gebhart/patrepeval huggingface dataset:
Preclinical development of ARRY-142886, a potent and selective MEK inhibitor (2004)

3890 MEK is a critical kinase in the signal transduction pathway for many growth factor receptors, including EGF-R, IGF-1R and PDGF-R, which provide growth signals to cancer cells. It is downstream of Ras and Raf proteins that are often mutated and abnormally active in cancer. The MEK inhibitor, ARRY-142886, inhibits the proliferation of several human cancer cell lines in culture, including HT29, Malme-3M, SK-MEL-28, MIA PaCa2, and SK-MEL-2. We have confirmed in vivo efficacy of ARRY-142886 in several tumor xenograft models in mice. In an HT29 human colon carcinoma model, dose-dependent inhibition of tumor growth was observed. Doses of 10 mg/kg, BID, PO resulted in greater than 50% tumor growth inhibition. Of note, in the BxPC3 human pancreatic carcinoma model, tumor regression was seen at doses of 10, 25 or 50 mg/kg, BID, PO. In these studies, tumors were excised and analyzed for ERK phosphorylation. Consistent with ARRY-142886’s mechanism of action, tumor growth inhibition correlated with decreased phospho-ERK levels in tumors. The effects of ARRY-142886 on tumor re-growth were also evaluated in a BxPC3 model. After three weeks of dosing (25 or 50 mg/kg, BID, PO), treatment was stopped for one week, during which time tumor growth resumed. Mice were then treated for an additional 3 weeks at the same doses. ARRY-142886 was effective in reducing tumor size and maintaining tumor growth inhibition of the re-established tumors, demonstrating that the tumors were still sensitive to ARRY-142886 after a dosing holiday. ARRY-142886 has shown efficacy in other xenograft models including MIA PaCa2, A549, Colon26, PANC-1, LoVo, Calu6, HCT116, MDA-MB-231, ZR-75-1 and LOX. These studies confirm that ARRY-142886 can block ERK phosphorylation in tumors and has broad anti-tumor effects in vivo.
[(SeO)4P8W48O184]32–: a Tetraselenite‐Embedded Derivative of the Cyclic 48‐Tungsto‐8‐Phosphate (2018)

The tetraselenite‐incorporated 48‐tungsto‐8‐phosphate [(SeO) 4 P 8 W 48 O 184 ] 32– ( Se 4 P 8 W 48 ) has been synthesized by treating SeO 2 with the superlacunary, macrocyclic polyanion precursor [P 8 W 48 O 184 ] 40– ( P 8 W 48 ) in aqueous solution. Single crystal X‐ray diffraction analysis was carried out on K 26 Li 6 [(SeO) 4 P 8 W 48 O 184 ] · 98H 2 O [ KLi‐Se 4 P 8 W 48 , monoclinic space group C 2/ m, a = 35.3618(9) Å; b = 21.7869(6) Å; c = 24.6187(7) Å; β = 132.5822(15) °; V = 13965.4(7) Å 3 ; Z = 2]. The polyanion Se 4 P 8 W 48 contains four SeO 3 2– groups, adopting a trigonal‐pyramidal coordination geometry, grafted on the rim of the central cavity of P 8 W 48 . These four Se atoms are arranged in a coplanar fashion that is perpendicular to the main plane of P 8 W 48 , resulting in an overall D 2 h point group symmetry for Se 4 P 8 W 48 . The KLi‐Se 4 P 8 W 48 bulk material was characterized by X‐ray diffraction, infrared, UV/Uis, and NMR spectroscopy, as well as thermogravimetric and elemental analysis.
"For no other offence but proximity": Stuff happens to the Queen (2008)

The emergent trend of depicting sitting politicians and heads of state in mainstream British drama and film is considered through a reading of David Hare's play, Stuff Happens (2006), and Stephen Frear's film, The Queen (2006). These are seen as contemporary dramatisation(s) of the erosion of the gap between the public and private lives of the protagonists: private lives can now be the subject of plays or films only when and because public personas have been diminished. No longer held in high regard, the 'proximity' of public figures enables the dramatisation of private scenes which would have previously been unthinkable.
Real-Time In Vivo Imaging of Human Liver Vasculature Using Coherent Flow Power Doppler: A Pilot Clinical Study (2021)

Power Doppler (PD) is a commonly used technique for flow detection and vessel visualization in radiology clinics. Despite its broad set of applications, PD suffers from multiple noise sources and artifacts, such as thermal noise, clutter, and flash artifacts. In addition, a tradeoff exists between acquisition time and Doppler image quality. These limit the ability of clinical PD imaging in deep-lying and small-vessel detection and visualization, particularly among patients with high body mass indices (BMIs). To improve the Doppler vessel detection, we have previously proposed coherent flow PD (CFPD) imaging and demonstrated its performance on porcine vasculature. In this article, we report on a pilot clinical study of CFPD imaging on healthy human volunteers and patients with high BMI to assess the clinical feasibility of the technique in liver imaging. In this study, we built a real-time CFPD imaging system using a graphical processing unit (GPU)-based software beamformer and a CFPD processing module. Using the real-time CFPD imaging system, the liver vasculature of 15 healthy volunteers with normal BMI below 25 and 15 patients with BMI greater than 25 was imaged. Both PD and CFPD image streams were produced simultaneously. The generalized contrast-to-noise ratio (gCNR) of the PD and CFPD images was measured to provide the quantitative evaluation of image quality and vessel detectability. Comparison of PD and CFPD image shows that gCNR is improved by 35% in healthy volunteers and 28% in high BMI patients with CFPD compared to PD. Example images are provided to show that the improvement in the Doppler image gCNR leads to greater detection of small vessels in the liver. In addition, we show that CFPD can suppress in vivo reverberation clutter in clinical imaging.
Autobus with four minutes recharges at the ends of the line (2012)

International audience
Appendix 5: Reference Fields and Scattering Matrices for Multimodal Rectangular Waveguide Filters (2007)

This appendix contains sections titled: Reference Electric and Magnetic Fields Scattering Matrix of Multiple Waveguide Sections Scattering Matrix for Discontinuity in Dielectric Permittivity Scattering Matrix for Discontinuity in Waveguide Dimensions References
Electron-energy-loss spectroscopy of carbon nanometer-size tubes (1993)

Electron-energy-loss spectra from individual carbon nanometer-size tubes are presented. The bulk plasmon-loss (\ensuremath{\sigma}+\ensuremath{\pi}) peak seen at \ensuremath{\sim}27 eV in graphite undergoes systematic shift towards lower energy, as the tube size is reduced. The low-energy-loss plasmon (\ensuremath{\sim}7 eV) due to the \ensuremath{\pi} electrons is weak and not well defined for very small tubes. It is seen that the peak shift depends on the number of layers that constitute the tubes and the tube diameter. The carbon K edge from nanometer-size tubes shows similar energy-loss features as in graphite. Thin amorphouslike glassy structures formed in the carbon soot also show shifts of peaks compared to graphite and graphitelike glassy structures. We conclude that the \ensuremath{\pi} electrons tend to behave less delocalized in small tubes, due to the curvature-induced strain, and contribute less to the collective excitations in structures with poorly developed c-plane ordering.
Table S1 from Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy (2023)

&lt;p&gt;Summary of drug panels and peritonoid genomic information&lt;/p&gt;
Query optimization for CODASYL database systems (1982)

One of the tasks of MULTIBASE, a system for integrated access to heterogeneous distributed databases, is to present a high-level query interface to navigational systems such as CODASYL. The interface compiles queries into efficient programs that implement the queries. The principal problem in constructing such an interface is access path optimization, i.e., the selection of an optimal sequence of access paths that must be traversed to process a given query. This paper identifies a class of queries for which efficient programs can be synthesized. It characterizes the strategies for processing a given query, and shows how to synthesize a program for implementing each strategy. It develops a model for estimating the cost of executing a program, and uses this model to find the optimal strategy for processing a given query.
Interpretation based on stochastic geometry of homodyned-K distribution scatterer clustering parameter for quantitative ultrasound imaging (2020)

The homodyned K-distribution has been proposed as a general statistical model for the echo envelope of ultrasound radiofrequency signals. It has been stated that its scatterer clustering parameter is equal to the number of scatterers per resolution cell. In the present work, we conjectured that this parameter is the ratio of the number of scatterers per resolution cell to the packing factor, this formulation taking into account the spatial organization of scatterers. The goal of this work was to assess this hypothesis on simulated ultrasound images. Simulations with number of scatterers per resolution cell varying from 1 to 11 by steps of 2, and packing factor varying within 2 and 9, suggest that the hypothesis is valid.
Environmental and Energy Performance of Offshore Aquaculture Systems Incorporating with Ocean Renewable Energy Sources (2023)

Aquaculture industry continues to grow globally as an increasing need for global food access and security.The corresponding operations for aquaculture are moving to farther offshore areas, pursuing greater productivity.Several new offshore aquaculture systems incorporating with ocean renewable energy sources, have emerged in recent years.However, the environmental and economic effects of these offshore aquaculture systems have not been systematically performed up to now.In this study, a wave powered offshore aquaculture platform, Penghu, was taken as a case study to evaluate the environmental and economic performance using life cycle assessment (LCA) and life cycle cost assessment (LCCA).Additionally, the energy performance of power system on the platform was also discussed.Results showed that the carbon footprint of the aquaculture platform was 2,307 t CO 2 -eq.The production operations on the platform achieved zerocarbon emissions, due to all production facilities were entirely powered by renewable energy.Additionally, the energy payback time of the power system was about 0.8 years.The energy payback ratio is 25.23.The LCCA analysis indicated that the profits from this new offshore aquaculture platform is substantial, although the total cost is much higher than that of the conventional system.
Direct Spectrophotometric Analysis of Cr(VI) Using a Liquid Waveguide Capillary Cell (2008)

Hexavalent chromium Cr(VI) is a notorious ground water contaminant toxic to humans and animals. Assessment of an exposure risk for aquatic receptors necessitates frequent Cr(VI) concentration data from a range of surface and groundwater locations at Cr(VI) contamination sites. In this work, we demonstrate that enhanced ultraviolet-visible (UV-vis) spectroscopy using a liquid waveguide capillary cell (LWCC) offers an easy-to-use and economical methodology for the determination of chromate anion CrO(4)(2-) in Hanford natural waters without chemical pretreatment and generation of hazardous waste. Direct determination of CrO(4)(2-) in actual surface and ground water samples with the complexities of competing ions, dissolved organics, and other potential interfering agents was achieved by measuring the chromate optical absorbance at 372 nm. For a 100 cm path length LWCC, the detection limit for chromate was found to be as low as 0.073 ppb. A quantitative relationship between the intensity of the absorbance signal and water pH allowed for the straightforward calculation of total Cr(VI) content in natural water. The described method is applicable for in-field monitoring of Cr(VI) in environmental water samples at trace levels.
Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways (1997)

Tumor necrosis factor alpha (TNFalpha) is a cytokine implicated in the pathogenesis of numerous chronic and acute inflammatory conditions. In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. The intradermal injection of recombinant human TNFalpha induced a slowly developing, dose-dependent accumulation of 111In-eosinophils in rat skin that was maximal at the dose of 10(-11) mol/site. Coadministration of TNFalpha with the soluble TNFalpha receptor (p55)-IgG fusion protein (TNFR-IgG) totally inhibited the 111In-eosinophil accumulation induced by the cytokine. The TNFalpha-induced 111In-eosinophil accumulation was not affected after pretreatment of rats with the platelet-activating factor (PAF) receptor antagonist UK-74,505 or the antihuman interleukin-8 monoclonal antibody (MoAb) DM/C7. In contrast, the intravenous administration of an anti-alpha4 integrin MoAb, HP2/1 (3.5 mg/kg), or an anti-VCAM-1 MoAb, 5F10 (2 mg/kg), greatly inhibited the 111In-eosinophil accumulation induced by TNFalpha (the responses detected at 10(-11) mol/site were inhibited by 78% and 50%, respectively). These results show that TNFalpha is an effective inducer of eosinophil accumulation in vivo, with this response being dependent on an interaction between alpha4 integrins and VCAM-1.
Development of High-Performance Solar Cells for the Jupiter and Saturn Environments (2018)

Many of the mission targets that NASA and the planetary-science community are interested in are located in deep space, in the 5-10AU range. This provides compelling motivation to develop solar cells and arrays that are highly efficient in low irradiance low temperature (LILT) environments. We give several examples of the iterative process our team has employed to develop cell designs that optimize the performance at LILT. We also provide results on advanced-architecture devices that have already demonstrated very high efficiencies in the Jupiter and Saturn LILT and radiation environments, specifically fourjunction inverted metamorphic and triple-junction upright metamorphic solar cells, respectively.
Neuroactive Steroids and Ethanol (2005)

This article presents the proceedings of a symposium presented at the International Society for Biomedical Research on Alcoholism 12th World Congress on Biomedical Alcohol Research, held in Heidelberg/Mannheim, Germany, from September 29 to October 2, 2004. The organizer and chairperson was Robert H. Purdy. The presentations were (1) Fetal ethanol‐induced increase in brain levels of pregnenolone sulfate, by C. Fernando Valenzuela; (2) GABAergic neuroactive steroids after ethanol self‐administration and relapse, by Patricia H. Janak; (3) Neuroactive steroid modulation of ethanol intake patterns in C57BL/6J mice, by Deborah A. Finn; (4) Role of neurosteroids in ethanol dependence and GABA A receptor plasticity, by Giovanni Biggio; and (5) Alcohol and neuroactive steroid interactions in the menstrual cycle, by Torbjörn Bäckström.
Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2 (2007)

Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown that activated protein C (APC) exhibits anti-inflammatory properties and modulates endothelial function. Therefore, we investigated the effect of APC on ARF in a rat model of endotoxemia. Rats subjected to lipopolysaccharide (LPS) treatment exhibited ARF as illustrated by markedly reduced peritubular capillary flow and increased serum blood urea nitrogen (BUN) levels. Using quantitative two-photon intravital microscopy, we observed that at 3 h post-LPS treatment, rat APC (0.1 mg/kg iv bolus) significantly improved peritubular capillary flow [288 +/- 15 microm/s (LPS) vs. 734 +/- 59 microm/s (LPS+APC), P = 0.0009, n = 6], and reduced leukocyte adhesion (P = 0.003) and rolling (P = 0.01) compared with the LPS-treated group. Additional experiments demonstrated that APC treatment significantly improved renal blood flow and reduced serum BUN levels compared with 24-h post-LPS treatment. Biochemical analysis revealed that APC downregulated inducible nitric oxide synthase (iNOS) mRNA levels and NO by-products in the kidney. In addition, APC modulated the renin-angiotensin system by reducing mRNA expression levels of angiotensin-converting enzyme-1 (ACE1), angiotensinogen, and increasing ACE2 mRNA levels in the kidney. Furthermore, APC significantly reduced ANG II levels in the kidney compared with the LPS-treated group. Taken together, these data suggest that APC can suppress LPS-induced ARF by modulating factors involved in vascular inflammation, including downregulation of renal iNOS and ANG II systems. Furthermore, the data suggest a potential therapeutic role for APC in the treatment of ARF.
Acquisition Performance of Walsh-Hadamard Code Based Orthogonal Modulation Signal for Satellite Navigation Signal Applications (2018)

A signal acquisition scheme for a Walsh - Hadamard (WH) code-based orthogonal modulation signal is proposed for the application to the satellite navigation signals. The proposed scheme is a correlator that takes the advantage of the Fast Walsh - Hadamard Transform (FWHT) structure for the symbol demodulation of WH code. The proposed method’s signal acquisition performance is simulated in terms of false alarm probability and missing probability, and it is confirmed that a performance improvement of more than 1 dB can be achieved over the conventional LEX signal in the additive white Gaussian noise (AWGN) channel.
Essential oil of some seasonal flowering plants grown in Saudi Arabia (2011)

The constituents of the essential oils of Rumex vesicarius, Erucaria hispanica, Schimpera arabica, Savignya parviflora, Horwoodia dicksoniae, Sisymbrium irio, Plantago amplexicaulis, Plantago boissieri, Arnebia linearifolia, Foeniculum vulgare, Trigonella hamosa, Lotus halophilus, Reseda muricata, Cenchrus ciliaris is reported. These oils were analyzed by GC/MS and most of them are being studied for the first time.
Ion energies in EUV induced plasma: Measuring methods (2014)

No abstract.
Investigations of Electronic Energy Transfer Dynamics in Multiporphyrin Arrays (1999)

A study of the dynamics of electronic energy transfer (EET) in arrays containing three, four, and six tetraphenylporphine units connected with phenylethynyl spacers is reported. For arrays containing the same chromophores, the EET rate constant was determined from the reorientational dynamics of the transition dipole using the crossed grating technique. EET time constants ranging from 150 ps up to 33 ns were measured, depending on the distance between the chromophores and on the metal ion complexed in the porphyrins. For the trimeric planar arrays, the interchromophoric distance varies by a factor of 2, while the ratio of the through space to through bond distances is constant. By comparing the measured EET rate constants with those calculated using Förster theory, the contributions of the Coulombic, through space, mechanism and of the exchange, through bond, mechanism could be estimated. For the arrays with the shortest spacer (through space distance of 23 Å), EET occurs through both exchange and Coulombic interactions with a ratio of about 3:1. This ratio increases up to about 10 as the distance is increased to 34.5 Å. At 46.5 Å, the ratio decreases and it appears that the Coulombic interaction becomes the dominant mechanism at longer distances. In the tetrahedral compound, the presence of a central saturated carbon strongly alters the electronic conducting properties of the spacer and makes the exchange mechanism inoperative.
INVESTIGATION OF IMPINGEMENT HEAT TRANSFER COEFFICIENT AT HIGH TEMPERATURES (2002)

ABSTRACT Very little information exists for the impingement heat transfer coefficient at high temperatures. All available empirical correlations are mainly based on experiments conducted at relatively low impingement temperatures, and thus cannot describe the heat transfer characteristics of the impingement air at high temperatures with sufficient accuracy. A comprehensive study of the impingement heat transfer coefficient at high temperatures is carried out and presented in this paper. The aim of the study is to give a summary of the experimental results of the impingement heat transfer covering a large impingement air temperature range from 100 to 700°C. Heat transfer measurements were carried out on a laboratory-scale test rig. The main parts of the rig were a fan, a gas burner for air heating, a heavily insulated nozzle array with 300 × 500 mm impingement surface, a 40 mm thick and 300 × 500 mm sized aluminium plate for determination of heat transfer, and a data acquisition system. The heat transfer rate was determined from the heat-up rate of the aluminium plate due to the high temperature jet impingement.
Time-Resolved Electron Paramagnetic Resonance Study of Rhodium(III) Corrole Excited States (2010)

Photoexcited states of three Rh(III) 5,10,15-tris(pentafluorophenyl)corroles coordinated by different axial ligands; namely, triphenylphosphine P(C(6)H(5))(3) group (1), pyridine C(6)H(5)N group (2), and two pyridine groups (3) were studied by X- and Q-band time-resolved electron paramagnetic resonance (TREPR) in frozen toluene and liquid crystal E-7. Transient mutations were utilized to identify multiplicity of the detected paramagnetic species. The spectra of 1 and 2 were assigned to triplet ((3)pipi*) states, while contributions of triplet ((3)dd and charge transfer (3)CT) and quintet ((5)dd) states were revealed in the spectrum of 3. The results are interpreted in terms of a peculiar nature of transition metal complexes with the unfilled d-shell, where close lying electronic states of different multiplicities may be mixed through configurational, spin-orbit, and vibronic coupling. From the EPR spectra, the spin-orbit coupling constant was estimated to be about 25 cm(-1). It is shown that different axial ligation of complexes shifts the relative energy of the excited states and, consequently, leads to population of different states. Plausible explanations of the effects governing unusual spectral and dynamic parameters of the photoexcited Rh corrole complexes are presented.
Synthesis of a Carbohydrate-Derived Hydroxamic Acid Inhibitor of the Bacterial Enzyme (LpxC) Involved in Lipid A Biosynthesis (2003)

[reaction: see text] The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl]-GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized using two different routes. Compound 8 exhibits activity toward LpxC enzymes from a wider spectrum of bacterial species than any of the previously reported hydroxamic acid inhibitors.
Is There Chronic Brain Damage in Retired NFL Players? Neuroradiology, Neuropsychology, and Neurology Examinations of 45 Retired Players (2014)

These results need to be reconciled with the prevailing view that a career in football frequently results in chronic brain damage.