gebhart/patrepeval huggingface dataset:
Higher order logic (1994)

Combination of evaporative drying and frozen storage at -80 degrees C has been used successfully to preserve hybrid B6D2F1 mouse spermatozoa. To determine whether this method can be applied equally well to inbred mice, spermatozoa of C57BL/6J and FVB/ NJ mice were evaporatively dried and stored for 1 mo at -80 degrees C before being used for intracytoplasmic sperm injection (ICSI) to produce live offspring. After weaning, 1 male and 1 female mouse from each litter were randomly selected at 8 wk of age for natural mating to produce live offspring. Results showed that spermatozoa from both inbred strains that had been evaporatively dried and subsequently stored at -80 degrees C could be used successfully to derive live, healthy, and reproductively sound offspring by ICSI. No significant differences were found in embryo transfer rate (number of pups born/number of embryos transferred), litter size, weaning rate, body weight, number of pathologic lesions, and amount of contamination by pathogens of mice produced by ICSI using evaporatively dried spermatozoa compared with mice produced by natural mating or by ICSI using fresh (that is, nonpreserved) spermatozoa. Progeny produced by mating mice generated from ICSI using evaporatively dried spermatozoa were normal. Therefore, spermatozoa from inbred mouse strains C57BL/6J and FVB/NJ can be preserved successfully after evaporative drying and frozen storage at -80 degrees C.
Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants (2023)

PK/PD models well characterized the time course of immune system markers in healthy adults. Our results supported sex and race as covariates on JNJ-4964 responsiveness, as well as circadian rhythms and negative feedback as homeostatic mechanisms that are relevant in TLR7-induced type I IFN responses.
Inhibition of growth of tumors derived from MCF-7 cells and MCF-7 cells overexpressing steroid sulfatase by STX64 and STX213 (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4706 

Breast cancer in women is of major concern and urgently requires new treatment strategies. High levels of estrogens, found in peripheral tissue, play a significant role in the development of post menopausal breast cancer. There are two main pathways by which estrogens can be synthesised in peripheral tissues, either via the aromatase and/or sulfatase routes. Steroid sulfatase (STS) inhibitors that can decrease or prevent the biosynthesis of estrogens via the sulfatase route may have an important role in the treatment of breast cancer. This work shows the in vivo efficacy in a dual xenograft breast cancer model of two potent STS inhibitors, STX64 and STX213. MCF-7 cells stably expressing STS cDNA (MCF-7[sts]) were generated in-house, with STS activity in these cells being 15 fold higher than in wild type MCF-7 (MCF-7[wt]). Ovariectomised MF-1 female nude mice (nu-/nu-) received subcutaneous (s.c.) injections of estradiol sulfate (E2S) at 0.05mg/0.05ml/mouse 24 hr prior to cell injection. Five million wild type MCF-7[wt] or MCF-7[sts] cells were injected s.c., in Matrigel, into the left and right flanks of the animal respectively. E2S was injected s.c. on alternative days until the end of the study. When tumors reached 100mm3 mice were divided into four groups: vehicle (10% THF:90% PG), STX64 (10mg/kg or 20mg/kg), or STX213 (10mg/kg) treatment. All compounds were given orally for 5 days a week for 49 days. A tumor recovery period of 35 days was then observed during which animals received E2S but no drug treatment. Mice were weighed and tumor measurements taken on a weekly basis. At the end of the study tumors, liver, lung and skin were removed for measurement of STS activity. Both tumors only grew in the presence of the E2S supplement. In the control group tumor volumes increased to 527 ± 87% for MCF-7\[wt] and 377 ± 123% for MCF-7[sts\] (mean ± SEM) after 49 days compared to week zero. MCF-7[wt] tumor growth was reduced by both STX64 at 20 mg/kg (361 ± 95%) and STX213 (230 ± 123.4%) over the dosing period and subsequent growth was retarded over the recovery period. All treatments were able to significantly inhibit E2S-induced growth of MCF-7[sts] tumors (by 70 to 90% in all treatments), and regrowth of these tumors was also significantly retarded (p < 0.001). Furthermore, all treatments completely inhibited tissue STS activity. No weight loss was observed with any treatment over the entire dosing period. In conclusion, this study indicates that STS inhibitors attenuate breast cancer growth in rodents and therefore offer a potentially novel treatment against breast cancer.
Suppression of interleukin 2 receptor acquisition by monoclonal antibodies recognizing the 50 KD protein associated with the sheep erythrocyte receptor on human T lymphocytes. (1985)

Monoclonal antibodies OKT11A, 9.6, and 35.1 recognize epitopes on a 50000 dalton surface molecule (p50) identical to or closely associated with the sheep erythrocyte receptor (E receptor) on human T lymphocytes. These three antibodies were investigated for ability to inhibit T cell proliferation and interleukin 2 (IL 2) receptor acquisition (determined with anti-Tac antibody in an immunofluorescence assay) induced by the lectin mitogen phytohemagglutinin (PHA) or by the phorbol ester 12-O-tetradecanoyl-phorbol-13 acetate (TPA). OKT11A, 9.6, and 35.1 were found to suppress [3H]thymidine incorporation and IL 2 receptor acquisition stimulated by PHA but not by TPA. This inhibition was not attributable to a lag in kinetics, but was sustained throughout 4 to 5 days of culture. Because OKT11A and 9.6 have been reported to suppress lectin mitogen-induced IL 2 production, we attempted to overcome inhibition of proliferation with exogenous IL 2 (MLA144 supernatants or immunoaffinity-purified human IL 2). Adding IL 2 at the initiation of culture abrogated the suppressive effect of all three anti-p50 antibodies on proliferation and on the acquisition of IL 2 receptors, raising the possibility that IL 2 may up-regulate expression of its cellular receptor on human T lymphocytes. These data, together with previous reports, indicate that OKT11A, 9.6, and 35.1 suppress lectin mitogen-induced T cell proliferation by impairing both IL 2 elaboration and IL 2 receptor acquisition, and suggest that IL 2 may be capable, at least under some conditions, of increasing expression of IL 2 receptors on human T lymphocytes.
ChemInform Abstract: Versatile Synthesis of 6‐Alkyl‐ and Aryl‐Substituted Pyridoxal Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Efficient microwave assisted synthesis of metal–organic framework UiO-66: optimization and scale up (2015)

A highly efficient and scalable microwave assisted synthesis of zirconium-based metal-organic framework UiO-66 was developed. In order to identify the best conditions for optimizing the process, a wide range of parameters was investigated. The efficiency of the process was evaluated with the aid of four quantitative indicators. The properties of the materials prepared by microwave irradiation were compared with those synthesized by conventional heating, and no significant effects on morphology, crystal size, or defects were found from the use of microwave assisted heating. Scale up was performed maintaining the high efficiency of the process.
Compressive sampling based MVDR spectrum sensing (2010)

We propose a compressive sampling (CS) based MVDR spectrum estimator, which estimates the wideband spectrum from the compressed signals with sub-Nyquist-rate sampling. To analyze detection performance, we derive the statistics of the estimated CS MVDR spectrum considering finite samples. We also show that different compression matrices produce different levels of signal leakage and influence the computation of detection thresholds.
Recycling of a thermoresponsive “catalyst pill”: separation of a molecular catalyst in solid ethylene carbonate in various reactions (2023)

A versatile way of recycling molecular catalysts is presented by using ethylene carbonate (EC) as a solvent in a multiphase system. EC is liquid at reaction temperature and solid at room temperature, trapping the catalyst to enable easy separation.
SAR study of different MIMO antenna designs for LTE application in smart mobile phones (2012)

This paper reports a study of specific absorption rate (SAR) for LTE MIMO antennas in mobile phones, with special consideration to the effects of different chassis lengths and different types of MIMO antennas. Two designs of dual elements MIMO antenna are studied under two typical LTE and mobile phone frequency points. The simulations are carried out both for a specific anthropomorphic mannequin (SAM) head phantom and a flat phantom. The measurements on the flat phantom are carried out as well to verify our simulation results.
Assessment of insulin action on carbohydrate metabolism: physiological and non‐physiological methods (2013)

Carbohydrate metabolism in humans is regulated by insulin secretion from pancreatic β-cells and glucose disposal by insulin-sensitive tissues. Insulin facilitates glucose utilization in peripheral tissues and suppresses hepatic glucose production. Any defects in insulin action predispose an individual to glucose intolerance and Type 2 diabetes mellitus. Early detection of defects in insulin action could provide opportunities to prevent or delay progression of the disease state. There are different approaches to assess insulin action. Initial methods, such as peripheral insulin concentration and simple indices, have several limitations. Subsequently, researchers developed methodologies using intravenous glucose infusion to determine glucose fluxes. However, these methodologies are limited by being non-physiological. Newer, innovative techniques that have been developed are more sophisticated and physiological. By modelling glucose kinetics using isotope dilution techniques, several robust parameters can be obtained that are physiologically relevant and sound. This brief review summarizes most of the non-physiological and physiological methodologies used to measure the variables of insulin action.
Identification and rejection of pile-up jets at high pseudorapidity with the ATLAS detector (2017)

The rejection of forward jets originating from additional proton-proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudorapidity range <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo>|</mml:mo> <mml:mi>η</mml:mi> <mml:mo>|</mml:mo> <mml:mo>></mml:mo> <mml:mn>2.5</mml:mn></mml:mrow> </mml:math> . This paper presents a novel strategy for forward pile-up jet tagging that exploits jet shapes and topological jet correlations in pile-up interactions. Measurements of the per-jet tagging efficiency are presented using a data set of 3.2 fb <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow></mml:mrow> <mml:mrow><mml:mo>-</mml:mo> <mml:mn>1</mml:mn></mml:mrow> </mml:msup> </mml:math> of proton-proton collisions at a centre-of-mass energy of 13 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mspace></mml:mspace> <mml:mtext>TeV</mml:mtext></mml:mrow> </mml:math> collected with the ATLAS detector. The fraction of pile-up jets rejected in the range <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>2.5</mml:mn> <mml:mo><</mml:mo> <mml:mo>|</mml:mo> <mml:mi>η</mml:mi> <mml:mo>|</mml:mo> <mml:mo><</mml:mo> <mml:mn>4.5</mml:mn></mml:mrow> </mml:math> is estimated in simulated events with an average of 22 interactions per bunch-crossing. It increases with jet transverse momentum and, for jets with transverse momentum between 20 and 50 GeV, it ranges between 49% and 67% with an efficiency of 85% for selecting hard-scatter jets. A case study is performed in Higgs boson production via the vector-boson fusion process, showing that these techniques mitigate the background growth due to additional proton-proton interactions, thus enhancing the reach for such signatures.
A Rigorous Study of Package and PCB Effects on W-CDMA Upconverter RFICs (2006)

A Volterra-series analysis is presented to study the package and printed circuit board (PCB) effects on the linearity of two wideband code-division multiple-access upconverter RF integrated circuit (RFIC) designs. The first design adopts a recently popular micromixer with a class AB input stage. The second design is based on a commonly used Gilbert mixer with emitter degeneration. Both upconverter RFICs are designed to have the same adjacent channel power ratio (ACPR) in the chip-level simulation. After fabrication, packaging, and testing on the PCB, the micromixer-based design consumes less direct current, but causes more degradation in the ACPR performance due to the influence of package and PCB when compared to the Gilbert mixer-based design. The theoretical analysis indicates that the micromixer-based upconverter RFIC is rather susceptible to the parasitic effects from the ground interconnect and, therefore, it needs a better package solution with a lower ground inductance for practical use. Comparison between theory and measurement shows good agreement in predicting the variations of conversion gain and ACPR due to the presence of the package and PCB
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma (2005)

Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular pattern that resembles human alcoholic and nonalcoholic fatty liver disease. Fibrosis in PDGF-C transgenic mice, as demonstrated by staining and hydroxyproline content, is preceded by activation and proliferation of hepatic stellate cells, as shown by collagen, alpha-smooth muscle actin and glial fibrillary acidic protein staining and between 8 and 12 months of age is followed by the development of liver adenomas and hepatocellular carcinomas. The hepatic expression of a number of known profibrotic genes, including type beta1 TGF, PDGF receptors alpha and beta, and tissue inhibitors of matrix metalloproteinases-1 and -2, increased by 4 weeks of age. Increased PDGF receptor alpha and beta protein levels were associated with activation of extracellular regulated kinase-1 and -2 and protein kinase B. At 9 months of age, PDGF-C transgenic mice had enlarged livers associated with increased fibrosis, steatosis, cell dysplasia, and hepatocellular carcinomas. These studies indicate that hepatic expression of PDGF-C induces a number of profibrotic pathways, suggesting that this growth factor may act as an initiator of fibrosis. Moreover, PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis.
cis‐ and trans‐Stereoselective Epoxidation of N‐Protected 2‐Cyclohexen‐1‐ylamines. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Risk factors for 30‐day complications after cancer surgery in geriatric patients: a secondary analysis (2018)

Nutritional and physical performance risk factors that predicted the severity of complications differed between major and higher-grade post-operative complications, but hypoalbuminaemia independently predicted both. The results support the need for pre-operative risk screening. Due to the explorative nature of the study, further research is required in larger cohorts to corroborate these findings.
Superplastic Deformation of Nano-Sized α-Sialon Ceramics (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Fiber Based Frequency Comb Lasers (2005)

The carrier envelope offset phase of a polarization-maintaining fiber frequency comb laser is stabilized for long periods of time. The performance of the system in metrology applications is comparable to a traditional Ti: sapphire-based comb but surpasses in terms of stability, ruggedness, compactness and ease of use.
Soluble Precursors for CuInSe2, CuIn1–xGaxSe2, and Cu2ZnSn(S,Se)4 Based on Colloidal Nanocrystals and Molecular Metal Chalcogenide Surface Ligands (2012)

We report a new platform for design of soluble precursors for CuInSe(2) (CIS), Cu(In(1-x)Ga(x))Se(2) (CIGS), and Cu(2)ZnSn(S,Se)(4) (CZTS) phases for thin-film potovoltaics. To form these complex phases, we used colloidal nanocrystals (NCs) with metal chalcogenide complexes (MCCs) as surface ligands. The MCC ligands both provided colloidal stability and represented essential components of target phase. To obtain soluble precursors for CuInSe(2), we used Cu(2-x)Se NCs capped with In(2)Se(4)(2-) MCC surface ligands or CuInSe(2) NCs capped with {In(2)Cu(2)Se(4)S(3)}(3-) MCCs. A mixture of Cu(2-x)Se and ZnS NCs, both capped with Sn(2)S(6)(4-) or Sn(2)Se(6)(4-) ligands was used for solution deposition of CZTS films. Upon thermal annealing, the inorganic ligands reacted with NC cores forming well-crystallized pure ternary and quaternary phases. Solution-processed CIS and CZTS films featured large grain size and high phase purity, confirming the prospects of this approach for practical applications.
Tuning the optical emission of MoS2 nanosheets using proximal photoswitchable azobenzene molecules (2014)

We report photoluminescence measurements performed on monolayer- and two-layer-MoS2 placed on two types of mixed self-assembled monolayers (mSAMs) of photoswitchable azobenzene molecules. The two mSAMs differ via the electronegative character of the azobenzene derivatives. Thin layers of a transition metal dichalcogenide—MoS2—were mechanically exfoliated on mSAM to allow for direct interaction between the molecules and the MoS2 layers. When the MoS2 nanosheet is in contact with the electropositive azobenzene molecules in trans configuration, an emission side band at lower energies and at low excitation powers suggest n-type doping. The photoisomerization of the molecules from trans to cis configuration lowers the doping, quenching the side band and enhancing the overall PL efficiency by a factor of ∼3. Opposite results were observed with the chlorinated, more electronegative molecules, exhibiting a reversed trend in the PL efficiency between trans and cis, but with an overall larger intensity. The type of doping induced by the two types of mSAMs was determined by Kelvin probe force microscopy technique.
Defective Lung Macrophages in Pulmonary Alveolar Proteinosis (1976)

Lung macrophages obtained by segmental lavage from three patients with pulmonary alveolar proteinosis were studied in vitro. The macrophages exhibited morphologic abnormalities including excessive lipid accumulation and giant secondary lysosome formation. These cells survived poorly in tissue culture, showed impaired chemotactic activity, and had decreased adhesiveness to glass. They phagocytized normally but had substantially decreased capacity to kill ingested Candida pseudotropicalis. Evidence was obtained that the macrophage defect was acquired and probably related to ingestion of the proteinaceous alveolar fluid. Peripheral blood monocyte function was normal in one patient and morphologic abnormalities were produced in normal monocyte-derived macrophages cultured with proteinaceous lavage material. These studies suggest that the lung macrophage in alveolar proteinosis is a defective cell as a consequence of an abnormal pulmonary environment.
Clinico-pathological predictors of clinical complete response in rectal cancer (2022)

We identified routine clinic-pathological, inflammatory and radiotherapy-related variables which are independently associated with cCR. A nomogram was developed to predict cCR. The performance characteristics from this model were on the prior clinical utility threshold. Additional research is required to develop more associated variables to better select patients with rectal cancer undergoing chemoradiotherapy who may benefit from pursuing a W&W strategy.
Improved Organ Sparing Using Auto-Planned Stanford Volumetric Modulated Arc Therapy for Total Body Irradiation (VMAT-TBI) Technique (2023)

Purpose/Objectives: To evaluate dosimetric differences between auto-planned Volumetric Modulated Arc Therapy (VMAT) Total Body Irradiation (TBI) technique and 2D AP/PA TBI technique. Methods: Ten pediatric patients treated with VMAT-TBI on Varian c-arm linac were included in this study. VMAT-TBI plans were generated using our in-house developed and publicly shared auto-planning scripts. For each VMAT-TBI plan, a 2D AP/PA plan was created replicating the institution’s clinical setup with the patient positioned at extended SSD with a compensator to account for differences in patient thickness, 50%-transmission daily lung blocks and electron chest-wall boosts prescribed to 50% of the photon prescription. Clinically relevant metrics were analyzed and compared between the VMAT and 2D plans. Results: All VMAT-TBI plans achieved PTV D90%≥100% of prescription. VMAT-TBI PTV D90% significantly increased (6.2%±2.4%, p&lt;0.001) compared to the 2D technique, whereas no differences were observed in global Dmax (p&lt;0.2) and PTV V110% (p&lt;0.4). Compared to the 2D plans, significant decreases in the Dmean to the lungs (-25.6%±11.5%, p&lt;0.001) and lungs-1cm (-34.1%±10.1%, p&lt;0.001) were observed with the VMAT plans. The VMAT technique also provided additional sparing to other organs: for 12Gy prescription, kidneys Dmean of 64.7%±3.3%; for 2Gy prescription, testes/ovaries (Dmean of 31.6%±10.7%), brain (Dmean of 74.8%±1.6%) and thyroid (Dmean of 72.5±3.5%). Conclusions : Superior lung sparing with improved target coverage and similar global Dmax were observed with the VMAT plans as compared to 2D plans. In addition, VMAT-TBI plans provided greater dose reductions in gonads, kidneys, brain, and thyroid.
2D Label Free Microscopy Imaging Analysis Using Machine Learning (2020)

Separation and isolation of living cells plays an important role in the fields of medicine and biology with label-free imaging often used for isolating cells. The analysis of label-free cell images has many challenges when examining the behavior of cells. This paper presents methods to analyze label-free cells. Many of the tools we describe are based on machine learning approaches. We also investigate ways of augmenting limited availability of training data. Our results demonstrate that our proposed methods are capable of successfully segmenting and classifying label-free cells.