gebhart/patrepeval huggingface dataset:
Immunologic Control of the Ascites Form of Murine Adenocarcinoma 755. I. Protection With Syngeneic Immune Serum or Lymphoid Cells 2 (1978)

The ascites form of the mouse mammary adenocarcinoma 755 (AD755a) that originally arose in a C57BL mouse was used as a model system for the study of the induction of specific tumor immunity. Syngeneic C57BL/6J mice could be immunized against ip challenge with greater than 104 times the dose of AD755a cells necessary to kill 100% of mice by sc inoculation of the cells. The mice were resistant to further challenges for at least 3 months after immunization. Mice hyperimmunized by repeated sc and ip injections of AD755a cells served as donors of immune serum and lymphoid cells, each of which could transfer specific tumor immunity to nonimmunized mice. Protection with immune serum could be transferred with minute quantities of serum (as little as 5 μl) and appeared to have mouse strain specificity. Furthermore, protection against two other mouse tumors, both of which also arose as mammary carcinomas (Ehrlich ascites carcinoma and sarcoma 180), could be achieved by this procedure. Although transfer of protection could be obtained with immune splenocytes and mesenteric lymph node lymphocytes, it could not be obtained with thymocytes. Preliminary results suggested that the protective factor in immune serum was contained in the IgG fraction and had an effective half-life in vivo of greater than or equal to 4.5 days. Initial in vitro and in vivo experiments also indicated that the immune serum led to rosette formation between normal mouse lymphoid cells and the AD755a tumor cells, and these observations were discussed in terms of the possible mechanism(s) of serum-transferred protection.
Gamma‐ray polymerization of phospholipids having diene or triene groups as liposomes (1986)

Abstract Small unilamellar liposomes were prepared in an aqueous medium by the sonication of phospholipids containing diene or triene groups in their hydrocarbon acyl chains. These liposomes were polymerized by gamma‐ray irradiation. Conversion of polymerization was successively followed by UV spectrometry. Diene‐type lipid liposomes were revealed for which a gamma‐ray dose of 0.8 Mrad was required for complete polymerization and which were polymerized more easily than triene‐type lipid liposomes. Triene‐type lipids required 2.3 Mrad gamma ray to polymerize them completely. Contrary to UV‐irradiation polymerization, there was no concentration dependence on the polymerization. Structure of the polymerized liposomes were confirmed by electron microscopy as small unilamellar liposomes. Study on the leakage of fluorescein from inner aqueous phase of the polymerized liposomes revealed that polymerized triene‐type liposomes were relatively more stable than the polymerized diene‐type liposomes.
Wavelength Optimization in Femtosecond Laser Corneal Surgery (2013)

A wavelength change from the standard 1030 nm to 1650 nm in corneal surgery assisted by ultrashort pulse laser considerably reduces light scattering within the tissue. This results in a better preservation of the laser beam quality in the volume of the tissue, particularly when working at depths required for deep lamellar or penetrating keratoplasty. Using this wavelength yields improved penetration depths into the tissue; it permits use of lower energies for any given depth and thus reduces unwanted side effects as thermal effects.
Evaluation of Higher Efficiency Pr3+ Host Glasses for 1300 nm Amplification. (1993)

High gain amplification has been demonstrated at 1310 nm with a Pr-doped fluorozirconate fiber [1], but with a much lower pump efficiency than a comparable Er-doped silica amplifier at 1550 nm. This low pump efficiency is attributable to the low quantum efficiency of the lG4-&gt;3H5 transition of Pr3+ [2], which follows from the preponderance of multiphonon mediated decay from the 1G4 to the nearby 3F4 level. The probability of multiphonon decay between two energy levels is inversely related to the number of phonons required to bridge the energy gap. Therefore, the lowering of this probability and an improvement in the quantum efficiency would be expected through the use of a host material with lower phonon energies. In addition, an improvement in the quantum efficiency also would be expected in those materials with larger lG4-&gt;3H5 radiative rates. Over the last year a number of potentially more efficient host glasses have been reported [3,4,5,7]. Here we consider two of these, the mixed-halides [4] and the lanthanum gallium sulfide (LaGaS) [3], in detail.
An Active Metamaterial Platform for Chiral Responsive Optoelectronics (2015)

