gebhart/patrepeval huggingface dataset:
Identification of New Upregulated Genes with Possible Relevance for Multiple Myeloma Tumorigenesis (2008)

Abstract Serial analysis of gene expression (SAGE) allows a comprehensive profiling of gene expression within a given tissue and also an assessment of transcript abundance. Objectives: We generated SAGE libraries from normal and neoplastic plasma cells to identify genes differentially expressed in multiple myeloma (MM). Material and Methods: Normal plasma cells were obtained from palatine tonsils and MM SAGE library was generated from bone marrow plasma cells of MM patients. Results: We obtained 29,918 SAGE tags from normal and 10,340 tags from tumor libraries. Computer-generated genomic analysis identified 46 upregulated genes in the MM library. Ten upregulated genes were selected for further investigation. Differential expression was validated by quantitative real-time PCR in purified plasma cells of 31 patients and three controls. P53CSV, DDX5, MAPKAPK2, RANBP2 were found to be upregulated in at least 50% of the MM cases tested. All of them were also found upregulated in MM when compared to normal plasma cells in a meta-analysis using ONCOMINE microarray database. Antibodies specific to DDX5, RANBP2 and MAPKAPK2 were used in a TMA containing 57 MM cases and confirmed the expression of these proteins in 74, 96, and 21% of the MM samples, respectively. Conclusions: Analysis of differential expression using SAGE could identify new genes important for myeloma tumorigenesis (P53CSV, DDX5, MAPKPK2 and RANBP2) and that could potentially be useful as therapeutic targets.
Deliberately Designed Atomic-Level Silver-Containing Interface Results in Improved Rate Capability and Utilization of Silver Hollandite for Lithium-Ion Storage (2017)

α-MnO<sub>2</sub>-structured materials are generally classified as semiconductors; thus, we present a strategy to increase electrochemical utilization through the design of a conductive material interface. Surface treatment of silver hollandite (Ag<sub>x</sub>Mn<sub>8</sub>O<sub>16</sub>) with Ag<sup>+</sup> (Ag<sub>2</sub>O) provides significant benefits to the resultant electrochemistry, including a decreased charge-transfer resistance and a 2-fold increase in deliverable energy density at a high rate. The improved function of this designed interface relative to conventional electrode fabrication strategies is highlighted.
Alemtuzumab consolidation in chronic lymphocytic leukaemia: a phase I/II multicentre trial (2016)

The results provide a safe and efficient schedule with weekly intravenous application of 10 mg of alemtuzumab as a consolidation regime in patients with CLL.
Strain measurement using oscillator circuit sensor with high sampling frequency (2019)

A strain measurement system based on astable multivibrator using CMOS inverter has been developed. This system could omit an amplifier, filter and A/D converter unlike conventional Wheatstone bridge type sensor, because strain is measured by counting frequency of circuit voltage output due to resistance changes of a strain gauge. In the previous studies, it was shown that static strain could be measured with the same level of accuracy as Wheatstone bridge circuit. However, it was found that the sampling frequency for counting was not high (around 1 Hz) and it was difficult to measure dynamic strain. A reciprocal counting method has been applied to the system to improve sampling frequency in this study. Fatigue tests of a notched specimen were carried out and strain was measured during the tests to compare performance between the developed sensor and original sensor. As a result, strain could be measured with high frequency by the developed sensor. It is also found that strain measurements with high frequency could detect crack propagation state during the fatigue tests.
Resonance shifts in the excitation of the n = 0, K = 1 to 6 quadrupolar resonances for ions confined in a linear ion trap (2002)

Experiments examining the excitation of the quadrupolar n = 0, K = 1 to 6 resonances for the ion reserpine in a linear ion trap have been shown to produce resonance shifts that were dependent upon either or both of the excitation amplitude and trap pressure (Collings, B. A.; Douglas, D. J. J. Am,. Soc. Mass Spectrom., 2000, 11, 1016-1022). The extent of this dependency was determined by examining the effects of each parameter using an ion trajectory simulator. The simulations indicated that it is the change in excitation amplitude that is mostly responsible for the resonance shifts with a minor dependency upon the trapping pressure. It was found that the higher excitation amplitudes required to observe the higher order resonances resulted in greater shifts relative to the theoretical resonances predicted for an excitation amplitude of zero volts. The nature of these shifts can be understood by examining the equations of motion for an ion trapped in a quadrupolar potential during the excitation process. Rearrangement of the equations of motion lead to a Mathieu stability diagram in which the coordinate and ordinate variables are dependent upon the excitation frequency and amplitude. In such a diagram the resonances occur in the regions of instability. The calculated resonance shifts showed good correlation with the experimental and simulation results.
Technological Development for Interfacing Parallel Access Memories to Parallel Computers. (1999)

