gebhart/patrepeval huggingface dataset:
Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort (2008)

Although the genetic determinants of personality have been intensively investigated especially since Cloninger proposed his psychobiological model of temperament and character, findings to date remain inconclusive and very few studies have addressed the topic in large population cohorts. In the current study we investigated one gene family in its entirety by addressing the role of all known dopamine receptor genes, DRD1-DRD5, on Cloninger's temperament traits in a Finnish population-based birth cohort. The study sample (n = 1,434) was ascertained from the Northern Finland Birth Cohort 1966 with over 5,000 study individuals tested at the age of 31 years. We utilized the genetic homogeneity and genealogical structure of this population to uncover putative effects of these genes on temperament traits at the population level. Our strategy utilizing a large birth cohort and its well established genealogical structure represents an optimal design for studying normally distributed traits. We also wished to provide a comprehensive view to one biologically relevant gene family instead of testing single candidate genes. We report evidence of association of several SNPs at the 5' end of dopamine receptor D2 (DRD2) with Novelty seeking (low) and Harm avoidance (high), and at the 3' end of DRD2 with Persistence. The strongest evidence of association emerged from females. Our study supports the involvement of the dopamine pathway in temperament traits, in particular underlining the role of DRD2 in Novelty seeking, Harm avoidance and Persistence.
Filtering land pattern for miniature mechanical switch connector (2008)

This paper reports on a novel design of land pattern for the assembly of miniature mechanical switch connectors (MMSC) onto printed circuit board (PCB). In contrast to conventional MMSC land pattern which features a non-selective response, the novel pattern offers a filtering response that can reject undesired spurious or interfering signals of a wireless system. The design has been developed for IEEE 11a/b/g WLAN applications in the 2.4GHz and 5GHz bands. Prototypes have been fabricated and experimentally verified to show their performance in comparison with the ones simulated electromagnetically in 3D.
Nanometer-Sized Particle Formation from NH3/SO2/H2O/Air Mixtures by Ionizing Irradiation (1998)

ABSTRACT Formation of nanometer-sized particles in NH3/SO2/H2O/Air mixtures by α-ray irradiation was studied experimentally to evaluate the effect of NH3 gas on the gas-to-particle conversion process. The total particle number concentration, the charged-particle fraction, and the electrical mobility distribution of particles generated in the ionization chamber were measured at various NH3, SO2, and H2O vapor concentrations and residence times of the gas mixture. Particle generation was enhanced in the presence of NH3, but the enhancement depends greatly on the SO2, NH3, and H2O concentrations; particle number concentrations at NH3 mixing ratios of 0.71–3.6 ppm were 2–4 times higher than those in the absence of NH3, but were constant in this range of NH3 concentration. The charged-particle fraction decreased with the addition of NH3, which indicated that ion-induced nucleation was decreased and homogeneous nucleation was enhanced. To evaluate the number concentrations of gaseous products, kinetic equations for the vapor species were solved on the basis of chain reactions initiated by OH radicals. From comparisons between experimental and predicted behavior, it is strongly suggested that the NH3SO3 species is the principal route to nanometer-sized particles in the NH3/SO2/H2O/Air mixture.
Sort-merge-join: an idea whose time has(h) passed? (2002)

Matching two sets of data items is a fundamental operation required in relational, extensible, and object-oriented database systems alike. However, the pros and cons of sort- and hash-based query evaluation techniques in modern query processing systems are still not fully understood. After our earlier research clarified strengths and weaknesses of sort- and hash-based query processing techniques and suggested remedies for the shortcomings of hash-based algorithms, the present paper outlines a number of further differences between sort-merge-join and hybrid hash join that traditionally have been ignored in such comparisons and render sort-merge-join mostly obsolete. We consolidate old and raise new issues pertinent to the comparison of sort- and hash-based query evaluation techniques and stir some thought and discussion among both academic and industrial database system builders.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Investigation of a cut-tree approach to network restoration from node loss (2002)

The loss of a node in a telecommunications transport network is considerably more severe than loss of a span. The network space capacity will generally be less than that required for 100% restoration of the affected transit demands. We show how a cut-tree analysis of the network can be used to guide network management to ensure that no demands remain completely disconnected and that individual recovery levels are nominally prorated to their pre-failure levels. The new method has been tested with favorable results against "ad hoc" node recovery using a basic path restoration protocol, and against the theoretical benchmark of multicommodity maximum flow. The procedure given has applications in network planning, network management, survivability analysis, and mesh restoration system design.
Spin-Canting Effects in GMR Sensors With Wide Dynamic Field Range (2021)

