gebhart/patrepeval huggingface dataset:
THE ROLE OF SEROTONERGIC MECHANISMS IN SNEEZE- INDUCED URETHRAL CONTINENCE REFLEX IN RATS (2008)

You have accessJournal of Urology1 Apr 2008THE ROLE OF SEROTONERGIC MECHANISMS IN SNEEZE- INDUCED URETHRAL CONTINENCE REFLEX IN RATS Minoru Miyazato, Yasuhiro Kaiho, Kimio Sugaya, Yoshihide Ogawa, Michael B Chancellor, William C de Groat, and Naoki Yoshimura Minoru MiyazatoMinoru Miyazato More articles by this author , Yasuhiro KaihoYasuhiro Kaiho More articles by this author , Kimio SugayaKimio Sugaya More articles by this author , Yoshihide OgawaYoshihide Ogawa More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , William C de GroatWilliam C de Groat More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61676-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "THE ROLE OF SEROTONERGIC MECHANISMS IN SNEEZE- INDUCED URETHRAL CONTINENCE REFLEX IN RATS." The Journal of Urology, 179(4S), p. 570 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 570 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Minoru Miyazato More articles by this author Yasuhiro Kaiho More articles by this author Kimio Sugaya More articles by this author Yoshihide Ogawa More articles by this author Michael B Chancellor More articles by this author William C de Groat More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences (2003)

Here we present recent data indicating that the present view of the interstitium as a passive fluid reservoir has to be revised. The connective tissue cells and extracellular matrix have a role in the control of P(if) and a fundamental role in the rapid development of edema in burns and in the initial swelling in inflammation by generating a lowering of interstitial fluid pressure. In this process, the beta1-integrin system seems to provide a common pathway by which the cells can lower as well as raise P(if). Inflammatory swelling can be reversed by endo- and exogenous substances, thereby suggesting that the connective tissue can serve as a novel target for pharmacological intervention. Furthermore, the new knowledge in interstitial physiology on means to reduce interstitial fluid pressure may be of importance for drug delivery into solid tumors, where a high P(if) limits the uptake of therapeutic agents.
Infection of brain pericytes underlying neuropathology of COVID-19 patients (2021)

Abstract A wide range of neurological manifestations have been associated with the development of COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological symptomatology is still largely unexplored. Here, we used state-of-the-art multiplexed immunostaining of human brains ( n = 6 COVID-19, median age = 69,5 years; and n = 7 control, median age = 68 years), and demonstrated that expression of the SARS-CoV-2 receptor ACE2 is restricted to a subset of neurovascular pericytes. Strikingly, neurological symptoms were exclusive to, and ubiquitous in, patients that exhibited moderate to high ACE2 expression in peri-vascular cells. Viral particles were identified in the vascular wall and paralleled by peri-vascular inflammation, as signified by T cell and macrophage infiltration. Furthermore, fibrinogen leakage indicated compromised integrity of the blood-brain barrier. Notably, cerebrospinal fluid from an additional 16 individuals ( n = 8 COVID-19, median age = 67 years; and n = 8 control, median age = 69,5 years) exhibited significantly lower levels of the pericyte marker PDGFRβ in SARS-CoV-2-infected cases, indicative of disrupted pericyte homeostasis. We conclude that pericyte infection by SARS-CoV-2 underlies virus entry into the privileged central nervous system space, as well as neurological symptomatology due to peri-vascular inflammation and a locally compromised blood-brain barrier.
Photoluminescence and electroluminescence from copper doped zinc sulphide nanocrystals/polymer composite (1998)

Cu-doped ZnS nanocrystals were prepared in an inverse microemulsion at room temperature as well as under a hydrothermal condition. X-ray diffraction analysis showed that the diameter of the Cu-doped ZnS nanocrystals particles was about 9 nm. These particles showed a strong photoluminescence intensity and a broad emission band from 490 to 530 nm. The half-width of emission was about 60 nm. Cu-doped ZnS nanocrystals/polymethylmethacrylate composite as a light-emitting layer was used to fabricate a single layer structure electroluminescent device which had low turn on voltage (less than 5 V). The green light of electroluminescence was observed at room temperature. The electroluminescence and photoluminescence spectra were nearly identical at room temperature.
Supplementary Figures 1-8 from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency (2023)

&lt;p&gt;Figure S1A. Binding affinities of OMP-59R5 to human (h) Notch1-4 receptors; Figure S1B. Alignment of the EGF repeats 10-15 of Notch2 and 9-14 of Notch3 from human (h), cynomolgus monkey (cyno), and mouse (m); Figure S2. Human NOTCH1, NOTCH2 and NOTCH3 gene in patient-derived primary xenograft tumors; Figure S3. Effect of OMP-59R5 on tumor growth of individual animals in OMP-PN8 and OMP-PN17 xenografts (from Figure 2); Figure S4A. Effect of OMP-59R5 on goblet cells; Figure S4B. Effect of OMP-59R5 on teeth in NOD/SCID mice; Figure S5. Effect of OMP-59R5 on (a) gene expression, (b) Human vimentin IHC (c) Western blot of Notch3 transmembrane domain (TM) and Notch3 intracellular domain (ICD) protein levels and (d) Quantitation of Notch1 ICD staining intensity levels in pancreatic xenograft tumors; Figure S6A. Effect of OMP-59R5 in combination with gemcitabine or gemcitabine/nab-paclitaxel in OMP-PN8 xenograft tumors; Figure S6B. Effect of OMP-59R5 in combination with gemcitabine/nab-paclitaxel on body weight change in OMP-PN8 xenograft tumor-bearing NOD/SCID mice (from Figure 4B); Figure S6C. Activity of OMP-59R5 in combination with nab-paclitaxel plus gemcitabine in OMP-PN16; Figure S8A. Perfused vessels are associated with the presence of desmin; Figure S8B. Quantification of perfused blood vessels; Figure S8C. Targeting DLL4/Notch signaling and Notch2/3 signaling has opposite effect on tumor stroma/vasculature; Figure S7A. Anti-tumor effect of OMP-59R5 in SCLC tumors; Figure S7B. Effect of OMP-59R5 on Notch3 ECD and Notch3 ICD expression in UM-PE13 xenograft tumors; Figure S7C. Limiting Dilution Assay&lt;/p&gt;
Symmetric Cryptography (Dagstuhl Seminar 16021) (2016)

From 10.01.2016 to 15.01.2016, the Seminar 16021 in Symmetric Cryptography was held in Schloss Dagstuhl-Leibniz Center for Informatics. It was the fifth in the series of the Dagstuhl seminars "Symmetric Cryptography" held in 2007, 2009, 2012, and 2014. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations were given during the seminar. The first section describes the seminar topics and goals in general.
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Anti-Tuberculosis Drug Bedaquiline (2023)

Bedaquiline (BDQ) is an important drug for treating multidrug-resistant tuberculosis (MDR-TB), a worldwide disease that causes more than 1.6 million deaths yearly. The current synthetic strategy adopted by the manufacturers to assemble this molecule relies on a nucleophilic addition reaction of two complex starting materials, but suffers from low conversion and no stereoselectivity, which subsequently increases the cost of manufacturing BDQ. M4ALL has developed a new approach to this process that not only allows high conversion of starting materials, but also results in good diastereo- and enantioselectivity towards the desired BDQ stereoisomer. A variety of chiral lithium amides derived from amino acids were studied, and it was found that lithium (R)-2-(methoxymethyl)pyrrolidide, obtained from D-proline, results in high assay yield of the syn-diastereomer pair (82 %) and with considerable stereocontrol (d.r. = 13.6:1, e.r. = 3.6:1, 56 % ee) providing bedaquiline in up to 64 % assay yield before purification steps towards the final API. This represents a considerable improvement in the BDQ yield compared to previously reported conditions and could be critical to further lowering the cost of this life-saving drug.
ChemInform Abstract: Stilbenoid Dimers: Dissection of a Paracyclophane Chromophore. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Oxygen lowers intraocular pressure. (1980)

A significant decrease in intraocular pressure was demonstrated in 14 patients as atmospheric pressure was increased at intervals of 0.5 atmospheric pressure up to 3 atmospheres within a hyperbaric chamber. Nine of these patients had the identical protocol repeated in room air at atmospheric pressure without a significant change in intraocular pressure. Administration of 100% O2 at 15 L/min by partial rebreathing face mask to these patients using the same protocol at atmospheric pressure resulted in a significant decrease in intraocular pressure. The results in the oxygen and hyperbaric groups were not statistically different. While in the hyperbaric chamber, scleral rigidity increased uniformly, outflow facility decreased significantly, and keratometry readings remained unchanged. A significant decrease in intraocular prssure occurred in 20 rabbits that received 100% oxygen by partial rebreathing face mask for 180 minutes. Arterial blood gases were obtained at 0.90, and 180 min in seven rabbits. The pH and pCO2 did not change significantly; however, pO2 was markedly elevated. Increased oxygen concentration was felt to be responsible fot the decrease in intraocular pressure and the changes in other parameters observed in patients and rabbits.
MEMS high resolution 4-20 mA current sensor for industrial I/O applications (2004)

An isolated MEMS-based 4-20 mA current sensor device has been developed for industrial automation applications. This device consists of a current carrying suspension that is electrically isolated, yet mechanically coupled to a bank of capacitive comb fingers. Under the presence of a magnetic field, the sense current produces a Lorentz force that laterally deflects the device. The deflection is capacitively detected. Using various flexure designs to tune the sensitivity and current capacity, this device can be made highly linear with a sensitivity of 0.25 /spl mu/A.
Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder (2022)

<b><i>Trial Registration:</i></b> ClinicalTrials.gov Identifier: NCT04019704.
Liquid crystal polymer full-stokes division of focal plane polarimeter (2012)

A division-of-focal-plane polarimeter based on a dichroic dye and liquid crystal polymer guest-host system is presented. Two Stokes polarimeters are demonstrated: a linear Stokes and the first ever Full-Stokes division-of-focal-plane polarimeter. The fabrication, packaging, and characterization of the systems are presented. Finally, optimized polarimeter designs are discussed for future works.
Calculation of Optical and Dielectric Anisotropy of Nematic Liquid Crystals (1998)

The optical birefringence (Δ n ) and dielectric anisotropy (Δ ε ) of nematic liquid crystals were calculated using the well-known theories of Vuks and Maier-Meier, respectively. The molecular dipole moments and polarizabilities needed for the estimation were taken from semiempirical AM1 calculations. The calculated values are in good agreement with the experimental results for the investigated compounds having different core structures and polar substituents.
Effect of Postdeposition Annealing Temperatures on Electrical Characteristics of Molecular-Beam-Deposited HfO$_{2}$ on n-InAs/InGaAs Metal–Oxide–Semiconductor Capacitors (2012)

The electrical characteristics of molecular-beam-deposited HfO2/n-InAs/InGaAs metal–oxide–semiconductor capacitors with different postdeposition annealing (PDA) temperatures (400–550 °C) are investigated. Results show that the sample with the PDA temperature of 500 °C exhibits the best capacitance–voltage (C–V) behavior with small frequency dispersion and small hysteresis. The X-ray photoelectron spectroscopy (XPS) spectra show the reduction of the amount of As-related oxides to below the XPS detection level when the PDA temperature is up to 500 °C. As the PDA temperature was increased to above 500 °C, As and In atoms seem to diffuse significantly into HfO2, resulting in the degradation of C–V behavior.
Different changes of bone mineral density and nutritional status after hospitalization between vascular dementia and Alzheimer's disease in elderly female patients (2007)

Background: Bone fractures strongly influence morbidity and mortality in elderly patients with dementia. The goal of this study was to examine whether difference in the type of dementia affects changes of bone mineral density (BMD) during hospitalization with rehabilitation programs. Methods: Ninety‐four Japanese elderly female patients were enrolled. BMD, Mini‐Mental State Examination (MMSE) scores, and levels of serum albumin, calcium‐related factors and urinary calcium excretion were measured. Results: Multivariable analyses indicated that serum albumin levels and MMSE scores were positively correlated with changes in BMD after 2 years hospitalization. Significant reduction of BMD levels after hospitalization were observed in patients with severe dementia (MMSE scores, &lt;10) or with severe malnutrition (serum albumin, &lt;2.0). We next classified our subjects into three groups according to the 4th edn of the Diagnostic and Statistical Manual criteria: non‐dementia (ND), Alzheimer's disease (AD) and vascular dementia (VaD). Although there were no significant differences in age and physical activities among the groups; the levels of BMD were maintained in AD as well as ND but not in VaD. Notably, calcium excretion levels were significantly decreased after hospitalization in AD as well as ND but not in VaD. Serum 25(OH)D levels were also restored in AD but not in VaD. In addition, the nutritional status significantly improved in AD but not in VaD. Conclusion: The levels of BMD were maintained and the nutritional status was improved in AD but not in VaD for 2 years hospitalization with rehabilitation programs. These results suggest that different programs including nutritional support may be necessary for maintaining BMD levels in VaD as compared with AD during hospitalization.
Passenger Car Noise Control Measures and Their Effects on Fuel Economy, Weight and Cost (1980)

&lt;div class="htmlview paragraph"&gt;Various passenger car practical noise control measures are presented and discussed. Emphasis is placed on the noise control tradeoffs with fuel economy and weight. Both diesel and gasoline powered automobiles were considered. The diesel was of the indirect injection type and a conventional spark ignition engine constituted the gasoline powered type. The baseline vehicle maintained throughout the analysis was a 2750 lb inertia weight passenger car (2400 lb, 1100 kg kerb weight). Major findings are summarised for five noise control measures considered to be most likely incorporated into future vehicles. They include: a) reduced engine speed by 10 percent, b) engine sizing and configuration, c) combustion process, d) engine structures, shielding and enclosures, and e) gas flow. Summaries for each noise control measure contain data on achievable noise reductions, and the corresponding change in fuel economy, vehicle weight and cost. Emission levels were referenced mainly to the 1979 Federal Light Duty Vehicle Emission Standards but some consideration was also given where relevant to the proposed 1981 Standards. The proposed particulate emission regulations were also considered. Noise measurements were referenced to a current high engine speed, full load drive-by test procedure (e.g. SAE J986b or similar European procedures, 70/157 EEC).&lt;/div&gt;
WAAS performance in the 2001 Alaska Flight Trials of the high speed Loran data channel (2003)

The wide area augmentation system (WAAS) enables the Global Positioning System (GPS) to provide the performance and integrity necessary for en route flight and many landing procedures. Currently, WAAS employs two geostationary satellites to provide coverage to the United States. However, operational WAAS will require a redundant broadcast of WAAS throughout the US. Additional geostationary satellites will be used to provide some redundancy. Loran can serve as a cost-effective additional broadcast channel for WAAS. While additional geostationary satellites are still necessary, Loran can further augment broadcast of the WAAS message particularly in terrain, urban canyons or high latitudes. Using Loran has some appealing features. First, Loran can be modified to attain the capacity to support the WAAS message. Second, it could also provide a reversionary positioning capability in case the GPS/WAAS signal is lost due to radio frequency interference (RFI). Loran can be particularly helpful in Alaska, where terrain combined with high latitudes could block the signal from the geostationary satellite that appears low in the Alaskan sky. This paper describes the flight and ground tests of the reception of WAAS from Loran and the geostationary satellite.
Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry (2011)

Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:
Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes (2002)

Protein kinase C delta (PKC delta) is tyrosine-phosphorylated and catalytically inactive in mouse keratinocytes transformed by a ras oncogene. In several other model systems, Src kinases are upstream regulators of PKC delta. To examine this relationship in epidermal carcinogenesis, v-ras transformed mouse keratinocytes were treated with a selective Src kinase inhibitor (PD 173958). PD 173958 decreased autophosphorylation of Src, Fyn, and Lyn kinases and prevented tyrosine phosphorylation of the Src kinase substrate p120. PD 173958 also prevented PKC delta tyrosine phosphorylation and activated PKC delta as detected by membrane translocation. Expression of keratinocyte differentiation markers increased in PD 173958-treated v-ras-keratinocytes, and fluid-filled domes emerged, indicative of tight junction formation. Antisense PKC delta or bryostatin 1 inhibited dome formation, while overexpression of PKC delta in the presence of PD 173958 enhanced the formation of domes. Plasmids encoding phenylalanine mutants of PKC delta tyrosine residues 64 and 565 induced domes in the absence of PD 173958, while phenylalanine mutants of tyrosine residues 52, 155, and 187 were inactive. Thus, Src kinase mediated post-translational modification of PKC delta on specific tyrosine residues in ras-transformed mouse keratinocytes inactivates PKC delta and contributes to alterations in the differentiated phenotype and tight junction formation associated with neoplasia.
Determination of Surface Exchange Coefficients of LSM, LSCF, YSZ, GDC Constituent Materials in Composite SOFC Cathodes (2011)

A novel approach to processing and modeling isothermal isotope exchange (IIE) data was developed to extract kinetic rate coefficients for the oxygen reduction reaction (ORR) on cathode materials used for solid oxide fuel cells (SOFC). IIE is capable of testing powders with particle sizes on the nano-scale, where the effective sample thickness (particle size) was shown to be below the characteristic thickness (L c ) for ionically conducting materials. This allows for accurate kinetic measurements in surface exchange controlled regimes, in contrast to secondary ion mass spectrometry depth profiling and electrical conductivity relaxation techniques where sample thicknesses are typically in the diffusion limited or mixed regimes. Surface exchange coefficients (k*) were extracted and L c values calculated from cathode (La 0.6 Sr 0.4 )(Co 0.2 Fe 0.8 )O 3–δ (LSCF) and (La 0.8 Sr 0.2 )MnO 3 (LSM), and electrolyte (Ce 0.9 Gd 0.1 )O 2–δ (GDC) and (Zr 0.8 Y 0.2 )O 2 (YSZ) materials. Additionally, diffusion coefficients (D*) were extracted for LSM. In a surface exchange controlled regime LSCF exhibits a low activation energy for k*, while for LSM k* was observed to increase with decreasing temperature consistent with a precursor-mediated mechanism in which there is a negative apparent activation energy for the dissociative chemisorption of O 2 . GDC was shown to exhibit a low activation energy for k*, lower than YSZ, which is attributed to higher concentration of electrons in GDC than YSZ.
Multi-die Integration Using Advanced Packaging Technologies (2020)

This paper presents a review of 2-D and 3-D multi-die integration technologies and focuses on on-package multi-die co-integration to create new types of system platforms. These dice may or may not be implemented in the same technology process. The paper first presents the challenges of process scaling and coexistence of logic, IO, and RF, and discusses new system/platform requirements from emerging applications. Following the motivation, a review of multi-die integration technologies with a focus on-package 2-D and 3-D multi-die integration and process enhancements for its support is provided. Finally, we present three new multi-die platforms which embody recent innovations in system platform integration to create new FPGA and CPU architectures which can be used to efficiently implement AI, HPC, and machine learning algorithms.
Modeling and Characterization of Negative Bias Temperature Instability in p-Channel MOSFETs (2007)

Negative bias temperature instability (NBTI) of nitrided gate oxides prepared with different nitridation process is characterized and the NBTI results can be well described by an analytical reaction-dispersive-diffusion model in the diffusion-limited regime. The activation energies are re- calculated by eliminating the non-Arrhenius part, and it confirms that both the interfacial nitrogen concentration and the nitrogen depth profile in the nitrided oxides play important roles in the nitrogen-enhanced NBTI. Furthermore, first-principles calculations are carried out to examine the effects of nitrogen as either the reaction site or the neighboring atoms at the interface. Lower reaction energies due to the incorporation of nitrogen suggest that nitrogen is a more effective hydrogen-originated hole trapping center than oxygen, and hence enhances NBTI. It is also found that hydrogen-originated hole trapping at vacancy defect has the strongest dependence on the nitrogen neighboring effect. Moreover, the role of nitrogen in NBTI is also investigated in terms of its influence on the electro-negativity and atomic charge distribution.