gebhart/patrepeval huggingface dataset:
Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives (2013)

Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity, but they may increase the risk of myocardial infarction with chronic use. The fact that nitroxyl (HNO) reduces platelet aggregation, preconditions against myocardial infarction, and enhances contractility led us to synthesize a diazeniumdiolate-based HNO-releasing aspirin and to compare it to an NO-releasing analogue. Here, the decomposition mechanisms are described for these compounds. In addition to protection against stomach ulceration, these prodrugs exhibited significantly enhanced cytotoxcity compared to either aspirin or the parent diazeniumdiolate toward nonsmall cell lung carcinoma cells (A549), but they were not appreciably toxic toward endothelial cells (HUVECs). The HNO-NSAID prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes compared to control. Together, these anti-inflammatory, antineoplasic, and contractile properties suggest the potential of HNO-NSAIDs in the treatment of inflammation, cancer, or heart failure.
Self-organized antenna array calibration (2011)

The performance of direction finding algorithms is severely degraded by any phase and amplitude error between the adjacent elements of an array antenna. Due to analog hardware behavior these errors are time-varying and depend on temperature, component aging and other component specific characteristics. Therefore, the calibration coefficients have to be updated periodically and adaptively during radar system operation.
Taking the Blame Game out of Data Centers Operations with NetPoirot (2016)

Today, root cause analysis of failures in data centers is mostly done through manual inspection. More often than not, cus- tomers blame the network as the culprit. However, other components of the system might have caused these failures. To troubleshoot, huge volumes of data are collected over the entire data center. Correlating such large volumes of diverse data collected from different vantage points is a daunting task even for the most skilled technicians. In this paper, we revisit the question: how much can you infer about a failure in the data center using TCP statistics collected at one of the endpoints? Using an agent that cap- tures TCP statistics we devised a classification algorithm that identifies the root cause of failure using this information at a single endpoint. Using insights derived from this classi- fication algorithm we identify dominant TCP metrics that indicate where/why problems occur in the network. We val- idate and test these methods using data that we collect over a period of six months in a production data center.
Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma. (1995)

Accumulating evidence implicates the presence of putative tumor suppressor genes on human chromosome 4 that are potentially inactivated in the genesis of several different neoplasms. To accurately determine the frequency of allelic loss on both arms of human chromosome 4, we screened 282 fresh-frozen human bladder carcinomas for allelic loss. Loss of heterozygosity of at least one marker for chromosome 4 was identified in 129 tumors (45.7%). Fine mapping was accomplished using up to 15 polymorphic markers on the p arm and 19 markers on the q arm. We identified a 3-cM minimal area of loss on the p arm between microsatellite markers D4S1608 and D4S404 deleted in 82 tumors (29%). A total of 68 tumors (24%) targeted a 14-cM critical region identified on the distal q arm between markers D4S426 and D4S408. Loss of these two regions correlated with advanced stage and grade of the lesions. These data identify distinct regions of loss on chromosome 4 potentially involved in the late progression of bladder carcinoma.
Vermiculite as an Anti-Sag Additive for Water-Based Drilling Fluids (2022)

Barite is widely used as a weighing material since it has several advantages such as high specific gravity, readily accessible, and environmentally benign. Even though, several difficulties with barite particle settling particularly at high-pressure high-temperature drilling operations and removal efficiency necessitate further investigation. The utilization of magnesium-aluminum-iron silicate (vermiculite) with its ecofriendly effect was studied in this work as an additive for improving the drilling fluid characteristics. Variable concentration of vermiculite was added to the water-based mud (WBM) to address the static and dynamic sag tendencies at 250 and 120 °F, respectively. Furthermore, the influence of vermiculite on rheological characteristics and filtration performance was studied under HPHT circumstances. The sagging experiments showed that adding 4 lb/bbl vermiculite improved the WBM stability properties by increasing the suspension capacity of barite particles. Also, this amount of vermiculite significantly enhanced the rheological characteristics as the plastic viscosity to yield point ratio (YP/PV) was increased from 1.6 to 2.5. The HPHT filtration showed that 4 lb/bbl decreased the filter cake thickness by 37.5% and reduced the filtrated volume by 39%.
THE EQUILIBRATION OF RADIOSODIUM (Na24), RADIOPOTASSIUM (K42), AND DEUTERIUM OXIDE (D2O) IN HYDROPIC HUMAN SUBJECTS 1 (1957)

