gebhart/patrepeval huggingface dataset:
Abstract 1049: PIM2 inhibitor as a targeted therapy for the treatment of multiple myeloma patients with specific genetic signatures. (2013)

Abstract Jasco Pharmaceuticals has developed a novel and selective pan-PIM inhibitor (JP_11646) that has demonstrated biochemical IC50s of 24, 0.5 and 1 nM for PIM1, PIM2 and PIM3 respectively. Jasco also developed an engineered cell line to measure PIM2 transphosphorylation by over-expressing human PIM2 in human HEK293 cells together with human BAD as the substrate. The cell based assay measures the phosphorylation levels of BAD at Ser112 attributed solely to PIM2. JP_11646 exhibited a 590 nM IC50 in this cell based PIM2 assay confirming the MOA. JP_11646 increases apoptosis and decreases cell viability in multiple myeloma cell lines with the t(14;16) and t(4;14) translocations, which are known markers for poor prognosis. JP_11646 is orally bioavailable and has demonstrated in vivo efficacy, inhibiting tumor growth by &amp;gt;80% in a MM1.S tumor xenograft study. These data provide solid rationale for further development of JP_11646 as a targeted therapy for specific population of multiple myeloma patients that exhibit these genetic markers. Citation Format: Carmen M. Baldino, Justin Caserta, Stephane Dumas, Yvonne Flanders, Jayakumar Nair, Kelvin P. Lee. PIM2 inhibitor as a targeted therapy for the treatment of multiple myeloma patients with specific genetic signatures. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1049. doi:10.1158/1538-7445.AM2013-1049
PINCER FEMOROACETABULAR IMPINGEMENT AND RETROVERSION: A 3D STUDY (2011)

Pincer femoroacetabular impingement (FAI) is cited as being the result of a socket that is either too deep or retroverted, or both. Using 3D-CT analysis, we set out to quantify the acetabular rim shape and orientation to determine the roles of these two factors in FAI. Twenty pincer acetabulae were selected from patients undergoing image based navigated surgery, where the lateral centre edge angle was greater than 40° on plain radiographs. The normal group of disease free sockets were obtained from a CT colonography database.
Colorimetric detection of epinephrine using an optimized paper-based aptasensor (2017)

Morphological modification of gold nanoparticles to obtain a highly efficient paper based sensor for colorimetric detection of epinephrine (LOD – Limit of Detection).
Biogenesis of Asparagine-Linked Glycoproteins Across Domains of Life—Similarities and Differences (2018)

ADVERTISEMENT RETURN TO ISSUEIn FocusNEXTBiogenesis of Asparagine-Linked Glycoproteins Across Domains of Life—Similarities and DifferencesJerry Eichler*Jerry EichlerDepartment of Life Sciences, Ben Gurion University of the Negev, Beersheva, Israel*E-mail: [email protected]More by Jerry Eichlerhttp://orcid.org/0000-0001-9409-8026 and Barbara ImperialiBarbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United StatesMore by Barbara Imperialihttp://orcid.org/0000-0002-5749-7869Cite this: ACS Chem. Biol. 2018, 13, 4, 833–837Publication Date (Web):February 26, 2018Publication History Published online26 February 2018Published inissue 20 April 2018https://doi.org/10.1021/acschembio.8b00163Copyright © 2018 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views790Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (3 MB) Get e-AlertsSUBJECTS:Bacteria,Carbohydrates,Chemical biology,Membranes,Peptides and proteins Get e-Alerts
Spring Stiffness Selection Criteria for Nozzle Check Valves Employed in Compressor Stations (2011)

