gebhart/patrepeval huggingface dataset:
Providing assurances in a multimedia interactive environment (1995)

Article Free Access Share on Providing assurances in a multimedia interactive environment Authors: Dorée Duncan Seligmann Multimedia Communication, Research Department, AT&T Bell Laboratories 4F-605, 101 Crawfords Corner Road, Holmdel, New Jersey Multimedia Communication, Research Department, AT&T Bell Laboratories 4F-605, 101 Crawfords Corner Road, Holmdel, New JerseyView Profile , Rebecca T. Mercuri School of Engineering and Applied Science, University of Pennsylvania, P.O. Box 1166, Philadelphia, Pennsylvania School of Engineering and Applied Science, University of Pennsylvania, P.O. Box 1166, Philadelphia, PennsylvaniaView Profile , John T. Edmark Multimedia Communication, Research Department, AT&T Bell Laboratories 4F-605, 101 Crawfords Corner Road, Holmdel, New Jersey Multimedia Communication, Research Department, AT&T Bell Laboratories 4F-605, 101 Crawfords Corner Road, Holmdel, New JerseyView Profile Authors Info & Claims CHI '95: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsMay 1995 Pages 250–256https://doi.org/10.1145/223904.223936Published:01 May 1995Publication History 10citation365DownloadsMetricsTotal Citations10Total Downloads365Last 12 Months18Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Muscle Fascia Changes in Patients with Occipital Neuralgia, Headache, or Migraine (2020)

In an ongoing effort to understand the pathogenesis of occipital neuralgia/headache/migraine, it is critical to describe the anatomical/tissue changes encountered during surgery. Greater occipital nerve anatomical studies mainly focus on the greater occipital nerve course through muscle/fascial planes and interaction with the occipital vessels. However, structural soft-tissue changes have not been described in detail. Anecdotally, trapezius fascia is thickened at the greater occipital nerve trigger site. This study further investigates this observation. Patients undergoing greater occipital nerve decompression surgery were enrolled prospectively in this observational study (n = 92). Tissue changes were recorded intraoperatively. The resulting data were examined. Trapezius fascia was more than 3 mm thick and appeared fibrotic in 86 patients (94 percent), whereas semispinalis muscle appeared normal in all subjects. The greater occipital nerve was macroscopically abnormal, defined as edematous, flattened, and discolored in 29 cases (32 percent). The occipital artery interacted significantly with the greater occipital nerve in 88 percent of cases. The authors conclude that the tissue structure is abnormal in patients undergoing greater occipital nerve decompression surgery. This is the first study that describes the prevalence of thickened and fibrotic appearing trapezius fascia at the occipital trigger site, a phenomenon encountered in the vast majority of patients (94 percent). This structural anomaly has a resemblance to thickened fascial tissues seen in other nerve compression syndromes, and could be related to microtrauma/overuse or actual trauma in the head and neck region.
Noninvasive switchable acousto-optic taps for optical fiber (1990)

Two novel tap designs are demonstrated based on phase-matched coupling from the fundamental mode of a fiber to a higher-order core-guided or cladding-guided mode through the acoustooptic effect. The acoustic waves are coupled to the fiber using a Hertzian (deformed surface-to-surface) contact with a grooved transducer substrate. The first tap consists of a two-mode fiber coupler in conjunction with a microbend tap. The coupler converts approximately 5% of the fundamental mode power to the second-order mode. At the microbend tap, the higher-order mode is preferentially radiated from the fiber. The second tap uses a similar mode-coupling mechanism to convert a fraction of the fundamental mode power into a cladding-guided mode in a single-mode fiber.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients (2017)

To our knowledge, this is the first study to present a possible association between FTO gene variants and the genetic etiology of sALS. In addition, the next-generation sequencing-based genomics approach coupled with the two-step validation strategy described herein has the potential to be applied to other types of human complex genetic disorders in order to identify variants of clinical significance.
Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance (2011)

Understanding how proteins function at the atomic level relies in part on a detailed characterization of their dynamics. Ubiquitin, a small single-domain protein, displays rich dynamic properties over a wide range of time scales. In particular, several regions of ubiquitin show the signature of chemical exchange, including the hydrophobic patch and the β4-α2 loop, which are both involved in many interactions. Here, we use multiple-quantum relaxation techniques to identify the extent of chemical exchange in ubiquitin. We employ our recently developed heteronuclear double resonance method to determine the time scales of motions that give rise to chemical exchange. Dispersion profiles are obtained for the backbone NH(N) pairs of several residues in the hydrophobic patch and the β4-α2 loop, as well as the C-terminus of helix α1. We show that a single time scale (ca. 50 μs) can be used to fit the data for most residues. Potential mechanisms for the propagation of motions and the possible extent of correlation of these motions are discussed.
Small molecule binders recognize DNA microstructural variations via an induced fit mechanism (2019)

Regulation of gene-expression by specific targeting of protein-nucleic acid interactions has been a long-standing goal in medicinal chemistry. Transcription factors are considered "undruggable" because they lack binding sites well suited for binding small-molecules. In order to overcome this obstacle, we are interested in designing small molecules that bind to the corresponding promoter sequences and either prevent or modulate transcription factor association via an allosteric mechanism. To achieve this, we must design small molecules that are both sequence-specific and able to target G/C base pair sites. A thorough understanding of the relationship between binding affinity and the structural aspects of the small molecule-DNA complex would greatly aid in rational design of such compounds. Here we present a comprehensive analysis of sequence-specific DNA association of a synthetic minor groove binder using long timescale molecular dynamics. We show how binding selectivity arises from a combination of structural factors. Our results provide a framework for the rational design and optimization of synthetic small molecules in order to improve site-specific targeting of DNA for therapeutic uses in the design of selective DNA binders targeting transcription regulation.
High-Assurance Avionics Multi-Domain RFID Processing System (2008)

Distributed processing of RFID information enables new RFID applications where tags, readers and processing systems belong to different administrative domains and where multiple RFDD applications are realized using a common reader and processing infrastructure. A novel distributed RFID processing architecture supporting various future eEnabled airplane applications based on RFID technology is described. In a particularly challenging application environment, RFID readers are installed on-board airplanes and connected dynamically by wireless communication with various ground system at airports and during maintenance. The airplane RFDD reader infrastructure has to be dynamically integrated with different ground systems. The security requirements caused by this temporal integration within different administrative domains and corresponding solution approaches are described.
Medusa (2012)

The ubiquity of smartphones and their on-board sensing capabilities motivates crowd-sensing, a capability that harnesses the power of crowds to collect sensor data from a large number of mobile phone users. Unlike previous work on wireless sensing, crowd-sensing poses several novel requirements: support for humans-in-the-loop to trigger sensing actions or review results, the need for incentives, as well as privacy and security. Beyond existing crowd-sourcing systems, crowd-sensing exploits sensing and processing capabilities of mobile devices. In this paper, we design and implement Medusa, a novel programming framework for crowd-sensing that satisfies these requirements. Medusa provides high-level abstractions for specifying the steps required to complete a crowd-sensing task, and employs a distributed runtime system that coordinates the execution of these tasks between smartphones and a cluster on the cloud. We have implemented ten crowd-sensing tasks on a prototype of Medusa. We find that Medusa task descriptions are two orders of magnitude smaller than standalone systems required to implement those crowd-sensing tasks, and the runtime has low overhead and is robust to dynamics and resource attacks.
The role of Foxp3+ T cells in long‐term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice (2006)

From these data we concluded (i) that the mechanisms underlying peripheral tolerance are linked to the conformation of the antigen, (ii) that mucosal tolerance is mediated by separate regulatory cell subsets, and (iii) that the long-term efficacy of immunosuppression is associated with the presence of Foxp3+ T cells.
Privacy-Preserving Outlier Detection Through Random Nonlinear Data Distortion (2010)

Consider a scenario in which the data owner has some private or sensitive data and wants a data miner to access them for studying important patterns without revealing the sensitive information. Privacy-preserving data mining aims to solve this problem by randomly transforming the data prior to their release to the data miners. Previous works only considered the case of linear data perturbations--additive, multiplicative, or a combination of both--for studying the usefulness of the perturbed output. In this paper, we discuss nonlinear data distortion using potentially nonlinear random data transformation and show how it can be useful for privacy-preserving anomaly detection from sensitive data sets. We develop bounds on the expected accuracy of the nonlinear distortion and also quantify privacy by using standard definitions. The highlight of this approach is to allow a user to control the amount of privacy by varying the degree of nonlinearity. We show how our general transformation can be used for anomaly detection in practice for two specific problem instances: a linear model and a popular nonlinear model using the sigmoid function. We also analyze the proposed nonlinear transformation in full generality and then show that, for specific cases, it is distance preserving. A main contribution of this paper is the discussion between the invertibility of a transformation and privacy preservation and the application of these techniques to outlier detection. The experiments conducted on real-life data sets demonstrate the effectiveness of the approach.
Spectroscopic Consequences of a Mixed Valence Excited State:  Quantitative Treatment of a Dihydrazine Diradical Dication (2003)

A model for the quantitative treatment of molecular systems possessing mixed valence excited states is introduced and used to explain observed spectroscopic consequences. The specific example studied in this paper is 1,4-bis(2-tert-butyl-2,3-diazabicyclo[2.2.2]oct-3-yl)-2,3,5,6-tetramethylbenzene-1,4-diyl dication. The lowest energy excited state of this molecule arises from a transition from the ground state where one positive charge is associated with each of the hydrazine units, to an excited state where both charges are associated with one of the hydrazine units, that is, a Hy-to-Hy charge transfer. The resulting excited state is a Class II mixed valence molecule. The electronic emission and absorption spectra, and resonance Raman spectra, of this molecule are reported. The lowest energy absorption band is asymmetric with a weak low-energy shoulder and an intense higher energy peak. Emission is observed at low temperature. The details of the absorption and emission spectra are calculated for the coupled surfaces by using the time-dependent theory of spectroscopy. The calculations are carried out in the diabatic basis, but the nuclear kinetic energy is explicitly included and the calculations are exact quantum calculations of the model Hamiltonian. Because the transition involves the transfer of an electron from the hydrazine on one side of the molecule to the hydrazine on the other side and vice versa, the two transitions are antiparallel and the transition dipole moments have opposite signs. Upon transformation to the adiabatic basis, the dipole moment for the transition to the highest energy adiabatic surface is nonzero, but that for the transition to the lowest surface changes sign at the origin. The energy separation between the two components of the absorption spectrum is twice the coupling between the diabatic basis states. The bandwidths of the electronic spectra are caused by progressions in totally symmetric modes as well as progressions in the modes along the coupled coordinate. The totally symmetric modes are modeled as displaced harmonic oscillators; the frequencies and displacements are determined from resonance Raman spectra. The absorption, emission, and Raman spectra are fit simultaneously with one parameter set. The coupling in the excited electronic state H(ab)(ex) is 2000 cm(-1). Excited-state mixed valence is expected to be an important contributor to the electronic spectra of many organic and inorganic compounds. The energy separations and relative intensities enable the excited-state properties to be calculated as shown in this paper, and the spectra provide new information for probing and understanding coupling in mixed valence systems.
Abstract 16538: Salt Loading in the Presesnce of Baroreflex Failure Predisposes to Pulmonary Edema in Spontaneously Hypertensive Rat (2013)

BACKGROUND: Patients with heart failure and preserved ejection fraction (HFpEF) are supersensitive to volume overload, and thus pulmonary edema. These patients have a high prevalence of severe arteriosclerosis, baroreflex dysfunction and salt-sensitive hypertension. Baroreflex is by definition regulates arterial pressure (AP), and also is a very powerful regulator of stressed blood volume. We recently demonstrated that deactivating the baroreflex results in striking volume intolerance. In the present study, we examined how baroreflex failure induced by sino-aortic denervation (SAD) and salt loading affect daily fluctuations of left atrial pressure (LAP) in hypertensive model rats. Methods: We allocated freely moving 14 weeks old spontaneously hypertensive rats (SHR) (n=16) into 2 groups, SAD or sham operation (Sham). In the following week, we implanted a telemetry system to measure AP and LAP. One week after the second surgery, 2 groups were subjected to either normal (N-salt, 0.5% NaCl) or high salt diet (H-salt, 8% NaCl). We recorded AP and LAP a week after the initiation of N-salt or H-salt diet and generated histograms of LAP distribution for 24 hours. Results: SAD did not increase AP (Sham/N-salt:150.6±7.6 vs. SAD/N-salt: 146.4±1.9 mmHg, NS, n=4 for each). However, H-salt increased AP both in Sham and SAD . In LAP histograms, SAD/H-salt increased mean LAP (SAD/H-salt:14.9±2.6 vs. Sham/N-salt: 11.4±1.6 mmHg, p CONCLUSIONS: SAD with high salt intake strikingly increases LAP variations through the volume intolerance and frequently causes high LAP (20% of 24 hours) in SHR. These results strongly suggest that baroreflex failure would play a crucial role in the pathogenesis of pulmonary edema in patients with HFpEF.
Antenna Impedance Variation Compensation by Exploiting a Digital Doherty Power Amplifier Architecture (2015)

This paper presents a comprehensive theoretical study on Doherty power amplifiers (PAs) under antenna impedance mismatch. It is demonstrated for the first time that by varying the relative gain and phase of the carrier and peaking amplifiers, the PA performance degradation caused by the antenna impedance mismatch can be largely compensated. Such a compensation effect is discussed extensively for different antenna impedance conditions. Four types of Doherty PAs, i.e., three digital Doherty PAs with different degrees of flexibility and the classical analog Doherty PA, are covered in the complete theoretical analysis. To intuitively show the proposed concept, this paper presents numerical simulation results based on the theoretical analysis. In addition, measurement results on a fully integrated digital Doherty PA implemented in 65-nm bulk CMOS are demonstrated to verify our theoretical study.
Fast Electrical Control of a Quantum Dot Strongly Coupled to a Photonic-Crystal Cavity (2010)

The resonance frequency of an InAs quantum dot strongly coupled to a GaAs photonic-crystal cavity was electrically controlled via the quadratic quantum confined Stark effect. Stark shifts up to 0.3 meV were achieved using a lateral Schottky electrode that created a local depletion region at the location of the quantum dot. We report switching of a probe laser coherently coupled to the cavity up to speeds as high as 150 MHz, limited by the RC constant of the transmission line. The coupling strength g and the magnitude of the Stark shift with electric field were investigated while coherently probing the system.
AAGBI safe vascular access guidelines II (2016)

The new AAGBI safe vascular access guidelines include much well-researched and valuable information for practicing clinicians 1. Unfortunately, they also contain a recommendation that agents with pH > 9 or < 5 should be administered through central venous access devices, contrary to the 2016 Infusion Therapy Standards of Practice 2. There is no evidence from any human outcome study that support the recommendation. Moreover, numerous in-vitro and in-vivo studies have indicated the exact opposite, namely that low pH agents such as vancomycin can be administered safely via peripheral venous access 3, 4. Gorski's thorough review of research published since 1943 confirms that pH has never been implicated in the pathogenesis of infusion thrombophlebitis and affirms that pH ought not to be an indication for central venous access 5. Peripherally inserted central catheters carry a 5.2% risk of symptomatic deep vein thrombosis and pulmonary embolism and a 1–3% risk of catheter-associated bloodstream infection 6. Any recommendation selecting these potentially life-threatening devices over much safer modes of peripheral access requires firm evidential support, which does not exist. Could I respectfully ask the AAGBI Working Party to consider withdrawing this recommendation?
Author Correction: Liquid crystal elastomer coatings with programmed response of surface profile (2018)

The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article.
Dietary phosphate-dependent growth is not mediated by changes in plasma phosphate concentration. (2001)

The present study was undertaken in order to assess the role of dietary phosphate in growth. A diet deficient in phosphate led to a suppression of growth in juvenile rats. The phenomenon is similar to that described for diets deficient in other essential single components such as Mg, Zn or K. However, unlike the other constituents, dietary phosphate restriction affected the growth rate much more than it altered the serum phosphate concentration; addition of phosphate to the drinking water of rats fed a low-phosphate diet restored the growth rate without a concomitant change in serum phosphate concentration. The suppression of growth rate by the deletion of phosphate was associated with a delayed decrease in food intake. This finding implies that the variation in appetite was secondary to the change in growth. The increase in body weight following phosphate supplementation was associated with a concomitant increment in food intake. The phosphate-dependent growth was, however, evident also in rats that were pair-fed with those that were not supplied with phosphate. It is concluded that dietary phosphate-dependent growth is not mediated by changes in phosphate concentrations in the extracellular fluid. It is plausible that signals arising from receptors for phosphate in the digestive system constitute part of the growth control apparatus in rats.
Assessment of gene flow using tetraploid genotypes of perennial ryegrass ( Lolium perenne L.) (2004)

Ryegrass species are among the most important species in sown pastures, turf settings, and weed populations worldwide. Perennial ryegrass ( Lolium perenne L.) is an outcrossing, wind-pollinated grass. Recent research has demonstrated the feasibility of developing transgenic perennial ryegrass varieties. In order to model the consequences of gene flow from transgenic grass genotypes in a field situation, the model non-transgenic trait of fertility among autotetraploid genotypes was chosen. Gene flow over distance and direction from a donor plot to surrounding sexually compatible recipient plants was studied. Reproductive isolation was achieved through the fertility barrier that arises between tetraploid and diploid ryegrass genotypes, despite the presence of diploid plants in a meadow situation. Fertility was used as an indication of effective gene flow over distance and direction. Measures of the fertility of recipient plants included total seed production (TSP), floret site utilisation (FSU), and relative fertility of recipient plants as a percentage of those within the donor plot (RF%). A leptokurtic distribution for gene flow was identified, with differences in the rate of decline over distance depending on direction. Simple sequence repeat (SSR) polymorphism was used to identify the paternity of progeny plants. The proportional representation of parents among the progeny was not significantly different from that expected due to the numerical representation of the different donor parent genotypes. The results of this research will have important implications for risk analysis prior to the field release of transgenic ryegrasses, fescues, and other pasture grass species, and for seed production in terms of cultivar purity and optimum isolation distance.
Modeling Mechanical Properties of Segmented Polyurethanes (2009)

No AccessNano- and Micromechanics of Polymer Blends and CompositesMay 2009Modeling Mechanical Properties of Segmented PolyurethanesV. V. Ginzburg, J. Bicerano, C. P. Christenson, A. K. Schrock, A. Z. PatashinskiV. V. Ginzburg, J. Bicerano, C. P. Christenson, A. K. Schrock, A. Z. Patashinskihttps://doi.org/10.3139/9783446430129.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2009Pages: 59-89Print ISBN: 978-3-446-41323-8eISBN: 978-3-446-43012-9 Copyright & Permissions© 2009 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...