gebhart/patrepeval huggingface dataset:
Finite element modeling of human placental tissue. (2009)

Motor vehicle crashes account for a large portion of placental abruption and fetal losses. To better understand the material properties of the human placenta, a Finite Element (FE) model of human placenta tissue was created and verified using data from uniaxial tension tests. Sixty-four tensile tests at three different strain rates of 7% strain/s, 70% strain/s, and 700% strain/s from six whole human placentas were used for model development. Nominal stresses were calculated by dividing forces at the grips by the original cross-sectional area. Nominal strains were calculated by dividing cross-head displacement by the original gauge length. A detailed methodology for interpreting experimental data for application to material model development is presented. A model of the tension coupon was created in LS-DYNA and stretched in the same manner as the uniaxial tension tests. The behavior of the material was optimized to the uniaxial tension test using a multi-island genetic algorithm. The results demonstrate good correlation between experiments and the model, with an average difference of 2% between the optimized FE and experimental first principal stress at the termination state. The material parameters found in this study can be utilized in FE models of placental tissues for behavior under dynamic loading.
Production of gases. [catalytic gasification of light hydrocarbons to produce gas consisting principally of methane and carbon dioxide; catalytic gasification of methanol to methane] (1975)

The invention is generally concerned with a process for the production of gaseous products by a chemical reaction, at least one reactant being liquid at normal temperature and pressure, which process comprises conducting the said reaction at a given pressure or a given temperature in the presence of a proportion of at least one of the reactants in the liquid phase, thereby controlling the temperature or the pressure of the reaction. The process is particularly useful for the catalytic gasification of light hydrocarbons with steam with water being present in the liquid phase, to produce a product gas which consists substantially of methane and carbon dioxide. (Official Gazette)
RT-qPCR-based tests for SARS-CoV-2 detection in pooled saliva samples for massive population screening to monitor epidemics (2022)

Swab, RT-qPCR tests remain the gold standard of diagnostics of SARS-CoV-2 infections. These tests are costly and have limited throughput. We developed a 3-gene, seminested RT-qPCR test with SYBR green-based detection designed to be oversensitive rather than overspecific for high-throughput diagnostics of populations. This two-tier approach depends on decentralized self-collection of saliva samples, pooling, 1<sup>st</sup>-tier testing with highly sensitive screening test and subsequent 2<sup>nd</sup>-tier testing of individual samples from positive pools with the IVD test. The screening test was able to detect five copies of the viral genome in 10 µl of isolated RNA with 50% probability and 18.8 copies with 95% probability and reached Ct values that were highly linearly RNA concentration-dependent. In the side-by-side comparison, the screening test attained slightly better results than the commercially available IVD-certified RT-qPCR diagnostic test DiaPlexQ (100% specificity and 89.8% sensitivity vs. 100% and 73.5%, respectively). Testing of 1475 individual clinical samples pooled in 374 pools of four revealed 0.8% false positive pools and no false negative pools. In weekly prophylactic testing of 113 people within 6 months, a two-tier testing approach enabled the detection of 18 infected individuals, including several asymptomatic individuals, with substantially lower cost than individual RT-PCR testing.
Line-center/Side-line Diode Laser Seeding for DIAL Measurements of the Atmosphere (1995)

The ability of DIAL systems to probe deeply into the atmosphere is enhanced if the pulsed laser is capable of sequentially operating at different wavelengths, each wavelength corresponding to a different absorption cross-section of the gas of interest. Such wavelength versatility is particularly important for airborne or spacebome DIAL measurements of H 2 O(v) due to its strong vertical gradient (several orders of magnitude). Strong H 2 O(v) cross-sections are necessary to retrieve H 2 O(v) data from high altitudes while the use of weaker cross sections enables penetration of the DIAL laser pulses to lower altitudes.
Multi-Core Photonic Crystal Fibers and Their Applications to Fiber Devices (2006)

