gebhart/patrepeval huggingface dataset:
Life-Long Administration of Liposomes and Lipid A in Mice: Effects on Longevity, Antibodies to Liposomes, and Terminal Histopathological Patterns (1988)

Long-term effects of life-long (>2 year) repeated intravenous injections (up to 17) of high doses of liposomes, lipid A, or liposomes containing lipid A were assessed in BALB/c mice. the liposomes contained dipalmitoylphosphatidylcholine, and cholesterol (1/0.75). When compared with mice injected only with normal saline, there were no statistical differences in life spans observed between the different groups. Animals injected with liposomes or liposomes containing lipid A gradually developed “ruffled” fur, but the animals did not appear sick otherwise, and no differences were observed in the mean weights of the animals in the different groups. All of the animals that were tested in each group, including those injected with normal saline, developed IgG antibodies against one or more of nine lipid antigens. the antibodies were detected by a solid-phase enzyme-linked immunosorbent assay (ELisA) and the antigens consisted of either lipid A or one of eight different phospholipids. After 765 days, when approximately half of the animals had died spontaneously, the surviving animals were sacrificed and subjected to extensive histopathological analysis. In each group (including the normal saline group) certain animals exhibited pathological changes in liver, spleen, or lung that might be expected to occur in highly aged animals. Approximately half of the animals in each group had lymphoproliferative disorders (hyperplasia and/or lymphoma). However, there were no bone marrow abnormalities, and no hepatic or splenic granulomatous reactions were found in any of the animals. From a pathological standpoint the groups were indistinguishable from each other. We conclude that life-long repeated injection of liposomes, lipid A, or liposomes containing lipid A does not alter longevity or cause any overt pathological changes in mice. We also conclude that antibodies to lipid A and a variety of phospholipids occur spontaneously in aged mice that have been injected only with normal saline.
Locating Moving Objects over Mobile Sensor Network (2003)

Filarias is one major health problem in the coastal areas of Orissa including district Bhadrak. Tis article deals with 8 plant species used in native phytotherapy for filariasis in this region with the view to provide clue for further research.
Comparison of drying characteristics of Thompson seedless grapes using combined microwave oven and hot air drying (2011)

Comparison of drying characteristics of Thompson seedless grapes using combined microwave oven and hot air cabinet dryer was investigated. The drying rate curves indicated the absence of a constant-rate drying period in all drying methods. Within a certain microwave power range (75–900 W in the current study), increasing microwave power speeds up the drying process, thus shortening the drying time. No benefits were seen when increasing drying time from 30 to 120 min when grapes drying started in hot air cabinet dryer and finished in microwave oven for 1 min at any power level. The higher value of energy consumption during grapes drying belonged to hot air cabinet dryer alone as drying method with value of 564.5 MJ/kgwater evaporated. The average total soluble solids was 90.4° Brix when drying was achieved by microwave oven followed by hot air cabinet dryer, meanwhile, it was 90.2° Brix when drying was achieved by hot air cabinet dryer followed by microwave oven. The total soluble solid was 92° Brix when drying process started and finished in hot air cabinet dryer alone. The average drying ratio was 4.21 when drying was achieved by microwave oven followed by hot air cabinet dryer; meanwhile, it was 4.19 when drying was achieved by hot air cabinet dryer followed by microwave oven. The hot air cabinet drying method had higher drying constant ‘k’ compared to the other two methods. The microwave oven followed by hot air cabinet dryer as a drying method achieved 78% of the optimum selection percentage. However, the optimum drying method has a selection percentage of 100%.
OPTIMIZING PHARMACOKINETIC CHARACTERISTICS OF MONOCLONAL ANTIBODIES WITH CHEMICAL MODIFICATION (1997)

Sharifi, J.; Khawli, L. A.; Kang, H-Y.; Hornick, J. L.; Epstein, A. L.* Author Information
Gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma (2000)

