gebhart/patrepeval huggingface dataset:
Size‐dependent effect of IgA on the IgA Fc receptor (CD89) (1997)

The IgA Fc receptor (FcR; CD89) is expressed on several types of cells of the myeloid cell lineage. We investigated whether different sizes of heat-aggregated IgA (aIgA) bind to CD89 and subsequently induce cellular activation. As a model we used the murine B cell line IIA1.6 transfected with CD89 or IIA1.6 cells transfected with CD89 as well as with the FcR gamma chain to study the binding of IgA to CD89. When these cells expressing CD89 were incubated with monomeric IgA, no significant binding of IgA to the cells was detectable by fluorescence-activated cell sorter analysis; however, incubation of the cells with aggregated IgA resulted in 93 +/- 2% positive cells. Incubation of the cells with different sizes of IgA-containing aggregates revealed optimal binding with aggregates containing five to six molecules of IgA per aggregate. No difference was observed between the binding to CD89 of both IgA1- or IgA2-containing aggregates. Furthermore, the binding of aIgA was found to be CD89-specific, since the binding of IgA was completely inhibited by the CD89-specific monoclonal antibody My43 and no detectable binding occurred to the IIA1.6 parent cell line. Activation studies using interleukin-2 (IL-2) production as a marker, showed that the FcR gamma chain is necessary to induce cellular activation. Only cells transfected with both CD89 and the FcR gamma chain (CD89+/gamma +) enhance the IL-2 production 10-12-fold upon stimulation with aggregates of IgA. Furthermore, triggering of CD89 only results in increase of intracellular calcium concentration ([Ca2+]i) in cells co-expressing FcR gamma chain. Mutation of the tyrosine residues in the FcR gamma chain immunoreceptor tyrosine-based activation motif of the FcR gamma chain abolishes this increase in [Ca2+]i, indicating association and involvement of the FcR gamma chain in CD89-mediated signaling.
Modeling Neural Mechanisms for Genesis of Respiratory Rhythm and Pattern. III. Comparison of Model Performances During Afferent Nerve Stimulation (1997)

The goal of the present study was to evaluate the relative plausibility of the models of the central respiratory pattern generator (CRPG) proposed in our previous paper. To test the models, we compared changes in generated patterns with the experimentally observed alterations of the respiratory pattern induced by various stimuli applied to superior laryngeal (SLN), vagus and carotid sinus (CS) nerves. In all models, short-duration SLN simulation caused phase-resetting behavior consistent with experimental data. Relatively weak sustained SLN stimulation elicited a two-phase rhythm comprising inspiration and postinspiration whereas a stronger stimulation stopped oscillations in the postinspiratory phase ("postinspiratory apnea"). In all models, sustained vagus nerve stimulation produced postinspiratory apnea. A short vagal stimulus delivered during inspiration terminated this phase. The threshold for inspiratory termination decreased during the course of the inspiratory phase. The effects of short-duration vagal stimulation applied during expiration were different in different models. In model 1, stimuli delivered in the postinspiratory phase prolonged expiration whereas the late expiratory phase was insensitive to vagal stimulation. No insensitive period was found in model 2 because vagal stimuli delivered at any time during expiration prolonged this phase. Model 3 demonstrated a short period insensitive to vagal stimulation at the very end of expiration. When phasic CS nerve stimulation was applied during inspiration or the first half of expiration, the performances of all models were similar and consistent with experimental data: stimuli delivered at the beginning inspiration shortened this phase whereas stimuli applied in the middle or at the end of inspiration prolonged it and stimuli delivered in the first half of expiration prolonged the expiratory interval. Behavior of the models were different when CS stimuli were delivered during the late expiratory phase. In model 1, these stimuli were ineffective or shortened expiration initiating the next inspiration. Alternatively, in models 2 and 3, they caused a prolongation of expiration. Although all CRPG models demonstrated a number of plausible alterations in the respiratory pattern elicited by afferent nerve stimulation, the behavior of model 1 was most consistent with experimental data. Taking into account differences in the model architectures and employed neural mechanisms, we suggest that the concept of respiratory rhythmogenesis based on the essential role of postinspiratory neurons is more plausible than the concept employing specific functional properties of decrementing expiratory (dec-E) neurons and that the ramp firing pattern of the late expiratory neuron is more likely to reflect intrinsic properties than disinhibition from the dec-E neurons.
Energy-Efficient Multiobjective Thermal Control for Liquid-Cooled 3-D Stacked Architectures (2011)

