gebhart/patrepeval huggingface dataset:
Sensors: Preconcentration of Nitroalkanes with Archetype Metal–Organic Frameworks (MOFs) as Concept for a Sensitive Sensing of Explosives in the Gas Phase (Adv. Funct. Mater. 2/2018) (2018)

Archetype metal-organic frameworks (MOFs) can detect molecules from homemade explosives by a preconcentrator concept, as demonstrated by Klaus Müller-Buschbaum and co-workers in article number 1704250. The MOF enriches trace amounts of the analyte molecules, rendering their detection accessible. This is highly beneficial for places such as airports and their security, with MOFs showing 100-times higher enrichment factors than the state-of-the-art material Tenax TA.
Characterization of a Server Thermal Mass Using Experimental Measurements (2011)

The inevitable increase in the heat dissipation of data center facilities is requiring more efficient approaches in the operation of a data center. Dynamic cooling has been proposed as the approach for enhancing the energy efficiency. Dynamic cooling involves close monitoring of the data center environment with time, using sensors, and taking real time decisions on allocating the cooling resources based on the location of hotspots and concentration of workloads. In order to address this approach, knowing the time it takes for a facility to reach steady state after any variation is crucial for ensuring safe operation of the electronic equipment at all times, and it is a function of thermal mass. The thermal mass of an object is the amount of mass capable of withholding heat, and the time it takes to dissipate that heat into the environment is a function of the material properties. In this study, we use a typical 2U server and explain a procedure in obtaining its thermal mass. The server is operated at different controlled power levels while measurements of fans speed, component temperatures, and inlet and outlet temperatures are taken with time. For the first set of experiments, the server is kept inside a chamber and for the second set it is kept in open space. Ultimately the experimental measurements obtained will be used to obtain a compact model to approximate thermal mass of different servers.
Moderate-degree acidosis is an independent determinant of postoperative bleeding in cardiac surgery. (2015)

Even a moderate degree of postoperative acidosis is associated with a greater postoperative bleeding and surgical revision rate in cardiac surgery patients. Correction of acidosis with bicarbonate does not lead to an improvement of the postoperative bleeding asset.
Information Prediction using Knowledge Graphs for Contextual Malware Threat Intelligence (2021)

Security analysts prepare threat analysis upon investigating an attack, an emerging cyber threat, or a recently discovered vulnerability. Threat intelligence on malware attacks and campaigns is shared on blog posts, reports, analyses, and tweets with varying technical details. Other security analysts use this intelligence to inform them of emerging threats, indicators of compromise, attack methods, and preventative measures. Collectively known as threat intelligence, it is typically in an unstructured format and, therefore, challenging to integrate seamlessly into existing IDPS systems. In this paper, we propose a framework that aggregates and combines CTI - the openly available cyber threat intelligence information. The information is extracted and stored in a structured format using knowledge graphs such that the semantics of the threat intelligence can be preserved and shared at scale with other security analysts. We propose the first semi-supervised open-source knowledge graph (KG) framework, TINKER, to capture cyber threat information and its context. Following TINKER, we generate a Cyberthreat Intelligence Knowledge Graph (CTI-KG). We demonstrate the efficacy of CTI-KG using different use cases and its application for security analysts.
Supplementary Fig. from Epigenetic reversal of acquired resistance to 5-fluorouracil treatment (2023)

Supplementary Fig. from Epigenetic reversal of acquired resistance to 5-fluorouracil treatment
New Role of Pd Hydride as a Sensor of Surface Pd Distributions in Pd−Au Catalysts (2019)

Abstract Isolated or contiguous, the surface distributions of Pd atoms in the Pd−Au bimetallic nanoparticle (NP) catalysts often influence activity and selectivity towards specific reactions. In this study, we used a concomitant Pd hydride formation upon H 2 exposure as a probe of presence of contiguous Pd regions in bimetallic NPs. For demonstrating this method, we prepared silica supported monometallic Pd and bimetallic Pd−Au NPs with a Pd/Au ratio of 25/75 (Pd 25 Au 75 ) and used X‐ray absorption spectroscopy, scanning transmission electron microscopy and infrared spectroscopy to detect and quantitatively analyze the Pd hydride regions. This work provides a new approach to characterizing intra‐particle heterogeneities within the bimetallic NPs at ambient temperature and pressure.
Digital Watermarking of Compressed 3D Meshes (2008)

