gebhart/patrepeval huggingface dataset:
The ALK-2 Inhibitor, TP-0184, Demonstrates High Distribution to the Liver Contributing to Significant Preclinical Efficacy in Mouse Models of Anemia of Chronic Disease (2016)

Abstract In individuals with chronic inflammatory diseases, such as cancer or rheumatoid arthritis, constitutive signaling through ALK2, a member of the bone morphogenetic protein (TGFβ/BMP) receptor family, leads to debilitating anemia, commonly referred to as anemia of chronic disease (ACD). Activation of ALK2, like other members of the BMP receptor family, leads to the phosphorylation and activation of SMAD family transcription factors via signal transduction and subsequent activation of gene expression. Activation of ALK2 in the liver induces the SMAD-driven transcription of the peptide hormone hepcidin which, by promoting the degradation of the iron transporter ferroportin, leads to reduced serum iron levels and subsequent functional anemia. Lowering constitutively elevated hepcidin levels by inhibiting ALK2 kinase activity is a potentially viable therapeutic strategy for ACD. Current therapeutic approaches for ACD rely on transfusions, intravenous iron and the use of erythropoietin-based therapies, none of which address the underlying pathological deficit of functionally low iron levels. TP-0184 is a small-molecule, selective inhibitor of ALK2 kinase activity (IC50 = 5 nM). TP-0184 has demonstrated profound preclinical activity in three mouse efficacy models for ACD. In model 1, TP-0184 reversed hepcidin induction in mice treated with turpentine oil. In model 2, TP-0184 abrogated reductions in hemoglobin and total red blood cell counts induced by intraperitoneal injection with heat-inactivated Brucella abortus. In model 3, TP-0184 reversed elevated hepcidin levels in TC-1 tumor bearing mice. Plasma and liver pharmacokinetics in mice revealed that TP-0184 has a high volume of distribution (Vd = 30.8) and accumulates at high concentrations in the liver (Cmax of 292 mM following a single oral dose of at 20 mg/kg). In rat multi-dose tolerability studies, TP-0184 caused no adverse effects when dosed at 200 mg/kg for 7 days, far exceeding the dose levels required to produce efficacy (25 mg/kg). These data suggest that favorable distribution to the liver may play a significant role in the preclinical efficacy of TP-0184 and provide evidence of a significant therapeutic window. Collectively these studies support the clinical evaluation of TP-0184 as an alternative treatment for ACD. Disclosures Peterson: Tolero Pharmaceuticals: Employment. Kim:Tolero Pharmaceuticals: Employment. Haws:Tolero Pharmaceuticals: Employment. Whatcott:Tolero Pharmaceuticals: Employment. Siddiqui-Jain:Tolero Pharmaceuticals: Employment. Bearss:Tolero Pharmaceuticals: Employment, Equity Ownership, Patents &amp; Royalties. Warner:Tolero Pharmaceuticals: Employment, Equity Ownership, Patents &amp; Royalties.
Querying and Tracking Influencers in Social Streams (2016)

Influence analysis is an important problem in social network analysis due to its impact on viral marketing and targeted advertisements. Most of the existing influence analysis methods determine the influencers in a static network with an influence propagation model based on pre-defined edge propagation probabilities. However, none of these models can be queried to find influencers in both context and time-sensitive fashion from a streaming social data. In this paper, we propose an approach to maintain real-time influence scores of users in a social stream using a topic and time-sensitive approach, while the network and topic is constantly evolving over time. We show that our approach is efficient in terms of online maintenance and effective in terms various types of real-time context- and time-sensitive queries. We evaluate our results on both social and collaborative network data sets.
LIGHT contributes to early but not late control of Mycobacterium tuberculosis infection (2010)

The TNF superfamily member, LIGHT, contributes to optimal T-cell activation in vitro through co-stimulation of dendritic cell cytokine production; however, its role in T-cell-mediated control of intracellular bacterial infections is unknown. Protective immunity against Listeria monocytogenes and Mycobacterium tuberculosis infection requires both antigen-specific CD4(+) and CD8(+) T cells. Using LIGHT-deficient mice we determined that LIGHT was necessary for optimal re-stimulation of anti-listerial CD8(+) T cells in vitro. By contrast, LIGHT(-/-) mice infected with L. monocytogenes generated equivalent T-cell responses and controlled the infection as effectively as normal C57BL/6 mice. Following M. tuberculosis infection, LIGHT(-/-) mice showed a significant increase in bacterial replication in the lungs at 4 weeks, but by 6 weeks had controlled the infection. Analysis of T-cell responses in vivo revealed that LIGHT was dispensable for the activation of primary T-cell responses and the production of IL-12 and IFN-gamma. In addition, LIGHT was not required for the induction of memory T-cell responses to anti-mycobacterial DNA or BCG vaccines and for subsequent protection against tuberculosis challenge. Therefore, LIGHT contributes to the optimal co-stimulation of anti-listerial CD8(+) T-cell responses in vitro and to the early control of M. tuberculosis infection; however, other mechanisms compensate for LIGHT deficiency in the control of these pathogens in vivo.
Viscosity and Surface Tension of Fluorene and Perhydrofluorene Close to 0.1 MPa up to 573 K (2022)

In the present study, the liquid viscosity and surface tension of fluorene (H0-F) and its fully hydrogenated counterpart perhydrofluorene (H12-F), representing process-relevant byproducts of the liquid organic hydrogen carrier (LOHC) system based on diphenylmethane and dicyclohexylmethane and potentially interesting LOHC compounds by themselves, were determined close to 0.1 MPa using different experimental methods. Besides surface light scattering (SLS) allowing for a simultaneous access to both properties up to 573 K, conventional methods in the form of capillary viscometry and pendant-drop tensiometry were applied up to (473 and 523) K, respectively. Furthermore, the liquid density of H12-F was measured by vibrating-tube densimetry from (283 to 473) K. While agreement of the viscosity and surface tension results obtained by SLS and the conventional methods is found in the case of H12-F, this is not given for H0-F, especially with respect to its surface tension, which seems to be caused by SLS-specific effects. H0-F exhibiting a melting point of about 384 K shows larger values for density, surface tension, and viscosity compared to H12-F being liquid at 283 K. The latter compound features stereoisomerism which appears to have a pronounced effect on the thermophysical properties. This could be deduced by comparison with the very limited amount of experimental data for the fluorene-based substances that are available in the literature so far. The extension of the thermophysical property database for H0-F and H12-F under process-relevant conditions can be useful for future studies, particularly in the field of chemical hydrogen storage.
Intrinsic paramagnetism and aggregation of manganese dopants in SrTiO3 (2014)

Using local-probe magnetic-characterization techniques of muon spin relaxation and electron spin resonance we have investigated the Mn-induced magnetism of the wide-band-gap perovskite SrTiO${}_{3}$. Our results clearly demonstrate that this diluted magnetic oxide remains paramagnetic down to low temperatures for both doping cases, i.e., when Mn substitutes for Sr or Ti. In addition, both experimental techniques have revealed that the distribution of individual Mn${}^{2+}$ and Mn${}^{4+}$ ions is nonrandom, as these ions partially aggregate into nanosized clusters.
Synthesis of Cyclohexane-Angularly-Fused Triquinanes (2020)

Cyclohexane-angularly-fused triquinanes, 6-5-5-5 tetracycles, have attracted the attention of synthetic chemists due to their highly congested core structures and multiple quaternary carbon centers. This review focuses on the six completed total synthesis of naturally occurring cyclohexane-angularly-fused triquinanes in addition to seven notable methodologies that have been developed for the synthesis of these structures.
Informed Watermark Embedding In The Fractional Fourier Domain (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Direct and indirect optimization of linear time-invariant dynamic systems using transformations (1998)

This paper deals with optimal trajectory generation of linear dynamic systems commanded between two fixed states in a prescribed final time. From the literature, it is well known that the optimal solution of this problem satisfies first-order linear differential equations in the state and costate variables. In this paper, a new procedure is presented for optimization where transformations are used to embed the state equations explicitly into the cost functional. The resulting transformed functional is then solved by both direct and indirect methods. The computational trade-offs of these methods are discussed. Copyright © 1998 John Wiley & Sons, Ltd.
Low phase noise CO-MB-OFDM optical burst transmitter for time and spectral optical aggregation (2017)

