gebhart/patrepeval huggingface dataset:
Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo (1991)

MAP (mitogen-activated protein) kinase is shown to phosphorylate baculovirally expressed Raf-1 in vitro, generating one major tryptic phosphopeptide which co-migrated with a peptide from Raf-1 32P-labelled in situ. This peptide also undergoes an insulin-dependent increase in labelling. Thus the serine/threonine kinase Raf-1 may be a substrate for MAP kinase in vivo.
Editor's evaluation: Critical roles for ‘housekeeping’ nucleases in type III CRISPR-Cas immunity (2022)

Genetic and biochemical analyses reveal that the bacterial nucleases PNPase and RNase R work in concert with a type III-A CRISPR-Cas immune system to process small CRISPR RNAs and ensure robust immunity against foreign nucleic acid invaders.
Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E (2018)

To our knowledge, this is the first study to show that serum TNC levels in asthmatic patients are associated with clinical features of asthma and that the combination of serum TNC and periostin levels or combination of serum TNC and total IgE levels were more useful for asthma than each single marker, suggesting that serum TNC can serve as a novel biomarker for asthma.
Numerical and experimental investigation of three‐dimensional flow in extrusion dies (1993)

Abstract The univariant element, Q 1 P 0 , and the multivariant elements, Q P 0 and R P 0 , are compared for the numerical simulation of the flow in extrusion dies. The pressure distribution obtained by using the Q 1 P 0 element was found to be afflicted with the checkerboard pressure mode. On the other hand, the multivariant elements, Q P 0 and R P 0 , gave accurate and physically reasonable velocity and pressure distributions. The computed values of the pressure drop across extrusion dies matched well with the pressure drop determined experimentally.
A set-top box for end-to-end QoS management and home network gateway in IMS (2009)

As the next generation networks promise network convergence with services for both static and mobile networks, the research focus is converging towards standardizing a common infrastructure for all-IP networks. IP Multimedia Subsystem (IMS) is a recent initiative, which outlines a service delivery platform (SDP) framework. A flexible and robust QoS management system for IMS is essential to ascertain the achievability of service quality on these converged networks. As Triple and Quadruple Play services are the most celebrated services of IMS in the near future, the necessity of QoS assurance is becoming an imminent need of the hour. Multimedia services delivery in converged IP networks using IMS, concentrates on ensuring capabilities to ensure the best QoS. To meet these requirements, we have designed a set-top box which provides feedback in IMS management architecture to ensure end-toend QoS as well as enables the functionalities of Regional Gateway for the Home Network. Results of the simulation confirm the improvement of performance parameters and the quality of service.
Nanofabrication of reactive structure for low temperature bonding (2009)

Microsystems that are used for medical application mostly consist of temperature sensible components. Therefore the temperatures during the fabrication process must be limited. This paper deals with the fabrication of reactive nanostructures that have the capability to be used as local heat source and thus can be used for processes during the fabrication of temperature sensible systems. Hereby, heat is produced during a self propagating exothermal reaction of two different materials that are present in a multilayered system of horizontal or vertical arranged material films in nanoscale dimensions. In this paper the principle of the self propagating reaction of those reactive systems as well as their fabrication is shown.
Pathogenic mechanisms in the development of diffuse pulmonary fibrosis. (1996)

Diffuse pulmonary fibrosis is characterized by abnormal proliferation of mesenchymal cells, specifically fibroblasts and myofibroblasts, and by the accumulation of excessive amounts of matrix proteins, mainly collagens. The development of this pathological process is preceded by an inflammatory response, often dominated by macrophages and lymphocytes, which is mediated by the local release of chemoattractant factors, acting coordinately with an upregulation of cell-surface adhesion molecules. A subsequent persisting fibroproliferative reaction, in both interstitial and intraalveolar spaces, with progressive collagen accumulation distorts the lung architecture irreversibly. Excessive collagen deposition is the result of an imbalance in the collagen turnover rates characterized by a transient increase in collagen synthesis and a decrease in collagen degradation. Fibrosis is considered otherwise to be the final common pathway of a variety of lung disorders, and in this context, the diagnosis of pulmonary fibrosis implies the recognition of an advanced stage in the evolution of a complex process of abnormal repair.
Massively Parallel Dip–Pen Nanolithography with 55 000‐Pen Two‐Dimensional Arrays (2006)

Schreibstube plus: Einfach und flexibel präsentiert sich eine zweidimensionale Anordnung von 55 000 Rasterkraftmikroskop(AFM)-Federarmen als „Stifte“ bei der Hochdurchsatzbemusterung großer Flächen durch direktes Aufbringen von Molekülen. Dank pyramidaler Spitzen mit niedrigem Seitenverhältnis, gebogener Federarme und einer neuartigen Ausrichtungsmethode unter Nutzung der Schwerkraft können 1 cm2 große Molekülmuster mit einer Auflösung unter 100 nm erzeugt werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z603142_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
On optimal load setting of load-coupled cells in heterogeneous LTE networks (2014)

In multi-cell long term evolution (LTE) networks, the load levels that represent the cells' resource consumption are coupled due to mutual interference. The coupling relation forms a non-linear system, in which one cell's load governs the interference seen by the other cells. For heterogeneous networks with shared resource, load coupling takes place within the macro cell and small cell layers, as well as across the two layers. We investigate the problem of setting cell load levels for maximizing the overall system utility, where the utility is an increasing and concave function in served traffic. The paper presents the following contributions. First, we provide and prove the problem's NP-hardness. Second, for the sub-problem of resource allocation for given cell load, we present optimality conditions and tractability, along with detailing the computation for logarithmic utility functions. Third, for the non-convex problem of optimal load selection, we provide necessary optimality conditions to guide load adjustment in seeking utility improvement. Repeatedly applying load adjustment leads to a search algorithm for load optimization. Fourth, we illustrate cell load optimization for a representative LTE heterogeneous network scenario, and highlight the impact of utility function and the range of small cells on optimal load and user throughput.
Considérations sur la prorogation volontaire de compétence en matière de divorce et de responsabilité parentale (2017)

As a reaction to the complexity created by the diversification and the specialization of the norms governing the international disputes in family matters, the party autonomy is increasingly gaining ground as an effective tool for addressing the problems in this field. In the context of the discussions related with the Brussels II bis regulation's reform, our study is focused on the corresponding position of the European legislator in the field of jurisdiction for international matrimonial and parental responsibility disputes; illustrating some of the existing difficulties and their possible solutions, it also insists on the benefits that an the extension of the party autonomy would have in terms of reinforcement of the legal security, certainty and predictability for those involved in such disputes.
Transport and magnetic properties of in situ grown thin-film La–Y–Ca–Mn–O (1995)

We report a large magnetoresistance in in situ grown La0.60Y0.07Ca0.33MnOx thin films made at a low substrate temperature of 600 °C without postdeposition annealing. The zero-field resistivity peaks around 120 K. The resistivity peak is reduced by two orders of magnitude by a 6 T field. Comparison of transport and magnetization data reveals a correlation of conductivity versus magnetization below the ferromagnetic transition temperature, which may suggest a double-exchange-based conduction mechanism. Above the ferromagnetic transition at low fields, a quadratic dependence of conductivity on magnetization is found, consistent with a spin-scattering-limited conductivity.
Improvements to Signal Processing and Component Minaturization of Compact Resonator Fiber Optic Gyroscopes (2018)

This paper reports recent progress in resonator fiber optic gyroscope (RFOG) development towards realization of a next generation compact device for commercial navigation applications by incorporation of a novel signal processing technique to reduce error terms from backscattered light and producing a miniature a compact three-laser source for optical sensing. We have recently presented progress towards compact RFOGs using phase locked diode lasers and miniaturized optics on a silicon optical bench (SiOB), as well as demonstrating navigation-grade angle random walk performance with that architecture [1]. However, the most challenging technical barrier has been achieving the requisite bias stability for civil navigation applications (0.003 deg/hr drift). A major issue has been that error terms that cause bias drift have heretofore been addressed by competing, or mutually exclusive, countermeasures. The error mechanisms which have typically driven designs in different directions are (1) optical backscatter and (2) imperfections in the optical frequency modulation used to determine the resonance line center. We report updates to a modulation technique that has been demonstrated [2] to simultaneously solve these issues, resulting in the best performing RFOG to our knowledge. We illustrate its ability to reduce the drift due to optical backscatter while retaining a common modulation for cw and ccw resonance detection. Further improvements (achieved in a Honeywell partnership with TeraXion) to performance and size of a compact three-laser source previously reported [3] for the RFOG is also presented. It is based on a low-noise implementation of the Pound-Drever-Hall method and comprises high-bandwidth optical phase-locked loops. The outputs from three semiconductor distributed feedback lasers, mounted on thermo-electric coolers (TEC), are coupled with micro-lenses into a silicon photonics (SiP) chip that performs beat note detection and several other functions. The chip comprises phase modulators, variable optical attenuators, multi-mode-interference couplers, variable ratio tap couplers, integrated photodiodes and optical fiber butt-couplers. Electrical connections between a metallized ceramic and the TECs, lasers and SiP chip are achieved by wirebonds. All these components stand within a 35 mm by 35 mm package which is interfaced with 90 electrical pins and two fiber pigtails. One pigtail carries the signals from a master and slave lasers, while another carries that from a second slave laser. The pins are soldered to a printed circuit board featuring a micro-processor that controls and monitors the system to ensure stable operation over fluctuating environmental conditions. This work demonstrates a further step in the development of a compact RFOG with improved SWaP, ARW and Bias Stability.
Towards an Open-Domain Framework for Distilling the Outcomes of Personal Experiences from Social Media Timelines (2021)

Millions of people share details about their real-world experiences on social media. This provides an opportunity to observe the outcomes of common and critical situations and actions for individual and societal benefit. In this paper, we discuss our efforts to design and build an open-domain framework for mining the outcomes of any given experience from social media timelines. Through a number of example situations and actions across multiple domains, we discuss the kinds of outcomes we are able to extract and their relevance.
ChemInform Abstract: Stereospecific Synthesis, Structure—Activity Relationship, and Oral Bioavailability of Tetrahydropyrimidin‐2‐one HIV Protease Inhibitors. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design and Performance Evaluation of Resilient Optical Path Networks That Adopt Spatially-Jointed Flexible Waveband Routing (2021)

We propose a survivable SDM optical network architecture that adopts dedicated path protection and spatially-jointed flexible waveband routing. With a proposed heuristics-based design algorithm that considers the limited number of flexible wavebands, we can achieve almost identical routing performance to conventional optical networks while reducing the hardware cost. Numerical simulations on several topologies elucidate that the number of flexible wavebands, equals to the degree of WSSs in the spatially-jointed switching mode, can be small. The total number of necessary WSSs is successfully reduced by 75%/91% relative to conventional SDM networks with core-wise/spatially-jointed switching nodes.
The ruthenium(ii)-supported heteropolytungstates [Ru(dmso)3(H2O)XW11O39]6−(X = Ge, Si) (2004)

The novel Ru(II)-supported heteropolytungstates [Ru(dmso)(3)(H(2)O)XW(11)O(39)](6-)(X = Ge, Si) have been synthesized and characterized by single-crystal X-ray diffraction, multinuclear NMR ((183)W, (13)C, (1)H, (29)Si) and IR spectroscopy, elemental analysis and electrochemistry. The novel polyanion structure consists of a Ru(dmso)(3)(H(2)O) unit linked to a monolacunary [XW(11)O(39)](8-) Keggin fragment via two Ru-O-W bonds resulting in an assembly with C(1) symmetry. Polyanions 1 and 2 were synthesized by reaction of cis-Ru(dmso)(4)Cl(2) with [A-alpha-XW(9)O(34)](10-) in aqueous, acidic medium (pH 4.8). Tungsten-183 NMR of 1 leads to a spectrum with 11 peaks of equal intensity, indicating that the solid-state structure is preserved in solution. Electrochemistry studies revealed that 1 and 2 are stable in solution at least from pH 0 to 7, even in the presence of dioxygen. Their cyclic voltammetry patterns show mainly two two-electron reversible W-waves, those of the Si derivative 2 being located at slightly more negative potentials than those of the Ge derivative 1. The observed stability of 1 and 2 might be attributed to a stabilization of the Ru-center both by the strongly bound dmso ligands and the Keggin moiety. This stabilization drives the redox waves of Ru outside the accessible potential range. However, conditions were found to reveal, at least partially, the redox behavior of Ru in 1 and 2.
Widely Tunable Morphologies in Block Copolymer Thin Films Through Solvent Vapor Annealing Using Mixtures of Selective Solvents (2015)

Thin films of block copolymers are extremely attractive for nanofabrication because of their ability to form uniform and periodic nanoscale structures by microphase separation. One shortcoming of this approach is that to date the design of a desired equilibrium structure requires synthesis of a block copolymer <i>de novo</i> within the corresponding volume ratio of the blocks. In this work, we investigated solvent vapor annealing in supported thin films of poly(2-hydroxyethyl methacrylate)-<i>block</i>-poly(methyl methacrylate) [PHEMA-<i>b</i>-PMMA] by means of grazing incidence small angle X-ray scattering (GISAXS). A spin-coated thin film of lamellar block copolymer was solvent vapor annealed to induce microphase separation and improve the long-range order of the self-assembled pattern. Annealing in a mixture of solvent vapors using a controlled volume ratio of solvents (methanol, MeOH, and tetrahydrofuran, THF), which are chosen to be preferential for each block, enabled selective formation of ordered lamellae, gyroid, hexagonal or spherical morphologies from a single block copolymer with a fixed volume fraction. The selected microstructure was then kinetically trapped in the dry film by rapid drying. To our knowledge, this paper describes the first reported case where <i>in-situ</i> methods are used to study the transition of block copolymer films from one initial disordered morphology to four different ordered morphologies, covering much of the theoretical diblock copolymer phase diagram.
IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System (2015)

In addition to the classical Jak-Stat antiviral signaling pathway, IFN-λ1 inhibits HCV replication through the suppression of miRNA-122 transcription via an inflammatory Stat 3-HNF4α feedback loop. Inflammatory feedback circuits activated by IFNs during chronic inflammation expose non-responders to the risk of hepatocellular carcinoma.
Characterization and Immunogenicity of the CagF Protein of thecagPathogenicity Island ofHelicobacter pylori (2002)

Helicobacter pylori infection causes severe gastroduodenal diseases in humans. Its virulence is strongly increased by the presence of the cag pathogenicity island (cag PAI). It has been shown that CagA, a major antigen in humans, is translocated to the host cell via a secretion system encoded by the cag PAI. The roles of many of the proteins encoded within the cag PAI are not known. Here we report on the cloning and expression of CagF, one of those proteins. We show that CagF is associated to the outer membrane of H. pylori G27 and that the protein is always expressed with electrophoretic mobility variations among the 20 strains tested here. We have also found that natural infection with H. pylori is able to induce antibodies against CagF.
Projection-based embedded discrete fracture model (pEDFM) for flow and heat transfer in real-field geological formations with hexahedral corner-point grids (2021)

