gebhart/patrepeval huggingface dataset:
Exploiting ordered dictionaries to efficiently construct histograms with q-error guarantees in SAP HANA (2014)

Histograms that guarantee a maximum multiplicative error (q-error) for estimates may significantly improve the plan quality of query optimizers. However, the construction time for histograms with maximum q-error was too high for practical use cases. In this paper we extend this concept with a threshold, i.e., an estimate or true cardinality θ, below which we do not care about the q-error because we still expect optimal plans. This allows us to develop far more efficient construction algorithms for histograms with bounded error. The test for θ, q-acceptability developed also exploits the order-preserving dictionary encoding of SAP HANA. We have integrated this family of histograms into SAP HANA, and we report on the construction time, histograms size, and estimation errors on real-world data sets. In virtually all cases the histograms can be constructed in far less than one second, requiring less than 5% of space compared to the original compressed data.
Hormone regulation of tissue type plasminogen activator (tPA) gene expression in the ovaries during gonadotropin-induced ovulation (1992)

Hormone regulation of tissue type plasminogen activator (tPA) gene expression in the ovaries during gonadotropin-induced ovulation
EFFECT OF PRETREATMENTS ON PHYSICAL ATTRIBUTES OF DEHYDRATED GREEN BITTER GOURD (2021)

The present investigative study was conducted to assess the effect of different pretreatments individually and in combination on the physical quality attributes of pretreated and dehydrated green bitter gourd rings.The bitter gourd fruit being rich in medicinal properties especially for diabetic population is always in great demand throughout the year.Bitter gourd is a seasonal vegetable crop with poor shelf life and in order to make it available round the year, enhancing the shelf life of the produce is the need of the hour.Dehydration is the valuable method for storing this nutrient rich vegetable and with the help of mechanical driers for dehydration; a better quality product can be produced.The experiment was laid out in Factorial Completely Randomized Design with sixteen pre-treatments.With respect to the study conducted on the effect of pretreatments on the physical attributes of dehydrated green bitter gourd, it is pertinent to mention that the higher dehydration and physical attributes were reported in samples subjected to pretreatments as compared to the control.The higher retention of physical attributes like rehydration ratio and bulk density indicates that the pretreated samples before dehydration were found to have better reconstitution than the control sample.These findings indicate that in overall, the pretreated samples showed significant effects on retention of physical quality attributes of green bitter gourd rings after dehydration than the control sample.This may turn out to be a better option for substitution of fresh produce in off-season along with better transport and storage dynamics.
Thymoma, Pure Red Cell Aplasia, Pernicious Anaemia and Candidiasis: a Defect in Immunohomeostasis (1977)

S ummary . A patient is reported who presented with anaemia and oral candidiasis. Investigation revealed a spindle cell thymoma, and a serum inhibitor of haem synthesis associated with pure red cell aplasia. He was also shown to have the Addisonian pernicious anaemia defect, diagnosed on the basis of a depressed serum level of vitamin B 12 , 57 Co‐cyanocobalamin absorption studies, the presence of intrinsic factor blocking antibodies and atrophic gastritis with an elevated serum gastrin level. A serum inhibitor of candida‐induced lymphocyte transformation, which may have accounted for the chronicity of the candidiasis, was also demonstrated. Following thyniectomy, whereas the antibodies to intrinsic factor and gastric mucosa, and the serum inhibitor of candida‐induced lymphocyte blastogenesis persisted, the inhibitor of haem synthesis disappeared. Moreover, red cell autoagglutinins, associated with a mildly shortened red cell life span, were detected for the first time. Although the patient's anaemia improved following thymectorny, mild megaloblastic changes were noted in the bone marrow. Parenteral vitamin B 12 therapy reversed these changes and a normal level of haemoglobin has subsequently been maintained. The candidiasis, however, has persisted. It is suggested that the defect in immunohomeostasis in the patient may have resulted from an abnormality or deficiency of specific suppressor T‐lymphocytes.
Real-time implementation of physical-layer network coding (2013)

This paper presents the first real-time physical-layer network coding (PNC) prototype for the two-way relay wireless channel (TWRC). Theoretically, PNC could boost the throughput of TWRC by a factor of 2 compared with traditional scheduling (TS) in the high signal-to-noise (SNR) regime. Although there have been many theoretical studies on PNC performance, there have been few experimental and implementation efforts. We built the first prototype of PNC about a year ago. It was, however, an offline system in which an offline PNC decoder was used at the relay. For a real-time PNC system, there are many additional challenges, including the needs for tighter coordination of the transmissions by the two end nodes, fast real-time PNC decoding at the relay, and a PNC-compatible retransmission scheme (i.e., an ARQ protocol) to ensure reliability of packet delivery. In this paper, we describe a real-time PNC prototype, referred to as RPNC, that provides practical solutions to these challenges. Indoor environment experimental results show that RPNC boosts the throughput of TWRC by a factor of 2 compared with TS, as predicted theoretically. RPNC prototype provides an interface to the application layer, with which we demonstrate the exchange of two image data files between the two end nodes.
Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA (2016)

Gastrin is a peptide hormone that is involved in the regulation of sodium balance and blood pressure. Dopamine, which is also involved in the regulation of sodium balance and blood pressure, directly or indirectly interacts with other blood pressure-regulating hormones, including gastrin. This study aimed to determine the mechanisms of the interaction between gastrin and dopamine and tested the hypothesis that gastrin produced in the kidney increases renal dopamine production to keep blood pressure within the normal range. We show that in human and mouse renal proximal tubule cells (hRPTCs and mRPTCs, respectively), gastrin stimulates renal dopamine production by increasing the cellular uptake of l-DOPA via the l-type amino acid transporter (LAT) at the plasma membrane. The uptake of l-DOPA in RPTCs from C57Bl/6J mice is lower than in RPTCs from normotensive humans. l-DOPA uptake in renal cortical slices is also lower in salt-sensitive C57Bl/6J than in salt-resistant BALB/c mice. The deficient renal cortical uptake of l-DOPA in C57Bl/6J mice may be due to decreased LAT-1 activity that is related to its decreased expression at the plasma membrane, relative to BALB/c mice. We also show that renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure. These results highlight the importance of renal gastrin in stimulating renal dopamine production, which may give a new perspective in the prevention and treatment of hypertension.
Diversification of the southern African clade C epidemic, over a period spanning 1998–2010, is associated with increased neutralization resistance. (2016)

&lt;p&gt;(A) Gp160 unrooted maximum likelihood phylogeny (PhymML) of protein sequences with sites greater than 5% gaps excluded, thereby disregarding hypervariable regions. Branches are colored according to sampling year category which was preselected based on numbers; warmer colors denoting earlier collected samples and cooler colors denoting samples collected later in the epidemic. (B) Protein ML phylogeny derived distances, estimated as branch lengths from root using the minimum sum of variance, correlated over time with calendar year. (C) Diversification (measured as branch length from root using the minimum sum of variance) inversely correlated with serum neutralization sensitivity. Rank correlations were performed using Kendall's rank correlation tau test. (D) Increasing resistance to antibody (bnAb) neutralization over the course of the clade C epidemic. bnAb susceptibility of clade C viruses from three distinct periods preselected based on numbers, 1998 to 2005 (n = 75), 2006 to 2007 (n = 55) and 2008 to 2010 (n = 70) tested against five bnAbs, VRC01, PG9, CAP256-VRC26.25, PGT128 and 4E10. The highest concentration tested for each bnAb and the percentage of viruses neutralized (breadth) are indicated. Placeholder constants of 50 μg/ml used for IC&lt;sub&gt;50&lt;/sub&gt; &gt;50 μg/ml (4E10), 10 μg/ml used for IC&lt;sub&gt;50&lt;/sub&gt; &gt;10 μg/ml (VRC01, PG9 and PGT128) and 25 μg/ml used for IC&lt;sub&gt;50&lt;/sub&gt; &gt;25 μg/ml (CAP256-VRC26.25). Box plots show representative IC&lt;sub&gt;50&lt;/sub&gt; titer distributions for each bnAb tested across each period with median IC&lt;sub&gt;50&lt;/sub&gt; represented by horizontal lines. Differences of neutralization sensitivity between viruses over calendar time were evaluated using the Jonckheere-Terpstra test for trend. Assays using starting concentrations of 10μg/ml were used for VRC01 data reported here.&lt;/p&gt;
SwissFEL KB-optics at-wavelength wavefront characterisation (2023)

Steering x-ray beams from the source towards the experiment without distorting their wavefront defines extraordinary high-quality requirements on the production of the x-ray optics. We report on how this demand settled with in situ shot-to-shot wavefront sensing optimization of KB optics at SwissFEL beamlines. This contribution presents methodology that combines moir´e interferometry and single-phase-grating Talbot interferometry. We discuss an online Kirkpatrick-Baez (KB) test plan at the Cristallina beamline based on single phase grating Talbot interferometry, demonstrating progressive optimization steps in minimizing KB wavefront distortion.
Formulation, identification and validation of mathematical models for plasma protein metabolic studies (1984)

The proper use of mathematical modelling techniques constitutes a useful aid in investigating dynamic metabolic processes such as those of the plasma proteins. From simple beginnings modelling methodology has evolved to a stage where models can provide both predictive and explanatory insights as well as yielding significant information with which to enhance the design of physiological and clinical experiments. This chapter aims to review the role of mathematical models in relation to plasma protein dynamics in health and disease.
On-chip interconnect trends, challenges and solutions: How to keep RC and reliability under control (2016)

Interconnects pose increasing challenges as technology scaling proceeds. In order to overcome these challenges simultaneous optimization of novel metallization schemes, new materials, circuit and system level approaches are required.
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure (2017)

Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) trimer. Using cryo-electron microscopy, we solved the atomic structure of an apex bnAb, PGT145, in complex with Env. We showed that the long anionic HCDR3 of PGT145 penetrated between glycans at the trimer 3-fold axis, to contact peptide residues from all three Env protomers, and thus explains its highly trimer-specific nature. Somatic hypermutation in the other CDRs of PGT145 were crucially involved in stabilizing the structure of the HCDR3, similar to bovine antibodies, to aid in recognition of a cluster of conserved basic residues hypothesized to facilitate trimer disassembly during viral entry. Overall, the findings exemplify the creative solutions that the human immune system can evolve to recognize a conserved motif buried under a canopy of glycans.
19-02: Electrocardiographic Mapping Vector Predicts Acute Response to Cardiac Resynchronization Therapy (2016)

Background: Endocardial voltage and late-gadolinium enhancement (LGE) are utilised as surrogate markers of fibrosis. Ablation of low voltage regions in PsAF has shown promising results, and LGE-CMRI defined scar guided ablation will be investigated in DECAAFII. We have reported the lack of correlation between AF voltage mapped over 1-2 AF cycles and LGE-scar. We hypothesised that increasing the sampling duration of AF voltage mapping allows for more accurate representation of the underlying structural substrate defined by LGE CMRI. Methods: Ten patients undergoing PsAF ablation underwent pre-procedural LGE-CMRI. Intra-procedural bipolar voltage mapping in AF was performed over 8s during 2 different AF epochs, where the mean peak-to-peak voltage (AF-V) at each site evaluated offline. A subset of patients underwent SR voltage (SR-V) mapping. Only data from the posterior LA wall as analysed as they represent best fidelity. The AF-V and SR-V in areas of LGE-scar, and areas of overlap of low voltage (LVA) (MPV ,0.4mV) and LGE-scar, were quantified. Reproducibility of the AF-V (with varying sampling durations) over 2 distinct AF epochs was also evaluated. Results: The AF-V in areas of LGE and non-LGE was 0.25 /-0.18 mV & 0.59 /-0.36 mV respectively (l2 norm 0.51). The mean SR-V was 2.19 /-1.90 mV & 3.21 /-2.43 respectively (l2 norm 0.13) (Fig. Surface overlap analysis was performed at thresholds 0.1-3.0 mV to detect for LGE. According to the ROC curve, the AF-V map detected for the presence of LGE with a sensitivity(Ss) of 74.7% and a specificity(Sp) of 63.4% at a threshold of 0.4 mV. The SR-V map had a Ss of 60.1% & Sp of 62.2% at a threshold of 2.0 mV. Acquired over 2 different AF epochs, increasing sampling durations increase ICCs (Fig
ChemInform Abstract: Mesoscopic Metal Particles and Wires by Electrodeposition (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gas storage in renewable bioclathrates (2012)

Methane and carbon dioxide can be stored in ‘bioclathrate’ form—that is, as a clathrate supported in a biological structure—by using plants or fungi to greatly accelerate clathrate formation kinetics, thus avoiding the use of energy-intensive mixing technologies or petrochemically derived materials.
New trialkylsilyl enol ether chemistry: intramolecular [2 + 2] cyclizations of .beta.-amido triisopropylsilyl enol ethers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew trialkylsilyl enol ether chemistry: intramolecular [2 + 2] cyclizations of .beta.-amido triisopropylsilyl enol ethersPhilip Magnus, Pascal Rigollier, Jerome Lacour, and Hans ToblerCite this: J. Am. Chem. Soc. 1993, 115, 26, 12629–12630Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00079a070https://doi.org/10.1021/ja00079a070research-articleACS PublicationsRequest reuse permissionsArticle Views307Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Transmutation Reactions and Associated Low-Energy Nuclear Reactions Effects in Solids (2008)

It has been found that cold fusion-type experiments can be designed to create nuclear reactions between the H or D in the electrolyte and the electrode lattice material. This field of research has been termed "Low Energy Nuclear Reactions (LENRs)". Studies of reaction (transmutation) products from LENRs are reviewed here, with emphasis on studies at UIUC using special thin-film electrodes designed to enhance such reactions. Evidence is presented for simultaneous production of excess heat (due to the exothermic nature of the reactions) and also low levels of very energetic (multi MeV) proton and alpha particles. Several theories have been proposed to address how the large coulombic field between reactants can be overcome in the highly loaded lattices. While these theories have attained some success in reproducing reaction product distributions, a number of theoretical issues remain open. Continued experimental/theoretical progress is bringing this basic research field closer to practical application as a power source or to drive transmutations for specific products.
Surfactant Modeling for Insight into Load-Recovery Enhancement for Fracturing Treatments (2011)

Abstract Load recovery from fracturing treatments in tight-gas sands is often considered to be an important indicator of success. Poor load recovery is often associated with poor performance, and used to invoke water blocks as a damage mechanism. Surfactants are designed and used to enhance load recovery, presumably by capillary pressure effects. A fit-for-purpose fracture cleanup and chemistry simulator (FCCS) was improved to study the impact of surfactant adsorption, surface-wettability changes, and surface-tension reduction on load recovery from hypothetical fracturing treatments. The simulator was improved by adding surfactant adsorption/desorption kinetics, wettability functions that were dependant on the amount of adsorption, and adsorption capacities. Simulations were conducted as a function of fracture conductivity, matrix relative permeability (rel-perm) quality, and various surfactant properties. It was found that surfactants have the greatest impact when matrix rel-perm functions are of moderately good quality or better. Surface-tension reduction alone tended to simply enhance imbibition, while changing wettability to near non-wet substantially enhanced load recovery. Fracture conductivity had a substantial role because it determined whether imbibition or drawdown won the battle over water movement. The methodology of the surfactant modeling is presented, along with the results from numerous simulations. This work demonstrates that surfactants can enhance load recovery under certain circumstances, with wettability changes being most important. However, matrix rel-perms must be of sufficient quality that capillary effects are able to overcome viscous effects.
Proactive seeding for information cascades in cellular networks (2012)

Online social networks (OSNs) play an increasingly important role today in informing users about content. At the same time, mobile devices provide ubiquitous access to this content through the cellular infrastructure. In this paper, we exploit the fact that the interest in content spreads over OSNs, which makes it, to a certain extent, predictable. We propose Proactive Seeding-a technique for minimizing the peak load of cellular networks, by proactively pushing (“seeding”) content to selected users before they actually request it. We develop a family of algorithms that take as input information primarily about (i) cascades on the OSN and possibly about (ii) the background traffic load in the cellular network and (iii) the local connectivity among mobiles; the algorithms then select which nodes to seed and when. We prove that Proactive Seeding is optimal when the prediction of information cascades is perfect. In realistic simulations, driven by traces from Twitter and cellular networks, we find that Proactive Seeding reduces the peak cellular load by 20%-50%. Finally, we combine Proactive Seeding with techniques that exploit local mobile-to-mobile connections to further reduce the peak load.
C2 Induced pluripotent stem cells (IPSC) as a model of huntington’s disease (2016)

<h3>Background and rationale</h3> Huntington’s disease (HD) patients’ cell lines may theoretically offer the opportunity to study longitudinal changes due to the mutated protein in its own physiological context. We are therefore exploring whether human induced pluripotent stem cells (iPSCs) from HD subjects represent a model to investigate the polyQ effects in vitro. <h3>Aims</h3> 1) Creation of an iPS collection from HD subjects; 2) Analysis of neural functions in reprogrammed cell lines, according to the different repeat sizes. <h3>Methods</h3> Patient’s skin fibroblasts were reprogrammed into iPSCs introducing four pluripotency episomal factors (SOX2, KLF4, c-MYC AND OCT4) by virus-free protocol. All iPS clones that show an uniform flat morphology were characterised for their stemness and pluripotency, both in vitro through embryoid bodies formation and in vivo through teratoma formation assay. A new protocol was optimised for differentiation of iPCs derived embryoid bodies expressing all the three germ layers (ectoderm, mesoderm and endoderm) in neurospheres of Neuronal Precursor Cells (NPCs) (Vescovi <i>et al</i>., 1999). We may obtain a neural population of astrocytes, oligodendrocytes and neuron cells by spontaneous differentiation of neurospheres in particular conditions. <h3>Results</h3> We have now obtained skin biopsies from 20 mutation positive subjects (from pre- to advanced HD stages) and five controls, at IRCCS Casa Sollievo della Sofferenza, Mendel Institute of Human Genetics, based in Rome. As first step, we got samples from subjects carrying borderline (ie 36–40 CAG) and very high (over 60) repeats. <h3>Conclusion</h3> We expect this model will allow us to highlight polyQ dependent changes in neural function and differentiation, in vitro.
Enterohemorrhagic Escherichia coli O157:H7 Survival in an In Vitro Model of the Human Large Intestine and Interactions with Probiotic Yeasts and Resident Microbiota (2012)

This is the first report on the fate of enterohemorrhagic Escherichia coli O157:H7 in simulated human colonic conditions. The pathogen was progressively eliminated from the bioreactor and did not modify the major populations of resident microbiota. The coadministration of the Saccharomyces cerevisiae CNCM I-3856 probiotic strain led to a significant increase in acetate production but did not reduce pathogen viability.
Supplementary Figure S3 from A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells (2023)

&lt;p&gt;Supplementary Figure S3. MS/MS mass spectra of tryptic peptides from RI used to identify phosphorylation sites. Biotinylated RI was produced in HEK293T cells and purified with RNase A-affinity chromatography. Purified RI was digested with trypsin, and the ensuing peptides were analyzed to identify phosphorylation sites. Five sites were identified: Thr81, Ser177, Ser289, Ser382, and Ser405.&lt;/p&gt;