gebhart/patrepeval huggingface dataset:
XML Schema Integration and E-Commerce (2008)

XML (eXtensible Markup Language) is used to describe semi-structured data, i.e., irregular or incomplete data whose structure may be subject to unpredictable changes. Unlike traditional semi-structured data, XML documents are self-describing, thus XML provides a platform-independent means to describe data and, therefore, can transport data from one platform to another (Bray, Paoli, &amp; Sperberg-McQueen, 1998). XML documents can be both created and used by applications. The valid content, allowed structure, and metadata properties of XML documents are described by their related schema(s) (Thompson, Beech, Maloney, &amp; Mendelsohn, 2001). An XML document is said to be valid if it conforms to its related schema. A schema also gives additional semantic meaning to the data it is used to tag. The schema is provided independently of the data it describes. Any given data set may rely on multiple schemas for validation. Any given schema may itself refer to multiple schemas.
Optimization of a simplified automobile finite element model using time varying injury metrics. (2014)

In 2011, frontal crashes resulted in 55% of passenger car injuries with 10,277 fatalities and 866,000 injuries in the United States. To better understand frontal crash injury mechanisms, human body finite element models (FEMs) can be used to reconstruct Crash Injury Research and Engineering Network (CIREN) cases. A limitation of this method is the paucity of vehicle FEMs; therefore, we developed a functionally equivalent simplified vehicle model. The New Car Assessment Program (NCAP) data for our selected vehicle was from a frontal collision with Hybrid III (H3) Anthropomorphic Test Device (ATD) occupant. From NCAP test reports, the vehicle geometry was created and the H3 ATD was positioned. The material and component properties optimized using a variation study process were: steering column shear bolt fracture force and stroke resistance, seatbelt pretensioner force, frontal and knee bolster airbag stiffness, and belt friction through the D-ring. These parameters were varied using three successive Latin Hypercube Designs of Experiments with 130-200 simulations each. The H3 injury response was compared to the reported NCAP frontal test results for the head, chest and pelvis accelerations, and seat belt and femur forces. The phase, magnitude, and comprehensive error factors, from a Sprague and Geers analysis were calculated for each injury metric and then combined to determine the simulations with the best match to the crash test. The Sprague and Geers analyses typically yield error factors ranging from 0 to 1 with lower scores being more optimized. The total body injury response error factor for the most optimized simulation from each round of the variation study decreased from 0.466 to 0.395 to 0.360. This procedure to optimize vehicle FEMs is a valuable tool to conduct future CIREN case reconstructions in a variety of vehicles.
Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists (1998)

gamma-Melanocyte-stimulating hormone (gamma-MSH), atrial natriuretic peptide (ANP), and oxytocin have been identified as candidate hormonal mediators of the reflex natriuresis that follows acute unilateral nephrectomy (AUN). Pharmacological characterization of the third melanocortin receptor (MC3-R) indicates that it uniquely responds to physiological concentrations of gamma-MSH. We tested the roles of gamma-MSH, ANP, and oxytocin in the postnephrectomy natriuresis by carrying out AUN during continuous intrarenal infusion of specific antagonists for their cognate receptors. In anesthetized Sprague-Dawley rats, urinary sodium excretion (UNaV) increased from 0.34 +/- 0.04 to 1.12 +/- 0.11 mu eq/min 90 min after AUN (P < 0.001). No change in UNaV occurred in rats undergoing a sham AUN procedure. Plasma immunoreactive gamma-MSH concentration was 53 +/- 8 fmol/ml after sham AUN but 112 +/- 17 fmol/ml after AUN (P < 0.01). SHU-9119 and SHU-9005 are substituted derivatives of alpha-MSH with potent antagonism at the MC3-R in vitro. Infusion of these compounds at 5 pmol/min completely blocked the natriuretic response to AUN despite a similar elevation in plasma gamma-MSH (111 +/- 12 vs. 49 +/- 8 fmol/ml in sham rats, P < 0.01). Intrarenal infusion of the ANP receptor antagonist A-71915 (5 pmol/min) or the oxytocin receptor antagonist [d(CH2)(5)1, Tyr(Me)2,Orn8] vasotocin (10 pmol/min) effectively inhibited the natriuresis induced by intravenous infusion of ANP or oxytocin (each at 1 pmol/min), respectively, but did not block the natriuresis after AUN. Plasma immunoreactivity of these peptides was not increased after AUN. These results indicate that reflex natriuresis after AUN is accompanied by an increase in plasma gamma-MSH but not ANP or oxytocin concentration and is prevented by intrarenal infusion of receptor antagonists with selectivity for MC3-R. The data indicate that gamma-MSH or a closely related peptide mediates postnephrectomy natriuresis and provide further support for the possibility that gamma-MSH may play a wider role in sodium homeostasis.
Turbulent Flow Friction Factor Calculation Using a Mathematically Exact Alternative to the Colebrook–White Equation (2006)

We present a novel, mathematically equivalent representation of the Colebrook–White equation to compute friction factor for turbulent flow in rough pipes. This new form is simple, no iterative calculations are necessary, and is well suited for accurate friction factor estimation. A limiting case of this equation provided friction factor estimates with a maximum absolute error of 0.029 and a maximum percentage error of 1% over a 20×500 grid of ε∕D and R values (10−6⩽ε∕D⩽5×10−2; 4×103<R<108). This was more accurate than the best currently available noniterative approximation of the Colebrook–White equation (maximum absolute error of 0.058; maximum percentage error of 1.42%). The superior accuracy, however, was obtained at the expense of a 30% increase in computational effort over the noniterative approximation. The novel equation presented in this study is theoretical and eliminates the need for best fit parameters or complicated initial guesses that are a characteristic of various empirical approximations proposed to date. The simplicity with which this new equation can be solved, coupled with its smooth and predictable error behavior, should make it the method of choice for estimating turbulent flow friction factor in rough pipes.
Influence of pressure on the retention of sugars in hydrophilic interaction chromatography (2009)

Pressure can influence the retention of analytes in hydrophilic interaction chromatography as well as in RP chromatography. We demonstrate that the retention of sugars in hydrophilic interaction chromatography decreases with pressure, and interpret the observation as a gain in solvation, or more specifically hydration, as the sugar molecules enter the water-rich stationary phase.
Supplementary Table 2 from Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility (2023)

Supplementary Table 2 from Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility
Arthroscopy Up to Date: Hip Femoroacetabular Impingement (2015)

Level IV, systematic review of Level IV studies.
Generation of nitrogen-vacancy ensembles in diamond for quantum sensors: Optimization and scalability of CVD processes (2020)

Ensembles of nitrogen-vacancy (NV) centers in diamond are a leading platform for practical quantum sensors. Reproducible and scalable fabrication of NV-ensembles with desired properties is crucial. This work addresses these challenges by developing a chemical vapor deposition (CVD) synthesis process to produce diamond material at scale with improved NV-ensemble properties for a target NV density. The material reported in this work enables immediate sensitivity improvements for current devices. In addition, techniques established in this work for material and sensor characterization at different stages of the CVD synthesis process provide metrics for future efforts targeting other NV densities or sample geometries.
Performance analysis of blind carrier phase estimators for general QAM constellations (2001)

Large quadrature amplitude modulation (QAM) constellations are currently used in throughput efficient high-speed communication applications such as digital TV. For such large signal constellations, carrier-phase synchronization is a crucial problem because for efficiency reasons, the carrier acquisition must often be performed blindly, without the use of training or pilot sequences. The goal of the paper is to provide thorough performance analysis of the blind carrier phase estimators that have been proposed in the literature and to assess their relative merits.
ChemInform Abstract: Photoinduced Single Electron Transfer on 5‐Aryl‐1,2,4‐oxadiazoles: Some Mechanistic Investigations in the Synthesis of Quinazolin‐4‐ones. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Leapfrog collaboration: Toward determinism and predictability in industrial-IoT applications (2017)

Recent standardization activities bring high Quality of Service (QoS) and predictability to Internet of Things (IoT), which are “going industrial”. Critical applications such as industrial process control, smart grid or vehicle automation require deterministic transmissions with properties such as on-time data deliveries and end-to-end reliability close to 100%. Traditional radio technologies based on collision detection and retransmission introduce unpredictable delays, and can not ensure reliable delivery within a narrowly bounded time. This paper proposes to exploit spatial diversity and packet redundancy to compensate for the inherently lossy wireless medium. We introduce “Leapfrog Collaboration”, a communication mechanism which takes advantage of communication overhearing, and in which parallel transmissions over two paths are scheduled. Promiscuous listening between the paths enables nodes to possibly overhear transmissions on the other. We evaluate the delay and jitter of the communication by simulation using Contiki OS and show that Leapfrog Collaboration outperforms the default retransmission-based approach of IEEE802.15.4-TSCH by up to 28% and 54%, respectively, while providing high network reliability.
Fatigue Damage Analysis of an Elastomeric Tank Track Component (2012)

The backerpad on the Abrams tank track system is an elastomeric cushion that protects the track and has direct contact with the tank's wheels. The backerpad's service life is limited by harsh operating conditions, and system designers are challenged to extend that limit. Accordingly, an analysis is demonstrated here of an experimental backerpad's fatigue performance under the action of a tank roadwheel repeatedly rolling over the pad. First, the elastomer is characterized via tests that define its fatigue behavior. Next, the multiaxial, variable amplitude duty cycle of the pad through a representative rollover event is computed in ABAQUS/Explicit. Finally, the material characterization and duty cycle are analyzed via the fe-safe/Rubber fatigue life solver to estimate damage accumulation in each finite element of the model. The calculation identifies the location and number of duty cycle repeats associated with the first appearance of 1 mm cracks for the selected duty cycle, providing an example of how fatigue analysis may be applied to understand damage development in elastomeric components.
UGS video target detection and discrimination (2007)

This project focuses on developing electro-optic algorithms which rank images by their likelihood of containing vehicles and people. These algorithms have been applied to images obtained from Textron's Terrain Commander 2 (TC2) Unattended Ground Sensor system. The TC2 is a multi-sensor surveillance system used in military applications. It combines infrared, acoustic, seismic, magnetic, and electro-optic sensors to detect nearby targets. When targets are detected by the seismic and acoustic sensors, the system is triggered and images are taken in the visible and infrared spectrum. The original Terrain Commander system occasionally captured and transmitted an excessive number of images, sometimes triggered by undesirable targets such as swaying trees. This wasted communications bandwidth, increased power consumption, and resulted in a large amount of end-user time being spent evaluating unimportant images. The algorithms discussed here help alleviate these problems. These algorithms are currently optimized for infra-red images, which give the best visibility in a wide range of environments, but could be adapted to visible imagery as well. It is important that the algorithms be robust, with minimal dependency on user input. They should be effective when tracking varying numbers of targets of different sizes and orientations, despite the low resolutions of the images used. Most importantly, the algorithms must be appropriate for implementation on a low-power processor in real time. This would enable us to maintain frame rates of 2 Hz for effective surveillance operations. Throughout our project we have implemented several algorithms, and used an appropriate methodology to quantitatively compare their performance. They are discussed in this paper.
Fabrication of Short-Range Ordered Nanoholes on Silicon Surfaces by Electron Irradiation (2007)

Silicon surface nanoholes, which are small pits introduced spontaneously on the electron exit surfaces of silicon foils by electron irradiation, distribute orderly in a short range. The nearest-neighbor distance and mean opening area of the nanoholes exhibit an Arrhenius-like behavior at high temperatures. The formation mechanism is discussed in terms of the migration of surface vacancies under electron irradiation conditions, and the activation energy of the migration is estimated to be 0.3±0.04 eV.
Demonstration of long-range surface plasmon-polariton waveguide sensors with asymmetric double-electrode structures (2010)

We demonstrate a long-range surface plasmon-polaritons (LRSPP) refractive-index sensor using an asymmetric double-electrode LRSPP waveguide configuration. The LRSPP sensor is inherently self-referencing by virtue of two Bragg wavelengths in the transmission spectrum generated by a Bragg grating. The measured sensitivity is about 130 nm/RIU and 27 pm/K, which means a sensing resolution of ∼10−6 RIU and a temperature determination with an inaccuracy of 0.04 K under measurement accuracy of the Bragg wavelength of 1 pm. The sensor dimensions of 1.95 mm in total length and submicrometer in fluidic-channel thickness may be desirable for highly integrated sensors based on LRSPP.
Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA (2012)

LANA is essential for tethering the Kaposi's sarcoma-associated herpesvirus (KSHV) genome to metaphase chromosomes and for modulating host-cell gene expression, but the binding sites in the host-chromosome remain unknown. Here, we use LANA-specific chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to identify LANA binding sites in the viral and host-cell genomes of a latently infected pleural effusion lymphoma cell line BCBL1. LANA bound with high occupancy to the KSHV genome terminal repeats (TR) and to a few minor binding sites in the KSHV genome, including the LANA promoter region. We identified 256 putative LANA binding site peaks with P < 0.01 and overlap in two independent ChIP-Seq experiments. We validated several of the high-occupancy binding sites by conventional ChIP assays and quantitative PCR. Candidate cellular LANA binding motifs were identified and assayed for binding to purified recombinant LANA protein in vitro but bound with low affinity compared to the viral TR binding site. More than half of the LANA binding sites (170/256) could be mapped to within 2.5 kb of a cellular gene transcript. Pathways and Gene Ontogeny (GO) analysis revealed that LANA binds to genes within the p53 and tumor necrosis factor (TNF) regulatory network. Further analysis revealed partial overlap of LANA and STAT1 binding sites in several gamma interferon (IFN-γ)-regulated genes. We show that ectopic expression of LANA can downmodulate IFN-γ-mediated activation of a subset of genes, including the TAP1 peptide transporter and proteasome subunit beta type 9 (PSMB9), both of which are required for class I antigen presentation. Our data provide a potential mechanism through which LANA may regulate several host cell pathways by direct binding to gene regulatory elements.
ChemInform Abstract: Preparation and Characterization of Ag2E (E: Se, Te) Using the Sonochemically Assisted Polyol Method. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Selective Room‐Temperature Hydrogenation of Carbonyl Compounds under Atmospheric Pressure over Platinum Nanoparticles Supported on Ceria‐Zirconia Mixed Oxide (2019)

A Pt/CeO 2 ‐ZrO 2 catalytic system was able to initiate an extremely intense hydrogen spillover providing a huge amount of activated hydrogen (12 mol/mol Pt) at temperatures –50°C ‐ +25°C, which was not observed before. The idea was to use this activated hydrogen for reduction of carbonyl compounds under ambient conditions. Thus, the efficient and selective heterogeneous hydrogenation of carbonyl compounds of different structure, including 5‐hydroxymethylfurfural and cinnamaldehyde, to the corresponding alcohols with quantitative yields was successfully performed over the Pt/CeO 2 ‐ZrO 2 catalysts at room‐temperature and atmospheric pressure of H 2 . The proposed catalysts afforded hydrogenation under significantly milder conditions with a much higher activity and selectivity compared to the commercial catalysts and reported catalytic systems. Hydrogenation of the C=O bond in the presence of a C=C bond proceeded with a high regioselectivity.
Evolution of neural symmetry and its coupled alignment to body plan morphology (2011)

Body morphology is thought to have heavily influenced the evolution of neural architecture. However, the extent of this interaction and its underlying principles are largely unclear. To help us elucidate these principles, we examine the artificial evolution of a hypothetical nervous system embedded in a fish-inspired animat. The aim is to observe the evolution of neural structures in relation to both body morphology and required motor primitives. Our investigations reveal that increasing the pressure to evolve a wider range of movements also results in higher levels of neural symmetry. We further examine how different body shapes affect the evolution of neural structure; we find that, in order to achieve optimal movements, the neural structure integrates and compensates for asymmetrical body morphology. Our study clearly indicates that different parts of the animat - specifically, nervous system and body plan - evolve in concert with and become highly functional with respect to the other parts. The autonomous emergence of morphological and neural computation in this model contributes to unveiling the surprisingly strong coupling of such systems in nature.
An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer (2021)

Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumor regression. Androgen deprivation therapy (ADT) still remains the first-line PCa therapy. Insufficiency of ADT over time leads to castration-resistant PCa (CRPC) in which the AR axis is still active, despite castrate levels of circulating androgens. Despite the approval and use of multiple generations of competitive AR antagonists (antiandrogens), antiandrogen resistance emerges rapidly in CRPC due to several mechanisms, mostly converging in the AR axis. Recent evidence from multiple groups have defined noncompetitive or noncanonical direct binding sites on AR that can be targeted to inhibit the AR axis. This review discusses new developments in the PCa treatment paradigm that includes the next-generation molecules to noncanonical sites, proteolysis targeting chimera (PROTAC), or noncanonical N-terminal domain (NTD)-binding of selective AR degraders (SARDs). A few lead compounds targeting each of these novel noncanonical sites or with SARD activity are discussed. Many of these ligands are still in preclinical development, and a few early clinical leads have emerged, but successful late-stage clinical data are still lacking. The breadth and diversity of targets provide hope that optimized noncanonical inhibitors and/or SARDs will be able to overcome antiandrogen-resistant CRPC.
Optimization of key building blocks for a large-area radiographic and fluoroscopic dynamic digital x-ray detector based on a-Si:H/CsI:Tl flat panel technology (2000)

This paper introduces the key design optimizations which have been carried out recently in Trixell in order to prepare the future family of large area, combined static (Radiography) and dynamic (Fluoroscopy, Cardio...) digital X-ray detectors based on a-Si:H/CsI:Tl flat panel technology. These optimizations have been carried out on a 16' X 12' prototype that has been designed and built in a product-oriented way. We describe the detector technology and give some of its main characteristics, as well as some preliminary measurement results.The heart of the new prototype is a Cesium Iodide scintillating screen, directly evaporated onto a 2 K X 2.5 K pixel, array of amorphous silicon photodiodes and TFTs deposited on a glass substrate. The pixel pitch is 155 micrometer. The detective flat panel is connected to dedicated electronics which provides line addressing, low-noise column readout and multiplexing into a serial electrical signal. This signal is digitized over 14 bits to provide a direct digital image output, available for the host radiology system via an optical fiber. This type of detector (flat panel + electronics) is built into a light and thin (less than 100 mm) packaging which can be easily integrated in various x-ray equipment such as R&F tables, Angiography systems (incl. Cardiology), and mobile C-arm systems.