gebhart/patrepeval huggingface dataset:
Enhancing Performance of a GaAs/AlGaAs/GaAs Nanowire Photodetector Based on the Two-Dimensional Electron–Hole Tube Structure (2020)

Here, we design and engineer an axially asymmetric GaAs/AlGaAs/GaAs (G/A/G) nanowire (NW) photodetector that operates efficiently at room temperature. Based on the I-type band structure, the device can realize a two-dimensional electron-hole tube (2DEHT) structure for the substantial performance enhancement. The 2DEHT is observed to form at the interface on both sides of GaAs/AlGaAs barriers, which constructs effective pathways for both electron and hole transport in reducing the photocarrier recombination and enhancing the device photocurrent. In particular, the G/A/G NW photodetector exhibits a responsivity of 0.57 A/W and a detectivity of 1.83 × 10<sup>10</sup> Jones, which are about 7 times higher than those of the pure GaAs NW device. The recombination probability has also been significantly suppressed from 81.8% to 13.2% with the utilization of the 2DEHT structure. All of these can evidently demonstrate the importance of the appropriate band structure design to promote photocarrier generation, separation, and collection for high-performance optoelectronic devices.
Concrete Reinforcement with Recycled Fibers (2000)

Fiber reinforcement can effectively improve the toughness, shrinkage, and durability characteristics of concrete. The use of recycled fibers from industrial or postconsumer waste offers additional advantages of waste reduction and resources conservation. This paper reviews some of the work on concrete reinforcement using recycled fibers, including tire cords/wires, carpet fibers, feather fibers, steel shavings, wood fibers from paper waste, and high density polyethylene. This paper also provides a summary of the properties and applications of concrete reinforced with these fibers.
Math3andNeuroDregulate amacrine cell fate specification in the retina (2002)

The basic helix-loop-helix genes Math3 and NeuroD are expressed by differentiating amacrine cells, retinal interneurons. Previous studies have demonstrated that a normal number of amacrine cells is generated in mice lacking either Math3 or NEUROD: We have found that, in Math3-NeuroD double-mutant retina, amacrine cells are completely missing, while ganglion and Müller glial cells are increased in number. In the double-mutant retina, the cells that would normally differentiate into amacrine cells did not die but adopted the ganglion and glial cell fates. Misexpression studies using the developing retinal explant cultures showed that, although Math3 and NeuroD alone only promoted rod genesis, they significantly increased the population of amacrine cells when the homeobox gene Pax6 or Six3 was co-expressed. These results indicate that Math3 and NeuroD are essential, but not sufficient, for amacrine cell genesis, and that co-expression of the basic helix-loop-helix and homeobox genes is required for specification of the correct neuronal subtype.
Supplementary Figure 3 from Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results (2023)

&lt;p&gt;Serial measures of absolute neutrophil count (ANC), hemoglobin (Hgb) and platelet counts (PLT) through complete pacritinib treatment period&lt;/p&gt;
A tetranucleotide repeat for the F13B locus (1992)

Journal Article A tetranucleotide repeat for the F13B locus Get access D.Y. Nishimura, D.Y. Nishimura 140C EMRB, University of IowaIowa City, IA 52242, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J.C. Murray J.C. Murray 140C EMRB, University of IowaIowa City, IA 52242, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 5, 11 March 1992, Page 1167, https://doi.org/10.1093/nar/20.5.1167-a Published: 11 March 1992
Impairments in odour detection and hedonic ratings of unpleasant smells in asymptomatic university students as SARS‐Cov‐2 emerged locally (2021)

Sudden olfactory loss in the absence of concurrent nasal congestion is now a well-recognized symptom of COVID-19. We examined olfaction using standardized objective tests of odour detection, identification and hedonics collected from asymptomatic university students before and as SARS-CoV-2 emerged locally. Olfactory performance of students who were tested when the virus is known to be endemic (n = 22) was compared to students tested in the month prior to viral circulation (n = 25), a normative sample assessed during the previous 4 years (n = 272) and those tested in prior years during the same time period. Analyses showed significantly reduced odour detection for the virus exposed cohort compared to students tested before (t = 2.60; P = .01; d = 0.77; CI 0.17, 1.36) and to the normative sample (D = 0.38; P = .005). Odour identification scores were similar, but the exposed cohort rated odours as less unpleasant (P < .001, CLES = 0.77). Hyposmia increased 4.4-fold for students tested 2 weeks before school closure (N = 22) and increased 13.6-fold for students tested in the final week (N = 11). While the unavailability of COVID-19 testing is a limitation, this naturalistic study demonstrates week-by-week increase in hyposmia in asymptomatic students as a virus was circulating on campus, consistent with increasing airborne viral loads. The specific hedonic deficit in unpleasantness appraisal suggests a deficit in the TAAR olfactory receptor class, which conveys the social salience of odours. Assessment of odour detection and hedonic ratings may aid in early detection of SARS-CoV-2 exposure in asymptomatic and pre-symptomatic persons.
Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson’s disease (2021)

These results suggest that DBS-induced activation patterns revealed by fMRI contain predictive information with respect to the therapeutic and adverse effects of DBS. The use of fMRI in combination with DBS therefore may hold translational potential to guide and improve clinical stimulator optimization in patients.
Dengue virus persists and replicates during storage of platelet and red blood cell units (2016)

Both virus propagation and effects independent of cell function mitigate the intrinsic lability of DENV. Nevertheless, the overall rapid storage decay suggests that aged PLT and RBC units may be safer. These data raise awareness to the possible persistence of other conceivably more robust RNA viruses during the storage of cellular blood products.
Nanoparticle mediated RNA delivery for wound healing (2021)

Wound healing is a complicated physiological process that comprises various steps, including hemostasis, inflammation, proliferation, and remodeling. The wound healing process is significantly affected by coexisting disease states such as diabetes, immunosuppression, or vascular disease. It can also be impacted by age, repeated injury, or hypertrophic scarring. These comorbidities can affect the rate of wound closure, the quality of wound closure, and tissues' function at the affected sites. There are limited options to improve the rate or quality of wound healing, creating a significant unmet need. Advances in nucleic acid research and the human genome project have developed potential novel approaches to address these outstanding requirements. In particular, the use of microRNA, short hairpin RNA, and silencing RNA is unique in their abilities as key regulators within the physiologic machinery of the cell. Although this innovative therapeutic approach using ribonucleic acid (RNA) is an attractive approach, the application as a therapeutic remains a challenge due to site-specific delivery, off-target effects, and RNA degradation obstacles. An ideal delivery system is essential for successful gene delivery. An ideal delivery system should result in high bioactivity, inhibit rapid dilution, controlled release, allow specific activation timings facilitating physiological stability, and minimize multiple dosages. Currently, these goals can be achieved by inorganic nanoparticle (NP) (e.g., cerium oxide, gold, silica, etc.) based delivery systems. This review focuses on providing insight into the preeminent research carried out on various RNAs and their delivery through NPs for effective wound healing. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures.
Cross-Layer Signaling for Enhanced Wireless QoE (2018)

The paper proposes a novel cross-layer signaling mechanism to provide unprecedented Quality of Experience (QoE) in next generation mobile networks. The number of network-connected cameras is rapidly increasing, especially on the widely and globally deploying cellular networks (i.e. LTE). In many cases, the video traffic can be considered as a real-time traffic, as the video traffic generating service may require continuous real-time human interaction or may be a part of the remote control system. Meanwhile, throughput and delay can vary rapidly due to changes in a radio network, thus affecting service QoE. The novel cross-layer signaling mechanism presented requires minimal modification to the networking stack at the client side for faster feedback of wireless link capacity variations. The proposed mechanism has been evaluated via simulation with video traffic. The results show outage rate decreased from 1.3 outages/sec to zero and reduction in self-inflicted delay, from 60 ms to 14 ms.
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli (1993)

Lipocortin or annexin 1 is a calcium-dependent phospholipid-binding protein which probably acts as a glucocorticoid- regulated anti-inflammatory factor. cDNA for human lipocortin 1 was cloned in the pT7.7 expression plasmid under the control of the inducible bacteriophage T7 RNA polymerase promoter. Upon induction with isopropyl thio-beta-D-galactoside, large amounts of the protein were produced and accumulated in Escherichia coli in a soluble form. The recombinant protein was purified to homogeneity by means of two subsequent ion-exchange chromatographic steps. The final yield was about 30 mg/l bacterial culture. Electrospray mass spectrometric analysis of the purified protein demonstrated that the recombinant product corresponds to the native human lipocortin 1, without the initial methionine and with a free N-terminal alanine; tryptic peptide mapping by fast-atom-bombardment mass spectrometry showed that the recombinant protein contains cysteine residues at positions 263 and 324 with free thiol groups, whereas Cys270 and Cys343 are probably involved in an intrachain disulfide bridge. Recombinant human lipocortin 1 reduces the carrageenin-induced paw oedema in rat in vivo and inhibits porcine pancreatic phospholipase A2 activity in vitro; in both cases, a dose-related response is observed.
Advances in Physical Ergonomics & Human Factors Proceedings of the AHFE 2018 International Conference on Physical Ergonomics & Human Factors, July 21-25, 2018, Loews Sapphire Falls Resort at Universal Studios, Orlando, Florida, USA (2018)

Design Process for an Ergonomic Solution to The Police Officer Duty Belt -- Rethinking Ergonomics Design -- Ergonomic Design Solution for Reducing Smoke Build-Up Inside Rural Kitchens in Kenya -- Steel Surface Defects Detection Based on Deep Learning -- Ergonomic Work Analysis at Plant Nurseries of a Portuguese Municipality -- Study on Upper Limb Reachable Threshold in Driving Posture -- Stress at Work and Physical Load in Professional Sport -- Research on the Contact Force of Fingers When Grasping Bottles -- Evaluation of Worker Satisfaction with the Use of Hand Tools in a Poultry Slaughterhouse -- Effects of Upper Limb Fatigue on Gait Stability.
New Treatment Approaches to Arteriovenous Malformations (2017)

Arteriovenous malformations (AVMs) are high-flow vascular anomalies that have demonstrated a very high recurrence rate after endovascular treatment, surgical treatment, or a combination of both. Surgical treatments have shown good response when they are small and well localized but a poor response when diffuse. A better understanding of the nature of the lesion has led to a better response rate and a safer treatment for these patients. This has been accomplished through a detailed understanding of the angioarchitecture of the lesion, enabling a tailored approach in reaching and targeting the nidus of the AVM with different liquid embolic agents, more specifically ethanol. Flow reduction techniques help in exposing the nidus to sclerosant agents. A clinical classification, the Schobinger classification, will help determine the appropriate time to start or to pursue therapy.
Microfluidic techniques for separation of bacterial cells via taxis (2020)

The microbial environment is typically within a fluid and the key processes happen at the microscopic scale where viscosity dominates over inertial forces. Microfluidic tools are thus well suited to study microbial motility because they offer precise control of spatial structures and are ideal for the generation of laminar fluid flows with low Reynolds numbers at microbial lengthscales. These tools have been used in combination with microscopy platforms to visualise and study various microbial taxes. These include establishing concentration and temperature gradients to influence motility via chemotaxis and thermotaxis, or controlling the surrounding microenvironment to influence rheotaxis, magnetotaxis, and phototaxis. Improvements in microfluidic technology have allowed fine separation of cells based on subtle differences in motility traits and have applications in synthetic biology, directed evolution, and applied medical microbiology.
Effects of 2 Different Anti–Tumor Necrosis Factor–α Agents in a Primate Model of Subcutaneous Abscess Formation (2002)

Tumor necrosis factor (TNF)-alpha exerts both physiologic and pathologic effects in response to infection, conferring the benefit of host defense against infection at the risk of eliciting severe pathology if the response is excessive or inappropriate. In the present study, the effects of an anti-TNF-alpha monoclonal antibody (MAb) and a TNF-alpha receptor construct (p75-Fc) were compared with that of saline in a primate model of subcutaneous abscess induced with Staphylococcus aureus. Intravenous administration of anti-TNF-alpha MAb delayed the onset and reduced the incidence and the severity of abscess formation in response to inoculation with S. aureus at concentrations of 10(9) and 10(10) cfu/mL, compared with administration of saline. In contrast, no improvement in abscess formation was observed in animals treated with p75-Fc. These results supply initial evidence that anti-TNF-alpha MAb, unlike p75-Fc, provides a beneficial effect in this abscess model.
Comparison of an extented database for flow boiling heat transfer coefficients in multi-microchannels elements with the three-zone model (2005)

LTCM
A 106-Gb/s PAM-4 Silicon Optical Receiver (2019)

We present a 106-Gb/s four-level pulse-amplitude modulation (PAM-4) silicon optical receiver consisting of a low-noise fully differential transimpedance amplifier (TIA) wirebonded to a high-speed silicon photonic Ge photodiode (PD). A low-noise operation is achieved through a fully differential TIA architecture, combined with active on-chip biasing for the PD. To the best of our knowledge, this is the first integrated low-power optical receiver to report (sub-)KP4-FEC bit error ratios up to 53 GBd PAM-4 without any digital signal processing or equalization to compensate the receiver. An optical modulation amplitude sensitivity of -5 dBm at 53 GBd is obtained, while consuming 160 mW (1.51 pJ/b at 53 GBd). The receiver achieves the best-reported sensitivities from 32- up to 53-GBd PAM-4, at the lowest reported power consumption.
Euler-Lagrange modeling and passivity based control of Buck converters with input filter (2011)

International audience
Supplementary Figure 2 from Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade (2023)

&lt;p&gt;PDF file - 93K, Fig. S2. NK cells from melanoma patients down-regulate the expression of cytokine receptors, rendering them refractory to cytokine stimulation.&lt;/p&gt;
Silver/(sub-10 nm)hafnium-oxide-based resistive switching devices on silicon: characteristics and switching mechanism (2020)

This study investigates the resistive switching (RS) behavior of Ag/HfO<sub>2</sub>(3 nm-thick)/SiO <sub>x</sub> (interfacial-layer)/Si devices. The findings are drawn from a systematic electrical and material characterization of the fabricated devices. Based on the current-time (I-t) and current-voltage (I-V) measurements, it is inferred that both metal and oxygen ion migration play a significant role in the switching events, leading to bipolar and unipolar switching modes depending on the biasing scheme. The results demonstrate two competing switching mechanisms taking place when the biasing voltage is increased beyond the RESET voltage in the bipolar mode. The devices are also shown to exhibit self-rectifying characteristics when the bias is applied to the Ag electrode. The proposed method of investigating the total charge passed through the device within the time to SET, during the I-t characterization, is particularly useful for identifying the current transport models governing the high-resistance state. The results reported in this manuscript provide useful insights into the control of RS behavior in this scientifically and technologically important material system. Developing a thorough understanding of the fundamental physics governing the observed RS behavior is a substantial step for the growing progress in the memristor device research, as well as for its potential exploitation in diverse CMOS-compatible applications.
DNA methylation profile, histone modification code and CTCF content within aberrantly silenced vs. transcriptionally active human von Hippel-Lindau disease (VHL) Locus. (2004)

3628 Kruppel-like transcription factors have been linked to cell growth regulation and tumorigenesis in a number of systems. In the intestinal epithelium, expression of KLF5 (IKLF/BTEB2) is limited to proliferating crypt cells, indicating a growth promoting role. However, we have found that, while KLF5 is growth promoting in non-transformed intestinal epithelial cells, it is growth inhibitory in colon tumor-derived and transformed cells, indicating that this factor has both growth promoting and tumor suppressive properties in the intestine. This idea is consistent with our previous observation that KLF5 mRNA is downregulated in APCmin mouse and human familial adenomatous polyposis adenomas. A tumor suppressive role for KLF5 is likely to be common in epithelial cancers since this factor has been implicated as a tumor suppressor in prostate and breast, where its gene locus at chromosome 13q21 is commonly deleted. While deletion of this chromosome region is found in multiple cancer types, it is not observed in colon cancer, pointing to other mechanisms for downregulation of KLF5 in intestinal tumors. One mechanism involves downregulation of KLF5 mRNA which correlates with enhanced cell growth and tumorigenicity in the HCT116/HCT116B syngeneic colon cancer cell lines. However, analysis of other colon tumor cell lines and a syngeneic model of intestinal tumor progression indicated that loss of mRNA could not fully account for the loss of KLF5 protein, pointing to post-translational mechanisms of downregulation during tumor progression. Use of the proteasome inhibitor, MG132 indicated that this involves enhanced turnover of the protein. High levels of proteasome-dependent downregulation were seen in all human colon cancer cells tested, but not in non-transformed intestinal epithelial cells, indicating that it is a common mechanism for KLF5 loss during colon cancer progression. The utilization of multiple mechanisms for downregulation of KLF5 emphasizes the importance of reduced expression of this factor in intestinal tumorigenesis and points to potential targets for therapy. This work was supported by the Roswell Park Alliance foundation and the Roswell Park CCSG core grant CA16056.
An improved colour detection method in skin lesions using colour enhancement (2015)

Colour information plays an important role in classifying skin lesions. A critical step in analysing dermoscopic skin lesion images is accurate classification of the lesion colours. It is common knowledge that different photographic devices or different illumination will lead to different image colours of the same lesion and hence create difficulties in the detection of colours. Similarly, low contrasts make accurate colour detection difficult. In this paper, we investigate and provide solutions to the problems of poor contrast and lack of colour enhancement in skin lesion classification. This is done by combining colour enhancement with automatic colour identification, which is based on imitating the human perception of colours in skin lesions. The combined colour contrast enhancement and automatic colour identification method consists of four main steps: (i) the RGB dermoscopy image is transformed to CIE L*a*b* colour space, (ii) lesion contrast is then enhanced by adjusting and mapping the intensity values of the lesion pixels using combined top-hat and bottom-hat morphological filter, (iii) QuadTree decomposition technique is applied on the enhanced images, and (iv) each block of QuadTree segmented image is assigned to its closest colour patch from the colour palette. Our results show that contrast enhancement improves the classification of dermoscopy images by increasing the sensitivity of the automatic colour detection system from 93.2% to 93.9% and the specificity from 84.4% to 89.1%.
ROS-IvP: Porting the Interval Programming suite into the Robot Operating System for maritime autonomy (2016)

We present a set of software packages that integrates the arbitration framework, user interface utilities, and native vehicle behaviors found in the Mission-Oriented Operating Suite (MOOS-IvP) into the Robot Operating System. MOOS-IvP is prevalent in the maritime robotics community due to a large library of maritime-specific autonomy behaviors, interfaces to common unmanned underwater vehicles, utility programs, and the inclusion of a default arbitration framework for autonomous decision making. However, the Robot Operating System (ROS) has grown in use within the autonomy and robotics communities at large due to the utility of its communications framework, node introspection capabilities, and messaging architecture. In our work we combine the best capabilities of both robotics architectures into two packages for use in maritime autonomy applications. The packages allow introspection of the various components of the IvP autonomy framework and allow behaviors to be backwards-compatible with standard MOOS-IvP.