We present the projection-based embedded discrete fracture model (pEDFM) for hexahedral corner-point grid (CPG) geometries, for the simulation of hydrothermal processes in fractured porous media. Unlike the previously-developed pEDFM for structured box grids, our new development allows for the modeling of complex geometries defined with hexahedral CPG cells. It also advances the pEDFM method to include coupled flow and heat transfer systems. Mass and energy conservation equations are simulated in a fully-coupled manner using a fully-implicit (FIM) integration scheme. This allows for stable simulations, specially when large time steps are taken. Independent corner-point grids are imposed on the rock matrix and all fractures, with conductivities ranging from highly permeable to flow barriers. The connectivities between the non-neighboring grid cells are described such that a consistent discrete representation of the embedded fractures occurs within the corner-point grid geometry, specially as the quadrilateral interfaces are allowed to be fully flexible. Various numerical tests including geologically-relevant and real-field models, which are established in the literature, are conducted to demonstrate the applicability of the developed method. It is shown that pEDFM can accurately capture the physical influence of both highly conductive fractures and flow barriers on the flow and heat transfer fields in complex reservoir geometries. This development is promising for flow simulations of real-field geo-models, increasing the discretization flexibility and enhancing the computational performance for capturing explicit fractures accurately.
Micromachining and material change characterization using femtosecond laser oscillators (2002)

We use third harmonic generation (THG) microscopy to image waveguides and single-shot structural modifications produced in bulk glass using femtosecond laser pulses. THG microscopy reveals the internal structure of waveguides written with a femtosecond laser oscillator, and gives a three-dimensional view of the complicated morphology of the structural changes produced with single, above-threshold femtosecond pulses. We find that THG microscopy is as sensitive to refractive index change as differential interference contrast microscopy, while also offering the three-dimensional sectioning capabilities of a nonlinear microscopy technique. It is now possible to micromachine three-dimensional optical devices and to image these structures in three dimensions, all with a single femtosecond laser oscillator.
Making double patterning cost single (2009)

The <i>Journal of Micro/Nanopatterning, Materials, and Metrology</i> (JM3) publishes peer-reviewed papers on the core enabling technologies that address the patterning needs of the electronics industry.
Visibility-aware 3D models transmission for virtual reality applications (2023)

In this paper, we propose a visibility-aware 3D models transmission method for Virtual Reality applications. The proposed method dynamically adjusts the quality of individual models based on available network resource and their visibility to maximize user-perceived quality under delay constraints. Experiment results show that the proposed method can significantly improve the viewport quality compared to conventional methods.
GERBIL (2015)

We present GERBIL, an evaluation framework for semantic entity annotation. The rationale behind our framework is to provide developers, end users and researchers with easy-to-use interfaces that allow for the agile, fine-grained and uniform evaluation of annotation tools on multiple datasets. By these means, we aim to ensure that both tool developers and end users can derive meaningful insights pertaining to the extension, integration and use of annotation applications. In particular, GERBIL provides comparable results to tool developers so as to allow them to easily discover the strengths and weaknesses of their implementations with respect to the state of the art. With the permanent experiment URIs provided by our framework, we ensure the reproducibility and archiving of evaluation results. Moreover, the framework generates data in machine-processable format, allowing for the efficient querying and post-processing of evaluation results. Finally, the tool diagnostics provided by GERBIL allows deriving insights pertaining to the areas in which tools should be further refined, thus allowing developers to create an informed agenda for extensions and end users to detect the right tools for their purposes. GERBIL aims to become a focal point for the state of the art, driving the research agenda of the community by presenting comparable objective evaluation results.
Structural and Morphological Properties of Carbon Supports: Effect on Catalyst Degradation (2010)

The object of this work was to identify correlations between performance losses of Pt electrocatalysts on carbon support materials and the chemical and morphological parameters that describe them. Accelerated stress testing, with an upper potential of 1.2 V, was used to monitor changes to cathode properties, including kinetic performance and effective platinum surface area losses. The structure and chemical compositions were studied using X-ray Photoelectron Spectroscopy and Scanning Electron Microscopy coupled with Digital Image Processing. As this is an ongoing study, it is difficult to draw firm conclusions, though a trend between support surface area overall performance loss was found to exist.