gebhart/patrepeval huggingface dataset:
Parallel Stitching of Two-Dimensional Materials (2015)

Diverse parallel stitched two-dimensional heterostructures are synthesized, including metal-semiconductor (graphene-MoS2), semiconductor-semiconductor (WS2-MoS2), and insulator-semiconductor (hBN-MoS2), directly through selective sowing of aromatic molecules as the seeds in chemical vapor deposition (CVD) method. Our methodology enables the large-scale fabrication of lateral heterostructures with arbitrary patterns, and clean and precisely aligned interfaces, which offers tremendous potential for its application in integrated circuits.
The sensitising action of a TIM16 inhibitor towards chemotherapeutic agents in human breast cancer cells depends on TIM16 expression (2015)

We found that Magmas protein (Tim16) in the MCF7 cell line is highly expressed as compared to MDA-MB231 cells and MCF12A. Our data show that treatment with compound 5 did not influences cell viability in the 3 cell lines , while Doxorubicin decrease this parameter by 20-30%. Only in MCF7 co-treatment with compound 5 enhance the antiproliferative effects of Doxorubicin.
Self-calibrating measurement of polarization-dependent frequency shifts from Rb−3He collisions (1994)

We have studied the frequency shift in the Rb electron-paramagnetic-resonance (EPR) line due to the presence of nuclear polarized $^{3}\mathrm{He}$. By measuring the resonant frequency in a cylindrical cell oriented both parallel and perpendicular to an applied magnetic field, we determined the classical EPR shift due to long-range macroscopic fields. We thus calibrated the larger, geometry-independent shift, due to the Fermi-contact interaction between the Rb electron and the $^{3}\mathrm{He}$ nucleus, to 2.5%. The EPR frequency shift can be used to determine the $^{3}\mathrm{He}$ nuclear polarization.
Synergistic Growth-Inhibitory Effects of Two Tyrosine Kinase Inhibitors, Dasatinib and PKC412, on Neoplastic Mast Cells Expressing the D816V-Mutated Oncogenic Variant of KIT. (2006)

Abstract In a majority of all patients with systemic mastocytosis (SM) including aggressive SM and mast cell leukemia (MCL), neoplastic cells display the D816V-mutated variant of KIT. The respective oncoprotein, KIT-D816V, exhibits constitutive tyrosine kinase (TK) activity and has been implicated in malignant cell growth. Therefore, several attempts have been made to identify KIT-D816V-targeting drugs. We found that the TK-inhibitor dasatinib (BMS-354825) inhibits TK activity of wild type (wt) KIT and KIT-D816V in Ba/F3 cells with doxycycline-inducible KIT-expression. In addition, dasatinib was found to inhibit KIT D816V-induced cluster formation and viability in Ba/F3 cells as well as growth of HMC-1.1 cells (KIT-D816V-negative) and HMC-1.2 cells (KIT-D816V-positive). The effects of dasatinib on growth of HMC-1 cells were dose-dependent, with 100–1,000-fold higher IC50-values in cells harbouring KIT-D816V compared to cells lacking KIT-D816V. Furthermore, dasatinib was found to inhibit the growth of primary neoplastic mast cells in SM in all patients examined. The inhibitory effects of dasatinib in HMC-1 cells were found to be associated with apoptosis and a decrease in expression of CD2 and CD63 as determined by flow cytometry. In addition, dasatinib was found to cooperate with the tyrosine kinase inhibitors PKC412 (midostaurin), AMN107 (nilotinib), and STI571 (imatinib), as well as with 2CdA (cladribine) in producing growth-inhibition in neoplastic mast cells. In HMC-1.1 cells, all drug-interactions applied were found to be synergistic. By contrast, in HMC-1.2 cells, only the combinations “dasatinib+PKC412” and “dasatinib+2CdA” were found to produce synergistic effects. These drug-combinations may thus represent an interesting pharmacologic approach for the treatment of patients with aggressive systemic mastocytosis or mast cell leukemia.
Phannacokinetic‐pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats (1990)

1. The purpose of this investigation was to examine in vivo drug-concentration anticonvulsant effect relationships of oxazepam in individual rats following administration of a single dose. 2. Whole blood concentration vs time profiles of oxazepam were determined following administration of doses of 4, 8 and 12 mg kg-1. The pharmacokinetics could be described by an open 2-compartment pharmacokinetic model. Following 12 mg kg-1 the values (mean +/- s.e., n = 11) of clearance and volume of distribution were 28 +/- 2 ml min-1 kg-1 and 2.6 +/- 0.31 kg-1, respectively, and were not significantly different from the values obtained at the other doses. 3. The anticonvulsant effect was quantitated by a new technique which allows repetitive determination of the convulsive threshold by direct cortical stimulation within one rat. Significant dose-dependent elevations of the seizure threshold were observed. 4. By pharmacokinetic-pharmacodynamic modelling, a log-linear relationship was found between concentration and anticonvulsant effect. Following 12 mg kg-1 the values (mean +/- s.e., n = 11) of the pharmacodynamic parameters slope and minimal effective concentration (Cmin) were 243 +/- 27 microA and 0.11 +/- 0.02 mg l-1, respectively and not significantly different from the values obtained at the other doses. 5. In a repeatability study the pharmacodynamic parameters were determined twice on two different occasions with an interval of two weeks in the same group of 11 rats. The inter-animal variability in the pharmacodynamic parameter slope was 46%, whereas the intra-animal variability was 24 +/- 18%. The value of the minimal effective concentration was in each animal and on each occasion close to zero within the relatively narrow range of 0.01-0.30mgI. 6. The results of this study showed that it is possible to determine in vivo concentration-anticonvulsant effect relationships of oxazepam under non-steady-state conditions in individual rats. The anti-convulsant effect of oxazepam appeared to be a rapidly reversible direct effect and acute tolerance did not develop within the time frame of the experiments.
Supplementary Table 4 from Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy (2023)

&lt;p&gt;PDF file - 47KB, Expression analysis in ovarian cancer cell lines.&lt;/p&gt;
Practical Aspects of Cognitive Radar (2020)

In this paper we examine some of the practical aspects of implementing cognitive radar (CR) techniques onto software defined radar (SDRadar) platforms. These aspects include: 1) the response time (RT) of algorithms and components to determine latency bottlenecks, 2) autonomous regulation of the perception-action cycle (PAC) to determine “how fast the CR can interact with the environment” as well as “how fast the CR should interact with the environment,” and 3) regulation of the cognition level to understand how to select a particular CR technique appropriately for a given dynamically-changing environment. To provide concrete examples of these three implementation aspects for CR, we will focus on the specific application of target tracking in a congested spectral environment.
Chiral recognition of Nα‐protected amino acids and derivatives in non‐covalently molecularly imprinted polymers (1994)

Highly crosslinked synthetic polymers, selective for various N alpha-protected amino acids and derivatives, were prepared by non-covalent molecular imprinting. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the print molecules, which were subsequently extracted from the polymers. The recognition of the polymers for the print molecules and molecules of similar structures was investigated by using the polymers as stationary phases in HPLC. The functional groups of the print molecules interact via hydrogen bonds with the positioned carboxyls of the polymer. It was shown that the N alpha-protecting group, the C alpha-protecting group and the amino acid side chain are also recognized by the binding sites in the polymer.
Pure Phase Disordered LiMn1.45Cr0.1Ni0.45O4 by Post-Annealing Treatment (2013)

A new post-annealing treatment at ca. 600 °C was used to modify the oxygen deficiency during the synthesis of the spinel LiMn 1.45 Cr 0.1 Ni 0.45 O 4 cathode for Li-ion batteries. It is an effective way to eliminate the impurity phase without changing the crystal chemistry. Small amount of substituting Cr leads to better rate performance and cyclability at room temperature, compared to commercial LiMn 1.5 Ni 0.5 O 4 . LiMn 1.45 Cr 0.1 Ni 0.45 O 4 delivered a reversible capacity of 104 mAh g -1 at 1C rate. After 125 cycles, about 99% of reversible capacity was retained for the LiMn 1.45 Cr 0.1 Ni 0.45 O 4 in contrast with 6% capacity loss for the commercial LiMn 1.5 Ni 0.5 O 4 . Electrochemical impedance spectroscopy measurements revealed that the LiMn 1.45 Cr 0.1 Ni 0.45 O 4 had a smaller surface resistance, which may be due to the segregation of Ni from the surface to the bulk.
Studies Using Electron Microscopy and Fluorescence Contents Mixing (1989)

Direct observations of membrane structural changes accompanying fusion events are invaluable to the understanding of membrane fusion mechanisms. In the ideal sense, sequences of morphological changes might be correlated with complementary data to assign kinetic and structure-function relationships during the fusion event. We have initiated this study by preserving the ultrastructural changes in the human erythrocyte membrane during electrofusion by rapid freeze quenching, followed by observation using freeze-fracture electron microscopy (EM). To provide an alternative means of monitoring the same events in a population of cells. we have used fluorescence contents­ mixing fusion assays. In this charter, we discuss how these techniques may be used to infer information regarding the mechanism(s) of electrofusion.
Ethics in security vulnerability research (2010)

Debate has arisen in the scholarly community, as well as among policymakers and business entities, regarding the role of vulnerability researchers and security practitioners as sentinels of information security adequacy. The exact definition of vulnerability research and who counts as a "vulnerability researcher" is a subject of debate in the academic and business communities. For purposes of this article, we presume that vulnerability researchers are driven by a desire to prevent information security harms and engage in responsible disclosure upon discovery of a security vulnerability. Yet provided that these researchers and practitioners do not themselves engage in conduct that causes harm, their conduct doesn't necessarily run afoul of ethical and legal considerations. We advocate crafting a code of conduct for vulnerability researchers and practitioners, including the implementation of procedural safeguards to ensure minimization of harm.
B4GALT6 regulates astrocyte activation during CNS inflammation (INM8P.360) (2015)

Abstract Astrocytes play complex roles in neuroinflammation. Thus, it is important to characterize the mechanisms regulating astrocyte function, as well as potential targets for the therapeutic modulation of astrocyte activity. Here we report that during the chronic-progressive phase of EAE, astrocytes promote disease pathogenesis by a lipid-dependent signaling pathway. In line with previous studies, depletion of reactive astrocytes during the acute phase of chronic-progressive EAE exacerbated disease. However, depletion of astrocytes in the chronic phase ameliorated the disease. Hence, to understand this dichotomy we compared gene expression profiles of astrocytes from mice in acute and chronic stages of EAE. One gene associated with the chronic stage was B4GALT6, which codes for the β-1,4-galactosyltransferase 6 that catalyzes the synthesis of lactosylceramide (LacCer). We observed that LacCer levels are upregulated in the CNS during chronic EAE, and that LacCer synthesized by the astrocytes acts in an autocrine manner to trigger transcriptional programs that promote the recruitment and activation of infiltrating monocytes and microglia, and neurodegeneration. We also detected increased B4GALT6 expression and LacCer levels in MS lesions. Finally, the inhibition of LacCer synthesis suppressed CNS innate immunity and neurodegeneration, and interfered with the activation of human astrocytes. Thus, B4GALT6 is a potential therapeutic target for MS and neuroinflammatory disorders.
Precise lightwave control for high-speed wired and wireless transmission (2012)

We present recent progress of high-speed electro-optic device technologies for radio-on-fiber (RoF) systems. Digital and analog signals can be transmitted over a fiber, in RoF systems. Advanced modulation technique is also very important both in wired and wireless systems. Multi-level quadrature amplitude modulation signal can be synthesized by using parallel Mach-Zehnder modulators.
Vapor-liquid equilibria of tetrahydrofuran systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibria of tetrahydrofuran systemsHuey S. Wu and Stanley I. SandlerCite this: J. Chem. Eng. Data 1988, 33, 2, 157–162Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/je00052a030https://doi.org/10.1021/je00052a030research-articleACS PublicationsRequest reuse permissionsArticle Views694Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Zinc oxide nanowire networks for macroelectronic devices (2009)

Highly transparent zinc oxide (ZnO) nanowire networks have been used as the active material in thin film transistors (TFTs) and complementary inverter devices. A systematic study on a range of networks of variable density and TFT channel length was performed. ZnO nanowire networks provide a less lithographically intense alternative to individual nanowire devices, are always semiconducting, and yield significantly higher mobilites than those achieved from currently used amorphous Si and organic TFTs. These results suggest that ZnO nanowire networks could be ideal for inexpensive large area electronics.
Second-row occupant responses with and without intrusion in rear sled and crash tests (2020)

The crash tests show that intrusion increases occupant responses in the right second-row seat and pushes the occupant forward in rear impacts. The sled tests without intrusion had relatively low biomechanical responses. Intrusion was influenced by the crash energy and cargo.
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance (2018)

SUMMARY The observation that humans can produce broadly neutralizing antibodies (bnAbs) against HIV-1 has generated enthusiasm about the potential for a bnAb vaccine against HIV-1. Conventional immunization strategies will likely be insufficient for the development of a bnAb HIV vaccine and vaccines to other difficult pathogens, due to the significant immunological hurdles posed, including B cell immunodominance and germinal center (GC) quantity and quality. Using longitudinal lymph node fine needle aspirates, we found that two independent methods of slow delivery immunization of rhesus macaques (RM) resulted in larger GCs, more robust and sustained GC Tfh cell responses, and GC B cells with improved Env-binding, which correlated with the development of ~20 to 30-fold higher titers of tier 2 HIV-1 nAbs. Using a new RM genomic immunoglobulin loci reference sequence, we identified differential IgV gene usage between slow delivery immunized and conventional bolus immunized animals. The most immunodominant IgV gene used by conventionally immunized animals was associated with many GC B cell lineages. Ab mapping of those GC B cell specificities demonstrated targeting of an immunodominant non-neutralizing trimer base epitope, while that response was muted in slow delivery immunized animals. Thus, alternative immunization strategies appear to enhance nAb development by altering GCs and modulating immunodominance of non-neutralizing epitopes.
Synthesis and Structures of Vanadium–Cerium Trinuclear Complexes with Schiff-Base Ligands (2006)

Abstract A vanadium(V)–cerium(IV) trinuclear complex, [{VVO2(L1)}2CeIV] (1) (H3L1: N,N′-bis-3-ethoxysalicylidene-2-hydroxy-1,3-propanediamine), was prepared by the reaction of [VIVO(acac)2] and [CeIII(acac)3]·3H2O with H3L1 in CH3CN, followed by oxidation of the product in air. The structure of complex 1 was determined by X-ray crystal structure analysis. The complex has a VV–CeIV–VV trinuclear structure with two dioxovanadium(V) moieties on each side of the cerium(IV) moiety. Complex 1 has two L1 ligands to form a trinuclear structure. The basal oxo atoms of the dioxovanadium(V) moieties are coordinated to the cerium atom with Ce–O distances of 2.322(3) and 2.343(3) Å. The apical two non-coordinating oxo atoms are oriented to the same direction to form an endo structure. IR data of complex 1 show V=O stretching bands at 975 cm−1 for the apical non-coordinated oxo atoms and 802 cm−1 for the basal coordinated oxo atoms. The cyclic voltammogram of complex 1 in CH3CN shows a quasi-reversible two-electron redox couple with E1/2 = −0.60 V vs Fc/Fc+.
Determining the power distribution between two coupled coils based on Poynting vector analysis (2017)

Inductive power transfer (IPT) systems have been developed as an alternative to the traditional direct electrical contact power supplies to drive one or more moveable and electrically isolated loads. However, to date little is known about the power distribution in an IPT system in relation to the power transfer mechanism. This paper presents the power distribution between two magnetically coupled coils in an IPT system based on the Poynting vector analysis. Both magnetic fields and electric fields are analyzed to determine the Poynting vector and to show the load effect on its distribution. It has found that the loading position and the load value of the secondary coil have little effect on the magnetic field distribution, but they change the electric field distribution significantly, consequently the Poynting vector distribution between the two coupled coils varies. This result is useful for understanding the power flow distribution in an IPT system and guiding practical Electromagnetic Compatibility (EMC) design of a wireless power transfer system.
Genetic algorithm for optimization of L-shaped PIFA antennas (2011)

Two new designs of the L-shaped Planar Inverted–F Antenna (PIFA) antennas with single and dual polarization operating at the frequency band for IEEE 802.11b/g standard with satisfactory radiation characteristics are presented. We further propose a genetic algorithm (GA) embedded in CST Microwave Studio for optimizing these antenna parameters. The agreement of simulation and measurement results shows the performance of our joint model. Also, they show that our dual-polarization antenna is suitable for indoor Multiple Input Multiple Output (MIMO) wireless environment applications.
Supplementary Data from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma (2023)

Supplementary Data from Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma
Is Accurate Synoptic Altimetry Achievable by Means of Interferometric GNSS-R? (2019)

This paper evaluates the capability of interferometric global navigation satellite system reflectometry (GNSS-R) to perform sea surface altimetry in a synoptic scenario. Such purpose, which requires the combination of the results from different GNSS signals, constitutes a unique characteristic of this approach. Interferometric GNSS-R group delay altimetry has been proven to be more precise than conventional GNSS-R. However, the self-consistency and accuracy of their synoptic solutions (simultaneous multi-static results) have never been proved before. In our work, we analyze a dataset of GNSS signals reflected off the Baltic Sea acquired during an airborne campaign using a receiver that was developed for such a purpose. Among other features, it enables beamformer capability in post-processing to get multiple and simultaneous GNSS signals under the interferometric approach’s restrictions. In particular, the signals from two GPS and two Galileo satellites, at two frequency bands (L1 and L5), covering an elevation range between 28° and 83°, are processed to retrieve sea surface height estimations. The results obtained are self-consistent among the different GNSS signals and data tracks, with discrepancies between 0.01 and 0.26 m. Overall, they agree with ancillary information at 0.40 m level, following a characteristic height gradient present at the experimental site.
ZEA, a data management approach for SMR (2016)

Digital data is projected to double every two years creating the need for cost effective and performant storage media [4]. Hard disk drives (HDDs) are a cost effective storage media that sit between speedy yet costly flashbased storage, and cheap but slower media such as tape drives. However, virtually all HDDs today use a technology called perpendicular magnetic recording, and the density achieved with this technology is reaching scalability limits due to physical properties of the technology [17]. While new technologies such as shingled magnetic recording (SMR) that further increase areal density are slated to enter the market [6], existing systems software is not prepared to fully utilize these devices because of the unique I/O constraints that they introduce. SMR requires systems software to conform to the shingling constraint. The shingling constraint is an I/O ordering constraint imposed at the device level, and requires that writes be sequential and contiguous within a subset of the disk, called a zone. Thus, software that requires random block updates must use a scheme to serialize writes to the drive. This scheme can be handled internally in a drive or an alternative approach is to expose the zone abstraction and shingling constraint to the host operating system. Host level solutions are challenging because the shingling constraint is not compatible with software that assumes a random-write block device model, which has been in use for decades. The shingling constraint influences all layers of the I/O stack, and each layer must be made SMR compliant. In order to manage the shingling write constraint of SMR HDDs, we have designed a zone-based extent allocator that maps ZEA logical blocks (ZBA) to LBAs of the HDD. Figure 1a depicts how ZEA is mapped onto a SMR HDD comprised of multiple types of zones, which are described in Table 1. ZEA writes logical extents, comprised of data and metadata, sequentially onto the SMR zone maintaining the shingling constraint. 2 Related Work