gebhart/patrepeval huggingface dataset:
Tungsten-Vanadium mixed oxides for the oxidehydration of glycerol into acrylic acid (2011)

In this paper we report on the one-pot transformation of glycerol into acrylic acid, catalyzed by W/V mixed oxides, with hexagonal tungsten bronze (HTB) structure. The reaction requires two different catalyst functions, i.e., an acid one, which is given by W oxide, and an oxidizing one, given by the V ions incorporated within the WO3 lattice. W–O bronze is very active and moderately selective in acrolein formation, but yields only traces of acrylic acid. The incorporation of increasing amounts of V inside the hexagonal tungsten bronze structure, with the development of a monophasic compound, allows the consecutive oxidation of acrolein into acrylic acid. An optimal atomic ratio between W and V equal to V/(W + V) = 0.12–0.21 made it possible to obtain an acrylic acid yield of 25% (with selectivity to residual acrolein of 11%). However, during reaction under the oxygen-containing feed, the V4+ incorporated into the hexagonal bronze structure underwent a slow oxidation into V5+, which caused a progressive decline of selectivity to acrylic acid and a concomitant increase of COx formation; the hexagonal structure however was stable during lifetime experiments. On the other hand, in the absence of oxygen a very rapid deactivation of the catalyst occurred, with a decrease in selectivity to acrolein and increase in heavy by-products.
Supplementary Tables 1-4 from Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer (2023)

Supplementary Tables 1-4 from Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer
Fluides supercritiques et matériaux : de l’élaboration au recyclage (2019)

Invited talk
Science opportunities with solar sailing smallsats (2023)

Recently, we witnessed how the synergy of small satellite technology and solar sailing propulsion enables new missions. Together, small satellites with lightweight instruments and solar sails offer affordable access to deep regions of the solar system, also making it possible to realize hard-to-reach trajectories that are not constrained to the ecliptic plane. Combining these two technologies can drastically reduce travel times within the solar system, while delivering robust science. With solar sailing propulsion capable of reaching the velocities of ~5-10 AU/yr, missions using a rideshare launch may reach the Jovian system in two years, Saturn in three. The same technologies could allow reaching solar polar orbits in less than two years. Fast, cost-effective, and maneuverable sailcraft that may travel outside the ecliptic plane open new opportunities for affordable solar system exploration, with great promise for heliophysics, planetary science, and astrophysics. Such missions could be modularized to reach different destinations with different sets of instruments. Benefiting from this progress, we present the "Sundiver" concept, offering novel possibilities for the science community. We discuss some of the key technologies, the current design of the Sundiver sailcraft vehicle and innovative instruments, along with unique science opportunities that these technologies enable, especially as this exploration paradigm evolves. We formulate policy recommendations to allow national space agencies, industry, and other stakeholders to establish a strong scientific, programmatic, and commercial focus, enrich and deepen the space enterprise and broaden its advocacy base by including the Sundiver paradigm as a part of broader space exploration efforts.
Subsequent Pregnancy After Gestational Diabetes Mellitus (2008)

GDM recurred in nearly half of subsequent pregnancies in Korean women. Fasting glucose 2 months postpartum might be a clinically valuable predictor of recurrent GDM risk.
Hcmv-miR-UL22A-5p: A Biomarker in Transplantation With Broad Impact on Host Gene Expression and Potential Immunological Implications (2015)

Cytomegalovirus (CMV) encodes multiple microRNAs. While these have been partially characterized in vitro, their relevance to clinical CMV infection has not been evaluated. We analyzed samples from a cohort of solid organ transplant patients with CMV disease (n = 245) for viral microRNA expression. Several CMV microRNAs were readily detectable in patients with CMV disease in variable relative abundance. Expression level generally correlated with DNA viral load and the absence of viral microRNA was associated with faster viral clearance. Detection of hcmv-miR-UL22A-5p at baseline independently predicted the recurrence of CMV viremia upon discontinuation of antiviral therapy (OR 3.024, 95% CI: 1.35-6.8; p = 0.007). A combination of direct mRNA targeting by the microRNA and indirect modulation of gene expression involving isoforms of the transcriptional regulator C-MYC may be responsible for the broad effects seen in the association of gene transcripts with the RNA-induced silencing complex and in global protein expression upon hcmv-miR-UL22A-5p transfection. This novel study of in vivo viral microRNA expression profiles provides unique insight into the complexity of clinical CMV infection following transplantation. We provide evidence that viral microRNAs may have complex effects on gene expression and be associated with specific virologic and clinical outcomes, and thus could be further evaluated as biomarkers.
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels (2016)

