gebhart/patrepeval huggingface dataset:
Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase-2 expressing tumors (2017)

Cyclooxygenase-2 (COX-2) is an important biomarker in several tumors. Available imaging probes display relatively low tumor to background ratios (smaller than 2:1). We evaluated newly developed indomethacin (Ind) derivatives for in vivo molecular imaging of COX-2 expressing carcinoma. Radioiodinated Ind derivatives Ind-NH-(CH2)4-NH-3-[I-125]I-Bz ([I-125]5), Ind-NH-(CH2)4-NH-5-[I-124/125]I-Nic ([I-124/125]6) and Ind-NH-(CH2)4-NH-5-[I-125]I-Iphth ([I-125]7) were prepared from the respective SnBu3-precursors (45-80% radiochemical yield; > 95% radiochemical purity). The cellular uptake of [I-125]5 and [I-125]6 correlated with COX-2 expression determined by SDS page/Western blot analysis. [I-125]5 was predominantly localized in the cell membrane while [I-125]6 was internalized and displayed a diffuse and favorable cytoplasmic distribution. In contrast, [I-125]7 showed only low uptake in COX-2 positive cells. Co-incubation with the COX-2 inhibitor Celecoxib led to an almost complete suppression of cellular uptake of [I-125]5 and [I-125]6. In vivo molecular imaging using positron emission tomography (PET) in SCID mice xenografted with COX-2+ (HT29) and COX-2- (HCT116) human colorectal carcinoma cells was performed for [I-124]6. HT29 xenografts displayed a significantly higher uptake than HCT-116 xenografts (5.6 ± 1.5 vs. 0.5 ± 0.1 kBq/g, P < 0.05) with an extraordinary high tumor to muscle ratio (50.3 ± 1.5). Immunohistological staining correlated with the imaging data. In conclusion, the novel radioiodinated indomethacin derivative ([I-124/125]6) could become a valuable tool for development of molecular imaging probes for visualization of COX-2 expressing tumors.
On the performance of spatial-multiplexing MIMO-CDMA downlink receivers based on chip rate equalization and despreading (2008)

This paper is devoted to the performance analysis of downlink MIMO-CDMA receivers based on a chip rate MIMO equalizer followed by despreading. The various transmit antennas send independent streams and the spreading codes are scrambled Walsh-Hadamard sequences, the various transmit antennas being allocated different scrambling codes. The behaviour of the SINR provided by the receiver is first studied when the spreading factor and the number of users per antenna converge to +infin at the same rate. It is shown that the SINR converges towards a simple expression depending on the particular realization of the frequency selective channel between the base station and the mobile of interest. In order to get more insights on the long term performance, the ergodic sum-capacity delivered by the system is evaluated in the large number of antennas regime in the case the impulse response taps of the channel are Gaussian random matrices. A simple expression is obtained. It appears to be quite reliable for a realistic number of antennas, and is discussed in order to get some insights on the overall performance.
Bioaccessibility and intestinal cellular uptake could partly explain relative biopotency of D3 vitamers. (2016)

Bioaccessibility and intestinal cellular uptake could partly explain relative biopotency of D3 vitamers.. 4. international vitamin conference
Nanostructure technology (1988)

The ability to fabricate structures with lateral dimensions in the sub-100-nm range has opened a new field of research. This paper first reviews recent advances in nanolithography techniques, with a brief discussion of their relative merits and fundamental limits. Special emphasis is given to the scanning electron-beam method, which is the most widely used nanolithography method at the present time. The two main areas of nanostructure research are device technology and basic science. Highlights of a number of exploratory programs in these two areas are presented.
Electron energy-loss spectroscopy analysis of low-temperature plasma-enhanced chemically vapor deposited a-C:H films (1989)

Electron energy-loss spectroscopy (EELS) has been applied to the analysis of a-C:H films grown on various substrates by a unique low-temperature (&amp;lt;100 °C) plasma-enhanced chemical vapor deposition (PECVD) process using ethylene and hydrogen gases. EELS data are used to characterize the relative amounts of fourfold coordinated sp3 carbon bonding to threefold coordinated sp2 carbon bonding as well as the relative order/disorder due to substrate effects. Ellipsometric and transmission measurements provide optical constants for the PECVD a-C:H films.
Hexanuclear tungsten cluster structures: tetradecachlorohexatungstate(2-), tetradecabromohexatungstate(2-), and tetradecaiodohexatungstate(2-) relevance to unusual emissive behavior (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexanuclear tungsten cluster structures: tetradecachlorohexatungstate(2-), tetradecabromohexatungstate(2-), and tetradecaiodohexatungstate(2-) relevance to unusual emissive behaviorThomas C. Zietlow, William P. Schaefer, Behzad Sadeghi, Nhi Hua, and Harry B. GrayCite this: Inorg. Chem. 1986, 25, 13, 2195–2198Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ic00233a019https://doi.org/10.1021/ic00233a019research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Modeling microbubble production rates from expanding nozzle flow-focusing microfluidic devices (2012)

Flow-focusing microfluidic devices (FFMDs) have been reported to produce monodisperse microbubbles with tunable diameters determined by device geometry and input flow/pressure conditions. However, no model for microbubble production rate has yet been reported. In this paper, we develop a model describing the production rate of monodisperse spherical microbubbles from planar two-dimensional PDMS-based expanding-nozzle FFMDs as a function of gas pressure and liquid flow rate. High speed optical microscopy was used to determine the diameter and production rate. Microbubble generation was observed to occur in five discrete regimes. Within the spherical monodisperse regime, the generation cycle was characterized by two phases: bubbling and waiting. The generation cycle was found to be inversely proportional to liquid flow rate for a fixed gas pressure. Excellent agreement was found between predicted and measured microbubble production rate (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> = 0.91).
OUP accepted manuscript (2016)

Tissue deformation has to be taken into account when estimating the S- and T-wave of the ECG in electrophysiological simulations.
α-Iminocarboxamide Nickel Complexes:  Synthesis and Uses in Ethylene Polymerization (2005)

A series of nickel complexes containing α-iminocarboxamide, η1-benzyl, and PMe3 ligands were synthesized to identify structural features of neutral Ni complexes that are employed in ethylene polymerization and ethylene/functionalized norbornene copolymerizations. Variations in steric bulk on aryl substituents in the α-iminocarboxamide framework were used to probe N,N- versus N,O-binding modes. When the steric bulk is sufficiently large, as in [N-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino)propanamidato-κ2N,O]Ni(η1-CH2Ph)(PMe3) (1), [N-(2,6-diethylphenyl)-2-(2,6-diethylphenylimino)propanamidato-κ2N,O](η1-CH2Ph)(PMe3)nickel (2), and [N-(2,6-methyl-isopropylphenyl)-2-(2,6-methylisopropylphenylimino)propanamidato-κ2N,O](η1-CH2Ph)(PMe3)nickel (3), one observes N,O-binding. In the case of [N-(2,6-dimethylphenyl)-2-(2,6-dimethylphenylimino)propanamidato]((η1-CH2Ph)(PMe3)nickel (4), both, N,O- and N,N-bound modes can be obtained and isolated; the N,N structure is the thermodynamic product. N,N products are observed with smaller ligands, as in [N-phenyl-2-(2,6-diisopropylphenylimino)propanamidato-κ2N,N](η1-CH2Ph)(PMe3)nickel (5) and [N-(2,6-diisopropylphenyl)-2-(phenylimino)propanamidato-κ2N,N](η1-CH2Ph)(PMe3)nickel (6). Ethylene polymerization, upon activation with Ni(COD)2, is observed only with the N,O-bound species. NMR spectroscopy shows that addition of Ni(COD)2 to 5 and 6 results in removal of the phosphine and the formation of an η3-benzyl fragment. Furthermore, the phosphine-free complex [N-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino)propanamidato-κ2N,N](η3-CH2Ph)nickel (7) is also inactive toward ethylene polymerization. These observations suggest that ethylene polymerization is preferentially initiated by nickel complexes with N,O-bound α-iminocarboxamide ligands.
The CANadian Pediatric Weight Management Registry (CANPWR): Study protocol (2014)

This study will enable our interdisciplinary team of clinicians, researchers, and trainees to address foundational issues regarding the management of pediatric obesity in Canada. It will also serve as a harmonized, evidence-based registry and platform for conducting future intervention research, which will ultimately enhance the weight management care provided to children with obesity and their families.
Method Using Command Abstraction Library for Iterative Testing Security of Web Applications (2015)

A framework based on a scripting language is commonly used in Web application development, and high development efficiency is often achieved by applying several Agile development techniques. However, the adaptation of security assurance techniques to support Agile development is still underway, particularly from the developer's perspective. The authors have addressed this problem by developing an iterative security testing method that splits the security test target application into two parts on the basis of the code lifecycle, application logic (“active development code”) and framework (“used code”). For the former, detailed security testing is conducted using static analysis since it contains code that is changed during the iterative development process. For the latter, an abstraction library at the command granularity level is created and maintained. The library identifies the behavior of an application from the security assurance standpoint. This separation reduces the amount of code to be statically inspected and provides a mechanism for sharing security issues among application developers using the same Web application framework. Evaluation demonstrated that this method can detect various types of Web application vulnerabilities.
Catheter Ablation Related Mitral Valve Injury: The Importance of Early Recognition and Rescue Mitral Valve Repair (2014)

Circular mapping catheter entrapment and ablation at the mitral annulus are the most common etiologies of MV injury during catheter ablation. Close surveillance of the MV is needed during such procedures and early surgical repair is important for successful salvage if significant injury occurs.
Kinetics, cross-reactivity, and specificity of Bet v 1-specific IgG4 antibodies induced by immunotherapy with birch pollen (2013)

Our results indicate that BP-SIT may induce Bet v 1-specific IgG4 antibodies that cross-react with related food allergens and inhibit IgE binding by epitope competition.
A 3.9kHz bandwidth and 2μV offset current sensor analog front-end with a capacitively coupled amplifier using a dual frequency conversion technique (2023)

Precision current measurement with low offset and low gain error is essential for battery management systems to perform accurate State-of-Charge (SOC) estimation in battery-powered vehicles. The simultaneous sampling of current and voltage enables measurement of battery capacity and/or battery impedance to estimate battery’s State-of-Health SOH or internal properties [1]. The bandwidth of the current sensor front-end is required to be on the order of kHz for those applications. The system-level chopping CHL technique [2] is proposed to improve an analog front-end (AFE) input offset while the reset of integrator is required each time the CHL operates, which limits the signal bandwidth. To overcome this bandwidth limitation, an AFE for a current sensor with a capacitively coupled amplifier (CCA) followed by a $2^{\text {nd }}$-order $\Delta \Sigma$ modulator with correlated double sampling (CDS) and charge-preserving integration technique was proposed [3]. The CCA has a duty-cycled resistor to provide a DC bias to the o & input each time the polarity of the signal changes, and the operation causes the signal leakage, resulting in a AFE gain error. Moreover, an anti-aliasing filter (AAF) is required in automotive applications to attenuate unwanted noise as well as to protect the AFE from ESD noise. It also causes inherent gain errors due to voltage division by the impedance of the AAF and the CCA determined by the input capacitance of the CCA and sampling frequency. This paper proposes an analog front end for current sensors using a CCA with a dual frequency conversion technique in order to improve the CCA input impedance by reducing the operating frequency to half that of the $\Delta \Sigma$ modulator in the following stage. The proposed AFE shows $2 \mu \mathrm{V}$ offset and ± 0.2 % gain error with 3.9kHz bandwidth from $-50^{\circ} \mathrm{C}$ to $150^{\circ} \mathrm{C}$.
JOINT SOURCE/CHANNEL CODING FOR MUL'TICAST PACKET VIDEO (1995)

Current schemes for multicast packet video cope with congestion by adapting the transmission rate of a variable rate codec at the source. We propose a new approach, based on receiver- rather than source-adaptation, where a video source is encoded hierarchically with each layer of hierarchy distributed on a separate network channel. Each receiver can then dynamically adapt to local network capacity by adjusting the number of layers it receives. In order to deploy such a system, we must at the same time develop a layered codec tailored for this model. We present a prototype coder that has been designed specifically for our receiverbased congestion avoidance scheme. In order to evaluate the efficacy of our approach, we have implemented it in an existing Internet remote conferencing application and constrained the complexity of our design to run in real-time on standard workstations. Even with this constraint, our codec can generate a flexible range of layers while exhibiting reasonable compression performance.
Dynamic leakage current compensation in ferroelectric thin-film capacitor structures (2005)

We report on a measurement procedure to separate ferroelectric switching current and dielectric displacement current from the leakage current in leaky ferroelectric thin-film capacitor structures. The ac current response is determined for two adjacent frequencies. Taking advantage of the different frequency dependencies of the ferroelectric switching current, dielectric displacement current and ohmic current, the hysteresis loop is calculated without performing a static leakage current measurement, which causes a high dc field stress to the sample. The applicability of the proposed measurement procedure is demonstrated on a Pt∕Pb(Zr,Ti)O3∕IrO2 ferroelectric capacitor revealing a high leakage current.
Verbrücken von Rotaxanreifen – cyclochirale Bonnane (2006)

Brücken bauen: Die Reife eines [3]Rotaxans wurden intramolekular verbrückt, wobei cyclochirale, verzahnte Verbindungen entstanden, die als Bonnane (nach der Stadt Bonn) bezeichnet wurden (siehe Bild). Die Enantiomere und meso-Formen der Bonnane wurden an immobilisierten chiralen Phasen getrennt und charakterisiert. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z602002_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Special “Reviews” Issue on the Chemical Senses (2011)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTA Special "Reviews" Issue on the Chemical SensesCraig W. LindsleyCite this: ACS Chem. Neurosci. 2011, 2, 1, 1Publication Date (Web):January 19, 2011Publication History Published online19 January 2011Published inissue 19 January 2011https://pubs.acs.org/doi/10.1021/cn1001073https://doi.org/10.1021/cn1001073editorialACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views741Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (611 KB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Molecules,Neuroscience Get e-Alerts
Characteristics of $\hbox{HfO}_{2}$ /Poly-Si Interfacial Layer on CMOS LTPS-TFTs With $\hbox{HfO}_{2}$ Gate Dielectric and $\hbox{O}_{2}$ Plasma Surface Treatment (2008)

In this paper, high-performance complementary-metal-oxide-semiconductor low-temperature polycrystalline-silicon thin-film transistors (CMOS LTPS-TFTs) with HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectric are fabricated on one wafer for the first time. Low threshold voltage and excellent subthreshold swing can be achieved simultaneously for N- and P-channel LTPS-TFTs without hydrogenation. In addition, the impacts of the HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /poly-Si interfacial layer on N- and P-channel LTPS-TFTs are also specified. In order to enhance the characteristics of HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> LTPS-TFT further, oxygen plasma surface treatment is employed to improve the interface quality and passivate the defects of channel grain boundaries, thus increasing the carrier mobility and reducing the phonon scattering. The CMOS LTPS-TFTs with HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate dielectric and oxygen plasma treatment would be suitable for the application of system-on-panel.
Central in Vivo Nicotinic Acetylcholine Receptor Imaging Agents for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) (2009)

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are useful for non-invasive investigation of brain receptors. With these imaging techniques, changes in brain receptor densities and distributions during chronic drug treatments and disease progressions can be tracked for a long period. Appropriate radiolabeled imaging agents are necessary for PET and SPECT molecular imaging. Nicotinic acetylcholine receptors (nAChRs) play important roles in brain functions. The alpha4beta2 and alpha7 are the major nAChR subtypes in the brain. To date, several subtype selective radiolabeled ligands for nAChR have been reported. For the alpha4beta2 subtype, some agents are already applied for human studies, but only a few agents are developed for the alpha7 subtype. Here, we overview our results of [(125/123)I]5-iodo-3-(2(S)-azetidinylmethoxy)pyridine and 5-[11C]methyl-3-(2-(S)-azetidinylmethoxy)pyridine ([11C]5MA) for alpha4beta2 subtype imaging, and [11C](R)-2-methylamino-benzoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester ([11C](R)-MeQAA) for alpha7 subtype imaging.
Fork elongation estimation in a motorcycle suspension via Kalman-filter techniques for semi-active end-stop avoidance control (2017)

This paper is about the estimation of front suspension stroke in a motorcycle, oriented to the semi-active end-stop avoidance control. The proposed observer is based on a Kalman-filter that takes into account the external forces acting on suspension while the vehicle is turning or accelerating. Furthermore a practical state-reset strategy is proposed in order to improve estimation performances for wheelie manoeuvres and to limit the estimated state into suspension physical bounds. The experimental results show that the suspension position can be correctly estimated both on road and off-road driving conditions.
Applying super resolution to low resolution images for monitoring transmission lines (2021)

It is important for the electricity transmission and distribution (T&D) companies to patrol their own assets frequently in a wide area. however, the cost of patrolling throughout the area is budget threatening. The work on detecting the maintenance places where the vegetation encroachment problems occurred, is labor intensive, costly, and time-consuming, sometimes inapplicable due to the poor accessibility, and is thus, only practical on relatively small areas. Satellite imagery-based monitoring is reasonable and repeatable; hence it has a potential to replace the helicopter surveillance. Sentinel-2 imagery is one of the most famous satellite imageries with completely free of charge, however, its spatial resolution is relatively lower than high-cost satellite imagery such as PlanetScope or WorldView-3. In this research, we explored the effectiveness of super resolution. The refinement of spatial resolution from 10m/pix to 3.3m/pix (x3 SR) seemed to be extremely useful to assess trigonometric risk assessment, which leveraged the number of the pixels between transmission line and vegetation, and tree height information at the vegetation pixels. We employed the deep learning based super resolution model RDN (Residual Dense Network) to upsample the Sentinel-2 images. The training data is generated from the PlanetScope imagery whose resolution is 3.7m/pix. Deep learning based super resolution is generally effective to get 2-4 times finer resolution, therefore, the PlanetScope imagery is suitable to obtain the RDN model for x3 super resolution. We evaluated the performance of vegetation segmentation performance with and without super resolution in the areas along the transmission line. The experimental results showed that the imagery with super resolution yielded better result than the result without super resolution by 9.3% in weighted F1-score.