gebhart/patrepeval huggingface dataset:
PS 07-29 FLAVONE DERIVATIVE, CSH-3-124 DECREASES ARTERIAL BLOOD PRESSURE THROUGH INHIBITION OF ANGIOTENSIN II (2016)

Objective: Flavones are polyphenolic compounds that are included in the human diet such as vegetables and nuts. A number of studies have suggested that higher flavonoid intake is associated with lower cardiovascular mortality. This study was designed to investigate the inhibitory effects of a novel flavonoid derivative, CSH-3-124; (E)-2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-7-yl 3-(pyridine-3-yl)acylate, on angiotensin II(Ang II) and to examine the vasodilator effects of it. Design and Method: To investigate the effects of flavone derivative, CSH-3-124 on Ang II, the vascular smooth muscle cells(VSMCs) proliferation and migration assay was done. Primary cultured VSMCs from male Sprague-Dawley rat aorta were stimulated by Ang II and examined with or without CSH-3-124. To evaluate the vasodilator effects, the isometric tension of rat thoracic aorta was recorded by using multi-wire myograph systems with or without CSH-3-124. In vivo, blood pressure(BP) was measured with or without intraperitoneal injection of CSH-3-124 after Ang II infusion with mini-osmotic pump in C57B6 mice. Results: The proliferation and migration of VSMCs by Ang II was inhibited significantly when added Ang II and CSH-3-124 together compared to Ang II only (control; 1.00 ± 0.03/1.00 ± 0.18 folds vs. Ang II; 1.71 ± 0.14/0.37 ± 0.07 folds vs. Ang II and CSH-3-124; 0.87 ± 0.05/0.83 ± 0.09 folds as relative cell counting for proliferation/relative wound area for migration, p < 0.05). The CSH-3-124 showed a dose dependent vasorelaxation (96.5% for 10−6 M, 72.1% for 10−5 M, 37.8% for 10−4 M as percent of vasocontracting effect of phenylephrine 10−7 M). The Ang II-induced hypertension in mice was decreased after CSH-3-124 treatment (0.75 ± 22.69 for control vs. −66.53 ± 4.44 and −67.88 ± 2.68 mmHg for CSH-3-124 10−4M and 10−5 M as a change of BP after 3 hours, p < 0.05). Conclusions: In conclusion, a flavone derivative, CSH-3-124 inhibited the VSMCs proliferation and migration, and decreased blood pressure through suppression of Ang II. We suggest that CSH-3-124 can be a useful treatment for cardiovascular disease including hypertension.
Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of Drug (2000)

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) is a major obstacle to the full success of combined antiretroviral therapy. High-level resistance to these compounds is the consequence of stepwise accumulation of amino acid substitutions in the HIV-1 protease (PR), following pathways that usually differ from one inhibitor to another. The selective advantage conferred by resistance mutations may depend upon several parameters: the impact of the mutation on virus infectivity in the presence or absence of drug, the nature of the drug, and its local concentration. Because drug concentrations in vivo are subject to extensive variation over time and display a markedly uneven tissue distribution, the parameters of selection for HIV-1 resistance to PI in treated patients are complex and poorly understood. In this study, we have reconstructed a large series of HIV-1 mutants that carry single or combined mutations in the PR, retracing the accumulation pathways observed in ritonavir-, indinavir-, and saquinavir-treated patients. We have then measured the phenotypic resistance and the drug-free infectivity of these mutant viruses. A deeper insight into the evolutionary value of HIV-1 PR mutants came from a novel assay system designed to measure the replicative advantage of mutant viruses as a function of drug concentration. By tracing the resultant fitness profiles, we determined the range of drug concentrations for which mutant viruses displayed a replicative advantage over the wild type and the extent of this advantage. Fitness profiles were fully consistent with the order of accumulation of resistance mutations observed in treated patients and further emphasise the key importance of local drug concentration in the patterns of selection of drug-resistant HIV-1 mutants.
Re: Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy (2010)

No AccessJournal of UrologyInvestigative Urology1 Feb 2011Re: Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.10.008AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy." The Journal of Urology, 185(2), p. 751 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 2February 2011Page: 751 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Preservation of Functional Virus-Specific Memory CD8+ T Lymphocytes in Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys (2006)

Functional impairment of virus-specific memory CD8(+) T lymphocytes has been associated with clinical disease progression following HIV, SIV, and simian human immunodeficiency virus infection. These lymphocytes have a reduced capacity to produce antiviral cytokines and mediators involved in the lysis of virally infected cells. In the present study, we used polychromatic flow cytometry to assess the frequency and functional capacity of central memory (CD28(+)CD95(+)) and effector memory (CD28(-)CD95(+)) subpopulations of Gag-specific CD8(+) T cells in SIV/simian human immunodeficiency virus-infected rhesus monkeys. The aim of this study was to determine whether Ag-specific, memory CD8(+) T cell function could be preserved in infected monkeys that had been immunized before infection with a vaccine regimen consisting of a plasmid DNA prime followed by a recombinant viral vector boost. We observed that vaccination was associated with the preservation of Gag-specific central memory CD8(+) T cells that were functionally capable of producing IFN-gamma, and effector memory CD8(+) T cells that were capable of producing granzyme B following viral Ag exposure.
A Novel Approach for Radar-Based Human Activity Detection and Classification (2021)

In this paper, we propose a novel approach for real-time radar-based human activities detection and classification. In this approach, first, the radar transceiver is mounted on the room's ceiling leading to considerable variations of the relative received power as the subject perform the different activities. Second, to exploit the different activities' dynamics (i.e. evolution in the time domain), radar data is registered over a long period (around 8 seconds) leading to distinctive signatures corresponding to the different activities. Then Machine Learning (ML) techniques are used for these activities' classification. The obtained results demonstrate that this approach performs well both in millimeter Wave (mmWave) and in the sub-6GHz bands. We even obtained better results in the sub-6GHz band with an average classification accuracy of 95.7% compared to 89.8% obtained in the mmWave band.
Project Wise (Integrated Wireless Sensing) (2006)

Specific Targeted Research Project WISE concerns development of new technologies for wireless sensing in aircraft environment. Current aircraft monitoring systems use sensors hard wired to their electronic acquisition unit. •It precludes acquisition of major parameters where wires cannot be installed. •It results in complex installation. •It very often results in increasing weight. The project "Objectives" are to: •enhance aircraft system monitoring by developing concepts based on new wireless technologies and integrated sensing solutions: ⋄with autonomous sensor powering and low consumption ⋄compatible with the harsh environment of aircraft systems •allow the monitoring of parameters that are not available or hardly available by physical link such as wiring or fluid connection •replace or simplify wiring solutions •continue monitoring or improve redundancy when with the current solutions the link would be stopped (wire cut, fluid line damaged or destroyed) (e.g.: fire event, engine rotor burst event). Consequently, wireless networks and wired networks could then be mixed to achieve essential or critical safety levels. •Improve information segregation: wireless technologies allow saving wiring routing space which shall be taken to improve the segregation of other wired power or signal information lines.
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease (2008)

The data indicate that the right hemisphere rhinal pattern is over represented in AD as compared with control. However, in normal subjects the EC rhinal pattern is not associated with a diminished EC tissue size. It remains to be demonstrated if the right EC rhinal sulcus pattern association with AD reflects genetic or developmental influences.
Endothelial expression of selectins during endotoxin preconditioning (2000)

Although bacterial endotoxins [lipopolysaccharide (LPS)] can confer tissue resistance to subsequent inflammatory insults, the mechanisms that underlie this LPS-preconditioning (LPS-PC) response remain poorly defined. The dual-radiolabeled monoclonal antibody technique was used to examine whether LPS-PC alters the upregulation (protein) of E- and P-selectins after subsequent LPS challenge. In the gut of wild-type (C57BL/6J) mice, LPS-PC was associated with a reduction in E- (66%) and P-selectin (33%) expression. A similar reduction in E-selectin expression was observed in mutant mice that were genetically deficient in either the endothelial or inducible isoform of nitric oxide synthase or that overexpressed the human gene for Cu/Zn superoxide dismutase. Severe combined immunodeficient mice, genetically devoid of lymphocytes, did exhibit partial inhibition of the LPS-PC response. We conclude that 1) LPS-PC can be demonstrated for E- and P-selectins in some vascular beds (e.g., gut), 2) the mechanism(s) underlying this blunted selectin response does not include a major role for either nitric oxide and superoxide, and 3) circulating lymphocytes may contribute to the LPS-PC response.
Optimal Spatiotemporal Focusing Through Complex Scattering Media (2012)

