gebhart/patrepeval huggingface dataset:
A Review of AI-Based Radiomics and Computational Pathology Approaches in Triple-Negative Breast Cancer: Current Applications and Perspectives (2023)

Breast cancer is one of the most common and deadly cancers worldwide. Approximately, 20% of all breast cancers are characterized as triple negative (TNBC). TNBC typically is associated with a poorer prognosis relative to other breast cancer subtypes. Due to its aggressiveness and lack of response to hormonal therapy, conventional cytotoxic chemotherapy is the usual treatment; however, this treatment is not always effective, and an important percentage of patients develop recurrence. More recently, immunotherapy has started to be used on some populations with TNBC showing promising results. Unfortunately, immunotherapy is only applicable to a minority of patients and responses in metastatic TNBC have overall been modest in comparison to other cancer types. This situation evidences the need for developing effective biomarkers that help to stratify and personalize patient management. Thanks to recent advances in artificial intelligence (AI), there has been an increasing interest in its use for medical applications aiming at supporting clinical decision making. Several works have used AI in combination with diagnostic medical imaging, more specifically radiology and digitized histopathological tissue samples, aiming to extract disease-specific information that is difficult to quantify by the human eye. These works have demonstrated that analysis of such images in the context of TNBC has great potential for (1) risk-stratifying patients to identify those patients who are more likely to experience disease recurrence or die from the disease and (2) predicting pathologic complete response. In this manuscript, we present an overview on AI and its integration with radiology and histopathological images for developing prognostic and predictive approaches for TNBC. We present state of the art approaches in the literature and discuss the opportunities and challenges with developing AI algorithms regarding further development and clinical deployment, including identifying those patients who may benefit from certain treatments (e.g., adjuvant chemotherapy) from those who may not and thereby should be directed toward other therapies, discovering potential differences between populations, and identifying disease subtypes.
Keynote Lecture 2 “Opportunities for Natural Product Sciences in Modern Drug Discovery” (2022)

Nature is still a non-exhausted source for new pharmacophores. In recent year several launches of new drugs like Ixempra™, Rydapt™ or Cubicin™ are based on natural products, showing the high impact of natural product research on drug discovery in different therapeutic areas.
Optical absorption and stimulated emission of neodymium in yttrium orthosilicate (1990)

A spectroscopic investigation of the biaxial crystal yttrium orthosilicate doped with Nd/sup 3+/(Nd/sup 3+/:Y/sub 2/SiO/sub 5/) has been performed. Spectrally and orientationally resolved emission cross sections necessary for the evaluation of laser performance on the Nd/sup 3+/ /sup 4/F/sub 3/2/-/sup 4/I/sub 9/2/ and /sup 4/F/sub 3/2-//sup 4/I/sub 11/2/ transitions have been determined. The Judd-Ofelt theory has been applied to measured values of optical absorption line strengths to obtain the orientation averaged intensity parameters: Omega /sub 2/-3.34*10/sup -20/ cm/sup 2/, Omega /sub 4/=4.35*10/sup -20/ cm/sup 2/, and Omega /sub 6/=5.60*10/sup -20/ cm/sup 2/. These Judd-Ofelt intensity parameter values are significantly different from those previously reported by A.M. Tkachuk et al. Using these intensity parameters, the Nd/sup 3+/ /sup 4/F/sub 2/ metastable state lifetime is predicted to be 225 mu s. Measured low Nd concentration /sup 4/F/sub 3/2/ lifetimes of 214 mu s indicate a high radiative quantum efficiency. Because of the Stark level splitting of the Nd/sup 3+/ /sup 4/F/sub 3/2/ and /sup 4/I/sub 9/2/ manifolds, laser operation at twice one of the Cs atomic resonance filter acceptance wavelengths is possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A personalized search engine based on web-snippet hierarchical clustering (2005)

In this paper we propose a hierarchical clustering engine, called snaket, that is able to organize on-the-fly the search results drawn from 16 commodity search engines into a hierarchy of labeled folders. The hierarchy offers a complementary view to the flat-ranked list of results returned by current search engines. Users can navigate through the hierarchy driven by their search needs. This is especially useful for informative, polysemous and poor queries.SnakeT is the first complete and open-source system in the literature that offers both hierarchical clustering and folder labeling with variable-length sentences. We extensively test SnakeT against all available web-snippet clustering engines, and show that it achieves efficiency and efficacy performance close to the best known engine Vivisimo.com.Recently, personalized search engines have been introduced with the aim of improving search results by focusing on the users, rather than on their submitted queries. We show how to plug SnakeT on top of any (un-personalized) search engine in order to obtain a form of personalization that is fully adaptive, privacy preserving, scalable, and non intrusive for underlying search engines.
Chiral Nematic Liquid Crystalline Sensors Containing Responsive Dopants (2017)

In his 1990 book, Peter Collings refers to liquid crystals (LCs) as “Nature's delicate phase of matter.”1 This is perhaps most apparent when looking at the use of LCs as sensors. Due to the inherent fragility of the phase, LCs make ideal candidates for sensors, as small disruptions to the localized order are propagated and amplified throughout the bulk material. This responsiveness, coupled with the attractive optical properties of liquid crystalline materials, has been the focus of much of the investigation into the applications of the liquid crystalline phase.
Introduction to the Issue on Information-Theoretic Methods in Data Acquisition, Analysis, and Processing (2018)

The twenty papers that are included in this special section explore applications of information theoretic methods to emerging data science problems. In particular, the papers cover a wide range of topics that can broadly be organized into four themes: (1) data acquisition, (2) data analysis and processing, (3) statistics and machine learning, and (4) privacy and fairness.
ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection (2015)

Current knowledge of stem cell characteristics, maintenance and renewal, evolution with age, location in 'niches', and radiosensitivity to acute and protracted exposures is reviewed regarding haematopoietic tissue, mammary gland, thyroid, digestive tract, lung, skin, and bone. The identity of the target cells for carcinogenesis continues to point to the more primitive and mostly quiescent stem cell population (able to accumulate the protracted sequence of mutations necessary to result in malignancy), and, in a few tissues, to daughter progenitor cells. Several biological processes could contribute to the protection of stem cells from mutation accumulation: (1) accurate DNA repair; (2) rapid induced death of injured stem cells; (3) retention of the intact parental strand during divisions in some tissues so that mutations are passed to the daughter differentiating cells; and (4) stem cell competition, whereby undamaged stem cells outcompete damaged stem cells for residence in the vital niche. DNA repair mainly operates within a few days of irradiation, while stem cell replications and competition require weeks or many months depending on the tissue type. This foundation is used to provide a biological insight to protection issues including the linear-non-threshold and relative risk models, differences in cancer risk between tissues, dose-rate effects, and changes in the risk of radiation carcinogenesis by age at exposure and attained age.
Fat Density in Renal Cell Carcinoma: Demonstration with Computerized Tomography (1997)

