gebhart/patrepeval huggingface dataset:
Bias stress stability of zinc-tin-oxide thin-film transistors with Al2O3 gate dielectrics (2010)

The bias stability of zinc-tin-oxide (ZTO) thin-film transistors (TFTs) with either Al2O3 gate dielectrics deposited via atomic layer deposition (ALD) or SiO2 gate dielectrics deposited via plasma-enhanced chemical vapor deposition (PECVD) was compared. Both device types showed incremental mobility ≥11 cm2/V s, subthreshold slopes &amp;lt;0.4 V/dec, and ION/IOFF ratios of ∼107. During repeated ID-VGS sweeping, both device types showed positive parallel shift of the turn-on voltage (VON) without significant degradation of subthreshold slope or mobility, consistent with electron trapping without creation of new traps. A smaller VON shift was observed in the SiO2/ZTO devices. In an effort to improve the bias stress stability of the Al2O3/ZTO devices, the impact of ALD temperature, plasma exposure of the Al2O3, and the addition of an interfacial PECVD SiO2 capping layer were investigated. The positive bias stress stability of the Al2O3/ZTO TFTs was found to be relatively unaffected by the Al2O3 ALD temperature, degraded with plasma exposure, and improved by the addition of a thin (∼3 nm) PECVD SiO2 interfacial layer between the Al2O3 dielectric and the ZTO channel. These results point to the vicinity of the Al2O3/ZTO interface as the dominant source of charge trapping.
Syndioselective ring-opening polymerization and copolymerization of trans-1,4-cyclohexadiene carbonate mediated by achiral metal- and organo-catalysts (2015)

A zinc or guanidine catalyst allows highly syndioselective ROP of<italic>rac</italic>-CHDC, and its simultaneous or sequential copolymerization with<italic>rac</italic>-CHC and<sc>l</sc>-LA.
IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice (1998)

Abstract IL-12-induced IFN-γ production is essential for clearance of Yersinia enterocolitica infection. Similar to IL-12, the recently described cytokine IL-18 (IFN-γ-inducing factor) is produced by macrophages and induces IFN-γ production in spleen cells. Therefore, we have investigated the role of IL-18 in Yersinia infection of mice. Heat-killed yersinia-triggered IL-18-promoted IFN-γ production of splenocytes was predominantly dependent on endogenous IL-12 production, whereas IL-12-promoted IFN-γ production was not IL-18 dependent. IL-18-induced IFN-γ production was to a higher degree dependent on IFN-γR-mediated mechanisms and in synergism with IL-2 resulted in at least fivefold higher IFN-γ levels as compared with the combination of IL-12 plus IL-2. Analysis of the effect of IL-18 on IL-12 production of LPS-stimulated peritoneal macrophages revealed that IL-18 decreased LPS-induced IL-12 production, indicating that IL-18 might be involved in negative regulation of IL-12 production. In vivo studies revealed that Yersinia-resistant C57BL/6 mice expressed fourfold higher IL-18 mRNA levels than did susceptible BALB/c mice. Administration of anti-IL-18 Abs caused a 100- to 1000-fold increase in bacterial counts in the spleen of infected mice but did not change IFN-γ production levels. Taken together, our data demonstrate that IL-18 is involved in regulation of cytokine production during the early phase of bacterial infections as well as in clearance of Yersinia infection.
Determination of Kinetic Parameters of Fischer–Tropsch Synthesis in the Presence of a Granular Cobalt Catalyst (2023)

Some kinetic parameters of Fischer–Tropsch synthesis (FTS) were determined in the presence of a granular cobalt/zeolite catalyst. Usually, kinetic studies of granular catalysts are considered to be complicated by external and internal diffusion. We managed to obtain a catalyst with a special structure of the active surface, where sites active in FTS are isolated from each other due to the environment of inactive spinel CoAl2O4 and inter-site transport is provided by an extensive intragranular graphitic network serving simultaneously as a heat-conductive medium. As a result, FTS proceeded in the kinetic region. It was found that the reaction kinetics obey the Arrhenius law; whereas, the activation energy is different in different temperature ranges, i.e., 118.2 kJ/mol in the range of 180–210 °C, and 173.6 kJ/mol in the range of 232–243 °C. This behavior is determined by the presence of zeolite, which becomes active in the secondary transformations of FTS products at temperatures beyond 210 °C.
Biological function of Dictyocaulus viviparus asparaginyl peptidase legumain-1 and its suitability as a vaccine target (2017)

The present study characterized the biological function of the asparaginyl peptidase legumain-1 (LEG-1) of the bovine lungworm Dictyocaulus viviparus and its suitability as a recombinant vaccine against dictyocaulosis. Quantitative real-time PCR and immunoblot analysis revealed LEG-1 to be almost exclusively transcribed and expressed in parasitic lungworm stages. Immunohistochemistry localized the enzyme in the parasite's gut, which was confirmed by immunoblots detecting LEG-1 in the gut as well as male testes. LEG-1 was recombinantly (rLEG-1) expressed in the yeast Pichia pastoris and subsequently analysed in activity assays for its enzyme functions and substrate specificity. For sufficient functionality, rLEG-1 needed trans-activation through D. viviparus cathepsin L-2, indicating a novel mechanism of legumain activation. After trans-activation, rLEG-1 worked best at pH 5·5 and 35-39 °C and cleaved a legumain-specific artificial substrate as well as the natural substrates bovine collagen types I and II. In a clinical vaccination trial, rLEG-1 did not protect against challenge infection. Results of in vitro characterization, transcription pattern and localization enhance the presumption that LEG-1 participates in digestion processes of D. viviparus. Since rLEG-1 needs trans-activation through a cathepsin, it is probably involved in an enzyme cascade and therefore remains interesting as a candidate in a multi-component vaccine.
Thein vivoanti-plasmodial activity of haliclonacyclamine A, an alkaloid from the marine sponge,Haliclonasp. (2011)

The compound haliclonacyclamine A was isolated from the Haliclona sponge at Solomon Islands. It acts as a powerful in vitro and in vivo anti-plasmodial agent against the chloroquine-resistant Plasmodium falciparum strain FCB1and Plasmodium vinckei petteri-infected mice, respectively.
Joint Pixel and Feature-level Domain Adaptation in the Wild. (2018)

Recent developments in deep domain adaptation have allowed knowledge transfer from a labeled source domain to an unlabeled target domain at the level of intermediate features or input pixels. We propose that advantages may be derived by combining them, in the form of different insights that lead to a novel design and complementary properties that result in better performance. At the feature level, inspired by insights from semi-supervised learning in a domain adversarial neural network, we propose a novel regularization in the form of domain adversarial entropy minimization. Next, we posit that insights from computer vision are more amenable to injection at the pixel level and specifically address the key challenge of adaptation across different semantic levels. In particular, we use 3D geometry and image synthesization based on a generalized appearance flow to preserve identity across higher-level pose transformations, while using an attribute-conditioned CycleGAN to translate a single source into multiple target images that differ in lower-level properties such as lighting. We validate on a novel problem of car recognition in unlabeled surveillance images using labeled images from the web, handling explicitly specified, nameable factors of variation through pixel-level and implicit, unspecified factors through feature-level adaptation. Extensive experiments achieve state-of-the-art results, demonstrating the effectiveness of complementing feature and pixel-level information via our proposed domain adaptation method.
An Energy-Efficient High CSNR XNOR and Accumulation Scheme for BNN (2022)

In this brief, we present an energy-efficient and high compute signal-to-noise ratio (CSNR) XNOR and accumulation (XAC) scheme for binary neural networks (BNNs). Transmission gates achieve a large compute signal margin (CSM) and high CSNR for accurate XAC operation. The 10T1C XNOR SRAM bit-cell performs the in-memory XAC operation without pre-charging the larger bitline capacitances and significantly reducing energy consumption per XAC operation. The validation of the proposed XAC scheme is done through the post-layout simulations in 65nm CMOS technology with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$V_{DD}$ </tex-math></inline-formula> of 1 V. The achieved 1 ns of latency and 2.36 fJ of energy consumption per XAC operation are ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$7.2\times $ </tex-math></inline-formula> , <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$7.2\times $ </tex-math></inline-formula> ) and ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$2\times $ </tex-math></inline-formula> , <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.31\times $ </tex-math></inline-formula> ) lower than state-of-the-art digital and analog compute in-memory (CIM) XAC schemes respectively. The proposed XAC design achieves <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$8.6\times $ </tex-math></inline-formula> improvement in figure-of-merit (FoM), over prior state-of-the-art. Moreover, ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sigma /\mu $ </tex-math></inline-formula> ) average of 0.2% from Monte Carlo simulations show that proposed XAC scheme is robust against systematic mismatch and process variations.
Data from Diphenyl Difluoroketone: A Curcumin Derivative with Potent <i>In vivo</i> Anticancer Activity (2023)

&lt;div&gt;Abstract&lt;p&gt;Diphenyl difluoroketone (EF24), a molecule having structural similarity to curcumin, was reported to inhibit proliferation of a variety of cancer cells &lt;i&gt;in vitro&lt;/i&gt;. However, the efficacy and &lt;i&gt;in vivo&lt;/i&gt; mechanism of action of EF24 in gastrointestinal cancer cells have not been investigated. Here, we assessed the &lt;i&gt;in vivo&lt;/i&gt; therapeutic effects of EF24 on colon cancer cells. Using hexosaminidase assay, we determined that EF24 inhibits proliferation of HCT-116 and HT-29 colon and AGS gastric adenocarcinoma cells but not of mouse embryo fibroblasts. Furthermore, the cancer cells showed increased levels of activated caspase-3 and increased Bax to Bcl-2 and Bax to Bcl-xL ratios, suggesting that the cells were undergoing apoptosis. At the same time, cell cycle analysis showed that there was an increased number of cells in the G&lt;sub&gt;2&lt;/sub&gt;-M phase. To determine the effects of EF24 &lt;i&gt;in vivo&lt;/i&gt;, HCT-116 colon cancer xenografts were established in nude mice and EF24 was given i.p. EF24 significantly suppressed the growth of colon cancer tumor xenografts. Immunostaining for CD31 showed that there was a lower number of microvessels in the EF24-treated animals coupled with decreased cyclooxygenase-2, interleukin-8, and vascular endothelial growth factor mRNA and protein expression. Western blot analyses also showed decreased AKT and extracellular signal-regulated kinase activation in the tumors. Taken together, these data suggest that the novel curcumin-related compound EF24 is a potent antitumor agent that induces caspase-mediated apoptosis during mitosis and has significant therapeutic potential for gastrointestinal cancers. [Cancer Res 2008;68(6):1962–9]&lt;/p&gt;&lt;/div&gt;
Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism (2014)

Our results suggest that ZNF804A could be a potential candidate gene mediating the intermediate phenotypes associated with verbal traits in individuals with autism.
Partial Purification, Characterization, and Assay of a Slightly Acidic Insulin-Like Peptide (ILAs) from Human Plasma* (1978)

An insulin radioreceptor assay (RRA) using human placental microsomal membranes was used to measure insulin-like activity (ILA) extracted from human plasma concentrates (Cohn fraction IV-4) by acid ethanol. The soluble activity (ILAs), chromatographed on Sephadex G-75 in 1 M acetic acid, migrated as a small molecule (fractional elution volume, 0.56) ahead of insulin (fractional elution volume, 0.70), whereas at neutral pH, ILAs migrated as a large molecular weight species. The ILAs peak from acid gel filtration on Sephadex was further purified by chromatography on carboxymethyl cellulose (CMC). The ILAs peak from both Sephadex and CMC diluted parallel to the porcine insulin standard in the insulin RRA and was totally unreactive in an insulin RIA. The CMC-purified material was iodinated and purified by binding to and elution from human placental membranes. The binding of [125I]ILAs to human placental membranes was inhibited only minimally by insulin and proinsulin and not at all by epidermal growth factor, nerve growth factor, glucagon, or lactogenic hormones, including human growth hormone. Multiplication-stimulating activity (MSA) inhibited in a manner parallel to ILAs. A Scatchard plot of the binding data was nonlinear. Sephadex ILAs was subjected to isoelectric focusing. The fractions assayed in both insulin and ILAs RRAs yielded comparable results. Peaks of ILA were observed at pHs 5.3, 6.6, and 8.4. When CMC-ILA was subjected to isoelectric focusing in polyacrylamide, a single peak of activity migrating between pH 6.2-6.8 was seen. [125I]ILAs focused at exactly the same pH. Electrophoresis of CMC-ILAs in acid-urea revealed a sharp peak of activity migrating with one of the five protein bands seen after staining. Again, [125I]ILAs comigrated with unlabeled ILAs. The molecular weight of ILAs, as determined on a calibrated Sephadex G-150 column at neutral pH, was 9,000-10,000 daltons. CMC-ILAs stimulated [14C]glucose incorporation into triglycerides of rat adipose tissue and augmented [3H]thymidine incorporation into human fibroblasts, chicken embryo fibroblasts, and BALB 3T3 cells as well as [35S]sulfate incorporation into macromolecules of rabbit chondrocyte culture medium. In summary, ILAs isolated on the basis of a RRA for insulin is a slightly acidic peptide with some of the biological activities expected of a somatomedin.
Multitarget Stool DNA Testing for Colorectal-Cancer Screening (2021)

BACKGROUND An accurate, noninvasive test could improve the effectiveness of colorectal-cancer screening. METHODS We compared a noninvasive, multitarget stool DNA test with a fecal immunochemical test (FIT) in persons at average risk for colorectal cancer. The DNA test includes quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation, and β-actin, plus a hemoglobin immunoassay. Results were generated with the use of a logistic-regression algorithm, with values of 183 or more considered to be positive. FIT values of more than 100 ng of hemoglobin per milliliter of buffer were considered to be positive. Tests were processed independently of colonoscopic findings. RESULTS Of the 9989 participants who could be evaluated, 65 (0.7%) had colorectal cancer and 757 (7.6%) had advanced precancerous lesions (advanced adenomas or sessile serrated polyps measuring ≥1 cm in the greatest dimension) on colonoscopy. The sensitivity for detecting colorectal cancer was 92.3% with DNA testing and 73.8% with FIT (P=0.002). The sensitivity for detecting advanced precancerous lesions was 42.4% with DNA testing and 23.8% with FIT (P<0.001). The rate of detection of polyps with high-grade dysplasia was 69.2% with DNA testing and 46.2% with FIT (P=0.004); the rates of detection of serrated sessile polyps measuring 1 cm or more were 42.4% and 5.1%, respectively (P<0.001). Specificities with DNA testing and FIT were 86.6% and 94.9%, respectively, among participants with nonadvanced or negative findings (P<0.001) and 89.8% and 96.4%, respectively, among those with negative results on colonoscopy (P<0.001). The numbers of persons who would need to be screened to detect one cancer were 154 with colonoscopy, 166 with DNA testing, and 208 with FIT. CONCLUSIONS In asymptomatic persons at average risk for colorectal cancer, multitarget stool DNA testing detected significantly more cancers than did FIT but had more false positive results.
Scaling Analytical Models for Soft Error Rate Estimation Under a Multiple-Fault Environment (2007)

With continuing increase in soft error rates, its foreseeable that multiple faults will eventually need to be considered when modeling circuit sensitivity and evaluating fault- tolerance techniques. Previous work that considers multiple faults assumes the faults are permanent. These assumptions aren't directly valid for soft errors. In this work, we evaluate two currently available models for analyzing circuit sensitivities but subject them to multiple transient fault environments. The first model targets the application of triple modular redundancy (TMR) to a non-branching (no fan-out) circuit with permanent faults. We demonstrate this model's inability to adequately predict sensitivity when circuits with branching are considered and subjected to transient faults. We motivate the need for a model that captures logical masking. This is provided by modifying a soft error rate (SER) estimation algorithm to handle multiple faults and gate input interdependence. We conclude that the simple non-branching model can predict a trade-off threshold for when TMR can benefit a circuit. However accurately predicting the magnitude of reliability changes requires the inclusion of more complicated branching effects and logical masking.
Analysis of Prototype Foamy Virus particle-host cell interaction with autofluorescent retroviral particles (2010)

We have established functional, autofluorescent foamy viral particles as a valuable new tool to study FV--host cell interactions using modern fluorescent imaging techniques. Furthermore, we succeeded for the first time in identifying two cell lines resistant to Prototype Foamy Virus Env-mediated gene transfer. Interestingly, both cell lines still displayed FV Env-dependent attachment of fluorescent retroviral particles, implying a post-binding block potentially due to lack of putative FV entry cofactors. These cell lines might ultimately lead to the identification of the currently unknown ubiquitous cellular entry receptor(s) of FVs.
Shape based 3D model retrieval without query (2007)

We describe our shape based 3D model retrieval method that is based on a browsing technique. With this method, users can retrieve the desired 3D model efficiently without a query model. In previous retrieval systems, users should provide a 3D model as a query to the system. Then, the system retrieves similar 3D models and returns them to the user. However, the problem of how to obtain the query model remains. With our method, users can retrieve the desired 3D model by walking through a virtual 3D space without the query model. At first, 3D shape features are extracted from all the 3D models, and 3D models are arranged and classified in the virtual 3D space so that similar 3D models are placed near each other. This allows the user to easily grasp where the 3D models similar to the desired one are located. After approaching the 3D model that is similar to the desired one, users can focus on all the nearby models, which are usually similar to the desired one. So users can find the desired one efficiently. We also developed two functions to make our method more efficient. Firstly, our method needs to render a large number of 3D models at one time quickly, so we developed a high-speed rendering method. Secondly, to make it easier for the user to choose the desired one from many 3D models, we developed a method to make 3D models face the direction from which users can recognize the shape of the 3D models easily. In addition, we present the results of experiments to evaluate the retrieval efficiency, which shows that our method is four times as fast as a retrieval method using a query model.
Procédé d'obtention d'un matériau composite férroélectrique (2005)

L'invention concerne le domaine des matériaux diélectriques entrant notamment dans la constitution de composants microélectroniques haute fréquence, tels que condensateurs, résonateurs, filtres accordables, lignes de propagation, déphaseurs, etc. ainsi que dans les antennes radar.
Polyisobutylene-toughened poly(methyl methacrylate). 1. Synthesis, characterization, and tensile properties of PMMA-l-PIB networks (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyisobutylene-toughened poly(methyl methacrylate). 1. Synthesis, characterization, and tensile properties of PMMA-l-PIB networksJoseph P. Kennedy and G. Caywood RichardCite this: Macromolecules 1993, 26, 4, 567–571Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ma00056a002https://doi.org/10.1021/ma00056a002research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measuring and modeling electrostatic adhesion in micromachines (2002)

We measure deformations of electrostatically actuated cantilever beams adhered to a substrate and compare results to numerical simulations. Beams are peroxide treated and either supercritically dried or coated with octadecyltrichlorosilane (ODTS). In air with relative humidity (RH) of about 50%, measured deformations are consistent with numerical results when an effective insulator thickness of 14 nm is assumed. This value is a measure of the roughness of the substrate. Deformations are generally reversible for voltages up to 2 V. With RH of 75%, deformations of supercritically dried beams are dominated by capillary rather than electrostatic forces. The ODTS-coated beams exhibit less effect from the capillary forces, as expected for a hydrophobic coating.