gebhart/patrepeval huggingface dataset:
A design and implementation of 32-paths parallel 256-point FFT/IFFT for optical OFDM systems (2016)

This paper presents the design and implementation of thirty-two paths parallel FFT/IFFT for optical OFDM systems. Employing OFDM over high speed optical transmission systems requires large hardware resources due to computational-intensive operations such as full-parallel FFT implementation. The proposed 256-point FFT/IFFT adopts 32-paths parallel architecture with mixed radix-23 and radix-25 algorithm to reduce large number of complex multipliers. With this architecture, 256 full parallel data signals can be divided into eight sequential groups. Each group, composed of 32 parallel signals, is pipeline-processed. As a result, the hardware resources for full parallel 256-point FFT operation can be reduced to as much as those of 32-point FFT resource plus 32-path 8-point single-path delay feedback (SDF). The proposed FFT architecture is implemented with field programmable gate array and integrated in 12 Gbps, 64-QAM encoded real-time optical OFDM system. The implementation result shows that an 86% complex multiplier reduction can be achieved in comparison with full parallel architecture. The attained error vector magnitude (EVM) is approximately up to -32 dB for 64-QAM OFDM signals.
Mixed Metal Difluorides as High Capacity Conversion‐Type Cathodes: Impact of Composition on Stability and Performance (2018)

Abstract With the most recent development of ultrahigh capacity anodes, such as Li‐ or Si‐based anodes, metal fluorides hold promise as complementary high‐capacity conversion cathode materials for next‐generation energy storage devices. Despite their higher theoretical energy density compared to cells with sulfur cathodes, these materials have received dramatically less attention and little is understood about the origins of their electrochemical behavior. Here, the successful methodology to produce highly uniform size‐controlled mixed metal difluoride nanocomposites is reported. It is discovered that such materials undergo reduction in a single step with a reduction potential intermediate to those for the corresponding single‐metal difluorides and that a solid solution is reformed upon charging, which is advantageous for practical applications. For the first time the progressive formation of metal trifluorides upon repeated cycling of difluorides is reported. Systematic electrochemical measurements in combination with postmortem analyses lead to the conclusion that the cathode stability strongly depends on the ability to prevent formation and growth of a resistive cathode solid electrolyte interphase, which, in turn, strongly depends on the metal composition. This methodology and new findings will help to elucidate a path to developing metal fluoride–based commercial Li‐ion batteries and provide guidelines for material selection.
Adult neurogenesis in neurological diseases (2021)

Dysregulated inflammatory responses and neuron maturation are observed in diseased human brains.
Dataset on a ferroelectric based electrostatic and electrochemical Li-cell with a traditional cathode (2020)

Here we show the electrochemical raw data for a Li/ferroelectric Li-glass electrolyte/plasticizer/Li-rich, F doped LNMO coin cell where the plasticizer is succinonitrile-SN. The nominal composition of the active oxide-host cathode particles is Li<sub>1.36</sub>Ni<sub>0.49</sub>Mn<sub>1.15</sub>O<sub>3.28</sub>F<sub>0.36</sub> (LNMO) that disproportionated into 78 wt% spinel phase LiNi<sub>1/2</sub>Mn<sub>3/2</sub>O<sub>3.8</sub>F<sub>0.2</sub> and 22 wt% Li-rich, F-doped layered phase containing Li<sub>2</sub>MnO<sub>3</sub> planes separated by Li<sup>+</sup> and Ni<sup>2+</sup> ions. The Li<sub>2.99</sub>Ba<sub>0.005</sub>OCl electrolyte was synthesized and ground in ethanol. A cellulose matrix was dipped into the glass/ethanol slurry. This cell has been cycling for two years and six months. The electrochemical performance was firstly published in graphs after cycling the cell for about one year and three months [1]. The Li//LNMO CR2032 coin cell was assembled in an argon-filled glove box and electrochemically tested in a battery testing analyzer (LAND) at room temperature and at constant specific current densities and potentials between 2.5 and 4.8 V. Moreover, the cell's cycling current is 23 mA g<sup>-1</sup> (active cathode). The data might be used by the electrochemical (in particular, battery), electrostatic and ferroelectric researchers and industrials for comparative analysis. Furthermore, it can be reused by anyone interested in solid-state devices that wants to calculate the maximum energy stored electrostatically in these devices.
Test results of an adaptive deformable mirror for future large telescopes (2008)

Light traveling from a star suffers from optical distortion caused by the earthâs atmosphere. Adaptive optics (AO) is used in ground-based telescopes to correct these distortions (figure 1). In an AO system a real-time control system drives a deformable mirror based on information from the wavefront sensor.
Molecular Engineering of Covalent Organic Framework Cathodes for Enhanced Zinc‐Ion Batteries (2021)

Covalent organic frameworks (COFs) are potentially promising electrode materials for electrochemical charge storage applications thanks to their pre-designable reticular chemistry with atomic precision, allowing precise control of pore size, redox-active functional moieties, and stable covalent frameworks. However, studies on the mechanistic and practical aspects of their zinc-ion storage behavior are still limited. In this study, a strategy to enhance the electrochemical performance of COF cathodes in zinc-ion batteries (ZIBs) by introducing the quinone group into 1,4,5,8,9,12-hexaazatriphenylene-based COFs is reported. Electrochemical characterization demonstrates that the introduction of the quinone groups in the COF significantly pushes up the Zn<sup>2+</sup> storage capability against H<sup>+</sup> and elevates the average (dis-)charge potential in aqueous ZIBs. Computational and experimental analysis further reveals the favorable redox-active sites that host Zn<sup>2+</sup> /H<sup>+</sup> in COF electrodes and the root cause for the enhanced electrochemical performance. This work demonstrates that molecular engineering of the COF structure is an effective approach to achieve practical charge storage performance.
Continuous-flow high temperature and pressure water sterilizer (2015)

Water sterilization at sterility assurance levels exceeding 10−6 has been achieved with a novel high temperature and pressure sterilization system (HAPSS) capable of continuous-flow sterilization. The tested sterilizer produces &amp;gt;2,000 L/day and does not require filters, moving parts, or regular maintenance and can operate for multiple years with only water and standard voltage/amperage electricity. Sterility assurance levels were determined using Geobacillus stearothermophilus spores with inactivation experiments as a function of temperature and flow rate (i.e., duration/dosage at given temperature). Sterility of 1.0 × 104 CFU/mL G. stearothermophilus spore suspensions was achieved at the highest water flow rate of 1.4 L/min at 140 and 130 °C. The low cost and maintenance-free operation of HAPSS is envisioned to impact water sterilization needs of developing nations, hospitals, and commercial point of use applications.
DNA: new class of polymer (2006)

Suitable organic and polymeric based materials for electronic and photonic applications must possess the desired electromagnetic and optical properties to achieve optimal device performance in order to be more competitive with their inorganic counterparts. A new class of biopolymer, processed from purified marine-based deoxyribonucleic acid (DNA), has been investigated for use in both electronic and photonic applications and has demonstrated promise as an excellent dielectric and optical waveguide material. In this paper we present examples of devices using this new DNA-based biopolymer.
Via hole, bond wire and shorting pin modeling for multi-layered circuits (2002)

This paper presents a full-wave spectral-domain analysis to model generalized three-dimensional circuits for multilayered structures. To describe properly the current along the vertical post, such as via holes, bond wires and shorting pins, etc., the simple pulse function is used in the procedure of the moment method. Several numerical techniques are applied to improve the evaluation of matrix elements. Comparison of numerical results with experimental and available analytical data shows good agreement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia (2021)

Alzheimer's disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer's dementia.
Search for anomalous production of multilepton events in pp collisions at $ \sqrt {s} = 7\,TeV $ (2012)

We report a search for the anomalous production of events with multiple charged leptons in pp[over] collisions at sqrt[s]=1.96 TeV using a data sample corresponding to an integrated luminosity of 346 pb(-1) collected by the CDF II detector at the Fermilab Tevatron. The search is divided into three-lepton and four-or-more-lepton data samples. We observe six events in the three-lepton sample and zero events in the > or =4-lepton sample. Both numbers of events are consistent with standard model background expectations. Within the framework of an R-parity-violating supergravity model, the results are interpreted as mass limits on the lightest neutralino (chi[over](1)(0)) and chargino (chi[over](1+/-) particles. For one particular choice of model parameters, the limits are M(chi[over](1)(0)>110 GeV/c2 and M(chi[over](1+/-)>203 GeV/c2 at 95% confidence level; the variation of these mass limits with model parameters is presented.
The material point method for simulating continuum materials (2016)

Simulating the physical behaviors of deformable objects and fluids has been an important topic in computer graphics. While the Lagrangian Finite Element Method (FEM) is widely used for elasto-plastic solids, it usually requires additional computational components in the case of large deformation, mesh distortion, fracture, self-collision and coupling between materials. Often, special solvers and strategies need to be developed for a particular problem. Recently, the hybrid Eulerian/Lagrangian Material Point Method (MPM) was introduced to the graphics community. It uses a continuum description of the governing equations and utilizes user-controllable elasto-plastic constitutive models. The hybrid nature of MPM allows using a regular Cartesian grid to automate treatment of self-collision and fracture. Like other particle methods such as Smoothed Particle Hydrodynamics (SPH), topology change is easy due to the lack of explicit connectivity between Lagrangian particles. Furthermore, MPM allows a grid-based implicit integration scheme that has conditioning independent of the number of Lagrangian particles. MPM also provides a unified particle simulation framework similar to Position Based Dynamics (PBD) for easy coupling of different materials. The power of MPM has been demonstrated in a number of recent papers for simulating various materials including elastic objects, snow, lava, sand and viscoelastic fluids. It is also highly integrated into the production framework of Walt Disney Animation Studios and has been used in featured animations including Frozen, Big Hero 6 and Zootopia.
Structure-function analysis of the DNA binding domain ofSaccharomyces cerevisiaeABF1 (1995)

To localize the DNA binding domain of the Saccharomyces cerevisiae Ars binding factor 1 (ABF1), a multifunctional DNA binding protein, plasmid constructs carrying point mutations and internal deletions in the ABF1 gene were generated and expressed in Escherichia coli. Normal and mutant ABF1 proteins were purified by affinity chromatography and their DNA binding activities were analyzed. The substitution of His61, Cys66 and His67 respectively, located in the zinc finger motif in the N-terminal region (amino acids 40-91), eliminated the DNA binding activity of ABF1 protein. Point mutations in the middle region of ABF1, specifically at Leu353, Leu399, Tyr403, Gly404, Phe410 and Lys434, also eliminated or reduced DNA binding activity. However, the DNA binding activity of point mutants of Ser307, Ser496 and Glu649 was the same as that of wild-type ABF1 protein and deletion mutants of amino acids 200-265, between the zinc finger region and the middle region (residues 323-496) retained DNA binding activity. As a result, we confirmed that the DNA binding domain of ABF1 appears to be bipartite and another DNA binding motif, other than the zinc finger motif, is situated between amino acid residues 323 and 496.
A STUDY OF AN EVALUATION METHOD FOR PASSING AND NO PASSING SECTIONS IN ROAD IMPROVEMENT FOR 1.5 LANES (2017)

中山間地域における豊かな暮らしを支えるため，近年，1車線改良や2車線改良，局部改良を弾力的に組合せた1.5車線的道路での整備が可能になった．建設工事においても，一時的な大型車の増加に対応する上で1.5車線的道路が有効となるが，交通量の多い区間では，待避所の位置や延長を設定するために労力や時間を要する交通シミュレーション等による検討を繰り返す必要があった．本稿では，繰り返し検証の省力化と待避所の最適配置を視野に，狭隘区間と待避区間の評価指標を定式化して交通シミュレーションとの比較を行った．両者の平均絶対誤差は，平均待ち時間で4.8秒，平均必要待避区間長で3.3mとなり，本指標の妥当性を確認できた．今後，最適化手法と組合せることで，待避区間の最適配置と迅速で効果的な整備計画の策定が可能になると考える．
A Third Life for Burimamide: Discovery and Characterization of a Novel Class of Non‐Opioid Analgesics Derived from Histamine Antagonists (2000)

Burimamide, a histamine (HA) derivative with both H2- and H3-blocking properties, induces antinociception when injected into the rodent CNS. Several related compounds share this property, and structure-activity studies have shown that this new class of analgesics is distinct from known HA antagonists. The prototype, named improgan, shows a preclinical profile of a highly effective analgesic, with activity against thermal, mechanical and inflammatory nociception after doses that do not alter motor balance or locomotor activity. Improgen analgesia is not blocked by opioid antagonists and is observed in opioid receptor knock-out mice. Unlike morphine, improgan does not induce tolerance after daily dosing. Extensive in vitro pharmacology studies have excluded known histaminergic, opioid, serotonergic, GABAergic and adrenergic receptor mechanisms, as well as 50 other sites of action. The improgan-like analgesic activity of some HA congeners suggests an analgesic action on a novel HA receptor, but further studies are required to substantiate this. Studies in progress are characterizing the sites and mechanisms of action of improgan, and developing brain-penetrating derivatives that could be useful for clinical pain.
Targeting Viral-Mediated Transduction to the Lung Airway Epithelium with the Anti-inflammatory Cationic Lipid Dexamethasone–Spermine (2005)

We formulated adenovirus (AdV) vectors with cationic steroid liposomes containing dexamethasone-spermine (DS)/dioleoylphosphatidylethanolamine (DOPE) in an effort to overcome the lack of apically expressed AdV vector receptors on airway epithelial cells and to reduce the inflammation associated with AdV vector exposure. An AdV vector (1 to 2.5 x 10(11) genome copies) expressing human placental alkaline phosphatase or beta-galactosidase (LacZ) was delivered alone or complexed with DS/DOPE, DC-Chol/DOPE, or dexamethasone to C57Bl/6 mice via intranasal instillation. Formulation of the AdV vector with DS/DOPE and DC-Chol/DOPE resulted in transgene expression targeted only to the airway epithelial cells with minimal expression in alveolar cells, while AdV alone caused high alveolar transduction. The DS/DOPE and dexamethasone formulations greatly reduced cellular infiltrates compared to AdV vector alone, while formulation with DC-Chol/DOPE did not. IFN-gamma was significantly elevated at day 7 in mice receiving only the AdV vector compared to the AdV vector formulated with DS/DOPE, DC-Chol/DOPE, or dexamethasone. Lipid formulation of adeno-associated virus vector expressing LacZ also produced airway epithelial targeting, similar to the AdV vector. Viral vectors can be formulated with DS/DOPE to improve targeting to the airway epithelium in vivo and to attenuate vector-induced inflammation through the pharmacological activity of DS.
XRD, TEM, IR, Raman and NMR Spectroscopy of In Situ Crystallization of Lithium Disilicate Glass (2006)

The structure of a Li2O-2SiO2 (LS2) glass was investigated as a function of pressure and temperature up to 6 GPa and 750 C respectively, using XRD, TEM, IR, Raman and NMR spectroscopy. Glass densified at 6 GPa has an average Si-O-Si bond angle approx.7deg lower than that found in glass processed at 4.5 GPa. At 4.5 GPa, lithium disilicate crystallizes from the glass, while at 6 GPa a new high pressure form of lithium metasilicate crystallizes. The new phase, while having lithium metasilicate crystal symmetry, contains at least 4 different Si sites. NMR results for 6 GPa sample indicate the presence of Q4 species with (Q(sup 4))Si-O-Si(Q(sup 4)) bond angles of approx.157deg. This is the first reported occurrence of Q(sup 4) species with such large bond angles in alumina free alkali silicate glass. No five- or six- coordinated Si are found.
Endothelial Cells as Key Determinants of the Tumor Microenvironment: Interaction with Tumor Cells, Extracellular Matrix and Immune Killer Cells (2010)

Besides tumor cells, the tumor microenvironment harbors a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells. It is a complex and highly dynamic environment, providing very important cues to tumor development and progression. Tumor-associated endothelial cells play a key role in this process. On the one hand, they form tumor-associated (angiogenic) vessels through sprouting from locally preexisting vessels or recruitment of bone marrow-derived endothelial progenitor cells, to provide nutritional support to the growing tumor. On the other hand, they are the interface between circulating blood cells, tumor cells and the extracellular matrix, thereby playing a central role in controlling leukocyte recruitment, tumor cell behavior and metastasis formation. Hypoxia is a critical parameter modulating the tumor microenvironment and endothelial/tumor cell interactions. Under hypoxic stress, tumor cells produce factors that promote tumor angiogenesis, tumor cell motility and metastasis. Among these factors, VEGF, a main angiogenesis modulator, can also play a critical role in the control of immune tolerance. This review discusses some aspects of the role of endothelial cells within tumor microenvironment and emphasizes their interaction with tumor cells, the extracellular matrix and with immune killer cells. We will also address the role played by circulating endothelial progenitor cells and illustrate their features and mechanism of recruitment to the tumor microenvironment and their role in tumor angiogenesis.
<title>Figure metrology of deep general aspherics using a conventional interferometer with CGH null</title> (1995)

We present a simple and general method of aspheric figure metrology using a CGH null mounted in the test beam of a conventional Fizeau or Twyman-Green interferometer. A 'standard' reflective CGH is used to establish optical alignment with respect to the interferometer's spherical test beam. This alignment is then mechanically trnaferred to a custom CGH null. The accuaracy of the alignment transfer is readily verified. The test method has been modeled by raytracing and verified experimentally by testing a perforated 8 inch F/1.5 on-axis paraboloid and a 50 mm off-axis paraboloid from their centers of curvature.
Erratum: “Secular Evolution of Hierarchical Triple Star Systems” (ApJ, 535, 385 [2000]) (2004)

We derive octupole-level secular perturbation equations for hierarchical triple systems, using classical Hamiltonian perturbation techniques. By extending previous work done to leading (quadrupole) order to octupole level (i.e., including terms of order alpha^3, where alpha = a_1/a_2 < 1 is the ratio of semimajor axes) we obtain expressions that are applicable to a much wider range of parameters. For triple systems containing a close inner binary, we also discuss the possible interaction between the classical Newtonian perturbations and the general relativistic precession of the inner orbit. In some cases we show that this interaction can lead to resonances and a significant increase in the maximum amplitude of eccentricity perturbations. We establish the validity of our analytic expressions by providing detailed comparisons with the results of direct numerical integrations of the three-body problem obtained for a large number of representative cases. We also discuss applications of the theory in the context of several observed triple systems of current interest, including the millisecond pulsar PSR B1620-26 in M4, the giant planet in 16 Cygni, and the protostellar binary TMR-1. [short version]
Electrogastrographic and Autonomic Responses During Oculovestibular Recoupling in Flight Simulation (2013)

Electrogastrography and interbeat intervals are sensitive indices of autonomic changes in subjects undergoing flight simulation. These data demonstrate the potential of oculovestibular recoupling to stabilize gastric activity and cardiac autonomic changes altered during simulator and motion sickness.
The B6‐vitamer Pyridoxal is a Sensitizer of UVA‐induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis (2017)

UVA-driven photooxidative stress in human skin may originate from excitation of specific endogenous chromophores acting as photosensitizers. Previously, we have demonstrated that 3-hydroxypyridine-derived chromophores including B<sub>6</sub> -vitamers (pyridoxine, pyridoxamine and pyridoxal) are endogenous photosensitizers that enhance UVA-induced photooxidative stress in human skin cells. Here, we report that the B<sub>6</sub> -vitamer pyridoxal is a sensitizer of genotoxic stress in human adult primary keratinocytes (HEKa) and reconstructed epidermis. Comparative array analysis indicated that exposure to the combined action of pyridoxal and UVA caused upregulation of heat shock (HSPA6, HSPA1A, HSPA1L, HSPA2), redox (GSTM3, EGR1, MT2A, HMOX1, SOD1) and genotoxic (GADD45A, DDIT3, CDKN1A) stress response gene expression. Together with potentiation of UVA-induced photooxidative stress and glutathione depletion, induction of HEKa cell death occurred only in response to the combined action of pyridoxal and UVA. In addition to activational phosphorylation indicative of genotoxic stress [p53 (Ser15) and γ-H2AX (Ser139)], comet analysis indicated the formation of Fpg-sensitive oxidative DNA lesions, observable only after combined exposure to pyridoxal and UVA. In human reconstructed epidermis, pyridoxal preincubation followed by UVA exposure caused genomic oxidative base damage, procaspase 3 cleavage and TUNEL positivity, consistent with UVA-driven photooxidative damage that may be relevant to human skin exposed to high concentrations of B<sub>6</sub> -vitamers.