Nozzle type check valves are often employed in compressor stations in three locations: compressor outlet, station discharge, and station bypass. The fundamental design concept of these valves is based on creating a converging diverging flow through the valve internal geometry such that a minimum area is achieved at a location corresponding to the back of the check valve disk at the fully open position. This will ensure maximum hydrodynamic force coefficient which allows the valve to be fully open with minimum flow. Spring forces and stiffness determine the performance of this type of check valves and impact the overall operation and integrity of the compressor station. This paper examines the effects of various spring characteristics and stiffness in relation to the compressor and station flow characteristics. The results show that when the spring forces are higher than the maximum hydrodynamic force at minimum flow, the disk will not be at the fully open position, which will give rise to disk fluttering and potential for cyclic high velocity impact between components of the internal valve assembly. This could lead to self destruction of the check valve and subsequent risk of damage to the compressor unit itself. The paper also points to the fact that the spring selection criteria for a unit check valve are different than that for station and bypass check valves. An example of a case study with actual field data from a high pressure ratio compressor station employing this type of check valves is presented to illustrate the associated dynamic phenomena and fluid-structure interaction within the internal assembly of the check valve.
Integrating Objects into Monocular SLAM: Line Based Category Specific\n Models (2019)

We propose a novel Line based parameterization for category specific CAD\nmodels. The proposed parameterization associates 3D category-specific CAD model\nand object under consideration using a dictionary based RANSAC method that uses\nobject Viewpoints as prior and edges detected in the respective intensity image\nof the scene. The association problem is posed as a classical Geometry problem\nrather than being dataset driven, thus saving the time and labour that one\ninvests in annotating dataset to train Keypoint Network for different category\nobjects. Besides eliminating the need of dataset preparation, the approach also\nspeeds up the entire process as this method processes the image only once for\nall objects, thus eliminating the need of invoking the network for every object\nin an image across all images. A 3D-2D edge association module followed by a\nresection algorithm for lines is used to recover object poses. The formulation\noptimizes for shape and pose of the object, thus aiding in recovering object 3D\nstructure more accurately. Finally, a Factor Graph formulation is used to\ncombine object poses with camera odometry to formulate a SLAM problem.\n
STUDIES OF UNBOUND AMINO ACID DISTRIBUTIONS IN PLASMA, ERYTHROCYTES, LEUKOCYTES AND URINE OF NORMAL HUMAN SUBJECTS (1960)

After autoclaving, the latter resin sheds a small amount of a ninhydrin-positive substance with an Rf value between valine and a-amino-n-
Effects of elastic scattering on high-performance step-taper active-region quantum cascade lasers (2019)

Step-taper active-region (STA) quantum cascade lasers (QCLs) allow for both carrier-leakage suppression and ultrafast, miniband-like carrier extraction. In turn, that has led to very high internal-efficiency <i>n</i><sub>i</sub> values: ~ 77 % and 80-86 % from ~ 5.0 &mu;m- and 8-9 &mu;m-emitting QCLs, respectively. Based on extracted parameters that characterize the interfaceroughness (IFR) scattering, a study has been performed of the effects of elastic scattering, both IFR and alloy-disorder (AD) scattering, on 5.0 μm-emitting STA-QCLs. We find that the laser-transition efficiency <i>n</i><sub>tr</sub> is enhanced by ~15 % (i.e., from 83 % to ~ 95 %) due to the much stronger effect of elastic scattering on the lower-laser-level lifetime than on the effective upper-laser-level lifetime. In turn, the injection efficiency: <i>n</i><sub>inj</sub> = <i>n</i><sub>i</sub> /<i>n</i><sub>tr</sub> , reaches ~ 81 %; that is, the highest injection-efficiency value obtained to date from QCLs. Furthermore, we find that the projected upper limit for the pulsed wall-plug efficiency can reach values as high as 44.4 % for 4.6 &mu;m-emitting devices; thus, raising the possibility of CW operation of 4.5-5.0 &mu;m-emitting QCLs with wallplug-efficiency values as high as 40 %.
Парциальное окисление метана в синтез-газ на ката- лизаторах на основе ячеистых металлических носи- телей (2014)