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P&lt;10−6 in 19,979 additional individuals. We identify five loci robustly associated (P&lt;5 × 10−8) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
A 3GHz to 7GHz fast-hopping frequency synthesizer for UWB (2004)

A 3 to 7 GHz fast-hopping frequency synthesizer for ultra-wideband (UWB) applications, realized in a standard digital 0.13 /spl mu/m CMOS copper technology is presented. The synthesizer is based on single-sideband (SSB) up- or downconversion of a low frequency (LF) input by means of an integrated LC-VCO used as local oscillator (LO). Two LO are selectable to achieve the large output frequency range with reduced LF bandwidth requirements. This select multiplexer can also be used to pulse the output frequency of the synthesizer with switching times less than 1 nsec. Operating from a 1.5 V supply the LO leakage and sideband suppression is better than -25 dBc for downconversion and <-18 dBc for upconversion, which is sufficient for UWB applications. Measured output frequency range is 3.3 to 6.1 GHz, limited by measurement equipment. Power consumption is 95 mW and module area 0.7 mm/sup 2/ including pads.
Pseudo Constant Time Implementations of TLS Are Only Pseudo Secure (2018)

Today, about 10% of TLS connections are still using CBC-mode cipher suites, despite a long history of attacks and the availability of better options (e.g. AES-GCM). In this work, we present three new types of attack against four popular fully patched implementations of TLS (Amazon's s2n, GnuTLS, mbed TLS and wolfSSL) which elected to use "pseudo constant time" countermeasures against the Lucky 13 attack on CBC-mode. Our attacks combine several variants of the PRIME+PROBE cache timing technique with a new extension of the original Lucky 13 attack. They apply in a cross-VM attack setting and are capable of recovering most of the plaintext whilst requiring only a moderate number of TLS connections. Along the way, we uncovered additional serious (but easy to patch) bugs in all four of the TLS implementations that we studied; in three cases, these bugs lead to Lucky 13 style attacks that can be mounted remotely with no access to a shared cache. Our work shows that adopting pseudo constant time countermeasures is not sufficient to attain real security in TLS implementations in CBC mode.
Noise reduction and control in mode-locked semiconductor diode lasers for use in next-generation all-optical analog-to-digital converters (2000)

External-cavity, actively-modelocked semiconductor diode lasers (SDLs) have proven to be attractive candidates for forming the backbone of next-generation analog-to-digital converters (ADCs), which are currently being developed to sample signals at repetition rates exceeding several GHz with up to 12 bits of digital resolution. Modelocked SDLs are capable of producing waveform-sampling pulse trains with very low temporal jitter (phase noise) and very small fluctuations in pulse height (amplitude noise)--two basic conditions that must be met in order for high-speed ADCs to achieve projected design goals. Single-wavelength modelocked operation (at nominal repetition frequencies of 400 MHz) has produced pulse trains with very low amplitude noise (approximately 0.08%), and the implementation of a phase- locked-loop has been effective in reducing the system's low- frequency phase noise (RMS timing jitter for offset frequencies between 10 Hz and 10 kHz has been reduced from 240 fs to 27 fs).
A KINETIC ANALYSIS OF THE EFFECTS OF INTERLEUKIN-2 DIPHTHERIA TOXIN FUSION PROTEIN UPON ACTIVATED T CELLS (1990)

The interleukin-2 diphtheria toxin-related fusion protein (IL-2 toxin) inhibits protein and DNA synthesis IN rIL-2 (10−10 M) stimulated T lymphoblasts in a dose-dependent fashion. However, prior to target cell death very low concentrations of rIL-2 and IL-2 toxin synergistically stimulate [H] thymidine incorporation despite inhibition of [14C] leucine uptake. A sequential analysis of [H] thymidine incorporation shows that high IL-2 toxin concentration (10−9–10−7 M) stimulates DNA synthesis at 18 hr of culture and inhibits [H] thymidine uptake after 24 hr, while low concentrations of IL-2 toxin (10−12–10−10 M) exhibits stimulatory effects only after 24 hr of culture. Anti-Tac a monoclonal antibody directed against the p55 chain of the high affinity IL-2 receptor (IL-2R) blocks the stimulatory effects of highdose IL-2 toxin, thereby proving that these effects are mediated through the IL-2 domain of the fusion protein. At 7 hr following interaction with IL-2R receptor (IL-2R)+ T cells, IL-2 toxin-treated cells evidence augmented transcription of the heat shock protein gene, an effect indistinguishable from those mediated by rIL-2. We conclude that interaction of IL-2 toxin with IL-2R+ T cells initially mimicks the stimulatory effects of IL-2 upon gene transcription and DNA synthesis yet concomitant inhibition of protein synthesis is evident.
2D Magnetic Fe0.75Ta0.5S2: Giant Exchange Bias with Broadband Photoresponse (2022)

Abstract Understanding the interplay between magnetic and optoelectronic properties and developing spin‐optoelectronic devices are promising research strategies to further study 2D materials and advance their applications. Here, the broadband photoresponse in the newly synthesized magnetic Fe 0.75 Ta 0.5 S 2 single crystals is reported. Because the uncompensated magnetic moment of the spin glass state is pinned by the moment of the antiferromagnetic state, a large exchange bias field of ≈1.98 T is found at 2 K when cooled down at a field of 7 T. The as‐prepared samples show a large negative magnetoresistance (nMR). The field dependence of nMRs displays a similar trend up to 50 K, which is likely to originate from the significant dependence of the localization length on magnetic field. In addition, a photodetector prepared using Fe 0.75 Ta 0.5 S 2 flakes exhibits a fast response time (121.7 ms), good stability, high responsivity of 26.1 A W −1 , and broadband photodetection, showing application potentials in spin‐optoelectronics.
Effect of Nandrolone Decanoate on the Anemia of Chronic Hemodialysis Patients (1977)

A double-blind cross-over study was conducted on 21 patients on maintenance hemodialysis to determine if changes in serum erythropoietin level, packed cell volume, red cell mass, hemoglobin concentration and 2,3-diphosphoglycerate content of red cells follow administration of nandrolone decanoate. There was a rise in mean serum erythropoietin level, packed cell volume, red cell mass and hemoglobin concentration. No alteration in mean 2,3-diphosphoglycerate content of red blood cells was found.
Trellis coded optical modulation using QAM constellations (2016)

We review TCM with 16QAM constellations. Multiple state TCM widens design options and provides two additional settings for flexible transponders. 8-state TCM 12QAM increases transmission distance by 880km at 3b/s/Hz. TCM benefits substantially from BP.
The Factors That Play a Role in the Decision-Making Process of Adult Deformity Patients (2009)

These results suggest that functional limitations are more important than pain for adult deformity patients when deciding for operative or nonoperative treatment.
Plasma Extracellular Vesicles as Liquid Biopsy to Unravel the Molecular Mechanisms of Cardiac Reverse Remodeling Following Resynchronization Therapy? (2023)

Cardiac resynchronization therapy (CRT) has become a valuable addition to the treatment options for heart failure, in particular for patients with disturbances in electrical conduction that lead to regionally different contraction patterns (dyssynchrony). Dyssynchronous hearts show extensive molecular and cellular remodeling, which has primarily been investigated in experimental animals. Evidence showing that at least several miRNAs play a role in this remodeling is increasing. A comparison of results from measurements in plasma and myocardial tissue suggests that plasma levels of miRNAs may reflect the expression of these miRNAs in the heart. Because many miRNAs released in the plasma are included in extracellular vesicles (EVs), which protect them from degradation, measurement of myocardium-derived miRNAs in peripheral blood EVs may open new avenues to investigate and monitor (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
Differential-Flatness-Based Planning and Control of a Wheeled Mobile Manipulator—Theory and Experiment (2010)

This paper presents a differential-flatness-based integrated point-to-point trajectory planning and control method for a class of nonholonomic wheeled mobile manipulator (WMM). We demonstrate that its kinematic model possesses a feedback-linearizable description due to the flatness property, which allows for full-state controllability. Trajectory planning can then be simplified and achieved by polynomial fitting method in the flat output space to satisfy the terminal conditions, while control design reduces to a pole-placement problem for a linear system. The method is then deployed on our custom-constructed WMM hardware to evaluate its effectiveness and to highlight various aspects of the hardware implementation.
Dielectric-Independent 2-MHz Propagation Resistivities (1999)

Dielectric-Independent 2-MHz Propagation Resistivities Peter T. Wu; Peter T. Wu Schlumberger Search for other works by this author on: This Site Google Scholar John R. Lovell; John R. Lovell Schlumberger Search for other works by this author on: This Site Google Scholar Brian Clark; Brian Clark Schlumberger Search for other works by this author on: This Site Google Scholar Stephen D. Bonner; Stephen D. Bonner Schlumberger Search for other works by this author on: This Site Google Scholar Jacques R. Tabanou Jacques R. Tabanou Schlumberger Search for other works by this author on: This Site Google Scholar Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. Paper Number: SPE-56448-MS https://doi.org/10.2118/56448-MS Published: October 03 1999 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Wu, Peter T., Lovell, John R., Clark, Brian, Bonner, Stephen D., and Jacques R. Tabanou. "Dielectric-Independent 2-MHz Propagation Resistivities." Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. doi: https://doi.org/10.2118/56448-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Annual Technical Conference and Exhibition Search Advanced Search This paper was prepared for presentation at the 1999 SPE Annual Technical Conference and Exhibition held in Houston, Texas, 3–6 October 1999. Keywords: dielectric effect, vertical resolution, resistivity, precision, log analysis, attenuation measurement, resistivity formation, spe 56448, dielectric-independent resistivity, borehole Subjects: Formation Evaluation & Management, Open hole/cased hole log analysis This content is only available via PDF. 1999. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
ChemInform Abstract: Chemistry of Boron. Part 190. Synthesis and Molecular Structure of 1,2‐Dihydrodiboretes and Azadiboretidines. (1988)

Abstract (2 + 2) Cycloadditions of the aminoborane (I) are studied with selected olefins, acetylenes and iminoboranes.
Supplementary Methods from Application of a Proapoptotic Peptide to Intratumorally Spreading Cancer Therapy (2023)

&lt;p&gt;PDF file - 92K&lt;/p&gt;
Effect of environmental stresses on antibody-based detection of Escherichia coli O157:H7, Salmonella enterica serotype Enteritidis and Listeria monocytogenes (2006)

In order to ensure the reliable detection of foodborne pathogens using antibody-based methods, the influence of stress on antibody reactions should be thoroughly examined and understood first as the physiological activities in cells are often altered in response to a stress.
1262-P: Circulating Lysophosphatidic Acid Levels Suggest a Metabolic Pathway in T3cDM and Distinguish It from T2DM (2023)

Introduction: Diabetes associated with chronic pancreatitis (T3cDM) has distinct clinical features. We investigated metabolomics signature to distinguish T3cDM from T2DM. Methods: Study participants (n=200); treatment naïve nonalcoholic calcific chronic pancreatitis [CP] patients (n=106, age 34.4±11.1 years, BMI 20.9±2.8), T2DM patients (n=68, age 46±10.7 years BMI 27.0±5.8), healthy controls (n=26, age 31.0±5.3 years, BMI 25.0±2.8) were recruited prospectively. OGTT was performed to define diabetes (ADA criteria) with 60% CP patients being normoglycemic, 19% having prediabetes and 21% with diabetes. Metabolomics was done on fasting plasma samples using liquid chromatography/mass spectrometry and quantifications were measured on tandem mass spectrometry. Student’s t-test, PLS-DA, ROCs were used to compare and compute to assess the performance of identified metabolites in distinguishing diabetes subtypes (T3cDM and T2DM). Regression analysis was employed to develop a prediction model. Results: A total of 5493 and 4104 metabolites were detected in T3cDM and T2DM respectively. Untargeted metabolome profiling identified significant differences in fatty acid conjugates in CP. Fatty acid conjugates were 28% in normoglycemic CP, 60% in prediabetic CP, 13% in T3cDM as compared to 42% in controls. Among them, 57 fatty acid conjugates showed increased peak intensities. Comparison of absolute quantifications identified higher lysophosphatidic acid (LPA) in T3cDM 40.50±6.55, T2DM 21.65 ± 1.75; p=0.01 in comparison to controls 16.20±3.4 ng/ml. Sensitivity and specificity for LPA were 81.8%, 78.6% with AUC 80% (p&amp;lt;0.0001), 95% CI (70.6-87.8). Prediction model (null and full model p&amp;lt;0.0001) and its performance (Hosmer-Lemeshow test p=0.9) indicated high accuracy (AUC 87%; 95% CI, 77.8-92.7). Conclusion: Increased Lysophosphatidic acid levels implicate glycerolipid pathway in the pathogenesis of T3cDM and can be used to distinguish T3cDM from T2DM. Disclosure V. Ketavarapu: None. M. Aslam: None. R. Talukdar: None. R. Amanchy: None. P. Sripadi: None. A.C. Powers: None. K. Narayan: None. K.C. Coate: None. L.R. Staimez: None. R. Jagannathan: None. N. D: None. M. Sasikala: None. Funding Science and Engineering Research Board, India Project (CRG/2019/005125)
ChemInform Abstract: SYNTHESES AND REACTIONS OF (4‐METHYL‐1H‐IMIDAZOL‐5‐YL)METHANETHIOL (1980)

Abstract Das aus den 5‐Halogenmethyl‐imidazolen (Ia) oder (Ib) zugängliche Thiol (II) reagiert über sein Thiolatanion mit den Alkylhalogeniden (III) zu den Mercaptanen (IV), und mit dem Tosylat (V) zu einem Gemisch aus Cimetidin (VI) (Therapeuticum gegen Ulcus pepticum) und den Ethylenguanidinen (VII) und (VIII).
Low-complexity ICI suppression for OFDM over time- and frequency-selective Rayleigh fading channels (2003)

While rapid variations of the fading channel cause intercarrier interference (ICI) in OFDM, thereby degrading its performance considerably, they also introduce temporal diversity, which can be exploited to improve the performance. We first derive a matched filter bound (MFB) for OFDM transmissions over doubly-selective Rayleigh fading channels, which benchmarks the best possible performance if ICI is completely cancelled without noise enhancement. We then develop low-complexity MMSE and DFE receivers for ICI suppression. Simulations show that the DFE receiver can collect significant gains of ICI-impaired OFDM with affordable complexity.
Probabilistic Object Detection: Definition and Evaluation (2020)

We introduce Probabilistic Object Detection, the task of detecting objects in images and accurately quantifying the spatial and semantic uncertainties of the detections. Given the lack of methods capable of assessing such probabilistic object detections, we present the new Probability-based Detection Quality measure (PDQ). Unlike AP-based measures, PDQ has no arbitrary thresholds and rewards spatial and label quality, and foreground/background separation quality while explicitly penalising false positive and false negative detections. We contrast PDQ with existing mAP and moLRP measures by evaluating state-of-the-art detectors and a Bayesian object detector based on Monte Carlo Dropout. Our experiments indicate that conventional object detectors tend to be spatially overconfident and thus perform poorly on the task of probabilistic object detection. Our paper aims to encourage the development of new object detection approaches that provide detections with accurately estimated spatial and label uncertainties and are of critical importance for deployment on robots and embodied AI systems in the real world.