gebhart/patrepeval huggingface dataset:
Directly copolymerized poly(arylene sulfide sulfone) disulfonated copolymers for PEM‐based fuel cell systems. I. Synthesis and characterization (2005)

Abstract Direct aromatic nucleophilic substitution polycondensations of disodium 3,3′‐disulfonate‐4,4′‐difluorodiphenylsulfone (SDFDPS), 4,4′‐difluorodiphenylsulfone (DFDPS) (or their chlorinated analogs), and 4,4′‐thiobisbenzenethiol in the presence of potassium carbonate were investigated. Electrophilic aromatic substitution was employed to synthesize the SDFDPS comonomer in high yields and purity. High molecular weight disulfonated copolymers were easily obtained using the SDFDPS monomers, but in general, slower rates and a lower molecular weight copolymer were obtained using the analogous chlorinated monomers. Tough and ductile membranes were solution cast from N , N ‐dimethylacetamide for both series of copolymers. The degrees of disulfonation (20–50%) were controlled by varying the ratio of disulfonated to unsulfonated comonomers. Precise control of the ionic concentration, well‐defined ionic locations, and enhanced stability due to the deactivated position of the –SO 3 H group are some of the suggested advantages of direct copolymerization of sulfonated monomers. Further publications will discuss additional characteristics of these copolymers that have the same repeat unit, but different molecular weights, using methanol permeability, water uptake, protonic conductivity, and dynamic mechanical analysis. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 2964‐2976, 2005
Reactive Silver Oxalate Ink Composition with Enhanced Curing Conditions for Flexible Substrates (2018)

A solid silver-ligand complex, μ-oxolato-bis(ethylenediaminesilver(I)), was developed for formulating particle-free conductive metal-organic decomposition (MOD) inkjet inks. The complex comprises both a high molar silver content and solubility in inkjet compatible polar solvents. An aqueous ink formulation with 29.5 wt % silver content was developed and inkjet printed onto glass, polyethylene terephthalate, and polyimide substrates. A new hybrid thermal-photonic curing approach resulting in substantially improved electrical properties and substrate adhesion is presented. Silver conductive traces were measured to have bulk resistivity of 4.26 × 10<sup>-8</sup> Ω m, which is 2.7 times that of bulk silver. One-pot complex synthesis yielded an easily isolated, and stable, solid product that can be formulated when needed thereby improving shelf life.
Rationally designed mariner vectors for functional genomic analysis of Actinobacillus pleuropneumoniae and other Pasteurellaceae species by transposon-directed insertion-site sequencing (TraDIS) (2021)

Comprehensive identification of conditionally essential genes requires efficient tools for generating high-density transposon libraries that, ideally, can be analysed using next-generation sequencing methods such as Transposon Directed Insertion-site Sequencing (TraDIS). The <i>Himar1</i> (<i>mariner</i>) transposon is ideal for generating near-saturating mutant libraries, especially in AT-rich chromosomes, as the requirement for integration is a TA dinucleotide, and this transposon has been used for mutagenesis of a wide variety of bacteria. However, plasmids for <i>mariner</i> delivery do not necessarily work well in all bacteria. In particular, there are limited tools for functional genomic analysis of <i>Pasteurellaceae</i> species of major veterinary importance, such as swine and cattle pathogens, <i>Actinobacillus pleuropneumoniae</i> and <i>Pasteurella multocida</i>, respectively. Here, we developed plasmids, pTsodCPC9 and pTlacPC9 (differing only in the promoter driving expression of the transposase gene), that allow delivery of <i>mariner</i> into both these pathogens, but which should also be applicable to a wider range of bacteria. Using the pTlacPC9 vector, we have generated, for the first time, saturating <i>mariner</i> mutant libraries in both <i>A. pleuropneumoniae</i> and <i>P. multocida</i> that showed a near random distribution of insertions around the respective chromosomes as detected by TraDIS. A preliminary screen of 5000 mutants each identified 8 and 14 genes, respectively, that are required for growth under anaerobic conditions. Future high-throughput screening of the generated libraries will facilitate identification of mutants required for growth under different conditions, including <i>in vivo</i>, highlighting key virulence factors and pathways that can be exploited for development of novel therapeutics and vaccines.
Low cost high efficiency power generation (2009)

This paper presents a high efficiency power generation system using a low cost synchronous rectification scheme for an active MOSFET rectifier. The proposed system not only improves the efficiency by 5 percentage points and increases the output power by 12% at engine idle speed, but also has minimal impact on the overall package size of the generator, making it very suitable for production. The generator control concept is simulated and then verified on a proof-of-concept system built and tested in the lab.
Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies. (2006)

This is the first report of the combined modality treatment using antisense oligonucleotides with radiation therapy in patients with advanced cancer. A dose of 2.0 mg/kg of LErafAON administered twice weekly is tolerated with premedication and does not enhance radiation toxicity in patients. The observation of dose-dependent, infusion-related reactions has led to further modification of the liposomal composition for use in future clinical trials.
Sidewall gated double well quasi-one-dimensional resonant tunneling transistors (1997)

We present gating characteristics of submicron vertical resonant tunneling transistors in double quantum well heterostructures. Current–voltage characteristics at room temperature and 77 K for devices with minimum feature widths of 0.9 and 0.7 μm are presented and discussed. The evolution of the I–V characteristics with increasing negative gate biases is related to the change in the lateral confinement, with a transition from a large area 2D to a quasi-1D. Even gating of multiple wells and lateral confinement effects observable at 77 K make these devices ideally suited for applications in multi-valued logic systems and low-dimensional structures.
<title>Ultralow phase noise compact-sized X-band optoelectronic oscillator</title> (1999)

We report the performance of an optoelectronic oscillator (OEO) constructed with a DFB laser, a semiconductor Mach- Zehnder modulator, and a dielectric resonator based RF filter. We achieved a phase noise of -50 dBc/Hz at 10 Hz and -130 dBc/Hz at 10 kHz from a 10 GHz oscillation frequency, a performance comparable with that of an OEO constructed with a diode-pump YAG laser and a LiNbO3 modulator. The demonstration proves the feasibility of a high performance, low cost, and compact OEO.
Impact of an Anticaries Mouthrinse onIn VitroRemineralization and Microbial Control (2014)

Objective. The objective of this research was to evaluate the caries control potential of a new fluoride mouthrinse that also contained antimicrobial agents and a biofilm disrupting agent using different in vitro models. Methods. Four in vitro studies were conducted to assess the performance of this three pronged approach to caries control: (1) traditional enamel fluoride uptake, (2) surface microhardness study using pH cycling model and subsequent fluoride uptake, (3) a salivary biofilm flow-through study to determine the anti-microbial activity, and (4) a single species biofilm model measuring effect on biofilm matrix disruption. Results. The data showed that a LISTERINE rinse with fluoride, essential oils and xylitol was superior in promoting enamel fluoride uptake and in enhancing antimicrobial activity over traditional commercially available fluoridated products. An increase of the surface microhardness was observed when the LISTERINE rinse was used in combination with fluoridated toothpaste versus the fluoridated toothpaste alone. Finally, it was demonstrated that xylitol solutions disrupted and reduced the biovolume of biofilm matrix of mature Streptococcus mutans. Conclusion. These in vitro studies demonstrated that a fluoride mouthrinse with antimicrobial agent and biofilm matrix disrupting agent provided multifaceted and enhanced anti-caries efficacy by promoting remineralization, reducing acidogenic bacteria and disrupting biofilm matrix.
Strong hot electron reflection from subsurface 8H-SiC inclusion in 4H-SiC: Ballistic Electron Emission Microscopy (BEEM) study (2010)

The electrical properties of planar 8H stacking-fault inclusions (SFIs) formed during epilayer growth on an 8 degree miscut n-type 4H-SiC substrate were characterized using nm-resolution BEEM. A ???0.39 eV lower Schottky barrier was measured along the line where the SFI intersect a Pt metal overlayer, confirming that 8H SFIs are electron quantum wells (QWs). Interestingly, an asymmetry of the BEEM current amplitude was observed around the intersection line, which is believed to be caused by strong hot electron reflection from the subsurface 8H inclusion. We will discuss our modeling to explain this strong hot electron reflection and the lower bound of hot electron attenuation length in 4H-SiC estimated from the measured BEEM current profile. Work supported by ONR.
Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α (2008)

Growing evidence suggests that NADPH oxidase (Nox)-derived reactive oxygen species (ROS) play important roles in regulating cytokine signaling. We have explored how TNF-alpha induction of Nox-dependent ROS influences NF-kappaB activation. Cellular stimulation by TNF-alpha induced NADPH-dependent superoxide production in the endosomal compartment, and this ROS was required for IKK-mediated activation of NF-kappaB. Inhibiting endocytosis reduced the ability of TNF-alpha to induce both NADPH-dependent endosomal superoxide and NF-kappaB, supporting the notion that redox-dependent signaling of the receptor occurs in the endosome. Molecular analyses demonstrated that endosomal H(2)O(2) was critical for the recruitment of TRAF2 to the TNFR1/TRADD complex after endocytosis. Studies using both Nox2 siRNA and Nox2-knockout primary fibroblasts indicated that Nox2 was critical for TNF-alpha-mediated induction of endosomal superoxide. Redox-active endosomes that form after TNF-alpha or IL-1 beta induction recruit several common proteins (Rac1, Nox2, p67(phox), SOD1), while also retaining specificity for ligand-activated receptor effectors. Our studies suggest that TNF-alpha and IL-1 beta signaling pathways both can use Nox2 to facilitate redox activation of their respective receptors at the endosomal level by promoting the redox-dependent recruitment of TRAFs. These studies help to explain how cellular compartmentalization of redox signals can be used to direct receptor activation from the plasma membrane.
Doubly-dendronized linear polymers (2005)

Doubly-dendronized polymers were synthesized by grafting polybenzyl ether dendrons onto a poly(hydroxy) styrene polymer with polyaliphatic esters.
Data from Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands (2023)

&lt;div&gt;Abstract&lt;p&gt;Evasion of death receptor ligand–induced apoptosis represents an important contributor to cancer development and progression. Therefore, molecules that restore sensitivity to death receptor stimuli would be important tools to better understand this biological pathway and potential leads for therapeutic adjuncts. Previously, the small-molecule 4-(4-chloro-2-methylphenoxy)-&lt;i&gt;N&lt;/i&gt;-hydroxybutanamide (that we propose be named droxinostat) was identified as a chemical sensitizer to death receptor stimuli, decreasing the expression of the caspase-8 inhibitor FLIP. However, the direct targets of droxinostat were unknown. To better understand the mechanism of action of droxinostat and highlight new strategies to restore sensitivity to death receptor ligands, we analyzed changes in gene expression using the Connectivity Map after treating cells with droxinostat. Changes in gene expression after droxinostat treatment resembled changes observed after treatment with histone deacetylase (HDAC) inhibitors. Therefore, we examined the effects of droxinostat on HDAC activity and showed that it selectively inhibited HDAC3, HDAC6, and HDAC8 and that inhibition of these HDACs was functionally important for its ability to sensitize cells to death ligands. Thus, we have identified a selective HDAC inhibitor and showed that selective HDAC inhibition sensitizes cells to death ligands, thereby highlighting a new mechanism to overcome resistance to death receptor ligands. Mol Cancer Ther; 9(1); 246–56&lt;/p&gt;&lt;/div&gt;
Postoperative analgesia for early extubation after cardiac surgery. A prospective, randomized trial. (1999)

Tramadol and ketorolac seem to be the best options for treating postoperative pain in the specific setting of early extubation after cardiac surgery; high doses of tramadol may result in a significant even if clinically not relevant respiratory depression.
1-Arylsulfonylhydrazides. III. 4-Phenyl-1-arylsulfonylthiosemicarbazides and 2-arylsulfonylhydrazone-3-phenyl-4-thiazolines (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Arylsulfonylhydrazides. III. 4-Phenyl-1-arylsulfonylthiosemicarbazides and 2-arylsulfonylhydrazone-3-phenyl-4-thiazolinesCarlos. Sunkel and Humberto. GomezCite this: J. Med. Chem. 1970, 13, 2, 334–335Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/jm00296a056https://doi.org/10.1021/jm00296a056research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Addressing different active neutron interrogation signatures from fissionable material (2009)

In a continuing effort to examine portable methods for implementing active neutron interrogation for detecting shielded fissionable material research is underway to investigate the utility of analyzing multiple time-correlated signatures. Time correlation refers here to the existence of unique characteristics of the fission interrogation signature related to the start and end of an irradiation, as well as signatures present in between individual pulses of an irradiating source. Traditional measurement approaches in this area have typically worked to detect die-away neutrons after the end of each pulse, neutrons in between pulses related to the decay of neutron emitting fission products, or neutrons or gamma rays related to the decay of neutron emitting fission products after the end of an irradiation exposure. In this paper we discus the potential weaknesses of assessing only one signature versus multiple signatures and make the assertion that multiple complimentary and orthogonal measurements should be used to bolster the performance of active interrogation systems, helping to minimize susceptibility to the weaknesses of individual signatures on their own. Recognizing that the problem of detection is a problem of low count rates, we are exploring methods to integrate commonly used signatures with rarely used signatures to improve detection capabilities for these measurements. In this paper we will discuss initial activity in this area with this approach together with observations of some of the strengths and weaknesses of using these different signatures.
Suppressing the sample-to-sample variation of photonic crystal nanocavity Q-factors by air-hole patterns with broken mirror symmetry (2023)

It is known that the quality factors (Q) of photonic crystal nanocavities vary from sample to sample due to air-hole fabrication fluctuations. In other words, for the mass production of a cavity with a given design, we need to consider that the Q can vary significantly. So far, we have studied the sample-to-sample variation in Q for symmetric nanocavity designs, that is, nanocavity designs where the positions of the holes maintain mirror symmetry with respect to both symmetry axes of the nanocavity. Here we investigate the variation of Q for a nanocavity design in which the air-hole pattern has no mirror symmetry (a so-called asymmetric cavity design). First, an asymmetric cavity design with a Q of about 250,000 was developed by machine learning using neural networks, and then we fabricated fifty cavities with the same design. We also fabricated fifty symmetric cavities with a design Q of about 250,000 for comparison. The variation of the measured Q values of the asymmetric cavities was 39% smaller than that of the symmetric cavities. This result is consistent with simulations in which the air-hole positions and radii are randomly varied. Asymmetric nanocavity designs may be useful for mass production since the variation in Q is suppressed.
Looking Ahead for Resistive Memory Technology: A broad perspective on ReRAM technology for future storage and computing (2016)

Resistive random-access memory (ReRAM) is regarded as one of the most promising alternative nonvolatile memory technologies for its advantages in very-high-storage density, simple structure, low power consumption, and long endurance, as well as good compatibility with traditional complimentary metal-oxide-semiconductor (CMOS) technology. In addition to the data storage, ReRAM can also be used for logic operation and computation, demonstrating a great potential in developing a non-von Neumann computing system. Extensive studies on ReRAM technology, including material, device process, cell and array structure, circuit, and architecture, have been conducted in recent years. In this article, we provide a broad perspective on ReRAM technology for future storage and computing. The models, challenges, and applications are also summarized.
Scope and Limitations of Sodium and Potassium Trimethylsilanolate as Reagents for Conversion of Esters to Carboxylic Acids (2007)

Sodium or potassium trimethylsilanolate act as versatile and very powerful reagents for conversion of a wide variety of esters to carboxylic acids. The reactions were performed in tetrahydrofuran under mild reaction conditions with high to quantitative yields.
Controlling Infectious Diseases through Vaccination (2014)

Infectious diseases continue to cause significant morbidity and mortality in both animals and humans. Indeed, every year infectious diseases cost the global economy billions of dollars in losses and are responsible for approximately one-third of all human deaths. These deaths occur from routine infections, hospital acquired infections (approximately 100,000 deaths occur annually in North America due to hospital-acquired infections), occasional pandemics or regional outbreaks. The most recent regional outbreak is Ebola in West Africa. This infection has caused significant challenges for the regional health care community and has had a global impact. The challenge in the control of infectious diseases is not only due to routine infections but also to the continued emergence and re-emergence of infectious diseases. These new threats occur on a regular basis with approximately thirty new emerging or re-emerging diseases recorded in the last thirty years. The majority of these emerging diseases are zoonotic (over 70%) causing even greater challenges to their control in humans and animals.
ChemInform Abstract: Synthesis and Activity Studies of N‐[ω‐N′‐(Adamant‐1′‐yl)aminoalkyl] ‐2‐(4′‐dimethylaminophenyl)acetamides: In the Search of Selective Inhibitors for the Different Molecular Forms of Acetylcholinesterase. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Guest Editorial Circuits and Systems for Smart Agriculture and Healthy Foods (2021)

This Special Issue of the IEEE Journal on Emerging and Selected Topics in Circuits and Systems (JETCAS) is dedicated to circuits and systems applied to innovative products for the agriculture and food value chain.
Digitized Film Radiography (1989)

COOK, LARRY T. PhD*; GIGER, MARYELLEN LISSAK PhD†; WETZEL, LOUIS H. MD*; MURPHEY, MARK D. MD*; BATNITZKY, SOLOMON MD* Author Information
Totalsynthese von Altohyrtin A (Spongistatin 1): Teil 1 (1998)

Außerordentlich cytotoxisch sind die aus Meeresschwämmen isolierten Spongipyrane. Sie wirken gegen mehrere menschliche Krebszellinien, wobei das als erste Verbindung dieser Naturstoffklasse isolierte Spongistatin 1 am wirksamsten ist. Die erste Totalsynthese dieses Makrolids wurde nun abgeschlossen. Durch sie wird die von Kitagawa et al. vorgeschlagene relative und absolute Konfiguration bestätigt und nachgewiesen, daß Altohyrtin A und Spongistatin 1 identisch sind.
Antimicrobial Activity and Chemical Composition of Callistemon Comboynensis and C. Citrinus Leaf Essential Oils from the Northern Plains of India (2008)

Biological and chemical investigations were carried out to evaluate the antimicrobial potential of Callistemon comboynensis and C. citrinus leaf oils for herbal medicines. Disk diffusion and micro broth dilution methods were used for the evaluation of the antimicrobial activity of the essential oils against selected strains of bacteria (Staphylococcus aureus, S. epidermidis, Streptococcus mutans, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter aerogenes and Escherichia coli) and fungi (Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Aspergillus flavus, A. niger and Sporothrix schenckii). Analysis of the leaf essential oils of C. comboynensis and C. citrinus using GC and GC-MS resulted in the identification of thirty and twenty eight compounds, respectively. 1,8-Cineole (58.5% and 58.0%), α-pinene (22.7% and 24.1%), and (E)-β-terpineol (6.4% and 1.8%), were the major constituents. The isolated essential oils could be of use for the future development of antimicrobial agents.