gebhart/patrepeval huggingface dataset:
Dynamic crystallization behavior, morphology, and physical properties of highly concentrated poly(vinylidene fluoride)/silver nanocomposites (2010)

Abstract The effects of the inclusion of silver (Ag) nanoparticles on the physical properties, the crystallization behavior under shear, and the consequential crystalline morphology of poly(vinylidene fluoride) (PVDF) were investigated. Ag nanoparticles were melt compounded with PVDF in weight fractions of 20, 50, and 90 wt % (15.3 vol %). In the melt rheology, the presence of 20 wt % Ag nanoparticles had little effect on the dynamic viscosity of PVDF, but further addition increased it with the loading level. In Cole–Cole plot, all the melts gave a single master curve independent of the presence of Ag nanoparticles. As Ag loading level was increased, the overall crystallization process under shear was accelerated by reducing both induction time and crystallization time. The degree of acceleration was more notable at higher crystallization temperatures. The induction time and the crystallization time of 90 wt % loaded nanocomposites were promoted by 53.5 and 3.7%, respectively, at 145 °C and by 62 and 26.3%, respectively, at 160 °C, compared with those of pure PVDF. For the isothermal crystallization measured by differential scanning calorimeter, the critical Ag concentration, where overall crystallization was not promoted by further addition, occurred between 50 and 90 wt %. Both wide angle X‐ray diffraction profiles and Fourier transform infrared spectra of the samples crystallized under shear displayed the peaks for only α‐form crystals without new peak or peak shift regardless of the Ag loading and crystallization temperature. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2010
Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases (2008)

Cyclin dependent kinase 4 is a key regulator of the cell cycle and its activity is frequently deregulated in cancer. The activity of cyclin dependent kinase 4 is controlled by multiple mechanisms, including phosphorylation of tyrosine 17. This site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory phosphorylation by WEE1 and MYT1; however, the kinases that phosphorylate cyclin dependent kinase 4 on tyrosine 17 are still unknown. In the present study, we generated a phosphospecific antibody to the tyrosine 17-phosphorylated form of cyclin dependent kinase 4, and showed that this site is phosphorylated to a low level in asynchronously proliferating HCT116 cells. We purified tyrosine 17 kinases from HeLa cells and found that the Src family non-receptor tyrosine kinase C-YES contributes a large fraction of the tyrosine 17 kinase activity in HeLa lysates. C-YES also phosphorylated cyclin dependent kinase 4 when transfected into HCT116 cells, and treatment of cells with Src family kinase inhibitors blocked the tyrosine 17 phosphorylation of cyclin dependent kinase 4. Taken together, the results obtained in the present study provide the first evidence that Src family kinases, but not WEE1 or MYT1, phosphorylate cyclin dependent kinase 4 on tyrosine 17, and help to resolve how the phosphorylation of this site is regulated.
First Observation of the DecayBs2*(5840)0→B*+K−and Studies of ExcitedBs0Mesons (2013)

The properties of the orbitally excited (L=1) Bs(0) states are studied by using 1.0 fb(-1) of pp collisions at sqrt[s]=7 TeV collected with the LHCb detector. The first observation of the Bs2*(5840)(0) meson decaying to B*+ K- is reported, and the corresponding branching fraction measured relative to the B+ K- decay mode. The Bs1(5830)(0)→B*+ K- decay is observed as well. The width of the Bs2*(5840)(0) state is measured for the first time, and the masses of the two states are determined with the highest precision to date. The observation of the Bs2*(5840)(0)→B*+ K- decay favors the spin-parity assignment J(P)=2+ for the Bs2*(5840)(0) meson. In addition, the most precise measurement of the mass difference m(B*+)-m(B+)=45.01±0.30(stat)±0.23(syst) MeV/c(2) is obtained.
P3‐280: Characterization of TAT‐conjugated B6‐C15 peptide which is a common mimotope of Aß42‐fibril‐specific human scFvs in a flow of Aß42 fibrillation (2010)

Aggregation and fibril formation of amyloid-ß42 (Aß42) peptides is crucial events in the phathogenesis of Alzheimer's disease. Recently, we have established conformation dependent human antibody, B6, which binds to Aß42 fibril, but not to soluble form of Aß42, inhibiting Aß42 fibril formation. We have identified a mimotope of B6, B6-C15, using the random peptide displaying phage library (PhD.C7C). We synthesized B6-C15 peptide conjugated with biotinylated TAT at the N-terminus (TAT-B6-C15). It was demonstrated that this peptide inhibited Aß42 fibrillation by binding to prefibrillar oligomer, but not to freshly prepared monomer Aß42 nor its fibril form. In this study, we investigated the molecular mechanism of Aß42 fibril formation by using of TAT-B6-C15 peptide. Aß42 fibrillation was tested by mixing various Aß42 confromers as a seed and either monomer Aß42, prefibrillar oligomer or fragmented fibril in the presence or absence of TAT-B6-C15. The fibrillation was observed by transmission electron microscopy or amyloid specific fluorescence dye, Thioflavin T. Prefibrillar oligomer was generated in 1.5 hr by Aß42 assembly reaction. This fraction contained SDS-sensitive as well as SDS-resistant oligomers. When the prefibrillar oligomer was purified by Superdex 75, this fraction did not precede Aß42 fibrillation. This result suggests that firstly, prefibrillar oligomer do not easily dissociate to monomer Aß42, secondly that prefibrillar oligomer formation is a distinct pathway from Aß42 fibrillation. Furthermore, when sonicated fibrils were mixed with prefibrillar oligomer, Aß42 fibril was generated. In contrast, sonicated fibrils do not assemble each other to Aß42 fibril. This result indicated that prefibrillar oligomer was able to assemble to sonicated fibril as a seed, suggesting that there are two distinct elongation pathway for Aß42 fibrillation, i.e., by either a simple linear polymerization mechanism of monomer Aß42 or by attaching prefibrillar oligomer to short fibril (corresponding to fragmented fibril). Thus, TAT-B6-C15 inhibits Aß42 fibrillation by binding to prefibrillar oligomer.
Pigs experimentally infected withSerpulina hyodysenteriaecan be protected from developing swine dysentery by feeding them a highly digestible diet (1996)

Weaner pigs (n = 72) were fed 1 of 4 diets. These were based on either cooked rice and animal protein, cooked rice and lupin, wheat and lupin, or wheat and animal protein. Twenty-six of the pigs were slaughtered after 1 month. Those fed the highly digestible cooked rice and animal protein diet had drier colonic contents and faeces, lighter large intestines, and the contents of their large intestines had increased pH values and decreased total VFA concentrations. The other 46 were orally challenged with broth cultures of Serpulina hyodysenteriae, and were monitored for faecal excretion of the spirochaetes, and for the development of swine dysentery (SD). None of 18 pigs fed the cooked rice and animal protein diet developed colonic changes or disease, whereas most pigs on the other diets developed mucohaemorrhagic colitis and dysentery. The reduced fermentation that occurred in the large intestines of pigs fed cooked rice and animal protein was associated with a subsequent failure of colonization by S. hyodysenteriae, and resultant protection against SD.
Numerical measures of two‐dimensional gel resolution and positional reproducibility (1983)

Abstract Procedures to measure two important properties of two‐dimensional electrophoresis systems have been developed. These procedures evaluate the overall resolution and positional reproducibility of two‐dimensional gel patterns. Using these measures we show that various state of the art gel systems can produce patterns exhibiting resolution measures of 15 000–50 000 (yielding practical upper bounds of about 2000–6000 detectable proteins in typical cellular samples) and that positional accuracy for most spots in gel‐to‐gel comparisons is better than a spot width (0.5–2.0 mm). Implemented as part of a computerized image analysis system for two‐dimensional gel data, these two measures can be used in the selection and optimization of gel systems, and in the selection of sets of well‐resolved, well‐matched spots for genetic and other quantitative sudies.
Excimer lasers for micromachining (1994)

The authors discuss the problem of the design of the optical beam delivery system in excimer laser micromachining. The authors' solutions are described and examples of machining structures and shaped holes, for a large variety of products, are presented. >
Development of a Mobile Platform for Wheat Phenotyping (2020)

Abstract Designing and implementing an affordable High-Throughput Phenotyping Platform (HTPP) for monitoring crops’ features in different stages of their growth can provide valuable information for crop-breeders to study possible correlation between genotypes and phenotypes. Conducting automatic field measurements can improve crop productions. In this research, we have focused on development of a mechatronic system, hardware and software, for a mobile field-based HTPP for autonomous crop monitoring for wheat field. The system can measure canopy’s height, temperature, vegetation indices and is able to take high quality photos of crops. The system includes developed software for data and image acquisition. The main contribution of this study is autonomous, reliable, and fast data collection for wheat and similar crops.
Expression of cytoskeletal protein 4.1 during avian erythroid cellular maturation. (1987)

We have isolated a cDNA clone encoding part of protein 4.1, an integral component of the erythrocyte cytoskeleton. The recombinant was isolated by immunological screening of a chicken erythroid lambda gt11 cDNA library using a monoclonal antibody directed against protein 4.1. DNA blot analysis shows that the gene is present as a single copy per haploid chicken genome, while RNA blot analysis reveals the presence of a single mRNA of 7 kilobases in reticulocytes. Message of the same size (in reduced amounts) is also present in an erythroleukemic cell line transformed by avian erythroblastosis virus and is also present in vastly reduced quantities in nonerythroid hemopoietic cells. Immunoblotting and immunofluorescence experiments show that a subset of the chicken 4.1 variant proteins is preferentially expressed during in vitro differentiation of chicken erythroleukemic cells. These data indicate that the gene is both actively transcribed and translated during early erythroid cellular maturation.
Amino acid sequence of an immunoglobulin-like HLA antigen heavy chain domain. (1979)

The classical human transplantation antigens, derived from the HLA-A, -B, and -C loci, are cell-surface-expressed glycoproteins. On the exterior of the cell the transplantation antigen heavy chain exposes two disulfide-containing domains and a glycosylated NH2-terminal extension. The disulfide-containing domain closest to the membrane has been isolated and its amino acid sequence has been determined. The HLA antigens used for the sequence analysis were derived from two and possibly three loci and comprised several allelic forms. The primary structure was remarkably invariant, and amino acid variations were observed only at three positions. Whether this suggests that the allelic variation of the HLA antigens is preferentially confined to other regions of the molecule or is a result of fortuitous selection of peptides remains to be established. The sequenced portion of the HLA antigen heavy chain is as homologous to beta 2-microglobulin and immunoglobulin light and heavy chains as are the latter to one another. This observation strengthens the notion that the transplantation antigens and the immunoglobulins are evolutionarily related.
ChemInform Abstract: NUCLEOPHILIC CHARACTER OF ACYL RADICALS. ABSOLUTE RATE CONSTANT FOR THE ACYLATION OF PROTONATED BENZOTHIAZOLE BY PIVALOYL RADICAL (1977)

Abstract Protoniertes Benzothiazol (I) reagiert mit Pivalinaldehyd (II), Fe(II)‐sulfat und tert.‐Butylhydroperoxid bei 5°C zu den Substitutionsprodukten (III) und (IV) mit einer Gesamtausbeute von 96%.
Measurement of the g-tensor of the P700+. signal from deuterated cyanobacterial photosystem I particles. (1993)

We report high-field continuous wave EPR spectra of P700+. in preparations obtained from deuterated cyanobacteria (Synechococcus lividus). Measurements were performed with photosystem I (PS-I) preparations, whole cells from cyanobacteria grown in 2H2O, and photosystem II (PS-II) preparations, as well as with protonated PS-I preparations. Because of the significantly improved resolution of our 140-GHz spectrometer (as compared with X- or Q-band EPR) the principal values of the g-tensor of the primary donor P700+. could be resolved and measured with high accuracy as g11 = 2.00304, g22 = 2.00262, and g33 = 2.00232. Other signals arising from Mn2+ and a dark signal from PS-II at g approximately 2.00266 are distinguished from the P700+. g-tensor powder pattern. The measured g values are compared with those of several bacterial reaction center donors.
Risk assessment of cable discharge events (2017)

A rigorous measurement set-up, parameter extraction procedure, and SPICE simulation approach are presented which allows to assess the risk of ESD events caused by plugging a charged cable to a port of an electronic system (Cable Discharge Events). The feasibility of the approach is demonstrated on different USB-3 cables.
A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data (2019)

Our proposed prediction model provides an effective tool for DLB classification. Also, a gene-based association test of rare variants revealed that BCL2L1 and PIK3R2 were statistically significantly associated with DLB.
Impact of mobility on cooperative communication (2006)

We investigate the performance degradation due to rapidly time varying channels in a repetition based coherent cooperative system. We demonstrate that mobility of source affects the performance much more than the mobility of destination, for both amplify and forward (AF) and demodulate and forward (DF) relays, despite the symmetry of the network. Exploiting the property of FSK modulation that allow us to detect either coherently or noncoherently or even semi-coherently, we develop ML detection rules for a variety of mobile scenarios. The detection rules that take into account the mobility of the nodes, are mostly hybrids of partially coherent detectors and noncoherent detectors. The performance of these detectors is better than the best of coherent and noncoherent detectors in fast fading and a gain of about 2 dB is obtained over a wide range of SNR and a gain of almost 3 dB is achieved at the crossing of coherent and noncoherent curves. As energy efficiency is one of the main objectives for pursuing cooperation and relaying, these hybrid detectors assume significance in fast fading scenarios
Signalling Unnumbered Links in CR-LDP (2000)

Verapamil was examined for its effect on the frequency of miniature end-plate potential (m.e.p.p.) in rat diaphragm muscles. Verapamil (5 x 10(-5) M) raised the m.e.p.p. frequency. This effect was reversible, reproducible, and concentration dependent. The rise in the frequency was maintained in the presence of external Ca++ but was transient in the absence of external Ca++. Lowering the temperature to 20 degrees C slightly decreased the average frequency of m.e.p.p. in the normal medium. The effect of verapamil was also present at a low temperature but was delayed in its onset. The resting membrane potential of the muscle fiber was not affected by the agent. These results suggest the possibility that verapamil increases the transmitter release from motor nerve terminals, and the effect is possibly due to a release of Ca++ for its initiation, but is dependent on external Ca++ for its maintenance.
157-nm resist assessment by a full-field scanner (2004)

Fluorinated polymers are key materials for single-layer resists used in 157-nm lithography. We have evaluated the potential of fluorinated polymer-based resists from the viewpoint of critical dimension (CD) control, using a 0.90 numerical aperture (NA) 157-nm micro-stepper with an alternating phase shift mask (alt-PSM). A resolution limit of 55-nm line-and-space patterns was obtained and the bake temperature dependence of the CD was found to be less than 2 nm/°C. We further evaluated these resists using a 0.80-NA FPA-5800FS1 157-nm scanner for full-field imaging with an alt-PSM. With these resists, 60-nm line-and-space patterns were resolved, and a depth of focus (DOF) of more than 400 nm for 100- and 80-nm line-and-space patterns was confirmed. The CD variation across the wafer for a 100-nm 1:1 dense line pattern was 3.3 nm (3σ). Although there is still a need to improve line edge roughness and dry etching resistance, in terms of CD control the fluorinated polymer-based resists have demonstrated sufficient potential for mass-production of 65-nm-node semiconductor devices and beyond.
Supplementary Figure 4 from Application of a Proapoptotic Peptide to Intratumorally Spreading Cancer Therapy (2023)

&lt;p&gt;PDF file - 4704K, Figure S4. Tumor volume and body weight of mice bearing orthotopic 4T1 tumors and treated with intravenously injected Bit1 cell death domain constructs.&lt;/p&gt;
Epoque: Practical End-to-End Verifiable Post-Quantum-Secure E-Voting (2021)

The ultimate goal in modern secure e-voting is to enable everyone to verify whether the final election result correctly reflects the votes chosen by the (human) voters, without exposing how each individual voted. These fundamental security properties are called end-to-end verifiability and voter privacy. Unfortunately, it turns out to be very challenging to pursue these properties simultaneously, especially when the latter must be future-proofed against the rise of quantum computers. In this work, we show, for the first time, a practical approach to do this. We present Epoque, the first end-to-end verifiable, voter-private, post-quantum-secure homomorphic e-voting protocol. It achieves its properties through the combination of practical lattice-based cryptographic primitives only, in a novel way. We formally prove all our security claims under common trust and hardness assumptions. At the core of Epoque lies an efficient identity-based encryption (IBE) scheme with blazingly fast master-key decryption. It is the component that makes the efficient tallying of thousands or millions of ballots a practical possibility. In order to demonstrate its practicality, we fully implemented it and provide detailed benchmarks; we believe this latter contribution is of independent interest beyond the specific e-voting application.
Algebraic Dynamic Multilevel Method for Compositional Simulations (2017)

Abstract A dynamic multilevel compositional solver (C-ADM) is introduced for fully(and sequentially-) implicit systems arising from compositional displacements in natural porous media. The fully (or sequential) implicit system is first described at a fine-scale resolution, where phases are allowed to consist of different components (based on thermodynamics equilibrium). In addition, heterogeneous capillary functions (defined based on Leverett's J-function) and gravitational effects are both considered, adding significantly to the non-linear complexity of the processes. Given this complex fine-scale system for a heterogeneous reservoir, C-ADM defines a dynamic multilevel system, based on an error criterion, where the grid resolution is defined based on the physics of the process as well as geological complexities and location of wells. Once this multilevel grid is defined, sequences of prolongation and restriction operators are employed to obtain an accurate and efficient multilevel system. CADM allows for a general set of prolongation operators, e.g., constant, bilinear (or polynomial), and multiscale basis functions. The restriction operators, however, are constructed based on a mass-conservative finite-volume formulation at all levels. For several challenging test cases it is shown that C-ADM employs only a small fraction of the fine-scale grids to provide an accurate description of the process. C-ADM casts a promising approach in the application of dynamic grid refinement methods for real-field applications.
Copper Solvent Extraction from Waste Cyanide Solution with LIX 7820 (2009)

The use of a solvent mixture of a quaternary amine and nonylphenol (LIX 7820) to extract copper cyanide from waste cyanide solution has been studied. Copper extraction is favorable at low pH, whereas a high cyanide‐to‐copper ratio tends to suppress copper loading. The preferential extraction of Cu(CN)3 2− over Cu(CN)4 3− and CN− has been confirmed by the examination of both the extraction of copper and cyanide by the solvent mixture under different experimental conditions. The solvent mixture also strongly extracted zinc and nickel from the cyanide solution, but it exhibits weak affinity for iron cyanide complex and free cyanide. The important findings suggested the potential application of the solvent mixture for the recovery of copper and cyanide from waste cyanide solutions, by which copper can be extracted and concentrated into a small volume of solution and the barren cyanide solution recycled to the cyanidation process.
Use of An Active Electro-Hydrostatic Actuation System for Vehicle Vibration Damping Applications (2013)

Conventional vibration damping in wheeled vehicles is mainly performed by means of passive hydraulic systems. Active and semi-active solutions are adopted when there is particular interest in varying the damping response of the shock absorbers for vehicle handling and comfort. To this end, electro-hydrostatic actuation (EHA) devices represent a promising alternative in active vibration control. In these systems, an electric motor is employed to drive a fixed-displacement hydraulic pump. The flow generated by the pump is then conduced into a hydraulic piston that acts as a conventional damper. The use of a motor as a primary actuation device eases the control task and offers a large output bandwidth. This feature represents an advantage with respect to active hydraulic technologies, which attain limited bandwidth frequencies and use highly nonlinear servo-valves. Moreover, the reversible nature of the electric machine in EHA actuators allows part of the energy exchanged during damping to be recovered. When compared to electromechanical shock absorbers, EHA devices offer higher output power densities and higher efficiencies. In this context, the present paper describes the design, modelling and control of an active EHA system utilized for vehicle damping purposes. An overview of the current active solutions and a comparison with the EHA technology are revised. Results in terms of damping response and energy harvesting capabilities are then discussed
Microscale Nonreductive Release of O-Linked Glycans for Subsequent Analysis through MALDI Mass Spectrometry and Capillary Electrophoresis (2001)

A new beta-elimination-based procedure has been devised for a microscale release of O-linked oligosaccharides from glycoproteins. Unlike the conventional Carlson degradation, which leads to formation of alditols, the procedure reported here renders the reducing end intact. Conversion of the liberated oligosaccharides to glycosylamines in ammonia medium is followed by the production of the reducing oligosaccharides through the addition of boric acid. The quantitatively generated oligosaccharides with the reducing end can subsequently be derivatized with a fluorophoric reagent for capillary electrophoresis or, alternatively, analyzed through MALDI mass spectrometry. The microscale version of these chemical steps permits us to investigate structurally O-linked oligosaccharides at very low levels.