gebhart/patrepeval huggingface dataset:
Interference Management in Full-Duplex Cellular Networks With Partial Spectrum Overlap (2017)

Full-duplex (FD) communication is promoted to double the spectral efficiency when compared with the half-duplex counterpart. In the context of cellular networks, however, FD communication exacerbates the aggregate uplink (UL) and downlink (DL) interference, which diminishes the foreseen FD gains. This paper considers a flexible duplex system, denoted by α-duplex system, wherein a fine-grained bandwidth control for each UL/DL channel pair in each base station (BS) is allowed, which also leads to partial spectrum overlap between the UL and DL channels. This paper addresses the resulting interference management problem by maximizing a network-wide rate-based utility function subject to UL/DL power constraints, so as to determine user-to-BS association, user-to-channel scheduling, the UL and DL transmit powers, and the fraction of spectrum overlap between UL and DL for every user, under the assumption that the number of available channels and users is equal. This paper solves such a non-convex mixed-integer optimization problem in an iterative way by decoupling the problem into several sub-problems. Particularly, the user-to-BS association problem is solved using a matching algorithm that is a generalization of the stable marriage problem. The scheduling problem is solved by an iterative Hungarian algorithm. The power and spectrum overlap problem is solved by successive convex approximation. The proposed iterative strategy guarantees an efficient one-to-one user to BS and channel assignment. It further provides optimized flexible duplexing and power allocation schemes for all transceivers. Simulations results show appreciable gains when comparing the proposed solution with different schemes from the literature.
Why Do Adversarial Attacks Transfer? Explaining Transferability of\n Evasion and Poisoning Attacks (2018)

Transferability captures the ability of an attack against a machine-learning\nmodel to be effective against a different, potentially unknown, model.\nEmpirical evidence for transferability has been shown in previous work, but the\nunderlying reasons why an attack transfers or not are not yet well understood.\nIn this paper, we present a comprehensive analysis aimed to investigate the\ntransferability of both test-time evasion and training-time poisoning attacks.\nWe provide a unifying optimization framework for evasion and poisoning attacks,\nand a formal definition of transferability of such attacks. We highlight two\nmain factors contributing to attack transferability: the intrinsic adversarial\nvulnerability of the target model, and the complexity of the surrogate model\nused to optimize the attack. Based on these insights, we define three metrics\nthat impact an attack's transferability. Interestingly, our results derived\nfrom theoretical analysis hold for both evasion and poisoning attacks, and are\nconfirmed experimentally using a wide range of linear and non-linear\nclassifiers and datasets.\n
Generation and Analysis of GluR5(Q636R) Kainate Receptor Mutant Mice (1999)

The physiological significance of RNA editing of transcripts that code for kainate-preferring glutamate receptor subunits is unknown, despite the fact that the functional consequences of this molecular modification have been well characterized in cloned receptor subunits. RNA editing of the codon that encodes the glutamine/arginine (Q/R) site in the second membrane domain (MD2) of glutamate receptor 5 (GluR5) and GluR6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single-channel conductances. Approximately 50% of the GluR5 subunit transcripts from adult rat brain are edited at the Q/R site in MD2. To address the role of glutamate receptor mRNA editing in the brain, we have made two strains of mice with mutations at amino acid 636, the Q/R-editing site in GluR5, using embryonic stem cell-mediated transgenesis. GluR5(RloxP/RloxP) mice encode an arginine at the Q/R site of the GluR5 subunit, whereas GluR5(wt(loxP)/wt(loxP)) mice encode a glutamine at this site, similar to wild-type mice. Mutant animals do not exhibit developmental abnormalities, nor do they show deficits in the behavioral paradigms tested in this study. Kainate receptor current densities were reduced by a factor of six in acutely isolated sensory neurons of dorsal root ganglia from GluR5(RloxP/RloxP) mice compared with neurons from wild-type mice. However, the editing mutant mice did not exhibit altered responses to thermal and chemical pain stimuli. Our investigations with the GluR5-editing mutant mice have therefore defined a set of physiological processes in which editing of the GluR5 subunit is unlikely to play an important role.
Treatment of Retinitis Induced by Cytomegalovirus Using Intravitreal Fomivirsen (ISIS 2922) (2020)

Cytomegaloviruses (CMV) are ubiquitous, highly species-specific herpes viruses (Alford and Britt, 1985). As with other herpes viruses, primary CMV infection is often followed by persistent and/or recurrent infections. The molecular biology of the virus and the infectious cycle are well characterized. The infectious cycle is divided into immediate-early, early, and late phases, relative to the time of appearance of CMV-specific proteins and sensitivity to different pharmacological agents (Stinski et al., 1981). The immediate-early period is usually defined as up to 2-4 hours post-infection, and is characterized by the production of a number of proteins responsible for regulation of viral gene expression (Hermiston et al., 1987). These proteins are encoded by the major immediate-early transcriptional unit of the virus, and are required, along with the viral DNA polymerase, for viral replication (Heilbronn et al., 1987).
Endoscopic biliary stenting: indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline – Updated October 2017 (2018)

ESGE recommends against routine preoperative biliary drainage in patients with malignant extrahepatic biliary obstruction; preoperative biliary drainage should be reserved for patients with cholangitis, severe symptomatic jaundice (e. g., intense pruritus), or delayed surgery, or for before neoadjuvant chemotherapy in jaundiced patients. Strong recommendation, moderate quality evidence. ESGE recommends the endoscopic placement of a 10-mm diameter self-expandable metal stent (SEMS) for preoperative biliary drainage of malignant extrahepatic biliary obstruction. Strong recommendation, moderate quality evidence.ESGE recommends SEMS insertion for palliative drainage of of extrahepatic malignant biliary obstruction. Strong recommendation, high quality evidence. ESGE recommends against the insertion of uncovered SEMS for the drainage of extrahepatic biliary obstruction of unconfirmed etiology. Strong recommendation, low quality evidence. ESGE suggests against routine preoperative biliary drainage in patients with malignant hilar obstruction. Weak recommendation, low quality evidence.ESGE recommends uncovered SEMSs for palliative drainage of malignant hilar obstruction. Strong recommendation, moderate quality evidence.ESGE recommends temporary insertion of multiple plastic stents or of a fully covered SEMS for treatment of benign biliary strictures. Strong recommendation, moderate quality evidence.ESGE recommends endoscopic placement of plastic stent(s) to treat bile duct leaks that are not due to transection of the common bile duct or common hepatic duct. Strong recommendation, moderate quality evidence.
Thermal and Structural Response of Pin Fins for Different Interface Conditions (2010)

Thermal management of electronic products relies on the effective dissipation of heat. Heat sink elements (e.g. a pin fin) are used for any effective heat dissipation network. Despite much optimized design of the heat sink element, the heat transfer may not be effective because the interface between power device and heat sink element is critical in the heat dissipation network. Thermal Interface Materials TIM (e.g. adhesive, solder, pads, or pastes) are employed at interface between power device and heat sink element to minimize the interface thermal resistance. However, several challenges need to be addressed before they can be successfully utilized because depending on the thermal interface conditions, the thermal stress level can attain undesirable values. This issue can be addressed by the optimization of the system design with the help of simulation methods. Generally the effects of interface conditions are studied on the thermal performance of the heat sink system whereas in this paper, a coupled-field (thermal-structural) analysis using FEM is performed to study the thermal as well as structural behavior of the heat sink system. Temperature variation and stress fields in the region of interface between pin fin and base plate are analyzed. Effects of various parameters (such as contact pressure, surface roughness, TIM thickness, and operating conditions) on the resulting thermal and structural response at the interface are presented. It has been found that different interface conditions may have comparable thermal performance with significant different stress fields at the interface. Therefore stress state must be known to ensure the structural integrity of the heat sink system for a given operating condition.
Supplementary Table 8 from Multilevel Whole-Genome Analysis Reveals Candidate Biomarkers in Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;PDF file - 34K, Significantly expressed proteins encoded by genes in regions that are cytogenetically associated with copy-number aberrations in aberrant versus diploid tumors&lt;/p&gt;
Adalimumab induction therapy improves health-related quality of life in patients with moderately to severely active ulcerative colitis. (2011)

PURPOSE: Patients who experienced disease exacerbation on either active or placebo maintenance therapy in PRECiSE 2 (NCT00152425) were re-induced with certolizumab pegol (CZP).The purpose of this study was to evaluate the long-term (4-year) sustainability of remission (total Harvey-Bradshaw index [HBI] score of less than or equal to 4 points) and safety of CZP in anti-TNF-naı ¨ve vs -non-naı ¨ve patients who were in remission at Week 4 of PRECiSE 4 (NCT00160706).METHODS: In PRECiSE 2, patients (n¼428) who responded to induction therapy with CZP at Week 6 were randomized to continuous therapy with CZP or placebo (drug interruption) during Weeks 6-26.Patients who had an exacerbation of symptoms before Week 26 could enter PRECiSE 4, an open-label extension study.In PRECiSE 4, patients received CZP 400 mg at Weeks 0, 2, and 4 followed by every-4-week (q4w) maintenance therapy with CZP 400 mg through Week 208 (4 years).Thus, patients receiving active treatment were given 1 single extra dose, and then continued with q4w maintenance therapy in PRECiSE 4. Disease activity was measured using the HBI.RESULTS: A total of 124 patients entered PRECiSE 4 from PRECiSE 2: 49 who had been randomized to CZP and 75 who had been randomized to placebo.Among these patients, 84 were anti-TNF naı ¨ve and 40 were non-naı ¨ve.By Week 4, 38% (47/124) achieved HBI remission (intent-to-treat [ITT]).After 1, 2, 3, and 4 years of q4w CZP 400 mg maintenance therapy in naı ¨ve vs non-naı ¨ve patients, remission was maintained in 68% vs 47%, 71% vs 64%, 60% vs 70%, and 63% vs 50% patients, respectively (observed case).In general, rates of remission were similar in the naı ¨ve vs non-naı ¨ve pts.No new safety concerns were identified.CONCLUSIONS: CZP 400 mg re-induction successfully recaptured and maintained remission in patients with disease exacerbation who were naı ¨ve to anti-TNF treatment.These data suggest that a long-term benefit is achieved with CZP 400 mg q4w with no dose escalation in anti-TNF-naı ¨ve patients who lost response due to drug interruption or lost initial response to active therapy.
Free-Radical Telomerization of Tetrafluoroethylene in Supercritical Carbon Dioxide (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleFree-Radical Telomerization of Tetrafluoroethylene in Supercritical Carbon DioxideT. J. Romack, J. R. Combes, and J. M. DeSimoneCite this: Macromolecules 1995, 28, 5, 1724–1726Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ma00109a057https://doi.org/10.1021/ma00109a057research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
National multidisciplinary tumor board (MTB): Report of the first 526 questions raised within RYTHMIC, the network for thymic malignancies in France. (2014)

7605 Background: RYTHMIC (Réseau tumeurs THYMiques et Cancer) is a nationwide network for thymic malignancies, which was funded in 2012 by the French National Cancer Institute. The objectives of the network include a territorial coverage by regional expert centers, elaboration of recommendations, dissemination of knowledge and promotion of collaborative research. All patients diagnosed with thymic malignancy in France have to be discussed on a real-time basis at a reference web-based national MTB or regional MTB. Patient’s data from the MTB were prospectively entered in a database. Methods: We report the patient’s and tumor’s characteristics and treatment modalities of the patients included during the first 2 years of MTB. Questions raised during the MTB were reviewed. Results: From January to December 2013, 383 patients were included in the RYTHMIC database. There were 197 (51%) men and 186 (49%) women. Among 304 cases, histology was thymoma for 198 (65%) patients (16 (5%) type A, 31 (10%) type AB, 38 (12%) type B1, 46 (15%) type B2, 35 (12%) type B3, 38 (12%) mixed type, 4 unknown), and thymic carcinoma for 34 (11%) patients, 7 (2%) carcinoïds; other histologies were diagnosed for 65 (21%) patients. Among 206 cases, Masaoka-Koga stage was I, IIA, IIB, III, IVA, and IVB in 46 (22%), 33 (16%), 28 (13%), 37 (18%), 44 (21%), and 18 (9%) patients, respectively. 71 (18%) patients presented with autoimmune disorder, consisting of myasthenia gravis in 60% of the cases. Surgery was performed for 229 patients, mostly using a median sternotomy approach (52% of cases), video-assisted surgery accounted for 9% of the cases. Among the 526 questions addressed during the MTB, the most frequent were the indication of post-operative radiotherapy (29%), recurrence management (18%) and indication of surgery of a mediastinal lesion (17%). Conclusions: The RYTHMIC prospective cohort demonstrates the feasibility of a national MTB for thymic malignancies. It provides with a comprehensive tool to monitor dedicated actions to improve the management of patients in the future, increase the quality-of-care (mostly regarding locoregional treatment), and screen patients for future clinical trials.
Supplementary Appendix S1 from RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across <i>FGFR2</i> Alterations and Resistance Mutations (2023)

&lt;p&gt;ReFocus entry criteria&lt;/p&gt;
A Cryo-CMOS Low-Power Semi-Autonomous Transmon Qubit State Controller in 14-nm FinFET Technology (2022)

A scalable, non-multiplexed cryogenic 14-nm FinFET quantum bit (qubit) state controller (QSC) for use in the semi-autonomous control of superconducting transmon qubits is reported. The QSC includes an augmented general-purpose digital processor that supports waveform generation and phase rotation operations combined with a low-power current-mode single sideband upconversion <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${I}/{Q}$ </tex-math></inline-formula> mixer-based RF arbitrary waveform generator (AWG). Implemented in the 14-nm CMOS FinFET technology, the QSC generates control signals in its target 4.5–5.5-GHz-frequency range, achieving an spurious free dynamic range (SFDR) > 50 dB for a signal bandwidth of 500 MHz. With the controller operating in the 4 K stage of a cryostat and connected to a transmon qubit in the cryostat’s millikelvin stage, measured transmon <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T_{1}$ </tex-math></inline-formula> and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T_{2}$ </tex-math></inline-formula> coherence times were 75.7 and 73 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{s}$ </tex-math></inline-formula> , respectively, in each case comparable to results achieved using conventional room temperature (RT) controls. In further tests with transmons, a qubit-limited error rate of 7.76 × 10−4 per Clifford gate is achieved, again comparable to the results achieved using RT controls. The QSC’s maximum RF output power is −18 dBm, and power dissipation per qubit under active control is 23 mW.
RNA Processing and the Control of Spermatogenesis (1999)

The testis is a rich source for expression of mechanisms for gene regulation. Germ cell expansion and differentiation require many cellular changes and regulatory steps. In the developing germ cells, the length of mRNA transcripts often vary as the cells mature, reflecting the ongoing regulatory changes. Due to the numerous maturation stages that germ cells must undergo, novel gene regulation strategies have been developed that provide for flexible gene expression and protein function. Some of the methods employed in the testis to alter gene expression and function include the initiation of transcription at alternative start sites, the splicing in or out exons to alter the properties of the resulting protein, changes in the site of polyadenylation to control mRNA stability, and delays in the translation of transcripts to ensure a source of protein late in germ cell development after transcription ceases. Using these varied expression strategies, individual genes are able to perform different functions that can be directed to specific development timepoints.
Test Structures and Techniques for On-Wafer CMOS TRL Calibration (2001)

In this paper, we demonstrate for the first time a TRL calibration kit fabricated in CMOS technology. To fulfill a basic requirement of high probe-isolation of the TRL method, we have based all fabricated calibration standards on a shield-based measuring fixture that heavily reduces the effects of the semiconducting substrate. We analyze the electrical performance of the standards, including their accuracy, and the performance of CMOS-based TRL calibration is compared to a reference calibration based on the LRRM technique and a high-precision impedance standard substrate. We find that CMOS TRL calibration is indeed feasible for measurements in the low-gigahertz frequency range but not without implementation problems. I.
Step-Growth Polymerization of Terephthaldehyde Catalyzed by N-Heterocyclic Carbenes (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTStep-Growth Polymerization of Terephthaldehyde Catalyzed by N-Heterocyclic CarbenesJulien Pinaud, Kari Vijayakrishna, Daniel Taton*, and Yves Gnanou*View Author Information Laboratoire de Chimie des Polymères Organiques, Université Bordeaux 1 - CNRS - ENSCPB, 16 Avenue Pey-Berland, 33607 Pessac Cedex, France*Corresponding authors. E-mail: [email protected] (D.T.); [email protected] (Y.G.).Cite this: Macromolecules 2009, 42, 14, 4932–4936Publication Date (Web):June 24, 2009Publication History Received26 April 2009Revised16 June 2009Published online24 June 2009Published inissue 28 July 2009https://pubs.acs.org/doi/10.1021/ma900907fhttps://doi.org/10.1021/ma900907frapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1690Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Gel permeation chromatography,Monomers,Polymerization,Polymers,Solvents Get e-Alerts
Manipulating magnetoelectric energy landscape in multiferroics (2020)

Magnetoelectric coupling at room temperature in multiferroic materials, such as BiFeO<sub>3</sub>, is one of the leading candidates to develop low-power spintronics and emerging memory technologies. Although extensive research activity has been devoted recently to exploring the physical properties, especially focusing on ferroelectricity and antiferromagnetism in chemically modified BiFeO<sub>3</sub>, a concrete understanding of the magnetoelectric coupling is yet to be fulfilled. We have discovered that La substitutions at the Bi-site lead to a progressive increase in the degeneracy of the potential energy landscape of the BiFeO<sub>3</sub> system exemplified by a rotation of the polar axis away from the 〈111〉<sub>pc</sub> towards the 〈112〉<sub>pc</sub> discretion. This is accompanied by corresponding rotation of the antiferromagnetic axis as well, thus maintaining the right-handed vectorial relationship between ferroelectric polarization, antiferromagnetic vector and the Dzyaloshinskii-Moriya vector. As a consequence, La-BiFeO<sub>3</sub> films exhibit a magnetoelectric coupling that is distinctly different from the undoped BiFeO<sub>3</sub> films.