gebhart/patrepeval huggingface dataset:
Physics on development of open-air atmospheric pressure thin film fabrication technique using mist droplets: Control of precursor flow (2014)

Mist CVD, which is one of the functional thin-film fabrication methods carried out under open-air atmospheric pressure, has been developed for advanced control of precursor streams in order to achieve the fabrication of uniform thin films. In order to obtain a uniform stream of flow including mist droplets, collisional mixing has been considered, and a fine channel (FC) nozzle has been developed using this technology. In the FC, mist droplets are affected by the lift forces toward the direction of the substrate, the gas temperature of the entire area reaches a constant, and owing to the Leidenfrost effect, the evaporation time of a mist droplet is remarkably long as several hundred milliseconds and the migration of a mist droplet extends to a distance of several hundred millimeters. From these characteristic phenomena in the FC, the formation of uniform thin films on the entire surface has been achieved using the FC-type mist (FCM-) CVD system.
Neurotrophin system activation in pleural effusions (2010)

Neurotrophins (NTs) expression was assessed in malignant and non-malignant pleural effusions (inflammatory exudates and transudates). Enzyme-linked immunosorbent assay, in malignant exudates from small and non-small cell lung cancer (SCLC and NSCLC), detected nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), and their levels are higher as compared with inflammatory and transudative effusions. By immunoblots, in cultured cancer cells coming from malignant pleural effusions, NTs and low- and high-affinity NT receptors were detected in a percentage of SCLC and NSCLC. Proliferation assay demonstrated that BDNF significantly increased cancer cell proliferation in vitro, on the contrary, NT-3 reduced cancer cell growth rate and NGF did not modify cell growth. Moreover, NGF protects cells from death during starvation. These effects are reverted by the addition of NT receptor antagonists. Cultured cancer cells injected into the lung of immunodeficient mice generate lung tumors expressing NTs and NT receptors. These findings suggest that NTs may be able to modulate cancer cell behavior and their growth.
Occurrence of ovarian cancer 13 years after a total hysterectomy and bilateral salpingo-oophorectomy for endometriosis: A case report and literature review (2014)

This article reports a rare case of cancer derived from ovarian remnant tissue. A 52-year-old woman, with a history of a total hysterectomy and bilateral salpingo-oophorectomy for uterine myomas and endometriosis 13 years ago, presented with a pelvic mass accompanied by high serum levels of CA125 and CA199. Exploratory laparotomy and pathology report revealed an ovarian serous tumor with low malignant potential. Cancer derived from ovarian remnant tissue is extremely rare. However, a malignancy may still originate from the ovarian remnant. Ovarian remnant syndrome after oophorectomy and its possibility of malignancy, especially in case of endometriosis, should not be neglected.
28. TWO-PHASE TREATMENT WITH A CEMENT SPACER FOR SEPTIC NONUNION OF THE LEG: 27 CASES (2011)

Purpose of the study: There are several goals for the treatment of septic nonunion of the leg: control the infection, achieve healing, preserve function. The purpose of this work was to report the results obtained with a two-phase technique using a cement spacer. Material and method: From 1994 to 2007, 27 patients were treated for a septic nonunion of the tibia (19 proven, 8 suspected). There were 22 women and 5 men, mean age 39 years (range 16–66). The first phase of the surgical technique involved “cancerological” cleaning and insertion of an antibiotic cement spacer. Osteosynthesis was performed if necessary. Antibiotics were adapted to sample results. The second phase involved an autologous bone graft with osteosynthesis after biological markers had returned to normal and an antibiotic window. Antibiotics were then discontinued if samples were negative. Patients were reviewed with physical examination, radiology, and laboratory tests at one year. Results: Mean follow-up was 4 years (range 1–11). At the first phase, mean bone defect after cleaning was 5 cm (range 3–8); osteosynthesis procedures were required for 22 patients (81.5%), mainly with plate fixation. Mean time to the second phase was 4 months (range 1.5–22). At the second phase, bone loss was filled with isolated bone fragments (44%) or associated with a tricortical graft (52%) or a plate nail combination (37%). Bacteriological samples were negative for 25 patients after the second phase. Six patients required surgical revision for recurrent aseptic non-union (22%). Discussion: All patients healed at mean one year with a tolerable misalignment in 37%. At last follow-up there were no cases of infection. Nineteen patients had residual stiffness of the ankle or knee but 80% had resumed their sports activities and 85% their occupational activities. Conclusion: A two-phase surgical treatment of septic non-union of the leg is effective. We were able o achieve cure of the infection in all patients with per primam healing in 78% in addition to an acceptable functional outcome. The spacer offers the advantage of preparing a bed for the graft and preserving autonomy between the two phases.
High incidence of occult thyroid disease among general medical ward patients. (1995)

The objective of this study was to prospectively determine the efficacy of the results of routine testing of thyroid functions in patients admitted to a general medical ward. Blood for thyroid function tests was drawn on admission as part of the laboratory screening panel from 270 consecutive patients. Fifty-one were excluded due to recognition of thyroid-related problems by the clinical staff. 138 patients (63%) had normal free thyroxin (FT4) levels, one patient had hyperthyroidism, 15 patients (6.8%) had laboratory primary hypothyroidism and 65 patients (29.6%) had equivocal results (FT4 < 0.9 ng/dL and TSH < 5.0 mmu/L). In eight out of 31 patients in the latter group, the thyroid releasing hormone (TRH) test revealed primary or secondary hypothyroidism. A total of 55 patients (25.1%) expired within one year. The mortality rate was significantly higher among the low FT4 patients (p < 0.01), and was independent of age and sex. We conclude that inclusion of FT4 in a laboratory screening panel will reveal a large patient population with abnormal results. However, establishing the diagnosis requires additional tests. Therefore, screening for occult hypothyroidism among a select population, not the acutely sick, populations may be more efficient.
Effective Single-SPAD Implementation of Quantum Key Distribution (2019)

We propose a novel implementation of BB84 protocol for QKD, based on the use of a Faraday rotator variable over four levels and a single SPAD. The feasibility of this solution has been experimentally verified.
Low-resistive and homogenous NiPt-silicide formation using ultra-low temperature annealing with microwave system for 22nm-node CMOS and beyond (2010)

A novel NiPt-silicide formation using microwave annealing (MWA) is proposed, and superior properties of NiPt silicide in ultra-shallow junction (USJ) are demonstrated for the first time. MWA is suitable for the thin NiPtSi formation with its stable and ultra-low temperature (less than 250 °C) heating. The anomalous Ni diffusion during the NiPtSi formation is considered to be suppressed because MW system heats Si substrates selectively. As a result, low-resistive and homogeneous NiPtSi can be formed, and the increase of the junction leakage current due to the abnormal NiPt-silicide growth is successfully suppressed in USJ. This superior technique is quite promising for achieving 22nm-node CMOS and beyond.
Multi-band OFDM transmission and receiver limitations at 100 Gbps with sub-band optical switching (2014)

International audience
Personalized therapy for metastatic colorectal cancer: A closer possibility? (2007)

4131 Background: Colorectal cancer (CRC) is the second leading cause of cancer related death in the Western world, and survival rate is closely associated with the development of metastases. Personalized targeted therapies promise to have a dramatic impact on the treatment of cancer over the next decade. The molecular fingerprint of a patient’s tumor is the basis for specific targeted therapy. Most often, we are not measuring what we are treating. If we choose therapy based on the primary tumor, but we are treating the metastasis, we are likely giving the wrong therapy if the two microenvironments are not equivalent. In this study we employed reverse phase protein microarrays (RPPA) to compare the protein kinases signal pathway derangements in the primary CRC and in its synchronous liver metastasis. Methods: Pure cell populations of 34 cases of patient-matched CRC and hepatic metastases (collected at the same surgical time) were isolated through laser capture microdissection and then lysed. The lysed cells were evaluated using RPPA technology that allowed us to analyze the activation status of 80 different kinases. Data analysis was performed using commercially available software. Results: Of the 80 kinases only 20 endpoints were significantly (p&lt; 0.05) altered between the two populations. These endpoints were contained within just a few signaling pathways, including the PI3K-AKT prosurvival pathway and the c-kit/PDGFr/c-abl growth factor pathway. We noted a significant increase in phosphorylation of AKT along with a decrease in phosphorylation of PTEN in the liver metastasis compared to the matched primary tumors. This is in keeping with what is known about AKT since phosphorylation of PTEN serves to destabilize the protein, which serves as a natural upstream suppressor of AKT kinase. Conclusions: Specific cell signaling pathways, such as the PI3K-AKT and the c-kit/PDGFr/c-abl growth factor signaling pathway, are significantly altered and activated in hepatic metastasis compared to the primary colorectal site. Since the data reveals elevation in kinase activity increases on a pathway-wide level, a rational hypothesis can be developed whereby combinations of drugs such as an AKT- mTOR inhibitor and/or Gleevec may be an effective and novel therapeutic strategy for the treatment of metastatic CRC. No significant financial relationships to disclose.
AB012. The effects of monocular deprivation do not accumulate across days in adults with normal vision (2019)

Background: We investigate whether changes in visual plasticity induced by monocular deprivation can be maintained across multiple days. It has been known that monocular deprivation strengthens the deprived eye in adults with normal vision for a short period of time (30–60 minutes). This has been shown through a variety of visual tasks such as binocular combination and rivalry.
GOVE’S GREATEST CONTRIBUTION? (2021)

By taking sides in the long-running ‘Reading Wars’ and terminating the existing model of early reading instruction with extreme prejudice, Michael Gove took one of the boldest, most contentious, unpopular and far-reaching decisions of his tenure as Education Secretary. This paper investigates the history, the battle lines, the weaponry and, if, indeed, he won the war, whether it resulted in more children in England being able to read. The results suggest that this, rather than his changes to curriculum and assessment, may be his greatest legacy.
GENERATION OF NEW SPATIAL AND TEMPORAL COHERENT LIGHT STATES USING III-V SEMICONDUCTOR METASURFACE BASED LASER TECHNOLOGY: VORTEX, CONTINUUM, DUAL FREQUENCY FOR THz (2017)

International audience
A rapidly deployable individualized system for augmenting ventilator capacity (2020)

Strategies to split ventilators to support multiple patients requiring ventilatory support have been proposed and used in emergency cases in which shortages of ventilators cannot otherwise be remedied by production or procurement strategies. However, the current approaches to ventilator sharing lack the ability to individualize ventilation to each patient, measure pulmonary mechanics, and accommodate rebalancing of the airflow when one patient improves or deteriorates, posing safety concerns to patients. Potential cross-contamination, lack of alarms, insufficient monitoring, and inability to adapt to sudden changes in patient status have prevented widespread acceptance of ventilator sharing. We have developed an individualized system for augmenting ventilator efficacy (iSAVE) as a rapidly deployable platform that uses a single ventilator to simultaneously and more safely support two individuals. The iSAVE enables individual-specific volume and pressure control and the rebalancing of ventilation in response to improvement or deterioration in an individual's respiratory status. The iSAVE incorporates mechanisms to measure pulmonary mechanics, mitigate cross-contamination and backflow, and accommodate sudden flow changes due to individual interdependencies within the respiratory circuit. We demonstrate these capacities through validation using closed- and open-circuit ventilators on linear test lungs. We show that the iSAVE can temporarily ventilate two pigs on one ventilator as efficaciously as each pig on its own ventilator. By leveraging off-the-shelf medical components, the iSAVE could rapidly expand the ventilation capacity of health care facilities during emergency situations such as pandemics.
Silica Hollow Core Antiresonant Fiber for Harsh Environment Mid-IR Sensing Applications (2019)

International audience
RAD001 Exerts Anti-Tumor Activity in Waldenstrom Macroglobulinemia. (2009)

Abstract Abstract 3732 Poster Board III-668 Background Waldenstrom Macroglobulinema (WM) is an incurable B-cell disorder characterized by the presence of IgM monoclonal gammopathy and bone marrow infiltration of lymphoplasmacytic cells. Apart from promising advances in therapeutic strategy, response rates and treatment-free survival remain inconsistent across prescribed regimens. As we have previously shown, the PI3K/Akt pathway actively mediates tumor growth, survival, migration, and cell cycle within primary WM cells. An active target of this pathway includes the downstream mammalian target of rapamycin (mTOR). By inhibiting the mTOR pathway with RAD001 (Afinitor™, Novartis Pharmaceuticals), we hoped to constructively regulate aforementioned cellular function, and also understand from a preclinical perspective its specificity of action in our microenvironmental models, both alone and the presence of monoclonal antibody against CD20 and proteasome inhibitor. Methods WM cell lines (BCWM1) and IgM secreting cell lines MEC1 and RL were used. Bone marrow stromal cells (BMSC) were obtained from patients with WM. Peripheral blood mononuclear cells were harvested from healthy donors. Agents tested included RAD001, Rituximab and Bortezomib. Cytotoxicity, DNA synthesis, and cell cycle were measured using MTT assay, [3H]-thymidine uptake, and flow cytometry/PI staining, respectively. Antibody-dependent cellular cytoxicity (ADCC), transwell, and Matrigel assays were preformed to measure cell lysis, SDF-1 chemotaxis-induced migration, and angiogenesis, respectively. Adhesion to fibronectin has been evaluated with WM cells and BMSC in the presence of RAD001, with and without Bortezomib. Results RAD001 induced cytotoxicity and inhibition of DNA synthesis with an IC50 of 1-10 nM in BCWM1 cells at 48 hours. Similar effects were seen in IgM cell lines with an effective dose of 0.1-1 nM. In contrast, at IC50 treatment level donor cells displayed no significant cytotoxicity (&gt;85% survival). Cell cycle analysis showed corresponding G1 arrest, and angiogenesis was also inhibited. RAD001, Bortezomib, and Rituxan combinations showed synergistic cytotoxicity, which was attenuated when WM cells were co-cultured with BMSC. Migration of BCWM1 and adhesion of BCWM1 to BMSC was reduced under presence of RAD001. Conclusions These functional assays therefore show that RAD001 has significant and synergistic antitumor activity in WM which will inform the design of future clinical trials. Disclosures: Ghobrial: Millennium: Honoraria, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Speakers Bureau; Novartis: Honoraria, Speakers Bureau.
Synthesis and characterization of site‐specific biotinylated probes for the motilin receptor* (1994)

The solid-phase synthesis of two porcine motilin derivatives, specifically biotinylated on the side chain of Lys20, was accomplished by preactivation of the protected amino acids N alpha-(9-fluorenylmethoxycarbonyl)-N epsilon-biotinyl-L-lysine and N alpha-(9-fluorenylmethoxycarbonyl)-N epsilon-[N-(biotinyl)-6-aminohexanoyl]-L-lysine with BOP/HOBt/DIEA (1:1:2.5) followed by coupling to the support-bound peptide substrate. The biotin moiety was stable to TFA cleavage and repetitive cycles of acylation, as evidenced by the high level of purity (> 80%) of the crude peptides. This direct synthetic approach complements existing orthogonal protection strategies for the site-specific biotinylation of peptides. The derivatized peptides were purified by RP-HPLC and characterized by mass spectral and amino acid analysis. In binding studies using a rabbit antral smooth muscle homogenate, both [Leu13, Lys20 (N epsilon-biotinyl)]porcine motilin (3) and [Leu13, Lys20 (N epsilon-[N-(biotinyl)-6-aminohexanoyl])]porcine motilin (4) possessed nearly equal affinities for the motilin receptor (IC50 = 0.89 and 1.2 nM, respectively) as native porcine motilin (1) (IC50 = 0.76 nM). The biotinylated peptides were also highly potent in tissue bath assays employing rabbit duodenal smooth muscle segments. In contrast, commercially available [N alpha-biotinylPhe1]porcine motilin (5) had markedly lower affinity in the binding assay (IC50 = 30 nM). The relative bioactivities of these receptor probes are in accord with previous synthetic studies on motilin which demonstrated the importance of the amino-terminal segment in the high affinity interaction between the peptide and its receptor. Analog 3 retained high affinity for the motilin receptor in the presence of avidin. Therefore, this peptide is expected to be a valuable tool for the isolation and identification of motilin receptors.
A Prospective, Nonrandomized, Multicenter Evaluation of Extreme Lateral Interbody Fusion for the Treatment of Adult Degenerative Scoliosis (2010)

The morbidity in adult scoliosis surgery is minimized with less invasive techniques. The rate of major complications in this study (12.1%) compares favorably to that reported from other studies of surgery for degenerative deformity.
Semiclassical calculation of the diffusion constant for the Λ system momentum (1995)

We present a one-dimensional, semiclassical calculation of the momentum diffusion constant for a stationary \ensuremath{\Lambda} atom. We show that if the difference detuning between the driving fields is zero, the diffusion vanishes, and we interpret this behavior in terms of the atom-field eigenstates. We present explicit solutions to the equations of motion in the special case where one of the driving fields vanishes and compare them to the case of a two-level atom at a field node. Finally, we examine the correspondence between the semiclassical and quantum-mechanical analyses at zero difference detuning and we show a correspondence between the semiclassical and quantum-mechanical dark states when the driving fields are superpositions of plane waves with the same magnitude of wave vector.
In Vitro Induction of Eryptosis by Uremic Toxins and Inflammation Mediators in Healthy Red Blood Cells (2022)

Eryptosis is the stress-induced RBC (red blood cell) death mechanism. It is known that eryptosis is largely influenced by plasma and blood composition, and that it is accelerated in patients affected by chronic kidney disease (CKD). The aim of this study is to evaluate the eryptosis rate in healthy RBCs treated with different concentration of IL-6, IL-1β, urea and p-cresol, comparable to plasmatic level of CKD patients, at different time points. We exposed healthy RBCs to increasing concentrations of IL-6, IL-1β, urea and p-cresol. Morphological markers of eryptosis (cell membrane scrambling, cell shrinkage and PS exposure at RBC surface) were evaluated by flow cytometric analyses. The cytotoxic effect of cytokines and uremic toxins were analyzed in vitro on healthy RBCs at 4, 8 and 24 h. Morphology of treated RBCs was dramatically deranged, and the average cell volume was significantly higher in RBCs exposed to higher concentration of all molecules (all, p < 0.001). Furthermore, healthy RBCs incubated with each molecules demonstrated a significant increase in eryptosis. Cytofluorimetric analysis of eryptosis highlighted significantly higher cell death rate in RBCs incubated with a higher concentration of both cytokines compared with RBCs incubated with a lower concentration (all, p < 0.05). In conclusion, our data show that cytokines and uremic toxins have a harmful effect on RBCs viability and trigger eryptosis. Further studies are necessary to validate these results in vivo and to associate abnormal eryptosis with cytokine levels in CKD patients. The eryptosis pathway could, moreover, become a new promising target for anemia management in CKD patients.
Novel Diamidines with Activity against Babesia divergens In Vitro and Babesia microti In Vivo (2011)

Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine compounds against the Babesia divergens strains 1903B and 4201 were investigated. The most potent compound, a diphenyl furan, had a 50% inhibitory concentration (IC(50)) of 1.5 ng/ml. In a murine model, several test compounds were effective enough to cure mice infected with Babesia microti at a dose of 12.5 and/or 25 mg/kg of body weight given by the subcutaneous route for 4 days. The best antibabesial properties were exhibited by terphenyls, benzimidazoles, diphenyl furans, pentamidine, and pentamidine analogues.
An Accurate Nonlinear Noise Insensitive OSNR Monitor (2016)

We propose a new design for pilot based OSNR monitor with XPM noise exclusion at the receiver side. High accuracy and low nonlinear sensitivity (&lt;0.5dB error) are proved by 1Tb/s superchannel transmission experiments.
Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle (2004)

Pressure overload, ischemia, and neurohormonal factors, such as Ang II or alpha1-adrenergic stimuli, induce myocardial expression of CCN1, a potent proangiogenic factor, supporting the notion that CCN1 may play an important role in the adaptation of the heart to cardiovascular stress.