gebhart/patrepeval huggingface dataset:
Humidity Effects onDielectric Strength ofAir-Gaps forIndoor HV Installations (2005)

Forindoor HV installations, theelectrode configurations ofair-gaps aredifferent fromoutdoor HV apparatus andthefields areusually optimized. The humidity canbelower andthetemperature isoften higher thantheoutdoor atmosphere. Inorder tostudy theeffect ofhumidity onthebreakdown voltage ofthe indoor air-gaps, laboratory tests wereperformed onthe typical indoor airgaps- toriod/plane aswellas reference gaps-rod/plane andsphere/plane under typical indoor atmosphere conditions. Thetest results indicate that forthereference air-gaps, thecorrection procedure recommended byIEC60060-1 isvalid, while there isanover-correction of6-9%forthetoroid/plane air gaps, which iscaused byhumidity correction.
ChemInform Abstract: CHEMICAL PROPERTIES OF THE FULVENE RADICAL CATION: A CYCLOADDITION WITH 1,3‐BUTADIENE (1980)

Abstract Mittels Cyclotron‐Resonanz‐Spektroskopie wurden die Ion‐Molekül‐Reaktionen des Ions mit Benzol, Prl, Alkenen, MeOCH=CH2 oder 1,3‐Butadien untersucht.
Magnetic Microsphere Scaffold‐Based Soft Microbots for Targeted Mesenchymal Stem Cell Delivery (Small 32/2023) (2023)

Targeted Mesenchymal Stem Cell Delivery Soft microbots assembled from individual magnetic microsphere scaffold (MMS) beads carrying mesenchymal stem cells (MSCs) use an oscillating magnetic field to induce mechanical flexion to propel the microbot to the target location to release their MSC cargo to promote the wound healing process. More details can be found in article number 2300430 by King Lun Yeung and co-workers.
ChemInform Abstract: Synthesis of Pyridine‐Containing Macrocycles by Cobalt‐Mediated Trimerization of Triply‐Bonded Species. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity (2020)

Abstract Chimeric antigen receptor (CAR) T cell therapy has led to impressive clinical responses in patients with hematological malignancies; however, its utility in patients with solid tumors has been limited. While CAR T cells for the treatment of advanced prostate cancer are being clinically evaluated and are anticipated to show bioactivity, their safety and the impact of the immunosuppressive tumor microenvironment (TME) have not been faithfully explored preclinically. Using a novel human prostate stem cell antigen knock-in (hPSCA-KI) immunocompetent mouse model and syngeneic murine PSCA CAR T cells, we performed analyses of normal and tumor tissues by flow cytometry, immunohistochemistry, and/or RNA sequencing. We further assessed the beneficial impact of cyclophosphamide (Cy) pre-conditioning on modifications to the immunosuppressive TME and impact on PSCA-CAR T cell safety and efficacy. We observed an in vivo requirement of Cy pre-conditioning in uncovering the efficacy of PSCA-CAR T cells in prostate and pancreas cancer models, with no observed toxicities in normal tissues with endogenous PSCA expression. This combination also dampened the immunosuppressive TME, generated pro-inflammatory myeloid and T cell signatures in tumors, and enhanced the recruitment of antigen-presenting cells, and endogenous as well as adoptively-transferred CAR T cells, resulting in long-term anti-tumor immunity.
Members of the Tristetraprolin Family of Tandem CCCH Zinc Finger Proteins Exhibit CRM1-dependent Nucleocytoplasmic Shuttling (2002)

Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to certain types of AU-rich elements (AREs) in mRNA. Experiments in TTP-deficient mice have shown that TTP is involved in the physiological destabilization of at least two cytokine mRNAs, those encoding tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor. The two other known mammalian members of the TTP family, CMG1 and TIS11D, also contain ARE-binding CCCH tandem zinc finger domains and can also destabilize ARE-containing mRNAs. To investigate the effects of primary sequence on the subcellular localization of these proteins, we constructed green fluorescent protein fusions with TTP, CMG1, and TIS11D; these were predominantly cytoplasmic when expressed in 293 or HeLa cells. Deletion and mutation analyses revealed functional nuclear export signals in the amino terminus of TTP and in the carboxyl termini of CMG1 and TIS11D. This type of leucine-rich nuclear export signal interacts with the nuclear export receptor CRM1; abrogation of CRM1 activity resulted in nuclear accumulation of TTP, CMG1, and TIS11D. These proteins are thus nucleocytoplasmic shuttling proteins and rely on CRM1 for their export from the nucleus. Although TTP, CMG1, and TIS11D lack known nuclear import sequences, mapping experiments revealed that their nuclear accumulation required an intact tandem zinc finger domain but did not require RNA binding ability. These findings suggest possible roles for nuclear import and export in the regulation of cellular TTP, CMG1, and TIS11D activity.
YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells (2016)

A small population of cancer cells called cancer-initiating cells or cancer stem cells (CSCs) are involved in drug resistance, metastasis, and cancer relapse. Finding pathways that regulate CSC is very important for clinical therapy. ATP-binding cassette sub-family G member 2 (ABCG2) plays a role in side population (SP) cell formation and contributes to chemotherapy resistance in common forms of cancer. Yes-associated protein 1 (YAP1) is a major transcriptional effector of the Hippo pathway, which plays important roles in organ size control and tumorigenesis. In this study, we found ABCG2 and YAP1 were both overexpressed in lung cancer SP cells. Disruption of YAP1 expression by siRNA attenuated the expression of ABCG2 transcript and significantly reduced the percentage of SP cells and sphere formation in lung cancer cells. Overexpression of YAP1 in lung cancers led to an increase in ABCG2 expression and increased the percentage of SP cells. However, overexpression of YAP1 in purified non-SP cells did not increase ABCG2 expression and the percentage of SP cells, which may be due to the inhibition of YAP activity through phosphorylation. YAP1 directly transcriptionally regulated ABCG2 by binding to the promoter of ABCG2. Moreover, the YAP1 inhibitor verteporfin and YAP1 siRNA downregulated ABCG2 level through inhibition of YAP1 in lung cancer cells and sensitized them to the chemotherapy drug doxorubicin. Our study adds a new function for YAP1 that may be relevant to drug resistance and cancer therapy through regulation of ABCG2 and side population cell formation in lung cancer.
Quantum Multiparameter Estimation Model of Cascaded Phases in Optical Fiber (2023)

We present a new architecture for quantum-enhanced multiparameter estimation, where measured phases are cascaded along a single optical fiber. Embedded reflectors separate these phases, enabling novel fiber-based quantum distributed sensing of temperature and strain.
Study of Singlet and Triplet 2,6-Difluorophenylnitrene by Time-Resolved Infrared Spectroscopy (2005)

The solution-phase photochemistry of 2,6-difluorophenyl azide was studied by time-resolved infrared (TRIR) spectroscopy. A vibrational band of singlet 2,6-difluorophenyl nitrene (1N) was observed at 1404 cm(-1) between 243 and 283 K. At ambient temperature, it was not possible to detect this intermediate. At 298 K, only the decay products of the singlet nitrene, the isomerized products ketenimine (K) and triplet-2,6-difluorophenyl nitrene (3N), were observed at 1576 and 1444 cm(-1), respectively. The assignments are consistent with density functional theory calculations and previous studies of this system by laser flash photolysis techniques with UV-visible detection.
Development and validation of an immuno-PET tracer for patient stratification and therapy monitoring of antibody-drug conjugate therapy. (2013)

11006 Background: SAR566658 is an antibody-drug immunoconjugate consisting of a humanized monoclonal antibody (huDS6) against the tumor-associated MUC1-sialoglycotope, CA6, conjugated to a cytotoxic maytansinoid (DM4). SAR566658 is currently undergoing phase I clinical trials in patients with CA6-positive solid tumors. A companion diagnostic based on huDS6 may facilitate patient stratification and early evaluation of therapeutic efficacy. The present study describes the development and preclinical evaluation of three novel Copper-64 (t ½ = 12.7h) labeled antibody fragments (two Fabs and a diabody) derived from the huDS6 antibody. One fragment was chosen based on imaging figures of merit for further specificity evaluations. Methods: The affinity of all fragments and their DOTA conjugates to CA6 was validated using flow cytometry. The DOTA conjugates were labeled with Copper-64 and evaluated in human serum stability studies, in vivo small animal PET imaging and 24-hour biodistribution studies in nude mice bearing either CA6 positive (WISH) or CA6 negative (A2780) subcutaneous tumors. The specificity of the lead tracer was evaluated in vivo via blocking studies and isotype controls. Results: All fragments and their DOTA conjugates had high affinity (K d = 4-20 nM) for WISH cells. 64 Cu-DOTA-B-Fab gave superior results in radio-synthesis (RCY - 60%, SA - 55 GBq/µmole, &gt;99% purity), serum stability (94±5%, n=3) and biodistribution profile. Its two isotype controls gave statistically significant (P&lt;0.05) uptake values in WISH but not A2780 tumors (see table). Blocking with B-Fab or huDS6 prior to tracer administration afforded a 23% (p&lt;0.05, n=8) and 26% (p&lt;0.05, n=7) decrease in WISH tumor uptake, respectively. Conclusions: These preclinical studies suggest that 64 Cu-DOTA-B-Fab may be a suitable companion diagnostic for SAR566658 in cancer patients and requires further investigation.[Table: see text]
ChemInform Abstract: The Highly Enantioselective Transformation of Silylketenes into α‐Silylthioesters Catalyzed by Cinchona Alkaloids. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermographic inspection of pipes, tanks, and containment liners (2015)

Nuclear power plants are required to operate at a high level of safety. Recent industry and license renewal commitments aim to further increase safety by requiring the inspection of components that have not traditionally undergone detailed inspected in the past, such as tanks and liners. NEI 09-14 requires the inspection of buried pipes and tanks while containment liner inspections are required as a part of license renewal commitments. Containment liner inspections must inspect the carbon steel liner for defects - such as corrosion - that could threaten the pressure boundary and ideally, should be able to inspect the surrounding concrete for foreign material that could be in contact with the steel liner and potentially initiate corrosion. Such an inspection requires a simultaneous evaluation of two materials with very different material properties. Rapid, yet detailed, inspection results are required due to the massive size of the tanks and containment liners to be inspected. For this reason, thermal NDE methods were evaluated to inspect tank and containment liner mockups with simulated defects. Thermographic Signal Reconstruction (TSR) was utilized to enhance the images and provide detailed information on the sizes and shapes of the observed defects. The results show that thermographic inspection is highly sensitive to the defects of interest and is capable of rapidly inspecting large areas.
An Ensemble Learning-Based No Reference Qoe Model For User Generated Contents (2021)

The explosive growth of user-generated content (UGC) videos demands new Quality of Experience model for this new type of content. In this paper, we propose a novel No Reference QoE model for UGC videos. The proposed model takes into account not only bitstream-level and packet-level information, but also encoding parameters. Features are extracted from input videos at frame level, then combined by a pooling layer. In addition, ensemble learning is utilized to improve overall prediction performance. Experimental results show that our model can predict MOS values of UGC videos with very high accuracy. Also, the proposed model is simple, and so can be used for real-time QoE monitoring.
Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets (2003)

Arterial occlusive disorders are a leading cause of human morbidity. We hypothesized that ectopic expression of fibrinolytic proteins in platelets could be used to favorably alter the hemostatic balance at sites of thrombosis. To test our hypothesis, we directed murine urokinase-type plasminogen activator transgene expression to platelets using a platelet factor 4 promoter. Urokinase was selectively expressed and stored in the platelets of these mice. These transgenic mice had altered platelet biology and a bleeding diathesis similar to that seen in patients with Quebec platelet disorder, affirming the role of ectopic urokinase expression as the etiology of this inherited disease. These mice were resistant to the development of occlusive carotid artery thrombosis in the absence of systemic fibrinolysis and displayed rapid resolution of pulmonary emboli. Moreover, transfusion of urokinase-expressing platelets into wild-type mice prevented formation of occlusive arterial thrombi. These studies show the feasibility of delivering fibrinolytic agents to sites of incipient thrombus formation through selective storage in platelets and offer a new strategy to prevent thrombosis and hemorrhage.
THE EFFECTS OF ACUPUNCTURE ON CARDIAC MUSCLE CELLS AND BLOOD PRESSURE IN SPONTANEOUS HYPERTENSIVE RATS (2004)

If acupuncture is able to prevent hypertrophy of the heart, it could therefore prevent the heart from overloading and thus prevent heart failure or sudden death. We therefore studied the effects of acupuncture on blood pressure and cardiac muscle cells. Rats with spontaneous hypertension were divided into three acupuncture treatment groups and one non-treatment group. The treatment groups were classified as sham acupoint, Yanglingquan (GB. 34) and Quchi (LI. 11) groups. The measurements recorded included changes in tail pressure, femoral arterial pressure, left ventricular weight (LVW), whole heart weight (WHW), body weight (BW), LVW/BW and WHW/BW ratios and the size of the cardiac muscle cells. The results showed that femoral arterial pressure of subjects which were needled on the selected points for 3 days dropped. Acupuncture at these two acupoints seemed to improve the condition of hypertension in a short period of time. Significant changes in the femoral arterial pressure were observed in all subjects when they were treated for 6 days. In the two acupoint groups, the LVW/BW and the WHW/BW ratios did not change significantly. Cardiac muscle cells reduced in size in the Yanglingquan (GB. 34) treatment groups. This indicates that the Yanglingquan (GB. 34) points not only can lower blood pressure, but also prevent hypertrophy of cardiac muscle cells in spontaneous hypertensive rats (SHR). Therefore, acupuncture could be a good treatment modality for hypertension and hypertrophy of the heart.
Mechanical Energy Harvesting (2012)

This chapter contains sections titled: Energy-harvesting analysis Main sources and conversion principles of mechanical energy Harvesting mechanical energy from vibrations Mechanical energy harvesting from forces/deformations Conclusions and perspectives on mechanical energy harvesting Bibliography
Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope (2014)

Imaging of the retinal vascular structure and perfusion was explored by confocal illumination and nonconfocal detection in an adaptive optics scanning light ophthalmoscope (AOSLO), as an extension of the work by Chui et al. [Biomed. Opt. Express 3, 2537 (2012)]. Five different detection schemes were evaluated at multiple retinal locations: circular mask, annular mask, circular mask with filament, knife-edge, and split-detector. Given the superior image contrast in the reflectance and perfusion maps, the split-detection method was further tested using pupil apodization, polarized detection, and four different wavelengths. None of these variations provided noticeable contrast improvement. The noninvasive visualization of capillary flow and structure provided by AOSLO split-detection shows great promise for studying ocular and systemic conditions that affect the retinal vasculature.
Progress toward a Single-Chip Radio (2017)

The vision for a single-chip radio has been in existence for many years. There also have been numerous claims of single-chip radios. A single-chip radio is an integrated circuit (IC) that can accomplish transmit and receive functions without any off-chip components. An on-chip antenna is a key component of a single-chip radio. Use of on-chip antennas eliminates the need for high-frequency wired input/output, thus avoiding the losses of radio frequency (RF) chip-to-PC-board and transmission line connections. The antenna is fabricated using a metallization scheme commonly used in silicon IC processes and is separated from the silicon substrate by a SiO2 layer. One of the main challenges in designing a single-chip radio is the integration of a high-stability frequency reference. Large signals from an on-chip power amplifier and a transmit antenna could couple to other sensitive RF circuits, such as low-noise amplifier and voltage controlled oscillator, and disrupt their operation.
<title>Schack-Hartmann wavefront sensing measurements of near-ground propagated laser beams</title> (1997)