Chiral-selective non-linear optics and optoelectronic signal generation are demonstrated in an electrically active photonic metamaterial. The metamaterial reveals significant chiroptical responses in both harmonic generation and the photon drag effect, correlated to the resonance behavior in the linear regime. The multifunctional chiral metamaterial with dual electrical and optical functionality enables transduction of chiroptical responses to electrical signals for integrated photonics.
Observation of the Decay Ξb−→pK−K− (2017)

Decays of the Ξ_{b}^{-} and Ω_{b}^{-} baryons to the charmless final states ph^{-}h^{'-}, where h^{(')} denotes a kaon or pion, are searched for with the LHCb detector. The analysis is based on a sample of proton-proton collision data collected at center-of-mass energies sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3 fb^{-1}. The decay Ξ_{b}^{-}→pK^{-}K^{-} is observed with a significance of 8.7 standard deviations, and evidence at the level of 3.4 standard deviations is found for the Ξ_{b}^{-}→pK^{-}π^{-} decay. Results are reported, relative to the B^{-}→K^{+}K^{-}K^{-} normalization channel, for the products of branching fractions and b-hadron production fractions. The branching fractions of Ξ_{b}^{-}→pK^{-}π^{-} and Ξ_{b}^{-}→pπ^{-}π^{-} relative to Ξ_{b}^{-}→pK^{-}K^{-} decays are also measured.
Addition of Grignard Reagents to Aryl Acid Chlorides:  An Efficient Synthesis of Aryl Ketones (2005)

[chemical reaction: see text]. Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.
Federated Evaluation of On-device Personalization (2019)

Federated learning is a distributed, on-device computation framework that enables training global models without exporting sensitive user data to servers. In this work, we describe methods to extend the federation framework to evaluate strategies for personalization of global models. We present tools to analyze the effects of personalization and evaluate conditions under which personalization yields desirable models. We report on our experiments personalizing a language model for a virtual keyboard for smartphones with a population of tens of millions of users. We show that a significant fraction of users benefit from personalization.
Alkyl substituted 3‐PPP derivatives. Synthesis and biological investigation (1989)

Abstract Synthesis of alkyl substituted derivatives of 3‐(1‐propyl)3‐piperidinyl)phenol ( 3‐PPP ), 2–8 , was carried out in an attempt to improve on the pharmacodynamic properties of 3‐PPP. No significant improvement was attained.
Do seizures compromise correction maintenance after spinal fusion in cerebral palsy scoliosis? (2019)

Seizure disorder in cerebral palsy (CP) has been described as a risk factor for postoperative complications after posterior spinal fusion. However, the effect of seizures on the maintenance of curve correction has not been reported. The aim of this study is to investigate associations between seizure history and maintenance of curve correction after posterior spinal fusion in children with CP. We analyzed records of 201 children with CP who underwent posterior spinal fusion with two-year follow-up. Patients were classified as having no seizures (31%); controlled seizures (54%); or poorly controlled seizures (PCS, 15%). Perioperative data, radiographic measurements, and complications were compared between groups. Groups were similar in operative time, estimated blood loss, and rates of deep wound infection and implant-related complications. The PCS group had a higher rate of respiratory complications (27%) than the no seizures (10%; P = 0.03) and controlled seizures (12%; P = 0.04) groups. Controlled seizures and PCS groups had longer ICU stays than the no seizures group (P= 0.02 and P= 0.04). Major coronal curve and pelvic obliquity were corrected significantly in all groups, and correction was maintained at 2 years. Loss of correction during follow-up was similar between groups. Although seizures were associated with longer ICU stays and more respiratory complications, there was no association between seizure history and loss of curve correction at two years of follow-up after CP scoliosis surgery.
Supplementary Figure 2 from Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho (2023)

&lt;p&gt;Supplementary Figure 2&lt;/p&gt;
Jump-Diffusion Risk-Sensitive Asset Management II: Jump-Diffusion Factor\n Model (2011)

