gebhart/patrepeval huggingface dataset:
Drone Recognition by Micro-Doppler and Kinematic (2021)

Illegal, malicious or dangerous uses of drones, require developing systems capable of detecting, tracking and recognizing them in a non-collaborative way, and with enough anticipation in order to assign adapted interception means to the threat. The reduced size of autonomous aircraft makes it difficult to be detected over long distances with sufficient awareness based on conventional techniques, and seems more suitable for observation by radar sensors. However, the radiofrequency detection of this kind of object poses other difficulties to be solved due to their slow speed characteristics which can cause confusion with other mobile echoes like land vehicles, birds and vegetation movements agitated by atmospheric turbulence. It is therefore necessary to design robust classification methods for these echoes to ensure their discrimination relative to criteria characterizing their movements (micro-movements of their moving parts and kinematic movements of their main body).
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models (2018)

Staphylococcus aureus produces membrane-derived vesicles (MVs), which share functional properties to outer membrane vesicles. Atomic force microscopy revealed that S. aureus-derived MVs are associated with the bacterial surface or released into the surrounding environment depending on bacterial growth conditions. By using a comparative proteomic approach, a total of 131 and 617 proteins were identified in MVs isolated from S. aureus grown in Luria-Bertani and brain-heart infusion broth, respectively. Purified S. aureus MVs derived from the bacteria grown in either media induced comparable levels of cytotoxicity and neutrophil-activation. Administration of exogenous MVs increased the resistance of S. aureus to killing by whole blood or purified human neutrophils ex vivo and increased S. aureus survival in vivo. Finally, immunization of mice with S. aureus-derived MVs induced production of IgM, total IgG, IgG1, IgG2a, and IgG2b resulting in protection against subcutaneous and systemic S. aureus infection. Collectively, our results suggest S. aureus MVs can influence bacterial-host interactions during systemic infections and provide protective immunity in murine models of infection.
Syntheses and Application of Novel Blue Phosphorescent Iridium Complexes to OLEDs (2006)

We synthesized novel iridium complexes having a cyano and/or fluorine-containing phenylpyridine ligands for organic light emitting diodes (OLEDs). The optical properties of these complexes were investigated by ultraviolet-visible (UV-vis) absorption and photoluminescence (PL) spectrophotometer. The emission color ranges from blue to green depending on the position of substituent groups. One of the complexes, bis[(5-cyano-2-fluorophenyl)-pyridinato-N,C2'] (dipivaloylnate) iridium (III), with the substituent groups on 2 and 5 positions, showed a greenish blue emission peak at 476 nm. The OLED with a structure of glass substrate / indium-tin-oxide (ITO) / tetraphenyl-benzidine-containing poly (arylene ether sulfone) (TPDPES) doped with tris (4-bromophenyl) aminium hexachloro-antimonate (TBPAH) / 2,2'-Bis[3''-(N,N'-ditolylamino) phenyl]biphenyl (3DTAPBP) / iridium complex-doped 2,2'-Bis[4''-(N -carbazole)phenyl] biphenyl (4CzPBP) / 3-(4-biphenyl)-4-phenyl-5-(4-tert-butylphenyl)-1,2,4-triazole (t-Bu-TAZ) / lithium fluoride (LiF)/ aluminum (Al) exhibited the external quantum efficiency of 17 % and the power efficiency of 33 lm/W at 100cd/m2.
Nanoporous Membranes of Hydrogen‐bridged Smectic Networks with Nanometer Transverse Pore Dimensions (2008)

Nanoporous membranes are made based on photoreactive hydrogen-bridged smectic liquid crystal dimers. The self-assembled layered structure is locked by photopolymerization. The hydrogen bridges are reversibly opened by heating or by changing the pH. This forms periodic pores of which the integrity is conserved by a covalent crosslinker, setting the spacing at ca. 1 nm. The pores are covered with carboxylic anions that bind to cations or to amines.
Temperature cross-sensitivity characteristics of singlemode–multimode–singlemode fiber structure (2015)

The temperature cross-sensitivity characteristics of a singlemode-multimode-singlemode (SMS) fiber structure packaged by a shell are studied both theoretically and experimentally. By theoretical investigation, we found that the temperature sensitivity of a SMS structure is mainly determined by the thermo-optic effect (TOE) of the cladding of the multimode fiber (MMF). Meanwhile, the TOE of the MMF core, thermal expansion effects (TEEs) of the MMF core, and the packaging material also influence the ultimate sensitivity, and the magnitude of their effects depends on the refractive index of the MMF cladding. Among them, the TEE of the packaging material, inducing an axial strain, is considered to be the second main factor. A temperature sensor based on a packaged SMS structure is designed and investigated to experimentally verify the theoretical findings. The experimentally measured temperature sensitivity of the sensor is -453.4 pm/°C, which agrees well with the theoretical prediction.
Fracking Deep Convolutional Image Descriptors (2014)

In this paper we propose a novel framework for learning local image descriptors in a discriminative manner. For this purpose we explore a siamese architecture of Deep Convolutional Neural Networks (CNN), with a Hinge embedding loss on the L2 distance between descriptors. Since a siamese architecture uses pairs rather than single image patches to train, there exist a large number of positive samples and an exponential number of negative samples. We propose to explore this space with a stochastic sampling of the training set, in combination with an aggressive mining strategy over both the positive and negative samples which we denote as "fracking". We perform a thorough evaluation of the architecture hyper-parameters, and demonstrate large performance gains compared to both standard CNN learning strategies, hand-crafted image descriptors like SIFT, and the state-of-the-art on learned descriptors: up to 2.5x vs SIFT and 1.5x vs the state-of-the-art in terms of the area under the curve (AUC) of the Precision-Recall curve.
Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction (2017)

Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-wk-old rats. SPECT/CT (<sup>125</sup>I) measurement of cardiac iodine uptake allowed calculation of the <sup>131</sup>I doses needed to deliver 10- or 20-Gy cardiac radiation at 10 wk of age. Radiated (Rad; 10 or 20 Gy) and control rats were studied at 30 wk of age. Body weight, blood pressure, and heart rate were similar in control and Rad rats. Compared with control rats, Rad rats had impaired exercise capacity, increased LV diastolic stiffness, impaired LV relaxation, and elevated filling pressures but similar LV volume, EF, end-systolic elastance, preload recruitable stroke work, and peak +dP/d<i>t</i> Pathology revealed reduced microvascular density, mild concentric cardiomyocyte hypertrophy, and increased LV fibrosis in Rad rats compared with control rats. In the Rad myocardium, oxidative stress was increased and in vivo PKG activity was decreased. Experimental cardiac radiation exposure resulted in diastolic dysfunction without reduced EF. These data provide insight into the association between cardiac radiation exposure and HFpEF risk and lend further support for the importance of inflammation-related coronary microvascular compromise in HFpEF.<b>NEW & NOTEWORTHY</b> Cardiac radiation exposure during radiotherapy increases the risk of heart failure with preserved ejection fraction. In a novel rodent model, cardiac radiation exposure resulted in coronary microvascular rarefaction, oxidative stress, impaired PKG signaling, myocardial fibrosis, mild cardiomyocyte hypertrophy, left ventricular diastolic dysfunction, and elevated left ventricular filling pressures despite preserved ejection fraction.
Maturation of Monocyte-Derived DCs Leads to Increased Cellular Stiffness, Higher Membrane Fluidity, and Changed Lipid Composition (2020)

Dendritic cells (DCs) are professional antigen-presenting cells of the immune system. Upon sensing pathogenic material in their environment, DCs start to mature, which includes cellular processes, such as antigen uptake, processing and presentation, as well as upregulation of costimulatory molecules and cytokine secretion. During maturation, DCs detach from peripheral tissues, migrate to the nearest lymph node, and find their way into the correct position in the net of the lymph node microenvironment to meet and interact with the respective T cells. We hypothesize that the maturation of DCs is well prepared and optimized leading to processes that alter various cellular characteristics from mechanics and metabolism to membrane properties. Here, we investigated the mechanical properties of monocyte-derived dendritic cells (moDCs) using real-time deformability cytometry to measure cytoskeletal changes and found that mature moDCs were stiffer compared to immature moDCs. These cellular changes likely play an important role in the processes of cell migration and T cell activation. As lipids constitute the building blocks of the plasma membrane, which, during maturation, need to adapt to the environment for migration and DC-T cell interaction, we performed an unbiased high-throughput lipidomics screening to identify the lipidome of moDCs. These analyses revealed that the overall lipid composition was significantly changed during moDC maturation, even implying an increase of storage lipids and differences of the relative abundance of membrane lipids upon maturation. Further, metadata analyses demonstrated that lipid changes were associated with the serum low-density lipoprotein (LDL) and cholesterol levels in the blood of the donors. Finally, using lipid packing imaging we found that the membrane of mature moDCs revealed a higher fluidity compared to immature moDCs. This comprehensive and quantitative characterization of maturation associated changes in moDCs sets the stage for improving their use in clinical application.
Multiply coated microspheres. A platform for realizing fields-induced structural transition and photonic bandgap (2000)

Abstract Under crossed electric and magnetic fields, multiply coated microspheres form columnar crystallites with an internal structure that transforms from body-centered-tetragonal to face-centered-cubic as the ratio between the magnetic and the electric fields exceeds a minimum value. The observed transition scenario is in excellent agreement with calculations. These multiply coated microspheres also serve as building blocks for photonic crystals. Robust photonic gaps exist in any periodic structure built from such spheres when the filling ratio of the spheres exceeds a threshold.
19th International Workshop in OCL and Textual Modeling (OCL 2019) (2019)

International audience
Raman image-activated cell sorting and beyond (2022)

We present Raman image-activated cell sorting (RIACS), a technology that performs real-time coherent Raman image-based sorting of single live cells with a throughput of up to ~100 cells per second. Specifically, the fast image acquisition of the RIACS is enabled by multicolor stimulated Raman scattering (SRS) imaging based on a pulse-pair-resolved wavelength-switchable laser. To show the broad utility of the RIACS, we show its applicability to diverse cell types and sizes. The technology is highly versatile and holds promise for numerous applications that are previously difficult or undesirable with fluorescence-based technologies.
What Is the Difference between the Manganese Porphyrin and Corrole Analogues of Cytochrome P450's Compound I? (2001)

A fundamental difference is observed in the ground states of the oxo–manganese complexes of corrole (1) and porphyrin (2). Density functional calculations show that whereas [MnOPor]+ complexes, such as 2, have a MnIVO porphyrin radical ground state, the corrole complex 1 prefers a MnVO ground state. Density functional calculations on oxo–manganese complexes of corrole (1) and porphyrin (2 and 3) show a fundamental difference. The ground state of 1 is the singlet manganese(V) state, 1A(MnV), in which corrole is a closed shell. In contrast, 2 and 3 have high-spin manganese(IV) states, 3A1u and 3A2u, respectively. This difference and the state ordering for each system are rationalized based on the competition between the intrinsic tendency of manganese to prefer high-spin electronic configurations, vis-à-vis the general tendency to prefer double occupancy in the low-lying orbitals. The outcome of this competition is determined primarily by the identity of the macrocycle, corrole versus porphyrin. Corrole with a small cavity holds the MnO moiety with a high off-plane displacement, and thereby prefers the low-spin state. On the other hand, porphyrin with the wider cavity holds the MnO moiety closer to the plane, and thereby prefers high-spin states. De fundamentele verschillen tussen oxo-mangaan complexen met corrool (1) en porfyrine (2 en 3) zijn met behulp van dichtheidsfunctionaal berekeningen aangetoond. De grondtoestand van 1 is een singulet mangaan(V) toestand, 1A(MnV), waarin corrool een gesloten schil heeft. Complexen 2 en 3 daarentegen hebben een hoog-spin mangaan(IV) grondtoestand, respectievelijk 3A1u en 3A2u. Dit verschil tesamen met de toestandsvolgorde voor elk systeem is gerationalizeerd op de basis van de competitie tussen de intrinsieke voorkeur van mangaan voor hoog-spin electronische configuraties ten opzichte van de algemene voorkeur voor dubbel-bezetting van de laagliggende orbitalen. Het resultaat van deze competitie wordt voornamelijk bepaald door de identiteit van de macrocyclus, corrool ten opzichte van porfyrine. De MnO eenheid zit in de corrool groep ingesloten doch is sterk uit het vlak getild waardoor de laagspin toestand de voorkeur krijgt. Porfyrine daarentegen heeft de MnO eenheid dichterbij het vlak, wat de voorkeur geeft aan hoogspin toestanden.
Abstract A29: EYA4 is a risk- and survival-associated TSG that is deleted and hypermethylated in the earliest stages of NSCLC (2010)

Abstract Background: Previous familial linkage studies have identified a tumor suppressor locus at 6q23-25 in lung cancer (LC). However, no single gene has yet been implicated within this 30 Mb region. The identification of two-hit targets — genes disrupted by two mechanisms at the DNA level, such as copy number loss and hypermethylation — involved in LC risk and development will lead to better methods for risk assessment, early detection and treatment. Methods: EYA4 was identified as a two-hit target using multidimensional genome-wide analysis combining gene dosage, DNA methylation, and gene expression data in non-small cell lung cancer (NSCLC) and early pre-malignant lesions with matched adjacent non-malignant tissue. The association of allelic variants with LC risk was assessed in data collected by the Genetic Epidemiology of Lung Cancer Consortium (GELCC), and the association of gene expression with prognosis was investigated in public data using statistical analyses. Bronchial epithelial cells of LC patients and high risk individuals were examined for early hypermethylation of EYA4. The role of EYA4 in apoptosis, and the association of EYA4 with the DNA repair genes GADD45a and γ-H2AX was assayed using stable EYA4 mRNA knock-downs in lymphoblast cell lines. Cells were either serum-starved for 12 and 24 hours followed by Annexin5/propidium iodide staining and GADD45a qRT-PCR, or irradiated, and levels of γ-H2AX protein were measured over time. Results: Integration of NSCLC gene dosage, DNA methylation and mRNA expression showed EYA4 to be frequently affected by two-hits and significantly down-regulated. Numerous EYA4 variants were associated with familial LC, and low EYA4 expression was significantly associated with poor prognosis in multiple independent data sets. Congruent with EYA family member function, in vitro assays revealed that EYA4 knock-down cells displayed a decrease in the number of apoptotic cells following serum starvation. Further investigations led to the discovery of EYA4 hypermethylation not only in the bronchial epithelial brushings of NSCLC patients, but also in the brushings of individuals at a high risk of LC development. EYA4 knock-down led to attenuation of the GADD45a DNA damage repair response, as well as increased levels of γ-H2AX following DNA damage repair. Conclusions: EYA4 is a gene disrupted early and frequently that maps to a locus previously associated with cancer risk. It is implicated in somatic as well as familial cancers, and is likely a tumor suppressor gene with apoptotic and DNA repair functions. The direct association of EYA4 with risk and survival as well as its early disruption underscores its relevance on a clinical level. Citation Information: Cancer Prev Res 2010;3(12 Suppl):A29.
Power variations of wireless communication systems (2010)

The use of wireless digital communication devices like GSM, WCDMA, HSPA, DECT, and WiFi changes the exposure of electromagnetic waves toward the user. Concentrating on the power variations on a slow and fast time scale, these new systems are discussed. Experimental results for both uplink and downlink are included for a sample of systems. The spectrum of the power fluctuations is seen as a convenient and compact way of describing very complex system behavior. The results are of interest for scientific studies of epidemiology and biological effects, and for general electromagnetic compatibility (EMC) aspects.
Nucleation and random movement of filaments in the propagation of high-power laser radiation in a turbulent atmosphere (1999)

The nucleation and random movement of a nonlinear moving focus in a turbulent atmosphere during the propagation of a high-power subpicosecond laser pulse was investigated for a medium with fluctuations of the refractive index. It was shown by statistical sampling methods that under turbulent conditions the length corresponding to the establishment of a nonlinear focus in which the intensity reaches the ionisation threshold is on average reduced compared with the similar length in a regular medium. The focus, moving along a random path, outlines in air a 'curved' filament, the random displacement of which may reach several millimetres in the cross-sectional plane.
[A case of glioblastoma manifesting 49 years after lobotomy]. (1998)

We report a case of glioblastoma manifesting 49 years after a lobotomy. He was diagnosed as having schizophrenia at age 20 and was operated on with a standard lobotomy when he was 27 years old. He had led a useful life after 40 years old without medication. Because of hallucination and delusion, he was hospitalized at the end of 1996. CT showed a well enhanced tumor adjacent to the cavity made by the lobotomy in the left frontal lobe. This is the second case report of glioblastoma just beside the cavity formed by lobotomy. The relationship between glioblastoma and old lobotomy is discussed, especially in regard to morphology and CT findings.
People management framework using a 2D camera for human-robot social interactions (2019)

International audience
Synthetic Peptide Design for Functionalized Hydrogels: Development of Cellularly Responsive Drug Delivery Platforms and Cyclic, Multivalent Peptide Derivatives Using Radical-Mediated Thiol-ene/thiol-yne Chemistries (2010)

Poly(ethylene glycol) (PEG)-based hydrogels represent a class of biomaterials with a growing interest for their application in numerous fields, such as drug delivery and regenerative medicine. PEG is commonly used in these applications due to its hydrophilic and bioinert properties. Additionally, peptides have been successfully incorporated within PEG hydrogels to serve as biological functionalities within a synthetic polymer platform. Peptide-functionalized PEG hydrogels have been shown to act as extracellular matrix (ECM)-mimics capable of enhancing cell survival, function, and differentiation. Alternatively, peptides can be designed to degrade in recognition of highly specific, cell-secreted proteases. This phenomenon has been exploited for the fabrication of peptide-functionalized "smart" hydrogels, capable of undergoing macroscopic property changes in response to cellular events. The goal of this thesis work was to design functional peptide sequences and control their presentation within PEG hydrogels for various biological applications.\nSpecifically, two unique therapeutic delivery platforms containing covalently incorporated human neutrophil elastase (HNE) sensitive peptides were designed. First, substrates were engineered with amino acid point mutations ultimately resulting in enzymatically-controlled degradation kinetics of varying rates. These peptides were photopolymerized within PEG hydrogels as pendant functionalities, and their subsequent release was only observed in the presence of enzyme. The rate of release was ultimately dictated by environmental factors (e.g., [enzyme]) and substrate design (e.g., kcat). Next, HNE-sensitive peptides were incorporated as functional crosslinks within PEG-based hydrogels using thiol-ene photopolymerization. Protein therapeutics were included in the pre-cursor solution and physically entrapped upon gel formation. The peptide crosslinks render the gel degradable and allow for protein release upon exposure to HNE. The rate of gel degradation and subsequent protein release was influenced by gel formulation, enzyme concentration, and substrate design.\nFinally, cyclic, multivalent peptides were designed and synthesized using sequential thiol-ene/thiol-yne chemistries, exploiting the versatility of these radical-mediated photoreactions. Results demonstrate that these novel synthetic routes provide a robust and efficient method to form complex peptide architectures that better mimic protein structure. Collectively, this thesis provides insight related to peptide design and subsequent use within synthetic hydrogels for various biological applications, especially those related to drug delivery and regenerative medicine.
Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma (2023)

&lt;p&gt;Table S4 includes immune signature and iCluster results.&lt;/p&gt;
Finite-size effects in amorphous Fe90Zr10/Al75Zr25multilayers (2012)

The thickness dependence of the magnetic properties of amorphous Fe${}_{90}$Zr${}_{10}$ layers is explored using Fe${}_{90}$Zr${}_{10}$/Al${}_{75}$Zr${}_{25}$ multilayers. The Al${}_{75}$Zr${}_{25}$ layer thickness is kept at 40 \AA{}, while the thickness of the Fe${}_{90}$Zr${}_{10}$ layers is varied between 5 and 20 \AA{}. The thickness of the Al${}_{75}$Zr${}_{25}$ layers is sufficiently large to suppress any significant interlayer coupling. Both the Curie temperature and the spontaneous magnetization decrease nonlinearly with decreasing thickness of the Fe${}_{90}$Zr${}_{10}$ layers. No ferromagnetic order is observed in the multilayer with 5-\AA{} Fe${}_{90}$Zr${}_{10}$ layers. The variation of the Curie temperature ${T}_{\mathrm{c}}$ with the Fe${}_{90}$Zr${}_{10}$ layer thickness $t$ is fitted with a finite-size scaling formula $[1\ensuremath{-}{T}_{\mathrm{c}}(t)/{T}_{\mathrm{c}}(\ensuremath{\infty})]={[(t\ensuremath{-}{t}^{\ensuremath{'}})/{t}_{0}]}^{\ensuremath{-}\ensuremath{\lambda}}$, yielding $\ensuremath{\lambda}=1.2$, and a critical thickness ${t}^{\ensuremath{'}}=6.5$ \AA{}, below which the Curie temperature is 0.