gebhart/patrepeval huggingface dataset:
Calculation of light distribution in optical devices by a global solution of an inhomogeneous scalar wave equation (1997)

A numerical scheme is suggested for solving the scalar wave equation for optical devices characterized by a z-dependent refractive index. The homogeneous wave equation is converted into a single-column inhomogeneous linear system by applying imaginary (absorbing) boundary potentials at the device boundaries. The imposed absorbing boundary conditions enable discrete representation of the device on a compact grid. Our scheme is based on applying an efficient sparse preconditioner to the linear system, which enables its global solution (i.e., simultaneously for all z values) by fast iterative methods, such as the quasi-minimal residual algorithm. A single solution of the inhomogeneous equation with the imaginary boundary operators allows the calculation of mode-specific as well as region-specific light-intensity coupling probabilities for initial mode of interest. Numerical examples illustrate the usefulness of the suggested scheme to the optimization of optical devices.
Substance P-induced pulmonary vasoreactivity in isolated perfused guinea pig lung. (1988)

We examined the effects of the neuropeptide substance P on pulmonary hemodynamic and transvascular fluid filtration in isolated Ringer's-perfused and blood-enriched Ringer's-perfused guinea pig lung and on albumin flux across bovine pulmonary artery endothelial monolayer. Mean pulmonary artery, left atrial, and capillary pressures were determined and used to calculate arterial and venous resistances, and lung weight was continuously monitored. Substance P (0.01-1.0 microM) caused marked increases in pulmonary arterial pressure, capillary pressure, venous resistance, and lung weight within 3-5 minutes after administration. These responses remained elevated above baseline at the end of the 30-minute experimental period in the Ringer's-perfused lungs but not in the blood-enriched Ringer's-perfused lungs. Substance P did not alter the capillary filtration coefficient in isolated lungs and transendothelial albumin permeability in the endothelial monolayer. Substance P resulted in an increase in venous effluent thromboxane B2 concentrations in perfused lungs but had no effect on 6-keto-prostaglandin F1 alpha concentrations. Papaverine (0.27 mM) (a smooth-muscle relaxant) abolished the pulmonary microvascular response to substance P in Ringer's-perfused lungs, and meclofenamate (0.15 mM) (a cyclooxygenase inhibitor) attenuated the pulmonary vasoconstriction and lung weight increase. Pyrilamine (1.0 microM) (a histamine1-receptor antagonist) did not alter the responses to substance P. In conclusion, substance P does not affect pulmonary vascular permeability to water and protein. Substance P induces an intense pulmonary vasoconstriction (due to greater constriction of postcapillary vessels) and an elevation in pulmonary capillary pressure that increases net transvascular fluid filtration.(ABSTRACT TRUNCATED AT 250 WORDS)
Design for the Mechanical Properties of Polypropylene Discontinuous Fiber-Reinforced Composites Manufactured by Extrusion Molding (2001)

Ovarian cancer stem cells (OCSCs) are in a transitional phase between epithelial and mesenchymal cell stages. Consequently, OCSCs possess a high degree of plasticity that complicates their identification and characterization. However, we recently demonstrated that the combined assessment of key antigens associated with cancer stem cells and the epithelial-mesenchymal transition can distinguish the phenotype of OCSCs from more differentiated cells. In this chapter we describe in detail an appropriate sample preparation for the analysis of epithelial, mesenchymal, and cancer stem cell markers by flow cytometry and immunohistochemistry in ovarian cancer. Furthermore, we provide methods for the establishment of primary ovarian cancer cultures from solid tumors.
Probabilistic Models of Verbal and Body Gestures (1998)

This chapter describes several probabilistic techniques for representing, recognizing, and generating spatiotemporal configuration sequences. We first describe how such techniques can be used to visually track and recognize lip movements in order to augment a speech recognition system. We then demonstrate additional techniques that can be used to animate video footage of talking faces and synchronize it to different sentences of an audio track. Finally we outline alternative low-level representations that are needed to apply these techniques to articulated body gestures.
How can the aromatic side‐chains modulate the conductance of the gramicidin channel? A new approach using non‐coded amino acids (1991)

In order to elucidate the role of the aromatic side-chains in the mechanism of transduction of monovalent cations through the channel of linear gramicidin, two series of analogues containing non-coded aromatic amino acids were synthesized. In the first series, the four tryptophans were replaced by either four L-3-(8-quinolyl)alanyl or four L-3-(4-quinolyl)alanyl residues and single channel conductance measurements showed that these substitutions led to a strong lowering of the channel conductance, which is attributed to a modification of the orientation of the aromatic side-chains due to an increase of their hydrophobicity. In the second series, the analogues contained both tryptophyl and naphthylalanyl residues in various amounts and positions. The single channel conductance data indicated that the conductance was mainly governed by the number of polar residues (Trp) and not by their positions. The conformational consequences of these results are discussed together with their influence on the energy profile of the gramicidin channel.
Multiple Attractor Bifurcations: A Source of Unpredictability in Piecewise Smooth Systems (1999)

There exists a variety of physically interesting situations described by continuous maps that are nondifferentiable on some surface in phase space. Such systems exhibit novel types of bifurcations in which multiple coexisting attractors can be created simultaneously. The striking feature of these bifurcations is that in the presence of arbitrarily small noise they lead to fundamentally unpredictable behavior of orbits as a system parameter is varied slowly through its bifurcation value. This unpredictability gradually disappears as the speed of variation of the system parameter through the bifurcation is reduced to zero.
Bhabha, the post/colonial and Glenn Patterson'sburning your own (1999)

(1999). Bhabha, the post/colonial and Glenn Patterson's burning your own. Irish Studies Review: Vol. 7, No. 1, pp. 65-71.
SPLADE: Sparse Lexical and Expansion Model for First Stage Ranking (2021)

In neural Information Retrieval, ongoing research is directed towards improving the first retriever in ranking pipelines. Learning dense embeddings to conduct retrieval using efficient approximate nearest neighbors methods has proven to work well. Meanwhile, there has been a growing interest in learning sparse representations for documents and queries, that could inherit from the desirable properties of bag-of-words models such as the exact matching of terms and the efficiency of inverted indexes. In this work, we present a new first-stage ranker based on explicit sparsity regularization and a log-saturation effect on term weights, leading to highly sparse representations and competitive results with respect to state-of-the-art dense and sparse methods. Our approach is simple, trained end-to-end in a single stage. We also explore the trade-off between effectiveness and efficiency, by controlling the contribution of the sparsity regularization.
Switching pulse pattern optimisation for modular multilevel converters (2014)

Modular multilevel converters (MMCs) are widely used in different applications such as high voltage direct current (HVDC) applications. The HVDC station loss is highly related to the converter switching pulse pattern which is generated by modulation algorithm and cell selection methods. This paper formulates the switching pulse pattern generation, as a versatile optimisation problem. The problem constraints and objectives are formulated for HVDC applications and compared with similar problems in the field of computer science. To overcome the computational complexity in solving the introduced optimisation problem, a heuristic method is proposed for cell selection algorithm. The method utilizes the current level in order to obtain lossless switching at zero-current crossings. The study of the proposed method, in a time-domain simulation platform, shows that the method can reduce the switching converter losses by 60% compared to carrier-based modulation, maintaining the same capacitor voltage ripple. Although this paper focuses on HVDC, the mathematical model is applicable for any MMC application.
Vapor Transport Thermodynamics of GaP-Cl2-H2 System in an Open Tube (1967)

In order to define the most suitable conditions for the transport of gallium-phosphide the composition of the gas phase is calculated for various temperatures and chlorine-to-hydrogen mole ratios in an open tube process. A transport rate equation base on thermodynamic considerations has been developed. It is shown that the principal components are HCl, GaCl 3 , GaCl, and P 4 at low temperature, and HCl, GaCl, and P 2 at high temperature, in addition to H 2 for a Cl 2 /H 2 mole ratio of 1×10 -2 . The hypothetical partial pressure of gallium-phosphide, from which the deposition rate of GaP may be conveniently estimated, is calculated.
P4‐148: CLINICOPATHOLOGICAL CORRELATION OF A CASE OF DEMENTIA AFTER TBI (2014)

It has long been recognized that moderate or severe TBI occurring in early and mid-life is associated with an increased risk of late life dementia (relative risk 2.5 to 5.0 times normal). However, careful epidemiologic and pathologic studies of dementias occurring after remote TBI have not been performed. Recent case reports and case series have reported unique dementia phenotypes and neuropathology, especially among athletes reporting multiple early and mid-life mild TBIs. We report a case of dementia after recovery from mid-life moderate-to-severe TBI. We reviewed the acute TBI clinical course and recovery trajectory of the patient, and the evaluation and course of a subsequent dementia. His brain was harvested and neuropathological examination included sections from 17 regions stained with hematoxylin and eosin, modified Bielchowski, and immunohistochemically against beta-amyloid and abnormally phosphorylated tau. RB-001 was a 46 year old senior military officer who suffered a TBI during a motor vehicle collision. His Glasgow Coma Score was 12. He was hospitalized 12 days (3 in the ICU) and had 18 days of post-traumatic amnesia. He made a gratifying recovery but complained of persistent dysnomia, irritability and memory problems. He returned to active duty 22 months after injury and was employed until age 59 when he began a cognitive decline. He experienced a rapidly progressive neurocognitive disorder characterized by behavioral/affective symptoms, cognitive dysfunction, and atypical spells with preserved motor function. His MRI found global volume loss with few hyperintense signals in white matter. He died severely demented at age 71, 25 years after his TBI. His brain was atrophic with a remote left frontal contusion and thin posterior corpus callosum. Microscopic examination showed neurofibrillary tangles (NFTs) and senile plaques in the hippocampus and neocortex, and NFTs in the insular/prefrontal cortex and mammillary bodies.Neocortical NFTs did not show sulcal depth or perivascular predominance. His clinical course and neuropathologic findings are atypical and may represent Alzheimer's disease plus components of post-TBI neurodegeneration. This case supports the association between TBI and dementia and highlights the need for complete neuropathological evaluation to identify unique clinicopathologic phenotypes that occur after remote TBI.
Retinoic acid deficiency contributes to the inflammatory status of alcoholic cirrhotic patients (2012)

info:eu-repo/semantics/published
Highly insulating thermoplastic nanocomposites based on a polyolefin ternary blend for high-voltage direct current power cables (2022)

Octyl-silane-coated Al<sub>2</sub>O<sub>3</sub> nanoparticles are found to be a promising conductivity-reducing additive for thermoplastic ternary blends comprising low-density polyethylene (LDPE), isotactic polypropylene and a styrenic copolymer. The ternary blend nanocomposites were prepared by compounding the blend components together with an LDPE-based masterbatch that contained the nanoparticles. The nanoparticles did not affect the superior stiffness of the ternary blends, compared to neat LDPE, between the melting temperatures of the two polyolefins. As a result, ternary blend nanocomposites comprising 38 wt% polypropylene displayed a storage modulus of more than 10 MPa up to at least 150 °C, independent of the chosen processing conditions. Moreover, the ternary blend nanocomposites featured a low direct-current electrical conductivity of about 3 × 10<sup>-15</sup> S m<sup>-1</sup> at 70 °C and an electric field of 30 kV mm<sup>-1</sup>, which could only be achieved through the presence of both polypropylene and Al<sub>2</sub>O<sub>3</sub> nanoparticles. This synergistic conductivity-reducing effect may facilitate the design of more resistive thermoplastic insulation materials for high-voltage direct current (HVDC) power cables.
ChemInform Abstract: Fullerenes with Metals Inside. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tunable Complex-Weight All-Optical IIR Filter Design based on Conversion/Dispersion Delays (2012)

We propose and study the design of a tunable optical infinite-impulse-response filter based on conversion/dispersion delays. Design guidelines are presented to alleviate the effects of the inherent system propagation delay.
Abstract QS43: Blepharophimosis Ptosis Epicanthus Inversus Syndrome Caused by a ZC3H13 Gene Mutation (2018)

PURPOSE: Blepharophimosis Ptosis Epicanthus Inversus Syndrome (BPES) is a rare craniofacial autosomal dominant disorder characterized by severe bilateral ptosis, telecanthus, epicanthus inverses, belpharophimosis and orbital dysmorphology. BPES type 1 is accompanied by ovarian failure and attendant infertility, while type 2 manifests only eyelid and orbital involvement. While BPES is often associated with a dominantly inherited mutation in the forkhead transcription factor FOXL2 (3q23), we sought to capitalize on next generation whole exome sequencing to decipher the cause of BPES in a pedigree lacking a FOXL2 mutation. METHODS: A male patient with BPES was identified at the Yale-New Haven Hospital. Following informed consent, clinical data and blood samples from both affected and unaffected family members were obtained. Genomic DNA was extracted from whole blood samples and subjected to exome capture followed by next generation sequencing. Sequence reads were mapped to the human reference genome. Variants with minor allele frequencies in reference databases were selected and annotated for impact on the encoded protein and for conservation of the reference base and amino acid residue among orthologs across phylogeny. Sanger sequencing was employed to verify candidate mutations. In addition, all FOXL2 exons were subjected to Sanger sequencing to verify sequence status. RESULTS: A four-generation BPES pedigree was identified demonstrating autosomal dominant inheritance. In affected individuals, next generation whole exome sequencing identified a common non-sense mutation in ZC3H13 (13q14.13), which was confirmed by Sanger sequencing. A cytosine to thymine (C>T) alteration resulted in the conversion of arginine 1513 to a premature stop codon (R1513X). The variant 13:46538114 C / T was not found in dbSNP with an ExAC allele frequency of 1.651e-05. The amino acid residue arginine 1513 is evolutionarily conserved from Neurospora crassa (red bread mold) to Homo sapiens. All FOXL2 exons lacked disease-causing alterations. Conclusions: ZC3H13 is a putative tumor suppressor gene encoding a zinc finger CCCH-type containing protein. It localizes to nuclear speckles and is predicted to play a role in mRNA splicing and cell cycle progression. Our data suggest that ZC3H13 mutations represent an additional dominant subtype of BPES and point to a novel role for ZC3H13 in craniofacial development and disease pathogenesis. D.M. Balkin: None. C. Nelson-Williams: None. B.J. Sumpio: None. D.A. Scott: None. P. Le Pabic: None. T.F. Schilling: None. R.P. Lifton: None. D. Narayan: None.
Design and InP HEMT Technology for ultra-high speed digital ICs with beyond 80-Gbit/s operation (2005)

There is great interest in increasing the operating speed of digital circuits. Using 0.10-/spl mu/m gate-length InP HEMT technology, to date we have developed a 144-Gbit/s multiplexer (MUX), a 80-Gbit/s demultiplexer (DEMUX), a 80-Gbit/s D-type flip-flop (D-FF), and a 90-GHz T-type flip-flop (T-FF). Key aspects of the fabrication, circuit design, and measurement are described in this paper.
Monolithic Silicon Photonic Crystal Fiber Tip Sensor for Refractive Index and Temperature Sensing (2010)

We demonstrate that monolithic 2-dimensional silicon photonic crystals confined to the facet of single-mode optical fibers are capable of determining refractive index and temperature of a sample simultaneously from reflectivity measured at two different wavelengths.
Efatutazone, an Oral PPAR-γ Agonist, in Combination With Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial (2013)

Efatutazone and paclitaxel in combination were safe and tolerated and had biologic activity.
Disparity-Aware Stereo 3D Production Tools (2011)

Stereoscopic 3D (S3D) has reached wide levels of adoption in consumer and professional markets. However, production of high quality S3D content is still a difficult and expensive art. Various S3D production tools and systems have been released recently to assist high quality content creation. This paper presents a number of such algorithms, tools and systems developed at Disney Research Zurich, which all make use of disparity-aware processing.
Improving postural stability via computational modeling approach to deep brain stimulation programming (2011)

Bilateral subthalamic (STN) deep brain stimulation (DBS) is generally effective in improving the cardinal motor signs of advanced Parkinson's disease (PD). However, in many cases postural instability is refractory to STN DBS. The goal of this project was to determine if postural instability could be improved with STN DBS by avoiding current spread to the non-motor territories of the STN. Stimulation parameters that maximized activation of a theoretically defined target region were determined via patient-specific computer models created in Cicerone. Postural stability was assessed under three conditions: Off DBS, Clinical DBS, and Model DBS. Clinical settings were the patients' DBS settings determined via traditional clinical practice and were considered optimized and stable for at least 6 months prior to study enrollment. Blinded and randomized evaluations were performed in five patients. Postural sway was significantly less during Model DBS compared to Clinical DBS. These results support the hypothesis that minimizing spread of current to non-motor territories of the STN can improve PD related instability with DBS.
GlobeDB (2005)

We present GlobeDB, a system for hosting Web applications that performs autonomic replication of application data. GlobeDB offers data-intensive Web applications the benefits of low access latencies and reduced update traffic. The major distinction in our system compared to existing edge computing infrastructures is that the process of distribution and replication of application data is handled by the system automatically with very little manual administration. We show that significant performance gains can be obtained this way. Performance evaluations with the TPC-W benchmark over an emulated wide-area network show that GlobeDB reduces latencies by a factor of 4 compared to non-replicated systems and reduces update traffic by a factor of 6 compared to fully replicated systems.
Supplementary Figure 2 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus (2023)

&lt;p&gt;Mechanisms of TSC2 loss in HCC cell lines and xenografts. (A) Taqman RT-PCR analysis of TSC1 and TSC2 mRNA levels in HCC cell lines. (B) Taqman RT-PCR analysis of MZB1, TSC1 and TSC2 mRNA levels in TSC2-null Li-7 cells treated with epigenetic inhibitors. (C) Taqman RT-PCR analysis and (D) immunoblot analysis of TSC2 G305V mutant in HEK293T cells.&lt;/p&gt;
A central domain of Rhizobium NodE protein mediates host specificity by determining the hydrophobicity of fatty acyl moieties of nodulation factors (1995)

Previously, we have shown that the nodE gene is a major determinant of the difference in host range between Rhizobium leguminosarum biovars viciae and trifolii. A new genetic test system for stringent functional analysis of nodE genes was constructed. By testing chimeric nodE genes constructed by the exchange of polymerase chain reaction (PCR)-generated restriction cassettes, we show that a central domain, containing only 44 non-conserved amino acid residues, determines the host specificity of the NodE protein (401 amino acid residues). Mass spectrometric analysis of the lipo-chitin oligosaccharides (LCOs) produced by the new test strain containing the biovar viciae nodE gene shows that molecules containing a polyunsaturated C18:4 (trans-2, trans-4, trans-6, cis-11-octadecatetraenoic) fatty acyl moiety are produced, as is the case for wild-type R. leguminosarum bv. viciae. The LCOs determined by the biovar trifolii nodE gene, which was overproduced in our test strain, carry C18:2 and C18:3 fatty acyl chains containing two or three conjugated trans double bonds, respectively. Therefore, the main difference between the nodE-determined LCOs of biovar viciae and trifolii in this system is the presence or absence of one cis double bond, resulting in the very different hydrophobicity of the LCOs. Using a newly developed spot application assay, we show that the C18:2- and C18:3-containing LCOs are able to induce the formation of nodule primordia on roots of Trifolium pratense. On the basis of these and other recent results, we propose that the host range of nodulation of the R. leguminosarum biovars viciae and trifolii is determined by the degree of hydrophobicity of the polyunsaturated fatty acyl moieties of their LCOs, which is mediated by the host-specific central domain of the NodE protein.
Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage (2012)

Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to dermal vaccination and contact hypersensitivity (CHS) challenge in K14-VEGFR-3-Ig mice, which lack dermal lymphatic capillaries and experience markedly depressed transport of solutes and dendritic cells from the skin to draining LNs. In response to dermal immunization, K14-VEGFR-3-Ig mice produced lower Ab titers. In contrast, although delayed, T cell responses were robust after 21 d, including high levels of Ag-specific CD8+ T cells and production of IFN-γ, IL-4, and IL-10 upon restimulation. T cell-mediated CHS responses were strong in K14-VEGFR-3-Ig mice, but importantly, their ability to induce CHS tolerance in the skin was impaired. In addition, 1-y-old mice displayed multiple signs of autoimmunity. These data suggest that lymphatic drainage plays more important roles in regulating humoral immunity and peripheral tolerance than in effector T cell immunity.