gebhart/patrepeval huggingface dataset:
Replacement of bovine serum albumin withN‐methyl‐D‐aspartic acid and homocysteine improves development, but not live birth (2012)

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69‐4: Invited Paper: A Programmable Capacitive Imaging Technique Using Multiple Sigma‐Delta Modulators for High SNR Touch Sensor and Pen (2018)

A capacitive sensing technique based on sigma‐delta modulation is presented. This architecture creates multi‐frequency drive and sense signals with high SNR. It enables concurrent and simultaneous self‐capacitive touch, mutual‐capacitive touch and capacitive pen.
Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema (2015)

This study characterizes the kallikrein-kinin system in vitreous from individuals with diabetic macular edema (DME) and examines mechanisms contributing to retinal thickening and retinal vascular permeability (RVP). Plasma prekallikrein (PPK) and plasma kallikrein (PKal) were increased twofold and 11.0-fold (both P < 0.0001), respectively, in vitreous from subjects with DME compared with those with a macular hole (MH). While the vascular endothelial growth factor (VEGF) level was also increased in DME vitreous, PKal and VEGF concentrations do not correlate (r = 0.266, P = 0.112). Using mass spectrometry-based proteomics, we identified 167 vitreous proteins, including 30 that were increased in DME (fourfold or more, P < 0.001 vs. MH). The majority of proteins associated with DME displayed a higher correlation with PPK than with VEGF concentrations. DME vitreous containing relatively high levels of PKal and low VEGF induced RVP when injected into the vitreous of diabetic rats, a response blocked by bradykinin receptor antagonism but not by bevacizumab. Bradykinin-induced retinal thickening in mice was not affected by blockade of VEGF receptor 2. Diabetes-induced RVP was decreased by up to 78% (P < 0.001) in Klkb1 (PPK)-deficient mice compared with wild-type controls. B2- and B1 receptor-induced RVP in diabetic mice was blocked by endothelial nitric oxide synthase (NOS) and inducible NOS deficiency, respectively. These findings implicate the PKal pathway as a VEGF-independent mediator of DME.
Decontamination of Nitrate Polluted Water (1987)

Abstract Nitrate can be extracted from water at any pH below 10 by a water-insoluble quaternary ammonium 2, 4, 6-tri-methylphenate or N-benzyl-H-methylbenzenesulfonamidate dissolved in trioctylphosphate (TOP). Membranes were prepared by taking up TOP solutions of the quaternary ammonium bases in porous polypropylene (CelgardR-2400). These membranes were used in a modified dialysis cell to transfer N03 − from near-neutral water to stripping solutions of pH, 12–14. Specific rate constants, k, in excess of 10−4 cm s−1 were observed for nitrate removal under a wide variety of loading and stripping conditions. This is sufficient to project a practical device for the decontamination of nitrate-polluted water. When the hydrodynamic resistances in both the feed and the strip are removed by pumping these solutions through static mixers adjacent to the membrane, K is reduced by making the stripping solution less basic or by increasing its nitrate concentration. These observations suggest that the disassembly of the carrier of the N03 − and H+ at the stripping interface is a step-wise process, involving energetically unfavorable, charge-separated species.
Veränderungen des immunologischen Status bei Patienten mit „late-onset“-Primär Sklerosierender Cholangitis (PSC) (2015)

Einleitung: Die Primär Sklerosierende Cholangitis (PSC) ist eine chronsiche cholestatische Lebererkrankung. Der durchschnittliche Erkrankungsbeginn liegt zwischen dem zwanzigsten und vierzigsten Lebensjahr. Kürzlich konnten wir eine verringerte Transplantations-freie Überlebenszeit in PSC-Patienten mit einem Erkrankungsbeginn nach dem fünfzigsten Lebensjahr nachweisen. Im Rahmen der aktuellen Studie möchten wir zugrunde liegende immunologische Veränderungen zwischen PSC-Patienten mit frühem und späten Erkrankungsbeginn untersuchen.
Clinical effects of chemoimmunotherapy for patients with peritoneal carcinomatosis (1997)

The present study was undertaken to determine whether chemoimmunotherapy using activated killer cells is better than chemotherapy alone for cancer patients with peritoneal carcinomatosis. Thirty-one cancer patients received adoptive immunotherapy by activated killer cells and chemotherapy by anticancer drugs selected by a chemosensitivity test (chemoimmunotherapy group), and another 31 cancer patients received chemotherapy (chemotherapy group). The regimen of chemotherapy was determined by the results of a chemosensitivity test in both groups. The clinical effects including response rate and survival were assessed. Five patients (16.1%) achieved complete response (CR), and 17 patients (54.8%) partial response (PR) in the chemoimmunotherapy group (response rate: 22/31 patients = 71.0%), whereas 4 patients (12.9%) achieved CR, and 5 patients (16.1%) PR in the chemotherapy group (response rate: 9/31 patients = 29.0%). The response rate was higher in chemoimmunotherapy group than in chemotherapy group (p<0.05). However, no difference was observed in survival between the two groups. Therefore, it is necessary to develop methods to induce more potent killer cells for adoptive immunotherapy.
4,5 disubstituted acridones with high selectivity for telomeric G-quadruplex and low toxicity in normal cells (2007)

