gebhart/patrepeval huggingface dataset:
The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes (1993)

hXBP-1 is a transcription factor of the leucine zipper (b-zip) family important in the expression of the class II major histocompatibility complex gene, DRA. Studies with mouse-human hybrids have mapped hXBP-1 hybridizing fragments to human chromosomes 5 and 22 and the frequent detection of two mRNA transcripts suggested that hXBP-1 may be a member of a small gene family. To analyze the structure and regulation of hXBP-1 further, cosmid clones from both chromosomes were isolated. Mapping and sequence analyses reveal that chromosome 22 contains the functional hXBP-1 gene while chromosome 5 contains a processed pseudogene. hXBP-1 promoter analysis has revealed that cis-active elements within the 5'-untranslated region of hXBP-1 are essential for full promoter activity. One such element, hX2, is identical to the hXBP-1 target sequence in the DRA promoter. Mutagenesis of the hX2 site substantially decreases promoter activity. This element interacts with four distinct protein complexes in mature B cells and cross-competition experiments show that two of these complexes (complex 1 and complex 4) also interact with the hXBP-1 target sequence (X2) from the DRA promoter. The similarities of the hXBP-1 promoter and of the DRA promoter (the gene that the hXBP-1 protein regulates) are further emphasized by the fact that a Y box element is located 3' of both hX2 and X2.
High-performance GaAs-based metal–oxide–semiconductor heterostructure field-effect transistors with atomic-layer-deposited Al2O3gate oxide and in situ AlN passivation by metalorganic chemical vapor deposition (2014)

GaAs-based metal–oxide–semiconductor heterostructure field-effect transistors (MOSHFETs) with Al2O3 gate oxide and in situ AlN passivation were investigated. Passivation with AlN improved the quality of the MOS interfaces, leading to good control of the gate. The devices had a sufficiently small subthreshold swing of 84 mV decade−1 in the drain current vs gate voltage curves, as well as negligible frequency dispersions and nearly zero hysteresis in the gate capacitance vs gate voltage curves. A maximum drain current of 630 mA/mm and a peak effective mobility of 6720 cm2 V−1 s−1 at a sheet carrier density of 3 × 1012 cm−2 were achieved.
Monoadducts of imido alkylidene complexes, syn and anti rotamers, and alkylidene ligand rotation (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonoadducts of imido alkylidene complexes, syn and anti rotamers, and alkylidene ligand rotationRichard R. Schrock, William E. Crowe, Guillermo C. Bazan, Marcello DiMare, Marie B. O'Regan, and Mark H. SchofieldCite this: Organometallics 1991, 10, 6, 1832–1843Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/om00052a033https://doi.org/10.1021/om00052a033research-articleACS PublicationsRequest reuse permissionsArticle Views562Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fluorescence headlights proposed for minimally-invasive surgical tools (Conference Presentation) (2020)

Early stages and the margins of disease can be invisible to human vision during surgical interventions. Molecular probes with fluorescence labeling are used to enhance contrast of lesions to distinguish their location and extent. However, low intensity fluorescence signals are problematic because photobleaching permanently loses this critical information. By using low power illumination from a scanning fiber endoscope (SFE), the rate of information loss is reduced by over 6x in glioma mouse model using 5ALA-PpIX compared to a clinical surgical microscope. We propose using one or more SFEs as headlights near the tip of surgical tools to guide interventions.
Data from A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti–Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Nesvacumab (REGN910) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Ang2 with high affinity, but shows no binding to Ang1. The main objectives of this trial were to determine the safety, tolerability, dose-limiting toxicities (DLT), and recommended phase II dose (RP2D) of nesvacumab.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Nesvacumab was administered intravenously every two weeks with dose escalations from 1 to 20 mg/kg in patients with advanced solid tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; A total of 47 patients were treated with nesvacumab. No patients in the dose escalation phase experienced DLTs, therefore a maximum tolerated dose (MTD) was not reached. The most common nesvacumab-related adverse events were fatigue (23.4%), peripheral edema (21.3%), decreased appetite, and diarrhea (each 10.6%; all grade ≤ 2). Nesvacumab was characterized by linear kinetics and had a terminal half-life of 6.35 to 9.66 days in a dose-independent manner. Best response by RECIST 1.1 in 43 evaluable patients included 1 partial response (adrenocortical carcinoma) of 24 weeks duration. Two patients with hepatocellular carcinoma had stable disease (SD) &gt; 16 weeks, with tumor regression and &gt;50% decrease in α-fetoprotein. Analyses of putative angiogenesis biomarkers in serum and tumor biopsies were uninformative for treatment duration.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Nesvacumab safety profile was acceptable at all dose levels tested. Preliminary antitumor activity was observed in patients with treatment-refractory advanced solid tumors. On the basis of cumulative safety, antitumor activity, pharmacokinetic and pharmacodynamic data, the 20 mg/kg dose was determined to be the RP2D. &lt;i&gt;Clin Cancer Res; 22(6); 1348–55. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Thermal characteristics of 1.3um InAs-based quantum-dot lasers on silicon substrates (Conference Presentation) (2019)

