gebhart/patrepeval huggingface dataset:
Distance Surface for Event-Based Optical Flow (2020)

We propose DistSurf-OF, a novel optical flow method for neuromorphic cameras. Neuromorphic cameras (or event detection cameras) are an emerging sensor modality that makes use of dynamic vision sensors (DVS) to report asynchronously the log-intensity changes (called "events") exceeding a predefined threshold at each pixel. In absence of the intensity value at each pixel location, we introduce a notion of "distance surface"-the distance transform computed from the detected events-as a proxy for object texture. The distance surface is then used as an input to the intensity-based optical flow methods to recover the two dimensional pixel motion. Real sensor experiments verify that the proposed DistSurf-OF accurately estimates the angle and speed of each events.
Synthesis of 2-(4-nitroaryl)propionate esters (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-(4-nitroaryl)propionate estersG. Patrick Stahly, Barbara C. Stahly, and Kenneth C. LiljeCite this: J. Org. Chem. 1984, 49, 3, 578–579Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/jo00177a048https://doi.org/10.1021/jo00177a048research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Electron Microscopy of Small Particles (1985)

A new approach to the characterization of small particles using several electron microscope techniques is outlined. A new high resolution microscope equipped with a TV-pickup system, which Is operated under an ultra-high vacuum, Is proved to be useful for examining individual small particles. Single crystal structure analysis on individual particles of γ-alumina is de scribed. By applying this high resolution electron microscope technique to small particles, their surface structures are observed at atomic resolution. The technique is utilized to examine sintered alumina powders and a hetero geneous catalyst. Structural Instability of gold clusters around 20 Å in size is seen through a TV-pickup observation system.
A Phase 2, Randomized, Double-blind, Placebo-controlled Study of oral RP7214, a DHODH inhibitor, in Patients with Symptomatic Mild SARS-CoV-2 Infection (2023)

Abstract Introduction COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of immense global public health concern. RP7214, a novel, potent, oral, inhibitor of DHODH, has shown preclinical evidence in inhibiting viral replication and lung inflammation. Methods This was a randomized, double-blind, placebo-controlled phase 2 study in patients with symptomatic mild SARS-CoV-2 infection, having at least one high-risk feature (e.g., hypertension, diabetes mellitus) for developing severe Covid-19 infection. The patients received RP7214 (400 mg BID) or a placebo for 14 days in a blinded fashion and were followed up to 30 days. Patients also received supportive therapy (e.g., antipyretics and antitussives for symptomatic relief) at the discretion of the investigator. The endpoints were Covid 19 related hospitalization rate by Day 15, SARS-CoV-2 viral load and clearance on Days 3,7 and 15, clinical symptoms improvement by Day 15, safety, and the immuno-modulatory effect of RP7214. Results A total of 163 patients were treated in the study; 82 received RP7214 and 81 received placebo. Of the total patients, 44.2% had received Covid-19 vaccine prior to the study. The symptom onset was ≤ 3 days in 22.1%. None of the patients in the study required hospitalization. There was no difference in the mean change of viral load between RP7214 and placebo. In the subgroup analysis, in patients having symptom onset of ≤ 3 days, RP7214 significantly reduced viral load on Days 3 and 7, respectively. Similarly, in non-vaccinated patients with symptom onset of ≤ 3 days, RP7214 significantly reduced viral load on Day 3. Overall, there was a trend towards better viral load reduction in RP7214-treated patients with a baseline viral load of 5 log units or higher. For all other endpoints, there was no difference between RP7214 and placebo. Majority of the reported AEs were mild and not related either to study treatment. Conclusions RP7214 at 400 mg BID dose level showed a statistically significant reduction in viral load at an early stage of the disease and in non-vaccinated patients. There was a trend towards better viral load reduction in RP7214-treated patients with a baseline viral load of 5 log units or higher. RP7214 showed a favorable safety profile. Further development of RP7214 in Covid 19 in a mild symptomatic population with co-morbidities and treated at an early stage of disease may show benefit.
Erratum: Two-dimensional nuclear magnetic resonance in rotating solids: An analysis of line shapes in chemical shift-dipolar spectra [J. Chem. Phys. 7 6, 2848 (1982)] (1982)

First Page
Cooperative Transmit Diversity via Superpostion Coding (2005)

We propose a new strategy for cooperative transmit diversity based on superposition modulation and multiuser detection. The new scheme can outperform "classical" cooperative diversity based on decode-and-forward by about 1.5-2 dB in the SNR range of interest, and at the same computational complexity
Abstract A138: Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK) (2009)

Abstract The cellular response to DNA double-strand break (DSB) formation is an essential component of normal cell survival, following exposure to DNA-damaging chemicals and ionising radiation. The serine/threonine kinase DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol (PI) 3-kinase related kinase (PIKK) family of enzymes, and plays an important role in DNA DSB repair via the non-homologous end-joining (NHEJ) pathway. DNA-PK inhibitors may, therefore, be useful as agents to improve the activity of radio- and chemo-therapy in the treatment of cancer. Identification of the lead benzo[h]chromen-4-one DNA-PK inhibitor NU7026 (IC50 = 0.23 uM) guided the development of the potent and selective ATP-competitive chromenone NU7441 (DNA-PK IC50 = 30 nM). Structure-activity relationship studies for DNA-PK inhibition by chromenone-derivatives were conducted in conjunction with homology modelling. Library synthesis was undertaken employing a solution multiple-parallel approach, by O-alkylation or N-acylation of the appropriately substituted NU7441 derivatives, respectively, followed by reaction with a range of amines to afford the target compounds. These studies resulted in the identification of KU-0060648, which combines high potency as a DNA-PK inhibitor (IC50 = 8.6 nM) with good aqueous solubility as an acid salt. The further development of KU-0060648 and analogues will be described. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):A138.
Nanoscale self-assembly of high-efficiency copper indium gallium selenide photovoltaic thin films (2009)

We demonstrate photovoltaic integrated circuits (PVIC) with high-quality large-grain Copper Indium Gallium
Selenide (CIGS) obtained with the unique combination of low-cost ink-based or Physical Vapor Deposition (PVD)
based nanoengineered precursor thin films and a reactive transfer printing method. Reactive transfer is a two-stage
process relying on chemical reaction between two separate precursor films to form CIGS, one deposited on the
substrate and the other on a printing plate in the first stage. In the second stage, these precursors are brought into
intimate contact and rapidly reacted under pressure in the presence of an electrostatic field while heat is applied.
The use of two independent thin films provides the benefits of independent composition and flexible deposition
technique optimization, and eliminates pre-reaction prior to the synthesis of CIGS. High quality CIGS with large
grains on the order of several microns, and of preferred crystallographic orientation, are formed in just several
minutes based on compositional and structural analysis by XRF, SIMS, SEM and XRD. Cell efficiencies of 14%
and module efficiencies of 12% have been achieved using this method. When atmospheric pressure deposition of
inks is utilized for the precursor films, the approach additionally provides further reduced capital equipment cost,
lower thermal budget, and higher throughput.
Effect of EGR on Homogeneous Charge Compression Ignition Combustion at Different Compression Ratios (2012)

The HCCI engine has attracted for high efficiency and low exhaust emissions. However, the HCCI combustion process has two issues to be resolved : ignition timing control, slower combustion. In order to overcome these issues, it is necessary to investigate in detail the low-temperature oxidation reactions that distinctly characterize HCCI combustion and the state of combustion. In this study, spectroscopic measurements were made at a high compression ratio of approximately 15:1, which is sufficiently high for practical operation. Simultaneously, the combustion condition in the cylinder was visualized via a sapphire observation window that was provided in the top of the cylinder head by taking advantage of the simple structure of the two-stroke test engine. The results revealed that the ignition delay period and the manner in which autoignition occurred tended to differ at different compression ratios when EGR was applied, which is believed to be effective in moderating HCCI combustion.
Bioconjugation by Native Chemical Tagging of C–H Bonds (2013)

A general C–H functionalization method for the tagging of natural products and pharmaceuticals is described. An azide-containing sulfinate reagent allows the appendage of azidoalkyl chains onto heteroaromatics, the product of which can then be attached to a monoclonal antibody by a “click” reaction. This strategy expands the breadth of bioactive small molecules that can be linked to macromolecules in a manner that is beyond the scope of existing methods in bioconjugation to permit tagging of the “seemingly untaggable”.
Bandgap dependence of band-to-band tunneling and defect-mediated excess currents in SiGe/Si heterojunction tunnel diodes grown by RTCVD (2009)

There is great interest in SiGe/Si heterojunction tunnel diodes for novel devices such as sharp subthreshold slope MOSFET's. High tunneling current densities are a clear goal (for MOSFET drive current, e.g.). This work presents two clear results: (i) a direct measurement of the dependences on bandgap (Ge fraction) of the direct tunneling current vs. the "excess" defect-assisted tunneling current, and (ii) the highest direct tunneling currents (NDR current peaks) observed in Si-based heterojunction diodes grown by chemical vapor deposition. In summary, we have shown SiGe/Si tunnel diodes with high peak current density and a clear trend of more dominant band-to-band tunneling over excess current as bandgap is reduced.
Regional susceptibility of the default mode network is associated with clinical phenotypes of Alzheimer's disease (2019)

Alzheimer's disease (AD) is characterized by heterogeneous clinical phenotypes, which present distinct tau-pathology patterns. The posterior default mode network (pDMN) seems, however, to be similarly affected by tau-pathology across clinical phenotypes. In this study, we investigated whether the tau-peaks in the pDMN of AD variants are associated with different functional connectivity networks.
Input Harmonic Sensitivity in High-Efficiency GaN Power Amplifiers (2018)

This paper presents the impact of input non-linearity and its dependence to output loading conditions in the design of Gallium Nitride (GaN) based Power Amplifiers (PAs). The drain efficiency variation due to the input non-linearity for any arbitrary second harmonic loading condition is presented. The theory presents generalized current waveform equations as a function of conduction angle (α) and input harmonic non-linearity (γ2). Thereafter, to quantify the impact of source harmonics, a systematic methodology to evaluate the efficiency degradation is proposed. For practical validation, the active load pull (ALP) experiments are carried out using a 0.7 mm GaN die by NXP at 2.6 GHz. The drain efficiency variation as a function of second harmonic load reactance has been measured and reported at P3dB gain compression. While, class B, and class F shows 5-6% drain efficiency variation to second harmonic source pull, class F <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , and class ∧Ĵ/∧Ĵ* shows immunity to the input non-linearity with only 1-2 % drain efficiency variation.
Uso de secoiridoides para el tratamient o la prevención de enfermedades inflamatorias inmunomediadas (2020)

Uso de secoiridoides para el tratamiento o la prevención de enfermedades inflamatorias inmunomediadas. La presente invención se refiere al uso de secoiridoides, tales como oleaceína y oleocantal, para prevenir o tratar enfermedades que provocan alteraciones gastrointestinales inmunomediadas. Además, la presente invención se refiere a una composición farmacéutica o composición nutracéutica que comprende dichos secoiridoides.
Correlation of securin and Ki67 in invasive breast carcinoma. (2019)

The present results suggest that securin may add to the prognostic value of ki67 in highlighting intra-tumoural heterogeneity in invasive breast carcinoma patients with poor clinical outcome. In addition, the study showed that since securin has a visual counting cutoff with more than 1%, making it easier to use as a breast cancer biomarker in conjunction with ki67 to predict the outcome of the cases more accurately than using only ki67. However, a multivariate analysis on a larger cohort of patients is mandatory to test its potential prognostic value.
Experimental and theoretical study of ultraviolet-induced structural/optical instability in nano silicon-based luminescence (2018)

Nano silicon is emerging as an active element for UV applications due to quantum confinement-induced widening of the Si bandgap, amenability to integration on Si, and less sensitivity to temperature. NanoSi-based UV applications include deep space exploration, high temperature propulsion, solar photovoltaics, and particle detection in high energy accelerators. However, the viability of the technology is limited by a complex nanoSi optical quenching instability. Here, we examined the time dynamics of UV-induced luminescence of sub 3-nm nanoSi. The results show that luminescence initially quenches, but it develops a stability at ∼50% level with a time characteristic of minutes. Upon isolation, partial luminescence recovery/reversibility occurs with a time characteristics of hours. To discern the origin of the instability, we perform first principles atomistic calculations of the molecular/electronic structure in 1-nm Si particles as a function of Si structural bond expansion, using time dependent density functional theory, with structural relaxation applied in both ground and excited states. For certain bond expansion/relaxation, the results show that the low-lying triplet state dips below the singlet ground state, providing a plausible long-lasting optical trap that may account for luminescence quenching as well as bond cleavage and irreversibility. Time dynamics of device-operation that accommodates the quenching/recovery time dynamics is suggested as a means to alleviate the instability and allow control of recovery, which promises to make it an effective alternative to UV-enhanced Si or metal-based wide-bandgap sensing technology.
Implementation of a Shock and Vibration Mitigation Process: Achieving Real-Time Solutions and Savings (2007)

Abstract Worldwide the costs associated with the exploration and production of oil have increased at a nearly exponential rate. This sharp rise in daily costs has also led to a new urgency from operators to find more reliable and efficient ways of doing business. Shock and vibration (S&amp;V) are the leading cause of failure for measurements-while-drilling (MWD) and rotary steerable systems (RSS) today. These failures have a major impact on operators and service companies, costing millions of dollars in repairs and hours of rig time. A wide variety of service companies now offer lateral, axial, and transverse shock measurements, as well as downhole revolution per minute (RPM) readings to better understand downhole dynamics. These measurements in the best of cases offer a reactive method of drilling, and at the worst provide no help in solving the problem or preventing damages to the bottom hole assembly (BHA). For shock and vibration measurements to be effective, operators and service companies need to work together to create a comprehensive process to include each phase of drilling: planning, execution, and evaluation. A shock and vibration standard combined with increased client awareness and education have allowed a new level of success to be set at the rig site. Now, shock and vibration issues at the rig can be flagged in real-time and monitored remotely from an operations support center (OSC). This communication structure, coupled with pre-job planning and modeling and the capture of post run lessons learned, can be used to offer solutions when problems arise; thus preventing damage to the BHA, reducing rig non productive time (NPT), and improving the rate of penetration (ROP).
On maximizing the average capacity with interference alignment in a time varying channel (2016)

