gebhart/patrepeval huggingface dataset:
Supplementary movie 2 from Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth (2023)

&lt;p&gt;Effect of SBI-581 on TKS5alpha vesicle trafficking&lt;/p&gt;
Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study (2020)

Anonymized summary data may be requested from the corresponding author.
AN EXPERIMENTAL, NUMERICAL, AND CFD INVESTIGATION INTO THE HEAT TRANSFER AND FLOW CHARACTERISTICS IN POROUS MEDIA USING A THERMAL NON-EQUILIBRIUM MODEL (2006)

Abstract : Heat transfer and fluid flow through porous media was investigated using numerical simulations and experiment. For the numerical simulations, two models were created. The first consisted of a two-dimensional numerical model created in MathCAD and was solved using the finite difference approach. The MathCAD model's flow in the porous media was described by the Brinkman-Forchheimer-extended Darcy equation. The second model consisted of a computational fluid dynamics (CFD) porous media model using Fluent and was solved using the finite volume approach. Both models assumed constant fluid phase and properties. Pore diameters were held constant for each simulation; two different porosities were investigated. Boundary conditions were applied at the wall in which the temperatures of the fluid and the porous media were determined by coupled energy equations. The effects of the boundary condition, the Reynolds number, porosity, and heat input were examined.
Using multiple image planes to achieve near-correct focus cues in a 3d display (2004)

Conventional digital displays present stimuli at only one focal distance because the light comes from a single surface. When the display is meant to create a 3d percept, two significant problems occur. First, depth information from accommodation and the blur gradient is uncontrolled, which can lead to distortions in perceived 3d structure. Second, observers often experience discomfort and have difficulty fusing the two eyes' images because of the decoupling of vergence and accommodation. We devised and implemented a display technique that uses multiple image planes to present stereoscopic stimuli at near-correct focal distances. Each eye's view is the sum of several images, each presented at a different focal distance. Parts of the scene at “intermediate distances” (i.e., between the image planes) are displayed by distributing the image intensity, along lines of sight, across two or more image planes. Experiments showed that the display was effective in reducing problems caused by the accommodation-vergence mismatch. Compared to a fixed display distance, observers required less time to fuse a random-dot stereogram presented at different distances, including distances between the image planes. Stereoscopic depth constancy was also improved. Observers reported, however, that a slanted textured plane viewed monocularly did not look planar. This finding is understandable because focus cues should be given more weight in the absence of disparity signals, and at distances between the image planes, the blur gradient in our display differs significantly from that created by a real slanted plane. Our experiments provide further evidence that depth percepts are affected by focus cues. We conclude that the multiple-planes approach provides a practical solution to some of the problems created by conventional displays.
Trainable Automatic Text Summarization Using Segmentation of Sentence (2002)

method combining conventional sentence extraction and trainable classifier based on Support Vector Machine. To make extraction unit smaller than the original sentence extraction, we also introduce sentence segmentation process in our method. The evaluation results show that our system achieves the best result among all the other systems with regard to contents, and closer to the human constructed summaries (upper bound) at 20% summary rate. On the other hand, the system needs to improve readability of its summary output.
Thesen (2015)

Das Buch beschäftigt sich mit verfassungs- und europarechtlichen Aspekten eines allgemeinen Mindestlohns. Der Ansatz ist interdisziplinär und bezieht auch andere sozialwissenschaftliche, insbesondere ökonomische Erwägungen ein. Neben den Freiheitsrechten des Europarechts und des Grundgesetzes wird der Mindestlohn auch in gleichheitsrechtlicher Perspektive betrachtet. Als „internalisierendes Sozialrecht“ dient er der Existenzsicherung der Arbeitnehmer. Aber belastet werden für dieses gesamtgesellschaftliche Ziel nur die Arbeitgeber. Weil die denkbaren Rechtfertigungen für diese Ungleichbehandlung im Ergebnis nicht überzeugen, ist der Mindestlohn verfassungswidrig. Der Gesetzgeber wäre auf Transferzahlungen zur Aufstockung nicht bedarfssichernder Arbeitsentgelte verwiesen. Den Abschluss bildet ein Blick auf alternative Modelle, insbesondere Kombilöhne nach Muster des US-amerikanischen Earned Income Tax Credit.
Semidefinite Programming for Community Detection With Side Information (2021)

This paper produces an efficient semidefinite programming (SDP) solution for community detection that incorporates non-graph data, which in this context is known as side information. SDP is an efficient solution for standard community detection on graphs. We formulate a semi-definite relaxation for the maximum likelihood estimation of node labels, subject to observing both graph and non-graph data. This formulation is distinct from the SDP solution of standard community detection, but maintains its desirable properties. We calculate the exact recovery threshold for three types of non-graph information, which in this paper are called side information: partially revealed labels, noisy labels, as well as multiple observations (features) per node with arbitrary but finite cardinality. We find that SDP has the same exact recovery threshold in the presence of side information as maximum likelihood with side information. Thus, the methods developed herein are computationally efficient as well as asymptotically accurate for the solution of community detection in the presence of side information. Simulations show that the asymptotic results of this paper can also shed light on the performance of SDP for graphs of modest size.
Crack depth profiling using guided wave angle dependent reflectivity (2015)

Tomographic corrosion monitoring techniques have been developed, using two rings of sensors around the circumference of a pipe. This technique is capable of providing a detailed wall thickness map, however this might not be the only type of structural damage. Therefore this concept is expanded to detect and size cracks and small corrosion defects like root corrosion. The expanded concept uses two arrays of guided-wave transducers, collecting both reflection and transmission data. The data is processed such that the angle-dependent reflectivity is obtained without using a baseline signal of a defect-free situation. The angle-dependent reflectivity is the input of an inversion scheme that calculates a crack depth profile. From this profile, the depth and length of the crack can be determined. Preliminary experiments show encouraging results. The depth sizing accuracy is in the order of 0.5 mm.
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells (2017)

Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymerase 1 (PARP1) serve as backups. Here we have designed a personalized medicine approach called gene expression and mutation analysis (GEMA) to identify BRCA- and DNA-PK-deficient leukemias either directly, using reverse transcription-quantitative PCR, microarrays, and flow cytometry, or indirectly, by the presence of oncogenes such as BCR-ABL1. DNA-PK-deficient quiescent leukemia cells and BRCA/DNA-PK-deficient proliferating leukemia cells were sensitive to PARP1 inhibitors that were administered alone or in combination with current antileukemic drugs. In conclusion, GEMA-guided targeting of PARP1 resulted in dual cellular synthetic lethality in quiescent and proliferating immature leukemia cells, and is thus a potential approach to eradicate leukemia stem and progenitor cells that are responsible for initiation and manifestation of the disease. Further, an analysis of The Cancer Genome Atlas database indicated that this personalized medicine approach could also be applied to treat numerous solid tumors from individual patients.
Low-jitter semiconductor modelocked laser module utilizing packaged low-capacitance gain elements (2003)

Fiber-pigtailed low-capacitance semiconductor gain elements were developed and utilized within a harmonically modelocked sigma-cavity to produce a low-jitter picosecond pulse source. The use of an intra-cavity etalon filter suppressed supermode spurs.
Aqueous Transport Properties of Mesoporous .gamma.-Al2O3 Membranes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAqueous Transport Properties of Mesoporous .gamma.-Al2O3 MembranesJames R. Miller and William J. KorosCite this: Ind. Eng. Chem. Res. 1994, 33, 4, 934–941Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ie00028a022https://doi.org/10.1021/ie00028a022research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epidermal Growth Factor Stimulates Tissue Plasminogen Activator Activity and Messenger Ribonucleic Acid Levels in Cultured Rat Granulosa Cells: Mediation by Pathways Independent of Protein Kinases-A and -C* (1989)

Recent reports suggest that epidermal growth factor (EGF) or related peptides may act as local hormones to regulate granulosa cell differentiation. While FSH and GnRH are known to stimulate accumulation of tissue-type plasminogen activator (tPA) mRNA in granulosa cells, studies using nonovarian cells have shown stimulation of tPA by EGF. In this study, the effect of EGF and its structural analog transforming growth factor-alpha (TGF alpha) on ovarian tPA mRNA and activity was investigated. Granulosa cells obtained from immature estrogen-treated rats were cultured with FSH or increasing doses of EGF or TGF alpha before analysis of tPA activity using sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by a fibrin overlay technique. Like FSH and GnRH, EGF and TGF alpha stimulated the secretion of tPA activity in a dose- and time-dependent manner (onset, 12 h; maximum, 48 h). Northern blot hybridization of total RNA using a rat cRNA probe for tPA showed the accumulation of a 22S species mRNA in cells treated with EGF or TGF alpha, but not with nerve growth factor, suggesting increased expression of the tPA gene. Furthermore, slot blot hybridization of RNA from these cells confirmed a time-dependent increase in tPA mRNA preceding that in enzyme activity. Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels. In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway. Suppression of protein synthesis by cycloheximide inhibited the induction of tPA mRNA by EGF, whereas similar treatment resulted in the superinduction of tPA mRNA in FSH-treated cells, suggesting that EGF and FSH do not share the same pathway. These results suggest that EGF and TGF alpha induce tPA mRNA and activity in granulosa cells through a pathway independent of protein kinases-A (FSH) and -C (GnRH and phorbol ester), providing an interesting model for future elucidation of the molecular mechanism involved in tPA gene expression.
Biochemical considerations in 1H spectroscopy. Glutamate and glutamine; Myo‐inositol and related metabolites (1991)

Glutamate and glutamine, which can be clearly identified and, in part, quantified in proton spectra of the brain, play important roles in normal and pathological biochemistry. Pathways of glutamate metabolism include transamination, dehydrogenation, deamination and decarboxylation (to GABA). Glutamine is notable in hepatic encephalopathy, but is also a significant metabolic fuel in several other organs and tissues, including neoplasms. Myo-inositol is a 6-carbon alcohol which acquires new interest from its detection and quantitation in 1H spectra. Its role, apart from a biochemical relationship to messenger-inositol polyphosphates, is unclear.
Plasmon-enhanced photocurrent in quasi-solid-state dye-sensitized solar cells by the inclusion of gold/silica core–shell nanoparticles in a TiO2 photoanode (2013)

Direct evidence of the effects of the localized surface plasmon resonance (LSPR) of gold nanoparticles (Au NPs) in TiO2 photoanodes on the performance enhancement in quasi-solid-state dye-sensitized solar cells (DSCs) is reported by comparing gold/silica core–shell nanoparticles (Au@SiO2 NPs) and hollow silica nanoparticles with the same shell size of the core–shell nanoparticles. The Au nanoparticles were shelled by a thin SiO2 layer to produce the core–shell structure, and the SiO2 hollow spheres were made by dissolving the Au cores of the gold/silica core–shell nanoparticles. Therefore, the size and morphology of the SiO2 hollow spheres were the same as the Au@SiO2 NPs. The energy conversion efficiency was improved nearly 36% upon incorporating the Au nanoparticles, mostly due to the increase in Jsc, while Voc and FF were unchanged. The improvement was mostly contributed by the LSPR of the Au@SiO2 NPs, whereas the other parameters, such as the electron lifetime and electron diffusion coefficient, were nearly unchanged. Therefore, LSPR is an effective tool in improving the photocurrent and consequently the performance of DSCs.
Characteristics of Organic Transformations in a Confined Dendritic Core: Studies on the AIBN‐Initiated Reaction of Dendrimer Cobalt(II) Porphyrins with Alkynes (2003)

Cobalt(II) complexes of poly(aryl ester) dendrimer porphyrins [(m-[Gn]TPP)Co(II)] (generation number n=0-4), in the presence of azobisisobutyronitrile (AIBN) at 60 degrees C, underwent alkenylation with several alkynes at the metal center. A complete inhibition of double-bond migration (secondary transformation) was observed for [(m-[Gn]TPP)Co(II)] (n=3 and 4), which gave [(m-[Gn]TPP)Co(III)-C(=CH(2))R] (n=3 and 4) exclusively. Overall reaction rates for [(m-[Gn]TPP)Co(II)] (n=0-3) were hardly dependent on the size of the dendritic substituents, while a notable retardation was observed for the largest dendrimer, [(m-[G4]TPP)Co(II)]. Mechanistic studies on double-bond migration with pure [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=0-4) demonstrated that the secondary transformation involves participation of [(m-[Gn]TPP)Co(III)H] (n=0-4), derived from [(m-[Gn]TPP)Co(II)] and AIBN, rather than [(m-[Gn]TPP)Co(II)] alone. Crossover experiments using [(m-[Gn]TPP)Co(III)-C(=CH(2))Bu] (n=2-4), in combination with nondendritic [(m-[G0]TPP)Co(II)] and AIBN, indicated a high level of steric protection of the active center by a robust [G4]-dendritic cage, as suggested by a (1)H NMR pulse relaxation time profile of m-[G4]TPPH(2).
Open Reduction and Internal Fixation of Radial Head Fractures: Do Outcomes Differ Between Simple and Complex Injuries? (2014)

Level III, therapeutic study. See Instructions for Authors for a complete description of levels of evidence.
Research recommendations toward a better understanding of the causes of childhood leukemia (2011)

6 páginas.-- Meeting report.-- This work is licensed under the Creative Commons&#13;\nAttribution-NonCommercial-No Derivative Works&#13;\n3.0 Unported License.&#13;\n.-- et al.
Copper-catalyzed,N-auxiliary group-controlled switchable transannulation/nitration initiated by nitro radicals: selective synthesis of pyridoquinazolones and 3-nitroindoles (2021)

Within the scope of nitration reactions, the efficiency of sensitive heteroaromatics such as indoles is often eroded by various competitive oxidative decomposition pathways.
829 Numerical analysis of arterial pressure waveforms under various physiological conditions with a multi-scale model of the human cardiovascular system (2008)

A multi-scale computational model of the cardiovascular system is developed for the purpose of studying the changes in arterial pulses with physiological condition. In this study, we play emphasis on heartbeat rate, one of the parameters most sensitive to physiological condition. Herein, three heartbeat rate cases (40, 60 and 120 beats/minute) are studied. Obtained results show pronounced changes in both the shape and the magnitude of arterial pulses with heartbeat rate. Such changes are attributable to the dependence of systolic wave reflection on systolic duration determined by heartbeat rate. These findings indicate that the effects of heartbeat should be considered carefully when analyzing measured arterial pulses, otherwise, wrong conclusions might be drawn.
LOWER CALICEAL STONE CLEARANCE AFTER SHOCK WAVE LITHOTRIPSY OR URETEROSCOPY: THE IMPACT OF LOWER POLE RADIOGRAPHIC ANATOMY (1998)

The 3 major radiographic features of the lower pole calix (infundibulopelvic angle, and infundibular length and width) can be easily measured on standard IVP using a ruler and protractor. Each factor individually has a statistically significant influence on stone clearance after ESWL. A wide infundibulopelvic angle or short infundibular length and broad infundibular width regardless of infundibulopelvic angle are significant favorable factors for stone clearance following ESWL. Conversely, these factors have a cumulatively negative effect on the stone clearance rate after ESWL when they are all unfavorable. In ureteroscopy spatial anatomy has less of a role in regard to stone clearance but it may have a negative impact when there is uniformly unfavorable anatomy.
Detecting traffic anomalies using an equilibrium property (2010)

When many flows are multiplexed on a non-saturated link, their volume changes over short timescales tend to cancel each other out, making the average change across flows close to zero. This equilibrium property holds if the flows are nearly independent, and it is violated by traffic changes caused by several correlated flows. We exploit this empirical property to design a computationally simple anomaly detection method.
Safety analysis of endoscopist‐directed propofol sedation: A prospective, national multicenter study of 24 441 patients in German outpatient practices (2013)

Four years after the implementation of a German S3-Guideline for endoscopic sedation, we demonstrated that EDP is a safe procedure.
Classification of lubricants for PVC by compaction testing (1982)

Abstract Compaction testing was used to classify 10 lubricants for PVC, spanning the range of chemical types. Lubricants are defined as internal or external by their effect on compaction on being added to a standard base formulation. The results show excellent correlation by chemical type, in which the lubricants are divided into three distinct categories—external lubricants: paraffin waxes and low‐density polyethylenes; intermediate lubricants: montanic ester waxes and bisstearmides; internal lubricants: glycerol and monostearate and fatty acid alcohols. A test is proposed by which new additives may be easily classified or present lubricant systems evaluated.
The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking (2019)

Receptor-transporting protein 1S (RTP1S) is an accessory protein that mediates the transport of mammalian odorant receptors (ORs) into the plasma membrane. Although most ORs fail to localize to the cell surface when expressed alone in nonolfactory cells, functional expression of ORs is achieved with the coexpression of RTP1S. However, the mechanism for RTP1S-mediated OR trafficking remains unclear. In this study, we attempted to reveal the mode of action and critical residues of RTP1S in OR trafficking. Experiments using N-terminal truncation and Ala substitution mutants of RTP1S demonstrated that four N-terminal amino acids have essential roles in OR trafficking. Additionally, using recombinant proteins and split luciferase assays in mammalian cells, we provided evidence for the dimer formation of RTP1S. Furthermore, we determined that the 2nd Cys residue is required for the efficient dimerization of RTP1S. Altogether, these findings provide insights into the mechanism for plasma membrane transport of ORs by RTP1S.
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A (2020)

Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores-a zinc binding group and a Cys-reactive warhead-were designed to leverage both affinity and reactivity. A series of first-generation bifunctional inhibitors was achieved through structure-based inhibitor design. Through X-ray crystallography, engagement of both the catalytic Zn<sup>2+</sup> and Cys165 was confirmed. A second-generation series improved on affinity by incorporating known reversible inhibitor pharmacophores; the mechanism was confirmed by exhaustive dialysis, mass spectrometry, and <i>in vitro</i> evaluation against the C165S mutant. Finally, a third-generation inhibitor was shown to have good cellular activity and low toxicity. In addition to our findings, an alternative method of modeling time-dependent inhibition that simplifies assay setup and allows comparison of inhibition models is discussed.
Integrated modeling of transition scenarios towards climate-smart agriculture based on agro-ecology and territorial bio-economy (2019)

International audience
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating. (2012)

Abstract A wide range of arylated heteroaryls and bisheteroaryls can be prepared in good to high yields.