gebhart/patrepeval huggingface dataset:
Iminodiacetic Acid (IDA) Cation-Exchange Nonwoven Membranes for Efficient Capture of Antibodies and Antibody Fragments (2021)

There is strong need to reduce the manufacturing costs and increase the downstream purification efficiency of high-value therapeutic monoclonal antibodies (mAbs). This paper explores the performance of a weak cation-exchange membrane based on the coupling of IDA to poly(butylene terephthalate) (PBT) nonwoven fabrics. Uniform and conformal layers of poly(glycidyl methacrylate) (GMA) were first grafted to the surface of the nonwovens. Then IDA was coupled to the polyGMA layers under optimized conditions, resulting in membranes with very high permeability and binding capacity. This resulted in IgG dynamic binding capacities at very short residence times (0.1-2.0 min) that are much higher than those achieved by the best cation-exchange resins. Similar results were obtained in the purification of a single-chain (scFv) antibody fragment. As is customary with membrane systems, the dynamic binding capacities did not change significantly over a wide range of residence times. Finally, the excellent separation efficiency and potential reusability of the membrane were confirmed by five consecutive cycles of mAb capture from its cell culture harvest. The present work provides significant evidence that this weak cation-exchange nonwoven fabric platform might be a suitable alternative to packed resin chromatography for low-cost, higher productivity manufacturing of therapeutic mAbs and antibody fragments.
ChemInform Abstract: Nickel‐Based Layered Superconductor, LaNiOAs. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A robust micro conveyer realized by arrayed polyimide joint actuators (1999)

A new micro motion system (micro-conveyer) based on arrays of movable robust silicon legs has been developed and investigated. The motion is achieved by thermal actuation of polyimide joint actuators using electrical heating. Successful experiments on moving flat objects in the millimeter range with high load capacity have been performed. The conveyer consists of a 15/spl times/5 mm/sup 2/ chip with 12 silicon legs each 500 /spl mu/m long. The maximum load conveyed on the structure was 2000 mg. Conveyance velocities up to 12 mm/s have been measured. Accelerated lifetime measurements demonstrate the long-term stability of the actuators. The function of the polyimide joint actuators is unaffected after more than 2/spl times/10/sup 8/ load cycles.
Study on Stiffness of Timing Belt for Servo Drive Systems (2003)

Because of low cost and accurate transfer characteristic, timing belt drives are widely used in servo systems such as industrial robots and office automation equipments. ln the servo systems, high performances are required for high productivity and quality of goods. High stiffness of drive system is expected in timing belt drives. We propose a method to estimate the torsional stiffness of the belt drive by using tensile experimental results. First, the torsoinal stiffness is analytically derived from shaft load and tensile stiffness when the driving and driven pulleys have the same radii. Next, in the case of different radii (reduction system), the relation between the shaft load and the torsional stiffness is analyzed by the same approach. Finally, tensile and torsional experiments are carried out. lt is confirmed that the analized results are in good agreement with the experimental results.
Immunoregulatory activity of the T-cell receptor alpha chain demonstrated by retroviral gene transfer. (1991)

We have previously described an antigen-specific I-Ad-restricted T-cell hybridoma, A1.1, that constitutively releases an antigen-specific immunoregulatory activity into supernatants. Using retrovirally mediated gene transfer, we have found that transfer of the T-cell receptor alpha chain (TCR alpha) gene from A1.1 to a number of other T-cell hybridomas effectively transferred the ability to produce the activity. Gene transfer of the TCR beta chain (TCR beta), however, did not transfer this ability. The regulatory activity from cells expressing the A1.1 TCR alpha bound to and was eluted from an anti-TCR alpha monoclonal antibody and displayed fine antigenic specificity identical to that of supernatants from A1.1. The possibility that this activity represents a secreted form of the TCR alpha (as opposed to shed cell-surface TCR) was examined in BW1100 cells, lacking TCR alpha and TCR beta, which produced the antigen-specific activity after gene transfer of the A1.1 TCR alpha gene. The expression of the immunoregulatory activity in supernatants correlated with a direct antigen-binding activity as detected by ELISA, thus raising the possibility that antigen binding is relevant to the mechanism of action of the soluble TCR alpha. We discuss these observations and our earlier studies suggesting an immunoregulatory role for soluble TCR alpha.
Synthetic baseline navigation using phase-coherent acoustic communication signals (2019)

The development of a synthetic baseline navigation technique that self-localizes an autonomous underwater vehicle (AUV) using intermittent acoustic communications signals received by a single transducer is described, along with field results from in-ocean tests. The method uses the phase measurement at the output of a second-order phase-locked loop to create fine-scale pseudorange estimates in addition to, or in the absence of, a one-way travel time measurement based on the arrival time of the acoustic data packet. These range measurements are incorporated by an adaptive particle filter. This technique allows the vehicle navigation system to take advantage of multiple phase-derived range measurements made over the duration of a communication packet. These measurements, when incorporated with an appropriate filter and vehicle kinematic model, improve vehicle navigation at no additional cost in navigation-specific acoustic transmissions. This approach was demonstrated and evaluated with data collected at-sea using a REMUS 100 AUV (Hydroid, Inc., Pocasset, MA).
Fibre-optic variable delay lines (1982)

A technique is presented for fabricating large numbers of evanescently coupled taps on a single-mode fibre. An output fibre can be adjusted between any of the taps, resulting in a discretely variable delay. The concept was demonstrated with a 7 tap device which had a 2.5 ns delay between taps and a tap uniformity of ± 1.6 dB. A technique for making continuously variable delay lines is presented.
On the thermal stability of physical vapor deposited oxide-hardened nanocrystalline gold thin films (2015)

We describe a correlation between electrical resistivity and grain size for PVD synthesized polycrystalline oxide-hardened metal-matrix thin films in oxide-dilute (&amp;lt;5 vol. % oxide phase) compositions. The correlation is based on the Mayadas-Shatzkes (M-S) electron scattering model, predictive of grain size evolution as a function of composition in the oxide-dilute regime for 2 μm thick Au-ZnO films. We describe a technique to investigate grain boundary (GB) mobility and the thermal stability of GBs based on in situ electrical resistivity measurements during annealing experiments, interpreted using a combination of the M-S model and the Michels et al. model describing solute drag stabilized grain growth kinetics. Using this technique, activation energy and pre-exponential Arrhenius parameter values of Ea = 21.6 kJ/mol and Ao = 2.3 × 10−17 m2/s for Au-1 vol. % ZnO and Ea = 12.7 kJ/mol and Ao = 3.1 × 10−18 m2/s for Au-2 vol. % ZnO were determined. In the oxide-dilute regime, the grain size reduction of the Au matrix yielded a maximum hardness of 2.6 GPa for 5 vol. % ZnO. A combined model including percolation behavior and grain refinement is presented that accurately describes the composition dependent change in electrical resistivity throughout the entire composition range for Au-ZnO thin films. The proposed correlations are supported by microstructural characterization using transmission electron microscopy and electron diffraction mapping for grain size determination.
Solution-processed indium-free ZnO/SnO2 bilayer heterostructures as a low-temperature route to high-performance metal oxide thin-film transistors with excellent stabilities (2016)

The ZnO/SnO<sub>2</sub> bilayer TFTs exhibited outstanding electron mobilities and excellent electrical stabilities against a variety of bias stresses.
Measurement of translational displacement probabilities by NMR: An indicator of compartmentation (1990)

We introduce and demonstrate an NMR pulsed gradient stimulated echo method of directly obtaining the molecular translational displacement probability (displacement profile) of a liquid. The temporal development of the displacement profile reflects the presence of diffusion, restrictions to diffusion (e.g., walls, membranes), flow, and spatially dependent relaxation sinks. This approach allows the study of compartments which are too small to be observed by conventional NMR imaging methods. The distribution of spatial properties of compartments can be characterized over a spatial field of about 0.1 to 25 microns, completely independent of the absolute spatial location of the individual compartments.
A Measurement of the Total Hadronic π⁻ on Argon Cross Section in the Kinetic Energy Range from 0.2–1 Giga-Electron Volts in a Liquid Argon Time Projection Chamber (2020)

The liquid argon time projection chamber (LArTPC) technology offers fine-grained tracking along with excellent calorimetric and particle identification capabilities, making it a powerful tool for experimental neutrino physics. Thus, the LArTPC has become the technology of choice for studying neutrino oscillations over short (&lt; 1 km) and long (&gt; 1000 km) baselines by experiments such as MicroBooNE, SBND, ICARUS, and DUNE. The LArIAT (Liquid Argon in a Test-beam) experiment exposes a LArTPC to a controlled beam of charged particles at the Fermilab Test Beam Facility to perform calibration studies and measurements of charged hadron–argon cross sections, with the goal of helping to reduce systematic uncertainties in LArTPC-based neutrino experiments. This work presents a measurement of the total hadronic π⁻–Ar cross section in the kinetic energy range from 0.2 GeV to 1 GeV, using data from the LArIAT experiment.
Soluble Tissue Factor Induces Coagulation on Tumor Endothelial Cells In Vivo if Coadministered With Low-Dose Lipopolysaccharides (2003)

To our knowledge, this is the first report to describe the molecular mechanisms of coagulation induction by untargeted soluble tissue factor in vivo. Combination treatments including soluble tissue factor might represent an alternative vascular targeting approach for the treatment of malignant tumors.
JPEG 2000 Application in GIS and Remote Sensing (2009)

This chapter contains sections titled: Introduction Geographic Information Systems Recommendations for JPEG 2000 Encoding Other JPEG 2000 Parts to Consider References
Detection of HIV-1 Matrix Protein p17 Quasispecies Variants in Plasma of Chronic HIV-1–Infected Patients by Ultra-Deep Pyrosequencing (2014)

On the whole, our data show that the intrapatient level of sequence diversity in the p17MA is much higher than predicted before. Our results pave the way for further studies aimed at unraveling possible correlations between the presence of distinct p17MA variants and peculiar clinical evolutions of HIV-1 disease. The presence of p17MA quasispecies diversity may offer new tools to improve our understanding of the viral adaptation during the natural history of HIV-1 infection.
Clinical Results with Nonthoracotomy ICD Systems (1993)

The results of two separate US Food and Drug Administration clinical trials that involved endocardial and epicardial leads were compared with regard to patient demographics, detection and conversion characteristics, and subsequent clinical course including long-term survival experience. The patient groups, although not strictly contemporaneous, were sufficiently similar to allow meaningful comparisons. There were no significant differences in detection of induced arrhythmias and ability to convert them. The surgical mortality, infection rate, and incidence of other morbid complications were lower in patients who had received endocardial leads; however, the differences did not reach statistical significance. Survivals through 1 year of follow-up were uniformly high. These results suggest that the performance of the endocardial lead system is comparable to existing epicardial leads in similar patient populations.
Production of nanograined intermetallics using high-pressure torsion (2013)

Formation of intermetallics is generally feasible at high temperatures when the lattice diffusion is fast enough to form the ordered phases. This study shows that nanograined intermetallics are formed at a low temperature as 573 K in Al- 25 mol% Ni, Al- 50 mol.% Ni and Al- 50 mol% Ti powder mixtures through powder consolidation using high-pressure torsion (HPT). For the three compositions, the hardness gradually increases with straining but saturates to the levels as high as 550-920 Hv. In addition to the high hardness, the TiAl material exhibits high yield strength as ~3 GPa with good ductility as ~23%, when they are examined by micropillar compression tests. X-ray diffraction analysis and high-resolution transmission electron microscopy reveal that the significant increase in hardness and strength is due to the formation of nanograined intermetallics such as Al3Ni, Al3Ni2, TiAl3, TiAl2 and TiAl with average grain sizes of 20-40 nm.
P‐39: Degradation Mechanism of Spindt‐Type Molybdenum Field Emitter Arrays by Oxidation and Surface Chemical Modification (2000)

Abstract Oxidation and chemical modification of molybdenum micro tip surface have been investigated to understand the performance degradation mechanism of field emitter arrays(FEAs). Molybdenum FEAs could be easily oxidized due to their interaction with oxygen‐containing species including O 2 , CO 2 and H 2 O during cathode fabrication or thermal sealing processes of field emission displays(FEDs). During device operation, outgassing from phosphors due to electron‐stimulated desorption and from other components inside a panel such as cathode, spacers, and sealant can lead to the chemical modification of the emitter surface. The oxidation and chemical modification of the emitter surface degrade the emission characteristics, resulting in the instability of an emission current, an increase of an electron extraction voltage for a given current, and lifetime reduction of the device. After the vacuum sealing and operation of the FED device, a micro tip is observed, and compared with an as‐grown one by using scanning electron microscopy(SEM) and transmission electron microscopy(TEM). Chemical composition analyses of the degraded emitter surface by nano‐probed Auger electron spectroscopy(AES) suggest that molybdenum micro tip is contaminated with S, In, C, and O after the device operation, where S and In seem to originate from the dissociation of phosphors by electron bombardment.
A Novel Class of Biotherapeutics Co-Targeting Cancer Cells and the Associated Tumor Neovasculature (2005)

s: Abstracts for the 20th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (Primary Authors are Italicized): NEW AGENTS IN DEVELOPMENT
Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire (2014)

Rabbits have been used extensively as a model system for the elucidation of the mechanism of immunoglobulin diversification and for the production of antibodies. We employed Next Generation Sequencing to analyze Ig germline V and J gene usage, CDR3 length and amino acid composition, and gene conversion frequencies within the functional (transcribed) IgG repertoire of the New Zealand white rabbit (Oryctolagus cuniculus). Several previously unannotated rabbit heavy chain variable (VH) and light chain variable (VL) germline elements were deduced bioinformatically using multidimensional scaling and k-means clustering methods. We estimated the gene conversion frequency in the rabbit at 23% of IgG sequences with a mean gene conversion tract length of 59±36 bp. Sequencing and gene conversion analysis of the chicken, human, and mouse repertoires revealed that gene conversion occurs much more extensively in the chicken (frequency 70%, tract length 79±57 bp), was observed to a small, yet statistically significant extent in humans, but was virtually absent in mice.
A way for a host to indicate support for 240.0.0.0/4 addresses (2009)

This document describes how in certain deployment scenarios the
240.0.0.0/4 address space can be taken into use in incremental and
backwards compatible manner.
Iridium-Catalyzed Asymmetric Hydrogenation of BenzophenoneN-H Imines (2010)

The authors presented a direct, protection-free approach to the synthesis of chiral diarylmethylamines by asymmetric hydrogenation of benzophenone N-H imines. By using commercially accessible, low-cost chiral monodentate phosphoramidite ligands, chiral diarylmethylamine derivates were obtained with high yield and enantioselectivity.
Communication par Affiche : "Elaboration de piles à combustible à membrane échangeuse de protons par voie plasma" (2006)

Colloque Energie 2006, 21-23 Novembre, Aix les Bains, France
TTI ASSISTS IN ESTABLISHING NEW UTILITY SAFETY PROGRAM (2001)

Research into the safety of utility poles is producing strategies for making them less likely to cause serious damage when vehicles collide with them. Full-scale crash tests at the Texas Transportation Institute show items that are more forgiving, but implementation requires cooperation with utility companies and setting priorities for installation.
Extending LTE coverage for machine type communications (2015)

In 4G Long-Term Evolution (LTE), numerous features for supporting machine type communications have been introduced. For wide area deployment, ubiquitous coverage is an important requirement. In Rel-13 of LTE specifications, coverage enhancement feature is being introduced. This feature will significantly extend LTE cell coverage to provide services to machines that are installed indoors or in coverage holes. In addition, it can also be used to ensure coverage to low-cost devices with reduced capabilities. In this paper, we provide an overview of this feature including potential enhancement techniques, link and system performance analysis, and impact to battery life. Techniques for future enhancement are also discussed.
Synthesis and biological evaluation of novel technetium-99m-labeled phenylquinoxaline derivatives as single photon emission computed tomography imaging probes targeting β-amyloid plaques in Alzheimer's disease (2017)

The development of an imaging probe targeting β-amyloid (Aβ) plaques in Alzheimer's disease labeled with technetium-99m, the most commonly used radioisotope for clinical diagnoses, has been strongly anticipated.
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling (2020)

Our findings suggest TNO155 is an effective agent for blocking both tumor-promoting and immune-suppressive RTK signaling in RTK- and MAPK-driven cancers and their tumor microenvironment. Our data provide the rationale for evaluating these combinations clinically.
Antisense oligonucleotides to therapeutically target SARS-CoV-2 infection (2023)

Although the COVID-19 pandemic began over three years ago, the virus responsible for the disease, SARS-CoV-2, continues to infect people across the globe. As such, there remains a critical need for development of novel therapeutics against SARS-CoV-2. One technology that has remained relatively unexplored in COVID-19 is the use of antisense oligonucleotides (ASOs)-short single-stranded nucleic acids that bind to target RNA transcripts to modulate their expression. In this study, ASOs targeted against the SARS-CoV-2 genome and host entry factors, ACE2 and TMPRSS2, were designed and tested for their ability to inhibit cellular infection by SARS-CoV-2. Using our previously developed SARS-CoV-2 bioassay platform, we screened 180 total ASOs targeting various regions of the SARS-CoV-2 genome and validated several ASOs that potently blocked SARS-CoV-2 infection in vitro. Notably, select ASOs retained activity against both the WA1 and B.1.1.7 (commonly known as alpha) variants. Screening of ACE2 and TMPRSS2 ASOs showed that targeting of ACE2 also potently prevented infection by the WA1 and B.1.1.7 SARS-CoV-2 viruses in the tested cell lines. Combined with the demonstrated success of ASOs in other disease indications, these results support further research into the development of ASOs targeting SARS-CoV-2 and host entry factors as potential COVID-19 therapeutics.
Positive-Congruent Training: Towards Regression-Free Model Updates (2020)

Reducing inconsistencies in the behavior of different versions of an AI system can be as important in practice as reducing its overall error. In image classification, sample-wise inconsistencies appear as "negative flips": A new model incorrectly predicts the output for a test sample that was correctly classified by the old (reference) model. Positive-congruent (PC) training aims at reducing error rate while at the same time reducing negative flips, thus maximizing congruency with the reference model only on positive predictions, unlike model distillation. We propose a simple approach for PC training, Focal Distillation, which enforces congruence with the reference model by giving more weights to samples that were correctly classified. We also found that, if the reference model itself can be chosen as an ensemble of multiple deep neural networks, negative flips can be further reduced without affecting the new model's accuracy.
Faculty Opinions recommendation of The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions. (2010)

Estrogen-related receptor alpha (ERRalpha) and proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) play central roles in the transcriptional control of energy homeostasis, but little is known about factors regulating their activity. Here we identified the homeobox protein prospero-related homeobox 1 (Prox1) as one such factor. Prox1 interacts with ERRalpha and PGC-1alpha, occupies promoters of metabolic genes on a genome-wide scale, and inhibits the activity of the ERRalpha/PGC-1alpha complex. DNA motif analysis suggests that Prox1 interacts with the genome through tethering to ERRalpha and other factors. Importantly, ablation of Prox1 and ERRalpha have opposite effects on the respiratory capacity of liver cells, revealing an unexpected role for Prox1 in the control of energy homeostasis. PMID: 20194433 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: R01 DK081457-02 NIDDK NIH HHS, United States Grant ID: R01 DK081457 Canadian Institutes of Health Research, Canada Grant ID: MOP-84227 Canadian Institutes of Health Research, Canada Grant ID: MOP-77763
Reconfigurable near-IR metasurface based on Ge2Sb2Te5 phase-change material (2018)

A reconfigurable metasurface made of Ge2Sb2Te5 phase-change material was experimentally demonstrated in the 1.55 μm wavelength range. A nanostructured Ge2Sb2Te5 film on fused silica substrate was optimized to switch from highly transmissive (80%) to highly absorptive (76%) modes with a 7:1 contrast ratio in transmission independent of polarization, when thermally transformed from the amorphous to crystalline state. The metasurface was designed using a genetic algorithm optimizer linked with an efficient fullwave electromagnetic solver.
Time-lapse videomicroscopy of HT-29 colonic cancer cells treated with CDDP from A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer (2023)

&lt;p&gt;Video 2 shows that HT-29 cells treated with 8 microM CDDP still proliferated and generated large cell clusters.&lt;/p&gt;