gebhart/patrepeval huggingface dataset:
The yield of peripheral blood stem cells (PBSC) in hematological or solid tumour patients treated with high dose chemotherapy and hemopoietic growth factors (2008)

22220 Background: Factors potentially relevant in the yield of PBSC (CFU-GM and CD34+ cells) were evaluated in solid tumors (breast cancer 45, other than breast cancer 9), multiple myeloma (MM 75), clinically indolent or aggressive non-Hodgkin lymphoma (I-NHL 20, A- NHL 84) or classical Hodgkin lymphoma (HL, 38) patients. Methods: These factors were divided into host (age, disease histology and stage), therapeutic history before mobilization (mobilizing therapy during first or salvage treatment, number of cycles and of drugs used and exposure to alkylating agents or radiotherapy) and mobilizing program-related (type of mobilizing chemotherapy and type and dose of hemopoietic growth factor). Intermediate-dose chemotherapy consisted of 3–4g/m2 cyclophosphamide (CTX) or 800mg/m2 carboplatin (CBDCA) or 8mg/m2 mithoxantrone, 3g/m2 cytarabine and 8mg/m2 dexamethasone days 1–2 (miniMAD) or 100mg/m2 cisplatinum day 1, 4g/m2 cytarabine day 2, 40mg dexamethasone days 1–4 (DHAP) or 120mg/m2 epirubicin. The combination of 8 mg/m2 mithoxantrone, 4 g/m2 cytarabine and 8 mg/m2 dexamethasone days 1–3 (MAD) or 7 g/m2 CTX or ifosfamide 4g/m2 were defined as high- dose chemotherapy. Results: Linear regression analysis indicated that recovery of CFU-GM/Kg and CD34+cells/Kg was affected by disease type (decreasing from solid tumors to I-NHL) and amount of chemotherapy expressed as number of drugs or chemotherapy cycles given before mobilization. However, the CFU-GM/Kg cells yield, but not that of CD34+ cells/Kg was higher when G-CSF rather than GM-CSF was employed. The number of CD34+ cells/Kg recovered was significantly superior in pts in complete remission at the time of mobilization and in those not previously exposed to radiation therapy. The mobilizing scheme employed affected the CFU-GM/CD34+ cell ratio indicating that large numbers of more immature precursors were obtained when 7g/CTX or MAD were employed. Conclusions: The yield of PBSC was mainly related to patient history, previous exposure to chemotherapy, state of disease at mobilization and mobilization scheme. No significant financial relationships to disclose.
Confidence Calibration for Domain Generalization under Covariate Shift (2021)

Existing calibration algorithms address the problem of covariate shift via unsupervised domain adaptation. However, these methods suffer from the following limitations: 1) they require unlabeled data from the target domain, which may not be available at the stage of calibration in real-world applications and 2) their performance depends heavily on the disparity between the distributions of the source and target domains. To address these two limitations, we present novel calibration solutions via domain generalization. Our core idea is to leverage multiple calibration domains to reduce the effective distribution disparity between the target and calibration domains for improved calibration transfer without needing any data from the target domain. We provide theoretical justification and empirical experimental results to demonstrate the effectiveness of our proposed algorithms. Compared against state-of-the-art calibration methods designed for domain adaptation, we observe a decrease of 8.86 percentage points in expected calibration error or, equivalently, an increase of 35 percentage points in improvement ratio for multi-class classification on the Office-Home dataset.
Value of Anti-neutrophil Cytoplasmic Autoantibodies and Other Laboratory Parameters in Follow-up of Vasculitis (1990)

The presence of anti-neutrophil cytoplasmic autoantibodies (ANCA), detected by indirect immunofluorescence, is of high sensitivity and specificity in the diagnosis of Wegener's granulomatosis and related diseases, associated with vasculitis. Titres of immunofluorescence are thought to closely reflect disease activity. In a retrospective series of 266 sera of 23 patients with at least one positive test for ANCA, disease activity was correlated with ANCA, assayed by immunofluorescence and by enzyme-linked immunosorbent assay; with rheumatoid factor and with erythrocyte sedimentation rate. All tests were of limited value in predicting disease activity or relapse. A normal sedimentation rate and, to a lesser extent, a negative result of ANCA-immunofluorescence, were useful in excluding active disease.
Supplemental Table 6 from Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA (2023)

