gebhart/patrepeval huggingface dataset:
Peptide Delivery to Tissues via Reversibly Linked Protein Transduction Sequences (2002)

The development of peptide-based therapeutics has suffered from challenges associated with delivery to intact tissue. In skin, an array of protein targets resides only tens of micrometers below the surface; however, because of difficulties in traversing the cutaneous barrier, the potentialfor peptide-based therapeutics remains unrealized. We have developed a general approach for topical peptide delivery into skin using releasable protein transduction sequences to enable peptide transport across tissue boundaries. Upon entry into the cell, the disulfide linkage between the peptide transduction sequences and peptide cargo is cleaved, permitting the dissociation of the highly charged peptide transduction sequences from the active peptide. A protype cargo peptide, the hemagglutinin (HA) epitope, was conjugated to a hepta-arginine protein transduction sequence via a releasable disulfide linkage. This construct penetrated the skin to deep dermis within 1 h after topical application. Consistent with the dissociation of the protein transduction and cargo sequences, absorbed protein transduction sequences and HA peptides displayed differential intracellular localization. Reversible protein transduction sequence linkage thus represents a noninvasive platform for tissue delivery of intact peptides with no requirement for viral vectors or parenteral injection and may be of broad utility in molecular therapy.
REVERSE TOTAL SHOULDER ARTHROPLASTY (2006)

Background: Reverse total shoulder arthroplasty is currently being used to treat selected patients with disabling shoulder arthropathy. The purposes of this study were to investigate the medium-term results of reverse total shoulder arthroplasty and to analyze the influence of etiology on the result. Methods: We carried out a multicenter study with a minimum follow-up of five years and determined the survival rate of the prosthesis according to the initial etiology of the shoulder arthropathy. Eighty prostheses were implanted in seventy-seven patients between 1992 and 1998. Sixty-six shoulders had an arthropathy with a massive rotator cuff tear, and fourteen shoulders had a disorder with another etiology (rheumatoid arthritis, trauma, or revision arthropathy). At the time of review, eighteen patients had died and two were lost to follow-up. The remaining fifty-seven patients (sixty shoulders) were examined or interviewed by telephone at a mean follow-up of 69.6 months. Cumulative survival curves were generated with replacement of the prosthesis, glenoid loosening, and a functional Constant score of <30 as the end points. Results: The survival rate with replacement of the prosthesis and glenoid loosening as the end points were 91% and 84%, respectively, at 120 months, with shoulders that had arthropathy with a massive rotator cuff tear demonstrating a significantly better result than those that had a disorder with another etiology (p < 0.05). On the other hand, the survival rate with an absolute Constant score of <30 as an end point was 58% at 120 months, with no significant difference with respect to etiology. Two breaks were observed in the survival curves. The first concerned survival until replacement of the prosthesis and occurred at around three years, reflecting early loosening of the prosthesis. The curve then became stable. A second break started at around six years and reflected progressive deterioration of the functional result. Conclusions: Our findings indicate that the reverse total prosthesis should be reserved for the treatment of very disabling shoulder arthropathy with a massive rotator cuff rupture, and it should be used exclusively in patients over seventy years old with low functional demands. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease (2017)

The 2013-2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was unprecedented in the number of documented cases, but there have been few published reports on immune responses in clinical cases and their relationships with the course of illness and severity of Ebola virus disease. Symptoms of Ebola virus disease can include severe headache, myalgia, asthenia, fever, fatigue, diarrhea, vomiting, abdominal pain, and hemorrhage. Although experimental treatments are in development, there are no current U.S. Food and Drug Administration-approved vaccines or therapies. We report a detailed study of host gene expression as measured by microarray in daily peripheral blood samples collected from a patient with severe Ebola virus disease. This individual was provided with supportive care without experimental therapies at the National Institutes of Health Clinical Center from before onset of critical illness to recovery. Pearson analysis of daily gene expression signatures revealed marked gene expression changes in peripheral blood leukocytes that correlated with changes in serum and peripheral blood leukocytes, viral load, antibody responses, coagulopathy, multiple organ dysfunction, and then recovery. This study revealed marked shifts in immune and antiviral responses that preceded changes in medical condition, indicating that clearance of replicating Ebola virus from peripheral blood leukocytes is likely important for systemic viral clearance.
Measurement of pulsatile motion with millisecond resolution by MRI (2011)

We investigated a technique based on phase-contrast cine MRI combined with deconvolution of the phase shift waveforms to measure rapidly varying pulsatile motion waveforms. The technique does not require steady-state displacement during motion encoding. Simulations and experiments were performed in porcine liver samples in view of a specific application, namely the observation of transient displacements induced by acoustic radiation force. Simulations illustrate the advantages and shortcomings of the methods. For experimental validation, the waveforms were acquired with an ultrafast ultrasound scanner (Supersonic Imagine Aixplorer), and the rates of decay of the waveforms (relaxation time) were compared. With bipolar motion-encoding gradient of 8.4 ms, the method was able to measure displacement waveforms with a temporal resolution of 1 ms over a time course of 40 ms. Reasonable agreement was found between the rate of decay of the waveforms measured in ultrasound (2.8 ms) and in MRI (2.7-3.3 ms).
Mechanochemical Synthesis of Carbon Nanothread Single Crystals (2017)

Synthesis of well-ordered reduced dimensional carbon solids with extended bonding remains a challenge. For example, few single-crystal organic monomers react under topochemical control to produce single-crystal extended solids. We report a mechanochemical synthesis in which slow compression at room temperature under uniaxial stress can convert polycrystalline or single-crystal benzene monomer into single-crystalline packings of carbon nanothreads, a one-dimensional sp3 carbon nanomaterial. The long-range order over hundreds of microns of these crystals allows them to readily exfoliate into fibers. The mechanochemical reaction produces macroscopic single crystals despite large dimensional changes caused by the formation of multiple strong, covalent C–C bonds to each monomer and a lack of reactant single-crystal order. Therefore, it appears not to follow a topochemical pathway, but rather one guided by uniaxial stress, to which the nanothreads consistently align. Slow-compression room-temperature synthesis may allow diverse molecular monomers to form single-crystalline packings of polymers, threads, and higher dimensional carbon networks.
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference (2015)

The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged from zoonotic sources in 2002 and caused over 8,000 infections and 800 deaths in 37 countries around the world. Identifying host factors that regulate SARS-CoV pathogenesis is critical to understanding how this lethal virus causes disease. We have found that BST-2 is capable of restricting SARS-CoV release from cells; however, we also identified a SARS-CoV protein that inhibits BST-2 function. We show that the SARS-CoV protein ORF7a inhibits BST-2 glycosylation, leading to a loss of BST-2's antiviral function.
Warehouse-Scale Video Acceleration (2022)

Video processing is foundational to a spectrum of important workloads: video sharing, video conferencing, photos/video archival, virtual/augmented reality, cloud gaming, and live streaming. The exponential growth in these workloads, coincident with a slowing Moore’s law, poses significant challenges to deliver more computing at higher efficiencies. In this article, we present the design of a new accelerator—the video coding unit—targeted at warehouse-scale (cloud) video transcoding. Our deployment at scale in Google, the first of its kind, has demonstrated significant benefits on several products (YouTube, Meet, Stadia, Photos, etc.) serving billions of users.
Two-stage Reimplantation for Treating Prosthetic Shoulder Infections (2011)

Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.
Damping associated with incipient melting in aluminum-indium alloys. Research and development report, October 1987-February 1989 (1990)

The strain amplitude dependent damping of binary aluminum-indium alloys containing nominally 0.6 to 17.3 weight percent indium was studied. A dynamic mechanical analyzer was used to measure the damping capacity of these materials. Pure aluminum (99.99%) exhibited strain dependent damping at strain values as low as 70 microstrain. The addition of 0.6 weight percent indium reduced the strain dependent damping by a factor of 2, but the strain dependent damping was equivalent to that of pure aluminum. Binary aluminum-indium alloys containing 4, 8, 12 and 16 weight percent indium exhibited a general increase in loss factor with increasing indium content; however, the strain dependent damping was no greater than that of the pure aluminum sample. No significant increase in damping was observed when the binary alloys were tested at temperatures above the melting point of indium. Two damping peaks were observed near the eutectic melting point when tested at 10 Hz and differential scanning calorimetry verified both of these as due to the melting of the indium inclusions. It was concluded that the higher temperature damping peak was associated with smaller indium inclusions and that the damping peaks were related to the solute segregation associated with the binary eutectic reaction.
Inorganic polymer resists for EUVL (2005)

The uniqueness in extreme ultraviolet (EUV) Lithography is encouraging the development of new polymer platform as a resist material. The absorbance characteristic of materials at the EUV region demands the use of polymers containing highly transparent silicon atoms. Also very low level of outgassing is required due to the vacuum environment during exposure and the extremely high cost of the EUV tools. To fulfill those requirements, two types of silicon backbone polymers were studied; chemically amplifiable polysilanes and polysilsesquiazanes. In the former case, the direct incorporation of acid sensitive groups into the polymer backbone allows for a solubility switch upon exposure. In the later system, this nitrogen-containing silicon polymer can be cleaved upon exposure to induce a solubility switch. These polymers possess many essential properties including low absorbance, low outgassing, and high sensitivity. Polymers having different substituents and branching ratios were synthesized. The properties of the polymers will be discussed relating to their lithographic performances.
Effect of Penetrating Irradiation on Polarization Reversal in PZT Thin Films (2006)

Spatially non-uniform imprint behavior induced by X-ray synchrotron, electron, and neutron irradiation has been investigated in Pb(Zr,Ti)O3 thin films. The obtained effects have been explained as a result of acceleration of the bulk screening process induced by irradiation. It has been shown that the spatial distribution of the internal bias field is determined by the domain pattern existing during irradiation. The microstructural changes in the structural characteristics during fatigue cycling have been revealed by high resolution synchrotron X-ray diffraction experiments. Their correlation with the evolution of the switching characteristics has been revealed and discussed.
New bad-data detection and identification technique based on rotation of measurement order for sequential state estimation (1992)

The paper describes the development of a new bad-data detection and identification technique for sequential state estimations using Givens orthogonal transformation. In the sequential state estimation, measurements are divided into basic measurements and redundant ones. Basic measurements are processed first, and then redundant ones are processed one at a time. The successive change in the cost quadratic function, denoted by δJ, resulting from the processing of a redundant measurement, follows a Chi-square distribution with one degree of freedom. If there are no gross errors in the measurements processed up to the present point, then δJ is free from the contamination of gross errors in the measurements which are waiting to be processed. Furthermore, δJ shows the degree of consistency between the present measurement and those processed before. Hence, the bad-data detection by δJ test is performed, after one measurement has been processed, by comparing the value of δJ with a constant obtained from the Chi-square distribution. The new bad-data identification method is based on the fact that despite the existence of a few gross errors, most of the measurements are ‘good’ in the sense that they are corrupted by Gaussian noise only. Thus, by searching for these ‘good’ ones and processing them first, suspect measurements are isolated to the bottom of the measurement list. This is done by successively rotating the order of measurements while they are being processed. The proposed bad-data detection and identification method does not rely on the analysis of measurement residuals. The new bad-data processing technique is tested on an industrial steam turbine system for which a robust and efficient state estimator has been developed. Numerical results for bad-data detection and identification tests are reported.
Supplemental Table S2 and Table S3 from Loss of <i>ARID1A</i> Activates <i>ANXA1</i>, which Serves as a Predictive Biomarker for Trastuzumab Resistance (2023)

&lt;p&gt;Supplemental Table S2: Patient characteristics FinHer Supplemental Table S3: Patient characteristics Responsify&lt;/p&gt;
Nomenclature of Eukaryotic DNA Polymerases (1975)

A nomenclature system is proposed for the various DNA-polymerase activities now known to exist in eukaryotic cells.
Perioperative buffered versus non-buffered fluid administration for surgery in adults (2003)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To review the effects of perioperative intravascular administration of buffered versus non‐buffered fluids for plasma volume expansion, on clinical outcome in adult patients undergoing all types of surgery.
Study of magnetic tunnel junction read sensors (2001)

Unshielded magnetic tunnel junction (MTJ) sensors stabilized by insulating hard magnetic tails have been fabricated. Testing results showed that the control of oxidation condition was important for obtaining MTJ with low junction resistances and high TMR coefficients. The results also showed that the thickness of insulating spacer between hard magnet and MTJ stack had a significant influence on sensor stability. Finally, recording tests of stabilized MTJ read heads demonstrated linear densities of 420 Kbpi at 10/sup -9/ ontrack error.
111 In Vivo Performance of a Microfabricated Catheter for Intraparenchymal Delivery (2014)

INTRODUCTION: Convection-enhanced delivery (CED) is an effective technique to bypass the blood-brain barrier (BBB) and deliver drugs directly into the brain parenchyma. However, several technical limitations must be addressed to increase its efficiency, repeatability, and effectiveness in clinical practice. METHODS: This study reports infusions of tracers of various sizes into the brain of a large mammal (pig) using a novel microfabricated catheter. Standard stereotactic procedures were used using the Medtronic Navigus Trajectory Guide kit to target the anatomy. Infusions through the microcatheter at various infusion rates were evaluated for possible backflow or reflux up the outside of the catheter, which has proved to be a problem in CED infusions, especially at high infusion rates. Real-time magnetic resonance (MR) imaging was used to examine the distributions of the tracers and their concentration profiles in the parenchyma. In-line catheter pressures were monitored for all infusions. Infusions were carried out in porcine white matter, thalamus, and putamen. RESULTS: The extent of backflow, if any, and concentration profiles were determined for several MR contrast reagents and fluorescent dyes with sizes that are typical of small molecules, therapeutic proteins and an adeno-associated virus (AAV). Infusion flowrates up to 40 μL/min were achieved without evidence of backflow of infusate along the catheter. The ratio of the volume of distribution in tissue to the infusion volume (Vd/Vi) was similar for all infused reagents. The in-line pressures were consistent with theoretical values for flow through a micro-lumen. CONCLUSION: The microfabricated catheter was able to target different cytoarchitectures with precision using standard functional stereotactic techniques and deliver small and large molecules at high infusion rates without evidence of backflow. The measured distribution volumes indicated that all infusates were readily convected through the interstitial space regardless of molecular size.
Design of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination (2015)

The CuH-catalyzed hydroamination of alkenes and alkynes using a silane and an amine transfer reagent represents a simple strategy to access chiral amine products. We have recently reported methods to prepare chiral amines with high efficiency and stereoselectivity using this approach. However, the current technology is limited to the synthesis of trialkylamines from dialkylamine transfer reagents (R2NOBz). When monoalkylamine transfer reagents [RN(H)OBz] were used for the synthesis of chiral secondary amines, competitive, nonproductive consumption of these reagents by the CuH species resulted in poor yields. In this paper, we report the design of a modified type of amine transfer reagent that addresses this limitation. This effort has enabled us to develop a CuH-catalyzed synthesis of chiral secondary amines using a variety of amine coupling partners, including those derived from amino acid esters, carbohydrates, and steroids. Mechanistic investigations indicated that the modified amine transfer reagents are less susceptible to direct reaction with CuH.
Mean-field lattice equations of state. III. Modeling the phase behavior of supercritical gas-polymer mixtures (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMean-field lattice equations of state. III. Modeling the phase behavior of supercritical gas-polymer mixturesEric J. Beckman, Ronald Koningsveld, and Roger S. PorterCite this: Macromolecules 1990, 23, 8, 2321–2329Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ma00210a031https://doi.org/10.1021/ma00210a031research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dilution Effects on Chemical and Magnetic Clusters of α-LiFeO2 (2004)

We have synthesized α-LiFe1-xInxO2 (x = 0, 0.001, 0.01, 0.05, and 0.1) powders by calcination of Li2CO3, Fe2O3 and In2O3 mixtures. In X-ray diffraction, the sample with larger x value showed larger lattice constant of the cubic NaCl-type structure. Aside from electron diffraction patterns of the cubic unit cell with diffuse scattering for both the samples, the x = 0 sample demonstrated a doubled structure of the cubic unit cell with wavy diffuse scattering, though the x = 0.1 sample exhibited the doubled structure with less intensive diffuse scattering. In cooling history-dependent dc susceptibilities, the bifurcation point of the x = 0 sample was ≈90 K, and it lowered from 87 to 44 K with increasing the x value from 0.001 to 0.1. Dilution of α-LiFeO2 with nonmagnetic In3+ ions suppressed chemical cluster formation at room temperature and reduced temperature of ferromagnetic cluster formation.
Organic Field-Effect Transistor Integrated Circuits using Self-Alignment Process Technology (2007)

Organic field-effect transistor (OFET) integrated circuits have been investigated by applying a self-alignment process technology. In order to obtain a larger logic swing and shorter switching time, a level-shift inverter with a super-buffer configuration was adopted. The circuit parameters were optimized and then a seven-stage ring oscillator with a channel length of 9 µm was fabricated. The obtained propagation delay was 24 µs/stage, which will be improved to 2–3 µs/stage by miniaturizing the channel length and upgrading the carrier mobility.
Unraveling the ultralow threshold stimulated emission from CdZnS/ZnS quantum dot and enabling high‐Q microlasers (2015)

Abstract The newly engineered ternary CdZnS/ZnS colloidal quantum dots (CQDs) are found to exhibit remarkably high photoluminescence quantum yield and excellent optical gain properties. However, the underlying mechanisms, which could offer the guidelines for devising CQDs for optimized photonic devices, remain undisclosed. In this work, through comprehensive steady‐state and time‐resolved spectroscopy studies on a series of CdZnS‐based CQDs, we unambiguously clarify that CdZnS‐based CQDs are inherently superior optical gain media in the blue spectral range due to the slow Auger process and that the ultralow threshold stimulated emission is enabled by surface/interface engineering. Furthermore, external cavity‐free high‐Q quasitoroid microlasers were produced from self‐assembly of CdZnS/ZnS CQDs by facile inkjet printing technique. Detailed spectroscopy analysis confirms the whispering gallery mode lasing mechanism of the quasitoroid microlasers. This tempting microlaser fabrication method should be applicable to other solution‐processed gain materials, which could trigger broad research interests. image