gebhart/patrepeval huggingface dataset:
Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival (2003)

Deregulation of the p16INK4a-cyclin D:cyclin-dependent kinases (cdk) 4/6-retinoblastoma (pRB) pathway is a common paradigm in the oncogenic transformation of human cells and suggests that this pathway functions linearly in malignant transformation. However, it is not understood why p16INK4a and cyclin D:cdk4/6 mutations are disproportionately more common than the rare genetic event of RB inactivation in human malignancies such as melanoma. To better understand how these complexes contribute to altered tissue homeostasis, we blocked cdk4/6 activation and acutely inactivated Rb by conditional mutagenesis during mouse hair follicle cycling. Inhibition of cdk4/6 in the skin by subcutaneous administration of a membrane-transducible TAT-p16INK4a protein completely blocked hair follicle growth and differentiation. In contrast, acute disruption of Rb in the skin of homozygous RbLoxP/LoxP mice via subcutaneous administration of TAT-Cre recombinase failed to affect hair growth. However, loss of Rb resulted in severe depigmentation of hair follicles. Further analysis of follicular melanocytes in vivo and in primary cell culture demonstrated that pRB plays a cell-autonomous role in melanocyte survival. Moreover, functional inactivation of all three Rb family members (Rb, p107, and p130) in primary melanocytes by treatment with a transducible TAT-E1A protein did not rescue the apoptotic phenotype. These findings suggest that deregulated cyclin D:cdk4/6 complexes and pRB perform nonoverlapping functions in vivo and provide a cellular mechanism that accounts for the low incidence of RB inactivation in cancers such as melanoma.
P1577Device-measured third heart sound predicts heart failure events better than auscultated third heart sound (2017)

Aim: Familial hypercholesterolemia (FH) is the first inherited disease which has been detected to cause myocardial infarction. There are studies about the association of specific cardiac arrhythmias with lipid profile in the literature, but there are no studies with FH patients. This study aimed to investigate the cardiac arrhythmia profile in FH patients. Methods: We included 49 patients with a diagnosis of FH (31 female, 18 male, mean age 50. 24-hour rhythm monitoring data for investigation of cardiac arrhythmias were recorded. In the FH group, patients' WHO FH scores were calculated. Results: Mean FH scores of the patients in the FH group were found to be 9.0 6 2.6. Arcus cornea, xanthelasma and tendinous xanthomas were significantly higher in FH group (p0.001, p0.001, p0.045). When compared to controls, FH patients had significantly higher rates of VES (p0.007), SVE (p0.022) and SVT (p0.498). In the regression analysis, the presence of arcus cornea was only independent predictor of SVT (with the increased risk of 20.8%). FH score was found to be only independent predictor of VES frequency (p0.005). The cut off value of FH score obtained by ROC curve was 8 for prediction of supraventricular arrhythmias (sensitivity:76.0%, specificity:70.0%). The area under the curve (AUC) was 0.840 (p<0.001). The cut off value of FH score obtained by ROC curve was 8 for prediction of ventricular arrhythmias (sensitivity:73.7%, specificity:64.0%). The area under the curve (AUC) was 0.753 (p0.001). Conclusion: FH increases the frequency of atrial and ventricular arrhythmias. But there is a need for multicenter studies with larger population.
Pure AlN layers in metal-polar AlGaN/AlN/GaN and AlN/GaN heterostructures grown by low-temperature ammonia-based molecular beam epitaxy (2015)

When grown at a high temperature (820 °C) by ammonia-based molecular beam epitaxy (NH3-MBE), the AlN layers of metal-polar AlGaN/AlN/GaN heterostructures had a high GaN mole fraction (∼0.15), as identified by atom probe tomography in a previous study (Mazumder et al 2013 Appl. Phys. Lett. 102 111603). In the study presented here, growth at low temperature (<740 °C) by NH3-MBE yielded metal-polar AlN layers that were essentially pure at the alloy level. The improved purity of the AlN layers grown at low temperature was correlated to a dramatic increase in the sheet density of the two-dimensional electron gas (2DEG) at the AlN/GaN heterointerface. Through application of an In surfactant, metal-polar AlN(3.5 nm)/GaN and AlGaN/AlN(2.5 nm)/GaN heterostructures grown at low temperature yielded low 2DEG sheet resistances of 177 and 285 Ω/□, respectively.
Framework Conceitual Utilizando BPM para Identificação e Tratamento de Dados Pessoais e Sensíveis de Doadores de um Serviço de Hemoterapia (2023)

Anais da 2ª Conferência Brasileira de Planejamento Experimental e Análise de Dados: ConBraPA 2022 (978-85-5722-443-8) - Framework Conceitual Utilizando Bpm Para Identificação E Tratamento De Dados Pessoais E Sensíveis De Doadores De Um Serviço De Hemoterapia
Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer (2004)

Abstract The transcription factor activator protein-2α (AP-2α) has recently been implicated as a tumor suppressor protein that can be lost during tumor progression and that exhibits growth-inhibitory properties when overexpressed in cancer cell lines. We now demonstrate that hypermethylation of a discrete 5′ region within a promoter CpG island of the gene is associated in breast cancer with the loss of AP-2α expression. Multiple CpG sites within the island become hypermethylated during breast cancer evolution. However, only hypermethylation of the most CpG-rich region, a small, ∼300-bp area at the 3′ end of exon 1, fully distinguishes neoplastic from normal breast tissue and correlates with transcriptional silencing. In cell culture, silenced AP-2α, associated with exon 1 hypermethylation, is re-expressed by 5-aza-2′deoxycytidine resulting in the restoration of a functional DNA sequence-specific binding protein. In vivo, as detected by a very sensitive nested PCR approach, methylation of the discrete AP-2α exon 1 region does not occur in normal breast epithelium and occurs in only 3 (16%) of 19 ductal carcinoma in situ (DCIS) lesions, but is present in 12 (75%) of 16 invasive breast tumors (P &amp;lt; 0.001; DCIS versus invasive cancers). Tumors unmethylated for this region expressed AP-2α protein throughout, whereas tumors with hypermethylation showed large areas of loss. Our studies then determine that hypermethylation of a small region of a CpG island correlates with silencing of AP-2α in breast cancer and suggest that inactivation of this gene could be a factor in, and a useful marker for, the progression of DCIS lesions.
Modeling of multileg sine-wave inverters: a geometric approach (1999)

Three fundamental sine-wave inverter topologies are analyzed: two-leg (one-phase, two-wire); three-leg (three-phase, three-wire); and four-leg (three-phase, four-wire). The topologies are "full-bridge" voltage-source inverters with LC filters suitable for producing sinusoidal output voltages. The switching states and corresponding output voltage vectors produced by each inverter are identified and presented along with an analysis of the geometric arrangement of these voltage vectors. A pattern of characteristics is established whereby the "qd" modeling forms commonly used with three-leg inverters are extended to address the expanded capabilities of the four-leg inverter. A unique 4/spl times/4 decoupling transformation matrix is presented for the four-leg inverter that enables direct transformation between the four-degree-of-freedom (DOF) leg-modulation space of the inverter and its corresponding 3-DOF output-voltage space. This is shown to be directly analogous to the well-known "abc-qd" transformation developed for the three-leg inverter. Fully decoupled models for each inverter are presented.
Randomized modulation schemes for power converters governed by Markov chains (2002)

Randomized modulation of switching in power converters holds promise in reducing input filtering requirements and in reducing acoustic noise in motor drive applications. This paper is devoted to issues in analysis and synthesis of randomized modulation schemes based on finite Markov chains. The main advantage of this novel type of randomized modulation is the availability of an explicit control of time-domain performance, in addition to the possibility of shaping the power spectra of signals of interest. Numerical (Monte Carlo) and experimental verifications for our power spectral formulas are presented. We also formulate representative narrow- and wide-band synthesis problems in randomized modulation, and solve them numerically. Our results suggest that randomized modulation is very effective in satisfying narrow-band constraints, but has limited effectiveness in meeting wide-band signal power constraints.
Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection (2022)

Patients with SARS-CoV-2 infection (COVID-19) risk developing long-term neurologic symptoms after infection. Here, we identify biomarkers associated with neurologic sequelae one year after hospitalization for SARS-CoV-2 infection. SARS-CoV-2-positive patients were followed using post-SARS-CoV-2 online questionnaires and virtual visits. Hospitalized adults from the pre-SARS-CoV-2 era served as historical controls. 40% of hospitalized patients develop neurological sequelae in the year after recovery from acute COVID-19 infection. Age, disease severity, and COVID-19 infection itself was associated with additional risk for neurological sequelae in our cohorts. Glial fibrillary astrocytic protein (GFAP) and neurofilament light chain (NF-L) were significantly elevated in SARS-CoV-2 infection. After adjusting for age, sex, and disease severity, GFAP and NF-L remained significantly associated with longer term neurological symptoms in patients with SARS-CoV-2 infection. GFAP and NF-L warrant exploration as biomarkers for long-term neurologic complications after SARS-CoV-2 infection.
Supplementary Information from Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis (2023)

&lt;p&gt;Supplementary methods, notes, figures, tables, video captions, and references&lt;/p&gt;
Aerodynamic Constraints for Vortex Trapping Airfoils (2002)

Nota di BERNARDO GALLETTI, ANGELO IOLLO e del Socio corrispondente LUCA ZANNETTI presentata nell'adunanza del 12 Giugno 2002 Riassunto. Si mostra come è possibile ricavare la geometria del profilo capace di catturare un vortice che realizza una data distribuzione di velocità, essendo tale distribuzione di velocità assegnata in funzione dell'ascissa curvilinea fissata sul contorno del profilo. Vengono altresí espressi i vincoli che detta distribuzione deve soddisfare affinché il problema risulti ben posto.
On-demand key distribution for body area networks for emergency case (2014)

Recent growth in the Wireless Sensor Networks (WSNs) has given rise to development of new and innovative medical applications. WSNs have occupied the medical area with immense benefits in reducing healthcare costs, doctor-patient efficiency, and enhanced openness for patients and healthcare professionals. Such sensors can be placed in or over a patient's body, forming a Body Area Network (BAN), to monitor the patient's health and vitalities. In these health monitoring applications, sensitive personal information is being transmitted over a network, thus, security needs to be embedded into the system from the start to guarantee privacy of the personal medical information. However, information security incurs additional overhead to the already resource-constrained BANs. This paper aims to provide a resource-efficient, scalable, and lightweight key management algorithm for cases of medical emergency, where a patient requires immediate medical assistance. The proposed key management algorithm securely establishes a key between a patient and the medical staff with minimal overhead without any prior knowledge of one another. The results show that the proposed scheme scales well with increasing number of nodes.
BM3D-PRGAMP: Compressive phase retrieval based on BM3D denoising (2016)

The explosion of computational imaging has seen the frontier of image processing move past linear problems, like denoising and deblurring, and towards non-linear problems such as phase retrieval. There has a been a corresponding research thrust into non-linear image recovery algorithms, but in many ways this research is stuck where linear problem research was twenty years ago: Models, if used at all, are simple designs like sparsity or smoothness. In this paper we use denoisers to impose elaborate and accurate models in order to perform inference on generalized linear systems. More specifically, we use the state-of-the-art BM3D denoiser within the Generalized Approximate Message Passing (GAMP) framework to solve compressive phase retrieval. Our method demonstrates recovery performance equivalent to existing techniques using fewer than half as many measurements. This dramatic improvement in compressive phase retrieval performance opens the door for a whole new class of imaging systems.
Design of a Full‐Profile‐Matching Solution for High‐Throughput Analysis of Multiphase Samples Through Powder X‐ray Diffraction (2009)

Few solutions that aim to identify crystalline materials from the analysis of powder X-ray diffraction (XRD) data have been reported to date. A careful inspection of the powder XRD data, and the corresponding highlight of specific failures when it has been used for the determination of the crystallographic phases of zeolites among mixtures, has allowed the creation of the recently proposed strategy: adaptable time warping (ATW). Herein, the design process is thoroughly detailed in a step-by-step manner, which allows a deep understanding of the motivations, improvements, and the resulting remarkable properties of our methodology. Because the use of high-throughput (HT) techniques for the discovery or for increasing the breadth of the synthetic routes of new microporous crystalline structures makes the reliability of search-match methods a critical factor to be assessed, a meticulous evaluation of the reliability and the robustness is provided and supported by both empirical comparisons and mathematical proof. The results offered by our methodology, which clearly outperforms the well-established solutions, open the way towards total automation of such a routine procedure, eliminating laborious and time-consuming controls, preliminary treatments, and settings. Consequently, the proposed solution is of great interest and appears to be very promising, not only because of the numerous potential applications of XRD in materials science, but also the possible expansion of the solution to several other characterization techniques.
Hyperfine splitting of the interaction energy in H plus D and in D plus D. (1968)

Hyperfine interaction of ground state D atom with ground state H or D atom, obtaining interaction energy hyperfine splitting and potential energy curves
The Effect of Variations in Operator Proficiency on Asw Combat System Performance (1993)

The development of an operability model analysis tool to support design requirement definition for advanced ASW combat systems has evolved over the last four years. Previous NUWC ASW Combat System Operability Modeling efforts using SLAM II have produced comparisons between various ASW combat systems to examine the relative benefits of equipment features and operating concepts. Development of these operability models enabled the representation of contact data handling processes, ASW combat system operators, and the man-to-man, man-to-machine, and machine-to-machine interfaces that occur during an ASW mission. Early operability model studies (Stretton, Swiontek, Morris, Conway, and Wachter, 1991) investigated data handling bottlenecks and contact data throughput for ASW systems by focusing on the sensor operators, supervisory personnel, and command decision makers. Earlier models did not incorporate variations in team member productivity as might be found under high-workload conditions. Also, ASW team member skill levels were not varied as might be found due to latency from training-to-shipboard activities or to individual differences in operators and their training. As a follow-on-effort, this study examined how variations in operator proficiency on critical tasks affect overall ASW combat system performance. Results of this effort appear to have wide-reaching operational impacts in the area of team performance and operator variability.
Smart and Secure Wireless Communications via Reflecting Intelligent Surfaces: A Short Survey (2020)

With the emergence of the Internet of Things (IoT) technology, wireless connectivity should be more ubiquitous than ever. In fact, the availability of wireless connection everywhere comes with security threats that, unfortunately, cannot be handled by conventional cryptographic solutions alone, especially in heterogeneous and decentralized future wireless networks. In general, physical layer security (PLS) helps in bridging this gap by taking advantage of the fading propagation channel. Moreover, the adoption of reconfigurable intelligent surfaces (RIS) in wireless networks makes the PLS techniques more efficient by involving the channel into the design loop. In this article, we conduct a comprehensive literature review on the RIS-assisted PLS for future wireless communications. We start by introducing the basic concepts of RISs and their different applications in wireless communication networks and the most common PLS performance metrics. Then, we focus on the review and classification of RIS-assisted PLS applications, exhibiting multiple scenarios, system models, objectives, and methodologies. In fact, most of the works in this field formulate an optimization problem to maximize the secrecy rate (SR) or secrecy capacity (SC) at a legitimate user by jointly optimizing the beamformer at the transmitter and the RIS's coefficients, while the differences are in the adopted methodology to optimally/sub-optimally approach the solution. We finalize this survey by presenting some insightful recommendations and suggesting open problems for future research extensions.
An agile radio framework for unmanaged wireless environments (2009)

The proposed demonstration is based on commodity 802.11 wireless cards and a low cost 2.4GHz sniffing device and shows how current WLAN based networks can benefit from spectrum awareness and dynamic access to the assigned band. The demonstrator presents a solution to problems in current wireless networks, like inefficient radio spectrum usage and limited ability to withstand interferences. The presented spectrum-aware radio management framework flexibly negotiates transmission parameters based on spectrum usage and application requirements and opportunistically utilizes available bandwidth. A key feature of this demonstrator is the fact that it breaks the traditional fixed channel bandwidth limitation and enables dynamic bandwidth allocation according to the needs of applications. It continuously monitors the assigned spectrum, tracks application behaviour, and dynamically adapts to the radio environment, such as interference and competition. Furthermore, a cross-media roaming mechanism is provided in the framework to support seamless handovers within and between radio technologies. Our enhancements are transparent to upper layer applications and will automatically benefit any software using network resources. The presented demonstrator uses wireless video streaming in a typical household scenario to illustrate the benefits without changes to the multimedia applications.
Disordered Pentasil-Type Borosilicates (1989)

The synthesis of pentasil-type borosilicates, referred to as BOR-E, from hydrogels containing a binary mixture of Me4N+/(n-Pr)4N+, Et4N+/(n-But)4N+ or Me4N+/(n-But)4N+ cations is described. Mirror plane-based stacking faults, randomly distributed in the ZSM-5-type (BOR-C) inversion center-based stacking of pentasil layers were identified in the framework structure of BOR-E by X-ray diffraction analysis. The probability of the occurrence of stacking faults, p, was estimated from X-ray diffraction data following a method developed for structure determination of a ZSM-11 type borosilicate (BOR-D). p ranges from 0 to 0.2, compared to 0 and 0.25 determined for BOR-C and BOR-D, respectively. The probability is dependent on both the cation pair used in the reaction mixture and the resulting relative abundance of the cations within the pores.
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb–Pb collisions at sNN=2.76 TeV (2013)

Anisotropic flow of charged hadrons, pions and (anti-)protons measured
New England harbor seal H3N8 influenza virus retains avian-like receptor specificity (2016)

An influenza H3N8 virus, carrying mammalian adaptation mutations, was isolated from New England harbor seals in 2011. We sought to assess the risk of its human transmissibility using two complementary approaches. First, we tested the binding of recombinant hemagglutinin (HA) proteins of seal H3N8 and human-adapted H3N2 viruses to respiratory tissues of humans and ferrets. For human tissues, we observed strong tendency of the seal H3 to bind to lung alveoli, which was in direct contrast to the human-adapted H3 that bound mainly to the trachea. This staining pattern was also consistent in ferrets, the primary animal model for human influenza pathogenesis. Second, we compared the binding of the recombinant HAs to a library of 610 glycans. In contrast to the human H3, which bound almost exclusively to α-2,6 sialylated glycans, the seal H3 bound preferentially to α-2,3 sialylated glycans. Additionally, the seal H3N8 virus replicated in human lung carcinoma cells. Our data suggest that the seal H3N8 virus has retained its avian-like receptor binding specificity, but could potentially establish infection in human lungs.
Induction therapy: clinical and quality of life outcomes in aged renal transplant recipients (2014)

Contrary to the common practice, T-cell depletion in recipients ≥ 50 yr of age may be beneficial.
A New Kinematic Kalman Filter (KKF) for End-Effector Sensing of Robotic Manipulators (2007)

The kinematic Kalman filter (KKF) is a sensor-based state estimator which is immune to the external disturbances and the parameter uncertainties of mechanical plants. This paper extends the original idea of the KKF to a more general form as a means to enhance a real time vision sensor for the end-effector control of a robot manipulator, the performance of which is often limited by its slow sampling rate. The original one-dimensional KKF is reformulated in a higher dimensional form by incorporating the measurements from the vision sensor, accelerometers and gyroscopes. A nonlinear state space model of the kinematics of the end-effector is derived including the time delay associated with vision sensing. Then, the new KKF is formulated as a state estimator combining the inter-sample predictions with an extended Kalman filter (EKF). The paper discusses practical issues such as the real time computation to implement the EKF and the vision sensor to measure the absolute position. Experimental results are presented to confirm the benefits of the new KKF using a two-link direct drive manipulator equipped with a dual axis MEMS accelerometer, a single axis MEMS gyroscope and an end-effector mounted vision camera. The accurate estimation of the position and velocity of the end-effector from the new KKF will be useful for the real time visual-servo and the task space control of robot manipulators.