gebhart/patrepeval huggingface dataset:
Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones} (2008)

Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives. In particular, 5-aminooxazolo[5,4-d]pyrimidine-7(6H)-ones (9-oxa-guanines) have been shown to inhibit ricin. The preparation of a series of 2-substituted 5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones and related 5-thio-oxazolo[5,4-d]pyrimidines is described, including analogs suitable for further elaboration employing "click" chemistry utilizing copper-catalyzed Huisgen 1,3-dipolar cycloadditions. Two of the compounds prepared were found to inhibit ricin with IC(50)ca. 1-3 mM.
Short range order in bimetallic nanoalloys: An extended X-ray absorption fine structure study (2013)

Partial coordination numbers measured by extended X-ray absorption fine structure (EXAFS) spectroscopy have been used for decades to resolve between different compositional motifs in bulk and nanoscale bimetallic alloys. Due to the ensemble-averaging nature of EXAFS, the values of the coordination numbers in nanoparticles cannot be simply interpreted in terms of the degree of alloying or segregation if the compositional distribution is broad. We demonstrate that a Cowley short range order parameter is an objective measure of either the segregation tendency (e.g., a core-shell type) or the degree of randomness (in homogeneous nanoalloys). This criterion can be used even in the case when the clusters are random but have broad compositional distributions. All cases are illustrated using the analyses of EXAFS data obtained in three different nanoscale bimetallic systems: Pt(core)-Pd(shell), Pd(core)-Pt(shell), and Pt-Pd random alloy.
Compensation method for quantitative observation of multicolor fluorescence with nonlinear mapping (2008)

In the field of biology, compensation of multiple fluorescence is necessary for quantitative measurement of samples. Conventional methods depend on a linear combination model irrespective of the model's adequacy. Therefore, proper compensation has not been performed in some situations. To overcome this problem, we propose a method for performing nonlinear mapping with emphasis on the distribution of samples on a plane of which the base vectors are references of fluorescence. This paper describes an experiment with measurement of multiple fluorescence and compensation using a conventional method and our proposed method. Results show that multiple fluorescence is not always able to assume a linear combination model. Moreover, we confirmed that the presented method is independent of linearity of multiple fluorescence.
Centimeter-scale super-collimation in a large-area 2D photonic crystal (2006)

We studied super-collimation in a planar 2D photonic crystal at 1.5 μm wavelengths and observed an inherent robustness to short-scale disorder. A 2 μm-wide beam was propagated over more than 0.5 cm without diffraction.
Mechanical Properties of Mild Steel Weld Metals Produced in Pressurized Ar-Co2 Atmospheres. (1991)

Mild steel sheets with V-groove were welded in pressurized Ar-CO2 gas mixture atmospheres up to 2.0 MPa, using a 1.6 mm diameter solid wire. The effect of ambient gas pressure and gas composition on the mechanical properties of weld metals were studied. The Vickers hardness and tensile properties of weld metals were varied with the ambient gas composition but did not depend on the ambient gas pressure. The Charpy V notch toughness of weld metal was changed markedly with CO2 partial pressure in the atmosphere, and showed a maximum at 0.1-0.2 MPa CO2 partial pressure which resulted in about 0.03% oxygen content of weld metal having a fine ferrite microstructure. This suggests that toughness is strongly influenced by the oxygen content of weld metal. Mechanical properties of pressurized steel weld metal can be controlled by CO2% in the welding atmosphere, because the oxygen content of weld metal is determined by CO2 partial pressure.
Pruritus is associated with severely impaired quality of life in patients with primary sclerosing cholangitis (2014)

Pruritus severely affects quality of life in patients with primary sclerosing cholangitis and is associated with depression to varying extents, although the most commonly used parameters of disease severity do not correspond to quality of life in these patients. These findings need to be considered with respect to treatment outcomes and indications for liver transplantation.
Mixed Differential Privacy in Computer Vision (2022)

We introduce AdaMix, an adaptive differentially private algorithm for training deep neural network classifiers using both private and public image data. While pre-training language models on large public datasets has enabled strong differential privacy (DP) guarantees with minor loss of accuracy, a similar practice yields punishing trade-offs in vision tasks. A few-shot or even zero-shot learning baseline that ignores private data can outperform fine-tuning on a large private dataset. AdaMix incorporates few-shot training, or cross-modal zero-shot learning, on public data prior to private fine-tuning, to improve the trade-off. AdaMix reduces the error increase from the non-private upper bound from the 167–311% of the baseline, on average across 6 datasets, to 68-92% depending on the desired privacy level selected by the user. AdaMix tackles the trade-off arising in visual classification, whereby the most privacy sensitive data, corresponding to isolated points in representation space, are also critical for high classification accuracy. In addition, AdaMix comes with strong theoretical privacy guarantees and convergence analysis.
Consortium of otolaryngology journal editors: Collegiality and contributions (2020)

