gebhart/patrepeval huggingface dataset:
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets (2015)

Our findings support current models and experimental studies of the brainstem saccade-generating neurons and indicate that damage to PN may permanently impair the function of these neurons that the PN ensheathe. How a postulated hypoxic mechanism could selectively damage the PN remains unclear. We propose that the well-studied saccadic eye movement system provides an accessible model to evaluate the role of PN in health and disease.
Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes (2015)

Carnosol showed potent inhibition of pro-inflammatory and catabolic mediators of cartilage breakdown in chondrocytes. Inhibition of matrix degradation and enhancement of formation was observed in chondrocytes cocultured with subchondral osteoblasts preincubated with carnosol indicating a cross-talk between these two cellular compartments, potentially mediated via inhibition of IL-6 in osteoblasts as similar results were obtained with anti-IL-6 antibody.
Single-particle trajectories reveal two-state diffusion-kinetics of hOGG1 proteins on DNA (2018)

We reanalyze trajectories of hOGG1 repair proteins diffusing on DNA. A previous analysis of these trajectories with the popular mean-squared-displacement approach revealed only simple diffusion. Here, a new optimal estimator of diffusion coefficients reveals two-state kinetics of the protein. A simple, solvable model, in which the protein randomly switches between a loosely bound, highly mobile state and a tightly bound, less mobile state is the simplest possible dynamic model consistent with the data. It yields accurate estimates of hOGG1's (i) diffusivity in each state, uncorrupted by experimental errors arising from shot noise, motion blur and thermal fluctuations of the DNA; (ii) rates of switching between states and (iii) rate of detachment from the DNA. The protein spends roughly equal time in each state. It detaches only from the loosely bound state, with a rate that depends on pH and the salt concentration in solution, while its rates for switching between states are insensitive to both. The diffusivity in the loosely bound state depends primarily on pH and is three to ten times higher than in the tightly bound state. We propose and discuss some new experiments that take full advantage of the new tools of analysis presented here.
Supplementary Table 5 from MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias (2023)

&lt;p&gt;PDF file - 471K&lt;/p&gt;
α‐Phenyl‐N‐tert‐butylnitrone‐Type Derivatives Bound to β‐Cyclodextrins: Syntheses, Thermokinetics of Self‐Inclusion and Application to Superoxide Spin‐Trapping (2007)

alpha-Phenyl-N-tert-butylnitrone (PBN) derivatives bound to beta-cyclodextrin derivatives have been synthesized. Inclusion of the PBN group into the beta-cyclodextrin moiety is host- and temperature-dependent. In the case of the nitrone linked to permethylated cyclodextrin (Me3CD-PBN), the thermokinetic parameters are in favour of a slow chemical exchange between a tight and a loose complex. In contrast, 2,6-di-O-Me-beta-cyclodextrin-grafted PBN (Me2CD-PBN) exists either in a fast exchange or as a strongly self-associated complex. The covalent cyclodextrin-PBN compounds have been used to trap carbon and oxygen-centred free radicals. The self-associated forms of the beta-CD-spin-traps are compatible with effective spin-trapping, affording spin-adducts with enhanced EPR signal intensities relative to noncovalent CD-nitrone systems or the nitrone alone. This kind of cyclodextrin-bound nitrone is the first type of covalent supramolecular spin-trap and should open new possibilities for the study of biological free radicals in vivo.
Optical pumped InGaAs/GaAs nano-ridge laser epitaxially grown on a standard 300-mm Si wafer (2017)

Fully exploiting the potential of silicon photonics requires high-performance active devices such as lasers, which can be monolithically integrated in a scalable way.However, direct bandgap III-V semiconductors exhibit a large lattice mismatch and/or strongly differing thermal expansion coefficient with silicon.This makes monolithic integration on silicon without introducing excessive defects in the material extremely difficult.The majority of the methods proposed thus far either are not compatible with further low-cost integration or rely on a special substrate.Here we demonstrate monolithic InGaAs/GaAs single-mode nano-ridge lasers directly grown on a standard (001) 300-mm Si wafer.Exploiting the aspect ratio defect trapping technique, unwanted defects are confined to a narrow trench defined in the silicon substrate.The nano-ridge structures subsequently grown out of these trenches are of high crystalline quality as shown by high-resolution transmission electron microscopy analysis and a strong photoluminescence response.They can be controlled in shape by optimizing the growth conditions, which allows us to minimize substrate leakage and maximize confinement in the InGaAs quantum wells providing optical gain.Distributed feedback lasers were fabricated by defining a first-order grating in the nano-ridge.Under pulsed optical pumping, singlemode lasing with side mode suppression over 28 dB was shown, and precise control of the emission wavelength over 60 nm was achieved.This demonstration proves the high quality of the material and provides a credible road towards a CMOS-compatible platform for high-volume manufacturing of silicon photonic integrated circuits, including laser and amplifier devices.
Self‐Assembly of Simple Corroles, via Hydrogen Bonding and Coordination (2020)

The unique properties of pyrazole raised the interest of preparing a corrole containing one such moiety on its C 10 position. Its single‐crystal X‐ray structure uncovers it to be a dimer wherein the two monomeric units are held together by very strong corrole‐pyrazole NH ··· N hydrogen bonding interactions that lead to a very well self‐assembled network. The corresponding gallium(III) complex is isolated as a trimer in which all hydrogen bonding interactions are between the pyrazole subunits. In contrast, a tetrameric coordination complex is formed from the gallium(III) complex of a corrole with a pyridyl moiety on C 10 .
Asymmetrische Synthese (1999)

Die Herstellung von chiralen Verbindungen ist eine der wichtigsten intellektuellen Herausforderungen der Organischen Synthese, nicht nur im Bereich der pharmazeutischen Industrie, geworden. Wie zuvor erwähnt (Kapitel 14), sind biologische Systeme sehr empfindlich gegenüber den chiralen Verbindungen, mit denen sie wechselwirken. Daher sind praktische Methoden zur Erzeugung nur eines Stereoisomers aufgrund der höheren Ausbeute, geringeren Abfallmenge und leichteren Reinigung von großem Wert. Die Synthese eines chiralen Medikamentes in seiner racemischen Form ist nicht effektiv, wenn nur ein Enantiomer aktiv ist, da dann 50% des Endprodukts nutzlos sind und eine weitere Behandlung, z.B. eine Trennung, wenn möglich ein Recycling oder eine Beseitigung, notwendig ist.
IR study of acrolein hydrogenation over Co/SiO2catalysts (1997)

Gas-phase and surface spectra are reported for Co/SiO2 exposed at 295 and 373 K, with and without hydrogen, to acrolein, propanal, allyl alcohol and propan-1-ol. Adsorbed species on silica, Coo and oxidised Co sites with accompanying oxide ions are discussed in relation to the hydrogenation reactions of acrolein. The dominant reaction involved propan-1-ol formation via propanal. Providing that Coo sites were present to dissociate hydrogen, hydrogenation of alkenyl groups in adsorbed species on silica or oxidised cobalt sites readily occurred but did not necessarily constitute a mechanism for product formation.
Label-Free Morphology-Based Prediction of Multiple Differentiation Potentials of Human Mesenchymal Stem Cells for Early Evaluation of Intact Cells (2014)

