gebhart/patrepeval huggingface dataset:
Highlights from the Ninth International Congress on Molecular Plant–Microbe Interactions (1999)

The President of the International Society for Molecular Plant–Microbe Interactions (IS-MPMI), Barry Rolfe, wrote most insightfully in a recent online article about the importance of basic scholarship to the cultural integrity of modern civilized society (<http://www.scisoc.org/ismpmi/pubs/99spr.
A user-friendly method to geometrically calibrate projector-camera systems (2009)

Projector-camera systems drive applications in many fields such as measurement and spatial augmented reality. When needed, we can find their internal and external parameters via geometric calibration. For this process, we have to use both a printed pattern and a projector pattern, but they can easily interfere with each other. Current methods compensate by decoupling their calibrations or by leveraging structured light and color channels, but the required manipulations are not user-friendly. Therefore, we cannot expect normal users to execute the procedure, which can also become a burden for researchers. Although not always required, knowledge of the geometric parameters can often facilitate development of new systems. To make the calibration process easier, we propose a method that uses fiducial markers, from which we can easily derive a prewarp that, once applied to the projector calibration pattern, prevents its interference. Using our method, we confirmed that users can easily calibrate a projector-camera system in less than one minute, which we consider to be user-friendly, while still achieving typical subpixel accuracy.
Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity (2018)

Pancreatic tumor microenvironment is characterized by abundant fibrosis and aberrant vasculature. Aiming to reproduce in vitro these features, cancer cells have been already co-cultured with fibroblasts or endothelial cells separately but the integration of both these essential components of the pancreatic tumor microenvironment in a unique system, although urgently needed, was still missing. In this study, we successfully integrated cellular and acellular microenvironment components (i.e., fibroblasts, endothelial cells, fibronectin) in a hetero-type scaffold-free multicellular tumor spheroid. This new 3D triple co-culture model closely mimicked the resistance to treatments observed in vivo, resulting in a reduction of cancer cell sensitivity to the anticancer treatment.
Structural/functional properties of the Glu1‐HSer57 N‐terminal fragment of human plasminogen: Conformational characterization and interaction with kringle domains (1998)

The Glu1-Val79 N-terminal peptide (NTP) domain of human plasminogen (Pgn) is followed by a tandem array of five kringle (K) structures of approximately 9 kDa each. K1, K2, K4, and K5 contain each a lysine-binding site (LBS). Pgn was cleaved with CNBr and the Glul-HSer57 N-terminal fragment (CB-NTP) isolated. In addition, the Ile27-Ile56 peptide (L-NTP) that spans the doubly S-S bridged loop segment of NTP was synthesized. Pgn kringles were generated either by proteolytic fragmentation of Pgn (K4, K5) or via recombinant gene expression (rK1, rK2, and rK3). Interactions of CB-NTP with each of the Pgn kringles were monitored by 1H-NMR at 500 MHz and values for the equilibrium association constants (Ka) determined: rK1, Ka approximately 4.6 mM(-1); rK2, Ka approximately 3.3 mM(-1); K4, Ka approximately 6.2 mM-'; K5, K, 2.3 mM(-1). Thus, the lysine-binding kringles interact with CB-NTP more strongly than with Nalpha-acetyl-L-lysine methyl ester (Ka < 0.6 mM(-l), which reveals specificity for the NTP. In contrast, CB-NTP does not measurably interact with rK3. which is devoid of a LBS. CB-NTP and L-NTP 1H-NMR spectra were assigned and interproton distances estimated from 1H-1H Overhauser (NOESY) experiments. Structures of L-NTP and the Glul-Ile27 segment of CB-NTP were computed via restrained dynamic simulated annealing/energy minimization (SA/EM) protocols. Conformational models of CB-NTP were generated by joining the two (sub)structures followed by a round of constrained SA/EM. Helical turns are indicated for segments 6-9, 12-16, 28-30, and 45-48. Within the Cys34-Cys42 loop of L-NTP, the structure of the Glu-Glu-Asp-Glu-Glu39 segment appears to be relatively less defined, as is the case for the stretch containing Lys5O within the Cys42-Cys54 segment, consistent with the latter possibly interacting with kringle domains in intact Glul-Pgn. Overall, the CB-NTP and L-NTP fragments are of low regular secondary structure content-as indicated by UV-CD spectra- and exhibit fast amide 1H-2H exchange in 2H2O, suggestive of high flexibility.
Accuracy of alcohol and breast cancer risk information on Drinkaware’s website (2018)

A recent paper in Drug and Alcohol Review analysed the information on cancer disseminated by 27 alcohol industry funded organisations. The independent UK alcohol education charity Drinkaware was among the organisations whose information was studied, and based on the analysis claims were made of misrepresentation of evidence about the alcohol-related risk of cancer and alcohol industry influence. This commentary challenges the validity of these findings in respect to the evidence relating to the Drinkaware information, as the analysis is found to be misrepresenting the information by both disregarding the wider information content provided and the order and prominence with which alcohol-related cancer risk is presented. Furthermore, it is argued that the public has a right to be provided with relevant evidence-based information about cancer risk. It is critical that Drinkaware's important public health function is not compromised by unjustified allegations of inaccuracy and by unwarranted attacks on its independence and integrity.
Gemma: A Sandia National Laboratories Electromagnetic Code for Heterogeneous Computer Architectures. (2021)

Abstract not provided.
Dynamics in nonlinear optical polymers (2003)

Abstract This work concerns theoretical and experimental investigations of dynamics in nonlinear optical polymers. Polymers attract considerable attention in search for new optical materials due to low cost, ease of fabrication, and the possibility of designing specific optical properties. In this project emphasis is placed on the dynamics of dipolar molecules embedded in a polymer host. Two main topics are examined: (i) the effect of rotational diffusion of nonlinear optical chromophores in AC biased photorefractive polymers. The rotational mobility of chromophores introduces new criteria for AC field enhancement and the specific requirements concerning orientational enhancement are determined using the oriented gas model; (ii) the coupling between the nonlinear optical chromophore and the polymer matrix. The strict topological constraints in solid polymers imply a viscoelastic response to chromophore reorientation. A novel theory based on a local molecular field at the chromophore site, is developed. The dynamics induced by a combined AC and DC applied poling field is considered in the rotational diffusion picture, and the analytical expressions for the
Design, Synthesis, and Action of Oxotremorine-Related Hybrid-Type Allosteric Modulators of Muscarinic Acetylcholine Receptors (2005)

A novel series of muscarinic receptor ligands of the hexamethonio-type was prepared which contained, on one side, the phthalimidopropane or 1,8-naphthalimido-2,2-dimethylpropane moiety typical for subtype selective allosteric antagonists and, on the other, the acetylenic fragment typical for the nonselective orthosteric muscarinic agonists oxotremorine, oxotremorine-M, and related muscarinic agonists. Binding experiments in M(2) receptors using [(3)H]N-methylscopolamine as an orthosteric probe proved an allosteric action of both groups of hybrids, 7a-10a and 8b-10b. The difference in activity between a-group and b-group hybrids corresponded with the activity difference between the allosteric parent compounds. In M(1)-M(3) muscarinic isolated organ preparations, most of the hybrids behaved as subtype selective antagonists. [(35)S]GTPgammaS binding assays using human M(2) receptors overexpressed in CHO cells revealed that a weak intrinsic efficacy was preserved in 8b-10b. Thus, attaching muscarinic allosteric antagonist moieties to orthosteric muscarinic agonists may lead to hybrid compounds in which functions of both components are mixed.
Sub‐Micrometer Surface‐Patterned Ribbon Fibers and Textiles (2017)

The worldwide annual production volume of textiles is nearly one hundred million metric tons. Most of these undergo treatments to achieve specific properties, such as color, hydrophobicity, antimicrobial, or UV protection, using chemicals that lead to collateral environmental consequences. There is great interest in developing alternative and sustainable strategies to achieve textile functionality that do not involve chemical treatment. Here we present a thermal drawing approach to achieve fiber surface gratings on a rectangular cross-section. We demonstrate directional wetting properties as well as structural coloration based on the gratings. Periods down to ≈ 600 nm were established on the surface of a fiber. Fabrics displaying higher-order diffraction peaks in the visible regime were produced from surface-patterned fibers using convetional weaving machinery.
Efficient and General Protocol for the Copper-Free Sonogashira Coupling of Aryl Bromides at Room Temperature (2003)

[reaction: see text]. A mild and general protocol for the copper-free Sonogashira coupling of aryl bromides with acetylenes has been developed. The use of (AllylPdCl)2 and P(t-Bu)3 provides the active Pd(0) catalyst that allows subsequent coupling of various alkynes at room temperature with good to excellent yields.
The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial (2021)

Abstract Purpose The aim of the study was to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow‐up. Design This is a randomized, two‐centre, prospective open‐labelled treatment trial for open‐angle glaucoma (OAG). Participants The participants of this study were treatment‐naive patients with newly diagnosed OAG, aged 46–78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study. Methods Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in treatment were allowed. Standard automated perimetry and tonometry were performed and side‐effects documented. All results are presented using intention‐to‐treat analysis. Results A total of 242 patients were randomized. After 3 years of follow‐up, eight patients were lost to follow‐up, six of whom were deceased. The median untreated baseline intraocular pressure (IOP) was 24 mmHg in both arms. The median IOP was almost constant over the 3 years of follow‐up: ≈17 mmHg in the mono‐arm and ≈14 mmHg in the multi‐treatment arm. Treatment was intensified in 42% of the mono‐treated patients and in 7% of the multi‐treated patients. Treatment was reduced in 13% of the multi‐treated patients. The median perimetric rate of progression was −0.5%/year in the mono‐treated group and −0.1%/year in the multi‐treated group (p = 0.03). Conclusion The rate of disease progression was significantly slower in the multi‐treated patients than in the mono‐treated patients. Further follow‐up will show whether this difference is sustained over time.
Inhibition of barosensitive neurones evoked by lobule IXb of the posterior cerebellar cortex in the decerebrate rabbit. (1990)

1. Electrical stimulation of lobule IXb of the posterior cerebellar vermis evoked an increase in heart rate and arterial pressure in the decerebrate rabbit. This pattern of response was followed by a rebound bradycardia which was maintained until arterial pressure had returned to control levels. Activation of the arterial baroreceptors during IXb stimulation failed to elicit reflex changes in heart rate and arterial blood pressure. 2. Extracellular recordings were made from eighty-one single neurones in the nucleus tractus solitarius (NTS), and adjacent structures, that received inputs from the carotid sinus nerve, aortic nerve and/or vagus. A proportion of these were characterized as baro- or chemosensitive by physiological stimuli. The nature of the input from lobule IXb onto these cells was studied subsequently. 3. In twenty-seven out of thirty-five barosensitive neurones, stimulation of lobule IXb either decreased or abolished on-going activity. The latency to onset of inhibition was 21 ms in fourteen cells. In a further twenty-one neurones the spikes evoked orthodromically by electrical stimulation of either the aortic or sinus nerves were either inhibited or severely reduced in number during short-train conditioning stimulation of lobule IXb. This effect was most potent when the cortical conditioning stimulus was timed to occur 25 ms before the aortic or carotid sinus nerves were stimulated. 4. It is suggested that stimulation of lobule IXb in the decerebrate rabbit expresses its influence on the cardiovascular system in part by an inhibitory action on neurones receiving baroreceptor inputs at the level of the NTS.
Clinical complete long-term remission of a patient with metastatic malignant melanoma under therapy with indisulam (E7070) (2007)

The objective of this study is to report on long-term survival of a patient with metastatic melanoma treated with indisulam showing a distinct genetic pattern of repression of subsets of genes involved in mitochondrial energy metabolism. Gene expression profiling was performed with oligonucleotide microarray analysis. A 45-year-old patient with metastatic malignant melanoma was treated in third-line with indisulam (goal, E7070), a new chloroindolyl-sulphonamide cell-cycle inhibitor. The patient was treated weekly with a dose of 40 mg/m within a phase I study. On the basis of an amendment, the dose was escalated to 320 mg/m at maximum and de-escalated to 160 mg/m for long-term application in this individual patient. At the start of treatment the tumour burden consisted of two-in-transit-metastases, two further skin lesions, two cervical lymph nodes and four pulmonary metastases. Under a 2.5-year treatment with indisulam the tumour shrunk markedly although the objective response only reached stable disease. Lymph node biopsy revealed absence of vital melanoma cells. Therapy was stopped upon request of the patient. The gene expression profile indicated a profound transcriptional repression of subsets of genes involved in mitochondrial energy metabolism; namely NDUFB8, NDUFS1, NDUFV1, ACADVL and Homo sapiens clone 24408. The survival of this patient with metastatic melanoma lasted now 9 years, the progression-free interval 105 months. It can be assumed that this treatment effect is attributed to the down-regulating effect of indisulam on metabolic genes involved in energy production. Thus, knowledge on individual's tumour gene regulation may predict sensitivity and resistance to antitumoural agents.
Caroviologen molecular wires: pulse radiolysis of bis(pyridinium) polyenes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCaroviologen molecular wires: pulse radiolysis of bis(pyridinium) polyenesAnny Slama-Schwok, Mireille Blanchard-Desce, and Jean Marie LehnCite this: J. Phys. Chem. 1992, 96, 25, 10559–10565Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/j100204a079https://doi.org/10.1021/j100204a079research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
ChemInform Abstract: Peptide Conformation: Stability and Dynamics (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Retransformed graphitic activated carbon from ionic liquid-derived carbon containing nitrogen (2015)

Carbonization and chemical activation of an ionic liquid are demonstrated to produce an outstanding structural combination of an unexpectedly high surface area and a graphitic structure.
3D-aware image editing for out of bounds photography (2009)

Figure 1: Example “Out of Bounds images ” obtained with our software tool. The algorithms presented in this paper allow a user to easily create such depth-rich images starting from single, conventional two-dimensional photographs and paintings. The careful placement of occlusions and cast shadows is responsible for the strong “pop-out ” effect in these images. In this paper, we propose algorithms to manipulate 2D images in a way that is consistent with the 3D geometry of the scene that they capture. We present these algorithms in the context of creating “Out of Bounds”(OOB) images- compelling, depth-rich images generated from single, conventional 2D photographs (fig. 1). Starting from a single image our tool enables rapid OOB prototyping; i.e. the ability to quickly create and experiment with many different variants of the OOB effect before deciding which one best expresses the users ’ artistic intentions. We achieve this with a flexible work-flow driven by an intuitive user interface. The rich 3D perception of the final composition is achieved by exploiting
Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade (2020)

Our findings suggest that some chemotherapies may impair the anti-tumor efficacy of immunotherapy. Further studies are required to uncover the specific effects of different chemotherapies on the immunological profile of tumors. This data will be critical for the rational design of combination immunotherapy strategies for patients with hepatocellular carcinoma.
Gradient tracking and variance reduction for decentralized optimization and machine learning (2020)

Decentralized methods to solve finite-sum minimization problems are important in many signal processing and machine learning tasks where the data is distributed over a network of nodes and raw data sharing is not permitted due to privacy and/or resource constraints. In this article, we review decentralized stochastic first-order methods and provide a unified algorithmic framework that combines variance-reduction with gradient tracking to achieve both robust performance and fast convergence. We provide explicit theoretical guarantees of the corresponding methods when the objective functions are smooth and strongly-convex, and show their applicability to non-convex problems via numerical experiments. Throughout the article, we provide intuitive illustrations of the main technical ideas by casting appropriate tradeoffs and comparisons among the methods of interest and by highlighting applications to decentralized training of machine learning models.
The Role of lnterleukin-4 in Normal and Malignant Human Hematopoiesis (2020)

Interleukin 4 (IL-4) was identified in 1982 for its ability to induce the proliferation of murine B lymphocytes costimulated with anti-IgM and for its capacity to induce lipopolysaccharide (LPS)-activated B cells to produce IgG1. The signaling mechanisms through the IL-4 receptor has recently been reviewed. Cross-linking studies have shown that the p140 chain of the IL-4 receptor associates with the common yc-chain following binding of IL-4, suggesting that such heterodimerization is important for biological activity. Murine fibroblastic bone marrow stromal cells can produce IL-4 constitutively, and this function is up-regulated by exposure to IL-1. Interleukin-4 enhances the antigen-presenting capacity of monocytes-macrophages through an increased expression of major histocompatibility complex class II molecules, and down-regulates expression of the differentiation antigen CD 14, a receptor for LPS. Interleukin-4 in combination with erythropoietin supports the development of small numbers of erythroid-mixed colonies from murine bone marrow.
Abstract 1810: PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity (2014)

Abstract Non-covalent proteasome inhibitors that are less toxic and more effective against solid tumors than currently used proteasome inhibitors are desirable. Through HTS and hit-to-lead optimization efforts we have identified PI-1840, a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over T-L and PGPH (IC50 values &amp;gt;100 µM) activities of the proteasome. Furthermore, PI-1840 is over 100-fold more selective for the constitutive proteasome over the immunoproteasome. Dialysis and mass spectrometry studies demonstrate that PI-1840 is a non-covalent and rapidly reversible CT-L inhibitor. PI-1840 inhibits CT-L activity, induces the accumulation of proteasome substrates p27, Bax and IκB-α, inhibits survival pathways and proliferation, and induces apoptosis in human cancer cells. The mdm2/p53 disruptor, nutlin, sensitizes cancer cells to PI-1840 in a p53-dependent manner. Furthermore, the pan Bcl-2 antagonist BH3-M6 also sensitizes cancer cells to PI-1840. Finally, in vivo, PI-1840 but not Bortezomib (clinically used proteasome inhibitor) suppresses the growth in nude mice of human breast xenografts. These results warrant further evaluation of non-covalent and rapidly reversible proteasome inhibitor as potential anticancer agents against solid tumors. Citation Format: Said M. Sebti, Aslamuzzaman Kazi, Sevil Ozcan, Awet G. Tecleab, Ying Sun, Harshani Lawrence. PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1810. doi:10.1158/1538-7445.AM2014-1810