gebhart/patrepeval huggingface dataset:
Topological data analysis identified prognostically-distinct phenotypes in MitraClip patients (2022)

Abstract Background Topological data analysis (TDA) is the state-of-the-art unsupervised machine learning framework that can provide insight into the dataset and visualize condensed information via the topological network graph. This robust approach was never used to assess the heterogeneous MitraClip population. Purpose We aim to develop a TDA model that will identify prognostically-distinct phenogroups in MitraClip patients without a priori knowledge of the population and their outcomes. Method Patients who underwent MitraClip (June 2014-September 2020) at Mayo Clinic sites were identified from the institutional database for baseline and follow-up data. Thirteen variables were used for TDA. The topological network graph was created using the Python Scikit-TDA Kepler-Mapper package (v. 2.0.1), and clustering was performed at the graph level with Louvain's modularity method. Kaplan-Meier survival analysis was used to assess the all-cause mortality endpoint of each cluster identified in an unsupervised manner. The dataset with cluster labels was also used to train a Light Gradient Boosted Machine model, and SHapley Additive exPlanations (SHAP) analysis was applied to determine the feature importance. Results A total of 389 consecutive patients were included in the final analysis and two major clusters consisting of 384 patients were identified. The mean age was 80.3±8.7 years; 256 (65.8%) were male. The mean Society of Thoracic Surgeons Mitral Valve Replacement risk score was 9.6±6.9%. Fifty-five (14.5%) patients died during the mean follow duration (185 days). Kaplan-Meier analysis showed significant survival differences among the two clusters (HR: 2.38; 95% CI: 1.39–4.06, p=0.001; Figure 1). Clusters 1 (n=195) was associated with &amp;gt; mild residual mitral regurgitation and worse survival performance and was characterized with worse tricuspid regurgitation severity, a higher proportion of patients with atrial fibrillation/flutter, anterior leaflet prolapse, and mitral annular/leaflet calcification, as summarized in Table 1. Conclusion TDA can identify distinct phenotype clusters with prognostic significance in MitraClip patients based on mitral valve morphology and clinical risk factors. This simple model can facilitate clinical risk stratification for MitraClip patients regarding procedural success and survival performance. Funding Acknowledgement Type of funding sources: None.
Condyloma (2017)

Condyloma, from the Greek for “knuckle,” refers to papular genital wart-like growths. Condyloma lata refers to those lesions associated with secondary syphilis. Condyloma acuminatum and condylomata acuminata are caused by human papilloma virus (HPV) and are often referred to simply as condyloma, or genital warts. Most sexually active persons become infected with at least one strain of HPV sometime in their lifetime. An increased prevalence of HPV infection during pregnancy has been reported by several investigators, with the prevalence increasing as the gestational age increases and declining in the postpartum period. The diagnosis of condyloma can typically be made by visual inspection. Biopsy is indicated if the lesion is atypical, such as when the warts are pigmented, indurated, fixed, bleeding, or ulcerated. The use of synergistic therapy has normally been reserved for those with recurrent lesions or with a very high burden of condyloma.
Capacitative Calcium Entry Mechanism in Porcine Oocytes1 (2002)

The presence of the capacitative Ca(2+) entry mechanism was investigated in porcine oocytes. In vitro-matured oocytes were treated with thapsigargin in Ca(2+)-free medium for 3 h to deplete intracellular calcium stores. After restoring extracellular calcium, a large calcium influx was measured by using the calcium indicator dye fura-2, indicating capacitative Ca(2+) entry. A similar divalent cation influx could also be detected with the Mn(2+)-quench technique after inositol 1,4,5-triphosphate-induced Ca(2+) release. In both cases, lanthanum, the Ca(2+) permeable channel inhibitor, completely blocked the influx caused by store depletion. Heterologous expression of Drosophila trp in porcine oocytes enhanced the thapsigargin-induced Ca(2+) influx. Polymerase chain reaction cloning using primers that were designed based on mouse and human trp sequences revealed that porcine oocytes contain a trp homologue. As in other cell types, the capacitative Ca(2+) entry mechanism might help in refilling the intracellular stores after the release of Ca(2+) from the stores. Further investigation is needed to determine whether the trp channel serves as the capacitative Ca(2+) entry pathway in porcine oocytes or is simply activated by the endogenous capacitative Ca(2+) entry mechanism and thus contributes to Ca(2+) influx.
[2,4-Diisoleucine]-oxytocin. Analog of oxytocin with natriuretic and diuretic activities (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[2,4-Diisoleucine]-oxytocin. Analog of oxytocin with natriuretic and diuretic activitiesVictor J. Hruby, Vincent. Du Vigneaud, and Wah-Yip. ChanCite this: J. Med. Chem. 1970, 13, 2, 185–187Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/jm00296a004https://doi.org/10.1021/jm00296a004research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatial resolution enhancement in CT iterative reconstruction (2009)

Iterative reconstruction (IR) has recently been proposed to improve multiple aspects of image quality over conventional filtered backprojection (FBP) in X-ray computed tomography (CT). FBP reconstruction and its corresponding reconstruction kernels have been optimized for decades to provide the best possible image quality. IR does not have the notion of reconstruction kernels but uses other mechanisms to change the image resolution and image noise. This paper presents one computationally efficient technique to enhance the spatial resolution of IR images reconstructed from high resolution scans, based on the introduction of an enlarged voxel footprint in the forward model, combined with a band-suppression filter designed to eliminate any undesirable over- or under-shoot artifacts that may arise from the use of the enlarged voxels. The proposed technique achieves higher spatial resolution than high resolution FBP with significantly lower noise. Results are shown on both phantom and clinical patient data.
Cyclophosphamide type I hypersensitivity in systemic lupus erythematosus (2002)

Cyclophosphamide is an important immunosuppressive agent in the treatment of many rheumatic diseases. Urticaria and anaphylaxis to intravenous cyclophosphamide (i.v. CYC) have been reported in patients with haematological and solid organ malignancies. This is the first report in the rheumatology literature of a type I hypersensitivity reaction following monthly i.v. CYC. An 18-year-old girl with systemic lupus erythematosus (SLE) developed generalized urticaria (without concomitant angioedema or anaphylaxis) following i.v. CYC. She had previously developed life-threatening angioedema following a respiratory tract infection. She successfully completed regular pulse i.v. CYC with pre-medication with anti-histamine. In the absence of a severe type I hypersensitivity reaction and other suitable immunosuppressive agents, i.v. CYC may be safely continued with pre-medication and careful monitoring during each infusion.
Solid Composition of In1-xGaxAs Grown by the Halogen Transport Atomic Layer Epitaxy (1988)

The growth of In 1- x Ga x As by halogen transport atomic layer epitaxy (ALE) is described. The vapor-solid distribution relation for the group III elements is experimentally obtained. A model which assumes the Langmuir-type adsorption for the group III monochlorides is developed. It is shown that the solid composition grown by halogen transport ALE is determined by the competitive adsorption of GaCl and InCl on the substrate.
708-P: Complexity of Mealtime Insulin Dosing in Free-Living People with T1D: Novel Study with Varied Meal Macronutrient Content (2021)

Controlled in-patient studies indicate that high fat/protein meals require more insulin coverage than low fat meals with similar carbohydrate (CHO). However, it is unclear how dietary macronutrient content impacts on glycemic responses and insulin requirements in free-living T1D individuals. Adults with T1D (n=25) (mean±SD age 52±15 yrs, A1C 7.1±0.7%, 39% female) on insulin pump and continuous glucose monitoring (CGM) were enrolled in this 18-week duration study. Participants ate meals with specific macronutrient content (high glycemic index [GI], high fat [HGI-HF]; high GI, low fat [HGI-LF]; low GI, high fat [LGI-HF]; low GI, low fat [LGI-LF]). Meal, CGM, and insulin dosing data were reviewed by the study investigator, who provided dose optimization recommendations. Participants provided dosing and CGM data from 463 meals. Time-in-range (TIR) was similar for all meal types (table, p=0.72). LGI meals required significantly more insulin than HGI meals (p=0.01). Significantly more insulin per gram of CHO was used for LGI-HF vs. all other meal types (mean CHO-to-insulin ratio = 4.5 vs. 8.7 for HGI-HF, 7.6 for HGI-LF, and 5.5 for LGI-LF; p= 0.02). This exploratory study in free-living individuals with T1D highlights the complexity of mealtime insulin dosing, pointing to the need for bolus advisors that incorporate other dietary inputs in addition to CHO.View largeDownload slideView largeDownload slide DisclosureS. S. Edwards: Employee; Self; Eli Lilly and Company, Stock/Shareholder; Self; Eli Lilly and Company. W. Wang: Employee; Self; Eli Lilly and Company. E. Toschi: Consultant; Self; Medtronic. A. Atakov-castillo: None. R. Dewar: None. G. M. Steil: Consultant; Self; Abbott Diabetes, Eli Lilly and Company. H. Wolpert: Employee; Self; Eli Lilly and Company.FundingEli Lilly and Company
Lamellar diblock copolymer grain boundary morphology. 2. Scherk twist boundary energy calculations (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLamellar diblock copolymer grain boundary morphology. 2. Scherk twist boundary energy calculationsSamuel P. Gido and Edwin L. ThomasCite this: Macromolecules 1994, 27, 3, 849–861Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ma00081a034https://doi.org/10.1021/ma00081a034research-articleACS PublicationsRequest reuse permissionsArticle Views346Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proceedings of the 7th International Workshop on Exploiting Semantic Annotations in Information Retrieval (2014)

These proceedings contain the contributed papers of the Seventh Workshop on Exploiting Semantic Annotations in Information Retrieval (ESAIR 2014), held at CIKM 2014 in Shanghai, on November 7, 2014. After successful workshops at ECIR'08 in Glasgow, WSDM'09 in Barcelona, CIKM'10 in Toronto, CIKM'11 in Glasgow, CIKM'12 at Maui, and CIKM'13 in San Francisco, this year's workshop will remain to advance the general research agenda on this core problem, with an explicit focus on one of the most challenging aspects to address in the coming years. The main remaining challenge is on the user's side---the potential of rich document annotations can only be realized if matched by more articulate queries exploiting these powerful retrieval cues---and a more dynamic approach is emerging by exploiting new forms of query autosuggest. How can the query suggestion paradigm be used to encourage searcher to articulate longer queries, with concepts and relations linking their statement of request to existing semantic models? How do entity results and social network data in graph search change the classic division between searchers and information and lead to extreme personalization---are you the query? How to leverage transaction logs and recommendation, and how adaptive should we make the system? What are the privacy ramifications and the UX aspects---how to not creep out users?

These and other related questions will be discussed at this open format workshop -- the aim is to provide paths for further research to change the way we understand information access today!

The workshop will consist of three main parts: 
Two keynotes to help us frame the problem, and create a common understanding of the challenges: Peter Mika (Yahoo Labs) and Silviu-Petru Cucerzan (Microsoft Research).
A boaster and poster session with 11 papers selected by the program committee from 15 submissions (a 73% acceptance rate). Each paper was reviewed by at least two members of the program committee.
Breakout groups on different aspects of exploiting semantic annotations, with reports being discussed in the final session.
Stable Thiophosphate-Based All-Solid-State Lithium Batteries through Conformally Interfacial Nanocoating (2019)

All-solid-state lithium batteries (ASLBs) are promising for the next generation energy storage system with critical safety. Among various candidates, thiophosphate-based electrolytes have shown great promise because of their high ionic conductivity. However, the narrow operation voltage and poor compatibility with high voltage cathode materials impede their application in the development of high energy ASLBs. In this work, we studied the failure mechanism of Li6PS5Cl at high voltage through in situ Raman spectra and investigated the stability with high-voltage LiNi1/3Mn1/3Co1/3O2 (NMC) cathode. With a facile wet chemical approach, we coated a thin layer of amorphous Li0.35La0.5Sr0.05TiO3 (LLSTO) with 15–20 nm at the interface between NMC and Li6PS5Cl. We studied different coating parameters and optimized the coating thickness of the interface layers. Meanwhile, we studied the effect of NMC dimension to the ASLBs performance. We further conducted the first-principles thermodynamic calculations to understand the electrochemical stability between Li6PS5Cl and carbon, NMC, LLSTO, NMC/LLSTO. Attributed to the high stability of Li6PS5Cl with NMC/LLSTO and outstanding ionic conductivity of the LLSTO and Li6PS5Cl, at room temperature, the ASLBs exhibit outstanding capacity of 107 mAh g–1 and keep stable for 850 cycles with a high capacity retention of 91.5% at C/3 and voltage window 2.5–4.0 V (vs Li–In).
Liquid chromatography and electron‐capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry (2002)

Liquid separation methods in combination with electrospray mass spectrometry as well as the recently introduced fragmentation method electron capture dissociation (ECD) have become powerful tools in proteomics research. This paper presents the results of the first successful attempts to combine liquid chromatography (LC) and Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) with ECD in the analysis of a mixture of standard peptides and of a bovine serum albumin tryptic digest. A novel electron injection system provided conditions for ECD sufficient to yield extensive sequence information for the most abundant peptides in the mixtures on the time-scale of the chromatographic separation. The results suggest that LC/ECD-FTICRMS can be employed in the characterization of peptides in enzymatic digests of proteins or protein mixtures and identify and localize posttranslational modifications.
Model for reliable location of information in storage systems (2015)

In this work, the model of reliable location of information in systems of related nodes containing the physical disks is proposed. The hypotheses on the fault-tolerance of an individual node of system are formulated. On the basis of hypotheses, there are oered dependencies of speed and fault-tolerance of node on the density of its lling up. A system of ordinary dierential equations for the failure probability of the entire system is obtained. Examples of the dynamic information distribution in the system of two and three nodes are considered. Mathematics Subject Classication: 34B15, 37N40
Fluorescence melting curve analysis for the detection of the bcl-1/JH translocation in mantle cell lymphoma. (1999)

PCR amplification and product analysis for the detection of chromosomal translocations such as bcl-1/JH have traditionally been performed as a two-step process with separate amplification and product detection. PCR product detection has generally entailed gel electrophoresis, hybridization, or sequencing for confirmation of assay specificity. By using a microvolume fluorimeter integrated with a thermal cycler and the PCR compatible double-stranded DNA (dsDNA) binding dye SYBR Green I, we simultaneously amplified and detected bcl-1/JH translocation products by using rapid cycle PCR and fluorescence melting curve analysis. We analyzed DNA from 25 cases of lymphoproliferative disorders comprising 12 previously documented bcl-1/JH-positive mantle cell lymphomas, and 13 reactive lymphadenopathies. The samples were coded and analyzed in a blind manner for the presence of bcl-1/JH translocations by fluorescence melting curve analysis. The results of fluorescence analysis were compared with those of conventional PCR and gel electrophoresis. All of the 12 cases (100%) previously determined to be bcl-1/JH positive by conventional PCR analysis showed a characteristic sharp decrease in fluorescence at about 86 degrees C by melting curve analysis. For easier visualization of melting temperatures (Tm), fluorescence melting peaks were obtained by plotting the negative derivative of fluorescence over temperature (-dF/dT) versus temperature (T). Dilutional assays revealed that fluorescence melting curve analysis was more sensitive than conventional PCR and agarose gel electrophoresis with ultraviolet transillumination by as much as 40-fold. Our results indicate that nucleic acid amplification integrated with fluorescence melting curve analysis is a simple, reliable, sensitive, and rapid method for the detection of bcl-1/JH translocations. The feasibility of specific PCR product detection without electrophoresis or expensive fluorescently labeled probes makes this methodology attractive for studies in molecular pathology.
Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stressin amyloid β injection mouse model (2008)

Alzheimer's disease (AD), the most common cause of dementia in the elderly, is characterized by amyloid beta (Abeta)-containing plaques and neurofibrillary tangles, and synaptic and neuronal loss, along with progressive cognitive impairment. Although growing evidence suggests the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) on AD, this notion is still controversial. To evaluate the efficacy of statins for Abeta-induced cognitive impairment, we employed an Abeta injection model. Using this model, the present study demonstrated that pretreatment with fluvastatin, but not post-treatment just after Abeta exposure, prevented Abeta-induced memory impairment. We also observed that fluvastatin significantly decreased Abeta accumulation and oxidative stress after Abeta injection. Mice treated with simvastatin, but not fluvastatin, did not demonstrate the prevention of Abeta-induced memory impairment, and showed no significant decrease in oxidative stress. More importantly, fluvastatin significantly prevented the loss of neurons in the basal forebrain induced by Abeta. Overall, the present study demonstrated that fluvastatin significantly prevented memory impairment induced by Abeta. The beneficial effects of fluvastatin might be explained by the preservation of neurons through a significant decrease in Abeta accumulation and oxidative stress. In clinical practice, the timing of the start of fluvastatin treatment might be critical in achieving a beneficial effect on cognitive function.
Ultra shallow n/sup+//p junctions formed by out-diffusion from TiSi/sub 2/ with an amorphous silicon buffer layer (2005)

This paper presents a novel technology for ultra-shallow n/sup +/p junctions with low leakage current developed for the use of ULSI with scaled MOSFET's. The formation of shallow silicided junctions was investigated by implanting As into the TiSi/sub 2/ layer and the subsequent drive-in of the implanted arsenic into the Si substrate by a N/sub 2/ furnace. The TiSi/sub 2/ layer was formed by reaction of a deposited titanium with /spl alpha/ silicon. The junction quality is comparable to the conventional process (ITS). The major advantage of this process is more shallow junction depth than ITS's process. It is due to the depositied /spl alpha/-silicon film as a buffer layer that bulk-Si consumption during the silicidation process could be avoided.