gebhart/patrepeval huggingface dataset:
Effect of Adalimumab Induction Therapy on Clinical Laboratory Parameters Suggesting Improved Nutrition and Inflammation Status in Patients with Moderately to Severely Active Ulcerative Colitis (2010)

Purpose: To describe the evolution of clinical laboratory indicators of nutritional status and inflammation in patients with moderately to severely active ulcerative colitis (UC) enrolled in a large randomized, placebo-controlled study of adalimumab for induction of remission. Methods: Adult patients with moderately to severely active UC, failing treatment with corticosteroids and/or immunosuppressants, were enrolled and randomized to receive subcutaneous ADA160/80 (160 mg at Week 0, 80 mg at Week 2, 40 mg at Weeks 4 and 6), ADA80/40 (80 mg at Week 0, 40 mg at Weeks 2, 4, and 6) or placebo. Dosing of concomitant corticosteroids and/or immunosuppressants were maintained stable during the 8-week study. Mean changes from baseline in hemoglobin, hematocrit, red cell count, total protein, albumin, and median changes from baseline in C-reactive protein (CRP), were assessed at intervals in the safety population (all patients who received at least 1 dose of study drug). Analyses were performed on observed cases; comparisons between the ADA groups and the placebo group were made using 1-way analysis of variance (mean changes) or the Kruskal-Wallis test (median changes). Results: In the safety population, 521 of 576 patients completed 8 weeks (placebo, n=204/223; ADA80/40, n=118/130; ADA160/80, n=199/223). Changes from baseline at Week 8 are shown in the table. ADA160/80 treatment was associated with statistically significant changes from baseline in the clinical laboratory parameters shown, compared with placebo treatment. Conclusion: In this study, adalimumab therapy for 8 weeks was associated with statistically and clinically significant improvements in several nutritional indicators and direct and indirect markers of inflammation, compared with placebo treatment. Disclosure: Dr Reinisch - Consultant: Abbott Dr Sandborn - Consultant, research funding: Abbott Dr Hommes - Consultant, research funding: Abbott Dr Thakkar - Employee: Abbott Dr Pollack - Employee: Abbott Dr Kumar - Employee: Abbott Dr Kampman - Employee: Abbott Dr Lazar - Employee: Abbott.Table: [1177]
PIN/Preamp receiver modules for 40-Gb/s optical communication systems (2002)

The PIN/Preamp receiver modules suitable for 40 Gb/s optical communication systems are presented. The waveguide PIN photodiodes with a polarization insensitive spot size converter and a GaAs pHEMT traveling wave amplifiers (TWA), which have a typical transimpedance of 150 ohms and a linear operating output voltage more than 700 mVpp, have been assembled in hermetic sealed compact packages. The receiver modules have the responsivity greater than 0.72 A/W, the polarization dependent loss less than 0.2 dB in the wavelength range from 1510 nm to 1620 nm, 45 GHz bandwidth, and the input equivalent noise current density less than 15 pA/sqrtHz. The wide eye opening has been confirmed at the average optical input power of -12 dBm in both 40 Gb/s RZ and NRZ data format. The sensitivity less than -11 dBm has been achieved at BER = 1 x 10^-9 in 40 Gb/s PRBS 2^7-1 NRZ signal. These results indicate that this receiver module can be used not only in long haul application but also in the very short haul application.
Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage (2011)

The renin-angiotensin system is a well-known regulator of blood pressure and plays an important role in the pathogenesis of cardiovascular disease and renal damage. Genetic factors, including single nucleotide polymorphisms and sex, are increasingly recognized as potential risk factors for the development of cardiovascular disease. Double transgenic rats (dTGRs), harboring human renin and angiotensinogen genes, were used in this study to investigate potential sex differences influencing renal function and renal gene expression. dTGR males and females had comparable increases in blood pressure, whereas body weight, albuminuria/proteinuria, and urine flow rate were higher in males. At 8 weeks of age, renal plasma flow and glomerular filtration rate were proportionally lower in males, and renal vascular resistance tended to be higher. Males developed more severe tubulointerstitial and vascular lesions. By the end of week 8, 40%of the males but none of the females had died. Genome expression studies were performed with RNA from kidneys of 7-week-old male and female dTGRs and control rats to further investigate the sex-related differences on a molecular level. Forty-five genes showed sex-dependent expression patterns in dTGRs that were significantly different compared to controls. Cathepsin L, one of the genes differentially expressed between the sexes, was also shown to be strongly associated with the degree of renal injury. In dTGRs, urinary cathepsin L at week 7 was higher in males (nanograms per 24 hours: male, 512±163; female, 132±70). These results reveal a potential new biomarker for the personalized diagnosis and management of chronic kidney disease.
Two New Biologically Active Cyclopentenones from Dasyscyphus sp. A47‐98. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Hydrogen Games and Other Adventures in Chemistry (2012)

