gebhart/patrepeval huggingface dataset:
Fault-tolerant real-time analytics with distributed Oracle Database In-memory (2016)

Modern data management systems are required to address new breeds of OLTAP applications. These applications demand real time analytical insights over massive data volumes not only on dedicated data warehouses but also on live mainstream production environments where data gets continuously ingested and modified. Oracle introduced the Database In-memory Option (DBIM) in 2014 as a unique dual row and column format architecture aimed to address the emerging space of mixed OLTAP applications along with traditional OLAP workloads. The architecture allows both the row format and the column format to be maintained simultaneously with strict transactional consistency. While the row format is persisted in underlying storage, the column format is maintained purely in-memory without incurring additional logging overheads in OLTP. Maintenance of columnar data purely in memory creates the need for distributed data management architectures. Performance of analytics incurs severe regressions in single server architectures during server failures as it takes non-trivial time to recover and rebuild terabytes of in-memory columnar format. A distributed and distribution aware architecture therefore becomes necessary to provide real time high availability of the columnar format for glitch-free in-memory analytic query execution across server failures and additions, besides providing scale out of capacity and compute to address real time throughput requirements over large volumes of in-memory data. In this paper, we will present the high availability aspects of the distributed architecture of Oracle DBIM that includes extremely scaled out application transparent column format duplication mechanism, distributed query execution on duplicated in-memory columnar format, and several scenarios of fault tolerant analytic query execution across the in-memory column format at various stages of redistribution of columnar data during cluster topology changes.
ChemInform Abstract: First Synthesis of Symmetrical and Non‐Symmetrical Aza Indolocarbazoles Derivatives. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 5201: PSMA-targeted alpha radioimmunotherapy for prostate cancer with 225Ac-J591 (2017)

Abstract Background: Prostate cancer (PC) is a radiosensitive disease. In addition to external beam and brachytherapy, systemic bone-seeking radioisotopes have been utilized clinically for many years, with radium-223 leading to overall survival benefits. However, the available beta and alpha emitting particles in the clinic target tumors / stroma in bone only. Biologically targeted radiopharmaceutical treatment has shown promising results in our earlier multiple clinical trials using beta-emitting anti-PSMA therapy with Leutetium-177 radiolabeled anti-PSMA monoclonal antibody (mAb) J591, with accurate targeting and tumor response, but treatment is limited by myelosuppression. Both beta and alpha-small molecule PSMA ligand directed therapy has been utilized anecdotally outside of the US, but has not been systemically studied. Based upon their biodistribution, targeting of salivary glands and potentially proximal renal tubules may pose longer term toxicity issues. mAb-based targeted alpha-particle delivery may be advantageous with less expected myelosuppression than seen with β-emitters. Experimental procedures: To optimize labeling of humanized DOTA-J591 mAb, actinium-225 (225Ac) nitrate was obtained from Oak Ridge National Laboratories and was dissolved in HCl solution and then mixed with trimethyl ammonium acetate and L-ascorbic acid. This preparation was incubated with DOTA-J591. The labeling efficiency (LE) was determined by ITLC-SG. If the LE is &amp;gt;60%, 225Ac-DOTA-J591 mAb was purified by gel filtration and sterilized by membrane filtration. In a pilot pre-clinical study, we studied the toxicity in non-tumor bearing BALB/c mice. Results: The radiochemical purity is &amp;gt;95% and the immunoreactivity was &amp;gt;80%. Twenty-five BALB/c mice received from 2.1 to 6.3 KBq of 225Ac-J591. Treatment was well tolerated, with all mice alive and healthy at Day 26. Conclusions: A stable alpha emitting-antibody complex has been produced with 225Ac-J591. Initial mouse safety experiments have been successful. A RIT dose escalation study of PSMA-targeted alpha emitter in a LNCaP xenograft model is underway. Citation Format: Jaspreet S. Batra, He Liu, Sae Kim, Vicente N. Navarro, Shankar Vallabhajosula, Scott T. Tagawa, Neil H. Bander. PSMA-targeted alpha radioimmunotherapy for prostate cancer with 225Ac-J591 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5201. doi:10.1158/1538-7445.AM2017-5201
Features of Transport in Ultrathin Gold Nanowire Structures (2012)

The origin of the interface formation appearing due to the realization of contacts to ultrathin gold nanowire devices is revealed. Such interfaces play an important role in transport mechanisms in nanowire structures and can determine the electrical and operating parameters of a nanodevice. Based on experimental results, the specific electrical properties of bundles of ultrathin gold nanowires fabricated by wet chemical synthesis and subsequently assembled and contacted with gold electrodes are reported. It is demonstrated that these properties are strongly affected by the monolayers of organic molecules inevitably present on the surface of the nanowires due to synthetic conditions. In particular, such layers form a potential barrier to tunneling of the electrons from contacts to the nanowires. The electric transport behavior of the investigated nanowire structures in the temperature range from 500 mK to 300 K obeys the model of thermal fluctuation-induced tunneling conduction through the nanowire-metal electrode molecular junction. Application of this model allows calculation of the parameters of the molecular potential barrier. The formation of such a molecular barrier is verified by scanning tunneling microscope (STM) and transmission electron microscope (TEM) measurements performed using a supporting graphene layer. These findings are important for designing novel nanodevices for molecular electronics on the basis of ultrathin nanowires.
Expression of endo-beta-mannanase and SNF-related protein kinase genes in true potato seeds in relation to dormancy, gibberellin and abscisic acid. (2009)

Investigations are described into the expression of endo-β-mannanase [β-mannosidase] and SNF1 (sucrose non-fermenting)-related protein kinase (SnRK) genes in relation to primary dormancy of true potato seeds (TPS). Also tested was whether fluridone influenced germination of dormant TPS and, if so, whether it also altered expression of mannanase and SnRK genes. Results indicated that while gibberellins can directly initiate processes leading to radicle protrusion, residual dormancy (possibly due to continued abscisic acid (ABA) synthesis) represses reserve mobilization pathways and limits seedling vigour. Conversely, fluridone may act primarily in the embryo or on reserve mobilization processes, and only indirectly on endosperm cap weakening, explaining its delayed effect on mannanase expression.
Location of crosslinks in chemically stabilized horseradish peroxidase: Implications for design of crosslinks (2001)

The bifunctional compound, ethylene-glycol bis(N-hydroxysuccinimidylsuccinate) (EGNHS), stabilizes horseradish peroxidase C (HRP) by reaction with the enzyme's lysine residues. In this study we compare native and modified HRP by proteolytic fragmentation, peptide sequencing, and mass spectroscopy, and identify the sites of modification. Most significantly, EGNHS is shown to form a crosslink between Lys232 and Lys241 of HRP and modifies Lys174 without formation of a crosslink. These findings are in agreement with the lysine side-chain reactivities predicted from the surface accessibility of the amino groups, and the maximal span of 16 A of the EGNHS crosslinker.
L'esperienza del new labour (2014)

I governi New Labour hanno profondamente trasformato la Gran Bretagna inventando un cocktail originale composto da tre quarti di riforme neoliberiste e antiliberali ispirate dall'esempio americano, un poco di social-democrazia scandinava e un forte desiderio di sperimentazione. Governando il Paese e il Partito a forza di slogan e indicatori di performance, mischiati a una convinzione e una leadership straordinarie, Tony Blair e riuscito a far accettare ai cittadini una serie di riforme radicali dell'amministrazione e dei servizi pubblici. Gordon Brown, meno popolare, e giunto al governo in una situazione di crisi economica senza precedenti... aggravata dalle politiche implementate dai suoi stessi predecessori. I neolaburisti, dopo tre mandati elettorali, sono finiti usurati dal potere e senza piu ispirazione.
Il New Labour e un buon modello a cui puo ispirarsi la sinistra italiana ed europea?
Perche e stato sconfitto cosi clamorosamente alle ultime elezioni ? Dopo tanta enfasi e clamore sulla proposta iniziale di una Terza via, cosa e stato veramente in grado di fare, e con quali esiti ? Il Regno Unito e oggi una societa piu giusta ?
Il libro presenta un bilancio e una brillante analisi dei governi neolaburisti di Tony Blair e Gordon Brown (1997-2010): una rivoluzione burocratica che continua a diffondersi in Italia e in Europa, e che merita di essere conosciuta e discussa a fondo come segnalano la prefazione di Roberto Biorcio e Tommaso Vitale e la postfazione di Fabrizio Barca.
Degradation of Hole Transport Materials via Exciton-Driven Cyclization (2017)

Organic light-emitting diode (OLED) displays have been an active and intense area of research for well over a decade and have now reached commercial success for displays from cell phones to large format televisions. A more thorough understanding of the many different potential degradation modes which cause OLED device failure will be necessary to develop the next generation of OLED materials, improve device lifetime, and to ultimately improve the cost vs performance ratio. Each of the different organic layers in an OLED device can be susceptible to unique decomposition pathways, however stability toward excitons is critical for emissive layer (EML) materials as well as any layer near the recombination zone. This study will specifically focus on degradation modes within the hole transport layer (HTL) with the goal being to identify the general decomposition paths occurring in an operating device and use this information to design new derivatives which can block these pathways. Through post-mortem analyses of several aged OLED devices, an apparently common intramolecular cyclization pathway has been identified that was not previously reported for arylamine-containing HTL materials and that operates parallel to but faster than the previously described fragmentation pathways.
Parallelization of CABAC transform coefficient coding for HEVC (2012)

Data dependencies in CABAC make it difficult to parallelize and thus limits its throughput. The majority of the bins processed by the CABAC are used to represent the prediction error/residual in terms of quantized transform coefficients. This paper provides an overview of the various improvements to context selection and scans in transform coefficient coding that enable HEVC to potentially achieve higher throughput relative to AVC/H.264. Specifically, it describes changes that remove data dependencies in significance map and coefficient level coding. Proposed and adopted techniques up to HM-4.0 are discussed. This work illustrates that accounting for implementation cost when designing video coding algorithms can result in a design that can enable higher processing speed and reduce hardware cost, while still delivering high coding efficiency.
Cold Spraying of Inconel 625 Thick Deposits (2023)

Abstract Cold spraying (CS) of high strength materials, e.g., Inconel 625 is still challenging due to the limited material deformability and thus high critical velocities. Further fine tuning and optimization of cold spray process parameters is required, to reach higher particle impact velocities as well as temperatures, while avoiding nozzle clogging. Only then, sufficiently high amounts of well-bonded particle-substrate and particle-particle interfaces can be achieved, assuring high cohesive strength and minimum amounts of porosities. In this study, Inconel 625 powder was cold sprayed on carbon steel substrates using N2 as propellant gas under different refined spray parameter sets and powder sizes for a systematic evaluation. Coating microstructure, porosity, electrical conductivity, hardness, cohesive strength and residual stress were characterized in as-sprayed condition. Increasing the process gas temperature or pressure leads to low coating porosity of less than 1 % and higher electrical conductivity. The as-sprayed coatings show microstructures with highly deformed particles and well bonded internal boundaries. X-ray diffraction reveals that powder and deposits are present as γ- solid-solution phase without any precipitations. By work hardening and peening effects, the deposits show high microhardness and compressive residual stresses. With close to bulk material properties, the optimized deposits should fulfill criteria for industrial applications.
Influence des propriétés physico-chimiques sur la distribution de tailles de bulles (2005)

L'effet des propriétés physico-chimiques (densité liquide, viscosité et tension superficielle) sur la distribution de taille de bulles est étudié, dans un appareillage de taille réduite, à l'aide d'une caméra. Cette étude est d'abord menée en liquides purs, milieux choisis de manière à ne différer du liquide de référence, le cyclohexane, que par une seule propriété. Ensuite, des mélanges aqueux d'eau et de butanol sont étudiés, afin d'évaluer les différences entre les milieux purs et les mélanges, mais aussi de tester la validité de la démarche industrielle simulant le comportement des liquides industriels organiques par des mélanges aqueux.&#13;\nIl découle de cette étude, réalisée pour des vitesses d'éjection élevées comprises entre 1 et 22m/s, que l'effet le plus influent en liquide purs est la tension superficielle, de la viscosité et de la densité liquide ne suffit pas à prédire la distribution de tailles de bulles. Pour les mélanges aqueux, la même conclusion invalide le principe de fluide modèle.
Influence of Acoustically Excited Airflows on a Planar Airblast Prefilmer (2021)

Abstract In order to meet the higher requirements for clean combustion technology in aircraft engine applications and thus reduce harmful emissions, especially nitrogen oxide emissions, the major jet engine manufacturers are developing lean premixed prevaporized (LPP) combustors that operate at very high pressure. In this context, thermoacoustic instabilities may occur within the combustion chamber. The unsteady heat released by the flame generates pressure waves, which are coupled to the inlet air velocity by a feedback loop. This loop amplifies the instabilities of the inlet air velocity, which in turn influences the atomization process. Since the atomization process at the airblast atomizers of most jet engine combustors determines critical operating characteristics such as air-to-fuel ratio (AFR), flame stability, or NOx emissions, predicting the performance of this process under unsteady conditions has a significant value. The present experimental study focuses on the influence of oscillating airflows on the spray characteristics at the airblast atomization process. The experimental setup was based on a two-dimensional prefilmer where a water film flow was introduced on one surface. The airflow was excited by a siren, whereby an excitation frequency near 94 Hz was investigated. The airflow oscillation under this excitation frequency was characterized using a Constant Temperature Anemometer (CTA), while the generated spray was investigated with a Phase Doppler Anemometry (PDA) system. The spray was investigated in a variety of positions along the radial axis, providing spatial information, apart from temporal. The characterization of the spray via PDA includes a two-component droplet velocity detection and diameter measurement, while the spray mass flux for each measured position was also calculated. The acquired data were phase averaged via an in-house developed processing algorithm, while through a statistical analysis the confidence intervals of the calculations were included. The excitation frequency strongly influenced all spray characteristics, namely, the Sauter Mean Diameter (SMD), the droplet velocities, the mass flux, as well as the local air-to-liquid ratio (ALR). Depending on the phase angle, the size distribution of the spray changes, explaining the observed oscillating behavior of the spray characteristics.
Synthetic eye prosthesis (2012)

Abstract Purpose Development of synthetic eye prosthesis to provide a long term stable keratoprostesis Methods Synthetic hydrophobic and hydrophilic biomaterials were selectively modified by physical and chemical nanotechnological methods. The modified biomaterials were tested in cell culture experiments (fibroblasts L929 and primary epithelial cells, porcine) and implanted into rabbits eyes. The hydrophobic material was implanted finally into eyes of ultima ratio patients. Results After very successful in vitro evaluation, keratoprostheses were implanted to rabbit eyes (New Zealand white rabbit) and showed excellent in vivo performance in the animal experiment.As for the hydrophibic material, no adverse reaction was observed after follow up of 2.5 years in human eyes. Conclusion We could develop a new keratoprosthesis which is well tolerated in human eye.
Light‐Driven Micromotors: Light‐Driven Sandwich ZnO/TiO2/Pt Janus Micromotors: Schottky Barrier Suppression by Addition of TiO2 Atomic Interface Layers into ZnO/Pt Micromachines Leading to Enhanced Fuel‐Free Propulsion (Small Methods 11/2019) (2019)

