gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Non Thiazolidinedione Antihyperglycaemic Agents. Part 1. α‐ Heteroatom Substituted β‐Phenylpropanoic Acids. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification and characterization of <i>Camellia sinensis</i> glucosyltransferase, UGT73A17: A possible role in flavonol glucosylation (2014)

Tea plant (Camellia sinensis) biosynthesizes a wide variety of specialized metabolites, including phenolic compounds such as catechins. Flavonol, one of the major flavonoid subclasses, in C. sinensis is present in the O-glycoside form, such as quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, and rutin (quercetin 3-O-β-glucopyranosyl-6-O-α-rhamnoside). These flavonol glycosides are highly accumulated, constituting up to 2–3% (w/w dry weight) of tea leaves; however, their biosynthetic machinery in C. sinensis remains elusive. Using high-throughput RNA sequencing from the fresh leaves of a cultivar (C. sinensis var sinensis cv Yabukita) and rapid amplification of cDNA ends (RACE) cloning with degenerate oligonucleotide primers, we identified a full-length cDNA of UDP-glycosyltransferase, designated as UGT73A17, and characterized the biochemical and molecular functions of UGT73A17. Recombinant UGT73A17 protein catalyzed 3-O-glucosylation of quercetin, yielding quercetin 3-O-β-D-glucopyranoside in vitro. The preferential expression of UGT73A17 gene in the mature, relative to young leaves, stems and roots, is roughly consistent with the accumulation pattern of flavonol glycosides in C. sinensis, suggesting that UGT73A17, in part, participates in the biosynthesis of flavonol glycosides in planta.
Polypeptides by light: photo-polymerization of N-carboxyanhydrides (NCA) (2016)

Synthesis of well-defined synthetic polypeptides by <italic>in situ</italic> UV-triggered formation of amine initiators.
Supplementary Table 3 from Identification of Promiscuous KIF20A Long Peptides Bearing Both CD4<sup>+</sup> and CD8<sup>+</sup> T-cell Epitopes: KIF20A-Specific CD4<sup>+</sup> T-cell Immunity in Patients with Malignant Tumor (2023)

&lt;p&gt;Supplementary Table 3 - PDF file 33K, Results of the immunohistochemical analysis of KIF20A in head and neck tumor&lt;/p&gt;
Transfemoral Transcatheter Mitral Valve Implantation With a Dedicated Device in a Rheumatic Mitral Stenosis Patient (2023)

A 65-year-old obese woman with rheumatic heart disease and restrictive lung disease presented with decompensated heart failure. Evaluation demonstrated severely thickened mitral valve leaflets, severe mitral stenosis, and moderate mitral regurgitation. She underwent successful transfemoral transseptal transcatheter mitral valve replacement with a dedicated valve resulting in improved functional status. (<b>Level of Difficulty: Advanced.</b>).
Temporal Alteration of Connexin43 Localization during Ultraviolet Light-induced Apoptosis (2004)

Although gap junctions are thought to play an important role in moderating apoptosis, the basic phenomena underlying when and where the alterations of gap junctions occur during apoptosis have not been well documented. In this study we analyzed the spatiotemporal changes of connexin (Cx) during UV light-induced apoptosis using Cx43-enhanced green fluorescent protein (EGFP)-expressing HeLa cells, and compared them with those of mitochondrial membrane potential (MMP) using tetramethylrhodamine ethyl ester (TMRE) and nuclear morphological observation using Hoechst 33342. At 2 hr post-UV-irradiation, a third of the cells were TMRE negative, i.e., they showed the loss of MMP, but with slight nuclear fragmentation, and high percentages of linear Cx43-EGFP plaques were found among both TMRE-positive and TMRE-negative cells. At 4 hr post-UV-irradiation, the percentage of these linear plaques was decreased, and both punctate and diffuse localization of Cx43-EGFP were noted in the cytoplasm of TMRE-negative cells without nuclear fragmentation. At 8 hr post-irradiation, punctate cytoplasmic localization of Cx43-EGFP was noted in TMRE-negative cells with nuclear fragmentation. Treatment with the caspase inhibitor Z-VAD-FMK blocked nuclear fragmentation and partially preserved both gap junctional plaques and MMP. These results indicate that, during apoptosis, Cx mobilization into the cytoplasm occurs after MMP depolarization but before nuclear fragmentation and that this alteration partly depends on caspase.
Transformation of Sugars into Chiral Polyols over a Heterogeneous Catalyst (2018)

