gebhart/patrepeval huggingface dataset:
Maine EPSCoR End-to-End Connectivity for Sustainability Science Collaboration (2013)

Project DescriptionThis RII C2 proposal from Maine (ME) EPSCoR is focused on addressing last-mile bottlenecks at seven campuses of the University of Maine System. Maine's Research and Education Network, MaineREN, delivers high performance inter-campus fiber connectivity to public and private institutions across the state, but the intra-campus networking has lacked the same investment by the state.The proposed improvements include:- Rewiring eight buildings at the University of Maine Orono Campus (UMaine) with Cat-6 cable, increasing end-to-end performance to 10 Gbps.- Upgrading the fiber backbone between the two University of Southern Maine (USM) campuses, one in Portland and one in Gorham, 12 miles apart. In addition, upgrades will be done for the buildings housing the ME RII Track-1 researchers, including the Law Building, Library, Bailey Hall, and the buildings that make up the fiber core for the Portland campus. - Upgrades to edge routers to connect to the MaineREN backbone for UMaine Augusta (UMA), UMaine Farmington (UMF), UMaine Fort Kent (UMFK), UMaine Machias (UMM), and UMaine Presque Isle (UMPI). Intellectual MeritThe proposed upgrades in network connections will greatly improve the networking capacity available to the University of Maine system and enable researchers to take advantage of state-wide upgrades with improved end-to-end performance. The proposed RII C2 connectivity improvements will support the Maine RII Track-1 Sustainability Science Initiative (SSI) by increasing bandwidth availability for the SSI data management and visualization approaches. SSI is advancing the emerging field of sustainability science in three integrative ways: 1) examining interactions between social and ecological systems (SES) as landscapes change in response to urbanization, forest management, and climate variability; 2) investigating how much SES knowledge affects, and is influenced by, the actions and decision of stakeholders, with a goal of strengthening connections between knowledge and actions; 3) evaluating the factors that facilitate and impede interdisciplinary collaboration, with a goal of identifying and implementing individual and institutional best practices that are needed to support successful interdisciplinary research programs in sustainability science.Broader ImpactsBy filling in relatively small gaps in the infrastructure, Maine will be able to make very large gains in the effectiveness of the state's cyberinfrastructure (CI) that will allow researchers to fully utilize investments to improve research effectiveness, promote collaboration, improve K-12 interaction, and develop the future workforce of the state. The networking upgrades will support the 300 researchers, students, and stakeholders that are part of the SSI collaboration over 17 different disciplinary fields. The SSI activities have the potential to increase Maine's research capacity and competitiveness and grow Maine's green innovation economy. The proposed project will leverage the RII Track-1 programs for broader impacts.
Hydration of Wheat Flour Water-Unextractable Cell Wall Material Enables Structural Analysis of Its Arabinoxylan by High-Resolution Solid-State 13C MAS NMR Spectroscopy (2022)

To enable its structural characterization by nuclear magnetic resonance (NMR) spectroscopy, the native structure of cereal water-unextractable arabinoxylan (WU-AX) is typically disrupted by alkali or enzymatic treatments. Here, WU-AX in the wheat flour unextractable cell wall material (UCWM) containing 40.9% ± 1.5 arabinoxylan with an arabinose-to-xylose ratio of 0.62 ± 0.04 was characterized by high-resolution solid-state NMR without disrupting its native structure. Hydration of the UCWM (1.7 mg H<sub>2</sub>O/mg UCWM) in combination with specific optimizations in the NMR methodology enabled analysis by solid-state <sup>13</sup>C NMR with magic angle spinning and <sup>1</sup>H high-power decoupling (<sup>13</sup>C HPDEC MAS NMR) which provided sufficiently high resolution to allow for carbon atom assignments. Spectral resonances of <i>C</i>-1 from arabinose and xylose residues of WU-AX were here assigned to the solid state. The proportions of un-, mono-, and di-substituted xyloses were 59.2, 19.5, and 21.2%, respectively. <sup>13</sup>C HPDEC MAS NMR showed the presence of solid-state fractions with different mobilities in the UCWM. This study presents the first solid-state NMR spectrum of wheat WU-AX with sufficient resolution to enable assignment without prior WU-AX solubilization.
Automatic generation of trajectory planners for industrial robots (1986)

The control of industrial robots is usually divided into several sequential stages. Trajectory planning is an important off-line stage which is concerned with the generation of a time history of a robot's joint position, velocity, acceleration, and input torques. A number of trajectory planning methods have been developed [1], [4]-[6], [10], [11], [13], which usually entail complex computations and algebraic manipulations. Programming this sort of trajectory planners is very complex and error-prone, thereby limiting their applicability. To remove this limitation, we have begun the development of software for automating the trajectory planning, called the Automatic Trajectory Planner Generator (ATPG). This paper describes important components of the ATPG: three trajectory planners, data structures for describing geometric paths, generation of the robot's dynamic equations and constraint functions, and ancillary software. A large portion of the ATPG has been completed, and the remaining portion is currently under development.
Perioperative Fluid Management and Clinical Outcomes in Adults (2005)

The administration of IV fluid to avoid dehydration, maintain an effective circulating volume, and prevent inadequate tissue perfusion should be considered, along with the maintenance of sleep, pain relief, and muscular relaxation, a core element of the perioperative practice of anesthesia. Knowledge of the effects of different fluids has increased in recent years, and the choice of fluid type in a variety of clinical situations can now be rationally guided by an understanding of the physicochemical and biological properties of the various crystalloid and colloid solutions available. However, there are few useful clinical outcome data to guide this decision. Deciding how much fluid to give has historically been more controversial than choosing which fluid to use. A number of clinical studies support the notion that an approach based on administering fluids to achieve maximal left ventricular stroke volume (while avoiding excess fluid administration and consequent impairment of left ventricular performance) may improve outcomes. In this article, we review the available fluid types and strategies of fluid administration and discuss their relationship to clinical outcomes in adults.
Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules perfused in vitro. (1989)

1. The effect of the microtubule-disruptive agent, nocodazole (methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl] carbamate), on the water permeability response to vasopressin or the synthetic cyclic AMP analogue, 8-parachlorophenylthio-cyclic AMP (8-CPT-cAMP), has been investigated in isolated cortical collecting tubules from rabbit kidneys, perfused in vitro. 2. Pre-treatment with nocodazole, 1-4 micrograms ml-1, had no significant effect on basal water permeability, but inhibited the increase in hydraulic conductivity elicited by vasopressin, 50 microU ml-1, in a dose-dependent manner. Inhibition of the response to the hormone averaged 65 +/- 6% (n = 8, P less than 0.001) at a nocodazole concentration of 4 micrograms ml-1. 3. Nocodazole, 1-4 micrograms ml-1, had no effect on the increase in lumen-negative potential difference (PD) induced by the hormone. 4. Pre-treatment with nocodazole, 4 micrograms ml-1, inhibited the development of the water permeability response to 8-CPT-cAMP, 1.8 x 10(-5) M, by 45 +/- 7% (n = 7, P less than 0.001). 5. When collecting tubules were exposed to nocodazole, 4 micrograms ml-1, after the hydrosmotic response to vasopressin had been fully established, the drug had no inhibitory effect on the maintenance of a high water permeability. 6. The results are consistent with the view that cytoplasmic microtubules play a role in the initiation of the water permeability response to vasopressin in the mammalian cortical collecting tubule at a cellular site beyond the generation of cyclic AMP.
Herstellung von Oligosaccharid‐Bibliotheken durch Zufalls‐Glycosylierung (1995)

Je sechs auf einen Streich. Durch eine neue Strategie zur Zufalls‐Glycosylierung von nichtgeschützten Zuckern gelang die Herstellung von kleinen Oligosaccharid‐Bibliotheken. Mit Tri‐ O ‐benzyl‐ L ‐fucopyranosyltrichloracetimidat als Donor und βGal(1→ n )βGlcNacOR ( n  3, 4, 6; R  (CH 2 ) 8 OC 6 H 4 ‐ p ‐OMe) als Acceptoren entstehen in DMF jeweils alle sechs Trisaccharide in etwa gleichen Mengen. Erstaunlich ist, daß dabei alle freien OH‐Gruppen ähnlich schnell fucosyliert werden. magnified image
A General Procedure for M itsunobu Inversion of Sterically Hindered Alcohols: Inversion of Menthol. (1S,2S,5R)‐5‐Methyl‐2‐(1‐Methylethyl)Cyclohexyl 4‐Nitrobenzoate (2003)

Abstract A General procedure for Mitsunobu inversion of sterically hindered alcohols: inversion of menthol. (1S,2S,5R)‐5‐methyl‐2‐(1‐methylethyl)cyclohexyl 4‐nitrobenzoate product: (1S,2S,5R)‐5‐Methyl‐2‐(1‐methylethyl)cyclohexyl 4‐nitrobenzoate
Induction of PSMA and Internalization of an Anti-PSMA mAb in the Vascular Compartment (2016)

Cancer cells are able to induce PSMA expression in HUVECs, in vitro and in vivo, allowing internalization of PSMA-specific mAbs and nanoparticles bearing a PSMA-binding ligand/inhibitor. Mol Cancer Res; 14(11); 1045-53. ©2016 AACR.
CanariCam-Polarimetry: A Dual-Beam 10 m Polarimeter for the GTC (2005)

Original paper can be found at: http://161.58.115.79/pubs/cs/328.html--Copyright Astronomical Society of the Pacific
Microfabricated Structures for Evaluation of Tactile Sensitivity (2010)

A novel, sensitive, inexpensive test platform for rapid assessment of touch sensation is presented. The device translates basic research performed on the physiological properties of skin touch receptors into a clinical test for early diagnosis of diabetic and other types of neuropathy. The platform consists of a series of coin-shaped structures (550μm diameter, 1.5 to 30μm high) that a test subject attempts to feel by touch using a fingertip. The structures are made using a simple SU-8 process, standard lithography and dry etching. Early results show that there is some variability in sensitivity based on age, but "normal" subjects of most ages can readily detect bumps of heights below 5 microns, whereas subjects with neuropathy cannot. We believe that this new marker for tactile deficiency can rapidly be brought into clinical use. This paper demonstrates a successful collaborative project between a university microfabrication facility and a physician-led clinical study.
Coding artifacts reduction using edge map guided adaptive and fuzzy filtering (2005)

The work presents a new adaptive approach for blocking and ringing artifact reduction. In order to avoid smearing of the image details, the proposed method first performs visual artifact detection and then applies adaptive filtering to the corrupted blocks. Both visual artifact detection and filtering are guided by an edge map which is constructed based on local features. A fuzzy identity filter is used for image de-ringing. Since it possesses a good edge preserving property and the filtering operation is applied to the edge blocks only (smooth and textured blocks are unaltered), the proposed method shows great effectiveness of both artifact reduction and detail preservation. Experiments demonstrate better results compared with other methods.
Nonlinear Seismic Responses of Container Cranes Including the Contact Problem Between Wheels and Rails (2004)

This paper presents a modeling method based on multibody dynamics formulation for simulating the three-dimensional nonlinear seismic response of a large, movable container crane, including the contact problem regarding the wheels attached to the bottom of its legs and the rails on which they ride. As a container crane is large and flexible structure, its wheels should be lifted up and derailed due to the seismic excitation. The contact configuration and the contact forces between the wheels and the rail or the ground that significantly affect the seismic response of the structure are classified and calculated in reference to geometric relationships between contact-judging markers on the wheels and the rails. It is found that the numerical simulations with the presented modeling method quite accurately simulates the nonlinear seismic response of a container crane including the uplifting and derailment behavior of the wheels that is found in large-scale model shaking tests.
Improved Superconducting Qubit Readout by Qubit-Induced Nonlinearities (2010)

In dispersive readout schemes, qubit-induced nonlinearity typically limits the measurement fidelity by reducing the signal-to-noise ratio (SNR) when the measurement power is increased. Contrary to seeing the nonlinearity as a problem, here we propose to use it to our advantage in a regime where it can increase the SNR. We show analytically that such a regime exists if the qubit has a many-level structure. We also show how this physics can account for the high-fidelity avalanchelike measurement recently reported by Reed et al. [arXiv:1004.4323v1].
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 (2020)

Abstract Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19. Computational methods to predict serodiagnostic epitopes that are specific for the pathogen could help accelerate the development of new diagnostics. A systematic survey of 27 SARS-CoV-2 proteins was conducted to assess whether existing B-cell epitope prediction methods, combined with comprehensive mining of sequence databases and structural data, could predict whether a particular protein would be suitable for serodiagnosis. Nine of the predictions were validated with recombinant SARS-CoV-2 proteins in the ELISA format using plasma and sera from patients with SARS-CoV-2 infection, and a further 11 predictions were compared to the recent literature. Results appeared to be in agreement with 12 of the predictions, in disagreement with 3, while a further 5 were deemed inconclusive. We showed that two of our top five candidates, the N-terminal fragment of the nucleoprotein and the receptor-binding domain of the spike protein, have the highest sensitivity and specificity and signal-to-noise ratio for detecting COVID-19 sera/plasma by ELISA. Mixing the two antigens together for coating ELISA plates led to a sensitivity of 94% (N=80 samples from persons with RT-PCR confirmed SARS-CoV2 infection), and a specificity of 97.2% (N=106 control samples).
Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients (2000)

High serum concentrations of vascular endothelial growth factor (S-VEGF) and basic fibroblast growth factor (S-bFGF) are associated with unfavorable clinical characteristics in cancer. The combined effect of S-VEGF and S-bFGF on the survival of 200 patients with non-Hodgkin lymphoma (NHL) was studied. High S-VEGF and S-bFGF at diagnosis were associated with poor survival with the medians, the highest tertiles, or the highest quartiles as the cutoff values. The highest prognostic power was obtained when S-VEGF and S-bFGF were examined as a combination. Patients who had both S-VEGF and S-bFGF within the highest quartiles had only a 21% 5-year survival rate in contrast to a 64% 5-year survival rate among patients with both factors within the 3 lowest quartiles (P &lt; .0001). Simultaneous elevation of S-VEGF and S-bFGF was associated with poor survival in different grades of lymphomas and in the largest histologic subgroup, the large-cell diffuse and immunoblastic lymphomas. S-VEGF (relative risk [RR], 1.83; P = .019) and S-bFGF (RR, 2.02; P = .0049) had independent influences on survival in multivariate models when tested together with the components of the International Prognostic Index (IPI). Patients with both S-VEGF and S-bFGF within the highest quartiles had nearly 3 times higher risk for death (RR, 2.90; 95% confidence interval [CI], 1.56-5.40;P = .0008) than the rest of the patients. This RR was higher than the relative risks associated with any of the components of the IPI in the same model. The authors conclude that the combination of S-VEGF and S-bFGF is a powerful prognostic variable in NHL.
Following polymerization kinetics of multifunctional acrylates in real time by fluorescence probe methodology (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFollowing polymerization kinetics of multifunctional acrylates in real time by fluorescence probe methodologyJerzy Paczkowski and D. C. NeckersCite this: Macromolecules 1992, 25, 2, 548–553Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ma00028a009https://doi.org/10.1021/ma00028a009research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of Cytochrome P450 Genes Encoding Enzymes Active in the Metabolism of Tamoxifen in Human Uterine Endometrium (1998)

Long-term tamoxifen therapy is associated with increased risk of uterine endometrial cancer and benign alterations. Tamoxifen is metabolized to reactive intermediates by endometrial tissue, and tamoxifen therapy-induced DNA adducts have been found in human endometrium. Since metabolic activation is often catalyzed by cytochrome P450 (CYP) enzymes, the expression profile of individual xenobiotic-metabolizing CYP genes was studied in human uterine endometrium by reverse transcriptase-polymerase chain reaction. The following CYP mRNAs were detected: CYP2B6, CYP2C, CYP2E1, CYP3A4, CYP3A5, CYP4B1, and CYP11A. Amplification of CYP1A1, CYP1A2, CYP2A6, CYP2D6, CYP2F1, CYP3A7, and CYP19 was not found. CYP3A5 and CYP4B1 transcripts were found only in samples from premenopausal women. These data suggest that the human endometrial epithelium has the potential of producing CYP enzymes known to generate genotoxic intermediates from tamoxifen and metabolites that affect oestrogen receptors.
Engineering Vascularized Bone: Osteogenic and Proangiogenic Potential of Murine Periosteal Cells (2012)

One of the key challenges in bone tissue engineering is the timely formation of blood vessels that promote the survival of the implanted cells in the construct. Fracture healing largely depends on the presence of an intact periosteum but it is still unknown whether periosteum-derived cells (PDC) are critical for bone repair only by promoting bone formation or also by inducing neovascularization. We first established a protocol to specifically isolate murine PDC (mPDC) from long bones of adult mice. Mesenchymal stem cells were abundantly present in this cell population as more than 50% of the mPDC expressed mesenchymal markers (CD73, CD90, CD105, and stem cell antigen-1) and the cells exhibited trilineage differentiation potential (chondrogenic, osteogenic, and adipogenic). When transplanted on a collagen-calcium phosphate scaffold in vivo, mPDC attracted numerous blood vessels and formed mature bone which comprises a hematopoiesis-supportive stroma. We explored the proangiogenic properties of mPDC using in vitro culture systems and showed that mPDC promote the survival and proliferation of endothelial cells through the production of vascular endothelial growth factor. Coimplantation with endothelial cells demonstrated that mPDC can enhance vasculogenesis by adapting a pericyte-like phenotype, in addition to their ability to stimulate blood vessel ingrowth from the host. In conclusion, these findings demonstrate that periosteal cells contribute to fracture repair, not only through their strong osteogenic potential but also through their proangiogenic features and thus provide an ideal cell source for bone regeneration therapies.
Frequency-Agile Coplanar-Waveguide-Fed Miniaturized Helical Resonator Filters (2019)

A tunable helical resonator filter utilizing varactor diodes is presented for the first time. Coplanar waveguides are employed as a transition from the ports to the tapped connection, to the helical resonators. This novel configuration not only provides external coupling to the resonators but also allows for two transmission zeros (TZs), one on each side of the passband. A helical resonator with variable capacitors was fabricated and characterized as a building block for the proposed filter. The tunable helical resonator yields a measured unloaded quality factor (Q) of 192-227 with a variable center frequency of 150-230 MHz. Also, a 4% second-order bandpass filter was designed, fabricated, and tested to demonstrate the concept. The measured second-order bandpass filter achieves a variable center frequency of 170-230 MHz with an insertion loss of 0.9-1.3 dB.
Broad‐Spectral‐Response Nanocarbon Bulk‐Heterojunction Excitonic Photodetectors (2013)

High-performance broad-spectrum nanocarbon bulk-heterojunction photovoltaic photodetectors are reported. These reported photodetectors consist of a semiconducting single-walled carbon nanotube (s-SWCNT) and a PC71 BM blended active layer. Magnetic-field effects and the chirality of the s-SWCNTs play an important role in controlling the photoresponse time and photocurrent improvement.