gebhart/patrepeval huggingface dataset:
Mutations in the MECP2 gene in a cohort of girls with Rett syndrome (2000)

Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome EDITOR-Rett syndrome (RTT, MIM 312760) is a neurodevelopmental disorder characterised by normal early psychomotor development followed by a period of regression, the loss of acquired purposeful manual and speech skills, hand wringing, gait disturbance, and growth retardation. 1 As RTT occurs exclusively in females and almost all patients with RTT are sporadic, it has been proposed that RTT is caused by an X linked dominant mutation with lethality in hemizygous males. 1 Recently, DNA mutations in the methyl-CpG binding protein 2 gene (MECP2), mapped to Xq28, have been detected in some patients with RTT. 2 3 We carried out a mutation analysis in 40 Japanese patients with RTT to confirm that MECP2 is the gene responsible for RTT and to detect common mutations in MECP2.
Evaluating Viscosity of Surimi Paste at Different Moisture Contents (2004)

Abstract The steady and dynamic shear viscosity of fish muscle protein paste obtained from Alaska pollock surimi at 95%, 90%, 85%, 80%, and 75% of moisture contents were measured in the temperature range of 5°C to 20°C. To estimate the steady shear viscosity at high shear rate from dynamic shear viscosity, the modified Cox-Merz rule was applied by introducing a frequency shift factor. The concentration dependence of zero-shear viscosity showed power-law dependence with an exponent of 3.5, and the universal behavior of viscosity at different protein concentrations was observed by a introducing reduced variables. The Carreau model was applied to describe the shear- thinning behavior of the surimi paste, and the model parameters estimated empirically showed moisture content dependence. The viscous flow behavior was independent of temperature (5°C to 20°C), and addition of starch decreased the flow index and viscosity of the paste, compared to the pure surimi paste.
Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation (1991)

Calcitonin gene methylation at CCGG sites were determined in 39 chronic myeloid leukemia patients by isoschizomeric restriction endonuclease analysis. A total of 27 patients were analyzed while still in the chronic phase: 20 patients had a normal gene, and seven had a hypermethylated gene. There were 12 patients initially studied in accelerated or blastic phases. All but one patient showed gene hypermethylation, suggesting a good correlation between gene methylation and disease stage. All five patients who, while still in the chronic phase, had a major 3.1-kb hypermethylated calcitonin gene fragment, accelerated within 2 to 27 months. In consecutively analyzed patients, the initially normal calcitonin gene changed to a hypermethylated state as the disease escalated. The hypermethylation predicted disease acceleration with a median lead time of 6 months before any morphologic or clinical signs of disease progression were seen. The disease progressed in 8 of 27 patients initially studied in the chronic phase: in only two patients this occurred without predictive methylation changes. The results suggest that the assessment of calcitonin gene methylation status may be a promising tool for monitoring chronic myeloid leukemia disease escalation.
Spintorque Oscillator Characteristics in Coupled Networks (2010)

In this paper, the basic principle of the spintorque oscillator is presented. The output of the oscillator exhibits a very low power and an important level phase noise. In order to improve the output signal performance, a coupling approach is presented herein.
Modelling Airy beams propagation with lens design software (2010)

Airy beams are a new class of nondiffracting beams predicted in 1979 and observed in 2007. In this paper, we show that beam propagation methods are an effective way to study the behavior of those beams in propagation and to design such beams. A lens design software integrated beam propagation feature is implemented to design an Airy beam generation setup based on Fourier transform in a coherent optical system. The setup was reproduced in the lab for experimental validation using a "cubic-shaped" mirror. The resulting monochromatic Airy beam presents a main lobe FWHM of approximately 30 &mu;m over a diffraction-free distance of 15 mm. Computational results show excellent agreement with experimental data as well as with analytical predictions expressed in terms of the optical setup geometrical parameters.
Monitoring immune cells‐mediated cytolysis through impedance technology allows kinetic analysis of reagent efficacy (2018)

In vitro characterization of immunotherapy reagents efficacy and combination synergies is necessary before moving to expensive animal models and clinical studies. Current standard assays like Chromium‐51 release, ATP‐based luminescence cell monitoring or flow cytometry are difficult to implement in a high throughput environment and are based on end point methodologies that are unable to capture the full dynamic of the immune response. Here we validate an impedance‐based platform for monitoring cytotoxic activity of immune cells in the context of cancer immunotherapy assays. The technology detects cell death and proliferation of adherent cells by measuring changes in conductance of microelectrodes embedded in 96 and 384‐wells cell culture plates, without the use of labeling or cell modification. We present a large set of validation including CD19 Car T models, EpCAM/CD3 BiTE antibodies and checkpoint combination therapies with anti PD‐1/PD‐L1 and CTLA‐4 antibodies. Data comparison with Annexin V staining/Flow Cytometry shows perfect correlation between the drop in impedance signal and % of apoptotic cells. Long time monitoring (&gt; 7 days) in combination with low effector:target ratios reveal the occurrence of resistance mechanisms in target cells and exhaustion in effector cells. Such dynamic response has been observed in animal models and patient clinical trials, but it is difficult to monitor in short time assays. Overall, our results demonstrate the value of such label‐free approach in measuring the cytotoxic response across the temporal scale, an aspect that is otherwise very difficult to assess with more canonical end point assays but that is highly relevant when testing combinations. Thanks to the availability of 384‐wells format and minimal sample handling, the technology is ideally suited for applications in large reagent validation screening or therapeutic protocol validation directly on patient samples. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
ChemInform Abstract: An Efficient Synthesis of Large Ring Acetylenes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interleukin-6 and C-Reactive Protein Levels and 9-Year Cognitive Decline in Community-Dwelling Older Women: The Women’s Health and Aging Study II (2020)

Elevated inflammation is a proposed mechanism relating chronic diseases to cognitive dysfunction. The objective of this study was to test the hypothesis that greater levels of inflammation, as measured by the proinflammatory cytokine interleukin-6 (IL-6) and C-reactive protein, are associated with faster rates of cognitive decline among cognitively intact community-dwelling older women.
Activity-adaptive modeling of dynamic multimedia traffic (2002)

Most of the existing work on modeling variable bit rate (VBR) video sources does not either explicitly take into account group-of-pictures (GOP) or assumes a fixed GOP structure. Real video data inherently possesses a variable GOP structure. We propose a number of doubly Markov models for such real data. These models outperform presently proposed models and have reasonable complexity in terms of the number of parameters.
Kagome fiber based nonlinear pulse compression of 1.8 ps to 250 fs at 2.05 µm from Ho:YLF amplifier (2016)

International audience
Multiple thermoluminescence glow peaks and afterglow suppression in CsI:Tl co-doped with Eu2+or Yb2+ (2015)

CsI:Tl is a widely utilized scintillator material with many desirable properties but its applicability is limited by persistent afterglow. However, effective afterglow suppression has been achieved by co-doping with divalent lanthanides. The present report is concerned with observation of multiple thermoluminescence glow peaks in CsI:Tl,Eu and CsI:Tl,Yb, attributed to varying distributions of charge-compensating cation vacancies relative to divalent lanthanide co-dopants, and the subsequent modification of these distributions by repeated observations. It is observed that Yb2+ provides a slightly shallower electron trap than Eu2+, and that it can occupy a face-centered position by virtue of its relatively small ionic radius; the latter observation is confirmed by electrostatic calculations. It is also found that repeated observation of thermoluminescence in these materials has a modest adverse effect on afterglow suppression.
Renal radiosurgery: cautious optimism. (2013)

PONSKY LE. Renal radiosurgery: cautious optimism. Can J Urol 2013;20(5):6950. evaluation after treatment also needs to be assessed. We need to ensure radiographic response matches that of pathologic response. Our group agrees with the authors that radiosurgery with technologies such as the CyberKnife and others, may potentially offer such advantages. Although the current technique requires the percutaneous placement of a fiducial marker in or near the tumor to track the movement of the target, perhaps future technologies will not require this. It is critical that we continue to evaluate such new techniques and technologies and ensure as surgeons we are involved in the evaluation and defining the appropriate use of such technologies. It is important to point out, a partial nephrectomy or cryoablation that achieves ‘partial response’ is still considered a ‘failure’. We need to hold all techniques to the same standards of evaluation and definition of success or failure. Our group, as well as others, are completing dose escalation trials to appropriately define the ideal dose schedules that should be used to ensure an efficacy equivalent to a partial nephrectomy with less toxicity. We are cautiously optimistic with the authors work and look forward to continued critical evaluation of this exciting new direction. Nair and colleagues are to be commended for reporting the initial Canadian experience evaluating the use of the CyberKnife for inoperable renal tumors.1 Three patients were treated with radiosurgery, two of the patients had solitary kidneys and the third had prior radiofrequency ablation. The patients were treated with 39 Gy in 3 fractions. Mean tumor size was 21.3 cm3. Mean follow up was 13.3 months. The authors present no acute or chronic toxicities, unaffected renal function and local tumor control in all patients. In the follow up period two patients had stable disease and one had a partial response. While this is encouraging and this technique shows significant promise, we still need to be extremely critical of this approach to renal tumors. Uzzo’s group have previously described that the average growth rate of an untreated renal mass is approximately 0.28 cm/year with progression to metastatic disease occurring approximately 1% during follow up. Twenty-six percent to 33% of renal tumors have also been shown to have no growth over a 29 month median follow up.2,3 The challenge with treating renal tumors is that the bar is set high regarding safety and efficacy. Minimally invasive approaches including radiofrequency ablation, cryoablation, laparoscopic and robotic partial nephrectomy, and now in appropriately selected patients, active surveillance have been shown to be good options for patients with small renal masses. There is no question that there is a role for a new non-invasive ablative technology that does not require anesthesia, such as radiosurgery, to treat renal tumors. However, such a technology needs to achieve at the least the same efficacy of the current treatment options with the additional advantage of being less invasive and less morbidity. Pathologic References
Solvent-resistant polyetherimide network systems via phenylethynylphthalic anhydride endcapping (1994)

The synthesis and characterization of a highly processable thermosetting polyimide system based on 22'-bis[4-(3,4-dicarboxyphenoxy)phenyl]propane dianhydride or bisphenol A dianhydride (BPA-DA) endcapped with 4-phenylethynylphthalic anhydride is described. The system afforded oligomers that were readily melt processable at high curing temperatures (380-420 CC). Imide oligomers ranging from MR = 2000 to 40 000 g molI and copolyimides were synthesized using the ester acid of the dianhydrides and either meta- and/or para-phenylene diamines as comonomers via solution imidization techniques. The oligomers were shown to display low melt viscosity values and to flow under low pressure during compression moulding. The thermally cured polymers formed tough creasable films and displayed excellent solvent resistance which was correlated to their high gel fractions (&gt;95%). Very significant increases in glass transition temperatures were observed after cure of a 3000., oligomer. The mera-phenylene diamine-based polymer exhibited a cured T s approximately 30C lower (233C) than the para:meta (70:30) system (267C). The all para-phenylene diamine-based homopolymers could be completely cyclized in solution but crystallized at room temperature to produce fine insoluble powders. The resulting moderately semicrystalline homopolymer showed a TM of up to 321 'C which was not observed on the second heating. These polyimides also show excellent thermal stability as judged by thermogravimetric analysis (TGA) and are being examined as structural adhesives and matrix resins.
A Review of Wireless and PLC Propagation Channel Characteristics for Smart Grid Environments (2011)

Wireless, power line communication (PLC), fiber optic, Ethernet, and so forth are among the communication technologies on which smart grid communication infrastructure is envisioned to be built. Among these, wireless and PLC-based solutions are attractive considering the cost of initial deployment. Wireless communication deployment in smart grid covers a variety of environments such as indoor, outdoor, and electric-power-system facilities. Similar diversity is expected in PLC deployment as well covering low voltage (LV), medium voltage (MV), and high voltage (HV) segments of the grid. In spite of being attractive, wireless and PLC channels are very harsh posing great challenges to performance of communication systems. In proposing solutions to smart grid communication needs, two approaches are likely to be followed. One is based on the use of existing wireless and PLC technologies with some modifications, and the other relies upon developing novel communication protocols particularly addressing the smart grid needs. Both of these approaches require an in-depth knowledge of communication channel characteristics. The aim of this study is to reveal the wireless and PLC channel characteristics of smart grid environments in terms of several parameters such as path loss and attenuation, time dispersion, time selectivity, amplitude statistics, and noise characteristics.
Abstract 2667: In vitro properties and pre-clinical activity of PF-06801591, a high-affinity engineered anti-human PD-1 (2017)

Abstract Monoclonal-antibody-based therapies targeting the immune checkpoint receptors have become the new standard of care in many cancers. Antibodies that specifically target programmed death receptor-1 (PD-1) or its cognate ligand, programmed death receptor ligand-1 (PD-L1), alone or in combination, have yielded clinical benefits and durable responses in patient subsets with various cancers (including metastatic melanoma, NSCLC, RCC, urothelial cancer, cHL and others). Here we report on the biophysical characteristics and non-clinical antagonistic activities of PF-06801591. PF-06801591 is a humanized anti-PD-1 antibody of human IgG4 isotype, that binds selectively and with similar potency to human and cynomolgus monkey PD-1 receptor (EC50 ~50 pM) and blocks its interaction with its cognate ligands PD-L1 and PD-L2 (IC50 &amp;lt; 1 nM) with no detectable Fc effector function. The interaction of PF-06801591 to PD-1 rescues T cell suppression and exhaustion that translates into NFAT activation, IL-2 and IFN-gamma secretion and T cell proliferation both in vitro cultures and in vivo using an acute xeno GvHD model with human PBMC transfer. Binding of PF-068001591 to human and cynomolgus PD-1 is characterized by the formation of a very stable complex (T1/2 = 2 h) as measured by SPR at 37 C, resulting in high affinity (KD ~20 pM) as measured in solution by KinExA at 23 C. In addition, we explored therapeutic potential of anti-PD-1 in combination with other immunotherapy agents using surrogate antibodies in non-clinical tumor models. The data presented here support future development of PF-06801591 as a single agent or in combination with other immunotherapies. Citation Format: Sawsan Youssef, Yasmina Abdiche, HoangKim Nguyen, Joyce Chou, Sherman Michael Chin, Cris Kamperschroer, Patricia A. Schneider, Eugenia Kraynov, Heike I. Krupka, Arvind Rajpal, John Lin. In vitro properties and pre-clinical activity of PF-06801591, a high-affinity engineered anti-human PD-1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2667. doi:10.1158/1538-7445.AM2017-2667
Performance Trial-Test of the Full-Scale Driving Pump for the Large Cavitation Tunnel(LCT) (2015)

The objective of the present study is to analyze the results of the trial-test for the full-scale driving pump, which is arranged in the LCT (Large Cavitation Tunnel). Firstly, the reasons of selecting the final design pump are introduced in terms of the performance analysis in model tests. The trial-test items for the full-scale driving pump are measurements of output current/voltage at the inverter of the main motor and the flow velocity in the LCT test section. The test results show the increase in flow rate of about 10.7% and the decrease in pump head of about 26%, compared with those of final design-pump specification. The motor power has the margin of about 22%. The performance analysis for the full-scale pump is conducted using the commercial code (CFX-10). The delivered power calculated with CFX-10 shows good agreement with that extracted from the full-scale pump test. It is found that CFX-10 is useful to analyze a full-scale pump.
No-go theorem for passive single-rail linear optical quantum computing (2011)

Photonic quantum systems are among the most promising architectures for quantum computers. It is well known that for dual-rail photons effective non-linearities and near-deterministic non-trivial two-qubit gates can be achieved via the measurement process and by introducing ancillary photons. While in principle this opens a legitimate path to scalable linear optical quantum computing, the technical requirements are still very challenging and thus other optical encodings are being actively investigated. One of the alternatives is to use single-rail encoded photons, where entangled states can be deterministically generated. Here we prove that even for such systems universal optical quantum computing using only passive optical elements such as beam splitters and phase shifters is not possible. This no-go theorem proves that photon bunching cannot be passively suppressed even when extra ancilla modes and arbitrary number of photons are used. Our result provides useful guidance for the design of optical quantum computers.
Role of IL-33 signaling in pollutant-induced allergic airway inflammation (2018)

<b>Background:</b> Clinical and experimental studies have demonstrated an important role for IL-33 and its receptor ST2 in allergic asthma. Inhalation of traffic-related pollutants, such as diesel exhaust particles (DEP), facilitates the development of asthma and can cause exacerbations of asthma. However, it is unknown whether IL-33/ST2 signaling contributes to the enhancing effects of air pollutants on allergic airway responses. <b>Aims:</b> To investigate the functional role of IL-33/ST2 signaling in DEP-enhanced allergic airway responses, using an established murine model of combined DEP and allergen exposure. <b>Methods:</b> C57BL/6J mice were exposed to saline, DEP alone, house dust mite (HDM) alone, or combined DEP+HDM. To inhibit IL-33 signaling, recombinant soluble ST2 (r-sST2) was given prophylactically (i.e. during the whole experimental protocol) or therapeutically (i.e. at the end of the experimental protocol). Airway hyperresponsiveness and the airway inflammatory responses were assessed in bronchoalveolar lavage fluid (BALF) and lung. <b>Results:</b> Combined exposure to DEP+HDM increased IL-33 and ST2 expression in lung, elevated inflammatory responses and bronchial hyperresponsiveness compared to saline, sole DEP or sole HDM exposure. Prophylactic interference with the IL-33/ST2 signaling pathway impaired the DEP-enhanced allergic airway inflammation in the BALF, whereas effects on lung inflammation and airway hyperresponsiveness were minimal. Treatment with r-sST2 at the end of the experimental protocol did not modulate the DEP-enhanced allergic airway responses. <b>Conclusion:</b> Our data suggest that the IL-33/ST2 pathway contributes to the onset of DEP-enhanced allergic airway inflammation.
Role of IL‐6 in a novel murine model of transient ischemic attack (853.1) (2014)

TIA is a precursor event in 7‐40% of patients who suffer from an ischemic stroke. This study involves the development of a murine model of TIA and explores the mechanism that accounts for the increased vulnerability of cerebral arterioles to thrombus development after TIA. TIA was simulated by brief (2.5 ‐ 10 min) occlusion of the middle cerebral artery. Thrombus formation in cerebral arterioles (induced by light/dye photoactivation of FITC‐dextran) was evaluated 1 ‐ 28 days after the TIA. Thrombosis was quantified using time of onset of platelet aggregation on the vessel wall and the time to complete flow cessation. While the brief period of TIA was not associated with neurological deficits or brain infarction (evaluated after 1 day), it yielded a pronounced and prolonged (up to 28 days) acceleration of thrombus formation, compared to control (sham) mice. Either immunoblockade of the interleukin‐6 (IL‐6) receptor or genetic deficiency of IL‐6, but not IL‐6‐/‐ bone marrow chimeras, signficantly protected against the TIA induced enhancement of thrombosis. Our findings indicate that the increased vulnerability of the cerebral vasculature to thrombus development after TIA can be recapitulated in a murine model, and that IL‐6, likely derived from brain tissue, rather than circulating immune cells, is an important mediator of, and possible therapeutic target for, TIA‐induced thrombogenesis. Grant Funding Source : HL26441