gebhart/patrepeval huggingface dataset:
A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination (2015)

Abstract Invited for this months cover picture is the group of Professor Bernd Neumaier at the Institute of Radiochemistry and Experimental Molecular Imaging at the University Clinic of Cologne. The cover picture shows the differences in brain metabolism of a healthy young and a healthy old subject, as well as a patient suffering from Parkinsons disease (left to right) uncovered by 6‐[ 18 F]FDOPA‐positron emission tomography (PET). Morbus Parkinson occurs when nerve cells that produce dopamine begin to die. The shortage of dopamine leads to movement problems in affected individuals. 6‐[ 18 F]FDOPA is extensively used to evaluate the progression of Parkinsons disease. Bold stick projections of this PET tracer, as well as a neuronal network, are seen in the background. Unfortunately, conventional procedures to produce 6‐[ 18 F]FDOPA are cumbersome. Thus, several recent developments aim at the simplification of this radiosynthesis. In our work, we studied the applicability of the recently reported Ni‐mediated radiofluorination approach for daily routine production of 6‐[ 18 F]FDOPA. For more details, see the Full Paper on p. 457 ff.
Magnetic Field Probes for use in Radio Frequency Plasma (Preprint) (2009)

Abstract : An impedance analyzer has been used in the characterization of a magnetic induction probe (B-dot probe) for use in plasma. The role of the impedance analyzer was to determine the frequency response of a B-dot probe up to 100 MHz. The probe was specifically designed to take measurements in RF plasma driven at 13.56 MHz. Probe sensitivity and calibration are considered based on the impedance values obtained when a B-dot probe is swept over a wide frequency range. Effects such as unbalanced loads based on transmission line inductances and termination impedance are shown to be limiting factors on the probes useful frequency range.
Demodulation of extrinsic Fabry-Pe´rot interferometric sensors for vibration testing using neural networks (2004)

Strain level measurement on a periodically actuated and instrumented structure can provide information about the health of that structure. A simple demodulation system employing artificial neural networks (ANNs) is analyzed for an extrinsic Fabry-Pérot interferometric (EFPI) strain sensor. The harmonic content of the nonlinear sensor output for the sinusoidal strain case is used to predict the maximum strain level. Implementations of the demodulation system are demonstrated for both simulated and experimental data using back-propagation neural networks. The simulation uses the theoretical response of the EFPI sensor and the experiment uses an EFPI-instrumented smart composite beam to obtain training and testing data. Excitation is provided by a piezoelectric actuator operating from 50 Hz to 1 kHz. System performance is compared for two-stage and single-stage networks and for differing types of data preprocessing. The ANN systems successfully extract the signal harmonics and predict the peak strain levels. Data preprocessing using principal component analysis produces the best accuracy. The architecture of an EFPI-based health monitoring system is proposed.
400 Gbps Real-Time Coherent Nyquist-WDM DP-16QAM Transmission over Legacy G.652 or G.655 Fibre Infrastructure with 2 dB Margins (2015)

We experimentally demonstrate uncompensated error-free transmission of 400 Gbps real-time coherent DP-16QAM with Nyquist filtering (5.33 bit/s/Hz) over 500 km (resp. 300 km) of G.652 (resp. G.655) fibre using purely EDFA amplification and taking into account 2 dB margins.
Modified Nucleosides in the First Positions of the Anticodons of tRNA and tRNA from Escherichia coli (1998)

