gebhart/patrepeval huggingface dataset:
Preparation of Optically Transparent Open‐Celled Foams and its Morphological Characterization Employing Volume Image Analysis (2011)

Abstract Transparent glass sponges are a new class of materials that can potentially be used for effective light dispersion in photobioreactors. In this work, transparent glass sponges are prepared by the polymer replica technique employing polyurethane sponges with cell sizes of 20 pores per inch as templates and commercially available nanoscaled SiO 2 powders. Necessary conditions for obtaining transparent open‐celled glass sponges are presented. Topics such as slurry stabilization, temperature for burning‐out the polymer and subsequent sintering of the remaining SiO 2 structure to transparent cellular bodies are discussed. It was found, that concentrated suspensions at around pH 10 offer suitable properties for both, bringing enough particles onto the polymer template for the formation of a stable and self‐supporting SiO 2 shell and for successful sintering of the particulate framework to transparent bodies. Therefore, an adjusted burning‐out process and an adequate sintering regime is presented. Furthermore, the resulting sponge structure is characterized employing X‐Ray diffractometry, light, and scanning electron microscopy. In addition, volume image analysis was performed using magnetic resonance imaging. This method allows the calculation of geometrical parameters like cell‐size and specific surface area of the resulting structure, required for application of the new material.
Parkinson disease ( PARK ) genes are somatically mutated in cutaneous melanoma (2016)

The overrepresentation of somatic PARK mutations in CM suggests shared dysregulated pathways for CM and PD.
Data from Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Human cell lines are useful for studying cancer biology and preclinically modeling cancer therapy, but can be misidentified and cross-contamination is unfortunately common. The purpose of this study was to develop a panel of validated head and neck cell lines representing the spectrum of tissue sites and histologies that could be used for studying the molecular, genetic, and phenotypic diversity of head and neck cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; A panel of 122 clinically and phenotypically diverse head and neck cell lines from head and neck squamous cell carcinoma, thyroid cancer, cutaneous squamous cell carcinoma, adenoid cystic carcinoma, oral leukoplakia, immortalized primary keratinocytes, and normal epithelium was assembled from the collections of several individuals and institutions. Authenticity was verified by carrying out short tandem repeat analysis. Human papillomavirus (HPV) status and cell morphology were also determined.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Eighty-five of the 122 cell lines had unique genetic profiles. HPV-16 DNA was detected in 2 cell lines. These 85 cell lines included cell lines from the major head and neck primary tumor sites, and close examination shows a wide range of &lt;i&gt;in vitro&lt;/i&gt; phenotypes.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This panel of 85 genomically validated head and neck cell lines represents a valuable resource for the head and neck cancer research community that can help advance understanding of the disease by providing a standard reference for cell lines that can be used for biological as well as preclinical studies. &lt;i&gt;Clin Cancer Res; 17(23); 7248–64. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: Spirocyclic Nonpeptide Glycoprotein IIb—IIIa Antagonists. Part 3. Synthesis and SAR of Potent and Specific 2,8‐Diazaspiro[4.5]decanes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modelling of system components for Vehicle-to-Grid (V2G) and Vehicle-to-Home (V2H) applications with Plug-in Hybrid Electric Vehicles (PHEVs) (2012)

In the coming years, Plug-in Hybrid Electric Vehicles (PHEVs) will strongly penetrate in the car fleet. Currently, this theme represents an important area of research. In this paper, we proposed and make available all tools to conduct research on the impact of PHEVs on electric grids or to realize the energy management for Vehicle-to-Grid (V2G) and Vehicle-to-Home (V2H) applications with PHEVs.
Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network (2012)

A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.
Analysis of Progressive Neovascularization in Diabetic Retinopathy Using Widefield OCT Angiography (2021)

We quantified the size and density of NVE lesions over time. The NVE size increase was associated significantly with the severity of ischemic changes. Furthermore, the round growth pattern was correlated significantly with the ischemic index. These findings suggest that the morphologic features of NVE are associated with more severe ischemia.
P13.07 Cysteine induces glioblastoma cytotoxicity through mitochondrial reductive stress (2021)

Abstract BACKGROUND Glioblastoma (GBM) remains a poorly treatable disease with high mortality. Tumor metabolism in GBM is a critical mechanism responsible for accelerated growth because of upregulation of glucose, amino acid, and fatty acid utilization. However, therapies targeting GBM metabolism, whether through the use of small-molecule compounds or dietary interventions to limit nutrient sources, have failed in clinical trials. Metabolic bypass is an important mechanism that is often overlooked in GBM trials, since many trials have focused instead on combining anti-metabolic therapy with cytotoxic treatments. The goal of this research is to use a multi-pronged treatment approach with targeted drug and dietary therapy to leverage metabolic susceptibilities in GBM. MATERIALS AND METHODS We first interrogated the TCGA database and a cancer metabolite database for alterations in glucose and amino acid signatures in GBM relative to other human cancers and relative to low-grade glioma. We identified the amino acid cysteine as contributing to a novel metabolic susceptibility pathway in GBM. To study the role of cysteine in GBM pathogenesis, we treated patient-derived GBM cells with a variety of FDA-approved cysteine-promoting compounds in vitro, including N-acetylcysteine (NAC). We measured cell proliferation, energy production, mitochondrial metabolism, and reactive oxygen species to study mechanisms of oxidoreductive stress. Results: From our TCGA and cancer metabolite database analyses, we found that GBM exhibits the highest levels of cysteine and methionine pathway gene expression of 32 human cancers and that GBM exhibits high levels of cysteine-related metabolites compared to low-grade gliomas. Cysteine compounds, including NAC, reduce growth of GBM cells, which is exacerbated by glucose deprivation. This growth inhibition is associated with reduced mitochondrial metabolism, manifest by reduction in ATP generation, NADPH/NADP+ ratio, mitochondrial membrane potential, and oxygen consumption rate. Through measurement of mitochondrial hydrogen peroxide, we found that NAC-treated cells exhibit a paradoxical increase in mitochondrial hydrogen peroxide levels, likely due to inhibition of thioreductase and glutathione reductase systems. Through genetic and pharmacological studies, we found that induction of thioredoxin-2 rescues NAC-mediated cytotoxicity and that inhibition of thioreductase and glutathione reductase exacerbates mitochondrial toxicity and reductive stress. CONCLUSIONS We show that cysteine compounds reduce cell growth and induce mitochondrial toxicity in GBM through reductive stress. This metabolic phenotype is exacerbated by glucose deprivation. This pathway is targetable with FDA-approved cysteine-promoting compounds and could synergize with glucose-lowering treatments, including the ketogenic diet, for GBM.
GeNets: a unified web platform for network-based genomic analyses (2018)

Functional genomics networks are widely used to identify unexpected pathway relationships in large genomic datasets. However, it is challenging to compare the signal-to-noise ratios of different networks and to identify the optimal network with which to interpret a particular genetic dataset. We present GeNets, a platform in which users can train a machine-learning model (Quack) to carry out these comparisons and execute, store, and share analyses of genetic and RNA-sequencing datasets.
Performance of Autonomous Uplink Transmissions in Unlicensed Spectrum LTE (2017)

The immediate availability of Uplink (UL) time-frequency resources for transmission of new data is a key factor in reducing latency and improving UL throughput in cellular systems. This is particularly important for unlicensed spectrum operation where access to the channel is subject to Listen-Before-Talk (LBT), and scheduling UL transmissions with a preceding Downlink (DL) transmission as in Long-Term Evolution (LTE) can be inefficient. Therefore, this work proposes and studies autonomous UL transmissions (AUL) for LTE-based systems in unlicensed spectrum, where UL transmissions are allowed without requiring a prior scheduling request or an explicit scheduling grant from the Evolved Node B (eNB). The implications of AUL transmissions for the design of hybrid automatic repeat request (HARQ) and link adaptation mechanisms are investigated. Detailed performance evaluations in the 5 GHz unlicensed band show that dynamic switching between scheduled and autonomous UL transmissions offers the best throughput performance, while also coexisting fairly with co-channel Wi-Fi networks.
Risk Factors for Bronchiectasis in Children with Cystic Fibrosis (2013)

Neutrophil elastase activity in BAL fluid in early life was associated with early bronchiectasis in children with cystic fibrosis. (Funded by the National Health and Medical Research Council of Australia and Cystic Fibrosis Foundation Therapeutics.)
ChemInform Abstract: Antisense Oligonucleotides with Alternating Phosphodiester‐“Amide‐3” Linkages. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The TLR family protein RP105/MD-1 complex (2013)

The radioprotective 105 (RP105)/MD-1 complex is a member of the Toll-like receptor (TLR) family of proteins. We have previously reported that this complex cooperates with the essential lipopolysaccharide (LPS) receptor TLR4/MD-2 complex and plays a crucial role in LPS responses by B cells. Recent evidences suggest that TLRs can also recognize endogenous ligands and promote non-infectious chronic inflammation. For instance, TLR4/MD-2 can be ligated by adipose tissue-derived saturated free fatty acids (FAs) and induce adipose tissue inflammation and insulin resistance. Recently, we reported that RP105 knockout (KO) or MD-1 KO mice have less high-fat diet (HFD)-induced obesity, adipose tissue inflammation and insulin resistance than wild-type (WT) or TLR4 KO mice. As RP105/MD-1 is not involved in recognition of palmitic and stearic acids, which are endogenous ligands for TLR4/MD-2, we conclude that RP105/MD-1 is itself a key regulator of diet-induced chronic inflammation in adipose tissue, obesity and insulin resistance that appears to be independent of the TLR4-dependent pathway. In this mini-review, we will highlight the significance of the RP105/MD-1 complex in adipose tissue inflammation and discuss implications for human diseases.
Relationship between antithrombotic activities of fucans and their structure (2000)

Abstract A low molecular weight fucan fraction extracted from the brown seaweed Ascophyllum nodosum was previously shown to exhibit dose‐related venous antithrombotic activity with an ED 80 of about 20 mg/kg, 2 h after a single subcutaneous injection HCII (Colliec et al. [1991] Thromb Res 64:143–154; Mauray et al. [1995] Thromb Haemast 74:1280–1285). Its activity was comparable to that of a low molecular weight heparin (Dalteparin ® ). This fucan fraction is one of several, with a range of different structure parameters, prepared by degradation of the whole native fucan. These low molecular weight fractions were compared using a Wessler stasis thrombosis model in rabbits and by determination of their in vitro and ex vivo anticoagulant activities. Intravenous administrations of these fractions reduced thrombosis in a dose‐dependent manner. Partial removal of sulfate groups and/or partial degradation lead to a significant decrease in their anticoagulant and antithrombotic activities. The integrity of the regular pattern of sulphation of the fucoidan is necessary for antithrombotic activity. Drug Dev. Res. 51:216–224, 2000. © 2001 Wiley‐Liss, Inc.
A dye-sensitized solar cell based on a boron-doped ZnO (BZO) film with double light-scattering-layers structured photoanode (2014)

A double light-scattering-layer boron-doped ZnO (DL-BZO) film based dye-sensitized solar cell (DSSC) is fabricated with a high energy conversion efficiency of 7.2%. The over layer is made of well dispersed sub-micrometer-sized boron-doped ZnO (BZO) sphere arrays (SSA-BZO) to facilitate the fastest movement of electrons towards the electrodes and also function as light scattering centers. The under-layer, consisting of a nanoporous BZO nanoparticulate (NP-BZO) film, increases the dye adsorption and also reduces the injected electrons recombination. The DL-BZO film boosted the cell efficiencies because of its improved light-harvesting ability, larger surface area, photon-to-electron mechanism and doping of the ZnO films. The efficiency of 7.2% achieved for DL-BZO is much larger than the 4.1% obtained for double light-scattering-layers for undoped ZnO (DL-ZnO) films and is also higher than the 2.1% achieved for mono-layer NP-BZO films. Addition of an SSA-BZO layer over the NP-BZO layer significantly improves the transport of electrons and their lifetime when compared to the NP-BZO film only. The DL-BZO film exhibit the slowest recombination rate of changes compared with the other films and is found to be a major factor for the improved cell efficiency. The cells exhibit high stability, in terms of cell performance, even after 35 days. The highest efficiency achieved in the present study is the highest ever reported for a double light-scattering-layer ZnO film-based DSSC.
All-optical control and metrology of electron pulses (2016)

Short electron pulses are central to time-resolved atomic-scale diffraction and electron microscopy, streak cameras, and free-electron lasers. We demonstrate phase-space control and characterization of 5-picometer electron pulses using few-cycle terahertz radiation, extending concepts of microwave electron pulse compression and streaking to terahertz frequencies. Optical-field control of electron pulses provides synchronism to laser pulses and offers a temporal resolution that is ultimately limited by the rise-time of the optical fields applied. We used few-cycle waveforms carried at 0.3 terahertz to compress electron pulses by a factor of 12 with a timing stability of <4 femtoseconds (root mean square) and measure them by means of field-induced beam deflection (streaking). Scaling the concept toward multiterahertz control fields holds promise for approaching the electronic time scale in time-resolved electron diffraction and microscopy.
Insulin Activity: The Solid Matrix (1973)

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Effects of shallow angle on static strength and fatigue life of multi-directional laminates for wind turbine blades (2016)

The effects of the shallow angle on the static strength and the fatigue life of the multi-directional glass fiber-reinforced plastics for wind turbine blades were presented based on experimental results and predictions. The static tests and the tension–tension fatigue tests under cyclic fatigue loads with a stress ratio of 0.1 were performed on bi-axial (BX, [±θ]), tri-axial 1 (TA, [0/±θ 2 ]), and tri-axial 2 (TX, [0 2 /±θ]) laminates with ply angles θ of 25°, 35°, and 45°. A multiscale approach was applied to predict the static tensile and compressive strengths and the S–N curves of BX, TA, and TX laminates based on the constituents: fiber, matrix, and interface. Three ply-based failure criteria (Hashin, Puck, and Tsai–Wu) were also employed to predict the static strength and compare with the experimental results. The predictions and the experimental results show that the tensile strength increases as θ becomes shallower, while laminates with a shallow ply angle of 35° showed similar or even lower compressive strengths, especially for TA and TX laminates. The laminate fatigue life increases as θ becomes shallower. The shallow angle effect on strength and fatigue life is greater for BX than TA and TX laminates since the ply angle θ plays a more important role in BX. By using the multiscale approach, the shallow angle effect on the laminate static and fatigue behaviors were also explained based on the ply stresses as well as the constitutive micro stresses.
Toward accurate and practical network tomography (2013)

research-article Share on Toward accurate and practical network tomography Authors: Denisa Ghita EPFL, Switzerland EPFL, SwitzerlandView Profile , Katerina Argyraki EPFL, Switzerland EPFL, SwitzerlandView Profile , Patrick Thiran EPFL, Switzerland EPFL, SwitzerlandView Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 47Issue 1January 2013 pp 22–26https://doi.org/10.1145/2433140.2433146Online:29 January 2013Publication History 10citation257DownloadsMetricsTotal Citations10Total Downloads257Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Une Approche Intégrée pour Résoudre le Problème de Formation des Cellules de Production avec des Routages Alternatifs (2003)

Dans cet article, nous traitons les problèmes de formation de cellules en présence de routages alternatifs et de contraintes de capacité au niveau des machines. Connaissant la capacité des machines, le processus de fabrication des produits et les quantités à produire, le problème consiste à choisir, pour chaque produit, le routage préférentiel qui permettra d’optimiser la mise en cellule en terme de trafic intercellulaire. L’objectif principal est de minimiser ce trafic en respectant les contraintes de capacité. Nous proposons une approche basée sur l’intégration d’un algorithme génétique de groupement multi-objectifs pour la formation des cellules dans un premier algorithme génétique de groupement multi-objectifs pour le choix du routage préférentiel (en résolvant un problème associé de resource planning).
Quantitative Description of the Effect of Molecular Size upon Electroosmotic Flux Enhancement during Iontophoresis for a Synthetic Membrane and Human Epidermal Membrane (1996)

This study focused upon quantitatively determining the influence of permeant molecular size upon flux enhancement which results from electroosmosis. The first phase of the study involved validation of a fundamental model describing the molecular size dependence of flux enhancement which results from convective solvent flow. This was accomplished using a model synthetic membrane (stack of 50 Nuclepore membranes) and four model permeants with a molecular weight range of 60-504 (urea, mannitol, sucrose, and raffinose). The steady-state flux of each permeant was determined under passive conditions and applied voltages of 125, 250, 500, and 1000 mV using side-by-side diffusion cells and a four-electrode potentiostat system. On the basis of the permeability enhancement for each permeant at each applied voltage (relative to the passive permeability) it was possible to calculate the effective solvent flow velocity from each permeant at each field strength. An important finding was that the flux enhancement due to electroosmosis was strongly molecular weight dependent (i.e., the flux enhancement ratio was around 4 times greater for raffinose than for urea, with mannitol and sucrose yielding intermediate values), while the calculated effective flow velocity at each voltage was independent of the molecular weight of the permeant. This coupled with a linear correlation between flow velocity and applied voltage served to establish the validity of the method and model. The second phase of the study was an extension of the model to human epidermal membrane (HEM). These experiments involved simultaneously measuring the fluxes of [14C]urea and [3H]sucrose across HEM samples under passive, 250 mV, and 500 mV conditions. Similar to the Nuclepore system, the observed flux enhancement ratios with HEM were approximately 3 times greater for sucrose than for urea. A detailed analysis of the HEM data showed semiquantitative agreement between predictions of the model and experimental results.
A Work-Based Window Method for Calculating In-Use Brake-Specific NOx Emissions of Heavy-Duty Diesel Engines (2008)

&lt;div class="htmlview paragraph"&gt;A work-based window method has been developed to calculate in-use brake-specific oxides of nitrogen (NOx) emissions for all engine speeds and engine loads. During an in-use test, engine speed and engine torque are read from the engine's electronic control unit, and along with time, are used to determine instantaneous engine power. Instantaneous work is calculated using this power and the time differential in the data collection. Work is then summed until the target amount of work is accumulated. The emissions levels are then calculated for that window of work. It was determined that a work window equal to the theoretical Federal Test Procedure (FTP) cycle work best provides a means of comparison to the FTP certification standard. Also, a failure criterion has been established based on the average amount of power generated in the work window and the amount of time required to achieve the target work window to determine if a particular work window is valid.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Data collected during Phase IV of West Virginia University's in-use testing program were used to show that the work window method produces in-use brake-specific NOx values similar to the 30 second Not-To-Exceed (NTE) window method, which was applicable at the time of testing, and the continuous NTE window method over different highway and urban test routes for a variety of engine configurations.&lt;/div&gt;
ChemInform Abstract: Nucleotides. Part 28. Chemical Syntheses of the 2′‐5′‐Cordycepin‐Trimer Core (I). (1988)

Abstract The synthesis of the title compound (I) is described by three different routes using various protecting groups and applying the phosphotriester approach.