gebhart/patrepeval huggingface dataset:
Concepts on an Integrated Design Approach to the Active Control of Structurally Radiated Noise (ASAC) (1995)

This work describes a range of issues relating to the implementation of active control for noise and vibration problems. It is important in the commercialization of this technology to consider these and many other factors relating to design of these systems. Many of the concepts required for efficient implementation have not been considered and it is important to begin giving design consideration to these aspects. A design technique based upon the eigenbehavior of feedforward controlled systems is developed and applied to control radiation from structures. Integration of the control system with the physical system dynamics allows the eigenproperties to be defined to meet a prescribed design criteria. Here the technique is demonstrated to implement a structural system that inefficiently couples vibration energy to acoustic energy. In addition, an approach to integrate “knowledge” about actuator configurations into an active control system that reduces spillover effects into structural vibrations is demonstrated. This approach has the advantages that no additional hardware is required while also reducing the order of the control system in terms of degrees of freedom. Finally, some design trade-offs between the passive material properties of an active trim panel and control system performance are examined. Improved performance can be attained but at the cost of additional weight.
PLM-based channelization sequences for multi-code wideband DS-CDMA (2005)

A key problem in multi-code DS-CDMA communication systems is the limited resource in the code domain, i.e. limited number of available orthogonal channelization sequences. This problem causes the overall interference to be a limiting factor, especially when high symbol rate signaling is considered. In order to resolve this problem the literature has proposed many code management techniques, based essentially on code sharing mechanisms among the active users in the system. In this paper we propose a simpler method for the performance optimization of the multi-code DS-CDMA communication systems, based on the design of the channelization sequences used in the system. The optimal channelization sequences are implemented by means of chaotic piece wise linear Markov (PLM) sequences.
The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells (2006)

Basophil numbers are typically elevated in chronic myeloid leukemia (CML) and increase during disease progression. Histamine is an essential mediator and marker of basophils and is highly up-regulated in CML. We examined the biochemical basis of histamine synthesis in CML cells. The CML-specific oncoprotein BCR/ABL was found to promote expression of histidine decarboxylase (HDC) and synthesis of histamine in Ba/F3 cells. Moreover, the BCR/ABL tyrosine kinase inhibitors imatinib (STI571) and nilotinib (AMN107) decreased histamine levels and HDC mRNA expression in BCR/ABL-transformed Ba/F3 cells, in the CML-derived basophil cell line KU812, and in primary CML cells. Synthesis of histamine was found to be restricted to the basophil compartment of the CML clone and to depend on signaling through the PI3-kinase pathway. CML cells also expressed histamine receptors (HRs), including HR-1, HR-2, HR-4, and histamine-binding CYP450 isoenzymes which also serve as targets of HR antagonists. The HR-1 antagonists loratadine and terfenadine, which bind to CYP450, were found to counteract proliferation of CML cells, whereas no growth inhibition was observed with the HR-1 antagonist fexofenadine which is not targeted or metabolized by CYP450. Moreover, DPPE, an inhibitor of histamine-binding CYP450 isoenzymes, produced growth inhibition in CML cells. Together, these data show that BCR/ABL promotes histamine production in CML cells and that certain HR-targeting drugs exert antileukemic effects on CML cells.
Process for making dense thin films (2023)

Provided are low-cost, mechanically strong, highly electronically conductive porous substrates and associated structures for solid-state electrochemical devices, techniques for forming these structures, and devices incorporating the structures. The invention provides solid state electrochemical device substrates of novel composition and techniques for forming thin electrode/membrane/electrolyte coatings on the novel or more conventional substrates. In particular, in one embodiment the invention provides techniques for firing of device substrate to form densified electrolyte/membrane films 5 to 20 microns thick. In another embodiment, densified electrolyte/membrane films 5 to 20 microns thick may be formed on a pre-sintered substrate by a constrained sintering process. In some cases, the substrate may be a porous metal, alloy, or non-nickel cermet incorporating one or more of the transition metals Cr, Fe, Cu and Ag, or alloys thereof.
An Ultra-Compact Differentially Tuned 6-GHz CMOS LC-VCO With Dynamic Common-Mode Feedback (2007)

