gebhart/patrepeval huggingface dataset:
The relative atherogenicity of VLDL and LDL is dependent on the topographic site (2010)

To evaluate whether the relative atherogenicity of VLDL and LDL is dependent on the topographic site, atherosclerosis was compared at four topographic sites in homozygous LDL receptor (LDLr)-deficient rabbits fed normal chow and in heterozygous LDLr-deficient rabbits with the same genetic background fed a 0.15% cholesterol diet to match cholesterol levels. VLDL cholesterol was significantly higher and LDL cholesterol significantly lower in LDLr(+/-) diet rabbits compared with LDLr(-/-) rabbits. Intimal area in the ascending thoracic aorta and in the abdominal aorta at the level of the renal arteries was 1.4-fold (P < 0.05) and 1.5-fold (P < 0.05) higher, respectively, in LDLr(-/-) rabbits than in LDLr(+/-) diet rabbits, whereas no significant difference occurred in the descending thoracic aorta and in the abdominal aorta just above the bifurcation. Differences remained statistically significant after adjustment for plasma cholesterol, triglycerides, and sex. Compared with LDLr(+/-) diet rabbits, higher intimal lipoprotein lipase (LPL) and apolipoprotein (apo) B levels were observed in LDLr(-/-) rabbits only at the level of the descending thoracic aorta. Intimal apo E levels in LDLr(-/-) rabbits were significantly lower in sites with a larger intima than in LDLr(+/-) diet rabbits. In conclusion, the relative atherogenicity of VLDL and LDL is dependent on the topographic site.
[Complementary value of the isoprenaline test and high-amplification ECG in the diagnosis of arrhythmogenic dysplasia of the right ventricle]. (1992)

Arrhythmogenic dysplasia of the right ventricle is a common cause of ventricular arrhythmia. It is important to reach a diagnosis, due to the risk of sudden death, particularly as this may be the first sign of the disease. Diagnosis is based on the angiographic demonstration of a morphological or structural abnormality of the right ventricle, and non-invasive tests are relatively insensitive. From a case investigated in 1984, the authors carried out a prospective determination of the diagnostic value of the isoprenaline test in 61 patients suffering from arrhythmogenic dysplasia of the right dysplasia confirmed by angiography. High concentrations (8-30 micrograms/min) of isoprenaline were continuously infused over a period of 3 minutes, regardless of the heart rate achieved. In a control group of 50 subjects with no myocardial disorder, isoprenaline induced monomorphic wave-burst arrhythmia in only one patient (2%). In the subjects affected by right ventricular arrhythmogenic dysplasia, isoprenaline induced one or more episodes of wave-burst ventricular arrhythmia in 52 patients (85%): one triplet in four patients, several episodes of wave-burst arrhythmia in 31 patients and prolonged ventricular tachycardia in 17 patients. Polymorphic arrhythmia occurred in 80% of cases, but left lag forms predominated. High-amplification ECG demonstrated late potentials in 66% of cases, i.e. in 80 and 62% of patients with and without prolonged VT respectively. The isoprenaline test or high-amplification ECG gave abnormal results in 58 of the 61 patients, with a cumulative sensitivity of 95 percent.
ChemInform Abstract: Probing the Topography of Kainate Recognition Sites: Synthesis of a Novel Oxetane‐Containing Kainic Acid Analogue. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Broadband Packet Wire Appropriate for High-speed and Hig ess Access 1-capacity Throughput (2000)

This paper evaluates the optimum broadband packet wire- less access scheme using a 50-100 MHz bandwidth to achieve high- speed packet transmission taking into consideration the realization of high-speed and high-capacity packet transmission, the accommo- dation of variable rate services with different quality requirements, and the extendibility for and commonality to the IMT-2000. In the forward link, the presented simulation results associated with the evaluation of key features show that multi-carrier CDMA (MC- CDMA) is the most promising candidate, since it achieves the high- est-capacity packet transmission in a severe multipath fading chan- nel due to a lower symbol-rate with numerous sub-carriers and a channel coding gain accompanied by the frequency diversity effect. Meanwhile, single-carrierDS-CDMA and multi-carrierDS-CDMA (SCDS-CDMA and MCDS-CDMA) are severely degraded due to significantly increasing multipath interference, and orthogonal be- quency division multiplexing (OFDM) lacks efficient cell deploy- ment due to the necessity of frequency reuse in a multi-cell environ- ment without complicated dynamic channel assignment @CA). Fur- thermore, in the reverse link, we conclude that MC(SC)/DS-CDMA is a promising candidate because it has advantages such as an effec- tive random access method, soft handover, and an inherent property for accurate location detection.
ChemInform Abstract: Poststatin, a New Inhibitor of Prolyl Endopeptidase. Part 3. Optical Resolution of 3‐Amino‐2‐hydroxyvaleric Acid and Absolute Configuration of Poststatin. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Radionuclides for Therapy (2008)

