gebhart/patrepeval huggingface dataset:
MicroDG: Distributed Data Retrieval & Generation through Microservices (2016)

The focus of the MicroDG project was to build a cloud-based system of microservices for the purpose of dynamically generating sales lead data. The system addresses the need for the automated bulk tagging of freely available business data with a variety of additional information such as geographical information. This type of task would normally be done manually which is neither time efficient nor financially viable for many businesses.

This project is also a study into the advantages of applying a microservice architecture pattern in partnership with a variety of programming languages and toolkits, in terms of system speed and scalability.

The system is currently in production using Scala, Akka, Spray and AngularJS amongst other technologies. A working prototype of this system is available for download and can be run in the local environment (please see Appendix E: User Manual, for further details).
Modeling Particle Spray and Capture Efficiency for Direct Laser Deposition Using a Four Nozzle Powder Injection System (2018)

Powder capture efficiency is indicative of the amount of material that is added to the substrate during laser additive manufacturing (AM) processes, and thus, being able to predict capture efficiency provides capability of predictive modeling during such processes. The focus of the work presented in this paper is to create a numerical model to understand particle trajectories and velocities, which in turn allows for the prediction of capture efficiency. To validate the numerical model, particle tracking velocimetry (PTV) experiments at two powder flow rates were conducted on free stream particle spray to track individual particles such that particle concentration and velocity fields could be obtained. Results from the free stream comparison showed good agreement to the trends observed in experimental data and were subsequently used in a direct laser deposition (DLD) simulation to assess capture efficiency and temperature profile at steady-state. The simulation was validated against a single track deposition experiment and showed proper correlation of the free surface geometry, molten pool boundary, heat affected zone boundary, and capture efficiency.
Layered Space-Time Ofdm With High-Performance And High-Rate (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation (2020)

Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the <i>N</i>-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal damage. The peptides NR2B9c and <i>N</i>-dimer have been designed to hinder this interaction; they are conjugated to the cell-penetrating peptide Tat to facilitate blood-brain barrier (BBB) permeation and neuronal uptake. Tat-<i>N</i>-dimer exhibits 1000-fold better target affinity than Tat-NR2B9c, but the same magnitude of improvement is not observed in terms of therapeutic effect. Differences in BBB permeation by Tat-NR2B9c and Tat-<i>N</i>-dimer may explain this difference, but studies providing a direct comparison of Tat-NR2B9c and Tat-<i>N</i>-dimer are lacking. The aim of the present study was therefore to compare the BBB uptake and permeation of Tat-NR2B9c and Tat-<i>N</i>-dimer. The peptides were conjugated to the fluorophore TAMRA and their chemical stability assessed. Endothelial membrane association and cell uptake, and transendothelial permeation were estimated using co-cultures of primary bovine brain capillary endothelial cells and rat astrocytes. In vivo BBB permeation was demonstrated in mice using two-photon microscopy imaging. Tissue distribution was evaluated in mice demonstrating brain accumulation of TAMRA-Tat (0.4% ID/g), TAMRA-Tat-NR2B9c (0.3% ID/g), and TAMRA-Tat-<i>N</i>-dimer (0.25% ID/g). In conclusion, we demonstrate that attachment of NR2B9c or <i>N</i>-dimer to Tat affects both the chemical stability and the ability of the resulting construct to interact with and permeate the BBB.
Regulation of the pR operon of bacteriophage lambda. (1983)

The E. coli lambda lysogen, OR1263, carries the fusion pR-cro-tR1-IS2-gal. The gal promoter is deleted and gal expression from pR, in the absence of the lambda antitermination factor N, is blocked by the efficient transcription terminator in IS2. Selection for Gal+ yields strains deleted for the IS2 terminator and various portions of the lambda chromosome. Analysis of these deletions reveals the following: (a) The lambda tR1 terminator is about 50% efficient. (b) In two deletions sequenced, DNA loss occurred as a result of homologous recombination between a 2- or a 4-base pair repeat. (c) By measuring the ability of lambda N product to suppress the polarity of a gal ochre mutation, we demonstrate that the N utilization site in the lambda pR operon lies between tR1 and cro. (d) The level of Cro repressor synthesized by a single copy prophage is sufficient to repress the cI maintenance promoter, prm, but is inadequate to inhibit pR.
Immunomodulatory Effects of Dietary Supplementation with a Milk-Based Wolfberry Formulation in Healthy Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial (2012)

Wolfberry (fruit of Lycium barbarum) has been prized for many years in China for its immunomodulatory property and its high specific antioxidant content. However, clear clinical evidence demonstrating the effect of wolfberry dietary supplementation is still lacking. After our earlier report showing that a proprietary milk-based wolfberry formulation (Lacto-Wolfberry) enhances in vivo antigen-specific adaptive immune responses in aged mice, the present study aimed at demonstrating the effect of dietary Lacto-Wolfberry supplementation on immune functions in the elderly, especially vaccine response known to decline with aging. A 3-month randomized, double-blinded, placebo-controlled study was conducted on 150 healthy community-dwelling Chinese elderly (65-70 years old) supplemented with Lacto-Wolfberry or placebo (13.7 grams/day). Immune response to influenza vaccine was assessed in the study, along with inflammatory and physical status. No serious adverse reactions were reported during the trial, neither symptoms of influenza-like infection. No changes in body weight and blood pressure, blood chemistry or cells composition, as well as autoantibodies levels were observed. The subjects receiving Lacto-Wolfberry had significantly higher postvaccination serum influenza-specific immunoglobulin G levels and seroconversion rate, between days 30 and 90, compared with the placebo group. The postvaccination positive rate was greater in the Lacto-Wolfberry group compared to the placebo group, but did not reach statistical significance. Lacto-Wolfberry supplementation had no significant effect on delayed-type hypersensitivity response and inflammatory markers. In conclusion, long-term dietary supplementation with Lacto-Wolfberry in elderly subjects enhances their capacity to respond to antigenic challenge without overaffecting their immune system, supporting a contribution to reinforcing immune defense in this population.
Supplementary Figure 1 from Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure 1. Comparison of AR, MYC, CCND1 and CCNE1 copy number status in 5 patients with matched circulating cell-free DNA and tumor biopsies subjected to array comparative genomic hybridization&lt;/p&gt;
<title>Parallel butterfly algorithm and VLSI architectures for image decorrelation</title> (1994)

We present a new high speed parallel architecture and its VLSI implementation to design a special purpose hardware for real-time lossless image compression/decompression using a decorrelation scheme. The proposed architecture can easily be implemented using state-of-the- art VLSI technology. The hardware yields a high compression rate. A prototype 1-micron VLSI chip based on this architectural idea has been designed. The scheme is favorably comparable to the JPEG baseline lossless image compression schemes. We also discuss the parallelization issues of the JPEG baseline standard still compression schemes and their difficulties.
Modeling of an active TV system for surveillance operations (1999)

Night vision capability has become an indispensable tool for military and civilian surveillance operations. Low-light- level television (LLLTV) and Forward-Looking-IR (FLIR) devices have long been used for these applications. Nevertheless, both have their shortcomings when the identification of the target is essential for the success of the mission. LLLTV cannot provide god image resolution in ultra low-light level conditions and is very sensitivity to parasitic light. FLIR system have poor resolution when the temperature difference contrast conditions are not met.
Dermatology for the House Officer (1988)

There is certainly a niche in the medical resident's bookcase for the second edition of Lynch's<i>Dermatology for the House Officer</i>. The problem that most internists have with dermatology is that there appears to be a mystifying number of extremely rare and portentous conditions that require great qualitative clinical expertise to accurately diagnose and treat. Of course, there is a certain amount of truth to this impression. Dr Lynch, however, contends that in clinical practice, more than 95% of dermatologic disease is accounted for in 75 common conditions. The heart of his book thus lies in a clinical algorithm that separates the aforementioned 75 diseases into ten groups. The ten groups, moreover, are formed on the basis of easily separable qualitative characteristics (eg, group VI, "yellow lesions," and group VII, "red papules and nodules," encompass 12 of the 75 common clinical conditions). This method of knowledge organization is easily
Selective Loss of Innate CD4+Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection (2002)

V alpha 24 natural killer T (NKT) cells are innate immune cells involved in regulation of immune tolerance, autoimmunity, and tumor immunity. However, the effect of human immunodeficiency virus type 1 (HIV-1) infection on these cells is unknown. Here, we report that the V alpha 24 NKT cells can be subdivided into CD4(+) or CD4(-) subsets that differ in their expression of the homing receptors CD62L and CD11a. Furthermore, both CD4(+) and CD4(-) NKT cells frequently express both CXCR4 and CCR5 HIV coreceptors. We find that the numbers of NKT cells are reduced in HIV-infected subjects with uncontrolled viremia and marked CD4(+) T-cell depletion. The number of CD4(+) NKT cells is inversely correlated with HIV load, indicating depletion of this subset. In contrast, CD4(-) NKT-cell numbers are unaffected in subjects with high viral loads. HIV infection experiments in vitro show preferential depletion of CD4(+) NKT cells relative to regular CD4(+) T cells, in particular with virus that uses the CCR5 coreceptor. Thus, HIV infection causes a selective loss of CD4(+) lymph node homing (CD62L(+)) NKT cells, with consequent skewing of the NKT-cell compartment to a predominantly CD4(-) CD62L(-) phenotype. These data indicate that the key immunoregulatory NKT-cell compartment is compromised in HIV-1-infected patients.
Tapered Multi-Mode Interference Waveguide for High-Power Self-Organizing Single-Mode Semiconductor Laser Arrays (2011)

A 1 × N, tapered, multi-mode interference (MMI) coupler is numerically studied for use in a self-organizing semiconductor laser-array system. The MMI structure is linearly tapered in a way such that the single-port side is wider than the N-port side. The single-port waveguide is N times wider than the other ports to maintain intensity similar to that in each of the N-port waveguides. Using such a device, the N-ports of a semiconductor laser array can be coherently combined in a self-organizing architecture. This modified MMI design increases the output power threshold for catastrophic optical damage while maintaining only single-mode excitation of a wide single port output. The device is nonadiabatic with a single-pass power transmission of 98%. A power imbalance up to 40% in a single port reduces the device efficiency by less than 1%, while a waveguide roughness as large as 70 nm rms detracts only 3% from the device efficiency. When designed to work at 1 μm wavelength, the structure has a full-width half-maximum pass-band of 10 nm, which can provide wavelength selectability when used in a self-organized semiconductor laser-array system.
Supplementary Table S2 from Molecular Analysis of Plasma DNA for the Early Detection of Lung Cancer by Quantitative Methylation-Specific PCR (2023)

&lt;p&gt;Supplementary Table S2.&lt;/p&gt;
Evidence of Zintl Intermediate Phase and Its Impacts on Li and Na Storage Performance of Pb-Based Alloying Anodes (2023)

Anode materials based on conversion and alloying reactions are promising to achieve high energy density of advanced sodium-ion batteries (SIBs). While the chemical similarities between sodium and lithium as alkali elements make the benchmarking strategy practical in developing new high-performance anodes, simply borrowing the anode material from one system to the other does not always guarantee success unless it is based on sound understanding of both Li- and Na-reaction mechanisms. In this work, we report the Na storage performance of a Pb-based anode and its fundamental reaction dynamics. In contrast to its excellent electrochemical performances in Li cells (reversible ∼600 mAh/g), the newly developed Pb@PbO–C nanocomposite anode has limited electrochemical Na reaction properties showing moderate capacity and rate performances (∼300 mAh/g at 20 mA/g). Synchrotron-based X-ray diffraction and absorption spectroscopy studies reveal the fundamental differences in the Na and Li reaction mechanism of the Pb-based anode. Unlike Li reaction, the unique Na reaction mechanism involves the formation of a highly ionic NaPb Zintl phase, which comprises tetrahedral Pb4 clusters, as an intermediate phase. The strong covalent character of the Pb4 Zintl clusters adversely affects the electronic conductivity and thus limits the electrochemical performance of the Pb-based anode in Na cells. These findings provide new insights applicable to developing high-performance alloying anode materials.
Engineered Pseudomonas putida simultaneously catabolizes five major components of corn stover lignocellulose: Glucose, xylose, arabinose, p-coumaric acid, and acetic acid (2020)

Valorization of all major lignocellulose components, including lignin, cellulose, and hemicellulose is critical for an economically viable bioeconomy. In most biochemical conversion approaches, the standard process separately upgrades sugar hydrolysates and lignin. Here, we present a new process concept based on an engineered microbe that could enable simultaneous upgrading of all lignocellulose streams, which has the ultimate potential to reduce capital cost and enable new metabolic engineering strategies. Pseudomonas putida is a robust microorganism capable of natively catabolizing aromatics, organic acids, and D-glucose. We engineered this strain to utilize D-xylose by tuning expression of a heterologous D-xylose transporter, catabolic genes xylAB, and pentose phosphate pathway (PPP) genes tal-tkt. We further engineered L-arabinose utilization via the PPP or an oxidative pathway. This resulted in a growth rate on xylose and arabinose of 0.32 h<sup>-1</sup> and 0.38 h<sup>-1</sup>, respectively. Using the oxidative L-arabinose pathway with the PPP xylose pathway enabled D-glucose, D-xylose, and L-arabinose co-utilization in minimal medium using model compounds as well as real corn stover hydrolysate, with a maximum hydrolysate sugar consumption rate of 3.3 g/L/h. After modifying catabolite repression, our engineered P. putida simultaneously co-utilized five representative compounds from cellulose (D-glucose), hemicellulose (D-xylose, L-arabinose, and acetic acid), and lignin-related compounds (p-coumarate), demonstrating the feasibility of simultaneously upgrading total lignocellulosic biomass to value-added chemicals.
Design of A Multi-Path Reconfigurable Traffic Monitoring System (2021)

As network bandwidth consumption continues to grow exponentially, real-time traffic data analysis becomes increasingly challenging and expensive. In many cases, network traffic monitoring can only be achieved via hardware Test Access Point (TAP) devices. Due to the intrusiveness and inflexibility of deploying hardware devices, this approach is intractable within an SDN environment where dynamic network resource allocation is key to the orchestration of network services. This paper presents a novel mirror tunnel design to achieve near hardware level TAP-as-a-Service (TaaS) performance through network device mirror offloading, while retaining resource reconfigurability. Mirror tunneling is a hybrid approach whereby a software TAP transports traffic from a source device to a mirror tunnel device. Traffic is then mirrored in place and sent to the destination device. The combination of a software TAP with the mirroring capabilities of the underlying hardware empowers system administrators to create a dynamically reconfigurable multi-path traffic mirroring system. As demonstrated in the benchmark results, this approach is efficient in terms of network bandwidth consumption and computational resources. In addition, this methodology is designed to mirror traffic in high-throughput environments with minimal to no impact on the source Virtual Network Functions (VNFs).
ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells (2012)

SATB1 drives metastasis when expressed in breast tumor cells by radically reprogramming gene expression. Here, we show that SATB1 also has an oncogenic activity to transform certain non-malignant breast epithelial cell lines. We studied the non-malignant MCF10A cell line, which is used widely in the literature. We obtained aliquots from two different sources (here we refer to them as MCF10A-1 and MCF10A-2), but found them to be surprisingly dissimilar in their responses to oncogenic activity of SATB1. Ectopic expression of SATB1 in MCF10A-1 induced tumor-like morphology in three-dimensional cultures, led to tumor formation in immunocompromised mice, and when injected into tail veins, led to lung metastasis. The number of metastases correlated positively with the level of SATB1 expression. In contrast, SATB1 expression in MCF10A-2 did not lead to any of these outcomes. Yet DNA copy-number analysis revealed that MCF10A-1 is indistinguishable genetically from MCF10A-2. However, gene expression profiling analysis revealed that these cell lines have significantly divergent signatures for the expression of genes involved in oncogenesis, including cell cycle regulation and signal transduction. Above all, the early DNA damage-response kinase, ATM, was greatly reduced in MCF10A-1 cells compared to MCF10A-2 cells. We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two other non-malignant breast epithelial cell lines, 184A1 and 184B4, enabled SATB1 to induce malignant phenotypes similar to that observed for MCF10A-1. These data indicate a novel role for ATM as a suppressor of SATB1-induced malignancy in breast epithelial cells, but also raise a cautionary note that phenotypic drift could lead to dramatically different functional outcomes.
Latency Aware 3D Placement and User Association in Drone-Assisted Heterogeneous Networks With FSO-Based Backhaul (2021)

Drone Base Station (DBS) is expected to play an important role in next generation cellular networks due to its maneuverability in establishing air-to-ground Line of Sight (LoS) links. Working as a mobile relay node between the Macro Base Station (MBS) and the ground users, the DBS can significantly reduce the latency of ground users by offloading traffic loads from the MBS to the DBS since a better channel condition can be provided. In this paper, we focus on how to determine the 3D location of the DBS, the user association and the bandwidth allocation policy between the MBS and the DBS in order to minimize the total average latency ratio of all users with the constraint of each user's QoS requirement and total available bandwidth. The formulated problem is a mixed integer nonconvex optimization problem, a very challenging and difficult problem. We propose a cyclic iterative algorithm to efficiently solve it by decomposing the primal problem into two subproblems, i.e., the user association and bandwidth allocation problem and the 3D DBS placement problem. In each iteration, the two sub-problems are alternatively optimized by using the output of one as the input for the other. Numerical simulation results demonstrate the significant latency ratio reduction of our proposed algorithm as compared to other baseline schemes.
TUNNELING IN DIBORANE-HYDROGEN CHLORIDE DIMERS$^{\ast}$ (1987)

$^{\ast}$ Work supported by NSF and PRF. $^{1}$ H.S. Gutowsky, T. Emilsson, J.D. Keen, J.D. Klots, and C. Chuang, J. Chem. Phys. 85, 683 (1986).
Synthesis and Screening of Phase Change Chalcogenide Thin Film Materials for Data Storage (2017)

A combinatorial synthetic methodology based on evaporation sources under an ultrahigh vacuum has been used to directly synthesize compositional gradient thin film libraries of the amorphous phases of GeSbTe alloys at room temperature over a wide compositional range. An optical screen is described that allows rapid parallel mapping of the amorphous-to-crystalline phase transition temperature and optical contrast associated with the phase change on such libraries. The results are shown to be consistent with the literature for compositions where published data are available along the Sb<sub>2</sub>Te<sub>3</sub>-GeTe tie line. The results reveal a minimum in the crystallization temperature along the Sb<sub>2</sub>Te<sub>3</sub>-Ge<sub>2</sub>Te<sub>3</sub> tie line, and the method is able to resolve subsequent cubic-to-hexagonal phase transitions in the GST crystalline phase. HT-XRD has been used to map the phases at sequentially higher temperatures, and the results are reconciled with the literature and trends in crystallization temperatures. The results clearly delineate compositions that crystallize to pure GST phases and those that cocrystallize Te. High-throughput measurement of the resistivity of the amorphous and crystalline phases has allowed the compositional and structural correlation of the resistivity contrast associated with the amorphous-to-crystalline transition, which range from 5-to-8 orders of magnitude for the compositions investigated. The results are discussed in terms of the compromises in the selection of these materials for phase change memory applications and the potential for further exploration through more detailed secondary screening of doped GST or similar classes of phase change materials designed for the demands of future memory devices.
4×112 Gbps/fiber CWDM VCSEL Arrays for Co-Packaged Interconnects (2020)

We demonstrate a 4×112 Gbps/fiber VCSEL link using a co-packaged coarse wavelength division multiplexing (CWDM) optical module. A complete co-packaged CWDM module can achieve a 2.668 Tb/s aggregated bandwidth by assembling four 1×6 VCSEL arrays.