gebhart/patrepeval huggingface dataset:
Aluminium‐27 NMR studies of aluminiumporphyrins (1991)

Abstract Aluminium‐27 NMR has been employed to study several different aluminiumporphyrins based on (5, 10, 15, 20‐tetraphenyl)porphyrin (TPPH 2 ). The aluminiumporphyrins were formed by reacting a stoichiometric amount of trialkylaluminium with TPPH 2 to yield TPPAl‐R. The resulting aluminiumporphyrin was modified by adding a stoichiometric amount of various carboxylic acids to form aluminiumporphyrin carboxylates that had varying steric and electronic effects on the macrocycle.
Reliability analysis of the low resistance state stability of Ge0.3Se0.7 based solid electrolyte nonvolatile memory cells (2009)

We report on the low resistance state (LRS) stability analysis of Ge0.3Se0.7 based solid electrolyte nonvolatile memory cells under elevated temperature and bias current stress conditions. The activation energy was found to be about 1.02 eV, which is comparable to that of an electromigration-induced failure process. Experimental results also show that there is trade-off between the LRS stability and the thickness of Ge0.3Se0.7 layer.
ColO-RAN: Developing Machine Learning-Based xApps for Open RAN Closed-Loop Control on Programmable Experimental Platforms (2022)

Cellular networks are undergoing a radical transformation toward disaggregated, fully virtualized, and programmable architectures with increasingly heterogeneous devices and applications. In this context, the open architecture standardized by the O-RAN Alliance enables algorithmic and hardware-independent Radio Access Network (RAN) adaptation through closed-loop control. O-RAN introduces Machine Learning (ML)-based network control and automation algorithms as so-called <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">xApps</i> running on RAN Intelligent Controllers . However, in spite of the new opportunities brought about by the Open RAN, advances in ML-based network automation have been slow, mainly because of the unavailability of large-scale datasets and experimental testing infrastructure. This slows down the development and widespread adoption of Deep Reinforcement Learning (DRL) agents on real networks, delaying progress in intelligent and autonomous RAN control. In this paper, we address these challenges by discussing insights and practical solutions for the design, training, testing, and experimental evaluation of DRL-based closed-loop control in the Open RAN. To this end, we introduce ColO-RAN, the first publicly-available large-scale O-RAN testing framework with software-defined radios-in-the-loop. Building on the scale and computational capabilities of the Colosseum wireless network emulator, ColO-RAN enables ML research at scale using O-RAN components, programmable base stations, and a “wireless data factory.” Specifically, we design and develop three exemplary xApps for DRL-based control of RAN slicing, scheduling and online model training, and evaluate their performance on a cellular network with 7 softwarized base stations and 42 users. Finally, we showcase the portability of ColO-RAN to different platforms by deploying it on Arena, an indoor programmable testbed. The lessons learned from the ColO-RAN implementation and the extensive results from our first-of-its-kind large-scale evaluation highlight the importance of experimental frameworks for the development of end-to-end intelligent RAN control pipelines, from data analysis to the design and testing of DRL agents. They also provide insights on the challenges and benefits of DRL-based adaptive control, and on the trade-offs associated to training on a live RAN. ColO-RAN and the collected large-scale dataset are publicly available to the research community.
A One‐Step Process for the Antimicrobial Finishing of Textiles with Crystalline TiO2 Nanoparticles (2012)

Titanium oxide (TiO(2)) nanoparticles (NPs) in their two forms, anatase and rutile, were synthesized and deposited onto the surface of cotton fabrics by using ultrasonic irradiation. The structure and morphology of the nanoparticles were analyzed by using characterization methods such as XRD, TEM, STEM, and EDS. The antimicrobial activities of the TiO(2)-cotton composites were tested against Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) strains, as well as against Candida albicans. Significant antimicrobial effect was observed, mainly against Staphylococcus aureus. In addition, the combination of visible light and TiO(2) NPs showed enhanced antimicrobial activity.
The gut microbiota modulates host amino acid and glutathione metabolism in mice (2015)

