gebhart/patrepeval huggingface dataset:
Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease (2005)

High-dose chemotherapy followed by autologous stem cell transplantation can improve the outcome of relapsed and refractory Hodgkin's disease (HD) patients. The objective of the trial was to determine the mobilizing potential of the DHAP salvage regimen (dexamethasone, cytarabine, cisplatin) for the collection of peripheral blood stem cells (PBSC) in patients with relapsed HD. The target yield of harvesting CD34 + cells was > or =2 x 10(6)/kg in order to support the subsequent myeloablative chemotherapy. Most of the 105 patients included were intensively pre-treated with different combination chemotherapy regimens prior to mobilization. The use of DHAP followed by granulocyte colony-stimulating factor (G-CSF; 10 microg/kg) resulted in the successful collection of adequate numbers of PBSC in 97.1% of patients (102 of 105) with a median harvest of CD34+ cells of 13 x 10(6)/kg (range 2.6 - 85.1). More than 2.0 x 10(6) CD34+ cells/kg were achieved in 65 of 103 (63%) patients after 1 apheresis, the maximum number of aphereses for all patients was 3. It was found that the optimal time of PBSC harvest was at days 13 - 16 after initiating the mobilization regimen. These results demonstrate that the salvage chemotherapy regimen, such as DHAP combined with G-CSF, can be successfully used to mobilize PBSC in HD patients.
(K0.44,Na0.52,Li0.04) (Nb0.84,Ta0.10,Sb0.06)O3Ferroelectric Ceramics (2009)

Recent progress in (K0.44, Na0.52, Li0.04)O3-based ceramics (KNN) with special emphasis on(K0.44,Na0.52,Li0.04)(Nb0.84,Ta0.10,Sb0.06)O3 (KNN-LT-LS) is reviewed concisely. The base KNN and its compositional derivatives are analyzed in terms of dopant-property relationships, which are then extended to the ternary derivatives. The effects of processing conditions such as humidity, precursor purity, and oxygen partial pressure during sintering are elaborated on from a phenomenological perspective. It is also shown that the spontaneous polarization is sensitive to the processing route chosen for synthesis (mixed oxide versus perovskite routes). Special attention is devoted to the discussion of the morphotropic phase boundary (MPB) dilemma in the KNN-LT-LS system, where it is shown that the origin of high piezoelectric activity is actually due to a polymorphic transition at room temperature. It is shown that prototype transducers based on pure and 1 mol% Ba2+ doped KNN-LT-LS exhibit performance metrics comparable to those fabricated using PZT-5H. Overall, KNNLT- LS ceramics show great promise for lead-free applications, although issues such as temperature dependence of properties and strong sensitivity to processing conditions remain as the 2 major challenges.
Understanding why we cannot model how long a code review will take: an industrial case study (2022)

Code review is an effective practice for finding defects, but because it is manually intensive it can slow down the continuous integration of changes. Our goal was to understand the factors that influenced the time a change, ie a diff at Meta, would spend in review. A developer survey showed that diff reviews start to feel slow after they have been waiting for around 24 hour review. We built a review time predictor model to identify potential factors that may be causing reviews to take longer, which we could use to predict when would be the best time to nudge reviewers or to identify diff-related factors that we may need to address.
A case for an SC-preserving compiler (2011)

