gebhart/patrepeval huggingface dataset:
An Energy-Saving and Cost-Reduction Bandwidth Monitoring Model Using PRTG Monitoring Software (2023)

A significant feature of bandwidth monitoring structure is the excellent delivery of internet facilities with larger data rates and bigger coverage. Existing research on bandwidth monitoring focused on pattern tracking, health monitoring, and the performance of numerous physical communication interfaces, amongst others. However, these researches were not Energysaving and cost-reduction in reducing the overhead energy cost of bandwidth monitoring by which internet users achieve their goals to the background. This research was aimed at developing an Energy-saving and costreduction bandwidth monitoring model. These techniques had two stages which are network traffic observation and Bandwidth consumption analysis stages of bandwidth monitoring. Data collection for this research based on bandwidth monitoring using the Paessler Router Traffic Grapher (PRTG) network monitoring software was done at a network operating centre in South-Western Nigeria. The data collected comprised 8,673 records of bandwidth monitored metrics such as Date/Time of bandwidth monitoring, Network traffic volume (of end-to-end connectivity), Network traffic speed (from source to destination and vice-versa), Network downtime, and coverage. The model was formulated using bandwidth optimization (BO) techniques while the data collected were coupled with three algorithms: FUE-sub-channel matching algorithm (FSMA), Joint sub-channel and power allocations algorithm (JSPA), and integrated structure cabling system algorithm (ISCSA). The proposed algorithm was used to formulate the monitoring model using the PRTG monitoring tool. A new mathematical equation was formulated from the model for the integration of Anti-Meridian (AM) / PrimeMeridian (PM) Timer relays and the Normally-Open (NO)/Normally-closed (NC) switches for Energy-saving and cost-reduction to design the monitoring model. When the existing algorithms were compared to the proposed bandwidth monitoring model, the proposed model generated a higher success rate with a maximum of 50 wireless routers capacity.
Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection (2003)

The combination of antiviral drugs and IL-2 induced a greater expansion and function of CD4 T cells than antiretroviral drugs alone.
Measurement of Three-Dimensional Radiation Dose Distributions Using MRI (1991)

Recent investigations have shown that nuclear magnetic resonance (NMR) can be used in conjunction with a suitable chemical dosimeter to estimate the dose from ionizing radiation (Gore et al., Phys Med. Biol. 29, 1189-1197, 1984). Based on this fact it was proposed that spatial dose distributions can be measured in gels infused with the chemical dosimeter using NMR imaging. There have been few such attempts and they provided only qualitative results. In this paper, we report results demonstrating the feasibility of obtaining quantitative dose distribution measurements by this technique. It is shown that quantitative dose distribution measurements necessitate the calculation of relaxation rate maps. We have determined that the spin-spin relaxation rate is a more sensitive parameter than the spin-lattice relaxation rate. It is also demonstrated that the addition of chemical sensitizers could improve the dose sensitivity of the measured NMR parameters. The two features characterizing a photon beam, depth-dose relationship, and beam profile as measured by this technique are in good agreement with the measurements using conventional methods, ionization chambers, and film dosimetry.
Response to Cardiac Resynchronization Therapy Predicts Survival in Heart Failure: A Single‐Center Experience (2007)

Patients who experience improved symptoms, ventricular function, and/or hemodynamics have better survival after CRT. These data enhance understanding of the relationship between CRT clinical response and survival benefit in clinical practice.
Stable Carbon Isotopic Evidence for Maize Agriculture in Southeast Missouri and Northeast Arkansas (1986)

Analysis of bone collagen extracted from human skeletal remains from archaeological sites dating from the Archaic period through Euro-American settlement provides evidence for the introduction of maize into regional subsistence patterns. Stable carbon isotope ratios of samples from both the eastern Ozarks and the Mississippi River alluvial valley indicate that human populations living prior to ca. A.D. 1000 consumed little or no C4 plant material. In populations dating after ca. A.D. 1000, stable carbon isotope ratios indicate that maize represented a significant part of the human diet throughout the region. The change in dietary patterns coincides with a shift in settlement patterns from dispersed hamlets and small villages to civic-ceremonial centers with associated villages, hamlets, and farmsteads. This isotopic evidence indicates that Emergent Mississippian diets did not include substantial quantities of maize or other C4 plant material.
Super-resolution Mapping of Flow Velocity Distribution in Nanofluidic Channels (2006)

We will show a super-resolution mapping technique for measuring the flow velocity distribution in nanofluidic channels. The mapping resolution can be much smaller than the diffraction limit of the optical imaging system.
Structural Characterization of a Guanine−Quadruplex Ligand Complex (2000)

The inhibition of telomerase by molecules such as disubstituted amidoanthraquinones is believed to be due to their stabilization of guanine-quadruplex complexes. The characterization is reported of a complex with the intermolecular parallel quadruplex formed from the sequence TGGGGT and a 1,4-bis-piperidino amidoanthraquinone. Crystals obtained did not give single-crystal diffraction; the fiber-like pattern has been interpreted in terms of a repeating unit with four guanine-quartets and two stacked/intercalated ligand molecules. The two categories of possible structures for the complex consistent with this interpretation have been examined by molecular dynamics simulations, with fully solvated environments and 1000 ps simulation times. The two central guanine-quartets in the intercalation model rapidly became highly distorted, whereas the two types of models with ligand stacked externally on the ends of the quadruplex remained very stable. It was concluded that the externally bound ligand complexes best represent the structure of this quadruplex complex, in agreement with earlier NMR results on related systems.
Effects of Impurities on Fuel Cell Performance and Durability (Final Report) (2011)

This program is focused on the experimental determination of the effects of key hydrogen side impurities on the performance of PEM fuel cells. Experimental data has been leveraged to create mathematical models that predict the performance of PEM fuel cells that are exposed to specific impurity streams. These models are validated through laboratory experimentation and utilized to develop novel technologies for mitigating the effects of contamination on fuel cell performance. Results are publicly disseminated through papers, conference presentations, and other means.
TaqMan ® -Based Quantification of Invasive Cells in the Chick Embryo Metastasis assay (2004)

The chick embryonic metastasis (CEM) assay is a fast in vivo method to investigate the invasive properties of tumor cells. Until now, most quantification methods were semiquantitative and time-consuming. Here we describe a rapid quantification method using TaqMan technology to quantify the invaded tumor cells in the chorioallantoic membrane of fertilized eggs. This method is based on specific detection of human ALU sequences. Moreover, it provides high sensitivity over a wide linearity range.
Fabrication of spherical mitigation pit on KH_2PO_4 crystal by micro-milling and modeling of its induced light intensification (2013)

Micro-machining is the most promising method for KH(2)PO(4) crystal to mitigate the surface damage growth in high power laser system. In this work, spherical mitigation pit is fabricated by micro-milling with an efficient machining procedure. The light intensification caused by rear surface features before and after mitigation is numerically modeled based on the finite-difference time-domain method. The results indicate that the occurrence of total internal reflections should be responsible for the largest light intensification inside the crystal. For spherical pits after mitigation, the light intensification can be greatly alleviated by preventing the occurrence of total internal reflections. The light intensification caused by spherical mitigation pit is strongly dependent on the width-depth ratio and it is suggested that the width-depth ratio of spherical mitigation pit must be devised to be larger than 5.0 to achieve the minimal light intensification for the mitigation of surface damage growth. Laser damage tests for KH(2)PO(4) crystal validate that the laser damage resistance of initially damaged surface can be retrieved to near the level of ideal surface by replacing initial damage site with predesigned mitigation pit.
IRF3 inhibits IFNγ-mediated restriction of intracellular pathogens in macrophages independently of type I interferons (2018)

Abstract Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antimicrobial responses. In addition, extrinsic activation with the cytokine interferon gamma (IFNγ) is often required as well to tip the scales of the host-pathogen balance toward pathogen restriction. However, little is known about how host pathogen sensing impacts the anti-microbial IFNγ-activated state. We observed that in the absence of IRF3, a key downstream component of pathogen sensing pathways, IFNγ-primed macrophages more efficiently restricted the intracellular bacterium Legionella pneumophila and the intracellular protozoan parasite Trypanosoma cruzi. This effect was not mediated by Type I interferons, the key cytokines known to be induced by IRF3, or by the sensing adaptors MyD88/TRIF, MAVS, and STING. However, IRF3-deficient macrophages displayed a significantly altered IFNγ-induced gene expression program, with upregulation of microbial restriction factors such as Nos2. Furthermore, Nos2 activity was required for the enhanced IFNγ-mediated restriction of T. cruzi observed in IRF3-deficient macrophages. Finally, we found that IFNγ-primed but not resting macrophages largely excluded the activated form of IRF3 from the nucleus. These data are consistent with a relationship of mutual inhibition between IRF3 and IFNγ-activated programs, possibly as a component of a partially reversible mechanism for modulating the activity of potent innate immune effectors such as Nos2 in the context of intracellular infection.
Utilization of Renewable Carbon in Electric Arc Furnace-Based Steel Production: Comparative Evaluation of Properties of Conventional and Non-Conventional Carbon-Bearing Sources (2023)

Conventional (anthracite, calcined petroleum coke, and coke) and non-conventional (biochar, and biocokes (3 wt.% torrefied wood, and 3 wt.% petroleum coke + 3 wt.% charcoal)) carbon-bearing sources have been studied for their use in electric arc furnace (EAF)-based steel production. Commonly, for the use of carbon sources in EAFs, one of the important properties is the content of fixed carbon, the release of volatiles as well as the elemental composition of inorganics. The properties of six carbon sources were analyzed by determining the proximate analysis, X-ray fluorescence analysis (XRF), coke reactivity index (CRI), and strength after reaction with CO2 (CSR), Brunauer–Emmett–Teller (BET) specific surface area and Barrett–Joyner–Halenda (BJH) pore size and volume analysis, ash chemical analysis, optical and scanning microscopy, Raman spectroscopy and X-ray diffraction (XRD) analysis. The results indicate biocoke as a promising option to replace conventional carbon-bearing sources. In the sample set, the fixed carbon, volatiles, and ash content of the biocokes were similar despite the total difference in additives. Additionally, the use of additives did not significantly affect the biocoke reactivity indices, but slightly decreased the strength after the reaction with CO2. Carbon-bearing sources have been characterized in terms of their structural properties. XRD analysis revealed that the amount of disordered carbon increased in the order: coke &lt; calcined petroleum coke ~ biocoke (3 wt.% torrefied wood) &lt; biocoke (3 wt.% petroleum coke + 3 wt.% charcoal) &lt; biochar. The results obtained on the physical, chemical, and structural properties of carbon sources are the basis for further research on the behavior of slag foaming.
Fluorescence Adherence Inhibition Assay: A Novel Functional Assessment of Blocking Virus Attachment by Vaccine-Induced Antibodies (2016)

&lt;div&gt;&lt;p&gt;Neutralizing antibodies induced by vaccination or natural infection play a critically important role in protection against the viral diseases. In general, neutralization of the viral infection occurs via two major pathways: pre- and post-attachment modes, the first being the most important for such infections as influenza and polio, the latter being significant for filoviruses. Neutralizing capacity of antibodies is typically evaluated by virus neutralization assays that assess reduction of viral infectivity to the target cells in the presence of functional antibodies. Plaque reduction neutralization test, microneutralization and immunofluorescent assays are often used as gold standard virus neutralization assays. However, these methods are associated with several important prerequisites such as use of live virus requiring safety precautions, tedious evaluation procedure and long assessment time. Hence, there is a need for a robust, inexpensive high throughput functional assay that can be performed rapidly using inactivated virus, without extensive safety precautions. Herein, we report a novel high throughput Fluorescence Adherence Inhibition assay (fADI) using inactivated virus labeled with fluorescent secondary antibodies virus and Vero cells or erythrocytes as targets. It requires only few hours to assess pre-attachment neutralizing capacity of donor sera. fADI assay was tested successfully on donors immunized with polio, yellow fever and influenza vaccines. To further simplify and improve the throughput of the assay, we have developed a mathematical approach for calculating the 50% titers from a single sample dilution, without the need to analyze multi-point titration curves. Assessment of pre- and post-vaccination human sera from subjects immunized with IPOL&lt;sup&gt;®&lt;/sup&gt;, YF-VAX&lt;sup&gt;®&lt;/sup&gt; and 2013–2014 Fluzone&lt;sup&gt;®&lt;/sup&gt; vaccines demonstrated high efficiency of the assay. The results correlated very well with microneutralization assay performed independently by the FDA Center of Biologics Evaluation and Research, with plaque reduction neutralization test performed by Focus Diagnostics, and with hemaglutination inhibition assay performed in-house at Sanofi Pasteur. Taken together, fADI assay appears to be a useful high throughput functional immunoassay for assessment of antibody-related neutralization of the viral infections for which pre-attachment neutralization pathway is predominant, such as polio, influenza, yellow fever and dengue.&lt;/p&gt;&lt;/div&gt;
Testosterone Is Not Required for The Maintenance of Muscle Mass in Fully Matured and Elderly Male Mice (2019)

Testosterone (T), the main androgenic hormone, is assumed to play an important role in the maintenance of skeletal muscle mass and function through its effects on satellite cell proliferation and differentiation, as well as its activation of pathways downstream of the IGF‐1 receptor and AKT. T depletion through chemical castration as a treatment for prostate cancer and the use of T to treat sarcopenia are both common practices in older humans, yet the majority of animal studies aimed at elucidating T's role in the maintenance of skeletal muscle mass are performed in young rodents under the age of 3 months. In addition, the role of T's activity in skeletal muscle health remains equivocal, with some studies showing circulating T to have great importance, while others suggest a limited or non‐significant role. Hence, the aim of this project was to characterize the phenotypic outcome of T depletion on skeletal muscle across lifespan and identify the contributing molecular pathways. To elucidate T's role on skeletal muscle throughout life, C57Bl/6 male mice were castrated at 4 different ages (1.5, 5, 12, or 24 months) and returned to normal cage activity for one month before muscle mass, protein synthesis and degradation, mTORC activity, and fiber cross sectional area were analyzed. Consistent with current literature, skeletal muscle mass reached a peak at 6 months before progressively declining (11.4% and 23.1% in the TA and gastrocnemius muscles, respectively) by 25‐months of age. In young animals, the removal of circulating T resulted in a decrease of the TA muscle mass (12.2% and 16.7% in the 1.5‐ and 5‐month old groups, respectively). Castration also slowed the growth of the gastrocnemius muscle with the 1.5‐ and 5‐month groups presenting muscles that are 9.4% and 11.6% smaller, respectively. Conversely, T depletion had no effect on muscle mass in the 12 months and 24 months groups. The decrease in cross sectional area in the absence of T in the young groups was similar to the decrease in muscle mass. Statistical analysis revealed a stronger interaction between age and treatment in the TA (P = 0.011) compared to the Gastrocnemius (P = 0.24). Together these data suggest that in skeletally immature animals, circulating T plays an important role in the regulation of muscle mass. In contrast, once muscle mass peaks and begins to decline naturally, circulating T no longer appears to affect muscle mass. Since T primarily affects skeletal maturation, it is essential that age appropriate animals are used when determining the role of T on skeletal muscle function. Specifically, studies on the anabolic effects of T need to use C57Bl/6 mice that are older than 6 months in order to translate to humans. Support or Funding Information UC Davis Clinical and Translational Science Center UC Davis Office of Graduate Studies This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Angular Distribution of Photoelectrons (1968)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Cooper, R. N. Zare; Angular Distribution of Photoelectrons. J. Chem. Phys. 15 January 1968; 48 (2): 942–943. https://doi.org/10.1063/1.1668742 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Measurement of the forward Z boson production cross-section in pp collisions at s = 13 $$ \sqrt{s}=13 $$ TeV (2016)

A measurement of the production cross-section of Z bosons in pp collisions at s = 13 TeV is presented using dimuon and dielectron final states in LHCb data. The cross-section is measured for leptons with pseudorapidities in the range 2.04.5, transverse momenta p T 20 GeV and dilepton invariant mass in the range 60m()120 GeV. The integrated cross-section from averaging the two final states is
Small-size lung nodule modeling and detection with clinical evaluation (2012)

In this paper examination of the template modeling process using the Active Appearance Modeling (AAM) approach for automatic detection of lung nodules is investigated. A template matching approach is formulated to compute a similarity score between the AAM templates and the input lung CT slice, where the goal is to maximize the similarity measure at different image pixels to increase nodule detection. The template matching approach is implemented using nine similarity measures. Performance validation for the robustness of the generated models is tested on three clinical databases.
Brain endothelial cell specific integrins and ischemic stroke (2014)

Ischemic stroke, a devastating event caused by the blockage of a blood vessel(s) supplying the brain, continues to affect thousands of people in the USA every year. While no true advances in stroke therapy have arisen to further improve patient outcomes since the introduction of the blood clot buster tissue plasminogen activator and mechanical clot removal, fewer people are dying from the immediate stroke insult. Instead, patients often suffer significant morbidity due to post-recanalization secondary damage. Central to this damage is the breakdown of the blood-brain barrier, which, in addition to contributing to edema and inflammation, triggers an upregulation in angiogenic growth factors in the brain's attempt to salvage and repair itself. Recent studies have begun to improve our understanding of the post-stroke angiogenic response of brain endothelial cells in the ischemic penumbra, which has long been held to be an important site for medical intervention. These studies suggest that endothelial cell integrin matrix receptors play an important and therapeutically significant role in moderating cellular responses to ischemic brain injury.
Endothelins Induce CCR7 Expression by Breast Tumor Cells via Endothelin Receptor A and Hypoxia-Inducible Factor-1 (2006)

Endothelin expression is increased in breast tumors and is associated with invasion and metastasis, whereas CCR7 expression by breast tumor cells may have a role in the organ specificity of breast cancer spread. In this article, we have analyzed whether endothelins influence breast tumor cell expression of the chemokine receptor CCR7. Stimulation of human breast tumor cell lines with endothelins increased cell surface expression of CCR7 via endothelin receptor A. The iron chelators desferrioxamine and cobalt chloride, which induce hypoxia-inducible factor (HIF)-mediated transcription, also increased CCR7 expression; transfection of a dominant-negative version of the HIF regulatory subunit, HIF-1alpha, into MCF-7 cells abolished CCR7 induction by endothelins, indicating that increased expression is due to HIF-1 stabilization. Endothelin stimulation promoted invasion toward the CCR7 ligands CCL19 and CCL21. Endothelin-mediated chemokine-independent invasion itself is dependent on CCR7 activity and could be abolished using a CCR7-neutralizing monoclonal antibody. In human breast carcinomas, mRNA expression of endothelins correlated with the level of CCR7 expression, both of which were associated with the presence of lymph node metastases. Expression of the CCR7 ligands CCL19 and CCL21 was also higher in breast cancer patients with lymph node involvement compared with those without, but expression of these chemokines did not correlate with endothelin expression. These data show that CCR7 may be regulated by the breast tumor microenvironment and further support the use of endothelin receptor antagonists in the treatment of invasive and metastatic breast cancer.