gebhart/patrepeval huggingface dataset:
Modulation of the expression of interstitial and type-IV collagenases in coculture of HT1080 fibrosarcoma cells and fibroblasts. (1995)

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases (gelatinases A and B) in a model of coculture of human fibroblasts and HT 1080 fibrosarcoma cells. The interstitial collagenase activity, mainly found in the conditioned medium of fibroblasts, and its mRNA level were increased in the in vitro coculture model. In contrast, gelatinase A was produced by both cell types. The HT 1080 cells additionally synthesised gelatinase B. In coculture, an enhancement of gelatinase A and the presence of its activated form were observed. Northern blot analysis demonstrated that this enzymatic enhancement occurred at a pretranslational level. The stimulation of the interstitial collagenase activity was partially mediated through soluble factor(s), whereas increased gelatinase A appeared to require direct cell-cell interactions. The extracellular matrix component, type-I collagen, stimulated the enzymatic activities released by the individual cells, but it did not modulate the synthesis of interstitial collagenase in coculture. Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts.
In situ TPR XANES study of the partial oxidation of methane using a Ni-substituted hexaaluminate catalyst (2008)

Metallic Ni formation near the mirror cation site, Ba in this study, is believed to cause the partial oxidation activity observed in Ni-substituted hexaaluminate catalysts. The BaNi1.0Al11.6O19-d catalyst was prepared by coprecipitation with nitrate salt precursors; following the coprecipitation procedure, the catalyst was calcined at 1400°C to create the hexaaluminate structure. TPR XANES in fluorescence was used to probe the local structure of the BaNi1.0Al11.6O19-d catalyst to determine whether metallic nickel forms at different temperatures: 825°C, 875°C, 925°C. The XANES results indicate that the Ni in the hexaaluminate catalyst only reduces if the temperature is maintained at 925°C. Once the metallic state is formed, the oxidation state is stable; even in the POX environment. Future work using a theoretical approach to the XANES data using FEFF 8.4 gives information on the interactions between Ni and Ba, which will be used to further optimize the catalyst.
Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia (2019)

African swine fever (ASF) is a lethal hemorrhagic disease in domestic pigs and wild suids caused by African swine fever virus (ASFV), which threatens the swine industry globally. In its native African enzootic foci, ASFV is naturally circulating between soft ticks of the genus Ornithodoros, especially in the O. moubata group, and wild reservoir suids, such as warthogs (Phacochoerus spp.) that are bitten by infected soft ticks inhabiting their burrows. While the ability of some Afrotropical soft ticks to transmit and maintain ASFV is well established, the vector status of Palearctic soft tick species for ASFV strains currently circulating in Eurasia remains largely unknown. For example, the Iberian soft tick O. erraticus is a known vector and reservoir of ASFV, but its ability to transmit different ASFV strains has not been assessed since ASF re-emerged in Europe in 2007. Little is known about vector competence for ASFV in other species, such as O. verrucosus, which occurs in southern parts of Eastern Europe, including Ukraine and parts of Russia, and in the Caucasus. Therefore, we conducted transmission trials with two Palearctic soft tick species, O. erraticus and O. verrucosus, and the Afrotropical species O. moubata. We tested the ability of ticks to transmit virulent ASFV strains, including one of direct African origin (Liv13/33), and three from Eurasia that had been involved in previous (OurT88/1), and the current epizooties (Georgia2007/1 and Ukr12/Zapo). Our experimental results showed that O. moubata was able to transmit the African and Eurasian ASFV strains, whereas O. erraticus and O. verrucosus failed to transmit the Eurasian ASFV strains. However, naïve pigs showed clinical signs of ASF when inoculated with homogenates of crushed O. erraticus and O. verrucosus ticks that fed on viraemic pigs, which proved the infectiousness of ASFV contained in the ticks. These results documented that O. erraticus and O. verrucosus are unlikely to be capable vectors of ASFV strains currently circulating in Eurasia. Additionally, the persistence of infection in soft ticks for several months reaffirms that the infectious status of a given tick species is only part of the data required to assess its vector competence for ASFV.
Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo (2010)

"Contribution to neural and mesodermal lineages by porcine skin-derived progenitors (SKPs) in vivo." Cell Cycle, 9(10), pp. 2040–2041
A Novel and Versatile Calcium-Based Initiator System for the Ring-Opening Polymerization of Cyclic Esters (2001)