We investigate the temperature and pressure dependence of a series of intrinsic and modulation p-doped InAs-based dot-in-well (DWELL) laser diodes grown on silicon substrates. Temperature dependence of the threshold current density (Jth) and pure spontaneous emission spectra provide an insight into inhomogeneity and non-radiative recombination mechanisms within the devices. Initial investigations showed that the intrinsic devices exhibited low temperature sensitivity in the range 170-200K. Above this, Jth increased more rapidly consistent with Auger recombination. P-doping increased the temperature at which Jth(T) started to increase up to 300K with a temperature insensitive region close to room temperature. P-doping delays the onset of carrier thermalization, leading to a high T0 but with an associated higher Jth. Temperature dependence of gain spectrum broadening was investigated by measuring the spontaneous emission spectral width parameter (1/e2) just below Jth (T). A strong direct correlation is found between the temperature dependence of peak width with the temperature dependence the radiative component of threshold, Jrad(T). At low temperature the correlation is consistent with strong inhomogeneous broadening of the carrier distribution. As temperature increases Jth reduces associated with carriers thermalizing to lower energy states. At higher temperatures homogeneous thermal broadening coupled with non-radiative recombination causes Jth to increase. Inhomogeneous broadening is more pronounced in the p-doped devices due to coulombic attraction between acceptor holes and injected electrons. A detailed analysis of recombination processes using high hydrostatic pressure and spontaneous emission in these lasers as a function of doping density will be presented and discussed at the conference.
Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β) (2009)

The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described. Hit-generation chemistry based on IKK-beta active-site knowledge yielded a weakly potent but tractable chemotype that was rapidly progressed into a series with robust enzyme and cellular activity and significant selectivity over IKK-alpha.
The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response inDrosophila (2016)

Ninein (Nin) is a centrosomal protein whose gene is mutated in Seckel syndrome (SCKL, MIM 210600), an inherited recessive disease that results in primordial dwarfism, cognitive deficiencies, and increased sensitivity to genotoxic stress. Nin regulates neural stem cell self-renewal, interkinetic nuclear migration, and microtubule assembly in mammals. Nin is evolutionarily conserved, yet its role in cell division and development has not been investigated in a model organism. Here we characterize the single Nin orthologue in Drosophila Drosophila Nin localizes to the periphery of the centrosome but not at centriolar structures as in mammals. However, Nin shares the property of its mammalian orthologue of promoting microtubule assembly. In neural and germline stem cells, Nin localizes asymmetrically to the younger (daughter) centrosome, yet it is not required for the asymmetric division of stem cells. In wing epithelia and muscle, Nin localizes to noncentrosomal microtubule-organizing centers. Surprisingly, loss of nin expression from a nin mutant does not significantly affect embryonic and brain development, fertility, or locomotor performance of mutant flies or their survival upon exposure to DNA-damaging agents. Although it is not essential, our data suggest that Nin plays a supportive role in centrosomal and extracentrosomal microtubule organization and asymmetric stem cell division.
The Hypercomputational Case for Substance Dualism (2010)

I'm a dualist; in fact, a substance dualist. Why? Myriad arguments compel me to believe as I do, some going back to Descartes. But some sound arguments for substance dualism are recent; and one of these, a new argument so far as I know, is given herein | one that exploits both the contemporary computational scene, and a long-established continuum of increasingly powerful computation, ranging from varieties \beneath" Turing machines to varieties well beyond them. This argument shows that the hypercomputational nature of human cognition implies that Descartes was right all along. Encapsulated, the implication runs as follows: If human persons are physical, then they are their brains (plus, perhaps, other central-nervous-system machinery; denote the composite object by `brains+'). But brains+, as most in AI and related fields correctly maintain, are information processors no more powerful than Turing machines. Since human persons hypercompute (i.e., they process information in ways beyond the reach of Turing machines), it follows that they aren't physical, i.e., that substance dualism holds. Needless to say, objections to this argument are considered and rebutted.
From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds (2017)

Bitter taste elicits an aversive reaction, and is believed to protect against consuming poisons. Bitter molecules are detected by the Tas2r family of G-protein-coupled receptors, with a species-dependent number of subtypes. Chickens demonstrate bitter taste sensitivity despite having only three bitter taste receptors-ggTas2r1, ggTas2r2 and ggTas2r7. This minimalistic bitter taste system in chickens was used to determine relationships between in-vitro (measured in heterologous systems) and in-vivo (behavioral) detection thresholds. ggTas2r-selective ligands, nicotine (ggTas2r1), caffeine (ggTas2r2), erythromycin and (+)-catechin (ggTas2r7), and the Tas2r-promiscuous ligand quinine (all three ggTas2rs) were studied. Ligands of the same receptor had different in-vivo:in-vitro ratios, and the ggTas2r-promiscuous ligand did not exhibit lower in-vivo:in-vitro ratios than ggTas2r-selective ligands. In-vivo thresholds were similar or up to two orders of magnitude higher than the in-vitro ones.
Linear relationship between H+-trapping reaction energy and defect generation: Insight into nitrogen-enhanced negative bias temperature instability (2003)

In this letter, we report a first-principles calculation which is well correlated to experiment on the role of nitrogen at Si/SiOxNy interface in negative bias temperature instability (NBTI). Our calculation shows that nitrogen’s lone pair electrons can trap dissociated hydrogen species more easily than oxygen. After trapping, a positive charge complex is formed and weakening of bond strength is observed at trapping site. Furthermore, as nitrogen concentration goes beyond 8 at. %, the neighboring effect from nitrogen starts to play a role in further degradation. The interfacial nitrogen dependence of the NBTI-induced defect generation is found to coincide with that of the H+-trapping reaction energy. Eventually, a linear correlation is found between the reaction energy and the defect generation. This provides an insight into nitrogen-enhanced NBTI.
Dendritic Cell-Targeted Phage Vectors for Breast Cancer Vaccine Development (2003)

Abstract : We hypothesize that one can use specific protein or peptide sequences to direct bacteriophage vectors to dendritic cells. We further propose that one can then use such re-targeted phage vectors to deliver potentially important antigens to dendritic cells, and that this may allow one to derive vectors capable of eliciting potent immune responses to breast cancer antigens such as her2. These hypotheses are being experimentally tested. During the period covered by this progress report, we have used phage display technology to identify peptide sequences which bind to cellular receptors expressed on dendritic cells, and we have conducted proof-of-concept studies to show that we can selectively target adenovirus vectors to dendritic cells using these peptide sequences. We have also shown that one can enhance intracellular internalization of T7 bacteriophage vectors using cell-binding peptides. We are now examining whether can use these same peptide sequences to deliver T7 and lambda phage vectors encoding a mammalian expression cassette, to primary dendritic cells. These experiments are expected to provide direct support for our hypothesis, that one can use phage vectors to express foreign genes in dendritic cells (including antigenic molecules, such as her2).
Influence of Handset Components into the Behavior of a Handset Antenna in a Slotted Ground Plane (2013)

ABSTRACT The influence of handset components needs to be analyzed in order to optimize the integration of the antenna into a handset device. Therefore, a multiband handset antenna combining a planar spiral‐shaped monopole and a slotted ground plane is used to study the influence of different components over the antenna performance. The antenna features a suitable behavior to operate in several mobile communication standards such as GSM850, GSM900, GSM1800, GSM1900, UMTS2100, LTE2100, LTE2300, WiFi, and Bluetooth. The effect of a display, a speaker, and a battery has been investigated and recommendation rules are proposed in order to facilitate the integration of those components over the slotted ground plane without degrading the multiband performance. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1770–1779, 2013
Calculation of the electronic spectra and excited-state distortions of W(CO)5(N-donor) from preresonance Raman intensities (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of the electronic spectra and excited-state distortions of W(CO)5(N-donor) from preresonance Raman intensitiesLee. Tutt and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 1986, 108, 19, 5830–5836Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/ja00279a028https://doi.org/10.1021/ja00279a028research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: On the Alkylation Behavior of 2‐(Phenylseleno) Nitriles. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cooper-pair insulator phase in superconducting amorphous Bi films induced by nanometer-scale thickness variations (2011)

Ultrathin films near the quantum insulator-superconductor transition (IST) can exhibit Cooper-pair transport in their insulating state. This Cooper-pair insulator (CPI) state is achieved in amorphous Bi films evaporated onto substrates with a topography varying on lengths slightly greater than the superconducting coherence length. We present evidence that this topography induces film thickness and corresponding superconducting coupling constant variations that promote Cooper-pair island formation. Analyses of many thickness-tuned ISTs show that weak links between superconducting islands dominate the transport. In particular, the IST occurs when the link resistance approaches the resistance quantum for pairs. These results support conjectures that the CPI is an inhomogeneous state of matter.
Alignment of short axis and long axis cine cardiac MR images (2006)

&lt;p&gt;Modern cardiac MRI exams usually contain cine acquisitions from three standardized, orthogonal views, ie. short axis (SA), long axis (LA) two-chamber and long axis four-chamber views. These images are acquired during different breath-holds introducing respiratory motion artefacts. Therefore, registration of SA and LA cine cardiac MR images is a preliminary, mandatory step for all applications using image information from different slices and views. We have developed two methods for the registration of SA images to LA images. Both methods improve the alignment of cardiac image data. Consequently, the result of a combined segmentation approach improves.&lt;/p&gt;
Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis (2022)

British Heart Foundation, UK National Institute for Health Research, and Oxford Martin School.
Interferon‐γ constrains cytokine production of group 2 innate lymphoid cells (2015)

Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epithelia, macrophages and natural killer T (NKT) cells in response to infection and allergen exposure, leading to epithelial injury. We examined gene expression in lung ILC2s and found that ILC2s expressed Ifngr1, the receptor for interferon-γ (IFN-γ). Interferon-γ severely inhibited IL-5 and IL-13 production by lung and kidney ILC2s. To evaluate the effects in vivo, we used α-galactosylceramide (α-GalCer) to induce NKT cells to produce IL-33 and IFN-γ. Intraperitoneal injection of α-GalCer in mice induced NKT cell activation resulting in IL-5 and IL-13 production by ILC2s. Administration of anti-IFN-γ together with α-GalCer significantly enhanced the production of IL-5 and IL-13 by ILC2s in lung and kidney. Conversely, cytokine production from ILC2s was markedly suppressed after injection of exogenous IL-33 in Il33(-/-) mice pre-treated with α-GalCer. Hence, IFN-γ induced or already present in tissues can impact downstream pleiotropic functions mediated by ILC2s, such as inflammation and tissue repair.
Hydrogen gas diffusion influences cavity pressure of encapsulated inertial sensors (2022)

MEMS inertial sensors are oscillatory electro-mechanical devices that detect relative motion in an inertial frame. Frictional losses in these systems, expressed as a quality factor Q, directly have bearing on their absolute measurement accuracy, and hence on the duration of an acceptably accurate response, for example during blind navigation. One of the sources of loss of quality factor is gas friction, which is reduced by operating such a device in an evacuated cavity. Because of the space constraints of many applications, inertial sensor packaging is kept slender and as close as possible to a device's functional parts. Through accelerated environmental tests, our measurements suggest that hydrogen gas molecules can diffuse out of the sensor cavity and change the quality factor. We propose a novel wafer-cutting methodology which allows to quantify diffusion paths through all micromechanical layers of a wafer, for the first time on wafer level, by facilitating different routes from the inner cavity to the ambient. We used the measurements of several hundred gyroscopes to validate a simulation model and protocol, so that cavity pressure changes over time can be numerically predicted. This is the first report on the systematic characterization of gas diffusion from micromachined cavities considering the influence of wafer dicing.
Supplementary Table S5 from Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma (2023)

&lt;p&gt;Table S5&lt;/p&gt;