gebhart/patrepeval huggingface dataset:
Dysregulated expression of histone deacetylases in medulloblastoma - potential targets for selective inhibitor treatment (2013)

Introduction: Medulloblastoma is the most common malignant brain tumor in childhood comprising 4 molecular subgroups. Survival rates remain particularly poor for patients with subgroup 3 tumors despite multimodal treatment. Therefore targeted therapies are urgently needed. Broad-spectrum inhibition of histone deacetylases (HDACs) has previously been shown to be a promising approach in cancer therapy. We here explore the possibility of isoenzyme-selective HDAC isozyme inhibition for treatment of MB.
Protective Efficacy of Vaccine Against Bovine Trichophytosis After Intramuscular, Subcutaneous and Intradermal Administration (1997)

Trichophyton verrllcosum after intramuscular and subcutaneous administration proved satisfactory, the proportions of calves thus protected being 100% and 9.+,7%, respectively. After intradermal administration only 62,S '7c of the calves were protected.
T+31C Polymorphism (M235T) of the Angiotensinogen Gene and Home Blood Pressure in the Japanese General Population: The Ohasama Study. (2003)

The angiotensinogen (AGT) gene polymorphism M235T (a methionine to threonine amino acid substitution) has been investigated in association with essential hypertension (EHT) based on conventional measurement of blood pressure (BP); however, the results have been inconsistent. Recently, we have been conducting lines of genetic analysis on a general population of Ohasama Town in Iwate Prefecture, Japan, who measured their BP at home (Ohasama genetic analysis and home BP project). We here assessed the association between AGT M235T polymorphism and hypertension within the same population (1,245 subjects aged 40 years and over). AGT M235T polymorphism was determined by genotyping the AGT T+31C polymorphism, which has complete disequilibrium with the AGT M235T polymorphism. We defined subjects as hypertensive if they were being treated with antihypertensive medication and/or had home BP values of more than 135 mmHg in systole and/or 85 mmHg in diastole. The genotype frequencies were similar to those in previous Japanese studies. There was no significant difference among the genotypes in home BP values (p = 0.63/0.74 for systolic/diastolic blood pressure) or in prevalence of hypertension (MM: 44.7%; MT: 42.3%; TT: 39.6%; p = 0.61). No difference was noted in the frequency of familial history of hypertension. Pulse pressure, however, was significantly different among the genotypes (p = 0.049), and this association was prominent in the older (age260) population (p = 0.0018), but not noted in the younger population (60 > age > or = 40). In conclusion, the present analysis confirmed the lack of a significant effect of AGT M235T polymorphism on blood pressure level, but the difference in pulse pressure in the older population suggests that further investigations of this polymorphism should be made in the Japanese population.
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors (2019)

Inhibitors of poly(ADP-ribose) polymerase (PARP) have demonstrated efficacy in women with BRCA-mutant ovarian cancer. However, only 15%-20% of ovarian cancers harbor BRCA mutations, therefore additional therapies are required. Here, we show that a subset of ovarian cancer cell lines and ex vivo models derived from patient biopsies are sensitive to a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. Sensitivity is due to underlying DNA replication vulnerabilities that cause persistent fork stalling and replication catastrophe. PARG inhibition is synthetic lethal with inhibition of DNA replication factors, allowing additional models to be sensitized by CHK1 inhibitors. Because PARG and PARP inhibitor sensitivity are mutually exclusive, our observations demonstrate that PARG inhibitors have therapeutic potential to complement PARP inhibitor strategies in the treatment of ovarian cancer.
Asymmetric catalysis. 80. Mechanistic aspects of the rhodium-catalyzed enantioselective transfer hydrogenation of .alpha.,.beta.-unsaturated carboxylic acids using formic acid/triethylamine (5:2) as the hydrogen source (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric catalysis. 80. Mechanistic aspects of the rhodium-catalyzed enantioselective transfer hydrogenation of .alpha.,.beta.-unsaturated carboxylic acids using formic acid/triethylamine (5:2) as the hydrogen sourceWalter Leitner, John M. Brown, and Henri BrunnerCite this: J. Am. Chem. Soc. 1993, 115, 1, 152–159Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ja00054a021https://doi.org/10.1021/ja00054a021research-articleACS PublicationsRequest reuse permissionsArticle Views1136Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct photoetching of polymer films using vacuum ultraviolet radiation generated by high-order anti-Stokes Raman scattering (1993)

High-order anti-Stokes Raman pulses of the vacuum ultraviolet were successfully utilized for ablation of polymer films. Efficient anti-Stokes conversion of the fourth harmonics of a conventional Nd:YAG laser provided fluences as large as 0.4 J/cm2 for a sixth-order anti-Stokes pulse at 160 nm. The selection of irradiation wavelength by a ready choice of scattered orders of Raman waves could verify critical wavelength dependence of ablation effect, which turned out that only the light at 160 nm made it possible to ablate polytetrafluoroethylene (PTFE) film with such low fluences.
Fast RTP Retransmission for IPTV - Implementation and Evaluation (2008)

With the deployment of IPTV reliability for multicast is becoming an important research topic again. Even though it has been intensively investigated before, there is now an understanding of the deployment scenario and the application requirements that allows solutions to be evaluated in detail. We describe how to design a fast retransmission cache based on recent extensions of RTP. We have implemented a prototype intended for deployment in an access node and explain the necessary trade-offs in the design. The paper also contains a performance evaluation which shows the efficiency of the retransmission functionality to handle losses and its performance in congested networks.
Alternative subgroup joint analysis proposal of nonlinear longitudinal and time-to-event data for modeling pregnancy miscarriage (2020)

Pregnancies achieved through in-vitro fertilization (IVF) are associated with adverse firsttrimester outcomes in comparison to spontaneously achieved pregnancies. Human chorionicgonadotrophin β subunit (β-HCG) is a well-known and accurate biomarker for the diagnosis and monitoring of pregnancy after IVF. Low levels of β-HCG during the first trimesterof pregnancy are related to miscarriage, ectopic pregnancy and failure of IVF procedure.Longitudinal profiles of β-HCG can be utilized to distinguish between normal and abnormalpregnancies, and to assist and guide the clinician in better management and monitoring ofpost-IVF pregnancies. Therefore, being able to assess the association between longitudinallymeasured β-HCG and time to early miscarriage is of crucial interest to clinicians. A commonjoint modeling approach proposal to achieve this objective is to use subject-specific randomeffects in a mixed effects model for longitudinal β-HCG data as predictors in a model for thetime-to-event (TTE) data. This work was motivated by an observational study with normaland abnormal pregnancies where serum concentrations of β-HCG were measured in 173young women during a gestational age of 9-86 days at a private clinic in Santiago, Chile.Some women experienced a miscarriage event but the rest did not. For those women whoexperienced miscarriage, their exact event times were unknown, in such case we have interval censored data, assuming that the event occurred between the last time of the observedβ-HCG measurement and ten days after. For our dataset we consider a nonlinear mixedeffects (NLME) model for both normal and abnormal pregnancies, but the joint model isconsidered only for the subgroup of miscarriage women. All the estimation procedures arebased on the Stochastic Approximation of the EM (SAEM) algorithm implemented in theMonolix software.
Extending High-Speed Operating Range of Induction Machine Drives Using Deadbeat-Direct Torque and Flux Control With Precise Flux Weakening (2019)

Flux weakening techniques have been developed for field-oriented control (FOC) drives to achieve the maximum torque capability above the base speed. Deadbeat-direct torque and flux control (DB-DTFC) has the advantages of precise torque and flux control and reduced parameter sensitivity compared to FOC, thus it has the benefit of more consistently achieving the maximum torque capability in the flux weakening region more accurately. This paper introduces a flux weakening strategy for DB-DTFC. Considering voltage and current limits, a simple solution to the optimal trajectory for the stator flux magnitude is derived to achieve the maximum feasible torque over the entire operating range. Results show that the speed control is extended to a significantly higher range beyond the base speed. Torque control is less sensitive to machine parameters and has better dynamics in the flux weakening region compared with the traditional FOC drives. Self-sensing is also investigated in the flux weakening region. Challenges of self-sensing are addressed to significantly extend the high-speed operating range.
Insights into physiological roles of unique metabolites released from Plasmodium-infected RBCs and their potential as clinical biomarkers for malaria (2019)

Plasmodium sp. are obligate intracellular parasites that derive most of their nutrients from their host meaning the metabolic circuitry of both are intricately linked. We employed untargeted, global mass spectrometry to identify metabolites present in the culture supernatants of P. falciparum-infected red blood cells synchronized at ring, trophozoite and schizont developmental stages. This revealed a temporal regulation in release of a distinct set of metabolites compared with supernatants of non-infected red blood cells. Of the distinct metabolites we identified pipecolic acid to be abundantly present in parasite lysate, infected red blood cells and infected culture supernatant. Further, we performed targeted metabolomics to quantify pipecolic acid concentrations in both the supernatants of red blood cells infected with P. falciparum, as well as in the plasma and infected RBCs of P. berghei-infected mice. Measurable and significant hyperpipecolatemia suggest that pipecolic acid has the potential to be a diagnostic marker for malaria.
Analysis of the Purcell effect in photonic and plasmonic crystals with losses (2010)

We study the spontaneous emission rate of emitter in a periodically patterned metal or dielectric membrane in the picture of a multimode field of damped Bloch states. For Bloch states in dielectric structures, the approach fully describes the Purcell effect in photonic crystal or spatially coupled cavities with losses. For a metal membrane, the Purcell factor depends on resistive loss at the resonant frequency of surface plasmon polariton (SPP). Analysis of an InP-Au-InP structure indicates that the SPP's Purcell effect can exceed a value of 50 in the ultraviolet. For a plasmonic crystal, we find a position-dependent Purcell enhancement with a mean value similar to the unpatterned membrane.
Stichwortverzeichnis (2020)

Veränderungen sind im Zuge der Digitalisierung an der Tagesordnung - doch tauchen dabei immer wieder Barrieren auf. Dies macht es den Verantwortlichen oft sehr schwer, den anstehenden Wandel im notwendigen Umfang und in einer angemessenen Zeit umzusetzen.
Age‐associated Memory Impairment: Assessing the Role of Nitric Oxide (1998)

Several neurotransmitter systems have been investigated to assess hypothesized mechanisms underlying the decline in recent memory abilities in normal aging and in Alzheimer's disease. Examining the performance of F344 rats in a 14-unit T-maze (Stone maze), we have focused on the muscarinic cholinergic (mACh) and the N-methyl-D-aspartate (NMDA) glutamate (Glu) systems and their interactions. Maze learning is impaired by antagonists to mACh or NMDA receptors. We have also shown that stimulation of mACh receptors can overcome a maze learning deficit induced by NMDA blockade, and stimulation of the NMDA receptor can overcome a similar blockade of mACh receptors. No consistent evidence in rats has been produced from our laboratory to reveal significant age-related declines in mACh or NMDA receptor binding in the hippocampus (HC), a brain region that is greatly involved in processing of recent memory. Thus, we have directed attention to the possibility of a common signal transduction pathway, the nitric oxide (NO) system. Activated by calcium influx through the NMDA receptor, NO is hypothesized to be a retrograde messenger that enhances presynaptic Glu release. Maze learning can be impaired by inhibiting the synthetic enzyme for NO, nitric oxide synthase (NOS), or enhanced by stimulating NO release. However, we have found no age-related loss of NOS-containing HC neurons or fibers in rats. Additionally, other laboratories have reported no evidence of an age-related loss of HC NOS activity. In a microdialysis study we have found preliminary evidence of reduced NO production following NMDA stimulation. We are currently working to identify the parameters of this phenomenon as well as testing various strategies for safely stimulating the NO system to improve memory function in aged rats.
Impact of pre-concentration to covalently biofunctionalize suspended nanoparticles (2010)

The effective biofunctionalization of nanoparticles is crucial for biomedical applications. In this study we investigated the covalent biofunctionalization of magnetic nanoparticles based on carbodiimide activation. An important aspect in the covalent biofunctionalization of nanoparticles has been neglected, namely pre-concentration. Exploiting the electrostatic attraction forces between a protein and the nanoparticle surface will favor the covalent immobilization. We showed that low ionic strength buffers with a pH slightly lower than the pI of the selected biomolecules is needed to increase the yield of covalent immobilization. Additionally, it is demonstrated that the covalently immobilized proteins are bioactive, relying on a sandwich assay using gold nanoparticles as reporter labels.
Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003)

Developmental dyslexia, characterized by unexplained difficulty in reading, is associated with behavioral deficits in phonological processing. Functional neuroimaging studies have shown a deficit in the neural mechanisms underlying phonological processing in children and adults with dyslexia. The present study examined whether behavioral remediation ameliorates these dysfunctional neural mechanisms in children with dyslexia. Functional MRI was performed on 20 children with dyslexia (8-12 years old) during phonological processing before and after a remediation program focused on auditory processing and oral language training. Behaviorally, training improved oral language and reading performance. Physiologically, children with dyslexia showed increased activity in multiple brain areas. Increases occurred in left temporo-parietal cortex and left inferior frontal gyrus, bringing brain activation in these regions closer to that seen in normal-reading children. Increased activity was observed also in right-hemisphere frontal and temporal regions and in the anterior cingulate gyrus. Children with dyslexia showed a correlation between the magnitude of increased activation in left temporo-parietal cortex and improvement in oral language ability. These results suggest that a partial remediation of language-processing deficits, resulting in improved reading, ameliorates disrupted function in brain regions associated with phonological processing and produces additional compensatory activation in other brain regions.
Partial Element Equivalent Circuit models in the solution of the electric field integral equation (2012)

3-D electromagnetic methods are fundamental design tools for complex high-speed systems. Among the integral equation-based techniques, the Partial Element Equivalent Circuit (PEEC) method has received a special attention in interconnect modeling, where mixed electromagnetic/circuit problems need to be solved. Retardation effects and the resulting delays must be taken into account and included in the modeling, when signal waveform rise times decrease and the corresponding frequency content increases or the geometric dimensions become electrically long. In this case, the enforcement of the Kirchhoff laws to PEEC delayed models leads to a set of delayed differential equations in a neutral form. The aim of this contribution is to present an overview of the PEEC method with special focus on the analysis of electrically long structures that require taking delays into account.
The Retracing Boomerang Attack. (2019)

Boomerang attacks are extensions of differential attacks, that make it possible to combine two unrelated differential properties of the first and second part of a cryptosystem with probabilities p and q into a new differential-like property of the whole cryptosystem with probability \(p^2q^2\) (since each one of the properties has to be satisfied twice). In this paper we describe a new version of boomerang attacks which uses the counterintuitive idea of throwing out most of the data in order to force equalities between certain values on the ciphertext side. In certain cases, this creates a correlation between the four probabilistic events, which increases the probability of the combined property to \(p^2q\) and increases the signal to noise ratio of the resultant distinguisher. We call this variant a retracing boomerang attack since we make sure that the boomerang we throw follows the same path on its forward and backward directions. To demonstrate the power of the new technique, we apply it to the case of 5-round AES. This version of AES was repeatedly attacked by a large variety of techniques, but for twenty years its complexity had remained stuck at \(2^{32}\). At Crypto’18 it was finally reduced to \(2^{24}\) (for full key recovery), and with our new technique we can further reduce the complexity of full key recovery to the surprisingly low value of \(2^{16.5}\) (i.e., only 90, 000 encryption/decryption operations are required for a full key recovery on half the rounds of AES).
Rectified diffusion at megahertz frequencies (1981)

Rectified diffusion studies have in the past been generally confined to kilohertz frequency ranges where experimental confirmation of theoretical predictions can be made. However, since most of the ultrasonic devices used in medicine operate in the megahertz frequency range, it is important to extend these studies of the growth of bubbles by ultrasound to the higher range. We have modified and extended the equations associated with rectified diffusion to apply at megahertz frequencies, and have numerically solved these equations for a variety of conditions such as dissolved gas concentration, distribution of nuclei, and the frequency and intensity of the ultrasound. We have also obtained solutions for both the continuous and pulsed modes of operation. Our results indicate that bubbles can be made to grow at typical levels of exposure used in medical applications. Furthermore, at higher intensities, such as those used in studies on bean roots by Morris and Coakley [to be published in Ultrasound Med. Biol.], the times required for growth to resonance size are on the same order of magnitude as the periods associated with acoustic emissions from the root during insonification. [Work partially supported by the Office of Naval Research and the National Science Foundation.]
Regulation of intermittent oscillatory activity of pyramidal cell neurons by GABA inhibitory interneurons is impaired in schizophrenia: rationale for pharmacotherapeutic GABAergic interventions. (2010)

GABA, the major inhibitory neurotransmitter in the brain, is synthesized from L-glutamate and packaged within a family of highly differentiated inhibitory interneurons. Individual GABA inhibitory interneurons in the frontal cortex can make terminal synaptic connections with more than 200 distinct pyramidal neurons, the principal output neuron. Moreover, the sites of these synaptic connections include shafts of dendritic spines, soma, dendritic branches, and initial axon segments. The phasic activity of GABAergic neurons regulate intermittent oscillations of assemblies of pyramidal cell neurons, which are critical for many higher cortical functions such as working memory. Potentially, there are several viable pharmacotherapeutic strategies for facilitating GABAergic neurotransmission. A major research question is whether tonically-administered, selective GABAergic therapeutic interventions can mimic and correct disruptions of the intermittent oscillatory activity of assemblies of cortical pyramidal cell neurons.
Wafer-Level Packaging Technology for High-&lt;tex&gt;$Q$&lt;/tex&gt;On-Chip Inductors and Transmission Lines (2004)

In the current trend toward portable applications, high-Q integrated inductors have gained considerable importance. Hence, much effort has been spent to increase the performance of on-chip Si inductors. In this paper, wafer-level packaging (WLP) techniques have been used to integrate state-of-the-art high-Q on-chip inductors on top of a five-levels-of-metal Cu damascene back-end of line (BEOL) silicon process using 20-/spl Omega//spl middot/cm Si wafers. The inductors are realized above passivation using thick post-processed low-K dielectric benzocyclobutene (BCB) and Cu layers. For a BCB-Cu thickness of 16 /spl mu/m/10 /spl mu/m, a peak single-ended Q factor of 38 at 4.7 GHz has been measured for a 1-nH inductor with a resonance frequency of 28 GHz. Removing substrate contacts slightly increases the performance, though a more significant improvement has been obtained by combining post-processed passives with patterned ground shields: for a 2.3-nH above integrated-circuit (above-IC) inductor, a 115% increase in Q/sub BW//sup max/ (37.5 versus 17.5) and a 192% increase in resonance frequency (F/sub res/: 12 GHz versus 5 GHz) have been obtained as compared to the equivalent BEOL realization with a patterned ground shield. Next to inductors, high-quality on-chip transmission lines may be realized in the WLP layers. Losses below -0.2 dB/mm at 25 GHz have been measured for 50-/spl Omega/ post-processed coplanar-waveguide lines, above-IC thin-film microstrip lines have measured losses below -0.12 dB/mm at 25 GHz.