gebhart/patrepeval huggingface dataset:
Constitutive Delivery of Bovine β-Lactoglobulin to the Digestive Tracts of Gnotobiotic Mice by EngineeredLactobacillus casei (2006)

The gut microbiota is critical for maturation of the immune system. Recent evidence suggests that early establishment of lactobacilli in the intestinal microbiota, during neonatal colonization or by probiotic supplementation, could prevent the development of allergic disorders. Postnatal maturation of the gut immune system with allergen-producing lactobacilli colonizing the digestive tract could then affect the development of further allergic sensitization. In this paper, we describe construction of a recombinant Lactobacillus casei strain that can constitutively deliver bovine beta-lactoglobulin (BLG), a major cow's milk allergen, to the guts of gnotobiotic mice. The blg gene was inserted into the L. casei chromosome downstream of an endogenous promoter. BLG production was improved by fusing the propeptide LEISSTCDA (LEISS) to the BLG mature moiety. This led to a 10-fold increase in LEISS-BLG production compared to the production obtained without the propeptide and also led to enhanced secretion corresponding to 5% of the total production. After inoculation into germfree C3H/HeN mice, the genetic stability of the recombinant strain and in vivo BLG production were confirmed for at least 10 weeks. BLG stimulation of spleen cells from mice monoassociated with the BLG-producing lactobacilli induced secretion of the Th1 cytokine gamma interferon and, to a lesser extent, the Th2 cytokine interleukin-5. No BLG-specific immunoglobulin G1 (IgG1), IgG2a, or IgA was detected in sera or in fecal samples. These results suggest that gut colonization with allergen-producing lactobacilli could provide a useful model for studying the modulation of allergic disorders.
On the Leakage Resilient Cryptography in Game-Theoretic Settings (2016)

In this paper, we reevaluate leakage resilient cryptography from the viewpoint of game theory. We provide a general framework on leakage resilience in game theoretic setting and show that it is of each party's interest not to deviate from the protocol, i.e., their behavior is rational which assures them the highest incentive. We show that it is enough for a Public Key Encryption (PKE) scheme to be Computational Threat-Free Nash Equilibrium (CTFNE) for being leakage resilient. To be specific, CTFNE is not guaranteed if an internal state of a CCLA1 (Chosen Ciphertext with Leakage Attack)-secure Key Encapsulation Mechanism (KEM) of PKE is updated using a poor randomness with low-entropy. This work thus allows us for arguing about the strategic behavior of players in protocols where leakage is allowed.
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. (1988)

We tested the in vitro susceptibility of Candida albicans to three defensins from human neutrophilic granulocytes (HNP-1, 2, and 3), a homologous defensin from rabbit leukocytes (NP-1), and four unrelated cationic peptides. Although the primary amino acid sequences of HNP-1, 2, and 3 are identical except for a single amino-terminal amino acid alteration, HNP-1 and HNP-2 killed C. albicans but HNP-3 did not. C. albicans blastoconidia were protected from HNP-1 when incubations were performed in the absence of oxygen or in the presence of inhibitors that blocked both of its mitochondrial respiratory pathways. Neither anaerobiosis nor mitochondrial inhibitors substantially protected C. albicans exposed to NP-1, poly-L-arginine, poly-L-lysine, or mellitin. Human neutrophilic granulocyte defensin-mediated candidacidal activity was inhibited by both Mg2+ and Ca2+, and was unaffected by Fe2+. In contrast, Fe2+ inhibited the candidacidal activity of NP-1 and all of the model cationic peptides, whereas Mg2+ inhibited none of them. These data demonstrate that susceptibility of C. albicans to human defensins depends both on the ionic environment and on the metabolic state of the target cell. The latter finding suggests that leukocyte-mediated microbicidal mechanisms may manifest oxygen dependence for reasons unrelated to the production of reactive oxygen intermediates by the leukocyte.
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3. (2000)

B3 is a murine monoclonal antibody (mAb) that recognizes a LewisY carbohydrate antigen present on the surface of many carcinomas. An imaging and Phase I trial was performed to study the ability of 111In-mAb B3 to image known metastasis and determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), kinetics, and biodistribution of 90Y-mAb B3. Patients (n = 26) with advanced epithelial tumors that express the LewisY antigen were entered. All patients received 5 mCi of 111In-mAb B3 for imaging. 90Y-mAb B3 doses were escalated from 5 to 25 mCi in 5-mCi increments. 111In-mAb B3 and 90Y-mAb B3 were coadministered over a 1-h infusion. Definite tumor imaging was observed in 20 of 26 patients. Sites imaged included lung, liver, bone, and soft tissues. The MTD of 90Y-mAb B3 was determined to be 20 mCi. The DLTs were neutropenia and thrombocytopenia. Tumor doses ranged from 7.7 to 65.1 rad/mCi. 111In- and 90Y-mAb B3 serum pharmacokinetics (n = 23) were found to be similar. The amount of B3 administered (5, 10, and 50 mg) did not alter the pharmacokinetics. Bone marrow biopsies (n = 23) showed 0.0038+/-0.0016% of injected dose/gram for 111In-mAb B3 compared to 0.0046+/-0.0017% of injected dose/gram for 90Y-mAb B3 (P = 0.009). When given to patients with carcinomas that express the LewisY antigen, 111In-mAb B3 demonstrated good tumor localization. The MTD of 90Y-mAb B3 is 20 mCi, with myelosuppression as the DLT. Higher doses of radioactivity need to be delivered to achieve an antitumor effect. Humanized mAb B3 is being developed for evaluation in radioimmunotherapy. A clinical trial to explore the use of higher doses of 90Y-mAb B3 with autologous stem cell support is planned.
Generative Topic Embedding: a Continuous Representation of Documents (Extended Version with Proofs) (2016)

Word embedding maps words into a low-dimensional continuous embedding space by exploiting the local word collocation patterns in a small context window. On the other hand, topic modeling maps documents onto a low-dimensional topic space, by utilizing the global word collocation patterns in the same document. These two types of patterns are complementary. In this paper, we propose a generative topic embedding model to combine the two types of patterns. In our model, topics are represented by embedding vectors, and are shared across documents. The probability of each word is influenced by both its local context and its topic. A variational inference method yields the topic embeddings as well as the topic mixing proportions for each document. Jointly they represent the document in a low-dimensional continuous space. In two document classification tasks, our method performs better than eight existing methods, with fewer features. In addition, we illustrate with an example that our method can generate coherent topics even based on only one document.
Near-Net-Shape Ceramics by Reactive Processing (2006)

Since conventional production of high-temperature materials involves high investments and costly consumption of both energy and time, reaction engineering methodology combined with near-net shaping is often the answer to problems associated with the fabrication of advanced materials. Over the last decades, the number of different reaction–based processing methods for near-net-shaped ceramics has gradually increased. In this review, different reactive processing techniques and their potential for near-netshaping are treated, e.g. SHTS (self-supporting high temperature synthesis), the Lanxide method DIMEX®, reaction bonding (RB), reactive processing of Alumina-Aluminide Alloys (3A) and Al2O3-Al alloyed metal composites (3AMC). In addition to their potential for near-net shaping, other advantages to reactive processing routes are recognized to be reduced processing temperatures, reduced glassy phase formation at the grain boundaries, fine grained microstructures and improved mechanical strength. Since the exothermic reactions constitute the base for reactive processing of high quality materials in an economic way, control of these reactions is essential. The process flows are described together with characteristic features of process and materials. In addition, specific aspects of reaction-based synthesis will be illustrated with examples from own work in the area of reaction bonding of silicon nitride and alumina.
Multiple Interferon Regulatory Factor and NF-κB Sites Cooperate in Mediating Cell-Type- and Maturation-Specific Activation of the Human CD83 Promoter in Dendritic Cells (2013)

CD83 is one of the best-known surface markers for fully mature dendritic cells (mature DCs), and its cell-type- and maturation-specific regulation makes the CD83 promoter an interesting tool for the genetic modulation of DCs. To determine the mechanisms regulating this DC- and maturation-specific CD83 expression, chromatin immunoprecipitation (ChIP)-on-chip microarray, biocomputational, reporter, electrophoretic mobility shift assay (EMSA), and ChIP analyses were performed. These studies led to the identification of a ternary transcriptional activation complex composed of an upstream regulatory element, a minimal promoter, and an enhancer, which have not been reported in this arrangement for any other gene so far. Notably, these DNA regions contain a complex framework of interferon regulatory factor (IRF)- and NF-κB transcription factor-binding sites mediating their arrangement. Mutation of any of the IRF-binding sites resulted in a significant loss of promoter activity, whereas overexpression of NF-κB transcription factors clearly enhanced transcription. We identified IRF-1, IRF-2, IRF-5, p50, p65, and cRel to be involved in regulating maturation-specific CD83 expression in DCs. Therefore, the characterization of this promoter complex not only contributes to the knowledge of DC-specific gene regulation but also suggests the involvement of a transcriptional module with binding sites separated into distinct regions in transcriptional activation as well as cell-type- and maturation-specific transcriptional targeting of DCs.
The VCSEL-based array optical transmitter (ATx) development towards 120-Gbps link for collider detector: development update (2015)

A compact radiation-tolerant array optical transmitter module (ATx) is developed to provide data transmission up to 10Gbps per channel with 12 parallel channels for collider detector applications. The ATx integrates a Vertical Cavity Surface-Emitting Laser (VCSEL) array and driver circuitry for electrical to optical conversion, an edge warp substrate for the electrical interface and a micro-lens array for the optical interface. This paper reports the continuing development of the ATx custom package. A simple, high-accuracy and reliable active-alignment method for the optical coupling is introduced. The radiation-resistance of the optoelectronic components is evaluated and the inclusion of a custom-designed array driver is discussed.
Genetic engineering can either exacerbate or alleviate herbicide resistance (1997)

Sweeping generalizations promulgating dangers of herbicide-resistant crops and "superweeds" rarely meet scrutiny. Engineering resistance to little used, and especially multi-site herbicides can relieve selection pressures for evolution of resistance to the currently sometimes overused herbicide groups (e.g. inhibitors of ALS and ACCase). Engineering resistance to widely-used, single site herbicides into crops, increases evolutionary pressure for resistance. Such transfers could be justified for the control of parasitic weeds, where the alternatives are worse. Engineering resistance into crops that easily interbreed with weeds can sometimes be unwise. The rates of movements of such genes to weeds are unknown but gene transfer could be learnt using innocuous cases. There could still be advantages to resistant crops, without weed danger to other cropping situations (rice/red rice). Rational, case by case risk/cost/benefit analysis must replace irrational fear-striking generalizations, as agriculture can gain from many herbicide-resistant crops.
Effect of prostate gland weight on the surgical and oncological outcomes of extraperitoneal robot-assisted radical prostatectomy (2019)

The console time and estimated blood loss were significantly increased with a larger prostate size. However, there were no significant differences in the oncologic outcome and intraoperative complications, suggesting that EP-RARP requires meticulous bleeding control in patients with a prostate weighing > 75 g, and if appropriate management is implemented for blood loss intraoperatively, EP-RARP can be performed regardless of the prostate size.
High field effects on J/V characteristics in conducting polymers (2002)

We present a model to calculate the J/V characteristics for a single carrier conducting polymer sample including (i) distribution of traps in the energy space and (ii) reduction in the ionization energy of traps through the application of Poole Frenkel effect (PFE). The current-voltage characteristics of the polymers are influenced considerably by PFE because fields present in the polymers are very high. A comparison of our model with experimental results shows good agreement.
Influence of Surfactant Tail Branching and Organization on the Orientation of Liquid Crystals at Aqueous−Liquid Crystal Interfaces (2005)

We have examined the influence of two aspects of surfactant structure--tail branching and tail organization--on the orientational ordering (so-called anchoring) of water-immiscible, thermotropic liquid crystals in contact with aqueous surfactant solutions. First, we evaluated the influence of branches in surfactant tails on the anchoring of nematic liquid crystals at water-liquid crystal interfaces. We compared interfaces that were laden with one of three linear surfactants (sodium dodecyl sulfate, sodium dodecanesulfonate, and isomerically pure linear sodium dodecylbenzenesulfonate) to interfaces laden with branched sodium dodecylbenzenesulfonate. We carried out these experiments at 60 degrees C, above the Krafft temperatures of all the surfactants studied, and used the liquid crystal TL205 (a mixture of cyclohexane-fluorinated biphenyls and fluorinated terphenyls), which forms a nematic phase at 60 degrees C. Linear surfactants caused TL205 to assume a perpendicular orientation (homeotropic anchoring) above a threshold concentration of surfactant and parallel orientation (planar anchoring) at lower concentrations. In contrast, branched sodium dodecylbenzenesulfonate caused planar anchoring of TL205 at all concentrations up to the critical micelle concentration of the surfactant. Second, we used sodium dodecanesulfonate and a commercial linear sodium dodecylbenzenesulfonate to probe the influence of surfactant tail organization on the orientations of liquid crystals at water-liquid crystal interfaces. Commercial linear sodium dodecylbenzenesulfonate, which comprises a mixture of ortho and para isomers, has been previously characterized to form less ordered monolayers than sodium dodecanesulfonate at oil-water interfaces at room temperature. We found sodium dodecanesulfonate to cause homeotropic anchoring of both TL205 and 4'-pentyl-4-cyanobiphenyl (5CB, nematic at room temperature), whereas commercial linear sodium dodecylbenzenesulfonate caused predominantly planar and tilted orientations of both TL205 and 5CB. These results, when combined, lead us to conclude that (1) interactions between the aliphatic tails of surfactants and liquid crystals largely dictate the orientations of liquid crystals at aqueous-liquid crystal interfaces, (2) the interactions that orient the liquid crystals at these interfaces are sensitive to the branching and degree of disorder in the surfactant tails, and (3) differences in the chemical composition of TL205 and 5CB, most notably fluorination of TL205, lead to subtle differences in the orientations of these two nematic liquid crystals.
Supplementary Figure from Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma (2023)

Supplementary Figure from Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
Erratum to: Measurement of b hadron lifetimes in pp collisions at $$\sqrt{s} = 8$$ s = 8 $$\,\text {Te}\text {V}$$ Te (2018)

We have corrected Eqs. ( The published versions of Eqs. ( Below are the corrected equations:
NONDAMAGING PHOTOTHERMAL THERAPY FOR THE RETINA (2014)

Photothermal therapy using 577-nm PASCAL laser with Endpoint Management graphic user interface was safe, and it improved visual acuity and resolution of subretinal fluid in chronic central serous retinopathy. Lack of tissue damage allows periodic retreatment without cumulative scaring, characteristic to conventional photocoagulation. This technique should be tested in the treatment of other macular disorders and may offer an alternative to conventional laser coagulation of the macula and to anti-vascular endothelial growth factor pharmacological treatments of macular diseases.
A Broadband Millimeter-Wave Continuous-Mode Class-F Power Amplifier Based on the Deembedded Transistor Model (2020)

In this letter, a broadband millimeter-wave (mm-wave) continuous-mode Class-F power amplifier (PA) based on the deembedded transistor model is proposed for the fifth-generation (5G) applications. To design the output matching network at the intrinsic current-generator plane, an S-parameter fitting method is proposed to extract the parasitic parameters of nonpackaged transistors over a wide frequency range. The PA is implemented in the 0.13-μm SiGe BiCMOS process, which occupies only 0.42 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . By controlling the even and odd harmonics impedance, the PA achieves a 78.2% -3-dB small-signal gain fractional bandwidth from 21.1 to 48.2 GHz. The -1-dB P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> bandwidth covers 21-43 GHz (68.8% fractional bandwidth) and the saturated output powers are 17.2-18.1 dBm. Meanwhile, the designed PA provides a 24.1%-32.1% peak power-added efficiency (PAE) over the band.
Joint Acoustic Localization and Dereverberation Through Plane Wave Decomposition and Sparse Regularization (2019)

Acoustic source localization and dereverberation are formulated jointly as an inverse problem. The inverse problem consists of the approximation of the sound field measured by a set of microphones. The recorded sound pressure is matched with that of a particular acoustic model based on a collection of plane waves arriving from different directions at the microphone positions. In order to achieve meaningful results, spatial and spatio-spectral sparsity can be promoted in the weight signals controlling the plane waves. The large-scale optimization problem resulting from the inverse problem formulation is solved using a first order optimization algorithm combined with a weighted overlap-add procedure. It is shown that once the weight signals capable of effectively approximating the sound field are obtained, they can be readily used to localize a moving sound source in terms of direction of arrival (DOA) and to perform dereverberation in a highly reverberant environment. Results from simulation experiments and from real measurements show that the proposed algorithm is robust against both localized and diffuse noise exhibiting a noise reduction in the dereverberated signals.
Feedback Generation for CoMP Transmission in Unsynchronized Networks with Timing Offset (2014)

Coordinated multipoint (CoMP) transmission is a promising technique in long term evolution (LTE) systems to provide coverage and broadband communication for cell edge user equipments (UEs). However, as signals from multiple transmitters may reach the UE at different times, CoMP networks might experience high time offsets, leading to significant performance loss in closed-loop transmission. In this paper we show that spacing between reference signals (RSs) imposes a phase offset on the transmit covariance matrix in presence of timing offset (TO), affecting the feedback generation. The promised advantages of closed-loop CoMP transmission vanish in presence of TO due to improper precoding matrix index (PMI) selection. Keeping the phase shift close to zero, reliable PMI selection can be guaranteed and as a result near optimum performance is achieved for closed-loop CoMP transmission in unsynchronized networks with TO present.
Xerox site report : Four TREC-4 tracks (1995)

this document sample than one would expect by chance. The terms are selected according to a binomial likelihood ratio test [10], comparing their occurrence in the first 20 documents to their occurrence in the rest of the collection. The selected terms are then weighted in proportion to the significance of their occurrence in the sampled documents. Since it uses the baseline results, this run may also be affected by the programming error described above. query set base infl infl-np expand all Q1-25 0.454 0.484 0.492 0.467 Q26-50 0.174 0.204 0.212 0.267 20 Q1-25 0.718 0.718 0.722 0.722 Q26-50 0.306 0.354 0.378 0.402 Table 8: Average precision at all relevant docs (all) and average precision at 20 docs (20) for Spanish queries. The corrected Spanish performance figures are presented in Table 8. We include four different runs: (1) base = stop list but no morphological analysis, (2) infl = text lemmatized (stemmed) with inflectional morphology, (3) infl-np = noun phrase weight doubled, and (4) expand = query expansion. The uncorrected performance figures for infl-np and expand on Q26-50 (corresponding to our submitted runs) are 0.190/0.366 and 0.238/0.380 respectively. We present separate results for queries 1-25 (used for TREC-3) and 26-50 (used for TREC-4) since the former are substantially longer, and we note that the results reflect the difference in length. We find that lemmatization using inflectional morphology helps in most cases, making a 3-5% absolute difference in performance. However, when the queries are long and the user is examining fewer than 20 documents, there is no improvement. These conclusions agree with the results obtained for English [13], although the Spanish inflectional morphology is somewhat more effective than its English counterpart. Doubling ...
Temperature‐Dependent Surface‐Enrichment Effects of Imidazolium‐Based Ionic Liquids (2013)

Abstract We present the first systematic study of the influence of temperature on the degree of surface enrichment of 1‐alkyl‐3‐methylimidazolium‐based ionic liquids (ILs). Using angle‐resolved X‐ray photoelectron spectroscopy, we demonstrate that the degree of surface enrichment strongly decreases with increasing temperature for all the studied ILs. For ILs with the same cation, but different anions, [C 8 C 1 Im]Br, [C 8 C 1 Im][TfO] and [C 8 C 1 Im][Tf 2 N], no significant differences of the temperature‐induced partial loss of surface enrichment are found. Measurements for [C 4 C 1 Im][TfO], [C 8 C 1 Im][TfO] and [C 18 C 1 Im][TfO] indicate a small effect of the chain length. For [C 18 C 1 Im][TfO], a continuous decrease of alkyl surface enrichment is found with increasing temperature, with no abrupt changes at the phase‐transition temperature from the smectic A to the isotropic phase, indicating that the surface enrichment is not affected by this phase transition.