gebhart/patrepeval huggingface dataset:
A design approach for ultrareliable real-time systems (1991)

A design approach developed over the past few years to formalize redundancy management and validation is described. Redundant elements are partitioned into individual fault-containment regions (FCRs). An FCR is a collection of components that operates correctly regardless of any arbitrary logical or electrical fault outside the region. Conversely, a fault in an FCR cannot cause hardware outside the region to fail. The outputs of all channels are required to agree bit-for-bit under no-fault conditions (exact bitwise consensus). Synchronization, input agreement, and input validity conditions are discussed. The Advanced Information Processing System (AIPS), which is a fault-tolerant distributed architecture based on this approach, is described. A brief overview of recent applications of these systems and current research is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Catalytic Cleavage of Ether C—O Bonds by Pincer Iridium Complexes. (2015)

Abstract Optimized conditions including the pincer complex shown allow the cleavage of substrates (I) and (III) to produce the corresponding phenol components, accompanied by olefins derived from the alkyl substituents R.
Antisense Bcl-x oligonucleotide induces apoptosis and prevents arterial neointimal formation in murine cardiac allografts (2000)

These results indicate that apoptosis of vascular SMCs induced by Bcl-x is associated with initial hyperplasia after heart transplantation. Antisense bcl-x ODN inhibits SMC proliferation by inducing apoptosis in graft coronary arteries.
ChemInform Abstract: Ethylation of Ethylbenzene over Some Aluminosilicates with Molecular Sieve Structure. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rag proteins regulate amino-acid-induced mTORC1 signalling (2009)

The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism.
Acoustic Localization and Communication Using a MEMS Microphone for Low-cost and Low-power Bio-inspired Underwater Robots (2022)

Having accurate localization capabilities is one of the fundamental requirements of autonomous robots. For underwater vehicles, the choices for effective localization are limited due to limitations of GPS use in water and poor environmental visibility that makes camera-based methods ineffective. Popular inertial navigation methods for underwater localization using Doppler-velocity log sensors, sonar, high-end inertial navigation systems, or acoustic positioning systems require bulky expensive hardware which are incompatible with low cost, bio-inspired underwater robots. In this paper, we introduce an approach for underwater robot localization inspired by GPS methods known as acoustic pseudoranging. Our method allows us to potentially localize multiple bio-inspired robots equipped with commonly available micro electro-mechanical systems microphones. This is achieved through estimating the time difference of arrival of acoustic signals sent simultaneously through four speakers with a known constellation geometry. We also leverage the same acoustic framework to perform oneway communication with the robot to execute some primitive motions. To our knowledge, this is the first application of the approach for the on-board localization of small bio-inspired robots in water. Hardware schematics and the accompanying code are released to aid further development in the field3.
Eutectic Gallium–Indium (EGaIn): A Moldable Liquid Metal for Electrical Characterization of Self‐Assembled Monolayers (2007)

A great GaIn: Micrometer-sized conformal electrodes formed from the title compound are shown to be ideal for measuring the electrical properties of self-assembled monolayers. The image shows the bifurcation of the EGaIn between a metal needle and an Ag surface (not shown) at the point indicated by the two white arrows. The portion above the arrows will form the EGaIn electrode. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703642_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Supplementary Table S2 from Integrated Genomic Characterization of the Human Immunome in Cancer (2023)

&lt;p&gt;Table S2. Immunological gene signatures enriched in multiple cancer types.&lt;/p&gt;
Matching Space Antenna Deformation Electronic Compensation Strategies to Support Structure Architectures (2010)

Radar systems are engineered to achieve a complex, yet functional, balance between diverse subsystems and competing requirements. One important trade for large deployable space radar antennas is between antenna dimensional stability and electronic signal processing for deformation compensation. This trade is first investigated for several different electronic compensation methods, and compensation capabilities are mapped into structural requirements. Second the structural requirements are translated into appropriate structural architectures. The scope of this study is limited to space radar systems, where loads causing antenna deformations differ significantly from terrestrial systems. Compensation strategies that allow structural requirements to be reduced by several orders of magnitude are identified. When considered early in the systems engineering process, the methods presented herein can be used to form a rationale for the selection and the development of a complementary combination of compensation electronics and structural architectures.
A case study in top-down performance estimation for a large-scale parallel application (2006)

This work presents a general methodology for estimating the performance of an HPC workload when running on a future hardware architecture. Further, it demonstrates the methodology by estimating the performance of a significant scientific application -- the Gyrokinetic Toroidal Code (GTC) -- when executing on Sun's proposed next-generation petascale computer architecture.For GTC, we identify the important phases of the iteration and perform low-level analysis that includes instruction tracing and component simulations of processor and memory systems. Low-level analysis is complemented with scalability estimates based on modeling MPI, OpenMP and I/O activity in the code. The work's approach permits accurate end-to-end performance projections from the microarchitecture level to the petascale.
Learning Open-World Object Proposals without Learning to Classify (2021)

Object proposals have become an integral preprocessing steps of many vision pipelines including object detection, weakly supervised detection, object discovery, tracking, etc. Compared to the learning-free methods, learning-based proposals have become popular recently due to the growing interest in object detection. The common paradigm is to learn object proposals from data labeled with a set of object regions and their corresponding categories. However, this approach often struggles with novel objects in the open world that are absent in the training set. In this paper, we identify that the problem is that the binary classifiers in existing proposal methods tend to overfit to the training categories. Therefore, we propose a classification-free Object Localization Network (OLN) which estimates the objectness of each region purely by how well the location and shape of a region overlap with any ground-truth object (e.g., centerness and IoU). This simple strategy learns generalizable objectness and outperforms existing proposals on cross-category generalization on COCO, as well as cross-dataset evaluation on RoboNet, Object365, and EpicKitchens. Finally, we demonstrate the merit of OLN for long-tail object detection on large vocabulary dataset, LVIS, where we notice clear improvement in rare and common categories.
Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2-Induced DNA Damage by Chelating Intracellular Labile Iron (2012)

Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular "labile" iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.
Mesofluidic two stage digital valve (2023)

A mesofluidic scale digital valve system includes a first mesofluidic scale valve having a valve body including a bore, wherein the valve body is configured to cooperate with a solenoid disposed substantially adjacent to the valve body to translate a poppet carried within the bore. The mesofluidic scale digital valve system also includes a second mesofluidic scale valve disposed substantially perpendicular to the first mesofluidic scale valve. The mesofluidic scale digital valve system further includes a control element in communication with the solenoid, wherein the control element is configured to maintain the solenoid in an energized state for a fixed period of time to provide a desired flow rate through an orifice of the second mesofluidic valve.
Die Chirurgische Therapie von zystischen Pankreasläsionen - Erfahrungen aus dem StuDoQ|Pankreas Register (2021)

Einleitung Durch die vermehrte Anwendung moderner Schnitt-Bildgebung steigt die Inzidenz von zystischen Pankreasläsionen (PCL). Mangelnde Evidenz für therapeutische Strategien führt bei Ärzten und Patienten gleichermaßen zu Verunsicherung. Patienten, welche von einer Pankreasresektion profitieren, müssen präziser ausgewählt werden, um unnötige Risiken abzuwenden.
A Key Role for Chd1 in Histone H3 Dynamics at the 3′ Ends of Long Genes in Yeast (2012)

Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Previous studies of the Chd1 subclass of these proteins have implicated them in diverse roles in gene expression including functions during initiation, elongation, and termination. Furthermore, some evidence has suggested a role for Chd1 in replication-independent histone exchange or assembly. Here, we examine roles of Chd1 in replication-independent dynamics of histone H3 in both Drosophila and yeast. We find evidence of a role for Chd1 in H3 dynamics in both organisms. Using genome-wide ChIP-on-chip analysis, we find that Chd1 influences histone turnover at the 5' and 3' ends of genes, accelerating H3 replacement at the 5' ends of genes while protecting the 3' ends of genes from excessive H3 turnover. Although consistent with a direct role for Chd1 in exchange, these results may indicate that Chd1 stabilizes nucleosomes perturbed by transcription. Curiously, we observe a strong effect of gene length on Chd1's effects on H3 turnover. Finally, we show that Chd1 also affects histone modification patterns over genes, likely as a consequence of its effects on histone replacement. Taken together, our results emphasize a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster, and surprisingly they show that the major effects of Chd1 on turnover occur at the 3' ends of genes.
Composite Public Keys and Signatures (1998)

PKIs are used to provide scalability and ease key management. One type
of PKIs that is predominant for securing communications and data is
based on the X.509 standard. Since the security of PKIs, ultimately,
depends on the security of the cryptographic building blocks that are
used for authentication and encryption, the standards community made
algorithm agility a priority. Algorithm agility, in particular,
enables upgrading to newly available algorithms when needed. The
CompositeCrypto (i.e., CompositeKey and CompositeSignature structures)
described in this document provides an additional tool that enables
the use of multiple algorithms to authenticate data without the need
to use multiple certificates and more complex data structures. This
document provide the description of the definition and encoding rules
for CompositeKey and CompositeSignature. A description of how to use
these structures in main PKIX objects (e.g., X.509 certificates, CRLs,
OCSP responses, etc.) is also provided.
Gene expression analysis in sections and tissue microarrays of archival tissues by mRNA in situ hybridization. (2005)

Altered expression of genes in diseased tissues can prognosticate a distinct natural progression of the disease as well as predict sensitivity or resistance to particular therapies. Archival tissues from patients with a known medical history and treatments are an invaluable resource to validate the utility of candidate genes for prognosis and prediction of therapy outcomes. However, stored tissues with associated long-term follow-up information typically are formalin-fixed, paraffin-embedded specimen and this can severely restrict the methods applicable for gene expression analysis. We report here on the utility of tissue microarrays (TMAs) that use valuable tissues sparingly and provide a platform for simultaneous analysis of gene expression in several hundred samples. In particular, we describe a stable method applicable to mRNA expression screening in such archival tissues. TMAs are constructed from sections of small drill cores, taken from tissue blocks of archival tissues and multiple samples can thus be arranged on a single microscope slide. We used mRNA in situ hybridization (ISH) on >500 full sections and >100 TMAs for >10 different cDNAs that yielded >10,000 data points. We provide detailed experimental protocols that can be implemented without major hurdles in a molecular pathology laboratory and discuss quantitative analysis and the advantages and limitations of ISH. We conclude that gene expression analysis in archival tissues by ISH is reliable and particularly useful when no protein detection methods are available for a candidate gene.
Workshop: Best-practice for laboratory testing low-permeable materials (2021)

Abstract. The testing of low-permeable materials is challenging. Yet, for the disposal of radioactive waste, it is essential, too. This workshop is aimed at gathering ambitious scientists to discuss and to collaborate on their experiences in the laboratory testing of low-permeable materials. The focus here is on the methods: What method is best for what kind of low-permeable host rock (salt/clay) and for what kind of technical barrier material (bentonite/crushed salt)? How can measurement errors be correctly determined? What are the crucial “bottlenecks” in the device setups? How can high porous but low permeable samples best be pre-saturated? How can coupled flow and cumbersome gas traps in the tests be dealt with? What is the best-practice analysis of permeability from pressure decay recordings? Is there a hope of defining a standardized procedure for low-permeability testing? These points will be reflected in the light of radioactive waste disposal and in the need to find a best-practice solution when it comes to eventual evaluation and comparison of potential underground disposal sites.
Study On Coding Tools Beyond Av1 (2020)

The Alliance for Open Media has recently initiated coding tool exploration activities towards the next-generation video coding beyond AV1. With this regard, this paper presents a package of coding tools that have been investigated, implemented and tested on top of the codebase, known as libaom, which is used for the exploration of next-generation video compression tools. The proposed tools cover several technical areas based on a traditional hybrid video coding structure, including block partitioning, prediction, transform and loop filtering. The proposed coding tools are integrated as a package, and a combined coding gain over AV1 is demonstrated in this paper. Furthermore, to better understand the behavior of each tool, besides the combined coding gain, the tool-on and tool-off tests are also simulated and reported for each individual coding tool. Experimental results show that, compared to libaom, the proposed methods achieve an average 8.0% (up to 22.0%) overall BD-rate reduction for All Intra coding configuration a wide range of image and video content.
Determination of the Secondary Structure of Interleukin-8 by Nuclear Magnetic Resonance Spectroscopy (1989)

The solution conformation of interleukin-8 (IL-8), a small protein of 72 residues with a wide range of proinflammatory activities, has been investigated by two-dimensional NMR spectroscopy. The 1H-NMR spectrum of IL-8 is assigned in a sequential manner and regular elements of secondary structure are identified on the basis of a qualitative interpretation of the nuclear Overhauser, coupling constant and amide exchange data. The IL-8 monomer contains a triple stranded anti-parallel beta-sheet arranged in a Greek key and a long C-terminal helix (residues 57-72). It is shown that IL-8 is a dimer in solution in which the interface is principally formed by six backbone hydrogen bonds between residues 25, 27, and 29 of one monomer and residues 29, 27, and 25, respectively, of the other. As a result, the two units of the dimer form a contiguous six-stranded anti-parallel beta-sheet. The secondary structure of IL-8 is similar to that found in the crystal structure of the sequence related protein platelet factor 4.
Intramural Foci During Long Duration Fibrillation in the Pig Ventricle (2008)

For more than 50 years, it has been assumed that ventricular fibrillation (VF) is maintained solely by reentry in the working myocardium. This hypothesis has never been tested by recording VF with electrodes spaced sufficiently close to map activation sequences in 3D. We recorded the first 10 minutes of electrically induced VF from the anterior left ventricular (LV) free wall near the insertion of the anterior papillary muscle in 6 pigs. A 3D transmural unipolar electrode array consisting of a 9x9 array of needles with 2-mm spacing and 6 electrodes 2 mm apart on each needle was used for recordings. Automatic analyses were performed to recognize 3D reentry and foci. Our results showed that intramural reentry is present early but not late during VF in the mapped region. The incidence of reentry in working myocardium decreases almost to 0 after 3 minutes of VF. In contrast, intramural foci are present during early VF and, as VF continues, increase in incidence, so that by 10 minutes of VF, 27% of wavefronts arise from intramural foci. These results suggest that, particularly after the first 3 minutes of VF, mechanisms other than local reentry in the working myocardium maintain VF in the anterior LV free wall near the root of the anterior papillary muscle. Intramural foci may play an important role in later VF maintenance. It remains to be determined if these foci arise from Purkinje fibers attributable to abnormal automaticity, afterdepolarizations, or reentry.
Impact of a Yttria-Stabilized Zirconia Thermal Barrier Coating on HCCI Engine Combustion, Emissions, and Efficiency (2016)

In-cylinder surface temperature has significant impacts on the thermo-kinetics governing the Homogeneous Charge Compression Ignition (HCCI) process. Thermal Barrier Coatings (TBCs) enable selective manipulation of combustion chamber surface temperature profiles throughout a fired cycle. In this way, TBCs enable a dynamic surface temperature swing, which prevents charge heating during intake while minimizing heat rejection during combustion. This preserves volumetric efficiency while fostering more complete combustion and reducing emissions. This study investigates the effect of a Yttria-Stabilized Zirconia (YSZ) coating on Low Temperature Combustion (LTC) engine combustion, efficiency, and emissions. This is an initial step in a systematic effort to engineer coatings best suited for LTC concepts. A YSZ coating was applied to the top of the aluminum piston using a powder Air Plasma Spray process, Final thickness of the coatings was approximately 150 microns. The coated piston was subsequently evaluated in the single-cylinder HCCI engine with exhaust re-induction. Engine tests indicated significant advancement of the autoignition point and reduced combustion durations with the YSZ coating. Hydrocarbon and carbon monoxide emissions were reduced, thereby increasing combustion efficiency. The combination of higher combustion efficiency and decreased heat loss during combustion produced tangible improvements in thermal efficiency. When the effects of combustion advance were removed, the overall improvements in emissions and efficiency were lower, but still significant. Overall, the results encourage continued efforts to devise novel coatings for LTC.
Microcirculatory Free Flap Failure With Patent Anastomosis Salvaged by In Situ Thrombolysis in Vulnerable Phase Burn (2019)

Free flap reconstruction in acute burns has high failure rates, relating mainly to a systemic inflammatory state. The "vulnerable phase" can last for 6 weeks after burn and can cause thrombosis of the flap microcirculation with patent arterial and venous anastomoses. Revision surgery alone may be unsuccessful, but thrombolysis can lead to flap salvage. We describe a case of successful flap salvage with thrombolysis after unsuccessful revision surgery by permeable arterial and venous anastomoses in a patient in the acute burn phase suffering from microcirculatory thrombosis. Thrombolysis in these cases has not been described to date, but it could contribute to salvaging flaps by radiological intervention alone. A 23-year-old man was admitted with a 38% TBSA burn, including loss of all eyelid skin. The right eye was reconstructed in a satisfactory manner, but the left eye required urgent corneal coverage on day 32 with a dorsalis pedis fasciocutaneous free flap. The flap was hypo-perfused postoperatively, but anastomoses were found to be permeable on exploration. Angiography performed postoperatively after revision confirmed anastomotic patency, but failed to demonstrate small vessel beds within the flap. Thus, r-tPa was given at the anastomosis site and immediately the flap recovered completely. However, a total of 10 packed red blood cell transfusions were needed over the next 9 days. Thrombolysis in the context of free flap microvascular compromise may improve the overall success rates, especially in acute-phase burn patients where this etiology may be found, due to a vulnerable inflammatory period.
On Small-Depth Tree Augmentations (2021)

We study the Weighted Tree Augmentation Problem for general link costs. We show that the integrality gap of the ODD-LP relaxation for the (weighted) Tree Augmentation Problem for a $k$-level tree instance is at most $2 - \frac{1}{2^{k-1}}$. For 2- and 3-level trees, these ratios are $\frac32$ and $\frac74$ respectively. Our proofs are constructive and yield polynomial-time approximation algorithms with matching guarantees.