gebhart/patrepeval huggingface dataset:
Potential role of circulating tumor DNA (ctDNA) in the early diagnosis and post-operative management of localised pancreatic cancer. (2017)

4101 Background: Pancreatic cancer remains a devastating disease, with the diagnosis typically being made late. ctDNA has shown promise as a screening test for various tumor types. The detection of ctDNA post curative intent surgery has been associated with a high risk of recurrence in multiple solid tumors. We explored the potential of ctDNA to improve pancreatic cancer outcomes. Methods: Data from separate US and Australian series were combined. Plasma samples were collected prior to surgery in both studies and post-operative samples were collected in Australia from cases undergoing curative intent surgery. Clinicians were blinded to ctDNA results and adjuvant therapy was at clinician discretion. Tissue samples from both series were analyzed at Johns Hopkins University. Next generation sequencing was used to search for somatic KRAS mutations in the primary tumors and in cell-free DNA in the plasma. Clinico-pathologic, treatment and outcome data were collected. Results: 119 pts had a ctDNA sample at diagnosis (median age 67 years, 56.3% male). Sixty six pts (55.5 %) had detectable ctDNA, including 3/7 (42.9%) with stage I disease, 54/99 (54.5%) with stage II disease, 4/8 (50%) with stage III disease and 5/5 (100%) with metastases. Specific codon 12 KRAS (G12D, G12V or G12R) mutations were identified in the tumor tissue of 12/16 (75%) patients who had a ctDNA sample collected post-surgery. At a median follow-up of 15.2 months, 7/12 (58.3%) pts had recurred, including 3/8 (37.5%) with no detectable ctDNA and 4/4 (100%) with detectable ctDNA post-surgery (HR 4.9, p = 0.04). Detectable ctDNA post-surgery was significantly associated with poor overall survival (HR 6.93, p = 0.006), with a median of 8 months for pts with detectable ctDNA. Conclusions: ctDNA shows promise as a pancreatic cancer screening test, being detectable in a high proportion of pts with early stage disease. The detection of ctDNA post operatively predicts a very high risk of recurrence. The clinical utility of ctDNA to guide adjuvant therapy decision making, and its potential as a real-time marker of treatment effect, are being explored in further studies. Clinical trial information: ACTRN12612000763842.
Supplementary Data from Epidermal Growth Factor Receptor–Mediated Membrane Type 1 Matrix Metalloproteinase Endocytosis Regulates the Transition between Invasive versus Expansive Growth of Ovarian Carcinoma Cells in Three-Dimensional Collagen (2023)

Supplementary Data from Epidermal Growth Factor Receptor–Mediated Membrane Type 1 Matrix Metalloproteinase Endocytosis Regulates the Transition between Invasive versus Expansive Growth of Ovarian Carcinoma Cells in Three-Dimensional Collagen
Transmission Characteristics in Liquid-Crystal-Infiltrated Photonic Crystal Fibers (2008)

Optical spectra were measured by varying the temperature of liquid-crystal-infiltrated photonic crystal fibers. We obtained a transmission of several wavelengths attributable to the photonic bandgap effect in conventional wavelength bands (1530–1560 nm). The transmission peak at a specific wavelength enabled the achievement of more than 20 dB by varying the temperature of the liquid-crystal-infiltrated photonic crystal fiber at 1550 nm band.
Evaluation of new ozone generator designed for oxide film formation by molecular beam epitaxy method (1991)

The quality of ozone vapor produced with a new ozone generator was evaluated. The ozone vapor was produced by evaporation of liquid ozone after accumulating it in a ozone vessel at various temperatures between 75 and 95 K. Mass analysis of the ozone vapor revealed that the purity of ozone in the vapor depended on both the ozone vessel temperature during liquefaction and that during evaporation. The purity was ∼70% when liquid ozone accumulation temperatures higher than 90 K were used. The activity of the ozone vapor was investigated by oxidation of a Cu foil under low pressure condition. The formation of a CuO layer by exposure to the ozone vapor (pressure: ∼5×10−4 Pa) at 300 °C was confirmed through x-ray photoelectron spectroscopy analysis.
Harmonics Reduction Control of Source Current of Electrolytic Capacitorless Inverter for Position-sensorless Drive System of Induction Motors (2020)

This paper proposes a novel system for harmonics reduction control of the source current of electrolytic capacitorless inverters for a position-sensorless drive system of an induction motor (IM). The proposed system is based on the estimation of the primary flux linkage. In this study, the application range of the control system of the IM is extended to a three-phase-to-three-phase electrolytic capacitorless inverter. Moreover, a direct dc-link current control is employed to improve the source current waveform. The validity of the control system is confirmed through experimental results.
A Comparative Study of the Effect of Carbamazepine and Valproic Acid on the Pharmacokinetics and Metabolic Profile of Topiramate at Steady State in Patients with Epilepsy (2005)

Renal excretion remains a major route of TPM elimination, even in the presence of enzyme induction. The twofold increase in TPM-CL/F in patients taking CBZ can be ascribed, at least in part, to stimulation of the oxidative pathways leading to formation of 2,3-diol-TPM and 10-OH-TPM. VPA was not found to have any clinically significant influence on TPM pharmacokinetic and metabolic profiles.
Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors (2021)

Abstract Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma is likely to reflect the antigenic composition of local viral strains, we hypothesized that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to a national registry of hospitalized COVID-19 patients supported this hypothesis. These findings have implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge.
Photoluminescence and scintillation properties of Pr-doped (Lu, Y)2Si2O7 crystals (2023)

Abstract Pr-doped (Lu 1− x , Y x ) 2 Si 2 O 7 ( x = 0.25, 0.5, and 0.75) crystals were synthesized by the floating zone method. Emission peaks due to 5d–4f transitions of Pr 3+ were observed at 300 nm under excitation of both UV light and X-rays. Scintillation decay times of 19–22 ns were obtained, and they originated from the 5d–4f transitions of Pr 3+ . Afterglow levels became high from 64.7 to 541 ppm as the Y-admixed concentration increased. The light yields were estimated to be 560–700 photons MeV −1 by comparing the channels of photoabsorption peaks from the pulse height spectra of 137 Cs γ -rays measured using prepared crystals and commercial Gd 2 SiO 5 reference.
A Psychoacoustic Model With Partial Spectral Flatness Measure For Tonality Estimation (2014)

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 2014
Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily (2010)

Dasatinib is considered an effective drug in imatinib-resistant chronic myeloid leukemia. Although reported to be well-tolerated, severe events such as pleural or pericardial effusion have been reported at 140 mg daily. We examined our chronic myeloid leukemia patients treated with dasatinib at 100 mg or 50 mg daily and identified 4 of 13 patients who developed marked effusion formation. In 2 patients, grade III/IV pleural and/or pericardial effusions were recorded. All 4 patients had received previous anti-leukemia therapy but none had pre-existing cardiac or pulmonary diseases. In 3 patients, dasatinib had to be discontinued despite treatment with diuretics and glucocorticosteroids. In conclusion, dasatinib-treated chronic myeloid leukemia patients are at risk for the development of pleural and pericardial effusions even when the drug is administered at 100 mg or 50 mg daily. Therefore, all patients should be examined for pre-existing comorbidity and risk factors before starting dasatinib and all should have repeated chest X-rays during long-term dasatinib therapy.
General impedance synthesizer using minimal configuration of switching converters (2006)

A general impedance synthesizer using a minimum number of switching converters is studied in this paper. We begin with showing that any impedance can be synthesized by a circuit consisting of only two simple power converters, one storage element (e.g., capacitor), and one dissipative element (e.g., resistor) or power source. The implementation of such a circuit for synthesizing any desired impedance can be performed by: (i) programming the input current given the input voltage such that the desired impedance function is achieved; and (ii) controlling the amount of power dissipation (generation) in the dissipative element (source) so as to match the required active power of the impedance to be synthesized. Then, the instantaneous power will automatically be balanced by the storage element. Such impedance synthesizers find a lot of applications in power electronics. For instance, a resistance synthesizer can be used for power factor correction (PFC), a programmable capacitor or inductor synthesizer (comprising of small high-frequency converters) can be used for control applications.
Triplet ground states of trimethylenemethanes (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriplet ground states of trimethylenemethanesMatthew S. Platz, J. M. McBride, R. Daniel Little, James J. Harrison, Andrew Shaw, Stephen E. Potter, and Jerome A. BersonCite this: J. Am. Chem. Soc. 1976, 98, 18, 5725–5726Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/ja00434a067https://doi.org/10.1021/ja00434a067research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimization of T-DNA architecture for Cas9-mediated mutagenesis in Arabidopsis (2018)

ABSTRACT Bacterial CRISPR systems have been widely adopted to create operator-specified site-specific nucleases. Such nuclease action commonly results in loss-of-function alleles, facilitating functional analysis of genes and gene families We conducted a systematic comparison of components and T-DNA architectures for CRISPR-mediated gene editing in Arabidopsis, testing multiple promoters, terminators, sgRNA backbones and Cas9 alleles. We identified a T-DNA architecture that usually results in stable ( i.e. homozygous) mutations in the first generation after transformation. Notably, the transcription of sgRNA and Cas9 in head-to-head divergent orientation usually resulted in highly active lines. Our Arabidopsis data may prove useful for optimization of CRISPR methods in other plants.
<p>Efficacy of a new local limb salvage treatment for limb-threatening diabetic foot wounds - a randomized controlled study</p> (2019)

We can conclude that PEDYPHAR could be an effective and safe conservative local adjuvant treatment for cases of diabetic foot infection.<b>Registration number in ClinicalTrials.gov:</b> NCT01531517.
Application of a Distributed Element Roughness Model to Additively Manufactured Internal Cooling Channels (2023)

Abstract Design for cooling effectiveness in turbine blades relies on accurate models for dynamic losses and heat transfer of internal cooling passages. Metal additive manufacturing (AM) has expanded the design space for these configurations, but can give rise to large-scale roughness features. The range of roughness length scales in these systems makes morphology resolved computational fluid dynamics (CFD) impractical. However, volumetric roughness models can be leveraged, as they have computational costs orders of magnitude lower. In this work, a discrete element roughness model (DERM), based on the double-averaged Navier–Stokes equations, is presented and applied to additively manufactured rough channels, representative of gas turbine blade cooling passages. Unique to this formulation of DERM is a generalized sheltering-based treatment of drag, a two-layer model for spatially averaged Reynolds stresses, and explicit treatment of dispersion. Six different AM rough surface channel configurations are studied, with roughness trough to peak sizes ranging from 15% to 60% nominal channel passage half-width, and the roughness Reynolds number ranges from Rek = 60 to 300. DERM predictions for spatially and temporally averaged mean flow quantities are compared to previously reported direct numerical simulation results. Good agreement in the mean velocity profiles, stress balances, and drag partitions are observed. While DERM models are typically calibrated to specific deterministic roughness morphologies at comparatively small roughness Reynolds numbers, the present more generalized DERM formulation has wider applicability. Here, it is demonstrated that the model can accommodate random roughness of large scale, typical of AM.
Interactive Effects of Year and Academic Predictors on College GPA. (1971)

DOCUMENT RESUME TM 000 484 Bowers, John; Loeb, Jane Interactive Ettects of Year and Academic Predictors on College GPA. Feb 71 13p.; Paper presented at the Annual Meeting of the American Educational Research Association, New York, New York, February 1971 EDRS Price MF-$0.65 HC-$3.29 Academic Performance, Academic Standards, Aptitude Tests, *College Admission, *Grade Point Average, Higher Education, Predictive Measurement, *Predictor Variables, *Selection, Statistical Analysis, *Test Reliability ACT C, *American College Test Composite, University of Illinois Multiple regression equations predicting first semester grade point average (GPA) from high school percentile rank (HSPR) and Composite score on the American College Test (ACT:C) were examined for five successive fall freshman classes 0965-1969) at the University of Illinois. Slopes were significantly different among the five equations. Further analysis indicated a systematic decline in the ACT:C regression coefficients over time while the HSPA coefficients remained approximately constant. Possible explanations advanced for these findings were unequal test score intervals, a low GPA ceiling, and changes in the GPA criterion. (Author) U.S. DEPARTMENT OF HEALTH, EDUCATION & WELFARE OFFICE OF EDUCATION THIS DOCUMENT HAS BEEN REPRODUCED EXACTLY AS RECEIVED FROM THE PERSON OR ,,, ORGANIZATION ORIGINATING IT POINTS OF VIEW Ok OPINIONS STATED DO NOT NECESSARILY REPRESENT OFFICIAL OFFICE OF EDUOhi CATION POSITION OR POLICY INTERACTIVE EFFECTS OF YEAR AND ACADEMIC PREDICTORS ON COLLEGE GPA John Bowers Office of Instructional Resources Jane Loeb University Office of School and College Relations University of Illinois Urbana, Illinois A paper presented at the 1971 annual meeting of the American Educational Research Association held in New York, New York.
REAL-TIME BLOCK FLOW TRACKING OF ATRIAL SEPTAL DEFECT MOTION IN 4D CARDIAC ULTRASOUND (2007)

Real-time cardiac ultrasound allows monitoring the heart motion during intracardiac beating heart procedures. Our application assists atrial septal defect (ASD) closure techniques using real-time 3D ultrasound guidance. One major image processing challenge is the processing of information at high frame rate. We present an optimized block flow technique, which combines the probability-based velocity computation for an entire block with template matching. We propose adapted similarity constraints both from frame to frame, to conserve energy, and globally, to minimize errors. We show tracking results on eight in-vivo 4D datasets acquired from porcine beating-heart procedures. Computing velocity at the block level with an optimized scheme, our technique tracks ASD motion at 41 frames/s. We analyze the errors of motion estimation and retrieve the cardiac cycle in ungated images
“Modulazione con farmaci anti-apoptosi mitocondriale di eventi degenerativi e proliferativi in retina” (2005)

La deprivazione da siero rappresenta un modello sperimentale di induzione dell'apoptosi ampiamente utilizzato in diversi sistemi cellulari. In questo contesto sperimentale, la rimozione del siero e qundi di fattori trofici essenziali per la sopravvivenza cellulare è responsabile dell'innesco del programma apoptopico. Questa deprovazione di fattori trofici, che sono in grado di stimolare la sopravvivenza e il differenziamento cellulare, induce apoptosi in molte linee cellulari in vitro.
Rapid Pathogen Identification With Direct Application of MALDI-TOF Mass Spectrometry on an Endophthalmitis Vitreous Sample Without Prior Culture (2019)

Purpose: We report a case of a 72-year-old man with bleb-related endophthalmitis (BRE) whose vitreous samples were directly analyzed with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to rapidly identify the causative organism, whereas the results from conventional microbiological techniques were negative. Methods: We analyzed BRE vitreous samples with MALDI-TOF MS (Vitek MS, bioMérieux) for rapid pathogen identification without prior culture. Samples were also analyzed with standard microbiological methods. Results: Within 1 hour of sample acquisition, MALDI-TOF MS identified Gemella sanguinis from the undiluted vitreous sample from vitrectomy without prior culture with a confidence value of 99.7%. Gram stain and cultures from aqueous and vitreous samples were negative for 28 days after acquisition. The patient’s right-eye vision improved from hand motion to 20/50 2 months later. Conclusions: Our findings suggest that the direct analysis of intraocular samples with MALDI-TOF MS could be a novel, promising adjuvant method of rapid endophthalmitis diagnosis.
Stabilised (H2)Al–E(H)R species, E = P or As, R− = C(SiMe3)2(6-Me-2-pyridyl)− (2000)

Reaction of RECl2 (R− = C(SiMe3)2(6-Me-2-pyridyl)−, E = P or As) with LiAlH4 in THF affords directly bonded aluminium hydride–pnictide hydride complexes as weakly associated hydride bridged dimers, [RE(H)–Al(H)2]2; a strong solvent dependency of these reactions, which had previously been observed with the formation of the disecondary diphosphane in Et2O (E = P), is further confirmed by the formation of RAsH2 from RAsCl2 and LiAlH4 in Et2O.
Aggressive Mechanical Clot Disruption and Low-dose Intra-arterial Third-generation Thrombolytic Agent for Ischemic Stroke: A Prospective Study (2002)

A high rate of recanalization and clinical improvement can be observed in patients with ischemic stroke using low-dose thrombolytic agents with adjunctive mechanical disruption of clot. Moreover, this strategy may reduce the risk of intracerebral hemorrhage observed with thrombolytics.
The Importance of Pairwise Interactions Between Peptide Residues in the Delineation of TCR Specificity (1998)

A minimal, nonamer epitope (TEMEKEGKI) from the reverse transcriptase protein of HIV-1, restricted by H-2Kk, was identified and the function of individual residues determined. Besides classical anchor residues at positions 2 and 9, methionine at position 3 was identified as an important MHC anchor and improved binding of a different (malarial) nonamer epitope to H-2Kk, albeit while also abolishing CTL recognition. Lysine at position 5 was replaceable by alanine for CTL raised against wild-type peptide but abolished recognition for CTL raised against the variant 5ALA peptide, indicating a unidirectional cross-reactivity. Interestingly, one CTL line raised against the 5ALA substituted peptide was permissive for a double substitution at positions 5 and 6, in which lysine was permissive at position 5 only if the adjacent glutamic acid was replaced by alanine. Extensive analysis revealed three distinct patterns of responses with peptides doubly substituted in this region: recognition of both single substitutions but not the double substitution, recognition of only one single substitution but also the double substitution, or recognition of both single substitutions and the double substitution. A second complementary substitution can therefore restore function lost through a first substitution. Thus, no residue acts independently of its neighbors, and pairs of substitutions may give results not predictable from the effects of each taken singly. This finding may have bearing on viral infections (such as HIV), in which the accumulation of two mutations in the epitope may lead to the reengagement of memory CTL previously silenced by the initial mutation.
Optimization of extraordinary optical absorption in plasmonic and dielectric structures (2013)

Extraordinary optical absorption (EOA) can be obtained by plasmonic surface structuring. However, studies that compare the performance of these plasmonic devices with similar structured dielectric devices are rarely found in the literature. In this work we show different methods to enhance the EOA by optimizing the geometry of the surface structuring for both plasmonic and dielectric devices, and the optimized performances are compared. Two different problem types with periodic structures are considered. The first case shows that strips of silicon on a surface can increase the absorption in an underlying silicon layer for certain optical wavelengths compared to metal strips. It is then demonstrated that by topology optimization it is possible to generate nonintuitive surface designs that perform even better than the simple strip designs for both silicon and metals. These results indicate that in general it is important to compare the absorption performance of plasmonic devices with similarly structured dielectric devices in order to find the best possible solution.
Signal‐to‐noise ratio and MR tissue parameters in human brain imaging at 3, 7, and 9.4 tesla using current receive coil arrays (2015)

In standard experimental conditions, SNR increased supralinearly with field strength (SNR ∼ B0 (1.65) ). To take full advantage of this gain, the deteriorating B1 -homogeneity and the decreasing T2 (*) have to be overcome.