gebhart/patrepeval huggingface dataset:
A Novel Programming Technique to Boost Low-Resistance State Performance in Ge-Rich GST Phase Change Memory (2014)

In this paper, we examine the problem of the drift of the low-resistance state (LRS) in phase change memories based on C or N doped and undoped Ge-rich Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Sb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Te <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> . A novel procedure, named R-SET technique, is proposed to boost the SET speed of these innovative phase change materials by overcoming the decrease of crystallization speed caused by Ge enrichment. The R-SET technique allows, at the same time, an optimized SET programming of the memory cell and the reduction of the LRS drift with respect to standard SET procedures. A circuit that generates the desired R-SET pulse based on a time reference scheme is proposed and discussed.
Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles (2019)

Polymeric particles made up of biodegradable and biocompatible polymers such as poly(lactic-co-glycolic acid) (PLGA) are promising tools for several biomedical applications including drug delivery. Particular emphasis is placed on the size and surface functionality of these systems as they are regarded as the main protagonists in dictating the particle behavior in vitro and in vivo. Current methods of manufacturing polymeric drug carriers offer a wide range of achievable particle sizes, however, they are unlikely to accurately control the size while maintaining the same production method and particle uniformity, as well as final production yield. Microfluidics technology has emerged as an efficient tool to manufacture particles in a highly controllable manner. Here, we report on tuning the size of PLGA particles at diameters ranging from sub-micron to microns using a single microfluidics device, and demonstrate how particle size influences the release characteristics, cellular uptake and in vivo clearance of these particles. Highly controlled production of PLGA particles with ~100 nm, ~200 nm, and >1000 nm diameter is achieved through modification of flow and formulation parameters. Efficiency of particle uptake by dendritic cells and myeloid-derived suppressor cells isolated from mice is strongly correlated with particle size and is most efficient for ~100 nm particles. Particles systemically administered to mice mainly accumulate in liver and ~100 nm particles are cleared slower. Our study shows the direct relation between particle size varied through microfluidics and the pharmacokinetics behavior of particles, which provides a further step towards the establishment of a customizable production process to generate tailor-made nanomedicines.
Quantization and Training of Neural Networks for Efficient\n Integer-Arithmetic-Only Inference (2017)

The rising popularity of intelligent mobile devices and the daunting\ncomputational cost of deep learning-based models call for efficient and\naccurate on-device inference schemes. We propose a quantization scheme that\nallows inference to be carried out using integer-only arithmetic, which can be\nimplemented more efficiently than floating point inference on commonly\navailable integer-only hardware. We also co-design a training procedure to\npreserve end-to-end model accuracy post quantization. As a result, the proposed\nquantization scheme improves the tradeoff between accuracy and on-device\nlatency. The improvements are significant even on MobileNets, a model family\nknown for run-time efficiency, and are demonstrated in ImageNet classification\nand COCO detection on popular CPUs.\n
Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90 (2010)

Herein we show that San A-amide, a structurally unique molecule, influences a subset of cancer-related pathways involving Hsp90. We show that San A-amide specifically binds to the N-middle domain of Hsp90 allosterically disrupts the binding of proteins thought to interact with the Hsp90 C-terminal domain, while having no effect on an N-terminal domain client protein. This unique mechanism suggests that San A-amide is a potential tool for studying C-terminal binding proteins of Hsp90 as well as a promising lead in the development of new cancer therapeutics.
Identification of Room Acoustic Impulse Responses via Kronecker Product Decompositions (2022)

The identification of room acoustic impulse responses represents a challenging problem in the framework of many important applications related to the acoustic environment, like echo cancellation, noise reduction, and microphone arrays, among others. In this context, the main issues are related to the long length of such impulse responses and their time-variant nature. These raise significant difficulties in terms of the convergence rate, computational complexity, and accuracy of the solution. Recently, a decomposition-based approach was developed for the identification of low-rank systems, which can also be applied (to some extent) for the identification of acoustic impulse responses. This approach exploits the nearest Kronecker product decomposition of the impulse response and solves a high-dimension system identification problem using a combination of low-dimension solutions (provided by shorter filters), thus gaining in terms of both performance and complexity. Nevertheless, it does not consider the intrinsic nature of the room acoustic impulse responses, which contain specific components (e.g., early reflections and late reverberation) that can be very different in nature. In this paper, we propose an improved decomposition-based method (via the Kronecker product) that takes into account these specific components and processes them separately, in order to better exploit their important low-rank features. Following this approach, an iterative Wiener filter is firstly developed, followed by a recursive least-squares (RLS) algorithm designed in the same framework. Both solutions outperform the conventional benchmarks, i.e., the conventional Wiener filter and the RLS algorithm, respectively. Moreover, they achieve superior performances as compared to the recently developed versions based on the nearest Kronecker product decomposition, also owning lower computational complexities than their previous counterparts. Simulations are performed in the framework of acoustic echo cancellation and the obtained results support the performance features of the proposed algorithms.
Deformation Behavior of an Al 2 O 3 ─Y 3 Al 5 O 12 Eutectic Composite in Comparison with Sapphire and YAG (1993)

The relationship between a composite and its constituents with respect to high‐temperature deformation behavior was investigated using the Al 2 O 3 ‐Y 3 Al 5 O 12 (YAG) eutectic system. The eutectic is essentially a composite with sapphire and YAG as the two phases with a volume fraction of YAG of 0.45. The deformation behavior of the eutectic and those of single‐crystal sapphire and YAG were studied under identical conditions, using constant‐strain‐rate compression tests in air at 1530°C. The composite was also studied at 1650°C and compared with existing data on sapphire and YAG. The stronger YAG phase was found to reinforce the sapphire matrix at higher strain rates, but the composite crept faster than sapphire at lower strain rates. It is suggested using a simple semiempirical analysis that diffusional relaxation at the YAG‐sapphire interface boundaries may cause the inferior creep behavior at lower strain rates.
Instability of OTFT with Organic Gate Dielectrics (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
On Pornography (1993)

The policing of pornography remains a subject of widespread controversy. On Pornography provides a history of this policing and an understanding of the current debate. The authors show that obscenity
Mission profile based optimization of a synchronous-buck DC-DC converter for a Wearable Power System (2009)

A Wearable Power System (WPS) is a portable fuel-to-electrical energy converter that is carried on the body and is able to supply an average of 20 W for 4 days and has a total weight of less than 4 kg. Due to limited total weight of the system, each system part must have the highest efficiency to weight ratio. This paper presents the optimization of a synchronous buck DC-DC converter that is used to regulate the variable power source to a constant 14 VDC for the load. Higher switching frequency leads to smaller components and low weight, but at the same time, to higher losses that are compensated through additional fuel weight. If low switching frequency is applied, the weight of the converter will increase due to a larger inductor, but the power losses will be lower. Therefore, an optimal switching frequency should exist that results in the total weight of the DC-DC converter and additional fuel being a minimum. The paper first explains the proposed solution for WPS, the load pattern that is used to test the system and then the algorithm that decides on the number of converters to be used and how to find the optimal switching frequency. Additionally, two prototypes have been constructed. First prototype has nominal power of 20 W and is used in the analysis regarding the optimal number of converters. The second one has rated power of 200 W and it is built to support the conclusions based on the optimization process.
Preliminary evidence on the safety profile of BNT162b2 ( Comirnaty ): new insights from data analysis in EudraVigilance and adverse reaction reports from an Italian health facility (2021)

The first vaccine against SARS-CoV-2 made available in Italy has been BNT162b2, the two-dose mRNA-based vaccine developed by Pfizer-BioNTech. The ASST Fatebenefratelli-Sacco hospital is located in one of the areas most affected by the pandemic, and to date over 2000 healthcare professionals have been injected with both vaccine doses. We have collected all spontaneous safety reports in which BNT162b2 was designated as the possible cause. We also have carried out a descriptive analysis of reports submitted in EudraVigilance in the same time-frame and compared our findings with those observed in clinical trials. We have identified several new and unexpected adverse reactions that will be helpful for reviewing the safety profile defined in the Summary of Product Characteristics for this vaccine.
Future buffer based adaptation for VBR video streaming over HTTP (2015)

HTTP streaming has become a cost effective means for video delivery nowadays. To enable adaptivity to networks and terminals, a provider should generate multiple representations of an original video as well as the related signaling metadata. So far, most previous studies have just focused on the case of CBR (constant bitrate) video. In this paper, we propose a novel adaptation method for VBR (variable bitrate) video streaming. Based on a trellis representation to estimate future buffer levels, the proposed method can provide smooth video quality while avoiding buffer underflows. The experimental results show that our approach can perform effectively under drastic changes of both connection throughput and video bitrate.
High-Performance Supercapacitors Based on Poly(ionic liquid)-Modified Graphene Electrodes (2010)

We report a high-performance supercapacitor incorporating a poly(ionic liquid)-modified reduced graphene oxide (PIL:RG-O) electrode and an ionic liquid (IL) electrolyte (specifically, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide or EMIM-NTf(2)). PIL:RG-O provides enhanced compatibility with the IL electrolyte, thereby increasing the effective electrode surface area accessible to electrolyte ions. The supercapacitor assembled with PIL:RG-O electrode and EMIM-NTf(2) electrolyte showed a stable electrochemical response up to 3.5 V operating voltage and was capable of yielding a maximum energy density of 6.5 W·h/kg with a power density of 2.4 kW/kg. These results demonstrate the potential of the PIL:RG-O material as an electrode in high-performance supercapacitors.
Biochemical Analysis Using High-Resolution Magic Angle Spinning NMR Spectroscopy Distinguishes Lipoma-Like Well-Differentiated Liposarcoma from Normal Fat (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTBiochemical Analysis Using High-Resolution Magic Angle Spinning NMR Spectroscopy Distinguishes Lipoma-Like Well-Differentiated Liposarcoma from Normal FatJin-Hong Chen, Brian M. Enloe, Christopher D. Fletcher, D. G. Cory, and Samuel SingerView Author Information Department of Surgery Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts 02115 Francis Bitter Magnet Laboratory Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Department of Pathology Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts 02115 Department of Nuclear Engineering Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Cite this: J. Am. Chem. Soc. 2001, 123, 37, 9200–9201Publication Date (Web):August 25, 2001Publication History Received11 May 2001Revised3 August 2001Published online25 August 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/ja016182uhttps://doi.org/10.1021/ja016182urapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views249Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Cell physiology,Deconvolution,Lipids,Metabolism,Nuclear magnetic resonance spectroscopy Get e-Alerts
Neuronal Ca2+ Channels and Nicotinic ACh Receptors as Functional Targets of the Nootropic Nefiracetam (2001)

Abstract: Piracetam‐like nootropics (or cognitive enhancers) have been used for the treatment of various forms of dementia, including Alzheimer's disease. The underlying mechanisms of their actions, however, are largely unknown. Our recent studies have demonstrated that nefiracetam, a nootropic agent, can markedly enhance activities of neuronal L‐and N‐type (α 1B ) Ca 2+ channels as well as those of presynaptic nicotinic acetylcholine (ACh) receptors, thereby increasing neurotransmitter release. Aniracetam exerted a slight facilitatory effect on Ca 2+ channels, but no effect on nicotinic ACh receptors. Piracetam and oxiracetam have no such actions on Ca 2+ channels and nicotinic ACh receptors. It is suggested that inhibitory G‐proteins (Go/Gi) and protein kinase A (PKA) mediate the nefiracetam action on Ca 2+ channels, whereas protein kinase C (PKC) mediates the drug action on nicotinic ACh receptors. In the hippocampus of the rodent, nefiracetam induces a long‐lasting (&gt;4 h) facilitation of synaptic transmission. The ‘LTP‐like’ facilitation appears to result from activation of presynaptic nicotinic ACh receptors (and Ca 2+ channels as well) by nefiracetam. In conclusion, nefiracetam is distinguished from other nootropic agents for its preferential actions on both presynaptic Ca 2+ channels and nicotinic ACh receptors, and could therefore be of great therapeutic importance to the neurotransmission failure that contributes to the symptoms of Alzheimer's disease and associated disorders.
Vertical interconnect measurement techniques based on double-sided probing system and short-open-load-reciprocal calibration (2011)

This work develops a double-sided probing system and calibration method for measuring the S-parameters of vertical interconnects at the wafer, package and socket level. The applicable device under test (DUTs) include through silicon vias (TSVs), plated through holes (PTHs), pogo pins and pressure sensitive conductive rubbers (PCRs). The effects of solder bumps and balls can also be taken into account. A short-open-load-reciprocal (SOLR) calibration method is used with a reciprocal thru to instead of the conventional short-open-load-thru (SOLT) which uses a standard thru. The S-parameters can be measured up to 40 GHz with a repeatable S21 parameter accuracy of better than 0.2 dB and 1 degree in magnitude and phase, respectively. Additionally, the eye diagrams are measured at a maximum data rate of 40 Gb/s and a minimum rise time of 10 ps with the help of Agilent physical layer test system (PLTS).
Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements (2018)

Here we present a guide on ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties on mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N, (ii) ion mobility does not measure surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model, (iii) methods relying on calibration are empirical (and thus may provide method-dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort towards establishing primary standards and reference materials for ion mobility, and provides recommendations to do so.
Pseudorabies Virus UL3 Gene Codes for a Nuclear Protein Which Is Dispensable for Viral Replication (2003)

ABSTRACT Many of the products of the ca. 80 genes encoded by alphaherpesviruses have already been identified and, at least tentatively, functionally characterized. Among the least characterized proteins are the products of the genes homologous to herpes simplex virus UL3, which are present only in the subfamily Alphaherpesvirinae . To identify the UL3 protein of the porcine alphaherpesvirus pseudorabies virus (PrV), the complete PrV UL3 open reading frame was cloned, expressed in Escherichia coli as a glutathione S -transferase fusion protein, and used for immunization of a rabbit. In Western blots, the generated antiserum specifically detected a 34-kDa protein in PrV-infected cells, which was absent from purified virus preparations, indicating that PrV UL3 encodes a nonstructural protein. In indirect immunofluorescence analysis, the anti-UL3 serum produced predominantly nuclear staining in transfected as well as in infected cells, which was not altered in the absence of other virus-encoded nuclear proteins such as the UL31 and UL34 gene products. To investigate UL3 function, a deletion mutant, PrV-ΔUL3F2, was constructed and characterized. This mutant replicated and formed plaques on noncomplementing cells indistinguishable from wild-type PrV, demonstrating that PrV UL3 is not required for virus propagation in cultured cells. Moreover, ultrastructural examinations revealed no impairment of capsid formation in the nucleus, nuclear egress of capsids, virion maturation in the cytoplasm, or virus release. Thus, the overall properties of PrV UL3 are similar to those described for the homologous herpes simplex virus proteins which may be indicative of a common, yet hitherto unknown, function in alphaherpesvirus replication. However, based on our studies, an involvement of the UL3 homologs in virion formation appears unlikely.
Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels (2022)

The natural product indole-3-carbinol (I3C) and its major digestive product 3,3'-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer. In this study, we explored the calcium channel activity of DIM, its synthetic derivative 3,3'-Diindolylmethanone (DIM-one) and related I3C and DIM-one analogs. For the first time, DIM, DIM-one and analog IX were identified as selective blockers for T-type Ca<sub>V</sub>3.3 (IC<sub>50</sub>s DIM 2.09 µM; DIM-one 9.07 µM) while compound IX inhibited both Ca<sub>V</sub>3.2 (6.68 µM) and Ca<sub>V</sub>3.3 (IC<sub>50</sub> = 3.05 µM) using a FLIPR cell-based assay to measure inhibition of T-type calcium channel window current. Further characterization of DIM by electrophysiology revealed it inhibited inward Ca<sup>2+</sup> current through Ca<sub>V</sub>3.1 (IC<sub>50</sub> = 8.32 µM) and Ca<sub>V</sub>3.3 (IC<sub>50</sub> = 9.63 µM), while IX partially blocked Ca<sub>V</sub>3.2 and Ca<sub>V</sub>3.3 inward Ca<sup>2+</sup> current. In contrast, DIM-one preferentially blocked Ca<sub>V</sub>3.1 inward Ca<sup>2+</sup> current (IC<sub>50</sub> = 1.53 µM). The anti-proliferative activities of these compounds revealed that oxidation of the methylene group of DIM shifted the selectivity of DIMs from breast cancer cell line MCF-7 to colon cancer cell line HT-29.
A sustainable pathway of cellulosic ethanol production integrating anaerobic digestion with biorefining (2009)

Anaerobic digestion (AD) of animal manure is traditionally classified as a treatment to reduce the environmental impacts of odor, pathogens, and excess nutrients associated with animal manure. This report shows that AD also changes the composition of manure fiber and makes it suitable as a cellulosic feedstock for ethanol production. Anaerobically digested manure fiber (AD fiber) contains less hemicellulose (11%) and more cellulose (32%) than raw manure, and has better enzymatic digestibility than switchgrass. Using the optimal dilute alkaline pretreatment (2% sodium hydroxide, 130 degrees C, and 2 h), enzymatic hydrolysis of 10% (dry basis) pretreated AD fiber produces 51 g/L glucose at a conversion rate of 90%. The ethanol fermentation on the hydrolysate has a 72% ethanol yield. The results indicate that 120 million dry tons of cattle manure available annually in the U.S. can generate 63 million dry tons of AD fiber that can produce more than 1.67 billion gallons of ethanol. Integrating AD with biorefining will make significant contribution to the cellulosic ethanol production.