gebhart/patrepeval huggingface dataset:
Recommendation on Temporary IPv6 Interface Identifiers (2018)

This document specifies a set of requirements for generating temporary
addresses, and clarifies the stability requirements for IPv6
addresses, allowing for the use of only temporary addresses.
Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma (2005)

A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow-derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumor-free mice were able to resist a repeat challenge with the same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma.
Spectrum Sensing Prototype for Sensing ATSC and Wireless Microphone Signals (2008)

Spectrum sensing is the key enabler for dynamic spectrum access in the television (TV) bands as it can allow secondary networks to reuse spectrum without causing harmful interference to primary users. In this paper we describe a sensing prototype that has been developed to demonstrate robust sensing of TV signals as well as wireless microphone signals in the laboratory and field. We will present the algorithms as well as simulation, lab and field test results that validate the prototype's capability to identify these signals down to a level of -116 dBm.
Nanotechnology enabled platforms for trace detection of pharmaceuticals (2011)

The current research leverages a nanotechnology enabled sensor platform for highly sensitive detection of pharmaceuticals contaminants in water samples using electrochemical impedance spectroscopy. The sensor surface consists of lithographically patterned gold electrodes and is functionalized with anti-pharmaceutical antibodies. A nanoporous alumina membrane is placed over the sensor surface to achieve enhanced signal amplification. Erythromycin and Ibuprofen were successfully detected on the sensor in amounts as low as parts per quadrillion. The design has potential to be developed into portable diagnostic equipment, offering rapid, inexpensive and highly reliable detection of pharmaceuticals with applications in the assessment of water quality.
Polyimide/carbon Nanocomposites (2003)

The goal of this product is to design and characterize well-defined conductive nanocomposite materials. The materials will be composed of a polymer matrix composed of rigid-backbone polyimides, and will be filled with modified or unmodified multi-walled carbon nanotubes (MWNTs). The ultimate design of this project is to create composite materials with optical clarity and a high conductivity.
Highly Enantioselective Aza‐Baylis—Hillman Reaction in a Chiral Reaction Medium. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
REHABILITATING A ROAD SURFACE WITH A THIN BONDED OVERLAY OF STEEL-FIBER-REINFORCED CONCRETE (1995)

This article describes an experiment to resurface a concrete pavement with a thin bonded overlay of steel-fibre-reinforced concrete. Conducted in a Montreal suburb over a period of more than eight years, the experiment provided the basis for assessing the performance of this technique under a variety of test conditions. The efficacy of the approach was validated by monitoring the progress of a network of microcracks, which quickly stabilized; by assessing the bonding of the thin overlay with coring and thermography; and by carrying out a detailed study of fiber corrosion at the microcrack level, which revealed that fibres were mostly corrosion free.
Group velocity dependence of propagation losses in single-line-defect photonic crystal waveguides on GaAs membranes (2004)

Group velocity, vg, dependence of propagation loss in single-line-defect photonic crystal waveguides on GaAs membranes, and minimum loss as low as 2.5 dB/mm, are presented. When vg is reduced by a factor of 7, an additional loss is found to be only 5 dB/mm, thus proving a feasible usage of low vg.
Diagnostic utility of components in allergy to Anisakis simplex. (2012)

rAni s 1 is the major allergen of Anisakis and the target allergen when diagnosing allergy to Anisakis, rAni s 3 is not relevant when attempting to explain false-positive results.
Effects of Thermal Exposure on Properties of Al-Li Alloys (2002)

The objective of this investigation is to evaluate the effects of thermal exposure on the mechanical properties of both production mature and developmental Al-Li alloys
Gated and Near-Surface Diffusion of Charged Fullerenes in Nanochannels (2011)

Nanoparticles and their derivatives have engendered significant recent interest. Despite considerable advances in nanofluidic physics, control over nanoparticle diffusive transport, requisite for a host of innovative applications, has yet to be demonstrated. In this study, we performed diffusion experiments for negatively and positively charged fullerene derivatives (dendritic fullerene-1, DF-1, and amino fullerene, AC60) in 5.7 and 13 nm silicon nanochannels in solutions with different ionic strengths. With DF-1, we demonstrated a gated diffusion whereby precise and reproducible control of the dynamics of the release profile was achieved by tuning the gradient of the ionic strength within the nanochannels. With AC60, we observed a near-surface diffusive transport that produced release rates that were independent of the size of the nanochannels within the range of our experiments. Finally, through theoretical analysis we were able to elucidate the relative importance of physical nanoconfinement, electrostatic interactions, and ionic strength heterogeneity with respect to these gated and near-surface diffusive transport phenomena. These results are significant for multiple applications, including the controlled administration of targeted nanovectors for therapeutics.
Observing Nearby Nuclei on Paramagnetic Trityls and MOFs via DNP and Electron Decoupling (2022)

Dynamic nuclear polarization (DNP) is an NMR sensitivity enhancement technique that mediates polarization transfer from unpaired electrons to NMR-active nuclei. Despite its success in elucidating important structural information on biological and inorganic materials, the detailed polarization-transfer pathway from the electrons to the nearby and then the bulk solvent nuclei, and finally to the molecules of interest-remains unclear. In particular, the nuclei in the paramagnetic polarizing agent play significant roles in relaying the enhanced NMR polarizations to more remote nuclei. Despite their importance, the direct NMR observation of these nuclei is challenging because of poor sensitivity. Here, we show that a combined DNP and electron decoupling approach can facilitate direct NMR detection of these nuclei. We achieved an ∼80 % improvement in NMR intensity via electron decoupling at 0.35 T and 80 K on trityl radicals. Moreover, we recorded a DNP enhancement factor of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:mrow><mml:mi>ϵ</mml:mi> <mml:mrow></mml:mrow></mml:mrow> <mml:annotation>${\varepsilon{} }$</mml:annotation> </mml:semantics> </mml:math> ∼90 and ∼11 % higher NMR intensity using electron decoupling on paramagnetic metal-organic framework, magnesium hexaoxytriphenylene (MgHOTP MOF).
Regulation of expression of genes encoding digestive proteases in the gut of a polyphagous lepidopteran larva in response to dietary protease inhibitors (2004)

Abstract. Larvae of Helicoverpa armigera (Hübner), a polyphagous lepidopteran crop pest, adapt to the presence of protease inhibitors in their diet by differential regulation of multiple genes encoding digestive proteases. The time‐course of their response to dietary soybean Kunitz trypsin inhibitor (SKTI) involves several stages; an initial up‐regulation of all protease genes assayed (up to 12 h after exposure to inhibitor) is succeeded by a longer‐term down‐regulation of expression of specific genes that encode proteases most sensitive to the inhibitor, whereas genes encoding putative inhibitor‐insensitive proteases continue to be up‐regulated (after 24 h of exposure). Consequently, insect protease activity changes from being sensitive to the inhibitor, to being largely insensitive. The insect response is comparable in its timescale with that of the synthesis of protease inhibitors in the plant wounding response. SKTl causes similar effects on protease gene expression and gut protease activity when fed in diets containing casein or hydrolysed casein as sources of amino acid, suggesting that the insect response is not mediated through inhibition of digestive proteolysis. Soybean Bowman–Birk inhibitor, which has a broader range of inhibitory activity against gut proteases in H. armigera, but is a less effective inhibitor on an I 50 basis, proves to be a more effective antimetabolite than SKTI, but does not induce inhibitor‐insensitive protease activity because it causes a general up‐regulation of protease‐encoding genes. A possible mechanism to account for these different responses is discussed.
Max-Min Fair Transmit Precoding for Multi-group Multicasting in Massive\n MIMO (2017)

This paper considers the downlink precoding for physical layer multicasting\nin massive multiple-input-multiple-output (MIMO) systems. We study the max-min\nfairness (MMF) problem, where channel state information (CSI) at the\ntransmitter is used to design precoding vectors that maximize the minimum\nspectral efficiency (SE) of the system, given fixed power budgets for uplink\ntraining and downlink transmission. Our system model accounts for channel\nestimation, pilot contamination, arbitrary pathlosses, and multi-group\nmulticasting. We consider six scenarios with different transmission\ntechnologies (unicast and multicast), different pilot assignment strategies\n(dedicated or shared pilot assignments), and different precoding schemes\n(maximum ratio transmission and zero forcing), and derive achievable spectral\nefficiencies for all possible combinations. Then we solve the MMF problem for\neach of these scenarios and for any given pilot length we find the SE\nmaximizing uplink pilot and downlink data transmission policies, all in\nclosed-forms. We use these results to draw a general guideline for massive MIMO\nmulticasting design, where for a given number of base station antennas, number\nof users, and coherence interval length, we determine the multicasting scheme\nthat shall be used.\n
GRP-producing nerves control antral somatostatin and gastrin secretion in pigs (1987)

By immunohistochemistry, nerve fibers containing gastrin-releasing polypeptide (GRP)-like immunoreactivity were identified close to the somatostatin (SS)-producing cells of the gastric antral mucosa. We, therefore, studied the possible role of GRP in the control of antral SS secretion by use of isolated perfused pig antrum with intact vagus nerve supply. Electrical stimulation of the vagus nerves at 4 Hz increased the antral release of GRP up to 10-fold and increased SS output 2- to 3-fold. Atropine at 10(-6) M had no effect on these responses. Intra-arterial GRP increased SS secretion significantly at 10(-10) M and eightfold at 10(-8) M, whereas gastrin secretion was stimulated significantly at 10(-11) M and maximally at 10(-10) M and inhibited at 10(-8) M. Preperfusion with a GRP antagonist ([D-Arg1,D-Pro2,D-Trp7,9,Leu11]substance P) or Fab fragments of antibodies against GRP abolished the effects of vagus stimulation on gastrin and somatostatin output. Gastrin in concentrations up to 10(-7) M was without effect on SS secretion. We conclude that electrical stimulation of the vagus nerves increases antral SS gastrin secretion and that GRP is a likely transmitter.
Hot Electrons Remote Excitation and their Ultrafast Dynamics (2021)

Hot electron-based devices are quite promissing for ultrafast photodetection and to set off enhanced physicochemical reactions [1] . Controlling their generation at the nanoscale within plasmonic devices is a key for the future development of hybrid hot-electrons technologies. Indeed, Surface Plasmon-Polaritons (SPPs) can be exploited to confine light and enhance the number of excited hot carriers [2] . We aim at studying the excitation and dynamics of hot electrons, enhanced by plasmonics, with two different approaches.
An FEA/MATLAB based machine design tool for switched reluctance motors (2011)

Switched reluctance machine (SRM) has a simple and low cost construction owing to the concentrated windings on the stator, no permanent magnets or windings on the rotor. This rugged structure offers many advantages such as high speed, fault tolerant and reliable operation, wide constant power range, low inertia and low inrush currents. However, due to the single source of excitation and dependence of inductance profile on excitation current and rotor position, the mathematical model of SRM is highly nonlinear. Moreover, unlike many other electrical machines, the energy conversion capacity of SRM is greater when working under high magnetic flux densities. In case of SRM with higher number of rotor poles, stator and rotor pole arc angles are limited due to the smaller interpolar gap. Therefore, it's harder to adjust the dimensions of the machine to prevent high saturation at the poles. Considering the nonlinear behavior and design challenges with the higher number of rotor poles, an iterative process is necessary for an SRM design and finite element analysis (FEA) software are widely used to get the inductance and torque profile for the given dimensions. The performance of an SRM is also dependent on torque ripples, which is a function of turn-on and turn-off angles. These parameters cannot be calculated in FEA, because it requires the dynamic control of the phase currents according to rotor position. This paper proposes a MATLAB based design tool, which, for the given machine dimensions and parameters, calculates the geometry and automatically draws and simulates the machine model in FEA software. Moreover using those results, it performs a dynamic simulation in Simulink plots the load torque and phase current profiles and so manages the whole design process. The geometrical and electrical design equations are given and the graphical user interfaces of the design tool are introduced.
Synchronisation vocale et mouvement compensé en reconstruction pour une ciné IRM de la parole (2015)

L’imagerie dynamique du conduit vocal permet d’etudier et de modeliser la production de la
parole. La duree moyenne de chaque son est d’environ 80 ms. Le
mouvement de chaque articulateur, en particulier la langue, doit etre mesure
avec suffisamment de precision. Actuellement la fluoroscopie a rayon X est
utilisee cliniquement. L’IRM temps reel permet la visualisation directe des
mouvements articulatoires [1] mais reste limitee en resolution. La
synchronisation de l’IRM par un systeme acoustique est possible [2] mais
necessite l’execution de mouvements articulatoires avec une parfaite
reproductibilite. Dans ce travail nous proposons un dispositif optimise pour la
realisation d’une imagerie dynamique IRM de la parole avec une haute
resolution spatiale et temporelle. Il s’appuie sur l’utilisation conjointe d’un
microphone compatible IRM enregistrant la parole pendant l’acquisition IRM
et d’une reconstruction d’images synchronisees a posteriori incluant une
compensation du mouvement. Cette reconstruction permet une prise en
compte de la variabilite de repetition de la phrase lors de l’acquisition.
Crystallization Behavior of Copolymers of Isotactic Poly(1-butene) with Ethylene from Ziegler–Natta Catalyst: Evidence of the Blocky Molecular Structure (2019)

The crystallization and thermal properties of copolymers of isotactic poly(1-butene) (iPB) with ethylene (iPBEt) synthesized with a Ziegler–Natta catalyst and ethylene (E) content between 7 and 45 mol % are presented. The crystallization properties provide evidence of a multiblock molecular structure of these copolymers. The samples have been separated in two or three fractions by standard fractionation in boiling solvents. Samples with ethylene concentration lower than 16 mol % surprisingly crystallize in form II of iPB, and crystallization of polyethylene also occurs for the maximum ethylene content of 45 mol %. Even more surprising is the result that the melting temperature of crystals of any polymorphic form of iPB that crystallize in these samples do not depend on the ethylene concentration. This suggests that long crystallizable butene sequences are present even at high ethylene concentration. In all fractions, the chains are composed of multiblocks where the comonomers are segregated, with blocks characterized by long crystallizable butene sequences and blocks with shorter butene sequences. In the different fractions, the average length of butene sequences is nearly the same. The different fractions are featured by different amounts of the constituting blocks.
Identification of the metabolites of benzo[f]quinoline and benzo[h]-quinoline formed by rat liver homogenate (1983)

Benzo[f]quinoline and benzo[h]quinoline are widespread environmental pollutants which have been found to be mutagenic. The metabolism of benzo[f]quinoline and benzo[h]quinoline was investigated using a liver homogenate from Aroclor-pretreated rats. The metabolites of benzo[f]quinoline which were identified were 7,8-dihydroxy-7,8-dihydrobenzo[f]quinoline, 9,10-dihydroxy-9,10-dihydrobenzo[f]quinoline, 7-hydroxybenzo[f]quinoline, and benzo[f]quinoline-N-oxide. Metabolism studies on benzo[f]quinoline performed in the presence of the epoxide hydratase inhibitor, 3,3,3-trichloropropylene oxide, demonstrated that the formation of both of these dihydrodiols can be inhibited. The major metabolites of benzo[h]quinoline were identified as 5,6-dihydroxy-5,6-dihydrobenzo[h]quinoline and 7,8-dihydroxy-7,8-dihydrobenzo[h]quinoline. Benzo[h]quinoline-N-oxide was not detected as a metabolite. In the presence of an epoxide hydratase inhibitor, the major metabolites of benzo[h]quinoline were 5,6-epoxybenzo[h]quinoline and 7-hydroxybenzo[h]quinoline. The difference in the metabolism to N-oxides observed between benzo[h]quinoline and benzo[f]quinoline is consistent with previous observations in which sterically hindered aromatic ring nitrogen compounds such as benzo[h]quinoline are more resistant to N-oxide formation. The nitrogen atom of these aza-arenes with its lone pair of electrons has a significant influence on sites at which dihydrodiols are formed. The data suggest that the aromatic ring nitrogen of these azaphenanthrenes has an effect similar to that of a methyl substituent in directing their metabolic oxidation.
Efficient choroidal neovascularization reduction by Sleeping Beauty Transposon-mediated PEDF gene delivery in rat iris and retinal pigment epithelial cells by using a clinical electroporator (2018)

Fernandez, Patricia; Recalde, Sergio; Hernandez, Maria; Garcia-Garcia, Laura; Bezunartea, Jaione; Roberto Rodriguez, Juan; Marie, Corinne; Scherman, Daniel; Izsvak, Zsuzsanna; Kropp, Martina; Johnen, Sandra; Thumann, Gabriele; Garcia-Layana, Alfredo
Experimental verification of the efficiency/power-density (&#x03B7;-&#x03C1;) Pareto Front of single-phase double-boost and TCM PFC rectifier systems (2013)

Over the last decades, the converter systems performance has been substantially improved but the endeavor for highest possible performance, especially with respect to power density, efficiency, and costs remains the most important driver of present and future developments and research. In latest publications, comprehensive analytical models have been applied in optimization procedures to calculate the design parameters of single-phase AC-DC converter systems resulting in the highest performance concerning multiple objectives. In this paper, an experimental validation of this analytical design approach is provided based on four prototype rectifier systems with Power Factor Correction (PFC) which result from the optimization with respect to power density or efficiency of the mature double-boost bridgeless Continuous Conduction Mode (CCM) and the recently published interleaved totem-pole-based Triangular Current Mode (TCM) rectifier topology. All design details, such as power component values and EMIfilter structure as well as volume and losses distributions, are provided and the measurement results regarding efficiency, EMI standards, and input current quality (power factor and total harmonic distortion) allow the direct performance comparison of the investigated rectifier topologies. All four prototype systems comply with the EMI standard CISPR 22 class B and exhibit a high power factor and a low current THD. The recently published TCM-topology is beneficially applied to achieve a higher efficiency compared to the efficiency- and volume-optimized double boost CCM rectifier systems with a similar power density. With the loss-optimized TCM-prototype an extreme efficiency of 99.23 % at nominal input voltage and rated output power has been measured.
349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation (2023)

Small molecule DYRK1A inhibitors induce adult human beta cell proliferation and expand human beta cell mass. Harmine also enhances differentiation and function in human beta cells in vitro and in vivo, increasing expression of key beta cell genes. It is unknown whether this “pro-differentiation effect” is a feature of all DYRK1A inhibitors. We compared harmine, 2-2c, 5-Iodotubericidin (5-IT), GNF4877, INDY, CC-401 and Leucettine-41 at doses that maximally drive human beta cell proliferation. As anticipated, harmine, 2-2c and 5-IT all increased expression of PDX1, MAFA, NKX6.1, SLC2A2, PCSK1, MAFB, SIX2, SLC30A8, and ENTPD3. These effects were observed in normal human islets as well as in islets from donors with T2D. Surprisingly, in simultaneous experiments, the DYRK1A inhibitors GNF4877, INDY, CC-401 and Leucettine failed to induce these beta cell differentiation markers. The pro-differentiation effect of harmine was independent of DYRK1A inhibition: silencing DYRK1A in human islets induced beta cell proliferation, but had no effect on differentiation; harmine treatment in DYRK1A-silenced islets restored beta cell pro-differentiation effects. The pro-differentiation effect was also independent of NFAT signaling and DREAM Complex effects, since NFAT overexpression, or p130, p107, E2F4 and E2F5 silencing had no effect on beta cell differentiation. Similarly, silencing other known harmine targets (DYRK2, 3, 4, the CLK and HIPK family) had no effect on either human beta cell differentiation nor proliferation. In summary, harmine, 2-2c and 5-IT are unique among the DYRK1A inhibitor family in their simultaneous ability to enhance both beta cell proliferation and differentiation. While the beta cell proliferation is mediated by DYRK1A inhibition, the pro-differentiation effects of harmine, 2-2c and 5-IT are distinct, and unexplained in mechanistic terms. These considerations have important implications for DYRK1A inhibitor drug development. Disclosure P. Wang: None. K. Kumar: None. H. Liu: None. O. Wood: None. E. Karakose: None. L. Choleva: None. L. Lambertini: None. A. Garcia-Ocana: Consultant; Sun Pharmaceutical Industries Ltd. R.J. DeVita: None. A.F. Stewart: None.