gebhart/patrepeval huggingface dataset:
Robust Timing Attack Countermeasure on Virtual Hardware (2018)

Field programmable gate arrays (FPGAs) are being increasingly used in Internet of Things (IoT) applications, as they usually provide lower power, lower latency and higher performance compared with their processor counterparts. However, security has emerged as a critical concern for FPGA-based systems as they are vulnerable to different form of physical attacks, such as side-channel attacks (SCAs). Existing protection methods, which primarily rely on bitstream encryption, are computationally expensive and more importantly, cannot protect against run-time attacks. Hardware virtualization, where instead of traditional direct mapping to FPGA, an application is mapped upon an application-specific virtual layer, called overlay, has been well-studied in past decades for productivity benefit, while its security implication has not been investigated at all. In this paper, for the first time to our knowledge, we present a novel usage of virtualization that limits damage from timing attacks and improves performance for RSA decryption by employing unique reconfigurable hardware architectures on FPGAs. Specific masking methods are implemented onto this architecture, and extensive security and performance analysis are done that demonstrates significant side-channel attack resistance under performance constraint.
Nucleophilic ethynyl group equivalent and its use in conjugate addition to .alpha.,.beta.-enones (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleophilic ethynyl group equivalent and its use in conjugate addition to .alpha.,.beta.-enonesE. J. Corey and Robert H. WollenbergCite this: J. Am. Chem. Soc. 1974, 96, 17, 5581–5583Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ja00824a052https://doi.org/10.1021/ja00824a052research-articleACS PublicationsRequest reuse permissionsArticle Views647Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Progress towards low cost Tbps optical engines (2015)

A low cost Tb/s class CWDM optical engine prototype based on four different wavelength VCSELs around 1um is presented. 100Gbps operation per fiber is demonstrated.
Abstract 106: A requirement for FADD and its phosphorylation for KRAS-driven oncogenesis (2014)

Abstract Lung cancer accounts for 27% of all cancer deaths worldwide. 80% of these deaths are due to a specific subtype Non-small cell lung cancer (NSCLC). Almost half of all NSCLC patients carry gatekeeper mutations in the EGFR/KRAS pathway. Although KRAS mutations are the most prevalent mutations in human cancers, therapies targeting KRAS have fallen short. Tyrosine kinase inhibitors have been successful in NSCLC patients with mutant or amplified EGFR, however resistance to these inhibitors is common. Thus therapies targeting mutant KRAS or its downstream effectors are desperately needed for the treatment of NSCLC. FAS Associated Death Domain (FADD) is a well characterized adaptor protein involved in death receptor mediated apoptosis, but more recently has been implicated in the regulation of other cellular functions such as cell cycle and proliferation. Increasing evidence suggests that it is FADD's phosphorylated state which regulates these non-apoptotic signaling pathways. We and others have previously identified phosphorylated FADD as a predictor of aggressiveness and clinical stage in lung and head and neck cancer patients, respectively. Using non-invasive bioluminescence and µCT imaging in a Kras driven mouse model of NSCLC, we demonstrate the requirement for FADD in tumor progression. Lung-specific activation of KrasG12D and simultaneous FADD deletion resulted in reduced lung tumor burden. Furthermore lung lesions of KrasG12D FADD null mice were significantly smaller with a decrease in proliferative index. Similar findings were obtained in MEFs, where siRNA mediated Kras knockdown or the use of MEK inhibitors resulted in a Kras dependent decrease in FADD phosphorylation, decrease in cell cycle progression and cell proliferation. These data propound the phosphorylation of FADD as a downstream event of Kras signaling and demonstrate its requirement for Kras dependent neoplasia in a mouse model for NSCLC. In summary our findings demonstrate that elevated FADD and phosphorylated FADD levels are predictive of poor survival in an animal model of NSCLC agreeing with clinical findings. Furthermore, it implicates phosphorylation of FADD downstream of KRAS activation and thus suggests FADD phosphorylation as a valid target in the treatment of NSCLC patients. Citation Format: Brittany M. Bowman, Stefanie Galban, Benjamin A. Hoff, Kevin A. Heist, Jennifer L. Boes, Craig J. Galban, Rajiv M. Patel, Jianke Zhang, Brian D. Ross, Alnawaz Rehemtulla. A requirement for FADD and its phosphorylation for KRAS-driven oncogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 106. doi:10.1158/1538-7445.AM2014-106
Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror (2012)