Isotope dilution methods have been described for the determination of total exchangeable sodium (Nae) (1, 2), total exchangeable potassium (Ke) (3-5), and total body water (T.B.W.) (6-8) with Na24, K42 and D20 as tracers. The time required for equilibrium of distribution of each of the isotopes must be determined experimentally, since uniform mixing is an ex- plicit assumption with these methods (9). In normal human subjects the times required for 95 to 100 per cent equilibration were found to be 12 to 20 hours for Na24, 18 to 40 hours for K42, and 2 to 3 hours for D20 (1-7). The presence of ab- normal fluid collections, however, may produce significant delays in diffusion equilibrium.
Impact of uranium carbide organics treated by prolonged boiling and electrochemical oxidation upon uranium and plutonium solvent extraction (2017)

Abstract The dissolution of uranium or uranium-plutonium carbide fuel in nitric acid leads to ~50% carbon evolved as carbon dioxide, the remainder remains in the solution as soluble organics. These dissolved organic molecules interfere with the solvent extraction of uranium and plutonium by complexing to the actinide ions and decreasing the efficiency of their extraction. Experiments reported here describe two series of experiments assessing the uranium carbide dissolution liquor treatment by prolonged boiling and electrochemical oxidation. Plutonium losses to aqueous and solvent raffinates are observed for untreated liquors, highlighting that mineralisation of dissolved organics is necessary to reduce the complexing effects of organic acids to an extent that permit efficient operation of a solvent extraction process both in the first solvent use (considered here) and for maintaining solvent quality during industrial solvent reuse in the highly active cycle. Solution carbon analysis and 30% TBP solvent extraction batch tests of uranium and plutonium originating from dissolved uranium carbide liquors untreated and after treatment are compared. These experiments demonstrate the reprocessing of uranium carbides by direct dissolution coupled to a mineralisation process, can achieve near quantitative uranium and high plutonium recoveries (99.9%).
Discovery and analysis of tightly knit communities in telecom social networks (2010)

Community identification has been a major research area in social network analysis. One popular type of community is one in which every member of the community knows every other member, which can be viewed as a clique in a graph representing the social network. In this paper, we present a novel highly scalable method for finding large maximal cliques that is validated with experimental results on several real-life social networks. In addition, while the importance of finding tightly knit communities has been widely accepted, the influence of community on the behavior of the individuals belonging to those communities is relatively unexplored. We also attempt to answer various questions in the context of cliques as communities in telecom social networks: how individuals in communities behave, what influence a community has on the behavior of an individual, and whether communities have a characteristic behavior of their own. We also examine whether the behavior of individuals who belong to communities differs from those who do not. We believe that the findings of such a study will reassert the importance of finding communities in telecom social networks and will help telecom operators improve group targeting and customer relationship management.
Selective Enrichment Yields Robust Ethene-Producing Dechlorinating Cultures from Microcosms Stalled at cis-Dichloroethene (2014)

Dehalococcoides mccartyi strains are of particular importance for bioremediation due to their unique capability of transforming perchloroethene (PCE) and trichloroethene (TCE) to non-toxic ethene, through the intermediates cis-dichloroethene (cis-DCE) and vinyl chloride (VC). Despite the widespread environmental distribution of Dehalococcoides, biostimulation sometimes fails to promote dechlorination beyond cis-DCE. In our study, microcosms established with garden soil and mangrove sediment also stalled at cis-DCE, albeit Dehalococcoides mccartyi containing the reductive dehalogenase genes tceA, vcrA and bvcA were detected in the soil/sediment inocula. Reductive dechlorination was not promoted beyond cis-DCE, even after multiple biostimulation events with fermentable substrates and a lengthy incubation. However, transfers from microcosms stalled at cis-DCE yielded dechlorination to ethene with subsequent enrichment cultures containing up to 10(9) Dehalococcoides mccartyi cells mL(-1). Proteobacterial classes which dominated the soil/sediment communities became undetectable in the enrichments, and methanogenic activity drastically decreased after the transfers. We hypothesized that biostimulation of Dehalococcoides in the cis-DCE-stalled microcosms was impeded by other microbes present at higher abundances than Dehalococcoides and utilizing terminal electron acceptors from the soil/sediment, hence, outcompeting Dehalococcoides for H2. In support of this hypothesis, we show that garden soil and mangrove sediment microcosms bioaugmented with their respective cultures containing Dehalococcoides in high abundance were able to compete for H2 for reductive dechlorination from one biostimulation event and produced ethene with no obvious stall. Overall, our results provide an alternate explanation to consolidate conflicting observations on the ubiquity of Dehalococcoides mccartyi and occasional stalling of dechlorination at cis-DCE; thus, bringing a new perspective to better assess biological potential of different environments and to understand microbial interactions governing bioremediation.
On Quantization of Image Classification Neural Networks for Compression Without Retraining (2022)

We studied the quantization of neural networks for their compression and representation without retraining. The goal is to facilitate neural network representation and deployment in standard formats so that general networks may have their weights quantized and entropy coded within the deployment format. We relate weight entropy and model accuracy and try to evaluate distribution of weights against known distributions. Many scalar quantization strategies were tested. We have found that weights are typically approximated by a Laplacian distribution for which optimal quantizers are approximated by entropy-coded uniform quantizers with dead-zones. Results indicate that it is possible to reduce 8-fold the size of the popular image classification networks with accuracy losses near 1%.
Fast synthesis, morphology transformation, structural and optical properties of ZnO nanorods grown by seed-free hydrothermal method (2014)

A fast and low cost seed-free hydrothermal synthesis method to synthesize zinc oxide (ZnO) nanorods with controllable morphology, size and structure has been developed. Ammonia is used to react with water to tailor the ammonium hydroxide concentration, which provides a continuous source of OH− for hydrolysis and precipitation of the final products. Hence, allowing ZnO nanorods to growth on large areas of metal (Au and Ag coated glass), p-type Si and organic flexible (PEDOT: PSS) substrates. Increasing the growth time, the morphology transforms from pencil-like to hexagonal shape rod-like morphology. Within one hour the length of the ZnO nanorods has reached almost 1 µm. The optical characteristics has shown that the grown ZnO nanorods are dominated by two emission peaks, one is in the UV range centered at 381 nm and other one with relatively high intensity appears in the visible range and centered at 630 nm. While the growth duration was increased from 2 h to 6 h, the optical band gap was observed to increase from 2.8 eV to 3.24 eV, respectively. This fast and low cost method is suitable for LEDs, UV-photodetector, sensing, photocatalytic, multifunctional devices and other optoelectronic devices, which can be fabricated on any substrates, including flexible and foldable substrates.
Antigen-Dependent Integration of Opposing Proximal TCR-Signaling Cascades Determines the Functional Fate of T Lymphocytes (2014)

T cell anergy is a key tolerance mechanism to mitigate unwanted T cell activation against self by rendering lymphocytes functionally inactive following Ag encounter. Ag plays an important role in anergy induction where high supraoptimal doses lead to the unresponsive phenotype. How T cells "measure" Ag dose and how this determines functional output to a given antigenic dose remain unclear. Using multiparametric phospho-flow and mass cytometry, we measured the intracellular phosphorylation-dependent signaling events at a single-cell resolution and studied the phosphorylation levels of key proximal human TCR activation- and inhibition-signaling molecules. We show that the intracellular balance and signal integration between these opposing signaling cascades serve as the molecular switch gauging Ag dose. An Ag density of 100 peptide-MHC complexes/cell was found to be the transition point between dominant activation and inhibition cascades, whereas higher Ag doses induced an anergic functional state. Finally, the neutralization of key inhibitory molecules reversed T cell unresponsiveness and enabled maximal T cell functions, even in the presence of very high Ag doses. This mechanism permits T cells to make integrated "measurements" of Ag dose that determine subsequent functional outcomes.
Multiple-equilibria model describing the axial ligand dependence of the dioxygen affinity of an iron(II) lacunar complex. An approach to the regulation of dioxygen affinity (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple-equilibria model describing the axial ligand dependence of the dioxygen affinity of an iron(II) lacunar complex. An approach to the regulation of dioxygen affinityKenneth A. Goldsby, Brian D. Beato, and Daryle H. BuschCite this: Inorg. Chem. 1986, 25, 14, 2342–2347Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ic00234a013https://doi.org/10.1021/ic00234a013research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In situ vibrational spectroscopy of contact adsorbed thiocyanate on silver electrodes: experiment and theory (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ vibrational spectroscopy of contact adsorbed thiocyanate on silver electrodes: experiment and theoryM. G. Samant, K. Kunimatsu, R. Viswanathan, H. Seki, G. Pacchioni, P. S. Bagus, and M. R. PhilpottCite this: Langmuir 1991, 7, 6, 1261–1268Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/la00054a040https://doi.org/10.1021/la00054a040research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Content Delivery Services in a Grid Environment (2011)

n this chapter, we propose a new approach for content delivery services by meshing together the best of grid computing and peer-to-peer (P2P) computing. The goal is to design a secure, reliable, and scalable system for efficient and fast delivery of content. The system consists of a combination of nondedicated servers and peers to provide the proposed service. We describe the challenges of designing such a system and discuss possible solutions and trade-offs. We detail the necessary interlacing of grid and P2P feature to achieve the goal. We present a prototype that is built based on the proposed approach.
Structure and Function in the Isolated Reaction-Center Complex of Photosystem II. 2. Models for Energy Relaxation and Charge Separation in a Protein Matrix (2003)

We have developed a model that describes the energy and charge transfer in photosystem II reaction-center complexes, using parameters with clear physical interpretations. The input parameters are deduced from independent experimental work and from the theoretical constraints of the system. This model is comprised of exitonically coupled chlorophyll electronic states, including charge-transfer states, which are coupled to the protein bath. The dynamics of the system are calculated using a master-equation approach, and the results are converted into spectroscopic observables for comparison with experimental data. The model accurately depicts the emission kinetics observed for both bacterial reaction centers from Rhodobacter sphaeroides and photosystem II from spinach. The model is discussed with regard to the wavelength dependence of energy transfer, the effects of static disorder in the system, and the initial ultrafast dynamics of the charge separation.
Reductive Elimination of Aryl Halides upon Addition of Hindered Alkylphosphines to Dimeric Arylpalladium(II) Halide Complexes (2004)

We report the reductive elimination of haloarene from {Pd[P(o-tol)3](Ar)(μ-X)}2 (X = Cl, Br, I) upon addition of the strongly electron-donating, but sterically hindered, phosphine P(t-Bu)3 and related ligands. Reductive elimination of aryl chlorides, bromides, and iodides from these dimeric arylpalladium(II) halide complexes was observed upon the addition of P(t-Bu)3. Conditions to observe the elimination and addition equilibria were established for all three halides, and values for these equilibrium constants were measured. Reductive elimination of aryl chlorides was most favored thermodynamically, and elimination of aryl iodide was the least favored. However, reactions of the aryl chloride complexes were the slowest. Detailed mechanistic data revealed that cleavage of the starting dimer, accompanied by ligand substitution either before or after cleavage, led to the formation of a three-coordinate arylpalladium(II) halide monomer that reductively eliminated haloarene.
Numerical modeling of textured silicon solar cells using PC-1D (1990)

PC-1D is a quasi-one-dimensional finite-element program for modeling semiconductor devices on personal computers. The program offers solar cell researchers a convenient user interface with the ability to address complex issues associated with heavy doping, high-level injection, nonplanar structures, and transients. The physical and numerical models used in PC-1D Version 2 that make it possible to approximate the multidimensional effects found in textured crystalline silicon solar cells, including the effects of increased front-surface recombination, oblique photon path angles, and light trapping, are presented. As an example of how the model can be applied, PC-1D is used to investigate the interpretation of spectral quantum efficiency data as a tool for diagnosing the internal performance of textured silicon solar cells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
OS2121 Observation rolling contact fatigue crack in high-strength steel using Synchrotron Radiation Laminography (2014)

In rolling contact fatigue (RCF), cracks are usually initiated from inclusions under the surface and propagated to the contact surface. In the present study, RCF cracks was observed using synchrotron radiation computed laminography (SRCL) in SPring-8. For observation of crack propagation, ex situ rolling fatigue test and SRCL were applied to same sample. Laminography is suitable for the observation of sheeted material and sheeted sample is useful for operation of rolling fatigue tests. The specimen with flaking damage was measured by SRCL. It was found that two types of cracks, vertical crack and horizontal crack under the contact surface, which is typically rolling fatigue crack, can be measured by SRCL. For observation of RCF crack propagation, vertical crack which initiate from inclusion and propagated in the direction perpendicular to the contact surface, could be detected. SRCL and fatigue tests were conducted three times. As results, crack propagation could be observed between first and third measurements, while the different part of crack was detected in second measurement. Residual compression stress is considered to affect the observation of RCF crack. SRCL is concluded to be effective for evaluation of initiation and propagation behavior of crack in the rolling fatigue.