gebhart/patrepeval huggingface dataset:
Radiochemical and analytical aspects of inter-institutional quality control measurements on radiopharmaceuticals (2019)

Measurement of RCP shows a strong method- and system-dependency, even when parameters are validated, standardized and SOP are followed. Release criteria are frequently based on RCP data from one central location. The lack of inter inter institutional validation and standardization in RCP determination makes the results therefore rather arbitrary. For multicenter trials, we recommend to compare locally determined RCP under validated and standardized conditions of in-line activity detection between institutes for each radiopharmaceutical.
2A2-J04 Development and Control of Pneumatic Robot Arm for Industrial Fields(Mechanism and Control for Actuator) (2011)

In this research, we have developed the pneumatic robot arm driven by pneumatic actuators as the versatile end effector of a material handling system. The arm consists of the hand and wrist parts. The hand can grasp various objects without force sensors and feedback control. Therefore, we aim to control the wrist motions to expand the hand motion space. We construct the experimental models of the drive system of the pneumatic robot wrist. We design the control systems using simulations with the constructed models. After that, we try to control the wrist motions with constructed controllers. As a result, we can control the wrist motions with constructed PI controllers. The wrist models are coincident with the motions of the wrist accurately. Therefore, we can get the experimental results that meet the simulation conditions.
Induction of the Carrier State in Pigeons Infected with Salmonella enterica Subspecies enterica Serovar Typhimurium PT99 by Treatment with Florfenicol: a Matter of Pharmacokinetics (2008)

Paratyphoid caused by Salmonella enterica subsp. enterica serovar Typhimurium is the main bacterial disease in pigeons. The ability of Salmonella serovar Typhimurium to persist intracellularly inside pigeon macrophages results in the development of chronic carriers, which maintain the infection in the flock. In this study, the effect of drinking-water medication with florfenicol on Salmonella infection in pigeons was examined. The pharmacokinetics of florfenicol in pigeons revealed a relatively high volume of distribution of 2.02 liters/kg of body weight and maximum concentrations in plasma higher than the MICs for the Salmonella strain used (4 microg/ml) but quick clearance of florfenicol due to a short half-life of 1.73 h. Together with highly variable bioavailability and erratic drinking-water uptake, these parameters resulted in the inability to reach a steady-state concentration through the continuous administration of florfenicol in the drinking water. Florfenicol was capable of reducing only moderately the number of intracellular salmonellae in infected pigeon macrophages in vitro. Only at high extracellular concentrations (>16 microg/ml) was a more-than-10-fold reduction of the number of intracellular bacteria noticed. Florfenicol treatment of pigeons via the drinking water from 2 days after experimental inoculation with Salmonella serovar Typhimurium until euthanasia at 16 days postinoculation resulted in a reduction of Salmonella shedding and an improvement in the fecal consistency. However, internal organs in florfenicol-treated pigeons were significantly more heavily colonized than those in untreated pigeons. In conclusion, the oral application of florfenicol for the treatment of pigeon paratyphoid contributes to the development of carrier animals through sub-MIC concentrations in plasma that do not inhibit intracellular persistency.
Supramolecular Host—Guest Systems in Zeolites Prepared by Ship‐in‐a‐Bottle Synthesis (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A portable cosmic ray detector and display (2003)

We have developed a hand-held, particle tracking detector based on scintillating-glass, fiber-optic plate technology for applications in classroom teaching. The active element is sensitive to ionizing radiation and is a coherent fiber-optic plate consisting of 10/sup 6/ individual clad fiber waveguides that contain Terbium (3+) oxide in a silicate glass host. Scintillation light in the individual fiber elements is transferred via total internal reflection to a multi-stage image intensifier that senses and amplifies the light signal while maintaining the spatial coherence of the input optical image. The output screen of the image intensifier can be viewed directly by eye under low-level room light conditions or via video imaging with a CCD camera. The system is ideal for hands-on laboratory use and for public lecture demonstrations.
Penile allotransplantation: early outcomes from reported cases and survivorship considerations (2021)

Vascular composite allografts are at the forefront of medical and surgical innovation. With this new technique and the ability to transplant a face, hands, an abdominal wall, a uterus, or even a penis, patients can undergo operations that may drastically improve their quality of life. Although this process presents significant opportunities it is not always an easy road and requires significant upfront counseling and life-long immunosuppression. Often the recovery course is long, with functionality taking months to years to gain. Immunosuppression must be used to prevent rejection of the allograft although it has serious long-term side-effects. Only five patients have undergone penile allotransplantation but reported outcomes from these small numbers have nonetheless offered significant lessons with each patient. While the operation is still in its infancy, it is certain that shared experiences by surgical teams will yield improved outcomes in the future.
Highly reliable and efficient semiconductor wafer-bondedAlGaInP/GaP light-emitting diodes (1996)

Semiconductor wafer bonding is employed to fabricate very high efficiency transparent-substrate (TS) AlGaInP light-emitting diodes (LEDs) with projected lifetimes in excess of 100000 h under accelerated life test at an ambient temperature of 55°C (70 A/cm2). Furthermore, we demonstrate wafer-bonded TS AlGaInP red LEDs with external quantum efficiencies of 23.7% at 635.6 nm (20 mA, DC, 250°C).
Search for type-III seesaw heavy leptons in dilepton final states in pp collisions at $$ \sqrt{s} = 13\,{\text {TeV}} $$ with the ATLAS detector (2021)

Abstract A search for the pair production of heavy leptons as predicted by the type-III seesaw mechanism is presented. The search uses proton–proton collision data at a centre-of-mass energy of 13 TeV, corresponding to $$ 139\,{\text {fb}}^{-1} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>139</mml:mn> <mml:mspace/> <mml:msup> <mml:mrow> <mml:mtext>fb</mml:mtext> </mml:mrow> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> of integrated luminosity recorded by the ATLAS detector during Run 2 of the Large Hadron Collider. The analysis focuses on the final state with two light leptons (electrons or muons) of different flavour and charge combinations, with at least two jets and large missing transverse momentum. No significant excess over the Standard Model expectation is observed. The results are translated into exclusion limits on heavy-lepton masses, and the observed lower limit on the mass of the type-III seesaw heavy leptons is 790 GeV at 95% confidence level.
Probing guided modes in a monolayer colloidal crystal on a flat metal film (2012)

Two-dimensional slab hybrid metal-dielectric photonic crystals, which are prepared by assembling polymer colloidal spheres into closely packed monolayers of hexagonal symmetry on a gold-coated glass substrate, show an improved confinement of light compared with a colloidal monolayer on a glass substrate. We demonstrated that the optical response of such hybrid crystals consists of diffractively coupled waveguiding modes, Fabry--Perot resonances, and Mie resonances. Correspondingly, two major mechanisms, namely, band transport and hopping of localized excitations, participate in the in-plane light transport in such hybrid crystals.
Regenerative medicine based on muscle stem cells. (2009)

and -4) as well as the angiogenic and anti-angiogenic factors (VEGF and sFLT-1). Interestingly, it has been observed that female MDSCs (F-MDSCs) can more efficiently regenerate the dystrophic skeletal muscle of mdx mice (a mouse model of Duchenne muscular dystrophy) than their male MDSCs (M-MDSCs) counterparts. Moreover, M-MDSCs when compared to F-MDSCs have been shown to be superior at bone and cartilage repair. MDSCs are influenced by environmental cues released within dystrophic or injured skeletal muscle, which have been shown to negatively impact MDSCs and cause the cells to differentiate toward a fibrotic cell lineage and hence produce scar tissue rather than healthy skeletal muscle fibers. Potential strategies are being explored to prevent the formation of scar tissue within injured skeletal muscle by blocking the action of TGF-‚1. Finally, blood vessels contain several cell types, including myo-endothelial cells and pericytes, and are likely the place of origin of the murine MDSCs discussed above. The results outlined above open new avenues by which researchers could use muscle stem cellbased gene therapy and tissue engineering to improve tissue regeneration. J Musculoskelet Neuronal Interact 2008; 8(4):337
Role of the Malate-Aspartate Shuttle in Renal Sodium Transport in the Rat (1981)

