gebhart/patrepeval huggingface dataset:
A Sensory and Chemical Analysis of Fresh Strawberries Over Harvest Dates and Seasons Reveals Factors That Affect Eating Quality (2008)

The aim of this study was to understand the flavor components of eating quality of several strawberry ( Fragaria × ananassa Duch.) genotypes grown in Florida over two harvest seasons. Five selections and one cultivar of the University of Florida Breeding program as well as two new cultivars from Australia (Rubygem and Sugarbaby) harvested on different dates from the same grower were evaluated by sensory evaluation. Festival, the main strawberry cultivar grown in Florida, had low ratings for flavor and sweetness in January and March. Selection FL 00-51 and ‘Rubygem’ had relatively high and consistent ratings for flavor and sweetness compared with the other selections. Genotypes with low flavor ratings were always judged as “not sweet enough” by the panelists, thus linking flavor to sweetness preference. Instrumental analysis confirmed that typically these selections had low soluble solids content (SSC) and/or high titratable acidity (TA), thus explaining their lack of sweetness. Volatile compounds that varied only quantitatively did not seem to influence the flavor rating except for ‘Sugarbaby’. This cultivar contained between seven and 40 times less total ester content than the other selections and was disliked by panelists despite its high sugar content and perceived sweetness. It was perceived as having an artificial peach- or blueberry-like flavor. A principal component analysis was performed with chemical parameters (SSC, TA, and volatile content) and selections over the two harvest seasons. Chemical composition was mainly influenced by harvest date, except for FL 00-51. This selection maintained high volatile content and SSC throughout the seasons, explaining consistently high flavor ratings.
Closed-Loop Artificial Pancreas Using Subcutaneous Glucose Sensing and Insulin Delivery and a Model Predictive Control Algorithm: Preliminary Studies in Padova and Montpellier (2009)

New effort has been made to develop closed-loop glucose control, using subcutaneous (SC) glucose sensing and continuous subcutaneous insulin infusion (CSII) from a pump, and a control algorithm. An approach based on a model predictive control (MPC) algorithm has been utilized during closed-loop control in type 1 diabetes patients. Here we describe the preliminary clinical experience with this approach. Six type 1 diabetes patients (three in each of two clinical investigation centers in Padova and Montpellier), using CSII, aged 36 +/- 8 and 48 +/- 6 years, duration of diabetes 12 +/- 8 and 29 +/- 4 years, hemoglobin A1c 7.4% +/- 0.1% and 7.3% +/- 0.3%, body mass index 23.2 +/- 0.3 and 28.4 +/- 2.2 kg/m(2), respectively, were studied on two occasions during 22 h overnight hospital admissions 2-4 weeks apart. A Freestyle Navigator(R) continuous glucose monitor and an OmniPod insulin pump were applied in each trial. Admission 1 used open-loop control, while admission 2 employed closed-loop control using our MPC algorithm. In Padova, two out of three subjects showed better performance with the closed-loop system compared to open loop. Altogether, mean overnight plasma glucose (PG) levels were 134 versus 111 mg/dl during open loop versus closed loop, respectively. The percentage of time spent at PG > 140 mg/dl was 45% versus 12%, while postbreakfast mean PG was 165 versus 156 mg/dl during open loop versus closed loop, respectively. Also, in Montpellier, two patients out of three showed a better glucose control during closed-loop trials. Avoidance of nocturnal hypoglycemic excursions was a clear benefit during algorithm-guided insulin delivery in all cases. This preliminary set of studies demonstrates that closed-loop control based entirely on SC glucose sensing and insulin delivery is feasible and can be applied to improve glucose control in patients with type 1 diabetes, although the algorithm needs to be further improved to achieve better glycemic control.
Targeted anti-BCR-ABL+ ALL therapy may benefit the heart (2021)

Abstract Targeted therapies are currently considered the best cost-benefit anti-cancer treatment. In hematological malignancies, however, relapse rates and non-hematopoietic side effects including cardiotoxicity remain high. We here describe significant heart damage due to advanced acute lymphoblastic leukemia with t(9;22) encoding the bcr-abl oncogene (BCR-ABL+ ALL) in murine xenotransplantation models. Echocardiography reveals severe cardiac dysfunction with impaired left ventricular function and reduced heart and cardiomyocyte dimensions associated with increased apoptosis. This cardiac damage is fully reversible, but cardiac recovery depends on the therapy used to induce ALL remission. Chemotherapy-free therapy with dasatinib and venetoclax (targeting the BCR-ABL oncoprotein and mitochondrial Bcl2, respectively), as well as dexamethasone can fully revert cardiac defects whereas depletion of otherwise identical ALL in a genetic model using HSV-TK cannot. Mechanistically, dexamethasone induces pro-apoptotic BIM expression and apoptosis in ALL cells but enhances pro-survival BCLXL expression in cardiomyocytes and clinical recovery with reversion of cardiac atrophy. These data demonstrate that therapies designed to optimize apoptosis induction in ALL may circumvent cardiac on-target side effects and may even activate cardiac recovery. In the future, combining careful clinical monitoring of cardiotoxicity in leukemic patients with further characterization of organ-specific side effects and signaling pathways activated by malignancy and/or anti-tumor therapies seems reasonable.
Tutorial on DOT (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Pogue, "Tutorial on DOT," in Biomedical Optics, Technical Digest (CD) (Optica Publishing Group, 2006), paper MF1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Three-dimensional particle imaging by wavefront sensing (2006)

We present two methods for three-dimensional particle metrology from a single two-dimensional view. The techniques are based on wavefront sensing where the three-dimensional location of a particle is encoded into a single image plane. The first technique is based on multiplanar imaging, and the second produces three-dimensional location information via anamorphic distortion of the recorded images. Preliminary results show that an uncertainty of 8 microm in depth can be obtained for low-particle density over a thin plane, and an uncertainty of 30 microm for higher particle density over a 10 mm deep volume.
Imaging: PEGylated Luminescent Gold Nanoclusters: Synthesis, Characterization, Bioconjugation, and Application to One‐ and Two‐Photon Cellular Imaging (Part. Part. Syst. Charact. 5/2013) (2013)

Biocompatible, near-infrared luminescent gold nanoclusters (AuNCs) are synthesized directly in water using PEG-dithiolane ligands terminating in either a carboxyl, amine, azide or methoxy group as presented by Igor L. Medintz and co-workers on page 453. Following bioconjugation testing, stability assays, and extensive characterization of their one- and two-photon absorption cross-section and emission, the AuNCs are demonstrated in high signal-to-noise one- and two-photon cellular imaging with mini mal cytoxicity.
An Exploratory Study of Tag-based Visual Interfaces for Searching Folksonomies (2009)

Aesthetic features such as animation, 3D interaction, and visual metaphors are becoming commonplace in multimedia search interfaces. However, it is unclear which attributes are needed to encourage people to use these interfaces on an ongoing basis. To design a visual interface that will elicit continual use, we first need to establish a better understanding of users’ goals and strategies, in order to determine which features are critical to support those tasks. This paper reports on an exploratory study of individuals engaging with five different image and video search interfaces. Our study helped us to understand users’ experiences with a variety of features and design elements, as well as categorize their common search tasks and strategies. We identified four distinct types of search: Search Known Objects + Known Keywords, Search Known Objects + Unknown Keywords, Search Unknown Objects + Known Keywords, and Search Unknown Objects + Unknown Keywords. We also identified common strategies used to accomplish each of these search types. Our findings suggest that search interfaces should maximize screen space used for visual representations of the media, provide on-demand access to titles, tags, and other metadata, and provide contextual information about previously viewed items, current keywords, and alternate keyword possibilities.
Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations (2004)

As a result of this study, we recommend using only genes called 'present' in cross-platform correlations. However, as in this study, a large number of genes may be lost from the correlation due to differing levels of noise between platforms. This is an important consideration given the apparent difference in sensitivity of the two platforms. Data from microarray analysis need to be interpreted cautiously and therefore, we provide guidelines for making cross-platform correlations. In all, this study represents the most comprehensive and specifically designed comparison of short-oligonucleotide microarray platforms to date using the largest set of overlapping genes.
High breakdown voltage GaAs schottky diode for a high efficiency rectifier in microwave power transmission systems (2015)

Microwave wireless power transmission systems require a high RF-DC conversion efficiency rectifier at input power such as 1 W. To meet this requirement, a rectifying device with high breakdown voltage is developed. This paper describes a fabricated high breakdown voltage GaAs Schottky Barrier Diode (SBD) as the rectifying device. The fabricated GaAs SBD at low doping concentration of 2.6×1016 cm-3 achieves breakdown voltage of 23.5 V and the conversion efficiency of 77.2% at input power of 27 dBm under condition without harmonic tuning technique which is agreed with simulation result. When harmonic tuning technique is adopted, a 5.8 GHz-band singleshunt rectifier with the fabricated GaAs SBD achieves the conversion efficiency of 81.7% at input power of 27 dBm in simulation. This conversion efficiency is the best performance at around 1 W input power and C-band to our knowledge.
Cytokines reinstate NK cell–mediated cancer immunosurveillance (2014)

In healthy individuals, cells that lose expression of MHC class I molecules are quickly targeted for elimination by NK lymphocytes. A paradox in cancer immunology is the observation that many tumor cells often have a drastic reduction of MHC class I molecules, yet these cells are not eliminated by NK cells, as they should be. In this issue of the JCI, Ardolino et al. demonstrate that NK cells that infiltrate MHC class I-deficient tumors acquire an anergic state that can be reversed by particular combinations of exogenous cytokines. These results indicate that IL-12 plus IL-18 or a recombinant interleukin engineered to stimulate the IL-2 receptor β/γ heterodimer (but not the IL-2 receptor α/β/γ complex) have the potential to be used clinically to reinstate immunosurveillance against MHC class I-deficient tumors.
Dynamics of Si-H Vibrations in an Amorphous Environment (2000)

We present results of the first vibrational photon-echo, transient-grating, and temperature dependent transient-bleaching experiments on $a$-Si:H. Using these techniques, and the infrared light of a free electron laser, the vibrational population decay and phase relaxation of the Si-H stretching mode were investigated. Careful analysis of the data indicates that the vibrational energy relaxes directly into Si-H bending modes and Si phonons, with a distribution of rates determined by the amorphous host. Conversely, the pure dephasing appears to be single exponential, and can be modeled by dephasing via two-phonon interactions.
Early mobilization versus bed rest for incidental durotomy: an institutional cohort study (2022)

In this retrospective study, the rate of revision surgery was not higher in patients with durotomy who underwent immediate mobilization, and medical complications were significantly decreased. Flat bed rest > 24 hours following incidental durotomy was associated with increased length of stay and increased rate of medical complications. After primary repair of an incidental durotomy, flat bed rest may not be necessary and appears to be associated with higher costs and complications.
Pleiades Fractionated Space System Architecture and the Future of National Security Space (2008)

In recent years, national security space systems have been plagued by cost overruns, schedule slips, and requirements creep. Notable programs have received much coverage in the press after incurring multiple Nunn-McCurdy cost growth breaches (total program cost increase by greater than 25%) or being cancelled outright. While these programs are the most visible, they are merely examples of the widespread problems with the government’s and industry’s approach to military space. While a spacecraft that is never launched obviously provides a poor return on government investment, those spacecraft that have reached orbit may be equally bad investments if mission needs have changed or a critical component fails soon after launch. Recent studies suggest that fractionated space systems can produce a higher value return on investment than traditional monolithic systems. Rather than continuing to design large monolithic satellites with unrealizable and competing requirements for performance and lifetime, we plan to develop a fractionated space system architecture, informed by value-centric engineering, that enables rapid initial operational capability through staged deployment, flexibility to changing national security needs, and robustness against attack and failures. The Pleiades architecture implements fractionated space systems, where the system’s functionality is spread over multiple, heterogeneous spacecraft modules. Each spacecraft module is a free-flying entity that has its own set of typical spacecraft bus functions but carries a unique mission payload or a resource such as a mission data processor, solid state recorder or high bandwidth downlink. The spacecraft modules fly in a cluster, and communicate with each other through a shared wireless network. The Pleiades architecture allows for rapid response to operational needs, whether it be by launching new spacecraft modules to join a cluster or by retasking existing spacecraft resources. Modules carrying new payloads or resources are produced more quickly and at lower cost than traditional systems by using commercial space best practices, single string designs (system reliability is achieved through redundancy across spacecraft modules), and the benefits of economies of scale. This can lower the barrier to deploying space-based assets for agencies that cannot currently afford them. Also, the cluster is less vulnerable to attack, and can disperse itself when there is an incoming threat. When a failure does happen, the architecture provides for a smooth degradation in capability until a replacement can be launched and brought in to the cluster. The fundamental innovation of this architecture is that information integration, not physical decomposition, is the key to realizing fractionation. In current space systems, the main inhibitor to rapid evolution and adaptation is stovepiped architectures that inhibit movement of information between elements, including the ground, and prevent reconfiguration of information flow to meet evolving mission needs. A fractionated space
Growth and fatty acid profiles ofHalophytophthoravesiculaandSalispinaspinosafrom Philippine mangrove leaves (2019)

Studies on marine-sourced fatty acids have gathered significant interest recently as an important component of aquaculture feeds and of biofuel production. Of the organisms capable of producing fatty acids, marine oomycetes are promising model organisms. One group of marine oomycetes are the Halophytophthora spp. which is known to have an important role in leaf decomposition, thereby changing the plant debris into exudates which are usable to consumers in the mangrove ecosystems. This study reports the three mangrove oomycetes isolated from Philippine mangrove forests, identified herein as Halophytophthora vesicula AK1YB2 (Aklan), H. vesicula PQ1YB3 (Quezon) and Salispina spinosa ST1YB3 (Davao del Norte). These isolates were subjected to growth analyses using varying incubation parameters (salinity level and pH), and for fatty acid production. Results revealed the presence of different fatty acids such as Arachidonic acid, Linoleic acid and Vaccenic acid when grown on V8S and PYGS media. This study is the first observation of fatty acids from S. spinosa and H. vesicula from the Philippines. SIGNIFICANCE AND IMPACT OF THE STUDY: Tropical Philippines straddling west of the Pacific Ocean and East of South China Sea is rich in marine and estuarine oomycetes. These micro-organisms, hitherto poorly known and unstudied in the country, play an important role in the nutritive cycle of the mangrove ecosystem. Due to the increasing demand for an alternative source of fatty acids, species of Oomycetes isolated from select mangrove forests in Luzon, Visayas and Mindanao were analysed for their fatty acid contents. Prospects for industrially-important fatty acids make these Oomycetes all-important to study in applied microbiology in the Philippine setting where these structurally simple micro-organisms abound.
User centric scheduling in cooperative networks (2010)

Future cellular networks have an increased demand on the capacity to handle. It is well known that intra and inter cell interference is the main challenge to increase the SIRs in cellular networks. Cooperative multi point transmission (CoMP) can avoid inter cell interference, but needs also a big amount of capacity on the backhaul. Partial CoMP (pCoMP) addresses this limitation and reduces the cooperation overhead which makes bigger cooperation areas possible. Simulations indicate gains similar to scenarios using a full user centric assignment. These assignments have normally very low penetration rates, but pCoMP can serve more than 90% of all users. This article explains the concepts of pCoMP and its capabilities regarding load balancing and resource scheduling preserving low complexity. pCoMP causes only a small amount of backhaul traffic which makes it possible to be used as a cost efficient solution to increase the spectral efficiency.
Emerging clinical phenotype of bone metastatic urothelial cancer (mUC): Association of early osseous metastases (EOM) and outcomes. (2020)

e17007 Background: Outcomes of patients (pts) with mUC with EOM have not thoroughly been described in the age of immuno-oncology. We hypothesized that EOM is associated with worse outcomes when compared to pts with non-osseous metastases (NOM). Methods: We used a multi-institutional database of pts with mUC who received systemic treatment (trt) between March 2005 and August 2019, to assess survival and palliative outcomes of pts with EOM vs NOM at the time of metastatic diagnosis (met dx). Wilcoxon rank-sum and chi-square tests were performed. Survival was estimated by Kaplan-Meier method, Cox regression analysis was performed. Results: We identified 270 pts, 72% men, mean age 67 ± 11 years, 28% never smokers. At met dx, 27% (n = 72) had ≥ 1 EOM; these pts were more likely to have de novo metastases vs. those with recurrent metastases (42% vs 19%, p &lt; 0.001). Pts with EOM were more likely to have a change or stop in 1st line trt due to clinical progression (30.6% vs 15.7%, p = 0.006), and received fewer total lines of systemic trt, median of 1.0 (1.0-5.0) vs. 2.0 (1.0-8.0), p = 0.05. Pts with EOM had shorter median overall survival (OS) vs. those with NOM, (6.1 vs 13.7 months, p &lt; .0001), HR = 2.79 (95% CI:1.95-3.97, p &lt; .0001). Median OS was shorter for pts with EOM who received 1 st line immune checkpoint inhibitor (n = 14) vs platinum-based chemotherapy (n = 43), (1.6 vs 9.1 months, p = 0.003). Pts with EOM received higher opioid analgesic doses at the first and last oncology outpatient visits compared to pts with NOM with mean morphine milligram equivalent (MME) dose of 60 ± 91 vs 28 ± 65 at first visit, p = 0.004, and 171 ± 214 vs. 94 ± 229 at last visit, p &lt; 0.001. Conclusions: The presence of EOM in mUC is associated with worse outcomes vs. pts with NOM. Pts with EOM may benefit from 1 st line platinum-based chemotherapy vs. checkpoint immunotherapy. Furthermore, pts with EOM experience more pain than pts with NOM and may benefit from early engagement with palliative care. Pts with EOM represent a population with a highly unmet need for systemic, targeted and/or radiation interventions. Molecular subtypes may further define these pts and analysis is planned. We encourage ongoing clinical trials to report outcomes in pts with EOM. A consensus on reporting of non-measurable disease is also needed. [Table: see text]
New time-domain conditioning circuit for resistive sensor: Behavioral modelling for simulation and optimization (2017)

This paper presents the behavioral modelling of a time domain signal conditioning circuit for resistive sensor. The architecture of the proposed circuit is based on a highly linear voltage-to-time converter circuit using injection locked oscillators as delay generators. A behavioral modelling based design approach is also presented in this paper. It facilitates the design in terms of time and complexity. Finally, the circuit is implemented using partially depleted silicon on insulator technology. Results show the accuracy of the conditioning circuit behavioral model and the utility of the adopted design approach.
Camp Butner Live-Site UXO Classification Using Hierarchical Clustering and Gaussian Mixture Modeling (2014)

We demonstrate in detail a semisupervised scheme to classify unexploded ordnance (UXO) by using as an example the data collected with a time-domain electromagnetic towed array detection system during a live-site blind test conducted at the former Camp Butner in North Carolina, USA. The model that we use to characterize targets and generate discrimination features relies on a solution of the inverse UXO problem using the orthonormalized volume magnetic source model. Unlike other classification techniques, which often rely on library matching or expert knowledge, our combined clustering/Gaussian-mixture-model approach first uses the inherent properties of the data in feature space to build a custom training list that is then used to score all unknown targets by assigning them a likelihood of being UXO. The ground truth for the most likely candidates is then requested and used to correct the model parameters and reassign the scores. The process is repeated several times until the desired statistical margin is reached, at which point a final dig is produced. Our method could decrease intervention by human experts and, as the results of the blind test show, identify all targets of interest correctly while minimizing false-alarm counts.