&lt;p&gt;Allelic fractions for all variants detected in tDNA and ctDNA* in patients for whom both plasma and tissue samples were obtained (n=50)&lt;/p&gt;
Involvement of the Src-cortactin pathway in migration induced by IGF-1 and EGF in human breast cancer cells (2012)

Cancer cells need to become motile in order to escape the primary tumor and move to distant areas to form metastasis. They move as single cells or as a group, following different stimuli, including growth factors. Among them, insulin-like growth factor‑1 (IGF-1) and epidermal growth factor (EGF) and their receptors have been implicated in the development and progression of human breast carcinoma. In this report, we provide evidence that the tyrosine kinase Src is responsible for migration promoted by both IGF-1 and EGF in MDA-MB-231 and MCF7 cells, although with a different effect. Moreover, both IGF-1 and EGF induce reorganization of actin cytoskeleton in lamellipodia and membrane ruffles in a time- and Src-dependent manner. Furthermore, we analyzed the tyrosine phosphorylation status of the actin-binding protein cortactin upon growth factor stimulation, showing that even the activation of cortactin is time- and Src-dependent. In addition, immunofluorescence analysis with anti-paxillin antibody reveals that, after treatment with growth factors, tyrosine phosphorylated cortactin is localized on the plasma membrane in correspondence of focal adhesions. Collectively, our findings suggest a crucial role for Src-mediated activation of cortactin in cell migration, reorganization of actin cytoskeleton and phosphotyrosine cortactin localization to the focal adhesions in human breast cancer cell lines upon both IGF-1 and EGF stimulation.
Water Fountain Speed and Height at Strokkur Geyser, Iceland, derived from Video Camera Data (2022)

&amp;lt;p&amp;gt;Strokkur geyser in Iceland is located in the Haukadalur valley, Iceland. It exhibits frequent, jetting eruptions of hot water and non-condensable gases such as CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;. In earlier studies we found that Strokkur geyser erupts at regular intervals and passes through typical phases in an eruptive cycle. This eruptive cycle consists of the eruption, conduit refilling with water, gas accumulation in a bubble trap and regular bubble collapses at depth in the conduit. In this presentation we focus on the blue bulge that forms at the beginning of an eruption and the water fountain itself.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;To study this, we use video camera data from 2017 and 2020 in comparison with a local broadband seismic network. We assess the bulge height, fountain height, the bulge rising speed, water fountain rising speed and the associated seismic amplitude. Particularly, ImageJ with the MtrackJ plugin was used to assess the bulge height and fountain height. We find that upto 0.5 m high water bulge forms within 0.7 s at an average speed of 0.6 m/s. Water is then expelled into the air at a speed of 10 m/s reaching heights of up to 40 m. We compare the speeds measured on the surface with (i) expected rising speeds of gas bubbles in water given a certain diameter and (ii) migration speeds derived from migrating seismic source locations. We discuss the derived height with respect to seismic amplitudes to constrain the tremor generation and to finally assess whether the seismic amplitude (e. g. RMS) has any predictive power when it comes to eruption forecasting.&amp;lt;/p&amp;gt;
Open Loop Power Control parameter settings impact on LTE HetNet uplink performance (2013)

Open Loop Power Control is an important technique providing adaptation of user transmit power. There are multiple factors like cell size, interference conditions, etc. that determine the optimal settings of power control (PC) parameters. In this paper, the impact of open loop PC parameter settings on the performance of LTE uplink (UL) in a co-channel heterogeneous network (HetNet) scenario with macro- and pico-cells is presented. Further, we study the difference in optimal PC settings for various network deployment scenarios and cell range extension (CRE) offsets in order to determine sensitivity of those parameter settings. It is found that optimal PC parameters for one case can serve as good parameters for other network configurations as well. The conclusions are supported by results of system-level simulations.
Asymmetrical Spatial Accuracy in 3D Tracking (1994)