A novel and efficient calcium alkoxide initiating system, generated in situ from bis(tetrahydrofuran)calcium bis[bis(trimethylsilyl)amide] and an alcohol, for the ring-opening polymerization of cyclic esters has been developed. The solution polymerization in THF using mild conditions is living, yielding polyesters of controlled molecular weight and tailored macromolecular architecture. The polymerizations initiated with the 2-propanol−Ca[N(SiMe3)2]2(THF)2 system are first-order in monomer with no induction period. At high 2-propanol/Ca[N(SiMe3)2]2(THF)2 ratios, complete conversion of 2-propanol occurs due to fast and reversible transfer between dormant and active species.
Gut Microbiome-Derived Uremic Toxin Levels in Hemodialysis Patients on Different Phosphate Binder Therapies (2021)

There was no difference in the gut microbiome-derived UTOX levels between phosphate binders (SFO vs. SEV), despite SFO therapy resulting in fewer constipated participants. This pilot study may inform study design of future clinical trials and highlights the importance of including factors beyond bowel habits and their association with UTOX levels.
Epilepsy and Cognition in Childhood (2011)

Summary Idiopathic epilepsies in childhood normally appear at well distinct, characteristic ages and normally tend to disappear in most of the cases or to respond well to antiepileptic treatment without impairing the development of the child – this is the reason why they can be considered to have a good prognosis. Nevertheless an active epilepsy is able to take influence on congnitive networks, such as language and working memory, dependent on the localisation of focal epileptic discharges. 2 main studies of the UKBB team of pediatric neurology and development are presented which are dedicated to this particular topic. In the first study, children with constitutional attention deficit disorder have been compared to children with idiopathic epilepsy and attentional deficits. Structural and/or functional differences between these two groups were looked at in detail. Children of both clinical index groups compared to healthy children were found to have similar structural (MRI and fMRI) and functional (neuropsychology) deficits, so that a common pathophysiological basis of these cognitive problems of these groups could be assumed. The case control study N°2 about children with benign epilepsy with centro-temporal spikes (BECTS) and control children should show the influence of several parameters such as start, duration and degree of severity of epilepsy and the exact localisation of the epileptic focus on language and working memory network and its reorganisation with the help of fMRI, source EEG and neuropsychological testing. Epileptologie 2011; 28: 98 – 106
Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity (2005)

Herein, we report a small molecule MCH-R1 antagonist which demonstrates oral efficacy in chronic rodent models. Substituted phenyl biaryl urea derivatives were synthesized and evaluated as MCH-R1 antagonists for the treatment of obesity. The structure-activity relationship studies in this series resulted in identification of urea 1 as a potent and selective MCH-R1 antagonist. Compound 1 exhibited oral efficacy in chronic (28 d) rodent models at 3-30 mpk showing significant reduction in food intake and weight gain relative to controls.
Bioinformatics Approaches in the Study of Cancer (2007)

A revolution is underway in the approach to studying the genetic basis of cancer. Massive amounts of data are now being generated via high-throughput techniques such as DNA microarray technology and new computational algorithms have been developed to aid in analysis. At the same time, standards-based repositories, including the Stanford Microarray Database and the Gene Expression Omnibus have been developed to store and disseminate the results of microarray experiments. Bioinformatics, the convergence of biology, information science, and computation, has played a key role in these developments. Recently developed techniques include Module Maps, SLAMS (Stepwise Linkage Analysis of Microarray Signatures), and COPA (Cancer Outlier Profile Analysis). What these techniques have in common is the application of novel algorithms to find high-level gene expression patterns across heterogeneous microarray experiments. Large-scale initiatives are underway as well. The Cancer Genome Atlas (TCGA) project is a logical extension of the Human Genome Project and is meant to produce a comprehensive atlas of genetic changes associated with cancer. The Cancer Biomedical Informatics Grid (caBIG), led by the NCI, also represents a colossal initiative involving virtually all aspects of cancer research and may help to transform the way cancer research is conducted and data are shared.
Automated Polyp Detector for CT Colonography: Feasibility Study (2000)

An abdominal computed tomographic scan was modified by inserting 10 simulated colonic polyps with use of methods that closely mimic the attenuation, noise, and polyp-colon wall interface of naturally occurring polyps. A shape-based polyp detector successfully located six of the 10 polyps. When settings that enhanced the edge profile of polyps were chosen, eight of 10 polyps were detected. There were no false-positive detections. Shape analysis is technically feasible and is a promising approach to automated polyp detection.
Criteria and Classification of Obesity in Japan and Asia-Oceania (2005)

Research Articles| December 19 2008 Enteralgie und Kolik II. Das arteriosklerotische Leibweh Subject Area: Gastroenterology Max Buch Max Buch Helsingfors Finnland Search for other works by this author on: This Site PubMed Google Scholar Archiv für Verdauungskrankheiten (2004) 10 (5): 466–507. https://doi.org/10.1159/000188200 Article history Published Online: December 19 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Max Buch; Enteralgie und Kolik II. Das arteriosklerotische Leibweh. Archiv für Verdauungskrankheiten 1 July 2004; 10 (5): 466–507. https://doi.org/10.1159/000188200 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsArchiv für Verdauungskrankheiten Search Advanced Search Article PDF first page preview Close Modal 1904Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Optical transmission of narrowband millimeter-wave signals (1995)

We describe experimentally and theoretically three techniques used to transmit narrowband millimeter-wave (MM-wave) analog signals over optical fiber: 1) narrowband MM-wave optical transmitters based on resonant modulation of monolithic semiconductor lasers, 2) feedforward optical modulation, and 3) a passively mode-locked laser operating in an optoelectronic phase-locked loop. The resonant modulation response at the cavity round-trip frequency is fully characterized for multiple-contact lasers under various bias conditions. Issues such as modulation efficiency, passband bandwidth, noise, and intermodulation distortion are addressed. A system implementation of resonant modulation is presented in which two simultaneous 2.5-Mb/s BPSK channels centered at a subcarrier frequency of 41 GHz is transmitted over 400 m of single-mode fiber. Simple microstrip matching circuits are fabricated at 41 GHz to couple the MM-wave signals into the laser. Resonant modulation of single-contact lasers is also reported. Next, implementation of a tunable MM-wave (30-300 GHz) optical transmitter based on feedforward optical modulation is presented, and the fundamental performance of this technique investigated in terms of noise and dynamic range. Feedforward modulation is used to transmit 300-Mb/s data at 39 GHz over 2.2 km of single-mode fiber. Finally, a passively mode-locked monolithic semiconductor laser operating in an optoelectronic phase-locked loop is implemented as a narrowband MM-wave optical transmitter at 46 GHz. The phase-locked loop bandwidth, MM-wave tracking capability, and fundamental limit to the stability of the MM-wave subcarrier is established. The relative merits of the three techniques are discussed and compared. The MM-wave subcarrier transmission results presented here represent the highest reported to date.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Neural Rule Ensembles: Encoding Sparse Feature Interactions into Neural\n Networks (2020)

Artificial Neural Networks form the basis of very powerful learning methods.\nIt has been observed that a naive application of fully connected neural\nnetworks to data with many irrelevant variables often leads to overfitting. In\nan attempt to circumvent this issue, a prior knowledge pertaining to what\nfeatures are relevant and their possible feature interactions can be encoded\ninto these networks. In this work, we use decision trees to capture such\nrelevant features and their interactions and define a mapping to encode\nextracted relationships into a neural network. This addresses the\ninitialization related concern of fully connected neural networks. At the same\ntime through feature selection it enables learning of compact representations\ncompared to state of the art tree-based approaches. Empirical evaluations and\nsimulation studies show the superiority of such an approach over fully\nconnected neural networks and tree-based approaches\n
Electrochemistry: Ionic Liquid Electroprocessing of Reactive Metals (2003)

The ionic liquids were studied as an alternative medium to recover and refine Al, Mg and Ti. The conductivities of 1-butyl-3-methyIimidozalium chloride (BMIC), and its mixtures with aluminum, magnesium and titanium chlorides were measured. The electrochemical behaviour of aluminum in BMIC-AlCl3 system was studied. The reduction of Al2Cl7- was quasi-reversible. The deposition of aluminum involved instantaneous three-dimensional nucleation. In acidic liquid, there are two stages for the dissolution of Al. Electrorefining and electrowinning of Al were conducted to evaluate the feasibility of using the room temperature liquids to recover Al.
A millimeter-wave kinetic inductance detector camera for long-range imaging through optical obscurants (2020)

Millimeter-wave imaging provides a promising option for long-range target detection through optical obscurants such as fog, which often occur in marine environments. Given this motivation, we are currently developing a 150 GHz polarization-sensitive imager using a relatively new type of superconducting pair-breaking detector, the kinetic inductance detector (KID). This imager will be paired with a 1.5 m telescope to obtain an angular resolution of 0.09&deg; over a 3.5&deg; field of view using 3,840 KIDs. We have fully characterized a prototype KID array, which shows excellent performance with noise strongly limited by the irreducible fluctuations from the ambient temperature background. Full-scale KID arrays are now being fabricated and characterized for a planned demonstration in a maritime environment later this year.
REPAIR OF CORNEAL LACERATIONS AND PERFORATIONS (1988)

Lin, David T. C. MD; Webstar, Robert G. Jr. MD; Abbott, Richard L. MD Author Information
Design of photoresists with reduced environmental impact. II. Water-soluble resists based on photocrosslinking of poly(2-isopropenyl-2-oxazoline) (1999)

The performance of water- and solvent-cast, two-component photoresist films containing poly(2-isopropenyl-2-oxazoline) or poly(2-isopropenyl-2-oxazoline-co-styrene) with a photoacid generator has been investigated. These materials afford negative-tone images after deep-UV exposure and development in a suitable medium (water or toluene). Resist solutions prepared from polymers containing at least 80 mol % 2-isopropenyl-2-oxazoline may be cast from and developed in pure water. Features of higher quality can be obtained when the resist is cast from 2-methoxyethanol, probably because side reactions such as partial hydrolysis of the pendant oxazoline rings in aqueous environments are avoided. It was possible to resolve micrometer scale patterns using ca. 200 mJ/cm2 of irradiation at 254 nm, followed by heating 2 min at 130°C and development in water alone. Image quality and etch resistance were improved using copolymers containing up to 20 mol % of styrene repeat units. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1225–1236, 1999
Explorers, Traders, and Slavers: Forging the Old Spanish Trail, 1678-1850 (1999)

Journal Article Explorers, Traders, and Slavers: Forging the Old Spanish Trail, 1678–1850 Get access Explorers, Traders, and Slavers: Forging the Old Spanish Trail, 1678–1850. By Sánchez Joseph P.. (Salt Lake City: University of Utah Press, 1997. xi + 186 pp. Illustrations, appendixes, notes, bibliography, index. $29.95.) Art Gomez Art Gomez National Park Service, Santa Fe Search for other works by this author on: Oxford Academic Google Scholar Western Historical Quarterly, Volume 30, Issue 1, Spring 1999, Pages 84–85, https://doi.org/10.2307/971179 Published: 01 February 1999
Efficient WDM Laser Sources Towards Terabyte/s Silicon Photonic Interconnects (2013)

Efficient multi-wavelength sources are essential to realize sub-pJ/bit modulated silicon photonic links for multi-TB/s interconnect applications. From a complete link perspective, we discuss the efficiency requirement for silicon WDM on-chip sources. A waveguide-coupled wall-plug efficiency (WPE) better than 10% is important to complement ultra-low power silicon photonic components for practical implementations. We propose a non-invasive hybrid, flip-chip integration approach using surface-normal coupling of an un-cooled III/V gain medium with a tunable wavelength selective silicon reflector. We show that a tunable, external-cavity WDM laser using such a hybrid integration approach can achieve high waveguide-coupled WPE when optimized. A proof-of-concept demonstration achieved a C-band tunable laser with an output power of more than 6 mW in the silicon waveguide, a tuning range of 15 nm, and a WPE of over 4.5%.
Ultrahigh-Q metallic nanocavity resonances with externally-amplified intracavity feedback (2014)

We propose a mechanism of ultrahigh-Q metallic nanocavity resonances that involves an efficient loss-compensation scheme favorable for room-temperature operation. We theoretically show that surface plasmon-polaritons excited on the entrance and exit interfaces of a metallic nanocavity array efficiently transfer external optical gain to the cavity modes by inducing resonantly-amplified intracavity feedback. Surprisingly, the modal gain in the nanocavity with the externally amplified feedback is inversely proportional to the cavity length as opposed to conventional optical cavity amplifiers requiring longer cavities for higher optical gain. Utilizing this effect, we numerically demonstrate room-temperature nanocavity resonance Q-factor exceeding 10(4) in a 25-nm-wide silver nanoslit array. The proposed mechanism provides a highly efficient plasmonic amplification process particularly for subwavelength plasmonic cavities which are essential components in active nanoplasmonic devices.
Characterization of Eu-Doped SnO[sub 2] Thin Films Deposited by Radio-Frequency Sputtering for a Transparent Conductive Phosphor Layer (2006)

Eu-doped thin films deposited by radio-frequency (rf) magnetron sputtering have been studied for the transparent conductive phosphor layer, which is transparent in visible light, electrically conductive, and luminescent. The resistivity of the film increased as the firing temperature and Eu concentration increased. The film showed an excitation peak at 300 nm and an emission peak at 588 nm. The maximum photoluminescence and cathodoluminescence intensity was observed under conditions of 1.0 atom % Eu doping and a 1200°C firing temperature; the resistivity was and the transmittance was above 70%. The relation between the resistivity and cathodoluminescence intensity has been discussed.
Bitter to Better: How to Make Bitcoin a Better Currency (2012)

Abstract. Bitcoin is a distributed digital currency which has attracted a substan-tial number of users. We perform an in-depth investigation to understand what made Bitcoin so successful, while decades of research on cryptographic e-cash has not lead to a large-scale deployment. We ask also how Bitcoin could become a good candidate for a long-lived stable currency. In doing so, we identify several issues and attacks of Bitcoin, and propose suitable techniques to address them. 1