gebhart/patrepeval huggingface dataset:
Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity? (2016)

Different phenotypes have increasingly been used as tools for clinical characterization of frailty among older adults. Although there have been studies about the comparability and effectiveness of various simplifications and approximations of existing frailty phenotypes for risk prediction, there have been no studies in which investigators evaluated the stability of the clinical characterization achieved. In the present study, we used baseline (1992-1996) data from 786 community-dwelling women who were 70-79 years of age in the Women's Health and Aging Study I and II to compare physical frailty phenotypes (PFPs). Using the 5 criteria set forth by Fried, we created 15 PFPs that were positive for various combinations of 3 or 4 of those criteria and compared them with the PFP that included all 5 criteria in order to assess construct validity with regard to frailty syndrome characterization and predictive validity for adverse outcomes of aging. All PFPs exhibited high specificity and negative predictive values for identifying frailty syndrome. Three-item PFPs were insensitive but were the best performers for positive predictive value, with the highest positive predictive value of 0.86 seen in the PFP characterized by the combination of weakness, exhaustion, and weight loss. In comparison, the 5-criterion PFP achieved a sensitivity of 0.82 but a positive predictive value of only 0.53. With regard to predictive validity, it was not merely the number of criteria used to characterize the PFPs but rather the specific criteria combinations that predicted the risk of adverse outcomes. Our findings show that there clinically important contexts in which simplified PFPs cannot be used interchangeably.
Angiotensin II type-1 receptor antagonist, CS-866, reduces blood pressure without affecting glucose/insulin metabolism in cholesterol-fed rabbits. (2001)

CS-866 is an angiotensin II type-1 receptor antagonist, the effects of which on systolic blood pressure (BP) and glucose/insulin metabolism are investigated under hyperlipidaemic conditions produced by cholesterol feeding. Thirty-two female Japanese White rabbits (two months old) were assigned randomly into a CS-866-treated group (n = 17) fed a food admixture that contained 0.03% CS-866 and 0.2% cholesterol, or into a control group (n = 15) fed a food admixture containing 0.2% cholesterol only. Systolic BP was measured by an ear-cuff method. Glucose and insulin metabolism was characterised quantitatively from the results of an intravenous glucose tolerance test by a minimal model technique reported previously. After six months treatment, systolic BP in the CS-866-treated group was lower than in the control group (105 +/- 14 mmHg versus 115 +/- 18 mmHg; P <0.05), as assessed by analysis of variance and the Wilcoxon rank-sum test. No significant differences were seen in plasma aldosterone concentration, plasma renin activity, or angiotensin-converting enzyme activity between the groups. Administration of CS-866 for six months did not affect either glucose tolerance or insulin sensitivity. Other model parameters such as basal (steady-state) insulin and glucose concentration, first- and second-phase post-hepatic insulin delivery to glucose, and insulin clearance rate constant were unaffected. In conclusion, CS-866 treatment reduced systolic BP without affecting glucose/insulin metabolism under hyperlipidaemic conditions produced by cholesterol feeding.
The Effects of Conjugate Heat Transfer on the Thermal Field Above a Film Cooled Wall (2011)

Common gas turbine heat transfer analysis methods rely on the assumption that the driving temperature for heat transfer to a film cooled wall can be approximated by the adiabatic wall temperature. This assumption implies that the gas temperature above a film cooled adiabatic wall is representative of the overlying gas temperature on a film cooled conducting wall. This assumption has never been evaluated experimentally. In order for the adiabatic wall temperature as driving temperature for heat transfer assumption to be valid, the developing thermal boundary layer that exists above a conducting wall must not significantly affect the overriding gas temperature. In this paper, thermal fields above conducting and adiabatic walls of identical geometry and at the same experimental conditions were measured. These measurements allow for a direct comparison of the thermal fields above each wall in order to determine the validity of the adiabatic wall temperature as driving temperature for heat transfer assumption. In cases where the film cooling jet was detached, a very clear effect of the developing thermal boundary layer on the gas temperature above the wall was measured. In this case, the temperatures above the wall were clearly not well represented by the adiabatic wall temperature. For cases where the film cooling jet remained attached, differences in the thermal fields above the adiabatic and conducting wall were small, indicating a very thin thermal boundary layer existed beneath the coolant jet.
Non-Contact SWP Stability Estimation Using Laser-Ultrasonic Wave (2006)

Contact type detection, one of UT for the detection of defects in welding area, has several weak-points. Proximity type ultrasonic inspection using laser is being studied these days to make up for the weak points of contact type ultrasonic inspection. In this paper, automatic inspection system of the welding area of spiral welding pipe has been developed, of which mechanical characteristic is better than that of circular directional pipes, and executed the proximity ultrasonic inspections using laser. The usefulness of proximity ultrasonic inspection using laser will be verified in this paper through the analysis of the inspection results.
CMB-S4 (2019)

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey.
A Quantitative Analysis of Current Security Concerns and Solutions for Cloud Computing (2011)

The development of cloud computing services is speeding up the rate in which the organizations outsource their computational services or sell their idle computational resources. Even though migrating to the cloud remains a tempting trend from a financial perspective, there are several other aspects that must be taken into account by companies before they decide to do so. One of the most important aspect refers to security: while some cloud computing security issues are inherited from the solutions adopted to create such services, many new security questions that are particular to these solutions also arise, including those related to how the services are organized and which kind of service/data can be placed in the cloud. Aiming to give a better understanding of this complex scenario, in this article we identify and classify the main security concerns and solutions in cloud computing, and propose a taxonomy of security in cloud computing, giving an overview of the current status of security in this emerging technology.
An Automated Microfluidic System for Online Optimization in Chemical Synthesis (2010)

An automated, continuous flow system for the online, multivariable optimization of a chemical reaction is presented. Time and material required for an optimization trial are minimized by performing reactions in an integrated silicon microreactor and incorporating an HPLC for inline monitoring of the reaction performance. We use the system to optimize two different reactions to describe the potential impact of this system for reaction development. First, we demonstrate the broad operation capabilities by incorporating several feedback algorithms to optimize a weighted objective function involving the yield and the throughput of a Knoevenagel condensation reaction. After illustrating how system operations can be adapted for individual reactions, we perform a multiparameter optimization to maximize the yield of benzaldehyde in the oxidation pathway of benzyl alcohol to benzaldehyde to benzoic acid. A significant feature of the automated system is the ability to perform “black-box” optimization where no a priori information of the reaction parameters is required.
Current Detection Circuit in Multiple Parallel Connection Circuit of High-Power Semiconductor Modules (2021)

We are developing current-detection technology that directly measures the main current of a high-power semiconductor module using the wiring inductance of the module. In a previous study, we proposed a circuit that detects current by integrating the voltage generated in the wiring inductance between the sense emitter and emitter terminals of the IGBT (Insulated Gate Bipolar Transistor) module. In this study, we developed a total current detection scheme for parallel-connected modules.
Nonhuman Primate Models for Evaluation of AIDS Therapya (1990)

Infection of macaque monkeys with simian immunodeficiency virus (SIV) has been established as an excellent animal model system for studying the pathogenesis of an HIV-like virus and for evaluating newly developed antiretroviral drugs and vaccines. Based on their genetic, antigenic, and biologic properties, the simian immunodeficiency viruses are the closest known relatives of the human AIDS viruses, and experimental infection of macaque monkeys results in a disease that is remarkably similar to human AIDS. Infected macaques show diarrhea, weight loss, hematologic abnormalities including lymphopenia and thrombocytopenia, lymphadenopathy/lymphoid hyperplasia that progresses to lymphoid depletion, immunosuppression with marked reduction in CD4+ cells and in the CD4+/CD8+ cell ratio, and opportunistic infections. A majority of such macaques die from an AIDS-like disease within one to three years of infection. An acutely lethal variant of SIV has been identified that results in death in susceptible macaques within 7-12 days of infection. Preliminary prophylactic treatment trials with AZT in macaque monkeys exposed to the acutely lethal SIV variant indicate that some protection is provided when AZT treatment is initiated within 24 hours of virus exposure. Other studies with the more chronic SIV infection model, however, failed to show any prophylactic efficacy of CS-87, AZT, D4T, or FDT.
III-V/Si photonics by die-to-wafer bonding (2007)

Photonic integrated circuits offer the potential of realizing low-cost, compact optical functions. Silicon-on-insulator (SOI) is a promising material platform for this photonic integration, as one can rely on the massive electronics processing infrastructure to process the optical components. However, the integration of a Si laser is hampered by its indirect bandgap. Here, we present the integration of a direct bandgap III-V epitaxial layer on top of the SOI waveguide layer by means of a die-to-wafer bonding process in order to realize near-infrared laser emission on and coupled to SOI.
An Adaptive Positioning System for Smartphones in Zigbee Networks Using Channel Decomposition and Particle Swarm Optimization (2015)

ZigBee wireless sensor networks has the benefit of superior optimization in power consumption and extremely long battery life. In near future, the handheld devices are expected to incorporate support for wireless sensor networks technology, and these devices can become active elements in ZigBee-based applications such as automated buildings and advanced metering systems. Use of these applications is also promising for the expansion of location services into environments that do not have access to Global Navigation Satellite Systems (GNSS). Compared with the ToA (Time of Arrival) and TDoA (Time difference of Arrival) methods, RSSI (Received Signal Strength Indicator) has several advantages. It does not require additional hardware. Owing to the simplicity of RSSI, the most recent studies on localization using wireless sensor networks use RSSI-based algorithms. Previous works RSSI-based location estimation methods discussed by the literature depend on the impractical assumption that signal propagation characteristics are known and independent of both time variations and the environment. That assumption is invalid for the complex structures of indoor areas, which make the signal propagation characteristics for the same node differ significantly based on the orientation, even if the radiation pattern of the node is omnidirectional. Additionally, obtaining knowledge about signal propagation characteristics requires using manual data collection, which is impractical and time consuming. Furthermore, location estimation techniques must consider the large variations and high degree of uncertainty in RSSI observations. In this paper, we developed an adaptive localization system with low power and low cost, IEEE 802.15.4 ZigBee WSN. The under investigated system does not require manual pre-data collection and operates without performing exhaustive radio surveys. The first contribution in this paper is involving Kalman filtering for RSSI smoothing. Secondly, estimation of multi-link signal propagation characteristics; path loss exponent and Gaussian random variable in real-time by utilizing Particle Swarm Optimization (PSO). The results from the experiments are taken show that using the proposed multi-link channel decomposition estimation technique is more effective than using only one fixed value of PLE and X0. The overall localization accuracy is within two meters in root mean square.
Experience-Based Evolutionary Algorithms for Expensive Optimization (2023)

Optimization algorithms are very different from human optimizers. A human being would gain more experiences through problem-solving, which helps her/him in solving a new unseen problem. Yet an optimization algorithm never gains any experiences by solving more problems. In recent years, efforts have been made towards endowing optimization algorithms with some abilities of experience learning, which is regarded as experience-based optimization. In this paper, we argue that hard optimization problems could be tackled efficiently by making better use of experiences gained in related problems. We demonstrate our ideas in the context of expensive optimization, where we aim to find a near-optimal solution to an expensive optimization problem with as few fitness evaluations as possible. To achieve this, we propose an experience-based surrogate-assisted evolutionary algorithm (SAEA) framework to enhance the optimization efficiency of expensive problems, where experiences are gained across related expensive tasks via a novel meta-learning method. These experiences serve as the task-independent parameters of a deep kernel learning surrogate, then the solutions sampled from the target task are used to adapt task-specific parameters for the surrogate. With the help of experience learning, competitive regression-based surrogates can be initialized using only 1$d$ solutions from the target task ($d$ is the dimension of the decision space). Our experimental results on expensive multi-objective and constrained optimization problems demonstrate that experiences gained from related tasks are beneficial for the saving of evaluation budgets on the target problem.
Growth Mechanism and Controlled Synthesis of AB-Stacked Bilayer Graphene on Cu–Ni Alloy Foils (2012)

Strongly coupled bilayer graphene (i.e., AB stacked) grows particularly well on commercial "90-10" Cu-Ni alloy foil. However, the mechanism of growth of bilayer graphene on Cu-Ni alloy foils had not been discovered. Carbon isotope labeling (sequential dosing of (12)CH(4) and (13)CH(4)) and Raman spectroscopic mapping were used to study the growth process. It was learned that the mechanism of graphene growth on Cu-Ni alloy is by precipitation at the surface from carbon dissolved in the bulk of the alloy foil that diffuses to the surface. The growth parameters were varied to investigate their effect on graphene coverage and isotopic composition. It was found that higher temperature, longer exposure time, higher rate of bulk diffusion for (12)C vs(13)C, and slower cooling rate all produced higher graphene coverage on this type of Cu-Ni alloy foil. The isotopic composition of the graphene layer(s) could also be modified by adjusting the cooling rate. In addition, large-area, AB-stacked bilayer graphene transferrable onto Si/SiO(2) substrates was controllably synthesized.
In-situ sensing, process monitoring and machine control in Laser Powder Bed Fusion: A review (2021)

Process monitoring and sensing is widely used across many industries for quality assurance, and for increasing machine uptime and reliability. Though still in the emergent stages, process monitoring is beginning to see strong adoption in the additive manufacturing community through the use of process sensors recording a wide range of optical, acoustic and thermal signals. The ability to acquire these signals in a holistic manner, coupled with intelligence-based machine control has the potential to make additive manufacturing a robust and competitive alternative to conventional fabrication techniques. This paper presents an overview of the state-of the art of in-situ process monitoring in laser powder bed fusion processes and highlights some current limitations and areas for advancement. Also presented is an overview of real-time process control requirements, which when combined with the emergent process monitoring tools, will eventually allow for in-depth process control of the powder bed fusion process, which is essential for wide-scale industrial credibility and adoption of this technology.
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs (2017)

The DNA damage response (DDR) is a set of cellular events that follows the generation of DNA damage. Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNAs), have been shown to play a role in DDR signalling and DNA repair. Dysfunctional telomeres activate DDR in ageing, cancer and an increasing number of identified pathological conditions. Here we show that, in mammals, telomere dysfunction induces the transcription of telomeric DDRNAs (tDDRNAs) and their longer precursors from both DNA strands. DDR activation and maintenance at telomeres depend on the biogenesis and functions of tDDRNAs. Their functional inhibition by sequence-specific antisense oligonucleotides allows the unprecedented telomere-specific DDR inactivation in cultured cells and in vivo in mouse tissues. In summary, these results demonstrate that tDDRNAs are induced at dysfunctional telomeres and are necessary for DDR activation and they validate the viability of locus-specific DDR inhibition by targeting DDRNAs.
Near-zone expansions for the vector potential of the traveling-wave current loop antenna (2002)

This paper presents exact representations for the near-zone vector potential integrals corresponding to a thin circular loop antenna with a traveling-wave current distribution. These expansions are derived by employing an exact integration procedure for vector potentials of thin circular loops with arbitrary current distributions.
The C-Terminal Domain of the Archaeal Leucyl-tRNA Synthetase Prevents Misediting of Isoleucyl-tRNAIle (2007)

In the archaeal leucyl-tRNA synthetase (LeuRS), the C-terminal domain recognizes the long variable arm of tRNA(Leu) for aminoacylation, and the so-called editing domain deacylates incorrectly formed Ile-tRNA(Leu). We previously reported, for Pyrococcus horikoshii LeuRS, that a deletion mutant lacking the C-terminal domain (LeuRS_delta(811-967)) retains normal editing activity, but has severely reduced aminoacylation activity. In this study, we found that LeuRS_delta(811-967), but not the wild-type LeuRS, exhibited surprisingly robust deacylation activity against Ile-tRNA(Ile), correctly formed by isoleucyl-tRNA synthetase ("misediting"). Structural superposition of tRNA(Ile) onto the LeuRS x tRNA(Leu) complex indicated that Ile911, Lys912, and Glu913 of the LeuRS C-terminal domain clash with U20 of tRNA(Ile), which is bulged out as compared to the corresponding nucleotide of tRNA(Leu). The deletion of amino acid residues 911-913 of LeuRS enhanced the Ile-tRNA(Ile) deacylation activity, without affecting the Ile-tRNA(Leu) deacylation activity. These results demonstrate that the clashing between U20 of tRNA(Ile) and residues 911-913 of the LeuRS C-terminal domain is the structural mechanism that prevents misediting. In contrast, the deletion of the C-terminal domains of the isoleucyl- and valyl-tRNA synthetases impaired both the aminoacylation (Ile-tRNA(Ile) and Val-tRNA(Val) formation, respectively) and editing (Val-tRNA(Ile) and Thr-tRNA(Val) deacylation, respectively) activities, and did not cause misediting (Val-tRNA(Val) and Thr-tRNA(Thr) deacylation, respectively) activity. Thus, the requirement of the C-terminal domain for misediting prevention is unique to LeuRS, which does not recognize the anticodon of the cognate tRNA, unlike the common aminoacyl-tRNA synthetases.
Three-Dimensional Interfacing of Cells with Hierarchical Silicon Nano/Microstructures for Midinfrared Interrogation of In Situ Captured Proteins (2021)

Label-free optical detection of biomolecules is currently limited by a lack of specificity rather than sensitivity. To exploit the much more characteristic refractive index dispersion in the mid-infrared (IR) regime, we have engineered three-dimensional IR-resonant silicon micropillar arrays (Si-MPAs) for protein sensing. By exploiting the unique hierarchical nano- and microstructured design of these Si-MPAs attained by CMOS-compatible silicon-based microfabrication processes, we achieved an optimized interrogation of surface protein binding. Based on spatially resolved surface functionalization, we demonstrate controlled three-dimensional interfacing of mammalian cells with Si-MPAs. Spatially controlled surface functionalization for site-specific protein immobilization enabled efficient targeting of soluble and membrane proteins into sensing hotspots directly from cells cultured on Si-MPAs. Protein binding to Si-MPA hotspots at submonolayer level was unambiguously detected by conventional Fourier transform IR spectroscopy. The compatibility with cost-effective CMOS-based microfabrication techniques readily allows integration of this novel IR transducer into fully fledged bioanalytical microdevices for selective and sensitive protein sensing.
Phosphorelay of non-orthodox two component systems functions through a bi-molecular mechanism in vivo : the case of ArcB (2015)

Two-component systems play a central part in bacterial signal transduction. Phosphorelay mechanisms have been linked to more robust and ultra-sensitive signalling dynamics. The molecular machinery that facilitates such a signalling is, however, only understood in outline. In particular the functional relevance of the dimerization of a non-orthodox or hybrid histidine kinase along which the phosphorelay takes place has been a subject of debate. We use a combination of molecular and genetic approaches, coupled to mathematical and statistical modelling, to demonstrate that the different possible intra- and inter-molecular mechanisms of phosphotransfer are formally non-identifiable in Escherichia coli expressing the ArcB non-orthodox histidine kinase used in anoxic redox control. In order to resolve this issue we further analyse the mathematical model in order to identify discriminatory experiments, which are then performed to address cis- and trans-phosphorelay mechanisms. The results suggest that exclusive cis- and trans-mechanisms will not be operating, instead the functional phosphorelay is likely to build around a sequence of allosteric interactions among the domain pairs in the histidine kinase. This is the first detailed mechanistic analysis of the molecular processes involved in non-orthodox two-component signalling and our results suggest strongly that dimerization facilitates more discriminatory proof-reading of external signals, via these allosteric reactions, prior to them being further processed.