gebhart/patrepeval huggingface dataset:
Characterization of MBE-grown Ga1−xAlxAs alloy films by Raman scattering (1999)

Molecular beam epitaxy (MBE)-grown ternary Ga1−xAlxAs films, with Al composition x ranging from 0 to 1 in steps of 0.1, have been studied by Raman scattering at room temperature and at 80 K. The observed broadening and asymmetry of the first-order longitudinal-optical phonon spectra induced by alloy disorder are simulated using the spatial correlation model. The obtained correlation length for GaAs-like and AlAs-like modes are observed to decrease as the reduction of Ga composition 1−x and Al composition x, respectively. It is also shown that the correlation length depends sensitively on the composition. No significant temperature or phonon mode dependence is found. A combination with thermodynamic analysis suggests that the random compositional distribution in alloy seems to be the dominant contribution to this disorder effect. Copyright © 1999 John Wiley & Sons, Ltd.
Dependence of defects induced by excimer laser on intrinsic structural defects in synthetic silica glasses (1991)

Effects of intrinsic defects on defect formation by excimer-laser irradiation were examined in synthetic silica glasses prepared by different methods. In samples containing oxygen-deficient centers (ODC's), laser-induced E' centers were stable at room temperature. In contrast, in samples heat treated in ${\mathrm{H}}_{2}$ atmosphere, in which almost all ODC's changed into Si-H bonds, the induced-E'-center concentration increased by about two orders of magnitude, and the resulting E' centers were unstable, decaying at room temperature. We thus conclude that the formation efficiency of E' centers from Si-H bonds is much higher than that of ODC's and that the induced-E' centers recombine with radiolytic molecular ${\mathrm{H}}_{2}$ to restore Si-H bonds. It is suggested that a trace amount of Si-H bonds plays an essential role in defect creation and annihilation in OH-containing silica glasses.
Common Metadata Header Format for IP/MPLS Networks (2013)

This document defines the common format for the metadata header used
to carry metadata in IPv4, IPv6, and MPLS packets.
Current Challenges with Copper Interconnects (2007)

In the integrated circuit industry, aluminum-based interconnects and oxide interlayer dielectrics have been replaced with copper interconnects in a dual inlaid architecture and with low-K dielectrics. Inlaid Cu lines offer higher conductivity, improved electromigration performance and a reduced cost of manufacturing. In this manuscript, the current challenges with integrating Cu in high-performance integrated circuits are detailed. As technologies scale, the many steps in the integrated process flow cannot be viewed as independent. The interactions between process steps (module interactions) that must be considered will be discussed. The development of a reliable and manufacturable technology requires a fundamental understanding of these interactions. A process-oriented finite element model (FEM) will be presented to capture the effect of individual process steps on the stress evolution during processing. Finally, the future trends for Cu interconnect will be suggested.
Hypomorphic mutations inTRNT1cause retinitis pigmentosa with erythrocytic microcytosis (2015)

Retinitis pigmentosa (RP) is a highly heterogeneous group of disorders characterized by degeneration of the retinal photoreceptor cells and progressive loss of vision. While hundreds of mutations in more than 100 genes have been reported to cause RP, discovering the causative mutations in many patients remains a significant challenge. Exome sequencing in an individual affected with non-syndromic RP revealed two plausibly disease-causing variants in TRNT1, a gene encoding a nucleotidyltransferase critical for tRNA processing. A total of 727 additional unrelated individuals with molecularly uncharacterized RP were completely screened for TRNT1 coding sequence variants, and a second family was identified with two members who exhibited a phenotype that was remarkably similar to the index patient. Inactivating mutations in TRNT1 have been previously shown to cause a severe congenital syndrome of sideroblastic anemia, B-cell immunodeficiency, recurrent fevers and developmental delay (SIFD). Complete blood counts of all three of our patients revealed red blood cell microcytosis and anisocytosis with only mild anemia. Characterization of TRNT1 in patient-derived cell lines revealed reduced but detectable TRNT1 protein, consistent with partial function. Suppression of trnt1 expression in zebrafish recapitulated several features of the human SIFD syndrome, including anemia and sensory organ defects. When levels of trnt1 were titrated, visual dysfunction was found in the absence of other phenotypes. The visual defects in the trnt1-knockdown zebrafish were ameliorated by the addition of exogenous human TRNT1 RNA. Our findings indicate that hypomorphic TRNT1 mutations can cause a recessive disease that is almost entirely limited to the retina.
Advanced error prediction LDPC for high-speed reliable TLC nand-based SSDs (2014)

Highly reliable solid-state drives (SSDs) with triple-level-cell (TLC) NAND flash and Advanced Error-Prediction Low-Density Parity-Check (AEP-LDPC) are proposed. To increase NAND flash's capacity, bits/cell have been doubled and tripled, which causes reliability to drastically degrade due to narrower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> margins. Previously proposed Error-Prediction LDPC (EP-LDPC) error-correcting code (ECC) improved reliability for Multi-Level-Cell (MLC) NAND flash [4]. However, in EP-LDPC program disturb is not modeled, so precision is limited, especially in short data retention <; 2 days. Here, AEP-LDPC is proposed for TLC NAND flash. By considering effects of program disturb, data retention and floating-gate capacitive coupling, the most accurate SSDs can be realized, with high speed read capability. The SSD's data-retention time increases by more than 12 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sup> , decode iterations decrease 57% and acceptable TLC NAND BER increases by more than 2.8 ×.
DOCSIS provisioning of EPON (DPoE): architecture and services (2012)

DOCSIS Provisioning of EPON is rapidly becoming the technology of choice for cable operators looking for a cost-effective way to deploy high-data-rate Metro Ethernet Forum services in FTTx architecture. This unique combination of Ethernet passive optical network for data transport and field-proven DOCSIS provisioning systems opens a new chapter for business services. Support for mobile backhauling, metro Ethernet point-to-point, voice, and data service is available today, with metro Ethernet point-to-multipoint and multipoint-to-multipoint services support expected to be added in the future.
Waveguide combiner technologies enabling small form factor mixed reality headset architectures (2021)

For the past decade, optics and display hardware developments for mixed reality and smart glasses were merely a shot in the dark, providing enough display immersion and visual comfort for developers to build up apps, especially for the enterprise field. Today, as universal use cases for consumer emerge such as co-presence, digital twin and remote conferencing, new optical functionalities are required to enable such experiences. It is not only a race to smaller form factor and light weight devices for large field of view (FOV) and lower power, but the requirements are also on additional display and sensing features specifically tuned to implement such new universal use cases. Broad acceptance of wearable displays especially in the consumer field is contingent on enabling these new display and sensing requirements in small form factors and low power. This talk will focus on waveguide combiner technologies and how these architectures have evolved over the past years to address such new requirements
Digitalized multiparametric analyses of tumor stroma for identification of low perivascular PDGFBR expression and low vessel density as independent prognosis markers for stage IV CRC. (2014)

e14525 Background: Tumor progression and metastasis are regulated by the tumor stroma (TS), suggesting a largely unexplored prognostic significance of its features. The aim of this study was to perform a multi-parametric analysis of colorectal cancer (CRC) stroma to explore digitally quantified TS characteristics Methods: A tissue microarray with 247 primary stage IV CRC tumors from the phase III NORDIC-VII study was used. Tumors samples were subjected to four double-stainings (CD34 and either ASMA, PDGFbR, Desmin or Ki67). Digital images were collected and subjected to image analyses yielding values for 18 different TS characteristics Results: For each case, values were obtained from 18 different TS metrics, related to marker-defined subsets of fibroblasts and pericytes perivascular cells (PC), and to vascular characteristics such as vessel size, total and size-categorized vessel density (VD) and endothelial cell proliferation We identified strong positive correlations between PDGFbR expression in PC and in fibroblast-rich TS compatible with a common cell-of-origin of these cells. PC coverage was not associated with vessel size implying independent control of these aspects of angiogenesis. Desmin status in PC was independent of ASMA- and PDGFbR-status suggesting that desmin marks a distinct set of PC. Concerning prognostic relevance, the two strongest associations were observed for low PC PDGFbR expression (median OS 19.7 mo for low PC PDGFbR (N=81) vs. 28.8 mo for high PV PDGFbR (N=81); HR=1.8; 95% CI 1.2-2.7; log-rank p=0.008) and low total VD (median OS 18.3 mo for low VD (N=123) vs. 27.6 mo for high VD (N=124); HR=1.7; 95% CI 1.2-2.3; log-rank p=0.001). Both markers remained prognostically significant in multivariate analysis including alkaline phosphatase level, WHO performance and BRAF mutation status: HR=1.8; 95%CI 1.1-2.8; p=0.011 and HR=1.8; 95% CI 1.2-2.8; p=0.009 for PC PDGFbR and total VD respectively. Conclusions: A generic procedure for multi-parametricdigitalized TS characterization have been generated and used to uncover independent prognostic significance of primary tumor VD and PC PDGFbR expression in stage IV CRC
A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response (2018)

In colorectal carcinoma patients, distant metastatic disease is present at initial diagnosis in nearly 25% of them. The majority of patients with metastatic colorectal carcinoma have incurable disease; therefore, new therapies are needed. Agents derived from medicinal plants have already demonstrated therapeutic activities in human cancer cells. Antartina is an antitumor agent isolated from <i>Deschampsia antarctica</i> Desv. This study aimed to evaluate the antitumor properties of Antartina in colorectal carcinoma models. We used human and murine colorectal carcinoma cell lines for investigating proliferation, apoptosis, and cell-cycle effects of Antartina therapy <i>in vitro</i> Avatar and immunocompetent colorectal carcinoma animal models were applied for evaluating the effects of Antartina <i>in vivo</i> Immune response against colorectal carcinoma model was investigated using CTL assay, analyzing dendritic cell activation and intratumor T-cell subpopulation, and by tumor rechallenge experiments. Antartina inhibits <i>in vitro</i> human colorectal carcinoma cell proliferation; however, <i>in vivo</i> experiments in Avatar colorectal carcinoma model Antartina display a limited antitumor effect. In an immunocompetent colorectal carcinoma mice model, Antartina potently inhibited tumor growth and liver metastases, leading to complete tumor regressions in >30% of mice and increased animal survival. In addition, Antartina induced a potent specific cytotoxic T-cell response against colorectal carcinoma and a long-lasting antitumor immunity. Interestingly, Antartina increased tumor immunogenicity and stimulated dendritic cell activation. No toxic effects were observed at the doses employed. Our findings showed that Antartina has the ability to induce antitumor immunity against colorectal carcinoma and can be used to develop new tools for the treatment of colorectal carcinoma. <i>Mol Cancer Ther; 17(5); 966-76. ©2018 AACR</i>.
Measurements of NaI:Tl Electron Response using SLYNCI: Comparison of Different Samples (2007)

This paper measures the sample to sample variation in the light yield non-proportionality of NaI:Tl, and so explores whether this is an invariant characteristic of the material or whether it is dependent on the chemical and physical properties of tested sample. In this work we report on the electron response of nine crystals of NaI(Tl), differing in shape, volume, age, manufacturer and quality. The non-proportionality has been measured at the SLYNCI facility in the energy range between 3.5 to 460 keV. The Scintillation Light Yield Non-proportionality Characterization Instrument (SLYNCI) is a next generation Compton Coincidence device, explicitly designed to study the 'non-proportionality' of the electron response in scintillators and the contribution of this effect to the intrinsic energy resolution. We also discuss the gamma response, x-ray excited emission spectra and decay times for the nine crystals, in order to provide a complete characterization of their physical properties and determine whether the mechanism of scintillation varies between samples.
Modeling Software Evolution using Algebraic Graph Rewriting (2006)

