gebhart/patrepeval huggingface dataset:
Simulation, Fabrication and Characterization of 4H-SiC Floating Junction Schottky Barrier Diodes (Super-SBDs) (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Ligand-free, palladacycle-facilitated Suzuki coupling of hindered 2-arylbenzothiazole derivatives yields potent and selective COX-2 inhibitors (2017)

A similarity search and molecular modeling study suggested the 2'-aryl-2-arylbenzothiazole framework as a novel scaffold for the design of COX-2-selective inhibitors. Conventional Suzuki coupling conditions did not furnish the designed compounds in good yield from 2'-bromo-2-arylbenzothiazole as the starting material. A novel ligand-free Suzuki-Miyaura coupling methodology was developed for sterically hindered 2'-bromo-2-arylbenzothiazoles. The reaction depends on the coordination properties of the benzothiazole ring nitrogen, which is involved in the formation of a palladacyclic intermediate that was synthesized independently and converted to the final product. The new method provides good to excellent yields (up to 99%) with favorable functional group tolerability. Six compounds had potencies in the submicromolar range against COX-2 and higher selectivity for COX-2 vs. COX-1 compared to the currently used drug celecoxib. Molecular modeling was used to investigate the possible binding mode with COX-2.
CHAPTER 13. Peptide Therapeutics: Neuropeptides (2017)

The development of neuropeptide therapeutics poses several difficulties, including stability, bioavailability, receptor selectivity, and the ability (or not) to cross membrane barriers. In this chapter we discuss briefly the efforts that are being made to address these problems using selective examples for the melanocortin, bradykinin and opioid systems. The use of conformational constraint, topographical constraint, and computational approaches to ligand design, including ligand–receptor homology modeling are discussed as an approach to enhance the properties of peptides for the development of peptide therapeutics.
Notch1 Mutations in Adult T Lymphoblastic Lymphoma and T-ALL. (2006)

Abstract Notch1 is recognised to be involved in human T-ALL oncogenesis, initially by implication of its intracellular domain in the rare translocation t(7;9) and more recently with the description of mutations in NOTCH1 exons coding the heterodimerisation (HD) +/− PEST domains in 50% of T-ALL. Favorable prognosis impact of Notch1 mutations has been shown in pediatric patients. Little data is available regarding Notch mutations in adult T-ALL, and even less in adult T Lymphoblastic lymphoma (T-LBL). We have therefore searched for Notch1 mutations in adult T-ALL and T-LBL, all of which have undergone comparable, TCR and oncogene based classification (TLX1/3, SIL-TAL1, CALM-AF10, LMO1/2, TAL1 and LYL1). We searched for mutations in exons 26, 27 and 34 by direct sequencing in 46 T-ALL (median age 27,5y. range 16–54; 6 &lt; 18y) and 32 T-LL (median 31y., range 16–70y.; 3 &lt; 18y.). Notch1 mutations were identified in 22/46 (48%) of T-ALL and 16/32 (50%) of T-LBL. The type of mutations differed, insofar as HD only mutations were seen in 16/22 (73%) of mutated T-ALL but only 4/16 (25%) of mutated T-LL whereas PEST only mutations were seen in 2/22 (9%) T-ALL compared to 8/16 (50%) of T-LBL. The incidence of HD and PEST mutations was identical in T-ALL (4/16; 25%) and T-LBL (6/22; 27%). Combining T-ALL and T-LBL, TLX1hi or TLX3 expression was seen in 7/71 (10%) and 5/71 (7%) cases respectively. Notch1 mutations were seen in 7/7 TLX1+ cases but only 1/5 TLX3 (p=0.004). With respect to stage of maturation arrest, Notch mutations in T-ALL were relatively rare in mature TCR+ cases (2/15 vs. 20/31 p=0.001), whereas they were found at all stages of maturation arrest in T-LBL. These data demonstrate that Notch 1 mutations are as frequent in T-LBL as T-ALL, but more frequently involve the PEST domain. They are in favour of preferential occurrence of NOTCH1 mutations in TLX1 relative to TLX3 proliferations, suggesting that evaluation of prognostic impact of Notch1 should not be performed independently of evaluation of TLX1/3 status, since TLX1 generally identifies good prognosis and TLX3 poor prognosis T-ALL. Within the 46 LALA94 adult T-ALLs, Notch1 mutated cases were of marginally superior prognosis (p=0.50); this is currently being evaluated within the ongoing adult GRAALL03 T-ALL trial.
Polyisoprene Composites with Conductive Tubular Nanostructures for Multifunctional Sensing: Fabrication and Properties (2010)

Recent achievements of scientific group of Riga Technical University in&#13;\ncollaboration with COINAPO partners in design, processing and investigation of&#13;\npolyisoprene composites with conductive tubular nanostructures (PCCTN) as prospective&#13;\nmaterials for completely hyper-elastic (non-rigid) mechanical (pressure, strain)&#13;\nindicators, chemical vapour indicators as well as temperature indicators have been&#13;\npresented. Non-rigid multifunctional sensing materials attract attention of scientists and&#13;\nengineers because of potential possibility to incorporate them in different solid and&#13;\nnonsolid systems for specific parameter control.&#13;\nPrevious experience with electro-active materials like ferroelectrics suggests that&#13;\nmaximum sensitivity of material to any influence is observed in the vicinity of phase&#13;\ntransitions. The percolation transition in PCCTN could be imagined as specific phase&#13;\ntransition from electrically insulating state to electrically conductive state. Thus, the&#13;\nmaximum sensitivity of PCCTN materials to external thermodynamic forces (ETF)&#13;\nshould be expected in the vicinity of percolation threshold. The reversibility of material&#13;\nreaction to ETF should be achieved by positioning conductive tubular nanostructures in&#13;\nthe spatial grid by curing of hyper-elastic polymer matrix.&#13;\nOur previous research approved that high structure carbon black PRINTEX XE2&#13;\nfilled composites demonstrate finger pressure sensitive piezoresistivity as well as good&#13;\norganic solvent vapour sensing. Conductive tubular nanostructures originate with variable&#13;\nlength to width ratio and high electric conductivity in longitudinal direction of the tubes,&#13;\nwhich theoretically should make it possible to obtain electric percolation in polymercarbon&#13;\nnanotube composites at very low loads of filler. However recent experience with&#13;\nmechanically dispersed carbon nanotubes shows quite high values of percolation&#13;\nthreshold and specific sensing properties.&#13;\nIn this work we present an attempt to use ultrasound for improved dispersion of&#13;\nthe filler in polyisoprene matrix composite. Multi wall carbon nanotubes (MWCNT)&#13;\n“Aldrich 636835” as well as inorganic nanotubules (IN) Mo6S2I8 and MoO3-X are used as&#13;\nfiller. As reference filler PRINTEX XE2 was also used.&#13;\nThe noticeable shifting of percolation threshold to lower values of concentration has&#13;\nbeen achieved for all types of nano-composites. The piezoresistive and chemosensitive&#13;\nbehaviour of sonicated nano-composites have been determined and compared with&#13;\nmechanically mixed ones. The obtained results are explained using quantum mechanical&#13;\ncharge tunnelling and percolation theory.
Improved Filler-Matrix Coupling in Resin Composites (2002)

Ineffective silane coupling between filler and matrix within dental composites is prone to accelerated in vivo degradation. In this study, we examined to what degree a procedure involving chemical decontamination of filler prior to silanization could improve the filler-matrix bonding, and thus the physico-mechanical properties, of composites. X-ray photoelectron spectroscopy revealed that filler-matrix coupling largely depended upon siloxane bridge (Si-O-Si) formation between the silica surface and the silane molecule, rather than on intermolecular bonding between adjacent silane molecules. Pre-silanization decontamination based upon boiling silica in 0.05-5% sodium peroxodisulfate, followed by ultrasonic rinsing in acetone, most effectively decontaminated filler. Consequently, it significantly improved the bonding of silane molecules to silanol groups at the silica surface. Experimental composites produced following pre-silanization decontamination of filler revealed a diametral tensile strength that was resistant to degradation by thermocycling.
A Simple Equation of State Valid in the Critical Region for Pure Compounds (1998)

A simple, analytic expansion about the critical point appears capable of adequate representation for the compression factor in the single phase region near the critical point. The equation requires TC, PC, VC, and ω to predict the compression factor, and we have used it to represent the behavior of argon, carbon dioxide, ethene, methane, and nitrogen. The scaling hypothesis would indicate that this expansion is invalid; however, the best available data seem to be susceptible of such treatment. The equation can also represent phase behavior in the critical region by utilizing it with the Maxwell criterion.
Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway (2016)

Berberine (BBR) has been shown to exhibit protective effects against diabetes and dyslipidemia. Previous studies have indicated that BBR modulates lipid metabolism and inhibits hepatic gluconeogensis by decreasing expression of Hepatocyte Nuclear Factor-4α (HNF-4α). However, the mechanism involved in this process was unknown. In the current study, we examined the mechanism of how BBR attenuates hepatic gluconeogenesis and the lipid metabolism alterations observed in type 2 diabetic (T2D) mice and in palmitate (PA)-incubated HepG2 cells. Treatment with BBR for 4 weeks improve all biochemical parameters compared to T2D mice. Treatment of T2D mice for 4 weeks or treatment of PA-incubated HepG2 cells for 24 h with BBR decreased expression of HNF-4α and the microRNA miR122, the key gluconeogenesis enzymes Phosphoenolpyruvate carboxykinase (PEPCK) and Glucose-6-phosphatase (G6Pase) and the key lipid metabolism proteins Sterol response element binding protein-1 (SREBP-1), Fatty acid synthase-1 (FAS-1) and Acetyl-Coenzyme A carboxylase (ACCα) and increased Carnitine palmitoyltransferase-1(CPT-1) compared to T2D mice or PA-incubated HepG2 cells. Expression of HNF-4α in HepG2 cells increased expression of gluconeogenic and lipid metabolism enzymes and BBR treatment or knock down of miR122 attenuated the effect of HNF-4α expression. In contrast, BBR treatment did not alter expression of gluconeogenic and lipid metabolism enzymes in HepG2 cells with knockdown of HNF-4α. In addition, miR122 mimic increased expression of gluconeogenic and lipid metabolism enzymes in HepG2 cells with knockdown of HNF-4α. These data indicate that miR122 is a critical regulator in the downstream pathway of HNF-4α in the regulation of hepatic gluconeogenesis and lipid metabolism in HepG2 cells. The effect of BBR on hepatic gluconeogenesis and lipid metabolism is mediated through HNF-4α and is regulated downstream of miR122. Our data provide new evidence to support HNF-4α and miR122 regulated hepatic gluconeogenesis and lipid metabolism as promising therapeutic targets for the treatment of T2D.
The Δ F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis–Like Disease in Pigs (2011)

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. The most common CF-associated mutation is ΔF508, which deletes a phenylalanine in position 508. In vitro studies indicate that the resultant protein, CFTR-ΔF508, is misprocessed, although the in vivo consequences of this mutation remain uncertain. To better understand the effects of the ΔF508 mutation in vivo, we produced CFTR(ΔF508/ΔF508) pigs. Our biochemical, immunocytochemical, and electrophysiological data on CFTR-ΔF508 in newborn pigs paralleled in vitro predictions. They also indicated that CFTR(ΔF508/ΔF508) airway epithelia retain a small residual CFTR conductance, with maximal stimulation producing ~6% of wild-type function. Cyclic adenosine 3',5'-monophosphate (cAMP) agonists were less potent at stimulating current in CFTR(Δ)(F508/)(Δ)(F508) epithelia, suggesting that quantitative tests of maximal anion current may overestimate transport under physiological conditions. Despite residual CFTR function, four older CFTR(ΔF508/ΔF508) pigs developed lung disease similar to human CF. These results suggest that this limited CFTR activity is insufficient to prevent lung or gastrointestinal disease in CF pigs. These data also suggest that studies of recombinant CFTR-ΔF508 misprocessing predict in vivo behavior, which validates its use in biochemical and drug discovery experiments. These findings help elucidate the molecular pathogenesis of the common CF mutation and will guide strategies for developing new therapeutics.
Supplemental Figure S2 from Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages (2023)

&lt;p&gt;SEMA3AS EFFECT ON MONOCYTES AND MACROPHAGES.&lt;/p&gt;
The combined effects of iron, cobalt and nickel additions on anaerobicco-digestion of food and slaughterhouse waste (2014)

The combined effects of iron, cobalt and nickel additions on anaerobicco-digestion of food and slaughterhouse waste
Cost modeling and evaluation of capital expenditures in optical multilayer networks (2008)

Optical multilayer networks offer a high degree of freedom in network design, adapting to actual network requirements (demand types, topologies, etc.) and achieving cost-efficient realizations. Capital expenditures are one of the key differentiators for the evaluation of multilayer networks. A realistic cost model for Internet protocol/multiprotocol label switching (IP/MPLS), carrier-grade Ethernet, synchronous digital hierarchy/optical transport network (SDH/OTN), and WDM equipment from which overall capital expenditures can consistently be derived is contributed and discussed. A comprehensive collection of detailed cost values for different equipment types is presented. Furthermore, the cost model is applied to two case studies, one IP/MPLS-over-WDM study and one WDM study with two topologies, showing substitution effects of network elements to achieve overall capital expenditure minimization.
Eruptive Cycle and Bubble Trap of Strokkur Geyser, Iceland (2021)

Abstract The eruption frequency of geysers can be studied easily on the surface. However, details of the internal structure including possible water and gas filled chambers feeding eruptions and the driving mechanisms often remain elusive. We used a multidisciplinary network of seismometers, video cameras, water pressure sensors and one tiltmeter to study the eruptive cycle, internal structure, and mechanisms driving the eruptive cycle of Strokkur geyser in June 2018. An eruptive cycle at Strokkur always consists of four phases: (1) Eruption, (2) post‐eruptive conduit refilling, (3) gas filling of the bubble trap, and (4) regular bubble collapse at shallow depth in the conduit. For a typical single eruption 19 ± 4 bubble collapses occur in Phase 3 and 8 ± 2 collapses in Phase 4 at a mean spacing of 1.52 ± 0.29 and 24.5 ± 5.9 s, respectively. These collapses release latent heat to the fluid in the bubble trap (Phase 3) and later to the fluid in the conduit (Phase 4). The latter eventually reaches thermodynamic conditions for an eruption. Single to sextuple eruptions have similar spacings between bubble collapses and are likely fed from the same bubble trap at 23.7 ± 4.4 m depth, 13–23 m west of the conduit. However, the duration of the eruption and recharging phase linearly increases likely due to a larger water, gas and heat loss from the system. Our tremor data provides documented evidence for a bubble trap beneath a pool geyser.
Compact, Fast Access Optical Image Correlator Using Orthogonal Data Storage (1993)

A compact optical correlator with fast accessability using Fourier transform orthogonal data storage holography is described. Cross-correlation and auto-correlation measurements are also presented.
Basic studies on the inifer mechanism, 2. Interaction of 1,4‐bis(1‐methoxy‐1‐methylethyl)benzene with BCl3 in CH2Cl2 (1992)

Abstract 1,4‐Bis(1‐methoxy‐1‐methylethyl)benzene is a representative of a novel generation of inifers, ini tiator/trans fer agents for cationic polymerizations. In contrast to the classical initiator 1,4‐bis(1‐chloro‐1‐methylethyl)benzene its activation needs an excess of BCl 3 . This behavior is closely related to a complex formation between the ether and BCl 3 . On the basis of combined UV/VIS and conductivity measurements a mechanism for the ion formation is suggested.
UNIVERSALITY IN THE GRAVITATIONAL STRETCHING OF CLOCKS, WAVES AND QUANTUM STATES (2011)

There are discernible and fundamental differences between clocks, waves and physical states in classical physics. These fundamental concepts find a common expression in the context of quantum physics in gravitational fields; matter and light waves, quantum states and oscillator clocks become quantum synonymous through the Planck–Einstein–de Broglie relations and the equivalence principle. With this insight, gravitational effects on quantum systems can be simply and accurately analyzed. Apart from providing a transparent framework for conceptual and quantitative thinking on matter waves and quantum states in a gravitational field, we address and resolve with clarity the recent controversial discussions on the important issue of the relation and the crucial difference between gravimetery using atom interferometers and the measurement of gravitational time dilation.
Two Dimensional Dopant Profiling by Scanning Tunneling Microscopy (2011)

Recent progress in two-dimensional doping profile measurements on silicon with scanning tunneling microscopy and spectroscopy (STM/STS) is presented. STM spectroscopy modes described are constant-current imaging, onset voltage profiling, vacuum-gap modulation spectroscopy and resonant-electron-tunneling spectroscopy with a marker molecule. These modes employ dependence of tunneling current on dopant type and concentration through the band bending induced by the metal STM tip at the surface. The combination of multiple spectroscopy modes and complimentary simulations makes the STM/STS as a powerful instrument for Si device characterization with the ability to observe the surface potential and location of individual dopant atoms on flat and electrically inert Si surfaces. Actual measurements are demonstrated for both the oxidized surfaces and the hydrogen-terminated Si(111) surface. Carrier concentration maps of small Si devices are shown. The mechanism of the measurements is discussed.
Distortion matrix approach for ultrasound imaging of random scattering media (2020)

Focusing waves inside inhomogeneous media is a fundamental problem for imaging. Spatial variations of wave velocity can strongly distort propagating wave fronts and degrade image quality. Adaptive focusing can compensate for such aberration but is only effective over a restricted field of view. Here, we introduce a full-field approach to wave imaging based on the concept of the distortion matrix. This operator essentially connects any focal point inside the medium with the distortion that a wave front, emitted from that point, experiences due to heterogeneities. A time-reversal analysis of the distortion matrix enables the estimation of the transmission matrix that links each sensor and image voxel. Phase aberrations can then be unscrambled for any point, providing a full-field image of the medium with diffraction-limited resolution. Importantly, this process is particularly efficient in random scattering media, where traditional approaches such as adaptive focusing fail. Here, we first present an experimental proof of concept on a tissue-mimicking phantom and then, apply the method to in vivo imaging of human soft tissues. While introduced here in the context of acoustics, this approach can also be extended to optical microscopy, radar, or seismic imaging.
Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation: Can we restore default mode network function for therapeutic benefit? (2021)

This case raises important questions regarding the clinical utility of transcranial magnetic stimulation to improve the connectivity of important cerebral networks and subsequent related functional recovery.
A 1000 word speech recognition system using a special purpose CMOS-processor (1987)

This paper describes a speech recognition system for speaker dependent isolated word recognition. The system consists essentially of two processing boards: a feature extraction board using a TMS320C25 signal processor, and a patternmatehing board involving a special purpose CMOS-processor capable of matehing with up to 1000 words in real time. A 80186 microprocessor, also contained on the pattern matehing board, provides control and data transfer between the speech recognition system and an arbitrary host computer.
Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells. Evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool (1991)

D-myo-Inositol (1,4,5)-trisphosphate ((1,4,5)IP3)-induced Ca2+ release and subsequent Ca2+ reuptake were investigated in saponin-permeabilized rat parotid acinar cells. Following the rapid release of Ca2+ by (1,4,5)IP3, Ca2+ was resequestered. The sequential addition of submaximal concentrations of (1,4,5)IP3 resulted in sequential Ca2+ release. However, when the cells were challenged with the poorly metabolized (1,4,5)IP3 analogues, (1,4,5)IPS3 or (2,4,5)IP3, or under conditions where the metabolism of authentic (1,4,5)IP3 was reduced, Ca2+ reuptake again occurred, but sequestered Ca2+ was not released by subsequent additions of (1,4,5)IP3. The sequestered Ca2+ was, however, released by thapsigargin, an agent which inhibits active Ca2+ uptake into the (1,4,5)IP3-sensitive pool. Furthermore, the rate of thapsigargin-induced release was significantly increased in the continued presence of an (1,4,5)IP3 stimulus. Thus, Ca2+ reuptake apparently occurred into the (1,4,5)IP3- and thapsigargin-sensitive Ca2+ store and (1,4,5)IP3 continued to influence the permeability of this pool to Ca2+ during Ca2+ reuptake. In contrast to the findings in permeabilized cells, Ca2+ reuptake did not occur in the sustained presence of (1,4,5)IP3 in intact parotid cells. We conclude that cell permeabilization reveals a kinetic, and presumably structural, separation of Ca2+ uptake and release sites within the (1,4,5)IP3-regulated intracellular organelle.