gebhart/patrepeval huggingface dataset:
Development and Evaluation of a Body-Worn Dosimeter for Continuous and Impulsive Noise (2022)

Noise exposure is encountered nearly everyday in both recreational and occupational settings, and can lead to a number of health concerns including hearing-loss, tinnitus, social-isolation and possibly dementia. Although guidelines exist to protect workers from noise, it remains a challenge to accurately quantify the noise exposure experienced by an individual due to the complexity and non-stationarity of noise sources. This is especially true for impulsive noise sources, such as weapons fire and industrial impact noise which are difficult to quantify due to technical challenges relating to sensor design and size, weight and power requirements. Because of this, personal noise dosimeters are often limited to a maximum 140 dB SPL and are not sufficient to measure impulse noise. This work details the design of a body-worn noise dosimeter (mNOISE) that processes both impulse and continuous noise ranging in level from 40 dBA-185 dBP (i.e. a quiet whisper to a shoulder fired rocket). Also detailed is the capability of the device to log the kurtosis of the sound pressure waveform in real-time, which is thought to be useful in characterizing complex noise exposures. Finally, we demonstrate the use of mNOISE in a military-flight noise environment. Clinical Relevance- On-body noise exposure monitoring can be used by audiologists industrial hygiene personnel and others to determine threshold of injury adequate hearing protection requirements and ultimately reduce permanent noise-induced hearing loss.
Geometrical Design Concept For Panoramic 3D Video Acquisition (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids. (2002)

The electronic properties of small molecules can be calculated quickly and with a reasonable degree of accuracy using semiempirical QM methods. In this study a set of QM properties derived from frontier electron theory have been used to produce a predictive model of the dissociation constants of phenols, benzoic acids and aliphatic carboxylic acids. The pKa values and structures of nearly 500 compounds were extracted from the Physprop database for this purpose. Multiple linear regression was used to search for relationships between pKa and the calculated QM properties. In most cases only a single independent variable, electrophilic superdelocalisability, was needed to produce a good model of pKa. The advantages of our approach are in the speed of calculation and the simplicity of the resultant models. The merits of using semiempirical methods to predict pKa are discussed in relation to previous studies.
Experimental investigations of seeding mechanisms of TMI in rod fiber amplifier using spatially and temporally resolved imaging (2020)

In this work we investigate transverse mode instability (TMI) in the presence of pump intensity noise and a controlled perturbation of the input coupling for a rod-type fiber amplifier using spatially and temporally resolved imaging (ST). We show that inherent pump intensity noise from the power supply can define significant peaks in the resulting TMI spectrum. ST measurements show that the TMI in the transition region consists of different orientations of LP<sub>11</sub>. This finding indicates that the simple picture of TMI being seeded by the combination of a static initial fraction of LP<sub>11</sub> and pump or signal intensity noise is not valid for our measurements. Furthermore we present seeding of TMI by perturbing the input coupling dynamically. ST measurements of the resulting TMI as a function of perturbation frequency provides quantitative information regarding the frequency response of the non-linear coupling coefficient. Finally, ST measurements of the resulting TMI as a function of signal power shows that the TMI experiences an exponential gain long before visible beam fluctuations appear.
Electron and proton conductivity of Fe-N-C cathodes for PEM fuel cells: A model-based electrochemical impedance spectroscopy measurement (2020)

Impedance spectra of a PEM fuel cell with three Fe-N-C cathodes have been measured under the H2/N2 testing regime. The spectra have been fitted using a recently developed physics-based impedance model, which takes into account finite proton (σp) and electron (σe) conductivity of the oxygen-free cathode catalyst layer. Fitting allowed to extract numerical data for σp, σe, the double layer capacitance, and the inductance of cables used for measuring impedance spectra. The values of σp and σe are close to what previously found for standard Pt/C electrodes, which is found for the first time using PGM-free catalysts. The method enables simultaneous measurement of reference proton and electron conductivity of PEMFC cathode.
Novel benzene-bridged macrobi- and macrotricyclic polyethers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel benzene-bridged macrobi- and macrotricyclic polyethersHaoyun An, Jerald S. Bradshaw, Krzysztof E. Krakowiak, Bryon J. Tarbet, N. Kent Dalley, Xiaolan Kou, Chengyue Zhu, and Reed M. IzattCite this: J. Org. Chem. 1993, 58, 27, 7694–7699Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/jo00079a013https://doi.org/10.1021/jo00079a013research-articleACS PublicationsRequest reuse permissionsArticle Views731Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Quantitation of ribonucleotides from base-hydrolyzed RNA using capillary zone electrophoresis (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitation of ribonucleotides from base-hydrolyzed RNA using capillary zone electrophoresisXiaohua. Huang, Jason B. Shear, and Richard N. ZareCite this: Anal. Chem. 1990, 62, 18, 2049–2051Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/ac00217a028https://doi.org/10.1021/ac00217a028research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exploiting Data Partitioning To Provide Approximate Results (2018)

Co-hash partitioning is a popular partitioning strategy in distributed query processing, where tables are co-located using join predicates. In this paper, we study the benefits of co-hash partitioning for obtaining approximate answers.
Structural analysis of specificity: .alpha.-lytic protease complexes with analogs of reaction intermediates (1989)

To better understand the structural basis of enzyme specificity, the structures of complexes formed between alpha-lytic protease, an extracellular serine protease of Lysobacter enzymogenes, and five inhibitory peptide boronic acids (R2-boroX, where R2 is methoxysuccinyl-Ala-Ala-Pro- and boroX is the alpha-aminoboronic acid analogue of Ala, Val, Ile, Norleu, or Phe) have been studied at high resolution by X-ray crystallography. The enzyme has primary specificity for Ala in the P1 position of peptide substrates with catalytic efficiency decreasing with increasing side-chain volume. Enzyme affinity for inhibitors with boroVal, boroIle, and boroPhe residues is much higher than expected on the basis of the catalytic efficiencies of homologous substrates. Covalent tetrahedral adducts are formed between the active-site serine and the boronic acid moieties of R2-boroAla, R2-boroVal R2-boroIle, and R2-boroNorleu. Though R2-boroVal is a slowly bound inhibitor and R2-boroAla is rapidly bound [Kettner, C. A., Bone, R., Agard, D. A., & Bachovchin, W. W. (1988) Biochemistry 27, 7682-7688], there appear to be no structural differences that could account for slow binding. The removal from solution of 20% more hydrophobic surface on binding accounts for the improved affinity of alpha-lytic protease for R2-boroVal relative to R2-boroAla. The high affinity of the enzyme for R2-boroIle derives from the selective binding of the L-allo stereoisomer of the boroIle residue, which can avoid bad steric interactions in the binding pocket.(ABSTRACT TRUNCATED AT 250 WORDS)
Primary Cilia of inv/inv Mouse Renal Epithelial Cells Sense Physiological Fluid Flow: Bending of Primary Cilia and Ca2+ Influx (2005)

Primary cilia are hypothesized to act as a mechanical sensor to detect renal tubular fluid flow. Anomalous structure of primary cilia and/or impairment of increases in intracellular Ca2+ concentration in response to fluid flow are thought to result in renal cyst formation in conditional kif3a knockout, Tg737 and pkd1/pkd2 mutant mice. The mutant inv/inv mouse develops multiple renal cysts like kif3a, Tg737 and pkd1/pkd2 mutants. Inv proteins have been shown to be localized in the renal primary cilia, but response of inv/inv cilia to fluid stress has not been examined. In the present study, we examined the mechanical response of primary cilia to physiological fluid flow using a video microscope, as well as intracellular Ca2+ increases in renal epithelial cells from normal and inv/inv mice in response to flow stress. Percentages of ciliated cells and the length of primary cilia were not significantly different between primary renal cell cultures from normal and inv/inv mutant mice. Localization of inv protein was restricted to the base of primary cilia even under flow stress. Inv/inv mutant cells had similar bending mechanics of primary cilia in response to physiological fluid flow compared to normal cells. Furthermore, no difference was found in intracellular Ca2+ increases in response to physiological fluid flow between normal and inv/inv mutant cells. Our present study suggests that the function of the inv protein is distinct from polaris (the Tg737 gene product), polycystins (pkd1 and pkd2 gene products).
Reliability improvement via antenna selection sensing in energy efficient spectrum access (2013)

In this paper a switch-stay model is proposed for spectrum access by a secondary user in the presence of a primary user, which considers the impact of spectrum handoff delay. This model is then studied to balance the trade-off between the secondary user's energy efficiency and transmission reliability in light of the probability of collision, throughput and delay constraints. Bounds on the probability of stay on the current channel are derived from multiple constraints. An antenna selection sensing mechanism is then proposed to relax these bounds by enhancing the sensing performance. The advantages of the proposed antenna selection sensing are verified by numerical results.
A Human Organization Analogy for Self-* Systems (CMU-CS-03-129) (2018)

The structure and operation of human organizations, such as corporations, offer useful insights to designers of self-* systems (a.k.a. self-managing or autonomic). Examples include worker/supervisor hierarchies, avoidance of micro-management, and complaint-based tuning. This paper explores the analogy, and describes the design of a self-* storage system that borrows from it.
Chemoprevention of Colorectal Cancer: Two Steps Forward, One Step Back? (2006)

Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality in the Western world. The poor survival rate has prompted the emphasis on prevention of this disease. Removal of adenomas at colonoscopy is highly effective and is the cornerstone of screening/surveillance strategies. However, screening efforts have had limited impact owing to low compliance with guidelines. Chemoprevention aims to prevent the development or recurrence of precancerous lesions and cancers with the use of compounds that block the carcinogenic process. A major advantage was the establishment and understanding of the multistage process of CRC carcinogenesis. Progress has been remarkable because of the availability of reliable animal models and clinical studies using colonic adenomas as a reliable and economic target for testing chemopreventive agents. Nonsteroidal anti-inflammatory drugs have drawn the most attention. Sulindac and celecoxib were shown to be effective in promoting polyp regression in high-risk individuals with familial adenomatous polyposis. In the more common sporadic setting, the Adenomatous Polyp PRevention On Vioxx (rofecoxib), Adenoma Prevention with Celecoxib and Prevention of Sporadic Adenomatous Polyps (celecoxib) trials have demonstrated a significant reduction in adenoma recurrence, but important concerns were raised regarding cardiovascular toxicity associated with selective cyclo-oxygenase-2 inhibitors. These landmark studies are very important, as they are a proof-of-concept that we can prevent CRC. More clinical studies are required to better select high-risk patients with safer regimens. Potential advantage versus risk for a given chemopreventive agent will have to be assessed on an individual basis. Currently, the only approved agent for chemoprevention is celecoxib in high-risk individuals with familial adenomatous polyposis.
How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative (2018)

Organic dye-tagged lipid analogs are essential for many fluorescence-based investigations of complex membrane structures, especially when using advanced microscopy approaches. However, lipid analogs may interfere with membrane structure and dynamics, and it is not obvious that the properties of lipid analogs would match those of non-labeled host lipids. In this work, we bridged atomistic simulations with super-resolution imaging experiments and biomimetic membranes to assess the performance of commonly used sphingomyelin-based lipid analogs. The objective was to compare, on equal footing, the relative strengths and weaknesses of acyl chain labeling, headgroup labeling, and labeling based on poly-ethyl-glycol (PEG) linkers in determining biomembrane properties. We observed that the most appropriate strategy to minimize dye-induced membrane perturbations and to allow consideration of Brownian-like diffusion in liquid-ordered membrane environments is to decouple the dye from a membrane by a PEG linker attached to a lipid headgroup. Yet, while the use of PEG linkers may sound a rational and even an obvious approach to explore membrane dynamics, the results also suggest that the dyes exploiting PEG linkers interfere with molecular interactions and their dynamics. Overall, the results highlight the great care needed when using fluorescent lipid analogs, in particular accurate controls.
Copper Tolerance Mediated by FgAceA and FgCrpA in Fusarium graminearum (2020)

All organisms must secure essential trace elements (e.g., Cu) for survival and reproduction. However, excess trace element accumulation in cells is highly toxic. The maintenance of copper (Cu) homeostasis has been extensively studied in mammals, bacteria, and yeast but not in plant pathogens. In this study, we investigated the molecular mechanisms of copper tolerance in <i>Fusarium graminearum</i>, the important wheat head scab fungus. RNA-seq revealed induced expression of the P-type ATPase transporter <i>FgCrpA</i> and metallothionein (MT) <i>FgCrdA</i> after excess Cu treatment. Deletion of <i>FgCrpA</i> but not <i>FgCrdA</i> resulted in reduced tolerance to Cu toxicity. The "Cu fist" transcription factor FgAceA was involved in Cu detoxification through activation of <i>FgCrpA</i>. △FgAceA was more sensitive to copper toxicity than △FgCrpA and overexpression of <i>FgCrpA</i> restored copper tolerance in △FgAceA. <i>FgAceA</i> negatively regulated aurofusarin production and its biosynthetic gene expression. △FgCrpA and △FgAceA were reduced in virulence in flowering wheat heads and synthesized decreased amounts of the mycotoxin deoxynivalenol when challenged with excess Cu. Taken together, these results suggest that mediation of Cu tolerance in <i>F. graminearum</i> mainly relies on the Cu efflux pump and that <i>FgAceA</i> governs Cu detoxification through activation of <i>FgCrpA</i>.
Photodynamic Therapy: Killing cancer gently with visible light (2023)

Photodynamic Therapy: Killing cancer gently with visible light Drs. Mary Potasek, Evgueni Parilov, and Karl Beeson, who are all co-founders of Simphotek, Inc have been using a novel therapeutic modality known as Photodynamic Therapy (PDT) to treat cancer, with far fewer side effects than traditional radiation x-ray methods. By using near-infrared or “gentle” visible light, this PDT does not cause nausea as chemotherapy does, does not damage ordinary tissue as x-ray radiation does, nor does it require removing or damaging parts of the body as surgery does. Simphotek has been supported by the United States National Institute of Health (NIH) to create such a simulation research tool for solid cancers and it’s called Dosie™. Dosie is the first comprehensive tool to simulate the PDT process including the light transport, drug, and molecular oxygen interactions to create the cytotoxic agent, singlet oxygen, which kills cancer. The goal is to treat a tumor’s greatest volume with the least exposure to the major blood vessels or other sensitive areas, which the researchers hope that this clinical trial will bring them one step closer to their aim of treating patients as safely and effectively as possible.
Asymptotic tracking for linear systems with actuator saturation by output feedback control (2001)

This paper is concerned with asymptotic tracking for linear systems with actuator saturation by output feedback control. Both reference inputs and disturbances are represented as zero-input responses of linear systems. The controller includes the internal model with an anti-windup term for the reference and disturbance signals and a state observer for the system to allow output feedback control. The overall system is shown to be asymptotically stable for any initial condition of the system as long as the magnitudes of the reference and disturbance signals are sized such that the asymptotic tracking of the reference signal can be achieved without saturating the actuator. A simulation example is presented to verify the effectiveness of the proposed approach.
Flexible metro network architecture based on wavelength blockers and coherent transmission (2019)

A flexible semi-filterless architecture for metro DWDM networks with ring- or horseshoe topologies is presented. ROADM nodes are based on wavelength blockers. Coherent transmission enables filterless channel selection. Critical parameters are determined and a 4-span, 160-km horseshoe with 100Gbit/s DP-QPSK and 200Gbit/s DP-16QAM is demonstrated.
Time-domain numerical solution of the KZK equation for modeling sound beams radiated by rectangular sources (1999)

A time-domain numerical solution of the KZK equation for modeling finite-amplitude sound beams radiated by rectangular sources similar to those used in diagnostic ultrasound is presented. The KZK equation accounts for the effects of diffraction within the parabolic approximation, nonlinearity, and thermoviscous absorption, on the propagation of sound beams. The algorithm is based on that used by Lee and Hamilton [J. Acoust. Soc. Am. 97, 906–917 (1995)] to model circular sources. The diffraction integral has the form of a two-dimensional diffusion equation. The implicit backward finite difference (IBFD) scheme adapted for two dimensions is used in the near field, where the solution tends to be oscillatory. For the remainder of the field, the alternate direction implicit (ADI) method is used for higher accuracy with larger steps than those used in IBFD. The simulation model may be used to predict the FDA regulatory measurements of medical diagnostic scanners.
Radical Hysterectomy for Cervical Cancer in Obese Women (2000)

In Brief Objective To estimate the morbidity, adequacy of surgery, and survival of obese women undergoing radical hysterectomy and pelvic lymphadenectomy. Methods Patients with stage I and IIa cervical cancer and a body mass index (BMI) over 30 kg/m2 and absolute weight greater than 85 kg explored with the intent for radical hysterectomy between 1986 and 1998 were identified. Patient characteristics, surgical, pathologic, and follow-up data were extracted and survival curves were generated. Results Forty-eight obese women were identified who were explored for radical hysterectomy and pelvic lymph node dissection. The median BMI was 36 kg/m2, and the median weight was 95 kg. Thirty-five patients (73%) had stage Ib1 disease. Despite the obesity of the study group, none had severe comorbidity. The procedure was completed in 46 patients, and abandoned in two because of metastatic disease. For patients undergoing radical hysterectomy and pelvic lymph node dissection, median blood loss was 800 mL. No patient developed fistulas. Residual tumor was present in 26 (57%) hysterectomy specimens, and margins were without disease in 45 specimens (98%). A median of 26 pelvic lymph nodes were obtained per procedure, and six patients (13%) had positive nodes. Five-year overall and disease-free survival are 84% (95% confidence interval [CI] 70.9, 97.5) and 80% (95% CI 65.2, 93.8), respectively, at a median follow-up of 36 months. Conclusion In this carefully selected obese group, we demonstrate that radical hysterectomy and pelvic lymph node dissection can be performed with adequate surgical resection, acceptable morbidity, and excellent survival. In carefully selected obese women, radical hysterectomy can be performed with adequate surgical resection, acceptable morbidity, and excellent survival.