The most intuitive memory consistency model for shared-memory multi-threaded programming is sequential consistency (SC). However, current concurrent programming languages support a relaxed model, as such relaxations are deemed necessary for enabling important optimizations. This paper demonstrates that an SC-preserving compiler, one that ensures that every SC behavior of a compiler-generated binary is an SC behavior of the source program, retains most of the performance benefits of an optimizing compiler. The key observation is that a large class of optimizations crucial for performance are either already SC-preserving or can be modified to preserve SC while retaining much of their effectiveness. An SC-preserving compiler, obtained by restricting the optimization phases in LLVM, a state-of-the-art C/C++ compiler, incurs an average slowdown of 3.8% and a maximum slowdown of 34% on a set of 30 programs from the SPLASH-2, PARSEC, and SPEC CINT2006 benchmark suites. While the performance overhead of preserving SC in the compiler is much less than previously assumed, it might still be unacceptable for certain applications. We believe there are several avenues for improving performance without giving up SC-preservation. In this vein, we observe that the overhead of our SC-preserving compiler arises mainly from its inability to aggressively perform a class of optimizations we identify as eager-load optimizations. This class includes common-subexpression elimination, constant propagation, global value numbering, and common cases of loop-invariant code motion. We propose a notion of interference checks in order to enable eager-load optimizations while preserving SC. Interference checks expose to the compiler a commonly used hardware speculation mechanism that can efficiently detect whether a particular variable has changed its value since last read.
RECURRENT INSTITUTIONAL OUTBREAKS OF ACUTE INFECTIOUS NONBACTERIAL GASTROENTERITIS: EPIDEMIOLOGY AND ETIOLOGY1 (1973)

Journal Article RECURRENT INSTITUTIONAL OUTBREAKS OF ACUTE INFECTIOUS NONBACTERIAL GASTROENTERITIS: EPIDEMIOLOGY AND ETIOLOGY Get access ROBERT F. BUSCHO, ROBERT F. BUSCHO Search for other works by this author on: Oxford Academic PubMed Google Scholar RICHARD G. WYATT, RICHARD G. WYATT 3Laboratory of Infectious Diseases, National Institutes of HealthBethesda, Md. 20014 Reprint requests to Dr. Wyatt. Bldg. 7, Rm. 105. Search for other works by this author on: Oxford Academic PubMed Google Scholar RAPHAEL DOLIN, RAPHAEL DOLIN Search for other works by this author on: Oxford Academic PubMed Google Scholar NEIL R. BLACKLOW, NEIL R. BLACKLOW Search for other works by this author on: Oxford Academic PubMed Google Scholar HERBERT L. DUPONT, HERBERT L. DUPONT 6Division of Infectious Diseases, University of Maryland School of MedicineBaltimore, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT M. CHANOCK ROBERT M. CHANOCK 3Laboratory of Infectious Diseases, National Institutes of HealthBethesda, Md. 20014 Reprint requests to Dr. Wyatt. Bldg. 7, Rm. 105. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 98, Issue 3, September 1973, Pages 192–198, https://doi.org/10.1093/oxfordjournals.aje.a121548 Published: 01 September 1973 Article history Received: 20 April 1973 Published: 01 September 1973
The Stabilities of N−Cl Bonds in Biocidal Materials (2006)

N-halamine chemistry has been a research topic of considerable importance in these laboratories for over two decades. N-halamine compounds are useful in preparing biocidal materials. There are three N-Cl moieties available in cyclic N-halamine compounds: imide, amide, and amine. The stabilities toward the release of free halogen have been experimentally shown to decrease in the order amine > amide > imide. In this work, this generalization has been tested theoretically at the level of B3LYP/6-31+G(d) and using the conductor-like polarizable continuum aqueous solvation model with UAKS cavities. Excellent accord was observed between theory and experiment. It was also found that the imide and amide N-halamine stabilities on hydantoin rings could be reversed with substitution patterns at the 5 position.
Treatment of hepatitis C virus infection (2007)

Acute and chronic hepatitis C virus (HCV) infection remains a serious health problem worldwide, however, there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin. The literature indicates that therapy for HCV is becoming more individualized. In addition to considering genotype and viral RNA levels before treatment, achievement of an early virologic response (EVR) and a rapid virologic response (RVR) is now possible during therapy. Moreover, problem patients, such as non-responders, relapsers, HIV or HBV co-infected patients, patients with liver cirrhosis, and pre- or post-liver transplantation patients are an increasing fraction of the patients requiring treatment. This article reviews the literature regarding standard treatments and problem patients with acute and chronic HCV infection. It also includes discussion on contraindications and side effects of treatment with interferon and ribavirin, as well as new drug development.
Evaluación de la estructura porosa de los materiales MCM-22, MCM-36 e ITQ-2 empleando el test catalitico del n-decano (2003)

N-DECANE CATALYTIC TEST. The void structure of zeolites MCM-22, MCM-36 and ITQ-2 were discussed on the bases of catalytic reaction tests. The hydromerization of n-decane on bifunctional Pt/Zeolite Catalysts have been used as model reactions. Beta and ZSM-5 zeolites were used for comparison. It is concluded that all materials show features of 10MR zeolites and have also pores bigger than 12MR in this order MCM-22<MCM-36<ITQ-2.
Effect of contaminants on the thermodynamic properties of CO2 -rich fluids and ramifications in the design of surface and injection facilities for geologic CO2 sequestration (2011)

Geologic storage may involve injection of impure carbon dioxide (CO2) streams in order to lower capture costs. The contaminants in the purified CO2 stream depend on the type of power plant and the capture scheme. For on oxy-fuel based combustion cycle, we have previously evaluated the effect of presence of oxygen, nitrogen and argon on the CO2 phase diagram and the critical properties of mixtures in these systems. For a 320 km pipeline, we established a base case for pure CO2, and evaluated the difference in compressor power requirements as each contaminant was added in fixed proportions. The key finding was that if the mixture encountered a two-phase region along the pipeline, the pressure drop becomes punitive. We proposed a minimal adjustment of operating conditions (or the temperature and pressure profile along the pipeline) to avoid the two-phase region and concomitant prohibitive pressure losses. In this paper, we consider the influence of hydrogen sulfide and water on the phase behavior of the CO2-rich captured stream. Specifically, we examine the phase equilibria and the PVT properties, and compare the GERG–2008 equation of state (EoS) computations with experimental data. In general, CO2-rich effluent mixtures from oxy-fuel plants may undergo phase separation at higher pressures than that for pure CO2 for the temperature range likely to be encountered in surface and injection facilities designed for CO2 sequestration. In addition, density, compressibility, and reactive properties of these mixtures may be significantly different from pure CO2. Consequently, operation of large geologic CO2 storage sites must anticipate how these differences in the thermodynamic properties of the injected fluids may affect compressor power requirements, pipeline transport, well design, and wellbore and reservoir integrity.
The Redistributed Chip Package: A Breakthrough for Advanced Packaging (2007)

The redistributed chip package (RCP) is a substrate-less embedded chip package that offers a low-cost, high performance, integrated alternative to current wirebond BGA and flip chip BGA packaging. Devices are encapsulated into panels while routing of signals, power, and ground is built directly on the panel. The RCP panel and signal build-up lowers the cost of the package by eliminating wafer bumping and substrates thereby enabling large scale assembly in panel form. The build-up provides better routing capabilities and better integration. Also, by eliminating bumping, the device interconnect is inherently Pb-free, and the stress of the package is reduced enabling ultra-low K device compatibility. The panel is created by attaching device active side down to a substrate, encapsulating and curing the devices, grinding to desired thickness, and then removing the substrate. Signal, power, and ground planes are created using redistribution-like processing. Multi-layer metal RCP packages have passed -40 to 125C air-to-air thermal cycling and HAST after MSL3/260 preconditioning.
Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway (2016)

