gebhart/patrepeval huggingface dataset:
FatalTrichodermaharzianuminfection in a leukemic pediatric patient (2009)

We report the repeated isolation for Trichoderma.harzianum, a rare opportunistic pathogen from three sets of each of the following clinical samples; blood serum, skin lesions, sputum and throat of a pediatric ALL patient with neutropenia. The definition of invasive fungal infection requires evidence of the presence of fungal elements in tissue samples, in addition to the isolation of suspected etiologic agent in culture. However, invasive procedures are not always applicable due to several factors, as for example in our case, the poor general status of the individual patient or thrombocytopenia. The present paper also emphasizes the problems encountered in obtaining appropriate samples and diagnosing invasive fungal disease in immunocompromised patient populations, including those with hematological malignancy. Three cases involving T. harzianum, including this one, have been described thus far in the literature. All were fatal and the fungus was resistant to antifungal therapy. A critical review of the other two cases of Trichoderma infections in humans is provided.
Supplementary Figure 7 from Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity (2023)

Supplementary Figure 7 from Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity
Robust control of electrified turbocharged diesel engines (2016)

Electrified turbocharger is a critical technology for engine downsizing and is a cost-effective solution for exhaust gas energy recovery. In conventional turbocharged diesel engines, the air path holds strong nonlinearity since the actuators are all driven by the exhaust gas. In an electrified turbocharged diesel engine (ETDE), the coupling is more complex, due to the electric machine mounted on the turbine shaft impacts the exhaust manifold dynamics as well. In distributed single-input single-output control methods, the gains tuning is time consuming and the couplings are ignored. To control the performance variables independently, developing a promising multi-input multi-output control method for the ETDE is essential. In this paper, a model-based multi variable robust controller is designed to control the performance variables in a systematic way. Both simulation and experimental results verified the effectiveness of the proposed controller.
Annihilation upconversion: harvesting the entire deep-red spectral range of the sun irradiation (2017)

Solar energy storage and conversion is a key technology for the future realization of a sustainable energy production worldwide. The utilization of low-energy photons by means of upconversion (UC) processes has the main advantage of the upconversion process and solar energy-harvesting devices being considered and optimized independently, without affecting the particular physical characteristics of the operating sunlight excited material or device architectures. The UC-device must function efficiently with noncoherent light excitation, under light intensities comparable with those obtainable from moderate concentrated sunlight (1 to 20 suns, AM1.5); such a low degree of concentration allows usage of Fresnel-type focusing systems. We report chemical synthesis and efficient functioning of a triplet–triplet annihilation upconversion-based device, harvesting the entire deep-red spectral range of the sun irradiation (Δλ∼142 nm) in a gap-free manner.
HyperSegNAS: Bridging One-Shot Neural Architecture Search with 3D Medical Image Segmentation using HyperNet (2021)

Semantic segmentation of 3D medical images is a challenging task due to the high variability of the shape and pattern of objects (such as organs or tumors). Given the recent success of deep learning in medical image segmentation, Neural Architecture Search (NAS) has been introduced to find high-performance 3D segmentation network architectures. However, because of the massive computational requirements of 3D data and the discrete optimization nature of architecture search, previous NAS methods require a long search time or necessary continuous relaxation, and commonly lead to sub-optimal network architectures. While one-shot NAS can potentially address these disadvantages, its application in the segmentation domain has not been well studied in the expansive multi-scale multi-path search space. To enable one-shot NAS for medical image segmentation, our method, named HyperSegNAS, introduces a HyperNet to assist super-net training by incorporating architecture topology information. Such a HyperNet can be removed once the super-net is trained and introduces no overhead during architecture search. We show that HyperSegNAS yields better performing and more intuitive architectures compared to the previous state-of-the-art (SOTA) segmentation networks; furthermore, it can quickly and accurately find good architecture candidates under different computing constraints. Our method is evaluated on public datasets from the Medical Segmentation Decathlon (MSD) challenge, and achieves SOTA performances.
The Relative Weight Index in Fisheries Management: Status and Needs (1991)

The relative weight (Wr) index allows easy interpretation of condition for fish of various species and lengths. Rapid proliferation of index use, with a piecemeal approach to research on the index, has led to a confusing array of equations and methods for developing these equations. We recommend that the regression-line-percentile (RLP) technique be adopted as a standardized method for developing standard weight (Ws) equations, as good statistical consistency has been demonstrated for this approach. Equations should be modeled on 75th-percentile-weight data for consistent interpretation, and should be developed from data sets that represent the entire geographical range of a species. Standard weight should be considered a benchmark for comparison rather than a management target. Although the concept of a generalized “optimal” target range for Wr is attractive, Wr targets should be established for specific management objectives. Standard weight equations should be evaluated for length-related biases, and minimum applicable lengths for Wr use should be defined. Standard weight equations proposed should be published in peer-reviewed literature to facilitate effective application and evaluation by the management community. Application of rigorous criteria to development of Ws equations would standardize and clarify the theoretical basis of Wr applications. Further research is needed to clarify the relation of condition indices to other measures of population structure and dynamics, and to develop valid Ws equations for juvenile fish.
Controllability of Non-Linear Predictor-Based Dynamic Bandwidth Allocation Over EPONs (2007)

We analyze the dynamic bandwidth allocation (DBA) scheme over Ethernet passive optical networks (EPONs). Our focus is on the non-linear predictor-based DBA (NLPDBA), which outperforms other existing schemes with higher bandwidth utilization and shorter packet delay. We establish a system model to evaluate the controllability of NLPDBA. Analytical results show that NLPDBA maintains the EPON system controllability even when the loaded network traffic changes drastically. Our analysis suggests a straightforward framework to design the DBA scheme that would enable a completely controllable access network.
Perillyl Alcohol Inhibits Breast Cell Migration without Affecting Cell Adhesion (2002)

The monoterpene d-limonene exhibits chemotherapeutic and chemopreventive potential in breast cancer patients. D-limonene and its related compounds, perillyl alcohol and perillyl aldehyde, were chosen as candidate drugs for application in a screen for nontoxic inhibitors of cell migration. Using the nontumorigenic human breast cell line MCF-10A, we delineated the toxicity as greatest for the perillyl aldehyde, intermediate for perillyl alcohol, and least for limonene. A noncytotoxic concentration of 0.5 mmol/L perillyl alcohol inhibited the migration, while the same concentration of limonene failed to do so. Adhesion of the MCF-10A cell line and the human breast cancer cell line MDA-MB 435 to fibronectin was unaffected by 1.5 mmol/L perillyl alcohol. 0.4 mmol/L perillyl alcohol inhibited the growth of MDA-MB 435 cells. All migration-inhibiting concentrations of perillyl alcohol for MDA-MB 435 cells proved to be toxic. These results suggest that subtoxic doses of perillyl alcohol may have prophylactic potential in the treatment of breast cancer.
AUTOMATIC ESTIMATION OF SIZE PARAMETERS USING VERIFIED COMPUTERIZED STEREOANALYSIS (2011)

State-of-the-art computerized stereology systems combine high-resolution video microscopy and hardwaresoftware integration with stereological methods to assist users in quantifying multidimensional parameters of importance to biomedical research, including volume, surface area, length, number, their variation and spatial distribution. The requirement for constant interactions between a trained, non-expert user and the targeted features of interest currently limits the throughput efficiency of these systems. To address this issue we developed a novel approach for automatic stereological analysis of 2-D images, Verified Computerized Stereoanalysis (VCS). The VCS approach minimizes the need for user interactions with high contrast [high signal-to-noise ratio (S:N)] biological objects of interest. Performance testing of the VCS approach confirmed dramatic increases in the efficiency of total object volume (size) estimation, without a loss of accuracy or precision compared to conventional computerized stereology. The broad application of high efficiency VCS to high-contrast biological objects on tissue sections could reduce labor costs, enhance hypothesis testing, and accelerate the progress of biomedical research focused on improvements in health and the management of disease.
ChemInform Abstract: Exploitation of Microbiological Methods for the Synthesis of Biologically Active Natural Products and Analogues (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SoxR as a Single-Cell Biosensor for NADPH-Consuming Enzymes in Escherichia coli (2013)

An ultra-high-throughput screening system for NADPH-dependent enzymes, such as stereospecific alcohol dehydrogenases, was established. It is based on the [2Fe-2S] cluster-containing transcriptional regulator SoxR of Escherichia coli that activates expression of soxS in the oxidized but not in the reduced state of the cluster. As SoxR is kept in its reduced state by NADPH-dependent reductases, an increased NADPH demand of the cell counteracts SoxR reduction and increases soxS expression. We have taken advantage of these properties by placing the eyfp gene under the control of the soxS promoter and analyzed the response of E. coli cells expressing an NADPH-dependent alcohol dehydrogenase from Lactobacillus brevis (LbAdh), which reduces methyl acetoacetate to (R)-methyl 3-hydroxybutyrate. Under suitable conditions, the specific fluorescence of the cells correlated with the substrate concentration added and with LbAdh enzyme activity, supporting the NADPH responsiveness of the sensor. These properties enabled sorting of single cells harboring wild-type LbAdh from those with lowered or without LbAdh activity by fluorescence-activated cell sorting (FACS). In a proof-of-principle application, the system was used successfully to screen a mutant LbAdh library for variants showing improved activity with the substrate 4-methyl-2-pentanone.
Continuous Monitoring of Blood Volume in Double Filtration Plasmapheresis (1998)

A continuous hematocrit (HCT) monitor, Crit-Line, was introduced to examine the change in patients' blood volume (BV) due to albumin loss during double filtration plasmapheresis (DFPP) treatments. Nine patients with autoimmune diseases or ABO incompatible renal transplantation received 15 DFPP treatments under Crit-Line monitoring. In these patients, plasma albumin concentration (C(P)) changed from 3.7 +/- 0.6 g/dl to 3.5 +/- 0.5 g/dl and HCT from 28.7% +/- 3.3% to 31.3% +/- 4.3% (change ratio [CR] of BV = -8.1%) during treatment with albumin concentrations (C(S)) of 9.5 +/- 1.0 g/dl and 500 ml volumes (V(S)) of supplementation fluid. Although the apparent CR value of C(P) was -5.3%, on average, the CR of albumin in the patients' plasma (M(P)) was -16.1%, which means a corrected CR value of C(P) by the HCT value to eliminate the influence of the patient's blood volume contraction during treatment. Albumin loss usually occurred in DFPP treatments. The decrease in BV was induced by an oncotic pressure drop due to albumin loss, and often resulted in a blood pressure drop. The amount of albumin loss during DFPP treatments strongly depends on sieving coefficients of the plasma separator (SC(PS)) and the plasma fractionator (SC(PF)), the filtration fraction of the plasma fractionator (FF(PF)), pretreatment C(P) value, and C(S) and V(S) values of the supplementation fluid. To determine the optimum C(S) and V(S) values for each patient, the authors introduced a variable blood volume model for albumin transport in DFPP. In this model, changes in C(P), HCT, and BV values could be estimated during treatment. For example, a patient with an HCT of 31.2%, body weight of 61.1 kg, and pretreatment C(P) of 4.4 g/dl received a DFPP treatment using a plasma separator, OP-05 (SC(PS) of 0.99), and a plasma fractionator, Evaflux 2A (SC(PF) of 0.40), under FF(PF) of 0.8 with a V(S) of 500 ml. A value for C(S) of about 10 g/dl is required for the patient to maintain a normal C(P) level during treatment by an estimation from the model. As a result of the treatment with a C(S) of 10 g/dl, the patient had no adverse reactions, such as a blood pressure decrease, during treatment under these conditions.
Ornicorrugatin, a New Siderophore from Pseudomonas fluorescens AF76 (2008)

From a pyoverdin-negative mutant of Pseudomonas fluorescens AF76 a new lipopeptidic siderophore (ornicorrugatin) could be isolated. It is structurally related to the siderophore of Pseudomonas corrugata differing in the replacement of one Dab unit by Orn.
Evaluation of the efficacy of AIDS education interventions for homosexually active men (1990)

Due to an oversight the above article was wrongly accredited. Teh author's name was publisher incorrectly. The correct name is given below
Li.sub.2S batteries having high capacity, high loading, and high coulombic efficiency (2023)

An electrochemical device includes a cathode containing graphene-wrapped Li.sub.2S nanoparticles. The graphene-wrapped Li.sub.2S nanoparticles are prepared by a method including heating lithium metal, and a carbon-sulfur source or a carbon source and a sulfur source in a sealed container at a temperature to produce lithium vapors, and vapors of the carbon-sulfur source or vapors of the carbon source and vapors of the sulfur source; and cooling the sealed container to produce the graphene-wrapped Li.sub.2S nanoparticles.
Semiring-based trust evaluation for information fusion in social network services (2015)

As online social network services (SNS) are booming and gaining tremendous popularity, there is a sharply increasing amount of information exchange and interactions among SNS users. Taking this advantage, users in SNS make decisions via collecting and combining information from different sources (i.e. other users). However, there exists a large variance of trustworthiness among SNS populations, which is threatening the quality of the information fusion process. In such circumstances, trust relationships among users in SNS are very important in decision making as well as for the success of many SNS-based applications, e.g. recommender systems and ad targeting. An appropriate trust inference mechanism for trust evaluation is necessary in extending the knowledge base of trust opinions and tackle the issue of limited trust information due to link sparsity in social networks. In this work, we model the trust relationship among users in SNS as a 2-dimensional vector, and propose a semiring-based model for trust propagation and fusion as the building block of our trust inference framework. Specifically, in our approach, both trust and distrust (i.e., positive and negative trust) are both considered, and opinion conflict resolution is supported by our framework of trust inference.
Self-nucleation free and dimension dependent metal-induced lateral crystallization of amorphous germanium for single crystalline germanium growth on insulating substrate (2008)

In this work we have investigated Ni- or Au-induced crystallization and the lateral crystallization of planar amorphous germanium (α-Ge) on silicon dioxide at 360 °C without the deleterious effects of thermally induced self-nucleation. Subsequently, single crystalline Ge growth has been achieved on SiO2 by making dimension of α-Ge line to be smaller than the size of grains formed using Ni- and Au-induced lateral crystallizations at 360 °C. This method can be used to form the channel region of the MOS devices in upper layers of the three-dimensional integrated circuits at low temperatures.
Epigenetics: Novel Therapeutics Targeting Epigenetics (2016)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTEpigenetics: Novel Therapeutics Targeting EpigeneticsStuart J. Conway, Patrick M. Woster, William J. Greenlee, Gunda Georg, and Shaomeng WangView Author Information University of Oxford, United Kingdom Medical University of South Carolina, United StatesCite this: J. Med. Chem. 2016, 59, 4, 1247–1248Publication Date (Web):January 29, 2016Publication History Published online29 January 2016Published inissue 25 February 2016https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00098https://doi.org/10.1021/acs.jmedchem.6b00098editorialACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3871Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (138 KB) Get e-AlertscloseSUBJECTS:Genetics,Inhibitors,Ligands,Medicinal chemistry,Peptides and proteins Get e-Alerts
Cover Picture: Serine Octamer Reactions: Indicators of Prebiotic Relevance (Angew. Chem. Int. Ed. 30/2003) (2003)

In the beginning the origin of life involved a series of homochiral chemical reactions. Some of these may have involved serine and its homochiral octamer, as shown. Many of these reactions occur in a chirally selective fashion. The chiral exchange reactions favor the enantiomers present in modern life ( L ‐amino acids, D ‐sugars). More information on the homochiral serine octamer and its role in the prebiotic mechanisms that led to the origin of life are given by R. G. Cooks et al. on page 3521 ff.
How can routers help Internet economics? (1998)

Article Free Access Share on How can routers help Internet economics? Author: John M. Schnizlein Cisco Systems, San Jose, CA Cisco Systems, San Jose, CAView Profile Authors Info & Claims ICE '98: Proceedings of the first international conference on Information and computation economiesOctober 1998 Pages 52–59https://doi.org/10.1145/288994.289005Online:28 October 1998Publication History 0citation352DownloadsMetricsTotal Citations0Total Downloads352Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell (2001)

Multicellular animal development depends on integrins. These adhesion receptors link to the actin cytoskeleton, transmitting biochemical signals and force during cell migration and interactions with the extracellular matrix. Many integrin‐cytoskeleton connections are formed by filamins and talin. The β7 integrin tail binds strongly to filamin and supports less migration, fibronectin matrix assembly and focal adhesion formation than either the β1D tail, which binds strongly to talin, or the β1A tail, which binds modestly to both filamin and talin. To probe the role of filamin binding, we mapped the filamin-binding site of integrin tails and identified amino acid substitutions that led to selective loss of filamin binding to the β7 tail and gain of filamin binding to the β1A tail. These changes affected cell migration and membrane protrusions but not fibronectin matrix assembly or focal adhesion formation. Thus, tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization.
Improvement of Power and Signal Integrity through Layer Assignment in High-Speed Memory Systems (2019)

In high-speed systems, large switching current drawn from power supply seriously degrades the system performance. This paper discloses a signal integrity (SI) issue related to power integrity (PI). A high-speed memory subsystem is used to evaluate the impact of switching current on SI using eye diagrams. Several test cases are studied to clarify the signal susceptibility from the voltage variation of power due to switching current. Full-wave and circuit simulations are used to validate the hypothesis of noise immunity.