gebhart/patrepeval huggingface dataset:
Face reconstruction in the wild (2011)

We address the problem of reconstructing 3D face models from large unstructured photo collections, e.g., obtained by Google image search or from personal photo collections in iPhoto. This problem is extremely challenging due to the high degree of variability in pose, illumination, facial expression, non-rigid changes in face shape and reflectance over time and occlusions. In light of this extreme variability, no single reconstruction can be consistent with all of the images. Instead, we define as the goal of reconstruction to recover a model that is locally consistent with the image set. I.e., each local region of the model is consistent with a large set of photos, resulting in a model that captures the dominant trends in the input data for different parts of the face. Our approach leverages multi-image shading, but unlike traditional photometric stereo approaches, allows for changes in viewpoint and shape. We optimize over pose, shape, and lighting in an iterative approach that seeks to minimize the rank of the transformed images. This approach produces high quality shape models for a wide range of celebrities from photos available on the Internet.
Catalytic Inhibition of Eukaryotic Topoisomerases I and II by Flavonol Glycosides Extracted from Vicia faba and Lotus edulis (2011)

Topoisomerases are essential enzymes involved in all processes of DNA metabolism, and their inhibitors have been identified as potential anticancer agents. The present study examined the effect of nine polyphenolic compounds derived from parts of two unique varieties of the Leguminosae, Vicia faba and Lotus edulis, on the activity of eukaryotic topoisomerases. We identified polyphenolic compounds that act as catalytic inhibitors of wheat germ topoisomerase I (IC50: 120-350 μM), human topoisomerase I (IC50: 110-260 μM), and human topoisomerase II (IC50: 240-600 μM) activities. Some compounds inhibited all enzymatic activities to a similar extent, while others exhibited specificity toward individual enzymes. The strongest catalytic inhibitor of all the examined enzymes was a kaempherol glycoside with an acetyl group linked to a sugar moiety. In addition, this compound inhibited the growth of human cancer cell lines MCF7, HeLa, and HepG2. The inhibition of topoisomerase I and II activities observed by the specific compounds possibly implies a role as potential agents in the prevention and therapy of cancer.
Abstract 1020: BRD9 defines a novel mammalian SWI/SNF (BAF) complex configuration which supports proliferation in AML (2017)

Abstract Genes encoding subunits of the mammalian SWI/SNF (BAF) ATP-dependent chromatin remodeling complexes are mutated in over 20% of human cancer. Specific subunits are mutated in specific malignancies, highlighting their tissue-specific protective roles; moreover, synthetic lethal screens have uncovered genetic- and lineage-based features which confer dependence on specific mSWI/SNF subunits. As combinatorial complexity represents a major challenge, identification of specialized mSWI/SNF configurations, subunit-specific functions, binding restrictions, and exclusivity relationships is critical for understanding oncogenic mechanisms and for the selection of appropriate therapeutic agents targeting mSWI/SNF complex subunits. Here, we discover that BRD9, a recently identified mSWI/SNF subunit, defines a novel complex configuration distinct from BAF and PBAF, which we term non-canonical BAF, or ncBAF. We used biochemical methods to isolate BRD9-containing complexes and find that BRD9 selectively marks a sub-stoichiometric group of mSWI/SNF complexes of smaller molecular weight that lack several members of canonical BAF complexes such as BAF47 and ARID1A. Moreover, chemoproteomics using a BRD9 inhibitor (GSK) isolates only ncBAF and does not resolve BAF-specific or PBAF-specific components, including the highly related bromodomain-containing subunit BRD7. We further identified regions of BRD9 and BRD7 that confer specificity of these subunits to ncBAF and PBAF complexes, respectively, resolving their mSWI/SNF binding domains. Using genome-wide ChIP-seq and RNA-seq experiments, we determined that ncBAF complexes target a distinct subset of all mSWI/SNF complex target genes and, consistent with previous studies, maintain proliferation of AML cells. Finally, we applied a newly- generated approach to deriving functional relationships within and between protein complex families from shRNA and CRISPR-based genetic screening datasets across hundreds of cancer cell lines to explore ncBAF-specific subunits. We find that ncBAF-specific complex subunits form a distinct functional module, supporting biochemical studies and pointing to the specific and divergent functions of the ncBAF configuration. Cancers of hematologic origin collectively exhibit the most significant responses to perturbation of three ncBAF subunits including BRD9, substantiating previous small molecule screening efforts using BRD9 bromodomain inhibitors. These data demonstrate that ncBAF complexes represent a novel BAF complex composition with distinct function in cancer. Citation Format: Brittany C. Michel, Joshua Pan, Robin M. Meyers, Paola Grandi, Phillip G. Humphreys, Neil G. Garton, Rab K. Prinja, Cigall Kadoch. BRD9 defines a novel mammalian SWI/SNF (BAF) complex configuration which supports proliferation in AML [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1020. doi:10.1158/1538-7445.AM2017-1020
Orthotopic VX rabbit tongue cancer model with FDG–PET and histologic characterization (2012)

This model may be a useful model of orthotopic head and neck cancer for future surgical or imaging research.
Analog VLSI neural network integrated circuits (1991)

Two analog very large scale integration (VLSI) vector matrix multiplier integrated circuit chips were designed, fabricated, and partially tested. They can perform both vector-matrix and matrix-matrix multiplication operations at high speeds. The 32 by 32 vector-matrix multiplier chip and the 128 by 64 vector-matrix multiplier chip were designed to perform 300 million and 3 billion multiplications per second, respectively. An additional circuit that has been developed is a continuous-time adaptive learning circuit. The performance achieved thus far for this circuit is an adaptivity of 28 dB at 300 KHz and 11 dB at 15 MHz. This circuit has demonstrated greater than two orders of magnitude higher frequency of operation than any previous adaptive learning circuit.
Chemical Origin of Phosphine in Nature (2010)

Phosphine (PH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) is a natural gaseous carrier of phosphorus in its biogeochemical cycles, has been found ubiquitously present in the environment. The origin of phosphine in various environmental sites is still under debated, although phosphine evolution used to be reported from microbial habitats. The tentative experiments show that phosphine gas could be produced by aqueous or acid corrosion from phosphorus-containing impurities in iron. The concentration of phosphine liberated by aqueous corrosion was of the same order of magnitude (ng/kg) as those detected in natural environment. Acid could accelerate corrosion and promote the production of phosphine. The quantity of phosphine liberated by 0.5 mol/L sulfuric acid corrosion was three magnitude orders (ug/kg) higher than that in aqueous corrosion, which may provide a convincing explanation for the significant occurrence of phosphine in strong acidic condition (landfill gas, anaerobic fermentation gas, etc). It was shown that phosphine emission in air as headspace gas was higher than in nitrogen gas under aqueous corrosion, while different headspace gas (air or nitrogen gas) showed little effect on phosphine liberation by acid corrosion. Phosphine produced by reduced type iron powder (analytical reagent) was lower than by technical iron filings. Iron filings after grinding could enhance the emission of phosphine. Under acid corrosion, an exponential positive correlation between the weight of iron filings(x, g) and phosphine production concentration (y, ng/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) has been established (y, = 58.49lnx + 343, R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.9561, n = 18). A positive correlation between the concentrations of acid and phosphine production could also be observed. Results suggested that chemical corrosion of phosphorus-containing in iron filings could be considered as a source of phosphine emission in the environment. Further studies should examine the phosphorus species existing in iron and evaluate the chemical process responsible for the production of phosphine by iron corrosion.
UAV-Aided Interference Assessment for Private 5G NR Deployments:\n Challenges and Solutions (2020)

Industrial automation has created a high demand for private 5G networks, the\ndeployment of which calls for an efficient and reliable solution to ensure\nstrict compliance with the regulatory emission limits. While traditional\nmethods for measuring outdoor interference include collecting real-world data\nby walking or driving, the use of unmanned aerial vehicles (UAVs) offers an\nattractive alternative due to their flexible mobility and adaptive altitude. As\nUAVs perform measurements quickly and semiautomatically, they can potentially\nassist in near realtime adjustments of the network configuration and\nfine-tuning its parameters, such as antenna settings and transmit power, as\nwell as help improve indoor connectivity while respecting outdoor emission\nconstraints. This article offers a firsthand tutorial on using aerial 5G\nemission assessment for interference management in nonpublic networks (NPNs) by\nreviewing the key challenges of UAV-mounted radio-scanner measurements.\nParticularly, we (i) outline the challenges of practical assessment of the\noutdoor interference originating from a local indoor 5G network while\ndiscussing regulatory and other related constraints and (ii) address practical\nmethods and tools while summarizing the recent results of our measurement\ncampaign. The reported proof of concept confirms that UAV-based systems\nrepresent a promising tool for capturing outdoor interference from private 5G\nsystems.\n
Development of the Crohnʼs disease digestive damage score, the Lémann score (2010)

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lémann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage.
Physical Waveform Optimization for Multiple-Beam Multifunction Digital Arrays (2018)

The co-design of multiple RF functions provides the means to efficiently use the resources available for transmission (i.e. time, frequency, space, and power). Digital array technology supports simultaneous control over all domains of diversity through independent generation of the waveform emitted by each antenna element. The Far-field Radiated Emission Design (FFRED) formulation considers the efficient use of all available resources by simultaneously performing multiple functions in the same frequency band via spatially separated beams. The waveforms in the FFRED problem are constrained to have attractive signal properties via reduction in peak-to-average power ratio (PAPR) to increase power efficiency. This design constraint is shown to leverage the spatial orthogonal complement to the desired transmission directions so as to not interfere with the RF functions. Here, the FFRED problem is formulated as a gradient-based optimization with reduced computational complexity relative to the previous alternating projection implementation. For a certain initialization, the optimized waveforms are shown to be near-optimal in terms of minimal energy within the orthogonal complement.
Data from Molecular Mechanisms of Liver Carcinogenesis in the Mdr2-Knockout Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;Mouse models of hepatocellular carcinoma (HCC) simulate specific subgroups of human HCC. We investigated hepatocarcinogenesis in Mdr2-knockout (Mdr2-KO) mice, a model of inflammation-associated HCC, using gene expression profiling and immunohistochemical analyses. Gene expression profiling showed that although Mdr2-KO mice differ from other published murine HCC models, they share several important deregulated pathways and many coordinately differentially expressed genes with human HCC data sets. Analysis of genome positions of differentially expressed genes in liver tumors revealed a prolonged region of down-regulated genes on murine chromosome 8 in three of the six analyzed tumor samples. This region is syntenic to human chromosomal regions that are frequently deleted in human HCC and harbor multiple tumor suppressor genes. Real-time reverse transcription-PCR analysis of 16 tumor samples confirmed down-regulation of several tumor suppressors in most tumors. We show that in the aged Mdr2-KO mice, cyclin D1 nuclear level is increased in dysplastic hepatocytes that do not form nodules; however, it is decreased in most dysplastic nodules and in liver tumors. We found that this decrease is mostly at the protein, rather than the mRNA, level. These findings raise the question on the role of cyclin D1 at early stages of hepatocarcinogenesis in the Mdr2-KO HCC model. Furthermore, we show that most liver tumors in Mdr2-KO mice were characterized by the absence of β-catenin activation. In conclusion, the Mdr2-KO mouse may serve as a model for β-catenin–negative subgroup of human HCCs characterized by low nuclear cyclin D1 levels in tumor cells and by down-regulation of multiple tumor suppressor genes. (Mol Cancer Res 2007;5(11):1159–70)&lt;/p&gt;&lt;/div&gt;
Double High-dose Chemotherapy with Autologous Stem Cell Transplantation in Patients with High-risk Neuroblastoma: A Pilot Study in a Single Center (2002)

Double high-dose chemotherapy (HDCT) was applied to 18 patients with highrisk neuroblastoma including 14 patients who could not achieve complete response (CR) even after the first HDCT. In 12 patients, successive double HDCT was rescued with peripheral blood stem cells collected during a single round of leukaphereses and in 6 patients, second or more rounds of leukaphereses were necessary after the first HDCT to rescue the second HDCT. The median interval between the first and second HDCT (76 days; range, 47-112) in the single harvest group was shorter than that (274.5 days; range, 83-329) in the double harvest group (p<0.01). Hematologic recovery was slow in the second HDCT. Six (33.3%) treatment-related mortalities (TRM) occurred during the second HDCT but were not related to the shorter interval. Disease-free survival rates at 2 years with a median follow-up of 24 months (range, 6-46) in the single and double harvest group were 57.1% and 33.3%, respectively. These results suggest that successive double HDCT using the single harvest approach may improve the survival of high-risk patients, especially who could not achieve CR after the first HDCT despite delayed hematologic recovery and high rate of TRM during the second HDCT.
Real-time, Near-Infrared Fluorescence Imaging with an Optimized Dye/Light Source/Camera Combination for Surgical Guidance of Prostate Cancer (2014)

These data indicate that a NIR-emitting fluorophore targeted to PSMA may allow improved surgical treatment of human prostate cancer, reduce the rate of PSMs, and alleviate the need for adjuvant radiotherapy postoperatively.
3D spatial resolution enhancement through environmental effects with the time reversal operator decomposition (2003)

Time reversal operator (TRO) decompositions are performed in a wave-guide using different kinds of bottom. The purchase objective is to study the effects of bottom reverberation and absorption by mean of ultrasonic experiments. Amplitude compensation is proposed to improve the resolution of the system and signal to noise ratio at the target. Time dependent reverberation eigenvectors are back propagated in the medium and the conditions of focus on the bottom are discussed. A 3D-TRO is also constructed using an original array configuration which takes huge advantage of the multipath propagation in the wave-guide and allows selective multi target 3D-detection. The results could be used to increase echo levels in shallow water active detection or mine countermeasures.
Emerging Technologies in Patient Monitoring (2012)

The healthcare systems in the developed countries are changing rapidly. This is driven by socio-economic developments related to the aging population, the aggravating healthcare costs and the expected shortage of medical staff. These challenges might be – partially – addressed by more autonomous and intelligent patient monitoring with a trend to extend monitoring to lower acuity settings in hospitals or even at home. Currently technology options become available for patient monitoring and more integrated in our daily-lives, which have been originally developed for the consumer market such as miniaturized cameras, smart phones and tablet PC. This opens a wide range of opportunities for personal care, optimised privacy, comfort and family bonding.
Self-Organized Hexagonal Nanostructures on Nickel and Steel Formed by Anodization in 1-Butyl-3-methylimidazolium bis(triflate)imide Ionic Liquid (2014)

The formation of ordered hexagonal nanostructures with the size of 50–120 nm at the electrode surface has been studied in the course of electrochemical polishing of nickel and steel in the hydrophobic ionic liquid 1-butyl-3-methylimidazolium bis(triflate)imide. Optimal conditions favorable for the formation of such ordered structures have been revealed under the galvanostatic regime (I = 8 mA·cm–2; t = 10 min) and potentiostatic mode of operation (E = 3.0–3.2 V; t = 40 min). A theoretical background behind the generation of the hexagonal nanostructures has been proposed.
Expression, crystallization and preliminary crystallographic data analysis of filamin A repeats 14–16 (2007)

Human filamin A is a 280 kDa protein involved in actin-filament cross-linking. It is structurally divided into an actin-binding headpiece (ABD) and a rod domain containing 24 immunoglobulin-like (Ig) repeats. A fragment of human filamin A (Ig repeats 14-16) was cloned and expressed in Escherichia coli and the purified protein was crystallized in 1.6 M ammonium sulfate, 2% PEG 1000 and 100 mM HEPES pH 7.5. The crystals diffracted to 1.95 A and belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 50.63, b = 52.10, c = 98.46 A, alpha = beta = gamma = 90 degrees.
Performance evaluation of disk-type membrane separator for donation plasmapheresis. (1986)

世界の25%の血漿製剤を消費している我が国では血漿の確保が急務となっている.これに対して近年膜による血漿分離法が急速に発展してきており, 自己免疫疾患患者に対して臨床応用されるに至っている.本研究ではこの膜分離技術を血漿採取に応用することを考え, 入手した小型の円盤型血漿分離器の性能を検討するとともに, 血漿採取に必要な至適分離器形状を確立することを目的とした.供給液としてウシ血液を用いた濾過実験を行い, 供給血液の膜面剪断速度 (γω), 血球体積分率 (Hb) を広範囲に変化させたところ, 次式に示す濾過流束 (Jv) の式をモジュール円周方向の距離rの関数で表すことができた.Jv (r) =1.56×10-9γω (r) /r1/3ln (1.48/Hb (r)) この実験結果をもとに血漿採取条件 (1800sで4×10-4m3の血漿を採取) を満たす至適形状について模索したところ, 膜面積は最低0.15m2以上必要で, 各々の膜面積に対するモジュール円周方向の長さ, 流入部内径, 血液層高さ, 層数を求めることが可能となった.
Improved Synthesis and Corrosion Properties of Poly(bis-(dialkylamino)phenylene vinylene)s (BAMPPV) (2003)

An alternative material for corrosion protection on 2024 T3 aluminum alloy in aqueous alkaline environments has been synthesized and tested. The alternative material is a poly(phenylene vinylene) derivative called poly(bis-(N-methyl-N-hexylamino)phenylene vinylene) (BAMPPV). The synthesis of this material is discussed including improvements in overall yield of polymer and reduction in the side products. The BAMPPV was coated onto 2024 T3 Al alloy plates using a draw down method and an atomization and flame deposition process. The material has performed well in both neutral and alkaline (pH=8) environments and has shown excellent adhesion to the 2024 T3 aluminum alloy. A comparison of panels coated with BAMPPV to panels coated with chromate conversion coatings using B117 salt-fog tests (pH=7) showed similar performance results.
Interpretation of Wall-mounted Probe Characteristics in Hall Thrusters (2008)

Wall-mounted Langmuir probes are a promising internal diagnostic for Hall thrusters that can help understand critical plasma-wall interactions.However, the non-ideal environment within the discharge channel can complicate the implementation and interpretation of resulting probe characteristics.The effects of magnetic field and flowing plasma are experimentally investigated on a boron nitride coupon instrumented with a wall-mounted probe and placed in the far-field plume of a Hall thruster.Magnetic field settings were varied from 0 -200 G, and orientations of 0 -90 degrees were tested.Typical plasma number densities measured were around 3×10 14 m -3 , while electron temperatures were around 1.5 eV.The ratio between cyclotron radius and the Debye length ranged from 0.3 to 11, allowing comparisons to be made between this experiment and typical Hall thruster conditions where this ratio ranges from 10-15.It was found that magnetic field and ion flow angle effects were negligible for all orientations except 90° (parallel to the wall).Based on the results, it is concluded that magnetic fields likely have a negligible effect on measured properties, but the effects of ion flow and magnetic field oriented parallel to the wall requires further investigation.
The Development of Dioptric Projection Lenses for DUV Lithography (2002)

Most advanced refractive optical designs from Carl Zeiss are the basis of lenses for DUV microlithography, providing a resolution of better than 100nm across the full image field of a state-of-the-art scanner. However, in the design process towards implementing maximum numerical apertures and increasingly short wavelengths, many design and technology advances achieved in many years design experience at Carl Zeiss have been incorporated.The history of these designs goes back to the year 1902 -exactly 100 years ago - when Moritz von Rohr calculated the first monochromatic UV micro-objectives at Carl Zeiss for ultra-high resolution microphotography conducted by means of a line-narrowed UV light source.