gebhart/patrepeval huggingface dataset:
Joining of ceramic tubes using a high-power 83-GHz Millimeter-wave beam (2005)

High purity, high density alumina tubes have been successfully joined using a high-power millimeter-wave beam. This technique exploits the use of the beam-forming capability of an 83-GHz gyrotron-based system allowing the deposition of energy into a narrow region surrounding the joint area with minimal heating (<100/spl deg/C) of the metal fixturing (a modified microlathe). The power deposition and heating was modeled using a closed form analytical approach that has been compared with experimental results. The modeling results indicated areas of improvement that were implemented to make the process more effective. Conjoined tubes resulting from this technology meet the requirements for the dielectric-loaded accelerator (DLA) being developed by the Argonne National Laboratory.
Potential antitumor agents. 16. 4'-(Acridin-9-ylamino)methanesulfonanilides (1975)

The structure-antileukemic activity (L1210) relationships for sulfonanilide ring-substituted variants of 4'-(acridin-9-ylamino)methanesulfonanilides have been investigated. Electron-donor substituents are necessary for antileukemic activity and it is suggested that high electron density at the 6' position is associated with high activity. A 3'-OCH3 function markedly increases (2-8-fold) potency with a variety of acceptable acridine ring substituents. Further variants with hydrophobic acridine 3-substituents have been shown to be more active than expected on the basis of overall molecular hydrophilic-lipophilic balance. There is a size limit to 3-substituents which may acceptably be as large as an iodine atom but should be smaller than an isoporpyl function.
Blind I/Q Imbalance Compensation in OFDM Receivers Based on Adaptive I/Q Signal Decorrelation (2005)

Due to its simple structure and relaxed requirements for radio frequency (RF) filtering, the so called direct-conversion or zero-IF architecture is gaining more and more interest in radio receiver design. One practical problem in the analog I/Q processing section is the amplitude and phase matching of the I and Q signal branches. With reasonable design and implementation costs, amplitude and phase mismatches in the order of 1-5% and 1-5/spl deg/ are feasible. The performance degradation due to these levels of I/Q mismatches is, however, considerable, especially in case of OFDM signals, where the mismatches cause certain type of intercarrier interference (ICI). In this paper, a novel structure for I/Q mismatch compensation is proposed for OFDM systems. The proposed compensator operates in the time domain and is based on adaptive I/Q decorrelation. It has low computational complexity and is basically independent of other receiver and system related nonidealities, especially frequency offsets and multipath propagation. Furthermore, the compensator is blind in the sense that no known training signals are needed. The effectiveness of the proposed structure is illustrated using computer simulations, showing impressive performance in practical signaling environments.
Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells. (1990)

The production and characterization of an antibody to rat liver CTP:phosphocholine cytidylyltransferase is described. This antibody quantitatively precipitated cytidylyltransferase from both rat liver and HeLa cell cytosol. Following affinity purification, the antibody was used to demonstrate, for the first time, the phosphorylation of cytidylyltransferase in vivo. Following the immunoprecipitation of cytidylyltransferase from HeLa cells, acid hydrolysis, and thin layer electrophoresis of the amino acids, only [32P]phosphoserine was detected. The phosphorylation state of cytidylyltransferase in HeLa cells was examined following treatment with phorbol ester for 1 h. In agreement with previous studies, the incorporation of [3H]choline into phosphatidylcholine via the CDP-choline pathway was stimulated 5-fold in cultures of HeLa cells following treatment with phorbol ester for 1 h. However, no appreciable translocation of cytidylyltransferase was detected, despite the utilization of two different methods of cell lysis. Furthermore, the inclusion of phosphatase inhibitors and chelators of divalent cations in the homogenization buffers had no effect on the observed distribution or activity of the enzyme. Immunoprecipitated cytidylyltransferase was phosphorylated to the same extent, and on serine residues only, in both control and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-treated cells. Measurement of the pool sizes of the aqueous intermediates of the CDP-choline pathway, following TPA treatment, revealed a modest decrease in the phosphocholine pool only, consistent with an activation of cytidylyltransferase.
[Luteolytic action of LHRH in women]. (1978)

Several subcutaneous administrations of 250 microgram of LHRH (4 or 5 adminstrations at 4-hourly intervals per day) between the 2nd and 7th day post-ovulation in 4 normal women led to early luteolysis as demonstrated by a fall in serum progesterone concentration and early onset (2 to 3 days earlier) of menstruation.
Generation of shear waves as an effective mechanism of dynamic load of the lithotripter shock wave on the kidney stone (2003)

A number of stone comminution mechanisms have been studied in lithotripsy. Except cavitation erosion, these mechanisms (namely, spallation, dynamic fatigue, shear, and circumferential compression) are associated with stresses generated in the stone by the shock wave. The mechanical load on the stone depends on the waveform and stone structure, size, and shape. We modeled the propagation of lithotripter shock waves through a cylindrical stone with a finite differences simulation based on Lame’s equation. The stone parameters were similar to those of natural kidney stones. A new mechanism of tensile stress generation is predicted that may be 5–10 times more efficient than spalling. Shear elasticity of the stone gave rise to the peak tensile strain in the bulk of the stone; this strain occurs near the stone axis due to coherent arrival of shear waves from the front edges of the stone. The position of the region of maximum strain and direction of corresponding tensile forces is similar to those predicted by the spalling mechanism. The modeling also showed that circumferential compression is not activated by the dynamic load produced by a short shock wave typical for lithotripsy. [Work supported by NIH PO1 DK43881, RO1 DK55674 and FOGARTY, CDRF, ONRIFO, and NSBRI.]
Continuous wave excitation two‐photon fluorescence microscopy exemplified with the 647‐nm ArKr laser line (1998)

We report on efficient two-photon fluorescence imaging in beam scanning microscopy by exciting UV dyes at the 647-nm line of a continuous wave ArKr mixed gas laser. For a numerical aperture of 1.4 (oil), we used an illumination power of up to 210 mW at the sample. High-resolution images were obtained for DAPI-labelled cell nuclei within 4-60 s. Our method is a simple two-photon alternative to UV confocal imaging with the potential of becoming a very useful feature of laser scanning microscopy.
Canal: A Flexible Interconnect Generator for Coarse-Grained Reconfigurable Arrays (2023)

The architecture of a coarse-grained reconfigurable array (CGRA) interconnect has a significant effect on not only the flexibility of the resulting accelerator, but also its power, performance, and area. Design decisions that have complex trade-offs need to be explored to maintain efficiency and performance across a variety of evolving applications. This paper presents Canal, a Python-embedded domain-specific language (eDSL) and compiler for specifying and generating reconfigurable interconnects for CGRAs. Canal uses a graph-based intermediate representation (IR) that allows for easy hardware generation and tight integration with place and route tools. We evaluate Canal by constructing both a fully static interconnect and a hybrid interconnect with ready-valid signaling, and by conducting design space exploration of the interconnect architecture by modifying the switch box topology, the number of routing tracks, and the interconnect tile connections. Through the use of a graph-based IR for CGRA interconnects, the eDSL, and the interconnect generation system, Canal enables fast design space exploration and creation of CGRA interconnects.
Construction of Leakage Current Measuring System to Separate it into Three Frequency Components for Evaluating Surface Degradation of Polymeric Insulating Materials (2002)

We constructed a leakage current measuring system which can separate it into three frequency components in frequency domain, low (0_??_360 Hz), middle (360 Hz_??_5 kHz), and high (10MHz) frequency. The low, middle and high frequency components are intended to correspond to surface leakage current, dry-band arc and corona discharge, respectively. We verified the developed system so as to confirm that the leakage current mainly containing dry-band arc component has frequency spectrums dominating near several kHz. This new separative leakage current measuring system was applied to the salt-fog test using porcelain samples as a reference. Consequently, we found that the proposed separative measurement is effective to discuss quantitatively the degradation properties of polymer materials as well in the accelerated degradation evaluation test.
Identification of New Potent GPR119 Agonists by Combining Virtual Screening and Combinatorial Chemistry (2012)

Virtual screening in a huge collection of virtual combinatorial libraries has led to the identification of two new structural classes of GPR119 agonists with submicromolar in vitro potencies. Herein, we describe the virtual screening process involving feature trees fragment space searches followed by a 3D postprocessing step. The in silico findings were then filtered and prioritized, and finally, combinatorial libraries of target molecules were synthesized. Furthermore the so-called "activity-anchor principle" is introduced as an element to increase the chance to generate true hits. An activity anchor is a structural element expected to provide key contributions to a certain biological activity. Application of this technique has led to the discovery of two new GPR119-agonist hit series, one of which was further optimized to progress as a novel lead class.
ISOLATION AND CHARACTERIZATION OF A NEW ANTIBIOTIC, NEOPLURAMYCIN (1970)

A new crystalline antibiotic named neopluramycin, which inhibits growth of Gram-positive bacteria, leukemia L-1210 in mice and Yoshida rat sarcoma cells in tissue culture, has been isolated from the cultured broth of a strain of Streptomyces pluricolorescens. It was obtained as orange crystals, and analytical data and molecular weight determination are consistent with the empirical formula C40H50N20O10. Neopluramycin resembles pluramycin A, but is differentiated by its antibacterial spectrum, toxicity, thin-layer chromatography, and infrared absorption spectrum.
Caldithrix palaeochoryensis sp. nov., a thermophilic, anaerobic, chemo-organotrophic bacterium from a geothermally heated sediment, and emended description of the genus Caldithrix (2009)

A novel thermophilic, strictly anaerobic, chemo-organotrophic bacterium, designated MC(T), was isolated from a geothermally heated sediment of a marine hydrothermal system at Palaeochory Bay, Milos, Greece. Cells of strain MC(T) were rods of variable length (4-12 mum) and width (0.2-0.3 mum), occurring as single cells or forming large aggregates that were visible as flocs. Strain MC(T) grew optimally at pH 7.0 and 60 degrees C and with 3 % (w/v) NaCl. Strain MC(T) grew chemo-organoheterotrophically and fermented peptides and di- and polysaccharides in the presence of 0.1 g yeast extract l(-1). The DNA G+C content of strain MC(T) was 43.3 mol%. Phylogenetic analysis of the 16S rRNA gene sequence placed strain MC(T) within the genus Caldithrix. However, strain MC(T) possessed certain phenotypic features that differentiated it from the type strain of the only species of the genus Caldithrix described to date. On the basis of phylogenetic and phenotypic characteristics, it is proposed that strain MC(T) represents a novel species, Caldithrix palaeochoryensis sp. nov. The type strain is MC(T) (=DSM 21940(T) =VKM B-2536(T)). In addition, an emended description of the genus Caldithrix is presented.
Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study (2018)

Abnormalities of the retinal microvasculature and cardiac structure are seen in offspring of HDP in midadulthood. These findings may need to be considered in future primary prevention strategies of cardiovascular disease among offspring of HDP.
Connected and autonomous vehicles: What challenges in ergonomics? (2019)

Connected and Autonomous Vehicles (CAVs) hold out the hope of a safer, more fluid and responsible mobile world. Today, some pilots are taking place in different countries. Beyond the technological challenges, it is now necessary to focus on the human dimension of CAVs. What are the acceptance factors for future users? What new modes of human-VAC interaction are to be imagined? What driving training should be developed to prepare drivers of these vehicles without a driver? The purpose of this paper is to list some challenges for ergonomics, in order to feed the debates in which some researchers are already involved.
Adaptive Multi-Resource Allocation for Cloudlet-Based Mobile Cloud Computing System (2015)

Mobile cloud computing utilizing cloudlet is an emerging technology to improve the quality of mobile services. In this paper, to better overcome the main bottlenecks of the computation capability of cloudlet and the wireless bandwidth between mobile devices and cloudlet, we consider the multi-resource allocation problem for the cloudlet environment with resource-intensive and latency-sensitive mobile applications. The proposed multi-resource allocation strategy enhances the quality of mobile cloud service, in terms of the system throughput (the number of admitted mobile applications) and the service latency. We formulate the resource allocation model as a semi-Markov decision process under the average cost criterion, and solve the optimization problem using linear programming technology. Through maximizing the long-term reward while meeting the system requirements of the request blocking probability and service time latency, an optimal resource allocation policy is calculated. From simulation result, it is indicated that the system adaptively adjusts the allocation policy about how much resource to allocate and whether to utilize the distant cloud according to the traffic of mobile service requests and the availability of the resource in the system. Our algorithm outperforms greedy admission control over a broad range of environments.
Final Report: Use of Graphite Foam as a Thermal Performance Enhancement of Heavy Hybrid Propulsion Systems (2011)

Oak Ridge National Laboratory's graphite foam has the potential to be used as a heat exchanger for the Army's Future Combat System Manned Ground Vehicle and thus has the potential to improve its thermal performance. The computational fluid dynamics (CFD) program FLOW3D was used to develop a new CFD model for the graphite foam to be used in the development of a proper heat exchanger. The program was calibrated by first measuring the properties of the solid foams and determining the parameters to be used in the CFD model. Then the model was used to predict within 5% error the performance of finned foam heat sinks. In addition, the f factors and j factors commonly used to predict pressure drop and heat transfer were calculated for both the solid and finned structures. There was some evidence that corrugating the foams would yield higher j/f ratios than state of the art heat exchangers, confirming previously measured data. Because the results show that the CFD model was validated, it is recommended that the funding for Phases 2 through 5 be approved for the design of both the finned heat exchanger using tubes and round fin structures and the solid foam design using corrugated foams. It was found that the new CFD model using FLOW3D can predict both solid foam heat transfer and finned foam heat transfer with the validated model parameters. In addition, it was found that the finned foam structures exhibited j/f ratios that indicate that significant heat transfer is occurring within the fin structures due to aerodynamically induced flow, which is not present in solid aluminum fin structures. It is possible that the foam surfaces can act as turbulators that increase heat transfer without affecting pressure drop, like the vortex generators seen in state of the art heat exchangers. These numbers indicate that the foam can be engineered into an excellent heat exchanger. It was also found that corrugating the solid foams would increase the j/f ratio dramatically, allowing the solid foams to compete directly with standard heat exchangers. Although corrugated L1 foam samples have not been produced (attempts are under way), it is possible that their j/f ratio can be even higher than those of the finned structures.
Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia* (2000)

To investigate the cause and effect relationship between hyperinsulinemia and the increased amounts of farnesylated p21Ras, we performed hyperinsulinemic euglycemic clamps in normal weight volunteers as well as in normal mice and dogs. Insulin infusions significantly raised the amounts of farnesylated p21Ras in the white blood cells of humans, in liver samples of mice and dogs, and in aorta samples of mice. Obese hyperinsulinemic individuals and dogs (made hyperinsulinemic by surgical diversion of the pancreatic outflow from the portal vein into the vena cava) displayed increased amounts of farnesylated p21Ras before the hyperinsulinemic clamps. Infusions of insulin did not alter the already increased levels of farnesylated p21Ras in these experimental models. To further investigate the role of acquired insulin resistance in modulating insulin's effect on p21Ras prenylation, we induced insulin resistance in rats by glucosamine infusion. Insulin-resistant glucosamine-treated animals displayed significantly increased farnesylated p21Ras in response to insulin infusion compared to that in control saline-treated animals. Transgenic models of insulin resistance (heterozygous insulin receptor substrate-1 knockout mice, A-ZIP/F-1 fatless mice, and animals overexpressing glutamine:fructose-6-phosphate amidotransferase) contained increased amounts of farnesylated p21Ras. We conclude that hyperinsulinemia, either endogenous (a prominent feature of insulin resistance) or produced by infusions of insulin, increases the amounts of farnesylated p21Ras in humans, mice, and dogs. This aspect of insulin action may represent one facet of the molecular mechanism of the potentially detrimental influence of hyperinsulinemia.
Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic (2005)

[reaction: see text] A terpyridine scaffold has been designed as an alpha-helix mimetic. A facile synthesis of the ortho-functionalized 2,3'-oligopyridine has been accomplished using sequential Bohlmann-Rahtz heteroannulation reactions.
Response to ‘‘Comment on ‘Aluminum cladding of high T c superconductor by thermocompression bonding’ ’’ [Appl. Phys. Lett. 5 5, 321 (1989)] (1989)

We are not convinced that the objections raised by Harman require basic me tallurgical changes , nor that further development is a waste of time and expen se. It is our belief that these grapes ought first to be tasted before they be declared sour. (AIP)
Heterogeneous integration in silicon photonics through micro-transfer-printing (2019)

Micro-transfer-printing enables the intimate integration of a wide range of opto-electronic micro-components on a silicon photonics platform. This technique allows for wafer-scale integration in a massively parallel manner with high alignment accuracy, high throughput and high yield, therefore leading to a cost reduction of complex photonic integrated circuits.
Infrared spectral studies of metal binding effects on the secondary structure of bean plastocyanin (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared spectral studies of metal binding effects on the secondary structure of bean plastocyaninJeffrey W. Hare, Edward I. Solomon, and Harry B. GrayCite this: J. Am. Chem. Soc. 1976, 98, 11, 3205–3209Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/ja00427a025https://doi.org/10.1021/ja00427a025research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the Place of Text Data in Lifelogs, and Text Analysis via Semantic\n Facets (2016)

Current research in lifelog data has not paid enough attention to analysis of\ncognitive activities in comparison to physical activities. We argue that as we\nlook into the future, wearable devices are going to be cheaper and more\nprevalent and textual data will play a more significant role. Data captured by\nlifelogging devices will increasingly include speech and text, potentially\nuseful in analysis of intellectual activities. Analyzing what a person hears,\nreads, and sees, we should be able to measure the extent of cognitive activity\ndevoted to a certain topic or subject by a learner. Test-based lifelog records\ncan benefit from semantic analysis tools developed for natural language\nprocessing. We show how semantic analysis of such text data can be achieved\nthrough the use of taxonomic subject facets and how these facets might be\nuseful in quantifying cognitive activity devoted to various topics in a\nperson's day. We are currently developing a method to automatically create\ntaxonomic topic vocabularies that can be applied to this detection of\nintellectual activity.\n