gebhart/patrepeval huggingface dataset:
Prediction-error filters for signal and noise separation within ultrasound recordings (2019)

Ultrasonic image quality can be compromised by several mechanisms such as reverberation, off-axis scattering, and sound-speed inhomogeneities. These mechanisms can cause a loss of coherence of signals across the aperture and clutter in a B-mode image potentially leading to inadequate visualization and misdiagnosis. We develop a processing technique based on prediction-error filters (PEFs) for isolating tissue signal and several types of noise in the individual channel data of ultrasound scans. We first estimate a set of PEFs that allows for prediction of the 2-D spectra of signal and noise in the channel data domain and then use these filters to separate the signal and noise components within the recorded echoes. We use the Van Cittert-Zernike theorem as a priori knowledge of the signal spectrum to develop the signal-PEF, while the noise-PEFs are estimated directly from the channel data. We apply our PEFs to channel data from fullwave simulations of abdominal scans and to data acquired on a lesion phantom through a layer of bovine tissue. The proposed technique successfully separates signal from noise and improves lag-one coherence of the speckle signal from 0.47 to 0.97.
On the Nature of the Binding Sites for Cationic Surfactants on Silica:  Studies Using Electron Paramagnetic Resonance Spectroscopy (1999)

Adsorption of the spin-probe 4-[N,N-dimethyl-N-(n-hexadecyl)ammonium]-2,2,6,6-tetramethylpiperidinyl-N‘-oxyl bromide (HTAB*) onto silica in aqueous dispersions has been studied using electron paramagnetic resonance (EPR) spectroscopy. The spin probe has been found to partition between three environments, the aqueous solution, the surface of the silica, and aggregates on the surface. The partitioning between these three environments is reported as a function of available silica surface, pH, and added hexadecyltrimethylammonium bromide (HTAB). At low pH and large silica surface area the spin probe appears to adsorb flat onto hydrophobic areas of the silica surface. At high pH and small surface area the spin probe forms surfactant aggregates.
Distributed Caching for Enhancing Communications Efficiency (2017)

This chapter investigates a fog network architecture in order to provide unprecedented bandwidth spatial reuse gains. The architecture consists of two caching methods. In the first method, termed fem-tocaching, small dedicated “helper nodes” were used to cache popular files and serve requests from wireless users by enabling localized wireless communication, hence increasing the spectral efficiency. The chapter discusses the optimal uncoded and coded content placement, as well as the optimal content delivery in such systems. In the second method, termed user-caching, the devices pooled their caching resources so that different devices cache different files and then exchange them, when the occasion arises, through short-range, highly spectrally efficient, D2D communications. The chapter discusses the optimal physical layer delivery mechanisms in such systems, in order to maximize the spectral reuse. It also discusses “coded multicast” opportunities that can arise in such systems.
Reproducibility of swallow-induced cortical BOLD positive and negative fMRI activity (2012)

Functional MRI (fMRI) studies have demonstrated that a number of brain regions (cingulate, insula, prefrontal, and sensory/motor cortices) display blood oxygen level-dependent (BOLD) positive activity during swallow. Negative BOLD activations and reproducibility of these activations have not been systematically studied. The aim of our study was to investigate the reproducibility of swallow-related cortical positive and negative BOLD activity across different fMRI sessions. We studied 16 healthy volunteers utilizing an fMRI event-related analysis. Individual analysis using a general linear model was used to remove undesirable signal changes correlated with motion, white matter, and cerebrospinal fluid. The group analysis used a mixed-effects multilevel model to identify active cortical regions. The volume and magnitude of a BOLD signal within each cluster was compared between the two study sessions. All subjects showed significant clustered BOLD activity within the known areas of cortical swallowing network across both sessions. The cross-correlation coefficient of percent fMRI signal change and the number of activated voxels across both positive and negative BOLD networks were similar between the two studies (r ≥ 0.87, P < 0.0001). Swallow-associated negative BOLD activity was comparable to the well-defined "default-mode" network, and positive BOLD activity had noticeable overlap with the previously described "task-positive" network. Swallow activates two parallel cortical networks. These include a positive and a negative BOLD network, respectively, correlated and anticorrelated with swallow stimulus. Group cortical activity maps, as well as extent and amplitude of activity induced by volitional swallowing in the cortical swallowing network, are reproducible between study sessions.
Consistent Predictive Simulation of SRAM-Cell Performance Degradation Including Both MOSFET Fabrication Variation and Aging (2018)

We have developed a methodology to simulate circuit aging including the device fabrication variation with less simulation effort. As an example a 6T SRAM cell has been investigated. It is demonstrated that the variability range of the circuit performance is further enhanced due to the long-term device aging. Among the device parameters, the impurity concentration variation plays a particularly important role for the circuit performance variation. However, most sensitive for the aging degradation is the channel-length variation, because it increases the aging effect drastically. Further, the individual aging of each MOSFET is strongly dependent on the actual stress during circuit operation.
Validated Computational Model to Compute Re-apposition Pressures for Treating Type-B Aortic Dissections (2018)

The use of endovascular treatment in the thoracic aorta has revolutionized the clinical approach for treating Stanford type B aortic dissection. The endograft procedure is a minimally invasive alternative to traditional surgery for the management of complicated type-B patients. The endograft is first deployed to exclude the proximal entry tear to redirect blood flow toward the true lumen and then a stent graft is used to push the intimal flap against the false lumen (FL) wall such that the aorta is reconstituted by sealing the FL. Although endovascular treatment has reduced the mortality rate in patients compared to those undergoing surgical repair, more than 30% of patients who were initially successfully treated require a new endovascular or surgical intervention in the aortic segments distal to the endograft. One reason for failure of the repair is persistent FL perfusion from distal entry tears. This creates a patent FL channel which can be associated with FL growth. Thus, it is necessary to develop stents that can promote full re-apposition of the flap leading to complete closure of the FL. In the current study, we determine the radial pressures required to re-appose the mid and distal ends of a dissected porcine thoracic aorta using a balloon catheter under static inflation pressure. The same analysis is simulated using finite element analysis (FEA) models by incorporating the hyperelastic properties of porcine aortic tissues. It is shown that the FEA models capture the change in the radial pressures required to re-appose the intimal flap as a function of pressure. The predictions from the simulation models match closely the results from the bench experiments. The use of validated computational models can support development of better stents by calculating the proper radial pressures required for complete re-apposition of the intimal flap.
Grid-Tied Multi-Port PV Battery System with ANFIS based Model Predictive Control (2022)

This paper proposes an Adaptive Neuro Fuzzy Interface System (ANFIS) based Model Predictive Control (MPC) technique for a multi-port PV Battery system. The paper analyses a multi-port DC microgrid system to combine renewable energy sources with storage while applying fast, adaptive controls. In this regard, a maximum power point tracking (MPPT) based on an adaptive Perturb and Observe (P&O) method is used to maximize PV solar power and regulate the DC to DC converters. The Battery Management System (BMS) is the main focus of the paper. An ANFIS MPC based BMS is developed to achieve high efficiency as well as reliability. On the other hand, a three-phase Fuzzy logic inverter control is implemented to interface the grid simultaneously with the load. Finally, a comparison of the proposed method is drawn with the Proportional Integral (PI) controller using the MATLAB/Simulink platform.
Supplemental Table 1 from First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors (2023)

&lt;p&gt;Serum concentration of intact sacituzumab govitecan and hRS7 IgG taken 30 min after injection for each of the 4 dose levels tested.&lt;/p&gt;
Molecular sled sequences are common in mammalian proteins (2016)

Recent work revealed a new class of molecular machines called molecular sleds, which are small basic molecules that bind and slide along DNA with the ability to carry cargo along DNA. Here, we performed biochemical and single-molecule flow stretching assays to investigate the basis of sliding activity in molecular sleds. In particular, we identified the functional core of pVIc, the first molecular sled characterized; peptide functional groups that control sliding activity; and propose a model for the sliding activity of molecular sleds. We also observed widespread DNA binding and sliding activity among basic polypeptide sequences that implicate mammalian nuclear localization sequences and many cell penetrating peptides as molecular sleds. These basic protein motifs exhibit weak but physiologically relevant sequence-nonspecific DNA affinity. Our findings indicate that many mammalian proteins contain molecular sled sequences and suggest the possibility that substantial undiscovered sliding activity exists among nuclear mammalian proteins.
Flexible ASIC (2005)

ASIC provides more than an order of magnitude advantage in terms of density, speed, and power requirement per gate. However, economic (cost of masks) and technological (deep micron manufacturability) trends favor FPGA as an implementation platform. In order to combine the advantages of both platforms and alleviate their disadvantages, recently a number of approaches, such as structured ASIC/regular fabrics, have been proposed. Our goal is to introduce an approach that has the same objective, but is orthogonal to those already proposed. The idea is to implement several ASIC designs in such a way that they share the datapath, memory structure, and several bottom layers of interconnect, while each design has only a few unique metal layers. We identified and addressed two main problems in our quest to develop a CAD flow for realization of such designs. They are: (i) the creation of the datapath, and (ii) the identification of common and unique interconnects for each design. Both problems are solved optimally using ILP formulations. We assembled a design flow platform using two new programs and the Trimaran and Shade tools. We quantitatively analyzed the advantages and disadvantages of the approach using the Mediabench benchmark suite.
Nonwovens modelling: a review of finite-element strategies (2015)

This is an Accepted Manuscript of an article published by Taylor &amp; Francis in The Journal of the Textile Institute on 16th March 2015, available online: http://www.tandfonline.com/10.1080/00405000.2015.1022088.
ChemInform Abstract: Isolation of Callipeltins A—C and of Two New Open‐Chain Derivatives of Callipeltin A from the Marine Sponge Latrunculia sp. A Revision of the Stereostructure of Callipeltins. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling (2021)

The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (expression of GTP-locked RagA, or RagA<sup>GTP</sup>) in mice resulted in a fatal energetic crisis at birth. Herein, we rescue neonatal lethality in RagA<sup>GTP</sup> mice and find morphometric and metabolic alterations that span glucose, lipid, ketone, bile acid and amino acid homeostasis in adults, and a median lifespan of nine months. Proteomic and metabolomic analyses of livers from RagA<sup>GTP</sup> mice reveal a failed metabolic adaptation to fasting due to a global impairment in PPARα transcriptional program. These metabolic defects are partially recapitulated by restricting activation of RagA to hepatocytes, and revert by pharmacological inhibition of mTORC1. Constitutive hepatic nutrient signaling does not cause hepatocellular damage and carcinomas, unlike genetic activation of growth factor signaling upstream of mTORC1. In summary, RagA signaling dictates dynamic responses to feeding-fasting cycles to tune metabolism so as to match the nutritional state.
Does meeting the Milan criteria at the time of recurrence of hepatocellular carcinoma after curative resection have an impact on prognosis? (2018)

Survival after first recurrence following curative primary resection for HCC was affected by MC at both time of resection and recurrence. Both the IN-rOUT and OUT-rIN MC groups with similar survival outcomes can be saved via curative treatment.
PATIENTS WITH MEDICARE AS THE PRIMARY PAYER ARE LESS LIKELY TO UNDERGO NEPHRON SPARING SURGERY (NSS) FOR RENAL CELL CARCINOMA (RCC) THAN THEIR PRIVATELY INSURED COUNTERPARTS (2009)

You have accessJournal of Urology1 Apr 2009PATIENTS WITH MEDICARE AS THE PRIMARY PAYER ARE LESS LIKELY TO UNDERGO NEPHRON SPARING SURGERY (NSS) FOR RENAL CELL CARCINOMA (RCC) THAN THEIR PRIVATELY INSURED COUNTERPARTS Alexander Kutikov, Karyn B. Stitzenberg, and Robert G. Uzzo Alexander KutikovAlexander Kutikov More articles by this author , Karyn B. StitzenbergKaryn B. Stitzenberg More articles by this author , and Robert G. UzzoRobert G. Uzzo More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60221-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PATIENTS WITH MEDICARE AS THE PRIMARY PAYER ARE LESS LIKELY TO UNDERGO NEPHRON SPARING SURGERY (NSS) FOR RENAL CELL CARCINOMA (RCC) THAN THEIR PRIVATELY INSURED COUNTERPARTS." The Journal of Urology, 181(4S), p. 77 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 77 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Alexander Kutikov More articles by this author Karyn B. Stitzenberg More articles by this author Robert G. Uzzo More articles by this author Expand All Advertisement PDF downloadLoading ...
Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy (2006)

Muscular dystrophies are characterized by primary wasting of skeletal muscle for which no satisfactory therapy is available. Studies in animal models have shown that stem cell-based therapies may improve the outcome of the disease, and that mesoangioblasts are promising stem cells in this respect. The efficacy of mesoangioblasts in yielding extensive muscle repair is, however, still limited. We found that mesoangioblasts treated with nitric oxide (NO) donors and injected intra-arterially in alpha-sarcoglycan-null dystrophic mice have a significantly enhanced ability to migrate to dystrophic muscles, to resist their apoptogenic environment and engraft into them, yielding a significant recovery of alpha-sarcolgycan expression. In vitro NO-treated mesoangioblasts displayed an enhanced chemotactic response to myotubes, cytokines and growth factors generated by the dystrophic muscle. In addition, they displayed an increased ability to fuse with myotubes and differentiating myoblasts and to survive when exposed to cytotoxic stimuli similar to those present in the dystrophic muscle. All the effects of NO were cyclic GMP-dependent since they were mimicked by treatment with the membrane permeant cyclic-GMP analogue 8-bromo-cGMP and prevented by inhibiting guanylate cyclase. We conclude that NO donors exert multiple beneficial effects on mesoangioblasts that may be used to increase their efficacy in cell therapy of muscular dystrophies.
Synthesis and modeling of RF integrated planar spiral inductor (2004)

The recent development of the wireless market has increased the interest in the integrated inductor for Radio Frequency Integrated Chip (RFIC) applications. Though Electromagnetic (EM) simulation is available, it is usually expensive, slow and difficult to integrate into the RFIC design flow. Therefore, the alternative option of a generic, simple yet accurate procedure to design the inductor is very desirable. Based on the physical model, an integrated inductor synthesis procedure has been developed and implemented in Microsoft EXCEL. This synthesis tool is able to identify the maximum quality factor (Q) at the operating frequency (e.g. 1.8 GHz for mobile communication, 2.45 GHz for wireless Local Area Network (LAN)) of the desired inductor very quickly. An example of synthesizing a 3 nH inductor is demonstrated using this tool. Besides that, another type of integrated inductor model known as extracted model is also needed for circuit simulation. An improved model extraction procedure has been proposed in this research and has been embedded in another EXCEL file. This new procedure has reduced the number of terms required and proved to be more accurate even in the region beyond the Self-Resonant Frequency (SRF). The above two types of integrated inductor modeling were then â€œcombinedâ€? into a new global integrated inductor model in SPICE, which is a compromise of accuracy (extracted model) and scalability (physical model). This model is accurate up to ~2 GHz, within an average error of 10 %. Using this new model, one can have the freedom to choose the value of inductance and more flexibility in circuit design. In addition, the layout optimization and circuit optimization can be done using the same model thus saving time and reducing cost. This is a novel integrated type of model that has never been published in any other research.
First human use of partial left ventricular heart support with the Circulite™ synergy™ micro-pump as a bridge to cardiac transplantation (2008)

In March 2007, a 46-year-old man without prior medical history suffered a large anterior myocardial infarction. Despite successful restoration of patency of the left anterior descending artery, he was left with an overall ejection fraction of 15%. He developed NYHA Class IV symptoms within 2 months and was accepted for heart transplantation. However, he continued to deteriorate over the ensuing 6 weeks and was re-admitted for treatment of dyspnea at rest.

The …
Latent Class Survival Models Linked by Principal Stratification to Investigate Heterogenous Survival Subgroups Among Individuals With Early-Stage Kidney Cancer (2016)

Rates of kidney cancer have been increasing, with small incidental tumors experiencing the fastest growth rates. Much of the increase could be due to increased use of CT scans, MRIs, and ultrasounds for unrelated conditions. Many tumors might never have been detected or become symptomatic in the past. This suggests that many patients might benefit from less aggressive therapy, such as active surveillance by which tumors are surgically removed only if they become sufficiently large. However, it has been difficult for clinicians to identify subgroups of patients for whom treatment might be especially beneficial or harmful. In this work, we use a principal stratification framework to estimate the proportion and characteristics of individuals who have large or small hazard rates of death in two treatment arms. This allows us to assess who might be helped or harmed by aggressive treatment. We also use Weibull mixture models. This work differs from much previous work in that the survival classes upon which principal stratification is based are latent variables. That is, survival class is not an observed variable. We apply this work using Surveillance Epidemiology and End Results-Medicare claims data. Clinicians can use our methods for investigating treatments with heterogeneous effects.
Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck (1991)

pp56lck is a member of the src family of tyrosine kinases mainly expressed in T lymphocytes. Src tyrosine kinases have been implicated in the control of cell growth and differentiation in different cell types, but the mechanism of regulation of these enzymes is poorly understood. In order to characterize the distinct species of pp56lck, we have produced high yields of enzymatically active wild type pp56lck using the eukaryotic baculovirus expression system in Spodoptera frugiperda insect cells (Sf9). We find that the various species of baculoviral pp56lck are not only differentially phosphorylated (on serine and tyrosine residues) but also heterogeneously myristylated. Surprisingly a non-myristylated, very active form of bv-pp56lck is found in the cytoplasm of Sf9 cells. Fractionation of T cells reveals that cytoplasmic pp56lck exists in T lymphocytes as well.
Triangle network secrecy (2014)

We characterize the secret message capacity of the triangle network, that consists of a source, a relay and a destination connected through orthogonal erasure channels. A passive eavesdropper, Eve, wiretaps any one of the three channels. The source and the relay can each generate unlimited private randomness; the relay and the destination can publicly provide strictly causal channel state information. Our achievable scheme is expressed through a linear program (LP) with 11 inequalities that captures a minimal set of secret key generation methods and the use of them for message encryption. Our outer bound is expressed also through a linear program, in this case with 41 constraints, constructed from general information inequalities. We prove that the optimal value of the outer bound LP is no larger than that of the scheme LP, which implies that the solution of the achievable scheme LP is the capacity. We find that equipping the relay with private randomness increases the secrecy rate by more than 40% in some cases and that cut-set bounds, directly applied in the network, are not always tight. Because the derivation of the inner and outer bound are both lengthy, we describe in this paper the achievability scheme, outline the outer bound, and provide the full derivations online [1]. We also make available Matlab functions that take as input the erasure probabilities and evaluate the inner and outer bounds.