gebhart/patrepeval huggingface dataset:
Reply to Comment on “Hydrophobic Forces in the Foam Films Stabilized by Sodium Dodecyl Sulfate:  Effect of Electrolyte” and Subsequent Criticism (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommentNEXTReply to Comment on "Hydrophobic Forces in the Foam Films Stabilized by Sodium Dodecyl Sulfate: Effect of Electrolyte" and Subsequent CriticismPeter A. Kralchevsky, Krassimir D. Danov, and Jana K. AngarskaView Author Information Laboratory of Chemical Physics & Engineering, Faculty of Chemistry, University of Sofia, 1164 Sofia, Bulgaria, and Department of General Chemistry, University of Shumen, 9712 Shumen, Bulgaria Cite this: Langmuir 2008, 24, 6, 2953Publication Date (Web):February 14, 2008Publication History Received13 November 2007Published online14 February 2008Published inissue 1 March 2008https://pubs.acs.org/doi/10.1021/la7035345https://doi.org/10.1021/la7035345article-commentaryACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views312Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (10 KB) Get e-AlertscloseSUBJECTS:Foams,Hydrophobicity,Stability,Surfactants,Thickness Get e-Alerts
Lack of hydroxyurea‐associated mutagenesis in pediatric sickle cell disease patients (2023)

Hydroxyurea is approved for treating children and adults with sickle cell anemia (SCA). Despite its proven efficacy, concerns remain about its mutagenic and carcinogenic potential that hamper its widespread use. Cell culture- and animal-based investigations indicate that hydroxyurea's genotoxic effects are due to indirect clastogenicity in select cell types when high dose and time thresholds are exceeded (reviewed by Ware & Dertinger, 2021). The current study extends these preclinical observations to pediatric patients receiving hydroxyurea for treatment of SCA. First, proof-of-principle experiments with testicular cancer patients exposed to a cisplatin-based regimen validated the ability of flow cytometric blood-based micronucleated reticulocyte (MN-RET) and PIG-A mutant reticulocyte (MUT RET) assays to detect clastogenicity and gene mutations, respectively. Second, these biomarkers were measured in a cross-sectional study with 26 SCA patients receiving hydroxyurea and 13 SCA patients without exposure. Finally, a prospective study was conducted with 10 SCA patients using pretreatment blood samples and after 6 or 12 months of therapy. Cancer patients exposed to cisplatin exhibited increased MN-RET within days of exposure, while the MUT RET endpoint required more time to reach maximal levels. In SCA patients, hydroxyurea induced MN-RET in both the cross-sectional and prospective studies. However, no evidence of PIG-A gene mutation was found in hydroxyurea-treated children, despite the fact that the two assays use the same rapidly-dividing, highly-exposed cell type. Collectively, these results reinforce the complementary nature of MN-RET and MUT RET biomarkers, and indicate that hydroxyurea can be clastogenic but was not mutagenic in young patients with SCA.
Solution Properties of a CO2-Soluble Fluoropolymer via Small Angle Neutron Scattering (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolution Properties of a CO2-Soluble Fluoropolymer via Small Angle Neutron ScatteringJ. B. McClain, D. Londono, J. R. Combes, T. J. Romack, D. A. Canelas, D. E. Betts, G. D. Wignall, E. T. Samulski, and J. M. DeSimoneView Author Information Venable and Kenan Laboratories Department of Chemistry CB#3290 University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27599-3290 Oak Ridge National Laboratories P.O. Box 2008, Oak Ridge, Tennessee 37831-6393 Cite this: J. Am. Chem. Soc. 1996, 118, 4, 917–918Publication Date (Web):January 31, 1996Publication History Received11 August 1995Published online31 January 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja952750shttps://doi.org/10.1021/ja952750srapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views507Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Neutron scattering,Polymer solutions,Polymers,Scattering,Solvents Get e-Alerts
Effect of Al2O3 capping layer on suppression of interfacial SiO2 growth in HfO2/ultrathin SiO2/Si(001) structure (2003)

We investigated the effect a 1.2-nm-thick Al2O3 capping layer had on suppressing interfacial Si oxidation in a 2.6-nm-HfO2/0.35-nm-SiO2/Si(001) structure during postdeposition annealing in an oxygen ambient. An incubation period (IP) was initially observed during which the HfO2/Si interface exhibited remarkable stability without any interfacial SiO2 growth. This was then followed by very slow interface oxidation. Our detailed study suggested that low oxidant diffusion through the capping layer determined the effective IP. Furthermore, HfO2/Si interface oxidation, which proceeded through a two-step process that was similar to an uncapped structure, was severely constrained by the limited availability of oxygen at the Al2O3/HfO2 interface.
Age-Dependence of Hypertensive (1983)

Increased sympathetic nervous activity may play an important role in the pathogenesis of essential hypertension. It is well-known that both dietary sodium intake and age influence plasma norepinephrine (P-NE). There are many reports on comparative studies of P-NE in patients with essential hypertension and normotensive controls. However, there are few studies on changes in plasma catecholamines in both the aging and salt intake states. The present study was undertaken to evaluate the effect of age on sympathetic nervous activity in patients with essential hypertension and normal controls under low (UNa V 29 +/- 3 mEq/day), regular (UNa V 133 +/- 8 mEq/day) and high (UNa V 324 +/- 12 mEq/day) sodium regimens. The catecholamine levels were analyzed by THI methods after HPLC separation. Twenty-four hour urinary norepinephrine, epinephrine and electrolyte (Na+, K+) excretion on day 5 of each regimen was also determined. On day 6 morning, supine and upright P-NE, plasma epinephrine and plasma renin activity were determined after blood pressure and pulse rate measurement. Subjects were separated according to age as follows: young (less than 40 y.o.), middle-aged (40 approximately 60 y.o.) and old (greater than 60 y.o.). P-NE in hypertensives was significantly higher than in normals under any three sodium intakes. There was a significantly positive correlation between age and P-NE, but only in normal controls under three sodium intakes and not in hypertensive patients under any three sodium regimens. In the young group of hypertensive patients, P-NE was significantly higher than that of normal controls. These results suggest that the increased sympathetic nervous activity plays an important role in the pathogenesis and maintenance of essential hypertension, and this is particularly obvious in young patients.
Microstructure and micromechanism maps to optimise useful deformation processing conditions in magnesium alloy (2011)

The present investigation examines the use of microstructure and micromechanism maps to develop a systematic understanding of the various microstructures that evolve in pure Mg and Mg–Al–Ce alloys during uniaxial compression deformation over a range of strain rates and temperatures. These maps further refine the safe deformation regimes that are predicted by dynamic materials modelling maps (or process modelling), which are based on efficiency of power dissipation for microstructure evolution η and the instability parameter Σ([Formula: see text] ). Operating mechanisms such as dynamic recrystallisation, cracking, twinning and grain coarsening are identified through careful microstructural analysis and mapped as a matrix at appropriate locations on a two-dimensional strain rate–temperature map. The study demonstrates that while conventional process maps delineate safe and unsafe working regimes based on power dissipation, it is the use of the microstructure and micromechanism maps in conjunction with the process maps that provide a more accurate and comprehensive picture of the processing window, which should be used for producing materials with certain defined end use. The process maps developed have been validated with a limited number of extrusion trials on pure Mg and Mg–Al–Ce alloys.
Moving Object Segmentation using Scene Understanding (2006)

We present a novel approach to moving object detection in video taken from a translating, rotating and zooming sensor, with a focus on detecting very small objects in as few frames as possible. The primary innovation is to incorporate automatically computed scene understanding of the video directly into the motion segmentation process. Scene understanding provides spatial and semantic context that is used to improve frame-to-frame homography computation, as well as direct reduction of false alarms. The method can be applied to virtually any motion segmentation algorithm, and we explore its utility for three: frame differencing, tensor voting, and generalized PCA. The approach is especially effective on sequences with large scene depth and much parallax, as often occurs when the sensor is close to the scene. In one difficult sequence, our results show an 8-fold reduction of false positives on average, with essentially no impact on the true positive rate. We also show how scene understanding can be used to increase the accuracy of frame-to-frame homography estimates.
IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease (2003)

BCR-ABL expression led to a dramatic up-regulation of the IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor receptor beta common (IL-3Rbetac) and IL-3 receptor beta (IL-3Rbeta) chains in murine embryonic stem cell-derived hematopoietic cells coincident with an expansion of multipotent progenitors and myeloid elements. This up-regulation required BCR-ABL tyrosine kinase activity and led to IL-3Rbetac/beta chain tyrosine phosphorylation in the absence of detectable IL-3 production. These results suggested that cytokine-independent IL-3 receptor activation could be a dominant signaling component in BCR-ABL-induced leukemogenesis. To unambiguously define the significance of IL-3 receptor-dependent signaling in BCR-ABL-induced leukemogenesis, BCR-ABL-transduced bone marrow cells deficient in either IL-3Rbetac chain or both IL-3Rbetac/beta chain expression were examined for their ability in generating myeloproliferative disease (MPD). These BCR-ABL-expressing knockout cells were capable of generating MPD similar to control cells, demonstrating that IL-3 receptor activation is not essential for BCR-ABL-induced MPD. However, the IL-3Rbetac/beta chain could act as a cofactor in BCR-ABL-induced leukemogenesis by activation of its many known oncogenic signaling pathways.
Learning Connectivity and Higher-order Interactions in Radial Distribution Grids (2019)

To perform any meaningful optimization task, distribution grid operators need to know the topology of their grids. Although power grid topology identification and verification has been recently studied, discovering instantaneous interplay among subsets of buses, also known as higher-order interactions in recent literature, has not yet been addressed. The system operator can benefit from having this knowledge when re-configuring the grid in real time, to minimize power losses, balance loads, alleviate faults, or for scheduled maintenance. Establishing a connection between the celebrated exact distribution flow equations and the so-called self-driven graph Volterra model, this paper puts forth a nonlinear topology identification algorithm, that is able to reveal both the edge connections as well as their higher-order interactions. Preliminary numerical tests using real data on a 47-bus distribution grid showcase the merits of the proposed scheme relative to existing alternatives.
Synthesis of a polymer chain having conjugated unsaturated bonds by dehydrohalogenation of polyhalogen‐containing polymers (1964)

Abstract Polyvinyl chloride (I), polyvinylidene chloride (II) and further chlorinated products of polyvinyl chloride (III) can be completely dehydrohalogenated if appropriate conditions are chosen. The elementary analyses of the products fit the formula (CH) n . The infrared spectra and x‐ray diffraction patterns indicate that the structure of the products is similar to that of noncrystalline, trans ‐polyacetylene. The absorption band due to CHCH ( trans ) is observed for all products; for the products from (II) and (III), the band due to CC also appears. All products show paramagnetic properties. The highest value of specific resistivity is about 10 4 ohm‐cm.
A phase 1, open label, dose escalation study of MGD009, a humanized B7-H3 x CD3 DART protein, in combination with MGA012, an anti-PD-1 antibody, in patients with relapsed or refractory B7-H3-expressing tumors. (2018)

TPS2601 Background: T cells naturally undergo activation-induced upregulation of co-inhibitory pathways, which may limit the antitumor immune response. Blocking these inhibitory pathways may enhance the antitumor activity of CD3 bispecifics. MGD009 is a clinical stage B7-H3 x CD3 DART protein designed to redirect T cells to kill B7-H3 expressing tumor cells. B7-H3, a member of B7 family of immune regulators, is overexpressed in a variety of solid tumors and has limited expression in normal tissues. In preclinical studies, MGD009 causes T-cell infiltration, activation and expansion in the tumors. It upregulates PD-1 on T cells and PD-L1 on tumor cells and immune cells in vitro. Preliminary observations in patients enrolled in the ongoing phase 1 dose escalation trial with MGD009 alone indicate evidence of PD-1 up-regulation on both peripheral CD4 and CD8 T-cells. MGA012 is an anti-PD-1 antibody under investigation in an ongoing Phase 1 clinical trial and has shown clinical responses. In vitro and in vivo studies have shown enhanced antitumor activity with the combination of MGD009 and MGA012 beyond that achieved with MGD009 alone. A combination approach that blocks checkpoint inhibition of T cells with MGA012, while recruiting cytotoxic and helper T cells to B7-H3-expressing tumors with MGD009, may show anti-tumor activity in a variety of tumors. Methods: This is a Phase 1, open-label, dose escalation, and cohort expansion study designed to characterize the safety, tolerability, PK, pharmacodynamics, immunogenicity, and preliminary antitumor activity of MGD009 in combination with MGA012, both administered by IV infusion. Patients with B7-H3-expressing unresectable, locally advanced or metastatic solid tumors of any histology will be enrolled in the Dose Escalation Phase. Prior checkpoint inhibitor therapy is allowed. Dose escalation uses a 3+3+3 design, with patients treated every 2 weeks with escalating doses of IV MGD009 (starting dose 3µg/kg) and MGA012 at a dose of 3mg/kg in all cohorts. Cohort expansions will be limited to 6 tumor types (N = 20/cohort) treated at the maximum tolerated dose of the combination. Clinical trial information: NCT03406949.
Cost-efficient electromagnetic-simulation-driven antenna design using co-Kriging (2012)

A technique for design optimisation of antennas is presented. The approach exploits coarse-discretisation electromagnetic (EM) simulations of the antenna of interest that are used to create its fast initial model (a surrogate) through Kriging. During the design process, predictions obtained by optimising the surrogate are verified using high-fidelity EM simulations, and these high-fidelity data are used to enhance the surrogate using co-Kriging interpolation that accommodates all EM simulation data into one surrogate model. The co-Kriging-based optimisation algorithm is simple and it is capable of yielding a satisfactory design at a low-cost equivalent to a few high-fidelity EM simulations of the antenna under design. To the best of author&apos;s knowledge, this is a first application of co-Kriging to antenna design. The proposed approach is demonstrated using several antenna design cases and compared with other techniques including pattern search and space mapping.
ChemInform Abstract: Tropane‐Based Alkaloids as Muscarinic Antagonists for the Treatment of Asthma, Obstructive Pulmonary Disease, and Motion Sickness (2013)

Abstract Review: 64 refs.
Electrostatic and hydrophobic effects in affinity chromatography (1975)

Abstract A semi–quantitative theory is developed to explain the nonspecific binding of proteins to substituted affinity chromatography supports due to electrostatic and hydrophobic interactions. The equilibrium constant for the absorption of an enzyme to a solid support, and the rate of desorption of the enzyme are studied as functions of ionic strength. Experimental measurements were taken of the adsorption equilibrium constant and rate of desorption of E. coli β–galactosidase on Sepharose 4B substituted with 3, 3,‐diaminodipropylamine in batch systems. It was found that the enzyme adsorption exhibits a hysteresis effect as the ionic strength is increased and then decreased. Furthermore, the adsorption of theenzyme becomes more reversible at the lower ionic strengths, while at the higher ionic strengths it is essentially irreversible. Using the measured equilibrium constants, and knowing the region of ionic strength where the adsorption becomes reversible, we were able to predict the desorption of enzyme in a continuous stirred tank as a function of time when a decreasing linear gradient of ionic strength was introduced into a slurry. It was found that the presence of another protein, hemoglobin, does not affect these results, and therefore can be separated from the enzyme.
Identification of new flaviviruses in the Kokobera virus complex (2004)

Novel flavivirus isolates from mosquitoes collected in northern Australia were analysed by partial genomic sequencing, monoclonal antibody-binding assays and polyclonal cross-neutralization tests. Two isolates were found to be antigenically distinct from, but related to, viruses of the Kokobera virus complex, which currently contains Kokobera (KOKV) and Stratford (STRV) viruses. Nucleotide sequence comparison of two separate regions of the genome revealed that an isolate from Saibai Island in the Torres Strait in 2000 (TS5273) was related closely to KOKV and STRV, with 74-80 and 75-76 % nucleotide similarity, respectively. An isolate from mainland Cape York in 1998 (CY1014) was found to be more divergent from KOKV and STRV, with <70 % nucleotide sequence similarity to either virus. It is proposed that isolate TS5273 represents a new subtype of KOKV and that CY1014 be classified as a novel species within the Kokobera virus complex of flaviviruses, named New Mapoon virus.
Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties (2008)

The results may explain the efficacy of lysoPC therapy during periods of elevated inflammatory activity and further highlight the utility uncompetitive enzyme inhibitors. In this case, the inhibitor is a product of the enzyme reaction, and therefore represents an example of activity-driven feedback inhibition.
GaN-Based Stress-Induced Bandgap Widening with Various Arrangements of Patterned Sapphire Substrates (2016)

By varying the arrangements of patterned sapphire substrates, the stress-induced bandgap widening of GaN-based epitaxial layers can be acquired. Photoluminescence and Raman results demonstrate a linear relationship of blue-shift with the increase of residual stress.
Enhanced Well Productivity Potential from a New High-Density Reservoir Drilling Fluid (2001)

A new reservoir drilling fluid system utilizes a nonbiopolymer, acid- or enzyme-solubl e polymer that serves both as viscosifier and fluid-loss additive when combined with activated magnesium oxide and a divalent-catio nbased brine. The fluid shows a unique shear-thinning rheological profile featuring relatively low, high-shear-rate viscosity along with relatively high, low-shear-rate viscosity. As a result, effective hole cleaning is provided without generating excessive high-shear-rate viscosities that lead to disproportionate equivalent circulating densities. The new fluid system is based on the higher density, divalent-cationcontaining brines (utilizing CaCl2, CaBr2, CaCl 2 / CaBr2, ZnBr2 / CaBr2 and ZnBr2 / CaBr2 / CaCl2) in the 11.5 to 17.5 lb/gal density range. The total amount of the sized CaCO3 bridging particles is kept relatively low, 13 to 35 lb/bbl, so that thin, chemically removable filter cakes are produced. This bridging particle matrix size distribution is designed according to the ideal packing sequence for optimizing sealing and producing a minimally invading (well productivity enhancing) fluid.
Nanopatterning of multiferroic BiFeO3 using “soft” electron beam lithography (2006)

The authors report fabrication of multiferroic BiFeO3 (BFO) by the soft electron beam lithography technique. BiFeO3 nanopatterns with less than 100nm characteristic dimension are fabricated from its liquid-phase precursor on diverse substrates. The chemical constituents and phase purity are characterized by transmission electron microscopy. The ferroelectric behavior is confirmed by piezoresponse force microscopy. A saturation magnetization of about 10emu∕cm3 is observed, demonstrating the multiferroic characteristic of the BFO nanopatterns. Furthermore, the BFO nanolines pattened on SrTiO3 substrate exhibit a bamboolike structure, which can serve as an excellent model system for investigating the contribution of grain boundaries to the leakage current.