gebhart/patrepeval huggingface dataset:
SKATE: A Natural Language Interface for Encoding Structured Knowledge (2020)

In Natural Language (NL) applications, there is often a mismatch between what the NL interface is capable of interpreting and what a lay user knows how to express. This work describes a novel natural language interface that reduces this mismatch by refining natural language input through successive, automatically generated semi-structured templates. In this paper we describe how our approach, called SKATE, uses a neural semantic parser to parse NL input and suggest semi-structured templates, which are recursively filled to produce fully structured interpretations. We also show how SKATE integrates with a neural rule-generation model to interactively suggest and acquire commonsense knowledge. We provide a preliminary coverage analysis of SKATE for the task of story understanding, and then describe a current business use-case of the tool in a specific domain: COVID-19 policy design.
Rate-Splitting Multiple Access With Finite Blocklength for Short-Packet and Low-Latency Downlink Communications (2022)

Rate-Splitting Multiple Access (RSMA) is an emerging flexible and powerful multiple access for downlink multi-antenna networks. In this paper, we introduce the concept of RSMA into short-packet downlink communications. We design optimal linear precoders that maximize the sum rate with Finite Blocklength (FBL) constraints. The relations between the sum rate and blocklength of RSMA are investigated for a wide range of network loads and user deployments. Numerical results demonstrate that RSMA can achieve the same transmission rate as Non-Orthogonal Multiple Access (NOMA) and Space Division Multiple Access (SDMA) with smaller blocklengths (and therefore lower latency), especially in overloaded multi-antenna networks. Hence, we conclude that RSMA is a promising multiple access for low-latency communications.
Data from Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Mutations of the human type Iα regulatory subunit (RIα) of cyclic AMP-dependent protein kinase (PKA; &lt;i&gt;PRKAR1A&lt;/i&gt;) lead to altered kinase activity, primary pigmented nodular adrenocortical disease, and tumors of the thyroid and other tissues. To bypass the early embryonic lethality of &lt;i&gt;Prkar1a&lt;/i&gt;&lt;sup&gt;−/−&lt;/sup&gt; mice, we established transgenic mice carrying an antisense transgene for &lt;i&gt;Prkar1a&lt;/i&gt; exon 2 (X2AS) under the control of a tetracycline-responsive promoter. Down-regulation of &lt;i&gt;Prkar1a&lt;/i&gt; by up to 70% was achieved in transgenic mouse tissues and embryonic fibroblasts, with concomitant changes in kinase activity and increased cell proliferation, respectively. Mice developed thyroid follicular hyperplasia and adenomas, adrenocortical hyperplasia, and other features reminiscent of primary pigmented nodular adrenocortical disease, histiocytic and epithelial hyperplasias, lymphomas, and other mesenchymal tumors. These were associated with allelic losses of the mouse chromosome 11 &lt;i&gt;Prkar1a&lt;/i&gt; locus, an increase in total type II PKA activity, and higher RIIβ protein levels. This mouse provides a novel, useful tool for the investigation of cyclic AMP, RIα, and PKA functions and confirms the critical role of &lt;i&gt;Prkar1a&lt;/i&gt; in tumorigenesis in endocrine and other tissues.&lt;/p&gt;&lt;/div&gt;
CAD/AVL SYSTEM FAULT TOLERANCE SYSTEM FALLBACK LEVELS AND CONCEPTS (2002)

Transit management and operation relies on stable and reliable CAD/AVL systems that allow for the highly efficient management of transit operations. As the communications operating system must keep the availability of voice and data radio systems high, even if a radio system component fails, it is vital that the key subsystems and devices have standby devices to take over during a failure. The paper provides a definition for fault tolerance, and then describes some of the areas where fault tolerance can be addressed within a CAD/AVL system.
Cyber Resilience for Self-Monitoring IoT Devices (2021)

Modern embedded IoT devices are an attractive target for cyber attacks. For example, they can be used to disable entire factories and ask for ransom. Recovery of compromised devices is not an easy task, because malware can subvert the original software and make itself persistent. In addition, many embedded devices do not implement remote recovery procedures and, therefore, require manual intervention.Recent proposals from NIST and TCG define concepts and building blocks for cyber resilience: protection, detection and recovery. In this paper, we describe a system which allows implementing cyber resilient IoT devices that can be recovered remotely and timely. The proposed architecture consists of trusted data monitoring, local and remote attack detection, and enforced connections to remote services as building blocks for attack detection and recovery. Further, hardware- and software-based implementations of such a system are presented.
A Microfluidic Pipette for Single-Cell Pharmacology (2010)

We report on a free-standing microfluidic pipette made in poly(dimethylsiloxane) having a circulating liquid tip that generates a self-confining volume in front of the outlet channels. The method is flexible and scalable as the geometry and the size of the recirculation zone is defined by pressure, channel number, and geometry. The pipette is capable of carrying out a variety of complex fluid processing operations, such as mixing, multiplexing, or gradient generation at selected cells in cell and tissue cultures. Using an uptake assay, we show that it is possible to generate dose-response curves in situ from adherent Chinese hamster ovary cells expressing proton-activated human transient receptor potential vanilloid (hTRPV1) receptors. Using confined superfusion and cell stimulation, we could activate hTRPV1 receptors in single cells, measure the response by a patch-clamp pipette, and induce membrane bleb formation by exposing selected groups of cells to formaldehyde/dithiothreitol-containing solutions, respectively. In short, the microfluidic pipette allows for complex, contamination-free multiple-compound delivery for pharmacological screening of intact adherent cells.
Salivary Histatin 5 Is an Inhibitor of Both Host and Bacterial Enzymes Implicated in Periodontal Disease (2001)

One of the salient features of periodontitis and gingivitis is the increase in the levels of bacterial and host-derived proteolytic enzymes in oral inflammatory exudates. This study evaluated the potential of histatin 5, a 24-residue histidine-rich salivary antimicrobial protein, to inhibit these enzymes. Using biotinylated gelatin as a substrate, histatin 5 was found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with 50% inhibitory concentrations (IC50s) of 0.57 and 0.25 microM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of histatin 5 were synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of histatin 5 showed much lower inhibitory activities (IC50, 21.4 and 20.5 microM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to histatin 5 against MMP-9. These results point to a functional domain localized in the C-terminal part of histatin 5. To evaluate the effect of histatin 5 on bacterial proteases, a detailed characterization of histatin 5 inhibition of gingipains from Porphyromonas gingivalis was carried out using purified Arg- and Lys-specific enzymes. Kinetic analysis of the inhibition of the Arg-gingipain revealed that histatin 5 is a competitive inhibitor, affecting only the Km with a K(i) of 15 microM. In contrast, inhibition of Lys-gingipain affected both the Km and Vmax, suggesting that both competitive and noncompetitive competitive processes underlie this inhibition. The inhibitory activity of histatin 5 against host and bacterial proteases at physiological concentrations points to a new potential biological function of histatin in the oral cavity.
A study of Israeli blood donors, asymptomatic carriers of hepatitis C virus, in relation to liver disease, cryoglobulinemia and transmission. (1995)

In order to study the asymptomatic hepatitis C virus (HCV)-positive blood donors in Israel we analyzed their sera for HCV-RNA using the polymerase chain reaction technique. We found that 0.44% of blood donors were anti-HCV positive. Of those who had repeatedly positive anti-HCV, 82% had evidence of HCV-RNA. One-third of them had elevated liver enzymes, but no detectable cryoglobulins were found in their sera. Although HCV-RNA was detected in the majority of the patients, we were unable to demonstrate vertical or horizontal transmission among the family members of our carrier population.
Impact of MIMO antenna design on communication channel capacity using the Kronecker model (2017)

This paper presents capacity calculations for different MIMO antenna systems. The capacity calculations are applied for both the Kronecker model, assuming both normal Gaussian channel and Gaussian symmetric channel. Three configurations of MIMO antenna system are investigated, which inhibit different mutual coupling effect due to different spacing and orientation of the antenna elements. Each configuration has four trapezoidal antenna elements. Numerical simulations depict the capacities versus SNR at the resonance frequencies of the three configurations. Results obtained aid in analyzing mutual coupling effect and spatial correlation on the capacity of the system using the adopted channel model. Practical experimental measurements of the scattering parameters for the fabricated antennas match with the numerical simulation results.
Shaping gas jet plasma density profile by laser generated shock waves (2014)

The Gaussian plasma density profile from a simple cylindrical nozzle jet was modified using laser generated shock wave. This modification provided great variety of density profiles suitable for different applications. The Gaussian plasma density distribution was modified into fast-rise slow-fall profile with adjustable gradients, almost flat-top profiles, and profiles with variable lengths. Position of the shock wave center and time delay were the major parameters used for shaping the density profiles. Other easily adjustable parameters such as shock wave energy and backing pressure provided linear scaling of the modified plasma densities.
Stereo video encoder optimization for mobile applications (2011)

This paper presents a stereo video encoder optimization for mobile applications. While video coding applications mostly concentrate on finding a good trade-off between rate and distortion, the additional constraint of limited processing power has to be considered for mobile applications. Realizing mobile video coding applications for stereo instead of 2D video is challenging, as twice the amount of video data has to be processed. Therefore, we investigate how the trade-off between rate, distortion, and complexity can be optimized for the multiview video coding (MVC) extension of the H.264/AVC standard. In the paper, we focus on the encoder, as its complexity is much higher and more configuration dependent than at the decoder. By enabling and disabling certain tools and setting different parameter values, the encoder complexity can be adapted for mobile applications. The presented results show that an optimized MVC encoder configuration performs significantly faster without impairing the rate-distortion performance.
Highly Regioselective, Catalytic Asymmetric Reductive Coupling of 1,3‐Enynes and Ketones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Reaction of Triplet Flavin with Indole. A Study of the Cascade of Reactive Intermediates Using Density Functional Theory and Time Resolved Infrared Spectroscopy (2002)

As a model for riboflavin, lumiflavin was investigated using density functional theory methods (B3LYP/6-31G* and B3LYP/6-31+G**) with regard to the proposed cascade of intermediates formed after excitation to the triplet state, followed by electron-transfer, proton-transfer, and radical[bond]radical coupling reactions. The excited triplet state of the flavin is predicted to be 42 kcal/mol higher in energy than the singlet ground state, and the pi radical anion lies 45.1 kcal/mol lower in energy than the ground-state flavin and a free electron in the gas phase. The former value compares to a solution-phase triplet energy of 49.8 kcal/mol of riboflavin. For the radical anion, the thermodynamically favored position to accept a proton on the flavin ring system is at N(5). A natural population analysis also provided spin density information for the radicals and insight into the origin of the relative stabilities of the six different calculated hydroflavin radicals. The resulting 5H-LF* radical can then undergo radical[bond]radical coupling reactions, with the most thermodynamically stable adduct being formed at C(4'). Vibrational spectra were also calculated for the transient species. Experimental time-resolved infrared spectroscopic data obtained using riboflavin tetraacetate are in excellent agreement with the calculated spectra for the triplet flavin, the radical anion, and the most stable hydroflavin radical.
Oligoanthranilamides. Non-Peptide Subunits That Show Formation of Specific Secondary Structure (1996)

A family of novel oligomers based on the anthranilamide nucleus has been prepared and shown to form well-defined secondary structural features. 1H NMR and X-ray crystallographic techniques have demonstrated that intramolecular hydrogen bonds play a key role in stabilizing both linear sheet and helical conformational forms.
ChemInform Abstract: ′ABNORMAL′ DISPLACEMENT IN THE REACTION OF 2‐(N‐METHYLPYRROLYL)METHYLTRIMETHYLAMMONIUM SALTS WITH SODIUM CYANIDE (1977)

Abstract Aus dem Ammoniumsalz (I) entsteht mit Cyanidionen ein Gemisch der Reaktionsprodukte (II)‐(IV).
Annealing-induced Interfacial Reactions between Gate Electrodes and HfO2/Si Gate Stacks Studied by Synchrotron Radiation Photoemission Spectroscopy (2007)

We have investigated the interfacial reactions between gate electrodes (polycrystalline‐Si and TiN) and HfO2/Si gate stacks by annealing in ultrahigh vacuum using synchrotron radiation photoemission spectroscopy. Hf 4f high‐resolution photoemission spectra have revealed that a Hf‐silicide formation starts at temperature 900 °C for a HfO2/Si structure without a gate electrode. On the other hand, in the case of a polycrystalline‐Si/HfO2/Si gate stack structure, the silicidation occurs at as low temperature as 700 °C. It is derived from the Si sub oxide which is formed at the polycrystalline‐Si/HfO2 interface by the oxygen diffusion from HfO2 to polycrystalline‐Si. In the case of a TiN/HfO2/Si gate stack structure, Hf nitridation occurs at 700 °C, and HfN is formed selectively by further annealing above 800 °C.
63 RESIBUFOGENIN REDUCES BLOOD PRESSURE IN A RAT MODEL OF PREECLAMPSIA (2005)

<h3></h3> Preeclampsia is a disorder which occurs only in human pregnancy. It consists of the development of hypertension, proteinuria and, often, excessive edema after 20 weeks of gestation in patients with previously normal blood pressure. It is the second most frequent cause of fetal wastage and maternal morbidity and mortality. Progress in understanding the pathophysiology of this disorder has been hampered by a lack of suitable animal models, especially of the early events in its pathogenesis. We have developed a rat model which reproduces many of the phenotypic characteristics of the human syndrome, including hypertension, proteinuria and intrauterine growth restriction. We have determined that the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), a cardiotonic bufadienolide which has vasoconstrictive properties, is elevated in these animals even before hypertension develops. Resibufogenin (RBG) is a structurally related analogue that differs from MBG only by the absence of the 5 β-hydroxyl-grouping. Furthermore, this compound has been determined to have no effect on angiogenesis. We therefore injected this material intraperitonealy daily in a dose of 15.3 μg/kg in five pregnant animals which had been rendered “preeclamptic” by administering desoxycorticosterone (DOCA) and replacing their drinking water with 0.9% saline. Systolic blood pressure (BP), measured with a tail cuff method, which rose to 132 ± 5 mm Hg from an initial mean value of 109 ± mm Hg (p&lt;0.001) due to the saline and DOCA treatment, fell to 117 ± 8 mm Hg after two days (p&lt;0.01). This reduction in BP persisted throughout the treatment reaching a mean value of 115 ± 10 mm Hg (p = 0.02) after seven days. These data indicate that RBG is effective in reducing BP in this rat model of human preeclampsia. We postulate that its mechanism of action is that of competitive inhibition of the effect of MBG to inhibit Na/K ATPase. Studies to evaluate this possibility are under way.
Direct Evidence for Control of the Pheromone-InducibleprgQOperon ofEnterococcus faecalisPlasmid pCF10 by a Countertranscript-Driven Attenuation Mechanism (2010)

The mating response of Enterococcus faecalis cells carrying the conjugative plasmid pCF10 is controlled by multiple regulatory circuits. Initiation of transcription of the prgQ conjugation operon is controlled by the peptide receptor protein PrgX; binding of the pheromone peptide cCF10 to PrgX abolishes PrgX repression, while binding of the inhibitor peptide iCF10 enhances repression. The results of molecular analysis of prgQ transcripts and genetic studies suggested that the elongation of prgQ transcripts past a putative terminator (IRS1) may be controlled by the interaction of nascent prgQ mRNAs with a small antisense RNA (Anti-Q) encoded within prgQ. Direct evidence for interaction of these RNAs, as well as the resulting effects on readthrough of prgQ transcription, has been limited. Here we report the results of experiments that (i) determine the inherent termination properties of prgQ transcripts in the absence of Anti-Q; (ii) determine the direct effects of the interaction of Anti-Q with nascent prgQ transcripts in the absence of complicating effects of the PrgX protein; and (iii) begin to dissect the structural components involved in these interactions. The results confirm the existence of alternative terminating and antiterminating forms of nascent prgQ transcripts in vivo and demonstrate that the interaction of Anti-Q with these transcripts leads to termination via inhibition of antiterminator formation. In vitro transcription assays support the major results of the in vivo studies. The data support a model for Anti-Q function suggested from recent studies of these RNAs and their interactions in vitro (S. Shokeen, C. M. Johnson, T. J. Greenfield, D. A. Manias, G. M. Dunny, and K. E. Weaver, submitted for publication).
Livrable D3.2 of the PERSEE project : 2D coding tools (intermediate version of the software) (2011)

Livrable D3.2 du projet ANR PERSEE
Electron cyclotron emission as e-beam diagnostic: Interpretation and experimental results (1995)

Note: Conference Digest of the 20th Int. Conference on Infrared and Millimeter Waves, Lake Buena Vista (Orlando), Florida, USA, December 1995, M8.3, 128 - 129 (1995) Reference CRPP-CONF-1995-001 Record created on 2008-05-13, modified on 2017-05-12
Photophysics and electrochemistry of hexanuclear tungsten halide clusters (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotophysics and electrochemistry of hexanuclear tungsten halide clustersThomas C. Zietlow, Daniel G. Nocera, and Harry B. GrayCite this: Inorg. Chem. 1986, 25, 9, 1351–1353Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ic00229a011https://doi.org/10.1021/ic00229a011research-articleACS PublicationsRequest reuse permissionsArticle Views315Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Biomechanics of Head, Neck, and Chest Injury Prevention for Soldiers: Phase 2 and 3 (2016)

Abstract : This is the final report for the cooperative agreement between the Virginia Tech Wake Forest University, Center for Injury Biomechanics and the U.S. Army entitled Biomechanics of Head, Neck, and Chest Injury Prevention for Soldiers. This final report includes activities performed between October27, 2015 and May 27, 2016. Task 1.2 details the development of a new biofidelic eye, with area sensing capabilities, for the Facial and Ocular CountermeasUre Safety (FOCUS) head form that can assess injury risk in both blunt and blast loading scenarios. Task 1.3 details the experimental blast overpressure testing performed on porcine eyes and the computational modeling efforts performed to assess eye injury risk due to blast overpressure loading. Task 1.3.1 details the research performed to improve the understanding of the biomechanics of the head and brain. Task 2.3 details the computational modeling efforts conducted to evaluate the response of the cervical spine and the effects of cervical arthrodesis and arthroplasty during simulated automobile collisions and rotary-wing aircraft impacts. This section also details the progress made on the development of a testing apparatus to evaluate cervical spine implants in survivable loading scenarios. Task 4.3 provides details on the National Research Symposium on Military Biomechanics that is hosted by the Virginia Tech Wake Forest University, Center for Injury Biomechanics annually in accordance with this cooperative agreement. Finally, the Dissemination of Knowledge section provides a list of all of the papers that have been published as a result of the research that was performed under this cooperative agreement, as well as the publication plan for additional publications. To date, this research has yielded nine (n=9) refereed publications and six (n=6) conference publications.
Pharmacokinetics of Three Neonicotinoid Insecticides upon Contact Exposure in the Western Honey Bee, Apis mellifera (2018)

Neonicotinoid insecticides differ in their acute contact toxicity to honey bees. We investigated the uptake, metabolic fate, and excretion of imidacloprid and two much less toxic chemotypes, thiacloprid and acetamiprid, upon contact exposure in honey bees because ADME data for this mode of entry are lacking. Pharmacokinetic parameters were analyzed by tracking a <sup>14</sup>C-label and by HPLC coupled to ESI-MS. Imidacloprid penetrates the honey bee cuticle much faster and more readily compared to thiacloprid and acetamiprid, thus revealing a pharmacokinetic component, i.e., faster penetration and higher steady-state internal body concentrations, contributing to its higher acute contact toxicity.