gebhart/patrepeval huggingface dataset:
633: A Multicenter, Randomized, Phase 3 Trial of a Novel Autologous Therapeutic Vaccine (VITESPEN) VS. Observation as Adjuvant Therapy in Patients at High Risk of Recurrence after Nephrectomy for Renal Cell Carcinoma (2007)

You have accessJournal of UrologyModerated Poster 18, Monday, May 21, 2007, 8:00 - 10:00 am1 Apr 2007633: A Multicenter, Randomized, Phase 3 Trial of a Novel Autologous Therapeutic Vaccine (VITESPEN) VS. Observation as Adjuvant Therapy in Patients at High Risk of Recurrence after Nephrectomy for Renal Cell Carcinoma Christopher G. Wood, Bernard Escudier, Louis Lacombe, Axel Hoos, Renu Gupta, Florentina Teofilovici, Robert C. Flanigan, Robert A. Figlin, and Pramod Srivastava Christopher G. WoodChristopher G. Wood More articles by this author , Bernard EscudierBernard Escudier More articles by this author , Louis LacombeLouis Lacombe More articles by this author , Axel HoosAxel Hoos More articles by this author , Renu GuptaRenu Gupta More articles by this author , Florentina TeofiloviciFlorentina Teofilovici More articles by this author , Robert C. FlaniganRobert C. Flanigan More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , and Pramod SrivastavaPramod Srivastava More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30873-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "633: A Multicenter, Randomized, Phase 3 Trial of a Novel Autologous Therapeutic Vaccine (VITESPEN) VS. Observation as Adjuvant Therapy in Patients at High Risk of Recurrence after Nephrectomy for Renal Cell Carcinoma." The Journal of Urology, 177(4S), p. 212 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 212 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Christopher G. Wood More articles by this author Bernard Escudier More articles by this author Louis Lacombe More articles by this author Axel Hoos More articles by this author Renu Gupta More articles by this author Florentina Teofilovici More articles by this author Robert C. Flanigan More articles by this author Robert A. Figlin More articles by this author Pramod Srivastava More articles by this author Expand All Advertisement PDF downloadLoading ...
Immuno‐MALDI‐TOF MS: New perspectives for clinical applications of mass spectrometry (2009)

The discovery of novel biomarkers by means of advanced detection tools based on proteomic analysis technologies necessitates the development of improved diagnostic methods for application in clinical routine. On the basis of three different application examples, this review presents the limitations of conventional routine diagnostic assays and illustrates the advantages of immunoaffinity enrichment combined with MALDI-TOF MS. Applying this approach increases the specificity of the analysis supporting a better diagnostic recognition, sensitivity, and differentiation of certain diseases. The use of MALDI-TOF MS as detection method facilitates the identification of modified peptides and proteins providing additional information. Further, employing respective internal standard peptides allows for relative and absolute quantitation which is mandatory in the clinical context. Although MALDI-TOF MS is not yet established for clinical routine diagnostics this technology has a high potential for improvement of clinical diagnostics and monitoring therapeutic efficacy.
Synthesis, characterization, and field-effect transistor performance of poly[2,6-bis(3-tridecanoxythiophen-2-yl)benzo[1,2-b;4,5-b′]dithiophene] Part A Polymer chemistry (2010)

A new copolymer of benzo[1,2-b:4,5-b′]dithiophene and 3,3′-bis(tridecanoxy)-5,5′-bithiophene was synthesized through Stille copolymerization. The bis-(3-alkoxythiophene) monomer was synthesized through a silver fluoride mediated, palladium-catalyzed cross-coupling, in which bromide functional groups were preserved instead of consumed. The copolymer has been characterized and applied in field-effect transistors, giving a hole mobility of 2 x 10⁻³ cm²/Vs and an on/off ratio >10⁶, with negligible hysteresis, on standard silicon substrates.
Enhanced and stabilized photoluminescence of perovskite cesium lead bromide nanocubes through ordered assemblies (2023)

The quantum yield of photoluminescence and the photostability of perovskite cesium lead bromide nanocubes were improved by the formation of two-dimensional ordered arrays on a substrate.
Source Selection in Transfer Learning for Improved Service Performance Predictions (2021)

Learning performance models for network and cloud services is challenging due to the dynamics of the operational environment stemming from network changes, and scaling and migration decisions in the cloud. This requires exchange or adaptation of the models in order to maintain prediction accuracy over time. Approaches that incorporate previously acquired knowledge using transfer learning is a viable technique for timely and robust model adaptation, especially when the training data is limited. In this paper, we study the challenge of source selection in transfer learning for improved service performance prediction. We quantify the impact of different source domains on the accuracy of a target model in another domain. The evaluation is performed using data traces obtained from a testbed that runs a Video-on-Demand service and a Key-Value Store under various load conditions. We find that the choice of source domain can yield a transfer gain, and sometimes a substantial transfer penalty. To mitigate this, we propose and evaluate two source-selection approaches with the aim of selecting a source domain with relevant knowledge for the target domain. A key result is that such source selection should encourage source-domain diversity rather than domain similarity in scenarios with few samples in the target domain.
Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens (1983)

Five nonoverlapping antigenic sites (sites I through V) of woodchuck hepatitis virus surface antigen were identified with competitive binding assays involving monoclonal antibodies. Site I contributed to cross-reactions among surface antigens of hepatitis B-like viruses infecting woodchucks, ground squirrels, and humans. At least three distinct sites (sites I, II, and III) are responsible for cross-reactions between woodchuck and ground squirrel hepatitis virus surface antigens. Sites IV and V of woodchuck hepatitis virus surface antigen are not major cross-reactive sites, suggesting that these elicit virus-specific antibodies. There were no cross-reactions with duck hepatitis B virus surface antigen.
Inhibition of A9 and A10 dopamine cells by the cholecystokinin‐B antagonist LY262691: Mediation through feedback pathways from forebrain sites (1993)

The diphenylpyrazolidinone cholecystokinin-B (CCK-B) antagonist LY262691 has been shown to decrease the number of spontaneously active dopamine (DA) cells in the ventral tegmental area (A10) and substantia nigra (A9) of the anesthetized rat. In the present study, we examined the localization of the receptors mediating these effects of LY262691 on A9 and A10 DA cells. In one group of anesthetized rats, the effects of systemic administration of LY262691 on the number of spontaneously active A9 or A10 DA cells was determined using extracellular, single-unit recordings after radio frequency lesions were placed in the nucleus accumbens, caudate-putamen, or medial prefrontal cortex. Lesions of the caudate-putamen blocked the effects of systemically administered LY262691 on the number of spontaneously active A9, but not A10, DA cells. Conversely, lesions of the n. accumbens blocked the effects of systemically administered LY262691 on A10, but not A9, DA cells. Lesions of the medial prefrontal cortex blocked the effects of systemically administered LY262691 on both A9 and A10 DA cells. In a separate group of anesthetized rats, the number of spontaneously active A9 or A10 DA cells was determined after LY262691 was microinjected into the n. accumbens, caudate-putamen, or medial prefrontal cortex. Microinjection of LY262691 into the caudate-putamen led to a significant decrease in the number of spontaneously active A9, but not A10, DA cells. Conversely, microinjection of LY262691 into the n. accumbens or medial prefrontal cortex led to a significant decrease in the number of spontaneously active A10, but not A9, DA cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Evidence for Local Eosinophil Differentiation Within Allergic Nasal Mucosa: Inhibition with Soluble IL-5 Receptor (2000)

Eosinophil differentiation occurs within the bone marrow in response to eosinopoietic cytokines, particularly IL-5. Recently, however, eosinophil precursors (CD34/IL-5Ralpha+ cells) and IL-5 mRNA+ cells have been identified within the lungs of asthmatics, indicating that a population of eosinophils may differentiate in situ. In this report, we examined the presence of eosinophil precursors within allergic nasal mucosa and examined whether they undergo local differentiation following ex vivo stimulation. We cultured human nasal mucosa obtained from individuals with seasonal allergic rhinitis with either specific allergen, recombinant human IL-5 (rhIL-5), or allergen + soluble IL-5Ralpha (sIL-5Ralpha), shown to antagonize IL-5 function. Simultaneous immunocytochemistry and in situ hybridization demonstrated that there were fewer cells coexpressing CD34 immunoreactivity and IL-5Ralpha mRNA following culture with allergen or rhIL-5, compared with medium alone. Immunostaining revealed that the number of major basic protein (MBP) immunoreactive cells (eosinophils) was higher within tissue stimulated with allergen or rhIL-5, compared with unstimulated tissue. In situ hybridization detected an increase in IL-5 mRNA+ cells in sections from tissue cultured with allergen, compared with medium alone. These effects were not observed in tissue cultured with a combination of allergen and sIL-5Ralpha. Colocalization analysis indicated this expression to be mainly, but not exclusively, T cell (44%) and eosinophil (10%) derived. Our findings suggest that a subset of eosinophils may differentiate locally within allergic nasal mucosa, in what appears to be a highly IL-5-dependent fashion, and imply that this process might be regulated in vivo by endogenous production of sIL-5Ralpha.
Surface Modification and Electrochemical Metallization of Advanced Polymers for Energy Application (2015)

Combination of polymeric and metallic layers in a single device is becoming inevitable for applications in an increasing number of fields, including alternative energy. A basic product consisting in a metal-polymer (partially fluorinated) bilayer can be simply obtained by two steps. The first step of the process consists in surface modification of the polymer by plasma treatment, whose main effect is to increase the wettability. The increase of wettability by water is crucial for the second step of the process, which consists in aqueous based electroless deposition of metals. As revealed by cross cut and bending tests, adhesion between the metallic and polymeric layer is excellent. Given the suitable transparency and weathering resistance of Halar ® ECTFE, the application of this process for production of solar concentrator mirrors is being considered. Light reflection properties and UV ageing were determined for this purpose.
Engineering an [FeFe]-Hydrogenase: Do Accessory Clusters Influence O2 Resistance and Catalytic Bias? (2018)

[FeFe]-hydrogenases, HydAs, are unique biocatalysts for proton reduction to H<sub>2</sub>. However, they suffer from a number of drawbacks for biotechnological applications: size, number and diversity of metal cofactors, oxygen sensitivity. Here we show that HydA from Megasphaera elsdenii (MeHydA) displays significant resistance to O<sub>2</sub>. Furthermore, we produced a shorter version of this enzyme (MeH-HydA), lacking the N-terminal domain harboring the accessory FeS clusters. As shown by detailed spectroscopic and biochemical characterization, MeH-HydA displays the following interesting properties. First, a functional active site can be assembled in MeH-HydA in vitro, providing the enzyme with excellent hydrogenase activity. Second, the resistance of MeHydA to O<sub>2</sub> is conserved in MeH-HydA. Third, MeH-HydA is more biased toward proton reduction than MeHydA, as the result of the truncation changing the rate limiting steps in catalysis. This work shows that it is possible to engineer HydA to generate an active hydrogenase that combines the resistance of the most resistant HydAs and the simplicity of algal HydAs, containing only the H-cluster.
Molecular Characterization and Clinical Outcomes of Primary Gleason Pattern 5 Prostate Cancer After Radical Prostatectomy (2019)

Potentially actionable homologous recombination and mismatch repair alterations are observed in a significant proportion of patients with very high-risk PC at the time of radical prostatectomy. These findings could inform the design of prospective trials in this patient population.
Supplementary Table 3-8 from Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis (2023)

&lt;p&gt;Supplementary Table 3-8&lt;/p&gt;
Targeted Maximum Likelihood Based Causal Inference: Part I (2010)

Given causal graph assumptions, intervention-specific counterfactual distributions of the data can be defined by the so called G-computation formula, which is obtained by carrying out these interventions on the likelihood of the data factorized according to the causal graph. The obtained G-computation formula represents the counterfactual distribution the data would have had if this intervention would have been enforced on the system generating the data. A causal effect of interest can now be defined as some difference between these counterfactual distributions indexed by different interventions. For example, the interventions can represent static treatment regimens or individualized treatment rules that assign treatment in response to time-dependent covariates, and the causal effects could be defined in terms of features of the mean of the treatment-regimen specific counterfactual outcome of interest as a function of the corresponding treatment regimens. Such features could be defined nonparametrically in terms of so called (nonparametric) marginal structural models for static or individualized treatment rules, whose parameters can be thought of as (smooth) summary measures of differences between the treatment regimen specific counterfactual distributions.In this article, we develop a particular targeted maximum likelihood estimator of causal effects of multiple time point interventions. This involves the use of loss-based super-learning to obtain an initial estimate of the unknown factors of the G-computation formula, and subsequently, applying a target-parameter specific optimal fluctuation function (least favorable parametric submodel) to each estimated factor, estimating the fluctuation parameter(s) with maximum likelihood estimation, and iterating this updating step of the initial factor till convergence. This iterative targeted maximum likelihood updating step makes the resulting estimator of the causal effect double robust in the sense that it is consistent if either the initial estimator is consistent, or the estimator of the optimal fluctuation function is consistent. The optimal fluctuation function is correctly specified if the conditional distributions of the nodes in the causal graph one intervenes upon are correctly specified. The latter conditional distributions often comprise the so called treatment and censoring mechanism. Selection among different targeted maximum likelihood estimators (e.g., indexed by different initial estimators) can be based on loss-based cross-validation such as likelihood based cross-validation or cross-validation based on another appropriate loss function for the distribution of the data. Some specific loss functions are mentioned in this article.Subsequently, a variety of interesting observations about this targeted maximum likelihood estimation procedure are made. This article provides the basis for the subsequent companion Part II-article in which concrete demonstrations for the implementation of the targeted MLE in complex causal effect estimation problems are provided.
Simplified Single Channel High-Speed Polarization Sensitive Retinal SDOCT (2008)

Polarization sensitive OCT (PSOCT) provides additional contrast for retinal imaging. We have constructed and tested a compact, single channel and single camera, high-speed (17,000 A-scans/sec) polarization sensitive SDOCT (PS-SDOCT) system for retinal imaging.
Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting (2017)

Blast-related traumatic brain injury (TBI) is a signature injury of recent military conflicts, leading to increased Department of Defense (DoD) interest in its potential long-term effects, such as chronic traumatic encephalopathy (CTE). The DoD Blast Injury Research Program Coordinating Office convened the 2015 International State-of-the-Science Meeting to discuss the existing evidence regarding a causal relationship between TBI and CTE. Over the course of the meeting, experts across government, academia, and the sports community presented cutting edge research on the unique pathological characteristics of blast-related TBI, blast-related neurodegenerative mechanisms, risk factors for CTE, potential biomarkers for CTE, and treatment strategies for chronic neurodegeneration. The current paper summarizes these presentations. Although many advances have been made to address these topics, more research is needed to establish the existence of links between the long-term effects of single or multiple blast-related TBI and CTE.
Fungal Cellulases (2015)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFungal CellulasesChristina M. Payne†#, Brandon C. Knott‡#, Heather B. Mayes§#, Henrik Hansson⊥, Michael E. Himmel∥, Mats Sandgren⊥, Jerry Ståhlberg⊥, and Gregg T. Beckham*‡View Author Information† Department of Chemical and Materials Engineering and Center for Computational Sciences, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky 40506, United States‡ National Bioenergy Center, National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401, United States§ Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States∥ Biosciences Center, National Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401, United States⊥ Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences, Uppsala BioCenter, Almas allé 5, SE-75651 Uppsala, Sweden*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 3, 1308–1448Publication Date (Web):January 28, 2015Publication History Received2 July 2014Published online28 January 2015Published inissue 11 February 2015https://doi.org/10.1021/cr500351cCopyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views32767Altmetric-Citations547LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (94 MB) Get e-AlertsSUBJECTS:Carbohydrates,Cellulose,Chemical structure,Genetics,Peptides and proteins Get e-Alerts
Supplementary Figure 2 from Cyclooxygenase-2 Inhibition Suppresses α<sub>v</sub>β<sub>6</sub> Integrin–Dependent Oral Squamous Carcinoma Invasion (2023)

Supplementary Figure 2 from Cyclooxygenase-2 Inhibition Suppresses α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; Integrin–Dependent Oral Squamous Carcinoma Invasion
A novel human disease with abnormal prion protein sensitive to protease (2008)

The distinct histopathological, PrP immunohistochemical, and physicochemical features, together with the homogeneous genotype, indicate that this is a previously unidentified type of disease involving the PrP, which we designated "protease-sensitive prionopathy" (or PSPr). Protease-sensitive prionopathy is not rare among prion diseases, and it may be even more prevalent than our data indicate because protease-sensitive prionopathy cases are likely also to be classified within the group of non-Alzheimer's dementias.
Multisize CdSe Nanocrystal/Polymer Nanocomposites for Selective Vapor Detection Identified from High-Throughput Screening Experimentation (2012)

We have implemented high-throughput spectroscopic screening tools for the investigation of vapor-selectivity of CdSe semiconductor nanocrystals of different size (2.8- and 5.6-nm diameter) upon their incorporation in a library of rationally selected polymeric matrices. This library of resulting sensing materials was exposed to polar and nonpolar vapors in air. Each of the sensing materials demonstrated its own photoluminescence vapor-response patterns. Two criteria for the evaluation of vapor responses of the library of sensing materials included the diversity and the magnitude of sensing responses. We have found several polymer matrices that simultaneously meet these criteria. Our new sensing materials based on polymer-embedded semiconductor nanocrystal reagents of different size promise to overcome photobleaching and short shelf life limitations of traditional fluorescent organic reagent-based sensing materials.
Temperature Insensitive Refractometer Using Core and Cladding Modes in Open-Top Ridge Waveguide (2008)

In order to overcome the well-known limitation of temperature instability in Bragg grating waveguide sensors, a temperature insensitive open-top ridge waveguide refractometer is developed by using a cladding mode resonance as a temperature reference. The relative shift of the core mode resonance to cladding mode resonance is used to measure the refractive index of substances under test. Specifically, the device fabricated here produces a relative resonance shift of 1 pm for every 5 times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> of measured index change, with a temperature sensitivity ~ 0.5 pm/degC.
Supplementary Figure 1 from The ERBB4/HER4 Intracellular Domain 4ICD Is a BH3-Only Protein Promoting Apoptosis of Breast Cancer Cells (2023)

Supplementary Figure 1 from The ERBB4/HER4 Intracellular Domain 4ICD Is a BH3-Only Protein Promoting Apoptosis of Breast Cancer Cells