gebhart/patrepeval huggingface dataset:
Development of a novel intervention diagnostic assay for managing bladder cancer survivors using urinary biomarkers (2008)

22097 Background: With increasing therapeutic efficacies and improved methods for early detection, the cancer survivor population has been growing steadily. As this population grows, there is a clear need for the development of more effective clinical algorithms and assays that would result in more efficient management of cancer survivors. Bladder cancer survivors typically undergo cystoscopy screening at predetermined intervals over several years as standard of care. Although the majority of patients have a high likelihood of recurrence over their lifetime, only a small percentage of the population will have recurred at the time of a scheduled cystoscopy. Therefore, the development of a triage monitoring assay with extremely high Negative Predictive Value, would identify patients undergoing unnecessary cystoscopy, resulting in more efficient and appropriate application of cyctoscopy. Our group is developing a non-invasive urinary Clinical Intervention Determining Diagnostic (CIDD) test utilizing matrix metalloproteinases (e.g. MMP-2, MMP-9). Detection of matrix metalloproteinases in the urine of cancer patients has been shown to correlate with disease status in a variety of cancers, including bladder cancer. Methods: Urine samples were collected by clean catch or catherization and stored in aliquots at −80°C. Samples from 83 bladder cancer patients and 453 cancer-free individuals were analyzed via ELISA and zymography to determine the levels of MMP-2 and MMP-9. Results: Initial studies using urinary levels of MMP-2 and MMP-9 to discriminate disease-free patients from those with bladder cancer resulted in approximately 81% (67/83) sensitivity and 71% (321/453) specificity at a fixed protein level. However, applying our proprietary CIDD algorithm correctly identified 51% (231/453) of patients who were cystoscopy negative with a Negative Predictive Value of 97% (231/231+6). Conclusion: Development of a non-invasive urinary diagnostic assay utilizing MMPs and a novel analytical algorithm can result in more efficient management of bladder cancer survivors by reducing the number of unnecessary cystocopies (51%) performed during recurrence monitoring, allowing the physician to more aggressively monitor high risk patients. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Predictive Biosciences Predictive Biosciences
A Microshield RF MEMS Shunt Switch (2006)

We propose a capacitive shunt switch based on the inverted microshield transmission line. A 0.1 mumm thick aluminum nitride film covering an area of 149.1 times 150 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> can be deposited on the signal metal strip. A thin gold beam of thickness 1.5 mum, width of 150 mum and length of 370 mum is fixed on both ends with two gold anchors of height 3 mum. We performed FEM simulations on the MEMS switch with HFSS. The scattering parameters of open and closed MEMS shunt switch. The insertion loss is less than 0.94 dB and the isolation is about 80 dB around 35 GHz. The capacitive MEMS shunt switch based on the inverted microshield line can be fabricated with low resistivity silicon. It has excellent high frequency performance and it has some advantages over conventional microshield transmission lines (Dib and Katehi, 1992)
Synthesis and thermal behavior of phenylethynyl‐terminated linear and hyperbranched polyphenylquinoxalines (2004)

Abstract A phenylquinoxaline (PQ) AB monomer mixture was treated with monofunctional and difunctional end‐capping agents and with and without a coupling agent to afford phenylethynyl‐terminated linear PQ oligomers. The resulting PQ oligomers were soluble in common organic solvents and had intrinsic viscosities (IVs) of 0.21–0.30 dL/g. The glass‐transition temperature ( T g ) of the diphenylethynyl‐end‐capped PQ oligomer on both sides increased the most, from 215 °C (before curing) to 251 °C (after curing). The PQ AB 2 monomer, which acted as both a coupling agent and a monomer for the hyperbranched polymer, was treated with an AB monomer and end‐capping agents to afford phenylethynyl‐terminated hyperbranched polyphenylquinoxalines (PPQs). They were also soluble in common organic solvents, had IVs of 1.00–1.65 dL/g and T g 's of 251–253 °C, and underwent exothermic cure with maxima around 412–442 °C. The T g 's of the cured hyperbranched PPQs ranged from 258 to 261 °C, depending on the number of phenylethynyl groups on the surface. After further curing, they displayed a T g of 316 °C in one sample and turned into a fully crosslinked network. The dynamic melt viscosities of a linear oligomer (IV = 0.21 dL/g), a hyperbranched sample (IV = 1.00 dL/g), and a linear reference PPQ (IV = 1.29 dL/g) were compared with respect to the processing temperature. The PQ oligomer and hyperbranched PPQ had low melt viscosities. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 6318–6330, 2004
End-to-End QoS control architectures from a wholesale and retail perspective: benefits and challenges (2006)

Godkänd; 2006; 20150819 (uffe)
Staphylococcal Enterotoxin‐A‐Induced In‐Vitro Adhesion of HL‐60 Cells to Endothelial Cells Involves both Selectin and Integrin Families of Cell Adhesion Molecules (1998)

In-vivo exposure to the bacterial superantigen Staphylococcal enterotoxin-A (SEA) induces an inflammatory response characterized by rapid extravasation of leucocytes and release of excessive amounts of cytokines. We have utilized an in-vitro adhesion assay to understand the molecular mechanisms responsible for SEA-induced extravasation of leucocytes. Stimulation of human umbilical cord endothelial cells (HUVEC) with increasing concentrations of recombinant SEA (rSEA) did not influence the in-vitro adhesion of HL-60 cells to HUVEC, whereas stimulation of HUVEC by interleukin (IL)-1beta supported adhesion of HL-60 cells. Increased adhesion of HL-60 cells to HUVEC was noted upon stimulation of endothelium with culture medium obtained from human peripheral blood mononuclear cells (PBM) stimulated with recombinant SEA for 24 (CM-SEA 24 h), 72 (CM-SEA 72 h) and 120 h (CM-SEA 120 h), but not after stimulation with culture medium obtained from control human peripheral blood mononuclear cells (CM), suggesting that soluble factors present in the supernatants play a major role in SEA-induced cell adhesion. While CM-SEA 24 and 72 h induced both a rapid (4 h) and delayed type of adhesion, CM-SEA 120 h only induced a delayed type of adhesion. Stimulation of PBM by SEA resulted in increased levels of IL-1beta, IL-2 and interferon (IFN)-gamma after 24h. Further stimulation for 72-120h resulted in a significant increase in the levels of IL-1beta, IFN-gamma and tumour necrosis factor (TNF). Stimulation of PBM with SEA also resulted in increased levels of soluble and L-selectin in the cell supernatants. Increased cell-surface expression of E-selectin, ICAM-1, HLA-DR and VCAM-1 was detected on HUVEC stimulated with CM-SEA media. While E-selectin and VCAM were induced on HUVEC within a few hours, induction of ICAM and HLA-DR required a longer induction period. Adhesion of HL-60 cells to HUVEC treated with CM-SEA was inhibited by monoclonal antibodies (MoAbs) against both the selectin and integrin families of cell adhesion molecules, suggesting that multiple pathways contribute to SEA-induced leucocyte extravasation. The results suggested that selectin-dependent adhesion was more prominent during the early phase while integrin-induced adhesion occurred at a later stage.
ChemInform Abstract: A Short Synthesis of the Erythrina Skeleton and of (.+‐.)‐α‐Lycorane. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture (2011)

The integrin αvβ8 is a cell surface receptor for the latent domain (LAP) of the multifunctional cytokine TGF-β. Through its association with LAP, TGF-β is maintained in a latent form that must be activated to function. Binding to the integrin αvβ8 with subsequent metalloproteolytic cleavage of LAP represents a major mechanism of TGF-β activation in vivo. Altered expression of the integrin β8 subunit (ITGB8) is found in human chronic obstructive pulmonary disease, cancers, and brain vascular malformations. We have previously shown that the proinflammatory cytokine interleukin-1β (IL-1β) increases ITGB8 expression on lung fibroblasts, which increases αvβ8-mediated TGF-β activation in fibrosis and pathologic inflammation. Here we report the mechanism of increased ITGB8 expression by IL-1β. Our data support a model where the chromatin architecture of the ITGB8 core promoter is altered by nucleosomal repositioning that enhances the interaction of an AP1 complex (containing c-Jun and ATF2). This repositioning is caused by the dissociation of HDAC2 with the ITGB8 core promoter, leading to increased histone H4 acetylation and a loosening of nucleosomal-DNA interactions allowing "opening" of the chromatin structure and increased association of c-Jun and ATF-2. These changes are mediated through NFκB- and p38-dependent pathways. Ultimately, these events culminate in increasing ITGB8 transcription, αvβ8 surface expression, and αvβ8-mediated TGFβ activation.
Smartphone-Based Blood Pressure Monitoring via the Oscillometric Finger Pressing Method: Analysis of Oscillation Width Variations Can Improve Diastolic Pressure Computation (2023)

The study findings may help in converting widely available devices into truly cuffless BP monitors for improving hypertension awareness and control.
Time optimal and loss minimizing deadbeat-direct torque and flux control for interior permanent magnet synchronous machines (2012)

This paper presents time optimal control of an interior permanent magnet synchronous machine (IPMSM) in voltage- and current- limited conditions using deadbeat-direct torque and flux control (DB-DTFC). A commanded air-gap torque and flux can be achieved by the end of each PWM period using DB-DTFC. However, it may take several PWM periods to achieve a desired torque that is physically infeasible in one step when operating near the voltage limit. The large torque command can be shaped as a feasible trajectory so that the deadbeat torque and flux is achieved for every sample time instant (switching period) along the trajectory. In this paper, the feasible trajectory is dynamically optimized to achieve a large torque command in the shortest time during voltage- and current-limited operation. Loss minimizing stator flux linkage is used during steady state operation to reduce computational complexity of the dynamic optimization and to operate the IPMSM at the loss minimizing condition. The voltage- and current-limited operation of IPMSM drives is evaluated in both simulation and experiment in this paper.
Theoretical predictions of harmonic generation from submicron ultrasound contrast agents for nonlinear biomedical ultrasound imaging (2006)

Submicron ultrasound contrast agents have aroused attention for their significant promise in ultrasonic contrast/molecular imaging, targeted therapy and echo particle imaging velocimetry. However, nonlinear acoustic properties of submicron encapsulated gas bubbles for ultrasonic applications are still not clearly understood. In this paper, nonlinear acoustic emission characteristics from submicron bubbles were examined using a numerical study. The modified RP equation incorporating viscosity, acoustic radiation, thermal effects and encapsulated shell was used to study single bubble dynamics. Further, a size integration method, shown previously to be useful in prediction of backscatter spectra from groups of bubbles, was applied to analyse response from a bubble population. We show that bubbles with radii (200-500 nm) produce significant subharmonic and ultraharmonic components of the backscatter spectrum, while smaller bubbles (<200 nm) provide substantial second harmonic components. Additionally, nanoscale bubbles (<100 nm) produce very low backscatter amplitudes and thus may not be useful with the use of current ultrasound technology. Analysing optimal ultrasound driving pressures and bubbles size ranges for maximal subharmonic and ultraharmonic signals showed that sub and ultraharmonic mode nonlinear imaging methods may be potentially competitive for larger size bubbles (>200 nm) in providing proper contrast-to-tissue signal ratios.
ChemInform Abstract: A Combined Intramolecular—Intermolecular One‐Pot Glycosylation Approach for the Synthesis of a Branched Trisaccharide. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 7. 7‐Amino‐4‐(phenylamino)‐ and 7‐ Amino‐4‐((phenylmethyl)amino)pyrido(4,3‐d)pyrimidines: A New Class of Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Computer Simulation Of Electrostatic Well Formation In Spherical Inertial Electrostatic Plasma (SIEC) confinement (1991)

The Inertial Electrostatic Confinement (IEC) concept involves trapping of charged particles in potential wells of electric fields which are produced by ions and electrons injected radially inwards into a grided (anode-cathode) spherical configuration. Simulations of the IEC concept for confinement have been done using the XL code. Written as an aid in the design and analysis of experimental devices (such as the U of I experiment and the magnetic spherical confinement experiment at DTI <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> ) is a electrostatic Poisson solver design specifically for spherical geometry. Its primary purpose is to solve for an electrostatic potential consistent with charged particle dynamics, and various versions can be run on a PC or workstation. Modeling of the Illinois IEC experiment shows that a virtual anode is formed in the simulation at 100-mA ion current and 10-kV cathode voltage. Results for a range of parameters (voltages, grid transparancies, background pressures, injected currents) will be presented along with select comparisons to results from the Illinois experiment.
Selective Growth of CdTe on Patterned CdS Substrates for High Efficiency CdTe Solar Cells. (2012)

Abstract not provided.
Solid-State Analysis of Low-Melting 1,3-Dialkylimidazolium Hexafluorophosphate Salts (Ionic Liquids) by Combined X-ray Crystallographic and Computational Analyses (2007)

The interactions of ions in the solid state for a series of representative 1,3-dialkylimidazolium hexafluorophosphate salts (either ionic liquids or closely related) have been examined by crystallographic analysis, combined with the theoretical estimation of crystal-packing densities and lattice-interaction energies. Efficient close-packing of the ions in the crystalline states is observed, but there was no compelling evidence for specific directional hydrogen-bonding to the hexafluorophosphate anions or the formation of interstitial voids. The close-packing efficiency is supported by the theoretical calculation of ion volumes, crystal lattice energies, and packing densities, which correlated well with experimental data. The crystal density of the salts can be predicted accurately from the summation of free ion volumes and lattice energies calculated. Of even more importance for future work, on these and related salts, the solid-state density of 1,3-dialkylimidazolium hexafluorophosphate salts can be predicted with reasonable accuracy purely on the basis of on ab initio free ion volumes, and this allows prediction of lattice energies without necessarily requiring the crystal structures.
The Indirect Role of Executive Functions on the Relationship between Cardiorespiratory Fitness and School Grades (2021)

These results show the role that executive functions play in understanding the relationship between cardiorespiratory fitness and scholastic performance. Importantly, not all executive function domains contributed equally because cognitive flexibility played a leading role in this wide age range. Furthermore, the relationship between cardiorespiratory fitness and scholastic performance was strongest for mathematics and for low-level language topics but nonsignificant for higher-level language topics, providing a more modulated view of the effect of cardiorespiratory fitness on language.
Workload decomposition for QoS in hosted storage services (2008)

The growing popularity of hosted storage services and shared storage infrastructure in data centers is driving the recent interest in performance isolation and QoS in storage systems. Due to the bursty nature of storage workloads, meeting the traditional response-time Service Level Agreements requires significant over provisioning of the server capacity. We present a graduated, distribution-based QoS specification for storage servers that provides cost benefits over traditional QoS models. Our method RTT partitions the workload to minimize the capacity required to meet response time requirements of any specified fraction of the requests.
Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening (2015)

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons of the substantia nigra. The hallmark of PD is the appearance of neuronal protein aggregations known as Lewy bodies and Lewy neurites, of which α-synuclein forms a major component. Familial PD is rare and is associated with missense mutations of the SNCA gene or increases in gene copy number resulting in SNCA overexpression. This suggests that lowering SNCA expression could be therapeutic for PD. Supporting this hypothesis, SNCA reduction was neuroprotective in cell line and rodent PD models. We developed novel cell lines expressing SNCA fused to the reporter genes luciferase (luc) or GFP with the objective to enable high-throughput compound screening (HTS) for small molecules that can lower SNCA expression. Because SNCA expression is likely regulated by far-upstream elements (including the NACP-REP1 located at 8852 bp upstream of the transcription site), we employed zinc finger nuclease (ZFN) genome editing to insert reporter genes in-frame downstream of the SNCA gene in order to retain native SNCA expression control. This ensured full retention of known and unknown up- and downstream genetic elements controlling SNCA expression. Treatment of cells with the histone deacetylase inhibitor valproic acid (VPA) resulted in significantly increased SNCA-luc and SNCA-GFP expression supporting the use of our cell lines for identifying small molecules altering complex modes of expression control. Cells expressing SNCA-luc treated with a luciferase inhibitor or SNCA siRNA resulted in Z'-scores ≥ 0.75, suggesting the suitability of these cell lines for use in HTS. This study presents a novel use of genome editing for the creation of cell lines expressing α-synuclein fusion constructs entirely under native expression control. These cell lines are well suited for HTS for compounds that lower SNCA expression directly or by acting at long-range sites to the SNCA promoter and 5'-UTR.
Um ambiente de aprendizagem informal com recomendações de conteúdos para portadores de doenças crônicas (2019)

Doenças crônicas impõem diversas limitações às condições de saúde do seu portador. Estas doenças, nos últimos 10 anos, cresceram mais de 60%, tornando assim necessário um software que possa atender tanto a demanda do paciente, quanto a demanda do especialista em saúde. Dessa forma, aprender mais sobre a doença ajuda a melhorar a qualidade de vida. Web 2.0, ao longo dos anos, se tornou uma grande aliada na busca de conhecimento, possibilitando que o paciente se torne mais ativo no tratamento da sua doença. Todavia, a procura por informações que se adequem ao contexto do paciente pode ser difícil, devido ao grande volume de informações disponíveis. Este trabalho apresenta um ambiente que busca amenizar essa dificuldade, analisando o perfil do usuário, seus dados de saúde e suas relações com pessoas com o mesmo problema de saúde e assim proporcionando uma recomendação mais adequada às suas necessidades. Parte desse ambiente é constituído por um Módulo de Intermediário do Especialista que possibilita o acesso a um conjunto de informações do tratamento de pacientes, buscando tornar o tratamento dos pacientes mais adequado.
Solid rocket motor fire tests: Phases 1 and 2 (2002)

JHU/APL conducted a series of open-air burns of small blocks (3 to 10 kg) of solid rocket motor (SRM) propellant at the Thiokol Elkton MD facility to elucidate the thermal environment under burning propellant. The propellant was TP-H-3340A for the STAR 48 motor, with a weight ratio of 71/18/11 for the ammonium perchlorate, aluminum, and HTPB binder. Combustion inhibitor applied on the blocks allowed burning on the bottom and/or sides only. Burns were conducted on sand and concrete to simulate near-launch pad surfaces, and on graphite to simulate a low-recession surface. Unique test fixturing allowed propellant self-levitation while constraining lateral motion. Optics instrumentation consisted of a longwave infrared imaging pyrometer, a midwave spectroradiometer, and a UV/visible spectroradiometer. In-situ instrumentation consisted of rod calorimeters, Gardon gauges, elevated thermocouples, flush thermocouples, a two-color pyrometer, and Knudsen cells. Witness materials consisted of yttria, ceria, alumina, tungsten, iridium, and platinum/rhodium. Objectives of the tests were to determine propellant burn characteristics such as burn rate and self-levitation, to determine heat fluxes and temperatures, and to carry out materials analyses. A summary of qualitative results: alumina coated almost all surfaces, the concrete spalled, sand moisture content matters, the propellant self-levitated, the test fixtures worked as designed, and bottom-burning propellant does not self-extinguish. A summary of quantitative results: burn rate averaged 1.15 mm/s, thermocouples peaked at 2070 C, pyrometer readings matched MWIR data at about 2400 C, the volume-averaged plume temperatures were 2300–2400 C with peaks of 2400–2600 C, and the heat fluxes peaked at 125 W/cm2. These results are higher than other researchers’ measurements of top-burning propellant in chimneys, and will be used, along with Phase 3 test results, to analyze hardware response to these environments, including General Purpose Heat Sources (GPHS) and Radioisotope Heater Units (RHU). Follow-on Phase 3 tests burning propellant blocks up to 90 kg will be briefly described.