Abstract. We show how evolution requests can be formalized using algebraic graph rewriting. In particular, we present a way to convert the UML class diagrams to colored graphs. Since changes in software may effect the relation between the methods of classes, our colored graph representation also employs the relations in UML interaction diagrams. Then, we provide a set of algebraic graph rewrite rules that formalizes the changes that may be caused by an evolution request, using the pushout
A New Adaptive Readout System For a New OLED OPD Flexible Patch PPG Sensor (2019)

This study proposes a new multiwavelength OLED-OPD flexible PPG sensor with a time-interleaved, optimal high order adaptive analog filter-based readout system for the longtime continuous monitoring of PPG signal. First time, temperature modulation of the light absorption and scattering coefficient of the human skin and its compensation strategy has been explored in this study. This study intended to minimize the issue like motion artifacts and mispositioning. Analog front end of the readout circuit incorporates a transimpedance amplifier, optimal filter, programmable gain amplifier (1x to 7x), PWM-DAC based OLED intensity control, Bluetooth transceiver, MCU with inbuilt ADC and a power management unit. At the backend, digital control and pre-signal processing-algorithm are developed to improve the adaptability of the readout system against nonidealities which enable the readout system for the longtime continuous measurement of the biological sign. Digitally variable resistance is used herein to tune the central frequency of the bandpass filter which helps to minimize low heart rate issue. The sensing range of the readout circuit is 20nA to 10μA. With 3.3 V power supply the total power consumption of the readout system is 0.4W. Experimental result shows that the heart rate measurement error is less than 3.4bpm. In the worst case, the measured repulsive pulse transit time (RPTT) variation from PPG cycle to cycle is less than 2%.
Credibilist simultaneous Localization And Mapping with a LIDAR (2014)

From the early beginning, the Simultaneous Localization And Mapping (SLAM) problem has been approached using a probabilistic background. A new solution based on the Transferable Belief Model (TBM) framework is proposed in this article. It appears that this representation of knowledge affords numerous advantages over the classic probabilistic ones and leads to particularly good performances (an average of 3.2% translation drift and 0.0040deg/m rotation drift), especially when it comes to crowded environment. By introducing the basic concepts of a Credibilist SLAM, this article aims at proving that the use of this new theoretical context opens a lot of perspectives for the SLAM community.
Low Temperature Concentration of Skim Milk by Direct Freezing and Vacuum Evaporation (1995)

Skim milk was concentrated to approximately 20% TS by direct freezing and ice filtration. The concentrate was vacuum evaporated to 45% TS with the same equipment. Protein denaturation was minimal during concentration. Surface tension of milk samples was measured during concentration close to Oe.
Serum microRNA-based prediction of responsiveness to eribulin in metastatic breast cancer (2019)

The identification of biomarkers for predicting the responsiveness to eribulin in patients with metastatic breast cancer pretreated with an anthracycline and a taxane remains an unmet need. Here, we established a serum microRNA (miRNA)-based prediction model for the emergence of new distant metastases after eribulin treatment. Serum samples were collected from metastatic breast cancer patients prior to eribulin treatment and comprehensively evaluated by miRNA microarray. The prediction model for estimating eribulin efficacy was established using the logistic LASSO regression model. Serum samples were collected from 147 patients, of which 52 developed at least one new distant metastasis after eribulin monotherapy and 95 did not develop new distant metastases. A combination of eight serum miRNAs (miR-4483, miR-8089, miR-4755-3p, miR-296-3p, miR-575, miR-4710, miR-5698 and miR-3160-5p) predicted the appearance of new distant metastases with an area under the curve of 0.79, sensitivity of 0.69 and specificity of 0.82. The serum levels of miR-8089 and miR-5698 were significantly associated with overall survival after the initiation of eribulin treatment. The present study provides evidence that serum miRNA profiling may serve as a biomarker for the responsiveness to eribulin and for predicting the development of new distant metastases in metastatic breast cancer.
EVM-Constrained OFDM Precoding for Reduction of Out-of-Band Emission (2009)

This contribution addresses the potential of N-continuous OFDM signals in systems where the receiver is unaware of the transmitter precoder operation. First, we present a memoryless precoder rendering N-continuous signals. Second, we evaluate the effect on the magnitude of the emitted signal's error-vector. Third, we present three ad hoc precoders designed under a hard constraint on the allowed EVM still significantly suppressing out-of-band power.
13PHD1 deficiency promotes an atheroprotective metabolic phenotype (2014)

Knockout of the oxygen-sensor HIF prolyl hydroxylase 1 (PHD1) was shown to switch metabolism towards glycolysis and reduced cellular oxygen consumption. As we recently showed a pro-atherosclerotic effect of plaque hypoxia, we hypothesised that reduced cellular oxygen consumption in PHD1 knockout mice alleviates atherosclerosis development.
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development (2018)

Smad ubiquitin regulatory factor 1 (SMURF1) is a HECT-type E3 ubiquitin ligase that plays a critical role in vertebrate development by regulating planar cell polarity (PCP) signaling and convergent extension (CE). Here we show that SMURF1 is involved in mammalian heart development. We find that SMURF1 is highly expressed in outflow tract cushion mesenchyme and Smurf1<sup>-/-</sup> mouse embryos show delayed outflow tract septation. SMURF1 is expressed in smooth muscle cells of the coronary arteries and great vessels. Thickness of the aortic smooth muscle cell layer is reduced in Smurf1<sup>-/-</sup> mouse embryos. We show that SMURF1 is a negative regulator of cardiomyogenesis and a positive regulator of smooth muscle cell and cardiac fibroblast differentiation, indicating that SMURF1 is important for cell-type specification during heart development. Finally, we provide evidence that SMURF1 localizes at the primary cilium where it may regulate bone morphogenetic protein (BMP) signaling, which controls the initial phase of cardiomyocyte differentiation. In summary, our results demonstrate that SMURF1 is a critical regulator of outflow tract septation and cell-type specification during heart development, and that these effects may in part be mediated via control of cilium-associated BMP signaling.
A prognostic hypoxia gene signature is associated with a dampened tumour immune microenvironment in cervical cancer (2023)

Background: Hypoxia, or low oxygen, is a condition that is characteristic of solid tumours, including cervical cancer. Hypoxia is associated with worse survival in this disease and supports tumorigenic characteristics of stemness, survival, metastasis and angiogenesis, as well as immune resistance. Aims: In this work, we aimed to determine the prognostic significance of a previously derived in vitro eight-gene hypoxia signature in cervical cancer, and to investigate the interplay between the hypoxic and immune features of the cervical tumour microenvironment (TME). Subjects and Methods: The 240 patients with cervical squamous cell carcinoma obtained from the Cancer Genome Atlas Pan-Cancer study were first given a hypoxia score and an immune score (IS) and subsequently subjected to survival analysis. CIBERSORTx was also applied to determine the fractions of immune cells residing in the hypoxia high versus hypoxia low patient groups. Results: We show that the eight-gene hypoxia signature is predictive of worse prognosis in patients with cervical cancer and is associated with a less immunogenic TME. Furthermore, by combining the hypoxia score with an IS to stratify patients based on both their hypoxic and immune status, we achieve an enhancement in survival prediction, with the hypoxia high/immune low subgroup of patients showing the worse probability of overall and disease-specific survival. Conclusions: It is clear from this work that the interplay between the hypoxic and immune microenvironment can contribute to cervical cancer patients' survival. Furthermore, patients with tumours that are both highly hypoxic and immune deprived should be considered for hypoxia-targeted therapy when planning treatment modalities to improve survival.
Electrophoretic Deposition for Cholesteric Liquid‐Crystalline Devices with Memory and Modulation of Reflection Colors (2016)

The first design strategy that allows both memorization and modulation of the liquid-crystalline reflection color is reported. Electrophoretic deposition of a tailored ionic chiral dopant is key to realizing this unprecedented function, which may pave the way for the development of full-color e-paper that can operate without the need of color filters.