gebhart/patrepeval huggingface dataset:
ChemInform Abstract: BIS‐β,β′‐CONJUGATE ADDITION (1980)

Abstract α‐Funktionelle 2‐Methyl‐2‐cycloalkenone (I) reagieren mit den Diorgano‐Cu‐Li‐Verbindungen (II) zunächst zu den Addukten (III), die nach Eliminierung zu den Methylenketonen (IV) und nach Reaktion mit weiterem (II) über (V) zu den βJY‐bis‐konjugierten Addukten (VI) führen.
Synthesis and characterization of tetrakis(2,5-diisocyano-2,5-dimethylhexane)dihydridodiiridium(2+) tetraphenylborate.cntdot.toluene (1990)

The ^3(dσ *pσ) excited state of Ir_2(TMB)_4^(2+) (TMB = 2,5-diisocyano-2,5-dimethylhexane) reacts with hydrogen atom donors to give Ir_2(TMB)_4H_2^(2+) (Ir_2H_2). This d^7-d^7 dihydride has been isolated as a tetraphenylborate salt: v(Ir-H) 1940 cm^(-1), v(Ir-Ir) 136 cm^(-1). [Ir_2(TMB)_4H_2] [B(C_6H_5) _4]_2·CH_3C_6H_5, Ir_2C_(95)H_(114)N_8B_2, crystallizes in the monoclipic system, space group P2_1/c (No. 14), with a = 10.54 (2) Å, b = 31.02 (4) Å, and c = 27.05 (4) Å, β = 91.57 (3)°, V = 8841 (3) Å^3, and Z = 4. The Ir-Ir separation is 2.920 (2) Å, approximately 0.3 Å shorter than Ir-Ir in the d^8 dimer (lr_2) but ~0.1 Å longer than in the diiodide, Ir_2(TMB)_4I_2^(2+). The reaction of Ir_2H_2 with styrene gives Ir_2 and ethylbenzene.&#13;\n
Inherited neuromuscular diseases. Translation from pathomechanisms to therapies. (2009)

Preface Contributors Chapter 1: Pathology and Diagnosis of Muscular Dystrophies C. Navarro, S. Teijeira and B. San Millan Chapter 2: Standards of Care for Duchenne Muscular Dystrophy: Brief Treat-NMD Recommendations T. Sejerson and K. Bushby Chapter 3: Genetics and Pathogenesis of Distal Muscular Dystrophies B. Udd Chapter 4: Phenotype Variations in Early Onset Pompe Disease: Diagnosis and Treatment Results With Myozyme (R) S.I. Pascual Pascual Chapter 5: Diseases of the Human Mitochondrial Oxidative Phosphorylation System J. Montoya, E. Lopez-Gallardo, M.D. Herrero-Martin, I. Martinez-Romero, A. Gomez-Duran, D. Pacheu, M. Carreras, M.J. Lopez-Perez and E. Ruiz-Pesini Chapter 6: Mitochondrial Diseases: A Cross-Talk Between Mitochondrial and Nuclear Genomes A. Spinazzola and M. Zeviani Chapter 7: Mitochondrial Disorders Due to Nuclear Oxphos Gene Defects C. Ugalde, M. Moran, A. Blazquez, J. Arenas and M.A. Martin Chapter 8: Coenzyme Q10 Deficiencies in Neuromuscular Diseases R. Artuch, L. Salviati, S. Jackson, M. Hirano and P. Navas Chapter 9: The Role of Mitochondrial Network Dynamics in the Pathogenesis of Charcot-Marie-Tooth Disease F. Palau, A. Estela, D. Pla-Martin and M. Sanchez-Piris Chapter 10 : Pathogenesis and Treatment of Mitochondrial Disorders S. DiMauro and M. Hirano Chapter 11: Biology of Peripheral Inherited Neuropathies: Schwann Cell Axonal Interactions M.E. Shy Chapter 12: Phenotype and Clinical Evolution of Charcot-Marie-Tooth Disease Type 1A Duplication J. Berciano, A. Garcia, E. Gallardo, C. Ramon and O. Combarros Chapter 12: Genotypes & SensoryPhenotypes in 2 New X-linked Neuropathies (CMTX3 and dSMAX) and Dominant CMT/HMN Overlap Syndromes G. Nicholson, M. Kennerson, M. Brewer, J. Garbern and M. Shy Chapter 13: Natural History and Treatment of Peripheral Inherited Neuropathies D. Pareyson and C. Marchesi Chapter 14: Spinal Muscular Atrophy During Human Development: Where Are the Early Pathogenic Findings? E. Tizzano Chapter 15: Spinal Muscular Atrophy J. Vitte, R. Attali, N. Warwar, I. Gurt and J. Melki Chapter 14: Friedreich Ataxia: an Update on Animal Models, Frataxin Function and Therapies P. Gonzalez-Cabo, J.V. Llorens, F. Palau, M.D. Molto Chapter 15: Genetics and Pathogenesis of Inherited Ataxias and Spastic Paraplegias C. Espinos and F. Palau Chapter 16: Experimental Therapies of Demyelinating Neuropathies G. Meyer zu Horste and M.W. Sereda Index
EXPERIMENTAL RESEARCH OF RCS AND RCSR OF A STRAIGHT RECTANGLE TO ROUND SCOOP INLET (1999)

The Radar Cross Section (RCS) of a straight rectangle to round scoop inlet has been investigated. It includes the influences of the attack angle and termination on the electromagnetic scattering characteristics. Then the measurements of the Radar Cross Section Reduction (RCSR) of the inlet are put forward. At the same time, the effects of length, position of absorbing wave material and absorbing wave grille on RCSR are further studied. As the results indicate, the measurements suggested here have put very distinct effect on decreasing RCS of the inlet. This paper affords a technological basis for efficiently improving the low observable inlets.
Solid state crystalline and liquid crystalline structure of semifluorinated 1-bromoalkane compounds (1999)

A series of semifluorinated 1-bromoalkane (SFBA) mesogens have been synthesized and characterized to better understand their solid state crystalline and liquid crystalline structures. In the solid state, the local conformation of the fluorocarbon segments becomes disordered once the fluorocarbon chain reaches a length above eight CF units. This is evident from the pronounced decrease of molar melting enthalpy. An increasing amount of helix and helix reverse conformations and increasingly disordered packing can also be observed with each addition of a fluorocarbon segment. X-ray diffraction peaks in the small angle region can be indexed by a tilted, two dimensional layered (herring bone) structure. The crystal structure is similar to a type of plastic crystal in which the amphiphilic character is clear, because the two segments of fluorocarbon and hydrocarbon are almost immiscible. Heating of F(CF2)12(CH2)10Br leads to a transition from plastic crystal to smectic B, as revealed by time-resolved XRD and FTIR analysis. At this solid-to-liquid transition temperature, conformational analysis confirmed an onset of the CH2 gauche conformation within the hexagonal lattice, most likely due to changes occurring in the hydrocarbon segment, and a sudden increase of helix defects along the fluorocarbon segment. The disordered helix rigid-rod structure of the fluorocarbon segment and its poor compatibility with the hydrocarbon segment play an important role in the crystalline solid and liquid crystalline structures.
Subwavelength focusing and imaging from the far field using time reversal in subwavelength scaled resonant media (2017)

We show how using time dependent and broadband wave fields, alongside media structured at the subwavelength scale supporting resonant eigenmodes, permits to beat the diffraction limit from the far field for imaging or focusing purposes.
Pregnancy Outcomes in Women Exposed to Ustekinumab in the Crohnʼs Disease Clinical Development Program (2017)

Introduction: Ustekinumab (UST) has been approved for moderate to severe Crohn's Disease (CD) in adult patients (pts). While no adverse developmental outcomes (pre-& postnatal) were observed in animal studies of UST, limited data exist, including previously reported outcomes in psoriasis (PsO) pts, concerning the effects of UST on human pregnancies1. To characterize pregnancy outcomes in women exposed to UST during pregnancy, data from the UST CD clinical development program are presented. Methods: Pregnancies reported with maternal use of UST (typical terminal half-life of approx 3 weeks) from 5 CD studies were evaluated: 2 Phase 2 (C0379T07:n=131; CERTIFI:n=526) & 3 Phase 3 (UNITI-1:n=769 & UNITI-2:n=640, from which 1,281 continued on maintenance in IM-UNITI). Results: 877 female pts received ≥1 IV or SC dose of UST, and 26 maternal pregnancies were reported (despite agreeing to adequate birth control). UST treatment was discontinued upon the report of pregnancy in all cases. Mean maternal age was 27.6 years (range 19-43) and mean duration of UST exposure prior to the reported pregnancy was 76±62.1 weeks. Pregnancy outcomes were reported for 24 of 26 pregnancies (Table 1), including 15 (62.5%) live births (LBs), 4 (16.7%) spontaneous abortions (SAs), and 5 (20.8%) elective abortions. All 4 SAs occurred in the 1st trimester. Mean maternal age was older for pts who had SAs (33.0±2.94 years) vs. LBs (27.6±3.75 years) and median UST treatment duration was longer for pts who had SAs (80 weeks) vs. LBs (56 weeks). Among the LBs, there were no congenital anomalies; 1 infant had a single episode of transient hypoglycaemia treated with oral supplement. No safety signals emerged with neonatal outcomes with gestational age of 38.2±1.3 weeks (n=12), mean 5 min-APGAR of 9.8±0.45 (n=5), and mean birth weight of 6.6±1.6 pounds (n=13).Table: Table. Demographic data for Maternal PregnanciesConclusion: While the rate of SA's was generally comparable to the rate previously reported in PsO data, the small number of pregnancies among women with CD with prenatal exposure to UST precludes definitive interpretation of the data. While in this case series, SAs were associated with older maternal age, and longer duration of UST exposure prior to the reported pregnancy was not associated with adverse outcomes, the limited available data from the UST CD program requires additional research to determine pregnancy and newborn safety.
Heat Shock 70‐kDa Protein 8 Isoform 1 Is Expressed on the Surface of Human Embryonic Stem Cells and Downregulated upon Differentiation (2005)

The cell-surface markers used routinely to define the undifferentiated state and pluripotency of human embryonic stem cells (hESCs) are those used in mouse embryonic stem cells (mESCs) because of a lack of markers directly originated from hESC itself. To identify more hESC-specific cell-surface markers, we generated a panel of monoclonal antibodies (MAbs) by immunizing the irradiated cell clumps of hESC line Miz-hES1, and selected 26 MAbs that were able to bind to Miz-hES1 cells but not to mESCs, mouse embryonic fibroblast cells, and STO cells. Most antibodies did not bind to human neural progenitor cells derived from the Miz-hES1 cells, either. Of these, MAb 20-202S (IgG1, kappa) immunoprecipitated a cell-surface protein of 72-kDa from the lysate of biotin-labeled Miz-hES1 cells, which was identified to be heat shock 70-kDa protein 8 isoform 1 (HSPA8) by quadrupole time-of-flight tandem mass spectrometry. Immunocytochemical analyses proved that the HSPA8 protein was also present on the surface of hESC lines Miz-hES4, Miz-hES6, and HSF6. Two-color flow cytometric analysis of Miz-hES1 and HSF6 showed the coexpression of the HSPA8 protein with other hESC markers such as stage-specific embryonic antigen 3 (SSEA3), SSEA4, TRA-1-60, and TRA-1-81. Flow cytometric and Western blot analyses using various cells showed that MAb 20-202S specifically bound to the HSPA8 protein on the surface of Miz-hES1, contrary to other anti-HSP70 antibodies examined. Furthermore, the surface expression of the HSPA8 protein on Miz-hES1 was markedly downregulated upon differentiation. These data indicate that a novel MAb 20-202S recognizes the HSPA8 protein on the surface of hESCs and suggest that the HSPA8 protein is a putative cell-surface marker for undifferentiated hESCs.
Fully confined photonic band gap and guided modes in a two-dimensional photonic crystal slab (1999)

A new two-dimensional photonic crystal (2D PC) slab structure was created with a full three-dimensional light confinement. Guided modes with broad bandwidth and high transmission within the band gap are also observed. As an optical analog to electronic crystals, PC promises a revolution in the photonic world similar to the electronic revolution created by the electronic band gap engineering in semiconductor. 2D PC has an advantage of being easier to fabricate at optical wavelength ({lambda}) comparing with 3D PC. However, the light leakage in the vertical direction has been the main problem for using 2D PC in opto-electronic application. In this study, the authors solve this problem by combining traditional 2D PC with strong vertical index guiding between the waveguide layer (GaAs) and the cladding layer (Al{sub x}O{sub y}). A set of triangular lattice holes 2D PC's were fabricated with lattice constant a=460nm, hole diameter (d=0.6a) and waveguide layer thickness (t = 0.5a). Those parameters were chosen to maximize the TE photonic band gap (PBG) around {lambda} = 1.55{micro}m. The depth of etched holes is {approximately}0.6{micro}m and the 2{micro}m thick Al{sub x}O{sub y} cladding layer is obtained by thermal oxidation of Al{sub 0.9}Ga{sub 0.1}As. PC waveguides were also created by introducing line defects along {Gamma}K direction. The authors perform transmission measurement by coupling light to PC with 3{micro}m wide waveguides which extends {approximately}0.6mm on both sides of PC. An aspheric lens with NA = 0.4 is used to focus the collimated light from tunable diode laser into the input waveguide. Another identical lens is used to collect the transmitted light and focus to an infrared (IR) camera and a calibrated photo-detector with a beamsplitter. The Gaussian waveguide mode indicates that the signal detected by the photodetector comes only from the light interacting with PC and propagating along the waveguide. The absolute transmittance is obtained by normalizing the transmission with a reference measured with a nominally identical waveguide without PC.
Orthoamide und Iminiumsalze, XC. Das RIBIL-Konzept – Reaktive Iminiumsalz-basierte ionische Flüssigkeiten (2015)

Zusammenfassung: Es wird vorgeschlagen, das Akronym „RIBIL“ für flüssige, reaktive, Iminiumsalz-basierte Verbindungen zu verwenden. Eine Zusammenstellung von strukturell unterschiedlichen RIBILs wird vorgestellt. Die Anwendung von RIBILs als Reaktionsmedium ist vorteilhaft, da sie bei geeigneter Wahl der Reaktanden eine besonders einfache Aufarbeitung erlaubt. Die Reaktion äquimolarer Mengen an aliphatischen Carbonsäuren und Alkoholen in N,N-Dimethyl-(hydroxymethylen)iminium-hydrogensulfat (DMF/H 2 SO 4 -Addukt) ( 20c ) führt zu Carbonsäureestern, die sich aus dem Reaktionsgemisch als zweite Phase abscheiden.
Femtosecond X-ray fluorescence from light elements excited by laser harmonics (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Hentschel, M. Schnürer, R. Kienberger, C. Spielmann, F. Krausz, C. Streli, and P. Wobrauschek, "Femtosecond X-ray fluorescence from light elements excited by laser harmonics," in Ultrafast Phenomena, T. Li, ed., Vol. 43 of OSA Trends in Optics and Photonics (Optica Publishing Group, 2000), paper MA6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
RX Equalization for a High-Speed Channel based on Bayesian Active Learning using Dropout (2020)

Determining optimal equalization settings in highspeed bus design simulations is becoming more important due to increased complexity and data rates of current server systems, but it is also time and resource consuming. In this paper, a probabilistic machine learning technique, Bayesian Active Learning using Dropout (BAL-DO), is utilized to perform RX equalization and optimization to address this issue. Largest HEYE opening and corresponding equalization settings are obtained with high prediction accuracy without performing extensive time-domain analysis, thereby significantly reducing the cost of engineering time and computational resources.
Managed Pressure Drilling in Marine Environments (2005)

Abstract Managed Pressure Drilling (MPD) is an advanced form of primary well control usually employing a closed and pressurizable drilling fluids system that allows more precise control of the wellbore pressure profiles than mud weight and mud pump rate adjustments alone. Unlike conventional open-to-atmosphere mud returns systems at the rig floor such as drilling or bell nipples, the circulating fluids system employed by MPD technology is more akin to that of a pressure vessel. Although the term, Managed Pressure Drilling or MPD is relatively new to the industry, having been first introduced in this context at the 2004 IADC/SPE Amsterdam Drilling Conference, the practice itself is not. In fact, the litany of techniques now defined by the IADC and to be included in the MPD chapter of SPE's new textbook, "Advanced Drilling Technology and Well Construction" have been evolving on land programs over the past two decades. This is particularly true in the United States where 3 out of 4 land drilling programs drill at least one section with a closed and pressurizable mud returns system, up from 1 in 10 in 1995. Of course, underbalanced drilling (UBD) requires such a system and a part of the uptake in usage is directly related to the growing practice of that technology which focuses upon enhancing the ultimate productivity of the well. However, most of the uptake is related to non-underbalanced applications and where the focus is not the reservoir, but upon dealing with drilling related issues; less drilling flat time, and enhanced control of the well. Unlike UBD that invites influx of hydrocarbons during the drilling process, MPD does not invite influx. The intent is to discourage influx by maintaining a state of effective overbalance whether drilling ahead or shut in to make jointed pipe connections. Any influx that may be incidental to MPD operations is contained with appropriate surface and downhole equipment and does so with fewer interruptions to the drilling program.
Duration of Symptoms and Association With Positive Home Rapid Antigen Test Results After Infection With SARS-CoV-2 (2022)

This cohort study assesses the duration of symptoms and association with positive rapid antigen test results after SARS-CoV-2 infection.
Self‐Organization in Pre‐5GCommunication Networks (2020)

The concepts of self-organizing networks (SONs) for mobile networks were introduced to cater for the increasing network management complexities. This chapter presents the state-of-the-art concepts on SON. It compares the traditional manual network management workflows with the SON-based network management and presents different architectural options for the implementation of SON solutions. The chapter discusses SON functions for the different phases of a mobile network lifecycle, such as planning, deployment, and operations. It describes various SON use cases, for example, mobility robustness optimization, to illustrate how SON functions help to minimize the network management complexities. The chapter discusses the supporting functions like SON coordination and minimization of drive tests (MDTs) to illustrate how SON integrates into the whole network management environments of mobile networks. It also highlights the challenges that are still open in the full automation of network management as well as the current design approaches for SON functions.
Detecting Cervical Cancer by Quantitative Promoter Hypermethylation Assay on Cervical Scrapings: A Feasibility Study (2004)

Current morphology-based cervical cancer screening is associated with significant false-positive and false-negative results. Tumor suppressor gene hypermethylation is frequently present in cervical cancer. It is unknown whether a cervical scraping reflects the methylation status of the underlying epithelium, and it is therefore unclear whether quantitative hypermethylation specific PCR (QMSP) on cervical scrapings could be used as a future screening method augmenting the current approach. Cervical scrapings and paired fresh frozen cervical tissue samples were obtained from 53 cervical cancer patients and 45 controls. All scrapings were morphologically scored and analyzed with QMSP for the genes APC, DAPK, MGMT, and GSTP1. To adjust for DNA input, hypermethylation ratios were calculated against DNA levels of a reference gene. Hypermethylation ratios of paired fresh frozen tissue samples and scrapings of cervical cancer patients and controls were strongly related (Spearman correlation coefficient, 0.80 for APC, 0.98 for DAPK, and 0.83 for MGMT; P < 0.001). More cervical cancer patients than controls were DAPK positive (P < 0.001). When cutoff levels for ratios were defined to be above the highest ratio observed in controls, QMSP in cervical scrapings identified 32 (67%) of 48 cervical cancer patients. This feasibility study demonstrates that QMSP on cervical scrapings holds promise as a new diagnostic tool for cervical cancer. The addition of more genes specifically methylated in cervical cancer will further improve the assay.
Investigation of Linewidth of Comb Modes in MZM-Based Flat Comb Generator with Optical Feedback Loop (2012)

We report on linewidth characteristics of comb signals generated by a Mach-Zehnder-modulator-based flat comb generator with an optical feedback loop. The linewidth of comb modes were narrower than that of the original laser.
Silicon Photonic ResonantHeater-Modulator. (2012)

Abstract not provided.
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221) (2013)

Abstract Macrophage migration inhibitory factor (MIF) and its receptor, CD74, are pivotal regulators of the immune system. Here we demonstrate for the first time that partial MHC class II constructs comprised of linked beta 1 alpha 1 domains with covalently attached antigenic peptides (also referred to as recombinant T cell receptor ligands - RTL) can inhibit MIF activity by not only blocking the binding of rhMIF to immunopurified CD74, but also down-regulating CD74 cell-surface expression. This bi-functional inhibition of MIF/CD74 interactions blocks downstream MIF effects, including enhanced secretion of proinflammatory cytokines, anti-apoptotic activity and inhibition of random migration that all contribute to reversal of clinical and histological signs of experimental autoimmune encephalomyelitis (EAE). Moreover, we demonstrate that enhanced CD74 cell surface expression on monocytes in mice with EAE and subjects with multiple sclerosis (MS) can be down-regulated by humanized RTL, resulting in reduced MIF binding to the cells. Thus, binding of partial MHC complexes to CD74 blocks both the accessibility and availability of CD74 for MIF binding and downstream inflammatory activity.
Preclinical Efficacy of Travoprost, a Potent and Selective FP Prostaglandin Receptor Agonist (2001)

Travoprost is the isopropyl ester prodrug of a high affinity, selective FP prostaglandin full receptor agonist. In contrast to travoprost acid's high affinity and efficacy at the FP receptor, there is only sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors. Travoprost produced a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 microg in the New Zealand albino (NZA) rabbit. Topical ocular application of travoprost produced a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 microg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 microg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 microg. Travoprost is a promising ocular hypotensive prostaglandin FP derivative that has the ocular hypotensive efficacy of PGF2alpha isopropyl ester but with less severe ocular side effects.