gebhart/patrepeval huggingface dataset:
Virtual model control of a bipedal walking robot (2002)

The transformation from high level task specification to low level motion control is a fundamental issue in sensorimotor control in animals and robots. This paper describes a control scheme called virtual model control that addresses this issue. Virtual model control is a motion control language that uses simulations of imagined mechanical components to create forces, which are applied through real joint torques, thereby creating the illusion that the virtual components are connected to the robot. Due to the intuitive nature of this technique, designing a virtual model controller requires the same skills as designing the mechanism itself. A high level control system can be cascaded with the low level virtual model controller to modulate the parameters of the virtual mechanisms. Discrete commands from the high level controller would then result in fluid motion. Virtual model control has been applied to a physical bipedal walking robot. A simple algorithm utilizing a simple set of virtual components has successfully compelled the robot to walk continuously over level terrain.
Re-engineering Primary Epithelial Cells from Rhesus Monkey Parotid Glands for Use in Developing an Artificial Salivary Gland (2006)

There is no satisfactory conventional treatment for patients who experience irreversible salivary gland damage after therapeutic radiation for head and neck cancer or because of Sjo ¨gren's syndrome.Additionally, if most parenchyma is lost, these patients also are not candidates for evolving gene transfer strategies.To help such patients, several years ago we began to develop an artificial salivary gland.In the present study, we used a non-human primate tissue source, parotid glands from rhesus monkeys, to obtain potential autologous graft cells for development of a prototype device for in situ testing.Herein, we present 3 major findings.First, we show that primary cultures of rhesus parotid gland (RPG) cells are capable of attaining a polarized orientation, with Na + /K + -adenosine triphosphatase, zonula occludens-1, and claudin-1 distributed in specific domains appropriate for epithelial cells.Second, we show that RPG cells exhibit 2 essential epithelial functions required for graft cells in an artificial salivary gland device (i.e., an effective barrier to paracellular water flow and the generation of a moderate transepithelial electrical resistance).Third, we show that RPG cells can express functional water channels, capable of mediating directional fluid movement, after transduction by adenoviral and adeno-associated virus type 2 vectors.Together these results demonstrate that it is feasible to individually prepare RPG cells for eventual use in a prototype artificial salivary gland.
Activity of Granzyme A, a Serine Protease in the Killing Granules of Cytotoxic T Lymphocytes, Is Reduced in Cells from HIV-infected Hemophiliacs (1996)

Cytotoxic CD8+ lymphocytes (CTLs) kill virally infected target cells by releasing cytotoxic granules. The primary objective of this study was to determine whether the activity of granzyme A, a serine protease in the killing granules of CTLs is altered in HIV-infected hemophiliacs. A sensitive colorimetric assay that measures cleavage of a synthetic substrate, N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester (BLT), was used to quantitate granzyme A activity. Granzyme A activities from hemophiliacs were normalized to to granzyme A activities of healthy donors run concurrently. Granzyme A activity in CD8+ T cells from HIV-seropositive hemophiliacs was significantly lower than granzyme A activity in cells from HIV-seronegative hemophiliacs (0.48 units +/- 0.086/CD8+ T cell and 1.573 +/- 0.434 units/CD8+ T cell, respectively; p < 0.005). These results indicate that cytotoxic cells in HIV-infected hemophiliacs have reduced granzyme A activity, which may result in a defect in CTL-mediated cell killing in these patients.
<title>Interferometric acousto-optic receiver results</title> (1991)

This paper reports the final experimental results and conclusions on the performance of an interferometric acousto-optic receiver (IAOR). The receiver is designed to acousto-optically channelize a 1 GHz RF bandwidth spectrum into 128 frequency bins, and generate digital frequency, pulse amplitude, pulse width and TOA words. Experimental results show that the predicted performance improvement over the power acousto-optic receiver (PAOR) is significantly below expectation. Key factors contributing to performance degradation are discussed along with supporting experimental data. Recommendations for further acousto-optic receiver work are presented.
Tissue inhibitor of metalloproteinase 1 regulates matrix metalloproteinase activity during newt limb regeneration (2005)

Matrix metalloproteinase (MMP) activity is important for newt limb regeneration. In most biological processes that require MMP function, MMP activity is tightly controlled by a variety of mechanisms, including the coexpression of natural inhibitors. Here, we show that gene expression of one such inhibitor, tissue inhibitor of metalloproteinase 1 (NvTIMP1), is upregulated during the wound healing and dedifferentiation stages of regeneration when several MMPs are at their maximal expression levels. Newt MMPs and NvTIMP1 also exhibit similar spatial expression patterns during the early stages of limb regeneration. NvTIMP1 inhibits the proteolytic activity of regeneration-related newt MMPs and, like human TIMP1, can induce a weak mitogenic response in certain cell types. These results suggest that NvTIMP1 may be functioning primarily to maintain optimal levels of MMP activity during the early stages of limb regeneration, while possibly serving a secondary role as a mitogen.
Enabling Individualized Criminal Sentencing While Reducing Subjectivity: A Tablet-Based Assessment of Recidivism Risk (2016)

According to conservative estimates, the country spends a minimum of $25,500-$26,000 per year on each person incarcerated [1]. Incarceration also has long-term costs for both offenders and society. For example, a young person with a prison record may be precluded from becoming a citizen who votes, participates in community-building, and contributes to the community.
Performance Analysis of a Deep Vertical Closed-Loop Heat Exchanger through Thermal Response Test and Thermal Resistance Analysis (2016)

300 m 이상의 장심도 지중열교환기는 도심지나 넓은 부지를 확보가기 어려운 지역에 지열냉난방 시스템을 경제적으로 설치하는데 유리하다. 그러나 실제 시공에서는 여러 가지 문제들로 인하여 보편적으로 시도되지 않았고, 일반적으로 100 ~ 200m 심도로 설치되어 왔다. 본 연구에서는 일반적인 시추공 직경 150 mm에 U 파이프는 50A 규격으로 외경 50 mm의 300 m 심도로 지중열교환기를 설치하였다. 고밀도 PE관은 단위 길이당 비중이 <TEX>$0.94{\sim}0.96g/cm^3$</TEX>으로 지열공 내부에 채워진 지하수 영향으로 부력이 존재하여, 이를 개선하기 위해 4.6 kg 무게의 금속으로 제작된 하중밴드 10개조를 설치하여 부력의 영향을 감소시켰다. 지중열교환기의 길이 산정 및 성능평가를 위한 기초조사로서 지반조사 및 열응답실험이 실시되었다. 지반내 온도구배는 100 m 심도까지는 주변 지하수 이용에 의한 영향 등으로 <TEX>$15^{\circ}C$</TEX> 정도의 분포를 보이며 그 하부는 <TEX>$1.9^{\circ}C/100m$</TEX>의 지온증온율을 나타내고 있다. 열응답실험은 기존에 설정된 표준 방식으로 48 시간 진행되었으며 평균 주입전력은 17.5 kW이며 평균 순환수 유량은 28.5 l/min, 그리고 평균 입출구 온도차는 <TEX>$8.9^{\circ}C$</TEX>로 나타났다. 측정된 지중열전도도는 3.0 W/mk이며, 공내열저항은 0.104 mk/W로 나타났다. Stepwise 평가에서 지중열전도도 변화는 초기 13시간을 제외한 이후에는 표준편차가 0.16으로 매우 안정된 값으로 수렴한 것으로 나타났다. 그리고 공내열저항의 민감도를 분석한 결과 파이프의 구경과 그라우팅 물질의 열전도도가 증가함에 따라 그 값이 미미하게 감소하는 경향을 나타내었다. Due to the limited areal space for installation, borehole heat exchangers (BHEs) at depths deeper than 300 m are considered for geothermal heating and cooling in the urban area. The deep vertical closed-loop BHEs are unconventional due to the depth and the range of the typical installation depth is between 100 and 200 m in Korea. The BHE in the study consists of 50A (outer diameter 50 mm, SDR 11) PE U-tube pipe in a 150 mm diameter borehole with the depth of 300 m. In order to compensate the buoyancy caused by the low density of PE pipe (<TEX>$0.94{\sim}0.96g/cm^3$</TEX>) in the borehole filled with ground water, 10 weight band sets (4.6 kg/set) were attached to the bottom of U-tube. A thermal response test (TRT) and fundamental basic surveys on the thermophysical characteristics of the ground were conducted. Ground temperature measures around <TEX>$15^{\circ}C$</TEX> from the surface to 100 m, and the geothermal gradient represents <TEX>$1.9^{\circ}C/100m$</TEX> below 100 m. The TRT was conducted for 48 hours with 17.5 kW heat injection, 28.65 l/min at a circulation fluid flow rate indicates an average temperature difference <TEX>$8.9^{\circ}C$</TEX> between inlet and outlet circulation fluid. The estimated thermophysical parameters are 3.0 W/mk of ground thermal conductivity and 0.104 mk/W of borehole thermal resistance. In the stepwise evaluation of TRT, the ground thermal conductivity was calculated at the standard deviation of 0.16 after the initial 13 hours. The sensitivity analysis on the borehole thermal resistance was also conducted with respect to the PE pipe diameter and the thermal conductivity of backfill material. The borehole thermal resistivity slightly decreased with the increase of the two parameters.
An algorithm competition for automatic species identification from herbarium specimens (2020)

The FGVC competitions provide a unique opportunity for computer vision and machine learning experts to address difficult species-recognition problems. The Herbarium 2019 Challenge brought together a novel combination of collections resources, taxonomic expertise, and collaboration between botanists and computer scientists.
Matching-adjusted indirect treatment comparison of chimeric antigen receptor T-cell therapies for third-line or later treatment of relapsed or refractory large B-cell lymphoma: lisocabtagene maraleucel versus tisagenlecleucel (2022)

ClinicalTrials.gov identifiers: NCT02631044 and NCT02445248.
Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine (2008)

The Ret receptor tyrosine kinase is the common signaling receptor for the glial cell line-derived neurotrophic factor (GDNF) family ligands. The Met918Thr mutation leads to constitutive activation of Ret and is responsible for dominantly inherited cancer syndrome MEN2B. Previously, we found that the mice carrying the mutation (MEN2B mice) have profoundly increased tissue dopamine (DA) concentrations in the striatum as well as increased striatal levels of tyrosine hydroxylase (TH) and dopamine transporter. The aim of this study was to characterize the striatal dopaminergic neurotransmission in MEN2B mice and to clarify the mechanisms by which they compensate their over-production of DA. We found that tyrosine hydroxylase activity and DA synthesis are increased in MEN2B mice. Augmented effects of alpha-methyl-para-tyrosine (alphaMT, an inhibitor of TH) and tetrabenazine (VMAT2 blocker) on DA levels suggest that also storage of DA is increased in MEN2B mice. There was no difference in the basal extracellular DA concentrations or potassium-evoked DA release between the genotypes. The effects of cocaine and haloperidol were also similar between the genotypes as assessed by in vivo microdialysis. However, with in vivo voltammetry we found increase in stimulated DA release in MEN2B mice and detailed analysis of DA overflow showed that uptake of DA was also enhanced in MEN2B mice. Thus, our data show that enhanced synthesis of DA leading to increased storage and releasable pools in pre-synaptic terminals in MEN2B mice apparently also leads to increased DA release, which in turn is compensated by higher dopamine transporter activity.
Advancing a cultural change agenda in higher education: issues and values related to reimagining academic leadership (2022)

Traditional models of academic leadership are based largely on managerial and transactional approaches. Such efforts frequently support status quo individual success rather than values-based leadership based on collective institutional or sustainability-centered pursuits. Evolved reward systems and leaderships modes that support collective and institution-level effort and innovations prioritizing community and sustainability require new leadership models. Innovative leadership models that transcend traditional gatekeeping are needed and four leadership modes to support innovation and collective efforts are discussed, including shared leadership that draws on distributed contributions of multiple individuals; creative or innovative leadership that requires risk-taking, experimentation, and experiential learning; qualitative leadership that is data-driven and includes evidence-based innovation; and, dynamic leadership based on demonstrated agility and ability to traverse different spaces using diverse modes of doing and thinking. Progressive leaders can move in and out of these modes in response to ecosystem needs, demands, and changes through the use of design thinking and initiatives to support innovation and sustainability in higher education. Success in evolved leadership approaches, including centering sustainability goals that impact institutions themselves and communities in which they exist, require aligning reformed leadership goals and practices with funding models and reward systems, as well as policies and institutional change strategies.
평지와 오르막경사의 트레드밀 걷기와 달리기 동안 발보장구가 발바닥근막염과 관련된 발아치 스트레인에 미치는 영향 (2005)

S. J. KIM, D. Stefanyshyn, R. B. KIM. Effects of Foot Orthotics on the Foot Arch Strain related to PIantar Fasciitis During Treadmill Level and Uphill Walking and Running. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 155-176, 2005. There is some evidence that one of major factors to produce plantar fasciitis depends on the magnitude of the foot arch strain. The orthotics that can reduce the foot arch strain during locomotion may be effective to prevent or treat plantar fasciitis. Therefore, the purpose of this study was to investigate the effect of control condition and three types of foot orthotics on 3-dimensional foot arch strain that can produce plantar fasciitis during treadmill level and uphill walking and running. Sixteen male subjects are recruited and the arch length and height strain according to three types of foot orthotics with respect to control condition were measured by using two digital video cameras. The first hypothesis which the comfort of foot orthotics would be increased from arch pad, half length orthotics to full length orthotics was mostly accepted. It suggested that the types of the foot orthotics could be properly prescribed according foot regions that is pain or abnormal. The second hypothesis which the foot arch strain can be reduced by foot orthotics during level heel-toe walking and running and the third hypothesis which the foot arch strain can be reduced by foot orthotics during uphill heel-toe walking and running were rejected. The foot arch length and height strain during walking and running showed small and subject-specific characteristics and could not be optimal biomechanical variable to prove the overall comfort. The forth hypothesis which the foot arch strain cannot be reduced by foot orthotics during uphill toe walking and running was accepted. With the foot arch length and height strain during uphill toe walking and running the windlass mechanism suggested by Hicks can be explained successfully and excessive uphill toe walking and running can be one of cause of plantar fasciitis. The dynamic investigation on the foot arch such as walking and running should be carefully observed with integrated insights considering ligaments and foot bones as well as plantar fascia, extrinsic muscles and tendons, and intrinsic muscles and tendons.
Preparation of Glucose Oxidase Immobilized Electrode Using Electrodeposition Procedure and Its Glucose Sensor Properties (2014)

The importance of glucose determinations for the diagnosis and effective treatment of diabetes has been well recognized. Therefore, much effort has been devoted to developing an effective sensor for the continuous estimation of glucose concentration in subcutaneous tissue [1]. Miniaturization of the sensor device is an important subject, since smaller devices are less invasive, both physically and psychologically. A finer device will excite fewer pain receptors in the skin and will cause less tissue damage and less pain. However, fabrication of finer sensor request precise technique to immobilize enzyme in a specific area. Conventional methods of enzyme immobilization are covalent attachment,cross-linking, hydrogel entrapment, electropolymerized polymer entrapment, and the combination of two or more methods. Among the variety of procedure for the immobilization of enzyme, electropolymerized polymer entrapment is interesting, since the enzyme will be immobilized just at the position where the electricity was passed. Similar to this procedure, Matsumoto et al reported that the layer of enzyme can be formed on the electrode by applying a potential of 1.3 V (vs Ag/AgCl) in the enzyme solution containing a nonionic surfactant such as Triton X-100. Since the obtained enzyme layer was not stable, they formed a electropolymerized polyphenol film in order to improve the stability, which also functioned as a permselective film to eliminate the influence of electroactive species excite in the biological fluid such as ascorbic and uric acids. In this study, glucose oxidase was immobilized using electrodeposition procedure and polymer film was formed to stabilize the enzyme film. Glucose sensor properties of the obtained electrode were investigated using in vitro and in vivo measurements. 1. N. Matsumoto, X. Chen and G. S. Wilson, Anal Chem, 74, 368 (2002).
Low-power technology mapping for mixed-swing logic (2001)

Article Share on Low-power technology mapping for mixed-swing logic Authors: Rob A. Rutenbar Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PAView Profile , L. Richard Carley Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PAView Profile , Roberto Zafalon STMicroelectronics, Agrate (MI), Italy STMicroelectronics, Agrate (MI), ItalyView Profile , Nicola Dragone Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA and PDF Solutions, Desenzano (BS), Italy Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA and PDF Solutions, Desenzano (BS), ItalyView Profile Authors Info & Claims ISLPED '01: Proceedings of the 2001 international symposium on Low power electronics and designAugust 2001 Pages 291–294https://doi.org/10.1145/383082.383171Online:06 August 2001Publication History 2citation209DownloadsMetricsTotal Citations2Total Downloads209Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Rewarding Arm Activity in Infants at Risk: Feasibility of a Home-Based Program (2020)

Abstract Date Presented 03/26/20 Infants who sustain brachial plexus injury are at risk for neuromuscular and sensibility deficits contributing to prehensile dysfunction. OTs practicing in early intervention often have limited resources available to improve muscle activation. Yet our experimental program offers a solution, since infant-initiated muscle activation or arm movement will trigger a toy to move, reinforcing them to move again. If done repeatedly, this program could contribute to their recovery. Primary Author and Speaker: Susan Duff Contributing Authors: Milan Stevanovic, Jamie Berggren, Barbara Sargent, Andrew Kimbel, Cyril Rakovski, Ehsan Yaghmaei, Peter Pidcoe, Benjamin Leiby, Mitchel Seruya, Eric Wade
An Autonomous Probing System for Collecting Measurements at Depth from Small Surface Vehicles (2021)

This paper presents the portable autonomous probing system (APS), a low-cost robotic design for collecting water quality measurements at targeted depths from an autonomous surface vehicle (ASV). This system fills an important but often overlooked niche in marine sampling by enabling mobile sensor observations throughout the near-surface water column without the need for advanced underwater equipment. We present a probe delivery mechanism built with commercially available components and describe the corresponding open-source simulator and winch controller. Finally, we demonstrate the system in a field deployment and discuss design trade-offs and areas for future improvement. Project details are available on https://johannah.github.io/publication/sample-at-depth our website
IMPLICATIONS OF SKY RADIANCE ON DEEP-SPACE OPTICAL COMMUNICATION LINKS (2014)

As the number of deep-space missions that are turning to optical communications to support science operations increases, system designers are taking a more in depth look at the link budgets that govern such links. Noise sources, such as the radiance arising from scattering in the Earth’s atmosphere and light reflected from planetary bodies in close visual proximity to spacecraft, become particularly critical given the photon-starved channels normally associated with deep-space links. In the case of the Earth’s atmosphere, sky radiance becomes a significant factor when considering daytime operations especially when operators need to support spacecraft contacts close to the Sun. This paper encapsulates the implications of sky radiance on deep-space optical communication scenarios and provides an overview of the current efforts underway in Europe to further quantify its impact on future mission operations.
Dual targeted molecular imaging for atherosclerotic plaque detection (2008)

Selectins and VCAM‐1 are responsible for leukocyte adhesion in atherosclerosis and have been proposed as targets for molecular imaging of the disease. Currently, no method exists to reliably detect inflamed atherosclerotic plaque. In this study, perfluorocarbon‐filled microbubble contrast agents are coupled by a biotin‐streptavidin bridge with mAb MVCAM.A(429), a sialyl Lewis x polymer (sLe x ) or both (dual). Adhesion of these agents respectively to recombinant mouse VCAM‐1 and P‐selectin substrates was investigated in a parallel plate flow chamber at wall shear stresses between 0.5 and 4.5 dyne/cm 2 . The amount of antibody on the bubbles was determined by flow cytometry. The amount of P‐selectin and VCAM‐1 on substrates was determined with 125 I radiolabeled antibodies. Accumulation of both MVCAM.A(429) or sLe x microbubbles was higher on P‐selectin or VCAM‐1 coated substrates rather than casein blocked controls. Both dual targeted and MVCAM.A(429) microbubbles showed increased adhesion over controls. Interactions between SLe x bubbles and the substrate predominantly consisted of rolling rather than adhesion. Dual targeting can increase the binding efficiency of contrast agents to substrates that mimic inflamed endothelium, suggesting they may be useful for atherosclerotic plaque detection. Supported in part by NIH 2 R01 EB002185.