gebhart/patrepeval huggingface dataset:
Neural network of superiority illusion predicts the level of dopamine in striatum (2022)

Abstract In evaluating the personality attributes and performance of the self, people are inclined to view themselves superior to others, a phenomenon known as superiority illusion (SI). This illusive outlook pervades people’s thoughts, creating hope for the future and promoting mental health. Although a specific cortico-striatal functional connectivity (FC) under dopaminergic modulation was previously shown to be implicated in SI, the underlying whole-brain mechanisms have remained unclarified. Herein, to reveal the neural network subserving individual’s SI, we conducted a data-driven, machine-learning investigation to explore the resting-state FC network across the whole brain. Using the locally-acquired resting-state functional magnetic resonance imaging data ( n = 123), we identified a set of 15 FCs most informative in classifying individuals with higher-versus lower-than-average levels of SI in evaluating positive trait words (area under the curve [AUC] = 0.81). Among the 15 FCs, the contribution level to the classification was 11% by the previously-highlighted cortico-striatal FC alone, but 60% by the encompassing cortico-limbico-striatal network cluster. A newly-identified, cortico-thalamic FC and another FC cluster also demonstrated substantial contribution. The classification accuracy was generalized into an independent cohort ( n = 36; AUC = 0.73). Importantly, using the same set of 15 FCs, we achieved prediction on an individual’s level of striatal dopamine D 2 receptor availability (Pearson correlation, r = 0.46, P = 0.005). This is the first successful identification of the whole-brain neural network that simultaneously predicts the behavioral manifestation and molecular underpinning of an essential psychological process that promotes well-being and mental health. Significance Statement Superiority illusion (SI) is a basic self-referential framework that pervades people’s thoughts and promotes well-being and mental health. An aberrant form of SI has been reported in psychiatric conditions such as depression. Our hypothesis-free, data-driven investigation revealed the spatially-distributed neural network that for the first time achieved prediction on an individual’s levels of SI and the striatal dopaminergic transmission simultaneously. In principle, this multiple-biological-layer framework can be applicable to any behavioral trait to establish a link with its underlying neural network and neurochemical properties, which could quantitatively present the relation of its aberrant form with the pathophysiology of neuropsychiatric disorders. Future clinical research may aid in deriving a diagnostic biomarker for examining the related behavioral and neurochemical characteristics within individuals.
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway (1999)

STAT1 is an essential transcription factor for macrophage activation by IFN-gamma and requires phosphorylation of the C-terminal Ser727 for transcriptional activity. In macrophages, Ser727 phosphorylation in response to bacterial lipopolysaccharide (LPS), UV irradiation, or TNF-alpha occurred through a signaling path sensitive to the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580 whereas IFN-gamma-mediated Ser727 phosphorylation was not inhibited by the drug. Consistently, SB203580 did not affect IFN-gamma-mediated, Stat1-dependent transcription but inhibited its enhancement by LPS. Furthermore, LPS, UV irradiation, and TNF-alpha caused activation of p38 MAPK whereas IFN-gamma did not. An essential role for p38 MAPK activity in STAT1 Ser727 phosphorylation was confirmed by using cells expressing an SB203580-resistant p38 MAPK. In such cells, STAT1 Ser727 phosphorylation in response to UV irradiation was found to be SB203580 insensitive. Targeted disruption of the mapkap-k2 gene, encoding a kinase downstream of p38 MAPK with a key role in LPS-stimulated TNF-alpha production and stress-induced heat shock protein 25 phosphorylation, was without a significant effect on UV-mediated Ser727 phosphorylation. The recombinant Stat1 C terminus was phosphorylated in vitro by p38MAPKalpha and beta but not by MAPK-activated protein kinase 2. Janus kinase 2 activity, previously reported to be required for IFN-gamma-mediated Ser727 phosphorylation, was not needed for LPS-mediated Ser727 phosphorylation, and activation of Janus kinase 2 did not cause the appearance of STAT1 Ser727 kinase activity. Our data suggest that STAT1 is phosphorylated at Ser727 by a stress-activated signaling pathway either through p38 MAPK directly or through an unidentified kinase downstream of p38MAPK.
Table S4 from RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3 (2023)

&lt;p&gt;Cox regression analysis of potential prognostic predictors for patients in the colorectal cancer cohort (HongKong cohort 1 and BeiJing cohort 1, n=160)&lt;/p&gt;
Antibiotic susceptibility pattern of Enterobacteriaceae and non-fermenter Gram-negative clinical isolates of microbial resource orchid (2015)

This study demonstrated the high level of antibiotic resistance among the strains collected under microbial resource orchid and further, such data and the strains can be used in new chemical entities profiling.
Molecular Interaction between a Gadolinium–Polyoxometalate and Human Serum Albumin (2009)

Abstract Polyoxometalates (POMs) show promising antibacterial, antiviral (particularly anti‐HIV), antitumor, and anticancer activities, but the mechanism of these potential therapeutic effects remains to be elucidated at the molecular level. The interaction between the Gd‐containing tungstosilicate [Gd(β 2 ‐SiW 11 O 39 ) 2 ] 13– and human serum albumin (HSA) was studied by several techniques. Fluorescence spectroscopy showed an energy transfer between the single tryptophan residue of HSA and the POM. Circular dichroism led to the conclusion that the POM significantly altered the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy‐driven binding reaction between HSA and the POM, resulting in the formation of a 1:1 complex.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
First-in-Human Randomized, Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector (2018)

NCT02218125.
Mitogenic activity of GRP18–27 analogues on the ZR-75-1 human breast cancer cell line (1990)

Conference Article| April 01 1990 Mitogenic activity of GRP18–27 analogues on the ZR-75-1 human breast cancer cell line MARIE DONNELLY; MARIE DONNELLY 1Department of Biochemistry, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN NELSON; JOHN NELSON 1Department of Biochemistry, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar BRIAN WALKER; BRIAN WALKER 1Department of Biochemistry, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOE GRAY; JOE GRAY 1Department of Biochemistry, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar RICHARD F. MURPHY RICHARD F. MURPHY 1Department of Biochemistry, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (2): 354. https://doi.org/10.1042/bst0180354 Article history Received: September 14 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MARIE DONNELLY, JOHN NELSON, BRIAN WALKER, JOE GRAY, RICHARD F. MURPHY; Mitogenic activity of GRP18–27 analogues on the ZR-75-1 human breast cancer cell line. Biochem Soc Trans 1 April 1990; 18 (2): 354. doi: https://doi.org/10.1042/bst0180354 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: GRP, gastrin-releasing peptide, DDC, dextran-coated, charcoal stripped, FCS, foetal calf serum This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Accelerated Time-Domain Modeling of Electromagnetic Pulse Excitation of Finite-Length Dissipative Conductors over a Ground Plane via Function Fitting and Recursive Convolution (2017)

In this report we overview the fundamental concepts for a pair of techniques which together greatly hasten computational predictions of electromagnetic pulse (EMP) excitation of finite-length dissipative conductors over a ground plane. In a time- domain, transmission line (TL) model implementation, predictions are computationally bottlenecked time-wise, either for late-time predictions (about 100ns-10000ns range) or predictions concerning EMP excitation of long TLs (order of kilometers or more ). This is because the method requires a temporal convolution to account for the losses in the ground. Addressing this to facilitate practical simulation of EMP excitation of TLs, we first apply a technique to extract an (approximate) complex exponential function basis-fit to the ground/Earth's impedance function, followed by incorporating this into a recursion-based convolution acceleration technique. Because the recursion-based method only requires the evaluation of the most recent voltage history data (versus the entire history in a "brute-force" convolution evaluation), we achieve necessary time speed- ups across a variety of TL/Earth geometry/material scenarios. Intentionally Left Blank
Multiband optics for imaging systems (Conference Presentation) (2016)

There is a strong desire to reduce size and weight of single and multiband IR imaging systems in Intelligence, Surveillance and Reconnaissance (ISR) operations on hand-held, helmet mounted or airborne platforms. NRL is developing new IR glasses that expand the glass map and provide compact solutions to multispectral imaging systems. These glasses were specifically designed to have comparable glass molding temperatures and thermal properties to enable lamination and co-molding of the optics which leads to a reduction in the number of air-glass interfaces (lower Fresnel reflection losses). Our multispectral optics designs using these new materials demonstrate reduced size, complexity and improved performance. This presentation will cover discussions on the new optical materials, multispectral designs, as well fabrication and characterization of new optics. Additionally, graded index (GRIN) optics offer further potential for both weight savings and increased performance but have so far been limited to visible and NIR bands (wavelengths shorter than about 0.9 µm). NRL is developing a capability to extend GRIN optics to longer wavelengths in the infrared by exploiting diffused IR transmitting chalcogenide glasses. These IR-GRIN lenses are compatible with all IR wavebands (SWIR, MWIR and LWIR) and can be used alongside conventional materials. The IR-GRIN lens technology, design space and anti-reflection considerations will be presented in this talk.
2A2-B06 A Study on a Small Sized Flapping Robot Flight (2007)

We developed a motor-driven ornithopter for investigating the relationship between flapping frequencies and flight kinematics of insects. Wings were designed to have 150 mm span so that Reynolds number of the ornithopter was the same order as that of insects (Re〜10^4). Flights of the ornithopter were recorded with a high speed video camera in flapping frequencies from 9.9 Hz to 13.3 Hz, and their motions were analyzed. We clarified the mean angle of attack decreased as the flapping frequency became higher. We also developed FM-telemetry system to measure directly aerodynamic forces generated by wings in free flight. The telemeter was miniaturized to attach to the ornithopter. The total size and weight were respectively 30 mm×15 mm and 1.33 g. To estimate aerodynamic forces, we measured the moment of the leading edge of the wing with strain gages. We found the difference of aerodynamic forces between in free flight and in tethered state.
Molecular cloning and expression of Clostridium difficile toxin A in Escherichia coli K 12 (1987)

Clostridium difficile toxin A was purified to homogeneity and was used to raise monospecific antiserum in rabbits. A gene bank of C. difficile DNA in Escherichia coli was constructed by cloning Sau3A-cleaved clostridial DNA fragments into the bacteriophage vector lambda EMBL3. Out of 4500 plaques screened with antitoxin A, 9 clones were positively identified. One of these clones lambda tA5 expressed a 235 kDa protein which exhibited a cytotonic effect on Chinese hamster ovary cells, and had the ability to haemagglutinate rabbit erythrocytes, both properties characteristic of toxin A. The size of the lambda tA5 insert DNA was 14.3 kb.
DSP-Free 25-Gbit/s PAM-4 Transmission Using 10G Transmitter and Coherent Amplification (2018)

We demonstrate 25-Gbit/s four-level pulse amplitude modulation transmission over 28-km standard single-mode fiber using an off-the-shelf 10-Gbit/s electro-absorption modulated laser and a 3 × 3 fiber splitter based simplified coherent receiver in the C-band. No digital signal processing and dispersion compensation have been used either at the transmitter or at the receiver. Furthermore, the use of an intensity modulated signal allows us to avoid the phase and frequency locking of the local oscillator. We achieved receiver sensitivities of -18.25, -17, and -13.4 dBm at a bit error rate below the hard-decision forward error correction threshold (i.e., 3.8×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> ) and power budgets of 20.80, 19.55, and 15.95 dB in back-to-back, after 20.7 and 28 km, respectively. We also demonstrate polarization independent operation by slightly modifying the architecture of the simplified coherent receiver.
Chemical Models of Cytochrome P450 Catalyzed Insecticide Metabolism. Application to the Oxidative Metabolism of Carbamate Insecticides (1999)

Cytochrome P450 (CP450) catalyzed oxidative metabolism of carbofuran (1), carbaryl (2), and pirimicarb (3) has been modeled using biomimetic oxidations catalyzed by iron(III) tetraarylporphyrins. Oxidation products of 1 were identified by comparison of HPLC retention times measured under standardized conditions for metabolites synthesized and characterized by (1)H and (13)C NMR spectroscopy. Comparison of product distributions to in vivo metabolic profiles revealed that the H(2)O(2)/meso-tetrakis(pentafluorophenyl)porphyrin iron(III) chloride [Fe(TF(20)PP)] system mimics the action of insect CP450s against carbofuran. The effectiveness of this system was further demonstrated by the biomimetic oxidation of other carbamate insecticides (2 and 3) monitored by HPLC/electrospray MS. The predictive power of this biomimetic model was compared to that of knowledge-based expert systems. Although similar models were recently applied in pharmaceutical research, the usefulness of this approach has first been demonstrated for the prediction of metabolic profiles of agrochemicals.
Constraint-Based LSP Setup using LDP (2002)

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the &amp;quot;Internet Official Protocol Standards &amp;quot; (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Copyright Notice
New Information On 2H-TaS2Intercalation Chemistry With Organic Bases (1985)

Abstract This contribution describes a quantitative chemical study of the 2H-TaS2 + pyridine reaction at 115°C under rigorously anaerobic and anhydrous conditions (as well as with added water and other reagents). Small amounts of pyridine coupling products (primarily 4,4'-bipyridine) are observed which increase then fall off with increasing water concentrations. Based upon a number of mechanistic tests, the coupling chemistry is tentatively associated with the formation of pyridine cation radicals. 2H-TaSe2 effects the same chemistry without intercalation.
Sensory neuropathy-causing mutations in ATL3 affect ER–mitochondria contact sites and impair axonal mitochondrial distribution (2018)

Axonopathies are neurodegenerative disorders caused by axonal degeneration, affecting predominantly the longest neurons. Several of these axonopathies are caused by genetic defects in proteins involved in the shaping and dynamics of the endoplasmic reticulum (ER); however, it is unclear how these defects impinge on neuronal survival. Given its central and widespread position within a cell, the ER is a pivotal player in inter-organelle communication. Here, we demonstrate that defects in the ER fusion protein ATL3, which were identified in patients suffering from hereditary sensory and autonomic neuropathy, result in an increased number of ER-mitochondria contact sites both in HeLa cells and in patient-derived fibroblasts. This increased contact is reflected in higher phospholipid metabolism, upregulated autophagy and augmented Ca2+ crosstalk between both organelles. Moreover, the mitochondria in these cells display lowered motility, and the number of axonal mitochondria in neurons expressing disease-causing mutations in ATL3 is strongly decreased. These results underscore the functional interdependence of subcellular organelles in health and disease and show that disorders caused by ER-shaping defects are more complex than previously assumed.
Simple and Efficient Separation of Atomically Precise Noble Metal Clusters (2014)

There is an urgent need for accessible purification and separation strategies of atomically precise metal clusters in order to promote the study of their fundamental properties. Although the separation of mixtures of atomically precise gold clusters Au25L18, where L are thiolates, has been demonstrated by advanced separation techniques, we present here the first separation of metal clusters by thin-layer chromatography (TLC), which is simple yet surprisingly efficient. This method was successfully applied to a binary mixture of Au25L18 with different ligands, as well as to a binary mixture of different cluster cores, Au25 and Au144, protected with the same ligand. Importantly, TLC even enabled the challenging separation of a multicomponent mixture of mixed-monolayer-protected Au25 clusters with closely similar chemical ligand compositions. We anticipate that the realization of such simple yet efficient separation technique will progress the detailed investigation of cluster properties.
Adaptive laser tracking using phase-conjugate coupled resonators (2000)

Summary form only given. We report the experimental realization of a coupled laser system that employs a phase conjugate mirror (PCM) and is capable of adaptively tracking a moving output coupler. A number of approaches have been suggested in order to develop a laser system that can lock-on and track a remote object. Active laser-based systems have an advantage over passive systems because they can establish communication channels, measure target velocity and spatial coordinates, and/or deliver high optical power levels. Active systems have been demonstrated in the laboratory using PCMs; however, they have generally been limited to locking on to static or very slow moving objects. For tracking remote, high velocity targets, several problems exist including: low returned power, high Doppler frequency shift, and large temporal delays. In this work we show that laser resonators coupled with a PCM in a Michelson type arrangement can be used to overcome some of these limitations and track a remote moving object.
Modeling of growth rate dispersion of citric acid monohydrate in continuous crystallizers (1984)

Abstract A mathematical model for prediction of the crystal size distribution from a continuous crystallizer is presented. The kinetic data used for the model were obtained from batch contact nucleation experiments with citric acid monohydrate. In these experiments, the distribution of growth rates as well as the initial size distribution were estimated. Results from the model indicate that the excess number of crystals usually present at small sizes in continuous crystallizers is due to growth rate dispersion (where crystals of the same size may have different growth rates) and not size dependent growth.
De l'ortho-lithiation de dérivés iodés aza-aromatiques en général, et de l'application à la synthèse de 2,9-diazaphénanthrènes en particulier (1994)

Data regarding disclosure of HIV status to sexual partners among perinatally acquired HIV-infected (PHIV) youth are limited, particularly from Asian countries. This cross-sectional study assessed the patterns of, attitudes about, and factors associated with HIV disclosure to sexual partners among PHIV youth aged 15-24 years who attended a pediatric HIV clinic in Thailand. Participants were interviewed using a semi-structured questionnaire designed to elicit demographic and sexual behavior information. Those who had sexual partners were queried about their relationship and HIV status disclosure. Reasons to disclose or not to disclose were assessed accordingly. Among the 51 (44.4%) youth who had sexual partners, 55.8% had steady partners, 45.1% did not always use condoms, and 41.2% disclosed their HIV status. Reasons to disclose included trust and concern about the risk of infection to their partners. Reasons not to disclose included fear of rejection and stigmatization, and not knowing how to disclose. Most youth reported a need for disclosure-related guidance. Knowing their sexual partner's HIV status was the only independent factor associated with disclosure (aOR 14.6; 95% CI 2.8-75.4). This study demonstrates a high rate of unsafe sex and a low rate of partner disclosure in PHIV youth, and highlights the need for a comprehensive guideline for HIV disclosure to sexual partners.
A Study of Cutting Strategy in Single-Point Diamond Turning of Micro V-Groove Patterns on Precision Roller Drums (2014)

This paper presents a study of cutting strategies on the surface generation in single-point diamond turning of micro V-groove patterns on precision roller drums. An aluminium precision roller drum with a diameter 250mm and 100 long was diamond turned with a V-groove pattern. A series of cutting experiments were designed to study the effect of the variation of various cutting parameters and cutting tool paths on the surface quality in diamond turning of the precision roller drum. The parameters under investigation included the depth of cut, number of steps and the depth for each cut when diamond turning V-grooves on the cylindrical surface of a workpiece. The measurement result indicates that the surface quality of V-grooves machined on the precision roller drums is affected by cutting strategies. The optimal cutting strategy for machining a V-groove pattern on a precision drum with 5µm depth was obtained.