gebhart/patrepeval huggingface dataset:
High-order dispersion in Kerr comb oscillators (2017)

We numerically investigate the effect of high-order dispersion on Kerr frequency comb generation in optical microresonators characterized with anomalous group velocity dispersion (GVD) using realistic slot-waveguide-based silicon nitride microring and spheroidal crystalline magnesium fluoride resonators. Our numerical simulations indicate that all orders of GVD should be taken into account to obtain the correct envelope shape of the generated Kerr frequency comb. High-order GVD affects the 3 dB comb bandwidth, nonlinear conversion efficiency, and frequency recoil of the comb spectrum (i.e., spectral shift effect), as well as pulse peak power and the power dependence of the pulse timing. Additionally, high-order dispersion terms affect the spectral position of a dispersive wave generated in a microresonator. Our results emphasize the influence of the pump power on the dispersive wave radiation frequency as well as the repetition rate of the generated frequency comb. The latter has significant practical ramifications, for instance, for the use of resonator-based frequency combs in optical clocks. We also observe competition in the generation of two different pulses corresponding to nearly the same spectral envelope. These mode-locked combs appear in the presence of a strong negative fourth-order GVD; one of them takes a hyperbolic-secant soliton shape, while the other resembles a Gaussian pulse superimposed on a modulated pedestal. The appearance and stability of the latter pulse depend on the numerical integration technique utilized.
Single-lobe surface-emitting quantum cascade laser with 2nd-order metal-semiconductor gratings (2015)

Grating-coupled, surface-emitting (GCSE) quantum-cascade lasers (QCLs) have been studied since 2000 [1] and generally operate in a two-lobe beam pattern [1,2]. Recently, single-lobe surface emission has been reported either from asymmetrically-coated devices [3] or from chirped-grating, ring-cavity devices [4], but at powers ≤ 0.1 W. Here we present the implementation of a novel concept for high-power, single-lobe surface emission, which employs metal-semiconductor, 2nd-order distributed feedback (DFB) gratings [5]. Initial devices demonstrate ~ 0.4 W single-lobe, single-mode power from 4.75 μm-emitting GCSE QCLs.
Keep Calm and Don’t Switch: About the Relationship Between Switches and Quality in HAS (2017)

Video streaming has established itself as the main method to consume multimedia content on the Internet. The most widespread technique is HTTP Adaptive Streaming which is used by large video service platforms such as YouTube and Netflix. In order to guarantee a high QoE, different adaptation strategies have been developed that lead to different video playout patterns. While some strategies may be more aggressive than others and often adapt the video quality, it is not clear which strategy is the best.,,In this paper, we want to identify the trade-off between the average video quality and switches in the quality during playout. We do this with a user-centric view and try to optimize the adaptation depending on the user preference with a quadratic program. This work allows to put existing and future video adaptation algorithms in perspective with respect to user preferences. Our results show that the video quality can already be increased greatly by allowing few switches while more switches lead to diminishing gains. This is a novel discovery that is important for user-centric QoE-management which is of high interest for ISPs and video service providers.
Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic β‐cells (2006)

Amylin-mediated islet beta-cell death is implicated in diabetogenesis. We previously reported that fibrillogenic human amylin (hA) evokes beta-cell apoptosis through linked activation of Jun N-terminal kinase 1 (JNK 1) and a caspase cascade. Here we show that p38 kinase [p38 mitogen-activated protein (MAP) kinase] became activated by hA treatment of cultured beta-cells whereas extracellular signal-regulated kinase (ERK) did not; by contrast, nonfibrillogenic rat amylin (rA) altered neither. Pretreatment with the p38 kinase-inhibitor SB203580 decreased hA-induced apoptosis and caspase-3 activation by approximately 30%; as did combined SB203580 and JNK inhibitor I, by about 70%; and the combination of SB203580, the JNK inhibitor I and a caspase-8 inhibitor, by 100%. These findings demonstrate the requirement for concurrent activation of the p38 kinase, JNK and caspase-8 pathways. We further showed that hA elicits time-dependent activation of activating transcription factor 2 (ATF-2), which was largely suppressed by SB203580, indicating that this activation is catalyzed mainly by p38 kinase. Furthermore, hA-induced apoptosis was suppressed by specific antisense ATF-2, and increased phospho-ATF-2 (p-ATF-2) was associated with increased CRE (cAMP-response element) DNA binding and CRE-mediated transcriptional activity, as well as enhancement of c-jun promoter activation. We also detected changes in the phosphorylation status and composition of the CRE complex that may play important roles in regulation of distinct downstream target genes. These studies establish p38 MAP kinase-mediated activation of ATF-2 as a significant mechanism in hA-evoked beta-cell death, which may serve as a target for pharmaceutical intervention and effective suppression of beta-cell failure in type-2 diabetes.
Characterization of a Functional Soluble Form of a Brassica napus Membrane-Anchored Endo-1,4-β-Glucanase Heterologously Expressed in Pichia pastoris (2001)

The Brassica napus gene, Cel16, encodes a membrane-anchored endo-1,4-beta-glucanase with a deduced molecular mass of 69 kD. As for other membrane-anchored endo-1,4-beta-glucanases, Cel16 consists of a predicted intracellular, charged N terminus (methionine(1)-lysine(70)), a hydrophobic transmembrane domain (isoleucine(71)-valine(93)), and a periplasmic catalytic core (lysine(94)-proline(621)). Here, we report the functional analysis of Delta(1-90)Cel16, the N terminally truncated Cel16, missing residues 1 through 90 and comprising the catalytic domain of Cel16 expressed recombinantly in the methylotrophic yeast Pichia pastoris as a soluble protein. A two-step purification protocol yielded Delta(1-90)Cel16 in a pure form. The molecular mass of Delta(1-90)Cel16, when determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, was about 130 kD and about 60 kD after enzymatic removal of N-glycans, fitting the expected molecular mass of 59 kD. Delta(1-90)Cel16 was highly N glycosylated as compared with the native B. napus Cel16 protein. Delta(1-90)Cel16 had a pH optimum of 6.0. The activity of Delta(1-90)Cel16 was inhibited by EDTA and exhibited a strong dependence on calcium. Delta(1-90)Cel16 showed substrate specificity for low substituted carboxymethyl-cellulose and amorphous cellulose. It did not hydrolyze crystalline cellulose, xyloglycan, xylan, (1-->3),(1-->4)-beta-D-glucan, the highly substituted hydroxyethylcellulose, or the oligosaccharides cellotriose, cellotetraose, cellopentaose, or xylopentaose. Size exclusion analysis of Delta(1-90)Cel16-hydrolyzed carboxymethylcellulose showed that Delta(1-90)Cel16 is a true endo-acting glucanase.
Selective detection of Cr(vi) in aqueous media by carbazole-based fluorescent organic microcrystals (2011)

Taking advantage of its high luminescence as an aggregate, 1-cyano-trans-1,2-bis-(4-carbazolyl)-phenylethylene (CN-CPE) was evaluated as an electron-transfer probe for sensing of Cr(VI) in aqueous media. A remarkable Cr(VI)-sensitivity and selectivity over common aqueous interferents was found.
Comprar Handbook Of Optical Systems, Vol. 5: Metrology Of Optical Components And Systems | B. Dorband | 9783527403813 | Wiley (2012)

Tienda online donde Comprar Handbook Of Optical Systems, Vol. 5: Metrology Of Optical Components And Systems al precio 277,83 € de B. Dorband | H. Muller | H. Gross, tienda de Libros de Medicina, Libros de Oftalmologia y Optica - Optica
Controlled Redox and Electrical Properties in Polyheterocycles (2000)

Abstract : Electrochromic and conducting polymers may prove especially important for a number of Air Force applications including chameleon coatings, informational displays, IR and microwave attenuation, dialed tint windows, and gap sealants. We are developing conjugated, redox active, and conducting polymers with controllable electronic band gaps that range from 1.1 eV to 4.0 eV, thus spanning from the NIR, through the entire visible spectrum, and into the UV. We have developed a reproducible method by which electrochromic coloration efficiencies (CE) can be measured accurately for polymer films. We have investigated the use of BF3 ethyl etherate as an alterative media for the electrochemical synthesis of highly electroactive polymer films and shown it to be applicable to preparing high quality polythiophene and donor-acceptor polymers which can be n-type doped. Electrochromic devices (ECD's) with especially high color contrasts between bleached and colored states have been developed. We have broadened the visible absorption in polymer ECD's while retaining the high contrast by having two cathodically coloring polymers with different Lambda(sub max) values deposited as a bilayer on a single electrode. Functionalized 3,4-propylenedioxythiophene polymers have been developed as soluble conducting polymers for blending into elastomeric hosts and as solution processable high contrast electrochromic polymers. We have prepared multi-color electrochromic and red emitting polymers through the synthesis of soluble low band gap polymers containing conjugated donor and acceptor units.
Exploring single-molecule SERS and single-nanoparticle plasmon microscopy (2009)

In this work we perform correlated structural and optical studies of single nanoparticles as well as explore the generality of SMSERS. First, wide-field plasmon resonance microscopy is used to simultaneously determine the LSPR spectra of multiple Ag nanoprisms, whose structure is determined using TEM. Next, the structure-property relationships for well-defined and easily-controlled nanoparticle structures (e.g. monomers, dimers, and trimers) are studied using correlated TEM, LSPR, and SERS measurements of individual SERS nanotags. We present the SER spectrum of reporter molecules on a single nanotag comprised of a Au trimer. It was determined that of 40 individual nanotags, just 19 exhibited SERS. The remaining nanoparticles were established by TEM to be monomers. These results demonstrate that SERS signal is observed from individual nanotags containing a junction or hot spot. Lastly, we explore crystal violet, a triphenyl methane dye that was used in the seminal SMSERS investigations, and re-examine single-molecule sensitivity using the isotopologue approach.
A kettészakadt híd – Csernok Attila új könyve finn nyelven (2014)

A sokak által ismert – szeretett és gyűlölt – író-közgazdász Csernok Attila új kötete, A kettészakadt híd - Magyarország elfelejtett történelme címmel, az elmúlt hetekben jelent meg Finnországban.
Abstract 3007: Glycoprotein IIb/IIIa Inhibitors before Primary Percutaneous Coronary Intervention of ST-Elevation Myocardial Infarction Improve Perfusion and Outcomes: Insights from APEX-AMI (2007)

Background: APEX-AMI provides a unique contemporary opportunity to explore the influence of glycoprotein IIb/IIIa inhibitors (GPIs) and their timing on myocardial perfusion and outcomes in STEMI pt...
Folate Receptor-β in Activated Macrophages: Ligand Binding and Receptor Recycling Kinetics (2014)

Activated macrophages overexpress a receptor for the vitamin folic acid termed the folate receptor β (FR-β). Because conjugation of folate to low molecular weight drugs, genes, liposomes, nanoparticles, and imaging agents has minor effects on FR binding, the vitamin can be exploited to target both therapeutic and imaging agents to activated macrophages without promoting their uptake by other healthy cells. In this paper, we characterize the binding, internalization, and recycling kinetics of FR-β on activated macrophages in inflamed tissues of rats with adjuvant-induced arthritis. Our results demonstrate that saturation of macrophage FR is achieved at injection doses of ∼150-300 nmol/kg, with more rapidly perfused tissues saturating at lower doses than inflamed appendages. After binding, FR-β internalizes and recycles back to the cell surface every ∼10-20 min, providing empty receptors for additional folate conjugate uptake. Because the half-life of low molecular weight folate conjugates in the vasculature is usually <1 h, these data suggest that targeting of folate conjugates to activated macrophages in vivo can be maximized by frequent dosing at conjugate concentrations that barely saturate FR (∼150 nmol/kg), thereby minimizing nonspecific binding to receptor-negative tissues and maximizing the probability that unoccupied cell surface receptors will be exposed to folate-drug conjugate.
The Importance of the Primary Reconstruction of the Traumatized Anterior Maxillary Sinus Wall (2008)

This study evaluates the importance of specific posttraumatic reconstruction of the fractured anterior sinus wall. Several methods of different complexity of reconstruction are being compared by means of radiologic, rhinoscopic, and clinical data. Four groups of a total of 207 patients (age, 18-73 years; follow-up average, 4.2 years) with midfacial fractures, divided by operation technique and year, were evaluated. Control groups 1 to 3 received standard procedures without special regard on the reconstruction of the anterior sinus wall; the study group received specific reconstruction. The study group 4 showed a lower complication rate in nearly all measured parameters in comparison to groups 1 and 2. Study group 4 had the smallest incidences of posttraumatic sequelae in radiologic examinations; the clinical outcome was even to group 3. During open reduction and fixation procedures of midfacial fractures, attention should be given to the reconstruction of the anterior sinus wall to avoid postoperative discomfort.
Stereospecific protonative deconjugation of alkyl 3-trimethylstannylalk-2-enoates (1985)

Treatment of the β-trimethylstannyl α,β-unsaturated esters (3)–(8) with lithium di-isopropylamide in tetrahydrofuran (THF)[(3)–(5)] or THF–hexamethylphosphoramide [(6)–(8)], followed, in each case, by transfer of the resultant solution to a cold (–98 °C) solution of acetic acid in ether, provides exclusively the alkyl 3-trimethylstannylalk-3-enoates (9)–(14), respectively.
A testbed for wide-field, high-resolution, gigapixel-class cameras (2013)

The high resolution and wide field of view (FOV) of the AWARE (Advanced Wide FOV Architectures for Image Reconstruction and Exploitation) gigapixel class cameras present new challenges in calibration, mechanical testing, and optical performance evaluation. The AWARE system integrates an array of micro-cameras in a multiscale design to achieve gigapixel sampling at video rates. Alignment and optical testing of the micro-cameras is vital in compositing engines, which require pixel-level accurate mappings over the entire array of cameras. A testbed has been developed to automatically calibrate and measure the optical performance of the entire camera array. This testbed utilizes translation and rotation stages to project a ray into any micro-camera of the AWARE system. A spatial light modulator is projected through a telescope to form an arbitrary object space pattern at infinity. This collimated source is then reflected by an elevation stage mirror for pointing through the aperture of the objective into the micro-optics and eventually the detector of the micro-camera. Different targets can be projected with the spatial light modulator for measuring the modulation transfer function (MTF) of the system, fiducials in the overlap regions for registration and compositing, distortion mapping, illumination profiles, thermal stability, and focus calibration. The mathematics of the testbed mechanics are derived for finding the positions of the stages to achieve a particular incident angle into the camera, along with calibration steps for alignment of the camera and testbed coordinate axes. Measurement results for the AWARE-2 gigapixel camera are presented for MTF, focus calibration, illumination profile, fiducial mapping across the micro-camera for registration and distortion correction, thermal stability, and alignment of the camera on the testbed.
Factores asociados a conductas promotoras de salud en adolescentes chilenos (2014)

Health promoting behaviors in these children are related to a better academic achievement and a higher integration with school environment.
De-rendering the World's Revolutionary Artefacts (2021)

Recent works have shown exciting results in unsupervised image de-rendering -- learning to decompose 3D shape, appearance, and lighting from single-image collections without explicit supervision. However, many of these assume simplistic material and lighting models. We propose a method, termed RADAR, that can recover environment illumination and surface materials from real single-image collections, relying neither on explicit 3D supervision, nor on multi-view or multi-light images. Specifically, we focus on rotationally symmetric artefacts that exhibit challenging surface properties including specular reflections, such as vases. We introduce a novel self-supervised albedo discriminator, which allows the model to recover plausible albedo without requiring any ground-truth during training. In conjunction with a shape reconstruction module exploiting rotational symmetry, we present an end-to-end learning framework that is able to de-render the world's revolutionary artefacts. We conduct experiments on a real vase dataset and demonstrate compelling decomposition results, allowing for applications including free-viewpoint rendering and relighting.
Interobserver Agreement for the Diagnosis of Venous Thromboembolism on Computed Tomography Chest Angiography and Indirect Venography of the Lower Extremities in Emergency Department Patients (2006)

Objectives: To determine interobserver agreement between radiologists for computed tomography (CT) angiography and venography. CT venography of the lower extremities combined with standard CT angiography of the chest may result in an increased overall diagnosis rate of venous thromboembolism (pulmonary embolism or deep venous thrombosis). Methods: The study had a retrospective cohort design. The population consisted of emergency department patients who were evaluated for suspected pulmonary embolism. A random sample of 50 patients diagnosed and treated for venous thromboembolism and 50 age- and gender-matched patients whose CT angiograms and venograms were read as negative were enrolled. The original reading (R1) was compared with readings of two study radiologists: R2, a general radiologist, and R3, a radiologist with fellowship training in cross-sectional imaging. All readers were blinded to each other. Results: Both R2 and R3 found both CT angiogram and venogram components technically adequate in 95% (95% CI = 89% to 98%) and 86% (95% CI = 78% to 92%) of studies, respectively. The agreement was very good for CT angiography (lowest agreement = 92%; lowest κ= 0.83) and was good for CT venography (85%, κ= 0.65). In nine cases, R1 read the CT angiogram as negative but the venogram as positive for DVT, whereas both R2 and R3 read both components as negative in four of these nine, suggesting a false-positive isolated DVT rate of 44% (95% CI = 19% to 73%). In no case did R1 read both scan components as negative when R2 and R3 agreed on presence of pulmonary embolism or DVT. Conclusions: Diagnosis of pulmonary embolism on CT angiography is more reliable than diagnosis of isolated DVT on CT venography.
Ineffectiveness of High-dose Methylprednisolone in Preventing Parenchymal Lung Injury and Improving Mortality in Patients with Septic Shock (1988)

We conducted a prospective, randomized, double-blind study to determine whether high-dose methylprednisolone could prevent parenchymal lung injury, including the adult respiratory distress syndrome (ARDS), or improve mortality when administered early in septic shock. All patients already hospitalized in or newly admitted to the medical and surgical intensive care units at San Francisco General Hospital between September 1, 1983 and August 29, 1986 were eligible for admission to the study if they had either (1) an increase in temperature of 1.5 degrees C and a decrease in systolic blood pressure of 20 mm Hg or more from baseline values (in already hospitalized patients), or (2) a temperature greater than 38.5 degrees C or less than 35.5 degrees C and a systolic blood pressure of less than 90 mm Hg (in newly admitted patients). Patients meeting these criteria were excluded if they (1) had severe immunodeficiency, (2) were less than 18 or greater than 76 yr of age, (3) had multilobar roentgenographic infiltrates, or (4) were already receiving corticosteroids. Eighty-seven patients enrolled in the study received either methylprednisolone, 30 mg/kg per dose, or mannitol placebo for a total of 4 doses every 6 h, following the presumptive diagnosis of septic shock. Of these patients, 75 ultimately were determined on the basis of culture results to have actually had septic shock at the time of entry. Thirteen of the patients who received methylprednisolone developed ARDS, compared to 14 patients who received placebo. Lesser degrees of parenchymal lung injury did not differ between the 2 groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Why Do You Spread This Message? Understanding Users Sentiment in Social Media Campaigns (2014)

Twitter has been increasingly used for spreading messages about campaigns. Such campaigns try to gain followers through their Twitter accounts, influence the followers and spread messages through them. In this paper, we explore the relationship between followers’ sentiment towards the cam-paign topic and their rate of retweeting of messages gener-ated by the campaign. Our analysis with followers of mul-tiple social-media campaigns found statistical significant correlations between such sentiment and retweeting rate. Based on our analysis, we have conducted an online inter-vention study among the followers of different social-media campaigns. Our study shows that targeting followers based on their sentiment towards the campaign can give higher re-tweet rate than a number of other baseline approaches.
Event Detection Algorithm for Single Sensor Bladder Pressure Data (2016)

Diagnosis of lower urinary tract (LUT) dysfunction with urodynamics has historically relied on data acquired from multiple sensors using nonphysiologically fast cystometric filling.Meanwhile, state-of-the-art treatments for bladder overactivity involving neuromodulation of LUT nerves rely on constant, open-loop stimulation because automated tools for analyzing single-sensor pressure data are not available.Using bladder pressure recordings from 14 human subjects, we have developed Context Aware Thresholding (CAT), a tunable algorithmic framework capable of real-time bladder event classification from single-sensor pressure data.We compare six event detection algorithms using a metric termed Conditional Stimulation Score, which projects stimulation efficacy and efficiency.We demonstrate that algorithms employing adaptive thresholding methods are more robust against daily variations than static thresholds, and that compared to other methods, CAT is fast, robust, noise-tolerant, highlyaccurate, and amenable to energy-efficient hardware implementation.To the best of our knowledge, this is the first effort towards real-time detection of meaningful bladder events which can be used in both diagnosis and treatment of urinary incontinence.viii