gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Reductive Coupling and Cyclization of Carbon—Carbon Multiple Bonds (2011)

Abstract Review: 53 refs.
DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts (2010)

Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol beta) is known to be the main polymerase in the BER pathway, various studies have implicated other DNA polymerases in back-up roles. One such polymerase, DNA polymerase lambda (pol lambda), was shown to be important in BER of oxidative DNA damage. To further explore roles of the X-family DNA polymerases lambda and beta in BER, we prepared a mouse embryonic fibroblast cell line with deletions in the genes for both pol beta and pol lambda. Neutral red viability assays demonstrated that pol lambda and pol beta double null cells were hypersensitive to alkylating and oxidizing DNA damaging agents. In vitro BER assays revealed a modest contribution of pol lambda to single-nucleotide BER of base lesions. Additionally, using co-immunoprecipitation experiments with purified enzymes and whole cell extracts, we found that both pol lambda and pol beta interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases. Such interactions could be important in coordinating roles of these polymerases during BER.
ChemInform Abstract: Demethylation of Aromatic Methyl Ethers Using Ionic Liquids under Microwave Irradiation. (2011)

Abstract An efficient demethylation reaction for aromatic methyl ethers is described.
Ocrepeira klamt sp. n. (Araneae: Araneidae), a novel spider species from an Andean páramo in Colombia (2020)

Herein we describe Ocrepeira klamt sp. n. (Araneae: Araneidae), a new orb-weaving spider species from a Colombian páramo, which was formerly inaccessible for scientific studies due to decades long armed conflicts. Both, phenotypic and molecular data are used to confirm genus affiliation, and the new species is placed into phylogenetic context with other araneid spiders. Morphological characteristics and ecological notes of Ocrepeira klamt sp. n. are reported together with the sequence of the barcoding region of cytochrome c oxidase subunit I (COI) to provide a comprehensive description of the spider, facilitating future identification beyond taxonomic experts. With this study we contribute to the taxonomic knowledge that is required to inventory the hyper diverse yet threatened ecosystem of the Colombian páramos.
A linguistic analysis engine for natural language use case description and its application to dependability analysis in industrial use cases (2009)

We present 1) a novel linguistic engine made of configurable linguistic components for understanding natural language use case specification; and 2) results of the first of a kind large scale experiment of application of linguistic techniques to industrial use cases. Requirement defects are well known to have adverse effects on dependability of software systems. While formal techniques are often cited as a remedy for specification errors, natural language remains the predominant mode for specifying requirements. Therefore, for dependable system development, a natural language processing technique is required that can translate natural language textual requirements into validation ready computer models. In this paper, we present the implementation details of such a technique and the results of applying a prototype implementation of our technique to 80 industrial and academic use case descriptions. We report on the accuracy and effectiveness of our technique. The results of our experiment are very encouraging.
"A multi-resolution outdoor dual camera system for robust video-event metadata extraction" (2003)

This paper describes a cooperative distributed system for outdoor surveillance based on fixed and mobile cameras. In order to continuously monitor the entire scene, a fixed unidirectional sensor has been used, mounted on the roof of a building in front of the guarded area. To obtain higher resolution images of a particular region in the scene, an active pan-tilt-zoom camera has been used. The low resolution images are used to detect and locate moving objects in a scene. The estimated object position is used in order to evaluate pan-tilt movements that are necessary in order to focus the attention of the mobile-head camera on the considered object at a higher zoom level. The system is able to provide automatic change detection at multiple zoom levels. A video shot with a small zoom factor is used to monitor the entire scene from a fixed camera, while a medium and high zoom factor are used to improve interpretation of the scene. The use of a mobile camera allows one to exceed the limitations of the bounded field of view of the sensor imposed by a fixed camera. In this case it is not possible to provide a priori knowledge about the background of the scene. The proposed method for solving the non-fixed background problem for mobile cameras involves realization of a multilevel structure obtained by the acquisition of several images. The panoramic image of the whole scene is generated using a mosaicing technique. Both sensors are used to detect and estimate the precise location of a given object at different zoom levels in order to obtain a better position estimation.
Ready-Set-Transfer: Technology transfer in the requirements engineering domain (2013)

Requirements engineering research is undertaken to propose innovative solutions, to develop concepts, algorithms, processes, and technologies, to validate effective solutions for important requirements-related problems, and ultimately to support the transition of important findings to practice. However prior studies have shown that successful projects often take from 20-25 years to reach the stage of full industry adoption, while many other projects fizzle out and never advance beyond the initial research phase. This panel provides the opportunity for practitioners and academics to engage in a meaningful discussion around the topic of technology transfer. In this third offering of the Ready-Set-Transfer panel, three research groups will present products that they believe to be industry-ready to a panel of industrial practitioners. Each team will receive feedback from the panelists. The long-term goal of the panel is to increase technology transfer in the requirements engineering domain.
Hierarchical Sequential Detection In The Context Of Dynamic Spectrum Access For Cognitive Radios (2007)

Dynamic spectrum sharing is a concept where unlicensed devices are allowed to opportunistically access unused spectrum bands. The goal of this paper is to develop and analyze a novel secondary user sensing strategy that on the average minimizes the need to take sensing measurements and therefore maximizes throughput. In particular, we focus on the IEEE 802.22 standard where the goal is to detect TV signals. A secondary or unlicensed user must continuously monitor the band it is using and relinquish it as soon as it detects a primary or licensed user. The secondary user has to minimize its probability of missed opportunity to transmit while adhering to the probability of detecting the primary user. In this paper, we have applied the methods of sequential detection to reduce the sensing time. A collaborative detection scheme with the energy detector at the secondary user running a sequential detection test is used. The central node runs a parallel sequential test. Performance gains have been quantified for hard and soft decision combining at the central node and compared with the IEEE 802.22 wireless regional area network standard. The proposed scheme delivers a 3-204 times increase in throughput for SNRs in the range -10 dB to 0 dB.
Supplemental Figures S3-5 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs (2023)

&lt;p&gt;Supplemental Figures S3-5. Supplemental Figures S3: the gene expression changes induced by OTX015 in DLBCL cell lines. Supplemental Figures S4: network of genes affected by OTX015. Supplemental Figures S5: similar biologic effects of OTX015 and JQ1.&lt;/p&gt;
Depth enhanced and content aware video stabilization (2015)

We propose a system that uses depth information for video stabilization. The system uses 2D-homographies as frame pair transforms that are estimated with keypoints at the depth of interest. This makes the estimation more robust as the points lie on a plane. The depth of interest can be determined automatically from the depth histogram, inferred from user input such as tap-to-focus, or selected by the user; i.e., tap-to-stabilize. The proposed system can stabilize videos on the fly in a single pass and is especially suited for mobile phones with multiple cameras that can compute depth maps automatically during image acquisition.
Poly(urethane–carbonate)s from Carbon Dioxide (2017)

A one-pot, two-step protocol for the direct synthesis of polyurethanes containing few carbonate linkages through polycondensation of diamines, dihalides, and CO2 in the presence of Cs2CO3 and tetrabutylammonium bromide is described. The conditions were optimized by studying the polycondensation of CO2 with 1,6-hexanediamine and 1,4-dibromobutane as model monomers. Then, various diamines and dihalides were tested under optimal conditions. Miscellaneous samples of such carbonate-containing polyurethanes exhibiting molar masses from 6000 to 22 000 g/mol (GPC) and yields higher than 85% were obtained. The thermal properties of such polyurethanes were unveiled by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA): they were found very similar to those of traditional polyurethanes obtained by diisocyanates + diols polycondensation.
Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion (2018)

There are gaps in follow-up care for patients with mTBI after hospital discharge, even those with a positive finding on CT or who continue to experience postconcussive symptoms.
Identification of nonminimum phase systems using the second- and third-order statistics (1990)

The authors present a method for reconstruction of the impulse response of a nonminimum phase, linear, time-invariant (NMP-LTI) system from the second- and third-order statistics of the output sequence. The method is based on computing the complex cepstrum of the unknown impulse response from the power spectrum and a one-dimensional (1D) slice of the bispectrum. This method has the advantages of being independent of the type of the system (MA, AR, ARMA) and its computational complexity is also independent of the order of the utilized spectrum.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Hybrid Wing Body Engine Cycle Design Exploration for Boundary Layer Ingesting (BLI) Propulsion Systems Under Design Uncertainty (2012)

of the concept. The current paper presents a modeling approach that allows for the modeling of BLI at multiple design points and throughout the mission operating envelope. Furthermore, the paper presents a probabilistic engine cycle design space study for a 300 passenger HWB aircraft using the EDS design tool that explores the impacts of the various physical assumptions on the system level impacts. The results show that the system is particularly sensitive to the level of total pressure drop at the fan face. An engine sizing study shows that the level of assumed losses incurred by the engine has a large eect on the resultant size of the engine as well as on the performance of the sized engine at other assumed loss levels.
Substrate deprivation: A new therapeutic approach for the glycosphingolipid lysosomal storage diseases (2000)

The glycosphingolipid (GSL) lysosomal storage diseases are a family of human metabolic diseases that, in their severest forms, cause death in early infancy, as a result of progressive neurodegeneration. They are caused by mutations in the genes encoding the glycohydrolases or the activator proteins that catabolise GSLs within lysosomes. In these diseases the GSL substrate of the defective enzyme accumulates in the lysosome, where it is stored and leads to cellular dysfunction and disease. The therapeutic options for treating these diseases are relatively limited; in fact, there are currently no available therapies for most of these disorders. The problem is further compounded by difficulties in delivering therapeutic agents to the central nervous system, which is where the pathology is frequently manifested. To date, research effort has mainly focused on strategies for augmenting enzyme concentrations to compensate for the underlying defect. These strategies include bone-marrow transplantation, enzyme-replacement therapy and gene therapy. Our group has been exploring the alternative strategy of substrate deprivation. This approach aims to balance the rate of GSL synthesis with the impaired rate of GSL breakdown. Studies using an asymptomatic mouse model of Tay-Sachs disease have shown that substrate deprivation prevents GSL storage. In a severe neurodegenerative mouse model of Sandhoff disease, substrate deprivation delayed the onset of symptoms and disease progression, and significantly increased life expectancy. The implications of this research for human therapy have been discussed.
Janus—a comprehensive tool investigating the two faces of transcription (2013)

Supplementary data are available at Bioinformatics online.
High-Frequency Thermoacoustic Modulation Mechanisms in Swirl-Stabilized Gas Turbine Combustors—Part II: Modeling and Analysis (2016)

This paper deals with high-frequency (HF) thermoacoustic instabilities in swirl-stabilized gas turbine combustors. Driving mechanisms associated with periodic flame displacement and flame shape deformations are theoretically discussed, and corresponding flame transfer functions (FTF) are derived from first principles. These linear feedback models are then evaluated by means of a lab-scale swirl-stabilized combustor in combination with part one of this joint publication. For this purpose, the models are used to thermoacoustically characterize a complete set of operation points of this combustor facility. Specifically, growth rates of the first transversal modes are computed, and compared against experimentally obtained pressure amplitudes as an indicator for thermoacoustic stability. The characterization is based on a hybrid analysis approach relying on a frequency domain formulation of acoustic conservation equations, in which nonuniform temperature fields and distributed thermoacoustic source terms/flame transfer functions can be straightforwardly considered. The relative contribution of flame displacement and deformation driving mechanisms–i.e., their significance with respect to the total driving–is identified. Furthermore, promoting/inhibiting conditions for the occurrence of high frequency, transversal acoustic instabilities within swirl-stabilized gas turbine combustors are revealed.
The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection (2021)

The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show that the thymoproteasome shapes the TCR repertoire directly in cortical thymocytes before migration to the thymic medulla. We further show that the thymoproteasome optimizes CD8+ T cell production independent of the thymic medulla; independent of additional antigen-presenting cells, including medullary thymic epithelial cells and dendritic cells; and independent of apoptosis-mediated negative selection. These results indicate that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection in the thymus.
Increased Intratumoral FOXP3-positive Regulatory Immune Cells during Interleukin-2 Treatment in Metastatic Renal Cell Carcinoma (2009)

Intratumoral FOXP3-positive regulatory immune cells significantly increased during IL-2-based immunotherapy, and high numbers of on-treatment FOXP3-positive cells were correlated with poor prognosis in patients with metastatic renal cell carcinoma.
Scalability of dynamic storage allocation algorithms (2002)

Dynamic storage allocation has a significant impact on computer performance. A dynamic storage allocator manages space for objects whose lifetimes are not known by the system at the time of their creation. A good dynamic storage allocator should utilize storage efficiently and satisfy requests in as few instructions as possible. A dynamic storage allocator on a multiprocessor should have the ability to satisfy multiple requests concurrently. This paper examines parallel dynamic storage allocation algorithms and how performance scales with increasing numbers of processors. The highest throughputs and lowest instruction counts are achieved with multiple free list fit I. The best memory utilization is achieved using a best fit system.
Esmolol Improves Left Ventricular Function via Enhanced β-Adrenergic Receptor Signaling in a Canine Model of Coronary Revascularization (2002)

These data provide prospective evidence that esmolol administration results in improved myocardial function. Furthermore, the mechanism appears to involve enhanced myocardial beta AR signaling.
Selection and impedance based model of a lithium ion battery technology for integration with virtual power plant (2013)

The penetration of wind power into the power system has been increasing in the recent years. Therefore, a lot of concerns related to the reliable operation of the power system have been addressed. An attractive solution to minimize the limitations faced by the wind power grid integration is to integrate lithium-ion batteries into virtual power plants; thus, the power system stability and the energy quality can be increased. The selection of the best lithium-ion battery candidate for integration with wind power plants is a key aspect for the economic feasibility of the virtual power plant investment. This paper presents a methodology for selection, between three candidates, of a Li-ion battery which offers long cycle lifetime at partial charge/discharge (required by many grid support applications) while providing a low cost per cycle also. For the selected Li-ion battery an impedance-based diagnostic tool for lifetime estimation was developed and verified. This diagnostic tool can be extended into an impedance-based lifetime model that will be able to predict the remaining useful lifetime of Li-ion batteries for specific grid support applications.
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer. (2008)

The new micronized formulation of STX140 is orally bioavailable and efficacious at inhibiting MDA-MB-231 breast tumor growth.
Radar cross section statistics of ground vehicles at Ku-band (2011)

Knowing the statistical characteristics of a target's radar cross-section (RCS) is crucial to the success of radar target detection algorithms. Open literature studies regarding the statistical nature of the RCS of ground vehicles focus primarily on simulations, scale model chamber measurements, or limited experimental data analysis of specific vehicles at certain frequencies. This paper seeks to expand the existing body of work on ground vehicle RCS statistics at Ku-band for ground moving target indication (GMTI) applications. We examine the RCS probability distributions of civilian and military vehicles, across aspect and elevation angle, for HH and VV polarizations, and at diverse resolutions, using experimental data collected at Ku-band. We further fit Swerling target models to the distributions and suggest appropriate detection thresholds for ground vehicles in this band.
Enabling efficient heat-to-electricity generation at the mesoscale (2017)

We present a technology that efficiently harnesses the energy content of hydrocarbon fuels in a volume that is only a fraction of a cubic inch.
Renal and Electrolyte Effects of Total Parenteral Nutrition (1984)

Effects of short-term (4-14 days) total parenteral nutrition on renal handling of water and electrolytes were studied retrospectively in 24 patients and prospectively in eight patients. There was 33% incidence of hyponatremia and significant reductions in serum creatinine (from 1.03 +/- 0.06 to 0.88 +/- 0.06 mg/dl, p less than 0.001), phosphorus (from 3.2 +/- 0.14 to 2.5 +/- 0.17 mg/dl, p less than 0.005) and uric acid (from 6.09 +/- 0.38 to 3.66 +/- 0.24 mg/dl, p less than 0.001) were observed. Hypouricemia correlated with increased fractional excretion of urate (r = 0.81, p less than 0.05). Hypophosphatemia was associated with increased tubular reabsorption of phosphate. Clearance studies in eight patients showed high urine flow rate (1.7 +/- 0.2 ml/min), osmolar clearance (3.2 +/- 0.7 ml/min), urinary nonelectrolyte, nonurea solute excretion (0.23 +/- 0.14 mmol/min), and negative free water clearance (TcH2O = 1.5 +/- 0.6 ml/min). These data suggest presence of compartmental shifts, expanded extracellular fluid volume, and possible direct effects on renal tubular transport functions during total parenteral nutrition.
Ascending Proxy Auctions (2005)

Introduction Theoretical treatments of auctions usually analyze situations in which there is some particular item to be bought or sold and the question is what auction format to use. In real auctions, however, the important planning starts much earlier and is much more encompassing. For example, in a bankruptcy auction, the auctioneer may need to decide whether to sell a whole company as a single unit or its various assets individually, what guarantees to offer concerning the conditions of its physical assets, what kinds of financing terms to require, how much time to allow buyers to obtain needed regulatory or other approvals for the acquisition, and so on.
Double MZI Micro-Opto-Mechanical Pressure Sensors for increased sensitivity and pressure range (2017)

This paper presents a novel integrated Micro-OptoMechanical Pressure Sensor that exhibits an excellent measurement precision in a large pressure range. The performance gain compared to classical designs is obtained by using a phase shift and by combining two MachZendher Interferometers (MZIs) on a single membrane: one with high sensitivity and one with large range. A balanced design and a power tap output allow to de-embed the noise generated by the laser and eases bandwidth requirements, allowing the use of an off-the-shelf laser diode. Using low-temperature deposited PECVD SiN as waveguide core, the new MZI Micro-Opto-Mechanical Pressure Sensor can be post-processed directly on CMOS imager/detector wafers.