gebhart/patrepeval huggingface dataset:
The stability of one-dimensional inverse scattering (1994)

The stability of one-dimensional inverse scattering is discussed. The analysis is performed analytically using perturbation theory for reflection coefficients that are rational functions of the wavenumber and numerically for realistic reflection coefficients. It is shown that the same instability features occur for real reflections as for rational reflection coefficients. There are three types of error considered which are common in the application of the data. Explicitly examined are an erroneously chosen DC level, an amplitude error and a time error. It is shown that the physical reason for the instabilities of the one-dimensional inverse problem is the lack of sufficient energy penetration in the potential that is examined.
Bang for the buck: Improvising and scheduling verification engines for effective resource utilization (2009)

In practice, verification engines have to solve many checkers in a very tight time budget, especially, when the system to be analyzed is large, with many coverage criteria. To cope with such a situation, we propose improved and light-weight verification techniques that are built over the state-of-the-art engines such as bounded model checking (BMC), induction, and guided-simulation (directed testing). Specifically, we propose using control state reachability (CSR) information—obtained from a given software system—to strengthen our induction-based proof engine. We also propose identifying and using lighthouses (or guide-posts)—intermediate control states—to simplify and reduce BMC instances, and to guide a simulation engine. We schedule these engines suitably to maximize the resource utilization. We implemented our techniques in a tool ACE, and integrated it in an industry strength software verification platform F-Soft to provide a robust and precise analysis framework. We show effectiveness of ACE on several industry and public benchmarks in a comparative study.
Transformation of Primary Amines to N ‐Monoalkylhydroxylamines: N ‐Hydroxy‐( S )‐1‐Phenylethylamine Oxalate (2003)

Abstract (S)‐1‐Phenylethylamine Diisopropylethylamine Bromoacetonitrile (S)‐[1‐Phenylethyl]imino]acetonitrile N‐oxide Hydroxylamine hydrochloride Oxalic acid N‐Hydroxy‐(S)‐1‐phenylethylamine oxalate
Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp. (2015)

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.
Localization and Expression of Cartilage Oligomeric Matrix Protein by Human Rheumatoid and Osteoarthritic Synovium and Cartilage (1999)

Synovium and cartilage from patients with osteoarthritis or rheumatoid arthritis were analyzed for expression of cartilage oligomeric matrix protein. Immunostaining of synovium with antiserum to cartilage oligomeric matrix protein demonstrated positive staining in both diseases. In osteoarthritis, there was positive staining within the synovial cells and immediately subjacent connective tissue, with less intense staining in the deeper connective tissue. In rheumatoid arthritis, there was less intense staining within the synovial cells and marked intense staining in the deeper connective tissue. In situ hybridization performed with an antisense digoxigenin-labeled riboprobe to human cartilage oligomeric matrix protein confirmed the presence of cartilage oligomeric matrix protein mRNA in the cells of the synovial lining in both types of synovium. Quantitative polymerase chain reaction with a cartilage oligomeric matrix protein MIMIC demonstrated increased cartilage oligomeric matrix protein mRNA in rheumatoid cartilage and synovium as compared with osteoarthritic cartilage and synovium, respectively; mRNA levels in rheumatoid synovium were similar to those from osteoarthritic chondrocytes. As a result of the high expression of cartilage oligomeric matrix protein from rheumatoid synovium, inflammatory synovium should be considered as a potential tissue source of cartilage oligomeric matrix protein in any investigation of biological markers of cartilage metabolism. The upregulated expression of cartilage oligomeric matrix protein in inflammatory tissues suggests its in vivo regulation by cytokines.
Livrable D4.2 of the PERSEE project : Représentation et codage 3D - Rapport intermédiaire - Définitions des softs et architecture (2011)

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Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts (1989)

Ascorbic acid stimulates collagen gene expression in cultural fibroblasts (Lyons, B. L., and Schwartz, R. L. (1984) Nucleic Acids Res. 12, 2569-2579), but the mechanisms responsible for this effect are poorly understood. In the presence of the transitional metal iron, ascorbic acid could induce lipid peroxidation with the formation of reactive aldehydes. Since another aldehyde, acetaldehyde, the first metabolite of ethanol, also stimulates collagen transcription in cultured fibroblasts (Brenner, D. A., and Chojkier, M. (1987) J. Biol. Chem 262, 17690-17696), we investigated whether ascorbic acid induces lipid peroxidation in cultured cells and if this is the mechanism by which ascorbic acid stimulates collagen gene expression. Ascorbic acid (0.2 mM) induced lipid peroxidation in cultured human fibroblasts judging by the production of thiobarbituric acid-reactive substances and carbonyl groups, and by the presence of malondialdehyde- and 4-hydroxynonenal-protein adducts. Ascorbic acid stimulated (2-3-fold) the net production of collagen relative to total proteins, the levels of procollagen alpha 1 (I) mRNA and the transcription of this gene. Inhibition of the ascorbic acid-induced lipid peroxidation in cultured human fibroblasts with alpha-tocopherol (50 microM) or methylene blue (10 microM) prevented the stimulation of collagen gene expression. The addition of malondialdehyde (200 microM), a product of lipid peroxidation, to cultured human fibroblasts also increased 2-3-fold collagen production and procollagen alpha 1 (I) mRNA levels. Thus, ascorbic acid induces lipid peroxidation and reactive aldehydes and this step may be necessary for the stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts.
BILATERAL INTRAVITREAL INJECTION OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY (2010)

Bilateral injections of antivascular endothelial growth factor agents on the same day did not increase the rate of adverse events and was preferred by the majority of patients.
CCDC 1508585: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Table S1 from Characterization of the Anti–PD-1 Antibody REGN2810 and Its Antitumor Activity in Human <i>PD-1</i> Knock-In Mice (2023)

&lt;p&gt;Measuring binding kinetics of human and mouse PD-1/PD-L1 interactions using surface plasmon resonance.&lt;/p&gt;
<title>Field evaluation of acoustic-wave chemical sensors for monitoring of organic solvents in groundwater</title> (1999)

An instrument for in-situ monitoring of volatile organics in groundwater at pat-per-billion levels has been developed and field tested. The device is an acoustic wave thickness-shear mode sensor based on a 10-MHa AT-cut quartz resonator coated with a non-polar polymer film. The sensor demonstrates a detection limit of 8 and 12 parts per billion in water for trichloroethylene and toluene, respectively, and a rapid reversible response. This low detection limit is achieved by carefully minimizing the noise level in the electronic detection system, by optimizing the thickness of the sensing polymer film, and by performing measurements in the headspace. Preliminary field test demonstrated good correlation of sensor response with conventional laboratory purge-and-trap/GC analysis.
HOE 694 Blocks Na<sup>+</sup>/H<sup>+</sup> Exchange in Human B Lymphoblasts without Influencing Proliferation (1995)

The effect of HOE 694 (3-methylsulfonyl-4-piperidinobenzoyl guanidine hydrochloride), a novel inhibitor of Na+/H+ exchange, on pHi recovery from acidification and on proliferation of human B lymphoblasts was investigated. HOE 694 inhibited the Na+/H+ exchanger in a concentration-dependent manner. Inhibition constants (Ki) were calculated at 89 ± 5 and 54 ± 7 nmol/l (means ± SD; n = 5) at 135 and 79 mmol/l external Na+, respectively. This indicates a competition of HOE 694 with external Na+ ions at a common binding site of the Na+/H+ exchanger. Subsequently, the effects of HOE 694 upon DNA synthesis and proliferation of lymphoblasts were examined. HOE 694 inhibited cell proliferation and DNA synthesis only at concentrations of > 10 µmol/l. This suggests that in the presence of bicarbonate a functionally active Na+/ H+ exchanger is not required for the proliferation of B lymphoblasts.
Identification of Tumor-Specific Antibodies in Patients With Breast Cancer Vaccinated With Gene-Modified Allogeneic Tumor Cells (2003)

Thirty HLA-A2 women with metastatic breast cancer received up to 14 vaccinations with MDA-MB-231-CD80, an HLA-A2 allogeneic breast cancer cell line, which had been lipofected with the cDNA for the CD80 costimulatory molecule. Tumor cells were administered with BCG or GM-CSF as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to tumor cell lysate, MUC1, HER2/neu and p53. Since the cell line was grown in fetal bovine serum (FBS), sera were also analyzed for antibodies to FBS. Eighteen of 24 patients for whom sera were available exhibited anti-FBS activity at baseline. Eleven of these 18 patients and all six patients without baseline anti-FBS activity showed an increased titer after vaccination. The anti-FBS activity required that serum samples be absorbed in excess FBS to detect specific antibodies to tumor cell lysate. A two-fold increase in the titer of IgG specific to tumor cell lysate was observed in 6 patients. Eight of 24 patients made an antibody response to HER-2/neu, four of 24 to MUC1 and one of 24 to p53. Although antibody production to a variety of tumor cell-associated antigens was detected our results suggest that a whole cell vaccine comprising a CD80-transfected allogeneic breast cancer cell line with adjuvant BCG or GM-CSF was not a reliable method to induce significant antibody responses in women with advanced breast cancer.
Newspaper City: Toronto’s Street Surfaces and the Liberal Press, 1860–1935 by Phillip Gordon Mackintosh (2019)

"Newspaper City: Toronto’s Street Surfaces and the Liberal Press, 1860–1935 by Phillip Gordon Mackintosh." University of Toronto Quarterly, 88(3), pp. 144–146
Protein Farnesyltransferase from Trypanosoma brucei (1998)

We have previously shown that protein prenylation occurs in the Trypanosomatids Trypanosoma brucei (T. brucei), Trypanosoma cruzi, and Leishmania mexicana and that protein farnesyltransferase (PFT) activity can be detected in cytosolic extracts of insect (procyclic) form T. brucei. A PFT that transfers the farnesyl group from farnesyl pyrophosphate to a cysteine that is 4 residues upstream of the C terminus of the Ras GTP-binding protein RAS1-CVIM has now been purified 60,000-fold to near homogeneity from procyclic T. brucei. By screening a mixture of hexapeptides SSCALX (X is 20 different amino acids), it was found that SSCALM binds to T. brucei PFT with sub-micromolar affinity, and affinity chromatography using this peptide was a key step in the purification of this enzyme. On SDS-polyacrylamide gel electrophoresis, the enzyme migrates as a pair of bands with apparent molecular masses of 61 and 65 kDa, and thus its subunits are approximately 30% larger than those of the mammalian homolog. The 61-kDa band was identified as the putative beta-subunit by photoaffinity labeling with a 32P-labeled analog of farnesyl pyrophosphate. Mimetics of the C-terminal tetrapeptide of prenyl acceptors have been previously shown to inhibit mammalian PFT, and these compounds also inhibit T. brucei PFT with affinities in the nanomolar to micromolar range, although the structure-activity relationship is very different for parasite versus mammalian enzyme. Unlike mammalian cells, the growth of bloodstream T. brucei is completely inhibited by low micromolar concentrations of two of the PFT inhibitors, and these compounds also block protein farnesylation in cultured parasites. These compounds also potently block the growth of the intracellular (amastigote) form of T. cruzi grown in fibroblast host cells. The results suggest that protein farnesylation is a target for the development of anti-trypanosomatid chemotherapeutics.
Cyclic Tetramers of Zinc Chlorophylls as a Coupled Light‐Harvesting Antenna–Charge‐Separation System (2015)

A coupled light-harvesting antenna-charge-separation system, consisting of self-assembled zinc chlorophyll derivatives that incorporate an electron-accepting unit, is reported. The cyclic tetramers that incorporated an electron acceptor were constructed by the co-assembly of a pyridine-appended zinc chlorophyll derivative, ZnPy, and a zinc chlorophyll derivative further decorated with a fullerene unit, ZnPyC60 . Comprehensive steady-state and time-resolved spectroscopic studies were conducted for the individual tetramers of ZnPy and ZnPyC60 as well as their co-tetramers. Intra-assembly singlet energy transfer was confirmed by singlet-singlet annihilation in the ZnPy tetramer. Electron transfer from the singlet chlorin unit to the fullerene unit was clearly demonstrated by the transient absorption of the fullerene radical anion in the ZnPyC60 tetramer. Finally, with the co-tetramer, a coupled light-harvesting and charge-separation system with practically 100 % quantum efficiency was demonstrated.
ChemInform Abstract: Useful Chemistry of 3‐(1‐Methylethylidene)‐4‐acetoxy‐2‐azetidinone: A Formal Synthesis of (±)‐Asparenomycin C. (1986)

Abstract Die im nachfolgenden beschriebenen Umsetzungen werden im Hinblick auf eine formale Synthese von (±)‐Asparenomycin C (XXII) durchgeführt.
PULSED ELECTRON AVALANCHE KNIFE IN VITREORETINAL SURGERY (2005)

PEAK-fc offers precise and tractionless tissue cutting during ocular surgery. Using different waveform parameters, the same device performs cold cutting and/or "hot" coagulation, thus improving the precision, safety, and ergonomics of vitreoretinal surgery.
Effects of effective reaction radius for neutralization on performance of chemically amplified resists (2014)

A basic compound called a quencher plays an important role in the control of the acid catalytic chain reaction in chemically amplified resists used for the high-volume production of semiconductor devices. In this study, the effects of the effective reaction radius for the neutralization between acids and quenchers on the quality of latent images formed in chemically amplified resists were investigated assuming line-and-space patterns with a half-pitch of 16 nm. It was found that the efficiency of the termination of chain reactions strongly affects the performance (not only resolution but also sensitivity and line edge roughness) of a resist that utilizes the chemical amplification mechanism. The high performance of chemically amplified resists is linked to the high efficiency of acid-base neutralization.
Circulating adrenomedullin in cirrhosis (1998)

Fernández-Rodriguez, Conrado M.; Prada, Ignacio R.; Prieto, Jesüs; Montuenga, Luis M.; Elssasser, Ted; Quiroga, Jorge; Moreiras, Mercedes; Andrade, Amalia; Cuttitta, Frank
A Hybrid Technique for Laser Flare Reduction (2016)

A hybrid approach to near-wall measurements with laser-based velocimetry techniques utilizing light transmission and fluorescence is presented. This method aims to minimize the effect of contamination by laser flare light, and has application to facilities where optimal configurations are not achievable. The basis of the approach is to replace the solid surface near which measurements are desired with a transparent solid material treated with a fluorescent surface coating. Further discussion is provided on the optimal placement of cameras. Measurements are made of the flow field around the trailing edge of a model DU96-W-180 wind turbine blade in a 0.7 m square cross-section Open Jet Wind Tunnel using Particle Image Velocimetry in a configuration optimized for minimum flare. For the wind turbine blade model, measurements were obtained 0.4 mm from the surface using the comprehensive approach. Benchtop measurements representative of a non-optimal configuration are made to demonstrate a more practical application of the transparent material / fluorescent treatment technique.
High efficiency Indirect Matrix Converter topologies (2013)

This paper discusses new three-phase ac-ac Indirect Matrix Converter (IMC) topologies featuring higher power efficiency than conventional IMCs. Initially, a new Inverting-link Matrix Converter (ILMC) with lower conduction power losses than a standard ILMC for voltage step-down operation is proposed. New Ultra-Sparse Matrix Converters (USMCs) well-suited for voltage step-down applications are also presented. These circuits have redundant current paths to distribute the impressed dc-link current to the input terminals which can be potentially used to reduce semiconductor losses. A voltage step-up USMC, referred to as delta-switch USMC (Δ-USMC), well-suited for wind power generation systems, where low inductance machines are used, is also analyzed. In order to benefit from the best features of the proposed IMCs, standard and new space vector modulations featuring distinctive commutation schemes are presented. Finally, to demonstrate the advantages of the studied IMCs, power loss comparisons of these solutions and standard IMCs rated to 10 kW are shown.
Joint compensation of CFO and IQ imbalance for 4G Wireless Systems (2006)

info:eu-repo/semantics/published
Diode snappiness from a user's perspective (2015)

This paper deals with reverse recovery and snappiness in high voltage PiN diodes as the ones currently used in high power electronics applications. It suggests a practical quantitative definition for the occurrence of snappiness and investigates unusual phenomena that might occur during reverse recovery.
Cloning and characterization of the major outer membrane protein gene (ompH) of Pasteurella multocida X-73 (1997)

The major outer membrane protein (OmpH) of Pasteurella multocida X-73 was purified by selective extraction with detergents, followed by size exclusion chromatography. The planar lipid bilayer assay showed that OmpH has pore-forming function. The average single channel conductance in 1.0 M KCl was 0.62 nS. The gene (ompH) encoding OmpH has been isolated and sequenced by construction of a genomic library and PCR techniques. The coding region of this gene is 1,059 bp long. The predicted primary protein is composed of 353 amino acids, with a 20-amino-acid signal peptide. The mature protein is composed of 333 amino acids with a molecular mass of 36.665 kDa. The ompH gene encoding mature protein has been expressed in Escherichia coli by using a regulatable expression system. The ompH gene was distributed among 15 P. multocida serotypes and strain CU. Protection studies showed that OmpH was able to induce homologous protection in chickens. These findings demonstrate that OmpH is a protective outer membrane porin of strain X-73 and is conserved among P. multocida somatic serotypes.
Reduced Impact of Frequency Dithering on the Performance of High-Order Modulation Format Phase Conjugation (2021)

We address the primary degradations in optical phase conjugation devices, reducing the implementation penalty to below 0.2dB and enabling, for the first time, performance improvement in a 400-km long probabilistically shaped 256-QAM transmission system.
Dewetting and Layer Inversion of Inverted PVP/PS Bilayer Films (2003)

This work was supported by the National Research Laboratory fund (Grant M1-0104-00-0191) from the Ministry of Science and&#13;\nTechnology (MOST), the Ministry of Education through the Brain Korea 21 Program at Seoul National University, and the National R&amp;D Project for Nano Science and Technology from MOST.
FootNotes (2018)

The majority of information in the physical environment is conveyed visually, meaning that people with vision impairments often lack access to the shared cultural, historical, and practical features that define a city. How can someone who is blind find out about the sleek skyscrapers that dot a modern city's skyline, historic cannons that have been remade into traffic pillars, or ancient trees that uproot a neighborhood's sidewalks? We present FootNotes, a system that embeds rich textual descriptions of objects and locations in OpenStreetMap, a popular geowiki. Both sighted and blind users can annotate the physical environment with functional, visual, historical, and social descriptions. We report on the experience of ten participants with vision impairments who used a spatialized audio application to interact with these annotations while exploring a city. By sharing rich annotations of physical objects and areas, FootNotes helps people thoroughly explore a new location or serendipitously discover previously unknown features of familiar environments.
Silver-Colloid-Nucleated Cytochrome c Superstructures Encapsulated in Silica Nanoarchitectures (2004)

We recently discovered that self-organized superstructures of the heme protein cytochrome c (cyt. c) are nucleated in buffer by gold nanoparticles. The protein molecules within the superstructure survive both silica sol-gel encapsulation and drying from supercritical carbon dioxide to form air-filled biocomposite aerogels that exhibit gas-phase binding activity for nitric oxide. In this investigation, we report that viable proteins are present in biocomposite aerogels when the nucleating metal nanoparticle is silver rather than gold. Silver colloids were synthesized via reduction of an aqueous solution of Ag+ using either citrate or borohydride reductants. As determined by transmission electron microscopy and UV-visible absorption spectroscopy, the silver nanoparticles vary in size and shape depending on the synthetic route, which affects the fraction of cyt. c that survives the processing necessary to form a biocomposite aerogel. Silver colloids synthesized via the citrate preparation are polydisperse, with sizes ranging from 1 to 100 nm, and lead to low cyt. c viability in the dried bioaerogels (approximately 15%). Protein superstructures nucleated at approximately 10-nm Ag colloids prepared via the borohydride route, including citrate stabilization of the borohydride-reduced metal, retain significant protein viability within the bioaerogels (approximately 45%).
Seamless Integration of Dose‐Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of β‐Secretase (BACE1) Inhibitors (2014)

Drug discovery is a multifaceted endeavor encompassing as its core element the generation of structure-activity relationship (SAR) data by repeated chemical synthesis and biological testing of tailored molecules. Herein, we report on the development of a flow-based biochemical assay and its seamless integration into a fully automated system comprising flow chemical synthesis, purification and in-line quantification of compound concentration. This novel synthesis-screening platform enables to obtain SAR data on b-secretase (BACE1) inhibitors at an unprecedented cycle time of only 1 h instead of several days. Full integration and automation of industrial processes have always led to productivity gains and cost reductions, and this work demonstrates how applying these concepts to SAR generation may lead to a more efficient drug discovery process.