gebhart/patrepeval huggingface dataset:
Activation of dopamine D 4 receptors by ABT-724 induces penile erection in rats (2004)

Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here we report that the dopamine D(4) receptor plays a role in the regulation of penile function. ABT-724 is a selective dopamine D(4) receptor agonist that activates human dopamine D(4) receptors with an EC(50) of 12.4 nM and 61% efficacy, with no effect on dopamine D(1), D(2), D(3), or D(5) receptors. ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an effect that is blocked by haloperidol and clozapine but not by domperidone. A proerectile effect is observed after intracerebroventricular but not intrathecal administration, suggesting a supraspinal site of action. s.c. injections of ABT-724 increase intracavernosal pressure in awake freely moving rats. In the presence of sildenafil, a potentiation of the proerectile effect of ABT-724 is observed in conscious rats. The ability of ABT-724 to facilitate penile erection together with the favorable side-effect profile indicates that ABT-724 could be useful for the treatment of erectile dysfunction.
Mining Associations Between Genetic Markers, Phenotypes, and Covariates (2001)

We used Haplotype Pattern Mining, HPM [Toivonen et al., Am J Hum Genet 67:133-45, 2000], for gene localization in Genetic Analysis Workshop (GAW) 12 isolate data. In HPM, association is analyzed by searching all trait-associated haplotype patterns. Data mining algorithms are utilized to make the search efficient. The strength of the haplotype-trait associations is measured by a linear model, into which a pre-seelected set of covariates is incorporated. Marker-wise patterns of association are used for predicting the disease gene location. Genome-wide scans of susceptibility genes for affection status as well as for the quantitative traits (Q1-Q5) were performed. First analyses were made with small sample sizes, 63-94 trios per trait, which is compared with a pilot study of a larger complex disease-mapping project. Subsequently, the analysis was repeated with approximately 600 cases and 600 controls per trait to give higher power to the analyses. With small sample sizes, only the susceptibility genes having the strongest effects on the traits could be localized. The larger sample size gave very good results: all susceptibility genes, except one, could be correctly localized. First experiments on candidate genes suggested that HPM is applicable even to fine mapping of mutations in DNA sequence.
Value Propositions Provide a Roadmap for Convergent Research on Environmental Topics (2021)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTValue Propositions Provide a Roadmap for Convergent Research on Environmental TopicsPaul Westerhoff*Paul WesterhoffNanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona 85287-5306, United States*Phone: 480-965-2885; email: [email protected], .More by Paul WesterhoffView Biography, Amber WutichAmber WutichSchool of Human Evolution and Social Change, Arizona State University, Tempe, Arizona 85287-2402, United StatesMore by Amber Wutich, and Curt CarlsonCurt CarlsonWorcester Polytechnic Institute, Northeastern University, and Practice of Innovation, LLC, Portola Valley, California 94028, United StatesMore by Curt CarlsonCite this: Environ. Sci. Technol. 2021, 55, 20, 13579–13582Publication Date (Web):October 1, 2021Publication History Received26 July 2021Published online1 October 2021Published inissue 19 October 2021https://pubs.acs.org/doi/10.1021/acs.est.1c05013https://doi.org/10.1021/acs.est.1c05013article-commentaryACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2846Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Environmental modeling,Environmental science,Materials,Nanotechnology,Students Get e-Alerts
Human T-cell immunity against Bordetella pertussis analyzed at clonal level. (1988)

Cloned peripheral blood T lymphocytes from an immune donor were grown in interleukin 2 and tested for proliferation in response to inactivated Bordetella species (B. pertussis, B. parapertussis and B. bronchiseptica) and mutants deficient for the expression of virulence-associated antigens. All the T-cell clones obtained were CD4+8- and recognized specifically the Bordetella antigens when presented by autologous B cells. On the basis of the responsiveness to the whole inactivated bacteria, it was possible to cluster the twelve clones obtained into four groups with the following specificity: 1) filamentous hemagglutinin (FHA): 2) B. pertussis specific antigens; 3) virulence-associated Bordetella specific antigens; 4) non-virulence-associated Bordetella specific antigens. Employing two new B. pertussis deletion mutants, clone 6 (representative of cluster 1), was found to recognize the C-terminus of FHA. Furthermore, 3 out of 4 clones of cluster 3 were specifically stimulated by the soluble 69,000 MW protein from the outer membrane of B. pertussis. Surprisingly, none of the twelve clones obtained by stimulation in vitro with whole inactivated bacteria recognized PT. Thus, PT does not seem to be the most representative antigen on the whole inactivated bacteria. However, when a new generation of clones was obtained using soluble PT as the in vitro stimulus, it was observed that 11 clones of this group recognized this antigen. Furthermore, the majority of them was against the subunit S1 of PT. Therefore, we can conclude that a T-cell memory against PT exists in a donor who has had pertussis several years before. In conclusion, these results provide useful information in the attempt to obtain a simplified acellular vaccine for whooping cough.
A Semi-Infinite Integral Involving the Macdonald Function (1996)

Previous article Next article A Semi-Infinite Integral Involving the Macdonald FunctionM. Aslam Chaudhry and S. M. ZubairM. Aslam Chaudhry and S. M. Zubairhttps://doi.org/10.1137/1038125PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout"A Semi-Infinite Integral Involving the Macdonald Function." SIAM Review, 38(4), pp. 669–670[1] M. Aslam Chaudhry and , S. M. Zubair, Generalized incomplete gamma functions with applications, J. Comput. Appl. Math., 55 (1994), 99–124 10.1016/0377-0427(94)90187-2 96e:33005 0833.33002 CrossrefISIGoogle Scholar[2] A. Aslam Chaudhry, , N. M. Temme and , E. J. Veling, Asymptotics and closed form of a generalized incomplete gamma function, J. Comput. Appl. Math., 67 (1996), 371–379 10.1016/0377-0427(95)00018-6 97h:33005 0853.33003 CrossrefISIGoogle Scholar Previous article Next article FiguresRelatedReferencesCited byDetails Volume 38, Issue 4| 1996SIAM Review History Published online:17 February 2012 InformationCopyright © 1996 © Society for Industrial and Applied MathematicsPDF Download Article & Publication DataArticle DOI:10.1137/1038125Article page range:pp. 669-670ISSN (print):0036-1445ISSN (online):1095-7200Publisher:Society for Industrial and Applied Mathematics
Test structures for automated contactless inline wafer inspection (2002)

Simple but unique and space-saving microelectronic test structures were designed to afford automated inline contactless wafer inspection in a Scanning Electron Microscope (SEM) for rapid electrical defect-monitoring in the voltage contrast (VC) mode, along with in situ defect-isolation and -characterization capabilities. Such an automated technique can support accelerated yield learning on sub-0.25 /spl mu/m-rule designs as the defects get below the optical resolutions. The system is also capable of the traditional visual inspection in the secondary-electron emission mode, affording the determination of the transfer coefficients between optical inspection and electrical faults.
Organic LED Full Color Passive‐Matrix Display (1999)

Abstract A full color 5.2 inch 1/4VGA passive‐matrix organic LED display has been developed adopting selective deposition for the different emitting materials. The display features 320 (× 3) × 240 pixels with an equivalent pixel size of 0.33 × 0.33 mm 2 white peak luminance of over 150 cd/m 2 and power consumption of 6 W.
Mid-Infrared Difference-Frequency Generation in Suspended GaAs Waveguides (2013)

We experimentally demonstrate mid-infrared difference frequency generation in suspended 182-nm thick GaAs waveguides, enabled by form-birefringent phase-matching between the CW signal (1550 nm), pump (1025 nm), and idler (3025 nm).
Studies of the emission of quadruply bonded binuclear complexes in solution. Evidence for D4d distortions (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of the emission of quadruply bonded binuclear complexes in solution. Evidence for D4d distortionsVincent M. Miskowski, Robert A. Goldbeck, David S. Kliger, and Harry B. GrayCite this: Inorg. Chem. 1979, 18, 1, 86–89Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ic50191a019https://doi.org/10.1021/ic50191a019research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recombinant live attenuated avian coronavirus vaccines with deletions in the accessory genes 3ab and/or 5ab protect against infectious bronchitis in chickens (2018)

Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens, causing severe economic losses in poultry industry worldwide. Live attenuated viruses are widely used in both the broiler and layer industry because of their efficacy and ability to be mass applied. Recently, we established a novel reverse genetics system based on targeted RNA recombination to manipulate the genome of IBV strain H52. Here we explore the possibilities to attenuate IBV in a rational way in order to generate safe and effective vaccines against virulent IBV (van Beurden et al., 2017). To this end, we deleted the nonessential group-specific accessory genes 3 and/or 5 in the IBV genome by targeted RNA recombination and selected the recombinant viruses in embryonated eggs. The resulting recombinant (r) rIBV-Δ3ab, rIBV-Δ5ab, and rIBV-Δ3ab5ab could be rescued and grew to the same virus titer as recombinant and wild type IBV strain H52. Thus, genes 3ab and 5ab are not essential for replication in ovo. When administered to one-day-old chickens, rIBV-Δ3ab, rIBV-Δ5ab, and rIBV-Δ3ab5ab showed reduced ciliostasis as compared to rIBV H52 and wild type H52, indicating that the accessory genes contribute to the pathogenicity of IBV. After homologous challenge with the virulent IBV strain M41, all vaccinated chickens were protected against disease based on reduced loss of ciliary movement in the trachea compared to the non-vaccinated but challenged controls. Taken together, deletion of accessory genes 3ab and/or 5ab in IBV resulted in mutant viruses with an attenuated phenotype and the ability to induce protection in chickens. Hence, targeted RNA recombination based on virulent IBV provides opportunities for the development of a next generation of rationally designed live attenuated IBV vaccines.
Preparation of Novel Tetrathia[7]helicenes (2006)

Synthetic routes leading to functionalized tetrathia[7]helicenes have been developed. Initial formation of 3 via double Suzuki coupling is followed by functionalization and ring-closure (or with steps reversed) to give the desired helicenes in modest to good yields. Intermediate 3 could also be accessed by McMurry coupling (not shown). The physical and chemical properties of the helicenes are currently being studied, and attempts to prepare optically active samples are also underway.
Electrically Pumped Germanium-on-Silicon Laser (2012)

Germanium lasing from Ge-on-Si pnn heterojunction diode structures is demonstrated. Selective growth of highly phosphorus doped Ge in oxide trenches shows a design for CMOS compatible laser integration.
Figure S2 from The <i>MCT4</i> Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer (2023)

&lt;p&gt;Candidate MCT4 ASOs are able to inhibit PC-3 cell migration and tissue invasion in vitro. A) Treatment of PC3 cells with candidate MCT4 ASOs resulted in an inhibition of cell migration through a transwell, as indicated by a reduction in the number of migrated cells observed. B) Treatment with MCT4 ASO also inhibited the ability of PC-3 cells to invade Matrigel. As such, MCT4-mediated lactic acid secretion could play an important role in cancer metastasis.&lt;/p&gt;
Dependence of NMR noise line shapes on tuning, matching, and transmission line properties (2014)

The tuning and matching conditions of rf circuits, as well as the properties of the transmission lines connecting these to the preamplifier, have direct consequences for NMR probe sensitivity and as for the optimum delivery of rf power to the sample. In addition, tuning/matching conditions influence radiation damping effects, which manifest themselves as fast signal flip-back and line broadening effects, and can lead to concentration-dependent frequency shifts. Previous studies have also shown that the appearance of spin-noise and absorbed circuit noise signals heavily depended on tuning settings. Consequently, all these phenomena are linked together. The mutual connections and interdependences of these effects are highlighted and reviewed here.
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 (2015)

Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one X chromosome during development in female mammals. Despite extensive efforts to define the mechanism of Xist-mediated transcriptional silencing, we still do not know any proteins required for this role. The main challenge is that there are currently no methods to comprehensively define the proteins that directly interact with a lncRNA in the cell. Here we develop a method to purify a lncRNA from cells and identify proteins interacting with it directly using quantitative mass spectrometry. We identify ten proteins that specifically associate with Xist, three of these proteins--SHARP, SAF-A and LBR--are required for Xist-mediated transcriptional silencing. We show that SHARP, which interacts with the SMRT co-repressor that activates HDAC3, is not only essential for silencing, but is also required for the exclusion of RNA polymerase II (Pol II) from the inactive X. Both SMRT and HDAC3 are also required for silencing and Pol II exclusion. In addition to silencing transcription, SHARP and HDAC3 are required for Xist-mediated recruitment of the polycomb repressive complex 2 (PRC2) across the X chromosome. Our results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome.
Variability in the size of individual airways over the course of one year. (1995)

Several studies have examined the reproducibility over time of standard clinical measurements of pulmonary airways parameters, such as FEV1 and FVC. These studies indicate fairly consistent reproducibility of such measurements over periods of months and years. Although such traditional pulmonary function tests can provide quantitative measures of lung function, they do not provide any insight into the local or regional variation of individual airways. Therefore, in a longitudinal study in dogs, we directly measured the baseline size (cross-sectional area) of the same individual canine airways multiple times over a 1-yr period, using high-resolution computed tomography (HRCT). We compared the variability of individual airway size both within and between subjects to the various sizes of airways and to seasonal differences in size. Five anesthetized, intubated, and ventilated dogs were studied between five and eight times over a 15-mo period. HRCT scans were acquired at end expiration with the dogs at FRC on all occasions. All individual airways showed considerable variability in size over time as measured by the coefficient of variation (CV) (range: 9.2 to 69.3). The sizes of individual airways within a dog were seen to change by as much as twofold over time. Some dogs also showed significantly greater overall variability in airway size than did other dogs (p < 0.01), but this variability was related neither to the size of the airway (p = 0.34) nor to the season. These findings indicate a substantial local and regional variability in airway caliber that would not be detectable with conventional pulmonary function tests.(ABSTRACT TRUNCATED AT 250 WORDS)
New bounds on the permeability of a random array of spheres (1989)

The recently derived variational principle of Rubinstein and Torquato (submitted to J. Fluid Mech.) is applied to obtain new rigorous two- and three-point upper bounds on the fluid permeability k for slow viscous flow around a random array of identical spheres which may penetrate one another in varying degrees. The n-point bounds involve up to n-point correlation function information. Both bounds are simplified and computed for the special case of mutually impenetrable spheres for a wide range of sphere volume fractions. The three-point bound is sharp and provides significant improvement over the two-point bound, especially at high sphere volume fractions (low porosities). It is the sharpest upper bound on k for a random array of impenetrable spheres developed to date and begins to approach the Kozeny–Carman empirical relation at low porosities.
Total Synthesis and Structural Revision of Callipeltoside C (2008)

Auf den zweiten Blick: Besonders hervorzuheben in der 20-stufigen Synthese von Callipeltosid C sind eine prolinkatalysierte direkte Aldolreaktion, eine enantioselektive α-Oxyaminierung und der schnelle Aufbau des Kohlenhydratgerüsts durch De-novo-Synthese. Auf der Grundlage dieser Untersuchungen wird die Absolutkonfiguration der 2-O-Methylevalose-Einheit revidiert. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z800086_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
SYNTHESIS OF METHYL METHACRYLATE FROM COAL-DERIVED SYNGAS (1999)

Research Triangle Institute (RTI), Eastman Chemical Company, and Bechtel collectively are developing a novel three-step process for the synthesis of methyl methacrylate (MMA) from coal-derived syngas that consists of the steps of synthesis of a propionate, its condensation with formaldehyde to form methacrylic acid (MAA), and esterification of MAA with methanol to produce MMA. The research team has completed the research on the three-step methanol-based route to MMA. Under an extension to the original contract, we are currently evaluating a new DME-based process for MMA. The key research need for DME route is to develop catalysts for DME partial oxidation reactions and DME condensation reactions. Over the last quarter(Oct.-Dec./98), we have investigated the condensation between methyl propionate and formaldehyde (MP/HCHO=4.5/1) at various reaction temperatures(280-360EC) over 5%, 10%, and 20% Nb O /SiO catalysts. The conversion of HCHO increases with reaction 2 5 2 temperature and niobium loading. MMA+MAA selectivity goes through a maximum with the temperature over both 10% and 20% Nb O /SiO . The selectivities to MMA+MAA are 67.2%, 2 5 2 72.3%and 58.1% at 320EC over 5%, 10%, 20% Nb O /SiO , respectively. However, the 2 5 2 conversion of formaldehyde decreases rapidly with time on stream. The results suggest that silica supported niobium catalysts are active and selective for condensation of MP with HCHO, but deactivation needs to be minimized for the consideration of commercial application. We have preliminarily investigated the partial oxidation of dimethyl ether(DME) over 5% Nb O /SiO catalyst. Reactant gas mixture of 0.1% DME, 0.1% O and balance nitrogen is 2 5 2 2 studied with temperature ranging from 200°C to 500°C. The conversion of DME first increases with temperature reaching an maximum at 400°C then decreases. The selectivity to HCHO also increases with reaction temperature first. But the selectivity to HCHO decreases at temperature above 350°C accompanied by the increasing selectivity to CO . The results suggest that silica 2 supported niobium catalysts are active for partial oxidation of DME to HCHO. Best temperatures for partial oxidation are between 300 and 400°C. A short paper submitted to the ACS National Meeting at Anaheim(March 1999) was accepted for oral presentation. The title is �Catalytic Synthesis of Methacrylates over Silica Supported Niobium Catalysts� and will appear in the ACS preprints.