gebhart/patrepeval huggingface dataset:
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 (2011)

Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Replication of the top hits was attempted with data from 10 additional replication datasets. Results With a cumulative sample size of 6709 cases and 44 439 controls, one genome-wide significant locus was identified on chromosome 7q22 for knee OA (rs4730250, p=9.2×10 −9 ), thereby confirming its role as a susceptibility locus for OA. Conclusion The associated signal is located within a large (500 kb) linkage disequilibrium block that contains six genes: PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, β), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5 ), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like) and BCAP29 (B cell receptor-associated protein 29). Gene expression analyses of the (six) genes in primary cells derived from different joint tissues confirmed expression of all the genes in the joint environment.
Applications of Scanning Near-Field Photon Emission Microscopy (2008)

Abstract In this paper, the application of scanning near-field photon emission microscopy for imaging photon emission sites is demonstrated. Photon emissions generated by a Fin-FET test structure with one metallization layer are imaged with spatial resolution of 50 nm using scattering dialectic probe. The potential applications and limitations of the technique are discussed.
Testing and Results of Vacuum Swing Adsorption Units for Spacesuit Carbon Dioxide and Humidity Control (2011)

A principal concern for extravehicular activity (EVA) spacesuits is the capability to control carbon dioxide (CO2) and humidity (H2O) for the crewmember. The release of CO2 in a confined or unventilated area is dangerous for human health and leads to asphyxiation; therefore, CO2 and H2O control become leading factors in the design and development of the spacesuit. An amine-based CO2 and H2O vapor sorbent for use in pressure-swing regenerable beds has been developed by Hamilton Sundstrand. The application of solidamine materials with vacuum swing adsorption technology has shown the capacity to concurrently manage CO2 and H2O levels through a fully regenerative cycle eliminating mission constraints imposed with nonregenerative technologies. Two prototype solid amine-based systems, known as rapid cycle amine (RCA), were designed to continuously remove CO2 and H2O vapor from a flowing ventilation stream through the use of a two-bed amine based, vacuum-swing adsorption system. The Engineering and Science Contract Group (ESCG) RCA implements radial flow paths, whereas the Hamilton Sundstrand RCA was designed with linear flow paths. Testing was performed in a sea-level pressure environment and a reduced-pressure environment with simulated human metabolic loads in a closed-loop configuration. This paper presents the experimental results of laboratory testing for a full-size and a sub-scale test article. The testing described here characterized and evaluated the performance of each RCA unit at the required Portable Life Support Subsystem (PLSS) operating conditions. The test points simulated a range of crewmember metabolic rates. The experimental results demonstrated the ability of each RCA unit to sufficiently remove CO2 and H2O from a closed loop ambient or sub-ambient atmosphere.
Rapid temporal scanning of ultrafast lasers (1997)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Sucha, M. E. Fermann, D. J. Harter, and M. Hofer, "Rapid temporal scanning of ultrafast lasers," in Ultrafast Electronics and Optoelectronics, M. Nuss and J. Bowers, eds., Vol. 13 of OSA Trends in Optics and Photonics Series (Optica Publishing Group, 1997), paper UE5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Creating a power-aware structured ASIC (2004)

In an attempt to enable the cost-effective production of low-and mid-volume application-specific chips, researchers have proposed a number of so-called structured ASIC architectures. These architectures represent a departure from traditional standard-cell-based ASIC designs in favor of techniques which present more physical and structural regularity. This paper presents circuits which provide power-performance exibility in this regular, structured ASIC environment. These circuits, which employ gate sizing and voltage scaling for energy efficiency, enable delay-constrained power optimization to be performed for structured ASIC designs.
Tracking of Scalpel Motions With an Inertial Measurement Unit System (2022)

Surgical planning to visualize a complete procedure before surgical intervention, paired with the advanced surgical techniques of a surgeon, has been shown to improve surgical outcomes. Efforts to improve surgical planning have included tracking real-time surgeon movements via surgical instruments in a confined body cavity space in the human body to enhance specific techniques when performing minimally invasive surgery. In this work, a surgical tool tracking approach is presented that leverages small scale electronics to enable real-time position capture for use in iterative surgical planning. By integrating a lightweight 9 degree-of-freedom Inertial Measurement Unit (IMU), our system captures both spatial and temporal information of the surgical tool without requiring a direct line-of-sight. The IMU is printed on a flexible film and attached to and integrated with a surgical tool demonstrating its tracking capabilities. Data from the IMU is analyzed to determine the full range of motion during angular displacement for measurement and tracking. The results show an accuracy of 2.2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> , 2.9 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> and 3.1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> of the full range of motion of the X (Yaw), Y (Roll) and Z (Pitch) Euler angle coordinate system respectively demonstrating the potential for surgical tool tracking measurement without the need for a direct line of sight and with future impact including flexible electronics and motion tracking. This work will be helpful in a diversity of fields including surgery, surgical training, biomaterials, and motion tracking.
Concurrent programming in the Ada® language: The polling bias (1984)

Abstract The rendezvous is an important concept in concurrent programming—two processes need to synchronize, i.e. rendezvous, to exchange information. The Ada programming language is the first programming language to use the rendezvous as the basis of its concurrent programming facilities. Our experience with rendezvous facilities in the Ada language shows that these facilities lead to and encourage the design of programs that poll. Polling is generally, but not always, undesirable because it is wasteful of system resources. We illustrate and examine the reasons for polling bias in the Ada language. We give suggestions on how to avoid polling programs, and suggest changes to the rendezvous facilities to eliminate the polling bias. The ramifications of these changes to the implementation of the Ada language are also discussed. Although we have focused on the rendezvous facilities in the Ada language our analysis is also applicable to other languages. A polling bias can occur in any concurrent programming language based on the rendezvous mechanism if it does not provide appropriate facilities.
Total Synthesis and Biological Evaluation of Heliolactone (2019)

Abstract Strigolactones are phytohormones, which affect diverse aspects of plant growth and development with potential application in modern agriculture. Recently, heliolactone has been isolated as a non‐canonical type of strigolactone from the root exudates of sunflower, and it could be involved in signaling in the rhizosphere as well as in planta . However, its biological activity is yet to be evaluated, due to its relative chemical instability and its low natural abundance. Herein, we describe the gram‐scale synthesis of heliolactone and its derivatives by using Stille cross‐coupling as the key bond‐forming reaction, and we disclose some of their biological activities (soil stability, binding ability to strigolactone receptor, corn germination, sunflower germination, Orobanche cumana germination and leaf senescence) in comparison with other canonical and non‐canonical strigolactones.
Expression of adipocyte/macrophage fatty acid binding protein in tumor associated macrophage promotes breast/mammary tumor progression (2017)

Abstract Tumor associated macrophages (TAMs) play a critical role in cancer development and progression. However, due to the heterogeneity of TAMs, it remains a major challenge to identify clinically-relevant markers for pro-tumor TAMs. Here, we report that expression of adipocyte/macrophage fatty acid binding protein (A-FABP) in TAMs promotes breast cancer progression. While upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, we demonstrated that the pro-tumor effect of A-FABP was mediated by TAMs. More specifically, A-FABP was preferentially upregulated in a subset of TAMs that exhibited a CD11b+F4/80+MHCII−Ly6C− phenotype, which promoted tumor progression through IL-6/STAT3 pathway. Mechanistically, activated NFκB in A-FABP+ TAMs repressed the expression of miR-29b, resulting in enhanced tumor-promoting IL-6 signaling as compared to A-FABP −/− TAMs. Thus, A-FABP represents as a new functional marker for pro-tumor TAMs and a new target for macrophage-based tumor immunotherapy.
Small Sequence‐Sensitive Compounds for Specific Recognition of the G⋅C Base Pair in DNA Minor Groove (2019)

A series of small diamidines with thiophene and modified N-alkylbenzimidazole σ-hole module represent specific binding to single G⋅C base pair (bp) DNA sequence. The variation of N-alkyl or aromatic rings were sensitive to microstructures of the DNA minor groove. Thirteen new compounds were synthesized to test their binding affinity and selectivity. The dicyanobenzimidazoles needed to synthesize the target diamidines were made via condensation/cyclization reactions of different aldehydes with different 3-amino-4-(alkyl- or phenyl-amino) benzonitriles. The final diamidines were synthesized using lithium bis-trimethylsilylamide (LiN[Si(CH<sub>3</sub> )<sub>3</sub> ]<sub>2</sub> ) or Pinner methods. The newly synthesized compounds showed strong binding and selectivity to AAAGTTT compared to similar sequences AAATTT and AAAGCTTT investigated by several biophysical methods including biosensor-SPR, fluorescence spectroscopy, DNA thermal melting, ESI-MS spectrometry, circular dichroism, and molecular dynamics. The binding affinity results determined by fluorescence spectroscopy are in accordance with those obtained by biosensor-SPR. These small size single G⋅C bp highly specific binders extend the compound database for future biological applications.
Effect of Depolymerized Holothurian Glycosaminoglycan (DHG) on the Activation of Factor VIII and Factor V by Thrombin (1996)

Our previous study has shown that depolymerized holothurian glycosaminoglycan (DHG) has two different inhibitory activities in the blood coagulation cascade: heparin cofactor II-dependent thrombin inhibition; and antithrombin III- and heparin cofactor II-independent inhibition of the intrinsic factor Xase complex [Nagase et al. (1995) Blood 85, 1527-1534]. In the present study, the effect of DHG on the activation of factor VIII and factor V by thrombin was examined with purified human components. DHG inhibited the activation of factor VIII by thrombin at concentrations exceeding 80 nM, but not the activation of factor V by thrombin at concentrations of up to 8 mu M. On Western blot analysis, DHG inhibited the cleavage of factor VIII light chain at concentrations exceeding 0.8 mu M. The interaction between DHG and factors VIII and V and thrombin was examined with a DHG-cellulofine column. DHG had strong affinity for factor V and thrombin, but slight affinity for factor VIII. The interaction of DHG with thrombin was analyzed, using fluorescein isothiocyanate-labeled DHG. One mole of DHG bound 2 mol of thrombin, with a dissociation constant (Kd) of 3.04 x 10(-6) M. These results suggest that DHG interferes with the interaction between thrombin and factor VIII, probably by making a binary complex through the anionic binding exosite II of thrombin.
Long-term cardiac abnormalities after cranial radiotherapy in childhood cancer survivors (2014)

Cranial RT in CCS is associated with smaller cardiac volumes and reduced systolic and diastolic LV function. This off target effect of RT might be related to lower insulin-like growth factor levels.
Efficient One-Pot Synthesis of 2‘-Deoxyribonucleoside 3‘-O- and 5‘-O-Phosphorodithioates (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEfficient One-Pot Synthesis of 2'-Deoxyribonucleoside 3'-O- and 5'-O-PhosphorodithioatesAndrzej Okruszek, Magdalena Olesiak, Danuta Krajewska, and Wojciech J. StecView Author Information Polish Academy of Sciences, Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363 Łódź, Poland Cite this: J. Org. Chem. 1997, 62, 7, 2269–2272Publication Date (Web):April 4, 1997Publication History Received20 September 1996Published online4 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/jo961801ghttps://doi.org/10.1021/jo961801gbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views283Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ammonia,Biopolymers,Nucleic acids,Reaction products,Sulfur Get e-Alerts
Beamwidth measurement of individual lithotripter shock waves (2009)

New lithotripters with narrower foci and higher peak pressures than the original Dornier HM3 electrohydraulic lithotripter have proven to be less effective and less safe. Hence, accurate measurements of the focal characteristics of lithotripter shock waves are important. The current technique for measuring beamwidth requires a collection of single-point measurements over multiple shock waves, thereby introducing error as a result of any shock-to-shock variability. This work reports on the construction of a hydrophone array sensor and on array measurements of individual lithotripter shock waves. Beamwidths for an electrohydraulic lithotripter with a broad-focus HM3-style reflector and a narrow-focus modified reflector were measured using both new and worn electrodes as well as two different electrical charging potentials. The array measured the waveform, beamwidth, and focal location of individual shock waves. The HM3-style reflector produced repeatable focal waveforms and beam profiles at an 18 kV charging potential with new and worn electrodes. Corresponding measurements suggest a narrower beamwidth than reported previously from averaged point measurements acquired under the same conditions. In addition, a lack of consistency in the measured beam profiles at 23 kV underscores the value of measuring individual shock waves.
High‐Modulus Spin‐On Organosilicate Glasses for Nanoporous Applications (2007)

Both the modulus and hardness of a conventional methylsilsesquioxane-type organosilicate, typically synthesized from the methyltrimethoxysilane monomer, can be substantially improved by incorporating organic bridging units through additions of the bis(triethoxysilyl)ethane monomer. The microstructural basis for these enhanced properties is described in this Communication. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1528_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Short Time to Progression under First-Line Chemotherapy Is a Negative Prognostic Factor for Time to Progression and Residual Survival under Second-Line Chemotherapy in Advanced Pancreatic Cancer (2007)

In our cohort of patients with advanced pancreatic cancer treated with second-line chemotherapy, TTP1 <6 months is a strong negative prognostic factor for TTP2 and residual survival.
Generation of pulsed squeezed light at telecommunication wavelength using a high efficiency PPLN optical waveguide (2011)

In the present work, we report the generation of pulsed squeezed light at 1550 nm by parametric amplification in a low-optical-loss high-efficiency PPLN-WG of length 51 mm developed by NIMS/Waseda. We observed -1.7 dB of squeezing and +6.5 dB of anti-squeezing when the pump pulse energy was only 3nJ (peak power was 0.5 W). The results indicate that the waveguide is capable of generating more than 6 dB squeezing by improving optical losses by shortening the WG length, anti-reflecting coating on WG surfaces, and temporal shaping of the local oscillator, and more that 10 dB squeezing may be possible by using the state of-the-art high efficiency photodiodes.
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination (2022)

Both 1.0 mg and 2.0 mg doses of Staccato alprazolam demonstrated efficacy in rapidly terminating seizures in an inpatient setting and were well tolerated. The next step is a Phase 3 confirmatory study to demonstrate efficacy and safety of Staccato alprazolam for rapid cessation of seizures in an outpatient setting.
Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT (2007)

We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 x 1000 x 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMD-related drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.
Attention, memory, and wearable interfaces (2002)

The paper considers the limits of human attention and how wearable interfaces should be developed to complement, not interfere, with normal human capabilities. Most interfaces on desktop computers do not have this problem; desktop interface designers can assume that the user is solely concentrating on the digital task. However, a major advantage of a wearable is that users can take it anywhere and use it anytime.
ChemInform Abstract: The Synthesis of 2,3,3a,4,5,7a‐Hexahydro‐1H‐inden‐1‐ols by Intramolecular Diels‐Alder Reactions of 1,3,8‐Nonatrien‐5‐ols. Dependence of Product Stereochemistry on the Substitution Pattern. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Predictive yield modeling for reconfigurable memory circuits (2002)

This paper presents a novel approach to the modeling of defect related yield losses in reconfigurable memory circuits. The proposed approach is based on the critical area extracted from the memory layout and the in-line defect inspection data. A complete chip level yield model that takes into account the actual redundancy scheme is presented, with the demonstration of excellent accuracy between the model prediction and bitmap data from an actual flash memory product manufactured by Intel Corporation.
Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation (2015)

Intrinsically disordered proteins/regions (IDPs/IDRs) are proteins or peptide segments that fail to form stable 3-dimensional structures in the absence of partner proteins. They are abundant in eukaryotic proteomes and are often associated with human diseases, but their biological functions have been elusive to study. In this study, we report the identification of a tin(IV) oxochloride-derived cluster that binds an evolutionarily conserved IDR within the metazoan TFIID transcription complex. Binding arrests an isomerization of promoter-bound TFIID that is required for the engagement of Pol II during the first (de novo) round of transcription initiation. However, the specific chemical probe does not affect reinitiation, which requires the re-entry of Pol II, thus, mechanistically distinguishing these two modes of transcription initiation. This work also suggests a new avenue for targeting the elusive IDRs by harnessing certain features of metal-based complexes for mechanistic studies, and for the development of novel pharmaceutical interventions.