gebhart/patrepeval huggingface dataset:
104-OR: Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First-in-Human Dose Study in Healthy Subjects (2021)

Multifunctional incretins are in clinical development for several metabolic conditions. Novel LY3437943 has potent agonist activity on glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon receptors. The primary objective of this randomized, double-blind, placebo (PBO)-controlled, Phase 1, first in human study was to assess safety and tolerability of single-ascending doses of LY3437943. Forty-five healthy subjects were randomized (6:2) to subcutaneous LY3437943 (6 rising dose levels) or PBO. Vital signs, ECGs, laboratory data and adverse events (AEs) were monitored to assess safety and tolerability. LY3437943 pharmacokinetics (PK) as well as change from baseline (BL) in fasting insulin, C-peptide and weight were measured. Appetite was assessed using a visual analog scale (VAS). The most common treatment-emergent AEs were gastrointestinal, including vomiting (with higher doses), abdominal distention and nausea, which were dose-dependent, mostly mild in severity, occurred within 4 days of dosing and resolved within a week of onset. Dose-dependent increases in heart rate and decreases in systolic blood pressure were observed, which returned to near BL by Day 29. Mean terminal half-life of LY3437943 ranged from 134-165 h (∼7 days) across the 6 doses, supporting once-weekly dosing. Dose-dependent increases in mean fasting insulin and C-peptide, with maximum levels observed at 24 and 48 h, returned to near BL by Day 15. Dose-dependent weight loss was statistically significant with the 3 highest doses vs. PBO (up to 3.5 kg at the highest dose). Weight loss was maintained up to Day 43 following single administration of the two highest doses. Overall VAS score significantly increased with higher doses vs. PBO, reflecting decreased appetite. Triple-agonist peptide LY3437943 had a safety and tolerability profile similar to other incretins in Phase 1 trials with PK and pharmacodynamic outcomes that support further clinical evaluation. Disclosure S. Urva: Employee; Self; Eli Lilly and Company. Y. Du: None. M. K. Thomas: Employee; Self; Eli Lilly and Company, Stock/Shareholder; Self; Eli Lilly and Company. Z. Milicevic: Employee; Self; Eli Lilly and Company. T. Coskun: Employee; Self; Eli Lilly and Company, Stock/Shareholder; Self; Eli Lilly and Company. C. Benson: Employee; Self; Eli Lilly and Company. C. Loghin: Employee; Self; Eli Lilly and Company. Funding Eli Lilly and Company
Accurate Angular Inference for 802.11ad Devices Using Beam-Specific Measurements (2020)

Due to their sparsity, 60GHz channels are characterized by a few dominant paths. Knowing the angular information of their dominant paths, we can develop various applications, such as the prediction of link performance and the tracking of 802.11ad devices. Although they are equipped with phased arrays, the angular inference for 802.11ad devices is still challenging due to their limited number of RF chains and limited phase control capabilities. Considering the beam sweeping operation and the high communication bandwidth of 802.11ad devices, we propose variation-based angle estimation (VAE), called <monospace xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VAE-CIR</monospace> , by utilizing beam-specific channel impulse responses (CIRs) measured under different beams and the directional gains of the corresponding beams to infer the angular information of dominant paths. Unlike state-of-the-arts, <monospace xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VAE-CIR</monospace> exploits the variations between different beam-specific CIRs for angular inference and provides a performance guarantee in the high signal-to-noise-ratio regime. To evaluate <monospace xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VAE-CIR</monospace> , we generate the beam-specific CIRs by simulating the beam sweeping of 802.11ad devices with the beam patterns measured on off-the-shelf 802.11ad devices. The 60GHz channel is generated via a ray-tracing-based simulator and the CIRs are extracted via channel estimation based on Golay sequences. Through extensive experiments, <monospace xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VAE-CIR</monospace> is shown to achieve more accurate angle estimation than existing schemes.
GazeStereo3D (2016)

Producing a high quality stereoscopic impression on current displays is a challenging task. The content has to be carefully prepared in order to maintain visual comfort, which typically affects the quality of depth reproduction. In this work, we show that this problem can be significantly alleviated when the eye fixation regions can be roughly estimated. We propose a new method for stereoscopic depth adjustment that utilizes eye tracking or other gaze prediction information. The key idea that distinguishes our approach from the previous work is to apply gradual depth adjustments at the eye fixation stage, so that they remain unnoticeable. To this end, we measure the limits imposed on the speed of disparity changes in various depth adjustment scenarios, and formulate a new model that can guide such seamless stereoscopic content processing. Based on this model, we propose a real-time controller that applies local manipulations to stereoscopic content to find the optimum between depth reproduction and visual comfort. We show that the controller is mostly immune to the limitations of low-cost eye tracking solutions. We also demonstrate benefits of our model in off-line applications, such as stereoscopic movie production, where skillful directors can reliably guide and predict viewers' attention or where attended image regions are identified during eye tracking sessions. We validate both our model and the controller in a series of user experiments. They show significant improvements in depth perception without sacrificing the visual quality when our techniques are applied.
Combining surface plasmon resonance and mass spectrometry to identify Bone Morphogenetic Protein (BMP) interactant (2014)

National audience
Activity of Murine Raphe Magnus Cells Predicts Tachypnea and On-Going Nociceptive Responsiveness (2007)

In rats, opioids produce analgesia in large part by their effects on two cell populations in the medullary raphe magnus (RM). To extend our mechanistic understanding of opioid analgesia to the genetically tractable mouse, we characterized behavioral reactions and RM neural responses to opioid administration. d-Ala(2), N-Me-Phe(4)-Gly(5)ol-enkephalin, a mu-opioid receptor agonist, microinjected into the murine RM produced cardiorespiratory depression and reduced slow wave electroencephalographic activity as well as increased the noxious heat-evoked withdrawal latencies. As in rat, RM cell types that were excited and inhibited by noxious stimuli, termed on and off cells, respectively, were observed in mice. However, in contrast to findings in rat, opioid doses that suppressed withdrawals did not alter the background discharge rate of murine on and off cells, suggesting that the cellular mechanisms by which the murine RM generates opioid analgesia are substantially different from those in rats. Murine on cell discharge did not predict the latency or magnitude of an ensuing withdrawal but did correlate to the magnitude and latency of concurrent withdrawals. Although opioids failed to alter the background discharge of on and off cells, they reduced the responses of RM neurons to noxious stimulation, further evidence that RM modulates on-going withdrawals. In characterizing the role of RM in respiratory modulation, we found that on cells burst and off cells paused during tachypneic events. The effects of opioids in the murine RM on homeostasis and the association of on and off cell discharge with tachypnea corroborate roles for opioid signaling in RM beyond analgesia.
Computer analysis of MR images of human knee joints to measure femoral cartilage thickness (2002)

The thickness of articular cartilage can be an important parameter to assess the progression of osteoarthritis. Although Magnetic Resonance Imaging (MRI) can directly visualise cartilage, so far subjective measurement and poor reproducibility have been major problems in the quantitative estimation of cartilage thickness. The ability of MR contrast to visualise cartilage, and an objective assessment using a computerised edge detection technique have now been combined together to give a fully automatic measurement of femoral cartilage thickness for the human knee joint.
O4‐01–05: Presenilin 1 mutation promotes Tau phosphorylation and aggregation in a novel Alzheimer's disease mouse model (2008)

Mutations in the presenilin-1 (PS1) gene increase Aβ production but their effect on tau expression, phosphorylation and/or aggregation has not been thoroughly assessed. Interestingly, patients with PS1 mutations have numerous NFTs suggesting that these mutations sensitize neurons to develop NFTs. An increase in tau phosphorylation has been observed in cells co-transfected with tau and mutant PS1. Also, a complex of PS1, tau and GSK-3β has been observed in human brain. This interaction may regulate tau phosphorylation because GSK-3β has been shown to phosphorylate tau. To investigate the effect of PS1 mutation on tau in vivo, we previously generated a double transgenic model expressing one isoform of wild-type human tau (ON3R) and a mutant form of PS1 (M146L), as well as a triple model that also expresses the Swedish and London mutations in the amyloid precursor protein. The tau pathology in neither models differed from mice expressing only the human ON3R tau isoform (Boutajangout A. et al., Neurobiol. Disease, 15, 47–60, 2004). To further investigate the potential effect of pathogenic PS1 mutation on tangle formation, we crossed htau mice, that express all 6 human isoforms of tau, with PS1 (M146L) mice. These animals were maintained on a mouse tau knockout background (htau/PS1/mtau-/-). Controls were htau/mtau-/- littermates. The mice were killed at 8–9 months for brain analysis. Levels of total tau did not differ between the groups but PHF1 immunoreactive (IR) soluble tau was increased by 126% (p=0.02) in the htau/PS1/mtau-/- mice (n=8) compared to their htau/mtau-/- littermates (n=10). Likewise, immunohistochemical analysis revealed an 84% increase in PHF1 IR tau in the pyriform cortex (p=0.02). Analysis of other brain regions, with other tau antibodies as well as of insoluble tau is underway. Furthermore, tau-related pathology and different ages of animals are being assessed. These findings indicate that the M146L PS1 mutation promotes tau phosphorylation and aggregation, suggesting that PS1/tau interaction may be important in the etiology and/or pathogenesis of AD. This novel model can be very useful for studying the onset and progression of AD as well as for therapeutic studies.
Twist exome capture allows for lower average sequence coverage in clinical exome sequencing (2023)

We conclude that exome sequencing with Twist represents a significant improvement and could be performed at lower sequence coverage compared to other exome capture techniques.
ANACONDA: Robust Synthesis of Analog Circuits via Stochastic Pattern Search (2007)

Analog synthesis tools have traditionally traded quality for speed, substituting simplified circuit evaluation methods for full simulation in order to accelerate the numerical search for solution candidates. In this paper we develop a new numerical search algorithm efficient enough to allow full circuit simulation of each circuit candidate, and robust enough to find good solutions for difficult circuits. Comparison of synthesized circuits against manual industrial designs demonstrates the utility of the approach. I. INTRODUCTION A significant number of system-on-chip (SoC) designs are mixed-signal designs because of the need to interface a digital computational core to the real world. The rapidly increasing scale of SoC designs is stressing existing tools and methodologies; nevertheless the digital portions of these designs rely heavily on synthesis tools. This is not true for the analog portions, which are still routinely designed by hand. This lack of automation has always been a p...
Optimizing Electronic Structure Simulations on a Trapped-ion Quantum Computer using Problem Decomposition (2021)

Quantum computers have the potential to advance material design and drug discovery by performing costly electronic structure calculations. A critical aspect of this application requires optimizing the limited resources of the quantum hardware. Here, we experimentally demonstrate an end-to-end pipeline that focuses on minimizing quantum resources while maintaining accuracy. Using density matrix embedding theory as a problem decomposition technique, and an ion-trap quantum computer, we simulate a ring of 10 hydrogen atoms without freezing any electrons. The originally 20-qubit system is decomposed into 10 two-qubit problems, making it amenable to currently available hardware. Combining this decomposition with a qubit coupled cluster circuit ansatz, circuit optimization, and density matrix purification, we accurately reproduce the potential energy curve in agreement with the full configuration interaction energy in the minimal basis set. Our experimental results are an early demonstration of the potential for problem decomposition to accurately simulate large molecules on quantum hardware.
Supplementary Figure 3 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer (2023)

&lt;p&gt;PDF file - 1652K, Analysis of associations between STC1 expression and stroma abundance and survival.&lt;/p&gt;
Polymer Supported Carbon for Safe and Effective Remediation of PFOA- and PFOS-Contaminated Water (2019)

Powdered activated carbon (PAC) is an economical sorbent for removing micropollutants from water, but it generates hazardous dust that is flammable and a respiration hazard. Additionally, the fine particles of PAC can cake and block filters and membranes, complicating its use in continuous processes. In this study, we present a sulfur polymer support for PAC that overcomes these problems. The blend of the sulfur polymer and PAC generates low dust and it does not block filters. The utility of the sorbent is demonstrated in the remediation of water contaminated with perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), persistent micropollutants that currently threaten water safety worldwide. Fundamental discoveries of PFOA self-assembly are also reported, as well as testing on a field sample of contaminated surface water.
Optimizing Bifacial Silicon Heterojunction Solar Cells for High-Latitudes (2019)

Two-dimensional optoelectronic modelling of bifacial silicon heterojunction solar cells is completed in Synopsys TCAD Sentaurus to optimize and characterize cell performance for regions of high latitude where cells experience high average air mass and increased angles of incidence. Cell performance under bifacial illumination conditions representative of the Canadian High Arctic, with independent spectra illuminating the front and rear faces of the cell, is studied. The baseline cell structure has an efficiency of 20.4% and 19.3% under front-face illumination with AM1.5G and AM3.0G, respectively. Improvements will be made through the addition of surface texturing and the optimization of doping, layer thicknesses, and antireflection coatings.
Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces (2014)

Although the thrombogenic nature of the surfaces of cardiovascular devices is an important aspect of blood biocompatibility, few studies have examined platelet deposition onto opaque materials used for these devices in real time. This is particularly true for the metallic surfaces used in current ventricular assist devices (VADs). Using hemoglobin depleted red blood cells (RBC ghosts) and long working distance optics to visualize platelet deposition, we sought to perform such an evaluation. Fluorescently labeled platelets mixed with human RBC ghosts were perfused across six opaque materials (a titanium alloy (Ti6Al4V), silicon carbide (SiC), alumina (Al2O3, 2-methacryloyloxyethyl phosphorylcholine polymer coated Ti6Al4V (MPC-Ti6Al4V), yttria partially stabilized zirconia (YZTP), and zirconia toughened alumina (ZTA)) for 5 min at wall shear rates of 400 and 1000 s(-1). Ti6Al4V had significantly increased platelet deposition relative to MPC-Ti6Al4V, Al2 O3 , YZTP, and ZTA at both wall shear rates (p < 0.01). For all test surfaces, increasing the wall shear rate produced a trend of decreased platelet adhesion. The described system can be a utilized as a tool for comparative analysis of candidate blood-contacting materials with acute blood contact.
Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae (1989)

The metabolism of polyphosphoinositides has been shown to be an important factor in controlling the proliferation of Saccharomyces cerevisiae. The monophosphate form of phosphatidylinositol has been assumed to be phosphatidylinositol 4-phosphate (PI-4-P). Recent evidence from our laboratory has established that a phosphatidylinositol (PI) kinase, which phosphorylates the D-3 position of the inositol ring (PI 3-kinase), is associated with many activated protein-tyrosine kinases and may play an important role in the signaling of cell proliferation (Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P., and Cantley, L. C. (1989) Cell 57, 167-175). To determine the evolutionary conservation of this enzymatic activity, we investigated its presence in yeast. In vitro PI kinase assays of yeast cell homogenates demonstrated that PI 3-kinase activity was present. Preliminary biochemical characterization of the activity suggested that it was quite different from the mammalian enzyme yet catalyzed the same reaction, i.e. phosphorylating the D-3 hydroxyl position of the inositol ring of phosphatidyl-myo-inositol. [3H]Inositol labeling of intact yeast cells with the subsequent extraction, deacylation, and high performance liquid chromatography analysis of the lipids demonstrated that PI-3-P was as abundant as the PI-4-P isomer. The conservation of the enzymatic activity from yeast to man suggests that it has an important functional role in the cell cycle.
Numerical Simulation of GM Refrigerator Operating at about 4K. (1998)

This paper describes the numerical simulation of a GM refrigerator operating at about 4K. The simulation model is composed of a regenerator, an expansion space, and a cooling stage. The volumetric change of the expansion space and the actual thermophysical properties of the working fluid, helium are considered. The basic equations are made up of one-dimensional fluid equations and an energy equation of the regenerator material and the cooling stage. The fluid equations are expressed in the general coordinate system of which a coordinate axis moves with time to take account of the volumetric change of the expansion space. These basic equations are differentiated by using the TVD MacCormack method. In order to verify the simulation model, the theoretical validity of the calculation results was checked and calculation results were compared with results of experiments. As a result it was confirmed that the simulation model is appropriate.
Enhanced-efficiency front-end module with multi-standard impedance-tunable antenna (2012)

Energy-efficiency is of paramount importance in modern battery-powered wireless communication devices in order to provide longer talk-time and autonomy. At the radio level, the power amplifier is a major contributor to the power consumption, especially with recent non-constant envelope modulations requiring stringent linearity. Another energy efficiency issue arises at the antenna level in miniature handheld terminals, since the antenna impedance variations may result in significant reflection losses and require the PA to operate at maximum output power. This article presents the development of a front-end module composed of a PA with envelope-tracking system operating at 1920-1980 MHz and a multi-standard miniature antenna associated to an integrated automatic impedance tuner.
New approaches for designing microstrip filters utilizing mixed dielectrics (2005)

A strategy is developed for designing capacitively loaded microstrip filters on low-temperature co-fired ceramic (LTCC) substrates with inclusions or superstrate layers of higher permittivity dielectrics. Finite-difference time-domain simulations of the field distribution at resonant frequencies are used to determine the optimal locations and size of capacitive loads. It is demonstrated that strategic capacitive load placement enables altering the center and attenuation pole frequencies, the shape and width of the passband, and input impedance of the filter by modification of selected resonant modes. Capacitive loading with higher permittivity dielectrics is shown to be very efficient in decreasing dimensions of microstrip filters with low-permittivity substrates. The designs of novel compact resonators and filters have been developed and the prototypes fabricated by using LTCC technology. The results of prototype measurements agree with the simulation results, which validates the proposed approach
ChemInform Abstract: Cationic Ring Expansion of an Ozonide to a 1,2,4‐Trioxane. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
(De) focusing on global light transport for active scene recovery (2009)

Most active scene recovery techniques assume that a scene point is illuminated only directly by the illumination source. Consequently, global illumination effects due to inter-reflections, sub-surface scattering and volumetric scattering introduce strong biases in the recovered scene shape. Our goal is to recover scene properties in the presence of global illumination. To this end, we study the interplay between global illumination and the depth cue of illumination defocus. By expressing both these effects as low pass filters, we derive an approximate invariant that can be used to separate them without explicitly modeling the light transport. This is directly useful in any scenario where limited depth-of-field devices (such as projectors) are used to illuminate scenes with global light transport and significant depth variations. We show two applications: (a) accurate depth recovery in the presence of global illumination, and (b) factoring out the effects of defocus for correct direct-global separation in large depth scenes. We demonstrate our approach using scenes with complex shapes, reflectances, textures and translucencies.