gebhart/patrepeval huggingface dataset:
Design, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory response (2020)

The synthesis and characterization of the full family of 11 pyrazoles were performed by means of UV–Vis, FTIR, 1H NMR, 13C NMR, two-dimensional NMR experiments and DFT simulations. As pyrazoles are known for showing diverse biological actions, they were also tested in the NCI-60 cancer cell line panel, showing moderate to good activity against different cell lines. Furthermore, the anti-proinflammatory activity test of a set of pyrazoles of the form (E)-4-((4-bromophenyl)diazenyl)-3,5-dimethyl-1-R-phenyl-1H-pyrazole was performed, this is based on the study of the blockage of the increase in intracellular [Ca2+] observed in response to platelet-activating factor (PAF) treatment of four pyrazoles (i.e. 6, 8, 9 and 10), which successfully displayed [Ca2+] channel inhibition. Therefore, the obtained intracellular [Ca2+] signal results indicate that the pyrazole family characterized in this study, in particular compounds 6 and 10, are potent blockers of the PAF-initiated Ca2+ signaling that mediates the hyperpermeability typically observed during the development of inflammation.
Nerve growth factor receptor immunoreactivity is transiently associated with the subplate neurons of the mammalian cerebral cortex. (1990)

Nerve growth factor and its receptor (NGFR) are known to be present in diverse embryonic and neonatal central nervous system tissues, including the cerebral cortex. However, the identity of the cortical cells expressing NGFR immunoreactivity has not been established. We have used immunolabeling coupled with [3H]thymidine autoradiography to identify such cells in ferret and cat brain. Polyclonal antibodies raised against a synthetic peptide corresponding to a conserved amino acid sequence of the NGFR were used for this purpose. Western (immunologic) blot analyses show that these antibodies specifically recognize NGFR and precursor proteins. In both species, NGFR immunoreactivity is primarily associated with the early generated and transient subplate neuron population of the developing neocortex, as indicated by the following evidence: the immunoreactive cells (i) are located directly beneath the developing cortical plate, (ii) frequently have the inverted pyramid shape characteristic of subplate neurons, and (iii) can be labeled by an injection of [3H]thymidine on embryonic day (E) 28, a time when only subplate neurons are being generated. Intense NGFR immunostaining is seen on the cell bodies of these neurons as early as E30, several days after their last round of cell division, and this immunostaining remains strong for approximately 3 weeks. The NGFR immunoreactivity begins to decline around E52 and has disappeared from the region altogether by E60, at which time subplate neurons begin to die. The cellular localization and timing of expression suggest that the NGFR may play a role in the maintenance of subplate neurons and in the maturation of the cerebral cortex.
Optical coherence tomography angiography characteristics of choroidal neovascularization requiring varied dosing frequencies in treat-and-extend management: An analysis of the AVATAR study (2019)

The combination of CNV sparing the foveal center with higher circularity may suggest a clinically inactive CNV following initial anti-VEGF therapy. We found minimal distinguishing OCTA characteristics between those eyes that required ongoing therapy with the treat-and-extend regimen. More research is needed to identify specific CNV characteristics on OCTA that may become a useful tool for the management of NVAMD and timing of treatment.
Abstract 2296: IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition (2014)

Abstract Mutations of IDH1 and IDH2 which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors including acute myeloid leukemia (AML). Recent studies have shown that expression of the IDH mutant enzymes results in high levels of 2HG and a block in cellular differentiation that can be reversed with IDH-mutant specific small molecule inhibitors. To further understand the role of IDH mutations in cancer, we conducted mechanistic studies in the TF-1 IDH2 R140Q erythroleukemia model system and found that IDH2 mutant expression caused both histone and genomic DNA methylation changes that can be reversed when IDH2 mutant activity is inhibited. Specifically, histone hypermethylation is rapidly reversed within days whereas reversal of DNA hypermethylation proceeds in a progressive manner over the course of weeks. Pathway enrichment analysis revealed several pathways involved in tumorigenesis of leukemia and lymphoma, indicating a selective modulation of relevant cancer genes by IDH mutations. As methylation of DNA and histones is closely linked to mRNA expression and differentiation, these results indicate that IDH2 mutant inhibition may function as a cancer therapy via histone and DNA demethylation at genes involved in differentiation and tumorigenesis. Citation Format: Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen. IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2296. doi:10.1158/1538-7445.AM2014-2296
Improved cardiac sodium MR imaging by density‐weighted phase‐encoding (2004)

This new method for human cardiac sodium imaging provides high image quality combined with optimal sensitivity and thus may improve the clinical applicability of 23Na cardiac MRI.
Strong Modulation of Infrared Light using Graphene Integration with Plasmonic Fano-Resonant Metasurfaces (2014)

Plasmonic metasurfaces represent a promising platform for enhancing light-matter interaction. Active control of the optical response of metasurfaces is desirable for applications such as beam-steering, modulators and switches, biochemical sensors, and compact optoelectronic devices. Here we use a plasmonic metasurface with two Fano resonances to enhance the interaction of infrared light with electrically controllable single layer graphene. It is experimentally shown that the narrow spectral width of these resonances, combined with strong light/graphene coupling, enables reflectivity modulation by nearly an order of magnitude leading to a modulation depth as large as 90%. . Numerical simulations demonstrate the possibility of strong active modulation of the phase of the reflected light while keeping the reflectivity nearly constant, thereby paving the way to tunable infrared lensing and beam steering
The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day (2018)

The new modifications introduced in the T1D simulator allow to extend its domain of validity from "single-meal" to "single-day" scenarios, thus enabling a more realistic framework for in silico testing of advanced diabetes technologies including glucose sensors, new insulin molecules and artificial pancreas.
A mistuning-tolerant and controllable power supply for roadway wireless power systems (2016)

Inductive Power Transfer power supplies for electric vehicles (EV) charging in dynamic applications need to tolerate large variations in coupling and tuning with varying loads. This paper investigates the use of a buck converter to regulate the input voltage to a fixed frequency unidirectional switch push-pull converter to meet the requirements of dynamic charging. The presented circuit is optimised to remove some of the additional components introduced. A mathematical model is presented which shows the circuit is capable of operating while extremely mistuned in both the inductive and capacitive regions while maintaining low THD. A controller design is also presented allowing constant primary current operation, safe start up and operation under no load conditions. The results from a 1 kW prototype tolerating a 34% change in primary inductance is also presented.
Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes (2000)

A serious complication in hemophilia care is the development of factor VIII (FVIII) neutralizing antibodies (inhibitors). The authors used V gene phage display technology to define human anti-FVIII antibodies at the molecular level. The IgG4-specific, variable, heavy-chain gene repertoire of a patient with acquired hemophilia was combined with a nonimmune, variable, light-chain gene repertoire for display as single-chain variable domain antibody fragments (scFv) on filamentous phage. ScFv were selected by 4 rounds of panning on immobilized FVIII light chain. Sequence analysis revealed that isolated scFv were characterized by V(H) domains encoded by germline genes DP-10, DP-14, and DP-88, all belonging to the V(H)1 gene family. All clones displayed extensive hypermutation and were characterized by unusually long CDR3 sequences of 20 to 23 amino acids. Immunoprecipitation revealed that all scFv examined bound to the C2 domain of FVIII. Furthermore, isolated scFv competed with an inhibitory murine monoclonal antibody for binding to the C2 domain. Even though scFv bound FVIII with high affinity, they did not inhibit FVIII activity. Interestingly, the addition of scFv diminished the inhibitory potential of patient-derived antibodies with C2 domain specificity. These results suggest that the epitope of a significant portion of anti-C2 domain antibodies overlaps with that of the scFv isolated in this study. (Blood. 2000;95:558-563)
Interstellar dust in the BOOMERanG maps (2002)

Interstellar dust (ISD) emission is present in the mm-wave maps obtained by the BOOMERanG experiment at intermediate and high Galactic latitudes. We find that, while being sub-dominant at the lower frequencies (90, 150, 240 GHz), thermal emission from ISD is dominant at 410 GHz, and is well correlated with the IRAS map at 100 μm. We find also that the angular power spectrum of ISD fluctuations at 410 GHz is a power law, and its level is negligible with respect to the angular power spectrum of the Cosmic Microwave Background (CMB) at 90 and 150 GHz.
Platinum-Nickel Nanotubes Array as Cathode for PEMFC (2019)

Pt-based catalysts such as Pt-Co, Pt-Cu, Pt-Ni etc. have been shown to exhibit higher oxygen reduction reaction (ORR) activity than platinum for Proton Exchange Membrane Fuel Cells. This paper describes the synthesis of a new carbon-free structure of electrodes made of vertically aligned PtNi Nanotubes. The process is based on an electrochemistry route of Ni electrodeposition inside nonporous alumina mold, followed by a step of controlled galvanic displacement, annealing and acid treatment leading to the formation of nanotubes. The latter are transferred onto a Nafion® membrane using an optimized hot pressing process.
Accuracy of Ultrasound Measurements for Skull Bone Thickness Using Coded Signals (2009)

The knowledge of skull bone thickness would be helpful for a great variety of surgical interventions of the head. Ultrasound (US) can offer this information intraoperatively in real time. A-mode US measurements of skull bone thickness were performed with different pulse characteristics: 1) in water and 2) by directly coupling a 2.25-MHz US transducer integrated in a handpiece with a soft delay line using coded excitation (CE) (SonoPointer). Mechanical measurements by calipers served as controls. The specimen were 16 nonselected human cadaveric skull bones preserved with formaldehyde. The average difference between the bone thickness measured by the SonoPointer and the mechanical control measurements was 0.04 +/- 0.62 mm. The 95% limits of agreement between the two methods were -1.18 and 1.25 mm. However, even the gold standard of two repeated caliper measurements had limits of agreement of -0.4 and 0.42 mm. Using a standard US pulse in water, only 62.5% sample points were measurable, whereas the SonoPointer produced the thickness measurement in 97.9% of points. CE proved to be superior to single burst or needle US pulses. A-mode US measurements of skull bone thickness using the SonoPointer are feasible. It may provide valuable information on skull bone thickness, e.g., for osteosynthesis, calvarial split bone harvesting, implantation of hearing devices, osseointegrated titanium fixtures, and skull base surgery.
Adaptive Equalization Techniques for Digital Video Recording Systems (1988)

An adaptive automatic equalizer applicable to high-rate data recording systems such as digital VTRs is proposed. This equalizer is constructed on the nonlinear equalization technique called linear cancellation and on probabilistic decoding techniques. Two particular advantages are noted: that equalization with logical error correction is performed and that the variable part of the equalizer can be composed solely of digital circuits. It has been confirmed that sufficient eye-pattern opening can be achieved using this equalizer at an operation speed of 46 Mbits/sec.
P753 Vedolizumab trough levels during induction in IBD patients: A longitudinal observational retrospective study (2018)

Vedolizumab (VDZ) is effective for the treatment of ulcerative colitis (UC) or Crohn’s disease (CD). Few real-world experience data are available on the relevance of measuring trough levels (TLs) early on to predict loss of response in patients treated with VDZ. Our objective was to evaluate VDZ TLs early on at induction In total, 86 IBD patients (45 CD, 32 UC, 9 IBD unclassified) have been treated with VDZ. 400 samples were prospectively collected from September 2015 to August 2017 and measured retrospectively by Ridascreen VDZ ELISA in parallel with clinical, biological and endoscopic data. Induction analyses include second and third infusion; optional dose at week 10 not included. Treatment failure was defined by the need to optimise VDZ and/or to swap because of active disease. Sustained response was defined by clinical response without need of optimisation. Statistical analyses were performed using the Student t-test. Results were expressed as mean ± standard error. 34% of patients (n = 29/86) stopped VDZ because of treatment failure during maintenance. The mean duration of VDZ treatment is shorter in patients experiencing treatment failure (145 days25 days) than patients with sustained response (263 days ± 27, p = 0.004). At the third infusion (week 6), the sustained response group had higher TLs (38.1 mg/ml ± 4.7) than the failure group (24.7 mg/ml ± 3.1) (p = 0.03) (Figure 1). Sustained Response and Treatment Failure groups at third induction (week 6) but not at the second infusion (week 2) (36.3 mg/ml ± 2.35 vs. 29.7 mg/ml ± 2.94, p = 0.65). At induction, patients previously treated with anti-TNF had significant lower TLs (30.4 mg/ml ± 1.75) compared with anti-TNF naïve patients (35.5 mg/ml ± 2.3, p = 0.04) (Figure 2) Anti-TNF naïve and Anti-TNF previously exposed groups (week 2 and 6, optional dose at week 10 not included) There was significant more VDZ failure in patients previously treated with anti-TNF compared with anti-TNF naïve patients (24/63VS2/23, p = 0.008). Finally, 31% of the cohort (n = 27/86) had combo therapy with immunomodulators (IMM) but no difference was observed in terms of TLs at induction (29.9 mg/ml ± 2.7g with IMM vs. 31.7 mg/ml ± 1.7 without IMM, p = 0.5). There was not more VDZ failure without IMM than with IMM (18/59 VS. 11/27, p = 0.46) This study suggests that patients who lose response to VDZ during maintenance have lower VDZ TLs at induction. VDZ TLs at week 6 (3nd infusion) seem to be the most indicative time point. The presence of IMM does not seem to impact TLs at induction or to generate a reduction of VDZ failure
Noble metal-free bifunctional oxygen evolution and oxygen reduction acidic media electro-catalysts (2016)

Identification of low cost, highly active, durable completely noble metal-free electro-catalyst for oxygen reduction reaction (ORR) in proton exchange membrane (PEM) fuel cells, oxygen evolution reaction (OER) in PEM based water electrolysis and metal air batteries remains one of the major unfulfilled scientific and technological challenges of PEM based acid mediated electro-catalysts. In contrast, several non-noble metals based electro-catalysts have been identified for alkaline and neutral medium water electrolysis and fuel cells. Herein we report for the very first time, F doped Cu1.5Mn1.5O4, identified by exploiting theoretical first principles calculations for ORR and OER in PEM based systems. The identified novel noble metal-free electro-catalyst showed similar onset potential (1.43 V for OER and 1 V for ORR vs RHE) to that of IrO2 and Pt/C, respectively. The system also displayed excellent electrochemical activity comparable to IrO2 for OER and Pt/C for ORR, respectively, along with remarkable long term stability for 6000 cycles in acidic media validating theory, while also displaying superior methanol tolerance and yielding recommended power densities in full cell configurations.
Low Power All-Optical Switching in a Gallium Arsenide Photonic Molecule (2015)

We demonstrate low power all-optical switching in a gallium arsenide (GaAs) photonic molecule with resonances near the material band edge. The enhanced nonlinear effects in this spectral region result in a low estimated switching energy of a few femtojoules with 45% transmission contrast.
Supplementary Figure 3 from A Human Breast Cell Model of Preinvasive to Invasive Transition (2023)

Supplementary Figure 3 from A Human Breast Cell Model of Preinvasive to Invasive Transition
Development of a Three-Element Beam Steering Antenna for Bearing Determination Onboard a UAV Capable of GNSS RFI Localization (2017)

Localization of radio frequency interference (RFI) sources requires some method of measuring the interference signal. A technique used for this problem in the past, coupled with an unmanned aerial vehicle (UAV), is using a collection of signal strength measurements to determine bearing to the source. This paper focuses on the improvements from a physical rotation based system to an electronic rotation system. Previously 30 seconds was required to collect a set of signal strengths to use for a bearing and now, with a beam steering antenna, that rotation time is reduced to just over 0.5 seconds. Here, the improvements to the measurement sensor onboard a UAV for RFI localization are detailed. Using the same philosophy to get bearing from a collection of signal strength measurements, these improvements move from a physical rotation to an electronic rotation through the development of a small and compact three-element beam steering antenna. Using this type of antenna allows for signal strength measurements at 500Hz and in motion and therefore enables a much higher observation rate, on the order of 2Hz, enabling the use of different navigation and path planning algorithms that could lead to much faster and more efficient localization. This paper describes the design, development and testing of the beam steering antenna itself, the algorithms for controlling the beam steering to be able to get the best observation performance, and finally demonstrates the performance of the antenna during live interference exercises at Edwards Airforce Base (AFB).
Indium selenide nanowire phase-change memory (2007)

Nonvolatile memory device using indium selenide nanowire as programmable resistive element was fabricated and its resistive switching property was studied as functions of electrical pulse width and voltage magnitude. The nanowire memory can be repeatedly switched between high-resistance (∼1011Ω) and low-resistance (∼6×105Ω) states which are attributed to amorphous and crystalline states, respectively. Once set to a specific state, the nanowire resistance is stable as measured at voltages up to 2V. This observation suggests that the nanowire can be programed into two distinct states with a large on-off resistance ratio of ∼105 with significant potential for nonvolatile information storage.
A comparative performance analysis of a DDR-SDRAM, a D-RDRAM, and a DDR-FCRAM using a POPeye simulator (2002)

We implemented POPeye (Probe of Performance+eye), a system analysis simulator to evaluate DRAM performance in a personal computer environment. When running any real-life application programs such as Microsoft Office and Paint Shop Pro on Windows OS, POPeye simulates detailed transactions between a CPU and a memory system. Using this tool, we comparatively analyzed the performance of a DDR-SDRAM, a D-RDRAM, and a DDR-FCRAM.
Nucleic acids encoding plant glutamine phenylpyruvate transaminase (GPT) and uses thereof (2023)

Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism.
Aerosol reactor design: effect of reactor type and process parameters on product aerosol characteristics (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAerosol reactor design: effect of reactor type and process parameters on product aerosol characteristicsSotiris E. Pratsinis, Toivo T. Kodas, Milorad P. Dudukovic, and Sheldon K. FriedlanderCite this: Ind. Eng. Chem. Process Des. Dev. 1986, 25, 3, 634–642Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/i200034a007https://doi.org/10.1021/i200034a007research-articleACS PublicationsRequest reuse permissionsArticle Views452Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Supplementary Figures 1 through 7 from LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms (2023)

&lt;p&gt;This file contains all supplementary figures: Figure S1. LY2606368 is an ATP competitive inhibitor of CHK1. Figure S2. LY2606368 is a potent catalytic and phenotypic inhibitor of CHK1. Figure S3. LY2606368 inhibits DNA damage-dependent autophosphorylation of CHK2. Figure S4. LY2606368 does not inhibit RSK activity in cells Figure S5. Treatment of Calu-6 lung cancer cells with LY2606368 results in rapid accumulation of DNA strand breaks in early S-phase. Figure S6. Timelapse photomicroscopy of LY2606368 treated HeLa cells confirms that S-phase transit is required for aberrant mitosis and cell death. Figure S7. Staurosporine causes rapid appearance of apoptotic TUNEL staining, but not H2AX serine 139 phosphorylation.&lt;/p&gt;