In article number 1900258 by Martin Pumera and co-workers, new light-driven ZnO/TiO2/Pt Janus micromotors with atomically smooth interfaces that can move faster than conventional ZnO/Pt are presented. The new ZnO/TiO2 type II heterojunction interfaces are used for the first time in light-driven micromotors to suppress the Schottky barrier, resulting in a highly efficient charge transfer/separation and faster speed for heavy carriers.
The ATC-Wake Predictor system and its potential use to increase the capacity at airports (2005)

The ATC-Wake project is funded by the EC under the “Information Society Technology” Programme. Main objective is the development of an Air Traffic Control Wake Vortex Safety and Capacity Integrated Platform (IP). This IP is used to evaluate interoperability with existing ATC systems, to assess possible safety and capacity improvements, and to evaluate operational usability and acceptability for air traffic controllers. It constitutes an essential step for installation of an “integrated ATC decision support system” at airports, enabling air traffic controllers to safely apply new optimised weather based aircraft spacing. The system integrates four new wake-vortex related subsystems: a Separation Mode Planner component (based on a weather forecasting and nowcasting system), a Predictor component (based on the weather nowcasting system and on a wake vortex prediction system), a Detector component (based on weather and wake sensors), a Monitoring and Alerting component (which notifies the air traffic controllers in case of a discrepancy between prediction and detection information), as well as Human Machine Interfaces to the controllers. Used in combination with new wake vortex safety regulation, the ATC-Wake System will provide both tactical and strategic benefits, while maintaining the required level of safety. This paper focuses on the ATC-Wake Predictor, which predicts for individual aircraft the wake vortex behavior in the pre-defined arrival or departure area(s). Prediction is performed using probabilistic wake vortex prediction models fed by real-time meteorological data (most recent nowcast data as well as ground or down-linked airborne measurements) from the time the aircraft reaches a critical arrival area entry until it lands and from the take-off until it leaves the critical departure area. The prediction quality being directly related to input data quality (meteorological and radar data), a safety buffer is applied to satisfy accuracy requirements of Air Traffic Controllers and/or regulatory authorities. The prediction is updated in short intervals (6 seconds) and the information is provided to ATC through a HMI in the form of a Wake Vortex Vector. It is also vaulted/assessed by wake vortex measurements (performed by the Detector) .
Expression of Genes for Intracisternal A-Particle Antigen in Somatic Cell Hybrids (1974)

Journal Article Expression of Genes for Intracisternal A-Particle Antigen in Somatic Cell Hybrids Get access John D. Minna, John D. Minna Search for other works by this author on: Oxford Academic PubMed Google Scholar Kira K. Lueders, Kira K. Lueders Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward L. Kuff Edward L. Kuff Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1211–1217, https://doi.org/10.1093/jnci/52.4.1211 Published: 01 April 1974 Article history Received: 20 September 1973 Accepted: 03 January 1974 Published: 01 April 1974
DDEF1 Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma (2005)

These findings suggest that DDEF1 overexpression may be a pathogenetically relevant consequence of chromosome 8q amplification, which commonly occurs in high-grade uveal melanomas. We conclude that DDEF1 may act as an oncogene in this cancer, and it may be a useful diagnostic marker and therapeutic target.
Treatment of gingival recession in the anterior mandible using the tunnel technique and a combination epithelialized-subepithelial connective tissue graft-a case series. (2011)

Covering exposed roots becomes more and more difficult as the gingiva becomes thinner and the vestibule becomes more shallow. Also, the outcome becomes less predictable. In addition, where there is high frenal attachment or muscle pull, such as the mentalis muscle in the mandibular anterior region, secondary retraction of a coronally advanced flap will likely occur. Therefore, a transplanted connective tissue graft may not completely cover the recession. This case series presents a technique where the roots are covered with a combination epithelialized-subepithelial connective tissue graft. The epithelialized portions of the graft are positioned directly over the exposed roots to aid in resistance to the environment of the mouth, and there is no displacement of the mucogingival junction or flattening of the vestibule.