gebhart/patrepeval huggingface dataset:
Role of magnetic Fe3O4 graphene oxide in chemiluminescent aptasensors capable of sensing tumor markers in human serum (2013)

Using π–π stacking interaction between magnetic Fe3O4 graphene oxide nanoparticles and impurities (e.g., biomolecules, free prostate specific antigen (PSA) aptamer-conjugated TEX615 that does not bind with PSA) in human serum, a rapid aptasensor with 1,1′-oxalyldiimidazole chemiluminescence (ODI-CL) detection was developed for the quantification of PSA, a tumor marker. The complexes, PSA bound with PSA aptamer-conjugated TEX615, were formed in human serum while the mixture (1 : 1 volume ratio) of PSA in 25% human serum diluted in Tris–HCl buffer (pH 7.5) and PSA aptamer-conjugated TEX615 in Tris–HCl buffer was incubated for 30 minutes. After the incubation, the impurities capable of reducing the efficiency of the aptasensor were removed using magnetic Fe3O4 graphene oxide nanoparticles. With the addition of ODI CL reagents (e.g., ODI, H2O2), finally, PSA in each sample was quantified within 1 second. The sensitivity of the aptasensor with good accuracy, precision, and recovery was as good as those of enzyme immunoassays with absorbance and chemiluminescence detections operated using time-consuming procedures such as multiple-time incubation and washing and expensive and intractable antibodies.
Importance of Implantation Sequence in the Formation of Nanometer Size Colloid Particles Embedded in Amorphous SiO2: Formation of Composite Colloids with Cu Core and aCu2O Shell by Coimplantation of Cu and F (1995)

A striking difference in the properties of nanosized colloid particles between amorphous Si${\mathrm{O}}_{2}$ substrates implanted with Cu and F ions in a differing sequence is reported. No significant change in an optical band peaking at 2.2 eV due to plasma oscillation of Cu nanosize colloids is observed by implanting F and then Cu. The 2.2 eV band is not perceived with implantation of F ions into Cu-implanted substrates. Although colloid particles identified are Cu in the former sequence, those formed in the latter have a dual structure composed of Cu (core) and ${\mathrm{Cu}}_{2}$O (shell). This is explained by oxidation of the outer part of Cu colloids by energetic O recoiled from the silica structure by implanted F.
Five New Bioactive Sesquiterpenes from the Fungus Radulomyces confluens (Fr.) Christ (1998)

The three protoilludanes radulone A (1), radulone B (2) and radudiol (3), the illudalane radulactone (4) and the illudane radulol (5) were isolated from the extracts of the culture fluids of the basidiomycete Radulomyces confluens. The structures of the five new compounds were determined by spectroscopic techniques. Radulone A (1) is a potent inhibitor of human and bovine platelet aggregation stimulated by different agonists, inhibiting preferentially the aggregation of human platelets induced by ADP with an IC50 value of 2 microM. In addition 1 exhibits cytotoxic and antimicrobial activities. The other four compounds exhibited weak antimicrobial and cytotoxic activity.
Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor‐specific antibodies (2019)

In the field of transplantation, the humoural immune response against mismatched HLA antigens of the donor is associated with inferior graft survival, but not in every patient. Donor-specific HLA antibodies (DSA) of different immunoglobulin G (IgG) subclasses may have differential effects on the transplanted organ. Recombinant technology allows for the generation of IgG subclasses of a human monoclonal antibody (mAb), while retaining its epitope specificity. In order to enable studies on the biological function of IgG subclass HLA antibodies, we used recombinant technology to generate recombinant human HLA mAbs from established heterohybridomas. We generated all four IgG subclasses of a human HLA class I and class II mAb and showed that the different subclasses had a comparable affinity, normal human Fc glycosylation, and retained HLA epitope specificity. For both mAbs, the IgG1 and IgG3 isotypes were capable of binding complement component 3d (C3d) and efficient in complement-dependent cell lysis against their specific targets, while the IgG2 and IgG4 subclasses were not able to induce cytotoxicity. Considering the fact that the antibody-binding site and properties remained unaffected, these IgG subclass HLA mAbs are excellent tools to study the function of individual IgG subclass HLA class I and class II-specific antibodies in a controlled fashion.
Design and Experimental Verification of a 50 kW Interior Permanent Magnet Synchronous Machine (2006)

This paper presents the design details for an IPM machine designed to deliver 50 kW constant power over a 5:1 speed range extending from 850 rpm to 4250 rpm, with a gradual reduction in the required output power up to 8000 rpm (25 kW). Electromagnetic, thermal, and structural considerations have been included in the design optimization process. The resulting machine is designed with two magnet layers per pole and a distributed stator winding. Special features of the machine include its deep stator slots and four-layer winding, made necessary by the desire to minimize the machine's moment of inertia. Test results available to date demonstrate that the machine is capable of delivering the required output torque and power, and the agreement between the predicted and measured machine parameters is generally quite good. Calculated iron losses for high-speed flux-weakening operation are presented in the final section of the paper, illustrating the challenges associated with minimizing the impact of high-frequency harmonic flux density components
NASA Goddard Space Flight Center Cooperative Enterprise (2004)

The viability of a Capillary Heat Pump (CHP) concept using a Loop Heat Pipe evaporator and an eductor in a closed loop to reject heat at a higher temperature than it is acquired at with the goal of reducing spacecraft radiator area is examined. Eductor inefficiency resulting from the mixing of high velocity motive flow with low velocity suction flow may preclude spacecraft radiator area savings. The utility of a CHP for thermal management may be limited to those missions where system mass is of secondary concern compared to system reliability, or where a heat pump is required to accommodate relatively high thermal rejection temperatures. Shearography techniques for nondestructive inspection and evaluation were examined for two unique applications. Shearography is shown to give good results in evaluating the quality of bonds holding lead tiles to the SWIFT spacecraft BAT gamma ray mask. Also, a novel technique was developed allowing specular objects to be inspected using shearography to evaluate bonding between the skin and core of a specular surface honeycomb structure. Large-scale bond failures are readily identified.
Resveratrol Inhibits Nitric Oxide and Prostaglandin E 2 Production by Lipopolysaccharide-Activated C6 Microglia (2007)

Resveratrol, a natural polyphenolic antioxidant found in red wine and grapes, has been reported to exert a variety of important pharmacological effects, including anti-inflammatory, cardioprotective, and cancer chemopreventive properties. In the present study, we investigated the effect of resveratrol on the production of nitric oxide (NO) and prostaglandin (PG) E2 by lipopolysaccharide (LPS)-activated C6 microglia. Exposure of cultured rat C6 astroglioma cells to LPS increased their release of NO and PGE2 and their inducible expression of NO synthase and cyclooxygenase-2, all of which were significantly inhibited by resveratrol pretreatment. Further studies revealed that resveratrol suppressed LPS-induced nuclear translocation and activation of nuclear factor κB (NF-κB). These results demonstrate a potent suppressive effect of resveratrol on pro-inflammatory responses of microglia by modulation of NF-κB activity, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation.
Study of Nutritional Defects of a Nonfat Milk Solids and Glucose Diet for Young Calves (1966)

Very young calves fed a diet consisting of nonfat milk solids and glucose developed a characteristic syndrome including signs similar to those reported with deficiencies of thiamine, biotin, and magnesium. Supplementation with a B-vitamin mixture including high levels of thiamine and biotin or with magnesium did not prevent the problem, but a combination of these two regimes appeared to impart considerable protection. It was suggested that the dietary defect was a complicated one and may involve a general electrolyte imbalance.
DIPG-59. UPREGULATION OF PRENATAL PONTINE ID1 SIGNALING IN DIPG (2020)

Abstract BACKGROUND Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors with no curative therapies. Inhibitor of DNA binding (ID) proteins are key regulators of gene differentiation during embryogenesis. Previous work has shown that H3F3A and ACVR1 mutations increase ID1 expression in cultured astrocytes, but this has not been validated in human DIPG, nor has the regulation and targetability of ID1 been explored in DIPG. RESULTS Analysis of post-mortem tissue and multiple human datasets showed ID1 to be elevated in DIPG, and to correlate with reduced survival. In a multi-focal autopsy of a DIPG case, we also found ID1 expression to be heterogeneous and to correlate with tumor invasion. Chromatin immunoprecipitation qPCR (ChIP-qPCR) revealed elevated H3K27ac and low H3K27me3 at ID1 regulatory regions (enhancers/promoters) in DIPG tissue compared to normal brain, regardless of H3 or ACVR1 mutation status. Analysis of publicly-available ISH and ChIP-sequencing data of developing murine brains revealed H3K27ac at ID1 enhancers to be elevated in the prenatal hindbrain compared to prenatal forebrain and midbrain, and all postnatal brain regions. ID1 shRNA-mediated knockdown of primary human H3K27M DIPG cells (DIPG007) significantly reduced invasion and migration. We also treated DIPG007 cells with cannabidiol (CBD) and found reduced viability at clinically relevant dosing (IC50=2.4 uM) with dose-dependent reduction in ID1 protein. CONCLUSIONS These findings indicate that a multifactorial (genetic and regionally-based) epigenetic upregulation of ID1 drives DIPG invasiveness and is targetable with CBD. ID1 knockdown and CBD treatment experiments in murine models of DIPG are ongoing.
High-responsivity 100GHz waveguide UTC photodetector (2017)

We present a double cladding, high-mesa-type waveguide UTC photodetector with an improved the responsivity. In this device structure, an InGaAs thin core layer was sandwiched by p-InP/InGaAsP and n-InP/InGaAsP cladding layers, including a UTC structure, in order to obtain a good optical coupling between the waveguide and the fiber. By comparing the resulting mode field with that obtained with a single cladding layer structure, we confirmed that the vertical mode field was enlarged. Without a spot size converter, the measured responsivity was as high as 0.6 A/W at 1550 nm, which suggests a responsivity three times higher than that of back-illuminated structures, and higher responsivity than that of previous reports. A high frequency performance (f<sub>3dB</sub> = 100 GHz) was also measured. The device structure, including the layer, doping level conditions, and optical fiber coupling results are discussed, and its performance is characterized in detail.
A. J. Ayer. Names and descriptions. Logique et analyse, n.s. vol. 5 no. 20 (for 1962, pub. 1963), pp. 199–202. - L. J. Russell, J. Dopp, Findlay, A. J. Ayer. Discussion. Logique et analyse, n.s. vol. 5 no. 20 (for 1962, pub. 1963), pp. 202–211. (1964)

A. J. Ayer. Names and descriptions. Logique et analyse, n.s. vol. 5 no. 20 (for 1962, pub. 1963), pp. 199–202. - L. J. Russell, J. Dopp, Findlay, A. J. Ayer. Discussion. Logique et analyse, n.s. vol. 5 no. 20 (for 1962, pub. 1963), pp. 202–211. - Volume 29 Issue 4
Prague Dependency Treebank -- Consolidated 1.0 (2020)

We present a richly annotated and genre-diversified language resource, the Prague Dependency Treebank-Consolidated 1.0 (PDT-C 1.0), the purpose of which is - as it always been the case for the family of the Prague Dependency Treebanks - to serve both as a training data for various types of NLP tasks as well as for linguistically-oriented research. PDT-C 1.0 contains four different datasets of Czech, uniformly annotated using the standard PDT scheme (albeit not everything is annotated manually, as we describe in detail here). The texts come from different sources: daily newspaper articles, Czech translation of the Wall Street Journal, transcribed dialogs and a small amount of user-generated, short, often non-standard language segments typed into a web translator. Altogether, the treebank contains around 180,000 sentences with their morphological, surface and deep syntactic annotation. The diversity of the texts and annotations should serve well the NLP applications as well as it is an invaluable resource for linguistic research, including comparative studies regarding texts of different genres. The corpus is publicly and freely available.
Realization of single-moded broadband air-guiding photonic bandgap fibers (2006)

In this letter, we propose a novel type of air-guiding photonic bandgap fiber, which exhibits an effectively single-mode operation with a low confinement loss over a wide wavelength range, extended from 1460 to 1840 nm. For several realistic structural parameters, the wavelength dependence of the dispersion as well as the confinement loss properties are investigated through a full-vector modal solver based on the finite-element method. In particular, we optimize the structure so as to exhibit the following performance: effectively single-mode operation from 1460 to 1840 nm, with corresponding confinement loss of the fundamental air-guided mode of 8.8times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> dB/km, and enhancement of the confinement loss of the higher order mode of 43 dB/m for ten-ring structure
An Adaptive Architecture for Hierarchical Vision Systems (2000)

We describe a machine learning architecture for hierarchical vision systems. These vision systems work by successively grouping visual constructs at one level, selecting the most promising, and passing them up to higher levels of processing. This continues from the pixel-level of the image to the object-model level. Traditionally, researchers have used static heuristics at each level to select the best constructs. In practice, this approach is brittle, because people have not been successful at surveying the evidence necessary for robust performance, and is static, because designers have not incorporated learning mechanisms that would let the system improve its performance with the aid of user feedback. The machine learning architecture proposed herein is an attempt to address both of these issues. Introduction We have devised a novel machine learning architecture that shows promise of significantly improving the accuracy of hierarchical machine vision systems. The prop...
SMART SCREWDRIVER FOR ACCURATE and INTUITIVE SURGERY USING THE EXACTECH GPS system (2018)

Major aspects on long-term outcome in Total Knee Arthroplasty are the correct alignment of the implant with the mechanical load axis, the rotational alignment of the components as well as good soft tissue balancing. To reduce the variability of implant alignment and at the same time minimise the invasiveness different computer assisted systems have been introduced.To achieve accuracy as high as those of a robotic system but with a pure mechanically adjustable cutting block, the Exactech GPS system has been developed. The new concept comprises a seamlessly planning and navigation screen with an integrated optical tracking system for fast and accurate acquisition and verification of anatomical landmarks within the sterile field as well as a tiny cutting guide for accurate transfer of the planned bone resections.Using a conventional screwdriver the cutting block could be accurately aligned with the planned resection by controlling the current position of the cutting block on the navigation screen. To save ti...
Elbow Region (2020)

This chapter discusses conditions affecting the elbow region (i.e. any of the structures affecting the elbow joint and surrounding area). A brief discussion of the clinically relevant local anatomy is followed by a detailed description of the history, physical examination, and diagnostic findings typically found in patients presenting with pathology of this region.
Efficient concurrency control in multidimensional access methods (1999)

The importance of multidimensional index structures to numerous emerging database applications is well established. However, before these index structures can be supported as access methods (AMs) in a “commercial-strength” database management system (DBMS), efficient techniques to provide transactional access to data via the index structure must be developed. Concurrent accesses to data via index structures introduce the problem of protecting ranges specified in the retrieval from phantom insertions and deletions (the phantom problem). This paper presents a dynamic granular locking approach to phantom protection in Generalized Search Trees(GiSTs), an index structure supporting an extensible set of queries and data types. The granular locking technique offers a high degree of concurrency and has a low lock overhead. Our experiments show that the granular locking technique (1) scales well under various system loads and (2) similar to the B-tree case, provides a significantly more efficient implementation compared to predicate locking for multidimensional AMs as well. Since a wide variety of multidimensional index structures can be implemented using GiST, the developed algorithms provide a general solution to concurrency control in multidimensional AMs. To the best of our knowledge, this paper provides the first such solution based on granular locking.
Zeolites as Pheromone Dispensers (2001)

Modification of the chemical and structural properties of zeolites has led to the preparation of an optimized zeolitic dispenser for insect attractants such as n-decanol and trimedlure. The impact of zeolite variables such as the framework Si/Al ratio, nature of compensating cation, nature and strength of acid groups, and pore dimensions on the kinetics of emission has been studied, and the results are as follows. Zeolite pore dimensions and the presence or absence of acid sites have the greatest effect on the rate of release, decreasing with decreasing pore diameter and increasing acidity. Further tuning of the release characteristics is achieved by controlling the polarity and the polarizability of the framework by increasing the Si/Al ratio and nature of the compensating cations, i.e., the higher the polarizability and the lower the polarity, the slower the release of attractants.
Response and Rebuttal to Editorial Comment on “Distinguishing Failure to Cure From Complication After Penile Prosthesis Implantation” (2017)

The commentator's perspective is valued for helping to move this discussion forward. Because a prosthetic surgeon's main goal is to treat erectile dysfunction, we believe that a “cure” is the restoration of a functionally erect penis to engage in adequate sexual intercourse. Certain postoperative problems (eg, pump malfunction) disallow this cure. According to the Calvien-Dindo classification of surgical complications, under what grade would these problems fall? If they do not mandate surgical repair, would they fall under category III (requiring surgical, endoscopic, or radiologic intervention)? In contrast, a postoperative problem such as erosion mandates surgical reintervention and typically constitutes a complication. Certainly, the determination of failure to cure in penile prosthesis implantation surgery would seemingly change at various postsurgical time points. A practical suggestion is to consider a time point after standard recovery when there is fair expectation of use of the device, such as 3 to 6 months. Part of our goal was to bring a widely accepted criterion for classification of surgical complications into the realm of penile prosthesis implantation surgery. Dindo and Clavien1 stated that “if the original purpose of surgery has not been achieved, this is not a complication but a ‘failure to cure’” (eg, inadequate erection after surgery for erectile dysfunction). They defined a surgical complication as “any deviation from the ideal postoperative course that is not inherent in the procedure and does not comprise a failure to cure.” Thus, failure to cure describes a postoperative problem that is categorically distinct from a complication.
107Gb/s DPSK-3ASK Optical Transmission over SSMF (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. T. Teipen and M. H. Eiselt, "107Gb/s DPSK-3ASK Optical Transmission over SSMF," in National Fiber Optic Engineers Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper NMB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Chapter 1: Spreading political knowledge: English newspapers, correspondents, travellers (2017)

English purity campaigners saw their own country as a net exporter of the ideas, laws and movements that drove sexuality politics around the world. Parallels and coincidences in global sexuality politics, past and present, have sometimes been attributed to the diffusion of ideas and identities. This chapter examines the processes by which purity movements may have spread from England to other parts of the British Empire. English purity campaigners recognised distinctions within both Indian and English society, which further complicated the hierarchical geographies of sexuality politics. Invoking the imperial power of which she was often critical, Ellice Hopkins, argued that English purity movements would inevitably 'influence in the world at large. Perhaps the most tangible way in which purity campaigns were extended was through travel. Before he ventured into travel and travel-writing proper, Alfred Stace Dyer used quasi-travel narratives to strengthen the overseas work of English purity campaigns.
Pre-deployment Verification and Predicted Mapping Speed of MUSCAT (2020)

The Mexico-UK Submillimetre Camera for AsTronomy (MUSCAT) is a 1.1 mm receiver consisting of 1,500 lumped-element kinetic inductance detectors (LEKIDs) for the Large Millimeter Telescope (LMT; Volcán Sierra Negra in Puebla, México). MUSCAT utilises the maximum field of view of the LMT's upgraded 50-metre primary mirror and is the first México-UK collaboration to deploy a millimetre/sub-mm receiver on the Large Millimeter Telescope. Using a simplistic simulator, we estimate a predicted mapping speed for MUSCAT by combining the measured performance of MUSCAT with the observed sky conditions at the LMT. We compare this to a previously calculated bolometric-model mapping speed and find that our mapping speed is in good agreement when this is scaled by a previously reported empirical factor. Through this simulation we show that signal contamination due to sky fluctuations can be effectively removed through the use of principle component analysis. We also give an overview of the instrument design and explain how this design allows for MUSCAT to be upgraded and act as an on-sky demonstration testbed for novel technologies after the facility-class TolTEC receiver comes online.