gebhart/patrepeval huggingface dataset:
Pathogenesis of Influenza A(H7N9) Virus in Aged Nonhuman Primates (2020)

The avian influenza A(H7N9) virus has caused high mortality rates in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In the current study, we used nonhuman primates to evaluate the effect of aging on the pathogenicity of A(H7N9) virus. We observed that A(H7N9) virus infection of aged animals (defined as age 20-26 years) caused more severe symptoms than infection of young animals (defined as age 2-3 years). In aged animals, lung inflammation was weak and virus infection was sustained. Although cytokine and chemokine expression in the lungs of most aged animals was lower than that in the lungs of young animals, 1 aged animal showed severe symptoms and dysregulated proinflammatory cytokine and chemokine production. These results suggest that attenuated or dysregulated immune responses in aged animals are responsible for the severe symptoms observed among elderly patients infected with A(H7N9) virus.
Advanced components and sub-system solutions for 40 Gb/s transmission (2002)

With the commissioning of the latest 10-Gb/s systems, vendors are now in the process of developing architectures for their next-generation products. 40-Gb/s components and subsystems are currently in development to address the necessities of these next-generation systems. The top three challenges associated with 40-Gb/s transmission are optical signal-to-noise ratio, dispersion, and high-speed components. In order to realize 40-Gb/s transmission, new component and subsystem developments are crucial. This paper reviews the latest transmission technologies and dispersion compensation techniques developed to fulfill 40-Gb/s transmission system requirements.
Electrochemistry and Microelectronics, Perspective and Prospective (2021)

Abstract Modern electrochemistry contributes significantly to the field of Micro‐System‐Technologies (MST). MST is the base of the global information and communication technology (ICT) driving most aspects of modern life. MST includes Micro and Nano scale manufacturing disciplines such as microelectronics, micro electro mechanical systems, micro‐electro‐optics, microfluidics and more. MST, since its conception, involved many aspects of applied electrochemistry: process modules (i. e. deposition, etching, cleaning etc.), devices (i. e. biosensing, chemical sensing etc.), and energy components (i. e. sources, energy harvesting, storage etc.). We present a brief historical overview, followed by a discussion about the main topic of this work, electrochemistry and MST. To highlight the electrochemistry contribution, two examples are presented demonstrating when electrochemistry provided critical micro technologies. The first is Very Large‐Scale Integration copper metallization, which is already in mass production, and the second is 3D integration of circuits and systems, which is under intense research and development.
Discussion on common functionalities according to service classification in Y.NGN-Web (2010)

At the last NGN-GSI meeting on January 2010, we had discussed NGN architecture with web service component in Y.NGN-Web (Functional Requirements and Architecture of Web Service Component in NGN). In particular, several issues on common functionalities had been raised at the joint session with Q5. Accordingly, the related editor's note had been included in the Section 7.2 of Y.NGN-Web. So, this contribution discusses further study issues for common functionalities for service control according to service classification.
Dimmable Solid State Ballast With Integral Capacitive Occupancy Sensor (2011)

This paper describes and demonstrates an LED lighting system with an integral capacitive sensor that can detect occupancy both lighted and in the dark, and a driver (“ballast”) that is dimmable over a wide range. Sensing in the dark is accomplished by taking advantage of the logarithmic relationship between LED voltage and current. The ballast uses an inductor pre-charge technique to maintain efficiency during dimming, while maintaining relevant parameters for quality of lighting (e.g., chromaticity/color cast).
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial (2021)

Treatment was well tolerated. The rapid expansion of UV1-specific Th1 cells in the majority of patients indicates synergy between UV1 vaccine and CTLA-4 blockade. This may have translated into clinical benefit, encouraging the combination of UV1 vaccination with standard of care treatment regimes containing ipilimumab/CTLA-4 blocking antibodies.
Secure Video Player for Mobile Devices Integrating a Watermarking-based Tracing Mechanism (2014)

Content protection relies on several security mechanisms: (i) encryption to prevent access to the content during transport, (ii) trusted computation environment to prevent access during decoding, and we can also add (iii) forensic watermarking to deter content re-acquisition at rendering. With the advent of next generation video and the ever increasing popularity of embedded devices for content consumption, there is a need for new content protection solutions that rely less on hardware. In this context, we propose an architecture that combines the ARM TrustZone technology, an hypervised environment built on Genode and a bit stream watermarking algorithm that inserts serialization marks on the fly in an embedded device. As a result, an attacker cannot get access to video assets in clear form and not watermarked. Reported performances measurements indicate that the induced computational overhead is reasonable.
PDMS/MWCNT nanocomposite actuators using silicone functionalized multiwalled carbon nanotubes via nitrene chemistry (2013)

We demonstrate that covalently functionalized multiwalled carbon nanotubes (MWCNT) with a silicone copolymer via nitrene chemistry can be used as efficient conductive fillers for silicone dielectric elastomer actuators. The MWCNTs were covalently functionalized with poly(azidopropylmethyl)-co-(dimethylsiloxane) (silicone-N3) bearing an azide group through a nitrene addition reaction. The incorporation of a small amount of the uniformly silicone grafted MWCNTs (silicone-g-MWCNTs) in silicone dielectric elastomer strongly enhanced the mechanical, dielectric, and electromechanical properties of the resulting nanocomposites. This reinforcing effect is attributed to the homogeneous dispersion of silicone-g-MWCNTs in the silicone elastomer matrix due to the large degree of compatibility between the matrix and the passivation layers of the functionalized MWCNT.
Learning non-holonomic object models for mobile manipulation (2015)

For a mobile manipulator to interact with large everyday objects, such as office tables, it is often important to have dynamic models of these objects. However, as it is infeasible to provide the robot with models for every possible object it may encounter, it is desirable that the robot can identify common object models autonomously. Existing methods for addressing this challenge are limited by being either purely kinematic, or inefficient due to a lack of physical structure. In this paper, we present a physics-based method for estimating the dynamics of common non-holonomic objects using a mobile manipulator, and demonstrate its efficiency compared to existing approaches.
Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle (2014)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Anti-programmed cell death protein 1 (anti-PD1) immunotherapy induced autoimmune polyendocrine syndrome type II (APS-2): a case report and review of the literature (2019)

This is the first report of the full triad of APS-2 developing in a genetically susceptible individual at the age of 78 after treatment with an anti-PD1 agent. Although scarcely reported, a literature review of similar reports seems to indicate a predilection for this syndrome in patients with HLA-DR4 serotypes. HLA Class II typing is not routinely recommended, but may provide useful predictive information for patients at risk of poly-endocrinopathy even in patients without a relevant personal or family history. Additional studies are required to determine if such testing would be useful and/or cost effective.
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody blockade in patients previously vaccinated with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF) (2004)

2536 Background: Vaccination with irradiated, autologous tumor cells engineered to secrete GM-CSF (GVAX) consistently stimulates anti-tumor immune responses, but most patients eventually succumb to progressive disease. Mechanisms to augment the potency of vaccination are required. The attenuation of T cell activation by CTLA-4 represents one potential limitation. In a pilot study of patients previously treated with a variety of vaccination strategies, treatment with a CTLA-4 blocking antibody (MDX-010) induced extensive tumor destruction with lymphocyte and granulocyte infiltrates in 3 of 3 melanoma patients and the reduction or stabilization of CA-125 levels in 2 of 2 ovarian carcinoma patients who previously received GVAX. Methods: We recently undertook a phase I study administering MDX-010 to metastatic melanoma, NSCLC, ovarian cancer, and AML/MDS patients previously immunized with GVAX. Eligibility required measurable disease, no standard curative options, adequate end organ function, and no autoimmune disease requiring immunosuppressive treatment. Patients receive a 3 mg/kg infusion of MDX-010, with repeat dosing possible every 2 months. Results: An additional 2 ovarian patients and one AML patient have been treated to date. One ovarian patient has stable disease; the second had a dramatic reduction in CA-125 from 3478 to 145 with tumor regression after a single dose of MDX-010. No significant toxicities including autoimmune were observed. The trial will accrue 48 patients. Conclusions: CTLA-4 antibody blockade augments effective anti-tumor immunity without inducing autoimmunity in patients previously vaccinated with GVAX. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Medarex, Inc. Medarex, Inc. Cell Genesys; Medarex, Inc.
Aluminum-Exchanged Sepiolite as a Component of Fluid Cracking Catalysts (1991)

Sepiolite has been made exchangable by chemical treatments and Mg2+ at the border of the channels has been substituted by Al3+. In this way sepiolite with mild acidity, controlled mesopore, and improved stability has been obtained. This material is active for gasoil cracking, giving a good bottom conversion, and light cycle oil products without excessive gas and coke formation. Meanwhile, it is active for vanadium passivation.
Downstaging of localized prostate cancer by neoadjuvant therapy with flutamide and lupron: the first controlled and randomized trial. (1993)

Although the only opportunity to cure prostate cancer is treatment at an early stage, radical prostatectomy has remained relatively unpopular because 40-50% of prostate cancers estimated at diagnosis as confined to the prostate are found to be at a more advanced stage following histopathological analysis of the surgical specimen. This first prospective, randomized trial investigated the potential advantages of 3-month neoadjuvant combination therapy with flutamide and lupron before radical prostatectomy vs. prostatectomy alone in early stage prostate cancer. Cancer-positive margins were reduced from 38.5% (25 of 65) in control patients to only 13.0% (10 of 77) in men who received neoadjuvant combination therapy with the antiandrogen flutamide and the luteinizing hormone-releasing hormone (LHRH) super-agonist Lupron before radical prostatectomy (p = 0.006). Moreover, comparison of the final stage determined by histopathological examination of the surgical specimen with that estimated at diagnosis showed that a more advanced stage (upstaging) was found in 53.8% of controls, but patients who received combination therapy had an opposite effect: a more favorable stage than expected at diagnosis was found in 23.4% of cases (downstaging), a 77.2% advantage of neoadjuvant combination therapy. The concern about radical prostatectomy, underestimation of stage, is thus markedly improved by 3-month neoadjuvant therapy with flutamide and a LHRH superagonist. Cancer-negative margins are expected to be accompanied by a life expectancy not different from that of men of similar age with no prostate cancer; therefore, the present data, combined with efficient detection of early stage prostate cancer, offer the basis for dramatic improvement in the morbidity and mortality of prostate cancer.
SYNTHESIS AND PROPERTIES OF AZULENE-SUBSTITUTED THIOPHENES, TERTHIOPHENES AND DITHIENOTHIOPHENES (2012)

Bis(azulenylethynyl)thiophenes, terthiophenes, and dithienothiophenes have been synthesized by the Pd-catalyzed cross-coupling of the corresponding diiodothiophenes with 1-and 6-ethynylazulenes under Sonogashira-Hagihara conditions.HETEROCYCLES, Vol.86, No. 1, 2012 oligomers provided effective optical band gap control and on/off fluorescence switching.In 2012, Nakayama and co-workers have reported di(2-azulenyl)-2,2'-bithiophene and -thieno[3,2-b]thiophenewhich showed OFET characteristics with high carrier mobilities of up to 5.0 × 10 -2 cm 2 /Vs. 8These systems exhibited an edge-to-face orientation in a well-defined herringbone packing in the crystalline state.Since 2-azulenyl group acts as neither electron-donating nor electron-withdrawing groups, the electronic contribution for bithiophene and thienothiophene should be smaller than the substitution at the other positions.We report herein the synthesis of di(1-and 6-azulenylethynyl)thiophenes, terthiophenes and dithienothiophenes by Sonogashira-Hagihara coupling reaction. RESULTS AND DISCUSSIONKey building blocks have been prepared according to the literature procedures to achieve the synthesis of desired azulene-thiophene derivatives.3,4-Di-n-butyl-2,5-diiodothiophene (1) was prepared by Kumada-Tamao-Corriu coupling of 3,4-dibromothiophene in the presence of Ni(dppp)Cl 2 and the treatment with I 2 and HgO. 9 3',4'-Di-n-butyl-2,2':5',2"-terthiophene 10 and dithieno[3,2-b:2',3'-d]thiophene 11 were prepared according to the literature procedures.The subsequent reactions with NIS afforded the corresponding diiodoterthiophene 2 and diiododithienothiophene 3, respectively.Sonogashira-Hagihara coupling of diethyl 6-bromoazulene-1,3-dicarboxylate 12 and TMSA followed by removal of trimethylsilyl group with TBAF gave 6-ethynylazulene 4. 13 Synthesis of di(6-azulenylethynyl)thiophenes 6-8 are summarized in Scheme 1 and Figure 1.Sonogashira-Hagihara coupling reactions of 1 and 2 with 4 afforded di(6-azulenylethynyl)thiophene 6 and terthiophene 7 in 71% and 84% yields, respectively.Although Pd(0)-catalyzed coupling of 3 with 4 afforded the desired product, the pure product could not be isolated due to the low solubility in common organic solvent.Thus, preparation of di(6-azulenylethynyl)dithienothiophene with hexyloxycarbonyl substituents at 1,3-positions in azulene was carried out.Dihexyl 6-ethynylazulene-1,3-dicarboxylate (5) was prepared by transesterification of diethyl 6-bromoazulene-1,3-dicarboxylate with 1-hexanol, Sonogashira-Hagihara coupling with TMSA, and detrimethylsilylation with KF. 13 The cross-coupling of 3 with 5 in the presence of Pd(0) catalyst gave the bisadduct 8 in 80% yield.
Abstract 387: Individual Biochemical Characterization of the Renin-Angiotensin-System by RAS-Fingerprinting in Healthy Volunteers Treated with RAS-Blockers (2012)

The Renin-Angiotensin-System (RAS) is critically involved in the regulation of important physiological functions including blood pressure and fluid balance. It is constituted by multiple enzymes giving rise to a meshwork of effector peptides, which mediate their functions through binding to specific receptor molecules. Therefore, the modification of angiotensin peptide levels represents a common strategy for the treatment of RAS-associated diseases and is frequently achieved by the pharmacologic regulation of enzymes taking part in angiotensin metabolism. We developed a highly sensitive method, which allows the simultaneous absolute quantification of up to 10 different angiotensin peptides in human plasma and whole blood (RAS-Fingerprinting). The measurement of RAS-Fingerprints provides unique insights into the physiology of the human RAS and therefore represents a powerful tool for the patient specific evaluation of this physiologically important peptide hormone system. Beside the precise quantification of angiotensin peptides in plasma and whole blood, RAS-Fingerprints analyze the biochemical hardware of the RAS at a previously unachieved level of detail and accuracy. During the development and validation of our LC-MS/MS based method, comprehensive datasets showing multiple applications for RAS-Fingerprinting have been generated. Investigation of healthy volunteers revealed that a patient specific state of the RAS exists, which is defined by a unique composition of RAS enzyme activities that might have crucial effects on the outcome of RAS targeted therapies in individual patients. RAS-Fingerprinting in healthy volunteers treated with an Angiotensin-Receptor-Blockers, ACE-Inhibitor or Renin-Inhibitor revealed that the human RAS reacts to different drugs in a very dynamic and specific way. Therefore, RAS-Fingerprinting could contribute to the development of innovative therapeutic approaches affecting the RAS. The implementation of RAS-Fingerprinting into clinical studies would substantially enhance our understanding of the human RAS and could lead to the development of personalized treatment schemes in the management of RAS-associated diseases in the near future.
Chemically Programmed Supramolecular Assembly of Hemoprotein and Streptavidin with Alternating Alignment (2012)

Abwechselnd: Eine Cofaktor-Dyade aus einer Hämgruppe (rot im Bild) und einer Bis(biotin)-Einheit (blau) wurde synthetisiert. Sie bindet spezifisch an Apomyoglobin und Streptavidin. Die 1:1-Assoziation eines disulfidverbrückten Myoglobindimers (grün) mit Streptavidin (grau) in Gegenwart der Dyade führt zu submikrometergroßen Fasern des alternierenden Copolymers.
Abstract 14080: A Phase II Randomized, Double-blind, Controlled Trial of Combined Mesenchymal Stromal Cells and C-kit+ Cardiac Progenitor Cells in Ischemic Heart Failure: The CCTRN CONCERT-HF Trial (2020)

Introduction: Although preclinical studies of cell delivery in models of ischemic heart failure (HF) suggest a beneficial interaction between mesenchymal stromal cells (MSCs) and c-kit+ cardiac progenitor cells (CPCs) resulting in additive therapeutic effects, no clinical trial has examined a combination of different cell types in ischemic HF. Furthermore, comparative studies of different cell products in humans are rare. CONCERT-HF (NCT02501811) is an NHLBI-sponsored, randomized, double-blind, placebo-controlled, Phase II trial of the Cardiovascular Cell Therapy Research Network (CCTRN) investigating feasibility, safety, and efficacy of MSCs and CPCs, alone and in combination, in patients with chronic ischemic HF. Objectives: To address the following questions: Is combined treatment with MSCs and CPCs feasible and safe in patients with ischemic HF? Do MSCs and CPCs, given alone or in combination, alleviate LV dysfunction, reduce scar size, improve quality of life, and/or augment functional capacity? Is either cell type more effective than the other? Is the combination of MSCs and CPCs more efficacious than MSCs alone or CPCs alone? Methods: Patients were randomized (1:1:1:1) to receive i) the combination of autologous bone marrow-derived MSCs and autologous CPCs, ii) MSCs alone, iii) CPCs alone, or iv) placebo. Target doses were 150 x 10 6 MSCs and 5 x 10 6 CPCs. All patients underwent bone marrow aspiration and right heart catheterization. Endomyocardial biopsy was performed only in the MSC + CPC and CPC alone groups; a “sham biopsy” was performed in the MSC alone and placebo groups. All patients underwent study product injection using the NOGA ® XP Mapping System and were followed for 12 months. Results: A total of 125 patients (116 M, 9 F), 62.5 ± 8.9 years old, were enrolled at 7 CCTRN centers between Nov 2016 and Oct 2018. Baseline LVEF (cardiac MRI) was 28.6 ± 6.1% with a mean scar size of 31.8 ± 10.9 g and NYHA class II (80%) or class III (15.2%). Conclusions: CONCERT-HF is the first cell therapy trial to assess a combination of different cell types and to directly compare two different cell products in patients with HF. All patients will complete follow-up by the end of June and final primary (12-month) safety and outcomes data will be available in August 2020.
Design of Power-Optimized Thermal Cantilevers for Scanning Probe Topography Sensing (2009)

This paper reports on design optimization of cantilever-based thermal topography sensors using finite-element simulations, their fabrication and characterization. Measurements demonstrate vertical distance sensitivities DeltaR/R of 2times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , yielding sub-angstrom resolution at bandwidths of several tens of kHz and at powers on the order of 1 mW.
Suppl. Figure S5 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S5: Elevated cytoplasmic ROS induces apoptosis after the treatment with neocuproine&lt;/p&gt;
Figure S3 from Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis (2023)

&lt;p&gt;Molecular heterogeneity in cervical carcinomas (TCGA).&lt;/p&gt;
Think-Aloud Computing: Supporting Rich and Low-Effort Knowledge Capture (2021)

When users complete tasks on the computer, the knowledge they leverage and their intent is often lost because it is tedious or challenging to capture. This makes it harder to understand why a colleague designed a component a certain way or to remember requirements for software you wrote a year ago. We introduce think-aloud computing, a novel application of the think-aloud protocol where computer users are encouraged to speak while working to capture rich knowledge with relatively low effort. Through a formative study we find people shared information about design intent, work processes, problems encountered, to-do items, and other useful information. We developed a prototype that supports think-aloud computing by prompting users to speak and contextualizing speech with labels and application context. Our evaluation shows more subtle design decisions and process explanations were captured in think-aloud than via traditional documentation. Participants reported that think-aloud required similar effort as traditional documentation.
Quantum emitters in hexagonal boron nitride and plasmonic enhancement (2022)

Two-dimensional hexagonal boron nitride (hBN) has emerged as a promising platform for quantum applications as a host of a plethora of quantum emitters (QEs), including optically active spin defects. It is critical to achieve position-controlled generation of these QEs and their integration with photonic/plasmonic structures. In this work, we demonstrate a novel method to deterministically create single QEs in hBN by nanoindentation with atomic force microscopy, with a yield of >30% for various indent sizes. Furthermore, we also demonstrate a route to enhance the brightness of spin defects in hBN up to 120 times by coupling them with nano-patch antennas.