Abstract : During this AASERT program, we have carried out the fabrication and evaluation of high speed receiver circuits implemented with this technology. To demonstrate the providing a bandwidth of 9GHz and an 8x8 III-V active-pixel sensor array with 285 MHz operation, In the following we present a complete characterization of this smart pixel technology, including the S- and Y-parameters extraction for the typical devices implemented by this technology.
Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals (2012)

Our results confirm that most of the tested lipid loci are associated with lipid traits in the Japanese, further indicating that in genetic susceptibility to lipid levels and CAD, the related metabolic pathways are largely common across the populations, while causal variants at individual loci can be population-specific.
Three-dimensional model of electron beam generated plasma (2017)

A three-dimensional model for magnetized electron beam generated plasma is described, which includes a coupled fluid simulation of the bulk plasma and a Monte Carlo model for beam electrons. A modified form of the classical expressions for magnetized-plasma electron transport coefficients is used in the fluid plasma model. The plasma model is calibrated and validated using Langmuir probe measurements in a cylindrical electron beam generated plasma, where the beam is launched parallel to the magnetic field. The electron density (ne) and temperature (Te) are measured along and across the beam for several gas pressures and magnetic fields in Ar. The validated plasma model is then used to examine a three-dimensional electron beam generated plasma system. Generally, plasma densities are on the order of 1016 m−3 and, since there is no externally applied electric field in the plasma region, Te is below 1.25 eV in Ar. The chamber in the simulation is slightly asymmetric perpendicular to the axis of the electron beam and the magnetic field. This asymmetry combined with the E × B drift produce non-uniformities in the plasma even if the magnetic field is spatially uniform in the chamber. However, the cross-field plasma uniformity can be controlled by tailoring the magnetic field profile to enhance or reduce plasma production near the periphery of the chamber.
ChemInform Abstract: INTRA‐ AND INTERMOLECULAR ORGANOACTINIDE CARBON‐HYDROGEN ACTIVATION PATHWAYS. FORMATION, PROPERTIES, AND REACTIONS OF THORACYCLOBUTANES (1983)

Abstract Die Thermolyse der Bis‐[neopentyloder trimethylsilylmethyl]‐Th‐Verbindung (I) führt unter γ‐C‐H‐Entzug zu den Thora‐ Wclobutanen (H).
Type 2 Diabetes: Local Inflammation and Direct Effect of Bacterial Toxic Components (2008)

Objectives: It has been known for almost a century that amyloidosis is frequently associated with chronic bacterial infection. Islet amyloid deposit is characteristic of type 2 diabetes. Periodontal disease, which is predominantly caused by several Gram negative bacteria, is a risk factor for type 2 diabetes. The goal of the study was to explore whether bacteria or their toxic components may play a role in type 2 diabetes.
ChemInform Abstract: SYNTH. VON ANALGETICA 34. MITT. SYNTH. VON 3‐HYDROXY‐N‐CYCLOPROPYLMETHYL‐9‐AZAMORPHINAN (UNTERSUCHUNGEN UEBER DIE SYNTH. HETEROCYCLISCHER VERBINDUNGEN 509. MITT.) (1973)

Abstract 2‐Benzyloxychlorbenzol (I) liefert über das Dehydrobenzol mit Cyclohexanon (II) das substituierte Cyclohexanon (III), das mit Bromessigester zu (IVa) substituiert und dann zu (IVb) verseift wird.
Enhancement of Tendon-Bone Integration of Anterior Cruciate Ligament Grafts with Bone Morphogenetic Protein-2 Gene Transfer (2002)

