gebhart/patrepeval huggingface dataset:
Cover Feature: Self‐Assembly and Aggregation‐Induced Emission in Aqueous Media of Responsive Luminescent Copper(I) Coordination Polymer Nanoparticles (Chem. Eur. J. 32/2021) (2021)

The formation of coordination polymer nanoparticles by a copper(I) coordination compound containing cubane-like clusters as nodes connected by hybrid thioether-phosphine ligands has been achieved in aqueous media. The formed particles display a yellow aggregation-induced emission. The change in the environment triggers a morphological transformation towards elongated aggregates due to changes in the coordination environment, opening the cubane units and causing a cyan emission. More information can be found in the Full Paper by G. Moreno-Alcántar et al. (DOI: 10.1002/chem.202100865).
Modeling of Floating-Body Devices Based on Complete Potential Description (2008)

Advanced MOSFETs exploit the carrier confinement to suppress the short-channel effect, which is realized by reducing the bulk layer thickness. The ongoing developments of the multi-gate MOSFET as well as the fully-depleted SOI-MOSFET with ultra thin silicon layer are proved to be applicable beyond the 50nm technology node. However, these advanced devices suffer from the floating-body effect caused by an unfixed body node, which plays an important role for the device performances. Here we present a modeling approach, based on a consistent potential description, for simplifying and solving the Poisson equation with a floating-body node.
StreamHover: Livestream Transcript Summarization and Annotation (2021)

Sangwoo Cho, Franck Dernoncourt, Tim Ganter, Trung Bui, Nedim Lipka, Walter Chang, Hailin Jin, Jonathan Brandt, Hassan Foroosh, Fei Liu. Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing. 2021.
Inverse designed metalenses with extended depth of focus (2020)

We design, fabricate and characterize a cylindrical metasurface lens operating at — 625nm with a depth of focus exceeding that of an ordinary lens using adjoint optimization-based inverse electromagnetic design.
A 2-terminal perovskite/silicon multijunction solar cell enabled by a silicon tunnel junction (2015)

With the advent of efficient high-bandgap metal-halide perovskite photovoltaics, an opportunity exists to make perovskite/silicon tandem solar cells. We fabricate a monolithic tandem by developing a silicon-based interband tunnel junction that facilitates majority-carrier charge recombination between the perovskite and silicon sub-cells. We demonstrate a 1 cm2 2-terminal monolithic perovskite/silicon multijunction solar cell with a VOC as high as 1.65 V. We achieve a stable 13.7% power conversion efficiency with the perovskite as the current-limiting sub-cell, and identify key challenges for this device architecture to reach efficiencies over 25%.
Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells (2015)

At the cellular level, zyxin is a key regulator of stretch-induced gene expression. Loss of zyxin drives VSMCs toward a synthetic phenotype, a process further consolidated by exaggerated stretch.
Effect of Coating on Mechanical Properties of Magnesium Alloy Friction Stir Spot Welds (2011)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussion Conclusions Acknowledgements
Direct Fabrication of Photonic Crystal on Glass Substrate by Nanoimprint Lithography (2006)

We have successfully fabricated a two-dimensional photonic crystal with a 300 nm period on a glass substrate by direct nanoimprint lithography. A uniform photonic crystal with an area of 3 ×3 mm2 was obtained at the relatively low temperature of 360°C. Our results can be applied to make various photonic-nanostructure devices.
ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death (2017)

ADAMs (a disintegrin and metalloproteinases) are involved in various biological events such as cell adhesion, migration and invasion, membrane protein shedding and proteolysis. However, there have been no systematic studies on the expression of ADAMs in human ovarian carcinomas. We therefore examined mRNA expression of all the proteolytic ADAM species including ADAM8, 9, 10, 12, 15, 17, 19, 20, 21, 28, 30, 33 and ADAMDEC1 in human ovarian carcinomas, and found that prototype membrane-anchored ADAM9m, but not secreted isoform ADAM9s, is significantly over-expressed in carcinomas than in control non-neoplastic ovarian tissue. Among the histological subtypes of serous, endometrioid, mucinous and clear cell carcinomas, ADAM9m expression was highest in clear cell carcinomas. Immunohistochemistry showed that all the clear cell carcinoma samples displayed ADAM9m primarily on the carcinoma cell membrane. By immunoblotting, ADAM9m was detected mainly in an active form in the clear cell carcinoma tissues. When two clear cell carcinoma cell lines (RMG-I and TOV21G cells) with ADAM9m expression were treated with cisplatin, viability was significantly reduced and apoptosis increased in ADAM9m knockdown cells compared with mock transfectants. In addition, treatment of the cells with neutralizing anti-ADAM9m antibody significantly decreased viability compared with non-immune IgG, whereas ADAM9m over-expression significantly increased viability compared with mock transfectants. Our data show, to the best of our knowledge, for the first time, that ADAM9m is over-expressed in an activated form in human ovarian clear cell carcinomas, and suggest that ADAM9m plays a key role in cisplatin resistance.
Syngeneic Donor Hematopoietic Stem Cell Transplantation Is Associated with High Rates of Engraftment Syndrome (2010)

Engraftment syndrome (ES), typically characterized by noninfectious fever, rash, and/or noncardiogenic pulmonary edema, is a complication of autologous and allogeneic hematopoietic stem cell transplantation (HSCT). There are no data on ES after syngeneic HSCT. We retrospectively analyzed syngeneic HSCT outcomes and determined ES incidence, risk factors, and prognostic impact. Thirty-two adult patients with a median age of 46 years (range: 22-60) underwent syngeneic HSCT at our institution between July 1986 and April 2009, primarily for hematologic malignancies (65% lymphoid-including 15% plasma cell; 31% myeloid). The median duration of follow-up was 6.1 years (range: 3.7 months to 18.1 years). Five-year progression-free and overall survival (PFS, OS) was 52% and 67%, respectively. Five-year overall cumulative incidence of relapse and nonrelapse mortality (NRM) was 37.6% and 10.2%, respectively; with increased relapse incidence of 76.3% in myeloid disease (P = .002). Fifteen patients (47%) met diagnostic criteria for ES, 10 (67%) of whom received systemic steroids. Five-year PFS was 47% in patients with ES versus 56% in those without (P = .37). Five-year OS was 63% with ES versus 71% without (P = .80). Five-year cumulative incidence of NRM was 21% with ES versus 0% without (P = .06). Five-year cumulative incidence of relapse was 32% with ES and 44% without (P = .68). Older age (P = .05) and possibly total body irradiation-based conditioning (P = .09) were risk factors for developing ES. In multivariable Cox models only diagnosis (myeloid disease) impaired OS and PFS. In summary, we document a high incidence of ES after syngeneic HSCT. The trend of increased NRM after ES requires reevaluation in a larger syngeneic HSCT cohort.
Immunological changes following intraperitoneal administration of a formulated IL-12 plasmid in combination with standard neoadjuvant chemotherapy in patients with newly diagnosed advanced stage ovarian cancer. (2017)

