gebhart/patrepeval huggingface dataset:
Activate capture and digital counting (AC + DC) assay for protein biomarker detection integrated with a self-powered microfluidic cartridge (2019)

We demonstrate a rapid, 2-step, and ultrasensitive assay approach for quantification of target protein molecules from a single droplet test sample. The assay is comprised of antibody-conjugated gold nanoparticles (AuNPs) that are "activated" when they are mixed with the test sample and bind their targets. The resulting liquid is passed through a microfluidic channel with a photonic crystal (PC) biosensor that is functionalized with secondary antibodies to the target biomarker, so that only activated AuNPs are captured. Utilizing recently demonstrated hybrid optical coupling between the plasmon resonance of the AuNP and the resonance of the PC, each captured AuNP efficiently quenches the resonant reflection of the PC, thus enabling the captured AuNPs to be digitally counted with high signal-to-noise. To achieve a 2-step assay process that is performed on a single droplet test sample without washing steps or active pump elements, controlled single-pass flow rate is obtained with an absorbing paper pad waste reservoir embedded in a microfluidic cartridge. We use the activate capture and digital counting (AC + DC) approach to demonstrate HIV-1 capsid antigen p24 detection from a 40 μL spiked-in human serum sample at a one thousand-fold dynamic range (1-10<sup>3</sup> pg mL<sup>-1</sup>) with only a 35-minute process that is compatible with point-of-care (POC) analysis. The AC + DC approach allows for ultrasensitive and ultrafast biomolecule detection, with potential applications in infectious disease diagnostics and early stage disease monitoring.
Dynamically Cross-Linked Polyolefins via Hydrogen Bonds: Tough yet Soft Thermoplastic Elastomers with High Elastic Recovery (2022)

The fabrication of polyolefin thermoplastic elastomers (P-TPEs) with superior robustness (high strength and high toughness) is challenging. Integrating dynamic (reversible) noncovalent cross-links into P-TPEs may solve the trade-off between strength and toughness and permanent (irreversible) cross-linking and elasticity. Here, we report a two-step synthesis of P-TPEs that contain flexible polymer chains and different thiol branches (less than 2.0 mol %) that cross-link the polymer chains through dynamic hydrogen bonding. The cross-linked polymers exhibit negligible hysteresis after being circularly stretched 10 times at low strain, that is, few dynamic H-bonds break per cycle and delocalize the stress concentration to withstand load and delay premature fracture. At large deformation, the polymers dissipate vast stress energy by the sacrificial H-bond scission: the H-bonds break and reform to prevent failure and to dictate simultaneously high fracture strength (σ up to 10.2 MPa) and high toughness (UT up to 22.6 MJ/m3). Meanwhile, the resultant materials present low stiffness (E ≈ 2.5 MPa), good extensibility (ε > 600%), and elastic recovery of 90% even at 680% strain. The cross-linked polyolefins are readily (re)processable, and tensile and elastic properties are largely recovered after being remolded at least twice.
Random energy charging for reviving sensors in wireless sensor network (2012)

In wireless sensor networks, the lifetime of the sensors restricts the performance of the sensor network. In order to overcome this restriction, the sensors can be revived by frequently recharging the battery in each node. Recent technologies have simplified the energy charging process using wireless energy transmission. However, the efficiency of energy transmission reduces rapidly over long distance, consequently making it difficult to transmit energy to multiple nodes in a wide area. Energy can be delivered to each node by a wireless charging vehicle (WCV) which has high mobility and large energy capacity. Even with such WCV, a node battery is frequently depleted which makes the node stop operating until the battery is recharged by the WCV. If the frequency of energy charging is too low, the number of non-operating node will increase. If the frequency of energy charging is too high, each node will waste too much time in the energy charging process. In order to maximize the overall ratio of operating time of the sensor nodes, the WCV and sensor nodes require a proper scheme for the energy charging process. In this paper, we propose an energy charging scheme that can maximize the ratio of operating time of the sensor nodes, and thus improve the performance of the sensor network.
Supplementary Figure 3 from Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 3:SCD1 inhibition induces ATF6 - PDF file 844K, ATF6 is activated in response to SCD1 inhibition in ccRCC&lt;/p&gt;
L-Arginine Ameliorates the Abnormal Sympathetic Response of the Dysfunctional Human Coronary Microvasculature (2004)

A nitric oxide (NO)-related defect may contribute to abnormal coronary sympathetic responses that can cause ischemia in patients with endothelial dysfunction. Because L-arginine, the NO synthase (NOS) precursor, augments NO bioactivity, we hypothesized that L-arginine would improve dysfunctional coronary sympathetic responses. Eleven patients with atherosclerosis or its risk factors were challenged with the cold pressor test, a specific provocative test of cardiac sympathetic activity, after 3 separate and sequential intracoronary infusions, as follows: 1) Normal saline; 2) L-NMMA, a competitive inhibitor of NOS; and 3) L-arginine. Study patients exhibited abnormal microvascular responses with coronary vascular resistance (CVR) increasing by 22.3 +/- 9.7% (mean +/- 1 SEM), p < 0.01. In addition, the change in coronary blood flow (CBF) did not correlate with the change in rate pressure product (RPP), r = -0.29, p = NS, suggesting an uncoupling of CBF from cardiac work. In the presence of L-NMMA, the CVR response, 10.3 +/- 9.8%, did not differ from the baseline response, and there was no relationship between the changes in CBF and RPP, r = 0.13, p = NS. In contrast, L-arginine ameliorated the CVR response, -3.2 +/- 3.1%, p < 0.05 vs baseline response, and restored the normal correlation between the changes in CBF and RPP, r = 0.74, p < 0.01. L-arginine not only improved abnormal microvascular responses to sympathetic activation, but it also restored the coupling that normally exists between coronary blood flow and cardiac work. L-arginine warrants further investigation as a therapy for coronary artery disease.
Video-Game Play Induces Plasticity in the Visual System of Adults with Amblyopia (2011)

ClinicalTrials.gov NCT01223716.
Combined fibre-optic sensor for colour and refractive index (CI) monitoring (2006)

Two fibre-optic probes are combined for the simultaneous monitoring of colour and refractive index of liquids, including highly coloured ones. It is shown how, through modelling, the design can be adapted to cover different ranges of refractive index, light absorption and sensitivity.
S0768 Early and Durable Symptom Control in Patients With Moderately to Severely Active Ulcerative Colitis Treated With Etrasimod (APD334) in the Phase 2 OASIS Trial and Open Label Extension (2020)

INTRODUCTION: Etrasimod is a once daily, oral, selective sphingosine 1-phosphate receptor modulator that demonstrated efficacy in the 12-week OASIS trial (NCT02447302) in adult patients with moderately to severely active UC. Patients completing OASIS were eligible to enroll in an OLE (NCT02536404) and received etrasimod 2 mg QD for up to 52 weeks. METHODS: We evaluated the association between improvement in PROs of rectal bleeding (RB) and stool frequency (SF)4 and clinical and endoscopic response at EOT in patients receiving open label etrasimod 2 mg. We calculated least squares mean reductions in RB and SF over time in patients receiving etrasimod 2 mg (n = 49) or placebo (PBO; n = 52) in the DB study and mean reductions in RB and SF over time in patients receiving etrasimod 2 mg throughout the DB study and OLE (treat-through [TT] group, n = 31). Analyses included patients with non-missing assessments and used Mayo subscores (0–3). Endoscopic improvement was defined as asubscore ≤1; Remission was defined as endoscopic improvement + RB score ≤1, and SF score ≤1 with ≥1 point decrease from baseline; Response was defined as a decrease in the modified Mayo score (endoscopy, RB, SF) of ≥2 and ≥30%, with RB score ≤1 or ≥1 decrease from baseline. RESULTS: During the DB study, patients receiving etrasimod 2 mg vs PBO had a significantly greater reduction in RB at Wk2 (0.55 vs 0.26; P < .05) that continued through Wk12 (0.97 vs 0.63; P < .05). Etrasimod 2 mg group vs PBO had a numerically greater reduction in SF as early as Wk2 (0.33 vs 0.22; P > .05) that continued to Wk12 (0.74 vs 0.61; P > .05). At EOT, etrasimod 2 mg TT group had maintained reductions of RB or SF compared with Wk12 (change from Wk12 to EOT in RB and SF: 0.0 and 0.1). In etrasimod 2 mg TT group, reductions in RB and SF at 2 weeks were greater in patients with clinical response or clinical remission at EOT vs without (Table). Reduction in SF was greater in patients in TT group who had endoscopic improvement at EOT vs those who did not. CONCLUSION: Patients with UC who received etrasimod 2 mg in the OASIS trial had early clinical improvements seen as soon as Wk2. Early responders experienced superior clinical and endoscopic improvement at the end of the OLE compared with delayed responders.Table 1
Photoelectron spectroscopy of f element organometallic complexes. 11. An investigation of the electronic structure of some tris(.eta.5-cyclopentadienyl)thorium(IV) and -uranium(IV) complexes by relativistic effect core potential ab initio calculations and gas-phase UV photoelectron spectroscopy (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectroscopy of f element organometallic complexes. 11. An investigation of the electronic structure of some tris(.eta.5-cyclopentadienyl)thorium(IV) and -uranium(IV) complexes by relativistic effect core potential ab initio calculations and gas-phase UV photoelectron spectroscopySanto Di Bella, Antonino Gulino, Giuseppe Lanza, Ignazio L. Fragala, and Tobin J. MarksCite this: J. Phys. Chem. 1993, 97, 45, 11673–11676Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/j100147a020https://doi.org/10.1021/j100147a020research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Solving the 90% Infrastructure Energy Challenge for Passenger Electric Vehicles (2022)

Based on actual daily driving data, about 90% of passenger electric vehicle energy needs, both in the U.S. and in China, can be supported by charging from conventional single-phase outlets. This represents about half of all transportation energy, once the transition to electricity is complete. Basic outlet infrastructure is far cheaper and more scalable than the faster infrastructure emphasized in much present work. Comparisons are made to show how basic outlets can serve as critical electrification infrastructure. The vehicles themselves can support measurement, metering, and communication for billing and for grid flexibility. A vehicle owner can choose to support limited flexibility, controlled by the vehicle itself, to track for minimum energy pricing. Alternatively, for even lower prices, a vehicle owner could allow a grid operator or aggregator to modulate charging and support dynamic grid services. The work shows how infrastructure in a city can scale to millions of energy access points.
An automatic image processing algorithm for initiating and terminating intracoronary  OFDI pullback (2010)

Intracoronary optical frequency domain imaging (OFDI) provides high resolution, three-dimensional views of coronary artery microstructure, but requires a non-occlusive saline/contrast purge to displace blood for clear artery views. Recent studies utilized manual pullback initiation/termination based on real-time image observation. Automated pullback initiation/termination by real-time OFDI signal analysis would enable more efficient data acquisition. We evaluate the use of simple imaging parameters to automatically and robustly differentiate between diagnostic-quality clear artery wall (CAW) versus blood-obstructed fields (BOF). Algorithms are tested using intracoronary OCT human data retrospectively and intracoronary OFDI swine and human data prospectively. In prospective analysis of OFDI swine data, the sensitivity and specificity of the ratio of second and first moments (contrast parameter) were 99.6% and 97.2%, respectively. In prospective analysis of OFDI clinical data, the contrast parameter yielded 96.0% sensitivity and 94.5% specificity. Accuracy improved further by analyzing sequential frames. These results indicate the algorithm may be utilized with intracoronary OFDI for initiating and terminating automated pullback and digital data recording.
Echocardiographic pitfalls in the diagnosis of hypertrophic cardiomyopathy (1999)

The diagnosis of hypertrophic cardiomyopathy (HCM) can often be difficult. Traditionally, it has been a diagnosis of exclusion, requiring the demonstration of left ventricular hypertrophy (LVH) in the absence of other causes, such as systemic hypertension or aortic stenosis.1 2 Early reports focused on the presence of asymmetrical hypertrophy with an outflow tract gradient (hence the acronym HOCM) but it has become clear that this is not the most common appearance.3-7 Furthermore, recent reports of genotypically affected individuals without hypertrophy, who are nevertheless at risk of sudden death,8 further complicate the situation. Recently, McKenna and colleagues9 proposed modified criteria for the diagnosis of HCM, which overcome some of the problems associated with the conventional criteria (table 1). The new proposed criteria highlight the importance of a comprehensive family history and 12 lead electrocardiogram (ECG) over the echocardiogram in the diagnosis of HCM. Even then, extreme care must be taken because systematic family screening programmes have identified patients who are phenotypically normal but have affected siblings and offspring. These carriers can be missed and their progeny miscoded with less rigorous protocols. Diagnosis can only be 100% reliable when all the implicated gene loci have been identified. Until then the combination of ECG and echocardiography, in conjunction with other clinical information, remain the most useful tests for the diagnosis of patients with HCM. Here, we discuss some of the pitfalls encountered in the echocardiographic evaluation of HCM.

View this table:

Table 1 
Echocardiographic pitfalls



As a rule, patients with HCM have a considerably increased left ventricular wall thickness, an echocardiographic marker of ventricular hypertrophy, with a small non-compliant but apparently well contracting left ventricle. Early M mode echocardiographic studies defined the characteristic features as asymmetrical hypertrophy of the ventricular septum, with or without systolic anterior motion of the mitral valve, and premature closure …
Abstract 3071: VERU-111, a novel orally bioavailable tubulin inhibitor, overcomes taxane resistance in metastatic triple-negative breast cancer (2020)

Abstract Triple-negative breast cancer (TNBC) has aggressive clinical features strongly associated with poorer overall prognosis and higher mortality rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly observed due to the development of acquired chemoresistance, which remains a clinical challenge for TNBC therapy. We have shown that orally administered VERU-111 inhibits MDA-MB-231 xenograft growth with similar efficacy to paclitaxel, but without acute toxicity, and represses metastases originating from the mammary fat pad. To better understand the effect of VERU-111 on taxane-resistant TNBC, we generated a panel of paclitaxel-resistant TNBC sublines (MDA-MB-231/TxR, MDA-MB-468/TxR, SUM159/TxR and Hs578T/TxR) by gradually exposing paclitaxel to parental lines. MTS assays were used to confirm the chemoresistance of each subline to paclitaxel. VERU-111 maintained its potency against all four taxane-resistant sublines. We further investigated the underlying mechanisms of VERU-111 action and found that it inhibited taxane-resistant TNBC cell proliferation by inducing mitotic arrest and apoptosis via disruption of microtubule stability. In vivo, relative to paclitaxel, VERU-111 significantly inhibited tumor growth in an orthotopic MDA-MB-231/TxR model and reduced lung metastases originating from the mammary fat pad. VERU-111 induced tumor necrosis, anti-angiogenesis and apoptosis in both taxane-sensitive and taxane-resistant TNBC models in vivo. In addition to the MDA-MB-231/TxR model, we also tested the efficacy of VERU-111 in a multidrug-resistant PDX model, HCI-10. VERU-111 significantly inhibited HCI-10 primary tumor growth and suppressed the growth of lymph node metastases present prior to therapy and suppressed lung, liver and kidney metastases at the endpoint. In contrast, paclitaxel had no efficacy to repress tumor growth or metastasis in this model, and in fact, stimulated liver metastasis. Taken together, our data demonstrate that VERU-111 is a new generation of oral tubulin inhibitor that potently inhibits the growth of taxane-sensitive and taxane-resistant TNBC. Therefore, VERU-111 therapy is a promising strategy for the treatment of metastatic TNBC patients, including those patients who progress on taxanes. Citation Format: Shanshan Deng, Raisa I. Krutilina, Deanna N. Parke, Hao Chen, Duane D. Miller, Tiffany N. Seagroves, Wei Li. VERU-111, a novel orally bioavailable tubulin inhibitor, overcomes taxane resistance in metastatic triple-negative breast cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3071.
Supplementary Figure 4 from Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1 (2023)

Supplementary Figure 4 from Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
Subject-level measurement of local cortical coupling (2016)

The human cortex is highly folded to allow for a massive expansion of surface area. Notably, the thickness of the cortex strongly depends on cortical topology, with gyral cortex sometimes twice as thick as sulcal cortex. We recently demonstrated that global differences in thickness between gyral and sulcal cortex continue to evolve throughout adolescence. However, human cortical development is spatially heterogeneous, and global comparisons lack power to detect localized differences in development or psychopathology. Here we extend previous work by proposing a new measure - local cortical coupling - that is sensitive to differences in the localized topological relationship between cortical thickness and sulcal depth. After estimation, subject-level coupling maps can be analyzed using standard neuroimaging analysis tools. Capitalizing on a large cross-sectional sample (n=932) of youth imaged as part of the Philadelphia Neurodevelopmental Cohort, we demonstrate that local coupling is spatially heterogeneous and exhibits nonlinear development-related trajectories. Moreover, we uncover sex differences in coupling that indicate divergent patterns of cortical topology. Developmental changes and sex differences in coupling support its potential as a neuroimaging phenotype for investigating neuropsychiatric disorders that are increasingly conceptualized as disorders of brain development. R code to estimate subject-level coupling maps from any two cortical surfaces generated by FreeSurfer is made publicly available along with this manuscript.
We Grew up Together: Brothers and Sisters in Nineteenth-Century America (2001)

Journal Article We Grew Up Together: Brothers and Sisters in Nineteenth-Century America Get access We Grew Up Together: Brothers and Sisters in Nineteenth-Century America. By Atkins Annette. (Urbana: University of Illinois Press, 2001. xviii +194 pp. Notes, bibliography, index. $29.95.) Jessie L. Embry Jessie L. Embry Brigham Young University Search for other works by this author on: Oxford Academic Google Scholar Western Historical Quarterly, Volume 32, Issue 4, Winter 2001, Pages 509–510, https://doi.org/10.2307/3650812 Published: 01 November 2001
COMMON WORD ERRORS (2008)

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Efficient searchable encryption through compression (2018)

In this work we design new searchable encryption schemes whose goal is to minimize the number of cryptographic operations required to retrieve the result---a dimension mostly overlooked by previous works, yet very important in practice. Our main idea is to utilize compression so as to reduce the size of the plaintext indexes before producing the encrypted searchable indices. Our solution can use any existing Searchable Encryption (SE) scheme as a black-box and any combination of lossless compression algorithms, without compromising security. The efficiency of our schemes varies based on the leakage exposed by the underlying application. For instance, for private keyword search (more leakage), we demonstrate up to 188× savings in search time, while for database search (less leakage) our savings are up to 62×. The power of our approach is better manifested when combined with more secure, yet less practical, cryptographic tools, such as Oblivious Random Access Memory (ORAM). In particular while ORAM is known to be prohibitively expensive for large-scale applications, we show that our compress-first-ORAM-next approach allows significant more efficient index search time, reducing the time for executing a query with result of size more than one million tuples from approximately 21 hours to 20 minutes.