Precise quantification of cellular potential of stem cells, such as human bone marrow-derived mesenchymal stem cells (hBMSCs), is important for achieving stable and effective outcomes in clinical stem cell therapy. Here, we report a method for image-based prediction of the multiple differentiation potentials of hBMSCs. This method has four major advantages: (1) the cells used for potential prediction are fully intact, and therefore directly usable for clinical applications; (2) predictions of potentials are generated before differentiation cultures are initiated; (3) prediction of multiple potentials can be provided simultaneously for each sample; and (4) predictions of potentials yield quantitative values that correlate strongly with the experimental data. Our results show that the collapse of hBMSC differentiation potentials, triggered by in vitro expansion, can be quantitatively predicted far in advance by predicting multiple potentials, multi-lineage differentiation potentials (osteogenic, adipogenic, and chondrogenic) and population doubling potential using morphological features apparent during the first 4 days of expansion culture. In order to understand how such morphological features can be effective for advance predictions, we measured gene-expression profiles of the same early undifferentiated cells. Both senescence-related genes (p16 and p21) and cytoskeleton-related genes (PTK2, CD146, and CD49) already correlated to the decrease of potentials at this stage. To objectively compare the performance of morphology and gene expression for such early prediction, we tested a range of models using various combinations of features. Such comparison of predictive performances revealed that morphological features performed better overall than gene-expression profiles, balancing the predictive accuracy with the effort required for model construction. This benchmark list of various prediction models not only identifies the best morphological feature conversion method for objective potential prediction, but should also allow clinicians to choose the most practical morphology-based prediction method for their own purposes.
Merging homogeneous catalysis with biocatalysis; papain as hydrogenation catalyst (2005)

Papain, modified at Cys-25 with a monodentate phosphite ligand and complexed with Rh(COD)2BF4, is an active catalyst in the hydrogenation of methyl 2-acetamidoacrylate.
Information-driven interaction-oriented programming: BSPL, the blindingly simple protocol language (2011)

We present a novel approach to interaction-oriented programming based on declaratively representing communication protocols. Our approach exhibits the following distinguishing features. First, it treats a protocol as an engineering abstraction in its own right. Second, it models a protocol in terms of the information that the protocol needs to proceed (so agents enact it properly) and the information the protocol would produce (when it is enacted). Third, it naturally maps traditional operational constraints to the information needs of protocols, thereby obtaining the desired interactions without additional effort or reasoning. Fourth, our approach naturally supports shared nothing enactments: everything of relevance is included in the communications and no separate global state need be maintained. Fifth, our approach accommodates, but does not require, formal representations of the meanings of the protocols. We evaluate this approach via examples from the literature.
A 47nW, 0.7-3.6V wide Supply Range, Resistor Based Temperature Sensor for IoT Applications (2019)

A sub 1-V, ultra low power temperature sensor has been implemented in TSMC 180 nm. The architecture is digital friendly since it creates a pulse width modulated wave instead of voltage. It uses proportional to absolute temperature(PTAT) characteristics of resistance to generate PTAT delay. Temperature to delay conversion depends only on passive elements, thereby making the circuit insensitive to supply variations. Line sensitivity of 0.23 °C/V is achieved for a wide supply range of 0.7-3.6V. A non linearity error of less than 0.8 °C is measured for -55 to 125 °C using linear fit curve. This occupies an area of 0.82 mm <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and consumes a power of 47 nW at 0.8 V supply.
Eye gaze and text line matching for reading analysis (2015)

Eye tracking data has been widely used to analyze our reading behavior. Usually, experiments are carried out with head fixations or by analyzing eye tracking data in large areas such as paragraphs. But if we want to analyze the eye gaze line by line or word by word with a non invasive apparatus, we have to face the mislocation of the recorded eye gaze. The lack of accuracy involves a difficult analysis of the small eyes movements during reading. This paper proposes a method to match lines of gazes with corresponding text lines, using three different methods. We will show that the Dynamic Time Warping is a promising way to measure similarity between a line of gaze and a text line.
Discrete and Continuous Maxima in Multicarrier Communication (2005)

The ratio between the discrete and continuous maxima of signals used in multicarrier communications is analyzed. An exact expression, up to an additive term, is obtained for the considered ratio when the number of uniformly distributed samples is equal to the number of carriers. A more accurate upper estimate on the continuous maximum from discrete samples of the signal and its derivative is suggested. Finally, a tight upper bound is given for the value of the continuous maximum via discrete values of samples when the number of samples is greater than the number of carriers.
Total evaluation of W-Ti absorber for x-ray mask (1994)

W-Ti film was comprehensively investigated for its application as an x-ray mask absorber. A stress-free and amorphous W-Ti film was successfully deposited by dc sputtering with a W-Ti (1 wt%) target using a gas mixture of Ar and N<SUB>2</SUB>. To obtain much lower stress, we firstly improve the accuracy of stress measurement up to +/- 1 MPa, and ultra-low stress film was obtained by step-annealing. The stress of the film has been found stable enough to apply to x- ray masks in an air atmosphere and for x-ray exposure. The density, composition, and microstructure of the film were also evaluated by SEM, XD, XPS, and TDS. The film surface was very smooth and the roughness measured by AFM was about 2 nm. The etching properties of the absorber using a Cr mask, ITO stopper and electron cyclotron resonance (ECR) discharge plasmas were also investigated in order to achieve a resolution of below 0.1 micrometers . Highly selective and anisotropic etching has been realized using a mixture of SF<SUB>6</SUB> and CHF<SUB>3</SUB>, by cooling the stage to about -50 degree(s)C under controlled plasma conditions. Moreover, the microfabrication of a smooth W-Ti absorber has been demonstrated for lines and spaces patterns of 0.06 micrometers and for 1-Gbit-class dynamic random access memory patterns.
Transcriptional Activation by the Product of Open Reading Frame 50 of Kaposi’s Sarcoma-Associated Herpesvirus Is Required for Lytic Viral Reactivation in B Cells (1999)

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a lymphotropic virus strongly linked to the development of KS, an endothelial cell neoplasm frequent in persons with AIDS. Reactivation from latency in B cells is thought to be an important antecedent to viral spread to endothelial cells during KS pathogenesis. Earlier experiments have posited a role for the transcriptional activator encoded by KSHV open reading frame 50 (ORF50) in such reactivation, since ectopic overexpression of this protein induces reactivation in latently infected B cells. Here we have explored several aspects of the expression, structure, and function of this protein bearing on this role. The ORF50 gene is expressed very early in lytic reactivation, before several other genes implicated as candidate regulatory genes in related viruses, and its expression can upregulate their promoters in transient assays. The protein is extensively phosphorylated in vivo and bears numerous sites for phosphorylation by protein kinase C, activators of which are potent stimulators of lytic induction. The C terminus of the ORF50 protein contains a domain that can strongly activate transcription when targeted to DNA; deletion of this domain generates an allele that expresses a truncated protein which retains the ability to form multimers with full-length ORF50 and functions as a dominant-negative protein. Expression of this allele in latently infected cells ablates spontaneous reactivation from latency and strikingly suppresses viral replication induced by multiple stimuli, including phorbol ester, ionomycin, and sodium butyrate. These results indicate that the ORF50 gene product plays an essential role in KSHV lytic replication and are consistent with its action as a putative molecular switch controlling the induction of virus from latency.
Genetic and functional characterization of a novel meta‐pathway for degradation of naringenin in Herbaspirillum seropedicae SmR1 (2016)

In this study, a random mutant library of Herbaspirillum seropedicae SmR1 was constructed by Tn5 insertion and a mutant incapable of utilizing naringenin as a carbon source was isolated. The Tn5 transposon was found to be inserted in the fdeE gene (Hsero_1007), which encodes a monooxygenase. Two other mutant strains in fdeC (Hsero_1005) and fdeG (Hsero_1009) genes coding for a dioxygenase and a putative cyclase, respectively, were obtained by site-directed mutagenesis and then characterized. Liquid Chromatography coupled to mass spectrometry (LC-MS)/MS analyses of culture supernatant from the fdeE mutant strain revealed that naringenin remained unaltered, suggesting that the FdeE protein is involved in the initial step of naringenin degradation. LC-MS/MS analyses of culture supernatants from the wild-type (SmR1) and FdeC deficient mutant suggested that in H. seropedicae SmR1 naringenin is first mono-oxygenated by the FdeE protein, to produce 5,7,8-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one, that is subsequently dioxygenated and cleaved at the A-ring by the FdeC dioxygenase, since the latter compound accumulated in the fdeC strain. After meta-cleavage of the A-ring, the subsequent metabolic steps generate oxaloacetic acid that is metabolized via the tricarboxylic acid cycle. This bacterium can also modify naringenin by attaching a glycosyl group to the B-ring or a methoxy group to the A-ring, leading to the generation of dead-end products.
Carbenes and the oxygen-hydrogen bond: bicycloalkylidenes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbenes and the oxygen-hydrogen bond: bicycloalkylidenesWolfgang Kirmse, Thomas Meinert, David A. Modarelli, and Matthew S. PlatzCite this: J. Am. Chem. Soc. 1993, 115, 20, 8918–8927Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://doi.org/10.1021/ja00073a005RIGHTS & PERMISSIONSArticle Views1153Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Demand-side load management in smart homes (2012)

Studies have shown that buildings consumer over 75% of the total electricity and over 45% of the total energy usage in many countries. Given rising energy prices and climate change, energy efficiency techniques that reduce the energy and carbon footprint of buildings is an important societal need. In this talk, I will argue that Information and Communication technologies (ICT) are a crucial component for achieving energy efficiency in smart buildings. I will describe demand-side load management techniques where users or intelligent building components take an active role in reducing and optimizing a building's energy footprint and also present present hurdles in achieving energy-efficiency through these methods. Finally, I will describe two of our recent efforts in demand-side load management via peak load shaving. Our first effort focuses on background load scheduling and coordination to transparently reduce peak electricity load without any change in user behavior, while our second technique uses small batteries and any available local renewable sources to shift supply to demand, rather than conventional techniques that adjust demand based on supply.
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features (2000)

The FHIT gene is located at a chromosomal site (3p14.2) which is commonly affected by translocations and deletions in human neoplasia. Although FHIT alterations at the DNA and RNA level are frequent in many types of tumours, the biological and clinical significance of these changes is not clear. In this study we aimed at correlating loss of Fhit protein expression with a large number of molecular genetic and clinical parameters in a well-characterized cohort of non-small-cell lung cancers (NSCLCs). Paraffin sections of 99 non-small-cell carcinomas were reacted with an anti-Fhit polyclonal antibody in a standard immunohistochemical reaction. Abnormal cases were characterized by complete loss of cytoplasmic Fhit staining. The Fhit staining results were then correlated with previously obtained clinical and molecular data. Fifty-two of 99 tumours lacked cytoplasmic Fhit staining, with preserved reactivity in adjacent normal cells. Lack of Fhit staining correlated with: loss of heterozygosity (LOH) at the FHIT 3p14.2 locus, but not at other loci on 3p; squamous histology; LOH at 17p13 and 5q but not with LOH at multiple other suspected tumour suppressor gene loci; and was inversely correlated with codon 12 mutations in K-ras. Fhit expression was not correlated overall with a variety of clinical parameters including survival and was not associated with abnormalities of immunohistochemical expression of p53, RB, and p16. All of these findings are consistent with loss of Fhit protein expression being as frequent an abnormality in lung cancer pathogenesis as are p53 and p16 protein abnormalities and that such loss occurs independently of the commitment to the metastatic state and of most other molecular abnormalities.
<title>Actuation of polysilicon surface-micromachined mirrors</title> (1996)

Two types of polysilicon surface-micromachined actuators designed for moving hinged micromirrors are described. An electrostatic comb-drive actuator comprised of interdigitated capacitors has been used to move a mirror at frequencies of at least a kHz. Impact-actuated linear vibromotors allow mirrors to travel over large (&gt; 100 micrometers ) ranges with submicron positioning.