gebhart/patrepeval huggingface dataset:
Thermomechanical Analysis and Package-Level Optimization of Mechanically Flexible Interconnects for Interposer-on- Motherboard Assembly (2018)

This paper explores different means by which the interconnect reliability is improved and interposer warpage is decreased for an interposer-to-board integration platform using mechanically flexible interconnects (MFIs). Central to this exploration is the design and distribution/orientation of the MFIs on the interposer. Using finite-element-based tool ANSYS, different MFI distributions and configurations are investigated. A radially oriented interconnect distribution in which the MFIs line up along the contours of thermal expansion/contraction is evaluated. Furthermore, a multiobjective genetic algorithm is employed to reduce max von-Mises stress in the MFIs and warpage in the interposer for each MFI distribution configuration. The impact of chip size and MFI pitch (from 400 to $1200 μm) on the mechanical integrity of the MFIs and interposer are also explored.
Enabling Technology for Safe Robot-Assisted Retinal Surgery: Early Warning for Unsafe Scleral Force (2019)

Retinal microsurgery is technically demanding and requires high surgical skill with very little room for manipulation error. During surgery the tool needs to be inserted into the eyeball while maintaining constant contact with the sclera. Any unexpected manipulation could cause extreme tool-sclera contact force (scleral force) thus damage the sclera. The introduction of robotic assistance could enhance and expand the surgeon's manipulation capabilities during surgery. However, the potential intra-operative danger from surgeon's misoperations remains difficult to detect and prevent by existing robotic systems. Therefore, we propose a method to predict imminent unsafe manipulation in robot-assisted retinal surgery and generate feedback to the surgeon via auditory substitution. The surgeon could then react to the possible unsafe events in advance. This work specifically focuses on minimizing sclera damage using a force-sensing tool calibrated to measure small scleral forces. A recurrent neural network is designed and trained to predict the force safety status up to 500 milliseconds in the future. The system is implemented using an existing "steady hand" eye robot. A vessel following manipulation task is designed and performed on a dry eye phantom to emulate the retinal surgery and to analyze the proposed method. Finally, preliminary validation experiments are performed by five users, the results of which indicate that the proposed early warning system could help to reduce the number of unsafe manipulation events.
Application of a Supercharger in a Two-Stage Boosting System for a Gasoline HCCI Engine: A Simulation Study (2011)

Recently, a number of studies have demonstrated that boosting can extend the high load limit of HCCI. This paper compares two two-stage boosting systems for a 4-cylinder, 2.0 liter engine, within the framework of a 1D engine simulation. A series two-stage boosting system wherein both high and low pressure stages are turbochargers (TCTC) is compared with another series two-stage system, where the high pressure stage from TCTC is replaced with a small supercharger (TCSC). The engine model in these configurations is operated in steady state at high load boosted HCCI points (∼ 6.5 bar BMEP) over a range of engine speeds. The comparison has been carried out by two methods: in Method I the intake pressure to the engine has been matched for both TCTC and TCSC; and in Method II, the amount of fresh charge into the engine has been matched for both systems. A detailed energy balance shows that the performance in terms of BSFC for the TCSC system is worse for Method I. However, this changes for Method II, and the TCSC system is comparable or even better than the TCTC system. This is achieved by greatly reducing the pumping losses associated with the TCTC system, while the parasitic losses of the supercharger are minimized by having to boost to lower intake pressures due to lowered back pressures in the TCSC system.
Feasibility of postoperative adjuvant chemotherapy using carboplatin plus S-1 in completely resected non-small cell lung cancer patients (2019)

Feasibility is one of the major concerns during adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. A phase II clinical trial of adjuvant chemotherapy with four courses of carboplatin (AUC 5 at day 1) and S-1 (80 mg/m<sup>2</sup>/day for 2 weeks followed by a 2-week rest) was performed to evaluate the feasibility (UMIN 9101). The primary endpoint was the completion rate and the secondary endpoints were adverse events, 2-year overall survival and disease-free rates. Thirty-five non-small cell lung cancer patients were enrolled. The adjuvant chemotherapy completion rate was 85.3% (29/34); 17/34 (50%) patients completed 4 courses without dose reduction. There were no treatment-related deaths, and Grade 3/4 adverse events included neutropenia (38.2%), leukocytopenia (14.7%), anemia (20.6%), thrombocytopenia (20.6%), anorexia (5.9%), fatigue (5.9%), and oral mucositis (2.9%). Two-year overall and disease-free survival rates were 96.3% and 53.3%, respectively. Adjuvant chemotherapy with carboplatin plus S-1 is safe and feasible.
Pallister-Hall syndrome: clinical and MR features. (2000)

A 4-month-old boy with polydactyly and bifid epiglottis was found to have a large sellar and suprasellar mass. When the diagnosis of Pallister-Hall syndrome was made, conservative management was elected. When the patient was 2 years old, the tumor had grown proportionally with the patient, and he was developing appropriately. Although rare, this entity is important to recognize not only for clinical diagnosis but also for appropriate management and genetic counseling.
Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages (2020)

Abstract The development of materials capable of varying macroscale ligand distributions can emulate an extracellular matrix (ECM) remodeling and regulate the adhesion and polarization of macrophages. In this report, negatively charged slidable nano‐ligands are assembled and then conjugated to a positively charged substrate via electrostatic interaction. The negatively charged slidable nano‐ligands are prepared by coating magnetic nanoparticles with a polymer linker and negatively charged RGD ligand. The nano‐ligand sliding is characterized under an external magnetic field, which spatiotemporally alters macroscale ligand density. To the best of knowledge, this is the first demonstration that magnetic maipulation of the macroscale ligand density inhibits inflammatory M1 phenotype but stimulates the adhesion and regenerative M2 phenotype of host macrophages. Furthermore, it is elucidated that the magnetic attraction of the slidable nano‐ligand facilitates the assembly of adhesion structures in macrophages, thereby stimulating their regenerative M2 phenotype. The design of ECM‐emulating materials that allow remote, spatiotemporal, and reversible controllability of macroscale ligand density provides an appealing strategy in the spatiotemporal regulation of immunomodulatory tissue‐regenerative responses to implants in vivo.
Least-Squares Minimization Under Constraints (2010)

Unconstrained Least-Squares minimization is a well-studied problem. For example, the Levenberg-Marquardt is extremely effective and numerous implementations are readily available. These algorithms are, however, not designed to perform least-squares minimization under hard constraints. This short report outlines two very simple approaches to doing this. The first relies on standard Lagrange multipliers. The second is inspired by inverse kinematics techniques.
<title>Immunofluorescence detection methods using microspheres</title> (1999)

Microsphere-based immunoassays were devised for compounds of agricultural and biomedical interest (e.g., digoxin, theophylline, and zearalenone). Commercially available microspheres with surface functional groups for chemical derivatization were used as solid carriers. After immobilizing the target substances, the surface of the haptenized microspheres was blocked by a protein to reduce aspecific binding. Competitive immunoassays were performed using the functionalized microspheres and antibodies labeled with horseradish peroxidase. Immunofluorescence signal amplification was achieved by enzyme-catalyzed reporter deposition (CARD). An epifluorescence microscope, a CCD camera interfaced with a computer, and microscopy image analysis software were employed for quantitative detection of fluorescent light emitted from individual microspheres. Integration of several such immunoassays and application of an optical encoding method enabled multianalyte determination. These immunoassays can also be utilized in an immunosensor array format. This immunoarray format could facilitate miniaturization and automation of multianalyte immunoassays.
Beam skirting effects on energy deposition profile in VP-SEM (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Supplementary Figures from The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity (2023)

&lt;p&gt;File containing supplemental figures and legends&lt;/p&gt;
A 60-GHz superheterodyne downconversion mixer in silicon-germanium bipolar technology (2004)

A single-balanced Gilbert mixer intended for use in a superheterodyne receiver in the 57-64-GHz ISM band has been fabricated in SiGe bipolar technology. Using an output IF in the range of 8.3-9.1 GHz, the mixer achieves a voltage conversion gain >9 dB and an upper single-sideband noise figure <13 dB, with mixer core current consumption of 3.2 mA at 2.7 V. Total test-site current consumption, including an output buffer, is 19.2 mA.
The Future of Computing: Integrating Scientific Computation on Neuromorphic Systems (2020)

Neuromorphic computing is known for its integration of algorithms and hardware elements that are inspired by the brain. Conventionally, this nontraditional method of computing is used for many neural or learning inspired applications. Unfortunately, this has resulted in the field of neuromorphic computing being relatively narrow in scope. In this paper we discuss two research areas actively trying to widen the impact of neuromorphic systems. The first is Fugu, a high-level programming interface designed to bridge the gap between general computer scientists and those who specialize in neuromorphic areas. The second aims to map classical scientific computing problems onto these frameworks through the example of random walks. This elucidates a class of scientific applications that are conducive to neuromorphic algorithms.
Sustainable Thermionic O[sup −] Emission from Stoichiometric 12CaO⋅7Al[sub 2]O[sub 3] with Nanoporous Crystal Structure (2008)

We have examined electric field-assisted thermionic emission of oxygen radical anion and electron from a stoichiometric (C12A7). Lattice framework of C12A7 is composed of subnanometer-sized cages that can accommodate extra- framework species with negative charge, such as , ions, and electrons. Absence of oxygen gas supply leads to a steady coemission of ion and electron with a ratio of . However, the oxygen gas supply markedly enhances the ion emission and suppresses the electron emission, realizing a sustainable and high-purity ion emission with a current density up to at . The ion emission accompanies a weak ion emission, which is smaller by . The pressure at the rear side controls the concentrations of ion and electron on the emission surface as well as their concentrations in the bulk, and in turn, determines their emission intensities.
Development of Replaceable Cast Steel Links for Eccentrically Braced Frames (2016)

Replaceable links for eccentrically braced steel frames (EBFs) decouple the yielding links from the floor beams to facilitate rapid repair or replacement after a seismic event. Replaceable links that are composed of rolled or built-up steel sections are, however, susceptible to the same failure modes as links in conventional EBFs. These failure modes include fracture in the base metal or welds, local buckling, and lateral-torsional buckling, all of which limit the ductility of the link and consequently, the overall ductility of the frame. An extensive numerical analysis study was completed to develop replaceable cast steel link concepts, with practical connection details, that combine the advantages of replaceable links with the geometric freedom and material properties inherent to castings. Results indicate that the unique geometry of the proposed concepts achieves a larger rotation capacity and longer low-cycle fatigue life by evenly distributing flexural yielding over the entire length of the link and minimizing stress concentrations. The replaceable cast steel links have the potential to significantly improve the performance, reliability, robustness, and resilience of EBFs.
Cyamella (a popliteal sesamoid bone) prevalence: A systematic review, meta‐analysis, and proposed classification system (2021)

The cyamella is a rare, generally asymptomatic, knee sesamoid bone located in the proximal tendon of the popliteal muscle. Only two studies have investigated cyamella presence/absence in humans, putting ossified prevalence rates at 0.57%-1.8%. We aim to (a) determine cyamella prevalence in a Korean population, (b) examine coincident development of the cyamella and fabella, and (c) perform a systematic review and meta-analysis on the cyamella in humans. Medical computed tomography scans of 106 individuals were reviewed. A systematic review and meta-analysis were performed following PRISMA guidelines. Cyamellae were found in 3/212 knees (1.4%), and presence/absence was uncorrelated to height, age, and sex. The cyamella was not found coincidentally with the fabella, although the statistical power was low. Our systematic review/meta-analysis revealed cyamellae were generally asymptomatic and ossification could occur at 14 years. Cyamellae were equally likely to be found in both sexes, knees, one or both knees, and there appeared to be no global variation in prevalence rates. Cyamellae were found in three distinct locations. There is little support for the role of intrinsic genetic and/or environmental factors in cyamella development in humans. However, the apparent phylogenetic signal in Primates suggests genetics plays a role in cyamella development. We propose a cyamella classification system based on cyamella location (Class I, popliteal sulcus; Class II, tibial condyle; Class III, fibular head) and hypothesize locations may correspond to distinct developmental pathways, and cyamella function may vary with location.
Selective A2Aadenosine receptor activation reduces ischemia-reperfusion injury in rat kidney (1999)

A2A adenosine receptors (A2A-ARs) are known modulators of renal hemodynamics and potent inhibitors of inflammation. We sought to determine whether selective activation of A2A-ARs protects kidneys from ischemia-reperfusion injury. The ester derivative of DWH-146 (DWH-146e), a selective A2A agonist, was found to be more potent and selective for A2A-ARs than the prototype compound CGS-21680. Osmotic minipumps were implanted subcutaneously to infuse into rats either vehicle or DWH-146e (0.004 microg. kg(-1). min(-1)), during and after ischemia-reperfusion injury. Following 24 and 48 h of reperfusion, the rise in serum creatinine and blood urea nitrogen for vehicle-treated rats was substantially elevated compared with DWH-146e-treated rats. Histological examination revealed widespread tubular epithelial necrosis and vascular congestion in the outer medulla of vehicle-treated compared with DWH-146e-treated animals. ZM-241385, a selective A(2A) antagonist, blocked the protective effect of DWH-146e. Delaying administration of DWH-146e until the initiation of reperfusion also decreased serum creatinine. We conclude that 1) selective A2A-AR activation by DWH-146e reduces ischemia-reperfusion injury in rat kidneys, 2) the effect of DWH-146e is A2A receptor mediated, and 3) the protective effects are mediated by preventing injury during the reperfusion period.
Statistics of light transport in 235-ring silicon coupled-resonator optical waveguides (2010)

In contrast to recent reports of localization-impaired transport in long slow-light waveguides, we demonstrate light transport in silicon coupled-resonator optical waveguides (CROWs) consisting of up to 235 coupled microrings without localization over frequency bands that are several hundred gigahertz wide. Furthermore, from the unique statistical signatures provided by time-domain propagation delay measurements, we demonstrate the spectrally correlated nature of light propagation in CROWs.
The use of myeloid hematopoietic growth factors in patients with HIV infection (1990)

Hematologic abnormalities are frequent occurrences in patients with HIV infection. Myelosuppression in AIDS may be due to multiple factors and has significant impact on the treatment of HIV-infected individuals, as it is the major dose-limiting toxicity of a number of antimicrobial compounds and chemotherapy. Both granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) are hematopoietic hormones which effect myeloid progenitor cells and enhance the function of mature neutrophils. Clinical studies of the effects of these agents in patients with AIDS indicate that GM-CSF and G-CSF can increase the production of leukocytes in a dose-dependent fashion. This increase in leukocyte production may allow the continued administration of full doses of antiviral or other myelosuppressive medications in previously hematologically intolerant patients with AIDS. Investigations of the hematopoietic, virologic, and immunologic effects of these agents alone and in combination with other hematopoietins, cytokines, and chemotherapeutic agents will ultimately define their clinical utility in patients with HIV infection.
Towards UHF RFID robust design tag (2010)

The paper presents a robust UHF tag for RFID application. The antenna design for the UHF tag is obtained from an automated antenna design tool developed to obtain original topologies in order to satisfy real environment RFID constraints. The approach is completely automatic and requires very little human interactions during the design process. The obtained prototype was measured and compared with the NXP FF95-8 inlay. The inlays were tagged in many disruptive elements to evaluate their sensitivity to the real RFID environment. The proposed inlay shows read range stability wherever used in free space or tagged on an object. It has a small size of 0.28¿ by 0.02¿ in the UHF frequency band. Regardless of the environment, the read range is relatively constant (variations from 5 m to 8 m are observed) on the whole worldwide RFID frequency bands [860-960 MHz].
Large‐Area 3D Nanostructures with Octagonal Quasicrystalline Symmetry via Phase‐Mask Lithography (2007)

3D nanostructured quasicrystalline materials significantly larger than feasible with previously reported techniques are produced. 2D quasiperiodic surface relief templates with 8mm point group symmetry are made by multiple-exposure interference lithography. Phase-mask lithography with corresponding PDMS masks produce bicontinuous 3D axial quasicrystal SU-8 structures (see figure).
Stereoscopic 3D display technique using spatiotemporal interlacing has improved spatial and temporal properties (2015)

Stereoscopic 3D (S3D) displays use spatial or temporal interlacing to send different images to the two eyes. Temporal interlacing delivers images to the left and right eyes alternately in time; it has high effective spatial resolution but is prone to temporal artifacts. Spatial interlacing delivers even pixel rows to one eye and odd rows to the other eye simultaneously; it is subject to spatial limitations such as reduced spatial resolution. We propose a spatiotemporal-interlacing protocol that interlaces the left- and right-eye views spatially, but with the rows being delivered to each eye alternating with each frame. We performed psychophysical experiments and found that flicker, motion artifacts, and depth distortion are substantially reduced relative to the temporal-interlacing protocol, and spatial resolution is better than in the spatial-interlacing protocol. Thus, the spatiotemporal-interlacing protocol retains the benefits of spatial and temporal interlacing while minimizing or even eliminating the drawbacks.
Acute Histologic Changes Associated with Endoureterotomy in the Normal Pig Ureter (1991)

Endosurgical management of ureteral strictures includes balloon dilation, cutting balloon (Acucise), and endoscopic incision with a cold knife, laser, or electrocautery. To date, there are no data regarding the acute tissue changes resulting from these interventions. Using the normal pig ureter, we evaluated each of the above modalities. The ureters were harvested 2 hours after dilation or incision. Histologic sections were graded for urothelial loss, inflammation, edema, and vascular injury. Balloon dilation resulted in minimal changes seen only in the lamina propria. No significant difference was noted in the amount of tissue injury produced by the cutting modalities. Incisions with the cutting balloon were performed with much less difficulty than those done endoscopically.
Structure and dynamic behavior in solution of binuclear nickel(II) face-to-face complexes with bis(cyclidene) ligands (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and dynamic behavior in solution of binuclear nickel(II) face-to-face complexes with bis(cyclidene) ligandsNaomi Hoshino, Kenneth A. Goldsby, and Daryle H. BuschCite this: Inorg. Chem. 1986, 25, 17, 3000–3006Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ic00237a015https://doi.org/10.1021/ic00237a015research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts