gebhart/patrepeval huggingface dataset:
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions (2014)

Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting vessel development, but what regulates this process is largely unknown. Angiopoietin 2 (Ang2) deficiency leads to abnormal lymphatic vessels. Here we found that an ANG2-blocking antibody inhibited embryonic lymphangiogenesis, whereas endothelium-specific ANG2 overexpression induced lymphatic hyperplasia. ANG2 inhibition blocked VE-cadherin phosphorylation at tyrosine residue 685 and the concomitant formation of button-like junctions in initial lymphatics. The defective junctions were associated with impaired lymph uptake. In collecting lymphatics, adherens junctions were disrupted, and the vessels leaked upon ANG2 blockade or gene deletion. ANG2 inhibition also suppressed the onset of lymphatic valve formation and subsequent valve maturation. These data identify ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development.
Ficolin-2 serum levels predict the occurrence of acute coronary syndrome in patients with severe carotid artery stenosis (2021)

ficolins support intraplaque immune cell recruitment and inflammatory processes ultimately leading to plaque vulnerability. Especially for ficolin-2 a strong predictive value toward adverse cardiovascular events was demonstrated. This evidence offers potentially new pharmacological target to dampen the inflammatory mechanisms leading to plaque vulnerability.
Discovery of emerging patterns from nearest neighbors (2003)

In this paper, we propose a scalable classifier that uses jumping emerging patterns (JEPs), which are combinations of values that occur in one class. The original classifier, DeEPs, is an instance-based classifier that operates on all instances in real-time. It discovers maximal patterns that occur throughout the entire database and identifies JEPs by using these patterns. The necessary computational effort, though, is likely to increase when DeEPs is applied to a large database. Our proposed classifier operates on the nearest neighbors of a test instance. This reduction of instances improves scalability as the database volume increases. Moreover, our classifier imposes a restriction regarding JEPs discovery, so that it excludes patterns that cannot be identified as either correct JEPs or JEPs caused by the maximal patterns missing from nearest neighbors. These probably incorrect JEPs are specialized with additional items and participate in class determination. Our classifier perform significantly faster with these two enhancements, while it remains as accurate as the original classifier.
Discriminating brain microbleeds using phase contrast MRI in a multicentre clinical setting (2013)

International audience
Interpolation of a surface from sets of discrete height data of different statistical characteristics (1976)

This paper presents and analyzes a method for the interpolation of a unique surface from two sets of independent digital height data of differing statistical characteristics. This method is based on linear prediction and thus relies on the concepts of auto- and cross-covariance functions. The linear prediction algorithm for two sets of digital height measurements is first derived and then evaluated using the method of moving averages and bilinear interpolation for comparison. It is found that the overall root mean square interpolation errors of linear prediction are similar to those from moving averages and bilinear interpolation. This accuracy performance, together with the well known potential for controlled filtering of measuring errors and good-behavior in areas of poor control, makes linear prediction a versatile and general method for interpolating a unique surface from two sets of digital height data, with applications in photogrammetric mapping, remote sensing, and other fields.
Bending flexibility, kinking, and buckling characterization of ZnO nanorods/nanowires grown on different substrates by high and low temperature methods (2008)

Nanomechanical tests of bending flexibility, kinking, and buckling failure characterization of vertically aligned single crystal ZnO nanorods/nanowires were performed quantitatively by nanoindentation technique. These nanostructures were grown by the vapor liquid solid (VLS) method, a relatively high temperature approach, and the aqueous chemical growth (ACG) method, a relatively low temperature approach on different substrates, including SiC and Si. The first critical load at the inflection point found for the ZnO nanorods/nanowires grown by ACG method was 105 μN on the SiC substrates and 114 μN on the Si substrates. The corresponding buckling energies calculated from the force-displacement curves were 3.15×10−12 and 2.337×10−12 J, respectively. Similarly, for the samples grown by the VLS method, the first critical load at the inflection point and the corresponding buckling energies were calculated from the force-displacement curves as 198 μN and 7.03×10−12 J on the SiC substrates, and 19 μN and 1.805×10−13 J on the Si substrates. Moreover, the critical buckling stress, strain, and strain energy were also calculated for all samples. The strain energy for all samples was much less than the corresponding buckling energy. This shows that our as-grown samples are elastic and flexible. The elasticity measurement was performed for all the samples before reaching the first critical and kinking inflection point, and we subsequently observed the bending flexibility, kinking, and buckling phenomena on the same nanorods/nanowires. We observed that the loading and unloading behaviors during the bending test of the as-grown samples were highly symmetrical, and also that the highest point on the bending curves and the first inflection and critical point were very close. ZnO nanorods/nanowires grown on SiC by the ACG method, and those grown by the VLS method on Si substrates, show a linear relation and high modulus of elasticity for the force and displacement up to the first inflection and critical point. The results also show that the elasticity of the ZnO single crystal is approximately linear up to the first inflection point, is independent of the growth method and is strongly dependent on the verticality on the surface of the substrates. In addition, the results show that after the first buckling point, the nanorods/nanowires have plasticity, and become more flexible to produce multiple kinks.
Complete self-recovery of photoluminescence of photodegraded cesium lead bromide quantum dots (2019)

Self-readsorption of surface ligands completely restores the photoluminescence of CsPbBr<sub>3</sub> quantum dots damaged by excitation light.
Refractive-index profiling of azimuthally asymmetric optical fibers by microinterferometric optical phase tomography (2005)

Accurate nondestructive refractive-index profiling is needed in the modeling, design, and manufacturing of optical fibers and fiber devices. Most profile measurement techniques cannot correctly characterize fibers with small or irregular refractive-index variations over their cross sections. Microinterferometric optical phase tomography (MIOPT) is a technique that allows measurement of fiber refractive-index profiles exhibiting such variations. We present the first demonstration, to our knowledge, of MIOPT. The profile of a polarization-maintaining fiber is measured by MIOPT and shown to be in agreement with (destructive) fiber end-face measurements. MIOPT is also applied to the limiting case of a symmetric single-mode fiber.
Integrative genetic and genomic networks identify microRNA associated with COPD and ILD (2023)

Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are clinically and molecularly heterogeneous diseases. We utilized clustering and integrative network analyses to elucidate roles for microRNAs (miRNAs) and miRNA isoforms (isomiRs) in COPD and ILD pathogenesis. Short RNA sequencing was performed on 351 lung tissue samples of COPD (n = 145), ILD (n = 144) and controls (n = 64). Five distinct subclusters of samples were identified including 1 COPD-predominant cluster and 2 ILD-predominant clusters which associated with different clinical measurements of disease severity. Utilizing 262 samples with gene expression and SNP microarrays, we built disease-specific genetic and expression networks to predict key miRNA regulators of gene expression. Members of miR-449/34 family, known to promote airway differentiation by repressing the Notch pathway, were among the top connected miRNAs in both COPD and ILD networks. Genes associated with miR-449/34 members in the disease networks were enriched among genes that increase in expression with airway differentiation at an air-liquid interface. A highly expressed isomiR containing a novel seed sequence was identified at the miR-34c-5p locus. 47% of the anticorrelated predicted targets for this isomiR were distinct from the canonical seed sequence for miR-34c-5p. Overexpression of the canonical miR-34c-5p and the miR-34c-5p isomiR with an alternative seed sequence down-regulated NOTCH1 and NOTCH4. However, only overexpression of the isomiR down-regulated genes involved in Ras signaling such as CRKL and GRB2. Overall, these findings elucidate molecular heterogeneity inherent across COPD and ILD patients and further suggest roles for miR-34c in regulating disease-associated gene-expression.
Predictive factors for survival in patients with inoperable Klatskin tumors. (2006)

In Klatskin tumors, resolution of jaundice through an optimal stenting results in a better survival rate. Additional independent predictive factors are the absence of a mass-type tumor, liver metastases and post-drainage complications.
Formation Dynamics and Snapshots of Self-injection-locking Dark Solitons (2021)

We propose a model for understanding dark solitons formation dynamics in self-injection-locking laser-resonator systems using dynamical instabilities and domain walls. Snapshots of solitons are captured with dual-comb imaging techniques and validate the model.
Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion (2008)

Lung cancer is characterized by abnormal cell growth and invasion, and the actin cytoskeleton plays a major role in these processes. The focal adhesion protein paxillin is a target of a number of oncogenes involved in key signal transduction and important in cell motility and migration. In lung cancer tissues, we have found that paxillin was highly expressed (compared with normal lung), amplified (12.1%, 8 of 66) and correlated with increased MET and epidermal growth factor receptor (EGFR) gene copy numbers, or mutated (somatic mutation rate of 9.4%, 18 of 191). Paxillin mutations (19 of 21) were clustered between LD motifs 1 and 2 and the LIM domains. The most frequent point mutation (A127T) enhanced lung cancer cell growth, colony formation, focal adhesion formation, and colocalized with Bcl-2 in vitro. Gene silencing from RNA interference of mutant paxillin led to reduction of cell viability. A murine in vivo xenograft model of A127T paxillin showed an increase in tumor growth, cell proliferation, and invasion. These results establish an important role for paxillin in lung cancer.
Chemistry of triangulo and linear triosmium cyclopentadienyl cluster compounds: the X-ray structures of [OS3(CO)10(η5-C5H5)Cl] and [OS3(CO)8(η5-C5H5)(µ-Cl)] (1986)

The cationic triangulo-complex [Os3(CO)10(η5-C5H5)][BF4] reacts with X–(X = H, Cl) to afford linear triosmium cluster compounds, [Os3(CO)10(η5-C5H5)X], characterised by X-ray crystallography for X = Cl; on heating [Os3(CO)10-(η5-C5H5)Cl] is converted into the triangulo-cluster [OS3(CO)8(η5-C5H5)(µ-Cl)] which, on the basic of an X-ray analysis, contains an unusually short chloride-bridged osmium–osmium distance.
Instrumental improvements and sample preparations that enable reproducible, reliable acquisition of mass spectra from whole bacterial cells (2015)

Fluctuations of ±15% in bacterial cell concentrations did not substantially compromise replicate spectra reproducibility.
Impact of Practical Skills on Academic Performance: A Data-Driven Analysis (2021)

Most academic courses in information and communication technology (ICT) or engineering disciplines are designed to improve practical skills; however, practical skills and theoretical knowledge are equally important to achieve high academic performance. This research aims to explore how practical skills are influential in improving students’ academic performance by collecting real-world data from a computer programming course in the ICT discipline. Today, computer programming has become an indispensable skill for its wide range of applications and significance across the world. In this paper, a novel framework to extract hidden features and related association rules using a real-world dataset is proposed. An unsupervised k-means clustering algorithm is applied for data clustering, and then the frequent pattern-growth algorithm is used for association rule mining. We leverage students’ programming logs and academic scores as an experimental dataset. The programming logs are collected from an online judge (OJ) system, as OJs play a key role in conducting programming practices, competitions, assignments, and tests. To explore the correlation between practical (e.g., programming, logical implementations, etc.) skills and overall academic performance, the statistical features of students are analyzed and the related results are presented. A number of useful recommendations are provided for students in each cluster based on the identified hidden features. In addition, the analytical results of this paper can help teachers prepare effective lesson plans, evaluate programs with special arrangements, and identify the academic weaknesses of students. Moreover, a prototype of the proposed approach and data-driven analytical results can be applied to other practical courses in ICT or engineering disciplines.
NeuroChat with Professor Steven Townsend (2019)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTNeuroChat with Professor Steven TownsendCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2019, 10, 4, 2082–2083Publication Date (Web):April 17, 2019Publication History Published online17 April 2019Published inissue 17 April 2019https://pubs.acs.org/doi/10.1021/acschemneuro.9b00169https://doi.org/10.1021/acschemneuro.9b00169editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1215Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (699 KB) Get e-AlertscloseSUBJECTS:Beverages,Chemical synthesis,Organic synthesis,Pharmaceuticals Get e-Alerts
Design considerations for 50G+ backplane links (2016)

The constantly increasing need for I/O bandwidth push electrical backplane links to data rates of 50Gb/s and above. Although board materials have improved significantly, backplane links are increasingly limited by signal attenuation while suffering from ISI, jitter, device noise and cross-talk. In this paper we summarize these limitations, and show possible directions to cope with them in order to further extend the achievable data rate.
Supplementary Figure 3 from Higher Frequencies of GARP<sup>+</sup>CTLA-4<sup>+</sup>Foxp3<sup>+</sup> T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality (2023)

&lt;p&gt;PDF file - 175K, Supplementary Figure 3. Effect of chronic viral infection or pre-treatment of HCC patients on GARP and CTL-A4 expression.&lt;/p&gt;
The Personal Assessment Tool: An experiment (2012)

We present the Personal Assessment Tool (PAT) aiming at making users aware of the impact of their behavior on the environment and helping them to reduce it. PAT targets print behavior in a corporate work environment. We have deployed PAT in our research center and describe this experiment along with preliminary findings and observations. From these findings we conclude that PAT definitely motivated the participating users to improve their print behavior. Nevertheless it also highlighted the constrained aspects of printing in a work environment calling for organizational changes of established work processes.
The Impact of the AFE BPF in Ultrasound Harmonic Imaging: An In-Vitro Phantom Study (2021)

Ultrasound harmonic imaging (UHI) employs nonlinear components in received echoes to improve image quality. Those harmonic signals are often weaker than the signal at the original transmission frequency. To maximize the received harmonic signals, a bandpass filter in the analog front-end (AFE BPF) can be used at an early stage to suppress the signals of less interest, enabling further amplification, which thus provides a better signal-to-noise ratio for the target harmonic. In this work, we present an in-vitro phantom study about the impact of an AFE BPF based on a prototype system for UHI, and we compare this against a digital filter or a pulse-inversion scheme. A 16-channel front-end with a programmable BPF and digitization is proposed to process ultrasound signals received from a capacitive micromachined ultrasonic transducer. Acoustic measurements based on a tissue-mimicking phantom show the feasibility of the AFE BPF approach. Compared to the other methods, the AFE BPF results in higher image contrast or relaxed requirements for the digitizer electronics.
Polypyridyl Ruthenium(II) Complexes with Tetrazolate-Based Chelating Ligands. Synthesis, Reactivity, and Electrochemical and Photophysical Properties (2007)

In this contribution, we report the synthesis, the chemical and photophysical characterization, and the study of the reactivity toward electrophiles of two mononuclear complexes of the type [Ru(bpy)2L]+ (bpy is 2,2'-bipyridyl), in which L is represented by the deprotonated form of 2-(1,H-tetrazol-5-yl)pyridine (L1) or 2-(1,H-tetrazol-5-yl)pyrazine (L2). The 1H and 13C NMR experiments that were performed on complexes RuL1 and RuL2 allowed us to establish that the tetrazolate moiety is bonded to the metal center via the N-1 nitrogen, while the coplanar arrangement adopted by the coordinated ligand upon coordination and the consequent interannular conjugation effect accounts for the unexpectedly low field resonance of the tetrazole carbon. The 13C NMR spectroscopy is also of fundamental importance to determine the chemo- and regioselectivity of the addition of a methyl group to RuL1 and RuL2, which takes place at the N-3 nitrogen of the five-membered ring. All these features were confirmed by the X-ray diffraction structures of RuL1 and of the methylated compounds RuL1Me and RuL2Me. Relative to these latter complexes, the presence of a methyl moiety does not cause any distortion from coplanarity of the coordinated tetrazolates. The redox properties of the complexes were investigated by cyclic voltammetry and indicated a quite different behavior between the pyrazinyl-tetrazolate and the pyridyl-tetrazolate complexes as the consequence of the higher electron-withdrawing character of the pyrazine ring. The study of the photophysical properties of the complexes also shows a significant diversity between the luminescent RuL1 and the rather poorly emissive RuL2. Interestingly, the methylated compounds RuL1Me and RuL2Me display radiative excited-state decays with longer lifetimes than their precursors; this feature indicates that methylation is a useful reaction for the tuning of the light emission performances of similar tetrazolate complexes. The synthesis and the characterization of a novel dinuclear complex of type [(bpy)2Ru-L3-Ru(bpy)2]2+, Ru(L3)Ru, where L3 is the bis-anion derived from bis-2,3-(1,H-tetrazol-5-yl)pyrazine, is also reported.
Anti-cancer Activity of Osmanthus matsumuranus Extract by Inducing G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma Hep G2 Cells (2015)

These results suggest that EEOM efficiently inhibits proliferation of HepG2 cells by inducing both G2/M arrest and apoptosis via intrinsic and extrinsic pathways, and EEOM may be used as a cancer chemopreventive agent in the food or nutraceutical industry.
Relationship of Emotional Behaviors Induced by Electrical Stimulation of the Hypothalamus to Changes in EKG, Heart, Stomach, Adrenal Glands, and Thymus (1996)

The relationships of hypothalamically elicited emotional behaviors to their accompanying pathophysiological effects were examined as a model of how complex "emotional behaviors" may be related to fundamental psychosomatic disorders. Twenty-two unanesthetized adult cats were studied. EKG alterations and histological changes in the heart, stomach, adrenal glands, and thymus were related to the specific stereotypical emotional behaviors that could be elicited by hypothalamic stimulation in tamed subjects. Restlessness, threat, and searching-biting behaviors were evoked by electrical stimulation of the anteromedial, ventromedial, and lateral hypothalamus, respectively. The occurrence of cardiac arrhythmias, ST and/or T (ST-T) changes in the EKG, histological damage to myocardium, gastric erosion, and adrenal hyperplasia were generally observed in the restlessness and threat groups but not in the searching-biting group. The pathophysiological effects were similar in the restlessness and threat groups with no specific EKG change or organ effect attributable to either site of stimulation. Hypothalamically elicited restlessness or threat behaviors in cats are each associated with cardiac, gastric, and adrenal pathophysiologies.
Keratinase of an anaerobic thermophilic bacterium Thermoanaerobacter sp. Strain 1004-09 isolated from a hot spring in the Baikal rift zone (2009)

A thermophilic anaerobic bacterial strain 1004-09 belonging to the genus Thermoanaerobacter and capable of growth on protein substrates such as albumin, gelatin, casein, and alpha and beta-keratins was isolated from the Urinskii hot spring (Barguzin river valley, Republic of Buryatia, Russia). A 150-kDa serine proteinase was revealed in the strain supernatant; it exhibited optimal activity at 60 degrees C and pH 9.3 and was capable of keratin hydrolysis. A number of characteristics for the strain 1004-09 keratinase were established including activation by SDS and NaCl and residual activity (15% to the activity of the intact protein) in the presence of 10% ethanol and acetone.