gebhart/patrepeval huggingface dataset:
Data from Cross-dressing of CD8α<sup>+</sup> Dendritic Cells with Antigens from Live Mouse Tumor Cells Is a Major Mechanism of Cross-priming (2023)

&lt;div&gt;Abstract&lt;p&gt;Live cells are the most abundant sources of antigen in a tumor-bearing host. Here, we used live tumor cells as source of antigens to investigate the mechanism underlying their immunogenicity in murine tumor models. The live tumor cells were significantly more immunogenic than irradiated or apoptotic tumor cells. We examined the interaction of live and apoptotic tumor cells with major subsets of antigen-presenting cells, i.e., CD8α&lt;sup&gt;+&lt;/sup&gt; dendritic cells (DC), CD8α&lt;sup&gt;−&lt;/sup&gt; DCs, plasmacytoid DCs, and CD169&lt;sup&gt;+&lt;/sup&gt; macrophages at skin draining lymph nodes. The CD8α&lt;sup&gt;+&lt;/sup&gt; DCs captured cell-associated antigens from both live and apoptotic tumor cells, whereas CD169&lt;sup&gt;+&lt;/sup&gt; macrophages picked up cell-associated antigens mostly from apoptotic tumor cells. Trogocytosis and cross-dressing of membrane-associated antigenic material from live tumor cells to CD8α&lt;sup&gt;+&lt;/sup&gt; DCs was the primary mechanism for cross-priming of tumor antigens upon immunization with live cells. Phagocytosis of apoptotic tumor cells was the primary mechanism for cross-priming of tumor antigens upon immunization with apoptotic or irradiated cells. These findings clarify the mechanism of cross-priming of cancer antigens by DCs, allowing for a greater understanding of antitumor immune responses.&lt;/p&gt;&lt;/div&gt;
Metal-nitride-oxide-semiconductor light-emitting devices for general lighting (2011)

The potential for application of silicon nitride-based light sources to general lighting is reported. The mechanism of current injection and transport in silicon nitride layers and silicon oxide tunnel layers is determined by electro-optical characterization of both bi- and tri-layers. It is shown that red luminescence is due to bipolar injection by direct tunneling, whereas Poole-Frenkel ionization is responsible for blue-green emission. The emission appears warm white to the eye, and the technology has potential for large-area lighting devices. A photometric study, including color rendering, color quality and luminous efficacy of radiation, measured under various AC excitation conditions, is given for a spectrum deemed promising for lighting. A correlated color temperature of 4800K was obtained using a 35% duty cycle of the AC excitation signal. Under these conditions, values for general color rendering index of 93 and luminous efficacy of radiation of 112 lm/W are demonstrated. This proof of concept demonstrates that mature silicon technology, which is extendable to low-cost, large-area lamps, can be used for general lighting purposes. Once the external quantum efficiency is improved to exceed 10%, this technique could be competitive with other energy-efficient solid-state lighting options.
The effect of vacuum ultraviolet irradiation on the time-dependent dielectric breakdown of organosilicate dielectrics (2016)

In this work, the effect of vacuum ultraviolet (VUV) exposure on the time-dependent dielectric breakdown (TDDB) properties of porous low-k films was investigated. Synchrotron irradiation was used to simulate the VUV photon irradiation from processing plasmas without any particle flux. The synchrotron flux varies with the wavelength, so the irradiation time was chosen to produce the same fluence at various photon energies. The deterioration of TDDB and generation of negative mobile charge were observed in the film after exposure to the VUV photons with 9 eV or higher energy. These effects were not observed in the films exposed with 7-eV photon energies or less. The creation of paramagnetic defects was observed with the ESR measurement and believed to be the reason for TDDB degradation. Depletion of carbon and breakage and rearrangement of the Si-O-Si structure were observed and believed to be the reason for mobile charge generation and the change in TDDB, chemical, and mechanical properties.
Modifications of a Two Stage Centrifugal Compressor for the Volute and Vaneless Diffuser Study (2001)

Abstract The objective of this work was to establish an advanced testing facility for studying the flow structure and loss mechanism in a single stage centrifugal compressor. A Trane’s CVHF 1280, two stage centrifugal compressor was modified to a single stage for laboratory environment. This modification included new fluid medium, driving motor, inlet and outlet designs. In this study, experiments were performed in order to evaluate the performance of the vaneless diffuser and volute. However, the modifications enable the flow structure investigation in all components of the compressor as well. In addition the testing facility would accommodate installation of the rest of the unit for investigation of the flow in the vaned diffuser and return channel of the two-stage compressor in the laboratory environment. Experiments were performed in three speeds and eight mass flow rates per speed. Static and total pressures were measured at the inlet and outlet of the stage. Static pressure distributions were mapped on the vaneless diffuser and volute casings. These data evaluates the characteristics of these components after the modifications.
ChemInform Abstract: THE REGIOSPECIFIC TOTAL SYNTHESIS OF LAVENDAMYCIN METHYL ESTER (1984)

Abstract 3‐Methoxyaminobenzaldehyd (I) kondensiert mit Brenztraubensäure (II) zur Chinolincarbonsäure (III), die in Gegenwart von Carbodiimid zum Amid (V) kondensiert und mit Polyphosphat zum β‐(′arbolin (VI) cyclisiert werden kann.
Development of Novel Drugs That Target Coactivation Sites of the Androgen Receptor for Treatment of Antiandrogen-Resistant Prostate Cancer (2013)

Abstract : Interest in developing androgen receptor (AR) inhibitors with novel mechanism of action is slowly increasing since commercial anti-androgens (Bicalutamide, Flutamide, Nilutamide and Enzalutamide) face therapeutic limitations. Current therapies fail over a period of time because they all target hormone binding pocket on AR to which the receptor has already developed effective resistance mechanisms. One of the promising strategies to combat drug resistance is to develop the inhibitors that target an alternative binding pocket of the AR, called Binding Function 3 (BF3). In the current study, we report indole chemical series, identified through systematic in silico screen, as leading AR BF3 inhibitors. The most potent inhibitor (compound VPC-13566) demonstrated excellent anti-androgen potency, anti-PSA activity and abrogates androgen-induced proliferation of LNCaP and Enzalutamide-resistant prostate cancer cell lines. Moreover, it demonstrated clear reduction of tumour growth in tumor xenograft models in mice. Based on these results new derivatives have been developed to improve stability and better efficacy in in-vivo models. These findings provide evidence that targeting AR BF3 pocket using small molecule inhibitors is a viable therapeutic approach for patients with advanced prostate cancer.
Statistical behaviour of the effective rain height in the tropics (1995)

The rain height is an important parameter for the prediction of rain attenuation and hydrometeor scattering that occur in satellite radio links. For temperate climates, where rain is mostly stratiform and widespread, it is usually assumed that rain cells extend vertically up to the height of the 0/sup 0/ isotherm. To take into account the variations of rain intensity in the cell, most methods for slant-path rain attenuation prediction assume a rain height that can be even lower than the 0/sup 0/ isotherm height. In tropical and equatorial climates, on the other hand, rain events are usually associated with convective cells, which vertical dimension can reach altitudes much higher than the 0/sup 0/ isotherm. The statistical behaviour of the effective rain height in such regions is investigated based on data obtained in concurrent measurements of point rainfall rate and radiometric attenuation at 12 GHz.
MSE Based Optimization of Multiuser MIMO MAC with Partial CSI (2006)

This paper studies the optimal transmission design for multiple antenna multiple access channels with linear MMSE receiver at the base station and partial channel state information at the mobiles. The performance criterium for optimization is based on a Schur-concave function that works on the average individual MSEs of all users. The optimal beamforming matrix of each user corresponds to the eigenvector matrix of his channel correlation matrix. The remaining power allocation problem can be solved at reduced complexity. It is also direct to extend the results to Schur-convex functions. The results are illustrated by numerical simulations.
On the non-suitability of non-volatility (2015)

For many emerging and existing architectures, NAND flash is the storage media used to fill the cost-performance gap between DRAM and spinning disk. However, while NAND flash is the best of the available options, for many workloads its specific design choices and trade-offs are not wholly suitable. One such workload is long-running scientific applications which use checkpoint-restart for failure recovery. For these workloads, HPC data centers are deploying NAND flash as a storage acceleration tier, commonly called burst buffers, to provide high levels of write bandwidth for checkpoint storage. In this paper, we compare the costs of adding reliability to such a layer versus the benefits of not doing so. We find that, even though NAND flash is non-volatile, HPC burst buffers should not be reliable when the performance overhead of adding reliability is greater than 2%.
<title>Advances in low-cost long-wave infrared polymer windows</title> (1999)

Recent improvements in engineered polymeric material compositions and advances in processing methodologies developed and patented at Raytheon Systems Company have produced long wave IR windows at exceptionally low costs. These UV stabilized, high strength windows incorporating subwavelength structured antireflection surfaces are enabling IR imaging systems to penetrate commercial markets and will reduce the cost of systems delivered to the military. The optical and mechanical properties of these windows will be discussed in detail with reference to the short and long-term impact on military IR imaging systems.
FFTS with near-optimal memory access through block data layouts (2014)

Fast Fourier transform algorithms on large data sets achieve poor performance on various platforms because of the inefficient strided memory access patterns. These inefficient access patterns need to be reshaped to achieve high performance implementations. In this paper we formally restructure 1D, 2D and 3D FFTs targeting a generic machine model with a two-level memory hierarchy requiring block data transfers, and derive memory access pattern efficient algorithms using custom block data layouts. Using the Kronecker product formalism, we integrate our optimizations into Spiral framework. In our evaluations we demonstrate that Spiral generated hardware designs achieve close to theoretical peak performance of the targeted platform and offer significant speed-up (up to 6.5x) compared to naive baseline algorithms.
Water‐Soluble Organometallics in the Environment (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
[18F] FDG Positron Emission Tomography (PET) Tumor and Penumbra Imaging Features Predict Recurrence in Non–Small Cell Lung Cancer (2019)

We identified computational imaging features on 18F-fluorodeoxyglucose positron emission tomography (PET) that predict recurrence/progression in non-small cell lung cancer (NSCLC). We retrospectively identified 291 patients with NSCLC from 2 prospectively acquired cohorts (training, n = 145; validation, n = 146). We contoured the metabolic tumor volume (MTV) on all pretreatment PET images and added a 3-dimensional penumbra region that extended outward 1 cm from the tumor surface. We generated 512 radiomics features, selected 435 features based on robustness to contour variations, and then applied randomized sparse regression (LASSO) to identify features that predicted time to recurrence in the training cohort. We built Cox proportional hazards models in the training cohort and independently evaluated the models in the validation cohort. Two features including stage and a MTV plus penumbra texture feature were selected by LASSO. Both features were significant univariate predictors, with stage being the best predictor (hazard ratio [HR] = 2.15 [95% confidence interval (CI): 1.56-2.95], <i>P</i> < .001). However, adding the MTV plus penumbra texture feature to stage significantly improved prediction (<i>P</i> = .006). This multivariate model was a significant predictor of time to recurrence in the training cohort (concordance = 0.74 [95% CI: 0.66-0.81], <i>P</i> < .001) that was validated in a separate validation cohort (concordance = 0.74 [95% CI: 0.67-0.81], <i>P</i> < .001). A combined radiomics and clinical model improved NSCLC recurrence prediction. FDG PET radiomic features may be useful biomarkers for lung cancer prognosis and add clinical utility for risk stratification.
Phase III trial to confirm the superiority of pelvic and para-aortic lymphadenectomy to pelvic lymphadenectomy alone for endometrial cancer: Japan Clinical Oncology Group Study 1412 (SEPAL-P3) (2017)

To prospectively investigate the survival benefit of para-aortic lymphadenectomy, we launched a new study, the JCOG1412. This is a randomized Phase III trial to confirm the superiority of pelvic and para-aortic lymphadenectomy to pelvic lymphadenectomy alone. Patients corresponding to possible FIGO Stage IB, II, IIIA, IIIB, and a part of IIIC1 are eligible for the first registration before surgery. Next, those patients without evidence of para-aortic lymph node metastasis and multiple pelvic lymph node metastasis during surgery will be included in the second registration and randomized to either the pelvic lymphadenectomy alone arm or the pelvic and para-aortic lymphadenectomy arm. After the initial surgery, patients with post-operative recurrence risks receive adjuvant chemotherapy. The primary endpoint is overall survival. Secondary endpoints include relapse-free survival, short-term surgical outcomes, adverse events related to adjuvant chemotherapy and recurrence patterns. This trial has been registered at the UMIN Clinical Trials Registry [http://www.umin.ac.jp/ctr/index.htm] as UMIN000025399.
Developmental and regional regulation of rab3: A new brain specific “ras‐like” gene (1989)

Recently, the expression of rab3, a new ras-like gene, has been shown to be restricted to brain tissues (Olofsson et al., 1988). This finding has prompted us to study the expression of rab3 in different brain regions of the developing mouse. The two transcripts corresponding to rab3 (1.8 and 1.3 kb) were first detected in the brains of E13 mouse embryos and were not randomly distributed. Highest levels were found in the mesencephalon, followed by the cortex, striatum, cerebellum, and brain stem in that order. In vitro, the expression of the 1.8-kb transcript was neuron specific, whereas the small transcript was present in neurons and astrocytes. This is the first report showing developmental and regional regulation of a nervous system-restricted ras-like gene. Based on the homologies found between the rab genes and YPT1 or sec-4, we suggest that the physiological role of rab3 might be related to the stabilization of the neuronal cytoskeleton or to post-Golgi vesicle transport and fusion.
HLA‐B27 screening by flow cytometry (1995)

A flow cytometric assay for lymphocyte HLA-B27 expression using a two-color direct immunofluorescent assay was compared to traditional microlymphocytotoxicity testing on 209 clinical samples. For the flow cytometric assay, whole blood was mixed with a monoclonal anti-B27 conjugated to fluorescein-isothiocyanate (FITC) and anti-CD3 conjugated to phycoerythrin (PE). The samples were analyzed with flow cytometry by gating on CD3 positive events and anti-B27 staining intensity was evaluated as median channel fluorescence of the histogram peak. The median channel fluorescence was least with B27 negative and B7 negative samples (84 +/- 17), intermediate with samples that were B27 negative but B7 positive (118 +/- 13), and greatest with samples that were B27 positive (155 +/- 13). In addition to cross-reactivity with the B7 antigen (n = 38), the monoclonal anti-B27 cross-reacted with HLA-B37 positive samples (n = 3) and HLA-B39 positive samples (n = 3). Using a median channel fluorescence cutoff of 136, 39 of the 40 B27 positive samples gave positive results in the flow cytometric assay for a sensitivity of 97.6%. The specificity was 95.9% with 7 false positives of 169 B27 negative samples. The flow cytometric HLA-B27 assay is a convenient, useful screening test. For greatest specificity, samples positive by flow cytometry should be confirmed by conventional microlymphocytotoxicity or by use of other monoclonal antibodies directed against B27.
A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery (2022)

Adenoviruses (Ads) are attractive nonviral vectors and show great potential in cancer gene therapy. However, inherent properties of Ads, including immunogenicity, nonspecific toxicity, and coxsackie and adenovirus receptor (CAR)-dependent cell uptake, limit their clinical use. To surmount these issues, we developed a pH- and glutathione-responsive poly(ethylene glycol)-poly(ꞵ-aminoester)-polyethyleneimine (PPA) for conjugation with Ad. The pH sensitivity of the PPA copolymer was elegantly tuned by substitution with different amino acids (arginine, histidine, and tryptophan), piperazines (Pip1, Pip2, and Pip3), and guanidine residues in the backbone of the PPA conjugate. PPA copolymer was further functionalized with short-chain cross-linker succinimidyl 3-(2-pyridyldithio)propionate) (SPDP) to obtain PPA-SPDP for facile conjugation with Ad. The PPA-conjugated Ad (PPA-Ad) conjugate was obtained by reacting PPA-SPDP conjugate with thiolated Ad (Ad-SH). Ad-SH was prepared by reacting Ad with 2-iminothiolane. The size distribution and zeta potential results of PPA-Ad conjugate showed an increasing trend with an increase in copolymer dose. From in vitro test, it was found that the transduction efficiency of PPA-Ad conjugate in CAR-positive cells (A549 and H460 cells) was remarkably increased at the acidic pH condition (pH 6.2) when compared with PPA-Ad conjugate incubated under the physiological condition (pH 7.4). Interestingly, the increase in transduction efficiency was evidenced in CAR-negative cells (MDA-MB-231 and T24 cells). These results demonstrated that biocompatible and biodegradable PPA copolymers can efficiently cover the surface of Ad and can increase the transduction efficiency, and hence PPA copolymers can be a useful nanomaterial for viral vector delivery in cancer therapy.
P‐153: Color‐Saturated LEDs Based on Colloidal Quantum‐Dot by Improving Charge Injection and Transport Layers (2010)

Abstract We report light‐emitting diodes incorporating colloidal quantum dots as the emitters, which showed saturated red, green and blue colors mostly originating from quantum‐dots (over 99%). They also showed external quantum efficiency of 1.5 % and brightness over 10,000 cd/m 2 , which were achieved by improving charge injection and transport layers.
Label free nano-aptasensor for interleukin-6 in protein-dilute bio fluids such as sweat (2016)

A sub-pM limit of detection label-free sensor is presented for interleukin-6 based on impedimetric measurement of a gold nanoparticle/aptamer-modified electrode in artificial sweat.
Double dipole lithography for 65-nm node and beyond: defect sensitivity characterization and reticle inspection (2004)

Double Dipole Lithography (DDLä) has been demonstrated to be capable of patterning complex 2D devices patterns. [1,2,3] Due to inherently high aerial image contrast from dipole illumination, we have found that it can meet lithography manufacturing requirements, such as line edge roughness (LER), and critical dimension uniformity (CDU), for the upcoming 65nm node using ArF binary chrome masks. For patterning at k1 below 0.35, DDL is one of the promising resolution enhancement techniques (RET), which can offer process latitudes that are comparable to more costly alternatives such as two-exposure alternating PSM. To use DDL for printing actual IC devices, the original design data must be converted into a "vertical (V)" mask and a "horizontal (H)" mask for the respective X-dipole and Y-dipole exposures. We demonstrated that our model-based DDL mask data processing methodology is capable of converting complex 2D logic and memory designs into dipole-compatible mask layouts. [2,3] Due to the double exposure, stray light must be well controlled to ensure uniform printing across the entire chip. One intuitive solution to minimize stray light is to apply large patches of chrome in the open field areas in order to reduce the background (non-pattern area) exposure level. Unfortunately, this is not viable for a clear-field poly gate mask as it incorporates a positive photoresist process. We developed an innovative and practical background-shielding scheme called sub-resolution grating block (SGB), which is part of the DDL layout conversion method for full-chip application. This technique can effectively minimize the impact of long-range stray light on critical features during the two exposures. Reticles inspection is another important issue for the implementation of DDL technology. In this work, we reported a methodology on how to characterize defects and optimize inspection sensitivity for DDL RET reticles.
Membrane lipids in the pathogenesis of brain edema: phospholipids and arachidonic acid, the earliest membrane components changed at the onset of ischemia. (1980)

This chapter reviews studies concerning cellular membranes in the pathogenesis of cerebral edema. The main topics discussed are membrane lipids and the observation that the concentration of endogenous free fatty acids increases rapidly and reversibly in the brain after a single electroconvulsive shock. This change suggests that an active deacylation takes place. In addition, brief periods of ischemia trigger a strikingly high production of free fatty acids not from triacylglycerol breakdown but likely arising from membrane lipids. Since cellular membrane damage takes place during the early stages of edema either in neural or endothelial cells, the described changes may be involved in the pathogenesis of brain edema. The free fatty acid production is a unique property of the mature brains of rat, mouse, and monkey. It predominates in gray matter as compared to white matter. The rate of production during early ischemia is comparable to that observed in adipose tissue under maximal hormonal stimulation. In newborn mammalians, as in brains of mature poikilotherms, rates of production during early ischemia are low. The involvement of inositol lipids in the process is suggested since stearic and arachidonic acid are not only produced as free fatty acids but are also acylated in diacylglycerol during the first few minutes of rat and mouse brain ischemia. Prostaglandins and their metabolites of free arachidonic acid, at least during the first 4 to 5 min of ischemia when the rate of production is linear. Harmful membrane effects of lipid peroxides are also discussed.
Advances in LC characterization with application to development of mm-wave devices (2010)

In this paper the current state of research in our labs on the mm-wave characterization of LCs and the application of LC in development of two devices were presented. It has been shown that the characterization of LCs can be done using the resonant and broadband methods, but each has its own advantages and disadvantages. Also shown were a LC-based reflection type phase shifter, providing a large phase shift compared to the conventional transmission line phase shifters and a long LC-based resonator with multiple tunable resonant frequencies.