gebhart/patrepeval huggingface dataset:
A Wideband 2<formula formulatype="inline"><tex Notation="TeX">$\times$</tex> </formula>13-bit All-Digital I/Q RF-DAC (2014)

This paper presents a wideband 2 ×13-bit in-phase/quadrature-phase (I/Q) RF digital-to-analog converter-based all-digital modulator realized in 65-nm CMOS. The isolation between I and Q paths is guaranteed employing 25% duty-cycle differential quadrature clocks. With a 1.3-V supply and an on-chip power combiner, the digital I/Q transmitter provides more than 21-dBm RF output power within a frequency range of 1.36-2.51 GHz. The peak RF output power, overall system, and drain efficiencies of the modulator are 22.8 dBm, 34%, and 42%, respectively. The measured static noise floor is below -160 dBc/Hz. The digital I/Q RF modulator demonstrates an IQ image rejection and local oscillator leakage of -65 and -68 dBc, respectively. It could be linearized using either of the two digital predistortion (DPD) approaches: a memoryless polynomial or a lookup table. Its linearity is examined using single-carrier 4/16/64/256/1024 quadrature amplitude modulation (QAM), as well as multi-carrier 256-QAM orthogonal frequency-division multiplexing baseband signals while their related modulation bandwidth can be as high as 154 MHz. Employing DPD improves the third-order intermodulation product (IM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) by more than 25 dB, while the measured error vector magnitude for a “single-carrier 22-MHz 64-QAM” signal is better than -28 dB.
5G V2X Architecture and Radio Aspects (2019)

3GPP standardization is evolving beyond 5G the New Radio air interface (NR-Uu) framework defined in 3GPP Release 15 (also known as 5G phase 1) to study the support of advanced vehicle to everything (V2X) services. The NR Sidelink (SL) being designed in 3GPP Release 16 (5G phase 2) to support advanced V2X services directly between vehicles and other road users is expected to finish by the end of 2019. The advanced V2X services primarily focuses on platooning, advanced driving, extended sensor and remote driving use-cases. Supporting an end-to-end latency of 3ms and high reliability up-to 99.999% requirement requires substantial improvements in the air-interface design. Long Term Evolution (4G LTE) V2X sidelink supports the delivery of Basic Safety Messages to nearby V2X User Equipments (UE, the mobile device), hence the sidelink physical layer and the higher protocol layers are designed to support only broadcast type traffic without Hybrid Automatic Repeat Request (HARQ) feedback. With the advanced V2X service requirement, NR sidelink design should study V2X message delivery for different cast types such as unicast, groupcast and broadcast type traffics that requires substantial changes starting in V2X Release 16 network architecture, physical and protocol layers. This paper provides insights on the current Release 16 NR sidelink design for V2X. The network architecture enhancement discusses supporting flow- based Quality of Service (QoS) model for NR sidelink and the newly introduced network entities such as Network Data Analytics Function (NWDAF) providing QoS analytic. The design of the NR sidelink physical layer based on the Cyclic- Prefix Orthogonal Frequency-Division Multiplexing (CPOFDM) waveform addresses the necessary improvements needed in the sidelink procedures for reliable packet transmissions in a certain communication range. The protocol layer introduces a new overlapping zone concept to study both about HARQ feedback in a communication range and the resource segregation.
Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men (2021)

