gebhart/patrepeval huggingface dataset:
Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages (2009)

Vasoactive intestinal peptide (VIP) was originally isolated as a vasodilator intestinal peptide, then as a neuropeptide.In the immune system, VIP is described as an endogenous macrophage-deactivating factor.VIP exerts its immunological actions in a paracrine and/or autocrine manner, through specific receptors.However, very little is known about the molecular regulation of VIP type 2 receptor (VPAC2) in the immune system.We now report that different toll-like receptor (TLR) ligands selectively regulate the VPAC2 receptor gene and show a gene repression system controlled by key protein kinase signalling cascades in macrophages.VPAC2 gene expression is regulated by gram-positive (TLR2 ligands) and gram-negative bacteria wall constituents (TLR4 ligands).Moreover, VPAC2 is tightly regulated: TLR2-or TLR2/6-but not TLR2/1-mediated mechanisms are responsible for the induction of VPAC2 .TLR stimulation by viral or bacterial nucleic acids did not modify the VPAC2 mRNA levels.Remarkably, imiquimod -a synthetic TLR7 ligand -led to a potent up-regulation of VPAC2 gene expression.TLR5 stimulation by flagellin present in gram-positive and gram-negative bacteria did not affect VPAC2 mRNA.The p38 mitogen-activated protein kinase (MAPK) activity accounted for the TLR4-mediated induction of VPAC2 gene expression.Surprisingly, our data strongly suggest for the first time a tightly repressed control of VPAC2 mRNA induction by elements downstream of MAPK kinase 1/2, PI3K/Akt, and particularly Jun-NH2 -terminal kinase signalling pathways.
Advanced 3D signal processing for Virtual Team User Environments (2003)

In this paper we present an advanced 3D signal processing for an extended architecture of 'Virtual Team User Environments (VIRTUE)' - a proposed concept on immersive 3D videoconferencing. Due to certain reasons the current VIRTUE architecture is restricted to a connection between three single user terminals. To overcome these shortcomings, a flexible multi-user concept is currently under investigation. One key challenge of such a multi-user concept is a robust 3D video processing including tracking, segmentation and depth analysis, which can be applied to a couple of participants sitting in front of the extended VIRTUE terminal. Against this background this paper presents a joint segmentation and disparity estimation approach which allows an accurate and robust 3D analysis providing the required input for an arbitrary synthesis of virtual views at the remote stations.
Supplemental Figure 7 from Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900 (2023)

&lt;p&gt;GNE-900 is more potent at chemopotentiation in p53 null HCT-116.&lt;/p&gt;
Computing H-infinity Norms of Time-Delay Systems (2020)

In this paper we consider the computation of H-infinity norm of retarded time-delay systems with discrete pointwise state delays. It is well known that in the finite dimensional case H-infinity norm of a system is computed using the connection between the singular values of the transfer function and the imaginary axis eigenvalues of an Hamiltonian matrix. We show a similar connection between the singular values of a transfer function of a time-delay system and the imaginary axis eigenvalues of an infinite dimensional operator $\mathcal{L}_ξ$. Using spectral methods, this linear operator is approximated with a matrix. The approximate H-infinity norm of the time-delay system is calculated using the connection between the imaginary eigenvalues of this matrix and the singular values of a finite dimensional approximation of the time-delay system. Finally the approximate results are corrected by solving a set of equations which are obtained from the reformulation of the eigenvalue problem for $\mathcal{L}_ξ$ as a finite dimensional nonlinear eigenvalue problem.
Nonlinear impact of diverse optical routing in uncompensated 120 Gb/s PM-QPSK links (2014)

We experimentally examine nonlinear penalties for 120 Gb/s PM-QPSK signals in uncompensated links with co-propagating channels added and dropped along the link. Dependencies on add/drop frequency and pre-dispersion on the add channels are also investigated.
Microemulsions formed from nonionic surfactants in near-critical and supercritical alkanes: quasi-elastic light scattering investigations (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicroemulsions formed from nonionic surfactants in near-critical and supercritical alkanes: quasi-elastic light scattering investigationsEric J. Beckman and Richard D. SmithCite this: J. Phys. Chem. 1990, 94, 9, 3729–3734Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/j100372a069https://doi.org/10.1021/j100372a069research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cemented injectable multi-phased porous bone grafts for the treatment of femoral head necrosis (2019)

Cemented injectable multi-phased porous bone grafts for the treatment of femoral head necrosis.
Phylogenetic Analysis of Heat Shock Proteins in Glassy-Winged Sharpshooter,Homalodisca vitripennis (2009)

The glassy-winged sharpshooter, Homalodisca vitripennis (Germar) (Hemiptera: Cicadellidae), is the major vector of Xylella fastidiosa Wells et al., the causal agent of Pierce's disease of grapes, Vitis spp. More research on leafhopper stress response is possible as more genomic information becomes available. To gain information on the stress response of the glassy-winged sharpshooter, a cDNA library was constructed from adults and fifth instars, resulting in 5,906 expressed sequence tags (ESTs). After quality scoring, 4,445 sequences underwent assembly, which produced a set of 2,123 sequences that putatively represented distinct transcripts. BLASTX analysis identified four significant homology matches to heat shock proteins (HSP), which are the focus of this study. The overall importance and function of heat shock proteins lie in their ability to maintain protein integrity and activity during stressful conditions, such as extreme heat, cold, or drought. Phylogenetic analyses using these four heat shock protein sequences provided further support of transcript by the identification of specific motifs. This study shows that highly conserved genes such as heat shock proteins are a viable supplement to ribosomal DNA in elucidating phylogenetic relationships.
An image signature for any kind of image (2003)

We describe an algorithm for computing an image signature, suitable for first-stage screening for duplicate images. Our signature relies on the relative brightness of image regions, and is generally applicable to photographs, text documents, and line art. We give experimental results on the sensitivity and robustness of signatures for actual image collections, and also results on the robustness of signatures under transformations such as resizing, rescanning, and compression.
Bug resolution catalysts: Identifying essential non-committers from bug repositories (2013)

Bugs are inevitable in software projects. Resolving bugs is the primary activity in software maintenance. Developers, who fix bugs through code changes, are naturally important participants in bug resolution. However, there are other participants in these projects who do not perform any code commits. They can be reporters reporting bugs; people having a deep technical know-how of the software and providing valuable insights on how to solve the bug; bug-tossers who re-assign the bugs to the right set of developers. Even though all of them act on the bugs by tossing and commenting, not all of them may be crucial for bug resolution. In this paper, we formally define essential non-committers and try to identify these bug resolution catalysts. We empirically study 98304 bug reports across 11 open source and 5 commercial software projects for validating the existence of such catalysts. We propose a network analysis based approach to construct a Minimal Essential Graph that identifies such people in a project. Finally, we suggest ways of leveraging this information for bug triaging and bug report summarization.
Collusion-secure fingerprinting and B/sub 2/-sequences (2002)

We discuss a strategy initiated by Boneh and Shaw (see IEEE Trans. Inform. Theory, vol.44, p.1897-1905, 1998) for collusion-secure fingerprinting. We show that under this strategy, finding fingerprinting schemes that resist coalitions of two users amounts to finding B/sub 2/-sequences of binary vectors. A sequence of vectors v/sub 1/, v/sub 2/,..., v/sub n/ is a B/sub 2/-sequence if all sums v/sub i/+v/sub j/, 1/spl les/i/spl les/j/spl les/n, are different: the associated extremal set-theoretic problem is what is the maximal size of a B/sub 2/-sequence? We shed new light on this old combinatorial problem and improve on previously known upper bounds.
Timing Advance Estimation and Beamforming of Random Access Response in\n Crowded TDD Massive MIMO Systems (2018)

Timing advance (TA) estimation at the base station (BS) and reliable decoding\nof random access response (RAR) at the users are the most important steps in\nthe initial random access (RA) procedure. However, due to the limited\navailability of physical resources dedicated for RA, successful completion of\nRA requests would become increasingly difficult in high user density scenarios,\ndue to contention among users requesting RA. In this paper, we propose to use\nthe large antenna array at the massive MIMO BS to jointly group RA requests\nfrom different users using the same RA preamble. We then beamform the common\nRAR of each detected user group onto the same frequency resource, in such a way\nthat most users in the group can reliably decode the RAR. The proposed RAR\nbeamforming therefore automatically resolves the problem of collision between\nmultiple RA requests on the same RA preamble, which reduces the RA latency\nsignificantly as compared to LTE. Analysis and simulations also reveal that for\na fixed desired SINR of the received RAR, both the required per-user RA\npreamble transmission power and the total RAR beamforming power can be\ndecreased roughly by 1.5 dB with every doubling in the number of BS antennas.\n
Subthreshold Operation of CAAC-IGZO FPGA by Overdriving of Programmable Routing Switch and Programmable Power Switch (2016)

A field-programmable gate array (FPGA) using a crystalline oxide semiconductor of c-axis-aligned crystal indium-gallium-zinc oxide (CAAC-IGZO) has been developed, which is capable of subthreshold operation used for energy harvesting. To achieve subthreshold operation, the CAAC-IGZO FPGA has a structure designed as an extension of a boosting pass gate using a CAAC-IGZO FET and employs overdriving of a programmable routing switch and a programmable power switch for power gating (PG). A CAAC-IGZO FET is used to give an ideal floating gate with excellent charge retention. A chip fabricated using a 0.8-μm CAAC-IGZO/0.18-μm CMOS hybrid process achieves subthreshold operation while maintaining the features required for normally off computing proposed in our previous study. Specifically, these features are realized by fine-grained PG for individual programmable logic elements (PLEs), fast configuration switching between contexts, and load/store between a volatile register and a nonvolatile shadow register in the PLEs. The chip operation at a minimum operating voltage of 180 mV with a combinational circuit configuration is demonstrated. With a sequential circuit configuration, the chip operates at a minimum operating voltage of 190 mV with 12.5 kHz, and the minimum power-delay product is 3.40 pJ/operation at 330 mV.
Heteroepitaxy of Group IV-VI Nitrides by Atomic Layer Deposition (2013)

Heteroepitaxial growth of selected group IV-VI nitrides on various orientations of sapphire (α-Al2O3) is demonstrated using atomic layer deposition. High quality, epitaxial films are produced at significantly lower temperatures than required by conventional deposition methods. Characterization of electrical and superconducting properties of epitaxial films reveals a reduced room temperature resistivity and increased residual resistance ratio (RRR) for films deposited on sapphire compared to polycrystalline samples deposited concurrently on fused quartz substrates.
Some Observations on the Palladium-Catalyzed Triflate-Arene Cyclization of Electron-Rich Biaryl Substrates (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Observations on the Palladium-Catalyzed Triflate-Arene Cyclization of Electron-Rich Biaryl SubstratesJoseph E. Rice, Zhen-Wei Cai, Zhen-Min He, and Edmond J. LaVoieCite this: J. Org. Chem. 1995, 60, 24, 8101–8104Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/jo00129a064https://doi.org/10.1021/jo00129a064research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Capacity maximising efficient adaptive subcarrier selection in OFDM with limited feedback (2006)

Proposed is an efficient adaptive subcarrier selection algorithm to maximise the capacity of orthogonal frequency division multiplexing (OFDM) transmission with limited feedback. The proposed adaptive subcarrier selection algorithm makes it feasible to select subcarriers to maximise the capacity with limited feedback and low complexity, and furthermore provides higher capacity than that obtained by the water-filling approach by reflecting the effect of rate quantisation.
Observed Hysteresis of Virus Capsid Disassembly Is Implicit in Kinetic Models of Assembly (2003)

For many protein multimers, association and dissociation reactions fail to reach the same end point; there is hysteresis preventing one and/or the other reaction from equilibrating. We have studied in vitro assembly of dimeric hepatitis B virus (HBV) capsid protein and dissociation of the resulting T = 4 icosahedral capsids. Empty HBV capsids composed of 120 capsid protein dimers were more resistant to dissociation by dilution or denaturants than anticipated from assembly experiments. Using intrinsic fluorescence, circular dichroism, and size exclusion chromatography, we showed that denaturants dissociate the HBV capsids without unfolding the capsid protein; unfolding of dimer only occurred at higher denaturant concentrations. The apparent energy of interaction between dimers measured in dissociation experiments was much stronger than when measured in assembly studies. Unlike assembly, capsid dissociation did not have the concentration dependence expected for a 120-subunit complex; consequently the apparent association energy systematically varied with reactant concentration. These data are evidence of hysteresis for HBV capsid dissociation. Simulations of capsid assembly and dissociation reactions recapitulate and provide an explanation for the observed behavior; these results are also applicable to oligomeric and multidomain proteins. In our calculations, we find that dissociation is impeded by temporally elevated concentrations of intermediates; this has the paradoxical effect of favoring re-assembly of those intermediates despite the global trend toward dissociation. Hysteresis masks all but the most dramatic decreases in contact energy. In contrast, assembly reactions rapidly approach equilibrium. These results provide the first rigorous explanation of how virus capsids can remain intact under extreme conditions but are still capable of "breathing." A biological implication of enhanced stability is that a triggering event may be required to initiate virus uncoating.
Adenovirus canin type 2 et transfert de gene (1997)

Un vecteur defectif pour la replication, exprimant le gene de la -galactosidase, a ete derive de l'adenovirus canin type 2 (cav2). Ce virus recombinant possede la capacite de transduire des cellules de mammiferes de diverses origines et en particulier des cellules primaires humaines. Malgre un systeme de production qu'il reste a optimiser, des experiences de transfert de gene in vivo dans l'embryon de poulet et dans le systeme nerveux central de rat ont ete conduites. Lors de l'infection de cellules humaines kb par l'adenovirus canin type 2, le cycle productif viral est bloque. Une reponse cellulaire de type apoptotique apparait 24 heures apres l'initiation de la replication virale. Un des transcrits majoritaires e1b n'est pas exprime apres infection de cellules kb par cav2. Ce defaut dans l'expression de e1b serait implique dans l'absence de controle, par le virus, de l'apoptose induite en reponse a l'infection par cav2. L'apoptose est proposee comme un des mecanismes regissant le maintien de la barriere d'espece au cours d'une infection par l'adenovirus.
High Power and Stable High Coupling Efficiency (66%) Superluminescent Light Emitting Diodes by Using Active Multi-Mode Interferometer (2011)

The fabricated 1.55µm high power superluminescent light emitting diodes (SLEDs) with 115mW maximum output power and 3dB bandwidth of 50nm, using active multi-mode interferometer (MMI), showed high coupling efficiency of 66% into single-mode fiber, which resulted in maximum fiber-coupled power of 77mW.
Allogeneic Stem Cell Transplantation for Relapsed Hodgkin’s Disease - a Single Centre Experience (2008)

Abstract Hodgkin’s disease can be cured by chemotherapy in the majority of cases. However a small proportion of patients show an aggressive course with multiple relapses after chemotherapy including autologous stem cell transplantation. Whether allogeneic stem cell transplantation constitutes a valid therapeutic option for these patients remains highly controversial. We report on our experience on 9 patients with Hodgkin’s disease receiving an allogeneic stem cell transplant from matched related (n=3), matched unrelated (n=1) or mismatched unrelated (2× 9/10, 2 ×8/10, 1× 7/10) donors. Median age was 28 years (range 18 – 35). All patients were extensively pre-treated including high-dose chemotherapy with autologous stem cell transplantation in 8 of 9 cases. The disease status before transplantation was CR (n=1), PR (n=5), SD (n=2) or progressive disease in 1 case. Conditioning treatment consisted of fludarabine 30 mg/m2 day -8 to -4, melphalan 70 mg/m2 day -3 to -2 and ATG 10–20 mg/kg day -4 to -2. Ciclosporin A and short course methotrexate was used for prophylactic immunosuppression. All patients showed prompt engraftment. Acute GvHD was found in 2 patients (Grade IV n=1, Grade I n=1), chronic GvHD did not occur after a median follow up of 471 days for the surviving patients. Two patients died from treatment-related causes, one from GvHD and one from septicemia. Estimated 2 year survival is 78%. Three patients have relapsed so far at day 128, 192 and 201 post transplant and received donor lymphocyte infusions or chemotherapy. The estimated 2 year disease free survival is 57%. Our results show a good feasibility of an allogeneic stem cell transplantation with reduced intensity conditioning for relapsed Hodgkin’s disease despite extensive pre-treatment and mostly partial remissions at transplant. The rate of acute and chronic GvHD was remarkably low in view of the fact, that 5 of 9 patients had mismatched unrelated donors. In summary allogeneic stem cell transplantation should be further exploited as treatment option for refractory and relapsed Hodgkin’s disease in younger patients.
Sub-500 ps 64 b ALUs in 0.18 μm SOI/bulk CMOS: Design & scaling trends (2002)

The requirements of high-throughput Internet servers necessitate the use of multiple ALUs in high-performance 64 b execution cores. Consequently, each ALU demands a compact, energy-efficient 64 b adder core with single-cycle latency. The resultant critical path, which is a balanced mix of interconnect, diffusion and gate loads, forms a representative test bed for evaluating competing circuit techniques and process technologies (bulk CMOS/SOI). This paper presents: (i) the design of an energy-efficient 64 b ALU in 0.18 /spl mu/m bulk CMOS technology; (ii) a direct port of this design to a comparable SOI technology and (iii) an SOI-optimal redesign of the adder core. Further, it describes design margining required for the SOI implementations and reports the results of shrinking the two architectures to 0.13 /spl mu/m Bulk/SOI. In both cases, a sophisticated SOI compact model that incorporates features to effectively model the SOI floating body effect is used.
Privacy-aware personalization for mobile advertising (2012)

Mobile advertising is an increasingly important driver in the Internet economy. We point out fundamental trade-offs between important variables in the mobile advertisement ecosystem. In order to increase relevance, ad campaigns tend to become more targeted and personalized by using context information extracted from user's interactions and smartphone's sensors. This raises privacy concerns that are hard to overcome due to the limited resources (energy and bandwidth) available on the phones. We point out that in the absence of a trusted third party, it is impossible to maximize these three variables - ad relevance, privacy, and efficiency - in a single system. This leads to the natural question: can we formalize a common framework for personalized ad delivery that can be instantiated to any desired trade-off point? We propose such a flexible ad-delivery framework where personalization is done jointly by the server and the phone. We show that the underlying optimization problem is NP-hard and present an efficient algorithm with a tight approximation guarantee.