gebhart/patrepeval huggingface dataset:
DDR4 transmitter with AC-boost equalization and wide-band voltage regulators for thin-oxide protection in 14-nm SOI CMOS technology (2017)

A DDR4 transmitter (TX) for direct-attach memory on a processor chip is presented as well as the design of the associated low-dropout linear voltage regulators (LDO) that generate the split-mode supply voltages for the thin-oxide protection of the TX output stages operated from the 1.2 V DDR4-supply. The TX uses AC-boost equalization. Signal-integrity (SI) simulations have shown that pre-emphasis equalization is better suited to meet the DRAM eye mask specification than de-emphasis equalization. The LDO design is optimized for good frequency compensation at large load variations, which typically occur during burst-mode transmissions in DDR memory links. A wide-band low-output impedance buffer located between the LDO's error amplifier and the power transistor is proposed that implements a load-sensing and current-injection scheme to extend the low-output impedance range of the buffer, which in turn stabilizes the dominant output pole over a wider di/dt-range. The design is implemented in 14-nm silicon-on-insulator (SOI) CMOS technology, and the key performance measures are 2.8 pJ/b efficiency of the TX when driving with 34 Ω into a 40 Ω DRAM load and a figure-of-merit (FOM) of 96 ps for the LDO.
ProgPrompt: Generating Situated Robot Task Plans using Large Language Models (2022)

Task planning can require defining myriad domain knowledge about the world in which a robot needs to act. To ameliorate that effort, large language models (LLMs) can be used to score potential next actions during task planning, and even generate action sequences directly, given an instruction in natural language with no additional domain information. However, such methods either require enumerating all possible next steps for scoring, or generate free-form text that may contain actions not possible on a given robot in its current context. We present a programmatic LLM prompt structure that enables plan generation functional across situated environments, robot capabilities, and tasks. Our key insight is to prompt the LLM with program-like specifications of the available actions and objects in an environment, as well as with example programs that can be executed. We make concrete recommendations about prompt structure and generation constraints through ablation experiments, demonstrate state of the art success rates in VirtualHome household tasks, and deploy our method on a physical robot arm for tabletop tasks. Website at progprompt.github.io
Chain geometry, solution aggregation and enhanced dichroism in the liquidcrystalline conjugated polymer poly(9,9-dioctylfluorene) (1998)

We report on the physical characterization of a dioctyl-substituted polyfluorene, both in solution and in the solid state. We focus on studies of chain geometry both by molecular modeling and by gel permeation chromatography coupled with light scattering. We determine experimentally a Kuhn segment length, lk = 17.1 ± 2.1 nm and a characteristic ratio C∞ = 21.5 %plusmn; 4.3 indicative of a stiff polymer chain. The effects on absorption and emission spectra of intermolecular interactions that lead to gelation or precipitation from solution are reported. We discuss these results in the context of the strong current interest in the nature of aggregation phenomena and their role in controlling the emissive properties of conjugated polymers. We further show that a markedly enhanced dichroism can be achieved through suitable control of the polymer microstructure.
Stereochemistry of nucleophilic displacement on two phosphoric monoesters and a phosphoguanidine: the role of metaphosphate (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of nucleophilic displacement on two phosphoric monoesters and a phosphoguanidine: the role of metaphosphateStephen L. Buchwald, Jonathan M. Friedman, and Jeremy R. KnowlesCite this: J. Am. Chem. Soc. 1984, 106, 17, 4911–4916Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://doi.org/10.1021/ja00329a047RIGHTS & PERMISSIONSArticle Views449Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (865 KB) Get e-Alerts Get e-Alerts
A data-driven study on the sample size of cellular handoff probe system (2017)

The popularity of big data from cell phone communication records makes cellular handoff probe system become an optimal choice for the collection of traffic speeds, especially for the large-scale freeway network. As a probe-based technique, the issues related to sample size are vital for the accuracy of cellular handoff probe system. Based on the current findings from simulation and field test, this study made an extensive discussion about the sample size problems using the field data. The subsequent investigation began with the correlation analysis between the sample size and the potentially influencing factors (the length of handoff link and traffic volume). Furthermore, a Weibull distribution model was set up to fit sample size for different handoff links. And then, the impact of sample size on the accuracy of cellular handoff probe system was following. Finally, based on the above explorations, several concluding remarks were presented as a reference for determining appropriate sample size to achieve high precision.
Acceleration and scattering of injected electrons in plasma beat wave accelerator experiments* (1994)

The results from experiments in which a two-frequency CO2 laser is used to beat-excite large-amplitude, relativistic electron plasma waves in a tunnel-ionized plasma are reported. The plasma wave is diagnosed by injecting a beam of 2 MeV electrons and observing the energy gain and loss of these electrons, as well as the scattering and deflection of the transmitted electrons near 2 MeV. Accelerated electrons up to 30 MeV have been observed. The lifetime of the accelerating structure as seen by small-angle Thomson scattering is about 100 ps, whereas the injected electrons are seen to be scattered or deflected by the plasma for several ns, with diffuse scattering occurring 0.5–1 ns after forming the plasma wave and whole beam deflection occurring at later times. A simple model, which includes laser focusing, ionization, transit time, and relativistic saturation effects, suggests that the wave coherence may be short lived while the wave fields themselves persist for a longer time. This may be the reason for the disparate time scales between the Thomson scattering and the electron scattering diagnostic. The whole beam deflection may be evidence for a Weibel-like instability at later times.
Ultra-compact multichannel freeform optics for 4xWUXGA OLED microdisplays (2018)

We present an advanced optical design for a high-resolution ultra-compact VR headset for high-end applications based on multichannel freeform optics and 4 OLED WUXGA microdisplays developed under EU project LOMID [1]. Conventional optical systems in VR headsets require large distance between lenses and displays that directly leads to the rather bulky and heavy commercial headsets we have at present. We managed to dramatically decrease the required display size itself and the display to eye distance, making it only 36 mm (to be compared to 60-75 mm in most conventional headsets). This ultra-compact optics allows reducing the headset weight and it occupies about a fourth of volume of a conventional headset with the same FOV. Additionally, our multichannel freeform optics provides an excellent image quality and a large field of view (FOV) leading to highly immersive experience. Unlike conventional microlens arrays, which are also multichannel devices, our design uses freeform optical surfaces to produce, even operating in oblique incidences, the highest optical resolution and Nyquist frequency of the VR pixels where it is needed. The LOMID microdisplays used in our headsets are large-area high-resolution (WUXGA) microdisplays with compact, high bandwidth circuitry, including special measures for high contrast by excellent blacks and low-power consumption. LOMID microdisplay diagonal is 0.98” with 16:10 aspect ratio. With two WUXGA microdisplays per eye, our headset has a total of 4,800x1,920 pixels, i.e. close to 5k. As a result, our multichannel freeform optics provides a VR resolution 24 pixels/deg and a monocular FOV of 92x75 degs (or 100x75 with a binocular superposition of 85%).
Prediction of transmittance spectra for transparent composite electrodes with ultra-thin metal layers (2015)

Recent interest in indium-free transparent composite-electrodes (TCEs) has motivated theoretical and experimental efforts to better understand and enhance their electrical and optical properties. Various tools have been developed to calculate the optical transmittance of multilayer thin-film structures based on the transfer-matrix method. However, the factors that affect the accuracy of these calculations have not been investigated very much. In this study, two sets of TCEs, TiO2/Au/TiO2 and TiO2/Ag/TiO2, were fabricated to study the factors that affect the accuracy of transmittance predictions. We found that the predicted transmittance can deviate significantly from measured transmittance for TCEs that have ultra-thin plasmonic metal layers. The ultrathin metal layer in the TCE is typically discontinuous. When light interacts with the metallic islands in this discontinuous layer, localized surface plasmons are generated. This causes extra light absorption, which then leads to the actual transmittance being lower than the predicted transmittance.
Variational auto-encoding of protein sequences (2017)

Proteins are responsible for the most diverse set of functions in biology. The ability to extract information from protein sequences and to predict the effects of mutations is extremely valuable in many domains of biology and medicine. However the mapping between protein sequence and function is complex and poorly understood. Here we present an embedding of natural protein sequences using a Variational Auto-Encoder and use it to predict how mutations affect protein function. We use this unsupervised approach to cluster natural variants and learn interactions between sets of positions within a protein. This approach generally performs better than baseline methods that consider no interactions within sequences, and in some cases better than the state-of-the-art approaches that use the inverse-Potts model. This generative model can be used to computationally guide exploration of protein sequence space and to better inform rational and automatic protein design.
Mucosal but Not Parenteral Immunization with Purified Human Papillomavirus Type 16 Virus-Like Particles Induces Neutralizing Titers of Antibodies throughout the Estrous Cycle of Mice (1999)

We have recently shown that nasal immunization of anesthetized mice with human papillomavirus type 16 (HPV16) virus-like particles (VLPs) is highly effective at inducing both neutralizing immunoglobulin A (IgA) and IgG in genital secretions, while parenteral immunization induced only neutralizing IgG. Our data also demonstrated that both isotypes are similarly neutralizing according to an in vitro pseudotyped neutralization assay. However, it is known that various amounts of IgA and IgG are produced in genital secretions along the estrous cycle. Therefore, we have investigated how this variation influences the amount of HPV16 neutralizing antibodies induced after immunization with VLPs. We have compared parenteral and nasal protocols of vaccination with daily samplings of genital secretions of mice. Enzyme-linked immunosorbent assay analysis showed that total IgA and IgG inversely varied along the estrous cycle, with the largest amounts of IgA in proestrus-estrus and the largest amount of IgG in diestrus. This resulted in HPV16 neutralizing titers of IgG only being achieved during diestrus upon parenteral immunization. In contrast, nasal vaccination induced neutralizing titers of IgA plus IgG throughout the estrous cycle, as confirmed by in vitro pseudotyped neutralization assays. Our data suggest that mucosal immunization might be more efficient than parenteral immunization at inducing continuous protection of the female genital tract.
Access optimizer to overcome the "future walls of embedded DRAMs" in the era of systems on silicon (2003)

This paper proposes an "access optimizer", a logic attachment for embedded DRAMs, which solves issues in the coming era of systems on silicon. The current embedded DRAM architecture relying on its large number of I/O lines will inherently face new walls. The long first access time causes the bottleneck between an on-chip CPU and an embedded-DRAM macro. The access conflict with the increase of embedded-DRAM masters will significantly degrade the chip performance.
Introduction to the physics of nucleation (2006)

In this introductory article, I review the theory of nucleation by thermal activation and by quantum tunneling. The effect of heterogeneous nucleation at surfaces is discussed and a brief survey of experimental techniques is given.
Long Offset AVO and Anisotropy Calibration Deep Offshore Nigeria (2002)

G-15 LONG OFFSET AVO AND ANISOTROPY CALIBRATION DEEP OFFSHORE NIGERIA Abstract 1 TotalFinaElf drilled an anticlinal prospect in deep water offshore Nigeria. The prospect was mapped using long-offset AVO attributes and included targets spanning more than 1300 m of vertical section. In order to characterize the depth-dependent AVO and anisotropy 72 levellines of 2D walkaway VSP data intermediate VSPs and dipole sonic logs were acquired. This paper focuses on the processing and analysis of this unique and extensive borehole acoustics data set. The geometry of the survey was such that an “AVO walkaway cube” could be constructed providing redundancy of
Coupled-Cavity Traveling-Wave Parametric Amplifiers: Part I-Analysis (1960)

A general class of traveling-wave parametric amplifiers based on coupled-cavity filter circuits is described. This type of amplifier is particularly suited to microwave frequencies and incorporates new features that overcome some severe difficulties associated with other circuit structures. Traveling-wave diode-type amplifiers having relatively wide bandwidths and great simplicity at S band have already resulted from this approach (details of experiments will be described in Part II). An analysis is presented which provides detailed information on operating characteristics, including the effects of terminal impedances, reflected waves, circuit loss, etc., and also leads to a simple physical picture of the cumulative interaction mechanism in terms of coupled-mode concepts. This physical picture is emphasized throughout this paper. Gain bandwidth considerations are discussed in terms of a fundamental "interaction-impedance" parameter. Representative calculated curves show that unilateral gains of 12 to 15 db over relatively wide bandwidths are attainable with as few as 4 to 6 diodes. Methods of increasing the gain through use of ferrites and special circuit techniques are proposed.
The ROI of Metrology (2006)

The conventional premise that metrology is a "non-value-added necessary evil" is a misleading one, which must he viewed as obsolete thinking. Much of the metrology requirements are now key enablers to traditionally labeled "value-added" processing steps in lithography and etch, such that they can be considered integral parts of the processes. This paper will explore the present and future trends and challenges in CD metrology. However, equipment is only part of the battle. The quality application of these tools in a production environment is quite important; the ultimate value-added by metrology is a result of quality tools run by a quality metrology team using quality practices.
Erectile Function Outcome Reporting After Clinically Localized Prostate Cancer Treatment (2007)

Clinical studies reporting erectile function outcomes after localized prostate cancer treatment often demonstrate poorly interpretable and inconsistent manners of assessment as well as widely disparate rates of erectile dysfunction and erectile function. Future studies must apply scientifically rigorous methodology and standard outcomes measures to advance this field of study.
A new 3,4-seco-lupane-type triterpenoid from the pulp ofAcanthopanax senticosus(Rupr. et Maxim) Harms (2010)

A new triterpenoid, 3,4-seco-lupane-20(29)-ene-3,28-dioic acid, together with three known lignans, (-)-schisandrin B, (-)-sesamin and (-)-syringaresinol, was isolated from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Their structures were elucidated by means of physicochemical properties and spectroscopic methods (1D, 2D-NMR and MS).
Modulation of the A3 adenosine receptor by low agonist concentration induces antitumor and myelostimulatory effects (2003)

Abstract The A 3 adenosine receptor (A 3 AR) agonists IB‐MECA and Cl‐IB‐MECA act as anticancer agents by inhibiting the growth of melanoma and colon carcinoma cells both in vitro and in vivo. The A 3 AR is highly expressed in these tumor cells and upon agonist binding receptor internalization and recycling occurs. The downstream signaling pathways that follow these events include a decrease in the expression level of protein kinase A (PKA) and protein kinase B/Akt (PKB/Akt) leading to the deregulation of the Wnt and the NF‐κB signaling pathways. Interestingly, IB‐MECA and Cl‐IB‐MECA generate the opposite, beneficial effect on myeloid cells. These agonists induce the production of granulocyte colony‐stimulating factor (G‐CSF) by murine splenocytes. The molecular mechanisms underlying the events prior to G‐CSF production include the upregulation of NF‐κB and the upstream kinases phosphoinositide 3‐kinase (PI3K), PKB/Akt, and IKK. In addition, a myeloprotective effect is noted upon administration of IB‐MECA and Cl‐IB‐MECA to chemotherapy‐treated mice. This was expressed by accelerated recovery of white blood cells and neutrophil counts in cyclophosphamide‐treated mice following agonist administration. Taken together, activation of the A 3 AR on tumor and normal cells generates opposing responses: in tumor cells, NF‐κB expression level decreases, resulting in tumor growth inhibition, while in normal cells it is upregulated, leading to G‐CSF production and the induction of myelostimulation. It thus appears that A 3 AR agonists act as tumor growth inhibitors, simultaneously maintaining the myeloid system, capable of preventing the damage of chemotherapeutic agents. Drug Dev. Res. 58:386–389, 2003. © 2003 Wiley‐Liss, Inc.
ChemInform Abstract: Studies of Metallofullerene Primary Soots by Laser and Thermal Desorption Mass Spectrometry. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461 (2011)

The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infected volunteers from the first "mechanism validation" phase II clinical trial of a mutagenic base analog in which individuals previously treated with antiviral drugs received 1600 mg of KP1461 twice per day for 124 days. Plasma viral loads were not reduced, and overall levels of viral mutation were not increased during this short-term study, however, the mutation spectrum of HIV was altered. A large number (N = 105 per sample) of sequences were analyzed, each derived from individual HIV-1 RNA templates, after 0, 56 and 124 days of therapy from 10 treated and 10 untreated control individuals (>7.1 million base pairs of unique viral templates were sequenced). We found that private mutations, those not found in more than one viral sequence and likely to have occurred in the most recent rounds of replication, increased in treated individuals relative to controls after 56 (p = 0.038) and 124 (p = 0.002) days of drug treatment. The spectrum of mutations observed in the treated group showed an excess of A to G and G to A mutations (p = 0.01), and to a lesser extent T to C and C to T mutations (p = 0.09), as predicted by the mechanism of action of the drug. These results validate the proposed mechanism of action in humans and should spur development of this novel antiretroviral approach.
Cohesion and Complexity (2018)

This chapter draws attention to the complexity of the idea of 'community' as locality. Attention was drawn to the importance of network building in promoting and encouraging a sense of identification with particular localities. The chapter explores the complex relations that can emerge where old established communities are presented with newcomers, or indeed in the case of seaside resorts, a sudden seasonal influx of people, often from distant urban settings. These complex social settings provide the context for the ways in which people may understand, prepare or indeed respond to disaster events such as bushfire. The chapter reaffirms the view that 'community' is defined in a range of ways by residents and others, often for specific purposes. The tendency to understand community in terms of commonalities has been criticised for overlooking differences and inequalities. The dilemma in relation to policy development and practice is to recognise such variation of understanding and experience.
ChemInform Abstract: Diamine Ligands in Copper‐Catalyzed Reactions (2010)

Abstract Review: 229 refs.
Synthesis of Starlike N-(2-Hydroxypropyl)methacrylamide Copolymers:  Potential Drug Carriers (2000)

Starlike HPMA copolymers were synthesized by conjugating semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] macromolecules (ST-PHPMA, arm) with PAMAM dendrimers (core: G2, G3, G4). ST-PHPMA was synthesized by chain transfer free radical polymerization, and the terminal -COOH was activated with N-hydroxysuccinimide. Doxorubicin (DOX) was introduced into the starlike HPMA copolymer to evaluate its potential as a drug delivery system. The polymers were characterized with SEC, NMR, and UV. Cytotoxicity of the DOX containing starlike HPMA copolymer was determined on an A2780 human ovarian carcinoma cell line and compared with DOX-containing linear HPMA copolymers. The rate of in vitro DOX release from polymer--DOX conjugates in the presence of cathepsin B (CP-B, lysosomal cysteine proteinase) was determined and correlated with cytotoxicity results.