To develop effective catalysts based on metal meshy supports for the reaction of the methane partial oxidation to synthesis gas there were the comparative tests of metal catalysts (Pd, Ni, Co, Cu, supported on a metal grid and fechral foil) obtained two ways: thermochemical and electrochemical deposition of metals. Tests were carried out in the temperature range 680–1000 °C in a flow reactor (internal diameter 10 mm) with integrated catalyst in the form of a twisted roll of wire mesh or fechral foil. It is shown that the metal supports (grid or foil) with metals (palladium, nickel) putted on them are promising for use as catalysts in the production of synthesis gas by the reaction of partial oxidation of methane in a narrow range of the molar ratio oxygen/methane (O2/СН4 = = 0,45÷0,55). In the study of catalyst surfaces by SEM there was revealed that the thermochemical deposition of VIII group metal more extensive area of active metals is formed, providing even at 900 °C almost 100 % conversion of methane with selectivity for CO over 90 %.
The Digestibility of Waste Activated Sludges (2006)

Laboratory digestion studies using waste activated sludges (WAS) were conducted to compare the digestion performance between anaerobic and aerobic processes. Nine samples of WAS from seven wastewater treatment plants were collected and batch-digested under both anaerobic and aerobic conditions for 30 days at 25 degrees C. The cation content of wastewater (both floc and solution phases) and solution biopolymer (protein and polysaccharide) was measured before and after digestion and compared with volatile solids destruction data. The study revealed that each digestion process was associated with a distinct biopolymer fraction, which accounted for differences in volatile solids reduction under anaerobic and aerobic conditions. The anaerobic digestion data showed strong correlations between soluble protein generation, ammonium production, percent volatile solids reduction, and floc iron (Fe). These data suggest that the amount of volatile solids destroyed by anaerobic digestion depends on the Fe content of floc. In aerobic digestion, polysaccharide accumulated in solution along with calcium and magnesium. For aerobic digestion, correlations between divalent cation release and the production of inorganic nitrogen were found. This implies that divalent cation-bound biopolymer, thought to be lectin-like protein, was the primary organic fraction degraded under aerobic conditions. The results of the study show that the cation content in wastewater is an important indicator of the material that will digest under anaerobic or aerobic conditions and that some of the volatile solids will digest only under either anaerobic or aerobic conditions.
Bench-Scale Reactor Tests of Low Temperature, Catalytic Gasification of Wet Industrial Wastes (1993)

Bench-scale reactor tests are under way at Pacific Northwest Laboratory to develop a low temperature, catalytic gasification system. The system, licensed under the trade name Thermochemical Environmental Energy System (TEES®), is designed for to a wide variety of feedstocks ranging from dilute organics in water to waste sludges from food processing. The current research program is focused on the use of a continuous feed, tubular reactor. The catalyst is nickel metal on an inert support. Typical results show that feedstocks such as solutions of 2 percent para-cresol or 5 percent and 10 percent lactose in water or cheese whey can be processed to &gt;99 percent reduction of chemical oxygen demand (COD) at a rate of up to 2 L/hr. The estimated residence time is less than 5 min at 360°C and 3000 psig, not including 1 to 2 min required in the preheating zone of the reactor. The liquid hourly space velocity has been varied from 1.8 to 2.9 L feedstock/L catalyst/hr depending on the feedstock. The product fuel gas contains 40 percent to 55 percent methane, 35 percent to 50 percent carbon dioxide, and 5 percent to 10 percent hydrogen with as much as 2 percent ethane, but less than 0.1 percent ethylene or carbon monoxide, and small amounts of higher hydrocarbons. The byproduct water stream carries residual organics amounting to less than 500 mg/L COD.
Brain Tumor Xenografts Using SPECT/CT (2009)

Chemokine receptor 4 (CXCR4) is expressed in a variety of cancers, including breast, brain, ovarian, and prostate. CXCR4– CXCL12 interactions are critical for tumor development, growth, and metastasis. Compared with normal tissue, neoplastic tissue (including metastases) expresses high levels of CXCR4. Previous clinical and preclinical observations suggest that CXCR4 levels could be used as a predictive marker of metastatic potential. Here we report the results of SPECT/CT of CXCR4 expression levels in experimental brain tumors using 125 I-labeled antiCXCR4 monoclonal antibodies (mAbs). Methods: hCXCR4 antibody 12G5 and control IgG2A antibody were radiolabeled. Radio-mAbs were obtained in 40%–60% yield, with 1.4–1.9 MBq/mg specific radioactivities and greater than 95% purity. Severe combined immunodeficient mice harboring U87 xenografts were used for ex vivo biodistribution and imaging studies. Surface CXCR4 expression levels on U87 tumor–derived cells were analyzed by flow cytometry. Results: Biodistribution and imaging studies showed a specific accumulation of 125I-12G5 in U87 tumors, with tumor-to-muscle uptake ratios reaching 15 6 3 at 48 h after injection. The tumor-to-tumor uptake ratio for 125 I-12G5 and 125 I-IgG2A was 2.5 at 48 h after injection. Flow cytometry analysis of tumor-derived cells showed a 2- to 7-fold increase in CXCR4 expression relative to inoculums, accounting for the high mAb uptake observed in the tumors. Conclusion: Our data demonstrate the feasibility of imaging CXCR4 expression in experimental brain tumors. The elevated CXCR4 levels observed may have been, in part, due to the hypoxic tumor mi
Towards sensitivity analysis of hybrid systems using simulink (2013)

In the design of engineered systems two types of models are used: (i) analysis models and (ii) system models. The system models are primary deliverables between design stages whereas analysis models are employed within a design stage. Sensitivity analysis studies the behavior of the system under small parameter variations which proves to be useful in design. To enable sensitivity analysis in verification of hybrid dynamic systems that model industry-size problems, support for simulation-based methods is desired. The computational semantics for simulation of corresponding analysis models must then be consistent with the computational semantics of the system models. A method is presented that enables direct sensitivity analysis on system models via an implementation in the Simulink(R) software. The approach relies on the existing ordinary differential equation solver of Simulink and the block-by-block analytic Jacobian computation to provide the analytic Jacobian for solving the sensitivity equations. Results of a prototype implementation show that sensitivity analysis can be applied to moderate size Simulink models of continuous and hybrid systems.
Implementing Multi-Agent Systems: Languages, Frameworks, and Standards (Extended Abstract)* (1998)

As multi-agent systems research nears the end of its second decade, researchers have moved beyond stand-alone, one-off systems and have begun to create the software infrastructure for quickly creating new, highly interoperable systems. However, the desire for seamless interoperability (open systems) brings with it the push to standardize on agent communication languages and related agent service facilities. Although a host of theoretical and practical controversies surround the specification of such standards, some shared, guiding principles have emerged. Many researchers focus their work on the internal structures of agents (architecture), while others focus more on the activities and structures between agents (organization). The first principle is the realization that most principles can be recast at both the intraand inter(architectural and organizational) levels. The second principle is a drive toward the reuse of models and particular behaviors both conceptually, in reusable implementations, and in the creation of generic infrastructure components. The third principle revolves around how to structure individual or multi-agent knowledge and behaviors that includes techniques for composition, layering, and abstraction. The final guiding principle is the centrality of the interoperability question. After all, what would a multiagent system be unless there are in fact multiple agents interoperating with one another?! Methodologically, research in the area of agent frameworks and languages has been pursued in both a theory-driven and application-driven manner. Often there can be significant interaction between theory and practice, as in the development of BDI-based systems (Bratman 1987; Rao & Georgeff 1995). Although there are as yet no complete solutions, multi-agent system development methodologies will be important for the software engineer-
Large-Scale Preparation of Potassium Hydroxide-Modified Silica Gel Adsorbent (1989)

Abstract A large-scale method, using custom-made apparatus, is described for making potassium hydroxide-modified silica gel. Batches as large as 2.3 kg can be made in 16 man-hours. A smaller-scale version of the method, requiring no specialized apparatus, is also described. The method can be used to integrate this adsorbent into many sampleenrichment procedures.
One- and Three-Dimensional Wall Heat Flux Calculations in a O2/H2 System (2009)

OVER the past several decades, considerable effort has been dedicated to model combustion in rocket chambers to understand and predict the conjugate heat transfer to the chamberwalls [1]. Validation of computational fluid dynamics (CFD) design tools requires, in turn, reliable experimental data assessment. This involves the need to acquire a comprehensive set of data in the same facility, including wall heat fluxes along with inflow measurements over a broad range of pressures [2]. The experimental data for CFD validation acquired to date were obtained from a range of facilities of different sizes, various internal geometry or fuel composition, and injection configurations [3–9]; therefore, wall heat fluxes were considerably different among these studies. The strength, the life cycle, and the cooling system effectiveness are highly dependent on heat transfer into and out of the system [10], and the number of studies addressing the heat transfer into the chamber walls are still inadequate. In a previous study, which was the first of its kind, Marshall et al. [11] obtained the heat flux measurements using Gordon heat flux gauges from coaxial temperature measurements that were placed along the chamber wall. The heat fluxes were, then, calculated by solving the transient axisymmetric heat flux equation. Conley et al. [12] calculated the heat fluxes from the temperature measurements at several longitudinal locations. In these studies, the heatfluxeswere calculated by solving the steady-state one-dimensional (1-D) heat conduction equation and adding a correction term to compensate the heat absorption by the chamberwalls. Thevery nature of heat transfer in the combustion chamber is, in fact, three-dimensional (3-D). Thus, calculation of heat fluxes based on a 1-D assumption may lead to errors. Vaidyanathan et al. [13] calculated wall heat fluxes by numerically solving the two-dimensional (2-D) unsteady heat conduction equation. Although more accurate when compared with 1-D assumption, the 2-D heat conduction assumption still does not take into account the longitudinal heat transfer. The current study is aimed at calculating the heat fluxes in the combustion chamber by numerically solving the 3-D heat conduction equation to assess the validity of 1-D unsteady heat conduction assumption in wall heat flux calculation. Hence, the data presented next include wall heat fluxes calculated from 3-D heat transfer assumption for a GO2=GH2 single-element shear coaxial injector at 37 bar.
An Ultrahigh Vacuum Packaging Process Demonstrating Over 2 Million Q-Factor in MEMS Vibratory Gyroscopes (2017)

Micro resonators and vibratory gyroscopes could reach their fundamental thermo-elastic damping (TED) limit in an ultravacuum condition where the viscous damping is eliminated. This article presents a reliable and repeatable high vacuum sealing process as a standalone approach for performance evaluation of dynamic micro devices. We demonstrated a micro-Torr vacuum level in a ceramic leadless chip carrier package and achieved the Q-factor over 2 million on a quad mass gyroscope, approaching the TED limit of the device by effectively eliminating the viscous damping. The long-term vacuum stability was characterized over 1 year and demonstrated that the Q-factor does not degrade over time and even continues improving. The long-term ultrahigh vacuum condition is enabled by surface desorption prior to sealing, pumping of residual gases by passive getters, and defect-free solder reflow in the sealing area. The experimental results confirmed the reliability and repeatability of the proposed sealing procedure, which can be adapted for other Micro Electro-Mechanical Systems (MEMS) with ultrahigh vacuum requirements.
Recent Approaches in the Field of Educational Psychology to ^|^ldquo;Declining Academic Standards in Japan^|^rdquo; (2003)

1999年後半から,「学力低下」が国民的関心事となった。学習指導要領の改訂と関連して, 初めのうちは「ゆとり教育推進派」対「基礎学力徹底派」の対立として議論が展開しそうになったが, 教育心理学者の働きかけもあり, 現在は比較的多面的な認識が世論の主流を占めているように見える。教育心理学の立場からは, これまで教育観に含まれる誤概念が数々指摘されており, これが日本の教育を変質させて学習の質的低下を招き, 学力が低下してきている可能性を見てとることができる。そこでは, 自己を成長させるはずの学習が単なる「労役」と化し, 学習者に意義の感じられないものとなり, 学びからの逃走が発生しているのである。教育心理学の「実践化」の動きとして, 学習の質的向上への働きかけが直接学習者になされ, 教育の質的向上を目指した試みが教員養成活動としてなされている。その他学校への働きかけまで含めると, 教育心理学の「実践化」は加速している。