gebhart/patrepeval huggingface dataset:
A new method to measure regional myocardial time-varying elastance using minute vibration (1998)

We developed a new technique to evaluate regional myocardial elastance using minute vibration. In 13 isolated cross-circulated canine hearts, we applied small sinusoidal vibrations of displacement to the left ventricular surface at various frequencies (50-100 Hz). Using the measured displacement and force between the vibrator head and myocardium, we derived myocardial elastance on the basis of the equation of motion for a given moment of the cardiac cycle. Simultaneous solution of the equations of motion at different frequencies yielded a unique value of elastance. Time-varying myocardial elastance increased from diastole (0.028 +/- 0.211 x 10(6) dyn/cm) to systole (0.833 +/- 0.391 x 10(6) dyn/cm). The end-systolic elastance (ees) linearly correlated with end-systolic left ventricular elastance (r = 0.717, P < 0.001) and also with the end-systolic Young's modulus (r = 0.874, P < 0.0001). We also measured ees at both ischemic and nonischemic regions during coronary occlusion. Young's modulus, estimated by normalizing ees by the wall thickness and by the estimated mass, did not change significantly at the nonischemic regions, whereas it decreased significantly from 2.303 +/- 0.556 to 1.173 +/- 0.370 x 10(6) dyn/cm2 at the ischemic region after coronary occlusion (P < 0.005). We conclude that this technique is useful for the quantitative assessment of regional myocardial elastance.
ChemInform Abstract: Solid‐State Polymer Light‐Emitting Electrochemical Cells: Recent Developments (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Xenon Fluoride Laser Beam Combining using Stimulated Raman Scattering Techniques (1988)

Single pass Raman amplification experiments were conducted in hydrogen using two xenon fluoride laser beams originating from the same laser device. These beams were crossed at shallow angles (milliradians) using a Mach-Zehnder optical arrangement. A seed beam at the hydrogen vibrational Stokes shifted wavelength of 414 nm was aligned to bisect the angle made by the two pump beams.
Scripting Documents with XQuery: Virtual Documents in TNTBase (2010)

This paper introduces the concept of Virtual Documents and its prototypical realization in our TNTBase system, a versioned XML database. Virtual Documents integrate XQuery-based computational facilities into documents like JSP/PHP do for relational queries. We view the integration of computation in documents as an enabling technology and evaluate it on a handful of real-world use cases.
Hyperacuity on high-resolution and very high resolution displays (2004)

A vernier acuity task was used to compare three electronic displays, a high-resolution CRT, a high-resolution AMLCD, and a very-high-resolution AMLCD. The offset threshold value, approximately 6 seconds arc, was found to be independent of display resolution. The very-high-resolution display had one octave more positional accuracy than the high-resolution displays. This performance difference was readily apparent. To match the image quality of print or photographic reconstruction, a very-high-resolution screen is required.
Low voltage, high resolution studies of electron beam resist exposure and proximity effect (1992)

Resist exposure characteristics have been studied over a voltage range from 1 to 10 kV in order to demonstrate the feasibility of using low voltage electron beam lithography (EBL) to pattern submicron features without the proximity effect problems seen at higher voltages. The exposures were done by modifying a 25 kV thermal field emission EBL machine to run in a retarding field configuration where the sample is biased at a large negative potential, thus reducing the final beam landing energy. After analyzing the linewidths of various proximity test patterns with features as small as 0.15 μm, we conclude that at these dimensions the proximity effect on silicon substrates, compared to 10 kV, is greatly reduced at 5 kV and almost negligible at 3 kV. In order to maintain resolution at these low voltages, it is normally necessary to reduce the beam current due to increased aberrations and reduced source brightness. However, calculations and experiments show that these problems are much less severe in the retarding field configuration, where the electron beam is accelerated to a high potential through most of the optical path length and then reduced to the working voltage just before striking the workpiece. In addition, the reduced beam current is compensated by an almost corresponding increase in the resist sensitivity. Thus, low voltage is shown to be an effective means of avoiding the proximity effect, and a tool using the combination of a thermal field emission electron source and a retarding field final lens is shown to have the resolution and beam current required to expose patterns at the required voltage with reasonable throughput.
Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: A genetic and biochemical analysis (1970)

Abstract The synthesis, assembly, and secretion of gamma globulin has been examined using cells from a mouse plasma cell tumor. The cells were then adapted to continuous culture and individual clones were obtained which differed from each other in the relative amounts of heavy and light chains synthesized, in the absolute amounts of gamma globulin being produced, and in the details of the assembly process. Finally, the kinetics, pathway, and completeness of assembly were examined in a variety of tumors and variants of these tumors.
Life surface inference for endurance characterization of PET specimens in multi-stress conditions (2002)

In this paper, the results of electrical and multi-stress life tests performed on flat specimens of polyethylene-terephthalate are examined taking into account the geometrical approach to combined-stress life. This allows, besides the electrical and thermal life graphs, the isochronal lines in E vs T coordinates to be plotted. In this way, the whole life surface of the tested material can be displayed, thus obtaining a complete description of its multi-stress behaviour.
Status of mid-IR fibers (1989)

Fluoride glasses are being considered for use in long distance mid-IR transmitting optical fibers. The multiphonon edge of these fibers is shifted to longer wavelengths compared with silica fibers. The intrinsic loss is, therefore, lower (≤0.01 dB/km) and occurs at −2.5 μm. Uses for these fibers include ultralow-loss communication links, radiation resistant links, remoting of IR focal plane arrays, IR power delivery, low-temperature sensors, and medical and remote spectroscopic analysis. In addition, this ultralow-loss optical fiber may be used for fiber guided missiles with ranges of &gt;500 km. Most of the interest, however, has been focused on development of very long (thousands of kilometers) repeaterless communication links. Such repeaterless links may decrease system cost and cable weight while increasing overall reliability and ease of repair compared to silicate optical fibers.
Active load characterization of a microwave transistor for oscillator design (2002)

This paper describes the use of a six-port active load measurement system to determine the optimal large-signal loading of transistors for the design of microwave oscillators providing maximum output power. Our system has been used to measure the optimal large-signal terminating impedance for a potentially unstable microwave transistor and to apply the device line characterization technique. This technique, which is used to characterize a negative resistance monoport and predict the level of oscillator output power, is implemented for the first time using active loading. An oscillator designed using our measurements generated an output power of 11.3 dBm at a frequency of 3.5 GHz. This result is in good agreement with the value predicted from the device line technique and our measurement system.
NCCN Oncology Research Program's Investigator Steering Committee and NCCN Best Practices Committee Molecular Profiling Surveys (2015)

Results indicated that molecular profiling/diagnostics are used at 100% of survey respondents' institutions to make patient care decisions. However, challenges relating to reimbursement, lack of data regarding actionable targets and targeted therapies, and access to drugs on or off clinical trials were cited as barriers to integration of molecular profiling into patient care. Frameworks for using molecular diagnostic results based on levels of evidence, alongside continued research into the predictive value of biomarkers and targeted therapies, are recommended to advance understanding of the role of genomic biomarkers. Greater evidence and consensus regarding the clinical and cost-effectiveness of molecular profiling may lead to broader insurance coverage and increased integration into patient care.
The Decomposition of Sulfur Ylids to Carbenes (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Decomposition of Sulfur Ylids to CarbenesVictor J. Hruby and A. William. JohnsonCite this: J. Am. Chem. Soc. 1962, 84, 18, 3586–3587Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/ja00877a035https://doi.org/10.1021/ja00877a035research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Summary of the Large Civil Tiltrotor (LCTR2) Engine Gearbox Study (2010)

In support of the Fundamental Aeronautics Program, Subsonic Rotary Wing Project, NASA is continuing to study the Large Civil Tiltrotor (LCTR) concept to help define/refine vehicle, system and subsystem attributes. These attributes can then be used to define performance requirements and identify new or advanced technologies to achieve an operational vehicle class. As part of this goal, NASA contracted with The Boeing Company and its subcontractor Rolls-Royce to perform an investigation of different combinations of engine and gearbox variability to achieve a maximum of 50 percent rotor tip speed reduction from hover to cruise conditions. Previous NASA studies identified the 50 percent rotor speed reduction minimized vehicle gross weight and fuel burn. The LCTR2 (LCTR-iteration 2) was the contracted study baseline for initial sizing. Rotor tip speed ratios (cruise to hover) of 100, 77, and 54 percent were analyzed for each combination of engine and gearbox speed reduction to achieve the chosen rotor tip speed ratio. Three different engine and gearbox technology levels were assumed; commercial off-the-shelf (COTS), entry-in-service (EIS) in 2025 and EIS in 2035. These technology levels were applied to determine each particular effect on vehicle gross weight and fuel burn, while other vehicle technologies were assumed constant. This report summarizes the work performed that is being put together into a comprehensive NASA contractor report. Some background on the LCTR concept and baseline vehicle will be given and then a discussion concerning the technical approach utilized. Major study assumptions and results will be presented and discussed. Finally conclusions will be drawn as well as suggestions provided for future efforts.
Enabling low-resolution ADC with high-order modulations for millimeter-wave systems (2016)

