gebhart/patrepeval huggingface dataset:
Optimizing the Dynamic Behavior of Wells and Facilities with Machine Learning and Agent Negotiation Techniques (2020)

Summary The paper proposes an approach to deal with the day by day dynamic behaviour of Oil &amp; Gas assets, providing support for optimized decisions on wells and facilities. The approach is based on: • A set of software agents, trained with a machine learning approach to understand the health status of the components of the reservoir/well/plant system and capable of proposing optimization actions for the corresponding subsystem; • An inter-agent negotiation approach, capable of evaluating the optimization actions of the single agents in the wider picture of the overall optimization of the producing asset. The paper will describe how this approach has been implemented, as well as an example application.
Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1. (1996)

The enediyne anti-tumour antibiotics are extremely potent cytotoxins, apparently because of their conversion to diradical species which induce DNA double strand breaks with high efficiency. The potency of enediynes suggests their possible utility as effector units for prodrugs which can be activated selectively in tumours, such as bioreductive drugs (BD) or radiation-activated cytotoxins (RAC). However, the similarity of the radical-induced DNA breakage reactions of the enediynes to those caused by ionising radiation suggested that resistance of hypoxic cells might be a potential problem. Experiments with AA8 cells in culture demonstrated that the enediyne antibiotics neocarzinostatin and esperamicin A, (ESP) are much less toxic under hypoxic than aerobic conditions. Sensitivity to ESP (concentration for 90% cell kill 10 pM) decreased 15-fold under hypoxia, and was partially restored by simultaneous exposure to misonidazole. ESP induced chromosome breakage (micronucleus formation) with an efficiency similar to gamma radiation at equivalent cell kill, suggesting a clastogenic mechanism of cytotoxicity. In contrast, little micronucleus formation was evident after exposure to ESP under hypoxia, even at concentrations giving equivalent cell killing. These findings suggest that resistance of hypoxic cells may limit the utility of enediynes as cytotoxic effectors for BD or RAC prodrug development, and that further investigation of enediynes as anti-tumour agents should include strategies capable of eliminating hypoxic cells.
Figure S5 from The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia (2023)

&lt;p&gt;Figure S5. Daratumumab activity in a CLL-PDX model.&lt;/p&gt;
Cutting Edge: CD1a Tetramers and Dextramers Identify Human Lipopeptide–Specific T Cells Ex Vivo (2013)

Human CD1a mediates foreign Ag recognition by a T cell clone, but the nature of possible TCR interactions with CD1a/lipid are unknown. After incubating CD1a with a mycobacterial lipopeptide Ag, dideoxymycobactin (DDM), we identified and measured binding to a recombinant TCR (TRAV3/ TRBV3-1, KD of ≈100 μM). Detection of ternary CD1a/lipid/TCR interactions enabled development of CD1a tetramers and CD1a multimers with carbohydrate backbones (dextramers), which specifically stained T cells using a mechanism that was dependent on the precise stereochemistry of the peptide backbone and was blocked with a soluble TCR. Furthermore, sorting of human T cells from unrelated tuberculosis patients for bright DDM-dextramer staining allowed recovery of T cells that were activated by CD1a and DDM. These studies demonstrate that the mechanism of T cell activation by lipopeptides occurs via ternary interactions of CD1a/Ag/TCR. Furthermore, these studies demonstrate the existence of lipopeptide-specific T cells in humans ex vivo.
Antibody action after phagocytosis promotesCryptococcus neoformansandCryptococcus gattiimacrophage exocytosis with biofilm-like microcolony formation (2008)