In this article we extend earlier work on the jump-diffusion risk-sensitive\nasset management problem [SIAM J. Fin. Math. (2011) 22-54] by allowing jumps in\nboth the factor process and the asset prices, as well as stochastic volatility\nand investment constraints. In this case, the HJB equation is a partial\nintegro-differential equation (PIDE). By combining viscosity solutions with a\nchange of notation, a policy improvement argument and classical results on\nparabolic PDEs we prove that the HJB PIDE admits a unique smooth solution. A\nverification theorem concludes the resolution of this problem.\n
Abstract 19318: Mitochondrial DNA Copy Number as a Predictor of Cardiovascular Disease (2014)

Mitochondrial dysfunction is a core component of cardiovascular disease (CVD) and is associated with several CVD risk factors (diabetes, cigarette smoke exposure, and hypertension). We therefore explored the association of mitochondrial DNA copy number, which reflects oxidative stress, with prevalent and incident CVD, and its potential utility as a novel clinical biomarker of CVD. We determined mtDNA copy number in DNA extracted from whole blood in 16,401 samples from two large multi-center prospective studies_the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) study. Lower mtDNA copy number was associated with increased prevalence of CVD in 4,109 white participants from CHS (OR for lowest quintile [Q1] to highest quintile [Q5] of mtDNA copy number=2.35, 95% CI=1.74-3.19, P 7.5%) risk. While we do not see the association with incident CVD in samples from CHS, this finding may reflect underlying differences in participants’ ages between the cohorts. The mean age in CHS is 72.4 years versus 58.1 years in ARIC suggesting that the association of mtDNA copy number with incident CVD may weaken with age. Given the magnitude of the effect we observe in ARIC, and the ease and low cost of the assay, we suggest that assessment of mtDNA copy number may have clinical utility for CVD risk classification warranting further validation in additional large prospective cohorts.
Ultrafiltration Rate Levels in Hemodialysis Patients Associated with Weight-Specific Mortality Risks (2023)

Ultrafiltration rates associated with various levels of higher mortality risk depend on body weight, but not in a 1:1 ratio, and are different in men versus women, in high-body weight older patients, and in high-vintage patients.
Infrequent Occurrence of Natural Mutations in the pp65495–503Epitope Sequence Presented by the HLA A∗0201 Allele among Human Cytomegalovirus Isolates (2001)

To determine if mutations of an immunodominant HLA-restricted cytomegalovirus (CMV) peptide sequence occur in nature, the sequence corresponding to the HLA A*0201-specific peptide CMVpp65(495-503) was determined in 50 human CMV isolates. Rare mutations were detected; 6 of 50 were silent mutations at the amino terminus of the peptide, while 3 of 50 were mutations of the native methionine residue to isoleucine (M499I). The observed M499I mutation in three isolates decreased cytolytic targeting.
Definition of a national program in energy-efficient pump utilization. First bi-monthly progress report, May 10, 1976-July 10, 1976 (1976)

Technical progress is reported in a study to assess the possibilities for significant energy savings in the pumping of fluids in the US. The goal of the study is to define improvements in pump design and operation which can be adopted by pump manufacturers and users to achieve energy savings. An industrial-economic survey of pump energy consumption is 60% complete. Pumps for automobile coolants, sewage plants, pipelines, power plants, buildings, industrial processes, etc., are included in this study. (LCL)
Adult Serum Cytokine Concentrations and the Persistence of Asthma (2013)

Our findings suggest a possible role for deficient IL-10 responses in the persistence of early-onset asthma. Lower IL-6 and TNF-α concentrations in serum from those with remitted asthma suggest that these proinflammatory cytokines may be actively suppressed during asthma remission.
Iron(III)-Catalyzed Nucleophilic Substitution of the Hydroxy Group in Benzoin by Alcohols (2012)

The etherification reaction between benzoin derivatives and alcohols catalyzed by iron(III) proceeds in moderate to good yields. Other metal complexes showed either low reactivity or low chemoselectivity where oxidation of benzoin to benzil was a competing reaction. The iron source operated as a catalyst where 5 mol% of iron(III) generate the 2-alkoxy-1,2-diphenylethan-1-one in 50% yield. With an optimum of 25 mol% of catalyst, the desired ether was obtained in 85% yield. The etherification of benzoin and an alcohol proceed to generate the desired product in polar solvents such as 1,2-dichloroethane, whereas less polar solvents promote the competing oxidation to generate the benzil; polar coordinating solvents such as tetrahydrofuran inhibited the reaction. The efficiency of the reaction is found to be dependent on nucleophile where an optimum of 30 equivalents of alcohol was observed. With electron-­donating substituents on the aromatic ring, the etherification was followed by oxidation to generate the benzil. Moderate yields of etherification product were obtained by monitoring the reaction progress with electron-rich substrates and quenching the reaction after two hours.
The intestinal mucosa as a target for dietary polyunsaturated fatty acids (2001)

Abstract Several studies have reported beneficial effects of dietary polyunsaturated fatty acids (PUFA) on various aspects of both human and animal health, and particular reference has been made to their effects on systemic immune responses. Both immune stimulation and immune suppression have been reported, with the outcome dependent on the type of PUFA, the target cell, as well as the immune competence of the cells before exposure. The systemic and the mucosal immune systems are discrete entities, which have evolved specific approaches in the defense of the host. The latter comprises several interconnected tissues, which communicate with one another through the action of soluble mediators and the trafficking of cellular components. After the oral mucosa, the intestinal epithelium and its associated gutassociated lymphoid tissue are the primary targets of dietary components. Absorption of dietary PUFA and its incorporation into intestinal tissues has been well studied, but the consequences of these events in relation to local immune responses have received little attention. This article describes some of the immune mechanisms operating at this barrier and, where possible, pinpoints areas for which a modulatory role for PUFA has already been demonstrated. Although not an exhaustive treatise of the subject, it is hoped that this review will foster research into the specific interaction between dietary PUFA and cell populations comprising the intestinal barrier.
Artificial Liver Devices and Bioartificial Liver Systems: Current Status (2011)

Acute liver failure is a rapidly progressive disease of the liver associated with high morbidity and mortality without liver transplantation. Although good survival after transplantation can be achieved, due to the disparity between patients awaiting transplantation and available organs, many patients die due to progression of the disease while waiting for a liver graft. To reduce the high morbidity and mortality associated with acute liver failure, attempts have been made during the last several decades to develop a temporary liver support system, such as artificial and bioartificial livers. The artificial liver is a non-biological device mainly aimed at the removal of accumulated toxins during liver failure, and the bioartificial liver is a biological device that has bioreactors containing living hepatocytes which provide both biotransformation and synthetic liver functions. There are currently 3 artificial livers available in the market that have been actively used in the clinical field, and 11 bioartificial livers that have been developed and have undergone clinical trials. In this article, we will discuss about the 3 artificial liver devices and 5 bioartificial liver systems that are the most advanced and have been widely evaluated clinically. Also, the characteristics and the preclinical data of the first bioartificial liver system developed in Korea that is currently under clinical investigation, will be discussed.
A Framework for Constraint-Based Deployment and Autonomic Management of Distributed Applications (2010)

We propose a framework for deployment and subsequent autonomic management of component-based distributed applications. An initial deployment goal is specified using a declarative constraint language, expressing constraints over aspects such as component-host mappings and component interconnection topology. A constraint solver is used to find a configuration that satisfies the goal, and the configuration is deployed automatically. The deployed application is instrumented to allow subsequent autonomic management. If, during execution, the manager detects that the original goal is no longer being met, the satisfy/deploy process can be repeated automatically in order to generate a revised deployment that does meet the goal.
ChemInform Abstract: Acidic Properties of (Dimethyl sulfoxide)(1,5‐diamino‐3‐azapentane)platinum(II) Perchlorate and Kinetics of the Displacement of Dimethyl Sulfoxide from the Conjugate Base. (1986)

Abstract The title complex is a weak acid (pKa = l 1.94 i 0.02 at 25°C and I = 0.10).
GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study (2011)

These preliminary results suggest that two boluses of 1500 IU hCG revert the luteolysis after a GnRHa trigger in the normo-responder patient. Importantly, no additional luteal support is needed. The novel concept combines the potential advantages of a physiological dual trigger (LH and FSH) with a simple, patient friendly, luteal support.
Optimistic Fair Secure Computation (Extended Abstract) (2000)

Abstract. We present an efficient and fair protocol for secure two-party computation in the optimistic model, where a partially trusted third party T is available, but not involved in normal protocol executions. T is needed only if communication is disrupted or if one of the two parties misbehaves. The protocol guarantees that although one party may terminate the protocol at any time, the computation remains fair for the other party. Communication is over an asynchronous network. All our protocols are based on efficient proofs of knowledge and involve no general zero-knowledge tools. As intermediate steps we describe efficient verifiable oblivious transfer and verifiable secure function evaluation protocols, whose security is proved under the decisional Diffie-Hellman assumption. 1
High‐Performance System Issues (2003)

This chapter includes the following topics: Absorbing Clock Uncertainties Time Borrowing Time Borrowing and Clock Uncertainty
Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review (2022)

Knowledge regarding the influence of the microbial community in cancer promotion or protection has expanded even more through the study of bacterial metabolic products and how they can modulate cancer risk, which represents an extremely challenging approach for the relationship between intestinal microbiota and colorectal cancer (CRC). This review discusses research progress on the effect of bacterial dysbiosis from a metabolic point of view, particularly on the biochemical mechanisms of butyrate, one of the main short chain fatty acids (SCFAs) with anti-inflammatory and anti-tumor properties in CRC. Increased daily intake of omega-3 polyunsaturated fatty acids (PUFAs) significantly increases the density of bacteria that are known to produce butyrate. Omega-3 PUFAs have been proposed as a treatment to prevent gut microbiota dysregulation and lower the risk or progression of CRC.
Microdialysis separately monitors myocardial interstitial myoglobin during ischemia and reperfusion (2005)

Direct monitoring of myoglobin efflux during ischemia and reperfusion has been limited because of inherent sample collection problems in the ischemic region. Recently, the cardiac dialysis technique has offered a powerful method for monitoring myocardial interstitial levels of low-molecular-weight compounds in the cardiac ischemic region. In the present study, we extended the molecular target to high-molecular-weight compounds by use of microdialysis probes with a high-molecular-mass cutoff and monitored myocardial interstitial myoglobin levels. A dialysis probe was implanted in the left ventricular free wall in anesthetized rabbits. The main coronary artery was occluded for 60 or 120 min. We examined the effects of myocardial ischemia and reperfusion on myocardial interstitial myoglobin levels. Interstitial myoglobin increased within 15 min of ischemia and continued to increase during 120 min of ischemia, whereas blood myoglobin increased at 45 min of ischemia. Lactate and myoglobin in the interstitial space increased during the same period. At 60 min of ischemia, reperfusion markedly accelerated interstitial myoglobin release. The interstitial myoglobin level was fivefold higher at 0-15 min of reperfusion than at 60-75 min of coronary occlusion. The dialysis technique permits earlier detection of myoglobin release and separately monitors myoglobin release during ischemia and reperfusion. Myocardial interstitial myoglobin levels can serve as an index of myocardial injury evoked by ischemia or reperfusion.
Hydrogen storage via polyhydride complexes (1996)

Polyhydride metal complexes are being developed for application to hydrogen storage. Complexes have been found which catalyze the reversible hydrogenation of unsaturated hydrocarbons. This catalytic reaction could be the basis for a low temperature, hydrogen storage system with a available hydrogen density greater than 7 weight percent. The P-C-P pincer complexes, RhH{sub 2}(C{sub 6}H{sub 3}-2,6-(CH{sub 2}PBu{sup t}{sub 2}){sub 2}) and IrH{sub 2}(C{sub 6}H{sub 3}-2,6-(CH{sub 2}PBu{sup t}{sub 2}){sub 2}) have unprecedented, long term stability at elevated temperatures. The novel iridium complex catalyzes the transfer dehydrogenation of cycloctane to cyclooctene at the rate of 716 turnovers/h which is 2 orders of magnitude greater than that found for previously reported catalytic systems which do not require the sacrificial hydrogenation of a large excess of hydrogen acceptor.