gebhart/patrepeval huggingface dataset:
Synthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages (1997)

Abstract Mixed backbone oligonucleotides (MBOs) (containing ionic and non-ionic internucleotidic linkages) in which the non-ionic segments are either methylphosphotriester (PO-OMe) or primary phosphoramidate (PO-NH2) linkages have been prepared using the recently described N-pent-4-enoyl (PNT) nucleoside phosphoramidates and H-phosphonates. Biophysical properties and stability studies suggest that these MBOs are novel antisense molecules.
Infection with fatal outcome after endovascular metallic stent placement. (1994)

The authors describe a case in which infection developed in a patient after placement of a metallic endoprosthesis in the iliac artery. The patient died of respiratory failure secondary to sepsis. Imaging studies did not reveal an abscess, aneurysm, or stent occlusion. Stent cultures and hemocultures grew Staphylococcus aureus. As with any foreign body, infectious complications may occur after insertion of metallic stents and should be recognized as soon as possible to initiate appropriate therapy.
α4/3 Conotoxins: phylogenetic distribution, functional properties, and structure–function insights (2007)

This review examines the alpha4/3 conotoxins as an example of molecular diversity in a class of compounds that have evolved in a group of closely related species in a single phylogenetic lineage. The species examined belong to Stephanoconus, a clade of Conus, a genus that contains 500-700 different species of carnivorous marine snails. We examine earlier work that describes the identification and characterization of alpha-ImI, the founding alpha4/3 toxin, and two other alpha4/3 toxins, alpha-ImII and alpha-RgIA. These three toxins all inhibit nicotinic acetylcholine receptors (nAChRs) belonging to a subset of nAChRs that are composed of only alpha subunits; they are, however, diverse in terms of the all-alpha subtype they preferentially antagonize and the receptor site that they bind to. We thus speculate that the alpha4/3 toxins may be a rich source of functionally diverse all-alpha subunit nAChR inhibitors. We review extensive work that has established a detailed model for alpha-ImI binding to one of its preferred nAChR subtypes (the alpha7 nAChR) and, by comparing the alpha-ImI, alpha-ImII and alpha-RgIA sequences demonstrate how structural features of alpha4/3 peptides that account for their diverse functional properties can be identified. This approach is extended to derive models of receptor-toxin binding that may account for the different subtype specificities of alpha4/3 peptides. We also speculate on how rational modification of alpha4/3 toxins may allow engineering of ligands with desired subtype specificities. The chemical diversity produced by the closely related animals in Stephanoconus is thus functionally differentiated, although structurally homologous.
Superlattice photonic crystal as broadband solar absorber for high temperature operation (2014)

A high performance solar absorber using a 2D tantalum superlattice photonic crystal (PhC) is proposed and its design is optimized for high-temperature energy conversion. In contrast to the simple lattice PhC, which is limited by diffraction in the short wavelength range, the superlattice PhC achieves solar absorption over broadband spectral range due to the contribution from two superposed lattices with different cavity radii. The superlattice PhC geometry is tailored to achieve maximum thermal transfer efficiency for a low concentration system of 250 suns at 1500 K reaching 85.0% solar absorptivity. In the high concentration case of 1000 suns, the superlattice PhC absorber achieves a solar absorptivity of 96.2% and a thermal transfer efficiency of 82.9% at 1500 K, amounting to an improvement of 10% and 5%, respectively, versus the simple square lattice PhC absorber. In addition, the performance of the superlattice PhC absorber is studied in a solar thermophotovoltaic system which is optimized to minimize absorber re-emission by reducing the absorber-to-emitter area ratio and using a highly reflective silver aperture.
The damage of skeletal muscles due to A (H1N1v) virus (2013)

Introduction. The feature of the A (H1N1v) virus infection is the development of rhabdomyolysis of skeletal muscles, accompanied by increased levels of creatine kinase (CK), lactate dehydrogenase (LDH) and myoglobin of blood. [Carrillo-Esper R. Gac. Med. Mex. 2009; 45: 519-521]. Rhabdomyolysis leads to aggravation of respiratory failure (RF) and hypoxemia. Aims and objectives. The aim of the study was to investigate the level of skeletal muscle damage markers in A (H1N1v) virus infection. Methods. 135 patients with pneumonia associated with influenza A (H1N1v) were examined in Chita in season 2009-2010. Of them 58 (group I) were hospitalized to the ICU. Group II included 77 patients in the pulmonological department. 20 patients died. The virus was verified by the PCR. Immunohistochemistry (IHC) study was performed using paraffin sections of kidney parenchyma by biotin-streptavidin immunoperoxidase method with anti-human myoglobin after the autopsy. Results. In Group I patients the increased CK levels were found in 68.9% of cases, LDH - in 79.3% of cases. In Group II CK and LDH levels were increased in 2.59% and 3.89% of patients, respectively. CK and LDH levels in the blood of patients died of influenza A (H1N1v) were 1088 U\L [780; 1550] and 895 [800; 1457], in survivors - 87 [62; 189] and 285 [235; 400 respectively. The presence of myoglobin in the lumen of kidney tubules by IHC was revealed in 18 fatal cases (90%). Conclusion. The increased level of CK and LDH in blood are the prognostic markers of the severity and mortality due to influenza A (H1N1v), associated with the presence of myoglobin in the kidney tubules.
Fertility in Single‐ovulating and Superovulated Dairy Heifers after Insemination with Low Dose Sex‐sorted Sperm (2010)

The present study was performed to test fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm under field conditions. Some parameters, including the dosage, deposition site and timing, were assessed with the pregnancy rates after artificial insemination (AI). Moreover, the use of oestrus synchronization in combination with sorted sperm was evaluated. Besides that, we also improved the embryo production efficiency in superovulated dairy heifers by optimizing the timing of inseminations and repartitioning the sexed sperm dosage among multiple inseminations. The conception rate (52.8%) in heifers after low dose (2 × 10(6) ) insemination with sorted sperm deep into the uterine horn did not differ (p > 0.05) from that (59.6%) of conventional AI (1 × 10(7) non-sorted sperm) and that of deep insemination with low dose non-sorted sperm (57.7%). There was also no difference (p > 0.05) between conception rates after single (51.7%) and double (53.8%) deep insemination with sorted semen. Heifers inseminated with sorted sperm at synchronous oestrus had a lower pregnancy rate (48.1%) than heifers at spontaneous oestrus (53.6%), but this did not reach statistical difference (p > 0.05). The average number of transferable embryos collected in vivo from heifers inseminated with sorted sperm (4.81 ± 2.04) did not differ (p > 0.05) from that obtained from heifers after insemination with non-sorted sperm (5.36 ± 2.74). Thus, we concluded that the pregnancy rate after deep intra-uterine insemination with low dose sorted sperm was similar to that of non-sorted sperm, which was either also deposited at a low dose deep intra-uterine or into the uterine body. Synchronization of oestrus can be beneficial in combination with sorted sperm to optimize the organization and management of dairy herds. The results from superovulated heifers demonstrated that our insemination regime can be used to obtain a comparable embryo production efficiency with sorted sperm than with non-sorted sperm.
Accelerating Reactive Compatibilization of PE/PLA Blends by an Interfacially Localized Catalyst (2014)

We show catalyst localized at the interface can compatibilize polyethylene (PE) and polylactide (PLA) blends. Telechelic hydroxyl functional PE was synthesized by ring opening metathesis polymerization, which reacted with PLA in melt mixing (shown by adhesion and droplet size reduction). Lewis acid tin catalysts were examined as interfacial reaction promoters, with the goal of interfacial localization. Stannous octoate was shown to localize at the interface by transmission electron microscopy with energy dispersive X-ray spectroscopy and improved dispersion of PLA in PE as compared to uncatalyzed materials and a nonlocalized tin chloride dihydrate.
The application of modern control theory to improve the quality of motion fidelity in ground based motion simulators (2003)

Optimization methods utilizing LQ (linear quadratic) techniques are applied to develop improved motion fidelity of a three-axis motion. The motion simulator (centrifuge) is modeled as a three-axis revolute robot. The optimization procedure is applied to minimize induced accelerations (Coriolis) that commonly occur. Computer simulations of these algorithms demonstrate that over 65% reduction of the untoward accelerations can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pattern reconfigurable antenna for Wireless LAN dual-band (2012)

A novel type of compact and printed pattern reconfigurable antenna for dual Wireless LAN application is presented. Dual band is realized by dipole and bow-tie antenna which is connected by a chip inductor. Also, each parasitic element as a reflector changes the direction of main beam. Results show good pattern reconfigurablity for WLAN dual band.
A Hall sensor microsystem with continuous gain calibration using fully integrated references (2012)

This paper presents an integrated Hall sensor microsystem with continuous gain calibration and a current-mode back-end. The integrated system includes a Hall sensor with internal biasing, a fully differential front-end, a preamplifier chain, a voltage-to-current converter and internal voltage and current references. The main feature of this microsystem is full integration, including the references, which guarantee the gain stability. The whole microsystem is integrated in a 0.35µm CMOS technology. It occupies an area of 11.55mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
633 nm Red Emissions from InGaN Nanocolumn Light-Emitting Diode by Radio Frequency Plasma Assisted Molecular Beam Epitaxy (2013)

GaN nanocolumns exhibiting high light-extraction property provide a platform for high-performance nano-devices. To improve the performance of nanocolumn LEDs, uniform arrays of InGaN-based multi quantum well (MQW) nanocolumns were fabricated. We report on red emitting nanocolumn LEDs with InGaN MQW grown on GaN templates by radio frequency plasma assisted molecular beam epitaxy (RF-MBE), for the first time. The electroluminescence peak wavelength and the full-width at half maximum at a drive current of 5 mA were 633 nm and 185 meV, respectively for the LEDs. It demonstrated a blue-shift of 5 nm for the 20 mA, indicating negligible polarization and band filling effects.
Patients Needing Cystoplasty (2006)

Expert’s summary: This paper reports the clinical results of augmentation cystoplasty undertaken with autologous tissueengineered bladder substitutes in seven patients with poorly compliant neurogenic bladders due to congenital myelomenigocele. Homologous bladder tissue was sampled from all patients by open biopsy 7–8 weeks before cystoplasty. Detrusor muscle cells were cultured and expanded in Dulbecco modified Eagle medium with 10% fetal bovine serum. Urothelial cells were expanded with keratinocyte growth medium. Cells required no more than five passages in each patient. The scaffolds used in the first four patients were made of homologous decellularised bladder submucosa; in the last three patients a biodegradable composite scaffold made of collagen and polyglycolic acid (PGA) was used. The total thickness of the scaffolds was 2.0 mm, and their size was fashioned according to volume calculations of the composite bladder according to the patient’s age and pelvic cavity dimensions. About 70 plates of each cell type (containing about 10 10 6 cells per
Some unique properties of in 2-fluorotoluene derivatives. Conformational dependence (1983)

A complete analysis of the 1 H nmr spectrum of 2-fluorotoluene yields [Formula: see text] the spin–spin coupling constant between 19 F and the methyl protons, as 1.99 Hz. Analysis of nmr spectra of 21 other derivatives of 2-fluorotoluene shows that [Formula: see text] can vary between 1.69 and 2.55 Hz. This strong dependence on substitution contrasts with the near invariance of other long-range couplings such as [Formula: see text], [Formula: see text], [Formula: see text] The substituent dependence is discussed in terms of coupling mechanisms. INDO MO FPT calculations of [Formula: see text] are inadequate. By means of appropriate model compounds, an adequate empirical conformational dependence is deduced for [Formula: see text] which can be used to reproduce some observed couplings. INDO MO FPT computations, in which certain off-diagonal Fock matrix elements are suppressed, are used to show that spin polarization via interacton of the methyl hydrogen orbitals is a major source of the discrepancy between theory and experiment. Some STO 3G MO calculations are reported for 2-fluorotoluene conformations.
First Total Synthesis of Bengazole A (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteADDITION / CORRECTIONThis article has been corrected. View the notice.First Total Synthesis of Bengazole A†Roger J. Mulder, Cynthia M. Shafer, and Tadeusz F. MolinskiView Author Information Department of Chemistry, University of California, 1 Shields Avenue, Davis, California 95616 Cite this: J. Org. Chem. 1999, 64, 13, 4995–4998Publication Date (Web):June 6, 1999Publication History Received14 April 1999Published online6 June 1999Published inissue 1 June 1999https://pubs.acs.org/doi/10.1021/jo9906328https://doi.org/10.1021/jo9906328brief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1204Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Aldehydes,Chemical synthesis,Mixtures,Pharmaceuticals Get e-Alerts
Non-perturbative uniform wavefunctions of coupled radial Schrodinger equations (1988)

A uniform approximation is used with the Green function method to find the total wavefunctions of scattering coupled equations. A simple and analytical expression of non-diagonal terms of the R matrix is derived.
Dynamic Nuclear Polarization in Silicon Microparticles (2008)

We report record high 29Si spin polarization obtained using dynamic nuclear polarization in microcrystalline silicon powder. Unpaired electrons in this silicon powder are due to dangling bonds in the amorphous region of this intrinsically heterogeneous sample. 29Si nuclei in the amorphous region become polarized by forced electron-nuclear spin flips driven by off-resonant microwave radiation while nuclei in the crystalline region are polarized by spin diffusion across crystalline boundaries. Hyperpolarized silicon microparticles have long T1 relaxation times and could be used as tracers for magnetic resonance imaging.
Probabilistic encryption & how to play mental poker keeping secret all partial information (2019)

research-article Share on Probabilistic encryption & how to play mental poker keeping secret all partial information Authors: Shafi Goldwasser University of California University of CaliforniaView Profile , Silvio Micali University of California University of CaliforniaView Profile Authors Info & Claims Providing Sound Foundations for Cryptography: On the Work of Shafi Goldwasser and Silvio MicaliOctober 2019 Pages 173–201https://doi.org/10.1145/3335741.3335749Published:04 October 2019Publication History 10citation140DownloadsMetricsTotal Citations10Total Downloads140Last 12 Months12Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Blocking and nonblocking multirate Clos switching networks (1998)

This paper investigates in detail the blocking and nonblocking behavior of multirate Clos switching networks at the connection/virtual connection level. The results are applicable to multirate circuit and fast-packet switching systems. Necessary and sufficient nonblocking conditions are derived analytically. Based on the results, an optimal bandwidth partitioning scheme is proposed to reduce switch complexity while maintaining the nonblocking property. The blocking behavior of blocking switches supporting multicast connections is investigated by means of simulation. We propose a novel simulation model that filters out external blocking events without distorting the bandwidth and fanout (for multicasting) distributions of connection requests. In this way, the internal blocking statistics that truly reflect the switch performance can be gathered and studied. Among many simulation results, we have shown that for point-to-multipoint connections, a heuristic routing policy that attempts to build a narrow multicast tree can have relatively low blocking probabilities compared with other routing policies. In addition, when small blocking probability can be tolerated, our results indicate that situations with many large-fanout connection requests do not necessarily require a switch architecture of higher complexity compared to that with only point-to-point requests.
The effects of intervention with local electrostatic air cleaners on airborne dust and the health of office employees (2005)

Electrostatic air cleaners can reduce the dust concentration effectively in the office environment. Small, medium and large sized particles can be reduced by approximately 50%, relatively most effectively for the respirable particles. However, the air cleaners tested in this study produced an annoying fan noise. Cleaning efficiency and noise data should be given consideration before installation. This experimental field study suggests that office workers with airways symptoms may benefit from installation of local electrostatic air cleaners.
Anti-Bacterial and Microecosystem-Regulating Effects of Dental Implant Coated with Dimethylaminododecyl Methacrylate (2017)

The effects of dimethylaminododecyl methacrylate (DMADDM) modified titanium implants on bacterial activity and microbial ecosystem of saliva-derived biofilm were investigated for the first time. Titanium discs were coated with DMADDM solutions at mass fractions of 0 mg/mL (control), 1, 5 and 10 mg/mL, respectively. Biomass accumulation and metabolic activity of biofilms were tested using crystal violet assay and MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. 16S rRNA gene sequencing was performed to measure the microbial community. Live/dead staining and scanning electron microscopy (SEM) were used to value the structure of biofilm. The results showed that the higher mass fraction of DMADDM the coating solution had, the significantly lower the values of metabolic activity and accumulated biofilms got, as well as fewer live cells and less extracellular matrix. Moreover, 5 mg/mL of DMADDM was the most effective concentration, as well as 10 mg/mL. In microecosystem-regulation, the DMADDM modified titanium implant decreased the relative abundance of <i>Neisseria</i> and <i>Actinomyces</i> and increased the relative abundance of <i>Lactobacillus</i>, a probiotic for peri-implant diseases. In conclusion, via inhibiting growth and regulating microecosystem of biofilm, this novel titanium implant coating with DMADDM was promising in preventing peri-implant disease in an 'ecological manner'.
Role of glucose in cloned mouse embryo development (2008)

Cloned mouse embryos display a marked preference for glucose-containing culture medium, with enhanced development to the blastocyst stage in glucose-containing medium attributable mainly to an early beneficial effect during the first cell cycle. This early beneficial effect of glucose is not displayed by parthenogenetic, fertilized, or tetraploid nuclear transfer control embryos, indicating that it is specific to diploid clones. Precocious localization of the glucose transporter SLC2A1 to the cell surface, as well as increased expression of glucose transporters and increased uptake of glucose at the one- and two-cell stages, is also seen in cloned embryos. To examine the role of glucose in early cloned embryo development, we examined glucose metabolism and associated metabolites, as well as mitochondrial ultrastructure, distribution, and number. Clones prepared with cumulus cell nuclei displayed significantly enhanced glucose metabolism at the two-cell stage relative to parthenogenetic controls. Despite the increase in metabolism, ATP content was reduced in clones relative to parthenotes and fertilized controls. Clones at both stages displayed elevated concentrations of glycogen compared with parthenogenetic controls. There was no difference in the number of mitochondria, but clone mitochondria displayed ultrastructural alterations. Interestingly, glucose availability positively affected mitochondrial structure and localization. We conclude that cloned embryos may be severely compromised in terms of ATP-dependent processes during the first two cell cycles and that glucose may exert its early beneficial effects via positive effects on the mitochondria.