gebhart/patrepeval huggingface dataset:
Two-dimensional argon metastable density measurements in a radio frequency plasma reactor by planar laser-induced fluorescence imaging (1995)

Two-dimensional, relative measurements of the argon 1s5 metastable density distribution were obtained in a low-pressure, 13.56 MHz, parallel-plate, Gaseous Electronics Conference reference cell discharge using planar laser-induced fluorescence imaging. For the conditions examined (pure argon, 75–300 V, 13.3–133.3 Pa), the measured density fields show significant radial and axial variations that depend more strongly on pressure than applied voltage. Generally speaking, the metastable density increases radially from the center to the edge of the discharge by ∼10%–30%. As the pressure is increased, the peak metastable density increases by ∼4 times and the axial distribution changes from a center-peaked parabolic-like profile to an asymmetric profile peaked near the powered electrode. Comparisons of centerline metastable and excited-state emission profiles indicate that, while the metastable distribution is largely determined by the spatially dependent electron-impact excitation function, variations in quenching can significantly affect the resulting metastable density profile at some conditions.
A virtual excavator for controller development and evaluation (2002)

In order to facilitate the testing and evaluation of control strategies and operator environments designed for heavy duty hydraulic machines, an excavator simulator has been developed and is described in this paper. The simulator comprises an impedance model of the excavator arm, a model for the bucket-ground interaction forces, a graphical environment and a haptic interface. This paper describes the simulator components and their integration.
On the use of device-to-device communications for QoS and data rate enhancement in LTE public safety networks (2014)

In this paper, device-to-device (D2D) communications are investigated in the framework of LTE public safety networks. A clustering approach to enhance the performance of public safety D2D networks is proposed. In each cluster, a single device, the cluster head, is selected to communicate with the base station. It would then relay the information to/from the other cluster members. The performance of the proposed method is analyzed in both the uplink (UL) and downlink (DL) directions. It is compared to the scenario without D2D collaboration, and it is shown to lead to significant enhancements in terms of data rates and video quality of service (QoS).
Supporting model based diagnosis with evidence (1992)

The 'traditional' approach to diagnosis in plant and machinery has been to identify alarm conditions and present to the operator a indication of the alarm state when it arises. In certain pathological cases the flow of alarms can be sudden and in such numbers that the operators quickly become overloaded. However operators are frequently very successful if given sufficient time to assimilate the information. An operator's understanding of the machinery processes may be limited to some prior experience and not the principles on which it operates. By resorting to a description of the process at the level of governing principles, there is a clearer opportunity to find and correct the problem. The author presents the framework for using qualitative models in a framework where evidence from external tests can be introduced. The framework takes the form of a series of knowledge sources in a knowledge-based supervisory system. >
Open Architecture for Integrated Vehicle Health Management (2010)

A consensus in aerospace industry is that for IVHM technology to fully achieve its promise there is a need in establishing open architectures and standards. An open architecture would facilitate interaction of aircraft primes, subsystem OEMs, aircraft operators, government regulators, and research community in development and integration of IVHM systems from best available components. To answer this need, the IVHM Project in the NASA Aviation Safety Program is working on establishing an architectural framework for IVHM interoperability. This paper describes a NASA-led effort in IVHM architecture. The interoperability framework includes standardization of operations, functions, protocols, and information management models. NASA IVHM Project sponsors many new technology developments and expects that establishing the architectural framework would facilitate the technology transition to industry.
Surface modification of nanohydroxyapatite and its loading effect on polylactic acid properties for load bearing implants (2017)

Blends of polylactic acid (PLA) and nanohydroxyapatite (NHA) were prepared through melt‐mixing by varying the composition of NHA from 1 to 5 wt%. The tensile properties of the PLA‐1 wt% NHA nanocomposite exhibited higher values than neat PLA. Beyond 1 wt% NHA, a drop in tensile properties of the PLA–NHA nanocomposites was observed due to agglomeration and poor interfacial adhesion between NHA and PLA. Therefore, NHA was surface modified (mNHA) using three different surface modifiers namely, 3‐aminopropyl triethoxysilane (APTES), sodium n ‐dodecyl sulfate (SDS) and polyethylenimine (PEI). The surface treatment of NHA was studied through Fourier transform infrared spectroscopy (FTIR) and energy dispersive X‐ray (EDX). Results revealed that the tensile properties increased in order of PLA‐5 wt% mNHA (APTES) followed by PLA‐5 wt% mNHA (SDS), whereas PEI modified NHA resulted in lower tensile properties. Further, increasing mNHA loading to 30 wt%, decreased the tensile strength due to agglomeration of mNHA. POLYM. COMPOS., 39:2880–2888, 2018. © 2016 Society of Plastics Engineers
A Timescale Invariant STDP-Based Spiking Deep Network for Unsupervised Online Feature Extraction from Event-Based Sensor Data (2018)

We introduce a deep spiking convolutional neural network of integrate-and-fire (IF) neurons, which extracts hierarchical features from a stream of event-based vision data in an unsupervised fashion and online. Our network operates with a simple spike-timing dependent plasticity (STDP) rule, which does not require the definition of an input timescale. We demonstrate how our network is able to learn translational invariant features from the event-based N-MNIST dataset, while preserving dynamic information in the data. We demonstrate how these features can be used to perform online classification. Our network is the first neuromorphic system which can be used to learn complex hierarchical features unsupervised from a continuous stream of address-event-representation (AER) data, operating outside of a database framework and on multiple timescales. Additionally, all the mechanisms we use are simple and generic. This could open the possibility to implement our system on current neuromorphic hardware, to build a real-world fully adaptive event-based vision system.
YANG Data Model for the IS-IS Protocol (2022)

This document defines a YANG data model that can be used to configure
and manage IS-IS protocol on network elements.
Vector quantization of the articulatory space (1988)

A technique is presented for quantizing the articulatory space, i.e. for replacing the continuum of all possible vocal tract shapes by a finite set of shapes that span the articulatory space. Vocal tract shapes are represented as vectors of parameters that control an articulatory model, so vector quantization are applicable for deriving this codebook of tract shapes. Samples of the articulatory space are generated by interpolating model parameters along paths between selected target configurations. These shapes constitute the training data that are clustered to form the codebook. Such a codebook of shapes has direct application when vocal tract shapes must be estimated from speech. One such application, which motivated the present study, is the use of the codebook to providing starting configurations for an optimizing articulatory speech synthesizer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Rapid onsite assessment of spore viability. (2005)

This one year LDRD addresses problems of threat assessment and restoration of facilities following a bioterror incident like the incident that closed down mail facilities in late 2001. Facilities that are contaminated with pathogenic spores such as B. anthracis spores must be shut down while they are treated with a sporicidal agent and the effectiveness of the treatment is ascertained. This process involves measuring the viability of spore test strips, laid out in a grid throughout the facility; the CDC accepted methodologies require transporting the samples to a laboratory and carrying out a 48 hr outgrowth experiment. We proposed developing a technique that will ultimately lead to a fieldable microfluidic device that can rapidly assess (ideally less than 30 min) spore viability and effectiveness of sporicidal treatment, returning facilities to use in hours not days. The proposed method will determine viability of spores by detecting early protein synthesis after chemical germination. During this year, we established the feasibility of this approach and gathered preliminary results that should fuel a future more comprehensive effort. Such a proposal is currently under review with the NIH. Proteomic signatures of Bacillus spores and vegetative cells were assessed by both slab gel electrophoresis as well as microchip based gel electrophoresis employing sensitive laser-induced fluorescence detection. The conditions for germination using a number of chemical germinants were evaluated and optimized and the time course of protein synthesis was ascertained. Microseparations were carried out using both viable spores and spores inactivated by two different methods. A select number of the early synthesis proteins were digested into peptides for analysis by mass spectrometry.
Corrigendum: FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam (2021)

In the original article, the following authors were missing: Luigi Faillace, Lucia Giuliano, Mauro Migliorati, Luigi Palumbo. The corrected Author Contributions statement appears below. Affiliation 3, ‘Sapienza University of Rome, Rome, Italy’, is also added for authors LF, LG, MM, and LP. The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Electrical Contact Resistance Estimation for a Starter Motor by a Tuned Parameter Identification Technique (2012)

International audience
Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards (1997)

Four nitrogen mustards have been used in this study to examine protein-DNA interactions in intact human cells, specifically at the locus control region hypersensitive site-2 (LCR HS-2) of the human beta-globin locus. Three of these nitrogen mustards are DNA-targeted by attachment of an acridine or amsacrine intercalating chromophore, while the fourth (chlorambucil) is a non-targeted mustard. The ligation-mediated PCR technique was used to determine the sites of damage at base pair resolution on DNA sequencing gels. A densitometric comparison was made between DNA damaged in intact erythroid K562 cells and in purified DNA. The intensity of DNA damage sites in the LCR HS-2 were found to differ significantly between intact K562 cells and purified DNA. At the NF-E2/AP-1 motif, pronounced damage protection was observed in DNA derived from drug treated cells. The nuclear factor- erythroid 2 (NF-E2) protein factor is thought to bind at this NF-E2/AP-1 motif in K562 cells. Other sites of protection and enhancement that corresponded to known transcription factor binding sites were also detected. These nitrogen mustards are therefore very effective compounds for detection of transcription factor binding to DNA in intact cells and are superior to other commonly used agents. The sequence selectivity of the compounds was determined using plasmid DNA and compared to that found in intact cells. The acridine-based nitrogen mustard had a preference for forming adducts at guanine bases, while the two amsacrine-based nitrogen mustards and chlorambucil formed adducts at both guanine and adenine bases.
Supplementary Figure 1 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues (2023)

&lt;p&gt;PDF file - 287KB, Representative autofluorescence images and 3D renderings for each type of EETE.&lt;/p&gt;
Hybrid Analog-Digital Precoding for mmWave Coexisting in 5G-Satellite Integrated Network (2020)

Integrating massive multiple-input multiple-output (MIMO) into satellite network is regarded as an effective strategy to improve the spectral efficiency as well as the coverage of satellite communication. However, the inevitable intra-system and inter-system interference deteriorate the total performance of system. In this paper, we consider precoding in the 5G Satellite Integrated Network (5GSIN) with the deployment of Massive MIMO and propagation of shared millimeter-wave (mmWave) link. Taking the requirements of both frequency efficiency and energy assumption into account, a hybrid analog and digital pre-coding scheme in the specific scenario of 5GSIN is proposed. We model sum rate maximization problem for both of satellite and terrestrial system that incorporates maximum power constrains and minimum achievable rate requirements and formulate to a convex power allocation problem with Minimum Mean Square Error (MMSE) norm and Logarithmic Linearization method. In order to balance between performance and complexity, we propose an analog and digital separated hybrid precoding algorithm to mitigate intra-system interference. Moreover, an iterative power allocation with interference mitigation algorithm is also devised to mitigate interference from satellite to terrestrial link so that power allocation can be executed by generalized iterative algorithm. Simulation results show that our proposed hybrid precoding algorithm in 5GSIN can improve the overall spectral efficiency with a small amount of iterations.
The impact of parallel loop scheduling strategies on prefetching in a shared memory multiprocessor (1994)

Trace-driven simulations of numerical Fortran programs are used to study the impact of the parallel loop scheduling strategy on data prefetching in a shared memory multiprocessor with private data caches. The simulations indicate that to maximize memory performance, it is important to schedule blocks of consecutive iterations to execute on each processor, and then to adaptively prefetch single-word cache blocks to match the number of iterations scheduled. Prefetching multiple single-word cache blocks on a miss reduces the miss ratio by approximately 5% to 30% compared to a system with no prefetching. In addition, the proposed adaptive prefetching scheme further reduces the miss ratio while significantly reducing the false sharing among cache blocks compared to nonadaptive prefetching strategies. Reducing the false sharing causes fewer coherence invalidations to be generated, and thereby reduces the total network traffic. The impact of the prefetching and scheduling strategies on the temporal distribution of coherence invalidations also is examined. It is found that invalidations tend to be evenly distributed throughout the execution of parallel loops, but tend to be clustered when executing sequential program sections. The distribution of invalidations in both types of program sections is relatively insensitive to the prefetching and scheduling strategy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cytotoxic and DNA binding properties of aminoalkyl derivatives of di- and triazaphenanthrenes. (1992)

A series of mono- and dicationic derivatives of various di- and triazaphenanthrenes were synthesized and evaluated against both wild-type and amsacrine-resistant P388 leukemia in vitro. Monocationic derivatives of the fully-aromatic benzo[c][1,8]naphthyridine chromophore showed moderate and equal cytotoxicity in both cell lines, suggestive of efficacy against both the alpha and beta isozymes of mammalian DNA topoisomerase II. Derivatives of both the benzo[c][1,8]naphthyridine and benzo[c][1,8]naphthyridine-3(4H)-one chromophores also showed significant in vivo activity against wild-type P388 leukemia.
A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen (1983)

We have isolated a cDNA clone carrying a 1560 bp long insert which contains the entire coding and 3' untranslated regions of an H-2K(d) mouse histocompatibility antigen. Its sequence and overal features are described. They point to the existence of unique properties of DNA sequences associated with the H-2K(d) antigen.
Supplementary Figure 1 from Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche (2023)

&lt;p&gt;Growth and metastatic timeline of E0771 BCA and M3-9-M ERMS&lt;/p&gt;
Targeting T Cell-Specific Costimulators and Growth Factors in a Model of Autoimmune Hemolytic Anemia (2007)

Although it is established that failure of regulatory mechanisms underlies many autoimmune diseases, the stimuli that activate autoreactive lymphocytes remain poorly understood. Defining these stimuli will lead to therapeutic strategies for autoimmune diseases. IL-2-deficient mice develop spontaneous autoimmunity, because of a deficiency of regulatory T cells, and on the BALB/c background, they rapidly die from autoimmune hemolytic anemia. To define the importance of costimulatory pathways in various components of this autoimmune disorder, we first intercrossed IL-2-deficient mice with mice lacking CD28 or CD40L. Elimination of CD28 reduced the activation of autoreactive T cells and lymphoproliferation as well as production of autoantibodies, whereas elimination of CD40L reduced autoantibody production without affecting T cell expansion and accumulation. To examine the role of IL-7, we blocked IL-7R signaling with neutralizing Abs. This treatment inhibited the production of autoantibodies and the development of autoimmune hemolytic anemia. Together, these data indicate that specific costimulatory and cytokine signals are critical for the spontaneous autoantibody-mediated disease that develops in IL-2-deficient mice.
Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer (2016)

We report herein the synthesis and biological efficacy of near-infrared (NIR), bacteriochlorin analogues: 3-(1'-butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-N-butylimide methyl ester (3) and the corresponding carboxylic acid 10. In in vitro assays, compared to its methyl ester analogue 3, the corresponding carboxylic acid derivative 10 showed higher photosensitizing efficacy. However, due to drastically different pharmacokinetics in vivo, the PS 3 (HPLC purity >99%) showed higher tumor uptake and long-term tumor cure than 10 (HPLC purity >96.5%) in BALB/c mice bearing Colon 26 tumors. Isomerically pure R- and S- isomers of 3 (3a and 3b, purity by HPLC > 99%) under similar treatment parameters showed identical efficacy in vitro and in vivo. In addition, photosensitizer (PS) 3 showed limited skin phototoxicity and provides an additional advantage over the clinically approved chemically complex hematoporphyrin derivative as well as other porphyrin-based PDT agents, which makes 3 a promising dual-function agent for fluorescence-guided surgery with an option of phototherapy of cancer.
3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives:  Synthesis, In Vitro and In Vivo Anticancer Activity (2007)

Estradiol-3,17-O,O-bis-sulfamates inhibit steroid sulfatase (STS), carbonic anhydrase (CA), and, when substituted at C-2, cancer cell proliferation and angiogenesis. C-2 Substitution and 17-sulfamate replacement of the estradiol-3,17-O,O-bis-sulfamates were explored with efficient and practical syntheses developed. Evaluation against human cancer cell lines revealed the 2-methyl derivative 27 (DU145 GI(50) = 0.38 microM) as the most active novel bis-sulfamate, while 2-ethyl-17-carbamate derivative 52 (GI(50) = 0.22 microM) proved most active of its series (cf. 2-ethylestradiol-3,17-O,O-bis-sulfamate 4 GI(50) = 0.21 microM). Larger C-2 substituents were deleterious to activity. 2-Methoxy-17-carbamate 50 was studied by X-ray crystallography and was surprisingly 13-fold weaker as an STS inhibitor compared to parent bis-sulfamate 3. The potential of 4 as an orally dosed anti-tumor agent is confirmed using breast and prostate cancer xenografts. In the MDA-MB-231 model, dramatic reduction in tumor growth or regression was observed, with effects sustained after cessation of treatment. 3-O-Sulfamoylated 2-alkylestradiol-17-O-carbamates and sulfamates have considerable potential as anticancer agents.
HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2 (2015)

These findings indicate that RIPK1 and RIPK2 are targets of HIV-1 PR activity during infection, and their inactivation may contribute to modulation of cell death and host defense pathways by HIV-1.
Elevated frequency of a specific allele of the l‐MYC gene in male patients with bone and soft‐tissue sarcomas (1990)

Restriction fragment length polymorphisms (RFLPs) of 2 oncogenes, c-Ha-ras and L-myc, have been analyzed in 101 patients with bone and soft-tissue sarcoma and in 98 normal individuals. The c-Ha-ras gene was highly polymorphic both in sarcoma patients and in normal individuals. In contrast to our previous observation in breast cancer patients (Honda et al., 1988), no significant difference in allele frequencies between normal and sarcoma populations was observed. The L-myc locus revealed 2-allele polymorphism, allele L (10-kb) and S (6.6-kb), after digestion with Eco RI. The allele frequencies of L and S in sarcoma patients were 0.381 and 0.619, respectively, and those in normal individuals were 0.485 and 0.515, respectively. While the distributions of alleles in both populations fitted well with the Hardy-Weinberg equilibrium, the frequency of the S allele was significantly higher in sarcoma patients than in normal individuals (p less than 0.05). When sarcoma patients were divided into male and female subpopulations, this difference was highly significant only in males (p less than 0.01) but not in females. Our results suggest that males carrying the S allele may be prone to develop sarcoma.