It has been proposed that extracellular cGMP modulates the ability to learn a Y maze task, but the underlying mechanisms remained unknown. Here we show that extracellular cGMP, at physiological concentrations, modulates learning in the Y maze in a biphasic way by modulating the glutamate-nitric oxide-cGMP pathway in cerebellum. Extracellular cGMP reduces glycine receptors activation inducing a voltage-dependent calcium-channels-mediated increase of calcium in Purkinje neurons. This calcium increase modulates CaMKII phosphorylation in a biphasic way. When basal calcium concentration is low extracellular cGMP reduces CaMKII phosphorylation, increasing nitric oxide synthase activity, the glutamate-NO-cGMP pathway function and learning ability. When basal calcium is normal extracellular cGMP increases CaMKII phosphorylation, reducing nitric oxide synthase activity, the pathway function and learning. These data unveil new mechanisms modulating learning in the Y maze and likely other learning types which may be therapeutic targets to improve learning in pathological situations associated with altered cGMP levels.
Renormalization group for intermittency in area-preserving mappings (1982)

An exact solution is found for the functional renormalization-group equations describing intermittency in area-preserving mappings of the plane. Analysis of the solution yields two scaling laws for the duration of laminar flow in between chaotic bursts.
In-process gap reduction of capacitive transducers (2005)

This paper presents a MEMS fabrication technique for reducing the trench width of microstructures below the technological limitations of the deep reactive ion etching (DRIE) process, in order to increase the aspect ratio of the sensing electrode gap of capacitive transducers. The in-process trench width reduction is based on the displacement of a substructure actuated by a buckling beam mechanism. Compressive stress causes a longitudinal force in the acting beams which results in the buckling to a predefined direction. This way, the capacitive sensitivity and hence the signal to area ratio of a transverse comb structure could be increased by a factor of 5.
Comprehensive Postdoctoral Training Program in Breast Cancer Biology (2002)

Abstract : The goal of this training program is to significantly extend our existing, highly successful Doctoral Training Program in Tumor Biology and several Cancer Center mechanisms that provide traditional postdoctoral training and junior faculty career development. The program integrates faculty from the Lombardi Cancer Center programs in Cancer Prevention and Control and Cancer Genetics and makes use of the existing organizational structure of the Interdisciplinary Doctoral Training Program in Tumor Biology and incorporates a multi- disciplinary faculty who are devoted to research and education in breast cancer. We have one postdoctoral fellow who has successfully completer her fellowship in the program and another postdoctoral fellow who has successfully completed his first year and is now in his second year of research. We have recruited two postdoctoral fellows who have begun their first year of research in the program.
Observation of plasmonic field-enhancement of the nonlinear response of gold thin films (2008)

We investigate the nonlinear optical response of gold thin films of different thicknesses. Field enhancement effects lead to counterintuitive results which we interpret in terms of the excitation of plasmonic resonances at the metal-dielectric interfaces. © 2008 Optical Society of America.
High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension (2016)

Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline (MCT)-induced mild PAH. Six weeks of treadmill training (5 times/wk) were performed, as either 30 min HIIT or 60 min low-intensity CExT. To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 wk post-MCT using long-term implantable telemetry. MCT-induced decrement in maximal aerobic capacity was ameliorated by both HIIT and CExT, with less pronounced pulmonary vascular remodeling and no increase in RV inflammation or apoptosis observed. Most importantly, only HIIT lowered RV systolic pressure, RV hypertrophy, and total pulmonary resistance, and prompted higher cardiac index that was complemented by a RV increase in the positive inotrope apelin and reduced fibrosis. HIIT prompted a markedly pulsatile pulmonary pressure during running and was associated with greater lung endothelial nitric oxide synthase after 6 wk. We conclude that HIIT may be superior to CExT for improving hemodynamics and maladaptive RV hypertrophy in PAH. HIIT's superior outcomes may be explained by more favorable pulmonary vascular endothelial adaptation to the pulsatile HIIT stimulus.
Epstein-Barr Virus-Induced miR-155 Attenuates NF-κB Signaling and Stabilizes Latent Virus Persistence (2008)