Photonic crystal fibers (PCFs) have recently attracted considerable attention because of their interesting and unconventional optical properties. Particularly, multi-core photonic crystal fibers (MCPCFs) have several potential advantages making them excellent candidates for applications such as, wavelength multiplexerdemultiplexer (MUX-DEMUX) devices, polarization splitters (PSs), dispersion-compensating fibers (DCFs), curvature sensors, vector bend sensors, Doppler difference velocimeters, phase-locked high-power lasers, optical frequency comb generators, and so on. In this paper MCPCF-structures and some potential applications are reviewed, and in addition design principles for constructing wavelength MUX-DEMUX, PS, DCF based on, two-core, three-core, and dual-concentric-core PCFs respectively, are introduced.
Targeted In Vivo Extracellular Matrix Formation Promotes Neovascularization in a Rodent Model of Myocardial Infarction (2010)

We demonstrated that antibody-targeted ECM-derived peptides alone can be used to sufficiently alter the extracellular matrix microenvironment to induce a dramatic angiogenic response in the myocardial infarct area. Our results indicate a potentially new non-invasive strategy for repairing damaged tissue, as well as a novel tool for investigating in vivo cell biology.
Metaplasticity: Dark exposure boosts excitability and visual plasticity in adult human cortex (2022)

A bstract An interlude of dark exposure for about one week is known to shift the excitatory/inhibitory (E/I) balance of the mammalian visual cortex, promoting cortical plasticity across species and accelerating visual recovery in animals that have experienced cortical lesions during development. However, the translational impact of our understanding of dark exposure from animal studies on humans remains elusive. Here, we use magnetic resonance spectroscopy as a probe for E/I balance in the primary visual cortex (V1) to determine the effect of 60-min dark exposure, and measure binocular combination as a behavioral assay to assess visual plasticity in 18 normally sighted human adults (13 females). To induce neuroplastic changes in the observers, 60-min monocular deprivation was performed, which is known to shift sensory eye balance in favor of the previously deprived eye. We report that prior dark exposure strengthens cortical excitability in V1 and boosts visually plasticity in normal adults. Our findings are surprising, given the fact that the interlude is very brief. We present direct evidence that an environmental manipulation that reduces intracortical inhibition can act as a metaplastic facilitator for visual plasticity in adult humans.
Experience with the merry-go-round test (1990)

Studies of the merry-go-round test (MGR), using a newly built apparatus, and the influence of the test procedure on the performance of different HV polymeric outdoor insulation housing materials are presented. In the test, the surface leakage currents, mass and wettability changes of the studied samples were monitored. The materials investigated were bisphenolic and cycloaliphatic epoxies, HTV and RTV silicone rubbers, and EPDM rubbers. Results show that epoxies containing a silane-treated filler perform very well in the test. The performance of the silicone rubbers, except for preservation of their hydrophobic properties, was comparable to that of the EPDM rubbers. This is contradictory to the materials' field performance and indicates that there are still problems with interpretation of the MGR test results and their correlation with actual service experience.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tunable Design for LTE Mobile-Phones (2014)

Antenna volume has become a critical parameter in mobile phone antenna design, as broader bandwidths are required for high connectivity between users. Shrinking the antenna size affects its efficiency, if one does not sacrifice bandwidth. This paper proposes an architecture to address the need for small and wide-band antennas. The study focuses on the low-frequencies (700 MHz - 960 MHz) in order to address a tough scenario for small platforms. A tunable design of the front-end and the antennas of the mobile phone is proposed and investigated. Operation is achieved on all low-bands with an efficiency of -3 dB at 700 MHz.
Regularity of the SLE$_4$ uniformizing map and the SLE$_8$ trace (2021)

We show that the modulus of continuity of the SLE$_4$ uniformizing map is given by $(\log δ^{-1})^{-1/3+o(1)}$ as $δ\to 0$. As a consequence of our analysis, we show that the Jones-Smirnov condition for conformal removability (with quasihyperbolic geodesics) does not hold for SLE$_4$. We also show that the modulus of continuity for SLE$_8$ with the capacity time parameterization is given by $(\log δ^{-1})^{-1/4+o(1)}$ as $δ\to 0$, proving a conjecture of Alvisio and Lawler.
Syntheses of diazadithiacrown ethers containing two 8-hydroxyquinoline side arms (2001)

