gebhart/patrepeval huggingface dataset:
Abstract 73: Lipid Mediators as Novel Biomarkers and Surrogate Indicators of Neurologic Recovery after Cardiac Arrest in a Hypothermic Swine Model (2006)

Background: Prognostic tools to predict neurologic outcome are essential so that relevant care can be given to patients awakening from coma, and futile intensive care be avoided in patients with severe hypoxic ischemic encephalopathy. There is a need for biomarkers as surrogate indicators of ischemic brain injury or recovery. We studied lipid mediators (Neuroprotectin D1, (NPD1), DHA, PGE-2, and PGD-2) that would reflect the status of anti-inflammatory signaling in endothelial cells and/or brain parenchyma. Methods: Swine who had return of spontaneous circulation (ROSC) after cardiac arrest, with CPR, and up to 3 shocks were randomized to receive 20 hours of hypothermia with Life Recovery Systems (LRS) Thermosuita,,¢ at 34A° C (n=6) or as normothermic controls (n = 8). Serial blood samples were obtained at intervals up to 48 hrs. Results: The time required to reach the target cooling temperature was 9.0 min. Normal neurologic function was regained in all 6 hypothermic animals but in only 1 of 8 normothe...
Pendeo-epitaxial growth and characterization of thin films of gallium nitride and related materials on SiC(0001) and Si(111) substrates (2001)

Monocrystalline GaN and Al{sub x}Ga{sub 1-x}N films have been grown via the pendeo-epitaxy (PE) technique with and without Si{sub 3}N{sub 4} masks on GaN/AlN/6H-SiC(0001) and GaN(0001)/AlN(0001)/3C-SiC(111)/Si(111) substrates using organometallic vapor phase deposition. Scanning and transmission electron microscopies were used to evaluate the external microstructures and the distribution of dislocations, respectively. The dislocation densities in the PE grown films were reduced at least five orders of magnitude relative to the initial GaN seed layers. Tilting to 0.2 in the portion of the coalesced GaN epilayers grown over the silicon nitride masks was observed via X-ray diffraction. Neither tilting nor low angle boundaries were observed within areas of coalescence in the material grown on substrates without the masks. (orig.)
Knowledge Engineering for Planning-Based Hypothesis Generation (2014)

In this paper, we address the knowledge engineering problems for hypothesis generation motivated by applications that require timely exploration of hypotheses under unreliable observations. We looked at two applications: malware detection and intensive care delivery. In intensive care, the goal is to generate plausible hypotheses about the condition of the patient from clinical observations and further refine these hypotheses to create a recovery plan for the patient. Similarly, preventing malware spread within a corporate network involves generating hypotheses from network traffic data and selecting preventive actions. To this end, building on the already established characterization and use of AI planning for similar problems, we propose use of planning for the hypothesis generation problem. However, to deal with uncertainty, incomplete model description and unreliable observations, we need to use a planner capable of generating multiple high-quality plans. To capture the model description we propose a language called LTS++ and a web-based tool that enables the specification of the LTS++ model and a set of observations. We also proposed a 9-step process that helps provide guidance to the domain expert in specifying the LTS++ model. The hypotheses are then generated by running a planner on the translated LTS++ model and the provided trace. The hypotheses can be visualized and shown to the analyst or can be further investigated automatically.
Phononic BandGap coupled Bulk Acoustic wave Resonators (2012)

This paper presents the design, a (equivalent circuit) model and the characterization of coupled Bulk Acoustic wave Resonators (BARs) using Phononic BandGaps (PBGs) as coupling elements. Bar-type BARs are represented as 1D acoustic transmission lines to describe all harmonic acoustic extensional-mode resonances, and, further, the lumped network representation of PBGs with purely reactive elements defining the equivalent of non-propagating 1D metamaterials is discussed. Measured transmission data, in good agreement with their simulated counterparts, establish the validity of the derived models that thus effectively depict the behaviours of BARs, PBGs and PBG coupled BARs. This work opens perspective for the design and realisation of left-handed acoustic TLs by implementing mixed acoustic plasma media of the type demonstrated in this paper.
Bendamustine and Rituximab for the Treatment of Chronic Lymphocytic Leukemia: The Moffitt Cancer Center Experience (2011)

Abstract Abstract 4620 Introduction: Although bendamustine is approved for the treatment of chronic lymphocytic leukemia (CLL), the combination of bendamustine and rituximab (BR) is currently under active investigation in the relapsed/refractory setting as well as for front-line use. Emerging data now suggests BR is acceptable for first-line use and indeed is listed in the NCCN Compendia as a first-line option. Herein, we report the results of a single-center retrospective review of BR use in first-, second- and third-line and beyond and its effects on response rate. Methods: We retrospectively reviewed 21 consecutive patients with CLL that received BR at the Moffitt Cancer Center (MCC) between July 2008 and November 2010. Bendamustine was dosed at 70 mg/m2 IV on Days 1 and 2 every 3–4 weeks; rituximab was dosed at 375 mg/m2 IV once with each cycle along with anti-microbial prophylaxis. Data collected included, but was not limited to age, gender, cytogenetic profile, number of previous therapies, Rai stage at time of treatment and response (based on 1996 NCI-WG definition). The primary objective was to assess response rates. The major secondary objective was to assess the effect of cytogenetics on response rates. All analyses were performed using descriptive statistics. Results: Twenty-one patients received treatment with BR; 7 patients received BR as first-line therapy, 7 received BR as second line therapy and the remaining 7 received BR as third-line therapy or beyond. The median age at time of treatment was 66; 12 of 21 patients were male (57%); All Rai Stages were represented, Stage 0 (n=1), Stage 1 (n=4), Stage 2 (n= 3), Stage 3 (n=5), Stage 4 (n=6). 38% of patients were positive for Del11q, 33% for Del13q, 9.5% for Del17p, and 9.5% for mutated IgVH. In previously untreated patients, 6/7 had a documented complete remission (CR) (71.4%) or partial (PR) (14.3%) response; one patient progressed (PD) on therapy. In second-line therapy, all patients had a documented CR (28.6%) or PR (71.4%). In patients treated with BR as 3rd or 4th line therapy, 3 patients had a CR, 2 patients had stable disease (SD), and 2 had PD. Of the 8 patients with Del11q, 37.5% achieved a CR, 4 had PR and 1 had PD. Of the 7 patients with Del13q, 4 achieved CR and 3 had a PR. Both patients with Del17p had PD. Of the 2 patients with mutated IgVH, one patient achieved a PR while the other had PD. Conclusion: Based on these results, the combination of bendamustine and rituximab in patients with CLL is efficacious and well tolerated in patients with both newly diagnosed and relapsed/refractory disease. Disclosures: Off Label Use: Bendamustine and rituximab for CLL. Ho:Genentech: Honoraria; Cephalon: Consultancy. Cultrera:Genentech: Speakers Bureau. Sotomayor:Genentech: Membership on an entity’s Board of Directors or advisory committees. Pinilla-Ibarz:Genentech: Speakers Bureau; Cephalon: Speakers Bureau.
The Search for New Fragrance Ingredients for Functional Perfumery (2005)

Functional perfumery is an integral part of the fragrance business. It demands that the ingredients chosen for compounding withstand the aggressive nature of some of the bases used for soaps, detergents, softeners, bleach, and personal-care products. The synthetic efforts in this area reported in this short personal account, presented in a talk at the RSC/SCI conference Flavours & Fragrances 2004 (Manchester), have resulted in the discovery of the two new proprietary molecules Fleuranil® (5/6) and Khusinil® (7), which fulfill the criteria of functional perfumery. The structure–odor relationships of several analogs of Fleuranil® and Khusinil® prepared in the course of these investigations are also presented.
Screening for Pancreatic Cancer Using Techniques to Detect Altered Gene Products (1998)

Although cancer of the pancreas accounts for only 2% of new cancer cases in the United States, it is the fifth leading cause of cancer death (1). This is true because many patients with pancreatic cancer are not diagnosed until late in the course of the disease, when the carcinoma has already metastasized or spread locally, and is no longer curable. Although 5-yr survival for all patients with cancer of the pancreas is 3% (2), 5-yr survival after successful pancreaticoduodenectomy (Whipple procedure) approaches 20% overall, and may be as high as 40% in patients with small tumors, negative lymph nodes, and negative surgical margins (3–4). Therefore, methods that can detect pancreatic cancers earlier, when they are still surgically resectable, will improve patient outcome.
Thermal management of high power transformer in different outdoor environment conditions (2004)

Power transformers play a vital role across the electrical grid network. This element of the grid network is commonly located in the outdoor environment. Unfortunately, there is no well defined environmental condition to be used as a design guide line. Therefore, this leads to a lack of defining the solar load effect, the worst maximum and minimum ambient temperature, the climbing ambient temperature variation per hour, the Pico and micro climate effects, the maximum altitude, the worst maximum and minimum relative humidity and the dew point temperature. In the present study, the thermal design of a single phase transformer is examined numerically. The environmental condition was selected based on 3 different cities in the northern hemisphere. These cities are Riyadh, Saudi Arabia, Colorado spring, USA and Ottawa, Canada. These cities represent the different environmental conditions which the power transformer can be subjected to it. The current investigation will determine the temperature variation across the windings, insulators and the core. These temperature variations can be eventually used to determine the potential thermal stresses which can lead to the major failure of the transformer. Finally, the authors will propose an environmental condition, which can be used in this type of product, which, in turns, can be used as a starting point for the thermal community to develop a special standard for outdoor high powered equipment.
Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library (2009)

In this study, we showed that hematein is a novel selective and cell permeable small molecule CK2 inhibitor. Hematein showed stronger growth inhibition effects to cancer cells when compared to normal cells. This compound may represent a promising class of CK2 inhibitors.
Experiment study of the decays of (112)Cs and (111)Xe (2012)

An experiment to search for the {alpha} decay of {sup 112}Cs has been performed at the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory. The {alpha} decay of {sup 112}Cs was not observed, thus setting the upper limit of the {alpha} branching ratio at 0.26%. The half-life of {sup 112}Cs was measured as 506 {+-} 55 {micro}s. In the same measurement the decay properties of its proton decay daughter {sup 111}Xe were also reinvestigated. The newly measured {alpha} branching ratio for {sup 111}Xe is 10.4 {+-} 1.9%. The experimental proton separation energies S{sub p} for odd-Z nuclei above {sup 100}Sn were compared to shell model calculations. The calculated proton separation energies for {sup 103}Sb and {sup 102}Sb point to half-lives of the order of 10 ps and 1 ns, respectively.
<p>Refractory Kawasaki disease: diagnostic and management challenges</p> (2019)

Kawasaki disease (KD), an acute, self-limiting, medium-sized arterial vasculitis, is now the most common cause of acquired heart disease in childhood in the developed world. In this review, we discuss the diagnosis of KD, predicting resistance to traditional therapy and treatment options in refractory or high-risk disease. We also highlight ongoing clinical trials and other potential avenues of research which may prove beneficial in managing children, especially those with resistant KD.
Signal Recovery on Incoherent Manifolds (2012)

Suppose that we observe noisy linear measurements of an unknown signal that can be modeled as the sum of two component signals, each of which arises from a nonlinear sub-manifold of a high dimensional ambient space. We introduce SPIN, a first order projected gradient method to recover the signal components. Despite the nonconvex nature of the recovery problem and the possibility of underdetermined measurements, SPIN provably recovers the signal components, provided that the signal manifolds are incoherent and that the measurement operator satisfies a certain restricted isometry property. SPIN significantly extends the scope of current recovery models and algorithms for low dimensional linear inverse problems and matches (or exceeds) the current state of the art in terms of performance.
Review on corrosion sensors for structural health monitoring of oil and natural gas infrastructure (2019)

Corrosion has been a great concern in the oil and natural gas industry. A variety of corrosion sensor technologies have been developed based on different sensing principles. Conventional corrosion sensors and emerging sensor technologies are critically reviewed in terms of sensing principles, sensor designs, advantages, and limitations. Conventional corrosion sensors encompass corrosion coupons, electrical resistance probes, electrochemical sensors, ultrasonic testing sensors, magnetic flux leakage sensors, electromagnetic sensors, and inline inspection tools. Emerging sensor technologies include optical fiber sensors (OFS) and passive wireless sensor technology such as surface acoustic wave (SAW) sensors. OFS have advantages of nondestructive monitoring, in-situ distributive measurements, long reach, small size, light weight, inherent immunity to electromagnetic interference, compatibility to optical fiber data communication systems, and improved safety in the presence of flammable gas/oil as compared to electrical based sensors. Passive SAW sensors have advantages of small size, cost efficiency, ease of fabrication, compatibility with wireless telemetry, and adaptability to many applications. Both emerging technologies are promising in corrosion monitoring in the oil and natural gas applications. The ability to monitor corrosion online before the structural integrity is compromised can have a significant impact on preventing catastrophic events resulting from corrosion. Distributed chemical sensing shows promising potential to detect early corrosion onset and monitor corrosive environments for corrosion mitigation management. Additionally, high durability and stability are required for corrosion sensors in extreme service conditions such as high temperature and high pressure during drilling, production, and refining.
Telomerase Reverse Transcriptase and Peroxisome Proliferator-Activated Receptor γ Co-Activator-1α Cooperate to Protect Cells from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence (2015)

Reduced telomere length with increasing age in dividing cells has been implicated in contributing to the pathologies of human aging, which include cardiovascular and metabolic disorders, through induction of cellular senescence. Telomere shortening results from the absence of telomerase, an enzyme required to maintain telomere length. Telomerase reverse transcriptase (TERT), the protein subunit of telomerase, is expressed only transiently in a subset of adult somatic cells, which include stem cells and smooth muscle cells. A recent report from Xiong and colleagues demonstrates a pivotal role for the transcription co-factor peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) in maintaining TERT expression and preventing vascular senescence and atherosclerosis in mice. Ablation of PGC-1α reduced TERT expression and increased DNA damage and reactive oxygen species (ROS), resulting in shortened telomeres and vascular senescence. In the ApoE(-/-) mouse model of atherosclerosis, forced expression of PGC-1α increased expression of TERT, extended telomeres, and reversed genomic DNA damage, vascular senescence, and the development of atherosclerotic plaques. Alpha lipoic acid (ALA) stimulated expression of PGC-1α and TERT and reversed DNA damage, vascular senescence, and atherosclerosis, similarly to ectopic expression of PGC-1α. ALA stimulated cyclic adenosine monophosphate (cAMP) signaling, which in turn activated the cAMP response element-binding protein (CREB), a co-factor for PGC-1α expression. The possibility that ALA might induce TERT to extend telomeres in human cells suggests that ALA may be useful in treating atherosclerosis and other aging-related diseases. However, further investigation is needed to identify whether ALA induces TERT in human cells, which cell types are susceptible, and whether such changes have clinical significance.
Key challenges to affordable see-through wearable displays: the missing link for mobile AR mass deployment (2013)

Low cost see-through technologies for wearable AR displays have been an elusive key element to enable the market for consumer oriented mobile AR. This paper will explore the various available technologies and the key challenges to develop a platform that will enable affordable wearable displays for the consumer and professional market.
Evaluation of threading dislocation densities in In- and N-face InN (2010)

The threading dislocation (TD) structure and density has been studied in In- and N-face InN films grown on GaN by plasma-assisted molecular beam epitaxy. The TD densities were determined by nondestructive x-ray diffraction rocking curve measurements in on-axis symmetric and off-axis skew symmetric geometries and calibrated by transmission electron microscopy measurements. TD densities were dominated by edge-type TDs with screw-component TDs accounting for less than 10% of the total TD density. A significant decrease in edge-type TD density was observed for In-face InN films grown at increasingly higher substrate temperatures. In-face InN films grown with excess In exhibited lower TD densities compared to films grown under N-rich conditions. The edge-type TD density of N-face InN films was independent of substrate temperature due to the higher allowable growth temperatures for N-face InN compared to In-face InN. TD densities in In-face InN also showed a strong dependence on film thickness. Films grown at a thickness of less than 1 μm had higher TD densities compared with films grown thicker than 1 μm. The lowest measured TD density for an In-face InN film was ∼1.5×1010/cm2 for 1 μm thick films.
Zero chirp broadband Z-cut LiNbO/sub 3/ optical modulator using polarization reversal and branch electrode (2004)

A novel single drive Z-cut Ti-diffused LiNbO/sub 3/ modulator with a small chirp parameter less than 0.02 was demonstrated using polarization reversal and branch electrode. The modulator showed preferable 10 Gb/s eye-opening and bias stability.
Learning a Discriminative Filter Bank within a CNN for Fine-grained Recognition (2016)

Compared to earlier multistage frameworks using CNN features, recent end-to-end deep approaches for fine-grained recognition essentially enhance the mid-level learning capability of CNNs. Previous approaches achieve this by introducing an auxiliary network to infuse localization information into the main classification network, or a sophisticated feature encoding method to capture higher order feature statistics. We show that mid-level representation learning can be enhanced within the CNN framework, by learning a bank of convolutional filters that capture class-specific discriminative patches without extra part or bounding box annotations. Such a filter bank is well structured, properly initialized and discriminatively learned through a novel asymmetric multi-stream architecture with convolutional filter supervision and a non-random layer initialization. Experimental results show that our approach achieves state-of-the-art on three publicly available fine-grained recognition datasets (CUB-200-2011, Stanford Cars and FGVC-Aircraft). Ablation studies and visualizations are provided to understand our approach.
Quenching effect of cerium oxide nanoparticles on singlet oxygen: validation of the potential for reaction with multiple reactive oxygen species (2023)

Here we studied cerium oxide nanoparticles (nanoceria) as an agent for the future treatment of oxidative damage by validating and evaluating its scavenging activity towards reactive oxygen species (ROS) <i>in vitro</i>. Nanoceria has been shown to mimic the activities of superoxide dismutase and catalase, degrading superoxide (O<sub>2</sub><sup>•-</sup>) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). We examined the antioxidative activity of nanoceria, focusing on its ability to quench singlet oxygen (<sup>1</sup>O<sub>2</sub>) in an aqueous solution. Electron paramagnetic resonance (EPR) was used to determine the rates of second-order reactions between nanoceria and three ROS (<sup>1</sup>O<sub>2</sub>, O<sub>2</sub><sup>•-</sup>, and H<sub>2</sub>O<sub>2</sub>) in aqueous solution, and its antioxidative abilities were demonstrated. Nanoceria shows a wide range of ultraviolet-light absorption bands and thus <sup>1</sup>O<sub>2</sub> was produced directly in a nanoceria suspension using high-frequency ultrasound. The quenching or scavenging abilities of nanoceria for <sup>1</sup>O<sub>2</sub> and hypoxanthine-xanthine oxidase reaction-derived O<sub>2</sub><sup>•-</sup> were examined by EPR spin-trapping methods, and the consumption of H<sub>2</sub>O<sub>2</sub> was estimated by the EPR oximetry method. Our results indicated that nanoceria interact not only with two previously reported ROS but also with <sup>1</sup>O<sub>2</sub>. Nanoceria were shown to degrade O<sub>2</sub><sup>•-</sup> and H<sub>2</sub>O<sub>2</sub>, and their ability to quench <sup>1</sup>O<sub>2</sub> may be one mechanism by which they protect against oxidative damage such as inflammation.
Antenne filaire tridimensionnelle très compacte pour applications RFID UH (2019)

International audience
Epitaxial deposition of silver ultra-fine nano-clusters on defect-free surfaces of HOPG-derived few-layer graphene in a UHV multi-chamber by in situ STM, ex situ XPS, and ab initio calculations (2012)

The growth of three-dimensional ultra-fine spherical nano-particles of silver on few layers of graphene derived from highly oriented pyrolytic graphite in ultra-high vacuum were characterized using in situ scanning tunneling microscopy (STM) in conjunction with X-ray photoelectron spectroscopy. The energetics of the Ag clusters was determined by DFT simulations. The Ag clusters appeared spherical with size distribution averaging approximately 2 nm in diameter. STM revealed the preferred site for the position of the Ag atom in the C-benzene ring of graphene. Of the three sites, the C-C bridge, the C-hexagon hollow, and the direct top of the C atom, Ag prefers to stay on top of the C atom, contrary to expectation of the hexagon-close packing. Ab initio calculations confirm the lowest potential energy between Ag and the graphene structure to be at the exact site determined from STM imaging.