gebhart/patrepeval huggingface dataset:
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (2021)

Abstract Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies demonstrated attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound showed exceptional in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocked P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identified ACS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. MMV693183 was well adsorbed after oral administration in mice, rats and dogs. Pharmacokinetic – pharmacodynamic modelling predicted that a single 30 mg oral dose is sufficient to cure a malaria infection in humans. In conclusion, the ACS-targeting compound MMV693183 represents a promising addition to the portfolio of antimalarials in (pre)clinical development with a novel mode of action for the treatment of malaria and blocking transmission.
Structure and speciation of chromium ions in chromium doped Fe2O3catalysts (2012)

In this paper, we report a detailed characterisation of chromium doped iron oxide catalysts using a range of techniques to establish the nature of chromium species in the near surface and bulk of iron oxide, high-temperature shift (HTS) catalysts. In particular we have employed X-ray absorption spectroscopy Cr K-edge near edge and extended fine structure data for comparison with chemical and X-ray photoelectron spectroscopy. There was excellent agreement between the techniques in terms of identification and quantification of Cr(6+) and Cr(3+) species as a function of calcination temperatures between 100 and 500 °C.
Compressor Development for Space-Based Hyperbaric Chambers (2002)

&lt;div class="htmlview paragraph"&gt;This paper describes new advances in compressor technology for space-based human health maintenance and countermeasure systems. Specifically, NASA is developing an on-board hyperbaric chamber to treat decompression sickness in crewmembers during long-term space missions. Presently, they do not have pressurization, oxygen delivery, or environmental control subsystems that will operate in zero gravity. Commercial, earth-based compressors typically require gravity-circulated lubrication oil for bearings. An innovative, lubrication-free compressor was designed for space-based hyperbaric chamber pressurization and oxygen delivery subsystems. Compressor components were fabricated and the potential of the new compressor was experimentally validated. The compressor, including power and control equipment weighs 80% less than, occupies 84% less space than, and uses 43% less power than state-of-the-art, commercial, terrestrial systems. Oil-less compressor design for a separate active environmental control subsystem is also discussed.&lt;/div&gt;
Process Cost and Time in Minimal Fab to Fabricate Custom-made Microneedle Array with Extraction Tool (2018)

This work presents, for the first time, the study of fabrication time together with running cost of a microneedle array fabricated using minimal fab. A Si hollow-microneedle array was fabricated on a half inch wafer within 7 hours and its process cost was less than $10/chip although the process was only one chip production. A portable and disposable dropper is simply produced and assembled with microneedle array for the application of liquid extraction that may extend to be used as a blood extraction tool. The extracted liquid by one finger-push and release, up to 0.8 ml of liquid can be drawn and store in the dropper.
HybridOS (2008)

We present HybridOS, a set of operating system extensions for supporting fine-grained reconfigurable accelerators integrated with general-purpose computing platforms. HybridOS specifically targets the application integration, data movement and communication overheads for a CPU/accelerator model when running a commodity operating system. HybridOS provides a simple API for applications and a well-defined hardware interface for reconfigurable accelerators. The goal is to reduce the difficulty in mapping applications into a CPU/accelerator model compared to an unrestrained FPGA platform while achieving whole-application speedups. HybridOS is integrated into a full Linux distribution running on the embedded processor of an FPGA. Application-specific accelerators are implemented in the reconfigurable fabric of the FPGA that are allocated to user applications running on Linux. We have developed and evaluated four methods for accessing the data buffers required by hardware-accelerated applications using our prototype. The results of our work show the feasibility of our system for a case study, JPEG encoding with two accelerators, and an evaluation of HybridOS for varying data movement requirements that can be used as a guide for future applications developers
MULTIPLEX META-ANALYSIS OF MEDULLOBLASTOMA EXPRESSION STUDIES WITH EXTERNAL CONTROLS (2013)

We propose and discuss a method for doing gene expression meta-analysis (multiple datasets) across multiplex measurement modalities measuring the expression of many genes simultaneously (e.g. microarrays and RNAseq) using external control samples and a method of heterogeneity detection to identify and filter on comparable gene expression measurements. We demonstrate this approach on publicly available gene expression datasets from samples of medulloblastoma and normal cerebellar tissue and identify some potential new targets in the treatment of medulloblastoma.
Design of High-k Interfacial Layer Formation by Cycle-by-Cycle Deposition and Annealing Method (2009)

We have developed a process for forming an ultra-thin high-k interfacial layer (HfSiOx-IL or AlSiOx-IL) for high-k gate stacks. The HfSiOx-IL and AlSiOx-IL was grown by Cycle-by-Cycle Deposition &amp; Annealing method (this method is called CC-D&amp;A, and the IL deposited by this method is called CC-IL). This method utilizes the solid-phase reaction between high-k films (HfO2 or Al2O3) and Si-substrate performed by repeating the sequence of 1 cycle ALD HfO2 (or Al2O3) deposition and RTA. The CC-IL enables the formation of very uniform films consisting of a few mono-layers. In this paper, we demonstrated the physical properties for CC-IL, and electrical properties for high-k gate stacks with CC-IL, and we achieved 0.5nm-EOT high-k gate stacks of CMOS with gate-first process.
Lutidine buffers of very limited coordination power for the pH range 3-8 (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLutidine buffers of very limited coordination power for the pH range 3-8Udo Bips, Horst Elias, Maria Hauroeder, Gerhard Kleinhans, Sigrid Pfeifer, and Klaus J. WannowiusCite this: Inorg. Chem. 1983, 22, 26, 3862–3865Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ic00168a009https://doi.org/10.1021/ic00168a009research-articleACS PublicationsRequest reuse permissionsArticle Views462Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crucial Role of CD40 Signaling in Vascular Wall Cells in Neointimal Formation and Vascular Remodeling After Vascular Interventions (2011)

CD40 signaling through TRAF6 in vascular SMCs seems to be centrally involved in neointimal formation in a NF-κB-dependent manner. Modulating CD40 signaling on local vascular wall may become a new therapeutic target against vascular restenosis.
Establishing blood group marker genes and comparing gross carcass parameters in normal and dystrophic New Hampshire chickens (1980)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Low-power design for real-time image segmentation LSI and compact digital CMOS implementation (2004)

We present a low-power design for real-time digital image segmentation LSI. We design the CMOS test-chip in a 0.35 /spl mu/m 2-Poly 3-Metal CMOS technology, based on a boundary active only architecture. The design area for 41 /spl times/ 31 pixels is 51.1mm/sup 2/ and the integration density is 26.5pixel/mm/sup 2/. From the circuit simulations at 3.3V supply voltage and 10MHz clock frequency, we obtain a power dissipation of 21.8mW and an image segmentation time of 23/spl mu/sec.
Autotuning Numerical Dense Linear Algebra for Batched Computation With GPU Hardware Accelerators (2018)

Computational problems in engineering and scientific disciplines often rely on the solution of many instances of small systems of linear equations, which are called batched solves. In this paper, we focus on the important variants of both batch Cholesky factorization and subsequent substitution. The former requires the linear system matrices to be symmetric positive definite (SPD). We describe the implementation and automated performance engineering of these kernels that implement the factorization and the two substitutions. Our target platforms are graphics processing units (GPUs), which over the past decade have become an attractive high-performance computing (HPC) target for solvers of linear systems of equations. Due to their throughput-oriented design, GPUs exhibit the highest processing rates among the available processors. However, without careful design and coding, this speed is mostly restricted to large matrix sizes. We show an automated exploration of the implementation space as well as a new data layout for the batched class of SPD solvers. Our tests involve the solution of many thousands of linear SPD systems of exactly the same size. The primary focus of our techniques is on the individual matrices in the batch that have dimensions ranging from 5-by-5 up to 100-by-100. We compare our autotuned solvers against the state-of-the-art solvers such as those provided through NVIDIA channels and publicly available in the optimized MAGMA library. The observed performance is competitive and many times superior for many practical cases. The advantage of the presented methodology lies in achieving these results in a portable manner across matrix storage formats and GPU hardware architecture platforms.
Measurement of CP observables in B±→D(⁎)K± and B±→D(⁎)π± decays (2017)

Measurements of CP observables in B D ( * ) K and B D ( * ) decays are presented, where D ( * ) indicates a neutral D or D * meson that is an admixture of D ( * )0 and D( * )0 states. Decays of the D * meson to the D 0 and D final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K , K + K -and + -final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb -1 taken at centre-of-mass energies of s = 7, 8 and 13 TeV,
Large-Margin Predictive Latent Subspace Learning for Multiview Data Analysis (2012)

Learning salient representations of multiview data is an essential step in many applications such as image classification, retrieval, and annotation. Standard predictive methods, such as support vector machines, often directly use all the features available without taking into consideration the presence of distinct views and the resultant view dependencies, coherence, and complementarity that offer key insights to the semantics of the data, and are therefore offering weak performance and are incapable of supporting view-level analysis. This paper presents a statistical method to learn a predictive subspace representation underlying multiple views, leveraging both multiview dependencies and availability of supervising side-information. Our approach is based on a multiview latent subspace Markov network (MN) which fulfills a weak conditional independence assumption that multiview observations and response variables are conditionally independent given a set of latent variables. To learn the latent subspace MN, we develop a large-margin approach which jointly maximizes data likelihood and minimizes a prediction loss on training data. Learning and inference are efficiently done with a contrastive divergence method. Finally, we extensively evaluate the large-margin latent MN on real image and hotel review datasets for classification, regression, image annotation, and retrieval. Our results demonstrate that the large-margin approach can achieve significant improvements in terms of prediction performance and discovering predictive latent subspace representations.
Penetration and Spreading of Liquid Jets in an External-Internal Compression Inlet (2000)

Injection of liquid fuel in the inlet of a vehicle e ying at hypersonic speed is related to the development of liquid fuel-based supersonic-combustion ramjets as a means to increasetheresidence timeand achieve partial fuel premixing priorto arrivalat thecombustion chamber. The strong liquid interactionwith theinlethigh-momentum aire owand shock wavesystem offersa mechanism forrapid jetand droplet breakup and, hence, improved mixing. The penetration and spreading of liquid jets in a two-dimensional external ‐internal compression inlet at Mach 3.5 using a noncombustible mixture that simulated the viscosity and surface tension of JP-10 was evaluated. Schlieren imaging has been used as the visualization technique for penetration studies, as well as light scattering for jet spreading. By using thin pylons to create a low-pressure region at the liquid injection station, the penetration increased compared with a nonpylon cone guration while reducing the pressure losses associated with transverse jet injection. The pylons contributed to lift the liquid from the injection surface with less lateral spreading than the nonpylon-injection case, thus avoiding the presence of a low-speed combustible mixture in the inlet/isolator boundary layers and providing a mechanism to eliminate potential e ashback.
Differentially Private Stochastic Coordinate Descent (2021)

In this paper we tackle the challenge of making the stochastic coordinate descent algorithm differentially private. Compared to the classical gradient descent algorithm where updates operate on a single model vector and controlled noise addition to this vector suffices to hide critical information about individuals, stochastic coordinate descent crucially relies on keeping auxiliary information in memory during training. This auxiliary information provides an additional privacy leak and poses the major challenge addressed in this work. Driven by the insight that under independent noise addition, the consistency of the auxiliary information holds in expectation, we present DP-SCD, the first differentially private stochastic coordinate descent algorithm. We analyze our new method theoretically and argue that decoupling and parallelizing coordinate updates is essential for its utility. On the empirical side we demonstrate competitive performance against the popular stochastic gradient descent alternative (DP-SGD) while requiring significantly less tuning.
Species identification and phylogenetic relationships based on partial HSP60 gene sequences within the genus Staphylococcus (1999)

The phylogenetic relationships among 36 validly described species or subspecies within the genus Staphylococcus were investigated by cloning and sequencing their 60 kDa heat-shock protein (HSP60) genes using a set of universal degenerate HSP60 PCR primers. The cloned partial HSP60 DNA sequences from nine Staphylococcus aureus strains were highly conserved (97-100% DNA sequence similarity; mean 98%), indicating that the HSP60 gene of multiple isolates within the same species have little microheterogeneity. At the subspecies level, DNA sequence similarity among members of S. aureus, Staphylococcus schleiferi, Staphylococcus cohnii and Staphylococcus capitis ranged from 91 to 98%. At the interspecies level, sequence similarity among 23 distinct species of staphylococci ranged from 74 to 93% (mean 82%). By comparison, the highest sequence similarity of Bacillus subtilis and Escherichia coli with members within the genus Staphylococcus was only 70 and 59%, respectively. Importantly, phylogenetic analysis based on the neighbour-joining distance method revealed remarkable concordance between the tree derived from partial HSP60 gene sequences and that based on genomic DNA-DNA hybridization, while 16S rRNA gene sequences correlated less well. The results demonstrate that DNA sequences from the highly conserved and ubiquitous HSP60 gene offer a convenient and accurate tool for species-specific identification and phylogenetic analysis of staphylococci.
Triarylamine siloxane anode functionalization/hole injection layers in high efficiency/high luminance small-molecule green- and blue-emitting organic light-emitting diodes (2007)

High efficiency/high luminance small-molecule organic light-emitting diodes (OLEDs) are fabricated by combining thin, covalently bound triarylamine hole injection/adhesion interlayers with hole- and exciton-blocking/electron transport interlayers in tris(8-hydroxyquinolato)aluminum(III) (Alq) and tetrakis(2-methyl-8-hydroxyquinolinato)borate (BQ4−)-based OLEDs. Green-emitting OLEDs with maximum luminance ∼85000cd∕m2, power and forward external quantum efficiencies as high as 15.2lm∕W and 4.4±0.5%, respectively, and turn-on voltages ∼4.5V are achieved in devices of the structure, ITO∕N,N′-diphenyl-N,N′-bis(p-trichlorosilylpropylphenyl)(1,1′-biphenyl)-4,4′-diamine (TPD-Si2)/1,4-bis(1-naphthylphenylamino)biphenyl (NPB)/Alq doped with N,N′-di(3-heptyl)quinacridone (DIQA)/2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (BCP)∕Li∕AgMg. Also, bright and efficient blue-emitting OLEDs with turn-on voltages ∼5.0V, maximum luminance ∼30000cd∕m2, and ∼5.0lm∕W and 1.6±0.2% power and external forward quantum efficiencies, respectively, are achieved in devices of the structure, ITO∕TPD-Si2∕NPB∕BQ4−∕BCP∕Li∕Al. TPD-Si2 interlayers are fabricated by spin casting N,N′-diphenyl-N,N′-bis(p-trichlorosilylpropylphenyl)(1,1′-biphenyl)-4,4′-diamine onto the ITO surface, while BCP interlayers are introduced by thermal evaporation. The excellent OLED performance is attributed to the differing functions of the above two interlayers: (1) The TPD-Si2 layer has a direct impact on hole injection by reducing the injection barrier and improving interfacial cohesion, and an indirect but strong effect on electron injection by altering internal electric fields. (2) The BCP layer, doped with lithium, directly reduces the electron injection barrier. Incorporation of both interlayers in OLED structures affords synergistically enhanced hole/electron injection and recombination efficiency. The results demonstrate a strategy to enhance OLED performance and an alternative strategy to increase electron density in electron-limited devices.
Research on a Simulation Algorithm for Artillery Firepower Assignment According to Region (2022)

This paper proposes a simulation algorithm for fire distribution by area to ground attack. Taking battalion as an example, the algorithm for battalion level fire distribution by area includes shooting mode calculation model, impact point calculation model, ammunition consumption calculation model and damage probability calculation model. Based on this algorithm, the software is implemented and applied to related projects. Combined with the actual project, good results have been achieved.
Computational Simulation of Accumulation of Expired Air in the Infant Cot (2000)

Accumulation and re-breathing of CO2 in expired air has been suggested as one possible explanation for the strong association between prone sleeping position and sudden infant death syndrome (SIDS). This preliminary study applying a modern computational fluid dynamics (CFD) program to simulate the aerodynamics in an infant cot supports the idea that accumulation of expired air may occur in the prone position. The literature dealing with the potential association between re-breathing of accumulated CO2 and SIDS is briefly reviewed.
Tapping Mode Atomic Force Microscopy Analysis of the Growth Process of Electroless Nickel‐Phosphorus Films on Nonconducting Surfaces (1997)

The growth process of electroless nickel‐phosphorous (NiP) films on nonconducting substrate was investigated quantitatively using tapping mode atomic force microscopy (TMAFM) with focus upon the nucleation density on the substrate surface. Three kinds of catalyzing processes were used for polyimide substrates to obtain nucleation densities of 900, 750, and 550 nuclei/μm2. The TMAFM observation showed that the film growth proceeds mainly through successive nucleation of fine "particles" with several nanometers in diameter and their three‐dimensional growth, and that the nucleation density influences the state of aggregation of the particles and hence the resulting surface topography. The lower nucleation density developed the rougher surface with larger "grains" with a diameter of ca. 80 nm. However, the effect of nucleation density decayed with film growth and eventually vanished at a thickness of ca. 2000 nm due to successive nucleation For comparison, the growth process of NiP on NiP coated Al substrate, which is used for rigid magnetic disk applications and has a higher nucleation density of 3000 nuclei/μm2, was also examined. This process resulted in a smooth surface without the formation of "aggregates." Based upon these results, the root‐mean‐square roughness and scaling analyses were performed to evaluate quantitatively the differences in growth process.
A low-noise, GaAs/AlGaAs, microwave frequency-synthesizer IC (1998)

We have developed a GaAs/AlGaAs frequency-synthesizer IC with a 5.5-GHz feedback divider, a 2-GHz reference divider, a 500-MHz phase-frequency detector, 1-ns charge-pump pulses, and a gain-normalized charge-pump output with /spl plusmn/8-mA peak current and an 18-pA//spl radic/Hz noise floor. The feedback divider allows continuously selectable divide ratios from 12 to 16383, and supports dual-modulus pulse-swallowing fractional synthesis with single-bit control. The reference divider allows continuously selectable divide ratios from 1 to 4095; an optional divide-by-four/five input prescaler extends the divide ratios to 20475. The chip consumes 1 W from +5 and -5.2 V supplies.