gebhart/patrepeval huggingface dataset:
STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors (2020)

Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in head and neck squamous cell carcinoma (HNSCC). A decoy oligonucleotide targeting STAT3 offers a promising anti-tumor strategy, but achieving targeted tumor delivery of the decoy with systemic administration poses a significant challenge. We previously showed the potential for STAT3 decoy-loaded microbubbles, in conjunction with ultrasound targeted microbubble cavitation (UTMC), to decrease tumor growth in murine squamous cell carcinoma. As a next step towards clinical translation, we sought to determine the anti-tumor efficacy of our STAT3 decoy delivery platform against human HNSCC and the effect of higher STAT3 decoy microbubble loading on tumor cell inhibition. STAT3 decoy was loaded on cationic lipid microbubbles (STAT3-MB) or loaded on liposome-conjugated lipid microbubbles to form STAT3-loaded liposome-microbubble complexes (STAT3-LPX). UTMC treatment efficacy with these two formulations was evaluated in vitro using viability and apoptosis assays in CAL33 (human HNSCC) cells. Anti-cancer efficacy in vivo was performed in a CAL33 tumor murine xenograft model. UTMC with STAT3-MB caused significantly lower CAL33 cell viability compared to UTMC with STAT3-LPX (56.8±8.4% vs 84.5±8.8%, respectively, p<0.05). In vivo, UTMC with STAT3-MB had strong anti-tumor effects, with significantly less tumor burden and greater survival compared to that of UTMC with microbubbles loaded with a mutant control decoy and untreated control groups (p<0.05). UTMC with STAT3 decoy-loaded microbubbles significantly decreases human HNSSC tumor progression. These data set the stage for clinical translation of our microbubble platform as an imaged-guided, targeted delivery strategy for STAT3 decoy, or other nucleotide-based therapeutics, in human cancer treatment.
Structure of a tetraphenyldiphosphine monoxide complex with two diphenylamine molecules (1990)

(C 6 H 5 ) 2 PP(O)(C 6 H 5 ) 2 •2(C 6 H 5 ) 2 NH cristallise dans P2 1 /n avec a=10,587, b=18,485 et c=10,026 A, β=90,59 o , Z=2; affinement jusqu'a R=0,042. La structure est desordonnee autour d'un cente d'inversion (au centre de la liaison P-P); la position de l'atome O n'est donc qu'a «demi-occupee» et egalement desordonnee sur les sites adjacents aux atomes P. La molecule diphenylamine unique prend part a une liaison hydrogene N-H...O de 2,690 A. Tandis que la distance P-P de 2,228 A est normale, la double liaison P=O est remarquablement courte (1,345 A)
Characterization of Inverse Temperature Dependence in logic circuits (2012)

As the supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> ) approaches the device threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ), the elevated temperature results in increased device current. This phenomenon is generally known as Inverse Temperature Dependence (ITD). In this paper, we propose a test structure with a built-in poly-resistor-based heater to characterize ITD in digital circuits. Our measurements from a 130nm test-chip show that the Zero-Temperature-Coefficient (ZTC) point varies by circuit type, and further fluctuates due to process variation. A more accurate ITD-sensitive thermal sensor is thus needed for better temperature tracking.
Allylic hydrocarbon polymers complexed with Fe(II)(salen) as a ultrahigh oxygen-scavenging and active packaging film (2020)

Abstract Macromolecular metal complexes provide a molecular-based synergy function of organic polymers and combined metal complexes. A new category of macromolecular complexes includes catalytically active metal complexes immobilized by organic polymers containing reactive substrate moieties in their repeating units. Here, we describe the extremely efficient oxidation of allylic hydrocarbon polymers with the attached iron complex catalyst, as well as the efficient oxygen-consumption or oxygen-scavenging function of the matrix polymer film. The less toxic N , N ´-di(salicylaldehyde)ethylenediiminatoiron(II) complex was combined with or fixed onto a series of allylic hydrocarbon polymers as both the oxidative substrate and the film matrix, i.e. poly(1,2-butadiene), polynorbornene, poly(5-vinyl-2-norbornene), poly(2,5-norboenadiene), poly(dicyclopentadiene), and poly(5-ethylidene-2-norbornene). Ultra-high oxygen-scavenging capacity up to 300 mL (oxygen gas at STP)/g(film) was achieved, based on the oxidative consumption of the allylic bond (particularly of poly(5-ethylidene-2-norbornene)), which was more than three times that of the previously reported highest oxygen-scavenging polymers. These oxygen-scavenging films are based on the high reactivity of polymer-metal complexes that provides an innovative development in the area of active packaging polymer films that facilitate cost-effective performance, safety, and sustainability.
The fungicide chloraniformethan and the herbicide dichlofopmethyl affect calmodulin‐dependent cyclic nucleotide phosphodiesterase from bovine brain (1983)

Calmodulin‐stimulated phosphodiesterase from bovine brain is inhibited by the fungicide chloraniformethan; the activity in the absence of calmodulin is not affected. The herbicide dichlofopmethyl enhances the basal activity and inhibits the calmodulin stimulation.
A TGF‐β‐induced gene, βig‐h3, is crucial for the apoptotic disappearance of the medial edge epithelium in palate fusion (2009)

TGF-beta3, TbetaR-I, and TGF-beta-activated Smad2 has been suggested to be a series of signaling molecules for secondary palate fusion. In this article, we show that a gene induced by TGF-beta, betaig-h3, is coincidentally expressed with TGF-beta3 in medial edge epithelial (MEE) cells undergoing apoptosis during normal palatal fusion. betaig-h3 was also highly expressed in the areas of post-weaning mammary gland cells and developing phalangeal joints in which TGF-beta3 or BMP-4-induced apoptosis occurs, respectively. Blocking of betaig-h3 expression in E12.5 embryos with antisense oligodeoxynucleotides (ODN) resulted in cleft of the secondary palate in 84% of the treated mice that were born. Moreover, the antisense ODN treatment resulted in a failure of apoptosis in the MEE between palatal shelves in physical contact in organ culture. We conclude that betaig-h3 expression in the MEE is stimulated by TGF-beta3, causes cell death, and consequently results in complete fusion of the apposed palatal shelves.
Commensurate Registry and Chemisorption at a Hetero-organic Interface (2012)

We present evidence for a partly chemisorptive bonding between single monolayers of copper-II-phthalocyanine (CuPc) and 3,4,9,10-perylene-tetracarboxylic-dianhydride (PTCDA) that are stacked on Ag(111). A commensurate registry between the two molecular layers and the substrate, i.e., a common crystallographic lattice for CuPc and PTCDA films as well as for the Ag(111) surface, indicates that the growth of the upper layer is dominated by the structure of the lower. Photoemission spectroscopy clearly reveals a gradual filling of the lowest unoccupied molecular orbital of PTCDA due to CuPc adsorption, which proves the chemisorptive character.
Prostate Cancer, Version 1.2016 (2016)

The NCCN Guidelines for Prostate Cancer address staging and risk assessment after an initial diagnosis of prostate cancer and management options for localized, regional, and metastatic disease. Recommendations for disease monitoring, treatment of recurrent disease, and systemic therapy for metastatic castration-recurrent prostate cancer also are included. This article summarizes the NCCN Prostate Cancer Panel's most significant discussions for the 2016 update of the guidelines, which include refinement of risk stratification methods and new options for the treatment of men with high-risk and very-high-risk disease and progressive castration-naïve disease.
Cautionary Note on the Use of Caenorhabditis Elegans to Study Muscle Phenotypes Caused by Mutations in the Human MYH7 Gene (2020)

Mutations in the human <i>MYH7</i> gene, encoding a slow skeletal muscle/β-cardiac myosin heavy chain, cause different types of myopathies. The nematode model <i>Caenorhabditis elegans</i> has frequently been employed to study the molecular and physiological consequences of <i>MYH7</i> mutations in muscle function by introducing mutations into the <i>unc-54</i> gene, the worm <i>MYH7</i> ortholog. We report here that the <i>C. elegans</i> model is not appropriate for such studies if they involve expression of the UNC-54 protein (wild-type or fused to green fluorescent protein) above endogenous levels.
Agent-based control of a DC MicroGrid (2013)

A lab-scale hardware DC MicroGrid system has been designed and built as part of a suite of electrical grid simulation environments. It is intended for use as an educational tool and in research as a testbed for control strategy development. The testbed has the capability to rapidly transition between hardware and software simulation of the DC MicroGrid system and consists of three components: Software in the Loop Simulation (SILS), Hardware in the Loop Simulation (HILS), and Hardware. SILS uses a PLC emulator and a Simulink model to simulate the plant and control system. In HILS, the emulator is replaced with an actual hardware controller. In the transition from HILS to hardware, a software switch shifts the PLC I/O from the model to the PLC I/O modules connected to the DC MicroGrid. In tandem with the PLC ladder code, Rockwell Automation's agent-based distributed control software enables the investigation of complex interactions between autonomous decision makers on the grid.
Thermoelectrics from Abundant Chemical Elements: High-Performance Nanostructured PbSe–PbS (2011)

We report promising thermoelectric properties of the rock salt PbSe-PbS system which consists of chemical elements with high natural abundance. Doping with PbCl(2), excess Pb, and Bi gives n-type behavior without significantly perturbing the cation sublattice. Thus, despite the great extent of dissolution of PbS in PbSe, the transport properties in this system, such as carrier mobilities and power factors, are remarkably similar to those of pristine n-type PbSe in fractions as high as 16%. The unexpected finding is the presence of precipitates ~2-5 nm in size, revealed by transmission electron microscopy, that increase in density with increasing PbS concentration, in contrast to previous reports of the occurrence of a complete solid solution in this system. We report a marked impact of the observed nanostructuring on the lattice thermal conductivity, as highlighted by contrasting the experimental values (~1.3 W/mK) to those predicted by Klemens-Drabble theory at room temperature (~1.6 W/mK). Our thermal conductivity results show that, unlike in PbTe, optical phonon excitations in PbSe-PbS systems contribute to heat transport at all temperatures. We show that figures of merit reaching as high as ~1.2-1.3 at 900 K can be obtained, suggesting that large-scale applications with good conversion efficiencies are possible from systems based on abundant, inexpensive chemical elements.
Immunogenicity of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in nonresponders to licensed hepatitis B vaccine (2013)

An additional one to three doses of hepatitis B vaccine are recommended for nonresponders to an initial standard three-dose series. We compared the safety and immunogenicity of an investigational hepatitis B surface antigen vaccine (HBsAg-1018) with a phosphorothioate oligodeoxyribonucleotide adjuvant that targets toll-like receptor-9 to a commercially available, alum-adjuvanted hepatitis B vaccine (HBsAg-Eng) in nonresponders to three previous doses (primary study) or to four to six previous doses (substudy) of HBsAg-Eng. Both vaccines were well tolerated, although HBsAg-1018 was associated with more injection-site tenderness (63.2% vs. 18.8%, p = 0.016 in the primary study and 81.8% vs. 15.4%, p = 0.003 in the substudy). No statistically significant differences in rates of seroprotection (anti-HBs concentration ≥ 10 mIU/mL) or geometric mean antibody concentrations were found in the primary study. In the substudy, a greater proportion of HBsAg-1018 recipients achieved an anti-HBs concentration ≥ 100 mIU/mL (54.5% vs. 8.3%, p = 0.027), and those responders had higher geometric mean antibody concentrations at 4 weeks (264 vs. 46.5 mIU/mL, p = 0.021) and 52 weeks (7.0 vs. 1.2 mIU/mL, p = 0.030) than HBsAg-Eng recipients. Although this study suggests that HBsAg-1018 may have improved immunogenicity in nonresponders to hepatitis B vaccine vaccination when compared with HBsAg-Eng, larger studies are required.
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study (2019)

Early intensification with postinduction myeloid-type chemotherapy courses did not significantly improve outcome for infant ALL compared with the lymphoid-type course IB. Outcome for infant ALL in Interfant-06 did not improve compared with that in Interfant-99.
Unimolecular decomposition of t-butylhydroperoxide by direct excitation of the 6–0 O—H stretching overtone (1983)

The kinetics of the unimolecular decomposition of t-butylhydroperoxide [(CH3)3COOH] have been investigated when energy is deposited into 6 quanta of the O—H stretch, causing fission of the O—O bond. The 6–0 O—H overtone is pumped at 532 nm and the appearance of one of the ultimate products, t-butyl alcohol, is detected using optoacoustic spectroscopy to follow the reaction in situ. The results of the present work are compared with previous dissociation studies using direct overtone pumping at both 532 and 619 nm. The appearance rate of t-butyl alcohol as a function of pressure is not consistent with an R.R.K.M. treatment based on simple Stern–Volmer kinetics, but can be adequately fit by invoking collisional transfer to an electronic state, which decomposes more rapidly than the ground state, and/or invoking non-statistical behaviour.
Nickel‐ or Cobalt‐Catalyzed Cross‐Coupling of Arylsulfonic Acid Salts with Grignard Reagents (2015)

Abstract The use of arylsulfonic acid salts as electrophiles in a nickel‐ or cobalt‐catalyzed cross‐coupling with Grignard reagents is described. Bis(tricyclohexylphosphine)nickel dichloride [NiCl 2 (PCy 3 ) 2 ] was found to be the optimal catalyst, and reactions with this catalyst proceeded in most cases at room temperature. The analogous cobalt catalyst [CoCl 2 (PCy 3 ) 2 ] was also found to promote the cross‐coupling reaction at higher temperature (60 °C). magnified image
Phosphorescence Lifetime Tomography in Optically Heterogeneous Media (2008)

We have previously demonstrated that phosphorescence lifetime imaging (PLI) allows unbiased determination of absolute oxygen levels (pO2) in turbid homogeneously absorbing/scattering media. Herein we show computationally that tomographic PLI can perform equally well in heterogeneous environments relying only on surface measurements of phosphorescence.
Beneficial Effects of Exclusive Enteral Nutrition in Crohnʼs Disease Are not Mediated by Faecalibacterium prausnitzii (2014)

International audience
Microlens fabrication using HEBS glass for compact high-resolution IR imaging system (2006)

Under the DARPA COMP-I (Compressive Optical MONTAGE Photography Initiative) program, the goal of this project is to significantly reduce the volume and form factor of infrared imaging systems without loss of resolution. The approach taken is to use an array of small lenses with extremely short focal lengths rather than the conventional approach of a single aperture lens system with large diameter and focal length. The array of lenses creates multiple copies of the scene on a single focal plane detector array, which are then used to reconstruct an image with resolution comparable to or higher than that of the conventional imaging system. This is achieved by a computational method known as super-resolution reconstruction. Work at the University of Delaware towards this end includes participation in the design and optimization of the optical system along with fabrication of some of the optical elements. Grayscale lithography using a high-energy beam sensitive (HEBS) glass photomask and proportional dry etch pattern transfer are the key techniques enabling the fabrication process. In this paper we will discuss the design of the imaging system while focusing on the fabrication aspects of the project.
Startup Simulation of the TOPAZ-II Reactor System for Accident Conditions (1994)

The Thermionic Transient Analysis Model (TITAM) is used in this paper to simulate the startup of the TOPAZ‐II space nuclear power system for a postulated accident condition. The temperature feedback effects of the moderator, UO2 fuel, electrodes, coolant, and other components in the core are calculated using the most recent temperature coefficient data. The reactor behavior predicted by TITAM for a normal startup is in agreement with Russian data for TOPAZ‐II. In the accident investigated, the control drums, starting in the full in position, rotate out at maximum speed of 1.4°/s to the full out position and remain out. The combination of the prompt negative coefficient of reactivity and the very low cold excess reactivity resulted in a predicted gradual rise in temperature rather than a prompt critical excursion.
Cluster formation among small resting B lymphocytes leading to B cell activation (1989)

Intercellular contacts are thought to be a crucial event in various aspects of immune responses. We have recently suggested that the self class II MHC-restricted B-B cell interaction is a prerequisite process in the polyclonal B cell differentiation induced by a novel T cell-derived lymphokine B151-TRF2 or LPS. The results have led us to the possibility that such a class II MHC-restricted B-B cell interaction promotes the formation of B cell clusters responsible for the development of IgM-producing cells upon subsequent stimulation with the polyclonal B cell activator. To examine directly this possibility, the present study has utilized a recently devised ACAS470 work station capable of sorting out desired cells in a tissue culture plate in situ. Clusters and non-clusters were observed after 2 day preculture of murine resting B cells in the absence of the polyclonal B cell activator. Interestingly, B cells in clusters purified by the ACAS470 gave rise to IgM-producing cells when stimulated with B151-TRF2 or LPS for an additional 2 days, whereas non-clustered B cells failed to differentiate. Moreover, such a B cell activation was not observed when the 2 day preculture of the resting B cells was conducted in the presence of anti-class II MHC mAb but not of anti-class I MHC mAb. Thus, the present results support the notion that cluster formation among small resting B cells accompanying the class II MHC-restricted B-B cell interaction makes the B cells responsive to differentiation signals of polyclonal B cell activator.
Laser diode active height control system for data storage applications (2006)

We describe and characterize an active height control system for near-field data storage applications using a commercial laser diode as a direct position sensor. The self-mixing interference signal was experimentally characterized and the effective spot size of the laser sensor was also measured. A control system utilizing interference in the laser as feedback signal was constructed to drive a conventional DVD pickup with the laser sensor mounted. The residual position error is ±9nm when the rotation speed of a glass disk was 1500rpm and the vertical runout was 16&#956;m. The approach limit was estimated to be 25nm when the laser size is reduced to 100&#956;m.
Ileal pouch anal anastomosis and the problem of pouchitis (1997)

Ileal pouchanal anastomosis (IPAA) has emerged as the procedure of choice for patients with ulcerative colitis and most patients with familial adenomatous polyposis. Patients over 60 appear to tolerate IPAA well and have functional results comparable to those achieved in younger patients. The distribution of disease in the colon does not appear to affect outcomes after IPAA. For most patients with familial adenomatous polyposis, IPAA is safe and provides functional results comparable to those achieved with ileorectostomy. The double-stapled IPAA technique now appears to be safe and to provide better functional results in terms of incontinence than the hand-sewn technique. Variations of IPAA technique, including anorectal eversion and anal transition zone resection, are discussed. A large series of IPAA patients confirms the safety and efficacy of IPAA. Pouch failure appears to be primarily the result of uncontrolled fistula and poor function. Nonspecific inflammation of the pouch (pouchitis) is the most frequent long-term complication of abdominal colectomy with ileal pouch-anal anastomosis for ulcerative colitis. The 10-year cumulative risk of pouchitis in patients with ulcerative colitis with and without associated primary sclerosing cholangitis is 46% and 79%, respectively. Smoking protects against pouchitis. The preoperative extent of ulcerative colitis does not predict pouchitis. In contrast to previous reports, recent studies show no association between pouchitis and perinuclear antineutrophil cytoplasmic antibodies. Similar to patients with ulcerative colitis, patients with pouchitis have increased pouch mucosal concentrations of leukotriene B4 and cytokines, increased serum concentrations of adhesion molecules, and increased intestinal permeability. Fecal concentrations of bile acids and bacteria do not predict pouchitis. Most patients with pouchitis will respond to metronidazole or ciprofloxacin. Dysplasia occurred in 3% of 87 patients undergoing surveillance endoscopy of the ileoanal pouch after a mean of 6 years of follow-up.
One‐Dimensional Porous Carbon/Platinum Composites for Nanoscale Electrodes (2007)

Klein, aber fein: Die Kombination einer Templatmethode mit elektrochemischen Verfahren ermöglichte die gezielte Synthese von nanoskaligen eindimensionalen Kohlenstoff-Platin-Elektroden mit großen Oberflächen und kleinen Platinnanopartikeln, die homogen in der vernetzten porösen Kohlenstoffmatrix dispergiert sind (siehe TEM-Bilder). Die Elektroden zeigen eine ausgezeichnete katalytische Aktivität bei der Sauerstoff-Elektroreduktion.