BACKGROUND The authors conducted a Phase II study to evaluate the activity of the combination of gemcitabine and vinorelbine in patients with advanced nonsmall cell lung carcinoma (NSCLC). METHODS Patients were eligible if they had Stage IIIB (malignant pleural effusion) or Stage IV NSCLC, no prior chemotherapy, and Cancer and Leukemia Group B performance status (PS) 0–2. Patients with brain metastases were eligible if they were neurologically stable after brain irradiation. Thirty-three patients from participating institutions were enrolled. One patient was ineligible due to untreated brain metastases. Patients were treated with gemcitabine 1250 mg/m2 over 30 minutes (1000 mg/m2 for the first 6 patients) and vinorelbine 25 mg/m2 over 6 minutes, both administered intravenously on Days 1 and 8 every 21 days. Treatment was planned for a total of six cycles or more if the patient had persistent benefit. Growth factors were not allowed. RESULTS Among all 32 eligible patients, there were 8 partial responses, for an overall response rate of 25% (95% confidence interval [CI], 11.5–43.4%). The median survival time was 8.3 months and the 1-year survival rate was 38% (95% CI, 24–59%). Patients with PS 0–1 had a median survival of 11.7 months and a 1-year survival rate of 48%. Grade 3 and 4 neutropenia was observed in 13% and 25% of the 148 treatment cycles, respectively. One patient died of neutropenic sepsis. Only 2 episodes of Grade 3 and 4 thrombocytopenia were observed. Nonhematologic toxicity was minimal. CONCLUSIONS Gemcitabine and vinorelbine is an active and well-tolerated regimen in patients with advanced NSCLC, with response and survival rates at least comparable to those achieved with standard platinum-based regimens. This combination may be particularly suitable for the elderly or for patients who cannot tolerate more toxic platinum-based regimens. Cancer 2000;88:557–62. © 2000 American Cancer Society.
Multifractal analysis and authentication of Jackson Pollock paintings (2008)

Recent work has shown that the mathematics of fractal geometry can be used to provide a quantitative signature for the drip paintings of Jackson Pollock. In this paper we discuss the calculation of a related quantity, the "entropy dimension" and discuss the possibility of its use a measure or signature for Pollock's work. We furthermore raise the question of the robustness or stability of the fractal measurements with respect to variables like mode of capture, digital resolution, and digital representation and include the results of a small experiment in the step of color layer extraction.
Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination (2022)

Pyroptosis is a recently discovered form of inflammatory programmed necrosis characterized by caspase-1-mediated and gasdermin D-dependent cell death leading to the release of pro-inflammatory cytokines such as Interleukin-1 beta (IL-1β). Here, we evaluated whether pyroptosis could be exploited in DNA vaccination by incorporating a constitutively active variant of caspase-1 to the antigen-expressing DNA. In vitro, transfection with constitutively active caspase-1 DNA induced pro-IL-1β maturation and IL-1β release as well as gasdermin D-dependent cell death. To test active caspase-1 as a genetic adjuvant for the induction of antigen-specific T cell responses, mice were vaccinated intradermally with a DNA vaccine consisting of the active caspase-1 plasmid together with a plasmid encoding an ovalbumin-derived CD8 T cell epitope. Active caspase-1 accelerated and amplified antigen-specific CD8 T cell responses when administered simultaneously with the DNA vaccine at an equimolar dose. Moreover, upon challenge with melanoma cells expressing ovalbumin, mice vaccinated with the antigen vaccine adjuvanted with active caspase-1 showed significantly better survival compared to the non-adjuvanted group. In conclusion, we have developed a novel genetic adjuvant that for the first time employs the pyroptosis pathway to improve DNA vaccination against cancer.
Left ventricular strain and untwist in hypertrophic cardiomyopathy: Relation to exercise capacity (2010)

In nHCM patients, there are widespread abnormalities of both systolic and diastolic function. Reduced strain and delayed untwist contribute significantly to exercise limitation in nHCM patients.
6.5 kV schottky-barrier-diode-embedded SiC-MOSFET for compact full-unipolar module (2017)

For higher-voltage SiC modules, larger SBD chips are required as free-wheel diodes to suppress current conduction of the body diodes of MOSFETs, which causes bipolar degradation following the expansion of stacking faults. By embedding an SBD into each unit cell of a 6.5 kV SiC-MOSFET, we achieved, without using external SBDs, a high-voltage switching device that is free from bipolar degradation. Expansion of the active area by embedding SBDs is only 10% or less, whereas the active area of external SBDs can be over three times larger than that of the coupled MOSFET. The fabricated 6.5 kV SBD-embedded SiC-MOSFETs show sufficiently high breakdown voltages, low specific on-resistances, no bipolar degradation, and good reliability.
Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis (1998)

Objective To analyze the immunophenotype and functional properties of synovial mast cells (SyMC) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods Synovial tissue was obtained from 25 patients with RA and 17 patients with OA. Tissue was dispersed by enzymatic digestion using collagenase. Surface receptor expression on SyMC was analyzed by monoclonal antibodies (MAb) and indirect immunofluorescence staining. Histamine release experiments were performed using the MC agonist recombinant human (rHu) stem cell factor (SCF), the anaphylatoxin rHuC5a, and an anti-IgE antibody. Results In both groups of patients (RA and OA), SyMC were found to react with MAb to IgE, SCF receptor (c-kit, CD117), as well as CD antigens likewise expressed in lung MC (CD9, CD29, CD33, CD43, CD44, CD45). However, a significantly increased proportion of SyMC from RA patients reacted with MAb against C5a receptor (C5aR; CD88), compared with SyMC from OA (mean ± SD percentage of SyMC reacting with CD88 MAb S5/1 in RA 27.5 ± 8.6% versus 0.0% in OA, and with CD88 MAb W17/1 in RA 58.3 ± 15.2% versus 12.5 ± 15.0% in OA; P < 0.05). Furthermore, in RA, significant histamine release from SyMC above control was induced by rHuC5a, anti-IgE, and rHuSCF, whereas SyMC in OA released histamine after stimulation with anti-IgE and rHuSCF, but not rHuC5a. Conclusion SyMC exhibit phenotypic and functional properties similar to MC in other tissues. In patients with RA, but not OA, SyMC express significant amounts of C5aR (CD88) and release histamine in response to rHuC5a. These results indicate a role for SyMC and C5a/C5aR in the pathogenesis of RA.
Remote Side-Channel Attacks on Anonymous Transactions (2020)

Privacy-focused crypto-currencies, such as Zcash or Monero, aim to provide strong cryptographic guarantees for transaction confidentiality and unlinkability.In this paper, we describe side-channel attacks that let remote adversaries bypass these protections.We present a general class of timing side-channel and traffic-analysis attacks on receiver privacy.These attacks enable an active remote adversary to identify the (secret) payee of any transaction in Zcash or Monero.The attacks violate the privacy goals of these crypto-currencies by exploiting side-channel information leaked by the implementation of different system components.Specifically, we show that a remote party can link all transactions that send funds to a user, by measuring the response time of that user's P2P node to certain requests.The timing differences are large enough that the attacks can be mounted remotely over a WAN.We responsibly disclosed the issues to the affected projects, and they have patched the vulnerabilities.We further study the impact of timing side-channels on the zero-knowledge proof systems used in these cryptocurrencies.We observe that in Zcash's implementation, the time to generate a zero-knowledge proof depends on secret transaction data, and in particular on the amount of transacted funds.Hence, an adversary capable of measuring proof generation time could break transaction confidentiality, despite the proof system's zero-knowledge property.Our attacks highlight the dangers of side-channel leakage in anonymous crypto-currencies, and the need to systematically protect them against such attacks.
Increasing Binding Constants of Ligands to Carbonic Anhydrase by Using "Greasy Tails" (1995)

Two series of para-substituted benzenesulfonamides have been examined as inhibitors for bovine carbonic anhydrase II (CAII, EC 4.2.1.1). Both series have hydrophobic alkyl group R connected by amide linkages to the aromatic ring (H2NO2SC6H4-CH2NHCOR1 and H2NO2SC6H4-CONR2R3). The free energy of partitioning (delta Gp) of these ligands between water and octanol had similar, linear correlations with the molecular surface areas of the hydrophobic groups R; delta Gp was only relatively weakly influenced by the linkage to the benzenesulfonamide and the detailed structure of the group R. Binding of these ligands to CAII was more complicated. For compounds having the structure H2NO2SC6H4-L-R, the dependence of the free energy of binding to CAII on the surface area of the hydrocarbon (fluorocarbon) group R for different -L-R was (d delta Gb/dA, kcal/(mol.100 Angstrum 2): -CH2NHCORH, -0.71 +/- 0.03; -CH2NHCORF, -0.72 +/- 0.07; -CONHCH2RH, -2.5 +/- 0.1; and -CONHCH2RF, -2.7 +/- 0.3. The available data permit several conclusions: (i) details (linear, branched, cyclic) of the structure of the group RH are relatively unimportant in determining binding constants (although cyclic structures may bind slightly more strongly than acyclic ligands with the same carbon number); (ii) for a given class of compounds, binding constants of hydrocarbons and fluorocarbons having the same surface area are very similar; and (iii) the nature of the linker L influences the sensitivity of binding to the surface area of the group R, presumably by its influences in positioning the group in the binding pocket of the enzyme. Fluorocarbons seem to be more hydrophobic than hydrocarbons of the same carbon number because they have larger areas of hydrophobic surface; the hydrophobicity of hydrocarbon and fluorocarbon surfaces are similar, after correction for differences in area.
Respiratory and cardiac motion correction in dual gated PET/MR imaging (2015)

International audience
ARFTG Microwave Measurement Symposium 2022 [RWW 2022] (2021)

Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
Gene Delivery by Viruses (2005)

Abstract Viral vector systems are very useful for delivering genes to cells. Commonly used systems include vectors derived from retroviruses, lentiviruses, adenoviruses, adeno‐associated viruses and herpesviruses.
Quantification of the impaired cardiac output response to exercise in heart failure: application of a non-invasive device. (2009)

An impaired cardiac output (CO) response to exercise is a hallmark of chronic heart failure (CHF), and the degree to which CO is impaired is related to the severity of CHF and prognosis. However, practical methods for obtaining cardiac output during exercise are lacking, and what constitutes and impaired response is unclear. Forty six CHF patients and 13 normal subjects underwent cardiopulmonary exercise testing (CPX) while CO and other hemodynamic measurements at rest and during exercise were obtained using a novel, non-invasive, bioreactance device based on assessment of relative phase shifts of electric currents injected across the thorax, heart rate and ventricular ejection time. An abnormal cardiac output response to exercise was defined as achieving ≤ 95% of the confidence limits of the slope of the relationship between CO and oxygen uptake (VO2). An impaired CO slope identified patients with more severe CHF as evidenced by a lower peak VO2, lower peak CO, heightened VE/VCO2 slope, and lower oxygen uptake efficiency slope. CO can be estimated during exercise using a novel bioreactance technique; patients with an impaired response to exercise exhibit reduced exercise capacity and inefficient ventilation typical of more severe CHF. Non- invasive measurement of cardiac performance in response to exercise provides a simple method of identifying patients with more severe CHF and may complement the CPX in identifying CHF patients at high risk. Key pointsNon-invasive measurement of cardiac output during exercise is feasible in patients with heart failure.Impairment in the CO response to exercise identifies heart failure patients with more severe disease, lower exercise capacity and inefficient ventilation.Non-invasive measurement of cardiac performance during exercise has potentially important applications for the functional and prognostic assessment of patients with heart failure.
Effect of UV-wavelength on Hardening Process of Porogen-containing and Porogen-free Ultra-low-k PECVD Glasses (2010)

The ITRS scaling of ultra-large-scale integrated circuits requires mechanically robust materials with low k-value. Low-k materials recently used in the Cu/low-k integration scheme have k-values between 2.5 and 3.0. One of the limiting factors in further reduction of k-value is mechanical robustness, since major way to decrease k-value is increasing the material porosity. The PECVD low-k deposition of ultra low-k films uses a porogen-based approach. The matrix material is deposited by oxidation of alkylsilanes in a plasma-enhanced chemical vapor deposition (PECVD) process. The porogen molecules, usually cyclic hydrocarbons, are introduced into a SiOCH film by co-deposition with the matrix material. To create porosity, the porogen is removed from the films using UV-assisted-thermal curing. The porogen molecules are photo-dissociated by UV-light with the formation of volatile hydrocarbons and non-volatile carbon-rich residues (porogen residue) [1]. We showed recently that SiOCH glasses with improved mechanical properties and ultra-low-k value could be obtained by controlled decomposition of the porogen molecules prior to the UV-hardening step [2]. The controlled removal of porogen can be performed by H2-based afterglow plasma treatment of PECVD film [1,2]. In this work we study the effect of narrow band 172 nm and broadband >200 nm UV-sources in the new curing scheme of the PECVD dielectrics. The data are compared with the PECVD films fabricated in the conventional UV-curing scheme. The effect of both 172 nm and >200 nm UV-sources is comparable for porogen-containing conventional PECVD films. However, the porogen-free films cured with 172 nm UV-source shows approximately twice as higher Young’s modulus of 6.64 GPa (k100kHz ~ 2.2, 44% open porosity) than those cured with >200 nm UV with YM of 3.38 GPa (k100kHz ~ 2.0, 48% open porosity). The mechanical properties, optical properties 150 nm - 800 nm, dielectric constants at 100 kHz and 4 GHz, porosities and pore size distributions, bonding structure are presented. The impact of porogen on optical characteristic and therefore on photochemical UV-hardening mechanism is discussed. The achieved mechanical properties are explained on a basis of the percolation of rigidity theory and random network concepts. References [1] A. M. Urbanowicz, K. Vanstreels, D. Shamiryan, S. De Gendt and M. Baklanov, Electrochem. Solid State Lett., 12, H292 (2009). [2]Urbanowicz, K. Vanstreels, P. Verdonck, D. Shamiryan, S. De Gendt and M. R. Baklanov, 107 (7), J. Appl. Phys. (2010).
A Pitch-Matched Analog Front-End with Continuous Time-Gain Compensation for High-Density Ultrasound Transducer Arrays (2021)

This paper presents a compact analog front-end (AFE) circuit integrated with a 100µm-pitch 2D ultrasound transducer array for 3D imaging. To realize time-gain compensation, it consists of two variable gain stages, both of which employ a novel complementary current-steering network to realize continuously-variable gain. The first stage is a transimpedance amplifier with a hardware-sharing current-reuse input stage to save power and area. The second stage is a class-AB current amplifier. Per channel, the AFE occupies only 0.025 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consumes 0.8 mW and achieves an input noise density of 1.31 pA/ <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\sqrt{\mathbf{H}} \mathbf{z}$</tex> . The measured gain error of ±0.4 dB within a 36 dB overall gain range is 2.5 times better than the prior art.
On Parity-Preserving Constrained Coding (2019)

Necessary and sufficient conditions are presented for the existence of fixed-rate parity-preserving encoders for a given constraint. It is also shown that under somewhat stronger conditions, the stethering method guarantees an encoder that has finite anticipation.
Comparison between collision induced dissociation of electrosprayed protonated peptides in the up-front source region and in a low-energy collision cell (1999)

A systematic comparison between the up-front Collision induced dissociation (CID) mass spectra and low-energy CID tandem mass spectra from twenty-one singly and/or doubly charged peptides has been made. CID spectra of the peptides were recorded at different electrode voltages in the up-front source region of a single quadrupole instrument and different collision energies in the collision cell of a tandem quadrupole instrument. It was observed that up-front CID and low-energy CID yielded comparable product ion spectra from protonated peptides, and that the instrumental settings necessary for obtaining comparable CID mass spectra from the two methods are correlated.