gebhart/patrepeval huggingface dataset:
Template Catalysis:  Catalytic Metalation of Porphyrins by Apocytochrome b562 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTemplate Catalysis: Catalytic Metalation of Porphyrins by Apocytochrome b562Yasuhiro Ishida, Katsuaki Konishi, Teruyuki Nagamune, and Takuzo AidaView Author Information Department of Chemistry and Biotechnology Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 34, 7947–7948Publication Date (Web):August 10, 1999Publication History Received17 March 1999Published online10 August 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ja990868thttps://doi.org/10.1021/ja990868trapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views316Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Bioinorganic chemistry,Genetics,Metalation,Peptides and proteins,Pyrroles Get e-Alerts
Tumor Necrosis Factor Receptor Deficiency Alters Matrix Metalloproteinase 13/Tissue Inhibitor of Metalloproteinase 1 Expression in Murine Silicosis (2001)

Murine exposure to silica is associated with enhanced tumor necrosis factor alpha (TNF-alpha) expression and matrix deposition. The regulation of TNF is mediated through TNF receptor (TNFR) activation of transcription factors. In the present work we have studied the importance of the individual TNFR in silica-induced lung inflammation and matrix deposition in mice. We studied RNA expression of TNF, alpha1(I) collagen, interstitial collagenase (MMP-13), and its inhibitor (TIMP-1) in the lungs of silica-treated mice. Furthermore, we correlated MMP-13/TIMP-1 RNA abundance with activation of the transcription factors AP-1 and NF-kappaB in the lungs of C57BL/6 mice, and of mice deficient in one of the two types of TNFR (p55(-/-) or p75(-/-)), exposed to silica (0.2 g/kg) or saline by intratracheal instillation. Animals were killed 28 d after exposure and lung hydroxyproline (HP), TNF, alpha1(I) collagen, MMP-13, and TIMP-1 RNA abundance was measured. AP-1 and NF-kappaB activation was studied by gel-shift assays. Compared with C57BL/6 mice, p55(-/-) and p75(-/-) mice significantly (*p < 0.05) decreased lung HP accumulation in response to silica. All murine strains enhanced TNF and alpha1(I) collagen mRNA in response to silica. Enhanced (p < 0.05) MMP-13 RNA expression was also observed in all murine strains in response to silica. Enhanced (p < 0.05) TIMP-1 RNA expression was observed in C57BL/6 mice, but not in p55(-/-) or p75(-/-) mice, in response to silica. NF-kappaB activation was observed in all murine strains, whereas AP-1 activation was observed only in C57BL/6 mice after silica treatment. These data suggest that TNFR deletion modifies MMP-13/ TIMP-1 expression in favor of matrix degradation.
Effects of Precursor Concentration on Dimensional Size, Defect State, and Gas Sensing Performance of MoS2 Sheets Synthesized by Hydrothermal Method (2018)

The objective of this study is to investigate effects of precursor concentration on dimensional size, defect state, and gas sensing performance of MoS 2 sheets synthesized by hydrothermal method with various precursor concentrations (0.14–1.4 m ) in fixed HCl solution (7 m ). The MoS 2 sheets show a defect‐rich and strained structure. When precursor concentration is increased, dimensional size of the sheet is increased while the specific surface area of the sheet is decreased. The MoS 2 sensor made with 0.14 m precursor solution exhibits superior sensing performance with high sensitivity (372%) and rapid recovery time (&lt;16 min) at room temperature in a 500 ppm NO 2 gas atmosphere due to enhanced active site resulting from the highest specific surface area. In addition, all MoS 2 samples show a complete recovery after response to NO 2 gas probably related to the defective and strained surface resulting from the use of HCl surfactant.
Stochastic Spectrum Pool Reassignment for Cognitive Relay Systems (2008)

