gebhart/patrepeval huggingface dataset:
High throughput diagnosis of avian influenza : application to surveillance of wild birds (2007)

In the context of highly pathogenic avian influenza (HPAI) emergence in Africa in early 2006, it has become necessary to increase the surveillance level in this region, including surveillance of wild birds suspected to play a role in transmission. A first surveillance campaign was launched in Africa in early 2006, within the framework of a regional Technical Cooperation Programme (TCP) of FAO. It showed a prevalence of 3.3% of LPAI in wild birds out of 5288 samples analysed manually. Here, we present our strategy for the development of a high throughput diagnostic line of AIV. Field collection of samples was carried out by Wetlands International and CIRAD. Cloacal and tracheal swabs collected from wild birds were immediately placed in conservative medium and sent to Montpellier where an automation workstation (Biomek FxP, Beckman) was used for RNA extraction. Specific quantitative RT-PCR were then run to identify influenza A virus positive samples and H5 or H7 subtypes. These subtypes could be further characterized by sequencing of the hemagglutinin cleavage site and by virus isolation. This strategy was successfully applied to wild bird surveillance in Africa and Eastern Europe during winter 2006/2007, within the framework of a second regional TCP of FAO.
Utköp i tillverkningsindustrin 1994-1998. : Vilka strategier används för att försöka skapa ökade värden i målbolagen? (2004)

Denna uppsats ar en undersokning av vilka strategier som utkopta foretag i tillverkningsindustrin anvander for att forsoka oka i varde. Studien bestar av en nyckeltalsanalys med exemplifierande fal ...
Triazine Functionalized Porous Covalent Organic Framework for Photo-organocatalytic E–Z Isomerization of Olefins (2019)

Visible light-mediated photocatalytic organic transformation has drawn significant attention as an alternative process for replacing thermal reactions. Although precious metal/organic dyes based homogeneous photocatalysts have been developed, their toxic and nonreusable nature makes them inappropriate for large-scale production. Therefore, we have synthesized a triazine and a keto functionalized nonmetal based covalent organic framework (TpTt) for heterogeneous photocatalysis. As the catalyst shows significant absorption of visible light, it has been applied for the photocatalytic uphill conversion of trans-stilbene to cis-stilbene in the presence of blue light-emitting diodes with broad substrate scope via an energy transfer process.
Development of Super Thin TSV PoP (2010)

Package on Package (PoP) has emerged as the preferred method to stack logic processor and memory in more advanced mobile phone platforms. One issue with the PoP is that the overall height of the stacked package is thicker than other packages in the digital section of the phone. Reducing the thickness of the PoP solutions is important to reduce the thickness of the mobile phone and to realize the market need for thinner, sleeker products. In addition, a very thin PoP solution could enable the stacking of more than two packages on top of each other (two processor packages with shared memory package on top, for instance). This paper highlights the development of a novel, thin, PoP solution, called the Super Thin TSV PoP. In order to decrease the thickness of the PoP solution, through silicon via (TSV) interposer technology was used as the substrate of the packages. TSV interposer substrates can reduce the thickness of the substrate to 0.1mm, whereas conventional organic based substrates used for PoP are typically 0.3mm thick or more. Also, because the TSV substrate is Si based, it is matching the material property of the logic and memory device itself, thereby warpage due to the mismatch of materials should be minimized. A flip chip PoP daisy chain test vehicle was designed in order to prove the viability of this technology. This test vehicle was a 12×12mm package with 0.4mm ball pitch on the bottom and 0.4mm pitch between the top and bottom PoP package. The die sizes and bump pitch of the flip chip devices are representative and realistic of future emerging logic and memory devices. Electrical simulation was done during the design stage to assure that the layer count and routing of each PoP would meet the specifications and be comparable to future PoP designs. Thermal simulation was also performed and found to be superior to the comparable PoP configuration with organic substrate. The overall height of Super Thin TSV PoP is 0.7mm with one memory device mounted on the top package. More memory die-stacked on the top package and potentially higher density pitch package to package is envisioned for future implementations. This paper will highlight the development and assembly of the Super Thin TSV PoP test vehicle, challenges encountered and overcome, and future steps.
Left Ventricular Wall Reconstruction with Autologous Vascularized Tunica Muscularis of Stomach in a Porcine Pilot Model (2022)

The clinical results and the observed physiological integration of gastric grafts into the cardiac structure demonstrate the feasibility of vascularized stomach tissue as myocardial prosthesis. The physiological remodeling indicates a regenerative potential of the graft. Above all, the connection of the gastric vessels with the coronary system constitutes a rationale for the use of vascularized and, therefore, viable stomach tissue for versatile tissue engineering applications.
Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere (1993)

A number of potential HIV protease inhibitory peptides that contain the dihydroxyethylene isostere were prepared and evaluated for their enzyme binding affinity and antiviral activity in cell cultures. From the template of a previously reported active peptide A, modifications at the N- and C-terminal groups were assessed for potential maintenance of good inhibitory activity of the resulting peptides. Among the active peptides found, peptide XVIII exhibited potent enzyme inhibitory activity. Interestingly, the previously reported, effective 1(S)-amino-2(R)-hydroxyindan C-terminal group for the preparation of very active HIV protease inhibitory peptides could not be applied to the template of peptide XVIII. Molecular modeling of peptide XVIII was studied using the X-ray crystal structure of peptide A as a starting point in order to study the likely conformation of peptide XVIII in the active-site cleft. Relative binding conformations of peptide A and XVIII were obtained, although the reason for poor binding affinity for a number of congeneric peptides in this report was not straightforwardly apparent. More importantly, however, peptide XVIII was found to exhibit more effective antiviral activity in the HIV-1/PBMC assay than the reference peptide A which was previously reported to be approximately equal in efficacy to the reverse transcriptase inhibitor AZT in this assay.
Ultrashort-pulse generation and amplification in Ti:sapphire (2002)

In conclusion, we have demonstrated a simple and reliable Ti:sapphire laser amplifier capable of generating pulses of unprecedented short duration. Our results confirm the fact that third-order dispersion is the primary factor limiting pulse duration in these lasers. Also, chirped-pulse amplification designs capable of propagating sub-2O fs pulses have been tested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Phase II Trial of Weekly Bortezomib in Combination with Rituximab in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia. (2009)

Abstract Abstract 2727 Poster Board II-703 INTRODUCTION: This study aimed to determine activity and safety of weekly bortezomib and rituximab in patients with relapsed/refractory Waldenstrom's Macroglobulinemia (WM). METHODS: Patients who had at least one previous therapy were eligible. All patients received bortezomib IV weekly at 1.6 mg/m2 on days 1, 8, 15, q 28 days x 6 cycles, and rituximab 375 mg/m2 weekly on cycles 1 and 4. Primary endpoint was the percent of patients with at least a minor response. RESULTS: Thirty-seven patients were treated. Majority of patients (78%) completed treatment per protocol. At least minimal response (MR) or better was observed in 81% (95% CI: [65,92]) with 2 patients (5%) in complete remission (CR)/near CR, 17 (46%) in partial response (PR), and 11(30%) in MR. The median time to progression was 16.4 months (95% CI, 11.4–21.1). Death occurred in 1 patient due to viral pneumonia. The most common grade 3 and 4 therapy related adverse events included reversible neutropenia in 16%, anemia in 11%, and thrombocytopenia in 14%. Grade-3 peripheral neuropathy occurred in only 2 patients (5%). The median event-free survival (EFS) is 12 months (95% CI, 11–20) with estimated 12 month and 18 month EFS of 49% (95% CI: [31, 67%]) and 38% (95% CI: [20, 56%]). The median overall survival has not been reached. CONCLUSIONS: The combination of weekly bortezomib and rituximab showed significant activity and minimal neurological toxicity in patients with relapsed WM. Disclosures: Ghobrial: Millennium: Honoraria, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Speakers Bureau; Novartis: Honoraria, Speakers Bureau. Anderson:Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Richardson:Millennium Pharmaceuticals, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Johnson and Johnson: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Keryx: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; BMS: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Treon:Millennium: Honoraria, Research Funding, Speakers Bureau; Celgene: Honoraria, Research Funding, Speakers Bureau; Genentech: Honoraria, Research Funding, Speakers Bureau. Matous:Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees; Cephalon: Membership on an entity's Board of Directors or advisory committees.
High-speed oversampled continuous-time analog-to-digital converters (2017)

Oversampled continuous-time analog-to-digital converters are on the verge of surpassing the bandwidth of their discrete-time counterparts as their sampling rates continue to increase while recent innovative architectures have reduced their oversampling ratios. This paper outlines several architectures that have led to these improvements, which include single-loop ΔΣ modulators, cascaded or MASH ΔΣ modulators, and pipeline data converters.
Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries (2018)

Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity. However, the synthesis of libraries of large random RNAs is still difficult and expensive. The engineering of polymerases able to directly generate these libraries has the potential to replace the chemical synthesis approach. Here, we start with a DNA polymerase that already displays a significant template-free nucleotidyltransferase activity, human DNA polymerase theta, and we mutate it based on the knowledge of its three-dimensional structure as well as previous mutational studies on members of the same polA family. One mutant exhibited a high tolerance towards ribonucleotides (NTPs) and displayed an efficient ribonucleotidyltransferase activity that resulted in the assembly of long RNA polymers. HPLC analysis and RNA sequencing of the products were used to quantify the incorporation of the four NTPs as a function of initial NTP concentrations and established the randomness of each generated nucleic acid sequence. The same mutant revealed a propensity to accept other modified nucleotides and to extend them in long fragments. Hence, this mutant can deliver random natural and modified RNA polymers libraries ready to use for SELEX, with custom lengths and balanced or unbalanced ratios.
Proteasome Activator PA200 Is Required for Normal Spermatogenesis (2006)

The PA200 proteasome activator is a broadly expressed nuclear protein. Although how PA200 normally functions is not fully understood, it has been suggested to be involved in the repair of DNA double-strand breaks (DSBs). The PA200 gene (Psme4) is composed of 45 coding exons spanning 108 kb on mouse chromosome 11. We generated a PA200 null allele (PA200(Delta)) through Cre-loxP-mediated interchromosomal recombination after targeting loxP sites at either end of the locus. PA200(Delta/Delta) mice are viable and have no obvious developmental abnormalities. Both lymphocyte development and immunoglobulin class switching, which rely on the generation and repair of DNA DSBs, are unperturbed in PA200(Delta/Delta) mice. Additionally, PA200(Delta/Delta) embryonic stem cells do not exhibit increased sensitivity to either ionizing radiation or bleomycin. Thus, PA200 is not essential for the repair of DNA DSBs generated in these settings. Notably, loss of PA200 led to a marked reduction in male, but not female, fertility. This was due to defects in spermatogenesis observed in meiotic spermatocytes and during the maturation of postmeiotic haploid spermatids. Thus, PA200 serves an important nonredundant function during spermatogenesis, suggesting that the efficient generation of male gametes has distinct protein metabolic requirements.
Increased heat tolerance afforded by oil-based conidial formulations of Metarhizium anisopliae and Metarhizium robertsii (2017)

The thermotolerance of oil-based conidial formulations of Metarhizium anisopliae s.l. (IP 46) and Metarhizium robertsii (ARSEF 2575) were investigated. Conidia of IP 46 or ARSEF 2575 were suspended in different adjuvants and exposed to 45 ± 0.2°C for 4, 6, 8 or 24 h; their viability was then assessed after 48 h incubation at 27 ± 1°C. Conidia heated in pure mineral or vegetable oil exhibited mean relative viability exceeding 70% after 8 h of heat exposure, whereas low germination (≤20%) was observed when conidia were heated in water (Tween 80® 0.01%), carboxymethyl cellulose gel or emulsifiable oils (Graxol® or Assist®) and exposed to heat for 6 or 8 h. In addition, conidia of IP 46 suspended in either pure mineral or canola oil and exposed to heat for 48 h had moderate viability, 57% or 41%, respectively. Unstable oil-in-water emulsions showed a higher percentage of conidia incorporated into oil micellae, while the stable emulsions had higher percentage of conidia outside the oil micellae. The thermotolerance of conidia formulated in stable emulsions, however, did not differ from that of conidia formulated in unstable emulsions. The present study highlights possibilities to alleviate the deleterious effects of heat stress towards Metarhizium spp. conidia applied for controlling arthropod pests and vectors through oil-based formulations.
Appendices A--D (2002)

article Appendices A--D: A scalable method for deductive generalization in the spreadsheet paradigm Share on Authors: Margaret Burnett Oregon State University Oregon State UniversityView Profile , Sherry Yang Oregon Institute of Technology Oregon Institute of TechnologyView Profile , Jay Summet Oregon State University Oregon State UniversityView Profile Authors Info & Claims ACM Transactions on Computer-Human InteractionVolume 9Issue 4December 2002 pp 1–5https://doi.org/10.1145/586081.586082Published:01 December 2002 0citation420DownloadsMetricsTotal Citations0Total Downloads420Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Site-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia-afflicted and pain-free women (2015)

Fibroblast strains were derived from 2 regions of the lower genital tract of localized provoked vulvodynia (LPV) cases and pain-free controls. Sixteen strains were derived from 4 cases and 4 controls, age and race matched, after presampling mechanical pain threshold assessments. Strains were challenged with 6 separate stimuli: live yeast species (Candida albicans, Candida glabrata, Candida tropicalis, and Saccharomyces cerevisiae), yeast extract (zymosan), or inactive vehicle. Production of prostaglandin E2 (PGE2) and interleukin 6 (IL-6) were proinflammatory response measures. Highest IL-6 and PGE2 occurred with vestibular strains after C albicans, C glabrata, and zymosan challenges, resulting in the ability to significantly predict IL-6 and PGE2 production by genital tract location. After C albicans and C glabrata challenge of all 16 fibroblast strains, adjusting for dual sampling of subjects, PGE2 and IL-6 production significantly predicted the presampling pain threshold from the genital tract site of sampling. At the same location of pain assessment and fibroblast sampling, in situ immunohistochemical (IHC)(+) fibroblasts for IL-6 and Cox-2 were quantified microscopically. The correlation between IL-6 production and IL-6 IHC(+) was statistically significant; however, biological significance is unknown because of the small number of IHC(+) IL-6 fibroblasts identified. A low fibroblast IL-6 IHC(+) count may result from most IL-6 produced by fibroblasts existing in a secreted extracellular state. Enhanced, site-specific, innate immune responsiveness to yeast pathogens by fibroblasts may be an early step in LPV pathogenesis. Fibroblast strain testing may offer an attractive and objective marker of LPV pathology in women with vulvodynia of inflammatory origin.
Improved Lost Circulation Treatment Design and Testing Techniques Minimize Formation Damage (2011)

Abstract Most subterranean rocks contain natural fractures. Fluid loss severity in reservoir sections increases with increasing width of the fractures. Apart from the economics of lost drilling fluids, preventing formation damage in the reservoir section is of paramount importance. The application of non-damaging lost circulation material (LCM) has been the traditional solution to control losses in these scenarios. The performance of such LCM mixtures is usually determined with a Particle Plugging Apparatus (PPA), using aloxide discs for evaluating fluid loss. These discs more closely emulate a permeable sandstone, with varying pore throat sizes, than a natural fracture. The formation of an impermeable plug which can sustain higher wellbore pressure is desirable when treating a fracture, but in a producing formation the plug is removed by the produced fluid or by a remedial treatment. To better emulate both natural and induced fracture geometry, slotted discs of constant width were introduced; however these slots represent only the face of the fracture where LCM forms the bridge. The bridge may become eroded due to shear stress of the drilling fluid, leading to reestablishment of lost circulation. To remove these limitations, a new tapered slot was designed in which the fracture opening size varies from its face to its endpoint over a certain length, more closely resembling a fracture. Different combinations of ground marble (acid-soluble) were tested using the tapered slot. Many times it was observed that although the slot was completely filled with LCM, there was continued fluid loss. Considering this, components of high fluid loss pills for such application need to be redesigned. Cellulosic and polylactide (PLA) fibres (5-15% V/V of LCM) were used in combination with particulates resulting in significant improvement in fluid loss control. Other mechanical properties of particulate material were also studied and their importance in controlling lost circulation control established. This paper reviews the application of this testing equipment and methodology with non-damaging fibers for lost circulation control to minimize formation damage in reservoir sections.
The Tension Leg Platform: from Hutton to Big Foot (2020)

Abstract This paper is one of seven papers that will be included in the special session: Floating Memories – Look Back to Leap Forward. The focus for this paper is on the Tension Leg Platform (TLP), one of the four major platform types that include the Floating Production Storage and Offloading platform (FPSO), the semisubmersible floating production system (Semi) and the Spar platform. The paper summarizes the evolution of the TLP over three and half decades, and provides a thirty-five year retrospective of the progression of TLP technology, including hull shapes, tendon connectors, flex elements, and riser systems. It will walk through the evolution of understanding, analytical methods, and model testing to assess the complex global performance of a TLP, and the unique challenges of system dynamic resonant excitation, the so-called "ringing" and "springing" phenomena. The TLP was a game-changer in bringing dry tree wells to floating platforms, leveraging dry tree drilling and well control methods from a generation of fixed platforms, and enabling multiple top- tensioned production and drilling risers in close proximity due to the limited tensioner stroke not possible on a drill ship or semisubmersible. The TLP has shown its applicability in water depths from the Hutton TLP (1982) in barely 150 m of water in the North Sea, to the Big Foot TLP installed in 1584 m of water in the Gulf of Mexico in 2018, the deepest TLP to date. And it has shown its flexibility in size ranging from the smallest mini-TLP's of 10,000 tonnes displacement, to the North Sea concrete hulled Heidrun TLP of 290,000 tonnes.
Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis. (1995)

The finding that perinuclear antineutrophil cytoplasmic antibodies occur more frequently in patients with chronic pouchitis raises the possibility that this antibody may mark a genetically distinct subset of ulcerative colitis patients. Further studies are needed to determine whether the presence of this antibody before ileal pouch-anal anastomosis is predictive for later development of chronic pouchitis.