gebhart/patrepeval huggingface dataset:
Data from The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T cells (CART-BCMA) are a promising treatment for relapsed/refractory multiple myeloma (r/rMM). We evaluated the safety and feasibility of bridging radiation (RT) in subjects treated on a phase I trial of CART-BCMA.&lt;/p&gt;Experimental Design:&lt;p&gt;Twenty-five r/rMM subjects were treated in three cohorts with two doses of CART-BCMA cells ± cyclophosphamide. We retrospectively analyzed toxicity, response, and CART manufacturing data based on RT receipt.&lt;/p&gt;Results:&lt;p&gt;Thirteen subjects received no RT &lt;1 year before CART infusion (Group A). Eight subjects received RT &lt;1 year before CART infusion (Group B) with median time from RT to apheresis of 114 days (range 40–301). Four subjects received bridging-RT (Group C) with a median dose of 22 Gy and time from RT to infusion of 25 days (range &lt;a href="#bib18 bib19 bib20 bib21 bib22 bib23 bib24 bib25 bib26 bib27 bib28 bib29 bib30 bib31 bib32 bib33 bib34 bib35" target="_blank"&gt;18–35&lt;/a&gt;). Group C had qualitatively lower rates of grade 4 (G4) hematologic toxicities (25%) versus A (61.5%) and B (62.5%). G3–4 neurotoxicity occurred in 7.7%, 25%, and 25% in Group A, B, and C, respectively. G3–4 cytokine release syndrome was observed in 38.5%, 25%, and 25% in Group A, B, and C, respectively. Partial response or better was observed in 54%, 38%, and 50% of Group A, B, and C, respectively. RT administered &lt;1 year (&lt;i&gt;P&lt;/i&gt; = 0.002) and &lt;100 days (&lt;i&gt;P&lt;/i&gt; = 0.069) before apheresis was associated with lower &lt;i&gt;in vitro&lt;/i&gt; proliferation during manufacturing; however, &lt;i&gt;in vivo&lt;/i&gt; CART-BCMA expansion appeared similar across groups.&lt;/p&gt;Conclusions:&lt;p&gt;Bridging-RT appeared safe and feasible with CART-BCMA therapy in our r/rMM patients, though larger future studies are needed to draw definitive conclusions.&lt;/p&gt;&lt;/div&gt;
Supplementary Table 2 from Common Structural and Epigenetic Changes in the Genome of Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;XLS file - 15K, Genes with copy number aberrations in _&gt;66% of samples (N=15).&lt;/p&gt;
Ultra-Low Noise, Sub-100 MHz Pulse Train Based On a Temporally Demultiplexed Mode-Locked Laser (2009)

A semiconductor low-noise, sub-100MHz repetition rate laser source is developed by time demultiplexing a harmonically mode-locked 2.56GHz, SCOWA-based mode-locked laser to the cavity fundamental frequency. The laser source is suitable for time-stretched photonic ADC.
Protocols for PLC Systems (2010)

Networks and protocols reside above the physical layer of Power Line Communications (PLC) systems and may interface between the PLC system and a mix of users, services and applications. This chapter considers protocol design for three different application scenarios using PLC. It discusses media access schemes and resource sharing strategies for broadband PLC systems. PLC networks are considered as infrastructures for energy management systems. In this application scenario, the emphasis for protocol design is on availability and reliability of communication services. The chapter presents the problem of high-quality video distribution in end-to-end Internet Protocol Television (IPTV) services over PLC as an in-house broadband communication network. The challenge for IPTV over PLC lies in the fact that impulse noise, a common disturbance in PLC channels, causes long error bursts which cannot be corrected by physical layer forward error correction coding. Controlled Vocabulary Terms carrier transmission on power lines; forward error correction; Internet protocol television; IP networks
Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison (2019)

These results advance our understanding of the global plasma proteomic response to EBOV and <i>Bp</i> infection in relevant primate models for human disease and provide insight into potential innate immune response differences between viral and bacterial infections.
Organic Radical Battery (2005)

