gebhart/patrepeval huggingface dataset:
trans‐Pd(OAc)2(Cy2NH)2 Catalyzed Suzuki Coupling Reactions and Its Temperature‐Dependent Activities Toward Aryl Bromides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Density-of-States Monte Carlo Simulation of a Binary Glass (2004)

A newly proposed Monte Carlo formalism has been used to simulate a glass-forming liquid above and below the glass transition temperature. The heat capacity exhibits a sharp peak at a temperature lower than that reported from extensive molecular dynamics simulations. Its height is larger than that reported earlier. At temperatures below mode coupling, the average inherent-structure energy of the configurations generated in this work is significantly lower than that reported in the literature. The entropy of the supercooled liquid is calculated directly from our simulations and that of a disordered solid is calculated by a normal-mode analysis. We find that at low temperatures these two entropy curves become essentially parallel. They do not intersect each other, raising questions about the existence of a Kauzmann temperature in this glass-forming mixture.
A case report of unexpected right-to-left shunt under mechanical support for post-infarction ventricular septal defect: evaluation with haemodynamic simulator (2021)

ECPELLA (ECMO + Impella) can offset the adverse effects of isolated ECMO support and reduce the PIVSD shunt flow. However, the risk of right-to-left shunt has not been reported, and ECPELLA caused a right-to-left shunt with deoxygenated systemic perfusion in the present case. A simulation study indicated that the right ventricular failure in PIVSD may pose a risk for right-to-left PIVSD shunt under Impella support.
[Tropical biological diversity and therapeutic innovations. Research conducted by ORSTOM]. (1993)

Les organismes vivants elaborent des molecules dont la complexite depasse l'imagination des chimistes. Leurs complexites chimiques vont de pair avec leurs remarquables proprietes biologiques. Les forets tropicales sont avec les recifs coralliens parmi les biomes les plus riches en nombre d'especes et constituent un gisement encore peu explore de nouvelles molecules. En Nouvelle-Caledonie, l'ORSTOM dispose de moyens oceanographiques indispensables pour l'etude et la recolte des Organismes Marins vivant dans le plus grand lagon du monde. De nombreux organismes marins ont ete etudies dans le cadre du programme SMIB (ORSTOM-CNRS) a Noumea. Les extraits de ces organismes sont soumis a un large criblage biologique. Certains des composes isoles, comme la girolline, en sont au stade des essais cliniques
Thermally-Compensated Optical Fiber Silicon Sensor Platform (2021)

This paper describes the characterization and testing of a temperature-compensated optical fiber platform for silicon sensors. Our sensor platform consists of standard optical fiber hardware for optically-balanced and wavelength-multiplexed reflection measurements. We show that thermal effects in silicon sensors are significant for operational temperatures from 275-315 K but can be compensated using a collocated nano-fabricated temperature sensor. Our silicon temperature sensor is a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$150~\mu \text{m}$ </tex-math></inline-formula> wide and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$5~\mu \text{m}$ </tex-math></inline-formula> thick disk that is fabricated on the wafer-scale with a 3 mK/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sqrt {Hz}$ </tex-math></inline-formula> resolution and a 1.7 s thermal time constant in air. Our temperature-compensated platform has sufficient sensitivity and bandwidth to reduce thermal signals in silicon pressure sensors and microphones by more than an order of magnitude.
Focusing light in biological tissue through a multimode optical fiber: refractive index matching (2019)

Controlling light propagation through a step-index multimode optical fiber (MMF) has several important applications, including biological imaging. However, little consideration has been given to the coupling of fiber and tissue optics. In this Letter, we characterized the effects of tissue-induced light distortions, in particular those arising from a mismatch in the refractive index of the pre-imaging calibration and biological media. By performing the calibration in a medium matching the refractive index of the brain, optimal focusing ability was achieved, as well as a gain in focus uniformity within the field-of-view. These changes in illumination resulted in a 30% improvement in spatial resolution and intensity in fluorescence images of beads and live brain tissue. Beyond refractive index matching, our results demonstrate that sample-induced aberrations can severely deteriorate images from MMF-based systems.
Optimizing Green Energy Utilization for Mobile Networks with Hybrid Energy Supplies (2017)

This chapter presents green energy optimization (GEO) schemes, which optimize energy utilization in cellular networks with hybrid energy supplies. The GEO scheme decomposes the problem into two sub-problems: the multi-stage energy allocation problem and the multi-BSs energy balancing problem. The chapter proposes algorithms to solve these sub-problems, and hence solve the green energy optimization problem. It introduces and investigates the green energy provisioning (GEP) problem, which aims to minimize the CAPEX of deploying green energy systems in BSs while satisfying the QoS requirements of cellular networks. The GEP problem is decomposed into the weighted energy minimization problem and the green energy system sizing problem. The chapter proposes a green energy provisioning solution consisting of a provision-cost aware traffic load balancing algorithm and a binary energy system sizing algorithm to solve the sub-problems and hence solve the GEP problem.
Knowledge-Grounded Conversational Data Augmentation with Generative Conversational Networks (2022)

While rich, open-domain textual data are generally available and may include interesting phenomena (humor, sarcasm, empathy, etc.) most are designed for language processing tasks, and are usually in a non-conversational format. In this work, we take a step towards automatically generating conversational data using Generative Conversational Networks, aiming to benefit from the breadth of available language and knowledge data, and train open domain social conversational agents. We evaluate our approach on conversations with and without knowledge on the Topical Chat dataset using automatic metrics and human evaluators. Our results show that for conversations without knowledge grounding, GCN can generalize from the seed data, producing novel conversations that are less relevant but more engaging and for knowledge-grounded conversations, it can produce more knowledge-focused, fluent, and engaging conversations. Specifically, we show that for open-domain conversations with 10\% of seed data, our approach performs close to the baseline that uses 100% of the data, while for knowledge-grounded conversations, it achieves the same using only 1% of the data, on human ratings of engagingness, fluency, and relevance.
Abstract TMP35: Optogenetic Stimulation Of Motor Cortex Neurons Promotes Recovery After Stroke (2013)

Objective: Functional recovery after stroke has been observed in both animal and human studies and is currently attributed to both brain remodeling and plasticity. Brain stimulation techniques such as electrical stimulation and transcranial magnetic stimulation have been used successfully to enhance recovery. However, what mediates this recovery is not well understood. Elucidating the mechanism(s) is difficult because these stimulation techniques non-specifically activate all cell types near the stimulation site. Here we use optogenetic techniques to specifically stimulate layer V pyramidal neurons in the ipsilesional motor cortex at day 5 post-stroke, and investigate the effects on functional recovery as well as underlying mechanisms. Methods: Thy-1-ChR2-YFP line-18 transgenic male mice were used. Mice underwent stereotaxic surgery to implant a fiber cannula in the ipsilesional M1. All mice were then subjected to an intraluminal middle cerebral artery suture occlusion (30min). Optogenetic stimulation began at day 5 post-stroke and continued until day 14 post-stroke. Sensorimotor behavior tests were used to assess their behavioral recovery at day 0, 2, 7, 10 and 14 post-stroke. Body weights were also measured. Changes in cerebral blood flow were measured at day 14 post-stroke using the Laser Doppler Flowmetry. Results: Rotating beam test revealed that stimulated mice recovered significantly faster than non-stimulated control mice at day 10 and 14 after stroke (p&lt;0.05). Stimulated mice also performed significantly better in the adhesive tape test at day 14, with a shorter tape removal time on the contralesional limb (p&lt;0.05). Additionally, a significantly faster regain of body weight was observed in stimulated mice after stroke (p&lt;0.05-0.01). Cerebral blood flow measurements revealed that stimulated mice exhibited significantly larger increase in cerebral blood flow at day 14 post-stroke (p&lt;0.05-0.01). Conclusion: These data indicate that optogenetic stimulation of motor cortex neurons can promote behavioral recovery in mice after stroke. Current studies examine the mechanisms underlying this recovery, including genes related to neurovascular coupling and neurotrophic factors after stimulation.
Enabling Driving Cycle Loss Reduction in Variable Flux PMSMs Via Closed-Loop Magnetization State Control (2018)

Variable flux permanent magnet synchronous machines (VF-PMSMs) have recently been proposed to reduce driving cycle losses in electric vehicle traction motors via magnetization state (MS) manipulation. This paper presents a closed-loop MS control method to enable reliable loss minimization control of VF-PMSMs. The MS is estimated at every sample instant and is used as a feedback for closed-loop control. Under most circumstances, the proposed method maintains precise torque control even during the MS manipulation transient by using a deadbeat-direct torque and flux control (DB-DTFC) framework. The state-of-the-art high-speed flux trajectory generation method for MS manipulation is integrated in the new closed-loop method to allow MS manipulation up to the maximum speed within the inverter voltage limit. The effectiveness of the proposed methods, in terms of driving cycle loss reduction capability and its thermal impact, is evaluated experimentally by emulating the road load using the dynamometer load motor.
A filter model to analyze reconstruction artifacts in perfusion C-arm CT (2010)

Interventional perfusion imaging with a C-arm angiography system capable of 3-D imaging (C-arm CT) could optimize the clinical workflow during stroke treatment. Acquisition times are currently of the order of several seconds per short-scan and filtered backprojection reconstruction artifacts can arise due to the time-dependence of the attenuation values. In this paper, we present a novel formalism to model reconstruction artifacts by a spatio-temporal filter in the object domain. The filter consists of terms that depend on the temporal derivatives of the attenuation values. Using this model, artifacts due to time-dependent attenuation values can be well explained and studied. We apply the filter model to analyze redundancy weighting schemes in order to reduce these artifacts. Furthermore, this model could be the basis to develop new dynamic reconstruction algorithms.
A Mask Reuse Methodology for Reducing System-on-a-Chip Cost (2005)

Today's system-on-a-chip (SoC) design methodology provides an efficient way to develop highly integrated systems on a single chip by utilizing pre-designed intellectual property (IP) or "cores". However, once assembled, the physical design and manufacturing process that follows does not benefit from the reuse of these cores. We propose an alternative mask reuse methodology (MRM) where most cores are provided with hardened layouts, significantly reducing the number of components for chip-level processing and the associated turn-around time. In addition, each core has a pre-verified mask set, which can be re-used to significantly reduce the overall mask cost and mask manufacturing time. Since mask cost and design and verification times are rapidly becoming prohibitive for low or even medium volume ASIC parts, the proposed MRM methodology can help reduce the barrier for ASIC parts. We provide details of the methodology, as well as an assessment of its impact on design time and design cost with an example of a network processor SoC.
Thermal Resistance of Particle Laden Polymeric Thermal Interface Materials (2003)

Abstract Particle laden polymers are one of the most prominent thermal interface materials (TIM) used in electronics cooling. Most of the research has primarily dealt with the understanding of the thermal conductivity of these types of TIMs. For thermal design, reduction of the thermal resistance is the end goal. Thermal resistance is not only dependent on the thermal conductivity, but also on the bond line thickness (BLT) of these TIMs. It is not clear which material property(s) of these particle laden TIMs affects the BLT and eventually the thermal resistance. This paper introduces a rheology based semiempirical model for the prediction of the BLT of these TIMs. BLT depends on the yield stress of the particle laden polymer and the applied pressure. The BLT model combined with the thermal conductivity model can be used for modeling the thermal resistance of these TIMs for factors such as particle volume faction, particle shape, base polymer viscosity, etc. This paper shows that there exists an optimal filler volume fraction at which thermal resistance is minimum. Finally this paper develops design rules for the optimization of thermal resistance for particle laden TIMs.
Temperature-Sensitive Mutants of Mycoplasma pneumoniae: I. In Vitro Biologic Properties (1969)

Journal Article Temperature-Sensitive Mutants of Mycoplasma pneumoniae: I. In Vitro Biologic Properties Get access Paul Steinberg, Paul Steinberg From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert L. Horswood, Robert L. Horswood From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert M. Chanock Robert M. Chanock From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 120, Issue 2, August 1969, Pages 217–224, https://doi.org/10.1093/infdis/120.2.217 Published: 01 August 1969 Article history Received: 12 February 1969 Published: 01 August 1969
Horizontal Permeability Anisotropy Characterization by Pressure Transient Testing and Geological Data (1992)

Abstract The anisotropy of horizontal permeability plays an important role in fluid flow distributions in reservoirs. However, it is rarely detected in the early stage of a reservoir study. Water break-through during production is usually the first evidence of such anisotropy. A technique to investigate the horizontal permeability has been developed, based on pressure transient analysis and geological data. Anisotropy has been detected and quantified using a pressure transient analysis and a knowledge of the reservoir geometry derived from geological analysis. The results obtained are subsequently confirmed by petrophysical measurements on oriented cores. The use of these results has been of primary importance in matching the pressure history of the "full-field" numerical simulation. The origin of the anisotropy was identified by a sedimentological study, based on core analysis and FMS interpretation. The anisotropy is related to the internal structure of the sandbodies (foresets), which were deposited in a shore-face environment. The azimuth of the paleo-coastline corresponds to the direction of the maximum value of permeability derived from the well-test analysis and the core measurements.
Secretory expression and characterization of insulin in Pichia pastoris (1999)

The yeasts Pichia pastoris and Saccharomyces cerevisiae have similar overall features regarding the secretory expression of insulin. The S. cerevisiae mating factor alpha (alpha-factor) prepro-leader facilitated the secretion of an insulin precursor, but not proinsulin expressed in P. pastoris. Synthetic prepro-leaders developed for the secretory expression of the insulin precursor in S. cerevisiae also facilitated the secretion of the insulin precursor expressed in P. pastoris. In contrast with S. cerevisiae, only insulin precursor and no unprocessed hyperglycosylated alpha-factor pro-leader/insulin precursor fusion protein was secreted from P. pastoris. A spacer peptide in the fusion protein increased the fermentation yield of the insulin precursor in P. pastoris. A synthetic prepro-leader, but not an alpha-factor prepro-leader lacking N-glycosylation sites, facilitated the secretion of the insulin precursor in P. pastoris. P. pastoris has a capacity for secretory expression of the insulin precursor that is equal to or better than that of S. cerevisiae. Peptide mapping and MS indicated a structure of the insulin precursor expressed in P. pastoris identical with that of human insulin.
They Said What? (2015)

In online communities, satisfied members are essential to community success, since they are more likely to contribute and consume content, engage with other members, and feel committed to the community. However, it is difficult for community leaders to know, on an on-going basis, whether members are satisfied. In this paper, we explore the relationship between member satisfaction and language use within content posted in workplace online communities. We hope to find patterns of language use that are associated with satisfied members. We employ linguistic analysis based on LIWC, and a survey to directly measure member satisfaction in 142 workplace communities. We contribute a better understanding of how members interact in effective workplace communities, and show that linguistic analysis could be a useful part of future methods to automatically assess community member satisfaction.
Upper Respiratory Infection Drives Clinical Signs and Inflammatory Responses Following Heterologous Challenge of SARS-CoV-2 Variants of Concern in K18 Mice (2023)

The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of several variants of concern (VOC) with increased immune evasion and transmissibility. This has motivated studies to assess protection conferred by earlier strains following infection or vaccination to each new VOC. We hypothesized that while NAbs play a major role in protection against infection and disease, a heterologous reinfection or challenge may gain a foothold in the upper respiratory tract (URT) and result in a self-limited viral infection accompanied by an inflammatory response. To test this hypothesis, we infected K18-hACE2 mice with SARS-CoV-2 USA-WA1/2020 (WA1) and, after 24 days, challenged with WA1, Alpha, or Delta. While NAb titers against each virus were similar across all cohorts prior to challenge, the mice challenged with Alpha and Delta showed weight loss and upregulation of proinflammatory cytokines in the URT and lower RT (LRT). Mice challenged with WA1 showed complete protection. We noted increased levels of viral RNA transcripts only in the URT of mice challenged with Alpha and Delta. In conclusion, our results suggested self-limiting breakthrough infections of Alpha or Delta in the URT, which correlated with clinical signs and a significant inflammatory response in mice.
Design of Cationic Conjugated Polyelectrolytes for DNA Concentration Determination (2007)

Cationic conjugated polyelectrolytes poly110 and poly120 were designed, synthesized, and characterized with the anticipation of function in the determination of double-stranded DNA concentration [dsDNA]. Their structures contain a pi-delocalized optically active backbone composed of phenylene-fluorene segments copolymerized with 2,1,3-benzothiadiazole (BT) units and charged pendant groups that allow excellent solubility in water. The subscript in poly1x refers to the molar percent of BT units in the chain. Addition of dsDNA to poly110 or poly120 results in a change in the color of emission from blue to green. These spectral changes can be treated to obtain the parameter delta, which can be used to generate calibration curves that indicate [dsDNA]. Analysis of photoluminescence spectra reveals that dsDNA addition gives rise to more efficient FRET from blue emitting segments to the BT sites, an increase in the BT emission quantum yield, and partial quenching of the phenylene-fluorene segments. Studies were also carried out to maximize the range of [dsDNA] determination. We find that by combining the response from two different initial concentrations of poly110, it is possible to generate calibration curves that respond with a difference in [dsDNA] of over 7 orders of magnitude.
DENSITY DISTRIBUTION ANALYSIS OF THE E2-TYPE GLENOID (2020)

This study examined the regional variations of cortical and cancellous bone density present in superiorly eroded glenoids. It is hypothesized that eroded regions will contain denser bone in respons...
Coherent Two-Octave-Spanning Supercontinuum Generation in Lithium-Niobate Waveguides (2019)

We demonstrate a coherent supercontinuum spanning two octaves with 35 pJ pulses in a lithium-niobate waveguide under the presence of second-and third-order nonlinear effects, which allows for detection of the carrier-envelope offset frequency on-chip. © 2019 The Author(s)
A directional deblocking filter based on intra prediction for H.264/AVC (2009)

Although the adaptive deblocking filter of H.264/AVC efficiently reduces blocking artifacts for most images, it is limited in removing the blocking artifacts of the directional edge on the block boundaries. In order to solve this problem, we propose a directional deblocking filter based on intra prediction direction. The proposed algorithm performs directional filtering according to the direction of the intra prediction mode in order to correctly find the block edge while avoiding computational burden. Experimental results show that the proposed algorithm provides subjective improvements at the directional edge and PSNR gain of up to 0.13dB.
Modification of transparent and conducting single wall carbon nanotube thin films via bromine functionalization (2007)

The results of bromine doping of transparent and conducting single wall carbon nanotube (SWNT) thin films are described. Br profoundly effects the density of states (DOS) of SWNTs which leads to dramatic improvement in the electrical properties. The authors show that the role of the Br is not only in shifting the Fermi level but also in forming acceptor sites in metallic SWNTs. These modifications of the DOS through bromination lead to simultaneous increase in both the on/off ratio and mobility of thin film transistors. Furthermore, the transistor characteristics of Br-functionalized SWNTs are similar in air, inert atmosphere, and vacuum.