gebhart/patrepeval huggingface dataset:
Ventriculoarterial Matching in Exercising Dogs (2020)

90We investigated how changes in ventricular contractility and hemodynamics associated with exercise influence the mechanical energy transmission from the left ventricle to the arterial system. Using five chronically instrumented dogs preconditioned to run on a treadmill, we imposed exercise loads of various degrees by altering the speed and slope of the treadmill (up to 7 km/h and a 20% slope). We evaluated ventricular contractility by end-systolic elastance (Ees) and arterial properties in terms of the effective arterial elastance (Ea). Ea was estimated by the ratio of mean aortic pressure to stroke volume. With exercise, Ees increased from 7.4 to 11 mmHg/ml (p&lt;0.001) and Ea tended to increase from 5.2 to 7.1 mmHg/ml, while the ratio of Ea to Ees remained fairly constant (from 0.75 ± 0.24 to 0.65 ± 0.21, NS). The estimated ratio of stroke work (SW) to the maximal SW theoretically derived was 0.95 ± 0.06 at rest and was 0.93 ± 0.10 during exercise. Similarly, the ratio of SW to cardiac oxygen consumption estimated from the pressure-volume area was 0.97 ± 0.02 at rest and was 0.99 ± 0.01 during exercise of its theoretical maximal value. We concluded that external work of the left ventricle of dogs was adjusted to nearly maximal during exercise as well as at rest, without compromising the conversion efficiency of metabolic energy to SW. Needless to say, however, whether the maximization of external work is the optimization criterion of the cardiovascular regulation remains to be seen.
Microwave Irradiation Assists the Synthesis of a Novel Series of bis-Arm s-Triazine Oxy-Schiff Base and Oxybenzylidene Barbiturate Derivatives (2018)

A novel series of <i>s</i>-triazines incorporating 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde was prepared and fully characterized. The reaction was carried out via stepwise nucleophilic aromatic substitution of chlorine atoms in cyanuric chloride. The first chlorine was substituted by different amines (morpholine, piperidine, or diethylamine) to afford 2,4-dichloro-6-substituted-1,3,5-triazine. The second and third chlorines were substituted by benzaldehyde derivatives in the presence of Na₂CO₃ as a HCl scavenger to afford the target products: s-triazine oxyaldehyde derivatives (dipodal). The dipodal derivatives were reacted with acid hydrazide, hydralazine, barbituric, or thiobarbituric acid derivatives using conventional heating or microwave irradiation to afford the di-arm <i>s</i>-triazine oxy-Schiff base and oxybenzylidene barbiturate derivatives in good yields. Microwave irradiation done in less solvent afforded the target product in less reaction time with good yield and purity. These types of derivatives might have special interest in coordination and medicinal chemistry.
Wearable and Flexible Ozone Generating System for Treatment of Infected Dermal Wounds (2020)

Wound-associated infections are a significant and rising health concern throughout the world owing to aging population, prevalence of diabetes, and obesity. In addition, the rapid increase of life-threatening antibiotic resistant infections has resulted in challenging wound complications with limited choices of effective therapeutics. Recently, topical ozone therapy has shown to be a promising alternative approach for treatment of non-healing and infected wounds by providing strong antibacterial properties while stimulating the local tissue repair and regeneration. However, utilization of ozone as a treatment for infected wounds has been challenging thus far due to the need for large equipment usable only in contained, clinical settings. This work reports on the development of a portable topical ozone therapy system comprised of a flexible and disposable semipermeable dressing connected to a portable and reusable ozone-generating unit via a flexible tube. The dressing consists of a multilayered structure with gradient porosities to achieve uniform ozone distribution. The effective bactericidal properties of the ozone delivery platform were confirmed with two of the most commonly pathogenic bacteria found in wound infections, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus epidermidis</i>. Furthermore, cytotoxicity tests with human fibroblasts cells indicated no adverse effects on human cells.
Luminescence of Novel Neodymium Sulfonylaminate Complexes in Organic Media (2000)

Eine stabile NdIII-Lumineszenz in einem organischen Lösungsmittel, dessen Moleküle C-H-Bindungen enthalten, wurde erstmals durch Komplexierung von NdIII mit langkettigen perfluoralkylierten Liganden wie Bis(perfluoroctylsulfonyl)aminat (pos) erreicht. Der Komplex [Nd(pos)3] hat eine Emissions-Quantenausbeute von 3.0±0.5 % in nichtdeuteriertem Aceton. Die sperrigen pos-Liganden unterdrücken die Anregung von C-H-Schwingungen, die Energieübertragung bei diffusionsvermittelten Kollisionen sowie die Koordination von Acetonmolekülen (siehe Bild) an das NdIII-Zentrum, was sonst zu einer Lumineszenzlöschung führen würden.
Macromol. Rapid Commun. 16/2012 (2012)

Back Cover: Precursor poly(p-phenylene vinylene) polymers eliminate pentanol at elevated temperatures providing ‘on-demand’ vapor-phase lubrication for MicroElectroMechanical Systems. Further details can be found in the article by R. S. Johnson, C. M. Washburn, A. W. Staton, M. W. Moorman, R. P. Manginell, M. T. Dugger, and S. M. Dirk* on page 1346.
Development of a Luminescent Bioassay for Thyroid Stimulating Antibodies (1999)

The hyperthyroidism of Graves Disease (GD) is due to thyroid stimulating antibodies (TSAb) which are thyrotropin (TSH) agonists. They are detected routinely by measuring their ability to inhibit TSH binding to the receptor (TBII), which does not reflect their true biological activity. Current bioassays which measure cAMP by RIA, are not suitable for routine use. We have developed a luminescent bioassay for TSAb, by introducing a cAMP responsive luciferase construct into CHO cells stably expressing the human TSH receptor (TSHR). Clone lulul displays dose dependent TSH response detectable from 10 microU/ml and maximal at 10 mU/ml when a >25 fold increase in light output is obtained. 34 euthyroid sera were tested to determine a reference range, with values >1.5 relative light units (R.L.U.) being considered positive. An international TSAb standard responded in a dose dependent manner with 10 mIU/ml giving an R.L.U. of >10. The assay was adapted to a 96 well format for automatic readout and 100 treated GD samples (50 TBII negative and 50 TBII positive) were tested, 73% being positive. In contrast only 4% of 79 control sera from individuals with Hashimoto's, non-thyroid autoimmunity or multinodular goitre produced R.L.U. >1.5. When 44 of the GD sera were compared in a traditional salt-free bioassay, 61% were positive compared with 75% in the new luminescent assay. In conclusion, we have developed a luminescent bioassay for TSAb, using unfractionated serum which is capable of high throughput suitable for routine use.
Formation of Cagelike Intermediates from Nonrandom Cyclization during Acid-Catalyzed Sol-Gel Polymerization of Tetraethyl Orthosilicate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of Cagelike Intermediates from Nonrandom Cyclization during Acid-Catalyzed Sol-Gel Polymerization of Tetraethyl OrthosilicateLi Voon Ng, Penny Thompson, Jorge Sanchez, Christopher W. Macosko, and Alon V. McCormickCite this: Macromolecules 1995, 28, 19, 6471–6476Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00123a012https://doi.org/10.1021/ma00123a012research-articleACS PublicationsRequest reuse permissionsArticle Views571Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex (2015)

Peroxisome-proliferator activated receptor-γ (PPARγ) is a nuclear hormone receptor that forms a heterodimeric complex with retinoid X receptor-α (RXRα) to regulate transcription of genes involved in fatty acid storage and glucose metabolism. PPARγ is a target for pharmaceutical intervention in type 2 diabetes, and insight into interactions between PPARγ, RXRα, and DNA is of interest in understanding the function and regulation of this complex. Phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) has been shown to dysregulate the expression of metabolic regulation genes, an effect that is counteracted by PPARγ ligands. We applied molecular dynamics (MD) simulations to study the relationship between the ligand-binding domains of PPARγ and RXRα with their respective DNA-binding domains. Our results reveal that phosphorylation alters collective motions within the PPARγ-RXRα complex that affect the LBD-LBD dimerization interface and the AF-2 coactivator binding region of PPARγ.
Crystallographer's Challenge in the 21st Century. 3. Frontier of Protein Crystallography. Structural Genomics. (2001)

Structural genomics is expected to supply a large number (tens of thousands) of protein structures in a high through-put manner. These structural data will accelerate scientific discovery in all fields of biological science, including human health and disease. The oldest structural genomics projects of the RIKEN Structural Genomics Initiative has two major goals: to determine mammalian, plant, and bacterial protein structures by X-ray crystallogra-phy and NMR spectroscopy and to perform functional analyses with the target proteins. The prediction of the polypeptide backbone conformation will be possible within several years.
Secure Implementing a Virtual Network on the SDN Data Plane (2021)

The paper continues the investigations on the implementation of virtual networks on the SDN data plane which is modeled by a graph of physical connections between network nodes. A virtual network is defined as a set of ordered host pairs (sender, receiver), and it is implemented by a set of host-host paths that uniquely determine the switch settings. The opportunities to transmit a packet are limited by the host weights (priorities): a packet can be only transmitted from a host to a host if the sender has at most the same priority as the recipient, and thus, a set of paths is permissible if its every subset connects permissible host pairs. In the paper, it is proven that differently from the case when every host pair is permissible, in the graph with priorities a permissible path implementation does not exist for every set of permissible hosts. Moreover, it is shown that is some cases when such an implementation exists, the implementation is not possible without paths with cycles where packets can move infinite and without duplicate paths when a host can get the same packet several times. Using the notion of a perfect set of paths a criterion is established when every permissible set of hosts can be safely implemented by a set of paths without cycles but possibly with duplicate paths.
Two-Dimensional Environment Recognition by Audible Sound with Weighted Likelihood Function and Standing Wave (2021)

In recent years, many kinds of sensors have been studied to recognize the environment, and they are used for AR and VR applications and for SLAM. Although ultrasonic signals with high directivity and high resolution are often used, there are problems such as ultrasonic exposure and grating noise at the rising edge. In this paper, we propose a new active sensing method based on audible sounds that is robust to environmental noise by combining weighting likelihood functions and standing waves. Compared to ultrasonic signals, audible sound tends to spread out, which leads to misalignment of distance estimates and loss of map consistency over time. Therefore, we derive the effective azimuth angle based on the directional characteristics of the speaker and calculate the likelihood of the presence or absence of obstacles using the observation model. In addition, we introduce occupancy grid mapping to produce a map that best explains the estimated distances. We performed real-world two-dimensional environment recognition experiments using the proposed method to detect and map surrounding obstacles, and showed the effectiveness of the method.
Mycolic acids for the control of tuberculosis (2007)

Mycobacterium tuberculosis, the causative agent of tuberculosis, is on the rise again in step with the HIV/AIDS pandemic. Characteristically, M. tuberculosis features a hydrophobic cell envelope conferring resistance to degradation by host defences and impeding drug entry. This review focuses on mycolic acids, the distinctive cornerstone lipids of that cell envelope. The structure of these α-alkyl-β-hydroxy fatty acids is discussed along with their relation to pathogenicity. From the uniqueness of their structures and biosynthesis, rationales to target enzyme complexes involved in mycolic acid biosynthesis are discussed. The uniqueness of mycolic acids is also the basis of their application for immunodiagnosis of tuberculosis, an application showing renewed promise. Finally, emerging insights into the role of mycolic acids in the host–pathogen interaction are discussed, ascribing to mycolic acids a function in promoting cellular immune defences but also immune tolerance and the formation of foam macrophages.
Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study (2023)

Women who experience APO have earlier onset of cerebrovascular disease, with the earliest onset in those with more than 1 affected pregnancy.
RELATION BETWEEN ELECTRICAL CONDUCTIVITY AND THERMAL DESORPTION SPECTRA FOR COBALT PHTHALOCYANINE-OXIDATIVE GAS SYSTEM (1980)

Abstract In the thermal desorption spectra of β-CoPc–NO2 system two peaks appeared. The first and second peaks were assigned to the desorption of the NO2 on the pseudoaromatic rings and on the Co ions, respectively. The electrical conductance was enhanced mainly by the interaction of the pseudoaromatic ring with NO2.
Non-steroidal progesterone receptor modulators (2003)

Progesterone (P4) plays an essential role in female reproduction and progesterone receptor (PR) agonists have been used in female contraceptives and in postmenopausal hormone therapy. Recent studies in women and non-human primates show that PR antagonists may also have potential as contraceptive agents and for the treatment of various gynaecological and obstetric diseases, including fibroids, endometriosis and, possibly, hormone-dependent cancers. Clinically available PR agonists and antagonists are steroidal compounds and often cause various side effects due to their functional interaction with other steroid receptors. Recently, numerous receptor-selective non-steroidal PR agonists and antagonists have emerged. This patent review will focus on the latest developments in these areas (since 2000).
Prognosis of Breast Cancer with Small Primary Tumor (Pt1) (1991)

Prognosis of 141 women with pT1 breast cancer from a defined urban area was investigated. Only one of the 47 women with a primary tumor diameter less than or equal to 10 mm in diameter (pT1a or pT1b) died from breast cancer within 5 years after the diagnosis. The 5-year survival rate corrected for intercurrent deaths of the women with pT1c cancer (from 11 to 20 mm in diameter, n = 94) was 83%; 96% in pT1cN0 and 62% in pT1cN+ cancer respectively (p less than 0.0001). In a multivariate analysis axillary nodal status and S-phase fraction determined by flow cytometry were independent prognostic factors. The excellent survival of women with pT1a or pT1b breast cancer, and women with pT1cN0 breast cancer with no axillary nodal metastases, does not support the policy of giving adjuvant treatment to all women with breast cancer.
Novel cost-effective approach to produce nano-sized contact openings in an aluminum oxide passivation layer up to 30 nm thick for CIGS solar cells (2021)

Abstract This work presents a novel method of local contact openings formation in an aluminum oxide (Al 2 O 3 ) rear surface passivation layer by the selenization of the lithium fluoride (LiF) salt on top of the Al 2 O 3 for ultra-thin copper indium gallium (di)selenide (CIGS) solar cells (SCs). This study introduces the potentially cost-effective, fast, industrially viable, and environmentally friendly way to create the nano-sized contact openings with the homogeneous distribution in the thick, i.e. up to 30 nm, Al 2 O 3 passivation layer. The passivation layer is deposited by atomic layer deposition, while the LiF layer is spin-coated. Selenization is done in the H 2 Se atmosphere and the optimal process parameters are deduced to obtain nano-sized and uniformly allocated openings as confirmed by scanning electron microscopy images. The contact openings were produced in the different thicknesses of the alumina layer from 6 nm to 30 nm. Furthermore, the Al 2 O 3 rear surface passivation layer with the contact openings was implemented into ultra-thin CIGS SC design, and one trial set was produced. We demonstrated that the created openings facilitate the effective current collection through the dielectric Al 2 O 3 layer up to 30 nm thick. However, the upper limit of Al 2 O 3 thickness in which the contact openings can be created by the described method is not established yet. The produced passivated CIGS SCs show increased external quantum efficiency response due to the optical enhancement of the passivated cells. However, the production of SCs on the Al 2 O 3 passivation layer with the openings created by selenization of LiF is not optimized yet.
Loss Network Models and Multiple Metric Performance Sensitivity Analysis for Mobile Wireless Multi-hop Networks (2008)

We develop and evaluate a new method for estimating and optimizing various performance metrics of mobile wireless multi-hop networks, including MANETs. The method utilizes approximate (throughput) loss model that couples the physical, MAC and routing layers effects. The model provides quantitative s
High-Temperature Stability and Enhanced Performance of a-Si:H TFT on Flexible Substrate Due to Improved Interface Quality (2010)

We have investigated the effect of anneal time on the performance and temperature-dependent stability of low-temperature-fabricated (180°C) hydrogenated amorphous silicon (a-Si:H) thin-film transistors (TFTs) on flexible substrates. For TFTs annealed for 48 h, the subthreshold slope and off-current were reduced by a factor of ~3 and by two orders of magnitude, respectively, when compared to unannealed TFTs. Furthermore, longer annealed TFTs showed a significant improvement in their stability when compared to unannealed TFTs. The lifetime values for the 48- and 96-h-annealed TFTs improved by a factor of ~3 compared to unannealed TFTs when the threshold voltage shift is extrapolated to 10 V. Stability at high temperatures with better lifetimes for the longer annealed TFTs is due to improvement in the a-Si:H/SiN <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</i> interface quality by the reduction of trapped charges inside the insulator. For all the TFTs at a positive gate bias, ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> follows a power law dependence with time, indicating state creation. A low β value (0.6 for unannealed TFTs to 0.37 for 96-h-annealed TFTs) indicates a good-quality a-Si:H channel and/or the a-Si:H/insulator interface after longer anneals.
On the capacity of the reachback channel in wireless sensor networks (2004)

We consider the problem of reachback communication in wireless sensor networks: multiple sensors are deployed on a field, and they collect local measurements of some random process which then need to be encoded and reproduced at a remote location. In this paper we present a number of information theoretic bounds on the performance of a distributed transmission array that is formed by a large number of cheap, unreliable sensors. We formulate this problem in terms of classical network information theory concepts, formulation which leads us to consider two important cases: transmission of correlated sources over multiple independent channels, and rate/distortion with separate encoders.
Investigation of the polar electrojet-current system using radio-wave heating from a ground-based facility (1990)

The High Power Auroral Stimulation (HIPAS) heating facility has been used to modulate D region ionospheric currents at high latitudes, producing very low frequency (VLF) radio wave emissions. The behavior of these ionospheric currents can be deduced from a comprehensive study of the VLF signals received at a local field site. This Paper examines the relationship between the VLF magnetic field strength measured on the ground and the intensity of an overhead electrojet current for the purpose of enhancing communications. The mapping of the polar electrojet current from the E region down through the D region, where it can then be modulated by the heater beam, is investigated. A finite difference solution to the electrojet mapping .problem is presented in which arbitrary conductivity profiles can be specified. Results have been obtained using a simple Cowling model of the electrojet. These results indicate that for electrojets flowing between 100 and 110 km with scale sizes in excess of 100 km, the mapping of the horizontal current density can be completely characterized in terms of the Pedersen and Hall conductivities. This indicates that the mapping becomes independent of scale sizes which exceed 100 km. A promising new diagnostic technique, for studying ionosphericmore » D region currents, has been implemented using the HIPAS facility. This technique involves high frequency (HF) beam steering for localized VLF generation in the mapped region below electrojets. Beam steering has been used to estimate the strength and current distribution of the polar electrojet, and for charting the movements of overhead currents.« less
Search for contact interactions and large extra dimensions in the dilepton mass spectra from proton-proton collisions at $$ \sqrt{s}=13 $$ TeV (2019)

A bstract A search for nonresonant excesses in the invariant mass spectra of electron and muon pairs is presented. The analysis is based on data from proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment in 2016, corresponding to a total integrated luminosity of 36 fb −1 . No significant deviation from the standard model is observed. Limits are set at 95% confidence level on energy scales for two general classes of nonresonant models. For a class of fermion contact interaction models, lower limits ranging from 20 to 32 TeV are set on the characteristic compositeness scale Λ. For the Arkani-Hamed, Dimopoulos, and Dvali model of large extra dimensions, the first results in the dilepton final state at 13 TeV are reported, and values of the ultraviolet cutoff parameter Λ T below 6.9 TeV are excluded. A combination with recent CMS diphoton results improves this exclusion to Λ T below 7.7 TeV, providing the most sensitive limits to date in nonhadronic final states.