No AccessJournal of UrologyClinical Urology: Case Report1 Apr 1997Fat Density in Renal Cell Carcinoma: Demonstration with Computerized Tomography Jonathan R. Henderson, Raymond Germany, Patrick W. Peavy, James A. Eastham, and Dennis D. Venable Jonathan R. HendersonJonathan R. Henderson , Raymond GermanyRaymond Germany , Patrick W. PeavyPatrick W. Peavy , James A. EasthamJames A. Eastham , and Dennis D. VenableDennis D. Venable View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64970-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Fat Density in Renal Cell Carcinoma: Demonstration with Computerized Tomography." The Journal of Urology, 157(4), pp. 1347–1348 References 1 : CT demonstration of fat density in renal cell carcinoma. Acta Rad.1992; 33: 365. Google Scholar 2 : Intratumoral fat in a renal cell carcinoma. Letter to the Editor. AJR1991; 156: 871. Google Scholar 3 : Renal cell carcinoma containing fat: demonstration with CT. Radiology1993; 188: 429. Google Scholar 4 : Detection of fat in a renal cell carcinoma mimicking angiomyolipoma. Radiology1993; 188: 427. Crossref, Medline, Google Scholar From the Departments of Urology and Radiology, Louisiana State University Medical Center, and Schumpert Medical Center, Shreveport, Louisiana© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMilner J, McNeil B, Alioto J, Proud K, Rubinas T, Picken M, Demos T, Turk T and Perry K (2018) Fat Poor Renal Angiomyolipoma: Patient, Computerized Tomography and Histological FindingsJournal of Urology, VOL. 176, NO. 3, (905-909), Online publication date: 1-Sep-2006.WOLF J (2018) EVALUATION AND MANAGEMENT OF SOLID AND CYSTIC RENAL MASSESJournal of Urology, VOL. 159, NO. 4, (1120-1133), Online publication date: 1-Apr-1998.Bisignani G, Hardesty L, Hartman D and Jarowenko M (2018) PERINEPHRIC ABSCESS MASQUERADING AS AN ANGIOMYOLIPOMAJournal of Urology, VOL. 159, NO. 2, (500-500), Online publication date: 1-Feb-1998. Volume 157Issue 4April 1997Page: 1347-1348 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Jonathan R. Henderson More articles by this author Raymond Germany More articles by this author Patrick W. Peavy More articles by this author James A. Eastham More articles by this author Dennis D. Venable More articles by this author Expand All Advertisement PDF downloadLoading ...
Arterial pulse wave velocity in elderly patients with dementia (2002)

Background: Cardiovascular events influence the quality of life and mortality of elderly patients. Arterial stiffness measured by aortic pulse wave velocity is a useful means of predicting the presence of cardiovascular diseases, even in subjects over 70 years old. This procedure is non‐invasive, but the usefulness and easiness of aortic pulse wave velocity for patients with dementia are still unclear. Therefore, to determine how useful and easy it is to measure aortic pulse wave velocity, we evaluated arterial stiffness in patients with or without dementia who required care and support for their daily life. Methods: Fifty‐nine subjects over 70‐years‐old who suffered from dementia were enrolled in this study. After we excluded arteriosclerosis obliterans (ankle‐brachial pressure index &lt; 0.80; n = 10) by arterial pulse wave velocity, we classified these subjects into two groups: subjects with Alzheimer's disease ( n = 25) and subjects with vascular dementia ( n = 24) who were diagnosed by magnetic resource imaging and mini‐mental state examination. Results: The authors of the present paper could easily and precisely evaluate arterial stiffness of all patients. The mean pulse wave velocity of right and left brachial‐tibial arteries in subjects with Alzheimer's disease (1740 ± 385 cm/s) was significantly lower than those subjects with vascular dementia (2436 ± 586; P &lt; 0.001). Conclusion: The data included in the present study indicate that subjects with Alzheimer's disease had decreased arterial stiffness and would show a lower risk of cardiovascular diseases compared to subjects with other diseases including vascular dementia.
Dammarane-Type Saponins from the Flower Buds ofPanax ginsengand Their Intracellular Radical Scavenging Capacity (2009)

Korean ginseng (Panax ginseng C.A. Meyer) has been extensively used as a functional food for thousands of years. This study with the aim to evaluate the potential of P. ginseng flower components as a functional food with medicinal properties resulted in the identification of three new dammarane-type saponins, named floralginsenosides Ka-Kc (1-3), along with seventeen known ones (4-20). Their structures were elucidated on the basis of chemical and spectroscopic methods, and their antioxidant activities were evaluated by the intracellular ROS radical scavenging DCF-DA assay. Among them, floralginsenoside Ka (1) displayed potent scavenging activity with the inhibition value of 64% at 10 microM; and ginsenoside Rb(1) (13), floralginsenoside Kc (3), floralginsenoside Kb (2), vinaginsenoside R(9) (11), majoroside F(1) (12), ginsenoside I (17), and ginsenoside II (18) showed moderate scavenging capacity with the inhibition rate of 28, 33, 35, 35, 35, 38, and 38% at 10 microM, respectively. These results warrant further studies concerning the potential of saponin extracts of P. ginseng flowers for functional foods.
氮管理中的脱碳潜力 (2023)

The water sector is in the middle of a paradigm shift from focusing on treatment and meeting discharge permit limits to integrated operation that also enables a circular water economy via water reuse, resource recovery, and system level planning and operation. While the sector has gone through different stages of such revolution, from improving energy efficiency to recovering renewable energy and resources, when it comes to the next step of achieving carbon neutrality or negative emission, it falls behind other infrastructure sectors such as energy and transportation. The water sector carries tremendous potential to decarbonize, from technological advancements, to operational optimization, to policy and behavioural changes.This book aims to fill an important gap for different stakeholders to gain knowledge and skills in this area and equip the water community to further decarbonize the industry and build a carbon-free society and economy. The book goes beyond technology overviews, rather it aims to provide a system level blueprint for decarbonization. It can be a reference book and textbook for graduate students, researchers, practitioners, consultants and policy makers, and it will provide practical guidance for stakeholders to analyse and implement decarbonization measures in their professions.English edition available https://iwaponline.com/ebooks/book/843/Pathways-to-Water-Sector-Decarbonization-Carbon
Optical Fiber Chemical Sensors for Process and Environmental Monitoring (2012)

Ion-selective optodes offer potential for in-line monitoring of various processes. Fiber sensors were developed for H+, Ca2+, K+, Na+, NH4+ and NO3−. Applications in hydroponic culture optimization, soil characterization and anaerobic digester process control were demonstrated.
Evolution of LTE toward IMT-advanced (2011)

This article provides a high-level overview of LTE Release 10, sometimes referred to as LTE-Advanced. First, a brief overview of the first release of LTE and some of its technology components is given, followed by a discussion on the IMT-Advanced requirements. The technology enhancements introduced to LTE in Release 10, carrier aggregation, improved multi-antenna support, relaying, and improved support for heterogeneous deployments, are described. The article is concluded with simulation results, showing that LTE Release 10 fulfills and even surpasses the requirements for IMT-Advanced.
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease (2015)

YKL-40 and chitotriosidase are increased in asthma and more so in COPD. The data in the present study support these substances as being relatively steroid-insensitive, non-T-helper cell type 2-type biomarkers distinctly related to chronic inflammatory disease processes.
Supplementary Tables from A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine (2023)

&lt;p&gt;Contains Tables S1 and S2. Supplementary Table 1: List of PCR primers. Supplementary Table 2: Sensitivity of Breast Cancer Cell Lines to CPI-455 Cell Viability was measured following exposure to CPI-455 for 8 days.&lt;/p&gt;
A novel class of calcium-entry blockers: the 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines (1992)

The synthesis and initial biological evaluation of a series of 1-sulfonylindolizines is described. These compounds have been shown to be representatives of a novel class of potent, slow-channel calcium antagonists. All compounds were found to be at least as active as the reference calcium antagonists verapamil and cis-(+)-diltiazem. Structure-activity relationship studies have shown that all compounds possessing an aralkyl group in the amine moiety and an isopropyl or cyclopropyl group at the 2 position of the indolizine are among the most potent calcium antagonists known outside the 1,4-dihydropyridine series. The IC50 values for the inhibition of [3H]nitrendipine binding vary between 0.19 and 4.5 nM whereas the IC50 value for nifedipine is 2.5 nM. One of the compounds in this group (9ab) has now been selected for clinical development.
Synchrotron X-ray Reflectivity Study on the Structure of Templated Polyorganosilicate Thin Films and Their Derived Nanoporous Analogues (2001)

Comprehensive X-ray reflectivity (XR) studies were conducted to characterize the structure of thin polyalkylsilicate films made of a poly(methylsilsesquioxane-co-ethylenylsilsesquioxane) precursor containing a star-shaped poly(ε-caprolactone) as a pore generator (porogen). The films were deposited on silicon wafer substrates by spin-coating and subsequently cured at various temperatures. Such spin-on glasses have a potential application as a low-dielectric-constant material for advanced semiconductors. Because high-intensity synchrotron X-ray radiation was used, the XR data could be measured over 9 orders of magnitude in intensity, which facilitated the observation of fine structural details. A hierarchical fitting procedure for modeling the XR data is given. By evaluation of the critical angle of total reflection of the film material, which was observed at smallest angles, in particular the film electron density could be determined with a high accuracy. The films cured at 420 °C show a lower electron density as compared to those cured at 250 °C. This is explained by the fact that at the higher temperature the porogen is calcined and escapes from the films leaving behind a nanoporous structure. Film porosities could be estimated from the observed changes in the electron densities. From the very large number of high-frequency oscillations observed in the XR curves, it is concluded that the films exhibit a homogeneous, well-defined structure with small interface and surface roughness. The film thickness could be determined with an accuracy of ±1 Å. The observation of an additional low-frequency modulation of the XR curves revealed a surface skin layer with a thickness of ca. 45 Å and with a slightly increased electron density as compared to the bulk of the film.
Mätfel i provträdsvariabler och dess inverkan på precision och noggrannhet i volymskattningar (1999)

This paper deals with the assessment of a real prestressed tendon by the use of Barkhausen noise emission. The tendon was obtained from a real highway bridge after 33 years in service. Barkhausen noise is studied as a function of the stress state, and the Barkhausen noise signals received directly from the tendon on the real bridge are compared with the Barkhausen noise signals received from the tendon during loading in the laboratory. Assessment of the prestressing is based on the analysis of the effective value of the Barkhausen noise signal as well as the position in which the Barkhausen noise envelopes attain a maximum.
Genetic Gain and Inbreeding from Genomic Selection in a Simulated Commercial Breeding Program for Perennial Ryegrass (2016)

Genomic selection (GS) provides an attractive option for accelerating genetic gain in perennial ryegrass ( Lolium perenne L .) improvement given the long cycle times of most current breeding programs. The present study used simulation to investigate the level of genetic gain and inbreeding obtained from GS breeding strategies compared with traditional breeding strategies for key traits (persistency, yield, and flowering time). Base population genomes were simulated through random mating for 60,000 generations at an effective population size of 10,000. The degree of linkage disequilibrium (LD) in the resulting population was compared with that obtained from empirical studies. Initial parental varieties were simulated to match diversity of current commercial cultivars. Genomic selection was designed to fit into a company breeding program at two selection points in the breeding cycle (spaced plants and miniplot). Genomic estimated breeding values (GEBVs) for productivity traits were trained with phenotypes and genotypes from plots. Accuracy of GEBVs was 0.24 for persistency and 0.36 for yield for single plants, while for plots it was lower (0.17 and 0.19, respectively). Higher accuracy of GEBVs was obtained for flowering time (up to 0.7), partially as a result of the larger reference population size that was available from the clonal row stage. The availability of GEBVs permit a 4‐yr reduction in cycle time, which led to at least a doubling and trebling genetic gain for persistency and yield, respectively, than the traditional program. However, a higher rate of inbreeding per cycle among varieties was also observed for the GS strategy.
Low Power and High Gain Double-Balanced Mixer dedicated to 77 GHz Automotive Radar Applications (2010)

International audience
Effect of hydrostatic pressure on local polymer dynamics in poly(propylene oxide) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of hydrostatic pressure on local polymer dynamics in poly(propylene oxide)Benny D. Freeman, Liliane Bokobza, Philippe Sergot, Lucien Monnerie, and F. C. De SchryverCite this: Macromolecules 1990, 23, 9, 2566–2573Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ma00211a026https://doi.org/10.1021/ma00211a026research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts