gebhart/patrepeval huggingface dataset:
Epidemiology of Diabetic Foot Ulcers and Amputations in Romania: Results of a Cross-Sectional Quality of Life Questionnaire Based Survey (2016)

This is a post hoc analysis of quality of life in diabetic neuropathy patients in a cross-sectional survey performed in 2012 in Romania, using the Norfolk QOL-DN in which 21,756 patients with self-reported diabetes were enrolled. This current analysis aims to expand research on the diabetic foot and to provide an update on the number of foot ulcers found in Romania. Of the 21,174 patients included in this analysis, 14.85% reported a history of foot ulcers and 3.60% reported an amputation. The percentage of neuropathy patients with foot ulcers increased with age; the lowest percentage was observed in the 20-29-year age group (6.62%) and the highest in the 80-89-year age group (17.68%). The highest number of amputations was reported in the 70-79-year age group (largest group). Compared to patients without foot ulcers, those with foot ulcers had significantly higher scores for total DN and all its subdomains translating to worse QOL (p < 0.001). This analysis showed a high rate of foot ulcers and amputations in Romanian diabetic patients. It underscores the need for implementation of effective screening and educational programs.
DOP026 Efficacy and safety of dose escalation to tofacitinib 10 mg BID for patients with ulcerative colitis following loss of response on tofacitinib 5 mg BID maintenance therapy: results from OCTAVE open (2018)

Tofacitinib is an oral, small-molecule Janus kinase inhibitor that is being investigated for ulcerative colitis (UC). We evaluated efficacy and safety of tofacitinib dose escalation in patients with UC participating in an ongoing, open-label, long-term extension (LTE) study (OCTAVE Open, NCT01470612; data as of July 2016 [efficacy], December 2016 [safety]). OCTAVE1 included induction (OCTAVE Induction 1 and 2), maintenance (OCTAVE Sustain) and LTE (OCTAVE Open) studies. OCTAVE Open included non-responders from OCTAVE Induction 1 and 2 and patients who completed or experienced treatment failure in OCTAVE Sustain. This analysis included the subpopulation of patients in OCTAVE Open who achieved clinical response following 8 weeks of induction therapy with tofacitinib 10 mg twice daily (BID), entered OCTAVE Sustain receiving tofacitinib 5 mg BID and experienced treatment failure between Week 8 and up to Week 52, and subsequently entered OCTAVE Open and were escalated to tofacitinib 10 mg BID. Treatment failure was defined as increase ≥3 points from maintenance study baseline total Mayo score, plus increase in rectal bleeding subscore and endoscopic subscore (ES) ≥1 point and absolute ES ≥2 after ≥8 weeks of maintenance therapy. We evaluated clinical response, mucosal healing and remission at Months 2 and 12 of OCTAVE Open using non-responder imputation, and evaluated safety throughout the study. The dose escalation subpopulation comprised 58 patients in OCTAVE Open (out of 914 enrolled in the study). In patients escalated to tofacitinib 10 mg BID, clinical response, mucosal healing and remission rates were, respectively, 58.6%, 41.4% and 34.5% at Month 2, and 68.8%, 60.4% and 52.1% at Month 12 (Table). The safety profile of tofacitinib 10 mg BID in the dose escalation subpopulation was generally consistent with that observed in the overall study population (Table).2 For patients who lost initial clinical response to tofacitinib 10 mg BID induction therapy while on tofacitinib 5 mg BID maintenance therapy, dose escalation back to 10 mg BID recaptured clinical response for most patients by Month 2, and was well-tolerated, with no new safety signals. Interpretation of adverse event rates is limited due to the small sample size. 1. Sandborn WJ, et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med, 2017;376:1723–36. 2. Lichtenstein GR, et al. Tofacitinib, an oral Janus kinase inhibitor, in the treatment of ulcerative colitis: open-label, long-term extension study. Am J Gastroenterol, 2017;112(S1) [Abstract 714].
Low Prevalence of Avian Influenza Virus in Shorebirds on the Pacific Coast of North America (2008)

The emergence of highly pathogenic avian influenza (HPAI) H5N1 has elevated concerns about wild birds as virus hosts; however, little is known about the ecological and epidemiological factors of transmission by shorebirds. Here we summarize results for 2,773 shorebirds that were live-trapped on the Pacific coast of the United States during 2006-2007 and tested for avian influenza virus using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and virus isolation. As was the case throughout North America, HPAI H5N1 was not detected in shorebirds during this interval. Contrary to other wild bird groups, most notably waterfowl, the prevalence of even low pathogenicity virus among shorebirds in our study areas in California, Washington, and Alaska was extremely low (0.5%). Virus was detected by RT-PCR from four different species, including, Dunlin (Calidris alpina; N = 3), Western Sandpiper (C. mauri; N = 8), Long-billed Dowitcher (Limnodromus scolopaceus; N = 1), and American Avocet (Recurvirostra americana; N = 1), with the detections in the latter three constituting the first published records for these birds. Based on studies in the eastern United States, we expected, but did not detect (H1 = 1.6, P = 0.21) elevated avian influenza prevalence among shorebirds during spring migration. Diagnostic tests, which were designed to evaluate testing and sampling methods, indicated poor functioning of traditional virus isolation methods and no improvement in detection likelihood by collecting oropharyngeal swabs in addition to cloacal swab samples for low pathogenicity viruses (Z1 = 0.7, P = 0.48).
Der p 23‐specific IgE response throughout childhood and its association with allergic disease: A birth cohort study (2022)

Der p 23 sensitisation peaks in late childhood and then decreases. It is preceded by early mite exposure and AD. Asthma and AR can occur in patients persistently sensitised to Der p 23 as the only mite allergen, suggesting the inclusion of molecular testing of Der p 23-sIgE for subjects with clinical suspicion of HDM allergy but without sIgE to other major D.pt. allergens.
CELTIC CP5-026 WINNER+, D2.1 Preliminary WINNER+ System Concept (2009)

This deliverable provides an overview of the WINNER+ system concept which encompasses the following innovations areas for IMT-Advanced technologies: advanced RRM, spectrum technologies, advanced co-located antennas and coordinated multipoint systems. The concepts of each of these areas are described thoroughly. These concepts are composed of techniques and methods that were identified out of a wider set.
Technique Using Isoelastic Tension Band for Treatment of Olecranon Fractures. (2015)

The isoelastic ultrahigh-molecular-weight polyethylene tension band may be considered an alternative to stainless steel wire for tension band fixation of olecranon fractures. In this article, we present our technique using this isoelastic tension band and describe the outcomes of 7 patients who underwent open reduction and internal fixation of closed, displaced olecranon fractures with minimal or no articular surface comminution. We reviewed medical records and performed physical examinations and functional assessments. Anatomical reduction was maintained in all elbows through union. Physical examination measurements indicated nominal side-to-side differences in motion and strength. Mean Broberg and Morrey elbow score was good (92/100), and mean (SD) Disabilities of the Arm, Shoulder, and Hand score was 12.6 (17.2). One patient had a minor degree of hardware irritation at longest follow-up but did not request hardware removal. One patient underwent implant removal for a symptomatic implant 5 years after surgery. This easily reproducible technique yields excellent physical and functional outcomes.
Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages (2002)

Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, affecting approximately 2% of the world's population. The immune mechanisms responsible for the highly variable natural history in a given individual are unknown. We used a multiparameter flow cytometric technique to functionally and phenotypically characterize HCV-specific effector T cells in the peripheral blood of 32 individuals with different stages of hepatitis C disease (resolved, mild chronic, advanced chronic) and normal controls. We found the highest frequencies of virus-specific effector cells with an activated memory phenotype (CD45RO+CD69+) in subjects who had resolved HCV infection, either spontaneously or with antiviral therapy. Effector cells from patients with resolved infection produced Th1 type cytokines following stimulation with nonstructural antigens (NS3 and NS4), whereas effector cells from chronically infected patients produced Th1 type cytokines predominantly following stimulation with the HCV core antigen. Stimulation with superantigen staphylococcal enterotoxin (SEB) induced the same levels of cytokine production in the different patient groups. Among the HCV-seropositive patients, viral load inversely correlated with the Th1 effector cell response to NS3. Interleukin (IL)-4 was produced only in response to the control antigens, but not in response to the HCV recombinant proteins. Taken together, these findings suggest that a vigorous HCV-specific CD4+ Th1 response, particularly against the nonstructural proteins of the virus, may be associated with viral clearance and protection from disease progression. Prospective studies using this new flow cytometric assay will be required to determine whether antiviral therapy modifies the frequency, specificity, and function of these virus-specific effector cells.
ChemInform Abstract: Solution Phase Preparation of Highly Pure Amide Mixtures via in situ Chlorotrimethylsilane Protection and Activation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optical surface microscopy with a moving microsphere (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Sumetsky, Y. Dulashko, and D. J. DiGiovanni, "Optical surface microscopy with a moving microsphere," in Integrated Photonics Research and Applications/Nanophotonics, Technical Digest (CD) (Optica Publishing Group, 2006), paper NThD3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Cooperative communications with partial channel state information: When to cooperate? (2005)

In this paper we propose a new cooperative protocol, which takes into consideration the partial channel state information (CSI) available at the source. With such protocol a significant improvement in the transmission rate can be achieved in decode-and-forward cooperative transmission, while guaranteeing full diversity order. We derive closed-form expressions for the transmission rate and the symbol error rate (SER) for the M-PSK and the M-QAM signalling. Moreover, we consider two optimization metrics in the protocol design to enhance the system performance; the first is based on minimizing the SER only, while the second is based on minimizing a joint function of both the SER and the transmission rate. Finally, the obtained analytical results are verified through computer simulations
Coherently Coupled Photonic-Crystal Surface-Emitting Laser Array (2015)

The realization of a 1 × 2 coherently coupled photonic crystal surface emitting laser array is reported. New routes to power scaling are discussed and the electronic control of coherence is demonstrated.
An Asymmetric Synthesis Protocol to Prepare Topographically Constrained β-Substituted Aromatic Amino Acids (2003)

The side chain groups of amino acid residues in polypeptide hormones, neurotransmitters, growth factors, substrates, antigens, and other bioactive peptides have been demonstrated to be extremely important pharmacophores for receptor/acceptor binding and for signal transduction (1). Therefore, complete understanding of the stereochemical requirements of side chain groups important in peptide ligand-receptor/acceptor interactions plays a crucial role in the rational design of bioactive peptides and nonpeptide mimetics. Topographical considerations provide a major approach to explore the structure-activity relationships of the side chains of the amino acid residues in the bioactive peptide analogues (2). This approach can be realized by incorporation of conformationally constrained unusual amino acids into a peptide or nonpeptide template. Thus, design and synthesis of unusual amino acids with specific biased side chain conformations have tremendous impact on the exploration of the mechanism of peptide ligand-receptor recognition and of activating signal transduction. Our laboratory has been engaged in the design and synthesis of conformationally constrained amino acids for almost a decade. One representative family among the special amino acids we have designed is the β-substituted unusual amino acids, in which substitution of the diastereotopic β-hydrogens of natural α-amino acids provides an approach to topographic control of side chain conformation (3). Incorporation of these β-substituted unusual amino acids into bioactive peptide hormones has produced highly selective and potent peptide hormone analogues and provided new insights into the stereochemical requirements in peptide-receptor interactions (4).
Variability Analysis of Multiport Systems Via Polynomial-Chaos Expansion (2012)

We present a novel technique to perform variability analysis of multiport systems. The versatility of the proposed technique makes it suitable for the analysis of different types of modern electrical systems (e.g., interconnections, filters, connectors). The proposed method, based on the calculation of a set of univariate macromodels and on the use of the polynomial chaos expansion, produces a macromodel of the transfer function of the multiport system including its statistical properties. The accuracy and the significant speed up with respect to the classical Monte Carlo analysis are verified by means of two numerical examples.
Transformation optical design of a bending waveguide by use of isotropic materials (2009)

Based on the effective medium theory, we designed a simplified transformation media bending waveguide by use of only three kinds of isotropic material in an alternating layered structure. The design can be used to guide incoming waves smoothly along the bending part of a waveguide with slight distortions. Numerical simulations are performed to illustrate its functionality.
Measurement and Quantification of Cystometric Bladder Pressure Spectra in an in-vivo Sheep Model: A Feasibility Study (2021)

Cystometry is a standard procedure for the clinical evaluation of lower urinary tract disorders such as detrusor overactivity (DO). The utility of this procedure for DO diagnosis, however, is limited by the use of physician observations of bladder contractions and patient reported filling sensations. Although a number of preclinical and clinical studies have observed and developed methods to characterize bladder pressure dynamics, these techniques have not been scaled for routine clinical application. The goal of this study was to evaluate the feasibility of using an awake large animal model to characterize bladder pressure signals from cystometry as bladder pressure spectra and quantify changes in spectra during bladder filling. Two adult female sheep were trained for quiet catheterization in a minimally supportive sling and underwent multiple awake and limited anesthetized cystometry tests. In each test, bladder pressure was measured during continuous filling or with filling that included periods of no filling (constant volume). A Fast-Fourier Transform (FFT)-based algorithm was then used to quantify changes in pre-voiding bladder pressure spectra. Changes in Spectral Power (SP) and Weighted Average Frequency (WAF) were calculated during filling. To visualize temporal changes in bladder pressure frequencies during filling, Continuous Wavelet Transform (CWT) was also applied to cystometry data. Results showed that a significant increase in SP and decrease in WAF were both associated with bladder filling. However, during awake constant volume tests, SP significantly increased while changes in WAF were nonsignificant. Anesthetized tests demonstrated comparable values to awake tests for WAF while SP was considerably reduced. CWT facilitated visualization of spectral changes associated with SP and WAF as well as apparent non-voiding contractions during awake and anesthetized volume tests.Clinical Relevance-Bladder pressure spectra during cystometry are detectable in sheep and the changes during filling are similar to those observed in human retrospective clinical data. Sheep cystometry may be a valuable testbed for establishing and testing quantitative pressure spectra for use as a clinical diagnostic tool.
One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents (1998)

One-week omeprazole/clarithromycin/tinidazole triple therapy is highly tolerable and effective for treating H pylori in the pediatric age group, but previous treatment failure diminishes the likelihood of success with this regimen.
Erratum: Enhanced cross-recognition of SARS-CoV-2 Omicron variant by peptide vaccine-induced antibodies (2023)

[This corrects the article DOI: 10.3389/fimmu.2022.1044025.].
Day-Surgery Patients Anesthetized With Propofol Have Less Postoperative Pain Than Those Anesthetized With Sevoflurane (2011)

Department of Anaesthesia and Perioperative Medicine, Coombe Women and Infants University Hospital, Dublin, Ireland.
Soft sensors that can feel it all (2020)

Soft materials and machine learning combine to enable a sensor that distinguishes bending, stretching, and compression.
ChemInform Abstract: Double Diels—Alder Strategies to Soluble 2,9‐ and 2,9,6,13‐Tetraethynylpentacenes, Photolytic [4 + 4] Cycloadditions, and Pentacene Crystal Packing. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model (2020)

Programmed cell death protein 1 (PD-1) checkpoint blockade with an antibody has been shown to reduce amyloid-β plaques, associated pathologies and cognitive impairment in mouse models. More recently, this approach has shown effectiveness in a tauopathy mouse model to improve cognition and reduce tau lesions. Follow-up studies by other laboratories did not see similar benefits of this type of therapy in other amyloid-β plaque models. Here, we report a modest increase in locomotor activity but no effect on cognition or tau pathology, in a different more commonly used tauopathy model following a weekly treatment for 12 weeks with the same PD-1 antibody and isotype control as in the original Aβ- and tau-targeting studies. These findings indicate that further research is needed before clinical trials based on PD-1 checkpoint immune blockage are devised for tauopathies.
Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease (2019)

Growth factors can facilitate hippocampus-based learning and memory and are potential targets for treatment of cognitive dysfunction via their neuroprotective and neurorestorative effects. Dementia is common in Parkinson's disease (PD), but treatment options are limited. We aimed to determine if levels of growth factors are altered in the hippocampus of patients with PD, and if such alterations are associated with PD pathology. Enzyme-linked immunosorbent assays were used to quantify seven growth factors in fresh frozen hippocampus from 10 PD and nine age-matched control brains. Western blotting and immunohistochemistry were used to explore cellular and inflammatory changes that may be associated with growth factor alterations. In the PD hippocampus, protein levels of glial cell line-derived neurotrophic factor were significantly decreased, despite no evidence of neuronal loss. In contrast, protein levels of fibroblast growth factor 2 and cerebral dopamine neurotrophic factor were significantly increased in PD compared to controls. Levels of the growth factors epidermal growth factor, heparin-binding epidermal growth factor, brain-derived neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor did not differ between groups. Our data demonstrate changes in specific growth factors in the hippocampus of the PD brain, which potentially represent targets for modification to help attenuate cognitive decline in PD. These data also suggest that multiple growth factors and direction of change needs to be considered when approaching growth factors as a potential treatment for cognitive decline.
Decorating Parylene-Coated Glass with ZnO Nanoparticles for Antibacterial Applications: A Comparative Study of Sonochemical, Microwave, and Microwave-Plasma Coating Routes (2010)

A glass substrate, coated with a Parylene film, was coated with ZnO by three different methods: ultrasound, microwave, and microwave-plasma irradiation. These coating modes are simple, efficient, and environmentally friendly one-step processes. The structure of the coated products was characterized and compared using methods such as XRD, HR-SEM, EDS, RBS, and optical spectroscopy. Coating by ZnO nanoparticles was achieved for all three approaches. The products were found to differ in their particle sizes, coating thickness, and depth of penetration. All of the ZnO-Parylene-glass composites demonstrated a significant antibacterial activity against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) strains.
Adaptive and heuristic techniques for laser assisted forming of plate (2000)

Prior work has shown that thermal processing by laser irradiation may be used to form components into relatively complex shapes at relatively high production rates and without the necessity of ancillary tooling. However, the most effective means of obtaining predefined shapes by laser assisted forming requires a combination of adaptive sensing and control technology that incorporates the use of a knowledge-base. To accomplish this, an automated system for laser assisted forming of shipyard components has been proposed. The system would utilize predictive and adaptive processing capabilities to achieve the desired shape. The proposed laser assisted forming system would include a laser and robotic system, a controller having an imbedded heuristic-based system, and laser sensors. The forming system would be capable of accepting and utilizing data generated during design of components. The design data would be used to provide the predefined shape necessary for comparison to measured data obtained during the forming progression.