The gut microbiota has been proposed as an environmental factor that promotes the progression of metabolic diseases. Here, we investigated how the gut microbiota modulates the global metabolic differences in duodenum, jejunum, ileum, colon, liver, and two white adipose tissue depots obtained from conventionally raised (CONV-R) and germ-free (GF) mice using gene expression data and tissue-specific genome-scale metabolic models (GEMs). We created a generic mouse metabolic reaction (MMR) GEM, reconstructed 28 tissue-specific GEMs based on proteomics data, and manually curated GEMs for small intestine, colon, liver, and adipose tissues. We used these functional models to determine the global metabolic differences between CONV-R and GF mice. Based on gene expression data, we found that the gut microbiota affects the host amino acid (AA) metabolism, which leads to modifications in glutathione metabolism. To validate our predictions, we measured the level of AAs and N-acetylated AAs in the hepatic portal vein of CONV-R and GF mice. Finally, we simulated the metabolic differences between the small intestine of the CONV-R and GF mice accounting for the content of the diet and relative gene expression differences. Our analyses revealed that the gut microbiota influences host amino acid and glutathione metabolism in mice.
Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH)in Vitro (1976)

Sixteen synthetic analogs of LH-releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 X 10(-9)M LHRH in anterior pituitary cells in monolayer culture. Half-maximal inhibition of LHRH-induced LH release was obtained with 7 analogs at concentrations which ranged from 3 X 10(-6)M to 3 X 10(-5)M. None of these seven analogs had significant LH-releasing activity at concentrations up to 10-5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000-fold molar ratio of analog to LHRH.
WVE-004, an investigational stereopure antisense oligonucleotide for the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (2302) (2021)

To determine the effects of WVE-004 on C9orf72 G4C2 repeat-containing transcripts, DPR proteins, and C9orf72 protein levels.
An ω-functionalized perfluoroalkyl chain: synthesis and use in liquid crystal design (1997)

S. Pensec and F. Tournilhac, Chem. Commun., 1997, 441 DOI: 10.1039/A700085E
Evaluation of copper thick film for high frequency digital interconnection (2003)

Copper thick-film multilayer technology is evaluated for use as a high-frequency digital interconnect in systems with bit rates up to 600 Mb/s. To help design the interconnect, software tools which calculate the electrical parameters and performance for any two-dimensional geometry were developed and are described. The analysis is based on a quasistatic method. A thick-film multilayer test structure with high bandwidth and 50- Omega impedance was realized. The calculated line parameters show good agreement with the measured values.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A new vertical‐alignment LC mode with high‐transmittance and fast‐response‐time features (2011)

Abstract— A novel pixel design for vertical‐alignment LCDs with superior transmittance has been developed. The new liquid‐crystal mode, refered to as the hole‐induced vertical‐alignment mode (Hi‐VA), uses a via hole of an organic layer on a TFT substrate to achieve multi‐domain alignment. Compared to the conventional design, the Hi‐VA mode has a transmittance of up to 135% with a contrast ratio of 2000:1. Moreover, the new structure is free from ITO patterning or protrusion on the color‐filter side, which makes the fabrication process simple and low cost.
Dual Targeting of EGFR and IGF1R in the TNFAIP8 Knockdown Non–Small Cell Lung Cancer Cells (2019)

Aberrant regulation of EGFR is common in non-small cell lung carcinomas (NSCLC), and tumor resistance to targeted therapies has been attributed to emergence of other co-occurring oncogenic events, parallel bypass receptor tyrosine kinase pathways including IGF1R, and TNFα-driven adaptive response via NF-κB. TNFAIP8, TNFα-inducible protein 8, is an NF-κB-activated prosurvival and oncogenic molecule. TNFAIP8 expression protects NF-κB-null cells from TNFα-induced cell death by inhibiting caspase-8 activity. Here, we demonstrate that knockdown of TNFAIP8 inhibited EGF and IGF-1-stimulated migration in NSCLC cells. TNFAIP8 knockdown cells showed decreased level of EGFR and increased expression of sorting nexin 1 (SNX1), a key regulator of the EGFR trafficking through the endosomal compartments, and treatment with SNX1 siRNA partially restored EGFR expression in these cells. TNFAIP8 knockdown cells also exhibited downregulation of IGF-1-induced pIGF1R and pAKT, and increased expression of IGF-1-binding protein 3 (IGFBP3), a negative regulator of the IGF-1/IGF1R signaling. Consistently, treatment of TNFAIP8 knockdown cells with IGFBP3 siRNA restored pIGF1R and pAKT levels. TNFAIP8 knockdown cells had enhanced sensitivities to inhibitors of EGFR, PI3K, and AKT. Furthermore, IHC expression of TNFAIP8 was associated with poor prognosis in NSCLC. These findings demonstrate TNFAIP8-mediated regulation of EGFR and IGF1R via SNX1 and IGFBP3, respectively. We posit that TNFAIP8 is a viable, multipronged target downstream of the TNFα/NF-κB axis, and silencing TNFAIP8 may overcome adaptive response in NSCLC. IMPLICATIONS: TNFAIP8 and its effectors SNX1 and IGFBP3 may be exploited to improve the efficacy of molecular-targeted therapies in NSCLC and other cancers.<b>Visual Overview:</b> http://mcr.aacrjournals.org/content/molcanres/17/5/1207/F1.large.jpg.
18F-FDG PET and CT Scans Detect New Imaging Patterns of Response and Progression in Patients with Hodgkin Lymphoma Treated by Anti–Programmed Death 1 Immune Checkpoint Inhibitor (2017)

The response evaluation criteria in patients with Hodgkin lymphoma (HL) were designed for the assessment of chemotherapy and targeted molecular agents. We investigated the accuracy of 3-mo <sup>18</sup>F-FDG PET/CT for the identification of HL patients responding to immune-checkpoint blockade by anti-programmed death 1 antibodies (anti-PD1). We also reported the frequency of new immune patterns of response and progression. <b>Methods:</b> Retrospectively, we recruited consecutive HL patients treated by anti-PD1 (pembrolizumab or nivolumab) at Gustave Roussy from 2013 to 2015. <sup>18</sup>F-FDG PET/CT and contrast-enhanced CT scans were acquired every 3 mo. We recorded the best overall response according to the International Harmonization Project Cheson 2014 criteria and LYmphoma Response to Immunomodulatory therapy Criteria (LYRIC) (2016 revised criteria). Patients achieving an objective response at any time during the anti-PD1 treatment were classified as responders. <b>Results:</b> Sixteen relapsed or refractory classic HL patients were included. The median age was 39 y (age range, 19-69 y). The median previous lines of therapy was 6 (range, 3-13). The mean follow-up was 22.6 mo. Nine of 16 patients (56%) achieved an objective response. Two deaths occurred due to progressive disease at 7 mo. <sup>18</sup>F-FDG PET/CT detected all responders at 3 mo and reclassified best overall response in 5 patients compared with CT alone. A decrease in tumor metabolism and volume (SUV<sub>mean</sub>, metabolic tumor volume) and increase in healthy splenic metabolism at 3 mo were observed in responders (area under the curve > 0.85, <i>P</i> < 0.04). Five of 16 patients (31%) displayed new imaging patterns related to anti-PD1; we observed 2 transient progressions consistent with indeterminate response according to the LYRIC (2016) (IR2b at 14 mo and IR3 at 18 mo) and 3 patients with new lesions associated with immune-related adverse events. <b>Conclusion:</b> Three-month <sup>18</sup>F-FDG PET/CT scans detected HL patients responding to anti-PD1. New patterns were encountered in 31% of patients, emphasizing the need for further evaluation in larger series and close collaboration between imaging and oncology specialists on a per-patient basis.
PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH COCAINE USE (2021)

This case demonstrates a potential unique etiology of paracentral acute middle maculopathy following exposure to cocaine. Paracentral acute middle maculopathy may occur in the setting of cocaine use. Optical coherence tomography evaluation with close surveillance can be helpful to identify the often subtle findings of paracentral acute middle maculopathy in cases of vision loss associated with illicit drug use.
Computational Simulation Model to Predict Behavior Changes in Inflammatory Bowel Disease Patients during the COVID-19 Pandemic: Analysis of Two Regional Japanese Populations (2023)

Managing inflammatory bowel disease (IBD) is a major challenge for physicians and patients during the COVID-19 pandemic. To understand the impact of the pandemic on patient behaviors and disruptions in medical care, we used a combination of population-based modeling, system dynamics simulation, and linear optimization. Synthetic IBD populations in Tokyo and Hokkaido were created by localizing an existing US-based synthetic IBD population using data from the Ministry of Health, Labor, and Welfare in Japan. A clinical pathway of IBD-specific disease progression was constructed and calibrated using longitudinal claims data from JMDC Inc for patients with IBD before and during the COVID-19 pandemic. Key points considered for disruptions in patient behavior (demand) and medical care (supply) were diagnosis of new patients, clinic visits for new patients seeking care and diagnosed patients receiving continuous care, number of procedures, and the interval between procedures or biologic prescriptions. COVID-19 had a large initial impact and subsequent smaller impacts on demand and supply despite higher infection rates. Our population model (Behavior Predictor) and patient treatment simulation model (Demand Simulator) represent the dynamics of clinical care demand among patients with IBD in Japan, both in recapitulating historical demand curves and simulating future demand during disruption scenarios, such as pandemic, earthquake, and economic crisis.
Addressing nanoantennas with slow Bloch mode cavity: application to optical trapping (2017)

International audience
Supplementary Figures from Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment (2023)

&lt;p&gt;Supplementary Figures - PDF file 322K, S1. Spontaneous MMTVneu display high Her2/neu expression. S2. FoxP3 expression among CD4+ CD25+ T cells correlates with CD45RB negativity. S3. NEU15WT TApDC display unaltered uptake ability. S4. NEU15WT TApDC display unaltered TLR7 and TLR9 expression. S5. Fold changes in gene expression upon intratumoral TLR7L injection. S6. Intratumoral TLR7L or CpG injection induced distinct immune cell recruitment. S7. List of flurochrome-conjugated antibodies used for multi-parametric flow cytometry analysis&lt;/p&gt;
Psychometric artificial intelligence (2011)

Rather long ago, Newell (1973) wrote a prophetic paper that can serve as a rallying cry for this special issue of JETAI: ‘You Can't Play 20 Questions with Nature and Win’. This paper helped catalys...
Morphology and Crystallization of NR in SBR/NR Blends (2003)

Isothermal crystallization behavior of natural rubber (NR) dispersed in styrene-butadiene rubber (SBR) was studied at -25°C in terms of dilatometry. NR was crosslinked with dicumyl peroxide to prepare lightly crosslinked model compounds to investigate the effect of naturally occurring-branching structure on the crystallization behavior. The morphological feature of NR dispersed in SBR matrix was significantly dependent upon cross-link density, reflecting the empirical relationship between morphology and viscosity associated with cross-link density. The rate of crystallization and value of Avrami index of NR dispersed in SBR matrix was a strong function of domain size.
MEMS triaxial gyroscope using surface and sidewall doping piezoresistors (2020)

Abstract This paper describes a MEMS triaxial gyroscope utilizing three-dimensional piezoresistive elements. MEMS gyroscopes are widely used for robot motion control, drones, mobile phones and so on. Although a piezoresistive sensing element has the potential for high sensitivity to angular velocity via vibrations that occur due to the Coriolis force, a commonly used piezoresistor, which is formed on a device surface, is not suitable to measure in-plane deformations. Thus, it is difficult to realize a sensing element for a triaxial gyroscope with conventional piezoresistors, especially an element for the detection of vertical axis angular velocity. Here, we propose a triaxial gyroscope utilizing surface and sidewall doping piezoresistors as the sensing element. The surface and sidewall doping piezoresistors detect out-of-plane and in-plane vibrations due to the corresponding three-dimensional Coriolis forces, respectively. As a result, the triaxial angular velocity becomes measurable. The experimental results show that the fabricated gyroscope responds to three-dimensional angular velocities with low crosstalk. Therefore, the proposed gyroscope is suitable for practical angular velocity measurement applications.
Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study (2018)

Radium-223 was tolerated when combined with weekly paclitaxel, with no clinically relevant additive toxicities. This combination should be explored further in patients with bone metastases.
Supplementary Figure 3 from The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog–Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog–Treated Cerebellar Neural Precursors (2023)

Supplementary Figure 3 from The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog–Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog–Treated Cerebellar Neural Precursors
Multiple-Micronutrient Fortification Technology Development and Evaluation: From Lab to Market (2003)

At the World Summit for Children (New York, 1990), a resolution was passed to eliminate vitamin A and iodine deficiencies and significantly reduce iron-deficiency anemia by the year 2000. In responding to this urgent call, we developed a unique multiple-micronutrient fortification delivery system called "GrowthPlus/CreciPlus." Using this technology, a fortified powder fruit drink has been formulated and extensively evaluated. One serving of the product delivers the following US recommended dietary allowances: 20-30% of iron; 10-35% of vitamin A; 25-35% of iodine; 100-120% of vitamin C; 25-35% of zinc; 15-35% of folate; and 10-50% of vitamins E, B2, B6, and B12. This was accomplished through (a) identifying and selecting the right fortificants, and (b) understanding their chemical and physical properties that contribute to multiple problems (product acceptability, stability, and bioavailability). Data from a home-use test showed fortification with the "Multiple-Fortification Technology" has no effect on the appearance and taste of the eventually consumed powder fruit drink. One-year stability studies demonstrated that iodine and the vitamins have adequate stability. Bioavailability evaluation by using double-isotope labeling technique showed that the iron from the fortified powder drink has excellent bioavailability (23.4% +/- 6.7). In conclusion, a powder fruit drink has been clinically demonstrated to deliver multiple micronutrients, which include adequate levels of bioavailable iron, vitamin A, iodine, zinc, vitamin C, and B vitamins, without compromising taste, appearance, and bioavailability. The critical limiting step in the micronutrient fortification program is the production and distribution of the multiple-micronutrient-fortified product. The fortified powder drink was marketed in Venezuela under the brand name NutriStar.
Design and Modeling of Metamorphic Dual-Junction InGaP/GaAs Solar Cells on Si Substrate for Concentrated Photovoltaic Application (2014)

We have investigated the concentrated photovoltaic performance of metamorphic monolithic InGaP/GaAs dual-junction (2-J) solar cells on Si substrate under AM1.5d spectrum using finite-element analysis. The current-matching condition between each subcell was realized for threading dislocation density varying from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , emanating from the mismatch between GaAs and Si substrate. Through comprehensive cell design and by mitigating the losses due to shadowing effect and series resistance, we present an optimal cell design for harnessing the maximum potential of 2-J InGaP/GaAs cell integrated on Si substrate for concentrated photovoltaics. The optimization of front grid spacing and sheet resistance of the window layer were the key design parameters taken into consideration for extending the peak performance toward higher concentrations. Finally, we present an optimized 2-J InGaP/GaAs cell design on Si, which exhibited a theoretical conversion efficiency of 33.11% at 600 suns at a realistic TDD of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , indicating a promising future for integrating III-V cell technology on Si for low-cost concentrated photovoltaics.
High‐Speed Packet Access Evolution (HSPA+) in 3GPP Release 7 (2007)

This chapter contains sections titled: Introduction Setup Time Reduction Peak Data Rate Increase with MIMO and 16QAM/64QAM Layer 2 Optimisation Throughput Evolution with Enhanced Terminals Mobile Power Consumption Reduction with Continuous Packet Connectivity Voice-over-IP (VoIP) Capacity Enhancements Flat Architecture Summary References
C to H effective ratio as a descriptor for co-processing light oxygenates and CH4on Mo/H-ZSM-5 (2014)

Co-processing of H2O, CO2, and light (C1–2) oxygenates with CH4 at 950 K over Mo/H-ZSM-5 catalysts results in complete fragmentation of the oxygenate and CO as the sole oxygen-containing product. The C/Heff accounts for removal of O as CO and describes the net C6H6 and total hydrocarbon synthesis rates at varying (0.0–0.10) oxygenate and H2 to CH4 co-feed ratios.
Performance comparison and node failure assessment of energy efficient two level balanced and progressive sensor networks (2012)

This research is concerned with the design of Tree WSNs. This research proves that configuration plays a vital role in energy optimisation, node failure and network lifetime when designing a Tree WSN. We compare a Progressive Two Level Tree WSN with a Balanced Two Level Tree WSN. Our simulation results prove that a Progressive configuration has two advantages, over a Balanced configuration, which are less computations required to complete each process and more tolerance of node failures. These Progressive configuration advantages both lead to more energy efficiency compared to a Balanced configuration. Therefore, the lifetime of a Progressive Two Level Tree WSN is longer than that of a Balanced Two Level Tree WSN.