gebhart/patrepeval huggingface dataset:
Metalloproteinase inhibition augments antitumor efficacy of the anti‐CD30 immunotoxin Ki‐3(scFv)‐ETA′ against human lymphomas in vivo (2004)

There is increasing evidence that the shedding of extracellular antigen domains impedes selective immunotherapy. One example is CD30, which is overexpressed on the surface of malignant lymphoma cells and has been identified as a promising target for antibody-based immunotherapy. However, CD30 is cleaved from the surface of target cells and the resulting soluble ectodomain (sCD30) is protecting the cells from antibody binding. Shedding can be inhibited by hydroxamate inhibitors of metalloproteinases such as BB-3644. We thus evaluated the influence of BB-3644 on the efficacy of the anti-CD30 single-chain immunotoxin Ki-3(scFv)-ETA'. In vitro, the addition of BB-3644 augmented the antitumor effect of Ki-3(scFv)-ETA' against Hodgkin-derived L540Cy cells by a factor of 2.75. Severe combined immunodeficiency (SCID) mice challenged with CD30-positive L540Cy cells were treated with the immunotoxin. One single nontoxic dose of BB-3644 increased the mean survival time of animals treated concomitantly with Ki-3(scFv)-ETA' to 93 days as compared with 35 days in the control (p = 0.0017). When BB-3644 was continuously delivered using subcutaneously implanted pumps, this effect was even more pronounced with no observed tumor growth in the animals within 200 days. Thus, concomitant application of metalloproteinase inhibitors might become clinically relevant in antibody-based immunotherapy against targets known to be shed from tumor cells.
How Does Cell-Free Massive MIMO Support Multiple Federated Learning\n Groups? (2021)

Federated learning (FL) has been considered as a promising learning framework\nfor future machine learning systems due to its privacy preservation and\ncommunication efficiency. In beyond-5G/6G systems, it is likely to have\nmultiple FL groups with different learning purposes. This scenario leads to a\nquestion: How does a wireless network support multiple FL groups? As an answer,\nwe first propose to use a cell-free massive multiple-input multiple-output\n(MIMO) network to guarantee the stable operation of multiple FL processes by\nletting the iterations of these FL processes be executed together within a\nlarge-scale coherence time. We then develop a novel scheme that asynchronously\nexecutes the iterations of FL processes under multicasting downlink and\nconventional uplink transmission protocols. Finally, we propose a\nsimple/low-complexity resource allocation algorithm which optimally chooses the\npower and computation resources to minimize the execution time of each\niteration of each FL process.\n
ChemInform Abstract: Stereoselective C‐C Bond Formation in Carbohydrates by Radical Cyclization Reactions. Part 6. Influence of the Conformation of Anomeric Radicals on the Stereoselectivity of Their Cyclization. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation (2018)

Flash nanoprecipitation (FNP) by fast mixing of drug-containing organic solvent and water in a microchamber is a powerful and scalable technology to produce solid drug nanoparticles with high payload. The embedded therapeutic drugs, however, are largely limited to hydrophobic small molecules. By transferring proteins into organic solvent via hydrophobic ion pairing, the scope of FNP applications is expanded. This platform technology is capable of producing protein nanoparticles with tunable sizes (from ≈30 nm to sub-micrometers), high-production scale (grams per hour), high drug loading efficiency (>90%), and excellent reproducibility, opening a new paradigm for formulation of biological pharmaceuticals. As a proof-of-concept, insulin nanoparticles are made to address a major medical challenge; oral administration. A relative insulin bioavailability of 13.2% is achieved, enabling sustained reduction of blood glucose levels in a diabetic rat model.
ChemInform Abstract: CHEMISTRY OF THE AMINO RADICAL IONS. A NEW CHAIN PROCESS OF THE PROTONATED N‐CHLORAMINES (1984)

Abstract Die Umsetzung von Amin‐Radikal‐Anionen, die aus N‐Chloraminen mit Fe(ll)‐Verbindungen hergestellt werden, wird untersucht.
No Free Charge Theorem: a Covert Channel via USB Charging Cable on Mobile Devices (2016)

More and more people are regularly using mobile and battery-powered handsets, such as smartphones and tablets. At the same time, thanks to the technological innovation and to the high user demands, those devices are integrating extensive functionalities and developers are writing battery-draining apps, which results in a surge of energy consumption of these devices. This scenario leads many people to often look for opportunities to charge their devices at public charging stations: the presence of such stations is already prominent around public areas such as hotels, shopping malls, airports, gyms and museums, and is expected to significantly grow in the future. While most of the time the power comes for free, there is no guarantee that the charging station is not maliciously controlled by an adversary, with the intention to exfiltrate data from the devices that are connected to it. In this paper, we illustrate for the first time how an adversary could leverage a maliciously controlled charging station to exfiltrate data from the smartphone via a USB charging cable (i.e., without using the data transfer functionality), controlling a simple app running on the device, and without requiring any permission to be granted by the user to send data out of the device. We show the feasibility of the proposed attack through a prototype implementation in Android, which is able to send out potentially sensitive information, such as IMEI, contacts' phone number, and pictures.
Enzymic synthesis of L-acetylcarnitine and citric acid using acetyl coenzyme A recycling (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic synthesis of L-acetylcarnitine and citric acid using acetyl coenzyme A recyclingSmita S. Patel, Hugh D. Conlon, and David R. WaltCite this: J. Org. Chem. 1986, 51, 14, 2842–2844Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/jo00364a052https://doi.org/10.1021/jo00364a052research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Carbon Nanostructures: Covalently Connected Carbon Nanostructures for Current Collectors in Both the Cathode and Anode of Li–S Batteries (Adv. Mater. 41/2016) (2016)

On page 9094, a 3D current collector made of carbon-nanotube forests, covalently connected to an ultrathin graphite foam by carbon–carbon bonds is described by H. X. Ji and co-workers. The 3D current collector renders a high-rate capacity of 860 mA h g−1 at 12 C for a Li–S cell assembled using these current collectors, with the cathode loaded with elemental sulfur and the anode loaded with lithium metal.
Access to α-Aminophosphonic Acid Derivatives and Phosphonopeptides by [Rh(P–OP)]-Catalyzed Stereoselective Hydrogenation (2020)

The hydrogenation of <i>N</i>-substituted vinylphosphonates using rhodium complexes derived from P-OP ligands <b>L1</b>, <i>ent</i>-<b>L1</b>, or <b>(</b><i><b>R,R</b></i><b>)-Me-DuPHOS</b> as catalysts has been successfully accomplished, achieving very high levels of stereoselectivity (up to 99% ee or de). The described synthetic strategy allowed for the efficient preparation of α-aminophosphonic acid derivatives and phosphonopeptides, which are valuable building blocks for the preparation of biologically relevant molecules.
Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals (2016)

The biosynthesis of enveloped viruses depends heavily on the host cell endoplasmic reticulum (ER) glycoprotein quality control (QC) machinery. This dependency exceeds the dependency of host glycoproteins, offering a window for the targeting of ERQC for the development of broad-spectrum antivirals. We determined small-angle X-ray scattering (SAXS) and crystal structures of the main ERQC enzyme, ER α-glucosidase II (α-GluII; from mouse), alone and in complex with key ligands of its catalytic cycle and antiviral iminosugars, including two that are in clinical trials for the treatment of dengue fever. The SAXS data capture the enzyme's quaternary structure and suggest a conformational rearrangement is needed for the simultaneous binding of a monoglucosylated glycan to both subunits. The X-ray structures with key catalytic cycle intermediates highlight that an insertion between the +1 and +2 subsites contributes to the enzyme's activity and substrate specificity, and reveal that the presence of d-mannose at the +1 subsite renders the acid catalyst less efficient during the cleavage of the monoglucosylated substrate. The complexes with iminosugar antivirals suggest that inhibitors targeting a conserved ring of aromatic residues between the α-GluII +1 and +2 subsites would have increased potency and selectivity, thus providing a template for further rational drug design.
Expression of Insectical Protease Inhibitors in Arizona Cotton (1993)

Insect damage impacts tremendously on the value of the Arizona cotton crop. As traditional pesticides become increasingly less useful, due to insect resistance and regulatory problems, new methods for insect control are needed. For these reasons, we engineered genes encoding protease inhibitors (PIs) from Manduca sexta (tobacco hornworm), for expression in cotton, with the hope that these inhibitors would have insecticidal activity. Transgenic plants containing PIs have been generated: 22 fertile lines of the duplicated 35S promoter anti-elastase, 4 fertile lines of the anti -chymotrypsin and 5 fertile lines of the anti -trypsin. Over 3,000 T-1 seeds have been collected and T-2 generation seeds are in production. Many crosses have been made into Delta Pine 16, 90 and 5415 respectively. No significant effect of the PIs on boll number or seed yield was observed. Insect tests have been conducted and the results indicate that plants expressing the protease inhibitors (PI's) have decreased emergence of whiteflies compared to control plants. We believe this research is a significant step towards a bio- pesticide producing Arizona cotton variety.
A novel blind interference cancellation receiver for LTE uplink SC-FDMA systems (2017)

With the increase of the cell loadings, the interference among the adjacent cells becomes severer acting as the limiting factor for the cell-edge user performance. In this regard, there have been many standard activities in 3GPP (3rd Generation Partnership Project) to mitigate the ICI (Inter-Cell Interference). The eNB (Enhanced Node-B)-centric ICI mitigation having its own limit, the recent approaches incorporate the interference cancellation of a dominant interference from the adjacent cell at the receiver. However, for the LTE (Long Term Evolution) uplink, the SC-FDMA (Single-Carrier Frequency Division Multiple Access) structure prohibited the eNB to use a similar interference cancellation scheme as for the OFDMA (Orthogonal Frequency Division Multiple Access) UE (User Equipment) receiver. In this paper, we propose a blind interference cancellation receiver for LTE eNB, which performs ICI cancellation blindly without prior information of the adjacent cell interferences. It is shown that the proposed blind interference cancellation receiver for SC-FDMA provides significant performance gain against the conventional receiver.
Query Portals: Dynamically Generating Portals for Web (2009)

Many informational web search queries seek information about named entities residing in structured databases. The information about entities that a user is seeking could be available from the structured database, or from other web pages. For example, consider an informational query such as [lowlight digital cameras]. A large structured database consisting of products may contain several products that are relevant for the user’s query. Surfacing a set of the most relevant products to the user and then enabling her to obtain more information about one or more of them would be very useful. Ideally, we would like a portal- like functionality which provides an overview of all relevant products, and further allows drill down on them. The need for structured data search is illustrated by the proliferation of vertical search engines for products, celebrities [2], etc. Current web search engines already federate queries to one or more structured databases containing information about named entities products, people, movies and locations. Each structured database is searched individually and the relevant structured data items are returned to the web search engine. The search engine gathers the structured search results and displays them along side the web search results. However, this approach does not enable a portal-like functionality due to two key limitations.
FlowBlaze: Stateful Packet Processing in Hardware (2019)

While programmable NICs allow for better scalability to handle growing network workloads, providing an expressive yet simple abstraction to program stateful network functions in hardware remains a research challenge. We address the problem with FlowBlaze, an open abstraction for building stateful packet processing functions in hardware. The abstraction is based on Extended Finite State Machines and introduces the explicit definition of flow state, allowing FlowBlaze to leverage flow-level parallelism. FlowBlaze is expressive, supporting a wide range of complex network functions, and easy to use, hiding low-level hardware implementation issues from the programmer. Our implementation of FlowBlaze on a NetFPGA SmartNIC achieves very low latency (in the order of a few microseconds), consumes relatively little power, can hold per-flow state for hundreds of thousands of flows, and yields speeds of 40 Gb/s, allowing for even higher speeds on newer FPGA models. Both hardware and software implementations of FlowBlaze are publicly available.
Management of Catheter-Related Thrombosis in Patients Undergoing Autologous Stem Cell Transplantation (2015)

The optimal management of catheter-related thrombosis (CRT) in patients undergoing autologous stem-cell transplantation (ASCT) remains poorly defined. We reviewed the management of catheter-related thrombosis in ASCT patients in our transplant unit over an 8-year period.
Multistep hierarchical self-assembly of chiral nanopore arrays (2014)

A series of simple hierarchical self-assembly steps achieve self-organization from the centimeter to the subnanometer-length scales in the form of square-centimeter arrays of linear nanopores, each one having a single chiral helical nanofilament of large internal surface area and interfacial interactions based on chiral crystalline molecular arrangements.
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists. [Erratum to document cited in CA117(23):234413y] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists. [Erratum to document cited in CA117(23):234413y]Kenneth A. Jacobson, Olga Nikodijevic, Xiao Duo Ji, Deborah A. Berkich, David Eveleth, Reginald L. Dean, Kenichiro Hiramatsu, Neal F. Kassell, Philip J. M. Van Galen, and Cite this: J. Med. Chem. 1993, 36, 21, 3218Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jm00073a026https://doi.org/10.1021/jm00073a026research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Encapsulation of Human-Bone-Marrow-Derived Mesenchymal Stem Cells in Small Alginate Beads Using One-Step Emulsification by Internal Gelation: In Vitro, and In Vivo Evaluation in Degenerate Intervertebral Disc Model (2022)

Cell microencapsulation in gel beads contributes to many biomedical processes and pharmaceutical applications. Small beads (<300 µm) offer distinct advantages, mainly due to improved mass transfer and mechanical strength. Here, we describe, for the first time, the encapsulation of human-bone-marrow-derived mesenchymal stem cells (hBM-MSCs) in small-sized microspheres, using one-step emulsification by internal gelation. Small (127−257 µm) high-mannuronic-alginate microspheres were prepared at high agitation rates (800−1000 rpm), enabling control over the bead size and shape. The average viability of encapsulated hBM-MSCs after 2 weeks was 81 ± 4.3% for the higher agitation rates. hBM-MSC-loaded microspheres seeded within a glycosaminoglycan (GAG) analogue, which was previously proposed as a mechanically equivalent implant for degenerate discs, kept their viability, sphericity, and integrity for at least 6 weeks. A preliminary in vivo study of hBM-MSC-loaded microspheres implanted (via a GAG-analogue hydrogel) in a rat injured intervertebral disc model demonstrated long-lasting viability and biocompatibility for at least 8 weeks post-implantation. The proposed method offers an effective and reproducible way to maintain long-lasting viability in vitro and in vivo. This approach not only utilizes the benefits of a simple, mild, and scalable method, but also allows for the easy control of the bead size and shape by the agitation rate, which, overall, makes it a very attractive platform for regenerative-medicine applications.
Cytokine and gene transcription profiles of immune responses elicited by HIV lipopeptide vaccine in HIV-negative volunteers (2013)

HIV-LIPO-5 vaccination elicited Th1 and Th2 memory precursor responses and a consistent modulation in gene expression. The response profile before vaccination suggests an adjuvant effect of the lipid tail of HIV-LIPO-5. Our combined immunogenicity analyses allowed to identify a specific signature profile of HIV-LIPO-5 and indicate that HIV-LIPO-5 could be further developed as a prime in heterologous prime-boost strategies.
Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges (2020)

Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs.
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies (2021)

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Our study demonstrates that the combination of non-competing antibodies in REGEN-COV provides protection against all current SARS-CoV-2 variants of concern/interest and also protects against emergence of new variants and their potential seeding into the population in a clinical setting.
Fine current harmonics suppression control for the input current of electrolytic capacitor-less inverter for IPMSM (2015)

This paper proposes a current harmonics control method for the input current of an electrolytic capacitor-less inverter for an interior permanent magnet synchronous motor (IPMSM). In general, an IPMSM has large spatial harmonics caused by the rotor structure. The back electromotive force (EMF) of an IPMSM contains harmonics and generates three-phase current harmonics. The three-phase current harmonics result in the input current harmonics of an electrolytic capacitor-less inverter because the power converter system has little energy storage on the DC-link. This paper analyzes an input current harmonics generation mechanism based on averaged DC-link current. The proposed control method that controls the input current harmonics is based on the analysis mechanism. The validity of the proposed method is confirmed through simulation and experimental results.