None to declare.
CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes. (1993)

The role of costimulation in the activation of TCR-gamma delta cells in normal mice and mice transgenic (tg) for a TCR-gamma delta receptor was investigated. Activation of TCR-gamma delta cells required two signals. One signal was mediated by TCR occupancy, whereas a second signal was provided by accessory cells. The importance of the CD28/B7 interaction in the delivery of the second signal was demonstrated in multiple ways. First, addition of a soluble fusion protein homolog of CD28, CTLA4Ig, significantly inhibited the activation of G8 tg splenic TCR-gamma delta lymphocytes and intestinal epithelial TCR-gamma delta lymphocytes by Ag-bearing lymphocytes during primary stimulation. Similarly, both proliferation and IFN-gamma production were inhibited by addition of CTLA4Ig to secondary antigenic stimulation of G8 tg TCR-gamma delta cells. Second, an Ag-bearing thymoma, EL-4, was only able to stimulate expanded G8 tg TCR-gamma delta cells when the thymoma expressed B7. This stimulation was blocked by both CTLA4Ig and anti-B7 antibody. Third, antibodies to CD28 were able to mimic the costimulatory affect of APC. TCR-gamma delta cells cultured with either Ag-bearing fixed stimulator cells or submitogenic concentrations of immobilized anti-pan TCR-gamma delta mAb proliferated only in the presence of anti-CD28 mAb. Finally, G8 tg cells produced IL-2 only in the presence of APC costimulation or anti-CD28 antibodies, and the addition of exogenous rIL-2 overcame the need for costimulation. Thus, autocrine IL-2 production is one of the major consequences of TCR-gamma delta cell costimulation. Together these data demonstrate that costimulation is necessary for the activation of TCR-gamma delta cells and can occur through CD28 interaction.
Polymer supported carbon for safe and effective remediation of PFOA and PFOS-contaminated water (2019)

&lt;div&gt; &lt;div&gt; &lt;div&gt; &lt;p&gt;Powdered activated carbon (PAC) is an economical sorbent for removing micropollutants from water, but it generates hazardous dust that is flammable and a respiration hazard. Additionally, the fine particles of PAC can cake and block filters and membranes, complicating its use in continuous processes. In this study, we present a sulfur polymer support for PAC that overcomes these problems. The blend of the sulfur polymer and PAC generates low dust and it does not block filters. The utility of the sorbent is demonstrated in the remediation of water contaminated with perfluorinated alkyl substances (PFASs)—persistent micropollutants that currently threaten water safety worldwide. Fundamental discoveries of PFAS self-assembly are reported, as well as testing on field samples. &lt;/p&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;
Block‑Removed Immunoglobulin Technology to enhance rituximab effector function by counteracting CA125‑mediated immunosuppression (2021)

Rituximab (RTX) is a CD20-targeting antibody that is the standard-of-care for patients with non-Hodgkin Lymphoma (NHL) cases. RTX's mechanism of action includes complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Recent clinical evidence suggests that high serum levels of the tumor-produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. The present study sought to understand the possible mechanism underlying these results; therefore, cellular and molecular analyses of RTX and CA125 interaction were peformed, and a library of RTX variants was generated using a proprietary technology called Block-Removed Immunoglobulin Technology that combines randomized amino acid substitutions and high-throughput functional screenings to identify CA125-refractory RTX variants. The present study demonstrated that CA125 could bind to RTX and reduce its tumor cell killing activity. Furthermore, the study characterized an RTX variant, named NAV-006 (RTX-N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. Taken together, these findings warranted further investigation on NAV-006 as a next generation anti-CD20 antibody that could improve the efficacy of parent RTX in NHL patients with high levels of CA125.
Application of the ESMACS Binding Free Energy Protocol to a Highly Varied Ligand Dataset: Lactate Dehydogenase A (2019)

Here, we evaluate the performance of our range of ensemble simulation based binding free energy calculation protocols, called ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) for use in fragment based drug design scenarios. ESMACS is designed to generate reproducible binding affinity predictions from the widely used molecular mechanics Poisson-Boltzmann surface area (MMPBSA) approach. We study ligands designed to target two binding pockets in the lactate dehydogenase A target protein, which vary in size, charge and binding mode. When comparing to experimental results, we obtain excellent statistical rankings across this highly diverse set of ligands. In addition, we investigate three approaches to account for entropic contributions not captured by standard MMPBSA calculations: (1) normal mode analysis, (2) weighted solvent accessible surface area (WSAS) and (3) variational entropy.
A Statistical Model for Extracting Geometric Sources of Transistor Performance Variation (2004)

This paper provides an approach to extracting geometrical variations in nominally identical devices fabricated in close proximity to each other. The method assumes correlations between factors can be neglected. With this assumption, it is shown that geometrical variations are significant, and any study of microscopic variations, such as dopant fluctuations, must first strip away these macroscopic geometrical variations. We assess the gate length L and width W dependence of threshold voltage (V/sub T/) variations. Related geometrical variations, namely corner influences where the source and drain encounter the isolation edges are examined, and incorporated in the model. Results from the model are compared to measurements at small dimensions. The differences provide lower bounds for excess variations other than these geometrical contributions. Our study shows that these other variations account for almost half the total V/sub T/ variance at the smallest device size fabricated, demonstrating the seriousness of these other variations when scaling down devices.
Effects of High-Temperature Annealing on Operation Characteristics of a-In-Ga-Zn-O TFTs (2014)

We report operation characteristics of amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs) annealed in dry O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> at temperatures up to 700 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C. The largest TFT mobilities were obtained by annealing at 200 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C-300 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C and the smallest subthreshold voltage swing ( S) was obtained at 200 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C, while those annealed at higher T exhibited poorer mobilities and S values. The TFTs annealed at ≥ 600 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C were crystallized and exhibited further poorer characteristics probably due to grain boundary issues; while, the deterioration by the 400 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C-500 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C annealing is attributed to depletion of hydrogen and consequent de-passivation effects. Device simulations and photoresponse spectroscopy extracted systematic variation of trap densities in the a-IGZO layer.
Use of a Shack–Hartmann wave-front sensor to measure deviations from a Kolmogorov phase spectrum (1995)

Experimental results indicate that the statistics of phase measured across a telescope aperture do not always obey the power laws associated with the Kolmogorov model of atmospheric turbulence. We show that the statistical relations between a wave front and its aperture-averaged first derivative previously derived for a Kolmogorov spectrum can be easily generalized for any power law. We also show that a Shack–Hartmann sensor can be used to measure the form of the structure function of phase fluctuations, and experimental data are presented.
Voltammetric Behaviour of CRE-319, A Novel Dihydropyridine Calcium Antagonist and Its Polarographic, UV Spectrophotometric and HPLC Determination (1992)

Abstract CRE-319, a novel 1, 4-dihydropyridine derivative, produces a cathodic polarographic peak due to the reduction of its nitro group according to the following well-known general pathway for the nitro group: The electrode mechanism is strongly dependent on the pH of the solution and follows a similar behaviour to that previously reported for nitrobenzene. The peak current shows a linear dependence with CRE-319 concentrations. This behaviour is used for analytical purposes in determining CRE-319 content in solution. In order to obtain comparative results, we have also developed a spectrophotomebic and an HPLC method for quantifying CRE-3 19.
DFT calculation of oxygen adsorption on platinum nanoparticles: coverage and size effects (2018)

Catalysts made of Pt nanoparticles and Pt alloys are considered state-of-the-art catalysts for the anodic and cathodic reactions involved in hydrogen fuel cells. The optimal size of such nanoparticles for each chemical reaction is an unsolved problem that depends on environmental variables, such as reactant concentration, solvent, temperature, etc. From a theoretical point of view, this problem has been tackled mainly by observing how single key adsorbates react with different nanoparticles under controlled conditions. In this work, we use large-scale DFT calculations to examine the interplay between the Pt nanoparticle size and O coverage effects. We examine single O adsorptions for three adsorption sites on cuboctahedral platinum nanoparticles with different sizes. As we grow the nanoparticle size, the binding strength decreases and we observed a quick convergence of the adsorption energies with increasing nanoparticle size, which correlates with the calculated d-band centre for (111) Pt facets on such nanoparticles. We also carried out a detailed study of the effect of oxygen coverage with varying fractions of O monolayer coverage, computing adsorption energies per O atom for Pt55, Pt147 and Pt309 nanoparticles with several O coverages. In general, an increase of O coverage led to weaker adsorption energies per O atom, and when analysing the results in terms of oxygen monolayers, this effect is more pronounced for larger nanoparticles. The O coverage dependency of the adsorption energy per O atom is analysed in terms of the O distribution for each nanoparticle size and electronic changes that the adsorbed oxygen causes to the Pt nanoparticle. In studying nanoparticle size and oxygen coverage effects simultaneously, we offer insights with DFT accuracy to help on heterogeneous catalyst design.
Hybrid Mode Locked Fiber Laser Using a PDMS/SWCNT Composite Operating at 4 GHz (2011)

A hybrid mode-locked Erbium-doped fiber laser that provides very short pulse-widths while achieving high repetition rates is proposed and experimentally demonstrated. This hybrid configuration is realized by using a thin film of polydimethylsiloxane (PDMS) doped with single wall carbon nanotubes (SWCNT). This PDMS/SWCNT composite acts as a saturable absorber and is inserted within an active mode-locked laser system using angled connectors. Therefore, the effect of the PDMS/SWCNT composite is to effectively narrow the width of the pulses generated by the active system without modifying its repetition rate. A pulse-width of 730 fs was generated at a repetition rate of 4 GHz, while achieving an average output power of 4 mW. A reduction in the noise of the photodetected RF spectrum was also observed in the hybrid system.
Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor (2019)

The emission of Cherenkov photons from human and animal tissue can be observed during clinical x-ray or particle beam irradiation. However, imaging this weak emission with the necessary single-photon sensitivity in the clinical room is challenging because of milliwatt-level ambient room lighting and the presence of stray high-energy radiation. In this Letter, we demonstrate, to the best of our knowledge, the first Cherenkov imaging with a time-gated quanta image sensor employing a large single-photon avalanche diode (SPAD) array. Detecting single Cherenkov photons was possible with high photon avalanche gain, fast temporal gating, and moderately high ∼7% photon detection probability. Single-bit digitization and active SPAD quenching enabled stray x-ray noise suppression and photon-noise-limited imaging in a clinical environment. This type of imaging allows the knowledge of location, shape, and surface dose of the therapeutic beam radiotherapy with the stability of solid state-based detection.
Improving teleoperation performance in the presence of non-ideal robot dynamics (2008)

The use of thin and lightweight arms and cable-driven end-effectors in space and surgical manipulators introduces link and/or joint flexibility. When such manipulators are used as the slave robot of a master-slave teleoperation system, teleoperation performance can be degraded. We report a comparison of teleoperation system performances under slave robot link and joint flexibility (tool flexibility). We also evaluate the added benefits of using extra sensors at the tip of the flexible slave robot. It is reported that tip velocity (or position) feedback improves free-space position tracking performance in the presence of robot flexibility. Also, when the interaction forces with an environment are measured by a force sensor and fed back to the userpsilas hand, tip velocity feedback improves hard-contact force tracking performance. During a hard contact task, tip velocity feedback can also eliminate the transmission of robot flexibility to the userpsilas hand.
Aerodynamics of a Transonic Centrifugal Compressor Impeller (2002)

High pressure ratio centrifugal compressors are applied to turbochargers and turboshaft engines because of their small dimensions, high efficiency and wide operating range. Such a high pressure ratio centrifugal compressor has a transonic inlet condition accompanied with a shock wave in the inducer portion. It is generally said that extra losses are generated by interaction of the shock wave and the boundary layers on the blade surface. To improve the performance of high pressure ratio centrifugal compressor it is necessary to understand the flow phenomena. Although some research works on transonic impeller flow have been published, some unknown flow physics are still remaining. The authors designed a transonic impeller, with an inlet Mach number is about 1.3, and conducted detailed flow measurements by using Laser Doppler Velocimetry (LDV). In the result the interaction between the shock wave and tip leakage vortex at the inducer and flow distortion at the downstream of inducer were observed. The interaction of the boundary layer and the shock wave was not observed. Also computational flow analysis were conducted and compared with experimental results.
Simulations without critical slowing down: Ising and three-state Potts models (1989)

We have developed a novel simulation method that combines a multigrid technique with a stochastic blocking procedure. Our algorithm eliminates critical slowing down completely, as we demonstrated previously by simulating the two-dimensional Ising model at criticality. Here we describe results of much more extensive simulations of the two-dimensional Ising and three-state Potts models and provide a heuristic argument to explain why our method works.
Single and multi-cell scheduling in coordinated multi-point distributed antenna systems (2012)

Multi-cell coordination is a technique for interference mitigation in cellular systems. For joint-transmission (JT), the received signal power is boosted by diversity combining of signals from multiple transmission points. This however results in reduced frequency-reuse ratio and cell-splitting order, which may subsequently degrade the network-level throughput. In order to strike a balance between the diversity combining gain and frequency-reuse ratio, in this paper we propose a dynamic scheduling algorithm that adaptively schedules users in single-cell or multi-cell transmission mode to maximize the system sum throughput. Furthermore, basestation association for each user is meticulously addressed to avoid negatively impacting the frequency-reuse gain. The proposed algorithm is evaluated with system-level evaluation tools fully compliant with 3GPP LTE specification, thereby providing a realistic assessment on the gain of multi-cell coordination in terms of system capacity and coverage.
Boundaries of Parametric Gain due to Four-wave Mixing in Hybrid Photonic Crystal Fibers (2014)

Parametric gain by four-wave mixing is considered in photonic crystal fibers for an undepleted pump. The mode distributions are wavelength dependent, thus field overlap integrals cannot be simplified, and an extended gain region is observed.