gebhart/patrepeval huggingface dataset:
Wavelet Galerkin methods for elastic multibody systems with unilateral contact constraints (2004)

In this thesis we investigate the applicability of wavelets to simulate the time behavior of elastic multibody systems (MBS) with contact constraints. For this end, a wavelet element method (WEM) was implemented, exploiting the special structure of the coupled ODE/PDE equations that govern elastic MBS. Special care has to be taken to adapt the method to the particular geometry of the elastic bodies. The use of WEM as an alternative to finite elements is discussed, focusing on the particular aspects of system reduction and adaptive handling of contact problems, where we see its strengths. This WEM/FEM space semidiscretisation is integrated in time using modified versions of DASSL and ODASSL. A simplified model of a rolling bearing is taken as test case of a typical industrial application.
ChemInform Abstract: A NEW GENERAL REGIOCONTROLLED SYNTHESIS OF ANTHRACYCLINONES USING CYCLOADDITION OF HOMOPHTHALIC ANHYDRIDES TO 2‐CHLORO‐6‐OXO‐5,6,7,8‐TETRAHYDRO‐1,4‐NAPHTHOQUINONE 1,2‐ETHANEDIYL ACETAL (1983)

Abstract Aus den beiden isomeren Dichlorbenzochinonen (Ia) und (Ib) entstehen mit dem 2‐Trimethylsiloxybutadien (II) die Addukte (III), die in die Ketale (IV) umgewandelt werden.
From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay (2010)

Abstract Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life-science applications, we developed a streamlined, plate-based version of the assay. The plate-based version of the assay is robust, sensitive (sub-picomolar), rapid, can be highly multiplexed (upwards of 60 analytes), and fully automated. We demonstrate that quantification by microarray-based hybridization, Luminex bead-based methods, and qPCR are each compatible with our platform, further expanding the breadth of proteomic applications for a wide user community.
Substrate-Mediated Oxidation of Carbon Residues by TiO2{110}-Supported Model Catalysts:  Metal-, Precursor-, and Treatment-Dependent Labilization of Framework Oxygen (2000)

Thermal and chemical treatment of metallo-organic chemical vapor deposition (MOCVD)-prepared Rh and Pd model catalysts, supported on TiO2{110}, lead to the formation of carbon residues that are oxidized to CO at elevated temperatures. These processes are metal, metal precursor, and surface- treatment dependent. In the absence of surface Cl, Rh precursors exhibit surface carbon oxidation, at T > 775 K. In the case of Pd this is not seen until T > 825 K and some carbon is always found to remain. Room-temperature reduction of the model catalysts using hydrogen progressively lowers the temperature of carbon oxidation. However, reduction of a Cl-containing system dramatically promotes CO oxidation/Ar expulsion in a manner that is kinetically distinct from that observed in the absence of Cl. These observations are discussed in terms of the mobility of surface oxygen species on TiO2{110}, metal−support interactions, and the effect of Cl incorporation into the TiO2 substrate.
Heurs et malheurs du séquençage à haut débit en virologie. (2014)

Les techniques de sequencage a haut debit (Next Generation Sequencing, NGS) ont permis a la fois le developpement de nouveaux concepts et de nouveaux outils dans de nombreuses disciplines, dont la virologie. Sous ce terme, on englobe des approches differentes, qui ont pour consequence d’elargir considerablement la liste des virus identifiables. Prealablement a l’essor du NGS, differentes strategies avaient ete developpees dans cet objectif, dont les puces a ADN, mais celles-ci [...]
Pre-treatment circulating tumor DNA as a biomarker for disease burden in diffuse large B cell lymphoma (DLBCL). (2015)

8539 Background: Patients with DLBCL reveal striking heterogeneity in clinical outcomes. Plasma cell-free DNA (cfDNA) levels have been shown to be adversely prognostic. Both circulating tumor DNA (ctDNA) as a minor fraction of cfDNA and circulating tumor cells (CTCs) can be used for DLBCL monitoring with ctDNA reported to be superior (Kurtz et al 2014 ASCO). However, the relationship between ctDNA and CTC levels with DLBCL clinical indices remains poorly defined. Methods: We profiled 43 DLBCL patients treated with R-CHOP based therapy and quantified their pre-treatment cfDNA, ctDNA and CTC levels. Pre-treatment ctDNA levels were determined by high-throughput sequencing of tumor specific immunoglobulin genes (Ig-HTS) of plasma cfDNA, and CTCs were enumerated by Ig-HTS of blood leukocytes. Metabolic tumor volume (MTV) was measured from pre-treatment 18FDG PET/CT scans using MetaVol. Parametric vs. non-parametric tests supported identical conclusions. Results: Blood cfDNA levels varied widely (2.8-1,713.5 ng/mL, median: 12.6), as did ctDNA levels (0-129,928 molecules/mL, median 87.5) and CTCs (0-454,400 CTCs/million cells, median 6.6). Total cfDNA levels and the amount of ctDNA were strongly associated (r = 0.73, P < 0.0001). Both cfDNA and ctDNA levels were significantly correlated with LDH (r = 0.79 and 0.74, P < 0.0001) and MTV (r = 0.62 and 0.53, P < 0.0001 and P = 0.002). CtDNA was detectable in 14 of 19 patients (74%) with normal LDH levels. Higher cfDNA and ctDNA levels were associated with adverse prognostic parameters including advanced stage (P < 0.0001 and P = 0.04), IPI 3-5 (P < 0.0001 and P = 0.04), marrow involvement (P = 0.04 and P = 0.009) and presence of B-symptoms (P = 0.0003 and P = 0.0001). CTCs levels were not associated with any of these prognostic parameters, despite showing a correlation with LDH (r = 0.43, P = 0.02). Conclusions: Our study demonstrates that, in contrast to CTCs, ctDNA levels better capture disease burden in DLBCL, including tumor volume and metabolic properties. The prognostic value of cfDNA levels appears directly related to ctDNA levels, and not to CTCs. Therefore, ctDNA is a specific biomarker of tumor burden in DLBCL and, compared to cfDNA, less prone to physiological perturbations.
Ammonia Gas Sensor Using Thick Film of Au-Loaded Tungsten Trioxide (1996)

Thick films of Au-loaded WO3 mixed with glass frit were prepared on an alumina substrate by the printing method, and influences of film thickness, Au-loading and operating temperature on the NH3 sensing characteristics were investigated. With an increase in film thickness and Au-loading, the maximum sensitivity (Km) increased, while the temperature for maximum sensitivity (Tm) decreased. An optimum film was revealed to be the 4.0mass% Au-loaded one of a 250μm-thickness for the optimum operating temperature of 450°C. The sensor proved excellent NH3 sensing characteristics in gas sensitivity, response transient, resistance to humidity and long-term stability when subjected to heat cleaning once a day during its operation.
Normative Brain Size Variation and the Remodeling of Brain Shape in Humans (2017)

Abstract Evolutionary and developmental increases in primate brain size have been accompanied by systematic shifts in the proportionality of different primate brain systems. However, it remains unknown if and how brain patterning varies across the more than 2-fold inter-individual variation in brain size that occurs amongst typically-developing humans. Using in vivo neuroimaging data from 2 independent cohorts totaling nearly 3000 individuals, we find that larger-brained humans show preferential areal expansion within specific fronto-parietal cortical networks (default mode, dorsal attentional) and related subcortical regions, at the expense of primary sensory/motor systems. This targeted areal expansion recapitulates cortical remodeling across evolution, manifests by early childhood and is linked to molecular signatures of heightened metabolic cost. Our results define a new organizing principle in human brain patterning which governs the highly-coordinated remodeling of human brain shape as a function of naturally-occurring variations in brain size. One Sentence Summary A hodologically and metabolically expensive brain network is preferentially expanded in larger-brained humans.
Session details: Can EDA combat the rise of electronic counterfeiting? (2012)

No abstract available.
Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging (2023)

A simple method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
ChemInform Abstract: EFFECT OF PARA SUBSTITUENT ON RATES OF PHENYL RING ROTATION IN GALLIUM COMPLEXES OF PARA‐SUBSTITUTED TETRAPHENYLPORPHYRINS (1978)

Abstract Mittels temperaturabhängiger 1 H‐NMR‐ Spektren werden die Geschwindigkeiten der Phenylringrotation in den Chloro‐Galliumkomplexen (I) untersucht.
Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP (2010)

We propose that, DCPIP may serve as a potent tool to prevent or disrupt the processes of cell proliferation, tissue angiogenesis and inflammation by directly or indirectly targeting expression of specific cellular factors. We also propose that the activities of DCPIP may be long-lasting and/or enhanced if it is delivered enclosed in specific nanoparticles.
ChemInform Abstract: Multistep Synthesis of Amides from Alcohols and Amines in Continuous Flow Microreactor Systems Using Oxygen and Urea Hydrogen Peroxide as Oxidants. (2013)

Abstract The oxidation of alcohols (I) in a packed‐bed microreactor followed by oxidative amidation of resulting aldehydes with amines (II) in a spiral‐channel microreactor leads to a wide range of amides (III).
Supplementary Figure 1 from MS4A12 Is a Colon-Selective Store-Operated Calcium Channel Promoting Malignant Cell Processes (2023)

Supplementary Figure 1 from MS4A12 Is a Colon-Selective Store-Operated Calcium Channel Promoting Malignant Cell Processes
Multipacket Reception in Wireless Local Area Networks (2006)

The conventional MAC (Medium Access Control) protocols assume that only one packet can be received at a given time. However, with the advent of sophisticated signal processing and antenna array techniques, it is possible to achieve multipacket reception (MPR) in the physical layer (PHY). In this paper, we propose a PHY methodology and the corresponding MAC protocol for MPR in wireless local area networks (WLANs). The proposed MAC protocol closely follows the 802.11 DCF (Distributed Coordination Function) scheme and enables MPR in a distributed manner. For the proposed MPR system, a closed-form expression of the average throughput is derived. Based on the expression, an optimal transmission probability that maximizes the throughput can be attained. In addition, two enhancement schemes are presented to further improve the performance of the MPR protocol. Numerical results show that the proposed MPR system can considerably increase the spectrum efficiency compared to the WLANs with conventional collision models.
Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening (2017)

Few tools are available for noninvasive imaging of synapses in the living mammalian brain. Current paradigms require the use of genetically modified mice or viral delivery of genetic material to the brain. To develop an alternative chemical approach, utilizing the recognition of synaptic components by organic small molecules, we designed an imaging-based, high-content screen in cultured cortical neurons to identify molecules based on their colocalization with fluorescently tagged synaptic proteins. We used this approach to screen a library of ∼7000 novel fluorescent dyes, and identified a series of compounds in the xanthone family that exhibited consistent synaptic labeling. Follow-up studies with one of these compounds, CX-G3, demonstrated its ability to label acidic organelles and in particular synaptic vesicles at glutamatergic synapses in cultured neurons and murine brain tissue, indicating the potential of this screening approach to identify promising lead compounds for use as synaptic markers, sensors, and targeting devices.
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment (2022)

Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (CAR) T cells and tumor cells, for the limited availability of amino acids within the environment. We demonstrate that T cells can be re-engineered to express SLC7A5 or SLC7A11 transmembrane amino acid transporters alongside CARs. Transporter modifications increase CAR T-cell proliferation under low tryptophan or cystine conditions with no loss of CAR cytotoxicity or increased exhaustion. Transcriptomic and phenotypic analysis reveals that downstream, SLC7A5/SLC7A11-modified CAR T cells upregulate intracellular arginase expression and activity. In turn, we engineer and phenotype a further generation of CAR T cells that express functional arginase 1/arginase 2 enzymes and have enhanced CAR T-cell proliferation and antitumor activity. Thus, CAR T cells can be adapted to the amino acid metabolic microenvironment of cancer, a hitherto recognized but unaddressed barrier for successful CAR T-cell therapy.
Sleep Surgery in the Elderly: Lessons from the National Surgical Quality Improvement Program (2017)

Objective Assess the frequency and nature of postoperative complications following sleep surgery. Examine these issues specifically in elderly patients to provide guidance for their perioperative care. Study Design Retrospective cohort study. Setting American College of Surgeons National Surgical Quality Improvement Program. Methods We identified patients with obstructive sleep apnea undergoing sleep surgery procedures from 2006 to 2013 in the American College of Surgeons National Surgical Quality Improvement Program, a multi-institutional outcomes program designed to improve surgical quality. We analyzed patients by comparing age groups: <65 and ≥65 years. Summary data were analyzed, and multivariate regression was used to adjust for patient characteristics, comorbidities, and surgical procedure. Results We identified 2230 patients who had sleep surgery, which included 2123 patients <65 years old and 107 patients ≥65 years old. Elderly patients were significantly more likely to have hypertension requiring medication ( P < .001) and higher American Society of Anesthesiologists scores ( P < .001). There were no significant differences in the rates of nasal ( P = .87), palate ( P = .59), tongue base ( P = .73), and multilevel ( P = .95) surgery being performed on both groups of patients. Elderly patients had higher rates of wound complications and urinary tract infections as compared with younger patients. On multivariate analysis, age ≥65 was significantly associated with complications from sleep surgery (odds ratio, 2.35; 95% CI, 1.04-5.35). Conclusion Elderly patients undergoing sleep surgery have increased postoperative complication risk as compared with younger patients treated similarly. This information can help direct quality improvement efforts in the care of older patients.
0.5-V Low-$V _{\rm T}$ CMOS Preamplifier for Low-Power and High-Speed Gigabit-DRAM Arrays (2010)

A novel low-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> CMOS preamplifier was developed for low-power and high-speed gigabit DRAM arrays. The sensing time of a sense amplifier (SA) with the proposed preamplifier and its activation schemes at a data-line voltage of 0.5 V was 6 ns, which is 62% shorter than that of an SA using a conventional preamplifier. By activating the proposed preamplifier temporarily during the write cycle, the writing time was 16.3 ns, which is 72% shorter than the case without activation of the proposed preamplifier, and this time is short enough to apply a DRAM array using the proposed preamplifier to 1.6-Gbit/s/pin DDR3 SDRAM. The operating current of the memory array and its peripheral circuit including the proposed preamplifier was reduced by 12% by reducing the data-line voltage from 0.8 to 0.5 V.
Retinal Vascular Caliber and Extracranial Carotid Disease in Patients With Acute Ischemic Stroke (2009)

In patients with acute stroke, retinal venular widening was strongly associated with ipsilateral severe extracranial carotid disease. Our findings suggest concomitant retinal and cerebral microvascular disease may be present in patients with carotid stenosis or occlusion disease. The pathogenesis of stroke due to carotid disease may thus be partially mediated by microvascular disease.
Design of Thermally Activated Delayed Fluorescent Assistant Dopants to Suppress the Nonradiative Component in Red Fluorescent Organic Light‐Emitting Diodes (2019)

Organic light-emitting diodes are currently under research to achieve high efficiency and long life by using thermally activated delayed fluorescence (TADF) materials. In particular, many studies have focused on ensuring high efficiency in fluorescent devices by introducing TADF materials. Herein, four kinds of orange-colored TADF materials were synthesized and introduced into 5,10,15,20-tetraphenylbisbenz[5,6]indeno[1,2,3-cd:1',2',3'-lm]perylene (DBP) red fluorescent devices as assistant dopants. These TADF materials assisted in achieving high efficiency in DBP devices by reducing nonradiative process by Dexter energy transfer and harvesting singlet excitons by a Förster resonance energy transfer process. Among the four TADF materials, 2-(3,5-di-tert-butylphenyl)-6-(9,9-diphenylacridin-10(9H)-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (DtBIQAP) showed a higher reverse intersystem crossing rate and a smaller nonradiative rate constant than the other two materials, which can reduce the exciton loss process. As a result, the DtBIQAP-assisted DBP device showed a high maximum external quantum efficiency of 18.2 % and color coordinates of (0.63, 0.37) in red fluorescent organic light-emitting diodes. This study provided a strategy of developing assistant dopants for high external quantum efficiency in TADF-assisted fluorescent devices.
Abstract 13439: Arteriogenesis is Impaired in CSEKO Mouse Hind Limb Ischemia Due to Attenuated Expression of Chemokines and Cytokines (2012)

Introduction Collateral growth due to arteriogenesis is a major mechanism to restore blood flow during chronic tissue ischemia. Arteriogenesis involves outward vascular remodeling of collateral art...
Two-Stage Power Conversion Architecture Suitable for Wide Range Input Voltage (2014)

This paper presents a merged-two-stage circuit topology suitable for either wide-range dc input voltage or ac line voltage at low-to-moderate power levels (e.g., up to 30 W). This two-stage topology is based on a soft-charged switched-capacitor preregulator/transformation stage and a high-frequency magnetic regulator stage. Soft charging of the switched capacitor circuit, zero voltage switching of the high-frequency regulator circuit, and time-based indirect current control are used to maintain high efficiency, high power density, and high power factor. The proposed architecture is applied to an LED driver circuit, and two implementations are demonstrated: a wide input voltage range dc-dc converter and a line interfaced ac-dc converter. The dc-dc converter shows 88%-96% efficiency at 30-W power across 25-200-V input voltage range, and the ac-dc converter achieves 88% efficiency with 0.93 power factor at 8.4-W average power. Contributions of this paper include: 1) demonstrating the value of a merged two-stage architecture to provide substantial design benefits in high-input voltage, low-power step down conversion applications, including both wide-range-input dc-dc and line-input ac-dc systems; 2) introduction of a multimode soft-charged SC stage for the merged architecture that enables compression of an 8:1 input voltage range into a 2:1 intermediate range, along with its implementation, loss considerations, and driving methods; and 3) merging of this topology with an resonant transition discontinuous-mode inverted buck stage and pseudocurrent control to enable step-down power conversion (e.g., for LED lighting) operating at greatly increased frequencies and reduced magnetics size than with more conventional approaches.
Sonochemical preparation of nanosized amorphous Fe-Ni alloys (1997)

Nanosized amorphous alloy powders of Fe20Ni80, Fe40Ni60, and Fe60Ni40 were prepared by sonochemical decomposition of solutions of volatile organic precursors, Fe(CO)5 and Ni(CO)4 in decalin, under an argon pressure of 100 to 150 kPa at 273 K. Magnetic susceptibility of Fe40Ni60 and Fe60Ni40 indicates blocking temperatures of 35 K and a magnetic particle size of about 6 nm. Thermogravimetric measurements of Fe20Ni80 give Curie temperatures of 322 °C for amorphous and 550 °C for crystallized forms. Differential scanning calorimetry exhibits an endothermic transition at 335 °C from a combination of the magnetic phase transition and alloy crystallization. The Mössbauer spectrum of crystallized Fe20Ni80 shows a sextet pattern with a hyperfine field of 25.04 T.
A Borehole Correction Model for Capture Gamma Ray Spectroscopy Logging Tools (1988)

Summary A borehole correction model, based onmore than 1,000 laboratory measurements, has been developed for logging tools that measure gamma ray energy spectra induced by the capture of thermal-energy neutrons. The measurements were made with a field-worthy tool incorporating a pulsed source of 14-MeV neutrons and a NaI(TI) gamma ray detector. In addition to the obvious geometric dependencies on borehole and casing sizes, the sensitivity of the measurement to elements within the borehole was found to depend just as strongly on the porosity and salinity of the borehole and formation fluids. The model decouples the geometric effects from most of the nuclear physics effects by explicitly including the time decay of the neutron flux in each homogeneous region.
Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography (2013)

Due to the wide use of animals for human disease studies, small animal whole-body imaging plays an increasingly important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose metabolic information, leading to higher costs of building dual-modality systems. Even with image coregistration, the spatial resolution of the metabolic imaging modality is not improved. We present a ring-shaped confocal photoacoustic computed tomography (RC-PACT) system that can provide both assessments in a single modality. Utilizing the novel design of confocal full-ring light delivery and ultrasound transducer array detection, RC-PACT provides full-view cross-sectional imaging with high spatial resolution. Scanning along the orthogonal direction provides three-dimensional imaging. While the mouse anatomy was imaged with endogenous hemoglobin contrast, the glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. Through mouse tumor models, we demonstrate that RC-PACT may be a paradigm shifting imaging method for preclinical research.