gebhart/patrepeval huggingface dataset:
New Design Models and Materials Provide Engineered Solutions to Lost Circulation (2006)

Abstract The prevention and remediation of lost circulation during well construction employs engineered solutions that require a menu of services and tools to support the planning and application stages. Specialty software is used during the planning stage leading to the application of unique products and systems during the delivery stage. A feasibility study by technology specialists may include a wide range of tools during the planning stage to support data acquisition, modeling and design of the application stage. Planning services include hydraulics and fracture characterization modeling to assess expected Equivalent Circulating Densities (ECD) and their effect on potential lost circulation intervals. The fracture characterization modeling for borehole stress treatments uses a module that calculates both the expected fracture width and the particle size distribution required to plug the induced fracture and prevent propagation. The effect of these additions on the rheology of a non-aqueous drilling fluid can then be determined by the use of a new predictive rheology model. Application services may include real-time data acquisition to support delivery of specialized lost circulation materials and systems in either a preventive (pretreatment and/or borehole stress treatments to strengthen the wellbore) or corrective mode (mitigating lost circulation and, where possible, providing additional wellbore strength).
Probing the Mint2 Protein–Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease (2018)

Abstract The intracellular adaptor protein Mint2 binds amyloid precursor protein (APP) and presenilin‐1, which are both central constituents of the amyloidogenic pathway associated with Alzheimer's disease (AD). Additional interaction partners have also been suggested for Mint2; several of them are also pertinent to AD pathogenesis. However, no comparative mapping of the Mint2 protein–protein interaction network is available. Here we provide a systematic characterization of seven interaction partners and address their specificities towards the different binding domains of Mint2, which reveal domain‐specific and ‐nonspecific interaction partners. Moreover, we show that the last two C‐terminal amino acids of Mint2 are both important for the intramolecular interaction with the PDZ1 domain and for the stability of Mint2.
A 14 nm 1.1 Mb Embedded DRAM Macro With 1 ns Access (2015)

A 1.1 Mb embedded DRAM macro (eDRAM), for next-generation IBM SOI processors, employs 14 nm FinFET logic technology with 0.0174 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> deep-trench capacitor cell. A Gated-feedback sense amplifier enables a high voltage gain of a power-gated inverter at mid-level input voltage, while supporting 66 cells per local bit-line. A dynamic-and-gate-thin-oxide word-line driver that tracks standard logic process variation improves the eDRAM array performance with reduced area. The 1.1 Mb macro composed of 8 ×2 72 Kb subarrays is organized with a center interface block architecture, allowing 1 ns access latency and 1 ns bank interleaving operation using two banks, each having 2 ns random access cycle. 5 GHz operation has been demonstrated in a system prototype, which includes 6 instances of 1.1 Mb eDRAM macros, integrated with an array-built-in-self-test engine, phase-locked loop (PLL), and word-line high and word-line low voltage generators. The advantage of the 14 nm FinFET array over the 22 nm array was confirmed using direct tester control of the 1.1 Mb eDRAM macros integrated in 16 Mb inline monitor.
A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases (2019)

This was a systematic review of the literature on the association between obesity and the outcome of inflammatory rheumatic diseases. We conducted a literature search using PubMed®, Embase and PsycINFO®. Articles were classified into three categories based on the effects of obesity on the outcomes of inflammatory rheumatic diseases. The subject population, country, type of studies, number of patients, measurement of obesity and outcomes assessed were presented. Quality was appraised using Kmet et al's criteria. 4,331 articles were screened and 60 were relevant to the objective. Obesity had a negative, positive and neutral association with outcomes of inflammatory rheumatic diseases in 38 (63.3%) studies with 57,612 subjects, 11 (18.3%) studies with 3,866 subjects, and 11 (18.3%) studies with 3,834 subjects, respectively. In most studies, the disease population had been diagnosed with rheumatoid arthritis (RA). Tumour necrosis factor-α inhibitors were mostly associated with negative outcomes. More studies examining subjects outside Europe and North America and diseases other than RA are warranted.
Optical and Thermal Characteristics of Nd:LuVO4Grown by Floating Zone Method (2009)