International audience
A SQUID biomagnetometer system for measurement of a human cervical spinal cord evoked field (2006)

The following article falls within the scope of this special issue (ISEC'05) but was actually published in a previous issue of Superconductor Science and Technology volume 18, issue 12 (December 2005), pages S303–S307. It may be accessed online from the link above or from stacks.iop.org/SUST/18/S303.
Melanin concentrating hormone (MCH) effects on teleost (Chrysiptera cyanea) melanophores (1985)

The in vitro biological actions of synthetic chum salmon melanin concentrating hormone (MCH) on melanophores of the blue damselfish (a teleost), Chrysiptera cyanea, were studied. This cyclic heptadecapeptide stimulated melanosome (melanin granule) aggregation (centripetal migration) within melanophores at a threshold concentration of about 10(-10) M. The action of this putative hormone was not blocked by alpha- or beta-adrenoceptor antagonists. It was concluded that the effects of MCH were direct and were not mediated indirectly through the actions of adrenergic neurotransmitters released from nerve terminals. Further evidence for this view comes from the observation that, unlike the case of neurotransmitter release, melanosome aggregation in response to MCH proceeded in the absence of calcium. The possible role of MCH in the control of color change of teleost fishes is discussed.
Model-based inversion of multiple nuclear measurements in high-angle wells (2016)

Nuclear measurements in high-angle wells, such as density, neutron, and sigma logs, are often affected by shoulder bed effects and should not be processed directly by the methods which are typically used in vertical wells. Those measurements also have their own unique features and different depth of investigations because of the distinguishing physical principles. It is difficult to have a common formation model that reconstructs the tool responses for all the measurements. In order to remove the geometrical effects and build a consistent formation model among density, neutron, and sigma measurements, we developed a model-based inversion for multiple nuclear measurements in high-angle wells. The inversion algorithm has been validated using synthetic data and applied to field data set. Compared to the input measurements, the inversion results show consistent models, and provide more accurate layer petrophysical properties. Presentation Date: Thursday, October 20, 2016 Start Time: 8:55:00 AM Location: 168 Presentation Type: ORAL
Load dump protection in 42 V automotive electrical distribution systems (2002)

Load dump protection in 42 V automotive systems can be provided by combining the use of both active control and passive transient voltage suppression devices (TVS). TVS devices currently available for automotive systems are analyzed and evaluated against the newly proposed 42 V bus voltage specifications. A new monolithic TVS device concept based on power MOSFET technology is proposed to meet the new 42 V specifications. Various active control strategies are also discussed in the paper.
Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose (2013)

Doses of toceranib ranging from 2.4-2.9 mg/kg every other day provide drug exposure considered sufficient for target inhibition while resulting in an adverse event profile substantially reduced from that associated with the label dose of toceranib. This lower dose range of toceranib should be considered for future use in dogs with cancer.
Properties of Tree and Grass Pollen Allergens: Reinvestigation of the Linkage between Solubility and Allergenicity (1993)

In this study we reinvestigated the kinetics of allergen release from birch pollen (Betula verrucosa) and timothy grass pollen (Phleum pratense) using different protein extraction procedures, immunoblotting with specific antibodies and immune electron microscopy. Pollen allergens such as the major birch pollen allergen, Bet v I, the major timothy grass pollen allergens, Phl p I and Phl p V, group-II/III allergens from timothy grass and profilins were released rapidly and in large amounts from hydrated pollen. Within a few minutes pollen allergens could be detected in aqueous supernatants prepared from birch and grass pollen with serum IgE or specific antibodies. In parallel the allergen content in the pollen pellet fractions decreased. A nonallergenic protein such as heat shock protein 70 can be extracted in sufficient amounts only with harsh extraction procedures. Immune electron microscopy of dry and rehydrated birch pollens showed that after short hydration, the major birch pollen allergen, Bet v I, migrated into the exine and to the surface of intact pollen grains, whereas profilin, against which a lower percentage of patients is sensitized, was retained in the pollen grain. Comparing the amino acid composition and hydrophilicity of the tested allergens with a nonallergenic protein such as heat shock protein 70, no significant difference was noted. In agreement with earlier observations we conclude that the allergenic properties of proteins are rather linked to the amount and speed of solubility from airborne particles than to intrinsic properties.
Selective Etching of Semicrystalline Polymers:  CF4 Gas Plasma Treatment of Poly(ethylene) (1999)

A series of poly(ethylene) (PE) films with different degrees of crystallinity was treated with a radio-frequency tetrafluoromethane (CF4) gas plasma (48−49 W, 0.06−0.07 mbar, and continuous vs pulsed treatment). The etching behavior and surface chemical and structural changes of the PE films were studied by weight measurements, X-ray photoelectron spectroscopy (XPS), static and dynamic water contact angle measurements, scanning electron microscopy (SEM), and atomic force microscopy (AFM). With increasing crystallinity (14−59%) of PE, a significant and almost linear decrease of the etching rate was found, ranging from 50 Å/min for linear low-density poly(ethylene) (LLDPE) to 35 Å/min for high-density poly(ethylene) (HDPE). XPS analysis revealed that after CF4 plasma treatment the PE surfaces were highly fluorinated up to F/C ratios of 1.6. Moreover, CF4 plasma treatment of PE resulted in extremely hydrophobic surfaces. Advancing water contact angles up to 150° were measured for treated LDPE films. Both SEM and AFM analysis revealed that pronounced surface restructuring took place during prolonged continuous plasma treatment (≥15 min). The lamellar surface structure of LDPE changed into a nanoporous-like structure with uniform pores and grains on the order of tens of nanometers. This phenomenon was not observed during plasma treatment of HDPE films. Apart from surface roughening due to selective etching, pulsed plasma treatment did not result in significant surface structural changes either. Therefore, the restructuring of continuously plasma-treated surfaces was attributed to a combined effect of etching and an increase of the surface temperature, resulting in phase separation of PE-like and poly(tetrafluoroethylene)-like material, of which the latter is surface oriented.
Babyhamsternieren-Zellen als Antigen für den Nachweis von antinukleären Antikörpern (1978)

Baby hamster kidney cells fixed in acetone on glass slides were used as antigen for demonstration of antinuclear antibodies. Where certain storage conditions were observed (drying agent, 4 degrees C) they have kept for 12 months up to now. As regards specificity, sensitivity, reproducibility, and differentiation of fluorescent types the baby hamster kidney cell test appears superior to other immunofluorescence methods used (chicken erythrocytes, rat liver sections, and crithidiae). These results were obtained in 73 sera from patients with disseminated lupus erythematodes, drug-induced lupus erythematodes, discoid erythematodes, allergic vasculitis, progressive scleroderma, dermatomyositis, and 36 control sera.
The behavioral, cellular and immune mediators of HIV-1 acquisition: New insights from population genetics (2020)

Millions are exposed to the human immunodeficiency virus type 1 (HIV-1) every year, but not all acquire the virus, suggesting a potential role for host genetics in the moderation of HIV-1 acquisition. Here, we analyzed summary statistics from the largest genome-wide association study of HIV-1 acquisition to-date, consisting of 6,334 infected patients and 7,247 population controls, to advance our understanding of the genetic mechanisms implicated in this trait. We found that HIV-1 acquisition is polygenic and heritable, with SNP heritability estimates explaining 28-42% of the variance in this trait at a population level. Genetic correlations alongside UK Biobank data revealed associations with smoking, prospective memory and socioeconomic traits. Gene-level enrichment analysis identified EF-hand calcium binding domain 14 as a novel susceptibility gene for HIV-1 acquisition. We also observed that susceptibility variants for HIV-1 acquisition were significantly enriched for genes expressed in T-cells, but also in striatal and hippocampal neurons. Finally, we tested how polygenic risk scores for HIV-1 acquisition influence blood levels of 35 inflammatory markers in 406 HIV-1-negative individuals. We found that higher genetic risk for HIV-1 acquisition was associated with lower levels of C-C motif chemokine ligand 17. Our findings corroborate a complex model for HIV-1 acquisition, whereby susceptibility is partly heritable and moderated by specific behavioral, cellular and immunological parameters.
Effect of noble gases on the properties of ion beam sputtered niobium films (1989)

