gebhart/patrepeval huggingface dataset:
Synthesis of the isomeric phenols and the trans-2,3-dihydrodiol of fluoranthene (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the isomeric phenols and the trans-2,3-dihydrodiol of fluorantheneJoseph E. Rice, Edmond J. LaVoie, and Dietrich HoffmannCite this: J. Org. Chem. 1983, 48, 14, 2360–2363Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/jo00162a012https://doi.org/10.1021/jo00162a012research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Un mapa de innovación centrado en el cliente (2008)

Todos sabemos que las personas �contratan� productos y servicios para hacer un trabajo. Los cirujanos contratan escalpelos para diseccionar tejido blando. Los conserjes contratan dispensadores de jabon y toallas de papel para ayudar a eliminar la suciedad de sus manos. Para identificar formas de innovar, es clave descomponer la tarea desde su principio hasta su finalizacion para que la empresa obtenga una imagen completa de todos los puntos en los cuales un cliente podria desear recibir mas ayuda de un producto o servicio. 
Una metodologia llamada trazar un mapa del trabajo ayuda a las empresas a analizar las mayores desventajas de los productos y servicios que los clientes utilizan actualmente y a descubrir oportunidades de innovacion. Implica desglosar la tarea que el cliente desea realizar en ocho pasos separados que forman un proceso universal: (1) definir los objetivos, (2) ubicar los insumos necesarios, (3) preparar el entorno fisico, (4) confirmar que este todo listo, (5) ejecutar la tarea, (6) controlar su progreso, (7) modificar segun los requerimientos, y (8) concluir el trabajo.
Los mapas de trabajo difieren sustancialmente de los mapas de procesos, ya que el objetivo de los primeros radica en identificar que tratan de hacer los clientes en cada etapa y no que estan haciendo efectivamente. Por ejemplo, cuando un anestesista revisa un monitor durante un procedimiento quirurgico, la accion es un medio para alcanzar un fin. El trabajo que el anestesista quiere hacer es detectar cambios en los signos vitales del paciente.
Dentro de cada una de estas etapas existen multiples oportunidades para innovar y hacer que el trabajo sea mas simple, mas facil y mas rapido. Al trazar un mapa de cada paso del trabajo y ubicar esas oportunidades, las empresas pueden descubrir nuevas formas de diferenciar sus ofertas.
Electronic Densities of States of Amorphous and Trigonal Se and Te (1974)

We have used the Empirical Pseudopotential Method to obtain electronic densities of states and charge distributions for the valence electrons in trigonal Se and Te. We have explored the relation between density of states structure and charge density. Specifically, structures in recent photoemission spectra are identified with particular interchain and intrachain bonding states. These results are then used to interpret the changes observed in the experimental photoemission spectra of amorphous Se and Te.
[Coraco-humeral space and rotator cuff tears]. (1999)

Measurements of the SCS in isolated lesions of the subscapularis show that the coracoïd process is not the mechanical factor responsible for tendon rupture. SCS narrowing is the consequence of a large cuff tear involving both the subscapularis and the infraspinatus tendon. Subscapularis tear is a necessary but not a sufficient condition by itself for SBS narrowing. Complete tear of the infraspinatus tendon and above all the muscular degeneration of the infraspinatus muscle is the other necessary condition for SCS narrowing. The horizontal control of the humeral head depends on subscapularis-infraspinatus muscular balance control. According to Patte's hypothesis SCS narrowing corresponds to an horizontal anterior translation of the humeral head due to fatty degeneration of subscapularis and infraspinatus muscle.
Energy-Delay Estimation Technique for High-Performance Microprocessor (2003)

In this paper, we motivate the concept of comparing VLSI adders based on their energy-delay trade-offs and present a technique for estimating the energy-delay space of various high-performance VLSI adder topologies. Further, we show that our estimates accurately represent tradeoffs in the energy-delay space for high-performance 32-bit and 64-bit processor adders in 0.13µm and 0.10µm CMOS technologies, with an accuracy of 8% in delay estimates and 20% in energy estimates, compared with simulated data.
Sensing RF Connector Tightness Using a Grounded Plate Capacitive Structure (2008)

This paper describes a grounded plate capacitive sensing technique for monitoring mated RF connector tightness. The capacitive sensing structure and conditioning electronics are fabricated on the surface of a small polystyrene disc which is integrated into the RF connector body. A model of the electrostatic-mechanical system accurately predicts the change in capacitance as a function of the torque applied to tighten the mated connectors. Mechanical displacement in the connector (or, indirectly, axial force on the mated connector) translates to a change in the period of an oscillator drive circuit. The sensing system is measured to provide a transducer sensitivity range from 0.15 pF/Nmiddotm at the initial connector mating force to 0.74 pF/Nmiddotm at the high end of mating force.
Superconducting nanocomposite films grown by chemical solution deposition: synthesis, microstructure and properties (2010)

