gebhart/patrepeval huggingface dataset:
6G Connectivity in Dense Indoor Environments using Beamforming and Frequency Allocation over IEEE 802.11ad (2021)

The upcoming 6G network is expected to support high data rate services combining the requirements of the 5G enhanced mobile broadband (eMBB) and ultra-reliable and low-latency communications (URLLC) use cases, typically called mobile broadband reliable low latency communication (MBR-LLC). In addition, a large proliferation of extended reality (XR) services, encompassing augmented, mixed, and virtual reality (AR/MR/VR), is expected. On the other hand, the IEEE 802.11ad standard uses millimeter wave (mmWave) communications to provide data rates up to 6.76 Gbps, and supports six channels. This paper investigates the use of IEEE 802.11ad for indoor environments with high density of users. To provide high data rates to each user and avoid collisions over a single channel, we propose the use of beamforming using massive antenna arrays, coupled with a frequency allocation scheme for IEEE 802.11ad. Simulation results show that the proposed approach leads to high rates with limited interference in an indoor environment.
Conversational greeting detection using captioning on head worn displays versus smartphones (2020)

People who are deaf and hard of hearing often have difficulty realizing when someone is attempting to get their attention, especially when mobile. Speech recognition coupled with a head-worn display (HWD) may aid in awareness of when someone calls the user's name. As our intended users are often oversubscribed with experiments, we chose to test non-deaf and hard of hearing subjects while refining our procedures. Preliminary findings from three hearing participants wearing sound masking headphones and performing a mobile task suggest that a HWD display may be faster than, and preferred to, a smartphone for displaying captions for attending to one's name being called.
Computational Simulation of Redox Reactions within a Metal Electrospray Emitter (1999)

A computational simulation of the oxidation of chemical species inside a metal emitter electrospray ion source, in the context of electrospray mass spectrometry (ES-MS), has been developed. The analysis code employs a boundary integral method for the solution of the Laplace equation for the electric potential and current and incorporates standard activation and concentration polarization functions for the redox-active species in the system to define the boundary conditions. This paper provides a demonstration of the capability of this simulation method. Due to the approximate nature of some of the input data, and certain simplifying assumptions, the present results must be considered semiquantitative. The specific system modeled consisted of a 100-μm-i.d., inert metal capillary ES emitter and a spray solution composed of an analyte dissolved in CH(3)CN/H(2)O (90/10 v/v). Variable parameters included the concentration (i.e., 5.0, 10, 20, and 50 μM) of the easily oxidized analyte ferrocene (Fc, dicyclopentadienyl iron) in the solution, and solution conductivities of 1.9, 3.8, and 7.6 × 10(-)(7) Ω(-)(1)/cm, with an operational flow rate of 5.0 μL/min and ES currents on the order of 0.05 μA. Under these defined conditions, the two most prominent reactions at the emitter metal/solution interface were assumed to be H(2)O oxidation (2H(2)O = O(2) + 4H(+) + 4e(-)) and ferrocene oxidation (Fc = Fc(+) + e(-)). Using this model, it was possible to predict the interfacial potentials, as well as the current density for each of the reactions, as a function of axial position from the emitter spray tip back upstream, under the various operational conditions. The simulations show that the majority of the current from the redox reactions is generated within a 200-300-μm region near the spray tip. The lower the value of E(0) for a specific reaction, the further upstream from the tip the reaction extends.
Data from Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody (2023)

&lt;div&gt;Abstract&lt;p&gt;AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2. Although the therapeutic value of blocking Ang2 has been shown in several models of tumorigenesis and angiogenesis, the potential benefit of Ang1 antagonism is less clear. To investigate the consequences of Ang1 neutralization, we have developed potent and selective peptibodies that inhibit the interaction between Ang1 and its receptor, Tie2. Although selective Ang1 antagonism has no independent effect in models of angiogenesis-associated diseases (cancer and diabetic retinopathy), it induces ovarian atrophy in normal juvenile rats and inhibits ovarian follicular angiogenesis in a hormone-induced ovulation model. Surprisingly, the activity of Ang1 inhibitors seems to be unmasked in some disease models when combined with Ang2 inhibitors, even in the context of concurrent vascular endothelial growth factor inhibition. Dual inhibition of Ang1 and Ang2 using AMG 386 or a combination of Ang1- and Ang2-selective peptibodies cooperatively suppresses tumor xenograft growth and ovarian follicular angiogenesis; however, Ang1 inhibition fails to augment the suppressive effect of Ang2 inhibition on tumor endothelial cell proliferation, corneal angiogenesis, and oxygen-induced retinal angiogenesis. In no case was Ang1 inhibition shown to (&lt;i&gt;a&lt;/i&gt;) confer superior activity to Ang2 inhibition or dual Ang1/2 inhibition or (&lt;i&gt;b&lt;/i&gt;) antagonize the efficacy of Ang2 inhibition. These results imply that Ang1 plays a context-dependent role in promoting postnatal angiogenesis and that dual Ang1/2 inhibition is superior to selective Ang2 inhibition for suppression of angiogenesis in some postnatal settings. Mol Cancer Ther; 9(10); 2641–51. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
VNF modeling towards the cloud-RAN implementation (2017)

We address in this paper the problem of modeling Virtual Network Functions (VNFs) in order to devise execution principles. We specifically represent a VNF as a chain of sub-functions or micro-services and investigate its processing on a multi-core platform. Instead of reserving dedicated resources to a VNF, we specifically examine the gain that can be obtained by resource pooling, namely a pool of cores which is shared by active VNFs. The driving use case of this study is the virtualization and the cloudification of Radio Access Network functions, in particular Base Band Unit (BBU) functions. We validate this approach by simulation and show that an adequate threading model can reduce the VNF runtime. Obtained results open the door towards the Cloud-RAN implementation since some BBU tasks might be hosted in geographically distant data centers.
Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation (2023)

Irradiation can be an effective treatment for ovarian cancer, but its use is limited by intestinal toxicity. Thus, strategies to mitigate toxicity are important and can revitalize the current standard of care. We previously established that LR-IL-22 protects the intestine from WAI. We now hypothesize that LR-IFN-β is an effective radiation protector and mitigator and is rapidly cleared from the digestive tract, making it an option for intestinal radioprotection. We report that the gavage of LR-IFN-β during WAI provides improved intestinal barrier integrity and significantly preserves the numbers of Lgr5+GFP+ intestinal stem cells, improving survival. The rapid clearance of the genetically engineered probiotic from the digestive tract renders it a safe and feasible radiation mitigator. Therefore, the above genetically engineered probiotic is both a feasible and effective radiation mitigator that could potentially revolutionize the management of OC patients. Furthermore, the subsequent addition of platinum/taxane-based chemotherapy to the combination of WAI and LR-IFN-β should reduce tumor volume while protecting the intestine and should improve the overall survival in OC patients.
Large scale relative protein ligand binding affinities using non-equilibrium alchemy (2019)

Ligand binding affinity calculations based on molecular dynamics (MD) simulations and non-physical (alchemical) thermodynamic cycles have shown great promise for structure-based drug design. However, their broad uptake and impact is held back by the notoriously complex setup of the calculations. Only a few tools other than the free energy perturbation approach by Schrödinger Inc. (referred to as FEP+) currently enable end-to-end application. Here, we present for the first time an approach based on the open-source software pmx that allows to easily set up and run alchemical calculations for diverse sets of small molecules using the GROMACS MD engine. The method relies on theoretically rigorous non-equilibrium thermodynamic integration (TI) foundations, and its flexibility allows calculations with multiple force fields. In this study, results from the Amber and Charmm force fields were combined to yield a consensus outcome performing on par with the commercial FEP+ approach. A large dataset of 482 perturbations from 13 different protein-ligand datasets led to an average unsigned error (AUE) of 3.64 ± 0.14 kJ mol<sup>-1</sup>, equivalent to Schrödinger's FEP+ AUE of 3.66 ± 0.14 kJ mol<sup>-1</sup>. For the first time, a setup is presented for overall high precision and high accuracy relative protein-ligand alchemical free energy calculations based on open-source software.
Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury (2020)

Altered neuronal Ca<sup>2+</sup> homeostasis and mitochondrial dysfunction play a central role in the pathogenesis of traumatic brain injury (TBI). R-Phenibut ((3R)-phenyl-4-aminobutyric acid) is an antagonist of the <i>α</i> <sub>2</sub> <i>δ</i> subunit of voltage-dependent calcium channels (VDCC) and an agonist of gamma-aminobutyric acid B (GABA-B) receptors. The aim of this study was to evaluate the potential therapeutic effects of R-phenibut following the lateral fluid percussion injury (latFPI) model of TBI in mice and the impact of R- and S-phenibut on mitochondrial functionality <i>in vitro</i>. By determining the bioavailability of R-phenibut in the mouse brain tissue and plasma, we found that R-phenibut (50 mg/kg) reached the brain tissue 15 min after intraperitoneal (i.p.) and peroral (p.o.) injections. The maximal concentration of R-phenibut in the brain tissues was 0.6 <i>μ</i>g/g and 0.2 <i>μ</i>g/g tissue after i.p. and p.o. administration, respectively. Male Swiss-Webster mice received i.p. injections of R-phenibut at doses of 10 or 50 mg/kg 2 h after TBI and then once daily for 7 days. R-Phenibut treatment at the dose of 50 mg/kg significantly ameliorated functional deficits after TBI on postinjury days 1, 4, and 7. Seven days after TBI, the number of Nissl-stained dark neurons (N-DNs) and interleukin-1beta (IL-1<i>β</i>) expression in the cerebral neocortex in the area of cortical impact were reduced. Moreover, the addition of R- and S-phenibut at a concentration of 0.5 <i>μ</i>g/ml inhibited calcium-induced mitochondrial swelling in the brain homogenate and prevented anoxia-reoxygenation-induced increases in mitochondrial H<sub>2</sub>O<sub>2</sub> production and the H<sub>2</sub>O<sub>2</sub>/O ratio. Taken together, these results suggest that R-phenibut could serve as a neuroprotective agent and promising drug candidate for treating TBI.
New Low Temperature Processing for Boron Carbide/Aluminum Based Composite Armor (1990)

The developed Boron Carbide/Aluminum based materials are a promising alternative for the use in lightweight armor application. The advantage of B4C/ A1 composite over the traditional metal armor is its ballistic limit of 80 to 90% of that for hot pressed B4C, thus similar to ceramics such as A1N or SiC. The advantage of B4C/A1 over monolithic ceramic armor is its higher toughness. The ballistic efficiency of B4C materials, relative to hot-pressed boron carbide, was found to be directly related to the initial boron carbide content, the B-C-A1 phases formed in situ, and their continuity. The highest improvement of ballistic efficiency was associated with increasing contents of B4C and A1B2 in the system. The Rapid Omnidirectional Compaction process is a suitable technique to produce nearly dense B4C/A1 cermet at the low temperature. Dense, but soft, cermets can be near-net shaped and then changed into hard, ceramic- like structure through heat-treatment. Mechanical properties of B4C/A1 cermet depend mostly on the concentration and continuity of the boron carbide phase. Colloidal processing and post densification heat-treatment can be used to further modify properties for the application at hand. Keywords: Lightweight armor, Cermets, Rapid Omnidirectional Compaction, Dispersion, Aluminum alloys, Boron carbide.
Association between anthropometric markers of adiposity, adipokines and vitamin D levels (2022)

Inverse association between serum levels of vitamin D and obesity has been pointed out in several studies. Our aim was to identify to the associations between vitamin D levels and a large panel of anthropometric markers and adipokines. Cross-sectional study including 6485 participants. Anthropometric markers included body mass index (BMI), % body fat, waist, waist-to-hip (WHR), waist-to-height (WHtR), conicity index, body roundness index (BRI) and a body shape index (ABSI). 55.7% of women and 60.1% of men presented with vitamin D deficiency. Vitamin D levels were negatively associated with most anthropometric markers, with correlation coefficients ranging between -0.017 (ABSI) and -0.192 (BMI) in women and between -0.026 (weight) and -0.130 (% body fat) in men. Vitamin D levels were inversely associated with leptin levels in both sexes and positively associated with adiponectin levels in women only. The likelihood of vitamin D deficiency increased with increasing adiposity levels, except for ABSI (women) and BMI (men). Total body fat, rather than localized or unevenly distributed body fat, is the adiposity marker most associated with decreased vitamin D levels. Monitoring vitamin D levels in people with overweight/obesity is essential.
Nucleotide and amino acid sequence of pap-gene (pediocin AcH production) in Pediococcus acidilactici H (1992)

N-terminal analysis of purified pediocin AcH produced a partial sequence of 23 amino acids. This sequence matched perfectly with a segment of 23 amino acids in a 62 amino acid molecule generated from the 186 nucleotide sequence open reading frame in a Hind III fragment in pSMB74 encoding pap-gene (pediocin AcH production). It is suggested that the molecule is translated as inactive prepediocin AcH of 62 amino acids. Then through enzymatic modifications the leader segment of 18 amino acids is removed from the NH2-terminal. The remaining segment of 44 amino acids is active pediocin AcH of 4628 M(r).
The therapeutic potential of agents acting via purine receptors (1998)

A host of physiological processes associated with the cardiovascular (CV) system, central nervous system (CNS), and a variety of other organ systems and tissues are regulated by agents, primarily adenosine (ado) and adenosine triphosphate (ATP), that act via cell-surface purine receptors. These receptors have therefore been the focus of a variety of programmes directed at the discovery and development of new therapeutic agents, most notably for the treatment of disorders of the CV system. Currently, only a handful of agents, including ado, theophylline, dipyridamole, and ticlopidine, are approved for clinical use. A variety of new agents intended for use in CV disease, disorders of the CNS, such as Parkinson's disease, treatment of pain, inflammatory disorders, and diverse other pathophysiological conditions are in clinical development. Historically, ado receptors have been the primary target. Recent research efforts have begun to examine alternative strategies including agents that modulate endogenous levels of extracellular ado and agents that act via P(2) receptors.
E204 Velocity profile measurements in a pipe flow using ultrasonic pulse Doppler method (2008)

In order to improve thermal efficiency and optimize plant operation at electric power plants, ultrasonic pulse Doppler method is being developed to attain the high accuracy in flow rate measurements. Ultrasound waves are emitted into fluid from ultrasonic transducer mounted on the outer surface of a pipe. Waves are bounced back at the surface of ultrasound reflectors flowing in fluid. By detecting Doppler shift frequency of those waves, velocity profiles along the ultrasound beam path can be obtained. Integration of those instantaneous velocity profiles gives us the flow rate in a pipe. In this report, the series of velocity profile measurements are summarized with field tests at an actual power plant for the downstream of an elbow with micro bubbles generated for ultrasonic reflectors.
Faculty Opinions recommendation of Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974). (2008)

Read the full review for this Faculty Opinions recommended article: Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation (2007)

Stage III nonsmall cell lung cancer is primarily treated with combined chemotherapy and radiation therapy. Relapses for progression of disease within irradiated sites remains a primary pattern of failure. To evaluate the interaction between histone deacetylase inhibitors and irradiation in nonsmall cell lung cancer, we studied NVP-LAQ824 in mouse models of human lung cancer. Colony formation assays were performed to determine whether LAQ824 sensitized nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. LAQ824 reduced clonogenic survival of the H23 and H460 cell lines five-fold compared with controls and four-fold compared with either agent alone (P<0.001). Western blot analysis of caspase cleavage, microscopic analysis of nuclei and Annexin-fluorescein isothiocyanate/propidium iodide flow cytometry assays showed that LAQ824 enhanced radiation-induced apoptosis and attenuated mitosis (P<0.001). Immunostaining for gamma-H2AX nuclear foci was performed to determine the effect of LAQ824 on radiation-induced DNA double-strand breaks. Combined modality treatment delayed the resolution of gamma-H2AX foci with over 30% of cells staining positive 6 h after treatment versus approximately 5 and 3% in cells treated with LAQ824 or radiation alone (P<0.001). Additionally, an in-vivo xenograft model was utilized to study the effects of fractioned irradiation and LAQ824 on tumor growth. Fractioned irradiation and LAQ824 delayed tumor growth by 19 days versus 7 and 4 days for treatment with LAQ824 and radiation alone. This study shows the effectiveness of histone deacetylase inhibitors to enhance the cytotoxic effects of radiation by attenuating DNA repair and inducing apoptosis in human nonsmall cell lung cancer.
Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network (2021)

Ceramides are composed of a sphingosine and a single fatty acid connected by an amide linkage. As one of the major classes of biologically active lipids, ceramides and their upstream and downstream metabolites have been implicated in several pathological conditions including cancer, neurodegeneration, diabetes, microbial pathogenesis, obesity, and inflammation. Consequently, tremendous efforts have been devoted to deciphering the dynamics of metabolic pathways involved in ceramide biosynthesis. Given that several distinct enzymes can produce ceramide, different enzyme targets have been pursued depending on the underlying disease mechanism. The main objective of this review is to provide a comprehensive overview of small molecule inhibitors reported to date for each of these ceramide-producing enzymes from a medicinal chemistry perspective.
Photocatalytic Degradation of Self-Assembled Monolayers Anchored at the Vicinity of Titanium Dioxide Domains (2002)

Abstract In order to study the photodegradation of molecules located at the vicinity of a titanium dioxide photocatalyst, a well-defined structure comprised of alternating micro-stripes of TiO
The Bacterial Actin MamK (2012)

It is now recognized that actin-like proteins are widespread in bacteria and, in contrast to eukaryotic actins, are highly diverse in sequence and function. The bacterial actin, MamK, represents a clade, primarily found in magnetotactic bacteria, that is involved in the proper organization of subcellular organelles, termed magnetosomes. We have previously shown that MamK from Magnetospirillum magneticum AMB-1 (AMB-1) forms dynamic filaments in vivo. To gain further insights into the molecular mechanisms that underlie MamK dynamics and function, we have now studied the in vitro properties of MamK. We demonstrate that MamK is an ATPase that, in the presence of ATP, assembles rapidly into filaments that disassemble once ATP is depleted. The mutation of a conserved active site residue (E143A) abolishes ATPase activity of MamK but not its ability to form filaments. Filament disassembly depends on both ATPase activity and potassium levels, the latter of which results in the organization of MamK filaments into bundles. These data are consistent with observations indicating that accessory factors are required to promote filament disassembly and for spatial organization of filaments in vivo. We also used cryo-electron microscopy to obtain a high resolution structure of MamK filaments. MamK adopts a two-stranded helical filament architecture, but unlike eukaryotic actin and other actin-like filaments, subunits in MamK strands are unstaggered giving rise to a unique filament architecture. Beyond extending our knowledge of the properties and function of MamK in magnetotactic bacteria, this study emphasizes the functional and structural diversity of bacterial actins in general.
A single-chip, functional tester for VLSI circuits (1990)

A single-chip functional tester for VLSI circuits that integrates the vector memory, the error memory, a decompressor, and 16 sets of independently controlled pin electronics on a 9.0*9.4-mm chip is described. The device contains over 200 K transistors and is fabricated using a 1.6- mu m CMOS technology. The integrated pin electronics support a per-pin tester architecture, allowing the transitions for each pin to be independently adjusted to better than 1 ns. The chip dissipates less than 0.75 W running at 25 M vectors/s. By integrating all tester functions on a single chip, it is possible to build all extremely compact tester. A 256-pin tester requires only 16 chips. This size makes it possible to reduce the length of the transmission line between the device under test and the tester to under 10 cm, minimizing signal reflections and enabling the delivery of high-fidelity waveforms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>