gebhart/patrepeval huggingface dataset:
Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody (2017)

Various studies have demonstrated that Fc engineering to enhance neonatal Fc receptor (FcRn) binding is effective for elongating half-life or increasing cellular uptake of IgG. A previous study has shown that a N434H mutation to enhance FcRn binding resulted in increased binding to rheumatoid factor (RF) autoantibody, which is not desirable for therapeutic use in autoimmune disease. In this study, we first showed that all the existing Fc variants with enhanced FcRn binding also show increased RF binding, and then identified specific mutations that could be introduced to those Fc variants to reduce the RF binding. Furthermore, we generated novel Fc variants that do not increase RF binding and show half-lives of 45 d in cynomolgus monkey, which is longer than those of previously reported Fc variants. In addition, we generated novel Fc variants with antigen sweeping activity that do not increase RF binding. We expect that these novel Fc variants will be useful as antibody therapeutics against autoimmune diseases.
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models (2015)

A series of novel compounds with two halogen substituents have been designed and synthesized to further optimize the 2-phenylcyclopropylmethylamine scaffold in the quest for drug-like 5-HT2C agonists. Compound (+)-22a was identified as a potent 5-HT2C receptor agonist, with good selectivity against the 5-HT2B and the 5-HT2A receptors. ADMET assays showed that compound (+)-22a possessed desirable properties in terms of its microsomal stability, and CYP and hERG inhibition, along with an excellent brain penetration profile. Evaluation of (+)-22a in animal models of schizophrenia-related behaviors revealed that it had a desirable activity profile, as it reduced d-amphetamine-stimulated hyperlocomotion in the open field test, it restored d-amphetamine-disrupted prepulse inhibition, it induced cognitive improvements in the novel object recognition memory test in NR1-KD animals, and it produced very little catalepsy relative to haloperidol. These data support the further development of (+)-22a as a drug candidate for the treatment of schizophrenia.
Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke) (2012)

Worldwide, the aging population, globalization, rapid urbanization,\nand population growth have fundamentally changed disease patterns.\nNoncommunicable diseases (NCDs), of which cardiovascular\ndisease (CVD) accounts for nearly half, have overtaken\ncommunicable diseases as the world’s major disease burden.\nCVD remains the No. 1 global cause of death, accounting for\n17.3 million deaths per year, a number that is expected to grow\nto .23.6 million by 2030. Increasingly, the populations affected\nare those in low- and middle-income countries, where 80% of\nthese deaths occur, usually at younger ages than in higher-income\ncountries, and where the human and financial resources to address\nthem are most limited.1\nThe epidemiological transition occurring is exacerbated by the\nlack of vital investment in sustainable health policies to address\nand curtail the risk factors associated with CVD and NCDs.\nRecognizing the profound mismatch between the need for investment\nin the prevention and control of CVD at the global and national\nlevel and the actual resources allocated, the international\nCVD community, under the umbrella of the World Heart Federation,\njoined the NCD community to call for a United Nations\n(UN) High-level Meeting on Non-communicable Diseases, held\nin September 2011. At this meeting, heads of state signed a Political\nDeclaration that committed governments to the development of 4\nspecific measures to address the NCD burden in a specific\ntimeline: (1) Recommendations for a global monitoring framework\nthat included NCD targets to be completed by the end of\n2012; (2) development of a plan for an effective multisector\npartnership by the end of 2012; (3) national NCD plans by\n2013; and (4) a comprehensive review to evaluate progress, to\ntake place in 2014.2
Provisioning and Operation of Virtual Networks (2024)

In today's Internet, requirements of services regarding the underlying transport network are very diverse. In the future, this diversity will increase and make it harder to accommodate all services in a single network. A possible approach to keep up with this diversity in future networks is the deployment of isolated, custom tailored networks on top of a single shared physical substrate. The COMCON (COntrol and Monitoring of COexisting Networks) project aims to define a reference architecture for setup, control, and monitoring of virtual networks on a provider- and operator-grade level. In this paper, we present the building blocks and interfaces of our architecture.
Randomized routing on fat-tress (1985)

Fat-trees are a class of routing networks for hardwareefficient parallel computation. This paper presents a randomized algorithm for routing messages on a fat-tree. The quality of the algorithm is measured in terms of the load factor of a set of messages to be routed, which is a lower bound on the time required to deliver the messages. We show that if a set of messages has load factor λ = Ω(lg n lg lg n) on a fat-tree with n processors, the number of delivery cycles (routing attempts) that the algorithm requires is O(λ) with probability 1-O(1/n). The best previous bound was O(λ lg n) for the off-line problem where switch settings can be determined in advance. In a VLSI-like model where hardware cost is equated with physical volume, we use the routing algorithm to demonstrate that fat-trees are universal routing networks in the sense that any routing network can be efficiently simulated by a fat-tree of comparable hardware cost.
Multi-beam antenna combining for 28 GHz cellular link improvement in urban environments (2013)

This article demonstrates the performance of multi-beam antenna combining for improving link quality in future millimeter-wave cellular systems. Using experimental data obtained from 28 GHz propagation measurements in New York City [8], we demonstrate how the combination of two, three and four beams, either noncoherently or coherently at the mobile receiver antenna, can improve the propagation link substantially. The results reveal that an average of 28.1 dB improvement in path loss can be achieved via combining the strongest four received signals coherently, when compared to the case of randomly received signals using a single beam at the receiver. This paper is the first to present the potential of multi-beam combining for improving link budget (e.g., extending range) in future mm-wave urban cellular systems.
Novel high performance multispectral photodetector and its performance (2016)

Banpil Photonics has developed a novel high-performance multispectral photodetector array for Short-Wave Infrared (SWIR) imaging. The InGaAs based device uses a unique micro-nano pillar structure that eliminates surface reflection to significantly increase sensitivity and the absorption spectra compared to its macro-scaled thin film pixels counterpart (non-pillar). We discuss the device structure and highlight fabrication of the novel high performance multispectral image sensor. We also present performance results of the device characterization showing low dark current suitable for high performance imaging applications for the most demanding security, defense, and machine vision applications.
Surface-Doped Zinc Gallate Colloidal Nanoparticles Exhibit pH-Dependent Radioluminescence with Enhancement in Acidic Media (2023)

As abnormal acidic pH symbolizes dysfunctions of cells, it is highly desirable to develop pH-sensitive luminescent materials for diagnosing disease and imaging-guided therapy using high-energy radiation. Herein, we explored near-infrared-emitting Cr-doped zinc gallate ZnGa<sub>2</sub>O<sub>4</sub> nanoparticles (NPs) in colloidal solutions with different pH levels under X-ray excitation. Ultrasmall NPs were synthesized via a facile hydrothermal method by controlling the addition of ammonium hydroxide precursor and reaction time, and structural characterization revealed Cr dopants on the surface of NPs. The synthesized NPs exhibited different photoluminescence and radioluminescence mechanisms, confirming the surface distribution of activators. It was observed that the colloidal NPs emit pH-dependent radioluminescence in a linear relationship, and the enhancement reached 4.6-fold when pH = 4 compared with the colloidal NPs in the neutral solution. This observation provides a strategy for developing new biomaterials by engineering activators on the nanoparticle surfaces for potential pH-sensitive imaging and imaging-guided therapy using high-energy radiation.
Optimization of the annealing conditions for thin VO2 ALD films (2012)

Vanadium dioxide (VO2) is an intriguing material due to its semiconductor-metal transition (SMT). During this transition, which occurs near 67°C, electrical as well as optical properties change drastically. Possible applications include thermochromic windows, and memories or switches in micro- and optoelectronics. Although atomic layer deposition (ALD) is gaining importance for some of these applications, the growth of VO2 with this technique is not obvious, since in most cases V2O5 is obtained. In our previous work we presented ALD growth of VO2 by using Tetrakis[EthylMethylAmino]Vanadium and ozone at a temperature of 150°C [1]. XPS revealed the 4+ oxidation state of vanadium, indicating growth of VO2. Post-ALD thermal processing proved essential to crystallize the VO2 in the desired tetragonal phase (R). In this work we present the influence of the oxygen partial pressure on phase formation during such thermal processes. Additionally the influence of film thickness and annealing temperature on the post-annealing properties were studied, including morphology and SMT characteristics. During thermal processing a minimum oxygen partial pressure of approximately 1 Pa is indispensable to form crystalline VO2 (R) (figure 1). Oxygen partial pressures above 2 Pa show an intermediate monoclinic phase (B), which transforms to VO2 (R) at higher temperatures. At a value of 35 Pa this VO2 (B) phase finally transforms to V6O13 instead of VO2 (R). For very thin films, the thermal post-processing may result in agglomeration of the VO2 layers on the SiO2 substrate. Samples with a film thickness above 20nm show a typical resistivity ratio during the SMT of more than 2 orders of magnitude when annealed in the range 450°C to 500°C. For thinner films or higher annealing temperatures the resistivity ratio is suppressed and an overall increased resistivity is observed due to agglomeration (figure 2).
Ionic Liquid-Based Electrolytes for Calcium-Based Energy Storage Systems (2020)

In this work, aprotic and protic ionic liquid (IL)-based electrolytes designed for calcium-based energy storage systems are investigated. We have shown that these electrolytes display good transport properties and electrochemical stabilities comparable with those of IL-based electrolytes proposed for lithium and sodium-based systems. The use of these electrolytes in electrochemical double layer capacitors (EDLCs) leads to the realization of devices displaying good capacitances paired with a high reversibility and stability. Their use in combination with TiS 2 cathode appears more problematic as the cation of the ILs is inserting in the layered structure of this material during the charge process. In this latter case a careful design of the cation appears necessary to guarantee selective insertion of Ca 2+ and reversible charge-discharge process.
An Adaptive Parallel Computer Vision System (1998)

An approach for designing a hybrid parallel system that can perform different levels of parallelism adaptively is presented. An adaptive parallel computer vision system (APVIS) is proposed to attain this goal. The APVIS is constructed by integrating two different types of parallel architectures, i.e. a multiprocessor based system (MBS) and a memory based processor array (MPA), tightly into a single machine. One important feature in the APVIS is that the programming interface to execute data parallel code onto the MPA is the same as the usual subroutine calling mechanism. Thus the existence of the MPA is transparent to the programmers. This research is to design an underlying base architecture that can be optimally executed for a broad range of vision tasks. A performance model is provided to show the effectiveness of the APVIS. It turns out that the proposed APVIS can provide significant performance improvement and cost effectiveness for highly parallel applications having a mixed set of parallelisms. Also an example application composed of a series of vision algorithms, from low-level and medium-level processing steps, is mapped onto the MPA. Consequently, the APVIS with a few or tens of MPA modules can perform the chosen example application in real time when multiple images are incoming successively with a few seconds inter-arrival time.
QCDOC: A 10 Teraflops Computer for Tightly-Coupled Calculations (2005)

Numerical simulations of the strong nuclear force, known as quantum chromodynamics or QCD, have proven to be a demanding, forefront problem in high-performance computing. In this report, we describe a new computer, QCDOC (QCD On a Chip), designed for optimal price/performance in the study of QCD. QCDOC uses a six-dimensional, low-latency mesh network to connect processing nodes, each of which includes a single custom ASIC, designed by our collaboration and built by IBM, plus DDR SDRAM. Each node has a peak speed of 1Gigaflops and two 12,288node, 10+ Teraflops machines are to be completed in the fall of 2004. Currently, a 512 node machine is running, delivering efficiencies as high as 45% of peak on the conjugate gradient solvers that dominate our calculations and a 4096-node machine with a cost of $1.6M is under construction. This should give us a price/performance less than $1per sustained Megaflops.
Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays (2023)

Affinity-based biosensing can enable point-of-care diagnostics and continuous health monitoring, which commonly follows bottom-up approaches and is inherently constrained by bioprobes' intrinsic properties, batch-to-batch consistency, and stability in biofluids. We present a biomimetic top-down platform to circumvent such difficulties by combining a "dual-monolayer" biorecognition construct with graphene-based field-effect-transistor arrays. The construct adopts redesigned water-soluble membrane receptors as specific sensing units, positioned by two-dimensional crystalline S-layer proteins as dense antifouling linkers guiding their orientations. Hundreds of transistors provide statistical significance from transduced signals. System feasibility was demonstrated with rSbpA-ZZ/CXCR4<sup>QTY</sup>-Fc combination. Nature-like specific interactions were achieved toward CXCL12 ligand and HIV coat glycoprotein in physiologically relevant concentrations, without notable sensitivity loss in 100% human serum. The construct is regeneratable by acidic buffer, allowing device reuse and functional tuning. The modular and generalizable architecture behaves similarly to natural systems but gives electrical outputs, which enables fabrication of multiplex sensors with tailored receptor panels for designated diagnostic purposes.
Thermal evaluation of a medium frequency transformer in a line side conversion system (2009)

A central part of a medium frequency conversion system is the transformer. A medium frequency transformer for railway propulsion may be stressed beyond 30kV with voltage slopes around 50kV/µs depending on topology while the geometric dimensions are small. A 170kVA transformer prototype operated at 4kHz has been developed and tested. A transient thermal model of the transformer is developed and verified experimentally. The transient thermal behavior is important in propulsion applications where the conversion system is often heavily overloaded. Simulations indicate that the overloading capability of the transformer is comparable to a conventional traction transformer. Experimental results are in good agreement with the model.
272. Rapid Identification of Tumor- and Neoantigen-Reactive T-Cell Receptors for Personalized Immunotherapy (2016)

Adoptive transfer of T-cell receptor (TCR) gene engineered T-cells targeting tumor-associated antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success of many immunotherapies is mediated by T-cells targeting mutated neoantigens unique to the patient. We hypothesized that the most frequent TCR clonotypes infiltrating the tumor were reactive against tumor antigens. We thus developed a multi-step strategy that involved CDR3-TCRB deep sequencing of tumor infiltrating lymphocytes and matching of TCRA-TCRB pairs by pairSEQ and single cell RT-PCR. CDR3 TCRA-TCRB pairs identified with this approach, were then reconstructed to full length based on IMGT database [http://www.imgt.org], synthetized and cloned into non-viral and retroviral expression vectors. T-cells were gene-engineered with these TCRs and tested against tumor cell lines and antigen presenting cells expressing tandem minigenes encoding mutated tumor neoantigens and/or pulsed with corresponding mutated peptides. Analysis of 12 fresh metastatic melanomas revealed that in 11 samples, up to 5 tumor-reactive TCRs were present in the 5 most frequently occurring clonotypes including reactivity against neoantigens. These data demonstrate the feasibility of developing a rapid approach for the identification of tumor-reactive TCRs that can be used for personalized TCR-gene therapy.
Preferential interaction of the Alzheimer peptide Aβ‐(1–42) with Omega‐3‐containing lipid bilayers: structure and interaction studies (2016)

Many age-related neurodegenerative diseases, including Alzheimer Disease (AD), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega-3 phospholipids seems to reduce the AD incidence. To investigate the molecular basis of this beneficial effect, we have investigated by CD and ESR studies the interaction between the Alzheimer peptide Aβ-(1-42) and biomimetic lipid bilayers. The inclusion of 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine does not change significantly the bilayers organization, but favors its Aβ-(1-42) interaction. The Omega-3 lipid amount modulates the effect intensity, suggesting a peptide selectivity for membranes containing polyunsatured fatty acids (PUFA) and providing hints for the mechanism and therapy of AD.
Increased leukocyte adhesiveness/aggregation is the single best biochemical indicator of disease activity in adolescent patients with inflammatory bowel disease. (1996)

We determined the relative utility of inflammatory markers in evaluating disease activity in adolescent patients with inflammatory bowel disease (IBD). Sixty-one adolescent patients and 50 age and sex matched volunteers who served as controls were evaluated prospectively. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell count (WBCC), and the leukocyte adhesiveness/aggregation (LAA) test were determined in each patient. There were 28 subjects in remission and 33 in relapse. Their percentage of aggregated white blood cells in the peripheral blood was 7 +/- 5 and 16 +/- 8, respectively, when compared with the control group (5 +/- 3) (p < 0.0001). Moreover, the LAA test was the only one which could effectively classify patients with IBD into their correct diagnostic categories of remission, mild-moderate, or moderate-severe disease activity. The LAA test is superior to other acute phase reactants used in daily practice to detect the presence of inflammation as well as for the assessment of its severity in adolescent patients with IBD. In addition, our findings may have biological relevance to the disease process and its potential manipulation by anti-adhesive agents.
Spatial encoding circuit techniques for peak power reduction of on-chip high-performance buses (2004)

We propose various low-latency spatial encoder circuits based on bus-invert coding for reducing peak energy and current in on-chip buses with minimum penalty on total latency. The encoders are implemented in dual-rail domino logic with interfaces for static inputs and static buses. A spatial and temporally encoded dynamic bus technique is also proposed for higher performance targets. Comparisons to standard on-chip buses of various lengths with optimal repeater configurations at the 130nm node show the energy-delay and peak current-delay design space in which the different encoder circuits are beneficial. A 9mm spatially encoded static bus exhibits peak energy gains beyond that achievable through repeater optimization for a single cycle operation at 1GHz, with delay and energy overhead of the encoding included. For throughput constrained buses, the spatially encoded static bus can provide up to 31% reduction in peak energy, while the spatially and temporally encoded dynamic bus yields peak current reductions of more than 50% for all bus lengths.
Gold Nanoparticles: A Revival in Precious Metal Administration to Patients (2011)

Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis, and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods while concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, the present review summarizes the chemistry, pharmacokinetics, biodistribution, metabolism, and toxicity of bulk gold in humans based on decades of clinical observation and experiments in which gold was used to treat patients with rheumatoid arthritis. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, functionalization, and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed.
FlexEthernet Eutoriai (2016)

•Enable flexibility on Ethernet interface: Custom rates Efficient LAG Match transport bandwidth Unbounded MLG Channelization Increase interface reliability Break Ethernet and transport roadmap marriage •Ready to be adopted on 100GE interface Faster Ethernet rates added in future versions.
FINGERPRINTING OF GRAPE CULTIVARS GROWN IN CHILE : COMPARISON OF METHODS BASED ON ANONYMOUS SEQUENCES AND A SET OF MICROSATELLITE LOCI (2000)

ISHS VII International Symposium on Grapevine Genetics and Breeding FINGERPRINTING OF GRAPE CULTIVARS GROWN IN CHILE : COMPARISON OF METHODS BASED ON ANONYMOUS SEQUENCES AND A SET OF MICROSATELLITE LOCI
Validation of ctDNA Quality Control Materials Through a Precompetitive Collaboration of the Foundation for the National Institutes of Health (2021)

These results support the utility of the QCM in testing ctDNA assay analytical performance. However, unique designs and manufacturing methods for the QCM, and variations in a laboratory's testing configuration, may require testing of multiple QCMs to find the best reagents for accurate result interpretation.