gebhart/patrepeval huggingface dataset:
[The risk of grave evolution of tuberculosis in young children (under 2 years of age)]. (1977)

Between 1971 and 1972, 22% of all children under two years with tuberculosis presented with severe forms of the disease (meningitis, miliaria, caseous forms). In the period 1974-1975, although the number of cases in the group was reduced by half, the severe forms still represented 20,4% of the total. The risk of severe evolution of tuberculosis decreases rapidly, from 55--66% in the first months of life. to 14,2--15,5% at 1--2 years. The risk of death in children aged between 0 and 2 years with tuberculosis (all forms) was of 26,6--58,3% between 0 and 5 months but only 4,5--9,3% in the second year of life. The risk of death in young children with severe forms of tuberculosis was as high as 70--76,7% in those under the age of 6 months. The source of infection was identified in 72,4--76,4% of the severe cases. At the onset of the disease only 57,1% of the sources were known, while 42,9% were discovered later, by epidemiologic investigations. An analysis of cause for a severe evolution of tuberculosis in young children led to the conclusion that BCG vaccination should be performed systematically at birth, and that tuberculin skin test be carried out in all hospitalized children, regardless the diagnosis. They also recommend the use of anamnestic data concerning the possible existence of tuberculosis cases in the families of patients, performing of radiologic controls in young mothers etc. In the case of infants that come into a close contact at a very early age with parents, or other relatives suffering with tuberculosis, chemoprophylaxis with two associated tuberculostatics is indicated.
Tables S3-S4 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα<sup>WT</sup> and ERα<sup>MUT</sup> Breast Cancer (2023)

&lt;p&gt;Enriched GSEA pathways&lt;/p&gt;
Marine Cyanobacteria (2020)

Cyanobacteria are Gram-negative prokaryotes that can form morphologically diverse cellular and colonial structures as unicellular and filamentous strains. Synechococcus sp.PCC 7002 is a unicellular marine strain derived from oceanic ecosystem fish pens in Puerto Rico. It is naturally competent and all the bioengineered genetic constructs have been integrated into its genome by homologous recombination. Foreign gene expression was performed in Synechococcus sp. NKBG 15041c under pseudo-continuous culture. A well-established protocol has been developed for the transformation of Synechococcus sp. NKBG15041c by conjugation. The potential of Synechococcus sp. NKBG 15041c to be engineered for the production of a variety of metabolites has been investigated. In general, the pathway for the alkane biosynthesis and the α-olefin synthase pathway for α-olefin biosynthesis do not exist together in cyanobacteria.
Assessment of Ionosphere Spatial Decorrelation for Global Positioning System-Based Aircraft Landing Systems (2007)

Ground-based augmentations of the global positioning system demand guaranteed integrity to support aircraft precision approach and landing navigation. To quantitatively evaluate navigation integrity, an aircraft computes vertical and lateral protection levels as position-error bounds using the standard deviation of ionosphere spatial decorrelation. Thus, it is necessary to estimate typical ionospheric gradients for nominal days and to determine an appropriate upper bound to sufficiently cover the differential error due to the ionosphere spatial decorrelation. Both station-pair and time-step methods are used to assess the standard deviation of vertical (or zenith) ionospheric gradients (sigma(vig)). The station-pair method compares the simultaneous zenith delays from two different reference stations to a single satellite and observes the difference in delay across the known ionosphere pierce point separation. Because these ionosphere pierce point separations limit the observability of the station-pair method, the time-step method is also used to better understand ionospheric gradients at short distance scales (10-40 km). The time-step method compares the ionospheric delay of a single line of sight at one epoch with the delay for the same line of sight at another epoch a short time (a few to tens of minutes) later. This method has the advantage of removing interfrequency bias calibration errors on different satellites and receivers while possibly introducing an estimation error due to temporal ionospheric gradients. The results of this study demonstrate that typical values of sigma(vig) are on the order of 1-3 mm/,km for nonstormy ionospheric conditions. As a result, sigma(vig) of 4 mm/ k m is conservative enough to bound ionosphere spatial decorrelation for nominal days and still leave enough margin for more active days and for non-Gaussian tail behavior.
Silicon Photonic Switches Hybrid-Integrated With CMOS Drivers (2011)

This paper describes the design and measured performance of three different silicon photonic switches: a 2×2 switch, a 1×2 switch, and a 4×4 switch. All of the devices have been hybrid integrated with a corresponding custom 90-nm CMOS driver. The 2×2 switch is based on a wavelength-insensitive Mach-Zehnder interferometer (WIMZ) and the 1×2 is based on a two-ring resonator. The power dissipation of the 2×2 WIMZ switch was 2 mW from a 1.0-V supply, with measured transition time of 3.9 ns. The 4×4 switch, composed of six 2×2 Mach-Zehnder interferometer (MZI) switches was demonstrated to route 3×40 Gb/s WDM data with BER <; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> , with less than -10-dB crosstalk and 7-dB loss.
Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells (2014)

Highly pluripotent hESCs, cultured at 5% oxygen, demonstrate a greater amino acid turnover than hESCs cultured at 20% oxygen, or without FGF2. These data suggest that amino acid turnover could be used as a measure of the self-renewal capacity of hESCs.
Comparative Analysis of Student’s Academic Performance in Online and Face to Face Teaching of Biochemistry at HITEC-IMS Taxila (2022)

Background: During Covid pandemic the teaching/learning shifted from face to face to online. All institutions around the world developed learning environment for the students to facilitate distant learning. Subsequently assessments also followed online. After opening of the institutions on campus learning and assessments were carried out as usual. Objective: To see the effectiveness of teaching methods (online versus on campus) and to suggest improvement in both methods of teaching. Study Design: Retrospective comparative study Place and Duration of Study: Hitec-IMS, Taxila Pakistan from 1st September 2021 to 29th February 2022. Methodology: One hundred and ninety six academic performances of students in both the methods of learning were enrolled. Using purposive sampling technique, the EOB results of online and on campus were analyzed. Results: The better performance of student in term of summative assessments during online learning. Conclusion: Students found online environment better for learning and performing during examinations. Keywords: HITEC-IMS (Hitec Institute of Medical Sciences), NUMS (National University of Medical Sciences), EOB (end of block)
Stimulated Raman scattering and nonlinear focusing of high-power laser beams propagating in water (2015)

The physical processes associated with propagation of a high-power (power > critical power for self-focusing) laser beam in water include nonlinear focusing, stimulated Raman scattering (SRS), optical breakdown, and plasma formation. The interplay between nonlinear focusing and SRS is analyzed for cases where a significant portion of the pump power is channeled into the Stokes wave. Propagation simulations and an analytical model demonstrate that the Stokes wave can re-focus the pump wave after the power in the latter falls below the critical power. It is shown that this novel focusing mechanism is distinct from cross-phase focusing. The phenomenon of gain-focusing discussed here for propagation in water is expected to be of general occurrence applicable to any medium supporting nonlinear focusing and stimulated Raman scattering.
Tunable Bloch surface waves in anisotropic photonic crystals based on lithium niobate thin films (2016)

We present an original type of one-dimensional photonic crystal that includes one anisotropic layer made of a lithium niobate thin film. We demonstrate the versatility of such a device sustaining different Bloch surface waves (BSWs), depending on the orientation of the incident wave. By varying the orientation of the illumination of the multilayer, we measured an angle variation of 7° between the BSWs corresponding to the extraordinary and the ordinary index of the lithium niobate thin film. The potential of such a platform opens the way to novel tunable and active planar optics based on the electro- and thermo-optical properties of lithium niobate.
Octupolar chimeric compounds built from quinoline caged acetate moieties: a novel approach for 2-photon uncaging of biomolecules (2013)

The present study describes the synthesis and investigation of chimeric structures where 6-quinoline and 8-quinoline caging units are integrated in multipolar systems to yield “hybrid” molecular structures for two-photon uncaging. These systems were demonstrated to exhibit strikingly enhanced (up to more than 2 orders of magnitude larger for octupolar derivatives) two-photon absorption responses in the NIR region compared to common caging groups. Whereas the quadrupolar compound shows the lowest two-photon uncaging cross-section (δu), octupolar chimeric derivatives display one-order larger δu values than their dipolar analogues. This opens a promising route for the design of efficient octupolar type derivatives for two-photon uncaging of biomolecules.
Small‐diameter tunneling in difficult ground – Analysis of TBM performance in hard rock (2023)

Abstract Small‐diameter tunneling in hard rock is increasingly widespread due to the need for new and longer utility tunnels comprising sewer, stormwater, freshwater, or hydropower as well as cable tunnels and casings for pipelines transporting gas or hydrogen. Utility tunnels have to deal with a wide range of geological settings, like small overburden, weathered rock, rock–soil transitions, as well as fractured or intact hard rock with high strength and abrasivity. A database has been created including 35 hard rock projects with diameters between 1 and 5 m as well as more than 70,000 m of tunnel alignments, with a median drive length of less than 500 m. Challenges in creating it and some early interpretations based on the contents of the database are presented. Details about an exemplary pipe jacking project in basement rocks in Brittany, France, are given. The large variety in this small‐diameter range in hard rock includes different TBM types, cutterhead designs, cutter types, and geotechnical conditions. Potential pitfalls in small‐diameter TBM data analysis are shown and general drive parameter trends and penetration prediction approaches are presented and set in relation to the geotechnical conditions. Our analysis shows that difficult ground conditions do not only incorporate rocks with very high strength, but also generally weak rocks like schist or limestone could be responsible for low penetration rates and high thrust forces.
Preparation of Ultrafine Ruthenium Oxide Particles with Ammonium Hydrogencarbonate (1997)

Ruthenium oxidc precuIsols wele prcpared from ruthenium chloride in aqueous solutionThe addition of ammonium hydrogcncarbonate to thc ruthcnium chloride aqucous solution results in complctc pripitation ofthc Iuthenium oxidc prccursolsThe solution pH value can be kcpt Qostant around neutrality bccause the acidic products are neutralizod with ammonium hydrogencarbonate to ogaseous carbon dioxideThe ncutlality of the solution should be importantor the contuancc
Reversible Permeabilization of Plasma Membranes With Engineered Nano-Scale Switchable Pores (1996)

Abstract By using an engineered, self-assembling, proteinaceous, nano-scale pore equipped with a metal-actuated switch, a technique to deliberately and reversibly permeabilize the plasma membrane to small molecules (∼1000 Da) has been developed. We have demonstrated the dose dependent permeabilization of fibroblasts by 2 nm pores designed to be blocked and unblocked by the addition and removal of μM concentrations of Zn2+. Further, we have shown that the activity of the switch allows permeabilized cells to maintain viability following unconstrained flux of small molecules. This ability to control the transmembrane influx and efflux of molecules and thereby vary the intracellular environment yet maintain cell viability will impact an array of biological and medical problems.
Experimental Evaluation of the Time and Frequency Crosstalk Dependency in a 7-Core Multi-Core Fiber (2015)

We experimentally evaluate the time-varying crosstalk frequency response of a multicore fiber. Our findings suggest that dynamically adaptive transmission would be able to exploit this behavior, to improve the performance of crosstalk-limited links.
Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA‐Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines (2020)

Spatially localized microbubble cavitation by ultrasound offers an effective means of altering permeability of natural barriers (i.e. blood vessel and cell membrane) in favor of nanomaterials accumulation in the target site. In this study, a clinically relevant, minimally invasive ultrasound guided therapeutic approach is investigated for targeted delivery of anticancer microRNA loaded PLGA-<i>b</i>-PEG nanoparticles to spontaneous hepatocellular neoplasia in a canine model. Quantitative assessment of the delivered microRNAs revealed prominent and consistent increase in miRNAs levels (1.5-to 2.3-fold increase (p<0.001)) in ultrasound treated tumor regions compared to untreated control regions. Immunohistology of ultrasound treated tumor tissue presented a clear evidence for higher amount of nanoparticles extravasation from the blood vessels. A distinct pattern of cytokine expression supporting CD8+ T cells mediated "cold-to-hot" tumor transition was evident in all patients. On the outset, proposed platform can enhance delivery of miRNA-loaded nanoparticles to deep seated tumors in large animals to enhance chemotherapy.
Novel filter bank-based cooperative spectrum sensing under practical challenges for beyond 5G cognitive radios (2021)

Abstract Cognitive radio (CR) technology with dynamic spectrum management capabilities is widely advocated for utilizing effectively the unused spectrum resources. The main idea behind CR technology is to trigger secondary communications to utilize the unused spectral resources. However, CR technology heavily relies on spectrum sensing techniques which are applied to estimate the presence of primary user (PU) signals. This paper firstly focuses on novel analysis filter bank (AFB) and FFT-based cooperative spectrum sensing (CSS) techniques as conceptually and computationally simplified CSS methods based on subband energies to detect the spectral holes in the interesting part of the radio spectrum. To counteract the practical wireless channel effects, collaborative subband-based approaches of PU signal sensing are studied. CSS has the capability to relax the problems of both hidden nodes and fading multipath channels. FFT- and AFB-based receiver side sensing methods are applied for OFDM waveform and filter bank-based multicarrier (FBMC) waveform, respectively, the latter one as a candidate beyond-OFDM/beyond-5G scheme. Subband energies are then applied for enhanced energy detection (ED)-based CSS methods that are proposed in the context of wideband, multimode sensing. Our first case study focuses on sensing potential spectral gaps close to relatively strong primary users, considering also the effects of spectral regrowth due to power amplifier nonlinearities. The study shows that AFB-based CSS with FBMC waveform is able to improve the performance significantly. Our second case study considers a novel maximum–minimum energy detector (Max–Min ED)-based CSS. The proposed method is expected to effectively overcome the issue of noise uncertainty (NU) with remarkably lower implementation complexity compared to the existing methods. The developed algorithm with reduced complexity, enhanced detection performance, and improved reliability is presented as an attractive solution to counteract the practical wireless channel effects under low SNR. Closed-form analytic expressions are derived for the threshold and false alarm and detection probabilities considering frequency selective scenarios under NU. The validity of the novel expressions is justified through comparisons with respective results from computer simulations.
Post-Source Decay (PSD) (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Amplification of chromosomal DNA in situ (2023)

Amplification of chromosomal DNA in situ to increase the amount of DNA associated with a chromosome or chromosome region is described. The amplification of chromosomal DNA in situ provides for the synthesis of Fluorescence in situ Hybridization (FISH) painting probes from single dissected chromosome fragments, the production of cDNA libraries from low copy mRNAs and improved in Comparative Genomic Hybridization (CGH) procedures.
Construction and evaluation of type III secretion system mutants of the catfish pathogen Edwardsiella piscicida (2018)

Catfish is the largest aquaculture industry in the United States. Edwardsiellosis is considered one of the most significant problems affecting this industry. Edwardsiella piscicida is a newly described species within the genus Edwardsiella, and it was previously classified as Edwardsiella tarda. It causes gastrointestinal septicaemia, primarily in summer months, in farmed channel catfish in the south-eastern United States. In the current study, we adapted gene deletion methods used for Edwardsiella to E. piscicida strain C07-087, which was isolated from a disease outbreak in a catfish production pond. Four genes encoding structural proteins in the type III secretion system (T3SS) apparatus of E. piscicida were deleted by homologous recombination and allelic exchange to produce in-frame deletion mutants (EpΔssaV, EpΔesaM, EpΔyscR and EpΔescT). The mutants were phenotypically characterized, and virulence and vaccine efficacy were evaluated. Three of the mutants, EpΔssaV, EpΔyscR and EpΔesaM, were significantly attenuated compared to the parent strain (p < .05), but EpΔescT strain was not. Vaccination of catfish with the four mutant strains (EpΔssaV, EpΔesaM, EpΔyscR and EpΔescT) provided significant protection when subsequently challenged with wild-type strain. In conclusion, we report methods for gene deletion in E. piscicida and development of vaccine candidates derived from a virulent catfish isolate.
Generation and functional characterization of mouse monocyte-derived dendritic cells (1999)

Dendritic cells (DC) are potent antigen-presenting cells with the unique capacity to initiate primary immune responses. As a result, DC are currently used in clinical studies to induce immunity against infectious disease and malignant cells. However, multiple DC subsets exist and it has been suggested that the type of DC may affect the immune response induced. The vast majority of DC used in experimental mouse tumor models is derived from bone marrow progenitors. In contrast, most in vitro as well as in vivo human studies involve the use of DC generated from adherent peripheral blood-derived monocytes in the presence of GM-CSF and IL-4. In the current report, we describe for the first time the generation and characterization of mouse monocyte-derived DC (MODC). The results indicate that mouse MODC display similar morphology, phenotype and immunostimulatory activity as compared to bone marrow-derived DC. Both DC subsets were able to efficiently take up and subsequently cross-present protein antigen to cytotoxic T cells. Moreover, we demonstrate that vaccination with peptide-loaded MODC mediates induction of tumor-reactive immunity in vivo. The isolation and characterization of mouse MODC will provide a valuable research tool to investigate fundamental aspects of DC biology and which DC subsets are most suitable to induce anti-tumor immunity.
Synthesis and characterization of a high temperature thermosetting polyimide oligomer derived from a non-toxic, sustainable bisaniline (2017)

A high temperature, hydrophobic thermosetting polyimide oligomer has been prepared from a non-toxic, bio-based bisaniline derived from <italic>p</italic>-cymene.
Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019)

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.
Configurable fine-grain protection for multicore processor virtualization (2012)

Multicore architectures, with their abundant on-chip resources, are effectively collections of systems-on-a-chip. The protection system for these architectures must support multiple concurrently executing operating systems (OSes) with different needs, and manage and protect the hardware's novel communication mechanisms and hardware features. Traditional protection systems are insufficient; they protect supervisor from user code, but typically do not protect one system from another, and only support fixed assignment of resources to protection levels. In this paper, we propose an alternative to traditional protection systems which we call configurable fine-grain protection (CFP). CFP enables the dynamic assignment of in-core resources to protection levels. We investigate how CFP enables different system software stacks to utilize the same configurable protection hardware, and how differing OSes can execute at the same time on a multicore processor with CFP. As illustration, we describe an implementation of CFP in a commercial multicore, the TILE64 processor.