We demonstrate, based on spatial and frequency resolved wave front shaping of ultrasound with a nonlinear feedback signal, how to achieve optimal spatiotemporal focusing through a complex scattering medium.
Dendrimer Generation Effects on Photodynamic Efficacy of Dendrimer Porphyrins and Dendrimer-Loaded Supramolecular Nanocarriers (2007)

A series of poly(benzyl ether) dendrimer porphyrins (DPs) (Gn = n-generation dendrimer, n = 1−3) was examined as potential photosensitizers for photodynamic therapy (PDT). Polyion complexes (PICs) between the DPs and poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) were formed via an electrostatic interaction between the positively charged poly(l-lysine) (PLL) segment and negatively charged periphery of the DPs. Dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) showed that G3 formed a core−shell-type nanocarrier micelle, whereas G1 and G2 formed irregular-shaped nanoparticles with a relatively high polydispersity. The photophysical properties of the DP-loaded PIC nanocarriers strongly depend on the generation of the DPs. In the case of G1 and G2, their fluorescence lifetime and oxygen consumption ability were significantly reduced by the formation of the PIC nanocarriers, whereas the G3-loaded PIC nanocarrier exhibited almost comparable fluorescence lifetimes and oxygen consumption abilities to the free G3. The incorporation of DPs into PIC nanocarriers resulted in an appreciable increase in the cellular uptake, yet inversely correlated with the generation. Alternatively, the photocytotoxicity of the DPs within the nanocarriers increased with an increase in the generation despite a decrease in the cellular uptake. By correlating the effects of the uptake amount with the photocytotoxicity, the PIC nanocarriers showed remarkable enhancement of the PDT efficacy dependent on the generation of DPs.
Compliant actuator designs (2009)

In the growing fields of wearable robotics, rehabilitation robotics, prosthetics, and walking k robots, variable stiffness actuators (VSAs) or adjustable compliant actuators are being designed and implemented because of their ability to minimize large forces due to shocks, to safely interact with the user, and their ability to store and release energy in passive elastic elements. This review article describes the state of the art in the design of actuators with adaptable passive compliance. This new type of actuator is not preferred for classical position-controlled applications such as pick and place operations but is preferred in novel robots where safe human- robot interaction is required or in applications where energy efficiency must be increased by adapting the actuator's resonance frequency. The working principles of the different existing designs are explained and compared. The designs are divided into four groups: equilibrium-controlled stiffness, antagonistic-controlled stiffness, structure-controlled stiffness (SCS), and mechanically controlled stiffness.
Articels : Multidrug Resistance Reversal Activity of Methanol Extracts from Basidiomycete Mushrooms in Cancer Cells (2012)

Mushrooms have a long history of use in traditional medicine, and hundreds of novel constituents in mushrooms with miraculous biological properties have been identified recently. Although diverse effects for medicinal use of mushrooms such as anticancer activity are proven, their reversal activities of drug resistance in cancer cells was rarely reported so far. In the search for novel medicinal use of mushrooms, we tested the multidrug resistance (MDR) reversal activities of diverse mushrooms collected from Korea. Among, the mushroom extracts tested, Cantharellus cibarius (M02) and Russula emetica (M12) revealed MDR reversal activities of paclitaxel in the P-glycoprotein (Pgp)-positive HCT15 and MES-SA/dX5 cancer cells, but not in the Pgp-negative A549 and MES-SA cancer cells. In addition, these mushrooms also enhanced the cytotoxicity of doxorubicin, another well-kwown Pgp-associated anticancer drug against MES-SA/DX5 cells, but not against MES-SA cells. Meanwhile, the cytotoxicity of cisplatin, a well-known Pgp-non-associated anticancer drug, was not affected by the mushrooms all the cells tested. From these results, we suspected that some ingredients of M02 and M12 have Pgp-associated MDR reversal activities.
Iris authentication in handheld devices - considerations for constraint-free acquisition (2015)

As a near ideal biometric, iris authentication is widely used and mobile acquisition techniques are known. But iris acquisition on handheld imaging devices, such as smartphones, poses multiple, unique challenges. In this paper, a range of factors that affect the quality of iris images are reviewed. Iris size, image quality and acquisition wavelength are found to be key factors. Experimental results are presented confirming the lower limits of iris size for useful authentication performance. The authentication workflow for handheld devices is described. A case study on a current smartphone model is presented, including calculation of the pixel resolution that can be achieved with a visible-only optical system. Based on these analyses, system requirements for unconstrained acquisition in smartphones are discussed. Several design strategies are presented and key research challenges are outlined together with potential solutions.
Dynamic accessibility (2011)

Human abilities and situations are idiosyncratic and may change frequently. Static one-size-fits-many accessibility solutions miss the opportunities that arise from careful consideration of an individual's abilities and fail to address the sometimes dynamic aspect of those abilities, such as when a user's activity or context causes a "situational impairment." The goal of this workshop is to bring together researchers and practitioners in accessibility, mobile HCI, and interactive intelligent systems who are pursuing agile, data-driven approaches that enable interactive systems to adapt or become adapted to the needs and abilities of a particular individual in a particular context.
Recognition by xenogeneic cytotoxic T lymphocytes of cells expressing HLA-A2 or HLA-B7 after DNA-mediated gene transfer. (1983)

Murine L cells expressing HLA-A2 or -B7 antigens were isolated after cotransformation of thymidine kinase-negative cells with the herpes simplex virus thymidine kinase gene and the genomic clones containing either the HLA-A2 or -B7 genes. Monoclonal antibody binding analyses demonstrated the stable cell surface expression of HLA antigens by these cells at levels of up to 40% of the amount expressed by the human B lymphoblastoid cell line, JY. The HLA-A2 and -B7 antigens expressed by the L cells retained all of the antibody-defined, heavy-chain-associated antigenic determinants but lacked those determinants associated with human beta 2-microglobulin. These HLA transformants were capable of functioning as targets for monoclonal cytotoxic T lymphocytes (CTL) that specifically recognize the HLA-B7 or -A2 antigens expressed by JY cells. However, the efficiency of lysis, relative to the JY cell line, was 50-99% for individual CTL. In addition, not all of these CTL were capable of lysing the appropriate transformants. Because the antigens appear by serological criteria to be structurally intact and expressed at high levels, these results suggest that the complementation of the HLA heavy chains with mouse, rather than human, beta 2-microglobulin may alter the antigenic determinants that are important for CTL recognition.
How to Teach and How to Learn Kinematics of Machinery (2018)

Study of mechanism or kinematics of machinery is one of the most important fields of mechanical engineering. There are so many good textbooks on kinematics of machinery. On the other hand, it is often said that kinematics of machinery is difficult. In this paper, a trial in the author’s lecture is introduced.
Front Matter: Volume 9858 (2016)

This PDF file contains the front matter associated with SPIE Proceedings Volume 9858, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing.
Leveraging Deep Neural Networks and Knowledge Graphs for Entity Disambiguation (2015)

Entity Disambiguation aims to link mentions of ambiguous entities to a knowledge base (e.g., Wikipedia). Modeling topical coherence is crucial for this task based on the assumption that information from the same semantic context tends to belong to the same topic. This paper presents a novel deep semantic relatedness model (DSRM) based on deep neural networks (DNN) and semantic knowledge graphs (KGs) to measure entity semantic relatedness for topical coherence modeling. The DSRM is directly trained on large-scale KGs and it maps heterogeneous types of knowledge of an entity from KGs to numerical feature vectors in a latent space such that the distance between two semantically-related entities is minimized. Compared with the state-of-the-art relatedness approach proposed by (Milne and Witten, 2008a), the DSRM obtains 19.4% and 24.5% reductions in entity disambiguation errors on two publicly available datasets respectively.
Agenda influence and its implications (1977)

When choosing from many competing alternatives, groups
often narrow the range of and then select from the
remaining alternatives using a predetermined procedure or
agenda. In some groups, this process may involve the use of committee reports and parliamentary procedure. In others, choices may be narrowed by common consent, by the chairman, or by some other means and voting may proceed in a predetermined, non-parliamentary fashion. Recent developments in the theory of group (embodied in a literature that has come to be known as the social choice literature) suggest that there probably is no single
nondictatorial method of aggregating the preferences of an electorate that will reliably produce a which satisfies minimal consistency and rationality standards.
Recombinant Toxins That Bind to the Urokinase Receptor Are Cytotoxic without Requiring Binding to the α2-Macroglobulin Receptor (2000)

The alpha(2-)macroglobulin receptor (alpha(2)MR) has been reported to mediate the internalization of the urokinase plasminogen activator receptor (uPAR) via ligand binding to both receptors. To target malignant uPAR-expressing cells and to determine whether uPAR can internalize without ligand binding to alpha(2)MR, we engineered two recombinant toxins, ATF-PE38 and ATF-PE38KDEL. Each consists of the amino-terminal fragment (ATF) of human urokinase and a truncated form of Pseudomonas exotoxin (PE) devoid of domain Ia, which binds alpha(2)MR. ATF-PE38 and ATF-PE38KDEL were cytotoxic toward malignant uPAR-bearing cells, with IC(50) values as low as 0.02 ng/ml (0.3 pM). Cytotoxicity could be blocked using either recombinant urokinase or free ATF, indicating that the cytotoxicity of the recombinant toxins was specific. Radiolabeled ATF-PE38 had high affinity for uPAR (K(d) = 0.4-8 nM) on a variety of different malignant cell types and internalized at a rate similar to that of ATF. The cytotoxicity was not diminished by receptor-associated protein, which binds and shields the alpha(2)MR from other proteins, or by incubation with phorbol myristate acetate, which is known to decrease the number of alpha(2)MRs in U937 cells or by antibodies to alpha(2)MR. Therefore, these recombinant toxins appear to internalize via uPAR without association with the alpha(2)MR.
Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice (2018)

Long-acting glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists (GLP-1RA), such as exendin-4 (Ex4), promote weight loss. On the basis of a newly discovered interaction between GLP-1 and oleoylethanolamide (OEA), we tested whether OEA enhances GLP-1RA-mediated anorectic signaling and weight loss. We analyzed the effect of GLP-1+OEA and Ex4+OEA on canonical GLP-1R signaling and other proteins/pathways that contribute to the hypophagic action of GLP-1RA (AMPK, Akt, mTOR, and glycolysis). We demonstrate that OEA enhances canonical GLP-1R signaling when combined with GLP-1 but not with Ex4. GLP-1 and Ex4 promote phosphorylation of mTOR pathway components, but OEA does not enhance this effect. OEA synergistically enhanced GLP-1- and Ex4-stimulated glycolysis but did not augment the hypophagic action of GLP-1 or Ex4 in lean or diet-induced obese (DIO) mice. However, the combination of Ex4+OEA promoted greater weight loss in DIO mice than Ex4 or OEA alone during a 7-day treatment. This was due in part to transient hypophagia and increased energy expenditure, phenotypes also observed in Ex4-treated DIO mice. Thus, OEA augments specific GLP-1RA-stimulated signaling but appears to work in parallel with Ex4 to promote weight loss in DIO mice. Elucidating cooperative mechanisms underlying Ex4+OEA-mediated weight loss could, therefore, be leveraged toward more effective obesity therapies.
ChemInform Abstract: Synthesis of α,α‐Disubstituted α‐Amino Acid Amides by Phase‐Transfer Catalyzed Alkylation. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.