4740 Telomerase is an enzyme expressed in around 90% of cancer cells. We are studying approaches to telomerase inhibition as an anticancer strategy that targets its substrate, 3’-end single-stranded telomeric DNA. Telomerase does not recognise the substrate when it is folded into a G-quadruplex structure. The formation in vivo and ligand-mediated stabilisation of these structures would effectively inhibit telomerase. We have designed and synthesised a diverse library of 4,5-disubstituted compounds based on the acridone core and evaluated them as G-quadruplex stabilising agents (by fluorescence resonance energy transfer assay, FRET), telomerase inhibitors (with the telomeric repeat amplification protocol assay, TRAP) and as anticancer agents (by cell culture studies). Furthermore, we have also carried out molecular modelling studies in order to identify the mode of binding to the quadruplex and also calculated their binding energies using MM-PBSA method. A particular group of features confers to these molecules potency and selectivity towards the G-quadruplex DNA. The results from the biophysical assays and cell culture studies support this hypothesis. The DNA melting experiments showed a degree of stabilisation for the G-quadruplex DNA comparable to the most potent existing ligands but only very low affinity for duplex DNA. The values of telomerase inhibition correlated well with the DNA melting experiments and the most potent compounds were in the low micromolar range. In the short term cell culture experiments most compounds showed selective toxicity towards the cancer cell lines (MCF7 and A549) when compared with a somatic one (IMR90). The long-term studies for a number of compounds showed effects on cell proliferation at concentrations below those required for short-term cell kill and no sign of resistance.
Semi-supervised Learning of a Markovian Metric (2008)

The role of a distance metric in many supervised and semi-supervised learning applications is central in the success of clustering algorithms. Since existing metrics like Euclidean do not necessarily reflect the true structure (clusters or manifolds) in the data, it becomes imperative that an appropriate metric be somehow learned from training or labeled data. Metric learning has been a relatively new topic in data mining and machine learning, though most work that deals with this topic learns a suitable linear transformation of the original data. This transformation is usually learned using training data and has been shown to improve test data classification accuracy. In this paper we present a Markov random walk based semi-supervised method for metric learning. Our method differs from the aforementioned techniques in that we use minimal labeled data and we do not assume any Mahalanobis type metric structure on the data. We create a computationally efficient nearest neighbor graph representation of the data and pose a semidefinite program that learns the random walk on the associated graph. This is used to generate a distance measure between all unlabeled points and the performance is compared against other important metrics using the k-NN classification rule.
Chemical Alignment of DNA Origami to Block Copolymer Patterned Arrays of 5 nm Gold Nanoparticles (2011)

We have used block copolymer patterned arrays of 5 nm gold nanoparticles (AuNPs) for chemically aligned surface attachment of DNA origami. Addition of single-stranded DNA-thiol to AuNPs allowed a base paired attachment of sticky end modified DNA origami. Results indicate a stable, selective attachment between the DNA origami and ssDNA modified AuNPs. Yield data showed 74% of AuNP binding sites forming an attachment with a DNA origami rectangle, and control surfaces showed less than 0.5% nonspecific adsorption.
Méthodologie de conception d'amplificateurs faible niveau à haute linéarité en technologie MMIC pour récepteur satellite (2009)

National audience
Flexible microwave ablation applicator for the treatment of pulmonary malignancies (2017)

Microwave ablation (MWA) is an emerging minimally invasive treatment option for malignant lung tumors. Compared to other energy modalities, such as radiofrequency ablation, MWA offers the advantages of deeper penetration within high impedance tissues such as aerated lung, shorter treatment times, and less susceptibility to the cooling heat-sink effects of air and blood flow. Previous studies have demonstrated clinical use of MWA for treating lung tumors; however, these procedures have relied upon the percutaneous application of rigid microwave antennas. The objective of our work was to develop and characterize a novel flexible microwave applicator which could be integrated with a bronchoscopic imaging and software guidance platform to expand the use of MWA as a treatment option for small (&lt; 2cm) pulmonary tumors. This applicator would allow physicians an even less invasive, immediate treatment option for lung tumors identified within the scope of current medical procedures. It may also improve applicator placement accuracy and increase efficacy while minimizing the risk of procedural complications. A 2D-axisymmetric coupled FEM electromagnetic-heat transfer model was implemented to characterize expected antenna radiation patterns, ablation size and shape, and optimize antenna design for lung tissue. A prototype device was fabricated and evaluated in ex vivo tissues to verify simulation results and serve as proof-of-concept. Additional experiments were conducted in an in vivo animal model to further characterize the proposed system.
Novel performance optimization of large-scale discrete-event simulation on the Cell Broadband Engine (2010)

This paper presents a computing technique for efficient parallel simulation of large-scale discrete-event models on the IBM Cell Broadband Engine (CBE), which has one Power Processor Element (PPE) and eight Synergistic Processing Elements (SPE). Based on the general-purpose Discrete Event System Specification (DEVS), the technique tackles all performance bottlenecks, combining multi-dimensional parallelism and various optimizations. Preliminary experiments have produced very promising results, attaining speedups up to 134.34 and 41.23 over the baseline implementation on PPE and on Intel Core2 Duo E6400 processor respectively. The methods can also be applied to other multicore and shared-memory architectures. We conclude that the technique not only allows discrete-event simulation users to tap CBE potential without being distracted by multicore programming, but also provides insight on migration of legacy software to current and future multicore platforms.
Reconstruction of Surfaces from Mixed Hydrocarbon and PEG Components in Water: Responsive Surfaces Aid Fouling Release (2012)

Coatings derived from surface active block copolymers (SABCs) having a combination of hydrophobic aliphatic (linear hydrocarbon or propylene oxide-derived groups) and hydrophilic poly(ethlyene glycol) (PEG) side chains have been developed. The coatings demonstrate superior performance against protein adsorption as well as resistance to biofouling, providing an alternative to coatings containing fluorinated side chains as the hydrophobe, thus reducing the potential environmental impact. The surfaces were examined using dynamic water contact angle, captive air-bubble contact angle, atomic force microscopy, X-ray photoelectron spectroscopy, and near-edge X-ray absorption fine structure analysis. The PS(8K)-b-P(E/B)(25K)-b-PI(10K) triblock copolymer precursor (K3) initially dominated the dry surface. In contrast to previous studies with mixed fluorinated/PEG surfaces, these new materials displayed significant surface changes after exposure to water that allowed fouling resistant behavior. PEG groups buried several nanometers below the surface in the dry state were able to occupy the coating surface after placement in water. The resulting surface exhibits a very low contact angle and good antifouling properties that are very different from those of K3. The surfaces are strongly resistant to protein adsorption using bovine serum albumin as a standard protein challenge. Biofouling assays with sporelings of the green alga Ulva and cells of the diatom Navicula showed the level of adhesion was significantly reduced relative to that of a PDMS standard and that of the triblock copolymer precursor of the SABCs.
Experimental Demonstration of 100/200-Gb/s/λ PON Downstream Transmission Using Simplified Coherent Receivers (2022)

We demonstrate 100- and 200-Gb/s/λ line-rate PON downstream transmission considering Alamouti-coded 16QAM signal with a single-polarization heterodyne receiver. The power budget is experimentally evaluated for both single-ended and balanced detection considering 25 km reach.
Photoconductive Nanotubes: Hexabenzocoronene Graphitic Nanotube Appended with Dithienylethene Pendants: Photochromism for the Modulation of Photoconductivity (Adv. Mater. 7/2010) (2010)

The front cover illustrates a novel photoconductive nanotube by self-assembly of a dithienylethene-appended hexa-peri-hexabenzocoronene, where the graphite-like nanotubular wall is laminated on both sides by densely packed dithienylethene pendants. The closed form of the photochromic pendant (green) serves as a better electron acceptor than its open form (yellow), so the photoconductivity of the nanotube can be modulated by photochemical isomerization of the pendants. More details can be found in the article by Takuzo Aida and co-workers on p. 829.
Mobile solid $^3$He on carbon nanotube promoted by topological frustration. (2020)

Low dimensional fermionic quantum systems are exceptionally interesting because they reveal distinctive physical phenomena, including among others, topologically protected excitations, edge states, frustration, and fractionalization. Two-dimensional $^3$He has indeed shown a remarkable variety of phases of matter including the unusual quantum spin liquid. Our aim was to lower the dimension of the $^3$He system even more by confining it on a suspended carbon nanotube. We demonstrate that $^3$He on a nanotube merges both fermionic and bosonic phenomena, with a quantum phase transition between solid 1/3 phase and a fluid-like solid. The bosonic dimer fluid-like solid contains topology-induced vacancies which are delocalized owing to large zero-point motion. We thus observe a quantum phase transition from fermionic $^3$He crystal in to a bosonic one in quasi-1D geometry.
<title>Optimality of SCS watermarking</title> (2003)

Blind spread-spectrum watermarking schemes with correlation based detection algorithms suffer significantly from host signal interference. Improvements are possible when considering the host signal as side-information to the watermark encoder. Costa showed that, in a specific case, host signal interference can be avoided completely. The scalar Costa scheme, which operates on structured codebooks based on scalar quantizers, performs relatively close to the ideal Costa scheme in terms of maximum rate of reliable communication (capacity) over a channel with AWGN attack. The concept of amplitude limited channels in conjunction with repetition of the signal constellation is also known in the communications community by the name modulo channel, which has been studied into great detail. Starting from the modulo channel, which implies a constraint on the amplitude in the receiver, we model the watermarking scenario based on scalar quantizers. The capacity of this model is presented and compared to the theoretical results for SCS watermarking in the case of AWGN attacks. A final analysis of SCS in terms of optimality, based on the results with the modulo channel, shows that even binary SCS is near optimum for one-dimensional (symbol-by-symbol) embedding in terms of capacity for an i.i.d. Gaussian host signal and an appropriate AWGN attack.
Low-Power Resonant Acceleration Switch for Unattended Sensor Wake-Up (2018)

We have designed, built, and tested novel low-power (less than 10 nW) resonant acceleration switches. The switches respond to vibration at specifically designed frequencies between 30 and 1000 Hz by resonating with sufficient displacement to close an electrical contact and consume power only while vibration is occurring. A rotational design avoids switch closings from DC acceleration, and the quality factor, adjustable between 102 and 105 by tuning the vacuum level, sets the resonant detection threshold. The design includes electrostatic combs for selftest and frequency tuning (up to several Hz), compliant contacts to reduce squegging and contact damage, and ruthenium-coated contacts for improved reliability. Fabrication is accomplished with deep reactive ion etching at up to 50:1 aspect ratios, HF vapor release, and XeF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> frequency trimming (up to 30% of the as-fabricated frequency). Testing with vibration recordings played back through a shaker table demonstrates that the switches correctly identify a target without any false alarms.
Efficient tunable UV pulse generation from a green pumped fs-OPCPA (2021)

High energy tunable ultrafast UV pulses are of great interest for a variety of applications. These pulses are also required for high repetition rate, fully coherent UV seeded free electron lasers [1] . In the absence of proper laser gain materials, optical parametric chirped pulse amplification (OPCPA) is considered as a foremost technique to generate high power tunable ultra-short laser pulses in various spectral ranges [2] . A typical example is the broadband green pumped OPCPA system driven by frequency doubled Ytterbium based chirped pulse laser amplifiers (CPA). The excellent power scalability of the OPCPAs allows generation of multi-millijoule, few femtosecond pulses with hundreds of watts of average power harnessing high energy and repetition rate commercially available CPA pump systems [3] . The absence of proper nonlinear crystals hinders operating OPCPAs directly in the UV spectral range. Therefore, frequency doubling, tippling or quadrupling of conventional OPCPAs are the usual techniques of generating tunable UV pulses. However, these schemes suffer from the strong two-photon absorption, narrow phase matching bandwidth, and non-linear phase transfer to UV range. As a consequence, for ultra-short pulses the maximum conversion efficiency of such schemes is typically limited to below 10%, and usually accompanied by pulse compression complications.
Simulation of partially coherent imagery in the space and frequency domains and by modal expansion (1982)

Three methods of digital simulation of partially coherent imagery are presented and compared. The first method is a direct discretization of imaging equations. In the second, the computations are performed in the Fourier domain. The third method is based on a modal expansion of the imaging as an incoherent sum of a number of coherent modes; this allows full utilization of FFT algorithms. It is shown that when the imaging is of narrow point spread function, the modal expansion method is very efficient, especially for relatively high coherence. Examples of 1-D and 2-D images are shown.
ENERGY EFFICIENCY ASSESSMENT OF DATA CENTERS USING MEASUREMENT AND MANAGEMENT TECHNOLOGY (2021)

The energy efficiency of a data center (DC) is determined by implementation of best practices. One of the major costs to operate data centers is cooling power to maintain safe operating environment for servers and IT equipment (ITE). Power consumption in data centers is largely governed by the ITE power consumption and the power spent to maintain cooling that enable safe operating conditions for ITE. This chapter describe here a new monitoring solution based on spatial and temporal benchmarking of data center using the measurement and management technology (MMT) to drive toward quantitative measurement-driven DC best practice implementation. Simple energy efficiency metrics can be calculated from high spatial–temporal measurements that can be easily translated into best operating practices to improve energy efficiency recommendations. The measurement and recommendation methods apply both to legacy and newly designed data centers.