gebhart/patrepeval huggingface dataset:
Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein (2018)

Abstract Accurate chromosome segregation during meiosis relies on the prior establishment of at least one crossover recombination event between homologous chromosomes, which is often associated with the meiosis-specific MutSγ complex. The recombination intermediates that give rise to MutSγ interhomolog crossovers are embedded within a hallmark meiotic prophase structure called the synaptonemal complex (SC), but the mechanisms that coordinate the processes of SC assembly (synapsis) and crossover recombination remain poorly understood. Among known central region building blocks of the budding yeast SC, the Zip1 protein is unique for its SC-independent role in promoting MutSγ crossovers. Here we report that adjacent regions within Zip1’s unstructured N terminus encompass its crossover and SC assembly functions. We previously showed that deletion of Zip1 residues 21-163 abolishes tripartite SC assembly and prevents the robust SUMOylation of the SC central element component, Ecm11, but allows excess MutSγ crossover recombination. We find the reciprocal phenotype when Zip1 residues 2-9 or 10-14 are deleted; in these mutants SC assembles and Ecm11 is hyperSUMOylated, but MutSγ crossovers are strongly diminished. Interestingly, Zip1 residues 2-9 or 2-14 are required for the normal localization of Zip3, a putative E3 SUMO ligase and pro-MutSγ crossover factor, to Zip1 polycomplex structures and to recombination initiation sites. By contrast, deletion of Zip1 residues 15-20 does not detectably prevent Zip3’s localization at Zip1 polycomplex and supports some MutSγ crossing over but prevents normal SC assembly and robust Ecm11 SUMOylation. These results highlight distinct N terminal regions that are differentially critical for Zip1’s roles in crossover recombination and SC assembly; we speculate that the adjacency of these regions enables Zip1 to serve as a liaison, facilitating crosstalk between the two processes by bringing crossover recombination and synapsis factors in close proximity to one another.
Development of Nucleic Acid Drugs for Neurological Disorders (2012)

Novel therapeutic strategies using nucleic acid drugs, such as plasmid DNA (pDNA) and nuclear factor-κB (NFκB) decoy, have been sought for non-treatable neurological disorders. Among them, the application of pDNA has been extensively studied in diabetic neuropathy. Since growth factors, such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), have both neurotrophic and angiogenic properties, intramuscular injection of pDNA encoding these genes has been examined and shown to be effective for treatment in experimental animals and also in clinical trials. These growth factors have also been shown to accelerate neuroprotection, angiogenesis, and regeneration in the brain, and overexpression of these factors showed therapeutic effects in cerebral ischemia in rodents. Inhibition of inflammation is another strategy to treat cerebrovascular diseases. Recent studies suggest that NFκB plays critical roles in the formation of cerebral aneurysms, and inhibition of its function by NFκB decoy was shown to prevent cerebral aneurysm enlargement through inhibition of NFκB-mediated inflammation. In the field of neurodegenerative disease, the potential of pDNA as a tool for vaccination has attracted researchers since pDNA itself has shown adjuvant properties and the potential to induce immunity or immune tolerance. pDNA encoding disease antigens, such as amyloid-Aβ in Alzheimer disease or myelin basic protein in multiple sclerosis (MS), was shown to have therapeutic effects in rodents, and its efficacy and safety were reported in a phase I/II clinical study in MS. In this review, we discuss the potential and problems of nucleic acid drugs in neurological disorders.
Predictors of prostate cancer-specific anxiety following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer. (2019)

64 Background: Prostate Cancer (PCa) related anxiety varies widely based on management option. SBRT offers a safe and effective treatment for localized PCa. However, there is a paucity of data regarding PCa specific anxiety following SBRT and its relationship with PSA kinetics. In this report we present the results of a mail-in survey conducted amongst the participants of our prospective institutional quality of life (QOL) trial and identify sociodemographic and disease specific predictors of anxiety. Methods: Patients with localized PCa treated with SBRT at a single institution from 2007-2018 were eligible for inclusion in this study. The Memorial Anxiety Scale for PCa (MAX-PC) survey, was mailed to 450 patients on July of 2018. Patient’s total MAX-PC score (scale 0-54) was recorded. A score of ≥ 27 was defined as significant anxiety. Disease specific as well as demographic features were analyzed for possible correlation with self-reported anxiety. Results: By August 31, 2018, 227 patients had responded to the survey . The median score at all time points was 5 (1-41). Stratified by risk grouping; Low, Intermediate, and High Risk patients’ median scores were 7, 4.5 and 6. Six patients had a MAX-PC score≥27. Patients who were at least 2 years out from SBRT treatment had lower mean MAX-PC scores than those who were still within 2 years (6.3 versus 8.1, p = 0.045). Stratified by age, patients &gt; 80 years old had a median score of 2 versus those &lt; 70 with a median score of 6. Caucasian patients had lower mean MAX-PC scores than non-Caucasian patients (6.6 versus 9.1, p = 0.021). Patients who had at least a 0.5 ng/mL increase in PSA in their last 3 measurements had higher mean MAX-PC scores than those who did not (13.0 versus 7.0, p = 0.040). Conclusions: Patients with clinically localized PCa treated with SBRT experience minimal PCa specific anxiety. Anxiety surrounding PCa decreases with time. Non-Caucasian patients tended to have more anxiety than Caucasian patients. Patients who had recent PSA bounces tend to have higher levels of anxiety about their disease. Further follow-up of these patients over time would aid in assessing the progression of PCa specific anxiety as their lives progress.
A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. (1994)

Overexpression of the beta-amyloid precursor protein gene (beta-APP) may contribute to the abnormal generation of beta-amyloid protein in Alzheimer's disease. We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter. A beta-APP promoter-luciferase reporter gene is transcriptionally activated by PMA, as well as by expression of constitutively activated PKC or by expression of c-Jun. Further characterization suggests that the distal but not the proximal AP-1 recognition site binds nuclear proteins regulated by PKC, and that the AP-1 binding activity is likely to be composed of Jun-Jun homodimers rather than Jun-Fos heterodimers. Additional studies demonstrate that a single copy of the distal AP-1 site fused to a heterologous promoter is sufficient to confer a response to PMA. Mutagenesis of this site in the beta-APP promoter renders it unresponsive to c-Jun and attenuates transcriptional activation by PMA. We suggest that cellular mediators that activate PKC, particularly those that induce significant increases in c-Jun, may up-regulate expression of the beta-APP gene and consequently affect production and processing of this protein.
Phase II Study of a HER-2/neu (HER2) Intracellular Domain (ICD) Peptide-Based Vaccine Administered to Stage IIIB and IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab Monotherapy (2008)

Abstract : The primary purpose of this grant is to determine the overall survival (OS) benefit in Stage IIIB and IV HER2 positive breast cancer patients vaccinated with a HER2 intracellular domain (ICD) peptide-based vaccine while receiving maintenance trastuzumab. Patients enrolled will be HER2 overexpressing stage IIIB and IV breast cancer patients who have been treated to a clinical complete response remission or have stable bone only disease and are within 6 months of starting maintenance trastuzumab. The scope of the work includes a Phase II, nonrandomized, single arm study of a HER2 ICD peptide-based vaccine given concurrently with trastuzumab. Ten subjects have been enrolled during the last reporting period. All adverse events reported for these ten subjects are grades 1 and 2. There have been no major findings to date.
Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated byStreptococcus suisserotype 2 (2003)

Streptococcus suis serotype 2 is a world-wide agent of diseases among pigs including meningitis, septicemia and arthritis. This microorganism is also recognized as an important zoonotic agent. The pathogenesis of the meningitis caused by S. suis is poorly understood. We have previously shown that S. suis is able to adhere to human brain microvascular endothelial cells (BMEC), but not to human umbilical vein endothelial cells (HUVEC). The objective of this work was to study the ability of S. suis serotype 2 to induce the release of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1); IL-6 and the chemokines IL-8 and monocyte chemotactic protein-1 (MCP-1) by human BMEC and HUVEC, using a sandwich enzyme-linked immunosorbent assay. S. suis was able to stimulate the production of IL-6, IL-8 and MCP-1 by BMEC but not HUVEC, in a time- and concentration-dependent manner. Bacterial cell wall components were largely responsible for such stimulation. The human and pig origin of strains does not seem to affect the intensity of the response; indeed, a very heterogeneous pattern of cytokine and chemokine production was observed for the different strains tested in this study. In situ production of cytokines and chemokines by BMEC may be the result of specific adhesion of S. suis to this cell type, with several consequences such as increased recruitment of leukocytes and an increase in the blood-brain barrier permeability.
Controllable synthesis of a chemically stable molecular sieving nanofilm for highly efficient organic solvent nanofiltration (2020)

A chemically stable molecular sieving nanofilm with Janus pore structure was synthesized with high permeability in both polar and non-polar solvent.
ChemInform Abstract: Cross Coupling Reactions of 2‐(Allyloxy(thio))benzothiazoles with Organocopper Reagents in Dihydropyranoid Systems. Mechanistic Implications of the Substrate and the Reagent: Regio‐ and Stereocontrolled Access to Branched‐Chain Sugars. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide (2002)

The plasma levels of both bosentan and glyburide were reduced after concomitant administration. This finding is consistent with a CYP3A4-inducing potential of both drugs. The observed pharmacodynamic interaction between bosentan and glyburide in patients with chronic heart failure cannot be explained by a pharmacokinetic interaction.
A scalable process for manufacturing integrated, washable smart garments applied to heart rate monitoring (2017)

We present a new method for building wearable electronic and sensor systems in which all components are permanently integrated directly into garments in high volume except for the battery. We discuss the design and construction of the first such fully-integrated sensor system, wearable heart rate monitoring garments (a sports bra, a compression short, and a compression shirt) that are machine washable. We demonstrate that heart rate measurements can be detected by our system's fabric-based electrodes. We also show experimental results from wash testing of the garment. The process described herein can be applied to the construction of computational and sensor systems for healthcare, sports, virtual reality, and first responder and military personnel monitoring, among others.
Patellofemoral joint: identification of abnormalities with active-movement, "unloaded" versus "loaded" kinematic MR imaging techniques. (1993)

A positioning device was used to apply a "load" to stress the patellofemoral joint during active-movement, kinematic magnetic resonance (MR) imaging. Twenty-three symptomatic patellofemoral joints were studied by using "unloaded" versus "loaded" techniques. With the unloaded technique, seven joints were normal, nine had lateral subluxation, three had lateral tilt, and four had medial subluxation. With the loaded technique, one was normal, 13 had lateral subluxation, four had lateral tilt, and five had medial subluxation. The active-movement, loaded kinematic MR imaging technique provides improved ability to identify patellofemoral joint abnormalities.
Polyoxygenated Marine Steroids from the Deep Water Starfish Styracaster caroli (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyoxygenated Marine Steroids from the Deep Water Starfish Styracaster caroliMaria Iorizzi, Francesco de Riccardis, Luigi Minale, Elio Palagiano, Raffaele Riccio, Cécile Debitus, and Daniel DuhetCite this: J. Nat. Prod. 1994, 57, 10, 1361–1373Publication Date (Print):October 1, 1994Publication History Published online1 July 2004Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/np50112a005https://doi.org/10.1021/np50112a005research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
C12(γ,p)11B cross section from 80 to 157 MeV (1995)

The $^{12}\mathrm{C}$(\ensuremath{\gamma},p${)}^{11}$B differential cross section has been measured over proton angles ranging from 58\ifmmode^\circ\else\textdegree\fi{} to 128\ifmmode^\circ\else\textdegree\fi{}, using tagged photons of energy 80--157 MeV, for low-lying regions of residual excitation energy in $^{11}\mathrm{B}$. The data have been compared with four different types of calculation. It is shown that scaling of the cross section with momentum mismatch occurs for both the ground-state and excited-state data.
Characterization of the Effect of Renal Impairment on Upadacitinib Pharmacokinetics (2019)

Upadacitinib is a novel selective Janus kinase 1 inhibitor developed for treatment of rheumatoid arthritis and other autoimmune diseases. The objective of this study was to assess the pharmacokinetics and safety of a single upadacitinib dose in subjects with normal renal function and in subjects with renal impairment. A total of 24 subjects between the ages of 18 and 75 years were assigned to 1 of 4 renal function groups based on estimated glomerular filtration rate (normal, mild, moderate, severe; N = 6/group). A single 15-mg dose of upadacitinib extended-release formulation was administered under fasting conditions. Serial plasma and urine samples were assayed to evaluate the effect of renal impairment on upadacitinib exposure through regression analysis and analysis of covariance. The primary analysis was the regression analysis of upadacitinib exposures versus estimated glomerular filtration rate. The point estimates for upadacitinib plasma exposure ratios (90% confidence interval [CI]) in subjects with mild, moderate, and severe renal impairment were 1.18 (90%CI, 1.06-1.32), 1.33 (90%CI, 1.11-1.59), and 1.44 (90%CI, 1.14-1.82) for area under the plasma concentration-time curve and 1.06 (90%CI, 0.92-1.23), 1.11 (90%CI, 0.88-1.40), and 1.14 (90%CI, 0.84-1.56) for maximum observed plasma concentration, respectively, relative to subjects with normal renal function based on the regression analysis. The analysis of covariance categorical analysis provided consistent results. Upadacitinib was well tolerated by all subjects, and no safety issues were identified in subjects with renal impairment. Renal impairment has a limited effect on upadacitinib pharmacokinetics. This is in agreement with the known limited role of urinary excretion in upadacitinib elimination. Based on the limited impact on exposure, no dose adjustment is necessary for upadacitinib in subjects with impaired renal function.
High-capacity transmission with homogeneous multi-core fibers and wideband optical comb sources (2018)

We describe a number of experiments demonstrating and exploring the potential of combing wideband-optical comb sources with space-division multiplexed transmission systems and in particular with homogeneous-single-mode multicore fibers including Pb/s transmission using conventional receiver technology without MIMO processing and longdistance recirculating transmission. We describe experiments using synchronized parallel transmission loops to investigate joint processing of spatial super channels and multi-dimensional modulation before discussing how optical comb technology may combine with SDM fibers to allow comb re-generation across networks to enable high-order modulation with simplified DSP. Overall, these experiments demonstrate a range of scenarios where the combination of optical combs and homogeneous MCFs can be advantageous in future optical communications networks.
Abstract 3675: Farnesyltransferase inhibitor (FTI) disruption of Rheb/FKBP38 association leads to FKBP38-mediated inactivation of mTOR (2010)

Abstract The activation of the Rheb (Ras homologue enriched in brain) / mTOR (mammalian target of rapamycin) pathway plays a central role in integrating growth factor, nutrient and energy signals and regulates cell growth (cell mass and size) and proliferation (cell number). Recently Rheb was found to activate mTOR by binding and antagonizing its endogenous inhibitor, FKBP38. However, it is not known whether inhibition of Rheb farnesylation by farnesyltransferase Inhibitors (FTIs) is sufficient to disrupt Rheb/FKBP38 interaction and leads to inactivation of mTOR. Here we demonstrate that FTI-2153 disrupts Rheb binding to FKBP38 allowing FKBP38 to bind and to inactivate mTOR. Furthermore, in human cancer cells, FTI-2153 also blocks IGF-1-stimulated Rheb/FKBP38 binding and promotes mTOR/FKBP38 binding. We further show that FTI-2153 inhibits Rheb-mediated activation of mTOR to phosphorylate S6 kinase, and that a geranylgeranylated mutant variant of Rheb that is as efficient as wild-type farnesylated Rheb at activating mTOR rescues cancer cells from FTI-induced inactivation of mTOR signaling, inhibition of anchorage-dependent and -independent tumor cell growth and induction of apoptosis. These results demonstrate that FTI-mediated disruption of the Rheb/FKBP38 interaction leads to inactivation of mTOR and is an effective approach to inhibiting tumor proliferation and survival and that inhibition of Rheb farnesylation mediates, at least in part, the anti-tumor effects of FTIs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3675.
Vibrational overlap integrals between the neutral and ion states of NH/sub 3/ and ND/sub 3/: application to the vibrational dependence of the NH/sub 3/+(v2) + NH/sub 3/(0) symmetric charge transfer reaction. Interim report (1987)

Vibrational overlap integrals were calculated for the transition between the neutral ground state and the ion state of ammonia and ND/sub 3/ for the vibrational bending mode. Calculations were performed by numerically solving the Schroedinger equation. The vibrational overlap integrals were used to simulate the dependence of the cross section for the symmetric charge-transfer reaction on the initial vibrational quantum state of the ion. The cross sections show a gradual increase with the vibrational bending mode in agreement with experiment.
Graft subsidence after instrument-assisted anterior cervical fusion (2002)

The length of a fusion segment decreases in the immediate weeks following instrument-assisted ACF. Construct length is the most important determinant of subsidence. When designing multilevel cervical constructs, consideration of the effects of graft subsidence may help to avoid hardware-related complications.
Magnetic Metamaterial Superlens for Increased Range Wireless Power Transfer (2014)

The ability to wirelessly power electrical devices is becoming of greater urgency as a component of energy conservation and sustainability efforts. Due to health and safety concerns, most wireless power transfer (WPT) schemes utilize very low frequency, quasi-static, magnetic fields; power transfer occurs via magneto-inductive (MI) coupling between conducting loops serving as transmitter and receiver. At the "long range" regime - referring to distances larger than the diameter of the largest loop - WPT efficiency in free space falls off as (1/d)(6); power loss quickly approaches 100% and limits practical implementations of WPT to relatively tight distances between power source and device. A "superlens", however, can concentrate the magnetic near fields of a source. Here, we demonstrate the impact of a magnetic metamaterial (MM) superlens on long-range near-field WPT, quantitatively confirming in simulation and measurement at 13-16 MHz the conditions under which the superlens can enhance power transfer efficiency compared to the lens-less free-space system.
Towards a literature of the unword : a study of the aesthetic quest of Samuel Beckett. (1974)

Dept. of English Language, Literature, and Creative Writing. Paper copy at Leddy Library: Theses &amp; Major Papers - Basement, West Bldg. / Call Number: Thesis1973 .S62. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.A.)--University of Windsor (Canada), 1974.
Fluxonium Qubits in a Flip-Chip Package (2023)

The strong anharmonicity and high coherence times inherent to fluxonium superconducting circuits are beneficial for quantum information processing. In addition to requiring high-quality physical qubits, a quantum processor needs to be assembled in a manner that minimizes crosstalk and decoherence. In this paper, we report work on fluxonium qubits packaged in a flip-chip architecture, where a classical control and readout chip is bump-bonded to the quantum chip, forming a multi-chip module (MCM). The modular approach allows for improved connectivity between the qubits and control/readout elements, and separate fabrication processes. We characterize the coherence properties of the individual fluxonium qubits, demonstrate high fidelity single-qubit gates with 6 ns microwave pulses (without DRAG), and identify the main decoherence mechanisms to improve on the reported results.