Magnetoresistive (xMR) sensors find extensive application in science and industry, replacing Hall sensors in various low field environments. While there have been some efforts in increasing the dynamic field range of xMR sensors, Hall sensors remain to dominate high field applications due to their wide linear range. Using a perpendicularly magnetized reference system and an in-plane free layer allows us to overcome this disadvantage of xMR sensors, and, furthermore, investigate spin-canting effects in interlayer exchange coupled perpendicular synthetic antiferromagnets (p-SAF). We achieved p-SAFs with exchange coupling fields of up to 10kOe, based on magnetic Co/Pt multilayer systems. The p-SAFs are either designed as “single” p-SAFs, where two Co/Pt multilayers are interlayer exchange coupled via a 4Å thick Ru spacer, or as “double” p-SAFs, where an additional Co layer is interlayer exchange coupled to the top multilayer. These p-SAFs are used for giant magnetoresistance (GMR) sensors with wide dynamic field range, limited only by the p-SAF's switching fields. Additionally, the magnetic anisotropy of the in-plane free layer is fully controlled, which allows saturation fields by design. With this, the entire spectrum from parallel to antiparallel alignment of free and reference layer is exploited, which yields the full GMR signal potential. We discovered through micromagnetic simulations that certain GMR transfer curves are dominated by spin-canting effects in the interlayer exchange coupled reference system. Finally, our simulation results lay out the correlation of the p-SAF's design parameters and its magnetization reversal behavior.
Copolymerization of Polythiophene and Sulfur To Improve the Electrochemical Performance in Lithium–Sulfur Batteries (2015)

We first report on the copolymerization of sulfur and allyl-terminated poly(3-hexylthiophene-2,5-diyl) (P3HT) derived by Grignard metathesis polymerization. This copolymerization is enabled by the conversion of sulfur radicals formed by thermolytic cleavage of S8 rings with allyl end-group. The formation of a C–S bond in the copolymer is characterized by a variety of methods, including NMR spectroscopy, size exclusion chromatography, and near-edge X-ray absorption fine spectroscopy. The S-P3HT copolymer is applied as an additive to sulfur as cathode material in lithium–sulfur batteries and compared to the use of a simple mixture of sulfur and P3HT, in which sulfur and P3HT were not covalently linked. While P3HT is incompatible with elementary sulfur, the new S-P3HT copolymer can be well dispersed in sulfur, at least on the sub-micrometer level. Sulfur batteries containing the S-P3HT copolymer exhibit an enhanced battery performance with respect to the cycling performance at 0.5C (799 mAh g–1 after 100 cycles for S-P3HT copolymer versus only 544 mAh g–1 for the simple mixture) and the C-rate performance. This is attributed to the attractive interaction between polysulfides and P3HT hindering the dissolution of polysulfides and the charge transfer (proven by electrochemical impedance spectroscopy) due to the homogeneous incorporation of P3HT into sulfur by covalently linking sulfur and P3HT.
Retinal Vessel Diameter as a Clinical Predictor of Diabetic Retinopathy Progression (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Coordinated Multipoint Transmission and Reception (2012)

This chapter describes the coordinated multipoint (CoMP) concepts, network architecture implications, and performance gains. Release 8 LTE radio networks are designed to be distributed where all the radio network functionalities are located in the base station. The chapter discusses the variants of downlink CoMP transmission, which differ substantially in the way multiple cells are involved in the transmission to single or multiple terminals. Uplink CoMP can be applied already for Release 8 UEs as uplink CoMP does not necessarily require any changes to the radio specifications. Naturally, the actual implementation of uplink CoMP requires changes on the network side. The downlink CoMP gains with two antenna transmissions are clearly lower than with four antennas. Further, the downlink CoMP is not a game-changer in terms of meeting the capacity growth demands since the average gains tend to be only modest. Controlled Vocabulary Terms antennas; long term evolution; radio networks; transmission networks
[The in vitro combination-effect of toremifene with CAF (cyclophosphamide, adriamycin, 5-fluorouracil) on growth of various human mammary carcinomas]. (1998)