Molecular radiotherapy (MRT) is a systemically administered targeted radionuclide therapy. The prototypical example of radionuclide therapy is radioidine treatment of thyroid cancer. Differentiated (papillary and follicular) thyroid carcinoma cells have the ability to concentrate iodine as part of the molecular machinery for making thyroid hormone. Medullary thyroid cancer treatment with radioiodine illustrates targeting of the radionuclide without the need for a carrier that recognizes tumor cells. The majority of targeted radionuclide therapy has been performed with radiolabeled antibodies. The Bexxar and Zevalin therapeutic regimens are based on intact antibodies. A lower molecular weight class of molecular radiotherapeutics, radiolabeled peptides has been the focus of European investigators. These peptides can achieve binding affinities in the low nanomolar range and have been found to be nonimmunogenic. Metaiodobenzylguanidine (MIBG) is an aralkylguanidine analog of catecholamine precursors, structurally similar to norepinephrine, which concentrates within secretory granules of catecholamine producing cells.
The influence of longitudinal tyre dynamics on ABS braking of a quarter vehicle model (1998)

For efficient analysis it is important to choose the proper model that fits the problem that needs to be solved. This paper discusses three pragmatic simulation models for longitudinal behaviour of a passenger car tyre (steady State, Transient and Rigid Ring) that may be used in e.g. an ABS simulation. The characteristics of the simulation models are evaluated using some simple simulations. Simulations with a quarter vehicle model that includes load transfer effects are carried out to determine the deviation in results between the mentioned tyre models for an ABS application. The results show that the Steady State model may only be used below 10 Hz and that the Transient model is valid up to about 30 Hz. The results from the ABS simulation with the Rigid ring model are most reliable and are clearly different from the Steady State and Transient model, which indicates that ABS simulations should be carried out with the Rigid Ring model.
Doping of Ge–SixGe1−x core-shell nanowires using low energy ion implantation (2008)

We investigate the doping of germanium (Ge)–silicon germanium (SixGe1−x) core-shell nanowires (NWs) by low energy (3 keV) boron (B) ion implantation. Ge–SixGe1−x core-shell NWs were implanted with B atoms at different doses from 1×1014 to 1×1015 cm−2, and subsequently annealed for dopant activation. Using four-point, gate-dependent resistance measurements, we determine the resistivity, doping levels, and contacts resistance of the B-doped Ge–SixGe1−x NWs. Our findings show that depending on the implantation dose, the doping level of B-doped NWs ranges from 1×1018 to 2×1020 cm−3.
Mechanical and Thermal Characteristics of Bio-Nanocomposites Consisting of Poly-L-lactic Acid and Self-Assembling Siloxane Nanoparticles with Three Phases (2012)

Biopolymer nanocomposites (bio-nanocomposite) consisting of poly-L-lactic acid (PLLA) and siloxane nanoparticles with three phases, a high-density siloxane phase (plural cores), an elastomeric silicone phase, and a caprolactone oligomer phase, were developed to increase the mechanical properties of PLLA. The nanoparticles, average size of 13 nm, were self-assembled by aggregation and condensation of an organosiloxane with three units: isocyanatepropyltrimethoxysilane (IPTS), polymethylpropyloxysiloxane (PMPS), and a caprolactone oligomer (CLO), which form each phase. The bio-nanocomposite was produced using PLLA and the nanoparticles. Bending and tensile testing showed that the use of these nanoparticles (5 wt% in PLLA) greatly increases the tenacity (breaking strain) of PLLA while maintaining its relatively high breaking (maximum) strength. The elongation of the nanocomposite was more than twice that of PLLA while the elasticity modulus and breaking (maximum) strength were comparable to those of PLLA. The nanoparticles also increased the impact strength of PLLA. The use of the nanoparticles almost did not show adverse affect on the thermal resistance of PLLA. The nanocomposite’s heat resistance indicated by the glass transition temperature and heat distortion temperature was fairly kept. The decomposition temperature of the nanocomposite somewhat increased.
Biological activities of IC201 ((3S,8E)-1,3-dihydroxy-8-decen-5-one), a low molecular weight immunomodulator produced by Streptomyces. (1989)

IC201 was found in cultured broth of Streptomyces cirratus as an antitumor antibiotic which was effective in retarding growth of the established solid tumor of Ehrlich carcinoma by treatment starting 8 days after tumor inoculation. It retarded growth of the established solid tumor of IMC carcinoma but had no cytotoxicity at 100 micrograms/ml. IC201 treatment kept NK cell activity of tumor-bearing mice at normal level and stimulated cytostatic activity of peritoneal macrophages. It stimulated phagocytosis of yeast and phorbol myristate acetate-elicited superoxide production by peritoneal macrophages. The addition of IC201 to P388D1 cell cultures enhanced release of interleukin 1 (IL-1) into cultured supernatant but it affected lipopolysaccharide-induced IL-1 production. Although the addition to macrophage-depleted cultures did not show any stimulatory effect, mixed lymphocyte culture reaction was augmented in cultures using spleen cells as stimulator cells taken from mice given IC201. Results indicate that IC201 primarily activates macrophages and the activation may cause modulation of immune responses.
CD40 Expression in Uterine Tissues: A Key Regulator of Cytokine Expression by Fibroblasts1 (2001)

CD40 is a cell surface receptor initially discovered on cells of the hemopoietic lineage. Its primary role on immune cells is to enhance their activation and hence their production of cytokines and immunomodulatory molecules. Recently, CD40 has also been detected on human fibroblasts. An emerging view of the fibroblast is that it is far more than a structural cell, being capable of intimate interaction with cells of the immune system. In fibroblasts from several tissues, the engagement of CD40 with its ligand (CD40L) resulted in the secretion of proinflammatory molecules such as interleukin-6 (IL-6) and IL-8. Currently, there are few data about the presence of the CD40-CD40L system in female reproductive tissues. This study investigates the expression of CD40 by human endometrium, myometrium, and cervix both in situ and in tissue explant-derived fibroblasts. CD40 was detected mainly in the perivascular region of endometrium, myometrium, and cervix. Light staining for CD40 was observed in stromal elements. Additionally, the basal epithelium of cervix expressed CD40. Fibroblastic cells derived from all three sources express low levels of CD40, and this is up-regulated with interferon-gamma treatment (500 U/mL; 72 h). When activated with interferon-gamma and CD40L, the fibroblasts secreted increased amounts of IL-6, IL-8, and MCP-1. These data suggest that the CD40-CD40L system may provide a link between the resident structural cells of these reproductive tissues and the infiltrating immune cells or activated platelets that may express CD40L. The possible interaction of CD40 with CD40L may be particularly important during events such as menstruation and cervical ripening, where up-regulation of the proinflammatory molecules IL-6 and IL-8 is viewed as critical for these processes. In addition, dysregulation of this system may be a contributory factor to problems such as menstrual dysfunction and preterm labor.
Editorial: Impotence--The Quick Work-Up (1996)

No AccessJournal of UrologyClinical Urology: Editorial1 Dec 1996Editorial: Impotence--The Quick Work-Up Jacob Rajfer Jacob RajferJacob Rajfer More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65402-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial: Impotence--The Quick Work-Up." The Journal of Urology, 156(6), p. 1951 Division of Urology, Harbor/UCLA Medical Center, Torrance, California.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByLEHMANN K, EICHLISBERGER R and GASSER T (2018) LACK OF DIAGNOSTIC TOOLS TO PROVE ERECTILE DYSFUNCTION: CONSEQUENCES FOR REIMBURSEMENT?Journal of Urology, VOL. 163, NO. 1, (91-94), Online publication date: 1-Jan-2000.HATZICHRISTOU D, HATZIMOURATIDIS K, IOANNIDES E, YANNAKOYORGOS K, DIMITRIADIS G and KALINDERIS A (2018) NOCTURNAL PENILE TUMESCENCE AND RIGIDITY MONITORING IN YOUNG POTENT VOLUNTEERS: REPRODUCIBILITY, EVALUATION CRITERIA AND THE EFFECT OF SEXUAL INTERCOURSEJournal of Urology, VOL. 159, NO. 6, (1921-1926), Online publication date: 1-Jun-1998. Volume 156Issue 6December 1996Page: 1951 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Jacob Rajfer More articles by this author Expand All Advertisement PDF DownloadLoading ...
High-speed interconnect and packaging design of the IBM System z9 processor cage (2007)

This paper describes the system packaging and technologies of the IBM System z9™ enterprise-class server. The central electronic complex of the system consists of four nodes, each housing a multichip module (MCM) with 16 chips consuming up to 1,200 W. The z9™ server doubles the multiprocessor performance of the System z990 by increasing the central processing unit (CPU) configuration and using an internally developed elastic interface to increase interconnect speed on all high-speed buses. In contrast to all previous zSeries® designs, which were running at half of the processor speed, the packaging interconnects on the multichip module run at the same speed as the processor (1.72 GHz). High frequencies and massively parallel connectivity lead to a raw packaging bandwidth of up to 1,764 GB/s between processors and cache within a single frame for a fully configured four-node z9 system.
Supplementary Figure 3 from Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4<sup>+</sup> and CD8<sup>+</sup> T Cells Responses in Stage III and IV Melanoma Patients (2023)

&lt;p&gt;PDF file, 96K, Detection of tumor-specific T cells in SKIL cultures does not require challenge with defined epitopes. Tetramer analysis of SKILs cultured from biopsies of DTH reactions to DCs pulsed with tumor peptides (upper plots) or DCs electroporated with mRNA encoding tumor proteins (lower plots) of patients II-E-09 (A), II-E-03 (B), and II-E-10 (C). This figure shows that sampling DTH biopsy cultures with tetramers yields similar results when the patient is challenged with intradermal injections with DC pulsed with defined epitopes or DC electroporated with mRNA encoding the full tumor antigen.&lt;/p&gt;
Regulation of endothelial glutathione by ICAM‐1: implications for inflammation (2004)

The role of glutathione (GSH) in inflammation is largely discussed from the context of providing reducing equivalents to detoxify reactive oxygen and nitrogen species. Inflammation is now recognized to be an underlying cause of many vascular diseases including atherosclerosis, a disease in which endothelial GSH concentrations are decreased. However, mechanisms that control GSH levels are poorly understood. Key players in the inflammatory process are endothelial adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1). This adhesion molecule is present constitutively and can be induced by a variety of inflammatory stimuli. In this study, using mouse aortic endothelial cells (MAEC) deficient in ICAM-1, we demonstrate a novel interplay between constitutive ICAM-1 and cellular GSH. Deficiency of ICAM-1 was associated with an approximately twofold increase in total GSH content. Inhibiting glutamate-cysteine ligase (GCL), the enzyme that catalyses the rate-limiting step in GSH biosynthesis, prevented the increase in GSH. In addition, the catalytic subunit of GCL was increased (approximately 1.6-fold) in ICAM-1 deficient relative to wild-type cells, suggesting that constitutive ICAM-1 represses GCL expression. Furthermore, the ratio of reduced (GSH) to oxidized (GSSG) glutathione was also increased suggesting a role for ICAM-1 in modulating cellular redox status. Interestingly, increasing cytosolic GSH in wild-type mouse endothelial cells decreased constitutive ICAM-1, suggesting the presence of an inverse and reciprocal pathway. To test the effects of inducible ICAM-1 on GSH, cells were stimulated with the proinflammatory cytokine TNF-alpha. TNF-alpha stimulated production of ICAM-1, which was however not associated with induction of GSH. In contrast, supplementation of endothelial cells with GSH before TNF-alpha addition, inhibited induction of ICAM-1. These data suggest a novel regulatory pathway between constitutive ICAM-1 and GSH synthesis in the endothelium and are discussed in the context of modulating the inflammatory response.
Peptide N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) activates capsaicin‐sensitive primary afferent nerves in guinea‐pig atria and urinary bladder (1991)

1. We have investigated the ability of the N-formyl-methionyl-leucyl-phenylalanine (FMLP) a synthetic analogue of a chemotactic peptide derived from a variety of bacteria, to activate capsaicin-sensitive primary afferents in the guinea-pig atria and urinary bladder. 2. In the isolated, electrically-driven left atria from reserpine-pretreated guinea-pigs (atropine in the bath), FMLP (3 nM-1 microM) produced a biphasic positive inotropic response. The late component of this response was selectively abolished by in vitro capsaicin pretreatment while both the early and late responses were abolished by indomethacin. 3. The inotropic response to FMLP in the guinea-pig atria was unaffected by ruthenium red. The late but not the early response was strongly inhibited or abolished by tetrodotoxin (TTX), omega-conotoxin (CTX) or by the C-terminal fragment (8-37) of human alpha-calcitonin gene-related peptide (hCGRP). hCGRP-(8-37) acts as competitive antagonist at CGRP receptors. 4. In the guinea-pig isolated bladder, FMLP (10 nM-10 microM) produced a concentration-dependent contraction which was unchanged by previous in vitro capsaicin, TTX or CTX pretreatment. The response to low concentrations of FMLP was suppressed by indomethacin, irrespective of the capsaicin pretreatment. 5. FMLP (10 microM) produced a significant increase in the outflow of CGRP-like immunoreactivity (CGRP-LI) from superfused guinea-pig atria or urinary bladder. CGRP-LI outflow induced by FMLP was blocked by indomethacin or in vitro capsaicin pretreatment. 6. These findings indicate that FMLP activates the 'efferent' function of capsaicin-sensitive primary afferents via prostanoid generation. This action could provide a neurogenic contribution to the overall inflammatory response produced by bacteria-derived peptides in inflamed tissues. In addition the present data indicate that endogenous prostanoids generated during exposure to FMLP produce peptide secretion from sensory nerves via a TTX- and CTX-sensitive but ruthenium red-resistant mechanism.
Fully resolved Zeeman pattern in the Stern-Gerlach deflection spectrum ofO2(3Σg−, K=1) (1988)

The Stern-Gerlach magnetic deflection spectrum of a molecular beam of $^{16}\mathrm{O}_{2}$ cooled by supersonic expansion to its lowest rotational level (K=1) reveals nine spatially separated peaks within a span of 2 cm. These peaks readily are assigned from a calculation of the Zeeman energies of the K=1 spin-rotation sublevels characterized by ${M}_{J}$, and the assumption of a uniform field gradient within the deflecting magnet gap. However, the variable widths of the observed peaks and the decreasing deflection of certain ${M}_{J}$ peaks with increasing field above 14 kG require the explicit consideration of field-gradient inhomogeneities. The theory for this is developed and the spectral profiles again computed with field-gradient inhomogeneity and rotational temperature (${T}_{\mathrm{rot}}$) as variables. Agreement of the theoretical shifts, bandwidths, and relative intensities with increasing field gradient when compared with the experimental spectra is very good, and ${T}_{\mathrm{rot}}$ is found to be 3.5 K. The deflection spectrum of a beam of $^{17}\mathrm{O}_{2}$ differs from that of $^{16}\mathrm{O}_{2}$, reflecting the population of the K=0 rotational level in the $^{17}\mathrm{O}_{2}$ isotopomer. The oxygen dimer and trimer appear to be paramagnetic, but this result is tentative.
A 5‐Mpixel overhead projection display utilizing a nematic‐cholesteric phase‐transition liquid crystal (1993)

Abstract— A multiplexed high‐luminance liquid‐crystal projection display with 5 Mpixels (2240 × 2240 dots) at a luminance level of 800 cd/m 2 using a conventional overhead projector has been developed. This display exhibits the bistability of a nematic‐cholesteric phase‐transition liquid crystal without the use of polarizers, and can display 5‐Mpixel data which matches the output of a high‐resolution printer, using a conventional overhead projector. A 4:1 contrast ratio and 2.2‐ms line‐addressing time was achieved.
Is there a most appropriate channel spacing in WDM networks when individually routing 67 GBaud carriers? (2020)

As elastic optical transponders faster than 60 GBaud emerge in meshed terrestrial WDM networks, we investigate whether 75 GHz spectral channel spacing outperforms 87.5 GHz spacing when routing individual optical carriers transparently through optical nodes.