We describe a new approach to improve the success rate of symbol decoding with very high-order modulations at receivers equipped with low-resolution analog-to-digital converters (ADC). The proposed method is based on generating self-inflicting pseudo-random white noise signal at the receiving antenna array in order to improve the performance of spatial oversampling. As the optimal amount of this artificially induced noise strongly depends on the ADC resolution, transmit symbol modulation, and the number of receive antennas, we design an adaptation mechanism to render an acceptable balance for successful decoding between the inner- and outer-region symbols of the constellation. Numerical findings demonstrate, for the first time, that the feasibility of high-order symbol modulations (e.g., 64/256-QAM) is within reach by low-resolution ADCs.
Abstract IA01: Single cell analysis of CRISPR T cells (2020)

Abstract CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a first-in-human phase 1 clinical trial to test the safety and feasibility of multiplex CRISPR-Cas9 editing to engineer T cells in three patients with refractory cancer. Two genes encoding the endogenous T cell receptor (TCR) chains, TCRα (TRAC) and TCRβ (TRBC), were deleted in T cells to reduce TCR mispairing and to enhance the expression of a synthetic, cancer-specific TCR transgene (NY-ESO-1). Removal of a third gene encoding programmed cell death protein 1 (PD-1; PDCD1), was performed to improve antitumor immunity. Adoptive transfer of engineered T cells into patients resulted in durable engraftment with edits at all three genomic loci. Although chromosomal translocations were detected, the frequency decreased over time. Modified T cells persisted for up to 9 months, suggesting that immunogenicity is minimal under these conditions and demonstrating the feasibility of CRISPR gene editing for cancer immunotherapy. Citation Format: Edward Stadtmauer, Joseph Fraietta, Ansuman Satpathy, Carl H. June. Single cell analysis of CRISPR T cells [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr IA01.
Synthesis of Well-Aligned Diamond Nanocylinders (2001)

Alumina templates are used to assist the deposition of highly ordered polycrystalline diamond nanocylinders (see Figure) and diamond-like carbon nanotubes. The growth of diamond is carried out by microwave plasma-assisted CVD, using acetone as the carbon source. The dimensions of the nanofibers are easily controllable and this technique could be adopted to prepare arrays for various applications.
Tensor description of physical properties of crystals (1975)

The use of tensors for describing the physical properties of crystals is not particularly widespread in undergraduate curricula. Tensor concepts, however, are unavoidable in describing the properties of anisotropic media, of which crystals are a very important example. This paper describes suggested introductory material on tensors for use in an undergraduate materials science course. Special emphasis has been placed on communicating the basic tensor concepts through the use of examples. Mathematical manipulations have intentionally been minimized.
Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant (2018)

Influenza epidemics occur annually, and estimated 5-10% of the adult population and 20-30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal surface antigen hemagglutinin (HA). This important role of HA-specific antibodies explains why previous pandemics have emerged when new HAs have appeared in circulating human viruses. It has long been recognized that influenza virus-specific CD4(+) T cells are important in protection from infection through direct effector mechanisms or by providing help to B cells and CD8(+) T cells. However, the seasonal influenza vaccine is poor at inducing CD4(+) T-cell responses and needs to be combined with an adjuvant facilitating this response. In this study, we applied the ferret model to investigate the cross-protective efficacy of a heterologous trivalent influenza split-virion (TIV) vaccine adjuvanted with the CAF01 adjuvant, with proven ability to induce CD4(+) T-cell and antibody responses in mice, ferrets, pigs, primates, and humans. Our results indicate that CAF01-adjuvanted vaccine induces HA inhibition (HAI)-independent protection after heterologous challenge, manifested as reduced viral load and fever. On the other hand, we observe increased inflammation in the airways and more neutrophil and mononuclear cell infiltration in these ferrets when compared with optimally protected animals, i.e., ferrets receiving the same vaccine but a homologous challenge. This suggest that HAI-independent immunity induced by TIV + CAF01 can reduce viral shedding and systemic disease symptoms, but does not reduce local inflammation in the nasal cavity.
CHEMIEXCITATION IN THE ARACHIDONIC ACID CASCADE (1991)

