gebhart/patrepeval huggingface dataset:
2D Active Antenna Array Design for FD-MIMO System and Antenna Virtualization Techniques (2015)

Full dimension MIMO (FD-MIMO) is one of the key technologies presently studied in the 3GPP for the next generation long-term evolution advanced (LTE-A) systems. By incorporating FD-MIMO into LTE/LTE-A systems, it is expected that system throughput will be drastically improved beyond what is possible in conventional LTE systems. This paper presets details on the 2D active antenna array design for FD-MIMO systems supporting 32 antenna elements. The FD-MIMO system allows for dynamic and adaptive precoding to be performed jointly across all antennas thus achieving more directional transmissions in the azimuth and elevation domains simultaneously, to a larger number of users. Finally, we discuss 2D antenna array port virtualization techniques for creating beams with wide coverage, necessary for broadcasting signals to all users within a sector, such as the CRS (Common Reference Signal).
Radially Inhomogeneous Spherical Dielectric Lens for Matching 100-ps Pulses Into Biological Targets (2010)

Design, simulations, and experiments on a radially inhomogeneous spherical dielectric lens, that is used at the second focal point of a prolate-spheroidal impulse radiating antenna, are presented. This lens is designed to match 100-ps pulses into a biological medium. The higher field amplitude and smaller spot size obtained with such a lens are useful for various bioelectric applications.
Principles for Modeling, Verification, and Simulation of Hybrid Dynamics Systems (1997)

Hybrid systems combine piecewise continuous behavior with discrete transitions. Hybrid dynamic systems extend this behavior with the notion of time to model the behavior of dynamic physical systems. Physical systems obey the principles of conservation of energy and continuity of power, and combine phenomena that occur at different time scales (i.e., fast and slow). At any specified level of interest, continuous system behavior can be abstracted, so that behavior appears to have discontinuous changes that intersperse modes of continuous behavior. Mode changes occur when system variables cross threshold values, and state events or external control events occur.
Collagen VI at a glance (2015)

Collagen VI represents a remarkable extracellular matrix molecule, and in the past few years, studies of this molecule have revealed its involvement in a wide range of tissues and pathological conditions. In addition to its complex multi-step pathway of biosynthesis and assembly that leads to the formation of a characteristic and distinctive network of beaded microfilaments in the extracellular matrix, collagen VI exerts several key roles in different tissues. These range from unique biomechanical roles to cytoprotective functions in different cells, including myofibers, chondrocytes, neurons, fibroblasts and cardiomyocytes. Indeed, collagen VI has been shown to exert a surprisingly broad range of cytoprotective effects, which include counteracting apoptosis and oxidative damage, favoring tumor growth and progression, regulating autophagy and cell differentiation, and even contributing to the maintenance of stemness. In this Cell Science at a Glance article and the accompanying poster, we present the current knowledge of collagen VI, and in particular, discuss its relevance in stemness and in preserving the mechanical properties of tissues, as well as its links with human disorders.
Aircraft-navigation-grade laser-driven FOG with Gaussian-noise phase modulation (2017)

A laser-driven fiber optic gyroscope (FOG) is demonstrated with an angular random walk noise of 5.5×10<sup>-4</sup> deg/√h, a drift of 6.8×10<sup>-3</sup> deg/h, and an inferred scale-factor stability of 0.15 ppm, making it, to the best of our knowledge, the first laser-driven FOG to satisfy the performance requirements for inertial navigation of commercial aircraft. This is achieved using Gaussian white noise phase modulation to broaden the linewidth of the source laser and to strongly suppress the narrow-linewidth optical carrier. The performance of this laser-driven FOG is shown to have better noise and only slightly higher drift than the same FOG driven by a conventional superfluorescent fiber source. This result is validated for two lasers with widely different intrinsic coherence.
Secure communication via untrusted switchable decode-and-forward relay (2017)

