gebhart/patrepeval huggingface dataset:
Performance of a hierarchically interconnected multiprocessor (2002)

A queuing model of a parallel processor with an interconnection network incorporating a hierarchy of paths is developed and analyzed. The model captures the behavior of the processors, the interconnection network, and the storage modules. The network considered includes fast paths that operate in the absence of contention and alternate paths with contention resolution. The network overall performance is shown to be close to that of a contention-free network of fast paths. It is shown that, as the load varies, this hierarchical interconnection network is robust with respect to ideal networks with no delay. An analysis of the effects of hot spots shows that processor throughput is limited by storage rather than communications bandwidth and that an upper bound on the processor utilization is inversely proportional to the miss probability. The analysis suggests that a fetch-and-add network could be incorporated into a connection hierarchy whose average performance is close to that of a network with no combining, so this may be an effective way to handle hot spots without much penalty to overall system performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Efficacia clinica di un preparato topico multicomponente in varie forme di dermatite eritematosa (2009)

A disposizione del dermatologo clinico esistono preparati multicomponenti formulati con l’ausilio di principi attivi selezionati di origine estrattiva. Oggetto di questo studio è stata la valutazione clinica di un formulato multicomponente, caratterizzato dalla presenza di tali ingredienti attivi, nel trattamento delle dermatiti eritematose ad eziologia varia che si possono manifestare nel neonato, in età pediatrica e nel soggetto adulto. I risultati ottenuti su 50 soggetti mostrano come tale preparato in esame si dimostri caratterizzato da buona efficacia antinfiammatoria e lenitiva con risultati apprezzabili già dopo 7 giorni di trattamento ed evidenti dopo 2 settimane. La sua efficacia è probabilmente legata alle sinergie derivanti dalle azioni farmacologiche dei singoli principi attivi.&#13;\n
Inverse Designed Flat Optics for Imaging Applications in the IR and beyond (2020)

Treating phase in the image plane to be a free parameter, we demonstrate multilevel diffractive lenses via inverse design enabling functionalities like achromaticity, depth-of-focus, wide-angle imaging, etc. for various imaging applications in the IR and beyond.
Permanent Attachment of Silicon Structures via Joule Heat Induced Welding (2011)

We introduce a new method for the permanent attachment of assembled silicon microstructures using the precise application of current for localized welding. The attachment technique for planar SOI structures was demonstrated using an assembly mechanism that allows the post-release adjustment of micromachined gaps. The concept utilizes a mechanical assembly technique that takes advantage of the motion reduction experienced by the individual beams of a folded suspension ultimately allowing sub-micron position control of released structures. The proposed mechanism was incorporated into the sense mode of a symmetrically decoupled MEMS tuning fork gyroscope in order to demonstrate its potential for the realization of high performance inertial sensors. Two types of mechanisms were implemented resulting in 7.8 and 8.8 % motion reduction allowing capacitive gaps of 7.5 μm to be adjusted to 1.67 μm; the gaps can be further reduced by alternate suspension designs and implemented on arbitrarily thick layers. After assembly, the mobile electrode structure was rigidly attached to the anchor by locally melting the interface via a controlled current. The weld is achieved by applying 15 V with a current limit of 3 mA across the latching mechanism resulting in the permanent attachment of the two structures. Thus, when the desired gap is achieved, the previously released anchor can be fixed to eliminate any potential spurious motion of the electrodes. Our results demonstrate feasibility of the approach, which can be extended beyond planar devices to include out of plane and die-level 3-D assembled structures that typically rely on epoxy bonding or solder assembly to maintain their shape.
Inhibition of Matrix Metalloproteinase Activities and Tightening of Tight Junctions by Diallyl Disulfide in AGS Human Gastric Carcinoma Cells (2011)