This paper reports on asymmetrical spatial accuracy of human subjects in tracking of an object which moves randomly with 6 degrees-of-freedom (DOF) in a 3D environment. It was found that, for translational errors, RMS deviations in the depth (Z) direction were 40% higher than those in the horizontal (X) direction, for an experimental display which provided binocular disparity (stereopsis), perspective and partial occlusion cues. In general, translational tracking errors in the vertical (Y) direction were greater than those in the X direction and smaller than those in the Z direction. In early stages of practice, vertical errors were similar to those in the Z direction, but as learning progressed, errors in the X and Y dimensions converged. These finding were consistent across two types of controllers and different tracking paths in the 3D environment. It would appear that horizontal movement requires higher attentional resource priority over vertical movement in such a tracking task.
Simultaneous Localization and Mapping for Path-Constrained Motion (2011)

Accurate localization is a fundamental component of driver-assistance systems and autonomous vehicles. For path-constrained motion, a map offers significant information and assists localization with valuable information about the evolution of the kinematic vehicle states. We propose natural parameterized cubic spline curves to approximate true motion constraints, particularly the centerline of individual road lanes or rail tracks. Vehicle kinematics is modeled in 1-D curve coordinates. Since map information is subject to uncertainties, a probabilistic treatment is a prerequisite to obtaining consistent localization results. The proposed probabilistic curvemap (PCM) and the close map-to-vehicle relation enable a straightforward derivation of measurement update equations without additional map-matching steps and offer themselves to classical filter techniques. Incoming sensor measurements are used for simultaneous vehicle localization and local PCM update around the current vehicle position. Thus, every revisit of a location reduces uncertainty in the local PCM. Moreover, when no prior information is provided in the PCM, extrapolation is carried out to handle these situations with incomplete maps. The proposed filter is validated through simulations and real-world railway experiments.
Air-stable ternary organic solar cells achieved by using fullerene additives in non-fullerene acceptor-polymer donor blends (2023)

Addition of a fullerene derivative to a PBTATBT-4F:Y6 blend significantly enhances cell stability, which retained 90% of the initial PCEs (13–14%) even after storage in air for 6 months, compared to only 20% retention for the binary device.
Biaxial ellipsometry (2005)

Biaxial ellipsometry measures the optical constants of materials, anisotropic films, and stacks of anisotropic films. Materials of interest include birefringent crystals, polarizing materials and films, and the complex multilayer anisotropic structures used in liquid crystal displays. An approach using Mueller matrix imaging polarimetry to simultaneously measure and angularly resolve reflection and transmission over large solid angles is presented. Biaxial materials have three refractive indices and three absorption coefficients in orthogonal directions but with arbitrary orientation. Determination of the dielectric tensor provides a succinct and suitable material representation, and its accurate determination is the focus of this investigation.
Chelation-Induced Reversal of Negative Cation Transference Number in Ionic Liquid Electrolytes (2020)

Strong anion-cation interaction in lithium-salt/ionic liquid electrolytes leads to ionic association that decreases the Li transference number, even causing it to be negative. We show that these interactions can be greatly reduced by adding cyclic ethylene oxide molecules, and we quantitatively examine the effect using rigorous multispecies concentrated solution theory coupled with molecular dynamics simulations. The added molecules, primarily lithium ionophore V also known as 12-crown-4, have high affinity to lithium, therefore disrupting the lithium cation-anion coupling, resulting in a significantly improved transference number. First, we investigate the lithium-anion spatial correlation by studying their clusters and show that the 12-crown-4 ether allows the formation of previously nonexisting positively charged lithium-containing complexes. We then prove that the chelators actively compete with the anion to coordinate lithium ions by showing that the persistence-over-time of a given anion coordination cage decreases when ionophore molecules are added to the system. Last, we report an increase in the lithium transference number for a variety of chemistries as a function of added 12-crown-4 (and another ionophore, 18-crown-6) molecules, and even positive values can be reached. Our results provide a foundation for new design and optimization strategies to reverse the sign of and increase the transference number in highly correlated concentrated electrolytes.
Fibromyalgia Is Common in a Postpoliomyelitis Clinic (1995)

(1) Fibromyalgia occurs frequently in a postpolio clinic. (2) Fibromyalgia can mimic some symptoms of postpoliomyelitis syndrome. (3) Fibromyalgia in postpolio patients can respond to specific treatment.
A Parallel Numerical Method for Bio-Flow Analysis. (2001)

In this study a MIMD parallel numerical algorithm for computationally intensive bio-flow simulations has been proposed in the finite element framework. The segregated variable approach in conjunction with the domain decomposition strategy employed in the current parallel scheme is easy to implement, makes it amenable to handle complex bio-flow domains, and is less demanding on computational resources. The parallel method has been successfully tested in simulating hemodynamics in arteries with multiple aneurysms. Encouraging speedup and efficiency factors have been obtained in the parallel fem simulations.
ChemInform Abstract: Fully Selective Intramolecular ortho Photocycloaddition of 4‐(4‐ Methoxyphenoxy)‐3‐(N3‐benzoylthymin‐1‐yl)but‐1‐ene: An Unprecedented Benzene‐Thymine Photocycloaddition. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Influence of heat treatment on physical properties of In–Ga–Zn–O thin films (2015)

For unstable In–Ga–Zn–O (IGZO) thin films, electron-beam irradiation during transmission electron microscopy or heat treatment is reported to change the film structure and enhance its crystallization. Using IGZO films formed under two conditions, we study how the physical properties of IGZO films correlate with the electron-beam irradiation dose or heat-treatment temperature. IGZO films deposited under high deposition pressure contain many voids, have a relatively high impurity concentration, and are crystallized by electron-beam irradiation or heat treatment. In contrast, IGZO films formed under low deposition pressure are dense and the crystal size in the film does not change under electron-beam irradiation or heat treatment. In addition, heat treatment further increases the density of an originally dense film and reduces the defect density.
A Framework for IP and MPLS Fast Reroute Using Not-Via Addresses (2013)

This document presents an illustrative framework for providing fast
reroute in an IP or MPLS network through encapsulation and forwarding
to not-via addresses. The general approach described here uses a
single level of encapsulation and could be used to protect unicast,
multicast, and LDP traffic against link, router, and shared risk group
failure, regardless of network topology and metrics. The mechanisms
presented in this document are purely illustrative of the general
approach and do not constitute a protocol specification. The document
represents a snapshot of the work of the Routing Area Working Group at
the time of publication and is published as a document of record.
Further work is needed before implementation or deployment.
Cationic lipid complexed camptothecin (EndoTAG®-2) improves antitumoral efficacy by tumor vascular targeting (2007)

Neo-vascular targeting by cationic colloidal carriers enables to realize an innovative approach for tumor therapy. EndoTag-2 is a novel vascular targeting agent, comprising the mammalian topoisomerase I inhibitor camptothecin in its carboxylate form complexed to cationic lipid (cationic lipid complexed camptothecin). Here we studied tumor vascular targeting properties, antitumoral effects and mode of action of EndoTag-2. Tumor vascular targeting properties of fluorescently labelled EndoTag-2 were investigated by in vivo microscopy using A-MEL-3 tumors grown in the dorsal skinfold chamber preparation and by fluorescence histology of s.c. LLC-1 carcinomas. Therapeutic effects have been investigated in the s.c. LLC-1 carcinoma model and the L3.6pl human pancreatic cancer model implanted orthotopically in athymic nude mice. Antivascular effects have been studied by histological investigation of tumor microvessel density and non invasive investigation of tumor blood flow by dynamic contrast enhanced MRI imaging (DCE-MRI). EndoTag-2 selectively targeted tumor microvessels as confirmed by quantitative fluorescence microscopy. Compared to controls EndoTag-2 revealed remarkable antitumoral efficiency in s.c. LLC-1 carcinomas implanted in C57/Bl6 mice. Growth and metastasis of orthotopic L3.6pl human pancreatic tumors was significantly inhibited by EndoTag-2 treatment. Quantitative analysis of tumor microvessel density revealed significant reduction of microvessel density in lewis lung carcinomas up to 50%. DCE-MRI confirmed significant reduction of intratumoral vascular volume as well as tumor perfusion upon EndoTag-2 treatment. In conclusion this study shows that cationic lipid complexed camptothecin (EndoTag-2) is a markedly active antitumor agent based on an innovative vascular targeting approach.
Stability of thin film transistors incorporating a zinc oxide or indium zinc oxide channel deposited by a high rate sputtering process (2009)

A novel rf sputtering technology in which a high density plasma is created in a remote chamber has been used to reactively deposit zinc oxide (ZnO) and indium zinc oxide (IZO) thin films at room temperature from metallic sputtering targets at deposition rates ∼50 nm min−1, which is approximately an order of magnitude greater than that of rf magnetron sputtering. Thin film transistors have been fabricated using IZO with a maximum processing temperature of 120 °C, which is defined by the curing of the photoresist used in patterning. Devices have a saturated field effect mobility of 10 cm2 V−1 s−1 and a switching ratio in excess of 106. Gate bias stress experiments performed at elevated temperatures show a consistent apparent increase in the field effect mobility with time, which is attributed to a charge trapping phenomenon.
ChemInform Abstract: Free Radical Chemistry. Part 11. Additions of Cyclic and Acyclic Alcohols and Diols to Hexafluoropropene. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Estudio radiológico de la escoliosis. Curvas, ángulos y algo más. (2012)

Poster: SERAM 2012 / S-1054 / Estudio radiologico de la escoliosis. Curvas, angulos y algo mas. by: S. I. Sirvent, E. Garcia Esparza, M. A. Lopez Pino, I. Solis Muniz, G. Albi Rodriguez, G. Gomez Mardones; Madrid/ES
Design of Non-Cysteine-Containing Antimicrobial β-Hairpins:  Structure−Activity Relationship Studies with Linear Protegrin-1 Analogues (2002)

Protegrins are short, cationic peptides that display potent, broad-spectrum antimicrobial activity. PG-1, the first of the five natural analogues discovered, forms a rigid antiparallel two-stranded beta-sheet that is stabilized by two disulfide bonds. The two strands of the sheet are linked by a short two-residue loop segment. Removal of the disulfide bridges (e.g., in Cys --> Ala analogues) is known to cause marked loss of antimicrobial activity. We have used basic principles of beta-hairpin design to develop linear analogues of PG-1 that lack cysteine but nevertheless display PG-1-like activity. Our most potent reengineered molecules contain three essential design features: (i) the four cysteine residues of PG-1 are replaced by residues that have high propensity for beta-strand conformation, (ii) D-proline is placed at the i + 1 position of the reverse turn to promote a type II' beta-turn, and (iii) amino functionality is incorporated at the gamma-carbon of the D-proline residue to mimic the charge distribution of the natural beta-hairpin. Structural studies revealed that the antimicrobial potency of the non-disulfide-bonded peptides can be correlated to the stability of the beta-hairpin conformations they adopt in aqueous solution. The presence of 150 mM NaCl was found to have little effect on the antimicrobial activity of PG-1, but one of our linear analogues loses some potency under these high salt conditions. Despite this discrepancy in salt sensitivity, NMR and CD data indicate that neither PG-1 nor our linear analogue experiences a significant decrease in beta-hairpin conformational stability in the presence of 150 mM NaCl. Thus, salt inactivation is not due to destabilization of the beta-hairpin conformation. Furthermore, our results show that beta-sheet design principles can be used to replace conformation-stabilizing disulfide bridges with noncovalent conformation-stabilizing features.