gebhart/patrepeval huggingface dataset:
Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System (2016)

Purpose To assess the feasibility of a magnetically assisted remote-controlled (MARC) catheter system under magnetic resonance (MR) imaging guidance for performing a simple endovascular procedure (ie, renal artery embolization) in vivo and to compare with x-ray guidance to determine the value of MR imaging guidance and the specific areas where the MARC system can be improved. Materials and Methods In concordance with the Institutional Animal Care and Use Committee protocol, in vivo renal artery navigation and embolization were tested in three farm pigs (mean weight 43 kg ± 2 [standard deviation]) under real-time MR imaging at 1.5 T. The MARC catheter device was constructed by using an intramural copper-braided catheter connected to a laser-lithographed saddle coil at the distal tip. Interventionalists controlled an in-room cart that delivered electrical current to deflect the catheter in the MR imager. Contralateral kidneys were similarly embolized under x-ray guidance by using standard clinical catheters and guidewires. Changes in renal artery flow and perfusion were measured before and after embolization by using velocity-encoded and perfusion MR imaging. Catheter navigation times, renal parenchymal perfusion, and renal artery flow rates were measured for MR-guided and x-ray-guided embolization procedures and are presented as means ± standard deviation in this pilot study. Results Embolization was successful in all six kidneys under both x-ray and MR imaging guidance. Mean catheterization time with MR guidance was 93 seconds ± 56, compared with 60 seconds ± 22 for x-ray guidance. Mean changes in perfusion rates were 4.9 au/sec ± 0.8 versus 4.6 au/sec ± 0.6, and mean changes in renal flow rate were 2.1 mL/min/g ± 0.2 versus 1.9 mL/min/g ± 0.2 with MR imaging and x-ray guidance, respectively. Conclusion The MARC catheter system is feasible for renal artery catheterization and embolization under real-time MR imaging in vivo, and quantitative physiologic measures under MR imaging guidance were similar to those measured under x-ray guidance, suggesting that the MARC catheter system could be used for endovascular procedures with interventional MR imaging. (©) RSNA, 2016.
Conversion Dynode (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer (2020)

Ipafricept can be administered with nab-paclitaxel + gemcitabine with reasonable tolerance. Wnt pathway remains a therapeutic target of interest in mPDAC.
DeepSense: Fast Wideband Spectrum Sensing Through Real-Time In-the-Loop Deep Learning (2021)

Spectrum sharing will be a key technology to tackle spectrum scarcity in the sub-6 GHz bands. To fairly access the shared bandwidth, wireless users will necessarily need to quickly sense large portions of spectrum and opportunistically access unutilized bands. The key unaddressed challenges of spectrum sensing are that (i) it has to be performed with extremely low latency over large bandwidths to detect tiny spectrum holes and to guarantee strict real-time digital signal processing (DSP) constraints; (ii) its underlying algorithms need to be extremely accurate, and flexible enough to work with different wireless bands and protocols to find application in real-world settings. To the best of our knowledge, the literature lacks spectrum sensing techniques able to accomplish both requirements. In this paper, we propose DeepSense, a software/hardware framework for real-time wideband spectrum sensing that relies on real-time deep learning tightly integrated into the transceiver's baseband processing logic to detect and exploit unutilized spectrum bands. DeepSense uses a convolutional neural network (CNN) implemented in the wireless platform's hardware fabric to analyze a small portion of the unprocessed baseband waveform to automatically extract the maximum amount of information with the least amount of I/Q samples. We extensively validate the accuracy, latency and generality performance of DeepSense with (i) a 400 GB dataset containing hundreds of thousands of WiFi transmissions collected "in the wild" with different Signal-to-Noise-Ratio (SNR) conditions and over different days; (ii) a dataset of transmissions collected using our own software-defined radio testbed; and (iii) a synthetic dataset of LTE transmissions under controlled SNR conditions. We also measure the real-time latency of the CNNs trained on the three datasets with an FPGA implementation, and compare our approach with a fixed energy threshold mechanism. Results show that our learning-based approach can deliver a precision and recall of 98% and 97% respectively and a latency as low as 0.61ms. For reproducibility and benchmarking purposes, we pledge to share the code and the datasets used in this paper to the community.
Dipole controlled metal gate with hybrid low resistivity cladding for gate-last CMOS with low Vt (2010)

In this contribution, NMOS and PMOS band edge effective work function (EWF) and correspondingly low Vt are demonstrated using standard fab materials and processes in a gate-last scheme. For NMOS, the use of an Al cladding layer results in Vt = 0.08 V consistent with NMOS EWF = 4.15 eV. Migration of the Al cladding into the TiN and a relatively low oxygen concentration near the TiN/HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> interface are responsible for the low EWF. For PMOS, employing a W cladding layer along with a post-TiN anneal in an oxidizing ambient results in elevated oxygen concentration near the TiN/HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> interface and Vt = −0.20 V consistent with a PMOS EWF =5.05 eV. First-principles calculations indicate N atoms displaced from the TiN during the oxidizing anneal form dipoles at the TiN/HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> interface that play a critical role in determining the PMOS EWF.
Wafer level hermetic package and device testing of a SOI-MEMS switch for biomedical applications (2006)

We have designed a wafer level chip scale package for a bi-stable SOI-MEMS dc switch using a silicon-glass hermetic seal with through the lid feedthroughs.Bonded at 365 C, 230 V and 250 kg, they pass the fine/gross leak test after thermal cycling and mechanical shock/vibration according to MIL-STD-833, fulfilling the requirements for biomedical applications.The measured shear strength is 114 26 N in correspondence with the theoretically expected 100 N. Ruthenium microcontacts are a factor of 100 more robust than gold microcontacts, being stable over 10 6 cycles measured in a N 2 atmosphere inside the package presented here.Future work will include a more extensive bond quality assessment and continued microcontact reliability measurements.
[Personal experience with treatment of recurrent herpes infections using combined nonspecific immunostimulation]. (1992)

Using combined non-specific immunostimulation by means of a dialyzed leucocyte extract and bacterial vaccine, the authors treated 11 patients with relapsing herpetic infections. They achieved disappearance or marked improvement of clinical manifestations of the disease in the course of 12 months' treatment. The favourable clinical effect was associated with improvement of parameters of cellular immunity. Treatment was well tolerated by the patients. The only adverse factor was pain at the site of administration of the dialyzed leucocyte extract which persisted for 30 to 180 minutes, but due to the very favourable effect of treatment, was evaluated as insignificant by the patients.
Designing light responsive bistable arches for rapid, remotely triggered actuation (2014)

Light responsive azobenzene functionalized polymer networks enjoy several advantages as actuator candidates including the ability to be remotely triggered and the capacity for highly tunable control via light intensity, polarization, wavelength and material alignments. One signi cant challenge hindering these materials from being employed in applications is their often relatively slow actuation rates and low power densities, especially in the absence of photo-thermal e ects. One well known strategy employed in nature for increasing actuation rate and power output is the storage and quick release of elastic energy (e.g., the Venus ytrap). Using nature as inspiration we have conducted a series of experiments and developed an equilibrium mechanics model for investigating remotely triggered snap-through of bistable light responsive arches made from glassy azobenzene functionalized polymers. After brie y discussing experimental observations we consider in detail a geometrically exact, planar rod model of photomechanical snap-through. Theoretical energy release characteristics and unique strain eld pro les provide insight toward design strategies for improved actuator performance. The bistable light responsive arches presented here are potentially a powerful option for remotely triggered, rapid motion from apparently passive structures in applications such as binary optical switches and positioners, surfaces with morphing topologies, and impulse locomotion in micro or millimeter scale robotics.
Cationic Polybenzoxazines. A Novel Polyelectrolyte Class with Adjustable Solubility and Unique Hydrogen-Bonding Capabilities (2011)

This article fuses the world of benzoxazine chemistry with the field of polyelectrolyte chemistry and introduces a new approach toward water-soluble polybenzoxazines. The synthesis of a novel class of polybenzoxazine-based polyelectrolytes carrying cationic charges in the side chain and/or the backbone is described. Tertiary nitrogen atoms of the backbone or side chain have been methylated in a polymer analogous reaction leading to cationic polybenzoxazines with structure dependent, adjustable solubility in various solvents including water providing unique hydrogen-bonding capabilities. The polymers have been investigated by 13C NMR, SEC, TGA, and DSC.
Higher-order Masking and Shuffling for Software Implementations of Block Ciphers. (2009)

Differential Power Analysis (DPA) is a powerful side channel key recovery attack that efficiently breaks block ciphers implementations. In software, two main techniques are usually applied to thwart them: masking and operations shuffling. To benefit from the advantages of the two techniques, recent works have proposed to combine them. However, the schemes which have been designed until now only provide limited resistance levels and some advanced DPA attacks have turned out to break them. In this paper, we investigate the combination of masking and shuffling. We moreover extend the approach with the use of higher-order masking and we show that it enables to significantly improve the security level of such a scheme. We first conduct a theoretical analysis in which the efficiency of advanced DPA attacks targeting masking and shuffling is quantified. Based on this analysis, we design a generic scheme combining higher-order masking and shuffling. This scheme is scalable and its security parameters can be chosen according to any desired resistance level. As an illustration, we apply it to protect a software implementation of AES for which we give several security/efficiency trade-offs.
Photoredox-induced polymerization of microemulsion droplets (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoredox-induced polymerization of microemulsion dropletsCarole K. Graetzel, Marie Jirousek, and Michael GraetzelCite this: Langmuir 1986, 2, 3, 292–296Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://doi.org/10.1021/la00069a006RIGHTS & PERMISSIONSArticle Views126Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Multi-Column Convolutional Neural Networks with Causality-Attention for Why-Question Answering (2017)

Why-question answering (why-QA) is a task to retrieve answers (or answer passages) to why-questions (e.g., "why are tsunamis generated?") from a text archive. Several previously proposed methods for why-QA improved their performance by automatically recognizing causalities that are expressed with such explicit cues as "because" in answer passages and using the recognized causalities as a clue for finding proper answers. However, in answer passages, causalities might be implicitly expressed, (i.e., without any explicit cues): "An earthquake suddenly displaced sea water and a tsunami was generated." The previous works did not deal with such implicitly expressed causalities and failed to find proper answers that included the causalities. We improve why-QA based on the following two ideas. First, implicitly expressed causalities in one text might be expressed in other texts with explicit cues. If we can automatically recognize such explicitly expressed causalities from a text archive and use them to complement the implicitly expressed causalities in an answer passage, we can improve why-QA. Second, the causes of similar events tend to be described with a similar set of words (e.g., "seismic energy" and "tectonic plates" for "the Great East Japan Earthquake" and "the 1906 San Francisco Earthquake"). As such, even if we cannot find in a text archive any explicitly expressed cause of an event (e.g., "the Great East Japan Earthquake") expressed in a question (e.g., "Why did the Great East Japan earthquake happen?"), we might be able to identify its implicitly expressed causes with a set of words (e.g., "tectonic plates") that appear in the explicitly expressed cause of a similar event (e.g., "the 1906 San Francisco Earthquake").
Dominant-negative Pes1 mutants induce p53 accumulation in proliferating cells but not in quiescent cells (2011)

<b>Copyright information:</b>Taken from "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex"Nucleic Acids Research 2006;34(10):3030-3043.Published online 31 May 2006PMCID:PMC1474060.© 2006 The Author(s) () Western blot for endogenous p53 levels. Stably transfected TGR-1 cells were induced at subconfluent density for 30 h with doxycycline. Cell lysates were prepared and analysed by immunoblotting for p53 accumulation using anti-p53 antibodies (Pab-240). n.s.: non specific. () Upper panel: western blot as described in (A), but the cells had been serum-starved for 72 h before induction. Lower panel: immunoblot against the HA-tag to confirm the expression of recombinant wt and mutant Pes1. () Analysis of the endogenous p53 response to expression of Pes1 wt, and mutants M1 and M5 by indirect immunofluorescence. Asynchronously proliferating and serum-starved (72 h) cells were treated with doxycycline for 24 h to induce the Pes1 constructs. Cells were fixed in methanol and stained against p53 with anti-p53 (Pab122). Cell nuclei were counterstained with DAPI. Representative images are shown. () Percentage of p53-positive nuclei in TGR-1 cells upon induction of Pes1 wt, and the dominant-negative mutants M1 and M5. Proliferating and serum-starved cells were analysed by immunofluorescence as described in (C). Numbers of examined cells are indicated in brackets. Error bars indicate SD of the percentage of p53-positive nuclei cells.
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites (2021)

HFD drives colorectal tumorigenesis through inducing gut microbial dysbiosis, metabolomic dysregulation with elevated lysophosphatidic acid, and gut barrier dysfunction in mice.
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts (2017)

Efficient delivery of therapeutic nanoparticles (TNPs) to tumors is critical in improving efficacy, yet strategies that universally maximize tumoral targeting by TNP modification have been difficult to achieve in the clinic. Instead of focusing on TNP optimization, we show that the tumor microenvironment itself can be therapeutically primed to facilitate accumulation of multiple clinically relevant TNPs. Building on the recent finding that tumor-associated macrophages (TAM) can serve as nanoparticle drug depots, we demonstrate that local tumor irradiation substantially increases TAM relative to tumor cells and, thus, TNP delivery. High-resolution intravital imaging reveals that after radiation, TAM primarily accumulate adjacent to microvasculature, elicit dynamic bursts of extravasation, and subsequently enhance drug uptake in neighboring tumor cells. TAM depletion eliminates otherwise beneficial radiation effects on TNP accumulation and efficacy, and controls with unencapsulated drug show that radiation effects are more pronounced with TNPs. Priming with combined radiation and cyclophosphamide enhances vascular bursting and tumoral TNP concentration, in some cases leading to a sixfold increase of TNP accumulation in the tumor, reaching 6% of the injected dose per gram of tissue. Radiation therapy alters tumors for enhanced TNP delivery in a TAM-dependent fashion, and these observations have implications for the design of next-generation tumor-targeted nanomaterials and clinical trials for adjuvant strategies.
Development of PMUT Array Packaging from Characterisation Prototypes to Customer Samples (2023)

PMUT (Piezoelectric Micromachined Ultrasonic Transducers) can be used in a wide number of medical and industrial applications, from high-end ultrasound scanning which requires a large array of membranes and interconnects to the ASIC driver/receiver, to therapeutic ultrasound and energy delivery which require a small number of membranes/interconnects. Different packaging needs have been required during the development program for the characterisation of the PMUT devices and the requirements of the different prospective product niches. In this paper, the different packages designed, assembled, and used during the development of the PMUT from the first characterisation packages to the 1st prototype packages that will be used for high resolution ultrasound imaging customer samples are described.
Comparison of efficient interpolation techniques for symbol timing recovery (2002)

There is a trend of using digital receivers where the sampling of the received signal is not synchronized to the incoming data symbols. In these receivers, timing adjustment must be done after sampling using interpolation. There are many different interpolation methods which can be used. We compare three different polynomial-based interpolation methods which can be efficiently implemented using the so-called Farrow (1988) structure. Methods to be compared are the linear and cubic Lagrange interpolation and a new interpolation method proposed earlier by the authors.
Stable Object Reorientation using Contact Plane Registration (2022)

We present a system for accurately predicting stable orientations for diverse rigid objects. We propose to overcome the critical issue of modelling multimodality in the space of rotations by using a conditional generative model to accurately classify contact surfaces. Our system is capable of operating from noisy and partially-observed pointcloud observations captured by real world depth cameras. Our method substantially outperforms the current state-of-the-art systems on a simulated stacking task requiring highly accurate rotations, and demonstrates strong sim2real zero-shot transfer results across a variety of unseen objects on a real world reorientation task.
Diffractive lens design for optimized focusing (2014)

We utilized nonlinear optimization to design phase-only diffractive lenses that focus light to a spot, whose width is smaller than that dictated by the far-field diffraction limit. Although scalar-diffraction theory was utilized for the design, careful comparisons against rigorous finite-difference time-domain simulations confirm the superfocusing effect. We were able to design a lens with a focal spot size that is 25% smaller than that formed by a conventional lens of the same numerical aperture. An optimization strategy that allows one to design such lenses is clearly explained. Furthermore, we performed careful simulations to elucidate the effects of fabrication errors and defocus on the performance of such optimized lenses. Since these lenses are thin, binary, and planar, large uniform arrays could be readily fabricated enabling important applications in microscopy and lithography.
Tyrosine Phosphorylation of BCR by FPS/FES Protein-Tyrosine Kinases Induces Association of BCR with GRB-2/SOS (1995)

The human bcr gene encodes a protein with serine/threonine kinase activity, CDC24/dbl homology, a GAP domain, and an SH2-binding region. However, the precise physiological functions of BCR are unknown. Coexpression of BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells resulted in stable BCR-FES protein complex formation and tyrosine phosphorylation of BCR. Association involves the SH2 domain of FES and a novel binding domain localized to the first 347 amino acids of the FES N-terminal region. Deletion of the homologous N-terminal BCR-binding domain from v-fps, a fes-related transforming oncogene, abolished transforming activity and tyrosine phosphorylation of BCR in vivo. Tyrosine phosphorylation of BCR in v-fps-transformed cells induced its association with GRB-2/SOS, the RAS guanine nucleotide exchange factor complex. These data provide evidence that BCR couples the cytoplasmic protein-tyrosine kinase and RAS signaling pathways.
Microwave Modelling of Photonic Crystals (2004)

This chapter contains sections titled: Fundamentals Maxwell's equations and scaling laws Numerical tools Microwave measurements Scattering matrix Microwave equipment Coupling of coaxial metallic to dielectric strip waveguide Loss measurement of waveguide resonator Experimental results 2D infinite–height PhC 2D finite–height PhC with line–defect waveguide