gebhart/patrepeval huggingface dataset:
Predicting cardiothoracic voltages during high energy shocks: methodology and comparison of experimental to finite element model data (1995)

Finite element modeling has been used as a method to investigate the voltage distribution within the thorax during high energy shocks. However, there have been few quantitative methods developed to assess how well the calculations derived from the models correspond to measured voltages. In this paper, we present a methodology for recording thoracic voltages and the results of comparisons of these voltages to those predicted by finite element models. We constructed detailed 3-D subject-specific thorax models of six pigs based on their individual CT images. The models were correlated with the results of experiments conducted on the animals to measure the voltage distribution in the thorax at 52 locations during synchronized high energy shocks. One transthoracic and two transvenous electrode configurations were used in the study. The measured voltage values were compared to the model predictions resulting in a correlation coefficient of 0.927 +/- 0.036 (average +/- standard deviation) and a relative rms error of 22.13 +/- 5.99%. The model predictions of voltage gradient within the myocardium were also examined revealing differences in the percent of the myocardium above a threshold value for various electrode configurations and variability between individual animals. This variability reinforces the potential benefit of patient-specific modeling.
Opening of Epithelial Tight Junctions and Enhancement of Paracellular Permeation by Chitosan: Microscopic, Ultrastructural, and Computed-Tomographic Observations (2012)

This study investigates the effects of chitosan (CS) on the opening of epithelial tight junctions (TJs) and paracellular transport at microscopic, ultrastructural, and computed-tomographic levels in Caco-2 cell monolayers and animal models. Using immunofluorescence staining, CS treatment was observed to be associated with the translocation of JAM-1 (a trans-membrane TJ protein), resulting in the disruption of TJs; the removal of CS was accompanied by the recovery of JAM-1. Ultrastructural observations by TEM reveal that CS treatment slightly opened the apical intercellular space, allowing lanthanum (an electron-dense tracer) to stain the intercellular surface immediately beneath the TJs, suggesting the opening of TJs. Following the removal of CS, the TJs were completely recovered. Similar microscopic and ultrastructural findings were obtained in animal studies. CS nanoparticles were prepared as an insulin carrier. The in vivo fluorescence-microscopic results demonstrate that insulin could be absorbed into the systemic circulation, while most CS was retained in the microvilli scaffolds. These observations were verified in a biodistribution study following the oral administration of isotope-labeled nanoparticles by single-photon emission computed tomography. Above results reveal that CS is a safe permeation enhancer and is an effective carrier for oral protein delivery.
Erratum to: Predicting Solid–Liquid Equilibrium of Fatty Acid Methyl Ester and Monoglyceride Mixtures as Biodiesel Model Fuels (2017)

In the original article, the incorrect version of Table 3 was published. The correct version of Table 3 should appear as follows:
Persistent luminescence in ZnGa2O4:Cr: an outstanding biomarker forin-vivoimaging (2014)

ZnGa<sub>2</sub>O<sub>4</sub> (ZGO) is a normal spinel. When doped with Cr<sup>3+</sup> ions, ZGO:Cr becomes a high brightness persistent luminescence material with an emission spectrum perfectly matching the transparency window of living tissues. It allows <i>in vivo</i> mouse imaging with a better signal to background ratio than classical fluorescent NIR probes. The most interesting characteristic of ZGO:Cr lies in the fact that its LLP can be excited with red light, well below its band gap energy and in the transparency window of living tissues. A mechanism based on the trapping of carriers localized around a special type of Cr<sup>3+</sup> ions namely Cr<sub>N2</sub> can explain this singularity. The antisite defects of the structure are the main responsible traps in the persistent luminescence mechanism. When located around Cr<sup>3+</sup> ions, they allow, via Cr<sup>3+</sup> absorption, the storage of not only UV light but also all visible light from the excitation source.
Optimal Design of Outer Rotor Switched Reluctance Machines for Direct Drive Rim Applications (2018)

This paper discusses the optimal design of external rotor switched reluctance (SR) machines for direct drive applications. The machines considered for this study include SR motors with a higher number of rotor poles than stator teeth; machines employing a larger number of stator teeth than rotor poles, as well as machines with segmented rotor constructions. Differential evolution is utilized for the optimization, and two objectives, of mass and loss are considered. A comprehensive comparison of the mass, loss, and inverter VA rating required to meet target torque for all three studied machine was performed, in which, hundreds of candidate designs were analyzed. The calculations are also benchmarked with results from a prototype motor.
Axial dissymmetry induced magnetic nonequivalence in the 13C nuclear magnetic resonance spectra of allenes (1980)

not available
ChemInform Abstract: An Efficient Process for Pd‐Catalyzed C—N Cross‐Coupling Reactions of Aryl Iodides: Insight into Controlling Factors. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reproductive biology of Coilia mystus (Linnaeus) from the Yangtze Estuary, China: responses to overexploitation (2011)

Fishery harvest of Coilia mystus in the Yangtze Estuary has declined dramatically since the late 1990s. A full understanding of the reproductive biology of this species is essential for effective management of the population. A total of 1072 females of C. mystus collected from the Yangtze Estuary area between May 2006 and September 2007 were analyzed to reveal the general reproductive biology of the population. Females with increased gonadosomatic index (GSI) and gonads developed to stages IV and V occurred mainly from March through August, indicating a major spawning season in this period; there were also a few females with increased GSI and developed gonads observed in November and January. Absolute fecundity (AF) ranged from 3093 to 36 786; and increased with both body weight (BW) and age. The relationship of AF to BW was fitted to a linear function AF = 924.72 × BW−414.17 (r2 = 0.82, n = 134, P < 0.05). Relative fecundity was 871 eggs per gram. Oocyte diameter (OD) of mature females ranged from 0.55 to 0.90 mm with a mean (±SD) of 0.71 ± 0.05 mm (n = 3927), independent of BW. The frequency distribution of OD showed a single mode and histological examination demonstrated that the development of oocytes was synchronous within an ovary, suggesting that C. mystus is a single spawner. Compared to previous studies, females in this study tended to produce more but smaller eggs. This increased fecundity may represent biological compensation for the decline in abundance of the population due to overexploitation.
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling (2014)

In phagocytic cells, including the retinal pigment epithelium (RPE), acidic compartments of the endolysosomal system are regulators of both phagocytosis and autophagy, thereby helping to maintain cellular homeostasis. The acidification of the endolysosomal system is modulated by a proton pump, the V-ATPase, but the mechanisms that direct the activity of the V-ATPase remain elusive. We found that in RPE cells, CRYBA1/βA3/A1-crystallin, a lens protein also expressed in RPE, is localized to lysosomes, where it regulates endolysosomal acidification by modulating the V-ATPase, thereby controlling both phagocytosis and autophagy. We demonstrated that CRYBA1 coimmunoprecipitates with the ATP6V0A1/V0-ATPase a1 subunit. Interestingly, in mice when Cryba1 (the gene encoding both the βA3- and βA1-crystallin forms) is knocked out specifically in RPE, V-ATPase activity is decreased and lysosomal pH is elevated, while cathepsin D (CTSD) activity is decreased. Fundus photographs of these Cryba1 conditional knockout (cKO) mice showed scattered lesions by 4 months of age that increased in older mice, with accumulation of lipid-droplets as determined by immunohistochemistry. Transmission electron microscopy (TEM) of cryba1 cKO mice revealed vacuole-like structures with partially degraded cellular organelles, undigested photoreceptor outer segments and accumulation of autophagosomes. Further, following autophagy induction both in vivo and in vitro, phospho-AKT and phospho-RPTOR/Raptor decrease, while pMTOR increases in RPE cells, inhibiting autophagy and AKT-MTORC1 signaling. Impaired lysosomal clearance in the RPE of the cryba1 cKO mice also resulted in abnormalities in retinal function that increased with age, as demonstrated by electroretinography. Our findings suggest that loss of CRYBA1 causes lysosomal dysregulation leading to the impairment of both autophagy and phagocytosis.
Co-Design of Multi-Band High-Efficiency Power Amplifier and Three-Pole High-$Q$ Tunable Filter (2013)

