gebhart/patrepeval huggingface dataset:
Abstract PO041: Landscape of molecular events regulating tumor cell responses to natural killer cells (2021)

Abstract Natural killer (NK) cells exhibit potent activity in pre-clinical models of diverse hematologic malignancies and solid tumors and infusion of high numbers of NK cells, either autologous or allogeneic, after their ex vivo expansion and activation, has been feasible and safe in clinical studies. To systematically define molecular features in human tumor cells which determine their degree of sensitivity to human allogeneic NK cells, we quantified the NK cell responsiveness of hundreds of molecularly-annotated “DNA-barcoded” solid tumor cell lines in multiplexed format (PRISM; Profiling Relative Inhibition Simultaneously in Mixtures approach), correlating cytotoxicity scores for each cell line with the CCLE transcriptional data (RNA-seq), to reveal genes that are associated with resistance or sensitivity to NK cells. In addition, we applied genome-scale CRISPR-based gene editing screens in several solid tumor cell lines to interrogate, at a functional level, which genes regulate tumor cell response to NK cells. Based on these orthogonal studies, NK sensitive tumor cells tend to exhibit high levels of the NK cell-activating ligand B7-H6 (NCR3LG1); low levels of the inhibitory ligand HLA-E; microsatellite instability (MSI) status; high transcriptional signature for chromatin remodeling complexes and low antigen presentation machinery genes. Treatment with an HDAC inhibitor reduced the sensitivity of SW620 colon cancer cells, increased antigen presentation machinery, including HLA-E, and reduced B7-H6. Importantly, we observe that transcriptional signatures of NK cell-sensitive tumor cells correlate with immune checkpoint inhibitor resistance in clinical samples. Strikingly, comprehensive analysis of the CCLE transcriptional signatures revealed that cell lines with mesenchymal-like program tend to be more sensitive to NK cells treatment, compared with cell lines of epithelial-like program. Indeed, mesenchymal tumors tend to have lower expression of antigen presentation machinery in both CCLE and TCGA, suggesting a link between these two machieneries. This study provides a comprehensive map of mechanisms regulating tumor cell responses to NK cells, with implications for future biomarker-driven applications of NK cell immunotherapies. Citation Format: Michal Sheffer, Emily Lowry, Nicky Beelen, Minasri Borah, Suha Naffar-Abu Amara, Chris C. Mader, Jennifer Roth, Aviad Tsherniak, Olga Dashevsky, Sara Gandolfi, Samantha Bender, Jordan Bryan, Cong Zhu, Li Wang, Ricardo De-Matos Simoes, Channing Yu, Yiguo Hu, Olli Dufva, Marios Giannakis, Todd Golub, Rizwan Romee, Satu Mustjoki, Aedin C. Culhane, Lotte Wieten, Constantine S. Mitsiades. Landscape of molecular events regulating tumor cell responses to natural killer cells [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2020 Oct 19-20. Philadelphia (PA): AACR; Cancer Immunol Res 2021;9(2 Suppl):Abstract nr PO041.
Optical polarization of m ‐plane In‐GaN/GaN light‐emitting diodes characterized via confocal microscope (2008)

Abstract A confocal microscope was applied to characterize near‐field optical polarization of light emission from InGaN‐based light‐emitting diodes prepared on a nonpolar orientation. Detection of stray light was significantly reduced as a result of the confocal technique compared to broad‐area measurements. The confocal measurement required no special sample preparation and obtained data was directly interpretable. A polarization ratio of 0.83 was measured on long‐wavelength emitting devices and was sustained over two orders of magnitude of low current range. Energy shifts and separation of emission peaks for the two polarization components were evaluated to discuss the valence‐band structure. Energy shifts indicated that the topmost band | X 〉 had a heavier effective mass than the lower band | Z 〉. Splitting energy of InGaN was estimated to be 30 meV. Results were consistent with the past reports, thus it was confirmed that the confocal microscope is a valid technique to characterize near‐field optical polarization. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A Study on Posture Estimation Using Inertial Sensor System in Standing Balance Evaluation with Translational Acceleration (2019)

In this study, we evaluate the effectiveness of the posture estimation method using an inertial sensor in the standing position generating small translational acceleration. Optimal motion capture system mainly used for motion analysis is expensive and takes many times for measurement and analysis. Inertial sensor consists of acceleration sensor and gyro sensor is inexpensive than optimal motion capture system, and the measurement using inertial sensor is easy. The estimation method is established the sensor fusion algorithm focused on the local coordinate system by using the Extended Kalman filter, and we estimated the 3D posture in the relative coordinate system by using the acceleration and the angular velocity. The measurement experiment was conducted to clarify the accuracy of the estimation method using the stabilometer generating disturbance, the wearable motion sensors installing inertial sensor and the motion capture system. We compared the results for ankle joint angle, knee joint angle and hip joint angle estimated by previous method and proposal method and focused on translational acceleration and segment acceleration. We indicated the effectiveness of proposed method measurement of standing with small translational acceleration.
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia (2022)

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structures of well-known kinase inhibitors and our previously developed purine derivatives. The synthesis of these purines was simple and used a microwave reactor for the final step. Kinase assays showed three inhibitors with high selectivity for each protein that were identified: <b>4f</b> (IC<sub>50</sub> = 70 nM for Bcr-Abl), <b>5j</b> (IC<sub>50</sub> = 0.41 μM for BTK) and <b>5b</b> (IC<sub>50</sub> = 0.38 μM for FLT-ITD). The 3D-QSAR analysis and molecular docking studies suggested that two fragments are potent and selective inhibitors of these three kinases: a substitution at the 6-phenylamino ring and the length and volume of the alkyl group at N-9. The N-7 and the <i>N</i>-methyl-piperazine moiety linked to the aminophenyl ring at C-2 are also requirements for obtaining the activity. Furthermore, most of these purine derivatives were shown to have a significant inhibitory effect in vitro on the proliferation of leukaemia and lymphoma cells (HL60, MV4-11, CEM, K562 and Ramos) at low concentrations. Finally, we show that the selected purines (<b>4i</b>, <b>5b</b> and <b>5j</b>) inhibit the downstream signalling of the respective kinases in cell models. Thus, this study provides new evidence regarding how certain chemical modifications of purine ring substituents provide novel inhibitors of target kinases as potential anti-leukaemia drugs.
Physical performance and self-report outcomes associated with use of passive, adaptive, and active prosthetic knees in persons with unilateral, transfemoral amputation: Randomized crossover trial (2015)

ClinicalTrials.gov; "Use of Passive, Adaptive, and Active Prosthetic Knees in Persons With Unilateral, Transfemoral Amputation": NCT02219230; https://clinicaltrials.gov/ct2/show/NCT02219230.
Plastic electronic devices: From materials design to device applications (2005)

Whether molecular solids, oligomers, or polymers, organic materials have been shown to be attractive candidates for both passive and active roles in electronic devices because of their compatibility with high-throughput, low-cost processing techniques and their capability to be precisely functionalized through the techniques of organic synthesis to afford desired performance attributes. Structure at both molecular- and nano-scale will impact attributes such as morphology (surface roughness, grain size), adhesion, mechanical integrity, solubility, and chemical and environmental stability. These factors, in turn, will affect device performance, notably electrical performance (mobility, conductivity, on/off ratio, threshold voltage). The challenges associated with the development of practical organic materials and associated device technologies for “plastic electronics” will be described and the relationships between materials structure and process performance will be discussed.
THERMAL RESISTANCE OF ORGANIC NANOPARTICLE COATINGS FOR HYDROPHOBICITY AND WATER REPELLENCE OF PAPER SUBSTRATES (2010)

Abstract The modification of paper substrates by organic nanoparticle coatings offers an attractive alternative for creating hydrophobic and water-repellent surfaces without fluorinated chemicals. The nanoparticles were synthesized by imidization of poly(styrene-maleic anhydride) and applied to a standard paper grade by means of a laboratory bar-coating process. The effects of supplementary heat treatments of the coated papers were investigated in terms of coating morphology and hydrophobicity: a unique coating structure is formed with a combination of microdomains that are internally structured at the nanoscale. The relatively high glass transition temperature of the nanoparticles allows for good thermal stability of the coating with almost no morphological changes at heating up to 180°C. The changes in chemical composition were investigated by diffuse reflectance infrared spectroscopy (DRIFT) and UV/VIS spectroscopy. The latter techniques qualitatively describe the effects of thermal treatments on the imide and styrene moieties. Contact angle measurements indicate that there is an optimum curing temperature in order to obtain a maximum advancing contact angle of 133° to 150°.
UNUSUAL CASE OF DIRECT RELATIONSHIP BETWEEN TEMPERATURE AND RETENTION IN REVERSED-PHASE LIQUID CHROMATOGRAPHY (2013)

The effect of temperature on RP-LC retention of s-triazine derivatives containing amino amide substituents was studied. The slope of van't Hoff plots (ln(k′) vs 1/T) became less positive as the hydrophobicity of the amino amide R-groups increased. For derivatives containing two amino amide substituents, L-L diastereomers showed substantially less positive van't Hoff slopes compared to the corresponding L-D diastereomers. For the most hydrophobic R-group studied (isopropyl), a negative van't Hoff slope was found for the L-L diastereomer. The tendency towards less positive/more negative van't Hoff slopes for the L-L diastereomers was attributed to the existence of a particular conformational isomer having poor RP-LC retention, which was stabilized at low temperatures via an intramolecular hydrogen bond. Another observation in this study was the significant peak broadening as temperature was lowered. The free energy barrier to bond rotation was estimated based on the effect of temperature on the magnitude of peak broadening. Calculated values were in the range of 65–66 kJ/mol for the L-L diastereomers, which is very close to literature values for similar compounds. The accuracy of values obtained by this approach is discussed.
Supplementary Figures 1-8 from CD8<sup>+</sup> T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1 (2023)

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Corrosion Behavior and Surface Treatment of Cladding Materials Used in High-Temperature Lead-Bismuth Eutectic Alloy: A Review (2021)

Liquid metal fast reactors were considered to be the most promising solution to meet the enormous energy demand in the future. However, corrosion phenomenon caused by the liquid metal, especially in high-temperature lead-bismuth coolant, has greatly hindered the commercialization of the advanced Generation-IV nuclear system. This review discussed current research on the corrosion resistance of structural materials (such as EP823, T91, ODS, and authentic steels) in high-temperature liquid metal served as reactor coolants. The current corrosion resistance evaluation has proved that even for the excellent performance of EP823, the structural material selected in pressurized water reactor is not the ideal material for operation in the high-temperature lead-bismuth eutectic (LBE). Furthermore, the latest coating technologies that are expected to be applied to cladding materials for coolant system were extensively discussed, including Al-containing coatings, ceramic coatings, oxide coatings, amorphous coatings and high-entropy alloy coatings. The detailed comparison summarized the corrosion morphology and corrosion products of various coatings in LBE. This review not only provided a systematic understanding of the corrosion phenomena, but also demonstrated that coating technology is an effective method to solve the corrosion issues of the advanced next-generation reactors.
Design and Optimization of an Axial Flux Permanent Magnet Assisted Eddy Current Brake (2020)

In this paper, design method of an axial gap permanent magnet (PAW assisted eddy-current brake is proposed by magnetic circuit based modeling and particle swarm optimization. The magnets in the investigated brake topology are placed into slot openings of the structure so as to increase the braking torque. This differs the design from conventional magnet-free brake structures. The proposed brake is modeled by a reluctance based network and Newton-Raphson approach is used as nonlinear solver. A multiobjective particle swum optimization is created and used in the design case, which aims to have 28 Ntn of braking torque. The optimized model is obtained by nondominating results in three-dimensional Pareto surfaces and analytical results are compared with finite element analyses. The results obtained from the analytical approach and the FEA agree well and it is shown that the investigated design methodology is an effective and fast approach so as to obtain the optimized design parameters in such eddy current brake structures.
Impact of contact force sensing technology on outcome of catheter ablation of idiopathic pre-mature ventricular contractions originating from the outflow tracts (2020)

The use of CF-sensing technology is not associated with increased success rate nor decreased complication rate in idiopathic outflow tract PVC ablation.
hydrodynamic parameters for gas‐liquid cocurrent flow in packed beds (1985)

Abstract The hydrodynamics of cocurrent gas‐liquid flow in packed beds is analyzed by extending the concept of relative permeability to the inertial regime. The relative permeabilities of the gas and liquid phases are functions of the saturation of the liquid phase. These functions are found from an analysis of experimental data. The relations obtained are used to develop empirical correlations for predicting liquid holdup and pressure drop in gas‐liquid cocurrent downflow in packed beds over a wide range of operating conditions. The correlations proposed give very good results when compared to experimental data yielding, in general, mean relative deviations lower than existing correlations. In addition, a new equation is proposed for predicting static holdup in packed beds which is based on a more physically realistic characteristic length than that used in previous studies.
Temperature-Dependent Electrical Conductivity of GeTe-Based RF Switches (2015)

Abstract : The DC and RF electrical behavior of GeTe-based RF switches was characterized in both ON and OFF states at temperatures ranging from 25 K to 375 K. ON-state current-voltage characteristics vary only weakly with temperature, exhibiting Ohmic behavior at all temperatures across the full voltage range measured. OFF-state current varies linearly with voltage at all measured fields for low temperatures, but transitions to super-linear behavior at higher fields and temperatures. Unlike the ON-state case, the low-field OFF-state DC conductance exhibits considerable temperature dependence, decreasing four orders of magnitude as the temperature is decreased from 375 K to 200 K, resulting in dramatically increased OFF/ON resistance ratios at low temperatures. RF performance, evaluated through small signal S-parameter measurements, exhibits minimal temperature variation in either the ON or OFF states.
Notice of Removal: Inter-transmission adaptive weighting for suppressing grating artifact in high-frame-rate synthetic transmit aperture beamforming (2017)

Removed.
Modeling the frequency dependence (5–120 MHz) of ultrasound backscattering by red cell aggregates in shear flow at a normal hematocrit (2003)

The frequency dependence of the ultrasound signal backscattered by blood in shear flow was studied using a simulation model. The ultrasound backscattered signal was computed with a linear model that considers the characteristics of the ultrasound system and tissue acoustic properties. The tissue scattering properties were related to the position and shape of the red blood cells (RBCs). A 2D microrheological model simulated the RBC dynamics in a Couette shear flow system. This iterative model, described earlier [Biophys. J. 82, 1696-1710 (2002)], integrates the hydrodynamic effect of the flow, as well as adhesive and repulsive forces between RBCs. RBC aggregation was simulated at 40% hematocrit and shear rates of 0.05-2 s(-1). The RBC aggregate sizes ranged, on average, from 3.3 RBCs at 2 s(-1) to 33.5 cells at 0.05 s(-1). The ultrasound backscattered power was studied at frequencies between 5-120 MHz and insonification angles between 0-180 degrees. At frequencies below approximately 30 MHz, the ultrasound backscattered power increased as the shear rate was decreased and the size of the aggregates was raised. A totally different scattering behavior was noted above 30 MHz. Typical spectral slopes of the backscattered power (log-log scale) between 5-25 MHz equaled 3.8, whereas slopes down to 0.6 were measured at 0.05 s(-1), between 40-60 MHz. The ultrasound backscattered power was shown to be angle dependent at low frequencies (5-25 MHz). The anisotropy persisted at high frequencies (>25 MHz) for small aggregates (at 2 s(-1)). In conclusion, this study sheds some light on the blood backscattering behavior with an emphasis on the non-Rayleigh regime. Additional experimental studies may be necessary to validate the simulation results, and to fully understand the relation between the ultrasound backscattered power, level of RBC aggregation, shear rate, frequency, and insonification angle.
A SARS-CoV-2 Coronavirus Nucleocapsid Protein Antigen-Detecting Lateral Flow Assay (2020)

Inexpensive, simple, rapid diagnostics are necessary for efficient detection, treatment and mitigation of COVID‑19. Currently, the primary diagnostic tool being utilized is reverse transcription polymerase chain reaction (RT-PCR). RT-PCR delivers results with good sensitivity and excellent specificity, but is expensive, prone to access challenges and is often slowed by transport to centralized testing laboratories. Antigen-based assays are inexpensive and can be rapidly mass-produced and deployed, with lateral flow assays (LFAs) being the most common inexpensive antigen test. To date, few antigen-detecting LFAs for COVID-19 have been commercialized. Herein, we present an open source LFA using commercially available antibodies and materials for the detection of SARS-CoV-2. Using an optical reader with comparable sensitivity to a visual read, the LFA yielded a Limit of Detection (LOD) of 23 TCID50/mL (95% CI of 9.1 to 37 TCID50/mL), equivalent to 1.4x105 copies/mL (95% CI of 5.5x104 to 2.3x105 copies/mL) irradiated virus in pooled nasal matrix. This LOD meets the criteria suggested by WHO for diagnosis of acute SARS-CoV-2 infection in a point of care format. A clinical evaluation and further testing is ongoing.
Design and characterization of electron beam focusing for X-ray generation in novel medical imaging architecture (2014)

A novel electron beam focusing scheme for medical X-ray sources is described in this paper. Most vacuum based medical X-ray sources today employ a tungsten filament operated in temperature limited regime, with electrostatic focusing tabs for limited range beam optics. This paper presents the electron beam optics designed for the first distributed X-ray source in the world for Computed Tomography (CT) applications. This distributed source includes 32 electron beamlets in a common vacuum chamber, with 32 circular dispenser cathodes operated in space charge limited regime, where the initial circular beam is transformed into an elliptical beam before being collected at the anode. The electron beam optics designed and validated here are at the heart of the first Inverse Geometry CT system, with potential benefits in terms of improved image quality and dramatic X-ray dose reduction for the patient.
Cultures of Stem Cells of the Central Nervous System (2003)

Over the past few years, the view that little or no cell turnover or replacement takes place within the adult central nervous system (CNS) has changed dramatically. The adult brain of both rodents and primates has been shown to embody undifferentiated, mitotically active precursor cells that are multipotential in nature and may contribute new, differentiated neurons and glia to specific regions of the mature brain, such as the olfactory bulb (Hinds, 1968a,Hinds, 1968b; Bayer, 1983; Corotto et al., 1993; Lois and Alvarez-Buylla, 1994), the hippocampus (Altman and Das, 1965; Kaplan and Bell, 1984; Kuhn et al., 1996) and the cortex (Kaplan, 1981; Huang and Lim, 1990; Gould, et al., 1999). Although this clearly suggests the presence of stem cells in the adult CNS in vivo, testing the proliferation, self-renewal, and differentiation capacity of “putative” CNS stem cells relies on the development of methodologies that allow for their extensive propagation and expansion in vitro.
ChemInform Abstract: Synthesis and Biological Evaluation of Sodium 2α‐(1,2,3‐Triazol‐ 1‐yl)methyl‐2β‐methyl‐6,6‐dihydropenam‐3α‐carboxylate‐1,1‐ dioxide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Desflurane, Sevoflurane, and Isoflurane Affect Left Atrial Active and Passive Mechanical Properties and Impair Left Atrial–Left Ventricular Coupling In Vivo (2001)

The results indicate that desflurane, sevoflurane, and isoflurane depress left atrial contractility, delay relaxation, reduce chamber stiffness, preserve reservoir and conduit function, and impair left atrial-left ventricular coupling in vivo.
Design and fabrication of silicon-tessellated structures for monocentric imagers (2016)

Compared with conventional planar optical image sensors, a curved focal plane array can simplify the lens design and improve the field of view. In this paper, we introduce the design and implementation of a segmented, hemispherical, CMOS-compatible silicon image plane for a 10-mm diameter spherical monocentric lens. To conform to the hemispherical focal plane of the lens, we use flexible gores that consist of arrays of spring-connected silicon hexagons. Mechanical functionality is demonstrated by assembling the 20-μm-thick silicon gores into a hemispherical test fixture. We have also fabricated and tested a photodiode array on a silicon-on-insulator substrate for use with the curved imager. Optical testing shows that the fabricated photodiodes achieve good performance; the hemispherical imager enables a compact 160 ° field of view camera with >80% fill factor using a single spherical lens.