gebhart/patrepeval huggingface dataset:
Palladium(II) Weak-Link Approach Complexes Bearing Hemilabile N-Heterocyclic Carbene–Thioether Ligands (2017)

A new class of homoligated palladium(II) weak-link approach (WLA) complexes bearing hemilabile N-heterocyclic carbene (NHC)-thioether ligands is reported that, unlike previous tweezer-like WLA complexes, expand and contract in a linear fashion when switching between configurational states. These complexes can be chemically switched between a trans open state and a trans closed state via the addition or subsequent extraction of Cl<sup>-</sup>. These bis(NHC) complexes also display unusual isomerization behavior. For example, an NMR spectroscopic investigation into the solution-state configuration of the open complex reveals the presence of interconverting syn,trans and anti,trans isomers, and a kinetic study shows that the barrier is large enough to isolate, store, and study the anti,trans isomer at room temperature. Notably, the linker length between the NHC and thioether moieties can be tailored with additional -CH<sub>2</sub>- groups, which affords considerable control over the geometric changes imposed by switching. Therefore, this class of complexes may be useful in the construction of allosterically regulated supramolecular assemblies and materials.
Stability of Pes1 BRCT-domain mutants and incorporation into the PeBoW-complex (2011)

<b>Copyright information:</b>Taken from "The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing"Nucleic Acids Research 2006;35(3):789-800.Published online 22 Dec 2006PMCID:PMC1807956.© 2006 The Author(s) () Stable polyclonal H1299 cells conditionally expressing wt WDR12, wt Pes1 and the indicated Pes1 BRCT-domain mutants were either left untreated or incubated with MG-132 or ALLM for 8 h. Total cell lysates were harvested and analysed by western blot analysis using the anti-HA antibody (3F10). Equal loading was verified by immunodetection for α-tubulin. () Cells were treated with 50 μg/ml cyclohexamide for the indicated time points to block protein synthesis. Western blot analysis of total cell lysates was performed using the anti-HA antibody (3F10). Immunodetection of α-tubulin is shown as loading control. () Incorporation of Pes1 BRCT-domain mutants into the PeBoW-complex. H1299 cells stably transfected with the indicated constructs were treated with doxycycline for 48 h to induce expression of the respective proteins. Cell lysates were subjected to immunoprecipitations with antibodies either directed against the HA-tag (3F10), WDR12 (1B8), Bop1 (6H11) or the isotype control (cytohesin). Equivalent amounts of total lysates used for immunoprecipitations were loaded in each lane or 20% thereof for the input. Immunodetection was performed using the anti-HA antibody. () Total cell lysates of stably transfected H1299 cells expressing HA-tagged wild-type Pes1 or the indicated mutant together with HA-tagged rodent Bop1 were separated by native gel electrophoresis. Immunodetection was perfomed using antibodies specific for the HA-tag and rodent Bop1. Denaturing gel electrophoresis and HA-tag immunodetection was performed to control expression levels.
Trigonal-bipyramidal bis(neopentylidene), neopentylidene/ethylene, and bis(ethylene) complexes of tantalum and how they react with ethylene. A catalyst for rapidly dimerizing ethylene to 1-butene (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrigonal-bipyramidal bis(neopentylidene), neopentylidene/ethylene, and bis(ethylene) complexes of tantalum and how they react with ethylene. A catalyst for rapidly dimerizing ethylene to 1-buteneJ. D. Fellmann, R. R. Schrock, and G. A. RupprechtCite this: J. Am. Chem. Soc. 1981, 103, 19, 5752–5758Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/ja00409a023https://doi.org/10.1021/ja00409a023research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Short Paper: Data Detection Techniques for OFDM Signals over Doppler-Distorted Channels (2010)

Signal scaling due to Doppler in underwater acoustic communications results in inter-carrier interference (ICI) and severely degraded detection performance in OFDM based systems in the absence of interference mitigation. Using a recently proposed partial FFT demodulation technique [5], where several FFT demodulators operate over parallel nonoverlapping segments, two efficient algorithms which reduce ICI and error probability significantly are proposed. Numerical simulations demonstrate an improvement of several dB over conventional OFDM detection techniques at the cost of a small increase in complexity. 1.
Integrated balun bandpass filter design with an optimal common mode rejection ratio (2011)

This paper describes a compact transformer-coupled balun bandpass filter design based on integrated passive device technology. Using a planar transformer with high-density fully symmetrical wiring not only greatly reduces the component size but also provides a superior balance at the differential output ports. In addition, applying the tapped feed-line structure to the balun bandpass filter is accomplished by carefully studying the impedance-matching method. Interestingly, the proposed balun bandpass filter can guarantee an optimal common-mode rejection ratio (CMRR) level in a specific operating frequency range by precisely controlling the fractional bandwidth of the filter passband.
Insights on Interactive Tabletops: A Survey of Researchers and Developers (2009)

Recently, interest in tabletop computing has surged, both within the research community and within the commercial sector. However, given the early stage of interactive tabletop adoption and current low availability, it is difficult to find end users with extended experience in using such devices. We conducted a survey of 58 tabletop researchers and developers, the only available population with longer-term tabletop use experience, to find out how they use their devices, what they use them for, and what features they consider important for novice, single-user, and collaborative scenarios. While not without inherent biases, their answers suggest important directions for further research in designing and evaluating interactive tabletop systems, including identification of obstacles to mainstream adoption, and input and ergonomic challenges.
Supplementary Figure Legend from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer (2023)

&lt;p&gt;PDF file, 44KB.&lt;/p&gt;
SNEED: Enhancing Network Security Services Using Network Coding and Joint Capacity (2010)

Traditional network security protocols depend mainly on developing cryptographic schemes and on using biometric methods. These have led to several network security protocols that are unbreakable based on difficulty of solving untractable mathematical problems such as factoring large integers. In this paper, Security of Networks Employing Encoding and Decoding (SNEED) is developed to mitigate single and multiple link attacks. Network coding and shared capacity among the working paths are used to provide data protection and data integrity against network attackers and eavesdroppers. SNEED can be incorporated into various applications in on-demand TV, satellite communications and multimedia security. Finally, It is shown that SNEED can be implemented easily where there are k edge disjoint paths between two core nodes (routers or switches) in an enterprize network.
Supplementary Figure Legend from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent (2023)

&lt;p&gt;PDF file - 45K&lt;/p&gt;
Interactive query workstation: a demonstration of the practical use of UMLS knowledge sources. (1992)

The Interactive Query Workstation (IQW) has been developed to provide clinicians with a uniform program interface for retrieving medical-related information from various computer-based information resources. These resources can vary in content (bibliographic databases, drug information, general medical text databases), function (article retrieval, differential diagnosis, drug interaction detection, or drug dosage and administration information), and media formats (local hard disk, CD-ROM, local area network, or distant telecommunication link). IQW allows modular addition of new resources as well as extension of previously installed resources. The National Library of Medicine's three Unified Medical Language System (UMLS) Knowledge Sources, the Metathesaurus (Meta), the Semantic Network, and the Information Sources Map (ISM) have been incorporated into many aspects of IQW. Meta provides information about medical terminology and aids IQW in isolating the basic concepts from a clinician's question. The Semantic Network provides information about the categorization of concepts and possible relations between concepts. It also assists IQW in determining which queries are appropriate for a set of concepts contained in the clinician's question. The ISM provides information about the content available from a computer-based resources and aids IQW in selecting an appropriate resource from which to collect information. The computer-based resource selection is performed without user intervention. This interactive demonstration shows an environment which increases the accessibility of medical information to clinicians by utilizing the three UMLS Knowledge Sources.
Prostate-specific Membrane Antigen Reporting and Data System Version 2.0 (2023)

Prostate-specific Membrane Antigen Reporting and Data System (PSMA-RADS) was introduced for standardized reporting, and PSMA-RADS version 1.0 allows classification of lesions based on their likelihood of representing a site of prostate cancer on PSMA-targeted positron emission tomography (PET). In recent years, this system has extensively been investigated. Increasing evidence has accumulated that the different categories reflect their actual meanings, such as true positivity in PSMA-RADS 4 and 5 lesions. Interobserver agreement studies demonstrated high concordance among a broad spectrum of <sup>68</sup>Ga- or <sup>18</sup>F-labeled, PSMA-directed radiotracers, even for less experienced readers. Moreover, this system has also been applied to challenging clinical scenarios and to assist in clinical decision-making, for example, to avoid overtreatment in oligometastatic disease. Nonetheless, with an increasing use of PSMA-RADS 1.0, this framework has shown not only benefits, but also limitations, for example, for follow-up assessment of locally treated lesions. Thus, we aimed to update the PSMA-RADS framework to include a refined set of categories in order to optimize lesion-level characterization and best assist in clinical decision-making (PSMA-RADS version 2.0).
Bioengineered lungs generated from human i PSC s‐derived epithelial cells on native extracellular matrix (2017)

The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequent implantation. However, finding a reliable cell source and the ability to scale up for recellularization of the lung scaffold still remain significant challenges. To explore the possibility of regeneration of human lung tissue from stem cells in vitro, populations of lung progenitor cells were generated from human iPSCs. To explore the feasibility of producing engineered lungs from stem cells, we repopulated decellularized human lung and rat lungs with iPSC-derived epithelial progenitor cells. The iPSCs-derived epithelial progenitor cells lined the decellularized human lung and expressed most of the epithelial markers when were cultured in a lung bioreactor system. In decellularized rat lungs, these human-derived cells attach and proliferate in a manner similar to what was observed in the decellularized human lung. Our results suggest that repopulation of lung matrix with iPSC-derived lung epithelial cells may be a viable strategy for human lung regeneration and represents an important early step toward translation of this technology.
Семантики взаимодействия с отказами, дивергенцией и разрушением. Часть 1. Гипотеза о безопасности и безопасная конформность (2010)

The paper discusses methods of conformance testing of the given system to the given requirements (specification) basing on formal models. The operational semantics of an interaction is designated with a special testing machine formally defining various testing capabilities. A set of powerful and meaningful capabilities reducible to observation of external actions and refusals (absence of external actions) is selected. The innovations are: 1) Parameterization of the semantics with the kinds of observable and unobservable refusals that allows taking into account various restrictions on (correct) interaction. 2) Destruction as a forbidden action, which is possible, but should not be performed in a correct interaction. 3) Modeling of divergence with a ∆-action which also should be avoided in a correct interaction. The notion of safe testing, the implementation hypothesis of safety and relation of safe conformance based on such semantics are proposed. Theoretically, test generation from specification given in arbitrary interaction semantics of the studied kind is considered. The parameterized R/Q-semantics of interaction, hypothesis of safety, safe conformance and the method of test generation proposed in this paper are the basis of the conformance theory that generalizes many of the conformances and testing methods found in literature and used in practice. Particularly, failure trace semantics and the semantics of the popular ioco relation are the instances of the R/Q-semantics. This theory is now developed in various directions. 1) Specification completion solving the problem of specification nonreflexivity in respect to conformance relation as well as the problem of safe specification traces that can not be found in conformant implementations and test traces that can not be found in safely tested implementations. 2) Monotonous transformation of the specification solving the problem of verification of the given system specification (its consistency with the components specifications). 3. Introduction of priorities into the model and the corresponding modification of conformance and test generation. 4) Propagation of suggested approach on simulations conformances based not only on the traces of observations, but also on the correspondence of the states in implementation and specification. The issues of equivalence of interaction semantics and semantics transformations during testing using the mediator programs converting test stimuli and observations are also researched.
Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control (2008)

Members of the mitogen-activated protein kinase (MAPK) subfamily responsive to environmental stress stimuli are known as SAPKs (stress-activated protein kinases), which are conserved from yeast to humans. In the fission yeast Schizosaccharomyces pombe, Spc1/Sty1 SAPK is activated by diverse forms of stress, such as osmostress, oxidative stress and heat shock, and induces gene expression through the Atf1 transcription factor. Sin1 (SAPK interacting protein 1) was originally isolated as a protein that interacts with Spc1, and its orthologs were also found in diverse eukaryotes. Here we report that Sin1 is not required for the stress gene expression regulated by Spc1 and Atf1, and that Sin1 is an essential component of TOR (target of rapamycin) complex 2 (TORC2). TORC2 is not essential for cell viability in S. pombe but plays important roles in cellular survival of stress conditions through phosphorylation and activation of an AGC-family protein kinase, Gad8. In addition, inactivation of Gad8 results in a synthetic growth defect with cdc25-22, a temperature-sensitive mutation of the Cdc25 phosphatase that activates Cdc2 kinase at G(2)/M. Gad8 also positively regulates expression of the CDK inhibitor gene rum1+, which is essential for cell cycle arrest in G(1) after nitrogen starvation. These results strongly suggest that the TORC2-Gad8 pathway has multiple physiological functions in cellular stress resistance and cell cycle progression at both G(1)/S and G(2)/M transitions.
Abstract 397: SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines (2019)

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor type with poor prognosis and limited treatment options. In this study, we aimed to discover potential novel drug targets using a pooled epigenome sgRNA viability screen in a panel of ESCC cell models. We identify the BAF chromatin remodeling helicase subunit SMARCA4/BRG1 as a novel dependency in a subset of ESCC cell lines. In line with the established synthetic lethal interaction of SMARCA4 and SMARCA2/BRM, the two mutual exclusive catalytic subunits of the BAF complex, SMARCA4-dependent cell lines display low or absent expression of SMARCA2. In rescue studies using SMARCA4 variants, we demonstrate that SMARCA4-dependency is linked to its ATPase/helicase activity, but not to bromodomain function. Similarly, ectopic expression of wild-type and bromodomain-mutant SMARCA2, but not a helicase-dead variant, rescues from loss of SMARCA4 in SMARCA2-low ESCC cells. SMARCA2-proficient ESCC cell models are rendered SMARCA4-dependent upon CRISPR/Cas9-mediated knock-out of SMARCA2. We further identify SMARCA4-dependent cell models from additional tumor types (colon, ovarian and pancreas carcinoma) with low or absent SMARCA2 expression. These findings expand the concept of SMARCA2/SMARCA4 paralog dependency and indicate pharmacological inhibition of SMARCA4 as a novel opportunity for targeted therapy of SMARCA2-deficient cancers. Citation Format: Katharina Ehrenhöfer-Wölfer, Teresa Puchner, Silvia Blaha-Ostermann, Alexandra Hörmann, Wolfgang Sommergruber, Norbert Schweifer, Thomas Zichner, Andreas Schlattl, Ralph A. Neumüller, Manfred Koegl, Mark P. Petronczki, Mark Pearson, Simon Wöhrle. SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 397.
Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization (2016)

Dynamic epigenetic reprogramming occurs during normal embryonic development at the preimplantation stage. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term consequences. Among these, the skewed sex ratio, an indicator of reproductive hazards, was reported in bovine and porcine embryos and even human IVF newborns. However, since the first case of sex skewing reported in 1991, the underlying mechanisms remain unclear. We reported herein that sex ratio is skewed in mouse IVF offspring, and this was a result of female-biased peri-implantation developmental defects that were originated from impaired imprinted X chromosome inactivation (iXCI) through reduced ring finger protein 12 (Rnf12)/X-inactive specific transcript (Xist) expression. Compensation of impaired iXCI by overexpression of Rnf12 to up-regulate Xist significantly rescued female-biased developmental defects and corrected sex ratio in IVF offspring. Moreover, supplementation of an epigenetic modulator retinoic acid in embryo culture medium up-regulated Rnf12/Xist expression, improved iXCI, and successfully redeemed the skewed sex ratio to nearly 50% in mouse IVF offspring. Thus, our data show that iXCI is one of the major epigenetic barriers for the developmental competence of female embryos during preimplantation stage, and targeting erroneous epigenetic modifications may provide a potential approach for preventing IVF-associated complications.
Supplementary Figure 2 from BET Bromodomain Inhibition of <i>MYC</i>-Amplified Medulloblastoma (2023)

&lt;p&gt;PDF file - 386K, A, Cell viability relative to day 0 is shown following the indicated treatments in the indicated cell lines. Error bars represent the mean plus-minus SD of three replicates per condition. B, qPCR assessment of MYC mRNA expression in three MYC-amplified patient derived medulloblastoma cell lines treated with JQ1R or JQ1S at doses shown. Values represent mean plus-minus SD of six replicate measurements.&lt;/p&gt;
Low temperature CMOS experience at IBM (2002)

Using as a basis experience gained at IBM, the author discusses how low temperature cooling will take on more focus in the future as the computer industry speeds toward increased chip power levels. The systems that have been designed with low temperature vapor compression cycles have shown that this technology provides a viable cooling technique for the future.
A Flow-compartmental Model To Measure Glucose Transport And Insulin Control Upon It In The Human Skeletal Muscle (2005)

Glucos transport into (k. , min ) and out (kou , mine’) of the cell in #e human skeletal muscfe is a critical step of glucose metabolism. Its measurement in humans is however difficult both in terms of experimental design and kinetic data analysis. Here we present a linear model for measuring glucose transport in the human forearm skeletal muscle from a multiple tracer dilution experiment. The model is a partly-flow compartmental model which describes not only glucose transport kinetics but also blood flow heterogeneity. It consists of three parallel chains of compartments to which cellular compartments are appended. k. and k can be precisely estimated from the dips. We ?’f:st use the model to measure kin and k at various insulin levels in the normal state: tgZtmodel - cons truc ted dose - response curve reveals an asymetrical effect of insulin on k and k . Then we show results on glucose @ansportoUfn diabetics under similar circumstances: the model kin reveals the inability of insulin to stimulate and k These new model-based findings are releva%!t‘both for the physiology of glucose transport in vivo as well for diabetes therapy.
INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS (2015)

In ERM eyes with connecting strands, intraoperative spectral domain optical coherence tomography imaging showed moderately to highly reflective sub-ILM finger-like lesions that persist immediately after membrane and ILM peeling. Postoperatively, the hyperreflective lesions disappeared spontaneously without localized nerve fiber layer loss. The sub-ILM connecting strands may represent glial retinal attachments.
D523, Part 1. Single and Dual Multi-Sensor Channel Characterisation - Analysis and Models : Stochastic Models (2001)

D523, Part 1. Single and Dual Multi-Sensor Channel Characterisation - Analysis and Models : Stochastic Models