gebhart/patrepeval huggingface dataset:
Measurement of Raman Spectra for Tomographic Reconstruction (2012)

Raman signal is measured through a tomography set-up with 8 distinct spectrometers allowing for increased spectral resolution. Reconstructed images show good localization and contrast of Raman signal to background for Teflon inclusions within gelatin-based phantoms.
1550nm All-Fiber Interferometer For Partial Discharge Detection In Oil-Insulated Power Transformer (2006)

A fiber-interferometric sensor realized with standard telecommunication components operating at 1550nm is developed to detect acoustic emissions from partial discharges in oil- insulated transformers. Sensor performance is compared with typical electric measurement in realistic harsh environment.
A modular approach to the design and analysis of authentication and key exchange protocols (extended abstract) (1998)

Article Free Access Share on A modular approach to the design and analysis of authentication and key exchange protocols (extended abstract) Authors: Mihir Bellare Department of Computer Science & Engineering, Mail Code 0114, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA Department of Computer Science & Engineering, Mail Code 0114, University of California at San Diego, 9500 Gilman Drive, La Jolla, CAView Profile , Ran Canetti IBM T.J. Watson Research Center, PO Box 704, Yorktown Heights, New York IBM T.J. Watson Research Center, PO Box 704, Yorktown Heights, New YorkView Profile , Hugo Krawczyk Department of Electrical Engineering, Technion, Haifa 32000, Israel and IBM T.J. Watson Research Center, New York Department of Electrical Engineering, Technion, Haifa 32000, Israel and IBM T.J. Watson Research Center, New YorkView Profile Authors Info & Claims STOC '98: Proceedings of the thirtieth annual ACM symposium on Theory of computingMay 1998Pages 419–428https://doi.org/10.1145/276698.276854Published:23 May 1998Publication History 264citation2,464DownloadsMetricsTotal Citations264Total Downloads2,464Last 12 Months215Last 6 weeks25 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Organization of Serpin Gene-1 from Manduca sexta (1996)

Manduca sexta serpin gene-1 encodes a family of serpins whose amino acid sequences are identical in their amino-terminal 336 residues but variable in their carboxyl-terminal 39-46 residues, which includes the reactive site loop (Jiang, H., Wang, Y., and Kanost, M. R. (1994) J. Biol. Chem. 269, 55-58). Here, we report the gene's complete nucleotide sequence and exon-intron structure. A unique characteristic of this gene is its exon 9, which is present in 12 alternate forms between exons 8 and 10. Isolation and characterization of cDNA clones containing exons 9C, 9H, and 9I, which were not found previously, indicate that all 12 alternate forms of exon 9 can be utilized to generate 12 different serpins. The splicing pathway apparently allows inclusion of only one exon 9 per molecule of mature serpin-1 mRNA. Analysis of exon-intron border sequences reveals unique features that may be involved in regulation of RNA splicing. The exon 9 region has apparently evolved through rounds of exon duplication and sequence divergence. The exons near the center of the region may have evolved recently, whereas the outermost exons are the most ancient. Exons 9G and 9H were duplicated as a pair from exons 9E and 9F, an event that may have occurred more than once in the history of this gene.
Fibrosis explains atrial fibrillation recurrences after pulmonary vein isolations. A simulation study (2019)

International audience
MicroRNA‐125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection (2017)

Assessing tissue miR-125b-5p expression and IM is useful for stratifying patients at risk of early HCC recurrence after curative resection.
Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation. (1996)

Haploidentical bone marrow transplantation (BMT) is associated with a high risk of severe graft-versus-host disease (GVHD). While pan-T cell depletion of the graft is the most effective means of preventing severe GVHD, it is associated with delayed recovery of T cell function leading to fatal infections. We used two related Pseudomonas exotoxin-based immunotoxins, anti-Tac(Fv)-PE38 and anti-Tac(Fv)-PE38KDEL, that both target the IL-2 receptor on activated T cells, to specifically deplete alloreactive lymphocytes against haploidentical stimulators. The functional capacity of the remaining lymphocytes was tested in proliferative assays against the original haploidentical stimulator and pooled cells from other mismatched donors (third party). We varied the recombinant toxin concentration and schedule to determine the optimum conditions for selective depletion. In 10 experiments, the mean residual reactivity after depletion was 7.6 +/- 1.4% against the haploidentical stimulator and 64.2 +/- 5% against the third party, expressed as a percentage of the undepleted response to the same stimulators. Depletion was shown to be specific for mixed lymphocyte culture (MLC)-activated lymphocytes. The immunotoxin did not affect CFU-GM growth of normal BM cells. This selective depletion of haploidentical alloreactivity could be used to prevent GVHD while conserving immune recovery following haploidentical BMT.
Growth of Shape-Controlled Ca3NbGa3Si2O14 and Sr3NbGa3Si2O14 Single Crystals by Micro-Pulling-Down Method and Their Physical Properties (2011)

Shape-controlled langasite-type piezoelectric single crystals, Ca 3 NbGa 3 Si 2 O 14 (CNGS) and Sr 3 NbGa 3 Si 2 O 14 (SNGS), were grown by the micro-pulling-down (µ-PD) method and their physical properties were investigated. Columnar-shaped CNGS and SNGS crystals with a - and c -axes in the growth direction were grown and the diameters of the grown columnar-shaped crystals were controlled to be approximately 3 mm from the initial to the later part. The grown crystals without cracks indicated relatively high crystallinities and a single phase of the langasite-type structure in the powder X-ray diffraction patterns. Meanwhile, in the outside area of the crystals, parts of second phases were detected and energy dispersive X-ray spectroscopy measurements indicated that the second phases of the CNGS and SNGS crystals were the Ca–Nb–O and Sr–Nb–O systems, respectively. The d 11 of the CNGS crystal indicated 3.98 pC/N, which was coincident with those of previous reports.
Indoor GPS Test Methodology and Indoor Performance Tests (2002)

An indoor GPS test methodology is presented in 
this paper. Test set-ups are considered wherein a 
controlled aiding environment is provided in the 
absence of target wireless infrastructure. True 
coordinates for reference points are established 
to sub-meter accuracy and with respect to these 
position errors are obtained. The test running and 
data post processing steps are automated to start 
test scenarios on various receivers. The 
automated process further takes care of data 
logging, session closing, data processing and 
finally web-based report generation. Some 
indoor test results are presented in the end.
PUBLIC INFORMATION AND KNOWLEDGE REQUISITES OF A SHELTER SYSTEM. Final Report. (1966)

We used DNA analysis of the freshwater Galaxias vulgaris complex (Pisces: Galaxiidae) to test a geological hypothesis of drainage evolution in South Island, New Zealand. Geological evidence suggests that the presently north-flowing Nevis River branch of the Clutha/Kawarau River system (Otago) once flowed south into the Nokomai branch of the Mataura system (Southland). The flow reversal is thought to have resulted from fault and fold activity associated with post-Miocene uplift. Mitochondrial DNA sequence data (control region and cytochrome b genes; 76 individuals; maximum divergence 7.1%) corroborate this geomorphological hypothesis: The Nevis River retains a freshwater fish species (Galaxias gollumoides; five sites; 10 haplotypes) that is otherwise restricted to Southland (nine sites; 15 haplotypes). There is no indication that the Nevis River lineage of G. gollumoides lives elsewhere in the Clutha/ Kawarau system (> 30 sites). Likewise, two widespread Clutha lineages (G. 'sp D'; G. anomalus-G. pullus) are apparently absent from the Nevis (> 30 sites). In particular, G. 'sp D' lives throughout much of the Clutha (12 sites, 23 haplotypes), including a tributary of the Kawarau, but is absent from the Nevis itself. Conventional molecular clock calibrations (based on a minimum Nevis-Mataura haplotype divergence of 3.0%) indicate that the Nevis flow reversal may have occurred in the early-mid Pleistocene, which is roughly consistent with geological data. The broad phylogeographic structure evident in the Clutha system is consistent with the sedentary nature of nonmigratory galaxiids. Our study reinforces the value of combining biological and geological data for the formulation and testing of historical hypotheses.
The Effect of the System Specification on the Optimal Selection of Clocked Storage Elements (2007)

This paper represents a departure from the conventional methods of design and analysis of clocked storage elements that rely on minimizing a fixed energy-delay metric. Instead it establishes a systematic comparison in the energy-delay design space based on the parameters of the surrounding blocks. We define the composite energy-efficient characteristic over all storage element topologies and identify the most efficient storage element depending on its position on the composite characteristic relative to other topologies within a pipeline stage. Thus, we show that an optimal design could use a mixed variety of clocked storage elements (CSEs) depending on their placement in the pipeline and critical path. Since a well-designed system has hardware intensities balanced for a given cycle, a CSE choice will be made depending on the pipeline and path intensities. We show that a meaningful comparison can be carried out only by acknowledging that the optimal design and choice of the clocked storage elements depends heavily on the application, and by analyzing the energy and delay of the clocked storage elements in context of this application. The analysis in the energy-delay space allows us to understand some intuitive design choices in a quantitative way and to identify the optimal storage element topologies for an arbitrary system specification
Raman scattering from surface phonons in GaN nanostructures (2013)

We study Raman scattering of GaN regularly-arrayed nanowalls, nanocolumns and nanorings, and observe a peak from surface phonons around 705 cm−1. The peak from the surface phonons in the nanocolumns is much broader than those in the nanowalls and nanorings, but is not observed when the diameter of column is thinner than 100 nm. This is explained in terms of quantization of the azimuthal wave vector on the circumference of columnar structure. In the nanorings, we observe a very weak peak from a surface phonon.
A portable and compact near-infrared spectral tomography system for predicting breast tumor response to neoadjuvant chemotherapy (2015)

A portable hybrid frequency domain (FD)-continuous wave (CW) Near-Infrared spectroscopy NIRS system has been developed for quantifying changes in total hemoglobin, oxygen saturation and water content in the breast during neoadjuvant chemotherapy. Simultaneous acquisition of two sets of 3 FD channels and 3 CW channels could be completed within 1 min. System calibration and homogeneous phantom measurement show phase variation less than 3% when PMT gain from 0.7 to 1.1 was used. The study of integrating this system into the workflow of clinical oncology practice is ongoing.
Bringing Genomes to Life: The Use of Genome-Scale In Silico Models (2008)

Metabolic network reconstruction has become an established procedure that allows the integration of different data types and provides a framework to analyze and map high-throughput data, such as gene expression, metabolomics,and fluxomics data. In this chapter, we discuss how to reconstruct a metabolic network starting from a genome annotation. Further experimental data, such as biochemical and physiological data, are incorporated into the reconstruction, leading to a comprehensive, accurate representation of the reconstructed organism, cell, or organelle. Furthermore, we introduce the philosophy of constraint-based modeling, which can be used to investigate network properties and metabolic capabilities of the reconstructed system. Finally, we present two recent studies that combine in silico analysis of an Eschirichia coli metabolic reconstruction with experimental data. While the first study leads to novel insight into E. coli's metabolic and regulatory networks, the second presents a computational approach to metabolic engineering.
Discovery of Polyoxo-Noble-Metalate-Based Metal–Organic Frameworks (2019)

Here we report on the synthesis, structure, and characterization of the first example of a polyoxopalladate (POP)-based metal-organic framework (MOF). This novel class of materials comprises discrete polyoxo-13-palladate(II) nanocubes [Pd<sub>13</sub>O<sub>8</sub>(AsO<sub>4</sub>)<sub>8</sub>H<sub>6</sub>]<sup>8-</sup> decorated by four Ba<sup>2+</sup> ions on each of two opposite faces. These secondary building units (SBUs) are linked to each other via rigid linear organic groups, resulting in a stable 3D POP-MOF framework, which exhibits interesting sorption as well as catalytic properties.
Performance Analysis of a Hybrid Raman Optical Parametric Amplifier in the O- and E-Bands for CWDM PONs (2014)

We describe a hybrid Raman-optical parametric amplifier (HROPA) operating at the O- and E-bands and designed for coarse wavelength division multiplexed (CWDM) passive optical networks (PONs). We present the mathematical model and simulation results for the optimization of this HROPA design. Our analysis shows that separating the two amplification processes allows for optimization of each one separately, e.g., proper selection of pump optical powers and wavelengths to achieve maximum gain bandwidth and low gain ripple. Furthermore, we show that the proper design of optical filters incorporated in the HROPA architecture can suppress idlers generated during the OPA process, as well as other crosstalk that leaks through the passive optical components. The design approach enables error free performance for all nine wavelengths within the low half of the CWDM band, assigned to upstream traffic in a CWDM PON architecture, for all possible transmitter wavelength misalignments (±6 nm) from the center wavelength of the channel band. We show that the HROPA can achieve error-free performance with a 170-nm gain bandwidth (e.g., 1264 nm–1436 nm), a gain of &gt;20 dB and a gain ripple of &lt;4 dB.
Monomeric C‐reactive protein and inflammation in age‐related macular degeneration (2016)

Age-related macular degeneration (AMD) is a devastating disease characterized by central vision loss in elderly individuals. Previous studies have suggested a link between elevated levels of total C-reactive protein (CRP) in the choroid, CFH genotype, and AMD status; however, the structural form of CRP present in the choroid, its relationship to CFH genotype, and its functional consequences have not been assessed. In this report, we studied genotyped human donor eyes (n = 60) and found that eyes homozygous for the high-risk CFH (Y402H) allele had elevated monomeric CRP (mCRP) within the choriocapillaris and Bruch's membrane, compared to those with the low-risk genotype. Treatment of choroidal endothelial cells in vitro with mCRP increased migration rate and monolayer permeability compared to treatment with pentameric CRP (pCRP) or medium alone. Organ cultures treated with mCRP exhibited dramatically altered expression of inflammatory genes as assessed by RNA sequencing, including ICAM-1 and CA4, both of which were confirmed at the protein level. Our data indicate that mCRP is the more abundant form of CRP in human choroid, and that mCRP levels are elevated in individuals with the high-risk CFH genotype. Moreover, pro-inflammatory mCRP significantly affects endothelial cell phenotypes in vitro and ex vivo, suggesting a role for mCRP in choroidal vascular dysfunction in AMD. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Nanoscience and Nanotechnology Impacting Diverse Fields of Science, Engineering, and Medicine (2016)

Author(s): Chan, Warren WC; Chhowalla, Manish; Glotzer, Sharon; Gogotsi, Yury; Hafner, Jason H; Hammond, Paula T; Hersam, Mark C; Javey, Ali; Kagan, Cherie R; Khademhosseini, Ali; Kotov, Nicholas A; Lee, Shuit-Tong; Li, Yan; Möhwald, Helmuth; Mulvaney, Paul A; Nel, Andre E; Nordlander, Peter J; Parak, Wolfgang J; Penner, Reginald M; Rogach, Andrey L; Schaak, Raymond E; Stevens, Molly M; Wee, Andrew TS; Willson, C Grant; Fernandez, Laura E; Weiss, Paul S
Rapid crystallization of amorphous solid water by porosity induction (2022)

Rapid crystallization of amorphous solid water (ASW) is often associated with crystallization that initiates at random nucleation sites in the bulk and expands in all directions. In this work, by preparing sandwich films of acetonitrile (ACN) and ASW in the form of ACN@ASW and ASW@ACN in an ultrahigh vacuum (UHV), we demonstrate a new method for rapid crystallization of ASW <i>via</i> ACN diffusion-desorption induced porosity in the ASW matrix even in the window of 128-134 K, well below the normal crystallization temperature of 155 K. By placing an HDO (5% D<sub>2</sub>O in H<sub>2</sub>O) probe layer in ASW, we found that when ACN diffuses and desorbs through ASW, it induces ASW crystallization where the crystal grows both from the top and from the bottom simultaneously into the bulk. Crystallization kinetics and activation energy (<i>E</i><sub>a</sub>) for the formation of crystalline ice (CI) were evaluated using the Avrami equation and were compared with the previous reports. The evaluated <i>E</i><sub>a</sub> was ∼53 kJ mol<sup>-1</sup>, close to the <i>E</i><sub>a</sub> of crystal growth (47-56 kJ mol<sup>-1</sup>) and it suggested the absence of a nucleation process and supported rapid crystallization. Such occurrence of CI due to diffusion of ACN suggests a possible mechanism for the former's existence in many astrophysical environments.
Automated Method for Improving System Performance of Computer-Aided Diagnosis in Breast Ultrasound (2009)

The purpose of this research was to demonstrate the feasibility of a computerized auto-assessment method in which a computer-aided diagnosis (CADx) system itself provides a level of confidence for its estimate for the probability of malignancy for each radiologist-identified lesion. The computer performance was assessed within a leave-one-case-out protocol using a database of sonographic images from 542 patients (19% cancer prevalence). We investigated the potential of computer-derived confidence levels both as 1) an output aid to radiologists and 2) as an automated method to improve the computer classification performance-in the task of differentiating between cancerous and benign lesions for the entire database. For the former, the CADx classification performance was assessed within ranges of confidence levels. For the latter, the computer-derived confidence levels were used in the determination of the computer-estimated probability of malignancy for each actual lesion based on probabilities obtained from different views. The use of this auto-assessment method resulted in the modest but statistically significant increase in the area under the receiver operating characteristic (ROC) curve (AUC value) of 0.01 with respect to the performance obtained using the "traditional" CADx approach, increasing the AUC value from 0.89 to 0.90 ( p -value 0.03). We believe that computer-provided confidence levels may be helpful to radiologists who are using CADx output in diagnostic image interpretation as well as for automated improvement of the CADx classification for cancer.
Self-Calibrating Networks-On-Chip (2005)

Networks-on-chip provide an elegant framework to efficiently reuse predesigned cores. However, reuse of cores is jeopardized by new deep sub-micron noise effects that challenge the reliability of CMOS technology. Moreover, noise margins are further reduced as supply voltages scale down. We advocate that self-calibrating techniques will be needed to maintain an acceptable design trade-off between energy, performance, and reliability. As a result, self-calibrating techniques have to be integrated within networks-on-chip. This paper presents a self-calibrating link and discusses qualitatively the problem of controlling adaptively its voltage and frequency.
From Discrete Particles to Spherical Aggregates: A Simple Approach to the Self‐Assembly of Au Colloids (2005)

Here we demonstrate a simple, template-free approach to the formation of spherical gold aggregates through the reduction of HAuCl4 by NaBH4, in the presence of cysteine (Cys) as a capping agent. The resulting aggregates are quite stable in solution. The pH of the solution and the molar ratio of Au:Cys are two key empirical factors in the formation of such highly ordered aggregates. At slightly alkaline pH (7-10) and with Au:Cys ratios ranging from 1:0.5 to 1:2, spherical Au aggregates of 30-80 nm are formed. At lower Cys ratios (Au:Cys> or =1:0.5) very loosely linked aggregates are formed; however, at very high Cys ratios (Au:Cys< or =1:3), highly dispersed Au particles of 2-4 nm are obtained, which are virtually indistinguishable from the original colloidal form. Aggregate size is influenced markedly by component concentration; a 3-fold increase in standard levels resulted in Au spherical aggregates of a larger size, 200-500 nm. In addition, we used a combination of Cys and lysine (Lys) as a capping agent/cross-linker and found that the morphology of the Au colloid aggregates can be easily manipulated from a linear to a spherical form by adjusting the proportions of Cys and Lys in the capping agent/cross-linker mixture. The introduction of mercapto (SH)-containing organic acids reduced the cross-linking ability of Cys, especially in the case of long-chain acids. Complete disruption of the spherical aggregates highlights the importance of Cys per se. An explanation of this ordered self-assembly process is proposed, in the context of the known surface chemistry of Au colloids.
Denoising Of ECG Signal Using Mixed Windowing Technique (2018)

Electrocardiogram (ECG) is used for detection and diagnosis of various heart related diseases. ECG signal plays a vital role in monitoring the heart functions of the patients. There are several noises present in the ECG signal like muscle noise, PLI (Power line interference), contact noise etc. Most commonly the digital FIR filters are designed to reduce the noise. This paper deals with mixed windowing technique for designing a Digital FIR low pass filter. Mixed windowing technique is nothing but the combination of any two windowing techniques. The performance of the filter outputs based upon the SNR. Finally, the SNR of various mixed windowing techniques are compared with the SNR of individual windowing techniques .The whole work will be done in MATLAB Environment.