Antibody-mediated phagocytosis was discovered over a century ago but little is known about antibody effects in phagolysosomes. We explored the consequences of antibody-mediated phagocytosis for two closely related human pathogenic fungal species, Cryptococcus neoformans and Cryptococcus gattii, of which C. neoformans encompasses two varieties: neoformans and grubii. The interaction between C. neoformans varieties grubii and neoformans and host cells has been extensively studied, but that of C. gattii and macrophages remains largely unexplored. Like C. neoformans, antibody-mediated phagocytosis of C. gattii cells was followed by intracellular replication, host cell cytoplasmic polysaccharide accumulation and phagosomal extrusion. Both C. gattii and C. neoformans cells exited macrophages in biofilm-like microcolonies where the yeast cells were aggregated in a polysaccharide matrix that contained bound antibody. In contrast, complement-opsonized C. neoformans variety grubii cells were released from macrophages dispersed as individual cells. Hence, both antibody- and complement-mediated phagocytosis resulted in intracellular replication but the mode of opsonization affected the outcome of exocytosis. The biofilm-like microcolony exit strategy of C. neoformans and C. gattii following antibody opsonization reduced fungal cell dispersion. This finding suggests that antibody agglutination effects persist in the phagosome to entangle nascent daughter cells and this phenomenon may contribute to antibody-mediated protection.
New advanced BARC materials for ultra-high NA applications (2005)

The 65nm half pitch node will require 193nm wavelength in combination with NA > 0.9 to keep k1 above 0.3. With such high angles of diffracted light the relative amount of TE (or s) polarization that contributes to image formation increases. Unfortunately, the swing curve for TE polarization is higher than normal for traditional BARC materials. This study explores new advanced bottom anti-reflective coating (BARC) materials dedicated to ultra-high NA imaging. The improvements in imaging performance over traditional BARCs are shown through simulations and experimental results with the latest high NA TWINSCAN XT:1400 exposure systems. Simulations will show the relation between various BARC and top anti-reflective coating (TARC) material approaches and high NA imaging performance. This was done, among other things, as function of illumination settings. These simulations are accompanied by experimental results with the different suggested BARC strategies as multi-layer BARCs and tunable reflective index materials. Initial experiments were done on the TWINSCAN XT:1250 with 0.85NA. After analyzing these results, further tests were done on the TWINSCAN XT:1400 NA=0.93 exposure system. These results verify the feasibility of the newly developed BARC materials.
Design of a minimum weight dual active bridge converter for an Airborne Wind Turbine system (2012)

The design procedure for a bidirectional DAB dc-dc converter, which provides a high dc voltage of 8kV to the tether of a 100 kW Airborne Wind Turbine (AWT) system, is presented. The maximum allowed weight of the dc-dc converter is 25 kg and, thus, the main challenge is the realization of a light-weight DAB converter. The investigated dc-dc converter is split up into 16 single DAB modules with a rated power of 6.25 kW and a dc port voltage of 2kV. Thus, a weight of less than 25 kg/16 = 1.56 kg needs to be achieved for a single DAB module. The design method used to obtain the minimum weight DAB converter, based on the evaluation of a power-to-weight ratio versus efficiency Pareto Front (γ-η-Pareto Front) is presented in this paper. For this purpose the transient voltages and currents of the employed SiC JFETs during switching are discussed in detail, since the respective measurement results allow for a prediction of the switching losses. Moreover, the calculated transformer is realized and experimental results are used to verify the weight, the losses, and the cooling system performance of the transformer. For a single DAB module a weight of m = 1.43 kg, an efficiency of η = 97%, and a power-to-weight ratio of γ = 4.4kW/kg results.
Cellular Microcultures: Programming Mechanical and Physicochemical Properties of 3D Hydrogel Cellular Microcultures via Direct Ink Writing (Adv. Healthcare Mater. 9/2016) (2016)

R. Nuzzo and co-workers show on page 1025 how compositional differences in hydrogels are used to tune their cellular compliance by controlling their polymer mesh properties and subsequent uptake of the protein poly-l-lysine (green spheres in circled inset). The cover image shows pyramid micro-scaffolds prepared using direct ink writing (DIW) that differentially direct fibroblast and preosteoblast growth in 3D, depending on cell motility and surface treatment.
Solvation Effects on Dilatancy in Concentrated PVC Plastisols (1982)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. J. Willey, C. W. Macosko; Solvation Effects on Dilatancy in Concentrated PVC Plastisols. J. Rheol. 1 December 1982; 26 (6): 557–564. https://doi.org/10.1122/1.549677 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
HF Characterization and Nonlinear Modeling of a Gapped Toroidal Magnetic Structure (2006)

The frequency dependent characteristics of a gapped toroidal structure are extracted empirically over a bandwidth that exceeds 30MHz. The analysis is complicated due to nonlinear flux distributions, magnetic properties of the core material, leakage inductance, stray capacitances, and eddy currents in the windings. A permeance model of the core is implemented to model the magnetic circuit. The model includes a linear lumped element equivalent circuit to approximate the nonlinear complex permeability of the core, which was measured empirically. Stray capacitance and inductance of the winding are also modeled. A gyrator is used to couple the electric and magnetic models for circuit simulation. The measured and simulated results of open-circuit impedance from the secondary winding and the transimpedance gain (V/A) of the current sensor are compared and discussed
Integrated UPLC-HRMS based metabolomics investigating hydroxytyrosol effect in human obesity (2019)

Based on World Health Organization recent data, obesity is regarded as a major public health problem [1]. So far, several in vivo studies and experimental models investigate the effect of olive oil (OO) biophenols and particular hydroxytyrosol (HT), a strong antioxidant entity of OO, in these metabolic diseases [2]. Promising results have been uncovered and nowadays research focuses on the exploration of HT effects on human metabolome.
Multi‐Numerology Waveform Parameter Assignment in 5G (2020)

Multi-numerology waveform is one of the fundamental topics in 5G communications systems. It provides flexibility while meeting the requirements of the new generation of cellular communications. Besides, waveform parameter assignment to users and services becomes a new research opportunity. This work aims to draw attention to the topic of waveform parameter assignment regarding resource allocation and scheduling. In this respect, a review of waveform parameter assignment is presented around different multi-numerology waveform papers in the literature. Moreover, numerology assignment, waveform processing, and the related joint optimization issues are discussed as a case study of waveform parameter assignment with multiple numerologies in 5G new radio.
Analysis of walk for quadruped (2002)

The authors investigate animal gaits and compare them with robot gaits in order to determine the parameters of the dynamic walk of robots. Several parameters are introduced to analyze gaits. These parameters can be normalized, using the equation of motion of an inverted pendulum. The experimental relations among the parameters give a gait which is efficient.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Studies on Crystalline d-Amino Acid Oxidase (1967)

Abstract The radiolabeled protein derivative obtained after treatment with sodium borohydride of a suitable reaction mixture permitting interaction of crystallized d-amino acid oxidase and the substrate d-alanine-1-14C has been identified as a reduction product of an enzyme-substrate intermediate involving the e-amino group of a lysyl residue of the enzyme protein. Acid hydrolysis of the protein and appropriate resolution of the hydrolysate have provided evidence of the identity of the labeled fragment with e-N-(1-carboxyethyl)-l-lysine which has been synthesized and characterized in this work. Initial intermediate combination of the substrate with the isoalloxazine ring of the flavonucleotide had been postulated in interpretation of the results of studies leading to the current investigation. It is of interest that a stable linkage of the amino acid skeleton with flavin adenine dinucleotide was found to be absent as a component of the final reduced protein product when d-alanine had been used as substrate. Our earlier hypothesis concerning the mechanism of catalysis by d-amino acid oxidase has been amplified with suggestions regarding the possible role in the enzymatic process of a particular lysyl residue of the enzyme-protein.
The Lurcher Mutation of an α-Amino-3-hydroxy-5-methyl- 4-isoxazolepropionic Acid Receptor Subunit Enhances Potency of Glutamate and Converts an Antagonist to an Agonist (2000)

A point mutation of the GluRdelta2 (A654T) glutamate receptor subunit converts it into a functional channel, and a spontaneous mutation at this site is thought to be responsible for the neurodegeneration of neurons in the Lurcher mouse. This mutation is located in a hydrophobic region of the M3 domain of this subunit, and this alanine is conserved throughout many of the glutamate receptors. We show here that site-directed mutagenesis of the homologous alanine (A636T; GluR1-L(c)) in the GluR1 AMPA receptor subunit alters its channel properties. The apparent potencies of both kainate and glutamate were increased 85- and 2000-fold, respectively. Furthermore, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)was converted from a competitive antagonist into a potent agonist. Our results demonstrate that a single amino acid within or near the putative second transmembrane region of the GluR1 subunit is critical for the binding/gating properties of this AMPA receptor.
A torsional model of multi-stage gears – influence of external excitations and tooth shape modifications (2016)

In this paper, a torsional dynamic model of multi-stage idler spur and helical gears is presented which combines mesh internal excitations and external forcing terms such as time-varying external torque. Each contact line in the various base planes is discretized in elemental cells which are all attributed a time-varying mesh stiffness element and initial separation to account for tooth shape deviations from ideal involute flanks. The mesh stiffness functions are estimated from the formulae of Weber & Banaschek and their relative phasing is determined based on gear geometry and relative positioning. The corresponding non-linear differential system is solved by combining a Newmark’s numerical time-step integration scheme and a normal contact algorithm. A number of simulation results are presented on the combined influence on dynamic tooth loads of errors and shape deviations along with external excitations.
The Effects of Biosynthetic Human Proinsulin on Carbohydrate Metabolism (1984)

Large quantities of biosynthetic human proinsulin have recently become available through recombinant DNA technology. Since the in vivo effects of human proinsulin have not been studied in man, we compared the dose-response relationship for stimulation of glucose disposal and suppression of hepatic glucose output by proinsulin and insulin. Ten normal subjects were studied using the euglycemic glucose clamp technique. The human proinsulin and insulin infusion rates were chosen to achieve steady-state proinsulin levels 10-fold higher than insulin levels on a molar basis, based on previous observations that porcine proinsulin has approximately 10% the potency of insulin. Proinsulin infusion rates of 2.75, 7.5, 22.5, and 45 micrograms/m2/min were compared with insulin infusion rates of 0.63, 1.67, 5, and 10 micrograms/m2/min. Primed, continuous infusions of insulin yielded steady-state levels within 25 min, whereas proinsulin levels did not reach a steady state for 120-180 min. The metabolic clearance rate of insulin was 11-12 ml/kg/min at the lower infusion rates but fell to 8.4 ml/kg/min at the highest infusion rate. The metabolic clearance rate of proinsulin was 3.0-3.5 ml/kg/min at all infusion rates. Dose-response analysis demonstrated that proinsulin-mediated glucose disposal was approximately 8% that of insulin. In contrast, proinsulin-mediated suppression of hepatic glucose output was approximately 12% that seen with insulin.(ABSTRACT TRUNCATED AT 250 WORDS)
Up to 2.5-kW on non-PM fiber and 2.0-kW linear polarized on PM fiber narrow linewidth CW diffraction-limited fiber amplifiers in all-fiber format (2018)

We report test data for narrow linewidth fiber amplifiers in a compact modular package and in all-fiber format with power up to 2.5kW and 2.0kW in non-PM and PM fiber configuration respectively for various scientific and advanced applications. Both fiber amplifiers have been pumped directly by laser diodes and have 3m output delivery cable. The fiber amplifiers have more than 35% wall-plug efficiency. Measured M<sup>2</sup> values are &le; 1.1. The amplifier data are discussed for different input linewidth and test conditions.
Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms (2016)

Oral diseases such as caries and periodontitis are mainly caused by microbial biofilms. Antibiotic therapy has reached its limits with regard to antimicrobial resistance, and new therapeutic measures utilizing natural phytochemicals are currently a focus of research. Hence, this systematic review provides a critical presentation of the antimicrobial effects of various medicinal herbs against in vitro, ex vivo, and in situ formed multispecies oral biofilms. Searches were performed in three English databases (PubMed, EMBASE, CAMbase) and the electronic archives of five German journals from the times of their establishment until October 10th, 2014, with the search terms "(plant extracts OR herbal extracts OR plant OR herb) AND (oral biofilm OR dental biofilm OR dental plaque OR oral disease OR dental disease)." The pooled data were assessed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Initially, 1848 articles were identified, out of which 585 full-text articles were screened, 149 articles were reevaluated for eligibility and finally, 14 articles met all inclusion criteria. The data of 14 reports disclosed enhanced antiadhesive and antibiofilm activity by the plant extracts obtained from Vitis vinifera, Pinus spp., Coffea canephora, Camellia sinensis, Vaccinium macrocarpon, Galla chinensis, Caesalpinia ferrea Martius, Psidium cattleianum, representative Brazilian plants and manuka honey. Overall, a positive correlation was revealed between herb-based therapies and elimination rates of all types of multispecies oral biofilms. In that context, integrating or even replacing conventional dental therapy protocols with herbal-inspired treatments can allow effective antimicrobial control of oral biofilms and thus, dental diseases.
Effects of hyperoxia on fibrinogen metabolism and clotting factors in rabbits. (1974)

After breathing 1 atmosphere of oxygen for 48 to 90 hours, 26 rabbits manifested increased concentrations of fibrinogen. Serial measurements of fibrinogen degradation products in 9 animals showed rising titers. The half-time of fibrinogen, which was measured in 6 animals, was shortened as compared with control animals that breathed air. The high oxygen exposure was not accompanied by statistically significant alterations in platelet count, prothrombin time, partial thromboplastin time, concentrations of inhibitor to activated factor X, concentrations of factors II, VII, VIII, IX, X, or euglobulin lysis time. Animals exposed to one hundred per cent oxygen for more than 48 hours had increased concentrations of factor V. These data suggested that hyperoxia in rabbits leads to abnormalities consistent with a low level thrombotic process. The mechanisms of the abnormalities are obsure, but release of thromboplastic substances or other proteolytic enzymes from lung tissue injured by oxygen is a possibility.
2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure (2011)

The aggregation of human amylin to form amyloid contributes to islet β-cell dysfunction in type 2 diabetes. Studies of amyloid formation have been hindered by the low structural resolution or relatively modest time resolution of standard methods. Two-dimensional infrared (2DIR) spectroscopy, with its sensitivity to protein secondary structures and its intrinsic fast time resolution, is capable of capturing structural changes during the aggregation process. Moreover, isotope labeling enables the measurement of residue-specific information. The diagonal line widths of 2DIR spectra contain information about dynamics and structural heterogeneity of the system. We illustrate the power of a combined atomistic molecular dynamics simulation and theoretical and experimental 2DIR approach by analyzing the variation in diagonal line widths of individual amide I modes in a series of labeled samples of amylin amyloid fibrils. The theoretical and experimental 2DIR line widths suggest a "W" pattern, as a function of residue number. We show that large line widths result from substantial structural disorder and that this pattern is indicative of the stable secondary structure of the two β-sheet regions. This work provides a protocol for bridging MD simulation and 2DIR experiments for future aggregation studies.
An Infrared Study of the Interaction of Dinitrogen with Dihydrogen over Supported Rhodium Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Infrared Study of the Interaction of Dinitrogen with Dihydrogen over Supported Rhodium FilmsZ. Pei, T. H. Fang, and S. D. WorleyCite this: J. Phys. Chem. 1995, 99, 11, 3663–3670Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/j100011a038https://doi.org/10.1021/j100011a038research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts