gebhart/patrepeval huggingface dataset:
ANTIGENIC VARIATION AMONG NEWLY ISOLATED STRAINS OF PARAINFLUENZA TYPE 4 VIRUS1 (1964)

Journal Article ANTIGENIC VARIATION AMONG NEWLY ISOLATED STRAINS OF PARAINFLUENZA TYPE 4 VIRUS Get access JOSE CANCHOLA, JOSE CANCHOLA Search for other works by this author on: Oxford Academic PubMed Google Scholar ANDREW J. VARGOSKO, ANDREW J. VARGOSKO Search for other works by this author on: Oxford Academic PubMed Google Scholar HYUN WHA KIM, HYUN WHA KIM Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT H. PARROTT, ROBERT H. PARROTT Search for other works by this author on: Oxford Academic PubMed Google Scholar EMILY CHRISTMAS, EMILY CHRISTMAS Search for other works by this author on: Oxford Academic PubMed Google Scholar BARBARA JEFFRIES, BARBARA JEFFRIES Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT M. CHANOCK ROBERT M. CHANOCK Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 79, Issue 3, May 1964, Pages 357–364, https://doi.org/10.1093/oxfordjournals.aje.a120390 Published: 01 May 1964 Article history Received: 27 December 1963 Published: 01 May 1964
Preliminary Characterization of Enterooxyntic Activity on the Guinea Pig Oxyntic Cell* (1985)

Stimuli originating in the small intestine enhance gastric acid secretion, an effect termed the intestinal phase of gastric secretion. A humoral agent, enterooxyntin (EO) may mediate this effect. Mechanical distension of an ex vivo-perfused segment of canine jejunum caused the release of EO measured by cytochemical quantification of hydroxyl ion production (HIP) in guinea pig gastric oxyntic cells, an index of acid secretion. The H2 receptor antagonist, cimetidine (10(-5) M), and diamine oxidase, which hydrolyzes endogenous histamine, reduced HIP by 60% and 48%, respectively. Atropine (10(-5) M), the muscarinic cholinergic antagonist, reduced HIP by 75%. EO-induced HIP was also inhibited partially by the Ca2+ antagonist EGTA (10(-6) M) and by blockade of calcium channels with LaCl3 (10(-6) M). EO does not appear to operate through any single pathway. EO may be a single substance, different from gastrin, or a mixture of substances that have stimulatory effects on the oxyntic cell. Its action on the oxyntic cell is apparently mediated by both histaminergic and cholinergic pathways. Since neither cimetidine nor atropine completely inhibited EO-induced HIP, a direct effect of EO on the oxyntic cell seems likely and appears to depend on Ca2+. Isolation and purification of EO will be necessary to better assess the potency, efficacy, and the detailed cellular mechanisms of EO action.
A deep learning algorithm to detect chronic kidney disease from retinal photographs in community-based populations (2020)

Summary Background Screening for chronic kidney disease is a challenge in community and primary care settings, even in high-income countries. We developed an artificial intelligence deep learning algorithm (DLA) to detect chronic kidney disease from retinal images, which could add to existing chronic kidney disease screening strategies. Methods We used data from three population-based, multiethnic, cross-sectional studies in Singapore and China. The Singapore Epidemiology of Eye Diseases study (SEED, patients aged ≥40 years) was used to develop (5188 patients) and validate (1297 patients) the DLA. External testing was done on two independent datasets: the Singapore Prospective Study Program (SP2, 3735 patients aged ≥25 years) and the Beijing Eye Study (BES, 1538 patients aged ≥40 years). Chronic kidney disease was defined as estimated glomerular filtration rate less than 60 mL/min per 1·73m2. Three models were trained: 1) image DLA; 2) risk factors (RF) including age, sex, ethnicity, diabetes, and hypertension; and 3) hybrid DLA combining image and RF. Model performances were evaluated using the area under the receiver operating characteristic curve (AUC). Findings In the SEED validation dataset, the AUC was 0·911 for image DLA (95% CI 0·886 −0·936), 0·916 for RF (0·891–0·941), and 0·938 for hybrid DLA (0·917–0·959). Corresponding estimates in the SP2 testing dataset were 0·733 for image DLA (95% CI 0·696–0·770), 0·829 for RF (0·797–0·861), and 0·810 for hybrid DLA (0·776–0·844); and in the BES testing dataset estimates were 0·835 for image DLA (0·767–0·903), 0·887 for RF (0·828–0·946), and 0·858 for hybrid DLA (0·794–0·922). AUC estimates were similar in subgroups of people with diabetes (image DLA 0·889 [95% CI 0·850–0·928], RF 0·899 [0·862–0·936], hybrid 0·925 [0·893–0·957]) and hypertension (image DLA 0·889 [95% CI 0·860–0·918], RF 0·889 [0·860–0·918], hybrid 0·918 [0·893–0·943]). Interpretation A retinal image DLA shows good performance for estimating chronic kidney disease, underlying the feasibility of using retinal photography as an adjunctive or opportunistic screening tool for chronic kidney disease in community populations. Funding National Medical Research Council, Singapore.
Aware service base on the assembly of multiple weak location sensors (2010)

