gebhart/patrepeval huggingface dataset:
An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma (2012)

Prognostic/epidemiologic study, level III; diagnostic study, level IV.
Wireless Factory Automation: Radio Channel Evolution in Repeated Manufacturing Processes (2016)

Wireless technologies have to be enhanced to meet the latency and reliability requirements of mission-critical machine–type communication (MTC) in automation systems. Investigating the characteristics of radio channels in typical factory environments is fundamental when designing the wireless industrial Internet of the future. In this paper, we provide results of an indoor channel measurement campaign in a representative factory automation lab. The measurements were performed at a carrier frequency of 2.25 GHz. We focus on communication between industrial robots and their controller entities over short distances. Our use case is a pick-and-place process with repetitions. We allow other active machinery and moving personnel nearby the automation cell. Based on the power delay profile and the corresponding power spectral density, we analyze the time evolution of channel snapshots on fixed spatial positions in repeated processes. Furthermore, we study the correlation of successive channel profiles along the process trajectory. By obtaining high channel correlation over time, we show that scattering and reflection effects from active and moving obstacles surrounding the manufacturing area are limited. Our findings allow a channel-aware planning of wireless control loops by optimized link adaption in wireless systems.
Soft decision-directed map estimate of fast rayleigh flat fading channels (2003)

An iterative receiver with soft-decision feedback is derived by using the expectation-maximization algorithm for maximum a posteriori estimate of fast Rayleigh flat fading channels. Simulation results indicate that in a fast fading environment, the derived receiver can perform better than an iterative receiver with hard-decision feedback.
Granulocyte Depletion Prevents Tumor Necrosis Factor-mediated Acute Lung Injury in Guinea Pigs (1988)

To examine the role of polymorphonuclear neutrophils (PMN) and other granulocytes in the pathogenesis of acute lung injury caused by tumor necrosis factor alpha (TNF), we compared the permeability edema and pulmonary histopathology in normal (granulocyte sufficient) guinea pigs and in granulocytopenic guinea pigs treated with TNF. Circulating granulocytes were depleted with cyclophosphamide. Two groups of normal animals were treated with either saline (PMN+/Control) or 1.4 x 10(6) U/kg recombinant human TNF (PMN+/TNF). Three granulocytopenic groups were treated with either saline (PMN-/Control), TNF (PMN-/TNF), or intravenous infusion of 2 x 10(9) E. coli strain J96 (PMN-/Sepsis). We measured the amount of 125I-labeled albumin in bronchoalveolar lavage (BAL) fluid and whole lung tissue and the wet/dry lung weight ratio to assess pulmonary transvascular protein flux and edema. We also quantified PMN in BAL fluid and fixed lung tissue. There were no statistically significant differences in any of these parameters between the PMN+/Control, PMN-/Control, or PMN-/TNF groups, except that the PMN+/Control predictably had more PMN/alveolus than the PMN- groups. However, both the PMN+/TNF and the PMN-/Sepsis groups had increased amounts of 125I-labeled albumin in BAL fluid and lung tissue (p less than 0.01) and increased wet/dry lung weight ratios (p less than 0.05), compared to all other groups. Histopathologically, capillary congestion and moderate inflammation were seen in the PMN+/TNF group, and acute inflammation and gross alveolar hemorrhage were seen in the PMN-/Sepsis group.(ABSTRACT TRUNCATED AT 250 WORDS)
A Ku-Band Interference-Rejection CMOS Low-Noise Amplifier Using Current-Reused Stacked Common-Gate Topology (2007)

A Ku-band CMOS low-noise amplifier (LNA) with high interference-rejection (IR), wide gain control range, and low dc power consumption is presented. The LNA consists of two common-gate metal-oxide-semiconductor field-effect transistors interconnected with an interstage parallel tank for the IR. The stacked common-gate stages share the same dc bias current to reduce power consumption and have controllable gain by changing this dc current. The implemented 0.13 mum CMOS LNA achieves measured power gain of 10.8 dB, noise figure of 4.2 dB, output P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> dB of -4.3 dBm at 15 GHz, while rejecting interference down to a 38.5 dB level. The gain control range is 23.3 dB by varying the gate voltage from 0.2 to 1.2 V. The LNA consumes only 4 mA from a 1.3-V supply.
New Applications for Polymer Overlays (2015)

Polymer concrete (PC) overlays have proven to be a very effective method of extending the lives of bridge decks and improving skid resistance. Many states in the U.S have specifications and have used overlays on hundreds of bridge decks. Multiple-layer epoxy, epoxy and methacrylate slurry, and polyester premixed overlays have been widely used. One of the keys to successful performance is surface preparation. The very light weight, water tightness, good skid resistance, excellent bond to concrete, and excellent durability have made PC overlays a very sustainable solution for increasing the life of bridges and parking garages, But in recent years very thin overlays referred to as high-friction surface treatments (HFST) have been widely used to provide skid resistance for asphalt pavements in high accident zones, particularly on horizontal curves. Several state departments of transportation (DOTs) have reported very significant reductions in accidents after HFST have been applied. The total length of the application is often only a few hundred meters or less. The cost, when compared to other remedial measures, has been very competitive. The treatments are very similar to very thin slurry overlays. The purpose is not to structurally rehabilitate the pavement, but to provide increased skid resistance for safety. There is also an increased use of thin overlays to provide color for applications including pedestrian and bicycle lanes, bus lanes, entrance and exit ramps, cross walks, and rail road crossings. There are few standards in the U.S. for colors in various applications or for where color should be used. But these thin overlays provide high visibility, skid resistance, and long life. A discussion of these applications, materials and installation methods, and where available, costs, will be presented.
Toward Sustainable Multifunctional Coatings Containing Nanocellulose in a Hybrid Glass Matrix (2018)

We report on a sustainable route to protective nanocomposite coatings, where one of the components, nanocellulose fibrils, is derived from trees and the glass matrix is an inexpensive sol-gel organic-inorganic hybrid of zirconium alkoxide and an epoxy-functionalized silane. The hydrophilic nature of the colloidal nanocellulose fibrils is exploited to obtain a homogeneous one-pot suspension of the nanocellulose in the aqueous sol-gel matrix precursors solution. The mixture is then sprayed to form nanocomposite coatings of a well-dispersed, random in-plane nanocellulose fibril network in a continuous organic-inorganic glass matrix phase. The nanocellulose incorporation in the sol-gel matrix resulted in nanostructured composites with marked effects on salient coating properties including optical transmittance, hardness, fracture energy, and water contact angle. The particular role of the nanocellulose fibrils on coating fracture properties, important for coating reliability, was analyzed and discussed in terms of fibril morphology, molecular matrix, and nanocellulose/matrix interactions.
SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection (2013)

Four of the five members of the Toll/IL-1R domain-containing adaptor family are required for signaling downstream of TLRs, promoting innate immune responses against different pathogens. However, the role of the fifth member of this family, sterile α and Toll/IL-1R domain-containing 1 (SARM), is unclear. SARM is expressed primarily in the CNS where it is required for axonal death. Studies in Caenorhabditis elegans have also shown a role for SARM in innate immunity. To clarify the role of mammalian SARM in innate immunity, we infected SARM(-/-) mice with a number of bacterial and viral pathogens. SARM(-/-) mice show normal responses to Listeria monocytogenes, Mycobacterium tuberculosis, and influenza virus, but show dramatic protection from death after CNS infection with vesicular stomatitis virus. Protection correlates with reduced CNS injury and cytokine production by nonhematopoietic cells, suggesting that SARM is a positive regulator of cytokine production. Neurons and microglia are the predominant source of cytokines in vivo, supporting a role for SARM as a link between neuronal injury and innate immunity.
Strain Imaging of Nanoscale Semiconductor Heterostructures with X-Ray Bragg Projection Ptychography (2014)

We report the imaging of nanoscale distributions of lattice strain and rotation in complementary components of lithographically engineered epitaxial thin film semiconductor heterostructures using synchrotron x-ray Bragg projection ptychography (BPP). We introduce a new analysis method that enables lattice rotation and out-of-plane strain to be determined independently from a single BPP phase reconstruction, and we apply it to two laterally adjacent, multiaxially stressed materials in a prototype channel device. These results quantitatively agree with mechanical modeling and demonstrate the ability of BPP to map out-of-plane lattice dilatation, a parameter critical to the performance of electronic materials.
Novel genetic changes in Autosomal dominant, ACTH independent nacronodular adrenal hyperplasia associated with hypercortisolism and giant adrenals (2016)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Expanding the toolbox of metabolically stable lipid prodrug strategies (2023)

Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy. While the literature provides a practical prodrug playbook to facilitate the delivery of nucleoside and nucleotide therapeutics, small context-dependent amendments to these popular prodrug strategies can drive dramatic improvements in pharmacokinetic (PK) profiles. Herein we offer a brief overview of current prodrug strategies, as well as a case study involving the fine-tuning of lipid prodrugs of acyclic nucleoside phosphonate tenofovir (TFV), an approved nucleotide HIV reverse transcriptase inhibitor (NtRTI) and the cornerstone of combination antiretroviral therapy (cART). Installation of novel lipid terminal motifs significantly reduced fatty acid hepatic ω-oxidation while maintaining potent antiviral activity. This work contributes important insights to the expanding repertoire of lipid prodrug strategies in general, but particularly for the delivery and distribution of acyclic nucleoside phosphonates.
Constraints on collective density variables: Two dimensions (2004)

Collective density variables $\ensuremath{\rho}(\mathbit{k})$ have proved to be useful tools in the study of many-body problems in a variety of fields that are concerned with structural and kinematic phenomena. In spite of their broad applicability, mathematical understanding of collective density variables remains an underexplored subject. In this paper, we examine features associated with collective density variables in two dimensions using numerical exploration techniques to generate particle patterns in the classical ground state. Particle pair interactions are governed by a continuous, bounded potential. Our approach involves constraining related collective parameters $C(\mathbit{k})$, with wave vector $\mathbit{k}$ magnitudes at or below a chosen cutoff, to their absolute minimum values. Density fluctuations for those $\mathbit{k}$'s thus are suppressed. The resulting investigation distinguishes three structural regimes as the number of constrained wave vectors is increased---disordered, wavy crystalline, and crystalline regimes---each with characteristic distinguishing features. It should be noted that our choice of pair potential can lead to pair correlation functions that exhibit an effective hard core and thus signal the formation of a hard-disk-like equilibrium fluid. In addition, our method creates particle patterns that are hyperuniform, thus supporting the notion that structural glasses can be hyperuniform as the temperature $T\ensuremath{\rightarrow}0$.
ChemInform Abstract: Two Novel Resveratrol Trimers from Dipterocarpus grandiflorus (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mixed-granular architectural diversity for device security in the Internet of Things (2017)

The following topics are dealt with: cryptography; field programmable gate arrays; system-on-chip; random number generation; microprocessor chips; security of data; integrated circuit design; computational complexity; low-power electronics; and oscillators.
Techno-Economic Analysis of Integrated Gasification Fuel Cell Systems (2020)

This is a presentation that was delivered virtually at the 2020 International Pittsburgh Coal Conference. In the presentation, details of the cost and performance parameter improvement due to incremental changes made in gasification and fuel cell operation and system configurations were presented.&#160;High level results indicate that SOFC fueled by coal-derived synthesis gas can be competitive with other fossil-based energy generation technologies when significant improvement to gasification technology is made and carbon capture is included.&#160;The cost of carbon capture of this system is very low due to the high efficiency of the SOFC and the high system fuel utilization due to the vent gas recirculation concept which recirculates hydrogen in the effluent back to the cell.
Comparison study between single and differential miniature UWB antenna (2014)

A comparison study between single and differential - UWB - antenna approach for body area network (BAN) applications is proposed in this paper. For compactness reasons, the antennas are studied in order to be integrated on a chip packaging (QFN64 package). In addition, a special attention has been given to design antennas with main polarization normal to the human head. Two antennas structure has been developed taking into account these strong requirements. These antennas provide broadband characteristics and omnidirectional radiation patterns over the whole 7-9 GHz frequency band. Antennas performances obtained by simulation and measurement are compared in order to open a discussion on the advantages and drawbacks of each structure.
Developmental language learning impairments (2002)

Developmental language learning impairments (LLI) are one of the most prevalent of all developmental disabilities, can occur in children for a wide variety of reasons, and have been shown to co-occur frequently with other developmental social, emotional and behavioral disorders, as well as with academic achievement problems. Research pertaining to developmental LLI of unknown origin, with an emphasis on the continuum between oral and written language impairment, is the focus of this review. Given the complexity of language learning, research has focused on multiple levels of analysis, including linguistic, neuropsychological, genetic, neurobiological, and remediation studies. To date, the vast majority of data on LLI derive from studies focused on a single level of analysis. Although attempts have been made to integrate data across studies and multiple levels of analysis, this has proven to be problematic, given the heterogeneity of the subject populations used to study LLI, as well as the differences in ages, degree of impairment, and types of impairment included in each study. Given that LLI is a complex developmental disability, it is suggested that future research would benefit from taking a multiple levels of analysis approach with the same individuals, incorporating mathematical models designed to analyze dynamically changing complex systems, and studying individual differences in language learning, prospectively and longitudinally, throughout the most dynamic stages of the process.
Measurement of the photorefractive grating phase shift in a polymer by an ac phase-modulation technique (1998)

The complex coupling constant of a photorefractive polymer was measured as a function of an applied electric field by use of a modified ac phase modulation technique. We determined that both a photorefractive index grating and a nonphotorefractive absorption grating were present. The electric field dependencies of the amplitude and the phase of the photorefractive gain coefficient were accurately described by standard photorefractive theory. The accuracy of the photorefractive phase shift as measured by this phase-modulation technique was ±1° near phase shifts of 90° and ±3° near phase shifts of 45°.
Dose-escalation trial of milatuzumab (humanized anti-CD74 monoclonal antibody) in multiple myeloma (2009)

8593 Background: CD74 (HLA-DR-associated invariant chain) is highly expressed in multiple myeloma (MM), rapidly internalized, and a promising target for immunotherapy. Methods: A multicenter dose-escalation study was initiated in patients (pts) with relapsed/refractory MM who had failed at least 2 standard therapies. Pts received milatuzumab IV twice-weekly for 4 wks, with doses escalated by a 3+3 cohort design. Pts were evaluated over 12 wks, with responding pts continuing follow-up. AEs and safety laboratories were evaluated by NCI CTC v3 grades, with any treatment-related Grade 3–4 events considered dose-limiting toxicity (DLT). Responses were classified by EBMT criteria, with PK and immunogenicity evaluated by serum milatuzumab levels and human anti-milatuzumab antibody (HAHA) titers, respectively. Results: Twenty-one pts (12M/9F, median age 63) have now received 1.5 (n=8), 4.0 (n=9) or 8.0 mg/kg (n=4) doses twice weekly. They had MM for 0.9–16.8 years (median 5.4), predominantly IgG subtype, were heavily pretreated (4 median prior treatments), and were Durie-Salmon stage II (n=13) or III (n=8). After increasing premedications and slowing administration, infusions were well tolerated (Grade 1–2). There was 1 DLT (infusion reaction) and 3 SAEs (bact. meningitis, confusion/hypercalcemia, fever post demerol) at 1.5 mg/kg, 1 DLT (unexplained anemia) and 2 SAEs (cord compression, epistaxis/thrombocytopenia), at 4.0 mg/kg, but no DLTs or SAEs at 8.0 mg/kg. There has been no pattern of other AEs nor effects on routine laboratories, including serum chemistries, CBC, serum immunoglobulins, B- or T-cells, and no cases of HAHA. At current doses, milatuzumab is rapidly cleared from serum, with little accumulation and low trough levels across infusions. There have been no objective responses so far, but 4 pts have had stable disease by EBMT criteria for at least 3 months post-treatment, occurring with a possible trend towards higher milatuzumab serum levels than pts with earlier disease progression. Conclusions: Milatuzumab doses up to 8.0 mg/kg may be given safely twice-weekly for 4 weeks. In spite of rapid clearance, several patients have had disease stabilization at 4.0 and 8.0 mg/kg doses, which is encouraging. Accrual of the next cohort receiving 16.0 mg/kg is ongoing. [Table: see text]
Activity Detection in Distributed Massive MIMO With Pilot-Hopping and Activity Correlation (2022)

Many real-world scenarios for massive machine-type communication involve sensors monitoring a physical phenomenon. As a consequence, the activity pattern of these sensors will be correlated. In this letter, we study how the correlation of user activities can be exploited to improve detection performance in grant-free random access systems where the users transmit pilot-hopping sequences and the detection is performed based on the received energy. We show that we can expect considerable performance gains by adding regularizers, which take the activity correlation into account, to the non-negative least squares, which has been shown to work well for independent user activity.
Rate-Splitting for Multi-User Multi-Antenna Wireless Information and Power Transfer (2019)

In a multi-user multi-antenna Simultaneous Wireless Information and Power Transfer (SWIPT) network, the transmitter sends information to the Information Receivers (IRs) and energy to Energy Receivers (ERs) concurrently. A conventional approach is based on Multi-User Linear Precoding (MU-LP) where each IR directly decodes the intended stream by fully treating the interference from other IRs and ERs as noise. In this paper, we investigate the application of linearly-precoded Rate-Splitting (RS) in Multiple Input Single Output (MISO) SWIPT Broadcast Channel (BC). By splitting the messages of IRs into private and common parts and encoding the common parts into a common stream decoded by all IRs, RS manages the interference dynamically. The precoders are designed such that the Weighted Sum Rate (WSR) of IRs is maximized under the total transmit power constraint and the sum energy constraint for ERs. Numerical results show that the proposed RS-assisted strategy provides a better rate-energy tradeoff in MISO SWIPT BC. Under a sum energy constraint of ERs, RS-assisted strategy achieves better WSR performance of IRs than MU-LP and NOMA in a wide range of IR and ER deployments. Hence, we draw the conclusion that RS is superior for downlink SWIPT networks.
Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes (2020)

Nucleic acid-based therapeutics, including the use of messenger RNA (mRNA) as a drug molecule, has tremendous potential in the treatment of chronic diseases, such as age-related neurodegenerative diseases. In this study, we have developed a cationic liposomal formulation of mRNA and evaluated the potential of intranasal delivery to the brain in murine model. Preliminary <i>in vitro</i> studies in J774A.1 murine macrophages showed GFP expression up to 24 h and stably expressed GFP protein in the cytosol. Upon intranasal administration of GFP-mRNA/cationic liposomes (3 mg/kg dose) in mice, there was significantly higher GFP-mRNA expression in the brain post 24 h as compared to either naked mRNA or the vehicle-treated group. Luciferase mRNA encapsulated in cationic liposomes was used for quantification of mRNA expression distribution in the brain. The results showed increased luciferase activity in the whole brain in a dose-dependent manner. Specifically, the luciferase-mRNA/cationic liposome group (3 mg/kg dose) showed significantly higher luciferase activity in the cortex, striatum, and midbrain regions as compared with the control groups, with minimal systemic exposure. Overall, the results of this study demonstrate the feasibility of brain-specific, nonviral mRNA delivery for the treatment of various neurological disorders.