gebhart/patrepeval huggingface dataset:
A clinical trial to validate event‐related potential markers of Alzheimer's disease in outpatient settings (2015)

Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.
The Mechanism of Respiratory Failure in Paraneoplastic Pemphigus (1999)

Paraneoplastic pemphigus1 is an autoimmune disease that accompanies an overt or occult neoplasm and causes blisters. It is characterized by the presence of IgG autoantibodies that react against desmosomal and hemidesmosomal plakin proteins,2–5 desmosomal transmembrane proteins (desmogleins),6 and an unidentified 170-kd antigen. Blistering of stratified squamous epithelium results from acantholysis, the loss of cell–cell adhesion, induced by pathogenic antibodies against the desmogleins.6 The most commonly associated neoplasms are, in decreasing order of frequency, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Castleman's disease, thymoma, retroperitoneal sarcomas, and Waldenstrom's macroglobulinemia. Progressive respiratory failure with clinical features of bronchiolitis obliterans is frequently the cause . . .
P2‐152: Pattern of beta‐amyloid production by mouse embryonic fibroblasts overexpressing psen1 with I143T mutation (2012)

Amyloid-β peptide (Aβ) is produced by the sequential cleavage of amyloid-β precursor protein (βAPP) by β -secretase and γ-secretase complex. Presenilins (PS1 and PS2) have been demonstrated to be the catalytic core of the γ-secretase complex. Most cases of early onset familial Alzheimer disease (EOFAD) have been reportedly caused by m utations in the presenilin genes (PSEN1 and PSEN2). Recently, both Aβ42 and Aβ43 were reported to be present in plaque cores in the brain of patients with PSEN1 I143T mutation, which is one of the earliest onset causative genes of EOFAD (average age of onset is 34.0). Furthermore, Aβ43 is reported to be amyloido g enic and pathogenic in PSEN1 R278I FAD. Wild-type and I143T mutant PSEN1 were subcloned into the retroviral vector pMXs-Puro, and these constructs were transfected to Platinum-E cells to package and produce retroviruses carrying either of these genes respectively. Next, PSEN1 and PSEN2 double knock out mouse embryonic fibroblasts (PSDKO/MEFs) overexpressing APP with Swedish mutation (SweAPP) were infected with retroviruses to transduce each PSEN1 gene for creating cell lines stably expressing each wild-type or I143T PS1. For measuring Aβ production by each cell line, 8×105 cells were plated into 6-well plates, and after 24-hour incubation, quantitative changes in Aβ40, Aβ42, and Aβ43 levels in the cell culture medium were measured using ELISA. The ratio of Aβ42 to Aβ40 is possibly the most important factor in determining the age at onset of EOFAD I143T, despite the fact that both Aβ42 and Aβ43 proteins are deposited in the brains of I143T patients.
Elastomers and Other Organic Composites (1990)

The objective of this program was to bring together five investigators whose expertise was in the area of polymer synthesis, characterization, rheology and processing, solid state morphology and mechanical behavior and surface science. This abstract will describe some highlights of research findings and potential applications. In addition, in an appendix we have included statistics on publications, preprints and theses.
Supp Table 1, Supp Table 2 from Involvement of Epigenetics and EMT-Related miRNA in Arsenic-Induced Neoplastic Transformation and Their Potential Clinical Use (2023)

&lt;p&gt;Supp Table 1, Supp Table 2. Supp Table 1: A.QMSP probe and primers, B.RT-PCR assay. Supplemental Table 2: The summary of notch methylation array findings&lt;/p&gt;
Models of the .beta. Protein C-Terminus: Differences in Amyloid Structure May Lead to Segregation of "Long" and "Short" Fibrils (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModels of the .beta. Protein C-Terminus: Differences in Amyloid Structure May Lead to Segregation of "Long" and "Short" FibrilsJoseph T. Jarrett, Philip R. Costa, Robert G. Griffin, and Peter T. Lansbury Jr.Cite this: J. Am. Chem. Soc. 1994, 116, 21, 9741–9742Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00100a046https://doi.org/10.1021/ja00100a046research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Synthesis of a Bipolar Phosphatidylethanolamine: A Model Compound for a Membrane‐Spanning Probe. (1987)

Abstract The mercaptododecanoic acid (Ib), obtained from the bromide (Ia) via the xanthogenate, reacts with benzaldehyde (II) to form the dithioacetal (III).
Effect of HPV on Treatment Outcome and Survival in Oropharyngeal Carcinoma - a Subgroup Analysis of the Randomized DAHANCA 5&7 Trials (2008)

Objectives: To demonstrate the correlation between p16 overexpression and HPV in oropharyngeal carcinoma and to evaluate the prognostic impact of p16 status in a prospectively analyzed cohort of Danish oropharyngeal cancer patients.Materials and Methods: 32 tonsillar carcinomas were arranged in a Tissue Micro Array and evaluated by IHC for p16 overexpression. HPV-16 DNA detection was done by in situ hybridization. Between 1986 and 1999 The Danish Head and Neck Cancer group conducted the DAHANCA 5&7 randomized trials. In the present study 335 pre-treatment oropharyngeal tumour blocks from patients enrolled in these trials were evaluated by IHC for p16 status. Results: 20 of 32 (62.5%) tonsillar carcinomas were HPV-16 positive and 19 of these were p16 positive (sensitivity: 0.95). 12 tumours were HPV-16 negative and 10 of these were p16 negative (specificity: 0.83). The two markers matched in 29 of 32 (90%) of the tumours.In total 135 of 335 (40%) oropharyngeal tumours were p16 positive.In univariate analysis, loco-regional tumour control was significantly improved for p16 positive tumours with 5-year actuarial values of 67% versus 36%, p < 0.0001. A similar beneficial outcome for p16 positive tumours was observed for cancer specific survival (69% versus 35%, p < 0.0001) and overall survival (54% versus 18%, p < 0.0001).In multivariate analysis p16 overexpression remained a very strong independent prognostic factor for loco-regional tumour control [OR: 0.35 (95% C.I. 0.24-0.51)], cancer specific death [OR: 0.28 (0.18-0.42)] and overall death [OR: 0.33 (0.24- 0.46)] respectively. p16 was an even stronger prognostic factor related to these outcomes than T-stage and Nodal-status.Conclusions: p16 overexpression proved to be the strongest independent prognostic factor related to survival and loco-regional tumour control in our study and so we conclude that HPV infection is significantly correlated to improved prognosis and response to radiotherapy in oropharyngeal cancer patients.
Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy. (2000)

Proton MRS detectability of alpha-Glx is increased in moderate and severe HIE and correlates with the Sarnat stage of HIE.
PCR Cloning of Neural Gene Products (1999)

Of the many proteins that are known to be involved in neuronal signaling, one family of gene products, collectively referred to as the G protein-coupled receptors (GPCRs), has received considerable attention. Within the transmembrane domains of GPCRs are clusters of amino acids that tend to be conserved among receptors that bind related ligands. Polymerase chain reaction (PCR)-based approaches to cloning novel GPCRs typically begin with the identification of these well-conserved amino acid motifs, which are then back-translated into degenerate oligonucleotide primers. These pools of degenerate oligonucleotides are the most important variables in PCR cloning of GPCRs. Although GPCRs are used as the focus of this unit, the strategies and techniques described are applicable to the cloning of a wide variety of neuronal gene products. In the first procedure in this unit, either total or poly(A)(+) purified RNA is reverse transcribed into first-strand cDNA. In subsequent steps the cDNA product serves as the template for synthesis and amplification of target receptor sequences by PCR primed with degenerate oligodeoxynucleotides. The product is ready to be cloned and screened as described. Guidelines for database searching are provided to help identify the cloned gene from the known sequence. Typically, only a portion of the receptor coding region is cloned by the above approach. Rapid amplification of cDNA ends (RACE) or anchored PCR is described in this unit and is used to obtain a full-length cDNA amenable for expression studies.
Online Model-based Diagnosis for Multiple, Intermittent and Interaction Faults (2009)

This paper extends model-Based diagnosis (MBD) (Reiter, 1987; de Kleer and Williams, 1987) to systems which convert, move and process materials or objects. Examples of such systems are printers, refineries, manufacturing lines and food processing plants. Such plants present two challenges to model-based diagnosis: (1) the plant may process with very high speed while handling multiple objects in parallel such that retaining full details of behavior of all past objects is impractical, and (2) complex multi-way interactions can occur among components operating on the same object. We address the first challenge by synopsizing past behavior and the current knowledge in a data structure of linear size in the number of components in the system. The second challenge is addressed by introducing the notion of interaction fault. An interaction fault is present if a set of components operating on the same object, damage the object even though each component alone produces non noticeable damage. Introducing interaction faults is much simpler than introducing fine-grained models of component-object interactions. We demonstrate the approach on a highly redundant printer
Multi-agent Attention Actor-Critic Algorithm for Load Balancing in Cellular Networks (2023)

In cellular networks, User Equipment (UE) handoff from one Base Station (BS) to another, giving rise to the load balancing problem among the BSs. To address this problem, BSs can work collaboratively to deliver a smooth migration (or handoff) and satisfy the UEs' service requirements. This paper formulates the load balancing problem as a Markov game and proposes a Robust Multi-agent Attention Actor-Critic (Robust-MA3C) algorithm that can facilitate collaboration among the BSs (i.e., agents). In particular, to solve the Markov game and find a Nash equilibrium policy, we embrace the idea of adopting a nature agent to model the system uncertainty. Moreover, we utilize the self-attention mechanism, which encourages high-performance BSs to assist low-performance BSs. In addition, we consider two types of schemes, which can facilitate load balancing for both active UEs and idle UEs. We carry out extensive evaluations by simulations, and simulation results illustrate that, compared to the state-of-the-art MARL methods, Robust-\ours~scheme can improve the overall performance by up to 45%.
HIGH DYNAMIC RANGE PASSIVE OPTICAL LIMITERS (1993)

We present results of optical limiting experiments designed to study optical geometries for increasing the dynamic range over which limiters function without incurring optical damage. Specifically, we investigate a tandem geometry with two passive nonlinear elements, one placed in the focal plane of a lens and the second placed “upstream” of the focal position to protect the material at focus from damage. To provide a proof-of-principle demonstration of this geometry, simple limiters consisting of combinations of reverse saturable absorber dyes and a carbon black suspension in thin cells were tested. Our results show that a substantial increase in device performance can be achieved by use of a tandem limiter geometry. Simple modelling predicts that the dynamic range of a separate-element tandem limiter is given by the product of the dynamic ranges of the individual component limiting elements, in agreement with our experimental results.
Cross-Linking Disulfonated Poly(arylene ether sulfone) Telechelic Oligomers. 1. Synthesis, Characterization, and Membrane Preparation (2014)

meta-Aminophenol was used during nucleophilic step copolymerization to end-cap partially disulfonated bisphenol A based random copolymers with controlled oligomeric molecular weights. The amine end groups were thermally reacted with a tetrafunctional epoxy reagent to produce networks. Very high gel fractions, up to 99%, and ductile film formation were achieved. The oligomer was further functionalized with acryloyl chloride, phenylethynyl phthalic anhydride, and maleic anhydride to obtain several novel free radically cross-linkable oligomers. The structure and molecular weights (Mn) were established with 1H NMR spectroscopy of the oligomers and end groups. TGA analysis demonstrated the high thermal stability of these oligomers; DSC investigations showed that the oligomers had curing exotherms from 140 to 330 °C and that residual casting solvent during cross-linking was necessary to avoid vitrification during membrane formation. In addition to the thermally cross-linkable systems, photocross-linking was demonstrated with the telechelic acrylamide functionalized oligomers. Two compositions were identified as potential candidates for further development. Cross-linking disulfonated poly(arylene ether sulfone) copolymers limits the high water sorption and swelling of these hydrophilic materials, which enhances several properties for membrane applications. Initial transport results indicate that cross-linking greatly reduces salt permeability while modestly decreasing water permeability, resulting in improved water/NaCl selectivity.
Correction: KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions, Vol 35 (6) 2005, DOI 10.1002/eji.200425932 (2005)

Unfortunately, in this article, the legend to Figure 3 was incomplete. The correct legend is as follows: Fig. 3. KARAP/DAP12-associated myeloid receptors. KARAP/DAP12-dependent receptors expressed in human and mouse myeloid cells are represented with their corresponding expression pattern. Unless indicated (m, mouse or h, human), receptor-ligand pairs are conserved in both humans and mice. The Figure indicates a non-covalent association between TREM-4 and DAP12. However, the prediction of the TREM-4 protein sequence indicates the absence of a positively charged amino acid in the transmembrane domain (accession number AF427620), consistent with a lack of interaction between TREM-4 and DAP12 (M. Colonna and L.L. Lanier, personal communication).
Energy-Based Pharmacophore and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) Modeling Combined with Virtual Screening To Identify Novel Small-Molecule Inhibitors of Silent Mating-Type Information Regulation 2 Homologue 1 (SIRT1) (2015)

Silent mating-type information regulation 2 homologue 1 (SIRT1), being the homologous enzyme of silent information regulator-2 gene in yeast, has multifaceted functions. It deacetylates a wide range of histone and nonhistone proteins; hence, it has good therapeutic importance. SIRT1 was believed to be overexpressed in many cancers (prostate, colon) and inflammatory disorders (rheumatoid arthritis). Hence, designing inhibitors against SIRT1 could be considered valuable. Both structure-based and ligand-based drug design strategies were employed to design novel inhibitors utilizing high-throughput virtual screening of chemical databases. An energy-based pharmacophore was generated using the crystal structure of SIRT1 bound with a small molecule inhibitor and compared with a ligand-based pharmacophore model that showed four similar features. A three-dimensional quantitative structure-activity relationship (3D-QSAR) model was developed and validated to be employed in the virtual screening protocol. Among the designed compounds, Lead 17 emerged as a promising SIRT1 inhibitor with IC50 of 4.34 μM and, at nanomolar concentration (360 nM), attenuated the proliferation of prostate cancer cells (LnCAP). In addition, Lead 17 significantly reduced production of reactive oxygen species, thereby reducing pro inflammatory cytokines such as IL6 and TNF-α. Furthermore, the anti-inflammatory potential of the compound was ascertained using an animal paw inflammation model induced by carrageenan. Thus, the identified SIRT1 inhibitors could be considered as potent leads to treat both cancer and inflammation.
Evaluating query languages and systems for high-energy physics data (2021)

In the domain of high-energy physics (HEP), query languages in general and SQL in particular have found limited acceptance. This is surprising since HEP data analysis matches the SQL model well: the data is fully structured and queried using mostly standard operators. To gain insights on why this is the case, we perform a comprehensive analysis of six diverse, general-purpose data processing platforms using an HEP benchmark. The result of the evaluation is an interesting and rather complex picture of existing solutions: Their query languages vary greatly in how natural and concise HEP query patterns can be expressed. Furthermore, most of them are also between one and two orders of magnitude slower than the domain-specific system used by particle physicists today. These observations suggest that, while database systems and their query languages are in principle viable tools for HEP, significant work remains to make them relevant to HEP researchers.
Embedded Multidie Interconnect Bridge—A Localized, High-Density Multichip Packaging Interconnect (2019)

This article provides an overview of the embedded multidie interconnect bridge (EMIB) multichip packaging (MCP) technology. EMIB is a unique packaging paradigm that provides very high-density interconnects (currently in the range of 500-1000 I/O/mm) localized in between two devices, thus enabling high-bandwidth (BW) on-package links while leaving the rest of the package structures and designs unaffected. The construction of the silicon bridge and the package to allow high BW electrical signaling between two dies is discussed in detail. Examples of the EMIB implementations for the links between the field-programmable gate array (FPGA) logic and high bandwidth memory generation 2 (HBM2) memory stacks, graphics die and HBM2 memory stacks, FPGA logic die, and high-performance transceiver die are described. EMIB packaging is compared with similar high-density interconnect technologies such as silicon interposer with through-silicon vias (TSVs) and other fan-outbased package technologies. Design optimization strategies for power delivery and I/O routing in the presence of an embedded bridge are highlighted.
Improving Energy Saving in Time-Division Multiplexing Passive Optical Networks (2012)

This article proposes a time-division multiplexing passive optical network (TDM-PON) architecture in which optical network units (ONUs) enter active mode only when the optical line terminal has traffic to deliver. The authors use a hybrid ONU (H-ONU) equipped with a low-cost, low-energy IEEE 802.15.4 module. This module notifies H-ONUs when they should move from sleep to active mode to receive downstream traffic. The authors show that the proposed solution leads to a significant energy saving while satisfying PON delay requirements.
Muon reconstruction performance of the ATLAS detector in proton–proton collision data at $$\sqrt{s}$$ s =13 TeV (2016)

This article documents the performance of the ATLAS muon identification and reconstruction using the LHC dataset recorded at [Formula: see text] TeV in 2015. Using a large sample of [Formula: see text] and [Formula: see text] decays from 3.2 fb[Formula: see text] of <i>pp</i> collision data, measurements of the reconstruction efficiency, as well as of the momentum scale and resolution, are presented and compared to Monte Carlo simulations. The reconstruction efficiency is measured to be close to [Formula: see text] over most of the covered phase space ([Formula: see text] and [Formula: see text] GeV). The isolation efficiency varies between 93 and [Formula: see text] depending on the selection applied and on the momentum of the muon. Both efficiencies are well reproduced in simulation. In the central region of the detector, the momentum resolution is measured to be [Formula: see text] ([Formula: see text]) for muons from [Formula: see text] ([Formula: see text]) decays, and the momentum scale is known with an uncertainty of [Formula: see text]. In the region [Formula: see text], the [Formula: see text] resolution for muons from [Formula: see text] decays is [Formula: see text] while the precision of the momentum scale for low-[Formula: see text] muons from [Formula: see text] decays is about [Formula: see text].
Supplementary Figure 2 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment (2023)

&lt;p&gt;PDF file - 241K&lt;/p&gt;
Effect of absorption on nonlinear propagation of short ultrasound pulses generated by rectangular transducers (2002)

A numerical solution of the KZK-type parabolic nonlinear evolution equation is presented for finite-amplitude sound beams radiated by rectangular sources. The initial acoustic waveform is a short tone burst, similar to those used in diagnostic ultrasound. The generation of higher harmonic components and their spatial structure are investigated for media similar to tissue with various frequency dependent absorption properties. Nonlinear propagation in a thermoviscous fluid with a quadratic frequency law of absorption is compared to that in tissue with a nearly linear frequency law of absorption. The algorithm is based on that originally developed by Lee and Hamilton [J. Acoust. Soc. Am. 97, 906–917 (1995)] to model circular sources. The algorithm is generalized for two-dimensional sources without axial symmetry. The diffraction integral is adapted in the time–domain for two dimensions with the implicit backward finite difference (IBFD) scheme in the nearfield and with the alternate direction implicit (ADI) method at longer distances. Arbitrary frequency dependence of absorption is included in this model and solved in the frequency–domain using the FFT technique. The results of simulation may be used to better understand the nonlinear beam structure for tissue harmonic imaging in modern medical diagnostic scanners. [Work supported by CRDF and RFBR.]