gebhart/patrepeval huggingface dataset:
Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions—A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology (2016)

The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogenetic mechanisms and in developing effective therapies that have transformed this syndrome into a chronic disease. Myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. Recently, following new interesting advances in understanding myocardial ROS and RNS signaling pathways, new promising therapeutical approaches with antioxidant properties are being developed, keeping in mind that scavenging ROS and RNS tout court is detrimental as well, since these molecules also play a role in physiological myocardial homeostasis.
Orientational properties and dynamics of nematic liquid crystals mixed with dendrimers for electro-optical switches (2004)

Novel two-phase materials based on nematic liquid crystals (LC E7) filled with poly(propylene imine) dendrimers of 2–3 nm diameter were investigated for application in light-scattering, electro-optical switches. Polarizing optical microscopy, differential scanning calorimetry and rheological experiments all indicate the presence of a pronounced polydomain structure within these LC mixtures. The molecular ordering and dynamics of the dendrimer-filled nematics were studied in more detail by dielectric relaxation spectroscopy. The director order parameter S d was derived from the strength of the two principal molecular relaxations, α and δ, in the presence and absence of an electric field. In addition, a three-phase model was applied for determining the size of the different LC populations in the mixture. A substantial decrease in the fraction of randomly oriented LC was found upon application of a d.c. field. Over a broad temperature range the LC molecular dynamics were assessed from the variation in the strength of the dielectric relaxations as a function of the d.c. bias. A fast response was found at room temperature. Electro-optical switching experiments showed that the dendrimer-filled LCs can be switched rapidly from a light-scattering, opaque state to a more transparent state.
Packetization Layer Path Maximum Transmission Unit Discovery (PLPMTUD) For IPsec Tunnels (2018)

This document describes Packetization Layer PMTU Discovery (PLPMTUD)
procedures for IPSec tunnels. In these procedures, the encrypting node
discovers and maintains a running estimate of the tunnel MTU. In order
to do this, the encrypting nodes sends Probe Packets of various size
through the IPSec tunnel. If the size of Probe Packet exceeds the
tunnel MTU, a downstream node discards the packet and sends an ICMP
PTB message to the encrypting node. The encrypting node ignores the
ICMP PTB message. If the size of the Probe Packet does not exceed the
tunnel MTU and the decrypting node receives the Probe Packet, the
decrypting node sends an Acknowledgement Packet to encrypting node
through the IPSec tunnel. The Acknowledgement Packet indicates the
size of the Probe Packet. The procedures described in this document
are applicable to IPSec tunnels that are signaled by IKEv2 and provide
authentication services.
A New Power MEMS Component with Variable Capacitance (2003)

ABSTRACT Autonomous devices such as wireless sensors and sensor networks need a long battery lifetime in a small volume. Incorporating micro-power-generators based on ambient energy increases the lifetime of these systems while reducing the volume. This paper describes a new approach to the conversion of mechanical energy, available in vibrations, to electrical energy. The conversion principle is based on charge transportation between two parallel capacitors. An electret is used to polarize the device. A large-signal model was developed, allowing simulations of the behavior of the generator. A small-signal model was then derived in order to quantify the output power as a function of the design parameters. These models show the possibility of generating up to 40 μW with a device of 10 mm 2 . A layout was made based on a standard SOI-technology, available in an MPW. With this design a power of 1 μW at 1020 Hz is expected.
A comparison of iron oxides photodeposited in porous Vycor glass and tetramethoxysilane/methanol/water xerogels (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA comparison of iron oxides photodeposited in porous Vycor glass and tetramethoxysilane/methanol/water xerogelsEdgar A. Mendoza, Eugene Wolkow, D. Sunil, Peter Wong, Jonathon Sokolov, Miriam H. Rafailovich, Marten Den Boer, and Harry D. GafneyCite this: Langmuir 1991, 7, 12, 3046–3051Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://doi.org/10.1021/la00060a023RIGHTS & PERMISSIONSArticle Views104Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
All-optically controlled light valve assembled by photorefractive crystal and PDLC hybrid structure (2015)

A light-valve device, assembled by Ru–doped Bi<sub>12</sub>SiO<sub>20</sub> (BSO) photoconductive substrate and polymer dispersed liquid crystal layer is proposed, in which all the processes are controlled by the near infrared light. Laser beam illumination (Gaussian shape) on BSO:Ru crystal caused charge carriers generation, which migrate and form an inhomogeneous distribution and subsequent space charge field. This surface-localized electromagnetic field penetrates into the PDLC layer and modulate the orientation of the liquid crystals, that caused reverse of the device initial opaque state to the highly transparent one. The proposed structure is simple and easy to fabricate, without requirements of ITO contacts and alignment layers and opens further possibilities for near-infrared applications.
Supplementary Methods, Tables 1 - 19, Figures 1 - 5 from Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Supplementary methods, statistical methods, results, tables, and figures. Supplementary Table 1. CRS grading system. Supplementary Table 2. Samples collected and time points on the trials. Supplementary Table 3. HLH diagnostic criteria. Supplementary Table 4. Timing of severe CRS relative to CRS onset and time from infusion. Supplementary Table 5. Patient demographics and baseline characteristics. Supplementary Table 6. Co-morbid infections. Supplementary Table 7. Median (range) for baseline cytokine values comparing normal subjects and total study population, children on the trials, and adults on the trials. Supplementary Table 8. Median (range) baseline cytokine values comparing baseline disease burden. Supplementary Table 9. Median (range) one-month peak cytokine values in children and adults comparing CRS grades (0-3 vs 4-5). Supplementary Table 10. Time points of target cytokine assessment listed as day since CTL019 infusion, with the acceptable windows provided by the study protocols. Supplementary Table 11. Median (range) day 1-3 peak cytokine values for those with severe (grade 4-5) and without severe (grade 0-3) CRS for total study population, and split into adults and children. Supplementary Table 12. Summary of all predictive models generated by discovery cohort and validated. Supplementary Table 13. Clinical details on the validation cohort. Supplementary Table 14. Therapies used for CRS. Supplementary Table 15. Tocilizumab use by grade and age, as well as, clinical effects of tocilizumab on CRS. Supplementary Table 16. Lee CRS grading scale. Supplementary Table 17. Davila CRS grading scale. Supplementary Table 18. Reclassification of CRS severity by dividing grade 3 into 3a and 3b. Supplementary Table 19. Summary of top predictive models with alternate determination of CRS severity. Supplementary Figure 1. CRP and ferritin are poor early predictors of severe CRS. Supplementary Figure 2. Early increases in IFNγ and sgp130 after CTL019 infusion are associated with development of severe CRS. Supplementary Figure 3. Severity of CRS correlates moderately with CAR T cell expansion but early expansion of CAR T cells does not predict CRS severity. Supplementary Figure 4. Cytokine profiles predict CRS. Supplementary Figure 5. Alternate CRS prediction models.&lt;/p&gt;
1-tert-Butyl-2-methylphospholane–borane and its coupling product 2,2′-bis(1-tert-butylphospholane–borane) (2000)

The title compound, C9H22BP, and its coupling product, C16H38B2P2, were synthesized and their crystal structures analyzed by X-ray diffraction. The molecular structures clearly explain the stereoselective reaction pathways leading to the products. The average P—B distance and C—P—B angle are 1.929 Å and 114°, respectively.
Analytical techniques for the characterization of Antibody Drug Conjugates: Challenges and prospects (2017)

Antibody drug conjugates are increasingly being researched for the treatment of cancer. Accurate and reliable characterization of ADCs is inevitable for their development as potential therapeutic agent. Different analytical techniques have been used in order to decipher heterogeneous nature of antibody drug conjugates, enabling successful characterization. This review will summarize specially three major analytical tools i.e. UV-Vis spectroscopy, liquid chromatography, and mass spectrometry used in characterization of antibody drug conjugates. In this review, major challenges during analysis due to the inherent features of analytical techniques and antibody drug conjugates are summarized along with the modifications intended to address each challenge.
Livrable D5.2 of the PERSEE project : 2D/3D Codec architecture (2011)

Livrable D5.2 du projet ANR PERSEE
Microstructured hydrogels to guide self-assembly and function of lung alveolospheres (2021)

Abstract Epithelial cell organoids have increased opportunities to probe questions on tissue development and disease in vitro and for therapeutic cell transplantation. Despite their potential, current protocols to grow these organoids almost exclusively depend on culture within three-dimensional (3D) Matrigel, which limits defined culture conditions, introduces animal components, and results in heterogenous organoids (i.e., shape, size, composition). Here, we describe a method that relies on polymeric hydrogel substrates for the generation and expansion of lung alveolar organoids (alveolospheres). Using synthetic hydrogels with defined chemical and physical properties, human induced pluripotent stem cell (iPSC)-derived alveolar type 2 cells (iAT2s) self-assemble into alveolospheres and propagate in Matrigel-free conditions. By engineering pre-defined microcavities within these hydrogels, the heterogeneity of alveolosphere size and structure was reduced when compared to 3D culture while maintaining alveolar type 2 cell fate of human iAT2 and primary mouse tissue-derived progenitor cells. This hydrogel system is a facile and accessible culture system for the culture of primary and iPSC-derived lung progenitors and the method could be expanded to the culture of other epithelial progenitor and stem cell aggregates.
Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells (2015)

Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline with a 3-pyridinylboronic acid, the coupling of an aryl bromide with an indolylboronic acid and the reaction of a 3-amino-4-bromopyrazole with 4-carbamoylphenylboronic acid. In all of these processes, the Suzuki-Miyaura reaction was fast and relatively efficient using a palladium catalyst under microwave irradiation. The process was incorporated into a rapid 3-step microwave-assisted method for the synthesis of a MK2 inhibitor involving 3-aminopyrazole formation, pyrazole C-4 bromination using N-bromosuccinimide (NBS), and Suzuki-Miyaura cross-coupling of the pyrazolyl bromide with 4-carbamoylphenylboronic acid to give the target 4-arylpyrazole in 35% overall yield, suitable for study in WS cells.
A 3.2 kHz, 14-Bit Optical Absolute Rotary Encoder With a CMOS Profile Sensor (2008)

We have developed a 3.2 kHz, 14-bit optical absolute rotary encoder system using a profile sensor and a slit disc. The profile sensor, which we have designed for this purpose, is a unique CMOS area image sensor aimed at high-speed position detection of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</i> and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Y</i> axes. <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Y</i> axis profile data from the profile sensor is used for recognition of an index code on the slit disc, and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</i> axis profile data is used for position detection of the index code. This combination of two-axis information enables high resolution even with a small number of index codes (64 indexes) and a small amount of digital calculations. Experimental results show that this system can detect rotation with an angular resolution of 14 bits (0.022deg) and a maximum detection speed of 3.2 kHz.
Measurement of differential cross sections for νμ-Ar charged-current interactions with protons and no pions in the final state with the MicroBooNE detector (2020)

We present an analysis of MicroBooNE data with a signature of one muon, no pions, and at least one proton above a momentum threshold of $300\text{ }\text{ }\mathrm{MeV}/\mathrm{c}$ ($\mathrm{CC}0\ensuremath{\pi}Np$). This is the first differential cross-section measurement of this topology in neutrino-argon interactions. We achieve a significantly lower proton momentum threshold than previous carbon and scintillator-based experiments. Using data collected from a total of approximately $1.6\ifmmode\times\else\texttimes\fi{}{10}^{20}$ protons on target, we measure the muon neutrino cross section for the $\mathrm{CC}0\ensuremath{\pi}Np$ interaction channel in argon at MicroBooNE in the Booster Neutrino Beam which has a mean energy of around 800 MeV. We present the results from a data sample with estimated efficiency of 29% and purity of 76% as differential cross sections in five reconstructed variables: the muon momentum and polar angle, the leading proton momentum and polar angle, and the muon-proton opening angle. We include smearing matrices that can be used to ``forward fold'' theoretical predictions for comparison with these data. We compare the measured differential cross sections to a number of recent theory predictions demonstrating largely good agreement with this first-ever dataset on argon.
Fabrication of Diamond Membranes for X-Ray Masks by Hot-Filament Method (1992)

Diamond thin films have been grown on a Si substrate by a hot-filament method with mixtures of CH 4 and H 2 , and properties such as stress and optical transmittance were investigated for free-standing membrane films as a function of methane concentration (0.5-2.0%) and deposition pressure (8-80 Torr). Ellipsometric and Raman scattering measurements were also carried out to evaluate the film structure, and graphite and void components. It has been found that the loss in the optical transparency is mainly due to light scattering at the surface. It is also shown that boron doping is useful for decreasing the film resistivity, which is advantageous for electron beam (EB) writing and inspections.
Crystal structures of trichloro(.eta.5-cyclopentadienyl)titanium(IV) and -zirconium(IV) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structures of trichloro(.eta.5-cyclopentadienyl)titanium(IV) and -zirconium(IV)Lutz M. Engelhardt, Rocco I. Papasergio, Colin L. Raston, and Allan H. WhiteCite this: Organometallics 1984, 3, 1, 18–20Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/om00079a005https://doi.org/10.1021/om00079a005research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Polyclonal B cell activation by B cell differentiation factor B151-TRF2. I. Involvement of self-Ia recognition process mediated by B cells. (1986)

The present study examined the functional role of Ia antigens on B cells in polyclonal B cell activation induced by a B cell differentiation factor, B151-TRF2. The polyclonal IgM PFC responses by B151-TRF2 were inhibited by monoclonal antibodies specific for class II MHC antigens (Ia antigens) but not class I MHC antigens. Such inhibition by anti-Ia antibodies was haplotype-specific and was observed in the absence of both T cells and accessory cells. Moreover, the anti-Ia antibody-induced inhibition of the B151-TRF2 responses was not due to the blocking of binding of B151-TRF2 to the corresponding B cell receptor. A series of kinetic studies revealed that some Ia-mediated cellular activation process occurs before the resting B cells become responsive to B151-TRF2. Thus, the B151-TRF2-mediated B cell responses consist of at least two distinct phases. The early phase is an Ia-dependent but B151-TRF2-independent process, whereas the late phase is an Ia-independent but B151-TRF2-dependent process. To further characterize the functional role of Ia antigens on B cells, an additional experiment was carried out by using F1 B cells which co-dominantly express both parental Ia antigens on the surface. Interestingly, it was observed that the degree of inhibition of the B151-TRF2-mediated responses of F1 B cells by anti-parental Ia antibody was, at best, one-half that of the parental B cells, suggesting that F1 B cells may be separated into two subpopulations with the restriction specificity for the respective parental Ia antigens. To examine this possibility, (B10 X B10.BR)F1 B cells were separated into adherent and nonadherent cell populations by their ability to bind to either one of the parental B cell monolayers, and the specificity of inhibition of their responses to B151-TRF2 by anti-Ia antibodies was assessed. It was found that the responses of (B10 X B10.BR)F1 B cells adherent to the B10 B cell monolayer or the B10.BR B cell monolayer were almost completely inhibited by anti-I-Ab and anti-I-Ak antibodies, whereas those of nonadherent cells were now selectively inhibited by anti-I-Ak and anti-I-Ab antibodies, respectively. These findings are interpreted as indicating that the B151-TRF2-responsive F1 B cells consist of at least two subpopulations with the restriction specificity for either one of the parental Ia antigens.(ABSTRACT TRUNCATED AT 400 WORDS)