gebhart/patrepeval huggingface dataset:
Experience in setting thresholds for mechanical diagnostics in the UH-60L fleet demonstration (2005)

The UH-60L Fleet Management Demonstration Program is a two phase, two year program to gain operational experience with an integrated Health and Usage Monitoring System (HUMS). Thirty Sikorsky UH-60L BLACK HAWK aircraft of the 4th Battalion of the 101st Airborne Assault Division have been equipped with Goodrich IMD-HUMS and Aero System Sapphire maintenance management information system (MMIS). The program is aimed at evaluating the IMD-HUMS and MMIS, exploring the impact thereof on maintenance and assessing their feedback on overall fleet management and OEM engineering inputs. One of the functionalities of HUMS is the mechanical diagnostic monitoring of the helicopter drive train components, including main transmission and tail drive. The main requirement of mechanical diagnostics is to detect when a component degrades from a healthy state to an intermediate non-health and ultimately faulted condition. The mechanical diagnostic monitoring is typically accomplished by accelerometer based vibration monitoring, with respect to appropriate thresholds on features (condition indicators) derived from advanced vibration signal processing. A formal procedure for setting thresholds was previously present by the authors ("Setting HUMS Condition Indicator Thresholds by Modeling Aircraft and Torque Band Variance", E. Bechhoefer, A. Bernhard, 2003 IEEE Aerospace Conf). That approach focuses on setting thresholds based on controlling false alarm rate (in the absence of faulted data statistics). This paper presents the successful implementation of that approach to the thirty U-60L BLACK HAWK aircraft fleet and will evaluate the robustness and merit of the approach. Review of selected raw, time domain data is used to provide further insight into the evolution of condition indicators and the validity of the thresholds
Novel Transport Properties of Colonic Crypt Cells: Fluid Absorption and Cl-Dependent Na-H Exchange (1997)

Colonic ion transport is heterogeneous including the long-accepted spatial separation of absorptive and secretory processes between surface and crypt cells. We recently described the isolation of individual crypts from the rat distal colon that were studied using microperfusion technology. Na-dependent fluid absorption was consistently demonstrated in these crypts during perfusion with a Ringer-like solution; dibutyryl cyclic AMP, VIP and acetylcholine, when added to the bath solution, all induced net fluid secretion. As several morphologic techniques, including immunocytochemistry, failed to provide evidence for the presence of myofibroblasts in the isolated crypt preparation, we propose that a Na-dependent absorptive process is a constitutive transport mechanism in crypt cells, while secretory processes are regulated by the release of one or more neurohumoral agonists from lamina propria cells including myofibroblasts. The mechanism of Na-dependent fluid movement was also studied by determining [H] gradient stimulation of 22Na uptake in isolated apical membrane vesicles (AMV) from crypt cells. In contrast to Na-H exchange in surface cell AMV, Na-H exchange in crypt cells is Cl-dependent. Intracellular pH determined in crypt cells using video-imaging fluorescence microscopy established that the response to an acid load requires both lumen Na and Cl. As a result, these studies have identified a novel Cl-dependent Na-H exchange in crypt AMV that may mediate apical membrane Na uptake and regulate pHi.
Security of Future eEnabled Aircraft Ad hoc Networks (2008)

This paper focuses on security concerns with a future ad hoc network of data linked eEnabled airplanes, and proposes a framework to protect communications. The framework identifies emerging threats and vulnerabilities, specifies security requirements and mitigation solutions. Major security challenges anticipated in the ground infrastructure and eEnabled airplanes are presented along with some open problems.
Al-2.86 Numerical Aperture (2021)

As increasingly smaller molecular materials and material structures are devised or developed for technological applications, the demands on the processes of lithography now routinely include feature sizes that are of the order of 10 nm. In reaching such a fine level of resolution, the methods of lithography have increased markedly in sophistication and brought into play 2terminology that is unfamiliar, on the one hand, to scientists tasked with the development of new lithographic materials or, on the other, to the engineers who design and operate the complex equipment that is required in modern-day processing. Publications produced by scientists need to be understood by engineers and vice versa, and these commonly arise from collaborative research that draws heavily on the terminology of two or more of the traditional disciplines. It is developments in polymer science and material science that lead progress in areas that cross traditional boundaries, such as microlithography. This document provides the exact definitions of a selection of unfamiliar terms that researchers and practitioners from different disciplines might encounter.
Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules (1994)

The objective of this study was to identify the molecular determinants of leukocyte rolling, adherence, and emigration elicited in postcapillary venules by the lipid mediators leukotriene B4 (LTB4) or platelet-activating factor (PAF). Leukocyte-endothelial cell adhesion and shear rate were monitored in rat mesenteric venules during superfusion with either LTB4 or PAF in the presence or absence of monoclonal antibodies (MAbs) directed against either leukocyte (CD18, CD11b) or endothelial cell [intercellular adhesion molecule 1 (ICAM-1), E-selectin, P-selectin] adhesion glycoproteins. In untreated animals and in animals receiving a nonbinding control MAb, LTB4 and PAF increased the number of both adherent (8- and 4-fold, respectively) and emigrated (14- and 8-fold, respectively) leukocytes, while reducing leukocyte rolling velocity (36 and 33%, respectively). The LTB4- and PAF-induced leukocyte adherence and emigration were significantly attenuated by pretreatment with MAbs directed against CD18, CD11b, ICAM-1, and E-selectin, but not P-selectin. The reduction in leukocyte rolling velocity induced by LTB4 was not affected by any of the MAbs; however, both P- and E-selectin MAbs significantly attenuated the reduction in leukocyte rolling velocity elicited by PAF. The results of this study indicate that the leukocyte adherence and emigration induced by both LTB4 and PAF are mediated by CD11b/CD18 on leukocytes and by ICAM-1 and E-selectin on endothelial cells. The molecular determinant of leukocyte rolling appears to be mediator specific, with the selectins mediating the rolling elicited by PAF.
Development of molecular genetic methods for monitoring myeloid malignancies (1993)

The malignant diagnosis of a haematological disorder can in most cases be made by clinical signs and routine microscopic examination. However, it has become necessary to characterize the malignant clone with various markers, which give either knowledge of the prognosis of the disease or give tools for the laboratory follow up of the patient.In lymphatic diseases there are excellent markers of clonality. On the contrary in myeloid malignancies the few well characterized markers are mostly helpful in the clinical management of rare myeloid subgroups. The aim of our project has been to develop methods for laboratory monitoring of myeloid diseases by two major approaches 1) detection of methylation alterations in the short arm of chromosome 11 and 2) novel approaches for sensitive point mutation detection.The short arm of chromosome 11 has areas where the DNA becomes hyper-methylated in acute leukemias and lymphomas. In this chromosomal area the calcitonin gene serves as a good marker for methylation alterations due to several CpG sites in the 5′area of the gene. Even if the gene is normally methylated in most cases of chronic myeloid leukemia (CML), we have found that the hypermethylation of the calcitonin gene marks progression of CML and precedes any other signs of acceleration with several months.The point mutations of certain proto-oncogenes, such as the N-ras gene, are attractive markers for detecting residual diseases after chemotherapy of high malignant haematological disorders. However, conventional methods for detecting point mutations have been both insensitive and cumbersome, and thus unsuitable for clinical routine laboratories. With the solid-phase minisequencing we can technically easily and accurately detect small quantities of mutated cells.
Performance Comparison of Three Chemical Vapor Deposited Aminosilanes in Peptide Synthesis: Effects of Silane on Peptide Stability and Purity (2018)

Silicon oxide substrates underwent gas-phase functionalization with various aminosilanes, and the resulting surfaces were evaluated for their suitability as a solid support for solid phase peptide synthesis (SPPS). APTES (3-aminopropyltriethoxysilane), APDEMS (3-aminopropyldiethoxymethylsilane), and APDIPES (3-aminopropyldiisopropylethoxysilane) were individually applied to thermal oxide-terminated silicon substrates via gas-phase deposition. Coated surfaces were characterized by spectroscopic ellipsometry (SE), contact angle goniometry, X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and spectrophotometry. Model oligopeptides with 16 residues were synthesized on the amino surfaces, and the chemical stabilities of the resulting surfaces were evaluated against a stringent side chain deprotection (SCD) step, which contained trifluoroacetic acid (TFA) and trifluoromethanesulfonic acid (TFMSA). Functionalized surface thickness loss during SCD was most acute for APDIPES and the observed relative stability order was APTES > APDEMS > APDIPES. Amino surfaces were evaluated for compatibility with stepwise peptide synthesis where complete deprotection and coupling cycles are paramount. Model trimer syntheses indicated that routine capping of unreacted amines with acetic anhydride significantly increased purity as measured by MALDI-MS. An inverse correlation between the amine loading density and peptide purity was observed. In general, peptide purity was highest for the lowest amine density APDIPES surface.
62‐11: Development of New Green Phosphors for Liquid Crystal Display Backlights (2021)

We discuss the performance of GE's new green phosphors for wide color gamut in liquid crystal displays. These new phosphors are combined with GE's K 2 SiF 6 :Mn 4+ (KSF/PFS) red phosphor to increase color gamut by &gt;5% versus standard KSF/β‐SiAlON:Eu 2+ phosphor blends. Other phosphor performance metrics such as response time, thermal quenching, and environmental stability will also be discussed.
Triglyceride-Glucose Index Predicts Future Atherosclerotic Cardiovascular Diseases: A 16-Year Follow-up in a Prospective, Community-Dwelling Cohort Study (2023)

The TyG index is independently associated with future CVDs in 16 years of follow-up in large, prospective Korean cohort.
Temperature-responsive copolymers without compositional drift by RAFT copolymerization of 2-(acryloyloxy)ethyl trimethylammonium chloride and 2-(diethylamino)ethyl acrylate (2019)

Thermoresponsive copolymers based on AEtMACl and protonated DEAEA feature RAFT copolymerization kinetics with both apparent reactivity ratios of about 1.
SPORT EQUIPMENT - ENERGY AND PERFORMANCE (2007)

Over the past 30 years, sport scientists and sport equipment manufacturers have investigated ways of improving athletic equipment to enhance performance. The result is equipment that is stronger, lighter, more durable and more pleasant to use. Consequently, sport performances are faster, higher, longer and more accurate than they used to be. In fact every world record in sport which was set before 1980 has been broken an indication for the recent developments in athletic ability and improvements in athletic equipment.
Cell invasion in digital microfluidic microgel systems (2020)

Microfluidic methods for studying cell invasion can be subdivided into those in which cells invade into free space and those in which cells invade into hydrogels. The former techniques allow straightforward extraction of subpopulations of cells for RNA sequencing, while the latter preserve key aspects of cell interactions with the extracellular matrix (ECM). Here, we introduce "cell invasion in digital microfluidic microgel systems" (CIMMS), which bridges the gap between them, allowing the stratification of cells on the basis of their invasiveness into hydrogels for RNA sequencing. In initial studies with a breast cancer model, 244 genes were found to be differentially expressed between invading and noninvading cells, including genes correlating with ECM-remodeling, chemokine/cytokine receptors, and G protein transducers. These results suggest that CIMMS will be a valuable tool for probing metastasis as well as the many physiological processes that rely on invasion, such as tissue development, repair, and protection.
Human primary motor cortex indexes the onset of subjective intention in brain-machine-interface mediated actions (2023)

Self-initiated behavior is accompanied by the experience of willing our actions. Here, we leverage the unique opportunity to examine the full intentional chain - from will (W) to action (A) to environmental effects (E) - in a tetraplegic person fitted with a primary motor cortex (M1) brain machine interface (BMI) generating hand movements via neuromuscular electrical stimulation (NMES). This combined BMI-NMES approach allowed us to selectively manipulate each element of the intentional chain (W, A, and E) while performing extra-cellular recordings and probing subjective experience. Our results reveal single-cell, multi-unit, and population-level dynamics in human M1 that encode W and may predict its subjective onset. Further, we show that the proficiency of a neural decoder in M1 reflects the degree of W-A binding, tracking the participant's subjective experience of intention in (near) real time. These results point to M1 as a critical node in forming the subjective experience of intention and demonstrate the relevance of intention-related signals for translational neuroprosthetics.
Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance (2016)

B cells are unique antigen-presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4<sup>+</sup> T cell-negative selection. However, the nature of thymocyte-thymic B cell interaction and how this interaction affects the selection of thymic B cell repertoire and, in turn, the T cell repertoire are not well understood. Here we demonstrate that a large percentage of thymic B cells have undergone class switching intrathymically. Thymic B cell class switching requires cognate interaction with specific T cells. Class-switched thymic B cells have a distinct repertoire compared with unswitched thymic B cells or splenic B cells. Particularly, autoreactive B cell specificities preferentially expand in the thymus by undergoing class switching, and these enriched, class-switched autoreactive thymic B cells play an important role in CD4 T cell tolerance.
ChemInform Abstract: Transformation of Alkyl N‐(Vinyloxy)benzimidates (I)‐(III) to Alkyloxazoles. Mechanism and Extension. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Operational Mesogamma-Scale Analysis and Forecast System of the U.S. Army Test and Evaluation Command. Part IV: The White Sands Missile Range Auto-Nowcast System (2008)

Abstract During the summer months at the U.S. Army Test and Evaluation Command’s (ATEC) White Sands Missile Range (WSMR), forecasting thunderstorm activity is one of the primary duties of the range forecasters. The safety of personnel working on the range and the protection of expensive test equipment depend critically on the quality of forecasts of thunderstorms and associated hazards, including cloud-to-ground lightning, hail, strong winds, heavy rainfall, flash flooding, and tornadoes. The National Center for Atmospheric Research (NCAR) Auto-Nowcast (ANC) system is one of the key forecast tools in the ATEC Four-Dimensional Weather System (4DWX) at WSMR, where its purpose is to aid WSMR meteorologists in their mission of very short term thunderstorm forecasting. Besides monitoring the weather activity throughout the region and warning personnel of potentially hazardous thunderstorms, forecasters play a key role in assisting with the day-to-day planning of test operations on the range by providing guidance with regard to weather conditions favorable to testing. Moreover, based on climatological information about the local weather conditions, forecasters advise their range customers about scheduling tests at WSMR months in advance. This paper reviews the NCAR ANC system, provides examples of the ANC system’s use in thunderstorm forecasting, and describes climatological analyses of WSMR summertime thunderstorm activity relevant for long-range planning of tests. The climatological analysis illustrates that radar-detected convective cells with reflectivity of ≥35 dBZ at WSMR are 1) short lived, with 76% having lifetimes of less than 30 min; 2) small, with 67% occupying areas of less than 25 km2; 3) slow moving, with 79% exhibiting speeds of less than 4 m s−1; 4) moderately intense, with 80% showing reflectivities in excess of 40 dBZ; and 5) deep, with 80% of the storms reaching far enough above the freezing level to be capable of generating lightning.
High‐Throughput Screening Assays for the Assessment of Cytotoxicity (2013)

The assessment of cellular health and viability after new chemical entity exposure is a near obligate activity for drug discovery efforts because it conveniently addresses potential on- and off-target toxicities early in the screening process. This chapter addresses a number of basic considerations for employing high-throughput cytotoxicity chemistries and achieving screening success. Elements such as cell model, control toxins, and choice of cytotoxic measures are addressed. The relative merits and detractions of single parameter assay formats will be discussed with regard to sensitivity, ease-of-use, robustness, and false hit rate. Lastly, new multi-parametric formats will be introduced which can identify mechanism of action and provide additional per-well data points useful for normalization or interference identification.
Expression of human recombinant β2‐glycoprotein I with anticardiolipin antibody cofactor activity (1993)

To enable the synthesis of beta 2-glycoprotein I mutants we have established a stable Chinese hamster ovary cell line that expresses human beta 2-glycoprotein I up to 2.9 micrograms/10(6) cells/day. Recombinant beta 2-glycoprotein I is identical to the purified native protein with respect to cofactor activity revealed in a modified anti-cardiolipin ELISA. Autoimmune type anti-cardiolipin antibody requires recombinant beta 2-glycoprotein I in a dose-dependent manner to bind cardiolipin whilst binding of infectious type antibody is inhibited. The purified recombinant beta 2-glycoprotein I in serum free medium exists as two oligosaccharide species which upon deglycosylation have identical apparent molecular weight to the deglycosylated native protein.
Fünf-Jahres-Follow-up von Extremfrühgeborenen nach zeitgerechten oder verspäteten ersten Routineimpfungen (2023)

Hintergrund Infektionen gehören zu den häufigen Komplikationen bei Frühgeborenen mit einem Gestationsalter unter 29 Wochen (extermely-low-gestational-age neonates, ELGANs). Auch nach Entlassung aus dem primären stationären Aufenthalt kennzeichnet die Kinder eine erhöhte Vulnerabilität, insbesondere gegenüber infektiösen Atemwegserkrankungen. Impfungen gelten als effektive und sichere Präventionsmaßnahme. Neben dem Schutz vor impfpräventablen Krankheiten werden unspezifisch trainierende Effekte auf das Immunsystem diskutiert. Dennoch werden Frühgeborene häufig nicht oder verspätet geimpft. Gründe hierfür und Konsequenzen für die Kinder sind bisher unzureichend untersucht.
Structural and Energetic Analysis of Metal Ions Essential to SRP Signal Recognition Domain Assembly (2002)

The signal recognition particle (SRP) targets proteins to the endoplasmic reticulum in eukaryotes or to the inner membrane in prokaryotes by binding to hydrophobic signal sequences. Signal peptide recognition occurs within the highly conserved RNA-protein core of the SRP, underscoring the importance of this complex in SRP function. Structural analysis of the RNA and protein components of the prokaryotic SRP in the free and bound states revealed that the RNA undergoes a significant conformational change upon protein binding involving the uptake of several monovalent and divalent cations. To investigate the role of these metal ions in formation of the functional SRP complex, we used binding affinity assays and X-ray crystallography to analyze the specificity and energetic contributions of mono- and divalent metal ions bound in the RNA. Our results demonstrate that several metal ion binding sites important for RNA conformation can accommodate chemically distinct ions, often without affecting the structure of the complex. Thus, while these metal ions are highly ordered and essential for the formation and stability of the SRP complex, they behave like nonspecific metal ions.
POLYARTERITIS NODOSA PRESENTING AS HEMATURIA AND A TESTICULAR MASS (2001)

No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 Aug 2001POLYARTERITIS NODOSA PRESENTING AS HEMATURIA AND A TESTICULAR MASS KARYN S. EILBER, STEPHEN J. FREEDLAND, and JACOB RAJFER KARYN S. EILBERKARYN S. EILBER , STEPHEN J. FREEDLANDSTEPHEN J. FREEDLAND , and JACOB RAJFERJACOB RAJFER View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66008-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "POLYARTERITIS NODOSA PRESENTING AS HEMATURIA AND A TESTICULAR MASS." The Journal of Urology, 166(2), p. 624 References 1 : Polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Clinical aspects and treatment. Rheum Dis Clin North Am1995; 21: 911. Google Scholar 2 : Testicular lesions of periarteritis nodosa, with special reference to diagnosis. Am J Med1960; 28: 222. Google Scholar 3 : Polyarteritis nodosa masquerading as a primary testicular neoplasm: a case report and review of the literature. J Urol1990; 144: 1236. Link, Google Scholar From the Department of Urology, University of California Los Angeles, Los Angeles, California© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 166Issue 2August 2001Page: 624 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsabnormalitiespolyarteritis nodosahematuriaMetricsAuthor Information KARYN S. EILBER More articles by this author STEPHEN J. FREEDLAND More articles by this author JACOB RAJFER Financial interest and/or other relationship with Pfizer and Bayer. More articles by this author Expand All Advertisement PDF downloadLoading ...
Gravitationally driven deterministic lateral displacement devices (2009)

Deterministic lateral displacement (DLD) is a powerful bimodal separation scheme [1] based on regular obstacle arrays that in its basic embodiment sends particles in two different directions as a function of size. We add functionality to the technique by including gravitational forces, as a perturbation to particles transported by fluid flow, and as a way of transporting the particles through a stationary fluid.