156 Background: The translational component of a Phase I study of weekly intraperitoneal GEN-1, an IL-12 plasmid formulated with polyethyleneglycol-polyethyleneimine cholesterol lipopolymer, in combination with dose-dense weekly taxane (T) and carboplatinum (C) every 3 weeks in newly diagnosed epithelial ovarian, fallopian tube, or primary peritoneal cancer (EOC) patients undergoing neoadjuvant therapy (NAC). Our hypothesis is that the GEN-1 plus NAC treatment will reprogram the tumor immune microenvironment towards a potent antitumor immune response. Methods: Patients received GEN-1 at escalating dose levels from 36 mg/m 2 , 47 mg/m 2 , 61 mg/m 2 , to 79 mg/m 2 weekly for 8 treatments with concurrent T/C. Tumor samples collected at time of diagnostic laparoscopy and interval debulking (IDB). Blood and peritoneal ascites were collected before and after treatment. The immunological analysis included frequency of immune cell populations and cytokine levels in tumor, blood, and peritoneal ascites and cell-specific mRNA expression profile. Results: The preliminary results obtained from first two cohorts show that GEN-1 may be enhancing post-treatment changes in immune cell populations including an increase in cytotoxic CD8+ T-cells and decrease in immunosuppressive FoxP3+ T-reg cells in tumor at IDB. The CD8:Foxp3 ratio appeared to be skewing beneficially towards more cytotoxic T lymphocyte and away from suppressive cells in most patients. The analysis of circulating immune cells 21 days after first GEN-1 treatment showed a decrease in circulating CD123+ plasmacytoid dendritic cells, but no change in CD11c+ myeloid dendritic cells. There were no major changes in the frequency of circulating T-cells. Additional analyses from this study are in progress. Conclusions: Based on preliminary analyses of cohorts 1 &amp; 2 samples analyzed, the treatment of EOC patients with GEN-1 and NAC has resulted in favorable immunological responses. Updated results to be presented at meeting. Clinical trial information: NCT02480374.
Nuclear receptor gene alteration in human induced pluripotent stem cells with hepatic differentiation propensity (2014)

These findings will be useful for not only elucidating mechanisms of hepatic differentiation of hiPS cells but also cell-based therapy for liver diseases.
A Novel Sensitive Immunoassay Targeting the 5-Methylthio- d -Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis (2018)

The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated the potential of 100 novel monoclonal antibody pairs targeting a variety of LAM epitopes on a sensitive electrochemiluminescence platform to improve the diagnostic accuracy. In the screening, many antibody pairs showed high reactivity to purified LAM but performed poorly at detecting urinary LAM in clinical samples, suggesting differences in antigen structure and immunoreactivity of the different LAM sources. The 12 best antibody pairs from the screening were tested in a retrospective case-control study with urine samples from 75 adults with presumptive TB. The best antibody pair reached femtomolar analytical sensitivity for LAM detection and an overall clinical sensitivity of 93% (confidence interval [CI], 80% to 97%) and specificity of 97% (CI, 85% to 100%). Importantly, in HIV-negative subjects positive for TB by sputum smear microscopy, the test achieved a sensitivity of 80% (CI, 55% to 93%). This compares to an overall sensitivity of 33% (CI, 20% to 48%) of the Alere LF-LAM and a sensitivity of 13% (CI, 4% to 38%) in HIV-negative subjects in the same sample set. The capture antibody targets a unique 5-methylthio-d-xylofuranose (MTX)-dependent epitope in LAM that is specific to the <i>Mycobacterium tuberculosis</i> complex and shows no cross-reactivity with fast-growing mycobacteria or other bacteria. The present study provides evidence that improved assay methods and reagents lead to increased diagnostic accuracy. The results of this work have informed the development of a sensitive and specific novel LAM point-of-care assay with the aim to meet the WHO's performance target for TB diagnosis.
THE EFFECT OF THIAMINE DEFICIENCY ON THE ACETYLCOENZYMEA AND ACETYLCHOLINE LEVELS IN THE RAT BRAIN (1973)

Abstract— It is shown that transketolase activities in red blood cells and whole brain of normal and thiamine‐deficient rats correlate well with heart frequencies. The effect of thiamine depletion on the levels of acetylcoenzyme A (acetyl‐CoA) and acetylcholine (ACh), and on the activities of pyruvate dehydrogenase, choline acetyl‐transferase and acetylcholine esterase was studied in whole brains of thiamine‐deficient, thiamine‐supplemented ad libitum and pair‐fed rats. The concentrations of acetyl‐CoA and ACh decreased in thiamine‐deficient brains by 42 and 35 per cent, respectively. Total pyruvate dehydrogenase activity did not change during vitamin B 1 deficiency. The ‘resolved’ enzyme, reconstituted with thiamine diphosphate, had an association constant of 5.4 × 10 −6 m . Choline acetyltransferase and acetylcholine esterase activities remained unchanged in thiamine deficiency. Possible mechanisms which could explain the reduced Ach levels in vitamin B 1 deficiency are discussed.
Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks (2008)

We investigated inflammation in rats performing a low repetition, negligible force (LRNF) or high repetition, negligible force (HRNF) task of reaching and retrieving food pellets at target rates of two or four reaches/min for 2 h/day, for 6-8 weeks. Serum was assayed for 11 cytokines and chemokines; forelimb tissues for four cytokines. Macrophages were counted in forelimb tissues of LRNF rats to add to results from our previous studies of HRNF rats. In HRNF rats, serum IL-1 alpha, IL-1 beta, TNFalpha, MIP2, MIP3a, and RANTES were elevated in weeks 6 and 8. In contrast, only MIP2 and MIP3a increased in serum of LRNF rats. In 8 week HRNF reach limb tissues, IL-1 alpha, IL-1beta, TNFalpha, and IL-10 increased in distal bones, IL-1 alpha and -beta in muscles, and TNFalpha in tendons. Only IL-10 increased in LRNF reach limb muscles in week 8. Serum IL-1 alpha and MIP2 correlated with macrophages in LRNF loose connective tissues, serum MIP3a and MIP2 correlated negatively with grip strength, while serum TNFalpha, MIP3a, and MIP2 correlated positively with total number of reaches. Thus, several tissue and circulating cytokines/chemokines increase in an exposure dependent manner following short-term performance of repetitive reaching tasks and correlate with macrophage infiltration and decreasing grip strength.
Weighting function effects in a direct regularization method for image-guided near-infrared spectral tomography of breast cancer (2018)

Structural image-guided near-infrared spectral tomography (NIRST) has been developed as a way to use diffuse NIR spectroscopy within the context of image-guided quantification of tissue spectral features. A direct regularization imaging (DRI) method for NIRST has the value of not requiring any image segmentation. Here, we present a comprehensive investigational study to analyze the impact of the weighting function implied when weighting the recovery of optical coefficients in DRI based NIRST. This was done using simulations, phantom and clinical patient exam data. Simulations where the true object is known indicate that changes to this weighting function can vary the contrast by 10%, the contrast to noise ratio by 20% and the full width half maximum (FWHM) by 30%. The results from phantoms and human images show that a linear inverse distance weighting function appears optimal, and that incorporation of this function can generally improve the recovered total hemoglobin contrast of the tumor to the normal surrounding tissue by more than 15% in human cases.
A Multiple Attribute User-Centric Backhaul Provisioning Scheme Using Distributed SON (2016)

The backhaul network is a critical challenge towards the success of 5G and corresponding difficulties are many-fold, such as network coverage expansion, very high bandwidth, ultra- low latency and energy consumption, at a minimum cost. No single backhaul solution can address all these requirements but, on the other hand, not all of the backhaul links require the same set of stringent requirements. To this end, we propose a novel scheme that capitalises on the diversity in both performance requirements and backhaul capabilities to maximise the system-centric as well as user-centric performance indicators. The user-centric backhaul provisioning scheme uses multiple attribute decision making (MADM) for the user-cell-backhaul association criteria in a way that intelligently associates users with available cells based on corresponding dynamic radio and backhaul conditions while abiding by users' requirements. Radio cells broadcast multiple bias factors, each reflecting a dynamic performance indicator of the end-to-end network performance such as capacity, latency, resilience, energy consumption, etc. A given user would employ these factors to derive a user-centric cell ranking that motivates it to select the cell with radio and backhaul capabilities that conform to the user requirements. Reinforcement learning is used by the radio cell to optimise the bias factors for each performance indicator in a way that maximises the system performance and users' end-to-end quality of experience (QoE). Preliminary results based on a case study show considerable improvement in users QoE when compared to state-of-the-art user-cell association schemes.
Supplementary Table S3 from Gene Signatures for the Prediction of Response to Bacillus Calmette-Guérin Immunotherapy in Primary pT1 Bladder Cancers (2023)

Supplementary Table S3 from Gene Signatures for the Prediction of Response to Bacillus Calmette-Guérin Immunotherapy in Primary pT1 Bladder Cancers
Use of room-temperature bias sputtering to decrease intergranular coupling in magnetic media deposited on polymeric substrates (2003)

CoCrPt thin films sputter-deposited on polymeric substrates without explicit heating were investigated as a function of substrate bias. The coercivity and the coercive squareness in the CoCrPt films were strongly dependent on bias voltage. A significant reduction in the coercive squareness S/sup */ from a value near unity was observed with increasing bias voltage, implying a decrease in the degree of intergranular exchange coupling. With the addition of explicit substrate heating, S/sup */ was further reduced, and was associated with a significant improvement of coercivity. This paper presents a possible approach to achieve media with acceptably low exchange coupling deposited at temperatures well below the glass transition temperature of polymeric substrates.
Single-VCSEL 100-Gb/s Short-Reach System Using Discrete Multi-Tone Modulation and Direct Detection (2015)

We demonstrate an up to 115-Gb/s line-rate short-reach system using a single 1550-nm VCSEL with discrete multi-tone modulation and direct detection, which can cover 500-m to 4-km standard-single-mode fiber at 95-Gb/s to 105-Gb/s bit rates.
The STE-20 kinase TAOK3 regulates obesity-associated metabolism and type 2 immunity in murine adipose tissue (2021)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Representational frames in video annotation (2002)

One of the tenets of machine vision is that choice of representation is critical in describing a scene; representations are selected that make important information explicit and that allow domain constraints to be brought to bear. In dynamic scene annotation, there may be no single representation appropriate for analysis, as the imagery is dynamic and choice of best representation may vary over time. The authors present two examples of where the selection of representational frame-the coordinate system in which the representation describes the scene-is determined by the dynamics of the scene.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Neuronal Cell-type Engineering by Transcriptional Activation (2021)

Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed screening for inducing neuronal differentiation using CRISPR-Cas transcriptional activation (CRISPRa) and open reading frame (ORF) expression. Critical technical parameters of CRISPRa and ORF-based strategies for neuronal programming are presented and discussed. In addition, recent progress on <i>in vivo</i> applications of CRISPRa to the nervous system are highlighted. Overall, CRISPRa represents a valuable addition to the experimental toolbox for neuronal cell-type programming.
Crystallization of hollow mesoporous silica nanoparticles (2014)

Complex 3D macrostructured nanoparticles are transformed from amorphous silica into pure polycrystalline α-quartz using catalytic quantities of alkaline earth metals as devitrifying agent. Walls as thin as 10 nm could be crystallized without losing the architecture of the particles. The roles of cation size and the mol% of the incorporated devitrifying agent in crystallization behavior are studied, with Mg(2+), Ca(2+), Sr(2+) and Ba(2+) all producing pure α-quartz under certain conditions.
Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data‐dependent acquisition (2008)

Tea is rich in polyphenols and has a variety of biological activities. In order to better understand the biological effects of tea constituents on human health, markers for their exposure and their metabolic fates are needed. Previously, we have characterized several catechin metabolites in the blood and urine, but more information on the metabolite profile of tea polyphenols is needed. In the present study, the human urinary metabolite profile of tea polyphenols was investigated using liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. With data-dependent MS/MS analysis by collecting the MS2 and MS3 spectra of the most intense ions in the sample, we identified more than twenty metabolites of tea polyphenols from human urine samples. (-)-Epigallocatechin (EGC) glucuronide, methylated EGC glucuronide, methylated EGC sulfate, (-)-epicatechin (EC) glucruronide, EC sulfate, methylated EC sulfate, as well as the glucuronide and sulfate metabolites of the ring-fission metabolites of tea catechins, 5-(3',4',5'-trihydroxyphenyl)-gamma-valerolactone (M4), 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone (M6) and 5-(3',5'-dihydroxyphenyl)-gamma-valerolactone (M6'), were the major human urinary metabolites of tea polyphenols. To our knowledge, this is the first report of the direct simultaneous analysis of the human urinary metabolite profile of tea polyphenols using single sample analysis. This method can also be used for thorough investigations of the metabolite profiles of many other dietary constituents.