gebhart/patrepeval huggingface dataset:
Nutritional biochemistry of curcumin (diferuloylmethane) and a review of its biological actions on articular chondrocytes (2011)

Curcumin (diferuloylmethane) is the principle biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and anti-oxidant, properties. In this chapter we provide a brief review of osteoarthritis (OA) and discuss the anti-inflammatory properties of curcumin in the context of its actions on articular chondrocytes. We highlight its potential benefits and drawbacks for treating OA and related osteoarticular conditions. Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin (IL)-1 beta (IL-1) including matrix metalloproteinase-3 (MMP-3) upregulation, inhibition of collagen type II and down-regulation of β1-integrin expression. Curcumin blocks IL-1-induced proteoglycan degradation, Nuclear Factor Kappa B (NF-B) signaling, chondrocyte apoptosis and activation of caspase-3. The available data from in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals could become suitable nutritional and nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA. © 2010 Nova Science Publishers, Inc. All rights reserved.
Novel three-phase AC-DC-AC sparse matrix converter (2003)

A novel three-phase AC-DC-AC sparse matrix converter (SMC) having no energy storage elements in the DC link and employing only 15 IGBTs as opposed to 18 IGBTs of a functionally equivalent conventional AC-AC matrix converter (CMC) is proposed. It is shown that the realization effort could be further reduced to only 9 IGBTs (ultra sparse matrix converter, USMC) in case the phase displacement of the fundamentals of voltage and current at the input and at the output is limited to /spl plusmn//spl pi//6. The dependency of the voltage and current transfer ratios of the systems on the operating parameters is analyzed and a space vector modulation scheme is described in combination with a zero current commutation procedure. Furthermore, a safe multi-step current commutation concept is treated briefly. Conduction and switching losses of the SMC and USMC are calculated in analytically closed form. Finally, the theoretical results are verified in Part II of the paper by digital simulations and results of a first experimental investigation of a 10 kW/400 V SMC prototype are given.
A framework for annotating CSV-like data (2016)

In this paper, we propose a simple and expressive framework for adding metadata to CSV documents and their noisy variants. The framework is based on annotating parts of the document that can be later used to read, query, or exchange the data. The core of our framework is a language based on extended regular expressions that are used for selecting data. These expressions are then combined using a set of rules in order to annotate the data. We study the computational complexity of implementing our framework and present an efficient evaluation algorithm that runs in time proportional to its output and linear in its input. As a proof of concept, we test an implementation of our framework against a large number of real world datasets and show that it can be efficiently used in practice.
A Simplified Method To Create Quantitative, “Fixed” Uranyl-Contaminated Metal Coupons (2004)

A method was developed and validated to quantitatively apply and "fix" uranyl contamination onto a metal surface (steel). Simple approaches are needed to create test surfaces in order to quantify contaminant removal or "decon" methods. We used steel discs sized to allow direct and accurate alpha counting in a Ludlum scanner from radioactive contaminants. A typical 3.8-cm-diameter coupon had a depleted uranyl loading of about 0.1 mg U cm with a count of 980 dpm. The resulting alpha radiation was measured with a precision of >97% for the same coupon. The alpha concentration on replicate coupons differed by as much as 9% (standard deviation). This method, based on earlier methods, required a uranyl solution to be dried but lowers the baking temperature to less than 100°C to increase safety in a typical radiological laboratory. A dike was used to provide a uniform coating of the uranyl solution.
Separation of reflections via sparse ICA (2004)

In this paper, we consider the problem of recovery of a scene recorded through a semireflective medium from its mixture with a virtual reflected image using the blind source separation (BSS) framework. We extend the sparse ICA (SPICA) approach and apply it to the separation of the desired image from the superimposed images, without having any a priory knowledge about its structure and/or statistics. Advances in the SPICA approach are discussed. Simulations and experimental results illustrate the efficiency of the proposed approach, and of its specific implementation in a simple algorithm of a low computational cost. The approach and the algorithm are generic and can be adapted and applied to a wide range of BSS problems involving one-dimensional signals or images.
Dual Modal Three dimensional Imaging of Single Cell using Optical Projection Tomography Microscope (2009)

The optical projection tomography microscope (OPTM) acquires three-dimensional images of single cells with isometric high resolution both in absorption and fluorescence modes, employing computed tomographic image reconstruction. The three-dimensional chromosome structure of a female muntjac cell is shown.
Managing gravidas with von Willebrand disease or factor XI deficiency (2007)

These patients have either a qualitative or quantitative deficiency of von Willebrand factor (VWF). Critical for primary hemostasis, VWF functions to bridge platelets to vascular subendothelium and to other platelets and to promote the formation of fibrin clots by serving as a carrier protein for factor VIII.
Transscleral passive and iontophoretic transport: theory and analysis (2017)

QSPR was examined for passive transscleral permeation, showing correlations between logarithm of permeability coefficient and logarithm of molecular weight. Potential causes of data variability were proposed. QSPR were established for electroosmosis using the molecular weight of neutral permeants and for iontophoresis enhancement using the molecular weight and charge of ionic permeants. However, QSPR for charged macromolecules were empirical; iontophoretic flux enhancement was significantly smaller than Nernst-Planck model prediction due to complicating factors.
K/DOQI ACCESS FLOW (AF) THRESHOLD GUIDELINES - IS THERE A THEORETICAL BASIS? (2001)

Towards the surveillance for hemodynamically significant stenoses (≥50% reduction of graft diameter accompanied by hemodynamic abnormalities), the K/DOQI Guidelines recommend that patients be referred for fistulogram if AF is less than 600 ml/min, or if AF is less than 1000 ml/min and has decreased by more than 25% over 4 months. To assess the applicability of this recommendation to a wide range of patients with grafts of different sizes and locations, a mathematical model was developed using available clinical and experimental data. Mathematical Model The total hemodynamic resistance of the vascular access system was considered to be Z = Za + Zaa + Zg + Zva + Zs where the individual resistances are those of the supplying artery, arterial anastamosis, intragraft region, venous anastamosis, and a stenotic region, respectively. The resistance of the stenotic region was calculated using a modified Poiseuille Equation and the following parameters:TableResults The model produced an AF time profile with three distinct periods. Period 1 was characterized by a small, less then 10% decrease in AF over the initial 3 – 8 months (depending on initial AF, stenosis growth rate, and stenosis location). Percent stenosis ranged from 10 – 40%. Period 2 was characterized by a 10 – 30% decrease in AF and a quickly progressing stenosis of size 50% or more. Period 3 was characterized by a dramatic, more than 30% decrease in AF. AF was 400 ml/min or less, a situation that is clinically seen only in approximately 10% of patients. Summary Over a wide range of initial forearm AF rates, graft lengths, stenosis locations, and stenosis growth rates, the K/DOQI thresholds proved highly predictive of stenoses of 50% or more. For upper arm grafts, the absolute AF thresholds should be raised from 600 to S00 ml/min, and the decrease criteria should be applied to AF ± 1200 ml/min.
FRET detection of lymphocyte function–associated antigen-1 conformational extension (2014)

Lymphocyte function-associated antigen 1 (LFA-1, CD11a/CD18, αLβ2-integrin) and its ligands are essential for adhesion between T-cells and antigen-presenting cells, formation of the immunological synapse, and other immune cell interactions. LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension. However, the relationship between molecular conformation and function is unclear. Here fluorescence resonance energy transfer (FRET) with new LFA-1-specific fluorescent probes showed that triggering of the pathway used for T-cell activation induced rapid unquenching of the FRET signal consistent with extension of the molecule. Analysis of the FRET quenching at rest revealed an unexpected result that can be interpreted as a previously unknown LFA-1 conformation.
Gossyplure in Laminated Plastic Formulations for Mating Disruption and Pink Bollworm Control12 (1981)

Journal Article Gossyplure in Laminated Plastic Formulations for Mating Disruption and Pink Bollworm Control Get access T. J. Henneberry, T. J. Henneberry Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. Gillespie, J. M. Gillespie Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar L. A. Bariola, L. A. Bariola Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar H. M. Flint, H. M. Flint Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar P. D. Lingren, P. D. Lingren Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar A. F. Kydonieus A. F. Kydonieus Agricultural Research Science and Education Administration, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 74, Issue 4, 1 August 1981, Pages 376–381, https://doi.org/10.1093/jee/74.4.376 Published: 01 August 1981 Article history Received: 04 April 1980 Published: 01 August 1981
Automatic smart contract generation using controlled natural language and template (2019)

Smart contracts, which are widely recognized as key components of blockchain technology, enable automatic execution of agreements. Since each smart contract is a computer program that autonomously runs on a blockchain platform, their development requires much effort and care compared with the development of more common programs. In this paper, we propose a technique to automatically generate a smart contract from a human-understandable contract document that is created using a document template and a controlled natural language (CNL). The automation is based on a mapping from the document template and the CNL to a formal model that can define the terms and conditions in a contract including temporal constraints and procedures. The formal model is then translated into an executable smart contract. We implemented a toolchain that generates smart contracts of Hyperledger Fabric from template-based contract documents via a formal model. We then evaluated the feasibility of our approach through case studies of two types of real-world contracts in different domains.
Long-term Outcome of Endoscopic Retrograde Biliary Drainage of Biliary Stricture Following Living Donor Liver Transplantation (2019)

<b>Background/Aims:</b> Biliary strictures remain one of the most challenging aspects after living donor liver transplantation (LDLT). The aim of this study was to assess long-term outcome of endoscopic treatment of biliary strictures occurring after LDLT and to identify risk factors of recurrent biliary strictures following endoscopic retrograde biliary drainage (ERBD) in LDLT. <b>Methods:</b> A total of 1,106 patients underwent LDLT from May 1995 to May 2014. We compared the risk factors between patients with and without recurrent biliary strictures. <b>Results:</b> Biliary strictures developed in 24.0% of patients. Technical success rate of ERBD for biliary stricture after LDLT was 66.2% (145/219). Among 145 patients managed by endoscopic drainage, stricture resolution occurred in 69 with median duration of stent indwelling of 13.6 months (range, 0.5 to 67.3 months), and stricture recurrence was seen in 20 (21.3%) out of 94. The median recurrence-free duration after final endoscopic success was 13.1 months (range, 0.5 to 67.3 months). Older donor age (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.03 to 1.17; p=0.004) and non-B, non-C liver cirrhosis (HR, 5.10; 95% CI, 1.10 to 25.00; p=0.043) were associated with higher recurrence of biliary stricture. <b>Conclusions:</b> Long-term stricture resolution rate after ERBD insertion for biliary stricture occurring after LDLT was 73.4%. Clinicians should pay careful attention during following-up to decide when to remove ERBD in patients who have factors associated with recurrent biliary strictures.
Nanosilicon‐Based Thick Negative Composite Electrodes for Lithium Batteries with Graphene as Conductive Additive (2013)

Abstract Reduced graphene oxide (rGO) is used as a conductive additive for nanosilicon‐based lithium battery anodes with the high active‐mass loading typically required for industrial applications. In contrast to conventional Si electrodes that use acetylene black (AcB) as an additive, the rGO system shows pronounced improvement of electrochemical performance, irrespective of the cycling conditions. With capacity limitation, the rGO system results in improved coulombic efficiency (99.9%) and longer cycle life than conventional electrodes. Upon cycling without capacity limitation, much higher discharge capacity is maintained (2000 mAh g −1 after 100 cycles for 2.5 mg of Si cm −2 ). Used in conjunction with the bridging carboxymethyl cellulose binder, the crumpled and resilient rGO allows highly reversible functioning of the electrode in which the Si particles repeatedly inflate and deflate upon alloying and dealloying with lithium.
Telehealth‐guided home‐based maggot debridement therapy for chronic complex wounds: Peri‐ and post‐pandemic potential (2020)

Patients with complex chronic lower extremity wounds require a great deal of interaction with outpatient and inpatient services. Paradoxically, these are the very patients that, because of their chronic comorbidities, are at greatest risk for COVID-related morbidity and mortality. Disinfected Phaenicia (Lucilia) sericata (Medical Maggots; Monarch Labs, Irvine, California) were applied in a standardised fashion by a home-health nurse with direct monitoring, guidance, and collaboration of the attending surgeon. A family member was able to change the outer dressing daily based on normal wound exudate. The inner maggot debridement therapy (MDT) dressing was changed at 2 days showing dramatic reduction in necrotic tissue, elimination of profound malodor, and no evidence of local or advancing infection. The entire initial telehealth-guided application took approximately 20 minutes. The first telehealth-guided MDT dressing change took 14 minutes. We used an artificial-intelligence-based algorithm to measure changes in wound characteristics. At day 0, 46% of the total surface area was covered in malodorous black, necrotic tissue. The first dressing change saw an elimination in assessed malodor with necrotic tissue constituting 14% of total surface area. The second dressing change at 5 days showed a greater than 99% reduction in necrotic tissue. This manuscript constitutes what we believe to be the first telehealth-guided MDT conducted during a resource-limited peri-pandemic period. We believe that MDT, which is an extension of efforts regularly performed in clinic and hospital, may have the potential to reduce resource usage while potentially improving care and quality of life for people with limb and life-threatening complications of diabetes and other chronic diseases.
Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step (2015)

Often when generating recombinant affinity reagents to a target, one singles out an individual binder, constructs a secondary library of variants, and affinity selects a tighter or more specific binder. To enhance the throughput of this general approach, we have developed a more integrated strategy where the "affinity maturation" step is part of the phage-display pipeline, rather than a follow-on process. In our new schema, we perform two rounds of affinity selection, followed by error-prone PCR on the pools of recovered clones, generation of secondary libraries, and three additional rounds of affinity selection, under conditions of off-rate competition. We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins: ubiquitin-conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen-activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11). The affinities of the resulting monobodies are typically in the single-digit nanomolar range. We demonstrate the utility of two binders by pulling down the targets from a spiked lysate of HeLa cells. This integrated approach should be applicable to directed evolution of any phage-displayed affinity reagent scaffold.
MRI-compatible hands-on cooperative control of a pneumatically actuated robot (2009)

MRI compatible robots are emerging as useful tools for image guided interventions. A shared control between a user and the MRI compatible robot makes it more intuitive instrument especially during setup phases of interventions. We present a MRI compatible, hands-on cooperative system using Innomotion robotic arm. An economic MRI compatible user input sensor was developed and its functionality was tested under typical application conditions. Performance improvement in phantom tasks shows promise of adding hands-on interface in MRI compatible robots.
Peptides derived from IgE heavy chain constant region induce profound IgE isotype‐specific tolerance (1996)

(BALB/c x SJL)F1 mice, perinatally injected with peptide-N-glyconase F-treated, deglycosylated IgE heavy chain or recombinant IgE heavy chain (CH epsilon 2-CH epsilon 4), were profoundly inhibited in antigen-specific IgE production. There exist minimally two tolerogenic IgE peptides, residing in the CH epsilon 2 and CH epsilon 4 domains. Peptide I, generated by V8 protease, comprises 39 amino acids within CH epsilon 2, beginning at amino acid 103. Peptide E begins at amino acid 312 of the CH epsilon 4 domain and extends through the CH epsilon 4 domain. The total lack of antigen-specific IgE responses in IgE peptide-treated mice was not due to overproduction of interferon-gamma, nor lack of interleukin (IL)-4, as predicted by the Th2/IL-4 paradigm for IgE production. IgE-tolerant mice exhibited comparable levels of circulating anti-IgE antibodies to those of PBS-treated control mice. IgG obtained from sera of both sources failed to inhibit IgE responses in vitro. Moreover, IgE responses of spleen cells from IgE peptides-treated mice were restored by CD4+ T cells from PBS-treated control mice. We hypothesize that regulation of antigen-specific IgE responses is mediated by CD4+ T cells which normally recognize IgE peptides on IgE precursor B cells, and can be rendered tolerant by perinatal IgE peptide treatment.
Isolation of a Highly Thermal Stable Lama Single Domain Antibody Specific for Staphylococcus aureusEnterotoxin B (2011)

The anti-SEB sdAb A3 was found to have a high affinity and an extraordinarily high Tm and could still refold to recover activity after heat denaturation. This combination of heat resilience and strong, specific binding make this sdAb a good candidate for use in antibody-based toxin detection technologies.
Building applied natural language generation systems (1997)

In this article, we give an overview of Natural Language Generation (NLG) from an applied system-building perspective. The article includes a discussion of when NLG techniques should be used; suggestions for carrying out requirements analyses; and a description of the basic NLG tasks of content determination, discourse planning, sentence aggregation, lexicalization, referring expression generation, and linguistic realisation. Throughout, the emphasis is on established techniques that can be used to build simple but practical working systems now. We also provide pointers to techniques in the literature that are appropriate for more complicated scenarios.
Separation of semireflective layers using sparse ICA (2003)

We address the problem of blind source separation (BSS) of superimposed images and, in particular, consider the recovery of a scene recorded through a semireflective medium (e.g. glass windshield) from its mixture with a virtual reflected image. We extend the sparse ICA (SPICA) approach to BSS and apply it to the separation of the desired image from the superimposed images, without having any a priori knowledge about its structure and/or statistics. Advances in the SPICA approach are discussed. Simulations and experimental results illustrate the efficiency of the proposed approach, and of its specific implementation in a simple algorithm of a low computational cost. The approach and the algorithm are generic in that they can be adapted and applied to a wide range of BSS problems involving one-dimensional signals or images.
Spreading sequences for multicarrier CDMA systems (1999)

The paper contains an analysis of the basic criteria for the selection of spreading sequences for the multicarrier CDMA (MC-CDMA) systems with spectrum spreading in the frequency domain. It is shown that the time-domain crosscorrelation function between the spreading sequences is not a proper interference measure for the asynchronous MC-CDMA users. Therefore, the spectral correlation function is introduced and, together with the crest factor and the dynamic range of the corresponding multicarrier waveforms, is used for the evaluation of MC-CDMA sequences. Some well-known classes of sequences, such as Walsh, Gold, orthogonal Gold, and Zadoff-Chu sequences, as well as Legandre and Golay complementary sequences, are evaluated with respect to the aforementioned basic criteria. It is also shown that the crest factors of the multicarrier spread spectrum waveforms based on the multilevel Huffman sequences are very close to or even lower than the crest factor of a single sine wave.