Toremifene (TOR) is a new antiestrogenic agent, a triphenylethylene derivative that was developed as an alternative to tamoxifene (TAM). TOR has been observed to be more effective than TAM with milder toxicity at high doses. We examined the in vitro combination-effect of TOR with cyclophosphamide, adriamycin, 5-fluorouracil and three drug mixture (CAF) on the growth of various human mammary carcinomas. The combination shows a semi-additive or additive growth inhibitory effect on all estrogen positive cells used here except one cell line. In particular, the additive or synergic combination-effect was observed on TAM resistant cells. Furthermore, TOR exhibits a chemosensitizing activity in ADR-resistant cells by expressing P-glycoprotein coded by MDR-1 (multidrug resistance gene). The chemosensitizing activity is dose-dependent of TOR. As described above, the combination of TOR with CAF shows more than a semi-additive effect in this experiment. In conclusion, the addition of high-dose TOR to CAF therapy might be useful for advanced/recurrent breast cancer.
Design and optimization of subwavelength silicon photonics edge coupler for cleaved fibers (2018)

We propose a fiber-chip edge coupler based on a subwavelength grating in silicon-on-insulator (SOI) platform for coupling to cleaved and high numerical aperture (HNA) optical fibers (mode field diameter of 6.3 μm). Its robustness to fabrication errors and high tolerance to fiber misalignment (±1.5 μm for a 1 dB of excess loss) make it suitable for high-volume production, being a potential candidate for data center applications. Simulation results show a 1 dB bandwidth higher than 200 nm, a polarization dependent loss lower than 0.5 dB, and minimum coupling losses of 1.47 and 1.39 dB for TE and TM modes, respectively, considering a 204 μm-long mode converter.
Measurement of surface coupling coefficients between nematic liquid crystals and various substrates (1986)

Abstract There are still problems not fully solved concerning the characteristics and magnitude of interaction between liquid crystals and the surfaces of substrates. It is thought that the number of electrodes in a matrix display device can be increased and its display panel can contain a memory function by the weak boundary‐coupling effect (i.e., by reducing the coupling of the liquid crystal and the substrate surface). Thus, it is necessary to investigate the strength of the coupling between liquid crystals and the surfaces of various substrates. The coupling strength is measured by curve fitting of the electrostatic capacitance–applied voltage characteristic (the C ‐ V characteristic) of a nematic liquid crystal cell. In this method the measured result of the C ‐ V characteristic is compared with the result of calculation in which the surface coupling coefficient is used as parameter. Two kinds of surface treatment (i.e., oblique vacuum‐evaporation of silicon monoxide and rubbing after coating with polyvinyl alcohol film) are investigated. The nematic liquid crystals used in this study are phenyl cyclohexane‐based. The coupling coefficient is of the order of 10 −3 J/m 2 . When the temperature is raised, the coupling coefficient decreases.
60 GHz Interdigitated SOI integrated dipole antenna with a CPW balun (2006)

International audience
Otto Roelen als Wegbereiter der industriellen homogenen Katalyse (1994)

Abstract Otto Roelen hat 1938 die Oxosynthese (Hydroformylierung) entdeckt, noch während schwieriger Kriegsjahre die Grundzüge des Anwendungsbereiches bis hin zu einer ersten großtechnischen Anlage erarbeitet und damit das Tor zur Nutzung metallorganischer, homogen wirkender Katalysatoren geöffnet. Der gleichaltrige Walter Hieber erforschte fast zeitgleich die chemischen Grundlagen der verwendeten Katalysatoren, ohne von deren Anwendung zu wissen. Die Hydroformylierung zählt heute zu den bedeutendsten homogenkatalytischen Prozessen der Industrie. Die einmalige Chance einer zielgerichteten Zusammenarbeit von Industrie‐ und Hochschulchemikern am gleichen Problem einer wichtigen, neuen Synthese wurde damals nicht genutzt, wofür weniger die Zeitumstände als vielmehr Mentalitätsunterschiede zweier schwieriger Charaktere verantwortlich gemacht werden müssen: das alte Problem nicht planbarer Individuen in nicht planbarer Zeit. Eine Reihe von hier erstmals veröffentlichten Zeitdokumenten, vermehrt um die Berichte der Alliierten über „verborgene Reparationen”︁, gibt interessante Einblicke in die Art der Entdeckung und den späteren Ablauf der Entwicklung.
Sequence Specific DNA Cleavage by Conjugates of Benzotriazoles and Minor Groove Binders (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSequence Specific DNA Cleavage by Conjugates of Benzotriazoles and Minor Groove BindersSofia M. Touami, Clara C. Poon, and Paul A. WenderView Author Information Department of Chemistry, Stanford University Stanford, California 94305 Cite this: J. Am. Chem. Soc. 1997, 119, 32, 7611–7612Publication Date (Web):August 13, 1997Publication History Received2 April 1997Published online13 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971042zhttps://doi.org/10.1021/ja971042zrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views218Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal cleavage,Genetics,Light,Peptides and proteins,Screening assays Get e-Alerts
Accurate 3D locating and tracking of basketball players from multiple videos (2018)