Abstract Transformation of sugars, while maintaining the intrinsic stereochemical structure, is desirable. However, such a transformation requires multistep synthesis with protection and deprotection of the OH groups. Herein, a new method for selective transformation of sugar derivatives into chiral building blocks and a diol synthon, with retention of the intrinsic configuration (stereo‐ and regioselectively), is demonstrated. The method is based on the selective recognition of cis ‐vicinal OH groups in sugars and leads to the one‐pot removal of the cis ‐vicinal OH groups, without protection of OH groups (except the OH group of the hemiacetal group), over a heterogeneous CeO 2 ‐supported ReO x and Pd (ReO x ‐Pd/CeO 2 ) catalyst by using H 2 as a reducing agent.
M-phase Filtering and Duality (2013)

M-phase filters offer high-Q filtering by frequency translation of low-Q baseband impedances to the clock frequency. These filters are placed typically at high-impedance RF nodes, and the quality factor of the resulting bandpass filtering at the RF is proportional approximately to this impedance. Low-impedance RF nodes cannot benefit from these M-phase filters for the following two reasons: (a) for a given quality factor, the required baseband capacitors (and, therefore, the filter size) is inversely proportional to this impedance; (b) the attenuation of the filter at far-out frequencies is equal to the ratio of this impedance to the switch resistance. For low-impedance nodes, the far-out attenuation becomes insignificant.
Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase (2015)

Protein kinases are therapeutic targets for human cancer. However, "gatekeeper" mutations in tyrosine kinases cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target. Numerous small-molecule mTOR kinase inhibitors have been developed, with some already in human clinical trials. Given our clinical experience with targeted therapeutics, acquired drug resistance in mTOR is thought likely, but not yet documented. Herein, we describe identification of a hot spot (L2185) for drug-resistant mutations, which is distinct from the gatekeeper site, and a chemical scaffold refractory to drug-resistant mutations. We also provide new insights into mTOR kinase structure and function. The hot spot mutations are potentially useful as surrogate biomarkers for acquired drug resistance in ongoing clinical trials and future treatments and for the design of the next generation of mTOR-targeted drugs. Our study provides a foundation for further research into mTOR kinase function and targeting.
High performance wafer-fused semiconductor disk lasers emitting in the 1300 nm waveband (2014)

We report for the first time on the performance of 1300 nm waveband semiconductor disc lasers (SDLs) with wafer fused gain mirrors that implement intracavity diamond and flip-chip heat dissipation schemes based on the same gain material. With a new type of gain mirror structure, maximum output power values reach 7.1 W with intracavity diamond gain mirrors and 5.6 W with flip-chip gain mirrors, using a pump spot diameter of 300 µm, exhibiting a beam quality factor M(2)< 1.25 in the full operation range. These results confirm previously published theoretical modeling of these types of SDLs.
Thin Glass Substrates with Through-Glass Vias. (2019)

Abstract Glass substrates with fine-pitch through-glass via (TGV) technology is a promising approach to system in a package (SIP) integration. Millimeter wave applications, in particular, benefit from the superior RF properties, dimensional stability, and surface properties of glass. Glass can be made in very thin sheets (&amp;lt;200 um) which aids in integration and eliminates the need for back-grinding operations. The biggest challenge to adopting glass as a microelectronics packaging substrate is the existence of gaps in the supply chain, caused primarily by the difficulty in handling large, thin glass substrates using existing automation and processing equipment. This paper presents a temporary bonding technology that allows the substrates to be processed in a semiconductor fab environment without the need to modify existing equipment.
NovelWaferLevel Package Technology Studies forImageSensor Devices (2005)

WaferLevel Package foroptical imagesensor devices areknowntobeprocessed byre-routing ofthebondpads to thebackside ofthechip, through (T)contacts located atthe dieedges.Bondpadbackviacontact waferlevel packaging technology hasbeendeveloped by Schott Electronic Packaging GmbH,Germany, whichisproven to bewithanumberofadvantages overthemechanically processed (T) contact WaferLevelPackages. Direct contact ofthebondpadsfromthebacksideofthechip offers muchshorter transmission paths totheboard assemblies, thusallowing faster signal speed, efficient thermal conduction andmanyadded advantages. Also, the newtechnology offers areacontacts withintheseal ring / isolation boundary ofthedevice, there-by providing much higher performance forthepackaged devices. Thereliability ofthis newWLP technology hasbeendemonstrated by testing thesameforvarious reliability test conditions asper JEDEC/JISstandards. Thispaper discusses theprocess technology andreliability tests /results carried outona consumer application chip, namely image sensor device.
Gesture recognition using a probabilistic framework for pose matching (2004)

This paper presents an approach for view-based recognition of gestures. The approach is based on representing each gesture as a sequence of learned body poses. The gestures are recognized through a probabilistic framework for matching these body poses and for imposing temporal constrains between different poses. Matching individual poses to image data is performed using a probabilistic formulation for edge matching to obtain a likelihood measurement for each individual pose. The paper introduces a weighted matching scheme for edge templates that emphasize discriminating features in the matching. The weighting does not require establishing correspondences between the different pose models. The probabilistic framework also imposes temporal constrains between different pose through a learned Hidden Markov Model (HMM)for each gesture.
A boundary element analysis of flow in sheet molding compound (1988)

Abstract A new boundary element method has been developed for analyzing the flow of sheet molding compound (SMC) during compression molding. The boundary element equations can be used to determine the velocities on the perimeter of the charge. Successive flow front configurations are then generated by a simple explicit updating procedure. This approach was used to predict the flow front progression for elliptical, rectangular, and L‐shaped charges. Comparisons with experimental data for elliptical and rectangular charges were encouraging. The fact that it was possible to obtain reasonable agreement for charges with different shapes and thicknesses lends support to the underlying flow model. Furthermore, valuable insight regarding knit line formation was acquired by analyzing the L‐shaped charge. Results from the boundary element analysis showed that the initial thickness of the charge has a pronounced effect on knit line development. Even though there is considerable industrial experience in making SMC parts, the important role of charge thickness on knit line formation appears to have been largely overlooked. Prior analyses gave no indication of this effect because they were based on lubrication models that were independent of charge thickness.
Moxetumomab pasudotox and minimal residual disease in hairy cell leukemia. (2015)

7079 Background: Moxetumomab pasudotox is a recombinant immunotoxin containing truncated Pseudomonas exotoxin fused to an anti-CD22 Fv, reported to achieve 46% complete remissions in 28 relapsed/refractory hairy cell leukemia (HCL) patients treated with 5-50 ug/Kg every other day for 3 doses (QOD x3) per cycle. As a secondary endpoint of this phase I study, minimal residual disease (MRD) was studied in the original cohort and in an additional 21 patients enrolled at the highest dose level, amounting to 33 patients at 50 ug/Kg QOD x3. Methods: MRD studies included immunohistochemistry (IHC) of bone marrow biopsy (BMBx) and flow cytometry (FC) of blood and bone marrow aspirate (BMA). Real-time quantitative (RQ)-PCR, previously reported to detect 1 HCL cell in 106normal, used immunoglobulin rearrangement (IgH)-specific primers, when patient HCL IgH sequencing was possible. Results: Elimination of MRD by BMA FC, BMBx IHC and blood FC was achieved in 13 of 46 evaluable patients, 12 (36%) of 33 at 50 ug/Kg x3 and 1 (33%) of 3 at 40 ug/Kg QOD x3, vs 0 of 10 at lower doses (p = 0.04). Of 36 patients at 40-50 ug/Kg, those MRD-negative included 5 by blood FC, 1 by BMBx IHC, 5 by both blood FC and BMBx IHC, and 13 by all 3 studies. The median time to resolution of MRD in these 13 patients was 84 days, just prior to cycle 4. Of these 13 MRD-free patients, 11 (85%) remain MRD-free for 28-72 (median 45) months, and all 13 remain MRD-free in blood. In contrast, 7 of 10 patients MRD-free by blood but not BMA FC eventually became MRD+ in blood (p = 0.0005). RQ-PCR was more sensitive than BMA FC; of 19 patients evaluable for RQ-PCR, 5 of 6 MRD-free by BMA FC were also MRD-free by BMA RQ-PCR. Conclusions: Moxetumomab pasudotox can eradicate MRD in multiply relapsed HCL patients. We are aware of no other non-chemotherapy option with documented multi-year MRD-free BMA FC in a significant fraction of HCL patients. BMA MRD eradication is associated with lack of HCL progression in blood. Additional testing with RQ-PCR will determine if this more sensitive test is associated with outcome and can be used to help determine the optimal number of cycles. This study of investigator reported data was sponsored by MedImmune and supported by NCI’s Intramural Research Program and the Hairy Cell Leukemia Foundation. Clinical trial information: NCT00462189.
On Combining Shortest-Path and Back-Pressure Routing Over Multihop Wireless Networks (2010)

Back-pressure-type algorithms based on the algorithm by Tassiulas and Ephremides have recently received much attention for jointly routing and scheduling over multihop wireless networks. However, this approach has a significant weakness in routing because the traditional back-pressure algorithm explores and exploits all feasible paths between each source and destination. While this extensive exploration is essential in order to maintain stability when the network is heavily loaded, under light or moderate loads, packets may be sent over unnecessarily long routes, and the algorithm could be very inefficient in terms of end-to-end delay and routing convergence times. This paper proposes a new routing/scheduling back-pressure algorithm that not only guarantees network stability (throughput optimality), but also adaptively selects a set of optimal routes based on shortest-path information in order to minimize average path lengths between each source and destination pair. Our results indicate that under the traditional back-pressure algorithm, the end-to-end packet delay first decreases and then increases as a function of the network load (arrival rate). This surprising low-load behavior is explained due to the fact that the traditional back-pressure algorithm exploits all paths (including very long ones) even when the traffic load is light. On the other-hand, the proposed algorithm adaptively selects a set of routes according to the traffic load so that long paths are used only when necessary, thus resulting in much smaller end-to-end packet delays as compared to the traditional back-pressure algorithm .
Conditions leading to the establishment of the N (a gene dependent) and A (a gene independent) transformed states after polyoma virus infection of rat fibroblasts (1978)

Infection of normal rat fibroblasts (FR 3T3) with the early tsa mutant of polyoma virus may lead to either the A or the N phenotype, tsa-A transformants, originally derived by agar selection, are not temperature dependent for maintenance of the transformed phenotype, whereas tsa-N transormants revert at high temperature to normal growth control. A transformants did not result from an independent cellular mutation selected in agar medium, but rather from a transformation process distinct from that leading to the N state. It occurred in both liquid and agar media when the infected cells were maintained under growth-restricting conditions, such as absence of anchorage and contact inhibition at confluency. N transformation occurred in cells maintained in active growth after virus infection (sparse cultures on a solid substratum). Physiological conditions during a critical period after virus infection thus appear to be a crucial parameter of the transformation process.
Facile Polyolefin Plastics Hydrogenolysis Catalyzed by a Surface Electrophilic d0 Hydride (2021)

Polyolefins comprise a major fraction of single-use plastics and yet their catalytic deconstruction/recycling has proven challenging due to their inert hydrocarbon connectivities. Here an electrophilic earth-abundant single-site organozirconium catalyst chemisorbed on a highly Brønsted acidic support and characterized by a broad array of experimental and theoretical techniques, is shown to mediate the rapid hydrogenolytic cleavage of molecular and macromolecular saturated hydrocarbons under mild conditions. For n-hexadecane, hydrogenolysis to light hydrocarbons proceeds with an activity of 690 mol n-hexadecane · mol Zr-1 · h-1 at 150°C/2.5 atm H2 pressure. Under similar solventless conditions, polyethylene, polyethylene-co- 1-octene, isotactic polypropylene, and a post-consumer sandwich bag are rapidly hydrogenolyzed to low molecular mass hydrocarbons via a turnover-limiting C-C scission pathway involving ßalkyl transfer rather than more common σ-bond metathesis.
Proceedings of the 3rd Workshop on Data Center - Converged and Virtual Ethernet Switching (2011)

The traditional Data Center (DC) compute model, especially in the x86 space, has consisted of lightly utilized servers running a bare metal OS or a Hypervisor with a small number of Virtual Machines (VMs). In this traditional model, servers attach to the network lower bandwidth links, such as 1 Gbps Ethernet and 2 or 4 Gbps Fibre Channel. This physical compute model suffers from two major issues: High capital expenses due to under utilized servers and multiple fabrics; and High operational expenses due to manual administration of many management tools. As such, the management tasks have been focused on maintaining the infrastructure and not on the services that are provided by the infrastructure to the business.

In our view Data Centers are under going a major transition toward a Converged and Virtualized compute model. This new model allows for construction of flexible IT capability that enables the optimal use of compute and information to support business initiatives. This model has many highly utilized servers running many VMs per server, using high bandwidth links to communicate with virtual storage and virtual networks both within and across Data Center sites. For networking within the Data Center the potential value of this new model comes from: lowering capital expenses through higher utilization (server, storage and network), and converged fabrics; and lowering operational expenses through automated and integrated management that optimizes Data Center infrastructure. At the edge of the Data Center, virtual networking (e.g. MPLS, VPLS) also offers tremendous savings associated with combining networks, especially across the wide area network with its expensive WAN links.
Distributed Feedback Silicon Evanescent Laser (2008)

We report an electrically pumped distributed feedback silicon evanescent laser. The laser operates continuous wave with a single mode output at 1600 nm. The laser threshold is 25 mA with a maximum output power of 5.4 mW and a maximum operating temperature of 50 °C.
A microelectromechanically tunable asymmetric Fabry-Perot quantum well modulator at 1.55 µm (2008)

Placing a quantum well modulator in an asymmetric Fabry- Perot cavity enables significantly higher contrast ratios than are possible in a conventional surface-normal quantum well modulator. However, fixed-cavity asymmetric Fabry-Perot quantum well modulators require extremely precise and uniform crystal growth and are sensitive to small fluctuations in temperature or angle of incidence. Here, we experimentally demonstrate an InP-based microelectromechanically tunable asymmetric Fabry-Perot quantum well modulator that operates in the optical C-band. By actuating a suspended InGaAlAs reflector, the cavity mode can be perfectly matched to the appropriate quantum well absorption wavelength. The devices exhibit contrast ratios over 30 (15 dB) at 8 volts quantum well bias and modulation speeds of 1 MHz.
OP15.04: Novel AI‐guided ultrasound screening system for fetal heart can demonstrate findings in timeline diagram (2019)

We have developed a novel fetal cardiac screening system that is used deep leaning technology. This system can real-timely and automatically detect each part in fetal echocardiographic movie that was acquired in 2nd trimester cardiac screening examination. Artificial intelligence (AI) was based on convolutional neural networks. Whereas, the decision process of AI, especially deep learning, has been unexplainable and still in black box. Therefore, we tried to visualise and explain its process toward practical utilisation of our system in clinic. 42 normal fetal heart movies were used as a training dataset, and the experts had annotated the correct positions of 18 different parts of the heart and peripheral organs such as the atrium, ventricle, blood vessels and stomach. The fetal movie of tetralogy of Fallot (TOF) and transposition of the great arteries (TGA) were used as a test dataset. Each movie includes sequential axial views from the level of stomach to base of heart. AI described each part as barcode-used diagram along with the sweep scanning timeline. The diagram was demonstrated the detection probability of each part in each moment. The diagram clearly showed the abdomen part, heart structural part, and out flow tract/blood vessel part as like we observed in the sweep movie. In case of TOF, the pulmonary artery was not demonstrated clearly and in case of TGA, the detection pattern of out flow tract/blood vessel part was different from the normal fetal ones. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.