gebhart/patrepeval huggingface dataset:
SU-GG-T-66: Dosimetric Comparison between Contura MLB and MammoSite ML (2010)

Purpose: To quantify the dosimetric differences between Contura and Mammosite Multi-lumen (ML) plans for Accelerated Partial Breast Irradiation (APBI) Method and Materials: Twenty High Dose Rate (HDR) treatment plans using the new Mammosite ML balloon applicator were retrospectively generated for patients previously treated with HDR-APBI using Contura Multi Lumen Balloon applicator. ML lumens were placed by coincidence with the central lumen and oriented with an offset lumen closest to skin. Plans were optimized using the same constraints and had the same D95 target coverage. Dosimetric parameters from Contura and Mammosite plans were extracted and compared. These parameters included: max dose to skin, max dose to ribs, target coverage, conformity and dose homogeneity indices. Results: For large skin/rib to balloon distances, treatment plans with these two APBI techniques can achieve comparable coverage and dose homogeneity. V100, V150 and V200 were in the range of 0.2 to 3 cm3, 0.2 to 3.6cm3 and respectively 0.3 to 1.2cm3 typically lower for Contura. The ML conformity index was an average of 0.83 (min 0.71) versus 0.84 (min 0.74) for Contura. In constrained cases (small skin and rib distances), the maximum dose to skin was higher for ML, on average by 10% with a maximum of up to 20%. The differences for the maximum dose to closest ribs in these cases were smaller than 5%. Conclusion: For balloons placed at larger distances from skin and/or chest wall, the two balloon applicators achieve comparable target coverage, conformity and dose homogeneity. However, for smaller breast sizes, when the balloon becomes close to both skin and chest wall, Contura can achieve a better skin sparing than MammoSite, likely due to its lumen geometry. Conflict of Interest: DA, DT are consultants for SenoRx. Inc.
Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists (2023)

The mineralocorticoid receptor (MR) belongs to the steroid receptor subfamily of nuclear receptors. MR is a transcription factor key in regulating blood pressure and mineral homeostasis. In addition, it plays an important role in a broad range of biological and pathological conditions, greatly expanding its interest as a pharmacological target. Non-steroidal MR antagonists (MRAs) are of particular interest to avoid side effects and achieve tissue-specific modulation of the receptor. The 1,4-dihydropyridine (1,4-DHP) ring has been identified as an appropriate scaffold to develop non-steroidal MRAs. We report the identification of a novel series of 1,4-DHP that has been guided by structure-based drug design, focusing on the less explored DHP position 2. Interestingly, substituents at this position might interfere with MR helix H12 disposition, which is essential for the recruitment of co-regulators. Several of the newly synthesized 1,4-DHPs show interesting properties as MRAs and have a good selectivity profile. These 1,4-DHPs promote MR nuclear translocation with less efficiency than the natural agonist aldosterone, which explains, at least in part, its antagonist character. Molecular dynamic studies are suggestive of several derivatives interfering with the disposition of H12 in the agonist-associated conformation, and thus, they might stabilize an MR conformation unable to recruit co-activators.
Validating markerless pose estimation with 3D X-ray radiography (2022)

To reveal the neurophysiological underpinnings of natural movement, neural recordings must be paired with accurate tracking of limbs and postures. Here, we evaluated the accuracy of DeepLabCut (DLC), a deep learning markerless motion capture approach, by comparing it with a 3D X-ray video radiography system that tracks markers placed under the skin (XROMM). We recorded behavioral data simultaneously with XROMM and RGB video as marmosets foraged and reconstructed 3D kinematics in a common coordinate system. We used the toolkit Anipose to filter and triangulate DLC trajectories of 11 markers on the forelimb and torso and found a low median error (0.228 cm) between the two modalities corresponding to 2.0% of the range of motion. For studies allowing this relatively small error, DLC and similar markerless pose estimation tools enable the study of increasingly naturalistic behaviors in many fields including non-human primate motor control.
New structure of tunable wavelength-selective filters with a liquid crystal for FDM systems (1991)

To decrease the bandwidth of liquid-crystal Fabry-Perot interferometers (LC-FPIs), LC-FPIs having a double-layer cavity were devised where the intracavity consists of the LC layer and a glass layer. This filter is shown to have a very narrow bandwidth (full width at half maximum <10 GHz), low loss (4 dB), and a large tunability (9 nm). It is also shown to have the potential to select over 50 channels for FDM (frequency division multiplexing) systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Control law design for haptic interfaces to virtual reality (2002)

The goal of control law design for haptic displays is to provide a safe and stable user interface while maximizing the operator's sense of kinesthetic immersion in a virtual environment. This paper outlines a control design approach which stabilizes a haptic interface when coupled to a broad class of human operators and virtual environments. Two-port absolute stability criteria are used to develop explicit control law design bounds for two different haptic display implementations: the impedance display and admittance display. The strengths and weaknesses of each approach are illustrated through numerical and experimental results for a three degree-of-freedom device. The example highlights the ability of the proposed design procedure to handle some of the more difficult problems in control law synthesis for haptics, including structural flexibility and noncollocation of sensors and actuators.
On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay (2017)

The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here we present a modified MIB assay in which elution of bound proteins is facilitated by on-column trypsinization. We tested the modified MIB assay by analyzing extract from three human cancer cell lines treated with the cytotoxic drugs cisplatin or docetaxel. Using only three immobilized kinase inhibitors, we were able to detect about 6000 proteins, including ∼40% of the kinome, as well as other signaling, metabolic and structural proteins. The method is reproducible and the MIB-columns are re-usable without loss of performance. This makes the MIB assay a simple, affordable, and rapid assay for monitoring changes in cellular signaling.
Spatio-Temporal Rainfall Estimation from Communication Satellite Data using Graph Neural Networks (2022)

&amp;lt;p&amp;gt;Accurate precipitation estimation with high spatial and temporal resolution is key to many applications including weather forecast, flood monitoring and the prediction of natural hazards such as the recent extreme weather events around the world. While weather radars are able to monitor the spatio-temporal dynamics of precipitation, they are expensive and sparsely deployed around the world.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Alternatively, existing ground terminals used in satellite communication services (e.g. broadband internet) have shown the potential to function as accurate rain sensors. By analyzing the carrier-to-noise (C/N) data between the satellite and ground terminal, the rain-induced signal attenuation is estimated. The relationship between the attenuation and rain rate at millimeter-wave then allows computation of the latter. To tackle the difficulty of detecting rainy events and rain-induced attenuation, machine learning approaches are often used to learn from measurements of co-located rain gauges. These methods utilize dense or long short-term memory networks taking a temporal sequence of C/N values from one terminal as input to obtain the local rain rate. So far, most approaches have investigated each ground terminal as an independent sensor, fusing them only after rain rate estimation in order to create two-dimensional (2-D) rain maps. Since neighboring terminals are not considered, the rain estimates suffer from local inconsistencies and malfunctioning terminals are harder to detect which further impacts the accuracy.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;In this work, to achieve spatio-temporal consistency, we propose to estimate rainfall from a dense grid of ground terminals using graph-neural networks (GNN). By including neighboring terminal information directly in the estimation, rain rates are more consistent and malfunctions are easier to detect. We model local terminal neighborhoods in a GNN combined with one-dimensional convolutional neural networks taking the temporal sequence of C/N values of each terminal as input. The neural networks directly map C/N values to rain rates that are supervised during training using external rain gauge and weather radar data. After estimating rain rates for all terminals, 2-D rain maps are created by using ordinary kriging interpolation.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Initial results for January 12, 2021 storm event across the entire French metropolitan regions using 8000 active ground terminals indicate an improved average rain rate accuracy in comparison to weather radars. Furthermore, the resulting rain maps are significantly more spatio-temporally consistent compared to independent terminal approaches. These promising results allow rainfall estimation from satellite communication data to strongly complement the weather radar data or become a viable alternative in areas not covered with radars.&amp;lt;/p&amp;gt;
Erratum: “Precision cutting of nanotubes with a low-energy electron beam” [Appl. Phys. Lett. 86, 053109 (2005)] (2005)

͓DOI: 10
Data from Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Defining an adequate resection margin of colorectal cancer liver metastases is essential for optimizing surgical technique. We have attempted to evaluate the resection margin through a combination of histopathologic and genetic analyses.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We evaluated 88 samples of tumor margins from 12 patients with metastatic colon cancer who each underwent partial hepatectomy of one to six liver metastases. Punch biopsies of surrounding liver tissue were obtained at 4, 8, 12, and 16 mm from the tumor border. DNA from these biopsies was analyzed by a sensitive PCR-based technique, called BEAMing, for mutations of &lt;i&gt;KRAS, PIK3CA, APC&lt;/i&gt;, or &lt;i&gt;TP53&lt;/i&gt; identified in the corresponding tumor.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Mutations were identified in each patient's resected tumor and used to analyze the 88 samples circumscribing the tumor-normal border. Tumor-specific mutant DNA was detectable in surrounding liver tissue in 5 of these 88 samples, all within 4 mm of the tumor border. Biopsies that were 8, 12, and 16 mm from the macroscopic visible margin were devoid of detectable mutant tumor DNA and of microscopically visible cancer cells. Tumors with a significant radiologic response to chemotherapy were not associated with any increase in mutant tumor DNA in beyond 4 mm of the main tumor.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Mutant tumor-specific DNA can be detected beyond the visible tumor margin, but never beyond 4 mm, even in patients whose tumors were larger prior to chemotherapy. These data provide a rational basis for determining the extent of surgical excision required in patients undergoing resection of liver metastases. &lt;i&gt;Clin Cancer Res; 17(11); 3551–7. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Trapping, Detection, and Mass Measurement of Individual Ions in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrapping, Detection, and Mass Measurement of Individual Ions in a Fourier Transform Ion Cyclotron Resonance Mass SpectrometerJ. E. Bruce, X. Cheng, R. Bakhtiar, Q. Wu, S. A. Hofstadler, G. A. Anderson, and R. D. SmithCite this: J. Am. Chem. Soc. 1994, 116, 17, 7839–7847Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00096a046https://doi.org/10.1021/ja00096a046research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Environmentally Friendly Chemical Time Delays Based on Interrupted Reaction of Reactive Nanolaminates (2020)

Chemical time delays, devices that burn over specific times from under a millisecond to several seconds, are widely used in mining as well as civilian and military pyrotechnics and generally are composed of environmentally hazardous materials. Reactive nanolaminates are energetic materials composed of two or more reactants organized in an alternating layered structure, which may be fabricated with environmentally friendly components. Many traits of reactive nanolaminates are desirable for time delay applications, including their long shelf life and their highly repeatable and finely tunable reaction velocities. However, their reaction velocities are generally too high to be broadly applicable in chemical time delays. In this work, we use polymer mesh substrates to produce a constrained network of reactive particles, which reduce the reaction velocity of Al/Ni multilayers approximately 100× from a range of 2.8 to 7 m s–1 to a range of 7 to 90 mm s–1. This is accomplished via an interrupted reaction mechanism wherein individual particles on the coated mesh react rapidly but exhibit a delay before igniting neighboring particles due to the required heat transfer at the particles’ interfaces. We present the macroscale reaction velocities as a function of substrate composition and size, as well as reactive coating thickness and bilayer spacing. We employ high-speed videography to probe the ignition delays and finite element analysis simulations to aid in explaining the observed trends. Through selection of substrate and coating properties, time delays spanning a large range of delay times can be packaged into standard form factors.
Active photonics based on phase-change materials and reconfigurable nanowire systems (2020)

Metamaterials that derive their properties from the subwavelength structure of meta-atoms offer unprecedented flexibility for manipulating light-matter interaction. To promote the development of practical metadevices, considerable efforts have been made to achieve photonic metamaterials that exhibit an active response under external stimuli. The primary strategy is to incorporate active materials that possess variable refractive index into the design of metamaterials. Among the various active materials, phase-change materials have recently attracted particular attention due to their variation of material properties in a broad frequency band. On the other hand, as structures and geometric arrangement of building blocks (i.e., artificial atoms or meta-atoms) determine the properties of metamaterials, reconfigurable metamaterials based on mechanical tuning have also been intensively studied. Unlike most reported mechanically tunable metamaterials based on elastic and electromagnetic forces, directed self-assembly (DSA) of nanoparticles opens a new path for low-cost, large-area reconfigurable photonic systems. In this chapter, we present our findings on active photonics metadevices based on phase transition of vanadium dioxide (VO2) and reconfigurable nanowire assemblies. Our work shows the potential of the proposed metamaterial systems for applications ranging from electro-optical information process, storage, and display to energy-efficient smart windows.
Linear Transceiver Design With Per-Antenna Power Constraints in Full-Duplex Multi-User MIMO Systems (2016)

We study a mean-squared-error-based linear transceiver design problem in a multiple-input multiple-output cellular system with a full-duplex base station serving multiple half-duplex uplink and downlink users simultaneously under the practical per-antenna power constraints. First, an iterative nonlinear Gauss-Seidel type algorithm updating the beamformer of each transmit antenna using simple closed-form expressions is proposed. Then, a lower complexity design is proposed based on alternating direction method of multipliers.
Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications (2008)

4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The compound is rapidly metabolized systemically, thereby reducing the risk of unwanted systemic side effects due to its primary pharmacology. (-)- 6a was tested negative in the 3T3 NRU assay, validating our rationale that reduction of conjugation might reduce potential phototoxicity.
Gene nadA, Encoding Quinolinate Synthetase, Is Located on the Cyanelle DNA from Cyanophora paradoxa (1991)

Sequencage du gene nadA et sa localisation sur l'ADN plasmidial circulaire de l'algue micellulaire
Influence of electrode, buffer gas and control gear on metal halide lamp performance (2005)

In this paper the influence of electrode composition, buffer gas fill pressure and control gear on the performance of metal halide lamps is investigated. It is shown that pure tungsten electrodes improve lumen maintenance and reduce voltage rise over lamp life. An optimum buffer gas fill pressure condition is discovered which allows for reduced electrode erosion during lamp starting as well as under normal operating conditions. Use of electronic control gear is shown to improve the performance of metal halide lamps.
Electrospun Biomimetic SF/PCL Tympanic Membrane Implant: Experimental Study of Material Design, Acousto-Mechanical Properties and Biocompatability (2021)

Introduction Electrospun fiber membranes made of silk-fibroin (SF) and synthetic poly(caprolactone) (PCL) have a high potential to mimetic natural collagen fiber morphologies of the tympanic membrane (TM). In this work, experimental investigations on material design, acousto-mechanical properties and biocompatibility were performed to develop a biomimetic SF/PCL TM implant based on our previous simulation results.
A RANDOMISED CONTROLLED TRIAL COMPARING ACCELERATED DISCHARGE WITH STANDARD CARE AFTER UNICOMPARTMENTAL KNEE ARTHROPLASTY (2005)

Introduction and Aims Unicompartmental knee arthroplasty (UKA) is appropriate for one in three osteoarthritic knees requiring replacement. An accelerated protocol enables patients undergoing UKA to be discharged within 24 hours of surgery. Before such an approach is universally accepted it must be safe, effective and economically viable. A study was performed to compare the new accelerated protocol with current standard care in a state healthcare system. Method A single blind RCT design was used. Patients eligible for UKA were screened for NSAID tolerance, social circumstances and geographical location before allocation to either an accelerated recovery group (Group A) or a standard non accelerated group (Group S). The accelerated protocol included dedicated pain management and discharge support. Primary outcome was the Oxford Knee Assessment at 6 months post operation, compared using independent t tests. Pain, range of movement and incidence of complications were also recorded by assessors blind to group allocation. Cost effectiveness was calculated in quality life adjusted years (QLAY) using the Euroqual instrument. The study power was sufficient to avoid type 2 errors. The study was supported by a NHS Regional RD one infection (group S) and one manipulation for poor movement (group A). The cost per QLAY for the new protocol was 59% of the standard care. Conclusion The new protocol allows for safe accelerated discharge from hospital after UKA. The approach is cost effective and should help to increase the throughput of patients who require knee replacement.
Guest Editorial: Multi-Band Optical Networks (2022)

The papers in this special section focus on multi-band optical networks. The papers introduce the key challenges, trends, and innovations. Current deployed networks are reaching the saturation of their capacity with the continuous bandwidth demand increase. However, the installation of new infrastructures or fibers requires high investments from network operators. Thus, alternative solutions to cope with the enormous bandwidth demand are needed. Currently, single-mode fibers (SMF) are mainly used in the C band, where SMFs present the minimum attenuation. The exploitation of other bands (e.g., L, S, E and O) may be an effective solution for network upgrade while postponing the installation of new fibers. As L-band technologies are widely deployed today, there is a rising interest in considering other optical bands (e.g., S and E) in the following years to scale capacity. Multi-band (MB) optical networking is therefore feasible considering that many of the currently deployed fibers (e.g., G.652.D fibers) do not present the absorption peak (occurring mainly in the E band).
Optical force on a pair of concentric spheres in a focused laser beam: ray-optics regime (2012)

The photon stream method is used to derive the optical force on a pair of concentric spheres in a focused beam. The effects of the differences in refractive index and relative size between the inner and outer spheres on the optical force are evaluated. In addition, the effects of total internal reflection at the interface between the inner and outer spheres are examined. Computational results are compared with previous findings. The present method can be applied to arbitrary intensity distributions of the laser beam.
Corrigendum: Comparative Analysis of Human Epidermal and Peripheral Blood γδ T Cell Cytokine Profiles (2014)

Ann Dermatol Vol. 26, No. 3, 2014

http://dx.doi.org/10.5021/ad.2014.26.3.308

In this paper, the ACKNOWLEDGMENT was given incorrectly. The authors have supplied the following corrected version of ACKNOWLEDGMENT.

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. HN10C0009) and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2012R1A1A1015784). This study was conducted under a research agreement with AmorePacific Corporation, Republic of Korea.

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