Adaptive optics systems could be used to maintain the quality of a communication laser beam propagated near ground over a few kilometers of turbulent atmosphere. Such an adaptive optics system may incorporate a Shack- Hartmann sensor to measure the wavefront of an arriving beacon laser beam before precompensating that of the communication laser beam through a deformable mirror. We present experimental measurements of the wavefront of a laser beam propagated over distances of 0.94 and 2.4 km acquired using a 1200-subaperture Shack-Hartmann sensor. These data were acquired at 1 kllz frame rate during 2 second time intervals over the span of several days. We acquired and analyzed 41 sets of data. Our analysis shows that the atmosphere is not stationary over these 2second intervals, that the statistics of the wavefront may look very different for the same measured value of the atmosphere structure constant (C) and does not always follow the theoretical predictions based on Kolmogorov turbulence, and that the subtraction of the first 11 Zernike polynomials (first-order correction) improves the wavefront significantly unlike the subtraction of next 1 1 polynomials (third-order correction).
Minimization of energy consumption in passive HF contactless and RFID systems (2011)

International audience
Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium (2008)

Digital holographic microscopy (DHM) allows optical-path-difference (OPD) measurements with nanometric accuracy. OPD induced by transparent cells depends on both the refractive index (RI) of cells and their morphology. This Letter presents a dual-wavelength DHM that allows us to separately measure both the RI and the cellular thickness by exploiting an enhanced dispersion of the perfusion medium achieved by the utilization of an extracellular dye. The two wavelengths are chosen in the vicinity of the absorption peak of the dye, where the absorption is accompanied by a significant variation of the RI as a function of the wavelength.
Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21 (2007)

Dendritic cells (DCs) are the most potent antigen-presenting cells, yet little data are available on the differential characteristics of donor and recipient DCs (dDCs and rDCs, respectively) during the process of islet allograft rejection. DTR-GFP-DC mice provide a novel tool to monitor DC trafficking and characteristics during allograft rejection. We show rapid migration of dDCs to recipient lymphoid tissues as early as 3 h post-islet allotransplantation. Compared with rDCs, dDCs express different patterns of chemokine receptors, display differential proliferative capacity, and exhibit a higher level of maturity; these findings could be attributed to the effects of injury that dDCs undergo during islet cell preparation and engraftment. Intriguingly, we detected dDCs in the spleen of recipients long after rejection of islet allografts. Given that dDCs express high levels of CCR7, islets were cultured before transplant with the ligand for CCR7 (CCL21). This novel method, which enabled us to enhance the efflux of dDCs from islet preparations, resulted in a prolongation of islet allograft survival in immunocompetent recipients. This study introduces dDCs and rDCs as two distinct types of DCs and provides novel data with clinical implications to use chemokine-based DC-depleting strategies to prolong islet allograft survival.
Simulation of the Adsorption of Nucleotide Monophosphates on Carbon Nanotubes in Aqueous Solution (2008)

We use atomistic molecular dynamics simulations to calculate the binding energy of six different nucleotide monophosphates (NMPs) to a (6,0) single-wall carbon nanotube in aqueous solution. We examine two different aqueous environments, one with just two sodium counterions and a second consisting of approximately 134 mM sodium chloride solution. We find that the binding energies are generally favorable, of the order of a few kilocalories/mole. The binding energies of the different NMPs were very similar in salt solution, whereas we found a range of binding energies for NMPs in pure water. The binding energies are sensitive to the details of the association of the sodium ions with the phosphate groups and also to the average conformations of the nucleotides.
Analog signal transmission by FPGA-based pseudo-delta-sigma modulator (2015)

We present a pseudo-delta-sigma modulator and demonstrate transmission using an advanced modulation. This digitally implemented transmitter helps in reducing the complexity at the receiver and realizing waveform transport over a digital optical network.