In this paper, a practical power efficient technique is proposed for an untrusted decode-and-forward (DAF) based cooperative communication system to provide secure communication between the source and the destination. More specifically, a DAF relay, called switchable DAF (sDAF), is designed in such a way that it can be switched to amplify-and-forward (AAF) in certain predefined situations. The algorithm is based on destination-assisted jamming and comprised of two phases. The first phase securely shares the random manipulating sequence (RMS) through an untrusted relay, while the second phase uses this RMS for secure communication through untrusted relay. This algorithm not only provides secrecy, but also enhances the power efficiency as compared to other destination-assisted jamming techniques.
Defense Automated Neurobehavioral Assessment (DANA)—Psychometric Properties of a New Field-Deployable Neurocognitive Assessment Tool (2013)

The Defense Automated Neurobehavioral Assessment (DANA) is a new neurocognitive assessment tool that includes a library of standardized cognitive and psychological assessments, with three versions that range from a brief 5-minute screen to a 45-minute complete assessment. DANA is written using the Android open-source operating system and is suitable for multiple mobile platforms. This article presents testing of DANA by 224 active duty U.S. service members in five operationally relevant environments (desert, jungle, mountain, arctic, and shipboard). DANA was found to be a reliable instrument and compared favorably to other computer-based neurocognitive assessments. Implications for using DANA in far-forward military settings are discussed.
Interplay of the adsorption of light and heavy paraffins in hydroisomerization over H-beta zeolite (2019)

Hydroisomerization: controlling selectivity by tuning the Pt/zeolite properties.
Supplementary Table 1 from A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer (2023)

Supplementary Table 1 from A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer
Back Cover: Quantitative Determination and Comparison of the Surface Binding of Phosphonic Acid, Carboxylic Acid, and Catechol Ligands on TiO2 Nanoparticles (Chem. Eur. J. 38/2016) (2016)

A systematic investigation of wet-chemical adsorption, desorption, co-adsorption, and exchange behavior of phosphonic acid, carboxylic acid and catechol monolayers on the surface of titanium oxide nanoparticles is presented. The reported procedure provides a toolbox to identify optimal monolayer–surface combinations and to evaluate critical parameters, such as monolayer robustness, ligand exchange rates, or targeted mixed assembly of functionalities, and should be applicable to many other colloidal metal oxide materials. More information can be found in the Full Paper by A. Hirsch et al. on page 13506 ff.
Compact receiver module for a 94 GHz band passive millimetre-wave imager (2008)

A compact receiver module for a 94 GHz band passive millimetre-wave (PMMW) imaging system is developed. This receiver module consists of an antipodal linearly tapered slot antenna (LTSA) and microwave monolithic integrated circuit (MMIC) with flip-chip bonding assembly that provides high radio frequency (RF) performance at low cost. A new microstrip-slot transition developed for the LTSA/MMIC interface is also presented and the design procedure for the LTSA is discussed, which obtains almost the same E- and H-plane beam widths. In addition, a low-noise, high-gain MMIC is discussed using inverted microstrip lines that are developed. Finally, it is shown that the PMMW imager can generate a millimetre-wave image.
Synthesis and Utilization of Nitroalkyne Equivalents in Batch and Continuous Flow (2017)

Abstract We report a method for overcoming the low stability of nitroalkynes through the development of nitrated vinyl silyltriflate equivalents. Because of their instability, nitroalkynes have only rarely been utilized in synthesis. The reactivity of these silyltriflates, which are prepared in situ, is exemplified by dipolar cycloaddition reactions with nitrones to give highly substituted 4‐nitro‐4‐isoxazolines in high yields. This approach has proven general for several different alkyl and aryl substituted alkynes. In order to minimize the accumulation of potentially hazardous reaction intermediates, we have also developed a continuous flow variant of this method that is capable of carrying out the entire reaction sequence in a good yield and a short residence time.
Simplified methods of reasoning in fuzzy models (2002)

An obvious reason for the success of the Mamdani method of reasoning was that this method was efficiently simplified. However, it is widely known that the Mamdani method has one major drawback-it cannot work when the partitioning of the input space is not complete, i.e. some gaps in the rule-base exist. This is the reason that one of the basic requirement in fuzzy modeling is the complete partitioning of the input space by the antecedent fuzzy sets. An alternative solution to this problem is simply to replace the Mamdani method by the so-called logical method; but it has one major drawback it requires more calculations and there is no analytical description of the input-output relationship presented by the fuzzy model. Consequently this method is not suitable for learning. In this paper we show that the logical method can be significantly simplified. The result is a new reasoning method that is characterized with an analytical input-output description; in addition, its computational complexity is comparable to this of the Mamdani method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Final Results of a Phase I Study of the Histone Deacetylase Inhibitor Vorinostat (Suberoyanilide Hydroxamic Acid, SAHA), in Patients with Leukemia and Myelodysplastic Syndrome. (2005)

Abstract Vorinostat, formerly known as suberoyl anilide hydroxamic acid, (SAHA) is a histone deacetylase inhibitor with potent in vitro antileukemia activity. We conducted a phase I study of two dose schedules of vorinostat: oral three times a day (TID) x 14 days every 21 days; or oral twice a day (BID) x 14 days every 21 days. Patients with relapsed or refractory chronic and acute leukemia or myelodysplastic syndrome (MDS), with adequate renal, hepatic functions and performance status were eligible. Older patients with untreated AML/MDS were also eligible. Forty-one patients were registered and dosed. Median age was 54 years (range 18 to 90), 31 (76%) had AML, 4 (10%) CLL, 3 (7%) MDS, 2 (5%) ALL and 1 (2%) CML. The median number of prior therapies was 2 (range 0–7). The starting dose of the oral TID schedule was 100 mg po TID and it was increased in 50 mg po steps using a 3+3 design. As these patients were thrombocytopenic at baseline due to their underlying disease, thrombocytopenia was not considered to be a dose-limiting toxicity. A dose of 300 mg po TID was considered above the maximally tolerated dose (MTD) with 2 out of 3 patients developing grade 3 toxicity (nausea, vomiting and diarrhea). Subsequently, 7 patients were treated at a dose of 300 mg po BID x 14 days every 21 days. Two patients developed gastrointestinal toxicity (typhlitis) in the setting of profound neutropenia, and the dose was reduced in the next 6 patients to 200 mg po BID x 14 days. No excess toxicity was observed at that dose level. Subsequently, 6 more patients were treated at a dose of 200 mg po TID x 14 days (The MTD of 250 mg po TID X 14 days could not be further evaluated as the 50 mg capsule was no longer available). Only one out 6 patients developed grade 3 toxicity (fatigue). More frequently observed toxicities, regardless of causality, were nausea, vomiting, diarrhea, anorexia, headache, fatigue, typhlitis, and dyspepsia that resolved upon cessation of therapy. Laboratory abnormalities included pancytopenia, hyperglycemia, hypokalemia, hypocalcemia and hypophosphatemia. Overall 9 patients (21%) had objective evidence of response: 1 CR, 2 CRp (CR criteria but no recovery of platelet counts), 1 partial response and 5 complete marrow responses (blasts less than 5%). All responses were observed in patients with AML, and 5 (41%) of these responses were observed at a dose of 200 mg po tid. Histone acetylation was observed in all patients at all dose levels. In summary, the MTD of oral vorinostat is either 200 mg po TID or 200 mg po BID x 14 days every 21 days in patients with leukemia. Significant activity was observed at a dose of 200 mg po TID x 14 days in patients with AML. This single agent activity warrants additional investigation of the role of vorinostat in the therapy of AML and may be guided by the development of informative biomarkers.
HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6 (2007)

Enhanced expression levels of integrin alphavbeta6 have been linked to more aggressive invasive carcinoma cell behavior and poorer clinical prognosis. However, how alphavbeta6 determines invasion and the dynamics of integrin alphavbeta6 regulation in tumor cells are poorly understood. We have identified the 35-kDa HS1-associated protein X-1 (HAX-1) protein as a novel binding partner of the beta6 cytoplasmic tail using a yeast two-hybrid screen. We show that alphavbeta6-dependent migration is blocked following small interfering RNA (siRNA)-mediated depletion of HAX-1 in oral squamous cell carcinoma cell lines. Using both siRNA and membrane-permeable peptides, we show that alphavbeta6-dependent migration and invasion require HAX-1 to bind directly to beta6 and thereby regulate clathrin-mediated endocytosis of alphavbeta6 integrins. Progression of oral cancer is associated with enhanced expression of alphavbeta6 and HAX-1 proteins in patient tissue. This report establishes that integrin endocytosis is required for alphavbeta6-dependent carcinoma cell motility and invasion and suggests that this process is an important mechanism in cancer progression.
Distributed field plate effects in split-gate trench MOSFETs (2023)

Fast electric transients can cause distributed effects inside trench MOSFETs possibly resulting in device failure. A new test structure to study those distributed effects, combined with a new Transmission-Line Pulse (TLP) setup, is presented. On-wafer TLP measurements are performed and combined with TCAD and SPICE simulations to predict the space and time evolution of the field plate potential during transients.
Synthesis of an LFA-1 Inhibitor (2010)

Inhibitors of lymphocyte function-associated antigen 1 (LFA-1) are potential drugs for the treatment of inflammatory and immune disorders. The concise and robust five-stage process depicted delivered the target LFA-1 inhibitor on a one metric ton scale in 53% overall yield.
Predicted Effects of Interfacial Roughness on the Behavior of Selected Ceramic Composites (1997)

Potential effects of interfacial roughness in ceramic composites were studied using a model that included the progressively increasing contribution of roughness with relative fiber/matrix displacement during debonding of the fiber/matrix interface. A parametric approach was used to study interfacial roughness in conjunction with other parameters such as the strength, radius, and volume fraction of the fiber. The progressive roughness contribution during initial fiber/matrix sliding caused a high effective coefficient of friction, as well as an increased clamping stress, which led to rapidly changing friction with increasing debond length. Calculated effects implied a potentially significant contribution to the behavior of real composite systems and the necessity for explicit consideration in the interpretation of experimental data to understand composite behavior correctly. In a tension test, the Poisson's contraction of the fiber may negate the effects of roughness, allowing an “effective constant shear stress” (tau) approximation. This was evaluated using a piecewise linear approximation to the progressive roughness model in an analysis of composite stress‐strain behavior; for the Nicalon/SiC system, the effective tau value was lower than the values that would be obtained from fiber pushout tests and/or matrix crack spacings.
Isolation distances for minimizing out‐crossing in spring wheat (2001)

Currently recommended isolation distances of 3 or 10 m for pedigreed seed production of spring wheat ( Triticum aestivum L.) may not be sufficient for cultivars with high out‐crossing (OC) rates. The detection of higher than expected OC rates in wheat has directed this research to reassess currently recommended minimum isolation distances. The objective of this study was to determine if increased isolation distances are needed for cultivars that exhibit higher than normal levels of out‐crossing. In each of 2 yr, OC rates were determined for four Canadian spring wheat cultivars at each of 15 distances (0–33 m) from a blue aleurone pollen source. Cultivars were grown in rows perpendicular to the pollinator block to the north, south, west, and east. Target rows were replicated four times within each direction. Out‐crossing in ‘Katepwa’ and ‘Biggar’ was not detected beyond 3 m. Cultivars ‘Roblin’ and ‘Oslo’ exhibited higher than normal OC at distances of up to 27 m. For Roblin and Oslo, an isolation distance of 30 m is recommended to mitigate OC‐derived off‐types in the subsequent generation of pedigreed seed.
Adaptive Prefetching on POWER7 (2014)

Hardware data prefetch engines are integral parts of many general purpose server-class microprocessors in the field today. Some prefetch engines allow users to change some of their parameters. But, the prefetcher is usually enabled in a default configuration during system bring-up, and dynamic reconfiguration of the prefetch engine is not an autonomic feature of current machines. Conceptually, however, it is easy to infer that commonly used prefetch algorithms---when applied in a fixed mode---will not help performance in many cases. In fact, they may actually degrade performance due to useless bus bandwidth consumption and cache pollution, which in turn, will also waste power. We present an adaptive prefetch scheme that dynamically modifies the prefetch settings in order to adapt to workloads' requirements. We use a commercial processor, namely the IBM POWER7 as a vehicle for our study. First we characterize---in terms of performance and power consumption---the prefetcher in that processor using microbenchmarks and SPEC CPU2006. We then present our adaptive prefetch mechanism showing performance improvements with respect to the default prefetch setting up to 2.7X and 1.3X for single-threaded and multiprogrammed workloads, respectively. Adaptive prefetching is also able to reduce power consumption in some cases. Finally, we also evaluate our mechanism with SPECjbb2005, improving both performance and power consumption.
On the Validity of Using Increases in 5-Year Survival Rates to Measure Success in the Fight against Cancer (2014)

We have demonstrated, via the negative correlation between changes in 5-year survival rates and changes in MOI, that increases in 5-year survival rates reflect real improvements over time made in the clinical management of cancer. Furthermore, we found that increases in 5-year survival rates are not predominantly artificial byproducts of lead-time bias, as implied in the literature. The survival measure alone can therefore be used for a rough approximation of the amount of progress in the clinical management of cancer, but should ideally be used with other measures.
Rupturing C60Molecules into Graphene-Oxide-like Quantum Dots: Structure, Photoluminescence, and Catalytic Application (2015)

The large-scale synthesis of graphene-oxide-like quantum dots (GOLQDs) is reported by oxidizing C(60) molecules using a modified Hummers method with a yield of ≈25 wt% readily achieved. The GOLQDs are highly soluble in water and in addition to hexagons have other carbon rings in the structure. They have an average height of ≈1.2 nm and a diameter distribution of 0.6-2.2 nm after drying on substrates. First-principle calculations indicate that a possible rupturing route may include the insertion of oxygen atoms to CC bonds in the C(60) molecule, followed by rupture of that CC bonds. The GOLQD suspension has a strong photoluminescence (PL) with peak position dependent on excitation wavelength. The PL is related to the size and emissive traps caused by oxygen-containing groups. The GOLQDs also catalyze the oxidation of benzyl alcohol with a high selectivity.
Additive ram material extrusion and diddling of fully compounded thermoset nitrile rubber (2021)

Abstract A ram extruder is described for high‐pressure extrusion of fully compounded thermoset rubber to achieve additive manufacturing. The extruder uses a piston driven by a geared stepper motor to provide volumetric displacement of the rubber charge residing in a temperature‐controlled barrel. Along with activators, accelerators, and a vulcanizing agent, the rubber compound is a formulation of 30 parts carbon black per hundred parts nitrile rubber. Sets of serpentine patterns are printed in parallel and transverse orientations relative to the load direction. From printing to post‐cure, the printed specimens exhibited linear shrinkage of 65% in the print direction. Although printed samples had relatively low void content compared with typical additively manufactured parts by material extrusion, significant decreases in the tensile properties were observed relative to compression‐molded specimens of the same rubber compound. The mean strain to failure was observed as 462% for compression‐molded samples, compared with 347% and 183% for printed specimens with parallel and transverse orientations. To reduce the shrinkage and increase the interfacial area between extruded roads, backstitch and sinewave diddling patterns were implemented to superimpose oscillatory motions along the print path with a periodicity of 1 mm. The specimens printed with the diddling patterns were observed to provide less shrinkage and improved properties compared to the regular serpentine patterns. The mean strain to failure in the transverse orientation, respectively, increased to 218% and 265% for the backstitch and sinewave patterns. Suggested future research is discussed, and the diddling program is provided in the appendix.
Supplementary Figures 1-4 from <i>In vivo</i> Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer (2023)

Supplementary Figures 1-4 from &lt;i&gt;In vivo&lt;/i&gt; Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer