gebhart/patrepeval huggingface dataset:
A Continuous Battle for Host-Derived Glycans Between a Mucus Specialist and a Glycan Generalist in vitro and in vivo (2021)

The human gastrointestinal tract is colonized by a diverse microbial community, which plays a crucial role in human health. In the gut, a protective mucus layer that consists of glycan structures separates the bacteria from the host epithelial cells. These host-derived glycans are utilized by bacteria that have adapted to this specific compound in the gastrointestinal tract. Our study investigated the close interaction between two distinct gut microbiota members known to use mucus glycans, the generalist <i>Bacteroides thetaiotaomicron</i> and the specialist <i>Akkermansia muciniphila in vitro</i> and <i>in vivo</i>. The <i>in vitro</i> study, in which mucin was the only nutrient source, indicated that <i>B. thetaiotaomicron</i> significantly upregulated genes coding for Glycoside Hydrolases (GHs) and mucin degradation activity when cultured in the presence of <i>A. muciniphila</i>. Furthermore, <i>B. thetaiotaomicron</i> significantly upregulated the expression of a gene encoding for membrane attack complex/perforin (MACPF) domain in co-culture. The transcriptome analysis also indicated that <i>A. muciniphila</i> was less affected by the environmental changes and was able to sustain its abundance in the presence of <i>B. thetaiotaomicron</i> while increasing the expression of LPS core biosynthesis activity encoding genes (<i>O-</i>antigen ligase, Lipid A and Glycosyl transferases) as well as ABC transporters. Using germ-free mice colonized with <i>B. thetaiotaomicron</i> and/or <i>A. muciniphila</i>, we observed a more general glycan degrading profile in <i>B</i>. <i>thetaiotaomicron</i> while the expression profile of <i>A. muciniphila</i> was not significantly affected when colonizing together, indicating that two different nutritional niches were established in mice gut. Thus, our results indicate that a mucin degrading generalist adapts to its changing environment, depending on available carbohydrates while a mucin degrading specialist adapts by coping with competing microorganism through upregulation of defense related genes.
Predicting SARS-CoV-2 infection among hemodialysis patients using multimodal data (2023)

As found in our study, the dynamics of the prediction model are frequently changing as the pandemic evolves. County-level infection information and vaccination information are crucial for the success of early COVID-19 prediction models. Our results show that the proposed model can effectively identify SARS-CoV-2 infections during the incubation period. Prospective studies are warranted to explore the application of such prediction models in daily clinical practice.
Active audition for humanoid robots that can listen to three simultaneous talkers (2003)

The direction-pass filter (DPF) separates sounds originating from a particular direction by using a pair of microphones embedded in each ear of humanoid robot. DPF first extracts harmonic structures from each channel, finds a corresponding pair on right and left channels, and then calculates their interaural phase difference (IPD) and interaural intensity difference (IID). These IPD and IID are matched with reference data obtained by HRTF or by the geometrical relation to determine the sound source direction. The direction obtained by face detection may be used as a candidate for the direction. Finally, all subbands from the direction are collected to synthesize a wave form by inverse FFT. The allowance of collection depends on the direction; narrow (10 deg) at center, while wide (30 deg) at the periphery. This property is called ‘‘auditory fovea’’ and is exploited by DPF actively to improve performance of sound source separation. In addition, a humanoid actively turns its head toward the speaker to listen better. Real-time DPF is implemented by distributed processing with five PCs. Preliminary experiments of active audition in speech recognition of three simultaneous utterances of digits in a normal room is also reported. [Work supported by JSPS.]
Embedded function composition (2009)

A low-level graphics processor is assembled from a collection of hardwired functions of screen coordinates embedded directly in the display. Configuration of these functions is controlled by a buffer containing parameters delivered to the processor on-the-fly during display scan. The processor is modular and scalable in keeping with the demands of large, high resolution displays.
Polyphase allpass IIR structures for sub-band acoustic echo cancellation (1993)

The advantages and current limitations of sub-band approaches to echo cancellation are reviewed. Polyphase allpass IIR halfband decimators and interpolators are presented. Their performance is compared to QMF structures in NLMS sub-band echo cancellation for hands-free telephone signals recorded in a car. The polyphase allpass IIR case is shown to give around 2 dB more ERLE with one fifth of the number of multiplies compared to direct form QMF.
Synthesis of nickel(II) isobacteriochlorins from nickel(II) complexes of chlorophyll derivatives (1985)

Treatment of nickel(II) methyl δ-meso-[(methylthio)methyl]mesopyropheophorbide a (1c) with Raney Ni gives the expected nickel(II) δ-meso-methyl compound 5 as well as byproducts, which are shown to be the nickel(II) isobacteriochlorin 2b, nickel(II) hexahydroporphyrin 4, and methyl nickel(II) δ-meso-methyldeoxomesopyropheophorbide a 3c. The nickel(II) isobacteriochlorin is shown to consist substantially of one isomer (2b, “tcc”) by using HPLC and high-field NMR spectroscopy. When the same reaction is carried out with the δ-meso-unsubstituted nickel(II) compound 9b, similar isobacteriochlorin 11a, hexahydroporphyrin 12, and deoxo compound 10b are obtained. In this case, the isobacteriochlorin is separated by HPLC into approximately equal amounts of two isomers. On the basis of extensive NMR experiments, structures for the two isomeric nickel (II) isobacteriochlorins are proposed. Variation of the solvent used in the Raney Ni reduction allows preferential formation of either the isobacteriochlorins 11a or the deoxo compound 10b, but under no circumstances are materials formed in which both the 9-ketocarbonyl and the ring A pyrrole subunit have been reduced. The presence of the δ-meso-methyl substituent (e.g., in 1c) also has an effect on the Raney Ni reaction such that significantly higher yields of nickel(II) isobacteriochlorin 2b are obtained (compared with reduction of 9b to give 11a). © 1985, American Chemical Society. All rights reserved.
Quantification of secretin stimulating effect on pancreatic exocrine function with magnetic resonance cholangiopancreatography (2005)

info:eu-repo/semantics/nonPublished
Combined optical AD conversion and page composition for holographic memory applications (1977)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Yoshito Tsunoda and Joseph W. Goodman, "Combined optical AD conversion and page composition for holographic memory applications," Appl. Opt. 16, 2607-2609 (1977) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A CMP solution enabling STT-RAM fabrication using via-less process flow (2014)

As current memory technologies become difficult to fabricate and scaling presents a growing challenge, R&D in Spin Transfer Torque Random Access Memory (STT-RAM) is growing rapidly. However, the complex stack of STT-RAM memory presents unique processing challenges. One of these is chemical mechanical planarization (CMP) of oxide and nitride for via-less top contacts. Unique materials used in STT-RAM fabrication require a selective and uniform planarization process. We evaluate ceria and silica slurries for this STT-RAM CMP process. Our results show that ceria-based slurry enables oxide-to-tantalum polish rate selectivity exceeding 100:1 and uniform planarization across the wafer. Electrical results of a device fabricated at Applied Materials show tunnel magneto-resistance (TMR) of 143% that is less than 10% degradation than the blanket film TMR.
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation (2016)

Tick saliva contains a number of effector molecules that inhibit host immunity and facilitate pathogen transmission. How tick proteins regulate immune signaling, however, is incompletely understood. Here, we describe that loop 2 of sialostatin L2, an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflammasome during infection with the rickettsial agent Anaplasma phagocytophilum Macrophages deficient in annexin A2 secreted significantly smaller amounts of interleukin-1β (IL-1β) and IL-18 and had a defect in NLRC4 inflammasome oligomerization and caspase-1 activation. Accordingly, Annexin a2-deficient mice were more susceptible to A. phagocytophilum infection and showed splenomegaly, thrombocytopenia, and monocytopenia. Providing translational support to our findings, better binding of annexin A2 to sialostatin L2 in sera from 21 out of 23 infected patients than in sera from control individuals was also demonstrated. Overall, we establish a unique mode of inflammasome evasion by a pathogen, centered on a blood-feeding arthropod.
ChemInform Abstract: Conjugate Addition of Organocuprates to trans‐4a,5,6,7,8,8a‐Hexahydronaphthalene‐1‐carboxaldehydes. (1986)

Abstract Die durch schwache Lewis‐Säuren katalysierte intramolekulare Diels‐Alder‐Reaktion des Trienals (I) führt mit hoher endo‐Selektivität zum trans‐Octahydronaphthalin(II), das zum Dienal (III) dehydriert wird.
ELECTROMAGNETIC RADIATION EMITTING DEVICE AND MANUFACTURING PROCESS THEREOF (2013)

The present invention relates to an electromagnetic radiation emitting device (LED 140) comprising at least one layer made of semiconductor material suitable for emitting a first electromagnetic radiation centered at a first wavelength and at least one wavelength converter layer (150) coated on said at least one layer made of semiconductor material. The wavelength converter layer is provided for at least partially converting the first electromagnetic radiation so that the resultant electromagnetic radiation is emitted by said emitting device centered at a second wavelength different from said first wavelength, the material (130) of the wavelength converter layer comprising nanostructured silicon (120). Furthermore the present invention relates to a manufacturing process of said device.
Recovery of Citrus By-Products and Specialty Products From Florida Citrus (1978)

The Florida Citrus Industry has come to realize that by-products and specialty products are important ingredients in the overall economic returns from citrus processing. The purpose of this paper is to show the potential recoveries of various commodities that can be produced from Valencia oranges, Marsh and Duncan grapefruit. It is hoped that these data will generate interest in improving present processes to obtain greater recoveries, and at the same time create a desire on the part of citrus processors to produce more sophisticated specialty products of greater economic value. Many different trade-offs and options are available in any given by-product operation, and it must be realized that not all of the products discussed can be produced simultaneously. Certainly future profits to a great extent, will be dependent on an adequate understanding of a more sophisticated by-product and specialty product technology. Paper published with permission.
Handheld real-time volumetric imaging of the spine: technology development (2014)

Technical difficulties, poor image quality and reliance on pattern identifications represent some of the drawbacks of two-dimensional ultrasound imaging of spinal bone anatomy. To overcome these limitations, this study sought to develop real-time volumetric imaging of the spine using a portable handheld device. The device measured 19.2 cm × 9.2 cm × 9.0 cm and imaged at 5 MHz centre frequency. 2D imaging under conventional ultrasound and volumetric (3D) imaging in real time was achieved and verified by inspection using a custom spine phantom. Further device performance was assessed and revealed a 75-min battery life and an average frame rate of 17.7 Hz in volumetric imaging mode. The results suggest that real-time volumetric imaging of the spine is a feasible technique for more intuitive visualization of the spine. These results may have important ramifications for a large array of neuraxial procedures.
US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report (2017)

This white paper summarizes the workshop U.S. Cosmic Visions: New Ideas in Dark Matter held at University of Maryland on March 23-25, 2017.
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure 3. Expression of PCAT29 in VCaP and LNCaP cells.&lt;/p&gt;
Direct Curvature Correction for Non-Contact Imaging Modalities-Applied to Multi-Spectral Imaging (2010)

Abstract not provided
Data from RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of <i>Pten</i>-Mutant Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;Genetically engineered mouse (GEM) models are a pillar of functional cancer research. Here, we developed RapidCaP, a GEM modeling system that uses surgical injection for viral gene delivery to the prostate. We show that in &lt;i&gt;Pten&lt;/i&gt; deficiency, loss of p53 suffices to trigger metastasis to distant sites at greater than 50% penetrance by four months, consistent with results from human prostate cancer genome analysis. Live bioluminescence tracking showed that endogenous primary and metastatic disease responds to castration before developing lethal castration resistance. To our surprise, the resulting lesions showed no activation of Akt but activation of the Myc oncogene. Using RapidCaP, we find that Myc drives local prostate metastasis and is critical for maintenance of metastasis, as shown by using the Brd4 inhibitor JQ1. Taken together, our data suggest that a “MYC-switch” away from AKT forms a critical and druggable event in &lt;i&gt;PTEN&lt;/i&gt;-mutant prostate cancer metastasis and castration resistance.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; The RapidCaP system introduces fast and flexible genetics for functional analysis and therapy for endogenous metastatic prostate cancer. The approach introduces targeting of MYC as a critical strategy against &lt;i&gt;PTEN&lt;/i&gt;-deficient lethal prostate cancer. &lt;i&gt;Cancer Discov; 4(3); 318–33. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;This article is highlighted in the In This Issue feature, p. 259&lt;/p&gt;&lt;/div&gt;
The photolysis of the l‐cycloalkoxy‐5‐chloro‐1,2,3‐benzotriazole system (1980)

Abstract Three l‐cycloalkoxy‐5‐chloro‐1,2,3‐benzotriazoles were photolyzed at 254 nm. The major photolytic pathway yielded the corresponding cyclic ketone and 4,4′‐dichloroazobenzene.
Deterioration Analysis of Lithium Metal Anode in Full Cell during Long-Term Cycles (2019)

The cross-section of the lithium metal anode was observed by a scanning electron microscope (SEM)-energy dispersive X-ray spectroscopy (EDS) in order to investigate the morphological change of lithium metal anode during long-term cycles in the laminate-type lithium metal rechargeable battery. Electrochemical impedance spectroscopy was carried out to confirm the resistance of the cell. Metallic lithium was consumed by the side reactions at the interface between electrolyte and deposited lithium, resulting in low coulombic efficiency (CE). Film-shape deposits, which were considered to be the surface films formed by side reactions at the interface between electrolyte and deposited lithium, were observed in the cycled anodes. The resistive surface films is considered to inhibit the dissolution and deposition of lithium. Furthermore, it was observed that the layer consisting of the film-shape deposits became thicker with increasing cycle number. It is considered that the thick layer consisting of the film-shape deposits inhibits the mass transfer, resulting in the degradation of the anode.
ChemInform Abstract: Chirospecific Synthesis of (1S,3R)‐1‐Amino‐3‐(hydroxymethyl) cyclopentane, Precursor for Carbocyclic Nucleoside Synthesis. Dieckmann Cyclization with an α‐Amino Acid. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P3561Detection and functional characterization of angiotensin receptor type 1 autoantibodies: establishment and clinical translation (2019)

Abstract Circulating AT1R autoantibodies (AT1R-aabs) directed against the ECL2 of the AT1R with agonist-like activity are supposed to play a pathophysiological role in diseases associated with vascular and renal damage, such as preeclampsia and severehypertension (HT), but they are also thought to be involved in heart failure and primary hyperaldosteronism (PHA). Methods High-throughput screening assays aiming at a reliable detection of AT1R-aabs in sera from patients with HT and PHA were established. The agonist-like activity of AT1R-aabs was assessed by changes in intracellular calcium-levels using Fura2-QBT dye; the AlphaLISA Assay was used to assess induction of ERK1/2-phosphorylation in stably transfected AT1R-HEK-cells or in adrenocortical NCI-H295R cells. Results IgG isolated from sera of n=60 patients with PHA and n=164 with HT were screened for their capacity to increase [Ca2+]i or to activate ERK1/2. Sixteen out of 60 PHA-patients increased [Ca2+]i compared to none of the HT-patients, whereas in both disease-entities we detected AT1R-aabs inducing ERK1/2-activation with a similar prevalence (PHA: 41%, HT: 42%), indicating the existence of differentially acting AT1R-aabs. PHA-patients positive for ERK1/2-activating AT1R-aabs have significantly lower serum potassium- (3,8±0,1 vs. 4,1±0,1 mmol/l, p&lt;0,05) and renin-levels (2,7±0,5 vs. 4,5±0,7 ng/l, p&lt;0,05) together with an increased aldosterone concentration (341±37 vs. 236±20 ng/l, p&lt;0,01) concordant with the disease phenotype. Similarly, higher BP values are observed in AT1R-aab positive HT-patients (syst/diast: 148/85 vs. 167/93 mmHg, p&lt;0,0001) accompanied byhigher aldosteroneserum-levels (93±7 vs. 74±3 ng/l, p&lt;0,05). In addition, ERK1/2-activation induced by either angiotensin II or by IgG isolated from patients with PHA or HT could be differentially blocked by the use of various signaling inhibitors. In order to elucidate if stimulating AT1R-aabs could be involved in an over-secretion of aldosterone due to sustained receptor-activation, we investigatedtheir effects on NCI-H295R-cells. At the transcriptional level, AT1R-aabs were able to induce a time-dependent upregulation of the key steroidogenic enzymes involved in aldosterone biosynthesis CYP21A1-, HSD3B2-, CYP11B1-, and in particular CYP11B2-mRNA (2fold over basal), with the maximum level achieved after 8 to 12 hours. Concordant withan agonist-stimulated internalization of AT1R,AT1R-mRNA was downregulated by AT1R-aabs (up to 25% of basal) providing direct evidence of a chronic receptor-stimulation by AT1R-aabs. Conclusion Functional assays based on AT1R-activation (Ca2+ measurements &amp; ERK1/2-phosphorylation) are able to detect AT1R-aabs in 41% or 42% of patients with HT or PHA, respectively. Moreover, our data provide evidence that AT1R-aabs stabilize a specific AT1R-conformation distinct from that induced by angiotensin II thereby triggering a different intracellular signaling pattern resulting in chronic aldosterone production. Acknowledgement/Funding BMBF grant
Synthesis and Structure Determination of (hfac)Ag(SEt2), Pd(hfac-C)(hfac-O,O)(SEt2), and [(hfac)Ag]4(SEt2): Ligand Exchange Reactions Relevant to Aerosol-Assisted Chemical Vapor Deposition (AACVD) of Ag1-xPdx Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Structure Determination of (hfac)Ag(SEt2), Pd(hfac-C)(hfac-O,O)(SEt2), and [(hfac)Ag]4(SEt2): Ligand Exchange Reactions Relevant to Aerosol-Assisted Chemical Vapor Deposition (AACVD) of Ag1-xPdx FilmsChongying Xu, Mark J. Hampden-Smith, Toivo T. Kodas, Eileen N. Duesler, Arnold L. Rheingold, and Glenn YapCite this: Inorg. Chem. 1995, 34, 19, 4767–4773Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ic00123a008https://doi.org/10.1021/ic00123a008research-articleACS PublicationsRequest reuse permissionsArticle Views194Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Smart Gas Sensing and Actuation Using Multimode of a MOFs Coated Microbeam (2018)

Smart sensing systems suffers complexity requiring interface circuits, microcontrollers, switches, and actuators to detect and sense, process the signal and take a decision, and trigger an action upon demand. This increases the device footprint and boosts significantly the power required to actuate the system. Here, we present a hybrid sensor and switch device, which is capable of accurately measuring gas concentration and perform switching when the concentration exceeds specific (safe) threshold. The device is based on a clamped-clamped microbeam coated with metalorganic frameworks (MOFs). Using the electrostatic harmonic voltage, we employ dynamic multi-modal actuation in which the microbeam is simultaneously excited at the first mode of vibration, near the pull-in band, and at the third mode. We demonstrate experimentally the effectiveness of this technique in measuring the concentration of water vapor and achieving switching when the concentration exceeds a threshold value. In contrast to a single mode operation, we show that employing multi-modal excitation enhances sensitivity, improves accuracy, and strengthen noise immunity.
Full vectorial mode solver for design and optimization of magneto-optic devices (2015)

In this work, we present a curl-curl formulation for computing the electromagnetic modes that propagate in a waveguide, fully or partially made with magneto-optic material. Such medium is characterized by a nonreciprocal permittivity tensor, which is responsible for a different propagation constant for the forward and backward traveling modes. By exploiting this property, an optical integrated isolator can be effectively designed and optimized. Finally, a detailed analysis based on the proposed finite element mode solver is performed to investigate the fabrication tolerance of the nonreciprocal waveguide.