3-D stacked systems reduce communication delay in multiprocessor system-on-chips (MPSoCs) and enable heterogeneous integration of cores, memories, sensors, and RF devices. However, vertical integration of layers exacerbates temperature-induced problems such as reliability degradation. Liquid cooling is a highly efficient solution to overcome the accelerated thermal problems in 3-D architectures; however, it brings new challenges in modeling and run-time management for such 3-D MPSoCs with multitier liquid cooling. This paper proposes a novel design-time/run-time thermal management strategy. The design-time phase involves a rigorous thermal impact analysis of various thermal control variables. We then utilize this analysis to design a run-time fuzzy controller for improving energy efficiency in 3-D MPSoCs through liquid cooling management and dynamic voltage and frequency scaling (DVFS). The fuzzy controller adjusts the liquid flow rate dynamically to match the cooling demand of the chip for preventing overcooling and for maintaining a stable thermal profile. The DVFS decisions increase chip-level energy savings and help balance the temperature across the system. Our controller is used in conjunction with temperature-aware load balancing and dynamic power management strategies. Experimental results on 2-tier and 4-tier 3-D MPSoCs show that our strategy prevents the system from exceeding the given threshold temperature. At the same time, we reduce cooling energy by up to 63% and system-level energy by up to 21% in comparison to statically setting a flow rate setting to handle worst-case temperatures.
Assessment of non‐alcoholic fatty liver disease using serum total cell death and apoptosis markers (2012)

Cytokeratin-18 M30 and M65/M65ED have moderate accuracy in detecting non-alcoholic steatohepatitis. Changes in the biomarkers also correlate with histological progression. However, development of new biomarkers is still required to improve the diagnostic accuracy.
Multipath Extension for QUIC (1999)

This document specifies multipath extension for the QUIC protocol to
enable the simultaneous usage of multiple paths for a single
connection. The extension is compliant with the single-path QUIC
design. The design principle is to support multipath by adding limited
extension to [QUIC-TRANSPORT].
Precise Positioning in Alpine Areas with Troposphere and Multipath Estimation (2018)

Real-Time Kinematic (RTK) positioning with Global Navigation Satellite System (GNSS) signals is widely used, e.g. for surveying, agriculture, and potentially for autonomous vehicles and Unmanned Air Vehicles (UAVs) in the future. In this paper, an extended RTK positioning for significant height differences between two low-cost GNSS receivers with patch antennas is presented. In this case, the classical model for double difference measurements needs to be extended, i.e. a differential tropospheric zenith delay and pseudorange multipath errors need to be estimated besides the baseline and carrier phase integer ambiguities. The increased number of unknowns results in an ill-conditioned system of observation equations and a substantial correlation between the state estimates. We introduce prior information on the differential tropospheric zenith delay based on the differential air pressure, and exploit the temporal correlation of pseudorange multipath errors. Moreover, a criterion for the integer ambiguity candidate vector selection is provided, which is robust over phase multipath and unavoidable errors in the float ambiguity covariance matrix.
The proposed method is validated with two low-cost GNSS
modules that were placed at the Zugspitzplatt (2601 m a.s.l.) and Eibsee (1018 m a.s.l.). The obtained estimates for the baseline and differential tropospheric zenith delay show a high repeatability over several independent ambiguity fixings. The residuals of the fixed carrier phase measurements are within two centimeters for almost all satellites, which confirms both the measurement model and the ambiguity fixing.
What Is the Survivorship of Revision Surgery Performed for the Chronically Dislocated THA? (2018)

