gebhart/patrepeval huggingface dataset:
Ductal Carcinoma In Situ of the Breast: Can Biomarkers Improve Current Management? (2013)

DCIS is a low-risk disease, its incidence is increasing, and current treatment is effective. However, many women are either over- or undertreated. Despite repeated calls for development of diagnostic biomarkers, progress in this area has been slow, reflecting a relative lack of investment of research effort and funding. Given the low event rate in treated patients and the lateness of recurrences, many previous studies have only limited power to identify independent prognostic and predictive biomarkers. However, the potential for such biomarkers to personalize treatment for DCIS is extremely high.
A quasi-periodic modulation strategy to mitigate EMI for a GaN-based quasi-Z-source DC-DC converter (2016)

Wide-bandgap (WBG) switching devices, such as gallium nitride (GaN), enable switching at high frequencies with low rise and fall times. This provides advantages such as high power density and compact size, however a potential unwanted side-effect is increased electromagnetic interference (EMI) because of large transient currents. A novel quasi-periodic modulation scheme is described for voltage-fed quasi-Z-source (qZS) DC-DC converters which substantially reduces the peak EMI. The driver logic required is simple and generic, and therefore adaptable to all modulation schemes proposed to date for isolated qZS DC-DC converters. Various experimental results verify the effectiveness of the proposed strategy in terms of voltage gain, efficiency and EMI suppression.
3D-TV R&D Activities in Europe (2011)

3D-TV is a topic that has been studied for many years in Europe. Through the research frameworks of the European Commission in particular, a number of long-term issues have been addressed to overcome limitations of the traditional two-view stereoscopy. This article gives a brief overview of the goals and achievements of some completed European projects starting in the 1990s. It then reviews the topics related to 3D-TV in recent European research. Finally an overview with a selection of recent projects is presented.
Channel structure design, fabrication and carrier transport properties of strained-Si/SiGe-on-insulator (strained-SOI) MOSFETs (2004)

This paper reviews the current critical issues regarding the device design of strained-Si MOSFETs and demonstrates that strained-Si-on-insulator (strained-SOI) structures can effectively solve these problems. The advantages, characteristics and challenges of strained-SOI CMOS technology are presented, on the basis of our recent results. Furthermore, a future possible direction of channel engineering using strained-Si/SiGe structures, into the deep sub-100 nm regime, is addressed.
Spectroscopic properties of transparent Y_3Al_5O_12: Eu ceramics (2013)

Yttrium aluminum garnet transparent ceramics with divalent or trivalent europium ion doping were prepared by vacuum sintering at 1780 °C. Refined XRD data confirmed the pure phase ceramic with little lattice expansion. The transmittance of the 1.1 mm thick blue color divalent europium doped sample was measured to be 61% at wavelength of 900 nm. The photoluminescence spectrum exhibited the typical broad emission related to divalent europium ions. Furthermore, the photoluminescence spectra of the samples with different europium doping concentration and different annealing temperature were compared.
Data structures in the multicore age (2011)

The advent of multicore processors as the standard computing platform will force major changes in software design.
Enhancing Technology-Mediated Communication: Tools, Analyses, and Predictive Models (2007)

For most of us, interpersonal communication is at the center of our professional and personal lives. With the growing distribution of business organizations and of our social networks, so grows the need for and use of communication technologies. Many of today's communication tools, however, suffer from a number of shortcomings. For example, the inherent discrepancy between one's desire to initiate communication and another's ability or desire to receive it, often leads to unwanted interruptions on the one hand, or failed communication on the other. I have taken an interdisciplinary approach to address these shortcomings, and also in order to provide a better understanding of human behavior and the use of communication tools, combining tool-building and the creation of predictive models, with investigation and analysis of large volumes of field data. At the focus of this dissertation is my research on Instant Messaging (IM) communication, a popular, interesting, and highly observable point on the continuum between synchronous and asynchronous communication mediums. I present the creation of a set of statistical models that are able to predict, with high accuracy, users' responsiveness to incoming communication. A quantitative analysis complements these models by revealing major factors that influence responsiveness, illuminating its role in IM communication. I then describe an investigation of the effect of interpersonal relationships on communication, and statistical models that can predict these relationships. Finally, I describe a tool I have created that allows users to balance their responsiveness to IM with their ability to stay on task.
Cobalt chromium perpendicular magnetic recording media: a corrosion study (1988)

An electrochemical and environmental chamber study of the effects of corrosion on the magnetic properties of various cobalt chromium thin-film compositions is reported. The propensity of these various materials towards corrosion is delineated, with suggestions for an optimum composition with respect to corrosion resistance. The effects of the presence of a titanium seed layer and those of a soft nickel/iron keeper layer on the corrosion resistance of the recording medium are studied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Head-to-tail photodimerization of a thiophene in a co-crystal and a rare adipic acid dimer in the presence of a heterosynthon (2014)

Head-to-tail photodimerization of thiophene is achieved in a co-crystal while a co-crystal with an acid dimer and heterosynthon is also described.
Tuning Optical Conductivity of Large‐Scale CVD Graphene by Strain Engineering (2013)

A controllable optical anisotropy in CVD graphene is shown. The transparency in the visible range of pre-strained CVD graphene exhibits a periodic modulation as a function of polarization direction. The strain sensitivity of the optical response of graphene demonstrated here can be effectively utilized towards novel ultra-thin optical devices and strain sensing applications.
Are Lock-Free Concurrent Algorithms Practically Wait-Free? (2013)

Lock-free concurrent algorithms guarantee that some concurrent operation will always make progress in a finite number of steps. Yet programmers prefer to treat concurrent code as if it were wait-free, guaranteeing that all operations always make progress. Unfortunately, designing wait-free algorithms is generally a very complex task, and the resulting algorithms are not always efficient. While obtaining efficient wait-free algorithms has been a long-time goal for the theory community, most non-blocking commercial code is only lock-free. This paper suggests a simple solution to this problem. We show that, for a large class of lock- free algorithms, under scheduling conditions which approximate those found in commercial hardware architectures, lock-free algorithms behave as if they are wait-free. In other words, programmers can keep on designing simple lock-free algorithms instead of complex wait-free ones, and in practice, they will get wait-free progress. Our main contribution is a new way of analyzing a general class of lock-free algorithms under a stochastic scheduler. Our analysis relates the individual performance of processes with the global performance of the system using Markov chain lifting between a complex per-process chain and a simpler system progress chain. We show that lock-free algorithms are not only wait-free with probability 1, but that in fact a general subset of lock-free algorithms can be closely bounded in terms of the average number of steps required until an operation completes. To the best of our knowledge, this is the first attempt to analyze progress conditions, typically stated in relation to a worst case adversary, in a stochastic model capturing their expected asymptotic behavior.
Application of the port-reduction method in the design synthesis of EBGs for antenna systems (2015)

A metasurface consisting of a mushroom-type electromagnetic band gap structure (EBG) is proposed as a means of reducing the mutual coupling between antenna arrays. By capacitively loading the unit cells, not only is the size of the EBG reduced, but also the port-substitution method can be employed to optimize the antenna-EBG system. Simulation results show improvement of mutual coupling and return loss by allowing the EBG to be optimized in conjunction with the antenna array, rather than designing them separately and then combining them together after the fact. A mutual coupling reduction of 11.64 dB was achieved for the optimized antenna-EBG structure when compare with the case of no EBG.
On the TDD subframe structure for beyond 4G radio access network (2013)

The purpose of a Beyond 4G (B4G) radio access technology, is to cope with the expected exponential increase of mobile data traffic in local area (LA). The<br/>requirements related to physical layer control signaling latencies and to hybrid ARQ (HARQ) round trip time (RTT) are in the order of ~1ms. In this paper, we propose a flexible orthogonal frequency division multiplexing (OFDM) based time division duplex (TDD) physical subframe structure optimized for B4G LA environment. We show that the proposed optimizations allow very frequent link direction switching, thus reaching the tight B4G HARQ RTT requirement and significant control signaling latency reductions compared to existing LTE-Advanced and WiMAX technologies.
Dielectrophoretic separation of blood pathogens ou Bacterial extraction from biological samples using DEP forces (2012)

International audience
Higher Estimated Net Endogenous Acid Production May Be Associated with Increased Prevalence of Nonalcoholic Fatty Liver Disease in Chinese Adults in Hong Kong (2015)

Nonalcoholic fatty liver disease (NAFLD) has been associated with reduced growth hormone levels and signaling. Such hormonal changes also occur in metabolic acidosis. Since mild metabolic acidosis can be diet induced, diet-induced acid load may constitute a nutritional factor with possible influence on NAFLD development. This study explored whether a higher diet-induced acid load is associated with an increased likelihood of NAFLD. Apparently healthy Chinese adults (330 male, 463 female) aged 19-72 years were recruited through population screening between 2008 and 2010 in a cross-sectional population-based study in Hong Kong. Estimated net endogenous acid production (NEAP) was calculated using Frassetto's method and potential renal acid load (PRAL) was calculated using Remer's method based on dietary data from a food frequency questionnaire. NAFLD was defined as intrahepatic triglyceride content at >5% by proton-magnetic resonance spectroscopy. Possible advanced fibrosis was defined as liver stiffness at >7.9 kPa by transient elastography. Multivariate logistic regression models were used to examine the association between each measure of dietary acid load and prevalent NAFLD or possible advanced fibrosis with adjustment for potential anthropometric and lifestyle factors. 220 subjects (27.7%) were diagnosed with NAFLD. Estimated NEAP was positively associated with the likelihood of having NAFLD after adjustment for age, sex, body mass index, current drinker status and the presence of metabolic syndrome [OR (95% CI) = 1.25 (1.02-1.52), p = 0.022]. The association was slightly attenuated but remained significant when the model was further adjusted for other dietary variables. No association between PRAL and NAFLD prevalence was observed. Both estimated NEAP and PRAL were not associated with the presence of possible advance fibrosis. Our findings suggest that there may be a modest association between diet-induced acid load and NAFLD. More studies are needed to ascertain the link between diet-induced acid load and NAFLD and to investigate the underlying mechanisms.
A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer (2020)

In summary, we propose a predictive and prognostic model of g<i>BRCA</i>-mutated PDAC on the basis of HRD genomic hallmarks, Ki67 index, tumor ploidy, and transcriptomic subtype.
Comparative Study of Lipo PGE1 and PGE1-CD on Patency after Microvascular Anastomosis. (1997)

Prostaglandin E1 (PGE1) has already been shown to improve vascular patency in experimental microvascular anastomosis. It is also widely used following clinical microvascular anastomosis. We designed a prospective study to compare the efficacy of Lipo PGE1 and PGE1-CD (PGE1-α-cyclodextrin) in 34 patients (14 free tissue transfers and 20 digital replantations). Dosage of Lipo PGE1 was 10μg daily for an average of 8 days and that of PGE1-CD was 120μg (60μg×2) for an average of 6 days. Success in microvascular anastomosis was evaluated by survival of the flap or replanted finger after 2 weeks. The success rate of free tissue transfers for the lipo PGE1 group was 100% and that of the PGE1-CD group was 75%. The success rate of digital replantations for the lipo PGE1 group was 88% and that of the PGE1-CD group was 75%. There was no significant difference between the two groups. Four of the 16 patients receiving PGE1-CD complained of vascular pain during injection, whereas, none complained of vascular pain in the group receiving lipo PGE1. Lipo PGE1 showed at least the same efficacy on patency after microvascular surgery as PGE1-CD with less vascular pain.
LONG-TERM CARDIOVASCULAR MORBIDITY AND MORTALITY IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PATIENTS AFTER RENAL TRANSPLANTATION (1994)

Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased incidence of hypertension and cardiovascular abnormalities. In this long-term follow-up study (5.88 years on average), we evaluated cardiovascular disease and patient and graft survival in 101 ADPKD patients and 692 nondiabetic control patients receiving cadaveric renal transplants between March 1967 and April 1991 at the Leiden University Hospital. Graft and patient survival was not different between patient groups, using the same immunosuppressive therapy. However, death with functioning graft, mainly due to cardiovascular disease, was significantly more frequent in the ADPKD patients than in controls using AZA (P < 0.01). Multivariate analysis of pretransplant data showed that ADPKD patients on AZA therapy demonstrated an elevated age-adjusted relative risk of 2.07 (95% confidence interval [95% CI]: 1.12-3.80) for cardiovascular events and 2.88 (95% CI: 1.41-5.90) for cardiovascular mortality alone. After adjustment for age, gender, and other cardiovascular risk factors, a relative risk of 2.39 (95% CI: 1.06-5.40) was found. This was 2.87 (95% CI: 1.04-7.93) when cardiovascular mortality was the dependent variable. With posttransplant data, the age-adjusted relative risk for cardiovascular morbidity and mortality in ADPKD patients using AZA was 2.16 (95% CI: 1.12-4.15) and 2.97 (95% CI: 1.40-6.27), with only cardiovascular mortality as the dependent variable. After adjustment for age, gender, and other cardiovascular risk factors, this was 1.59 (95% CI: 0.64-3.91) and 2.28 (95% CI: 0.79-6.53), respectively. With CsA treatment, an elevated risk for cardiovascular morbidity and mortality in ADPKD patients was present, but the corresponding 95% CI were wide and include unity, due to the shorter period of follow-up (CsA: 3.81 +/- 2.50 years vs. AZA: 7.28 +/- 6.74 years). Survival of ADPKD patients using AZA was less in those patients without pretransplant nephrectomy as compared with control patients, but the morbidity and mortality of pretransplant nephrectomies should be taken into account. We conclude that ADPKD patients show a similar graft and patient survival after renal transplantation as control patients, but they are especially at risk for cardiovascular disease after renal transplantation.
Event-based YOLO object detection: proof of concept for forward perception system (2023)

Neuromorphic vision or event vision is an advanced vision technology, where in contrast to visible camera sensors that output pixels, the event vision generates neuromorphic events every time there’s a brightness change which exceeds a specific threshold in the field of view (FoV). This study focuses on leveraging neuromorphic event data for roadside object detection. This is a proof of concept towards building artificial intelligence (AI) based imaging pipelines which can be used for forward perception systems for advanced vehicular applications. The focus is on building efficient stateof- the-art object detection networks with better inference results for fast-moving forward perception using an event camera. In this article, the event simulated A2D2 dataset is manually annotated and trained on two different YOLOv5 networks (small and large variants). To further assess its robustness, single model testing and ensemble model testing are carried out.
Nanocolloidal microarrays on chemically patterned substrates (2005)

The self-assembly of nanosized colloidal particles on patterned substrates offers a convenient way of building nanostructures in an efficient way through a bottom-up approach. Combining such self-assembly methods with conventional top-down micro- and nanofabrication methods may lead to new devices with a structural hierarchy ranging from the nano/molecular to the macroscopic level. In this work, the self-assembly of functionalized nanosized silica particles on chemically structured substrates is studied. A newly developed chemical patterning method offering good control of the surface chemistry is used to selectively bind functionalized nanocolloids at distinct spots on the surface. Such nanocolloidal microarrays offer the potential to be used to increase the sensitivity of existing biosensing applications due to the well-defined surface chemistry (of particle and substrate) and the highly increased surface area at the microspots where the nanocolloidal particles self-assemble.
Plasma Switch-Based Technology for High-Speed and High-Power Impedance Tuning (2021)

This paper introduces a new technology for a high-speed, high-power mobile form-factor tuner utilizing gas discharge tube plasma cells as switching components. To the best of our knowledge, this represents the first plasma-enabled RF matching network. Technology development is reviewed, the fabrication and measurement of a proof-of-concept switched stub impedance tuner are presented, and techniques for improvement are discussed. The proof-of-concept impedance tuner functions with a 27% bandwidth from 3 to almost 4 GHz and shows a power gain better than -2.5dB across all switching state-frequency combinations at a 50 W input power level with spread coverage of the Smith chart. State change transient timing is measured to be on the order of 500 ns. This technology demonstration highlights the potential of miniaturized, rapidly-tunable, high-power, plasma-based RF devices.
Biomechanical Comparison of Inflatable Penile Implants: A Cadaveric Pilot Study (2018)

The results of this study support the conclusion that all devices are capable of functionally restoring erectile capacity. However, we observed that, in general, the 2 circumferentially expanding penile prosthesis showed greater resistance in biomechanical testing when compared with longitudinal and circumferential expanding devices. This should be considered as a guide during device selection for a patient undergoing penile prosthesis. Wallen JJ, Barrera EV, Ge L, et al. Biomechanical Comparison of Inflatable Penile Implants: A Cadaveric Pilot Study. J Sex Med 2018;15:1034-1040.
Drought stress promotes xylem differentiation by modulating the interaction between cytokinin and jasmonic acid (2018)

Drought stress provokes jasmonic acid (JA) signaling, which mediates plant stress responses; moreover, growing numbers of studies suggest that JA is involved in the modulation of root development under drought stress. Recently, we showed that JA promotes differentiation of xylem from procambial cells in Arabidopsis roots. Further molecular and genetic approaches revealed that the effect of JA on xylem development is caused by suppression of cytokinin responses, suggesting that JA antagonistically interacts with cytokinin to modulate xylem development. Here, we showed that, similar to JA, drought stress promotes xylem development. This suggests that the antagonistic interaction between JA and cytokinin is involved in drought-mediated xylem development, a hypothesis supported by the observation that drought stress increases JA responses and decreases cytokinin responses. Based on these findings, we propose that drought stress promotes xylem development, and the antagonistic interaction between JA and cytokinin is deeply involved in this process.
Alkylation of phenol with camphene in the presence of heteropolyacids supported on metal oxides (2013)

Alkylation of phenol with camphene in the presence of supported heteropolyacids is studied. The main reaction products are found to be phenyl isobornyl ether, 2-isobornylphenol and 2-isocamphylphenol, the ratio between them being determined by the nature of heteropolyacid and carrier (ZrO2 or TiO2).
Time structure of pencil beam scanning proton FLASH beams measured with scintillator detectors and compared with log files (2022)

Fiber-coupled scintillator detectors were designed with sufficient temporal resolution to measure the spot and transition duration during PBS proton UHDR deliveries. Their small volume makes them feasible for in vivo use in preclinical FLASH studies. The logged spot durations were in excellent agreement with measurements but showed small systematic errors in the logged duration for the first and last spot in a sequence.
ChemInform Abstract: Infrared Spectroscopic Studies of the Reactions of Copper and Ammonia in Cryogenic Argon Matrices. (1989)

Abstract Prolonged photolysis of cocondensed Cu and NH 3 in a cryogenic Ar matrix leads to two new sets of absorptions in addition to that of the Cu‐NH3 adduct.