gebhart/patrepeval huggingface dataset:
Abstract 4738: The BET family bromodomain inhibitor ABBV-075 is a promising therapeutic agent for acute myeloid leukemia and myelodysplastic syndrome (2016)

Abstract Small molecule inhibitors of the bromodomain and extraterminal domain (BET) proteins exhibit interesting activities in preclinical models of various cancer indications, and several of these inhibitors are currently under clinical investigation. ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered Phase 1 studies. Upon characterizing cellular responses to BET inhibitors across a large panel of cancer cell lines, we identified AML/MDS as one of the few cancer indications where BET inhibitors triggered robust apoptosis in cancer cell lines and in patient-derived cancer cells. The induction of apoptosis by BET inhibitors in AML/MDS cells may be partly attributed to their abilities to down regulate Bcl-XL and Bcl-2, and combining BET inhibitors with the Bcl-2 inhibitor venetoclax (ABT-199) resulted in robust cytotoxicity in AML/MDS cells. ABBV-075 exhibited significant antitumor efficacy as a monotherapy in flank xenograft models of AML and MDS. Furthermore, combining low doses of ABBV-075 with the standard of care agent azacitidine in the SKM1 model led to significant tumor regression, and the combination regimen was better tolerated than BETi monotherapy at doses that produced a similar degree of therapeutic benefit. Expression profiling of SKM1 tumors from mice treated with the ABBV-075/azacitidine combination or each of these agents as monotherapies revealed that ABBV-075 and azacitidine regulated a common set of biologic pathways. The combination of ABBV-075/azacitidine led to a more robust impact on these common pathways, which may partially contribute to the enhanced efficacy of the ABBV-075/azacitidine combination in the SKM-1 model. Citation Format: Mai H. Bui, Xiaoyu Lin, Xiaoli Huang, Leiming Li, Aparna Sarthy, Daniel Albert, Terry Magoc, Lloyd Lam, Paul Hessler, Tamar Uziel, Steven Elmore, Keith McDaniel, Warren Kati, Yu Shen. The BET family bromodomain inhibitor ABBV-075 is a promising therapeutic agent for acute myeloid leukemia and myelodysplastic syndrome. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4738.
Switching Property of Atomic Switch Controlled by Solid Electrochemical Reaction (2006)

We measured the switching time of an atomic switch that is operated by controlling the formation and annihilation of an atomic bridge in a nanogap between two electrodes using solid electrochemical reaction. The switching time becomes exponentially shorter with increasing the switching bias voltage. This exponential relation indicates that the switching time is determined by the solid electrochemical reaction, which is supported by theoretical estimation using a simple model. These results suggest the possibility that the atomic switch can be operated as fast as semiconductor devices currently used.
A SIP Based Next Generation Services Platform (2007)

Mobile network operators aims are offering new services to be competitive in the telecommunications market. However, the migration cost towards the third generation (3G) network is so high. This paper presents a proposal to offer a next generation services platform based on session initiation protocol (SIP). This solution is easy to implement and its cost is relatively low. Our solution takes into account the IP multimedia subssytem (IMS) service architecture specification proposed by the third generation partnership project (3GPP) providing ubiquitous characteristics for mobile users. In this way, our proposal becomes as a tool to allow an easy transition from 2.5 to 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> generation networks.
Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study (2017)

NCT01276509; Results.
Chirale Heterocyclencarbene in der asymmetrischen Homogenkatalyse (1996)

Die ee ‐Werte der Hydrosilylierung von Acetophenon mit dem Rhodiumkatalysator 1 sind zwar nicht hoch, dafür ist die Stabilität des Katalysators beeindruckend : Der gut verfügbare und leicht variierbare chirale Carbenligand bleibt in Lösung bis über 100°C am Metall gebunden, so daß auch keine Ligandenüberschüsse bei den katalytischen Reaktionen nötig sind. magnified image
Burn Depth Estimation—Man or Machine (1984)

