gebhart/patrepeval huggingface dataset:
Matrix Isolation of Germacyclopentadienes:  Direct Spectroscopic Evidence for Germylene-to-Germene Photochemical Interconversion (1996)

UV irradiation of matrix-isolated 1,1-diazido-1-germacyclopent-3-ene (4b) produced 1H-germole (1-germacyclopenta-2,4-diene; 1b) and 1-germacyclopent-3-ene-1,1-diyl (2b) as major products along with 3H-germole (1-germacyclopenta-1,4-diene; 5b) and 2H-germole (1-germacyclopenta-1,3-diene; 6b) as minor products. During irradiation at selected wavelengths a photoconversion of 1b into 5b and reversible interconversion of 2b and 6b have been observed and provide experimental evidence for a germylene-to-germene rearrangement. Similar experiments were carried out on deuterated analogues, and the precursor 4b-d6 produced 1b-d6, 2b-d6, 5b-d6, and 6b-d6. Full vibrational assignment in the IR spectra of 1b, 2b, 5b, and 6b has been proposed on the basis of restricted Hartree−Fock (DZ+d) calculations for those molecules and their d6 analogues and literature data on the silicon analogues 1a, 2a, 5a, 6a, and other related molecules. The UV−vis spectra are interpreted by comparison with the experimental and computed transition energies of the silacyclopentadiene isomers 1a, 2a, 5a, and 6a. The GeC stretching frequencies are low and provide evidence for CGeCC and GeCCC π conjugation, which is somewhat weaker than that established earlier in the silacyclopentadienes 5a and 6a.
Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation (2022)

Parkinson's disease is characterized by the aggregation of the presynaptic protein α-synuclein (αSyn), and its co-assembly with lipids and other cellular matter in the brain. Here we investigated lipid-protein co-assembly in a system composed of αSyn and model membranes containing the glycolipid ganglioside GM3. We quantified the uptake of lipids into the co-assembled aggregates and investigated how lipid molecular dynamics is altered by being present in the co-assemblies using solution <sup>1</sup>H- and solid-state <sup>13</sup>C NMR spectroscopy. Aggregate morphology was studied using cryo-TEM. The overall lipid uptake in the co-assembled aggregates was found to increase with the molar ratio of GM3 in the vesicles. The lipids present in the co-assembled aggregates have reduced acyl chain and headgroup dynamics compared to the protein-free bilayer system. These findings may improve our understanding of how different types of lipids can influence the composition of αSyn aggregates, which may have consequences for amyloid formation in vivo.
Serum Response Factor Cleavage by Caspases 3 and 7 Linked to Apoptosis in Human BJAB Cells (2001)

Apoptosis involves the cessation of cellular processes, the breakdown of intracellular organelles, and, finally, the nonphlogistic clearance of apoptotic cells from the body. Important for these events is a family of proteases, caspases, which are activated by a proteolytic cleavage cascade and drive apoptosis by targeting key proteins within the cell. Here, we demonstrate that serum response factor (SRF), a transcription factor essential for proliferative gene expression, is cleaved by caspases and that this cleavage occurs in proliferating murine fibroblasts and can be induced in the human B-cell line BJAB. We identify the two major sites at which SRF cleavage occurs as Asp(245) and Asp(254), the caspases responsible for the cleavage and generate a mutant of SRF resistant to cleavage in BJAB cells. Investigation of the physiological and functional significance of SRF cleavage reveals that it correlates with the loss of c-fos expression, whereby neither SRF cleavage fragment retains transcriptional activity. Moreover, the expression of a noncleavable SRF in BJAB cells suppresses apoptosis induced by Fas cross-linking. These results suggest that for apoptosis to proceed, the transcriptional events promoting cell survival and proliferation, in which SRF is involved, must first be inactivated.
Link-Level Analysis of Downlink Handover Regions in UMTS (2008)

This paper investigates the downlink handover (soft/softer/hard) performance of wideband code division multiple access (WCDMA) based 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> generation universal mobile telecommunication system (UMTS), as it is known that the downlink capacity of UMTS is very sensitive to the extent of overlap area between adjacent cells and power margin between them. Factors influencing the handover performance such as the correlation between the multipath radio channels of the two links, limiting number of Rake fingers in a handset, imperfect channel estimation, etc. that cannot be modeled adequately in system-level simulations are investigated via link-level simulations. It is also shown that the geometry factor has an influence on the handover performance and exhibits a threshold value (which depends on the correlation between the multipath channels associated with the two links in a handover) above which the performance starts degrading. The variation of the handover gain with the closed loop power control (CLPC) step-size and space-time transmit diversity (STTD) is also quantified. These comprehensive results can be used as guidelines for more accurate coverage and capacity planning of UMTS networks.
Utilization of Sugarcane Bagasse as a Substrate for Lipid Production by <i>Aurantiochytrium</i> sp. (2022)

Thraustochytrid, Aurantiochytrium sp., produces various lipids such as polyunsaturated and saturated fatty acids, carotenoids, and other hydrocarbons, which are useful in the fields of health foods, cosmetics, fine chemicals, and biofuels. Lignocellulosic biomass, which is abundant and cheap, is a promising feedstock for producing cheaper bulk and high-value-added products using Aurantiochytrium sp. However, the steam explosion of lignocellulosic biomass for efficient enzymatic saccharification generates substances that inhibit the growth of microorganisms. In this study, the inhibitory activities of these by-products on the growth and lipid production of Aurantiochytrium sp. were investigated. Aurantiochytrium sp. was found to be highly sensitive to furfural and vanillin and moderately sensitive to 5-hydroxymethylfurfural and syringaldehyde. Washing steam-exploded bagasse with water, followed by activated charcoal treatment, significantly reduced furfural, which was a major inhibitory component in the saccharified solution.
Out-of-Plane Mechanical Properties of 2D Hybrid Organic-Inorganic Perovskites by Nanoindentation (2018)

2D layered hybrid organic-inorganic perovskites (HOIPs) have demonstrated improved stability and promising photovoltaic performance. The mechanical properties of such functional materials are both fundamentally and practically important to achieve both high performance and mechanical stable (flexible) devices. Here we report the mechanical properties of a series of 2D layered lead iodide HOIPs and investigate the role of structural sub-units (e.g., variation of the length of the organic spacer molecules -R and the number of inorganic layer -n) on the mechanical properties. While 2D HOIPs have much lower nominal elastic moduli and hardness than 3D HOIPs, larger n number and shorter R lead to stiffer materials. DFT simulations showed a similar trend to the experimental results. We compared these findings with other 2D layered crystals and shed light on routes to further tune the out-of-plane mechanical properties of 2D layered HOIPs.
Radiofrequency ablation of lymphoma (2005)

Percutaneous minimally invasive radiofrequency (RF) ablation has not been described for lymphoma. This image-guided modality is presented in 3 different settings for the treatment of refractory lymphoma. The first patient received RF ablation for the curative treatment of a solitary residual hepatic mass following rituximab-based chemotherapy for a posttransplantation lymphoproliferative disorder (PTLD) and is disease-free 4 years later. The second patient received RF ablation for successful palliation of progressive follicular lymphoma adjacent to the bladder wall following chemotherapy and maximum radiation. The third patient received RF ablation for prevention of airway obstruction from progressive diffuse large B-cell lymphoma of the right neck following chemotherapy and maximum radiation. RF ablation may be clinically beneficial and should be considered for the treatment of local lymphoma that is refractory or not amenable to standard approaches.
Infrared Band Broadening and Interactions in Polar Systems (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTInfrared Band Broadening and Interactions in Polar SystemsPaul C. Painter, George J. Pehlert, Yuhong Hu, and Michael M. ColemanView Author Information Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 19802 Cite this: Macromolecules 1999, 32, 6, 2055–2057Publication Date (Web):February 25, 1999Publication History Received9 September 1998Published online25 February 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/ma981422khttps://doi.org/10.1021/ma981422kbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views321Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbonyls,Molecular interactions,Molecular structure,Molecules,Organic compounds Get e-Alerts
End-to-end evaluation of practical video analytics systems for face detection and recognition (2023)

Practical video analytics systems that are deployed in bandwidth constrained environments like autonomous vehicles perform computer vision tasks such as face detection and recognition. In an end-to-end face analytics system, inputs are first compressed using popular video codecs like HEVC and then passed onto modules that perform face detection, alignment, and recognition sequentially. Previously, the modules of these systems have been evaluated independently using task-specific imbalanced datasets that can misconstrue performance estimates. In this paper, we perform a thorough end-to-end evaluation of a face analytics system using a driving-specific dataset, which enables meaningful interpretations. We demonstrate how independent task evaluations and dataset imbalances can overestimate system performance. We propose strategies to balance the evaluation dataset and to make its annotations consistent across multiple analytics tasks and scenarios. We then evaluate the end-to-end system performance sequentially to account for task interdependencies. Our experiments show that our approach provides a true estimate of the end-to-end performance for critical real-world systems.
On wafer pattern measurements of integrated antennas on standard BiCMOS and glass processes for 40-80 GHz applications (2005)

International audience
A statistical language modeling approach integrating local and global constraints (2002)

A new framework is proposed to integrate the various constraints, both local and global, that are present in language. Local constraints are captured via n-gram language modeling, while global constraints are taken into account through the use of latent semantic analysis. An integrative formulation is derived for the combination of these two paradigms, resulting in several families of multi-span language models for large-vocabulary speech recognition. Because of the inherent complementarity in the two types of constraints, the performance of the integrated language models, as measured by perplexity, compares favorably with the corresponding n-gram performance.
Analysis of the metal‐binding selectivity of the metallochaperone CopZ from Enterococcus hirae by electrospray ionization mass spectrometry (2003)

Metallochaperones are soluble proteins involved in metal transport and regulation in vivo. Copper metallochaperones belong to a structural family of metal binding domains displaying a ferredoxin-like fold (betaalphabetabetaalphabeta) and a consensus metal-binding motif MXCXXC. The metal-binding selectivities for this class of proteins are poorly documented so far. The present study focuses on the measurement of the selectivity of the copper metallochaperone CopZ from Enterococcus hirae for different metal ions using an experimental approach based on electrospray ionization mass spectrometry (ESI-MS). All the metal cations tested, i.e. Cu(I), Cu(II), Hg(II), Cd(II) and Co(II), form specific metal complexes with CopZ. The study of a chemically modified CopZ as well as variants of CopZ in the active site demonstrated that the complexes observed by ESI-MS, i.e. in the gas phase, corresponded to the complexes previously observed by other analytical methods in solution. Competition experiments allowed the classification of the metal ions by increasing affinities for CopZ as follows: Co << Cd < Hg < Cu. A dissociation constant in the range of 20 microM was determined for cobalt. The affinity of CopZ for the other metals tested was found to be higher, with dissociation constants smaller than micromolar.
Safety of Multiple Vaccinations and Durability of Vaccine-Induced Antibodies in an Italian Military Cohort 5 Years after Immunization (2021)

We previously examined the safety and immunogenicity of multiple vaccines administered to a military cohort, divided into two groups, the first composed of students at military schools, thus operating inside the national borders for at least 3 years, and the other formed of soldiers periodically engaged in a 9-month-long mission abroad (Lebanon). In the current study, we analyzed 112 individuals of this cohort, 50 pertaining to the first group and 62 to the second group, in order to examine the possible late appearance of side effects and to calculate the half-life of the induced antibodies. Moreover, the possible involvement of B-cell polyclonal activation as a pathogenetic mechanism for long term antibody persistence has even been explored. No late side effects, as far as autoimmunity and/or lymphoproliferation appearance, have been noticed. The long duration of the vaccine induced anti-HAV antibodies has been confirmed, whereas the antibodies induced by tetravalent meningococcal polysaccharide vaccine have been found to persist above the threshold for putative protection for a longer time, and anti-tetanus, diphtheria, and polio 1 and 3 for a shorter time than previously estimated. No signs of polyclonal B-cell activation have been found, as a possible mechanism to understand the long antibody persistence.
Supplemental Figure 4 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer (2023)

&lt;p&gt;Supplemental Figure 4&lt;/p&gt;
Preparation and Transport Properties of TlBa2Ca2Cu3Oy Thin Films by Metalorganic Deposition (1993)

Thin films of the TlBa 2 Ca 2 Cu 3 O y (Tl-(1223)) system were successfully prepared on SrTiO 3 (100) substrates by means of the deposition of a Ba-Ca-Cu-O precursor by the metalorganic deposition (MOD) method with the reaction of Tl 2 O 3 vapor. The films (1 µm thickness) were composed entirely of the (1223) phase and had a highly c -axis-oriented structure. The films had T c zero =106 K and showed a high transport critical current ( I c ) of 6.3 A with a 1-mm-wide bridge, which corresponds to the transport critical current density ( J c ) of 6.3×10 5 A/cm 2 at 77 K in a zero magnetic field. When the magnetic field was applied perpendicular to the a-b plane, the J c values were 2.0×10 4 and 6.0×10 5 A/cm 2 at 77 and 40 K in a 1 T field, respectively. Moreover, the history effect of J c in the magnetic field was not observed at 77 K below 0.1 T. These results indicate that the Tl-(1223) film, formed by the MOD method, has strong magnetic flux pinning characteristics and good intergranular connectivity.
Symposium (2019)

The intent of the symposium is to provide a forum for discussion about what it is like to try to “do” cognitive science in settings involving real products, real customers, and other constraints in which the bottom line is not necessarily to produce a pristine test of a theory but rather, to compete in the marketplace or perhaps save a life. Cognitive science is full of interesting and complex theories. People have surprising difficulty in retrieving relevant information from external sources. Anyone who has looked for something in the index of a book, the Yellow Pages, or in computer databases has experienced this problem. Using cognitive modeling to predict human performance in real-world settings is an enterprise laden with paradox. If cognitive models predict human performance with computer systems that the system designers consider “intuitive,” then modeling is perceived to be of little value.
A scale model for fitting object shapes from fixed location data (2004)

In this paper we present a scale model for fitting an ideal shape to an object. The measurements of the object are taken corresponding to a fixed coordinate system at a set of well-defined locations on the surface of the object. We propose an algorithm to estimate the model parameters and hypothesis tests to make statistical inferences about several possible special cases of the general model. The model is tested with an example that analyzes data on the feet of people in Hong Kong.
Building community for deaf scientists (2017)

Article MetricsDownloadsCitationsNo data available.01234AugSepOctNovDecJan1230Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Dispersion characteristics of fiber Bragg gratings with Gaussian self apodization made with a femtosecond laser in heavily doped Erbium and Ytterbium fibers (2007)

Short fiber lasers are increasingly studied due to their applications in communications and sensing<sup>1</sup>. These lasers require high concentrations of Erbium (Er) and Ytterbium (Yb) that are not compatible with the presence of Germanium (Ge) in the fiber core<sup>2</sup>. In stark contrast with more conventional fabrication methods, ultrafast lasers now allow for grating inscription within fibers having no Ge doping<sup>3</sup>. Normally for short gratings the reflected signal dispersion is small and relatively harmless to the operation of long cavities. As cavity length decreases however the signal will tend to travel more and more within the gratings, interacting with them proportionately more often. Hence a thorough understanding of the grating dispersion characteristics becomes even more important. As a result of their physical differences, the characteristics of ultrafast gratings can vary substantially from those produced using more conventional fabrication methods, and it is unknown whether these factors in combination with a high dopant concentration will significantly affect the dispersion properties of such gratings. In this study, Bragg gratings made with infrared (IR) femtosecond radiation and a first order phase mask were inscribed in fibers heavily doped with Er and Yb as well as a pure silica core fiber. Subsequent measurements of the power spectra, group delay and group delay ripple (GDR) are reported herein.
ChemInform Abstract: Remarkable Enhancement of Binding Affinity of Heterocycle‐Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2‐Imidazolylpropylguanine and N2‐Imidazolylpropyl‐2‐aminoadenine Modified Oligonucleotides. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antibody evolution immunogens (2023)

The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
Ética en la Investigación: Buenas prácticas científicas (2015)

La integridad cientifica es un presupuesto esencial para el progreso y el avance del conocimiento. Las malas practicas cientificas -fabricacion, falsificacion y plagio-, asi como las conductas cuestionables perjudican a la investigacion, generan perdida de confianza entre cientificos, entre estos y la sociedad, y danan la imagen publica de la ciencia. Los agentes implicados deben promover la buena praxis en investigacion mediante acciones formativas en integridad cientifica, y la formulacion de principios y recomendaciones en codigos de buenas practicas. En este articulo se trataran las malas practicas cientificas, sus causas, incidencia, y efectos, asi como acciones planteadas a nivel institucional e internacional para combatirlas.
Millimeter-wave measurements of molecular spectra with application to environmental monitoring (1996)

This paper presents results of mm-wave spectral properties of chemicals in the 225-315 GHz frequency range at ambient atmospheric pressure. The effect of pressure broadening of the spectral lines is determined by both experiments and theoretical simulation. Subsequent to the laboratory measurements, the proof of the principle of the open-path monitoring of airborne chemicals was tested by using a monostatic swept-frequency radar system.
Supplementary Fig S2 from Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer (2023)

&lt;p&gt;- PDF file 108K, Supplementary Figure S2. mRNA and Protein Expression in BNC1 Overexpression System&lt;/p&gt;
An Equipment for Voltage-Transducers Calibration Oriented to the Uncertainty Estimate in DSP-Based Measurements (2007)

Nominal accuracy specifications of voltage transducers cannot be used to determine the uncertainty affecting the instantaneous values of the output signals; hence, the uncertainty in the measurements performed by DSP-based instruments cannot be estimated. A programmable equipment, which is designed to solve such a problem and which implements the characterization procedure of analog-signal conditioning blocks described in a previous contribution, is presented in this paper. The uncertainty sources located in the hardware of the setup are analyzed, and their effects on the measurement results are evaluated. Finally, on the basis of the equipment metrological characterization, the performance of the implemented methodology is discussed.