gebhart/patrepeval huggingface dataset:
Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women (1992)

n this study, total body fat content and fat topography were related to glucose metabolism in the basal and insulin-stimulated states in 18 nonobese and 18 obese premenopausal nondiabetic women. All subjects received a euglycemic insulin (20 mU.min-1.m2) clamp study in combination with [3-3H]-D-glucose infusion and indirect calorimetry to quantitate total body glucose uptake, glucose oxidation, and nonoxidative glucose disposal. Total body fat content was determined with tritiated water, whereas body fat distribution was estimated from the WHR, the STR, and the VSR (measured by magnetic resonance imaging). In the postabsorptive state, total body glucose utilization, glucose oxidation, and nonoxidative glucose disposal rates were similar in nonobese and obese women, whereas during the insulin clamp all three metabolic parameters were reduced significantly in the obese group. In nonobese women, total body fat content was related inversely to both total and nonoxidative glucose disposal during the insulin clamp, whereas no relationship was found between glucose metabolism (total, oxidative, and nonoxidative) and WHR, STR, or VSR. In contrast, in obese women, no relationship was observed between total body fat content and any measure of insulin-mediated glucose metabolism. However, both WHR and VSR were related inversely to total, oxidative, and nonoxidative glucose disposal rates during the insulin clamp. These results suggest that total body fat content and body fat topography are associated differently with insulin-mediated glucose metabolism in nonobese and obese women. In the nonobese women, total body fat mass appears to be a primary determinant of tissue sensitivity to insulin, whereas in obese women, body fat topography exerts a more dominant effect.
What is the Role of Serological Testing Between Stages of Two-stage Reconstruction of the Infected Prosthetic Knee? (2010)

Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
Prevalence and Prognosis of Unrecognized Myocardial Infarction in Asymptomatic Patients With Diabetes: A Two-Center Study With Up to 5 Years of Follow-up (2019)

Unrecognized MI is prevalent in asymptomatic patients with diabetes without a history of cardiac disease and confers a markedly increased risk of death and clinical MI.
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses (2017)

The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are paroxysmal nocturnal haemoglobinuria and atypical haemolytic uremic syndrome, but many other diseases are candidates for complement inhibition. It has been postulated that eculizumab does not inhibit C5a formation in vivo, in contrast to what would be expected since it blocks C5 cleavage. We recently revealed that this finding was due to a false positive reaction in a C5a assay. In the present study, we identified expression of a neoepitope which was exposed on C5 after binding to eculizumab in vivo. By size exclusion chromatography of patient serum obtained before and after infusion of eculizumab, we document that the neoepitope was exposed in the fractions containing the eculizumab-C5 complexes, being positive in this actual C5a assay and negative in others. Furthermore, we confirmed that it was the eculizumab-C5 complexes that were detected in the C5a assay by adding an anti-IgG4 antibody as detection antibody. Competitive inhibition by anti-C5 antibodies localized the epitope to the C5a moiety of C5. Finally, acidification of C5, known to alter C5 conformation, induced a neoepitope reacting identical to the one we explored, in the C5a assays. These data are important for interpretation of complement analyses in patients treated with eculizumab.
Photolithographically fabricated low-loss asymmetric silicon slot waveguides (2011)

We demonstrate low-loss asymmetric slot waveguides in silicon-on-insulator (SOI). 130 and 180 nm wide slots were fabricated with a 248 nm stepper, in 200 nm thick silicon. An asymmetric waveguide design is shown to expand the range in which the TE0 mode is guided and suppress the TE1 mode, while still maintaining a sharp concentration of electric field in the center of the slot. Optical propagation losses of 2 dB/cm or less are shown for asymmetric slot waveguides with 130 nm wide slots and 320 and 100 nm wide arms.
Effect of Mesenchymal Stem Cells Associated to Matrixen on the Erectile Function in the Rat Model with Bilateral Cavernous Nerve Crushing Injury (2012)

The erectile function was more preserved in MSCs/Matrixen group compared with the administration of MSCs alone in the rats with bilateral cavernous nerve crushing injury. Therefore, we consider that the use of transplant cell carrier such as Matrixen may help the implantation of MSCs and improve the therapeutic effect of MSCs.
Constitutively Elevated Levels of Putrescine and Putrescine-Generating Enzymes Correlated with Oxidant Stress Resistance in Conyza bonariensis and Wheat (1997)

Oxidant stress resistance in Conyza bonariensis and wheat (Triticum aestivum) has been correlated with high levels of antioxidant enzyme activities. Additionally, external oxidant stresses can increase a plant's levels of the enzymes of polyamine biosynthesis and polyamines, especially putrescine. We investigated the constitutive relationships between putrescine, putrescine-generating enzymes, and oxidant stress resistance in wheat and C. bonariensis. Putrescine was Constitutively elevated (2.5- to 5.7-fold) in 2-week-old-resistant wheat and C. bonariensis biotypes, which correlated with a 10- to 15-fold increase in paraquat oxidant resistance. Arginine and ornithine decarboxylase activities doubled, along with higher putrescine levels in resistant C. bonariensis. The variations in levels of putrescine and arginine and ornithine decarboxylase activities paralleled the constitutive variation of antioxidant enzymes, as well as oxidant resistance. Higher levels of both putrescine and antioxidant enzyme activities occurred during a peak of oxidant resistance at 10 weeks, when paraquat resistance in C. bonariensis plants is >50-fold greater than in the sensitive biotype. Application of 100 [mu]M putrescine can double oxidant-stress resistance in the resistant C. bonariensis. Putrescine may play an important role in contributing to the base level of oxidant resistance found at the nonpeak period.
Supplementary Table 1 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy (2023)

&lt;p&gt;PDF file - 23K, Quantitative determination of the binding affinities of the parent and modified STAT3 decoys&lt;/p&gt;
Proceedings of Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP 2008), Cannes, France, April 9-11 (2008)

ISBN : 978-2-3550-0006-5
Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice (2018)

Acoustic trauma can induce temporary or permanent noise-induced hearing loss (NIHL). Noise exposed animal models allow us to study the effects of various noise trauma insults on the cochlea and auditory pathways. Here we studied the short-term and long-term functional changes occurring in the auditory system following exposure to two different noise traumas. Several measures of hearing function known to change following noise exposure were examined: Temporary (TTS) and permanent (PTS) threshold shifts were measured using auditory brainstem responses (ABR), outer hair cell function was examined using distortion product otoacoustic emissions (DPOAEs), and auditory temporal processing was assessed using a gap-in-noise (GIN) ABR paradigm. Physiological measures were made before and after the exposure (24 hours, 2 weeks, 4 weeks, and 1 year). The animals were perfused and their brain, and cochlea were collected for future biomarker studies. Young adult mice were exposed to 110 dB and 116 dB octave-band noise levels for 45 minutes, and both groups demonstrated significant threshold shifts 1 day post-noise exposure across all frequencies. However 2 weeks postexposure, PTS within the 110 dB group was significantly reduced compared to 1 day post trauma, this improvement in thresholds was not as great in the 116 dB exposure group. At 2 weeks post-trauma, differences between the measured PTS in the two groups was significant for 4 of the 7 measured frequencies. At this 1 year time point after exposure, mice in the 110 dB group showed very minor PTS, but the 116 dB group showed a large PTS comparable to their 2 and 4 week PTS. At this time point, PTS variation between the two groups was significant across all frequencies. DPOAE amplitudes measured 2 weeks post exposure showed recovery for all frequencies within 10 dB (average) of the baseline in the 110 dB group, however for the 116 dB exposure DP amplitudes were elevated by about 30 dB. The differences in DPOAE amplitudes between the 110 dB and 116 dB groups were significant at 2 weeks, 4 weeks, and 1 year post-trauma in the mid frequency range. At 2 weeks, 4 weeks, and 1 year, DPOAE thresholds returned to within 10 dB of the baseline for the 110 dB group in the low and mid frequency range, whereas the 116 dB group still showed shifts of 30 dB for all frequency ranges. For Gap ABRs, there was a significant decrease in both noise burst 1 (NB1) and noise burst 2 (NB2) amplitudes for peaks 1 and 4 in the 116 dB group relative to the 110 dB group when measured at 1 year post trauma. These results indicate that a 6 dB increase in noise exposure intensity results in a significant increased ototrauma in both the peripheral and central auditory systems.
Image formation in coronagraphs due to mirror polarization aberrations (2017)

The PSF for astronomical telescopes and instruments depends not only on geometric wavefront aberrations, but also on those polarization aberrations from the polarization properties of reflecting and transmitting surfaces. The image plane irradiance distribution is the linear superposition of four PSF images: one for each of the two orthogonal polarizations and one for each of two cross-coupled polarization terms.
Dynamic Analysis of Existing Tarbela Intake Towers (1986)

According to general practice at the time of the design, the pseudostatic method of applying earthquake loading was used. The basic acceleration was 0. 1g. A post-construction seismological study was made and peak accelerations ranging from 0. 35g to 0. 65g were adopted for the dynamic reanalysis of the main project structures. Elastic linear frame analyses using a Design Basis Earthquake indicated possible significant damage to the power intake towers. An improved dynamic response could be obtained by removing the steel tower, concrete shroud and hemispherical bulkhead with its hoisting machinery; all features no longer functionally necessary. The work has been approved for construction and will be done in the dry season when the pool level is low, with very little consequent loss of power.
High-speed wide band board-to-board optical interconnection (1991)

Increases in modulation speed and interconnection distance have driven electrical interconnects to their theoretical limits, beyond which optical interconnections are the only possible alternative. In this paper, we report, we believe for the first time, a 14-GHz board-to-board optical interconnection. The optical data bus boards were constructed by depositing a graded-index (GRIN) polymer film on tope of a substrate. Thanks to the GRIN characteristic of the polymer film, an array of high-index substrates can be employed as the optical data bus boards. The propagation loss of the optical data bus was measured by the two prism method. We routinely achieved ~0.5 dB/cm propagation loss on various substrates. Board to board optical interconnection was achieved using a microprism array as small as 100 µm with a coupling bandwidth larger than 800 nm, which is two orders of magnitude larger than the 3-D optical interconnects based on holographic optical elements. A 1-GHz baseband signal was provided using an external modulator. Finally, the high-speed signal was detected by integrating a photodetector at the end face of the output microprism.
Loss of planktotrophy and speciation: geographical fragmentation in the deep-water gastropod genusBathytoma(Gastropoda, Conoidea) in the western Pacific (2010)

Dispersal capabilities are crucial in how speciation patterns are determined in marine invertebrates. Species possessing a long-living planktonic larva apparently have a dispersal advantage over those with non-planktotrophic development, and their distant populations may exchange genetic material, maintaining a broad geographical range for the species. Recent species of the gastropod genus Bathytoma (Conoidea) are all characterized by non-planktotrophic development, having most probably lost a free-swimming larva in the pre-Pliocene, as Miocene fossils have protoconchs indicating planktotrophic larval development. All have a bathyal distribution (100–1500 m), which implies that their capability for direct expansion on the bottom is restricted by both deep-sea basins and shallow-water areas, especially in insular West and South-West Indo-Pacific. Therefore, it can be hypothesized that Bathytoma populations should represent numerous, mostly allopatric taxa restricted to a single or contiguous island groups. We tested this hypothesis using molecular and morphological characters independently. One hundred and thirty-eight specimens from the Philippines, Solomons, Vanuatu, and the Coral Sea were sequenced for one mitochondrial (COI) and one nuclear (ITS2) gene, and 14 operational molecular units were recognized. When these molecular units are overlaid over shell characters, 13 species (11 unnamed) and one form of uncertain status are recognized: three occur in the Philippines, six in the Solomons and one in New Caledonia. Broad distributions (inter-archipelagic) are uncommon (three species). On the whole, the phylogeographic pattern of the diversity in the genus is rather complex and probably also reflects processes of sympatric and fine-scale allopatric speciation, and local extinctions. The eleven new species are described and named.
rRNA transcription is integral to liquid-liquid phase separation and maintenance of nucleolar structure (2022)

Summary Beginning with transcription of ribosomal RNA (rRNA) by RNA Polymerase (Pol) I in the nucleolus, ribosome biogenesis is intimately tied to cell growth and proliferation. Perturbation of ribosome biogenesis has been previously shown to affect nucleolar structure, yet the underlying mechanism is unknown. We generated loss-of-function mouse mutants of Pol I subunits, Polr1a, Polr1b, Polr1c and Polr1d , thereby genetically inhibiting rRNA transcription and ribosome biogenesis. Pol I mutant embryos are preimplantation lethal and have fewer nucleoli. Using hiPSCs triple labeled for the three nucleolar compartments, we observe two phenotypes upon Pol I inhibition: a single condensed nucleolus, and fragmented nucleoli. We find that when rRNA transcription is inhibited, the viscosity of the granular compartment of the nucleolus is increased disrupting its liquid-liquid phase separation properties, which results in a condensed nucleolus. Taken together, our data suggests that Pol I function and rRNA transcription are required for maintaining nucleolar structure and integrity.
BGP attribute for North-Bound Distribution of Traffic Engineering (TE) performance Metrics (2013)

In order to populate network performance information like link
latency, latency variation, packet loss and bandwidth into Traffic
Engineering Database(TED) and ALTO server, this document describes
extensions to BGP protocol, that can be used to distribute network
performance information (such as link delay, delay variation, packet
loss, residual bandwidth, available bandwidth and utilized bandwidth
).
One-Flow, Multi-Step Synthesis of Nucleosides via Brønsted Acid- Catalyzed Glycosylation (2011)

Nucleosides in flow: A general, scalable method of Brønsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Brønsted acids, particularly pyridinium triflates, can be used. A one-flow multistep synthesis of unprotected nucleosides is also reported (see scheme).
Hydride Ion as Photoelectron Donor in Microporous Crystal (2005)

Atomic hydrogen (H0) and trapped electrons generated by UV illumination (lambda approximately 330 nm) at 4 K were observed using electron paramagnetic resonance (EPR) in a 12CaO.7Al2O3 (C12A7) crystal heated in a hydrogen atmosphere. The concentration ratio of generated H0 to the electrons encaged in the subnanometer-sized cages of C12A7 (F+ centers) is almost 1:1, providing direct evidence that a hydride ion, H-, accommodated in the cage by the heat treatment was dissociated to a pair of an H0 and an electron by a UV photon: H- --> H0 + e- (F+). After annealing at 300 K, H0 was completely annihilated, while approximately 60% of the trapped electrons survived. The remaining electrons can hop between neighboring cages and give electrical conductivity to C12A7. The hyperfine splitting of the EPR spectrum of H0 in C12A7 (48.6 mT) is 4% smaller than that of the neutral hydrogen atom (50.6 mT), implying that H0 is trapped at the interstitial sites among the cages.
WILDTRACK: A Multi-camera HD Dataset for Dense Unscripted Pedestrian Detection (2018)

People detection methods are highly sensitive to occlusions between pedestrians, which are extremely frequent in many situations where cameras have to be mounted at a limited height. The reduction of camera prices allows for the generalization of static multi-camera set-ups. Using joint visual information from multiple synchronized cameras gives the opportunity to improve detection performance. In this paper, we present a new large-scale and high-resolution dataset. It has been captured with seven static cameras in a public open area, and unscripted dense groups of pedestrians standing and walking. Together with the camera frames, we provide an accurate joint (extrinsic and intrinsic) calibration, as well as 7 series of 400 annotated frames for detection at a rate of 2 frames per second. This results in over 40 000 bounding boxes delimiting every person present in the area of interest, for a total of more than 300 individuals. We provide a series of benchmark results using baseline algorithms published over the recent months for multi-view detection with deep neural networks, and trajectory estimation using a non-Markovian model.
HACCLE: Metaprogramming for Secure Multi-Party Computation -- Extended Version (2020)

