gebhart/patrepeval huggingface dataset:
Computational dissection of tissue contamination for identification of colon cancer‐specific expression profiles (2003)

Microarray profiles of bulk tumor tissues reflect gene expression corresponding to malignant cells as well as to many different types of contaminating normal cells. In this report, we assess the feasibility of querying baseline multitissue transcriptome databases to dissect disease-specific genes. Using colon cancer as a model tumor, we show that the application of Boolean operators (AND, OR, BUTNOT) for database searches leads to genes with expression patterns of interest. The BUTNOT operator for example allows the assignment of "expression signatures" to normal tissue specimens. These expression signatures were then used to computationally identify contaminating cells within conventionally dissected tissue specimens. The combination of several logic operators together with an expression database based on multiple human tissue specimens can resolve the problem of tissue contamination, revealing novel cancer-specific gene expression. Several markers, previously not known to be colon cancer associated, are provided.
Discriminative imaging of maternal and fetal blood flow within the placenta using ultrafast ultrasound (2015)

Being able to map accurately placental blood flow in clinics could have major implications in the diagnosis and follow-up of pregnancy complications such as intrauterine growth restriction (IUGR). Moreover, the impact of such an imaging modality for a better diagnosis of placental dysfunction would require to solve the unsolved problem of discriminating the strongly intricated maternal and fetal vascular networks. However, no current imaging modality allows both to achieve sufficient sensitivity and selectivity to tell these entangled flows apart. Although ultrasound imaging would be the clinical modality of choice for such a problem, conventional Doppler echography both lacks of sensibility to detect and map the placenta microvascularization and a concept to discriminate both entangled flows. In this work, we propose to use an ultrafast Doppler imaging approach both to map with an enhanced sensitivity the small vessels of the placenta (~100 μm) and to assess the variation of the Doppler frequency simultaneously in all pixels of the image within a cardiac cycle. This approach is evaluated in vivo in the placenta of pregnant rabbits: By studying the local flow pulsatility pixel per pixel, it becomes possible to separate maternal and fetal blood in 2D from their pulsatile behavior. Significance Statement: The in vivo ability to image and discriminate maternal and fetal blood flow within the placenta is an unsolved problem which could improve the diagnosis of pregnancy complications such as intrauterine growth restriction or preeclampsia. To date, no imaging modality has both sufficient sensitivity and selectivity to discriminate these intimately entangled flows. We demonstrate that Ultrafast Doppler ultrasound method with a frame rate 100x faster than conventional imaging solves this issue. It permits the mapping of small vessels of the placenta (~100 μm) in 2D with an enhanced sensitivity. By assessing pixel-per-pixel pulsatility within single cardiac cycles, it achieves maternal and fetal blood flow discrimination.
Path Loss Modeling and Ray-Tracing Verification for 5/31/90 GHz Indoor Channels (2019)

Millimeter-wave links, which will be applied in 5G wireless communication, can suffer severe attenuation and multipath fading in indoor channels. Accurate indoor channel modeling for path loss is hence important. In this paper we address this for frequencies of 5, 31 and 90 GHz. An indoor environment is modeled and simulated via the X3D ray-tracing method in Wireless Insite® software, and results are post-processed in MATLAB. Measurements at each frequency were also made in the indoor environments for link distances up to 50 m. Two types of widely-used log-distance path loss models are used for comparing results: the close-in (CI) free-space reference model and the floating intercept (FI) model. Path loss simulation results are compared with measurement for different frequencies, antennas, and channel conditions. Our results show that CI model slopes between ray-tracing and measurements differ by less than 0.3, and model standard deviations differ by less than 2 dB for all frequencies for the line of sight (LOS) case. For a non-light-of-sight (NLOS) channel, differences are less than 0.6 for slope and 5 dB for standard deviations, illustrating the utility of ray-tracing for these frequencies and settings.
Designing for mobile experience beyond the native ad click: Exploring landing page presentation style and media usage (2018)

Many free mobile applications are supported by advertising. Ads can greatly affect user perceptions and behavior. In mobile apps, ads often follow a “native” format: they are designed to conform in both format and style to the actual content and context of the application. Clicking on the ad leads users to a second destination, outside of the hosting app, where the unified experience provided by native ads within the app is not necessarily reflected by the landing page the user arrives at. Little is known about whether and how this type of mobile ads is impacting user experience. In this paper, we use both quantitative and qualitative methods to study the impact of two design decisions for the landing page of a native ad on the user experience: (i) native ad style (following the style of the application) versus a non‐native ad style; and (ii) pages with multimedia versus static pages. We found considerable variability in terms of user experience with mobile ad landing pages when varying presentation style and multimedia usage, especially interaction between presence of video and ad style (native or non‐native). We also discuss insights and recommendations for improving the user experience with mobile native ads.
GaPt Supported Catalytically Active Liquid Metal Solution Catalysis for Propane Dehydrogenation–Support Influence and Coking Studies (2021)

Supported catalytically active liquid metal solutions (SCALMS) of Pt in Ga (2 at.-% Pt) were studied in the temperature range of 500 to 600 °C for propane dehydrogenation. A facile synthesis procedure using ultrasonication was implemented and compared to a previously reported organo-chemical route for gallium deposition. The procedure was applied to synthesize GaPt-SCALMS catalyst on silica (SiO<sub>2</sub>), alumina (Al<sub>2</sub>O<sub>3</sub>), and silicon carbide (SiC) to investigate the effect of the support material on the catalytic performance. The SiC-based SCALMS catalyst showed the highest activity, while SiO<sub>2</sub>-based SCALMS showed the highest stability and lowest cracking tendency at higher temperatures. The selectivity toward propene for the SiO<sub>2</sub>-based catalyst remained above 93% at 600 °C. The catalysts were analyzed for coke content after use by temperature-programmed oxidation (TPO) and Raman spectroscopy. While the SiC- and SiO<sub>2</sub>-supported SCALMS systems showed hardly any coke formation, the Al<sub>2</sub>O<sub>3</sub>-supported systems suffered from pronounced coking. SEM-EDX analyses of the catalysts before and after reaction indicated that no perceivable morphological changes occur during reaction. The SCALMS catalysts under investigation are compared with supported Pt and supported GaPt solid-phase catalyst, and possible deactivation pathways are discussed.
Fractal-Shaped Koch-Ring Microstrip Patch (2021)

Design of small antennas that can be integrated with the circuitry inside handheld electronic devices is an emerging research topic in the field of mobile communication. Use of circular-shaped rings is a viable solution proposed to design miniature antennas. In this paper, a novel shape is proposed for printed antennas by incorporating the Koch fractal with circular rings. The proposed Fractal-Shaped Koch-ring antennas exhibit miniature properties. The miniaturization factors of the circular ring microstrip patch antenna (MPA) and Koch-ring MPAs of first and second iterations were analyzed and their characteristics were compared in terms of the resonant-frequency at the fundamental mode, input impedance at the resonance frequency, bandwidth, radiation efficiency and the radiation pattern. Numerical and experimental results show that a fractal-shaped Koch-ring MPA resonates at a lower frequency than classical circular rings. Based on these findings, a stacked MPA with Koch-rings was designed to make the antenna miniature with high efficiency and a high directivity along the broadside radiation.
Surface modification strategy for fluorescence solvatochromism of carbon dots prepared from p-phenylenediamine (2020)

Surface modification of <italic>p</italic>-phenylenediamine-derived carbon dots with decanoic acid and perfluorodecanoic acid successfully modulated fluorescence solvatochromism.
Surface Intiated Atom Transfer Radical Polymerizations from Indium Tin Oxide Electrodes: Electrochemistry of Polymer Brushes (2012)

We discuss recent efforts on the modification of indium tin oxide electrodes via surface initiated atom transfer radical polymerization (SI-ATRP). In particular, we summarize our recent work on the development of model electrochemical thin films based on ferrocene functional polymethacrylate and block copolymer brushes and the use of electrochemical methods to confirm controlled brush growth.
The prevalence of hepatitis B infection amongst urban and rural populations in Western Samoa (1981)

A group of 240 urban and 200 rural dwellers in Western Samoa over the age of 20 years was studied for serological evidence of current or past infection with hepatitis B virus (HBV). Overall, 5.5% of subjects were found to be currently infected with HBV and a further 74.5% showed detectable levels of antibody. Antibody to the hepatitis B core antigen was found to be a better marker of past infection than antibody to the surface antigen of the virus. Both the infection rate and carrier rate were higher in males than females and subjects living in rural areas were more likely to be infected than those living in urban areas.
The European epidemic: Pain prevalence and socioeconomic inequalities in pain across 19 European countries (2019)

This is a pan European study that has explored socioeconomic inequalities in pain. Across Europe, pain is more prevalent in people of lower socioeconomic position; these pain inequalities were most significant for hand/arm pain, and least significant for back/neck pain.
A distributed fiber optic sensor based on cladding fluorescence (1990)

The fiber for the sensor is formed by cladding fused silica during drawing with polydimethyl siloxane into which an organic fluorescent dye, 9, 10-diphenylanthracene, has been dissolved. Upon side illumination at a wavelength within the excitation range of the dye, the cladding fluoresces; some of this fluorescence is coupled into guided modes in the fiber core through the evanescent fields of these modes. In the presence of oxygen, fluorescent emission by the dye is diminished. For the sensor described, the rubbery liquidlike nature of the polydimethyl siloxane cladding allows rapid diffusion of gases, and the intensity of the guided fluorescence is observed to drop by 30% in less than 5 s when the ambient atmosphere changes from pure nitrogen to pure oxygen. The advantages of this sensing technique, and some of the possibilities for new sensors based on this principle, are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Direct Electron Transfer of Enzymes Facilitated by Cytochromes (2019)

Abstract Invited for this month's cover picture is Su Ma and Roland Ludwig from BOKU—University of Natural Resources and Life Sciences, Vienna (Austria). The cover picture schematically shows electron‐transfer routes of five different types of redox centers found in multi‐cofactor oxidoreductases towards a cytochrome domain, which is capable of direct electron transfer. Read the full text of the Review at 10.1002/celc.201801256 .
Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL (2021)

IDH1 and IDH2 mutations (IDH1/2<sup>Mut</sup>) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2<sup>Mut</sup> inhibitors. In T-cell acute lymphoblastic leukemia (T-ALL), their incidence and prognostic implications remain poorly reported. Our targeted next-generation sequencing approach allowed comprehensive assessment of genotype across the entire IDH1 and IDH2 locus in 1085 consecutive unselected and newly diagnosed patients with T-ALL and identified 4% of, virtually exclusive (47 of 49 patients), IDH1/2<sup>Mut</sup>. Mutational patterns of IDH1/2<sup>Mut</sup> in T-ALL present some specific features compared to AML. Whereas IDH2<sup>R140Q</sup> mutation was frequent in T-ALL (25 of 51 mutations), the IDH2<sup>R172</sup> AML hotspot was absent. IDH2 mutations were associated with older age, an immature phenotype, more frequent RAS gain-of-function mutations and epigenetic regulator loss-of-function alterations (DNMT3A and TET2). IDH2 mutations, contrary to IDH1 mutations, appeared to be an independent prognostic factor in multivariate analysis with the NOTCH1/FBXW7/RAS/PTEN classifier. IDH2<sup>Mut</sup> were significantly associated with a high cumulative incidence of relapse and very dismal outcome, suggesting that IDH2-mutated T-ALL cases should be identified at diagnosis in order to benefit from therapeutic intensification and/or specific IDH2 inhibitors.
Nanoimprinted, Submicrometric, MOF‐Based 2D Photonic Structures: Toward Easy Selective Vapors Sensing by a Smartphone Camera (2015)

In this work, a soft‐lithographic approach to fabricate submicrometer metal organic framework (MOF)‐based 2D photonic structures is described. Nanometric zeolitic imidazole framework material ZIF‐8 (zinc) is chosen as the sensible MOF material because of its chemical stability and its vapor selective adsorption properties. Two different systems are fabricated: nanopatterned colloidal ZIF‐8 homo‐ and ZIF‐8/TiO 2 heterostructures. Several features (stripes, squares, etc.) with dimensions of 200 nm are replicated on different substrates such as silicon, flexible plastics, and even aluminum cans, over relatively large surfaces (up to 1 cm 2 ). In addition, the use of these photonic MOF‐heterostructures as very low‐cost sensing platforms compatible with smartphone technology is demonstrated. This method relies on the evaluation of the change in diffraction efficiency of the photonic MOF‐patterns, induced by the MOF refractive index variation, which is simply detected by a charge coupled device (CCD) camera, as those integrated in smartphones, without need for complex optical instrumentations for transduction data processing. Performances of the sensors are first evaluated using isopropyl alcohol adsorption/desorption cycling as a model case. In addition, a “real” environmental issue is tackled. Selective detection of styrene in presence of interfering water is demonstrated at concentrations below the human permissible exposure limit. In situ ellispometric analyses are also carried out in order to confirm the sensor performances and to propose a mechanism for styrene uptake into the nanoMOFs.
53.4: Development of 31‐Inch Full‐HD AMOLED TV Using LTPS‐TFT and RGB FMM (2009)

Abstract In this paper, we describe the technologies for implementation of the world's largest Active Matrix Organic Light‐Emitting Diode (AMOLED) TV. Low Temperature Poly‐Silicon (LTPS) method is applied to integrate driver and pixel circuit in panel. Also, we used Fine Metal Mask (FMM) for color patterned R,G,B pixels. for achieving better color gamut, we applied bottom‐emission micro‐cavity structure. As a result, we have fabricated 31‐inch Full‐HD(1920×l080) AMOLED display. The power consumption is less than 40W, which it displays motion picture. We achieved excellent performance like color gamut over 100%, contrast ratio over 1,000,000:1, life time over 35,000hrs, 200cd/m 2 white brightness (peak brightness is 550 cd/m 2 ). We now remarkably achieved a slim TV set under 1cm thickness. The module thickness including electronic devices is only 4.3mm with aluminum frame.
Isomorphous pharmaceutical salts of lamotrigine with counterion dependence on water solubility (2008)

The process of molecular recognition in inclusion compounds is governed by the intermolecular interactions which occur between the various host and guest molecules making up the resultant crystalline assembly. We have studied the diol host, 2,2'-bis (hydroxydiphenylmethyl-1,1'-binaphthyl(H), which crystallised in three different polymorphic structures and formed a series of inclusion compounds with pyridine(P), morpholine(M) and benzene(B). Different stoichiometries were obtained by manipulating the proportions of the guests and the crystallisation temperatures. Four of these inclusion compounds, H.3P, H.2P.M, H.2P.B and H.P.M.B, are isomorphous and the guests are located at fixed sites in the crystal structure. Their thermal analysis results were explained in terms of the hostguest interactions. The three polymorphs of the host compound show strong structural similarities as depicted by their Hirshfeld surface fingerprint plots, which exhibit dominant HH interactions. The conformation of the host molecule remains essentially constant, and is governed by an intramolecular O-HO hydrogen bond in the polymorphs of the apohost and in all the nine inclusion compounds analysed.
Ultrasound molecular imaging with modulated Acoustic Radiation Force-based beam sequence in mouse abdominal aorta: A feasibility study (2015)

Ultrasound-based molecular imaging has been implemented in pre-clinical studies of cancer and cardiovascular diseases. Unfortunately, existing methods face substantial challenges in large blood vessel environments. We hypothesized that a clinically translatable method, the modulated Acoustic Radiation Force (ARF)-based imaging, is capable of rapid detection of inflammation in the abdominal aorta of a murine model. Mice stimulated with tumor necrosis factor (TNF)-α were used as an inflammation model (M <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Inflammation</inf> ). Age-matched normal mice were used as controls (M <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Normal</inf> ). P-selectin-targeted (MB <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P-selectin</inf> ), and isotype control (MB <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Control</inf> ) microbubbles were synthesized by conjugating anti-P-selectin, and isotype control antibodies to the shell of microbubbles, respectively. The abdominal aorta of mice were imaged for 180 s during a constant infusion of microbubbles. The parameter produced from the new imaging sequence, residual-to-saturation ratio (RSR), was used to assess P-selectin expression. For the inflammation model, RSR of the M <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Inflammation</inf> + MB <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P-selectin</inf> group was 40.9%, significantly higher (p < 0.0005) than other groups. Feasibility was demonstrated to achieve rapid and statistically significant assessment of P-selectin in a mouse abdominal aorta for the first time. The proposed technique closes the gap toward rapid targeted molecular imaging in large blood vessels, and thus has the potential for early diagnosis and treatment selection of atherosclerosis via ultrasound molecular imaging.
Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains (2012)

The BXD reference panel allowed us to establish genetic regulation and characterize biological function of specific miRNAs. QTL analysis enabled detection of genetic loci that regulate the expression of these miRNAs. eQTLs that regulate miRNA abundance are a new mechanism by which genetic variation influences brain and behaviour. Analysis of one of these QTLs revealed a gene, Tnik, which may regulate the expression of a miRNA, a molecular pathway and a behavioural phenotype. Evidence of genetic covariation of miR-212 abundance and cocaine related behaviours is strongly supported by previous functional studies, demonstrating the value of this approach for discovery of new functional roles and downstream processes regulated by miRNA.
ChemInform Abstract: Simple Methods for the Synthesis of Cryptands and Supercryptands (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
OFF-Set: One-pass Factorization of Feature Sets for Online\n Recommendation in Persistent Cold Start Settings (2013)

One of the most challenging recommendation tasks is recommending to a new,\npreviously unseen user. This is known as the 'user cold start' problem.\nAssuming certain features or attributes of users are known, one approach for\nhandling new users is to initially model them based on their features.\n Motivated by an ad targeting application, this paper describes an extreme\nonline recommendation setting where the cold start problem is perpetual. Every\nuser is encountered by the system just once, receives a recommendation, and\neither consumes or ignores it, registering a binary reward.\n We introduce One-pass Factorization of Feature Sets, OFF-Set, a novel\nrecommendation algorithm based on Latent Factor analysis, which models users by\nmapping their features to a latent space. Furthermore, OFF-Set is able to model\nnon-linear interactions between pairs of features. OFF-Set is designed for\npurely online recommendation, performing lightweight updates of its model per\neach recommendation-reward observation. We evaluate OFF-Set against several\nstate of the art baselines, and demonstrate its superiority on real\nad-targeting data.\n
Video 4 from <i>In Vivo</i> Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing (2023)

&lt;p&gt;&lt;i&gt;Ex vivo&lt;/i&gt; analysis of the CEA TCB (magenta) mediated cross-linking of CFSE labeled T-cells (green) to tumor cells. 3D reconstructions of confocal z-stacks acquired on tumor sections obtained from huPBMC (CFSE labeled T-cells)/LS174T RFP co-grafts, 24 h after intravenous A647 labeled CEA TCB injections are shown. Bar, 10 ÃŽÂ¼m. Cell nuclei (DAPI) are shown in blue.&lt;/p&gt;