gebhart/patrepeval huggingface dataset:
A simple general method for (radio)iodination of a phenylalanine residue in peptides: preparation of [cyclic][D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin, a peptide with extraordinary selectivity for .delta.-opioid receptors. [Erratum to document cited in CA115(7):72200f] (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleA simple general method for (radio)iodination of a phenylalanine residue in peptides: preparation of [cyclic][D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin, a peptide with extraordinary selectivity for .delta.-opioid receptors. [Erratum to document cited in CA115(7):72200f]Shubh D. Sharma, Geza Toth, and Victor J. HrubyCite this: J. Org. Chem. 1992, 57, 13, 3750Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/jo00039a052https://doi.org/10.1021/jo00039a052research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of potassium tantalum niobate films formed by metalorganic deposition (1992)

Thin films of potassium tantalum niobate, KTa0.6Nb0.4O3, with a Curie temperature of 20 °C were deposited on a variety of substrates by metalorganic deposition. These films had peak relative permittivities of 16 000 at 20 °C. Hysteresis plots of electric displacement as a function of electric field, taken at 0 °C, revealed a coercive field of 800 V/cm, a spontaneous polarization of 3.9 μC/cm2, and a remnant polarization of 0.5 μC/cm2. The hysteresis loops did not change significantly as the temperature was varied down to −100 °C.
Why Has the Number of Scientific Retractions Increased? (2013)

The increase in retracted articles appears to reflect changes in the behavior of both authors and institutions. Lower barriers to publication of flawed articles are seen in the increase in number and proportion of retractions by authors with a single retraction. Lower barriers to retraction are apparent in an increase in retraction for "new" offenses such as plagiarism and a decrease in the time-to-retraction of flawed work.
Hybrid non-uniform grid based fast global boundary conditions for concave scatterers (2004)

We present a novel fast iterative algorithm (NG fast GBC) based on a hybrid boundary integral formulation. When coupled with domain decomposition and a non-uniform polar grid interpolation scheme, it has the potential to overcome some of the limitations of local absorbing boundary condition (ABC) schemes. The algorithm applies to scattering problems for bodies with arbitrarily shaped exterior boundaries and allows significant reduction in "white space". In our formulation, the scatterer is assumed as PEC, although extension of the scheme to arbitrary local boundary conditions (e.g., impedance boundary) is quite possible. An efficient and accurate multidimensional interpolation scheme serves as key to the implementation of the method, especially if the technique is employed in a multilevel computational scheme.
Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists (2023)

Abstract Stapled α-helical peptides can bind to and modulate historically intractable targets while addressing the traditional liabilities associated with peptide therapeutics. However, their pipeline advancement has been impeded by the challenges of identifying peptides with sufficient cellular uptake to engage the target protein while lacking off-target toxicities. Here, we advance the field to arrive at a workflow for identifying advanced stapled peptide lead molecules with on-target in vivo activity with no off-target cell proliferation effects. Specifically, we generated a &gt;350-member library based on ATSP-7041, a stapled peptide Mdm2(X) antagonist with validated on-target cellular effects but with significant off-target activity. Key insights from library analysis include 1) a clear correlation between lipophilicity and permeability, 2) removal of positive charge to avoid off-target toxicities, 3) judicious placement of anionic residues to enhance peptide solubility/behavior, 4) optimization of C-terminal length and helicity to enhance cell activity, 5) optimization of staple type/number to avoid polypharmacology. Incorporation of one or more of these attributes led to molecules with improved in vitro and in vivo activities (up to a &gt;292x improved cell proliferation EC 50 ). A subset of peptides were devoid of off-target cell proliferation effects in cell lines lacking wild-type p53 protein (up to a &gt;3800x on-target index). This latter improvement contrasted with clinical Mdm2 antagonistic molecules. Application of these ‘design rules’ to a distinct Mdm2(X) peptide series resulted in rapid improvement in cellular activity (&gt;150x) and removal of off-target toxicities. Overall, the detailed workflow outlined here should help researchers identify stapled α-helical peptides for therapeutic impact.
Des Lumières à l'émigration: jalons pour une biographie de Philippe-Goswin de Neny (1740-1812) (1989)

info:eu-repo/semantics/published
[Reducing the risk of tuberculosis in children vaccinated with BCG]. (1976)

President Roosevelt provides Judge Mayer with a line to help remind Judge Holt of the previous letter.
Role of ALA sensitivity in HepG2 cell in the presence of diode laser (2011)

5-aminolevulinic acid (ALA) being an amazing second generation photosensitizer was studied as photodamaging drug on hepatocellular carcinoma (HepG2) cells. The mentioned photosensitizer is converted to PpIX in HepG2 cells in vitro, inducing haem in the cell causing generation of singlet oxygen leading to cell apoptosis. Cell uptake of 5-ALA was evaluated with different concentrations (ranging from 0–800 μg/ml) for 0–49 h incubation period. ALA administered in HepG2 cells is converted into Protoporphyrin IX (PpIX) which has a short half life and constitute a good hematoporphyrin derivative (HPD). Cytotoxicity of ALA in dark and cellular viability without ALA in the presence of light was studied, showing minimal toxic effects in dark with no photodamaging effect on mentioned cells in absence of ALA were observed. The optimal uptake of photosensitizer (5-ALA) in HepG2 cells was investigated by means of spectrophotometeric measurements, cellular viability was determined by means of neutral red assay (NRA). It was observed that with different concentrations (0–800 μg/ml) of ALA or light doses (0–160 J/cm2), there were no significant effect on cellular viability when studied independently. The novel of photocytotoxic study indicates that light dose of 120 J/cm2 produces convincing Photodynamic therapy (PDT) results for HepG2 cells incubated with 262 μg/ml of 5-ALA deducting that HepG2 cell line is sensitive to ALA mediated PDT. Finally morphological changes in HePG2 cells were determined before and after ALA-mediated PDT by confocal microscopy.
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma (2020)

BackgroundThe Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular aberrations in 487 high-grade serous ovarian cancers, with much remaining to be elucidated regarding the microRNAs (miRNAs). Here, using TCGA ovarian data, we surveyed the miRNAs, in the context of their predicted gene targets.Methods and ResultsIntegration of miRNA and gene patterns yielded evidence that proximal pairs of miRNAs are processed from polycistronic primary transcripts, and that intronic miRNAs and their host gene mRNAs derive from common transcripts. Patterns of miRNA expression revealed multiple tumor subtypes and a set of 34 miRNAs predictive of overall patient survival. In a global analysis, miRNA:mRNA pairs anti-correlated in expression across tumors showed a higher frequency of in silico predicted target sites in the mRNA 3′-untranslated region (with less frequency observed for coding sequence and 5′-untranslated regions). The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes (including DNMT3A and DNMT3B) and substantially decreased ovarian cancer cell viability.ConclusionsThis study establishes miRNAs as having a widespread impact on gene expression programs in ovarian cancer, further strengthening our understanding of miRNA biology as it applies to human cancer. As with gene transcripts, miRNAs exhibit high diversity reflecting the genomic heterogeneity within a clinically homogeneous disease population. Putative miRNA:mRNA interactions, as identified using integrative analysis, can be validated. TCGA data are a valuable resource for the identification of novel tumor suppressive miRNAs in ovarian as well as other cancers.
Design and fabrication by example (2014)

We propose a data-driven method for designing 3D models that can be fabricated. First, our approach converts a collection of expert-created designs to a dataset of parameterized design templates that includes all information necessary for fabrication. The templates are then used in an interactive design system to create new fabri-cable models in a design-by-example manner. A simple interface allows novice users to choose template parts from the database, change their parameters, and combine them to create new models. Using the information in the template database, the system can automatically position, align, and connect parts: the system accomplishes this by adjusting parameters, adding appropriate constraints, and assigning connectors. This process ensures that the created models can be fabricated, saves the user from many tedious but necessary tasks, and makes it possible for non-experts to design and create actual physical objects. To demonstrate our data-driven method, we present several examples of complex functional objects that we designed and manufactured using our system.
Joint pilot and data loading technique for MIMO systems operating with covariance feedback (2004)

We consider a multiple input multiple output (MIMO) system wherein channel correlation as well as noisy channel estimation are both taken into account. For a given block fading duration, pilot-assisted channel estimation is carried out with the aid of a minimum mean square error estimator. The pilot sequences and data are jointly optimized to maximize the ergodic capacity while fulfilling a total transmit energy constraint. Using the optimization results, we study the effect of various system parameters and different types of channel knowledge. We show that systems with channel covariance knowledge and imperfect channel estimates can even outperform those with perfect channel estimation at the receiver, but without any channel knowledge at the transmitter. Further, we show that the signal to noise ratio and the block fading duration determine the qualitative behavior of ergodic capacity as a function of antenna spacing or angular spread. Finally, we find that the optimum pilot-to-data power ratio is always greater than one. It increases as the total transmit power decreases or as the block fading length increases.
Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia (2018)

ISRCTN Registy, ISRCTN83830814.
Immunohistochemical Demonstration of Toxoplasma gondii (1981)

A peroxidase-antiperoxidase method that demonstrates both free and encysted toxoplasmata in routinely prepared histologic sections is described. This technic and ultrastructural study were employed to confirm the presence of Toxoplasma gondii in the infected tissues of an immunosuppressed patient who had postmortem examination. An immunohistochemical method may be an aid in the diagnosis of toxoplasmosis.
A Magnetic Resonance Imaging Study of Schizophrenia: Brain Structure and Clinical Symptoms (1991)

Thirty-one patients with schizophrenia and 33 normal control subjects underwent MRI. The BPRS was used to rate clinical symptoms and the NART to estimate pre-morbid IQ. All were right handed. The temporal lobe was significantly smaller on the left than the right in both the control and schizophrenic groups. The amygdala was smaller on the left than the right in controls but not in schizophrenics. The parahippocampal gyrus was smaller on the left side in the schizophrenic group but not in controls. In the schizophrenic group, ventricular enlargement and cerebral atrophy were significantly related to severity of symptoms. Patients with marked negative symptoms had a bilateral reduction in the size of the head of caudate and the two measures were significantly correlated. Patients with marked positive symptoms had larger VBRs and again the clinical and morphometric changes were significantly correlated. There were no morphometric differences between patients with short duration (two years or less) and chronic symptoms.
Cultivating research taste (illustrated via a journey in program synthesis research) (2015)

No abstract available.
D2.5 Advanced Business Models for IoT Services (2023)

The following document, D2.5, is the second deliverable of Task 2.3 and the last deliverable of WP2. The document first describes the iNGENIOUS ecosystem, that is, the different actors involved in the project and their role in the end-to-end IoT chain. Later on, the document focuses on an advanced business analysis of the IoT solutions for verticals. The objective of this document is to provide a wider overview of the market and complete the information provided in D2.3. Specifically, it provides an analysis on the business vision of vertical stakeholders (consortium members, AB, and external NG-IoT projects), and also by the IoT solution providers that are part of the iNGENIOUS consortium. Such vision has been obtained through two different questionnaires containing a wide variety of topics related to IoT and its ecosystem. The main idea is to compare both views and understand if our consortium is aligned with the stakeholders’ perspective and the maturity of our portfolio is enough for the services expected.
Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7 (2014)

Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and activation of the receptor regulates the release of both glutamate and GABA. mGlu7 is thought to be a relevant therapeutic target for a number of neurological and psychiatric disorders, and polymorphisms in the GRM7 gene have been linked to autism, depression, ADHD, and schizophrenia. Here we report two new pan-group III mGlu positive allosteric modulators, VU0155094 and VU0422288, which show differential activity at the various group III mGlus. Additionally, both compounds show probe dependence when assessed in the presence of distinct orthosteric agonists. By pairing studies of these nonselective compounds with a synapse in the hippocampus that expresses only mGlu7, we have validated activity of these compounds in a native tissue setting. These studies provide proof-of-concept evidence that mGlu7 activity can be modulated by positive allosteric modulation, paving the way for future therapeutics development.
Improved Retention Characteristic in Polycrystalline Silicon–Oxide–Hafnium Oxide–Oxide–Silicon-Type Nonvolatile Memory with Robust Tunnel Oxynitride (2011)

In this paper, we present a simple novel process for forming a robust and reliable oxynitride dielectric with a high nitrogen content. It is highly suitable for n-channel metal–oxide–semiconductor field-effect transistor (nMOSFETs) and polycrystalline silicon–oxide–hafnium oxide–oxide–silicon (SOHOS)-type memory applications. The proposed approach is realized by using chemical oxide with ammonia (NH 3 ) nitridation followed by reoxidation with oxygen (O 2 ). The novel oxynitride process is not only compatible with the standard complementary metal–oxide–semiconductor (CMOS) process, but also can ensure the improvement of flash memory with low-cost manufacturing. The characteristics of nMOSFETs and SOHOS-type nonvolatile memories (NVMs) with a robust oxynitride as a gate oxide or tunnel oxide are studied to demonstrate their advantages such as the retardation of the stress-induced trap generation during constant-voltage stress (CVS), the program/erase behaviors, cycling endurance, and data retention. The results indicate that the proposed robust oxynitride is suitable for future nonvolatile flash memory technology application.
Preliminary Back-Analysis of the Height of Mud Brick Fortifications Based on Geoarchaeological Data at Tell El-Retaba Site in Egypt (2017)

Abstract The Tell el-Retaba archaeological site is located at Wadi Tumilat, a shallow valley running from the Nile Delta to the Bitter Lakes. In ancient times, a route connecting Egypt with Syria-Palestine ran across the site. In the 13 th century BC, during the rule of Ramesses II, a fortress surrounded by “Wall 1” was erected and in times of Ramesses III in the 12 th century BC, a larger fortress surrounded by “Wall 2” and “Wall 3” was constructed. Using the finite element method (FEM) and ZSoil 2D&amp;3D software, the wall heights were modelled and their soil-structure interaction was analysed. Strength of the wall depended on size and strength of bricks and mortar, brickwork, wall shape and foundation. Ancient builders using mud bricks must have known from practical experience the essentials of a wall construction, in which the height to width ratio was at 1.75 to 1.85. Moreover, they must have related the engineering properties of the material with the height of the construction and its purpose. The width to height ratio must have been used and related by ancient Egyptians to the ground resistance. Modelling has shown that, at wall width of 5 m, the foundation would have lost its stability at wall height of 13–14 m and bricks from the lower part of the wall would be destroyed. According to the undertaken assumptions, in order to retain stability, the wall height must have been limited to about 8–9 m.
Self Organizing Maps for the Visual Analysis of Pitch Contours (2015)

We present a novel interactive approach for the visual analysis of intonation contours.Audio data are processed algorithmically and presented to researchers through interactive visualizations.To this end, we automatically analyze the data using machine learning in order to find groups or patterns.These results are visualized with respect to meta-data.We present a flexible, interactive system for the analysis of prosodic data.Using realworld application examples, one containing preprocessed, the other raw data, we demonstrate that our system enables researchers to interact dynamically with the data at several levels and by means of different types of visualizations, thus arriving at a better understanding of the data via a cycle of hypothesis generation and testing that takes full advantage of our visual processing abilities.
Thermal degradation of indium-tin-oxide/p-silicon solar cells (1980)

Thermal degradation of indium-tin-oxide (ITO)/p-silicon solar cells has been investigated for cells fabricated on both single and polycrystalline silicon. The primary thermal degradation mechanisms was found to be the growth of SiO2 at the ITO/silicon interface resulting from oxygen diffusion through the ITO and not decomposition of the ITO. The degradation rate appears to be limited by surface reaction controlled oxidation since this rate is independent of ITO thickness. The polycrystalline cells were observed to degrade somewhat faster than the single-crystalline cells. The projected cell life at 50 °C due to thermal failure mechanisms exceeds 105 years for both single-crystal and polycrystalline cells.
Gaze Speedup: Eye Gaze Assisted Gesture Typing in Virtual Reality (2023)

Mid-air text input in augmented or virtual reality (AR/VR) is an open problem. One proposed solution is gesture typing where the user performs a gesture trace over the keyboard. However, this requires the user to move their hands precisely and continuously, potentially causing arm fatigue. With eye tracking available on AR/VR devices, multiple works have proposed gaze-driven gesture typing techniques. However, such techniques require the explicit use of gaze which are prone to Midas touch problems, conflicting with other gaze activities in the same moment. In this work, the user is not made aware that their gaze is being used to improve the interaction, making the use of gaze completely implicit. We observed that a user’s implicit gaze fixation location during gesture typing is usually the gesture cursor’s target location if the gesture cursor is moving toward it. Based on this observation, we propose the Speedup method in which we speed up the gesture cursor toward the user’s gaze fixation location, the speedup rate depends on how well the gesture cursor’s moving direction aligns with the gaze fixation. To reduce the overshooting near the target in the Speedup method, we further proposed the Gaussian Speedup method in which the speedup rate is dynamically reduced with a Gaussian function when the gesture cursor gets nearer to the gaze fixation. Using a wrist IMU as input, a 12-person study demonstrated that the Speedup method and Gaussian Speedup method reduced users’ hand movement by and respectively without any loss of typing speed or accuracy.
White phosphorescent organic light emitting devices for lighting applications (2006)

Consumer display manufacturers are increasingly interested in white organic light emitting devices (WOLEDs), because these devices offer thinner display profiles, and in combination with color filters eliminate the need for high-resolution shadow masks. Additionally, WOLEDs are well suited for general-purpose illumination, since the power efficiencies of laboratory devices have surpassed that of today's commercial incandescent bulbs. In this paper, we report on an all phosphorescent 25 cm<sup>2</sup> WOLED lighting system that achieves (31±3) lm/W at 850 cd/m<sup>2</sup> with CIE coordinates (0.37, 0.36), and an external quantum efficiency of (29±3)%.