gebhart/patrepeval huggingface dataset:
Effect of Si Concentration of a Brazing Precursor on the Bonding Strength of Aluminum Foam Bonded via Foaming Bonding (2021)

Pure Al foams were bonded via foaming bonding using Al–10.5Si brazing alloy. However, the pores around the bonded area were coarsened because Si diffused into the Al foam from the brazing foam, where it reduced the melting temperature, leading to melting of the cell walls of the Al foam. The bonding strength of the bonded foam varied greatly. An Al–Si brazing precursor with a low Si concentration was prepared and used for foaming bonding of two Al foam specimens. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy were used to investigate the bonding state. Four-point bending tests were conducted to evaluate the bonding strength. The brazing foam was metallurgically bonded with the Al foam when brazing precursors with 9.4–10.5 mass% Si were used. The bonding interfaces were partially observed by SEM. The bonding strength of the Al foam bonded using 10.5 mass% Si brazing foam was lower than the minimum strength of the Al foam. The bonding strength of the specimen bonded using the 9.4 mass% Si brazing foam was lower than the minimum strength of pure Al foam and the bonding strength of the other bonded specimens. An Al–Si brazing precursor with an appropriate Si concentration prevents pore coarsening around the bonding interface. The bonding strength became low when the Si concentration in the Al–Si brazing precursor was excessively low.
Ciprofloxacin resistance in the faecal carriage of patients undergoing transrectal ultrasound guided prostate biopsy (2013)

Antimicrobial resistance to ciprofloxacin in the rectal flora was common, particularly in patients with recent ciprofloxacin use and a heart valve replacement. Despite a significant correlation between those patients who developed infections and the detection of ciprofloxacin-resistant organisms, only 9.0% (n = 15) of the total group with ciprofloxacin resistance developed an infectious complication. Future studies will need to evaluate the cost effectiveness and clinical utility of a pre-biopsy rectal culture in targeting antibiotic prophylaxis.
Enhanced Data Transfer for Multi-Loaded Source Synchronous Signal Groups (2018)

Enhanced performance of memory channels directly correlates to increased system performance. This paper presents an alternative opportunity to regain lost performance on high-capacity low-cost DDR channels. A novel way of modifying synchronous timing of DDR signal groups is presented. Signal integrity metrics with simulation data are also demonstrated.
Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome (2013)

Activation of the NLRP3 inflammasome by diverse stimuli requires a priming signal from TLRs and an activation signal from purinergic receptors or pore-forming toxins. In this study, we demonstrate, through detailed analysis of NLRP3 activation in macrophages deficient in key downstream TLR signaling molecules, that MyD88 is required for an immediate early phase, whereas Toll/IL-1R domain-containing adapter inducing IFN-β is required for a subsequent intermediate phase of posttranslational NLRP3 activation. Both IL-1R-associated kinase (IRAK) 1 and IRAK4 are critical for rapid activation of NLRP3 through the MyD88 pathway, but only IRAK1 is partially required in the Toll/IL-1R domain-containing adapter inducing IFN-β pathway. IRAK1 and IRAK4 are also required for rapid activation of NLRP3 by Listeria monocytogenes, as deletion of IRAK1 or IRAK4 led to defective inflammasome activation. These findings define the pathways that lead to rapid NLRP3 activation and identify IRAK1 as a critical mediator of a transcription-independent,inflammasome-dependent early warning response to pathogenic infection.
Herbal-T, enabling integration, interoperability, and reusability of Internet components (1999)

Herbal-T introduces an architecture where Internet component integration, interoperability, and component instantiation are the base for information flow coordination. This architecture introduces a framework for combining object functionality across the Internet to create new Internet applications. These new applications are defined in terms of active relationships. The concept of active relations as found in active databases is extended to define a new paradigm for creating Internet applications. In addition, Internet component interoperability is achieved using Applets, Java Applications, CORBA and RMI. This paper presents how the Herbal-T architecture support extends active relations to create an integration, interoperability, and reusability framework.
BIOMECHANICAL CONSIDERATIONS IN THE DESIGN OF GRAFT: THE HOMEOSTASIS HYPOTHESIS (2006)

Since its inception in the 1960s, coronary artery bypass graft (CABG) evolved as one of the most common, best documented, and most effective of all major surgical treatments for ischemic heart disease. Despite its widespread use, however, the outcome is not always completely satisfactory. The objective of this review is to highlight the physical determinants of biomechanical design of CABG so that future procedures would have prolonged patency and better outcome. Our central axiom postulates the existence of a mechanical homeostatic state of the blood vessel, i.e., the variation in vessel wall stresses and strains are relatively small under physiological conditions. Any perturbation of mechanical homeostasis leads to growth and remodeling. In this sense, stenosis and failure of a graft may be viewed as an adaptation process gone awry. We outline the principles of engineering design and discuss the biofluid and biosolid mechanics principles that may have the greatest bearing on mechanical homeostasis and the long-term outcome of CABG.
Supplementary Movie S2 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer (2023)

&lt;p&gt;Effect of scrambled MFF peptide on tumor cell morphology&lt;/p&gt;
Data Supplement from p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8<sup>+</sup> T-cell Responses (2023)

&lt;p&gt;Supplementary Figure 1. Frequency of myeloid derived suppressor cells in the peripheral blood in patients pre and post vaccination with p53MVA&lt;/p&gt;
Selective Reduction of Aromatic Azides in Solution/Solid‐Phase and Resin Cleavage by Employing BF3×OEt2/EtSH. Preparation of DC‐81. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Introduction of Frequency-Domain Signal Processing to Broadband Single-Carrier Transmissions in a Wireless Channel (2009)

Recently, frequency-domain equalization (FDE) has been attracting much attention as a way to improve single-carrier (SC) signal transmission in a frequency-selective wireless channel. Since the SC signal spectrum is spread over the entire signal bandwidth, FDE can take advantage of channel frequency-selectivity and achieve the frequency diversity gain. SC with FDE is a promising wireless signal transmission technique. In this article, we review the pioneering research done on SC with FDE. The principles of simple one-tap FDE, channel estimation, and residual inter-symbol interference (ISI) cancellation are presented. Multi-input/multi-output (MIMO) is an important technique to improve the transmission performance. Some of the studies on MIMO/SC with FDE are introduced.
A high S/N ratio and high full well capacity CMOS image sensor with active pixel readout feedback operation (2007)

We discuss results of the design and operations of a CMOS image sensor with high S/N ratio while keeping wide dynamic range. Readout gains and input-referred noises of the image sensor are improved by actively using a pixel source follower feedback operation. A 1/4-inch 5.6 mum times 5.6 mum pixel VGA color CMOS image sensor with a lateral overflow integration capacitor in pixel in a 0.18 mum 2P3M CMOS process achieves about 1.7 times the gain compared with the case where the feedback operation is not positively used, resulting in a high input-referred conversion gain exceeded 200 muV/e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> , a low input-referred noise below 2 e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> without column amplifier and a high full well capacity of about 1.3 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> .
Solution Structure of the 30 kDa Polysulfide-Sulfur Transferase Homodimer from Wolinella succinogenes, (2004)

The periplasmic polysulfide-sulfur transferase (Sud) protein encoded by Wolinella succinogenes is involved in oxidative phosphorylation with polysulfide-sulfur as a terminal electron acceptor. The polysulfide-sulfur is covalently bound to the catalytic Cys residue of the Sud protein and transferred to the active site of the membranous polysulfide reductase. The solution structure of the homodimeric Sud protein has been determined using heteronuclear multidimensional NMR techniques. The structure is based on NOE-derived distance restraints, backbone hydrogen bonds, and torsion angle restraints as well as residual dipolar coupling restraints for a refinement of the relative orientation of the monomer units. The monomer structure consists of a five-stranded parallel beta-sheet enclosing a hydrophobic core, a two-stranded antiparallel beta-sheet, and six alpha-helices. The dimer fold is stabilized by hydrophobic residues and ion pairs found in the contact area between the two monomers. Similar to rhodanese enzymes, Sud catalyzes the transfer of the polysulfide-sulfur to the artificial acceptor cyanide. Despite their similar functions and active sites, the amino acid sequences and structures of these proteins are quite different.
Importance of the Donor:Fullerene Intermolecular Arrangement for High-Efficiency Organic Photovoltaics (2014)

The performance of organic photovoltaic (OPV) material systems are hypothesized to depend strongly on the intermolecular arrangements at the donor:fullerene interfaces. A review of some of the most efficient polymers utilized in polymer:fullerene PV devices, combined with an analysis of reported polymer donor materials wherein the same conjugated backbone was used with varying alkyl substituents, supports this hypothesis. Specifically, the literature shows that higher-performing donor-acceptor type polymers generally have acceptor moieties that are sterically accessible for interactions with the fullerene derivative, whereas the corresponding donor moieties tend to have branched alkyl substituents that sterically hinder interactions with the fullerene. To further explore the idea that the most beneficial polymer:fullerene arrangement involves the fullerene docking with the acceptor moiety, a family of benzo[1,2-b:4,5-b']dithiophene-thieno[3,4-c]pyrrole-4,6-dione polymers (PBDTTPD derivatives) was synthesized and tested in a variety of PV device types with vastly different aggregation states of the polymer. In agreement with our hypothesis, the PBDTTPD derivative with a more sterically accessible acceptor moiety and a more sterically hindered donor moiety shows the highest performance in bulk-heterojunction, bilayer, and low-polymer concentration PV devices where fullerene derivatives serve as the electron-accepting materials. Furthermore, external quantum efficiency measurements of the charge-transfer state and solid-state two-dimensional (2D) (13)C{(1)H} heteronuclear correlation (HETCOR) NMR analyses support that a specific polymer:fullerene arrangement is present for the highest performing PBDTTPD derivative, in which the fullerene is in closer proximity to the acceptor moiety of the polymer. This work demonstrates that the polymer:fullerene arrangement and resulting intermolecular interactions may be key factors in determining the performance of OPV material systems.
Composition measurements and imagery of nanoparticle gas loading experiments as an investigation of LENR reactions (2013)

A key issue for the development of a LENR power unit concerns the changes in nanoparticles during runs. LENUCO LLC is working on such power units and this work on nanoparticle changes is being done in support of that effort. [1] Our experiments have used pressurization of various different nanoparticle alloys with either deuterium or hydrogen. [2] The principal elements in the nanoparticle alloys are Nickel, Palladium and Zirconium with different percentage compositions [2]. We will present the results obtained from study of surface aspects and composition changes in the nanoparticles following runs by two techniques, SEM and SIMS, respectively. The results reported here are from various run times including an extended run that accumulated 40 hours run time. Until now, both techniques have revealed some important facts. The SEM technique has pointed out a significant average increase in the nanoparticle surface roughness, depending on run time. We also have seen an agglomeration of the particles, mainly in the deuterium pressurized Palladium Zirconium alloys. Possible explanations for the agglomeration will be discussed, including both physical and magnetic phenomena.
The pancreatic cancer microenvironment: A true double agent (2017)

The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.
Biotransformation of Green Tea Polyphenols and the Biological Activities of Those Metabolites (2007)

Green tea ( Camellia sinensis, Theaceae) and its major polyphenol constituents, the catechins, have been reported to have many health benefits including the prevention of cancer and heart disease. Many mechanisms of action have been proposed based on in vitro models; however, the importance of most of these mechanisms remains to be determined in vivo. The bioavailability and biotransformation of tea catechins play a key role in determining the importance of various mechanisms in vivo. Likewise, the biological activity and bioavailability of tea catechin metabolites, an understudied area, are important in understanding the potential beneficial effects of tea. In this article, we review the data available on the biotransformation of the tea catechins and the limited data set available on the biological activities of the catechin metabolites. Careful interpretation of available data, carefully designed animal experiments, and integration of bioavailability and biological activity data are needed if the disease preventive activity of tea is to be understood. We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites.
Supplementary Figure 4 from Targeting the Oligomerization Domain of ETO Interferes with RUNX1/ETO Oncogenic Activity in t(8;21)-Positive Leukemic Cells (2023)

Supplementary Figure 4 from Targeting the Oligomerization Domain of ETO Interferes with RUNX1/ETO Oncogenic Activity in t(8;21)-Positive Leukemic Cells
Transgene-derived hepatocyte growth factor attenuates reactive renal fibrosis in aristolochic acid nephrotoxicity (2003)

Circulating transgene-derived HGF (2-10 ng/ml) could not prevent tubular degeneration caused by AA, but attenuated interstitial fibrogenesis during tubular regeneration. These findings suggest a possible therapeutic efficacy for renal interstitial fibrosis following tubular degeneration even of low-dose HGF.
ChemInform Abstract: Borsche Cinnoline Synthesis (2012)

Abstract Review: 56 refs.
Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models (2008)

Antitumor activity and overall survival of mice bearing highly aggressive tumors are significantly improved by codelivery of oncolytic adenoviruses and hyaluronidase when compared with either of the monotherapy-treated groups, and it may prove to be a potent and novel approach to treating patients with cancer.
Plant peroxidase gene expression and function (1992)

Conference Article| May 01 1992 Plant peroxidase gene expression and function P. E. Kolattukudy; P. E. Kolattukudy 1Ohio State Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Royce Mohan; Royce Mohan *Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar M. Aslam Bajar; M. Aslam Bajar 1Ohio State Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Bruce A. Sherf Bruce A. Sherf 1Ohio State Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (2): 333–337. https://doi.org/10.1042/bst0200333 Article history Received: December 18 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation P. E. Kolattukudy, Royce Mohan, M. Aslam Bajar, Bruce A. Sherf; Plant peroxidase gene expression and function. Biochem Soc Trans 1 May 1992; 20 (2): 333–337. doi: https://doi.org/10.1042/bst0200333 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ABA, abscisic acid, β-GUS, β-glucuronidase, nos, nopaline synthase gene © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
TIR-1 carbon dioxide laser system for fusion (1980)

During recent years pulsed CO(2) lasers for fusion research have been under construction in the I. V. Kurchatov Institute of Atomic Energy and the D. V. Efremov Electro-Physical Apparatus Institute. Efforts are being concentrated at present on two approaches: (1) microsecond laser pulse plasma heating in solenoids and theta pinches (UTRO system) and (2) nanosecond CO(2) laser utilization for inertial confinement fusion. The TIR-1 system was created to develop nanosecond CO(2) laser technology and to study laser-target interaction at 10 microm. This system is designed to deliver ~1-kJ energy in one beam of ~l-nsec duration. The TIR-1 system consists of an oscillator-preamplifier system that produces an ~1-nsec laser pulse with an energy contrast ratio of ~10(6), a large-aperture (30 x 30-cm(2)) triple-pass amplifier capable of providing approximately 1 kJ in a 1-nsec pulse, a target chamber with diagnostic equipment, and associated engineering systems.
Speckle reduction in polarized laser backlight LCDs (2021)

We have developed a 17.3-inch 8K wide color gamut in-plane switching LCD (IPS-LCD) with a polarized laser backlight. By applying a zero–zero-birefringence polymer, the polarized laser backlight emits polarized light with 88% polarization. We adapted the double light guide plate laser backlight to achieve uniform luminance. The developed IPS-LCD achieves a wide color gamut with high efficiency. The speckle problem was solved by applying an AC voltage to the laser diodes. In addition, the double light guide plates effectively suppress the speckle as the light is uniformly mixed in the light guide plate.
Expansion of Secretin-Like G Protein-Coupled Receptors and Their Peptide Ligands via Local Duplications Before and After Two Rounds of Whole-Genome Duplication (2013)

In humans, the secretin-like G protein-coupled receptor (GPCR) family comprises 15 members with 18 corresponding peptide ligand genes. Although members have been identified in a large variety of vertebrate and nonvertebrate species, the origin and relationship of these proteins remain unresolved. To address this issue, we employed large-scale genome comparisons to identify genome fragments with conserved synteny and matched these fragments to linkage groups in reconstructed early gnathostome ancestral chromosomes (GAC). This genome comparison revealed that most receptor and peptide genes were clustered in three GAC linkage groups and suggested that the ancestral forms of five peptide subfamilies (corticotropin-releasing hormone-like, calcitonin-like, parathyroid hormone-like, glucagon-like, and growth hormone-releasing hormone-like) and their cognate receptor families emerged through tandem local gene duplications before two rounds (2R) of whole-genome duplication. These subfamily genes have, then, been amplified by 2R whole-genome duplication, followed by additional local duplications and gene loss prior to the divergence of land vertebrates and teleosts. This study delineates a possible evolutionary scenario for whole secretin-like peptide and receptor family members and may shed light on evolutionary mechanisms for expansion of a gene family with a large number of paralogs.
Binding of alanine‐substituted peptides to the MHC class I protein, Kd (1993)

Peptides eluted from the native MHC class I molecule, Kd, are generally nonamers that display a strong preference for Tyr in position 2. We investigated the molecular basis for this 'consensus motif' by synthesizing a virally derived peptide, NP 147-155, that is known to be presented by Kd on living cells, and peptide variants of NP 147-155 in which the amino acids in the different positions were sequentially replaced by Ala. All of the peptides bound to purified Kd molecules in vitro with high affinity, except for the peptide in which Tyr2 was replaced by Ala, for which the affinity for Kd decreased at least 100-fold. These results confirm the interpretation of the in vivo studies; namely, that Tyr2 is a critical anchor residue for binding to Kd.
Electrical injuries (2007)

Today, human-made and natural sources together kill about 1100 to 1200 people each year in the United States. The number of people injured worldwide by electricity, however, remains unclear, because it is generally underreported and it is common for survivors to avoid medical care initially. Although scientific investigations of electrical injuries date back to 1884, with current scientific knowledge and the clinical appearance of electrical injuries, we now know that the outcomes of electrical injuries differ substantially, depending on whether technical electricity with low-volt household current, high-volt current, or lightning is the underlying cause.