gebhart/patrepeval huggingface dataset:
A Family with Von Hippel-Lindau Disease Revealed by Pheochromocytoma. (2001)

Von Hippel-Lindau (VHL) disease is an inherited neoplastic disease characterized by a predisposition to develop retinal angiomas, central nervous system hemangioblastomas, renal cell carcinomas, pancreatic cysts and pheochromocytomas. Recently, we encountered three members of the same family who each had both VHL disease and pheochromocytoma. As in all three patients we suspected pheochromocytoma, the diagnosis of VHL disease should be considered. The possible presence of VHL disease was initially investigated in all three patients based on the presence of pheochromocytoma. A mutational analysis of the VHL gene revealed the presence of a missense mutation, consisting of a G to A transversion, at nucleotide 713 in all three patients. This germline point mutation in the VHL gene is often detected in type 2 VHL disease with pheochromocytoma. Genetic analysis seems to be useful for early detection of VHL disease, even when the formal criteria for diagnosis of this disease are lacking.
Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5. (1978)

The gene for the receptor for ecotropic murine leukemia virus (Rev) has been assigned to mouse chromosome 5. This determination was made possible by an analysis of somatic cell hybrids between mouse and Chinese hamster cells. The parents of these hybrids were A/HeJ or Mus poschiavinus peritoneal exudate cells or BALB/c primary embryo fibroblasts and E36, a Chinese hamster lung fibroblast deficient in hypoxanthine guanine phosphoribosyltransferase. Segregation of mouse chromosomes in these hybrids was analyzed by chromosome banding and isozyme expression. Cells were tested for their ability to absorb and replicate vesicular stomatitis virus (murine leukemia virus [MuLV]) pseudotype particles and ecotropic MuLV as measured by the XC test. The presence of chromosome 5 was essential for receptor expression as determined by three statistical procedures. Segregation of the receptor for ecotropic murine leukemia virus was also followed in two series of subclones. In both, receptor expression was syntenic with phosphoglucomutase-1, an isozyme which has been mapped to mouse chromosome 5.
High Levels of Hydrogen Peroxide in Overnight Tooth-Whitening Formulas: Effects on Enamel and Pulp (2005)

Overnight tray products containing levels of hydrogen peroxide of 3.5%, 7.0%, and 12.0% are not expected to adversely affect the enamel or pulpal enzymes. Additional safety studies are needed to assess the potential for tooth sensitivity and gingival irritation.
Network as a resource: G-lambda project and its architecture (2007)

In computing systems, hardware components such as CPUs, memories and storages are “resources”. Resources are managed by resource managers (c.f. a queuing system of a computing center), and a user can use them while they are allocated to the user. To provide a stable service using “resources” connect
Photovoltaic (PV) cells characterization using advanced optical tools (2010)

In this paper we investigate the use of advanced imaging characterization tools for photovoltaic (PV) cell characterization. These tools were originally developed for CMOS VLSI circuits and offer very high sensitivity and spatial resolution. Optical imaging of PV cells using different tools and techniques will be compared and discussed.
Altered metabolic gene expression in the brain of a triprolyl-human amylin transgenic mouse model of type 2 diabetes (2019)

Type 2 diabetes mellitus is a major health concern worldwide; however, the molecular mechanism underlying its development is poorly understood. The hormone amylin is postulated to be involved, as human amylin forms amyloid in the pancreases of diabetic patients, and oligomers have been shown to be cytotoxic to β-cells. As rodent amylin is non-amyloidogenic, mice expressing human amylin have been developed to investigate this hypothesis. However, it is not possible to differentiate the effects of amylin overexpression from β-cell loss in these models. We have developed transgenic mice that overexpress [<sup>25, 28, 29</sup> triprolyl]human amylin, a non-amyloidogenic variant of amylin, designated the Line 44 model. This model allows us to investigate the effects of chronic overexpression of non-cytotoxic amylin. We characterised this model and found it developed obesity, hyperglycaemia and hyperinsulinaemia. This phenotype was associated with alterations in the expression of genes involved in the amylin, insulin and leptin signalling pathways within the brain. This included genes such as c-Fos (a marker of amylin activation); Socs3 (a leptin inhibitor); and Cart, Pomc and Npy (neuropeptides that control appetite). We also examined Socs3 protein expression and phosphorylated Stat3 to determine if changes at the mRNA level would be reflected at the protein level.
Local Deformation Energy and Void Formation Behavior in 16%Cr Ferritic Steel (2012)

Tensile tests of 16mass%Cr bearing ferritic steels were performed in order to investigate the effect of the mean interparticle spacing (λ) on the local deformation energy. λ of Cr precipitates was changed from 3.3 to 5.1 μm. The amounts of Cr precipitates in the specimens tested were controlled to be the same level.The local deformation energy was increased with increasing λ in the specimens without a notch, while the local deformation energy does not depend on λ for the notched specimens.AsB (Angle selective Backscattered Electron Detector) images of voids beneath the fracture surface showed that the difference of the local deformation energy dependence on λ between notchless and notched specimens was due to the void coalescence processes. This finding reveals that the local deformation energy is influenced by the stress triaxiality through the void coalescence behavior.
Technology Options for Improved Air Vehicle Fuel Efficiency: Executive Summary and Annotated Brief (2006)

As crude oil prices and worldwide competition for fuel continue to increase, there are added pressures on the United States to simultaneously conserve fuel as well as seek new sources of energy for power generation and transportation systems. Within the U.S. military, increasing costs of fuel directly affect the ability to carry out military missions. Hence it is imperative that the Department of Defense, and the Air Force in particular (as the largest consumer of fuel within the DoD), explore ways in which improved fuel efficiency as well as alternative sources of fuel may be realized. The Air Force Scientific Advisory Board was thus tasked by the Air Force leadership to perform a quick look study exploring potential scientific and technological solutions that could impact energy and fuel efficiency. This report, consisting of an executive summary and annotated briefing with an elaboration of additional promising technologies (Appendix E), is intended to provide a complete discussion on the background, issues, findings, and recommendations from the study, which focused primarily on air vehicles.
Supplementary Methods, Supplementary Figure 1-8, Supplementary Table 1 from The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma (2023)

&lt;p&gt;Supplementary Methods: Fluorescence in situ hybridization (FISH); MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) enzymatic conversion assay; Western blot analysis; Multiparametric flow cytometry; Table S1. List of the antibodies used for multiparametric flow cytometry; Degranulation assay; Proliferation assay; Cytotoxicity assays; Cytokine measurements; Animal experiments; Figure S1. Different sensitivity to ibrutinib in hematological cell lines; Figure S2. MCL-RL engrafted mice: tumor burden and histology; Figure S3. CTL019 design and production; Figure S4. CTL019 cell production from primary MCL samples; Figure S5. Effect of ibrutinib in T cell function in vitro and in vivo; Figure S5. Effect of ibrutinib in T cell function in vitro and in vivo. A. CTL019 proliferation assay in the presence of ibrutinib;Figure S6. Peripheral blood T cell subsets in mice treated with CART19 or CART19-ibrutinib; Figure S7. CXCR4 and inhibitory/costimulatory receptor expression in peripheral blood of mice treated with CART19 or CART19-ibrutinib; Figure S8. A. Ibrutinib did not enhance the anti-tumor activity of control untransduced T cells.&lt;/p&gt;
Uptake of Toxic Metal Ions from Water by Naked and Monolayer Protected Silver Nanoparticles: An X-ray Photoelectron Spectroscopic Investigation (2010)

We have studied the chemical interaction of heavy metal ions such as Hg(II), Hg(I), Pb(II), and Cd(II) of various concentrations with naked and protected silver nanoparticles (Ag@citrate and Ag@MSA, respectively, where MSA is mercaptosuccinic acid). The particles were of 30 and 8 nm diameter, respectively. We observed that the metal ions interact with both the core of the nanoparticles and the functional groups of the capping agents. We study the effects of interaction using spectroscopic and microscopic techniques such as ultraviolet−visible spectroscopy (UV−vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and in detail by X-ray photoelectron spectroscopy (XPS). The Hg(II) and Hg(I) ions were reduced to metallic mercury by both of the nanoparticles, because of the feasibility of the redox reaction, whereas no reduction was observed for Cd(II) and Pb(II). The reduction of Hg(I) and Hg(II) ions was due to electrons supplied by the core silver atoms of the nanoparticles, at lower metal ion concentrations. At higher concentrations, the metal ions were chemically bonded to the carboxylate groups of the citrate and MSA. These heavy metal ions form stable sulfides. The presence of different sulfur species, such as oxidized sulfur, disulfides, and metal sulfides, was confirmed by XPS.
Photoluminescent Properties of AlAs/AlxGa1-xAs (x=0.5) Disordered Superlattices (1990)

The AlAs/Al 0.5 Ga 0.5 As disordered superlattice is fabricated, and its photoluminescent properties are compared with those of Al 0.76 Ga 0.24 As bulk alloy and the (AlAs) 2 (Al 0.5 Ga 0.5 As) 2 ordered superlattice. Their macroscopic AlAs compositions are almost the same, 0.75, but their microscopic structures are different. Among them, the AlAs/Al 0.5 Ga 0.5 As disordered superlattice exhibits the highest photoluminescent intensity at 4.2 K. A red shift is observed in a photoluminescent peak.
Construction of 2,3- and 3,4-Functionalized Silacyclopentanes: Synthesis of 6-Aza-2,2-Diphenyl-2-Silabicyclo[3.1.0]Hexane and 6-Aza-3,3-Diphenyl-3-Silabicyclo[3.1.0]Hexane Derivatives (1998)

Abstract The synthesis of five azasilabicyclo[3.1.0]hexanes containing an aziridine function in the α- or the β- position of the silicon atom is described. These bicyclic heterocompounds differ by the various substituents (H, Me, CO2Et, CPh3) on the nitrogen atom.
Coalescence of drops with mobile interfaces in a quiescent fluid (2013)

Abstract A study on the axisymmetric near-contact motion of drops with tangentially mobile interfaces under the action of a body force in a quiescent fluid is described. A long-time asymptotic analysis is presented for small-deformation conditions. Under these conditions the drops are nearly spherical, except in the near-contact region, where a flattened thin film forms. According to our analysis, a hydrostatic dome does not form in the near-contact region at long times, in contrast to the assumption underlying all previous analyses of this problem. Instead, the shape of the film in the near-contact region results from the absence of tangential stresses acting on it. As a result, the long-time behaviour of the system is qualitatively different than previously predicted. According to the theory presented herein, the minimum film thickness (rim region) decays with time as ${h}_{m} \sim {t}^{- 4/ 5} $ , and the thickness at the centre of the film decays as ${h}_{0} \sim {t}^{- 3/ 5} $ , which is a faster decay than predicted by prior analyses based on a hydrostatic dome. Numerical thin-film simulations quantitatively confirm the predictions of our small-deformation theory. Boundary-integral simulations of the full two-drop problem suggest that the theory also describes qualitatively the long-time evolution under finite-deformation conditions.
Cavity Optomechanics with Suspended Carbon Nanotubes (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Zhang, A. Barnard, P. L. McEuen, and M. Lipson, "Cavity Optomechanics with Suspended Carbon Nanotubes," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper FTu2B.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Neuroadaptive Control for Trajectory Tracking of Indirect Drive Robots (2017)

Most industrial robots are indirect drive robots, which utilize low torque and high speed motors. Indirect drive robots have gear reducers between the motors and links. Due to the flexibility of transmission units, it is difficult to achieve high accuracy for trajectory tracking. In this paper, a neuroadaptive control, which is essentially a neural network (NN) based adaptive back-stepping control approach, is proposed to deal with this problem. The stability of the proposed approach is analysed using Lyapunov stability theory. A data-driven approach is also proposed for the training of the neural network. The effectiveness of the proposed controller is verified by simulation of both single joint and 6-axis industrial robots.
Wireless Channel Prediction in Partially Observed Environments (2022)

Site-specific radio frequency (RF) propagation pre-diction increasingly relies on models built from visual data such as cameras and LIDAR sensors. When operating in dynamic settings, the environment may only be partially observed. This paper introduces a method to extract statistical channel models, given partial observations of the surrounding environment. We propose a simple heuristic algorithm that performs ray tracing on the partial environment and then uses machine-learning trained predictors to estimate the channel and its uncertainty from features extracted from the partial ray tracing results. It is shown that the proposed method can interpolate between fully statistical models when no partial information is available and fully deterministic models when the environment is completely observed. The method can also capture the degree of uncertainty of the propagation predictions depending on the amount of region that has been explored. The methodology is demonstrated in a robotic navigation application simulated on a set of indoor maps with detailed models constructed using state-of-the-art navigation, simultaneous localization and mapping (SLAM), and computer vision methods.
Clinical guidelines for oral appliance therapy in the treatment of snoring and obstructive sleep apnoea (2013)

The purpose of this review is to provide guidelines for the use of oral appliances (OAs) for the treatment of snoring and obstructive sleep apnoea (OSA) in Australia. A review of the scientific literature up to June 2012 regarding the clinical use of OAs in the treatment of snoring and OSA was undertaken by a dental and medical sleep specialists team consisting of respiratory sleep physicians, an otolaryngologist, orthodontist, oral and maxillofacial surgeon and an oral medicine specialist. The recommendations are based on the most recent evidence from studies obtained from peer reviewed literature. Oral appliances can be an effective therapeutic option for the treatment of snoring and OSA across a broad range of disease severity. However, the response to therapy is variable. While a significant proportion of subjects have a near complete control of the apnoea and snoring when using an OA, a significant proportion do not respond, and others show a partial response. Measurements of baseline and treatment success should ideally be undertaken. A coordinated team approach between medical practitioner and dentist should be fostered to enhance treatment outcomes. Ongoing patient follow-up to monitor treatment efficacy, OA comfort and side effects are cardinal to long-term treatment success and OA compliance.
Components of fog computing in an industrial internet of things context (2015)

The "Internet of Things" (IoT) represents an em- bodiment of the continuous convergence between the physical facet of human activities and its reflection on the informa- tion world. In the context of “Industrial Internet”, where the operation of complex physical machinery is integrated with networked sensors and software applications, IoT is under- stood as a technological enabler of significant advances in the efficiency of industrial processes. In this paper, we elaborate on the main challenges brought on by the Industrial Internet and identify its key enabling technologies relevant to the Fog Computing paradigm. Further on, we propose the introduction of an Adaptive Operations Platform (AOP) to provide end-to- end manageability of the enabling Fog Computing infrastructure according to the operational requirements of industrial process. We present our prototype setup for AOP and elaborate on its performance evaluation in a typical industrial scenario.
Synthesis and Thermolysis of Heterocyclic 3-Aza-3-ene-1,5-diynes1 (2002)

[reaction: see text] Simple, acyclic 3-aza-3-ene-1,5-diynes undergo an aza-Bergman rearrangement to a fleeting 2,5-didehydropyridine (2,5-ddp) intermediate that rapidly ring-opens to beta-alkynylacrylonitrile products. In an effort to access longer-lived 2,5-ddp intermediates, we have prepared heterocyclic 3-aza-3-ene-1,5-diynes. The thermolysis of one such heterocyclic aza-enediyne does not afford products derived from trapping a 2,5-ddp intermediate but rather cyclopropanes that appear to arise from a carbene intermediate and a product that appears to be a trapping product from a 2,3-ddp intermediate.
21211 Study on mechanism of polishing pad surface dressing (2013)

In order to clarify the phenomenon and effect upon the dresser to refresh the polishing pad surface in CMP process. A single point dressing processing on the surface of the polishing pad with a diamond bite was observed by a high-speed camera. Machining scar can be seen on the edge portion of the pore on the polishing pad surface. Deformation of the polishing pad surface was also observed with a microscope
Subspace based low rank and joint sparse matrix recovery (2014)

We consider the recovery of a low rank and jointly sparse matrix from under sampled measurements of its columns. This problem is highly relevant in the recovery of dynamic MRI data with high spatio-temporal resolution, where each column of the matrix corresponds to a frame in the image time series; the matrix is highly low-rank since the frames are highly correlated. Similarly the non-zero locations of the matrix in appropriate transform/frame domains (e.g. wavelet, gradient) are roughly the same in different frame. The superset of the support can be safely assumed to be jointly sparse. Unlike the classical multiple measurement vector (MMV) setup that measures all the snapshots using the same matrix, we consider each snapshot to be measured using a different measurement matrix. We show that this approach reduces the total number of measurements, especially when the rank of the matrix is much smaller than than its sparsity. Our experiments in the context of dynamic imaging shows that this approach is very useful in realizing free breathing cardiac MRI.
Induction of immune tolerance toward tumor‐associated‐antigens enables growth of human hepatoma in mice (2001)

Adoptive transfer of immunity against hepatitis B surface antigen (HBsAg) was previously shown to facilitate suppression of experimental human hepatocellular carcinoma (HCC) expressing HBsAg in athymic mice. We have shown that oral tolerance induces antigen-specific immune suppression of HBsAg by feeding hepatitis B virus (HBV) antigens. In the present study we evaluated the effect of oral tolerance induction toward HBV or HCC antigens on the growth of experimental HCC-expressing HBsAg in mice. Tolerance induction was induced in mice by 5 oral feedings of 1 microg HBV antigens or HCC-extracted proteins (50 microg protein) before vaccination with recombinant HBsAg. Splenocytes (2 x 10(6)) from these mice were transferred to sublethally irradiated athymic BALB/c mice previously transplanted subcutaneously with 10(7) human hepatoma Hep3B cells. Adoptive transfer of splenocytes immunized toward HBsAg prevented tumor growth. At 4 weeks after splenocyte transplantation, tumor volume and serum alpha-fetoprotein (AFP) levels in athymic mice transplanted with splenocytes immunized to HBsAg were undetectable as compared with 1,048 +/- 738 mm(3) and 2,500 +/- 1,431 ng/ml in recipients of naïve splenocytes (p < 0.0001). Mice receiving splenocytes tolerized toward Hep3B cells, as manifested by reduced serum HBs antibody levels, reduced HBV-specific stimulation index and reduced HBV-specific-IFN gamma spot-forming cells, had early tumor growth evident by elevated AFP serum levels, weight loss and mortality, which were suppressed at 6 weeks. Mice transplanted with splenocytes tolerized toward HBV antigens did not have direct evidence of tumor growth. Induction of oral tolerance toward HCC-extracted proteins enabled transient tumor growth in this model. This effect was mediated through downregulation of the anti-HBV immune response.
Watt-level 2150 nm fiber laser (2022)

We report on two architectures for obtaining watt-level single mode output from a fiber laser at 2150 nm, one based on a diode-pumped Thulium fiber laser, and another based on a Thulium fiber laser pumped Holmium fiber laser. We observe temporal instability in the diode-pumped Tm-doped fiber system when operating at 2150 nm, with unstable pulsing, and a maximum power of 0.935 W. The Ho-doped fiber system pumped by Tm laser operating at the same 2150 nm wavelength shows periodic pulsing at a fixed rate of 21.25 MHz. Pulsing was observed as soon as the laser threshold was reached. Both laser systems operated in a single spatial mode.
Analysis of Embedded-Diode Performance in MOSFET under Switching Condition (2019)

It has been measured that the I-V characteristics of the embedded diode in SiC MOSFETs shows an unexpected V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gs</sub> dependence. With the use of 2D-device simulation, we have analyzed the reason for this phenomenon. It was found that a non-negligible bipolar effect is the origin. Further, a compact model has been developed to reproduce the measured V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gs</sub> dependence. The model enables the prediction of this unexpected V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gs</sub> dependence based on the device's structural features.