gebhart/patrepeval huggingface dataset:
Deformable-Mirror Spatial Light Modulators (1990)

A brief overview of deformable-mirror spatial light modulator (SLM) technology is presented, followed by the first comprehensive review of the Texas Instruments deformable-mirror device (DMD), a subclass of deformable-mirror SLMs. The DMD architecture, fabrication, and operation (both analog and digital) are described. It is shown that amplitude-dominant or phase-dominant modulation is obtained by a simple modification of the pixel architecture. Representative DMD applications are presented.
Regression of Prostate Cancer Following Administration of Genistein Combined Polysaccharide (GCP™), a Nutritional Supplement: A Case Report (2002)

This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer.
Erratum: Scanning-tunneling-microscope-assisted assembling of hydrogen-saturated silicon clusters on Si(111)-(7×7) surfaces [Appl. Phys. Lett. 78, 3720 (2001)] (2004)

First Page
An accurate and transferable protocol for reproducible quantification of organic pollutants in human serum using direct isotope dilution mass spectrometry (2014)

A robust method has been developed for easy transfer between analytical laboratories to obtain highly accurate and reproducible quantification of persistent organic pollutants (POPs) in micro-volumes of serum. This method is suited for analysts researching the impact of environmental exposure on human health. When performed by highly trained analysts, existing methods can produce high quality data; however, complex sample preparation steps often cannot be consistently replicated by laboratories, leading to variance in extraction recovery and quantitation. By combining stir-bar sorptive extraction (SBSE) with direct isotope dilution (D-ID) mass spectrometry quantification, a new analytical method was developed. The D-ID quantification significantly improved accuracy, corrected sample-to-sample irreproducibility, and reduced sample preparation time. Independent production of statistically identical data then confirmed transfer of the validated operating protocol to an off-site laboratory with different instrument models. SBSE performance was compared with industry-accepted extraction techniques. D-ID quantification was compared with peer-reviewed relative isotopic response factor (RF) quantification methods. Holding other variables constant, D-ID improved accuracy by 250% and precision by 300% compared with RF; SBSE improved accuracy by 37% compared to industry-accepted extraction methods. Limits of quantification of the analytes ranged from 60 pg g(-1) to 1 μg g(-1). Protocol transfer exhibited <7% mean between-laboratory error and <2% mean within-laboratory RSD. These results indicate that a transferable method has been developed for academic, government, commercial, and clinical laboratories seeking to maximize throughput and improve quantitative validity. This validated method was applied in a recent clinical study to assess non-communicable disease in children in Pennsylvania, USA.
Integration of Bulk Acoustic Wave Filter in a Power-VCO for Mobile Communication System (2011)

International audience
A1adenosine receptor agonists and their potential therapeutic applications (2008)

The challenges associated with developing an A(1)-AdoR agonist for therapeutic intervention are now well defined in humans. Significant progress has been made in identifying agents for the treatment of atrial arrhythmias, T2D, and angina.
Supplementary Data from Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice (2023)

&lt;p&gt;Supplementary Figure 1: Construct design and expression. Supplementary Figure 2: Comparison of Native and SynCon FAP vaccines in C57Bl/6 mice. Supplementary Figure 3: Comparison of Native and SynCon FAP vaccines in Balb/c mice. Supplementary Figure 4: Efficacy of FAP vaccine in therapeutic prostate and breast tumor models. Supplementary Figure 5: Alteration of the tumor microenvironment using hyaluronidase is less effective at synergizing with DNA vaccines. Supplementary Figure 6: Immune responses from mice receiving combination mTERT + FAP vaccination. Supplementary Figure 7: Impact of SynCon FAP vaccine on immune cell subsets by flow cytometry. Supplementary Figure 8: FAP expression and immune cell infiltration in patients.&lt;/p&gt;
Instantaneous Interferometry: Another View (2010)

Single-camera frame instantaneous interferometry is an alternative optical test method where environmental noise prohibits conventional phase shifting methods. The flexibility and high performance of an optimized spatial carrier fringe method provides a compelling solution.
CONGENITAL HYPOTHYROIDISM: AGE AT START OF TREATMENT VERSUS OUTCOME (1983)

We studied 27 patients with congenital hypothyroidism by neurological and psychometric methods. 7 healthy siblings served as a control group for the psychometric evaluation. In 7 patients treatment had been started before the age of 1 month and in 10 patients after the age of 3 months. Our findings suggest that the progressive loss of intelligence potential starts from birth but if treatment is begun before the age of 1 month, then intelligence remains within normal range. The neurological damage seems to originate partly before birth, but more serious injuries arise if treatment is delayed beyond the age of 3 months.
REMOVAL OF MARROW T CELLS WITH OKT3-OKT11 MONOCLONAL ANTIBODIES AND COMPLEMENT TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE (1985)

We studied the feasibility of T cell depletion of bone marrow for transplantation in preventing acute graft-versus-host disease GVHD in patients having a high risk of acute GVHD. We report our preliminary clinical experience of the ex-vivo treatment of allogeneic marrow using a pan-T monoclonal antibody combination (OKT3-OKT11) plus baby rabbit complement. Ten patients received allografts from HLA-identical sibling donors. All patients had malignant hematological disease with poor prognosis (6 acute leukemia, 3 chronic granulocytic leukemia, and 1 multiple myeloma). Nine patients were at high risk of acute GVHD (older than 30 years for 4 patients, chronic granulocytic leukemia in acute or accelerated phase for 3, and acute leukemia in relapse for 2). Posttransplant management with methotrexate was maintained until day 100 in the first four patients and stopped at day 11 for the six others. The ex-vivo treatment with the OKT combination and complement removed 88.3% +/- 11.8 of the T lymphocytes. The myeloid progenitors recovered at the end of the procedure showed a moderate effect of monoclonal antibodies and complement (75.8% +/- 12.2). Engraftment was achieved in all patients: 23.3 days +/- 5.10 to reach 0.5 X 10(9) granulocytes per liter and 31.5 days +/- 12.2 to reach 50 X 10(9) platelets per liter. No acute GVHD was observed in this group of patients. Of the 10 patients, 7 are alive and well and have been in continuous remission from 2-10 months. Three patients have relapsed.
Abstract 5578: Quantitative kinase inhibitor profiling in native cell and tissue extracts (2010)

Abstract Protein kinases are currently the subject of intense pharmaceutical industry attention. An array of assays and tools have been developed to study their biological and structural properties, however despite these efforts, many questions remain regarding the nature and functional consequences of kinase regulatory events in vivo. We previously detailed a probe-based method for comprehensively probing the ATP binding sites of native protein kinases directly in cell or tissue lysates. Here we report several advances that dramatically increase the sensitivity, quantitative accuracy, and efficiency of this method. Using these improved methods, we determined the Kd values of ATP, Staurosporine and several clinically relevant kinase inhibitors against more than 200 protein and lipid kinases in two cell lines (HL60 and PC3). While the data supports many general trends and confirmed targets of the inhibitors identified through recombinant kinase assays, several striking differences were found. Detailed investigation of these differences reveal that native kinases can exhibit dramatically different behavior when compared to their recombinant counterparts. Overall these data provide an unprecedented picture of native kinase behavior and have profound implications for the development of kinase inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5578.
Mitochondrial Iron Sequestration in Dopamine‐Challenged Astroglia: Role of Heme Oxygenase‐1 and the Permeability Transition Pore (1999)

Little is currently known concerning the mechanisms responsible for the excessive deposition of redox-active iron in the substantia nigra of subjects with Parkinson's disease (PD). In the present study, we demonstrate that dopamine promotes the selective sequestration of non-transferrin-derived iron by the mitochondrial compartment of cultured rat astroglia and that the mechanism underlying this novel dopamine effect is oxidative in nature. We also provide evidence that up-regulation of the stress protein heme oxygenase-1 (HO-1) is both necessary and sufficient for mitochondrial iron trapping in dopamine-challenged astroglia. Finally, we show that opening of the mitochondrial transition pore (MTP) mediates the influx of non-transferrin-derived iron into mitochondria of dopamine-stimulated and HO-1-transfected astroglia. Our findings provide an explanation for the pathological iron sequestration, mitochondrial insufficiency, and amplification of oxidative injury reported in the brains of PD subjects. Pharmacological blockade of transition metal trapping by "stressed" astroglial mitochondria (e.g., using HO-1 inhibitors or modulators of the MTP) may afford effective neuroprotection in patients with PD and other neurological afflictions.
High-TcsuperconductorYBa2Cu3O7−δstudied by positron annihilation (1988)

We have measured the positron-lifetime and the Doppler-broadening spectra in the high-temperature superconductor $\mathrm{Y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ as a function of temperature between 77 and 295 K. Positron-lifetime and Doppler-broadening data show new features in the superconducting phase. These results are interpreted in terms of positron localization in lattice distortions and positron surface states.
The Evolution of Electronic Engine Diagnostics (1990)

&lt;div class="htmlview paragraph"&gt;Software systems on electronically controlled diesel truck engines typically provide diagnostic features to enable the engine mechanic to identify and debug system problems. As future systems become more sophisticated, so will the diagnostic requirements. The advantages of serviceability and accuracy found in todays electronic systems must not be allowed to degrade due to this increased sophistication. One method of maintaining a high level of serviceability and accuracy is to place an even greater priority on diagnostics and servicing in the initial design phase of the product than is done today. In particular, three major goals of future diagnostic systems should be separation of component failures from system failures, prognostication of failures and analysis of engine performance. This paper will discuss a system to realize these goals by dividing the diagnostic task into the Electronic System Diagnostics, Engine System Diagnostics and the Diagnostic Interface.&lt;/div&gt;
Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. (1987)

The amino acid sequence of the vitronectin receptor alpha subunit deduced from cDNA is presented. The sequence defines a 1047-amino-acid polypeptide precursor with a putative signal sequence, a large extracellular domain with several sites homologous to calcium binding sites in other proteins, a transmembrane domain, and a 32-amino-acid cytoplasmic domain. The 7-kilobase vitronectin receptor alpha subunit mRNA was found to be expressed in all cell lines examined, including endothelial cells, K562 and HEL leukemia cells, and osteosarcoma cells. In the two leukemia cell lines, the expression of the vitronectin receptor mRNA, as well as that of the fibronectin receptor, was enhanced in the presence of phorbol ester, a treatment known to increase the adhesiveness of these cells. The HEL cells were the only ones among the cell lines tested that also contained the mRNA of the platelet adhesion receptor alpha subunit, glycoprotein IIb. The expression of glycoprotein IIb was slightly enhanced by treatment of the cells with phorbol ester. These results complete the partial cDNA sequence of the vitronectin receptor alpha subunit published previously (Suzuki, S., Argraves, W. S., Pytela, R., Arai, H., Krusius, T., Pierschbacher, M. D., and Ruoslahti, E. (1986) Proc. Natl. Acad. Sci. U.S.A., 83, 8614-8618), confirm that the vitronectin receptor, and not IIb, is expressed in endothelial cells, and show that changes in the level of its expression correlate with changes in cell adhesiveness.
Towards Practical Software Stack Decoding of Polar Codes (2018)

The successive cancellation list decoding algorithm for polar codes yields near-optimal decoding performance at the cost of high implementation complexity. The successive cancellation stack algorithm has been shown to provide similar decoding performance at a much lower computational complexity, but software implementations report a sub-par T/P performance. In this technical report, the benefits of the fast simplified successive cancellation list decoder are extended to the stack algorithm, resulting in a throughput increase by two orders of magnitude over the traditional stack decoder.
Analysis of Coal by Static Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) (2010)

Coal remains a primary fuel for power generation. Herein we present time-of-flight secondary ion mass spectra (ToF-SIMS data) taken with a Ga primary ion beam from ca. 30 coal specimens. These commercially different coal specimens were obtained from coal mining companies and/or power plants. They represent all major coal types used in power generation (bituminous coals, subbituminous coals, and lignites), and include low-rank materials (lignites and subbituminous coals), which are represented as a minor portion of the data. Often, inorganic ions (Na+, Al+, Si+, and K+) are pronounced in the spectra, overshadowing peaks from organic moieties. This reflects the high sensitivity of SIMS under our analysis conditions for these inorganic species. These results, including a previous, published chemometrics analysis of this data (L. Pei, G. Jiang, B. J. Tyler, L. L. Baxter, and M. R. Linford, Energy &amp; Fuels 2008, 22, 1059), suggest that ToF-SIMS can be a useful method for coal analysis.
Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements (2012)

The p21(Cip1/WAF1) plays an important role in cell-cycle arrest. Here, we find that RNase L regulates p21-mediated G(1) growth arrest in AU-rich elements-dependent manner. We found a significant loss of p21 mRNA expression in RNASEL(-/-) MEFs and that the overexpression of RNase L in HeLa cells induces p21 mRNA expression. The p21 mRNA half-life significantly changes as a result of RNase L modulation, indicating a post-transcriptional effect. Indeed, we found that RNase L promotes tristetraprolin (TTP/ZFP36) mRNA decay. This activity was not seen with dimerization- and nuclease-deficient RNase L mutants. Deficiency in TTP led to increases in p21 mRNA and protein. With induced ablation of RNase L, TTP mRNA and protein expressions were higher, while p21 expression became reduced. We further establish that TTP, but not C124R TTP mutant, binds to, and accelerates the decay of p21 mRNA. The p21 mRNA half-life was prolonged in TTP(-/-) MEFs. The TTP regulation of p21 mRNA decay required functional AU-rich elements. Thus, we demonstrate a novel mechanism of regulating G(1) growth arrest by an RNase L-TTP-p21 axis.
Quantitative Structure‐Activity Relationships of Streptococcus pneumoniae MurD Transition State Analogue Inhibitors (2004)

Abstract Quantitative structure‐activity relationship (QSAR) studies on a set of Streptococcus pneumoniae MurD transition‐state inhibitors were performed, using a comprehensive set of molecular descriptors calculated by CODESSA software. Multiple and best multiple linear regressions were applied to generate models for predicting their inhibitory activity. The results (the best model had r 2 = 0.8818, s 2 = 0.0749, F = 87.04 and r $\rm{ {_{cv}^{2}}}$ =0.8488) demonstrate the importance of hydrogen bonding and that a matching conformation of ligands for interaction with the enzyme active site is required.
Optical characteristics of vertically aligned arrays of branched silver nanowires (2014)

Vertically aligned branched silver nanowires (Ag BNWs) were synthesized by electrodeposition. Typically, branched NWs seen in literature do not have vertical alignment of the branches, as opposed to the results shown here. A wavelength dependent absorption of these Ag BNWs was demonstrated in this work. The strong wavelength dependence of the reflectance and transmittance of these Ag BNWs may be attributed to the wave-guiding effect of the nanostructures.
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor (2002)

Sterol 27-hydroxylase (CYP27A1) is required for bile acid synthesis by both the classical and alternate pathways. Cyp27a1(-/-) mice exhibit a dramatic increase in the activity of cytochrome P450 3A (CYP3A), which catalyzes side-chain hydroxylations of bile acid intermediates, thereby facilitating their excretion in the bile and urine. We examine the role of the nuclear xenobiotic receptor PXR (pregnane X receptor) in this process. We demonstrate that expression of Cyp3a11 and other established PXR target genes is increased in the Cyp27a1(-/-) mice. WhenCyp27a1(-/-) mice are fed a diet containing either cholic acid or chenodeoxycholic acid, expression of CYP7A1, which catalyzes the rate-limiting step in bile acid biosynthesis, is strongly suppressed. In parallel, the induction of Cyp3a11 observed in these mice is reversed, suggesting that bile acid intermediates serve as PXR activators. In support of this hypothesis, three potentially toxic sterols (7alpha-hydroxy-4-cholesten-3-one, 5beta-cholestan-3alpha,7alpha,12alpha-triol, and 4-cholesten-3-one), including two that are known to accumulate in Cyp27a1(-/-) mice, are efficacious activators of mouse PXR. All three compounds are more potent activators of mouse PXR than of human PXR, which may explain in part why humans who lack functional CYP27A1 do not display a corresponding increase in CYP3A activity and are stricken with the disease cerebrotendinous xanthomatosis. Taken together, these results reveal the existence of a feedforward regulatory loop by which potentially toxic bile acid intermediates activate PXR and induce their own metabolism. In addition, this study demonstrates that animal models with alterations in gene expression can be used to identify endogenous ligands for orphan nuclear receptors.
Microdisk Design for Vertical Collection from Quantum Emitters (2021)

We report on progress to improve the free space coupling and Purcell enhancement of a diamond microdisk resonator using eigenfrequency modal analysis and robust topology optimization.
A General Chemistry Experiment to Predict and Measure Functional-Group Stretching Frequencies (2002)

An experiment suitable for first-year students is reported. In this activity, students use a molecular modeling program to compute infrared spectra for a series of molecules. From the data obtained, students generate a group frequency chart and use it to identify unknowns. This provides students with an introduction to vibrational spectroscopy and the use of molecular modeling.
Wavelength-division multiplexed optical interconnects using monolithic wavelength-graded VCSEL and resonant photodetector arrays (1999)

Monolithic wavelength-graded vertical-cavity surface- emitting laser (VCSEL) and wavelength-selective resonance enhanced photodetector (REPD) arrays have been developed for use in wavelength-division multiplexed optical interconnect architectures. The aim is to achieve a cost-effective wavelength-multiplexed optical interconnect that can carry a large amount of data over longer distances using a single optical fiber. A controllable means for producing wavelength-graded VCSEL and REPD arrays is described, based on the topography-controlled MOCVD growth on a patterned substrate. This technique allows the growth rate of all the epilayers to be scaled, thereby providing closer tracking of the reflectance peak and the gain peak and resulting in more uniform device characteristics. VCSELs and REPDs have been monolithically integrated using the same epilayer structure and the same growth technique. This paper focuses on (1) the characteristics of oxide-confined multi-wavelength VCSEL arrays, (2) the design and comparison of optimized REPD structures at 850 nm and at 980 nm, and (3) wavelength multiplexing and demultiplexing using VCSEL and REPD arrays.
Spectral degradation of Type II π-phase-shifted fiber Bragg gratings due to femtosecond laser induced loss (2019)

Narrowband high-temperature stable fiber Bragg gratings (FBGs) can be made by introducing a π-phase shift in the middle of a Type II periodic grating structure. This creates a passband inside the wavelength rejection band. During the inscription of Type II Bragg gratings broadband, optical loss is induced in the fiber core as a result of interaction between the inscription beam and the silica host. The amount of broadband loss will determine the passband's spectral characteristics (bandwidth and loss).
An Active Magnetic Probe Array for the Multiple-Point Concurrent Measurement of Electromagnetic Emissions (2006)

In order to diagnose the EMI (Electromagnetic Interference) problem of ICs, an integrated active magnetic probe array has been developed in SOI (Silicon On Insulator)-CMOS technology. Three aligned differential coils, differential amplifiers, a differential to single-ended converter, an output buffer and bias circuits are all integrated in a single-chip. A measurement result shows that the probe achieves an e-field suppression ratio of 33.6 dB at 50 MHz. Furthermore, a two-dimensional magnetic field distribution map is drawn by the probe array using the 3-point concurrent measurement. The obtained image gains three times higher resolution than that of a single scan under an identical condition