As investigated in neutrophils, the very weak luminescence accompanying the arachidonic acid cascade is associated with the lipoxygenase pathway. The emission is dramatically enhanced by energy transfer to chlorophyll a. The number of chlorophyll molecules excited to the fluorescent state per oxygen consumed, (the S1/O2 ratio), equal to the product of the quantum yields of chemiexcitation and of energy transfer, is 5.4 x 10(-6). The quantum yield of chemiexcitation is inferred to be higher than 1 x 10(-3). The two most likely chemiexcitation routes point to triplet conjugated carbonyls as the most likely candidates for the excited species that transfer to chlorophyll. As such the emission intensity may reflect the level of hydroperoxyeicosatetraenoic acid. This is the first case where addition of a biotic substrate to a cellular system results in substantial generation of electronic excited states without any drastic loss of cell viability. Whether the formation of excited states in the arachidonic acid cascade in neutrophils is accidental or has a biological role is an open question.
Thermal Stresses From a Moving Band Source of Heat on the Surface of a Semi-Infinite Solid (1978)

Thermoelastic stresses arising from a moving band source of heat on the surface of a semi-infinite solid have been calculated using well-known temperature solutions and a finite element stress analysis. Results are presented in nondimensional form for a wide range of conditions for both quasi-steady state and transient regimes. The effect of convective cooling at the surface has also been investigated. Peak stresses, which occur at the surface, have been related to a modified source Peclet number for instances in which surface cooling is not employed. Reduction in stress levels due to convective cooling at the surface has also been determined. For all cases considered, the greatest stress levels were found to occur at the surface of the constrained direction. Using results obtained in this study, thermoelastic stresses in sliding and machining processes may be calculated in order to predict the onset of yielding which can result in residual tensile stresses and cracking.
Acid-Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: An Investigation on the Synthesis of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters. (2005)

For Abstract see ChemInform Abstract in Full Text.
Welcome program chairs (2014)

Welcome to HOT CHIPS 26, the 26th anniversary conference. A look back over these 26 years shows the amazing progress made in computer engineering. This progress can be measured in terms of performance, cost, density and versatility of function. These technological advances have brought advances in functionality, creating new companies, new markets and indeed new patterns of socialization.
Data regeneration and disturb immunity of T-RAM cells (2014)

This work presents the first in-depth investigation of data regeneration and disturb immunity of T-RAM cells. Experimental results on deca-nanometer devices reveal that read operations do not compromise cell memory state, contributing, however, to its regeneration only when repeated at high frequency. The separate role of the word-line and the bit-line bias during read is then studied in detail, presenting a clear picture of the physical processes taking place in the device. In so doing, the impact of electrical disturbs on unselected cells coming from read operations in the array are comprehensively addressed.
Deep Tissue Photoacoustic Imaging Using a Miniaturized 2-D Capacitive Micromachined Ultrasonic Transducer Array (2012)

In this paper, we demonstrate 3-D photoacoustic imaging (PAI) of light absorbing objects embedded as deep as 5 cm inside strong optically scattering phantoms using a miniaturized (4 mm × 4 mm × 500 μm), 2-D capacitive micromachined ultrasonic transducer (CMUT) array of 16 × 16 elements with a center frequency of 5.5 MHz. Two-dimensional tomographic images and 3-D volumetric images of the objects placed at different depths are presented. In addition, we studied the sensitivity of CMUT-based PAI to the concentration of indocyanine green dye at 5 cm depth inside the phantom. Under optimized experimental conditions, the objects at 5 cm depth can be imaged with SNR of about 35 dB and a spatial resolution of approximately 500 μm. Results demonstrate that CMUTs with integrated front-end amplifier circuits are an attractive choice for achieving relatively high depth sensitivity for PAI.
Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells (2022)

The Tmod mechanism exemplified by the MSLN CAR Tmod construct provides an alternative route to leverage solid-tumor antigens such as MSLN in safer, more effective ways than previously possible.