We consider a cognitive wireless relay system that operates on secondary spectrum sharing basis using spectrum pooling. A spectrum pool comprises of a set of available narrowband subchannels over which secondary users may communicate without causing harmful interference to primary users. In the proposed relay system, a source node transmits data symbols on an available spectrum pool to the relay node. At the relay, the received data symbols are amplified, permuted and forwarded to the destination node on an available spectrum pool. The problem of spectrum pool reassignment constitutes the determination of the permutation mapping at the relay node. Our goal is to maximize the ergodic capacity of the relay system, given knowledge of the average signal to noise ratios pertaining to the subchannels in the spectrum pools, by determining the optimum spectrum pool reassignment.
An H.264/AVC High422 Profile and MPEG-2 422 Profile Encoder LSI for HDTV Broadcasting Infrastructures (2009)

An H.264/AVC encoder LSI (named SARA/E) that supports High422 profile, as well as 422 profile of MPEG-2, has been developed for HDTV broadcasting infrastructures. It contains 257GOPS motion estimation and compensation (ME/MC) engines with search ranges of -271.75 to +199.75 (H) /-109.75 to +145.75 (V), which can utilize almost all H.264/AVC ME/MC tools, multiple reference frame, variable block size, 1/4-pel prediction, macroblock adaptive field/frame prediction, temporal/spatial direct mode, and weighted prediction. Our evaluations show that it can encode fast moving scenes with 1.2 to 1.7 dB higher than the JM. It was successfully fabricated in a 90 nm 9level metal CMOS technology. It integrates 140 million transistors.
A Polymorphism in the Gene for IGF-I (2001)

Evidence is accumulating that low levels of IGF-I play a role in the pathogenesis of type 2 diabetes and cardiovascular diseases. We examined the role of a genetic polymorphism in the promoter region of the IGF-I gene in relation to circulating IGF-I levels and growth measured as body height, and we studied the relationship of this polymorphism with type 2 diabetes and myocardial infarction. The relation between the IGF-I polymorphism and body height was assessed in a population-based sample of 900 subjects from the Rotterdam Study. Within each genotype stratum, 50 subjects were randomly selected for a study of the relation of this polymorphism with serum IGF-I levels. To assess the risk for type 2 diabetes, we studied 220 patients and 596 normoglycemic control subjects. For myocardial infarction, 477 patients with evidence of myocardial infarction on electrocardiogram and 808 control subjects were studied. A 192-bp allele was present in 88% of the population, suggesting that this is the wild-type allele from which all other alleles originated. Body height was, on average, 2.7 cm lower (95% CI for difference -4.6 to -0.8 cm, P = 0.004), and serum IGF-I concentrations were 18% lower (95% CI for difference -6.0 to -1.3 mmol/l, P = 0.003) in subjects who did not carry the 192-bp allele. In noncarriers of the 192-bp allele, an increased relative risk for type 2 diabetes (1.7 [95% CI 1.1-2.7]) and for myocardial infarction (1.7 [95% CI 1.1-2.5]) was found. In patients with type 2 diabetes, the relative risk for myocardial infarction in subjects without the 192-bp allele was 3.4 (95% CI 1.1-11.3). Our study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction.
A close-up thermodynamic analysis of a hypothetical sorption heat transformers assembly used to feed an ORC cycle from a low exergy heat source: Part I (2022)

The present study looks at the feasibility of a small scale power plant configuration with nominal electric output of 100 kWe fed from low potential thermal heat source, especially from flat thermal solar collectors operating in the range of 343to 373K. The power plant uses multiple cascaded sorption heat transformers (AbHT and AdHT) coupled with an Organic Rankine Cycle (ORC). The study revealed for the proposed system, that it would be possible to generate electrical power over the entire range of the proposed temperature within the considered hypotheses. The work was split in two parts. The first part presents a complete state of the art of the thermal cascade assembly of the upgrade of low-potential heat energy technology and small-power generation system. Moreover, the power plant configuration with cascaded sorption heat transformers and small-power generation device is described, followed by the presentation of the developed mathematical model with all equations and fundamental laws specific to each compartment of the proposed power plant. The main results, discussions and conclusions are presented separately in a second part of this work.
Human Regional Cerebral Blood Flow during Rapid-Eye-Movement Sleep (1991)

Owing to the coupling between CBF and neuronal activity, regional CBF is a reflection of neural activity in different brain regions. In this study we measured regional CBF during polysomnographically well-defined rapid-eye-movement (REM) sleep by the use of single photon emission computerized tomography and the new tracer 99mTc-dl-hexamethylpropyleneamine. Eleven healthy volunteers aged between 22 and 27 years were studied. CBF was measured on separate nights during REM sleep and during EEG-verified wakefulness. On awakening from REM sleep, all subjects reported visual dreams. During REM sleep CBF increased by 4% (p less than 0.01) in the associative visual area, while it decreased by 9% (p less than 0.01) in the inferior frontal cortex. The CBF increase in the associative visual area suggests that activation of cerebral structures processing complex visual material is correlated to visual dream experiences. On the other hand, the reduced involvement of the inferior frontal cortex observed during REM sleep might explain the poor temporal organization and bizarreness often experienced in dreams.
Growing up gay and religious. Conflict, dialogue, and religious identity strategies (2010)

Homosexuality has become a divisive issue in many religious communities. Partly because of that, individuals growing up in such a community and experiencing same sex attractions need to negotiate the messages about homosexuality with their own experiences. This paper explores the identity strategies of religious communities as the background of individual identity struggles. Following a discussion of Bauman's grammars of identity/alterity, it describes four different discourses employed in conservative protestant and evangelical circles: holiness, subjectivity, obedience, and responsibility and four modes of negotiation: Christian lifestyle, gay lifestyle, commuting (compartmentalisation), and integration. By combining an analysis of discourses on the community level with individual strategies, this narrative research helps to better understand the interactions of (group) culture and individual coping.
A Statistical Approach To An Expert Diagnostic Ultrasonic System (1986)

The techniques of statistical pattern recognition are implemented to determine the best combination of tissue characterization parameters for maximizing the diagnostic accuracy of a given task. In this paper, we considered combinations of four ultrasonic tissue parameters to discriminate between normal liver and chronic hepatitis. The separation between normal and diseased samples was made by application of the Bayes test for minimum risk which minimizes the error rate for classifying tissue states while including the prior probability for the presence of disease and the cost of misclassification. Large differences in classification performance of various tissue parameter combinations were demonstrated by ROC analysis. The power of additional features to classify tissue states, even those derived from other imaging modalities, can be compared directly in this manner.
Modeling of initial bubble growth rates during high-intensity focused ultrasound (2005)

In therapeutic applications of biomedical ultrasound, it is important to understand the behavior of cavitation bubbles. For applications that use high-intensity focused ultrasound (HIFU), both large negative acoustic pressures and heating can independently lead to bubble formation. Although neglected previously, heating during HIFU is expected to affect the growth and dissolution of bubbles by both raising the vapor pressure and promoting outgassing from gas-saturated tissues. Herein, the dynamics of a single, spherical bubble in water have been modeled using the Gilmore equation closed with an energy balance on bubble contents for calculation of pressures inside the bubble. Moreover, heat and mass transfer at the bubble wall are incorporated using the Eller-Flynn zeroth-order approximation for gas diffusion, an estimation of non-equilibrium phase change based on the kinetic theory of gases, and assumed shapes for the spatial temperature distribution in the surrounding liquid [Yasui, J. Phys. Soc. Jpn. 65, 2830–2840 (1996)]. This model allows explicit coupling of the ambient heating during HIFU to the thermodynamic state of an oscillating bubble and is currently being used to explore the growth rates of initially small, undetectable bubbles exposed to various HIFU treatment protocols. [Work supported by NIH T32-EB-001650, NIH DK43881, and NSBRI SMS00203.]
[Immunostimulating activity of vaccines in the treatment of recurrent urinary tract infections. I]. (1999)

The authors inform about the immunomodulatory properties of the vaccine URVAKOL aimed for the treatment of recidiving urinary infections. The results of immunostimulatory activity of the preparation and its effects on cellular and humoral immunity in mice following intraperitoneal administration of the vaccine are presented. The vaccine markedly increases cytotoxic activity of adhering peritoneal cells and has protective effects in model infection induced by intracellular pathogen Francisella tularensis (strain 15 L). (Tab. 6, Fig. 6, Ref. 9.)
Cell-mediated lympholytic responses against autologous cells modified with haptenic sulfhydryl reagents. I. Effector cells can recognize two distinct classes of hapten-reactive self sites on cell surface proteins. (1981)

Mouse spleen cells were modified with a sulfhydryl-reactive reagent, N-iodoacetyl-N'-(5-sulfonic-1-naphthyl) ethylene diamine (I-AED) and used as stimulator cells in primary in vitro cultures with unmodified spleen cells of the same strain. CTL could be readily demonstrated when tested on hapten-modified syngeneic target cells. These CML responses were hapten specific and H-2 restricted. In the H-2b strain, effector cell populations were identified that recognized AED in association with K-end and D-end coded self MHC products. Functional modification of the target cells by I-AED can be effectively blocked by prereacting the cells with other SH-reagents, which is consistent with CTL recognition of the hapten on cysteine residues. Since these premodifications of the cell surface do not block the functional modification by trinitrobenzene sulfonate (TNBS), the sulfhydryl-reactive compounds and TNBS modify distinct classes of cell surface groups as determined by CTL function. The results of antibody inhibition experiments are also consistent with this interpretation. Using fluorescent labeled anti-hapten antibodies, FACS II analysis showed that there are approximately 20-fold fewer AED than TNP groups on the approximately 20-fold fewer AED than TNP groups on the cell surface when equivalent concentrations of I-AED and TNBS are compared. The possibility is discussed that these sulfhydryl-reactive compounds can be used together with the H-2Kb mutants for the localization of H-2 coded self determinants recognized in association with foreign antigens.
Performance-Portable Autotuning of OpenCL Kernels for Convolutional Layers of Deep Neural Networks (2016)

We present a portable and highly-optimized Deep Neural Network (DNN) algorithm and its implementation techniques. Our approach is a novel combination of existing HPC techniques that methodically applies autotuning as well as data layout and low-level optimizations that achieve performance matching and/or exceeding what is possible with either reverse engineering and manual assembly coding or proprietary vendor libraries. The former was done inside the maxDNN implementation and the latter is represented by cuDNN. Our work may be directly applied to the most time consuming part of DNN workflow, namely the training process which often needs a restart when it stagnates due to, for example, diminishing gradients and getting stuck in local minima. With the result of performance tests on a consumer-grade GPU with the latest High Bandwidth Memory (HBM) stack, our methodology can match a server grade hardware at a fraction of the price. Another tuning sweep on a new GPU architecture from a different vendor also attests to the portability of our approach and the quality of our implementation.
Defect Identification in Large Area Electronic Backplanes (2009)

We describe a rapid testing system for active matrix thin-film transistor (TFT) backplanes which enables the identification of many common processing defects. The technique spatially maps the charge feedthrough from TFTs in the pixel and is suited for pixels with switched-capacitor architecture.
Gas Bubble Motion Artifact in MDCT (2008)

Gas bubble motion during CT generates a semicircular air-attenuation artifact that has not been previously described to our knowledge. The artifact is typically found in bowel and other liquid-containing structures in which a bubble of gas floats up through a liquid medium during CT.
RAND Review: Vol. 26, No. 2, Summer 2002 (2002)

Since Sept. 11, 2001, RAND researchers have examined the dimensions of the terrorist threat, and the potential responses to it, in greater detail than ever before in RAND’s three decades of counterterrorism research. Other stories in this issue of RAND Review discuss why some societies die while others survive, why some drugs are regulated while others are not, and why the best kind of child care often comes from an unexpected source.
Capillary Torque Caused by a Liquid Droplet Sandwiched between Two Plates (2009)

Capillary force makes a liquid droplet's surface have the minimum area. If the droplet is sandwiched between two plates, it exerts capillary force on the plates. The magnitude of the force depends on the shape of the sandwiched droplet, which is in turn determined by the shape of the plates and the volume of the liquid. The liquid's shape, however, is hard to determine analytically. In this paper, the torque caused by a droplet sandwiched between two noncircular plates is experimentally and theoretically analyzed. We patterned a magnetic material on the surface of the plates and used it to apply a magnetic force to the plates. The torque on the plates was measured. The torque caused by capillary force was calculated by observing the equilibrium between the capillary force and magnetic force. We obtained approximate theoretical solutions for the liquid's shape and torque and verified that they were in accordance with the experimental results. The experimental and theoretical results presented in this paper are useful for designing microdevices or self-assemblies actuated by capillary force.
High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells. (1994)

In human leukemic cells clinically relevant concentrations of taxol have been demonstrated to induce the biochemical and morphologic hallmarks of apoptosis (Leukemia 1993;7:563-568). Since overexpression of the bcl-2 gene has been reported to retard apoptosis due to a variety of anticancer agents, we examined and compared taxol-induced intracellular microtubular bundling and apoptosis in pre-B human leukemia 697 cells and their counterparts which have been transfected with and overexpress cDNA derived from the bcl-2 gene. Treatment with 0.1 or 1.0 mumol/l taxol for 24 h resulted in internucleosomal DNA fragmentation and morphologic features of apoptosis in 697 cells, but not in 697/BCL-2 cells. However, indirect immunofluorescent staining with anti-tubulin antibody revealed that taxol treatment produces stable microtubule bundles resistant to calcium-mediated disassembly in 697, as well as 697/BCL-2 cells. In addition, taxol-induced microtubule bundling was associated with a marked accumulation of the two cell types in the G2/M phase of the cell cycle. Following exposure to taxol, when 697 cells were washed and kept in drug-free medium, they showed rapid onset of apoptosis followed by loss of cell viability and a decline in cell numbers. In contrast, identically treated 697/BCL-2 cells kept in drug-free medium remained in a growth arrested state, but showed little evidence of apoptosis for up to 4 days. They eventually demonstrated features of apoptotic cell death and loss of viability between 5 and 7 days. This was not accompanied by a decrease in p26BCL-2 levels. Anti-phosphotyrosine or anti-MAP kinase immunoblot analyses of proteins isolated from taxol-treated 697 and 697/BCL-2 cells failed to show any difference in tyrosine phosphorylation of cellular proteins. Therefore, our findings indicate that in 697/BCL-2 cells, high levels of p26BCL-2 significantly delay taxol-induced endonucleolytic internucleosomal DNA fragmentation and apoptosis, but do not affect taxol-induced microtubule bundling or cell cycle growth arrest. The delayed onset of taxol-induced DNA fragmentation and apoptosis in 697/BCL-2 cells without down-regulation of p26BCL-2 levels suggests that an alternative mechanism of taxol-mediated apoptosis might be triggered which is unimpeded by high p26BCL-2 levels, or taxol-induced prolongation of mitotic arrest may lead to the inactivation or inhibition of that mechanism by which p26BCL-2 is able to block apoptosis.
Prognostic Factors for Urachal Cancer: A Bayesian Model-Averaging Approach (2014)

The Mayo staging system might be more effective than the Sheldon staging system. In addition, the multivariate analyses suggested that tumor size may be a prognostic factor for urachal carcinoma.