gebhart/patrepeval huggingface dataset:
Anti-miR-135b in colon cancer treatment: Results from a preclinical study. (2012)

457 Background: MicroRNAs (miRs) are small non coding RNAs involved in cell homeostasis. miRs are deregulated in colorectal cancer (CRC). Our study aimed at identifying miRs with a driver role in carcinogenesis altered by similar mechanisms in both human and mouse CRC. Goal of the study was to use CRC mouse models for the pre-clinical development of anti-miRs as therapeutic drugs. Methods: Azoximetane (AOM)/Dextran-Sulfate (DSS) treated mice or CDX2-CRE/APC -/- mice were used to study inflammation-associated and sporadic APC-related CRC. Human Inflammatory Bowel Disease associated (n=30), and sporadic (n=90) CRC with their matched normal tissues were collected according to Good Clinical Practice recommendation and subjected to RNA extraction using Trizol. miR and gene expression profiling was assessed by nCounter technology (Nanostring Seattle). Anti-miR-135b and scrambled probes for in vivo studies were synthesized by Girindus. Results: miRs profiling from AOM/DSS and CDX2-CRE/APC -/- CRC. revealed that miR-135b is one of the most up-regulated miRs in both models. In humans miR-135b over-expression was found in both IBD and sporadic CRC and was associated with reduced Progression Free Survival and Overall Survival in CRC patients. Molecular studies in Mouse Embryo Fibroblast and human CRC cell lines highlighted the role of two major pathways in the upstream activation of miR-135b: APC-β-Catenin and SRC-PI3K. MiR-135b up-regulation resulted in reduced apoptosis and increased invasion and metastasis due to the down-regulation of TGFRB2, DAPK1, APC and HIF1AN. Silencing of miR-135b in vivo reduced tumor multiplicity and tumor load in the AOM/DSS CRC model. Mice treated with anti-miR-135b showed well differentiated tumors and microacinar pattern while tumors in the control groups showed low differentiation and adenomatous pattern. Conclusions: Our data suggest that miR-135b is a key molecule whose activation is downstream of oncogenes and oncosuppressor genes frequently altered in CRC. Our study defines specific pathways that converge on the activation of the same microrna. The “in vivo” silencing of miR-135 shows preclinical efficacy with low toxicity and represents the first in vivo study for the use of antimiRs in CRC treatment.
Decomposition of Aminotetrazole Based Energetic Materials under High Heating Rate Conditions (2012)

A T-jump/time-of-flight mass spectrometer (T-Jump/TOFMS) is used to probe the decomposition of several aminotetrazole containing energetic materials under very high heating rates of 10(5)-10(6) K/s. The materials investigated are 5-amino-1-methyl-1H-tetrazolium dinitramide (MeHAT_DN), 1,5-diamino-4-methyl-1H-tetrazolium dinitramide (MeDAT_DN), 1,5-diamino-1H-tetrazolium nitrate (DAT_N), 1,5-diamino-4-methyl-1H-tetrazolium azide (MeDAT_N3), and 5-aminotetrazolium dinitramide (HAT_DN). Subtle differences between materials in functional group placement and anion composition allow for further understanding of the decomposition pathway of the tetrazole structure and various anions. Two decomposition pathways for the tetrazole ring are observed, which result in the primary formation of HN(3) or N(2). The N(2) formation pathway occurs when functional groups are placed symmetrically around the tetrazole ring, whereas asymmetric placement results in HN(3) production. The differing anion compositions also show effects on thermal stability of the salts, as is demonstrated by a lower decomposition temperature for the azide containing salt compared to the similar dinitramide containing material. For the decomposition of the dinitramide molecule, high temperature (N(2)O forming) and low temperature (NO(2) forming) decomposition pathways are observed, as has been previously suggested.
Ferroelectric Polymer Nanofibers Reminiscent of Morphotropic Phase Boundary Behavior for Improved Piezoelectric Energy Harvesting (2022)

Ferroelectric and piezoelectric polymers have attracted great attention from many research and engineering fields due to its mechanical robustness and flexibility as well as cost-effectiveness and easy processibility. Nevertheless, the electrical performance of piezoelectric polymers is very hard to reach that of piezoelectric ceramics basically and physically, even in the case of the representative ferroelectric polymer, poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)). Very recently, the concept for the morphotropic phase boundary (MPB), which has been exclusive in the field of high-performance piezoelectric ceramics, has been surprisingly confirmed in P(VDF-TrFE) piezoelectric copolymers by the groups. This study demonstrates the exceptional behaviors reminiscent of MPB and relaxor ferroelectrics in the feature of widely utilized electrospun P(VDF-TrFE) nanofibers. Consequently, an energy harvesting device that exceeds the performance limitation of the existing P(VDF-TrFE) materials is developed. Even the unpoled MPB-based P(VDF-TrFE) nanofibers show higher output than the electrically poled normal P(VDF-TrFE) nanofibers. This study is the first step toward the manufacture of a new generation of piezoelectric polymers with practical applications.
Analysis of the linear methods for determining copolymerization reactivity ratios. IV. A comprehensive and critical reexamination of carbocationic copolymerization data (1977)

Abstract Increased insight into the mechanism of carbocationic copolymerization has been achieved by classifying and reviewing in detail 334 monomer pairs in terms of the extended Kelen‐Tüdös method. The reactivity ratios ( r values) of essentially all published olefin–olefin, olefin–vinyl ether, vinyl ether‐vinyl ether, and some miscellaneous systems have been reexamined and classified. Of the systems reviewed, only 121 (36.2%) contained sufficiently detailed information for comprehensive reevaluation and classification. Of these, only 49 (14.7%) were found to contain sufficiently accurate and reliable data to satisfy acceptance in class I, i.e., systems which are adequately described by the conventional copolymer composition equation, while 40 (12%) were accepted only in class I(!), i.e., systems for which the available data are somewhat less reliable than for class I and some caution is in order when employing r values for quantitative purposes. Six (1.8%) monomer pairs were judged to belong to class II, i.e., systems for which the approximations implicit in the conventional copolymer composition equation do not hold and published r values are probably erroneous and misleading. Finally, 26 (7.8%) monomer pairs were placed in class III, i.e., systems that exhibit unacceptable data scatter in the η versus ξ plot and published r values are meaningless. In some instances, even the existence of true copolymers is questioned.
Doped colorimetric assay liposomes (2023)

The present invention provides compositions comprising colorimetric assay liposomes. The present invention also provides methods for producing colorimetric liposomes and calorimetric liposome assay systems. In preferred embodiments, these calorimetric liposome systems provide high levels of sensitivity through the use of dopant molecules. As these dopants allow the controlled destabilization of the liposome structure, upon exposure of the doped liposomes to analyte(s) of interest, the indicator color change is facilitated and more easily recognized.
AXIAL DISPERSION MODELS FOR STEADY-STATE, LAMINAR, OPEN-TUBE SYSTEMS (1978)

Abstract Mass transfer to the wall and a homogeneous first-order chemical reaction are considered separately for laminar Axial dispersion coefficients for steady-state systems computed from exact solutions for the concentration profiles are shown to be strong functions of axial position. For the homogeneous first-order reaction case, the axial dispersion coefficient is a function of the reaction rate constant.
Supplementary Methods and Figure Legend from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer (2023)

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Transient mid-IR study of electron dynamics in TiO2 conduction band (vol 138, pg 1966, 2013) (2013)

Transient mid-IR study of electron dynamics in TiO2 conduction band (vol 138, pg 1966, 2013)
Genome-wide Expression Profiling, In Vivo DNA Binding Analysis, and Probabilistic Motif Prediction Reveal Novel Abf1 Target Genes during Fermentation, Respiration, and Sporulation in Yeast (2008)

The autonomously replicating sequence binding factor 1 (Abf1) was initially identified as an essential DNA replication factor and later shown to be a component of the regulatory network controlling mitotic and meiotic cell cycle progression in budding yeast. The protein is thought to exert its functions via specific interaction with its target site as part of distinct protein complexes, but its roles during mitotic growth and meiotic development are only partially understood. Here, we report a comprehensive approach aiming at the identification of direct Abf1-target genes expressed during fermentation, respiration, and sporulation. Computational prediction of the protein's target sites was integrated with a genome-wide DNA binding assay in growing and sporulating cells. The resulting data were combined with the output of expression profiling studies using wild-type versus temperature-sensitive alleles. This work identified 434 protein-coding loci as being transcriptionally dependent on Abf1. More than 60% of their putative promoter regions contained a computationally predicted Abf1 binding site and/or were bound by Abf1 in vivo, identifying them as direct targets. The present study revealed numerous loci previously unknown to be under Abf1 control, and it yielded evidence for the protein's variable DNA binding pattern during mitotic growth and meiotic development.
Supplementary Methods from Construction and Characterization of Novel, Recombinant Immunotoxins Targeting the <i>Her2/neu</i> Oncogene Product: <i>In vitro</i> and <i>In vivo</i> Studies (2023)

Supplementary Methods from Construction and Characterization of Novel, Recombinant Immunotoxins Targeting the &lt;i&gt;Her2/neu&lt;/i&gt; Oncogene Product: &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; Studies
Pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxides. Synthesis of SO2 analogues of folic acid antagonists (1991)

Abstract The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxide system incorporating the glutamic acid side chain at the 7‐position is described. No significant DHFR inhibition of cytotoxic activity has been found with these compounds.
High-mobility bottom-contact n-channel organic transistors and their use in complementary ring oscillators (2006)

The electrical characteristics of bottom-contact organic field-effect transistors fabricated with the air-stable n-type semiconductor N,N′-bis(n-octyl)-dicyanoperylene-3,4:9,10-bis(dicarboximide) (PDI-8CN2) are described. The mobility, threshold voltage, subthreshold swing, and Ion∕Ioff ratio(VDS=40V, VG=0∼40V) are 0.14cm2∕Vs, 1.6V, 2.0V/decade, and 1.2×103, respectively. The effect of electrode/dielectric surface treatment on these devices is also examined, with a combination of 1-octadecanethiol and hexamethyldisilazane. Organic complementary five-stage ring oscillators were fabricated using pentacene and PDI-8CN2, and operated at an oscillation frequency of 34kHz and a propagation delay per stage of 3μs.
Artificial Weathering and Recycling Effect on Intumescent Polypropylenebased Blends (2004)

The first part of this work deals with the effect of ageing (artificial weathering) on an intumescent flame-retarded ammonium polyphosphate (APP)/polyamide-6 (PA-6)/polypropylene (PP) blend. The study of the fire properties using the cone calorimeter shows a decrease in the performance caused by the artificial weathering. The chemical modifications of the blends after ageing are investigated by solid state 31 P NMR and SEM. It is shown that APP is degraded into ortho-, pyrophosphate and short chain polyphosphates. These modifications lead to the loss of the ammonium contents which could explain the decrease of fire performance. Moreover, some morphological changes appear which may lead to the change of fire and mechanical properties. A classical solution for re-using the material is the recycling. In the second part of this study, we examine the effect of recycling simulated by a multi-extrusion process. This treatment induces modifications which are different from those resulting from the effect of ageing. So, morphological and chemical changes induced by recycling are compared to the effects of ageing. It is shown that after recycling APP is also degraded in the same way as after ageing. In addition to the degradation of APP, a decrease in phosphorous concentration is observed which is attributed to the migration of phosphate species.
Infinitely many kinds of quantum channels (2008)

We define the ability of a quantum channel to simulate another by means of suitable encoding and decoding operations. While classical channels have only two equivalence classes under simulation (channels with non-vanishing capacity and those with vanishing capacity), we show that there are an uncountable infinity of different equivalence classes of quantum channels using the example of the quantum erasure channel. Our results also imply a kind of 'Matthew principle' for error correction on certain channels.
Optimal preview control for a linear continuous-time stochastic control system in finite-time horizon (2016)

This paper discusses the design of the optimal preview controller for a linear continuous-time stochastic control system in finite-time horizon, using the method of augmented error system. First, an assistant system is introduced for state shifting. Then, in order to overcome the difficulty of the state equation of the stochastic control system being unable to be differentiated because of Brownian motion, the integrator is introduced. Thus, the augmented error system which contains the integrator vector, control input, reference signal, error vector and state of the system is reconstructed. This leads to the tracking problem of the optimal preview control of the linear stochastic control system being transformed into the optimal output tracking problem of the augmented error system. With the method of dynamic programming in the theory of stochastic control, the optimal controller with previewable signals of the augmented error system being equal to the controller of the original system is obtained. Finally, numerical simulations show the effectiveness of the controller.
Supplementary Data 2 from Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression (2023)

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Design of a Bio-Inspired Spherical Four-Bar Mechanism for Flapping-Wing Micro Air-Vehicle Applications (2010)

The design of flapping-wing micro air-vehicles presents many engineering challenges. As observed by biologists, insects and birds exhibit complex three-dimensional wing motions. It is believed that these unique patterns of wing motion create favorable aerodynamic forces that enable these species to fly forward, hover, and execute complex motions. From the perspective of micro air-vehicle applications, extremely light-weight designs that accomplish these motions of the wing, using just a single or a few actuators, are preferable. This paper presents a method to design a spherical four-bar flapping mechanism that approximates a given spatial flapping motion of a wing, considered to have favorable aerodynamics. A spherical flapping mechanism was then constructed and its aerodynamic performance was compared to the original spatially moving wing using an instrumented robotic flapper with force sensors.
A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97. (1989)

Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
Prototype-based minimum error classifier for handwritten digits recognition (2004)

The paper describes an application of the prototype-based minimum error classifier (PBMEC) to the offline recognition of handwritten digits. The PBMEC uses a set of prototypes to represent each digit along with an L/sub /spl nu//-norm of distances as the decoding scheme. Optimization of the system is based on the minimum classification error (MCE) criterion. We introduce a new clustering criterion adapted to the PBMEC structure that minimizes an L/sub /spl nu//-norm-based distortion measure. The new clustering algorithm can generate a smaller number of prototypes than the standard k-means with no loss in accuracy. It is also shown that the PBMEC trained with MCE can achieve over 42% improvement from the baseline k-means process and requires only 28 Kb storage to match the performance of a 1.46 Mb sized k-NN classifier.
Hyperimmune Bovine Colostrum as a Novel Therapy to Combat Clostridium difficile Infection (2014)

HBC provides an oral, cost-effective, and safe alternative to antibiotic therapy for CDI. By preserving intestinal microbiota, HBC may be more efficacious than antibiotics. Additional studies are warranted to establish HBC as a viable immunotherapeutic agent for human use against CDI.
The CsLnMSe3 Semiconductors (Ln = Rare-Earth Element, Y; M = Zn, Cd, Hg) (2003)

CsLnCdSe3 (Ln = Ce, Pr, Sm, Gd, Tb, Dy, Y) and CsLnHgSe3 (Ln = La, Ce, Pr, Nd, Sm, Gd, Y) have been synthesized at 1123 K. These isostructural materials crystallize in the layered KZrCuS3 structure type in the orthorhombic space group Cmcm and are group X extensions of the previously characterized Zn compounds. The structure is composed of two-dimensional [LnMSe3] layers that stack perpendicular to [010] and are separated by layers of face- and edge-sharing CsSe8 bicapped trigonal prisms. Because there are no Se−Se bonds in the structure of CsLnMSe3 (M = Zn, Cd, Hg), the formal oxidation states of Cs/Ln/M/Se are 1+/3+/2+/2−. CsSmHgSe3 does not adhere to the Curie−Weiss law, whereas CsCeHgSe3 and CsGdHgSe3 are Curie−Weiss paramagnets with μeff values of 2.77 and 7.90 μB, corresponding well with the theoretical values of 2.54 and 7.94 μB for Ce3+ and Gd3+, respectively. Single-crystal optical absorption measurements were performed with polarized light perpendicular to the (010) and (001) crystal faces of these materials. The band gaps of the (010) crystal faces range from 1.94 eV (CsCeHgSe3) to 2.58 eV (CsYCdSe3) whereas those of the (001) crystal faces span the range 2.37 eV (CsSmHgSe3) to 2.54 eV (CsYCdSe3 and CsYHgSe3). The largest band gap variation between crystal faces is 0.06 eV for CsYCdSe3. Theoretical calculations for CsYMSe3 indicate that these materials are direct band gap semiconductors whose colors and optical band gaps are dependent upon the orbitals of Y, M, and Se.
In vivo assessment of the pulmonary micro-circulation using fibered confocal fluorescence microscopy in a murine model of emphysema (2009)

International audience
Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma (2020)

Melanoma is the most severe type of skin cancer. Its unique and heterogeneous metabolism, relying on both glycolysis and oxidative phosphorylation, allows it to adapt to disparate conditions. Mitochondrial function is strictly interconnected with mitochondrial dynamics and both are fundamental in tumour progression and metastasis. The malignant phenotype of melanoma is also regulated by the expression levels of the enzyme acid sphingomyelinase (A-SMase). By modulating at transcriptional level A-SMase in the melanoma cell line B16-F1 cells, we assessed the effect of enzyme downregulation on mitochondrial dynamics and function. Our results demonstrate that A-SMase influences mitochondrial morphology by affecting the expression of mitofusin 1 and OPA1. The enhanced expression of the two mitochondrial fusion proteins, observed when A-SMase is expressed at low levels, correlates with the increase of mitochondrial function via the stimulation of the genes PGC-1alpha and TFAM, two genes that preside over mitochondrial biogenesis. Thus, the reduction of A-SMase expression, observed in malignant melanomas, may determine their metastatic behaviour through the stimulation of mitochondrial fusion, activity and biogenesis, conferring a metabolic advantage to melanoma cells.
Fullerene Formation via Pyrolysis of Ragged Single-wall Carbon Nanotubes (2002)

A new path of fullerene formation via pyrolysis of ragged single-wall carbon nanotubes (r-SWNTs) which were treated by ultrasonication with an organic solvent followed by heating in oxygen gas is reported. Mass spectrum and high-performance liquid chromatography results indicated that C60, C70, and higher fullerenes existed in products obtained through the pyrolysis of the r-SWNTs at above 800 °C in vacuum. We suggest that the pyrolysis of r-SWNTs originates from holes and defects in the r-SWNTs.
When to Perform Fusion Short of the Pelvis in Patients with Cerebral Palsy? (2023)

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Octave-Spanning Supercontinuum Generation in a Silicon Nitride Waveguide Pumped by a Femtosecond Fiber Laser at 1.9 μm (2015)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text R. Salem, Y. Okawachi, M. Yu, M. R. E. Lamont, K. Luke, P. Fendel, M. Lipson, and A. L. Gaeta, "Octave-Spanning Supercontinuum Generation in a Silicon Nitride Waveguide Pumped by a Femtosecond Fiber Laser at 1.9 μm," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper STu1I.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Validation Study of a 3D PIC Model for a Miniature Microwave Discharge Ion Thruster (2014)

The effect of the plasma current at low powers (< 1 W) has been investigated and numerical results have been compared with experimental data to validate a three dimensional particle model for a visualized miniature microwave discharge ion thruster. The numerical model is composed of a particle-in-cell simulation with a Monte Carlo collision algorithm for the kinetics of charged particles, a finite-difference time-domain method for the electromagnetic fields of 4.2-GHz microwaves, and a finite element analysis for the magnetostatic fields of permanent magnets. The simulations with and without the feedback of the plasma current have been conducted and the differences in the distributions of plasma parameters are found to be negligible. The distribution of Xe metastable (1s5) obtained from the simulation is in a qualitative agreement with that from an experimental measurement.