A fully integrated 0.024 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> differentially tuned 6-GHz LC-VCO for 6+Gb/s high-speed serial (HSS) links in 90-nm bulk CMOS is presented. It is smaller than any LC-VCO reported to date at this frequency. Its size is comparable with ring oscillators but it has significantly better phase noise. A circuit technique is introduced to dynamically set the common-mode (CM) voltage of the differential varactor control signals equal to the VCO's CM. Compared to other commonly used techniques such as replica biasing, this technique does not dissipate any extra power and it accurately tracks the output common-mode voltage of the VCO during the oscillations. Using a differential control a very wide tuning range from 4.5 GHz to 7.1 GHz (45%) is achieved. The VCO has a measured phase noise of -117.7 dBc/Hz at a 3-MHz offset from a 5.63-GHz carrier while dissipating 14 mW from a 1.6-V supply.
Ionization-induced optical heterogeneity and ion-like direct emission in 1-nm silicon nanoparticle grains: Prospect for fast optical modulation (2022)

Silicon, a highly symmetric and homogeneous material, does not exhibit fast optical modulation. Recent classical electrodynamics simulations, however, demonstrated transient optical heterogeneity in silicon nanostructures, in which a high-density of excitonic electron–hole pair plasma and charge is created. The phenomenon, however, requires a specific particle size (∼100 nm diameter) and a high-density (1023/cc) plasma. We examine here the quantum aspect of the heterogeneity in 1-nm Si nanoparticles. Due to the small number of atoms, 1 nm nanoparticles are amenable to the Hartree–Fock first principle atomistic quantum theory simulations procedure, while single ionization events are sufficient to provide high charge density (2 × 1021/cc). The simulations show that the charge distribution in singly charged 1-nm particles is nonlinear and heterogeneous, accompanied with structural distortion that produces an electric dipole moment. Electronically, the simulations show that the single charge induces stationary Coulomb states that riddle the bandgap of the neutral particle, with dipole-allowed transitions, effectively inducing partial conducting-like behavior. Optically, when the charge is produced by ionizing UV radiation, the ionized particle survives and exhibits both extended (wide-band) as well as atomic- or ion-like sharp emission, in agreement with infrared polarimetry and spectroscopy observations in the solar coronal holes, as well as under synchrotron irradiation. Not only do ionized Si nanoparticles (charged nanosilicon grains) afford fast optical modulations, but they may also prove pivotal for understanding features of interstellar medium, observed throughout the Milky Way and other galaxies, including spectroscopic and material composition, as well as neutral hydrogen abundancy.
Jitter estimation methodology for clock chips (2002)

A simulation methodology is developed for clock chips to predict their AC performance more accurately. Power bus modeling is shown to lead to more accurate and predictable jitter values. Jitter variation is plotted for a typical set of 2CPU-7PCI simultaneously switching pads, for the variation in inductance, capacitive load and frequency.
Comparison of the Mechanical Properties of Self-Assembled Langmuir Monolayers of Nanoparticles and Phospholipids (2013)

Nanoparticles with hydrophobic capping ligands and amphiphilic phospholipids are both found to self-assemble into monolayer films when deposited on the air water interface. By separately measuring the anisotropic stress response of these films under uniaxial compression, we obtain both the 2D compressive and shear moduli of a range of different thin nanoparticle and phospholipid films. The compressive moduli of both nanoparticle and lipid films in the solid phase are on the same order of magnitude, whereas the shear moduli of the lipid films are found to be significantly lower. Additionally the moduli of the nanoparticle films depended substantially on the polydispersity of the constituent particles: broader size distribution lowered the stiffness of the nanoparticle film.
Enforcing QoT via PCE in Multi Bit-Rate WSONs (2011)

Due to network upgrades, in centralized wavelength switched optical networks (WSONs), path computation element (PCE) has to guarantee the coexistence of different bit-rates in the same WSON. In particular, considering cross-phase modulation (XPM) is a challenging issue in multi bit-rate networks. In this paper, we propose three schemes based on PCE to provision lightpaths in multi bit-rate (e.g., 10-40-100-Gb/s) WSONs.
Driving performance and control of a micro artificial muscle cell using electro-conjugate fluid (2006)

As a man-machine interaction increases its importance in robotics and mechatronics fields, a soft robot inspired from natural systems becomes one of the research trends. There are several research topics related to soft robots such as soft structures or artificial skins, compliance control, soft actuators or artificial muscles, and so on. For the natural muscle potentially has great flexibility, the authors believe the artificial muscle actuator must have a great potential in soft robots. Hence in this study we develop a new type of micro artificial muscle cell, which is an element of an integrated artificial muscle, using electro-conjugate fluid and measure its driving performances. In addition, position control characteristics are also clarified by experiments. As a result, the micro artificial muscle cell using electro-conjugate fluid shows quite good control performances
Deep Learning in the Enhanced Cloud (2017)

Deep Learning has emerged as a singularly critical technology for enabling human-like intelligence in online services such as Azure, Office 365, Bing, Cortana, Skype, and other high-valued scenarios at Microsoft. While Deep Neural Networks (DNNs) have enabled state-of-the-art accuracy in many intelligence tasks, they are notoriously expensive and difficult to deploy in hyperscale datacenters constrained by power, cost, and latency. Furthermore, the escalating (and insatiable) demand for DNNs comes at an inopportune time as ideal silicon scaling (Moore's Law) comes to a diminishing end.
Synthesis of a novel high sensitive photo‐radical initiator with good thermal stability based on naphthalic‐1,8‐N‐alkylimide derivatives (2005)

Abstract A new high‐sensitive photo‐radical initiator, N ‐[2‐(2‐acryloyloxyethoxy)ethyl]‐1,8‐naphthalimide (NI6), with good thermal stability based on naphthylimide derivative was developed. NI6 was prepared by the condensation of N ‐[2‐(2‐hydroxyethoxy)ethyl]‐1,8‐naphthalimide and acryloyl chloride in the presence of 4‐dimethylaminopyridine. The film consisting of NI6 and pentaerythritol triacrylate (PETA) showed higher photosensitivity than those containing conventional photo‐radical initiators such as acrylic acid 2‐(2‐{2‐[2‐(4‐benzoyl‐phenoxy)‐ethoxy]‐ethoxy}‐ethoxy)‐ethyl ester, cyclohexylmaleimide, and the resulting film exhibited very high transmittance over 400 nm. The thermal stability of NI6 was very high and no decomposed residues were observed from the film consisting of NI 6 after heating at 250 °C for 1 h. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 5571–5580, 2005
Rapid and sensitive detection of viral nucleic acids using silicon microchips (2018)

Clinical laboratory-based nucleic acid amplification tests (NAT) play an important role in diagnosing viral infections. However, laboratory infrastructure requirements and their failure to diagnose at the point-of-need (PON) limit their clinical utility in both resource-rich and -limited clinical settings. The development of fast and sensitive PON viral NAT may overcome these limitations. The scalability of silicon microchip manufacturing combined with advances in silicon microfluidics present an opportunity for development of rapid and sensitive PON NAT on silicon microchips. In the present study, we present rapid and sensitive NAT for a number of RNA and DNA viruses on the same silicon microchip platform. We first developed sensitive (4 copies per reaction) one-step RT-qPCR and qPCR assays detecting HCV, HIV, Zika, HPV 16, and HPV 18 on a benchtop real-time PCR instrument. A silicon microchip was designed with an etched 1.3 μL meandering microreactor, integrated aluminum heaters, thermal insulation trenches and microfluidic channels; this chip was used in all on-chip experiments. Melting curve analysis confirmed precise and localized heating of the microreactor. Following minimal optimization of reaction conditions, the bench-scale assays were successfully transferred to 1.3 μL silicon microreactors with reaction times of 25 min with no reduction in sensitivity, reproducibility, or reaction efficiencies. Taken together, these results demonstrate that rapid and sensitive detection of multiple viruses on the same silicon microchip platform is feasible. Further development of this technology, coupled with silicon microchip-based nucleic acid extraction solutions, could potentially shift viral nucleic acid detection and diagnosis from centralized clinical laboratories to the PON.
Teaching medical device design using design control (2011)

The design of medical devices requires an understanding of a large number of factors, many of which are difficult to teach in the traditional educational format. This subject benefits from using a challenge-based learning approach, which provides focused design challenges requiring students to understand important factors in the context of a specific device. A course was designed at San Diego State University (CA, USA) that applied challenge-based learning through in-depth design challenges in cardiovascular and orthopedic medicine, and provided an immersive field, needs-finding experience to increase student engagement in the process of knowledge acquisition. The principles of US FDA 'design control' were used to structure the students' problem-solving approach, and provide a format for the design documentation, which was the basis of grading. Students utilized a combination of lecture materials, industry guest expertise, texts and readings, and internet-based searches to develop their understanding of the problem and design their solutions. The course was successful in providing a greatly increased knowledge base and competence of medical device design than students possessed upon entering the course.
Supplementary Figure 2 from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by <i>DDR2</i> Gatekeeper Mutation and <i>NF1</i> Loss (2023)

&lt;p&gt;PDF - 61KB, Ectopic expression of IL6ST A664S or RNAi-mediated knockdown of EphA7 do not lead to a change in dasatinib sensitivity in NCI-H2286.&lt;/p&gt;
Osteosarcopenia: cross-talking between muscle and bone (2016)

Evolving Treatment Strategies for Osteoporosis: Signaling a change in the conversation Sponsor: MSD&lt;br/&gt;Evolving Treatment Strategies for Osteoporosis: Signaling a change in the conversationSponsor: MSD
The fast nucleation/growth of Co3O4nanowires on cotton silk: the facile development of a potentiometric uric acid biosensor (2022)

In this study, we have used cotton silk as a source of abundant hydroxyl groups for the fast nucleation/growth of cobalt oxide (Co<sub>3</sub>O<sub>4</sub>) nanowires <i>via</i> a hydrothermal method. The crystal planes of the Co<sub>3</sub>O<sub>4</sub> nanowires well matched the cubic phase. The as-synthesized Co<sub>3</sub>O<sub>4</sub> nanowires mainly contained cobalt and oxygen elements and were found to be highly sensitive towards uric acid in 0.01 M phosphate buffer solution at pH 7.4. Importantly, the Co<sub>3</sub>O<sub>4</sub> nanowires exhibited a large surface area, which was heavily utilized during the immobilization of the enzyme uricase <i>via</i> a physical adsorption method. The potentiometric response of the uricase-immobilizing Co<sub>3</sub>O<sub>4</sub> nanowires was measured in the presence of uric acid (UA) against a silver/silver chloride (Ag/AgCl) reference electrode. The newly fabricated uric acid biosensor possessed a low limit of detection of 1.0 ± 0.2 nM with a wide linear range of 5 nM to 10 mM and sensitivity of 30.6 mV dec<sup>-1</sup>. Additionally, several related parameters of the developed uric acid biosensor were investigated, such as the repeatability, reproducibility, storage stability, selectivity, and dynamic response time, and these were found to be satisfactory. The good performance of the Co<sub>3</sub>O<sub>4</sub> nanowires was verified based on the fast charge-transfer kinetics, as confirmed <i>via</i> electrochemical impedance spectroscopy. The successful practical use of the uric acid biosensor was demonstrated based on the recovery method. The observed performance of the uricase-immobilizing Co<sub>3</sub>O<sub>4</sub> nanowires revealed that they could be considered as a promising and alternative tool for the detection of uric acid under both <i>in vitro</i> and <i>in vivo</i> conditions. Also, the use of cotton silk as a source of abundant hydroxyl groups may be considered for the remarkably fast nucleation/growth of other metal-oxide nanostructures, thereby facilitating the fabrication of functional electrochemical devices, such as batteries, water-splitting devices, and supercapacitors.
Mimotope‐hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease‐associated epitope mimicry may explain low cancer burden in developing nations (2004)

It is generally observed that countries with heavy infectious burden show lower cancer incidence as compared to more affluent nations. With the emerging paradigm on microbial heat shock proteins (hsps) as molecular link between infections and autoimmune diseases, we posit a new hypothesis, the "mimotope-hormesis", on the immunologic impact of infections on regional cancer prevention. According to this, assaults of infection during early adulthood could fortify the immune system to evoke more potent defenses against late-onset diseases, such as cancer, via autoimmunity. Interestingly, both experimental and clinical data support the beneficial role of autoimmunity in long-term cancer survivors. We illustrate this by a comprehensive in silico mimotope (epitope mimicry) analysis of human infectious pathogens against mortalin (mthsp70/PB74/GRP75), a type of hsp70 protein involved in control of cell proliferation, immortalization and tumorigenesis.
Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice (2018)

Aging is the biggest risk factor for several neurodegenerative diseases. Parabiosis experiments have established that old mouse brains are improved by exposure to young mouse blood. Previously, our lab showed that delivery of Growth Differentiation Factor 11 (GDF11) to the bloodstream increases the number of neural stem cells and positively affects vasculature in the subventricular zone of old mice. Our new study demonstrates that GDF11 enhances hippocampal neurogenesis, improves vasculature and increases markers of neuronal activity and plasticity in the hippocampus and cortex of old mice. Our experiments also demonstrate that systemically delivered GDF11, rather than crossing the blood brain barrier, exerts at least some of its effects by acting on brain endothelial cells. Thus, by targeting the cerebral vasculature, GDF11 has a very different mechanism from that of previously studied circulating factors acting to improve central nervous system (CNS) function without entering the CNS.
Compact combined antenna with dual dipolar‐type radiation (2003)

Abstract Two dipolar radiating sources have been combined in a compact structure to provide a dual orthogonal omnidirectional coverage. A dual‐port antenna configuration using this concept has been designed to operate at I.S.M. 2.4‐GHz frequency band. Experimental results concerning S parameters and radiation characteristics are compared to simulation results. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 38: 415–418, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11077
Nonblinking Plasmonic Quantum Dot Assemblies for Multiplex Biological Detection (2012)

Nonblinking nanosystems are prepared by layer-by-layer polyelectrolyte deposition, which precisely controls the stoichiometry and the distance between quantum dots (QDs) and gold nanoparticles (GNPs). Conjugation of biorecognition molecules to these nanobarcodes enables cell targeting and entry with prolonged retention and minimal toxicity.
The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application (2023)

In the present era of global warming and dramatically increased environmental pollution posing a threat to animal life, the understanding and manipulation of organisms' resources of stress tolerance is apparently a question of survival. Heat stress and other forms of stressful factors induce a highly organized response of organisms at the cellular level where heat shock proteins (Hsps) and in particular Hsp70 family of chaperones are among the major players in the protection from the environmental challenge. The present review article summarizes the peculiarities of the Hsp70 family of proteins protective functions being a result of many millions of years of adaptive evolution. It discusses the molecular structure and specific details of <i>hsp70</i> gene regulation in various organisms, living in diverse climatic zones, with a special emphasis on the protective role of Hsp70 in adverse conditions of the environment. The review discusses the molecular mechanisms underlying Hsp70-specific properties that emerged in the course of adaptation to harsh environmental conditions. This review also includes the data on the anti-inflammatory role of Hsp70 and the involvement of endogenous and recombinant Hsp70 (recHsp70) in proteostatic machinery in various pathologies including neurodegenerative ones such as Alzheimer's and Parkinson's diseases in rodent model organisms and humans <i>in vivo</i> and <i>in vitro</i>. Specifically, the role of Hsp70 as an indicator of disease type and severity and the use of recHsp70 in several pathologies are discussed. The review discusses different roles exhibited by Hsp70 in various diseases including the dual and sometimes antagonistic role of this chaperone in various forms of cancer and viral infection including the SARS-Cov-2 case. Since Hsp70 apparently plays an important role in many diseases and pathologies and has significant therapeutic potential there is a dire need to develop cheap recombinant Hsp70 production and further investigate the interaction of externally supplied and endogenous Hsp70 in chaperonotherapy.