The number of older obese adults is increasing worldwide. Whether obese adults show similar health benefits in response to lifestyle interventions at different ages is unknown. The study enrolled 25 obese men (body mass index: 31-39 kg/m<sup>2</sup>) in two arms according to age (30-40 and 60-70 yr old). Participants underwent an 8-wk intervention with moderate calorie restriction (∼20% below individual energy requirements) and supervised endurance training resulting in ∼5% weight loss. Body composition was measured using dual energy X-ray absorptiometry. Insulin sensitivity was assessed during a hypersinsulinemic-euglycemic clamp. Cardiometabolic profile was derived from blood parameters. Subcutaneous fat and vastus lateralis muscle biopsies were used for ex vivo analyses. Two-way repeated-measure ANOVA and linear mixed models were used to evaluate the response to lifestyle intervention and comparison between the two groups. Fat mass was decreased and bone mass was preserved in the two groups after intervention. Muscle mass decreased significantly in older obese men. Cardiovascular risk (Framingham risk score, plasma triglyceride, and cholesterol) and insulin sensitivity were greatly improved to a similar extent in the two age groups after intervention. Changes in adipose tissue and skeletal muscle transcriptomes were marginal. Analysis of the differential response to the lifestyle intervention showed tenuous differences between age groups. These data suggest that lifestyle intervention combining calorie restriction and exercise shows similar beneficial effects on cardiometabolic risk and insulin sensitivity in younger and older obese men. However, attention must be paid to potential loss of muscle mass in response to weight loss in older obese men.<b>NEW & NOTEWORTHY</b> Rise in obesity and aging worldwide are major trends of critical importance in public health. This study addresses a current challenge in obesity management. Do older obese adults respond differently to a lifestyle intervention composed of moderate calorie restriction and supervised physical activity than younger ones? The main conclusion of the study is that older and younger obese men similarly benefit from the intervention in terms of cardiometabolic risk.
GATA-Like Protein-1 (GLP-1): A Novel Factor Required for Ovarian Development. (2009)

GLP-1 is a member of the GATA transcription factor family. However, due to differences in the protein sequence surrounding its second zinc finger, GLP-1 does not directly bind to DNA and activate transcription. Instead, in vitro experiments suggest that GLP-1 is a novel transcriptional repressor of GATA4 and GATA6. In the adult female mouse ovary, granulosa cells express GLP-1 along with GATA4 and GATA6 transcription factors. GATA4 and GATA6 are known regulators of granulosa cell proliferation and function in the ovary. To investigate the in vivo function of GLP-1, the entire glp-1 locus was replaced with β-galactosidase. These ovaries are nearly completely devoid of oocytes and follicles at birth, and remain shrunken in size for several weeks after birth. Close observation of ovaries from females six months of age revealed 30% of these ovaries (n=10) are as large as their wild-type littermates in the absence of germ cells and resemble tubular adenomas. We have focused our efforts to understand the function of GLP-1 during early ovarian development. We hypothesize that during embryogenesis, pregranulosa cells in the GLP-1 null ovary are unable to participate in programmed cyst breakdown and subsequent primordial follicle formation, resulting in apoptosis of the germ cells. To examine cyst formation and subsequent programmed cyst breakdown, we carefully followed laminin expression, a major component of the basement membrane, from E14.5 through birth. We also analyzed oocyte and granulosa cell apoptosis at the same developmental time points by performing co-localization studies using immunofluorescence. We labeled germ cells with GCNA1 and identified apoptotic cells by staining for activated caspase-3. These data demonstrated an increase in germ cell apoptosis in GLP-1 null ovaries from E16.5 through birth. In contrast, laminin staining from E14.5 through birth was identical in wild-type and GLP-1 null mice, suggesting that pregranulosa cells surround developing cysts normally. These studies indicate that, despite GLP-1 being expressed in granulosa cells, the pregranulosa cells are migrating and functioning normally during embryogenesis in the GLP-1 null ovary. This implies that the primary defect is oocyte survival and that GLP-1 may play an important role in the early granulosa cell-oocyte cross-talk. In fact, paracrine signaling between the oocyte and pregranulosa cells during programmed cyst breakdown is known to be important during late embryogenesis for oocyte survival. (poster)
Generation of Forward Phase-Conjugate Beam by Cu:KNSBN-Cat Type Self-Pumped Phase-Conjugator (1999)

A forward phase-conjugate beam was generated using a copper-doped (K 0.5 Na 0.5 ) 0.2 (Sr 0.61 Ba 0.39 ) 0.9 Nb 2 O 6 (Cu:KNSBN) crystal with Cat type self-pumped phase-conjugator incident geometry. This Cat self-pumped phase-conjugator was formed simply with a small incident beam diameter of 0.4 mm at an incidence angle of 30°. In this configuration, the forward phase-conjugate beam could be generated at the same time with the self-pumped phase-conjugate beam. Furthermore, it was possible to generate the forward phase-conjugate beam while maintaining the high reflectivity of the self-pumped phase-conjugate beam. A forward phase-conjugate reflectivity of 0.9% was achieved at a self-pumped phase-conjugate reflectivity of 12%.
Strain relaxation in epitaxial Si1-xGexlayers during some silicidation processes (1994)

