gebhart/patrepeval huggingface dataset:
Preparation and evaluation of polyethyleneimine-single walled carbon nanotube conjugates as vectors for pancreatic cancer treatment (2014)

High quality single-walled carbon nanotubes (SWNTs) were obtained following a new purification procedure, based on using Cl<sub>2</sub> gas at high temperature. Cl<sub>2</sub>-treated SWNTs were fluorinated and modified with branched polyethyleneimine (PEI) to afford covalently functionalised PEI-SWNTs, which were then tested for cytotoxicity both in vitro (HPNE and BxPC3 pancreatic cell lines) and in vivo (BxPC3 xenografts from nude mice) to establish that functionalization with lower molecular weight PEI (600 and 1800 Da) achieved higher cell viability in MTT assay. A shortened version of the nanotubes, PEI(1800)-cut-SWNT (1800 Da branched PEI), was also prepared and tested for cellular internalization in the BxPC3 adenocarcinoma cell line. Laser confocal imaging of the cells after incubation in the presence of RhoB-PEI(1800)-cut-SWNT (covalently labelled with rhodamine B) indicates that the PEI(1800)-cut-SWNTs can reach both the cytoplasm and nucleus of pancreatic cancer cells.
Novel Hybrid Morpholino-Glycopeptides with the Amino Acid Nitrogen Replacing C-3 of the Pyranose Ring (1997)

Periodate oxidation of glycopyranosides yields dialdehydes that can be reductively aminated in the presence of amino acids to produce hybrid glycopeptides where the amino acid nitrogen is inserted into the resulting 2,4-dideoxypyranoside at position 3. Nine such 3-morpholino derivatives were prepared, including a disaccharide analog of N-acetyllactosamine (β-Gal(1→4)βGlcNAc) where the nitrogen of glycine was inserted into the galactose ring. The resulting hybrid disaccharide was an excellent substrate for a mild fucosyltransferase which converted it to a novel functionalized LeX mimic.
4. D (2002)

PreviousNext No AccessEncyclopedic Dictionary of Applied Geophysics, Fourth edition4. DAuthors: Robert E. SheriffRobert E. SheriffProfessor, University of Houstonhttps://doi.org/10.1190/1.9781560802969.chd SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.9781560802969.chdFiguresReferencesRelatedDetails Encyclopedic Dictionary of Applied Geophysics, Fourth edition ISBN (print):978-1-56080-118-4ISBN (online):978-1-56080-296-9 Copyright: 2002 Pages: 442 publication data© 2002 All rights reserved. No part of this publication may be reproduced or distributed in any form or by any means without written permission of the publisherPublisher:Society of Exploration Geophysicists HistoryPublished in print: 01 Jan 2002 CITATION INFORMATION Robert E. Sheriff, (2002), "4. D," Geophysical References Series : 78-111. https://doi.org/10.1190/1.9781560802969.chd Plain-Language Summary PDF DownloadLoading ...
Magnetoresistance and Microstructure of Magnetite Nanocrystals Dispersed in Indium−Tin Oxide Thin Films (2009)

Epitaxial indium-tin oxide (ITO) thin films were fabricated on a yttria-stabilized zirconia (YSZ) substrate by pulsed-laser deposition using magnetite (Fe(3)O(4)) nanoparticle dispersed ITO powders as a target. Magnetoresistance of the film at a field of 1 T was 39% at 45 K, and it stayed at 3% above 225 K. The film demonstrated cooling hysteresis in the temperature dependence of direct-current magnetization. Transmission electron microscopy revealed that phase-separated Fe(3)O(4) nanocrystals with widths of approximately 40-150 nm and heights of approximately 10-25 nm precipitated and grew epitaxially on the substrate in the film. Both the Fe(3)O(4)(111) and ITO(001) planes were parallel to the YSZ(001) plane. The Fe(3)O(4)(11-2) and -(1-10) planes were parallel to the ITO(100) and -(010) planes, respectively, and the planes connected smoothly at the grain boundary. The contour map of the electron density for the Fe(3)O(4)(111) plane by the first-principles electronic structure computation was similar to that for the ITO(001) plane. The [111]-oriented Fe(3)O(4) nanocrystals played the role of spin aligner for charge carriers of the epitaxial ITO film.
Assignment of the dystonia-parkinsonism syndrome locus, DYT3, to a small region within a 1.8-Mb YAC contig of Xq13.1. (1995)

A YAC contig was constructed of Xq13.1 in order to sublocalize the X-linked dystonia-parkinsonism (XDP) syndrome locus, DYT3. The contig spans a region of approximately 1.8 Mb and includes loci DXS453/DXS348/IL2R gamma/GJB1/CCG1/DXS559. For the construction of the contig, nine sequence-tagged sites and four short tandem repeat polymorphisms (STRPs) were isolated. The STRPs, designated as 4704#6 (DXS7113), 4704#7 (DXS7114), 67601 (DXS7117), and B4Pst (DXS7119) were assigned to a region flanked by DXS348 proximally and by DXS559 distally. Their order was DXS348/4704 #6/4704 #7/67601/B4Pst/DXS559. They were applied to the analysis of allelic association and of haplotypes in 47 not-obviously-related XDP patients and in 105 Filipino male controls. The same haplotype was found at loci 67601 (DXS7117) and B4Pst (DXS7119) in 42 of 47 patients. This percentage of common haplotypes decreased at the adjacent loci. The findings, together with the previous demonstration of DXS559 being the distal flanking marker of DYT3, assign the disease locus to a small region in Xq13.1 defined by loci 67601 (DXS7117) and B4Pst (DXS7119). The location of DYT3 was born out by the application of a newly developed likelihood method for the analysis of linkage disequilibrium.
What distinguishes tenascin from fibronectin? (1990)

Tenascin and fibronectin are two major extracellular matrix glycoproteins. They both consist of large disulfide-linked subunits composed of multiple structural domains. More than half of each molecule consists of so-called fibronectin type III repeats, but the other domains differ. Fibronectin is a dimer, whereas tenascin is a hexamer. Often fibronectin and tenascin are colocalized in tissues, but the occurrence of tenascin is much more restricted when compared with fibronectin. Tenascin is transiently expressed in many developing organs such as connective tissues, the mesenchyme of epithelial organs, and also the central and peripheral nervous systems, and it reappears in the stroma of many tumors. The distinctive and highly regulated expression of tenascin has provoked interest in trying to identify possible functions of tenascin in cell-cell and cell-substratum adhesion, cell migration, growth, and cell differentiation during morphogenesis.
High integrity carrier phase based positioning for precision landing using a robust nonlinear filter (2010)

In this paper, a cascaded ambiguity resolution scheme is
integrated into an extended Kalman filter for reliable carrier
phase positioning. The state vector includes the user position
and velocity, carrier phase ambiguities and ionospheric and
tropospheric delays which are determined from satellitesatellite
double differenced dual frequency code and carrier
phase measurements. The integrity of the state estimation
is continuously validated by Autonomous Filter-based Fault
Detection, Identification and Model Adaptation (AFDIA).
Cascaded ambiguity resolution is applied to fix the widelane
ambiguities and then the measurement ambiguities.
In this paper, the integer ambiguity resolution is done
sequentially with integer decorrelation. This bootstrapping
enables a success rate which can be determined analytically.
A partial integer decorrelation is used to achieve an optimum
trade-off between variance reduction and bias amplification.
The AFDIA checks the consistency of the ambiguity resolution
and navigation solution at each time step. The algorithm
supplies the user also with an error overbound called the
Vertical and Horizontal Protection Levels (VPL and HPL).
The fixing of the measurement integer ambiguities results in a
substantial reduction of the protection levels. Protection levels
of less than 50 cm have been observed for simulated dual
frequency E1 and E5a Galileo measurements and realistic
flight paths.
Combining Electron-Neutral Building Blocks with Intramolecular “Conformational Locks” Affords Stable, High-Mobility P- and N-Channel Polymer Semiconductors (2012)

