gebhart/patrepeval huggingface dataset:
Single-molecule controlled emission in planar plasmonic cavities (2014)

We study the fluorescence emission from single dye molecules in coplanar plasmonic cavities composed of a thin gold film surrounded by two in-plane surface plasmon Bragg mirrors. We first discuss the effect of the presence of Bragg mirrors on the radiation diagram of surface plasmon coupled emission. Then, we investigate the role of the planar cavity size by single-molecule fluorescence lifetime imaging. Experimental data are compared to numerical simulations of the decay rates calculated as a function of the molecule orientation and position within the cavity. The creation of new decay channels by coupling to the cavity modes is also discussed. We measure a plasmonic Purcell factor up to five, attributed to the enhancement of the radiative rate.
Risk of recurrent venous thromboembolism among deep vein thrombosis and pulmonary embolism patients treated with warfarin (2014)

Approximately 8% of patients experienced a recurrent VTE during follow-up. Subtherapeutic INR levels were associated with a more than three-fold increased risk of VTE recurrence.
Considerations and Challenges for Large Area Embedded Micro-channels with 3D Manifold in High Heat Flux Power Electronics Applications (2020)

Embedded microchannel with 3D manifold heat sinks (EMMCs) offer two primary advantages over conventional microchannel heat sinks: increased thermal performance and decreased pressure loss. The unique 3D fluid routing mechanism of the manifold reduces pressure losses and, resultantly, reduces required pumping power. Previous simulations and experimental studies have been limited to cooling of small footprint electronics, typically on the order of 5×5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This work explores the effects of scaling up the footprint of the cooling area using single phase water. A constant heat flux is applied at the top of the microchannel cold plate and the manifold routes fluid in and out of this cold plate. Achieving similar thermal performance with a larger footprint necessitates scaling flow rate approximately proportional to area. Therefore, significantly higher pressure losses are expected as the heater area is scaled up from 5×5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 20×20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . For example, in order to achieve a target performance of 0.078 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -K/W, pressure drops from the inlet to outlet are 2 and 35 kPa for the 5×5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 20×20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , respectively. In addition, increasing the flow rate of liquid results in the location of the hottest spot on the device shifting away from the center of the device. Finally, this paper discusses ongoing and future experimental work and methods of improving thermal and pressure performance in large-scale EMMCs.
Fluid Dynamic Analysis of Hand-Pump Infuser and UROMAT Endoscopic Automatic System for Irrigation Through a Flexible Ureteroscope (2018)

The flow rates of irrigation produced by the HP and the E.A.S.I. pump are similar at pressures of 150 and 200 mm Hg irrespective of the occupancy of a ureteroscope's working channel during the first 5-minutes of irrigation. Irrigation pressure at the entry site of the ureteroscope is subject to significant variability with use of the HP compared to the E.A.S.I. pump irrigation system.
Sequence of 129 Nucleotides at the 3′‐Terminus of Encephalomyocarditis Virus RNA (1978)

The sequence of 129 nucleotides next to the poly(A) tail of encephalomyocarditis virus RNA has been determined by rapid gel sequencing of cDNA synthesized with DNA polymerase I or reverse transcriptase and a phasing primer, [5'-32P]p(dT)8dC. The sequence is in accord with (a) the pyrimidine tracts which were mapped in blocks along the cDNA, (B) the sequences of seven characteristic T1 RNase oligonucleotides in the RNA transcribed from the cDNA with RNA polymerase, and (c) a limited amount of sequence deduced by partial spleen phosphodiesterase digestion and depurination of endonuclease IV oligonucleotides. The 3' end shows little secondary structure on its own. Ten nonsense codons block all three reading frames such that at least 26 nucleotides do not code for protein. The possible function of a homology A-A-U-A-A-A with other polyadenylated RNAs is discussed.
Interpretation of Low-Frequency Inductive Loops in PEM Fuel Cells (2007)

International audience
Detection of RF unsafe devices using a parallel transmission MR system (2012)

In this study, basic feasibility to detect RF unsafe conditions was successfully demonstrated. In the future, RF patient safety may be improved in the presence of implanted devices, as well as during interventions using this concept.
Kinetics and Thermodynamics of Drug Permeation Through Silicone Elastomers III. Effect of Alkyl Substituent (R) in (MeRSiO) Polymer (1986)

The effect of silicone polymer structure on the permeability of drug through silicone membranes was investigated in the capsule-type drug delivery system. The permeability, diffusivity and solubility of progesterone and testosterone through polymethylalkylsiloxane membranes, (MeCn H2n+1 SiO)x, where n = 1, 2, 3, 6 and 8, were determined at 25, 37 and 50°C respectively.As the size of the alkyl substituent was increased from methyl to octyl, the diffusivity decreased, whereas the solubility increased. As a result, the permeability of progesterone decreased initially but increased gradually thereafter, going from (Me2SiO)x to (MeOctSiO)x, in this series of polymer. The same results were obtained with testosterone; however, permeabilities of testosterone were found to be one order of magnitude lower than those of progesterone. This was attributed to the lower solubilities of testosterone in (MeRSiO)x polymers when compared to those for progesterone. The activation energies of permeation for progesterone in these polymers were found to be in the range of 13-15 Kcal/mol.
Data from AMG 900, a Small-Molecule Inhibitor of Aurora Kinases, Potentiates the Activity of Microtubule-Targeting Agents in Human Metastatic Breast Cancer Models (2023)

&lt;div&gt;Abstract&lt;p&gt;Breast cancer is the most prevalent malignancy affecting women and ranks second in cancer-related deaths, in which death occurs primarily from metastatic disease. Triple-negative breast cancer (TNBC) is a more aggressive and metastatic subtype of breast cancer that is initially responsive to treatment of microtubule-targeting agents (MTA) such as taxanes. Recently, we reported the characterization of AMG 900, an orally bioavailable, potent, and highly selective pan-Aurora kinase inhibitor that is active in multidrug-resistant cell lines. In this report, we investigate the activity of AMG 900 alone and in combination with two distinct classes of MTAs (taxanes and epothilones) in multidrug-resistant TNBC cell lines and xenografts. In TNBC cells, AMG 900 inhibited phosphorylation of histone H3 on Ser&lt;sup&gt;10&lt;/sup&gt;, a proximal substrate of Aurora-B, and induced polyploidy and apoptosis. Furthermore, AMG 900 potentiated the antiproliferative effects of paclitaxel and ixabepilone at low nanomolar concentrations. In mice, AMG 900 significantly inhibited the growth of MDA-MB-231 (F&lt;sup&gt;11&lt;/sup&gt;; parental), MDA-MB-231 (F&lt;sup&gt;11&lt;/sup&gt;) PTX-r (paclitaxel-resistant variant), and DU4475 xenografts. The combination of AMG 900 with docetaxel enhanced tumor inhibition in MDA-MB-231 (F&lt;sup&gt;11&lt;/sup&gt;) xenografts compared with either monotherapy. Notably, combining AMG 900 with ixabepilone resulted in regressions of MDA-MB-231 (F&lt;sup&gt;11&lt;/sup&gt;) PTX-r xenografts, in which more than 50% of the tumors failed to regrow 75 days after the cessation of drug treatment. These findings suggest that AMG 900, alone and in combination with MTAs, may be an effective intervention strategy for the treatment of metastatic breast cancer and provide potential therapeutic options for patients with multidrug-resistant tumors. &lt;i&gt;Mol Cancer Ther; 12(11); 2356–66. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Superior signal persistence of circularly polarized light in polydisperse, real-world fog environments (2018)

We present simulation results quantitatively showing that circularly polarized light persists in transmission through several real-world and model fog environments better than linearly polarized light over broad wavelength ranges from the visible through the infrared. We present results for polydisperse particle distributions from realistic and measured fog environments, comparing the polarization persistence of linear and circular polarization. Using a polarization-tracking Monte Carlo program, we simulate polarized light propagation through four MODTRAN fog models (moderate and heavy radiation fog and moderate and heavy advection fog) and four real-world measured fog particle distributions (Garland measured radiation and advection fogs, Kunkel measured advection fog, and Sandia National Laboratories' Fog Facility's fog). Simulations were performed for each fog environment with wavelengths ranging from 0.4 to 12 µm for increasing optical thicknesses of 5, 10, and 15 (increasing fog density or sensing range). Circular polarization persists superiorly for all optical wavelength bands from the visible to the long-wave infrared in nearly all fog types for all optical thicknesses. Throughout our analysis, we show that if even a small percentage of a fog's particle size distribution is made up of large particles, those particles dominate the scattering process. In nearly all real-world fog situations, these large particles and their dominant scattering characteristics are present. Larger particles are predominantly forward-scattering and contribute to circular polarization's persistence superiority over broad wavelength ranges and optical thicknesses/range. Circularly polarized light can transmit over 30% more signal in its intended state compared to linearly polarized light through real-world fog environments. This work broadens the understanding of how circular polarization persists through natural fog particle distributions with natural variations in mode particle radius and single or bimodal characteristics.
Oxime Derivatives as α-Electrophiles. From α-Tetralone Oximes to Tetracyclic Frameworks (2011)

When subjected to the conditions of a Semmler-Wolff/Schroeter aromatization, the oximes of 4-benzyl-substituted tetralones undergo an electrophilic aromatic substitution reaction to form tetracyclic frameworks.
Friction on a single MoS2 nanotube (2012)

Friction was measured on a single molybdenum disulfide (MoS2) nanotube and on a single MoS2 nano-onion for the first time. We used atomic force microscopy (AFM) operating in ultra-high vacuum at room temperature. The average coefficient of friction between the AFM tip and MoS2 nanotubes was found considerably below the corresponding values obtained from an air-cleaved MoS2 single crystal or graphite. We revealed a nontrivial dependency of friction on interaction strength between the nanotube and the underlying substrate. Friction on detached or weakly supported nanotubes by the substrate was several times smaller (0.023 ± 0.005) than that on well-supported nanotubes (0.08 ± 0.02). We propose an explanation of a quarter of a century old phenomena of higher friction found for intracrystalline (0.06) than for intercrystalline slip (0.025) in MoS2. Friction test on a single MoS2 nano-onion revealed a combined gliding-rolling process.PACS, 62.20, 61.46.Fg, 68.37 Ps.
Carrier Diffusivity in Porous Membranes (2003)

Carrier diffusivity of a lithium electrolyte solution in porous membranes was evaluated by observation of diffusion behavior of ionic species using NMR spectroscopy. We performed analysis on the basis of the restricted diffusion model and a new idea of diffusion distribution. That new concept is engendered in the assumption that observed diffusion values are distributed according to pore size distribution and nonuniformity of pore and polymer density in a membrane. Carrier diffusivity in polyethylene (PE) porous membranes showed characteristic echo attenuation, which differs from echo behavior as a result of random walk migration. We first tried to simulate the echo change on the basis of the restricted diffusion model in porous structure, resulting in disagreement with the observed echo change. As a result, the idea that diffusion values are distributed concurrent with porous geometry was applied to interpret the situation. Introduction of a Gaussian function to represent the distributed condition yielded highly reproducible results for the membranes. Carrier diffusivity in porous PVDF membranes showed a narrow distribution compared with that of PE membrane. The swelling feature of the PVDF polymer would contribute to averaging the pore size and preparing the uniform network for carrier transport pathway.
Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery (2010)

A fluorescence confocal microscope incorporating a 1.8-mm-diam gradient-index relay lens is developed for in vivo histological guidance during resection of brain tumors. The microscope utilizes a dual-axis confocal architecture to efficiently reject out-of-focus light for high-contrast optical sectioning. A biaxial microelectromechanical system (MEMS) scanning mirror is actuated at resonance along each axis to achieve a large field of view with low-voltage waveforms. The unstable Lissajous scan, which results from actuating the orthogonal axes of the MEMS mirror at highly disparate resonance frequencies, is optimized to fully sample 500x500 pixels at two frames per second. Optically sectioned fluorescence images of brain tissues are obtained in living mice to demonstrate the utility of this microscope for image-guided resections.
ChemInform Abstract: Metal ‐ Metal Bonds Involving Actinides. Synthesis and Characterization of a Complex Having an Unsupported Actinide to Transition‐Metal Bond. (1986)

Abstract The reaction shown in the scheme affords the air‐sensitive ThRu complexes (III).
Lack of Sex Differences in Muscle Stem Cell Transplantation for Cardiac Repair (2008)

Cellular transplantation of stem cells is a potential method of repairing damaged myocardium. We identified a novel population of muscle‐derived stem cells (MDSCs) that can repair cardiac muscle. Sex differences have been seen in cardiovascular diseases and cellular therapy. Differences in regenerative capacity of male and female MDSCs have been observed in skeletal muscle and bone. In this study we compared male and female MDSCs to determine if there was a sex difference for cardiac repair. MDSCs were implanted into the hearts of both a cardiomyopathy mouse model and a myocardial infarction model. In the cardiomyopathy model, five populations of male and female cells were injected into both male and female mice. No differences were found with either host sex or cell sex in engraftment or blood vessels. For the injury model, cells were divided into 4 groups – high and low engrafting cells from both sexes, and injected into SCID mice after infarction to assess function at six weeks. No difference was seen in function between the groups, though all cell‐injected groups were significantly better than PBS controls. The infarcted hearts were stained for scar tissue, blood vessels, and engraftment, and no difference was seen between the cell groups. Though our lab has previously shown sex differences with MDSCs in skeletal muscle and bone, this does not appear to be the case in cardiac muscle. Since MDSCs seem to repair the heart through secretion of VEGF and chemoattracting host cells rather than directly regenerating the myocardium, this could explain why no difference was observed between male and female cells. This work was funded by grants to J. Huard from the MDA, the NIH (1U54AR050733‐01, HL 069368) and L. Drowley from the NIH (T32 EB001026‐05).
Simultaneous Separation, Metering, and Dilution of Plasma from Human Whole Blood in a Microfluidic System (2009)

In about a 3 min period, we have simultaneously separated plasma from human whole blood and metered and diluted the plasma using a microchip with an interchannel microstructure. The plasma separation was based on both cross-flow filtration and sedimentation of red blood cells in the microchannels. Metering and diluting operations of the plasma were based on volume control of liquid in the microchannels by syringe pumps. On this microchip, we produced plasma diluted by a factor of 6 from whole blood containing theophylline and we observed very little hemolysis. It is possible to separate plasma from one or just several drops of whole blood by using this microchip.
Theories of Fever From Antiquity to the Enlightenment (1982)

Despite the fact that the availability, acceptance, and use of clinical thermometers in medical practice is relatively recent medical history (Wunderlich's classic paper on clinical thermometry and fever was published in 1842), there is a wealth of treatises, books, pamphlets, and illustrations on the subject of fever as a general sign of disease as well as as a diagnostic pool of the prevailing infectious diseases in the world. Medical historians considering various theories on fever during these 2,000 years also encounter a history of scientific philosophy. Theories on Fever From Antiquity to the Enlightenment is a compilation of seven essays that were delivered at a meeting of the Wellcome Institute for the History of Medicine in June 1980. The seven articles are each expertly researched and clearly presented in the context of the specific theories of fevers and, in addition, the social, religious, and political effects such theories had
<title>Adaptive Markovian model for 3D x-ray vascular reconstruction</title> (1995)

The Bayesian approach combined with the Markov random field approach provide a powerful and consistent mathematical framework for taking into account a priori knowledge and for regularizing ill-posed problems. Applied to 3D x-ray vascular reconstruction, such a combining approach requires a 3D object model describing the vascular tree. To take into account characteristic features of blood vessels, the proposed model performs a sort of shape analysis in order to estimate non-stationary parameters of the Markovian model. The global energy function is then expressed as a weighted combination of an adaptive smoothing potential which favors smoothing along the vessel direction; an enhancing potential which increases the contrast of small vessels; and a data-dependent term based on the difference between reprojection of the 3D reconstructed object and observed projections.
Highly-damped nanofiber mesh for ultrasensitive broadband acoustic flow detection (2018)

Many small animals have evolved ultrasensitive hearing capability by detecting acoustic flow with mechanosensory hair-like structures. The highly-damped hairy structures such as the fluffy mosquito antennae are driven to move by viscous forces in the fluctuating medium, in contrast to sensing acoustic pressure with tympanal membranes. Inspired by the acoustic flow sensing of animals, the highly-damped 2D nanofiber mesh is presented here for the ultrasensitive, broadband acoustic flow detection. By evaporating 90 nm Au on a freestanding electrospun Poly(methyl methacrylate) (PMMA) nanofiber mesh, we fabricate a thin layer of conductive Au-PMMA nanomesh with dimensions 8 mm × 8 mm, with thickness of approximately 3 μm and average fiber diameter around 430 nm. The nanomesh is shown to move instantaneously with broadband fluctuating airflow near maximum physical efficiency from 100 Hz to 10 000 Hz, i.e. , surpassing the frequency response and efficiency of previously-reported microscale hairy structures. By transducing the motion of the nanomesh with electromagnetic induction, we demonstrate fluctuating airflow detection with almost full fidelity in the measured frequency range. Sensing flow with highly-damped nanomaterials will benefit miniaturized flow measurement and sound detection, and provides an important application for the diverse flourishing nanomaterials, such as 1D nanofibers, 2D nanomeshes, and 3D nanolattices.
A database on endemic plants at Tirumala hills in India (2008)

http://svimstpt.ap.nic.in/MedicinalPlants/mainpage.htm.
Synthesis of Tetrafluoroethylene-Based, Nonaqueous Fluoropolymers in Supercritical Carbon Dioxide (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Tetrafluoroethylene-Based, Nonaqueous Fluoropolymers in Supercritical Carbon DioxideT. J. Romack, J. M. DeSimone, and T. A. TreatCite this: Macromolecules 1995, 28, 24, 8429–8431Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ma00128a065https://doi.org/10.1021/ma00128a065research-articleACS PublicationsRequest reuse permissionsArticle Views485Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protocol to engineer apical-out airway organoids using suspension culture of human airway basal stem cell aggregates (2023)

Here we present a protocol to engineer apical-out airway organoids (AOAOs) directly from human airway basal stem cells (hABSCs) using suspension culture of hABSC aggregates on a cell-repellent surface. We describe steps to produce spherical AOAOs with homogenous presentation of exterior-facing motile cilia and of tunable sizes. We then detail procedures to analyze AOAO cellular composition via wholemount staining and assess cilia motility via 3D AOAO rotation upon Matrigel embedding. The protocol offers an effective model for investigating human airway pathophysiology. For complete details on the use and execution of this protocol, please refer to Wijesekara et al. (2022).<sup>1</sup>.