Strain relaxation in Si1-xGex epitaxial layers is investigated after the reaction of Co and Pt with strained SiGe alloy. The epitiaxial SiGe alloy studied has a Ge fraction ranging between x = 5% to 22%. The strain in the Si1-xGex is evaluated using multi-crystal high resolution x-ray diffraction mapping in reciprocal space (MC-HRXRD). The results show that for Co in order to keep the strain in Si1-xGex unaffected, a sacrificial Si layer is needed. The direct reaction of 40 nm Co on Si0.9Ge0.1 can lead to defect formation and 40% strain relaxation. This is in contrast to Pt/Si1-xGex reaction, where negligible relaxation was observed.
Periprocedural Cardiopulmonary Bypass or Venoarterial Extracorporeal Membrane Oxygenation During Transcatheter Aortic Valve Replacement: A Systematic Review (2018)

CPB/VA-ECMO was used in 4% in the early experience of patients undergoing transcatheter aortic valve replacement, most commonly for periprocedural complications. There are limited data on preprocedural planned use of VA-ECMO, and the characteristics of this population remain poorly defined.
Hierarchical reliable multicast (2000)

The use of proxies for local error recovery and congestion control is a scalable technique used to overcome a number of well-known problems in Reliable Multicast (RM). The idea is that the multicast delivery tree is partitioned into subgroups that form a hierarchy rooted at the source, hence the term Hierarchical Reliable Multicast (HRM). For each subgroup, there is a designated node, the proxy, which is responsible for collecting the feedback from the subgroup and for locally re-transmitting the lost packets. The performance of any RM protocol is affected by the underlying multicast routing tree and its loss characteristics. Furthermore, the performance of the HRM approach, in particular, strongly depends on the appropriate partitioning of the tree and the selection of proxies. In this paper, we first model the HRM problem, then define and compute appropriate performance metrics and finally give insights on the optimal location of proxies.
Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy (2010)

Current cancer management aims to integrate molecular signatures into the design of personalized therapies. Recent advances in "omics" done on tumor specimens have led to the identification of factors that either recognize cancers of dismal prognosis or pinpoint "druggable" signaling pathways, which can be interrupted by targeted therapies. However, accumulating evidence underscores the biological and clinical significance of immune predictors in several compartments (blood, serum, tumor) in a variety of malignancies. An additional aspect that has been overlooked is the bidirectional, tumor-host interaction during therapeutic intervention, suggesting that dynamic molecular, biochemical, and metabolic signatures should be developed in the future. We review immune parameters of prognostic or predictive value during cancer therapy, and highlight existing "descriptive-prognostic" and "functional-therapeutic" molecular signatures, with the hindsight of designing appropriate compensatory therapies.
Poor Survival After Retransplantation in NASH Cirrhosis (2018)

Despite the comparable outcomes reported for initial LT among the various etiologies, the outcome of re-LT is significantly worse for NASH cirrhosis.
Isolated pseudo–RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition (2013)

Serine/arginine (SR) proteins, one of the major families of alternative-splicing regulators in Eukarya, have two types of RNA-recognition motifs (RRMs): a canonical RRM and a pseudo-RRM. Although pseudo-RRMs are crucial for activity of SR proteins, their mode of action was unknown. By solving the structure of the human SRSF1 pseudo-RRM bound to RNA, we discovered a very unusual and sequence-specific RNA-binding mode that is centered on one α-helix and does not involve the β-sheet surface, which typically mediates RNA binding by RRMs. Remarkably, this mode of binding is conserved in all pseudo-RRMs tested. Furthermore, the isolated pseudo-RRM is sufficient to regulate splicing of about half of the SRSF1 target genes tested, and the bound α-helix is a pivotal element for this function. Our results strongly suggest that SR proteins with a pseudo-RRM frequently regulate splicing by competing with, rather than recruiting, spliceosome components, using solely this unusual RRM.
Annealing of Cocontinuous Polymer Blends: Effect of Block Copolymer Molecular Weight and Architecture (2010)

Cocontinuous morphologies of polymer blends are thermodynamically unstable: they will coarsen when held above their glass or melting transition temperature. We have found that properly chosen diblock copolymers (bcp) can arrest coarsening during quiescent annealing. The effects of bcp on the cocontinuous morphologies of polystyrene (PS)/polyethylene (PE), PS/poly(methyl methacrylate) (PMMA) and PS/styrene-ran-acrylonitrile copolymer (SAN) blends were studied using scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM) with image analysis. Bcp effectiveness was dependent on copolymer molecular weight, concentration, and asymmetry. Our interpretation emphasizes the role of bcp micelle creation and destruction as potential bottlenecks in the kinetics of interfacial adsorption of copolymer during mixing and of interfacial desorption during coarsening. In cases where adsorption and desorption appear to be facile, our results for the rate of coarsening are consistent with equilibrium predictions from self-consistent field theory for the dependence of interfacial tension upon copolymer asymmetry. We show that the coarsening of cocontinuous blends can provide a method to quantify the reduction in interfacial tension due to block copolymer addition, which is difficult to measure by conventional methods.
Thermochemical Calculation of the Quaternary CaO–SiO2–Al2O3–MgO System at 1600°C for Predicting the MgO‐Saturation and MgO–MgO · Al2O3 Equilibrium of Secondary Metallurgical Slag (2013)

Different quaternary CaO–SiO 2 –Al 2 O 3 –MgO systems were calculated with thermochemical‐calculations at various temperatures by using FactSage6.2. The calculated systems provide enhanced knowledge of secondary metallurgical ladle slag conditions at process temperatures. These systems can also be used for predicting the MgO‐saturation and the MgO–MgO · Al 2 O 3 equilibrium at various temperatures for commonly used ladle slag compositions.
A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes (2021)

Abstract The Nile rat ( Avicanthis niloticus ) is an important animal model for biomedical research, including the study of diurnal rhythms and type 2 diabetes. Here, we report a 2.5 Gb, chromosome-level reference genome assembly with fully resolved parental haplotypes, generated with the Vertebrate Genomes Project (VGP). The assembly is highly contiguous, with contig N50 of 11.1 Mb, scaffold N50 of 83 Mb, and 95.2% of the sequence assigned to chromosomes. We used a novel workflow to identify 3,613 segmental duplications and quantify duplicated genes. Comparative analyses revealed unique genomic features of the Nile rat, including those that affect genes associated with type 2 diabetes and metabolic dysfunctions. These include 14 genes that are heterozygous in the Nile rat or highly diverged from the house mouse. Our findings reflect the exceptional level of genomic detail present in this assembly, which will greatly expand the potential of the Nile rat as a model organism for genetic studies.
Poly(enonsulfides) from the addition of aromatic dithiols to aromatic dipropynones (1987)

Abstract Novel poly(enonsulfides) were prepared with inherent viscosities as high as 1.35 dL/g by nucleophilic addition of various aromatic dithiols to 1,1′‐(1,3‐ or 1,4‐phenylene)bis(3‐phenyl‐2‐propyn‐1‐one) in m ‐cresol at 25–40°C. A tough clear yellow film with a tensile strength of 11,300 psi and a tensile modulus of 466,000 psi at 25°C was cast from a chloroform solution of the polymer prepared from 1,3‐dithiobenzene and 1,1′‐(1,4‐phenylene)bis(3‐phenyl‐2‐propyn‐1‐one). The poly(enonsulfides) exhibited T g 's as high as 180°C and weight losses of approximately 10% at 331°C in air. The synthesis and characterization of several poly(enonsulfides) are discussed.
Experimental Investigation on Nonlinear Distortions with Perturbation Back-propagation Algorithm in 224 Gb/s DP-16QAM Transmission (2012)

We investigate the impact of perturbation back-propagation algorithm on distribution of nonlinear noise in 224 Gb/s DP-16QAM transmission over large-Aeff pure silica core fiber and show the distribution approaches to Gaussian by the nonlinear compensation.
A proposal to use the justification bits of a DS-3 stream for signaling (1990)

The derivation of a signaling channel using the redundant justification bits in the DS-3 signal is proposed to remedy the DS-3 networks lack of overhead for support of intelligent network functions. In the DS-3 network each frame of 680 time slots contains one time slot (a stuff slot) that can be used to either transmit information from an appropriate tributary or to fill out the format. In the latter case, the redundant time slot can be used to carry auxiliary signaling information. It is proposed to use the random sequence of all these redundant time slots as the basis for the new signaling channel. It is shown that the information capacity of the resulting channel is 23 kb/s. This capacity is more than sufficient to implement the network management techniques in DS-3 networks and has the advantage of complete transparency to the existing payloads and to existing or new equipment not intended to process such signaling channels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Protective Role of ADAMTS13 for Myocardium in Mouse Model of Experimental Myocardial Infarction. (2012)

Abstract Abstract 2175 The metalloprotease ADAMTS13 regulates the size of von Willebrand factor (VWF) multimers, controlling excessive VWF functions and preventing thrombotic occlusion of microvasculature. We previously reported that ADAMTS13 deficiency aggravated the extent of brain ischemic stroke in a mouse model of middle cerebral arterial occlusion, suggesting the relevant role of ADAMTS13 in the pathophysiology of brain stroke (Fujioka, et al. Blood, 2010; 115: 1650). These results raised the possibility that the functional regulation of VWF by ADAMTS13 could also play a role in coronary ischemic events such as myocardial infarction. To address this issue, we have used a mouse model of experimental myocardial infarction. The left anterior descending coronary artery in mice was ligated at 2 mm downstream from the origin under thoracotomy with ventilator-assisted respiration, and the cardiac function was evaluated with M-mode echocardiography after 7 days of operation. We compared 20 wild-type (WT) mice and 20 Adamts13 −/− (KO) mice, all of which were 12–14 weeks of age, healthy and fertile. Significantly (p &lt; 0.01) decreased ejection fraction (EF; 44.0±6.7%) and increased left ventricular end-diastolic diameter (LVDd; 4.68±0.69 mm) of KO mice, as compared to WT (EF; 62.7±13.0% and LVDd; 3.77±0.56 mm, respectively), revealed that cardiac functions were apparently more impaired in KO mice. In addition, these reduced cardiac functions observed in KO mice were improved to an extent comparable to those of WT mice by the bolus injection of recombinant human ADAMTS13 (rhADAM; 3 μg/mouse, n=20) just after the operation (KO mice + rhADAM, EF; 58.2.±9.9% and LVDd; 3.16±0.52 mm). Consistent with echocardiography data, histological studies demonstrated the significantly (p &lt; 0.01) higher infarct ratio in myocardium of KO mice (WT; 37.3±18.4%, KO; 59.1±16.3%, KO + rhADAM; 33.7±24.4%). Our results indicate that ADAMTS13, as seen in the case of brain ischemic stroke, plays a protective role for myocardium in coronary artery ischemia, improving myocardial functions and the severity of heart failure. Proper functional regulation of VWF-dependent thrombotic or inflammatory responses by ADAMTS13 could reduce thrombotic occlusion of microvasculature including leukocyte plugging, contributing to better local microcirculation which is crucial for tissue or organ functions. Disclosures: No relevant conflicts of interest to declare.
Advances in Chronic Kidney Disease 2008 (2008)

The volumes in this series are published annually on the occasion of the International Conference on Dialysis organized by the Renal Research Institute, New York, in collaboration with the ISN, ISPD, NKF and RPA. Among the topics discussed in the current issue are the relationship between the metabolic syndrome, diabetes and kidney disease; impli
ChemInform Abstract: 6,9α‐OXIDO‐11α,15α‐DIHYDROXYPROSTA‐6,(E)‐13‐DIENOIC ACID METHYL ESTER AND 6,9α‐6,11α‐DIOXIDO‐15α‐HYDROXYPROST‐(E)‐13‐ENOIC ACID METHYL ESTER. TWO ISOMERIC FORMS OF PROSTACYCLIN (PGI2) (1978)

Abstract Die Synthesen der beiden Titelverbindungen (III) und (V) aus PGI, (I) bzw. ö‐Keto‐PGFla (IV) werden beschrieben.