gebhart/patrepeval huggingface dataset:
Update of CARTITUDE-1: A phase Ib/II study of JNJ-4528, a B-cell maturation antigen (BCMA)-directed CAR-T-cell therapy, in relapsed/refractory multiple myeloma. (2020)

8505 Background: JNJ-68284528 (JNJ-4528) is a chimeric antigen receptor T (CAR-T) cell therapy containing 2 BCMA-targeting single-domain antibodies. Here we present updated CARTITUDE-1 (NCT03548207) phase 1b results with longer follow-up. Methods: Pts had MM per IMWG criteria, measurable disease, received ≥3 prior regimens or were double refractory to a PI and IMiD, and received anti-CD38 antibody. Cyclophosphamide 300 mg/m 2 + fludarabine 30 mg/m 2 over 3 days were used for lymphodepletion. JNJ-4528 (median, 0.73x10 6 CAR+ viable T cells/kg) was given as a single infusion. Cytokine release syndrome (CRS) was graded by Lee et al2014 and neurotoxicity by CTCAE, v5.0 and ASTCT grading. Response was assessed per IMWG criteria. Results: As of 17 Jan 2020, median follow-up is 9 mo (3–17). Phase 1b enrollment is complete (N = 29 treated; median 5 (3–18) prior lines, 76% penta-exposed, 86% triple-refractory, 31% penta-refractory, 97% refractory to last line of therapy). Most frequent adverse events (AEs) were neutropenia (100%), CRS (93%), and thrombocytopenia (93%). Grade (Gr) ≥3 hematologic AEs were neutropenia (100%), thrombocytopenia (69%), and leukopenia (59%). 27 (93%) pts had CRS; 25 Gr 1–2, 1 Gr 3, and 1 Gr 5 (day 99 subsequent to dose-limiting toxicity of prolonged Gr 4 CRS). Median time to onset of CRS was 7 days (2–12). 4 pts had treatment-related neurotoxicity: 3 Gr 1–2 and 1 Gr 3. ORR was 100%, with 22 (76%) stringent complete responses (sCRs), 6 (21%) very good partial responses (VGPRs), and 1 (3%) PR. Median time to ≥CR was 2 mo (1–9). 26/29 pts are progression-free, with 6-mo progression-free survival rate of 93% and longest response ongoing at 15 mo. 1 death due to CRS and 1 to acute myeloid leukemia (not treatment-related) occurred during the study. All 16 pts (14 sCR, 2 VGPR) evaluable at 6 mo were minimal residual disease negative at 10 −5 or 10 −6 . JNJ-4528 CAR+ T cell expansion peaked between day 10–14. At 6-mo individual follow-up, 22/28 pts had JNJ-4528 CAR+ T cells below the level of quantification (2 cells/µL) in peripheral blood, suggesting CAR-T persistence in peripheral blood did not seem to correlate with deepening of response. At peak expansion, preferential expansion of CD8+ CAR-T cells with a central memory phenotype was observed in peripheral blood. Conclusions: JNJ-4528 treatment led to responses in all pts. These responses were early, deep, and durable at a low dose of CAR-T cells with 26/29 (90%) pts progression free at median 9-mo follow-up. CRS was manageable in most pts, supporting outpatient dosing. Clinical trial information: NCT03548207 .
On the multiple unicast capacity of 3-source, 3-terminal directed acyclic networks (2012)

We consider a directed acyclic network with unit-capacity edges and n source-terminal (s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> - t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> ) pairs that wish to communicate at unit rate via network coding. The connectivity between the s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> -t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> pairs is quantified by means of a connectivity level vector, [k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ... k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> ] such that there exist k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> edge-disjoint paths between s <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> and t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> . In this work we attempt to classify networks based on the connectivity level. Specifically, for case of n = 3, and a given connectivity level vector [k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ], we aim to either present a constructive network coding scheme or an instance of a network that cannot support the desired rate. Certain generalizations for the case of higher n have also been found.
ChemInform Abstract: π‐Facial Selectivity in Diels‐Alder Reactions of C‐2‐Vinyl Glycals. Stereocontrolled Route to Annulated C‐Glycopyranosides. (1990)

Abstract The diene (I) reacts with maleic anhydride (II) to produce selectively the cycloadduct (III).
Cross-media Scene Analysis: Estimating Objects' Visuals Only from Audio (2018)

Human beings can get a visual image of the surrounding environment from sounds they hear. Can we give similar capabilities to computers? In this article, we introduce our recent efforts in cross-media scene analysis applied to estimate the type, location, and visual shape of objects in a scene based only on sound sources recorded with multiple microphones.
Immunological Comparison of the Starch Branching Enzymes from Potato Tubers and Maize Kernels (1989)

Starch branching enzyme was purified from potato (Solanum tuberosum L.) tubers as a single species of 79 kilodaltons and specific antibodies were prepared against both the native enzyme and against the gel-purified, denatured enzyme. The activity of potato branching enzyme could only be neutralized by antinative potato branching enzyme, whereas both types of antibodies reacted with denatured potato branching enzyme. Starch branching enzymes were also isolated from maize (Zea mays L.) kernels. All of the denatured forms of the maize enzyme reacted with antidenatured potato branching enzyme, whereas recognition by antinative potato branching enzyme was limited to maize branching enzymes I and IIb. Antibodies directed against the denatured potato enzyme were unable to neutralize the activity of any of the maize branching enzymes. Antinative potato branching enzyme fully inhibited the activity of maize branching enzyme I; the neutralized maize enzyme was identified as a 82 kilodalton protein. It is concluded that potato branching enzyme (M(r) = 79,000) shares a high degree of similarity with maize branching enzyme I (M(r) = 82,000), in the native as well as the denatured form. Cross-reactivity between potato branching enzyme and the other forms of maize branching enzyme was observed only after denaturation, which suggests mutual sequence similarities between these species.
The Role of the Interleukin-1–Receptor Antagonist in Blocking Inflammation Mediated by Interleukin-1 (2000)

Approaches involving the blockade of inflammatory cytokines such as interleukin-1 and tumor necrosis factor α (TNF-α) are entering mainstream clinical medicine: antibodies against TNF-α and soluble receptors for TNF-α are being used to treat rheumatoid arthritis and Crohn's disease. A large number of preclinical studies form the scientific basis for these anticytokine-based therapies. In experiments in animals in which a disease involving several cytokines has been induced, administration of neutralizing antibodies or the use of other means to block the biologic activity of a specific cytokine attenuates the effects of the disease or halts its progression.A novel approach to . . .
Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11 (2016)

Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG-repeat expanding mutation in ATXN3. We generated induced pluripotent stem cells (iPSCs) from a SCA3 patient by electroporation of dermal fibroblasts with episomal plasmids encoding L-MYC, LIN28, SOX2, KLF4, OCT4 and short hairpin RNA targeting P53. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, could differentiate into the three germ layers in vitro and retained the disease-causing ATXN3 mutation. This iPSC line could be useful for the investigation of SCA3 disease mechanisms.
Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2 (2020)

Summary We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-CoV-2, focusing initially on the Spike (S) protein because it mediates infection of human cells and is the target of most vaccine strategies and antibody-based therapeutics. To date we have identified thirteen mutations in Spike that are accumulating. Mutations are considered in a broader phylogenetic context, geographically, and over time, to provide an early warning system to reveal mutations that may confer selective advantages in transmission or resistance to interventions. Each one is evaluated for evidence of positive selection, and the implications of the mutation are explored through structural modeling. The mutation Spike D614G is of urgent concern; it began spreading in Europe in early February, and when introduced to new regions it rapidly becomes the dominant form. Also, we present evidence of recombination between locally circulating strains, indicative of multiple strain infections. These finding have important implications for SARS-CoV-2 transmission, pathogenesis and immune interventions.
ChemInform Abstract: Addition—β‐Elimination: A New Method for the Preparation of Organometallic Compounds (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure 1 from Novel Changes in Glycosylation of Serum Apo-J in Patients with Hepatocellular Carcinoma (2023)

Supplementary Figure 1 from Novel Changes in Glycosylation of Serum Apo-J in Patients with Hepatocellular Carcinoma
Application of palladium-catalyzed [3 + 2] cycloaddition technology to the elaboration of kempane diterpenes. Stereocontrolled synthesis of (.+-.)-3.alpha.-hydroxy-7.beta.-kemp-8(9)-en-6-one and (.+-.)-3.beta.-hydroxykemp-7(8)-en-6-one (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of palladium-catalyzed [3 + 2] cycloaddition technology to the elaboration of kempane diterpenes. Stereocontrolled synthesis of (.+-.)-3.alpha.-hydroxy-7.beta.-kemp-8(9)-en-6-one and (.+-.)-3.beta.-hydroxykemp-7(8)-en-6-oneLeo A. Paquette, Daryl R. Sauer, Darryl G. Cleary, Mary A. Kinsella, Christopher M. Blackwell, and Lawrence G. AndersonCite this: J. Am. Chem. Soc. 1992, 114, 19, 7375–7387Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00045a007https://doi.org/10.1021/ja00045a007research-articleACS PublicationsRequest reuse permissionsArticle Views2635Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics (1993)

Abstract The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 1 ), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 2 ), and 8‐(aminomethyl)naphth‐2‐oic acid ( 3 ) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them ( 2 and 3 ) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34 – 36 ) designed as templates for the synthesis of TASP molecules.
Intrusion Pressure To Initiate Flow through Pores between Spheres (2012)

In this work, clusters of three or four spheres were used to examine intrusion pressure. Polytetrafluoroethylene (PTFE) or polyamide 66 (PA66) spheres were arranged horizontally to create a single pore. Liquid drops of water or ethylene glycol were gently introduced from above. If the spheres were too large, drops flowed through as soon as they were deposited. If the spheres were too small, liquid was suspended in the neck of the pore and could not pass through; drops became unstable and fell to one side. Alternatively, if spheres of a certain size were chosen, then capillary forces initially prevented drops of lesser stature from breaking though. However, as these drops grew taller, they eventually reached a height where the gravitational force exceeded the capillary force and the liquid flowed through the pore. A simple model for intrusion pressure was derived. Estimates from the model agreed well with experimentally measured values.
CCDC 840593: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
A 22 mW Multi-Standard Reconfigurable Spectrum Sensing Enabled Digital Frontend (2012)

Cognitive Radio requires the architecture of radio systems to combine reception and spectrum monitoring functionality efficiently. We propose a flexible digital front end that supports concurrent synchronization and sensing of high-throughput wireless standards. The chip is implemented in 65 nm CMOS technology resulting in a chip area of 6.4 mm2. Fine grain clock gating allows synchronization at 4 mW and sensing at 7 mW power consumption. Experiments with the chip in combination with a reconfigurable analog front end show that a 1.7 GHz wide frequency band can be scanned based on energy detection in an exceptionally low time window of 10 ms while consuming 13 mW power. Feature detection of DVB-T signals is implemented and measured as well and achieves for a single autocorrelation step a performance target false alarm rate of 10% and detection probability of 90% at an input power level of-106 dBm while consuming 7 mW power.
Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy (2020)

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that phenotypically resemble conventional secondary lymphoid organs and are commonly found at sites of chronic inflammation. They are also found in a wide variety of primary and metastatic human tumors. The presence of tumor-associated TLS (TA-TLS) is associated with prolonged patient survival, higher rates of disease-free survival, and a favorable response to current cancer therapies. However, the immune responses that occur in these structures, and how they contribute to improved clinical outcomes, remain incompletely understood. In addition, it is unknown how heterogeneity in TA-TLS cellular composition, structural organization, and anatomic location influences their functionality and prognostic significance. Understanding more about TA-TLS development, formation, and function may offer new therapeutic options to modulate antitumor immunity.
The Modelfest Perceptual Learning Initiative: A Status Report (2011)

Between ten and twenty years ago a broad range of perceptual learning (PL) results featured the lack of transfer across locations, tasks and features, implicating changes in early visual cortical areas. It held out promise for a simple unifying model of PL. In subsequent years the story has grown more complicated. Novel experimental protocols, many of which are summarized in Sagi's review “Perceptual Learning in Vision Research” (Vision Research (2010), doi:10.1017/j.visres.2010.10.019 or go to PubMed), show that learning can surprisingly transfer to untrained locations. Our recent results show that the learning can be transferred to untrained retinal locations and features even if an irrelevant task was used in one arm of the double training protocol. Competing principles have been formulated by several researchers for understanding this new data, but a concrete computational model to actually predict the data is lacking. The computational models that have been developed are generally used to predict the modelers own restricted data. In physics, where acquiring data is often costly, the researchers have come together to share in collecting critical data. This enables the computational modelers to test and distinguish among the competing models. The perceptual learning community has recently adopted this approach to collect a large trustworthy dataset for comparing models. At the 2010 Perceptual Learning Workshop in Israel, the Modelfest perceptual learning initiative was launched. The group considered not only what would be critical experiments, but also hidden methodological and statistical issues. This presentation reports on the current status of the ModelfestPL group's effort. In addition we will open up discussion for the next stage of the ModelfestPL deliberations.
Ribosome binding of DNA analogs of tRNA requires base modifications and supports the "extended anticodon". (1994)

The efficiency of translation depends on correct tRNA-ribosome interactions. The ability of chemically synthesized yeast tRNA(Phe) anticodon domains to effectively inhibit the binding of native yeast tRNA(Phe) to poly(U)-programmed Escherichia coli 30S ribosomal subunits was dependent on a Mg(2+)-stabilized stem and an open anticodon loop, both facilitated by base modifications. Analysis of tRNA sequences has revealed that base modifications which negate canonical hydrogen bonding are found in 95% of those tRNA anticodon loop sequences with the potential to form two Watson-Crick base pairs across the loop. Therefore, we postulated that a stable anticodon stem and an open loop are prerequisites for ribosome binding. To test this hypothesis, DNA analogs of the yeast tRNA(Phe) anticodon domain were designed to have modification-induced, Mg(2+)-stabilized stems and open loops. The unmodified DNA analog neither bound to poly(U)-programmed 30S ribosomal subunits nor inhibited the binding of native tRNA(Phe). However, specifically modified DNA analogs did bind to ribosomal subunits and effectively inhibited tRNA(Phe) from binding. Thus, modification-dependent Mg(2+)-stabilized anticodon domain structures with open loops have evolved as the preferred anticodon conformations for ribosome binding.
Towards systematic roadmaps for networked systems (2012)

Networked systems have benefited from unprecedented growth in hardware capabilities, but, as we move closer to the end of the Moore's law era, future networked systems are likely to be more constrained by hardware capabilities than they have been in the past. We take the position that the networking community should, in response to this development, proactively and systematically develop networking roadmaps, which attempt to predict how trends in hardware capabilities will impact networked systems. In this paper, we discuss a possible methodology for developing networking roadmaps, and present two case studies that illustrate the methodology and reveal how increasing hardware unreliability can affect the performance of routing and transport protocols.
Two types of human TCR differentially regulate reactivity to self and non-self antigens (2022)

Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations in thymic output and terminal deoxynucleotidyl transferase (TDT) activity. Neonatal TCRs derived from TDT-negative progenitors persist throughout life, are highly shared among subjects, and are reported as disease-associated. Thus, 10%-30% of most frequent cord blood TCRs are associated with common pathogens and autoantigens. TDT-dependent TCRs present distinct structural features and are less shared among subjects. TDT-dependent TCRs are produced in maximal numbers during infancy when thymic output and TDT activity reach a summit, are more abundant in subjects with AIRE mutations, and seem to play a dominant role in graft-versus-host disease. Factors decreasing thymic output (age, male sex) negatively impact TCR diversity. Males compensate for their lower repertoire diversity via hyperexpansion of selected TCR clonotypes.
ORCa: Glossy Objects as Radiance Field Cameras (2022)

Reflections on glossy objects contain valuable and hidden information about the surrounding environment. By converting these objects into cameras, we can unlock exciting applications, including imaging beyond the camera's field-of-view and from seemingly impossible vantage points, e.g. from reflections on the human eye. However, this task is challenging because reflections depend jointly on object geometry, material properties, the 3D environment, and the observer viewing direction. Our approach converts glossy objects with unknown geometry into radiance-field cameras to image the world from the object's perspective. Our key insight is to convert the object surface into a virtual sensor that captures cast reflections as a 2D projection of the 5D environment radiance field visible to the object. We show that recovering the environment radiance fields enables depth and radiance estimation from the object to its surroundings in addition to beyond field-of-view novel-view synthesis, i.e. rendering of novel views that are only directly-visible to the glossy object present in the scene, but not the observer. Moreover, using the radiance field we can image around occluders caused by close-by objects in the scene. Our method is trained end-to-end on multi-view images of the object and jointly estimates object geometry, diffuse radiance, and the 5D environment radiance field.
Models for process compensated resonant testing (PCRT) of silicon nitride balls (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John C. Aldrin, Leanne Jauriqui, Lem Hunter; Models for process compensated resonant testing (PCRT) of silicon nitride balls. AIP Conference Proceedings 25 January 2013; 1511 (1): 1393–1400. https://doi.org/10.1063/1.4789205 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search