gebhart/patrepeval huggingface dataset:
Input Current-Ripple Consideration for the Pulse-link DC-AC Converter for Fuel Cells by Small Series LC Circuit (2009)

This paper mentions the input current ripple reduction method of the Pulse-link DC-AC Converter for Fuel Cells. The conventional DC-AC converter for fuel cells is interpolated large capacitor between boost converter stage and PWM inverter stage. That capacitor disturbs the size reduction of this unit. To overcome this problem, authors have proposed a novel topology called as Pulse-link DC-AC converter. The proposed topology provides boosted-voltage pulse directly to PWM inverter. This topology does not require large capacitor between two stages. Instead, small values of inductor and capacitor are connected series and inserted between two stages in parallel. This paper examines the relationship between the inductor and capacitor values and input current-ripple. As the result, inductor value has the relationship with current-ripple.
Sparse Cellular Neugebauer Model for N-ink Printers (2006)

The number of colorants used in printers is growing to improve quality of the prints in terms of gamut size, grain and metamerism. In this paper we demonstrate a modification to the existing models (Cellular Neugebauer Model, with Yule Nielson Correction) to simulate spectral reflectance of an N-ink printer. This is achieved by imposing a constraint for the media ink limit, the modified model is shown to reduce the required number of training points by as much as 97 percent. Imposing this constraint leaves us with sparse training data set and the modified Yule-Nielson Neugebauer Spectral model is shown to handle the sparse data well with average error of 1.48 &#x394;E94.In this paper, two standard dot placement models (Dot-on-dot v.s. Demichel) are implemented and compared.
Structural insights into conserved l‐arabinose metabolic enzymes reveal the substrate binding site of a thermophilic l‐arabinose isomerase (2014)

Structural genomics demonstrates that despite low levels of structural similarity of proteins comprising a metabolic pathway, their substrate binding regions are likely to be conserved. Herein based on the 3D-structures of the α/β-fold proteins involved in the ara operon, we attempted to predict the substrate binding residues of thermophilic Geobacillus stearothermophilus L-arabinose isomerase (GSAI) with no 3D-structure available. Comparison of the structures of L-arabinose catabolic enzymes revealed a conserved feature to form the substrate-binding modules, which can be extended to predict the substrate binding site of GSAI (i.e., D195, E261 and E333). Moreover, these data implicated that proteins in the l-arabinose metabolic pathway might retain their substrate binding niches as the modular structure through conserved molecular evolution even with totally different structural scaffolds.
Surface-enhanced Raman assays (SERA): measurement of bilirubin and salicylate (1999)

Results of a study to detect bilirubin and salicylate using SERS and a reactive coating are presented. The motivation for this work was to devel to develop an assay that would simplify an analysis by detecting the analyte in a whole blood sample. This would remove the risks and time associated with preparing a serum sample. Quantitative analysis was performed using partial least-squares. The results are that one can detect bilirubin and salicylate in whole blood at levels below the normal or therapeutic levels using a coating based on an argentiphilic diazonium molecule. The sharp Raman bands associated with the analyte–coating adduct are sufficiently resolved to allow the analyte to be detected in the presence of a complex matrix such as whole blood. Copyright © 1999 John Wiley & Sons, Ltd.
Elastofibroma Dorsi (1987)

Elastofibroma dorsi is a pseudotumorous connective tissue mass that characteristically arises between the chest wall and the inferior angle of the scapula. Its long axis is typically craniocaudal. Two patients are illustrated, each presenting with a fixed subscapular mass. Computed tomography showed each mass as elongated, incompletely marginated, and of soft tissue density deep to the inferior angle of a scapula. The latissimus dorsi and an underlying layer of fat were posterolaterally elevated inferior to the tip of the scapula. After incisional biopsy excluded sarcoma, each mass was locally excised.
EELS Study of Differential Diffusion of Fe and Co in Magnetized Silica Nanocomposites (2016)

Oxygen vacancies are prevalent in amorphous silica. It is recently recognized that the diffusion of metal cations and hydrolytic weakening at the elevated temperature produced hollow framed silica with interior voids. Electron energy-loss spectroscopy (EELS) reveals more complex behaviors of metals and oxygen underneath this seemingly simple shape evolution. In Fe3O4/SiO2 nanocomposites, polyhedral distortion is severe, and the alteration of Si–O–Si bonding occurs. Ionic character is strengthened, and the oxidation number of Si decreases with increasing annealing temperature. Despite this distortion, ordering of oxygen within amorphous silica is enhanced with the increase of annealing temperature. Reduction of Fe3+ to Fe2+ is also facilitated by the diffusion of Fe3+ into SiO4 tetrahedra. In the presence of Co, however, polyhedral distortion is not severe, and it is supposed that Co not only resides on the surface of mesoporous silica but also inhibits the diffusion of Fe into SiO4 tetrahedra. In addition, Co suppresses the formation of Fe3O4 and other iron oxides, and it also retards the formation of CoFe2O4. Despite the shape reorganization in CoFe2O4/SiO2 nanocomposites, the covalent nature of SiO4 tetrahedra is maintained throughout the annealing temperature. Under the slow heating process (2.5 °C/min), however, the diffusion of Fe and Co is enhanced, and they undergo amorphous alloying with Si. Without making crystalline CoFe2O4, this alloying contributes to the formation of metallic Si. All these observations are governed by oxygen deficiency in amorphous silica and the enhanced diffusion of transition metal cations at the elevated temperature.
Transmission Properties of Hollow-Core Photonic Bandgap Fibers (2010)

Variations in optical transmission of four types of hollow-core photonic bandgap fibers are measured as a function of laser frequency. These variations influence the potential accuracy of gas sensors based on molecular spectroscopy in hollow-core fibers.
Imbalance in multiple sclerosis: A result of slowed spinal somatosensory conduction (2008)

Balance problems and falls are common in people with multiple sclerosis (MS) but their cause and nature are not well understood. It is known that MS affects many areas of the central nervous system that can impact postural responses to maintain balance, including the cerebellum and the spinal cord. Cerebellar balance disorders are associated with normal latencies but reduced scaling of postural responses. We therefore examined the latency and scaling of automatic postural responses, and their relationship to somatosensory evoked potentials (SSEPs), in ten people with MS and imbalance and ten age-, sex-matched, healthy controls. The latency and scaling of postural responses to backward surface translations of five different velocities and amplitudes, and the latency of spinal and supraspinal somatosensory conduction, were examined. Subjects with MS had large, but very delayed automatic postural response latencies compared to controls (161 +/- 31 ms vs. 102 +/- 21 ms, p < 0.01) and these postural response latencies correlated with the latencies of their spinal SSEPs (r = 0.73, p < 0.01). Subjects with MS also had normal or excessive scaling of postural response amplitude to perturbation velocity and amplitude. Longer latency postural responses were associated with less velocity scaling and more amplitude scaling. Balance deficits in people with MS appear to be caused by slowed spinal somatosensory conduction and not by cerebellar involvement. People with MS appear to compensate for their slowed spinal somatosensory conduction by increasing the amplitude scaling and the magnitude of their postural responses.
Energy conversion options for ARIES-III-a conceptual D-/sup 3/He tokamak reactor (2003)

High-efficiency energy conversion schemes for a D-/sup 3/He tokamak reactor are investigated. The loss channels for a D-/sup 3/He plasma are through charged particles, neutrons, and radiation (synchrotron and bremsstrahlung), with only a few percent of the energy loss in neutrons. In contrast to D-T fusion reactors, this gives high leverage to energy-conversion methods which apply to charged particles or radiation. The ideas investigated focus on efficiently converting such energy to electricity or on converting thermal energy in ways which make effective use of fusion-reactor characteristics such as high magnetic fields. The energy-conversion methods investigated are given. Whether a concept was chosen for further study is indicated, as is the applicability of the concept to the three tokamak versions under consideration for the Advanced Reactor Innovation and Evaluation Study-III (ARIES-III): a high-field reactor (HFR), a second stability reactor (SSR), and a spherical torus (ST). Options not selected for further pursuit within the ARIES project are described briefly, and those selected are discussed more extensively. Selection criteria include cost, efficiency, technical feasibility, and how well a concept made use of fusion-specific features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Active Distribution Grids offering Ancillary Services in Islanded and\n Grid-connected Mode (2019)

Future active distribution grids (ADGs) will incorporate a plethora of\nDistributed Generators (DGs) and other Distributed Energy Resources (DERs),\nallowing them to provide ancillary services in grid-connected mode and, if\nnecessary, operate in an islanded mode to increase reliability and resilience.\nIn this paper, we investigate the ability of an ADG to provide frequency\ncontrol (FC) in grid-connected mode and ensure reliable islanded operation for\na pre-specified time period. First, we formulate the operation of the grid\nparticipating in European-type FC markets as a centralized multi-period optimal\npower flow problem with a rolling horizon of 24 hours. Then, we include\nconstraints to the grid-connected operational problem to guarantee the ability\nto switch to islanded operation at every time instant. Finally, we explore the\ntechnical and economic feasibility of offering these services on a balanced\nlow-voltage distribution network. The results show that the proposed scheme is\nable to offer and respond to different FC products, while ensuring that there\nis adequate energy capacity at every time step to satisfy critical load in the\nislanded mode.\n
Energy-efficient and high-performance software architecture for storage class memory (2013)

Recently, interest in incorporating Storage Class Memory (SCM), which blurs the distinction between memory and storage, into mainstream computing has been increasing rapidly. In this paper, we address the emerging questions regarding the use of SCM. Based on an embedded platform that employs FeRAM, a type of SCM, we present our findings. In summary, by introducing SCM, power efficiency improves while performance is degraded. We also show that such performance degradations may be removed with operating system level schemes that fully exploit the characteristics of SCM. Finally, we present permanent computing that supports lightweight system on/off capabilities by using SCM.
Preliminary Resultson the use of Autologous Cell Culture Grafts of Buccal Mucosa in Urethral Repairs (2012)

We report the procedure in order to obtain and use an MB homologous cell culture. Using autologous material reduced the surgical time and wiped out the risk of rejection; on the other hand, the tissue was so thin and with no adequate scaffold that the healing retraction of the graft was increased, thus compromising the urethral reconstruction. Preliminary results confirm that bio- engineering applied to urethral surgery is far from obtaining adequate tissue with reference to extension, thickness and biological features.
Receiver Sensitivity of Advanced Modulation Formats for 40 Gb/s DWDM Transmission with and without FEC (2006)

Receiver sensitivity of a wide range of current modulation formats including multi-level formats and coherent detection is studied by extensive Monte-Carlo simulations and by experiment. Required OSNR for BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> with and without FEC is determined.
Linear dynamical neural population models through nonlinear embeddings (2016)

A body of recent work in modeling neural activity focuses on recovering low-dimensional latent features that capture the statistical structure of large-scale neural populations. Most such approaches have focused on linear generative models, where inference is computationally tractable. Here, we propose fLDS, a general class of nonlinear generative models that permits the firing rate of each neuron to vary as an arbitrary smooth function of a latent, linear dynamical state. This extra flexibility allows the model to capture a richer set of neural variability than a purely linear model, but retains an easily visualizable low-dimensional latent space. To fit this class of non-conjugate models we propose a variational inference scheme, along with a novel approximate posterior capable of capturing rich temporal correlations across time. We show that our techniques permit inference in a wide class of generative models.We also show in application to two neural datasets that, compared to state-of-the-art neural population models, fLDS captures a much larger proportion of neural variability with a small number of latent dimensions, providing superior predictive performance and interpretability.
Developing a treatment planning process and software for improved translation of photodynamic therapy (2017)

Background: The majority of de novo cancers are diagnosed in low and middle-income countries, which often lack the resources to provide adequate therapeutic options. None or minimally invasive therapies such as Photodynamic Therapy (PDT) or photothermal therapies could become part of the overall treatment options in these countries. However, widespread acceptance is hindered by the current empirical training of surgeons in these optical techniques and a lack of easily usable treatment optimizing tools. Methods: Based on image processing programs, ITK-SNAP, and the publicly available FullMonte light propagation software, a work plan is proposed that allows for personalized PDT treatment planning. Starting with, contoured clinical CT or MRI images, the generation of 3D tetrahedral models in silico, execution of the Monte Carlo simulation and presentation of the 3D fluence rate, &Phi;, [mWcm<sup>-2</sup>] distribution a treatment plan optimizing photon source placement is developed. Results: Permitting 1-2 days for the installation of the required programs, novices can generate their first fluence, H [Jcm<sup>-2</sup>] or &Phi; distribution in a matter of hours. This is reduced to 10th of minutes with some training. Executing the photon simulation calculations is rapid and not the performance limiting process. Largest sources of errors are uncertainties in the contouring and unknown tissue optical properties. Conclusions: The presented FullMonte simulation is the fastest tetrahedral based photon propagation program and provides the basis for PDT treatment planning processes, enabling a faster proliferation of low cost, minimal invasive personalized cancer therapies.
Effect of Bradykinin and Tachykinin Receptor Antagonist on Xylene-Induced Cystitis in Rats (1993)

The effects of the bradykinin receptor selective antagonist, Hoe 140, and of the tachykinin NK-1 receptor antagonist (+/-)CP 96,345 were investigated in a rat model of chemically-induced cystitis (intravesical instillation of xylene in female rats). Intravenous injection of bradykinin (1 mumol./kg.) or substance P (3 nmol./kg.) produced plasma protein extravasation (PPE) in the rat urinary bladder. Bradykinin response was prevented by Hoe 140 (100 nmol./kg. intravenously) and unaffected by (+/-)CP 96,345 (10 mumol./kg. intravenously). Plasma protein extravasation produced by substance P was inhibited by (+/-)CP 96,345 but unchanged by Hoe 140. Catheterization required for intravesical xylene instillation into the female rat bladder produced per se an inflammatory response which was abolished by either Hoe 140 or (+/-)CP 96,345. Intravesical instillation of xylene produced a large PPE response which was reduced by about 65% by Hoe 140 or (+/-)CP 96,345. Combined administration of the two antagonists produced an additive effect on the PPE response to xylene. We conclude that both bradykinin and tachykinins are involved in the inflammatory reaction of the rat urinary bladder to catheterization and xylene irritation.
Plasma Membrane Domains Specialized for Clathrin-mediated Endocytosis in Primary Cells (2006)

Clathrin assembly at the plasma membrane is a fundamental process required for endocytosis. In cultured cells, most of the clathrin is localized to large patches that display little lateral mobility. The functional role of these regions is not clear, and it has been thought that they may represent artifacts of cell adhesion of cultured cells. Here we have analyzed clathrin organization in primary adipose cells isolated from mice, which are nonadherent and fully differentiated. The majority of clathrin on the plasma membrane of these cells (>60%) was found in large clathrin patches that displayed virtually no lateral mobility and persisted for many minutes, and a smaller amount was found in small spots that appeared and disappeared rapidly. Direct visualization of transferrin revealed that it bound onto large arrays of clathrin, internalizing through vesicles that emerge from these domains. High resolution imaging (50 images/s) revealed fluorescence intensity fluctuations consistent with the formation and detachment of coated vesicles from within large patches. These results reveal that large clathrin assemblies are active regions of endocytosis in mammalian cells and highlight the importance of understanding the mechanistic basis for this organization.
S809 A Higher Induction Dosing Regimen of Adalimumab Does Not Enhance Modulation of Downstream Blood Molecular Markers in Patients With Moderately to Severely Active Crohn’s Disease or Ulcerative Colitis (2021)

Introduction: We report proteomic and transcriptomic analyses for adalimumab (ADA) higher induction dosing regimen (HIR) and standard induction dosing regimen (SIR) in patients (pts) with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC). Methods: In SERENE-CD and SERENE-UC, pts were randomized to ADA HIR(160mg, Wks 0, 1, 2, and 3) or SIR(160mg, Wk0 and 80mg Wk2) then 40mg EOW from wk4 onwards. In SERENE-CD, co-primary endpoints were proportion of pts achieving clinical remission (CR [Crohn’s Disease Activity Index < 150]) at Wk4, and endoscopic response (decrease in Simplified Endoscopic Score for Crohn’s Disease [SES-CD] >50% from baseline [BL] or, if BL SES-CD=4, ≥2-point reduction from BL) at Wk12. Primary endpoint in SERENE-UC was proportion of pts achieving CR(Full Mayo score≤2 with no subscore >1) at Wk8. ADA trough serum concentrations were measured at Wks2, 4, 8, 12(SERENE-CD) and Wks2, 4, 8 (SERENE-UC). Biomarker analyses on population subset included monitoring modulation of 184 serum proteins (Olink Inflammation and Immune response panels) and 23 additional plasma proteins that showed changes in other ADA indications. Analyses compared BL to Wk12 (SERENE-CD) or Wk8 (SERENE-UC), including OSM, TREM1, IL-6, TNFa, and IFNg markers. A two-sample t-test compared Wk8 (SERENE-UC) or Wk12 (SERENE-CD) change from BL. Changes in whole blood gene expression were evaluated. Results: SERENE-CD included 270/514 pts (HIR: 124; SIR: 116). SERENE-UC included 194/851 pts (HIR: 117; SIR: 77). BL demographics were generally well balanced across groups. ADA trough serum concentrations were higher in HIR vs SIR groups throughout induction period in both studies. Changes in serum protein levels from BL to Wk12 (SERENE-CD) or Wk8 (SERENE-UC) across a panel of 207 immunomodulatory proteins of interest were not significantly different between dosing regimens in either study. Changes in circulating TNF levels from BL to Wk12 (SERENE-CD) or Wk8 (SERENE-UC) were not significantly different with HIR in either study. No significantly differentially expressed genes were found in whole blood between dosing regimens in either study, indicating no evidence of enhanced gene modulation with HIR. Conclusion: HIR resulted in increased ADA serum concentration vs SIR in both SERENE-CD and SERENE-UC, but this did not translate into increased efficacy of induction treatment. HIR did not influence peripheral blood molecular markers at the gene/ protein level at clinical and endoscopic endpoints vs SIR.
β‐amyloid in lewy body disease is related to Alzheimer's disease‐like atrophy (2012)

The aim of this study was to investigate whether amyloid deposition is associated with Alzheimer's disease (AD)‐like cortical atrophy in Lewy body (LB) disease (LBD). Participants included 15 LBD with dementia patients (8 with dementia with Lewy bodies [DLB] and 7 with Parkinson's disease [PD] with dementia [PDD]), 13 AD patients, and 17 healthy controls. Age, gender, and Mini–Mental State Examination scores were matched between patient groups. All subjects underwent PET scans with [ 11 C]Pittsburgh Compound B to measure brain amyloid deposition as well as three‐dimensional T1‐weighted MRI. Gray‐matter volumes (GMVs) were estimated by voxel‐based morphometry. Volumes‐of‐interest analyses were also performed. Forty percent of the 15 DLB/PDD patients were amyloid positive, whereas all AD patients and none of the healthy controls were amyloid positive. Amyloid‐positive DLB/PDD and AD patients showed very similar patterns of cortical atrophy in the parahippocampal area and lateral temporal and parietal cortices, with 95.2% of cortical atrophy distribution being overlapped. In contrast, amyloid‐negative DLB/PDD patients had no significant cortical atrophy. Compared to healthy controls, parahippocampal GMVs were reduced by 26% in both the amyloid‐positive DLB/PDD and AD groups and by 10% in the amyloid‐negative DLB/PDD group. The results suggest that amyloid deposition is associated with AD‐like atrophy in DLB/PDD patients. Early intervention against amyloid may prevent or delay AD‐like atrophy in DLB/PDD patients with amyloid deposition. © 2012 Movement Disorder Society
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study (2009)

The binding of a series of novel benzodioxanes, structurally related to WB4101, was examined by means of 2D, 3D-QSAR together with docking studies. Multiple regression analysis suggested the relevance of adequate polar atoms on antagonist scaffold and of passive membrane diffusion to enhance affinity towards α1D-adrenergic receptors. Docking simulations against a computational structural model of the biological target further proved this evidence and furnished support for chemiometric analysis, where polar, electrostatic, hydrophobic and shape effects, most likely governing ligand binding, helped the depiction of pharmacophore hypothesis for the examined ligands data set.