Cryptographic techniques have the potential to enable distrusting parties to collaborate in fundamentally new ways, but their practical implementation poses numerous challenges. An important class of such cryptographic techniques is known as Secure Multi-Party Computation (MPC). Developing Secure MPC applications in realistic scenarios requires extensive knowledge spanning multiple areas of cryptography and systems. And while the steps to arrive at a solution for a particular application are often straightforward, it remains difficult to make the implementation efficient, and tedious to apply those same steps to a slightly different application from scratch. Hence, it is an important problem to design platforms for implementing Secure MPC applications with minimum effort and using techniques accessible to non-experts in cryptography. In this paper, we present the HACCLE (High Assurance Compositional Cryptography: Languages and Environments) toolchain, specifically targeted to MPC applications. HACCLE contains an embedded domain-specific language Harpoon, for software developers without cryptographic expertise to write MPC-based programs, and uses Lightweight Modular Staging (LMS) for code generation. Harpoon programs are compiled into acyclic circuits represented in HACCLE's Intermediate Representation (HIR) that serves as an abstraction over different cryptographic protocols such as secret sharing, homomorphic encryption, or garbled circuits. Implementations of different cryptographic protocols serve as different backends of our toolchain. The extensible design of HIR allows cryptographic experts to plug in new primitives and protocols to realize computation. And the use of standard metaprogramming techniques lowers the development effort significantly.
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer (2021)

Androgen receptor (AR) transcriptional reactivation plays a key role in the development and progression of lethal castration-resistant prostate cancer (CRPC). Recurrent alterations in the AR enable persistent AR pathway signaling and drive resistance to the treatment of second-generation antiandrogens. AR F877L, a point mutation in the ligand binding domain of the AR, was identified in patients who acquired resistance to enzalutamide or apalutamide. In parallel to our previous structure-activity relationship (SAR) studies of compound <b>4</b> (JNJ-pan-AR) and clinical stage compound <b>5</b> (JNJ-63576253), we discovered additional AR antagonists that provide opportunities for future development. Here we report a highly potent series of spirocyclic thiohydantoins as AR antagonists for the treatment of the F877L mutant and wild-type CRPC.
The Angiotensin II Type 1 Receptor Mediates Renal Interstitial Content of Tumor Necrosis Factor-α in Diabetic Rats (2003)

A unique microdialysis technique was used to demonstrate that increased levels of angiotensin II (Ang II) and consequent stimulation of the Ang II type 1 (AT(1)) receptor increase the renal content of TNF-alpha in diabetes. Recovery of Ang II and TNF-alpha in renal interstitial fluid (RIF) was measured in conscious rats before and weekly for 12 wk after induction of diabetes with streptozocin and in response to oral valsartan (10 mg/kg.d). Recovery of Ang II in RIF was significantly higher in diabetic rats than in nondiabetic rats. In diabetic rats, RIF recovery of TNF-alpha increased by approximately 67% over baseline, whereas it was unchanged in nondiabetic rats. AT(1) receptor blockade with valsartan prevented the increase in TNF-alpha in the diabetic group. This study shows that diabetes is associated with an increase in the vasoconstrictive hormone Ang II and the inflammatory cytokine TNF-alpha, both of which play a role in accelerating renal function decline in diabetic nephropathy. The study also confirms that valsartan reduces intrarenal level of TNF-alpha by acting on Ang II at the AT(1) receptor level. This finding of a potential antiinflammatory effect for valsartan is new and in addition to its known antihypertensive effects.