gebhart/patrepeval huggingface dataset:
Third emission mechanism in solid-state nanocavity quantum electrodynamics (2012)

Photonic crystal (PC) nanocavities have been receiving a great deal of attention recently because of their ability to strongly confine photons in a tiny space with a high quality factor. According to cavity quantum electrodynamics (cavity QED), such confined photons can achieve efficient interactions with excitons in semiconductors, leading to the Purcell effect in the weak coupling regime and vacuum Rabi splitting (VRS) in the strong coupling regime. These features are promising for applications such as quantum information processing, highly efficient single photon sources and ultra-low threshold lasers. In this context, the coupled system of a semiconductor quantum dot (QD) and a PC nanocavity has been intensively investigated in recent years.Although experimental reports have demonstrated such fundamental features, two anomalous phenomena have also been observed. First, photon emission from the cavity occurs even when it is significantly detuned from the QD. Second, spectral triplets are formed by additional bare-cavity lines between the VRS lines. These features cannot be explained by standard cavity QED theories and have prompted controversy regarding their physical mechanisms. In this review we describe the recent experimental and theoretical progress made in the investigation of these phenomena. Similar mechanisms will also occur in many other coupled quantum systems, and thus the findings are applicable to a wide range of fields.
Movement classification using ECoG high-gamma powers from human sensorimotor area during active movement (2017)

Neural activation in high-gamma range (>50 Hz) is robustly observed in sensorimotor area. Previous neurophysiological studies have indicated that there are dominant sensorimotor high-gamma power changes during active movement. Here, we demonstrate that two different movement types (hand grasping and elbow flection) can be discriminated at single-trial conditions with high accuracy using the spatial dynamics of high-gamma features from primary motor cortex. Based on our results, we propose that sensorimotor high-gamma activities during active movement can be a powerful feature for on-going movement classification, and their characteristics mainly represent the instant movement states.
Helicity in a Twist: Attosecond, Extreme Ultraviolet Vortex Beams with Designer Spin and Orbital Angular Momenta (2019)

High-harmonics—and attosecond pulses—with controllable spin and orbital angular momenta (SAM and OAM) are generated for the first time. The coupled SAM-OAM conservation laws enable exquisite control over the polarization of attosecond pulse trains.
Transistors: Ultrahigh Mobility in Solution‐Processed Solid‐State Electrolyte‐Gated Transistors (Adv. Mater. 16/2017) (2017)

A new concept of a high-capacitance flexible polymeric dielectric based on P(VDF-TrFE):P(VDF-HFP)-[EMIM] [TFSI] blends is reported by Yong-Young Noh and co-workers in article number 1605685. This solid-state electrolyte gate insulator enables remarkable field-effect mobilities exceeding 10 cm2 V−1 s−1 at Vg ≤ 2 V for common conjugated polymer, amorphous metal oxide, and carbon nanotube semiconductors. Such an impressive performance is achieved by a high areal capacitance of >4 μF cm−2 owing to the combined polarization of CF interface dipoles and electrical-double-layer formation.
Expression of recombinant human glucagon like peptide-1 by high density culture of E. coli (2002)

Objective: To express recombinant human glucagon like peptide-1 by high density fermentation culture of E. coli BL21(DE3). Methods: The recombinant plasmid pGEX-hGLP-1 was constructed successfully and was transformed into E. coli BL21(DE3). The optimization of induction condition was carried out in 500 ml shake flasks, followed by 5 L fermentor with high cell density culture to produce recombinant hGLP-1 in E. coli BL21(DE3)/pGEX-hGLP-1. Results: Batch and fed-batch culture by controlling carbon-nitrogen concentration and keeping oxygen at 30%-40% were used to obtain the final cell density (D_(600) = 52) and fusion protein GST-hGLP-1 (2.1 g/L). ESI-MS showed that the relative molecular mass of hGLP-1 was the same as expected. Conclusion: This study provides a basic work for production of recombinant hGLP-1 in scale.
Solution-Phase vs Surface-Phase Aptamer-Protein Affinity from a Label-Free Kinetic Biosensor (2013)

International audience
Sensitizer-modified proteins for solar-driven water splitting (2007)

Aerobic respiration and photosynthesis work in concert: Dioxygen liberated by photosynthetic organisms sustains life in aerobic&#13;\nmicrobes and animals; and, in turn, the products of aerobic respiratory metab., carbon dioxide and water, nourish&#13;\nphotosynthetic organisms. Electron flow through proteins and protein assemblies in the photosynthetic and respiratory&#13;\nmachinery commonly occurs between metal centers or other redox cofactors that are sepd. by relatively large mol. distances,&#13;\noften in the 10 to 20 angstrom range. Both theorists and experimentalists have worked long and hard in attempts to understand&#13;\nthe underlying physics and chem. of these electron transport processes. Lessons learned about the control of electron tunneling&#13;\nand hopping through org. and biol. mols. are now being used to design sensitizer-modified protein machines incorporating&#13;\ncatalysts that can generate hydrogen fuel from sunlight and water.
Genetic Alterations in Benign Adrenal Tumors (2022)

The genetic basis of most types of adrenal adenomas has been elucidated over the past decade, leading to the association of adrenal gland pathologies with specific molecular defects. Various genetic studies have established links between variants affecting the protein kinase A (PKA) signaling pathway and benign cortisol-producing adrenal lesions. Specifically, genetic alterations in <i>GNAS</i>, <i>PRKAR1A</i>, <i>PRKACA</i>, <i>PRKACB</i>, <i>PDE11A</i>, and <i>PDE8B</i> have been identified. The PKA signaling pathway was initially implicated in the pathogenesis of Cushing syndrome in studies aiming to understand the underlying genetic defects of the rare tumor predisposition syndromes, Carney complex, and McCune-Albright syndrome, both affected by the same pathway. In addition, germline variants in <i>ARMC5</i> have been identified as a cause of primary bilateral macronodular adrenal hyperplasia. On the other hand, primary aldosteronism can be subclassified into aldosterone-producing adenomas and bilateral idiopathic hyperaldosteronism. Various genes have been reported as causative for benign aldosterone-producing adrenal lesions, including <i>KCNJ5</i>, <i>CACNA1D</i>, <i>CACNA1H</i>, <i>CLCN2</i>, <i>ATP1A1,</i> and <i>ATP2B3</i>. The majority of them encode ion channels or pumps, and genetic alterations lead to ion transport impairment and cell membrane depolarization which further increase aldosterone synthase transcription and aldosterone overproduction though activation of voltage-gated calcium channels and intracellular calcium signaling. In this work, we provide an overview of the genetic causes of benign adrenal tumors.
Micromechanical photothermal spectroscopy of trace gases using functionalized polymers (2012)

We demonstrate a novel method to spectroscopically detect and identify trace gases. Micromechanical photothermal spectroscopy (MPS) with functionalized sorbent materials provides trace gas spectra in an optical interaction length of only a few micrometers. We use microcavity interferometry to read out displacements as low as 25 fm/√Hz, heating as low as 200 pW/√Hz, and analyte concentrations as low as 65 parts-per-billion for the nerve agent simulant DMMP. MPS integrated with functional materials represents an important new tool in chip-scale optical sensing.
<title>Developments towards practical free-space quantum cryptography</title> (2005)

We describe a free space Quantum cryptography system which is designed to allow continuous unattended key exchanges for periods of several days, and over ranges of a few kilometres. The system uses a four laser faint pulse transmission system running at a pulse rate of 10MHz to generate the required four alternative polarization states. The receiver module similarly automatically selects a measurement basis and performs polarization measurements with four avalanche photodiodes. The controlling software can implement the full key exchange including sifting, error correction, and privacy amplification required to generate a secure key.
Assemble Them All (2022)

Assembly planning is the core of automating product assembly, maintenance, and recycling for modern industrial manufacturing. Despite its importance and long history of research, planning for mechanical assemblies when given the final assembled state remains a challenging problem. This is due to the complexity of dealing with arbitrary 3D shapes and the highly constrained motion required for real-world assemblies. In this work, we propose a novel method to efficiently plan physically plausible assembly motion and sequences for real-world assemblies. Our method leverages the assembly-by-disassembly principle and physics-based simulation to efficiently explore a reduced search space. To evaluate the generality of our method, we define a large-scale dataset consisting of thousands of physically valid industrial assemblies with a variety of assembly motions required. Our experiments on this new benchmark demonstrate we achieve a state-of-the-art success rate and the highest computational efficiency compared to other baseline algorithms. Our method also generalizes to rotational assemblies (e.g., screws and puzzles) and solves 80-part assemblies within several minutes.
Adjusting Heart Rate During Sleep Using Activity Variance (1994)

This study supports using an estimate of activity variance to automatically decrease pacing rate below programmed base rate. This decrease may be actuated during an afternoon nap or nighttime sleep.
Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics (2013)

Understanding tear film dynamics is a prerequisite for advancing the management of Dry Eye Disease (DED). In this paper, we discuss the use of optical coherence tomography (OCT) and statistical decision theory to analyze the tear film dynamics of a digital phantom. We implement a maximum-likelihood (ML) estimator to interpret OCT data based on mathematical models of Fourier-Domain OCT and the tear film. With the methodology of task-based assessment, we quantify the tradeoffs among key imaging system parameters. We find, on the assumption that the broadband light source is characterized by circular Gaussian statistics, ML estimates of 40 nm +/- 4 nm for an axial resolution of 1 μm and an integration time of 5 μs. Finally, the estimator is validated with a digital phantom of tear film dynamics, which reveals estimates of nanometer precision.
Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses (2012)

A coordinated innate and adaptive immune response, orchestrated by antigen presenting cells (APCs), is required for effective clearance of influenza A virus (IAV). Although IAV primarily infects epithelial cells of the upper respiratory tract, APCs are also susceptible. To determine if virus transcription in these cells is required to generate protective innate and adaptive immune responses, we engineered IAV to be selectively attenuated in cells of hematopoietic origin. Incorporation of hematopoietic-specific miR-142 target sites into the nucleoprotein of IAV effectively silenced virus transcription in APCs, but had no significant impact in lung epithelial cells. Here we demonstrate that inhibiting IAV replication in APCs in vivo did not alter clearance, or the generation of IAV-specific CD8 T cells, suggesting that cross-presentation is sufficient for cytotoxic T lymphocyte activation. In contrast, loss of in vivo virus infection, selectively in APCs, resulted in a significant reduction of retinoic acid-inducible gene I-dependent type I IFN (IFN-I). These data implicate the formation of virus replication intermediates in APCs as the predominant trigger of IFN-I in vivo. Taking these data together, this research describes a unique platform to study the host response to IAV and provides insights into the mechanism of antigen presentation and the induction of IFN-I.
Intranidal aneurysms in cerebral arteriovenous malformations: evaluation and endovascular treatment. (1992)

Patients with cerebral arteriovenous malformations (AVMs) have an increased risk of hemorrhage if an intranidal aneurysm is present. Angiograms from 125 patients with cerebral AVMs were evaluated, and 15 (12%) had intranidal aneurysms. All 15 patients had a history of bleeding. Five patients underwent particulate or liquid embolization before surgical excision of or radiation therapy for the AVM. All aneurysms were thrombosed at the time of embolization. Ten patients underwent radio-surgery alone. Eight of the 10 underwent angiographic follow-up (mean, 33 months); seven patients showed complete obliteration of the AVM without residual aneurysm. Histologic evaluation showed intranidal aneurysms to be thin-walled vascular structures, and they are the likely site for AVM hemorrhage. Embolization is an effective method for achieving thrombosis of the intranidal aneurysm and may be beneficial in patients undergoing radiation therapy because of a long latency period between treatment and thrombosis of the AVM.
Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements (2016)

Several classes of signaling proteins contain autoinhibitory domains that prevent unwarranted signaling and coordinate the induction of activity in response to external cues. CARD11, a scaffold protein critical for antigen receptor signaling to NF-κB, undergoes autoregulation by a poorly understood inhibitory domain (ID), which keeps CARD11 inactive in the absence of receptor triggering through inhibitory intramolecular interactions. This autoinhibitory strategy makes CARD11 highly susceptible to gain-of-function mutations that are frequently observed in diffuse large B cell lymphoma (DLBCL) and that disrupt ID-mediated autoinhibition, leading to constitutive NF-κB activity, which can promote lymphoma proliferation. Although DLBCL-associated CARD11 mutations in the caspase recruitment domain (CARD), LATCH domain, and coiled coil have been shown to disrupt intramolecular ID binding, surprisingly, no gain-of-function mutations in the ID itself have been reported and validated. In this study, we solve this paradox and report that the CARD11 ID contains an unusual array of four repressive elements that function cooperatively with redundancy to prevent spontaneous NF-κB activation. Our quantitative analysis suggests that potent oncogenic CARD11 mutations must perturb autoinhibition by at least three repressive elements. Our results explain the lack of ID mutations in DLBCL and reveal an unusual autoinhibitory domain structure and strategy for preventing unwarranted scaffold signaling to NF-κB.
SOFTWARE/HARDWARE CO-DESIGN OF MODULAR EXPONENTIATION FOR EFFICIENT RSA CRYPTOSYSTEM (2013)

This paper presents an implementation of Rivest, Shamir and Adleman (RSA) cryptosystem based on hardware/software (HW/SW) co-design. The main operation of RSA is the modular exponentiation (ME) which is performed by repeated modular multiplications (MMs). In this work, the right-to-left (R2L) algorithm is used for the implementation of the ME as a programmable system on chip (PSoC). The processor MicroBlaze of Xilinx is used for flexibility. The R2L method is often suggested to improve the timing performance, since it is based on parallel computations of MMs. However, if the optimization of HW resources is a constraint, this method can be executed sequentially using a single modular multiplier as a custom intellectual property (IP). Consequently, the execution time of the ME becomes dependent of three factors, namely the capability of the custom IP to perform the MMs, the nonzero bit string of the exponent and the communication link between the processor and the custom IP. In order to achieve the best trade-off between area, speed and flexibility, we propose three implementations in this work. The first one is a pure software solution. The second one takes benefit of a HW accelerator dedicated to the MM execution. The last one is based on a dual strategy. Two parallel MMs are implemented within a custom IP and local memories are used close to the arithmetic units to minimize the communication link influence. The results show that in the application to RSA 1024-bits, the ME runs in 22,25 ms, while using only 1,848 slices.
Sociologie politique de l’action publique (2022)

Cette contribution montre combien l’article de Pierre Muller, « Les approches cognitives des politiques publiques » ( Revue française de science politique , 50 [2], avril 2000, p. 189-208), s’est avéré un papier de combat visant à établir l’analyse des politiques publiques comme un sous-champ essentiel de la science politique. Notre article reprend les questions majeures de l’ordre social et politique, d’une part, de l’autonomie des politiques publiques, d’autre part, qui sous-tendent la problématique de recherche articulée autour de la notion de référentiel. Il revient sur certaines dimensions de l’analyse, la différenciation avec d’autres théories concurrentes et élabore un bilan du référentiel qui, à la différence des questions posées par P. Muller, a perdu sa position centrale dans la sociologie politique de l’action publique. Il montre comment les enchevêtrements d’échelles et la multiplication des acteurs et des politiques ont rendu moins pertinentes la recherche d’un référentiel macro dans un cadre national, renforçant les approches en termes de discours, d’argumentation, d’idée plus situées et limitées. Mais avec la crise climatique, la question du « global » n’a pas dit son dernier mot.
Design of Simultaneously Stabilizing Controllers and Its Application to Fault-Tolerant Lane-Keeping Controller Design for Automated Vehicles (2004)

Simultaneous stabilization deals with the following question: given a finite number of LTI plants P/sub 1/,P/sub 2/,...P/sub k/ does there exist a single LTI controller C such that each of the feedback interconnections (P/sub i/,C) (i=1,2,...,k) is internally stable? This paper presents a new methodology for the design of simultaneously stabilizing controllers for two or more plants that satisfy a sufficient condition. A classic result from simultaneous-stability theory is invoked to cast the sufficient condition as a linear matrix inequality (LMI). It is shown that in this setting, the problem of design of simultaneously stabilizing controllers can be reduced to that of a standard H/sub /spl infin// control problem. The technique developed is applied to the design of a fault-tolerant controller for lane-keeping control of automated vehicles. The controller makes the system insensitive to a failure in either one of two lateral error measuring sensors used for lane-keeping control. Experimental results confirm the efficacy of the design and reinforce analytical predictions of performance.
Experimental evidence for strong UV transition contribution in the resonant nonlinearity of doped fibers (1997)

We report a new theoretical interpretation of the strong resonantly-enhanced third-order nonlinearity observed in fibers doped with Nd/sup 3+/, Er/sup 3+/, or Yb/sup 3+/. For each fiber, the absolute contributions of the near resonance (IR-visible) and far from resonance (UV) transitions to the nonlinearity are calculated and compared to experimental values. We show that in all cases, a large fraction of the measured nonlinearity is due to strong UV transitions. The consequences of this observation on the bandwidth, switching power and response time of switches based on this effect are discussed.
Electrical conduction in Si-implanted amorphous Si (1975)

The electrical properties of amorphous Si layers produced by Si implantation are similar to those of amorphous Si films obtained by evaporation or sputtering.Received 16 December 1974DOI:https://doi.org/10.1103/PhysRevB.11.4043©1975 American Physical Society
ChemInform Abstract: A Mild Procedure for the Lewis Acid‐Catalyzed Ring‐Opening of Activated Cyclopropanes with Amine Nucleophiles. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multi-mode filter bank solution for broadband PMR coexistence with TETRA (2014)

Fast convolution processing has recently been proposed as an efficient means for implementing filter bank multi-carrier systems with good spectral containment and high flexibility in tuning the subchannel bandwidths and center frequencies. These features make fast convolution filter banks (FC-FBs) a particularly interesting choice for multi-carrier transmission in challenging radio scenarios like dynamic spectrum access, cognitive radio, and fragmented spectrum use. In this contribution, the target is to study the performance of the FC-FB approach in heterogeneous radio environment. The focus is on the use of FC-FB for simultaneous processing of FB multi-carrier waveforms and narrowband TETRA signals.
Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias (1998)

The Philadelphia (Ph1) chromosome can be detected in chronic myelogenous leukemia (CML) and a significant number of acute lymphoblastic leukemia (ALL) cases. Generation of p210bcr/abl, a chimeric protein with enhanced kinase activity, is thought to be involved in the pathogenesis of these diseases. To elucidate the biological properties of p210bcr/abl and to create an animal model for human Ph1-positive leukemias, we generated transgenic mice expressing p210bcr/abl driven by the promoter of the tec gene, a cytoplasmic tyrosine-kinase preferentially expressed in the hematopoietic lineage. The founder mice showed excessive proliferation of lymphoblasts shortly after birth and were diagnosed as suffering from ALL based on surface marker and Southern blot analyses. Expression and enhanced kinase activity of the p210bcr/abl transgene product were detected in the leukemic tissues. In contrast, transgenic progeny exhibited marked granulocyte hyperplasia with thrombocytosis after a long latent period and developed myeloproliferative disorders (MPDs) closely resembling human CML. Expression of p210bcr/abl mRNA in the proliferating granulocytes was detected by RT-PCR. In particular, one MPD mouse showed remarkable proliferation of blast cells in the lung, which might represent an extramedullar blast crisis. The results demonstrate that the expression of p210bcr/abl in hematopoietic progenitor cells in transgenic mice can contribute to two clinically distinct hematopoietic malignancies, CML and ALL, indicating that this transgenic system provides a novel transgenic model for human Ph1-positive leukemias.