gebhart/patrepeval huggingface dataset:
Spatial resolution for two-beam spectroscopy: a new mechanism (1981)

With the help of interference effects, two-beam and multiple-beam spectroscopy detect in the pairs of beams (bundles of rays selected by the optical system) phase correlations due to certain fluctuations in optically thin distributions of incoherent light sources. Originally spatial resolution along the line of sight was expected for multiple-beam spectroscopy because of the limited region of intersection for pairs of beams. Here more general analysis shows another mechanism of spatial resolution allowing use of broader overlapping beams. Thus a simpler two-beam spectroscopy configuration (to be discussed in more detail elsewhere) capable of making more efficient use of emitted light proves to offer the same localized measurement of spatially harmonic fluctuations in the appropriate light source distributions.
Gaussian integration technique to predict backscatter characteristics from ultrasound contrast agents (2005)

Many new ultrasound imaging modalities, such as second harmonic, subharmonic and ultraharmonic detection techniques, that take advantage of the nonlinear characteristics of contrast microbubbles have emerged recently. Control and prediction of the occurrence and amplitude of the nonlinear emissions from ultrasound contrast microbubbles are important for the further development of these techniques. A Gaussian-integration (GI) method for predicting the nonlinear emission signals from microbubbles with wide size distribution is presented. The GI method is validated preliminarily by the nonlinear emissions from Levovist/spl reg/ and ST68/spl reg/ contrast microbubbles, with good results. This method may provide a computationally inexpensive means of examining the backscatter spectrum from multiple bubbles, and could be used as an inverse method in predicting bubble characteristics from backscatter spectra.
A literatura de cordel de Manoel Monteiro (2014)

This study deals with the cordel literature written by Manoel Monteiro, which has been published repeatedly since 1952 and with increasing regularity during the past six years. Manoel Monteiro seeks to contribute to the aesthetic and sociocultural education of sections of the Brazilian population that are less fortunate, both financially and culturally. Therefore, his poetry, consistently conscious of its status as an art and as a technique, is in large part a poetry of protest, of ideals, and of faith in human potential.
3D stacked microfluidic cooling for high-performance 3D ICs (2012)

Cooling is a significant challenge for high-performance high-power 3D ICs. hi this paper, we describe the experimental evaluation of 3D ICs with embedded microfluidic cooling. Different architectures are experimentally evaluated ine hiding: 1) a memory-on-processor stack. 2) a processor-on-processor stack with equal power dissipation, and 3) a processor-on-processor stack with different power dissipation, hi all cases, embedded microfluidic cooling shows significant junction temperature reduction compared to air-cooling.
An object-oriented approach to data management: why design databases need it (1987)

An object-oriented approach to management of engineering design data requires object persistence, object-specific rules for concurrency control and recovery, views, complex objects and derived data, and specialized treatment of operations, constraints, relationships and type descriptions. We discuss object-orientation as more than an implementation paradigm, and show how an object-oriented approach simplifies both use and implementation of engineering design systems.
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications (2018)

12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has shown that 12-LOX plays a critical role in the modulation of inflammation at multiple checkpoints during diabetes development. Due to this, interventions to limit pro-inflammatory 12-LOX metabolites either by isoform-specific 12-LOX inhibition, or by providing specific fatty acid substrates via dietary intervention, has the potential to significantly and positively impact health outcomes of patients living with both type 1 and type 2 diabetes. To date, the development of truly specific and efficacious inhibitors has been hampered by homology of LOX family members; however, improvements in high throughput screening have improved the inhibitor landscape. Here, we describe the function and role of human 12-LOX, and mouse 12-LOX and 12/15-LOX, in the development of diabetes and diabetes-related complications, and describe promise in the development of strategies to limit pro-inflammatory metabolites, primarily via new small molecule 12-LOX inhibitors.
Characterization of the Subunit Structure of the Catalytically Active Type I Iodothyronine Deiodinase (2001)

Type I iodothyronine deiodinase is a approximately 50-kDa, integral membrane protein that catalyzes the outer ring deiodination of thyroxine. Despite the identification and cloning of a 27-kDa selenoprotein with the catalytic properties of the type I enzyme, the composition and the physical nature of the active deiodinase are unknown. In this report, we use a molecular approach to determine holoenzyme composition, the role of the membrane anchor on enzyme assembly, and the contribution of individual 27-kDa subunits to catalysis. Overexpression of an immunologically unique rat 27-kDa protein in LLC-PK1 cells that contain abundant catalytically active 27-kDa selenoprotein decreased deiodination by approximately 50%, and > 95% of the LLC-PK1 derived 27-kDa selenoprotein was specifically immune precipitated by the anti-rat enzyme antibody. The hybrid enzyme had a molecular mass of 54 kDa and an s(20,w) of approximately 3.5 S indicating that every native 27-kDa selenoprotein partnered with an inert rat 27-kDa subunit in a homodimer. Enzyme assembly did not depend on the presence of the N-terminal membrane anchor of the 27-kDa subunit. Direct visualization of the deiodinase dimer showed that the holoenzyme was sorted to the basolateral plasma membrane of the renal epithelial cell.
DESIGN CONSIDERATION OF LARGE-DISPLACEMENT RF MEMS TUNERS UNDER FABRICATION UNCERTAINTIES (2015)

DESIGN CONSIDERATION OF LARGE-DISPLACEMENT RF MEMS TUNERS UNDER FABRICATION UNCERTAINTIES - 1st International Conference on Uncertainty Quantification in Computational Sciences and Engineering - 25 - 27 May 2015 Crete Island, Greece
Abstract 5112: Immune biomarkers of clinical response after NSAID treatment in combination with vaccination targeting EGFR-COX2-CDC25B in the APC(Min/+) mouse model (2023)

Abstract Studies from our group have shown that administration of NSAIDs in mouse models of Familial Adenomatous Polyposis (FAP) results in a decrease in the development in small intestinal polyps with a significant increase in CD8 tumor infiltrating lymphocytes (TIL) and downregulation of PD-L1 on tumors. Furthermore, we have demonstrated that NSAIDs could be used in combination with vaccination to even further reduce the development of intestinal polyps. We questioned what tissue specific biomarkers could define the efficacy of response with the combination treatment. APC(Min/+) male and female mice (4-6 weeks old) were immunized with a multi-antigen (EGFR, COX2, CDC25B) peptide vaccine with CFA/IFA as an adjuvant. Control mice received immune adjuvant alone. Regular chow or chow containing 400 ppm naproxen was provided intermittently (3 weeks on, 3 weeks off for 3 cycles) or continuously (18 weeks on) at the initiation of the vaccine regimen. Animals were euthanized at 22 weeks and tumors quantified. TIL were evaluated by flow cytometry. Since intermittent naproxen treatment was just as effective at inhibiting tumor development as continuous naproxen treatment, with or without vaccine, we did not differentiate between NSAID regimens. We observed an increase in CD8+ (83%; p&amp;lt;0.0001), Tbet+CD4+ (94%; p&amp;lt;0.001), effector memory (EM) CD4+ (76%; p&amp;lt;0.0001) and EM CD8+ (94%; p&amp;lt;0.0001) TIL in the tumors that did develop in the mice treated with the combination NSAID and vaccination as compared to control. There was increased CD8+ (Pearson correlation coefficient: −0.506, p&amp;lt;0001), Tbet+CD4+ (Pearson correlation coefficient: -0.6222, p&amp;lt;0.001), EM CD4+ (Pearson correlation coefficient: 0.-6074, p&amp;lt;0.001) and EM CD8+ (Pearson correlation coefficient: -0.7155, p&amp;lt;0.001) in mice with greater tumor inhibition than those with less protection. Receiver operator curves revealed that CD8+ (AUC: 0.7623; p=0.002), Tbet+CD4+ (AUC 0.7273; p=0.008), EM CD4+ (AUC 0.6782; p=0.04) and EM CD8 (AUC 0.7897; p&amp;lt;0.001) TIL can differentiate mice receiving the combination of NSAID and vaccination as compared to either monotherapy alone. These data define potential biomarkers of response that can guide human clinical trials of NSAIDs +/- vaccination in patients with FAP. Citation Format: Denise L. Cecil, Ying Liu, Lauren Corulli, Mary L. Disis. Immune biomarkers of clinical response after NSAID treatment in combination with vaccination targeting EGFR-COX2-CDC25B in the APC(Min/+) mouse model. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5112.
Synthesis, crystal structure and solution fluxionality of heterometallic hydride clusters [WRu3L(CO)11(µ-H)2-(AuPPh3)](L = C5H5or C5Me5) (1993)

Two heterometallic compounds [WRu3L(CO)11(µ-H)2(AuPPh3)](L = C5H51 or C5Me52) were prepared by hydrogenation of [WRu3L(CO)12(AuPPh3)] in refluxing tetrahydrofuran solution. The C5H5 derivative possesses a tetrahedral Ru3W core in which the AuPPh3 unit bridges a Ru–Ru edge, one hydride caps a nearby WRu2 face and the second spans a Ru–Ru edge, whereas the corresponding C5Me5 derivative adopts a related but distinct molecular geometry in the solid state, in which both hydride ligands span the equivalent Ru–W edges and the AuPPh3 unit is linked to the Ru atoms supporting the hydrides. The dynamic processes in solution were established for these two derivatives. Crystal data for 1: monoclinic, space group P21/c; a= 9.031(2), b= 25.086(4), c= 16.238(3)Å, β= 95.75(2)°, Z= 4; final R= 0.036, R′= 0.032 for 4391 reflections with l > 2σ(l). Crystal data for 2: space group Pna21; a= 20.389(3), b= 16.226(3), c= 26.074(4)Å, Z= 8; final R= 0.040, R′= 0.036 for 4556 reflections with l > 2σ(I).
Adoptive T-cell therapy for malignant disorders (2008)

Adoptive cell transfer (ACT) using ex vivo manipulated T lymphocytes has emerged as an important advance in cancer immunotherapy, allowing for re-education and re-setting of the host immune system. Recent technological advances, particularly the development of artificial antigen presenting cells (
Immunological options for the treatment of tuberculosis: evaluation of novel therapeutic approaches (2007)

The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.
Secure authentication on the Internet of Things (2017)

This paper describes biometric-based cryptographic techniques for providing confidential communications and strong, mutual and multifactor authentication on the Internet of Things. The described security techniques support the goals of universal access when users are allowed to select from multiple choice alternatives to authenticate their identities. By using a Biometric Authenticated Key Exchange (BAKE) protocol, user credentials are protected against phishing and Man-in-the-Middle attacks. Forward secrecy is achieved using a Diffie-Hellman key establishment scheme with fresh random values each time the BAKE protocol is operated. Confidentiality is achieved using lightweight cryptographic algorithms that are well suited for implementation in resource constrained environments, those limited by processing speed, limited memory and power availability. Lightweight cryptography can offer strong confidentiality solutions that are practical to implement in Internet of Things systems, where efficient execution, and small memory requirements and code size are required.
An efficient hardware-based fault diagnosis scheme for AES: performances and cost (2004)

Since standardization in 2001, the Advanced Encryption Standard has been the subject of many research efforts, aimed at developing effcient hardware implementations with reduced area and latency. So far, reliability has not been considered a primary objective. Recently, several error detecting schemes have been proposed in order to provide some defense against hardware faults in AES. The benefits of such schemes are twofold: avoiding wrong outputs when benign hardware faults occur, and preventing the collection of information about the secret key through malicious injection of faults. In this paper, we present a complete scheme for parity-based fault detection in a hardware implementation of the Advanced Encryption Standard which includes a key schedule unit. We also provide a preliminary evaluation of the hardware and latency overhead of the proposed scheme.
PASSION Runtime Library for parallel I/O (2002)

We are developing a compiler and runtime support system called PASSION: Parallel and Scalable Software for Input-Output. PASSION provides software support for I/O intensive out-of-core loosely synchronous problems. This paper gives an overview of the PASSION Runtime Library and describes two of the optimizations incorporated in it, namely data prefetching and data sieving. Performance improvements provided by these optimizations on the Intel Touchstone Delta are discussed together with an out-of-core median filtering application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Experimental Demonstration of Policy-based Dynamic End-to-End Provisioning over Multi-Layer Network using SDN (2016)

Contemporary transport networks require dynamic multi-layer service provisioning to support ever-growing application traffic. We present a software platform architecture based on SDN principles combined with a network policy engine to experimentally demonstrate dynamic multi-layer provisioning over a national dark-fibre network.
Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys (1996)

With the development of chimeric simian-human immunodeficiency virus (SHIV)-infected macaques as a model for assessing novel human immunodeficiency virus type I (HIV-1) envelope glycoprotein (Env)-based vaccine strategies for preventing HIV-1 infection in man, it will be important to determine HIV-1 Env-specific cytotoxic T-lymphocyte (CTL) responses in vaccinated and virus-infected monkeys. To facilitate performing such CTL studies, we have defined two HIV-1 Env CTL epitopes in SHIV-infected rhesus monkeys and characterized the major histocompatibility complex (MHC) class I alleles that bind these Env peptide fragments and present them to CTL. A 9-amino-acid (aa) fragment of HIV-1 gp4l (p6B, aa 553 to 561) is presented to CD8+ CTLs of SHIV-infected animals by the rhesus monkey HLA-B homolog molecule Mamu-B*12. An 8-aa HIV-1 gpl.20 peptide (p9CD, aa 117 to 124) represents a CTL epitope in rhesus monkeys restricted by the HLA-A homolog MHC allele Mamu-A*08. This gp120 CTL epitope is fully conserved in all simian immunodeficiency virus, HIV-1, and HIV-2 isolates that have been sequenced to date and exhibits functional cross-reactivity. Screening of 14 unselected rhesus monkeys for expression of the two novel MHC class I alleles revealed the presence of each of the alleles in more than 40% of the animals. The characterization of the two HIV-1 Env CTL epitopes and their restricting MHC class I alleles will provide a basis for studying vaccine- and virus-elicited cytotoxic effector cell responses in rhesus monkeys.
Hyperfine Constants and Tensor Polarizabilities of4f66s6p9G0–6States in Sm I (1999)

Hyperfine structures, isotope shifts and Stark effects of seven near-infrared transitions in Sm I are investigated by means of atomic-beam laser spectroscopy with fluorescence detection. E 1 transitions from the ground-term 7 F 1–6 states of the 4 f 6 6 s 2 configuration to 9 G 0–6 states of the 4 f 6 6 s 6 p configuration are measured. The 9 G 1,2,3 states are promising candidates for measuring the parity nonconserving effects in Sm. Hyperfine constants A and B for odd-mass isotopes of 147 Sm and 149 Sm are newly determined for the six upper states studied. Isotope shifts of the transitions are determined, and specific mass shift and field shift are also obtained by King-plot analysis. Stark splittings are resolved for three transitions and tensor polarizabilities of the upper states are determined.
Abstract 2048: Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids (2023)

Abstract Genomic analysis of targeted patient tumor sequencing identified frequent mutations, 41% in prostate cancer (Li, et al., 2020) in the gene FOXA1, a developmentally important pioneer transcription factor (TF) in mammary and prostate tissues. Previous work by our group and others has shown that these FOXA1 mutations alter global chromatin accessibility and promote growth in prostate cells (Adams, 2019), but the underlying molecular details, including the identity of partner TFs, remain unclear. To address this topic, we generated mouse prostate organoids expressing Foxa1 alleles harboring three distinct classes of mutations: (i) overexpression of WT Foxa1 (reflecting focal gene amplification seen in tumors), (ii) a series of mutants within the Wing2region of the forkhead binding domain (FHBD) and (iii) a mutant bearing a stop codon after the FHBD to represent a series of C-terminal truncation mutants. We performed single nucleus multiome sequencing to obtain gene expression (snRNA-seq) and chromatin accessibility (snATAC-seq) readouts from the same individual nuclei. Whereas each Foxa1 mutant has distinct, often mutant-specific features, several themes emerge. These include alterations in the relative proportion of stem-like (L2) luminal cells vs secretory (L1) luminal cells as well as changes in luminal or basal gene signatures, increased androgen receptor signaling output, and enrichment for motifs of distinct classes of partner TFs. For example, cells expressing the truncation mutant show gain in the accessibility of Gata3 and Pou2f1 TF binding motifs, as well as enhanced numbers of L1-like luminal cells. Functional studies demonstrate that Pou2f1 is specifically required for the pro-luminal phenotype in cells expressing the truncation mutant whereas Gata3 plays a more general pro-luminal role. Correlations in motif accessibility and transcription factor expression across single cells further revealed a composite androgen receptor (AR)-FOXA1 motif enriched in the pro-luminal truncation mutant, while the canonical AR motif was enriched in pro-basal cell mutants. Finally, Foxa1 mutants cooperative with Trp53 and Pten loss in orthotopic prostate tumorigenicity assays, most strikingly manifest by reversion of the basal-like features characteristic of Trp53/Pten loss tumors to Ck8+ luminal adenocarcinoma histology, mirroring that seen in Foxa1-mutant human prostate cancer tumors in mice. Thus, mutant Foxa1 alleles cooperate with canonical prostate cancer tumor suppressors and alter the histologic phenotype of prostate cancers in mice through the activation of basal or luminal lineage differentiation programs. Citation Format: Erik Ladewig, Abbas Nazir, Christina Leslie, Charles Sawyers. Mutations in FOXA1 alter chromatin remodeling and cell fate in prostate organoids [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2048.
Integrated Photonic Encoder for Terapixel Image Processing (2023)

Modern lens designs are capable of resolving &gt;10 gigapixels, while advances in camera frame-rate and hyperspectral imaging have made Terapixel/s data acquisition a real possibility. The main bottlenecks preventing such high data-rate systems are power consumption and data storage. In this work, we show that analog photonic encoders could address this challenge, enabling high-speed image compression using orders-of-magnitude lower power than digital electronics. Our approach relies on a silicon-photonics front-end to compress raw image data, foregoing energy-intensive image conditioning and reducing data storage requirements. The compression scheme uses a passive disordered photonic structure to perform kernel-type random projections of the raw image data with minimal power consumption and low latency. A back-end neural network can then reconstruct the original images with structural similarity exceeding 90%. This scheme has the potential to process Terapixel/s data streams using less than 100 fJ/pixel, providing a path to ultra-high-resolution data and image acquisition systems.
Ethylene and 1-Hexene Sorption in LLDPE under Typical Gas Phase Reactor Conditions:  A Priori Simulation and Modeling for Prediction of Experimental Observations (2004)

A detailed study has been conducted of the sorption of ethylene and 1-hexene in linear low density polyethylene (LLDPE) under typical gas phase LLDPE reactor conditions. The recently proposed osmotic ensemble hyperparallel tempering method is used to simulate ethylene and 1-hexene gas sorption in the polymer samples. Simulations are used to parametrize the PC−SAFT equation of state for calculation of gas sorption in amorphous polyethylene. A model for crystallite induced elastic constraints is adopted to modify the equation of state for description of gas sorption in polyethylene below melting point conditions. Single-component ethylene and 1-hexene gas sorption as well as ethylene/1-hexene gas co-sorption are studied in this work. It is observed that simulations provide an effective method to parametrize the PC−SAFT equation of state. In addition, since simulations and PC−SAFT assume a hypothetically amorphous polymer, a quantitative description of elastic effects for gas sorption in semicrystalline polyethylene emerges from our approach. The results are verified by comparison to the experimental results of Novak et al. [Novak et al. Manuscript in preparation, 2004].