gebhart/patrepeval huggingface dataset:
Poster: 4th Industrial Revolution: Toward Deterministic Wireless Industrial Networks (2017)

Critical applications such as industrial process control, smart grid and vehicle automation require networks which offer on-time data delivery and wire-like end-to-end reliability. This paper proposes to exploit path diversity to compensate for the lossy nature of the wireless medium. We introduce “Leapfrog Collaboration”, a communication mechanism in which multiple copies of the same packet traverse the network on disjoint paths. Emulation results on Cooja show that, compared to single-path transmission, this technique reduces end-to-end delay by up to 28%, and jitter by up to 58%.
Late fulminant posterior reversible encephalopathy syndrome after liver transplant. (2009)

Posterior reversible encephalopathy syndrome after liver transplant is rare. We recommend a complete cessation of any calcineurin inhibitor rather than a dose reduction.
Spermine Mediates Inward Rectification in Potassium Channels of Turtle Retinal Müller Cells (2001)

Retinal Müller cells are highly permeable to potassium as a consequence of their intrinsic membrane properties. Therefore these cells are able to play an important role in maintaining potassium homeostasis in the vertebrate retina during light-induced neuronal activity. Polyamines and other factors present in Müller cells have the potential to modulate the rectifying properties of potassium channels and alter the Müller cells capacity to siphon potassium from the extracellular space. In this study, the properties of potassium currents in turtle Müller cells were investigated using whole cell voltage-clamp recordings from isolated cells. Overall, the currents were inwardly rectifying. Depolarization elicited an outward current characterized by a fast transient that slowly recovered to a steady level along a double exponential time course. On hyperpolarization the evoked inward current was characterized by an instantaneous onset (or step) followed by a slowly developing sustained inward current. The kinetics of the time-dependent components (block of the transient outward current and slowly developing inward current) were dependent on holding potential and changes in the intracellular levels of magnesium ions and polyamines. In contrast, the instantaneous inward and the sustained outward currents were ohmic in character and remained relatively unaltered with changes in holding potential and concentration of applied spermine (0.5--2 mM). Our data suggest that cellular regulation in vivo of polyamine levels can differentially alter specific aspects of potassium siphoning by Müller cells in the turtle retina by modulating potassium channel function.
Investigation of the impact of the oxide thickness and RESET conditions on disturb in HfO<inf>2</inf>-RRAM integrated in a 65nm CMOS technology (2013)

In this work, a comprehensive investigation of disturb in HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -Resistive Random Access Memories (RRAM) integrated in an advanced 65nm technology is presented. The effects of the oxide thickness and RESET conditions on disturb immunity of the High-Resistance-State (HRS) are explored. Constant Voltage Stress is applied on a large amount of samples at various temperatures. Data are collected and analyzed on a statistical basis. The SET dependence to the RESET conditions is investigated and correlated to the length of the induced depleted gap along the conductive filament. The conduction mechanism of the HRS is correlated to the failure/SET process of the RRAM device through a voltage acceleration model. It is shown that thicker dielectric oxide and stronger RESET conditions give rise to longer failure times.
Empirical Pulmonary Vein Isolation in Patients with Chronic Atrial Fibrillation Using a Three‐Dimensional Nonfluoroscopic Mapping System: Long‐Term Follow‐Up (2001)

The purpose of this study was to assess the feasibility and long-term results of empirical isolation of both superior pulmonary veins in patients with chronic AF. Although localizing and ablating the focal triggers of AF has been proven an effective approach, this strategy is time consuming, often requires multiple procedures, and carries the risk of pulmonary vein stenosis. Whether ostial electrical isolation of the superior pulmonary veins, without initial detailed mapping, is a more efficient approach is not known. The study included 71 consecutive patients who had chronic AF. Using a nonfluoroscopic electroanatomic mapping system, the left and right superior pulmonary veins were ablated circumferentially at the venoatrial junction, with the aim of achieving electrical isolation of the veins. Following ablation, if frequent atrial ectopies were present, mapping and ablation were considered. The patients were periodically followed with 48-hour Holter and loop recorder monitoring. After the ablation of the right and left superior pulmonary veins 59 (83%) of 71 patients maintained sinus rhythm without premature atrial beats. The remaining 12 patients underwent further mapping and ablation including 5 patients who required isolation of the left inferior pulmonary veins. True electrical isolation could be achieved only in 45 (31%) of the 147 targeted veins. At the latest follow-up (mean 29 +/- 8 months), 80% of the patients with upper vein isolation remained in sinus rhythm off medications, 62% of the patients maintained sinus rhythm on previously ineffective medications, and 17% continued to be in AF. Fourteen (20%) patients developed intermittent episodes of left atrial flutter, and mapping in these patients revealed large electrically silent areas in the left atrium. Empirical isolation of pulmonary veins appeared to be an effective approach to help maintain sinus rhythm in patients with chronic AF. True electrical isolation of the pulmonary veins was associated with a higher likelihood of long-term success. Left atrial flutter was seen in a significant number of patients at long-term follow-up.
Development of the Low Loss LTCC Material Applied for Millimeter-wave Frequencies (2018)

New LTCC (Low Temperature Co-fired Ceramics) material that consists of Mg2SiO4, SrTiO3 and highly crystallized Li-Mg-B-Si-O glass was developed. The dielectric constant was 8.8 and Q value was 1620 at 25 GHz (Qf = 40500 GHz). And also, its temperature coefficient of dielectric constant τεr was +16 ppm/°C, which was much smaller than that of the existing LTCC material having high Q value. It is a promising LTCC material applying to the high frequency electric component.
Circuit techniques for 1.5-V power supply flash memory (1997)

We describe circuit techniques for a Flash memory which operates with a V/sub DD/ of 1.5 V. For the interface between the peripheral circuits and the memory core circuits, two types of level shifter circuits are proposed which convert a V/sub DD/ level signal into the high voltage signals needed for high performance. In order to improve the read performance at a low V/sub DD/, a new self-bias bitline voltage sensing scheme is described. This circuit greatly reduces the delay's dependence on bitline capacitance and achieves 19 ns reduction of the sense delay at low voltages. Multilevel storage sensing with this circuit is also discussed.
<title>Classification of compressed images using Fourier-transform-based invariants</title> (1994)

A novel approach for classification of deformed images is presented. It is shown that by using the Fourier phase of the deformed images, a set of invariants can be calculated and used for identification of each image. Phase-only, as is well known, is also good for compression and reconstruction of images. Computational results are presented and discussed.
Pathway Development and Pilot Library Realization in Diversity‐Oriented Synthesis. Exploring Ferrier and Pauson—Khand Reactions on a Glycal Template (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Susceptibility of bovine macrophages to infectious bovine rhinotracheitis virus infection (1982)

Infectious bovine rhinotracheitis virus replicated in cultured bovine alveolar macrophages (AM). However, yields of infectious virus were low, with maximum titers approximately 100 times that of the residual inoculum. Immunofluorescence and electron microscopic studies indicated that the majority of macrophages produced viral antigen, but after infection at a multiplicity of 0.1, only 4.1% of AM produced infectious centers. Virus-infected AM culture supernatants possessed interfering activity, probably due to interferon. Incubation of fresh AM with these fluids rendered them refractory to infection. Although AM from infectious bovine rhinotracheitis virus-immune and -susceptible donors were equally permissive and their susceptibility was unaltered by incubation with bacterial lipopolysaccharide, bovine mammary macrophages which were elicited with lipopolysaccharide became nonpermissive when further incubated for 48 h with 1 microgram of lipopolysaccharide per ml. Under these conditions, infected mammary macrophages failed to synthesize viral DNA, and there was reduced synthesis of "late" viral polypeptides.
Privacy-Aware Access Protocols for MEC Applications in 5G (2022)

Multi-access edge computing (MEC) is one of the emerging key technologies in fifth generation (5G) mobile networks, providing reduced end-to-end latency for applications and reduced load in the transport network. This paper proposes mechanisms to enhance user privacy in MEC within 5G. We consider a basic MEC usage scenario, where the user accesses an application hosted in the MEC platform via the radio access network of the mobile network operator (MNO). First, we create a system model based on this scenario. Second, we define the adversary model and give the list of privacy requirements for this system model. We also analyze the impact on user privacy when some of the parties in our model share information that is not strictly needed for providing the service. Third, we introduce a privacy-aware access protocol for the system model and analyze this protocol against the privacy requirements.
Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry (2021)

The ongoing COVID-19 pandemic has highlighted the immediate need for the development of antiviral therapeutics targeting different stages of the SARS-CoV-2 life cycle. We developed a bioluminescence-based bioreporter to interrogate the interaction between the SARS-CoV-2 viral spike (S) protein and its host entry receptor, angiotensin-converting enzyme 2 (ACE2). The bioreporter assay is based on a nanoluciferase complementation reporter, composed of two subunits, large BiT and small BiT, fused to the S receptor-binding domain (RBD) of the SARS-CoV-2 S protein and ACE2 ectodomain, respectively. Using this bioreporter, we uncovered critical host and viral determinants of the interaction, including a role for glycosylation of asparagine residues within the RBD in mediating successful viral entry. We also demonstrate the importance of N-linked glycosylation to the RBD's antigenicity and immunogenicity. Our study demonstrates the versatility of our bioreporter in mapping key residues mediating viral entry as well as screening inhibitors of the ACE2-RBD interaction. Our findings point toward targeting RBD glycosylation for therapeutic and vaccine strategies against SARS-CoV-2.
Session 27 overview: Biomedical circuits (2017)

Advances in biomedical circuits and systems are essential technology drivers in addressing critical societal needs to increase the effectiveness and reduce the cost of healthcare. This session highlights the latest circuit innovations that contribute to advances in medical devices, sensing and imaging. For implantable and unobtrusive devices, ultrasonic power delivery and telemetry, and improved neural sensing and stimulation are addressed. Advanced medical sensing increasingly combines multiple modalities in a single device, several examples of which are also featured in this session. Finally, circuit innovations enabling improved ultrasonic and magnetic resonance imaging and optical spectroscopy are presented.
Synthesis of Alternating trans-AB Copolymers through Ring-Opening Metathesis Polymerization Initiated by Molybdenum Alkylidenes (2015)

Four alternating AB copolymers have been prepared through ring-opening metathesis polymerization (ROMP) with Mo(NR)(CHCMe2Ph)[OCMe(CF3)2]2 initiators (R = 2,6-Me2C6H3 (1) or 2,6-i-Pr2C6H3 (2)). The A:B monomer pairs copolymerized by 1 are cyclooctene (A):2,3-dicarbomethoxy-7-isopropylidenenorbornadiene (B), cycloheptene (A'):dimethylspiro[bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate-7,1'-cyclopropane] (B'), A:B', and A':B; A':B' and A:B' are also copolymerized by 2. The >90% poly(A-alt-B) copolymers are formed with heterodyads (AB) that have the trans configuration. Evidence suggests that one trans hetero C═C bond is formed when A (A or A') reacts with the syn form of the alkylidene made from B (syn-MB = syn-MB or syn-MB') to give anti-MA, while the other trans C═C bond is formed when B reacts with anti-MA to give syn-MB. Cis and trans AA dyads are proposed to arise when A reacts with anti-MA in competition with B reacting with anti-MA.
Nucleation and Growth of Crystalline Silicon Films on Glass for Solar Cells (1998)

Understanding nucleation and growth of crystalline Si films on glass is of prime importance in order to tailor and optimize semiconductor properties for electronic devices such as solar cells. Commercial glass limits the maximum processing temperature of Si films to 600 °C. Solid phase and laser crystallization, or a combination of both techniques, are thus primarily used to crystallize Si films on glass. While random nucleation and growth processes always result in the formation of a log–normal size distribution, control of nucleation sites allows one to determine the location of grain growth or even the crystallographic orientation of grains. Via sequential lateral solidification using a copper vapor laser, we obtain Si crystallites on glass of several tens of μm in length.
Birth and growth of a granular jet (2008)

The interaction between fine grains and the surrounding interstitial gas in a granular bed can lead to qualitatively new phenomena not captured in a simple, single-fluid model of granular flows. This is demonstrated by the granular jet formed by the impact of a solid sphere into a bed of loose, fine sand. Unlike jets formed by impact in fluids, this jet is actually composed of two separate components, an initial thin jet formed by the collapse of the cavity left by the impacting object stacked on top of a second, thicker jet which depends strongly on the ambient gas pressure. This complex structure is the result of an interplay between ambient gas, bed particles, and impacting sphere. Here we present the results of systematic experiments that combine measurements of the jet above the surface varying the release height, sphere diameter, container size, and bed material with x-ray radiography below the surface to connect the changing response of the bed to the changing structure of the jet. We find that the interstitial gas trapped by the low permeability of a fine-grained bed plays two distinct roles in the formation of the jet. First, gas trapped and compressed between grains prevents compaction, causing the bed to flow like an incompressible fluid and allowing the impacting object to sink deep into the bed. Second, the jet is initiated by the gravity driven collapse of the cavity left by the impacting object. If the cavity is large enough, gas trapped and compressed by the collapsing cavity can amplify the jet by directly pushing bed material upwards and creating the thick jet. As a consequence of these two factors, when the ambient gas pressure is decreased, there is a crossover from a nearly incompressible, fluidlike response of the bed to a highly compressible, dissipative response. Compaction of the bed at reduced pressure reduces the final depth of the impacting object, resulting in a smaller cavity and in the demise of the thick jet.
Antibody response to core, envelope and nonstructural hepatitis C virus antigens: Comparison of immunocompetent and immunosuppressed patients (1993)

Some immunosuppressed patients with hepatitis C virus infection do not have detectable levels of antibody to hepatitis C virus on second-generation enzyme immunoassay. Antibodies to the envelope and nonstructural region 5 proteins have not been examined. Four groups of patients with hepatitis C virus infection were studied: (a) 20 immunocompetent patients, (b) 15 hemodialysis patients, (c) 17 kidney transplant recipients and (d) 3 acute leukemia patients who underwent bone marrow transplantation. Serum samples were tested for antibody to hepatitis C virus with a second-generation enzyme immunoassay and multi-antigen enzyme immunoassays and for hepatitis C virus RNA with a nested polymerase chain reaction assay. All the immunocompetent patients reacted to C25, C22 and C33C; 90% reacted to nonstructural region 5 antigen and 80% reacted to C100-3. Only 55% reacted against yeast-derived e1 and e2 antigens, but all reacted against vaccinia virus--expressed N e1 and e2 antigens, indicating that the envelope epitopes are conformational and glycosylated. Sixty-five percent to 90% of dialysis and kidney transplant patients reacted to C25, C22 and N e1 and e2, but only 12% to 60% reacted to C100-3, C33C and nonstructural region 5 antigen. Diminution or loss of reactivity to hepatitis C virus antigens was observed after kidney and bone marrow transplantation, with C25 and N e1 and e2 less affected. Our data suggest that incorporation of C25 and N e1 and e2 antigens in the assay for antibody to hepatitis C virus would improve the detection of hepatitis C virus infection in immunosuppressed patients.
Multiple-reaction monitoring liquid chromatography mass spectrometry for monosaccharide compositional analysis of glycoproteins (2009)

A simple, sensitive, and rapid quantitative LC-MS/MS assay was designed for the simultaneous quantification of free and glycoprotein bound monosaccharides using a multiple reaction monitoring (MRM) approach. This study represents the first example of using LC-MS/MS methods to simultaneously quantify all common glycoprotein monosaccharides, including neutral and acidic monosaccharides. Sialic acids and reduced forms of neutral monosaccharides are efficiently separated using a porous graphitized carbon column. Neutral monosaccharide molecules are detected as their alditol acetate anion adducts [M + CH(3)CO(2)](-) using electrospray ionization in negative ion MRM mode, while sialic acids are detected as deprotonated ions [M - H](-). The new method exhibits very high sensitivity to carbohydrates with limits of detection as low as 1 pg for glucose, galactose, and mannose, and below 10 pg for other monosaccharides. The linearity of the described approach spans over three orders of magnitudes (pg to ng). The method effectively quantified monosaccharides originating from as little as 1 microg of fetuin, ribonuclease B, peroxidase, and alpha(1)-acid glycoprotein human (AGP) with results consistent with literature values and with independent CE-LIF measurements. The method is robust, rapid, and highly sensitive. It does not require derivatization or postcolumn addition of reagents.
Progress and issues for computationally guided lead discovery and optimization (2010)

Since the late 1980s there have been striking advances, fueled by large increases in both industrial and NIH-funded academic research, that have revolutionized drug discovery. This period has seen the introduction of high-throughput screening (HTS), combinatorial chemistry, PC farms, Linux, SciFinder, structure-based design, virtual screening by docking, free-energy methods, absorption/distribution/metabolism/excretion (ADME) software, bioinformatics, routine biomolecular structure determination, structures for ion channels, G-protein-coupled receptors (GPCRs) and ribosomes, structure/activity relationships (SAR) obtained from nuclear magnetic resonance (SAR by NMR), fragment-based design, gene knockouts, proteomics, small interfering RNA (siRNA), and human genome sequences. The result is a much-accelerated progression from identification of biomolecular target to lead compound to clinical candidate. However, a serious concern is that the dramatic increase in drug discovery abilities and expenditures has not been paralleled by an increase in FDA approvals of new molecular entities. High demands for drug safety, broader and longer clinical trials, too much HTS, too little natural products research, and effective generic drugs for many once-pressing afflictions have all been suggested as contributors. Numerous corporate mergers and acquisitions may have also had adverse effects on productivity through distractions of reorganization and integration. Nevertheless, one should consider what the success would have been in the absence of the striking technical advances. Certainly, progress with some critical and challenging target classes such as kinases would have been greatly diminished, and the adverse impact on many cancer patients would have been profound.
ChemInform Abstract: PREPARATION AND SPECTROSCOPIC PROPERTIES OF COBALT(III) COMPLEXES CONTAINING PHOSPHINE LIGANDS. THE ELECTRONIC STRUCTURAL DESCRIPTION OF SIDE‐BONDED DIOXYGEN (1976)

Abstract Co‐perchlorat oder‐tetrafluoroborat reagiert mit cis‐l ,2‐Bis‐[diphenylphosphino]‐ äthylen zu den Verbindungen (I).
DRUT: An Efficient Turbo Boost Solution via Load Balancing in Decoupled Look-Ahead Architecture (2017)

In spite of the multicore revolution, high single thread performance still plays an important role in ensuring a decentoverall gain. Look-ahead is a proven strategy in uncoveringimplicit parallelism; however, a conventional out-of-ordercore quickly becomes resource-inefficient when looking beyond a short distance. An effective approach is to use an in-dependent look-ahead thread running on a separate contextguided by a program slice known as the skeleton. We observethat fixed heuristics to generate skeletons are often suboptimal. As a consequence, look-ahead agent is not able to targetsufficient bottlenecks to reap all the benefits it should.In this paper, we present DRUT, a holistic hardware-software solution, which achieves good single thread performance by tuning the look-ahead skeleton efficiently. First, we propose a number of dynamic transformations to branchbased code modules (we call them Do-It-Yourself or DIY)that enable a faster look-ahead thread without compromisingthe quality of the look-ahead. Second, we extend our tuningmechanism to any arbitrary code region and use a profile-driven technique to tune the skeleton for the whole program.Assisted by the aforementioned techniques, look-aheadthread improves the performance of a baseline decoupledlook-ahead by up to 1.93× with a geometric mean of 1.15×. Our techniques, combined with the weak dependence removal technique, improve the performance of a baselinelook-ahead by up to 2.12× with a geometric mean of 1.20×. This is an impressive performance gain of 1.61× over thesingle-thread baseline, which is much better compared toconventional Turbo Boost with a comparable energy budget.