Abstract — This paper presents a robust watermarking algorithm applied to 3D compressed polygonal meshes. Copyright protection of 3D models becomes very important for many applications using public networks. As some recent compression techniques allow very high compression rates, it is of interest to verify that watermarking techniques support this kind of attack. In this paper we present the complete scheme developed: the compression algorithm, the watermarking algorithm and the mark extraction process. I.
Synthesis and Epoxidation of Methyl trans-5,6-Diacetoxy-1,3-cyclohexadiene-1-carboxylate (1988)

Abstract The (±)-methyl 1,3-cyclohexadiene-1-carboxylate, a useful intermediate for synthesis of derivatives of shikimic acid, was prepared by bromination of (±)-methyl (1,3/2)-2,3-diacetoxy-4-cyclohexene-1-carboxylate, followed by debromination of the major dibromide obtained with zinc dust. Epoxidation of the diene with peracid gave selectively two 3,4-monoepoxides.
Corneal Resistance to Keratolysis After Collagen Crosslinking With Rose Bengal and Green Light (2016)

Crosslinking with RGX increased corneal resistance to digestion by collagenase comparable to that produced by riboflavin and UVA treatment.
Scalability Upper Limit Estimation of Silicon Microring Based Configurable Optical Switches (2019)

Scalability of a Silicon Micro-Ring switch in a Benes architecture is investigated, modelling waveguide non linearity using experimental data and intra/inter-channel crosstalk. The benefits of double ring configuration is demonstrated both regarding stability and scalability.
Determining Adenosine Deaminase 1 (ADA-1) Impact on Immune Memory and Durability as a Molecular Adjuvant in a SARS-CoV-2 DNA Vaccine Formulation (2021)

Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease of 2019 (COVID-19), has infected millions of people causing a global pandemic. SARS-CoV-2 vaccines candidates have demonstrated acute immunogenicity and protection however, it has yet to be demonstrated whether natural or vaccine induced immunity against SARS-CoV-2 induces long term, protective immunity. In this study we sought to understand if adenosine deaminase (ADA), as a molecular adjuvant, can enhance immune memory and durability in the context of a SARS-CoV-2 DNA vaccine. Mice were immunized with a plasmid encoding for SARS-CoV-2 spike alone or in combination with plasmid encoded ADA. Subsequent B and T cell responses were measured until d60pi. In mice co-immunized with ADA, there were increased concentrations of spike receptor binding domain (RBD)-specific IgG in the sera which were found to bind RBD at an increased affinity as well as exhibit increased neutralization capability against SARS-CoV-2 pseudotyped viruses. Additionally, ADA co-immunized mice exhibited increased frequency of RBD specific memory B cells. In regard to T cell responses, mice co-immunized with ADA exhibited increased spike-specific IFN-γ, TNF-a and IL-2 as measured by flow cytometry and ELISpot. The ADA-enhanced anti-spike antibody durability over time was associated with increased frequencies of T follicular helper cells (TFH). Preliminary analysis supports that co-immunization with pADA impacts viral load in a SARS-CoV-2 infection model. These data suggest that ADA enhances immune memory and durability and supports further study with translational focus for enhancement of vaccines.
Structure elucidation of nigricanoside A through enantioselective total synthesis (2015)

Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.
Scaling up electronic structure calculations on quantum computers: The frozen natural orbital based method of increments (2021)

The method of increments and frozen natural orbital (MI-FNO) framework is introduced to help expedite the application of noisy, intermediate-scale quantum (NISQ) devices for quantum chemistry simulations. The MI-FNO framework provides a systematic reduction of the occupied and virtual orbital spaces for quantum chemistry simulations. The correlation energies of the resulting increments from the MI-FNO reduction can then be solved by various algorithms, including quantum algorithms such as the phase estimation algorithm and the variational quantum eigensolver (VQE). The unitary coupled-cluster singles and doubles VQE framework is used to obtain correlation energies for the case of small molecules (i.e., BeH<sub>2</sub>, CH<sub>4</sub>, NH<sub>3</sub>, H<sub>2</sub>O, and HF) using the cc-pVDZ basis set. The quantum resource requirements are estimated for a constrained geometry complex catalyst that is utilized in industrial settings for the polymerization of α-olefins. We show that the MI-FNO approach provides a significant reduction in the quantum bit (qubit) requirements relative to the full system simulations. We propose that the MI-FNO framework can create scalable examples of quantum chemistry problems that are appropriate for assessing the progress of NISQ devices.
Design and Synthesis of Non-Peptide Ras CAAX Mimetics as Potent Farnesyltransferase Inhibitors (1996)

Cysteine farnesylation of the ras oncogene product Ras is required for its transforming activity and is catalyzed by farnesyltransferase (FTase). The Ras carboxyl terminal tetrapeptide CAAX (C is cysteine, A is any aliphatic amino acid, X is methionine or serine) is the minimum sequence for FTase recognition. We report here the design, synthesis, and biological characterization of Ras CAAX non-peptide mimetics in which the cysteine is linked through a reduced pseudopeptide bond to 4-amino-3'-carboxybiphenyl. These non-peptide mimetics are potent inhibitors of FTase (IC50 = 40 nM for the most potent inhibitor) and are highly selective for FTase over GGTase I (geranylgeranyltransferase I). They are not substrates for farnesylation, do not have peptidic features, and have no hydrolyzable bonds. Structure-activity studies reveal the importance of the position of the carboxylic acid on the aryl ring as well as the reduction of the cysteine amide bond. Substitution at the 2-position of 4-amino-3'-carboxybiphenyl increases inhibitory potency, while the removal of the carboxylic acid results in a 10-fold loss of inhibitory activity.
Faculty Opinions recommendation of Direct RNA sequencing. (2010)

Our understanding of human biology and disease is ultimately dependent on a complete understanding of the genome and its functions. The recent application of microarray and sequencing technologies to transcriptomics has changed the simplistic view of transcriptomes to a more complicated view of genome-wide transcription where a large fraction of transcripts emanates from unannotated parts of genomes, and underlined our limited knowledge of the dynamic state of transcription. Most of this broad body of knowledge was obtained indirectly because current transcriptome analysis methods typically require RNA to be converted to complementary DNA (cDNA) before measurements, even though the cDNA synthesis step introduces multiple biases and artefacts that interfere with both the proper characterization and quantification of transcripts. Furthermore, cDNA synthesis is not particularly suitable for the analysis of short, degraded and/or small quantity RNA samples. Here we report direct single molecule RNA sequencing without prior conversion of RNA to cDNA. We applied this technology to sequence femtomole quantities of poly(A)(+) Saccharomyces cerevisiae RNA using a surface coated with poly(dT) oligonucleotides to capture the RNAs at their natural poly(A) tails and initiate sequencing by synthesis. We observed transcript 3' end heterogeneity and polyadenylated small nucleolar RNAs. This study provides a path to high-throughput and low-cost direct RNA sequencing and achieving the ultimate goal of a comprehensive and bias-free understanding of transcriptomes. PMID: 19776739 Funding information This work was supported by: NHGRI NIH HHS, United States Grant ID: R01 HG005230
The tubulin repertoire of Caenorhabditis elegans sensory neurons and its context‑dependent role in process outgrowth (2016)

Microtubules contribute to many cellular processes, including transport, signaling, and chromosome separation during cell division (Kapitein and Hoogenraad, 2015). They are comprised of αβ-tubulin heterodimers arranged into linear protofilaments and assembled into tubes. Eukaryotes express multiple tubulin isoforms (Gogonea et al., 1999), and there has been a longstanding debate as to whether the isoforms are redundant or perform specialized roles as part of a tubulin code (Fulton and Simpson, 1976). Here, we use the well-characterized touch receptor neurons (TRNs) of Caenorhabditis elegans to investigate this question, through genetic dissection of process outgrowth both in vivo and in vitro With single-cell RNA-seq, we compare transcription profiles for TRNs with those of two other sensory neurons, and present evidence that each sensory neuron expresses a distinct palette of tubulin genes. In the TRNs, we analyze process outgrowth and show that four tubulins (tba-1, tba-2, tbb-1, and tbb-2) function partially or fully redundantly, while two others (mec-7 and mec-12) perform specialized, context-dependent roles. Our findings support a model in which sensory neurons express overlapping subsets of tubulin genes whose functional redundancy varies between cell types and in vivo and in vitro contexts.
Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders (2023)

Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.
<title>Home teleradiology system</title> (1997)

The Home Teleradiology Server system has been developed and installed at the Department of Radiology, Georgetown University Medical Center. The main purpose of the system is to provide a service for on-call physicians to view patients' medical images at home during off-hours. This service will reduce the overhead time required by on-call physicians to travel to the hospital, thereby increasing the efficiency of patient care and improving the total quality of the health care. Typically when a new case is conducted, the medical images generated from CT, US, and/or MRI modalities are transferred to a central server at the hospital via DICOM messages over an existing hospital network. The server has a DICOM network agent that listens to DICOM messages sent by CT, US, and MRI modalities and stores them into separate DICOM files for sending purposes. The server also has a general purpose, flexible scheduling software that can be configured to send image files to specific user(s) at certain times on any day(s) of the week. The server will then distribute the medical images to on- call physicians' homes via a high-speed modem. All file transmissions occur in the background without human interaction after the scheduling software is pre-configured accordingly. At the receiving end, the physicians' computers consist of high-end workstations that have high-speed modems to receive the medical images sent by the central server from the hospital, and DICOM compatible viewer software to view the transmitted medical images in DICOM format. A technician from the hospital, and DICOM compatible viewer software to view the transmitted medical images in DICOM format. A technician from the hospital will notify the physician(s) after all the image files have been completely sent. The physician(s) will then examine the medical images and decide if it is necessary to travel to the hospital for further examination on the patients. Overall, the Home Teleradiology system provides the on-call physicians with a cost-effective and convenient environment for viewing patients' medical images at home.
Supplementary Table 1 from T Cell Receptor Genotyping and <i>HOXA/TLX1</i> Expression Define Three T Lymphoblastic Lymphoma Subsets which Might Affect Clinical Outcome (2023)

Supplementary Table 1 from T Cell Receptor Genotyping and &lt;i&gt;HOXA/TLX1&lt;/i&gt; Expression Define Three T Lymphoblastic Lymphoma Subsets which Might Affect Clinical Outcome
Antibodies, Immunity, and COVID-19 (2020)

Conflict of Interest Disclosures: Dr Spellberg reported personal fees from IQVIA and service on multiple data safety monitoring boards for therapeutics for COVID-19, with no financial interest in the sponsors, products, or outcomes of the trials during the conduct of the study. No other disclosures were reported.
Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma (1984)

Stereoisomeric dichloro [1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-3a, (+/-)-3b, (+)-3c, (-)-3d) and their N,N'-dibutyl derivatives (meso-4a, (+/-)-4b, (+)-4c, (-)-4d) were synthesized and tested on antitumor activity. The most active compound, 3d, shows a modest inhibition of the [3H]estradiol receptor interaction and causes a marked effect on the growth of the hormone-dependent human MCF 7 breast cancer cell line. It is also active on the hormone-independent human MDA-MB 231 breast cancer cell line, on the ADJ/PC6 plasmacytoma of the Balb/C mouse, and on the L 5222 leukemia of the BD IX rat. Apparently the inhibition of the MCF 7 cell line is not mediated by the estrogen receptor system. Histopathological studies on 3d revealed very low toxicity.
Template assembled binding loops as functional mimetics of receptors (1998)

A symposium report on synthetic strategies which provide a synthetic entry to a new generation of template assembled synthetic proteins (TASP). [on SciFinder (R)]
Radiofrequency Ablation of the Nerve to the Corrugator Muscle for Elimination of Glabellar Furrowing (1999)

Glabellar furrows are caused by hyperdynamic activity of the corrugator supercilii muscles. A minimally invasive, percutaneous technique for eliminating glabellar furrows is described. An insulated, bipolar needle is inserted vertically through the eyebrow skin to entrap the corrugator nerve plexus. To confirm proper positioning, a stimulating current is delivered to the needle during observation of corrugator supercilii muscle response. Radiofrequency energy is then delivered to the needle, thereby ablating the intervening nerve tissue. This technique is in the early stage of optimization and is being evaluated in an ongoing Stanford University Human Subjects protocol, Stanford, Calif. The preliminary results are reported herein.
Local Anesthetics Inhibit Uterine Activity in vitro (2003)

Local anesthetics administered in situ consistently inhibit or completely arrest overall myometrial activity. These agents may prove clinically useful in preterm labor management, if administered locally to the myometrium via suitable slow release drug delivery systems, warranting further trials in vivo.
Supplementary Table 1 from Chronic Myelogenous Leukemia– Initiating Cells Require Polycomb Group Protein EZH2 (2023)

&lt;p&gt;List of gene sets.&lt;/p&gt;
Coupling Electrocatalytic CO2 Reduction with Thermocatalysis Enables the Formation of a Lactone Monomer (2021)

Carbonylation reactions that generate high-value chemical feedstocks are integral to the formation of many industrially significant compounds. However, these processes require the use of CO, which is invariably derived from fossil-fuel-reforming reactions. CO may also be generated through the electroreduction of CO<sub>2</sub> , but the coupling of these two processes is yet to be considered. Merging electrocatalytic reduction of CO<sub>2</sub> to CO with thermocatalytic use of CO would expand the range of the chemicals produced from CO<sub>2</sub> . This work describes the development of a system coupling a high-pressure CO<sub>2</sub> electrolytic cell containing a bimetallic ZnAg catalyst at the cathode for production of CO with a reactor with a Faradaic efficiency of >90 % where high pressure CO is used for carbonylating propylene oxide into β-butyrolactone by thermal catalysis, the latter step having a reaction yield above 80 %. Although the production of monomers and polymers from CO<sub>2</sub> is currently limited to organic carbonates, this strategy opens up the access to lactones from CO<sub>2</sub> , for the formation of polyesters.
Poly(ϵ‐caprolactam)–poly(butadiene‐co‐acrylonitrile) block copolymers. I. Synthesis, characterization, mechanical properties, and morphology (1994)

Abstract Poly(ϵ‐caprolactam)–poly(butadiene‐co‐acrylonitrile) block copolymers have been synthesized that were suitable for the pultrusion process. The effects of amine‐terminated butadiene acrylonitrile copolymer (ATBN) content on copolymerization rate, conversion, crystallization behaviors, and mechanical properteis and morphology of NY 6–ATBN copolymers were investigated. The conversion was over 90% and the copolymerization was completed within 3 min (up to 20 wt % ATBN) at 145–165°C. The higher the [MgBr—CPL] (ϵ‐caprolactam magnesium bromide) initiator concentration, the lower the molecular weight [or intrinsic viscosity (IV)] of the copolymers and the less the copolymerization time. Relationships among mechanical properties, morphology, and structure of copolymers have been studied. The notched Izod impact strength of the NY 6–ATBN copolymers (&lt; 10.5 wt % ATBN) increased more than 10‐fold, while the flexural modulus only reduced 10%. Transmission electron micrographs showed that ATBN rubber particle size changed slightly with ATBN content, but interparticle distance ( T ) decreased with increasing ATBN content. As T decreased, the ductility of the copolymers increased. When ATBN content reached 10.5–13 wt % ( T = 0.32–0.45 μm), the copolymers showed a very high ductile behavior. © 1994 John Wiley &amp; Sons, Inc.