Ten new diazadithiacrown ethers containing two 8-hydroxyquinoline (HQ) sidearms attached through the HQ 7-positions and four new diazadithiacrown ethers containing two HQ sidearms attached through the HQ 2-positions have been prepared. Some of these new ligands also contain a hydroxymethyl substituent. The starting macrocyclic diazadithiacrown ethers were obtained by treatment of a bis(-chloroamide) with the appropriate dimercaptan using K 2 CO 3 as the base followed by reduction of the resulting macrocyclic dithiadiamide by BH 3 -THF or by NaBH 4 in the presence of BF 3 -ether as a catalyst. HQ-containing ligands 23-32 were synthesized by a Mannich reaction of the secondary macrocyclic diamines with the substituted-8hydroxyquinoline. HQ-containing ligands 33-36 were prepared by reductive amination of the secondary macrocyclic diamines with 8-hydroxyquinoline-2-carbaldehyde. The HQ-containing diazadithiacrown ethers which also contain a hydroxymethyl group on the macroring 23-29, 33, and 35 are more soluble in polar solvents than those without the hydroxymethyl group.
PELVIC TRAUMA AND IMPAIRED SEXUAL ACTIVITY (2002)

Purpose: Van Den Bosch reported diminished quality of sexual intercourse in 40% of the patients victims of pelvic fractures. Using the Rosen self-administered questionnaire, five aspects of sexual activity were analysed: erectile function and orgasm, sexual desire, satisfaction with sexual intercourse and overall satisfaction. This retrospective series included patients with pelvic ring fractures in 1999. Material and methods: The situation of 46 patients, aged 30 to 70 years was assessed with the International Index of Erectile Function self-administered questionnaire and a questionnaire concerning the patient’s status. The radiographic analysis included the Tyle classification. Associated injury to the membranous urethra were noted. Students t test was used to compare the IIEF scores in the study population and in a control population constituted for validation of the questionnaire. Results: Forty-six patients responded (60.1%). None of the patients complained of disorders before the accident. Thirty-seven patients had sexual activities during the four weeks before responding including 11 (29.7%) with variable degrees of dyserection. Pubic dysfunction was the only factor associated with impaired sexual activity, leading to lower satisfaction and erectile function. There was no relationship between the five IIEF items and age, duration of follow-up, Tyle classification, branch fractures. Discussion: This study is the first using the IIEF score to ascertain the degree of male sexual dysfunction after pelvic fractures. This self-administered questionnaire provides a tool adapted to the patient’s needs. Compared with the control group, we noted a prevalence of erectile dysfunction to the order of 30% with a significant diminution of overall satisfaction (p Conclusion: The IIEF self-administered questionnaire is interesting for young male patients victims of pelvic trauma, particularly in case of pubic dysjunction. Used during rehabilitation, it can identify patients with sexual sequelae (erectile function) in an overall medical and medicolegal management scheme.
1428: Osteogenic Progenitor Cells in the Peyronie's Disease Plaque may be Responsible for Plaque Ossification (2004)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 11, 2004, 8:00 am - 12:00 pm1 Apr 20041428: Osteogenic Progenitor Cells in the Peyronie's Disease Plaque may be Responsible for Plaque Ossification Dolores Verner, Ansha Qian, Thomas R. Magee, Monica G. Ferrini, Jacob Rajfer, and Nestor F. Gonzalez-Cadavid Dolores VernerDolores Verner More articles by this author , Ansha QianAnsha Qian More articles by this author , Thomas R. MageeThomas R. Magee More articles by this author , Monica G. FerriniMonica G. Ferrini More articles by this author , Jacob RajferJacob Rajfer More articles by this author , and Nestor F. Gonzalez-CadavidNestor F. Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38653-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1428: Osteogenic Progenitor Cells in the Peyronie's Disease Plaque may be Responsible for Plaque Ossification." The Journal of Urology, 171(4S), p. 376 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 376 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Dolores Verner More articles by this author Ansha Qian More articles by this author Thomas R. Magee More articles by this author Monica G. Ferrini More articles by this author Jacob Rajfer More articles by this author Nestor F. Gonzalez-Cadavid More articles by this author Expand All Advertisement PDF downloadLoading ...
Sex differences in heart failure (2019)

Heart failure (HF) continues to be a major contributor of morbidity and mortality for men and women alike, yet how the predisposition for, course and management of HF differ between men and women remains underexplored. Sex differences in traditional risk factors as well as sex-specific risk factors influence the prevalence and manifestation of HF in unique ways. The pathophysiology of HF differs between men and women and may explain sex-specific differences in clinical presentation and diagnosis. This in turn, contributes to variation in response to both pharmacologic and device/surgical therapy. This review examines sex-specific differences in HF spanning prevalence, risk factors, pathophysiology, presentation, and therapies with a specific focus on highlighting gaps in knowledge with calls to action for future research efforts.
Importance of the region around lysine 196 for catalytic activity of adenylyl cyclase from Escherichia coli. (1994)

Escherichia coli adenylyl cyclase contains no sequence that corresponds to the previously defined ATP/GTP binding consensus (A,G)XXXXGK(S,T). Using a search for lysine residues located adjacent to glycine residues, three regions that were possible candidates for part of the ATP binding site were identified. These were the residues located at positions 59, 90, and 196. A plasmid vector capable of overexpressing the cya gene under the control of the lambda PL promoter was mutated at these three loci to convert those lysine residues to methionine. Assays for catalytic activity of the mutated hyperexpressed proteins revealed that only the mutation at position 196 led to loss of activity. Photoaffinity labeling experiments using 8-azido-ATP provided evidence that the loss of activity was associated with a loss of the capability of the enzyme to bind ATP. A further series of replacement mutations in the hyperexpression vector was created at position 196. Assays of the adenylyl cyclase activity of the mutated proteins showed that replacement of lysine 196 by arginine led to minimal change in the activity. Replacements by histidine, glutamine, or glutamic acid resulted in approximately 10-20-fold reductions in the activity; replacements by methionine, isoleucine, or aspartic acid resulted in total loss of activity. When the mutated forms of the cya gene were expressed under the control of the cya promoter, the activity of the wild-type protein was higher than that of all the mutants, including the arginine replacement mutant. All of the mutants that retained activity also retained the capability of adenylyl cyclase to be stimulated by either inorganic orthophosphate or GTP. A helical wheel analysis of the region of adenylyl cyclase around lysine 196 revealed a structure compatible with an amphipathic helix with one face enriched with basic amino acid residues. Assays for adenylyl cyclase activity of a series of replacement mutations of residues on the hydrophilic face of the helix (R188I, R192I, G195I) as well as on the hydrophobic face (R197I) indicated that the R188I, G195I, and K196I replacement mutants were inactive, and R192I was approximately 30% as active as the wild-type, while the R197I mutant was equivalent to the wild-type control. A model is suggested for a unique binding motif in E. coli adenylyl cyclase in which there is a repetition of 3 basic residues on one face of a helix where there is an interaction with the three phosphate groups of ATP.
Alkyl Cation (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Investigation of β-BaB2O4 as a Q switch for high power applications (1995)

A beta barium borate (β-BaB2O4 or BBO) crystal has been used to electro-optically Q switch both diode-pumped and lamp-pumped Nd:YLF laser systems, resulting in stable, high average power operation. Piezoelectric ringing was found to have negligible effects on the performance of the BBO Pockels cell at repetition rates up to 6 kHz. The high damage threshold and low insertion loss of BBO permitted operation up to average powers in excess of 6 kW/cm2, which makes a BBO Pockels cell well suited for high power, small mode volume operation, such as in diode-pumped solid state lasers. Based on typical diode-pumped laser parameters, BBO is expected to extend simple compact Q-switched operation of diode-pumped lasers to average powers of 30–100 W.
Silver Oxide Microwires:  Electrodeposition and Observation of Reversible Resistance Modulation upon Exposure to Ammonia Vapor (2005)

Wires composed of AgxO (1 < x < 2) with diameters ranging from 0.7 to 1.1 μm were prepared by electrochemical step edge decoration on highly oriented pyrolytic graphite (HOPG) electrode surfaces. AgxO microwires were obtained by the oxidative electrodeposition of AgxO from a pH = 6 acetate-based plating solution. Step edge selectivity, coupled with the high nucleation density necessary for wire formation, required that the electrodeposition be carried out within a potential window of just 10 mV. The resulting microwires were characterized by scanning electron microscopy and electron diffraction, Raman spectroscopy, and X-ray photoelectron spectroscopy. AgxO microwires were transferred from the HOPG surface to a glass surface, and electrical contacts were applied to ensembles of between 5 and 100 transferred microwires. The resistance of these microwire ensembles increased reversibly by up to 5000% upon exposure to NH3 vapor, whereas an irreversible decrease in the wire resistance was seen upon exposure to the vapors of strong acids. We propose that the mechanism responsible for this resistance modulation is identical to that proposed recently [Murray et al., Anal. Chem. 2005, 77, 5205] to account for resistance modulation by ammonia of electrodeposited silver metal nanowire ensembles.
PD-1 expression on classical monocytes (CM) as an independent predictor of cancer specific survival in clear cell renal carcinoma (ccRCC). (2016)

562 Background: We have previously shown that PD-1 expression in peripheral blood lymphocytes is elevated in RCC patients at diagnosis and decreases subsequent to surgery. We theorize that classical monocyte (CM) inhibition through PD-1 interferes with antigen presentation necessary to stimulate adaptive immune responses, and, thus, preop CM PD-1 expression is prognostic of poor outcomes. Methods: Blood samples were obtained from RCC patients (n = 90) preop and age-matched healthy donors (n = 25). Flow cytometric (FC) data were quantified as mean fluorescence intensity (MFI) or % of cells that express a biomarker. Patients were excluded if they had comorbid CLL, had prior surgeries for RCC, had non-ccRCC histology, or if the FC data was missing. We have defined elevated CM PD-1 expression at the third quartile level of CM PD-1 expression (784 MFI) in the healthy donors. CM PD-1 level was correlated with patient clinico-pathologic data using non-parametric tests. Cancer specific survival (CSS) curves were estimated with Kaplan-Meier methods and a multivariate analysis was performed. Results: The average age of the ccRCC cohort (n = 68) was 60 (range 25-88) years. 35 patients were Fuhrman Grade III/IV high-grade (HG) histology. With median follow-up of 41 months, 10 patients died with ccRCC. No patients with low-grade disease died. Median CM (%) was lower in those who died of disease compare to censored (64% vs 52%, p = 0.029). Patients with CM PD-1 expression &gt; 784 MFI had lower survival compared to patients with CM PD-1 &lt; 784 MFI (p = 0.02). Among HG patients, CSS at 24 months for CM PD-1 MFI &gt; 784 was 62.1% (95% CI 34.2-81.0) vs 93.3% (95% CI 61.3-99.0) for CM PD-1 MFI &lt; 784. On multivariable analysis, controlling for stage related covariates, CM PD-1 MFI &gt; 784 is associated with inferior CSS (hazard ratio = 5.1 [95% CI: 1.1-24.4], p = 0.04) among HG disease patients. Conclusions: In patients with ccRCC, an elevated preoperative CM PD-1 MFI level was associated with lower survival independent of pathological T stage and localized disease status. Preoperative CM PD-1 MFI may be an important biomarker to stratify patients at risk for poor outcome who may benefit from immunotherapy.