gebhart/patrepeval huggingface dataset:
Comprehensive analysis of the impact of single and arrays of through silicon vias induced stress on high-k / metal gate CMOS performance (2010)

As scaling becomes increasingly difficult, 3D integration has emerged as a viable alternative to achieve the requisite bandwidth and power efficiency challenges. However mechanical stress induced by the through silicon vias (TSV) is one of the key constraints in the 3D flow that must be controlled in order to preserve the integrity of front end devices. For the first time an extended and comprehensive study is given for the stress induced by single- and arrayed TSVs and its impact on both analog and digital FEOL devices and circuits. This work provides a complete experimental assessment and quantifies the stress distribution and its effect on front end devices. By using a combined experimental and theoretical approach we provide a framework that will enable stress aware design and the right definition of keep out zone and ultimately save valuable silicon area.
Cochlear amplification: A moderated discussion (2015)

The following is an edited transcript of a recorded discussion session on the topic of “Cochlear Amplification”. The discussion, moderated by the authors, took place at the 12th International Workshop on the Mechanics of Hearing held at Cape Sounio, Greece, in June 2014. All participants knew that the session was being recorded. In view of both the spontaneous nature of the discussion and the editing, however, this transcript may not represent the considered or final views of the participants, and may not represent a consensus of experts in the field. The reader is advised to consult additional independent publications.
Numerical Implementation of Interfacial Drag Force for One-Dimensional, Two-Way Bubble Tracking Method. (2000)

A two-way bubble tracking method, in which each bubble is individually tracked on the Lagrangian coordinates, is one of the most promising two-phase flow models to partly take the place of a fully-averaged two-fluid model. In this method, conservation equations on different coordinate systems must be solved simultaneously, so that construction of the phase coupling models becomes particularly important. In the present study, taking into account the downward liquid flow formed around a bubble rising in a vertical pipe and using the bubble shape function proposed by Trapp et al. at the same time, we developed simple phase coupling models for one-dimensional, two-way bubble tracking method. The calculated results of a single bubble rising in a circular pipe filled with stagnant liquid showed that the proposed model not only successfully mitigates the numerical fluctuation of the bubble rising velocity but also naturally predicts the effect of containing wall on the terminal bubble velocity; the present model would therefore be reasonable from both numerical and physical points of view. It was also revealed that the mean void fraction in bubbly two-phase flow is reasonably to be predicted if the effect of other bubbles on the downward liquid flow is appropriately evaluated.
Large-Scale Behavioral Data: Potential and Pitfalls (2015)

Over the last decade, the rise of web services has made it possible to gather traces of human behavior in situ at a scale and fidelity previously unimaginable. Large-scale behavioral data enables researchers and practitioners to detect adverse drug reactions and interactions, to understand how information diffuses through social networks, how people browse and search for information, how individual learning strategies are related to educational outcome, etc. Using examples from search, I will highlight how observational logs provide a rich new lens onto the diversity of searchers, tasks, and interactivity that characterize information systems today, and how experimental logs have revolutionized the way in which web-based systems are designed and evaluated. Although logs provide a great deal of information about what people are doing, they provide little insight about why they are doing so or whether they are satisfied. Complementary methods from observations, laboratory studies and panels are necessary to provide a more complete understanding of and support for search which is increasingly a core fabric of people’s everyday lives. The CHI community should lead the way in shaping best practices and policy in behavioral log studies.
MicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed (2018)

From the integrated analyses of differentially expressed miRNA-mRNA data, we were able to identify breast muscle specific miRNAs and their target genes whose concerted actions can contribute to rapid growth and higher feed efficiency in modern broiler chickens. This study provides foundation data for elucidating molecular mechanisms that govern muscle growth in chickens.
Knock-Down of PRAME Increases Retinoic Acid Signaling and Cytotoxic Drug Sensitivity of Hodgkin Lymphoma Cells (2013)

The prognosis for patients with Hodgkin lymphoma (HL) has improved in recent decades. On the other hand, not all patients can be cured with the currently established therapy regimes and this therapy is associated with several adverse late effects. Therefore it is necessary to develop new therapy strategies. After treatment of L-540 HL cells with 5'-azacytidine (5AC), we observed increased expression of the preferentially expressed antigen in melanoma (PRAME). In addition, we detected an increased resistance of 5AC-treated cells against cytotoxic drugs. We analyzed the influence of PRAME on cell survival of HL cells by knocking down PRAME in the chemotherapy resistant cell line L-428, a cell line that express PRAME at a high level. After knock-down of PRAME using vector based RNA interference we observed increased sensitivity for cisplatin, etoposide and retinoic acid. DNA microarray analysis of HL cells after PRAME knock-down indicated regulation of several genes including down-regulation of known anti-apoptotic factors. Increased retinoic acid signaling in these cells was revealed by increased expression of the retinoic acid metabolizing cytochrome P450 (CYP26B1), a transcriptional target of retinoic acid signaling. Our data suggest that PRAME inhibits retinoic acid signaling in HL cells and that the knock-down of PRAME might be an interesting option for the development of new therapy strategies for patients with chemo-resistant HL.
PHOTONIC CRYSTALS: Towards Large-Scale Integration of Optical and Optoelectronic Circuits (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Shanhui Fan and J. D. Joannopoulos, "PHOTONIC CRYSTALS: Towards Large-Scale Integration of Optical and Optoelectronic Circuits," Optics & Photonics News 11(10), 28-33 (2000) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
High-density optoelectronic interconnect using micromachined spring arrays (2001)

We report on a novel flip-chip packaging technology capable of interconnecting devices packed at very high density. The process utilizes micro-machined cantilevers for establishing electrical contact, where package assembly is performed at room temperature without solder. The cantilevers, called micro-springs, are fabricated by sputtering, masking, and releasing a stress-engineered conductive thin film on a quartz substrate. The film is patterned into electrical routing wires whose ends are released from the substrate. Upon release, the film stress forces the ends to curl up into compliant springs. Packages are formed by pressing the micro-springs against a set of device contact pads, much like probing pads using tungsten needle probes. The connections between springs and contact pads are anchored by an encapsulating acrylic adhesive. We utilize this packaging technology to interconnect 200-element arrays of independently addressable VCSELs with 4 micrometer-wide pads on 6 micrometer pitch to silicon CMOS driver chips with equally dense output lines. Tests show the technology produces good contacts with excellent robustness.
Site-specific analysis of protein S-acylation by resin-assisted capture (2010)

Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein undergoes acylation with a hydrophobic 16 carbon lipid chain. Although this modification is a well-recognized determinant of protein function and localization, current techniques to study cellular S-acylation are cumbersome and/or technically demanding. We recently described a simple and robust methodology to rapidly identify S-nitrosylation sites in proteins via resin-assisted capture (RAC) and provided an initial description of the applicability of the technique to S-acylated proteins (acyl-RAC). Here we expand on the acyl-RAC assay, coupled with mass spectrometry-based proteomics, to characterize both previously reported and novel sites of endogenous S-acylation. Acyl-RAC should therefore find general applicability in studies of both global and individual protein S-acylation in mammalian cells.
Vision salvage after resection of a giant meningioma in a patient with a loss in light perception (2008)

Clinical approaches to the surgical management of optic chiasm compression stress quick action, as several case series have demonstrated minimal vision restoration following aggressive decompression in patients presenting more than 3 days after the onset of blindness. The authors here report the case of a 48-year-old woman who presented with near-complete binocular vision loss but regained visual function following surgical removal of a giant planum-tuberculum meningioma, which was performed 8 days after a documented loss in light perception. The interval between the patient's vision loss and successful vision-restoring decompressive surgery is the longest recorded to date in the literature. This case shows the importance of aggressive decompression of mass lesions despite extended intervals of optic nerve dysfunction.
An Automatic Baseline Regulation in a Highly Integrated Receiver Chip for JUNO (2017)

This paper describes the data processing unit and an automatic baseline regulation of a highly integrated readout chip (Vulcan) for JUNO. The chip collects data continuously at 1 Gsamples/sec. The Primary data processing which is performed in the integrated circuit can aid to reduce the memory and data processing efforts in the subsequent stages. In addition, a baseline regulator compensating a shift in the baseline is described.
Two-dimensional nonimaging concentrators with inhomogeneous media: a new look (1985)

The theory of two-dimensional (2-D) nonimaging concentrators is reviewed. A method for designing 2-D concentrators with inhomogeneous media, in which the refractive-index distribution is an output, is given. This method allows one to choose the shape of the mirrors when they are needed. As a result of the method we obtain a concentrator with maximum theoretical concentration formed by the composition of triangles of three different indices of refraction. The edge-ray principle is proven under several specific assumptions.
Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design (2018)

Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a basis for understanding the co-evolutionary contest between HIV and the humoral immune system. Here, we describe the structural characterization of an apex-targeting antibody lineage and autologous clade A viral Env from a donor in the Protocol C cohort. Comparison of Ab-Env complexes at early and late time points reveals that, within the antibody lineage, the CDRH3 loop rigidifies, the bnAb angle of approach steepens, and surface charges are mutated to accommodate glycan changes. Additionally, we observed differences in site-specific glycosylation between soluble and full-length Env constructs, which may be important for tuning optimal immunogenicity in soluble Env trimers. These studies therefore provide important guideposts for design of immunogens that prime and mature nAb responses to the Env V2-apex.
Spatiotemporal Averagingmethod for Enhancement of Reverberant Speech (2007)

We present a reverberant speech enhancement algorithm which, operating on the linear prediction residual of spatially averaged multi- microphone observations, utilizes temporal averaging of neighbouring larynx cycles. The enhanced larynx cycles are used to design an equalization filter, which is applied in order to dereverberate both voiced and unvoiced speech. The DYPSA algorithm is employed and evaluated for larynx cycle segmentation of reverberant speech. Simulation results show reverberation reduction with up to 5 dB in terms of segmental signal-to-reverberant ratio and 0.34 in terms of normalized Bark spectral distortion score.
Fuzzy Control: Synthesis and Analysis (2000)

From the Publisher:
Fuzzy techniques are used to cope with imprecisions in processes. Examining the synthesis and analysis tools of a fuzzy control system, this book brings a unique perspective to a design method often criticized for notably lacking models, a systematic synthesis methodology, and analysis tools. With contributions from practicing engineers and respected researchers, readers will find a number of issues fundamental to fuzzy control, including fuzzy dynamical systems, robustness, stability, controllability, and sensitivity analysis.
Physiological changes during the adaptation of hybridoma cells to low serum and serum‐free media (1991)

Two murine hybridoma cell lines (167.4G5.3 and S3H5/gamma2bA2) were adapted to grow in low-serum and serum-free media by a weaning procedure. The changes in cell growth, metabolic, and antibody production rates with adaptation were examined using biochemical and flow cytometric analyses. After adaptation to a particular serum level, the short-term serum response of the cells was experimentally determined. Specific growth rates, glucose and glutamine uptake and lactate and ammonia production rates, and specific antibody production rates were evaluated from the data. For both cell lines, an improvement in cell growth was observed after adaptation, and both higher growth rates and higher cell concentrations were obtained. The specific glucose and glutamine uptake rates and the lactate and ammonia production rates changed insignificantly with adaptation. Conversely, changes in the specific antibody production rate of the two cell lines differed. Cell line 167.4G5.3 showed a loss in antibody productivity at low serum levels, while the S3H5/gamma2bA2 kept its original productivity in low-serum-containing media. The intracellular antibody content for S3H5/gamma2bA2 cells remained unaltered by adaptation, but a low antibody containing cell population appeared in the 167.4G5.3 culture. The loss of specific antibody productivity in this cell line was due to the appearance of this population.
The Frontotemporal Dementia versus Primary Psychiatric Disorder (FTD versus PPD) Checklist: A Bedside Clinical Tool to Identify Behavioral Variant FTD in Patients with Late-Onset Behavioral Changes (2018)

Although further prospective validation is required, the "FTD vs PPD Checklist" could provide a simple tool to improve diagnostic accuracy, particularly in non-specialized settings.
On the involvement of lipoic acid in .alpha.-keto acid dehydrogenase complexes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the involvement of lipoic acid in .alpha.-keto acid dehydrogenase complexesWilliam H. Rastetter, Julian Adams, John W. Frost, Larry J. Nummy, Jane E. Frommer, and Kenneth B. RobertsCite this: J. Am. Chem. Soc. 1979, 101, 10, 2752–2753Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://doi.org/10.1021/ja00504a055RIGHTS & PERMISSIONSArticle Views135Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (283 KB) Get e-Alertsclose Get e-Alerts
The Impact of COVID-19 on Cancer Care in the Post Pandemic World: Five Major Lessons Learnt from Challenges and Countermeasures of Major Asian Cancer Centres (2021)

Through addressing these five big questions, focused collaboration among members and with international organisations such as City Cancer Challenge will allow enhanced preparedness for future international emergencies.<br />.
Reflectarray based on concept of gradient refractive index (2010)

In this paper, a type of novel reflectarray based on the GRIN lens is proposed. Basic idea about the new reflectarray is carefully addressed in next section, and then initial simulated results are given in the following part.
Oral RNA Interference Therapy for Celiac Disease using a Polymeric Microsphere Formulation (2021)

Abstract Celiac disease is a chronic inflammatory condition characterized by activation of the immune system in response to deamidation of gluten peptides brought about by tissue transglutaminase-2 (TG2). Overexpression of interleukin-15 (IL-15) in the intestinal epithelium and the lamina propria leads to the dysregulation of the immune system, leading to epithelial damage. The goal of this study was to develop an RNA interference therapeutic strategy for celiac disease using a combination of TG2 and IL-15 gene silencing in the inflamed intestine. TG2 and IL-15 silencing siRNA sequences, along with scrambled control, were encapsulated in Nanoparticle-in-Microsphere Oral System (NiMOS) and administered in poly(I:C) mouse model of celiac disease. Single TG2 and IL-15 siRNA therapy as well the combination showed effective gene silencing in vivo. Additionally, it was found that IL-15 gene silencing alone and combination in NiMOS significantly reduced other proinflammatory cytokines. The tissue histopathology data also confirmed a reduction in immune cell infiltration as well as restoration of the mucosal architecture and barrier function in the intestine upon treatment. Overall, the results of this study show evidence that celiac disease can be potentially treated with an oral microsphere formulation using a combination of TG2 and IL-15 RNA interference therapeutic strategy.
New Insights into the Reaction Mechanism of Sodium Vanadate for an Aqueous Zn Ion Battery (2020)

Sodium vanadate (Na1+xV3O8 or NVO) has recently attracted significant interest as a potential cathode material for an aqueous Zn ion battery for its unique pillared framework facilitating Zn ion migration. Here, we performed a detailed study on reaction mechanisms of hydrated Na2V6O16·2H2O slabs and nonhydrated Na1.25V3O8 nanorods using transmission electron microscopy. Our initial observation reveals that the thin (30–50 nm) Na2V6O16·2H2O system successfully undergoes discharge with Zn ion insertion into the structure while thick (120–170 nm) Na1.25V3O8 allows Zn ion insertion only at the surface, signifying the importance of both the presence of water and the nanostructure thickness in determining the reaction mechanism of NVO. More in-depth analysis of these two systems revealed the irreversible formation of the stable byproduct phase Zn3Nax(OH2)V2O7 (ZNVO), which likely evolved through a Zn-ion redox reaction, contributing to overall cell performance. Eventually, the entire discharge/charge process appears to become bifurcated, consisting of primary (Zn redox in NVO) and secondary (Zn redox in ZNVO) reactions, where their relative contribution to overall cell capacity changes with continued cycling. Our study provides a fresh insight into the morphology- and hydration-dependent reaction mechanisms of NVO and their implications on the electrochemistry.
Supplementary Figure 2 from Myeloid Expression of Adenosine A<sub>2A</sub> Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment (2023)

&lt;p&gt;Supplementary Figure 2. Myeloid deletion of &lt;i&gt;Adora2a&lt;/i&gt; increases lung infiltration of NK cells and antigen specific T cells in mice with melanoma.&lt;/p&gt;
Inhibition der Signaltransduktion von Toll-like-Rezeptoren durch Annexin 1 auf der Oberfläche apoptotischer Zellen (2009)

Apoptotische Zellen entstehen kontinuierlich im Rahmen der Entwicklung und Gewebehomöostase multizellulärer Organismen. Ihre Beseitigung erfolgt durch Phagozyten wie Dendritische Zellen (DC). Während die Aufnahme von Pathogenen DC aktiviert und zur Auslösung einer Immunantwort führt, wirkt die Phagozytose apoptotischer Zellen antiinflammatorisch. Dies dient dem Schutz des Organismus vor Immunreaktionen gegen „Selbst“-Antigene aus apoptotischen Zellen und damit vor Autoimmunerkrankungen. Durch welche Mechanismen apoptotische Zellen DC beeinflussen ist jedoch weitgehend ungeklärt. In dieser Arbeit wurde gezeigt, dass das Protein Annexin 1, das spezifisch auf der Oberfläche frühapoptotischer Zellen präsentiert wird, zu deren antiinflammatorischem Effekt beiträgt, indem es die Signaltransduktion von Toll-like-Rezeptoren (TLR) und somit die Aktivierung von DC hemmt. Die Modulation der Immunantwort durch apoptotische Zellen und insbesondere durch das Protein Annexin 1 wurde in in vitro-Experimenten mit DC oder DC-ähnlichen Zelllinien aus Maus und Mensch untersucht. Vorinkubation mit apoptotischen Zellen oder rekombinantem Annexin 1 führt zu einer verminderten Aktivierbarkeit der DC durch TLR-Liganden. Dies zeigt sich in einer reduzierten Sekretion proinflammatorischer Zytokine wie TNF, bei unveränderter Produktion des antiinflammatorischen Zytokins IL-10. Der Einfluss auf die Zytokinsekretion spiegelt sich in einer entsprechenden Regulation der Zytokin-mRNAs wider. Genexpressionsanalysen zeigen einen globalen negativ regulatorischen Einfluss von Annexin 1 auf die durch Lipopolysaccharid (LPS) induzierten proinflammatorischen Gene. Diese Effekte beruhen auf einer Inhibition der TLR-induzierten Signaltransduktion. Vorinkubation mit Annexin 1 bewirkt eine Reduktion der TLR-induzierten Phosphorylierung und Aktivierung von MAP-Kinasen sowie eine verminderte Aktivierung des Transkriptionsfaktors NF-kB. Die Regulation betrifft beide TLR-induzierte Signalwege, die von den Adaptormolekülen MyD88 bzw. TRIF abhängen: MyD88- und TRIF-abhängige Zytokine sind gleichermaßen inhibiert, und ein Effekt von Annexin 1 ist auch in MyD88-defizienten Mäusen zu beobachten. Dementsprechend beeinflusst Annexin 1 sowohl die Aktivierung über den ausschließlich TRIF-abhängigen TLR3 als auch die MyD88-abhängige Signaltransduktion von TLR2 und dem IL-1-Rezeptor. Die Stimulierbarkeit der DC über den nicht mit den TLR verwandten TNF-Rezeptor wird durch Annexin 1 ebenfalls vermindert, was auf eine umfassendere Inhibition proinflammatorischer Signaltransduktion hinweist. Experimente mit dem Translationsinhibitor Cycloheximid weisen darauf hin, dass der antiinflammatorische Effekt von einer durch Annexin 1 induzierten Proteinsynthese abhängt. Die Analyse der Annexin 1-vermittelten Effekte auf DC trägt zum Verständnis des Mechanismus bei, wie apoptotische Zellen das Immunsystem beeinflussen und möglicherweise zu peripherer Toleranz führen.