gebhart/patrepeval huggingface dataset:
High Efficiency Red Phosphorescent Organic Light Emitting Diodes with Single Quantum Well Structure (2010)

Abstract We report highly efficient red phosphorescent organic light-emitting diodes with a triplet p-i-n single quantum well (QW) structure. This p-i-n single QW structure is realized using p-doped and n-doped wide band-gap hole and electron injection and transporting layers with narrow band-gap host and dopant materials. The maximum current and power efficiencies of 11.1 cd/A and 14.4 lm/W, respectively, are demonstrated by a good carrier confinement effect of QW. Very low driving voltage characteristics of 3.7 ∼ 3.9 V at 1000 cd/m2 are realized by almost no injection barrier with high conductivity configuration in our p-i-n structure. Keywords: Exciton confinementnarrow band-gaporganic light-emitting diodephosphorescencequantum wellwide band-gap Acknowledgments This work is the outcome of a Manpower Development Program for Energy & Resources supported by the Ministry of Knowledge and Economy (MKE).
Table S6 from RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3 (2023)

&lt;p&gt;Cox regression analysis of potential poor prognostic factors for patients with colorectal cancer, (Beijing cohort 1, n=111)&lt;/p&gt;
Reviews (2001)

Lisa Tyler. Writing and Healing: Toward an Informed Practice. (Charles M. Anderson and Marian M. MacCurdy, eds., 2000). Fran Claggett. Revisioning Writers' Talk: Gender and Culture in Acts of Composing. (Mary Ann Cain, 1995). Bruce Novak. Tomorrow's Children: A Blueprint for Partnership Education in the 21st Century. (Riane Eisler, 2000). Neal Lerner. Stories from the Center: Connecting Narrative and Theory in the Writing Center. (Lynn Craigue Briggs and Meg Woolbright, eds., 2000).
Identification of glioma‐specific RFX4‐E and ‐F isoforms and humoral immune response in patients (2005)

For regulatory factor X4 (RFX4), two alternatively spliced variants, RFX4-A and -B, were reported in the testis. In this study, we identified transcript variants RFX4-C, -D, -E, and -F, and demonstrated by reverse transcription-polymerase chain reaction (RT-PCR) that RFX4-A, -B and -C mRNAs were expressed only in the testis, and RFX4-D mRNA was expressed only in normal brain tissues. In tumors, RFX4-E and -F in addition to RFX4-D mRNA were expressed in gliomas by rapid amplification of cDNA ends and RT-PCR analyses. Expression of RFX4 mRNA was not observed in other tumors, such as lung, esophageal, stomach, colon or liver cancers. Quantitative real-time RT-PCR using common primer pairs detecting all of the variant transcripts showed high expression in normal testis, low expression in the brain (1% compared to the expression in testis), and overexpression in 17 of 61 gliomas (28%). Western blot analysis using DC28 monoclonal antibody (mAb) produced against recombinant RFX4-D C-terminus protein showed expression of RFX4-A and -C proteins, but not RFX4-B protein, in the testis, and expression of RFX4-D protein in the brain. Moreover, expression of RFX4-E and -F proteins, but not RFX4-D protein, was observed in gliomas. Immunohistochemistry analysis using DC28 mAb showed positive staining in the nuclei of spermatocytes in the testis and glioma cells. Antibody against RFX4 was detected in the sera of 3 of 58 (5%) glioma patients by enzyme-linked immunosorbent assay, suggesting the immunogenicity of RFX4-E and -F proteins in glioma patients.
Chemistry, Adhesive and Composite Properties of Low Molecular Weight Phenylethynyl Terminated Oligomers (2004)

PETI-5 (1250 and 2500 g/mole) were prepared and characterized. Neat resin, adhesive and composite properties were determined and compared with those of PETI-5 (5000 g/mole). Relative to PETI-5 (5000 g/mole), PETI-5 (2500 g/mole) exhibited improved processability and equivalency in the adhesive and composite properties measured thus far. This resin, in both adhesive film and prepreg form, has the potential to offer significant improvements in the processing of complex structural composite parts.
A low-power FSK/spatial modulation transmitter for mm-wave wireless links (2017)

Energy-efficient, multi-Gb/s wireless links are of interest for short-range board-to-board links within server chassis/enclosed server platforms. In this paper, we propose to leverage the small physical size/large available bandwidth of mm-wave systems to demonstrate combined frequency and spatial modulation in a mm-wave TX, targeting links operating in slow-varying channels. A pulsed mm-wave digitally-controlled oscillator (DCO) provides low-power FSK capability, while variable pulse trigger delay achieves controlled relative phase between TX elements for low-power space-shift keying (SSK). A two-element 65-nm CMOS TX prototype is packaged with PCB antennas to demonstrate a 2-FSK/4-SSK 3-Gb/s TX up to 60-cm with 21.4 mW power consumption, achieving ~7.1 pJ/bit.
Use of labeled oral minimal model to measure hepatic insulin sensitivity (2008)

The ability to accurately quantify indexes of the individual role of glucose (GE(L)) and insulin (S(I)(L)) in the suppression of endogenous glucose production (EGP) would improve the understanding of liver metabolism. Measuring these indexes during an IVGTT by minimal modeling of tracer labeled and unlabeled glucose data is often unreliable, possibly due to an inadequate description of EGP included in the Minimal Model. Moreover, a validation of the assumptions of the Minimal Model on EGP data has never been done. Recently, Krudys et al. (Krudys KM, Dodds MG, Nissen SM, Vicini P. Am J Physiol Endocrinol Metab 288: E1038-E1046, 2005) have proposed a PK/PD (pharmacokinetic/pharmacodynamic) model of the EGP profile that occurs during an intravenous glucose tolerance test (IVGTT); however, this model has also not been validated. The aim of this study was thus to test the Minimal Model, the PK/PD model, and six alternative EGP descriptions on recent model-independent EGP data of 20 subjects obtained with a triple-tracer meal protocol. Model performance was compared in terms of data fit, precision of the estimated parameters, and physiological plausibility. Neither the PK/PD nor the traditional Minimal Model were able to accurately describe EGP data or provide reliable estimates of the indexes. In contrast, one of the new models performed best by showing a good fit and providing accurate and precise estimates of hepatic sensitivity indexes: GE(L) = 0.013 +/- 0.001 dl x kg(-1) x min(-1); S(I)(L) = 5.34 +/- 0.47 10(-4) dl x kg(-1) x min(-1) per microU/ml (42 and 34%, respectively, of total sensitivity indexes GE(TOT) and S(I)(TOT)). Although this model requires further validation, it has the potential to improve our understanding of the role of the liver in pathophysiological states.
Basic Study on Applications of LSTM to State Estimation and Diagnosis in Powertrain Control Systems (2022)

This paper deals with basic application studies of long short-term memory (LSTM) networks to state estimation and diagnosis problems in automotive powertrain control systems. Since an LSTM network can be transformed into a nonlinear state-space equation, it is expected that nonlinear behavior of the powertrain systems can be expressed with it. The LSTM networks are learned with the data generated by an engine simulator built with GT- Power and applied to a diesel engine air path system to estimate turbocharger rotation speed, exhaust manifold pressure, NOx and soot emissions. Moreover, a diagnosis of characteristic variation of the turbocharger is considered based on an LSTM network. Numerical examples demonstrate the effectiveness of the present method.
Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase fromEscherichia coli (2015)

Galactitol-1-phosphate 5-dehydrogenase (GPDH) is a polyol dehydrogenase that belongs to the medium-chain dehydrogenase/reductase (MDR) superfamily. It catalyses the Zn(2+)- and NAD(+)-dependent stereoselective dehydrogenation of L-galactitol 1-phosphate to D-tagatose 6-phosphate. Here, three crystal structures of GPDH from Escherichia coli are reported: that of the open state of GPDH with Zn(2+) in the catalytic site and those of the closed state in complex with the polyols Tris and glycerol, respectively. The closed state of GPDH reveals no bound cofactor, which is at variance with the conformational transition of the prototypical mammalian liver alcohol dehydrogenase. The main intersubunit-contacting interface within the GPDH homodimer presents a large internal cavity that probably facilitates the relative movement between the subunits. The substrate analogue glycerol bound within the active site partially mimics the catalytically relevant backbone of galactitol 1-phosphate. The glycerol binding mode reveals, for the first time in the polyol dehydrogenases, a pentacoordinated zinc ion in complex with a polyol and also a strong hydrogen bond between the primary hydroxyl group and the conserved Glu144, an interaction originally proposed more than thirty years ago that supports a catalytic role for this acidic residue.
A Unified Treatment of Partial Stragglers and Sparse Matrices in Coded Matrix Computation (2021)

The overall execution time of distributed matrix computations is often dominated by slow worker nodes (stragglers) over the clusters. Recently, different coding techniques have been utilized to mitigate the effect of stragglers where worker nodes are assigned the task of processing encoded submatrices of the original matrices. In many machine learning or optimization problems the relevant matrices are often sparse. Several coded computation methods operate with dense linear combinations of the original submatrices; this can significantly increase the worker node computation times and consequently the overall job execution time. Moreover, several existing techniques treat the stragglers as failures (erasures) and discard their computations. In this work, we present a coding approach which operates with limited encoding of the original submatrices and utilizes the partial computations done by the slower workers. Our scheme continues to have the optimal threshold of prior work. Extensive numerical experiments done in AWS (Amazon Web Services) cluster confirm that the proposed approach enhances the speed of the worker computations (and thus the whole process) significantly.
Congenital Adrenal Hyperplasia: Molecular Genetics and Alternative Approaches to Treatment (1999)

Several autosomal recessive disorders affecting the adrenal cortex and its development and leading to defective cortisol biosynthesis are known under the collective term "congenital adrenal hyperplasia" (CAH). Over the last two decades, the genes causing most of these disorders have been identified and molecular genetics may supplement their clinical and biochemical diagnosis. In addition, new treatments have emerged; although gene therapy has yet to be applied in humans, studies are ongoing in gene transfer in adrenocortical cell lines and animal models. In this review, after a brief introduction on the developmental biology and biochemistry of the adrenal cortex and its enzymes, we will list the new developments in the genetics and treatment of diseases causing CAH, starting with the most recent findings. This order happens to follow adrenal steroidogenesis from the mitochondrial entry of cholesterol to cortisol synthesis; it is unlike other presentations of CAH syndromes that start with the most frequently seen syndromes, because the latter were also the first to be investigated at the genetic level and have been extensively reviewed elsewhere. We will start with the latest syndrome to be molecularly investigated, congenital lipoid adrenal hyperplasia (CLAH), which is caused by mutations in the gene coding for the steroidogenic acute regulatory (StAR) protein. We will then present new developments in the genetics of 3-beta-hydroxysteroid dehydrogenase (3 beta HSD), 17 hydroxylase and 17,20-lyase (P450c17), 11 hydroxylase (P450c11 beta), and 21 hydroxylase (P450c21) deficiencies. Alternative treatment approaches and gene therapy experiments are reviewed collectively in the last section, because they are still in their infantile stages.
ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord (1995)

Calcium signaling within astrocytes in the CNS may play a role comparable to that of electrical signaling within neurons. ATP is a molecule known to produce Ca2+ responses in astrocytes, and has been implicated as a mediator of intercellular Ca2+ signaling in other types of nonexcitable cells. We characterized the signal transduction pathway for ATP-evoked Ca2+ responses in cultured astrocytes from the dorsal spinal cord. Nearly 100% of these astrocytes respond to extracellularly applied ATP, which causes release of Ca2+ from an intracellular pool that is sensitive to thapsigargin and insensitive to caffeine. We found that intracellular administration of IP3 also caused release of Ca2+ from a thapsigargin-sensitive intracellular pool, and that IP3 abolished the response to ATP. The ATP-evoked Ca2+ response was blocked by the IP3 receptor antagonist heparin, applied intracellularly, but not by N-desulfated heparin, which is not an antagonist at these receptors. The Ca2+ response caused by ATP was also blocked by a phospholipase C inhibitor, U-73122, but not by its inactive analog, U-73343. Increases in [Ca2+]i were elicited by intracellular application of activators of heterotrimeric G-proteins, GTP gamma S and AIF4-. On the other hand, [Ca2+], was unaffected by a G-protein inhibitor, GDP beta S, but it did abolish the Ca2+ response to ATP. Pretreating the cultures with pertussis toxin did not affect responses to ATP. Our results indicate that in astrocytes ATP-evoked release of intracellular Ca2+ is mediated by IP3 produced as a result of activating phospholipase C coupled to ATP receptors via a G-protein that is insensitive to pertussis toxin. ATP is known to be released under physiological and pathological circumstances, and therefore signaling via the PLC-IP3 pathway in astrocytes is a potentially important mechanism by which ATP may play a role in CNS function.
Transition from a Botanical to a Molecular Classification in Tree Pollen Allergy: Implications for Diagnosis and Therapy (2004)

Tree pollens are among the most important allergen sources. Allergic cross-reactivity to pollens of trees from various plant orders has so far been classified according to botanical relationships. In this context, cross-reactivities to pollens of trees of the Fagales order (birch, alder, hazel, hornbeam, oak, chestnut), fruits and vegetables, between pollens of the Scrophulariales (olive, ash, plantain, privet, lilac) and pollens of the Coniferales (cedar, cypress, pine) are well established. The application of molecular biology methods for allergen characterization has revealed the molecular nature of many important tree pollen allergens. We review the spectrum of tree pollen allergens and propose a classification of tree pollen and related allergies based on major allergen molecules instead of botanical relationships among the allergenic sources. This molecular classification suggests the major birch pollen allergen, Bet v 1 as a marker for Fagales pollen and related plant food allergies, the major olive pollen allergen, Ole e 1, as a possible marker for Scrophulariales pollen allergy and the cedar allergens, Cry j 1 and Cry j 2, as potential markers for allergy to Coniferales pollens. We exemplify for Fagales pollen allergy and Bet v 1 that major marker allergens are diagnostic tools to determine the disease-eliciting allergen source. Information obtained by diagnostic testing with marker allergens will be important for the appropriate selection of patients for allergen-specific forms of therapy.
Państwo i Społeczeństwo nr 4, 2008 : Neopogaństwo w Polsce (2008)

Niniejszy numer „Państwa i Społeczeństwa” podsumowuje dorobek konferencji „Neopogaństwo w Polsce”. Miała ona być próbą naukowego oglądu zjawiska, wobec którego jest wiele przeinaczeń, by nie powiedzieć przekłamań, a które winniśmy poznać, choćby tylko z uwagi na kwestię, tak modną i tak politycznie poprawną w zjednoczonej Europie, jak zapoznawanie się i badanie różnego rodzaju mniejszości. Jest to dobry pierwszy krok. Do tej pory koncentrowano się wyłącznie na mniejszościach narodowych i seksualnych. Teraz nadszedł czas na religijne, tym bardziej, że bardzo wielu chciałoby łączyć je z nacjonalizmem czy nawet faszyzmem i antysemityzmem.
Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study (2017)

A series of acylguanidine beta secretase 1 (BACE1) inhibitors with modified scaffold and P3 pocket substituent was synthesized and studied with free energy perturbation (FEP) calculations. The resulting molecules showed potencies in enzymatic BACE1 inhibition assays up to 1 nM. The correlation between the predicted activity from the FEP calculations and the experimental activity was good for the P3 pocket substituents. The average mean unsigned error (MUE) between prediction and experiment was 0.68 ± 0.17 kcal/mol for the default 5 ns lambda window simulation time improving to 0.35 ± 0.13 kcal/mol for 40 ns. FEP calculations for the P2' pocket substituents on the same acylguanidine scaffold also showed good agreement with experiment and the results remained stable with repeated simulations and increased simulation time. It proved more difficult to use FEP calculations to study the scaffold modification from increasing 5 to 6 and 7 membered-rings. Although prediction and experiment were in agreement for short 2 ns simulations, as the simulation time increased the results diverged. This was improved by the use of a newly developed "Core Hopping FEP+" approach, which also showed improved stability in repeat calculations. The origins of these differences along with the value of repeat and longer simulation times are discussed. This work provides a further example of the use of FEP as a computational tool for molecular design.
Software based object tracking with visual feature integration (1999)

Multiple visual features can be used to track objects in environments where the use of a single visual feature is not sufficient. We have proposed an alternative method to feature integration by way of feature substitution where the dominant feature at any instant is used for tracking. The problem of increased computational cost resulting from the use of multiple features is addressed by using software optimization techniques. Here we use software threads and special instructions provided in MMX processors to increase the frame rate. Experimental results indicate that it is not always necessary to adopt a hardware based approach for real time object tracking even when the computational cost is high.
Microstructural effects on the performance of poly(thiophene) field-effect transistors (2006)

The performance of polymer field-effect transistors is highly dependent on their processing history. For instance, thermal processing plays a role in micro-structure development and consequently in device performance. A transport model was developed based on the semiconductor micro-structure where highly mobile states are located in the crystalline areas and defects and disordered regions correspond to areas where carriers are trapped. By applying this model to electrical characterization data of PQT-12 (a regio-regular polythiophene), it is found that annealing tightens the energetic distribution of the traps. Films quenched from the melt performed worse than annealed films due to an increased trap density and broader energy distribution of the traps. X-ray diffraction in grazing and specular geometry was carried out at the Stanford Synchrotron Radiation Laboratory on PQT-12 thin films to reconcile the predictions of the transport model with the micro-structure of the PQT-12 thin films. In all cases the polymer crystallites are textured with the π-stacking direction in the plane of charge transport and the rocking curves indicate the existence of a population of highly oriented crystallites. Annealing the as-spun films improves the crystallinity and texture, in agreement with the transport model. Quenching produces defects in the films, which are likely to produce traps, thereby lowering the carrier mobility.
An Investigation Study on Mode Mixing Separation in Empirical Mode Decomposition (2019)

Mode mixing is a limitation of the empirical mode decomposition (EMD) method appropriate for physiological signal analysis. In 2008, boundary condition map presented by Rilling and Flandrin provided the efficiency of separating the two components of a two-tone signal as a function of their amplitude and frequency ratios. Until 2019, their findings were still applied. However, their maps only give an uncertainty-like efficiency of mode mixing separation for two-tone signals. In this paper, we propose a criterion for mode mixing separation in EMD, which provides a binary judgment on mode mixing separation instead of the above-mentioned efficiency. By comparing the slopes of the two components, we found that the phenomenon of mode mixing occurs as the extrema of the high-tone component are suppressed by the low-tone component. Under this condition, the criterion shows the relation among their amplitude ratio, frequency ratio, and relative phase between the two components. Given with the values of the three parameters, one can affirm whether the two components are mixed according to the criterion. Accordingly, we derive a black/white three-dimensional (3D) map that plots the binary result of mode mixing in black or white as a function of the three parameters. Our map agrees with Rilling's map and the results obtained from our gait analysis. Among the 23 sets of center-of-mass trajectory signals, six sets encountered the mode mixing problem and their coordinates of the three parameters were found in the black region of the map, while the other 17 sets were in the white region.
6F-5 Characterization of Fabrication Related Gap-Height Variations in Capacitive Micromachined Ultrasonic Transducers (2007)

The gap-height directly affects the static operation point of the CMUT which in turn affects the receive sensitivity and the total possible output pressure. In this paper we report on the characterization of fabrication related gap-height variations in CMUTs. The CMUTs under investigation using the sacrificial release process were found to have lower collapse voltage, smaller maximal membrane deflection and missing pull-in behavior as compared to theory. The in-cavity deposition was examined by SEM and the surface topography on the bottom side of the gap by AFM. The AFM measurements were evaluated for devices with and without in-cavity-deposition as well as devices fabricated with doped polysilicon film or doped bulk silicon for the bottom electrode. A methodology to determine the contribution of each layer in the fabrication process to surface roughness is presented. Our results show that surface roughness reduces the actual gap-height, and the polysilicon layer is the main contributor.
Comparative analysis of void-containing and all-semiconductor 1.5 µm InP-based photonic crystal surface-emitting laser diodes (2021)

This paper analyzes 2D photonic crystal surface-emitting laser diodes with void-containing and all-semiconductor structures by comparing their simulated mode distribution, band structure, and coupling coefficients. A photonic crystal design with a square lattice and circle atoms is considered.