gebhart/patrepeval huggingface dataset:
Clinical features of hepatitis B and C virus infections, with high α-fetoprotein levels but not hepatocellular carcinoma (2017)

The appropriate α-fetoprotein (AFP) level to confirm hepatocellular carcinoma (HCC) could be 100 ng/mL; however, the clinical significance of falsely elevated AFP in patients without HCC has not been fully studied. We investigated the clinical features and outcome of patients without HCC but with high AFP levels (100 ng/mL), especially with chronic hepatitis B (CHB) or C (CHC).The sample included 124 consecutive patients with CHB (n = 97) or CHC (n = 27), with AFP levels >100 ng/mL and without HCC at baseline. Multivariate Cox proportional regression analysis was performed to determine the factors associated with AFP normalization and HCC development.During the mean 52-month follow-up, the proportion of patients with CHB with AFP normalization (90.7%) was significantly higher than the proportion of patients with CHC (59.3%, P < 0.001). Initial aspartate aminotransferase levels (hazard ratio [HR] = 1.02 per 10 U/L increase, P = 0.021) and antiviral therapy (HR = 2.89, P < 0.001) were significantly associated with AFP normalization. Of the 16 (12.9%) patients who developed HCC, hepatitis B virus infection (HR = 10.82, P = 0.001), initiation of antiviral treatment postenrollment (HR = 0.23, P = 0.030), and AFP normalization within 12 months (HR = 0.13, P = 0.011) were associated with HCC development.CHB and CHC were the most common causes of falsely elevated AFP (>100 ng/mL). With either CHB or CHC, persistent AFP elevation (>12 months), regardless of antiviral treatment, might be an important marker of HCC development.
Stress-activated Protein Kinase-3 Interacts with the PDZ Domain of α1-Syntrophin (1999)

Mechanisms for selective targeting to unique subcellular sites play an important role in determining the substrate specificities of protein kinases. Here we show that stress-activated protein kinase-3 (SAPK3, also called ERK6 and p38gamma), a member of the mitogen-activated protein kinase family that is abundantly expressed in skeletal muscle, binds through its carboxyl-terminal sequence -KETXL to the PDZ domain of alpha1-syntrophin. SAPK3 phosphorylates alpha1-syntrophin at serine residues 193 and 201 in vitro and phosphorylation is dependent on binding to the PDZ domain of alpha1-syntrophin. In skeletal muscle SAPK3 and alpha1-syntrophin co-localize at the neuromuscular junction, and both proteins can be co-immunoprecipitated from transfected COS cell lysates. Phosphorylation of a PDZ domain-containing protein by an associated protein kinase is a novel mechanism for determining both the localization and the substrate specificity of a protein kinase.
Morphological Stability during Electrodeposition (2003)

Common experience shows that electrodeposited (ED) metallic films exhibit rough surfaces unless the electrochemical bath contains small quantities of molecular additives. We develop a formalism for describing the effects of additives on surface morphology evolution, which builds on that in a companion paper for the additive-free case. We demonstrate that the additives suppress the morphological instability that leads to roughening by preferentially accumulating near surface protrusions and blocking growth sites. Our chemically based model shows that additives which readily adsorb onto the surface and have a strong tendency to complex with the metal cations reduce the driving force for the instability and thus enhance leveling. Furthermore, polar additives provide an additional stabilizing effect, in accord with experimental observations. It is also shown that linearly stable growth can be achieved over a wide range of deposition flux at sufficiently large additive bulk concentrations. We predict the ED conditions necessary for growing flat films and demonstrate that these are in good agreement with experimental observations. © 2003 The Electrochemical Society. All rights reserved.
Dickkopf-Related Protein 1 Inhibits the WNT Signaling Pathway and Improves Pig Oocyte Maturation (2014)

The ability to mature oocytes in vitro provides a tool for creating embryos by parthenogenesis, fertilization, and cloning. Unfortunately the quality of oocytes matured in vitro falls behind that of in vivo matured oocytes. To address this difference, transcriptional profiling by deep sequencing was conducted on pig oocytes that were either matured in vitro or in vivo. Alignment of over 18 million reads identified 1,316 transcripts that were differentially represented. One pathway that was overrepresented in the oocytes matured in vitro was for Wingless-type MMTV integration site (WNT) signaling. In an attempt to inhibit the WNT pathway, Dickkopf-related protein 1 was added to the in vitro maturation medium. Addition of Dickkopf-related protein 1 improved the percentage of oocytes that matured to the metaphase II stage, increased the number of nuclei in the resulting blastocyst stage embryos, and reduced the amount of disheveled segment polarity protein 1 protein in oocytes. It is concluded that transcriptional profiling is a powerful method for detecting differences between in vitro and in vivo matured oocytes, and that the WNT signaling pathway is important for proper oocyte maturation.
VUV-optical oscillator strength distributions of C2H6O and C3H8O isomers (1986)

The photoabsorption cross sections of C2H6O isomers (ethyl alcohol and dimethyl ether) and C3H8O isomers (n-propyl alcohol, isopropyl alcohol, and ethyl methyl ether) have been measured in the wavelength region from 30 nm to the ionization potential of each molecule (about 120–130 nm) using an ionization chamber. The obtained photoabsorption cross sections show a maximum value at about 70–80 nm for each molecule. In the wavelength region shorter than about 50 nm, the cross sections are almost the same among isomers and equal to the sum of the cross sections for the constituent atoms. In the longer wavelength region, however, the cross sections show different peaks and shoulders depending on its molecular structure. Especially in the cases of dimethyl ether and ethyl methyl ether vibrational structures of the cross section are observed in the wavelength region from 70 to 100 nm.
48‐3: Invited Paper: Fiber‐Laser Processing of Si and IGZO Films for Advanced AMOLED Displays on Gen 8 Substrates (2022)

This paper reports on the microstructure of SBA‐crystallized polycrystalline Si films and discusses the potential application of SBA for annealing of amorphous IGZO films. A comparison of the crystallized Si films to those produced using ELA reveals that these strikingly differently generated materials are essentially microstructurally identical. We note that SBA (1) accomplishes the feat while providing certain benefits that address the manufacturing‐related ELA issues regarding operating costs and laser mura, (2) can be configured to execute SLS for realizing high‐mobility TFTs, and (3) may further be utilized for optimal heat treatment of IGZO and other materials.
Nucleic Acids of Species of Lactobacillus (1985)

Nucleic acid composition of 17 cultures representing the type or neotype strains of 15 named Lactobacillus species was studied. Nucleic acid characterization of these isolates was accompanied by a comparative study of conventional phenotypic reactions. The overall guanine plus cytosine mean deoxyribonucleic acid base composition ranged from 33 to 50% and genome sizes varied between 700 and 1500 X 10(6) daltons. Sporolactobacillus inulinus contained 2500 X 10(6) daltons of chromosomal deoxyribonucleic acid and was therefore similar in size to members of the genus Bacillus. Deoxyribonucleic acid hybridization at a temperature 15 degrees C below the thermal melting temperature confirmed the extreme molecular heterogeneity of many species. The genus can be divided into three major groups, each containing four or more species based on a combination of nucleic acid characteristics and conventional phenotypic reactions. Group I (33 to 39% guanine plus cytosine) contains Lactobacillus jensenii, Lactobacillus helveticus, Lactobacillus helveticus nov. ssp. jugurt, Lactobacillus acidophilus, Lactobacillus salivarius, and Lactobacillus sanfrancisco. Group II (42 to 48% guanine plus cytosine contains Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus brevis, and Group III (48 to 50% guanine plus cytosine) contains Lactobacillus delbrueckii, Lactobacillus delbrueckii nov. ssp. bulgaricus, Lactobacillus delbrueckii nov. ssp. lactis, Lactobacillus delbrueckii nov. ssp. leichmanii, Lactobacillus fermentum, and Lactobacillus fermentum nov. ssp. cellobiosis.
Mutations in the CRB1 Gene Cause Leber Congenital Amaurosis (2001)

Molecular diagnosis can confirm and clarify the diagnosis in an increasing fraction of patients with LCA. As genotype data accumulate, clinical phenotypes associated with specific mutations may be established. This will facilitate the counseling of patients regarding their visual prognosis and the likelihood of associated systemic anomalies.
DeepHull: Fast Convex Hull Approximation in High Dimensions (2022)

Computing or approximating the convex hull of a dataset plays a role in a wide range of applications, including economics, statistics, and physics, to name just a few. However, convex hull computation and approximation is exponentially complex, in terms of both memory and computation, as the ambient space dimension increases. In this paper, we propose DeepHull, a new convex hull approximation algorithm based on convex deep networks (DNs) with continuous piecewise-affine nonlinearities and nonnegative weights. The idea is that binary classification between true data samples and adversarially generated samples with such a DN naturally induces a polytope decision boundary that approximates the true data convex hull. A range of exploratory experiments demonstrates that DeepHull efficiently produces a meaningful convex hull approximation, even in a high-dimensional ambient space.
A Rat Model of Preeclampsia (2005)

Preeclampsia/eclampsia is a disorder of human pregnancy that continues to exact significant maternal morbidity and mortality and fetal wastage. Therapy of these disorders has not changed in over 50 years and there are no proven preventive measures. We describe a model of the development of a syndrome in the pregnant rat that resembles preeclampsia, which results from the imposition of excessive volume expansion early in gestation. We administered desoxycorticosterone acetate (DOCA) to pregnant animals whose drinking water had been replaced with saline. We compared the results obtained in these animals with those resulting from the study of control, virgin animals, virgin animals receiving DOCA and saline, and normal pregnant (NP) animals. The virgin animals given DOCA and saline did not become hypertensive. The experimental paradigm in the DOCA plus saline pregnant (PDS) animals provides many of the phenotypic characteristics of the human disorder including the development of hypertension, proteinuria, and intrauterine growth restriction. In addition, the mean blood nitrite/nitrate concentration was reduced in the PDS rats compared with their NP counterparts. We propose that this model may prove to be useful in the study of the human condition.
Issues for Pd2Si and NiSi Fully Silicided Gate Formation (2007)

Introduction Recently, parasitic components which degrade CMOS device performance are becoming more serious. One of them is gate depletion. To solve this problem, metal gate technology which replaces conventional poly-Si, is investigated. For current CMOS devices, p/n-poly Si gate, that is dual gate, is indispensable to obtain appropriate Vth. We are investigating workfunction tuning to obtain dual workfunction with single metal. Fully Silicided (FUSI) process meets such a target, since impurities implanted into poly-Si prior to silicidation forms pileup at the silicide/SiO2 interface by the snowplow effect and modify workfunction, as illustrated in Fig. 1. Although NiSi is the most popular for FUSI process, Pd2Si is also notable. It is superior to NiSi in terms of lower silicidation temperature and higher thermal stability. NiSi and Pd2Si workfunction tuning ranges reported in our previous literatures are summarized in Fig. 2. Although the range is narrower than one for the dual gate poly-Si, workfunction can be tuned in wide range and it is applicable to high Vth purpose such as low stand-by power devices. However, several issues concerning FUSI process were pointed out. In this paper, firstly defects found in in NiSi and Pd2Si are introduced and then influences on silicidation of temperature and impurity are discussed.
New Radio Beam-based Access to Unlicensed Spectrum: Design Challenges\n and Solutions (2018)

This paper elaborates on the design challenges, opportunities, and solutions\nfor New Radio-based access to Unlicensed spectrum (NR-U) by taking into account\nthe beam-based transmissions and the worldwide regulatory requirements. NR-U\nintends to expand the applicability of 5th generation New Radio access\ntechnology to support operation in unlicensed bands by adhering to\nListen-Before-Talk (LBT) requirements for accessing the channel. LBT was\nalready adopted by different variants of 4th generation Long Term Evolution\n(LTE) in unlicensed spectrum, i.e., Licensed-Assisted Access and MulteFire, to\nguarantee fair coexistence among different radio access technologies. In the\ncase of beam-based transmissions, the NR-U coexistence framework is\nsignificantly different as compared to LTE in unlicensed spectrum due to the\nuse of directional antennas, which enhance the spatial reuse but also\ncomplicate the interference management. In particular, beam-based transmissions\nare needed in the unlicensed spectrum at millimeter-wave (mmWave) bands, which\nis an attractive candidate for NR-U due to its large amount of allocated\nspectrum. As a consequence, some major design principles need to be revisited\nto address coexistence for beam-based NR-U. In this paper, different problems\nand the potential solutions related to channel access procedures, frame\nstructure, initial access procedures, re-transmission procedures, and\nscheduling schemes are discussed. A simulation evaluation of different\nLBT-based channel access procedures for NR-U/Wi-Fi indoor mmWave coexistence\nscenarios is also provided.\n
Optical beam splitter integrated on a magnetic atom chip (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Q. Diot, Y. Wang, D. Z. Anderson, E. A. Cornell, R. A. Saravanan, V. M. Bright, and M. Prentiss, "Optical Beam Splitter Integrated on a Magnetic Atom Chip," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference and Photonic Applications Systems Technologies, Technical Digest (CD) (Optica Publishing Group, 2004), paper IME1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Ignition Behavior of α-AlH3 (2010)

An experimental investigation on the ignition behavior of α-Aluminum Hydride (α-AlH3) has been conducted. The ignition characteristics were determined through the use of two separate modified T-jump experiments. In each experiment, a small amount of material was placed onto a platinum wire, which was heated rapidly through resistive heating. As a result both ignition and hydrogen release temperatures were studied for heating rates ranging from 104 to 105 K/s. The hydrogen release temperature was determined in vacuum, and ignition was studied at ambient pressure in air, CO2, and mixtures of argon with oxygen. Both the hydrogen release and ignition temperature increased as the heating rate increased. Hydrogen release temperatures ranged from approximately 650 to 1200 K, whereas ignition was observed to range from below the melting temperature of aluminum (933 K) to approximately 1500 K. Activation energies for hydrogen release were ∼27 kJ/mol, and are well below those reported by others at much lower heating rates. This result is consistent with the affects of higher heating rates transitioning the rate-limiting step from one of chemical kinetics to intraparticle hydrogen diffusion. For conditions in which the particles would ignite it was found that the environment did not play a significant role in the ignition temperature, beyond a critical oxygen mole fraction of XO2 > 0.05. Ensemble average burning times were found to decrease by a factor of about 3 when the oxygen mole fraction was increased from 0.1 to 0.5.
Phase II Trial of Oral Panobinostat (LBH589) in Patients with Refractory Cutaneous T-Cell Lymphoma (CTCL). (2008)

Abstract Background: Panobinostat is a histone deacetylase inhibitor that has shown promising results in cutaneous T-cell lymphoma (CTCL). Objectives: An open-label, multicenter, Phase II study is being conducted with a primary objective of establishing the efficacy and safety of the pan-deacetylase inhibitor, panobinostat (LBH589), for patients (pts) with relapsed/refractory CTCL with Stage IB–IVA mycosis fungoides (MF) or Sézary syndrome (SS). Methods: Inclusion criteria include adequate organ function, no clinically significant cardiovascular abnormalities (QTcF ≤ 450 ms, ECOG PS ≤2), failure of ≥2 prior systemic therapies, and no prior HDAC inhibitor treatment. Pts were grouped as having bexarotene therapy (Group [Gr] 1) or bexarotene naïve (Gr 2). Panobinostat was administered at a dose of 20 mg orally on Days 1, 3, 5, weekly, every 28 days until progression or unacceptable toxicity. Response was based on a composite score, including skin assessment with the modified Severity-Weighted Assessment Tool (mSWAT) and systemic disease assessed by CT scan. Results: To date, 95 pts (Gr 1=62; Gr 2=33) have enrolled with median age of 58 yrs [range 25–88]: 58 male, 37 female; 70 MF, 25 SS. Median prior treatment regimens are 4 and 3 for Gr 1 and 2, respectively. Most pts were ≥Stage IIB at study entry (Gr 1=42; Gr 2=26) and received 1–17+ (median=3) treatment cycles of panobinostat. In Gr 1, 11/62 pts have had confirmed skin responses by SWAT, including 2 complete skin responses. Confirmatory CT scans are pending for 2 patients. In Gr 2, 4/33 pts had confirmed skin and CT scan responses. Common AEs (&amp;gt;20%; all grades, regardless of causality) included diarrhea, thrombocytopenia, nausea, pruritus, fatigue, and asthenia, and Grade 3/4 AEs (&amp;gt;2%, regardless of causality) included thrombocytopenia, neutropenia, pruritus, diarrhea, and hypophosphatemia. Of 4,542 ECGs analyzed, 2 pts have had QTcF &amp;gt;480 ms; 4 had QTcF &amp;gt;60 ms increase from baseline. Conclusions: Panobinostat continues to demonstrate encouraging clinical activity with a manageable safety profile in pts with CTCL. Per predefined criteria, Group 2 enrollment to Stage 2 is open. Updated efficacy and safety data will be presented.
Template‐Controlled Reactivity in the Organic Solid State by Principles of Coordination‐Driven Self‐Assembly (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tunable plasmonic resonance arising from broken-symmetric silver nanobeads with dielectric cores (2012)

We investigate the plasmonic resonance modes and coupling effects of single silver nanobeads and silver nanobead dimers. Numerical investigation using the three-dimensional finite element method indicates that silver nanobeads exhibit two plasmonic resonances corresponding to the bonding and anti-bonding modes, respectively. The boundary symmetry on the inner and outer surfaces of the silver nanobeads can be broken by increasing the refractive indices of the cores filling the dielectric holes. It is shown that only the bonding mode can be found for low-refractive index cores, whereas both bonding and anti-bonding modes can be found for high-refractive index cores.
Haemophilus influenzae Surface Fibrils Contribute to Serum Resistance by Interacting with Vitronectin (2006)

Vitronectin inhibits the membrane attack complex of the complement system and is found both in plasma and the extracellular matrix. In this study, we have identified the outer membrane protein Haemophilus surface fibrils (Hsf) as the major vitronectin-binding protein in encapsulated H. influenzae type b. A H. influenzae mutant devoid of Hsf showed a significantly decreased binding to both soluble and immobilized vitronectin as compared with the wild-type counterpart. Moreover, Escherichia coli-expressing Hsf at the surface strongly adhered to immobilized vitronectin. Importantly, the H. influenzae Hsf mutant had a markedly reduced survival as compared with the wild-type bacterium when incubated with normal human serum. A series of truncated Hsf fragments were recombinantly manufactured in E. coli. The vitronectin binding regions were located within two separate binding domains. In conclusion, Hsf interacts with vitronectin and thereby inhibits the complement-mediated bactericidal activity, and thus is a major H. influenzae virulence factor.
Single Crystal of a Prussian Blue Analog based on Rubidium Manganese Hexacyanoferrate (2007)

Abstract A dark brown single crystal of rubidium manganese hexacyanoferrate, Rb 0.61 Mn[Fe(CN) 6 ] 0.87 ·1.7H 2 O, was obtained by the slow diffusion method. X‐ray single crystal analysis showed that this compound crystallized in the cubic system of space group $Fm{\bar 3}m$ with cell constants of a = b = c = 10.5354(4) Å, Z = 4, and R 1 = 0.0449. The CN groups bridge octahedral FeC 6 and MnN 0.87 O 0.13 . Rb and non‐coordinated water (so‐called zeolitic water) exist in the interstitial sites of the cubic lattice.
Low-Emissivity Metal/Dielectric Coatings as Radiative Barriers for the Fire Protection of Raw and Formulated Polymers (2020)

Radiative heat transfer dominates in medium- to large-scale fires, with infrared ray absorption causing the rapid ignition of combustible materials. In an attempt to hinder this phenomenon, low-emissivity coatings consisting of an aluminum layer topped by alumina have been deposited on polypropylene (PP) and polyamide 6 (PA6) substrates by pulsed DC magnetron sputtering. Emissivity measurements have confirmed the decrease in the emissivity of both surfaces. The samples were tested with a mass loss cone (MLC) calorimeter at 50 kW/m2 to mimic the radiative thermal constraint of the last stages of a developing fire. The evolution of the temperature was monitored by a thermocouple to confirm the radiative barrier effect. With this setup, it was evidenced that the presence of low-emissivity coatings reduced the heat absorption, effectively increasing the time to ignition of both substrates. Indeed, coated PP ignited after 7 min, whereas a neat PP ignited in 1 min, and PA6 had a time to ignition of as long as 1 h, as opposed to the neat polymer igniting in only 75 s. However, the effect of the coating on flammability parameters such as the peak heat release rate (PkHRR) and the total heat release (THR) was found to be very low. To counterbalance this downside and to take advantage of the reduction of heat absorption, Al/Al2O3 coatings were deposited on PP and PA6 filled with thermally triggered fire-retardant additives, respectively, expandable graphite and a commercial mixture of melamine polyphosphate and aluminum diethylphosphate. Without surface treatment, the presence of the additives caused a shorter time to ignition, but a reduction in the PkHRR of ∼50%. The combination of the Al/Al2O3 coating with flame retardants in the bulk led to both a long time to ignition and a reduction in the PkHRR and the THR under MLC testing.
ChemInform Abstract: DEOXYMORPHINES: ROLE OF THE PHENOLIC HYDROXYL IN ANTINOCICEPTION AND OPIATE RECEPTOR INTERACTIONS (1979)

Abstract Das Dihydromorphin (Ia) wird in das Tetrazolylderivat (Ib) umgewandelt, dessen Hydrierung in Essigsäure über Palladiumkohle zum Alkohol (IIa) führt.