Novel technologies including gene therapy and tissue engineering, such as those described in this study, may provide useful therapeutic procedures to enhance biological healing after reconstruction of the anterior cruciate ligament.
ChemInform Abstract: The Chemical Stability of Sodium Beta′′‐Alumina Electrolyte in Sulfur/Sodium Polysulfide Melts (1988)

Abstract of different compositions (Na 2 S 2 , Na 2 S 3 , Na 2 S 4 , Na 2 S 5 , pure sulfur) is investigated at Na/S battery operation temperatures.
Reflection quasilattices and the maximal quasilattice (2016)

We introduce the concept of a reflection quasilattice, the quasiperiodic generalization of a Bravais lattice with irreducible reflection symmetry. Among their applications, reflection quasilattices are the reciprocal (i.e., Bragg diffraction) lattices for quasicrystals and quasicrystal tilings, such as Penrose tilings, with irreducible reflection symmetry and discrete scale invariance. In a follow-up paper, we will show that reflection quasilattices can be used to generate tilings in real space with properties analogous to those in Penrose tilings, but with different symmetries and in various dimensions. Here we explain that reflection quasilattices only exist in dimensions two, three, and four, and we prove that there is a unique reflection quasilattice in dimension four: the ``maximal reflection quasilattice'' in terms of dimensionality and symmetry. Unlike crystallographic Bravais lattices, all reflection quasilattices are invariant under rescaling by certain discrete scale factors. We tabulate the complete set of scale factors for all reflection quasilattices in dimension $d&gt;2$, and for all those with quadratic irrational scale factors in $d=2$.
640 x 480 pace HgCdTe FPA development for high performance FLIRs (1992)

A hybrid 640 x 480 PACE HgCdTe FPA is being developed to meet the needs of many applications including missile seekers and FLIR's. The device will offer full TV resolution with sensitivity much superior to PtSi, having over one-quarter million pixels. The hybrid is comprised of a PACE HgCdTe detector array having nominal 5 pm cut- off wavelength, mated to a high speed CMOS readout having high charge-handling capacity. The HgCdTe detectors are being fabricated on alternative sub- strates using Rockwell's mature PACE-1 and advanced PACE-3 detector growth processes. The PACE-3 process, which is currently being developed, involves the MOCVD of HgCdTe on buffered silicon sub- strates. Since a PACE-3 hybrid uses silicon substrates for both the readout and detector, excellent hybrid reliability is expected even after thousands of thermal cycles. Based on 2562 results to date, the PACE-3 detectors will have mean quantum efficiency &lt; 30% with rms respons- ivity nonuniformity &lt; 8% across a typical array. The mean detector RoA product measured on parallel test samples is typically greater than 104 sl-cm2 at 80K. PACE-1 detectors in this cell size have RoA &lt; 105 o-cm2 at 80K and quantum efficiency &lt; 60%. The 640 x 480 readout uses a CMOS switched-FET architecture with direct injection input. The device is structured in four quadrants and has four high speed outputs. The unit cell size is 27 x 27 um 2. Included in the cell is a built-in test feature allowing full readout characterization prior to hybridization. Maximum data rate of each output is &lt; 10 MHz. The 640 x 480 thus generates over 109 bits/sec of video information. The chip was fabricated using 1.25 um lithography at a silicon foundry. Very good functional yield of the &lt; 3 cm2 dice was achieved.
Elevated Serum Megakaryocyte Potentiating Factor as a Predictor of Poor Survival in Patients with Mesothelioma and Primary Lung Cancer (2018)

The MPF assay has robust technical characteristics, with strong analytic and clinical validation. Clinical studies indicate that increased serum MPF is a predictor of poor survival for MM patients, throughout the course of the disease. Increased MPF is also associated with poor overall survival for patients with newly diagnosed lung cancer.
Optimized BIST Strategies for Programmable Data Paths Based on Cellular Automata (2005)

In this paper, optimized test methodologies will be presented for the generation of a set of predetermined test vectors on chip to be used as part of a BIST strategy for complex programmable data paths. For this purpose, use has been made of a cellular automaton. CAST-2 accomplishes the synthesis of the cellular automaton and the self-test control logic, and evaluates the obtained cellular-automata based solution. Dedicated test strategies for one-pattern tests on the one hand and one- and two-pattern tests on the other hand have been developed. These optimized techniques guarantee a BET implementation with 100 % stuck-at and stuck-open/close fault coverage for all detectable faults. The method has been applied to the data paths of an industrial-size speech processing application, developed with the silicon compiler CATHEDRAL-11. The total data path self-test overhead in terms of area is economically acceptable in practice.
Application of through mold via (TMV) as PoP base package (2008)

In recent years, package-on-package (PoP) has been rapidly adopted for 3D integration of logic and memory within mobile handsets and other portable multimedia devices. However, existing methods of making the PoP base package may not satisfy next generation applications that will require reduced memory interface pitches, higher memory interface pin-counts, reduced thickness, tight warpage control and higher levels of integration within the PoP base package. This paper introduces a new PoP base package structure that addresses the challenges of next generation applications. A PoP base package with through mold vias (TMV) will be described. Package flatness and package stacking results will be presented and advantages of TMV technology will be reviewed.
Gluconeogenesis in rat liver parenchymal cells in primary culture: Permissive effect of the glucocorticoids on glucagon stimulation of gluconeogenesis (1981)

Primary cultures of parenchymal cells isolated from adult rat liver by a collagenase perfusion procedure and maintained as a monolayer in a serum-free culture medium were used to study gluconeogenesis and the role that the glucocorticoids play in the control of this pathway. These cells carried out gluconeogenesis from three-carbon precursors (alanine and lactate) in response to glucagon and dexamethasone added alone or in combination. Maximum glucose production was observed with cells pretreated for several hours with dexamethasone and glucagon prior to addition of substrate and glucagon (8- to 12-fold increase over basal glucose production). Half-maximum stimulation of gluconeogenesis was seen with 3.6 X 10(-10) M glucagon and 3.6 X 10(-8) M dexamethasone. Maximum stimulation was observed with 10(-7) M glucagon and 10(-6) M dexamethasone. The length of time of dexamethasone pretreatment was found to be important in demonstrating the effect of glucocorticoids on glucagon-stimulated gluconeogenesis. Treatment of cells with dexamethasone for 2 hours did not result in an increase in glucose production over identical experimental conditions in the absence of dexamethasone, whereas pretreatment for 5 hours (1.2-fold increase) or 15 hours (1.7-fold increase) did result in an increase in glucose production. The results establish that the adult rat liver parenchymal cells in primary culture are a valid model system to study hepatic gluconeogenesis. In addition, we have established directly that the glucocorticoids amplify the glucagon stimulation of gluconeogenesis.
Function-Oriented Synthesis: Biological Evaluation of Laulimalide Analogues Derived from a Last Step Cross Metathesis Diversification Strategy (2008)

Laulimalide is a potent microtubule stabilizing agent and a promising anticancer therapeutic lead. The identification of stable, efficacious and accessible analogues is critical to clinically exploiting this novel lead. To determine which structural features of laulimalide are required for beneficial function and thus for accessing superior clinical candidates, a series of side chain analogues were prepared through a last step cross metathesis diversification strategy and their biological activities were evaluated. Five analogues, differing in potency from 233 nM to 7.9 muM, effectively inhibit cancer cell proliferation. Like laulimalide, they retain activity against multidrug resistant cells, stabilize microtubules and cause the formation of aberrant mitotic spindles, mitotic accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Structural modifications in the C 23-C 27 dihydropyran side chain can be made without changing the overall mechanism of action, but it is clear that this subunit has more than a bystander role.
Stereoselective Synthesis of (2S, 5R)-2-Methyl-5-Hexanolide, Enantiomer of the Carpenter Bee Sex Pheromone (1993)

Abstract A synthesis of (2S, 5R)-2-methyl-5-hexanolide (1) (the enantiomer of the carpenter bee sex pheromone) is presented starting from D-glucose. The required C-2 methyl group has been introduced in a key step stereoselectively, using the cross coupling reaction of 2-allyl-thiobenzothiazole derivatives with methyl cuprates.
Finite Rate Feedback Design for Multiple Transmit Antennas (2002)

Most practical systems employ a feedback channel to convey the channel state information to the transmitter.In this work, we address the problem of designing feedback, with constraints on the feedback rate, for a multiple transmit antenna system employing transmit beamforming with a single receiver antenna.The important contribution of this work is a design criterion for construction of a finite set of beamformers which leads to near optimal outage performance.
Direct Amino Acid Catalyzed Asymmetric α Oxidation of Ketones with Molecular Oxygen. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Fatal pulmonary embolism after arthroscopic rotator cuff repair: a case series (2019)

Background: pulmonary embolism (PE) is a rare and serious complication of arthroscopic orthopaedic surgery. Currently there is great paucity in the literature regarding PE events following arthroscopic rotator cuff (ARCR) surgery. The purpose of this case series was to (1) report our known incidence rate of symptomatic PE following ARCR for a single surgeon and (2) describe five cases of pulmonary embolism following AR-CR, detailing patient medical history and potential perioperative risk factors. Methods: the number of PE events were queried retrospectively from the institutional database with the ICD-9 code 415.1 within a 10 year time frame (2003-2013). Cases of PE identified by ICD-9 query were reviewed for type of procedure, postoperative day of event, and surgeon. Only patients with a confirmed diagnosis by computed tomography (CT) scan or post-mortem exam, were included in this study. Patient medical records belonging to affected patients were ordered and reviewed by a single investigator. Pre, intra, and postoperative information was obtained and summarized.
Ferromagnetic Copper(II) Complex Containing Ferrocenecarboxylato Bridging Ligands (2000)

The synthesis and characterization of the copper(II) complex [Cu2(dpt)2{(μ-O2C)[(η5-C5H4)Fe(η5-C5H5)]}2](ClO4)2 (1), where dpt = dipropylenetriamine, are reported, and its structure was determined by single-crystal X-ray analysis. The compound crystallizes in the monoclinic system, space group P21/n, with a = 9.920(2) Å, b = 12.925(2) Å, c = 15.768(3) Å, β = 93.17(1)°, and Z = 2. The cationic part of 1 shows a tetrametallic core in which two ferrocenecarboxylato groups act as (O,O‘) bridging ligands between two copper(II) ions with a square-pyramidal environment. Susceptibility measurements on this compound indicate a ferromagnetic, albeit weak, coupling between the two paramagnetic centers, with best-fit values of J = +2.5(3) cm-1 and giso = 2.12(1). Magnetostructural correlations can be qualitatively explained on the basis of the topology of their chairlike core. A quantitative investigation has been performed by means of ab initio density functional theory based calculations in the broken-symmetry approach.
Use of an Alumina-on-Alumina Bearing System in Total Hip Arthroplasty for Osteonecrosis of the Hip (2006)

Therapeutic Level III. See Instructions to Authors on jbjs.org for a complete description of levels of evidence.
Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets (2016)

Diabetic neuropathy subsequent to chronic high blood glucose-induced nerve damage is one of the most frustrating and debilitating complications of diabetes, which affects the quality of life in patients with diabetes. Approximately 60-70% of patients with diabetes suffer from a distal symmetrical form of mild to severe neuropathy that progresses in a fiber-length-dependent pattern, with sensory and autonomic manifestations predominating. High glucose and oxidative stress-mediated damage in neurons and glial cells, as well as neuroinflammation and crosstalk between these disease processes, have garnered immense attention as the essential mechanisms underlying the development and progression of diabetic neuropathy. Although the metabolic causes of diabetic neuropathy are well understood and documented, treatment options for this disorder are still limited, highlighting the need for further studies to identify new molecular and therapeutic targets. This review covers recent advances in our knowledge of the pathophysiology of diabetic neuropathy, discusses how persistent hyperglycemic conditions and malfunctioning glia drive disease progression, and finally explores the possibilities and challenges offered by several potential novel therapeutic targets for both preventing and reversing diabetic neuropathy.
Application of liquid crystal on silicon Spatial Light Modulator (LCOS-SLM) for manipulation and sensing (2015)

A high performance 2D Spatial Light Modulator named LCOS-SLM has been developed for wide range usefulness from basic researches to practical applications. We show the fundamental characteristics of LCOS-SLM device we developed, and introduce the activity examples such as the scientific researches of singular optics, fluorescence microscopy and adaptive optics. We have also applied this device for several industrial and medical applications.