gebhart/patrepeval huggingface dataset:
INO: Interplanetary network of optical lattice clocks (2019)

The new technique of measuring frequency by optical lattice clocks now approaches to the relative precision of [Formula: see text]. We propose to place such precise clocks in space and to use Doppler tracking method for detecting low-frequency gravitational wave below 1[Formula: see text]Hz. Our idea is to locate three spacecrafts at one A.U. distance (say at L1, L4 and L5 of the Sun–Earth orbit), and apply the Doppler tracking method by communicating “the time” each other. Applying the current available technologies, we obtain the sensitivity for gravitational wave with third- or fourth-order improvement ([Formula: see text] or [Formula: see text] level in [Formula: see text]–[Formula: see text][Formula: see text]Hz) than that of Cassini spacecraft in 2001. This sensitivity enables us to observe black hole (BH) mergers of their mass greater than [Formula: see text] in the cosmological scale. Based on the hierarchical growth model of BHs in galaxies, we estimate the event rate of detection will be 20–50 a year. We nickname “INO” (Interplanetary Network of Optical Lattice Clocks) for this system, named after Tadataka Ino (1745–1818), a Japanese astronomer, cartographer, and geodesist.
Cr(III) Complexes Bearing a β-Ketoimine Ligand for Olefin Polymerization: Are There Differences between Coordinative and Covalent Bonding? (2022)

β-ketoimines are extensively applied for the synthesis of organometallic complexes intended as (pre)catalysts for a variety of chemical transformations. We were interested in the synthesis of two Cr complexes bearing a simple bidentate β-ketoimine (L), with different ligand binding modes, as well as their application as a precatalyst in the polymerization of olefins. Complex 1 (L2CrCl3) was obtained by direct reaction of L with CrCl3(THF)3, while, for the synthesis of complex 2 (LCrCl2), the ligand was first deprotonated with nBuLi, giving the β-ketoiminato ligand L─Li+, and then reacted with CrCl3(THF)3. Characterization of the complexes proved that the Cr(III) ion is coordinatively bonded to L in 1, while it is covalently bonded to L in 2. The complexes were then used as precatalysts for the polymerization of ethylene and various cyclic olefins. Upon activation with methylaluminoxane, both the complexes exhibited poor activity in the polymerization of ethylene, whilst they exhibit good productivity in the polymerization of cyclic olefins, affording semicrystalline oligomers, without a significant difference between 1 and 2. To gain more insight, we investigated the reaction of the complexes with the Al-cocatalyst by IR and UV-Vis spectroscopies. The results proved that, in case of 1, the Al-activator deprotonates the ligand, bringing to the formation of an active species analogous to that of 2.
Simple Receiving Scheme in 100-GHz DD OFDM RoF Systems Employing Low-Sampling-Rate ADCs and Digital Preprocess (2015)

A simple low-sampling-rate receiving scheme is proposed for W-band OFDM-RoF systems. Using the proposed preprocess, aliasing-free subcarriers can be received, and employing the optimized delays to ADCs can achieve the performance insensitive to sampling rate.
Noise management features of the open speech platform (2019)

In this contribution, we present the noise management features of the Open Speech Platform (OSP) for hearing aid (HA) research. OSP includes basic HA modules (i) subband decomposition, (ii) wide dynamic range compression and (iii) adaptive feedback cancellation; a baseline single-channel speech enhancement (SE) based on Wiener filtering for noise subtraction. We extended OSP noise management to include a generalized sidelobe cancellation (GSC) beamforming between left and right channels, followed by the SE. Time is the scarcest resource, followed by central processing unit (CPU) resources in commercial HAs. With the proposed GSC + SE approach, we were both time and CPU limited. Release 2019a of OSP has 5.6 ms end-to-end latency and GSC requires an additional 5 ms, putting us above the 10 ms requirement. The wearable device of OSP has 4 cores, C0 – C3. C0 is used for all non-realtime tasks such as kernel, embedded web server, etc. and remaining cores are used for realtime tasks. Naive realization of GSC results in one or more cores not meeting the realtime constraints, resulting in audible artifacts. We present optimizations to meet time and CPU budgets; and preliminary objective and subjective results of the proposed system.
Simple, scalable mechanosynthesis of metal–organic frameworks using liquid-assisted resonant acoustic mixing (LA-RAM) (2020)

We present a rapid and readily scalable methodology for the mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assisted resonant acoustic mixing (LA-RAM) methodology for the synthesis of three- and two-dimensional MOFs based on Zn(ii), Co(ii) and Cu(ii), including a mixed ligand system. Importantly, the LA-RAM approach also allowed the synthesis of the ZIF-L framework that has never been previously obtained in a mechanochemical environment, as well as its Co(ii) analogue. Straightforward scale-up from milligrams to at least 25 grams is demonstrated using the metastable framework ZIF-L as the model.
A Dynamical State Space Representation and Performance Analysis of a Feedback-Controlled Rotary Left Ventricular Assist Device (2008)

The left ventricular assist device (LVAD) is a mechanical device that can assist an ailing heart in performing its functions. The latest generation of such devices is comprised of rotary pumps which are generally much smaller, lighter, and quieter than the conventional pulsatile pumps. The rotary pumps are controlled by varying the rotor (impeller) speed. If the patient is in a health care facility, the pump speed can be adjusted manually by a trained clinician to meet the patient's blood needs. However, an important challenge facing the increased use of these LVADs is the desire to allow the patient to return home. The development of an appropriate feedback controller for the pump speed is therefore crucial to meet this challenge. In addition to being able to adapt to changes in the patient's daily activities by automatically regulating the pump speed, the controller must also be able to prevent the occurrence of excessive pumping (known as suction) which may cause collapse of the ventricle. In this paper we will discuss some theoretical and practical issues associated with the development of such a controller. As a first step, we present and validate a state-space mathematical model, based on a nonlinear equivalent circuit flow model, which represents the interaction of the pump with the left ventricle of the heart. The associated model is a six-dimensional vector of time varying nonlinear differential equations. The time variation occurs over four consecutive intervals representing the contraction, ejection, relaxation, and filling phases of the left ventricle. The pump in the model is represented by a nonlinear differential equation which relates the pump rotational speed and the pump flow to the pressure difference across the pump. Using this model, we discuss a feedback controller which adjusts the pump speed based on the slope of the minimum pump flow signal, which is one of the model state variables that can be measured. The objective of the controller is to increase the speed until the envelope of the minimum pump flow signal reaches an extreme point and maintain it afterwards. Simulation results using the model equipped with this feedback controller are presented for two different scenarios of patient activities. Performance of the controller when measurement noise is added to the pump flow signal is also investigated.
Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine (2018)

A foot-and-mouth disease (FMD) recombinant subunit vaccine formulated with a lipid/polymer adjuvant was evaluated in two vaccine efficacy challenge studies in steers. The vaccine active ingredient is a replication-deficient human adenovirus serotype 5 vector encoding the FMD virus (FMDV) A24/Cruzeiro/BRA/55 capsid (AdtA24). In the first study, AdtA24 formulated in ENABL® adjuvant was compared to a fourfold higher dose of AdtA24 without adjuvant. Steers vaccinated with AdtA24 + ENABL® adjuvant developed a significantly higher virus neutralizing test (VNT) antibody titer and an improved clinical response following FMDV A24/Cruzeiro/BRA/55 intradermal lingual challenge at 14 days post-vaccination (dpv) than steers vaccinated with the active ingredient alone. In the second study, vaccination with AdtA24 formulated in ENABL® at the same dose used in the first study, followed by FMDV A24/Cruzeiro/BRA/55 challenge on 7 or 14 dpv, prevented clinical FMD in all steers and conferred 90% protection against viremia. In addition, post-challenge FMDV titers in nasal samples from vaccinated steers compared to unvaccinated steers were significantly reduced. In both studies, none of the AdtA24 vaccinated steers developed antibodies to the FMDV non-structural proteins prior to challenge with FMDV, indicative of the capacity to differentiate infected from vaccinated animals (DIVA). These results demonstrate that administration of AdtA24 formulated in ENABL® adjuvant lowered the protective dose and prevented clinical FMD following exposure of vaccinated steers to virulent FMDV at 7 or 14 dpv.
Grating-based tomography of human tissues (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bert Müller, Georg Schulz, Andrea Mehlin, Julia Herzen, Sabrina Lang, Margaret Holme, Irene Zanette, Simone Hieber, Hans Deyhle, Felix Beckmann, Franz Pfeiffer, Timm Weitkamp; Grating-based tomography of human tissues. AIP Conference Proceedings 31 July 2012; 1466 (1): 107–112. https://doi.org/10.1063/1.4742277 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
“Dormant” Pulmonary Vein Conduction Revealed by Adenosine after Ostial Radiofrequency Catheter Ablation (2004)

Adenosine induces transient conduction in 25% of PVs following successful isolation. Further studies are necessary to determine the physiologic or pathophysiologic role of adenosine-induced reconduction in human hearts or other organ systems.
Delocalization corrections using a disordered structure for atom location by channelling-enhanced microanalysis in the Ni-Al system (1993)

Abstract A correction procedure for the delocalization effect when determining the site occupancy of an impurity element by atom location by channelling-enhanced microanalysis is proposed. The procedure utilizes a disordered structure with a composition similar to the ordered structure. Correction factors are derived by illuminating a sample with a disordered structure in the same orientation as for the ordered structure. The correction procedure is applied to a determination of the Ti occupancy in a Ni3Al intermetallic compound.
Functional interactions of IL2 and TNF in the differentiation of LGL into lak effectors (1989)

We have previously reported on the synergistic effect of IL2 and TNF on the differentiation of LGL into LAK effectors. In the present study, we have further investigated the molecular basis of this synergistic mechanism and examined the role of TNF in the induction of LAK activity. We show that the generation of optimal LAK activity by low doses of IL-2 in the presence of TNF involves the induction of high-affinity IL2 receptors on LGL and occurs without promoting significant proliferation, suggesting a functional activation rather than a proliferative expansion of LAK precursors. Using blocking studies with anti-Tac and with an anti-IL2 (IHII), which specifically inhibits the binding of IL2 to the p75 IL2 receptor component, we also show that both the p55 and the p75 are involved in the increase in TNF binding sites on LGL and the subsequent acquisition of LAK activity. We also demonstrate that the failure of low doses of IL2 to induce LAK activity is related to their incapacity to induce TNF production. Moreover, when specific antibodies against TNF were added to the culture, the differentiation of LGL into LAK effectors by optimal concentrations of IL2 in our system (2.5-5.0 ng/ml) was partially inhibited. This suggests that TNF may be a physiologic mediator in the sequential activation stages of LGL into LAK effectors.
Image method for the derivation of point sources in elastostatic problems with plane interfaces (1986)

An image method algorithm is presented for the derivation of point sources of elastostatics in multilayered media assuming the infinite space point source is known. Specific cases were worked out and shown to coincide with well known solutions in the literature.
Multichannel Mars Organic Analyzer (McMOA): Microfluidic Networks for the Auto- mated in Situ Microchip Electrophoretic Analysis of Organic Biomarkers on Mars. Thomas (2010)

Introduction: Previously, our group created the Mars Organic Analyzer (MOA), a single channel portable instrument that was successfully field tested in the Panoche Valley, CA, and in the Atacama Desert, Chile, where it detected trace amines and amino acids using fluorescamine as the derivatization reagent. Recent work has extended the MOA’s capabilities to perform analysis of polycyclic aromatic hydrocarbons (PAHs) at ppb levels. Through use of a highly fluorescent amine reactive probe, Pacific Blue Succinimimdyl Ester, PB, our detection limits for amino acids have improved 250fold. Furthermore, the integration of PB labeling with micellar electrokinetic chromatography (MEKC) enables pseudo-2D separations, allowing for enhanced compositional analysis. Finally, recent advances in analytical protocols and buffer chemistry have improved the robustness of our CE systems and methods when analyzing highly saline and acidic samples as found in Rio Tinto sediments and Saline Valley brine samples.
Fluorescence Spectroscopic Approaches to the Study of Three-dimensional Structure of Ribosomes (1974)

INTRODUCTION Fluorescence spectroscopy has a number of attractive features for the study of a system as large and complex as the ribosome. Because fluorescent probe molecules are individually or selectively introduced, one can concentrate attention on a small portion of the whole structure. The great sensitivity of the technique means that one can conveniently work with 10 −6 –10 −7 molar solutions in sample volumes as small as 0.2 ml. At least three different kinds of information can be obtained from fluorescence studies: (1) Environmentally sensitive probes such as ethidium bromide (EB) and anilinonaphthalene sulfonate (ANS) are especially useful for monitoring conformational changes. (2) Polarization or decay of fluorescence anisotropy allow motions and flexibility to be examined. (3) Energy transfer between sets of attached fluorescent dyes enable the measurement of distances between fixed points. All of these techniques are well established and have been developed and tested on simpler biochemical systems (for recent reviews, see Steiner and Weinryb 1971; Cantor and Tao 1971; Cantor and Timasheff 1974; Stryer 1968; Brand and Gohlke 1972). A few additional complications arise when a system the size of a ribosome is involved. Here we shall examine these difficulties, survey some of the results of previous fluorescence studies on ribosomes, and attempt to chart the course of possible future studies. Choice of Fluorescent Probes All fluorescence studies demand the presence of fluorescent moieties. Their selection and specific introduction is frequently the major obstacle to meaningful experiments. The natural fluorescence of ribosomes arises principally from aromatic amino acid...
Porous ceramics for multistage Knudsen micropumps—modeling approach and experimental evaluation (2011)

This paper describes the evaluation of four types of porous ceramics for use as thermal transpiration materials in Knudsen pumps that operate at atmospheric pressure. Knudsen pumps are motionless gas pumps that utilize thermal transpiration along a channel or a set of channels; the channels must have a temperature gradient and must constrain the flow to remain within the free molecular or transitional flow regimes. Of the ceramics evaluated, a clay-based, 15 bar synthetic ceramic (15PC) presents the most favorable properties for Knudsen pumps. For an input power of 3.4 W, a 25 × 25 mm2 nine-stage Knudsen pump that uses this material provides a maximum pressure head of 12 kPa and a maximum gas flow rate of ≈3.7 µL min−1. Reliability tests demonstrate more than 11 750 h of continuous operation without any deterioration in their gas pumping capabilities. A fitted model suggests that the temporal evolution of pressure at the sealed outlet of a Knudsen pump can be captured adequately using four parameters. These parameters correspond to various nonidealities that play dominant roles in the transient response of these pumps.
Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis (2020)

We recently showed that radiation-induced DNA damage in breast adipose tissue increases autotaxin secretion, production of lysophosphatidate (LPA) and expression of LPA<sub>1/2</sub> receptors. We also established that dexamethasone decreases autotaxin production and LPA signaling in non-irradiated adipose tissue. In the present study, we showed that dexamethasone attenuated the radiation-induced increases in autotaxin activity and the concentrations of inflammatory mediators in cultured human adipose tissue. We also exposed a breast fat pad in mice to three daily 7.5 Gy fractions of X-rays. Dexamethasone attenuated radiation-induced increases in autotaxin activity in plasma and mammary adipose tissue and LPA<sub>1</sub> receptor levels in adipose tissue after 48 h. DEX treatment during five daily fractions of 7.5 Gy attenuated fibrosis by ~70% in the mammary fat pad and underlying lungs at 7 weeks after radiotherapy. This was accompanied by decreases in CXCL2, active TGF-β1, CTGF and Nrf2 at 7 weeks in adipose tissue of dexamethasone-treated mice. Autotaxin was located at the sites of fibrosis in breast tissue and in the underlying lungs. Consequently, our work supports the premise that increased autotaxin production and lysophosphatidate signaling contribute to radiotherapy-induced breast fibrosis and that dexamethasone attenuated the development of fibrosis in part by blocking this process.
Interactions between thrombin and natural products of Millettia speciosa Champ. using capillary zone electrophoresis (2008)

In Chinese medicine Suberect Spatholobus Stem is used to treat menoxenia, blood deficiency, numb paralyses, and so on. In folk, Millettia speciosa is often used as a substitute for Suberect Spatholobus Stem in some areas but it has not been reported whether M. speciosa is the eligible substitute for Suberect Spatholobus Stem or not till now. In this study, a capillary zone electrophoretic method was applied to determinate the interactions between natural products isolated from M. speciosa Champ. and thrombin for the first time. Both qualitative and quantitative characterizations of the molecule-enzyme binding were determined. Twenty ingredients were isolated from M. speciosa Champ. and the results showed that compared with positive and negative control, the compounds YT-1, YT-2, YT-3, YT-8, YT-9, YT-10, YT-11, YT-12, YT-14, YT-15, YT-16, and YT-20 interacted with thrombin while the other eight had no binding to thrombin. The binding constants of the interaction between compounds and thrombin were calculated by the Scatchard analysis formula. Because M. speciosa contains these compounds which have different levels of anticoagulant activity, it may be the eligible substitute for Suberect Spatholobus Stem.
Covariance Estimation From Compressive Measurements Using Alternating Minimization (2014)

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 2014
A micropower support vector machine based seizure detection architecture for embedded medical devices (2009)

Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG signal variability across patients. In this paper, we illustrate how a machine-learning based, patient-specific seizure detector provides better performance and lower power consumption than a patient non-specific detector using the same seizure library. The machine-learning based architecture was fully implemented in the micropower domain, demonstrating feasibility for an embedded detector in implantable systems.
A Comparison Between the HeRO Graft and Conventional Arteriovenous Grafts in Hemodialysis Patients (2014)

Venous stenosis and occlusion are a major cause of vascular access dysfunction and failure. The HeRO Graft bypasses occlusion and traverses stenosis with outflow directly into the central venous circulation. A randomized, multicenter study was conducted to evaluate the efficacy and safety of the HeRO Graft relative to conventional AV grafts. The design was to enroll 143 patients in a 2:1 randomization ratio between HeRO and conventional AV control groups. Data on 72 subjects (52 HeRO Graft and 20 AV graft controls) were obtained. The HeRO Graft and control cohorts were comparable in baseline characteristics. Adequacy of dialysis, bacteremia rates, and adverse events were consistent between groups. Twelve month Kaplan-Meier estimates for primary and secondary patency rates were 34.8% and 67.6% in the HeRO Graft cohort, and 30.6% and 58.4% in the control cohort. There was no statistical difference in terms of patency between groups. The rates of intervention were 2.2/year for HeRO Graft and 1.6/year for the control (p = 0.100). Median days to loss of secondary patency was 238 for HeRO Graft versus 102 for the control (p = 0.032). The HeRO Graft appears to provide similar patency, adequacy of dialysis, and bacteremia rates to those of conventional AV grafts.
Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor‐β2 mRNA levels in treated embryos (1994)

Abstract Retinoic acid (RA) plays an important role during normal embryogenesis, however high doses of RA are teratogenic. Retinoic acid receptor‐β2 (RAR‐β2) mRNA and protein levels were previously demonstrated to undergo rapid elevation in susceptible tissues after treatment with teratogenic doses of RA. In this report we compared the effects of a number of retinoids, which represent a wide variety of chemical structures and which differ in their teratogenic potencies, on RAR‐β2 mRNA levels in mouse embryos 6 hr after treatment. Retinoid treatments which result in a high incidence of limb defects elevated RAR‐ β2 mRNA levels similarly (10–14 fold in the limb buds, 4–8 fold in the head, and 2–4 fold in the remainder of the body). On the other hand, retinoid treatments which cause a low or no incidence of limb defects resulted in minor changes in RAR‐ β2 mRNA levels in each embryonic region. Therefore, a strong positive correlation was found between the elevation of RAR‐β2 mRNA levels and the retinoids which produce limb defects. This provides further evidence that an elevation of RAR‐β2 mRNA levels and subsequently protein levels, is an important event involved in mediating the effects of RA during dysmorphogenesis. © 1994 Wiley‐Liss, Inc.