gebhart/patrepeval huggingface dataset:
Photoinduced charge-transfer process in rubidium manganese hexacyanoferrate probed by Raman spectroscopy (2009)

The photoinduced charge-transfer process in Rb(0.94)Mn[Fe(CN)(6)](0.98).0.2H(2)O is investigated by observing the valence states of the metal ions by Raman spectroscopy. The sample in the high-temperature phase is irradiated at the ligand to metal, CN(-)-->Fe(III) and charge-transfer band (lambda=395 nm). The Fe(III)-CN-Mn(II) pair valence state corresponding to the high-temperature configuration is totally depleted after prolonged irradiation, and the Fe(II)-CN-Mn(III) pair valence state corresponding to the low-temperature configuration appears. In addition, two kinds of CN stretching modes, ascribed to Fe(II)-CN-Mn(II) and Fe(III)-CN-Mn(III) pair valence states, are found. The photoproduction process of each pair valence states is well reproduced by a kinetic model assuming a charge transfer from Mn(II) to Fe(III). During irradiation, continuous shifts of the Raman peaks are found and ascribed to a release of the strain due to the lattice mismatching between the high-temperature and the photoinduced phases. This behavior indicates that the photoinduced phase created locally in the high-temperature-phase lattice grows up to a photoinduced phase domain. The conversion efficiency is lowered with decreasing temperature, indicating the existence of an energy barrier. We propose a model, which can explain the existence of an energy barrier in the electronic excited state.
Single-Pixel IQ Monitor via Computational Coherent Reception with Widely Linear Phase Retrieval (2020)

For in-service and in-field monitoring of frequency-dependent IQ imbalance in optical IQ modulators, we propose a low-complexity IQ monitor using a single photodetector based on phase retrieval. The feasibility of the proposed single-pixel IQ monitor was demonstrated experimentally with a 63.25-Gbaud 16QAM signal.
Degradation of Si/sub 1-x/Ge/sub x/ epitaxial heterojunction bipolar transistors by 1-MeV fast neutrons (1995)

Irradiation damage in n/sup +/-Si/p/sup +/-Si/sub 1-x/Ge/sub x//n-Si epitaxial heterojunction bipolar transistors (HBTs) by 1-MeV fast neutrons is studied as a function of fluence and germanium content for the first time. The degradation of the electrical performance of HBTs by irradiation increases with increasing fluence, while it decreases with increasing germanium content. The induced lattice defects in the base and the collector regions are studied by DLTS methods. In the base region, electron capture levels associated with interstitial boron are induced by irradiation, while two electron capture levels corresponding to the E centers and the divacancy are formed in the collector region. The degradation of device performance is then correlated with simulations of numbers of knock-on atoms. In order to examine the recovery behavior, isochronal thermal annealing is carried out for temperatures ranging from 75 to 300/spl deg/C. Based on the recovery of electrical performance, it is pointed out that the electron capture levels induced in the base and collector regions are mainly responsible for the increase of base current and the decrease of collector current.
From gene delivery and diagnostics to ecology (1996)

Introduction Liposomes: From Gene Delivery and Diagnostics to Ecology, D.D. Lasic and Y. Barenholz Liposomes in Gene Therapy, D.D. Lasic Structural Features of DNA-Cationic Liposome Complexes and Their Implication for Transfection, A. Minsky, R. Ghirlando, and H. Gershon Delivery of DNA, RNA, and Proteins by Cationic Liposomes, H. Farhood and L. Huang Advances in the Design and Application of Cytofectin Formulations, P.L. Felgner, Y.J. Tsai, and J.H. Felgner Gene Transfer to Plants by Lipofection and Electroporation, M. Maccarrone, A. Rossi, and A. Finazzi Agro The Contribution of Cationic Derivatives of Phospholipids and Cholesterol to the Bioadhesiveness of Liposomes and Their Transfection Performance, L.S.S. Guo, R. Radhakrishnan, and M. Man Liposomes in Cosmetics: How and Why?, G. Vanlerberghe Transport of Liposome Entrapped Molecules into the Skin as Studied by Electron Paramagnetic Resonance Imaging Methods, M. Sentjurc and V. Gabrijelcic Some Large-Scale, Non-Medical Applications of Non-Phospholipid Liposomes, D.F.H. Wallach and R. Mathur Liposomal Formulations of Agrichemical Pesticides, P.J. Quinn and S.F. Perrett Liposomes and Cheesemaking, P. Dufour, E. Laloy, J.-C. Vuillemard, and R.E. Simard Use of Liposomes for Wool Dyeing, A. de la Maza, L. Coderch, A.M. Manich, P. Bosch, and J.L. Parra Liposomes as a Model System to Study Shark Repellency, E. Kalmanzon, E. Zlotkin, and Y. Barenholz Use of Antigen-Coupled Liposomes for Homogeneous Immunoassays of Polyclonal Antibody, S. Katoh, M. Kishimura, and H. Fukuda Liposomes in Immunodiagnostics, A.K. Singh and R.G. Carbonell Steric Stabilization of Liposomes Improves Their Use in Diagnostics, N. Emanuel, E. Kedar, O. Toker, E. Bolotin, and Y. Barenholz Liposome-Amplified Immunodetermination of Environmental Contaminants, S.G. Reeves, S.T.A. Siebert, and R.A. Durst The Use of Liposomes in Biodegradability Testing, R.M. Miller, I.Y. Jimenez, and R. Bartha Microbe Entrapment in Giant Liposomes, G. Gregoriadis, I. Gursel, and S.G. Antimisiaris Liposomes as a Model for Membrane Structures and Structural Transformations: A Liposome Album, B. Sternberg Liposomes: Past, Present, and Future, D.D. Lasic and Y. Barenholz
Partitioning of copy-number genotypes in pedigrees (2010)

CNGen is the first published software for the partitioning of copy number genotypes in pedigrees, making possible the use CNPs and CNVs for linkage analysis. It was implemented with the Python interpreter version 2.5.2. It was successfully tested on current Linux, Windows and Mac OS workstations.
Virtual Texture Mapping 101 (2010)

From the literature, we may extract two diﬀerent approaches: object-space and image-space algorithms. However, most modern algorithms work in either image space or hybrid space. For the purposes of this chapter, we are interested in GPU-based algorithms, and these are the ones we will present. Werefer the interested reader to the works of [Isenberg et al. 03] and [Hartner et al. 03] for overviews and deep comparisons on CPU-based silhouette extraction algorithms.
Animal Models of Cerebral Ischemia (1998)

Stroke remains a leading cause of death in the US, killing more than two of every five Americans (1). There are 500,000 cases of stroke each year, of which 400,000 are ischemic (2). Approximately 20% of the people who suffer a stroke die in the first week. However, more than 70% of stroke patients survive long term. There were an estimated 2,920,000 stroke survivors in 1988 (1). The economic cost of cerebrovascular disease in 1993 was estimated to be $117.4 billion, including costs of physician, nursing, hospital and nursing home services, medications, and lost productivity (3). Many patients, as well as their families, are devastated, since patients are often severely incapacitated with physical and mental disabilities. This health problem will continue to increase as the population of the US ages. It is important to rehabilitate stroke patients, so that they are as independent as possible with activities of daily living (2).
It Failure and the Collapse of One.Tel (2002)

There are a number of cases about IS failure. However, few suggest that the IS failure led to the downfall of the business. This paper examines the information technology strategies employed by the high-profile Australian telecommunications company One.Tel Limited and assesses the extent to which a failure of those strategies may have contributed to, or precipitated, One.Tel’s downfall. With increased reliance on technology in business and its sophistication, potentially catastrophic failures may be more common in the future One.Tel was founded in 1995 as an Australian telecommunication company and ceased trading in 2001. In the middle of 1999, the focus of the company changed towards the building of a global business, geared to the delivery of media content. We argue that the IT strategies operating within One.Tel were not adapted to meet the rapid growth that ensued. Further, we suggest that the information technology approaches that had served adequately in the early years were not appropriate for its later ambitions. Most importantly, we discuss the failure of its billing system in relation to published frameworks of IT failure as well as the importance of getting such basic systems right. We argue that these frameworks do not cover well the One.Tel case and we put forward a new category of IT failure, that of ‘business ethos’
Calculation of the missing mode effect frequencies from Raman intensities (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of the missing mode effect frequencies from Raman intensitiesLee Tutt, David Tannor, John Schindler, Eric J. Heller, and Jeffrey I. ZinkCite this: J. Phys. Chem. 1983, 87, 16, 3017–3019Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/j100239a010https://doi.org/10.1021/j100239a010research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Triple-doped white organic light-emitting devices grown in vacuum (2004)

We demonstrate efficient (&#951;<sub>p</sub>=11±1 lm/W at 1000 cd/m<sup>2</sup>), bright electrophosphorescent white organic light emitting devices (WOLEDs) employing three dopants in a 9-nm-thick inert host matrix. The emissive layer consists of 2 wt.% iridium (III) bis(2-phenyl quinolyl-N,C<sup>2'</sup>) acetylacetonate (PQIr), 0.5 wt.% <i>fac</i>-tris(2-phenylpyridine) iridium (Ir(ppy)<sub>3</sub>) and 20 wt.% bis(4’,6’-difluorophenylpyridinato)tetrakis(1-pyrazolyl)borate (FIr6) co-doped into a wide energy gap <i>p</i>-bis(triphenylsilyly)benzene (UGH2) host. Devices were characterized in terms relevant to both display and general lighting applications, and have a peak total power efficiency of 42±4 lm/W at low intensities, falling to 10±1 lm/W at a drive current of 20 mA/cm<sup>2</sup> (corresponding to 1.4 lm/cm<sup>2</sup> for an isotropic illumination source). The Commission Internationale de l’Eclairage coordinates shift from (0.43,45) at 0.1 mA/cm<sup>2</sup> to (0.38,0.45) at 10 mA/cm<sup>2</sup>, and a color rendering index >75 is obtained. Three factors contribute to the high efficiency: thin layers leading to low voltage operation, a high quantum efficiency blue dopant, and efficient confinement of charge and excitons within the emissive region. The highest occupied and lowest unoccupied energy levels of component layers will be discussed to elucidate charge and exciton confinement within the emissive layer. Additionally, we will explain energy transfer between dopants based on photoluminescent transient analysis of triple-doped thin films.
Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD (2010)

An inflammatory component is present in the microenvironment of most neoplastic tissues, including those not causally related to an obvious inflammatory process. Several microRNAs, and especially miR-155, play an essential role in both the innate and adaptative immune response. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant with anti-inflammatory properties that is currently at the stage of preclinical studies for human cancer prevention. Here, we establish that, in human THP-1 monocytic cells as well as in human blood monocytes, resveratrol upregulates miR-663, a microRNA potentially targeting multiple genes implicated in the immune response. In THP-1 cells, miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs its upregulation by lipopolysaccharides (LPS), at least in part by directly targeting JunB and JunD transcripts. We further establish that the downregulation of AP-1 activity by resveratrol is miR-663 dependent and that the effects of resveratrol on both AP-1 activity and JunB levels are dose dependent. Finally, we show that resveratrol impairs the upregulation of miR-155 by LPS in a miR-663-dependent manner. Given the role of miR-155 in the innate immune response and the fact that it is upregulated in many cancers, our results suggest that manipulating miR-663 levels may help to optimize the use of resveratrol as both an anti-inflammatory and anticancer agent against malignancies associated with high levels of miR-155.
Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia (2023)

Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
Supplemental Figures and Tables from Syntaphilin Regulates Neutrophil Migration in Cancer (2023)

&lt;p&gt;Supplemental Figures, legends and tables&lt;/p&gt;
An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale (2021)

While the Transformer architecture has become the de-facto standard for natural language processing tasks, its applications to computer vision remain limited. In vision, attention is either applied in conjunction with convolutional networks, or used to replace certain components of convolutional networks while keeping their overall structure in place. We show that this reliance on CNNs is not necessary and a pure transformer applied directly to sequences of image patches can perform very well on image classification tasks. When pre-trained on large amounts of data and transferred to multiple mid-sized or small image recognition benchmarks (ImageNet, CIFAR-100, VTAB, etc.), Vision Transformer (ViT) attains excellent results compared to state-of-the-art convolutional networks while requiring substantially fewer computational resources to train.
A piezoelectric transformer based inverter topology for immerging CCFL inverter (2008)

In this paper, different CCFL (Cold Cathode Fluorescent Lamp) inverter topologies are discussed and analyzed and are compared to the piezoelectric transformer based topology. One of the main concerns is how to over come the negative resistance and parasitic capacitance effects in each topology. CCFL tubes and their construction are described to understand the tubes electrical characteristics. Due to its size, luminance, life and efficiency, CCFLs are the preferred source of illumination for larger LCD panels. There are different well established topologies of inverters that are used to drive the CCFL. These include the Royer self resonant oscillator, Push-Pull, and Full bridge inverter. The challenge in designing an inverter is to overcome the negative resistance characteristics of the tubes and to compensate for the parasitic capacitance. These issues are discussed in detail. A driver for the tube has been simulated and implemented in the lab. The design considers the negative resistance and parasitic capacitance issues.
Experimental verification of the penalty produced by polarization effects in fiber recirculating loops (2003)

We use optical fiber recirculating loop experiments to validate a reduced Stokes model that allows us to compute the penalty produced by polarization effects in single-channel and wavelength-division multiplexed systems.
13C and 2D NMR Analysis of Propylene Polymers Made with α-Diimine Late Metal Catalysts (2000)

Late transition metal catalysts bearing α-diimine ligands allow ethylene and α-olefin homo- and copolymerizations to polyolefins with unprecedented structures. The polypropylenes made with these new late metal catalysts have very complex microstructures that include combinations of features not seen in any known polypropylenes. These unusual structures include long branches, branches on branches including isobutyl branches, and moderate highly variable levels of 1,3-enchainment leading to runs of methylenes in the backbone of many different well-defined lengths. These features vary with the nature of the catalyst used for polymerization and with the polymerization conditions. Many of the polypropylenes are made primarily by 1,2-insertions to give syndiotactic placements via chain end control. A mechanistic description of catalyst behavior has been developed to explain these observed microstructures.
Nanopore/Multilayer Isotope Batteries Using Radioisotopes from Nuclear Wastes (2010)

Nuclear (“isotope”) batteries of various sorts based on a variety of radioisotopes have been studied for over 50 years. They can play a mission-critical role when other power sources cannot fulfill the demanding requirements for maintenance free ultra long life operation. However, the conversion efficiency and power level are often far from that desired so that their applications in the civilian market have been quite limited, although some military and NASA space uses have occurred. The typically high costs of prior isotope batteries have further exacerbated the problem. Meanwhile, the handling and storage of nuclear waste have become both a technological and a political issue. In the present paper we discuss use of isotopes from nuclear wastes to power nuclear batteries, lowering their costs and providing an important use for key isotopes from nuclear waste. However, these isotopes are not “ideal” for such use, so improved nuclear battery design must be developed to provide a useful battery. The present reference design is based on the most abundant isotope pair available in fission products, Sr-90/Y-90. Other waste isotopes could be used in later designs once this approach is successfully demonstrated from Sr-90/Y-90.
Unique Remodeling Processes after Vascular Injury in Intracranial Arteries: Analysis Using a Novel Mouse Model (2013)

The effectiveness of angioplasty and stenting in intracranial atherosclerotic diseases is controversial due to high rates of delayed restenosis and hemorrhage compared with extracranial arteries. However, the mechanisms underlying these differences are still unclear, because their pathophysiology is yet to be examined. To address this issue, we established a novel vascular injury model in the intracranial internal carotid arteries (IICAs) in mice, and analyzed the remodeling process in comparison to that of the femoral arteries (FAs). In IICAs, neointimal hyperplasia was observed from day 14 and grew until day 56. Although smooth muscle cells (SMCs) emerged in the neointima from day 28, SMCs in the injured media were continuously lost with eventual extinction of the media. Re-endothelialization was started from day 7 and completed on day 28. Accumulation of macrophages was continued in the adventitia until day 56. Compared with FAs, the following points are unique in IICAs: (1) delayed continuous formation of neointima; (2) accumulation of macrophages in the media on day 14; (3) continuous loss of SMCs in the media followed by extinction of the media itself; and (4) continuously growing adventitia. These pathophysiologic differences might be associated with unfavorable outcomes in percutaneous transluminal angioplasty and stenting in intracranial arteries.
1177 Identification of and vaccination with antigen specific Th1 selective epitopes in bladder cancer: a step towards a multi-antigen vaccine for bladder cancer prevention (2022)

<h3>Background</h3> Bladder cancer is a frequently diagnosed malignancy. Half of patients responding to standard therapy develop recurrence within 5 years. Vaccination for secondary prevention of bladder cancer could reduce recurrence. We developed an epitope identification approach for vaccine construction from non-mutated tumor associated proteins combining in silico prediction of Class II epitopes with functional screening to edit out sequences inducing regulatory responses. The method allows the identification of Th1 selective epitopes which elicit an antigen specific IFN-gamma response without IL-10 secretion. We aimed to identify bladder cancer antigens and determine Class II binding peptides for use in a multi-antigen Th1 selective vaccine. <h3>Methods</h3> Seven datasets (GEO); 38 normal bladder, 229 NMIBC and 86 muscle invasive non-metastatic bladder cancers were studied. Genes with at least 2-fold upregulation in cancer compared to normal with a corrected p-value &lt; 0.1 and found in &gt;50% of cancer samples were identified (n=159). We prioritized those upregulated in &gt;75% of cancers (n=15). Nine genes encoded proteins with known overexpression in human bladder cancer; CDC20, TOP2A, CCNB2, MAPK13, CDK1, AURKA, CEP55, PRC1, and MELK. We evaluated expression by IHC in OH-BBN induced mouse bladder tumors. Eight proteins were expressed in tumors and the murine MB49 bladder cancer cell line. Using a multi-algorithm approach, we selected 24 putative class II epitopes, associated with high binding affinity across multiple MHC class II alleles, derived from these proteins. All epitopes had &gt;88% homology between species. <h3>Results</h3> We screened PBMC (12 donors/9 bladder cancer patients) by IFN-g/IL-10 ELISPOT. Th1 selective epitopes were identified for 5 antigens, CDC20, TOPO2A, CCNB2, CDK1, and CEP55. We evaluated immunogenicity of single-antigen vaccines in C57BL6 mice to identify any epitopes inducing selective Th1 immunity. Five peptides generated significant antigen-specific Th1 with no evidence of Th2. To evaluate anti-tumor activity, single-antigen vaccines were given four times, two weeks apart, with CFA/IFA. Two weeks after vaccination, mice were implanted with MB49. All vaccines could significantly inhibit tumor growth as compared to PBS control; CDC20 (p=0.0001), TOPO2A (p&lt;0.0001), CCNB2 (p&lt;0.0001), CDK1 (p&lt;0.0001), and CEP55 (p&lt;0.0001). We admixed epitopes into a single vaccine, BLADVAC, immunizing mice to discern epitope competition. Significantly elevated levels of antigen-specific IFN-g secreting T-cells were detected for all epitopes except CDK1 (p&lt;0.001 compared to HIV control). <h3>Conclusions</h3> We identified bladder cancer antigens covering the majority of tumors with clinically effective Th1 selective vaccines constructed. Prevention trials in the OH-BBN model are ongoing.