Understanding the relationship between molecular/macromolecular architecture and organic thin film transistor (TFT) performance is essential for realizing next-generation high-performance organic electronics. In this regard, planar π-conjugated, electron-neutral (i.e., neither highly electron-rich nor highly electron-deficient) building blocks represent a major goal for polymeric semiconductors, however their realization presents synthetic challenges. Here we report that an easily accessible (minimal synthetic steps), electron-neutral thienyl-vinylene (TVT)-based building block having weak intramolecular S···O "conformational locks" affords a new class of stable, structurally planar, solution-processable, high-mobility, molecular, and macromolecular semiconductors. The attraction of merging the weak TVT electron richness with supramolecular planarization is evident in the DFT-computed electronic structures, favorable MO energetics, X-ray diffraction-derived molecular structures, experimental lattice coehesion metrics, and excellent TFT performance. TVT-based polymer TFTs exhibit stable carrier mobilities in air as high as 0.5 and 0.05 cm(2)/V·s (n- and p-type, respectively). All-TVT polymer-based complementary inverter circuitry exhibiting high voltage gains (~50) and ring oscillator circuitry with high f(osc)(~1.25 kHz) is readily fabricated from these materials by simple inkjet printing.
The mechanism of graft-host-tolerance in murine radiation chimeras transplanted across minor histocompatibility barriers. (1989)

A better understanding of the mechanism(s) involved in graft-host-tolerance following allogeneic bone marrow transplantation is needed to develop new strategies to prevent graft-versus-host disease (GVHD). Based on previous studies, mainly in MHC-mismatched donor-recipient pairs, three hypotheses have been proposed: clonal deletion, active suppression and lack of adequate antigen-presenting cells. Our goal was to identify the mechanism(s) by which tolerance is achieved and maintained in radiation chimeras transplanted across minor histocompatibility barriers. Healthy (B6----LP) chimeras were obtained following injection of 10(7) C57BL/6 marrow cells to irradiated (9.5 Gy) LP hosts and used experimentally 100 days after chimerization. The tolerance state of (B6----LP) chimeras could not be abrogated after i.v. transfer of 5 x 10(7) donor-type spleen cells alone or with repeated i.p. injection of host-type antigen-presenting cells. No GVHD was observed when 10(7) marrow cells plus 5 x 10(7) spleen cells from (B6----LP) chimeras were injected to irradiated LP recipients. Chimera spleen cells suppressed GVHD when adoptively transferred to LP recipients of a C57BL/6 graft. These results suggest that in this model the presence of suppressor cells is both necessary and sufficient to maintain graft-host-tolerance.
Hydrogen detection in high pressure gas mixtures using a twin hole fibre Bragg grating (2011)

A sensor for detecting high-pressure hydrogen gas is presented that is based on Bragg gratings inscribed in a microstructured twin hole optical fibre with femtosecond pulse duration 800 nm radiation and a phase mask. Utilising the well-known variation of refractive index of silica upon exposure to hydrogen gas, the presence of hydrogen results in a shift of the Bragg resonance. The use of a microstructured fibre design allows for more rapid diffusion of H<sub>2</sub> into and out of the fibre core resulting in faster detection of hydrogen gas compared to standard optical fibre. Grating inscription with the femtosecond laser technique allows for sensor operation at high temperatures.
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice (2012)

For an identification of novel candidate genes in thyroid tumourigenesis, we have investigated gene copy number changes in a Trk-T1 transgenic mouse model of thyroid neoplasia. For this aim, 30 thyroid tumours from Trk-T1 transgenics were investigated by comparative genomic hybridisation. Recurrent gene copy number alterations were identified and genes located in the altered chromosomal regions were analysed by Gene Ontology term enrichment analysis in order to reveal gene functions potentially associated with thyroid tumourigenesis. In thyroid neoplasms from Trk-T1 mice, a recurrent gain on chromosomal bands 1C4-E2.3 (10.0% of cases), and losses on 3H1-H3 (13.3%), 4D2.3-E2 (43.3%) and 14E4-E5 (6.7%) were identified. The genes Twist2, Ptma, Pde6d, Bmpr1b, Pdlim5, Unc5c, Srm, Trp73, Ythdf2, Taf12 and Slitrk5 are located in these chromosomal bands. Copy number changes of these genes were studied by fluorescence in situ hybridisation on 30 human papillary thyroid carcinoma (PTC) samples and altered gene expression was studied by qRT-PCR analyses in 67 human PTC. Copy number gains were detected in 83% of cases for TWIST2 and in 100% of cases for PTMA and PDE6D. DNA losses of SLITRK1 and SLITRK5 were observed in 21% of cases and of SLITRK6 in 16% of cases. Gene expression was significantly up-regulated for UNC5C and TP73 and significantly down-regulated for SLITRK5 in tumours compared with normal tissue. In conclusion, a global genomic copy number analysis of thyroid tumours from Trk-T1 transgenic mice revealed a number of novel gene alterations in thyroid tumourigenesis that are also prevalent in human PTCs.
Increased Handpiece Speeds without Air Coolant: Aerosols and Thermal Impact (2022)

