gebhart/patrepeval huggingface dataset:
Electromigration in Power Devices (2020)

Abstract In the power semiconductor industry, there is continuous development towards higher maximum current capability of devices while device dimensions shrink. This leads to an increase in current density which the devices have to handle, and raises the question if electromigration (EM) is a critical issue here. Generally, an EM failure can be described by the Black’s equation with temperature and current density as the main influencing factors. Normally, the current that the power packages need to handle lies in the range of 100 A. However, it should be noted that power devices exhibit asymmetric sizes of drain and source contacts. This may lead to higher current density at the source leads (area ratio drain/source: ~8x for QFN 5×6). Nevertheless, the source lead area is still much larger than that of the flip chip bumps (i.e., 28 times larger compared to a 100 μm micro-bump). This typically enhances the safety of the power device with respect to EM. However, with regard to future development towards higher maximum current capability, we intended to investigate further on the EM of power devices. In the present work, we focused on the PQFN 5×6 package to study the EM behavior of a power device soldered on a Printed Circuit Board (PCB). We employed the highest current (120 A) and temperature (150 °C) that the stress test system could handle to study EM in accelerated mode. First fails occurred after ~1200 h, which was much earlier than expected from previous flip-chip investigations. In addition, we found separation gaps in the solder joint between drain contact and PCB, which experienced the lowest current density in the whole test. Contradictorily, we observed only minor solder degradation at the source interface, regardless of the higher current density there. Nevertheless, the separating metal interfaces still correlated well with the current direction. Thermal simulations revealed that due to the self-heating of the device by the high current applied, both the drain and source leads were exposed to much higher temperatures (Tmax = 168 °C) than the PCB board which was kept under temperature control at 150 °C. This temperature difference resulted in a thermal gradient between the device and PCB which, in turn, triggered thermal migration (TM) in addition to EM. As TM for the drain contact occurred in the same direction as EM, it enhanced the degradation effect and therefore led to a shorter time-to-failure at the drain. In contrast to this, such an enhanced effect did not occur at the source side. As a result, we observed higher solder degradation at the drain side, which we did confirm by switching the current direction in the test. To minimize the TM effect, a special EM test vehicle, which used a Cu plate instead of the MOSFET chip, was designed and fabricated. Thermal simulation verified that the device operated at similar temperatures as the PCB board. Using this setup, it was possible to study EM in an accelerated mode and, thus, investigate the pure EM behavior of the power device.
Serial Quantization for Representing Sparse Signals (2019)

Sparse signals are encountered in a broad range of applications. In order to process these signals using digital hardware, they must be first quantized using an analog-to-digital convertor (ADC), which typically operates in a serial scalar manner. In this work we propose a method for serial quantization of sparse signals (SeQuanS) inspired by group testing theory, which is designed to reliably and accurately quantize sparse signals acquired in a sequential manner using serial scalar ADCs. Unlike previously proposed approaches which combine quantization and compressed sensing (CS), our SeQuanS scheme updates its representation on each incoming analog sample and does not require the complete signal to be observed and stored in analog prior to quantization. We characterize the asymptotic tradeoff between accuracy and quantization rate of SeQuanS as well as its computational burden. Our numerical results demonstrate that SeQuanS is capable of achieving substantially improved representation accuracy over previous CS-based schemes without requiring the complete set of analog signal samples to be observed prior to its quantization, making it an attractive approach for acquiring sparse time sequences.
Integrative Oncology in Cancer Care (2017)

Overview Integrative medicine seeks to merge conventional medicine and complementary therapies in a manner that is comprehensive, personalized, evidence based, and safe. Integrative oncology is the term used to describe the application of integrative medicine to cancer care. The field of integrative oncology is a constantly evolving set of disciplines. This chapter reviews the role of integrative medicine in cancer care with an emphasis on effective communication, an overview of the evidence, integrative‐based resources to guide health care providers and patients, and presents a model of how to effectively incorporate integrative medicine within cancer care. Existing research suggests that the majority of cancer patients desire communication with their physicians about integrative medicine. It is the healthcare professional's responsibility to ask patients about their use of complementary medicines and to provide evidence‐based advice to guide patients in this evolving area. Key findings in the areas of mind‐body practices, massage, and acupuncture are presented. Mind‐body practices help to improve mood, sleep quality, physical functioning, and overall well‐being. Massage is helpful at relieving pain, anxiety, and increasing relaxation. Acupuncture has the greatest evidence to support its use in managing symptoms such as chemotherapy‐induced nausea, vomiting, and pain; initial research suggests benefit in providing relief for radiation‐induced xerostomia and other symptoms. Many authoritative resources now exist to help guide patients' appropriate use of complementary therapies, allowing the medical team to follow evidence‐based guidelines.
Genetic Divergence with Emergence of Novel Phenotypic Variants of Equine Arteritis Virus during Persistent Infection of Stallions (1999)

The persistently infected carrier stallion is the critical natural reservoir of equine arteritis virus (EAV), as venereal infection of mares frequently occurs after breeding to such stallions. Two Thoroughbred stallions that were infected during the 1984 outbreak of equine viral arteritis in central Kentucky subsequently became long-term EAV carriers. EAV genomes amplified from the semen of these two stallions were compared by sequence analysis of the six 3' open reading frames (ORFs 2 through 7), which encode the four known structural proteins and two uncharacterized glycoproteins. The major variants of the EAV population that sequentially arose within the reproductive tract of each carrier stallion varied by approximately 1% per year, and the heterogeneity of the viral quasispecies increased during the course of long-term persistent infection. The various ORFs of the dominant EAV variants evolved independently, and there was apparently strong selective pressure on the uncharacterized GP3 protein during persistent infection. Amino acid changes also occurred in the V1 variable region of the GL protein. This region has been previously identified as a crucial neutralization domain, and selective pressures exerted on the V1 region during persistent EAV infection led to the emergence of virus variants with distinct neutralization properties. Thus, evolution of the EAV quasispecies that occurs during persistent infection of the stallion clearly can influence viral phenotypic properties such as neutralization and perhaps virulence.
ChemInform Abstract: Preparation of a Novel P‐P‐Bonded Diphosphine. (1986)

Abstract Die Einführung der n‐Hexylgruppe in das wie aufgezeichnet als Isomerengemisch gebildete, sek., bicyclische Phosphin (II) gelingt durch Deprotonierung des intermediären Phosphoniumsalzes (III); das tert. n‐Hexylphosphin (IV) entsteht mit guter Ausbeute.
Regulation of Insulin-Like Growth Factor I and Stage-Specific Levels of Epidermal Growth Factor in Stage Synchronized Rat Testes (1990)

Stage synchronization of seminiferous epithelium after withdrawal and replenishment of vitamin A provides a valuable and powerful approach to the investigation of paracrine interactions within the testis. However, since the discovery of this model, little attention has been given to the events surrounding the synchronous reinitiation of spermatogenesis after depletion of vitamin A. Synchronization of spermatogenesis was observed in all animals previously deficient in vitamin A. However, the degree of synchrony observed, as assessed by a ratio of synchrony, decreased markedly with time. The possibility that spermatogenic synchrony decreases with time due to variability of the temporal duration of stages of the cycle of the seminiferous epithelium is supported by this observation. However, long-term studies are required to substantiate this point. After initiation of stage synchrony of spermatogenesis, increased testicular concentrations of epidermal growth factor (EGF) were observed in testes synchronized between stages IX-II than at other stages of the cycle of the seminiferous epithelium. This elevation in testicular EGF concentrations correlated well with mitotic division of type A spermatogonia at stages IX, XII, and XIV of the cycle of the seminiferous epithelium. Previous in vitro studies have implicated an EGF-like factor in the stimulation of type A spermatogonial division in the mouse. A significant increase in testicular insulin-like growth factor I (IGF-I) concentrations was observed in control animals 14 days after the injection of retinol acetate. In vitamin A deficient animals, a marked increase in testicular IGF-I concentrations was observed as compared to age-matched controls. Maximal levels of testicular IGF-I concentrations were present 14 and 28 days and again 126 days after re-supplementation with retinol acetate. No stage dependent changes in testicular IGF-I were observed but the data provided suggest the retinol may be one of the factors involved in the regulation of testicular IGF-I.
Optimization of sugar beet pulp enzymatic treatment for different bioprocesses (2012)

Sugar beet pulp (SBP) was hydrolyzed with combinations of commercially available fungal enzymes (Ultrazym AFP-L, Viscozyme L, Pectinase and Cellulase) and wood-rotting fungi (Trametes multicolor, Sclerotium rolfsii and Neurospora crassa) lignocellulolytic enzymes. Among the tested enzymes, the plant pathogen Sclerotium rolfsii was found to be the best-performing fungus and it was chosen for further research. Current research activities were focused on the optimization of the hydrolytic process using a factorial design approach and response surface methodology (RSM). The effect of various experimental parameters and their interactions with each other was evaluated using those methods and consequently the optimum conditions were accomplished. The set-up parameters were the enzyme loads (1, 2, 3, 4 μL total enzymes / mg SBP), pH (3, 4, 5, 6, 7) and temperature (20, 30, 40, 50 oC). Using statistical design methodology, it was observed dramatically reduce of the required enzyme loads to only 2 μL total enzymes / g SBP, at the optimal pH and temperature value. Optimal parameters of hydrolytic process would apply in the further investigation of SBP hydrolysis to obtain more economical process for biofuels, biopolymers or biochemicals production.
The latest word in digital and media processing (1998)

The article discusses the technology behind the resurgence of DSP oriented microprocessors and the techniques that allow one to use them well. After an overview of the VLIW architecture, it discusses three main areas: VLIW architectural feature relevant to DSP applications; their associated complier techniques; and coding techniques that allow the application programmer, while still coding in a high-level language, to best exploit the architecture.
GlycoChip™ - high throughput technology for screening and analysis of protein-glycan interactions (2002)

Conference Abstract| February 01 2002 GlycoChip™ - high throughput technology for screening and analysis of protein-glycan interactions A. Gargir; A. Gargir 1Glycominds Ltd., Renanim Center, P.O. Box 11407, Maccabim 71908 Israel Search for other works by this author on: This Site PubMed Google Scholar A Shtevi; A Shtevi 1Glycominds Ltd., Renanim Center, P.O. Box 11407, Maccabim 71908 Israel Search for other works by this author on: This Site PubMed Google Scholar M. Gortler; M. Gortler 1Glycominds Ltd., Renanim Center, P.O. Box 11407, Maccabim 71908 Israel Search for other works by this author on: This Site PubMed Google Scholar A. Dukler; A. Dukler 1Glycominds Ltd., Renanim Center, P.O. Box 11407, Maccabim 71908 Israel Search for other works by this author on: This Site PubMed Google Scholar N. Dotan N. Dotan 1Glycominds Ltd., Renanim Center, P.O. Box 11407, Maccabim 71908 Israel Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2002) 30 (1): A4. https://doi.org/10.1042/bst030a004c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A. Gargir, A Shtevi, M. Gortler, A. Dukler, N. Dotan; GlycoChip™ - high throughput technology for screening and analysis of protein-glycan interactions. Biochem Soc Trans 1 February 2002; 30 (1): A4. doi: https://doi.org/10.1042/bst030a004c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2002 Biochemical Society2002 Article PDF first page preview Close Modal You do not currently have access to this content.
Thermodynamically stable, size selective solubilization of carbon nanotubes in aqueous solutions of amphiphilic block copolymers (2009)

Two molecular modes of amphiphilic block copolymer-carbon nanotube interactions have been identified in the literature, one involving the adsorption of individual block copolymer molecules on the carbon nanotubes and the other involving the adsorption of multimolecular, spherical micelles. In both cases, the nature of stability imparted to the dispersion of carbon nanotubes in the aqueous medium is kinetic, controlled by the steric barrier imposed by the adsorbed individual block copolymer molecules or the adsorbed micelles. In this study, we propose another mode of molecular interaction, wherein the block copolymer molecules self-assemble around the nanotube, generating aggregates in which the nanotubes are solubilized. In this case, the resulting system is a thermodynamically stable nanocolloidal solution, similar to aqueous surfactant solutions, in contrast to the kinetically stabilized nanotube dispersions. To examine whether such solubilization of nanotubes is possible, we have constructed a simple phenomenological theory for the free energy change associated with solubilization and have performed illustrative numerical simulations based on the theory. The calculated results for the commercially available symmetric PEO-PPO-PEO triblock copolymers and for the PEO-PPO diblock copolymers having the same composition and molecular weight as the triblocks show that indeed the block copolymer molecules are capable of solubilizing the carbon nanotubes. While the block copolymers whose natural curvature is cylindrical are the best candidates to solubilize the nanotubes, other block copolymers whose natural curvature is spherical or lamellar, are also found capable of solubilizing the nanotubes. Most interestingly, the solubilization is found to be size specific suggesting that this can be developed into a practical method to fractionate carbon nanotubes by their diameter. These results are applicable to both single-walled and multiwalled carbon nanotubes and the general conclusions are valid also for other diblock and triblock copolymers.
Sequential Infiltration Synthesis for Line Edge Roughness Mitigation of EUV Resist (2017)

It is well known that high line-edge roughness (LER) and line-width roughness (LWR) are one of the key problems hindering utilization of extreme ultraviolet lithography (EUVL) in fabrication of semiconductor devices at advanced technology nodes where pattern with sub-20 nm half pitch lines and spaces is required. Sequential infiltration synthesis (SIS) has never been used before in lithography for line-edge roughness mitigation, but this concept has proved its value for 14 nm half pitch block copolymer lines formed by directed self-assembly. During this process an inorganic scaffold is being deposited inside the resist material after performing several sequential infiltration cycles with metal-organic precursor and its oxidizing agent. Etching in oxygen atmosphere after is required to transform former resist pattern into metal oxide one and improve (up to 40%) the pattern roughness. In this paper, for the first time we demonstrate feasibility of sequential infiltration synthesis (SIS) for smoothing of EUV resist lines.
Temporal correlation detection using computational phase-change memory (2017)

Conventional computers based on the von Neumann architecture perform computation by repeatedly transferring data between their physically separated processing and memory units. As computation becomes increasingly data centric and the scalability limits in terms of performance and power are being reached, alternative computing paradigms with collocated computation and storage are actively being sought. A fascinating such approach is that of computational memory where the physics of nanoscale memory devices are used to perform certain computational tasks within the memory unit in a non-von Neumann manner. We present an experimental demonstration using one million phase change memory devices organized to perform a high-level computational primitive by exploiting the crystallization dynamics. Its result is imprinted in the conductance states of the memory devices. The results of using such a computational memory for processing real-world data sets show that this co-existence of computation and storage at the nanometer scale could enable ultra-dense, low-power, and massively-parallel computing systems.
V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1 (2015)

The N160 glycan-V1/V2 site is the most conserved neutralizing site within the 4 groups of HIV-1. This makes it an interesting target for the development of HIV vaccine immunogens. The corresponding bNAbs may be useful for immunotherapeutic strategies in patients infected by non-M variants.
PP2A: The Achilles Heal in MDS with 5q Deletion (2014)

Myelodysplastic syndromes (MDS) represent a hematologically diverse group of myeloid neoplasms, however, one subtype characterized by an isolated deletion of chromosome 5q [del(5q)] is pathologically and clinically distinct. Patients with del(5q) MDS share biological features that account for the profound hypoplastic anemia and unique sensitivity to treatment with lenalidomide. Ineffective erythropoiesis in del(5q) MDS arises from allelic deletion of the ribosomal processing S-14 (RPS14) gene, which leads to MDM2 sequestration with consequent p53 activation and erythroid cell death. Since its approval in 2005, lenalidomide has changed the natural course of the disease. Patients who achieve transfusion independence and/or a cytogenetic response with lenalidomide have a decreased risk of progression to acute myeloid leukemia and an improved overall survival compared to non-responders. Elucidation of the mechanisms of action of lenalidomide in del(5q) MDS has advanced therapeutic strategies for this disease. The selective cytotoxicity of lenalidomide in del(5q) clones derives from inhibition of a haplodeficient phosphatase whose catalytic domain is encoded within the common deleted region on chromosome 5q, i.e., protein phosphatase 2A (PP2Acα). PP2A is a highly conserved, dual specificity phosphatase that plays an essential role in regulation of the G2/M checkpoint. Inhibition of PP2Acα results in cell-cycle arrest and apoptosis in del(5q) cells. Targeted knockdown of PP2Acα using siRNA is sufficient to sensitize non-del(5q) clones to lenalidomide. Through its inhibitory effect on PP2A, lenalidomide stabilizes MDM2 to restore p53 degradation in erythroid precursors, with subsequent arrest in G2/M. Unfortunately, the majority of patients with del(5q) MDS develop resistance to lenalidomide over time associated with PP2Acα over-expression. Targeted inhibition of PP2A with a more potent inhibitor has emerged as an attractive therapeutic approach for patients with del(5q) MDS.
Deformation, fatigue and fracture behavior of two cast anisotropic superalloys (1987)

Tensile and low cycle fatigue (LCF) tests were conducted on two cast anisotropic superalloys. The effects of temperature, strain rate and stress range were investigated. Deformation behavior was extensively characterized and modeled. LCF and fracture behavior were studied and correlated with deformation behavior.
ChemInform Abstract: The Addition of Diallylzinc to 5‐Substituted 4,5‐Dihydroisoxazoles. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Convergent, Parallel Synthesis of a Series of β‐Substituted 1,2,4‐Oxadiazole Butanoic Acids as Potent and Selective αvβ3 Receptor Antagonist. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing (2015)

West Nile virus (WNV) infection is an emerging mosquito-borne disease that can lead to severe neurological illness and currently has no available treatment or vaccine. Using microengraving, an integrated single-cell analysis method, we analyzed a cohort of subjects infected with WNV - recently infected and post-convalescent subjects - and efficiently identified four novel WNV neutralizing antibodies. We also assessed the humoral response to WNV on a single-cell and repertoire level by integrating next generation sequencing (NGS) into our analysis. The results from single-cell analysis indicate persistence of WNV-specific memory B cells and antibody-secreting cells in post-convalescent subjects. These cells exhibited class-switched antibody isotypes. Furthermore, the results suggest that the antibody response itself does not predict the clinical severity of the disease (asymptomatic or symptomatic). Using the nucleotide coding sequences for WNV-specific antibodies derived from single cells, we revealed the ontogeny of expanded WNV-specific clones in the repertoires of recently infected subjects through NGS and bioinformatic analysis. This analysis also indicated that the humoral response to WNV did not depend on an anamnestic response, due to an unlikely previous exposure to the virus. The innovative and integrative approach presented here to analyze the evolution of neutralizing antibodies from natural infection on a single-cell and repertoire level can also be applied to vaccine studies, and could potentially aid the development of therapeutic antibodies and our basic understanding of other infectious diseases.