Indoor location information is important for the awareness computing environment. One single location sensor always is not accurate and applicable enough for providing the right service to the user. In this paper, an OSGi based simulation system is introduced firstly, and then we propose a framework to support the combination of several weak location sensors. With this combination model, multiple weak location sensors can work together to provide the better location aware service to the user. The experiment platform which consists of RFID array location sensor, RF sensor, pressure sensor and other sensors can work together in the OSGi based simulation system, experiment results show that the assembly of multiple weak sensors do better than the solo sensor. It can help the designers to achieve the better cost-performance for the awareness applications between various possible combinations.
Comparing decoding performance between functionally defined neural populations (2015)

Neurons in primary motor cortex can be divided into functional populations based on the width of their spike waveforms. These ensembles have different response properties that may subserve different roles in movement generation. Yet, how these differences impact offline decoding performance remains unknown. Here, we show that neurons exhibiting narrow spike waveforms outperform wide spiking neurons in decoding several features of movement. We further examine how decoding performance scales with respect to the number of neurons in the decoder, and show that an ensemble containing only narrow spiking units outperforms other models. These results suggest that it may be useful to consider spike waveform width when designing neural decoders.
Draft Genome of the Filarial Nematode Parasite Brugia malayi (2007)

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.
FEP-Guided Selection of Bicyclic Heterocycles in Lead Optimization for Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase (2006)

Monte Carlo simulations using free energy perturbation theory have been used to guide the selection of bicyclic heterocycles in the lead optimization of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Good correlation is found between predicted and observed activities. Six compounds are reported with EC50 values below 20 nM for protection of human MT-2 cells against the cytopathogenicity of HIV-1. Striking variation in activity is found and analyzed for an isomeric pyrrolopyrimidine and pyrrolopyrazine pair.
Safety aspects in the development of an infectious bovine rhinotracheitis marker vaccine. (1995)

Clinical trials in cattle demonstrated that the IBR marker modified live vaccine based on the gE-deleted IBR strain Difivac is immunogenic and safe for bovines of all ages. Potential effects of the vaccine virus have also been tested in swine and sheep and proved safe for these species as well. For evaluation of other environmental aspects, the spread of the vaccine virus after immunisation was investigated. The data indicated that the vaccine virus may be shed by immunised animals but that it has a limited ability to pass from animal to animal. It was also demonstrated that the attenuated Difivac strain does not revert to virulence during calf passage. Preliminary results indicated that the gE-deleted vaccine virus of the IBR marker vaccine cannot be reactivated after dexamethasone treatment, an important advantage for a vaccine strain. Furthermore, immunisation with the Difivac strain reduced the ability of a superinfecting challenge virus to become latent or to be reactivated.
From PtCl2‐ and Acid‐Catalyzed to Uncatalyzed Cycloisomerization of 2‐Propargyl Anilines: Access to Functionalized Indoles. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel ultrasound-contrast-agent dilution method for assessment of left ventricular ejection faction (2006)

