gebhart/patrepeval huggingface dataset:
Synthetic Aperture Radar Image Geolocation Using Fiducial Images (2022)

Synthetic Aperture Radar (SAR) creates imagery of the earth?s surface from airborne or spaceborne radar platforms. However, the nature of any radar is to geolocate its echo data, i.e., SAR images, relative to its own measured radar location. Acceptable accuracy and precision of such geolocation can be quite di fficult to achieve, and is limite d by any number of parameters. However, databases of geolocated earth imagery do exist, often using other imaging modalities, with Google Earth being one such example. Thes e can often be much more accurate than what might be achievable by the radar itself. Cons equently, SAR images may be aligned to some higher accuracy database, there by improving the geolocation of features in the SAR image. Examples offer anecdotal evidence of the viability of such an approach. - 4 - Acknowledgements This report is the result of an unf unded Research and Development effort. A special thank you to Tommy Burks for his da ta collections in the Albuquerque area.
The pathophysiology of diastolic heart failure (2010)

Whilst resting disturbances of both diastolic and long-axis systolic function are observed in patients with heart failure who have normal left ventricular ejection fraction, recent evidence suggests that dynamic disturbances in cardiac function occur during exercise. A paradoxical slowing of left ventricular active relaxation during exercise limits cardiac filling and therefore stroke volume and appears to be due to the combination of cardiac energetic impairment and disturbed ventricular-vascular coupling.
Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway (2017)

Gastric cancer is one of the most common cancers in Asian countries. Searching for reliable biomarkers involving the development of gastric cancer is important for clinical practice. Quantitative proteomics has become an important method contributed to the discovery of novel diagnostic or therapeutic targets for the management of cancer. Here, we identified differently expressed proteins in gastric cancer and normal gastric tissues by using the high resolution mass spectrometer. Among the total of 2280 identified proteins, 87 were differentially expressed between gastric cancer and normal gastric tissues. Notably, several significant proteins are in the PDGF-B signaling pathway, including peroxiredoxin5 (PRDX5), S100A6, calreticulin (CALR) and cathepsin D (CTSD), which were validated by western blot. Furthermore, upstream regulators including PDGF-B, PDGFR-β, Akt, eIF4E and p70s6K were found significantly increased in the gastric cancer tissues. In addition, silencing of PRDX5 and PDGF-B suppressed the proliferation of gastric cancer cells in vitro. The administration of exogenous PDGF-BB recovered the reduced expression of PDGF-B signaling pathway in PDGF-B knockdown cells. Taken together, our findings suggested that PDGF-B signaling pathway plays an important role in the regulation of gastric cancer proliferation and the inhibition of this pathway may be a potential approach for treatment of gastric cancer.
Interpretation of cerebrospinal fluid protein tests in the diagnosis of sporadic Creutzfeldt–Jakob disease: an evidence-based approach (2014)

Prion diseases are rare, lethal, untreatable degenerative brain disorders of humans and animals. They are linked to conversion of a specific brain protein from its normal form (PrPC) into a misfolded, pathologic form (PrPSc) and are transmissible between individuals by a novel protein-based
Recurrent NEAT Assisted 2D-DOA Estimation With Reduced Complexity for Satellite Communication Systems (2022)

Direction-of-arrival (DOA) estimation plays a vital role in the field of array signal processing. However, the need for heavy computing tasks in most traditional DOA algorithms, e.g., multiple signal classification (MUSIC), makes their engineering practicality significantly compromised in satellite communication systems. The neuroevolution of augmenting topologies (NEAT) can quickly search for appropriate topologies and weights of neural network functions, but its computational complexity is still too high for satellite systems. This paper proposes a modified NEAT architecture featuring a recurrent structure (RNEAT) that only needs a small number of phase components of the received signal covariance matrix as inputs to reduce the complexity and simplify the neural network architecture. The proposed RNEAT incorporated with multiple signal classification (RNEAT-MUSIC) features low complexity to achieve high resolution and low complexity simultaneously. Validation has been done by applying the proposed method in a two-dimensional direction of arrival estimation (2D-DOA) problem. Results show that the proposed RNEAT-MUSIC efficiently restricts the scanning region before forwarding the covariance matrix to the MUSIC stage. Consequently, the computational workload is reduced by 3/4 compared with the traditional 2D-MUSIC algorithm while maintaining satisfactory DOA resolution.
Models for Inelastic Deformation of Particles Associated With Hot Pressing of Metal Matrix Composites (1992)

During fabrication of fiber reinforced metal-matrix composites by hot pressing, fiber breakage due to particles impingement during consolidation of fiber/particle system is very common. In studying the fiber breakage, one of the main issues is the interactions between fibers and particles during consolidation. In this study, we proposed to investigate the problem of fiber/particle interactions by examining a unit problem consisting of a deformable particle and a cylinder. A rather engineering model for axisymmetric deformation of a particle induced by a rigid sphere was developed first and then extended to the interactions between a deformable particle and a rigid cylinder. The calculations were compared with experiments on lead balls, good agreement was observed. The model was then applied to determining the maximum bending stress in fibers using the simple beam theory. A safe criterion for preventing fibers from breaking was found.
Peyer's patches are required for oral tolerance to proteins (2001)

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin beta-receptor Ig fusion protein to generate mice lacking Peyer's patches. When these Peyer's patch-null mice were fed 25 mg of ovalbumin (OVA) before systemic immunization, OVA-specific IgG Ab responses in serum and spleen were seen, in marked contrast to low responses in OVA-fed normal mice. Further, high T-cell-proliferative- and delayed-type hypersensitivity responses were seen in Peyer's patch-null mice given oral OVA before systemic challenge. Higher levels of CD4(+) T-cell-derived IFN-gamma, IL-4, IL-5, and IL-10 syntheses were noted in Peyer's patch-null mice fed OVA, whereas OVA-fed normal mice had suppressed cytokine levels. In contrast, oral administration of trinitrobenzene sulfonic acid (TNBS) to Peyer's patch-null mice resulted in reduced TNBS-specific serum Abs and splenic B cell antitrinitrophenyl Ab-forming cell responses after skin painting with picryl chloride. Further, when delayed-type hypersensitivity and splenic T cell proliferative responses were examined, Peyer's patch-null mice fed TNBS were unresponsive to hapten. Peyer's patch-null mice fed trinitrophenyl-OVA failed to induce systemic unresponsiveness to hapten or protein. These findings show that organized Peyer's patches are required for oral tolerance to proteins, whereas haptens elicit systemic unresponsiveness via the intestinal epithelial cell barrier.
Quantifying leakage fields at ionic grain boundaries using off-axis electron holography (2020)

The electrical properties of interfaces in semiconductors and ionic conductors are immensely important in a wide range of applications. Electron holography is ideally suited for the direct measurement of the electrostatic potential of such interfaces. A key challenge with this approach is the contribution of the leakage field from the sample to the observed electron phase shift. This leakage field cannot be a priori independently determined and can cause an overestimation of the phase shift. In this work, we use finite element simulations to compute the three-dimensional electrostatic potential in the vicinity of an interface associated with a given interfacial charge density distribution. We then evaluate the predicted phase shift and demonstrate that the leakage field strongly affects the recovery of the projected interface potential. From the difference between the true potential and uncorrected, recovered potential, we propose a method to correct for this effect. We then demonstrate the application of this methodology to the analysis of experimental off-axis electron holography data acquired from the grain boundaries in lightly doped ceria.
Determination of complex permittivity for low- and high-loss materials at microwave frequencies (2014)

We present the determination of the complex permittivity for low loss PCB material FR4 and high loss arsenic-doped silicon wafer in the GHz frequency range, based on closed-form analytical expressions employing the Bessel's functions. For convenience and economical reasons, the FR4 sample is cut from the commercial PCB as a sandwich disk of copper-dielectric-copper, while the bare silicon disk is contained in a prefabricated conducing cavity, referred to as the radial line cavity. Experimental measurements in support with the numerical analysis are also presented. Good agreement between computational results and laboratory measured data is observed.
Moorella humiferrea sp. nov., a thermophilic, anaerobic bacterium capable of growth via electron shuttling between humic acid and Fe(III) (2011)

An anaerobic, thermophilic, spore-forming bacterium (strain 64-FGQ(T)) was isolated from a terrestrial hydrothermal spring from the Kamchatka peninsula, Russia. This strain utilized lactate as an electron donor, insoluble poorly crystalline Fe(III) oxide incorporated into alginate beads as a potential electron acceptor and 9,10-anthraquinone-2,6-disulfonate (AQDS) as an electron-shuttling compound. Vegetative cells of strain 64-FGQ(T) were Gram-stain-positive, peritrichously flagellated, motile, straight rods, 0.3-0.5 µm in diameter and 2.0-5.0 µm long, growing singly or forming short chains. Cells formed round refractive endospores in terminal swollen sporangia. The temperature range for growth was 46-70 °C, with an optimum at 65 °C. The pH range for growth was 5.5-8.5, with an optimum at pH 7.0. The substrates utilized by strain 64-FGQ(T) in the presence of AQDS as an electron acceptor included lactate, malate, succinate, glycerol and yeast extract. The strain fermented galactose, fructose, maltose, sucrose, pyruvate and peptone. Strain 64-FGQ(T) used AQDS, humic acid, thiosulfate, nitrate and perchlorate as electron acceptors for growth. Fe(III) was not directly reduced, but strain 64-FGQ(T) was able to grow and reduce Fe(III) oxide in the presence of small amounts of AQDS or humic acid as electron-shuttling compounds. The G+C content of the DNA of strain 64-FGQ(T) was 51 mol%. 16S rRNA gene sequence analysis placed the isolate in the genus Moorella, with the type strain of Moorella glycerini as its closest relative (97.2% similarity). Based on phylogenetic analysis and physiological characteristics, strain 64-FGQ(T) is considered to represent a novel species of the genus Moorella, for which the name Moorella humiferrea sp. nov. is proposed; the type strain is 64-FGQ(T) (=DSM 23265(T)=VKM B-2603(T)).
GUEST EDITORIAL - IP MULTIMEDIA SYSTEMS INFRASTRUCTURE AND SERVICES PART II (2007)

The eight articles in this special section focus on IP multimedia systems' infrastructure and services. While the March 2007 issue of this magazine focused on challenges at the infrastructure and service levels, these articles address additional areas such as applications, operations, and challenges in implementation and testing.
An N-terminal G11A mutation in HOXD13 causes synpolydactyly and interferes with Gli3R function during limb pre-patterning† (2012)

Synpolydactyly (SPD) is a distal limb anomaly characterized by incomplete digit separation and the presence of supernumerary digits in the syndactylous web. This phenotype has been associated with mutations in the homeodomain or polyalanine tract of the HOXD13 gene. We identified a novel mutation (G11A) in HOXD13 that is located outside the previously known domains and affects the intracellular half life of the protein. Misexpression of HOXD13(G11A) in the developing chick limb phenocopied the human SPD phenotype. Finally, we demonstrated through in vitro studies that this mutation has a destabilizing effect on GLI3R uncovering an unappreciated mechanism by which HOXD13 determines the patterning of the limb.
Combined Use of Glucose-Specific Model Identification and Alarm Strategy Based on Prediction-Funnel to Improve Online Forecasting of Hypoglycemic Events (2022)

The combined use of a glucose-specific metric and an alarm-raising strategy based on the prediction-funnel allows achieving a more effective and reliable hypoglycemia prediction algorithm.
Fair watermarking techniques (2002)

Many intellectual property protection (IPP) techniques have been proposed. Their primary objectives are providing convincible proof of authorship with least degradation of the quality of the intellectual property (IF), and achieving robustness against attacks. These are also well accepted as the most important criteria to evaluate different IPP techniques. The essence of such techniques is to limit the solution space by embedding signatures as constraints. One key issue that should be addressed but has not been discussed is the fairness of the techniques: what is the quality of the solution subspace for different signatures, that is, how large the solution subspace is (uniqueness), and how difficulty it is to get a solution from such subspace (hardness). In this paper we introduce fairness as one of the metrics for good IPP techniques and post the challenge problem. of how to design fair water-marking techniques. We claim that all fair techniques have to be instance-oriented and due to the complexity of the problem itself we propose an approach that utilizes the statistical information of the problem instance. We use the satisfiability (SAT) problem as an example to illustrate how fairness could be achieved. We make the observation that the unfairness of the previous watermarking techniques comes from the global embedding of the signature and propose fair watermarking techniques. We test the uniqueness and hardness on a model with full knowledge of the solution and real life benchmarks as well. The experimental results show fairness can be achieved.
Image Compression with Multitree Tilings. (2006)

We use the framework of multitree dictionaries (Huang et al. (2003)) to design a novel DCT-based image coder which significantly outperforms both the standard JPEG and the quadtree-based approach of Ramchandran et al. (1993).
[[3,3′‐(1,3‐Propanediyldiimino) Bis‐[3‐Methyl‐2‐Butanone]Dioximate](1–)‐ N,N′,N″,N″′ ]Nickel(II), Nioyl (1996)

This chapter contains sections titled: 3,3′-(1,3-Propanediyldiimino)bis[3-methyl-2-butanone]-dioxime, PnAo 3,3′-(1,3-Propanediyldiimino)Bis[3-Methyl-2-Butanone]-oximate](1-)-N,N′,N″N″′]nickel(II),Nioyl
An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model (2017)

Fungal <i>Candida</i> species are commensals present in the mammalian skin and mucous membranes. <i>Candida</i> spp. are capable of breaching the epithelial barrier of immunocompromised patients with neutrophil and cell-mediated immune dysfunctions and can also disseminate to multiple organs through the bloodstream. Here we examined the action of innate defense regulator 1018 (IDR-1018), a 12-amino-acid-residue peptide derived from bovine bactenecin (Bac2A): IDR-1018 showed weak antifungal and antibiofilm activity against a <i>Candida albicans</i> laboratory strain (ATCC 10231) and a clinical isolate (CI) (MICs of 32 and 64 μg · ml<sup>-1</sup>, respectively), while 8-fold lower concentrations led to dissolution of the fungal cells from preformed biofilms. IDR-1018 at 128 μg · ml<sup>-1</sup> was not hemolytic when tested against murine red blood cells and also has not shown a cytotoxic effect on murine monocyte RAW 264.7 and primary murine macrophage cells at the tested concentrations. IDR-1018 modulated the cytokine profile during challenge of murine bone marrow-derived macrophages with heat-killed <i>C. albicans</i> (HKCA) antigens by increasing monocyte chemoattractant protein 1 (MCP-1) and interleukin-10 (IL-10) levels, while suppressing tumor necrosis factor alpha (TNF-α), IL-1β, IL-6, and IL-12 levels. Mice treated with IDR-1018 at 10 mg · kg<sup>-1</sup> of body weight had an increased survival rate in the candidemia model compared with phosphate-buffered saline (PBS)-treated mice, together with a diminished kidney fungal burden. Thus, IDR-1018 was able to protect against murine experimental candidemia and has the potential as an adjunctive therapy.
Inverse design in nanoscale heat transport via interpolating interfacial phonon transmission (2022)

Abstract We introduce a methodology for density-based topology optimization of non-Fourier thermal transport in nanostructures, based upon adjoint-based sensitivity analysis of the phonon Boltzmann transport equation (BTE) and a novel material interpolation technique, the “transmission interpolation model” (TIM). The key challenge in BTE optimization is handling the interplay between real- and momentum-resolved material properties. By parameterizing the material density with an interfacial transmission coefficient, TIM is able to recover the hard-wall and no-interface limits, while guaranteeing a smooth transition between void and solid regions. We first use our approach to tailor the effective thermal conductivity tensor of a periodic nanomaterial; then, we maximize classical phonon size effects under constrained diffusive transport, identifying a promising new thermoelectric material design. Our method enables the systematic optimization of materials for heat management and conversion and, more broadly, the design of devices where diffusive transport is not valid.
Identification of a Second Major Tumor-Specific Antigen Recognized by CTLs on Mouse Mastocytoma P815 (1999)

Murine mastocytoma P815 induces CTL responses against at least four distinct Ags (AB, C, D, and E). Recent studies have shown that the main component of the CTL response against the P815 tumor is targeted against Ags P815AB and P815E. The gene P1A has been well characterized. It encodes the P815AB Ag in the form of a nonameric peptide containing two epitopes, P815A and P815B, which are recognized by different CTLs. Here, we report the identification of the P815E Ag. Using a cDNA library derived from tumor P815, we identified the gene coding for P815E. We also characterized the antigenic peptide that anti-P815E CTLs recognize on the MHC class I molecule H-2Kd. The P815E Ag results from a mutation within an ubiquitously expressed gene encoding methionine sulfoxide reductase, an enzyme that is believed to be important in the protection of proteins against the by-products of aerobic metabolism. Surprisingly, immunizing mice i.p. with syngeneic tumor cells (L1210) that were constructed to express B7-1 and P815E did not induce resistance against live P815, even though a strong anti-P815E CTL response was observed with splenocytes from immunized animals.
Rapid composition screening for perovskite photovoltaics via concurrently pumped ultrasonic spray coating (2016)

Concurrently pumped ultrasonic spray coating is implemented for rapid composition screening and in situ bandgap control of perovskite photovoltaics, achieving 15.7% efficiency for devices and 11.7% for modules, and tested under continuous maximum power point tracking.
A Compact Reconfigurable Resonator-Based Direct Current Sensing System (2022)

A compact and reconfigurable current readout system is presented that is based on microelectromechanical system (MEMS) resonators. The proposed system generates analog and digital outputs by electrothermally tuning the microbeam resonant frequency according to variations in the input current signal. A single resonator is utilized to generate the analog output, while a resonator array operating at different frequencies is utilized to generate a digital one-hot output. Experiments showed that the frequency shift is linearly proportional to the square of the current. The single resonator has a detection limit of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.16 ~\mu \text{A}$ </tex-math></inline-formula> , and the resonator array offers good static linearity with a maximum differential/integral non-linearity of 0.55/0.23 least significant bits. The single resonator is suitable for applications requiring high-resolution measurements. The proposed resonator sensing system has a small footprint, is compatible with large-scale integration, and provides considerable flexibility for reconfiguration.
Faculty Opinions recommendation of A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. (2009)

We performed a genome-wide siRNA screen in mouse embryonic stem (ES) cells to identify genes essential for selfrenewal, and found 148 genes whose down-regulation caused differentiation. Many of the identified genes function in gene regulation and/or development, and are highly expressed in ES cells and embryonic tissues. We further identified target genes of two transcription regulators Cnot3 and Trim28. We discovered that Cnot3 and Trim28 co-occupy many putative gene promoters with c-Myc and Zfx, but not other pluripotency-associated transcription factors. They form a unique module in the self-renewal transcription network, separate from the core module formed by Nanog, Oct4, and Sox2. The transcriptional targets of this module are enriched for genes involved in cell cycle, cell death, and cancer. This supports the idea that regulatory networks controlling self-renewal in stem cells may also be active in certain cancers and may represent novel anti-cancer targets. Our screen has implicated over 100 new genes in ES cell self-renewal, and illustrates the power of RNAi and forward genetics for the systematic study of self-renewal.
ChemInform Abstract: Orthorhombic NaxMnO2 as a Cathode Material for Secondary Sodium and Lithium Polymer Batteries. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Correlation of HOXD3 promoter hypermethylation with clinical and pathologic features in screening prostate biopsies (2014)

H3PH is associated with clinicopathologic features. The data indicate that H3PH is more common in older higher risk patients. More research is needed to determine the role of this marker in optimizing management strategies in men with newly diagnosed prostate cancer.
Supplementary Table 4 from MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors (2023)

&lt;p&gt;PDF - 69K, Supplemental Table S4. List of the mechanistic model parameters and reactions.&lt;/p&gt;
Eliminating the transverse instabilities of Kerr solitons (2002)

Summary form only given. Despite the progress in the field of optical spatial solitons, transverse instability (TI) has remained a problem. For a spatial optical (1+1)D soliton that is self-trapped in one dimension, x, is uniform in the transverse dimension, y, and is propagating along z, TI causes the soliton to break up along y into an array of 2D filaments. Here we show that if the soliton is made sufficiently incoherent in its transverse uniform dimension, y. then TI is completely eliminated.