gebhart/patrepeval huggingface dataset:
Chemically Exfoliated MoS2 as Near‐Infrared Photothermal Agents (2013)

Zweidimensionales Biodynamit: Chemisch abgetragenes MoS2 (ceMoS2), ein in Wasser dispergierbares, blattförmiges Material, ist ein effizienter photothermischer Nah-Infrarot(NIR)-Energieumwandler. Die ausgezeichneten bio-supramolekularen Eigenschaften von ceMoS2 und die Fähigkeit dieses Materials, biomolekulare Zielstrukturen durch NIR-photothermische Transduktion zu zerstören, wurden untersucht (siehe Bild). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Behavioral modeling of envelope tracking power amplifier using Volterra series model and compressed sampling (2015)

Radio frequency power amplifiers operate most efficiently in the compression region and become less efficient as signal peak-to-average power ratio increases. This is due to the amplifier spending more time operating below peak power and, thus operating below its maximum efficiency. However, the use of the envelope tracking technique can dramatically increase the efficiency of RF transmitters. In this work, a Volterra series-based behavioral model with compressed sampling is developed for an efficiency optimized envelope tracking power amplifier. The proposed method reduces the total number of coefficients needed by the Volterra series model and enables accurate behavioral modeling of nonlinear envelope tracking power amplifiers. Experimental results carried on a GaN based power amplifier driven by a four-carrier 18 MHz WCDMA signal demonstrate the effectiveness of the proposed model and approach.
THE SECURE COMMUNICATIONINTEROPERABILITYPROTOCOL (SCIP) OVERA VHFIUHF RADIO CHANNEL (2008)

The Secure Communication Interoperability Protocol (SCIP) is a newly emerging application layer interoperability standard that is being developed for secure voice and data communication between international coalition partners. It was designed to operate independently of the characteristics of underlying media layers. This paper will present the results of an investigation into the performance of the SCIP Point to Multi-Point Protocol over a VHF radio Narrowband Channel and the SCIP Point to Point Protocol over a VHF Wideband Channel. An Over the Airfield demonstration using the Harris AN/PRC-117GMultiband Manpack was designed and is described. Voice qualityperformance data was gathered over a range of radio configurations and channel conditions. Performance data is presented along with discussion and recommendationson future work.
Hard Pd Nanorods in the Soft Surfactant Mixture of CTAB and Pluronics: Seedless Synthesis and Their Self-Assembly (2018)

Seedless synthesis of Pd nanorods and their self-assembly into the layered smectic ordering are described. Aqueous Pluronic triblock copolymers (14.3-35.7%) are used as a soft template along with cetyltrimethylammonium bromide for inducing one-dimensional growth of Pd nanorods. Pluronic triblock copolymers are probably the most used polymer surfactants, and they are composed of poly(ethylene oxide) (PEO)-poly(propylene oxide) (PPO)-PEO triblocks. Neither pH adjustment nor AgNO<sub>3</sub> and other additives, such as poly(vinyl pyrrolidone) and ethylene glycol, are required to obtain Pd nanorods. Sonochemical synthesis at 43 °C, followed by thermal annealing for 1 h at 65 °C produces Pd nanorods with the aspect ratio from 3.1 (17.9%, Pluronic L-64) to 6.7 (35.7%, Pluronic P-123). Two-dimensional self-assembly of the nanorods is observed, and both nematic ordering between the mesogens and smectic ordering between the layers is identified. Micellar hydrophobic PPO with hydrated PEO coronas are known to self-assemble into many crystalline orders, including cubic, hexagonal, lamellar, and inverse hexagonal mesophases, which extend into cylindrical micelles with increasing temperature. Relatively small size of Pluronic copolymers with regard to general polymers, but rather large size of their micelles and their tendency to organize into crystalline mesophases are thought to contribute to the anisotropic growth of Pd nanorods.
SIRTUIN-2 IS REGULATED BY SERUM RESPONSE FACTOR AND P49/STRAP GENES (2017)

Introduction: Serum response factor (SRF) has been implicated in the regulation of cell growth, proliferation and senescence. SRF regulates its target genes by binding to the serum response element (SRE or CArG-box) with “CC(A/T)6GG” sequence. SRF interacts with SRF-binding protein(s), including p49/STRAP (SRFBP1), to co-regulate SRF-target genes. Hypothesis: The CArG-sequence exists not only in cytoskeletal genes but also in other genes. Since p49/STRAP, an SRF-binding protein, alters NAD/NADH ratio and affects histone protein deacetylation, we hypothesized that the CArG-sequence may exist in the promoter of sirtuin genes, and that SIRT2 may be regulated by SRF and p49/STRAP. Methods and Results: Using bioinformatic analysis, we found a classic CArG-box sequence in the promoter of SIRT2 gene (accession no. AC011455). Sequencing analysis of five human DNA samples confirmed that all DNA samples had the same CArG-box sequence. Electrophoretic mobility shift assay showed that SRF protein indeed bound to P32-labeled SIRT2 promoter probe. A luciferase vector containing the SIRT2 promoter was constructed and used for transfection assays. The SIRT2 gene promoter was activated by SRF and myocardin, but repressed by p49/STRAP. Serum starvation also changed SIRT2 mRNA levels. Conclusion: The SRF protein binds to the SIRT2 gene promoter and regulates SIRT2 gene expression, thus the SIRT2 gene is a SRF-target gene. SIRT2 gene is modulated by p49/STRAP and myocardin through interactions with SRF. The age-associated increases in cardiac SRF and p49/STRAP protein levels likely affect SIRT2 gene expression and induce histone protein deacetylation, thereby contributing to SIRT2-mediated aging in the heart.
Synthesis and Characterization of Abasic β-Diol-C-Nucleosides (2023)

Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein, we describe the synthesis of a novel β-C-nucleoside bearing a diol group at anomeric position, amenable as a metal ligand or organocatalyst. An abasic ligand was successfully prepared and inserted into a complementary DNA strand.
Search for dark matter in events with missing transverse momentum and a Higgs boson decaying into two photons in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector (2021)

A bstract A search for dark-matter particles in events with large missing transverse momentum and a Higgs boson candidate decaying into two photons is reported. The search uses 139 fb − 1 of proton-proton collision data collected at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV with the ATLAS detector at the CERN LHC between 2015 and 2018. No significant excess of events over the Standard Model predictions is observed. The results are interpreted by extracting limits on three simplified models that include either vector or pseudoscalar mediators and predict a final state with a pair of dark-matter candidates and a Higgs boson decaying into two photons.
Nonlinear adaptive noise compensation in electrogastrograms recorded from healthy dogs (2000)

Adaptive noise compensation is a popular method for improving signal-to-noise ratio in a variety of biomedical applications with its major disadvantage being the requirement for a reference channel containing noise strongly correlated to the noise in the primary channel. In many biomedical applications the utilization of a channel containing such noise without any representation of the information signal is difficult if not impossible. In this study we investigated the possibility of applying adaptive compensation in nonideal noise environments containing substantial presence of information signal in the reference channel. The signal in the reference channel was subjected to nonlinear manipulations for reducing the signal-to-noise ratio, thus diminishing the representation of information signal. The methodology was tested on canine electrogastrographic (EGG) signals of four unconscious dogs which underwent laparotomy and implantation of six pairs internal stainless steel electrodes in addition to the eight-channel abdominal EGG. Fourteen-channel (six internal and eight cutaneous) were obtained from each dog for 1/2 h. The signals were digitized and processed by computer. All internal signals showed regular and coupled gastric electrical activity with frequency of repetition in the normogastric range [3-9 cycles-per-minute (cpm)]. A single pair of primary and reference channels was selected from each cutaneous recording and exponential manipulators in the reference channels were introduced. The manipulators were tuned to maximize the percent distribution of spectral components in the canine normogastric range of each frequency spectrum calculated from the signal at the output of the adaptive compensator. Significant increment in the percent distributions in the normogastric range (p < 0.01) was noted after tuning the exponential manipulator, and in many frequency spectra the recovery of the genuine dominant frequency peak of gastric electrical activity as determined by the internal recordings was noted. This study indicated that low percent distributions registered by some EGG channels are related to external nonlinear factors, the impact of which can be partially compensated.
Discovering the Active Sites for C3 Separation in MIL‐100(Fe) by Using Operando IR Spectroscopy (2012)

A reducible MIL-100(Fe) metal-organic framework (MOF) was investigated for the separation of a propane/propene mixture. An operando methodology was applied (for the first time in the case of a MOF) in order to shed light on the separation mechanism. Breakthrough curves were obtained as in traditional separation column experiments, but monitoring the material surface online, thus providing evidences on the adsorption sites. The qualitative and quantitative analyses of Fe(II) and, to some extent, Fe(III) sites were possible, upon different activation protocols. Moreover, it was possible to identify the nature and the role of the active sites in the separation process by selective poisoning of one family of sites: it was clearly evidenced that the unsaturated Fe(II) sites are mainly responsible for the separation effect of the propane/propene mixture, thanks to their affinity for the unsaturated bonds, such as the C=C entities in propene. The activity of the highly concentrated Fe(III) sites was also highlighted.
Pulse Electric Current–Aided Reactive Sintering of High‐Purity Zr 3 Al 3 C 5 (2014)

Herein, we report on the in situ reactive synthesis and simultaneous densification of a high‐purity ternary Zr 3 Al 3 C 5 phase via pulse electric current sintering ( PECS ) of Zr / Al /graphite powder mixtures with a molar ratio of 3:3.2:4.8. The phases and microstructure evolution in the 580°C–1800°C temperature range were characterized by X ‐ray diffraction, real‐time sintering curves, and a scanning electron microscope equipped with an energy dispersive spectroscope. An additive‐free, fully dense Zr 3 Al 3 C 5 compound was obtained at 1800°C using a load corresponding to a stress of 35 MPa for 20 min. The final product was comprised of 96.61 wt% Zr 3 Al 3 C 5 , 3.14 wt% ZrC , and 0.25 wt% Zr 2 Al 3 C 4 ; the relative density was 97%.
Looking for trouble (2008)

This paper presents a method for mining potential troubles or obstacles related to the use of a given object. Some example instances of this relation are (medicine, side effect) and (amusement park, height restriction). Our acquisition method consists of three steps. First, we use an un-supervised method to collect training samples from Web documents. Second, a set of expressions generally referring to troubles is acquired by a supervised learning method. Finally, the acquired troubles are associated with objects so that each of the resulting pairs consists of an object and a trouble or obstacle in using that object. To show the effectiveness of our method we conducted experiments using a large collection of Japanese Web documents for acquisition. Experimental results show an 85.5% precision for the top 10,000 acquired troubles, and a 74% precision for the top 10% of over 60,000 acquired object-trouble pairs.
Animal models for ebolavirus countermeasures discovery: what defines a useful model? (2015)

Animal models of EHF varying from rodents to NHP species are currently under evaluation for their reproducibility and utility for modeling infection in humans. Complete development and licensure of therapeutic agents and vaccines will require demonstration that mechanisms conferring protection in NHP models of infection are predictive of protective responses in humans, for a given countermeasure.
Comparative analysis reveals amino acids critical for anticancer activity of peptide CIGB-552 (2016)

Because of resistance development by cancer cells against current anticancer drugs, there is a considerable interest in developing novel antitumor agents. We have previously demonstrated that CIGB-552, a novel cell-penetrating synthetic peptide, was effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Studies of protein-peptide interactions have shown that COMMD1 protein is a major mediator of CIGB-552 antitumor activity. Furthermore, a typical serine-protease degradation pattern for CIGB-552 in BALB/c mice serum was identified, yielding peptides which differ from CIGB-552 in size and physical properties. In the present study, we show the results obtained from a comparative analysis between CIGB-552 and its main metabolites regarding physicochemical properties, cellular internalization, and their capability to elicit apoptosis in MCF-7 cells. None of the analyzed metabolites proved to be as effective as CIGB-552 in promoting apoptosis in MCF-7. Taking into account these results, it seemed important to examine their cell-penetrating capacity and interaction with COMMD1. We show that internalization, a lipid binding-dependent process, is impaired as well as metabolite-COMMD1 interaction, key component of the apoptotic mechanism. Altogether, our results suggest that features conferred by the amino acid sequence are decisive for CIGB-552 biological activity, turning it into the minimal functional unit. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
A sigma-delta DC-DC converter (2007)

A switching DC-DC converter is proposed that uses a Sigma-Delta Modulator (SDM) in place of the usual Pulse Width Modulator (PWM). One type of control method, voltage mode control used for switching regulators involves sensing the output voltage to servo the loop to regulate the output. Voltage mode control has inherently bad line response, which is the ability to filter out changes on the input so they don’t reach the output. The typical method to improve this response can put more noise on the output when a steady state ripple is present. The proposed architecture provides an advantage over a PWM based converter in that it does not put as many harmonics in the low frequency range when steady state ripple is present on the input.
A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-κB Activation by API2·MALT1 Fusions (2007)

The recurrent translocation t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue (MALT) lymphoma results in the expression of an API2.MALT1 fusion protein that constitutively activates NF-kappaB. The first baculovirus IAP repeat (BIR) domain of API2 and the C terminus of MALT1, which contains its caspase-like domain, are present in all reported fusion variants and interact with TRAF2 and TRAF6, respectively, suggesting their contribution to NF-kappaB signaling by API2.MALT1. Also, the involvement of BCL10 has been suggested via binding to BIR1 of API2 and via its interaction with the immunoglobulin domains of MALT1, present in half of the fusion variants. However, conflicting reports exist concerning their roles in API2.MALT1-induced NF-kappaB signaling. In this report, streptavidin pulldowns of biotinylated API2.MALT1 fusion variants showed that none of the fusion variants interacted with endogenous BCL10; its role in NF-kappaB signaling by API2.MALT1 was further questioned by RNA interference experiments. In contrast, TRAF6 was essential for NF-kappaB activation by all fusion variants, and we identified a novel TRAF6 binding site in the second immunoglobulin domain of MALT1, which enhanced NF-kappaB activation when present in the fusion protein. Furthermore, inclusion of both immunoglobulin domains in API2.MALT1 further enhanced NF-kappaB signaling via intramolecular TRAF6 activation. Finally, binding of TRAF2 to BIR1 contributed to NF-kappaB activation by API2.MALT1, although additional mechanisms involving BIR1-mediated raft association are also important. Taken together, these data reveal distinct mechanisms of NF-kappaB activation by the different API2.MALT1 fusion variants with an essential role for TRAF6.
High voltage electrical discharges followed by deep eutectic solvents extraction for the valorization of pomegranate seeds (Punica granatum L.) (2022)

This work proposes a sustainable methodology based on the use of high voltage electrical discharges (HVED) and deep eutectic solvents (DES) for the simultaneous extraction of proteins and polyphenols from pomegranate seeds. Pomegranate seeds were firstly pretreated with HVED and, next, submitted to a solid-liquid extraction using DES. HVED pretreatment was compared with ultrasounds observing a better performance of HVED that promoted the disintegration of 86% of cells at 160 kJ/kg energy input and, consequently, the release of 70% of proteins and 78% of polyphenols. Extraction/solubilization of proteins and polyphenols was carried out using 5 different DES and results were compared with the obtained using NaOH. DES improved the diffusivity of both proteins and polyphenols, although the highest rates were observed for proteins, while NaOH extracted higher amounts of both. Application of RP-HPLC-ESI-Q-TOF to the analysis of extracts enabled to identify 30 different phenolic compounds among extracts, most of them ellagitannins. Proteomics enabled to identity a total of 11 different proteins among pomegranate seed extracts that were mainly assigned to globulins and albumins, with nutrient reservoir activity.
A rapid, low-cost, and highly sensitive SARS-CoV-2 diagnostic based on whole-genome sequencing (2020)

Abstract Early detection of infection with SARS-CoV-2 is key to managing the current global pandemic, as evidence shows the virus is most contagious on or before symptom onset. Here, we introduce a low-cost, high-throughput method for diagnosing and studying SARS-CoV-2 infection. Dubbed Pathogen-Oriented Low-Cost Assembly &amp; Re-Sequencing (POLAR), this method amplifies the entirety of the SARS-CoV-2 genome. This contrasts with typical RT-PCR-based diagnostic tests, which amplify only a few loci. To achieve this goal, we combine a SARS-CoV-2 enrichment method developed by the ARTIC Network ( https://artic.network/ ) with short-read DNA sequencing and de novo genome assembly. Using this method, we can reliably (&gt;95% accuracy) detect SARS-CoV-2 at a concentration of 84 genome equivalents per milliliter (GE/mL). Almost all diagnostic methods currently authorized for use by the United States Food and Drug Administration with the Coronavirus Disease 2019 (COVID-19) Emergency Use Authorization require larger concentrations of the virus to achieve this degree of accuracy. In addition, we can reliably assemble the SARS-CoV-2 genome in the sample, often with no gaps and perfect accuracy. The genotypic data contained in these genome assemblies enable the more effective analysis of disease spread than is possible with an ordinary binary diagnostic. These data can also help identify vaccine and drug targets. Finally, we show that the diagnoses obtained using POLAR of both positive and negative clinical nasopharyngeal swab samples 100% match the diagnoses obtained in a clinical diagnostic lab using the Center for Disease Control’s 2019-Novel Coronavirus test. Using POLAR, a single person can manually process 192 samples over an 8- hour experiment at the cost of ∼$36 per patient (as of December 7 th , 2022), enabling a 24-hour turnaround with sequencing and data analysis time. We anticipate that further testing and refinement will allow greater sensitivity in this approach.
Identification of the Imprinted KLF14 Transcription Factor Undergoing Human-Specific Accelerated Evolution (2007)

Imprinted genes are expressed in a parent-of-origin manner and are located in clusters throughout the genome. Aberrations in the expression of imprinted genes on human Chromosome 7 have been suggested to play a role in the etiologies of Russell-Silver Syndrome and autism. We describe the imprinting of KLF14, an intronless member of the Krüppel-like family of transcription factors located at Chromosome 7q32. We show that it has monoallelic maternal expression in all embryonic and extra-embryonic tissues studied, in both human and mouse. We examine epigenetic modifications in the KLF14 CpG island in both species and find this region to be hypomethylated. In addition, we perform chromatin immunoprecipitation and find that the murine Klf14 CpG island lacks allele-specific histone modifications. Despite the absence of these defining features, our analysis of Klf14 in offspring from DNA methyltransferase 3a conditional knockout mice reveals that the gene's expression is dependent upon a maternally methylated region. Due to the intronless nature of Klf14 and its homology to Klf16, we suggest that the gene is an ancient retrotransposed copy of Klf16. By sequence analysis of numerous species, we place the timing of this event after the divergence of Marsupialia, yet prior to the divergence of the Xenarthra superclade. We identify a large number of sequence variants in KLF14 and, using several measures of diversity, we determine that there is greater variability in the human lineage with a significantly increased number of nonsynonymous changes, suggesting human-specific accelerated evolution. Thus, KLF14 may be the first example of an imprinted transcript undergoing accelerated evolution in the human lineage.
Content-type coding (2015)

This paper is motivated by the observation that, in many cases, we do not need to serve specific messages, but rather, any message within a content-type. Content-type traffic pervades a host of applications today, ranging from search engines and recommender networks to newsfeeds and advertisement networks. The paper asks a novel question: if there are benefits in designing network and channel codes specifically tailored to content-type requests. It provides three examples of content-type formulations to argue that, indeed in some cases we can have significant such benefits.
ChemInform Abstract: Synthesis of a New Unnatural Amino Acid with a Benzodiazepine‐ Containing Side Chain and Incorporation into a Tripeptide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.