Background: Left ventricular ejection fraction (LVEF) is an important determinant of prognosis. We evaluated the accuracy of a novel fast method for LVEF quantification based on indicator dilution curve (IDC) principles (figure 1) and compared the results with contrast-enhanced biplane LVEF assessment. Method: a 10 ml diluted (1:100) ultrasound-contrast bolus (SonoVue ®) was injected intravenously in thirty patients (pts) (20 male, age 65 ± 10) with known or suspected heart disease. In 22 pts multiple recordings were made and in 12 pts injections were repeated after implantation of a biventricular pacemaker, leading to 68 measurements. The developed algorithm used the left atrium and LV IDC for the LVEF measurement. For the biplane enhanced LVEF measurements a 0.5 ml pure ultrasound-contrast bolus (SonoVue ®) was administered to obtain multiple four- and two-chamber recordings. Results: according to contrast enhanced biplane assessments, the LVEF ranged from 10 to 75 % while the LV end-diastolic volume ranged from 80 to 521 ml. The mean LVEF measured by the biplane and the IDC method was 33 ± 17 % and 35 ± 18 %, respectively. A correlation coefficient r=0.91 was observed between the two methods (figure 2). Conclusion: A new fast method for LVEF assessment based on IDC principles is described and comparison with contrast enhanced biplane LVEF quantification shows accurate results. The proposed method also allows simultaneous quantification of right ventricular EF based on the same IDC principles.
1932: It is 3-D Imaging- No More Imagining The Era of 3-D CT Urogram, 3-D Angiogram, 3-D Urethrogram (2004)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 12, 2004, 8:00am- 12:00 pm1 Apr 20041932: It is 3-D Imaging- No More Imagining The Era of 3-D CT Urogram, 3-D Angiogram, 3-D Urethrogram Daniel Yachia, Ronen Rub, Eduard Jolkowski, Burak Karatas, Nahum Erlich, Uri Soimu, and Gavriel Bartal Daniel YachiaDaniel Yachia More articles by this author , Ronen RubRonen Rub More articles by this author , Eduard JolkowskiEduard Jolkowski More articles by this author , Burak KaratasBurak Karatas More articles by this author , Nahum ErlichNahum Erlich More articles by this author , Uri SoimuUri Soimu More articles by this author , and Gavriel BartalGavriel Bartal More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)39124-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1932: It is 3-D Imaging- No More Imagining The Era of 3-D CT Urogram, 3-D Angiogram, 3-D Urethrogram." The Journal of Urology, 171(4S), p. 510 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 510 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Daniel Yachia More articles by this author Ronen Rub More articles by this author Eduard Jolkowski More articles by this author Burak Karatas More articles by this author Nahum Erlich More articles by this author Uri Soimu More articles by this author Gavriel Bartal More articles by this author Expand All Advertisement PDF downloadLoading ...
Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A (2021)

Brasilicardin A (1) consists of an unusual anti/syn/anti-perhydrophenanthrene skeleton with a carbohydrate side chain and an amino acid moiety. It exhibits potent immunosuppressive activity, yet its mode of action differs from standard drugs that are currently in use. Further pre-clinical evaluation of this promising, biologically active natural product is hampered by restricted access to the ready material, as its synthesis requires both a low-yielding fermentation process using a pathogenic organism and an elaborate, multi-step total synthesis. Our semi-synthetic approach included a) the heterologous expression of the brasilicardin A gene cluster in different non-pathogenic bacterial strains producing brasilicardin A aglycone (5) in excellent yield and b) the chemical transformation of the aglycone 5 into the trifluoroacetic acid salt of brasilicardin A (1 a) via a short and straightforward five-steps synthetic route. Additionally, we report the first preclinical data for brasilicardin A.
Integrated turnkey soliton microcombs: Data and Code (2020)

<strong>Data.zip</strong> contains raw datasets generated in the experiment and analysed during the study. <strong>Code.zip</strong> contains the MATLAB code for processing the data and generating figures in the paper and its supplementary information, as well as the Mathematica code to model the turnkey soliton generation. Please put the MATLAB script in the same directory as the <strong><em>Data</em></strong> folder and add the folder <em><strong>Code/Lib</strong></em> to MATLAB path.
Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice. (1992)

The function of the pituitary-gonadal axis in normal (immunocompetent) and nude (immunocompromised) mice, like that of other species, can be suppressed by luteinizing hormone-releasing hormone (LH-RH) agonists and antagonists administered by continuous release systems and, therefore, nude mice provide a valuable model for investigation of the effects of LH-RH analogues on growth of xenografts of human cancers. To extend our findings further, we treated male nude mice bearing xenografts of human prostate adenocarcinoma PC-82, for 42 days, with sustained release formulations (microcapsules or microgranules) of the agonist [D-Trp6]LH-RH, the antagonist [Ac-D-Nal(2)1,D-Phe(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH- RH (SB-75), or the somatostatin analogue D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160). At necropsy, in mice given microcapsules releasing 25 micrograms/day of [D-Trp6]-LH-RH, tumor weight and volume were significantly decreased, compared with control mice, and weights of testes, ventral prostate, and seminal vesicles were also reduced in this group. In mice which received microgranules liberating 50 micrograms/day of antagonist SB-75, there was a greater decrease in tumor weight and volume than that produced by the agonist and a significant reduction in the weight of the testes and accessory sex organs. Histological parameters also demonstrated significant tumor inhibition, with the best results being obtained by treatment with the antagonist SB-75. The tumor inhibition induced by SB-75 was demonstrated to be due to decreased cellular proliferation, with enhanced cellular death (i.e., apoptosis) of the PC-82 cells. Microcapsules releasing 50 micrograms/day of RC-160 decreased tumor weight and volume by 23% and 28%, respectively, but this reduction was not significant. Serum levels of testosterone were decreased by 90% in mice given the LH-RH agonist and by 94% in response to the antagonist SB-75. Serum levels of prostate-specific antigen were significantly lower in mice treated with LH-RH analogues, with the antagonist SB-75 causing a greater reduction. A ratio of prostate-specific antigen to tumor weight suggests that levels of serum prostate-specific antigen may be correlated with tumor mass. Using sensitive multipoint micromethods, one class of binding sites for LH-RH, with a dissociation constant of 7.8 +/- 1.2 nM and a maximal binding capacity of 126.4 +/- 23.1 fmol/mg protein, was found in the control tumors. Tumors from mice treated with either LH-RH agonist or antagonist, but not somatostatin analogue RC-160, showed a significant reduction in maximal binding capacity for LH-RH, compared to control tumors.(ABSTRACT TRUNCATED AT 400 WORDS)
Improving the Performance and Usability of Server Systems through Dynamic Use of Persistent Memory (2021)

본 연구는 DIMM 인터페이스 기반의 비휘발성 메모리(PM)를 사용하는 컴퓨팅 시스템에서 PM을 관리하기 위한 메모리 관리 시스템을 개발하는 연구이다. PM은 메인 메모리, 스토리지, 또는 스토리지 캐시 레이어로 사용될 수 있다는 전제에서 연구되어 왔다. 본 연구에서는 이러한 역할을, 각각이 아니라, 동시에 할 수 있도록 하는, PM을 위한 메모리 관리 시스템을 개발한다. 이 관리 시스템을 하이브리드 메모리 관리 시스템(Hybrid Memory Management System, HMMS)이라 부른다. HMMS는 DRAM과 PM이 공존하는 환경을 가정하며 컴퓨팅 시스템 상태와 사용자의 요구 성질을 반영하여 이 세 가지 역할을 동적으로, 적절하게 배분한다. HMMS의 도입을 통해서 다양한 스케일의 컴퓨팅 시스템의 기능적, 성능적인 향상을 목표로 한다.
USE OF ELASTIC PRESTACK SEISMIC DATA FOR RESERVOIR IMAGING AND CHARACTERIZATION (2002)

We confirmed that metabolic syndrome had favorable effects on lower urinary tract symptoms, including voiding and storage symptoms in healthy middle-aged men. This beneficial effect was most significant in men with enlarged prostate and/or high prostate specific antigen levels.
An investigation of thein vivo stability of poly(ether urethaneurea) blood sacs (1999)

In this paper we investigate the biostability of a series of Biolon blood sacs that were utilized in electric total artificial hearts for time periods of up to 19 weeks. A battery of experimental probes, including scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), were used to characterize the bulk and surface properties of explanted and control blood sacs. Gel permeation chromatography (GPC) experiments showed that generally there was a dramatic increase in average molecular weight at longer implantation times. However, SEM and GPC observations suggest significant deterioration of the flex regions of right blood sacs after 17 weeks of service. XPS experiments indicated appreciable silicon and hydrocarbon concentrations on blood-contacting surfaces both before and after implantation, and we speculate as to their origin.
Theileria annulata histone deacetylase 1 (TaHDAC1) initiates schizont to merozoite stage conversion (2022)

A fungal metabolite, FR235222, specifically inhibits a histone deacetylase of the apicomplexan parasite Toxoplasma gondii and TgHDAC3 has emerged as a key factor regulating developmental stage transition in this species. Here, we exploited FR235222 to ask if changes in histone acetylation regulate developmental stage transition of Theileria annulata, another apicomplexan species. We found that FR235222 treatment of T. annulata-infected transformed leukocytes induced a proliferation arrest. The blockade in proliferation was due to drug-induced conversion of intracellular schizonts to merozoites that lack the ability to maintain host leukocyte cell division. Induction of merogony by FR235222 leads to an increase in expression of merozoite-marker (rhoptry) proteins. RNA-seq of FR235222-treated T. annulata-infected B cells identified deregulated expression of 468 parasite genes including a number encoding parasite ApiAP2 transcription factors. Thus, similar to T. gondii, FR235222 inhibits T. annulata HDAC (TaHDAC1) activity and places parasite histone acetylation as a major regulatory event of the transition from schizonts to merozoites.
A New Combined Approach to Solve the Cell Formation Problem with Alternative Routings (2002)

info:eu-repo/semantics/published
vRead (2015)

With its unlimited scalability and on-demand access to computation and storage, a virtualized cloud platform is the perfect match for big data systems such as Hadoop. However, virtualization introduces a significant amount of overhead to I/O intensive applications due to device virtualization and VMs or I/O threads scheduling delay. In particular, device virtualization causes significant CPU overhead as I/O data needs to be moved across several protection boundaries. We observe that such overhead especially affects the I/O performance of the Hadoop distributed file system (HDFS). In fact, data read from an HDFS datanode VM must go through virtual devices multiple times --- incurring non-negligible virtualization overhead --- even though both client VM and datanode VM may be running on the same machine. In this paper, we propose vRead, a programmable framework which connects I/O flows from HDFS applications directly to their data. vRead enables direct "reads" to the disk images of datanode VMs from the hypervisor. By doing so, vRead can significantly avoid device virtualization overhead, resulting in improved I/O throughput as well as CPU savings for Hadoop workloads and other applications relying on HDFS.
Polylactosaminoglycan Glycomics: Enhancing the Detection of High-molecular-weight N-glycans in Matrix-assisted Laser Desorption Ionization Time-of-flight Profiles by Matched Filtering (2013)

For over 30 years, protocols based on the mass spectrometry (MS) of permethylated derivatives, complemented by enzymatic degradations, have underpinned glycomic experiments aimed at defining the structures of individual glycans present in the complex mixtures that are characteristic of biological samples. Both MS instrumentation and sample handling have improved markedly in recent years, enabling greater sensitivity and better signal-to-noise ratios, thereby facilitating the detection of glycans at much higher masses than could be achieved in the past. The latter is especially important for the characterization of the biologically important class of N-glycans that carry polylactosaminoglycan chains. Such advances in data acquisition heighten the need for informatics tools to assist in glycan structure assignment. Here, utilizing mouse lung tissue as a model system, we present evidence of polylactosaminoglycan-containing N-glycans with permethylated molecular weights exceeding 13 kDa. We show that antennae branching patterns and lengths can be successfully determined at these high masses via MS/MS experiments, even when MS ion counts are very low. We also describe the development and application of a matched filtering algorithm for assisting high-molecular-weight glycan detection and structure assignment.