gebhart/patrepeval huggingface dataset:
A Modified Vaccine Reduces the Rate of Large Injection Site Reactions to the Preschool Booster Dose of Diphtheria-Tetanus-Acellular Pertussis Vaccine (2005)

This preschool DTaP.IPV booster vaccination caused large local reactions in 1 in 5 children, with transient discomfort. With Tdap vaccine, such reactions were significantly fewer but not eliminated. A Tdap.IPV vaccine warrants study for routine use at 4-6 years of age.
Frequency reconfigurable phase modulated magnetoelectric sensors using ΔE effect (2017)

Magnetoelectric composites have shown promise in low power magnetic field sensing with responsive detection of low frequency fields through the modulation of electromechanical resonance by exploiting a nonlinearity in magnetoelastic properties (ΔE effect). There is also the as-of-yet unrealized potential of tuning this effect to further enhance the shift in resonant frequency of these devices. In the present work, the magnetic field sensitivity was modulated in a bending mode stress reconfigurable sensor through the application of uniaxial tensile stress, reaching up to 8% f0/mT. The minimum magnetic noise floor was determined by detecting the frequency shift using a phase locked loop circuit and was found to directly correspond to the maximum in magnetic field sensitivity that resulted from the ΔE effect.
New Correlations To Predict Non-Darcy Flow Coefficients at Immobile and Mobile Water Saturation (1994)

Abstract Several empirical correlations were developed relating the inertial, sometimes called the non-Darcy flow, coefficient (β) to permeability, porosity and water saturation. The correlations were developed using 407 data points taken on 24 cores over confining stress which was varied from 1000 psi to 5000 psi. The permeability range investigated was from 0.00197 to 1230 md. Previously published work1 on proppants extend the correlation to 350,000 md with a coefficient of determination of 98%. Water saturation has a significant effect on the coefficient. Confining stress effects are accounted for in the porosity and permeability values which decrease at elevated stress.
Measurement of the branching fraction ratioB(Bc+→ψ(2S)π+)/B(Bc+→J/ψπ+) (2015)

Using $pp$ collision data collected by LHCb at center-of-mass energies $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ and 8 TeV, corresponding to an integrated luminosity of $3\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$, the ratio of the branching fraction of the ${B}_{c}^{+}\ensuremath{\rightarrow}\ensuremath{\psi}(2S){\ensuremath{\pi}}^{+}$ decay relative to that of the ${B}_{c}^{+}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}$ decay is measured to be $0.268\ifmmode\pm\else\textpm\fi{}0.032(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}\phantom{\rule{0ex}{0ex}}0.007(\mathrm{syst})\ifmmode\pm\else\textpm\fi{}0.006(\mathrm{BF})$. The first uncertainty is statistical, the second is systematic, and the third is due to the uncertainties on the branching fractions of the $J/\ensuremath{\psi}\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ and $\ensuremath{\psi}(2S)\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ decays. This measurement is consistent with the previous LHCb result, and the statistical uncertainty is halved.
Neutral Flow Evolution in a Six-Kilowatt Hall Thruster (2011)

Peer Reviewed
Use of an EK-2 vector for the cloning of DNA from higher organisms. (1978)

A certified EK2 bacteriophage lambda vector, which is useful for cloning fragments of DNA from higher organisms, is described.
Direct inelastic scattering of N2 from Ag(111). I. Rotational populations and alignment (1988)

The rotational state populations and the quadrupole and hexadecapole alignment moments of N2 scattered off clean Ag(111) are determined by resonance enhanced multiphoton ionization (REMPI). The scattered N2 is found to be highly aligned with its rotational angular momentum vector J parallel to the surface. The degree of alignment is found to increase with increasing rotational excitation. We see less than perfect alignment at intermediate J values indicating that the surface is not completely flat. The alignment is relatively insensitive to incident energy, incident angle, or surface temperature Ts. However, the rotational state population distributions show pronounced rainbows for higher incident energy and/or more grazing exit angle. The rotational state distributions are found to depend strongly on the final scattering angle at low Ts; this effect is markedly reduced at higher Ts. Time-of-flight measurements are used to determine the average velocity of the scattered N2 as a function of rotational level. It is found that higher rotational excitation correlates with lower average velocity and that the incident molecules lose 20%–30% of their translational energy to the solid. No correlation is found between velocity and alignment. A comparison is made with published results for the NO/Ag(111) system and a variety of theoretical models found in the literature.
OPTIMAL FLOW PATH DESIGN OF A CANNULA (2004)

A critical component of most blood-wetted devices, which receives relatively minor attention, is the cannula that couples the device to the vasculature. Rotary blood pumps in particular require that the cannulae provide relatively uniform, undisturbed flow at their inlets. This requirement is however at odds with the anatomical constraints placed on the length and bend angle. The consequences are an undesirable angle of incidence for the blood flow upon the leading edge of the impeller blades decreasing efficiency and promoting thrombosis. This study utilizes computational fluid dynamics (CFD) to analyze and optimize the shape of an inflow cannula with an elliptical cross section. The cannula will be designed to fit the same constraints as the Streamliner Ventricular Assist Device (VAD). The shape of the cannula is described using Bezier curves to represent the centerline, the semi-major axis, the semi-minor axis, and the twist angle of the cross section. There are 5 parameters describing the centerline, and 3 for each of the other geometric features, along the angular position of the cannula. This allows for a wide range of flexibility for exploring the optimal design. Analyses were performed to investigate the sensitivity of the flow field to the shape, with particular interest in minimizing secondary flow, avoiding zones of separation and recirculation, while providing a uniform outlet velocity profile. The results produced both intuitive and counter-intuitive shapes. Ongoing work is investigating the unique entrance conditions experienced by the cannula, particularly the coupling of the cannula tip to the left ventricle.
Photonic Millimeter-wave generation and transmission system applicable to the high-frequency radio interferometers (2009)

In the field of high-frequency radio interferometer, Atacama Large Millimeter/sub-millimeter Array (ALMA), its highest receiving frequency reaches 950 GHz. To receive such high frequencies, a higher reference frequency is required (as much as over 100 GHz). To maintain signal coherency, this reference signal has to be highly stable. To address these issues, we have developed a new method to generate and transmit a reference signal in the form of frequency difference between two coherent light waves. The two transmitted optical signals require phase stability better than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-13</sup> (1 sec) in white phase noise in the Allan standard deviation.
Efficient ML Decoder for Quasi-orthogonal Space-Time Codes When Using QAM Constellation (2008)

The most attractive class of space-time codes comprises the full-rate orthogonal codes, such as the Alamouti code. These codes allow a simple individual decoding of each symbol of the space-time block, leading to a reduced complexity at the receiver. They exist however only for two transmit antennas. If one intends to increase the transmit diversity order, then it may either use a sub-unitary rate orthogonal code or use a full-rate quasi-orthogonal code in which the decoding is done in pairs of symbols. Unfortunately, the pair-wise decoding leads to a large search space of the Maximum Likelihood (ML) decoder, especially for high-rate constellations, such as 16-QAM or 64- QAM. This paper presents a less complex general ML decoding algorithm, with linear pre-processing phase, applicable for a class of quasi-orthogonal space-time codes with rectangular constellations (e.g. QPSK, 16-QAM, 64-QAM).
Complications from percutaneous-left ventricular assist devices versus intra-aortic balloon pump in acute myocardial infarction-cardiogenic shock (2020)

AMI-CS admissions receiving pLVAD had higher rates of complications compared to the IABP, with worse in-hospital outcomes in the cohort with complications.
Development of Graphene Based Inks for Deposition via Inkjet Printing for Sensing Application (2018)

In this work we investigate and optimize graphene based inks to achieve a stable and well-controllable jetting behavior using a DoD (Drop on Demand) inject printer which has all the required characteristics of a tool for mass production.
Multi-Constituent Cardiovascular Pills (MCCP) - Challenges and Promises of Population-Based Prophylactic Drug Therapy for Prevention of Heart Attack (2007)

Risk factors for atherosclerotic cardiovascular disease (CVD) are highly co-prevalent but poorly identified and treated. The Screening for Heart Attack Prevention and Education (SHAPE) Task Force from the Association for Eradication of Heart Attack (AEHA) has recently proposed a new strategy that recommends screening for subclinical atherosclerosis and implementing aggressive treatment of "vulnerable patients". The Task Force has also envisioned future developments that may shift mass screening strategies to mass prophylactic therapy. The "Polypill" concept, introduced by Wald and Law suggests a combination of statin, low-dose antihypertensives, aspirin and folic acid, in a single pill, taken prophylactically by high risk population can cut CVD event rates by as much as 80%. In this communication, we review the challenges and promises of such a strategy. "Polypill" is but one of an astronomical number of possible multiconstituent pills (MCCP). Attractive as the MCCP concept is, it lacks evidence from randomized controlled trials, and begs numerous questions about the credibility of the concept, the design and synthesis of such complex pills, pharmacokinetics, pharmacodynamics, bioequivalence, "class" vs. unique properties, interactions, evidence of clinical efficacy and safety, regulatory approval, post-marketing surveillance, prescription vs. over-the-counter use, responsibility for initiating and monitoring therapy, patient education, counterfeiting and importation, reimbursement, advertisement, patent protection, commercial viability, etc. If these issues are favorably addressed, MCCP stand to dramatically change the manner in which CVD is prevented particularly in developing societies. Notwithstanding, assuming low commercial interests, realizing the promises of MCCP will demand serious attention from national public health policymakers. The clinical and regulatory implications of population-based secondary prevention (which rely on a different evidence base, and in which entirely different risk-benefit and cost-effectiveness considerations apply) remain issues for active debate.
About the Need of Combining Power Market and Power Grid Model Results for Future Energy System Scenarios (2018)

The European power grid infrastructure faces various challenges due to the expansion of renewable energy sources (RES). To conduct investigations on interactions between power generation and the power grid, models for the power market as well as for the power grid are necessary. This paper describes the basic functionalities and working principles of both types of models as well as steps to couple power market results and the power grid model. The combination of these models is beneficial in terms of gaining realistic power flow scenarios in the grid model and of being able to pass back results of the power flow and restrictions to the market model. Focus is laid on the power grid model and possible application examples like algorithms in grid analysis, operation and dynamic equipment modelling.
Influence of laser shock peening on the residual stresses in additively manufactured 316L by Laser Powder Bed Fusion: A combined experimental–numerical study (2022)

Detrimental subsurface tensile residual stresses occur in laser powder bed fusion (LPBF) due to significant temperature gradients during the process. Besides heat treatments, laser shock peening (LSP) is a promising technology for tailoring residual stress profiles of additively manufactured components. A multi step process simulation is applied aiming at predicting the residual stress state after applying LSP to a cuboid shaped specimen manufactured by LPBF in two different building directions as well as comparing it with a post-build heat treatment. The validity of the numerical simulation is evaluated based on comparisons of residual stresses determined by incremental hole drilling technique within different stages of the multi step process: in the as-build condition, after subsequent heat treatment as well as after applying LSP to the as-build and heat treated specimens, showing overall a good experimental–numerical agreement throughout each of the process stages. Applying a heat treatment to the as-build LPBF sample at 700 °C for 6 h showed not to be effective in eliminating the surface tensile stress entirely, reducing the tensile residual stresses by 40%. However, the application of LSP on LPBF components showed promising results: LSP was able even to convert the detrimental near surface tensile residual stresses in the LPBF component into compressive residual stresses next to the surface, which is known to be beneficial for the fatigue performance.
The Gene for Enhancer Binding Proteins E12/E47 Lies at the t(1;19) Breakpoint in Acute Leukemias (1989)

The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies.
Potential Hazards of Implanted Devices for the Electrical Control of Tachyarrhythmias (1984)

Sensing difficulties are more common with antitachycardia devices employing atrial rather than ventricular leads, but the consequences are potentially more disastrous with ventricular leads. The problem may be magnified in that the spurious discharge from poor sensing is likely to be asynchronous. Worsening of arrhythmias during termination attempts cannot be totally avoided, but may be minimized if caution and expertise are applied to selection and testing. A device which can reliably terminate a tachyarrhythmia accelerated by a termination attempt is the safest.
DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells (2014)

Summary The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers robust biochemical analysis of the processes that underlie early germ cell formation. Here, we demonstrate that DAZL, a germ cell-specific RNA binding protein, is a robust PGC marker during in vitro germ cell development. Using Dazl-GFP reporter ESCs, we demonstrate that DAZL plays a central role in a large mRNA/protein interactive network that blocks the translation of core pluripotency factors, including Sox2 and Sall4, as well as of Suz12, a polycomb family member required for differentiation of pluripotent cells. Thus, DAZL limits both pluripotency and somatic differentiation in nascent PGCs. In addition, we observed that DAZL associates with mRNAs of key Caspases and similarly inhibits their translation. This elegant fail-safe mechanism ensures that, whereas loss of DAZL results in prolonged expression of pluripotency factors, teratoma formation is avoided due to the concomitant activation of the apoptotic cascade.
Electrodeposition of Cu on Ta-Based Layer (2007)

Ta substrates covered with nominal thicknesses of 1, 2.5, and physical vapor deposited (PVD) Cu seed were employed as substrates for Cu electrodeposition. Electroplating a thin, uniform Cu film on Cu seed less than in thickness is problematic using a typical acid electrolyte. A basic electrolyte was seen to be successful in electrodepositing a thin, continuous Cu film on all these substrates. Polarization curves show the nucleation of Cu from this electrolyte is influenced by the PVD Cu seed thickness, with the Cu seed exhibiting behavior similar to that obtained on thick PVD Cu seed. Chronoamperometry and SEM suggest that the presence of the PVD Cu on the Ta surface significantly affects the Cu nucleation process. High electrodeposited particle densities are achievable with the basic electrolyte on Cu PVD seeds in nominal thickness.
In Situ Imaging of Intracellular Calcium with Ischemia in Lung Subpleural Microvascular Endothelial Cells (1999)

We propose that generation of reactive oxygen species (ROS) during ischemia is associated with an increase in intracellular calcium ([Ca2+]i) in pulmonary capillary endothelial cells. We used an isolated rat lung model and epifluorescence microscopy to evaluate [Ca2+]i in subpleural microvascular endothelial cells in situ by ratio imaging of the fluorophores, Calcium Green and Fura Red (CG/FR). Lungs were ventilated continuously under control (continuously perfused) or global ischemia (no perfusion) and thus remained adequately oxygenated even with ischemia. Ischemia for 5 min led to increase in CG/FR, indicating increase in [Ca2+]i in endothelial cells in situ; CG/FR remained elevated during a subsequent 10 min of ischemia. Ca(2+)-free perfusion and gadolinium (100 microM) inhibited the increase in [Ca2+]i, while thapsigargin (250 nM) had no effect. These results indicate that increase in endothelial cell [Ca2+]i with ischemia was due to influx from the extracellular medium. Perfusion with N-acetyl-L-cysteine (20 mM) or diphenyleneiodonium chloride (10 microM) prevented the ischemia-mediated [Ca2+]i increase, suggesting a role for ROS in the Ca2+ changes with ischemia. Membrane depolarization by perfusion with high potassium (K+) or glyburide also resulted in increased [Ca2+]i whereas the K(+)-channel agonist cromakalim, inhibited ischemia-mediated Ca2+ influx. We conclude that increased ROS generation with 'oxygenated' lung ischemia is associated with influx of Ca2+ and an increase in endothelial cell cytosolic calcium concentration.
ChemInform Abstract: Synthesis of a Fluorogenic Cyclooctyne Activated by Cu‐Free Click Chemistry. (2012)

Abstract The coumarin‐conjugated cyclooctyne coumBARAC (X) is only weakly fluorescent.
Correlation of peripheral blood markers of DNA damage and immune response with chemoradiation response in patients with locally advanced rectal cancer. (2019)

e15109 Background: Approximately 60% of newly diagnosed rectal cancers are locally advanced. The standard of care for these malignancies is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. Unfortunately, only approximately 20% of patients experience a complete response, but all are at risk for toxicity. There are no biomarkers to predict who will derive the greatest benefit from CRT. We hypothesized that inherent DNA damage recognition and repair (DNA-DRR) capacity contributes to CRT response in rectal cancer. Methods: We used primary peripheral blood lymphocytes (pPBLs) from rectal cancer patients to study differences in DNA-DRR capacity. The blood samples used were either drawn prior to nCRT or post a standard course of ~5.5 weeks of nCRT. We used immunofluorescence and Luminex-based multianalyte approaches to study DNA-DRR capacity in pPBLs. To determine if the tested biomarkers correlated with CRT response, we segregated patients by neoadjuvant rectal (NAR) score, a validated surrogate endpoint in rectal cancer. Results: Using pPBLs, we found that a subset of patients had elevated phosphorylated histone H2AX (γ-H2AX) foci, a well-described marker of DNA double strand breaks. We found that poor responders (PoR; NAR score &gt; 14; n = 21) had lower γ-H2AX foci then complete responders (CR; NAR score &lt; 1; n = 21) (P &lt; 0.0001, Kruskal-Wallis test). We also did not observe any significant differences in γ-H2AX foci from pPBLs drawn prior to CRT versus post nCRT (p = 0.519, n = 11, Wilcoxon rank sum test). Next, by multianalyte testing, we found that a combined score derived from six DNA-DRR markers (ATR, MDM2, phosphorylated forms of H2AX (γ), p53, Chk1, Chk2) strongly correlated with CR (p &lt; 0.001). Finally, by multianalyte testing, we also detected a serum signature of inflammatory markers that significantly correlated with CRT response (p &lt; 0.05). Conclusions: Our data suggest that rectal cancer patients who differ in their response to CRT differ in global, inherent DNA-DRR capacity, suggesting that DNA-DRR capacity in pre-treatment pPBLs can form the basis of a predictive biomarker. This predictive capacity may reflect underlying epigenetic or genetic differences, or inflammatory state. Validation and further development of this novel assay is warranted, as it has the capacity to substantially improve patient selection in an era with growing treatment options for these patients.
Geographic style maps for two-dimensional lattices (2022)

This paper develops geographic style maps containing two-dimensional lattices in all known periodic crystals parameterized by recent complete invariants. Motivated by rigid crystal structures, lattices are considered up to rigid motion and uniform scaling. The resulting space of two-dimensional lattices is a square with identified edges or a punctured sphere. The new continuous maps show all Bravais classes as low-dimensional subspaces, visualize hundreds of thousands of lattices of real crystal structures from the Cambridge Structural Database, and motivate the development of continuous and invariant-based crystallography.
Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model (2018)

These results suggest that GW-23B7, an anti-β-sheet conformational mAb humanized for clinical trials, may be an effective therapeutic agent for human AD.
Heterogeneous Enantioselective Catalysts: Strategies for the Immobilization of Homogeneous Catalysts (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Large Human YACs Constructed in a rad52 Strain Show a Reduced Rate of Chimerism (1994)

Current YAC libraries are plagued by a high frequency of chimeras--that is, clones containing fragments from multiple genomic regions. Chimeras are thought to arise largely through recombination in the yeast host cell. If so, the use of recombination-deficient yeast strains, such as rad52 mutants, might be expected to alleviate the problem. Here, we report the construction of megabase-sized human YACs in the rad52 strain MHY5201 and the determination of their rate of chimerism by fluorescence in situ hybridization analysis. Examination of 48 YACs showed a rate of chimerism of at most 8%, whereas YACs constructed in the wildtype host AB1380 showed a rate of about 50%. These results show that it is possible to significantly decrease the rate of YAC chimerism through the use of appropriate yeast host strains.