gebhart/patrepeval huggingface dataset:
A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network (2010)

Clinical evaluation of a young woman with subcutaneous fibrotic nodules, progressive distal joint contractures and marfanoid stature revealed a previously unrecognized fibrotic disorder characterized by several unique phenotypic features and some features overlapping with known disorders. Mutational analysis of the FBN1 and FBN2 genes excluded Marfan syndrome and congenital contractural arachnodactyly. MMP2 gene sequence analysis excluded multicentric osteolysis, nodulosis and arthropathy. The lack of mutations within the MAGP2 gene also excluded an MAGP2-associated disorder. In order to establish the mechanistic basis for the severe skin pathology noted in this patient, we performed transcriptional profiling of dermal fibroblasts, and candidate gene expression studies in conjunction with immunocytochemistry and cell-based and functional assays. Data from these experiments have further excluded any previously recognized fibrotic disorder and identified a unique pattern of gene expression in this patient consistent with progressive fibrosis. The pathogenic mechanisms included persistent proliferation of dermal fibroblasts in coexistence with a disarray of the microfibrillar network. Collagen accumulation, moreover, could be linked to extensive crosslinking resulting from increased activities of lysyl oxidases (LOX and LOXL), and lack of remodelling due to deficiencies in collagenolytic matrix metalloproteinases. The disorder may represent a novel syndrome in which transforming growth factor-β1-independent dermal fibrosis, unlike known microfibrillar disorders caused by single gene deficiencies, associates with a disarray of the microfibrillar network.
Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for severe acute respiratory syndrome coronavirus 2 patients (2020)

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread globally, resulting in declaration of pandemic emergency [1]. COVID-19 patients suffer from various symptoms of infection, including pneumonia, acute respiratory distress syndrome (ARDS) and sepsis. Some known antiviral drugs, including remdesivir, have been proposed as effective agents for the treatment of SARS-CoV-2 infection [2, 3]. Along with the development of potential therapeutics, there is urgency to mitigate the transmission and economic crisis of SARS-CoV-2 via identification of biomarkers that can rapidly indicate the severity of the disease in infected patients. Wnt ligands are secreted glycoproteins and their downstream signalling plays a pivotal role in embryonic development and tissue homeostasis. Wnt5a/Wnt11 can be used as potential ARDS biomarkers for SARS-CoV-2 patients <https://bit.ly/3lxEGRA> We thank the patients who participated in this study.
Design of ball-cage based miniature stroke for integration in a flexible actuator with thrust wire (2011)

Robotic technology is used widely today because of their advantages to support human operator. Robot systems have been used, not only for industrial processes, but also for a wide range of applications, such as minimally invasive surgery. To perform complicated surgical operation with robot system, the flexible actuator which is composed of a linear motor and a thrust wire, has been proposed. From the previous research, the force transmissibility of the trust wire is evaluated. It seems that the performance of the flexible actuator depends on a shape changes of thrust wire. This is because, a thrust wire has friction effect. This paper deals with a new mechanical design of trust wire with the miniature stroke. The miniature stroke which is consists of a shaft, ball cage and nut, is applied in the flexible actuator to achieve high accuracy, minimal rolling loss and rolling motion with extremely low friction resistance. By using the proposed method, the improvement of position response and force sensation can be obtained. The effectiveness of the proposed method is verified by the friction force identification.
Critical Technical Issues in High Voltage SiC Power Devices (2008)

In this paper, we review the state of the art of SiC switches and the technical issues which remain. Specifically, we will review the progress and remaining challenges associated with SiC power MOSFETs and BJTs. The most difficult issue when fabricating MOSFETs has been an excessive variation in threshold voltage from batch to batch. This difficulty arises due to the fact that the threshold voltage is determined by the difference between two large numbers, namely, a large fixed oxide charge and a large negative charge in the interface traps. There may also be some significant charge captured in the bulk traps in SiC and SiO2. The effect of recombination-induced stacking faults (SFs) on majority carrier mobility has been confirmed with 10 kV Merged PN Schottky (MPS) diodes and MOSFETs. The same SFs have been found to be responsible for degradation of BJTs.
FDTD investigation of the field distributions in rectangular hard waveguides (2002)

The authors study numerically the field distribution inside rectangular hard waveguides at the frequency at which the expected field distribution is uniform in the open region of the waveguides. The study is made by using the finite difference time domain techniques (FDTD) as described by Gwarek, Morawski and Mroczkowsk (IEEE Trans. MTT vol.41, no.2, p.311-17, 1993) and as implemented in the program V2D-Solver. The method is generally valid for arbitrary waveguide cross-sections, and is applied to rectangular waveguides with dielectrically coated E-plane walls, with strip-loaded dielectric walls, and with corrugated walls. The major interest is to see the effect of fringe fields around the metal strips and the corrugated ridges, and to study the variations of the field distribution with the strip/corrugation period and size of waveguide cross-sections. The strips are also modeled by using the asymptotic strip boundary condition. This was made possible by an extension of the V2D-Solver.
Deployable and Reconfigurable Miura-Ori Reflectarray for Mission-Flexible Satellite Applications (2021)

A novel foldable and reconfigurable reflectarray antenna (RA), operating at 8.425GHz for deep space communications based on an extended Miura-Ori origami pattern is presented. The aperture leverages the properties of subdivision and a folding feature to create a packable and reconfigurable antenna capable of changing its beam from a single pencil beam to a multi-beam aperture with beamsteering ability. A mechanical and theoretical EM analysis is carried out supported by a numerical algorithm using array theory. The results show that the proposed reflectarray can achieve a high packing efficiency of 92%. This RA provides a pencil beam in the broadside at (θ = 0°, ϕ = 0) in its flat configuration and multi-beam (dual, triple and quad-beams) depending on its folding angle. For CubeSat applications, the key advantages of this RA are its decreased stowage volume, reconfigurable EM performance, beamsteering capabilities, low fabrication cost, and reduced complexity.
Sub-Shot-Noise Transmission Measurement Enabled by Active Feed-Forward of Heralded Single Photons (2017)

The limit of precision in optical measurements is due to quantum fluctuations, which are governed by Poissonian statistics. With a clever setup, however, the authors achieve a precision in transmission measurements that beats this limit, without the selective analysis of recorded data (post-selection). This shows that the single-photon-detector approach, used by many groups worldwide, is viable for real-world optical quantum metrology, not just proof-of-principle tests. In turn, this demonstration unlocks an array of techniques for quantum-state engineering that crucially depend on single-photon detection.
Sleep-Disordered Breathing in Pregnancy (2006)

Complaints of sleep disturbance are common during pregnancy, and there are many factors that are likely contributors. Hormonal and biochemical changes and the physical effect of the enlarging uterus are all probable mechanisms. Emerging evidence suggests that sleep disordered breathing (SDB) is particularly prevalent during pregnancy, chiefly late pregnancy, and this may be a significant factor contributing to sleep disruption. Both the prevalence and severity of snoring increase progressively throughout pregnancy, with reported snoring being as high as 46% during the last trimester of pregnancy, and estimated prevalence of clinically significant SDB greater than 10%. Both epidemiological data and case reports of obstructive sleep apnoea (OSA) suggest that SDB in pregnancy has adverse effects on maternal health and fetal development. Upper airway flow limitation, which is the characteristic pattern of SDB in women with preeclampsia, leads to marked vascular reactivity, with associated increments in peripheral vascular resistance and systemic arterial blood pressure and suppression of maternal cardiac output. Sleep-induced maternal hemodynamic compromise in preeclampsia is associated with adverse fetal consequences.The use of low levels of nasal continuous positive airway pressure (nasal CPAP) during maternal sleep in preeclampsia effectively reverses the sleep-induced maternal hemodynamic consequences and may also improve fetal outcome.
Structural and silver/vanadium ratio effects on silver vanadium phosphorous oxide solution formation kinetics: Impact on battery electrochemistry (2014)

The detailed understanding of non-faradaic parasitic reactions which diminish battery calendar life is essential to the development of effective batteries for use in long life applications. The dissolution of cathode materials including manganese, cobalt and vanadium oxides in battery systems has been identified as a battery failure mechanism, yet detailed dissolution studies including kinetic analysis are absent from the literature. The results presented here provide a framework for the quantitative and kinetic analyses of the dissolution of cathode materials which will aid the broader community in more fully understanding this battery failure mechanism. In this study, the dissolution of silver vanadium oxide, representing the primary battery powering implantable cardioverter defibrillators (ICD), is compared with the dissolution of silver vanadium phosphorous oxide (Ag(w)VxPyOz) materials which were targeted as alternatives to minimize solubility. This study contains the first kinetic analyses of silver and vanadium solution formation from Ag0.48VOPO4·1.9H2O and Ag2VP2O8, in a non-aqueous battery electrolyte. The kinetic results are compared with those of Ag2VO2PO4 and Ag2V4O11 to probe the relationships among crystal structure, stoichiometry, and solubility. For vanadium, significant dissolution was observed for Ag2V4O11 as well as for the phosphate oxide Ag0.49VOPO4·1.9H2O, which may involve structural water or the existence of multiple vanadium oxidation states. Notably, the materials from the SVPO family with the lowest vanadium solubility are Ag2VO2PO4 and Ag2VP2O8. The low concentrations and solution rates coupled with their electrochemical performance make these materials interesting alternatives to Ag2V4O11 for the ICD application.
Preserving the character of perturbations in scaled pitch contours (2010)

The global and fine dynamic components of a pitch contour in voice production, as in the speaking and singing voice, are important for both the meaning and character of an utterance. In speech, for example, slow pitch inflections, rapid pitch accents, and irregular regions all comprise the pitch contour. In applications where all components of a pitch contour are stretched or compressed in the same way, as for example in time-scale modification, an unnatural scaled contour may result. In this paper, we develop a framework for scaling pitch contours, motivated by the goal of maintaining naturalness in time-scale modification of voice. Specifically, we develop a multi-band algorithm to independently modify the slow trajectory and fast perturbation components of a contour for a more natural synthesis, and we present examples where pitch contours representative of speaking and singing voice are lengthened. In the speaking voice, the frequency content of flutter or irregularity is maintained, while slow pitch inflection is simply stretched or compressed. In the singing voice, rapid vibrato is preserved while slower note-to-note variation is scaled as desired.
Erythropoietin Sensitizer — A Case Study (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Diquaternary structure-directing agents built upon charged imidazolium ring centers and their use in synthesis of one-dimensional pore zeolites (2005)

A series of diquaternary organo-cations, structure-directing agents (SDA), were prepared from imidazole rings connected by methylene chains of various lengths. These were tested in zeolite syntheses to determine if four different one-dimensional pore system zeolites (MTT, TON, MTW and ZSM-48) could accommodate the changes in the positioning of the imidazolium ring that bears the charged nitrogen. We were able to demonstrate that there is flexibility in the methylene chain length for all of the zeolites except MTT, which apparently has more rigid demands concerning the fit of the SDA. While subsequent calculations showed which chain lengths should provide better fits of the SDA within the MTT framework, the syntheses with these SDA still did not yield MTT phases. This raised some issues concerning the dominance of kinetic factors over our thermodynamic considerations in zeolite synthesis.
Graphene-based dipole antenna for a UHF RFID tag (2015)

This paper describes design and measurements of RFID tag built of a graphene-based dipole antenna and a chip operating in the UHF band in accordance with the EPC Global Class 1 Gen. 2 standard. Several tags have been constructed and tested with a standard RFID reader to reveal that each one is fully operational, but the interrogation range for the graphene-based circuits has been limited in comparison to copper antennae. This can be attributed to increased sheet resistance of a graphene layer. However, it seems that for applications were the read range is not crucial the novel antenna can be an alternative to more expensive circuits printed with silver-based inks.
Supplementary Figure S5 from Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer (2023)

&lt;p&gt;CRISPR-UMI analysis of screens performed in NCI-H1693 cells - related to Figure 5&lt;/p&gt;
Open-source versatile 3D-print animal conditioning platform design for in-vivo preclinical brain imaging in awake mice and anesthetized mice and rats (2022)

ABSTRACT Proper animal conditioning is a key factor in the quality and success of preclinical neuroimaging applications. We introduce an open-source easy-to-modify multi-modal 3D printable design for rodent conditioning for magnetic resonance imaging (MRI) or other imaging modalities. Our design can be used for brain imaging in anesthetized or awake mice and anesthetized rats. We show ease-of-use and reproducibility of subject conditioning with anatomical T2-weighted imaging for both mice and rats. We also demonstrate application of our design for awake fMRI in mice using both visual evoked potential and olfactory stimulation paradigms. In addition, we demonstrate that our proposed cradle design can be extended to multiple imaging modalities combining MRI, Positron emission tomography and X-ray computed tomography.
Autoimmunity and atopic dermatitis (2004)

Patients suffering from severe manifestations of atopy mount IgE autoantibodies against a variety of human proteins. The levels of IgE autoantibodies correspond with disease severity. Several mechanisms of IgE autoimmunity may contribute to the pathogenesis of atopic dermatitis.
Nouveaux noyaux pour l’échantillonnage de signaux impulsionnels à bande non-limitée (2015)

National audience
A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display (2009)

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment available for patients with B-cell chronic lymphocytic leukemia (B-CLL). Here, we show that post-alloHSCT antibody repertoires can be mined for the discovery of fully human monoclonal antibodies to B-CLL cell-surface antigens. Sera collected from B-CLL patients at defined times after alloHSCT showed selective binding to primary B-CLL cells. Pre-alloHSCT sera, donor sera, and control sera were negative. To identify post-alloHSCT serum antibodies and subsequently B-CLL cell-surface antigens they recognize, we generated a human antibody-binding fragment (Fab) library from post-alloHSCT peripheral blood mononuclear cells and selected it on primary B-CLL cells by phage display. A panel of Fab with B-CLL cell-surface reactivity was strongly enriched. Selection was dominated by highly homologous Fab predicted to bind the same antigen. One Fab was converted to immunoglobulin G1 and analyzed for reactivity with peripheral blood mononuclear cells from B-CLL patients and healthy volunteers. Cell-surface antigen expression was restricted to primary B cells and up-regulated in primary B-CLL cells. Mining post-alloHSCT antibody repertoires offers a novel route to discover fully human monoclonal antibodies and identify antigens of potential therapeutic relevance to B-CLL and possibly other cancers. Trials described herein were registered at www.clinicaltrials.gov as nos. NCT00055744 and NCT00003838.
Spatially Resolved Analysis of Material Response to Destructive Environments Utilizing Three-Dimensional Scans (2018)

Abstract not provided.
Molecular detection of Coxiella burnetii in heart valve tissue from patients with culture-negative infective endocarditis (2018)

Coxiella burnetii is a common cause of blood culture-negative infective endocarditis (IE). Molecular detection of C burnetii DNA in clinical specimens is a promising method of diagnosing Q fever endocarditis. Here, we examined the diagnostic utility of Q fever polymerase chain reaction (PCR) of formalin-fixed heart valve tissue from patients with blood culture-negative IE who underwent heart valve surgery. Clinical and laboratory data of patients with blood culture-negative IE who underwent heart valve surgery during a 6-year period and for whom biopsy tissues were available were reviewed retrospectively. Blood culture-positive IE patients who underwent heart valve surgery within the last 3 years were used as controls. Heart valve samples were cultured and also subjected to histological examination and PCR for Q fever, brucellosis, and bartonellosis. Data from 20 patients with blood culture-negative IE and 20 with blood culture-positive IE were analyzed. Eight cases of blood culture-negative IE were PCR-positive for C burnetii (40%; 95% confidence interval, 19-64). No specimen was PCR-positive for brucellosis or bartonellosis. Histologically, 4 of 8 specimens with a positive Q fever PCR result were characterized by clusters of multinucleated giant cells without a fibrin ring. None of 20 patients with blood culture-negative IE received anti-Coxiella antibiotic therapy due to lack of clinical suspicion. Six-month mortality was higher in the Q fever PCR-positive group than in the Q fever PCR-negative group [38% (3/8) vs 0% (0/12), P = .049). Of the 20 patients with blood culture-positive IE, none yielded a positive Q fever PCR result for valve tissue. Approximately 40% of patients with culture-negative IE who received heart valve surgery were PCR-positive for Q fever; patients without clinical suspicion suffered high mortality. These data suggest that Q fever IE in patients with culture-negative IE is often missed in routine clinical practice.
Secondary metabolism in Penicillium expansum: Emphasis on recent advances in patulin research (2017)

The plant pathogenic fungus Penicillium expansum is a major concern of the global food industry due to its wide occurrence and ability to produce various mycotoxins, of which the most significant is patulin. Relatively less highlighted in the literature, in comparison with the other food-borne mycotoxins, patulin is one of the main factors in economic losses of vegetables and fruits. Otherwise, patulin is a health hazard which results in both short-term and long-term risks. This review includes knowledge on the biosynthetic mechanisms used for secondary metabolite production in P. expansum, with special emphasis on patulin biosynthesis. The abiotic factors triggering the production of patulin and the strategies developed to reduce or prevent the contamination by this mycotoxin are comprehensively discussed. The database presented in this review would be useful for the prioritization and development of future research.
ChemInform Abstract: Production of Synthesis Gas. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Data-Analytics Tutorial: Building Predictive Models for Oil Production in an Unconventional Shale Reservoir (2018)

Summary Considerable amounts of data are being generated during the development and operation of unconventional reservoirs. Statistical methods that can provide data-driven insights into production performance are gaining in popularity. Unfortunately, the application of advanced statistical algorithms remains somewhat of a mystery to petroleum engineers and geoscientists. The objective of this paper is to provide some clarity to this issue, focusing on how to build robust predictive models and how to develop decision rules that help identify factors separating good wells from poor performers. The data for this study come from wells completed in the Wolfcamp Shale Formation in the Permian Basin. Data categories used in the study included well location and assorted metrics capturing various aspects of well architecture, well completion, stimulation, and production. Predictive models for the production metric of interest are built using simple regression and other advanced methods such as random forests (RFs), support-vector regression (SVR), gradient-boosting machine (GBM), and multidimensional Kriging. The data-fitting process involves splitting the data into a training set and a test set, building a regression model on the training set and validating it with the test set. Repeated application of a “cross-validation” procedure yields valuable information regarding the robustness of each regression-modeling approach. Furthermore, decision rules that can identify extreme behavior in production wells (i.e., top x% of the wells vs. bottom x%, as ranked by the production metric) are generated using the classification and regression-tree algorithm. The resulting decision tree (DT) provides useful insights regarding what variables (or combinations of variables) can drive production performance into such extreme categories. The main contributions of this paper are to provide guidelines on how to build robust predictive models, and to demonstrate the utility of DTs for identifying factors responsible for good vs. poor wells.