requires an interface between the plasmonic devices and the electronic circuits. However, the MIM and MSM WG couplers have not yet been explored and systematically studied. This work analyzes and benchmarks various coupling schemes of the plasmonic MIM and MSM WGs to single out the best coupling approach. From the detailed numerical analysis and considering the trade-offs among coupling loss, total capacitance, system noise, and bandwidth, a holistic metric is introduced to quantify and compare the system-level performance of the couplers, and a novel coupling scheme is identified as the most attractive choice for coupling the two WGs.
Effect of a Stable Prostacyclin Analogue on Canine Renal Allograft Rejection (1987)

The effect of OP-41483 (Ono Pharmaceutical Co., Osaka, Japan), a stable prostacyclin analogue, on canine renal allograft rejection was investigated. Administration for 4 days after transplantation significantly increased renal cortical blood flow and urine output when compared with untreated dogs with renal allografts. Serum creatinine levels remained relatively low during postoperative days 1-4. Mean animal survival time was prolonged. Vascular lesions and mononuclear cell infiltration were greatly diminished in biopsy specimens removed on day 4. This stable prostacyclin analogue provided a degree of protection against canine renal allograft rejection.
Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin (2010)

Its substantial antiviral activity and low toxicity in vitro suggest that GRFN-1 and/or its derivatives may have therapeutic potential as topical and/or systemic agents directed against HIV-1.
Using multiple saliencies for the estimation of flux, position, and velocity in AC machines (1998)

This paper presents an improved method of estimating flux angle, rotor position, and velocity by tracking the position of spatial saliencies in an AC machine. Specifically, a machine model is presented which accurately models the behavior of AC machines with multiple spatial harmonic saliencies. The effects of multiple spatial harmonic saliencies on the estimation of flux angle, position, and velocity is analyzed, and methods are presented utilizing multiple spatial harmonic saliencies to provide wide bandwidth, high accuracy estimates of flux angle, rotor position, and velocity.
.pi.-Facial selection in intermolecular Diels-Alder reactions: total syntheses of (+)-actinobolin and (+)-5,6,10-triepiactinobolin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.pi.-Facial selection in intermolecular Diels-Alder reactions: total syntheses of (+)-actinobolin and (+)-5,6,10-triepiactinobolinAlan P. Kozikowski, Thaddeus R. Nieduzak, Toshiro Konoike, and James P. SpringerCite this: J. Am. Chem. Soc. 1987, 109, 17, 5167–5175Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ja00251a021https://doi.org/10.1021/ja00251a021research-articleACS PublicationsRequest reuse permissionsArticle Views797Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts