gebhart/patrepeval huggingface dataset:
Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd:YAG laser: early clinical results (1990)

We performed a clinical trial to evaluate the safety and efficacy of a unique lensed-fiber delivery system with a pulsed Neodymium-yttrium aluminum garnet (Nd-YAG) laser in patients with atherosclerotic peripheral vascular disease. The lensed-fiber consists of a spherical silica lens, 1 .5 mm in diameter, mounted at the distal tip of a 300 im silica optical fiber. The Nd-YAG laser is pulsed at 10 Hz, and we delivered 0.5 J/pulse with a pulse duration of 100 msecs in 2- to 5-second bursts. Successful recanalization of stenoses or occlusions was obtained in 9 of 10 patients and was manifested by improvement in blood flow as measured angiographically and with ankle-brachial blood pressure index improvement (> 0. 15). There were no arterial perforations or dissections associated with the laser angioplasty. All successfully recanalized patients required adjunctive balloon angioplasty to obtain a satisfactory reduction in luminal diameter stenosis of the treated artery. We conclude that this unique delivery system and the pulsed Nd-YAG laser are a safe and effect method of recanalizing arterial stenoses not amenable to conventional balloon angioplasty alone.
Nanoalloy catalysis and magnetic and optical properties: general discussion (2022)

Nanoalloy catalysis, part 3 Ewald Janssens opened a discussion of the paper by Daojian Cheng: Can you comment on the stability of the trimetallic PdAgCu catalysts? Does the structure of the nanoalloys change during the hydrogenation reaction? Daojian Cheng replied: In this
Particle Clearance in Human Bronchial Airways: Comparison of Stochastic Model Predictions with Experimental Data (2002)

A stochastic bronchial clearance model has been developed that is based on a probabilistic asymmetric structure of the human lung. This model takes mucociliary transport rates to be a function of airway diameter, considers delayed mucus clearance at bifurcation sites, and uses an empirically derived expression for the slow clearance fraction as a function of particle diameter. For the calculation of retention curves, this bronchial clearance model was applied to predicted deposition patterns for different particle sizes and breathing conditions. Two sets of experimental data were used: (i) bolus inhalation at different volumetric depths, and (ii) extremely slow inhalation, providing a wide range of initial deposition patterns. In general, excellent agreement was found between theoretical predictions and experimental retention data (short-term retention curves and 24 h retention values) for different particle sizes, with maximum differences between 10 and 20%. Two different mechanisms are discussed to interpret the experimentally observed relation between the slow clearance fraction and particle diameter.
Classifying the Data Semantics of Patches (2013)

Patching software remains a key defensive technique for mitigating flaws and vulnerabilities. Patches, however, entail complications that are hard to predict. Patches can be incomplete or incorrect, thereby not fully addressing the targeted flaw or introducing new bugs and unintended behavior. System administrators and owners are often at a loss to assess the risk that applying a patch might carry. Without a lengthy evaluation, they cannot predict how the patch will behave in or affect their environment. Such obstacles often prevent the use of hot patching or dynamic software updating. One major obstacle to hot patching arises from the desynchronization of existing data with the patch’s new code semantics. This paper adopts a machine learning approach to assist this kind of prediction: whether the patch contains elements that are likely to cause problems if the patch is applied to the running system. We drive this automated assessment (based on a Support Vector Machine) via an analysis of the control and data modification operations in the patch. Our SVM classifies a set of 25 unlabeled patches with 92% accuracy. As a baseline, it also classifies its testing set of 50 patches (blindly, without labels) with 84% accuracy.
Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study (2021)

Immunotherapy shows measurable efficacy in appendiceal cancer organoids. Information derived from immunocompetent organoids may be applied in selecting patients for clinical trial enrollment in rare diseases where preclinical models of disease are lacking.
Analytical Investigation of the Effect of Tool Wear on the Temperature Variations in a Metal Cutting Tool (1976)

An analytical study of the effect of crater wear on the response of a remote thermocouple sensor is described. The remote thermocouple sensor is at present being developed as a device for the on-line measurement of tool wear. This technique depends for its operation on the strong influence of wear on the transient temperature variations in the tool. The two-dimensional transient temperature variations in the chip and tool regions are determined using a numerical finite-difference technique. Results are obtained under idealized cutting conditions with a zero wear rate, a normal wear rate, and an accelerated wear rate. Comparisons are made between the three cases to develop relationships for the effect of wear on the temperature at the remote thermocouple location.
Sensitivity and Error Analysis in Conjunction with Tibial Intramedullary Guides in Total Knee Arthroplasty (2001)

In this study, the potential error in using intramedullary guides for tibial component positioning was investigated and quantified. The purpose of the study was to investigate whether intramedullary or extramedullary systems are superior for tibial component positioning. Radiographic evaluation was performed on twelve cadaveric tibiae. The anatomic axes on the anteroposterior and lateral views were identified and used to define the proper entry point on the proximal tibia. This entry point was found to be at the midpoint on the anteroposterior radiograph and one-third from the anterior on the lateral radiographs. A mathematical model was used to quantify the error induced by intramedullary guide rods with respect to cutting guide rotation, rod angulation secondary to a geometric mismatch, and improper entry point. Rods of two lengths (4 and 7 inches) and diameters (7 and 8 mm) were used to calculate the potential errors. Significant varus/valgus deviations were seen with shorter and thinner rods; entry point misplacement and cutting guide malrotation magnified these errors. This study highlights the importance of guide limitations and the causes of component malpositioning.
Electronically beam steerable lens antenna for 71&#x2013;76/81&#x2013;86 GHz backhaul applications (2015)

Design of an electronically beam steerable integrated lens antenna suitable for 71-76/81-86 GHz backhaul applications is presented. The lens is made from a thermoplastic material and has the aperture size (diameter) of 260 mm ensuring a half power beam width below 1°. The beam steering capability is provided by an antenna array of 4 microstrip patch feed elements and a single pole four through MMIC switch mounted on a high frequency printed circuit board. The half-power (-3 dB) overlapping level of the adjacent beams is achieved by selecting a proper distance between the feed elements in the array. The lens antenna has a WR-12 waveguide interface and can be easily integrated with traditional millimeter-wave radio systems. Measurement results of the fabricated lens antenna prototype with electronic beam steering are provided. A successful trial of the prototype was performed with a commercial 71-76/81-86 GHz system during a 3-month test at a mobile operator's network.
Evidence of bias in randomized clinical trials of hepatitis C interferon therapies (2017)

Our study indicates the same treatment is more effective when labeled "experimental" compared to when labeled "control" in a setting of trials using an objective endpoint and even after adjusting for patient and study-level characteristics. We discuss several factors related to design and conduct of hepatitis C trials as potential explanations of the bias toward the experimental treatment.
Flexible Organic Circuits with Printed Gate Electrodes (2003)

Pentacene transistors and integrated circuits on flexible substrates (see Figure) have been fabricated with gate electrodes prepared using a purely additive process combining microcontact printing and selective electroless plating. The printed metal patterns have a resolution of better than 5 μm. Transistors have a carrier mobility of 0.06 cm 2 V –1 s –1 and an on/off current ratio of 10 6 . Ring oscillators have a signal propagation delay of 170 μs per stage.
DER Information Unaware Coordination via Day-ahead Dynamic Power Bounds (2020)

Reliability and voltage quality in distribution networks have been achieved via a combination of transformer power rating satisfaction and voltage management asset control. To maintain reliable operation under this paradigm, however, future grids with deep DER penetrations would require costly equipment upgrades. These upgrades can be mitigated via judicious coordination of DER operation. Earlier work has assumed a hierarchical control architecture in which a global controller (GC) uses detailed power injection and DER data and knowledge of DER owners' objectives to determine setpoints that local controllers should follow in order to achieve reliable and cost effective grid operation. Having such detailed data and assuming knowledge of DER owners' objectives, however, are often not desirable or possible. In an earlier work, a 2- layer DER coordination architecture was shown to achieve close to optimal performance despite infrequent (e.g., once per day) communication to a global controller. Motivated by this work, this paper proposes a day-ahead coordination scheme that uses forecasted power profile ranges to generate day-ahead dynamic power rating bounds at each transformer. Novel features of this scheme include: (i) the GC knows only past node power injection data and does not impose or know DER owner objectives, (ii) we use bounds that ensure reliable operation to guide the local controllers rather than setpoint tracking, and (iii) we consider electric vehicle (EV) charging in addition to storage. Simulations using the IEEE 123-bus network show that with random placements of 50% solar, 50% EVs and only 10% storage penetrations, the uncoordinated approach incurs rating violations at nearly all 86 transformers and results in 10 times higher voltage deviation, while our approach incurs only 12 rating violations and maintains almost the same voltage deviations as before the addition of solar and EVs.
Comparison of the pharmacokinetic, pharmacodynamic, and safety profiles of three different formulations of intravenous epoprostenol sodium (2012)

A change in excipient of epoprostenol sodium, an i.v. pulmonary arterial hypertension treatment, from glycine-mannitol (epoprostenol GM; Flolan®) to arginine-mannitol (epoprostenol AM; Veletri®) or to undisclosed excipients (epoprostenol XX) has led to improvements in stability of the latter two formulations. The pharmacokinetic (PK), haemodynamic, safety, and tolerability profiles of these formulations were compared in this 2-part study. 20 healthy males in Part 1 and 20 different subjects in Part 2 received epoprostenol AM and epoprostenol XX, and epoprostenol GM and epoprostenol XX, respectively, in a crossover design, in sequential 2h i.v. infusions of 2, 4, 6 and 8 ng/kg/min. PK profiles were assessed by analysing plasma concentration-time curves of the primary epoprostenol metabolites 6-keto-prostacyclin F1α (kPF) and 6,15-diketo-13,14-dihydro-prostacyclin F1α (ddPF) obtained after treatment with the different epoprostenol formulations. For Part 1, the ratio of the geometric means (90% CI) of AUC 0–∞ calculated after epoprostenol AM and epoprostenol XX treatment was 0.91 (0.88–0.95) for kPF and 0.88 (0.84–0.92) for ddPF. For Part 2, the ratio of AUC 0–∞ determined after epoprostenol GM and epoprostenol XX treatment was 0.97 (0.91–1.03) for kPF and 1.08 (1.02–1.14) for ddPF. Haemodynamic variables, assessed by echocardiography, showed similar increases in cardiac output, cardiac index, and heart rate for all formulations with maximum values attained after 6–8h. Almost all subjects reported ≤1 adverse event. These results suggest the 3 formulations of i.v. epoprostenol sodium have the same PK, haemodynamic, safety, and tolerability profiles.
Glutathione-S-transferases and Chemotherapy Resistance of Hodgkin's Lymphoma Cell Lines. (2016)

Our data suggest that the combined treatment with chemotherapy and GST inhibitors such as EA might be an interesting option for patients with chemoresistant HL.
Resistive switching characteristics and mechanisms of Pt-embedded SrZrO3 memory devices (2010)

The effects of embedded Pt (E-Pt) metal layer on the resistive switching characteristics and mechanisms of SrZrO3 (SZO) memory devices are investigated in this study. The E-Pt is shown by transmission electron microscopy observation to thermally diffuse into SZO thin film to form E-Pt clusters and no chemical reaction occurs between Pt and SZO during 600 °C postannealing process. The carrier transport of high resistance state current of 600 °C E-Pt devices is dominated by Ohmic conduction and Frenkel–Poole (F–P) emission in the low- and high-voltage region, respectively, which is quite different from that of without E-Pt memory devices being principally dominated by F–P emission. Furthermore, the forming voltage and turn-on voltage of E-Pt devices are significantly lowered to −3.5 V and |2.3| V, respectively, due to the reduction in effective thickness of SZO thin films caused by E-Pt clusters formed, which benefit the future development of resistive random access memory devices in practical application.
Letters (2013)

Children's Hospital & Health Center San Diego, CA The device(s)/drug(s) is/are FDA approved or approved by corresponding national agency for this indication. Institutional research grant funds from the John and Marcella Fox Research Fund via Washington University were received in support of this work. Relevant financial activities outside the submitted work: board membership, consultancy, grants/grants pending, payment for lectures, patents, royalties, payment for development of educational presentations and stock/stock options.
Tools for High‐Resolutionin vivoImaging of Cellular and Molecular Mechanisms in Cortical Spreading Depression and Spreading Depolarization (2017)

Cortical spreading depression (CSD) – the underlying cause of migraine aura – is a wave of electrophysiological hyperactivity followed by a wave of inhibition. Although mechanisms of CSD are poorly understood, the CSD phenomenon is known to associate with an increase in intracellular Ca2+ in neurons and astrocytes, hypoxia, and a spreading wave of vascular diameter changes, most commonly manifested as an initial constriction, followed by a partial dilation and sustained constriction. In this chapter, we review a number of high-resolution imaging tools, including quantification of intracellular calcium, partial pressure of O 2, and energy metabolites that may help to elucidate the chain of events underlying neurovascular and neurometabolic mechanisms of CSD.
Computerized Analysis of MR and Ultrasound Images of Breast Lesions (2000)

Although general rules for the differentiation between benign and malignant mammographically identified breast lesions exist, considerable misclassification of lesions occurs with the current methods. The main goal of the proposed research is to develop noninvasive, computerized methods for analyzing ultrasound and MR (magnetic resonance) images of breast lesions to aid radiologists in their workup of suspect lesions. We currently have retrospectively collected over 400 ultrasound cases of mass lesions, all that had gone on to either biopsy or cyst aspiration. We extracted and calculated features related to lesion margin, shape, homogeneity (texture) and the nature of the posterior acoustic attenuation pattern. Linear discriminant analysis round-robin runs yielded Az values of 0.94 and 0.87 in the task of distinguishing between benign and malignant lesions in the entire database and the equivocal database, respectively. The "equivocal" database contained lesions that had been proven to be benign or malignant by either cyst aspiration or biopsy. Dynamic MR data was analyzed with the computerized classification method, which includes temporal features of normalized speed and inhomogeneity of uptake, and spatial features of margin descriptors such as circularity and irregularity. Results indicate that classification based on temporal and spatial features combined can yield a positive predictive value of 94%, and has the potential to reduce the number of unnecessary biopsies by approximately 92%. We also have developed a new method for automatically extracting the lesion from the 3D image set of the breast. ROC analysis yielded Az values of 0.90 when the manual segmentation was used in the classification and 0.93 when automatic segmentation was included.
Noise penalty caused by stimulated Raman scattering in bidirectional DWDM transmission (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. M. Krummrich, A. Mayer, and G. Fischer, "Noise penalty caused by stimulated Raman scattering in bidirectional DWDM transmission," in Optical Amplifiers and their Applications, S. Kinoshita, J. Livas, and G. van den Hoven, eds., Vol. 30 of Trends in Optics and Photonics (Optica Publishing Group, 1999), paper ThB3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Deep Online Video Stabilization (2018)

Video stabilization technique is essential for most hand-held captured videos due to high-frequency shakes. Several 2D-, 2.5D- and 3D-based stabilization techniques are well studied, but to our knowledge, no solutions based on deep neural networks had been proposed. The reason for this is mostly the shortage of training data, as well as the challenge of modeling the problem using neural networks. In this paper, we solve the video stabilization problem using a convolutional neural network (ConvNet). Instead of dealing with offline holistic camera path smoothing based on feature matching, we focus on low-latency real-time camera path smoothing without explicitly representing the camera path. Our network, called StabNet, learns a transformation for each input unsteady frame progressively along the time-line, while creating a more stable latent camera path. To train the network, we create a dataset of synchronized steady/unsteady video pairs via a well designed hand-held hardware. Experimental results shows that the proposed online method (without using future frames) performs comparatively to traditional offline video stabilization methods, while running about 30 times faster. Further, the proposed StabNet is able to handle night-time and blurry videos, where existing methods fail in robust feature matching.
Search for microscopic black hole signatures at the Large Hadron Collider (2011)

A search for microscopic black hole production and decay in pp collisions at a center-of-mass energy of 7 TeV has been conducted by the CMS Collaboration at the LHC, using a data sample corresponding to an integrated luminosity of 35 pb(-1). Events with large total transverse energy are analyzed for the presence of multiple high-energy jets, leptons, and photons, typical of a signal expected from a microscopic black hole. Good agreement with the standard model backgrounds, dominated by QCD multijet production, is observed for various final-state multiplicities and model-independent limits on new physics in these final states are set. Using simple semi-classical approximation, limits on the minimum black hole mass are derived as well, in the range 3.5-4.5 TeV. These are the first direct limits on black hole production at a particle accelerator. (c) 2011 CERN. Published by Elsevier B.V. All rights reserved.
In‐Line Monitoring of Size Distributions in Liquid‐Liquid Dispersions and Suspension Polymerizations by Focused Beam Reflectance Measurements (2014)

Summary This work studies the use of Focused Beam Reflectance Measurements (FBRM) for monitoring of size distributions in liquid‐liquid (styrene‐water) dispersions and styrene suspension polymerizations performed in stirred tanks. The effects of the suspending agent concentration, stirring rate and presence of external light sources on the FBRM performance were evaluated during the in‐line monitoring of average size chords and chord length distribution (CLD). It can be stated that FBRM is sensitive to variations of particle sizes and, therefore, that FBRM is suitable for evaluation of CLDs in real time in suspension polymerization systems.
The effect of interface properties on nickel base alloy composites. Final report (1995)

This program was performed to assess the extent to which mechanical behavior models can predict the properties of sapphire fiber/nickel aluminide matrix composites and help guide their development by defining improved combinations of matrix and interface coating. The program consisted of four tasks: (1) selection of the matrices and interface coating constituents using a modeling-based approach; (2) fabrication of the selected materials; (3) testing and evaluation of the materials; and (4) evaluation of the behavior models to develop recommendations. Ni-50Al and Ni-20AI-30Fe (a/o) matrices were selected which gave brittle and ductile behavior, respectively, and an interface coating of PVD YSZ was selected which provided strong bonding to the sapphire fiber. Significant fiber damage and strength loss was observed in the composites which made straightforward comparison of properties with models difficult. Nevertheless, the models selected generally provided property predictions which agreed well with results when fiber degradation was incorporated. The presence of a strong interface bond was felt to be detrimental in the NiAI MMC system where low toughness and low strength were observed.
Comparative Analysis of Acid Sphingomyelinase Distribution in the CNS of Rats and Mice Following Intracerebroventricular Delivery (2011)

Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we reported that biochemical and functional abnormalities observed in ASM knockout (ASMKO) mice could be partially alleviated by intracerebroventricular (ICV) infusion of hASM. We now show that this route of delivery also results in widespread enzyme distribution throughout the rat brain and spinal cord. However, enzyme diffusion into CNS parenchyma did not occur in a linear dose-dependent fashion. Moreover, although the levels of hASM detected in the rat CNS were determined to be within the range shown to be therapeutic in ASMKO mice, the absolute amounts represented less than 1% of the total dose administered. Finally, our results also showed that similar levels of enzyme distribution are achieved across rodent species when the dose is normalized to CNS weight as opposed to whole body weight. Collectively, these data suggest that the efficacy observed following ICV delivery of hASM in ASMKO mice could be scaled to CNS of the rat.