The effect of diallyl disulfide (DADS), a major component of an oil-soluble allyl sulfide garlic (Allium sativum) derivative, on the correlation between anti-invasive activity and tightening of tight junctions (TJs) was investigated in human gastric adenocarcinoma AGS cells. Our data indicated that the inhibitory effects of DADS on cell motility and invasiveness were found to be associated with increased tightness of the TJs, which was demonstrated by an increase in transepithelial electrical resistance. Activities of matrix metalloprotease (MMP)-2 and -9 in AGS cells were dose-dependently inhibited by treatment with DADS, and this was also correlated with a decrease in expression of their mRNA and proteins; however, tissue inhibitor of metalloproteinase (TIMP)-1 and -2 mRNA levels and proteins were increased. Additionally, immunoblotting results indicated that DADS repressed the levels of claudin proteins (claudin-2, -3, and -4), major components of TJs that play key roles in control and selectivity of paracellular transport. Although further studies are needed, these results suggest that DADS treatment may inhibit tumor cell motility and invasion and, therefore, act as a dietary source to decrease the risk of cancer metastasis.
P2‐393: Allopregnanolone as a regenerative therapeutic for Alzheimer's: Formulation development for clinical trials (2012)

Allopregnanolone (APα) stimulates proliferation of rodent and human neural progenitor cells in vitro and in triple transgenic Alzheimer's disease (3xTgAD) mice in vivo. APα was administered subcutaneously (SC; 1-100 mg/kg), transdermally (TD; 10-50 mg/kg), intranasally (IN; 3-10 mg/kg), intravenously (IV; 0.04-1.5 mg/kg) followed 1hr later by BrdU (100 mg/kg). Formulations of APα were developed through solubility tests and dose-range-finding and efficacy studies comparable to SC 10 mg/kg (PBS/5%EtOH). The SC control formulation (10 mg/kg) had no detectable sedation indicating that global neuroactivation of GABAergic pathways is not required for neurogenesis. From in vitro studies, intracellular calcium rise occurs rapidly within a one-minute period indicating that sustained activation of GABAAR may not be required. Results demonstrated that the SC formulation of APα significantly enhanced neurogenesis and significantly improved cognitive performance in pre-plaque 3xTgAD mice, restoring learning and memory to nonTg performance. Once/week dosing regimen maximized neurogenesis while concomitantly reducing AD pathology. Results of current analyses indicate promising therapeutic efficacy of TD and IN APα to promote regenerative capacity. Soluble SC formulations were more potent than suspensions and induced rapid sedation at higher concentrations. Bridging studies are underway to simulate SC administration by controlling IV infusion rate. Behavioral tests including sedation scores were designed to assess indicators of APα efficacy. We are currently conducting preclinical IND-enabling pharmacokinetic, pharmacodynamic and toxicology analyses. ADMET Predictor™ was used to estimate the biopharmaceutical properties of APα. Data from the literature on the pharmacokinetics and pharmacodynamics of APα in mice and humans were compared to PBPK/PD models built using GastroPlus™ to establish a prediction for a dosing regimen and expected human exposure in support of planned clinical trials in Alzheimer's patients. Validated PBPK/PD models were used to predict the plasma and brain concentrations of APα resulting from low doses (0.5 mg) with no predicted PD response up to a high dose (6 mg) with slight sedation, proposed in the P2a MAD study population. Simulated for males and females aged 60 to 80 years old. APα via multiple formulations and routes of administration induces the regenerative capacity of the brain with unique PK/PD profiles.
Highly Selective Color Filters Based on Hybrid Plasmonic–Dielectric Nanostructures (2022)

We demonstrate a novel transmission color filter design that exploits both dielectric and plasmonic resonances to establish a highly color-selective device, reaching an experimental full-width at half-maximum (fwhm) that is only half that of previously demonstrated cost-effective color filter devices for the same peak transmission and better out-of-band rejection. The measured fwhm is only 25 nm, and the peak transmission reaches up to 53%. The filter uses the interference of Fabry-Pérot resonances and guided-mode resonances in two separated dielectric slabs to achieve this excellent fwhm while relying on propagating surface plasmon polaritons to achieve the excellent out-of-band rejection. A simulation study elucidates the nature of the optical modes in the device and their interference mechanisms and reveals the most important design considerations. Fabrication was done in a CMOS pilot line and is cost-effective, as it requires only two metal patterning steps. Fabrication imperfections are discussed, together with strategies to mitigate them. We show the correct mitigation of these imperfections leads to further performance gain, enabling a full-width at half-maximum down to 20 nm and a peak transmission beyond 60%. We believe this novel filter design is a powerful concept to improve the spectral resolution of color filters for cost-effective multispectral imaging. Beyond multispectral imaging, the design could be adapted for other applications that require on-chip spectral filtering in a thin form factor.
Temperature Effects on Trench-Gate Punch-Through IGBTs (2004)

The switching characteristics (turn-on and turn-off) and forward conduction drop of trench-gate punch-through insulated gate bipolar transistors (IGBTs) are examined over a temperature range of from -50/spl deg/C to 125/spl deg/C. An analytical description of the forward conduction voltage drop is presented based on temperature dependencies of the appropriate physical parameters and mechanisms. A physics-based PSpice model, incorporating much of the device behavior, is also described. Results from the model are compared to experimental waveforms.
CD137 co-stimulation and blocking PD-1 enhances NK cell-mediated target cell lysis by CD30/CD16A TandAb AFM13. (2015)

3050 Background: The CD30/CD16A bispecific tetravalent TandAb antibody AFM13 recruits and activates NK cells by specific binding to CD16A for targeted lysis of CD30+ tumor cells. Given promising clinical activity and safety profile of AFM13 and proof-of-mechanism demonstrating dependence on the immune response, potential synergy of AFM13 and checkpoint inhibitors was evaluated. Methods: Efficacy was assessed by in vitro cytotoxicity with human PBMCs, enriched NKs, and CD30+ target cells as well as cell line and patient-derived xenograft in vivo models with AFM13, anti-CTLA-4, anti-PD-1, or anti-CD137 antibodies. Results: AFM13 demonstrated higher potency and efficacy toward target and effector cells relative to other CD30+ antibody formats (EC50 = 15pM). These favorable properties resulted in superior cytotoxicity when AFM13 was incubated with CD30+ tumor cells and enriched NK cells. Single treatment with AFM13 at suboptimal concentrations (1 pM) induced effector-to-target cell-dependent lysis of CD30+ lymphoma cells up to 40% using enriched NK cells. Immune-modulating antibodies alone mediated substantially lower lysis ( < 25%). However, the addition of anti-PD-1 or anti-CD137 to AFM13 strongly enhanced specific lysis up to 70%, whereas the addition of anti-CTLA-4 to AFM13 showed no beneficial effect. The most impressive increase of efficacy was observed when AFM13 was applied together with a combination of anti-PD-1 and anti-CD137. In vivo, synergy of AFM13 and CPI combination was observed with each CPI tested and augmented with anti-PD1 (regression in 9/10 tumors), ant-CTLA-4 (3/10), and anti-CD137 mAb (3/10) and influenced by presence of regulatory T cells, NK cells, and Th1 cytokines. Conclusions: Our findings support engagement of NK cells using CD30/CD16A TandAbs by binding to CD16A does not completely exploit the efficacy of NK cells. Therefore combination trials performed with companion intratumoral assessment may personalize dual-Ab therapy and augment the efficacy of AFM13 and CPIs.
Multi-Biomarkers Panel in Cardiac Surgery Patients (2019)

FIGURE 4. Crinitodiscus ozkani sp. n. (female): A chelicera, B epistome, C tritosternum, D lacinia, E venter of gnathosoma, F palp.
A formal solution to rewriting attacks on SOAP messages (2008)

In Service Oriented Architecture Web Services, communication among services is banking on XML-Based messages, called SOAP messages. These messages are prone to attacks that are classified in literature as XML rewriting attacks. Since rewriting is a formal mechanism used in formal language theory, and the rewriting attack problem is designed under the framework of formal language theory, the solution also lies under the same framework. In this paper we propose a formal solution to XML rewriting attacks on SOAP messages using regular tree grammar. To the best of our knowledge this is the first formal solution to this problem. We define current XML signatures used in a SOAP message as context-free signature. The formal solution proposed here is a context-sensitive XML signature. To address the additional requirements of SOAP extensibility model, where a SOAP message can pass through several intermediaries before reaching the final receiver, an adaptive variant of context-sensitive signature is also proposed. The solution addresses different forms of XML rewriting attacks. An analysis of the solution is also given in the paper.
Application of negative differential conductance in Al/AlOx single-electron transistors for background charge characterization (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hubert C. George, Mathieu Pierre, Xavier Jehl, Alexei O. Orlov, Marc Sanquer, Gregory L. Snider; Application of negative differential conductance in Al/AlOx single-electron transistors for background charge characterization. Appl. Phys. Lett. 25 January 2010; 96 (4): 042114. https://doi.org/10.1063/1.3298557 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Atomic-scale investigation of structural defects in GaN layer on c-plane sapphire substrate during initial growth stage (2016)

Abstract Structural defects in the initial growth stages of GaN on sapphire, including stacking faults (SFs), threading dislocations (TDs), and mosaic structure containing grain boundaries, are investigated at the atomic scale. Individual grains in the as-deposited low temperature-GaN buffer layer are found to have twists correlated with those of the adjacent grains. These grains have little similarity on the stacking sequences, and the atomic arrangement on each side of the grain boundaries may be rearranged by annealing to achieve higher similarity in the stacking sequence. The TD identified as a -type at the top of the SFs-rich interfacial region is thought to originate from Frank partial dislocations. The Frank partial dislocation produces a distorted wurtzite-type structure. At the intermediate region of the basal-plane stacking fault between Frank and Shockley partial dislocations, the TD relieves the distortion in the wurtzite-type structure. In the TD, the wurtzite structure slips relative to the surrounding wurtzite.
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice (2021)

Improving the standard of clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small molecule antivirals like remdesivir (RDV) and biologics such as human monoclonal antibodies (mAb) have demonstrated therapeutic efficacy against SARS-CoV-2, the causative agent of COVID-19. However, it is not known if combination RDV/mAb will improve outcomes over single agent therapies or whether antibody therapies will remain efficacious against variants. In kinetic studies in a mouse-adapted model of ancestral SARS-CoV-2 pathogenesis, we show that a combination of two mAbs in clinical trials, C144 and C135, have potent antiviral effects against even when initiated 48 hours after infection. The same antibody combination was also effective in prevention and therapy against the B.1.351 variant of concern (VOC). Combining RDV and antibodies provided a modest improvement in outcomes compared to single agents. These data support the continued use of RDV to treat SARS-CoV-2 infections and support the continued clinical development of the C144 and C135 antibody combination to treat patients infected with SARS-CoV-2 variants.
Enhanced Uplink Coverage for 5G NR: Frequency-Domain Spectral Shaping With Spectral Extension (2021)

This paper describes and investigates a novel concept of frequency-domain spectral shaping (FDSS) with spectral extension for the uplink (UL) coverage enhancement in 5G New Radio (NR), building on discrete Fourier transform spread orthogonal frequency-domain multiplexing (DFT-s-OFDM). The considered FDSS concept is shown to have large potential for reducing the peak-to-average-power ratio (PAPR) of the signal, which directly impacts the feasible maximum transmit power under practical nonlinear power amplifiers (PAs) while still meeting the radio frequency (RF) emission requirements imposed by the regulations. To this end, the FDSS scheme with spectral extension is formulated, defining filter windows that fit to the 5G NR spectral flatness requirements. The PAPR reduction capabilities and the corresponding maximum achievable transmit powers are evaluated for a variety of bandwidth allocations in the supported 5G NR frequency ranges 1 and 2 (FR1 and FR2) and compared to those of the currently supported waveforms in 5G NR, particularly π/2-BPSK with FDSS without spectral extension and QPSK without FDSS. Furthermore, an efficient receiver structure capable of reducing the noise enhancement in the equalization phase is proposed. Finally, by evaluating the link-level performance, together with the transmit power gain, the overall coverage enhancement gains of the method are analyzed and provided. The obtained results show that the spectrally-extended FDSS method is a very efficient solution to improve the 5G NR UL coverage clearly outperforming the state-of-the-art, while being also simple in terms of computational complexity such that the method is implementation feasible in practical 5G NR terminals.
Range measurement photon by photon (1989)

The possible use of parametric fluorescence photon slipping in range measurement experiments is described. In the proposed method a CW laser is used and the return travel time of individual photons is used to estimate the range. A signal to noise ratio analysis is presented and comparisons are made with the conventional optical method of pulsed range finding. Conditions under which a photon splitting technique could be advantageous are established
Experimental study of nanosecond-order wavelength switching in short-cavity DBR lasers (2008)

We experimentally investigated fast wavelength switching in short-cavity active DBR (ADBR) lasers. Our fabricated 4-ch laser array continuously covered a 12-nm range in the condition that the switching time is expected to be less than 10 nanoseconds.
A GSM/GPRS mixed-signal baseband IC (2005)

A dual-core baseband processor IC for GSM/GPRS cellular phone applications is built in a 0.13 /spl mu/m CMOS process with 5 levels of copper interconnect and contains a high level of mixed-signal integration which includes: 1 GHz CMOS synthesizer, 10 b general-purpose ADC, two 14 b ADCs, power amplifier controller, and 13 b voice codec.
Dilution effect on magnetic properties of Co3O4 nanocrystals (2000)

We have prepared diluted systems of Co3O4 nanocrystals dispersed in an amorphous silicate by calcination of molecular sieve soaked in precursor solutions with concentrations of 0.01 and 0.1 mol/l. For both systems we have observed the disappearance of the antiferromagnetic phase transition at 33 K of bulk Co3O4, a difference in the dc susceptibility between field cooling and zero field cooling, and the frequency dependence of the ac susceptibility. Nonlinear susceptibility measurements demonstrated that the systems from the solution of 0.01 and 0.1 mol/l were in superparamagnetic and spin glass phases, respectively. The 0.01 mol/l solution system showed no peaks at any temperature, although the peak temperature for the 0.1 mol/l solution system was 18–22 K. The interparticle interactions were independent and collective for the systems from 0.01 and 0.1 mol/l solutions, respectively.
An Experimental Implementation of the Tilde Naming System (1987)

ABSTRACT: The Tilde naming system identifres files in a distributed computing system in a novel way, providing a consistent mechanism for referencing both local and remote files that is independent of the details of the underlying computing environment. The Tilde naming system achieves this independence by providing each user with control of a private name evaluation environment. In contrast, several contemporary distributed systems try to disassociate file names from the structure of the computing environment by hiding complex, heterogeneous computing systems beneath a uniform, global name evaluation environment. The private naming environments supported by Tilde naming incorporate local and remote names into a single naming mechanism while improving software portability and retaining the familiar advantages of hierarchical file naming systems. We have constructed an experimental implementation of the Tilde naming system, and created a computing environment sufficiently rich to support significant software development. With this prototype, we have been able to study the effects of the Computing Systems, Vol. 3 &amp;apos;No. 4&amp;apos;Fall 1990 487Tilde naming scheme on the system&amp;apos;s user interface, software project development, information sharing and other issues. This paper summarizes Tilde naming and discusses insights into naming mechanisms gained through the use of the experimental system. I.
ChemInform Abstract: Design, Synthesis and Biological Activity of 7‐O‐(4‐O‐Acetyl‐3‐iodo‐2,3,6‐trideoxy‐α‐L‐arabino‐hexopyranosyl) daunomycinone and 7‐O‐(3‐Chloro‐2,3,6‐trideoxy‐4‐O‐propanoyl‐α‐L‐lyxo‐hexopyranosyl) daunomycinone. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.