Interference alignment like techniques are promising in multiuser networks as they yield a high sum capacity and allow multiple users to communicate concurrently. As alignment of interference requires tight coupling to estimates of the channel, time variations in the channel lead to loss of capacity since estimates take time to make and communicate. Thus, the length of the data and training phase should be appropriately chosen so as to maximise the average capacity. In this paper we present a way to model the sum capacity achieved by interference alignment in a time varying wireless channel and show that in slowly changing channels, it is possible to maximise the average capacity using just the knowledge of the maximum Doppler frequency of the interferers. For a given training duration, We select the data phase duration to maximise the average capacity and show that our predicted average capacity strongly tracks the true average capacity using the optimized data phase duration. In high Doppler scenarios, we do not see a benefit from our scheme because the channel capacity has high variance and a first order description is no longer sufficient. We further propose that the receiver can adapt its beamweights using a least-squares technique and approach the instantaneous sum capacity of interference alignment.
Automated retinal imaging and trend analysis &ndash; a tool for health monitoring (2017)

Most current diagnostic devices are expensive, require trained specialists to operate and gather static images with sparse data points. This leads to preventable diseases going undetected until late stage, resulting in greatly narrowed treatment options. This is especially true for retinal imaging. Future solutions are low cost, portable, self-administered by the patient, and capable of providing multiple data points, population analysis, and trending. This enables preventative interventions through mass accessibility, constant monitoring, and predictive modeling.
The role of speech input in wearable computing (2002)

Speech recognition seems like an attractive input mechanism for wearable computers, and as we saw in this magazine's first issue, several companies are promoting products that use limited speech interfaces for specific tasks. However, we must overcome several challenges to using speech recognition in more general contexts, and interface designers must be wary of applying the technology to situations where speech is inappropriate.
Virtual Development for In-Vehicle Network Topology – A Case Study of CAN FD Physical Layer (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In-vehicle network communication is evolving faster speeds and higher performance capabilities, connecting the information possessed by ECU and sensors with the in-vehicle electronic systems which are continuing to develop. With the evolution of the complicated networks, it is becoming difficult to develop them without many verification of actual machine. On the other hand, as for the verification means required at the logic level or physical level for a network verification through ECU design, virtual verification in the whole vehicle is difficult due to speed increases and the sheer size of the system. Therefore, it is only applicable for systems which are limited to a domain or an area, and flexible and timely utilization would be difficult due to the changes in specifications. Our approach to provide for the further advancement of the electronics design is to build a simulation environment for the network topology verification with a physical layer and a network layer in the OSI reference model. This paper will explain the verification technique of the bus load in the network layer and the ringing in the physical layer used to arrive at the recommended in-vehicle network topology.&lt;/div&gt;&lt;/div&gt;
Therapeutic potential of protease-activated receptor-1 antagonists (2003)

The serine protease thrombin (EC 3.4.21.5) is central to the maintenance of haemostatic balance through its coagulant, anticoagulant and platelet activating properties. In addition, this enzyme affects numerous cellular responses in a wide variety of cells, such as cell proliferation, cytokine and growth factor release, lipid metabolism and tissue remodelling. A family of G-protein-coupled protease-activated receptors (PARs) mediates these cellular actions of thrombin. While thrombin can activate three of the four PAR family members, PAR-1 represents the primary thrombin-responsive receptor in human cells. The expression of PAR-1 in platelets, the vasculature and myocardium, in cells within atherosclerotic plaque and tissues after vascular injury, indicates that this receptor plays an important role during the response to tissue injury and associated inflammatory processes. With the development of PAR-deficient mice and small-molecule antagonists, it is now clear that intervening in processes mediated by PAR-1 presents a new approach to treating a variety of disorders dependent on thrombin generation, including thrombosis and restenosis. The full potential of PAR-1 antagonists has yet to be realised, but the promise of novel therapeutics that modulate receptor function rather than thrombin's proteolytic activity, provides an alternative and, perhaps, more desirable means to dampen the pathological effects of thrombin.