gebhart/patrepeval huggingface dataset:
Multichannel analyzer/detector system for high-speed high-resolution powder diffraction (1998)

The advantage of using high-resolution powder diffraction data to resolve ambiguities in powder diffraction analyses is widely understood. The problem with using such an instrument for routine analyses is the length of time needed to acquire a data set. An obvious solution is to introduce some parallelism in the detector/analyzer system. The system described here uses monolithic elastic design principles to construct a simple 16-element crystal analyzer, and it uses silicon multi-detector technology developed at Brookhaven to provide a compact 16-channel pulse-counting detector system. Together these components can decrease the data collection time by at least a factor of 10. Simple replication of components could further increase the efficiency of collection.
Laser-fabricated low-loss single-mode raised-rib waveguiding devices in polymers (1996)

Organic polymeric materials offer a versatile medium for the creation of low-cost large-area optical guided-wave structures. In this work, we report on the use of a novel maskless laser-based microfabrication technique for the photochemical delineation of raised-rib single-mode waveguiding devices in polymers. This technology relies on accurate control of small refractive index differences (which is achieved by using intermiscible acrylate monomers), use of high-contrast photochemical response, as well as precise control of laser writing parameters. The devices reported here have cross-sectional dimensions and numerical apertures that match single-mode glass optical fibers. They exhibit very low losses of 0.03 dB/cm at 840 nm and exceptional thermal stability. We present the operational characteristics of bends, Y-branches, and directional couplers fabricated using this technology and compare these characteristics with those predicted from theory.
Kneallhazia(=Thelohania)SolenopsaeInfection Rate ofPseudacteon curvatusFlies Determined by Multiplex PCR (2009)

A multiplex PCR method was developed and used to determine the infection rate of Kneallhazia solenopsae in individual Pseudacteon curvatus flies in north-central Florida. Among P. curvatus flies infected with K. solenopsae, 2 amplicons were produced, one of 800 nucleotides from the P. curvatus 18S rRNA gene, and one of 318 nucleotides from the K. solenopsae 16S rRNA gene. Multiplex PCR of DNA extracted from P. curvatus flies was capable of detecting 117.5 ± 82.7 K. solenopsae spore equivalents. The mean K. solenopsae infection rate of P. curvatus from 4 sites in Gainesville and Williston, Florida, was 12.3 ± 5.0%. The K. solenopsae infection rate for P. curvatus was independent of the K. solenopsae infection rate observed among S. invicta nests from where the fly collections took place. Not all P. curvatus flies that developed in K. solenopsae-infected fire ants were positive for K. solenopsae upon eclosion. Among 50 P. curvatus flies known to develop in K. solenopsae-infected S. invicta workers, 12 (24%) were positive for K. solenopsae at eclosion.
Compressible turbulent channel flow with impedance boundary conditions (2014)

We have performed large-eddy simulations of isothermal-wall compressible turbulent channel flow with linear acoustic impedance boundary conditions (IBCs) for the wall-normal velocity component and no-slip conditions for the tangential velocity components. Three bulk Mach numbers, Mb = 0.05, 0.2, 0.5, with a fixed bulk Reynolds number, Reb = 6900, have been investigated. For each Mb, nine different combinations of IBC settings were tested, in addition to a reference case with impermeable walls, resulting in a total of 30 simulations. The adopted numerical coupling strategy allows for a spatially and temporally consistent imposition of physically realizable IBCs in a fully explicit compressible Navier-Stokes solver. The IBCs are formulated in the time domain according to Fung and Ju [“Time-domain impedance boundary conditions for computational acoustics and aeroacoustics,” Int. J. Comput. Fluid Dyn. 18(6), 503–511 (2004)]. The impedance adopted is a three-parameter damped Helmholtz oscillator with resonant ...
Symbol-rate timing error detectors for DSL transceivers (2004)

Symbol-rate timing error detectors are derived which allow to optimize the synchronization of single carrier DSL transceivers. The synchronizer input signal in DSL receivers does not have the ideal characteristics which are assumed by many synchronizer algorithms in the literature. Impairments and distortion of the DSL channel require a decision feedback equalizer in the receiver. A timing error detector in the control loop has optimal performance, if the jitter is minimal. Therefore timing jitter due to additive noise and due to synchronizer self-noise generally described and analyzed as a function of the synchronizer implementation, channel characteristics and noise scenario. New timing error detector implementations are systematically derived which have better synchronizer performance than timing error detectors known from the literature.
Perimetric Threshold Variability and Age (1988)

<h3>To the Editor.</h3> —We read with interest the recent article by Katz and Sommer<sup>1</sup>on age-adjusted variability of automated visual fields. The authors analyzed the variability of threshold-measuring computerized perimetry in 26 eyes from a nonrandom normal population, with each eye tested three times over a period of 18 months. They concluded that the variation was highly dependent on the age of the individual, being larger in older subjects. We have recently reported a prospective analysis of intratest, intertest, and interindividual variability of randomly selected normal individuals<sup>2</sup>using the same instrument and test program as that used by Katz and Sommer. We did not report the effect of age on intertest variability in any detail, and since our results do not entirely agree with those of Katz and Sommer, we present them here. <h3>Subjects and Methods.</h3> —Our analyses were performed on one eye from each of
Structure of the light emitter in krill (Euphausia pacifica) bioluminescence (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of the light emitter in krill (Euphausia pacifica) bioluminescenceHideshi. Nakamura, Branislav. Musicki, Yoshito. Kishi, and Osamu. ShimomuraCite this: J. Am. Chem. Soc. 1988, 110, 8, 2683–2685Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ja00216a070https://doi.org/10.1021/ja00216a070research-articleACS PublicationsRequest reuse permissionsArticle Views349Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A design for implementation of the Internet protocol in a local ATM network (2002)

This paper deals with design and implementation issues of the Internet protocol (IP) on a local ATM (LATM) network configured as an IP subnetwork. More specifically, we address the problem of address resolution and propose a server based approach. We discuss in detail the internal architecture of the servers and other related issues.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Amino Acid Substitutions Improve the Immunogenicity of H7N7HA Protein and Protect Mice against Lethal H7N7 Viral Challenge (2015)

Avian influenza A H7N7/NL/219/03 virus creates a serious pandemic threat to human health because it can transmit directly from domestic poultry to humans and from human to human. Our previous vaccine study reported that mice when immunized intranasally (i.n) with live Bac-HA were protected from lethal H7N7/NL/219/03 challenge, whereas incomplete protection was obtained when administered subcutaneously (s.c) due to the fact that H7N7 is a poor inducer of neutralizing antibodies. Interestingly, our recent vaccine studies reported that mice when vaccinated subcutaneously with Bac-HA (H7N9) was protected against both H7N9 (A/Sh2/2013) and H7N7 virus challenge. HA1 region of both H7N7 and H7N9 viruses are differ at 15 amino acid positions. Among those, we selected three amino acid positions (T143, T198 and I211) in HA1 region of H7N7. These amino acids are located within or near the receptor binding site. Following the selection, we substituted the amino acid at these three positions with amino acids found on H7N9HA wild-type. In this study, we evaluate the impact of amino acid substitutions in the H7N7 HA-protein on the immunogenicity. We generated six mutant constructs from wild-type influenza H7N7HA cDNA by site directed mutagenesis, and individually expressed mutant HA protein on the surface of baculovirus (Bac-HAm) and compared their protective efficacy of the vaccines with Bac-H7N7HA wild-type (Bac-HA) by lethal H7N7 viral challenge in a mouse model. We found that mice immunized subcutaneously with Bac-HAm constructs T143A or T198A-I211V or I211V-T143A serum showed significantly higher hemagglutination inhibition and neutralization titer against H7N7 and H7N9 viruses when compared to Bac-HA vaccinated mice groups. We also observed low level of lung viral titer, negligible weight loss and complete protection against lethal H7N7 viral challenge. Our results indicated that amino acid substitution at position 143 or 211 improve immunogenicity of H7N7HA vaccine against H7N7/NL/219/03 virus.
A 40nm 650Mhz 0.5fJ/Bit/Search TCAM Compiler Using Complementary Bit-cell Architecture (2013)

Ternary content addressable memory (TCAM) is used for high-speed table lookups. The dynamic power consumption of TCAMs is one of the main challenges for keeping up with high performance requirements. System level reliability is impacted by devices that produces large peak current demands on the power grid. This paper presents a TCAM compiler based on a static complementary TCAM bitcell for reduced dynamic power and reduced decoupling capacitance(dcap) requirement. The two stage architecture comprise of static TCAM cells with a match forward feature and then a static AND-tree structure. This TCAM compiler configurations have been implemented on 40nm CMOS technology testchip and experimental results demonstrate the performance upto 650Mhz and 0.5fJ/bit/search energy for a 512wordsx256bit macro.
Microbiota control immune regulation in humanized mice (2017)

The microbiome affects development and activity of the immune system, and may modulate immune therapies, but there is little direct information about this control in vivo. We studied how the microbiome affects regulation of human immune cells in humanized mice. When humanized mice were treated with a cocktail of 4 antibiotics, there was an increase in the frequency of effector T cells in the gut wall, circulating levels of IFN-γ, and appearance of anti-nuclear antibodies. Teplizumab, a non-FcR-binding anti-CD3ε antibody, no longer delayed xenograft rejection. An increase in CD8+ central memory cells and IL-10, markers of efficacy of teplizumab, were not induced. IL-10 levels were only decreased when the mice were treated with all 4 but not individual antibiotics. Antibiotic treatment affected CD11b+CD11c+ cells, which produced less IL-10 and IL-27, and showed increased expression of CD86 and activation of T cells when cocultured with T cells and teplizumab. Soluble products in the pellets appeared to be responsible for the reduced IL-27 expression in DCs. Similar changes in IL-10 induction were seen when human peripheral blood mononuclear cells were cultured with human stool samples. We conclude that changes in the microbiome may impact the efficacy of immunosuppressive medications by altering immune regulatory pathways.
PZT MIM Capacitor With Oxygen-Doped Ru-Electrodes for Embedded FeRAM Devices (2005)

An add-on-type, Pb(Zr,Ti)O/sub 3/ (PZT) metal-insulator- (MIM) capacitor on Al multilevel interconnects is developed for embedded FeRAM devices, concluding that the oxygen-doping into the ruthenium (Ru) electrodes is crucial for obtaining large remnant polarization under a limited process temperature below 450/spl deg/C. The oxygen-doped, Ru bottom-electrode with a granular structure reduces the PZT sputtering temperature below 450/spl deg/C to obtain the ferroelectric perovskite-phase. On the other hand, oxygen doping into the Ru top-electrode suppresses the reductive damage at the interface between the top-electrode and the PZT, keeping the leakage current low. The PZT MIM capacitor with these oxygen-doped, Ru electrodes exhibits the remnant polarization of 21 /spl mu/C/cm/sup 2/ on the Al multilevel interconnects with no degradation of the interconnect reliability, thus applicable to the embedded FeRAM in 0.25 /spl mu/m-CMOS logic LSIs.
Optics for Images at Low Light Levels (2013)

This chapter contains sections titled: Introduction Light intensification devices A case apart: the SWIR band The 3-5 µm and 8-12 µm bands The future
Evaluation of biologic activity of tryptase secreted from blast cells in acute myeloid leukemia (2006)

A number of autocrine and paracrine growth regulators are considered to be involved in the survival and proliferation of blast cells in acute myeloid leukemia (AML). We have recently shown that blast cells in a group of patients with AML produce and secrete the mitogenic enzyme tryptase. In the present study, we examined functional effects of tryptase in the context of AML. As assessed by 3H-thymidine uptake experiments, tryptase-containing serum from patients with AML as well as heparin-complexed recombinant tryptase were found to promote the proliferation of cultured bone marrow- and lung fibroblasts in a dose-dependent manner. A neutralizing antibody against human beta-tryptase was found to diminish these growth-stimulatory effects of serum-tryptase in all patients examined. Tryptase also induced the expression of mRNA for GM-CSF and SCF, two cytokines known to promote growth of AML cells, in cultured bone marrow fibroblasts. Neither recombinant tryptase nor tryptase-rich serum of AML patients, showed an effect on the growth of leukemic blast cells irrespective of the FAB category or expression of protease-activated receptor (PAR)-2, a putative molecular target of tryptase. Together, tryptase is secreted from AML blasts as a biologically active molecule that may exhibit paracrine rather than autocrine effects in AML.
Guest Editorial Foreword to the Special Issue of the XIII Symposium on Virtual and Augmented Reality (2011)

This special issue of the JIS (SBC Journal on 3D Interactive Systems) is in the second year acknowledging the best papers of the Symposium on Virtual and Augmented Reality. In the SVR 2011 several interesting research projects in the field of Virtual and Augmented Reality appeared and among the best papers this issue presents two selected papers for the readers of JIS. The SVR is the most important event on Virtual and Augmented Reality in Brazil, which is being conducted by academic professionals’ members of the Brazilian Computer Society (SBC) that is supporting the conference for many years. The two papers in this issue were selected among the best papers presented at the SVR 2011. Although the technical implementation of the papers is different each other, they try to solve problems of communication and location. It is possible to note that the virtual and augmented reality is really changing our life style, and these papers show important ideas that can be directly applied by people around the world. The paper “xGroupware: Supporting Collaborative Cross-Reality Environments using Multiagents System” authored by Katia Vega, Débora Cardador, Hugo Fuks and Carlos Lucena, presents very modern proposals of meetings, combining the virtual and real in a way that users can really take advantage of the resources available to improve their communication. It is also important to say that the clever idea to use multi agents in the system as an autonomous way to perceive and interact with the situations of the meetings is amazing. Finally the integration of wearable computing devices in the system makes it very interesting and probably reflects meetings of the future. The second paper “A Case Study of Augmented Reality for Mobile Platforms” authored by Gabriela Tinti Vasselai, Dalton Solano dos Reis and Paulo Cesar Rodacki Gomes presents how the mobile devices can contribute to help our localization with the resources of augmented reality. The paper shows that the resources available in the mobile devices can be used to augmented reality purposes although some improvements in the mobile platforms must be done. We would like to thank all the reviewers of the process, the editors and staff that supported us with the submission system, and of course the authors that had to extend and adapt their papers in order to have some new content that makes this special issue an important reference point for virtual and augmented reality research.
Extended Perceptual Learning Results in Substantial Recovery of Positional Acuity and Visual Acuity in Juvenile Amblyopia (2007)

The results show that in two juvenile amblyopes, perceptual learning extended over an accumulated dosage of approximately 50 hours may be an efficient and effective adjunct to occlusion for reversing amblyopia. When combined with occlusion, perceptual learning may significantly speed up the time to recovery in children with amblyopia.
Photon-limited Cherenkov imaging of radiation therapy dose (2023)

Cherenkov imaging is a unique verification tool that could provide both dosimetric and tissue functional information during radiation therapy. However, the number of interrogated Cherenkov photons in tissue is always limited and tangled with stray radiation photons, severely frustrating the measurement the signal-to-noise ratio (SNR). As such, here, a noise-robust photon-limited imaging technique is proposed by comprehensively exploiting the physical rationale of low-flux Cherenkov measurements together with the spatial correlations of the objects. Validation experiments confirmed that the Cherenkov signal could be promisingly recovered with high SNR by irradiating at as few as one x ray pulse from a linear accelerator (10 mGy dose), and the Cherenkov excited luminescence imaging depth can be extended by >100% on average, for most concentrations of phosphorescent probe. This approach demonstrates that improved applications in radiation oncology could be seen when signal amplitude, noise robustness, and temporal resolution are comprehensively considered in the image recovery process.
Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection (1999)

Infection by the human immunodeficiency virus (HIV) either upregulates or downregulates the expression of several cytokines and interferons (IFNs) that use the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway for signal transduction. However, very little is known on the state of activation of the JAK/STAT pathway after HIV infection either in vivo or in vitro. In this regard, we report here that a constitutive activation of a C-terminal truncated STAT5 (STAT5▵) and of STAT1 occurs in the majority (∼75%) of individuals with progressive HIV disease. We have further demonstrated that, among peripheral blood mononuclear cells (PBMCs), STAT5▵ is activated preferentially in CD4+ T cells. In contrast to a published report, expression of STATs from PBMCs of infected individuals was comparable with that of seronegative donors. In addition, in vitro infection of mitogen-activated PBMCs with a panel of laboratory-adapted and primary HIV strains characterized by differential usage of chemokine coreceptors did not affect STAT protein levels. However, enhanced activation of STAT was observed after in vitro infection of resting PBMCs and nonadherent PBMCs by different viral strains. Thus, constitutive STAT activation in CD4+T lymphocytes represents a novel finding of interest also as a potential new marker of immunological reconstitution of HIV-infected individuals.
Role of Wireless Communication in Healthcare System to Cater Disaster Situations Under 6G Vision (2020)

The natural disasters created by infectious diseases have a formidable impact on people and societies. Without affecting the city infrastructure, pandemics leave the places abandoned because of the shortage of human resources, either due to deaths, illness, or unwillingness to work because of health risks. However, providing a timely response can prevent losses from occurring due to the virus dissemination. Since the first reported case of influenza in 1918 to the current pandemic Coronavirus Disease-2019 (COVID-19), the system playing a key role in saving human lives is healthcare. Nowadays, smart healthcare system development is a popular trend and wireless communication is the backbone of such systems. To provide patients with diagnosis, treatments, and several health services both within hospitals and remotely, all the healthcare units must be equipped with advanced technologies. A rapid response unit is also required to handle the thrust of the patients and queries generated during disasters. This paper discusses healthcare communication challenges and possible solutions for early awareness and rapid response in disaster situations under the human-centric vision of sixth-generation wireless technologies.
Leptospira interrogans reduces fibrin clot formation by modulating human thrombin activity via exosite I (2015)

Pathogenic bacteria of the genus Leptospira are the etiological agents of leptospirosis, a disease that affects humans and animals worldwide. Although there are an increasing number of studies on the biology of Leptospira, the mechanisms of pathogenesis are not yet understood. We report in this work that Leptospira interrogans FIOCRUZ L1-130 virulent, M20 culture attenuated and the saprophyte L. biflexa Patoc 1 strains do not bind prothrombin. Leptospiral binding to thrombin was detected with the virulent, followed by culture-attenuated M20, and practically none was observed with the saprophyte strain. The interaction of Leptospira with thrombin mostly occurs via exosite I, with a minor participation of catalytic site, as determined by employing the thrombin inhibitors hirugen, hirudin and argatroban. Leptospira interrogans binding to thrombin inhibits its catalytic activity reducing fibrin clot formation in thrombin-catalyzed reaction of fibrinogen. This inhibition was more efficient with the virulent FIOCRUZ L1-130 than with the M20 culture attenuated, while none was seen with the saprophyte strain, suggesting that this binding might be important for bacterial virulence. This is the first study reporting the binding of pathogenic Leptospira to thrombin promoting a decrease in fibrin clotting that could lead to hemorrhage, helping bacteria dissemination.