gebhart/patrepeval huggingface dataset:
A radiogallium-DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for imaging tumors (2011)

1536 Objectives Since expression of CXC chemokine receptor-4 (CXCR4) in tumors is closely related to tumor metastasis and growth, CXCR4 should be a potential target of nuclear imaging probes for evaluating the malignancy. In the present study, based on our previous finding that two functional moieties can be conjugated to radiogallium-DOTA chelate without reducing the complex stability, we designed and synthesized a two CXCR4 antagonist peptides (Ac-TZ14011)-conjugated Ga-DOTA chelate, Ga-DOTA-TZ2. This bivalent derivative was evaluated in vitro as a CXCR4 ligand for nuclear imaging in comparison with monovalent ligand, Ga-DOTA-TZ1. Methods Coupling of DOTA-bis(tert-butyl)ester with Ac-TZ14011, followed by deprotection, afforded DOTA-TZ2. After coordination with nonradioactive Ga3+, the affinity to CXCR4 was evaluated by competitive binding assay with 125I-SDF-1α. 67Ga-labeling was carried out by the reaction of DOTA-TZ2 with 67GaCl3 at 95°C for 30 min. In vitro cellular uptake of 67Ga-DOTA-TZ2 was investigated using CXCR4-overexpressing CHO cells and control CHO cells. Results In competitive binding assays, the IC50 values for Ga-DOTA-TZ2 and Ga-DOTA-TZ1 were 0.27 and 45 nM, respectively, suggesting a multivalent effect for CXCR4 binding. 67Ga-DOTA-TZ2 was synthesized in about 60% radiochemical yield and >99% radiochemical purity. In cellular uptake studies, 67Ga-DOTA-TZ2 exhibited a higher accumulation in CXCR4-expressing cells than control cells. The accumulation of 67Ga-DOTA-TZ2 in CXCR4-expressing cells was significantly higher than that of 67Ga-DOTA-TZ1. Furthermore, a dose-dependent inhibition was observed by addition of Ac-TZ14011, indicating CXCR4-mediated cellular uptake. Conclusions The newly developed radiogallium-DOTA-TZ2 would become a potential sensitive probe for nuclear imaging of CXCR4 in tumors
Panel discussion: Distributed intelligence in IoT (2016)

A record of the panel discussion was not made available for publication as part of the conference proceedings.
Supplementary Figure 7 from TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;PDF file - 24K, Effect of JAK kinase inhibitors with varying TYK2-specificity on growth and viability of T-ALL cells.&lt;/p&gt;
Characterization of proopiomelanocortin transcripts in human nonpituitary tissues. (1987)

Proopiomelanocortin (POMC), the precursor to adrenocorticotropic hormone and other related peptides, was originally identified in the corticotropic cell. Recent evidence shows that POMC products are also normally present in a variety of nonpituitary tissues. To investigate this phenomenon in humans we looked for the presence and characteristics of POMC transcripts in various adult tissues. Blot hybridization analysis of normal adrenal, thymus, and testis RNAs revealed a small RNA species approximately 400 nucleotides shorter than the 1200-nucleotide pituitary species. Primer extension and S1 nuclease mapping studies showed that this small RNA lacked exon 1 and exon 2 of the gene, and it corresponded to a set of at least six molecules starting 41 to 162 nucleotides downstream from the 5' end of exon 3. These RNAs appear to result from heterogeneous transcription initiation sites presumably under the control of "GC box" promoter sequences located in the 3' end of intron 2. They cannot encode a complete POMC molecule, and the only truncated POMC molecules that could be translated would lack a signal peptide necessary for membrane translocation and precursor processing. The use of highly sensitive S1 nuclease mapping techniques with uniformly labeled single-stranded DNA probes allowed the detection of a small but definite amount of the "normal," 1200-nucleotide, mRNA species. It is suggested that it is this POMC mRNA that is responsible for the local production of all the POMC peptides.
Syntheses of polystyrene–covalently bonded metalloporphyrin complexes and their reaction with molecular oxygen (1977)

Abstract The copolymer of styrene with protoporphyrin IX styrylamide, prepared by the reaction between the porphyrin di(acid chloride) and p ‐aminostyrene, was synthesized by radical copolymerization and characterized. The metal complexes of the copolymer were prepared by incorporating corresponding metal ions. It was found by electron spin resonance measurements that the cobalt(II) complex is able to absorb molecular oxygen reversibly in toluene at low temperature.
BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors (2019)

Bromodomain-containing protein 9 (BRD9) is a recently identified subunit of SWI/SNF(BAF) chromatin remodeling complexes, yet its function is poorly understood. Here, using a genome-wide CRISPR-Cas9 screen, we show that BRD9 is a specific vulnerability in pediatric malignant rhabdoid tumors (RTs), which are driven by inactivation of the SMARCB1 subunit of SWI/SNF. We find that BRD9 exists in a unique SWI/SNF sub-complex that lacks SMARCB1, which has been considered a core subunit. While SMARCB1-containing SWI/SNF complexes are bound preferentially at enhancers, we show that BRD9-containing complexes exist at both promoters and enhancers. Mechanistically, we show that SMARCB1 loss causes increased BRD9 incorporation into SWI/SNF thus providing insight into BRD9 vulnerability in RTs. Underlying the dependency, while its bromodomain is dispensable, the DUF3512 domain of BRD9 is essential for SWI/SNF integrity in the absence of SMARCB1. Collectively, our results reveal a BRD9-containing SWI/SNF subcomplex is required for the survival of SMARCB1-mutant RTs.
Versatile Framework for Power Delivery Exploration (2018)

Over the past decades, aggressive voltage scaling combined with increased power demands has placed stringent requirements on on-chip power quality. Unwanted voltage fluctuations and droops may cause a variety of issues, ranging from glitch power to device malfunction. If revealed at the later stages of the design process, mitigation techniques may become unbearably costly in both time and money. A framework for exploratory power delivery optimization is described to enhance the power delivery network during early stages of the design process in accordance with design specifications. The power delivery design process is converted into a constrained minimization problem, consisting of design metrics combined into objective and constraint functions. The framework supports the optimization of the power network characteristics while considering external, non-electrical design specifications, such as cost and area, providing a comprehensive network analysis capability. In one case study, a 15% reduction in decoupling capacitor placement along with a 38.6% reduction in power consumption is achieved while satisfying performance and power quality constraints.
Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5) (2012)

Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically determined hyperinflammatory syndrome caused by uncontrolled immune response mediated by T-lymphocytes, natural killer (NK) cells, and macrophages. STXBP2 mutations have recently been associated with FHL5. To better characterize the genetic and clinical spectrum of FHL5, we analyzed a cohort of 185 patients with suspected FHL for mutations in STXBP2. We detected biallelic mutations in 37 patients from 28 families of various ethnic origins. Missense mutations and mutations affecting 1 of the exon 15 splice sites were the predominant changes detectable in this cohort. Patients with exon 15 splice-site mutations (n = 13) developed clinical manifestations significantly later than patients with other mutations (median age, 4.1 year vs 2 months) and showed less severe impairment of degranulation and cytotoxic function of NK cells and CTLs. Patients with FHL5 showed several atypical features, including sensorineural hearing deficit, abnormal bleeding, and, most frequently, severe diarrhea that was only present in early-onset disease. In conclusion, we report the largest cohort of patients with FHL5 so far, describe an extended disease spectrum, and demonstrate for the first time a clear genotype-phenotype correlation.
Investigation of ITS Coexistence on the Physical Layer (2013)

Future cars will become more and more connected and will be equipped with more than one link. A connected car setup will include cellular links, WiFi links, links for safety and others. In order for these systems to operate together, bottlenecks with respect to coexistence need to be resolved. In this paper the authors will provide architecture design tools so that a driver can still make a call while the passengers connect their tablet pc and the car’s safety link is guaranteed. The following coexistence bottlenecks between 802.11p and other standards need attention. The wideband noise resulting from another transmitter can result in a substantial amount of noise power in the received 802.11p channel bandwidth. Concurrent operation of the standards can also give rise to blocking of the receiver and multiple concurrent transmitters can cause receiver inter-modulation. Both two mechanisms can be improved by means of receiver front-end selectivity as will be discussed.
A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System (2018)

Cytolytic pore-forming toxins including alpha hemolysin (Hla) and bicomponent leukotoxins play an important role in the pathogenesis of <i>Staphylococcus aureus</i>. These toxins kill the polymorphonuclear phagocytes (PMNs), disrupt epithelial and endothelial barriers, and lyse erythrocytes to provide iron for bacterial growth. The expression of these toxins is regulated by the two-component sensing systems Sae and Agr. Here, we report that a point mutation (L18P) in SaeS, the histidine kinase sensor of the Sae system, renders the <i>S. aureus</i> Newman hemolytic activity fully independent of Hla and drastically increases the PMN lytic activity. Furthermore, this Hla-independent activity, unlike Hla itself, can lyse human erythrocytes. The Hla-independent activity towards human erythrocytes was also evident in USA300, however, under strict <i>agr</i> control. Gene knockout studies revealed that this Hla-independent Sae-regulated activity was entirely dependent on gamma hemolysin A subunit (HlgA). In contrast, hemolytic activity of Newman towards human erythrocytes from HlgAB resistant donors was completely dependent on <i>agr</i>. The culture supernatant from Newman <i>S. aureus</i> could be neutralized by antisera against two vaccine candidates based on LukS and LukF subunits of Panton-Valentine leukocidin but not by an anti-Hla neutralizing antibody. These findings display the complex involvement of Sae and Agr systems in regulating the virulence of <i>S. aureus</i> and have important implications for vaccine and immunotherapeutics development for <i>S. aureus</i> disease in humans.
Comparison of Limited Feedback Schemes for NOMA Transmission in mmWave Drone Networks (2018)

Introducing non-orthogonal multiple access (NOMA) transmission to an unmanned aerial vehicle (UAV) based communication network is a promising solution to enhance spectral efficiency. However, for realistic deployment of such a network, identifying a practical user feedback scheme for NOMA is essential. In this paper, considering two practical feedback schemes we introduce NOMA transmission to UAVs acting as aerial base stations (BS) to provide coverage at a large stadium. In particular, a UAV-BS generates directional beams, and multiple users are served simultaneously within the same beam employing NOMA transmission. Each user is considered to have a target rate based on its quality of service (QoS) requirements. In order to relieve the burden of tracking and feeding back full channel state information, we consider two limited feedback schemes as practical alternatives: 1) user distance, and 2) user angle with respect to beamforming direction under different user region geometries. Our evaluation results show that NOMA with limited feedback can provide better sum rates compared to its orthogonal counterpart. Further, based on the geometry of user region we identify that there is an optimal feedback scheme and user ordering criteria for NOMA transmission which can maximize sum rates.
The excited state structure of the nitrogen-vacancy center in diamond (2006)

Optical and microwave double resonance techniques are used to obtain the excited state structure of single nitrogen-vacancy centers in diamond. The excited state is an orbital doublet and it is shown that it can be split and associated transition strengths varied by external electric fields and by strain. A group theoretical model is developed. It gives a good account of the observations and contributes to an improved understanding of the electronic structure of the center. The findings are important for quantum information processing and other applications of the center.
Promise and Challenges of a Data-Driven Approach for Battery Lifetime Prognostics (2021)

Recent data-driven approaches have shown great potential in early prediction of battery cycle life by utilizing features from the discharge voltage curve. However, these studies caution that data-driven approaches must be combined with specific design of experiments in order to limit the range of aging conditions, since the expected life of Li-ion batteries is a complex function of various aging factors. In this work, we investigate the performance of the data-driven approach for battery lifetime prognostics with Li-ion batteries cycled under a variety of aging conditions, in order to determine when the data-driven approach can successfully be applied. Results show a correlation between the variance of the discharge capacity difference and the end-of-life for cells aged under a wide range of charge/discharge C-rates and operating temperatures. This holds despite the different conditions being used not only to cycle the batteries but also to obtain the features: the features are calculated directly from cycling data without separate slow characterization cycles at a controlled temperature. However, the correlation weakens considerably when the voltage data window for feature extraction is reduced, or when features from the charge voltage curve instead of discharge are used. As deep constant-current discharges rarely happen in practice, this imposes new challenges for applying this method in a realworld system.
Graphoepitaxy for Pattern Multiplication of Nanoparticle Monolayers (2014)

We compute the free energy minimizing structures of particle monolayers in the presence of enthalpic barriers of a finite height βV(ext) using classical density functional theory and Monte Carlo simulations. We show that a periodic square template with dimensions up to at least 10 times the particle diameter disrupts the formation of the entropically favored hexagonally close-packed 2D lattice in favor of a square lattice. The results illustrate how graphoepitaxy can successfully order nanoparticulate films into desired patterns many times smaller than those of the prepatterned template.
A compressed digital output CMOS image sensor with analog 2-D DCT processors and ADC/quantizer (2002)

Progress in CMOS-based image sensors is creating opportunities for a low-cost, low-power one-chip video camera with digitizing, signal processing and image compression. Such a smart camera head acquires compressed digital moving pictures directly into portable multimedia computers. Video encoders using a moving picture coding standard such as MPEG and H.26x are not always suitable for integration of image encoding on the image sensor, because of the complexity and the power dissipation. On-sensor image compression such as a CCD image sensor for lossless image compression and a CMOS image sensor with pixel-level interframe coding are reported. A one-chip digital camera with on-sensor video compression is shown in the block diagram. The chip contains a 128/spl times/128-pixel sensor, 8-channel parallel read-out circuits, an analog 2-dimensional discrete cosine transform (2D DCT) processor and a variable quantization-level ADC (ADC/Q).
<title>Laser direct write for release of SiO<formula><inf><roman>2</roman></inf></formula> MEMS and nano-scale devices</title> (2004)

We have developed a novel process for releasing MEMS and nano-scale devices formed in SiO<sub>2</sub> on a Si substrate. Current approaches for releasing MEMS made of SiO<sub>2</sub> use wet chemical etches (e.g. EDTA or KOH) or gas phase chemical etches such as xenon difluoride. These approaches are inherently messy and difficult to control. We have shown that it is possible to release patterned SiO<sub>2</sub> structures using a direct write laser assisted chemical etching technique. The developed process removes Si only from the immediate area leaving behind the SiO<sub>2</sub> device. The technique allows the surrounding larger area of the Si wafer to be conserved for use in packaging or integration with electronics. Further, as the release is accomplished in the gas phase, we see none of the problems of "stiction" associated with a liquid etch release process. In fact, we have found this method to be so gentle that we have been able to release devices made from SiO<sub>2</sub> films on the order of hundreds of nanometers.
Keynote Speech: Improving understanding of both short and long term effectiveness of remediation strategies using geophysical characterization and monitoring (2017)

PreviousNext No AccessInternational Conference on Engineering Geophysics, Al Ain, United Arab Emirates, 9-12 October 2017Keynote Speech: Improving understanding of both short and long term effectiveness of remediation strategies using geophysical characterization and monitoringAuthors: Lee SlaterJudy RobinsonPauline KessouriTim JohnsonFred Day-LewisDung NyugenCarole JohnsonNathan SmithLee SlaterRutgers University Newark, Newark, NJ, USA, Judy RobinsonRutgers University Newark, Newark, NJ, USA, Pauline KessouriRutgers University Newark, Newark, NJ, USA, Tim JohnsonPacific Northwest National Laboratory, Richland, WA, USA, Fred Day-LewisU.S. Geological Survey, Storrs, CT, USA, Dung NyugenCDM Smith, Denver, CO, USA, Carole JohnsonU.S. Geological Survey, Storrs, CT, USA, and Nathan SmithCDM Smith, Denver, CO, USAhttps://doi.org/10.1190/iceg2017-080 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract New environmental management strategies are needed to improve the stewardship of contaminants in the subsurface. Geophysical methods have the potential to provide valuable short-term information on the effectiveness of environmental remediation efforts based on emplacement of amendments in the subsurface. The effective delivery of such amendments to contaminant source zones is nontrivial. Long-term alterations of the physicochemical and biogeochemical properties of the subsurface resulting from amendment injections are also challenging to evaluate using in situ methods. This paper describes applications of electrical imaging and borehole magnetic susceptibility methods to assess both short-term and long-term subsurface alterations associated with delivery of amendments into contaminated sediments. Keywords: environmental, imaging, magneticsPermalink: https://doi.org/10.1190/iceg2017-080FiguresReferencesRelatedDetails International Conference on Engineering Geophysics, Al Ain, United Arab Emirates, 9-12 October 2017ISSN (online):2159-6832Copyright: 2017 Pages: 382 publication data© 2017 Published in electronic format with permission by Society of Exploration Geophysicists (SEG)Publisher:Society of Exploration Geophysicists HistoryPublished: 12 Oct 2017 CITATION INFORMATION Lee Slater, Judy Robinson, Pauline Kessouri, Tim Johnson, Fred Day-Lewis, Dung Nyugen, Carole Johnson, and Nathan Smith, (2017), "Keynote Speech: Improving understanding of both short and long term effectiveness of remediation strategies using geophysical characterization and monitoring," SEG Global Meeting Abstracts : 442-445. https://doi.org/10.1190/iceg2017-080 Plain-Language Summary KeywordsenvironmentalimagingmagneticsPDF DownloadLoading ...
Functional recovery after complete contusion injury to the spinal cord and transplantation of human neuroteratocarcinoma neurons in rats (2002)

These findings suggest that the transplantation of the hNT neurons may be an effective means of reestablishing electrical connectivity of the injured spinal cord.
Supplemental Table 1 from <i>HEXIM1</i> as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues (2023)

&lt;p&gt;290 genes that were modulated by MS417 in both NCI-H1299 and MiaPaCa-2 cells.&lt;/p&gt;
Choroidal neovascularisation in pathological myopia: an update in management (2005)

Choroidal neovascularisation (CNV) secondary to pathological myopia is an important cause of significant visual impairment in young and middle aged adults globally and is particularly prevalent in Asian populations. In the past few years, there have been rapid advancements in the different treatments for myopic CNV. The purpose of this perspective is to give an overview of the natural history of myopic CNV and the various treatment options including laser photocoagulation, photodynamic therapy, sub-macular surgery, and macular translocation surgery. Future directions in the management of myopic CNV are also discussed.
Room Temperature Activation of Aromatic CH Bonds by Non‐Classical Ruthenium Hydride Complexes Containing Carbene Ligands (2003)

Abstract Non‐classical ruthenium hydride complexes are promising lead structures for the CH bond activation and functionalization of aromatic compounds. In the present paper, the preparation and crystallographic characterisation of the first organometallic complexes bearing dihydrogen ligands and N ‐heterocyclic carbene ligands in the same coordination sphere are described. The mixed phosphine/carbene complex [(IMes)Ru(H) 2 (H 2 ) 2 (PCy 3 )] (IMes=1,3‐dimesityl‐1,3‐dihydro‐2 H ‐imidazol‐2‐ylidene; 3a ) shows a unique reactivity pattern in the inter‐ and intramolecular activation of CH bonds. In particular, complex 3a effects a rapid and remarkably selective intermolecular activation of sp 2 CH bonds in simple aromatic compounds at room temperature.
Advanced Computational Docking of Two Teleocidin Congeners to Cys2 Domain of Protein Kinase C.DELTA.. (1997)

We simulated the docking of two teleocidin congeners to the cys2 domain structure observed in the crystalline complex of protein kinase Cδ with phorbol-13-acetate. The most stable docking models were searched for two conformers of (-)-indolactam-V ((-)-IL-V), twist and sofa form, and for (-)-benzolactam-V ((-)-BL-V8) by using an automatic docking method, ADAM, which can cover all possible binding modes and conformations. The twist form of (-)-IL-V and (-)-BL-V8 molecules fitted well into the same cavity as phorbol-13-acetate. Of the three functional groups hydrogen-bonding to the protein, two hydrogen-bonded with protein atoms in common with phorbol-13-acetate, but the third one hydrogen-bonded with a different protein atom from that in the case of phorbol-13-acetate.