gebhart/patrepeval huggingface dataset:
Design of Steel Storage Rack Columns via the Direct Strength Method (2012)

The paper presents an attempt to predict the load carrying capacity of perforated rack columns by the direct strength method (DSM). The investigation is focused on two different issues: the prediction of the elastic buckling loads of members with multiple perforations; and the evaluation of the accuracy of the current DSM buckling curves when applied to rack columns. In relation to the first issue, a model for the calculation of the reduced thickness of the perforated strip to be used in finite-strip buckling analysis is developed. Regarding the study of the DSM curves, it is demonstrated that they can be used to accurately determine the strength of rack cross sections whose failure is governed by distortional buckling or global buckling (with no significant participation of local buckling). This is an interesting result because it will allow substituting the distortional buckling tests, that are currently carried out in the process of design of these columns, by a simple and easy to apply calculation procedure.
Public Logistics Network Protocol Design and Implementation (2007)

A public logistics network (PLN) is proposed as an alternate network to private logistics networks for the ground transport of parcels. In a PLN, a pricing protocol is used to coordinate the operation of the network. The goal of the proposed protocol is to match the load that values transport the highest with the truck that can provide that service at the least cost. This protocol has been implemented using the Microsoft .NET framework. The implementation specifies DC services and the package bidding process. Total logistics cost (TLC) is used to evaluate the performance of the protocol. The protocol is compared to a FIFO protocol under several different scenarios.
WALNUT: A Benchmark on Semi-weakly Supervised Learning for Natural Language Understanding (2022)

Guoqing Zheng, Giannis Karamanolakis, Kai Shu, Ahmed Awadallah. Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2022.
Photowritable Silver‐Containing Phosphate Glass Ribbon Fibers (2015)

Tailored silver‐containing zinc‐phosphate glasses possess excellent thermoviscous ability and optical properties. Beyond they have proven to form a favorable matrix for the direct laser writing of photoluminescent and nonlinear patterns. Here, bringing together the merits of these materials with fiber optic technology, the first photosensitive, photowritable silver‐containing glass ribbon fibers are reported. These novel devices are thermally scaled‐down in a homothetic fashion from a macroscopic preform to produce tens‐of‐meters of continuous structure. It is demonstrated that luminescence properties of the native glass are preserved after the shaping process. Furthermore it is established that the unique fiber's flat geometry allows for the convenient, accurate laser writing of complex luminescent silver clusters patterns within the glass matrix. It is believed that the drawing of silver‐containing zinc‐phosphate glasses could lead to a decisive breakthrough in the field of photosensitive fibers. They would offer a promising platform for the design of highly efficient sensing devices based on amplified optical processes effects, for metamaterials or as fundamental bricks for photonics.
A Case of Compressive Optic Neuropathy Secondary to Lymphoma of the Extraocular Muscles (2019)

Compressive optic neuropathy is an urgent condition that may lead to blindness. We report a rare case of compressive optic neuropathy secondary to lymphoma of the extraocular muscles in which the vision was successfully rescued. A 67-year-old man presented with visual acuity of hand motion in the right eye for 1 month. Magnetic resonance imaging demonstrated enlargement of the medial and inferior rectus muscles with their tendons. Tendon enlargement, which is uncommon as Graves' orbitopathy, motivated us to perform a biopsy. Intravenous steroids following biopsy and chemotherapy after definitive diagnosis allowed for recovery of vision. Clinicians should be aware that enlarged extraocular muscles due to lymphoma can cause compressive optic neuropathy.
Supplementary Figure 4 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance (2023)

&lt;p&gt;PDF file - 109K, EMT signature predicts resistance to EGFR and PI3K inhibitors and greater sensitivity to Axl inhibition&lt;/p&gt;
ChemInform Abstract: Kinetics of Dialkylaminium Cation Radical Reactions: Radical Clocks, Solvent Effects, Acidity Constants, and Rate Constants for Reactions with Hydrogen Atom Donors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Applying Microseismicity to Hydraulic Fracture Monitoring as a Tool to Improve the Understanding and Development of Tight Gas Reservoirs (2006)

Real time microseismic monitoring of the growth of the hydraulic fractures in treatment wells, implemented in StimMAP system, allows high accuracy direct measurement of frac system geometry (height, length and azimuth) during fracturing as well as obtaining of useful information concerning formation geophysical and geological properties, optimization and planning of further fracturing in the same region. This presentation gives brief review and comparison of existed methods of fracturing monitoring, explains basics of microseismic monitoring and shows case study applications of the method.
ChemInform Abstract: An Efficient Aerobic Oxidative Cyanation of Tertiary Amines with Sodium Cyanide Using Vanadium Based Systems as Catalysts. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microscopic understanding of the low resistance state retention in HfO<inf>2</inf> and HfAlO based RRAM (2014)

We study in detail the impact of alloying HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> with Al (Hf <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1−x</inf> Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2x</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+x</inf> ) on the device characteristics through materials characterization, electrical measurements and atomistic simulation. Indeed, movements of individual oxygen atoms inside the dielectric are at the heart of RRAM operations. Therefore, we performed diffusion barrier calculations relative to the oxygen vacancy (VO) movement involved in R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> data retention. Calculations are performed at the best level using ab initio techniques. Our study provides an insight on the improved R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> stability of Hf <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1−x</inf> Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2x</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+x</inf> RRAM, via a simple explanation based on its higher atomic density (atoms/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) associated with shorter bond lengths between cations and anions in the presence of Al.
Abstract 10075: Hematopoietic Mosaic Chromosomal Alterations and Cardiovascular Disease-Related Deaths Among Cancer Survivors: An Analysis of the UK Biobank (2022)

Introduction: Cancer survivors are at an increased risk for cardiovascular (CV)-related deaths. Recently, clonal hematopoiesis (CH) was described as a novel risk factor for both cancer and CV disease. However, the influence of CH on CV outcomes in cancer survivors has not been explored. Hypothesis: We hypothesized that CH captured by mosaic chromosomal alterations (mCA) could predict the risk of CV outcomes and death following cancer diagnosis. Methods: In the UK Biobank, we identified patients with a history of selected cancer types known for their high CV risk. mCAs were detected using DNA genotyping array intensity data. The association of mCA with CV-death, coronary artery disease (CAD)-death, and any cause death was performed using Cox proportional hazards regression, adjusting for age, sex, smoking, chemotherapy, radiotherapy, and ancestry. Exploratory analyses also included incident CV phenotypes. The specificity of the effect was assessed using a model with an interaction term between mCA and cancer history. Results: Among 48 919 unrelated individuals with a cancer diagnosis, 10 070 patients (20.6%) carried ≥1 mCA clone. Of those, 2432 were autosomal carriers and 1910 had a mCA in ≥10% of peripheral leukocytes. mCA prevalence increased with age: from 4.8% among those aged &lt;49 years old to 30.4% for those aged ≥70 years old. mCA was associated with an increased risk of CAD-death (HR 1.37, 95% CI 1.09-1.71, P= 0.006) and overall mortality (HR 1.07, 95% CI 1.02-1.11, P =0.006). In exploratory analyses, mCA was associated with higher risks of incident STEMI (HR 1.18, 95% CI 1.02-1.37, P =0.022) and peripheral vascular disease (HR 1.17, 95% CI 1.04-1.31, P =0.007). The effect of mCA was specific to cancer survivors for any cause of death ( P interaction &lt;0.001) but not for CAD-death ( P interaction =0.96). Conclusions: Our findings indicate that among cancer survivors, CH captured by mCA was associated with a higher risk of CAD death and overall mortality. Cancer survivors with CH may benefit from targeted CV screening and preventive measures to better manage individual CV risk.
Farm Level Control of Foreign Animal Disease and Food‐Borne Pathogens (2008)

Abstract Preventing the introduction of diseases, especially foreign animal diseases (FADs), and diseases that could cause food‐borne illness is critically important. Science‐based rules and regulations established by the United States Department of Agriculture (USDA) govern activities that could present homeland security risks. This article presents an overview of animal agriculture production in the United States and how that influences farm‐level control of pathogens, preventing and controlling the introduction of FADs by understanding the structure of food‐producing industries and the farm‐level vulnerabilities, and finally, farm‐level control of contemporary critical pathogens. The beef, poultry, and pork‐producing industries are discussed. The beef industry with its extensive nature of production in cow–calf operations is the most vulnerable to agroterrorism. The poultry industry is arguably the industry most protected from an agroterrorist attack. But the poultry and swine industries are still vulnerable, because the structure of these industries and the intensive production practices used has resulted in large numbers of animals located in relatively small geographic areas. So if an FAD outbreak does occur, the potential economic impacts are still very high. Contemporary FADs discussed in detail are highly pathogenic avian influenza (HPAI) foot‐and‐mouth disease (FMD), and classical swine fever (CSF).
NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion (2017)

Nuclear factor erythyroid factor 2 (Nrf2) transcribes genes in cultured endothelial cells that reduce reactive oxygen species (ROS) and generate nitric oxide (NO) or metabolize asymmetric dimethylarginine (ADMA), which inhibits NO synthase (NOS). Therefore, we undertook a functional study to test the hypothesis that activation of Nrf2 by tert-butylhydroquinone (tBHQ) preserves microvascular endothelial function during oxidative stress. Wild-type CB57BL/6 (wt), Nrf2 wt (+/+), or knockout (-/-) mice received vehicle (Veh) or tBHQ (0.1%; activator of Nrf2) during 14-day infusions of ANG II (to induce oxidative stress) or sham. MAP was recorded by telemetry. Mesenteric resistance arterioles were studied on isometric myographs and vascular NO and ROS by fluorescence microscopy. ANG II increased the mean arterial pressure (112 ± 5 vs. 145 ± 5 mmHg; P < 0.01) and excretion of 8-isoprostane F<sub>2α</sub> (2.8 ± 0.3 vs. 3.8 ± 0.3 ng/mg creatinine; P < 0.05) at 12-14 days. However, 12 days of ANG II reduced endothelium-derived relaxation (27 ± 5 vs. 17 ± 3%; P < 0.01) and NO (0.38 ± 0.07 vs. 0.18 ± 0.03 units; P < 0.01) but increased microvascular remodeling, endothelium-derived contractions (7.5 ± 0.5 vs. 13.0 ± 1.7%; P < 0.01), superoxide (0.09 ± 0.03 vs. 0.29 ± 0.08 units; P < 0.05), and contractions to U-46,619 (87 ± 6 vs. 118 ± 3%; P < 0.05), and endothelin-1(89 ± 4 vs. 123 ± 12%; P < 0.05). tBHQ prevented all of these effects of ANG II at 12-14 days in Nrf2<sup>+/+</sup> mice but not in Nrf2<sup>-/-</sup> mice. In conclusion, tBHQ activates Nrf2 to prevent microvascular endothelial dysfunction, remodeling, and contractility, and moderate ADMA and hypertension at 12-14 days of ANG II infusion, thereby preserving endothelial function and preventing hypertension.
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice (2016)

In conclusion, our study demonstrates that the cholesterol regulator LXR acts as a positive regulator of eosinophilic asthma in mice, contributing to airway inflammation through regulation of type 2 cytokine production.
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques (2021)

ABSTRACT To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines capable of eliciting neutralizing antibody responses against multiple CoVs. Because of the phylogenetic similarity to humans, rhesus macaques are an animal model of choice for many virus-challenge and vaccine-evaluation studies, including SARS-CoV-2. Here, we show that immunization of macaques with SARS-CoV-2 spike (S) protein generates potent receptor binding domain cross- neutralizing antibody (nAb) responses to both SARS-CoV-2 and SARS-CoV-1, in contrast to human infection or vaccination where responses are typically SARS-CoV-2-specific. Furthermore, the macaque nAbs are equally effective against SARS-CoV-2 variants of concern. Structural studies show that different immunodominant sites are targeted by the two primate species. Human antibodies generally target epitopes strongly overlapping the ACE2 receptor binding site (RBS), whereas the macaque antibodies recognize a relatively conserved region proximal to the RBS that represents another potential pan-SARS-related virus site rarely targeted by human antibodies. B cell repertoire differences between the two primates appear to significantly influence the vaccine response and suggest care in the use of rhesus macaques in evaluation of vaccines to SARS-related viruses intended for human use. ONE SENTENCE SUMMARY Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS- related viruses can be readily induced in rhesus macaques because of distinct properties of the naïve macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
CEA and CEA-like activity in gastric cancer. (1976)

CEA activity was studied using a three-layer bridge immunoperoxidase method in paraffin-embedded histological sections of gastric mucosa from patients with gastric cancer and from normal asymptomatic subjects. In all cases gastric cancer cells showed CEA or CEA-like activity irrespective of the histological type of cancer. The activity was located mainly in cellular membranes, on the brush border or in apical parts of the cell cytoplasm. CEA activity could not be demonstrated in mucosa specimens from normal controls. These results indicate that the appearance of CEA or CEA-like substances is regularly associated with the malignant transformation of epithelial cells of the gastric mucosa.
Comparison of the transient performance of STATCOM and Synchronous condenser at HVDC converter stations (2015)

This paper compared the transient performance of Synchronous Condenser and Static Compensator (STATCOM) at HVDC systems. The impacts of the two reactive power compensators to the connected HVDC system during various aspects of transients, including fault recovery, temporary over voltage and commutation failure, are investigated based on Electromagnetic Transients (EMT) Simulation. The study results demonstrated that STATCOMs and SCs have the similar performance during those transients.
Low-Temperature Catalytic NO Reduction with CO by Subnanometric Pt Clusters (2019)

The catalytic subnanometric metal clusters with a few atoms can be regarded as an intermediate state between single atoms and metal nanoparticles (>1 nm). Their molecule-like electronic structures and flexible geometric structures bring rich chemistry and also a different catalytic behavior, in comparison with the single-atom or nanoparticulate counterparts. In this work, by combination of operando IR spectroscopy techniques and electronic structure calculations, we will show a comparative study on Pt catalysts for CO + NO reaction at a very low temperature range (140-200 K). It has been found that single Pt atoms immobilized on MCM-22 zeolite are not stable under reaction conditions and agglomerate into Pt nanoclusters and particles, which are the working active sites for CO + NO reaction. In the case of the catalyst containing Pt nanoparticles (∼2 nm), the oxidation of CO to CO<sub>2</sub> occurs in a much lower extension, and Pt nanoparticles become poisoned under reaction conditions because of a strong interaction with CO and NO. Therefore, only subnanometric Pt clusters allow NO dissociation at a low temperature and CO oxidation to occur well on the surface, while CO interaction is weak enough to avoid catalyst poisoning, resulting in a good balance to achieve enhanced catalytic performance.
Strut Position, Blood Flow, and Drug Deposition (2005)

Simulations that coupled strut configurations with flow dynamics correlated with in vivo effects and revealed that drug deposition occurs less via contact between drug coating and the arterial wall than via flow-mediated deposition of blood-solubilized drug.
Activation of Matrix Metalloproteinase-9 via Neuronal Nitric Oxide Synthase Contributes to NMDA-Induced Retinal Ganglion Cell Death (2005)

These findings suggest that an extracellular proteolytic pathway in the retina contributes to RGC death via NO-activated MMP-9.
Direct-conversion quadrature modulator MMIC design with a new 90/spl deg/ phase shifter including package and PCB effects for W-CDMA applications (2006)

This paper presents a wideband code-division multiple-access direct-conversion quadrature modulator monolithic-microwave integrated-circuit (MMIC) design that employs a new technique to generate the 90/spl deg/ phase shift with low implementation loss. From the bare-chip measurement, this new 90/spl deg/ phase shifter has been proven with an amplitude and phase error less than 0.6 dB and 0.8/spl deg/, respectively, within the applied frequency range from 1.85 to 1.98 GHz. The package and printed circuit board (PCB) interconnects are also analyzed using the three-dimensional electromagnetic simulation tool and transformed into the equivalent-circuit elements for co-simulation with the designed quadrature modulator MMIC. The degradation of error vector magnitude and sideband suppression due to the package and PCB can be well predicted and verified by measurements. Although the proposed 90/spl deg/ phase shifter has a remarkable advantage over the others in implementation loss, it is quite susceptible to the package and PCB effects and needs more design efforts to deal with those effects.
Supplementary Figure S4 from Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine (2023)

&lt;p&gt;A. Gating strategy applied for flow cytometry analysis of NK cell panel. Phenotype of NK cell (CD56dim CD16+ ) activation was quantified using expression of cell surface markers CD69, CD107a, CD45RA, and CD45RO based on the indicated gates. B. NK cell frequency before and after the treatment analyzed in PBMCs from 18 patient samples and grouped according long-and short-survivors. C. Frequency of NK cells expressing cell surface activation markers CD69, CD107a, and CD45RA and CD45RO measured in short-and long-survival groups before and after the treatment.&lt;/p&gt;
Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies (2015)

Monitoring of minimal residual disease (MRD) has become routine clinical practice in frontline treatment of virtually all childhood acute lymphoblastic leukemia (ALL) and in many adult ALL patients. MRD diagnostics has proven to be the strongest prognostic factor, allowing for risk group assignment into different treatment arms, ranging from significant treatment reduction to mild or strong intensification. Also in relapsed ALL patients and patients undergoing stem cell transplantation, MRD diagnostics is guiding treatment decisions. This is also why the efficacy of innovative drugs, such as antibodies and small molecules, are currently being evaluated with MRD diagnostics within clinical trials. In fact, MRD measurements might well be used as a surrogate end point, thereby significantly shortening the follow-up. The MRD techniques need to be sensitive (≤10(-4)), broadly applicable, accurate, reliable, fast, and affordable. Thus far, flow cytometry and polymerase chain reaction (PCR) analysis of rearranged immunoglobulin and T-cell receptor genes (allele-specific oligonucleotide [ASO]-PCR) are claimed to meet these criteria, but classical flow cytometry does not reach a solid 10(-4), whereas classical ASO-PCR is time-consuming and labor intensive. Therefore, 2 high-throughput technologies are being explored, ie, high-throughput sequencing and next-generation (multidimensional) flow cytometry, both evaluating millions of sequences or cells, respectively. Each of them has specific advantages and disadvantages.
ChemInform Abstract: Pyrimidines. Part 67. Synthesis and Antihuman Immunodeficiency Virus ( HIV‐1) Activity of 3′‐Deoxy‐3′‐(triazol‐1‐yl)thymidines and 2′,3′‐ Dideoxy‐3′‐(triazol‐1‐yl)uridines, and Inhibition of Reverse Transcriptase by Their 5′‐Triphosphates. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.