gebhart/patrepeval huggingface dataset:
Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults (2020)

SEEK and the European Commission Directorate-General for Research and Innovation, European Member States within the UNISEC (Universal Influenza Vaccines Secured) project.
Effect of Autotransfusion on Survival Outcomes in Patients Undergoing Liver Resection for Colorectal Liver Metastases (2020)

Perlmutter, Breanna MD; Elshamy, Mohammed MD; Tu, Chao MS; McMichael, John BSc; Aucejo, Federico MD; Quintini, Cristiano MD; Hyuck David Kwon, Choon MD, PhD; Simon, Robert MD; Walsh, Matthew R. MD, FACS; Augustin, Toms MD, MPH, FACS Author Information
A Markov chain approximation for the analysis of banyan networks (1991)

This paper analyzes the delay suffered by messages in a clocked, packet-switched, square Banyan network with k x k output-buffered switches by approximating the flow processes in the network with Markov chains. We recursively approximate the departure process of buffers of the nth stage in terms of thqt at the n -- lst stage. We show how to construct the transition matrix for the Markov chain at each stage of the network and how to solve for the stationary distribution of the delay in the queues of that stage. The analytical results are compared with simulation results for several cases. Finally, we give a method based on this approximation and the technique of coupling to compute upper bounds on the time for the system to approach steady state.
Adalimumab is effective for inducing clinical remission at week 4 regardless of baseline corticosteroid use (2011)

RESULTS: There were no significant differences in the rate of clinical remission at Week 4 following induction therapy nor in mean change from baseline in CDAI between patients receiving baseline corticosteroids vs. those who were not; one exception was observed at Week 4 which had a higher remission rate for the pooled 80/40 mg group in patients who were not receiving corticosteroids, p<0.05 (Table ). Clinical Remission Rates at Week 4: Patients With and Without Baseline Corticosteroid Use CONCLUSION: Baseline corticosteroids do not appear to influence the pattern of clinical remission nor changes in CDAI score from baseline after induction therapy with adalimumab.
Thermodynamic spiroketalization as an efficient method of stereochemical communication (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamic spiroketalization as an efficient method of stereochemical communicationNancy I. Totah and Stuart L. SchreiberCite this: J. Org. Chem. 1991, 56, 22, 6255–6256Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jo00022a003https://doi.org/10.1021/jo00022a003research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chained cross-training of assembly line workers (2004)

To function properly, assembly lines require the presence of every worker. When a worker is absent, management must scramble quickly to find a replacement. Cross-training workers to perform multiple tasks mitigates this difficulty. However, since cross-training is costly and limited by learning capacity and can confound the search for quality problems, it should be used judiciously. The present paper proposes a training strategy called chaining in which workers are trained to perform a second task, and the assignments of task types to workers are linked in a chain. It is shown that chaining is a practical and effective strategy for prioritizing cross-training to compensate for absenteeism on assembly lines.
Recombinant Marker Allergens: Diagnostic Gatekeepers for the Treatment of Allergy (2002)

During the past decade an increasing number of recombinant allergens have become available, representing a significant proportion of the epitope complexity of natural allergen extracts. Component-resolved diagnosis with recombinant allergens reveals the antibody reactivity profile of allergic patients and identifies the disease-eliciting allergen molecules. This article exemplifies how recombinant allergen molecules with high cross-reactive potential can be used as marker allergens to identify allergic patients who are cross-sensitized to a variety of allergen sources. It further demonstrates how the use of allergens with a restricted distribution in a certain group of allergen sources may allow the identification of patients who have been genuinely sensitized by a particular allergen molecule. Drawing from those examples, it is suggested how diagnostic tests based on such recombinant marker allergens may be used to improve the choice and monitoring of currently available forms of specific immunotherapy.
Improved Friction Reducer for Hydraulic Fracturing (2009)

Abstract An improved polyacrylamide friction reducer delivered in an inverse emulsion form has been developed for use in fresh water up to 2% KCl. The main benefits realized were an increased level of friction reduction along with an enhanced rate of inversion. These benefits were obtained without compromising the emulsion storage stability. These improvements were gained primarily by optimizing the breaker surfactant package used to release the polymer from its delivered form into the aqueous based treatment fluid. Friction reducers are often a significant portion of the aqueous based chemical stimulation package used in either the stimulation and/or completion of oil/gas wells. Common friction reducers used for fresh water operations typically have a decline in performance when exposed to aqueous based fluids of increased salt content. The performance decline is not solely due to the nature of the polymer, but rather the mechanism of polymer release from its inverse emulsion state. The presence of salt not only affects the polymer configuration but also the ability of the inverse emulsion to release the polymer from its water internal phase into the water continuous stimulation fluid. The new friction reducer was developed by examination of various surfactants by way of simple additions to ternary mixture designed experiments. A variety of bench top performance tests were used to narrow the selection yielding a final surfactant package. The final candidates were then screened using an in-house friction loop. The improved friction reducer dosed at 0.5gpt had a 29% increase in ultimate friction reduction in fresh water and a 119% increased performance in 2% KCl when compared to a standard friction reducer of similar charge and molecular weight. Ultimate performance enhancement was gained within reasonable raw material costs and stability limits. With the increased ultimate friction reduction and superior inversion rate, this new product will reduce the energy required to deliver a specific volume at a set rate or increase the rate of the delivered volume at the same power for water based systems containing up to 2% KCl for stimulations and/or completions.
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia (2015)

Defining features of chronic lymphocytic leukemia (CLL) are not only its immunophenotype of CD19(+)CD5(+)CD23(+)sIgdim expressing clonal mature B cells but also its highly variable clinical course. In recent years, advances in massively parallel sequencing technologies have led to rapid progress in our understanding of the CLL genome and epigenome. Overall, these studies have clearly demarcated not only the vast degree of genetic and epigenetic heterogeneity among individuals with CLL but also even within individual patient leukemias. We herein review the rapidly growing series of studies assessing the genetic and epigenetic features of CLL within clinically defined periods of its growth. These studies strongly suggest an evolving spectrum of lesions over time and that these features may have clinical impact.
Fairness and Diversity in Recommender Systems: A Survey (2023)

Recommender systems are effective tools for mitigating information overload and have seen extensive applications across various domains. However, the single focus on utility goals proves to be inadequate in addressing real-world concerns, leading to increasing attention to fairness-aware and diversity-aware recommender systems. While most existing studies explore fairness and diversity independently, we identify strong connections between these two domains. In this survey, we first discuss each of them individually and then dive into their connections. Additionally, motivated by the concepts of user-level and item-level fairness, we broaden the understanding of diversity to encompass not only the item level but also the user level. With this expanded perspective on user and item-level diversity, we re-interpret fairness studies from the viewpoint of diversity. This fresh perspective enhances our understanding of fairness-related work and paves the way for potential future research directions. Papers discussed in this survey along with public code links are available at https://github.com/YuyingZhao/Awesome-Fairness-and-Diversity-Papers-in-Recommender-Systems .
Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model (2022)

Our results indicate imidazole propionate as a new potentially relevant factor in relation to NASH and discuss the possible implication of gut microbiota dysbiosis in the development of NASH. In addition, the study emphasizes the need for considering the gut microbiota and its products when developing translational animal models for NASH.
Simulation of Occupant Response in Space Capsule Landing Configurations With Suit Hardware (2014)

The purpose of this study was to compare the response of the total human model for safety (THUMS) human body finite element model (FEM) to experimental postmortem human subject (PMHS) test results and evaluate possible injuries caused by suit ring elements. Experimental testing evaluated the PMHS response in frontal, rear, side, falling, and spinal impacts. The THUMS was seated in a rigid seat that mirrored the sled buck used in the experimental testing. The model was then fitted with experimental combinations of neck, shoulder, humerus and thigh rings with a five-point restraint system. Experimental seat acceleration data was used as the input for the simulations. The simulation results were analyzed and compared to PMHS measurements to evaluate the response of the THUMS in these loading conditions. The metrics selected to compare the THUMS simulation to PMHS tests were the chest acceleration, seat acceleration and belt forces with additional metrics implemented in THUMS. The chest acceleration of the simulations and the experimental data was closely matched except in the Z-axis (superior/inferior) loading scenarios based on signal analysis. The belt force data of the model better correlated to the experimental results in loading scenarios where the THUMS interacted primarily with the restraint system compared to load cases where the primary interaction was between the seat and the occupant (rear, spinal and lateral impacts). The simulation output demonstrated low injury metric values for the occupant in these loading conditions. In the experimental testing, rib fractures were recorded for the frontal and left lateral impact scenarios. Fractures were not seen in the simulations, most likely due to variations between the simulation and the PMHS initial configuration. The placement of the rings on the THUMS was optimal with symmetric placement about the centerline of the model. The experimental placement of the rings had more experimental variation. Even with this discrepancy, the THUMS can still be considered a valuable predictive tool for occupant injury because it can compare results across many simulations. The THUMS also has the ability to assess a wider variety of other injury information, compared to anthropomorphic test devices (ATDs), that can be used to compare simulation results.
Reporter Enzyme Inhibitor Study To Aid Assembly of Orthogonal Reporter Gene Assays (2013)

Reporter gene assays (RGAs) are commonly used to measure biological pathway modulation by small molecules. Understanding how such compounds interact with the reporter enzyme is critical to accurately interpret RGA results. To improve our understanding of reporter enzymes and to develop optimal RGA systems, we investigated eight reporter enzymes differing in brightness, emission spectrum, stability, and substrate requirements. These included common reporter enzymes such as firefly luciferase (Photinus pyralis), Renilla reniformis luciferase, and β-lactamase, as well as mutated forms of R. reniformis luciferase emitting either blue- or green-shifted luminescence, a red-light emitting form of Luciola cruciata firefly luciferase, a mutated form of Gaussia princeps luciferase, and a proprietary luciferase termed "NanoLuc" derived from the luminescent sea shrimp Oplophorus gracilirostris. To determine hit rates and structure-activity relationships, we screened a collection of 42,460 PubChem compounds at 10 μM using purified enzyme preparations. We then compared hit rates and chemotypes of actives for each enzyme. The hit rates ranged from <0.1% for β-lactamase to as high as 10% for mutated forms of Renilla luciferase. Related luciferases such as Renilla luciferase mutants showed high degrees of inhibitor overlap (40-70%), while unrelated luciferases such as firefly luciferases, Gaussia luciferase, and NanoLuc showed <10% overlap. Examination of representative inhibitors in cell-based assays revealed that inhibitor-based enzyme stabilization can lead to increases in bioluminescent signal for firefly luciferase, Renilla luciferase, and NanoLuc, with shorter half-life reporters showing increased activation responses. From this study we suggest strategies to improve the construction and interpretation of assays employing these reporter enzymes.
Atmospheric DBD plasma Deposition of ECO‐Friedly Release Liners for Pressure Sensitive Adhesive Tapes (2009)

Abstract The presented paper reports on the development of eco‐friendly non‐silicone containing release liners on plastic foils for pressure sensitive adhesive tapes. A solvent free process based on aerosol assisted dielectric barrier discharge (DBD) plasma deposition was used to obtain nano‐sized coatings. Various precursors have been investigated ranging from hydrocarbons and fluorinated hydrocarbons to (meth)acrylates and fluorinated (meth)acrylates. Best results were obtained using 2‐ethylhexyl acrylate. To improved the stability of release properties upon ageing, addition of photo initiators and acrylic cross‐linkers have been evaluated. Tape adhesion tests showed stable release values below 25 cN/20 mm for 2‐ethylhexyl acrylate plasma coatings with acrylic cross‐linkers. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
DCCP Extensions for Multipath Operation with Multiple Addresses (2019)

DCCP communication is currently restricted to a single path per
connection, yet multiple paths often exist between peers. The
simultaneous use of these multiple paths for a DCCP session could
improve resource usage within the network and, thus, improve user
experience through higher throughput and improved resilience to
network failure. Multipath DCCP provides the ability to
simultaneously use multiple paths between peers. This document
presents a set of extensions to traditional DCCP to support multipath
operation. The protocol offers the same type of service to
applications as DCCP and it provides the components necessary to
establish and use multiple DCCP flows across potentially disjoint
paths.
High Resolution Trapped Ion Mobility Spectrometery of Peptides (2014)

In the present work, we employ trapped ion mobility spectrometry (TIMS) for conformational analysis of several model peptides. The TIMS distributions are extensively compared to recent ion mobility spectrometry (IMS) studies reported in the literature. At a resolving power (R) exceeding 250, many new features, otherwise hidden by lower resolution IMS analyzers, are revealed. Though still principally limited by the plurality of conformational states, at present, TIMS offers R up to ∼3 to 8 times greater than modern drift tube or traveling wave IMS techniques, respectively. Unlike differential IMS, TIMS not only is able to resolve congested conformational features but also can be used to determine information about their relative size, via the ion-neutral collision cross section, offering a powerful new platform to probe the structure and dynamics of biochemical systems in the gas phase.
Charge emission induced transient leakage currents of a ‐Si:H and IGZO TFTs on flexible plastic substrates (2014)

The transient off‐state thermal emission leakage currents of hydrogenated amorphous silicon ( a ‐Si) and indium gallium zinc oxide (IGZO) metal oxide thin‐film transistors (TFTs) fabricated on flexible plastic substrates have been examined for the first time. The transient leakage currents resulting from the detrapping of charge in the TFT active layer were observed to decay in a 1/ t power law behaviour from 2 to 100 ms after switching the TFT test structures off. The results demonstrated a uniform density of states for both types of thin‐film devices and an ∼1.3× higher transient leakage current for the IGZO TFTs. It was also shown that the observed transient leakage currents result in a shot noise at the input to the data‐line charge integration amplifiers that is 20 × larger than predicted by using only the conventional static DC TFT leakage current measurements.
A Fragile Watermarking Scheme for Authentication of Semi-regular Meshes (2008)

This paper presents a fragile watermarking scheme for authentication of 3D semi-regular meshes. After one wavelet decomposition, the watermark is inserted by slightly modifying the norms and orientations of the obtained wavelet coefficient vectors. The inserted watermark is robust to the so-called content-preserving attacks including vertex reordering and similarity transformations. However, it is vulnerable to others attacks such as local and global geometric modifications and remeshing since the objective is to check the integrity of the mesh. Additionally, according to the watermark extraction result, these attacks can be precisely located on the surface of the attacked mesh in a blind way. Sufficient security level is also achieved by introducing secret keys and by using scalar Costa quantization scheme with appropriate parameter values. Experimental results demonstrate the efficacy of the proposed watermarking scheme.
The Gamma Variate with Random Shape Parameter and Some Applications (2010)

This letter provides a new outlook at the Gamma distribution and its involvement in the performance analysis of digital communications over wireless fading channels. Whereas the Gamma distribution is usually regarded as a two-parameter distribution with a scale and shape factors that are deterministic parameters, we investigate the implications and insight that can be drawn from considering a Gamma variate with a random shape factor. Applications of such a distribution in the context of information transmission over a wireless fading channel are provided and novel average symbol error probability (SEP) expressions for single and multi-channel reception are derived involving the Laplace transform of the new distribution. We analytically prove and verify via numerical simulations that the average SEP results induced by the random shape parameter are lower bounded by those obtained using a deterministic fading severity whose value equals the expected value of the random shape parameter.
Application Of Gradient-Index Lens Design Techniques To Lenses For Integrated Optics (1986)

Design problems associated with the design of Luneburg-type waveguide lenses fabricated by a waveguide index of refraction gradient are investigated. In particular, the control of polarization, modal, and chromatic aberration and focal length control are discussed. A design example of a lens to be fabricated by non-resist electron beam lithography which is corrected for polarziation aberration is presented.
<title>Image Reconstruction From Projections Using Circular Harmonic Expansion</title> (1980)

A method is described for image reconstruction which processes the projection data in polar rather than rectangular coordinates, and does not require backprojection. It is based on the decomposition of the object and its shadow (set of projections) into &quot;circular harmonics,&quot; or radial modulators of angular Fourier components. An inverse filter is derived which enables the radial modulators of the object to be reconstructed from those of the shadow. Experimental results from digital and coherent optical implementations are given. A real time optical reconstruction processor is proposed.
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption (2016)

VRC01 slightly delayed plasma viral rebound in the trial participants, as compared with historical controls, but it did not maintain viral suppression by week 8. In the small number of participants enrolled in these trials, no safety concerns were identified with passive immunization with a single bNAb (VRC01). (Funded by the National Institute of Allergy and Infectious Diseases and others; ACTG A5340 and NIH 15-I-0140 ClinicalTrials.gov numbers, NCT02463227 and NCT02471326 .).
Proportionate Frequency Domain Adaptive Algorithms for Blind Channel Identification (2006)

We present fast-converging adaptive blind channel identification algorithms for acoustic room impulse responses. These new algorithms exploit the fast-convergence of the improved proportionate normalized least-mean-square (IPNLMS) algorithm and address the problem of delay inherent in frequency domain algorithms by employing the multi-delay filter (MDF) structure. Simulation results for both speech and white Gaussian noise show that the proposed algorithms outperform current frequency domain blind channel estimation algorithms