gebhart/patrepeval huggingface dataset:
Sistema de caracterización circuital en gran señal para cargas inductivas. Aplicación en inducción doméstica (2009)

EN ESTE DOCUMENTO SE DESCRIBE EL PROCESO DE DISENO Y CONSTRUCCION DE UN BANCO DE TRABAJO PARA LA CARACTERIZACION EN GRAN SENAL DE CARGAS INDUCTIVAS CON APLICACION AL ANALISIS DE SISTEMAS INDUCTORES EMPLEADOS EN LA APLICACION DE CALENTAMIENTO POR INDUCCION DOMESTICO. LA CARACTERIZACION SE REALIZA BAJO CONDICIONES DE TEMPERATURA Y CORRIENTE CONTROLADAS. LOS RANGOS POSIBLES DE POTENCIA Y FRECUENCIA SE INCREMENTAN CONSIDERABLEMENTE RESPECTO A LOS VALORES HABITUALES ENCONTRADOS EN LOS SISTEMAS DE MEDIDA COMERCIALES. DE ESTA FORMA SE POSIBILITA LA CARACTERIZACION PRECISA DE CARGAS EN CONDICIONES NOMINALES Y EXTREMAS DE FUNCIONAMIENTO, ASI COMO LA EXPLORACION DE NUEVAS CONDICIONES DE EXCITACION Y CONTROL CON CARGAS VARIABLES. EL BANCO DE TRABAJO CONSTA DE UN SISTEMA DE EXCITACION BASADO EN UN INVERSOR VERSATIL DE ALTAS PRESTACIONES (TENSION DE ALIMENTACION MAXIMA DE 300 V, CORRIENTE MAXIMA DE SALIDA DE 40 A EFICACES, POTENCIA MAXIMA DE 7 KW Y FRECUENCIA DE CONMUTACION ENTRE 1 KHZ Y 1,5 MHZ), CAPAZ DE OPERAR EN BANDA ANCHA BAJO DIFERENTES SITUACIONES DE CONTROL. DE ESTE MODO, EL SISTEMA DE EXCITACION DISENADO TAMBIEN PUEDE EMPLEARSE COMO INSTRUMENTO DE LABORATORIO UTIL PARA EL DISENO DE SISTEMAS DE CALENTAMIENTO POR INDUCCION DOMESTICO. POR EJEMPLO, PUEDE EMPLEARSE PARA COMPARAR LAS PRESTACIONES DE AQUELLAS ESTRATEGIAS DE CONTROL DE INVERSORES MENOS CONVENCIONALES. LA FRECUENCIA DE RESONANCIA DE LA CARGA BAJO CARACTERIZACION PUEDE AJUSTARSE GRACIAS AL EMPLEO DE DOS BANCOS DE CONDENSADORES AJUSTABLES. TODAS LAS POSIBILIDADES DE CONTROL DEL INVERSOR SE EXPLOTAN GRACIAS A LA ELABORACION DE UN GENERADOR DIGITAL VERSATIL DE SENALES DE DISPARO BASADO EN FPGA Y CONTROLABLE DESDE EL PC. ASIMISMO, EL BANCO DE TRABAJO CONSTA DE UN SISTEMA DE MEDIDA DISENADO A TAL EFECTO PARA LLEVAR A CABO LA CARACTERIZACION DE FORMA PRECISA. EN EL DOCUMENTO SE DETALLAN LOS PASOS DE QUE CONSTA LA MEDIDA Y SE JUSTIFICA LA SELECCION DE LOS SENSORES EMPLEADOS ASI COMO EL PROCEDIMIENTO DE CALIBRACION DE LOS MISMOS. POR ULTIMO, SE DESCRIBE LA APROXIMACION EMPLEADA PARA LA IDENTIFICACION DE LOS PARAMETROS EQUIVALENTES CARACTERISTICOS DE LA CARGA DE INDUCCION. FINALMENTE, CON LA INFORMACION DE CARACTERIZACION OBTENIDA SE PROPONE UNA APROXIMACION AL MODELADO CIRCUITAL LINEAL Y NO LINEAL DE LA CARGA DE INDUCCION DOMESTICA QUE REFLEJE EL COMPORTAMIENTO DINAMICO DE LA MISMA. LOS MODELOS PROPUESTOS SE VALIDAN PARA ALGUNOS DE LOS CASOS ANALIZADOS COMPRENDIENDO DIVERSAS ESTRUCTURAS Y GEOMETRIAS DE SISTEMAS INDUCTORES.
Radar Micro-Doppler Signal Encoding in Siegel Unit Poly-Disk for Machine Learning in Fisher Metric Space (2018)

For classification of Radar micro-Doppler signature by Machine Learning techniques, first step consists in coding the data in well adapted metric space. We propose a new approach to code the time series of I&Q raw data by a Matrix Autoregressive model from a sequence of covariance Toeplitz Hermitian Positive matrices, estimated on a sliding window. We use matrix extension of Trench-Verblunsky theorem proving that a Toeplitz-Block-Toeplitz matrix is parameterized by Matrix Verblunsky coefficients lying in Siegel Unit Poly-Disk, to introduce a Fisher metric space from Information Geometry for this canonical parameterization. We present the coding procedure of micro-Doppler signal in Siegel space and conclude with examples of Machine Learning based on Mean-Shift algorithm in this metric space.
Implementing Algorithms in the Cloud (2018)

Sometimes the amount of computation required to carry out a task can be enormous. This typically happens when there is a large dataset that has a size greater than the typical RAM size of a machine. It can also typically happen when the required processing on the data is huge.
Beyond 3G: vision, requirements, and enabling technologies (2003)

This article introduces the vision and requirements for future development of mobile communications systems, and discusses several key enabling technologies such as modulation and multiple access schemes, multiple antenna techniques, and an IP-based network, considered important to realize this vision in real-world systems.
Management of different energy storage devices using a losses minimization algorithm (2011)

The paper presents a methodology for controlling different energy storage devices based on their efficiency curves and derived from their power losses functions. This control strategy was tested through simulations on a DC distribution system made up of two different energy storage devices (i.e., lead-acid battery and supercapacitors), and an active DC load. The effectiveness of the proposed algorithm was evaluated with different types of load cycles describing three benchmark driving cycles and was compared to different empiric strategies that set a constant share of the requested power between the storage devices.
Alternative splicing during chondrogenesis: Modulation of fibronectin exon EIIIA splicing by SR proteins (2002)

The alternative exon EIIIA of the fibronectin gene is included in mRNAs produced in undifferentiated mesenchymal cells but excluded from differentiated chondrocytes. As members of the SR protein family of splicing factors have been demonstrated to be involved in the alternative splicing of other mRNAs, the role of SR proteins in chondrogenesis-associated EIIIA splicing was investigated. SR proteins interacted with chick exon EIIIA sequences that are required for exon inclusion in a gel mobility shift assay. Addition of SR proteins to in vitro splicing reactions increased the rate and extent of exon EIIIA inclusion. Co-transfection studies employing cDNAs encoding individual SR proteins revealed that SRp20 decreased mRNA accumulation in HeLa cells, which make A+ mRNA, apparently by interfering with pre-mRNA splicing. Co-transfection studies also demonstrated that SRp40 increased exon EIIIA inclusion in chondrocytes, but not in HeLa cells, suggesting the importance of cellular context for SR protein activity. Immunoblot analysis did not reveal a relative depletion of SRp40 in chondrocytic cells. Possible mechanisms for regulation of EIIIA splicing in particular, and chondrogenesis associated splicing in general, are discussed.
Splicing: still so much to learn (2015)

This issue marks the 20th year since the launching of RNA in March of 1995. It is a time to celebrate, as well as to consider the substantial accomplishments achieved in these two decades, both in the RNA field as a whole, and in the specific areas in which each of us works—in my case, human pre-mRNA splicing mechanisms and regulation, and its relevance to human disease. Moreover, this is a time to reflect about where our field is headed, and what are the unique opportunities and obstacles in our path. With no intention of being exhaustive in listing major achievements, I would first single out certain technical advances from which virtually everyone in the RNA field and beyond is substantially benefitting, and which satisfyingly emerged from careful characterization of novel natural phenomena. One of these is RNA interference, which has led to various powerful, widely used tools for targeted gene knockdown, as well as to major efforts in therapeutics development. A more recent example consists of the prokaryotic CRISPR/Cas systems, which are rapidly being adapted as powerful tools for targeted genome editing. Other important technical developments include methods for massively parallel RNA-sequence analysis, and related techniques for systematically footprinting binding sites of proteins or RNP complexes on RNA (e.g., ribosome profiling, CLIP). These methods take advantage of the availability of complete or nearly complete genome sequences, and require appropriate use of computational and statistical tools.
Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering (1998)

Novel lactide-based poly(ethylene glycol) (PEG) polymer networks (GL9-PEGs) were prepared by UV copolymerization of a glycerol-lactide triacrylate (GL9-Ac) with PEG monoacrylate (PEG-Ac) to use as scaffolds in tissue engineering, and the surface properties and biocompatibility of these networks were investigated as a function of PEG molecular weight and content. Analysis by ATR-FTIR and ESCA revealed that PEG was incorporated well within the GL9-PEG polymer networks and was enriched at the surfaces. From the results of SEM, AFM, and contact angle analyses, GL9-PEG networks showed relatively rough and irregular surfaces compared to GL9 network, but the mobile PEG chains coupled at their termini were readily exposed toward the aqueous environment when contacting water such that the surfaces became smoother and more hydrophilic. This reorientation and increase in hydrophilicity were more extensive with increasing PEG molecular weight and content. As compared to GL9 network lacking PEG, protein adsorption as well as platelet and S. epidermidis adhesion to GL9-PEG networks were significantly reduced as the molecular weight and content of PEG was increased, indicating that GL9-PEG networks are more biocompatible than the GL9 network due to PEG's passivity. Based on the physical and biological characterization reported, the GL9-PEG materials would appear to be interesting candidates as matrices for tissue engineering.
Analysis of the Ros repressor of Agrobacterium virC and virD operons: molecular intercommunication between plasmid and chromosomal genes (1993)

The virulence genes of the Agrobacterium tumefaciens Ti plasmid are regulated both positively and negatively. The products of the genes of the virC and virD operons play an important role in host specificity and T-DNA processing. These operons are transcribed in opposite directions and therefore bear diametrically oriented promoters. These promoters are positively regulated by the VirG protein, which is believed to be activated through phosphorylation by a histidine kinase encoded by the virA gene. The virC and virD operons are also regulated by a 15.5-kDa repressor protein encoded by the ros chromosomal gene. A mutation in ros causes the constitutive expression of virC and virD in the complete absence of the VirG protein. It appears, therefore, that the Ros repressor interacts with the regulatory region of these operons. The Ros repressor is shown here to bind to an upstream sequence (Ros box) comprising 40 bp bearing a 9-bp inverted repeat, TATATTTCA/TGTAATATA, in the promoter region of these operons. The affinity for this sequence is specific and tenacious, since the addition of at least a 20,000-fold excess of competitor DNA failed to remove the Ros protein coding sequence from the Ros box. DNase I footprint analysis showed that the Ros box overlaps the binding site of VirG (Vir box). This result suggests that virC and virD transcription is modulated by Ros and VirG proteins.
Towards a mission planning toolbox for the Airborne Network: Optimizing ground coverage under connectivity constraints (2008)

The airborne network (AN) is a constellation of networked aircrafts flying in periodic orbits. AN is an enabling technology for network centric warfare for the military, autonomous air traffic control for commercial aviation and for providing Internet access over a broad urban area. AN is a highly dynamic environment and presents challenges that have not been addressed in traditional wire-line or wireless MANET research. Wireless links in AN are quasi-persistent and break due to platform banking and antenna shadowing. In this paper, the objective is to deploy airborne nodes so that they provide ground nodes with high data upload capacity while making sure that a minimal topology within the backbone airborne network is always maintained. For the sake of simplicity of presentation we make a few assumptions on the trajectories of the airborne nodes. We verify our assumptions against a well studied airborne network deployment scenario. Using tools from convex optimization we determine optimal locations of airborne nodes for three different scenarios. We present our results graphically and illustrate them using examples.
A 65 nm CMOS SOI 4-bit Digitally Controlled Variable Gain Amplifier for Ka-Band Beamforming (2021)

This paper presents the design and implementation of Ka-band variable gain amplifier (VGA) digitally controlled in 65 nm CMOS SOI with low impedance and low phase variation. In this VGA topology, the control transistor is placed at the source of the differential pair of RF transistors. That allows to optimize the control transistor without impacting the RF performance. The gain control is done by switching positive and negative cells with different gm. Low impedance and low phase variation are achieved by keeping the same number of transistors ON and OFF and by gate-drain capacitor neutralization. The measured VGA achieves a 21.1 dB linear-in-magnitude tuning range with 8.8 dB gain peak. The RMS phase error is less than 2.2° over the 3-dB bandwidth of 25~33 GHz. The VGA consumes 21 mW with 1.4 V supply voltage and the input 1-dB compression point is -3.2 dBm. The chip size is 190 µm × 225 µm.
Latticework (Vortex) Cooling Effectiveness: Rotating Channel Experiments (2004)

The heat transfer and pressure drop characteristics of latticework coolant blade passages have been investigated experimentally under conditions of rotation. Stationary studies with the latticework configuration have shown potential advantages including spatially-uniform streamwise distributions of the heat transfer coefficient, greater blade strength, and enhancement levels comparable to conventional rib turbulators. In the present study, a latticework coolant passage, with orthogonal-ribs, is studied in a rotating heat transfer test-rig for a range of Reynolds numbers (Res), Rotation numbers (Ros), and density ratios. Measurements indicate that for Res⩾20,000, the latticework coolant passage provides very uniform streamwise distributions of the Nusselt number (Nus) with enhancement levels (relative to smooth-channel values) in the range of 2.0–2.5. No significant dependence of Nus on Ros and density ratio is observed except at lower Res values (⩽10,000). Nusselt numbers are highest immediately downstream of a turn indicating that bend-effects play a major role in enhancing heat transfer. Friction factors are relatively insensitive to Ros, and thermal performance factors at higher Res values appear to be comparable to those obtained with conventional rib-turbulators. The present study indicates that latticework cooling geometry can provide comparable heat transfer enhancements and thermal performance factors as conventional rib-turbulators, with potential benefits of streamwise uniformity in the heat transfer coefficients and added blade strength.
Controlled release of propham from plastic granules (1978)

Urea–formaldehyde granules containing propham, a volatile herbicide, have been tested in the laboratory as well as in the field as a suitable controlled release system. The advantages of such a system compared to the present commonly used formulas are being demonstrated.
Verminderte Glyoxalase-1 Aktivität bei Patienten mit schmerzhafter diabetischer Neuropathie (2007)

Ziele: Die Akkumulation von Advanced Glycation Endproducts (AGEs) im Gewebe von Patienten mit Diabetes mellitus (DM) gilt als eine Ursache für die Entstehung diabetischer Spätschäden. Da ein wesentlicher Teil von AGEs intrazellulär aus Methylglyoxal entsteht, stellt das intrazelluläre Glyoxalasesystem, das Methylglyoxal und andere a-Oxoaldehyde detoxifizieren kann, einen wichtigen Abwehrmechanismus dar. In Vorarbeiten konnten wir nachweisen, dass Hypergykämie und AGE-Bindung an den Oberlächenrezeptor RAGE GO-1-Expression und Transkription mindert. Diese Daten legen nahe, dass das eine verminderte GO-1 Expression und die damitverbundene Akkumulation von AGEs zur Entstehung diabetischer Spätkomplikationen, insbesondere zur diabetischen Neuropathie, bei Patienten mit Diabetes mellitus beitragen könnte.
Herpes Simplex Virus Type-1 Attachment Inhibition by Functionalized Graphene Oxide (2013)

Graphene oxide and its derivatives have lately been the subject of increased attention in the field of bioscience and biotechnology. In this article, we report on the use of graphene oxide (GO) derivatives to inhibit herpes simplex virus type-1 (HSV-1) infections, mimicking the cell surface receptor heparan sulfate, and the GO derivatives compete with the latter in binding HSV-1. The inhibition does not affect cell-to-cell spreading. Media content has a significant effect on the inhibition properties of the nanomaterials. These have no cytotoxic effect, suggesting that this is a promising approach for the development of antiviral surfaces and for diagnostic purposes.
Vaginal Cuff Dehiscence: Risk Factors and Associated Morbidities (2015)

The rate of cuff dehiscence in our cohort correlates with the current literature. This study suggests that the risk of dehiscence is influenced mainly by the scope and complexity of the surgical procedure. It seems that different colpotomy techniques do not influence the rate of cuff dehiscence; however, continuous suturing of the cuff may be superior to interrupted suturing.
Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies (2008)

Bladder cancer is the fifth most common malignancy in the UK. Clinically, the most important process in determining prognosis is the development of invasion, initially of the lamina propria and then beyond as these transitional cell carcinomas (TCCs) progress from stage pT1 to stages T2+. Cadherins and catenins are the main mediators of cell-cell interactions in epithelial tissues, and loss of membranous E-cadherin immunoreactivity is strongly correlated with high grade, advanced stage and poor prognosis in bladder cancer and other malignancies. However, the role of P-cadherin is yet to be fully elucidated in bladder TCC. The objectives of this study were to establish how the expression of cadherins and catenins determines clinical and in vitro behaviour in bladder TCC. Utilizing immunohistochemistry, immunofluorescence and western blotting, we demonstrated a significant reduction in the expression of E-cadherin and beta-catenin as grade and stage of bladder TCC progress, accompanied by a significant increase in P-cadherin expression (all p < 0.05, Pearson's chi2 test). Increased P-cadherin expression was also associated with a significantly worse bladder cancer-specific survival (log rank p = 0.008), with Cox regression showing P-cadherin to be an independent prognostic factor. Utilizing a variety of tissue culture models in a range of functional studies, we demonstrated that P-cadherin mediates defective cell-cell adhesion and enhances anchorage-independent growth. The results provide evidence that increased P-cadherin expression promotes a more malignant and invasive phenotype of bladder cancer, and appears to have a novel role late in the disease.
Invited talk: Early estimation of on-chip clock jitter accumulation &#x2014; A brief tutorial (2014)

Power supply induced clock jitter accumulation is a function of several variables including the power supply rejection characteristics of circuits in the signal path, signal path electrical length, signaling frequency, and voltage supply noise magnitude and frequency. Brute force, closed-loop, transistor-level modeling and simulation of clock timing in the presence of an extracted power delivery network are resource intensive. In addition, circuit and power delivery network designs are often not complete enough to run such analyses at an early stage in the design cycle, and the longer a design waits to identify circuit and supply sensitivities, the more costly the corrections become. Understanding the relationships between the signal path electrical length, signaling frequency and supply noise frequency enables early jitter estimation and can be used to drive both circuit and power delivery network design optimization. This paper summarizes the general inter-dependencies between these variables and then demonstrates how these principles might be used to make design optimizations in the context of the Low Power Double Data Rate Four (LPDDR4) interface.
Electron and hole transfer in anion-bound chemically amplified resists used in extreme ultraviolet lithography (2014)

The uniformity of acid generator distribution and the length of acid diffusion are serious problems in the development of resist materials used for the 16nm node and below. Anion-bound polymers in which the anion part of onium salts is polymerized have attracted much attention for solving these problems. In this study, the reaction mechanism of an anion-bound polymer in cyclohexanone was clarified using pulse radiolysis. The design of an efficient electron and hole transfer system is essential to the enhancement of resist performance.
Relationship between sensitizer concentration and resist performance of chemically amplified extreme ultraviolet resists in sub-10 nm half-pitch resolution region (2016)

Abstract The development of lithography processes with sub-10 nm resolution is challenging. Stochastic phenomena such as line width roughness (LWR) are significant problems. In this study, the feasibility of sub-10 nm fabrication using chemically amplified extreme ultraviolet resists with photodecomposable quenchers was investigated from the viewpoint of the suppression of LWR. The relationship between sensitizer concentration (the sum of acid generator and photodecomposable quencher concentrations) and resist performance was clarified, using the simulation based on the sensitization and reaction mechanisms of chemically amplified resists. For the total sensitizer concentration of 0.5 nm −3 and the effective reaction radius for the deprotection of 0.1 nm, the reachable half-pitch while maintaining 10% critical dimension (CD) LWR was 11 nm. The reachable half-pitch was 7 nm for 20% CD LWR. The increase in the effective reaction radius is required to realize the sub-10 nm fabrication with 10% CD LWR.
The unfolded protein response regulates MHC class I‐peptide presentation (2008)

Cell stress elicits the unfolded protein response (UPR). UPR regulates the two processes that control MHC I‐peptide (MHC I‐p) presentation: protein translation and degradation. We therefore asked whether and how the UPR might modify MHC I‐p presentation. We evaluated the impact of the UPR on global MHC I expression and on presentation of the SIINFEKL peptide. EL4 cells stably transfected with bicistronic vectors coding HEL‐SIINFEKL protein variants were stressed with pharmacological agents or exposed to physiologically relevant stress, such as glucose deprivation, for various time durations. UPR intensity was monitored by western blot and/or qRT‐PCR analysis of BiP, XBP‐1 and phosphorylation of eIF2alpha. Expression of Kb and of Kb‐SIINFEKL was assessed by flow cytometry with or without prior acid peptide elution. UPR decreased surface expression of MHC, but did not affect its mRNA. Consequently, presentation of SIINFEKL by H2‐Kb molecules was decreased in chemically or physiologically stressed cells. During the UPR, cells preferentially presented MHC I‐p derived from the ER as opposed to the cytosol. Also, generation of de novo Kb‐SIINFEKL complexes was less affected for ER‐ vs. cytosol‐derived SIINFEKL. Our results show that the UPR affects MHC I‐p presentation and that it differentially regulates expression of ER‐ vs. cytosol‐derived peptides. Supported by the NCIC.