We present result to support our hypothesis that the reflection of the primary beam during ion−beam sputtering of niobium films plays a significant role in determining final film properties, especially in the case of ion−beam sputtering. The film properties are afected by both the noble gas incorporation in and noble−gas bombardment of the growing film. (AIP)
Whole-Body Spectroscopy (BCM) in the Assessment of Normovolemia in Hemodialysis Patients (2008)

Whole-body impedance spectroscopy (BCM) has been validated by comparing isotope dilution methods for precisely measuring body volume compartments. Clinical assessment as well as comparison to other methods shows that BCM predicts a reliable individual dialysis target weight in kilograms, which corresponds to a physiological (normal) extracellular volume. BCM is helpful in the management of volume status and arterial hypertension in hemodialysis patients as well as in patients with chronic kidney disease. Quantified by BCM, overhydration is a powerful predictor of death in hemodialysis patients.
ChemInform Abstract: A Highly Chemo‐ and Stereoselective Synthesis of β‐Keto Esters via a Polymer‐Supported Lipase Catalyzed Transesterification. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Estimation of sheet modulus of elasticity using drive field signals (2011)

Online sensing of sheet modulus of elasticity in the dry-end spans of printing grade paper machines will permit the machine operators to control the mechanical properties of the produced paper. This paper develops an integrated, sensorless tension control and sheet modulus of elasticity estimation algorithm, which is tested using field recorded signals from a production paper machine and using a full model of the dry-end sections of this machine. Results show the ability of the proposed estimation algorithm to predict the sheet tension (tensile force) and sheet modulus of elasticity even in the presence of rapid changes in the speed and/or in other process operating conditions. The developed algorithms offer the papermaker new insights into the papermaking process. The ability to understand how modulus changes in real time provides a pathway to optimizing the operation of the paper machine drive system.
Peptides as Conformational Switch: Medium‐Induced Conformational Transitions of Designed Peptides (1990)

The synthetic oligopeptide I undergoes a spontaneous, reversible transition from an α‐helix to a β‐sheet structure in mixtures of 45% 2,2,2‐trifluoroethanol and 55% H 2 O. The amphiphilic oligopeptide 1 and two isomers were expressly designed for this investigation. Such peptides, which can exist in several conformations, might find application as “switches” in the de novo design of artificial proteins. equation image
Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis (2021)

Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically oxidized to oxysterols and bile acids (BAs) to promote its removal. In contrast, the auto oxidation of excess cholesterol is often detrimental to cellular survival. Although oxidized metabolites of cholesterol are altered in the blood and CSF of ALS patients, it is unknown if increased cholesterol oxidation occurs in the SC during ALS, and if exposure to oxidized cholesterol metabolites affects human MN viability. Here, we show that in the SOD1<sup>G93A</sup> mouse model of ALS that several oxysterols, BAs and auto oxidized sterols are increased in the lumbar SC, plasma, and feces during disease. Similar changes in cholesterol oxidation were found in the cervical SC of sporadic ALS patients. Notably, auto-oxidized sterols, but not oxysterols and BAs, were toxic to iPSC derived human MNs. Thus, increased cholesterol oxidation is a manifestation of ALS and non-regulated sterol oxidation likely contributes to MN death. Developing therapeutic approaches to restore cholesterol homeostasis in the SC may lead to a treatment for ALS.
Overview of Early-Stage Microchannel Reactor Development at Pacific Northwest National Laboratory (2005)

Investigation of microchannel reactors at Pacific Northwest National Laboratory (PNNL) began in the mid 1990s. During the half decade leading to 2000, many concurrent challenges were faced involving device design, catalyst development, and fabrication methods. Microchannel reactor development efforts at PNNL were focused on solving applied problems, including vaporization of hydrocarbon fuels and their steam reforming for fuel processing. Efforts at PNNL also focused on the development of engineered catalysts based on structured metal substrates and device fabrication using diffusion-bonded metal sheets.