gebhart/patrepeval huggingface dataset:
Demonstration test on purification systems of contaminated water using liquid–solid settling technology by flocculants (decontamination technology using high-pressure water) (2012)

For the purpose of decontaminating residential buildings, roads, rubble, and so on, the high-pressure water washing decontamination system had been developed, which are composed of a recovery system for contaminated washing water and mobile purification system of liquid–solid settling technology by flocculants. The high-pressure washing technology applied in this demonstration test can be used for both high- and ultrahigh-pressure washing decontamination and water surface chipping, by changing pumps and attachments. These systems were applied to decontaminate pools, concrete floor and side ditch around the pool in an elementary school located at Motomiya, Fukushima Prefecture as a demonstration test. Additionally, to compare decontamination effects, the tests, to chip and decontaminate surfaces of outer concrete and asphalt pavement had been conducted. From the results, high-pressure water jet decontamination systems have been practically proven.
3d image analysis and visualization of tubular structures (2003)

New multidetector High Resolution Computed-Tomography (HRCT) scanners can produce three-dimensional (3D) volumetric images of the human airway tree consisting of hundreds of two-dimensional (2D) sections. Immense volumetric data of vasculature is also obtained from micro-CT scanners. Virtual Endoscopy and Virtual Bronchoscopy (VB) systems have emerged to better deal with this data. These systems offer the user the ability to analyze the data with a wide variety of tools for better quantitative and diagnostic results. However, before these systems can be used, a significant amount of pre-processing must be performed. This preprocessing involves image segmentation, path planning, and quantitative analysis. The central focus of this thesis is in developing fast and reliable methods to perform these operations, thus allowing dependable clinical usage. The proposed methods were validated on a wide variety of images ranging from human airway data to the hepatic vasculature of rats. Phantom models were also used for validation. The methods for quantitative analysis were also compared to an existing semi-automatic method to prove correctness. The results show the clinical utility of these methods. Finally, the thesis proposes novel visualization tools to analyze the processed data and provide better navigation. These tools form a part of our VB system, the Virtual Navigator™. The robust methods presented in this thesis allow for clinically useful VB applications to aid physicians in image analysis and surgical guidance.
Basal Ganglia Studies with 3D Acquisition and 2D Reconstruction on a Retractable Septa PET Scanner (1994)

The SSRB method was found adequate for processing data related to human striatal imaging for this particular tomograph geometry.
Mycoplasma Pneumoniae. (1964)

s1 April 1964Mycoplasma Pneumoniae.Robert M. Chanock, M.D.Robert M. Chanock, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-733_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNonbacterial pneumonia is a syndrome of multiple etiology. In certain age groups and ecologic settings adenovirus, parainfluenza, and respiratory syncytial viruses may play an important role. A large segment of this syndrome still awaits an etiologic explanation. The viral agents just described are not active in those nonbacterial pneumonia illnesses in which a cold agglutinin response occurs during convalescence.During the past 5 years epidemiologic and volunteer studies have established that the organism originally described by Eaton and associates in 1944, is the etiologic agent in a majority of cold agglutinin positive pneumonia illnesses. Recently the Eaton agent has been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDEXTRAN 1 April 1964Volume 60, Issue 4Page: 733-734KeywordsAge groupsAgglutininsConvalescenceEpidemiologyEtiologyMycoplasma pneumoniaePneumonia Issue Published: 1 April 1964 PDF downloadLoading ...
Performance characteristics of phase-change integrated silicon nitride photonic devices in the O and C telecommunications bands (2020)

The evaluation and comparison of the optical properties in the O and C bands of silicon nitride rib waveguides with integrated Ge2Sb2Te5 phase-change cells is reported. In straight rib waveguides, a high transmission contrast is observed in both bands when the Ge2Sb2Te5 cell is switched between states, being up to 2.5 dB/μm in the C-band and 6.4 dB/μm in the O-band. In the case of silicon nitride ring resonator waveguides, high quality factor resonances (Q ∼ 105) are found in both bands, leading to the provision of an ON-OFF switch characterized by an extinction ratio of 12 and 18 dB in O and C bands respectively. Finally, with the view to provide a comparison of the wavelength-dependent optical switching of the phase-change cell, a 3-dimensional finite-element method simulation is performed and a comparison of the optical-to-thermal energy conversion in both bands given.
JPH203, an L-Type Amino Acid Transporter 1–Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells (2014)

Compared to most normal cells that express L-type amino acid transporter 2, L-type amino acid transporter 1 is highly expressed in cancer cells and presumed to support their elevated growth and proliferation. This study examined JPH203, a potent and selective L-type amino acid transporter 1 inhibitor, and its ability to suppress YD-38 human oral cancer cell growth. The YD-38 cells express L-type amino acid transporter 1 with its associating protein 4F2 heavy chain, but not L-type amino acid transporter 2. JPH203 and BCH, a non-selective L-type amino acid transporter inhibitor, completely inhibited l-leucine uptake in YD-38 cells. As expected, the intrinsic affinity of JPH203 to inhibit l-leucine uptake was far more efficient than BCH. Likewise, JPH203 and BCH inhibited YD-38 cell growth, with JPH203 being superior to BCH. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. These results suggest that the inhibition of L-type amino acid transporter 1 activity via JPH203, which may act as a potential novel anti-oral-cancer agent, leads to apoptosis by inducing the intracellular depletion of the neutral amino acids essential for cancer cell growth in YD-38 human oral cancer cells.
Hormonal control of gene expression: differential activation of rat bone marrow RNA polymerases by erythropoietin and testosterone. (1979)

Hormones play a role in the regulation of gene expression by inducing changes in enzyme patterns in target cells mediated by the synthesis of specific RNA molecules. Erythropoiesis has been used as a system for studying the molecular mechanism of regulation of gene action by means of two hormones: erythropoietin and testosterone. Experiments designed to correlate the biochemical action of both hormones on rat marrow cells are herein reported. Both factors seems to act at different biochemical and citological levels. Erythropoietin triggers the erythropoietic process acting on the erythropoietin sensitive cells (ESC), in which the hormone induces the synthesis of a high molecular weight RNA, which is the precursor of a functional 9 S messenger RNA. Testosterone seems to act on polychromatophilic erythroblasts, in which the synthesis of ribosomal RNA or its precursor is stimulated. The steroid enhances the nuclear ribonuclease activity, which could represent a control mechanism for the processing (maturation) of high molecular weight RNAs. The incorporation of 3H-GTP and 3H-UTP into RNA by isolated rat bone marrow nuclei is stimulated by erythropoietin and testosterone. Using alpha-amanitine and different ionic strength conditions it was found that erythropoietin enhances preferentially RNA polymerase II activity while testosterone increases RNA polymerase I activity. It is postulated that erythropoietin and testosterone act synergically to create the biochemical machinery for hemoglobin synthesis, the macromolecule that characterizes the erythropoietic process.
Figure S1 from Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography (2023)

Figure S1 from Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography
Ureas of 5‐Aminopyrazole and 2‐Aminothiazole Inhibit Growth of Gram‐Positive Bacteria. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Supplementary Figure from AZD4625 is a Potent and Selective Inhibitor of KRAS<sup>G12C</sup> (2023)

Supplementary Figure from AZD4625 is a Potent and Selective Inhibitor of KRAS&lt;sup&gt;G12C&lt;/sup&gt;
A split face study on the effect of an anti-acne product containing fermentation products of Enterococcus faecalis CBT SL-5 on skin microbiome modification and acne improvement (2022)

Antibiotic-resistant Cutibacterium acnes and dysbiosis of the skin microbiome are of increasing concern in acne treatment. Enterococcus faecalis, a widely used probiotic, has shown benefits for acne treatment by exerting antimicrobial activity against C. acnes. Therefore, this study aimed to investigate the efficacy and safety of an E. faecalis CBT SL-5-extract-containing lotion in patients with mild-to-moderate acne. Twenty patients were enrolled in this randomized, placebo-controlled, split-face comparative study. Patients were treated with E. faecalis lotion on one side of the face and a vehicle lotion on the other side for 4 weeks. The efficacy outcome measures included improvement in the investigators' assessment of acne severity, patient satisfaction, changes in skin parameters and diversity of the skin microbiome. The investigators' assessment score was significantly improved on the test side compared to the control side, after 2 weeks (p = 0.009) and 6 weeks (p < 0.0005). However, TEWL and skin hydration were not significantly different between the two groups. The phylogenetic diversity of the skin microbiota decreased over time in the skin samples of test side. In conclusion, E. faecalis CBT SL-5 extract can be a feasible and well-tolerated option for improving acne severity and skin microbiome dysbiosis in mild-to-moderate acne patients.
Drug Screening for COVID-19 using Supercomputer "Fugaku" (2021)

The expansion of COVID-19 in the world has not ended yet, and the situation in Japan is still unpredictable. Under these circumstances, the development of SARS-CoV-2 treatments such as vaccines and medicines is still underway. Since April of this year, we have been conducting research on the drug screening for SARS-CoV-2 using the supercomputer "Fugaku". In my talk, I would like to talk about the impact of the supercomputer "Fugaku" on drug discovery, by exemplifying the in silico drug screening for SARS-CoV-2.
Satellite profile in DVB-NGH (2012)

Digital Video Broadcasting - Next Generation Handheld (DVB-NGH) is a hybrid terrestrial-satellite standard conceived to facilitate rich media content consumption using a variety of mobile, handheld devices. Still under drafting, the DVB-NGH specifications are to be released current 2012 with the target of offering superior performance, robustness and coverage with respect to existing solutions. The purpose of this paper is to give an overview of the physical layer of the satellite component of DVB-NGH and to give some insight on the motivation and technical choices that were made during the specification phase, with a focus on the waveform choice and on the pilot grid design.
Short communication Experimental persistent infection with bovine viral diarrhea virus in white-tailed deer § (2007)

Bovineviraldiarrheavirus (BVDV) infections cause substantialeconomic losses tothe cattle industries. Persistentlyinfected (PI) cattle are the most important reservoir for BVDV. White-tailed deer (Odocoileus virginianus) are the most abundant species of wild ruminants in the United States and contact between cattle and deer is common. If the outcome offetal infection of whitetailed deer is similar to cattle, PI white-tailed deer may pose a threat to BVDV control programs. The objective of this study was to determine if experimental infection of pregnant white-tailed deer with BVDV would result in the birth of PI offspring. Nine female and one male white-tailed deer were captured and housed at a captive deer isolation facility. After natural mating had occurred, all does were inoculated intranasally at approximately 50 days of pregnancy with 10 6 CCID50 each of a BVDV 1 (BJ) and BVDV 2 (PA131) strain. Although no clinical signs of BVDV infection were observed or abortions detected, only one pregnancy advanced to term. On day 167 post-inoculation, one doe delivered a live fawn and a mummified fetus. The fawn was translocated to an isolation facility to be hand-raised. The fawn was determined to be PI with BVDV 2 by serial virus isolation from serum and white blood cells, immunohistochemistry on skin biopsy, and RT-PCR. This is the first report of persistent infection of white-tailed deer with BVDV. Further research is needed to assess the impact of PI white-tailed deer on BVDV control programs in cattle. # 2007 Elsevier B.V. All rights reserved.
Advanced EMI models for survey data processing: targets detection and classification (2014)

One of the most challenging aspects of survey data processing is target selection. The fundamental input for the classification is dynamic data collected along survey lines. These data are different from the static data obtained in cued mode and used for target classification. Survey data are typically collected using just one transmitter loop (the Z-axis loop) and feature short data point collection times and short decay transience. The collection intervals for each data point are typically 0.1 s, and the signal repetition rates are typically 90 or 270 Hz (in other words, the transient decay times are 2.7 ms or 0.9 ms). Reliable classification requires multiple side/angle illumination; i.e., to conduct reliable classification it is necessary to combine and jointly invert multiple data points. However, picking data points that provide optimal information for classifying targets is a difficult task. The traditional method plots signal amplitudes on a 2D map and picks peaks of signal level without properly accounting for the underlying physics. In this paper, the joint diagonalization is applied to survey data sets to improve data pre-processing and target picking. The JD technique is an EMI data analysis and target classification technique and is applicable for all next-generation multi-static array EMI sensors. The method extracts multi-static response data matrix eigenvalues. The eigenvalues are main characteristics of the data. Recent studies have demonstrated that the method has great potential to quickly estimate the number of potential targets and moreover classify these targets at the data pre-processing stage, in real time and without the need for a forward model. Another advantage of JD is that it provides the ability to separate signal from noise making it possible to de-noise data without distorting the signal due to the targets. In this paper the JD technique is used to process dynamic data collected at South West Proving Ground and Aberdeen Proving Ground (APG) sites using the 2 &times; 2 TEMTADS and OPTEMA systems, respectively. The joint eigenvalues are extracted as functions of time for each data point and summed/stacked together before being used to create detection maps. Once targets are detected, a set of data is chosen for each anomaly and inverted using the ortho-normalized volume magnetic source technique.
A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland (2015)

(Stem Cell Reports 4, 313–322; March 10, 2015)Due to a production error, the title of this paper was incorrectly written as “A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland CXCR4 Function in Mammary Progenitors.” The correct title appears in this correction, and the article has been updated online. (Stem Cell Reports 4, 313–322; March 10, 2015) Due to a production error, the title of this paper was incorrectly written as “A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland CXCR4 Function in Mammary Progenitors.” The correct title appears in this correction, and the article has been updated online. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult GlandShiah et al.Stem Cell ReportsFebruary 19, 2015In BriefIn this article, Khokha and colleagues use expression profiling and functional assays to identify CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), as a crucial instructor of hormone-induced mammary stem and progenitor cell function. Pharmacological inhibition of CXCR4 signaling abrogates progesterone-directed expansion of basal and luminal subsets, resulting in a marked reduction in CD49b+SCA-1− luminal progenitors and their functional capacity, and lobuloalveologenesis. Full-Text PDF Open Access
ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements (2017)

CIC rearrangements have been reported in two-thirds of EWSR1-negative small blue round cell tumors (SBRCTs). However, a number of SBRCTs remain unclassified despite exhaustive analysis. Fourteen SBRCTs lacking driver genetic events by RNA sequencing (RNAseq) analysis were collected. Unsupervised hierarchical clustering was performed using samples from our RNAseq database, including 13 SBRCTs with non-CIC genetic abnormalities and 2 CIC-rearranged angiosarcomas among others. Remarkably, all 14 study cases showed high mRNA levels of ETV1/4/5, and by unsupervised clustering most grouped into a distinct cluster, separate from other tumors. Based on these results indicating a close relationship with CIC-rearranged tumors, we manually inspected CIC reads in RNAseq data. FISH for CIC and DUX4 abnormalities and immunohistochemical stains for ETV4 were also performed. In the control group, only 2 CIC-rearranged angiosarcomas had high ETV1/4/5 expression. Upon manual inspection of CIC traces, 7 of 14 cases showed CIC-DUX4 fusion reads, 2 cases had DUX4-CIC reads, while the remaining 5 were negative. FISH showed CIC break-apart in 7 cases, including 5 cases lacking CIC-DUX4 or DUX4-CIC fusion reads on RNAseq manual inspection. However, no CIC abnormalities were detected by FISH in 6 cases with CIC-DUX4 or DUX4-CIC reads. ETV4 immunoreactivity was positive in 7 of 11 cases. Our results highlight the underperformance of FISH and RNAseq methods in diagnosing SBRCTs with CIC gene abnormalities. The downstream ETV1/4/5 transcriptional up-regulation appears highly sensitive and specific and can be used as a reliable molecular signature and diagnostic method for CIC fusion positive SBRCTs.
A Metadata Model Supporting Scalable Interactive TV Services (2005)

In this paper, we introduce a novel metadata model for describing scalable and interactive TV services that can be enriched with supplemental multimedia information. The model allows users to access such TV services not only via their traditional TV sets, but also via additional mobile devices like TabletPCs or PDAs. To achieve this, we segment the traditional linear program into sub-components, while separating device-independent and device-specific metadata. A realization of this model builds on the existing standards of TV-Anytime, MPEG-7 and MPEG-21. The model achieves a step towards the "Connected world" vision of the second specification phase of the TV-Anytime forum.
The effect of resin formulation on the degree of conversion and mechanical properties of dental restorative resins (1986)

The goal of this study was to determine the effects of resin formulation variables, such as diluent concentration, catalyst type and concentration and cure mode, on the degree of conversion of carbon double bonds and mechanical properties of dental restorative resins. Diametral tensile strength, compressive strength, hardness, flexural modulus and strength, and dynamic mechanical properties were tested, and the results were correlated to the degree of conversion results obtained by infrared analysis. The results showed a significant correlation between increased mechanical properties and higher degrees of conversion. Enhanced conversions were achieved by incorporating higher diluent and lower inhibitor concentrations into the resins. Ambient temperature properties were similarly enhanced by lower inhibitor concentrations, but were not enhanced by higher diluent concentration. Dynamic mechanical properties testing at oral and elevated temperatures elucidated possible differences in resin microstructure and network quality. The storage moduli decreased over the dental temperature range and was lower at all temperatures for resins with lower conversions. The glass transition temperature was also lower in resins with poorer conversions, suggesting that these resins may be more unstable at oral temperatures than more highly converted resins. Dynamic mechanical properties were most closely correlated to degree of conversion in these polymeric systems.
Correlations between Structural and Optical Properties of Peroxy Bridges from First Principles (2017)

This work aims at addressing the issue of the optical signature of peroxy bridges by using first-principles methods that combine density functional theory, GW (where G and W stand for one-particle Green function and screened Coulomb potential, respectively), and the solution of a Bethe–Salpeter equation on a bulk amorphous SiO2 model. We demonstrate that the presence of bridges induces broad and weak absorption bands between 3.2 and 7.5 eV. By analyzing the Si–O–O–Si dihedral angle distributions and the corresponding electronic structure, we show that the low overlap between O 2p states involved in the optical transitions together with the dihedral angle site-to-site disorder are at the origin of this weak and broad absorption. Moreover, the energy difference between the two first optical transitions depends linearly on the energy difference between the two first occupied defect-induced electronic states, i.e., depends on the dihedral angle of the bridge. This behavior may explain the longstanding controversy regarding the optical signature of peroxy bridges in amorphous SiO2. Because the correlation is independent of the specific hosting hard material, the results apply whenever the dihedral angle of the bridge has some degree of freedom.
Supplementation with glycoprotein 130 to culture media improves human embryo development and blastocyst formation rate in-vitro (2012)

Supplementation with glycoprotein 130 to culture media improves human embryo development and blastocyst formation rate in-vitro