Organic Molecular Radicals—An organic molecular radical is a molecular entity possessing one unpaired electron such as ·CH 3 and ·CCl 3 , in which the dot symbolizes an unpaired electron.
Magnetization-dependent loss in an (Al,Ga)As optical waveguide with an embedded Fe micromagnet (2010)

The dependence of waveguiding loss on the magnetization of a Fe micromagnet embedded into the (Al,Ga)As optical waveguide was examined as a possible readout method for the spin-photon memory. The optical detection of the magnetization direction of a Fe micromagnet was demonstrated for the micromagnet sizes of 3 microm x 4 microm and 3 microm x 8 microm with signal-to-noise ratios of 4.8 and 6 dB, respectively. In the case of smaller sizes, the use of spin injection from the micromagnet into a semiconductor optical amplifier was proposed for the optical detection of the magnetization.
Gas-phase C-F bond cleavage in perfluorohexane using W-, Si-, P-, Br-, and I-containing ions: Comparisons with reactions at fluorocarbon surfaces (1998)

Gas-phase reactions of W-, Si-, P-, Br-, and I-containing ions with the target molecule perfluorohexane at low collision energies (<15 eV) parallel known ion/surface reactions of the same projectile ions at fluorinated self-assembled monolayer surfaces. Charge exchange, dissociative charge exchange, and fluorine atom abstraction are observed and the majority of the projectile ions also undergo reactive charge exchange to produce specific fluorocarbon fragment ions of the target molecule in distinctive relative abundances. Abstraction of up to five fluorine atoms is observed upon collision of W+ with gaseous perfluorohexane, while similar experiments with CI+, SiCl+, and PCl+· show abstraction of one or two fluorine atoms. Other projectiles, including Si+·, PCl2+, Br+, CBr+, and I+, abstract only a single fluorine atom. These patterns of fluorine atom abstraction are similar to those observed in ion/surface collisions. Also paralleling the ion/surface reactions, halogen exchange (Cl-for-F) reactions occur between the Cl-containing projectile ions and perfluorohexane to produce C6F12Cl+, a product of chemical modification of the target. Collisions of PCl+· and PCl2+ also result in production of C6F12+·, indicating that the corresponding surface modification reaction involving molecular defluorination should be sought. Implications for previously proposed mechanisms, new ion/surface reactions, and for the use of gas-phase studies to guide investigations of the ion/surface reactions are discussed.
Homogeneous and evanescent contributions in scalar near-field diffraction (1995)

The contributions of homogeneous and evanescent waves to two-dimensional near-field diffraction patterns of scalar optical fields are examined in detail. The total plane-integrated intensities of the two contributions are introduced as convenient measures of their relative importance. As an example, the diffraction of a plane wave by a slit is considered.
The Bimode Cross Switch (BXS) a full hybrid solution in switch- and diode-modes (2016)

In this paper, we present for the first time, the experimental results of a “Bimode Cross Switch (BXS)-Hybrid” built with 3.3kV Silicon Enhanced Trench Bi-mode IGBTs (Si-ET-BIGT) and Silicon Carbide MOSFETs (SiC-MOSFET). Also, we have compared the static (on-state) and dynamic (switching) characteristics of the 3.3kV BXS-Hybrid (1 × Si-ET-BIGT + 2 × SiC-MOSFET) with the full SiC-MOSFET (4 × SiC-MOSFET) and full Si-ET-BIGT (2 × Si-ET-BIGT) reference samples. In addition, we have investigated the MOS gate control (blanking time tbl) influence in diode-mode during reverse recovery of the BXS-Hybrid and compared the results to those of the full Si-ET-BIGT. The experimental results show that BXS-Hybrid offers 45% and 75% reduction in the turn-off losses (in switch-mode) compared to full Si-ET-BIGT at nominal current (125A) and half-nominal current, respectively for nearly the same on-state voltage drop (at nominal current) or even much lower (at half nominal current). Also, the results show that the BXS-Hybrid offers 46% and 49% reduction in the reverse recovery losses (in diode-mode) compared to full Si-ET-BIGT at nominal current and half-nominal current, respectively. Furthermore, the results show that the reverse recovery losses can be reduced as much as 55% with the BXS-Hybrid compared to that of the full Si-ET-BIGT if the MOS gate control technique is used (for the tbl of 2μs). In addition, the BXS-Hybrid eliminates or reduces the oscillations compared to full SiC-MOSFET solution. In this study, the MOS gates of the devices in the BXS-Hybrid were connected together and controlled by the same single gate unit (with one common gate resistor).
Design and properties of low-energy X-ray transmission windows based on graphenic carbon (2015)

X-ray transmission windows for the low energy range, especially between 0.1 and 1 keV have been designed and fabricated based on graphenic carbon (GC) with an integrated silicon frame. A hexagonal and a bar grid support structure design have been evaluated. The bar grid design offers higher X-ray transmission and better visible light rejection than polymer-based windows, and allows vacuum encapsulation of silicon drift detectors (SDD). The high mechanical resilience of graphenic carbon is demonstrated by pressure cycle tests, yielding over 10 million cycles without damage. The data are complemented by bulge tests to determine a Young's modulus for graphenic carbon of approximately 130 GPa. Additional finite-element simulation and Raman studies reveal that the mechanical stress is not homogeneously distributed, but reaches a maximum near the anchoring points of the free standing graphenic carbon membrane. The cross-section of a vacuum encapsulated silicon drift detector (SDD) in (a) shows the highly transparent X-ray transmission window that is integrated into the top of a TO8 housing. The photograph (b) shows a prototype TO8 detector module with a graphenic carbon low-energy transmission window with an hexagonal support grid structure.
Analysis of multiple-quantum-well distributed feedback laser (1986)

The doping and detuning dependences of the threshold, dynamic and spectral properties of multiple-quantum-well distributed feedback lasers were analysed theoretically. It was shown that optimised detuning improves the dynamic and spectral properties. It was also shown that donor doping significantly reduces the threshold current and spectral line-width.
Small wideband antennas based on Photonic Crystals (2010)

In this paper we propose an approach for designing wideband metamaterial antennas. Our design is based on the wave-slow down provided by coupled-TL (Transmission Line) sections that emulate anisotropic volumetric media (Photonic Crystals). These sections are used to couple antenna elements arranged in an array, thus leading to very large bandwidths (10:1) even when the array is conformally installed on a ground plane.
Coordinated Control of Wind Turbine Generator and Energy Storage System for Frequency Regulation under Temporal Logic Specifications (2018)

In this paper, we present a coordinated control method for wind turbine generator and energy storage system for frequency regulation with provable probabilistic guarantees in the stochastic environment of wind power generation. The regulation requirement is specified in the form of metric temporal logic (MTL). We present the stochastic control bisimulation function, which bounds the divergence of the trajectories of the stochastic control system and the diffusionless deterministic control system in a probabilistic fashion. We first design a feedforward controller by solving an optimization problem for the nominal trajectory of the deterministic control system with robustness against initial state variations and stochastic uncertainties. Then we generate a feedback control law from the data of the simulated trajectories. We implement our control method on a four-bus system and test the effectiveness of the method with a generation loss disturbance. We also test the advantage of the feedback controller over the feedforward controller when unexpected disturbance occurs.
Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis. (1996)

Immunohistochemical and confocal microscopic studies of the localization of matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and type IV collagen were made in lung tissues from patients with normal pulmonary histology (n = 3), diffuse alveolar damage (n = 14), and idiopathic pulmonary fibrosis (n = 12). Pretreatment with pepsin revealed otherwise undetectable MMP- and TIMP-immunoreactive sites. In normal lung, MMP-2, MMP-9, TIMP-1, and TIMP-2 were localized in ciliated cells, endothelial cells, pneumocytes, macrophages, and smooth muscle cells; fibroblasts showed a strong reaction only for MMP-2. Only TIMP-2 showed co-localization with type IV collagen. Myofibroblasts and epithelial cells expressed increased reactivity for MMPs and TIMPs in both disorders. The reactivities for MMPs and TIMPs were stronger in diffuse alveolar damage. MMP-2 showed focal co-localization in capillary endothelial and disrupted epithelial basement membranes, suggesting activation of collagenolysis. A protective effect against this lysis was suggested by the extensive co-localization of TIMP-2 with type IV collagen and fibrillar collagens. Alveolar buds showed increased reactivity for MMPs and TIMPs in their lining epithelial cells, myofibroblasts, and their basement membranes; however, their matrices were mostly unreactive. These findings emphasize the complexity of the roles of MMPs and TIMPs in collagen turnover in diffuse alvcolar damage and idiopathic pulmonary fibrosis.
Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model (2021)

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known and can induce respiratory failure requiring long-term intensive care. Treatment of botulism includes the administration of antitoxins. Monoclonal antibodies (mAbs) hold considerable promise as BoNT therapeutics and prophylactics, due to their potency and safety. A three-mAb combination has been developed that specifically neutralizes BoNT serotype A (BoNT/A), and a separate three mAb combination has been developed that specifically neutralizes BoNT serotype B (BoNT/B). A six mAb cocktail, designated G03-52-01, has been developed that combines the anti-BoNT/A and anti-BoNT/B mAbs. The pharmacokinetics and neutralizing antibody concentration (NAC) of G03-52-01 has been determined in guinea pigs, and these parameters were correlated with protection against an inhalation challenge of BoNT/A1 or BoNT/B1. Previously, it was shown that each antibody demonstrated a dose-dependent mAb serum concentration and reached maximum circulating concentrations within 48 h after intramuscular (IM) or intraperitoneal (IP) injection and that a single IM injection of G03-52-01 administered 48 h pre-exposure protected guinea pigs against an inhalation challenge of up to 93 LD<sub>50</sub>s of BoNT/A1 and 116 LD<sub>50</sub>s of BoNT/B1. The data presented here advance our understanding of the relationship of the neutralizing NAC to the measured circulating antibody concentration and provide additional support that a single IM or intravenous (IV) administration of G03-52-01 will provide pre-exposure prophylaxis against botulism from an aerosol exposure of BoNT/A and BoNT/B.
A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile (2004)

Das vollständige Kohlenstoffgerüst von Welwitindolinon-A-isonitril wurde durch eine [2+2]-Cycloaddition (Aufbau des Bicyclo[4.2.0]octan-Kerns) und eine SmI2-vermittelte intramolekulare reduktive Cyclisierung zwischen einem Enon und einem Arylisocyanat (stereoselektive Bildung der Spirooxindol-Gruppe) erhalten (siehe Schema; DBU=1,8-Diazabicyclo[5.4.0]undec-7-en). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z53282_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Supplementary figures 1 through 15 and Supplementary Tables 1 through 5 from Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor (2023)

&lt;p&gt;Gating strategy, Shannon entropy, PD-1 expression, additional co-culture data, primers sequence, Frequency of the top 10 CD8+PD-1+ TCRB in bulk unsorted TIL and sorted TIL subsets, Retrospective analysis of pairing the most frequent TCRB in the CD8+PD-1+ TIL subset with the most frequent TCRA from the same subset, Method of identification of TCR pairs, TCR expression on genetically engineered PBL.&lt;/p&gt;
Cleavage stage porcine embryos may have differing developmental requirements for karyopherins α2 and α3 (2003)

Numerous cellular proteins are able to localize to the nucleus due to the fact that they possess a nuclear localization signal (NLS) in their amino acid sequence. Nuclear localization sequences recognized by the importin alpha/beta heterodimer are found in cellular proteins capable of performing many diverse functions, ranging from chromatin remodeling to cell cycle regulation. Evidence has been presented that suggests individual importin alpha homologues are present at varying levels in different adult tissues. Other data have shown that specific subsets of NLSs found in different cellular proteins are recognized by individual importin alpha homologues with varying affinities. This evidence led us to hypothesize that due to the specific cargoes they carry, the mammalian embryo has different developmental requirements for individual importin alpha homologues. The results of the studies presented here indicate that importin alpha/beta-mediated import occurs throughout early cleavage in the porcine embryo, as determined by a reporter protein microinjection assay, and that multiple importin alpha homologues are present throughout early cleavage, as determined by immunocytochemical analysis. An RNA interference approach was used in an attempt to determine the developmental requirements for specific importin alpha homologues during early cleavage in the porcine embryo. Results from this study showed that fertilized porcine embryos injected with double stranded RNA (dsRNA) corresponding to the importin alpha homologue karyopherin alpha3 had significantly fewer nuclei following four days of culture than did embryos injected with dsRNA for another importin alpha homologue, karyopherin alpha2, or two control groups. This is the first report indicating that mammalian embryos may have differential developmental requirements for specific nuclear trafficking pathways.
A neural network model of optical gyros drift errors with application to vehicular navigation (2004)

Inertial navigation systems (INS) incorporating three mutually orthogonal accelerometers and three mutually orthogonal gyroscopes are integrated with global positioning systems (GPS) to provide reliable and accurate positioning information for vehicular navigation. Because of their high reliability and accuracy, ring laser gyroscopes (RLG) and fiber optic gyroscopes (FOG) are usually utilized inside most of the present INS. However, bias drift at the output of these optical gyroscopes may deteriorate the performance of the overall INS/GPS navigation system. This paper introduces a method to enhance the performance of optical gyros in two phases. The first phase utilizes wavelet multi-resolution analysis to band limit the gyro measurement and improves its signal-to-noise ratio. The second phase employs radial-basis function (RBF) neural networks to predict drift errors. The drift model provided by the RBF network is established using the gyro raw measurement and time as inputs and provides the drift error at its output. The RBF neural networks are utilized in this study since they generally have simpler architecture and faster training procedure than other neural network types. The proposed method is applied to E-core 2000 FOG (KVH Industries Inc., Rhode Island, USA).
MECHANISMS OF LYMPHOCYTE-MEDIATED CYTOTOXICITY IN ACUTE RENAL ALLOGRAFT REJECTION1 (1998)

The perforin/GrB-based pathway is mainly responsible for cytotoxicity of GIC lines toward corresponding donor PTEC lines, suggesting that this pathway predominates in tubular epithelial cell destruction by cytotoxic T lymphocytes during acute renal allograft rejection in vivo.
Factors Affecting Floc Properties During Aerobic Digestion: Implications for Dewatering (1999)

Laboratory aerobic digestion studies were conducted to determine the effect of divalent cations on the characteristics of aerobically digested activated sludge. Separate reactors were operated at two divalent cation concentrations. Characteristics examined included dewatering properties (cake solids, specific resistance to filtration, and capillary suction time), polymer conditioning requirement, floc strength, supernatant chemical oxygen demand (COD), supernatant turbidity, soluble cations (sodium, potassium, calcium, magnesium, and ammonium ions), soluble anions (nitrate and nitrite), and soluble exocellular polymers (proteins and polysaccharides). The reactor containing higher amounts of calcium and magnesium (1.25 mM each) exhibited better dewatering properties, higher floc strength, lower polymer conditioning requirement, lower soluble COD, lower supernatant turbidity, and lower soluble exocellular polymers than the reactor containing lower calcium and magnesium concentrations (0.40 mM each). Floc deterioration was associated with a release of soluble proteins and polysaccharides and monovalent cations (sodium and potassium) to the bulk solution. Divalent cations were not released to the bulk solution, indicating they may participate in floc binding. Mineralization of nitrogen was not affected, suggesting that aerobic digestion of activated‐sludge solids (degradation rates) was not affected. These results imply that the addition of divalent cations improves aerobic digester performance with regard to floc properties, supernatant quality (implications for recycled COD), and dewatering performance.
Topological Nature of Optical Bound States in the Continuum (2014)

Optical bound states in the continuum (BICs) have recently been realized in photonic crystal slabs, where the disappearance of out-of-plane radiation turns leaky resonances into guided modes with infinite lifetimes. We show that such BICs are vortex centers in the polarization directions of far-field radiation. They carry conserved and quantized topological charges, defined by the winding number of the polarization vectors, which ensure their robust existence and govern their generation, evolution, and annihilation. Our findings connect robust BICs in photonics to a wide range of topological physical phenomena.
Supplementary Figure 2 from <i>De novo</i> Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation (2023)

Supplementary Figure 2 from &lt;i&gt;De novo&lt;/i&gt; Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation