gebhart/patrepeval huggingface dataset:
Domain Wall Based Spin-Hall Nano-Oscillators (2019)

In the last decade, two revolutionary concepts in nanomagnetism emerged from research for storage technologies and advanced information processing. The first suggests the use of magnetic domain walls in ferromagnetic nanowires to permanently store information in domain-wall racetrack memories. The second proposes a hardware realization of neuromorphic computing in nanomagnets using nonlinear magnetic oscillations in the gigahertz range. Both ideas originate from the transfer of angular momentum from conduction electrons to localized spins in ferromagnets, either to push data encoded in domain walls along nanowires or to sustain magnetic oscillations in artificial neurones. Even though both concepts share a common ground, they live on very different timescales which rendered them incompatible so far. Here, we bridge both ideas by demonstrating the excitation of magnetic auto-oscillations inside nanoscale domain walls using pure spin currents. This Letter will shed light on the current characteristic and spatial distribution of the excited auto-oscillations.
Probabilistic Solar Irradiance Forecasting by Conditioning Joint Probability Method and Its Application to Electric Power Trading (2018)

This study presents a method for probabilistic forecasting of solar irradiance based on the joint probability distribution function (PDF) of irradiance predicted by numerical weather prediction (NWP) and irradiance observed. Multidimensional kernel density estimation was used to construct this joint PDF. The probabilistic forecast is obtained by deriving a conditional PDF given a current NWP by using the Bayes rule. The proposed method can naturally handle the nonlinear nature of the relation between observed and predicted irradiance. The method showed better statistical performance in terms of the continuous ranked probability score, reliability, and sharpness than an existing probabilistic forecasting method based on ensemble NWP. Simulation of solar power trading based on pricing of an actual electric power market also confirmed that the proposed method results in greater profit by suppressing penalties imposed due to overbidding.
A Novel Approach for Frequency Chirp ToF Estimation Utilizing Analog Hilbert Transformation (2021)

Estimating the focal point of a received pulse for time delay or distance measurement is an essential challenge in a variety of today’s radio applications. In the scope of this paper a completely new concept for FMCW chirp pulse detection will be presented. Contrasting traditional correlation techniques for time delay estimation which stem on increasing bandwidth for better resolution, the presented method is based on the acceleration of phase change and is therefor not ultimately dependent on the allocated bandwidth. After introducing the theoretical concept of using an analog Hilbert transformer for estimation of the focal point of a frequency chirp pulse, it will then be discussed how these properties may be exploited to make accurate time-of-flight measurements maintaining high resolution whilst operating at comparably narrow bandwidths. Furthermore a clear mathematical description for modeling of the system will be derived. Finally extensive simulation results will be presented explaining the detector concept in depth.
Resveratrol Inhibits Uveal Melanoma Tumor Growth via Early Mitochondrial Dysfunction (2008)

These data suggest that resveratrol can inhibit tumor growth and can induce apoptosis via the intrinsic mitochondrial pathway and that by further increasing bioavailability of resveratrol the potency of the drug can be increased, leading to tumor regression. The nontoxic nature of the drug at levels needed for therapy make resveratrol an attractive candidate for the treatment of uveal melanoma.
Factors Affecting Successful Isolation of Human Corneal Endothelial Cells for Clinical Use (2013)

Corneal transplantation is a common transplant procedure used to improve visual acuity by replacing the opaque or distorted host tissue with clear healthy donor tissue. However, its clinical utility is limited due to a lack of donor supply of high-quality corneas. Bioengineered neocorneas, created using an expandable population of human donor-derived corneal endothelial cells (HCECs), could address this shortage. Thus, the objective of this study was to evaluate HCEC sourcing with various isolation methods, including enzymatic digestion, culture medium components, and adhesive proteins. HCECs were obtained from corneas obtained from various aged donors after endothelial keratoplasty. Under a dissection microscope, the Descemet's membrane, including the attached corneal endothelium, was stripped from the stroma, and the cells were isolated and expanded by explant culture or by enzymatic digestion with enzymes such as collagenase II, dispase, or trypsin. In order to improve the initial cell attachment, tissue culture plates were coated with collagen IV, fibronectin, or fibronectin-collagen combination coating mix (FNC) before cell plating. We were able to successfully obtain HCECs from 32% (86/269) of donor corneas. Donor age and isolation method influenced the characteristics of the resulting in vitro HCEC culture. Under all conditions tested, FNC-coated plates showed higher quality cultures than the other coatings tested. These results suggest that donor age and HCEC isolation methodology are the two factors that most directly affect the quality of the resulting HCEC culture in vitro. These factors should guide the methodological development for the clinical expansion of HCECs for the generation of bioengineered neocorneas.
Experimental evidence for hole transport limited intensity modulation response in quantum well lasers (1993)

Direct experimental evidence is presented to show that it is the hole transport across wide separate confinement heterostructures and not the electron quantum capture that leads to the low frequency rolloff in the intensity modulation response of quantum well lasers.
Supplementary Figure 6 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15 (2023)

&lt;p&gt;PDF file - 275KB, GDF15/MIC-1 serum levels correlate with "responder" tumor growth.&lt;/p&gt;
Abstract A77: Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer (2016)

Abstract Methods: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy that affects 44,000 individuals yearly in the US. The list of agents active against PDAC is limited. We explored in an unbiased fashion the clinically available drugs to identify novel cytotoxics using new physiological models for PDAC including cells rapidly expanded in vitro from surgical or xenografted tumors (PDX). Results: Not unexpectedly, only a small minority of agents showed activity against pancreatic carcinoma cells in vitro. Among these, transcriptional repressors and drugs interfering with protein folding and biosynthesis ranked as most cytotoxic. Triptolide, a covalent inhibitor of the ERCC3, a bifunctional regulator of transcription and DNA repair, was most consistently effective in vitro and highly effective in vivo, causing prolonged complete regression in multiple PDX models. Importantly, triptolide showed superior activity in MYC-amplified PDX models, suggesting a critical role for ERCC3 in this subset. Triptolide elicited rapid and profound depletion of MYC oncoprotein, a transcriptional co-factor for ERCC3. Expression of ERCC3 was MYC-dependent, while resistance to triptolide was associated with elevated ERCC3 and MYC expression. Furthermore, high ERCC3 mRNA level was associated with decreased survival of PDAC patients. Conclusions: These findings provide preclinical evidences for transcriptional vulnerability in PDAC via ERCC3 targeting and a new mechanistic approach for disruption of MYC-dependent pancreatic cancers. Citation Format: Igor Astsaturov, Sandra A. Jablonski, Yan Zhou, Ilya Serebriiskii, Paz Keren, Louis M. Weiner, Erica Golemis, Vladimir Khazak.{Authors}. Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr A77.
Markers of abnormal tissue deformation and fibrosis in remote myocardium following acute myocardial infarction: a comparison of diabetics versus non-diabetics performed using spatially matched 4D strain and native T1 mapping (2016)

Markers of abnormal tissue deformation and fibrosis in remote myocardium following acute myocardial infarction: a comparison of diabetics versus non-diabetics performed using spatially matched 4D strain and native T1 mapping Alessandro Satriano, Kate Fenwick, Dexter D Waters, Haris Vaid, Yoko Mikami, Naeem Merchant, Carmen P Lydell, Andrew G Howarth, Teresa A Whitman, Derek V Exner, Bobak Heydari, Nowell M Fine, James A White
Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop (2016)

In November 2015, the CALYM Carnot Institute held a 2-d workshop to discuss the current and future development of immunomodulatory antibodies for the treatment of lymphoma. Highlights from the workshop are presented in this article.
Table S3 from EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells (2023)

&lt;p&gt;Selected functional pathways affected by changes in EMP2 expression.&lt;/p&gt;
Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites (2000)

Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) between 2.5- and 10-fold lower than that of a wild-type control. Mutations in the RT domain that had previously been associated with antiretroviral resistance were not shared by these strains. We have analyzed by logistic regression 46 variable amino acid sites in RT for their effect on susceptibility and have identified two novel sites influencing susceptibility to NNRTIs: amino acids 135 and 283 in RT. Eight different combinations of amino acids at these sites were observed among these patients. These combinations showed a 14-fold range in mean susceptibility to both nevirapine and delavirdine. In vitro mutagenesis of the control strain combined with a phenotypic assay confirmed the significance of amino acid variation at these sites for susceptibility to NNRTIs.
Greedy algorithms in coding theory (2002)

A wide class of problems in coding theory are dealt with using a greedy algorithm due to Stein (1974) and Lovasz (1975). Some examples, including constructing covering codes, codes for conflict resolution, separating systems, source encoding with distortion, etc., are given a unified treatment.
Enhanced mortality of Bemisia tabaci nymphs by Isaria javanica combined with sublethal doses of chemical insecticides (2018)

Abstract The aim of this current study was to evaluate the mortality of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) nymphs by the combination between the entomopathogenic fungus Isaria javanica (Friedrichs &amp; Bally) Samson &amp; Hywel‐Jones and synthetic chemical insecticides. The bioefficacy of I. javanica and the insect growth regulators named spiromesifen and buprofezin was tested alone and in combination against B. tabaci nymphs under screenhouse conditions. The in vitro compatibility between these two control agents was previously assessed under laboratory conditions. The sublethal concentration ( LC 25 ) of these insecticides towards second‐instar nymphs was determined and then mixed with the fungal treatments to investigate the type of interaction. All I. javanica isolates at 5 × 10 7 conidia/ml inflicted nymphal mortality by up to 62.4%. The insecticides did not influence the germination and mycelial growth of the selected I. javanica isolate CG 1282. In general, the insecticide–fungus combinations increased nymphal mortalities in comparison with their single counterparts. Combinations with the fungus and buprofezin or spiromesifen augmented nymphal mortality by 10% and 24%, respectively, in comparison with the fungus alone. Additive interaction was found with the combination of the I. javanica CG 1282 at 1 × 10 6 conidia/ml and spiromesifen at 1.56 ppm, and additive and synergistic interactions were achieved with the fungus at 5 × 10 6 conidia/ml and spiromesifen at 3.12, 6.25 and 12.5 ppm. Additive interactions were also observed from mixtures of fungus at 5 × 10 6 and buprofezin at 3.12 and 6.25 ppm. Only combinations of I. javanica with spiromesifen reduced to some extent the mycosis on dead nymphs. The joint action of I. javanica with sublethal doses of these insecticides may be a promising tool to assist in the integrated management system for B. tabaci .
The Structural Chemical Database of the All-Russian Institute for Scientific and Technical Information, Russian Academy of Sciences. An Autonomous System for Structural Searches (2018)

A system is described that provides autonomous searching for information by various characteristics of chemical compounds in the Structural Chemical Database of the All-Russian Institute for Scientific and Technical Information of the Russian Academy of Sciences. Examples of a search and the prospects for further development of the system are given.
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol (2011)

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on total cholesterol (TC) with a combined P-value of 4.79×10(-9). There were two potential candidate genes in the region, PCDH7 and CCKAR, with differential expression levels for rs6448771 genotypes in adipose tissue. The effect of WHR on TC was strongest for individuals carrying two copies of G allele, for whom a one standard deviation (sd) difference in WHR corresponds to 0.19 sd difference in TC concentration, while for A allele homozygous the difference was 0.12 sd. Our findings may open up possibilities for targeted intervention strategies for people characterized by specific genomic profiles. However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus.
SP491EFFECTS OF DECREASING DIALYSIS FLUID FLOW RATE ON DIALYSIS EFFICACY AND INTERDIALYTIC WEIGHT GAIN IN CHRONIC PATIENTS WITH HEMODIALYSIS - FLUGAIN Study (2018)

INTRODUCTION AND AIMS: Mixed Haemodiafiltration (Mixed HDF), an infusion technique with simultaneous infusion at pre-and post-dilution sites of the hemofilter, has been introduced in the recent years to promote achievement of the highest convective volume (CV) while avoiding the drawbacks of the traditional HDF infusion modes, accounting that high CV and solute removal may substantially improve survival of dialysis patients. Mixed HDF was implemented since 2011 in 21 Centers of the NephroCare Dialysis Network in Italy. Results of its application in terms of uremic toxins removal and survival of a cohort of patients followed for 5 years are presented here. METHODS: 360 patients (101F,259M), aged 64613, range 23-88, on Mixed HDF for at least 6 months in 21 Centers from September 2012 to September 2017 were selected after excluding those with previuos longer vintage in other techniques, which was post-HDF in 69% and high-flux HD in 31%. Lab analyses were extracted from the EuCliD database and averaged by month. Blood flow (QB), CV, Kt/V, treatment time (t) and body weight (BW) were recorded on-line at each session and averaged per month. Kaplan Meier survival analysis was performed as overall data-period and by class of age (1, <54; 2,55-64; 3,65-74; 4, >75y). RESULTS: The mean observation period was 35,6624,9 months, range 6-78. Mean session time was 23967 min, dry BW 73613 kg at the start of follow-up. Trends of QB, CV, markers of small (Kt/V) and middle molecule removal (Beta2-microglobulin level and Reduction Ratio), nutritional and anaemia status throughout the follow-up are reported in Table Four-years Cumulative survival, overall and by AgeClass (Log Rank test 35,6, P<0.001 for age >75y) are shown in Fig. Deaths during the 4-year follow up were 34.
ChemInform Abstract: Highly Magnetic Core—Shell Nanoparticles with a Unique Magnetization Mechanism. (2011)

Abstract Highly magnetic nanoparticles Fe@Fe 3 O 4 for biomedical use are prepared by thermal decomposition of Fe(CO) 5 in the presence of oleylamine followed by exposure to air and addition of Fe‐oleate complexes (300 °C, 1 h).
Association of tumor perivascular desmin expression with survival in patients with sunitinib-treated renal carcinoma. (2013)

11097 Background: The introduction of tyrosine kinase inhibitors has markedly improved the outcome for patients with metastatic renal carcinoma (mRCC), but lack of reliable response-predictive markers makes it difficult to individualize treatment. Pericytes surround endothelial cells of capillaries and regulate vessel function. Associations between pericyte marker expression and response to sunitinib have not been well characterized. Methods: A tissue micro array with samples from 67 mRCC patients ( 34 males, 33 females, age 42 – 84) treated at Dept. of Oncology, Karolinska University Hospital where constructed from primary tumors. All patients included had received at least one course with the tyrosine kinase receptor inhibitor sunitinib. Data of treatment, progression free survival and overall survival was collected in a clinical registry. Tissues were double-stained with the endothelial cell marker CD 34 and either of three pericyte markers desmin, PDGF beta receptor and alpha smoth muscle actin (ASMA). By semi-quantitative visual scoring, the perivascular staining of these markers was evaluated and cases dichotomized into negative/low- or positive/high-expressing groups. Results: For patients with desmin positive/high vessels ( n = 12), median PFS where 5.0 months (2.9 – 7.1, 95% CI) vs 7.0 months for patients with desmin negative/low vessels (n = 55, 3.8 – 10.2, 95% CI, Mantel Cox log rank test p&lt;0.02). The median OS in the desmin-positive/high group was 24 months ( 7 – 41, 95% CI) vs 46 months in the negative/low group ( 34 – 58, 95 % CI, Mantel Cox log rank test p&lt;0.014). No significant associations were seen between PFS or OS and the expression of perivascular PDGF beta receptor or ASMA. Conclusions: Metastatic RCC displays a clinically relevant variation in perivascular desmin expression which is associated with survival in sunitinib-treated patients. Future studies are warranted which further explores the prognostic and/or response-predicative capacity of this novel candidate renal cell cancer biomarker.
Rebuttal on Identification of Two Triterpenoids in Solid Wastes from Olive Cake (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCorrespondenceNEXTRebuttal on Identification of Two Triterpenoids in Solid Wastes from Olive CakeJuan L. RamosView Author Information Consejo Superior de Investigaciones Cientificas, Estacion Experimental del Zaidin, Profesor Albareda 1, 18008 Granada, SpainCite this: J. Agric. Food Chem. 1998, 46, 8, 3401Publication Date (Web):July 18, 1998Publication History Received20 March 1998Published online18 July 1998Published inissue 17 August 1998https://pubs.acs.org/doi/10.1021/jf9803435https://doi.org/10.1021/jf9803435article-commentaryACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views183Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (17 KB) Get e-AlertscloseSUBJECTS:Alkyls,Hydrocarbons,Lipids,Plant derived food,Wastes Get e-Alerts
Distribution of a rat galanin receptor mRNA in rat brain (1996)

In situ hybridization histochemistry has been employed to determine the distribution of the mRNA encoding a recently cloned rat galanin receptor (rGalR1). The galanin receptor mRNA has been found to be discretely localized in rat brain. The most intense hybridization signals were found over neurons in the nucleus of the lateral olfactory tract, in the ventral posterior hippocampus, and in the lateral external subdivision of the parabrachial nucleus. A number of other brain regions also contain significant hybridization signals, including the hypothalamus, brain stem and spinal cord. The localization of rGalR1 mRNA indicates that this receptor may play a role in the varied functions ascribed to GAL, among them feeding, cognition and modulation of sensory information.
Microstructure Evolution and Dielectric Properties of Ultrafine Grained BaTiO 3 ‐Based Ceramics by Two‐Step Sintering (2011)

The base‐metal electrode multilayer ceramic capacitors for future application require much thinner dielectric layers (&lt;1 μm). Therefore, the grain size and uniformity of dielectric ceramics should be effectively controlled. In this paper, a two‐step sintering (TSS) method has been utilized to prepare the ultrafine‐grained X7R BaTiO 3 ceramics in reducing atmosphere with the average grain size below 200 nm. And the influence of TSS schedule on the microstructure (such as bulk density, grain size) and dielectric properties is discussed in detail. Furthermore, the development of core–shell structure and corresponding temperature coefficient of capacitance characteristics during the intermediate stage of TSS process has been systematically investigated.