gebhart/patrepeval huggingface dataset:
673: Utility of Resection of Additional Peri-Prostatic Tissue in Patients Undergoing Radical Prostatectomy (2006)

You have accessJournal of UrologyDiscussed Poster, Monday, May 22, 2006, 9:00 am - 12:00 pm1 Apr 2006673: Utility of Resection of Additional Peri-Prostatic Tissue in Patients Undergoing Radical Prostatectomy Ganesh V. Raj, Rahul Iyer, Fernando J. Bianco, Bertrand Guillonneau, Peter T. Scardino, Victor E. Reuter, Samson W. Fine, and James A. Eastham Ganesh V. RajGanesh V. Raj More articles by this author , Rahul IyerRahul Iyer More articles by this author , Fernando J. BiancoFernando J. Bianco More articles by this author , Bertrand GuillonneauBertrand Guillonneau More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , Victor E. ReuterVictor E. Reuter More articles by this author , Samson W. FineSamson W. Fine More articles by this author , and James A. EasthamJames A. Eastham More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32919-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "673: Utility of Resection of Additional Peri-Prostatic Tissue in Patients Undergoing Radical Prostatectomy." The Journal of Urology, 175(4S), p. 217 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 217 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ganesh V. Raj More articles by this author Rahul Iyer More articles by this author Fernando J. Bianco More articles by this author Bertrand Guillonneau More articles by this author Peter T. Scardino More articles by this author Victor E. Reuter More articles by this author Samson W. Fine More articles by this author James A. Eastham More articles by this author Expand All Advertisement Loading ...
Phantom and Solenoid Coil Development For Induced Current Electro-Thermal Imaging (2021)

Tumorous tissues generate more metabolic heat than healthy tissues, in case where the tumor tissue is close to the surface, it is possible to detect the tumor with thermal infrared imaging methods. Deeper tumors can be imaged by increasing the temperature of the tumorous tissue by the externally applied magnetic field. In the simulation study, breast and cancerous tissue were modeled in three dimensions by using realistic values of the tissues. Current was induced with a solenoid coil and temperature changes in the breast model were observed by simulations. At 750 kHz operating frequency, the current that can be applied to the coil, according to the specific absorption rate (SAR) limit value of 10 W/kg, was found 66.5 A. The coil designed in the simulations was realized to be used in the experiments. A series resonant circuit and a power amplifier were used to energize the coil with the desired current value. Gelatin-based and vegetable-made phantoms with added NaCI were developed to observe the effect of the coil on the breast model. Thus, the coil circuit designed in the simulation and the suitable tumor tissue phantom are realized.
The design, development and performance of a Duplex Stirling natural gas liquefier (1982)

The idea of using a Duplex Stirling System for natural gas liquefaction has long been considered by Sunpower as an attractive application for Stirling engines. A few years ago an internally funded project was embarked upon to build a small demonstration Duplex Stirling unit. This machine was designed around the Model M-100 engine which was then being produced commercially. The demonstrator machine first ran in 1979 and soon proved to be a stable and reliable performer. A series of three further machines incorporating various improvements and modifications followed at which point it was confidently felt that the design of a large machine of more realistic capacity could be attempted. Work was started in August 1981 on the design and development of a preproduction natural gas liquefier with a capacity of at least 4 1/hr. The design of the larger machine borrows extensively from the experience gained from the small prototype machines. Scaling, computer simulation and optimization are used to refine the design. Presented here is a summary of the design and development of the preproduction machine.
Correlation between the Dynamics of Nanoconfined Water and the Local Chemical Environment in Calcium Silicate Hydrate Nanominerals (2021)

Calcium silicate hydrates are members of a large family of minerals with layered structures containing pendant CaOH and SiOH groups that interact with confined water molecules. To rationalize the impact of the local chemical environment on the dynamics of water, SiOH- and CaOH-rich model nanocrystals were synthesized by using the continuous supercritical hydrothermal method and then systematically studied by a combination of spectroscopic techniques. In our comprehensive analysis, the ultrafast relaxation dynamics of hanging hydroxy groups can be univocally assigned to CaOH or SiOH environments, and the local chemical environment largely affects the H-bond network of the solvation water. Interestingly, the ordered "ice-like" solvation water found in the SiOH-rich environments is converted to a disordered "liquid-like" distribution in the CaOH-rich environment. This refined picture of the dynamics of confined water and hydroxy groups in calcium silicate hydrates can also be applied to other water-containing materials, with a significant impact in many fields of materials science.
Geometrical Characteristics of Left Ventricular Dyssynchrony in Advanced Heart Failure (2014)

The aims of this study were to quantify the geometrical differences in left ventricular (LV) dyssynchrony in patients with heart failure (HF) using cine-tagged MRI, and to investigate the relationship between dyssynchrony and major adverse cardiac events (MACE) in HF.In 67 patients with HF [mean LV ejection fraction (LVEF), 34%], cardiac MRI using a 3-Tesla scanner was performed. The dyssynchrony time between septal and lateral segments (SL-DT) and between basal and apical segments (BA-DT) was computed by cross-correlation analysis of the strain time-curves from the cine-tagged MRI. After receiving optimal medical treatment, all patients were followed-up for a mean period of 27 months. The primary endpoint was MACE that consisted of cardiac death or HF hospitalization or a left ventricular assist device due to refractory pump failure. Multivariate logistic regression analysis was performed to determine the ability of SL-DT, BA-DT, and HF biomarkers to predict MACE.Multivariate logistic regression analysis showed that the odds ratio to predict MACE was 0.935 for LVEF (P = 0.021), 1.016 for BA-DT (P = 0.026), and 0.971 for systolic blood pressure (P = 0.126).The results show that basal-apical dyssynchrony is an independent predictor of MACE in HF patients.
PROGRAMS FOR CALCULATING RELATIVE INTENSITIES IN THE VIBRATIONAL STRUCTURE OF ELECTRONIC BAND SYSTEMS (1963)

Source-deck listings of two computer programs are given for the calculation of relative intensities in the vibrational structure of an electronic transition. The first program finds turning points of an electronic potentialenergy curve by direct numerical evaluation of the Klein action integrals in the RKR procedure. The second program uses these turnlng points to construct an effective potential for the molecule with rotational quantum number J. The radial Schrodinger equation then is solved for this potential to yield vibrational-rotational wavefunctions from which the program calculates Franck- Condon factors, rcentroids, and relative intensities. Sample input and output are included. (auth)
Structure of [μ-S2{Ru(PCy3)('S4')}2] · 2.5 THF ·0.5 Et2O Containing Homochiral Metal Complex Fragments ['S4'2- = 1,2-Bis(mercaptophenylthio)-ethane (2-)] (1999)

A crystal of the title compound [μ-S 2 {Ru(PCy 3 )(′S 4 ′)} 2 ] · 2.5 THF · 0.5 Et 2 O (1 · 2.5 THF · 0.5 Et 2 O), grown from a THF/Et 2 O solution, was investigated by single-crystal X-ray analysis. 1 · 2.5 THF · 0.5 Et 2 O crystallizes in the triclinic space group P1̄ with a = 14.209(4), b = 15.390(4), c = 19.526(6) Å, α = 111.29(2), ß = 100.43(2), γ = 95.65(2)°, and Z = 2. The crystal structure was solved by direct methods (wR 2 = 0.1520 for 12565 reflections; R 1 = 0.0507 for 9205 observed reflections). The molecular structure of 1 · 2.5 THF · 0.5 Et 2 O is characterized by a trans η 1 -η 1 -S 2 bridge connecting two homochiral [Ru(PCy 3 )(′S 4 ′)] fragments. The S-S bond length of 1.982(2) Å and a mean Ru-S(bridge) distance of 2.234(2) Å indicate partial double bond character of these bonds. The RuSSRu unit in 1 · 2.5 THF · 0.5 Et 2 O is a chromophore as indicated by its UV spectrum and can be described by a delocalized 4c-6e 7π system.
Investigation of Conducting Oxide and Metal Electrode Work Functions on Lanthanum Silicate High-k Dielectric (2007)

The effective work functions (EWF) of thin transparent conducting oxide (TCO) interlayers, i.e. indium tin oxide (ITO) and indium zinc tin oxide (IZTO), on lanthanum silicate metal-insulator-semiconductor (MIS) devices were examined. The properties were compared to those obtained using conventional metal electrodes. It was found that the EWF of all metal gates investigated was lowered by ~0.3 - 0.4 compared to expected values, due to effects related to the lanthanum silicate dielectric stack. The presence of the TCO electrode layer yielded EWF values ranging from 4.05 to 4.45 eV depending primarily on the annealing condition, regardless of the TCO type. As it is known that ITO can have a work function ~4.75 eV, the presence of the oxide electrode still results in an EWF ~0.3 - 0.4 eV below expected values. These results indicate that EWF lowering in lanthanum silicate gate stacks is not strongly dependent on the top interface.
Effects of Base Analog Substitutions in the Noncoding dC of the 3'-d(CTG)-5' Template Recognition Site of the Bacteriophage T7 Primase (1995)

The 63-kDa gene 4 protein (DNA primase) of bacteriophage T7 catalyzes the synthesis of the oligoribonucleotides pppACC(C/A) and pppACAC at single-stranded DNA recognition sites 3'-d[CTGG-(G/T)]-5' and 3'-d(CTGTG)-5', respectively. At these sites, the 3'-terminal deoxycytidine residue is conserved but noncoding; the 3'-dC residue is required to initiate catalytic synthesis of oligoribonucleotides, yet it is not used as a template residue for the synthesis of a complementary G residue in the RNA primer. We have examined the interactions between T7 primase and the functional groups of the 3'-dC residue by measuring the ability of the primase to catalyze the synthesis of oligoribonucleotides on synthetic single-stranded 20-mer templates [e.g., 3'-d(GCTATGGTGACTGGTAGTCG)-5'] that contain analogs of dC in the conserved pentanucleotide recognition site. Recognition sites containing 5-methyldeoxycytidine (m5dC) or 1-(beta-D-2'-deoxyribosyl)-2-pyrimidinone (dH4C) substitutions for dC support oligoribonucleotide synthesis whereas those containing deoxythymidine (dT) and deoxyuridine (dU) substitutions do not. Oligoribonucleotide synthesis on the native template (containing dC) is inhibited competitively by the template containing a dT residue in the primase recognition site, 3'-[(N10)TTGGT(N5)]-5', with an apparent Ki of 1.30 +/- 0.04 microM. Templates containing dU residues, 3'-[(N10)UTGGT(N5)]-5' and 3'-[(N9)UTTGGT-(N5)]-5', affect both the apparent Km and Vmax parameters for oligoribonucleotide synthesis on the 3'-[(N10)CTGGT(N5)]-5' template.
Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase (2019)

Citrullination is an essential post-translational modification in which the guanidinium group of protein and peptide arginines is deiminated by peptidylarginine deiminases (PADs). When deregulated, excessive citrullination leads to inflammation as in severe periodontal disease (PD) and rheumatoid arthritis (RA). Porphyromonas gingivalis is the major periodontopathogenic causative agent of PD and also an etiological agent of RA. It secretes a PAD, termed Porphyromonas PAD (PPAD), which is a virulence factor that causes aberrant citrullination. Analysis of P. gingivalis genomes of laboratory strains and clinical isolates unveiled a PPAD variant (PPAD-T2), which showed three amino-acid substitutions directly preceding catalytic Residue H<sup>236</sup> (G<sup>231</sup> N/E<sup>232</sup> T/N<sup>235</sup> D) when compared with PPAD from the reference strain (PPAD-T1). Mutation of these positions in the reference strain resulted in twofold higher cell-associated citrullinating activity. Similar to PPAD-T1, recombinant PPAD-T2 citrullinated arginines at the C-termini of general peptidic substrates but not within peptides. Catalytically, PPAD-T2 showed weaker substrate binding but higher turnover rates than PPAD-T1. In contrast, no differences were found in thermal stability. The 1.6 Å-resolution X-ray crystal structure of PPAD-T2 in complex with the general human PAD inhibitor, Cl-amidine, revealed that the inhibitor moiety is tightly bound and that mutations localize to a loop engaged in substrate/inhibitor binding. In particular, mutation G<sup>231</sup> N caused a slight structural rearrangement, which probably originated the higher substrate turnover observed. The present data compare two natural PPAD variants and will set the pace for the design of specific inhibitors against P. gingivalis-caused PD.
Manipulation of Photons Based on Various Engineering in Photonic Crystals (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Noda, "Manipulation of Photons Based on Various Engineering in Photonic Crystals," in Photonic Metamaterials: From Random to Periodic, Technical Dgest (CD) (Optica Publishing Group, 2006), paper MC2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Response to Miner et al. (2017)

Currie, Mark G PhD; Shiff, Steven J MD; Schneier, Harvey A MD; Johnston, Jeffrey M MD Author Information
Supplementary Table 1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma (2023)

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Calcium-dependent oligonucleotide antagonists specific for L-selectin. (1996)

The selectins are calcium-dependent C-type lectins that recognize complex anionic carbohydrate ligands, initiating many cell-cell interactions in the vascular system. Selectin blockade shows therapeutic promise in a variety of inflammatory and postischemic pathologies. However, the available oligosaccharide ligand mimetics have low affinities and show cross-reaction among the three selectins, precluding efficient and specific blockade. The SELEX (systematic evolution of ligands by exponential enrichment) process uses combinatorial chemistry and in vitro selection to yield high affinity oligonucleotides with unexpected binding specificities. Nuclease-stabilized randomized oligonucleotides subjected to SELEX against recombinant L-selectin yielded calcium-dependent antagonists with approximately 10(5) higher affinity than the conventional oligosaccharide ligand sialyl LewisX. Most of the isolated ligands shared a common consensus sequence. Unlike sialyl LewisX, these antagonists show little binding to E- or P-selectin. Moreover, they show calcium-dependent binding to native L-selectin on peripheral blood lymphocytes and block L-selectin-dependent interactions with the natural ligands on high endothelial venules.
Seeded Synthesis of CdSe/CdS Rod and Tetrapod Nanocrystals (2013)

We demonstrate a method for the synthesis of multicomponent nanostructures consisting of CdS and CdSe with rod and tetrapod morphologies. A seeded synthesis strategy is used in which spherical seeds of CdSe are prepared first using a hot-injection technique. By controlling the crystal structure of the seed to be either wurtzite or zinc-blende, the subsequent hot-injection growth of CdS off of the seed results in either a rod-shaped or tetrapod-shaped nanocrystal, respectively. The phase and morphology of the synthesized nanocrystals are confirmed using X-ray diffraction and transmission electron microscopy, demonstrating that the nanocrystals are phase-pure and have a consistent morphology. The extinction coefficient and quantum yield of the synthesized nanocrystals are calculated using UV-Vis absorption spectroscopy and photoluminescence spectroscopy. The rods and tetrapods exhibit extinction coefficients and quantum yields that are higher than that of the bare seeds. This synthesis demonstrates the precise arrangement of materials that can be achieved at the nanoscale by using a seeded synthetic approach.
Verification of a Method of Detecting Life-threatening Arrhythmias from Human Data for Use in Implantable Cardioverter-Defibrillator (2014)

The implantable cardioverter-defibrillator is an effective therapeutic device for preventing death from life-threatening arrhythmias such as ventricular tachycardia and ventricular fibrillation in patients with cardiac diseases. It is important to prevent their recurrence and treat these arrhythmias as early as possible. It is also essential to accurately distinguish among normal sinus rhythm, ventricular tachycardia, ventricular fibrillation, and supraventricular tachycardia. Therefore, in this study, we proposed a classification method that uses multiple regression model based on information extracted from simultaneous intracardiac electrocardiograms, to identify episodes of sinus rhythm, supraventricular tachycardia, and ventricular tachycardia from human intracardiac electrocardiograms. From the results of validation, we confirmed that the proposed method is able to distinguish shockable cardiac rhythms from nonshockable cardiac rhythms based on indices obtained from simultaneous intracardiac electrocardiograms.
A Riddle Wrapped in an Enigma (2016)

In August 2015, the NSA released a major policy statement on the need for postquantum cryptography (PQC). This announcement will be a great stimulus to the development, standardization, and commercialization of new quantum-safe algorithms. However, certain peculiarities in the statement's wording and timing have given rise to much speculation concerning the NSA, elliptic curve cryptography, and quantum-safe cryptography. In this article, the authors evaluate some of the theories that have been proposed.
Devising a glycoantigen specific DC immunotherapy to develop an efficient anti-tumor response within the hypoxic environment of glioblastoma (TUM2P.1026) (2015)

Abstract Glioblastoma (GBM) is the most malignant type of brain tumor, its therapy hindered by the hypoxic microenvironment that promotes tumor resistance and inhibits immune cell function. We propose combining dendritic cell (DC) immunotherapy with hypoxia reversal to eradicate GBM. HIF-1α, a transcription factor that stimulates genes promoting angiogenesis and tumor growth, was expressed in both GBM cells and DCs under hypoxia. Hypoxia also downregulated expression of HLA-DR, CD86 and HLA-ABC on DCs affecting their antigen processing and presentation capability in addition to reducing the generation of pro-inflammatory cytokines such as TNF- α and IL-6. In vivo imaging revealed fluorescently labeled DCs migrating away from site of injection into spleen and mediastinal lymph nodes of mice with GBM indicating chemoattraction of DCs to areas of inflammation post hypoxia reversal using using antisense HIF-1α plasmid. In order to identify tumor antigens we used glycan analysis wherein GlcNAc was overexpressed in hypoxic GBM cells. We then enriched GlcNAc expressing glycoantigens and identified 46 glycopeptides derived from 33 glycoproteins. Amongst them Lamb1, SerpinH1, CD63 and others are associated with tumor survival, progression, invasion, immune evasion and therapy resistance. Lectins expressed on DCs complimentary to these glycans will be identified to devise a DC based vaccine, which in conjunction with hypoxia reversal will augment the efficacy of existing therapies against GBM.
Remutualizing the Musical Instrument: Co-Design of Synthesis Algorithms and Controllers (2004)

From the advent of electronic music, and even from early organ consoles and other remote manipulated instruments, much of the design and research of new musical interfaces has focused on abstracting (both physically and in the design process) the “controller” from the “synthesizer” and then investigating how to best interface those two classes of hardware with each other and the player. Yet, many of the striking lessons from our history of intimate expressive musical instruments lie in the blurred boundaries between player, controller, and sound producing object. Bowed strings, winds, and certainly the human voice all blur these boundaries, both in the design and construction of the “instrument” and in the resulting controls and expressions. This article looks at some of the issues involved with creating new expressive electronic musical instruments, and presents an overview of a number of recent projects in the co-design of musical controllers and computer sound synthesis algorithms. Specific cases are described where the traditional engineering approach of building a controller (a box), and connecting it to a synthesizer (another box) would never have yielded the final product that resulted from the tightly coupled development of a complete musical system all at the same time. Examples are given of where a discovery from synthesis algorithm development suggested a new control metaphor, and where a control component suggested a new aspect of synthesis.
Polyurethanes. III. The effects of aromatic rings on the structure and properties of polyurethanes based on ethylene glycol (1965)

Abstract A series of aromatic polyurethanes based on ethylene glycol and two of their aliphatic analogs were synthesized and some of their physical properties determined. Polymer chain conformations are proposed which are consistent with X‐ray diffraction data. The polyurethane from diaminodiphenylmethane and ethylene glycol has a twisted chain conformation. This is in contrast to other polyurethanes examined which closely resemble their polyamide counterparts. The melting temperatures and glass transition temperatures of the polyurethanes are shown to be affected by chain stiffening resulting from the presence of the aromatic rings, as well as by the conformation of the polymer chains.
ChemInform Abstract: Phosphonium Coupling in the Direct Bond Formations of Tautomerizable Heterocycles via C—OH Bond Activation. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Beyond Capacity: The Joint Time-Rate Region (2021)

The traditional notion of capacity studied in the context of memoryless network communication builds on the concept of block-codes and requires that, for sufficiently large blocklength n, all receiver nodes simultaneously decode their required information after n channel uses. In this work, we generalize the traditional capacity region by exploring communication rates achievable when some receivers are required to decode their information before others, at different predetermined times; referred here as the "time-rate" region. Through a reduction to the standard notion of capacity, we present an inner-bound on the time-rate region. The time-rate region has been previously studied and characterized for the memoryless broadcast channel (with a sole common message) under the name "static broadcasting".