gebhart/patrepeval huggingface dataset:
170K-pixel CCD Camera Module for Mobile Phones (2004)

We have developed a small-sized camera module for mobile phones. In the modern world of sophisticates mobile phones customers expect to be able to connect to the Net and communicate with images. First, we set the specifications of the camera module to meet market demands. Then we developed a camera which met those demands. For mobile phones a low profile camera module with high image resolution and high sensitivity are indispensable. We developed a module with a height of only 4.6 mm with compact 3.3 mm optical length lens. It is a 170, 000 pixel PIA-CCD cameras for high image quality. We ascertained that the camera had achieved high sensitivity (less than 2 lx), high SNR, and high flame rate (20 fps).
Catechols as ligands for CdSe–ZnS quantum dots (2014)

We introduce catechol-containing molecules as potential ligands for quantum dots (QD), via a ligand exchange method. Hydrophilic ligands were attached to their surface, which resulted in a successful transfer to the aqueous phase. A significant quenching effect on the luminescent properties was observed. The interaction between the QD and the catechols made it possible to sense dopamine in the nanomolar range.
B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. (1991)

Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.
Synthesis of a 68Ga-Labeled Peptoid−Peptide Hybrid for Imaging of Neurotensin Receptor Expression in Vivo (2010)

The neurotensin receptor subtype 1 (NTS1) represents an attractive molecular target for imaging various tumors. Positron emission tomography (PET) gained widespread importance due to its sensitivity. We combined the design of a metabolically stable neurotensin analogue with a (68)Ga-radiolabeling approach. The (68)Ga-labeled peptoid-peptide hybrid [(68)Ga]3 revealed high stability, specific tumor uptake (0.7%ID/g, 65 min p.i.), and advantageous biokinetics in vivo using HT29 tumor-bearing nude mice. Because of the ability to internalize into NTS1-expressing tumor cells, [(68)Ga]3 proved to be highly suitable for a reliable and practical visualization of NTS1-expressing tumors in vivo by small animal PET.
Endothelin-1-induced GLUT4 Translocation Is Mediated via Gαq/11 Protein and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes (1999)

Endothelin-1 (ET-1) can stimulate insulin-responsive glucose transporter (GLUT4) translocation in 3T3-L1 adipocytes (Wu-Wong, J. R., Berg, C. E., Wang, J., Chiou, W. J., and Fissel, B. (1999) J. Biol. Chem. 274, 8103-8110), and in the current study, we have evaluated the signaling pathway leading to this response. First, we inhibited endogenous Galpha(q/11) function by single-cell microinjection using anti-Galpha(q/11) antibody or RGS2 protein (a GTPase activating protein for Galpha(q)) followed by immunostaining to quantitate GLUT4 translocation in 3T3-L1 adipocytes. ET-1-stimulated GLUT4 translocation was markedly decreased by 70 or 75% by microinjection of Galpha(q/11) antibody or RGS2 protein, respectively. Pretreatment of cells with the Galpha(i) inhibitor (pertussis toxin) or microinjection of a Gbetagamma inhibitor (glutathione S-transferase-beta-adrenergic receptor kinase (GST-BARK)) did not inhibit ET-1-induced GLUT4 translocation, indicating that Galpha(q/11 )mediates ET-1 signaling to GLUT4 translocation. Next, we found that ET-1-induced GLUT4 translocation was inhibited by the phosphatidylinositol (PI) 3-kinase inhibitors wortmannin or LY294002, but not by the phospholipase C inhibitor U-73122. ET-1 stimulated the PI 3-kinase activity of the p110alpha subunit (5.5-fold), and microinjection of anti-p110alpha or PKC-lambda antibodies inhibited ET-stimulated GLUT4 translocation. Finally, we found that Galpha(q/11) formed immunocomplexes with the type-A endothelin receptor and the 110alpha subunit of PI 3-kinase and that ET-1 stimulation enhances tyrosine phosphorylation of Galpha(q/11). These results indicate that: 1) ET-1 signaling to GLUT4 translocation is dependent upon Galpha(q/11) and PI 3-kinase; and 2) Galpha(q/11) can transmit signals from the ET(A) receptor to the p110alpha subunit of PI 3-kinase, as does insulin, subsequently leading to GLUT4 translocation.
A 2048-channel, 125μW/ch DAC Controlling a 9,216-element Optical Phased Array Coherent Solid-State LiDAR (2023)

A CMOS driver chip for controlling an optical phased array realizing $\mathrm{a}\gt50$ meter coherent LiDAR engine has been demonstrated. Five identical 2048-channel driver chips flip onto a single silicon photonics LiDAR engine IC containing the 9,216-element optical phased array. Each voltage-mode driver cell controls an individual electro-optic phase shifter in the array and adjusts the phase shift from 0 to $2 \pi$ over 8 bits. Each driver cell has an average power of $125 \mu \mathrm{W}$ with a resolve time of $\lt400$ ns and the driver chip is capable of a system pointto-point steering time $\lt 3.8 \mu \mathrm{s}$.
Polyhedral parallel code generation for CUDA (2013)

This article addresses the compilation of a sequential program for parallel execution on a modern GPU. To this end, we present a novel source-to-source compiler called PPCG. PPCG singles out for its ability to accelerate computations from any static control loop nest, generating multiple CUDA kernels when necessary. We introduce a multilevel tiling strategy and a code generation scheme for the parallelization and locality optimization of imperfectly nested loops, managing memory and exposing concurrency according to the constraints of modern GPUs. We evaluate our algorithms and tool on the entire PolyBench suite.
High-Speed Imaging of Dusty Plasma Instabilities (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation H. Tawidian, L. Couëdel, M. Mikikian, T. Lecas, L. Boufendi, O. Vallée; High‐Speed Imaging of Dusty Plasma Instabilities. AIP Conf. Proc. 29 November 2011; 1397 (1): 445–446. https://doi.org/10.1063/1.3659885 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Stress induced metallurgical effects in Ti/TiN/AlCu/TiN metal stacks (2002)

Integrated circuits with aluminum metallization for products with high current densities need a metal stack with liner and antireflective coating (ARC) which can fulfill several requirements (e.g. low sheet resistance, high reliability, smooth surface, good adhesion, thermal stability, etc.). In this work different multilayer metal stacks are investigated and several phenomena which can be observed after thermal annealing of Ti/TiN/AlCu/TiN stacks are described and discussed. Metallurgical, electrical and mechanical properties of different layer combinations are investigated after thermal annealing and stress tests are done to compare the electromigration and life time behavior of each metal stack. For all investigated metal stacks it is shown that an interface reaction between Ti and aluminum will form TiAl3 phase. Even with very thick TiN layers on top of titanium or with only TiN liner the phase formation occurred. Explanations and models for the formation of different phenomena (hillocks, depressions and elevations), are discussed. The origin of each phenomena is stress related and assisted either by the liner material and/or the ARC layer. A qualitative model which explains the different observed layer reactions is discussed.
Central Government (1987)

It will be remembered that the Royal Commission recommended, among other things, that the Secretaries of State should be given a statutory responsibility for the efficiency of the police, but that they should not be given powers of direction over operational matters on the grounds that this would be inappropriate and that it was desirable that the police should be seen to be responsible for the enforcement of law.1 Despite this recommendation, the government did not see fit to introduce that statutory responsibility in either the Police Act 1964 or the Police (Scotland) Act 1967; most of the other recommendations in this area were accepted and introduced, with the major exception that a Chief Inspector of Constabulary for Great Britain was not appointed but a Chief Inspector for England and Wales and another for Scotland were introduced.
Development of a new in-laboratory XAFS apparatus based on new concept (2001)

In a conventional in-laboratory XAFS apparatus using conventional X-ray source, sealed tube or rotating anode, has been used. In which the X-ray source is fixed and the sample is moved (translated and rotated). Hence it has been difficult or required a complex method in order to put a heavy element, such as a cryogenic cooler, high temperature furnace and an in-situ reacting cell, at a sample position. Nowadays, there is a strong demand for obtaining dynamic information of a sample and in-situ observation becomes almost unavoidable. We have developed a compact X-ray tube and a new goniometer on which X-ray source is moved and monochromatic X-ray comes out of goniometer is fixed. Therefore it becomes easier to put a various cell at a sample position.
Supplementary file 1 from Identification of Existing Drugs That Effectively Target <i>NTRK1</i> and <i>ROS1</i> Rearrangements in Lung Cancer (2023)

&lt;p&gt;Contents of the Dana-Farber Targeted Therapy Library and raw data&lt;/p&gt;
Immune Reconstitution in Patients with HIV Infection (2002)

The peripheral T cell pool is damaged by HIV-1 infection and can be regenerated by production of new T lymphocytes either from the thymus or from proliferation of post-thymic T cells. A critical question for AIDS patients is whether treatment with antiretroviral drugs can restore the capability to produce new T lymphocytes. The development of a new assay of thymus function in adults (the measurement of T cell receptor excision circles, TRECs), and studies of thymus biopsies in untreated and treated HIV-1-infected patients, have suggested that in select patients the thymus can regenerate on antiretroviral therapy. New strategies to overcome the thymic atrophy of aging are needed to improve thymic function in the majority of AIDS patients.
Semiautonomous Mapping System (2003)

There is an emerging global market for free swimming undersea robots that are reliable, increase productivity, provide high quality data, and are easy to program and operate. To gain acceptance these robots have to be inexpensive to own and versatile. This paper describes the Semiautonomous Mapping System (SAMS) a UUV designed to survey the ocean from a depth of 10 m to a depth of 6 km. SAMS was developed under a cooperative program involving the Naval Oceanographic Office, the Office of Naval Research, and the Woods Hole Oceanographic Institution (WHOI). The system, including launch and recovery gear, is land, sea, and air shippable in one standard 2.4 by 6 meter ISO container. The system is operable from T-AGS-60 ships and other Oceanographic vessels in sea states up to those generated by Beaufort Scale six winds. The system is operated, maintained, and repaired at sea by trained technician level personnel. SAMS is based on the REMUS UUV, which was also developed at WHOI.
Visualizing Quantum Dots in Biological Samples Using Silver Staining (2009)

Quantum dot (QD) based contrast agents are currently being developed as probes for bioimaging and as vehicles for drug delivery. The ability to detect QDs, regardless of fluorescence brightness, in cells, tissues, and organs is imperative to their development. Traditional methods used to visualize the distribution of QDs in biological samples mainly rely on fluorescence imaging, which does not account for optically degenerate QDs as a result of oxidative quenching within the biological environment. Here, we demonstrate the use of silver staining for directly visualizing the distribution of QDs within biological samples under bright field microscopy. This strategy involves silver deposition onto the surface of QDs upon reduction by hydroquinone, effectively amplifying the size of QDs until visible for detection. The method can be used to detect non-fluorescent QDs and is fast, simple, and inexpensive.
Acute Kidney Injury Increases Risk of ESRD among Elderly (2008)

Risk for ESRD among elderly patients with acute kidney injury (AKI) has not been studied in a large, representative sample. This study aimed to determine incidence rates and hazard ratios for developing ESRD in elderly individuals, with and without chronic kidney disease (CKD), who had AKI. In the 2000 5% random sample of Medicare beneficiaries, clinical conditions were identified using Medicare claims; ESRD treatment information was obtained from ESRD registration during 2 yr of follow-up. Our cohort of 233,803 patients were hospitalized in 2000, were aged > or = 67 yr on discharge, did not have previous ESRD or AKI, and were Medicare-entitled for > or = 2 yr before discharge. In this cohort, 3.1% survived to discharge with a diagnosis of AKI, and 5.3 per 1000 developed ESRD. Among patients who received treatment for ESRD, 25.2% had a previous history of AKI. After adjustment for age, gender, race, diabetes, and hypertension, the hazard ratio for developing ESRD was 41.2 (95% confidence interval [CI] 34.6 to 49.1) for patients with AKI and CKD relative to those without kidney disease, 13.0 (95% CI 10.6 to 16.0) for patients with AKI and without previous CKD, and 8.4 (95% CI 7.4 to 9.6) for patients with CKD and without AKI. In summary, elderly individuals with AKI, particularly those with previously diagnosed CKD, are at significantly increased risk for ESRD, suggesting that episodes of AKI may accelerate progression of renal disease.
Constraints on Nucleon Decay via Invisible Modes from the Sudbury Neutrino Observatory (2004)

Data from the Sudbury Neutrino Observatory have been used to constrain the lifetime for nucleon decay to "invisible" modes, such as n-->3nu. The analysis was based on a search for gamma rays from the deexcitation of the residual nucleus that would result from the disappearance of either a proton or neutron from 16O. A limit of tau(inv)>2 x 10(29) yr is obtained at 90% confidence for either neutron- or proton-decay modes. This is about an order of magnitude more stringent than previous constraints on invisible proton-decay modes and 400 times more stringent than similar neutron modes.
Sudoku Texture Classification (2016)

One of the most successful features for texture recognition is the Local Binary Pattern. The LBP is the 8 digit binary number created by comparing the value of a central pixel with its 8 neighbours where 1s and 0s are assigned when respectively the central pixel is larger or smaller than its neighbour. This pattern is bit shifted circularly to its maximum value to obtain rotational invariance. Comparing histograms of LBPs provides leading texture recognition. In our research, we rank the center pixel with all its 8 neighbours. Each pixel is substituted by a 3x3 grid where the numbers one through nine appear once and correspond to the rank of the underlying pixel values (of the local 3x3 neighbourhood) i.e. an input image is transformed to look like a Sudoku grid. Then, we read out the ranks clockwise starting with the right-most rank and appending the central pixel to the end, we then rotate to the maximum value (so achieving rotational invariance). Each 9 digit number is non-linearly mapped to the interval [0,1] so that the overall dataset histogram has a uniform distribution. By comparing the histograms of our Sudoku rank features, we observe a significant increase in recognition performance for the Outex and Curet benchmark datasets.
Endoscopic Ultrasound (EUS) Guided Pancreatic Fluid Aspiration for DNA Analysis of KRAS and GNAS Mutations for the Evaluation of Pancreatic Cystic Neoplasia (2012)

Purpose: Discriminating benign from premalignant cysts of the pancreas is limited by the performance of cyst fluid aspirate and cytology. The presence of KRAS mutations in cyst fluid has been reported to increase the yield of cyst fluid aspirate for the presence of neoplastic cysts. Recently, mutations in GNAS have been found to have an oncogenic role in intraductal papillary mucinous neoplasms (IPMN) through promotion of adenyl cyclase activity and cAMP levels. Our aim was to evaluate whether analysis of cyst fluid DNA obtained by EUS for GNAS mutations can enhance the preoperative diagnosis of neoplastic pancreatic cysts. Methods: Endoscopic ultrasound-guided pancreatic cyst aspirates were collected during a 24-month period and investigated for cytology, carcinoembryonic antigen (CEA) level, and molecular analysis. KRAS and GNAS point mutations were detected by dideoxy chain termination sequencing (Applied Biosystems) of extracted DNA (qiagen) from cyst fluid. The cyst fluid analysis was compared to the final surgical pathology or cytology. Results: We identified 23 patients (11 male, mean age = 68.2 ± 13.8 [SD] years) with pancreatic cysts who underwent EUS-guided cyst aspiration. The mean cyst diameter was 2.3 cm (range 1-8 cm). Cysts were located in the head (n=10), body (n=8), and tail (n=5) of the pancreas. The cohort consisted of four serous cystadenomas (SCA), three mucinous cyst neoplasms (MCN), one pseudocyst, five solid-cystic adenocarcinoma (PDA), two solid-cystic endocrine neoplasms, one lymphoepithelial cyst, and seven IPMNs. The mean cyst fluid CEA levels in IPMNs was 3,895 ng/mL (range 22-24,747); 3/7 patients with IPMN had CEA levels <192 ng/mL. Mutations in KRAS were present in 5/7 (71%) IPMNs; LOH was demonstrated in three of these. Three of seven (43%) IPMNs carried a mutation in GNAS, all of which harbored degrees of dysplasia. The mutations in GNAS occurred at codon 201. All IPMNs carried a mutation in at least one of the two oncogenes. No mutations were identified in the SCA, in contrast to the IPMNs (p<0.01). GNAS mutations were not identified in any of the MCNs or PDA (p<0.005 when compared to IPMNs), although KRAS mutations were found in 1/3 (33%) of MCNs and 3/5 (60%) of PDAs. Cyst fluid CEA >192 ng/mL had a sensitivity of 57% to predict the presence of an IPMN. The sensitivity of KRAS mutation in cyst fluid was 71% for the diagnosis of IPMN, but with the addition of GNAS mutations, all IPMNs were identified (sensitivity = 100%, p<0.05). Conclusion: The presence of GNAS in combination with KRAS in pancreatic cystic fluid improves the sensitivity for diagnosis of IPMN when compared to CEA or KRAS alone. This demonstrates the feasibility of GNAS analysis from pancreatic cyst fluid obtained by EUS guided aspiration.
Why Do They Leave: Modeling Participation in Online Depression Forums (2016)

Farig Sadeque, Ted Pedersen, Thamar Solorio, Prasha Shrestha, Nicolas Rey-Villamizar, Steven Bethard. Proceedings of the Fourth International Workshop on Natural Language Processing for Social Media. 2016.
Isolation and characterization ofHelicobacter suisfrom human stomach (2021)

<i>Helicobacter suis</i>, a bacterial species naturally hosted by pigs, can colonize the human stomach in the context of gastric diseases such as gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Because <i>H. suis</i> has been successfully isolated from pigs, but not from humans, evidence linking human <i>H. suis</i> infection to gastric diseases has remained incomplete. In this study, we successfully in vitro cultured <i>H. suis</i> directly from human stomachs. Unlike <i>Helicobacter pylori</i>, the viability of <i>H. suis</i> decreases significantly on neutral pH; therefore, we achieved this using a low-pH medium for transport of gastric biopsies. Ultimately, we isolated <i>H. suis</i> from three patients with gastric diseases, including gastric MALT lymphoma. Successful eradication of <i>H. suis</i> yielded significant improvements in endoscopic and histopathological findings. Oral infection of mice with <i>H. suis</i> clinical isolates elicited gastric and systemic inflammatory responses; in addition, progression of gastric mucosal metaplasia was observed 4 mo postinfection. Because <i>H. suis</i> could be isolated from the stomachs of infected mice, our findings satisfied Koch's postulates. Although further prospective clinical studies are needed, <i>H. suis</i>, like <i>H. pylori</i>, is likely a gastric pathogen in humans. Furthermore, comparative genomic analysis of <i>H. suis</i> using complete genomes of clinical isolates revealed that the genome of each <i>H. suis</i> isolate contained highly plastic genomic regions encoding putative strain-specific virulence factors, including type IV secretion system-associated genes, and that <i>H. suis</i> isolates from humans and pigs were genetically very similar, suggesting possible pig-to-human transmission.
Quantitative 3D-Gefügeanalyse — Stereologie oder Tomographie (2008)

Kurzfassung In der Materialforschung ist die dreidimensionale Ausprägung des Gefüges der Schlüssel zum Verständnis des Zusammenhanges zu den Herstellparametern einerseits und den Eigenschaften des Werkstoffs andererseits. Die prinzipielle Frage ist, ob es unbedingt nötig ist, alle Gefügemorphologien in 3D zu untersuchen, oder ob es ausreicht, bei den Gefügen die viel praktischere 2D-Bildanalyse zu nutzen und die 3D-Parameter nach stereologischen Beziehungen zu berechnen. Erwartungsgemäß gibt es bei der Vielfalt der Gefüge und den entsprechend komplexen Zusammenhängen keine generelle und einfache Antwort darauf. In diesem Beitrag wird am Beispiel der Korngrößenbeschreibung und damit verbundener Kennzahlen reflektiert, wann die 2D-Bildanalyse mit stereologischen Schätzungen zur 3D-Situation praktikable Ergebnisse liefert und wann die Gefügetomographie unbedingt nötig ist, um geeignete Informationen über das räumliche Gefüge zu gewinnen. Ausgehend von den bildfeldbezogenen vier Grundparametern des Gefüges wird dazu die Korngrößenbestimmung unter der Annahme von Kornformen mit zunehmender Komplexität (Kugel — äquiaxiale Polyeder — nichtäquiaxiale Polyeder — nichtkonvexe Kornformen) diskutiert. Es wird gezeigt, dass bei nicht konvexen unregelmäßigen Kornformen die 3D-Charakterisierung für sichere Klassifikationen und auch die Quantifizierung räumlicher Kenngrößen wie der Konnektivität oder der Teilchenzahl im Volumen unverzichtbar ist.
Using Arabidopsis-Related Model Species (ARMS): Growth, Genetic Transformation, and Comparative Genomics (2013)

The Arabidopsis-related model species (ARMS) Thellungiella salsuginea and Thellungiella parvula have generated broad interest in salt stress research. While general growth characteristics of these species are similar to Arabidopsis, some aspects of their life cycle require particular attention in order to obtain healthy plants, with a large production of seeds in a relatively short time. This chapter describes basic procedures for growth, maintenance, and Agrobacterium-mediated transformation of ARMS. Where appropriate, differences in requirements between Thellungiella spp. and Arabidopsis are highlighted, along with basic growth requirements of other less studied candidate model species. Current techniques for comparative genomics analysis between Arabidopsis and ARMS are also described in detail.