gebhart/patrepeval huggingface dataset:
Multiplicity criteria for multireaction networks (1983)

Abstract A general method is developed for a systematic determination of criteria predicting steady‐state multiplicity in lumped‐parameter systems in which many irreversible reactions occur simultaneously. The method enables use of criteria derived for simple reaction networks to predict the behavior of more complex networks. The available multiplicity criteria for the single‐ and two‐reaction networks can always be used to write down sufficient multiplicity criteria for any multireaction system. Several examples illustrate the power of the proposed technique.
Colorectal cancer screening of the general population in East Asia (2015)

In recent years, the incidence of colorectal cancer (CRC) has been increasing, and CRC has been becoming the major cause of cancer deaths in Asian countries. Therefore, an organized screening program to reduce CRC incidence and mortality is currently implemented in each country. In the present review, we summarize the current status and future perspectives of CRC screening of the general population in East Asian and South-East Asian countries. The fecal occult blood test is widely used for CRC screening in these countries, and its effectiveness in reducing CRC incidence and mortality has been demonstrated; however, the low participation rate in CRC screening programs is a problem to be solved in every country. Improvement in the public awareness of CRC and promotion of CRC screening by physicians will help to raise the participation rate and reduce the number of deaths caused by CRC. Regarding screening colonoscopy, several studies have recently demonstrated its effectiveness in reducing CRC incidence and mortality. However, at present, CRC screening colonoscopy is not adopted as a primary population-based screening tool because of staffing constraints in relation to large population sizes, increased medical costs, and potential adverse events (e.g., perforation and drug-induced anaphylaxis). Further study is required to consider colonoscopy as CRC screening that is established in Western countries.
Validation of automated screening for referable diabetic retinopathy with the IDx‐DR device in the Hoorn Diabetes Care System (2017)

Automated grading using the IDx-DR device for RDR detection is a valid method and can be used in primary care, decreasing the demand on ophthalmologists.
Metabolic Clearance of Human Follicle-Stimulating Hormone Assessed by Radioimmunoassay, Immunoradiometric Assay, andin VitroSertoli Cell Bioassay* (1991)

We measured the equilibrium MCR of purified human FSH via continuous infusion and its half-life by bolus injection in gonadotropin-deficient men. Serum FSH concentrations were determined by RIA, immunoradiometric assay, and an in vitro FSH bioassay (rat Sertoli cell). At steady state, the MCR of FSH averaged 5.4 +/- 0.4 mL/min.m2, which was not statistically different in the three assays at the three different infusion rates. The half-life of FSH after bolus injection averaged 274 +/- 45 min (4.6 +/- 0.75 h) when analyzed as a single exponential, and 1.8 and 10 h for biexponential kinetics. The distribution volume of FSH was 3.1 L (immunoradiometric assay) and 2.1 L (bioassay). In summary, the MCR of human FSH is invariant across a range of physiological gonadotropin concentrations and quantitatively similar in three different immunological/biological assays. These results support the hypothesis that removal of circulating FSH molecules proceeds in parallel for immunoreactive and biologically active glycoprotein hormone.
ChemInform Abstract: Synthesis, DNA‐Damaging and Cytotoxic Properties of Novel Topoisomerase II‐Directed Bisantrene Analogues. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
INFLUENCE OF WATER ON CARBONATION OF &#947;-C<sub>2</sub>S AND CARBONATION BEHAVIOR OF HARDENED PASTE CONTAINING &#947;-C<sub>2</sub>S (2014)

γ-2CaO・SiO2（γ-C2S）と、γ-C2Sを混和したセメント硬化体の炭酸化挙動を比較検討した。γ-C2Sを炭酸化する際に水を添加することで、28日における反応率は4％から33％に増加し、更に継続的に水を供給することで、71％まで増加した。一方、セメント硬化体中のγ-C2Sは、水の供給を行っていないにも関わらず、継続的に炭酸化が進行し、反応率は促進91日で75％まで増加した。セメント硬化体の細孔中に存在する水や、セメント水和物が炭酸化して分解する際に放出される水によってγ-C2Sの炭酸化が効果的に進行すると考察した。γ-C2SをOPCと併用することが、γ-C2Sの炭酸化を促進する効果的な組み合わせであることが明らかになった。
Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism (2022)

Abstract SARS-CoV-2 Omicron variants have generated a world-wide health crisis due to resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of antibodies induced by vaccination. Here, we describe the SARS-CoV-2 neutralizing SP1-77 antibody that was generated from a humanized mouse model with a single human V H 1-2 and Vκ1-33-associated with immensely diverse complementarity-determining-region-3 (CDR3) sequences. SP1-77 potently and broadly neutralizes SARS-CoV-2 variants of concern and binds the SARS-CoV-2 spike protein receptor-binding-domain (RBD) via a novel-CDR3-based mode. SP1-77 does not block RBD-binding to the ACE2-receptor or endocytosis step of viral entry, but rather blocks membrane fusion. Our findings provide the first mechanistic insight into how a non-ACE2 blocking antibody potently neutralizes SARS-CoV-2, which may inform strategies for designing vaccines that robustly neutralize current and future SARS-CoV-2 variants.
Aligning of Single Walled Carbon Nanotubes Using a pH Responsive Poly (Acrylic Acid) as a Surfactant (2008)

Aligning of single walled carbon nanotubes has been shown to significantly enhance electrical and mechanical properties in polymer composites. Here, we report a novel method of using Poly (acrylic acid) a pH responsive polymer that is known to control the stability and dispersion of single-walled carbon nanotubes (SWNTs) in aqueous solutions to stabilize the SWNTs and align them using an AC electric field. Tuning the pH of the PAA suspended solution changes the microstructure of the SWNTs from an intercalated state to an exfoliated state. Good dispersion and stability of the SWNTs was achieved at low pH as opposed to high pH. Applying an AC electric field led to good alignment and chain formation of SWNTs in the direction of the applied field. The pH of the solution and PAA concentration play a significant role in achieving good dispersion, alignment and chain formation. Electrical conductivity of the solutions as a function of microstructure was studied. Improvement in electrical conductivity with increase in frequency was observed. Future work will focus on further probing the effect of pH and PAA content, and conserving the achieved microstructures to process solid composite films.
Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate (2013)

ABSTRACT: Knowledge of the extent to which tibial plateau cartilage displays non-uniform mechanical topography under physiologi-cally relevant loading conditions is critical to evaluating the role of biomechanics in knee osteoarthritis. Cartilage explants from 21 tibial plateau sites of eight non-osteoarthritic female cadaveric knees (age: 41–54; BMI: 14–20) were tested in unconfined compression at 100 % strain/s. The elastic tangent modulus at 10 % strain (E10%) was calculated for each site and averaged over four geographic regions: not covered by meniscus (I); covered by meniscus—anterior (II); covered by meniscus—exterior (III); and covered by menis-cus—posterior (IV). A repeated-measures mixed model analysis of variance was used to test for effects of plateau, region, and their interaction on E10%. Effect sizes were calculated for each region pair. E10 % was significantly different (p &amp;lt; 0.05) for all regional compar-isons, except I–II and III–IV. The regional pattern of variation was consistent across individuals. Moderate to strong effect sizes were evident for regional comparisons other than I–II on the lateral side and III–IV on both sides. Healthy tibial cartilage exhibits signifi-cant mechanical heterogeneity that manifests in a common regional pattern across individuals. These findings provide a foundation for evaluating the biomechanical mechanisms of knee osteoarthritis. 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:370–375, 2013
Recombineering in Non‐Model Bacteria (2022)

The technology of recombineering, in vivo genetic engineering, was initially developed in Escherichia coli and uses bacteriophage-encoded homologous recombination proteins to efficiently recombine DNA at short homologies (35 to 50 nt). Because the technology is homology driven, genomic DNA can be modified precisely and independently of restriction site location. Recombineering uses linear DNA substrates that are introduced into the cell by electroporation; these can be PCR products, synthetic double-strand DNA (dsDNA), or single-strand DNA (ssDNA). Here we describe the applications, challenges, and factors affecting ssDNA and dsDNA recombineering in a variety of non-model bacteria, both Gram-negative and -positive, and recent breakthroughs in the field. We list different microbes in which the widely used phage λ Red and Rac RecET recombination systems have been used for in vivo genetic engineering. New homologous ssDNA and dsDNA recombineering systems isolated from non-model bacteria are also described. The Basic Protocol outlines a method for ssDNA recombineering in the non-model species of Shewanella. The Alternate Protocol describes the use of CRISPR/Cas as a counter-selection system in conjunction with recombineering to enhance recovery of recombinants. We provide additional background information, pertinent considerations for experimental design, and parameters critical for success. The design of ssDNA oligonucleotides (oligos) and various internet-based tools for oligo selection from genome sequences are also described, as is the use of oligo-mediated recombination. This simple form of genome editing uses only ssDNA oligo(s) and does not require an exogenous recombination system. The information presented here should help researchers identify a recombineering system suitable for their microbe(s) of interest. If no system has been characterized for a specific microbe, researchers can find guidance in developing a recombineering system from scratch. We provide a flowchart of decision-making paths for strategically applying annealase-dependent or oligo-mediated recombination in non-model and undomesticated bacteria. © 2022 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. Basic Protocol: ssDNA recombineering in Shewanella species Alternate Protocol: ssDNA recombineering coupled to CRISPR/Cas9 in Shewanella species.
Editorial Comment (1995)

The past year has brought some changes for Seed Science Research.Firstly, as a result of a perceived need by seed ecologists for a publication outlet the remit of the journal has been expanded to accommodate papers in this area.Editorial supervision is in the hands of Ken Thompson, a new Associate Editor.Response to this innovation was first marked in the September issue by the appearance of a seed ecology section, and we anticipate a growth in the submission of research papers and review articles for the enlargement of this section.Secondly, the journal is now listed by the Institute for Scientific Information in Current Contents and its other indexes, which will bring Seed Science Research and the papers published therein to a much wider circle of potential readers and interested researchers.The year has been a busy one for seed scientists.Two international meetings, ISTA in Copenhagen and the Fifth International Seed Workshop in Reading, together attracted a large number of participants, a sign that the world of seed-based research is an active, vigorous and viable one: and Seed Science Research will continue as an important publication medium for this community.In doing so, it will rely on the contributions of the Editorial Board and many reviewers, all of whom have given of their precious time to referee papers, and on the support of the production staff of our publishers.I record my thanks to all of these for their work in 1995, and I look forward to a new year of increased success for our journal.
F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria (2019)

Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation, but the underlying ionic mechanism for this association remains unclear. We recently reported that expression of the small-conductance calcium-activated potassium channel 2 (SK2, encoded by <i>KCCN2</i>) in atria from diabetic mice is significantly down-regulated, resulting in reduced SK currents in atrial myocytes from these mice. We also reported that the level of SK2 mRNA expression is not reduced in DM atria but that the ubiquitin-proteasome system (UPS), a major mechanism of intracellular protein degradation, is activated in vascular smooth muscle cells in DM. This suggests a possible role of the UPS in reduced SK currents. To test this possibility, we examined the role of the UPS in atrial SK2 down-regulation in DM. We found that a muscle-specific E3 ligase, F-box protein 32 (FBXO-32, also called atrogin-1), was significantly up-regulated in diabetic mouse atria. Enhanced FBXO-32 expression in atrial cells significantly reduced SK2 protein expression, and siRNA-mediated FBXO-32 knockdown increased SK2 protein expression. Furthermore, co-transfection of SK2 with FBXO-32 complementary DNA in HEK293 cells significantly reduced SK2 expression, whereas co-transfection with atrogin-1ΔF complementary DNA (a nonfunctional FBXO-32 variant in which the F-box domain is deleted) did not have any effects on SK2. These results indicate that FBXO-32 contributes to SK2 down-regulation and that the F-box domain is essential for FBXO-32 function. In conclusion, DM-induced SK2 channel down-regulation appears to be due to an FBXO-32-dependent increase in UPS-mediated SK2 protein degradation.
In Vitro Study of HA and CMP Grit-Blasted and Acid Etched of Ti Surface (2006)

Grit-blasting using bioactive HA and biodegradable CMP followed by acid etching was done. The apatite formation of prepared Ti samples was evaluated by immersion in R-SBF. And cell viability, proliferation, and differentiation were conducted using MTT assay and ALP staining. In RSBF immersion tests, non-etched HA-blasted samples showed the faster apatite-like formation than other samples. Acid etched and non-etched HA-blasted samples showed better cell viability and proliferation compared to CMP-blasted samples after 1 and 3 days. And the cell differentiation of non-etched HA-blasted samples was better compared to etched ones, and etched and non-etched CMP-blasted samples.
Optical learning neurochip with internal analog memory (1993)

An optical neurochip with learning capability and a memory function is reported for the first time, to our knowledge. The neurochip is a three-dimensional optoelectronic integrated circuit consisting of a light-emitting diode array and a variable-sensitivity photodetector array. The principle of operation and the fundamental characteristics of the neurochip are described in detail. The synaptic weights, which, are acquired through learning, are stored in the variable-sensitivity photodetector as the detection sensitivity with analog values. Both the positive and the negative synaptic weights are memorized with one variable-sensitivity photodetector element by changing the polarity of the electric signal applied to the photodetector. A storage time of ~20 min. was obtained. With a fabricated optical neurochip that had 32 neurons and 32 x 32 synapses, experiments of on-chip learning for pattern classification were performed successfully.
Switching on a Signaling Pathway with an Organoruthenium Complex (2005)

Wie ein organisches Molekül! Ein chemisch inerter Rutheniumkomplex, der die Proteinkinase GSK-3 an ihrer ATP-Bindungsstelle inhibiert, schaltet den Wnt-Signalweg in lebenden Zellen und in Xenopus-Embryos ein. Diese entwickeln bei Verabreichung des neuen Metallopharmazeutikums einen hyperdorsalisierten Phänotyp (im Bild oben; unten: Kontrollexemplar). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z462501_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Table S4 from Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group (2023)

&lt;p&gt;Clinical characteristics of COG patients, according to treatment group, for all patients and for those genotyped for KIR/KIR-ligand.&lt;/p&gt;
Second Test Coil for the Development of a Compact 3 T $ \hbox{MgB}_{2}$ Magnet (2012)

The authors have reported the results of low n -value from a MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> test coil developed a year ago. A second test coil has been developed with wire of different structure and manufacturing process. Although the n-value related voltage of the second test coil was lower than the first test coil at designed current, it still showed low n-value. A third test coil has been wound with reduced mechanical stress. It also showed very similar n-value related voltage and n-value. Investigation of voltage distribution over the coil indicated that magnetic field was the major factor causing degradation of the n-value and resulting in n -value related voltages. Since the n-value related coil voltages were on the order of 0.1 μV/cm, the usual short sample <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> test (1 μV/cm was the definition of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ) might not detect the n-value related voltage and might not be able to investigate the cause of low n -value. Therefore, the medium length ( ~ 10 m) samples were tested and they showed the wire's lengthwise nonuniformity both on n-value and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> , which might be another potential cause of the low n-value of the coil. Along with the electrical investigation, the manufacturing process of the wire was carefully inspected for longitudinal uniformity. Some wire segment samples from the same batch exhibited nonuniformity in the particle size distribution resulting in nonuniform filaments. This might have occurred in the wire for the second and third test coils.
Characterization of propagation in an outdoor-to-indoor scenario at 780 MHz (2010)

In this paper, the results of outdoor-to-indoor multiple-input multiple-output (MIMO) channel measurements at 780 MHz are presented. The motivation for these measurements was to provide actual measurement data needed to extend the International Mobile Telecommunications -Advanced (IMT-A) channel models to the frequencies around 400 - 900 MHz. There are publications reporting measurement results for these frequencies, but the results for the outdoor-to-indoor propagation scenario are basically non-existing. The measurement results presented in this paper include path loss, shadow fading, delay spread, Ricean K-factor and angular spread. The cross-correlations between large scale parameters are also given. The path loss results were compared to two modified versions of COST 231 path loss model for building penetration loss. The comparison showed that the COST 231 path loss model with modified indoor and outdoor loss sections can be applied also to frequencies around 800 MHz with suitable parameter values.
Methodology for Device, Circuit and Architecture Level Co-design and Optimization of Dense Wavelength Division Multiplexing Links (2023)

We present a Dense Wavelength Division Multiplexing (DWDM) statistical model for study and optimization of device, circuit, and link architecture parameters. Using the model, we explore the rich space of DWDM parameters and some fundamental tradeoffs in design of such systems, as well as the often-neglected interdependence between low level device behavior and the link performance.
Further Analysis of a Cooper Pair Insulator (2010)

Submitted for the MAR10 Meeting of The American Physical Society Further Analysis of a Cooper Pair Insulator1 S.M. HOLLEN, H.Q. NGUYEN, M.D. STEWART, JR, J. SHAINLINE, Brown University Physics Department, AIJUN JIN, J.M. XU, Brown University Division of Engineering, J.M. VALLES, JR, Brown University Physics Department — Amorphous thin films of Bi deposited on a substrate with a Nano-Honeycomb (NHC) array of holes can exhibit a Cooper Pair Insulator (CPI) phase [1]. The transport in this state is dominated by the incoherent tunneling of Cooper Pairs between localized states. The resistivity is activated in temperature, and the magnetoresistance (MR) near the thickness-tuned Superconductor-Insulator Transition (SIT) exhibits a giant peak, as is found in thin films of InOx and TiN. In an effort to learn how the localization of pairs develops, we have investigated films deposited on substrates with different hole radii, order in the hole arrays, and surface roughness. We will present our latest findings on the common features describing the CPI phase, and how the above variations influence its properties and those of the thickness-tuned SIT in these amorphous films. [1] M. D. Stewart Jr., A. Yin, J. M. Xu, and J. M. Valles Jr., Science 318, 1273 (2007). 1This work was supported by the NSF through No. DMR-0203608 and No. DMR0605797, by the AFRL, and by the ONR. Shawna Hollen Brown University Date submitted: 18 Nov 2009 Electronic form version 1.4
Editorial: Fetal/Embryonic Hematopoietic Progenitors and Their Impact on Adult Diseases (2021)

EDITORIAL article Front. Cell Dev. Biol., 18 August 2021 | https://doi.org/10.3389/fcell.2021.732649
SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression (2013)

Survivin, a member of the IAP (inhibitor of apoptosis) gene family, is overexpressed in virtually all human cancers and is functionally involved in the inhibition of apoptosis, regulation of cell proliferation, metastasis and resistance to therapy. Because of its upregulation in malignancy, survivin has currently attracting considerable interest as a new target for anticancer therapy. In a screening of approximately 200 strains of imperfect fungi for the production of inhibitors of survivin promoter activity, a new drimane sesquiterpene lactone, SF002-96-1, was isolated from fermentations of an Aspergillus species. The compound inhibited survivin promoter activity in transiently transfected Colo 320 cells in a dose dependent manner with IC50 values of 3.42 µM (1.3 µg/mL). Moreover, it also reduced mRNA levels and protein synthesis of survivin and triggered apoptosis.