gebhart/patrepeval huggingface dataset:
The frequency of the Bw4 KIR ligand is elevated among natal females and has increased in the southern community. (2016)

&lt;p&gt;(A) Patr-B*23:05 is the only Gombe Patr-B allotype that carries the Bw4 epitope, a ligand for KIR receptors of NK cells. Similarly, Patr-B*28:01 is the only Gombe Patr-B allotype that carries the C1 epitope, also a ligand for KIR. Shown are the temporal changes in the frequencies of &lt;i&gt;Patr-B*23:05&lt;/i&gt; (green bars) and &lt;i&gt;Patr-B*28:01&lt;/i&gt; (purple bars) in the three Gombe communities. In the northern and central communities, these frequencies were relatively stable, whereas in the southern community, there was a steady increase in the frequency of Bw4-bearing Patr-B*23:05 during 2000–2010 when the southern community was declining (Fisher’s Exact test, &lt;i&gt;p&lt;/i&gt; = 0.099). Although not significant, a monotonic increase in the frequency of C1-bearing Patr-B*28:01 is also seen. The earliest census year was 1995 for the central and northern communities, and 1998 for the southern community. The community frequency data for these alleles are provided in &lt;a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002144#pbio.1002144.s004" target="_blank"&gt;S4 Data&lt;/a&gt;. (B) This compares &lt;i&gt;Patr-B&lt;/i&gt; allele frequencies for natal (black bars) and immigrant (colored bars) female chimpanzees of the northern and central communities. The &lt;i&gt;Patr-B*23:05&lt;/i&gt; and &lt;i&gt;Patr-B*17:03&lt;/i&gt; alleles are enriched among natal females, but not immigrant females. Significance is denoted by asterisks (Fisher’s Exact tests, &lt;i&gt;p&lt;/i&gt;-values are given beneath the asterisks). The frequency data are provided in &lt;a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002144#pbio.1002144.s006" target="_blank"&gt;S6 Data&lt;/a&gt;.&lt;/p&gt;
Carboline derivatives with an ortho-linked terphenyl core for high quantum efficiency in blue phosphorescent organic light-emitting diodes (2013)

Two host materials, 9-(3''-(9H-carbazol-9-yl)-[1,1':2',1''-terphenyl]-3-yl)-α-carboline (CzOTCb) and 3,3''-bis(α-carbolin-9-yl)-1,1':2',1''-terphenyl (CbOTCb), derived from carboline and ortho-linked terphenyl were synthesized as high triplet energy materials and showed a high triplet energy of 2.90 eV. CzOTCb and CbOTCb were evaluated as the host materials for blue phosphorescent organic light-emitting diodes and high quantum efficiencies of 27.4% and 28.8% were obtained using the CzOTCb and CbOTCb hosts, respectively.
High-pressure x-ray diffraction study of Ta4AlC3 (2006)

Using a synchrotron radiation source and a diamond anvil cell, we measured the pressure dependence of the lattice parameters of a recently discovered phase, Ta4AlC3. This phase adopts a hexagonal structure with the space group P63∕mmc; at room conditions, the a and c parameters are 3.087(5) and 23.70(4)Å, respectively. Up to a pressure of 47GPa, no phase transformations were observed. Like Ta2AlC, but unlike many related phases such as Ti4AlN3, Ti3SiC2, Ti3GeC2, and Zr2InC, the compressibility of Ta4AlC3 along the c and a axes are almost identical. The bulk modulus of Ta4AlC3, 261±2GPa, is ≈4% greater than that of Ta2AlC. Both, however, are ≈37% lower than the 345±9GPa of TaC.
Artificial Intelligence and Early Detection of Pancreatic Cancer (2021)

Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly nonspecific. The premise of improved survival through early detection is that more individuals will benefit from potentially curative treatment. Artificial intelligence (AI) methodology has emerged as a successful tool for risk stratification and identification in general health care. In response to the maturity of AI, Kenner Family Research Fund conducted the 2020 AI and Early Detection of Pancreatic Cancer Virtual Summit (www.pdac-virtualsummit.org) in conjunction with the American Pancreatic Association, with a focus on the potential of AI to advance early detection efforts in this disease. This comprehensive presummit article was prepared based on information provided by each of the interdisciplinary participants on one of the 5 following topics: Progress, Problems, and Prospects for Early Detection; AI and Machine Learning; AI and Pancreatic Cancer-Current Efforts; Collaborative Opportunities; and Moving Forward-Reflections from Government, Industry, and Advocacy. The outcome from the robust Summit conversations, to be presented in a future white paper, indicate that significant progress must be the result of strategic collaboration among investigators and institutions from multidisciplinary backgrounds, supported by committed funders.
Structure-Based Drug Design Approaches for Predicting Binding Affinities of Hiv1 Protease Inhibitors (1998)

