gebhart/patrepeval huggingface dataset:
Modulation of Chondrocytic Properties of Fat-Derived Mesenchymal Cells in Co-Cultures with Nucleus Pulposus (2005)

Human subcutaneous fat-derived mesenchymal cells recently have been shown to have the potential to differentiate in vitro into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, and myoblasts. This effect suggests that fat tissue may serve as an abundant and easily acquired source of multipotent cells for tissue engineering. The multipotential characteristics of fat-derived mesenchymal cells from the inguinial fat pad of rabbit have not been clearly defined. In this study we have isolated a population of mesenchymal cells from inguinal fat from adult New Zealand white rabbits. The cells that were maintained under various differentiation conditions were shown to differentiate in vitro into adipocytes, osteoblasts, or chondrocytes; this differentiation was demonstrated using gene expression for tissue-specific proteins. We also co-cultured the cells with intervertebral disk tissue from the nucleus pulpous or from the annulus fibrosus. The fat-derived cells co-cultured with nucleus pulposus showed an increase in expression of type II collagen and aggrecan genes, compared with cells in alginate alone and cells co-cultured with annulus fibrosus. The data suggest that the fat-derived mesenchymal cells responded to soluble mediators from the disk. Future studies on intervertebral disk reconstruction could be based on our findings with fat-derived multipotential cells from the inguinal region of the rabbit that were co-cultured with disk tissue and may prove useful in tissue engineering strategies.
Switchable optical phased prism arrays for beam steering (2004)

The Wollaston prism with large deflection angle usually has small cross section size, which constrains its application in beam steering. This paper investigates the possibility of assembling the prisms together to increase the cross section size. Single-layer- and double-layer- assembled Wollaston prisms are investigated. The compression ratio and transmission ratio associated with the diffraction efficiency of assembled prisms are calculated and formulated.
Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography (2017)

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co- and by-products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual-mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.
ChemInform Abstract: Synthesis of 5‐Phenylcytosine Nucleoside Derivatives. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TrimBot2020: an outdoor robot for automatic gardening (2018)

Robots are increasingly present in modern industry and also in everyday life. Their applications range from health-related situations, for assistance to elderly people or in surgical operations, to automatic and driver-less vehicles (on wheels or flying) or for driving assistance. Recently, an interest towards robotics applied in agriculture and gardening has arisen, with applications to automatic seeding and cropping or to plant disease control, etc. Autonomous lawn mowers are succesful market applications of gardening robotics. In this paper, we present a novel robot that is developed within the TrimBot2020 project, funded by the EU H2020 program. The project aims at prototyping the first outdoor robot for automatic bush trimming and rose pruning.
Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. (1991)

Renal cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 which suggests the presence of a tumor suppressor gene at this location. In order to more precisely define the location of the renal cell carcinoma gene and to differentiate molecular changes occurring in early stages of renal neoplasia versus those occurring later in malignant progression, DNA from normal and tumor tissue from 60 patients with various stages of renal cell carcinoma was analyzed for loss of alleles at different chromosomal loci. In tumor tissue from 51 of 58 evaluable patients (88%) there was loss of heterozygosity at one or more of 10 loci tested on chromosome 3 independently of tumor stage. Analysis of the genotypes identified the distal portion of 3p bounded by D3S2 and D3S22 (3p21-26) as the region of the disease gene. In tumor tissue from patients with advanced renal cell carcinoma, we found loss of heterozygosity on chromosome 11p in 5 of 21 (24%), on chromosome 13 in 3 of 9 (33%), and on chromosome 17 in 2 of 19 (11%). We found no loss of heterozygosity at the loci on chromosomes 11, 13, or 17 in tumor tissue from patients with localized renal cell carcinoma (N = 5). These data suggest the existence of a tumor suppressor gene on chromosome 3p which may be essential to the genesis of sporadic renal cell carcinoma and that other tumor suppressor genes are associated with progression of this malignancy.
Detecting ammonia and methane with antimonide lasers (2006)

Type I antimonide diode lasers operate in the 2000 to 2800 nm spectral region. Compared to the 1300 to 1650nm communications spectral band, the antimonide band can access stronger molecular transitions and thus potentially achieve higher sensitivity. Compared to quantum cascade or lead-salt lasers operating at longer infrared wavelengths,antimonide lasers have the advantage that both laser and detector technology support room temperature, cw operation. This paper describes experiments to measure ammonia and methane simultaneously, with high sensitivity and fast response, using a distributed feedback laser at 2200 nm. Our approach is based on scanning the laser over a small spectral regionthat encompasses several lines, either by varying the laser temperature or current, while simultaneously using wavelength modulation with harmonic detection to record the spectrum. Temperature scanning is slower but can cover a wider spectral interval. Digital signal processing methods, including classical least squares and singular value decomposition, extract the gas concentrations from the measured spectra. The accuracy and precision of these algorithms are compared in two limits: the limit when both gases are absent or present only at low levels, and the limit when the concentration of one gas is high.
Non-Symmetric Multi-Antenna Coded Caching for Location-Dependent Content Delivery (2022)

Immersive viewing, as the next-generation interface for human-computer interaction, is emerging as a wireless application. A genuinely wireless immersive experience necessitates immense data delivery with ultra-low latency, raising stringent requirements for future wireless networks. In this regard, efficient usage of in-device storage and computation capabilities is a potential candidate for addressing these requirements. In addition, recent advancement in multi-antenna transmission has significantly enhanced wireless communication. Hence, this paper proposes a novel location-based multi-antenna coded cache placement and delivery scheme. We first formulate a linear programming cache allocation problem to provide a uniform quality of experience in different network locations; then, cache-placement is done for each location independently. Subsequently, based on the users’ spatial realizations, a transmission vector is created considering diverse available memory at each user. Moreover, a weighted-max-min optimization is used for the beamformers to support different transmission rates. Finally, numerical results are used to show the performance of the proposed scheme.
Mechanism of Date Retention Improvement by High Temperature Annealing of Al2O3 Blocking Layer in Flash Memory Device (2011)

The mechanism underlying improved data retention via high-temperature oxygen annealing of the Al 2 O 3 blocking layer in a charge-trap type flash memory device is investigated in comparison with the case of high-temperature nitrogen annealing. The results show that significant improvement of the retention property can be achieved by oxygen annealing at 1100 °C, compared to nitrogen annealing. Experimental evidence indicated that the underlying mechanism does not arise from suppression of the trap-assisted tunneling current through the blocking oxide; instead it is caused by a reduction of the thermionic emission component of the charge loss factor. This is possibly due to changes of the conduction band offset of the crystallized Al 2 O 3 .
Opsonization of Actinobacillus actinomycetemcomitans by Immunoglobulin G Antibody Reactive with Phosphorylcholine (2002)

We used two strains of Actinobacillus actinomycetemcomitans, one bearing phosphorylcholine (PC) (strain D045D-40) and one devoid of PC antigens (strain DB03A-42), as well as a nonencapsulated strain of Streptococcus pneumoniae (strain 39937), to examine the opsonic properties of physiological concentrations (</=30 micro g/ml) of purified human anti-PC immunoglobulin G (IgG). Anti-PC bound to both A. actinomycetemcomitans DO45D-40 and S. pneumoniae 39937 and induced superoxide anion production by polymorphonuclear neutrophils; induction of the oxidative burst was inhibited by antibodies to either CD16 or CD32. Thus, anti-PC IgG at concentrations present in most human sera promotes the opsonization of PC-expressing strains of A. actinomycetemcomitans in the absence of complement, implying that anti-PC may be a protective antibody against such strains of bacteria.
Modeling and measurement of fault-tolerant multiprocessors (1985)

The workload effects on computer performance are addressed first for a highly reliable unibus multiprocessor used in real-time control. As an approach to studing these effects, a modified Stochastic Petri Net (SPN) is used to describe the synchronous operation of the multiprocessor system. From this model the vital components affecting performance can be determined. However, because of the complexity in solving the modified SPN, a simpler model, i.e., a closed priority queuing network, is constructed that represents the same critical aspects. The use of this model for a specific application requires the partitioning of the workload into job classes. It is shown that the steady state solution of the queuing model directly produces useful results. The use of this model in evaluating an existing system, the Fault Tolerant Multiprocessor (FTMP) at the NASA AIRLAB, is outlined with some experimental results. Also addressed is the technique of measuring fault latency, an important microscopic system parameter. Most related works have assumed no or a negligible fault latency and then performed approximate analyses. To eliminate this deficiency, a new methodology for indirectly measuring fault latency is presented.
Joint Satellite Gateway Placement and Routing for Integrated Satellite-Terrestrial Networks (2020)

With the increasing attention to the integrated satellite-terrestrial networks (ISTNs), the satellite gateway placement problem becomes of paramount importance. The resulting network performance may vary depending on the different design strategies. In this paper a joint satellite gateway placement and routing strategy for the terrestrial network is proposed to minimize the overall cost of gateway deployment and traffic routing, while adhering to the average delay requirement for traffic demands. Although traffic routing and gateway placement can be solved independently, the dependence between the routing decisions for different demands makes it more realistic to solve an aggregated model instead. We develop a mixed integer linear program (MILP) formulation for the problem. We relax the integrality constraints to achieve a linear program (LP) which reduces time-complexity at the expense of a sub-optimal solution. We further propose a variant of the proposed model to balance the load between the selected gateways.
Overview of methodologies and statistical strategies in observational studies and meta-analyses on the risk of hepatocellular carcinoma in patients with chronic hepatitis B on entecavir or tenofovir therapy (2022)

Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are first-line antiviral therapies for patients with chronic hepatitis B (CHB) and reduce the risk of disease progression and liver-related complications, as well as improve survival by effectively suppressing viral replication. Nevertheless, since the first publication in 2019 on a lower risk of hepatocellular carcinoma (HCC) in Korean patients receiving TDF than those receiving ETV, the topic has remained a hot and unsettled debate. Multiple studies and meta-analyses have yielded conflicting results. As HCC takes time to develop, studies are mainly observational to benefit from a larger sample size and longer follow-up that provides a higher statistical power to compare the two treatments. However, TDF was available to CHB patients a few years later than ETV in most countries, thus leading to a difference in follow-up duration. Moreover, despite studying the same topic, the difference in data sources and available parameters, inclusion and exclusion criteria, and use of statistical methods complicated the interpretation and comparison of the findings and contributed to between-study heterogeneity in meta-analyses. This review describes some caveats in interpreting and comparing the results from these observational studies and meta-analyses. Future studies should explore better designed observational studies with high-quality data sources, and aggregation of patient data in meta-analysis to tackle between-study heterogeneity.
High-Performance Photonic Integrated Circuits on Silicon (2019)

Heterogeneous integration of III–V semiconductor photonics combined with silicon foundry technology enables low-cost, high-performance photonic integrated circuits. Highly reliable lasers using epitaxial deposition of quantum dot lasers, with <2 mA threshold and lifetime >>100 years at 35 C have been demonstrated at University of California, Santa Barbara (UCSB) and can be manufactured at wafer scale. Reduction in the linewidth enhancement factor allows isolator-free operation. This technology enables cost-effective photonic integrated circuits for applications such as microwave photonics and data communications. Optical frequency synthesis with ∼1.5 Hz accuracy is demonstrated using heterogeneous integration. Silicon photonics applications that will benefit from future heterogeneous integration are also demonstrated, including high dynamic range microwave photonic links and optical switching technology that scales to hyperscale datacenters with hundreds of thousands of servers.
Clamped state solution of artificial neural network for real-time economic dispatch (1995)

This paper presents a novel method for the real-time economic dispatch using clamped state variable formulation of the Kennedy, Chua and Lin (1988) artificial neural network (ANN). An efficient economic power dispatch algorithm must use real-time load conditions and the loss penalty-factor for representation of transmission losses in power system. The approach described in this paper assumes that an interface program will calculate the penalty factors for the current power flow state, as calculated by a state estimation program. The proposed method employs an ANN to enhance the speed and capability of algorithms which may use heuristics for online use. The ability of processing feedbacks in a collective parallel analog mode enables a neural network to simulate the dynamics that represent the optimization of an objective function subjected to its constraints for a given optimization model. Different techniques may be used to simulate the neural dynamic system. In this study, the authors propose a new method of simulation called the clamped state variable (CSV) technique. The new approach is very simple and it takes smaller computer time for the algorithm to converge than the complete circuit simulation. The results obtained by the CSV method are very close to that of numerical methods and are reported in this paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H(3)R) in the regulation of food intake and body weight and the potential therapeutic effect of H(3)R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H(3)R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-alpha-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochemical, pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin-1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]methanone 36 are detailed.
Pyranosyl‐RNA: Paarung zwischen homochiralen Oligonucleotidsträngen entgegengesetzten Chiralitätssinns (1996)

Die zu natürlicher RNA isomere Pyranosyl‐RNA (p‐RNA) – Ausschnitt schematisch im Bild rechts – zeigt höchst bemerkenswerte Eigenschaften. Homochirale Stränge mit entgegengesetztem Chiralitätssinn bilden quasiracemische Duplexe nach Basenauswahlregeln, die von jenen der isochiralen Paarung verschieden sind. magnified image
MPC-Based Fast Frequency Control of Voltage Source Converters in\n Low-Inertia Power Systems (2020)

A rapid deployment of renewable generation has led to significant reduction\nin the rotational system inertia and damping, thus making frequency control in\npower systems more challenging. This paper proposes a novel control scheme\nbased on Model Predictive Control (MPC) for converter-interfaced generators\noperating in a grid-forming mode, with the goal of exploiting their fast\nresponse capabilities to provide fast frequency control service to the system.\nThe controller manipulates converter power injections to limit the frequency\nnadir and rate-of-change-of-frequency after a disturbance. Both centralized and\ndecentralized MPC approaches are considered and compared in terms of\nperformance and practical implementation. Special attention is given to the\ndecentralized controller by generating an explicit MPC solution to enhance\ncomputational efficiency and reduce hardware requirements. Simulation results\nobtained from a high-fidelity differential-algebraic equation model of the IEEE\n39-bus system demonstrate the effectiveness of the proposed control schemes.\n
Eventrons (2006)

While real-time garbage collection has achieved worst-case latencies on the order of a millisecond, this technology is approaching its practical limits. For tasks requiring extremely low latency, and especially periodic tasks with frequencies above 1 KHz, Java programmers must currently resort to the NoHeapRealtimeThread construct of the Real-Time Specification for Java. This technique requires expensive run-time checks, can result in unpredictable low-level exceptions, and inhibits communication with the rest of the garbage-collected application. We present Eventrons , a programming construct that can arbitrarily preempt the garbage collector, yet guarantees safety and allows its data to be visible to the garbage-collected heap. Eventrons are a strict subset of Java, and require no run-time memory access checks. Safety is enforced using a data-sensitive analysis and simple run-time support with extremely low overhead. We have implemented Eventrons in IBM's J9 Java virtual machine, and present experimental results in which we ran Eventrons at frequencies up to 22 KHz (a 45 μ s period). Across 10 million periods, 99.997% of the executions ran within 10 μ ss of their deadline, compared to 99.999% of the executions of the equivalent program written in C.
Topological Descriptor for Oxygens in Zeolites. Analysis of Ring Counting in Tetracoordinated Nets (2009)

Topology of zeolite nets has been studied in terms of rings. A freely available software tool for the calculation and systematic analysis of the rings in zeolite nets is presented. Ring indices, associated to T (tetrahedral) and O atoms, are defined as a new topological concept. Ring count is also proposed as a topological descriptor of a structure which gives a fingerprint of the rings (number and size) in a zeotype. These topological concepts are linked with chemical descriptors and used together to systematize and characterize useful information on zeolites such as ring occurrence and TOT angles between different structures. Ring indices of O-sites can be employed to characterize the location of protons in acid zeolites giving a structured information on the ring environment of each active site.
A new approach for advanced plasticity and fracture modelling (2019)

Abstract A solution to the challenge of modelling the general yielding behaviour including fracture initiation is proposed based on non-associated flow rule. A decoupled formulation with employment of a Lagrangian interpolation function is established to develop a general fracture criterion that considers the mutual effect of the material anisotropy, the strain rate, and the temperature on the onset of fracture. An advanced constitutive law is also developed to accurately describe the evolution of the anisotropy/asymmetry-induced distortional yielding behaviour, using neither any interpolation nor optimization techniques for the calibration of the yield surface. The proposed models are successfully applied to various types of metallic materials to validate their noticeable flexibility and applicability in describing the general material behaviour during various forming processes.
A Direct Conversion Receiver with Fast-Settling DC Offset Canceller (2007)

In direct conversion receivers, which down-convert RF signal to baseband directly, DC offset in the baseband signal significantly degrades receiver performance and thus the DC offset cancellation is one of the most important issues regarding the achievement of high receiving performance. This paper proposes a fast-settling DC offset canceller that eliminates DC offset using stored DC data estimated in advance so as to cancel residual DC offset by a feedback loop. Experimental results and computer simulation results show that the DC offset canceller can eliminate a DC offset within 5 [musec], although it does not remove the desired signal component so as not to degrade BER (bit error rate) performance, because cut-off frequency in the HPF (high-pass filter) characteristic due to DC offset cancellation can remain low.
Benzimidazole Derivatives as Novel Nonpeptide Luteinizing Hormone‐Releasing Hormone (LHRH) Antagonists. Part 2. Benzimidazole‐5‐sulfonamides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.