gebhart/patrepeval huggingface dataset:
SAT-LB023 Elevated Fasting Plasma Glucose Predicts Higher Odds For Becoming A Super-responder With Gelesis100 In The GLOW Pivotal Weight-loss Study (2019)

Background: In a previous pilot weight-loss study, an association was observed between baseline fasting plasma glucose (FPG) levels and the effectiveness of the Gelesis100 treatment. The aim of this subanalysis of the Gelesis Loss Of Weight (GLOW; NCT02307279) study is to further assess the association between FPG and body weight (BW) responders in subjects with overweight or obesity treated with Gelesis100, a non-systemic hydrogel. Methods: This subanalysis was conducted in subjects who were overweight or had obesity and who completed the GLOW study. GLOW was a multicenter, double-blind, placebo-controlled pivotal study with subjects randomized to 2.25 g of Gelesis100 or placebo in capsules taken with 500 mL of water before lunch and dinner while on a hypocaloric diet (-300 kcal/day) for 24 weeks. BW responders at 5% and 10% (super-responders) were analyzed using Logit model comparing Gelesis100 to placebo arms in 2 subgroups of subjects defined by their initial FPG (two consecutive consistent values). Subgroup 1 had normoglycemia (FPG < 100 mg/dL) and subgroup 2 had prediabetes (PD) (FPG ≥ 100 mg/dL and < 126 mg/dL) or untreated type 2 diabetes (T2D) (FPG ≥ 126 mg/dL). Results: The population included 206 subjects (94 males, 112 females, 138 in subgroup 1, 68 in subgroup 2, 105 on Gelesis100, 101 on placebo). In subgroup 1 (mean baseline FPG = 91 mg/dL), BW responders at 5% and 10% in Gelesis100 arm were 60% (placebo arm = 34%, adjusted odds ratio (OR) = 3.1, P = 0.0022) and 22% (placebo arm = 15%, OR = 1.5, P = 0.4254), respectively. In subgroup 2 (mean baseline FPG = 113 mg/dL), BW responders at 5% and 10% in Gelesis100 arm were 72% (placebo arm = 56%, OR = 2.2, P = 0.1509) and 44% (placebo arm = 14%, OR = 6.1, P = 0.0071), respectively. In the overall population, baseline FPG was inversely correlated with BW percent change in the Gelesis100 arm (r = -0.24, P = 0.0144). The safety and tolerability of Gelesis100 demonstrated no increased risk compared to placebo. No serious adverse events were observed in any arm. Conclusion: Gelesis100 offers a compelling new approach in the management of overweight and obesity. Notably, in Gelesis100-treated subjects with PD or untreated T2D, the odds of being super-responders are 6 times higher compared to placebo. This finding may be used as a tool for identifying subjects who are both at higher clinical risk and more likely to achieve greater levels of BW loss when treated with Gelesis100. The mechanisms underlying this finding require further investigations. Unless otherwise noted, all abstracts presented at ENDO are embargoed until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.
Narrow-line ytterbium fiber master-oscillator power amplifier (2002)

We present modeled and experimental results for an ytterbium-doped fiber amplifier seeded with a narrow-linewidth master oscillator. We include a simplified model used to generate input for a model that numerically solves the coupled differential equations. We find good agreement between the model and measured data.
Supplementary material : Rapid synthesis of cross-bridged cyclam chelators for copper(II) complex formation (2013)

Comptes Rendus Chimie - In Press.Proof corrected by the author Available online since samedi 30 mars 2013
Serial Communication Based Distributed Control of the Stacked Polyphase Bridges Converter (2016)

In recent years, the stacked polyphase bridges converter has gained increasing interest due to its modularity and scalability for different power and voltage levels. To maintain the advantages from ...
Personalized Search (2016)

Traditionally search engines have returned the same results to everyone who asks the same question. However, using a single ranking for everyone in every context at every point in time limits how well a search engine can do in providing relevant information. In this talk I present a framework to quantify the "potential for personalization" which we use to characterize the extent to which different people have different intents for the same query. I describe several examples of how we represent and use different kinds of contextual features to improve search quality for individuals and groups. Finally, I conclude by highlighting important challenges in developing personalized systems at Web scale including privacy, transparency, serendipity, and evaluation.
Evolution of a reassortant North American gull influenza virus lineage: drift, shift and stability (2013)

This process appears similar to genetic shifts seen with swine influenza where a stable "triple reassortant internal gene" core has circulated in swine populations with genetic shifts occurring with hemaggluttinin and neuraminidase proteins getting periodically switched. Thus gulls may serve as genetic mixing vessels for different lineages of avian influenza, similar to the role of swine with regards to human influenza. These findings illustrate the need for continued surveillance in gull and waterfowl populations, both on the Pacific and especially Atlantic coasts of North America, to document virus intercontinental movement and the role of gull species in the evolution and epidemiology of AI.
Discrimination of Left Atrial and Pulmonary Vein Potentials in Patients with Paroxysmal Atrial Fibrillation (2003)

Atrial and PV potentials acquired from a multielectrode basket catheter can be discriminated using the normalized slopes of bipolar and quadripolar electrograms. These additional parameters need to be included by physicians determining the preferential ablation site within PVs.
OPTIMIZATION OF GRADED BANDGAP Cd1-xZnxTe THIN FILM SOLAR CELLS FROM NUMERICAL ANALYSIS (2014)

Solar cells based on CdTe have reached a maximum practical recorded efficiency of 20.4%, which is low compared to its theoretical limit (29%). Novel concepts are required to further increase the efficiency of CdTe based solar cells. One possible approach is the graded bandgap CdZnTe solar cells. The commercial CdTe solar cells usually have thicker absorber layer. However, by using graded bandgap CdZnTe the absorber layer thickness can be reduced significantly, which eventually will reduce the cost, save processing time and energy required for fabrication. In this work, numerical simulation on graded bandgap CdZnTe solar cells is carried out by AMPS-1D software. The absorber layer of graded bandgap CdZnTe solar cells are optimized by two approaches (A and B), where each approach has four optimized structures. Finally, one optimized cell structure is selected for each approach. The results of the best cells for approach A and B are Voc= 0.884 Volt, Jsc= 32.074 mA/cm 2
Monitoring multistage integrated circuit fabrication processes (1996)

This paper presents a process monitoring system, which is designed to be used for monitoring VLSIC and other multistage manufacturing processes. The proposed process monitor can 1) simultaneously detect a variety of out-of-control conditions, 2) quantify the magnitude of process change, and 3) be used to compute the probability of meeting specifications. Average run length simulations show that for a single-stage process, the monitor is at least as good as the Shewhart-CUSUM charts for detecting changes in the distribution of the monitored characteristics. For a multistage process, however, the Bayesian monitor can significantly reduce the detection time by using in-line correlation information from earlier stages. The monitor has been applied to data from a state-of-the-art fabrication facility, and the results are promising.
Highlights of statistical signal and array processing (1998)

The Statistical Signal and Array Processing Technical Committee (SSAP-TC) deals with signals that are random and processes an array of signals simultaneously. The field of SSAP represents both solid theory and practical applications. Starting with research in spectrum estimation and statistical modeling, study in this field is always full of elegant mathematical tools such as statistical analysis and matrix theory. The area of statistical signal processing expands into estimation and detection algorithms, time-frequency domain analysis, system identification, and channel modeling and equalization. The area of array signal processing also extends into multichannel filtering, source localization and separation, and so on. This article represents an endeavor by the members of the SSAT-TC to review all the significant developments in the field of SSAP. To provide readers with pointers for further study of the field, this article includes a very impressive bibliography-close to 500 references are cited. This is just one of the indications that the field of statistical signals has been an extremely active one in the signal processing community. The article also introduces the recent reorganization of three technical committees of the Signal Processing Society.
The human HOX gene family (1989)

We report the identification of 10 new human homeobox sequences. Altogether, we have isolated and sequenced 30 human homeoboxes clustered in 4 chromosomal regions called HOX loci. HOX1 includes 8 homeoboxes in 90 kb of DNA on chromosome 7. HOX2 includes 9 homeoboxes in 180 kb on chromosome 17. HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12. Finally, HOX4 includes 6 homeoboxes in 70 kb on chromosome 2. Homeodomains obtained from the conceptual translation of the isolated homeoboxes can be attributed to 13 homology groups on the basis of their primary peptide sequence. Moreover, it is possible to align the 4 HOX loci so that corresponding homeodomains in all loci share the maximal sequence identity. The complex of these observations supports and extends an evolutionary hypothesis concerning the origin of mammalian and fly homeobox gene complexes. We also determined the coding region present in 3 HOX2 cDNA clones corresponding to HOX2G, HOX2H and HOX2I.
Integrated circuit security techniques using variable supply voltage (2011)

This paper addresses integrated circuit (IC) security issues by using supply voltage based gate-level characterization (GLC). Our GLC scheme is capable of characterizing both manifestation and physical level properties of an IC accurately using variable supply voltage. We demonstrate that the proposed scheme can detect three types of IC attacks with low false positives and false negatives.
Discovery of 4‐Aryl‐4H‐chromenes as a New Series of Apoptosis Inducers Using a Cell‐ and Caspase‐Based Hight‐Throughput Screening Assay. Part 2. Structure—Activity Relationships of the 7‐ and 5‐, 6‐, 8‐Positions. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor (2012)

The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) synergizes the cytotoxic effect of doxorubicin (Dox) and anti-HER2 on mammary carcinoma cells while protecting normal cells against their insults. This study investigated the concomitant changes occurring in heart tissue and tumors of mice bearing a subcutaneous 4T1 mammary tumor following treatment with AN-7, Dox, or their combination. Dox or AN-7 alone led to inhibition of both tumor growth and lung metastases, whereas their combination significantly increased their anticancer efficacy and attenuated Dox- toxicity. Molecular analysis revealed that treatment with Dox, AN-7, and to a greater degree, AN-7 together with Dox increased tumor levels of γH2AX, the marker for DNA double-strand breaks and decreased the expression of Rad51, a protein needed for DNA repair. These events culminated in increased apoptosis, manifested by the appearance of cytochrome-c in the cytosol. In the myocardium, Dox-induced cardiomyopathy was associated with an increase in γH2AX expression and a reduction in Rad51 and MRE11 expression and increased apoptosis. The addition of AN-7 to the Dox treatment protected the heart from Dox insults as was manifested by a decrease in γH2AX levels, an increase in Rad51 and MRE11 expression, and a diminution of cytochrome-c release. Tumor fibrosis was high in untreated mice but diminished in Dox- and AN-7-treated mice and was almost abrogated in AN-7+Dox-treated mice. By contrast, in the myocardium, Dox alone induced a dramatic increase in fibrosis, and AN7+Dox attenuated it. The high expression levels of c-Kit, Ki-67, c-Myc, lo-FGF, and VEGF in 4T1 tumors were significantly reduced by Dox or AN-7 and further attenuated by AN-7+Dox. In the myocardium, Dox suppressed these markers, whereas AN-7+Dox restored their expression. In conclusion, the combination of AN-7 and Dox results in two beneficial effects, improved anticancer efficacy and cardioprotection.
Diazonium Salts as Grafting Agents and Efficient Radical‐Hydrosilylation Initiators for Freestanding Photoluminescent Silicon Nanocrystals (2014)

The reactivity of diazonium salts towards freestanding, photoluminescent silicon nanocrystals (SiNCs) is reported. It was found that SiNCs can be functionalized with aryl groups by direct reductive grafting of the diazonium salts. Furthermore, diazonium salts are efficient radical initiators for SiNC hydrosilylation. For this purpose, novel electron-deficient diazonium salts, highly soluble in nonpolar solvents were synthesized. The SiNCs were functionalized with a variety of alkenes and alkynes at room temperature with short reaction times.
Amlodipine-Induced Reduction of Oxidative Stress in the Brain Is Associated with Sympatho-Inhibitory Effects in Stroke-Prone Spontaneously Hypertensive Rats (2006)

Amlodipine is a dihydropyridine calcium channel blocker that is widely used for the treatment of hypertensive patients and has an antioxidant effect on vessels in vitro. The aim of the present study was to examine whether treatment with amlodipine reduced oxidative stress in the brains of stroke-prone spontaneously hypertensive rats (SHRSP). The animals received amlodipine, nicardipine or hydralazine for 30 days in their drinking water. Levels of thiobarbituric acid-reactive substances (TBARS) in the brain (cortex, cerebellum, hypothalamus, and brainstem) were measured before and after each treatment. Systolic blood pressure decreased to similar levels in the amlodipine-, nicardipine-, and hydralazine-treated groups. Urinary norepinephrine excretion was significantly reduced in SHRSP after treatment with amlodipine, but not with nicardipine or hydralazine. Levels of TBARS in the cortex, cerebellum, hypothalamus, and brainstem were significantly higher in SHRSP than in Wistar-Kyoto rats (WKY), and were reduced in amlodipine-treated, but not in nicardipine- or hydralazine-treated, SHRSP. Electron spin resonance spectroscopy revealed increased levels of reactive oxygen species in the brains of SHRSP, which were reduced by treatment with amlodipine. Intracisternal infusion of amlodipine also reduced systolic blood pressure, urinary norepinephrine excretion, and the levels of TBARS in the brain. These results suggested that oxidative stress in the brain was enhanced in SHRSP compared with WKY rats. In addition, antihypertensive treatment with amlodipine reduced oxidative stress in all areas of the brain examined and decreased blood pressure without a reflex increase in sympathetic nerve activity in SHRSP.
GC×GC Analysis of Novel 2α-Methyl Biomarker Compounds from a Large Middle East Oilfield (2022)

Comprehensive two-dimensional gas chromatography coupled with high resolution time-of-flight mass spectrometry (GC×GC-HRT) was used to explore and compare the chemical complexity of hopanoids and degradation products of hopanoid parent molecules in the heavy oil rim of a large Middle East oilfield. In particular, GC×GC-FID, GC×GC-ToF, and GC×GC-HRT enabled an in-depth characterization of the types and families of GC-amenable hopanoids and 2α-methyl hopanoids along with degradation products derived from these compounds. Here we identify 2α-methyl analogs of 8,14-secohopanoids, 2α-methyl analogs of sesquiterpanoids, a 2α-methyl tetracyclic terpanoid, as well as 2α-methyl analogs of hopanoids and benzohopanoids. The compounds identified in this study are useful transformation products by various processes on the parent hopanoid compounds. This type of information provides valuable means to investigate reservoir complexities such as connectivity analysis.
ChemInform Abstract: Synthesis and SAR of Benzamidine Factor Xa Inhibitors Containing a Vicinally‐Substituted Heterocyclic Core. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Using Liquid Crystals to Probe the Organization of Helical Polypeptide Brushes Induced by Solvent Pretreatment (2021)

Grafted polymer brushes form the basis of a versatile class of surfaces with properties that can be tailored via choice of the chemical functional groups or architecture of the grafted polymers. Here, we explore how treatment by solvents can program the organization of homopolymer brushes comprising helical poly(γ-benzyl-l-glutamate) (PBLG) and how the orientational behavior of liquid crystals (LCs) contacted with the brushes can provide fresh insights into brush organization. We treated PBLG brushes with either good (chloroform) or poor (acetone) solvents to form collapsed or teepee-like grafted polymer organizations, respectively. When supported on PBLG brushes with thicknesses [determined by atomic force microscopy (AFM)] of 50 nm, we found that collapsed and teepee-like brushes induced planar (parallel to surface) and homeotropic (perpendicular to surface) orientations of nematic LCs, respectively. By preparing solvent-pretreated brushes with a range of thicknesses (12–140 nm), and by combining insights based on AFM, Fourier-transform infrared spectroscopy and LCs, we found that a continuous change in tilt of the LC is accompanied by a continuous change in tilt of the PBLG chains, as influenced by the teepee-like organization. The role of PBLG chain orientation in dictating the LC orientation was confirmed by additional experiments in which PBLG brushes were thermally denatured. Finally, when using mixed solvents (mixtures of chloroform and acetone) to manipulate the PBLG brush organization, we observed LCs to exhibit patterned orientations on the micrometer scale, consistent with patterned orientations of the PBLG chains imprinted by droplets formed during the mixed solvent drying process. Overall, these results expand our understanding of the range of PBLG brush organizations that can be induced by solvent pretreatment and demonstrate the utility of LCs for imaging PBLG chain orientation within brushes.
Hypervector Design for Efficient Hyperdimensional Computing on Edge Devices (2021)

Hyperdimensional computing (HDC) has emerged as a new light-weight learning algorithm with smaller computation and energy requirements compared to conventional techniques. In HDC, data points are represented by high-dimensional vectors (hypervectors), which are mapped to high-dimensional space (hyperspace). Typically, a large hypervector dimension ($\geq1000$) is required to achieve accuracies comparable to conventional alternatives. However, unnecessarily large hypervectors increase hardware and energy costs, which can undermine their benefits. This paper presents a technique to minimize the hypervector dimension while maintaining the accuracy and improving the robustness of the classifier. To this end, we formulate the hypervector design as a multi-objective optimization problem for the first time in the literature. The proposed approach decreases the hypervector dimension by more than $32\times$ while maintaining or increasing the accuracy achieved by conventional HDC. Experiments on a commercial hardware platform show that the proposed approach achieves more than one order of magnitude reduction in model size, inference time, and energy consumption. We also demonstrate the trade-off between accuracy and robustness to noise and provide Pareto front solutions as a design parameter in our hypervector design.
Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates (2008)

Based on previous preclinical evaluation in mice and monkeys, the chimeric TBEV/DEN4Delta30 virus, carrying the prM and E protein genes from a highly virulent Far Eastern strain of tick-borne encephalitis virus (TBEV) on the backbone of a nonneuroinvasive dengue type 4 virus (DEN4), has been identified as a promising live attenuated virus vaccine candidate against disease caused by TBEV. However, prior to use of this vaccine candidate in humans, its neurovirulence in nonhuman primates needed to be evaluated. In the present study, we compared the neuropathogeneses of the chimeric TBEV/DEN4Delta30 virus; Langat virus (LGTV), a former live TBEV vaccine; and yellow fever 17D virus vaccine (YF 17D) in rhesus monkeys inoculated intracerebrally. TBEV/DEN4Delta30 and YF 17D demonstrated remarkably similar spatiotemporal profiles of virus replication and virus-associated histopathology in the central nervous system (CNS) that were high in cerebral hemispheres but progressively decreased toward the spinal cord. In contrast, the neurovirulence of LGTV exhibited the reverse profile, progressing from the site of inoculation toward the cerebellum and spinal cord. Analysis of the spatiotemporal distribution of viral antigens in the CNS of monkeys revealed a prominent neurotropism associated with all three attenuated viruses. Nevertheless, TBEV/DEN4Delta30 virus exhibited higher neurovirulence in monkeys than either LGTV or YF 17D, suggesting insufficient attenuation. These results provide insight into the neuropathogenesis associated with attenuated flaviviruses that may guide the design of safe vaccines.
Blind Adaptation of Partial Response Equalizers for 200Gb/s per Lane IM/DD Systems (2021)

We propose a novel non-data-aided adaptation algorithm for a partial-response feed-forward equalizer. Performance is evaluated based on 224Gb/s PAM4 signals captured after 0km and 20km O-band transmission suitable for hyper-scale datacenter intra-connections.
Isolation and Characterization ofStreptococcrcs SuisCapsular Types 9-22 (1991)

The incidence and biochemical patterns of Streptococcus suis capsular types 9-22 are presented. Of 148 untypeable (with types 1-8 antisera) isolates of S. suis recovered from diseased pigs, 10% were not capsulated. Of the remaining 134 isolates, only 53% belonged to capsular types 9-22; capsular types 22 and 9 were the most prevalent, representing 19% and 13%, respectively. Capsular type 15 (de Moor's group T Streptococcus) is reported here for the first time in North America since it was described in 1963 in Europe. Of 188 untypeable isolates recovered from clinically healthy pigs, 25% were noncapsulated. Of the remaining 141 isolates, 90% belonged to the new capsular types, and 87% were identified as 1 of 4 types: 17, 18, 19, and 21. Capsular types 12 and 20 were not detected among the Canadian isolates. Almost half of strains were arginine dihydrolase-negative, and 45% fermented mannitol, which is seldom a positive test with capsular types 1-8. Although some strains were negative with salicin or trehalose, none were negative for both sugars. Only 54% of isolates tested with 1 rapid multitest system were correctly identified as S. suis. A tentative biochemical profile that might be used with a microplate identification system is also presented. Biochemical identification using the conventional system instead of the rapid multitest system is preferable.