gebhart/patrepeval huggingface dataset:
Implant Plastic Surgery: A Review and Rationale (2004)

Implant dentistry has been established as a predictable treatment modality with high clinical success rates. Esthetic considerations of implant restorations have been gaining increased interest over the years. The role of periodontal plastic surgical procedures in the creation and maintenance of peri-implant soft tissue heights to facilitate better esthetics has become more popular. The available plastic surgery procedures and their clinical applications are reviewed in this article. Emphasis is placed on factors to consider for proper case selection and ideal treatment planning.
Synthesis, crystal structure, and cytotoxicity studies of titanacalix[4 and 8]arene complexes (2018)

Reaction of 5,11,17,23-tetra-tert-butyl-dihydroxy-26,28-bis(2-pentoxy)calix[4]arene (L(OH)2(Opentyl)2) with [TiCl4] afforded the dichlorotitanoacalix[4]arene complex [TiCl2L(O)2(Opentyl)2] (1) in good yield. Hydrolysis of 1 led to the isolation of the complex {[TiL(O)3(Opentyl)]2(μ-OH)(μ-Cl)} (2). Reaction of 5,11,17,23,29,35,41,47-p-tert-butyl-49,50,51,52,53,54,55,56-octapropoxycalix[8]arene (L'(Opropyl)8) with [TiCl4] in refluxing toluene afforded, following work-up, a 35 : 65 mixture (3) of the complex [Ti(NCMe)Cl]2[TiCl(μ-O)]2L' and the silicone grease derived complex [Ti(NCMe)Cl]2[Ti(μ-O)]2[OSi(CH3)2OSi(CH3)2O]L' in which the grease replaces two chloride ligands. The molecular structures of 1·2MeCN, 2·7¼MeCN, and 3·10MeCN have been determined. The complexes were studied using in vitro cell assays and were found to have CC50 values in the range 111-186 μM, i.e. they have low toxicity.
A Study of Synthetic Oversampling for Twitter Imbalanced Sentiment Analysis (2016)

International audience
Novel Solutions to Water Pollution (2013)

To prevent water pollution, effective safety measures should be employed that prevent point-source and nonpoint-source pollution. Green chemistry solutions should be employed, where possible. An effective way to deal with the water pollution problem is to use the least harmful ways to eliminate contaminants. Chromatography and separation chemistry offer a variety of interesting approaches to achieve these goals. Interesting examples of remediation have been provided to help correct arsenic contamination of groundwater, which affects nearly 200 million people worldwide. A variety of novel methods have been included for prevention and remediation of water pollution that entail radical reaction and utilization of nanoparticles.
Radiosynthesis of [11C]paclitaxel (2002)

Abstract [ 11 C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [ α ‐ 11 C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Self-Frequency Shift of Cavity Soliton in Kerr Frequency Comb (2014)

We show that the ultrashort cavity soliton in octave-spanning Kerr frequency comb generation exhibits striking self-adaptiveness and robustness to external perturbations, resulting in a novel frequency shifting/cancellation mechanism and gigantic dispersive wave generation in response to the strong frequency dependence of Kerr nonlinearity, Raman scattering, chromatic dispersion, and cavity Q. These observations open up a great avenue towards versatile manipulation of nonlinear soliton dynamics, flexible spectrum engineering of mode-locked Kerr frequency combs, and highly efficient frequency translation of optical waves.
Micromagnetic simulation of thermal ripple in thin films: “Roller-coaster” visualization (2003)

We present simulations of pulse-induced magnetization-rotation experiments in Permalloy. These lead to temporary domain formation (“thermal ripple”) and help to explain the time dependence of experimental results. To understand and visualize the motion, we find it very useful to exploit a mathematical isomorphism of this problem (in the limit Ms≫Hpulse) to the problem of a massive particle on a circular track (“roller coaster”). The height (gravitational potential energy) of this track is proportional to the Stoner–Wohlfarth energy. The fact that the resulting “precession” is really oscillation in a plane, and the fact that this oscillation overshoots the minimum-energy configuration (the inertia effect) are much more intuitive in the roller coaster picture than in the conventional “M precesses about the effective field” picture. Animated simulations of this behavior are available on the web (http://bama.ua.edu/∼visscher/mumag/).
Performance analysis of LTE enterprise femtocell using cooperative downlink transmission scheme (2011)

In this paper, we propose a cooperative transmission scheme (CTS) for system throughput enhancement in enterprise femtocell downlink systems. In our scheme, the user equipment (UE) is capable of receiving the desired signal from the serving femtocell base station (fBS) as well as from an adjacent fBS. Thus, the UE achieves an improved signal-to-interference ratio (SIR) by using two time synchronized signals. Performances of the proposed scheme are evaluated in terms of the call-level quality of service (QoS) (i.e., call blocking probability) and the packet-level QoS (i.e., outage probability). We first measure the resource utilization and call blocking probability for the downlink resources for various offered load in femtocell. Based on that, we obtain the outage probability and effective throughput of the system via computer simulations. Simulation results show that compared to the conventional scheme, the proposed scheme can reduce the UE's outage probability in the enterprise femtocell environment. In particular, a significant performance improvement can be achieved with the proposed CTS for UEs located at the cell edge.
Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates (2020)

Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring isolated mitochondria from mouse or human cells into primary or immortal mtDNA-deficient (ρ0) cells. Stable isolated mitochondrial recipient (SIMR) cells isolated in restrictive media permanently retain donor mtDNA and reacquire respiration. However, SIMR fibroblasts maintain a ρ0-like cell metabolome and transcriptome despite growth in restrictive media. We reprogrammed non-immortal SIMR fibroblasts into induced pluripotent stem cells (iPSCs) with subsequent differentiation into diverse functional cell types, including mesenchymal stem cells (MSCs), adipocytes, osteoblasts, and chondrocytes. Remarkably, after reprogramming and differentiation, SIMR fibroblasts molecularly and phenotypically resemble unmanipulated control fibroblasts carried through the same protocol. Thus, our MitoPunch "pipeline" enables the production of SIMR cells with unique mtDNA-nDNA combinations for additional studies and applications in multiple cell types.
Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α (2010)

Toll-like receptors (TLRs) recognize microbial/viral-derived components that trigger innate immune response and conflicting data implicate TLR agonists in cancer, either as protumor or antitumor agents. We previously demonstrated that TLR3 activation mediated by its agonist poly(I:C) induces antitumor signaling, leading to apoptosis of prostate cancer cells LNCaP and PC3 with much more efficiency in the former than in the second more aggressive line. The transcription factor hypoxia-inducible factor 1 (HIF-1) regulates several cellular processes, including apoptosis, in response to hypoxia and to other stimuli also in normoxic conditions. Here we describe a novel protumor machinery triggered by TLR3 activation in PC3 cells consisting of increased expression of the specific I.3 isoform of HIF-1 alpha and nuclear accumulation of HIF-1 complex in normoxia, resulting in reduced apoptosis and in secretion of functional vascular endothelial growth factor (VEGF). Moreover, we report that, in the less aggressive LNCaP cells, TLR3 activation fails to induce nuclear accumulation of HIF-1 alpha. However, the transfection of I.3 isoform of hif-1 alpha in LNCaP cells allows poly(I:C)-induced HIF-1 activation, resulting in apoptosis protection and VEGF secretion. Altogether, our findings demonstrate that differences in the basal level of HIF-1 alpha expression in different prostate cancer cell lines underlie their differential response to TLR3 activation, suggesting a correlation between different stages of malignancy, hypoxic gene expression, and beneficial responsiveness to TLR agonists.
Spectroscopy of Human Plasma for Diagnosis of Idiopathic Parkinson S Disease (2008)

Biospectroscopy of plasma may provide a rapid, minimally invasive and inexpensive chemical biomarker of idiopathic PD.
Electrophoresis of polyampholytes (1998)

We consider the motion and the deformation of Gaussian polyampholytes in free flow electrophoresis, i.e., in an applied external electric field. The electrophoretic mobility and the deformation of the chains are calculated in the linear regime, as functions of the charge distribution along the backbone and of the salt concentration. The results in salt-free solutions differ from those in solutions with a high concentration of salt even at the level of scaling laws. It is shown that in solutions with a high salt concentration, the electrophoretic mobility of a given polyampholyte strongly depends not only on its total charge but also on the details of the charge distribution along the chain. The very direction of motion can also depend on it. Indeed, even “neutral” polyampholytes, i.e., chains with equal number of positive and negative charges can move in an applied electric field. To demonstrate further these effects, we systematically compare the behavior of the linear and circular chains.
The Barrow Biomimetic Spine: effect of a 3-dimensional-printed spinal osteotomy model on performance of spinal osteotomies by medical students and interns (2019)

Our results support the conclusion that this 3D-printed spine model is an effective adjunct to help early surgical trainees understand the Schwab osteotomy grading scale. Participants who received the model in addition to the source manuscript demonstrated improved theoretical knowledge and better performance on practical tests of complex spinal osteotomies. Similar models are likely to have utility in surgical training programs and as patient education models.
A Study of Smoldering Conditions in Upholstery Fabrics Using Thermal Imaging (1998)

Thin, porous textile fabrics that are predominantly cellulosic in content are partic ularly prone to smoldering when exposed to a low energy, localized heat source such as a cigarette fire cone. A thermal imaging technique for measuring transient temper ature fields is used to study smoldering ignition in upholstery fabrics with a simulated cigarette source. A method is described for measuring dynamic surface temperature gradients. Empirical data are presented in terms of peak surface temperature and en closed area within specific isotherms. When the representative temperature in the smol dering zone is greater than 450°C, the smoldering spread is maintained. Cotton duck fabrics do not show the reported reduction in smoldering propensity with decreasing areal density and washing of alkali metal ions. In contrast, the results for upholstery fabrics do allude to a mitigation of smoldering propensity with a significant lowering of surface temperature and isothermal area measurements.
Annular core research reactor high flux neutron radiography facility (1990)

Sandia National Laboratories (SNL) has been performing neutron radiography since 1964. The radiography facilities have evolved from an aperture in a radiation exposure room in the now retired Sandia Engineering Reactor to a divergent collimator radiography facility adjacent to the core of the Annular Core Research Reactor (ACRR). The maximum thermal neutron flux achieved in these facilities has been limited to approximately 1 {times} 10{sup 7} n-cm{sup -2}-s{sup -1}. In order to perform high-resolution, real-time neutron radiography for transient events, higher neutron fluxes are required. In response to this need, Sandia is designing a new high-flux neutron radiography facility for the ACRR. The new facility uses the central irradiation cavity of the ACRR and consists of a collimator assembly, reactor control system, an experiment support structure, and an imaging system. This new facility is described in this paper. 2 refs., 2 figs.
Live Electro-Optic Imaging of Microwave Near-Fields via Ultra-Parallel Photonic Heterodyne (2007)

We present the first demonstration of fine Live Electro-optic Imaging (LEI) of electrical signals on a microwave circuit. Patterns of their electric-near-fields are lively depicted on a display screen with a rate as high as 20 frames per second. In this system, a sensing light beam is modulated by an electro-optic (EO) crystal plate with the electric near-fields applied, and its spatial pattern of EO modulation are detected by a two-dimensional photo-detector array, where the frequency of modulation is down-converted by photonic heterodyne of large-scale parallelism. A digital signal processor (DSP) is employed to extract the frequency component of interest and to make it animated on the display screen. As examples, we present motion pictures of electric field pattern data acquired by the system in a real-time manner.
Emergence of Fluoxetine-Resistant Variants during Treatment of Human Pancreatic Cell Cultures Persistently Infected with Coxsackievirus B4 (2019)

This study reports the antiviral activity of the drug fluoxetine against some enteroviruses (EV). We had previously established a model of persistent coxsackievirus B4 (CVB4) infection in pancreatic cell cultures and demonstrated that fluoxetine could clear the virus from these cultures. We further report the emergence of resistant variants during the treatment with fluoxetine in this model. Four independent persistent CVB4 infections in Panc-1 cells were treated with fluoxetine. The resistance to fluoxetine was investigated in an acute infection model. The 2C region, the putative target of fluoxetine antiviral activity, was sequenced. However, Fluoxetine treatment failed to clear CVB4 in two persistent infections. The resistance to fluoxetine was later confirmed in HEp-2 cells. The decrease in viral titer was significantly lower when cells were inoculated with the virus obtained from persistently infected cultures treated with fluoxetine than those from susceptible mock-treated cultures (0.6 log TCID50/mL versus 4.2 log TCID50/mL, <i>p</i> < 0.0001). Some previously described mutations and additional ones within the 2C protein were found in the fluoxetine-resistant isolates. The model of persistent infection is an interesting tool for assessing the emergence of variants resistant to anti-EV molecules. The resistance of EV strains to fluoxetine and its mechanisms require further investigation.
Electrostatic effects on funneled landscapes and structural diversity in denatured protein ensembles (2009)

The denatured state of proteins is heterogeneous and susceptible to general hydrophobic and electrostatic forces, but to what extent does the funneled nature of protein energy landscapes play a role in the unfolded ensemble? We simulate the denatured ensemble of cytochrome c using a series of models. The models pinpoint the efficacy of incorporating energetic funnels toward the native state in contrast with models having no native structure-seeking tendency. These models also contain varying strengths of electrostatic effects and hydrophobic collapse. The simulations based on these models are compared with experimental distributions for the distances between a fluorescent donor and the heme acceptor that were extracted from time-resolved fluorescence energy transfer experiments on cytochrome c. Comparing simulations to detailed experimental data on several labeling sites allows us to quantify the dominant forces in denatured protein ensembles.
Proceedings of the 4th international workshop on End-user software engineering (2008)

Welcome to the Fourth Workshop on End-User Software Engineering. WEUSE IV is a one-day workshop aimed at challenges faced in helping end users develop dependable software. WEUSE IV is structured around four themes. Each of the twenty short papers accepted to the workshop has overlap with one or more of the following themes: Empirical Evaluation in End-User Software EngineeringLearning from End UsersSoftware Engineering for End UsersEnd-User Tools for Creating Dependable Software Each theme will be introduced by a session lead who will set forth his or her vision in the theme area, taking into account relevant papers. Following each presentation, there will be ample time for discussion.
A simulation study on the simple chemical processes of fine particulate solids with distribution and reactivity (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simulation study on the simple chemical processes of fine particulate solids with distribution and reactivityMasataka Machida and Mamoru SennaCite this: J. Phys. Chem. 1988, 92, 6, 1514–1519Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/j100317a028https://doi.org/10.1021/j100317a028research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Single-beam spectrally encoded color imaging (2018)

We have developed, to the best of our knowledge, a new method of conducting spectrally encoded color imaging using a single light beam. In our method, a single broadband light beam was incident on a diffraction grating, where the overlapped third order of the red, fourth order of the green, and fifth order of the blue spectral bands were focused on a line illuminating tissue. This configuration enabled each point on the line to be illuminated by three distinctive wavelengths, corresponding to red, green, and blue. A custom grating was designed and fabricated to achieve high diffraction efficiencies for the wavelengths and diffraction orders used for color spectrally encoded imaging. A bench system was built to test the new spectrally encoded color imaging method. For a beam diameter of 174 μm, the bench system achieved 89,000 effective pixels over a 70° circular field. Spectrally encoded color images of excised swine tissue revealed blood vessels with a similar color appearance to those obtained via a conventional color camera. The results suggest that this single-beam spectrally encoded color method is feasible and can potentially simplify color spectrally encoded endoscopy probe designs.
Parallele Bestimmung der Aktivitäten von Creatinkinase und Creatinkinase-Isoenzym-MB zur Diagnose des akuten Myokardinfarktes (1979)

Article Parallele Bestimmung der Aktivitäten von Creatinkinase und Creatinkinase-Isoenzym-MB zur Diagnose des akuten Myokardinfarktes was published on January 1, 1979 in the journal Journal of Laboratory Medicine (volume 3, issue 9).
Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation (2001)

Allogeneic peripheral blood stem cell grafts contain about 10 times more T and B cells than marrow grafts. Because these cells may survive in transplant recipients for a long time, recipients of blood stem cells may be less immunocompromised than recipients of marrow. Immune reconstitution was studied in 115 patients randomly assigned to receive either allogeneic marrow or filgrastim-mobilized blood stem cell transplantation. Between day 30 and 365 after transplantation, counts of most lymphocyte subsets were higher in the blood stem cell recipients. The difference was most striking for CD4 T cells (about 4-fold higher counts for CD45RA(high) CD4 T cells and about 2-fold higher counts for CD45RA(low/-)CD4 T cells; P <.05). On assessment using phytohemagglutinin and herpesvirus antigen-stimulated proliferation, T cells in the 2 groups of patients appeared equally functional. Median serum IgG levels were similar in the 2 groups. The rate of definite infections after engraftment was 1.7-fold higher in marrow recipients (P =.001). The rate of severe (inpatient treatment required) definite infections after engraftment was 2.4-fold higher in marrow recipients (P =.002). The difference in the rates of definite infections was greatest for fungal infections, intermediate for bacterial infections, and lowest for viral infections. Death associated with a fungal or bacterial infection occurred between day 30 and day 365 after transplantation in 9 marrow recipients and no blood stem cell recipients (P =.008). In conclusion, blood stem cell recipients have higher lymphocyte-subset counts and this appears to result in fewer infections. (Blood. 2001;97:3380-3389)
Characterization of the ribonucleic acid primers and the deoxyribonucleic acid product synthesized by the DNA polymerase and gene 4 protein of bacteriophage T7. (1979)

The DNA polymerase and gene 4 protein of phage T7, in the presence of helix-destabilizing protein (DNA binding protein), catalyze DNA synthesis on duplex templates. As has been previously shown (Kolodner, R. D., and Richardson, C. C. (1978) 4. Biol. Chem. 253, 574-584), in the absence of ribonucleoside 5'-triphosphates DNA synthesis is initiated at nicks, and all of the newly synthesized DNA is covalently attached to the template. In this paper we characterize the DNA synthesized in the presence of ribonucleoside 5'-triphophates and show that, in contrast, the major portion of the newly synthesized DNA is not attached to the template, having an average chain length of 5000 to 6000 nucleotides. In addition, each chain of newly synthesized DNA is terminated at its 5'-end by a covalently attached tetranucleotide RNA primer whose sequence is predominantly pppApCpCpC and pppApCpCpA. The results of isotope transfer experiments are in agreement with the number of initiation events determined by the incorporation of [gamma-32P]ATP and indicate that each of the four deoxyribonucleotides is present at the RNA-DNA junction.