gebhart/patrepeval huggingface dataset:
A Case of Tsutsugamushi Disease Which Occurred in South Western Shikoku (1995)

We report a case of tsutsugamushi disease found in south western Shikoku. A 64-year-old male who lived in Towa Village in Kochi, developed a fever and headache on April 6, 1994, and was admitted to Uwajima City Hospital on April 15, with a ten-day history of illness. He had an eschar on the right anterior side of the breast and an enlargement of the right axillary lymph node, without a rash. Laboratory data showed mild liver injury and atypical lymphocytes with 6% in peripheral blood. After his blood was drawn for rickettsial isolation, the minocycline was administered. His symptoms improved rapidly and was discharged in good condition. We successfully isolated the causative agent, Rickettsia tsutugamushi, and designated it as the Shiba strain. High antibody titer against the Kato, Karp and Gilliam strains was detected in serum on admission and increased during the course of the disease. In Shikoku, tsutsugamushi disease is rare and only 13 cases were reported during last ten years. Especially in south western district of Shikoku, there have been no case reported since 1960. This case is important epidemiologically and suggests that we should pay attention to this disease.
The influence of chair height on lower limb mechanics during rising (1989)

The mechanics of the lower limb were analyzed in young, adult normal subjects when rising from a seated position. Limb mechanics were described in terms of flexion-extension motion and moments at the hip, knee and ankle while rising from four seat heights corresponding to 65, 80, 100, and 115% of the subject's knee joint height. The results indicate that the maximum moment tending to flex the hip joint was higher than that occurring at the knee or ankle. The magnitude of the maximum flexion moment at the hip was not substantially influenced by chair height, changing by less than 12% between the highest and lowest chair heights. Conversely, the maximum knee flexion moments were found to be highly dependent on chair height and nearly doubled from the highest to the lowest position. The magnitude of the moments at the ankle did not change with chair height and were significantly lower than the magnitude of the moments found during normal walking. The magnitude of motion and moments at the hip were greater during chair-rising than during stair-climbing or walking. The range of motion required at the knee for the lower chair heights was also greater than was reported during stair-climbing studies. Thus, the combination of moments in joint angles during chair-rising are unique among common activities of daily living and should be considered in chair selection as well as in the guidelines for prosthetic devices.
Designing evanescent optical interactions to control the expression of Casimir forces in optomechanical structures (2011)

We propose an optomechanical structure consisting of a photonic-crystal (holey) membrane suspended above a layered silicon-on-insulator substrate in which resonant bonding/antibonding optical forces created by externally incident light from above enable all-optical control and actuation of stiction effects induced by the Casimir force. In this way, one can control how the Casimir force is expressed in the mechanical dynamics of the membrane, not by changing the Casimir force directly but by optically modifying the geometry and counteracting the mechanical spring constant to bring the system in or out of regimes where Casimir physics dominate. The same optical response (reflection spectrum) of the membrane to the incident light can be exploited to accurately measure the effects of the Casimir force on the equilibrium separation of the membrane.
Image mosaicing with automatic scene segmentation for video indexing (2003)

An image mosaicing algorithm for video indexing is presented with efficient and robust automatic scene segmentation. Phase correlation and motion compensation are used for image mosaicing and scene segmentation. Simulation results show that the proposed algorithm is fast, robust and efficient for scene-based video indexing.
Si-like low-frequency noise characteristics of 4H-SiC MOSFETs (2011)

The 1/f noise in 4H-SiC MOSFETs with epitaxial channel has been investigated systematically for the first time. It was shown that in the samples with NO post-oxidation annealing and epitaxial channel, the dependence of noise on gate voltage has a 'classical' Si-like form. Such a kind of dependence manifests that the density of negative oxide traps responsible for 1/f noise, Ntv, does not depend on Ec–EF (Ec is a position of the bottom of conductivity band; EF is a position of the Fermi level). The Ntv was found to be ~ 2 × 1019 cm−3 eV−1. Interface trap density and its dependence on energy position, Dit(Ec–EF), were extracted from temperature dependences of the threshold voltage Vt and from transfer current–voltage characteristics in the subthreshold regime.
Induction of apoptosis by sarijang, a bamboo salt sauce, in U937 human leukemia cells through the activation of caspases (2013)

Sarijang is a bamboo salt soy sauce, containing extracts of <i>Rhynchosia nulubilis</i>, sulfur-fed duck, dried bark of <i>Ulmus davidiana</i> and <i>Allium sativum</i>, which has been demonstrated to exert anti-inflammatory and antitumor activity. However, the cellular and molecular mechanisms of action of sarijang have not yet been elucidated. In the present study, we investigated the pro-apoptotic effects of sarijang in an <i>in vitro</i> U937 human leukemia cell model. Treatment with sarijang resulted in a concentration-dependent growth inhibition of the cells, coupled with the characteristic morphological features of apoptosis. The induction of the apoptotic cell death of the U937 cells by sarijang exhibited a correlation with the upregulation of death receptor 4 (DR4), the downregulation of members of the inhibitor of apoptosis protein (IAP) family, including survivin and cellular IAP (cIAP)-1, and the cleavage of Bid. Apoptosis-inducing concentrations of sarijang also induced the activation of caspases (caspase-3, -8 and -9), accompanied by proteolytic degradation of poly(ADP-ribose)-polymerase, β-catenin and phospholipase C-γ1. However, the apoptosis induced by sarijang was significantly inhibited by z-VED-fmk, a pan-caspase inhibitor, which demonstrated the importance of caspases in the process. These results suggested that sarijang may be a potential chemotherapeutic agent for use in the control of U937 human leukemia cells. Further studies are required to identify the active compounds in sarijang.
Glucose Specific GDH-PQQ based Sensor Strip: Application of Engineered GDH-PQQ Harboring a de novo Designed Loop Region (2011)

In response to an FDA Public Health Notification regarding the risk associated with the use of PQQGDH in glucose monitoring technology due to its broad substrate specificity, many manufacturers have switched to alternative enzymes. We present the challenges in the biomolecular engineering of PQQGDH and our achievement in the construction of an enzyme that is highly specific toward glucose. We designed a loop region that appears to sterically prevent the binding of disaccharides, such as maltose, into the substrate binding cavity. Combination of the designed loop region with previously generated mutations that were found to improve substrate specificity yielded enzymes that are virtually non-active toward maltose, while retaining sufficient activity toward glucose. A screen-printed carbon electrode employing thus developed engineered PQQGDH was capable of determining glucose concentrations with 0.5 µl sample within 5 seconds while barely responding to maltose. Our strategy and achievements are expected to overcome the enzyme's "maltose problems".
Room Temperature Ionic Liquid Promoted Improved and Rapid Synthesis of 2,4,5‐Triaryl Imidazoles from Aryl Aldehydes and 1,2‐Diketones or α‐Hydroxyketone. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis and characterization of new copolymers of thiophene and vinylene: Poly(thienylenevinylene)s and poly(terthienylenevinylene)s with thioether side chains (1999)

Poly[3,4-bis(3-methylbutylthio)thienylenevinylene], poly[3,4-bis-(S)-(2-methylbutylthio)thienylenevinylene], poly[3′,4′-bis(3-methylbutylthio)-2,2′:5′,2″-terthienylene-5,5″-vinylene], and poly{3′,4′-bis-(S)-[2-methylbutylthio]-2,2′:5′,2″-terthienylene-5,5″-vinylene} have been synthesized. The synthesis starts from the thiophene monomers and trimers, which are formylated to give the corresponding dialdehydes. The dialdehydes are reductively polymerized using a McMurry coupling. The polymers are characterized by GPC, optical spectroscopy (FT-IR, UV-vis, circular dichroism spectroscopy and photoluminescence) and by proton and carbon NMR spectroscopy. The polymers are soluble in common organic solvents, such as THF, chloroform, toluene, benzene and 1,2-dichlorobenzene. The solvatochromism and thermochromism of the polymers in solution are investigated, while the optical activity of the polymers is used to investigate the supramolecular aggregation. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 4629–4639, 1999
Tunable Optomechanical Cavity Filters (2019)

Cavity optomechanics enables large-scale index tuning (Δneff). However, most demonstrations exhibited small Δneff or have not considered optical loss at large Δneff. We demonstrate Δneff-tuning using gradient electric forces and analyze optomechanically-induced loss and mitigation.
Solution Structure of the SEA Domain from the Murine Homologue of Ovarian Cancer Antigen CA125 (MUC16) (2004)

Human CA125, encoded by the MUC16 gene, is an ovarian cancer antigen widely used for a serum assay. Its extracellular region consists of tandem repeats of SEA domains. In this study we determined the three-dimensional structure of the SEA domain from the murine MUC16 homologue using multidimensional NMR spectroscopy. The domain forms a unique alpha/beta sandwich fold composed of two alpha helices and four antiparallel beta strands and has a characteristic turn named the TY-turn between alpha1 and alpha2. The internal mobility of the main chain is low throughout the domain. The residues that form the hydrophobic core and the TY-turn are fully conserved in all SEA domain sequences, indicating that the fold is common in the family. Interestingly, no other residues are conserved throughout the family. Thus, the sequence alignment of the SEA domain family was refined on the basis of the three-dimensional structure, which allowed us to classify the SEA domains into several subfamilies. The residues on the surface differ between these subfamilies, suggesting that each subfamily has a different function. In the MUC16 SEA domains, the conserved surface residues, Asn-10, Thr-12, Arg-63, Asp-75, Asp-112, Ser-115, and Phe-117, are clustered on the beta sheet surface, which may be functionally important. The putative epitope (residues 58-77) for anti-MUC16 antibodies is located around the beta2 and beta3 strands. On the other hand the tissue tumor marker MUC1 has a SEA domain belonging to another subfamily, and its GSVVV motif for proteolytic cleavage is located in the short loop connecting beta2 and beta3.
µO-Conotoxins Inhibit NaVChannels by Interfering with their Voltage Sensors in Domain-2 (2007)

The muO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (Na(V)1.8) and could therefore serve as lead structure for novel analgesics. The aim of this study was to elucidate the molecular mechanism by which muO-conotoxins affect Na(V) channels. Rat Na(V)1.4 channels and mutants thereof were expressed in mammalian cells and were assayed with the whole-cell patch-clamp method. Unlike for the M-superfamily mu-conotoxin GIIIA from Conus geographus, channel block by MrVIA was strongly diminished after activating the Na(V) channels by depolarizing voltage steps. Searching for the source of this voltage dependence, the gating charges in all four-voltage sensors were reduced by site-directed mutagenesis showing that alterations of the voltage sensor in domain-2 have the strongest impact on MrVIA action. These results, together with previous findings that the effect of MrVIA depends on the structure of the pore-loop in domain-3, suggest a functional similarity with scorpion beta-toxins. In fact, MrVIA functionally competed with the scorpion beta-toxin Ts1 from Tityus serrulatus, while it did not show competition with mu-GIIIA. Ts1 and mu-GIIIA did not compete either. Thus, similar to scorpion beta-toxins, muO-conotoxins are voltage-sensor toxins targeting receptor site-4 on Na(V) channels. They "block" Na(+) flow most likely by hindering the voltage sensor in domain-2 from activating and, hence, the channel from opening.
Supplementary Table S3 from A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with <i>FGFR3</i> Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157 (2023)

&lt;p&gt;Supplementary Table S3: Baseline Tumor pFGFR3 IHC Intensity&lt;/p&gt;
BIPHASIC RESPONSIVENESS OF RAT PIAL ARTERIOLES TO DOPAMINE: DIRECT OBSERVATIONS ON THE MICROCIRCULATION (1980)

The effects of local perivascular application of dopamine to rat pial arterioles. (20-40 micrometer i.d.) were examined in situ, at the microcirculatory level, by use of a high-resolution closed circuit television microscope recording system. Local application of very low, physiological doses (1 to 10 pg) of dopamine to pial arterioles of the anaesthetized rat induces vasodilatation, whereas higher doses induce vasoconstriction. The magnitudes of these biphasic responses obtained in male rats were not significantly different from those obtained in female animals. Our findings support the theory that local release of this neurotransmitter amine from perivascular cells in the brain may promote local increases in cerebral blood flow.
Amphiphilic Anthracene-Amino Acid Conjugates as Simple Carbohydrate Receptors in Water (2002)

N -Alkylation of amino acid methyl esters with 9,10-bis-chloromethylanthracene, followed by methyl ester hydrolysis, yielded water-soluble amphiphilic amino acid-anthracene conjugates. In NMR-titration experiments, a l -arginine-anthracene conjugate was demonstrated to recognize p -nitrophenyl glycosides and sialylated oligosaccharides in D 2 O in a manner sensitive to the carbohydrate structure.
Millimeter Wave and Sub-Terahertz Spatial Statistical Channel Model for an Indoor Office Building (2021)

Millimeter-wave (mmWave) and sub-Terahertz (THz) frequencies are expected to play a vital role in 6G wireless systems and beyond due to the vast available bandwidth of many tens of GHz. This paper presents an indoor 3-D spatial statistical channel model for mmWave and sub-THz frequencies based on extensive radio propagation measurements at 28 and 140 GHz conducted in an indoor office environment from 2014 to 2020. Omnidirectional and directional path loss models and channel statistics such as the number of time clusters, cluster delays, and cluster powers were derived from over 15,000 measured power delay profiles. The resulting channel statistics show that the number of time clusters follows a Poisson distribution and the number of subpaths within each cluster follows a composite exponential distribution for both LOS and NLOS environments at 28 and 140 GHz. This paper proposes a unified indoor statistical channel model for mmWave and sub-Terahertz frequencies following the mathematical framework of the previous outdoor NYUSIM channel models. A corresponding indoor channel simulator is developed, which can recreate 3-D omnidirectional, directional, and multiple input multiple output (MIMO) channels for arbitrary mmWave and sub-THz carrier frequency up to 150 GHz, signal bandwidth, and antenna beamwidth. The presented statistical channel model and simulator will guide future air-interface, beamforming, and transceiver designs for 6G and beyond.
25 Tweets to Know You: A New Model to Predict Personality with Social\n Media (2017)

Predicting personality is essential for social applications supporting\nhuman-centered activities, yet prior modeling methods with users written text\nrequire too much input data to be realistically used in the context of social\nmedia. In this work, we aim to drastically reduce the data requirement for\npersonality modeling and develop a model that is applicable to most users on\nTwitter. Our model integrates Word Embedding features with Gaussian Processes\nregression. Based on the evaluation of over 1.3K users on Twitter, we find that\nour model achieves comparable or better accuracy than state of the art\ntechniques with 8 times fewer data.\n
A flexible algorithm for replicated directory management (2003)

A replicated directory management algorithm is presented that supports full location-transparency by allowing migration and reconfiguration at the granularity of individual names. Initially, all names in a directory (including names not yet in use) are controlled by the same set of sites, but control over any individual name (or range of names) can be migrated, e.g. to the set of sites that control the data object associated with the name. The method is based on a directory replication algorithm of J.J. Bloch et al. (1987), incorporating two extensions: (1) allowing control over individual names in a directory to migrate independently; and (2) allowing the definition of relationships among names, such that if control over a given name migrates, then those names that depend on it are automatically migrated as well. Finally, it is stated that the major cost of the algorithm, compared to simpler approaches that do not provide the same degree of location transparency, is the additional complexity and difficulty of obtaining a consistent view of the entire directory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
PSA density (PSAD). Role in patient evaluation and management. (1993)

Prostate Specific Antigen (PSA) is the most accurate serum marker for cancer of the prostate. However, sensitivity and specificity are suboptimal, especially at the intermediate levels between 4.1 and 10.0 ng/ml (monoclonal). For intermediate PSA levels, prostate specific antigen density (PSAD) provides unique information regarding the need for biopsy and the likelihood of prostate cancer. This article summarizes the utility of PSAD in diagnosing and treating prostate cancer.
CCDC 115799: Experimental Crystal Structure Determination (2000)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Assessment of wrought ASTM F1058 cobalt alloy properties for permanent surgical implants (1997)

The behavior of the ASTM F1058 wrought cobalt-chromium-nickel-molybdenum-iron alloy (commonly referred to as Elgiloy or Phynox) is evaluated in terms of mechanical properties, magnetic resonance imaging, corrosion resistance, and biocompatibility. The data found in the literature, the experimental corrosion and biocompatibility results presented in this article, and its long track record as an implant material demonstrate that the cobalt superalloy is an appropriate material for permanent surgical implants that require high yield strength and fatigue resistance combined with high elastic modulus, and that it can be safely imaged with magnetic resonance.
Synthesis and Characterization of Low-Melting, Highly Volatile Magnesium MOCVD Precursors and Their Implementation in MgO Thin Film Growth (2005)

A series of low-melting, highly volatile, and thermally/air stable diamine-coordinated magnesium metal−organic chemical vapor deposition (MOCVD) precursors, Mg(hfa)2(diamine) and Mg(hfa)3H(diamine) (hfa = 1,1,1,5,5,5-hexafluoro-2,4-pentanedionate), has been synthesized in a single-step aqueous reaction under ambient conditions, and the molecular structures have been determined by single-crystal X-ray diffraction. These fluorocarbon-bearing magnesium complexes exhibit significantly lower melting points and higher volatilities than most previously reported magnesium precursors for MgO thin film growth. One complex of the series, bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)(N,N,N‘,N‘-tetramethylethylenediamine)magnesium(II), with a low melting point (61 °C) and excellent volatility, was successfully implemented in MgO thin film growth by MOCVD. Phase-pure MgO thin films were deposited on Corning 1737F glass, single-crystal Si, and single-crystal SrTiO3(100) and -(110), over the temperature range 550−675 °C. It is demonstrated that highly (100)-oriented MgO films can be obtained on amorphous glass (X-ray diffraction fwhm = 3.1°). Compared to films on glass, epitaxial MgO thin films on both SrTiO3 substrates exhibit excellent out-of-plane alignment (fwhm = 0.7 and 0.9°) and good in-plane alignment. The microstructures, surface morphologies, and optical properties of the MgO thin films were also investigated as a function of growth temperature.
Standardised treatment and monitoring protocol to assess safety and tolerability of bacteriophage therapy for adult and paediatric patients (STAMP study): protocol for an open-label, single-arm trial (2022)

Registered on ANZCTR, 10 November 2021 (ACTRN12621001526864; WHO Universal Trial Number: U1111-1269-6000).
Small molecule detection by reflective interferometric Fourier transform spectroscopy (RIFTS) (2009)

Abstract A new method for the compensation of matrix effects in biosensing experiments referred to as reflective interferometric Fourier transform spectroscopy (RIFTS) has been developed recently [1]. It employs a porous silicon sensor comprised of two porous silicon layers stacked one on top of the other. The structure has a complicated reflectivity spectrum that can be resolved by FFT analysis leading to three distinctive peaks which are assigned to the layers in the porous silicon structur. If the double layer is appropriately designed, the bottom layer can act as a reference channel. In this paper the specific sensing of small molecules using RIFTS is demonstrated for the first time. Ac‐L‐Lys‐D‐Ala‐D‐Ala has been immobilized to the sensor surface representing the capture probe and vancomycin was used as target analyte. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B–NS3 proteases (2013)

A series of 45 peptide inhibitors was designed, synthesized, and evaluated against the NS2B-NS3 proteases of the four subtypes of dengue virus, DEN-1-4. The design was based on proteochemometric models for Michaelis (Km) and cleavage rate constants (kcat) of protease substrates. This led first to octapeptides showing submicromolar or low micromolar inhibitory activities on the four proteases. Stepwise removal of cationic substrate non-prime side residues and variations in the prime side sequence resulted finally in an uncharged tetrapeptide, WYCW-NH2, with inhibitory Ki values of 4.2, 4.8, 24.4, and 11.2 μM for the DEN-1-4 proteases, respectively. Analysis of the inhibition data by proteochemometric modeling suggested the possibility for different binding poses of the shortened peptides compared to the octapeptides, which was supported by results of docking of WYCW-NH2 into the X-ray structure of DEN-3 protease.
Shared Task on Evaluating Accuracy in Natural Language Generation (2020)

We propose a shared task on methodologies and algorithms for evaluating the accuracy of generated texts. Participants will measure the accuracy of basketball game summaries produced by NLG systems from basketball box score data.