gebhart/patrepeval huggingface dataset:
Cytochrome P‐450 2J epoxygenase gene function in murine hypoxic pulmonary vasoconstriction (HPV) (2012)

Recent studies suggest that cytochrome P‐450 (CYP) epoxygenase‐derived epoxyeicosatrienoic acids (EETs) play an important role in the regulation of the pulmonary vascular tone. To assess the role of the CYP2J‐signaling pathway in HPV, we studied CYP2J +/+ and CYP2J −/− mice, as well as CYP2J −/− mice carrying a transgene specifying human CYP2J (CYP2J −/− ‐Tg). Mice were anesthetized, intubated, and ventilated at F I O 2 =1. After thoracotomy, pulmonary artery pressure (PAP) and left lung blood flow (QLPA) were measured before and during transient inferior vena cava occlusion. Left pulmonary vascular resistance (LPVR) was calculated from the slope of the PAP‐QLPA relationship. The pulmonary vasoconstrictor response to unilateral left lung hypoxia was estimated by comparing LPVR before and after left main stem bronchial occlusion (LMBO). LMBO increased LPVR in CYP2J +/+ and CYP2J −/− ‐Tg mice but not in CYP2J −/− mice (see Table). P a O 2 during LMBO was greater in CYP2J +/+ and CYP2J −/− ‐Tg mice than in CYP2J −/− mice. Administration of MS‐PPOH, a selective inhibitor of CYP‐mediated epoxygenation, blocked the ability of LMBO to increase LPVR in CYP2J +/+ mice. Taken together, these results indicate that CYP2J epoxygenase contributes importantly to HPV in mice. (Supported by MGH, Department of Anesthesia, Critical Care and Pain Medicine).
1432 Discovery of HIO 3 a tumor-produced protein that binds the human IgG1 Fc CH3 domain and suppresses antibody dependent cellular cytotoxicity and complement dependent cytotoxicity (2022)

<h3>Background</h3> Human cancers employ a number of mechanisms to evade host immune responses against novel antigens generated from aberrant over-expression, mutations and/or epigenetic alterations. Humoral immunity utilizes antibodies and immune-effector cells as well as molecular immune complexes involving the complement system to mediate the killing of dysregulated cancer cells. We refer to these anti-cancer mechanisms as Humoral Immuno-Oncology (HIO). Suppression of HIO is mediated by tumor-produced proteins called HIO factors. One such factor is CA125, which was previously shown to bind IgG-type antibodies and inhibit their antibody dependent (ADCC) and complement dependent (CDC) cellular cytotoxic activities. Using a combination of experimental screening and literature searches, we screened a number of proteins that have been produced by tumors and associated with a variety of cancer indications to determine if they could impact HIO. Herein, we describe the initial characterization of soluble ICAM-1 (sICAM-1), a tumor antigen capable of binding IgG-type antibodies that inhibits their immune-effector activity. <h3>Methods</h3> Deletion and site-directed mutatgenesis of the heavy constant domain of IgG1 was performed and constructs expressed as GST fusions in 293F cells. Recombinant proteins were then used in direct binding and competition ELISA formats to determine amino acid residues essential for binding of HIO-3. Constant region mutants that lost HIO-3 binding were then generated to whole IgG constructs for in vitro characterization of HIO-3 resistance. <h3>Results</h3> Amino acid substitutions in this domain were able to abrogate sICAM-1 binding and overcome ADCC suppression. <h3>Conclusions</h3> These findings highlight yet another mechanism by which tumors can suppress the host’s immune system for survival and offers new concepts for developing antibody-based therapies that can aid in the treatment of various cancer indications. Moreover, the findings here offer clinical design opportunities to improve upon existing approved immune-mediated therapies for which this factor is present.
Testing Results of the Prototype Beam Absorber for the PXIE MEBT (2014)

One of the goals of the PXIE program at Fermilab is to demonstrate the capability to form an arbitrary bunch pattern from an initially CW 162.5 MHz H⁻ bunch train coming out of an RFQ. The bunch-by-bunch selection will take place in the 2.1 MeV Medium Energy Beam Transport (MEBT) by directing the undesired bunches onto an absorber that needs to withstand a beam power of up to 21 kW, focused onto a spot with a ~2 mm rms radius. A prototype of the absorber was manufactured from molybdenum alloy TZM, and tested with an electron beam up to the peak surface power density required for PXIE, 17W/mm2. Temperatures and flow parameters were measured and compared to analysis. This paper describes the absorber prototype and key testing results.
Compressive Optical MONTAGE Photography Initiative: Noise and Error Analysis (2005)

Image resolution is usually considered to be proportional to the focal plane sampling rate. However, as a result of Papoulis’s generalized sampling theory [1], it is possible to reconstruct bandlimited images from sub-Nyquist sampled data provided multiple channels of such data are measured, with each set suitably transformed to permit the computation of the original image. The COMP-I program uses focal plane coding to set sub-band sampling characteristics. Analysis and simulation of this approach to errors and noise is presented.
380-pJ-threshold optical parametric generator in periodically poled lithium niobate waveguides (1998)

We demonstrate single-pass optical parametric generation (OPG) with a 380 pJ threshold using periodically poled lithium niobate (PPLN) waveguides pumped by a frequency-doubled diode-pumped erbium doped fiber laser.
Novel Converter Concept for Bearingless Slice Motor Systems (2006)

The general trend towards smaller and more economical designs has also reached bearingless slice motor (BSM) systems. Up to now, full-bridge converters have been used in order to independently control the phases of the active magnetic bearing and the drive system. In this paper, a simplified topology based on three half-bridges is proposed to replace two conventional full-bridges. With this, the number of required power semiconductors is reduced by 25%. The three half-bridges can be advantageously realized by one integrated IGBT module, thus achieving a reduction of the total converter volume by 43% as compared to a discrete full-bridge solution. The principle of operation is explained and analytical expressions for the calculation of the current stresses on the power components and DC-link capacitors are provided as a basis for a design of the system. Finally, the performance of the system is shown for a 600W prototype of the topology
A Simple Method for Synthesis of Methylene Dioximes Using Poly(ethylene glycol)‐400 as a Phase Transfer Catalyst (2004)

Abstract A simple method for synthesis of methylene dioximes by reaction of ketoximes with dichloromethane in the presence of aqueous sodium hydroxide solution using poly (ethylene glycol)‐400 (PEG‐400) as a phase transfer catalyst is described.
ChemInform Abstract: SYNTHETIC STUDIES TOWARD MITOMYCINS. 2. TOTAL SYNTHESIS OF DL‐PORFIROMYCIN (1978)

Abstract Die Synthese der Titelverbindung (IX) erfolgt ausgehend vom Nitril (Ia) über die Stufen (Ib) (3 Schritte) (IIa), (IIb) (3 Schritte), (IIIa)/(IIIb) (getrenntes Gemisch), (IV), (V), (VI), (VII) (die Überführung von (VI) in (VII) erfolgt nach bekanntem Verfahren), (VIIIa) und (VIIIb) (2 Schritte).
Characteristics of the gain and signal-to-noise ratio of a distributed erbium-doped fiber amplifier (1992)

The effects of stimulated Raman scattering (SRS) on the gain and signal-to-noise ratio (SNR) of the DEDFA with 100-km fiber length and with bidirectional pumps are numerically studied. It is found that the gain and SNR are significantly enhanced by the SRS with practical parameters. For 1.55- mu m signal and 10- mu W initial signal power, there are 8.8-dB gain enhancement and 3.3-dB SNR enhancement for 1.48- mu m pump wavelength and 75-mW initial pump power. The characteristics of the gain and SNR enhancements due to SRS are studied for different signal wavelength, signal powers, pump wavelengths, pump powers, and effective fiber cross sections. The results show that the gain and SNR are decreased by SRS only for the unpractical high pump power and/or small effective fiber cross section.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Survival Function of the FADD-CASPASE-8-cFLIPL Complex (2012)

Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, FADD, required for caspase-8 activation, and cFLIPL, a caspase-8-like protein that lacks a catalytic site and blocks caspase-8-mediated apoptosis, are each essential for embryonic development. Animals deficient in any of these genes present with E10.5 embryonic lethality. Recent studies have shown that development in caspase-8-deficient mice is rescued by ablation of RIPK3, a kinase that promotes a form of programmed, necrotic cell death. Here, we show that FADD, RIPK3 double-knockout mice develop normally but that the lethal effects of cFLIP deletion are not rescued by RIPK3 deficiency. Remarkably, in mice lacking FADD, cFLIP, and RIPK3, embryonic development is normal. This can be explained by the convergence of two cell processes: the enzymatic activity of the FADD-caspase-8-cFLIPL complex blocks RIPK3-dependent signaling (including necrosis), whereas cFLIPL blocks RIPK3-independent apoptosis promoted by the FADD-caspase-8 complex.
Validation of genome-wide polygenic risk scores for coronary artery disease in French Canadians (2019)

Abstract Coronary artery disease (CAD) represents one of the leading causes of morbidity and mortality worldwide. Given the healthcare risks and societal impacts associated with CAD, their clinical management would benefit from improved prevention and prediction tools. Polygenic risk scores (PRS) based on an individual’s genome sequence are emerging as potentially powerful biomarkers to predict the risk to develop CAD. Two recently derived genome-wide PRS have shown high specificity and sensitivity to identify CAD cases in European-ancestry participants from the UK Biobank. However, validation of the PRS predictive power and transferability in other populations is now required to support their clinical utility. We calculated both PRS (GPS CAD and metaGRS CAD ) in French-Canadian individuals from three cohorts totaling 3639 prevalent CAD cases and 7382 controls, and tested their power to predict prevalent, incident and recurrent CAD. We also estimated the impact of the founder French-Canadian familial hypercholesterolemia deletion ( LDLR delta &gt; 15kb deletion) on CAD risk in one of these cohorts and used this estimate to calibrate the impact of the PRS. Our results confirm the ability of both PRS to predict prevalent CAD comparable to the original reports (area under the curve (AUC) = 0.72-0.84). Furthermore, the PRS identified about 6-7% of individuals at CAD risk similar to carriers of the LDLR delta &gt; 15kb mutation, consistent with previous estimates. However, the PRS did not perform as well in predicting incident (AUC= 0.56 - 0.60) or recurrent (AUC= 0.56 - 0.60) CAD. This result suggests that additional work is warranted to better understand how ascertainment biases and study design impact PRS for CAD. Collectively, our results confirm that novel, genome-wide PRS are able to predict CAD in French-Canadians; with further improvements, this is likely to pave the way towards more targeted strategies to predict and prevent CAD-related adverse events.
Radiation pneumonitis imaged with indium-111-pentetreotide. (1996)

Indium-111-pentetreotide can detect radiation pneumonitis and may have a role in both the differential diagnosis of patients who have complaints after radiotherapy, and when supported by quantification in the monitoring of response to steroid therapy.
FASE (2016)

Dynamic information-flow enforcement systems automatically protect applications against confidentiality and integrity threats. Unfortunately, existing solutions cause undesirable side effects, if not crashes, due to unconstrained modification of run-time values (e.g. anonymizing sensitive identifiers even when these are used for authentication).
ChemInform Abstract: Asymmetric Synthesis of (‐)‐Denticulatins A and B via Group‐Selective Aldolization of a meso Dialdehyde with a Chiral N‐Propionylsultam. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The poetry of Liberto Cruz: art and communication (2015)

Neste artigo procuraremos mostrar como ĂŠ que se estabelece na obra de Liberto Cruz um compromisso entre o poema enquanto texto livre de quaisquer imposiĂ§&otilde;es ideolĂłgicas e enquanto aĂ§&atilde;o social e polĂ­tica, entre a experi&ecirc;ncia interior e pessoal e o comprometimento na histĂłria do paĂ­s, entre a auto-sufici&ecirc;ncia do poema e a sua ligaĂ§&atilde;o ao mundo, entre a comunicaĂ§&atilde;o e a elevaĂ§&atilde;o, entre o alargamento imagĂŠtico e semĂ˘ntico e a comunicaĂ§&atilde;o de sentimentos, emoĂ§&otilde;es e ideias, entre o eu textual e o eu biogrĂĄfico.
High-finesse resonant-cavity photodetectors with an adjustable resonance frequency (1996)

High speeds, high external quantum efficiencies, narrow spectral linewidths, and convenience in coupling make resonant-cavity photodetectors (RECAP's) good candidates for telecommunication applications. In this paper, we present analytical expressions for the design of RECAP's with narrow spectral linewidths and high quantum efficiencies. We also present experimental results on a RECAP having an operating wavelength /spl lambda//sub 0//spl ap/1.3 /spl mu/m with a very narrow spectral response. The absorption takes place in a thin In/sub 0.53/Ga/sub 0.47/As layer placed in an InP cavity. The InP p-i-n structure was wafer bonded to a high-reflectivity GaAs/AlAs quarter-wavelength Bragg reflector. The top mirror consisted of three pairs of a ZnSe/CaF/sub 2/ quarter-wavelength stack (QWS). A spectral linewidth of 1.8 nm was obtained with an external quantum efficiency of 48%. We also demonstrate that the spectral response can be tailored by etching the top layer of the microcavity. The results are found to agree well with those obtained from analytical expressions derived on the assumption of linear-phase Bragg reflectors as well as detailed simulations performed using the transfer matrix method.
Recursive estimation in the presence of uniformly distributed measurement noise (1981)

This note examines a discrete-time linear dynamic system, absent of disturbance noise, for which all uncertainties are uniformly distributed. With these assumptions, we prove that the posterior probability distribution of the state variable is also uniformly distributed. This result is exploited to construct a simple minimum error variance state estimation algorithm for the one-dimensional problem. Finally, we show how this algorithm relates to both the problem of estimation using a set-theoretic description of uncertainty, and estimation using order statistics.
Immunotherapy combining NK and T cell activation with IL-15 super agonist (N-803), off-the-shelf high-affinity CD16 NK (haNK) or PDL1 targeted haNK and checkpoint inhibitor in relapsed/refractory advanced pancreatic cancer. (2020)

e15015 Background: Pancreatic cancer is the third leading cause of cancer-related deaths in the US. Patients who relapse after first/second-line chemotherapy have a 2 month median survival. In this relapsed population, there is no approved therapy. Effective response requires a coordinated approach that orchestrates both the innate and adaptive immune system. We hypothesize that by orchestrating the activation of the entire immune system, we could accomplish immunogenic cell death with clinical benefit. We describe a first-in-human novel combination immunotherapy protocol of chemoradiation, cytokine-induced NK and T cell activation, checkpoint inhibition, and off-the-shelf allogeneic high-affinity NK cell infusion (haNK). We report the first complete response (CR) to an NK-based immunotherapy combination in pancreatic cancer. Methods: QUILT-3.039/3.060/3.070/3.080 enrolled a total of 12 patients (8M/4F), median age 57.5 (35-74), ECOG 0-2) with advanced pancreatic with progressive disease after prior chemotherapy. There were differences in the dose and schedule of agents used across the various protocols. Common elements were: 1. Reduced dose metronomic chemotherapy (combinations of aldoxorubicin, gemcitabine, abraxane, oxaliplatin, 5FU, and cyclophosphamide) 2. SBRT, 3. Avelumab, 4. N803 (IgG1 Fc-engineered IL-15-fusion protein), 5. Allogeneic haNK cells. This experience led to a SPIND substituting allogeneic haNK cells with allogeneic haNK cells targeted against PDL-1. All treatment was in an outpatient setting. A median of 6 cycles of haNK cells (2-15) were delivered for a cumulative median dose of 29.0 x 10 9 cells per patient (8.0-56.0 x 10 9 ). Results: In 12 patients across 4 studies, a median of 6 (2,15) cycles of treatment were delivered, resulting in median PFS of 6.6 mo (3.3-12.4), OS 8.1 mo (5.0-27.0). 11/12 (92%) patients experienced stable disease (SD) for &gt; 8 weeks. 11/12 (92%) also experience at least 1 grade 3 AE: neutropenia (92%), anemia (50%), febrile neutropenia (17%), diarrhea (8%), hyperglycemia (25%), hyponatremia (17%), and elevated alkaline phosphatase (8%). The SPIND patient (79 yo M, ECOG 1) received 7 cycles and achieved a CR by PET with 5 months follow-up to date. No grade 4 AEs were seen. No severe immune related AE’s were seen. Conclusions: Orchestrated immunomodulatory outpatient combination treatment is feasible and results in clinical benefit and CR in selected patients with acceptable toxicity.
Endoscopic-Assisted Microvascular Decompression (2018)

Diseases of ephaptic transmission are commonly caused by vascular compression of cranial nerves. The advent of microvascular decompression has allowed for surgical intervention for this patient population. This chapter highlights the technique of endoscopic-assisted microvascular decompression for trigeminal neuralgia and hemifacial spasm. Endoscopy and keyhole techniques have resulted in a minimally invasive and effective treatment of symptoms for patients with neuralgia.
Cross-Stream Migration of Flexible Molecules in a Nanochannel (2006)

Molecular dynamics simulations are used to examine the cross-stream chain migration phenomenon in dilute polymer solutions that are flowing in nanochannels. In particular, both uniform planar shear (Couette) and pressure driven (Poiseuille) flows of a dilute polymer solution are studied using a bead-spring representation of polymer chains and a coarse grained model for the solvent. Our results show that three mechanisms govern the migration of deformable molecules in a nanochannel: (1) chain-wall hydrodynamic interactions, (2) thermal diffusion, and (3) gradient in chain mobility. These results are discussed in the context of recent experimental, numerical and theoretical work.
ChemInform Abstract: A Facile and Expedient Route to Allyl and Propargyl Amines Using N‐(α‐Benzotriazolylalkyl)amines as Stabilized Iminium Salts. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In Vivo Natural Killer Cell Depletion during Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys (2008)

The contribution of natural killer (NK) cells to the immune containment of human immunodeficiency virus infection remains undefined. To directly assess the role of NK cells in an AIDS animal model, we depleted rhesus monkeys of >88% of CD3(-) CD16(+) CD159a(+) NK cells at the time of primary simian immunodeficiency virus (SIV) infection by using anti-CD16 antibody. During the first 11 days following SIV inoculation, when NK cell depletion was most profound, a trend toward higher levels of SIV replication was noted in NK cell-depleted monkeys compared to those in control monkeys. However, this treatment did not result in significant changes in the overall levels or kinetics of plasma viral RNA or affect the SIV-induced central memory CD4(+) T-lymphocyte loss. These findings are consistent with a limited role for cytotoxic CD16(+) NK cells in the control of primary SIV viremia.
Efficient continuous-spectrum analysis based on sweep-filtering technics (1989)

The described spectral-analysis principle based on sweep-filtering is cheap to realize and it is absolutely usable. So it is possible to perform usable continuous-spectrum analysis effectively, if the main requirement is met (i.e. a rather large sweeptime T/sub o/ is allowed, and the signal is stationary during every sweep). A system has been built and tested. It consists of: 6 parallel analysis-systems based on switched capacitor filters. 5 analog delay registers/bucket brigade delay-lines. 1 'fourfold'-frequency-transformation circuit based on 2 BBD-delay-lines and analog switches. 1 analog addition circuit, analog antialiasing filters 1 control-logic/clock-generator circuit. The system performs the described spectral-estimation including spectral averaging and 'fourfold'-frequency transformation. It has been tested in different connections with good results. >
Molecular targets of immunosuppressive pyrazole derivatives: From TRPC channels to mTOR (2008)

Pyrazole‐containing immunosuppressive compounds exemplified in the literature by BTP2 have been identified in several labs. Published studies demonstrated that BTP2 can inhibit both receptor and store‐operated Ca2+‐influx in both native cells and cells transfected with members of the TRPC ion channel family. Here, we show the results of pull‐down studies performed with a biotinylated BTP2 analog attached to avidin beads. Lysates were prepared from Jurkat cells and HEK293 stably transfected with TRPC6, TRPC3, or TRPC5. Binding proteins were identified by mass spec, Western blots, or both. Identified binding proteins included TRPC3, TRPC5, TRPC6, STIM1, eIF3, PKCα, FKBP52, FKBP12, mTOR, calcineurin, and p70 S6 kinase. Many of the proteins in this group are known to complex with or regulate other members so it is not clear which proteins have actual binding interactions with the inhibitor probe. A potential link is the presence of FKBP proteins which are involved in regulation of both the TRPC and mTOR pathways. We observed direct probe binding to recombinant FKBP12 and an ability of PKC inhibitors to reverse Ca2+‐influx inhibition by BTP2 in HEK293‐TRPC6 cells. PKC phosphorylation of TPRC molecules inhibits their activity and activates TRPM4 activity. We propose that BTP2‐like compounds inhibit dephosphophorylation of TRPC to help impart their immunosuppressive effects.