gebhart/patrepeval huggingface dataset:
Glioma tropism of lentivirally transduced hematopoietic progenitor cells (2010)

Experimental gliomas attract hematopoietic progenitor cells (HPC) in vivo. HPC are therefore promising candidates for a cell-based delivery of therapeutic molecules to experimental gliomas. A therapeutic application requires efficient genetic manipulation of the cellular vector and a lack of tumorigenicity. Here, we studied the impact of lenti-viral transduction on the glioma tropism of human or murine HPC. Transduction of human or murine HPC with a GFP lentivirus (lenti-GFP) did not interfere with the glioma-mediated attraction of HPC. Bone marrow reconstitution of C57Bl/6 mice with syngeneic GFP-transgenic lineage-depleted bone marrow cells (lin- BM) was as efficient as reconstitution with syngeneic lin- BM transduced ex vivo with lenti-GFP. SMA-560 gliomas growing orthotopically in lenti-GFP-reconstituted VM/Dk mice recruited GFP-positive bone marrow-derived cells. Thus, lentiviral transduction did not interfere with the attraction of exogenously injected HPC or endogenous bone marrow-derived cells by experimental gliomas. Lenti-GFP-HPC implanted directly into tumor-free brains were not tumorigenic. The intravenous injection of lenti-GFP-HPC in glioma-bearing mice did not alter the survival of otherwise untreated animals and had no impact on the survival benefit conferred by cerebral irradiation. Taken together, genetic manipulation of HPC with lenti-GFP neither made these cells tumorigenic nor interfered with their glioma tropism.
Gas permeation resistance of a perfluoroalkoxy‐tetrafluoroethylene copolymer (2006)

Abstract The permeation resistance of perfluoroalkoxy (PFA), a polytetrafluoroethylene (PTFE) copolymer, to various gases was explored. The diffusion and permeability coefficients for hydrogen, oxygen, nitrogen, and air were measured with extruded films using standard manometric techniques. For thicker films, transport properties were independent of film thickness. For the thinnest films, the diffusivity and permeability coefficients were slightly higher because of reduced crystallinity. The solubility of these apolar permeants in PFA was quite low and behaved ideally. Therefore, the permeation characteristics of air could be calculated from those of nitrogen and oxygen. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 2122–2125, 2006
Automated Filter Pruning Based on High-Dimensional Bayesian Optimization (2022)

Filter pruning is necessary to efficiently deploy convolutional neural networks on edge devices that have limited computational resources and power budgets. With conventional filter pruning techniques, the same pruning rate is manually specified for different convolutional layers, which is suboptimal and time-consuming. To extract the features from the coarse level to the fine level, the number of filters in each layer has various distributions. Therefore, it is unsuitable to utilize the same pruning rate for different functional layers. To address this issue, we propose a high-dimensional Bayesian optimization-based filter pruning (HDBOFP) algorithm, which aims to automatically determine the most appropriate pruning rate for each convolutional layer. In addition, the proposed method can automatically identify optimal pruning-rate combinations without a time-consuming retraining phase. Compared with conventional filter pruning methods, this automated filter pruning technique exhibits a higher efficiency, which improves accuracy and reduces the required human labor. The effectiveness of our automated filter pruning algorithm is validated through two major computer vision applications, namely image classification and object detection. Specifically, when used in combination with ResNet-110 to classify the CIFAR-10 dataset, HDBOFP reduces the required number of float point operations (FLOPs) by more than 62% without affecting accuracy. Similarly, when HDBOFP is added to the YOLOv5l framework to run detection experiments on the MS-COCO 2017 dataset, FLOPs decrease by more than 43% with only a 1.2% loss in mean average precision, which has advanced the previous studies.
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat (1981)

An atlas of the distribution of cholinergic cell bodies, fibers, and terminals, as well as cholinoceptive cells, in the central nervous system of the cat (excluding the cerebellum) is presented from results obtained in immunohistochemical work on choline acetyltransferase. Cholinergic cell bodies are observed in more than forty areas, and cholinoceptive cells in sixty discrete areas of brain sections from the spinal cord to the olfactory bulb. The atlas is presented in seventy cross-sectional drawings of cat brain extending from the olfactory bulb to the upper cervical spinal cord.
In situremediation of subsurface contamination: opportunities and challenges for nanotechnology and advanced materials (2019)

Engineered nanomaterials alone or in combination with other technologies may improve<italic>in situ</italic>subsurface remediation of legacy and emerging contaminants.
Power management system in the microgrid with the proper electric vehicle data preprocessing (2020)

This paper proposes power management method in the electric vehicle charging station with the consideration of the charging characteristics of the vehicles. In our model, charging facilities determine the amount of power supplied to the electric vehicle based on the pricing data and the peak load in the region. Especially, unlike the previous researches, the proposed model can be applied to a actual environment by analyzing the practical electric vehicle charging data that gathered from the facilities. By suggesting an appropriate data classification algorithm and an energy operation method, we could reduce peak load in the region more than 20% and reduce the total charge compared with the case that proper energy operation technology is not applied.
A micro-machined microphone based on field-effect-transistor and electrets (2011)

Micro-machined microphones are attracting attention of industry because of their benefit of size over conventional ones. Since most of micro-machined microphones are capacitive sensors, the sizes of their electrodes determine the low frequency noise level that increases with inverse of frequency (1/f). Therefore, the size of microphone itself becomes larger than one that can be fabricated. Here, we introduce a micro-machined microphone that can overcome the limit of capacitive microphones. The proposed microphone is composed of a field-effect-transistor (FET) and an electret. The difference between the conventional electret capacitive microphones and the proposed microphone may be the transduction mechanism: The change in the position of an electret causes the change in electric field on the gate of FET. Compared with capacitive transduction, the resistive channel of FET can be designed to have low sensor impedance, and subsequently have low impedance at low frequency. To make experimental specimen, FET onto membrane and electret was fabricated with conventional metal-oxide-semiconductor fabrication process and micromachining process, respectively. The FET membrane chip and the electret chip were assembled. Simple current to voltage converter was applied as a pre-amplifier. Its feasibility to apply low frequency acoustic sensor will be proved by simulation and experimental results.
Heat Shock Proteins Affect RNA Processing during the Heat Shock Response of Saccharomyces cerevisiae (1991)

In the yeast Saccharomyces cerevisiae, the splicing of mRNA precursors is disrupted by a severe heat shock. Mild heat treatments prior to severe heat shock protect splicing from disruption, as was previously reported for Drosophila melanogaster. In contrast to D. melanogaster, protein synthesis during the pretreatment is not required to protect splicing in yeast cells. However, protein synthesis is required for the rapid recovery of splicing once it has been disrupted by a sudden severe heat shock. Mutations in two classes of yeast hsp genes affect the pattern of RNA splicing during the heat shock response. First, certain hsp70 mutants, which overproduce other heat shock proteins at normal temperatures, show constitutive protection of splicing at high temperatures and do not require pretreatment. Second, in hsp104 mutants, the recovery of RNA splicing after a severe heat shock is delayed compared with wild-type cells. These results indicate a greater degree of specialization in the protective functions of hsps than has previously been suspected. Some of the proteins (e.g., members of the hsp70 and hsp82 gene families) help to maintain normal cellular processes at higher temperatures. The particular function of hsp104, at least in splicing, is to facilitate recovery of the process once it has been disrupted.
A fully integrated novel Wafer-Level LED package (WL2P) technology for extremely low-cost solid state lighting devices (2012)

Reduction of cost has become the most important challenge for solid state lighting. We proposed a novel Wafer-Level LED Packaging (WL2P) technology, which enables both extremely low cost and small size for future solid state lighting. Where a conventional package needs individual assembly steps, resulting in high fabrication cost, we carried out from growth of the GaN layer, over formation of Inter Layer Dielectric (ILD), wiring for solder pad to printing the phosphor layer on a whole wafer in our WL2P. Thus, for the first time a fully integrated wafer-level process was successfully applied to light emitting diode (LED) devices. It was clearly demonstrated that our WL2P has an excellent thermal resistance as low as 24.2K/W in the 0.6×0.3mm size prototype structure because of the direct connection of Cu wiring to the light emitting layer and a maximum injection power density was as high as 1157W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a difference of 50°C between junction temperature and ambient temperature on the aluminum based printed wiring board (PCB)
GESPAR: Efficient Phase Retrieval of Sparse Signals (2013)

We consider the problem of phase retrieval, namely, recovery of a signal from the magnitude of its Fourier transform, or of any other linear transform. Due to the loss of the Fourier phase information, this problem is ill-posed. Therefore, prior information on the signal is needed in order to enable its recovery. In this work we consider the case in which the signal is known to be sparse, i.e., it consists of a small number of nonzero elements in an appropriate basis. We propose a fast local search method for recovering a sparse signal from measurements of its Fourier transform (or other linear transform) magnitude which we refer to as GESPAR: GrEedy Sparse PhAse Retrieval. Our algorithm does not require matrix lifting, unlike previous approaches, and therefore is potentially suitable for large scale problems such as images. Simulation results indicate that GESPAR is fast and more accurate than existing techniques in a variety of settings.
Cooperative Coding using Cyclic Delay for Multiuser OFDM Systems (2008)

In this paper, the cooperative coding using cyclic delay diversity (CDD) for multiuser OFDM systems is introduced. In proposed scheme, multiple terminals with a single antenna share their resources and exploit spatial diversity. Also, in order to increase frequency selectivity in the relay channel, different cyclic time delay is used at the relays. Analysis of frame error probability (FEP) for proposed cooperative coding using CDD is shown. Simulation results show the frame error rate (FER) for various consideration. The proposed scheme provides the diversity gain according to the number of relays and cyclic delay.
ChemInform Abstract: Synthesis of a Poly(ethylene glycol)‐Supported Tetrakis Ammonium Salt: A Recyclable Phase‐Transfer Catalyst of Improved Catalytic Efficiency. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Information from Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice (2023)

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ChemInform Abstract: Cationic Aqua Complexes of the C2‐Symmetric trans‐Chelating Ligand (R,R)‐4,6‐Dibenzofurandiyl‐2,2′‐bis(4‐phenyloxazoline). Absolute Chiral Induction in Diels—Alder Reactions Catalyzed by Water‐Tolerant Enantiopure Lewis Acids. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Carboxy Terminus of pp60c-src is a Regulatory Domain and is Involved in Complex Formation with the Middle-T Antigen of Polyomavirus (1988)

A large number of mutations were introduced into the carboxy-terminal domain of pp60c-src. The level of phosphorylation on Tyr-416 and Tyr-527, the transforming activity (as measured by focus formation on NIH 3T3 cells), kinase activity, and the ability of the mutant pp60c-src to associate with the middle-T antigen of polyomavirus were examined. The results indicate that Tyr-527 is a major carboxy-terminal element responsible for regulating pp60c-src in vivo. A good but not perfect correlation exists between lack of phosphorylation at Tyr-527 and increased phosphorylation at Tyr-416, between elevated phosphorylation on Tyr-416 and activated kinase activity, and between activated kinase activity and transforming activity. Phosphorylation of Tyr-527 was insensitive to the mutation of adjacent residues, indicating that the primary sequence only has a minor role in recognition by kinases or phosphatases which regulate it in vivo. Three mutants which have in common a modified Glu-524 residue were phosphorylated on Tyr-416 and Tyr-527 and were weakly transforming. This suggests that other mechanisms besides complete dephosphorylation of Tyr-527 can lead to increased phosphorylation of Tyr-416 and activation of the transforming activity of pp60c-src. Furthermore, the residues between Asp-518 and Pro-525 were required to form a stable complex with middle-T antigen. The proximity of these sequences to Tyr-527 suggests a model in which middle-T activates pp60c-src by binding directly to this region of the molecular and thereby preventing phosphorylation of Tyr-527. Alternatively, middle-T binding may mediate a conformational change in this region, which in turn induces an alteration in the level of phosphorylation at Tyr-527 and Tyr-416.
Application of array-based genomic and epigenomic technologies to unraveling the heterogeneous nature of breast tumors: on the road to individualized treatment. (2007)

The recent application of genomic microarray technology to the molecular profiling of breast tumors has clearly demonstrated their heterogeneous nature. Targeted treatment strategies are having a clear impact on patient survival. It has also become apparent that accumulated mutations, genomic instability, epigenetic phenomena, genetic variability and environmental factors all contribute to the uniqueness of a patient's tumor. Novel genomic and epigenetic-based technologies have been or are being developed in order to greatly enhance the analysis of tumor samples including those samples previously thought unusable due to the fixation process, such as archival formalin-fixed paraffin-embedded (FFPE) samples. Patients and their tumors can now be studied with regard to genetic variation, genomic instability, gene expression, gene mutations, and methylation patterns. These areas of research are being made more accessible through genome-wide screening technologies and will, in the near future, rapidly expand our understanding of what contributes to the unique properties of each tumor and lead to the identification of genes that could be potential therapeutic targets for specific tumor subtypes. Application of these technologies to our understanding of breast cancer will undoubtedly have an impact on the individualization of treatment for breast cancer patients in the not to distant future.
Perceptual image quality assessment metric that handles arbitrary motion blur (2011)

A fair knowledge of the human hand tremor responsible for camera-shake noise as well as a way to measure the impact of motion-blur on human-perceived image quality are mandatory to quantify the gain of image stabilization systems. In order to define specifications for the stabilization chain we have derived a perceptual image quality metric for camera-shake induced motion blur. This quality metric was validated with visual tests. Comparison to the ground-truth shows a good fitting in the simple case of straight-line motion blur as well as a fair fitting in the more complex case of arbitrary motion blur. To our best knowledge this is the first metric that can predict image quality degradation in the case of arbitrary blur. The quality model on which this metric is based gives some valuable insights on the way motion blur impacts perceived quality and can help the design of optimal image stabilization systems.
Verifying Sanitizer Correctness through Black-Box Learning: A Symbolic Finite Transducer Approach (2020)

String sanitizers are widely used functions for preventing injection attacks such as SQL injections and cross-site scripting (XSS). It is therefore crucial that the implementations of such string sanitizers are correct. We present a novel approach to reason about a sanitizer’s correctness by automatically generating a model of the implementation and comparing it to a model of the expected behaviour. To automatically derive a model of the implementation of the sanitizer, this paper introduces a black-box learning algorithm that derives a Symbolic Finite Transducer (SFT). This black-box algorithm uses membership and equivalence oracles to derive such a model. In contrast to earlier research, SFTs not only describe the input or output language of a sanitizer but also how a sanitizer transforms the input into the output. As a result, we can reason about the transformations from input into output that are performed by the sanitizer. We have implemented this algorithm in an open-source tool of which we show that it can reason about the correctness of non-trivial sanitizers within a couple<br/>of minutes without any adjustments to the existing sanitizers.
ATALA: Accelerator of TRLs for algorithms &amp; advanced processing: Application to ground radars (2014)

ATALA objective is to break TRL4/5 Wall to speed up insertion of innovative algorithms in Radar Sensors Products. ATALA is also a derisking tool for Engineering Teams & Customers. We will illustrate validation of ATALA with 2 Use-Cases results: monitoring of commercial aircraft wake-vortex, detection of small/slow synthetic targets on relevant clutter environment. ATALA is based on two main principles: SDR4U (Software Defined Radar for You), PAR4U (Automatic Parallelization for You).
Recombination Between the Sodium Channel SCN8A and the Allgrove Syndrome Gene in a Puerto Rican Kindred (2000)

Article Recombination Between the Sodium Channel SCN8A and the Allgrove Syndrome Gene in a Puerto Rican Kindred was published on July 1, 2000 in the journal International Journal on Disability and Human Development (volume 1, issue 3).
Epigenetic targeting of neuropilin-1 prevents bypass signaling in drug-resistant breast cancer (2020)

Human epidermal growth factor receptor 2 (HER2)-amplified breast cancers are treated using targeted antibodies and kinase inhibitors, but resistance to these therapies leads to systemic tumor recurrence of metastatic disease. Herein, we conducted gene expression analyses of HER2 kinase inhibitor-resistant cell lines as compared to their drug-sensitive counterparts. These data demonstrate the induction of epithelial-mesenchymal transition (EMT), which included enhanced expression of fibroblast growth factor receptor 1 (FGFR1) and axonal guidance molecules known as neuropilins (NRPs). Immunoprecipitation of FGFR1 coupled with mass spectroscopy indicated that FGFR1 forms a physical complex with NRPs, which is enhanced upon induction of EMT. Confocal imaging revealed that FGFR1 and NRP1 predominantly interact throughout the cytoplasm. Along these lines, short hairpin RNA-mediated depletion of NRP1, but not the use of NRP1-blocking antibodies, inhibited FGFR signaling and reduced tumor cell growth in vitro and in vivo. Our results further indicate that NRP1 upregulation during EMT is mediated via binding of the chromatin reader protein, bromodomain containing 4 (BRD4) in the NRP1 proximal promoter region. Pharmacological inhibition of BRD4 decreased NRP1 expression and ablated FGF-mediated tumor cell growth. Overall, our studies indicate that NRPs facilitate aberrant growth factor signaling during EMT-associated drug resistance and metastasis. Pharmacological combination of epigenetic modulators with FGFR-targeted kinase inhibitors may provide improved outcomes for breast cancer patients with drug-resistant metastatic disease.
Graphene-Complex-Oxide Nanoscale Device Concepts (2018)

The integration of graphene with complex-oxide heterostructures such as LaAlO<sub>3</sub>/SrTiO<sub>3</sub> offers the opportunity to combine the multifunctional properties of an oxide interface with the exceptional electronic properties of graphene. The ability to control interface conduction through graphene and understanding how it affects the intrinsic properties of an oxide interface are critical to the technological development of multifunctional devices. Here we demonstrate several device archetypes in which electron transport at an oxide interface is modulated using a patterned graphene top-gate. Nanoscale devices are fabricated at the oxide interface by conductive atomic force microscope (c-AFM) lithography, and transport measurements are performed as a function of the graphene gate voltage. Experiments are performed with devices written adjacent to or directly underneath the graphene gate. Distinct capabilities of this approach include the ability to create highly flexible device configurations, the ability to modulate carrier density at the oxide interface, and the ability to control electron transport up to the single-electron tunneling regime, while maintaining intrinsic transport properties of the oxide interface. Our results facilitate the design of a variety of nanoscale devices that combine excellent transport properties of these two proximal two-dimensional electron systems.
Holding the Internet Accountable (2018)

Today’s IP network layer provides little to no protection against misconfiguration or malice. Despite some progress in improving the robustness and security of the IP layer, misconfigurations and attacks still occur frequently. We show how a network layer that provides accountability, i.e., the ability to associate each action with the responsible entity, provides a firm foundation for defenses against misconfiguration and malice. We present the design of a network layer that incorporates accountability called AIP (Accountable Internet Protocol) and show how its features—notably, its use of self-certifying addresses— can improve both source accountability (the ability to trace actions to a particular end host and stop that host from misbehaving) and control-plane accountability (the ability to pinpoint and prevent attacks on routing).