gebhart/patrepeval huggingface dataset:
Measurement of strange baryon–antibaryon interactions with femtoscopic correlations (2020)

Two-particle correlation functions were measured for pp, p , p , and pairs in Pb-Pb collisions at s NN = 2.76 TeV and s NN = 5.02 TeV recorded by the ALICE detector. From a simultaneous fit to all obtained correlation functions, real and imaginary components of the scattering lengths, as well as the effective ranges, were extracted for combined p and p pairs and, for the first time, for pairs. Effective averaged scattering parameters for heavier baryon-antibaryon pairs, not measured directly, are also provided. The results reveal similarly strong interaction between measured baryon-antibaryon pairs, suggesting that they all annihilate in the same manner at the same pair relative momentum k * . Moreover, the reported significant non-zero imaginary part and negative real part of the scattering length provide motivation for future baryon-antibaryon bound state searches.
Metal-embedded fiber-optic Fabry–Perot sensors (1991)

The sensing of temperature and of ultrasonic pressure with fiber-optic Fabry-Perot interferometers embedded in aluminum is demonstrated. The metal parts are cast in air by using graphite molds. Breakage of the fibers at the air-metal interface during the casting process is avoided through the use of stainless-steel stress-relief tubes. The optical phase in an embedded interferometer is found to be 2.9 times more sensitive to temperature change than for the same interferometer in air, in good agreement with model calculations. An embedded interferometer has also been used to detect ultrasonic waves over the frequency range of 0.1-8 MHz.
Compositional and immunobiological analyses of extracellular vesicles released byCandida albicans (2014)

The release of extracellular vesicles (EV) by fungal organisms is considered an alternative transport mechanism to trans-cell wall passage of macromolecules. Previous studies have revealed the presence of EV in culture supernatants from fungal pathogens, such as Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis, Sporothrix schenckii, Malassezia sympodialis and Candida albicans. Here we investigated the size, composition, kinetics of internalization by bone marrow-derived murine macrophages (MO) and dendritic cells (DC), and the immunomodulatory activity of C. albicans EV. We also evaluated the impact of EV on fungal virulence using the Galleria mellonella larvae model. By transmission electron microscopy and dynamic light scattering, we identified two populations ranging from 50 to 100 nm and 350 to 850 nm. Two predominant seroreactive proteins (27 kDa and 37 kDa) and a group of polydispersed mannoproteins were observed in EV by immunoblotting analysis. Proteomic analysis of C. albicans EV revealed proteins related to pathogenesis, cell organization, carbohydrate and lipid metabolism, response to stress, and several other functions. The major lipids detected by thin-layer chromatography were ergosterol, lanosterol and glucosylceramide. Short exposure of MO to EV resulted in internalization of these vesicles and production of nitric oxide, interleukin (IL)-12, transforming growth factor-beta (TGF-β) and IL-10. Similarly, EV-treated DC produced IL-12p40, IL-10 and tumour necrosis factor-alpha. In addition, EV treatment induced the up-regulation of CD86 and major histocompatibility complex class-II (MHC-II). Inoculation of G. mellonella larvae with EV followed by challenge with C. albicans reduced the number of recovered viable yeasts in comparison with infected larvae control. Taken together, our results demonstrate that C. albicans EV were immunologically active and could potentially interfere with the host responses in the setting of invasive candidiasis.
Incomplete mixing in porous media: Todd-Longstaff upscaling approach versus a dynamic local grid refinement method (2018)

Field-scale simulation of flow in porous media in presence of incomplete mixing demands for high-resolution computational grids, much beyond the scope of state-of-the-art simulators. Hence, the upscaling-based Todd and Longstaff (TL) approach is typically used, where coarse grid cells are employed with effective mixing fluid properties and parameters found by matching results obtained with fully resolved reference simulations. Dynamic local grid refinement (DLGR) techniques, on the other hand, only employ fine-scale grid resolution where the fully mixed assumption is not valid. The rest of the domain is then solved at coarser resolutions, where the fully mixed assumption is valid. Here, we assess the accuracy and the robustness of DLGR- and TL-based simulations of miscible displacements in homogeneous and heterogeneous porous media. Due to the intrinsic uncertainty within the unstable displacement nature of the studied incomplete mixing processes, the performance of the methods is also investigated based on a range of acceptable solutions rather than relying only on a single reference one. Systematic numerical results illustrate that the DLGR method is much more robust and accurate than the upscaling-based TL approach, and employs only a small fraction of fine-scale reference grids. Especially, the TL upscaling results (though history matched with computationally expensive fine-scale results) are very sensitive to the change of the simulation parameters. Based on this study, we propose a dynamic multilevel simulation strategy for efficient and reliable large-scale simulation of the complex incomplete mixing processes.
Compact dual-band frequency agile antenna designed for carrier aggregation LTE small cell (2015)

This paper deals with a highly integrated frequency agile antenna design optimized for a specific LTE small cell base station using Carrier Aggregation (CA) technique for network capacity improvement. A novel compact dual access LTE antenna system is proposed combining a LTE band 7 antenna and a LTE band 20 antenna. This antenna system is composed of a regular microstrip patch antenna for LTE band 7 and a more complex dual band frequency agile folded microstrip patch antenna for LTE band 20. Available CA modes have driven the antenna design towards the frequency agile volume optimized antenna solution presented in this work. It only covers the required instantaneous bandwidth while standard static antennas would require a wider bandwidth and therefore a larger volume to be compatible with all CA modes.
Reliability assessment of multi-sensor perception system in automated driving functions (2021)

Precise environment perception, which consists of multi-sensor systems, ensures the safety of the automated driving functions (ADFs). With the rapid evolution of sensor technologies, sensor data collection errors occur rarely. Nevertheless, accurate interpretation of the sensor data context, such as 3D multi-object tracking, is still full of challenges. Safety of the Intended Functionality (SOTIF) takes concern of the vulnerability of perception systems. The research of quantitative SOTIF analysis is still ongoing. In this paper, we propose a multi-sensor system model to observe both false negative and false positive errors in different field-of-views. Besides, we also extend a proven Markov-based approach, which takes dependencies between successive sensor errors and correlation between two dependent sensors into account, to model three correlated sensors sharing the same region of interest. In the end, we present a numerical example to illustrate the quantitative reliability analysis of a multi-sensor perception system according to SOTIF.
Arene Coupling Reactions (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: ROS Receptor Tyrosine Kinase: A New Potential Target for Anticancer Drugs (2011)

Abstract Review: 150 refs.
Anti-CD19 chimeric antigen receptor T cells preceded by low-dose chemotherapy to induce remissions of advanced lymphoma. (2016)

LBA3010 Background: T cells genetically-modified to express chimeric antigen receptors (CARs) targeting CD19 have potent activity against a variety of B-cell malignancies. Chemotherapy is administered prior to CAR T cells because depletion of recipient leukocytes enhances the anti-malignancy efficacy of adoptively-transferred T cells; an increase in serum interleukin (IL)-15 is one mechanism for this enhancement. Previously, we (Kochenderfer et al. Journal of Clinical Oncology, 2015) and others have reported patients treated with high-dose chemotherapy prior to anti-CD19 CAR T-cell infusions. This report describes treatment of 22 patients with low-dose conditioning chemotherapy followed by infusion of anti-CD19 CAR T-cells. Methods: Eighteen of 22 treated patients received 300 mg/m 2 of cyclophosphamide (cy) daily for 3 days; 4 patients received 500 mg/m 2 of cy on the same schedule. All patients received fludarabine 30 mg/m 2 daily for 3 days on the same days as cy. Patients received a single dose of CAR T cells 2 days after completion of chemotherapy. Blood CAR T cells and serum cytokines were analyzed in all patients. Results: Nineteen patients with various subtypes of diffuse large B-cell lymphoma (DLBCL) had the following responses: 8 CR, 5 PR, 2 SD, and 4 PD. One patient with mantle cell lymphoma obtained a CR. Two patients with follicular lymphoma both obtained CRs. Durations of response currently range from 1 to 20 months; 10 remissions are ongoing. All but 4 patients had either chemotherapy-refractory lymphoma or lymphoma that had relapsed after autologous stem cell transplant. The most prominent toxicities were various neurological toxicities. Other toxicities included fever and hypotension. The median peak blood CAR+ cell level was 47/μL (range 4-1217/μL). Patients obtaining CRs or PRs had higher peak blood CAR+ cell levels than patients experiencing SD or PD. The mean serum IL-15 level was 4 pg/mL before the conditioning chemotherapy and 32 pg/mL after chemotherapy (P &lt; 0.0001). Conclusions: Anti-CD19 CAR T cells can induce remissions of advanced B-cell lymphoma when administered after low-dose chemotherapy. In the near future, CAR T cells will likely be a standard therapy for lymphoma. Clinical trial information: NCT00924326.
Directly probing the mechanical properties of the spindle and its matrix (2010)

Several recent models for spindle length regulation propose an elastic pole to pole spindle matrix that is sufficiently strong to bear or antagonize forces generated by microtubules and microtubule motors. We tested this hypothesis using microneedles to skewer metaphase spindles in Xenopus laevis egg extracts. Microneedle tips inserted into a spindle just outside the metaphase plate resulted in spindle movement along the interpolar axis at a velocity slightly slower than microtubule poleward flux, bringing the nearest pole toward the needle. Spindle velocity decreased near the pole, which often split apart slowly, eventually letting the spindle move completely off the needle. When two needles were inserted on either side of the metaphase plate and rapidly moved apart, there was minimal spindle deformation until they reached the poles. In contrast, needle separation in the equatorial direction rapidly increased spindle width as constant length spindle fibers pulled the poles together. These observations indicate that an isotropic spindle matrix does not make a significant mechanical contribution to metaphase spindle length determination.
Faster sensitivity and non-antimonite permanent photoresist for MEMS (2006)

Micro Electro Mechanical Systems (MEMS) is a three-dimensional micro-fabrication technology based on photolithography. The fields of application are extensive and wide-ranging. Among the applications, those that have already acquired a large market include acceleration sensors for airbags of automobiles, pressure sensors for engine control, inkjet printer heads and thin film magnetic heads. The market is expected to further expand in the optic and biology-related fields in the future. In the MEMS field, the packaging accounts for the cost, and it is difficult to standardize due to the low production volume of highly specific technology application. A typical application in the MEMS process would be to conduct plating and etching (Deep RIE) through an intermediate layer of photoresist patterns, but there are cases where the photoresist itself is left therein as a permanent film. A photoresist composed of epoxy resin as the main component can form the permanent film through a catalyst of the optical cationic polymerizating initiator. In general, the optical cationic polymerizating initiator is of onium salt with antimonite as the anion group due to the nature of the hardening rate or the exposure energy. This paper presents the development status of a high sensitivity permanent photoresist made of epoxy resin as the main component with non-antimonite optical cationic polymerizating initiator with concerns to the impact to the environment and material for packaging.
Dynamic Analysis and Control Approach for a High-Gain Step-Up Converter for Electrified Transportation (2017)

Electric power take-off system has gained significant popularity in automobiles and aircraft. The system requires a high-gain step-up converter to boost the voltage of the low-voltage batteries. A novel topology has been proposed for these applications. The output voltage requires good regulation during load changes. This paper presents the dynamic modeling of the converter using generalized averaging method. A small-signal model is developed by linearizing around the operating points. The analysis of system stability indicates that the system is stable at all operating points. The sensitivity of parameters such as leakage inductance and load resistance has been studied to analyze the effect of these parameters in the context of system behavior and the controller design. A dedicated controller has been designed, which includes a feedback controller to regulate the output voltage and a lead compensator to solve the potential instability issue brought by the right-half-plane zeros. It also includes a feedforward controller in its inner loop to eliminate the effect of the disturbance in the input voltage. Simulation and experimental results have been used to validate the system model and the proposed controller.
Effect of nano graphene oxide (nGO) incorporation on the lipophilicity of hydrophobic drugs (2023)

Lipophilicity is a measure of partitioning of an active pharmaceutical ingredient (API) in a lipophilic phase and has been shown to affect gastrointestinal absorption. If a hydrophobic API is completely water insoluble; it does not dissolve in the aqueous phase and is not available for absorption in the gastrointestinal (GI) lipid layer. Therefore, an optimum lipophilicity is important for enhanced bioavailability. It is typically measured as logP or log (Octanol-Water partition coefficient). While water soluble drugs tend to have negative values, high logP can be a problem with insoluble drugs. There are no strict guidelines on logP for hydrophobic drugs, but typically a logP between 0 and 2 is desirable. In this paper, we represent the lowering of logP of hydrophobic API via the successful incorporation of 0.5–2.0% of nanographene oxide (nGO). Four hydrophobic drugs namely Griseofulvin (GF), Dexamethasone (DXM), Apixaban (APX) and Megestrol Acetate (MA) were tested at physiological/intestine pH of 6.0, 7.0, and 8.0 to estimate partitioning behavior. The increased nGO incorporation led to the substantial decrease in logP of all the nGO formulated drugs at all pH as compared to pure drugs. In the cases of GF, APX and MA, the logP decreased from over 2.0 to somewhere between 1.0 and 2.0, and for DXM these decreased to negative values thus making it behave like a water soluble API. The maximum decrease in logP for DXM, GF, APX and MA were 157, 54, 61 and 64% respectively. In summary, the nGO incorporation is an effective means to lower logP and may significantly lead to improved biological absorption and therapeutic efficacy. We believe that current study is very promising for improving efficacy and potentially lowering drug dosage.
Pneumatosis intestinalis in adults with AIDS: clinical significance and imaging findings. (1995)

Pneumatosis intestinalis is a late-stage phenomenon in adult patients with AIDS that characteristically involves the cecum or right colon. Pneumatosis in patients with AIDS may be an indolent abnormality and does not necessarily constitute a surgical emergency or a sign of impending bowel necrosis.
Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells (2023)

Venous malformations (VMs) consist of hugely enlarged and dysmorphic veins. These lesions cause significant disfigurement, pain, and complications such as bleeding and coagulopathy. Pharmacotherapy for the treatment of VMs has limited efficacy and potentially limiting toxicity. Current treatment for patients with VMs entails life-long pharmacotherapy or surgical procedures. Here we explored whether intravenously administered agents can be used to destroy VMs by photothermal therapy (PTT), using gold nanoshells (AuNSs) that generated heat following irradiation with near-infrared (NIR) light. In a murine model of VMs, intravenous AuNSs accumulated within the VMs. Irradiation of the VMs induced marked regression and even elimination. Nanoparticle-based photothermal therapy can provide effective therapy for VMs, which are otherwise relatively refractory to treatment.
Nonlinear optical analysis of a series of triblock copolymers containing model polyenes: the dependence of hyperpolarizability on conjugation length (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonlinear optical analysis of a series of triblock copolymers containing model polyenes: the dependence of hyperpolarizability on conjugation lengthG. S. W. Craig, R. E. Cohen, R. R. Schrock, R. J. Silbey, G. Puccetti, I. Ledoux, and J. ZyssCite this: J. Am. Chem. Soc. 1993, 115, 3, 860–867Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ja00056a006https://doi.org/10.1021/ja00056a006research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactive Multimedia Presentation for Applied Computer Tomography: Impact. (1994)

Abstract : An interactive multimedia presentation has been developed for viewing on a Macintosh workstation that summarizes the results of the 'Advanced Development of X-ray Computed Tomography Applications' demonstration (CTAD) program. The Interactive Multimedia Presentation for Applied Computed Tomography (IMPACT) package includes the following areas: (1) Conclusions and Recommendations, (2) X-Ray Computed Tomography, (3) CT Application Stories, (4) Interactive Imaging Program and (5) For More Information. The 'Advanced Development of X-ray Computed Tomography Applications' demonstration (CTAD) program, sponsored by Wright Laboratory, generated significant amounts of data and conclusions on the application of X-ray computed tomography (CT) to aircraft structures, materials and components. Over 18 formal technical reports have been written for WL publication. The approach for summarizing the data has been to create a presentation package for use on a Macintosh computer containing the major conclusions of the CTAD program with a number of specific examples. The package can be used by an individual to review information or can be used by a presenter to an audience with an LCD screen and overhead projector. The interactive multimedia allows the users to move through the material at their pace, entering deeper levels of detail as desired. The presentation contains the summary conclusions of the CTAD program, background material on basic X-Ray CT, examples of the applications of computed tomography that were demonstrated in the CTAD program, an image processing program for demonstrating CT image analysis, and references for more information. The CD presentation package is available from Wright Laboratory. (MM)
Anisotropic metamaterial blueprints for cladding control of waveguide modes (2010)

We explore the duality between metric and material properties in the Maxwell&#x2019;s equations to design metamaterial blueprints for cladding control of waveguide modes. We illustrate designs for circular and rectangular waveguides. In contrast to standard material loading of waveguides, the proposed cladding does not produce hybrid modes. The cutoff frequencies of the propagating modes can be controlled by the material parameters in a simple fashion.
Comparison of three models for permeation of CO2/CH4 mixtures in poly(phenylene oxide) (1989)

Abstract Two models for the permeability of pure gases have been extended to include binary gas mixtures. The first is an extension of a pure gas permeability model, proposed by Petropoulos, which is based on gradients of chemical potential. This model predicts the permeability of components in a gas mixture solely on the basis of competition for sorption sites within the polymer matrix. The second mixed gas model follows an earlier analysis by Barrer for pure gases which includes the effects of saturation of Langmuir sites on the diffusion as well as the sorption processes responsible for permeation. This generalized “competitive sorption/diffusion” model includes the effect of each gas component on the sorption and diffusion of the other component in the mixture. The flux equations from these two models have been solved numerically to predict the permeability of gas mixtures on the basis of pure gas sorption and transport parameters. Both the mixed gas Petropoulos and competitive sorption/diffusion model predictions are compared with predictions from the earlier simple competitive sorption model based on gradients of concentration. An analysis of all three models is presented for the case of CO 2 /CH 4 permeability in poly(phenylene oxide) (PPO). As expected, the competitive sorption/diffusion model predicts lower permeability than either of the models which consider only competitive sorption effects. The permeability depression of both CO 2 and CH 4 predicted by the competitive sorption/diffusion model is roughly twice that predicted by the competitive sorption model, whereas the mixed gas Petropoulos model predictions for both gases lie between the other two model predictions. For the PPO/CO 2 /CH 4 system, the methane permeability data lie above the predictions of all three models, whereas CO 2 data lie below the predictions of all models. Consequently, the competitive sorption/diffusion model gives the most accurate prediction for CO 2 , while the simple competitive sorption model is best for methane. The effects of mixed gas sorption, fugacity, and CO 2 ‐induced dilation were considered and do not explain the inaccuracies of any of the models. The relatively small errors in mixed gas permeability predictions using either of the three models are likely to be related to “transport plasticization” of PPO owing to high levels of CO 2 sorption and its effect on polymer segmental motions and gas diffusivity.