Minor leucine tRNA species, tRNA(Leu)4 and tRNA(Leu)5, from Escherichia coli B have been reported to recognize leucine codons UUA and UUG [Goldman, E., Holmes, W. M., and Hatfield, G. W. (1979) J. Mol. Biol. 129, 567-585]. In the present study, these two tRNA(Leu) species were purified from E. coli A19, and the nucleotide sequences were determined by a post-labeling method. tRNA(Leu)5 was found to correspond to the tRNA gene reported as su degrees6 tRNA [Yoshimura, M., Inokuchi, H., and Ozeki, H. (1984) J. Mol. Biol. 177, 627-644]. The first letter of the anticodon was identified to be 2'-O-methylcytidine (Cm). tRNA(Leu)4 was identified as the minor leucine tRNA that has been sequenced previously (tRNA(Leu)UUR) [Yamaizumi, Z., Kuchino, Y., Harada, F., Nishimura, S., and McCloskey, J. A. (1980) J. Biol. Chem. 255, 2220-2225]. There was an unidentified modified nucleoside (N*) in the first position of the anticodon of tRNA(Leu)4. Nucleoside N* was isolated to homogeneity (1 A260 unit). By 1H NMR spectroscopy, nucleoside N was found to be a 2'-O-methyluridine derivative with a substituent having a -CH2NH2+CH2COO- moiety in position 5 of the uracil ring. On the basis of these NMR analyses together with mass spectrometry, the chemical structure of nucleoside N* was determined as 5-carboxymethylaminomethyl-2'-O-methyluridine (cmnm5Um). Nucleoside N* was thus found to be a novel type of naturally occurring modified uridine. Because of the conformational rigidity of Cm and cmnm5Um in the first position of the anticodon, these tRNA(Leu) species recognize the leucine codons UUA++ and UUG correctly, but never recognize the phenylalanine codons UUU and UUC.
Privacy Preserving AKMA in 5G (2019)

3GPP is currently studying AKMA (Authentication and Key Agreement for Applications): a mobile network service intended to support authentication and key management based on 3GPP credentials in 5G system, for third-party applications and 3GPP services. AKMA extends and evolves two earlier services that 3GPP specified for previous generations of mobile systems. Those are GBA (Generic Bootstrapping Architecture) and BEST (Battery Efficient Security for very low Throughput Machine Type Communication (MTC) devices), In this paper, we have first analyzed potential AKMA requirements in the 3GPP study of AKMA vs. GBA and BEST. We have identified two new privacy requirements that could be useful to protect the privacy of user transactions with AKMA application function against, e.g., an insider attacker in the home network of that user. Second, we have developed a privacy-mode for AKMA that fulfills those new requirements.
Real-Time Transport Protocol (RTP) Payload Format for the Variable-Rate Multimode Wideband (VMR-WB) Extension Audio Codec (2006)

This document is an addendum to RFC 4348, which specifies the RTP
payload format for the Variable-Rate Multimode Wideband (VMR-WB)
speech codec. This document specifies some updates in RFC 4348 to
enable support for the new operating mode of VMR-WB standard (i.e.,
VMR-WB mode 4). These updates do not affect the existing modes of VMR-
WB already specified in RFC 4348. The payload formats and their
associated parameters, as well as all provisions, restrictions, use
cases, features, etc., that are specified in RFC 4348 are applicable
to the new operating mode with no exception. [STANDARDS-TRACK]
Direct Diode Pumped Kerr Lens Modelocked Ti:Sapphire Laser Oscillator (2012)

We describe a Ti:sapphire laser pumped directly with 445nm laser diodes. With 44 mW average power at 800 nm and bandwidth for &lt;50 fs pulses, Kerr-lens-modelocked pulses are available with dramatically decreased pump cost.
Glycopeptide alterations induced by 12-O-tetradecanoyl phorbol-13-acetate in chick embryo cultured myotubes (1982)

The tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) specifically inhibits the expression of differentiative traits in cultured chick embryo myotubes, without inducing them to reenter the cell cycle. We evaluated the effect of TPA on glycoconjugate synthesis in cultured myotubes under various experimental conditions. Radioactively labelled glycoconjugates were obtained by labelling control and TPA treated cultured myotubes with radioactive monosaccharides. After chloroform-methanol extraction and extensive pronase digestion, the glycoconjugates were separated on the basis of size on Sephadex G 50 columns. A relative enrichment in larger glycopeptides was induced by TPA treatment of myotubes for 24 or 48 h. Glycopeptide groups were further analyzed by affinity chromatography on ConA Sepharose columns. A marked and reproducible decrease in the affinity of medium size glycopeptides for ConA was observed as a result of TPA treatment of cultured myotubes. These modifications are reversible upon removal of the tumor promoter from the culture medium of pretreated myotubes. The reported effects of TPA, closely resembling those occurring in transformed cells, appear to be due to structural modifications of glycopeptides whose mechanism and role in transformation and modulation of differentiation are discussed.
100km Optical Chirp Chain BOTDA with Spatial Resolution of 4m (2022)

