gebhart/patrepeval huggingface dataset:
Theoretical Considerations on the Impact of Nearby Tags on the Wireless Power Transfer From the Reader to the Target Tag in Passive UHF RFID (2023)

Radio frequency identification (RFID) technology, and in particular the passive UHF (ultra-high frequencies) standard, is developing strongly with the emergence of cognitive sensor networks and especially the Internet-of-Things. A significant indicator of this evolution is that tags are increasingly equipped with new capabilities: in addition to the identification functionality, there are, for example, those of sensor or actuator. In this context, the energy requirement at the tag level, known as augmented tag, is clearly increasing. Consequently, on the one hand, reading distances can be limited (the energy received is shared between the different components of the augmented tag) and on the other hand, to overcome the problem, semi-passive solutions (on-board battery to power the active electronic circuits) are proposed at the expense of the decisive advantage of the passive nature of the tags. It is therefore necessary to find alternative solutions to optimize the energy transfer between the reader and the tags. The concept proposed here is to target a particular tag, the one being queried, and to exploit the tags in its vicinity as reflectors in order to converge a maximum of power transmitted by the reader on the “target” tag. The paper uses an adapted mathematical formalism to evaluate the total power that can be received by a target tag as a function of the tags in its neighborhood: the impact of their relative position and of the load impedance of the reflector tags is analyzed and illustrated by simulations.
The bactericidal effect of oral care using matching transformation system: A prospective clinical study (2022)

Abstract Aim Matching transformation system (MA‐T) is an on‐demand aqueous chlorine dioxide solution that realizes excellent safety with various antimicrobial activities even under abundant organic compound. By using MA‐T in human oral care, we examined its effectiveness against bacteria causing oral infections such as periodontal disease and dental caries. Materials and Methods The participants of the 75th Annual Meeting of the Japanese Stomatological Society held on May 13 and 14, 2021, were enrolled in this study. Saliva samples were collected on the first day after normal oral care and on the second day after oral care with MA‐T. The total number of bacteria and the numbers of Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola , Streptococcus mutans , and Candida albicans were compared for the two samples on Days 1 and 2. Results Twenty‐two subjects met the study criteria. The total bacterial count and the number of T. forsythia on Day 2 were significantly lower than those on Day 1 ( p = 0.000177 and p = 0.0186, respectively). The numbers of T. denticola and S. mutans tended to decrease, although not significantly ( p = 0.100 and p = 0.251, respectively). Statistical analysis was not performed for P. gingivalis and C. albicans because of sample size. Conclusion MA‐T is putatively effective for oral hygiene. MA‐T oral care reduces bacteria that cause periodontal disease and dental caries compared with regular oral care. The results of this study suggest that MA‐T, a new disinfectant, can be applied to oral care and may reduce periodontal disease, dental caries, and other oral infections.
First-in-human dose escalation and food effect study of oral ONC206 in adults with recurrent primary CNS neoplasms. (2021)

TPS2072 Background: The majority of recurrent CNS tumors lack effective systemic therapy options following surgical resection and adjuvant radiotherapy. ONC201, the founding member of the imipridone class of small molecules, has induced durable tumor regressions in patients with diffuse midline glioma, H3 K27M-mutant (DMG H3K27M). ONC206, the second imipridone to enter clinical development, is a DRD2 antagonist and ClpP agonist that exhibits differentiated receptor pharmacology and gene expression profiles in tumors relative to ONC201. The compound is orally bioavailable, penetrates the blood-brain barrier, and exhibits anti-cancer efficacy without toxicity in several preclinical cancer models with pronounced efficacy in myc-overexpressing CNS tumors. Methods: A first-in-human, open label, dose escalation, and food effect Phase I study of oral ONC206 (NCT04541082) is currently enrolling. Patients must be 18 years or older and diagnosed with a recurrent, primary CNS neoplasm. Eligible diseases include recurrent glioblastoma, WHO Grade 2 and 3 infiltrating glial neoplasms, DMG H3K27M, ependymoma, medulloblastoma, malignant meningiomas, and other rare primary CNS neoplasms. Dose escalation, initially with weekly dosing, will follow a standard 3+3 design. After the MTD is established, a food effect cohort will enroll with a balanced, single-dose, two-arm, two-period, crossover design. The primary endpoint is to determine DLT during the first 28-day cycle. Secondary endpoints will include objective response rate by RANO criteria, overall and progression-free survival, and disease control rate. Exploratory biomarker analyses based on preclinical correlations with efficacy will include DRD2, DRD2 dimer, ClpP, DRD5, c-myc, and n-myc expression. Clinical trial information: NCT04541082.
Two genes encoding ‘minor’ legumin polypeptides in pea (Pisum sativum L.). Characterization and complete sequence of the LegJ gene (1988)

A genomic clone from pea (Pisum sativum L.) contains all of one gene encoding a 'minor' (B-type) legumin polypeptide, and most of a second very similar gene. The two genes, designated LegJ and LegK, are arranged in tandem, separated by approx. 6 kb. A complete sequence of gene LegJ and its flanking sequences is given, with as much of the sequence of gene LegK as is present on the genomic clone. Hybridization of 3' flanking sequence probes to seed mRNA, and sequence comparisons with cDNA species, suggested that gene LegJ, and probably gene LegK, was expressed. The partial amino acid sequences of 'minor' legumin alpha- and beta-polypeptides were used to confirm the identity of these genes. The transciption start in gene LegJ was mapped. The 5' flanking sequence of gene LegJ contains a sequence conserved in legumin genes from pea and other species, which is likely to have functional significance in control of gene expression. Sequence comparisons with legumin genes and cDNA species from Vicia faba and soya bean show that separation of legumin genes into A- and B-type subfamilies occurred before separation of the Viciae and Glycinae tribes.
Performance Analysis of Energy-Efficient Power Allocation for MIMO-MRC Systems (2012)

We formulate an adaptive power allocation problem where we minimize the energy-per-goodbit (EPG) of a system employing a multiple-input multiple-output maximum ratio combining (MIMO-MRC) scheme. Closed-form results are obtained for the optimum transmit power and minimum EPG as a function of the number of antennas employed and the quality of the channel. To assess the performance of the solution in a statistically varying channel, we obtain the cumulative distribution function (CDF) of the minimum EPG in closed form. We explore the energy-efficiency trade-off between enhanced diversity and the increased circuit power consumption of multiple antennas. In particular, we use the EPG CDF in a numerical example to find the most energy-efficient number of antennas for a given probability of outage. We consider both Rayleigh and Rician MIMO fading channels.
Fast compressive lens-free tomography for 3D biological cell culture imaging (2020)

We present a compressive lens-free technique that performs tomographic imaging across a cubic millimeter-scale volume from highly sparse data. Compared with existing lens-free 3D microscopy systems, our method requires an order of magnitude fewer multi-angle illuminations for tomographic reconstruction, leading to a compact, cost-effective and scanning-free setup with a reduced data acquisition time to enable high-throughput 3D imaging of dynamic biological processes. We apply a fast proximal gradient algorithm with composite regularization to address the ill-posed tomographic inverse problem. Using simulated data, we show that the proposed method can achieve a reconstruction speed ∼10× faster than the state-of-the-art inverse problem approach in 3D lens-free microscopy. We experimentally validate the effectiveness of our method by imaging a resolution test chart and polystyrene beads, demonstrating its capability to resolve micron-size features in both lateral and axial directions. Furthermore, tomographic reconstruction results of neuronspheres and intestinal organoids reveal the potential of this 3D imaging technique for high-resolution and high-throughput biological applications.
Metastasis suppressor gene(s) for rat prostate cancer on the long arm of human chromosome 7 (1999)

Allelotype analyses of human prostate cancer indicate that allelic losses on human chromosome arms 7q, 8p, 10q, 13q, 16q, 17q, and 18q are observed frequently. For the study of the possible biological significance of the frequently observed deletions on chromosome arm 7q in human prostate cancer, human chromosome 7 was introduced into highly metastatic rat prostate cancer cells by use of a microcell-mediated chromosome transfer technique. The introduction of human chromosome 7 resulted in the suppression of metastatic ability of the microcell hybrids, whereas no suppression of tumorigenicity was observed. To identify the portion of chromosome 7 containing the metastasis-suppressive function gene, the derivative chromosome 7 that was generated with the initial transfer was retransferred into rat prostate cancer cells. Human chromosome 7-containing rat prostate cancer cells could be used as the donor cells, because rodent cells produced a sufficient number of microcells with colchicine treatment. Cytogenetic and molecular analyses of these clones demonstrated that loss of segments on 7q was related to the reexpression of the metastatic phenotype. These results show that human 7q contains a metastasis suppressor gene or genes for rat prostate cancer. The findings also suggest that this gene may play an important role in the progression of human prostate cancer.
Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans (2020)

Abstract Neural circuits coordinate with muscles and sensory feedback to generate motor behaviors appropriate to an animal’s environment. In C. elegans , the mechanisms by which the motor circuit generates undulations and modulates them based on the environment are largely unclear. We quantitatively analyzed C. elegans locomotion during free movement and during transient optogenetic muscle inhibition. Undulatory movements were highly asymmetrical with respect to the duration of bending and unbending during each cycle. Phase response curves induced by brief optogenetic inhibition of head muscles showed gradual increases and rapid decreases as a function of phase at which the perturbation was applied. A relaxation oscillator model based on proprioceptive thresholds that switch the active muscle moment was developed and is shown to quantitatively agree with data from free movement, phase responses, and previous results for gait adaptation to mechanical loadings. Our results suggest a neuromuscular mechanism underlying C. elegans motor pattern generation within a compact circuit.
Ultrahigh-performance long-focal-length close-focusing zoom lens for the visible waveband (1993)

A long focal length close focusing zoom lens for the visible waveband which rivals the performance of fixed long focal length lenses is described. Particular areas of discussion include, the utilization of anomalous glasses to control secondary color and the choice of focus system configuration to minimize breathing, provide continuous close focusing to macro magnifications and the reduction of the number of large diameter elements required.
Construction report of 6 x 6 rod bundle reflood test facility (ATHER) (2008)

The 6x6 reflood test facility has been constructed by KAERI to quantify rewetting mechanism and evaluate the effect of dispersed flow cooling with respect to droplet behavior. The test section consists of a simulated 6 x 6 rod bundle, a flow housing, 4 pairs of borosilicate glasses for a visual observation and instrumentation. Axial power shape of the simulated heater rod is cosine. Peaking factor and heated length of the rod bundle are 1.468 and 3,810 mm, respectively. Special features of this facility are a separator tank to measure the amount of entrained droplet and a superheated steam probe for the measurement of superheated steam temperature in sub-channel. The experimental results from this study will be useful for the performance evaluation and the program update of the related computer code.
Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3Receptor Inverse Agonist (2011)

Optimization of a novel series of pyridazin-3-one histamine H(3) receptor (H(3)R) antagonists/inverse agonists identified 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (8a, CEP-26401; irdabisant) as a lead candidate for potential use in the treatment of attentional and cognitive disorders. 8a had high affinity for both human (K(i) = 2.0 nM) and rat (K(i) = 7.2 nM) H(3)Rs with greater than 1000-fold selectivity over the hH(1)R, hH(2)R, and hH(4)R histamine receptor subtypes and against an in vitro panel of 418 G-protein-coupled receptors, ion channels, transporters, and enzymes. 8a demonstrated ideal pharmaceutical properties for a CNS drug in regard to water solubility, permeability and lipophilicity and had low binding to human plasma proteins. It weakly inhibited recombinant cytochrome P450 isoforms and human ether-a-go-go-related gene. 8a metabolism was minimal in rat, mouse, dog, and human liver microsomes, and it had good interspecies pharmacokinetic properties. 8a dose-dependently inhibited H(3)R agonist-induced dipsogenia in the rat (ED(50) = 0.06 mg/kg po). On the basis of its pharmacological, pharmaceutical, and safety profiles, 8a was selected for preclinical development. The clinical portions of the single and multiple ascending dose studies assessing safety and pharmacokinetics have been completed allowing for the initiation of a phase IIa for proof of concept.
Solution structure of α‐conotoxin SI (2000)

The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, a high degree of similarity between the backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8 to Ser-12. This similarity is more surprising when considering that in SI a proline replaces the Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that it is the loss of the arginine basic charge at residue 9 which determines the differences in toxicity between GI and SI, rather than any changes in conformation induced by the cyclic proline residue.
The role of microRNA in nutritional control (2015)

MicroRNAs (miRNAs) are one of a growing class of noncoding RNAs that are involved in the regulation of a wide range of metabolic processes including cellular differentiation, cell proliferation and apoptosis. The generation of miRNA is regulated in complex ways, for example by small interfering RNAs (small nucleolar and nuclear RNAs) and various other metabolites. This complexity of control is likely to explain how a relatively small part of the DNA that codes for proteins has enabled the evolution of such complex organisms as mammals. Non-protein-coding DNA is therefore thought to carry the memory of early evolutionary steps that led to progressively complex metabolic controls. Clinically, miRNAs are becoming increasingly important following the recognition that some congenital abnormalities can be traced to defects in miRNA processing. The potential for manipulating metabolism and affecting disease processes by the pharmaceutical or biological targeting of specific miRNA pathways is now being tested. miRNAs are also released into the extracellular milieu after packaging by cells into nano-sized extracellular vesicles. Such vesicles can be taken up by adjacent and possibly more distant cells, thereby allowing coordinated intercellular communication in specific tissues. Extracellular miRNAs found in the blood stream may also serve as novel biomarkers for both diagnosing specific forms of cancer and assessing the likelihood of metastasis, and as powerful prognostic indices for various cancers. Here, we discuss the role of intracellular and extracellular miRNAs in nutritional control of various (patho)physiological processes. In this review, we provide an update of the presentations from the 25th Marabou Symposium (Stockholm, 14-16 June 2013) entitled 'Role of miRNA in health and nutrition', attended by 50 international experts
Generation of Diverse Dynamic Behaviors Using the Emergent Design System (2011)

Herein we examined the first step for constructing an emergent design system capable of generating diverse behaviors. We proposed method to generate diverse dynamic behaviors. The form generation method in the emergent design system initially generated diverse two-dimensional forms, and forms with various features were then produced by changing the composite ratio k, which is a system parameter. Then these forms were converted into two-dimensional mass point systems composed of mass points, springs, and dampers. The behaviors of the two-dimensional mass point systems were analyzed by the Runge-Kutta method to examine the effects of applying external forces such as loads and vibrations on the various behaviors such as rotational movement. Our results indicated that diverse forms with different displacement tracks of the center of gravity are also generated under the same mechanical conditions
Adaptive cooled mirror for the resonator of an industrial laser (1985)

The construction of a semipassive adaptive cooled bimorph mirror is described. The results are given of an investigation of its principal characteristics, such as the sensitivity and the response function of the electrodes. The results of tests under the influence of a high-power laser beam are also given.
Digital item adaptation: overview of standardization and research activities (2005)

MPEG-21 Digital Item Adaptation (DIA) has recently been finalized as part of the MPEG-21 Multimedia Framework. DIA specifies metadata for assisting the adaptation of Digital Items according to constraints on the storage, transmission and consumption, thereby enabling various types of quality of service management. This paper provides an overview of DIA, describes its use in multimedia applications, and reports on some of the ongoing activities in MPEG on extending DIA for use in rights governed environments.
Population attributable fraction (PAF) in repeated measures design: Childhood traumas as predictors of psychotherapy outcomes (2017)

Introduction Population attributable fraction (PAF) represents the proportion of treatment failure, which could be avoided, if the individuals at high risk were similar to the individuals at low risk. The PAF, however, has not been available for repeated measures designs. A relatively prevalent and strong risk factor for many adulthood disorders, such as depression and anxiety, are adversities and traumas experienced in childhood. Little is, however, known of their implications for common treatments such as psychotherapy. Objectives To develop PAF for repeated measures, and to provide a useful tool in various research fields to provide decision-makers results, which are easier to interpret. This study will examine the relative importance of different childhood traumas as predictors of psychotherapy outcome in a patient population with depressive and anxiety disorders. Methods PAF was calculated using generalized linear mixed models and Bayesian predictive distributions. The data is based on 326 outpatients, randomized in one long-term and two short-term psychotherapies by the Helsinki Psychotherapy Study. Patients were assessed up to 10 times during a 5-year follow-up. A combination of psychiatric symptoms measured, is used as the outcome measure. Results The repeated measures PAF will provide a useful aggregate measure over the follow-up time and over the patient population. Conclusions The repeated measures PAF will provide insight on the relative importance of the different domains of childhood traumas on therapy outcome. Associations of individual-level risk factors do not provide guidelines for policy decisions, which should acknowledge also prevalences of the risk factors in the patient population. Disclosure of interest The authors have not supplied their declaration of competing interest.
A biomimetic approach toward artificial bone-like materials (2001)

Bone consists of microcrystalline hydroxyapatite and collagen, an elastic protein matrix that is decorated with mineral-nucleating phosphoproteins. Our rational design of artificial bone-like material uses natural bone as a guide. Hydrogel and self-assembling polymers that possess anionic groups suitably positioned for nucleating biominerals, and therefore mimic the natural function of the collagen-phosphoprotein matrix in bone, were designed to direct template-driven biomimetic mineralization of hydroxyapatite. The monomer library synthesis, hydrogel and self-assembling polymer formation and structural characterization of polymer scaffolds on both micro- and nano-levels are presented.
Analysis of the effects of operator experience and learning in laser sintering (2021)

Recent research into the cost performance of various additive manufacturing (AM) processes indicates that one important barrier is the extent of manual labour inputs required by the process. To exp...
Phase-Noise Analysis of Overlapping Filtered Multitone Waveforms in Millimeter-Wave Radio Systems (2018)

Future wireless networks demand multicarrier modulation schemes with improved spectrum efficiency and superior spectrum containment. Orthogonal frequency-division multiplexing (OFDM) has been the favorite technique, but due to its poor spectrum containment, various alternative schemes are under consideration. This paper focuses on the filtered multitone (FMT) scheme, one of the classical filter-bank multicarrier (FBMC) schemes utilizing QAM subcarrier symbols. In contrast to OFDM and the widely-studied FBMC/OQAM, FMT does not reach maximum spectrum density of subcarriers because non-overlapping subcarriers are required to reach orthogonality. In recent work, we have studied FMT with overlapping subcarriers to reach improved spectrum density, with the conclusion that significant overlap can be tolerated, depending on the required signal-to-interference ratio. Subcarrier overlap allows to increase the roll-off of the subcarrier frequency responses, which greatly simplifies the filter-bank implementation. In this paper we investigate the effects of phase-noise, in combination with intercarrier interference introduced by the subcarrier overlap. Phase-noise is particularly critical in millimeter-wave operation, which is a central element in future systems. We show that FMT has potential for significantly improving the performance under phase-nose. Flexible fast-convolution based scheme is applied for FMT generation and receiver processing, and the tradeoffs in the parametrization of overlapping FMT are characterized using practical phase-noise models.