gebhart/patrepeval huggingface dataset:
Polymeric and Molecular Materials for Advanced Organic Electronics (2011)

Abstract : During the project period, we made strong progress in: I) organic semiconductors, 2) gate dielectrics, and 3) fundamental studies of charge transport. In 1), we expanded our understanding of the architectural and electronic structure requirements for n-type semiconductors and the role grain boundaries play in transport. To accomplish this, we developed new synthetic routes to processable small molecules and polymers, and characterized/optimized structural, electronic, and processing properties. In 2), we expanded the SAND (self-assembled nanodielectric) concept to vapor-deposited (V-SAND) and to spin-coated. printable variants. All have excellent dielectric and insulating properties, a remarkable ability to minimize trapped charge between thin film transistor dielectric and semiconductor layers, and because of the high capacitances, lowe red transistor operating voltages. These characteristics enable many new types of devices with outstanding performance, such as transparent and flexible transistors. In 3), we showed via variable-temperature studies that transport mechanisms involve multiple trapping and release mechanisms which are sensitive to the semiconductor film processing and the gate dielectric.
Composite measurements and molecular compressed sensing for highly efficient transcriptomics (2017)

Abstract RNA profiling is an excellent phenotype of cellular responses and tissue states, but can be costly to generate at the massive scale required for studies of regulatory circuits, genetic states or perturbation screens. Here, we draw on a series of advances over the last decade in the field of mathematics to establish a rigorous link between biological structure, data compressibility, and efficient data acquisition. We propose that very few random composite measurements – in which gene abundances are combined in a random linear combination – are needed to approximate the high-dimensional similarity between any pair of gene abundance profiles. We then show how finding latent, sparse representations of gene expression data would enable us to “decompress” a small number of random composite measurements and recover high-dimensional gene expression levels that were not measured (unobserved). We present a new algorithm for finding sparse, modular structure, which improves the ability to interpret samples in terms of small numbers of active modules, and show that the modular structure we find is sufficient to recover gene expression profiles from composite measurements (with ~100-fold fewer composite measurements than genes). Moreover, the knowledge that sparse, modular structures exist allows us to recover expression profiles from composite measurements, even without access to any training data. Finally, we present a proof-of-concept experiment for making composite measurements in the laboratory, involving the measurement of linear combinations of RNA abundances. Altogether, our results suggest new compressive modalities in experimental biology that can form a foundation for massive scaling in high-throughput measurements, while also offering new insights into the interpretation of high-dimensional data.
Particle Production in Reflection and Transmission Mode Laser Ablation: Implications for Laserspray Ionization (2013)

Particles were ablated from laser desorption and inlet ionization matrix thin films with a UV laser in reflection and transmission geometries. Particle size distributions were measured with a combined scanning mobility particle sizer (SMPS) and aerodynamic particle sizer (APS) system that measured particles in the size range from 10 nm to 20 μm. The matrixes investigated were 2,5-dihydroxybenzoic acid (DHB), α-cyano-4-hydroxycinnamic acid (CHCA), sinapic acid (SA), 2,5-dihydroxy-acetophenone (DHAP), and 2-nitrophloroglucinol (NPG). Nanoparticles with average diameters between 20 and 120 nm were observed in both transmission and reflection geometry. The particle mass distribution was significantly different in reflection and transmission geometry. In reflection geometry, approximately equal mass was distributed between particles in the 20 to 450 nm range of diameters and particles in the 450 nm to 1.5 μm diameter range. In transmission mode, the particle mass distribution was dominated by large particles in the 2 to 20 μm diameter range. Ablation of inlet ionization matrices DHAP and NPG produced particles that were 3 to 4 times smaller compared with the other matrices. The results are consistent with ion formation by nanoparticle melting and breakup or melting and breakup of the large particles through contact with heated inlet surfaces. ᅟ
Applications of microarray in reproductive medicine. (2006)

In the genomic era, cDNA microarray (DNA chip) technology has become a very important and powerful tool for high-throughput comprehensive analysis of gene expression, genotyping and re-sequencing applications in almost every field of biomedical research. Large-scale transcriptional profiling analyses using microarrays are frequently used to explore gene expression patterns in order to better understand the molecular mechanisms of physiology and pathogenesis: these are the basis for the development of new diagnostic and therapeutic strategies. Recently, this powerful technique has been used with laser capture microdissection (LCM) and linear aRNA amplification (in vitro transcription), and used in reproductive medical research. Recent studies of microarray-related techniques used to study oocyte fertilization, early embryo development, implantation and some infertility-related diseases (endometriosis and myoma) are discussed and summarized in this review.
Mosaic HIV envelope immunogenic polypeptides (2023)

Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.
Experiments with Undulator Radiation, Emitted by a Single Electron (2022)

We study a single electron, circulating in the Fermilab IOTA storage ring and interacting with an undulator through single and multi-photon emissions. The focus of this research is on single-photon and two-photon undulator emissions. We begin by using one Single Photon Avalanche Diode (SPAD) detector to detect the undulator radiation photons and search for possible deviations from the expected Poissonian photon statistics. Then, we go on to use a two-photon interferometer consisting of two SPAD detectors separated by a beam splitter. This allows to test if there is any correlation in the detected photon pairs. In addition, the photocount arrival times can be used to track the longitudinal motion of a single electron and to compare it with simulations. This allowed us to determine several dynamical parameters of the storage ring such as the rf cavity phase jitter and the dependence of the synchrotron motion period on amplitude.
Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG) (2007)

Because nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) express CD20, rituximab may be used as a nonmutagenic treatment option to avoid late toxicities in this rather indolent entity. Between 1999 and 2004, the German Hodgkin Study Group (GHSG) investigated the activity of rituximab (375 mg/m(2) in 4 doses) in a phase 2 trial in 21 relapsed or refractory NLPHL patients. The initial diagnosis of NLPHL was confirmed in 15 of the 21 enrolled patients by reference pathology. The remaining cases were reclassified as Hodgkin lymphoma transformed to T-cell rich B-cell lymphoma (TCRBCL; n = 2) or CD20(+) classical Hodgkin lymphoma (cHL; n = 4). In NLPHL patients the overall response rate was 94%, including 8 complete remission (CR) and 6 partial remission (PR). With a median follow-up of 63 months (range, 3-84), the median time to progression was 33 months, with the median overall survival (OS) not reached. Thus, rituximab is highly effective in relapsed and refractory NLPHL. This study is registered at http://www.klinisches-studienzentrum.de/trial/285.
Severe hypohidrotic ectodermal dysplasia in a girl caused by a de novo 9;X insertion that includes XIST and disrupts the EDA gene (2007)

X-linked hypohidrotic ectodermal dysplasia (XLHED) is caused by mutations in the EDA gene. A girl with severe hypohidrotic ectodermal dysplasia and normal mental development had completely skewed X chromosome inactivation with only the paternal X active in peripheral blood cells. Routine chromosome analysis and sequencing of the EDA gene were normal. However, whole chromosome painting revealed a 9;X insertion. FISH analyses with BAC probes towards the EDA gene and the more distal region containing the XIST locus showed that an X chromosome fragment of at least 4 Mb containing XIST was inserted into 9p13 in conjunction with a de novo pericentric inversion of chromosome 9. The proximal breakpoint was within the EDA gene and the distal breakpoint was distal to the XIST locus. Both parents had normal chromosomes, and the mother had random X inactivation in peripheral blood cells. Because XIST was lacking on the X chromosome with the disrupted EDA gene, the normal X chromosome was inactivated resulting in severe XLHED.
SMAD3 promotes expression and activity of the androgen receptor in prostate cancer (2023)

Overexpression of androgen receptor (AR) is the primary cause of castration-resistant prostate cancer, although mechanisms upregulating AR transcription in this context are not well understood. Our RNA-seq studies revealed that SMAD3 knockdown decreased levels of AR and AR target genes, whereas SMAD4 or SMAD2 knockdown had little or no effect. ChIP-seq analysis showed that SMAD3 knockdown decreased global binding of AR to chromatin. Mechanistically, we show that SMAD3 binds to intron 3 of the AR gene to promote AR expression. Targeting these binding sites by CRISPRi reduced transcript levels of AR and AR targets. In addition, ∼50% of AR and SMAD3 ChIP-seq peaks overlapped, and SMAD3 may also cooperate with or co-activate AR for AR target expression. Functionally, AR re-expression in SMAD3-knockdown cells partially rescued AR target expression and cell growth defects. The SMAD3 peak in AR intron 3 overlapped with H3K27ac ChIP-seq and ATAC-seq peaks in datasets of prostate cancer. AR and SMAD3 mRNAs were upregulated in datasets of metastatic prostate cancer and CRPC compared with primary prostate cancer. A SMAD3 PROTAC inhibitor reduced levels of AR, AR-V7 and AR targets in prostate cancer cells. This study suggests that SMAD3 could be targeted to inhibit AR in prostate cancer.
Controlling Quantum Devices with Nonlinear Hardware (2015)

To achieve high-fidelity, coherent control of quantum systems via imperfect classical hardware, the authors provide a general framework for designing control sequences that account for distortions---even those that are nonlinear and noninvertible. These sequences are robust to both a distribution of device Hamiltonians (such as for spatially varying fields) and uncertainties in the description of the control hardware itself, greatly extending the bounds of quantum device operation.
WPT System in Seawater for AUVs with kW-class Power, High Positional Freedom, and High Efficiency inside the Transfer Coils (2022)

An autonomous underwater vehicle can move freely in the sea. These are used to explore marine resources, survey marine organisms, and monitor infrastructure facilities. In the future, with the development of the marine industry, the range of use is expected to expand further. To efficiently utilize the mobile underwater body, a system that can supply power in the sea without pulling it up from the sea is desired. We have proposed wireless power transfer with receiving power of3 kW, a maximum power transfer efficiency of about 80 %, and a degree of freedom of position of several meters.
Regenerative Nano‐Hybrid Coating Tailored for Autonomous Corrosion Protection (2015)

A novel bilayer coating system for autonomous corrosion-triggered self-healing is demonstrated. The storage of the encapsulated monomer and the catalyst is separated in two different layers. The encapsulated catalyst is stored inside a metallic coating, which ensures its activity even for an extended exposure time. The release from the capsules is triggered by corrosion and the correlated pH increase.
Register Pointer Architecture for Efficient Embedded Processors (2007)

Conventional register file architectures cannot optimally exploit temporal locality in data references due to their limited capacity and static encoding of register addresses in instructions. In conventional embedded architectures, the register file capacity cannot be increased without resorting to longer instruction words. Similarly, loop unrolling is often required to exploit locality in the register file accesses across iterations because naming registers statically is inflexible. Both optimizations lead to significant code size increases, which is undesirable in embedded systems. In this paper, the authors introduce the register pointer architecture (RPA), which allows registers to be accessed indirectly through register pointers. Indirection allows a larger register file to be used without increasing the length of instruction words. Additional register file capacity allows many loads and stores, such as those introduced by spill code, to be eliminated, which improves performance and reduces energy consumption. Moreover, indirection affords additional flexibility in naming registers, which reduces the need to apply loop unrolling in order to maximize reuse of register allocated variables
Automatic Generation of Two-Party Computations (Extended Abstract) (2003)

We present the design and implementation of a compiler that automatically generates protocols that perform two-party computations. The input to our protocol is the specification of a computation with secret inputs (e.g., a signature algorithm) expressed using operations in the field Zq of integers modulo a prime q and in the multiplicative subgroup of order q in Z # p for q|p 1 with generator g. The output of our compiler is an implementation of each party in a two-party protocol to perform the same computation securely, i.e., so that both parties can together compute the function but neither can alone. The protocols generated by our compiler are provably secure, in that their strength can be reduced to that of the original cryptographic computation via simulation arguments. Our compiler can be applied to various cryptographic primitives (e.g., signature schemes, encryption schemes, oblivious transfer protocols) and other protocols that employ a trusted party (e.g., key retrieval, key distribution).
Lysine Residues in Bee Venom Phospholipase A<sub>2</sub> Are Important for Binding to Human Monoclonal or Polyclonal Antibodies of the lgG4 Isotope (1994)

Discontinuous antigenic sites on bee venom phospholipase A2 (PLA) have been mapped using human monoclonal antibodies or human polyclonal serum antibodies (hpAbs) of the IgG4 isotype from beekeepers or of the IgE isotype from individuals allergic to PLA. Lysine residues of PLA have been specifically modified by acetylation or acylation by treatment with citraconic anhydride of their epsilon-amino groups to analyze their role in antigen-antibody binding. After the modifications, the binding of PLA to the human monoclonal antibodies is lost, whereas the binding to IgG4 hpAbs is significantly decreased. In contrast, the effect on the binding of PLA to IgE hpAbs appears to be more heterogeneous. The data indicate the importance of lysine residues as being part of B cell epitopes in PLA-specific antibodies of the IgG4 isotype, but less so for those of the IgE isotype.
ChemInform Abstract: Acid‐Catalyzed E‐Ring Expansion and Isomerization of 3‐Acetylbetulin: Synthesis of Cytotoxic Anhydrobetulin Saponins. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design of a Catheter-Based Device for Performing Percutaneous Chordal-Cutting Procedures (2009)

This paper focuses on the design and implementation of a percutaneous catheter-based device to provide physicians with an externally controlled tool capable of manipulating and cutting specific chordae tendinae within the hear to alleviate problems associated with some forms of mitral valve regurgitationt. In the United States alone, approximately 500,000 people develop ischemic or functional MR per year, and the chordae tendinae cutting procedure and device are needed because many patients do not have the required level of health necessary to survive open-heart surgery. A deterministic design process was used to generate several design concepts and then evaluate and compare each concept based on a set of functional requirements. A final concept to be alpha prototyped was then chosen, further developed, and fabricated. Experiments showed that the design was capable of locating and grabbing a chord and that ultrasound imaging is a viable method for navigating the device inside of the human body. Once contact between the chord and an RF ablator tip was confirmed, the chord was successfully ablated.
Model-based decentralised automatic management of product flow paths in processing plants (2010)

This work introduces the model of product flow paths as a formal framework for the correct execution of product flow operations in processing plants. A product flow path is a software object responsible for controlling, monitoring and documenting the movement of products along a determined route in the plant, and represents a temporarily and spatially isolated area for the safe and correct transport of products. A formal model provides a guide for the implementation of decentralised object-oriented product flow path management systems. A model-based synthesis technique replaces the engineering of a flow path management system for a plant with the simpler task of creating and verifying a model of the plant. A prototypical implementation of this technology has been developed as a proof of concept and tested with real-life plants, and can be seen as a reference implementation for industrial-strength flow path management systems.
Spatial‐Frequency‐Tuned Markers and Adaptive Correction for Rotational Motion (1995)

A common type of motion present in clinical magnetic resonance imaging examinations is rotational motion, such as that due to voluntary motion during head examinations. The correction scheme presented in this work offers a method for eliminating the effects of rotations within the imaging plane. Integral to the implementation of this technique is the concept and design of spatial-frequency-tuned markers, which are used to track the rotational motion. These studies showed that it is possible to accurately track the motion, measuring both axis and angle of rotation, and use this information to retrospectively correct the acquired images. These markers can also provide information about any translational motion present. The resulting images show a marked decrease in artifacts and improved clarity.
Epidural and intrathecal opiates: Cerebrospinal fluid and plasma profiles in patients with chronic cancer pain (1985)

We studied the cerebrospinal fluid (CSF) and plasma concentration-time profiles of morphine, methadone, and beta-endorphin after lumbar epidural or intrathecal injection in 17 patients with cancer. After epidural injection, all three drugs reached peak levels in lumbar CSF within 34 minutes that were 50 to 1300 times higher than free drug concentrations in plasma. The rate of decline of CSF levels correlated with drug lipid solubility (methadone [t1/2 = 73 minutes] greater than morphine [126 minutes] greater than beta-endorphin [317 minutes]). Plasma levels were comparable with those after intragluteal injection of the same dose. In four patients given intrathecal morphine or methadone, CSF at the C1-2 level contained high levels of morphine as early as 1 hour after injection, but levels of methadone were lower or undetectable. Three of 17 patients reported improved analgesia initially, but none were improved at 2 weeks after chronic therapy. We conclude that analgesia induced by intrathecal or epidural morphine injections is caused by drug acting at both spinal and supraspinal sites. The use of spinal opiates such as morphine is of limited value in patients whose pain is not adequately managed by high systemic doses of morphine-like drugs.
A perspective on catalytic production of olefinic compounds from biomass (2023)

Key reactions and possible biomass resources for the synthesis of industrially important unsaturated compounds are summarized.
Noninvasive Quantification of Hepatic Fat Content Using Three-Echo Dixon Magnetic Resonance Imaging With Correction for T2* Relaxation Effects (2011)

T2*-corrected Dixon MRI is a noninvasive tool for estimating HFC, showing excellent correlation with liver biopsy without being limited by liver iron content and fibrosis/cirrhosis.
Bastien und Bastienne: The Libretto, Its Derivation, and Mozart's Text-Setting (1990)

Research Article| October 01 1990 Bastien und Bastienne: The Libretto, Its Derivation, and Mozart's Text-Setting Linda Tyler Linda Tyler Search for other works by this author on: This Site PubMed Google Scholar Journal of Musicology (1990) 8 (4): 520–552. https://doi.org/10.2307/763534 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Linda Tyler; Bastien und Bastienne: The Libretto, Its Derivation, and Mozart's Text-Setting. Journal of Musicology 1 October 1990; 8 (4): 520–552. doi: https://doi.org/10.2307/763534 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentJournal of Musicology Search This content is only available via PDF. Copyright 1990 Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.