gebhart/patrepeval huggingface dataset:
Mid-infrared germanium photonic crystal cavity (2017)

The mid-infrared (MIR) spectral range holds significant potential for spectroscopic and sensing applications because it encompasses the fingerprint region that unveils the vibrational and rotational signatures of molecules. CMOS-compatible on-chip devices that can achieve strong light-matter interaction in the entire fingerprint region are considered a promising way for such applications, but remain unprecedented. Here we present an on-chip MIR germanium photonic crystal cavity that covers the entire fingerprint region. This is made possible by harnessing a homemade air-cladding germanium platform. Our MIR device creates a new avenue toward integrated nonlinear optics and on-chip biochemical sensing in the fingerprint region.
Influence of Additives of Carbon Nanotubes and Oxide Nanofibers on Mechanical Properties of Aluminum Composite (2019)

Composite material with aluminum matrix reinforced by carbon nanotubes (CNT) and oxide nanofibers (NF) was made by powder metallurgy method. Powder mixtures were made by low energy milling on drum ball mill. Composite samples were manufactured by spark plasma sintering system. Microstructure analysis showed agglomeration of CNT and NF in composite materials. Correlation between flexural strength and unit mass of composites was revealed. Nevertheless, the use of low energy milling allows minimizing the damage of carbon nanotubes and oxide nanofibers during the preparation of mixtures. From this point of view it is suitable for making composites with high elastic modulus. It was shown that addition of 5-12%wt of CNT can increase flexural modulus by 30-189%. Also was shown that addition of 5%wt of oxide nanofibers increase flexural modulus by 78%
Toward a Neuroscience of Social Resonance (2016)

Abstract We describe a new area in neuroscience research focused on understanding how resonant neural patterns, within and between brains, enable human social intelligence. Thriving in the social world means accurately perceiving social cues and responding appropriately. Recent scientific discoveries suggest that high social intelligence requires rapid information processing likely enabled by resonance at several levels of computation. Here we discuss three of these levels: resonance across sensory maps, resonance across perception-production circuitry, and resonance across brains. This capacity for resonance helps explain why music moves us, how we can feel empathy for another’s pain, and when and with whom we are likely to form close social ties.
Transmission torque linearization of quadruped robot with a two-joint simultaneous drive mechanism for gravity compensation (2015)

This paper proposes a transmission torque linearization method for a leg robot using bi-articular simultaneous drive mechanism. A planetary gear is the primary mechanism of a bi-articular simultaneous drive system. Energy consumed for walking is reduced by the use of bi-articular muscles. However, the planetary gear causes a torque transmission loss in the leg robot system. The proposed method linearizes the nonlinear torque transmission by using a disturbance observer and the estimated self-weight disturbance torque. The experimental results point out that the proposed method linearizes the transmission torque.
A novel 2,18-bridged biliverdin derivative (1993)

Base-catalysed dehydrohalogenation of a 3,18-bis(2-ohloroethyl)biliverdin 1 affords a novel 3-vinylbiliverdin 3 in which the 2- and 18-positions are bridged with a propano-tether; the structure of 3 has been established using single crystal X-ray and 1H nuclear Overhauser effect studies.
Distance distributions in ensembles of low-density parity-check codes (2002)

We derive expressions for the average distance distributions in eight ensembles of regular low-density parity-check codes using a collection of binary parity check matrices.
Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel (2017)

The sigma-1 receptor (σ1-R) and sigma-2 receptor (σ2-R) are potential drug targets for treatment of cancer, pain, depression, retinal degeneration and other neuronal diseases. Previous reports show that sigma-1 receptor modulates the activities of multiple channels. We are interested in possible sigma receptor modulation of Kv2.1, a K<sup>+</sup> channel abundant in retinal photoreceptors. We tested the effect of established sigma receptor ligands on Kv2.1 channels which were stably expressed in HEK293 cells. Surprisingly, σ1-R antagonists inhibited Kv2.1 currents in both wild type and σ1-R knockout HEK293 cells that we engineered using the CRISPR/Cas9 technology. Moreover, PB28, a σ1-R antagonist and also σ2-R agonist, inhibited Kv2.1 in σ1-R knockout cells, but this action was not blocked by the σ2-R antagonists that did not have an effect on Kv2.1. We also observed inhibition of electroretinogram by PB28 in wild type as well as σ1-R knockout mice. Thus, the results in this study indicate that the Kv2.1-inhibiting function of the sigma ligands is not sigma receptor dependent, suggesting a direct effect of these ligands on the Kv2.1 channel.
<title>Laser beam deflector based on a domain-inverted electro-optic polymeric waveguide prism array</title> (1999)

We report the demonstration of a compact laser-beam deflector based on electro-optic prisms formed within a thin-film polymer waveguide. We fabricate planar waveguides using a polymer that can be readily poled and cured through the simultaneous application of a poling voltage and heat. The index of refraction of each prism in the cascade, but not of the surrounding polymer, is modulated by the electro- optic effect through the application of a drive voltage. A laser beam, to be deflected, is coupled into and out of the planar waveguide by cylindrical lenses. The application of a drive voltage creates a sequence of prisms in the planar waveguide, which change the path of propagation of beam through the planar waveguide with a variable angle of refraction depending upon the voltage. The deflection efficiency is observed to be nearly 100 percent and the laser beam maintains its Gaussian intensity profile after propagating through the device.
Cover (2023)

Cover captions: Domains of Resilience in Older Adults. See the related article by Abadir et al., pages 2381–2392.
Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection (2016)

With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
3291-keV J/sup. pi. / = (25/2)/sup +/ level in /sup 205/Tl (1984)

A J/sup ..pi../ = (25/2)/sup +/ isomer in /sup 205/Tl has been observed using techniques of in-beam ..gamma..-ray spectroscopy and the /sup 204/Hg(t,2n)/sup 205/Tl reaction. The decay scheme firmly establishes the yrast levels: (J/sup ..pi../,E/sub x/ (keV)) (11/2)/sup -/, 1484.02; (15/2)/sup -/, 2054.57; (17/2)/sup -/, 2394.18; (19/2)/sup -/, 2551.56; and (25/2)/sup +/, 3290.7. A candidate for a 12/sup -/ state in /sup 204/Tl with the configuration (..pi..h/sub 11/2/ /sup -1/, ..nu..i/sub 13/2/ /sup -1/) is identified.
A Handheld Computer as Part of a Portable In Vivo Knee Joint Load-Monitoring System (2008)

In vivo measurement of loads and pressures acting on articular cartilage in the knee joint during various activities and rehabilitative therapies following focal defect repair will provide a means of designing activities that encourage faster and more complete healing of focal defects.It was the goal of this study to develop a totally portable monitoring system that could be used during various activities and allow continuous monitoring of forces acting on the knee. In order to make the monitoring system portable, a handheld computer with custom software, a USB powered miniature wireless receiver and a battery-powered coil were developed to replace a currently used computer, AC powered bench top receiver and power supply.A Dell handheld running Windows Mobile operating system(OS) programmed using Labview was used to collect strain measurements. Measurements collected by the handheld based system connected to the miniature wireless receiver were compared with the measurements collected by a hardwired system and a computer based system during bench top testing and in vivo testing. The newly developed handheld based system had a maximum accuracy of 99% when compared to the computer based system.
Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system (2020)

Thus far, NKG2D-CAR engineered lymphocytes represent the most advanced therapeutic approach utilizing the NKG2D system. Similarly to other tumor-targeting CAR approaches, NKG2D-CAR cells demonstrate powerful on-target activity, but may also cause off-tumor toxicities or lose efficacy, if NKG2DL expression by tumors is reduced. However, NKG2D-CAR cells also act on the tumor microenvironment curtailing its immunosuppressive properties, thus providing an independent therapeutic benefit. The potency of tumoricidal NKG2D-expressing lymphocytes can be further boosted by enhancing NKG2DL expression through small molecules and therapeutic antibodies inhibiting tumor-associated shedding of NKG2DL.
Correction to Asbestos and Zeolites: from A to Z via a Common Ion (2021)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Asbestos and Zeolites: from A to Z via a Common IonGlen ReidGlen ReidMore by Glen Reid, Sonja KlebeSonja KlebeMore by Sonja Klebe, Nico van ZandwijkNico van ZandwijkMore by Nico van Zandwijk, and Anthony M. George*Anthony M. GeorgeMore by Anthony M. Georgehttps://orcid.org/0000-0003-4691-8960Cite this: Chem. Res. Toxicol. 2021, 34, 6, 1694Publication Date (Web):May 21, 2021Publication History Published online21 May 2021Published inissue 21 June 2021https://pubs.acs.org/doi/10.1021/acs.chemrestox.1c00173https://doi.org/10.1021/acs.chemrestox.1c00173correctionACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views669Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-Alertsclose Get e-Alerts
Highly Efficient Near‐Infrared Electroluminescence up to 800 nm Using Platinum(II) Phosphors (2020)

Abstract Near‐infrared organic light‐emitting diodes (NIR OLEDs) enable many unique applications ranging from night‐vision displays and photodynamic therapies. However, the development of efficient NIR OLEDs with a low efficiency roll‐off is still challenging. Here, a series of new heteroleptic Pt(II) complexes ( 1 – 4 ) flanked by both pyridyl pyrimidinate and functional azolate chelates are synthesized. The reduced ππ * energy gap of the pyridyl pyrimidinate chelate, and strong intermolecular interaction and high crystallinity in vacuum‐deposited thin films engender strong intermolecular charge transfer transition including metal–metal‐to‐ligand charge transfer; thereby, exhibiting efficient photoluminescence within 776–832 nm and short radiative lifetimes of 0.52–0.79 µs. Consequently, nondoped NIR‐emitting OLEDs based on these Pt(II) complexes are fabricated, to which Pt(II) complexes 2 and 4 give record high maximum external quantum efficiency of 10.61% at 794 nm and 9.58% at 803 nm, respectively. Moreover, low efficiency roll‐off is also observed, among which the device efficiencies of 2 and 4 are at least four times higher than that of the best NIR‐emitting OLEDs recorded at current density of 100 mA cm −2 .
Low-loss Si_3N_4 arrayed-waveguide grating (de)multiplexer using nano-core optical waveguides (2011)

A 16-channel 200 GHz arrayed-waveguide grating (AWG) (de)-multiplexer is demonstrated experimentally by utilizing Si3N4 buried optical waveguides, which have 50 nm-thick Si3N4 cores and a 15 μm-thick SiO2 cladding. The structure with an ultra-thin core layer helps to reduce the scattering due to the sidewall roughness and consequently shows very low loss of about 0.4~0.8 dB/m. When using this type of optical waveguide for an AWG (de)multiplexer, there is no problem associated with gap refill using the upper-cladding material even when choosing a small (e.g., 1.0 μm) gap between adjacent arrayed waveguides, which helps to reduce the transition loss between the FPR (free-propagation region) and the arrayed waveguides. Therefore, the demonstrated AWG (de)multiplexer based on the present Si3N4 buried optical waveguides has a low on-chip loss. The fabricated AWG (de)multiplexer is characterized in two wavelength ranges around 1310 nm and 1550 nm, respectively. It shows that the crosstalk from adjacent and non-adjacent channels are about -30 dB, and -40 dB, respectively, at the wavelength range of 1310 nm. The Si3N4 AWG (de)multiplexer has a temperature dependence of about 0.011 nm/°C, which is close to that of a pure SiO2 AWG device.
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups (2019)

Factor XIa (FXIa) inhibitors are promising novel anticoagulants, which show excellent efficacy in preclinical thrombosis models with minimal effects on hemostasis. The discovery of potent and selective FXIa inhibitors which are also orally bioavailable has been a challenge. Here, we describe optimization of the imidazole-based macrocyclic series and our initial progress toward meeting this challenge. A two-pronged strategy, which focused on replacement of the imidazole scaffold and the design of new P1 groups, led to the discovery of potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitors. Moreover, pyridine-based macrocycle 19, possessing the phenylimidazole carboxamide P1, exhibited excellent selectivity against relevant blood coagulation enzymes and displayed antithrombotic efficacy in a rabbit thrombosis model.
Novel Approach for Improving Interface Quality of 4H-SiC MOS Devices with UV Irradiation and Subsequent Thermal Annealing (2013)

We report on the harmful impact of ultraviolet (UV) light irradiation on thermally grown SiO2/4H-SiC(0001) structures and its use in subsequent thermal annealing for improving electrical properties of SiC-MOS devices. As we previously reported [1], significant UV-induced damage, such as positive flatband voltage shift and hysteresis in capacitance-voltage curves as well as increased interface state density, was observed for SiC-MOS devices with thermally grown oxides. Interestingly, the subsequent annealing of damaged SiO2/SiC samples resulted in superior electrical properties to those for untreated (fresh) devices. These findings imply that UV irradiation of the SiO2/SiC structure is effective for eliciting pre-existing carbon-related defects and transforming them into a simple configuration that can be easily passivated by thermal treatment.
Housing for Wounded Warriors (2021)

The treatment of veterans with disabilities has a long history. Contemporary American practices reflect a mix of traditional policies, demands of an all-volunteer army and new paradigms in community integration. The U.S. military encourages soldiers with disabilities to remain in active duty by providing job accommodations, including accessible housing. The Wounded Warrior Home Project built two demonstration homes in Fort Belvoir, Virginia to learn how universal design strategies could improve housing for these service members.  Guided tours and semi-structured interviews were used to assess the effectiveness of the designs and identify shortcomings. Based on the interviews, recommendations were made to improve the design of future homes for active duty soldiers with disabilities and their families. Reflections on the origin, implementation and impact of the project offer new insights into housing for soldiers and veterans with disabilities and universal design as currently conceived.
An innovative technique for fiber-coupled laser diode arrays (2007)

A 40W one-cm laser diode array was coupled to a .22NA 200micron diameter optical fiber, using a compact monolithic 3-D waveguide based device, with 50% coupling efficiency. No auxiliary optical elements were used between the array and the coupler, or between the coupler and the optical fiber.
Effect of Reparation of Repeat Sequences in the Human α-Synuclein on Fibrillation Ability (2007)

The aggregation and fibrillation of alpha-synuclein has been implicated as a causative factor in the Parkinson's disease. The hexamer motif KTKEGV is found in each of the seven imperfect repeat sequences in the N-terminal half of alpha-synuclein. The motif is not fully conserved in the sixth and seventh repeats. We created mutants in which the motif was repaired to be fully conserved in either (Rep6 and Rep7) or both (Rep67) of these two repeats. The Rep6 and Rep67 mutants showed a greatly reduced propensity to aggregate and fibrillate while all three mutants showed greater resistance to HFIP-induced formation of the alpha-helix intermediate. Resistance to formation in the partially folded intermediate may repress the folding of alpha-synuclein, consequently interfering with the aggregation and fibril formation. These results demonstrated that KTKEGV repeats may have a significant role in keeping native unfolded status of alpha-synuclein.
Impact of Polarization Dependent Loss and Cross-Phase Modulation on Polarization Multiplexed DQPSK Signals (2008)

We investigated PolMux-RZ-DQPSK signal degradation modes due to PDL and XPM in WDM transmission with co-propagating NRZ signals. SNR degradation due to PDL and XPM-induced polarization dependent phase noise greatly impact transmission system.
Efficient High-Order Interaction-Aware Feature Selection Based on Conditional Mutual Information (2016)

This study introduces a novel feature selection approach CMICOT, which is a further evolution of filter methods with sequential forward selection (SFS) whose scoring functions are based on conditional mutual information (MI). We state and study a novel saddle point (max-min) optimization problem to build a scoring function that is able to identify joint interactions between several features. This method fills the gap of MI-based SFS techniques with high-order dependencies. In this high-dimensional case, the estimation of MI has prohibitively high sample complexity. We mitigate this cost using a greedy approximation and binary representatives what makes our technique able to be effectively used. The superiority of our approach is demonstrated by comparison with recently proposed interaction-aware filters and several interaction-agnostic state-of-the-art ones on ten publicly available benchmark datasets.
Eulerian/Lagrangian coupling procedure for three-dimensional vortical flows (1995)

A coupled Eulerian/Lagrangian method is presented for the reduction of numerical diffusion observed in solutions of 3D vortical flows using standard Eulerian finite-volume time-marching procedures. A Lagrangian particle tracking method, added to the Eulerian time-marching procedure, provides a correction of the Eulerian solution. In turn, the Eulerian solution is used to integrate the Lagrangian state-vector along the particles trajectories. While the Eulerian solution ensures the conservation of mass and sets the pressure field, the particle markers describe accurately the convection properties and enhance the vorticity and entropy capturing capabilities of the Eulerian solver. The Eulerian/Lagrangian coupling strategies are discussed and the combined scheme is tested on a constant stagnation pressure flow in a 90 deg bend and on a swirling pipe flow. As the numerical diffusion is reduced when using the Lagrangian correction, a vorticity gradient augmentation is identified as a basic problem of this inviscid calculation.
On-Line Thermal Barrier Coating Monitoring for Real-Time Failure Protection and Life Maximization (2005)

Under the sponsorship of the U. S. Department of Energy's National Energy Laboratory, Siemens Power Generation, Inc proposed a four year program titled, ''On-Line Thermal Barrier Coating (TBC) Monitor for Real-Time Failure Protection and Life Maximization'', to develop, build and install the first generation of an on-line TBC monitoring system for use on land-based advanced gas turbines (AGT). Federal deregulation in electric power generation has accelerated power plant owner's demand for improved reliability availability maintainability (RAM) of the land-based advanced gas turbines. As a result, firing temperatures have been increased substantially in the advanced turbine engines, and the TBCs have been developed for maximum protection and life of all critical engine components operating at these higher temperatures. Losing TBC protection can therefore accelerate the degradation of substrate components materials and eventually lead to a premature failure of critical component and costly unscheduled power outages. This program seeks to substantially improve the operating life of high cost gas turbine components using TBC; thereby, lowering the cost of maintenance leading to lower cost of electricity. Siemens Power Generation, Inc. has teamed with Indigo Systems, a supplier of state-of-the-art infrared camera systems, and Wayne State University, a leading research organization in the field of infrared non-destructive examination (NDE), to complete the program.
Carboxyhemoglobin and Its Correlation to Disease Severity in Cirrhotics (2007)

Although CO and CO-Hb production may be increased in the cirrhotic patient, in this study no correlation was found to disease severity as measured by the MELD score. Further studies are needed to assess the role of CO in other complications of cirrhosis including infection and circulatory dysfunction.
Resolving Nano Scale Recording Bits on Phase-Change Rewritable Optical Disk (2006)

We use a new imaging method to resolve the nano scale recording bits on phase-change rewritable optical disks. By this method, several kinds of nano scale recording bits on different phase-change optical disks can be clearly imaged without any painstaking or expensive procedures. With the conductive-atomic force microscopy (C-AFM) images of nano scale recording bits on phase-change materials, we can study the properties of phase-change recording layers and the recording bit formation mechanism comprehensively.