1. Experiments were designed to establish the relationship between renal gluconeogenesis and sodium transport. Six inhibitors of gluconeogenesis, with different sites of action, were tested in the isolated perfused rat kidney in which renal function, and in particular Na+ reabsorption, was followed. 2. In kidneys from fed or starved rats specific inhibitors of gluconeogenesis neither inhibited nor stimulated Na+ reabsorption; gluconeogenesis and sodium reabsorption are therefore independent of one another under these conditions. 3. Inhibitors of transaminase or malic dehydrogenase inhibited gluconeogenesis from lactate and pyruvate respectively; the transaminase inhibitor significantly inhibited oxidation of lactate and glucose. 4. Sodium reabsorption was inhibited by a transaminase inhibitor when glucose or lactate was the sole substrate, and by inhibition of malic dehydrogenase when pyruvate was the substrate. 5. These results indicate that the malate--aspartate shuttle controls Na+ reabsorption in the intact kidney by regulating substrate oxidation (and the provision of energy) rather than by any direct involvement of gluconeogenesis in Na+ transport.
Structural and Radio Frequency Co-Design and Optimization of Large Deployable Reflectarrays for Space Missions (2023)

The structural and radio frequency (RF) design and optimization of a large deployable faceted reflectarray (RA) generating double polarization contour beam are presented in this work. The issue addressed is the thermoelastic stability of large RAs and the impact of the thermoelastic deformation (TED) under transverse thermal gradient on the RA performances. Finite element TED analysis is conducted on a deployable RA with self-standing structures, demonstrating the detrimental effects of the in-orbit TED impact on the RA performances, estimated to be above 3 dB losses. To this extent, a novel structural solution is proposed, based on the use of reliable mechanical support capable to mitigate the TED. The mechanical design reorientation is contingent on the RF design reformulation. The proposed novel mechanical and RF co-design concept and methodology allows the conception of a low-profile, thermo-structurally stable RA with compliant radiation patterns and high cross-polarization discrimination in the worst case thermal load. This methodology is based on a direct optimization of nine-panel faceted RA composed of advanced high-order Phoenix cells directly optimized to fulfill the contoured beam requirements and by respecting the local periodicity requirements of the layout.
Optical waveguiding in suspensions of dielectric particles (2005)

Waveguiding is observed in a liquid core/liquid cladding waveguide containing a suspension of dielectric particles in the core. The threshold for guiding is determined by the numerical aperture of the effective refractive index.
Supplementary Materials and Methods, Supplementary Tables 1 through 3, and Supplementary Figure 1 from The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models (2023)

&lt;p&gt;Supplementary materials and methods. Suppl Table 1. MMS combination PF50 cell line assays. Concentration-dependent potentiation of MMS (PF50 ratios). Suppl Table 2. Permeability of AZD2461 and olaparib were assessed. Suppl Table 3. Activity of olaparib and AZD2461 alone or in combination with the P-gp inhibitor verapamil in the colorectal cancer cell line HCT-15, which expresses high levels of P-gp. Suppl Fig. 1. Immunofluorescence for poly(ADP-ribose) in human A549 cells. Suppl Fig. 2. Analysis of both in vivo pharmacokinetics (PK) and pharmacodynamics (PD) in tumors taken from SW620 (human colon carcinoma) xenograft-bearing mice. Suppl Fig. 3. Colony formation (clonogenic) assays in the intrinsically high P-gp-expressing MRE11-deficient HCT-15 human colorectal cell line. Suppl. Fig. 4. Combination efficacy studies. Suppl Fig. 5. Relative body weight changes in mice following treatment with 10 mg/kg AZD2461 and olaparib in combination with temozolomide. Suppl. Fig. 6. A serial dilution of RNA concentration was used to establish a standard curve for determining the reaction efficiency of PARP1, PARP2, PARP3, and housekeeper gene (PPIA: cyclophilin A) TaqMan RT-PCR assays in both rat and mouse species; Determination of optimal reference gene for rat-mouse data normalization. Suppl Fig. 7.A. A serial dilution of reference RNA (Qiagen) concentration was used to establish a standard curve for determining the reaction efficiency of PARP3 and housekeeper genes (PPIA: cyclophilin and YWHAZ: tyrosine 3-monooxygenase/tryptohpan 5-monooxygenase activation protein, zeta polypeptide) SybrGreen RT-PCR assays in both rat and human species; Determination of optimal reference gene for rat-human data normalization. Suppl Fig. 8. Relative body weight changes in rat following treatment with 10 mg/kg AZD2461 and olaparib in combination with temozolomide; Relative body weight changes in rat following treatment with 20 mg/kg AZD2461 and olaparib in combination with temozolomide.&lt;/p&gt;
Combining Morphological and Metabarcoding Approaches Reveals the Freshwater Eukaryotic Phytoplankton Community (2020)

Background: Phytoplankton diversity can be difficult to ascertain from morphological analyses, because of the existence of cryptic species and pico-and concealed phytoplankton. Indepth sequencing and metabarcoding can reveal microbial diversity, and identify novel diversity. However, there has been little comparison of metabarcoding and morphological datasets derived from the same samples, and metabarcoding studies covering total eukaryotic phytoplankton diversity are rare. In this study, the variable V7 region of the 18S rDNA gene was employed to explore eukaryotic phytoplankton diversity in 11 Chinese freshwater environments, and further compared with the dataset obtained through morphological identification. www.videleaf.com Results: Annotation by the evolutionary placement algorithm (EPA) rather than alignment with the SILVA database improved the taxonomic resolution, with 346 of 524 phytoplankton operational taxonomic units (OTUs) being assigned to the genus or species level. The number of unassigned OTUs was greatly reduced from 259 to 178 OTUs by using the EPA in place of the SILVA database. Metabarcoding detected 3.5 times more OTUs than the number of morphospecies revealed by morphological identification; furthermore, the number of species and the Shannon-Wiener index inferred from the two methods were correlated. A total of 34 genera were identified via both methods, while 31 and 123 genera were detected solely in the morphological or metabarcoding dataset, respectively.
Lateral ion transport in nematic liquid-crystal devices (2003)

Liquid crystals used in electronic displays usually contain small amounts of ions that move under the influence of the varying applied electric field. It is well known that the motion of ions perpendicular to the substrates may lead to modified electric fields resulting in image sticking effects. During operation, the modulation in the director tilt angle can also lead to a net residual lateral component of the ion motion, parallel with the glass plates. A sustained ac driving voltage will accumulate the lateral ion motion and may result in image sticking effects near the pixel edge. Such effects have indeed been observed in supertwisted nematic cells.
Direct and oxidative dehydrogenation of propane: from catalyst design to industrial application (2021)

This critical review evaluates the state-of-the-art in propane dehydrogenation catalysis using oxidative and non-oxidative methods, with an emphasis on the sustainability and suitability for process commercialisation.
Supplementary Methods, Figure Legends 1-3 from Molecular Target Characterization and Antimyeloma Activity of the Novel, Insulin-like Growth Factor 1 Receptor Inhibitor, GTx-134 (2023)

Supplementary Methods, Figure Legends 1-3 from Molecular Target Characterization and Antimyeloma Activity of the Novel, Insulin-like Growth Factor 1 Receptor Inhibitor, GTx-134
DC-bus voltage regulation for DC distribution system with controllable DC load (2017)

This paper shows a dc-bus voltage regulation for a dc distribution system integrated with a single-phase bidirectional inverter through using a control method to operate with no grid information, and without contributing the solar DC-DC converter. This system can intelligently and efficiently operate in islanding mode when load shedding is employed to regulate the DC bus voltage with providing the demand response requirements. Also, this enables controllable loads to ride-through grid outages, and it can be used as a retrofit solution for existing topologies applicable to any type of controllable DC loads with increasing the efficiency and improving the reliability. The primary simulation results are presented for a system in both grid tied and islanded mode indicates that the proposed system can satisfactorily regulate the common bus voltage, and ride through the blackout.
LAB-OMICS AND PROGNOSTIC MARKERS (2012)

High-grade glioma is the most common brain tumor in adults, and the prognosis for patients diagnosed with this type of cancer is still poor. The biological behavior of the tumors is correlated to t ...
Complexity Control for Real-Time Video Coding (2007)

A methodology for complexity scalable video encoding and complexity control within the framework of the H.264/AVC video encoder is presented. To yield good rate-distortion performance under strict complexity/time constraints for instance in real-time communication, a framework for optimal complexity allocation at the macroblock level is necessary. We developed a macroblock level fast motion estimation based complexity scalable motion/mode search algorithm where the complexity is adapted jointly by parameters that determine the aggressiveness of an early stop criteria, the number of ordered modes searched, and the accuracy of motion estimation steps for the INTER modes. Next, these complexity parameters are adapted per macroblock based on a control loop to approximately satisfy an encoding frame rate target. The optimal manner of adapting the parameters is derived from prior training. Results using the developed scalable complexity H.264/AVC encoder demonstrate the benefit of adaptive complexity allocation over uniform complexity scaling.
Ion transporter mutations in Gitelmanʼs and Bartterʼs syndromes (1998)

The application of modern techniques in molecular genetics to classic diseases in clinical nephrology is highlighted by the recent description of the molecular basis of Bartter's and Gitelman's syndromes. A series of detailed studies are described that have resulted in the identification of specific mutations in four different genes, each of which causes hypokalemic alkalosis, salt wasting and hypotension. The importance of these genetic studies in understanding renal physiology and the regulation of blood pressure, and in developing new therapeutic strategies is discussed.
Development of 300 MW frequency converter (2010)

An extremely high-reliability 300 MW frequency converter has been developed. To achieve high reliability, the frequency converter adopts several dual (redundant) methods. The fault-system-lock function and the online recovery function greatly enhance the system reliability, allowing the Shin-Shinano FC to continue to operate almost without any stoppages due to faults. High-volume, non-volatile CPLDs are utilized in the controller, and a simple controller configuration is also achieved, which makes maintenance easy.
Data Supplement from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen (2023)

Data Supplement from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells (2021)

N-methyl-D-aspartate (NMDA) receptors are widely expressed in the central nervous system. However, their presence and function at extraneuronal sites is less well characterized. In the present study, we examined the expression of NMDA receptor subunit mRNA and protein in human pulmonary artery (HPA) by quantitative polymerase chain reaction (PCR), immunohistochemistry and immunoblotting. We demonstrate that both GluN1 and GluN2 subunit mRNAs are expressed in HPA. In addition, GluN1 and GluN2 (A-D) subunit proteins are expressed by human pulmonary artery smooth muscle cells (HPASMCs) in vitro and in vivo. These subunits localize on the surface of HPASMCs and form functional ion channels as evidenced by whole-cell patch-clamp electrophysiology and reduced phenylephrine-induced contractile responsiveness of human pulmonary artery by the NMDA receptor antagonist MK801 under hypoxic condition. HPASMCs also express high levels of serine racemase and vesicular glutamate transporter 1, suggesting a potential source of endogenous agonists for NMDA receptor activation. Our findings show HPASMCs express functional NMDA receptors in line with their effect on pulmonary vasoconstriction, and thereby suggest a novel therapeutic target for pharmacological modulations in settings associated with pulmonary vascular dysfunction.
Performance evaluation of multiscale vessel enhancement filtering (2004)

In this paper we present and evaluate the Multiscale Vessel Enhancement Filtering algorithm that has previously been reported in the literature. The criteria we use include 2D and 3D images, where sensitivity to rotation and scale are measured. We demonstrate our implementation of the algorithm on simulated and real Computed Tomography data of the liver. We find that the algorithm is relatively insensitive to vessel orientation and scale, when the tube is isolated on a dark background. Specifically, our implementation correctly detected the scale and orientation of simulated tubes. We found that many artifacts were created when the algorithm was applied to a segmented liver that contained contrast enhanced vessels.