MicroRNAs have been implicated in the modulation of gene expression programs important for normal and cancer cell development. miR-155 is known to play a role in B-cell development and is upregulated in various B-cell lymphomas, including several that are latently infected with Epstein-Barr virus (EBV). We show here that EBV infection of primary human B lymphocytes leads to the sustained elevation of miR-155 and its precursor RNA, BIC. The EBV-encoded latency membrane protein 1 (LMP1) can partially reconstitute BIC activation in B lymphocytes but not in epithelial cell cultures. LMP1 is a potent activator of NF-kappaB signaling pathways and is essential for EBV immortalization of B lymphocytes. An inhibitor to miR-155 further stimulated NF-kappaB responsive gene transcription, and IKKepsilon was identified as a potential target of miR-155 translational repression. Remarkably, miR-155 inhibitor reduced EBNA1 mRNA and the EBV copy number in latently infected cells. This suggests that miR-155 contributes to EBV immortalization by modulation of NF-kappaB signaling and the suppression of host innate immunity to latent viral infection.
A systematic review of charging infrastructure location problem for electric vehicles (2020)

With the evolving demand for sustainable mobility, adequate charging infrastructure for electric vehicles (EVs) has been growing steadily and wireless power transfer (WPT) technology has been seen as an efficient alternative for EV charging while maintaining seamless traffic flow. This paper reviews the modelling challenges in terms of both static (plug-in) charging (SC) and wireless charging (WC) facilities in a transportation network in terms of system integration, focusing on the evolution of the WPT technology. The first part of the paper provides an overview of all the major progress and achievements made by different research organisations in the area of WPT technology for EV charging. These technologies are ranked based on two indices, namely technological readiness level and system readiness level. The optimal location of WC facilities comes with more design and operational issues than conventional static charging facilities. However, they are similar in terms of the infrastructure modelling approach to locate these charging facilities, as the overall goal is to maximise the network flow and minimise the overall system cost. The second part of the paper assesses different modelling approaches used to analyse the network and locate the charging infrastructure for static and WC facilities. The economic feasibility of the technology is an important consideration for successful system integration as well as the overall performance of the system. As such, this paper also provides a synopsis of different socio-economic studies related to the WC infrastructure allocation problem. Finally, future research directions in this field are discussed based on the knowledge gaps identified from the existing literature.
On the Solution of Scatter Density in Geometry-Based Channel Models (2007)

Assuming a single bounce scattering geometric channel model with circularly symmetric scatter density we deduce a general integral relation between angle of arrival (AOA) and scatter density function. Then we show that this relation can be expressed in terms of an integral equation that admits an accurate numerical solution provided that AOA is known. Furthermore, we show that similar integral equation relation between time of arrival (TOA) and scatter density function can be efficiently solved numerically for a given TOA. Results indicate that the scatter density can be numerically computed for a given AOA or TOA. Since these marginal distributions can be directly fit in channel measurements, the method provides means to adjust the applied geometrical channel model through field measurements. Hence, we follow the idea of inverse scattering theory where the far field pattern of scattered waves is known and the aim is to define the structure of the scattering medium. We consider two example AOA distributions, Gaussian and Student's t-distribution, found in literature. Our results show that scatter densities as well as the corresponding TOAs greatly vary depending on the assumed AOA
Effects of dopants in InOx-based amorphous oxide semiconductors for thin-film transistor applications (2013)

Amorphous metal oxide thin-film transistors (TFTs) are fabricated using InOx-based semiconductors doped with TiO2, WO3, or SiO2. Even at low-dopant densities, the electrical properties of the film strongly depend on the dopant used. We found that this dependence could be reasonably explained by differences in the bond-dissociation energy of the dopants. By incorporating a dopant with a higher bond-dissociation energy, the film became less sensitive to the partial pressure of oxygen used during sputtering and remained electrically stable upon thermal annealing. Thus, choosing a dopant with an appropriate bond-dissociation energy is important when fabricating stable metal-oxide TFTs for flat-panel displays.
Systèmes de conversion des ressources énergétiques marines (2006)

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