This Thesis is focused on the preparation of novel functional metal-oxide nanocomposite films by solution-based deposition methodologies. One of the most outstanding results of this work is the capability to prepare epitaxial nanocomposite films with embedded randomly oriented nanoparticles leading to the formation of incoherent interfaces. Such incoherent interfaces had not been observed before in epitaxial nanocomposite films. Therefore, their influence on the surrounding matrix has been studied in detail in this work in terms of either nanostructure or physical properties. The nanocomposites films are based on an epitaxial YBa2Cu3O7 superconducting matrix in which non-superconducting oxide nanoparticles (i.e. BaZrO3 and Y2O3) are embedded in order to enhance the magnetic flux pinning properties. A thorough study of the nanoparticles texture as well as of the matrix nanostructure has been carried out by X-ray diffraction (XRD) techniques. Such investigations have led to understand the complex microstructure-properties relationship in these novel materials. In particular, it has been found that the incoherent interfaces arisen between the epitaxial matrix and the randomly oriented nanoparticles are the responsible of inducing strain at the nanoscale level (i.e. nanostrain) on the YBa2Cu3O7 lattice. The fact that nanostrain is higher in YBa2Cu3O7-BaZrO3 nanocomposites becoming also isotropic leads to the most efficient flux pinning properties in these novel materials, turning thus YBa2Cu3O7-BaZrO3 nanocomposites very promising for high field power applications From the chemical viewpoint, it has been studied the Chemical Solution Deposition methodology, in particular the precursor decomposition reaction. The analysis of both the solid and gaseous phases has permitted to determine the complete decomposition chemical reaction which was so far unknown. In addition, the porosity development in the as-decomposed films has been studied, being possible to reduce and even eliminate the undesired pores by reducing the oxidation power of the atmosphere.
SMOS Validation and the COSMOS Campaigns (2008)

The Soil Moisture and Ocean Salinity (SMOS) mission is a joint ESA-CNES (F)-CDTI (E) mission within the ESA Living Planet Program, and it was the second ESA Earth Explorer Opportunity Mission to be selected. The mission objectives of SMOS are to provide soil moisture and ocean salinity observations for weather forecasting, climate monitoring, and the global freshwater cycle. This paper will describe the scientific campaigns performed to date, as well as the plans for the on-orbit calibration and validation activities.
Numerical Investigation of the Pressure Drop Through Micro-Pillar Arrays for a Wide Range of Aspect Ratios (2013)

Accurate prediction of the pressure drop through micropillar arrays is essential for many micro total analysis system (μTAS) applications (e.g., liquid chromatography and filtration). Minimizing the pressure drop for such applications is often vital for performing their primary functions efficiently. In this paper, numerical investigation of pressure drop through square micropillar arrays with different pillar diameter and pitch was conducted. Finite volume discretization method was employed for the numerical simulations using commercial code. Simulation results were validated against experimental data from the literature. A parametric study of geometric variables (pillar diameter, pitch, and height) was performed. Models available from the literature for predicting the permeability of a 2D micropillar array were accessed by comparison to the numerical results. Both dimensional analysis and simulation results were used to develop a new model for square arrangements of micropillar arrays which shows good agreement with numerical simulation results for both 2D and 3D cases. The maximum absolute error between the 3D simulation results and predicted value of the pressure drop has been decreased from 67.3% using a model from the literature to only 1.9% using the proposed model.
Impact of matching network on the capacity of compact MIMO systems (2006)

MIMO is an undisputed breakthrough in advanced wireless technology, as it offers potentially linear increase in information-theoretic capacity with the number of antennas. However, the implementation of MIMO in compact terminals is a relatively uncharted topic, due to challenging problems with high antenna correlation and mismatch loss, both of which greatly reduces the expected MIMO gains. In this paper, we investigate the remedial impact of matching networks on the capacity degradation in such systems with respect to both uniform 2D angular power spectrum and measured wideband outdoor-toindoor channels. We find that the optimum narrowband multiport-matching network can perform poorly in the wideband case. For a modest 2.3% fractional bandwidth, the narrowband and wideband capacities (per unit bandwidth) can differ by as much as 60%. The multipath richness of the propagation scenario is also shown to have an important effect on the benefits that can be derived from more sophisticated matching networks which take into account mutual coupling in their designs.
Abstract #2707: Design and synthesis of dual PI3K/mTor inhibitors (2009)

Because the phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a crucial role in many aspects of cell growth and survival, inhibitors of the pathway offer great potential in the treatment of cancer. We have recently reported the discovery of potent and orally bioavailable pan inhibitors of PI3K, including the inhibitor GDC-0941. As part of our continued interest in the design of novel PI3K inhibitors, we embarked on a program to further probe key binding pockets in PI3K as well as increase structural diversity of our inhibitors. Through structure based design driven by crystallography in PI3Kgamma and systematic modification of our lead chemical series, new inhibitors that take advantage of alternative binding interactions in the PI3K ATP site have been identified. Because of the enhanced affinity of some new interactions, potent (IC50-p110a Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2707.
Facile Production of 2,5‐Furandicarboxylic Acid via Oxidation of Industrially Sourced Crude 5‐Hydroxymethylfurfural (2021)

The oxidation of 5-hydroxymethylfurfural (HMF) produces value-added chemicals such as 2,5-diformylfuran (DFF) and 2,5-furandicarboxylic acid (FDCA). In this work, FDCA production was achieved by oxidation of crude HMF solution containing around 45 % HMF and unwanted byproducts such as 5,5'-[oxy-bis(methylene)]bis-2-furfural (HMF dimer) and polymers. At optimized reaction conditions similar to the Mid-Century process, homogeneous oxidation of the crude HMF (up to 20 wt% in the feed) by Co/Mn/Br catalyst in acetic acid solution produced FDCA at >95 % yield. The solid FDCA product contained <4000 ppm 5-formyl-2-furancarboxylic acid (FFCA). Such high yields were observed because the impurities in crude HMF were also converted to FDCA, as confirmed by the facile oxidation of HMF dimer to FDCA under reaction conditions. The successful demonstration of crude HMF as feed, obviating the need for HMF purification, suggests potential for cost-effectively producing FDCA in existing terephthalic plants.
Epistatic and independent functions of Caspase-3 and Bcl-X L in developmental programmed cell death (2000)

The number of neurons in the mammalian brain is determined by a balance between cell proliferation and programmed cell death. Recent studies indicated that Bcl-X(L) prevents, whereas Caspase-3 mediates, cell death in the developing nervous system, but whether Bcl-X(L) directly blocks the apoptotic function of Caspase-3 in vivo is not known. To examine this question, we generated bcl-x/caspase-3 double mutants and found that caspase-3 deficiency abrogated the increased apoptosis of postmitotic neurons but not the increased hematopoietic cell death and embryonic lethality caused by the bcl-x mutation. In contrast, caspase-3, but not bcl-x, deficiency changed the normal incidence of neuronal progenitor cell apoptosis, consistent with the lack of expression of Bcl-X(L) in the proliferative population of the embryonic cortex. Thus, although Caspase-3 is epistatically downstream to Bcl-X(L) in postmitotic neurons, it independently regulates apoptosis of neuronal founder cells. Taken together, these results establish a role of programmed cell death in regulating the size of progenitor population in the central nervous system, a function that is distinct from the classic role of cell death in matching postmitotic neuronal population with postsynaptic targets.
ChemInform Abstract: L‐Nucleoside Analogues as Potential Antimalarials that Selectively Target Plasmodium falciparum Adenosine Deaminase. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hyperspectral sensor characteristics needed for coastal ocean science (2004)

The complexity of the coastal ocean, particularly when the bottom is visible, necessitates the use of hyperspectral imagery for remote measurement of bathymetry, bottom type, and water properties. This is in contrast to the open ocean where water column properties alone are of interest and for which the use of multispectral imagery is normally sufficient. The Remote Sensing Division of the NRL has had a program to develop hyperspectral imagery for coastal studies for more than 10 years. The Ocean Portable Hyperspectral Imager for Low-Light Spectroscopy (Ocean PHILLS), the most recent version of NRL's imaging spectrometer, is designed specifically for this application. It uses a thinned, backside-illuminated CCD for high sensitivity and an all-reflective spectrograph with a convex grating in an Offner configuration to produce a nearly distortion-free image. The sensors, which are constructed entirely from commercially available components, have been successfully deployed on numerous aircraft based experiments since 1999. After data collection is complete the data are geolocated, calibrated, atmospherically corrected and used for a variety of ocean and land products. In this presentation, we describe the instrument design, with emphasis on the specifications required for observing the coastal ocean. We also present examples of remote-sensing reflectance data obtained from the LEO-15 site in New Jersey that agree well with ground-truth measurements
Reciprocal Enhancement of Gene Expression and Viral Replication Between Human Cytomegalovirus and Human immunodeficiency Virus Type 1 (1990)

Biological interactions between human cytomegalovirus (HCMV) and the human immunodeficiency virus type 1 (HIV-1) were analysed in transfection and infection experiments, carried out in a human osteogenic sarcoma cell line (HOS) and in the same cell line chronically infected with HCMV (E155). When HOS and E155 cells were transfected with recombinant plasmids containing the HIV long terminal repeat (LTR) linked to the bacterial chloramphenicol acetyltransferase (CAT) gene, LTR-directed CAT expression was 20 times higher in E155 cells than in HOS cells. HOS cells co-infected with HCMV and HIV-1 showed enhanced production of the HIV-1 p24 antigen. In reciprocal experiments, an increase in HCMV immediate early gene expression was observed when HCMV-infected HOS cells and E155 cells were either transfected with a recombinant plasmid containing the HIV transactivator gene (pTAT), or when infected with HIV-1. DNA hybridization analysis of E155 and HCMV-infected HOS cells revealed higher levels of HCMV DNA in cells transfected with pTAT than in cells transfected with other non-specific recombinant plasmids. E155 cells transfected with pTAT also produced higher titres of infectious HCMV than control cultures of E155 cells transfected with other recombinant plasmids, including pMTAT carrying a mutant tat gene. The functional reciprocity in vitro between HCMV and HIV is discussed with respect to its possible implications for the clinical development of AIDS.
Synthetic cell-penetrating RAS-binding peptide for the treatment of KRAS-mutated cancer (2023)

Abstract The RAS-RAF-ERK1/2 pathway is a crucial target for anticancer drug development because of the high prevalence of ERK activation in human cancers. Mitogen-activated protein kinases (MAPKs) are pivotal intracellular cascade molecules critical in all eukaryotic cells for the recognition of and response to external stimuli. RAS plays an important role with respect to cell proliferation. MDA-MB-231 is a triple-negative breast cancer (TNBC) cell line carrying a G13D KRAS mutant; hence, it is resistant to drugs. Herein, the authors evaluated a synthetic cell-penetrating peptide that binds to RAS with high affinity (termed RAS-binding peptide, RBP) for the treatment of MDA-MB-231 cancer. In this study, MDA-MB-231 cells exhibited reduced proliferation since RBP inhibited the interaction between RAS and RAF. Moreover, a decrease in RBP-treated MDA-MB-231 cell migration and invasion were observed. The expression of phosphorylatedERK1/2 and RAF-bound RAS was reduced by RBP treatment. In chicken egg xenografts, RBP inhibited tumor growth and metastatic invasion. Infiltration of immune cells was evaluated via histopathological analysis, and reduction in the level of Ki-67, a proliferation marker in human tumor cells, was evident through immunohistochemical (IHC). Taken together, the peptide RBP was suggested to be a new therapeutic target in RAS-mutated cancer.
QCL seeded, ns-pulse, multi-line, CO2 laser oscillator for Laser-Produced-Plasma EUV source (2016)

This paper aims to describe in detail the operation principle and unique properties of the output of solid–state seeded CO2 laser, such as multi–line operation, excellent spectro-temporal stability and pulse waveform control.
Chemical Activation in Blood Serum and Human Cell Culture: Improved Ruthenium Complex for Catalytic Uncaging of Alloc‐Protected Amines (2017)

Chemical (as opposed to light-induced) activation of caged molecules is a rapidly advancing approach to trigger biological processes. We previously introduced the ruthenium-catalyzed release of allyloxycarbonyl (alloc)-protected amines in human cells. A restriction of this and all other methods is the limited lifetime of the catalyst, thus hampering meaningful applications. In this study, we addressed this problem with the development of a new generation of ruthenium complexes for the uncaging of alloc-protected amines with superior catalytic activity. Under biologically relevant conditions, we achieved a turnover number >300, a reaction rate of 580 m<sup>-1</sup> s<sup>-1</sup> , and we observed high activity in blood serum. Furthermore, alloc-protected doxorubicin, as an anticancer prodrug, could be activated in human cell culture and induced apoptosis with a single low dose (1 μm) of the new catalyst.
Thiolation of uridine carbon-2 restricts the motional dynamics of the transfer RNA wobble position nucleoside (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiolation of uridine carbon-2 restricts the motional dynamics of the transfer RNA wobble position nucleosidePaul F. Agris, Hanna Sierzputowska-Gracz, Wanda Smith, A. Malkiewicz, Elzbieta Sochacka, and Barbara NawrotCite this: J. Am. Chem. Soc. 1992, 114, 7, 2652–2656Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ja00033a044https://doi.org/10.1021/ja00033a044research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts