gebhart/patrepeval huggingface dataset:
Effects of Flame Structure and Hydrodynamics on Soot Particle Inception and Flame Extinction in Diffusion Flames (2001)

This paper summarizes recent studies of the effects of stoichiometric mixture fraction (structure) and hydrodynamics on soot particle inception and flame extinction in diffusion flames. Microgravity experiments are uniquely suited for these studies because, unlike normal gravity experiments, they allow structural and hydrodynamic effects to be independently studied. As part of this recent flight definition program, microgravity studies have been performed in the 2.2 second drop tower. Normal gravity counterflow studies also have been employed and analytical and numerical models have been developed. A goal of this program is to develop sufficient understanding of the effects of flame structure that flames can be designed to specifications - consequently, the program name Flame Design. In other words, if a soot-free, strong, low temperature flame is required, can one produce such a flame by designing its structure? Certainly, as in any design, there will be constraints imposed by the properties of the available materials. For hydrocarbon combustion, the base materials are fuel and air. Additives could be considered, but for this work only fuel, oxygen and nitrogen are considered. Also, the structure of these flames is designed by varying the stoichiometric mixture fraction. Following this line of reasoning, the studies described are aimed at developing the understanding of flame structure that is needed to allow for optimum design.
Ultrasonic Activation of Thermally Sensitive Liposomes (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Eleonora Mylonopouloua, Costas D. Arvanitisa, Miriam Bazan‐Peregrinoa, Manish Arora, Constantin C. Coussios; Ultrasonic Activation of Thermally Sensitive Liposomes. AIP Conference Proceedings 9 March 2010; 1215 (1): 83–87. https://doi.org/10.1063/1.3367202 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 (2010)

Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CENP-E) 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide (GSK923295; 1), starting from a high-throughput screening hit, 3-chloro-4-isopropoxybenzoic acid 2. Compound 1 has demonstrated broad antitumor activity in vivo and is currently in human clinical trials.
Controlled variation of boundary-activated ion fragmentation processes in a quadrupole ion trap (1994)

Fragmentation in a quadrupole ion trap of each of two isomeric molecular ions, obtained from 4-nitro-o-xylene and 4-nitro-m-xylene, has been investigated. It is demonstrated that the degree of fragmentation may be controlled by prolongation of both the duration for which the working point of the mass-selected species is held in the vicinity of a stability boundary and a prior collisional cooling period. The extent of fragmentation has been found to increase as the working point is held near the β z = 0 stability boundary while the relative abundances of fragment ions can be varied with the duration of the collisional cooling period. Under appropriate conditions for 4-nitro-o-xylene, &gt;94% of the isolated ions can be fragmented; &lt;5% of the ions are lost from the ion trap while 1% remain intact. As 99% of the charge of the fragmented ions is retained in the ion trap, the overall optimum efficiency of boundary-activated dissociation is &gt;93%; the corresponding efficiency for 4-nitro-m-xylene is 74%. 50% of the selected ions can be fragmented in ≤3 ms. The results are compared with collision-activated dissociation studies carried out with a triple stage quadrupole–hexapole–quadrupole instrument. This technique of boundary-activated dissociation provides a general procedure which does not require careful tuning of the instrument as is required for the more commonly-used technique of resonance excitation.
Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study (2021)

Carnosine affords protection against oxidative and carbonyl stress, yet high concentrations of the carnosinase-1 enzyme may limit this. We recently reported that high urinary carnosinase-1 is associated with kidney function decline and albuminuria in patients with chronic kidney disease. We prospectively investigated whether urinary carnosinase-1 is associated with a high risk for development of late graft failure in kidney transplant recipients (KTRs). Carnosine and carnosinase-1 were measured in 24 h urine in a longitudinal cohort of 703 stable KTRs and 257 healthy controls. Cox regression was used to analyze the prospective data. Urinary carnosine excretions were significantly decreased in KTRs (26.5 [IQR 21.4-33.3] µmol/24 h versus 34.8 [IQR 25.6-46.8] µmol/24 h; <i>p</i> < 0.001). In KTRs, high urinary carnosinase-1 concentrations were associated with increased risk of undetectable urinary carnosine (OR 1.24, 95%CI [1.06-1.45]; <i>p</i> = 0.007). During median follow-up for 5.3 [4.5-6.0] years, 84 (12%) KTRs developed graft failure. In Cox regression analyses, high urinary carnosinase-1 excretions were associated with increased risk of graft failure (HR 1.73, 95%CI [1.44-2.08]; <i>p</i> < 0.001) independent of potential confounders. Since urinary carnosine is depleted and urinary carnosinase-1 imparts a higher risk for graft failure in KTRs, future studies determining the potential of carnosine supplementation in these patients are warranted.
KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial (2023)

Compared with 1 year of imatinib, 3 years of adjuvant imatinib led to 66% reduction in the estimated risk of death and a high 10-year OS rate in the subset of patients with a KIT exon 11 deletion/indel mutation.
Os(ii) metal phosphors bearing tridentate 2,6-di(pyrazol-3-yl)pyridine chelate: synthetic design, characterization and application in OLED fabrication (2014)

Treatment of 2,6-di(5-trifluoromethylpyrazol-3-yl)pyridine (pz2py)H2 with Os3(CO)12 affords a mononuclear Os(II) complex [Os(pz2py)(CO)2(H2O)] (1) in excellent yield. Ligand substitution reactions were next executed to identify products with good photoluminescence at both fluid and solid states at RT. Therefore, substitutions with phosphorus donors such as PPh2Me and 2,6-bis(diphenylphosphinomethyl) pyridine (P2N), and nitrogen donors such as pyridine, 2,2′-bipyridine (bpy) and 2,2′:6′,2′′-terpyridine (tpy), afforded products with formula [Os(pz2py)(PPh2Me)2(CO)] (2), [Os(pz2py)(P2N)] (3), [Os(pz2py)(CO)2(py)] (4), [Os(pz2py)(CO)(bpy)] (5) and [Os(pz2py)(CO)(tpy)] (6). The single crystal X-ray structural analyses were executed on 1, 2, 3 and 6 to reveal the bonding of pz2py chelate as well as the structural effect imposed by the phosphorus and/or nitrogen donor groups. The photophysical properties were studied and discussed using the results of DFT and TDDFT calculations. For application, fabrication and analysis of organic light emitting diodes (OLEDs) were also carried out. OLEDs using 2 as a dopant exhibited an intense yellow emission with a maximum efficiency of 18.3%, 61.0 cd A−1, and 53.8 lm W−1, which are higher than those of most reported devices with greenish yellow/yellow emitters. Moreover, dopant 2 was combined with a red emitting dopant Os(bpftz)2(PPhMe2)2 (7) and two different sky-blue phosphors FIrpic and Ir(bptz)2(bdp) (8) to fabricate white OLEDs (WOLEDs). Device W1 achieved the highest efficiency of 18.0%, 33.9 cd A−1, and 31.2 lm W−1 while the maximized efficiency of device W2 was 15.3%, 29.3 cd A−1, and 27.0 lm W−1. Both devices showed stable warm-white emissions with a wide luminance range. In addition, device W2 exhibited a higher CRI of 84.2 with a low CCT of 2675 K at 103 cd m−2, making it a potential candidate for domestic lighting.
Locked-rotor test methods for induction motors investigated (2015)

Locked-rotor testing is a common end-of-the-line check performed on most motors used in the petrochemical industry. Despite its popularity as a verification of rotor integrity and to confirm the current draw and torque produced at zero speed, there can be much ambiguity in how the test is performed. This test is not required by the National Electrical Manufactures Association Motors and Generators standard (NEMA MG1) or the Institute of Electrical and Electronics Engineers Standard 112 (IEEE 112). IEEE 112 contains a locked-rotor test method, but there can be variations in the results based upon the test conditions (duration of voltage application and magnitude of applied voltage, for instance). The purpose of this paper is to describe how the test procedure employed affects the locked-rotor test results for both current and torque. Model and test data is presented to illustrate the variations possible depending on the test technique.
Microwave plasma-assisted silicon nanoparticles: cytotoxic, molecular, and numerical responses against cancer cells (2019)

Silicon nanoparticles (SiNPs), which have a special place in material science due to their strong luminescent property and wide applicability in various physicochemical arenas, such as solar cells and LEDs, were synthesised by a microwave plasma-assisted process using an argon-silane mixture. Several characterization tools were applied to check the crystallinity (XRD) and morphological (FESEM, TEM, ∼20 ± 2 nm size) and topographical (AFM, ∼20 nm) details of the NPs. The high-purity SiNPs were applied on myoblast cancer cells to investigate the reactivity of the NPs at different doses (200, 1000 and 2000 ng mL<sup>-1</sup>) for different incubation periods (24 h, 48 h & 72 h). The MTT assay was utilized to determine the percentage of viable and non-viable cells, while the cell organization was observed <i>via</i> microscopy and CLSM. Additionally, the molecular responses (RT-PCR), such as apoptosis, were analyzed in presence of caspase 3 and 7, and the results showed an upregulation with SiNPs. To validate the obtained data, analytical studies were also performed for the SiNPs <i>via</i> statistical analysis and the most reliable data values were evaluated and acceptable as per the ICH guidelines.
The Priming Effects Of Media Frames In Regard To News Images And Stereotypes Held By Hispanic Audiences (2013)

This study applies priming, framing, and exemplification theories to examine the ways in which photos published with a news story influenced readers’ judgments about the ethnicities of the people receiving emergency hunger services. Of particular interest were the perceptions of Caucasian respondents about minorities, and Hispanic perceptions about African Americans and other Hispanics. A sample of 506 college students was randomly assigned to read one of three versions of an online news article about emergency hunger services in Central Florida. One version included two photographs of African American adults receiving food at a food bank. The second version included two photographs of Hispanic adults receiving food at a food bank. The third version was text-only and included no photographs. All three articles included base-rate statistics of ethnicities using emergency hunger services. Results showed images influence the way Caucasians and Hispanics perceive those people suffering from hunger. Key findings included that Caucasians in the study were susceptible to Hispanic primes, which altered their views on their perceptions about the number of Hispanics receiving emergency food services. However, Caucasians’ perceptions of African Americans did not change. Additionally, Hispanic participants were affected by primes in such a way that limitations on societal advancement were perceived more strongly than those of the Caucasian participants. The difference between Caucasians’ stereotypes regarding African Americans and Hispanics is an interesting development. The role of priming stereotype in relation to social issues is discussed
Acute coronary occlusion and in-stent thrombosis in a patient with essential thrombocythemia (1998)

We describe a case of essential thrombocythemia in a 34-year-old male who presented with acute anterior wall myocardial infarction and a platelet count of 2,100,000/mm3. Primary percutaneous coronary angioplasty and stenting were performed. Postangioplasty course was complicated by stent thrombosis requiring repeat coronary angioplasty and persistent femoral arterial bleeding that was treated with surgical exploration and repair. The patient was subsequently treated with platelet pheresis, acetylsalicylic acid, ticlopidine, hydroxyurea, and anagrelide without further complications.
Reactions of sulfur fluorides and benzenes in a low temperature plasma (2000)

Sulfur fluorides SF6, ClSF5 and CF3SF5 were reacted with C6H6, C6H5Br and C6H5Cl in a low temperature radio-frequency plasma. Due to the stepwise dissociation of sulfur fluorides, the fluorination of benzenes was observed. In all reaction products C6H5SF5 was found in minor quantities, and BrC6H4SF5 or ClC6H4SF5 along with numerous halogenated benzenes when C6H5Br or C6H5Cl were used as reactants, respectively.
The Identification of Green Tea Based on Feature Extraction (2013)

In order to identify the green tea quickly and accurately, the infrared spectra of teas measured by Fourier transform infrared spectroscopy are analyzed by using informatics method of feature extraction in this work. By comparing the different characteristic bases found by different feature genes of different tea samples, it is concluded that when green tea, yellow tea and white tea are chosen to constitute the standardized spectrum data matrix, and its first and third feature gene are selected to build characteristic basis, the green tea can be visually distinguished and the same samples have a very good aggregation. While when the characteristic basis is built by the first and second feature gene or the second and third feature gene, or the samples which are used to make up of standardized spectrum data matrix are all green tea, the recognition effect of green tea is bad. A linear arbiter of green tea is set up according to neutrality line principle on the above effectively characteristic basis, when all samples are projected onto the characteristic basis it is shown that all the green tea fall on the right of arbiter, and all not green teas are on the left of arbiter, consequently, the green tea can be identified.
CRAWDAD dataset rice/midas (v. 2010-09-01) (2010)

Accelerometer and compass readings along with network usage and application data usage information from 11 smartphone users, each for one week in the field.
Test Schedule Optimization for Multicore SoCs: Handling Dynamic Voltage Scaling and Multiple Voltage Islands (2012)

In order to provide high performance with low power consumption, many multicore chips employ dynamic voltage scaling and voltage islands that operate at multiple power-supply voltage levels. Effective defect screening for such chips requires test applications at different operating voltages, which leads to higher test time and test cost compared to systems-on-a-chip (SoCs), which operate at only a single voltage level. We propose test scheduling techniques to minimize the testing time for multicore chips when each core is tested at multiple voltage levels and when it is tested for state retention when the core switches between two voltage levels. The proposed techniques include exact optimization based on integer linear programming and fast heuristic methods. Experimental results for two test-case SoCs from the industry highlight the effectiveness of the proposed method.
Experimental Studies on the Adsorption of Two Surfactants on Solid−Aqueous Interfaces:  Adsorption Isotherms and Kinetics (2008)

A quartz crystal microbalance with dissipation (QCM-D) was used to measure the adsorption from aqueous solutions of CTAB (cationic) and C(12)E(6) (nonionic) surfactants on gold and silica surfaces. QCM-D allows for the determination of adsorption isotherms and also the monitoring of the dynamics of adsorption in real time. By considering the atomic-scale roughness of the solid surfaces and the surface area per head group at the air/water interface, our experiments indicate that at bulk concentrations above the critical micelle concentration adsorbed C(12)E(6) forms a monolayer-like structure on both surfaces and CTAB yields a bilayer-like structure. Although our measurements do not allow us to discriminate between the morphology of the aggregates (i.e., between flat monolayers, hemicylinders, or hemispheres in the case of C(12)E(6) and between flat bilayers, cylinders, or spheres in the case of CTAB), these results are particularly significant when compared to recent QCM-D data reported by Macakova et al. (Macakova, L.; Blomberg, E.; Claesson, P. M. Langmuir 2007, 23, 12436). These authors reported that QCM-D overestimates the amount of CTAB adsorbed on silica by as much as 30-40% as a result of entrapped water. Our analysis suggests that the effect of entrapped solvent is not as important as previously assumed and, in fact, QCM-D may not overestimate the amount of CTAB adsorbed when roughness is considered. Results for the kinetics of adsorption suggest that the aggregate structure as well as whether micelles are present may influence the adsorption mechanism. We discuss our results in the perspective of molecular theories for both the equilibrium and kinetics of surfactant adsorption.
Digital chest radiography: effect on diagnostic accuracy of hard copy, conventional video, and reversed gray scale video display formats. (1988)

Observer performance tests were conducted to compare the effects on diagnostic accuracy of hard copy (film) versus video display and to determine the diagnostic merits of conventional negative ("white bone") versus positive ("black bone") video displays. Subjective preferences were elicited from each observer for each display modality, and diagnostic accuracy was determined with receiver operating characteristic analysis. Digitized chest radiographs were used, including normal and abnormal cases with a variety of subtle abnormalities. The hard copy was printed with a 1,024 X 1,024-matrix by a high-quality drum scanner in conventional white bone format only. The video images were displayed on a 1,023-line monitor (30 Hz, interlaced) in both white bone and black bone formats with fixed window and brightness settings. Most observers preferred hard copy to video, but preferences were sharply divided between white bone and black bone video. Diagnostic accuracy was significantly greater with hard copy than with video display, and the conventional white bone format was significantly superior in accuracy to the black bone display.
The Fhit protein: an opportunity to overcome chemoresistance (2016)

Since the very first moment of its discovery in 1996 [1], the FHIT (Fragile Histidine Triad) gene product appeared as a very intriguing molecule to be investigated in the pathogenesis of cancer. In fact, FHIT encompasses the most common fragile site in human [2], whose genetic alterations, leading to the loss of FHIT expression, have been reported in the majority of human cancers [3]. Other than genetic lesions, FHIT expression in both solid and hematopoietic malignancies is also impaired by its promoter hypermethylation [4, 5], making Fhit protein virtually completely lost in tumors. Moreover, several reports have intriguingly pointed to Fhit loss as a very early event in epithelial tumorigenesis (presumably, the earliest event in smoking-related lung cancer) [3].
Simultaneous integrin αβ and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty (2005)

Simultaneous inhibition of IIb/IIIa and alpha(v)beta(3) causes a marked reduction in infarct size in a model of acute coronary thrombosis and primary PTCA that is associated with reduced myocardial microthrombi and inflammation, as well as improved myocardial blood flow and regional function. These results may have important implications in the treatment of acute coronary syndromes.
DEVELOPMENT OF A TIE-DOWN SYSTEM FOR TEMPORARY CONCRETE BARRIERS (2002)

During construction of highways and bridges, it is common for temporary concrete barriers to be installed near the edge of a roadway or bridge deck during construction. Free-standing temporary barriers placed close to the bridge deck edge pose a major safety hazard to errant vehicles as there is a significant risk for the barrier segments to be propelled off of the bridge. Previous testing of temporary barriers has shown deflections of more than one meter. These large dynamic deflections, in combination with a narrow gap located behind the barriers, would prove sufficient to push the barriers as well as the impacting vehicle off of the bridge deck. In 1998, researchers at the Midwest Roadside Safety Facility at the University of Nebraska, Lincoln were approached to develop a tie-down system for this type of installation. This report details the development and testing of an NCHRP Report 350 compliant tie-down system for use with F-shape temporary concrete barriers. Development of the tie-down system began with the creation and evaluation of several design concepts. Following the researchers' evaluation of the design prototypes, the steel strap tie-down concept was selected for further study. This concept consisted of a steel strap that connected to the barrier joints and then bolted to the concrete bridge deck. The steel strap tie-down was analyzed and redesigned using LS-DYNA finite element computer simulation modeling. The strap tie-down is comprised of a 76-mm x 6.4-mm x 914-mm piece of ASTM A36 steel bent into a trapezoidal shape. Holes are punched in the plate to allow the connecting pin at the barrier joints to pass through the strap as well as allow the strap to be anchored to the bridge deck at each end. Anchoring of the strap to the bridge deck is done using two of 19-mm diameter drop-in anchors for each strap. The steel strap tie-down was bogie tested to evaluate its performance. One full-scale vehicle crash test, test no. ITD-1, was conducted according to Test Level 3 (TL-3) test no. 3-11 found in the NCHRP Report No. 350. The test consisted of a 2,012-kg pickup truck impacting the temporary barrier system at a speed of 97.6 km/h and at an angle of 24.3 deg. The impact occurred 1.2 meters upstream of the barrier joint. Results from the crash test showed that the system safely redirected the impacting pickup truck, and the test was judged to be successful according to the NCHRP Report No. 350 safety performance criteria. Based on the results of the NCHRP Report No. 350 compliance test, it is recommended that this design be approved for use on Federal-aid highways. Recommendations for proper application of the new design are also given.