High-quality Nd:LuVO4 crystals were successfully grown by the floating zone method. Broadband fluorescence with a full width at half maximum of 10 nm at approximately 1066 nm was observed upon σ-polarization. A maximum slope efficiency of 72% was achieved in the case of pumping at 880 nm for 1066 nm laser generation. Furthermore, we measured the thermal diffusivity of the Nd:LuVO4 crystal by temperature wave analysis. By applying this method, the variation of the measured results was improved from 10 to 2%. The thermal conductivity of a 1.0 at. % Nd-doped LuVO4 crystal was 6.1 W/mK in the [110] direction.
Specific energy for laser removal of rocks (2001)

Application of advanced high power laser technology into oil and gas well drilling has been attracting significant research interests recently among research institutes, petroleum industries, and universities. Potential laser or laser-aided oil and gas well drilling has many advantages over the conventional rotary drilling, such as high penetration rate, reduction or elimination of tripping, casing, and bit costs, and enhanced well control, perforating and side-tracking capabilities. The energy required to remove a unit volume of rock, namely the specific energy (SE), is a critical rock property data that can be used to determine both the technical and economic feasibility of laser oil and gas well drilling. When a high power laser beam is applied on a rock, it can remove the rock by thermal-spallation, melting or vaporization depending on the applied laser energy and the way the energy is applied. The most efficient rock removal mechanism would be the one that requires the minimum energy to remove a unit volume of rock. First, studies were carried out to investigate the correlation between the rock removal mechanisms and laser processing parameters. Then the test matrixes were carefully designed and performed based on the established correlation to quantitatively determine the nearly true specific energy. A 1.6 kW pulsed Nd:YAG laser, with a unique control capacity over laser parameters, is utilized to perform beam application tests on the rocks. The effect of laser processing parameters, such as beam irradiance, energy per pulse, exposure time, and pulse repetition rate, on the removal of rocks are investigated. The study found that different laser-rock interaction zones from intense melting to scorching could be produced in the rock depending on the applied beam irradiance and exposure time. However, the most efficient rock removal mechanism was found to be thermal-spallation where the rock was thermally fractured and removed from the hole before any further melting or vaporizing (which requires much higher energy). The study also found that increasing beam repetition rate within the same material removal mechanism would increase the material removal rate due to an increase of maximum temperature, thermal cycling frequency, and intensity of laser-driven shock wave within the rock.
Analysis of recovery in radiation-induced loss in rare-earth-doped fibers through master curve/demarcation energy diagrams (2003)

Radiation-induced losses in rare-earth-doped fibers are analyzed in a novel manner. The mastercurve approach is used for analyzing stability of defects induced by radiation. This method can be applied to examine fibers for space applications.
ChemInform Abstract: Dendrimer Therapeutics: Covalent and Ionic Attachments (2012)

Abstract Review: 95 refs.
Mitofusin2 Mutations Disrupt Axonal Mitochondrial Positioning and Promote Axon Degeneration (2012)

Alterations in mitochondrial dynamics (fission, fusion, and movement) are implicated in many neurodegenerative diseases, from rare genetic disorders such as Charcot-Marie-Tooth disease, to common conditions including Alzheimer's disease. However, the relationship between altered mitochondrial dynamics and neurodegeneration is incompletely understood. Here we show that disease associated MFN2 proteins suppressed both mitochondrial fusion and transport, and produced classic features of segmental axonal degeneration without cell body death, including neurofilament filled swellings, loss of calcium homeostasis, and accumulation of reactive oxygen species. By contrast, depletion of Opa1 suppressed mitochondrial fusion while sparing transport, and did not induce axonal degeneration. Axon degeneration induced by mutant MFN2 proteins correlated with the disruption of the proper mitochondrial positioning within axons, rather than loss of overall mitochondrial movement, or global mitochondrial dysfunction. We also found that augmenting expression of MFN1 rescued the axonal degeneration caused by MFN2 mutants, suggesting a possible therapeutic strategy for Charcot-Marie-Tooth disease. These experiments provide evidence that the ability of mitochondria to sense energy requirements and localize properly within axons is key to maintaining axonal integrity, and may be a common pathway by which disruptions in axonal transport contribute to neurodegeneration.
Abstract 2309: Chimeric antigen receptor T-cell therapy targeting glypican-1 in pancreatic cancer (2019)

Abstract Pancreatic cancer is the fourth most common cause of death from cancer in the US, with a 5-year overall survival of 8.5%. While immunotherapy with chimeric antigen receptor (CAR) T cells has shown promise in certain hematological malignancies, their efficacy for solid tumors including pancreatic cancer remains elusive. Thus, laboratory research is urgently needed to identify and validate a new target of CAR T-cell therapy for patients with pancreatic cancer. In this study, we made CAR T cells that recognize glypican-1 (GPC1), a cell surface heparan sulfate proteoglycan protein that is overexpressed in pancreatic cancer. We isolated two GPC1-specific antibodies; the mouse monoclonal antibody HM2 that binds the C-lobe of GPC1 close to the cell surface, and the camel single domain antibody D4 that recognizes a conformational epitope in the protein core of GPC1. The transduction efficiencies of CAR (HM2) and CAR (D4) in primary T cells were 86% and 58%, respectively. GPC1-overexpressing KLM1 cells (2B9) and GPC1-overexpressing A431 cells (H8) were efficiently lysed by both CAR T cells in dose-dependent manners. By contrast, minimal cell lysis was observed in GPC1-negative cell line A431. In the presence of GPC1-positive tumor cells, greater amount of TNF-α, IFN-γ and IL-2 were produced by GPC1-specific CAR T cells than mock-transduced T cells. Although both CAR T cells showed similar cytolytic activity in vitro, CAR (D4) T cells induced 2-4 times more cytokines than CAR (HM2) T cells when co-cultured with GPC1-postive tumor cells. Notably, both GPC1-targeted CAR T cells demonstrated potent antitumor efficacy in a peritoneal dissemination xenograft mouse model. Our findings indicate that GPC1-targeted CAR T cell therapy could be a new approach for treating pancreatic cancer. Citation Format: Nan Li, Dan Li, Hua Ren, Madeline Torres, Mitchell Ho. Chimeric antigen receptor T-cell therapy targeting glypican-1 in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2309.
Dynamics of ArF excimer laser-induced cavitation bubbles in gel surrounded by a liquid medium (1997)

Single laser pulses did not cause disruption of gelatin at an energy fluence of up to 0.4 J/cm2/pulse. During the application of repetitive pulses small insoluble gas-containing bubbles were produced and often trapped between the tip and the tissue. They completely changed the shape of the subsequent cavitation bubbles and caused deep crater formation in the gel.
Convergence Analysis Of The Ε Nsrlmmn Algorithm (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Minority Carrier Disturb in Thyristor Memory Arrays and a Novel Cell Design for High Density DRAM (2017)

Inter-cell disturb from minority carriers is found to be one of the major problems for scaling cross-point vertical Thyristor arrays. Cell designs with minority carrier lifetime killers and deep trench isolations are either ineffective or difficult to manufacture. This paper discloses a novel MBW-VLT cell that achieves a 5F2 bit cell area, is compatible with existing DRAM fabrication tools, and devoid of any minority carrier disturbance. A well calibrated TCAD simulator is used to fully verify both DC and AC operations of cell strings.
Microstructure and oxide particle stability in a novel ODS γ-TiAl alloy processed by spark plasma sintering and laser additive manufacturing (2017)

In this work, a novel oxide dispersion strengthened titanium aluminide alloy (Ti-45Al-3Nb-<0.2Y2O3 at.%) was developed for powder-based processing technologies with a focus on spark plasma sintering and additive manufacturing. Titanium aluminides are promising structural intermetallics for weight reduction and an increased performance of high temperature components. The alloy design and selection process was supported by computational thermodynamics based on the CALPHAD approach, taking into account requirements for processing as well as long term alloy behavior under service conditions. Processing trials using spark plasma sintering, direct metal deposition and selective laser melting were conducted to study the alloy behavior, microstructure formation and introduction as well as stability of the ODS particles. Additionally, thermal annealing on the sintered and laser consolidated material was performed. Conventional dual phase α2-Ti3Al and γ-TiAl duplex and near-lamellar microstructures were obtained from the processed material. The ODS particles were homogeneously distributed in the alloy matrix after processing in the liquid state. For the direct metal deposition process, the novel alloy was compared to the established GE48-2-2 alloy (Ti-48Al-2Cr-2Nb) in terms of phases, microstructure and texture after processing. A significantly reduced texture formation was observed with the novel alloy. The hardness of the consolidated material shows superior properties for ODS-containing TiAl compared to ODS-free material. This work provides a first step towards tailored alloys for AM and the production of ODS TiAl alloys.
Reporter‐Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis (2020)

Most natural product biosynthetic gene clusters that can be observed bioinformatically are silent. This insight has prompted the development of several methodologies for inducing their expression. One of the more recent methods, termed reporter-guided mutant selection (RGMS), entails creation of a library of mutants that is then screened for the desired phenotype via reporter gene expression. Herein, we apply a similar approach to Burkholderia thailandensis and, using transposon mutagenesis, mutagenize three strains, each carrying a fluorescent reporter in the malleilactone (mal), capistruin (cap), or an unidentified ribosomal peptide (tomm) gene cluster. We show that even a small library of <500 mutants can be used to induce expression of each cluster. We also explore the mechanism of activation and find that inhibition of pyrimidine biosynthesis is linked to the induction of the mal cluster. Both a transposon insertion into pyrF as well as small-molecule-mediated inhibition of PyrF trigger malleilactone biosynthesis. Our results pave the way toward the broad application of RGMS and related approaches to Burkholderia spp.
[Hemodynamic concomitant effects of experimentally increased pulmonary capillary pressure]. (1976)

An acute suprarenal occlusion of the aorta was produced in anaesthetized dogs by means of a ballon-tipped catheter. The resultant increase in wedge-pressure led to changes in pulmonary perfusion and raised O2 partial pressure in the arterial blood. The additional, simultaneous occlusion of the left subclavian artery by means of a second balloon-tipped catheter aggravated the haemodynamic manifestations of the pressure-load on the heart; but did not cause a proportionate increase in wedge pressure and O2 partial pressure.
ChemInform Abstract: EFFECTS OF IONIZING RADIATION ON DEOXYRIBONUCLEIC ACID AND RELATED SYSTEMS. PART 1. THE ROLE OF OXYGEN (1984)

Abstract Unter γ‐Strahleneinwirkung bildet DNA in wäßriger Lösung bei 77 K Guanidinkationen und protonierte Thyminanionen (I) zu etwa gleichen Teilen.
Closed-loop system identification of cardiovascular control mechanisms in diabetic autonomic neuropathy (1995)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
Characterization of the growths of UV-induced birefringence in effective mode index and index modulation in fiber Bragg gratings (2005)

The ultraviolet-induced polarization-mode dispersion and polarization-dependent loss of fiber Bragg gratings in single-mode fibers (SMF-28) are characterized in a real-time and in situ fashion during grating inscription. For the first time, the growths in birefringence of both the effective mode index and the index modulation are presented.
3D sound field recording and reproducing system including sound source orientation (2010)

To achieve ultra-realistic communications (URC), a three-dimensional (3D) sound field recording and reproducing system using spatial sound features is promising. It utilizes sound source positions and original source signals as features. On the other hand, sound source orientations (such as speaker's orientation) have been neglected, though they are necessary for high-performance URC. In this paper, we propose a 3D sound field recording and reproducing system that includes sound source orientation. For the recording part, we applied and evaluated a sound source orientation estimation method based on orientation-extended beamforming. This method requires transfer functions for all possible source positions and orientations, which should be either measured or calculated. Measured transfer functions have high accuracy because all characteristics, such as reverberations and diffractions, are taken into account. Calculated transfer functions are obtained for any environment without measurements. We performed experiments to evaluate the orientation estimation method using transfer functions obtained by both practical measurements and calculations using acoustic simulation based on wave theory. The experimental results show that our estimation method has sufficient capability using both measured and calculated transfer functions. For the reproducing part, we evaluated impulse responses versus sound source orientation. The evaluation results revealed significant differences in both objective and subjective scores. This proves that our system achieves higher performance than conventional ones that do not utilize orientation features.
Carbohydrates selectively protect a specific domain of fibronectin against proteases. (1982)

To determine how the carbohydrate moiety of fibronectin influences the susceptibility of protein to proteolytic degradation, we compared the effects of various proteases on glycosylated and nonglycosylated fibronectins. Nonglycosylated fibronectin, from tunicamycin-treated chicken embryo fibroblasts, was degraded more rapidly to acid-soluble products than glycosylated fibronectin by pronase, thermolysin, trypsin, and chymotrypsin. The absence of carbohydrate did not markedly affect overall patterns of proteolytic fragments identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Except for the expected increases in electrophoretic mobilities of the nonglycosylated peptides, the only important difference was that of the nonglycosylated fragment corresponding to the carbohydrate-rich, collagen-binding domain, was completely digested by the proteases in 60 min at 30 degrees C. In contrast, the comparable fragment from glycosylated fibronectin was resistant to protease digestion. Heparin-binding domains that normally lack carbohydrate are equally susceptible to proteases in glycosylated and nonglycosylated fibronectin. We conclude that the carbohydrate component of fibronectin plays an important role in the stabilization of a specific domain of the protein against proteolytic degradation; however, the carbohydrate does not alter overall proteolytic specificity.
ChemInform Abstract: SYNTH. PHENYLIERTER PHTHALIMIDE, DIE DIELS‐ALDER‐RK. VON TETRAPHENYLCYCLOPENTADIENON MIT MALEINIMIDEN (1973)

Abstract Tetraphenylcyclopentadienon (I) reagiert mit Maleinimid (IIa), N‐Phenyl‐maleinimid (IIb) sowie den Bis‐imiden (V) zu den Addukten (III) bzw. (VI), die in Nitrobenzol oder durch Brom zu den Phthalimiden (IV) bzw. (VII) aromatisiert werden.
Cost-Effective Mission Assurance Engineering Through Simulation (2021)

Cyber-physical systems have witnessed fantastic leaps in their capabilities, thanks to advances in artificial intelligence and machine learning. With these great capabilities, however, should come great assurance that they will behave as expected. For example, an autonomous vehicle (AV) must protect passengers, bystanders, property and itself. Safety alone is insufficient, however. The AV is built for a mission, and mission assurance must also be addressed, i.e., getting the AV’s job done despite foreseen and unforeseen circumstances. Mission assurance should begin as far left in the engineering lifecycle as possible, ideally before the first vehicle is assembled. If the many hours of operational experience that familiarize system builders and operators with the vehicle’s performance and potential risky behaviors could be accrued through simulation, rather than expensive prototypes, a better vehicle can be developed at significantly less cost. The purpose of this paper is to demonstrate the value of cost-effective open-source based simulation in exercising and analyzing AV algorithms. Our results with DESCRETE, a testbed we developed for engineering mission assurance in the maritime domain, show that sufficient fidelity can be realized practically in the lab for unforeseen, but realistic, situations to arise and be examined in a more controlled and less costly environment. Collision avoidance algorithms, for example, must consider complex interactions between multiple vehicles, trading off safety for mission efficiency. Our experimental results demonstrate the interplay between these two competing goals, and help inform what to deem appropriately safe by both eliminating the obviously unsafe situations and identifying what might be too safe, which necessitates either accepting some risks or changing the mission to avoid them.
200 Gbit/s 16QAM WDM Transmission over a Fully Integrated Cladding Pumped 7-Core MCF System (2017)

A complete, realistic integrated system is investigated, consisting of directly spliced 7-core MCF, cladding-pumped 7-core amplifiers, isolators, and couplers. The system is demonstrated in a 16QAM C-band WDM scenario over 720 km.