gebhart/patrepeval huggingface dataset:
Assembled Camshaft with Sintered Cam Lobes: Torsional Fatigue Strength and Wear Performance (2000)

&lt;div class="htmlview paragraph"&gt;During the past five years the use of assembled camshafts in the North American automotive market has grown steadily. For valve-trains that operate with roller followers at relatively high contact stress, assembled camshafts are a cost-effective solution, as compared to camshafts machined from forged bar stock. Forged bearing steels, and, to a lesser extent, powder forged steels, have been the materials of choice for the manufacture of cam lobes for assembled camshafts. Sintered alloys offer an attractive alternative to forged steel because very accurate cam lobes can be manufactured via pressing and sintering. However, the use of sintered alloys has been limited by their relatively low rolling contact fatigue properties.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper presents the application of sintered lobes in mechanically assembled camshafts that operate in roller follower valve-trains at relatively high contact stress. Cam lobes were pressed and sintered to densities in the range 7.6-7.65 g/cm&lt;sup&gt;3&lt;/sup&gt; and case hardened to a macrohardness of 58-60 HRc. The lobes were assembled on a low alloy steel tube. An interference stress was generated between the tube and the components through mechanical expansion of the tube with a mandrel.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A key functional aspect of assembled camshafts is the strength of the assembly. Specifically, the torsional static and fatigue strength of the bond between the shaft and the cam lobe-or any other assembled component e.g. driving sprockets, journal bearings and cams for unitary Diesel injectors. Torsional static and fatigue tests show that with relatively lightweight construction (tube wall thickness in the range 2 - 3 mm) it is possible to achieve static torque strengths in the range 200-300 Nm and torsional fatigue endurance limits in the range 190-210 Nm. For heavy-duty applications, camshafts with tube wall thickness of 6 mm can increase the static strength to 1,500 Nm. The static and fatigue failure modes are different. Static failure results from displacement of the lobe relative to the tube. In contrast, under torsional fatigue, the failure is due to fatigue of the tube, with a crack initiating in areas of high stress concentration. Through proper camshaft design, the necessary combination of static and fatigue strength can be achieved.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The sintered alloys developed exhibit a rolling contact fatigue endurance limit that can exceed 2,500 MPa. Camshafts manufactured with these alloys have been validated in fired engine tests, including a 3.4 L V6 engine with a type 5 valve-train (push-rod with roller follower) that operates at a contact stress of approximately 2,000 MPa. Three 300-hour power tests and one 1,000-hour idle test were completed. The sintered cam lobes exhibited no pitting and the cam lobe wear was negligible.&lt;/div&gt;
Understanding the Oxygen Reduction Reaction Activity and Oxidative Stability of Pt Supported on Nb‐Doped TiO2 (2019)

Commercial fuel cell electrocatalyst degradation results from carbon electrocatalyst support oxidation at high operating potential transients. Guided by density functional theory (DFT) calculations, Nb-doped TiO<sub>2</sub> (NTO) was synthesized, which exhibits a unique combination of high surface area, high electrical conductivity, and high porosity. This catalyst retained 78 % of its initial electrochemically active surface area compared with 57.6 % retained by Pt/C following the DOE/FCCJ protocol for accelerated stability test. Strong metal-support interactions, which were predicted by DFT calculations and confirmed experimentally by X-ray photoelectron spectroscopy and kinetics measurements, resulted in 21 % higher oxygen reduction reaction mass activity (at 0.9 V vs. reversible hydrogen electrode) on Pt/NTO compared with commercial Pt/C. The ex situ activity and durability of Pt/NTO translated to a fuel cell. The rise in electrode ohmic resistance and non-electrode concentration overpotential indicate that improving the conductivity of NTO and optimizing the catalyst ink formulation are critical next steps in the development of Pt/NTO-catalyzed proton exchange membrane fuel cells.
Multi-modal graphene polymer interface characterization platform for vaporizable electronics (2015)

Characterization of physical and chemical properties of organic thin films such as polycarbonates is essential for their application-specific design. In this paper, we report a novel micromechanical resonant membrane platform with both graphene resistivity and mass-dependent frequency sensing to measure the thermal response, vaporization, and subsequent mass change of thin-film analytes deposited on top of the membrane. Graphene transferred on silicon nitride (Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> ) is below the analyte thin film, and the graphene resistance changes due to dangling bond interactions between the analyte film and graphene surface. At the same time, the resonance frequency of the analyte film/graphene/Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> composite membrane changes with variations in temperature, mechanical properties, mass and elasticity of the analyte film. This device provides a bi-modal characterization of the organic thin film, both in the electrical and mechanical domain, which allows one to identify and optimize the organic film formulation. As an example, we demonstrate differentiating formulations of a polymer blend to realize low degradation temperature, which is critical for vaporizable electronics enabling low-power transience.
Continuous Microfluidic Biosensing With Conjugated Paramagnetic Beads (2008)

A microfluidic biosensing assay has been designed and tested with streptavidin coated paramagnetic microbeads and fluorescently conjugated biotin (Biotin-FITC). The device is a three-inlet, three-outlet channel made by soft lithography of polydimethylsiloxane (PDMS). A novel magnetic actuation scheme is used to manipulate the beads within the channel. The device has proven capable of measuring the antigen concentration of a continuous sample stream. It is proposed that this technology could be applied as a real-time immunosensing assay.
Self maintenance of multiple views in data warehousing (1999)

Materialized views (MV) at the data warehouse (DW) can be kept up to date in response to changes in data sources without accessing data sources for additional information.
Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells (2003)

Fluid shear stress is a major factor involved in the control of gene expression in vascular endothelial cells. Sphingosine 1-phosphate has emerged as a multifaceted regulator of endothelial cell function and its high affinity S1P1 receptor is one among the many shear stress regulated genes. We recently identified the orphan G protein coupled receptors gpr3, gpr6 and gpr12 as additional S1P receptors. Here, we investigated their expression in various human endothelial and vascular smooth muscle cell lines via RT-PCR and western blot analysis. We next sought to determine the role of fluid shear stress in the regulation of expression of gpr3, gpr6 and gpr12 by using human umbilical vein endothelial cells (HUVECs). Laminar shear stress (12dyne/cm2) did not significantly increase gpr3, gpr6 and gpr12 mRNA after 1, 2, 4, 6, and 8 hrs of application of elevated pressure as determined by quantitative Taqman RT-PCR analysis. In contrast, gpr3 and gpr12 protein were increased after 12 hrs of shear stress by 95% and 40%, respectively. gpr6 mRNA and protein were absent in HUVECs as determined by Taqman and western blot techniques. Our results suggest that shear stress regulates gpr3 and gpr12 but not gpr6 expression and that regulation does not occur transcriptionally but posttranslationally. gpr3 and gpr12 may therefore add to the repertoire of S1P receptors, translating extracellular S1P effects into intracellular signals in human endothelial cells.
40-Gb/s Optical Packet Clock Recovery With Simultaneous Reshaping Using a Traveling-Wave Electroabsorption Modulator-Based Ring Oscillator (2004)

An injection-locking traveling-wave electroabsorption modulator-based ring oscillator is demonstrated to perform optical clock recovery and simultaneous reshaping of 40-Gb/s optical packets. The transient response analysis and experimental results show strong injection and short loop length reduce the locking time to within 0.3 μs. The recovered packet optical clock has 532-fs timing jitter.
External Optical Probe for Novel on-line Testing Method of Digital Circuits (2003)

International audience
Understanding large text corpora via sparse machine learning (2013)

Abstract Sparse machine learning has recently emerged as powerful tool to obtain models of high‐dimensional data with high degree of interpretability, at low computational cost. The approach has been successfully used in many areas, such as signal and image processing. This article posits that these methods can be extremely useful in the analysis of large collections of text documents, without requiring user expertise in machine learning. Our approach relies on three main ingredients: (i) multidocument text summarization; (ii) comparative summarization of two corpora, both using sparse regression or classification; (iii) sparse principal components and sparse graphical models for unsupervised analysis and visualization of large text corpora. We validate our methods using a corpus of Aviation Safety Reporting System (ASRS) reports and demonstrate that the methods can reveal causal and contributing factors in runway incursions. Furthermore, we show that the methods automatically discover four main tasks that pilots perform during flight, which can aid in further understanding the causal and contributing factors to runway incursions and other drivers for aviation safety incidents. We also provide a comparative study involving other commonly used datasets, and report on the competitiveness of sparse machine learning compared to state‐of‐the‐art methods such as latent Dirichlet allocation (LDA). © 2013 Wiley Periodicals, Inc. Statistical Analysis and Data Mining 6: 221–242, 2013
Interference Based Power Control Performance in LTE Uplink (2008)

In LTE uplink, the slow varying path gain and shadowing are compensated by the standardized open loop power control (OLPC). Further optimization of the system performance can be done via closed loop power control commands. In this contribution, it is shown that using such commands to control the interference caused by users to the system, it is possible to achieve a gain in the order of 20% on the average cell throughput while maintaining the same outage cell throughput compared to the performance of the OLPC. Furthermore, gain on both average and outage cell throughput can be achieved by tuning the parameters of the proposed scheme.
Impact of peer-to-peer applications on wide area network traffic: an experimental approach (2005)

To evaluate the impact of peer-to-peer applications on traffic in wide area IP networks, we analyze measurements from a high speed backbone link carrying TCP traffic towards several ADSL areas. The first observations are that the prevalent part of traffic is due to peer-to-peer applications (almost 80% of total traffic) and that the usage of network becomes symmetric in the sense that customers are not only clients but also servers. This latter point is observed by the significant proportion of long flows mainly composed of ACK segments. When analyzing the bit rate created by long flows, it turns out that those TCP connections due to peer-to-peer applications have a rather small bit rate and that there is no evidence for long range dependence. These facts are intimately related to the way peer-to-peer protocols are running.
A comprehensive genome‐scale reconstruction of Escherichia coli metabolism—2011 (2011)

The initial genome-scale reconstruction of the metabolic network of Escherichia coli K-12 MG1655 was assembled in 2000. It has been updated and periodically released since then based on new and curated genomic and biochemical knowledge. An update has now been built, named iJO1366, which accounts for 1366 genes, 2251 metabolic reactions, and 1136 unique metabolites. iJO1366 was (1) updated in part using a new experimental screen of 1075 gene knockout strains, illuminating cases where alternative pathways and isozymes are yet to be discovered, (2) compared with its predecessor and to experimental data sets to confirm that it continues to make accurate phenotypic predictions of growth on different substrates and for gene knockout strains, and (3) mapped to the genomes of all available sequenced E. coli strains, including pathogens, leading to the identification of hundreds of unannotated genes in these organisms. Like its predecessors, the iJO1366 reconstruction is expected to be widely deployed for studying the systems biology of E. coli and for metabolic engineering applications.
Photoimageable polymer waveguides for optoelectronic applications (2002)

The authors present in the paper the fabrication and characterization of spin-coatable, photoimageable polymer waveguides based on poly(phenylene). The precursors were converted into poly(phenylene) by curing at 300/spl deg/C for 6 hours or by UV exposure in the presence of a photoacid generator. Several bake temperature vs time cycles were investigated for determining optimum bake times and temperatures. Poly(phenylene) has several unique properties: good near-IR transmission, good thermal and environmental stability and excellent photopatterning capabilities among others that are desirable for optical waveguides. The authors present the near-IR spectrum of poly(phenylene) which shows that the poly(phenylene) has good optical properties (/spl sim/100% transmission) in the near-IR region. The polymer is highly resistant to thermal decomposition and oxidation and is stable against weight loss up to 450/spl deg/C in nitrogen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Resistance to reduction of a lead-based perovskite and its application to multilayer capacitor with copper electrode (1989)

Abstract Dielectric ceramics of lead-based perovskite represented (PbaCab{(Mg1/3Nb2/3)xTiy(Ni1/2W1/2)z}O2+a+b was fired in various oxygen pressure. The composition of A-site excess (a + b > 1) specimens fired in low oxygen pressure had high resistivity than the stoichiometry and the a-site deficient (a + b < = 1) one. It was found that the conduction type of these ceramics was changed p to n-type with decreasing of the oxygen pressure, and the specimens fired in not n-type region had high resistivity. Multilayer ceramic capacitor with copper electrode was prepared using the A-site excess composition and firing in controlled low oxygen atmosphere.
Microstrip-fed slot antennas with suppressed harmonics (2005)

In this paper, microstrip-fed slot antennas with suppressed harmonics are proposed. To obtain this operation, conductor lines connected with ground plane are inserted in slot antennas. To verify the validation of the proposed antennas, the equivalent circuit analysis is presented. Also, the miniaturization and bandwidth enhancement of the antenna for various applications are achieved and analyzed through parameter study. From the measured return losses, input impedances, and radiation patterns, it is shown that the proposed antennas offer excellent harmonic suppression characteristic in harmonic bandwidth including the second and third harmonic frequencies.
The Destination of Money (2021)

In February 2021, Marie Ekeland, one of the most influential figures in the French FinTech sector, set out the ambition for her new funding vehicle 2050 – designed to have a long-term positive impact on issues like equality and sustainability – in the following way: When you invest, you’re shaping the future. When you put your money here, you’re not just following the wind, you’re making it blow. So the real question is: ‘What is the world you want to live in?’ This question is very complex to answer because we’re living in a very complex world and there is no vision that is well articulated today.1 In the absence of an overarching and positive vision of how to build a better world collectively through formal democratic processes, and with the future appearing to promise little more than an endless series of world-ending threats to be managed in order to mitigate their most harmful effects, Ekeland struck a more optimistic note in the same article with a very simple but profound observation: ‘Money is actually very powerful but it has to have a destination … If finance is only reproducing the past, then we’re not going to find any solutions to the current new challenges that we have because people do not know how to solve them.’ The story that finance likes to tell about itself, at least since the entrepreneurial turn of the 1980s, is that it is at the cutting edge of innovation.
In situ photopolymerization and gelation of water-soluble monomers: a new approach for local administration of peptide drugs (1992)

Materials for use in controlled release of water sol. macromol. drugs, such as proteins and polysaccharides, were developed, i.e. (1) a material that would be phase compatible with the water sol. drug; (2) a material that would induce a reduced inflammatory reaction by comparison with conventional materials; and (3) a material that could be formed in situ by a rapid light-induced crosslinking. The requirement for in situ polymn. mandates that the precursor be applied either neat or as an aq. soln., and that the precursor not cause undue cytotoxicity. For this reason, water-sol. precursors were developed which upon exposure to light in the presence of a suitable photoinitiator would crosslink to form a hydrogel. Polymn. in situ has some conceptual advantages over the use of preformed objects, in that (1) a conformal coating can be applied to an irregularly shaped tissue, and (2) a large object can be delivered, as a liq., through a very small port and assembled in situ. [on SciFinder (R)]
New Decision Support Tool for Treatment Intensity Choice in Childhood Acute Lymphoblastic Leukemia (2009)

Acute lymphoblastic leukemia (ALL), the most common cancer in childhood, has its treatment modulated by the risk of relapse. An appropriate estimation of this risk is the most important factor for the definition of treatment strategy. In this paper, we build up a new decision support tool to improve treatment intensity choice in childhood ALL. Our procedure was applied to a significant cohort of Brazilian children with ALL, the majority of the cases treated in the last decade in the two main University Hospitals of Rio de Janeiro. Some intrinsically difficulties of this dataset introduce an assortment of challenges, among those the need of a proper selection of features, clinical and laboratorial data. We apply a mutual information-based methodology for this purpose and a Neural Network to estimate the risk. Among the relapsed patients, 98.2% would have been identified as high-risk by the proposed methodology. The proposed procedure showed significantly better results when compared to the BFM95, a widely used classification protocol.
ChemInform Abstract: Cobalt(II) Complex of a Novel Pentadentate Half‐Clathro Half‐Cyclidene Ligand Produced by a Base‐Catalyzed Ligand Rearrangement. (1987)

Abstract The low‐spin Co(II) complex (I) of an unsaturated macrocycle is synthesized by reaction of the protonated ligand with Co acetate in refluxing MeOH under basic conditions.
Donecopride, a Swiss army knife with potential against Alzheimer's disease (2019)

Donecopride acts like a Swiss army knife, exhibiting a range of sustainable symptomatic therapeutic effects and potential disease-modifying effects in models of AD. Clinical trials with this promising drug candidate will soon be undertaken to confirm its therapeutic potential in humans.
Ultralow impedance analysis and evaluation of power distribution network for decoupling capacitor embedded interposers of 3-D integrated LSI system (2012)

We evaluated low-impedance power distribution network (PDN) of decoupling capacitor embedded interposers for 3-D integrated LSI system. Measurements are carried out using the developed impedance analyzer system of a wide frequency range for evaluating ultralow impedance, and calculations are carried out using 2.5-D and 3-D finite element method (FEM) electromagnetic field simulator. We fabricated various types of capacitor mounted or capacitor embedded interposers test element group (TEG), such as surface-mounted and embedded chip capacitors, and thin film capacitors on silicon interposers using the same simple design to compare measurement results with calculation ones. As a result, the ultralow impedance evaluation system that has a high measurement dynamic range at the entire measurable frequency band can be realized. Furthermore, by using 2.5-D and 3-D FEM electromagnetic field simulator, it is expected that the accurate and wideband comparative verification of the PDN impedance analysis and evaluation can be realized.
Design and implementation of a soil moisture wireless sensor network (2015)

This paper presents the design of a shortest path tree based data collection wireless sensor network to sense soil moisture, soil temperature and relative humidity. Each node in the network follows a synchronized, periodic sleep - wake up schedule in order to maximize the lifetime of the network. The paper also demonstrates the implementation of a cluster based sensor network consisting of 10 nodes grouped as 3 clusters which collects and sends sensed data to a base station (here laptop) through a sink node. Data processing and presentation on the laptop is achieved using custom designed graphical user interface (GUI) in MATLAB. Nodes are kept approximately 8m apart covering an area of 400 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The implemented sensor network features using in house developed, low cost dual probe heat pulse (DPHP) soil moisture sensor, soil temperature sensor and energy efficient wireless transmission using clustering architecture for agricultural application. Field testing for 20% moisture level is demonstrated while feasibility of measuring the moisture levels from 0% to 40% is established from lab experiments.
Supplemental Figure 1-11 from CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion (2023)

&lt;p&gt;Supplemental figure 1-11 which include: (1) High resolution image of figure 1A. (2) Supplemental data for the relation between CCR5+ cells and breast cancer stem cells. (3) In vivo tumor formation of CCR5+ vs CCR5- cells. (4) In vivo tumor formation of CCR5 overexpression cells vs vector control cells. (5) Gene expression profile of CCR5+ vs CCR5- cells. (6) The effects of CCR5 on DNA damage repair in MDA-MB-231 cells. (7) A schematic representation of the DNA damage signaling pathways, with target genes enriched in CCR5+ cells. (8) The effects of CCR5 on DNA damage repair based on DNA damage repair reporter assays. (9) The functional synergy of cell killing between CCR5 inhibitors and Doxorubicin. (10) Single cell RNAseq of CCR5+ vs. CCR5- SUM-159 cells. (11) Enrichment of CCR5+ cells in doxorubicin resistant cells.&lt;/p&gt;