Computational assessment of the binding affinity of enzyme inhibitors prior to synthesis is an important component of computer-assisted drug design (CADD) paradigms. The free energy perturbation (FEP) methodology is the most accurate means of estimating relative binding affinities between two inhibitors. However, due to its complexity and computation-intensive nature, practical applications are restricted to analysis of structurally-related inhibitors. Accordingly, there is a need for methods that enable rapid assessment of large number of structurally-unrelated molecules in a suitably accurate manner. In this review, the FEP method is compared with regression-based methods that employ multivariate models to assess the advantages of each in the estimation of relative binding affinities of inhibitors to an enzyme. Semiquantitative predictions of relative binding free energies of human immunodeficiency virus 1 (HIV1) protease inhibitors are also presented and compared with the corresponding FEP results. The results indicate that the regression-based methods and the FEP method are useful in the semi-quantitative and quantitative assessment of relative binding affinities of enzyme inhibitors, respectively, prior to synthesis.
Changes in fucosyl-glycopeptides during early post-implantation embryogenesis in the mouse (1980)

Six-day to 12-day mouse embryos were dissected and radiolabelled by culture in the presence of [3H]fucose. The radiolabelled embryos were extensively digested with Pronase. The resulting glycopeptides were analysed by Sephadex G-50 column chromatography. Glycopeptides from 6-day-old embryos were separated into two main peaks: one eluted near the excluded volume, the other in a well-retarded position. This elution profile was similar to that observed with glycopeptides prepared from embryonal carcinoma cells. The relative amount of the high-molecular-weight glycopeptides decreased during embryonic development and particularly around day 9. Glycopeptide elution profiles from 10-day embryos, or isolated organs of 12-day embryos, were indistinguishable from those obtained from differentiated teratocarcinoma-derived or adult cells. At least 30% of the large molecular weight glycopeptides appear to be located at the cell surface.
Anti-Vibrio parahaemolyticus compounds from Streptomyces parvus based on Pan-genome and subtractive proteomics (2023)

Pangenome analysis of 58 <i>V. parahaemolyticus</i> genomes revealed that there were 1,392 core genes. After Subtractive proteomics and physiochemical checks, Flagellar motor switch protein FliN was selected as a therapeutic target against <i>V. parahaemolyticus</i>. FliN was modeled and docked with <i>Streptomyces parvus</i> source compounds, and Actinomycin D was identified as a potential anti-<i>V. parahaemolyticus</i> agent with a strong binding energy. Experimental verification confirmed its effectiveness in killing <i>V. parahaemolyticus</i> and significantly inhibiting biofilm formation and motility. This study is the first to use pan-genome and subtractive proteomics to identify new antimicrobial targets for <i>V. parahaemolyticus</i> and to identify the anti-<i>V. parahaemolyticus</i> effect of Actinomycin D. These findings suggest potential avenues for the development of new antibacterial drugs to control <i>V. parahaemolyticus</i> infections.
Research Report: Development of a Digital Phantom for Nuclear Medicine (2007)

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Magnetic field analysis of an ironless brushless DC machine (2005)

This paper presents an analytical solution for the magnetic field inside an unconventional ironless brushless (ILBL) dc motor design. We discuss the unique characteristics of the design, which adopts an "inside-out" construction with an internal ironless stator. With the intention of obtaining an analytical solution for the magnetic field, we propose a model based on a magnetic pole concept for representing the magnetic circuit. The magnetic field inside the motor, which has no iron for guiding magnetic flux paths, is obtained by solving Laplace's equation for magnetic scalar potential. We present both analytical and numerical solutions for the magnetic field and compare them with measured results of a 20-pole prototype IL design to show the validity of the model. The IL design is simple, easy to manufacture and, as indicated by the results, has an optimum number of magnets, for which its performance becomes maximum.
Advanced Aqueous Separation Systems for Actinide Partitioning (2012)

One of the most challenging aspects of advanced processing of spent nuclear fuel is the need to isolate transuranium elements from fission product lanthanides. This project expanded the scope of earlier investigations of americium (Am) partitioning from the lanthanides with the synthesis of new separations materials and a centralized focus on radiochemical characterization of the separation systems that could be developed based on these new materials. The primary objective of this program was to explore alternative materials for actinide separations and to link the design of new reagents for actinide separations to characterizations based on actinide chemistry. In the predominant trivalent oxidation state, the chemistry of lanthanides overlaps substantially with that of the trivalent actinides and their mutual separation is quite challenging.
Constructs used in transfection experiments. (2015)

&lt;p&gt;(A) Either the wild type, the c.-456_-453delCCTT or the c.-469C&gt;T containing 5′UTRs were cloned upstream the firefly luciferase gene. (B) The wild type/c.-456_-453delCCTT 5′UTR were subcloned upstream the &lt;i&gt;CDKN1B&lt;/i&gt; gene. (C) The introduction of the c.-428A&gt;T substitution in the two former plasmids reported in panel A restores uORF length and intercistonic distance. (D) Constructs reported in panel B were mutated introducing a c.-74insC leading to the translation of a chimeric protein in the double mutant.&lt;/p&gt;
DOUBLE BUNDLE ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION: AN IN VITRO BIOMECHANICAL STUDY (2006)

Objective: To compare double bundle ACL reconstruction kinematics to single bundle reconstruction, intact knee and ACL deficient knee employing an electromagnetic device in six cadaver knees under different antero-posterior and rotational loading conditions.

Methods: All the tests were performed with an intact ACL, with a deficient ACL and after single and double bundle ACL reconstruction.

In double bundle ACL reconstruction two tibial tunnels were drilled: for the anteromedial the 65 degrees Howell guide was employed; the posterolaetral was drilled through a prototype jig attached to the first guide. Two femoral tunnels were drilled outside-in with the Rear Entry guide. A 6 millimetres bovine tendon graft was employed and fixed to bone with interference screws.

Results: Posterior drawer loading conditions did not show differences between intact knee, single and double ACL reconstruction independently from rotational stresses.

Under an anterior drawer test double bundle ACL reconstruction restored anteroposterior laxity significantly better than single bundle reconstruction at 20 and 40 degrees of flexion. A trend towards a better rotational control of double bundle reconstruction was observed in extension.
Integration Architecture of Content Addressable Memory and Massive-Parallel Memory-Embedded SIMD Matrix for Versatile Multimedia Processor (2008)

This paper presents an integration architecture of content addressable memory (CAM) and a massive-parallel memory-embedded SIMD matrix for constructing a versatile multimedia processor. The massive-parallel memory-embedded SIMD matrix has 2,048 2-bit processing elements, which are connected by a flexible switching network, and supports 2-bit 2,048-way bit-serial and word-parallel operations with a single command. The SIMD matrix architecture is verified to be a better way for processing the repeated arithmetic operation types in multimedia applications. The proposed architecture, reported in this paper, exploits in addition CAM technology and enables therefore fast pipelined table-lookup coding operations. Since both arithmetic and table-lookup operations execute extremely fast, the proposed novel architecture can realize consequently efficient and versatile multimedia data processing. Evaluation results of the proposed CAM-enhanced massive-parallel SIMD matrix processor for the example of the frequently used JPEG image-compression application show that the necessary clock cycle number can be reduced by 86% in comparison to a conventional mobile DSP architecture. The determined performances in Mpixel/mm2 are factors 3.3 and 4.4 better than with a CAM-less massive-parallel memory-embedded SIMD matrix processor and a conventional mobile DSP, respectively.
Extracting and Leveraging Nodule Features with Lung Inpainting for Local\n Feature Augmentation (2020)

Chest X-ray (CXR) is the most common examination for fast detection of\npulmonary abnormalities. Recently, automated algorithms have been developed to\nclassify multiple diseases and abnormalities in CXR scans. However, because of\nthe limited availability of scans containing nodules and the subtle properties\nof nodules in CXRs, state-of-the-art methods do not perform well on nodule\nclassification. To create additional data for the training process, standard\naugmentation techniques are applied. However, the variance introduced by these\nmethods are limited as the images are typically modified globally. In this\npaper, we propose a method for local feature augmentation by extracting local\nnodule features using a generative inpainting network. The network is applied\nto generate realistic, healthy tissue and structures in patches containing\nnodules. The nodules are entirely removed in the inpainted representation. The\nextraction of the nodule features is processed by subtraction of the inpainted\npatch from the nodule patch. With arbitrary displacement of the extracted\nnodules in the lung area across different CXR scans and further local\nmodifications during training, we significantly increase the nodule\nclassification performance and outperform state-of-the-art augmentation\nmethods.\n
Using multicast communication to locate resources in LAN-based distributed system (2003)

The authors present a resource (e.g. file, process) location scheme which utilizes the multicast communication capability of local area networks (LANs). In the scheme, the universe of resource names is partitioned into a relatively small number of groups and each group is assigned a unique address. Nodes storing the locations of resources belonging to a particular group instruct their network interfaces to receive all location messages sent to the group address. To locate a resource, a node first determines the address of the group to which the resource belongs, and a multicast message is then sent to the address. The algorithm performance is studied by simulation, and approximate closed-form solutions are derived for systems operating at heavy and low loads. The scheme's performance is compared with that of broadcast, and it is shown that the proposed scheme performs much better than broadcast alone.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Forced Aerobic Exercise Preceding Task Practice Improves Motor Recovery Poststroke (2017)

People with chronic stroke can safely complete intensive aerobic exercise. Forced aerobic exercise may be optimal in facilitating motor recovery associated with task practice.
Synthesis of a New Template with a Built‐in Adjuvant and Its Use in Constructing Peptide Vaccine Candidates Through Polyoxime Chemistry (1996)

Synthetic lipopeptides are showing promise as vaccine candidates, but until now it has been very difficult to prepare them in homogeneous form. We describe the synthesis and characterization of a new water-soluble, four-branched template with a built-in lipophilic adjuvant (Pam3Cys). Through the use of oxime chemistry, we attached four copies of an unprotected influenza virus peptide and characterized the product (13 kDa) by reversed-phase HPLC and electrospray ionization mass spectrometry. Several other such constructions were made using the new template and different peptides. We seem to have a general method for making synthetic lipopeptides in homogeneous form.
Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome (2007)

An endothelin receptor blockade potentially can cause a deterioration in renal function in patients with cirrhosis and type 2 HRS. Caution should be taken in future studies using endothelin receptor antagonists in these patients.
Ab Initio Studies of Rhodium(I)−N-Alkenylamide Complexes with cis- and trans-Coordinating Phosphines:  Relevance for the Mechanism of Catalytic Asymmetric Hydrogenation of Prochiral Dehydroamino Acids (1997)

A theoretical study on cationic Rh(I)−N-alkenylamide complexes is presented, which are important intermediates in the asymmetric hydrogenation affording N-acylamino acids. The assumption of different intermediates investigated is based on the inter- and intramolecular equilibrium of diastereomeric complexes in the hydrogenation mechanism. The geometry optimizations were performed at the MP2 level of theory using relativistic pseudopotentials for rhodium, followed by QCISD(T) single-point calculations. The intermediates containing cis- or trans-coordinated phosphines have been compared structurally and energetically, and the influence of solvents is discussed. In the equilibrium consisting of uncoordinated substrate and substrate complexes, all tautomeric complexes were found in the calculation and have a minimum on the potential hypersurface. However, the occurrence of enamine/imine and amide/imine-ol tautomers could be excluded for the catalytic reaction, because they implement irreversible steps (C−H activation, deprotonation) which finish the catalytic cycle and may therefore be responsible for turnover-limiting steps. Only the calculation of an intermediate showing hetero-π-allyl type coordination can explain satisfactorily the crucial interconversion of the diastereomeric major/minor complexes in a noncoordinating medium. This intermediate is favored for the rationalization of the intramolecular equilibrium. For trans-coordinating diphosphine ligands a T-shaped intermediate with only a coordinated nitrogen atom is proposed.
Microporous and mesoporous electronic materials: Flexible open-framework nanomaterials for molecular recognition, towards the electronic nose (1995)

Abstract A novel class of flexible open-framework microporous tin(IV) chalcogenide electronic materials is described, whose structure-property relationships are sensitive to the identity and loading of the imbibed molecular guests. The discovery of these materials could represent an important step towards the practical realization of an abiological electronic nose. The inorganic character of their open-framework structures and the compositional tunability of their electronic band structures, makes these molecular recognition host-guest inclusion electronic materials, potentially integratable into transistor and diode array-type chemoselective devices. The research briefly described in this paper, demonstrates that certain key elements, considered to be central to the development of molecule discriminating sensors, have now been brought to practice with the nanoporous tin(IV) chalcogenide class of materials. A natural extension of this work has led to the discovery of novel mesoporous forms of these materials.
Polymorphism or mutation? - The role of the R304Q missense AIP mutation in the predisposition to pituitary adenoma (2016)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Carbanion-accelerated Claisen rearrangements. 8. Phosphonamide anion-stabilizing groups (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbanion-accelerated Claisen rearrangements. 8. Phosphonamide anion-stabilizing groupsScott E. Denmark, Heinz Stadler, Roberta L. Dorow, and Jung Ho KimCite this: J. Org. Chem. 1991, 56, 17, 5063–5079Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jo00017a016https://doi.org/10.1021/jo00017a016research-articleACS PublicationsRequest reuse permissionsArticle Views1146Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts