gebhart/patrepeval huggingface dataset:
Graphene Materials and Their Use in Dye-Sensitized Solar Cells (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTGraphene Materials and Their Use in Dye-Sensitized Solar CellsJoseph D. Roy-Mayhew†‡ and Ilhan A. Aksay†*View Author Information† Department of Chemical & Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States‡ Vorbeck Materials Corporation, 8306 Patuxent Range Road Suite 103, Jessup, Maryland 20794, United States*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 12, 6323–6348Publication Date (Web):May 9, 2014Publication History Received30 July 2013Published online9 May 2014Published inissue 25 June 2014https://pubs.acs.org/doi/10.1021/cr400412ahttps://doi.org/10.1021/cr400412areview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views9641Altmetric-Citations368LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electrodes,Layers,Materials,Oxides,Two dimensional materials Get e-Alerts
Improving Seawater Desalination with Nanocomposite Membranes (2010)

Reverse osmosis (RO) is the leading process for brackish and seawater desalination and freshwater purification. Membrane performance characteristics translate directly to the energy intensity and capital expenditures of an RO system and, therefore, to the economics of desalination. This article examines nanocomposite RO membranes and compares their performance to other commercially available products.
Microbial enhanced oil recovery research (1990)

In the previous quarterly report we described the criteria for selecting a microorganism for Microbial Enhanced Oil Recovery studies. After careful consideration we chose Bacillus licheniformis JF-2 because of its ability to withstand reservoir conditions and the production of a surface active lipopeptide. Detailed experiments were conducted in stirred tank fermenters equipped with pH control and constant sparging of air or, in the case of anaerobic experiments, O{sub 2}-free nitrogen. The effect of temperature and pH on biomass production, glucose consumption and interfacial tension against decane were determined for both aerobic and anaerobic conditions. 5 figs., 2 tabs.
Advances in Fan Modeling: Issues and Effects on Thermal Design of Electronics (2012)

Forced convection air-cooled electronic systems consist of fans to provide fluid flow through the enclosure. Typically axial flow fans, radial impellers, and centrifugal blowers fall into this category. In numerical computations of flow fields in electronic enclosures, axial fans have most commonly been abstracted as planar (2-D) rectangular or circular surfaces. In some cases, these abstract or lumped models may be used to mimic impellers and centrifugal blowers as well. All of these models rely on an experimentally derived “pressure head-flow rate” (P-Q) curve (also called “fan curve”). The experiments to obtain the fan curve should conform to the test codes published by ASME and/or AMCA. Convenience and accuracy of abstract fan models are dependent on the specific application/cooling method and the acceptable error margin. The latter for the thermal design of electronics has recently diminished considerably which led to the need of using more accurate and robust fan modeling techniques such as Multiple Reference Frame (MRF) model. The authors validated this method for different types of fans against relevant experimental data previously [1,2]. As a continuation of this earlier effort, an attempt is made to examine the thermal field computed by various fan modeling techniques including MRF for air-cooled enclosures in the present work. The results show that the temperature values obtained from lumped fan model and the MRF technique differ considerably.
Inhibition of cardiolipin biosynthesis in the hypoxic rat heart (1995)

Cardiolipin is the principal polyglycerophospholipid in the heart. The effect of hypoxia on cardiolipin biosynthesis was investigated in isolated rat hearts perfused in the Langendorff mode. Hearts were pulsed-labeled for 60 min with 0.1 mM [1,(3)-3H]glycerol in Krebs Henseleit buffer saturated with either 95% O2/5% CO2 (control) or 95% N2/5% CO2 (hypoxic). Radioactivity incorporated into phosphatidylglycerol and cardiolipin were reduced 88% (P < .05) and 79% (P < .05), respectively, in hypoxic hearts compared to controls. In other experiments, hearts were pulse-labeled for 15 min with 1.4 mM [32P]Pi in Krebs Henseleit buffer saturated with 95% O2/5% CO2 and subsequently perfused for 60 min under control or hypoxic conditions. The radioactivity incorporated into CDP-1,2-diacyl-sn-glycerol, phosphatidylglycerol, and cardiolipin were reduced 61% (P < .05), 71% (P < .05), and 70% (P < .05), respectively, in the hypoxic hearts compared to controls, indicating a decreased formation of CDP-1,2-diacyl-sn-glycerol in the hypoxic heart. The activities of the enzymes involved in cardiolipin biosynthesis and the cardiac pool sizes of cardiolipin, phosphatidylglycerol, and CDP-1,2-diacyl-1,2-diacyl-sn-glycerol were unaltered between hypoxic and control hearts. In contrast, cardiac adenosine-5'-triphosphate and CPT levels were decreased 94% (P < .05) and 92% (P < .05), respectively, in hypoxic hearts compared to controls. We postulate that the biosynthesis of the cardiac polyglycerophospholipid cardiolipin may be inhibited by a decreased adenosine-5'-triphosphate and cytidine-5'-triphosphate level in the heart.
TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens (2022)

The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongasome protein in most Gram-negative bacterial rods. Here, we describe a third-generation MreB inhibitor (TXH11106) with enhanced bactericidal activity versus the Gram-negative pathogens <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, and <i>Pseudomonas aeruginosa</i> compared to the first- and second-generation compounds A22 and CBR-4830, respectively. Large inocula of these four pathogens are associated with a low frequency of resistance (FOR) to TXH11106. The enhanced bactericidal activity of TXH11106 relative to A22 and CBR-4830 correlates with a correspondingly enhanced capacity to inhibit <i>E. coli</i> MreB ATPase activity via a noncompetitive mechanism. Morphological changes induced by TXH11106 in <i>E. coli</i>, <i>K. pneumoniae</i>, <i>A. baumannii</i>, and <i>P. aeruginosa</i> provide further evidence supporting MreB as the bactericidal target of the compound. Taken together, our results highlight the potential of TXH11106 as an MreB inhibitor with activity against a broad spectrum of Gram-negative bacterial pathogens of acute clinical importance.
Persistent Human Papillomavirus Infection Is Associated with a Generalized Decrease in Immune Responsiveness in Older Women (2006)

The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA-negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group (>/=65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect.
The pro‐inflammatory environment in recalcitrant diabetic foot wounds (2008)

Lower extremity ulceration is one of the serious and long-term diabetic complications rendering a significant social burden in terms of amputation and quality-of-life reduction. Diabetic patients experience a substantial wound-healing deficit. These lesions are featured by an exaggerated and prolonged inflammatory reaction with a significant impairment in local bacterial invasion control. Experimental and clinical evidences document the deleterious consequences of the wound's pro-inflammatory phenotype for the repair process. From a biochemical standpoint, hyperinflammation favours wound matrix degradation, thus, amplifying a pre-existing granulation tissue productive cells' invasiveness and recruitment deficit. Tumour necrosis factor perpetuates homing of inflammatory cells, triggers pro-apoptotic genes and impairs reepithelialisation. Advanced glycation end-products act in concert with inflammatory mediators and commit fibroblasts and vascular cells to apoptosis, contributing to granulation tissue demise. Therapeutic approaches aimed to downregulate hyperinflammation and/or attenuate glucolipotoxicity may assist in diabetic wound healing by dismantling downstream effectors. These medical interventions are demanded to reduce amputations in an expanding diabetic population.
PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas (2015)

Oncogenic PIK3CA mutations are common in HER2/neu-amplified USC and may constitute a major mechanism of resistance to trastuzumab treatment.
Modelling of Photoactive Pigments. Investigations of Polymorphism Using the Dreiding Force Field (1992)

Abstract The role of polymorphism in controlling the properties of organic photoconductors is central to the design of such materials. Insights into this problem may be gleaned through molecular modelling. This paper describes studies aimed at modelling crystal structures for a series of perylene photoactive pigments with the DREIDING force field. Extensions of this method to understanding polymorphism of these photogenerators are also discussed. Key Words: molecular modelingpolymorphismorganic photoconductorsperylene pigments
Towards High-Quality Large-Area Single-Crystalline Monolayer Graphene: the Critical Role of the Metal Template (2016)

status: Published
Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat) (2011)

ITF2357 (givinostat) is a histone deacetylase inhibitor with antiinflammatory properties at low nanomolar concentrations. We report here a phase I safety and pharmacokinetics trial in healthy males administered 50, 100, 200, 400 or 600 mg orally. After 50 mg, mean maximal plasma concentrations reached 104 nmol/L 2 h after dosing, with a half-life of 6.9 h. After 100 mg, maximal concentration reached 199 nmol/L at 2.1 h with a half-life of 6.0 h. Repeat doses for 7 consecutive days of 50, 100 or 200 mg resulted in nearly the same kinetics. There were no serious adverse effects (AEs) and no organ toxicities. However, there was a dose-dependent but transient fall in platelets. After 7 daily doses of 50 or 100 mg, the mean decrease in platelets of 17 and 25% was not statistically significant and returned to baseline within 14 d. Blood removed from the subjects after oral dosing was cultured ex vivo with endotoxin, and the release of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-1Ra, interferon (IFN)-γ and IL-10 was determined. Maximal reduction in IL-1β, TNFα, IL-6 and IFNγ was observed 4 h after dosing but returned to baseline at 12 h. There was no significant reduction in IL-1Ra or IL-10. With daily dosing, the fall in cytokine production in blood cultures observed on day 7 was nearly the same as that of the first day. We conclude that dosing of 50 or 100 mg ITF2357 is safe in healthy humans and transiently but repeatedly reduces the production of proinflammatory cytokines without affecting production of antiinflammatory cytokines.
Enhancement-mode n-channel TFT and room-temperature near-infrared emission based on n+/p junction in single-crystalline GeSn on transparent substrate (2017)

We demonstrated an integration of enhancement-mode single-crystalline n-channel thin-film transistor (TFT) and n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /p diodes for light detection/emission based on the single-crystalline GeSn alloy grown on a transparent substrate. Owing to the excellent crystal quality of GeSn layer and a high-quality n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /p junction, a record-high electron mobility of 271 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs and a room-temperature near-infrared electroluminescence (EL) were achieved. The present technology will offer an ideal platform for future GeSn-based optoelectronic integration.
Time-memory trade-offs for index calculus in genus 3 (2015)

Abstract In this paper, we present a variant of Diem's <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:mover> <m:mi>O</m:mi> <m:mo>˜</m:mo> </m:mover> <m:mrow> <m:mo>(</m:mo> <m:mi>q</m:mi> <m:mo>)</m:mo> </m:mrow> </m:mrow> </m:math> ${\widetilde{O}(q)}$ index calculus algorithm to attack the discrete logarithm problem (DLP) in Jacobians of genus 3 non-hyperelliptic curves over a finite field 𝔽 q . We implement this new variant in C++ and study the complexity in both theory and practice, making the logarithmic factors and constants hidden in the O ˜-notation precise. Our variant improves the computational complexity at the cost of a moderate increase in memory consumption, but we also improve the computational complexity even when we limit the memory usage to that of Diem's original algorithm. Finally, we examine how parallelization can help to reduce both the memory cost per computer and the running time for our algorithms.
Quarter- and sub-quarter-micron optical lithography (2002)

Will optical lithography finally have reached its ultimate limit at a quarter micrometer minimum feature size? The author shows the obstacles in the projection and the resist systems that prevent optical lithography from performing at its theoretical limit as well as means to further extend the theoretical limit. The requirements on the mask, the projection optics, the resist, and the alignment system to support quarter-and sub-quarter-micrometer optical lithography are covered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
3-D statistical channel model for millimeter-wave outdoor mobile broadband communications (2015)

This paper presents an omnidirectional spatial and temporal 3-dimensional statistical channel model for 28 GHz dense urban non-line of sight environments. The channel model is developed from 28 GHz ultrawideband propagation measurements obtained with a 400 megachips per second broadband sliding correlator channel sounder and highly directional, steerable horn antennas in New York City. A 3GPP-like statistical channel model that is easy to implement in software or hardware is developed from measured power delay profiles and a synthesized method for providing absolute propagation delays recovered from 3-D ray-tracing, as well as measured angle of departure and angle of arrival power spectra. The extracted statistics are used to implement a MATLAB-based statistical simulator that generates 3-D millimeter-wave temporal and spatial channel coefficients that reproduce realistic impulse responses of measured urban channels. The methods and model presented here can be used for millimeter-wave system-wide simulations, and air interface design and capacity analyses.
2‐Amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles with Microtubule‐Disruptive, Centrosome‐Declustering, and Antiangiogenic Effects in vitro and in vivo (2022)

A series of fifteen 2-amino-4-aryl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitriles (1 a-o) were synthesized via a three-component reaction of 4-hydroxycoumarin, malononitrile, and diversely substituted benzaldehydes or pyridine carbaldehydes. The compounds were tested for anticancer activities against a panel of eight human tumor cell lines. A few derivatives with high antiproliferative activities and different cancer cell specificity were identified and investigated for their modes of action. They led to microtubule disruption, centrosome de-clustering and G2/M cell cycle arrest in 518 A2 melanoma cells. They also showed anti-angiogenic effects in vitro and in vivo.
Network-Assisted MPTCP: Use Cases, Deployment Scenarios and Operational Considerations (2016)

Network-Assisted MPTCP deployment models are designed to facilitate
the adoption of MPTCP for the establishment of multi-path
communications without making any assumption about the support of
MPTCP by the communicating peers. MPTCP Conversion Points (MCPs)
located in the network are responsible for establishing multi-path
communications on behalf of endpoints, thereby taking advantage of
MPTCP capabilities to achieve different goals that include (but are
not limited to) optimization of resource usage (e.g., bandwidth
aggregation), of resiliency (e.g., primary/backup communication
paths), and traffic offload management. This document describes
Network-Assisted MPTCP uses cases, deployment scenarios, and
operational considerations.
Autonomous Electrolyte Discovery for Batteries with Experimentally Informed Bayesian Optimization (2020)

An autonomous battery electrolyte experimental platform capable of mixing multi-component electrolyte systems and characterizing the transport and electrochemical properties in a high-throughput manner is disclosed. A Bayesian optimization software package found novel electrolyte compositions through optimization of the high-dimensional electrolyte design space over key design objectives like electrochemical stability and conductivity. Electrolyte optimization is difficult because 1) electrolyte evaluation is expensive and takes time, and 2) the space of possible electrolytes is expansive, formed by many possible choices for solvents (often in ternary blends), salts (often in binary mixtures), and trace additives. Bayesian optimization methods are well suited for the optimization of high-dimensional functions with costly evaluations, often producing an efficient design-of-experiments to converge on multi-objective optimal formulations in few experiments. To expedite the optimization over the expansive design space, theoretical predictions of electrolyte properties via the Advanced Electrolyte Model were utilized as “priors” in the statistical model. Implementation of the novel experimental platform was carried out by two novel test stands developed to automate the mixing and characterization of electrolytes: Otto (for aqueous systems) and Clio (for aprotic/organic systems). The test stands characterized the ionic conductivity and electrochemical stability of electrolyte systems, featuring a four-electrode conductivity probe, pH meter, and a flow-through three-electrode cell and potentiostat. Clio also integrated electrochemically active electrodes for optimization of electrolyte/electrode systems. The active electrode systems used were common functional ceramic metal oxides. A software orchestration and data layer linked the test-stands to human experimenters and machine-learning packages through a web-services architecture; all experiment data and meta-data is saved in a database. Additional out-of-the-loop characterization was conducted on cathodic systems to validate composition, structure, and oxidation state. The aqueous design space consisted of aqueous blends of lithium and sodium salts, including nitrates, sulfates, and other commonly-used battery salts. High-concentration aqueous electrolyte candidates were discovered by optimizing of electrochemical voltage stability and conductivity, including low-cost, high-performing alternatives to known but costly aqueous electrolytes (e.g. LiTFSI). Clio’s design space includes blends of both aprotic organic solvents and solutes in additional to various compositions of electrochemically active electrodes. The test-stands are demonstrated to be significantly faster than common human experimentation techniques, converging on novel, optimized electrolyte mixtures in mere hours or days of experimentation.
Supplementary Data from Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors (2023)

&lt;p&gt;Supplementary Figures and Figure Legends&lt;/p&gt;
PolymoRF: Polymorphic Wireless Receivers Through Physical-Layer Deep Learning (2020)

Today's wireless technologies are largely based on inflexible designs, which makes them inefficient and prone to a variety of wireless attacks. To address this key issue, wireless receivers will need to (i) infer on-the-fly the physical-layer parameters currently used by transmitters; and if needed, (ii) change their hardware and software structures to demodulate the incoming waveform. In this paper, we introduce PolymoRF, a deep learning-based polymorphic receiver able to reconfigure itself in real time based on the inferred waveform parameters. Our key technical innovations are (i) a novel embedded deep learning architecture, called RFNet, which enables the solution of key waveform inference problems; (ii) a generalized hardware/software architecture that integrates RFNet with radio components and signal processing. We prototype PolymoRF on a custom software-defined radio platform, and show through extensive over-the-air experiments that (i) RFNet achieves similar accuracy to that of state-of-the-art yet with 52x and 8x latency and hardware reduction; (ii) PolymoRF achieves throughput within 87% of a perfect-knowledge Oracle system, thus demonstrating for the first time that polymorphic receivers are feasible and effective.