Level IV, therapeutic study.
Non-overlapping rings: A new architecture for designing switch clusters in data centers (2013)

The data center network is an important component of the modular cloud data center. Currently, a common architecture involves connecting servers in the data center by switches arranged in a generalized tree topology. However, cloud computing service providers are considering adding “east-west” horizontal links between top of rack (TOR) switches to improve latency performance and/or reducing cost between groups of TOR switches and to off-load traffic from the tree network. One possible method to achieve this involves connecting TOR switches into clusters. Some clusters would be designated as high performance clusters providing low latency, while other clusters would be optimized for cost, while still providing adequate latency performance. In this paper, we present an algorithm for designing lower-cost network clusters using non-overlapping rings (NOR). We describe some of the performance characteristics of these NOR clusters such as coverage vs. number of rings. We show that cost savings can be achieved with minimal increase in end-to-end delay, and that good performance can also be maintained under failure conditions. We also describe how incremental network growth can be easily accommodated using a smooth growth design through our algorithm. As cabling is a major practical consideration for cluster based architectures, we also define a simple cabling architecture for NOR networks.
Demonstration of using Passive Integrated Phase Masks to Generate Orbital-Angular-Momentum Beams in a Communications Link (2016)

We demonstrate high-efficient polarization insensitive OAM generation using integrated phase masks and measure their tolerance to the misalignment of incident beams. An 80 Gbit/s communication link of two OAM channels by using phase masks is demonstrated.
Simultaneous control over the molecular weight and tacticity of poly(vinyl acetate) using a low-temperature photoinitiated RAFT process in fluoroalcohols (2013)

A photoinitiated RAFT process in fluoroalcohols (FAs) was successfully applied to the preparation of poly(vinyl acetate) and its hydrolyzed polymer, poly(vinyl alcohol), permitting the simultaneous control over the molecular weight (MW) and tacticity. The polymerization reaction displayed living polymerization characteristics, evidenced with linear relationships between ln([M]0/[M]) and time, and between the MW and the conversion. Polymers of higher syndiotacticity could be prepared by using the FA solvent, achieving a 62.4% racemic diad at −20 °C. The syndiotacticity of the polymer increased with increasing concentrations of FAs or with decreasing polymerization temperatures, and the dependence was stronger than the one observed in conventional radical polymerization reactions due to the slower RAFT process. Furthermore, by performing a sequential polymerization reaction involving the high-temperature reaction in the bulk state and the low-temperature reaction in the FAs, stereoblock copolymers of poly(vinyl alcohol) could be obtained.
Plasma tumor necrosis factor-alpha during long-term endotoxemia in awake sheep (1992)

We used a continuous 12-h infusion of Escherichia coli endotoxin (10 ng.min-1.kg-1) in 10 awake sheep equipped with a lung lymph fistula and vascular catheters to determine the time course of increased plasma tumor necrosis factor-alpha (TNF-alpha) during the infusion and a 12-h postinfusion period. Lung lymph flow increased progressively during the infusion to a peak value averaging 8.6 +/- 2.0 times the baseline flow of 6.3 +/- 1.3 g/h. During the postinfusion period, lung lymph flow remained elevated at three to four times baseline. The lymph-to-plasma protein concentration ratio was unchanged from baseline over 24 h, indicating a dramatic increase in net protein flux across pulmonary microvessels. The TNF-alpha concentration peaked early in the infusion and then declined, despite the continuing presence of endotoxin. Plasma TNF-alpha concentration increased 10-fold (0.33 +/- 0.05 ng/ml at baseline to 3.89 +/- 0.78 ng/ml peak) 2 h into the endotoxin infusion. At the end of the endotoxin infusion, plasma TNF-alpha had decreased to 1.16 +/- 0.19 ng/ml. The circulating TNF-alpha concentration did not correlate with pathophysiology or outcome in these sheep.
Comparative modelling of water, saline and myocardium dielectric properties in the microwave spectrum (1995)

A two dimensional prototype of a quasi real-time microwave tomographic imaging system was constructed [Semenov, et al. (1)]. In order to correlate reconstructed microwave images with physiological changes of the tissue, theoretical analysis of the tissue dielectric properties have to be conducted. Theoretical modelling of the dielectric properties of deionized water, saline and myocardium is described. Analysis was performed at a frequency range from 0.2 to 6.0GHz and In temperature range between 32°C and 48°C. Dielectric properities of water were described on the basis of the Debay theory of relaxation as a one compound relaxation process. An ion conduction component was added to the imaginary part of the Debay equation for saline dielectric properties modelling. In addition to this, free water, bound water and protein components with correspondent volume fractions were added into the dielectric relaxation model of the myocardium. Water, saline and myocardium models were compared on the basis of experimental data fitting. The deviation between our model and experimental data was about 1.5% for both e' and e" for deionized water. Corresponding values for saline was about 2.0% and for myocardium was about 2.5%. These models were tested in various experiments with saline, diluted saline and myocardium. Information about the biophysical parameters of the samples was theoretically determined by our models. These parameters correlated with independently measured physiological data which allowed us to utilize the model for experimental data analysis at a frequency range from 0.2GHz to 6.0GHz.
Cardiometabolic risk management: insights from a European Society of Cardiology Cardiovascular Round Table (2023)

Metabolic comorbidities are common in patients with cardiorenal disease; they can cause atherosclerotic cardiovascular disease (ASCVD), speed progression, and adversely affect prognosis. Common comorbidities are Type 2 diabetes mellitus (T2DM), obesity/overweight, chronic kidney disease (CKD), and chronic liver disease. The cardiovascular system, kidneys, and liver are linked to many of the same risk factors (e.g. dyslipidaemia, hypertension, tobacco use, diabetes, and central/truncal obesity), and shared metabolic and functional abnormalities lead to damage throughout these organs via overlapping pathophysiological pathways. The COVID-19 pandemic has further complicated the management of cardiometabolic diseases. Obesity, T2DM, CKD, and liver disease are associated with increased risk of poor outcomes of COVID-19 infection, and conversely, COVID-19 can lead to worsening of pre-existing ASCVD. The high rates of these comorbidities highlight the need to improve recognition and treatment of ASCVD in patients with obesity, insulin resistance or T2DM, chronic liver diseases, and CKD and equally, to improve recognition and treatment of these diseases in patients with ASCVD. Strategies to prevent and manage cardiometabolic diseases include lifestyle modification, pharmacotherapy, and surgery. There is a need for more programmes at the societal level to encourage a healthy diet and physical activity. Many pharmacotherapies offer mechanism-based approaches that can target multiple pathophysiological pathways across diseases. These include sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, selective mineralocorticoid receptor antagonists, and combined glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist. Non-surgical and surgical weight loss strategies can improve cardiometabolic disorders in individuals living with obesity. New biomarkers under investigation may help in the early identification of individuals at risk and reveal new treatment targets.
B113 A study of a small nuclear power plant system for district heating (2008)

We have studied nuclear power plant for district heating. Already some towns and villages in Hokkaido have requested small reactor for district heating. Using existing technology allows us to shorten development period and to keep a lid on development cost. We decided to develop new reactor based on "MUTSU" reactor technology. "MUTSU" had already proved its safety. And "MUTSU" reactor was boron free reactor. It allows plant system to become more compact and simple. And load following capability by core reactivity become bigger. It means to reduce control rod movement It leads to dependability enhancement. We calculated burn-up calculation of erbium addition fuel. In the result the core life became about 10 years. In the district heating system, there are not only district heating but also snow melting with warm water. It uses steam condenser's heat, which are only discharged now. This small plant has passive safety system. It is natural cooling of containment vessel. In case of loss of coolant accident, decay heat can remove by natural convection air cooling after 6 hours. Decay heat within 6 hours can remove by evaporative heat transfer of pool on containment vessel.
How can we manage the cardiac toxicity of immune checkpoint inhibitors? (2021)

<b>Introduction</b>: Cancer immunotherapies with monoclonal antibodies (mAbs) against immune checkpoints (i.e. CTLA-4 and PD-1/PD-L1) have revolutionized antineoplastic treatments. Immune checkpoint inhibitors (ICIs) approved for cancer immunotherapy are mAbs anti-CTLA-4 (ipilimumab), anti-PD-1 (nivolumab, pembrolizumab, and cemiplimab), and anti-PD-L1 (atezolizumab, avelumab, and durvalumab). Treatment with ICIs can be associated with immune-related adverse events (irAEs), including an increased risk of developing myocarditis. These findings are compatible with the observation that, CTLA-4, PD-1, and PD-L1 pathways play a central role in the modulation of autoimmunity.<b>Areas covered</b>: In this paper, we start from examining the pathogenesis of cardiovascular adverse events from ICIs, and then we focus on risk factors and strategies to prevent and manage this cardiotoxicity.<b>Expert opinion</b>: There is a growing need for a multidisciplinary approach of ICI-associated cardiotoxicity, involving oncologists, cardiologists, and immunologists. Prevention and effective management of ICIs cardiotoxicity starts with an in-depth screening and surveillance strategies of high-risk patients, in order to improve early detection and appropriate management in a personalized approach.
A hidden Markov model for route and destination prediction (2017)

We present a simple model and algorithm for predicting driver destinations and routes, based on the input of the latest road links visited as part of an ongoing trip. The algorithm may be used to predict any clusters previously observed in a driver's trip history. It assumes that the driver's historical trips are grouped into clusters sharing similar patterns. Given a new trip, the algorithm attempts to predict the cluster in which the trip belongs. The proposed algorithm has low temporal complexity. In addition, it does not require the transition and emission matrices of the Markov chain to be computed. Rather it relies on the frequencies of co-occurrences of road links and trip clusters. We validate the proposed algorithm against an experimental dataset. We discuss the success and convergence of the algorithm and show that our algorithm has a high prediction success rate.
LGLC Laser Monolithically Integrated with Low-Loss, Dual-Core, Spot-Size Converter for Tunable XFP Modules (2011)

A tunable LGLC laser monolithically integrated with dual-core SSC for tunable XFP modules has been developed. FWHMs of horizontal and vertical FFPs were narrowed to 20° and 25° under 0.5dB low excess loss in C-band.
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma (2019)

Our results signify how non-tumour-intrinsic properties in the desmoplastic microenvironment can be exploited to reinstate immunosurveillance, providing readily translatable combination strategies to empower HCC immunotherapy.
Corrigendum: Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview (2023)

[This corrects the article DOI: 10.3389/fcell.2022.1107881.].
Low size dispersion of inas quantum islands emitting at 1.55μm on InP [001] (2003)

We show that the size dispersion of InAs/InP(00l) quantum islands emitting at 1.S5μm can be reduced through the optimization of SSMBE growth parameters. In optimized growth conditions, i.e. high Tc ~520°C and low P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">As</sub> = 2 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> torr leading to a 2D/3D growth mode transition measured by WEED at 1.8 ML, photoluminescence spectra with a FWHMs as low as 68meV at 300K have been obtained for a 4ML InSa deposit. Photoluminescence measurements as a function of the excitation power show that the multi-component PL spectra can be understood in terms of fundamental and excited levels of InAs islands. The fundamental peak (FWHM equal to 22meV at 8K) reveals a very low island size dispersion. Plane-view TEM and AFM images show that InAs islands are quantum << sticks >> aligned along [1-10], with flat top surfaces. Cross-section TEM imaging shows a very weak height dispersion attributed to the ability of the InAs/InP(00l) system to allow island height variation by monolayer fluctuation.
Editorial: Clinical prospective of SGLT2 inhibitors in atherosclerosis (2022)

EDITORIAL article Front. Cardiovasc. Med., 11 November 2022Sec. Clinical and Translational Cardiovascular Medicine https://doi.org/10.3389/fcvm.2022.1040649