This study assessed the impact of increased speed of high-speed contra-angle handpieces (HSCAHs) on the aerosolization of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogate virus and any concomitant thermal impact on dental pulp. A bacteriophage phantom-head model was used for bioaerosol detection. Crown preparations were performed with an NSK Z95L Contra-Angle 1:5 (HSCAH-A) and a Bien Air Contra-Angle 1:5 Nova Micro Series (HSCAH-B) at speeds of 60,000, 100,000, and 200,000 revolutions per minute (rpm), with no air coolant. Bioaerosol dispersal was measured with Φ6-bacteriophage settle plates, air sampling, and particle counters. Heating of the internal walls of the pulp chambers during crown preparation was assessed with an infrared camera with HSCAH-A and HSCAH-B at 200,000 rpm (water flows ≈15 mL min<sup>-1</sup> and ≈30 mL min<sup>-1</sup>) and an air-turbine control (≈23.5 mL min<sup>-1</sup>) and correlated with remaining tissue thickness measurements. Minimal bacteriophage was detected on settle or air samples with no notable differences observed between handpieces or speeds (<i>P</i> > 0.05). At all speeds, maximum settled aerosol and average air detection was 1.00 plaque-forming units (pfu) and 0.08 pfu/m<sup>3</sup>, respectively. Irrespective of water flow rate or handpiece, both maximum temperature (41.5°C) and temperature difference (5.5°C) thresholds for pulpal health were exceeded more frequently with reduced tissue thickness. Moderate and strong negative correlations were observed based on Pearson's correlation coefficient, between remaining dentine thickness and either differential (<i>r</i> = -0.588) or maximum temperature (<i>r</i> = -0.629) measurements, respectively. Overall, HSCAH-B generated more thermal energy and exceeded more temperature thresholds compared to HSCAH-A. HSCAHs without air coolant operating at speeds of 200,000 rpm did not increase bioaerosolization in the dental surgery. Thermal risk is variable, dependent on handpiece design and remaining dentine thickness.
Excitonic Spectrum in CdSe/ZnSe Disordered Superlattices (2000)

Experimental and theoretical studies of an excitonic spectrum are performed in CdSe/ZnSe submonolayer superlattices. Photoluminescence excitation spectra measured in the structures are compared with simulations carried out within the effective mass approximation, using a model with laterally homogeneous ZnCdSe graded-composition layers. The structure parameters used in the model are obtained from X-ray diffraction studies. The agreement between theory and experiments is satisfactory for superlattices with CdSe layers thinner than 0.5 monolayer. The samples with thicker layers display a red shift of the experimental lowest-energy exciton and quenching of its intensity, as compared to the simulations. The observed disagreement is discussed in terms of lateral inhomogeneity of the CdSe-based layers.
Preface to the Focus Issue on Defect Characterization in Semiconductor Materials and Devices (2016)

status: Published
Design Issues in Tissue Engineered Cartilage Replacement (2000)

Abstract Tissue engineered replacement cartilage for the treatment of an arthritic joint must sustain the mechanical demands of normal function. Historically total joint replacement has been the primary method for the treatment of severely degenerated joints. The design of a tissue engineered cartilage replacement has a number of parallels with the design of a total joint replacement. Therefore, it is useful to examine the design process of a total joint replacement in the context of designing a tissue engineered cartilage replacement. This presentation will examine the design requirements for the replacement of articular cartilage at the knee.
DTN routing for quasi-deterministic networks with application to LEO constellations (2015)

We propose a novel DTN routing algorithm, called DQN, specifically designed for quasi-deterministic networks with an application to satellite constellations. We demonstrate that our proposal efficiently forwards the information over a satellite network derived from the Orbcomm topology while keeping a low replication overhead. We compare our algorithm against other well-known DTN routing schemes and show that we obtain the lowest replication ratio with a delivery ratio of the same order of magnitude than a reference theoretical optimal routing. We also analyze the impact of terrestrial gateways density and analyze DQN performances in heterogeneous cases. Copyright © 2015 John Wiley & Sons, Ltd.
Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor (2014)

NF-κB is involved in the immunosuppression induced by human EOC, and its inhibitor may restore antitumour immune responses, indicating that NF-κB is an attractive target for EOC treatment.
Supplementary Data URL from Application of Oligonucleotide Microarrays to Assess the Biological Effects of Neoadjuvant Imatinib Mesylate Treatment for Localized Prostate Cancer (2023)

&lt;p&gt;Website with figures, tables, and raw microarray data&lt;/p&gt;
Comment on "A self-assembled three-dimensional cloak in the visible" in Scientific Reports 3, 2328 (2013)

Mühlig et. al. propose and fabricate a "cloak" comprised of nano-particles on the surface of a sub-wavelength silica sphere. However, the coating only reduces the scattered fields. This is achieved by increased absorption, such that total extinction increases at all wavelengths. An object creating a large shadow is generally not considered to be cloaked; functionally, in contrast to the relatively few structures that can reduce total extinction, there are many that can reduce scattering alone.
An Approach for Improving Execution Performnce in Inference Network Based In (1994)

The inference network retrieval model provides the ability to combine a variety of retrieval strategies expressed in a rich query language. While this power yields impressive retrieval effectiveness, it also presents barriers to the incorporation of traditional optimization techniques intended to improve the execution efficiency, or speed, of retrieval. The essence of these optimization techniques is the ability to identify the indexing information that will be most useful for evaluating a query, combined with the ability to access from disk just that information. I survey a variety of techniques intended to identify useful indexing information and propose a new strategy for incorporating these techniques into the inference network retrieval model. Additionally, I describe an architecture based on a persistent object store that provides sophisticated management of the indexing data, allowing just the desired indexing data to be accessed from disk during retrieval.
ChemInform Abstract: The Photoelectrochemical Oxidation of n‐Si in Anhydrous HF‐Acetonitrile. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Culture Adaptation Alters Transcriptional Hierarchies among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation (2015)

We have used single cell transcriptome analysis to re-examine the substates of early passage, karyotypically Normal, and late passage, karyotypically Abnormal ('Culture Adapted') human embryonic stem cells characterized by differential expression of the cell surface marker antigen, SSEA3. The results confirmed that culture adaptation is associated with alterations to the dynamics of the SSEA3(+) and SSEA3(-) substates of these cells, with SSEA3(-) Adapted cells remaining within the stem cell compartment whereas the SSEA3(-) Normal cells appear to have differentiated. However, the single cell data reveal that these substates are characterized by further heterogeneity that changes on culture adaptation. Notably the Adapted population includes cells with a transcriptome substate suggestive of a shift to a more naïve-like phenotype in contrast to the cells of the Normal population. Further, a subset of the Normal SSEA3(+) cells expresses genes typical of endoderm differentiation, despite also expressing the undifferentiated stem cell genes, POU5F1 (OCT4) and NANOG, whereas such apparently lineage-primed cells are absent from the Adapted population. These results suggest that the selective growth advantage gained by genetically variant, culture adapted human embryonic stem cells may derive in part from a changed substate structure that influences their propensity for differentiation.
ChemInform Abstract: A Hetero Pauson—Khand Reaction of Ketenimines: A New Synthetic Method for γ‐Exomethylene‐α,β‐unsaturated γ‐Lactams. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Progress in Technology of the Chromatographic Columns in HPLC (2022)

Chromatographic column is an essential part of a any HPLC separation, and significant progress has been made in developing columns with better performance to provide better separation, a shorter separation time, resilience to a wider pH range of the mobile phase, longer lifetime, use of lower volumes of mobile phase, etc. All these characteristics were achieved by the introduction of novel technologies and improvements of the older ones. These include smaller particle used to fill the column, more homogeneous spherical particles, core-shell particles, monolithic columns, more pure silica as a stationary phase support, use of ethylene bridge silica, a wider variety of active phases, use of mixed mode stationary phases, use of polymers as stationary phase, use of various endcapping techniques, etc. Miniaturization and progress in the instrumentation played an important role for the chromatographic column development. All these aspects are summarized in the present chapter.