gebhart/patrepeval huggingface dataset:
iSkin (2015)

We propose iSkin, a novel class of skin-worn sensors for touch input on the body. iSkin is a very thin sensor overlay, made of biocompatible materials, and is flexible and stretchable. It can be produced in different shapes and sizes to suit various locations of the body such as the finger, forearm, or ear. Integrating capacitive and resistive touch sensing, the sensor is capable of detecting touch input with two levels of pressure, even when stretched by 30% or when bent with a radius of 0.5cm. Furthermore, iSkin supports single or multiple touch areas of custom shape and arrangement, as well as more complex widgets, such as sliders and click wheels. Recognizing the social importance of skin, we show visual design patterns to customize functional touch sensors and allow for a visually aesthetic appearance. Taken together, these contributions enable new types of on-body devices. This includes finger-worn devices, extensions to conventional wearable devices, and touch input stickers, all fostering direct, quick, and discreet input for mobile computing.
Economic Versus Statistical Clustering in Multi-Asset Multi-Factor Strategies (2020)

Maximizing for diversification in the multi-asset multi-factor universe, the literature advances diversified risk parity strategies across economic clusters. For handling overly complex correlation matrices, hierarchical clustering techniques have recently been put forward to guide risk parity allocations. Indeed, such statistical clusters might be considered natural portfolio building blocks given that they automatically pick up the dependence structure and thus form meaningful ingredients to aid portfolio diversification. We explain the intuition and nature of hierarchical clustering techniques in the context of multi-asset multi-factor investing vis-a-vis the use of economic factors in diversified risk-based allocation paradigms such as 1/N, minimum-variance and diversified risk parity.
Increasing plant growth by modulating omega-amidase expression in plants (2023)

The present disclosure relates to compositions and methods for increasing the leaf-to-root ratio of the signal metabolite 2-oxoglutaramate and related proline molecules in plants by modulating levels of .omega.-amidase to increase nitrogen use efficiency, resulting in enhanced growth, faster growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, increased tolerance to high salt conditions, and increased biomass yields.
Pinched-flow hydrodynamic stretching of single-cells (2013)

Reorganization of cytoskeletal networks, condensation and decondensation of chromatin, and other whole cell structural changes often accompany changes in cell state and can reflect underlying disease processes. As such, the observable mechanical properties, or mechanophenotype, which is closely linked to intracellular architecture, can be a useful label-free biomarker of disease. In order to make use of this biomarker, a tool to measure cell mechanical properties should accurately characterize clinical specimens that consist of heterogeneous cell populations or contain small diseased subpopulations. Because of the heterogeneity and potential for rare populations in clinical samples, single-cell, high-throughput assays are ideally suited. Hydrodynamic stretching has recently emerged as a powerful method for carrying out mechanical phenotyping. Importantly, this method operates independently of molecular probes, reducing cost and sample preparation time, and yields information-rich signatures of cell populations through significant image analysis automation, promoting more widespread adoption. In this work, we present an alternative mode of hydrodynamic stretching where inertially-focused cells are squeezed in flow by perpendicular high-speed pinch flows that are extracted from the single inputted cell suspension. The pinched-flow stretching method reveals expected differences in cell deformability in two model systems. Furthermore, hydraulic circuit design is used to tune stretching forces and carry out multiple stretching modes (pinched-flow and extensional) in the same microfluidic channel with a single fluid input. The ability to create a self-sheathing flow from a single input solution should have general utility for other cytometry systems and the pinched-flow design enables an order of magnitude higher throughput (65,000 cells s(-1)) compared to our previously reported deformability cytometry method, which will be especially useful for identification of rare cell populations in clinical body fluids in the future.
VP8 as RTCWEB Mandatory to Implement (2013)

This document recommends that the RTCWEB working group choose the VP8
specification as a mandatory to implement video codec for RTCWEB
implementations. This document is not intended for publication as an
RFC.
Alkyne Complexes of Rhenium in Intermediate Oxidation States; Synthesis and Molecular Structure of a Rhenium(V)‐Allenylidene Complex (1987)

The ReIV complex 1 undergoes disproportion upon reaction with 2-butyne to give the allylidene-ReV complex 2 and the alkyne-ReIII complex 3. According to an X-ray structure analysis 2 does not have a metallacyclobu-tene structure; rather, the C4 ligand is bound in a carbene/olefin fashion. Reaction of 3 with AgSbF6 in the presence of alkynes leads to bis(π-alkyne) complexes, which are of interest as model compounds for intermediates of oxidative alkyne coupling
25380 Cholecystokinin-B Receptor -Mediates Growth of Hepatocellular Carcinoma (2021)

ABSTRACT IMPACT: Cholecystokinin-B Receptor -Mediates Growth of Hepatocellular Carcinoma with the use proglumide. Proglumide is a non-selective antagonistic drug therefore, strategies that block signaling at the CCK-BR may provide to be a novel therapeutic option for Hepatocellular Carcinoma treatment OBJECTIVES/GOALS: Cholecystokinin (CCK)and gastrin mediate the growth of Hepatocellular Carcinoma (HCC) through CCK-R and interruption of this signaling pathway could decrease HCC. CCK-Receptors are overexpressed in HCC and proliferation may be mediated through CCK-B. Blockade of the CCK-BR with proglumide decreased both growth in vitro and tumor growth in vivo. METHODS/STUDY POPULATION: RNA was extracted from murine Hepa1-6, RIL-175 and human HepG2 cells and was evaluated by qRT-PCR for expression of CCK-AR, CCK-BR and gastrin. CCK-R protein expression was analyzed by flow cytometry. HCC cells were treated in vitro with CCK peptide, the CCK-AR antagonist or the CCK-BR antagonist. Proliferation of selective CCK-R KO cells was compared to that of wild-type cells. To determine the effect of a CCK-R antagonist on tumor growth in vivo two cohorts of mice bearing subcutaneous Hepa1-6 or RIL-175 HCC tumors were treated with an oral bioavailable CCK-R antagonist proglumide or untreated water for 3-4 weeks. The mice bearing Hepa1-6 tumors were placed on a high-fat diet to raise blood CCK levels. Mice bearing RIL-175 tumors were fed standard chow to determine if proglumide could block autocrine growth by gastrin. RESULTS/ANTICIPATED RESULTS: The mRNA expression of CCK-AR, CCK-BR and gastrin were increased 80-90-fold in all HCC cell lines compared to that of normal liver. CCK-BRs were detected on &gt;85% of the cells by flow cytometry. CCK peptide (1nM) stimulated HCC growth in vitro in both wild-type cells and in CCK-AR KO cells but not in CCK-BR KO cells. CCK-BR antagonist blocked CCK-stimulated growth in vitro but the CCK-AR antagonist did not, suggesting that the CCK-BR was responsible for mediating proliferation. In vivo tumor growth was significantly reduced with proglumide treatment by 70% (p&lt;0.05) in Hepa1-6 and by 73% (p&lt;0.001) in RIL-75 tumors, respectively. DISCUSSION/SIGNIFICANCE OF FINDINGS: CCK-Rs are overexpressed in HCC and proliferation appears to be mediated through the CCK-BR. Downregulation with CRISPR Cas9 or blockade of the CCK-BR with an antagonist decreases growth in vitro and proglumide therapy decreases tumor growth in vivo. Strategies that block signaling at the CCK-BR maybe a novel therapeutic option for HCC treatment.
Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation (2018)

Australia New Zealand Clinical Trial Registry. www.anzctr.org.au Registration: ACTRN12605000042640 , Date: 26th July 2005. Retrospectively registered, trial commenced prior to registry availability.
Optical Control of Small Molecule-Induced Protein Degradation (2019)

As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discreet spatiotemporal control over its activity, we have developed a broadly applicable approach for the optical control of small molecule-induced protein degradation. Installation of photolabile caging groups onto ligands recruiting Von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases enabled optical control over protein degradation.
Identification of a new phase in the Ai-C-B ternary by high-resolution transmission electron microscopy (1987)

The purpose of this note is to report the identification of a ternary (XI) phase which has been observed as a reaction product during the processing of B 4 C-Al composites. These ceramic-metal composites (cermets) have the unique potential for structural applications because of their low density (&gt; 2.6 g/cc) and a desirable combination of mechanical properties. Guidelines for the processing of B 4 C-Al have been successfully established; and now it is possible to produce tailored microstructures with varying amounts of constituent phases. The samples for the analysis were prepared by the following procedure. First, it was necessary to heat the B 4 C powder compacts in excess of 2000°C to attain an interconnected B 4 C skeletal structure. Liquid aluminum was then infiltrated into this B 4 C network at 1170°C.
Abstract 15717: Acute On/Off Effects of Baroreceptor Activation Therapy (BAT) on Blood Pressure After Long-Term Therapy for Resistant Hypertension: Single-Center Experience With the Barostim Neo System (2013)

Background: Nonpharmacologic therapies have recently become available that can lower blood pressure (BP) when medical therapy is not sufficient. Chronic baroreceptor activation therapy (BAT) has been shown to reduce BP for at least 6 months using the Barostim neo system, which allows unilateral stimulation with a minimally invasive implantation. However, it is not known whether long-term chronic baroreceptor stimulation influences the acute responsiveness to stimulation. Therefore we determined the on/off effects of BAT at different time points after implantation.

Methods: Resistant HTN patients (n=12) were enrolled in an open-label, single-arm evaluation of Barostim neo after exclusion of secondary hypertension. Initial eligibility criteria for barostim implantation were systolic BP ≥ 140mmHg despite stable (≥ 4 weeks) medical therapy consisting of ≥ 3 antihypertensive drugs including at least one diuretic. For on/off testing three BP measurements were performed between 1 and 25 months after activation (mean 13.6 months): after 5 min rest with activated device, 5 min after deactivation of the device and 5 min after reactivation of the device.

Results: Before BAT mean office cuff BP was 178.2 ± 26.6 mmHg (systolic BP; SBP) over 99.2 ± 19.0 mmHg (diastolic BP; DBP). At the time of on/off testing BP was reduced to 148.8 ± 26.5 mmHg (SBP; p=0.01) over 87.8 ± 20.3 mmHg (DBP; p=0.09).

On deactivation of the device BP increased by 11.3 ± 15.6 mmHg (systolic BP; p=0.03) and 6.3 ± 11.8 mmHg (diastolic BP; p=0.09) and decreased after reactivation by 15.3 ± 18.0 mmHg (SBP; p=0.01) and 8.1 ± 10.8 mmHg (DBP; p=0.03). There was no correlation between duration of chronic BAT and systolic or diastolic on/off response (all p>0.1).

Conclusions: After 13.6 months of follow-up, unilateral baroreceptor activation therapy (BAT) reduces BP consistently in patients with resistant HTN. The acute on/off response to BAT is the same in patients after long-term treatment as in those with recent device activation. Thus, no evidence of tolerance over time to chronic BAT can be found, indicating that this therapy is fully effective in the long-term treatment of patients with resistant HTN.
UbiquiTouch (2020)

We present UbiquiTouch, an ultra low power wireless touch interface. With an average power consumption of 30.91μW, UbiquiTouch can run on energy harvested from ambient light. It achieves this performance through low power touch sensing and passive communication to a nearby smartphone using ambient FM backscatter. This approach allows UbiquiTouch to be deployed in mobile situations both in indoor and outdoor locations, without the need for any additional infrastructure for operation. To demonstrate the potential of this technology, we evaluate it in several different and realistic scenarios. Finally, we address the future application space for this technology.
Patterns of lingual tissue deformation associated with bolus containment and propulsion during deglutition as determined by echo‐planar MRI (1998)

Disordered lingual function is a common clinical attribute of patients with oropharyngeal dysphagia. To determine physiologic patterns of lingual tissue motion during swallowing, we imaged the actively deforming tongue during water bolus swallows with sequential single-slice sagittal orientation echo-planar imaging. At rest, with the bolus contained in the oral cavity before swallow initiation, the tongue displayed a characteristic curved configuration consisting of a convex surface (anterior to the bolus) in continuity with a concave surface (containing the bolus) and a posterior-located convex surface (comprising the tongue base). With swallow initiation, the previously deformed tongue underwent rapid biphasic displacement: (a) superior displacement of the anterior tongue and deepening of the midposterior-located bolus-containing concavity, resulting in a laterally beveled surface encompassing the bolus; and (b) retrograde displacement of the configured tissue, resulting in clearance of the bolus from the oral cavity to the oropharynx. These findings indicate that deglutitive tongue action can be depicted by echo-planar imaging as a series of deformative surface modifications, which are related to the activity of intrinsic and extrinsic lingual muscles.
Vis-à-vis: A Visual Language for Spreadsheet Visualizations (2011)

Finding ways for information workers to easily create and modify visualizations that display their own data has been a long time goal within the visualization community. We describe Vis-a-vis, a declarative language for defining and extending visu-alizations directly within spreadsheets. Vis-a-vis allows users to directly bind data and formula to the visual attributes of an extensible set of visualization primitives. The visualizations that Vis-a-vis creates can be shared and modified easily, allowing users to modify existing visualizations. This approach allows users to select visualizations from a gallery, to customize them easily, or to create novel visualizations. The approach leverages familiar formulas and data from spreadsheets. We prototype a system that uses this language, and use it to build a number of standard and custom visualizations, and gather formative feedback from a small user study.
Polynuclear Olefin Polymerization Catalysis: Proximity and Cocatalyst Effects Lead to Significantly Increased Polyethylene Molecular Weight and Comonomer Enchainment Levels (2004)

Bei der Ethen-Polymerisation wird ein 70-mal höheres Molekulargewicht erreicht, wenn C1-Zr2 anstelle von (CH2)2-verbrücktem C2-Zr2 eingesetzt wird (siehe Schema). Mit C2-Zr2Cl4 oder C1-Zr2Cl4 und MAO-Cokatalysator erhält man ein 600-mal höheres Polyethylen(PE)-Molekulargewicht als mit ZrCl2. Dies stützt die These, dass eine Nachbarschaft zweier Zr-Zentren die Kettenübertragungsgeschwindigkeit beeinflusst und dieser Effekt stark vom Cokatalysator abhängt. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z460288_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages (2023)

<i>N</i> -acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) is a zinc metallohydrolase that hydrolyzes <i>N</i> -acyl-phosphatidylethanolamine (NAPEs) to form <i>N</i> -acyl-ethanolamides (NAEs) and phosphatidic acid. Several lines of evidence suggest that reduced NAPE-PLD activity could contribute to cardiometabolic diseases. For instance, <i>NAPEPLD</i> expression is reduced in human coronary arteries with unstable atherosclerotic lesions, defective efferocytosis is implicated in the enlargement of necrotic cores of these lesions, and NAPE-PLD products such as palmitoylethanolamide and oleoylethanolamide have been shown to enhance efferocytosis. Thus, enzyme activation mediated by a small molecule may serve as a therapeutic treatment for cardiometabolic diseases. As a proof-of-concept study, we sought to identify small molecule activators of NAPE-PLD. High-throughput screening followed by hit validation and primary lead optimization studies identified a series of benzothiazole phenylsulfonyl-piperidine carboxamides that variably increased activity of both mouse and human NAPE-PLD. From this set of small molecules, two NAPE-PLD activators (VU534 and VU533) were shown to increase efferocytosis by bone-marrow derived macrophages isolated from wild-type mice, while efferocytosis was significantly reduced in <i>Napepld</i> <sup><i>-/-</i></sup> BMDM or after Nape-pld inhibition. Together these studies demonstrate an essential role for NAPE-PLD in the regulation of efferocytosis and the potential value of NAPE-PLD activators as a strategy to treat cardiometabolic diseases.
ChemInform Abstract: Synthesis and Analysis of 506BD, a High‐Affinity Ligand for the Immunophilin FKBP. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Safe Handling and Disposal of Nanostructured Materials (2015)

Abstract Applications based on nanostructured materials have been increasing, not only in sectors such as medicine and electronics, but also in the oil and gas industry. Nanostructured materials are substances that contain at least one dimension in the nanometer-size regime, and can include nanoparticulate materials such as quantum dots, nanofibrous materials such as carbon nanotubes, and nanoporous material such as activated carbon. In addition, nanomaterials can be as-received/produced or subsequently functionalized with a wide range of chemical species. Further, distinctions must be drawn between naturally occurring and/or biodegradable nanostructured materials and synthetic nanomaterials. The latter need more scrutiny, because they may not be in equilibrium with their environment. For example, non-biodegradable nanomaterials could accumulate in the tissues and organs of human beings, animals, and plant/trees with unknown long-term consequences. Although use of nanomaterials in the oil and gas industry is still not widespread, potential applications of these novel materials include: waste water treatment, antimicrobial additives, multifunctional coatings, etc. These applications cause concerns regarding their safe handling and disposal, whether in the downhole environment or at the surface. In this paper we provide a first-hand perspective about the appropriate handling of nanomaterials in a laboratory setting, coupled with a review of the related literature currently available. Such a perspective helps define guidelines for the safe implementation of nanomaterial-related technologies in the downhole setting, because the day is not far off when the industry will use these new materials extensively in the oilfield. In general, existing good laboratory practices apply and can serve as a foundation for developing methods to handle nanomaterials with enhanced safety features. Personal protective equipment and deliberate, planned actions need to be combined with some specific control measures to ensure safety. Some of these measures include waste minimization, specialized containments, and the control of nanoparticulate aerosols. And finally, compliance is important in terms of evolving regulations in the nanomaterials arena. Nanosafety need not be an ambiguous concept as long as the personnel are well trained and informed about the properties of the materials they are handling. The experience shared in this paper can be applied to the safe handling and disposal of nanomaterials in general, and in any industrial, institutional, or academic setting.
Contralateral hearing loss following inner ear injury: sympathetic cochleolabyrinthitis? (1985)

Acoustic tumor surgery provided an ideal model in which to study possible contralateral hearing loss following a destructive surgical procedure on the inner ear. Follow-up audiometric studies were performed on patients with unilateral acoustic tumors who had undergone resection of their tumors. Patients who had obvious causes for contralateral hearing loss, such as chronic otitis media, unrelated otologic surgery, and noise-induced hearing loss, were excluded from this patient population. A total of 380 patients had available pre- and postoperative audiograms. A mean air-conduction threshold (500, 1000, 2000 Hz) of greater than or equal to 20 dB was considered a significant hearing loss. After adjusting these losses for presbycusis, 1.3% of these patients still had a significant contralateral hearing loss. We discuss the possible causes for the development of contralateral hearing loss and examine the possibility that, following surgical manipulation and injury to the inner ear, immunocompetent cells become sensitized to previously unseen inner ear antigens, setting the stage for contralateral inner ear dysfunction. The similarities of this condition to sympathetic ophthalmia are discussed.
Investigating Bidirectional Recurrent Neural Network Language Models for Speech Recognition (2017)

Investigating bidirectional recurrent neural network language models for speech recognition.
Physiological, biochemical, and metabolic responses of abiotic plant stress: salinity and drought (2021)

The most important types of abiotic stress that affect agricultural crops throughout the world are drought and salinity. These stresses will continue to worsen as the current climate crisis progresses. Plants have evolved a complex set of mechanisms in order to protect themselves from salt and drought. At the macrobiological level, these include alterations in growth rate, water balance, antioxidant defenses, and photosynthesis. Altered metabolites include proline, carbohydrates, glycine betaine, gamma-aminobutyric acid, and polyamines. It is not surprising, thus, that one of the most important research areas of plant biology is the study of plant responses to abiotic stress and stress tolerance mechanisms. The methods, used in this study, are diverse, including the study of physiological properties, biochemical research, and metabolomics approaches toward abiotic stress. This awareness should lead to the development of (near) future, sustainable and better-adapted agriculture in the sense of global warming and environmental emission scenarios. Also, different information presented in this overview can be regarded by the scientific community to produce tolerant cultivars in response to salinity and drought stresses.