gebhart/patrepeval huggingface dataset:
Product quality and plant build complexity (2009)

Abstract This paper assesses the hypothesis that plant build complexity impacts quality, suggests mechanisms to explain how complexity impacts quality, and offers countermeasures to mitigate this impact. We analyse automotive assembly data that supports the proposition that plant build complexity negatively impacts quality. In addition, this paper provides actual automotive assembly line work instructions and shows how they can be represented by the Gilbreths’ fundamental work elements and plant build complexity impacts these work elements. To highlight complexity's adverse impact on quality, we compare the actual work instructions at two automotive assembly line stations–one with very little complexity and one with extreme complexity. We list common automotive assembly quality lapses and describe how they can be caused or exacerbated by complexity. Finally the paper presents practical countermeasures to mitigate complexity's impact on quality. While based on the automotive industry, the lessons apply to all complex assembly lines. Keywords: automotiveassembly lineproduct varietyflexible manufacturing Acknowledgements We thank Sam Marin and Ron Scholl of General Motors Corporation for their insight and suggestions. We also thank two anonymous reviewers for their insightful and constructive comments.
The brain on low power architectures: Efficient simulation of cortical slow waves and asynchronous states (2018)

Efficient brain simulation is a scientific grand challenge, a parallel/distributed coding challenge and a source of requirements and suggestions for future computing architectures. Indeed, the human brain includes about 1015 synapses and 1011 neurons activated at a mean rate of several Hz. Full brain simulation poses Exascale challenges even if simulated at the highest abstract level. Te WaveScalES experiment in the Human Brain Project (HBP) has the goal of matching experimental measures and simulations of slow waves during deep-sleep and anaesthesia and the transition to other brain states. The focus is the development of dedicated large-scale parallel/distributed simulation technologies. The ExaNeSt project designs and ARM-based, low power HPC architecture scalable to million of corses, developing a dedicated scalable interconnect system, and SWA/AW simulations are included among the driving benchmarks. At the joint between both projects is the iNFN proprietary Distributed and Plastic Spiking Neural Networks (DPSNN) simulation engine. DPSNN can be configured to stress either the networking or the computation features available on the execution platforms. The simulation stresses the networking component when the neural net - composed by a relatively low number of neurons, each one projecting thousands of synapses - is distributed over a large number of hardware cores. When growing the number of neurons per core, the computation starts to be the dominating component for short range connections. This paper reports about preliminary performance results obtained on an ARM-based HPC prototype developed in the framework of the ExaNeSt project. Furthermore, a comparison is given of instantaneous power, total energy consumption, execution time and energetic cost per synaptic event of SWA/AW DPSNN simulations when executed on either ARM- or Intel-based server platforms.
Report on the online session on visions, requirements and needs for Future Research Environments in the Healthcare domain (2020)

The European Open Science Cloud (EOSC) initiative aims at supporting more than 1.7 million researchers and fostering interdisciplinary research in Europe. To understand better, what the research community needs, the EOSCSecretariat [1] partner TU Wien is organizing workshops, interviews and consultations. As part of this initiative, the EOSCSecretariat invited a group of three top-level researchers and research enablers from the Healthcare domain to online sessions in June 2020 on visions, requirements and needs to inquire not only about their actual needs with respect to research infrastructures, services and policies, but also about visions and future needs and requirements. [1] See https://www.eoscsecretariat.eu/
Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates (2015)

To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
Named Entity Recognition with stack residual LSTM and trainable bias decoding (2017)

Recurrent Neural Network models are the state-of-the-art for Named Entity Recognition (NER). We present two innovations to improve the performance of these models. The first innovation is the introduction of residual connections between the Stacked Recurrent Neural Network model to address the degradation problem of deep neural networks. The second innovation is a bias decoding mechanism that allows the trained system to adapt to non-differentiable and externally computed objectives, such as the entity-based F-measure. Our work improves the state-of-the-art results for both Spanish and English languages on the standard train/development/test split of the CoNLL 2003 Shared Task NER dataset.
Closed-loop feedback control of microbubble diameter from a flow-focusing microfluidic device (2020)

Real-time observation and control of particle size and production rate in microfluidic devices are important capabilities for a number of applications, including the production, sorting, and manipulation of microbubbles and droplets. The production of microbubbles from flow-focusing microfluidic devices had been investigated in multiple studies, but each lacked an approach for on-chip measurement and control of microbubble diameter in real time. In this work, we implement a closed-loop feedback control system in a flow-focusing microfluidic device with integrated on-chip electrodes. Using our system, we measure and count microbubbles between 13 and 28 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>μ</mml:mi></mml:math> m in diameter and control their diameter using a proportional-integral controller. We validate our measurements against an optical benchmark with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mi>R</mml:mi> <mml:mn>2</mml:mn></mml:msup> <mml:mo>=</mml:mo> <mml:mn>0.98</mml:mn></mml:math> and achieve a maximum production rate of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mn>1.4</mml:mn> <mml:mo>×</mml:mo> <mml:msup><mml:mn>10</mml:mn> <mml:mn>5</mml:mn></mml:msup> </mml:math> /s. Using the feedback control system, the device enabled control in microbubble diameter over the range of 14-24 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>μ</mml:mi></mml:math> m.
Supplementary Table 2 from Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer (2023)

&lt;p&gt;PDF file - 45K, Table S2. Adverse events observed in the clinical trial.&lt;/p&gt;
Patterning non-equilibrium morphologies in stimuli-responsive gels through topographical confinement (2019)

Stimuli-responsive "smart" polymers have generated significant interest for introducing dynamic control into the properties of antifouling coatings, smart membranes, switchable adhesives and cell manipulation substrates. Switchable surface morphologies formed by confining stimuli-responsive gels to topographically structured substrates have shown potential for a variety of interfacial applications. Beyond patterning the equilibrium swelling behavior of gels, subjecting stimuli-responsive gels to topographical confinement could also introduce spatial gradients in the various timescales associated with gel deformation, giving rise to novel non-equilibrium morphologies. Here we show how by curing poly(N-isopropylacrylamide) (pNIPAAm)-based gel under confinement to a rigid, bumpy substrate, we can not only induce the surface curvature to invert with temperature, but also program the transient, non-equilibrium morphologies that emerge during the inversion process through changing the heating path. Finite element simulations show that the emergence of these transient morphologies is correlated with confinement-induced gradients in polymer concentration and position-dependent hydrostatic pressure within the gel. To illustrate the relevance of such morphologies in interfacial applications, we show how they enable us to control the gravity-induced assembly of colloidal particles and microalgae. Finally, we show how more complex arrangements in particle assembly can be created through controlling the thickness of the temperature-responsive gel over the bumps. Patterning stimuli-responsive gels on topographically-structured surfaces not only enables switching between two invertible topographies, but could also create opportunities for stimuli ramp-dependent control over the local curvature of the surface and emergence of unique transient morphologies. Harnessing these features could have potential in the design of multifunctional, actuatable materials for switchable adhesion, antifouling, cell manipulation, and liquid and particle transport surfaces.
Analysis of aminophospholipid molecular species by methyl-β-cyclodextrin modified micellar electrokinetic capillary chromatography with laser-induced fluorescence detection (2002)

Micellar electrokinetic capillary chromatography (MEKC) with laser-induced fluorescence detection is used for the analysis of three classes of aminophospholipids: phosphatidylethanolamine (PE), phosphatidylserine (PS), and lysophosphatidylethanolamine (LPE) molecular species. 3-(2-Furoyl) quinoline-2-carboxaldehyde (FQ), a fluorogenic dye, was employed for labeling of these phospholipids. The FQ-labeled lipid species were then separated by sodium deoxycholate MEKC modified with methyl-beta-cyclodextrin. Baseline resolution of each class of phospholipids was achieved within 7 min. The migration time in each class increased with the carbon number of their side aliphatic chain. Separation efficiencies of approximately 3x10(5) plates were observed for most of these species. Concentration detection limits (3 sigma) were from 10(-9) to 10(-10) M for PE and LPE species and from 10(-8) to 10(-9) M for PS species. The relative standard deviations for migration time and peak area were less than 0.9% and 4.5%, respectively, for seven PE species. This method was applied to the separation of PE isolated from HT29 human colon cancer cells and roughly 30 PE species were resolved.
A syndrome of asymmetric limb weakness with motor conduction block (1990)

We describe 3 patients with asymmetric limb weakness, fasciculations (2 patients), relatively preserved reflexes, normal cranial nerves, and few or no sensory abnormalities. The symptoms had been progressive over 1 to 15 years. Detailed motor nerve conduction studies showed conduction block and slowing localized to sharply circumscribed areas 30 to 100 mm long in several nerves in each patient. By contrast, the sensory conduction studies over the same nerve segments were normal, indicating very selective involvement of motor fibers. Sural nerve biopsies showed minor changes that varied among the patients. One patient had high levels of anti-GM1 antibodies, 1 had mildly elevated levels, and 1 had high levels of only asialo-GM1 antibodies. Treatment with immune suppressive therapy has produced minimal improvement in 1 patient.
Free-space optical platform design consideration for all-optical TDM switch array (2002)

For ultra-fast multiplexing and demultiplexing, an all-optical switch module using free-space platform with diffractive optical elements is a promising approach. This paper discusses design considerations in terms of robustness, efficiency and compactness.
Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett’s esophagus neoplasia with histopathology correlation (2020)

Volumetric laser endomicroscopy (VLE) has been shown to improve detection of early neoplasia in Barrett's esophagus (BE). However, diagnostic performance using histopathology-correlated VLE regions of interest (ROIs) has not been adequately studied. We evaluated the diagnostic accuracy of VLE assessors for identification of early BE neoplasia in histopathology-correlated VLE ROIs. In total, 191 ROIs (120 nondysplastic and 71 neoplastic) from 50 BE patients were evaluated in a random order using a web-based module. All ROIs contained histopathology correlations enabled by VLE laser marking. Assessors were blinded to endoscopic BE images and histology. ROIs were first scored as nondysplastic or neoplastic. Level of confidence was assigned to the predicted diagnosis. Outcome measures were: (i) diagnostic performance of VLE assessors for identification of BE neoplasia in all VLE ROIs, defined as accuracy, sensitivity, and specificity; (ii) diagnostic performance of VLE assessors for only high level of confidence predictions; and (iii) interobserver agreement. Accuracy, sensitivity, and specificity for BE neoplasia identification were 79% (confidence interval [CI], 75-83), 75% (CI, 71-79), and 81% (CI, 76-86), respectively. When neoplasia was identified with a high level of confidence, accuracy, sensitivity, and specificity were 88%, 83%, and 90%, respectively. The overall strength of interobserver agreement was fair (k = 0.29). VLE assessors can identify BE neoplasia with reasonable diagnostic accuracy in histopathology-correlated VLE ROIs, and accuracy is enhanced when BE neoplasia is identified with high level of confidence. Future work should focus on renewed VLE image reviewing criteria and real-time automatic assessment of VLE scans.
Reversal of α1‐receptor mediated relaxation in intestinal smooth muscle (1981)

The alpha 1-receptor agonist phenylephrine relaxed longitudinal rabbit jejunal muscle contracted in vitro by low concentrations of barium ions (1 mM). When the Ba2+ concentration was increased to 10-15 mM the response to phenylephrine was a contraction, and at Ba2+ concentrations in between the high and low range this response was biphasic--a relaxation followed by a contractile phase. The alpha 2-receptor agonist clonidine did not affect the tone of the Ba2+ contracted preparation. When the muscle preparation was contracted by Sr2+ (1-20 mM) in the presence of Ca2+ (2.5 mM), phenylephrine relaxed it, and no contractile response to phenylephrine was observed. In the absence of extracellular Ca2+, 5 mM Ba2+ caused a contraction. Under these conditions phenylephrine had no effect on the tissue tone. When Ca2+ was added in a low concentration (0.2-2 mM), phenylephrine elicited a gradually increasing contractile response. At 5 mM Ca2+ the contractile response was replaced by the normal relaxation. The contractile response to phenylephrine in the presence of 5 mM Ba2+ and 2.5 mM Ca2+ was partially blocked by low concentrations of verapamil. In higher concentrations verapamil abolished the tissue tonus completely. The contractile response to phenylephrine in the presence of 5 mM Ba2+ and 2.5 mM Ca2+ could be reverted to the normal relaxation by the addition of 20 mM Mg2+. Increasing the K+ concentration from the normal 5.9 to 62.9 mM blocked the phenylephrine-induced relaxation. No contractile response to phenylephrine occurred. It is concluded that Ba2+ could reverse the response of alpha 1 receptor stimulation in rabbit jejunum from a relaxation to a contraction and that this contractile response was dependent on the presence of Ca2+.
150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer (2007)

You have accessJournal of UrologyModerated Poster 6, Sunday, May 20, 2007, 8:00 - 10:00 am1 Apr 2007150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer Shintaro Narita, Alan I. So, Shannon Sinnemann, Ladan Fazli, Eric G. Marcusson, and Martin E. Gleave Shintaro NaritaShintaro Narita More articles by this author , Alan I. SoAlan I. So More articles by this author , Shannon SinnemannShannon Sinnemann More articles by this author , Ladan FazliLadan Fazli More articles by this author , Eric G. MarcussonEric G. Marcusson More articles by this author , and Martin E. GleaveMartin E. Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30415-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer." The Journal of Urology, 177(4S), p. 51 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 51 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Shintaro Narita More articles by this author Alan I. So More articles by this author Shannon Sinnemann More articles by this author Ladan Fazli More articles by this author Eric G. Marcusson More articles by this author Martin E. Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis (2005)

Synaptotagmins (syts) are a family of membrane proteins present on a variety of intracellular organelles. In vertebrates, 16 isoforms of syt have been identified. The most abundant isoform, syt I, appears to function as a Ca2+ sensor that triggers the rapid exocytosis of synaptic vesicles from neurons. The functions of the remaining syt isoforms are less well understood. The cytoplasmic domain of syt I binds membranes in response to Ca2+, and this interaction has been proposed to play a key role in secretion. Here, we tested the Ca(2+)-triggered membrane-binding activity of the cytoplasmic domains of syts I-XII; eight isoforms tightly bound to liposomes that contained phosphatidylserine as a function of the concentration of Ca2+. We then compared the disassembly kinetics of Ca2+.syt.membrane complexes upon rapid mixing with excess Ca2+ chelator and found that syts can be classified into three distinct kinetic groups. syts I, II, and III constitute the fast group; syts V, VI, IX, and X make up the medium group; and syt VII exhibits the slowest kinetics of disassembly. Thus, isoforms of syt, which have much slower disassembly kinetics than does syt I, might function as Ca2+ sensors for asynchronous release, which occurs after Ca2+ domains have collapsed. We also compared the temperature dependence of Ca2+.syt.membrane assembly and disassembly reactions by using squid and rat syt I. These results indicate that syts have diverged to release Ca2+ and membranes with distinct kinetics.
Graph representations of frequency duplexing used for interference elimination (2016)

Interference elimination is a key aspect of planning and operating wireless networks. Using frequency duplex links is a common practice, where the communication is done via two channels separated in frequency. An optimization problem is how to allocate the channels in the frequency duplex in order to reduce or completely eliminate the interference might occur between links. In a previous paper we revealed the unexpected difference between this problem and polarization setting if the sharpness of the applied beam widths is relaxed in such microwave networks. In this paper we extend the graph theory based approach of this problem and generalize the special cases of the previous study.
FutureGRID: A Program for long-term research into GRID systems architecture (2008)

Proceedings of the 2003 UK e-Science All Hands Meeting, 31st August - 3rd September, Nottingham UK
The Principle and Images of Phase-Contrast Mammography (2006)

The technology of phase-contrast mammography is described from its principle through application to digital mammography. An edge effect due to phase contrast has been formulated with geometric optics for phase-contrast imaging with use of current medical x-ray tubes. The spatial resolutio ni n digital mammography is discussed for design of a phase- contrast digital mammography system. Our empirical study of increase in image-sharpness due to magnification and phase- contrast is reported for each full-field and spot-compression mammography using phase-contrast technology. And experimental results of image noise are also reported in terms of noise power spectra(NPS)for conventional contact and phase-contrast images.
Analytic derivation of electrostrictive tensors and their application to optical force density calculations (2015)

A theoretical formalism is developed to calculate the optical force induced within a 2D metamaterial, based on the electrostrictive tensor. It turns out that it is not always straightforward to use the usual effective-medium parameters $ϵ$ and $\ensuremath{\mu}$ of the metamaterial for obtaining the body force density. The findings are tested via a 2D array of parallel infinitely long dielectric cylinders and the analytical theory is in excellent agreement with numerics. The correct stress tensor to describe the force density in an effective medium is the Helmholtz one rather than the Maxwell. The theory, though, is not exact and points to a fundamental limitation of effective medium theory in describing light-induced body forces.
Integrated process offers lower gas-to-gasoline investment (1986)

Many natural gas fields are in remote locations and of a size which cannot justify construction of a pipeline or liquified natural gas (LNG) plant. In these situations, the natural gas price can be low and the manufacture of gasoline an attractive alternative to producing ammonia or other petro-chemicals. Haldor Topsoe A/S has developed an integrated process scheme to convert natural-gas-derived synthesis gas to gasoline in a single loop. The process, Topsoe integrated gasoline synthesis (Tigas), incorporates Mobil's methanol-to-gasoline (MTG) process. The first step is a synthesis of oxygenates. The second step is the MTG process run at conditions selected to achieve optimum operation of the integrated loop. An industrial pilot plant has been in operation since January 1984. The plant has been running successfully, with long catalyst life, producing high-octane gasoline.
Supplementary Figure 3 from A Tricin Derivative from <i>Deschampsia antarctica</i> Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response (2023)

&lt;p&gt;Toxicology analysis. Liver transaminases aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured after Antartina{trade mark, serif} treatment and H&amp;E stained tissues from BALB/c mice untreated (n= 5) or treated with 5 mg/kg (n=5) and 50 mg/kg (n=5) of Antartina{trade mark, serif}&lt;/p&gt;