This letter reports a novel methodology for co-design of broadband power amplifiers (PAs) and high- Q tunable filters. It is for the first time demonstrated that the tunable filter's input port can be synthesized to directly match the transistor's output, thus eliminating the conventional broadband/band-reconfigurable matching network of the PA. This leads to minimized circuit size, volume, and loss. In this letter, a three-pole tunable bandpass filter is designed as the output matching network of a 10 W GaN PA, yielding optimal fundamental and harmonic impedances. Simulation and measured results show that the co-designed PA-filter module exhibits desired Chybeshev filter behavior while achieving efficient PA performance in the passband over a 400-MHz tuning range from 2.95-3.35 GHz. Specifically, 51%-67% efficiency, ≈ 10 W output power, ≈ 10 dB gain were measured throughout the entire frequency range.
Kaolin‐activated thromboelastography and standard coagulation assays in cyanotic and acyanotic infants undergoing complex cardiac surgery: a prospective cohort study (2016)

According to our findings, cyanosis does not affect TEG parameters in children with CHD. PLT count and plasma fibrinogen significantly correlated (are significantly associated) with MA and MA-fib respectively, suggesting that use of TEG after protamine administration may be prompted for improved hemostatic monitoring in the perioperative phase.
Weighted Maximum Posterior Marginals for Random Fields Using an Ensemble of Conditional Densities From Multiple Markov Chain Monte Carlo Simulations (2011)

The ability of classification systems to adjust their performance (sensitivity/specificity) is essential for tasks in which certain errors are more significant than others. For example, mislabeling cancerous lesions as benign is typically more detrimental than mislabeling benign lesions as cancerous. Unfortunately, methods for modifying the performance of Markov random field (MRF) based classifiers are noticeably absent from the literature, and thus most such systems restrict their performance to a single, static operating point (a paired sensitivity/specificity). To address this deficiency we present weighted maximum posterior marginals (WMPM) estimation, an extension of maximum posterior marginals (MPM) estimation. Whereas the MPM cost function penalizes each error equally, the WMPM cost function allows misclassifications associated with certain classes to be weighted more heavily than others. This creates a preference for specific classes, and consequently a means for adjusting classifier performance. Realizing WMPM estimation (like MPM estimation) requires estimates of the posterior marginal distributions. The most prevalent means for estimating these--proposed by Marroquin--utilizes a Markov chain Monte Carlo (MCMC) method. Though Marroquin's method (M-MCMC) yields estimates that are sufficiently accurate for MPM estimation, they are inadequate for WMPM. To more accurately estimate the posterior marginals we present an equally simple, but more effective extension of the MCMC method (E-MCMC). Assuming an identical number of iterations, E-MCMC as compared to M-MCMC yields estimates with higher fidelity, thereby 1) allowing a far greater number and diversity of operating points and 2) improving overall classifier performance. To illustrate the utility of WMPM and compare the efficacies of M-MCMC and E-MCMC, we integrate them into our MRF-based classification system for detecting cancerous glands in (whole-mount or quarter) histological sections of the prostate.
[The antigenic interrelationships between influenza A (H2) viruses determined by the mathematical processing of the data from immunoenzyme analysis using monoclonal antibodies to the M1 and NP proteins]. (1992)

Antigenic relationships among 15 influenza A (H2) virus strains of human and avian origin were determined by ELISA titers with monoclonal antibodies (MCA) to Ml and NP proteins. Minor antigenic variations were found in Ml protein. One MCA to NP protein (469/6) showed different reactivity with human and avian influenza viruses. Analyses of antigenic relationships among influenza viruses were performed according to a computerized taxonomic cluster procedure. The evolutionary relatedness of these viruses is discussed.
Immediate Discharge and Home Treatment With Rivaroxaban of Low‐risk Venous Thromboembolism Diagnosed in Two U.S. Emergency Departments: A One‐year Preplanned Analysis (2015)

Patients diagnosed with VTE and immediately discharged from the ED while treated with rivaroxaban had a low rate of VTE recurrence and bleeding.
The human telomeric proteome during telomere replication (2021)

Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of telomeric DNA repeats. To investigate telomere replication in a comprehensive manner, we develop QTIP-iPOND - Quantitative Telomeric chromatin Isolation Protocol followed by isolation of Proteins On Nascent DNA - which enables purification of proteins that associate with telomeres specifically during replication. In addition to the core replisome, we identify a large number of proteins that specifically associate with telomere replication forks. Depletion of several of these proteins induces telomere fragility validating their importance for telomere replication. We also find that at telomere replication forks the single strand telomere binding protein POT1 is depleted, whereas histone H1 is enriched. Our work reveals the dynamic changes of the telomeric proteome during replication, providing a valuable resource of telomere replication proteins. To our knowledge, this is the first study that examines the replisome at a specific region of the genome.
Synthesis of Kappa Light Chains by Cell Lines Containing an 8;22 Chromosomal Translocation Derived from a Male Homosexual with Burkitt's Lymphoma (1983)

Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.
SRv6 vSID: Network Programming extension for variable length SIDs (2020)

This document proposes an extension to Segment Routing IPv6 (SRv6)
Network Programming to allow for SRv6 Segment Identifier (SID) of
smaller variable length. The use of smaller SRv6 SID reduces the size
the SRv6 Header (SRH). This reduces the overhead for both the traffic
volume and the network processor. It is a straightforward extension to
the SRv6 Network Programming model and its SRH encapsulation.
WALT: Watch And Learn 2D amodal representation from Time-lapse imagery (2022)

Current methods for object detection, segmentation, and tracking fail in the presence of severe occlusions in busy urban environments. Labeled real data of occlusions is scarce (even in large datasets) and synthetic data leaves a domain gap, making it hard to explicitly model and learn occlusions. In this work, we present the best of both the real and synthetic worlds for automatic occlusion supervision using a large readily available source of data: time-lapse imagery from stationary webcams observing street intersections over weeks, months, or even years. We introduce a new dataset, Watch and Learn Time-lapse (WALT), consisting of 12 (4K and 1080p) cameras capturing urban environments over a year. We exploit this real data in a novel way to automatically mine a large set of unoccluded objects and then composite them in the same views to generate occlusions. This longitudinal self-supervision is strong enough for an amodal network to learn object-occluder-occluded layer representations. We show how to speed up the discovery of unoccluded objects and relate the confidence in this discovery to the rate and accuracy of training occluded objects. After watching and automatically learning for several days, this approach shows significant performance improvement in detecting and segmenting occluded people and vehicles, over human-supervised amodal approaches.
Cystosarcoma Phyllodes Metastatic to a Brenner Tumor of the Ovary (1976)

A patient had cytosarcoma phyllodes that developed metastases to bone and to a Brenner tumor of the ovary. The original breast tumor was reported as benign, but the patient died of metastases four months following mastectomy. The rapid growth in the ovary may have been due to estrogenic stroma in the Brenner tumor. This is the first report, to our knowledge, of cystosarcoma phyllodes metastasizing to another tumor.
Tribological Study of Ti3SiC2 and Its Derivatives (2005)

In this paper, we report on the tribological and wear properties of Ti3SiC2 and its derivatives. Coarse-grained Ti3SiC2 was not wear resistant at room temperature. Preoxidation of the material at 700 °C for 5 h also failed to ameliorate the situation at room temperature. Addition of 20 vol.% Cu in the matrix improved the wear rate for up to 1500 m; beyond that distance the friction and wear increased. Ti3SiC2 tested at 500 °C showed improved wear resistance most probably due to the formation of oxide tribofilms. More work is being done to understand the basic mechanism behind this behavior.
Role of Chymotrypsin-like Elastase 1 in Lung Physiology and in α1-Antitrypsin Deficiency (2017)

Abstract α1-antitrypsin related lung disease (AAT-RLD) is the fourth leading indication for lung transplantation and is characterized by protease-mediated progressive emphysema that manifests in the 4 th or 5 th decade of life. Chymotrypsin-like elastase 1 ( Cela1 ) is a digestive enzyme that binds to elastin in a stretch-dependent manner and is covalently neutralized by AAT. We hypothesized a role for Cela1 in AAT-RLD. Cela1 -/- mice where phenotypically similar to wild type but had higher lung elastance and lacked stretch-inducible elastase activity. Wild-type mice administered anti-AAT oligo had reduced amounts of lung Cela1-AAT fusion protein in lung homogenate and spontaneously developed emphysema after 6 weeks. Cela1 -/- mice administered anti-AAT oligo were completely protected from these emphysematous changes. Cela1 recombinant protein did not require propeptide cleavage for elastolysis, and its elastolytic profile was similar to that of other pancreatic elastases. Phylogenetic analysis of vertebrate Cela promoter and protein sequences showed that placental mammal Cela1 was distinct from other Cela’s , and that the placental mammal the Cela1 gene was invariantly conserved despite variable loss of other Cela genes in non-carnivores. These data demonstrate that the pancreatic enzyme Cela1 has been evolutionarily co-opted for a role in reducing lung elastance in the placental mammal lineage and that its stretch-regulated expression and elastolytic activity is responsible for emphysema in the absence of its anti-protease: AAT.
YULINK regulates vascular formation in zebrafish and HUVECs (2023)

This study suggests that YULINK regulates vasculogenesis, possibly through endocytosis in zebrafish and HUVECs.
Kristall‐Engineering bei Melamin‐Imid‐Komplexen: Beeinflussung der Stöchiometrie durch sterische Hinderung an den Imid‐Carbonylgruppen (1997)

Ein definiertes Melamin‐Imid‐Verhältnis in Komplexen kann durch Änderung der sterischen Gegebenheiten an den Wasserstoffbrücken‐Acceptorstellen der Imide eingestellt werden. So werden kristalline 1:1‐, 1:2‐ und 1:3‐Komplexe von Melamin mit Succinimid, Glutarsäureimid bzw. 1‐ N ‐Propylthymin (siehe rechts) gebildet. magnified image
Curatr: a web application for creating, curating, and sharing a mass spectral library (2017)

Abstract Motivation Identification from metabolomics mass spectrometry experiments requires comparison of fragmentation spectra from experimental samples to spectra from analytical standards. As the quality of identification depends directly on the quality of the reference spectra, manual curation is routine during the selection of reference spectra to include in a spectral library. Whilst building our own in-house spectral library we realised that there is currently no vendor neutral open access tool for for facilitating manual curation of spectra from raw LC-MS data into a custom spectral library. Results We developed a web application curatr for the rapid generation of high quality mass spectral fragmentation libraries for liquid-chromatography mass spectrometry analysis. Curatr handles datasets from single or multiplexed standards, automatically extracting chromatographic profiles and potential fragmentation spectra for multiple adducts. These are presented through an intuitive interface for manual curation before being documented in a custom spectral library. Searchable molecular information and the providence of each standard is stored along with metadata on the experimental protocol. Curatr support the export of spectral libraries in several standard formats for easy use with third party software or submission to community databases, maximising the return on investment for these costly measurements. We demonstrate the use of curatr to generate the EMBL Metabolomics Core Facility spectral library which is publicly available at http://curatr.mcf.embl.de . Availability The source code is freely available at http://github.com/alexandrovteam/curatr/ along with example data. Supplementary information A step-by step user manual is available in the supplementary information