gebhart/patrepeval huggingface dataset:
Seed oil extraction from red prickly pear using hexane and supercritical CO2: assessment of phenolic compound composition, antioxidant and antibacterial activities (2016)

SC-CO<sub>2</sub> extraction of O. stricta seed oil led to extraction of oil with a similar yield to that with hexane extraction, but with higher polyphenol content. The extract containing polyphenols exhibited high antioxidant and antibacterial properties, demonstrating their great potential as feedstock for high-oil quality. © 2016 Society of Chemical Industry.
Corpus Based Reconstruction Of Speech Degraded By Wind Noise (2015)

Publication in the conference proceedings of EUSIPCO, Nice, France, 2015
Adhesive Antimicrobial Peptides Containing 3,4-Dihydroxy-L-Phenylalanine Residues for Direct One-Step Surface Coating (2021)

Bacterial colonization and transmission via surfaces increase the risk of infection. In this study, we design and employ novel adhesive antimicrobial peptides to prevent bacterial contamination of surfaces. Repeats of 3,4-dihydroxy-L-phenylalanine (DOPA) were added to the C-terminus of NKC, a potent synthetic antimicrobial peptide, and the adhesiveness and antibacterial properties of the resulting peptides are evaluated. The peptide is successfully immobilized on polystyrene, titanium, and polydimethylsiloxane surfaces within 10 min in a one-step coating process with no prior surface functionalization. The antibacterial effectiveness of the NKC-DOPA5-coated polystyrene, titanium, and polydimethylsiloxane surfaces is confirmed by complete inhibition of the growth of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus within 2 h. The stability of the peptide coated on the substrate surface is maintained for 84 days, as confirmed by its bactericidal activity. Additionally, the NKC-DOPA5-coated polystyrene, titanium, and polydimethylsiloxane surfaces show no cytotoxicity toward the human keratinocyte cell line HaCaT. The antimicrobial properties of the peptide-coated surfaces are confirmed in a subcutaneous implantation animal model. The adhesive antimicrobial peptide developed in this study exhibits potential as an antimicrobial surface-coating agent for efficiently killing a broad spectrum of bacteria on contact.
A Bioaccumulative Cyclometalated Platinum(II) Complex with Two-Photon-Induced Emission for Live Cell Imaging (2009)

The cyclometalated platinum(II) complex [Pt(L)Cl], where HL is a new cyclometalating ligand 2-phenyl-6-(1H-pyrazol-3-yl)pyridine containing C(phenyl), N(pyridyl), and N(pyrazolyl) donor moieties, was found to possess two-photon-induced luminescent properties. The two-photon-absorption cross section of the complex in N,N-dimethylformamide at room temperature was measured to be 20.8 GM. Upon two-photon excitation at 730 nm from a Ti:sapphire laser, bright-green emission was observed. Besides its two-photon-induced luminescent properties, [Pt(L)Cl] was able to be rapidly accumulated in live HeLa and NIH3T3 cells. The two-photon-induced luminescence of the complex was retained after live cell internalization and can be observed by two-photon confocal microscopy. Its bioaccumulation properties enabled time-lapse imaging of the internalization process of the dye into living cells. Cytotoxicity of [Pt(L)Cl] to both tested cell lines was low, according to MTT assays, even at loadings as high as 20 times the dose concentration for imaging for 6 h.
A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes (2019)

Recent studies have revealed a possible link between the activities of polymorphic arylamine N-acetyltransferases (NATs) and energy metabolism. We used a Nat1/Nat2 double knockout (KO) mouse model to demonstrate that ablation of the two Nat genes is associated with modest, intermittent alterations in respiratory exchange rate. Pyruvate tolerance tests show that double KO mice have attenuated hepatic gluconeogenesis when maintained on a high-fat/high-sucrose diet. Absence of the two Nat genes also leads to an increase in the hepatic concentration of coenzyme A in mice fed a high-fat/high-sucrose diet. Our results suggest a modest involvement of NAT in energy metabolism in mice, which is consistent with the absence of major phenotypic deregulation of energy metabolism in slow human acetylators.
Low latency DASH - more than just spec (2020)

DASH has become one of the widely adopted and contributed streaming formats for internet streaming services. DASH Industry Forum has been the core catalyzer in this with interoperability discussions supported by publicly available Interoperability Guidelines and testing tools. This paper introduces DASH-IF activities and its tools and proposes a demonstration based on the recent study of low latency DASH service support.
EVIDENCE OF APOPTOSIS IN THE CASTRATION-INDUCED ATROPHY OF THE RAT LEVATOR ANI MUSCLE (2001)

Apoptosis or programmed cell death has been previously reported in androgen-responsive tissue such as the prostate. We tested the hypothesis that apoptosis may also represent a component of the castration-induced atrophy of the sexually dimorphic levator ani (LA) muscle of the male rat. Gonadectomy (GDX) induced a severe decrease in the LA muscle wet weight accompanied by important modifications in cytoarchitecture including an increase in myofibrillar interspace and condensed mitochondria. These alterations were almost completely reversed after 7 days of testosterone propionate replacement therapy (GDX + TP). In GDX rats, internucleosomal DNA fragmentation was confirmed by both agarose gel electrophoresis and electron microscopy. DNA fragmentation was no longer detected in GDX + TP rats. In GDX rats, overexpression of the trpm-2/clusterin gene, used as an early marker of apoptosis, further confirmed that an apoptotic response, typical of androgen-responsive tissues, is taking place following androgen withdrawal.
Monoterpene Metabolism. Cloning, Expression, and Characterization of Menthone Reductases from Peppermint (2005)

(-)-Menthone is the predominant monoterpene produced in the essential oil of maturing peppermint (Mentha x piperita) leaves during the filling of epidermal oil glands. This early biosynthetic process is followed by a second, later oil maturation program (approximately coincident with flower initiation) in which the C3-carbonyl of menthone is reduced to yield (-)-(3R)-menthol and (+)-(3S)-neomenthol by two distinct NADPH-dependent ketoreductases. An activity-based in situ screen, by expression in Escherichia coli of 23 putative redox enzymes from an immature peppermint oil gland expressed sequence tag library, was used to isolate a cDNA encoding the latter menthone:(+)-(3S)-neomenthol reductase. Reverse transcription-PCR amplification and RACE were used to acquire the former menthone:(-)-(3R)-menthol reductase directly from mRNA isolated from the oil gland secretory cells of mature leaves. The deduced amino acid sequences of these two reductases share 73% identity, provide no apparent subcellular targeting information, and predict inclusion in the short-chain dehydrogenase/reductase family of enzymes. The menthone:(+)-(3S)-neomenthol reductase cDNA encodes a 35,722-D protein, and the recombinant enzyme yields 94% (+)-(3S)-neomenthol and 6% (-)-(3R)-menthol from (-)-menthone as substrate, and 86% (+)-(3S)-isomenthol and 14% (+)-(3R)-neoisomenthol from (+)-isomenthone as substrate, has a pH optimum of 9.3, and K(m) values of 674 mum, > 1 mm, and 10 mum for menthone, isomenthone, and NADPH, respectively, with a k(cat) of 0.06 s(-1). The recombinant menthone:(-)-(3R)-menthol reductase has a deduced size of 34,070 D and converts (-)-menthone to 95% (-)-(3R)-menthol and 5% (+)-(3S)-neomenthol, and (+)-isomenthone to 87% (+)-(3R)-neoisomenthol and 13% (+)-(3S)-isomenthol, displays optimum activity at neutral pH, and has K(m) values of 3.0 mum, 41 mum, and 0.12 mum for menthone, isomenthone, and NADPH, respectively, with a k(cat) of 0.6 s(-1). The respective activities of these menthone reductases account for all of the menthol isomers found in the essential oil of peppermint. Biotechnological exploitation of these genes could lead to improved production yields of (-)-menthol, the principal and characteristic flavor component of peppermint.
"Mirror image" reverse turns promote .beta.-hairpin formation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"Mirror image" reverse turns promote .beta.-hairpin formationTasir S. Haque, Jennifer C. Little, and Samuel H. GellmanCite this: J. Am. Chem. Soc. 1994, 116, 9, 4105–4106Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ja00088a067https://doi.org/10.1021/ja00088a067research-articleACS PublicationsRequest reuse permissionsArticle Views546Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
EEV: A Large-Scale Dataset for Studying Evoked Expressions from Video (2020)

Videos can evoke a range of affective responses in viewers. The ability to predict evoked affect from a video, before viewers watch the video, can help in content creation and video recommendation. We introduce the Evoked Expressions from Videos (EEV) dataset, a large-scale dataset for studying viewer responses to videos. Each video is annotated at 6 Hz with 15 continuous evoked expression labels, corresponding to the facial expression of viewers who reacted to the video. We use an expression recognition model within our data collection framework to achieve scalability. In total, there are 36.7 million annotations of viewer facial reactions to 23,574 videos (1,700 hours). We use a publicly available video corpus to obtain a diverse set of video content. We establish baseline performance on the EEV dataset using an existing multimodal recurrent model. Transfer learning experiments show an improvement in performance on the LIRIS-ACCEDE video dataset when pre-trained on EEV. We hope that the size and diversity of the EEV dataset will encourage further explorations in video understanding and affective computing. A subset of EEV is released at https://github.com/google-research-datasets/eev.
Voltammetric Determination of Dopamine with the N-Hydroxysuccinimide Modified Carbon Paste Electrode (2001)

An activated carbon paste electrode was modified with the N-Hydroxysuccinimide(NHS) layer and applied to determine the dopamine in the presence of an excess ascorbic acid using square-wave voltammetry. The electrochemical properties of the modified electrode were examined in the solution containing dopamine/ascorbic acid using cyclic voltammetry(CV): the separation between the oxidation peaks of dopamine and ascorbic acid was largely dependent on the pH of the sample solution and became maximum at pH 4.0. Hence, the square-wave voltammetric determination of dopamine was carried out in a pH 4.0, 100mM phosphate buffer saline(PBS) containing 140mM NaCl. The detection limit and response slop were improved from , respectively, upon modification of the electrode surface by NHS.
Media Design and Challenges for Heat-Assisted Magnetic Recording for 2TBPSI and Beyond (2016)

The demand for greater storage capacity is fueled by current explosive usage of social media, cloud computing, and high-definition film and recording businesses.
DS Sentry: an acquisition ASIC for smart, micro-power sensing applications (2011)

Unattended ground monitoring that combines seismic and acoustic information can be a highly valuable tool in intelligence gathering; however there are several prerequisites for this approach to be viable. The first is high sensitivity as well as the ability to discriminate real threats from noise and other spurious signals. By combining ground sensing with acoustic and image monitoring this requirement may be achieved. Moreover, the DS Sentry<sup>®</sup>provides innate spurious signal rejection by the "active-filtering" technique employed as well as embedding some basic statistical analysis. Another primary requirement is spatial and temporal coverage. The ideal is uninterrupted, long-term monitoring of an area. Therefore, sensors should be densely deployed and consume very little power. Furthermore, sensors must be inexpensive and easily deployed to allow dense placements in critical areas. The ADVIS DS Sentry<sup>®</sup>, which is a fully-custom integrated circuit that enables smart, micro-power monitoring of dynamic signals, is the foundation of the proposed system. The core premise behind this technology is the use of an ultra-low power front-end for active monitoring of dynamic signals in conjunction with a highresolution, &Sigma; &Delta;-based analog-to-digital converter, which utilizes a novel noise rejection technique and is only employed when a potential threat has been detected. The DS Sentry® can be integrated with seismic accelerometers and microphones and user-programmed to continuously monitor for signals with specific signatures such as impacts, footsteps, excavation noise, vehicle-induced ground vibrations, or speech, while consuming only microwatts of power. This will enable up to several years of continuous monitoring on a single small battery while concurrently mitigating false threats.
Análisis de MMPs en fluidos orales en el diagnóstico complementario de las enfermedades periodontales (2012)

La periodontitis constituye la infección bacteriana más prevalente a nivel mundial y representa un factor de riesgo para diversas patologías sistémicas. El estado de inflamación y destrucción periodontal se manifiestan a través de la presencia de biomarcadores en el suero y fluidos orales, tales como el fluido gingival crevicular (FGC), saliva y enjuague oral. Enzimas como las metaloproteinasas de matriz (MMP) y mieloperoxidasa, constituyen biomarcadores potenciales para ensayos moleculares complementarios a la clínica de uso en el sillón dental. A continuación se presenta una revisión de la literatura respecto de la aplicación potencial del análisis de metaloproteinasas de matriz extracelular (MMPs) en el diagnóstico complementario de las enfermedades periodontales. Se ha demostrado que los niveles de MMP-9, -13 y particularmente de MMP- 8, se asocian con el grado de inflamación periodontal, y pueden diferenciar entre sujetos sanos, con gingivitis, periodontitis y peri-implantitis, mientras que la mejoría de los parámetros clínicos en respuesta al tratamiento periodontal se asocia con la reducción de la activación y niveles de estas enzimas en FGC, como así también en el suero. Se concluye que la determinación, particularmente de MMP-8 en fluidos orales presenta un elevado potencial como complemento de los métodos clínicos tradicionales para identificar a los pacientes con periodontitis o en riesgo de desarrollar la enfermedad, monitorear fases del tratamiento y mejoría de signos periodontales e incluso evaluar el estado de inflamación sistémica. Periodontal disease is the most common bacterial infection worldwide and it can contribute to enhance the risk for the development of several systemic diseases. The status of periodontal inflammation and destruction can be reflected in biomarker measurement in serum and oral fluids, like gingival crevicular fluid (GCF), saliva and mouth-rinse. Some enzymes, such as matrix metalloproteinases (MMPs) and myeloperoxidase are potential candidates for chair-side point-of-care oral fluid assays. This review is focused on the utility of matrix metalloproteinase (MMP) analysis in oral fluid as a complementary diagnostic method to chronic periodontitis. Levels of MMP-9,-13 and specially of MMP-8, reflect oral inflammatory status and discriminate among healthy, gingivitis, periodontitis and periimplantitis individuals, whereas MMP levels and activation in GCF and serum are in line with the improvement of clinical parameters in response to periodontal treatment. As a conclusion, MMP-8 assessment in GCF could represent a helpful adjunctive method to traditional diagnostics to identify periodontitis or patients at risk to develop the disease, monitor treatment phases, improvement of periodontal signs and even screen the systemic inflammation status.
Diamond Color Center Based FM Microwave Demodulator (2016)

Nitrogen-vacancy centers, atomic-scale luminescent defects in diamond, are used to transduce frequency-modulated microwave signals to intensity-modulated fluorescence. Our work could lead to realization of radio receivers operating in extreme environments, including high temperature and pressure.
BBCA-LEDGER: High Throughput Consensus meets Low Latency (2023)

This paper presents BBCA-LEDGER, a Byzantine log replication technology for partially synchronous networks enabling blocks to be broadcast in parallel, such that each broadcast is finalized independently and instantaneously into an individual slot in the log. Every finalized broadcast is eventually committed to the total ordering, so that all network bandwidth has utility in disseminating blocks. Finalizing log slots in parallel achieves both high throughput and low latency. BBCA-LEDGER is composed of two principal protocols that interweave together, a low-latency/high-throughput happy path, and a high-throughput DAG-based fallback path. The happy path employs a novel primitive called BBCA, a consistent broadcast enforcing unique slot numbering. In steady state, BBCA ensures that a transaction can be committed with low latency, in just 3 network steps. Under network partitions or faults, we harness recent advances in BFT and build a fallback mechanism on a direct acyclic graph (DAG) created by BBCA broadcasts. In this manner, BBCA-LEDGER exhibits the throughput benefits of DAG-based BFT in face of gaps.
Exploration of analog pre-processing architectures for coarse low power motion detection (2011)

In a context of high performance low power integrated vision system design, a methodology based on the exploration of many architectural and algorithmic issues, relying on analog pre-processing of low-resolution images, is considered. In this paper we present the algorithm exploration performed for analog coarse motion detection and the corresponding SystemC model developed for coupling with a digital processing unit simulator.
A Method For Head Related Impulse Response Simplification. (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Simulated Microgravity Impairs Cardiac Autonomic Neurogenesis from Neural Crest Cells (2018)

Microgravity-induced alterations in the autonomic nervous system (ANS) contribute to derangements in both the mechanical and electrophysiological function of the cardiovascular system, leading to severe symptoms in humans following space travel. Because the ANS forms embryonically from neural crest (NC) progenitors, we hypothesized that microgravity can impair NC-derived cardiac structures. Accordingly, we conducted in vitro simulated microgravity experiments employing NC genetic lineage tracing in mice with cKit<sup>CreERT2/+</sup>, Isl1nLacZ, and Wnt1-Cre reporter alleles. Inducible fate mapping in adult mouse hearts and pluripotent stem cells (iPSCs) demonstrated reduced cKit<sup>CreERT2/+</sup>-mediated labeling of both NC-derived cardiomyocytes and autonomic neurons (P < 0.0005 vs. controls). Whole transcriptome analysis, suggested that this effect was associated with repressed cardiac NC- and upregulated mesoderm-related gene expression profiles, coupled with abnormal bone morphogenetic protein (BMP)/transforming growth factor beta (TGF-β) and Wnt/β-catenin signaling. To separate the manifestations of simulated microgravity on NC versus mesodermal-cardiac derivatives, we conducted Isl1nLacZ lineage analyses, which indicated an approximately 3-fold expansion (P < 0.05) in mesoderm-derived Isl-1<sup>+</sup> pacemaker sinoatrial nodal cells; and an approximately 3-fold reduction (P < 0.05) in cardiac NC-derived ANS cells, including sympathetic nerves and Isl-1<sup>+</sup> cardiac ganglia. Finally, NC-specific fate mapping with a Wnt1-Cre reporter iPSC model of murine NC development confirmed that simulated microgravity directly impacted the in vitro development of cardiac NC progenitors and their contribution to the sympathetic and parasympathetic innervation of the iPSC-derived myocardium. Altogether, these findings reveal an important role for gravity in the development of NCs and their postnatal derivatives, and have important therapeutic implications for human space exploration, providing insights into cellular and molecular mechanisms of microgravity-induced cardiomyopathies/channelopathies.
Single-phase inertial factor: laboratory vs. field measurements (2005)

Single-phase inertial factor, β, also known as non-Darcy factor, which is an important flow parameter for determining the productivity of gas wells, is either determined in laboratory or by analysing variable rate well test data. In this study β measurement on a Clashach core sample was conducted in the Laboratory. This β value was then used as an input flow parameter in the in-house finite-element based simulator. The simulator was employed to simulate a variable rate test for an open-hole and a perforated well completion. The results of the generated synthetic data were analysed to obtain the corresponding field β value under different field conditions. The results indicated that for the case of pure radial flow, open-hole, in a homogenous porous medium, β value from field data could be used. However, in the case of presence of any non-uniformity in the flow path, e.g., perforated completion, immobile water, heterogeneity, damage, layering, etc., the calculated β will also reflect these effects and is not necessarily the true representative of real β. The mechanisms of high-velocity flow effect reflected by β value is discussed to explain this difference. Key-words: Inertial factor, Non-Darcy flow, Velocity, Perforated completion, Compressible gas.
Short-term ocular dominance plasticity is not modulated by visual cortex tDCS but increases with length of monocular deprivation (2023)

Transcranial direct current stimulation (tDCS) of the occipital lobe may modulate visual cortex neuroplasticity. We assessed the acute effect of visual cortex anodal (a-)tDCS on ocular dominance plasticity induced by short-term monocular deprivation (MD), a well-established technique for inducing homeostatic plasticity in the visual system. In Experiment 1, active or sham visual cortex tDCS was applied during the last 20 min of 2-h MD following a within-subjects design (n = 17). Ocular dominance was measured using two computerized tests. The magnitude of ocular dominance plasticity was unaffected by a-tDCS. In Experiment 2 (n = 9), we investigated whether a ceiling effect of MD was masking the effect of active tDCS. We replicated Experiment 1 but used only 30 min of MD. The magnitude of ocular dominance plasticity was decreased with the shorter intervention, but there was still no effect of active a-tDCS. Within the constraints of our experimental design and a-tDCS parameters, visual cortex a-tDCS did not modulate the homeostatic mechanisms that drive ocular dominance plasticity in participants with normal binocular vision.