By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have to sacrifice either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning OR-PAM by using a water-immersible microelectromechanical systems (MEMS) scanning mirror (MEMS-OR-PAM). In MEMS-OR-PAM, the optical and acoustic beams are confocally configured and simultaneously steered, which ensures the uniform detection sensitivity. A B-scan imaging speed as high as 400 Hz can be achieved over a 3 mm scanning range. Using the system, we imaged the flow dynamics of both red blood cells and carbon particles in a mouse ear in vivo. Presented results show that MEMS-OR-PAM could be a powerful tool for studying highly dynamic and time-sensitive biological phenomena.
Set of Modulation and Coding based on RGMI in Nonlinear Fiber Transmissions (2016)

We compare various modulation formats and variable-rate LDPC codes based on required GMI in nonlinear fiber transmissions. Pareto-ecient pairs of modulation and coding are identified to achieve both higher spectral eciency and higher non inearity tolerance.
The human brain: the final journey (2008)

OPINION article Front. Neurosci., 01 August 2008 | https://doi.org/10.3389/neuro.01.020.2008
Throughput Analysis and User Barring Design for Uplink NOMA-Enabled Random Access (2021)

Being able to accommodate multiple simultaneous transmissions on a single channel, non-orthogonal multiple access (NOMA) appears as an attractive solution to support massive machine type communication (mMTC) that faces a massive number of devices competing to access the limited number of shared radio resources. In this paper, we first analytically study the throughput performance of NOMA-based random access (RA), namely NOMA-RA. We show that while increasing the number of power levels in NOMA-RA leads to a further gain in maximum throughput, the growth of throughput gain is slower than linear. This is due to the higher-power dominance characteristic in power-domain NOMA known in the literature. We explicitly quantify the throughput gain for the very first time in this paper. With our analytical model, we verify the performance advantage of NOMA-RA scheme by comparing with the baseline multi-channel slotted ALOHA (MS-ALOHA), with and without capture effect. Despite the higher-power dominance effect, the maximum throughput of NOMA-RA with four power levels achieves over three times that of the MS-ALOHA. However, our analytical results also reveal the sensitivity of load on the throughput of NOMA-RA. To cope with the potential bursty traffic in mMTC scenarios, we propose adaptive load regulation through a practical user barring algorithm. By estimating the current load based on the observable channel feedback, the algorithm adaptively controls user access to maintain the optimal loading of channels to achieve maximum throughput. When the proposed user barring algorithm is applied, simulations demonstrate that the instantaneous throughput of NOMA-RA always remains close to the maximum throughput confirming the effectiveness of our load regulation.
Pseudorotation in arylbis(4,4'-dimethyl-2,2'-biphenylylene)phosphoranes (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPseudorotation in arylbis(4,4'-dimethyl-2,2'-biphenylylene)phosphoranesGeorge M. Whitesides, Michael Eisenhut, and William M. BuntingCite this: J. Am. Chem. Soc. 1974, 96, 17, 5398–5407Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ja00824a014https://doi.org/10.1021/ja00824a014research-articleACS PublicationsRequest reuse permissionsArticle Views1020Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
<title>Adaptive ladar receiver for multispectral imaging</title> (2001)

We are developing a novel 2D focal plane array (FPA) with read-out integrated circuit (ROIC) on a single chip for 3D laser radar imaging. The ladar will provide high-resolution range and range-resolved intensity images for detection and identification of difficult targets. The initial full imaging-camera-on-a-chip system will be a 64 by 64 element, 100-micrometers pixel-size detector array that is directly bump bonded to a low-noise 64 by 64 array silicon CMOS-based ROIC. The architecture is scalable to 256 by 256 or higher arrays depending on the system application. The system will provide all the required electronic processing at pixel level and the smart FPA enables directly producing the 3D or 4D format data to be captured with a single laser pulse. The detector arrays are made of uncooled InGaAs PIN device for SWIR imaging at 1.5 micrometers wavelength and cooled HgCdTe PIN device for MWIR imaging at 3.8 micrometers wavelength. We are also investigating concepts using multi-color detector arrays for simultaneous imaging at multiple wavelengths that would provide additional spectral dimension capability for enhanced detection and identification of deep-hide targets. The system is suited for flash ladar imaging, for combat identification of ground targets from airborne platforms, flash-ladar imaging seekers, and autonomous robotic/automotive vehicle navigation and collision avoidance applications.
Assessment of endogenous opioid mediation in stress-induced hypercholesterolemia in the rat. (1988)

Stressful stimuli are known to elevate total plasma cholesterol levels and activate endogenous opioid systems. In cholesterol-cholic, acid-fed female rats, a 5-day unpredictable immobilization stress paradigm increased levels of low plus very low density lipoprotein cholesterol and reduced levels of high density lipoprotein cholesterol. Pretreatment with the opiate antagonist, naltrexone (1.0 mg/kg, sc) prevented the stress-induced changes. Five-day morphine pellet implants (75 mg) duplicated the cholesterol alterations seen in immobilized rats. In addition, plasma triglyceride levels were elevated in morphine pelleted rats, but hepatic and aortic cholesterol levels were unchanged. Unchanged plasma sorbitol dehydrogenase activity and hepatic triglyceride levels indicated that both regimens were not hepatotoxic. These findings support the possible role for endogenous opioid systems in stress-induced hypercholesterolemia.
Data from Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors (2023)

&lt;div&gt;Abstract&lt;p&gt;In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target inhibition with potent cytotoxic activity. However, as subsequent compounds were evaluated, the cytotoxic activity separated from inhibition of LIM kinases. A rapid determination of the cytotoxic mechanism and its molecular target was enabled by integrating data from two robust core technologies. High-content assays and gene expression profiling both indicated an effect on microtubule stability. Although the cytotoxic compounds are still kinase inhibitors, and their structures did not predict tubulin as an obvious target, these results provided the impetus to test their effects on microtubule polymerization directly. Unexpectedly, we confirmed tubulin itself as a molecular target of the cytotoxic kinase inhibitor compounds. This general approach to mechanism of action questions could be extended to larger data sets of quantified phenotypic and gene expression data. [Mol Cancer Ther 2008;7(11):3490–8]&lt;/p&gt;&lt;/div&gt;
Scheduling for Multiuser MIMO Downlink with Linear Processing (2006)

Block diagonalization (BD) combined with coordinated transmitter-receiver processing and scheduling between users is a simple and straightforward linear method to utilize the available spatial degrees of freedom in downlink multi-user multiple-input multiple-output (MIMO) channel for increasing the system throughput. In this paper, an efficient scheduling algorithm is proposed to maximize the downlink spectral efficiency of the BD method for any number of users and antennas at both the transmitter and the receivers. The performance is compared to the spectral efficiency available with several other scheduling algorithms and to the sum-rate capacity. It is shown that the performance of the BD method with the proposed scheduling approaches the sum rate capacity at high signal-to-noise ratio (SNR) as the number of users increases. It is also noticed that due to the inherent noise amplification problem with linear BD method, the maximum spectral efficiency is often achieved by transmitting to less users/beams than the spatial dimensions available, especially, at low SNR region with a high number of transmit antennas and with a low number of users.
“WE CAN DEVISE THE MEANS” (2005)

Abstract This chapter asks how plans to free and arm large numbers of slaves for the Confederacy's defense could square with a commitment to preserving the South's plantation system, unfree black labor, and maintain white supremacy. It compares “Confederate emancipation” with parallel historical situations elsewhere in the world, other occasions in which social and political elites strove to avoid utter ruin by modifying the ways in which they held and exercised power.
Supplementary Tables 1-7 from Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56γ Knockdown (2023)

Supplementary Tables 1-7 from Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56γ Knockdown
Novel amphiphilic network polymers consisting of nonpolar, short primary polymer chains and polar, long crosslink units: Influence of characteristic dangling chains on swelling behavior of resulting amphiphilic gels (2004)

Abstract Novel amphiphilic network polymers consisting of nonpolar, short primary polymer chains and polar, long crosslink units were prepared, and the swelling behavior of resulting amphiphilic gels is discussed by focusing on the influence of characteristic dangling chains; that is, benzyl methacrylate (BzMA) was copolymerized with tricosaethylene glycol dimethacrylate [CH 2 C(CH 3 )CO(OCH 2 CH 2 ) 23 OCOC(CH 3 )CH 2 , PEGDMA‐23] in the presence of lauryl mercaptan as a chain‐transfer agent because BzMA forms nonpolar, short primary polymer chains and PEGDMA‐23 as a crosslinker contains a polar, long poly(oxyethylene) unit. The enhanced incorporation of dangling chains into the network polymer was brought by shortening the primary polymer chain length, and copolymerization with methoxytricosaethylene glycol methacrylate, a mono‐ene counterpart of PEGDMA‐23, enforced the incorporation of flexible dangling poly(oxyethylene) chains into the network polymer, although the former dangling chains as terminal parts of primary poly(BzMA) chains were rather rigid. Then, the influence of characteristic dangling chains on the swelling behavior of amphiphilic gels was examined in mixed solvents consisting of nonpolar t ‐butylbenzene and polar methanol. The profiles of the solvent‐component dependencies of the swelling ratios were characteristic of amphiphilic gels. The introduction of dangling poly(oxyethylene) chains led not only to an increased swelling ratio but also to sharpened swelling behavior of amphiphilic gels. The swelling response of amphiphilic gels was checked by changing the external solvent polarity. The dangling chains with freely mobile end segments influenced the swelling response of gels. The amphiphilic gels with less entangled, collapsed crosslink units exhibited faster swelling response than the ones with more entangled, collapsed primary polymer chains. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2192–2201, 2004
Adaptive Pair-Matching in the SEARCH Trial and Estimation of the Intervention Effect (2014)

In randomized trials, pair-matching is an intuitive design strategy to protect study validity and to potentially increase study power. In a common design, candidate units are identified, and their baseline characteristics used to create the best n/2 matched pairs. Within the resulting pairs, the intervention is randomized, and the outcomes measured at the end of follow-up. We consider this design to be adaptive, because the construction of the matched pairs depends on the baseline covariates of all candidate units. As consequence, the observed data cannot be considered as n/2 independent, identically distributed (i.i.d.) pairs of units, as current practice assumes. Instead, the observed data consist of n dependent units. This paper explores the consequences of adaptive pair-matching in randomized trials for estimation of the average treatment effect, given the baseline covariates of the n study units. We contrast the unadjusted estimator with targeted minimum loss-based estimation (TMLE) and show substantial efficiency gains from matching and further gains with adjustment. This work is motivated by the Sustainable East Africa Research in Community Health (SEARCH) study, a community randomized trial to evaluate the impact of immediate and streamlined antiretroviral therapy on HIV incidence in rural East Africa.
Atrial Natriuretic Peptide31–67: A Novel Therapeutic Factor for Cardiovascular Diseases (2021)

The characterization of the cardiac hormone atrial natriuretic peptide (ANP<sub>9</sub> <sub>9</sub> <sub>-</sub> <sub>1</sub> <sub>26</sub>), synthesized and secreted predominantly by atrial myocytes under stimulation by mechanical stretch, has established the heart as an endocrine organ with potent natriuretic, diuretic, and vasodilating actions. Three additional distinct polypeptides resulting from proteolytic cleavage of proANP have been identified in the circulation in humans. The mid-sequence proANP fragment 31-67 (also known as proANP<sub>3</sub> <sub>1</sub> <sub>-</sub> <sub>6</sub> <sub>7</sub>) has unique potent and prolonged diuretic and natriuretic properties. In this review, we report the main effects of this circulating hormone in different tissues and organs, and its mechanisms of actions. We further highlight recent evidence on the cardiorenal protective actions of chronic supplementation of synthetic proANP<sub>3</sub> <sub>1</sub> <sub>-</sub> <sub>6</sub> <sub>7</sub> in preclinical models of cardiorenal disease. Finally, we evaluate the use of proANP<sub>3</sub> <sub>1</sub> <sub>-</sub> <sub>6</sub> <sub>7</sub> as a new therapeutic strategy to repair end-organ damage secondary to hypertension, diabetes mellitus, renal diseases, obesity, heart failure, and other morbidities that can lead to impaired cardiac function and structure.
Reactivity-Based Drug Discovery Using Vitamin B6-Derived Pharmacophores (2008)

Endogenous reactive intermediates including photoexcited states of tissue chromophores, reactive oxygen species (ROS), reactive carbonyl species (RCS), transition metal ions, and Schiff bases have been implicated in the initiation and progression of diverse human pathologies including tumorigenesis, atherosclerosis, diabetes, and neurodegenerative disease. In contrast to structure-based approaches that target macromolecules by selective ligands, reactivity-based drug discovery uses chemical reagents as therapeutics that target reactive chemical species involved in human pathology. Reactivity-based design of prototype agents that effectively antagonize, modulate, and potentially even reverse the chemistry underlying tissue damage from oxidative and carbonyl stress therefore holds great promise in delivering significant therapeutic benefit. Apart from its established role as an essential cofactor for numerous enzymes, a large body of evidence suggests that B(6)-vitamers contain reactive pharmacophores that mediate therapeutically useful non-vitamin drug actions as potent antioxidants, metal chelators, carbonyl scavengers, Schiff base forming agents, and photosensitizers. Based on the fascinating chemical versatility of B(6)-derived pharmacophores, B(6)-vitamers are therefore promising lead compounds for reactivity-based drug design.
Simultaneous proton density, T1, T2, and flip‐angle mapping of the brain at 7 T using multiparametric 3D SSFP imaging and parallel‐transmission universal pulses (2020)

These preliminary results show robust proton density, flip angle, T<sub>1</sub> , and T<sub>2</sub> map retrieval. Other parameters, such as ADC, could be assessed. With further optimization in the acquisition, scan time could be reduced and spatial resolution increased to bring this multiparametric quantification method to clinical research routine at 7 T.