A Burn Depth Indicator, utilizing reflectance ratios of red, green, and infrared light, has been devised and clinically tested for 18 months at our Burn Center. Using the endpoint of wound healing in less than or more than 3 weeks, clinical assessment by two experienced surgeons of intermediate depth wounds was compared to readings from the BDI. In about one third of cases the surgeons were unwilling to commit themselves to a prediction. In the cases where the surgeons were willing to make a prediction, they were incorrect about 25% of the time. The BDI was significantly more accurate than the clinical assessment in those predicted not to heal by the surgeons and maintained an accuracy of 79% in the wounds where the surgeons would not make a prediction. The BDI is portable, noninvasive, and provides an immediate reading. It may have utility as a triage tool for emergency rooms or combat situations, and has utility at present in our Burn Center as a more accurate tool than our clinical judgment in predicting which wounds should be excised and grafted during the first few days after injury.
Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors (2013)

Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We combined in vitro and in vivo approaches to test possible GHSR-mediated biological activity of dAG. Both AG (100 nmol/L) and dAG (100 nmol/L) significantly increased inositol triphosphate formation in human embryonic kidney-293 cells transfected with human GHSR. As expected, intracerebroventricular infusion of AG in mice increased fat mass (FM), in comparison with the saline-infused controls. Intracerebroventricular dAG also increased FM at the highest dose tested (5 nmol/day). Chronic intracerebroventricular infusion of AG or dAG increased glucose-stimulated insulin secretion (GSIS). Subcutaneously infused AG regulated FM and GSIS in comparison with saline-infused control mice, whereas dAG failed to regulate these parameters even with doses that were efficacious when delivered intracerebroventricularly. Furthermore, intracerebroventricular dAG failed to regulate FM and induce hyperinsulinemia in GHSR-deficient (Ghsr(-/-)) mice. In addition, a hyperinsulinemic-euglycemic clamp suggests that intracerebroventricular dAG impairs glucose clearance without affecting endogenous glucose production. Together, these data demonstrate that dAG is an agonist of GHSR and regulates body adiposity and peripheral glucose metabolism through a CNS GHSR-dependent mechanism.
On Chip Plasmonic Monopole Nano-Antennas and Circuits (2011)

Analogues of many radio frequency (RF) antenna designs such as the half-wave dipole and Yagi-Uda have been successfully adapted to the optical frequency regime, opening the door for important advances in biosensing, photodetection, and emitter control. Examples of monopole antennas, however, are conspicuously rare given the element's extensive use in RF applications. Monopole antennas are attractive as they represent an easy to engineer, compact geometry and are well isolated from interference due the ground plane. Typically, however, the need to orient the antenna element perpendicular to a semi-infinite ground plane requires a three-dimensional structure and is incompatible with chip-based fabrication techniques. We propose and demonstrate here for the first time that monopole antenna elements can be fashioned out of single element nanoparticles fabricated in conventional planar geometries by using a small nanorod as a wire reflector. The structure offers a compact geometry and the reflector element provides a measure of isolation analogous to the RF counterpart. This isolation persists in the conductive coupling regime, allowing multiple monopoles to be combined into a single nanoparticle, yet still operate independently. This contrasts with several previous studies that observed dramatic variations in the spectral response of conductively coupled particles. We are able to account for these effects by modeling the system using circuit equations from standard RF antenna theory. Our model accurately describes this behavior as well as the detailed resonance tuning of the structure. As a specific practical application, the monopole resonances are precisely tuned to desired protein absorption bands, thereby enhancing their spectroscopic signatures. Furthermore, the accurate modeling of conductive coupling and demonstrated electronic isolation should be of general interest to the design of complex plasmonic circuits incorporating multiple antennas and other current carrying elements.
High-Efficiency Thermophotovoltaic System That Employs an Emitter Based on a Silicon Rod-Type Photonic Crystal (2019)

Thermophotovoltaic systems in principle enable utilization of heat that is usually regarded as wasted energy. However, the wavelength selectivity of the thermal emitter required for high efficiencies is difficult to control with conventional designs. Here, we design a thermophotovoltaic system, comprising silicon rods as thermal emitter with a relatively narrow emission spectrum and photovoltaic cells with a band gap corresponding to 1.76 μm, and verify efficient power generation. By accurately measuring the heat flux that enters the emitter, the emitter temperature, and the electrical output power of the photovoltaic cells, we find that the actual system efficiency (ratio of output power to ingoing heat flux) is 11.2% at an emitter temperature of 1338 K and the output power density footprint is 0.368 W/cm2. The obtained efficiency is relatively high, i.e., 1.65 times that of the previously reported record value (6.8%). Further efficiency improvements may lead to development of distributed energy supplies using combustion heat.
Endothelial Cells Release a Chemoattractant for Retinal Pigment Epithelial Cells In Vitro (1985)

Though the pathogenesis of choroidal neovascular membranes is uncertain, there is evidence to support a primary dysfunction in the retinal pigment epithelium (RPE). This suggests the possibility that a healthy RPE may provide a physical and/or chemical barrier to subretinal endothelial cell invasion. It has recently been shown that RPE cells in culture produce an inhibitor of neovascularization. Histopathologic evidence suggests that RPE cells tend to surround new blood vessels and contain them. We therefore investigated the possibility that RPE cells are guided toward endothelial cells by chemoattractants. Using a modified Boyden chamber technique, we showed that endothelial cells in culture produce a chemoattractant for RPE cells. The active component is trypsin sensitive, stable at extremes of pH (3 through 10), and nondialyzable (12,000- to 14,000-dalton cutoff). It is partially heat stable but becomes completely heat stable in the presence of 1% sodium dodecyl sulfate. These are all characteristics of the previously described endothelial cell-derived growth factor, suggesting that this mitogen might be the chemoattractant. The ability of RPE cells to be attracted to sites of new blood vessel formation may enhance their potential function as inhibitors of neovascularization.
Business Case and Technology Analysis for 5G Low Latency Applications (2017)

A large number of new consumer and industrial applications are likely to change the classic operator's business models and provide a wide range of new markets to enter. This article analyses the most relevant 5G use cases that require ultra-low latency, from both technical and business perspectives. Low latency services pose challenging requirements to the network, and to fulfill them operators need to invest in costly changes in their network. In this sense, it is not clear whether such investments are going to be amortized with these new business models. In light of this, specific applications and requirements are described and the potential market benefits for operators are analysed. Conclusions show that operators have clear opportunities to add value and position themselves strongly with the increasing number of services to be provided by 5G.
Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. (2006)

Epidemiologic studies reported that the prevalence of hereditary non-polyposis colon cancer (HNPCC) in male is about 1.5-fold higher than that in female. Decreases in circulatory estradiol (E2) have been reported to downregulate the expression of E2 receptor (ER) and significantly increase the risk of colorectal cancer. Patients that received E2 replacement therapy were found to have a reduction in the incidence of colon adenoma and carcinoma. Furthermore, significant decreases in the expression of ER have been found in colorectal cancer specimens. These data strongly suggest the protective roles of E2 and ER against colorectal cancer. However, the mechanisms remain unexplored. LoVo cells were transient transfected to overexpress ER-beta, DNA fragmentation and caspase activity assay were performed to evaluate apoptotic effects. Western blotting was used to evaluate protein levels, and luciferase activity assay to measure the TNF-alpha promoter activity. Our data clearly demonstrated that E2 and ER-beta alone could upregulate p21 and p27 proteins, which further activate caspase-8 and caspase-9 to induce apoptosis in LoVo cell, and the ER-beta. effects were enhanced by E2. However, overexpressed ER-beta did not influence the expression and promoter activity of TNF-alpha. In addition, E2 and overexpressed ER-beta downregulated the beta-catenin proteins which cause the downregulation of its target genes, cyclin D1 and Rb, to inhibit the cell cycle and cell proliferation. The results indicate that overexpressed ER-beta may induce LoVo cell apoptosis and anti-proliferation by increasing p53 signaling in a ligand-dependent manner, and without hTNF-alpha involvement. Efforts aiming at enhancing ER-beta expression and/or activity may prove to be an attractive alternative therapy against colorectal cancer.
Test and Material Specifications for Dynamic Delamination Studies of Z-Pinned Laminates (2007)

Abstract : We specify tests by which we expect to demonstrate inference from test data of a mixed mode dynamic cohesive law that represents the crack-shielding effects of through-thickness reinforcement (e.g., z-pins) in a laminate.
ChemInform Abstract: AMID‐SCHUTZGRUPPE UND AMID‐TRAEGER FUER DIE FESTPHASEN‐PEPTIDSYNTH. (1970)

Abstract Die mit der p‐Methoxybenzylgruppe geschützten Aminosäurederivate (I)‐(XI) werden hergestellt.
Template induced chiral ordering in nematic liquid crystalline materials: A deuterium nuclear magnetic resonance study (2006)

Glancing angle deposition is used to create porous liquid crystal alignment layers with high aspect-ratio, three-dimensional features. We use solid-state deuterium nuclear magnetic resonance to determine the alignment of alpha deuterated 4′-pentyl-4-cyanobiphenyl in a 3.2μm thick SiO2 film comprised of independent, helical structures. Comparing measured spectra with models, we determine that the liquid crystalline molecules exhibit chiral ordering dictated by the features of the template films. In the plane of deposition the liquid crystalline molecules tilt away from the substrate normal at an average angle of 51°, which is commensurate with the helical features of the chiral template.
Functional exploration of the impact of fermented milk consumption withor withoutviable LAB on the composition and activityof the gutmicrobiotaby metaomic approaches (2019)

Objectifs\nLe microbiote intestinal humain est un écosystème complexe et dynamique. Il exerce de nombreuses fonctions biologiques et métaboliques. Le maintien de son équilibre (composition, activité) est important pour la santé et le bien-être de l’hôte et peut être influencé par de nombreux facteurs, comme l’alimentation. Les produits laitiers fermentés, qui contiennent une grande quantité de bactéries lactiques vivantes, peuvent contribuer à cet équilibre mais la compréhension de leur impact reste encore limitée. Ce travail a pour objectif de mieux comprendre, à partir de l’utilisation d’outils métaomiques, l’impact de la consommation de lait fermenté et de bactéries lactiques vivantes sur la composition et l’activité du microbiote intestinal. De plus, il vise à évaluer l’état physiologique et métabolique des bactéries lactiques en transit dans le tractus digestif. \nMatériels et Méthodes\nTrois groupes de 8 souris à flore humanisée (ie transplantation d’un microbiote fécal d’un individu sain à des souris axéniques) ont été alimentées avec (i) un régime contrôle sans lait (alimentation traditionnelle des souris + tampon PBS), (ii) un régime avec lait fermenté (alimentation traditionnelle des souris + un lait fermenté par les 2 bactéries du yaourt, Streptococcus thermophilus et Lactobacillus bulgaricus), ou (iii) un régime avec lait fermenté thermisé (alimentation traditionnelle des souris + un lait fermenté par les 2 bactéries du yaourt puis thermisé à 95°C pendant 25 min). La composition et l’activité du microbiote humain transplanté chez les souris ont été évaluées respectivement par métagénomique shotgun et métatranscriptomique à partir d’échantillons fécaux. \nRésultats principaux\nL’analyse quantitative et le suivi de l’activité du microbiote intestinal de souris à flore humanisée est réalisable grâce à des approches métaomiques. La consommation de lait fermenté (thermisé ou pas) ne modifie pas la composition du microbiote intestinal humain chez la souris mais a un impact significatif sur son activité. L’expression des gènes est modifiée pour la plupart des genres bactériens dominants, et modulant par conséquent leurs fonctions. Cet impact est d’autant plus important que la consommation de lait fermenté est régulière et prolongée dans le temps. En revanche, il n’a pas été possible de suivre l’activité des bactéries lactiques en transit qui sont minoritaires. \nConclusion\nCe travail met en évidence l’intérêt des méthodes métaomiques pour suivre l’impact de l’alimentation et ouvre des perspectives sur l’exploration des effets bénéfiques potentiels des laits fermentés sur le microbiote intestinal humain.\n
ChemInform Abstract: Reaction of Azoarenes with Tributyltin Hydride. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erratum: Light-Activated Sealing of Acellular Nerve Allografts following Nerve Gap Injury (2016)

Correction to: Light-Activated Sealing of Acellular Nerve Allografts following Nerve Gap InjuryJ Reconstr Microsurg 2016; 32(06): 421-430DOI: 10.1055/s-0035-1571247
Ultraviolet Light Cured Inks—A Review (1976)

The printing ink industry with annual sales of about $0. 7 billion is a small but vital part of the $37-billion-a-year graphic arts and communications industry (1). This industry is founded upon technical service because the ink formulations are tailored to the specific printing application. It is estimated that one million new ink formulations are produced each year, with another 4-5 million older formulations still available (2). Printing Processes This very large number of formulations is necessitated by the several different printing processes and the varying requirements of each printing application. There are three main printing processes: 1. letterpress; 2. lithography; 3. gravure. Figure 1 shows schematic representations of these three processes. In letterpress or relief 1Schematic of printing processes printing, the image area is raised above the plate surface. The ink is applied only to the image area (type-face) and then transferred to the paper substrate in the type-face plane. Flexography is a
Evaluation of the Impact of E-Services on the Residential Broadband Demand in the German Market (2020)

The worldwide broadband demand is increasing. A better broadband availability and higher broadband connection speeds depend also on the demand of the Internet users. For this reason, this pre-study investigates how the usage frequency of Internet services affects the bandwidth demand of private customers. To deepen the current status of knowledge about the customer needs regarding the usage of broadband connections, a survey in the Rhine-Main area in Germany has been performed. Here, especially the usage of different kinds of Internet services as well as the demand of bandwidth are raised. However, the first outcomes indicate that the usage of Internet services does not influence the demand for higher bandwidth.
Diarrhea and Reduced Levels of Antiretroviral Drugs: Improvement with Glutamine or Alanyl-Glutamine in a Randomized Controlled Trial in Northeast Brazil (2004)

The effects of therapy with glutamine and alanyl-glutamine on diarrhea and antiretroviral drug levels in patients with acquired immune deficiency syndrome (AIDS) were examined in a randomized, double-blinded, placebo-controlled study in northeast Brazil. Patients with AIDS and with diarrhea and/or wasting were randomized into 4 groups to determine the efficacy of glutamine or high- or low-dose alanyl-glutamine given for 7 days, compared with isonitrogenous glycine given to control subjects. All patients in whom baseline antiretroviral drug levels were determined had low levels 2 h after dosing. Gastrointestinal symptom scores improved with receipt of high-dose alanyl-glutamine (P<.05) or glutamine (P<.01). Antiretroviral drug levels increased in patients given alanyl-glutamine (P=.02) or glutamine (P=.03) by 113% (P=.02) and 14% (P=.01), respectively. Antiretroviral drug resistance mutations were common in all groups. The dose-related efficacy of alanyl-glutamine and glutamine in treating diarrhea and in increasing antiretroviral drug levels shows that these supplements may help to improve therapy for patients with AIDS who have diarrhea and/or wasting in developing, tropical areas.
Catalysis for Fuels: general discussion (2017)

Nico Fischer opened a general discussion of the paper by Nora de Leeuw: You have chosen Cu as a potential catalytic material and your calculations show that Cu is not the ideal surface to decompose hydrazine to H2. Which materials would you be looking into in the future? Have you found any desi
High-Frequency Carrier-Signal Voltage Selection for Stator Winding Fault Diagnosis in Inverter-Fed AC Machines (2008)

The diagnosis of stator winding faults in inverter-fed AC machines using an injected high-frequency carrier-signal voltage is analyzed in this paper. Measurement of the resulting carrier signals (either the negative-sequence carrier-signal current or the zero-sequence components) is used to detect turn faults at an incipient stage. The carrier frequency and magnitude are shown to have significant impact on the performance of the method, with the criteria for their selection being presented. The proposed technique shows low sensitivity to the working condition of the machine, i.e., torque level, flux levels, and fundamental excitation frequency.