gebhart/patrepeval huggingface dataset:
Response Dynamics and Directional Properties Interneurons in the Cockroach Cereal System (1993)

The response properties and directional receptive fields of nonspiking local interneurons in the cereal system of the cockroach are described. Wind-evoked responses were recorded intracellularly, and then analyzed by means of the Wiener kernel method in which a Gaussian white noise signal was used as a stimulus. Cross-correlation between the response and the white noise signal produced first- (linear) and second-order (nonlinear) kernels that were used to define hrput-output characteristics of the interneurons. Three sets of interneurons were distinguished on the basis of kernel analysis. First, responses in interneurons 101,107, 111, and 203 were characterized predominantly by a differentiating, first-order kernel, which suggests a linear relationship to the stimulus. The amplitude and waveform of the kernel changed with the change in stimulus angle, indicating that these four cells are directionally sensitive. Second, responses in interneurons 102 and 103 were also directionally sensitive but highly nonlinear. The first-order kernel was biphasic, whereas the second-order kernel had an elongated depolarizing peak on the diagonal. The response dynamics were accounted for by a cascade of two filters, a linear band-pass filter and a static nonlinear filter, in which the nonlinearity is a signal compression (or a rectification). Third, responses in interneurons 104 and 201 consist largely of the second-order nonlinear component. The second-order kernel, which had an elongated depolarizing peak or a hyperpolarizing valley on the diagonal, did not show any directional preference. The second-order nonlinearity was dynamic, and could be modeled by a band-pass linear filter-static nonlinearity-low-pass linear filter cascade, where the static nonlinearity is a full-wave rectification. The band-pass filter would simply reflect the mechanical property of cereal hair sensilla, whereas the low-pass filter represents the transfer at synapses between the cereal afferents and the interneurons. The nonlinear response thus explains the difference in the directional sensitivity while the differentiating first-order kernel explains the velocity sensitivity of the interneurons. We show that 101 and 107 respond most preferentially to wind from the left versus right, whereas 102, 103, 111, and 203 respond to wind from the front versus rear. Thus, it is sug
InGaAs and InGaAs-On-Insulator n-Channel MOSFETs Fabricated by Self-Align Gate First Process with Ni/Al<sub>2</sub>O<sub>3</sub> Gate Stacks (2010)

2010 International Conference on Solid State Devices and Materials,InGaAs and InGaAs-On-Insulator n-Channel MOSFETs Fabricated by Self-Align Gate First Process with Ni/Al<sub>2</sub>O<sub>3</sub> Gate Stacks
The algebraic inversion of 2-D autoregressive power spectra with applications to spectral estimation (2005)

Some recent results concerning the evaluation of autocorrelation functions associated with 2-D autoregressive (AR) spectra are reviewed. In contrast to the 1-D case, 2-D AR autocorrelation functions can, in general, only be evaluated by means of a numerical integration. However, if the minimum-phase whitening filter for the AR process has finite reflection coefficient support, then the autocorrelation function can be evaluated algebraically, either by means of a "backward" 2-D Levinson algorithm, or by means of a partial fraction expansion. The special properties of 2-D AR spectra of this class make them potentially useful in the problem of finding correlation-matching spectral estimates. The possibility of performing 2-D covariance extension by fitting AR models with finite reflection coefficient Support iS partially explored.
Primary Tumors of the Spine (2008)

Primary neoplasms of the spine encompass a broad spectrum of tumors, ranging in their tissue of origin, local behavior, and potential for metastasis. The diagnosis and treatment of these disorders is accordingly varied. As a category, non-myeloproliferative primary tumors of the spine are rare, accounting for approx 5% of all bone tumors, when one excludes hemangiomas (1,2). In frequency, therefore, they are much less common than metastatic and/or myeloproliferative neoplasms involving the spine, as well as non-neoplastic processes such as infection, metabolic disorders, and other pathologies. The diagnosis of primary tumors of the spine, therefore, must occur with careful consideration of other more common entities. In this chapter, we discuss the common benign and malignant tumors that afflict the spinal column, and describe the appropriate algorithm for evaluating and treating these conditions.
A µ-oxo mixed-metal complex of copper(II) and an iron(III)-porphyrin as a resting state model for the cytochrome c oxidase active site (1982)

The complex (TPP)FeIV : O (TPP = tetraphenylporphyrin) reacts in solution with an imidazole-bearing CuI complex to form a stable mixed-metal µ-oxo-species, [Fe3+–O–Cu2+]+, as a resting state model compound for the binuclear active site of cytochrome c oxidase.
Photoelectric Properties in Organic Ultra Thin Films Comprising Merocyanine and Phthalocyanine (1998)

The photoelectric properties of Langmuir-Blodgett (LB) films, made of merocyanine, M-tetra-tert-butylphthalocyanine (M=Ni, Cu, OV) organic dye, have been studied. The films comprising Al electrode as low workfunction metal which is in contact with the dye layer was recognized to be Schottky barrier. The photoelectric characteristics have their origin in the Schottky barrier formed at the junction between the Al electrode and organic dye. Al/organic LB film/ITO structure were fabricated to investigate photoelectric properties. Mechanism of photoelectric effects are discussed on the basis of the J-V experimental results and the energy band.
Porous Supramolecular Assemblies for Efficient Suzuki Coupling of Aryl Chlorides (2023)

Abstract The development of catalytic systems that can activate aryl chlorides for palladium‐catalyzed cross‐coupling reactions is at the forefront of ongoing efforts to synthesize fine chemicals. In this study, a facile ligand‐template approach is adopted to achieve active‐site encapsulation by forming supramolecular assemblies; this bestowed the pristine inert counterparts with reactivity, which is further increased upon the construction of a porous framework. Experimental results indicated that the isolation of ligands by the surrounding template units is key to the formation of catalytically active monoligated palladium complexes. Additionally, the construction of porous frameworks using the resulting supramolecular assemblies prevented the decomposition of the Pd complexes into nanoparticles, which drastically increased the catalyst lifetime. These findings, along with the simplicity and generality of the synthesis scheme, suggest that the strategy can be leveraged to achieve unique reactivity and potentially enable fine‐chemical synthesis.
Out in the Cold: Advances in Holding Solutions (2006)

1. John M. Baust, PhD 1. Owega, New York Many hair transplant surgeons keep their grafts in chilled saline because of the perception that this results in greater tissue viability. The utilization of low temperature storage provides for an avenue to reduce the biochemical activity of a cell or
Cellular backpacks for macrophage immunotherapy (2020)

Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered particle referred to as a "backpack" that can robustly adhere to macrophage surfaces and regulate cellular phenotypes in vivo. Backpacks evade phagocytosis for several days and release cytokines to continuously guide the polarization of macrophages toward antitumor phenotypes. We demonstrate that these antitumor phenotypes are durable, even in the strongly immunosuppressive environment of a murine breast cancer model. Conserved phenotypes led to reduced metastatic burdens and slowed tumor growths compared with those of mice treated with an equal dose of macrophages with free cytokine. Overall, these studies highlight a new pathway to control and maintain phenotypes of adoptive cellular immunotherapies.
Transport Phenomena (2014)

No AccessPolymer RheologyNov 2014Transport PhenomenaTim Osswald, Natalie RudolphTim OsswaldSearch for more papers by this author, Natalie RudolphSearch for more papers by this authorhttps://doi.org/10.3139/9781569905234.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2014Pages: 101-141Print ISBN: 978-1-56990-517-3eISBN: 978-1-56990-523-4 Copyright & Permissions© 2015 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
POTENTIAL ROLE FOR NESTIN, A NEURAL STEM CELL MARKER, IN THE PATHOPHYSIOLOGY OF INJURY AND REPAIR OF THE CAVERNOUS NERVE (2009)

You have accessJournal of Urology1 Apr 2009POTENTIAL ROLE FOR NESTIN, A NEURAL STEM CELL MARKER, IN THE PATHOPHYSIOLOGY OF INJURY AND REPAIR OF THE CAVERNOUS NERVE Trinity J Bivalacqua, Travis D Strong, Edward M Schaeffer, Christian P Pavlovich, Hunter C Champion, and Arthur L Burnett Trinity J BivalacquaTrinity J Bivalacqua More articles by this author , Travis D StrongTravis D Strong More articles by this author , Edward M SchaefferEdward M Schaeffer More articles by this author , Christian P PavlovichChristian P Pavlovich More articles by this author , Hunter C ChampionHunter C Champion More articles by this author , and Arthur L BurnettArthur L Burnett More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60685-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "POTENTIAL ROLE FOR NESTIN, A NEURAL STEM CELL MARKER, IN THE PATHOPHYSIOLOGY OF INJURY AND REPAIR OF THE CAVERNOUS NERVE." The Journal of Urology, 181(4S), p. 241 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 241 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Trinity J Bivalacqua More articles by this author Travis D Strong More articles by this author Edward M Schaeffer More articles by this author Christian P Pavlovich More articles by this author Hunter C Champion More articles by this author Arthur L Burnett More articles by this author Expand All Advertisement PDF downloadLoading ...
On thin-clients and the cloud; can smartphones and tablets really reduce electricity consumption? (2014)

Cloud computing suggests that we can move many computational and data storage services from the desktop onto the network. New thin clients provide an excellent user interface for cloud services and also reduce both manufacturing electricity and lifetime electricity use by an order of magnitude. But do they really reduce overall electricity consumption? In this paper we examine how the total electricity consumption due to consumer computing devices is evolving. We attempt to estimate its growth in terms of global electricity consumption and determine longer term trends due to the rapid growth in thin-clients and the broad adoption of cloud computing.
Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer (2014)

Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators. Since its discovery over two decades ago, SRSF1 has been repeatedly surprising and intriguing investigators by the plethora of complex biologic pathways it regulates. These include several key aspects of mRNA metabolism, such as mRNA splicing, stability, and translation, as well as other mRNA-independent processes, such as miRNA processing, protein sumoylation, and the nucleolar stress response. In this review, the structural features of SRSF1 are discussed as they relate to the intricate mechanism of splicing and the multiplicity of functions it performs. Similarly, a list of relevant alternatively spliced transcripts and SRSF1 interacting proteins is provided. Finally, emphasis is given to the deleterious consequences of overexpression of the SRSF1 proto-oncogene in human cancers, and the complex mechanisms and pathways underlying SRSF1-mediated transformation. The accumulated knowledge about SRSF1 provides critical insight into the integral role it plays in maintaining cellular homeostasis and suggests new targets for anticancer therapy. Mol Cancer Res; 12(9); 1195-204. ©2014 AACR.
High power 1.5- mu m DFB laser diode for long haul optical transmission system (1988)

Lasing characteristics, reliability and transmission performance of a high power 1.5- mu m InGaAsP DFB laser are reported. The validity of the highpower DFB laser for practical applications has been verified by the aging tests at 70 degrees C, 15 mW output power and the transmission experiment at 680 Mb/s using 160-km 1.3- mu m zero dispersion fiber.
Enantioselective Synthesis of (2S)‐2‐Amino‐3‐(4‐hydroxy‐3‐phosphonophenyl)propionic Acid (= 3′‐Phosphono‐L‐tyrosine) and Its Incorporation into Peptides (1993)

Abstract The asymmetric synthesis of derivatives of the new amino acid (2 S )‐2‐amino‐3‐(4‐hydroxy‐3‐phosphono‐phenyl)propionic acid (3′‐phosphono‐ L ‐tyrosine; Tyr [3′‐PO(OH) 2 ]) is described. The protected amino acid 13 is obtained via a Schöllkopf synthesis by coupling of the rearranged ortho ‐phosphonophenolic side chain (see Scheme 1 , 6a ) with the lithiated bis‐lactim ether 8 of cyclo(‐ D ‐valyl‐glycyl‐) (see Scheme 2 ). The incorporation of the protected amino acid 14 in a biologically active dodecapeptide is successfully achieved by the [(9 H ‐fluoren‐9‐yl)‐methoxy]carbonyl (Fmoc) strategy of solid‐phase peptide synthesis. Differential protection of Tyr[3′‐PO(OH) 2 ] provides four levels of selective deprotection of, in the order, the N 2 ‐amino, the carboxyl (cleavage from the resin), the phenol, and the phosphono function (→ peptide 16 ).
MetaCores (2001)

Currently, hardware intellectual property (IP) is delivered at three levels of abstraction: hard, firm, and soft. In order to further enhance performance, efficiency, and flexibility of IP design, we have developed a new approach for designing hardware and software IP called MetaCores. The new design approach starts at the algorithm level and leverages on the algorithms intrinsic optimization degrees of freedom. The approach has four main components: (i) problem formulation and identification of optimization degrees of freedom, (ii) objective functions and constraints, (iii) cost evaluation engine, and (iv) multiresolution design space search. From the algorithmic viewpoint, the main contribution is the introduction of multiresolution search in algorithm optimization and synthesis process. We have applied the approach to the development of Viterbi and IIR MetaCores. Experimental results demonstrate the effectiveness of the new approach.
The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials (2019)

Andrew Vernon and co-authors discuss adherence to therapy and its measurement in tuberculosis treatment trials.
Role of Peyer's patches in the induction of Helicobacter pylori -induced gastritis (2007)

Helicobacter pylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Although Th1 immunity is involved in gastritis and the accumulation of H. pylori-specific CD4(+) T cells in the H. pylori-infected gastric mucosa in human patients, how T cells are primed with H. pylori antigens is unknown because no apparent lymphoid tissues are present in the stomach. We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. pylori-infected mice lacking PPs. We also observed that the coccoid form of H. pylori is phagocytosed by dendritic cells in PPs. We propose that H. pylori converts to the coccoid form in the anaerobic small intestine and stimulates the host immune system through PPs.
Numerical Simulation of Solute Transport in Fractured Rock with Particle Tracking Method (2017)

In this work an open source scientific software platform OpenGeoSys (OGS) was utilized for the simulation of fluid flow and solute transport in fractured porous media. A particle based method was proposed which takes use of velocities calculated by finite element method (FEM) to obtain flow patterns, and in which the distribution of the solute mass is represented by particle plume and can be quantitatively obtained by counting the number of particles. Two benchmarks were developed in order to verify the proposed method: one was to simulate solute transport in two dimensional steady flow through infinite fractured porous media with one single crack; the other was to simulate solute transport in an artificial rock fracture in novaculite under laboratory conditions. The simulation results showed that the proposed particle tracking method agreed well with the classical FEM simulation methods. The particle plume could exhibit the flow pattern, as well as the detailed channeling effects and accelerations or decelerations in some regions. This method can be applied as a tool to observe the detailed structure of evolving contaminant plumes in fractured rock.
LARGE AREA PIEZOELECTRIC ACTUATORS USING METAL FOIL SUBSTRATES WITH Pb(Zrx,Ti1 - x)O3 THIN FILMS (2008)

ABSTRACT We report on the deposition of Pb(Zrx,Ti1 - x)O3 (PZT) thin films by chemical solution deposition (CSD) on stainless steel foils. The electrical characterization proves good ferroelectric properties with a remnant polarization of 38 μ C/cm2. Since PZT is also piezoelectric the 35 μ m and 50 μ m thick metal foils are used to make piezoelectric actuated cantilever beams of several millimeter lengths. Actuated with 10–30 V a displacement up to 32 μ m was measured in quasi-static mode. In resonance mode the displacement increases several times at the same driving voltage.
Magnetic Resonance Navigation of a Bead Inside a Three-Bifurcation PMMA Phantom Using an Imaging Gradient Coil Insert (2014)

This paper reports the successful navigation of a 1-mm Chrome-Steel bead along three consecutive polymethyl methacrylate channels inside the bore of a 1.5-T magnetic resonance imaging (MRI) scanner. The bead traveled at a mean velocity of 14 cm·s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . This was accomplished using an imaging gradient coil (IGC) insert located inside the MRI tube. While targeting one side of a bifurcation has been previously demonstrated using unidirectional gradient coils, this is the first time that magnetic resonance navigation (MRN) of a bead along consecutive channels is reported. Experimental results confirm that a clinical regular MRI can be used to propel a 1-mm device. In addition, when used at maximum power, IGC temperature rise becomes a serious issue that can ultimately damage the insert and limit the overall performance. Consequently, this paper aims to give some insight into coil temperature management for IGC-assisted procedures. A 33-min thermal stress test was carried out using 100% of the IGC power. Steady-state oscillation can be reached by interleaving propulsion periods with cooling periods, thus enabling longer propulsion procedures. Experimental data showed that the cooling time can be used for imaging purposes with no performance loss, thus enabling MRN-assisted procedures with multiplexed particle distribution assessment.
The antitumor effects of anthracyclines. The importance of the carbomethoxy-group at position-10 of marcellomycin and rudolfomycin. (1979)

Volume 15, (1979) in the article Antitumor Effects of Anthracyclines. The Importance of the Carbomethoxy-Group at Position-l0 of Marcellomycin and Rudolfomycin, pp. 341-356 by V. H. DuVernay, J. M. Essery, T. W. Doyle, W. T. Bradner and S. T. Crooke: p. 351, figure 7 should be as shown. See PDF for Figure The corrected figure contains a drug concentration axis with values ranging from 0.001 µM up to 100 µM (in log increments).
The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome (2009)

The Endocrine Tumor Summit convened in December 2008 to address 6 statements prepared by panel members that reflect important questions in the treatment of acromegaly and carcinoid syndrome. Data pertinent to each of the statements were identified through review of pertinent literature by one of the 9-member panel, enabling a critical evaluation of the statements and the evidence supporting or refuting them. Three statements addressed the validity of serum growth hormone (GH) and insulin-like growth factor-I (IGF-I) concentrations as indicators or predictors of disease in acromegaly. Statements regarding the effects of preoperative somatostatin analog use on pituitary surgical outcomes, their effects on hormone and symptom control in carcinoid syndrome, and the efficacy of extended dosing intervals were reviewed. Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons.
Activated Carbon Canister Performance During Diurnal Cycles: An Experimental and Modeling Evaluation (1997)

&lt;div class="htmlview paragraph"&gt;A vehicle's evaporative emission control system is continuously working, even when the vehicle is not running, due to generation of vapors from the fuel tank during ambient temperature variations. Diurnal temperature cycles cause the fuel tank to breathe the fuel vapor in and out, and thus the activated carbon canister is constantly loading and purging the hydrocarbon vapors.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper discusses a study undertaken at Ford to evaluate the relationship between carbon canister condition and fuel tank vapor generation during diurnal cycles. The results of an extensive set of experiments are presented, and the data from these experiments are compared to the output of a fuel vapor system model also developed at Ford. Key parameters relating to the migration of hydrocarbons during the experimental conditions studied, including initial canister condition, canister volume, and canister geometry, are discussed.&lt;/div&gt;
Supplementary Figure S5 from E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models (2023)

&lt;p&gt;Western blot analysis of FGFR1 in human lung cancer cell lines harboring FGFR1 amplifications.&lt;/p&gt;