gebhart/patrepeval huggingface dataset:
The effect of methylphenidate treatment on psychopathic behavior of patients having attention-deficit hyperactivity disorder with and without oppositional defiant disorder (2018)

To evaluate the effect of 3 months of methylphenidate (MPH) treatment on psychopathic behavior in children having attention-deficit hyperactivity disorder (ADHD) with and without comorbid oppositional defiant disorder (ODD). Twenty-seven children with Diagnostic and Statistical Manual of Mental Disorders, fifth ed., ADHD (13 female/14 male; aged 13.3±2.2 years old) were compared to an age/sex matched ADHD/ODD group (N=27, eight female/19 male; aged 11.8±1.9 years). The attention-deficit hyperactivity disorder rating scale (ADHD-RS) and the California Child Q-Set (CCQ) were used in both groups before MPH treatment (0.8-1.2 mg/kg/day) and 3 months thereafter. Significant reduction in the ADHD-RS scores was detected following MPH treatment in both the ADHD/ODD group and in the ADHD group (P<0.0011 and P=0.0012, respectively). Reduction in the CCQ scores was obtained in the ADHD/ODD group (P=0.0001) but not in in the ADHD group (P=0.18). A correlation was found between the reductions in the ADHD-RS and CCQ scores following MPH treatment in the ADHD/ODD group (Spearman's r=0.43, P=0.024). MPH treatment in children with ADHD/ODD was associated with reduction in psychopathic scores, and the reduction correlated with a corresponding improvement in their ADHD severity.
ChemInform Abstract: Methyl 5‐O‐tert‐Butyldiphenylsilyl‐2‐deoxy‐D‐threo‐pentofuranoside. An Approach to the Synthesis of 3′‐Substituted 2′,3′‐Dideoxynucleosides Including 3′‐Azido‐3′‐deoxythymidine and of 3′‐Substituted 2′,3′‐Dideoxy‐C‐nucleosides. (1988)

ChemInformVolume 19, Issue 3 Natural Products ChemInform Abstract: Methyl 5-O-tert-Butyldiphenylsilyl-2-deoxy-D-threo-pentofuranoside. An Approach to the Synthesis of 3′-Substituted 2′,3′-Dideoxynucleosides Including 3′-Azido-3′-deoxythymidine and of 3′-Substituted 2′,3′-Dideoxy-C-nucleosides. G. W. J. FLEET, G. W. J. FLEET Dyson Perrins Lab., Univ., Oxford OX1 3QY, U. K.Search for more papers by this authorJ. C. SON, J. C. SON Dyson Perrins Lab., Univ., Oxford OX1 3QY, U. K.Search for more papers by this author G. W. J. FLEET, G. W. J. FLEET Dyson Perrins Lab., Univ., Oxford OX1 3QY, U. K.Search for more papers by this authorJ. C. SON, J. C. SON Dyson Perrins Lab., Univ., Oxford OX1 3QY, U. K.Search for more papers by this author First published: January 19, 1988 https://doi.org/10.1002/chin.198803341AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume19, Issue3January 19, 1988 RelatedInformation
Bispecific T-Cell Engagers Targeting Membrane-Bound IgE (2021)

The increased incidence of allergies and asthma has sparked interest in IgE, the central player in the allergic response. Interaction with its high-affinity receptor FcεRI leads to sensitization and allergen presentation, extracellular membrane-proximal domain in membrane IgE can act as an antigen receptor on B cells, and the interaction with low-affinity IgE receptor CD23 additionally influences its homeostatic range. Therapeutic anti-IgE antibodies act by the inhibition of IgE functions by interfering with its receptor binding or by the obliteration of IgE-B cells, causing a reduction of serum IgE levels. Fusion proteins of antibody fragments that can act as bispecific T-cell engagers have proven very potent in eliciting cytotoxic T-lymphocyte-mediated killing. We have tested five anti-IgE Fc antibodies, recognizing different epitopes on the membrane-expressed IgE, for the ability to elicit specific T-cell activation when expressed as single-chain Fv fragments fused with anti-CD3ε single-chain antibody. All candidates could specifically stain the cell line, expressing the membrane-bound IgE-Fc and bind to CD3-positive Jurkat cells, and the specific activation of engineered CD3-overexpressing Jurkat cells and non-stimulated CD8-positive cells was demonstrated for 8D6- and ligelizumab-based bispecific antibodies. Thus, such anti-IgE antibodies have the potential to be developed into agents that reduce the serum IgE concentration by lowering the numbers of IgE-secreting cells.
Microgravity environment grown crystal structure information based engineering of direct electron transfer type glucose dehydrogenase (2022)

The heterotrimeric flavin adenine dinucleotide dependent glucose dehydrogenase is a promising enzyme for direct electron transfer (DET) principle-based glucose sensors within continuous glucose monitoring systems. We elucidate the structure of the subunit interface of this enzyme by preparing heterotrimer complex protein crystals grown under a space microgravity environment. Based on the proposed structure, we introduce inter-subunit disulfide bonds between the small and electron transfer subunits (5 pairs), as well as the catalytic and the electron transfer subunits (9 pairs). Without compromising the enzyme's catalytic efficiency, a mutant enzyme harboring Pro205Cys in the catalytic subunit, Asp383Cys and Tyr349Cys in the electron transfer subunit, and Lys155Cys in the small subunit, is determined to be the most stable of the variants. The developed engineered enzyme demonstrate a higher catalytic activity and DET ability than the wild type. This mutant retains its full activity below 70 °C as well as after incubation at 75 °C for 15 min - much higher temperatures than the current gold standard enzyme, glucose oxidase, is capable of withstanding.
User Proximity Analysis of Compact PIFA for MIMO Applications (2019)

In this paper, the effect of user's body is studied over previously proposed antenna. The effect of “Specific Anthropomorphic Mannequin (SAM) head and PDA hand (Talk mode)”, “Personal Digital Assistants (PDA) hand (Data mode)”, and “Dual hands (Read mode)” are studied for diversity performances. There are two different positions of the antenna over mobile circuit board is considered i.e., antenna at the top position and bottom position of the mobile circuit board. In the user proximity, the optimal location of the antenna over circuit board is chosen for real application based on the antenna performance parameters i.e. diversity parameters. The specific absorption rate (SAR) for American standard (1.6W/kg average over 1g tissues) and European standard (2W/kg average over 10g tissues) is calculated for the top and bottom position of the MIMO antenna elements and it is found that the values of SAR are well below the standard limit of FCC as well as European standard. Based on the study, it is found that antenna at the top position of mobile circuit board shows overall better performance in the presence of user's body.
L'esperienza del new labour. Un'analisi critica della politica e delle politiche (2010)

I governi New Labour hanno profondamente trasformato la Gran Bretagna inventando un cocktail originale composto da tre quarti di riforme neoliberiste e antiliberali ispirate dall'esempio americano, un poco di social-democrazia scandinava e un forte desiderio di sperimentazione. Governando il Paese e il Partito a forza di slogan e indicatori di performance, mischiati a una convinzione e una leadership straordinarie, Tony Blair è riuscito a far accettare ai cittadini una serie di riforme radicali dell'amministrazione e dei servizi pubblici. Gordon Brown, meno popolare, è giunto al governo in una situazione di crisi economica senza precedenti... aggravata dalle politiche implementate dai suoi stessi predecessori. I neolaburisti, dopo tre mandati elettorali, sono finiti usurati dal potere e senza più ispirazione.\nIl New Labour è un buon modello a cui può ispirarsi la sinistra italiana ed europea?\nPerché è stato sconfitto così clamorosamente alle ultime elezioni ? Dopo tanta enfasi e clamore sulla proposta iniziale di una Terza via, cosa è stato veramente in grado di fare, e con quali esiti ? Il Regno Unito è oggi una società più giusta ?\nIl libro presenta un bilancio e una brillante analisi dei governi neolaburisti di Tony Blair e Gordon Brown (1997-2010): una rivoluzione burocratica che continua a diffondersi in Italia e in Europa, e che merita di essere conosciuta e discussa a fondo come segnalano la prefazione di Roberto Biorcio e Tommaso Vitale e la postfazione di Fabrizio Barca.
Electroosmotic Flow Field Measurements With Particle Image Velocimetry (2000)

Abstract A micron-resolution particle image velocimetry (PIV) system has been developed to spatially and temporally resolve electroosmotic flow fields within microfluidic bioanalytical devices. A second diagnostic technique, particle tracking velocimetry (PTV) has been used to determine the distribution of electrophoretic mobilities of seed particles and thereby make the PIV measurements quantitative. This second particle tracking technique has been used to determine probability distribution functions of the seed particles. Results from simulations of electric fields yield local electric field strengths in the geometries of interest. The measured mean mobility of the seed particles (obtained from PTV measurements) is then multiplied by the local electric field vector to obtain the electrophoretic velocity. The variance on the particle mobility measurement influences the errors introduced in the electroosmotic flow measurements. After total particle velocities are measured within a microfluidic system of interest, the seed particle electrophoretic velocities are subtracted from the PIV total velocity data to obtain electroosmotic flow field velocities. Ensemble-averaged velocity field measurements for electroosmotic flow at the intersection of a cross-channel are presented.
Dynamic heterogeneity and the need for multicore virtualization (2009)

As the computing industry enters the multicore era, exponential growth in the number of transistors on a chip continues to present challenges and opportunities for computer architects and system designers. We examine one emerging issue in particular: that of dynamic heterogeneity, which can arise, even among physically homogeneous cores, from changing reliability, power, or thermal conditions, different cache and TLB contents, or changing resource configurations. This heterogeneity results in a constantly varying pool of hardware resources, which greatly complicates software's traditional task of assigning computation to cores. In part to address dynamic heterogeneity, we argue that hardware should take a more active role in the management of its computation resources. We propose hardware techniques to virtualize the cores of a multicore processor, allowing hardware to flexibly reassign the virtual processors that are exposed, even to a single operating system, to any subset of the physical cores. We show that multicore virtualization operates with minimal overhead, and that it enables several novel resource management applications for improving both performance and reliability.
ChemInform Abstract: Solid‐State Conformations of Medium‐Sized‐Ring Phosphorus Heterocycles: X‐Ray Crystal Structures of Two Norbornene‐Fused 1,3,2‐Dioxaphosphepanes with Equatorially Disposed Substituents on Phosphorus. (1990)

Abstract The seven‐membered‐ring phosphorus heterocycles (Ia) (space group P2 1 /c, Z=4) and (Ib) (P2 1 2 1 2 1 , Z=4) are synthesized by equimolar reaction of 5‐norbornene‐endo,endo‐2,3‐dimethanol with phenyl dichlorophosphate or phenylphosphonic dichloride in the presence of NEt 3 as diastereomeric mixtures with their cis isomers and separated by preparative HPLC.
Carbon Bonding Determination with XES Using a TES Microcalorimeter Detector (2017)

Journal Article Carbon Bonding Determination with XES Using a TES Microcalorimeter Detector Get access George J Havrilla, George J Havrilla Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar Kathryn Mcintosh, Kathryn Mcintosh Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar Mark Croce, Mark Croce Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar Rachel Huber, Rachel Huber Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar David Podlesak, David Podlesak Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar Michael Rabin, Michael Rabin Los Alamos National Laboratory, New Mexico, USA Search for other works by this author on: Oxford Academic Google Scholar Fernando Vila, Fernando Vila University of Washington, Seattle, WA Search for other works by this author on: Oxford Academic Google Scholar Matthew Carpenter, Matthew Carpenter STAR Cryoelectronics, Santa Fe, NM Search for other works by this author on: Oxford Academic Google Scholar Robin Cantor Robin Cantor STAR Cryoelectronics, Santa Fe, NM Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 23, Issue S1, 1 July 2017, Pages 1060–1061, https://doi.org/10.1017/S1431927617005967 Published: 04 August 2017
Configurable emulated shared memory architecture for general purpose MP-SOCs and NOC regions (2009)

Emulated shared memory (ESM) multiprocessor systems on chip (MP-SOC) and network on chip (NOC) regions are efficient general purpose computing engines for future computers and embedded systems running applications unknown at the design phase. While they provide programmer a synchronous, unified, and constant time accessible shared memory, the existing ESM architectures have been shown to be inefficient with workloads having low parallelism. In this paper we outline a configurable emulated shared memory (CESM) architecture that retains the advantages of the ESM architectures for parallel enough code but is also able to execute applications with low parallelism efficiently. This happens by allowing multiple threads to join as a single nonuniform memory access (NUMA) bunch and organizing memory system to support NUMA-like behavior for thread-local data if parallelism is limited. Performance simulations as well as silicon area and power consumption estimations of CESM MP-SOC/ NOC regions are provided.
[Novel method for the synthesis of carboxamides from low reactivity esters: synthesis of 2-acylamino-1-benzothiophene-3-carboxamides]. (2008)

We planned and prepared a kinase inhibitor focused compound library around the 1-benzotiophene core structure, but the 2-acylamino-1-benzotiophene-3-carboxylic acid ethyl ester derivatives could not be converted to amides by the traditional methods like treatment with aqueous or alcoholic ammonia solution or ammonia gas. Under mild reaction conditions we have recovered the starting materials, higher temperature and pressure resulted the formation of pure ring-closed products. We have discovered a new method where the application of lithium amide in tetrahydrofurane resulted the desired compounds in acceptable yields (67-84%). The products were characterized thoroughly by spectral data, elementary analyses and melting points.
High throughput spatially sensitive single-shot quantitative phase microscopy (2020)

High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low coherence length light sources are generally implemented to achieve high spatial phase sensitivity in QPM at the cost of either reduced temporal resolution or smaller field of view (FOV). On the contrary, high temporal coherence light sources like lasers are capable of exploiting the full FOV of the QPM systems at the expense of less spatial phase sensitivity. In the present work, we employed pseudo-thermal light source (PTLS) in QPM which overcomes the limitations of conventional light sources. The capabilities of PTLS over conventional light sources are systematically studied and demonstrated on various test objects like USAF resolution chart and thin optical waveguide (height ~ 8 nm). The spatial phase sensitivity of QPM in case of PTLS is measured to be equivalent to that for white light source. The high-speed and large FOV capabilities of PTLS based QPM is demonstrated by high-speed imaging of live sperm cells that is limited by the camera speed and by imaging extra-ordinary large FOV phase imaging on histopathology placenta tissue samples.
Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides (2021)

Phosphorothioate-modified antisense oligonucleotide (PS-ASO) drugs are commonly used to modulate gene expression through RNase H1-mediated cleavage of target RNAs. Upon internalization through endocytic pathways into cells, PS-ASOs must be released from membraned endosomal organelles to act on target RNAs, a limiting step of PS-ASO activity. Here we report that Hsc70 protein mediates productive release of PS-ASOs from endosomes. Hsc70 protein was enriched in endosome fractions shortly after PS-ASO incubation with cells. Reduction of Hsc70 significantly decreased the activities of PS-ASOs in reducing target RNAs. PS-ASO uptake and transport from early endosomes to late endosomes (LEs) were not affected upon Hsc70 reduction; however, endosomal release of PS-ASOs was impaired. Reduction of Hsc70 led to more scattered mannose-6-phosphate receptor (M6PR) localization at LEs in the cytoplasm, in contrast to the perinuclear localization at <i>trans</i>-Golgi network (TGN) in control cells, suggesting that retrograde transport of M6PR from LEs to TGN was affected. Consistently, reduction of Hsc70 increased colocalization of M6PR and PS-ASOs at LEs, and also delayed M6PR antibody transport from LE to TGN. Together, these results suggest that Hsc70 protein is involved in M6PR vesicle escape from LEs and may thus enhance PS-ASO release from LEs.
Patents and Research in Spine Fusion and the Artificial Intervertebral Disc (2009)

This study evaluates spine fusion and artificial disc procedures, patents issued, and research articles to determine whether product innovation and research correlate with case-load. Principal spine fusion procedures were divided by International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) procedure codes using the Nationwide Inpatient Sample (NIS) for cervical, thoracic, and lumbar fusion (excluding reoperations), and artificial disc procedures. Patents were searched by year of issue through the United States Patent and Trademark Office. Research articles were searched by year of publication using the PubMed interface. Aggregate spinal fusion procedures increased by 162% from 1993–1999 to 2000–2006 (103 127 to 270 341 procedures per year, P < 0.0001), patents by 272% (33 to 122 patents per year, P < 0.0001), and research articles by 75% (442 to 773 articles per year, P < 0.001). Increases in fusion procedures and patent issues correlated strongly (r2 = 0.96), as did...
Enhanced performance of microfluidic soft pressure sensors with embedded solid microspheres (2016)

The cross-sectional geometry of an embedded microchannel influences the electromechanical response of a soft microfluidic sensor to applied surface pressure. When a pressure is exerted on the surface of the sensor deforming the soft structure, the cross-sectional area of the embedded channel filled with a conductive fluid decreases, increasing the channel's electrical resistance. This electromechanical coupling can be tuned by adding solid microspheres into the channel. In order to determine the influence of microspheres, we use both analytic and computational methods to predict the pressure responses of soft microfluidic sensors with two different channel cross-sections: a square and an equilateral triangular. The analytical models were derived from contact mechanics in which microspheres were regarded as spherical indenters, and finite element analysis (FEA) was used for simulation. For experimental validation, sensor samples with the two different channel cross-sections were prepared and tested. For comparison, the sensor samples were tested both with and without microspheres. All three results from the analytical models, the FEA simulations, and the experiments showed reasonable agreement confirming that the multi-material soft structure significantly improved its pressure response in terms of both linearity and sensitivity. The embedded solid particles enhanced the performance of soft sensors while maintaining their flexible and stretchable mechanical characteristic. We also provide analytical and experimental analyses of hysteresis of microfluidic soft sensors considering a resistive force to the shape recovery of the polymer structure by the embedded viscous fluid.
A state-of-charge uniformity control method for energy storage batteries based on distributed cooperative control (2021)

This paper proposes a state-of-charge equalization control strategy for energy storage battery modules based on distributed cooperative control. In the information layer, the energy storage module is regarded as an agent, and the state of charge (SOC) uniformity problem model is established by multi-agent system cooperative tracking. The distributed communication network between energy storage module modules is described by digraph. With the help of bounded S-like saturation function and based on the nearest neighbor principle, a bounded cooperative state of charge control law with adjustable control gain is designed. Assuming that the digraph contains spanning trees, the asymptotic stability of the whole closed-loop system is proved by Lyapunov Matrix Equation and LaSalle invariant principle. By adopting the method, the discharge of the energy storage module can be controlled based on distributed coordination, the charging state of the module can be synchronously reduced, and the service life and stability of the energy storage power station can be improved.
Modeling of a Methanol Synthesis Reactor for Storage of Renewable Energy and Conversion of CO2 – Comparison of Two Kinetic Models (2015)

Abstract The storage of renewable energy over a long time period, via methanol synthesis, will become very important to reach a greenhouse gas‐free energy supply. A steady‐state methanol synthesis flowsheet, containing a 2D pseudo‐homogeneous reactor, flash, and recycle, is modeled in MATLAB. With the kinetic models of Graaf and Bussche &amp; Froment, two frequently used kinetic models for conventional methanol synthesis are compared and evaluated for applicability regarding methanol synthesis from CO 2 /H 2 . The results are presented for different cases of synthesis gas compositions. Both kinetic models produce similar results when the system is limited by thermodynamic equilibrium. However, differences in reaction rates are observable from the reactor axial molar component profiles of the reaction products.