gebhart/patrepeval huggingface dataset:
The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds (2008)

The trypsin-like serine protease marapsin is a member of the large protease gene cluster at human chromosome 16p13.3, which also contains the structurally related proteases testisin, tryptase epsilon, tryptase gamma, and EOS. To gain insight into the biological functions of marapsin, we undertook a detailed gene expression analysis. It showed that marapsin expression was restricted to tissues containing stratified squamous epithelia and was absent or only weakly expressed in all other tissues, including the pancreas. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In the keratinizing stratified squamous epidermis of skin, however, its expression was induced only during epidermal hyperproliferation, such as in psoriasis and in murine wound healing. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. The transient up-regulation of marapsin, which closely correlated with re-epithelialization, was virtually absent in a genetic mouse model of delayed wound closure. These results suggested a function during the process of re-epithelialization. Furthermore, in reconstituted human epidermis, a model system of epidermal differentiation, members of the IL-20 subfamily of cytokines, such as IL-22, induced marapsin expression. Consistent with a physiologic role in marapsin regulation, IL-22 was also strongly expressed in re-epithelializing skin wounds. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.
The International Quotidian Dialysis Registry: Annual report 2008 (2008)

Alternative hemodialysis (HD) schedules, including short-daily and nocturnal HD, continue to proliferate, with the hope of offering improved patient outcomes. Three nights per week and every other night, nocturnal HD are now being provided to more patients worldwide, both at home and in-center. However, alternative HD schedules are still experimental in most centers, and studies establishing the efficacy of these therapies with respect to major clinical outcomes are needed. Endorsed by the National Institutes of Health, the International Quotidian Dialysis Registry is an international collaboration that was established in 2002 to prospectively study large numbers of patients treated with alternate HD schedules. The Registry will ultimately allow alternate HD modalities to be compared to conventional thrice-weekly HD with respect to clinical endpoints, including mortality, using a prospective cohort study. To date, the Registry has enrolled 182, 1193, and 740 subjects from Canada, the United States, and Australia, respectively. This report is the fourth annual update and describes recruitment progress, baseline characteristics of enrolled patients, and worldwide prescription patterns.
ChemInform Abstract: Synthesis of Enantiopure 1‐Azabicyclo[3.2.2]nonanes via Stereoselective Capture of Chiral Carbocations. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multiple model sequential MCMC for jump Markov systems (2014)

The problem of discerning between multiple models arises in several domains and applications. In general the use of models allows an improved and more robust processing of the data, when there is a good match between the model and the data. Consequently correct model selection is essential. New algorithms are thus investigated here which can cope with multiple models. In particular this is shown for the example of tracking of targets presenting sudden maneuver. Particle filter (PF) techniques based on the Interacting Population Markov Chain Monte Carlo (IP-MCMC) scheme present more degrees of freedom in algorithm design with respect to classical Sampling importance resampling (SIR) PF. In this paper two families of IP-MCMC PF algorithms are proposed, respectively Interacting Multiple Models IP-MCMC (IMM-IP-MCMC) and Multiple Model Selection IP Reversible Jump MCMC (MMS-IP-RJMCMC), to tackle the problem of motion model selection for highly maneuverable targets and compared to the Interacting Multiple Models SIR (IMM-SIR) PF implementation. Simulations demonstrate that the proposed algorithms yield a more robust performance than the SIR implementation.
Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection (2017)

In an established animal model of infection, HAV was significantly less susceptible to bacterial colonization and abscess formation than ePTFE. The preclinical findings presented in this manuscript, combined with previously published clinical observations, suggest that bioengineered HAV may exhibit low rates of infection.
Monolithic 3D: an alternative to advanced CMOS scaling, technology perspectives and associated design methodology challenges (2018)

Monolithic 3D technology (M3D) is a promising alternative to takle the loss of Moore's Law scaling beyond 22 nm node. By stacking different circuit layers thanks to nano-scale 3D Monolithic Inter Tier Via (MIV), it will be possible to offer a level of circuit integration never reached before, allowing advanced node scaling again as well as mixing heterogeneous technologies. M3D integrates sequentially different layers of transistors, with an ultra-fine pitch, in the 100 nm range, which is 200x smaller than state-of-the-art Through Silicon Vias (TSV) or 50x smaller than Copper to Copper Hybrid bonding (Cu-Cu HB). This high density 3D integration will pave the way towards new architectures, such as neuro- and bio-inspired applications, ultra-high density computing cube and smarter mixed signal devices within low power constraints. This paper presents an overview of M3D technology and potential applications, and in more detail its associated design challenges, respectively on physical implementation aspects and on thermal dissipation.
A novel high precision temperature sensor (2015)

Presented in this paper is a novel temperature sensor architecture in which we have been able to demonstrate a good temperature measurement accuracy and consistent part to part linearity. This architecture addresses the need for increasingly precise temperature sensors whether stand-alone or embedded within a standard mixed signal process. Also presented is the architectural principle implemented on a standard 0.18μm CMOS process demonstrating better than ±1.5°C accuracy over a -40 to 125°C temperature range without the need of any accurate oil bath calibration.
[Characteristics of the first penicillinase-producing strains of Neisseria gonorrhoeae isolated in Tunisia]. (1991)

The first penicillinase-producing strain of Neisseria gonorrhoeae was recently isolated in Tunisia (1989). Betalactamase production was detected by the iodometric agar test. Minimal inhibitory concentrations (MICs) in agar medium were 128 micrograms/ml for penicillin, ampicillin and amoxycillin. With the amoxycillin-clavulanic acid combination, MIC fell to 0.25 microgram/ml. An Asian-type plasmid pattern was evidenced in this strain, with presence of the 2.6 Mdal cryptic plasmid and of a 4.5 Mdal plasmid.
Student-Centred Pedagogy (2015)

This chapter explores how the ideas around listening to young people emerged and how they evolved by chronicling the research on student perspectives and student-voice in physical education research. It discusses the research on student-centred pedagogy and how this differs from the physical education research on student perspectives and student voice. The chapter highlights how activist scholars have utilized the collective understandings from the research on student voice, student perspectives and student-centred pedagogy in their work with girls as a way of better facilitating girls' active engagement in physical education and physical activity. Activist scholars display an openness to trust girls to be capable and willing to actively participate in a collaborative process designed to help facilitate their engagement in physical education and physical activity. Educational gymnastics and related practices were child-centred in the sense that they focused on the individual rather than the group.
Combined discriminative and generative articulated pose and non-rigid shape estimation (2007)

Estimation of three-dimensional articulated human pose and motion from images is a central problem in computer vision. Much of the previous work has been limited by the use of crude generative models of humans represented as articulated collections of simple parts such as cylinders. Automatic initialization of such models has proved difficult and most approaches assume that the size and shape of the body parts are known a priori. In this paper we propose a method for automatically recovering a detailed parametric model of non-rigid body shape and pose from monocular imagery. Specifically, we represent the body using a parameterized triangulated mesh model that is learned from a database of human range scans. We demonstrate a discriminative method to directly recover the model parameters from monocular images using a mixture of regressors. This predicted pose and shape are used to initialize a generative model for more detailed pose and shape estimation. The resulting approach allows fully automatic pose and shape recovery from monocular and multi-camera imagery. Experimental results show that our method is capable of robustly recovering articulated pose, shape and biometric measurements (e.g. height, weight, etc.) in both calibrated and uncalibrated camera environments. 1
Na(+)-K(+)-ATPase that redistributes to apical membrane during ATP depletion remains functional (1993)

We have previously demonstrated using immunocytochemical, histochemical, and biochemical techniques that ischemia in vivo and ATP depletion in vitro result in dissociation of Na(+)-K(+)-adenosinetriphosphatase (ATPase) from the actin cytoskeleton and redistribution to the apical domain in renal proximal tubule cells. To directly evaluate whether apical Na(+)-K(+)-ATPase retained Na+ pumping activity, a rapidly reversible model of cellular ATP depletion in confluent LLC-PK1 cells grown on semipermeable membranes was utilized. Tight-junction integrity, monitored by electrical resistance, was lost during ATP depletion and reestablished during 2 h of ATP repletion. Total cellular Na(+)-K(+)-ATPase activity and total surface membrane [3H]ouabain binding remained constant, but specific apical [3H]ouabain binding increased (7 vs. 26 fmol/filter, P < 0.01). Apical [3H]ouabain binding returned to baseline during 5 h of ATP repletion. Apically applied ouabain was then used to selectively inhibit apical Na(+)-K(+)-ATPase. It had no effect on apical-to-basolateral Na+ flux under physiological conditions (1.3 +/- 0.61 vs. 1.27 +/- 0.46 meq.filter-1.30 min-1), but it increased the apical-to-basolateral flux in ATP-depleted and then repleted monolayers (0.39 +/- 0.12 vs. 0.83 +/- 0.27 meq.filter-1.30 min-1, P < 0.01), implying that apical Na(+)-K(+)-ATPase retained Na+ pumping activity. Together, these data imply that ATP depletion induces loss of surface membrane polarity resulting in redistribution of functional proteins to the alternate domain.
Improvement of Real-Time Multi-CoreSchedulability with Forced Non-Preemption (2014)

While tasks may be preemptive or non-preemptive (due to their transactional operations), deadline guarantees in multi-core systems have been made only for those task sets in each of which all tasks are preemptive or non-preemptive, not a mixture thereof,i.e., fully preemptive or fully non-preemptive. In this paper, we first develop a schedulability analysis framework that guarantees the timing requirements of a given task set in which a task can be either preemptive or non-preemptive in multi-core systems. We then apply this framework to the prioritization polices of EDF (earliest deadline first) and FP (fixed priority), yielding schedulability tests of mpn-EDF (Mixed Preemptive/Non-preemptive EDF) and mpn-FP, which are generalizations of corresponding fully-preemptive and non-preemptive algorithms, i.e., fp-EDF and np-EDF, and fp-FP and np-FP. In addition to their timing guarantees for any task set that consists of a mixture of preemptive and non-preemptive tasks, the tests outperform the existing schedulability tests of np-EDF andnp-FP (i.e., special cases of mpn-EDF and mpn-FP). Using these tests, we also improve schedulability by developing an algorithm that optimally disallows preemption of a preemptive task under a certain assumption. We demonstrate via simulation that the algorithm finds up to 47.6 percent additional task sets that are schedulable with mpn-FP (likewise mpn-EDF), but not with fp-FP and np-FP (likewisefp-EDF and np-EDF).
Scalable Learning With Thread-Level Parallelism (2022)

A significant increase in the ability to collect and store diverse information over the past decade has led to an outright data explosion, providing larger and richer datasets than ever before. This proliferation in dataset size is accompanied by the dilemma of successfully analyzing this data to discover patterns of interest. Extreme dataset sizes place unprecedented demands on high-performance computing infrastructures, and a gap has developed between the available real-world datasets and our ability to process them; data volumes are quickly approaching Tera and Petabytes. This rate of increase also defies the subsampling paradigm, as even a subsample of data runs well into Gigabytes. To counter this challenge, we exploit advances in multi-threaded processor technology. We explore massive thread-level parallelism – provided by the Cray MTA-2 – as a platform for scalable data mining. We conjecture that such an architecture is well suited for the application of machine learning to large datasets. To this end, we present a thorough complexity analysis and experimental evaluation of a popular decision tree algorithm implemented using fine-grain parallelism, including a comparison to two more conventional architectures. We use diverse datasets with sizes varying in both dimensions (number of records and attributes). Our results lead us to the conclusion that a massively parallel architecture is an appropriate platform for the implementation of highly scalable learning algorithms.
Nondestructive characterization of oxygen-ion-implanted silicon- on-insulator using multiple-angle ellipsometry (1988)

Silicon-on-insulator formed by high-dose and high-energy oxygen ion implantation in silicon, called SIMOX (separation by implanted oxygen), has been characterized nondestructively by multiple-angle ellipsometry using a He–Ne laser at 632.8 nm. A multilayered model exhibiting two interlayers, one between the top silicon layer and the buried oxide layer and the other between the buried oxide and the substrate silicon, offers a simple representation of SIMOX. The difference between low-temperature furnace anneal (1150 °C) and an additional high-temperature rapid thermal anneal (1150+1350 °C) on as-implanted wafers is shown by the better agreement between the theoretical model and the experimental results for the high-temperature annealed SIMOX sample.
Introduction to Tissue Engineering (2014)

In this chapter we introduce the field of tissue engineering and provide a working definition for tissue engineering. We describe seminal publications in the field and look at closely related fields like cell transplantation, regenerative medicine and reparative. We describe the building blocks of tissue engineering, which include cells, biomaterials and bioreactors. We provide an eight step process for tissue and organ fabrication and discuss scientific and technological challenges in the field. We describe the collaborative research for tissue engineering and discuss drivers for growth in the field.
Effect of Endwall Contouring on Performance of Ultra-Low Aspect Ratio Transonic Turbine Inlet Guide Vanes (2007)

In our previous work on ultra-low aspect ratio transonic turbine inlet guide vanes for a small turbofan engine [1], we used numerical stochastic design optimization to propose the new design concept of an extremely aft-loaded airfoil to improve the difficult-to-control aerodynamic loss. At the same time, it is well known that endwall contouring is an effective method for reducing the secondary flow loss. In the literature, both “axisymmetric” and “non-axisymmetric” endwall geometries have been suggested. Almost all of these geometric variations have been based on the expertise of the turbine designer. In our current work, we employed a stochastic optimization method — the evolution strategy (ES) — to optimize and analyze the effect of the axisymmetric endwall contouring on the inlet guide vanes’ performance. In the optimization, the design of the endwall contour was divided into three different approaches: 1) only hub contour, 2) only tip contour, and 3) hub and tip contour together with the possibility to observe the correlation between hub/tip changes with regard to their joint influence on the pressure loss. Furthermore, three dimensional flow mechanisms, related to a secondary flow near the endwall region in the low-aspect ratio transonic turbine IGV, was investigated, based on above optimization results. A design concept and secondary flow characteristics for the low-aspect ratio full annular transonic turbine IGV is discussed in this paper.
Reaction of Ga x As y + clusters with NH 3 (1990)

By using a Fourier transform ion cyclotron resonance (FT ICR) device, semiconductor cluster ions can be observed with extremely high mass resolution (~105), and the surface physics and chemistry can be studied for a wide variety of conditions and reactants.1 Extensive discussion of the design details of this apparatus has appeared elsewhere.2,3
Search for neutral MSSM Higgs bosons decaying into a pair of bottom quarks (2015)

A search for neutral Higgs bosons decaying into a b b quark pair and produced in association with at least one additional b quark is presented. This signature is sensitive to the Higgs sector of the minimal supersymmetric standard model (MSSM) with large values of the parameter tan . The analysis is based on data from proton-proton collisions at a center-of-mass energy of 8 TeV collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 19.7 fb -1 . The results are combined with a previous analysis based on 7 TeV data. No signal is observed. Stringent upper limits on the cross section times branching fraction are derived for Higgs bosons with masses up to 900 GeV, and the results are interpreted within different MSSM benchmark scenarios, m max h , m mod+ h , m mod- h , light-stau and light-stop. Observed 95% confidence level upper limits on tan , ranging from 14 to 50, are obtained in the m mod+ h benchmark scenario.
Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage (2008)

A goal of cartilage tissue engineering is the production of cell-laden constructs possessing sufficient mechanical and biochemical features to enable native tissue function. This study details a systematic characterization of a serum-free (SF) culture methodology employing transient growth factor supplementation to promote robust maturation of tissue-engineered cartilage. Bovine chondrocyte agarose hydrogel constructs were cultured under free-swelling conditions in serum-containing or SF medium supplemented continuously or transiently with varying doses of transforming growth factor beta 3 (TGF-beta3). Constructs were harvested weekly or bi-weekly and assessed for mechanical and biochemical properties. Transient exposure (2 weeks) to low concentrations (2.5-5 ng/mL) of TGF-beta3 in chemically defined medium facilitated robust and highly reproducible construct maturation. Constructs receiving transient TGF-beta3 exposure achieved native tissue levels of compressive modulus (0.8 MPa) and proteoglycan content (6-7% of wet weight) after less than 2 months of in vitro culture. This maturation response was far superior to that observed after continuous growth factor supplementation or transient TGF-beta3 treatment in the presence of serum. These findings represent a significant advance in developing an ex vivo culture methodology to promote production of clinically relevant and mechanically competent tissue-engineered cartilage constructs for implantation to repair damaged articular surfaces.
A rationally designed self-standing V2O5 electrode for high voltage non-aqueous all-solid-state symmetric (2.0 V) and asymmetric (2.8 V) supercapacitors (2018)

The maximum capacitive potential window of certain pseudocapacitive materials cannot be accessed in aqueous electrolytes owing to the low dissociation potential of 1.2 V possessed by water molecules. However, the inferior pseudocapacitance exhibited by the commonly used electrode materials when integrated with non-aqueous electrolytes still remains a challenge in the development of supercapacitors (SC). Proper selection of materials for the electrode and a rational design process are indeed important to overcome these practical intricacies so that such systems can perform well with non-aqueous electrolytes. We address this challenge by fabricating a prototype all-solid-state device designed with high-capacitive V2O5 as the electrode material along with a Li-ion conducting organic electrolyte. V2O5 is synthesized on a pre-treated carbon-fibre paper by adopting an electrochemical deposition technique that effects an improved contact resistance. A judicious electrode preparation strategy makes it possible to overcome the constraints of the low ionic and electrical conductivities imposed by the electrolyte and electrode material, respectively. The device, assembled in a symmetrical fashion, achieves a high specific capacitance of 406 F g-1 (at 1 A g-1). The profitable aspect of using an organic electrolyte is also demonstrated with an asymmetric configuration by using activated carbon as the positive and V2O5 as the negative electrode materials, respectively. The asymmetric device displays a wide working-voltage window of 2.8 V and delivers a high energy density of 102.68 W h kg-1 at a power density of 1.49 kW kg-1. Moreover, the low equivalent series resistance of 9.9 Ω and negligible charge transfer resistance are observed in the impedance spectra, which is a key factor that accounts for such an exemplary performance.