We proposed OCC-BOTDA using pattern recognition algorithm and differential pulse-width pair technique, which can improve the spatial resolution and sensing range effectively. A spatial resolution of 4m is achieved with a fiber length of 100km.
Protocol to isolate and assess spike protein cleavage in SARS-CoV-2 variants obtained from clinical COVID-19 samples (2022)

For efficient cell entry, SARS-CoV-2 spike protein needs to be cleaved by cellular proteases. Here, we present a comprehensive protocol to assess SARS-CoV-2 spike protein cleavage in viral supernatants from SARS-CoV-2-infected cells. We also include a previous step of SARS-CoV-2 isolation from nasopharyngeal swabs of patients with COVID-19. We optimized the procedures to enhance successful viral isolation and specific spike detection. This protocol facilitates the evaluation of the role of spike mutations in spike protein processing. For complete details on the use and execution of this protocol, please refer to Escalera et al. (2022).
Immunomodulation de la pancreatite experimentale (2003)

Doctorat en sciences médicales
Studies of the IF visible region chemical gasdynamic laser possibilities (1992)

A prospective candidate for chemical laser action in the visible region is the IF molecule, mainly because of its extremely high stimulated emission cross-section, which equals 10-15 cm2. In accordance with theory chemically induced lasing on the IF B→X transition (λ = 635 nm) may be effectively realized, if chemical reactions do proceed in the supersonic expanding high-enthalpy flow of the laser mixture.1,2
High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis (2010)

The magnitude of T2 signal intensity reduction in high-resolution MRI after administration of superparamagnetic phagocytosable nanoparticles can assess macrophage burden in atheromata, providing a clinically translatable tool to identify inflamed plaques and to monitor therapy-mediated changes in plaque inflammation.
N-octanoyl Dopamine Attenuates the Development of Transplant Vasculopathy in Rat Aortic Allografts Via Smooth Muscle Cell Protective Mechanisms (2015)

This study identified NOD as potential treatment modality to attenuate TV. Our data clearly support a vasculoprotective effect of NOD by reducing smooth muscle cell proliferation and inflammation-induced apoptosis.
Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application (2015)

The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA). We use Argan oil as vehicle of hydrophobic drugs such as indomethacin. Nanoprecipitation technique was used like a method for preparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively. Primarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was done. Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were characterized by studying particles size, zeta potential, and encapsulation efficiency. It is shown that particle size ranged between 290 nm and 350 nm. The zeta potential values were negative (from −40 up to −50 mV) while encapsulation efficiency ranged between 65 and 75%.
Quality & Generality: A Flexible FPGA Re-Clustering Technique to Improve Packing and Placement (2022)

The Packing and Placement stages are two major steps in the FPGA backend flow which greatly affect the Quality-of-Results (QoR) of design implementation. While these problems have been extensively studied in the literature, most approaches have either sacrificed generality by targeting specific and simplified FPGAs with few “block packing” legality constraints, or sacrificed quality by making irreversible packing decisions early in the flow and hence constraining the optimizations available to the subsequent placement stage. In this paper, we propose a new (re-clustering API) that can be used to update the packed netlist at different points throughout the packing and placement stages. This API can be used in our proposed flow to improve the QoR while preserving the generality and flexibility of the flow and ensuring the legality of the solution for any proposed FPGA architecture.
Controlling DNA–nanoparticle serum interactions (2016)

Understanding the interaction of molecularly assembled nanoparticles with physiological fluids is critical to their use for in vivo delivery of drugs and contrast agents. Here, we systematically investigated the factors and mechanisms that govern the degradation of DNA on the nanoparticle surface in serum. We discovered that a higher DNA density, shorter oligonucleotides, and thicker PEG layer increased protection of DNA against serum degradation. Oligonucleotides on the surface of nanoparticles were highly resistant to DNase I endonucleases, and degradation was carried out exclusively by protein-mediated exonuclease cleavage and full-strand desorption. These results enabled the programming of the degradation rates of the DNA-assembled nanoparticle system from 0.1 to 0.7 h<sup>-1</sup> and the engineering of superstructures that can release two different preloaded dye molecules with distinct kinetics and half-lives ranging from 3.3 to 9.8 h. This study provides a general framework for investigating the serum stability of DNA-containing nanostructures. The results advance our understanding of engineering principles for designing nanoparticle assemblies with controlled in vivo behavior and present a strategy for storage and multistage release of drugs and contrast agents that can facilitate the diagnosis and treatment of cancer and other diseases.
Simultaneous measurement of phase retardation and optic axis of a phase compensation film using an axially-symmetric sheared polymer network liquid crystal (2005)

A new method for simultaneously measuring the phase retardation and optic axis of a uniaxial compensation film is demonstrated using an axially-symmetric sheared polymer network liquid crystal (SPNLC). By overlaying a tested compensation film with a calibrated SPNLC cell between crossed polarizers, two dark spots are clearly observed in a CCD image. From the orientation direction and distance of these two spots, the optic axis and phase retardation value of the compensation film can be determined. This method is particularly useful for those optical systems whose optic axis and phase retardation are dynamically changing.
Multispectral Image Compression for High Fidelity Colorimetric and Spectral Reproduction (2006)

The article aims to provide a solution for multispectral image compression for high color reproducibility with preservation to spectral accuracy. In the method previously proposed to reduce the colorimetric error of the reconstructed multispectral image, a weighting matrix is incorporated to Karhunen-Loeve transform (KLT) as the spectral transform for multispectral image compression, which accounts for the color matching functions of human observers as well as the viewing illuminants. However, the colorimetric improvements are obtained on the cost of degradation of spectral accuracy. In this paper, we show that the reduction of colorimetric error and the preservation of spectral accuracy is a tradeoff that can be controlled by adding a diagonal matrix that is composed of a scalar multiple of an identity matrix to the weighting matrix of KLT. As the result, the small values in the weighting matrix can be lifted up, thus reduce the spectral errors in the corresponding reconstructed multispectral image bands. We implement a multispectral image compression system that integrates the proposed spectral transforms with the addition of diagonal matrix and JPEG2000 for high colorimetric and spectral reproducibility. Experimental results for three 16-band multispectral images show that spectral accuracy can be improved without loss of substantial color reproducibility if the magnitude of the scalar in the diagonal matrix is chosen appropriately
High-speed, high-frequency ultrasound, in utero vector-flow imaging of mouse embryos (2017)

Real-time imaging of the embryonic murine cardiovascular system is challenging due to the small size of the mouse embryo and rapid heart rate. High-frequency, linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and Doppler modes but are limited in regards to the field of view that can be imaged at fine-temporal and -spatial resolution. Here, a plane-wave imaging method was used to obtain high-speed image data from in utero mouse embryos and multi-angle, vector-flow algorithms were applied to the data to provide information on blood flow patterns in major organs. An 18-MHz linear array was used to acquire plane-wave data at absolute frame rates ≥10 kHz using a set of fixed transmission angles. After beamforming, vector-flow processing and image compounding, effective frame rates were on the order of 2 kHz. Data were acquired from the embryonic liver, heart and umbilical cord. Vector-flow results clearly revealed the complex nature of blood-flow patterns in the embryo with fine-temporal and -spatial resolution.
On Exact Computation with an Infinitely Wide Neural Net (2019)

How well does a classic deep net architecture like AlexNet or VGG19 classify on a standard dataset such as CIFAR-10 when its width --- namely, number of channels in convolutional layers, and number of nodes in fully-connected internal layers --- is allowed to increase to infinity? Such questions have come to the forefront in the quest to theoretically understand deep learning and its mysteries about optimization and generalization. They also connect deep learning to notions such as Gaussian processes and kernels. A recent paper [Jacot et al., 2018] introduced the Neural Tangent Kernel (NTK) which captures the behavior of fully-connected deep nets in the infinite width limit trained by gradient descent; this object was implicit in some other recent papers. An attraction of such ideas is that a pure kernel-based method is used to capture the power of a fully-trained deep net of infinite width. The current paper gives the first efficient exact algorithm for computing the extension of NTK to convolutional neural nets, which we call Convolutional NTK (CNTK), as well as an efficient GPU implementation of this algorithm. This results in a significant new benchmark for the performance of a pure kernel-based method on CIFAR-10, being $10\%$ higher than the methods reported in [Novak et al., 2019], and only $6\%$ lower than the performance of the corresponding finite deep net architecture (once batch normalization, etc. are turned off). Theoretically, we also give the first non-asymptotic proof showing that a fully-trained sufficiently wide net is indeed equivalent to the kernel regression predictor using NTK.
Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer (2017)

<i>CDK4/6</i>-mediated resistance observed in preclinical experiments suggests that <i>CDK4/6</i> amplifications may sufficiently promote enzalutamide resistance in CRPC, and that these patients may respond to palbociclib or ribociclib. The overall observations suggest that, in genomically selected advanced CRPC, clinical strategies against abiraterone- or enzalutamide-resistant tumors may require treatment strategies that are tailored to the resistance mechanisms that are specific to those patient subpopulations.
Three-Dimensional Coordinate Data Processing in Human Motion Analysis (1979)

A method for three-dimensional coordinate processing of human motion is presented. The method is well suited for use with opto-electronic data acquisition equipment. A resolution of one part in 500 was achieved over a viewing field of 2.4 m. This resolution was found to be adequate for human gait analysis studies.
Supplementary Movie 2 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression (2023)

&lt;p&gt;Isotype control&lt;/p&gt;
13.3‐inch 8k4k 664‐ppi foldable OLED display using crystalline oxide semiconductor FETs (2015)

Abstract A prototype 13.3‐inch 8k4k 664‐ppi high‐resolution foldable organic light emitting diode display is constructed. C‐axis aligned a‐b‐plane‐anchored crystal In–Ga–Zn oxide field effect transistors designed using a 1.5‐µm rule process are used in the backplane. Each pixel circuit has three transistors and one capacitor, and an external circuit is used to correct pixel current.
Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites (2016)

Immunization strategies that generate either CD4 or CD8 T cell responses are relatively well described, but less is known with regard to optimizing regimens to induce both CD4 and CD8 memory T cells. Considering the importance of both CD4 and CD8 T cells in the control of intracellular pathogens such as Leishmania donovani, we wanted to identify vaccines that could raise both CD4 and CD8 T cell responses and determine how to configure immunization strategies to generate the best combined protective T cell response. We examined responses generated against the Leishmania vaccine antigen F3 following its administration in either recombinant form with the Toll-like receptor 4 (TLR4) agonist-containing adjuvant formulation GLA-SE (F3+GLA-SE) or as a gene product delivered in an adenoviral vector (Ad5-F3). Homologous immunization strategies using only F3+GLA-SE or Ad5-F3 preferentially generated either CD4 or CD8 T cells, respectively. In contrast, heterologous strategies generated both antigen-specific CD4 and CD8 T cells. Administration of F3+GLA-SE before Ad5-F3 generated the greatest combined CD4 and CD8 responses. Cytotoxic CD8 T cell responses were highest when Th1 cells were generated prior to their induction by Ad5-F3. Finally, a single immunization with a combination of F3+GLA-SE mixed with Ad5-F3 was found to be sufficient to provide protection against experimental L. donovani infection. Taken together, our data delineate immunization regimens that induce antigen-specific CD4 and CD8 T cell memory responses, and identify a single immunization strategy that could be used to rapidly provide protection against intracellular pathogens in regions where access to health care is limited or sporadic.