gebhart/patrepeval huggingface dataset:
Nerve Sparing Laparoscopic Radical Prostatectomy (2002)

No AccessJournal of UrologyUROLOGICAL SURVEY: Video Reviews: LAPAROSCOPY1 Jan 2002Nerve Sparing Laparoscopic Radical Prostatectomy Philip M. Hanno and M.D. Ralph V. ClaymanM.D. Philip M. HannoPhilip M. Hanno More articles by this author and Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65493-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Nerve Sparing Laparoscopic Radical Prostatectomy." The Journal of Urology, 167(1), p. 440 © 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 167Issue 1January 2002Page: 440 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.MetricsAuthor Information Philip M. Hanno More articles by this author Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Design and implementation of a portable physiologic data acquisition system* (2007)

The PDAS provides a reliable tool to record physiologic signals and associated clinical events on a second-to-second basis and may serve as an important adjunctive research tool in designing and performing clinical physiologic studies in critical illness and injury.
EL INGREDIENTE EXPERIENCIA EN EL APRENDIZAJE UNIVERSITARIO (PERSPECTIVA DE UN EDUCADOR FÍSICO) (2012)

Aragon-Vargas, L.F. (2012). The Experiential Ingredient in College Learning (A Physical Educator’s Perspective). PENSAR EN MOVIMIENTO : Revista de Ciencias del Ejercicio y la Salud, 10 (1), 1-5. This editorial is an essay, reflecting on the role that experiences play in the learning process of college students. A small collection of anecdotes is used to illustrate a few basic concepts of experiential learning: the danger of incomplete learning resulting in a false sense of security; the importance of the intriguing question and how that intriguing question translates into the teaching of sports and physical education skills; the power of emotions in the learning process; the extension of experiences beyond the particular skills involved; and the need to supplement experiences with reflection, assimilation and model development, where the person with a teaching role needs to be always intentional or goaloriented.
Long‐Term Entecavir Treatment Results in Sustained Antiviral Efficacy and Prolonged Life Span in the Woodchuck Model of Chronic Hepatitis Infection (2001)

Entecavir (ETV) is a guanosine nucleoside analogue with potent antiviral efficacy in woodchucks chronically infected with woodchuck hepatitis virus. To explore the consequences of prolonged virus suppression, woodchucks received ETV orally for 8 weeks and then weekly for 12 months. Of the 6 animals withdrawn from therapy and monitored for an additional 28 months, 3 had a sustained antiviral response and had no evidence of hepatocellular carcinoma (HCC). Of the 6 animals that continued on a weekly ETV regimen for an additional 22 months, 4 exhibited serum viral DNA levels near the lower limit of detection for >2 years and had no evidence of HCC. Viral antigens and covalently closed circular DNA levels in liver samples were significantly reduced in all animals. ETV was well tolerated, and there was no evidence of resistant variants. On the basis of historical data, long-term ETV treatment appeared to significantly prolong the life of treated animals and delay the emergence of HCC.
86-OR: Association of Cognitive Function with Retinal Neural Structure and Vasculature in Type 1 Diabetes (2019)

Early cognitive decline, a dreaded complication of diabetes, is difficult and time consuming to diagnose. The Joslin Medalist Study, comprising individuals with ≥50 years of type 1 diabetes (T1D), reported that cognitive dysfunction was greater in T1D patients as compared to age-matched nondiabetic controls and was associated with proliferative diabetic retinopathy (PDR). We examined a larger Medalist sample to determine whether cognitive dysfunction is correlated with specific structural and vascular abnormalities in the retina, which embryonically is an extension of the central nervous system. Retinal imaging techniques such as optical coherence tomography (OCT) and OCT angiography (OCTA) can quantitate structural changes in individual retinal layers and the superficial and deep capillary plexus of the retinal microvasculature. We assessed Medalists (n=110) who underwent cognitive testing consisting of 5 validated measures in the following domains: executive functioning (EF), motor skills (MS), and immediate (IM), delayed (DM) and working memory (WM). Thinning of the neuroretinal ganglion cell layer (β: 0.69, P: 0.02) and inner plexiform layer (β: 0.56, P: 0.01) was associated with worse EF. PDR was associated with worse cognitive function (MS, dominant hand: OR: 1.02, P: 0.01; MS, non-dominant hand: OR: 1.01, P: 0.02; EF: OR: 0.83, P: 0.03) and decreased superficial retinal capillary plexus density (p=0.001). Decreased vessel density of the deep capillary plexus was associated with worse cognitive function including DM (β: 0.10, P: 0.01), IM (β: 0.10, P: 0.02), MS (dominant β: -0.07, P: 0.01; non-dominant β: -0.04, P: 0.03), even after adjusting for DR severity, T1D duration and visual acuity. These findings suggest that noninvasive ocular imaging techniques have potential to identify T1D individuals with early cognitive impairment, and provide insights into pathophysiological connections between cognitive function, diabetes and microvascular complications. Disclosure S.M. Paniagua: None. W. Fickweiler: None. V. Bahnam: None. K. Sampani: None. I. Wu: None. H. Shah: None. G. Musen: None. L.P. Aiello: Advisory Panel; Self; Novo Nordisk A/S. Consultant; Self; Decision Resources Group, KalVista Pharmaceuticals, Inc., Mingsight, Retinal Solutions. Stock/Shareholder; Self; KalVista Pharmaceuticals, Inc. Other Relationship; Self; Optos. J.K. Sun: Research Support; Self; Adaptive Sensory Technology, Boston Micromachines Corporation, Genentech, Inc., KalVista Pharmaceuticals, Inc., Optovue, Incorporated. Other Relationship; Self; Genentech, Inc., Novartis Pharmaceuticals Corporation, Novo Nordisk Inc. G.L. King: Research Support; Self; Sanofi. Funding National Institute of Diabetes and Digestive and Kidney Diseases (P30DK036836, UL1RR025758-03, R24283DK083957-01, DP3DK094333-01, T32DK007260); JDRF (17-2013-310); Thomas J. Beatson, Jr. Foundation Inc.
Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells (2020)

<b>Rationale:</b> Genetic association studies have identified rs2076295 in association with idiopathic pulmonary fibrosis (IPF). We hypothesized that rs2076295 is the functional variant regulating <i>DSP</i> (<i>desmoplakin</i>) expression in human bronchial epithelial cells, and <i>DSP</i> regulates extracellular matrix-related gene expression and cell migration, which is relevant to IPF development.<b>Objectives:</b> To determine whether rs2076295 regulates <i>DSP</i> expression and the function of DSP in airway epithelial cells.<b>Methods:</b> Using CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 editing (including regional deletion, indel, CRISPR interference, and single-base editing), we modified rs2076295 and measured <i>DSP</i> expression in edited 16HBE14o- and primary airway epithelial cells. Cellular integrity, migration, and genome-wide gene expression changes were examined in 16HBE14o- single colonies with <i>DSP</i> knockout. The expression of <i>DSP</i> and its relevant matrix genes was measured by quantitative PCR and also analyzed in single-cell RNA-sequencing data from control and IPF lungs.<b>Measurements and Main Results:</b><i>DSP</i> is expressed predominantly in bronchial and alveolar epithelial cells, with reduced expression in alveolar epithelial cells in IPF lungs. The deletion of the DNA region-spanning rs2076295 led to reduced expression of <i>DSP</i>, and the edited rs2076295GG 16HBE14o- line has lower expression of <i>DSP</i> than the rs2076295TT lines. Knockout of <i>DSP</i> in 16HBE14o- cells decreased transepithelial resistance but increased cell migration, with increased expression of extracellular matrix-related genes, including <i>MMP7</i> and <i>MMP9</i>. Silencing of <i>MMP7</i> and <i>MMP9</i> abolished increased migration in <i>DSP</i>-knockout cells.<b>Conclusions:</b> rs2076295 regulates <i>DSP</i> expression in human airway epithelial cells. The loss of <i>DSP</i> enhances extracellular matrix-related gene expression and promotes cell migration, which may contribute to the pathogenesis of IPF.
ChemInform Abstract: Rigid Aminoalcohol Backbone as a Highly Defined Chiral Template for the Preparation of Optically Active Tertiary α‐Hydroxyl Acids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Distributed message passing for large scale graphical models (2011)

In this paper we propose a distributed message-passing algorithm for inference in large scale graphical models. Our method can handle large problems efficiently by distributing and parallelizing the computation and memory requirements. The convergence and optimality guarantees of recently developed message-passing algorithms are preserved by introducing new types of consistency messages, sent between the distributed computers. We demonstrate the effectiveness of our approach in the task of stereo reconstruction from high-resolution imagery, and show that inference is possible with more than 200 labels in images larger than 10 MPixels.
Fast Global Optimization for Hybrid Beamforming in Limited Feedback mmWave Systems (2022)

Hybrid beamforming provides a cost effective strategy towards practical deployment of massive multiple-input multiple-output (MIMO) systems. Since the hybrid precoder-combiner evaluation requires channel state information, the computation is performed at the receiver and the evaluated precoders are communicated back to the transmitter. This transmission overhead associated with the precoder feedback can be large when the number of transmit antennas is high. In this letter, we study the optimization associated with hybrid beamforming in limited feedback systems. We propose an efficient solution for the optimization under a codebook constraint and prove that the proposed solution is globally optimal when the codebook is orthonormal. The proposed approach is also shown to provide superior performance compared to existing approaches in a limited feedback setup. Further, it exhibits a computational complexity far lower than existing alternatives, making it feasible for deployment in real, resource constrained systems.
Le français, la plus germanique des langues romanes ? (2015)

[Université de Liège - http://hdl.handle.net/2268/196275]
Effect of surface crystal-Eorder on the interior smectic-A–hexatic-Btransition (1992)

Detailed heat-capacity measurements have been carried out on free-standing liquid-crystal films of n-heptyl-4'-n-pentyloxybisphenyl-4-carboxylate to investigate the nature of transitions related to surface crystal-E order. Distinct thermal hystereses are observed. Upon heating from the temperature range exhibiting surface crystal-E order and interior hexatic order, anomalous effects on the interior hexatic-B--smectic-A transition, which strongly depend on the film thickness, are evident.
Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen (2009)

Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the present study, we find that HKH20, a peptide derived from human high molecular weight kininogen (HK), down-regulates inflammatory reactions caused by Streptococcus pyogenes in a mouse model of sepsis. HK is a component of the pro-inflammatory and pro-coagulant contact system. Activation of the contact system in the bloodstream by S pyogenes leads to massive tissue damage in the lungs of the infected mice, which eventually results in the death of the animals. HKH20 inhibits activation of the contact system and protects mice with invasive S pyogenes infection from lung damage. In combination with clindamycin treatment, the peptide also significantly prolongs the survival of infected mice.
Glycolysis, monocarboxylate transport, and purinergic signaling are key events in Eimeria bovis-induced NETosis (2022)

The protozoan parasite <i>Eimeria bovis</i> is the causative agent of bovine coccidiosis, an enteric disease of global importance that significantly affects cattle productivity. Previous studies showed that bovine NETosis-an important early host innate effector mechanism of polymorphonuclear neutrophil (PMN)-is elicited by <i>E. bovis</i> stages. So far, the metabolic requirements of <i>E. bovis</i>-triggered NET formation are unknown. We here studied early glycolytic and mitochondrial responses of PMN as well as the role of pH, distinct metabolic pathways, P2 receptor-mediated purinergic signaling, and monocarboxylate transporters 1 and 2 (MCT1, MCT2) in <i>E. bovis</i> sporozoite-induced NET formation. Seahorse-based experiments revealed a rapid induction of both neutrophil oxygen consumption rate (OCR) and early glycolytic responses, thereby reflecting immediate PMN activation and metabolic changes upon confrontation with sporozoites. The impact of these metabolic changes on NET formation was studied <i>via</i> chemical inhibition experiments targeting glycolysis and energy generation by the use of 2-fluor-2-deoxy-D-glucose (FDG), 6-diazo-5-oxo-L-norleucin (DON), sodium dichloroacetate (DCA), oxythiamine (OT), sodium oxamate (OXA), and oligomycin A (OmA) to block glycolysis, glutaminolysis, pyruvate dehydrogenase kinase, pyruvate dehydrogenase, lactate dehydrogenase, and mitochondrial ATP-synthase, respectively. Overall, sporozoite-induced NET formation was significantly diminished <i>via</i> PMN pretreatments with OmA and OXA, thereby indicating a key role of ATP- and lactate-mediated metabolic pathways. Consequently, we additionally studied the effects of extracellular pH, MCT1, MCT2, and purinergic receptor inhibitors (AR-C141900, AR-C155858, theobromine, and NF449, respectively). Pretreatment with the latter inhibitors led to blockage of sporozoite-triggered DNA release from exposed bovine PMN. This report provides first evidence on the pivotal role of carbohydrate-related metabolic pathways and purinergic receptors being involved in <i>E. bovis</i> sporozoite-induced NETosis.
Isolation and characterization of a highly specific monoclonal antibody targeting the botulinum neurotoxin type E exposed SNAP-25 neoepitope (2021)

Abstract Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. Specific detection and quantification of BoNT/E-cleaved SNAP-25 neoepitope is essential for diagnosis of BoNT/E intoxication as well as for characterization of anti-BoNT/E antibody preparations. In order to isolate highly specific monoclonal antibodies suitable for in vitro immuno-detection of the exposed neoepitope, mice and rabbits were immunized with an eight amino acid peptide composed of the C-terminus of the cleaved SNAP-25. Immunized rabbits developed a specific and robust polyclonal antibody response, whereas immunized mice mostly demonstrated a weak antibody response that could not discriminate between the two forms of SNAP-25. An immune scFv phage-display library was constructed from the immunized rabbits and a panel of antibodies was isolated. Sequence alignment of the isolated clones revealed high similarity between both heavy and light chains, with exceptionally short HCDR3 sequences. A chimeric scFv-Fc antibody was further expressed and characterized, exhibiting a selective, ultra-high affinity (pM) towards the SNAP-25 neoepitope. Moreover, this antibody enabled sensitive detection of the cleaved SNAP-25 in BoNT/E treated SiMa cells with no cross reactivity with the intact SNAP-25. This novel antibody can be further used to develop an in vitro cell-based assay to diagnose BoNT/E intoxication and to characterize antitoxin preparations, thus eliminating the use of animals in the standard mouse bioassay.
Integrating photonic crystals in thin film silicon photovoltaics (2010)

Wave-optics analysis is performed to investigate the benefits of integrating photonic crystals into micromorph cells. Specifically, we theoretically investigate two novel micromorph cells which integrate photonic crystals and compare their optical performance with that of conventional micromorph cells. In the first innovative micromorph cell configuration the intermediate reflector is a selectively transparent and conducting photonic crystal (STCPC). In the second micromorph cell its bottom &#956;c-Si:H cell is structured in the form of an inverted opal. Our results show that with the AM1.5 solar spectrum at normal incidence the current generated in a conventional micromorph cell is increased from 12.1 mA/cm2 to 13.0 mA/cm2 when the bottom &#956;c-Si:H cell is structured in the form of an inverted opal. However, the current generated in the micromorph cell can be increased to as much as 13.7 mA/cm2 when an STCPC is utilized as the intermediate reflector. Furthermore, the thickness of the &#956;c-Si:H opal must be relatively large in order to absorb a sufficient amount of the solar irradiance, which is expected to degrade the electrical performance of the device. In contrast, our results suggest that STCPC intermediate reflectors are a viable technology that could potentially enhance the performance of micromorph cells.
Thin ferroelectric Lead Lanthanum Zirconate Titanate (PLZT) films for Spatial Light Modulators on Silicon on Sapphire (1990)

This paper explores the development of a Silicon/PLZT on Sapphire Spatial Light Modulator using R-F magnetron sputtered thin film PLZT. Lead Lanthanum Zirconate Titanate (PLZT) is a transparent ferroelectric material exhibiting large quadratic electro-optic effect [1] . Sapphire forms an excellent choice as substrate to build high density Silicon-on-Sapphire CMOS circuits. By growing PLZT films on sapphire one can create Silicon-based Smart Spatial Light Modulators (S-SLMs). Fig.1 shows the configuration of such a device. The thin film PLZT transverse light modulators offer attractive features such as high speeds (due to low intrinsic capacitance) and low switching energies when used in a Fabry-Perot interferometer. In addition, since silicon device development is done prior to the deposition of PLZT films, CMOS VLSI circuits of any complexity can be achieved on the sapphire substrate in standard CMOS foundries. The most important step in the creation of such a device, is the growth of PLZT films of the right composition and crystallinity. In this paper we report the characterization of PLZT(9/65/35) films deposited on R plane (11¯02) sapphire. PLZT (9/65/35) composition was chosen for its large quadratic electro-optic coefficient. R-plane (11¯02) sapphire was chosen as substrate to provide compatibility with Silicon-on Sapphire technology.
Exploring Robustness Connection between Artificial and Natural Adversarial Examples (2022)

Although recent deep neural network algorithm has shown tremendous success in several computer vision tasks, their vulnerability against minute adversarial perturbations has raised a serious concern. In the early days of crafting these adversarial examples, artificial noises are optimized through the network and added in the images to decrease the confidence of the classifiers against the true class. However, recent efforts are showcasing the presence of natural adversarial examples which can also be effectively used to fool the deep neural networks with high confidence. In this paper, for the first time, we have raised the question that whether there is any robustness connection between artificial and natural adversarial examples. The possible robustness connection between natural and artificial adversarial examples is studied in the form that whether an adversarial example detector trained on artificial examples can detect the natural adversarial examples. We have analyzed several deep neural networks for the possible detection of artificial and natural adversarial examples in seen and unseen settings to set up a robust connection. The extensive experimental results reveal several interesting insights to defend the deep classifiers whether vulnerable against natural or artificially perturbed examples. We believe these findings can pave a way for the development of unified resiliency because defense against one attack is not sufficient for real-world use cases.
Erratum to: Nomenclature and graphic representations for chemically modified polymers (IUPAC Recommendations 2014) (2015)

International audience
Interactions between intradialytic central venous oxygen saturation, relative blood volume, and all‐cause mortality in maintenance hemodialysis patients (2023)

Concurrent combined monitoring of intradialytic ScvO<sub>2</sub> and RBV change may provide additional insights into a patient's circulatory status. Patients with low ScvO<sub>2</sub> and small changes in RBV may represent a specifically vulnerable group of patients at particularly high risk for adverse outcomes, possibly related to poor cardiac reserve and fluid overload.
General approach to error prediction in point registration (2010)

A method for the first-order analysis of the point registration problem is presented and validated. The method is a unified approach to the problem that allows for inhomogeneous and anisotropic fiducial localization error (FLE) and arbitrary weighting in the registration algorithm. Cross-covariance matrices are derived both for target registration error (TRE) and for weighted fiducial registration error (FRE). Furthermore, it is shown that for ideal weighting, in which the weighting matrix for each fiducial equals the inverse of the square root of the cross covariance of the two-space FLE for that fiducial, fluctuations of FRE and TRE are independent. These results are validated by comparison with previously published expressions for special cases and by simulation and shown to be correct. Furthermore, simulations for randomly generated fiducial positions and FLEs are presented that show that correlation is negligible (correlation coefficient &lt; 0.1) for uniform weighting (i.e., no weighting) as well. From these results we conclude that measures of the goodness of fit of the fiducials, e.g., FRE, are unreliable estimators of registration accuracy, i.e., TRE, and should be avoided.