gebhart/patrepeval huggingface dataset:
Development of a Coflowing Device for the Size-Controlled Preparation of Magnetic-Polymeric Microspheres as Embolization Agents in Magnetic Resonance Navigation Technology (2018)

Droplet microfluidics technology has recently been introduced to generate particles for many biomedical applications that include therapeutic embolizing agents in hepatic, uterine or bronchial arteries. Embolic agents are available in a variety of shapes and sizes that are adjusted according to the target vessel characteristics. Magnetic embolic agents can additionally be navigated to the target location (e.g., a tumor) through the blood system by applying an external magnetic field. This technology is termed Magnetic Resonance Navigation (MRN). Here we introduce a high throughput method to produce homogeneously sized magnetic microspheres (MMS) as blood vessel embolic agents for use in combination with MRN. The system for MMS production consists of a simple 3D printed micro coflowing device that is able to produce biocompatible, degradation rate controllable poly(lactic-<i>co</i>-glycolic acid) (PLGA) microspheres encasing magnetic nanoparticles. Axisymmetric flow is obtained with a central needle injecting the dispersed phase surrounded by a continuous phase and leads to the formation of size-controlled droplets that turn into homogeneously sized MMS linearly dependent on the inner needle diameter. MMS morphology, mean particle size and size distribution were quantified from SEM images. Magnetic performance of MMS was investigated using a vibrating sample magnetometer. MMS were nontoxic toward HUVEC (human umbilical vein endothelial cells) and HEK293 (human embryonic kidney) cells. The presented micro coflowing method allows for the reliable production of large MMS sized 130-700 μm with narrow size distribution (CV < 7%) and magnetic properties useful for MRN.
Abstract 5629: Prolyl isomerase Pin1 negatively regulates CDK10 stability to induce tamoxifen resistance in breast cancer. (2013)

Abstract Endocrine therapies that inhibit estrogen receptor (ER)-α signaling are the most common and effective treatment for ER-α-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The aim of this study was to elucidate the mechanisms by which downregulation of CDK10 expression confers resistance to tamoxifen in breast cancer. Here, we show that peptidyl-prolyl isomerase Pin1 downregulates CDK10 protein as a result of its interaction with and ubiquitination of CDK10, thereby affecting CDK10-dependent Raf-1 phosphorylation (S338). Pin1-/- mouse embryonic fibroblasts (MEFs) show higher CDK10 expression than Pin1+/+ MEFs, whereas CDK10 protein was downregulated in the rescued Pin1-/- MEFs after reexpression of Pin1. Pin1 silencing in SKBR-3 and MCF7 cells increased the CDK10 expression. In human tamoxifen-resistant breast cancer and tamoxifen-resistant MCF7 cells, immunohistochemical staining and immunoblotting analysis shows an inverse correlation between the expression of CDK10 and the degree of tamoxifen resistance. There was also a positive correlation between the high level of P-Raf-1 (Ser338) and Pin1 in human tamoxifen-resistant breast cancer and tamoxifen-resistant MCF7 (TAMR-MCF7) cells. Importantly, 4-OH tamoxifen (4-OHT), when used in combination with overexpressed CDK10 or Raf-1 inhibitor, increased cleaved PARP and DNA fragmentation to inhibit cologenic growth of MCF7 cells and tamoxifen-resistant MCF7 cells, respectively. On the basis of these findings, we suggest that the Pin1-mediated CDK10 ubiquitination is a major regulator of tamoxifen-resistant breast cancer cell growth and survival. Citation Format: Prem Kharam, Hong Seok Choi. Prolyl isomerase Pin1 negatively regulates CDK10 stability to induce tamoxifen resistance in breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5629. doi:10.1158/1538-7445.AM2013-5629 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Application of the Isoparametric Finite-Element Method to Integral Equations (1977)

A refined numerical technique, based on a variational approach using isoparametric finite-elements is presented for the solution of three-dimensional electromagnetic scattering problems. This technique allows a higher-order approximation of the unknown function over a bounding surface described by non-planar elements. The Rayleigh-Ritz procedure is used to discretize the integral equation. Kernel singularities are treated by separating them from the main integral and solving them analytically. A procedure for establishing the system matrix in a block-sparse form will be described [5].
Organic Electronics: Doping‐Free Organic Light‐Emitting Diodes with Very High Power Efficiency, Simple Device Structure, and Superior Spectral Performance (Adv. Funct. Mater. 30/2014) (2014)

A square-planar Pt(II)-pyridyltriazolate phosphor with excellent n-type electrical behavior is used for dopant-free white organic light-emitting diodes (DFW-OLEDs) by B. E. Gnade, M. A. Omary, and co-workers. On page 4746, the devices display a simple dopant-free architecture and exhibit unparalleled color stability, with negligible efficiency rolloff at high luminance levels so as to make them competitive with today's state-of-the-art doped devices.
Novel Highly Substituted Biraryl Ethers, Phomosines D–G, Isolated from the Endophytic Fungus Phomopsis sp. from Adenocarpus foliolosus (2005)

Abstract Six new metabolites, phomosines D–G ( 4 – 7 ), 6‐hydroxy‐6‐isopropylcyclohex‐1‐enecarboxylic acid ( 8 ) and(1a S ,3 R ,4 R ,4a R ,6 S ,7 R ,8a S )‐7‐chloro‐3,6‐dihydroxy‐3,4a,8,8‐tetramethyl‐octahydro‐1a H ‐naphtho[1‐ b ]oxirene‐4‐carboxylic acid ( 9 ) were isolated together with seven known compounds ( 1 – 3 , 10 – 13 ) from the endophytic fungus Phomopsis sp. The structures of 1 – 13 were determined by spectroscopic methods (mainly extensive 1D and 2D NMR experiments and by mass spectrometric measurements). The antibacterial, fungicidal, and herbicidal properties of the new compounds were evaluated. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Emulation of the structure of the Saposin protein fold by a lung surfactant peptide construct of surfactant Protein B (2022)

The three-dimensional structure of the synthetic lung Surfactant Protein B Peptide Super Mini-B was determined using an integrative experimental approach, including mass spectrometry and isotope enhanced Fourier-transform infrared (FTIR) spectroscopy. Mass spectral analysis of the peptide, oxidized by solvent assisted region-specific disulfide formation, confirmed that the correct folding and disulfide pairing could be facilitated using two different oxidative structure-promoting solvent systems. Residue specific analysis by isotope enhanced FTIR indicated that the N-terminal and C-terminal domains have well defined α-helical amino acid sequences. Using these experimentally derived measures of distance constraints and disulfide connectivity, the ensemble was further refined with molecular dynamics to provide a medium resolution, residue-specific structure for the peptide construct in a simulated synthetic lung surfactant lipid multilayer environment. The disulfide connectivity combined with the α-helical elements stabilize the peptide conformationally to form a helical hairpin structure that resembles critical elements of the Saposin protein fold of the predicted full-length Surfactant Protein B structure.
Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism (1982)

A Mg-ATP-dependent protein phosphatase has been reconstituted from the catalytic subunit of protein phosphatase-1 and inhibitor-2, and consists of a 1:1 complex between these proteins. Activation of this enzyme by glycogen synthase kinase-3 and Mg-ATP results from the phosphorylation of inhibitor-2 on a threonine residue(s) and is accompanied by the dissociation of the complex. The results prove that protein phosphatase-1 and the Mg-ATP-dependent protein phosphatase contain the same catalytic subunit, and that they are interconvertible forms of the same enzyme.
Microparticules « intelligentes » de silicium poreux pour la détection d’agents chimiques et biologiques (2006)

Aujourd’hui, les secteurs de l’environnement, de la médecine, de la surveillance ont nécessité de disposer de capteurs intelligents, autonomes, miniaturisés et peu énergivores. Cet article présente la préparation de particules de silicium poreux «&nbsp;encodés&nbsp;» optiquement à l’échelle micrométrique. Ces particules possèdent les propriétés de s’assembler, de s’orienter, de réagir à leur environnement et de communiquer, indifféremment dans l’atmosphère ou dans l’eau. Des limitations restent cependant encore à dépasser, celles de leur spécificité par exemple.
Cover Feature: Synthesis of Cyclen‐Functionalized Ethenylene‐Based Periodic Mesoporous Organosilica Nanoparticles and Metal‐Ion Adsorption Studies (ChemNanoMat 11/2020) (2020)

Why would heavy metal ever go away? Cyclen-functionalized ethenylene-based periodic mesoporous organosilica nanoparticles were prepared for heavy metal removal from model solutions. The kinetics and isotherms of adsorption of nickel and cobalt were determined, and these nanomaterials showed high uptake of metals (up to 3.9 mmol g−1). They demonstrated pronounced selectivity in the separation of rare earth elements (e.g., neodymium and samarium) from late transition metals, e.g. Ni(II) and Co(II), by adsorption and even more so by controlled desorption. More information can be found in the Full Paper by Jean-Olivier Durand, Roser Pleixats, Gulaim Seisenbaeva et al.
Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis (2009)

Despite the growing interest in the Fhit tumor suppressor protein, frequently deleted in human cancers, the mechanism of its powerful proapoptotic activity has remained elusive. We here demonstrate that Fhit sensitizes the low-affinity Ca(2+) transporters of mitochondria, enhancing Ca(2+) uptake into the organelle both in intact and in permabilized cells, and potentiating the effect of apoptotic agents. This effect can be attributed to the fraction of Fhit sorted to mitochondria, as a fully mitochondrial Fhit (a chimeric protein including a mitochondrial targeting sequence) retains the Ca(2+) signaling properties of Fhit and the proapoptotic activity of the native protein (whereas the effects on the cell cycle are lost). Thus, the partial sorting of Fhit to mitochondria allows to finely tune the sensitivity of the organelle to the highly pleiomorphic Ca(2+) signals, synergizing with apoptotic challenges. This concept, and the identification of the molecular machinery, may provide ways to act on apoptotic cell death and its derangement in cancer.
Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals (2005)

Improvement of scintigraphic tumor imaging is extensively determined by the development of more tumor specific radiopharmaceuticals. Thus, to improve the differential diagnosis, prognosis, planning and monitoring of cancer treatment, several functional pharmaceuticals have been developed. Application of molecular targets for cancer imaging, therapy and prevention using generator-produced isotopes are the major focus of ongoing research projects. Radionuclide imaging modalities (positron emission tomography, PET; single photon emission computed tomography, SPECT) are diagnostic cross-sectional imaging techniques that map the location and concentration of radionuclide-labeled radiotracers. 99mTc- and 68Ga-labeled agents using ethylenedicysteine (EC) as a chelator were synthesized and their potential uses to assess tumor targets were evaluated. 99mTc (t1/2=6 hr, 140 keV) is used for SPECT and 68Ga (t1/2=68 min, 511 keV) is for PET. Molecular targets labeled with Tc-99m and Ga-68 can be utilized for prediction of therapeutic response, monitoring tumor response to treatment and differential diagnosis. Molecular targets for oncological research in (1) cell apoptosis, (2) gene and nucleic acid-based approach, (3) angiogenesis (4) tumor hypoxia, and (5) metabolic imaging are discussed. Numerous imaging ligands in these categories have been developed and evaluated in animals and humans. Molecular targets were imaged and their potential to redirect optimal cancer diagnosis and therapeutics were demonstrated.
Lifting for nonlinear wavelet image processing (1999)

This paper develops new algorithms for adapted multiscale analysis and signal adaptive wavelet transforms. We construct our adaptive transforms with the lifting scheme, which decomposes the wavelet transform into prediction and update stages. We adapt the prediction stage to the signal structure and design the update stage to preserve the desirable properties of the wavelet transform. The resulting scale and spatially adaptive transforms are extended to the image estimation problem; our new image transforms show improved denoising performance over existing (non-adaptive) orthogonal transforms.
Copeptin Response to Clinical Maximal Exercise Tests (2010)

and the "Duplicate/Update" label has been renamed "Update," as some users expressed concern over the word "Duplicate." With these changes in mind, we would like to emphasize that the ultimate purpose of the De ja `Vu database is to maintain the integrity of biomedical literature, a goal that can be achieved only by a thorough and accurate interpretation of the information contained within. We therefore extend to both the editors and reviewers of Clinical Chemistry an invitation to explore the De ja `Vu database and its accompanying text similarity tool, eTBLAST (http://etblast.org), to help identify future submissions of questionable manuscripts before they are published.
Jonathan Nicholas Wilson (2007)

After gaining first class honours in an intercalated BMedSci in 1991, Jonathan Nicholas Wilson (“Jonny”) completed his undergraduate medical training and continued postgraduate studies in paediatrics at Nottingham, Kettering, and Oxford, where he …
Spectral and Energy Efficiency for Large-Scale Multiple-Input-Multiple-Output Two-Way Hybrid Relaying With Multi-Pair Users Under Imperfect Channel State Information (2021)

Herein, we investigate the system spectral efficiency (SSE) and system energy efficiency (SEE) for massive two-way multiple-input-multiple-output (MIMO) relaying networks while considering imperfect channel state information (CSI) with K-pair users in the presence of the hybrid relaying processing. First, we obtain the general expression of the signal-to-interference-and-noise-ratio (SINR) for the considered system when the antenna number of the relay station (RS) M tends to be significantly large. Next, we consider the power scaling scheme (PSS) and achieve asymptotic SSE and SEE. We set the pilot sequence transmit power PP to be fixed PP and variable PP. For a nonvanishing SINR, we achieve different power scaling cases under fixed and variable PP. For a fixed PP value, the optimal PSS of the SSE can be obtained when the transmit power of each user can be scaled byM, whereas that of the SEE can be achieved when the transmit power of both the RS and each user terminal can be reduced byM. Based on the variable value of PP, the optimal PSS’ of both the SSE and the SEE can be used when the transmit power of both RS and each user can be scaled by M1/3. Thus, we conclude that the required SSE and SEE performances can be attained in multi-pair massive MIMO two-way relaying networks with a considerably low transmit power at RS and/or the transmit power of each user. The analytical results for the same are validated via simulation.
Synthesis and Characterization of Main-Chain High-Temperature Nonlinear Optical-Active Polymers. Poly(aryl ether-oxazoles) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of Main-Chain High-Temperature Nonlinear Optical-Active Polymers. Poly(aryl ether-oxazoles)Kenneth R. Carter, James L. Hedrick, Robert J. Twieg, Tracy J. Matray, and Cecilia A. WalshCite this: Macromolecules 1994, 27, 17, 4851–4852Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ma00095a033https://doi.org/10.1021/ma00095a033research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Directional characteristics of THz outdoor channels - measurement and system performance implications (2021)

Next-generation wireless communication systems need to provide extremely high data rates that can enable upcoming applications. To obtain the large contiguous bandwidth required for providing such high data rates, usage of the spectrum above 100 GHz is envisioned. In order to determine the maximum data rate available in these bands, it is necessary to analyze the channels’ capacity. While previous capacity analyses for outdoor THz channels were based on models with simplifying assumptions, in the current paper we present the first capacity analysis using real-world measurement data for frequencies between 145 and 146 GHz collected from our recent double-directional urban channel measurements. The impact of various beamforming methods, including pure analog beamswitching and pure digital beamforming, on the achievable rates in both piconets and device-to-device settings are also investigated. These analyses are important to move towards the eventual realization of THz band communication.
AUTOMATIC CAR DRIVING DETECTION USING RAW ACCELEROMETRY DATA (2017)

Measuring physical activity using wearable devices has gained popularity in older populations. Raw data collected from them is summarized as “activity counts”, which combine information of human activity with environmental vibrations. Driving is a major sedentary activity that can artificially increase these counts. Thus, it is important to identify periods of driving and quantify the bias induced by driving in activity counts. To address these problems, we propose a Detection Algorithm of Driving via Accelerometry (DADA), which is based on short-time Fourier transform applied to the raw accelerometry data identifying the frequencies’ ranges specific to car driving. We test DADA’s performance on data collected using wrist-worn ActiGraph devices in an experiment conducted on 24 subjects. The median AUC for predicting driving periods was 0.94. The activity count bias induced by driving per unit of time was on average equal to 16% of the average activity counts generated during walking.
Benefits and drawbacks of thermal pre-hydrolysis for operational performance of wastewater treatment plants (2008)

This paper presents benefits and potential drawbacks of thermal pre-hydrolysis of sewage sludge from an operator's prospective. The innovative continuous Thermo-Pressure-Hydrolysis Process (TDH) has been tested in full-scale at Zirl wastewater treatment plant (WWTP), Austria, and its influence on sludge digestion and dewatering has been evaluated. A mathematical plant-wide model with application of the IWA Activated Sludge Model No.1 (ASM1) and the Anaerobic Digestion Model No.1 (ADM1) has been used for a systematic comparison of both scenarios--operational plant performance with and without thermal pre-hydrolysis. The impacts of TDH pre-hydrolysis on biogas potential, dewatering performance and return load in terms of ammonia and inert organic compounds (Si) have been simulated by the calibrated model and are displayed by Sankey mass flow figures. Implementation of full scale TDH process provided higher anaerobic degradation efficiency with subsequent increased biogas production (+75-80%) from waste activated sludge (WAS). Both effects--enhanced degradation of organic matter and improved cake's solids content from 25.2 to 32.7% TSS--promise a reduction in sludge disposal costs of about 25%. However, increased ammonia release and generation of soluble inerts Si was observed when TDH process was introduced.
Capillaritis (purpura simplex) associated with use of aminoglutethimide in Cushing’s syndrome (1994)

Journal Article Capillaritis (purpura simplex) associated with use of aminoglutethimide in Cushing’s syndrome Get access Constantine A. Stratakis, M.D., D.Sc., Constantine A. Stratakis, M.D., D.Sc. Fellow Pediatric Endocrinology. Genetics, and Metabolism. National Institutes of Health/ Georgetown University Fellowship Program. Bethesda. MD Search for other works by this author on: Oxford Academic Google Scholar George P. Chrousos, M.D., FAAP, FACP George P. Chrousos, M.D., FAAP, FACP Senior Investigator and Chief Section on Pediatric Endocrinology. Developmental Endocrinology Branch, and Director. Pediatric Endocrinology Training Program, National Institute of Child Health and Human Development. Bethesda. He is also Professor of Pediatrics. Physiology, and Biophysics. Georgetown University. Washington. DC. Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 51, Issue 20, 15 October 1994, Pages 2589–2591, https://doi.org/10.1093/ajhp/51.20.2589 Published: 15 October 1994
Determination of Phenolic Compounds of Dry Beans Using Vanillin, Redox and Precipitation Assays (1987)

ABSTRACT Phenolic compounds of ten genotypes of dry beans ( Phaseolus vulgaris L.) were investigated using four different methods. Assayable tannins using the 0.5% vanillin assay ranged from 49–306 mg catechin equivalents/100 g beans. Significant differences were observed for tannins measured by the vanillin and the protein precipitable phenol tests. Of the two redox assays, the Prussian blue assay gave significantly higher total phenol values than the Folin‐Ciocalteu assay. Both these reagents were more sensitive to tannic acid than to catechin. Although tannin values varied 2–3 fold for a given variety, excellent correlation was observed between the different assays employed for bean tannin analysis.
Sensorless flow rate estimation in frequency-converter-driven fans (2011)

Fan systems account for approximately 11 % of the industrial electricity consumption. Previous studies indicate that there is a significant energy savings potential in fan systems. Increase in the price of electricity has brought forth a need for easily implementable methods to measure the efficiency of fan systems. In this paper, a sensorless fan operating point estimation method is introduced and the limitations of the method are discussed. Operation of the sensorless estimation method is validated through laboratory measurements. It is found that the estimation method is accurate enough to be used for energy efficiency analyses and the detection of inefficient fan operation.