With the development of pedestrian detection technologies, existing methods cannot simultaneously satisfy high-quality detection and fast calculation for practical applications, especially for accurate 3D locating and tracking of basketball players. We propose an algorithm which can robustly and automatically locate and track basketball players from multiple videos. After extracting the foregrounds, the voxels in the basketball court space are projected back to the foreground images. Occupied voxels are accumulated and smoothed based on integral space for acceleration. Two Gaussian Mixture Models including Grouping Gaussian Mixture Model(GGMM) and Locating Gaussian Mixture Model(LGMM) are designed for continuous locating and grouping players, and a simple blob detector is employed to handle out-of-bound players. Our algorithm is insensitive to occlusions, shadows, lights and computation errors.
Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target (2010)

If the shoe fits: TMC435, a noncovalent small-molecule inhibitor of the hepatitis C virus (HCV) NS3/NS4A protease, is currently undergoing clinical evaluation as an HCV therapeutic. In the crystal structure of the noncovalent NS3/NS4A protease–TMC435 complex the bound inhibitor exploits induced-fit binding. The new structure is consistent with the emerging view of viral resistance to NS3/NS4A protease inhibitors. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
On the surface of things: Images of the extraordinary in science (2008)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation David Stork; On the surface of things: Images of the extraordinary in science. Am. J. Phys. 1 June 2008; 76 (6): 599. https://doi.org/10.1119/1.2906400 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
GENETIC BLOCKADE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) INTENSIFIES THE DEVELOPMENT OF FIBROSIS IN A MOUSE MODEL OF DIABETES TYPE 1 (2009)

You have accessJournal of Urology1 Apr 2009GENETIC BLOCKADE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) INTENSIFIES THE DEVELOPMENT OF FIBROSIS IN A MOUSE MODEL OF DIABETES TYPE 1 Monica G Ferrini, Joanne Moon, Steve Rivera, Dolores Vernet, Jacob Rajfer, and Nestor F. Gonzalez-Cadavid Monica G FerriniMonica G Ferrini More articles by this author , Joanne MoonJoanne Moon More articles by this author , Steve RiveraSteve Rivera More articles by this author , Dolores VernetDolores Vernet More articles by this author , Jacob RajferJacob Rajfer More articles by this author , and Nestor F. Gonzalez-CadavidNestor F. Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60857-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "GENETIC BLOCKADE OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) INTENSIFIES THE DEVELOPMENT OF FIBROSIS IN A MOUSE MODEL OF DIABETES TYPE 1." The Journal of Urology, 181(4S), p. 301 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 301 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Monica G Ferrini More articles by this author Joanne Moon More articles by this author Steve Rivera More articles by this author Dolores Vernet More articles by this author Jacob Rajfer More articles by this author Nestor F. Gonzalez-Cadavid More articles by this author Expand All Advertisement PDF downloadLoading ...
Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation (2016)

Cytosine methylation, predominantly of the CpG sequence in vertebrates, is one of the major epigenetic modifications crucially involved in the control of gene expression. Due to the difficulty of reconstituting site-specifically methylated nucleosomal DNA at crystallization quality, most structural analyses of CpG methylation have been performed using chemically synthesized oligonucleotides, There has been just one recent study of nucleosome core particles (NCPs) reconstituted with nonpalindromic human satellite 2-derived DNAs. Through the preparation of a 146-bp palindromic α-satellite-based nucleosomal DNA containing four CpG dinucleotide sequences and its enzymatic methylation and restriction, we reconstituted a 'symmetric' human CpG-methylated nucleosome core particle (NCP). We solved the crystal structures of the CpG-methylated and unmodified NCPs at 2.6 and 3.0 Å resolution, respectively. We observed the electron densities of two methyl groups, among the eight 5-methylcytosines introduced in the CpG-fully methylated NCP. There were no obvious structural differences between the CpG-methylated 'symmetric NCP' and the unmodified NCP. The preparation of a crystallization-grade CpG-methylated NCP provides a platform for the analysis of CpG-methyl reader and eraser proteins.