I seem to have started off on the wrong foot in life, but I am extremely fortunate that I soon found my footing in the company of physical chemists. I consider myself to be very lucky to be doing something that constantly brings me in contact with bright minds, stimulating conversations, and exciting experiments. My work has allowed me to learn astounding facts about the molecules and atoms that make up our surroundings and ourselves. For this article, I focus on one aspect of my research, understanding the fundamental principles of the simple reaction between a hydrogen atom and a hydrogen molecule. Although my group and others have been studying this seemingly simple reaction for well over 30 years, it continues to provoke questions about the properties of matter.
Jeu vidéo : l'avenir de l'homme ? (2012)

Les jeux vidéo mettent en œuvre des mécanismes qui produisent sur notre cerveau des effets bénéfiques inégalés
Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis (1994)

The enzymic oxidn. of isoniazid by the catalase-peroxidase of Mycobacterium tuberculosi was studied. The reaction products suggest two reaction pathways involving both electrophilic and radical species. Labeling expts. are consistent with a reaction mechanism involving the formation of an acyldiimide intermediate followed by decompn. to the corresponding aldehyde and peracid. The results suggest that isoniazid is oxidized by the catalase-peroxidase to a reactive species that may act by inactivating an essential enzyme of M. tuberculosis. [on SciFinder (R)]
ChemInform Abstract: Stereoselective Cyanohydrin Forming Reactions of Chiral α‐Amino Aldehydes. (1988)

Abstract The chiral α‐aminoaldehydes (I) derived from the corresponding amino acids, are treated with trimethylsilyl cyanide (II) in the presence of various Lewis acids to form mixtures of the diastereomeric cyanohydrins (III) and (IV).
An acoustic system for autonomous navigation and tracking of marine fauna (2014)

A marine acoustic system for underwater target tracking is described. This system is part of the Integrated Satellite and Acoustic Telemetry (iSAT) project to study marine fauna. It is a microcontroller-based underwater projector and receiver. A narrow-band, passive sonar detection architecture is described from signal generation, through transduction, reception, signal processing and up to tone extraction. Its circuit and operation principles are described. Finally, a comparison between the current energy detection method versus an alternative matched filter approach is included.
Growth Mode and Defect Evaluation of GaSb on GaAs Substrate: A Transmission Electron Microscopy Study (2011)

We use transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) techniques to confirm and analyze the interfacial misfit (IMF) and non-IMF growth modes for GaSb epilayers on GaAs substrates. Under optimized IMF growth conditions, only pure 90 degrees dislocations are generated along both [110] and [1-10] directions and located exactly at the epi-substrate interface, which leads to very low density of misfit dislocations propagating from the GaSb/GaAs interface along the growth direction, compared to the non-IMF growth condition. The mechanism of defect annihilation indicates that this IMF mergence process happens without formation of threading dislocations into the GaSb epilayer, which is a completely relaxed growth mode with extremely low defect density. Based on scanning several sets of wafer surfaces, plan-view TEM confirms that the misfit defect densities are estimated to be approximately 5 x 10(5) cm(-2) for IMF growth mode and approximately 10(9) cm(-2) for non-IMF growth mode.
Blue light effect on retinal pigment epithelial cells by display devices (2017)

Blue light has high photochemical energy and induces cell apoptosis in retinal pigment epithelial cells. Due to its phototoxicity, retinal hazard by blue light stimulation has been well demonstrated using high intensity light sources. However, it has not been studied whether blue light in the displays, emitting low intensity light, such as those used in today's smartphones, monitors, and TVs, also causes apoptosis in retinal pigment epithelial cells. We attempted to examine the blue light effect on human adult retinal epithelial cells using display devices with different blue light wavelength ranges, the peaks of which specifically appear at 449 nm, 458 nm, and 470 nm. When blue light was illuminated on A2E-loaded ARPE-19 cells using these displays, the display with a blue light peak at a shorter wavelength resulted in an increased production of reactive oxygen species (ROS). Moreover, the reduction of cell viability and induction of caspase-3/7 activity were more evident in A2E-loaded ARPE-19 cells after illumination by the display with a blue light peak at a shorter wavelength, especially at 449 nm. Additionally, white light was tested to examine the effect of blue light in a mixed color illumination with red and green lights. Consistent with the results obtained using only blue light, white light illuminated by display devices with a blue light peak at a shorter wavelength also triggered increased cell death and apoptosis compared to that illuminated by display devices with a blue light peak at longer wavelength. These results show that even at the low intensity utilized in the display devices, blue light can induce ROS production and apoptosis in retinal cells. Our results also suggest that the blue light hazard of display devices might be highly reduced if the display devices contain less short wavelength blue light.
Symmetric pseudocapacitors based on molybdenum disulfide (MoS2)-modified carbon nanospheres: correlating physicochemistry and synergistic interaction on energy storage (2016)

Flower-like MoS<sub>2</sub>modified with carbon nanospheres (CNS) displays energy-storage capability when used as an aqueous symmetric pseudocapacitor.
Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of unfused aromatic cations to DNA. The influence of molecular twist on intercalationW. David. Wilson, Lucjan. Strekowski, Farial A. Tanious, Rebecca A. Watson, Jerzy L. Mokrosz, Alewtina. Strekowska, Gordon D. Webster, and Stephen. NeidleCite this: J. Am. Chem. Soc. 1988, 110, 25, 8292–8299Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/ja00233a003https://doi.org/10.1021/ja00233a003research-articleACS PublicationsRequest reuse permissionsArticle Views252Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
800 Mbit/s/ch×12 ch, true DC-coupled parallel optical interconnects using single-mode fiber and 1310 nm LD array (2002)

We developed 800 Mbit/s/ch, 12 ch, DC-coupled parallel optical interconnect modules, and confirmed high speed parallel transmission. For skew reduction between channels, we use single mode fiber array. In transmitter module, laser turn-on delay time is reduced by edge-pulse modulation method. In receiver module, 4 GHz-bandwidth receiver IC enables one to suppress waveform distortion caused by optical power variation. For assemblability and reliability, planar micro lens arrays are used for optical coupling and hermetic sealing.
Supplementary Figure S2 from The CARMA3–Bcl10–MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor–Positive Breast Cancer (2023)

&lt;p&gt;Constitutive and Ang II-induced NFkB activity in BT549 and ZR75-AGTR1 cells; dependence on AGTR1 and the canonical IKK complex.&lt;/p&gt;
Mass spectrometric and electron impact study of the spatial separation of mixtures of butane and argon in a pulsed supersonic jet (1997)

The spatial distribution of a pulsed molecular beam of butane seeded in Ar has been monitored by a movable mass spectrometer. The same beam has also been subjected to electron impact measurements, which provide additional information on the properties of the beam. Both measurements were carried out over a wide range of stagnation pressures. Substantial separation of gases, both across and along the jet, was observed. Some other mixtures were also tested for the existence of the separation effect. In several cases, there was no correlation between the value of the separation effect and the ratio of molecular masses of the mixed gases. These phenomena are accounted for by the formation of large clusters of the carrier gas, with guest molecules embedded in them.
NEAR-NAVIGATION GRADE QUAD MASS GYROSCOPE WITH Q-FACTOR LIMITED BY THERMO-ELASTIC DAMPING (2016)

This paper presents experimental results on the noise performance of an ultra high quality factor (Q-factor) micromachined silicon Quad Mass Gyroscope (QMG). The device was vacuum sealed at below 0.1mTorr in an LCC package with activated getters, demonstrating the Q-factor better than 1.7 million, along the drive and sense modes, at the 1.6 kHz center frequency. A bias stability of 0.09 deg/hr and Angle Random Walk (ARW) of 0.015 deg/rt-hr were demonstrated, without any thermal compensation or post-processing of data. To the best of our knowledge, the result presented in this paper is the highest reported Q-factor for MEMS silicon gyroscopes, now demonstrating a true potential to achieve the navigation-grade performance.
MOCVD growth and regrowth of quantum cascade lasers (2007)

MOCVD grown quantum cascade lasers (QCLs) have demonstrated about the same level performance as MBE grown QCLs. With the regrowth capability to fabricate buried heterostructure (BH) waveguides, the QCL output power has been dramatically increased and that opens the door to many mid-IR (and THz) applications. With the stable and high growth rate to produce high performance and reliable BH lasers, commercialization of QCLs with reasonable qualification and affordable price becomes possible. Furthermore with a good gain material and the etching and regrowth capability, optoelectronic integration can be realized using MOCVD growth techniques. We compare the MBE and MOCVD growth techniques and discuss important issues on growth rate stabilization and the control of growth quality at the hetero-interface. We also go over a few growth and integration examples we are working on that are preferentially done by MOCVD. Finally we describe a detailed QCL BH regrowth study and discussed how that can be done right.
Quasi-resonant converter with divided resonant capacitor on primary and secondary side (2009)

This paper presents a quasi-resonant converter with divided resonant capacitor on primary and secondary side of the isolation transformer. A conventional quasi-resonant converter using flyback topology can realize soft switching with simple circuit. However, relatively large surge voltage is generated in the switching device. To suppress such surge voltage, resonant capacitor is divided on primary side and secondary side in the proposed converter. In case of prototype 95 W converter, the voltage applied to switching device of proposed converter has been 26% lower than that of conventional converter. In addition, efficiency of proposed converter has been 1% higher than that of conventional converter.
Study of jet quenching with isolated-photon+jet correlations in PbPb and pp collisions at sNN=5.02 TeV (2018)

Measurements of azimuthal angle and transverse momentum ( ) correlations of isolated photons and associated jets are reported for and PbPb collisions at . The data were recorded with the CMS detector at the CERN LHC. For events containing a leading isolated photon with and an associated jet with , the photon+jet azimuthal correlation and imbalance in PbPb collisions are studied as functions of collision centrality and . The results are compared to reference data collected at the same collision energy and to predictions from several theoretical models for parton energy loss. No evidence of broadening of the photon+jet azimuthal correlations is observed, while the ratio decreases significantly for PbPb data relative to the reference. All models considered agree within uncertainties with the data. The number of associated jets per photon with is observed to be shifted towards lower values in central PbPb collisions compared to collisions.
Gabapentin for overactive bladder and nocturia after anticholinergic failure (2004)

Introduction: We reviewed our experience with the use of gabapentin to treat symptoms of overactive bladder (OAB) and nocturia in patients who have failed conventional anticholinergic therapy.
Data-rate constrained lattice vector quantization: a new quantizing algorithm in a rate-distortion sense (2002)

This paper describes an image coding scheme using lattice vector quantizers where the emphasis is put on a new lattice vector quantization approach. The adaptive signal decomposition uses wavelet packets which allow to best match the decomposition to the signal non-stationary characteristics. The quantizers used here are data rate constrained lattice vector quantizers. A classical rate-distortion algorithm [Ramchandran and Vetterli, 1993] based on two nested optimization processes allows to jointly optimize transformation and quantization and is used as a first step in the quantization procedure described here. It allows to define in each subband the lattice spacing (or scaling factor) minimizing the overall distortion for a given bit rate and to choose by a pruning algorithm the best structure of decomposition. An additional procedure developed here allows (by exploiting the lattice properties) to project a vector on a lattice point providing a better rate-distortion tradeoff. In addition, a new partitioning of the vector space allowing to divide the source of vectors into three sub-sources is introduced in order to improve the coding efficiency. In the rate distortion plane, this new quantization procedure brings a significant improvement of about 0.5-0.6 dB with respect to the classical rate-distortion algorithm.
AQUA: An Amphibious Autonomous Robot (2007)

AQUA, an amphibious robot that swims via the motion of its legs rather than using thrusters and control surfaces for propulsion, can walk along the shore, swim along the surface in open water, or walk on the bottom of the ocean. The vehicle uses a variety of sensors to estimate its position with respect to local visual features and provide a global frame of reference
Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix (2021)

Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development. The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture. Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica. X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface. Films exhibit ultimate strength up to 573 MPa. Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%). Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
<title>Neutron- and gamma-irradiated optical property changes for the final optics of the National Ignition Facility</title> (1995)

Based on studies we have performed with several radiation sources such as pulsed nuclear reactors, we have been able to construct a physical picture and measure quantitative parameters necessary to model the radiation-induced losses expected for fused silica and fused quartz National Ignition Facility (NIF) target area. It is important to note that these surrogate radiation sources do not have identical temporal and spectral characteristics to NIF, therefore caution is in order since the results obtained to date must be extrapolated somewhat to predict NIF performance.
ChemInform Abstract: A New Synthesis of D‐Glycosiduronates from Unprotected D‐Uronic Acids. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.