gebhart/patrepeval huggingface dataset:
[Retrospective analysis of early and late results following surgical intervention in supraventricular arrhythmia]. (1995)

The results of surgical procedures for treatment of supraventricular tachycardias were assessed in 65 patients undergoing operation between January, 1980 and December, 1993. Indications for intervention were WPW (59 patients), atrial fibrillation (5 patients) and atrial flutter (1 patient). All cases of WPW were refractory to medical treatment and 14 of 58 patients had one or several syncopes, 4 of whom had to be resuscitated. The surgical treatment of these patients was dissection of an accessory atrioventricular pathway. 15 of these patients underwent heart operation for a different indication at the same time. A total of 60 accessory pathways were diagnosed preoperatively, while 4 were located intraoperatively. The reoperation rate was 3% (2 patients) due to persistent WPW. Incidence of total AV block after the operation was 7% (4 patients). In the late postoperative stage, 12 patients developed supraventricular tachycardias, but none of these cases required surgical treatment. The actuarial survival rate after 10 years was 100%, and after 14 years 96%. We conclude that surgical dissection of accessory pathways offers a good alternative in cases of unsuccessful catheter ablative procedures or in cases of concomitant heart surgery. In 6 patients with mitral valve surgery, associated chronic atrial fibrillation was found. A concomitant Maze-procedure was performed for the purpose of surgically converting the atrial fibrillation to a stable sinus rhythm. The early postoperative results are promising.
Extended‐release PEG–luciferin allows for long‐term imaging of firefly luciferase activity in vivo (2008)

Bioluminescence has gained favour in the last decade as an approach for observing tumours in vivo in a non-destructive manner. This very sensitive technique is based on light emission by the reaction of luciferin with the enzyme luciferase, as measured by a photodetector. Ever since the development of recombinant tumour cell lines that have been engineered to produce luciferase, a vast number of experiments have been carried out examining tumour growth, tumour metastasis and the effect of therapeutic regimens in such cases. A primary stumbling block, however, is the relatively short circulatory half-life of luciferin. In this paper, we propose the PEGylation of 6-amino-D-luciferin to extend its in vivo circulatory half-life, thus making the possibility of long-term observations in animals possible. The covalent attachment was through a carbamate linker that is known to hydrolyse in vivo, releasing the parent compound. Based on our studies, longer emission of the PEGylated luciferin was observed, as compared to free luciferin in mice bearing PC3 prostate tumours expressing luciferase. This result suggests that this reagent can be used in applications requiring extended monitoring of luciferase activation in vivo.
Improving data sharing in data rich environments (2017)

The increasing use of big data comes along with the problem of ensuring correct and secure data access. There is a need to maximise the data dissemination whilst controlling their access. Depending on the type of users different qualities and parts of data are shared. We introduce an alteration mechanism, more precisely a restriction one, based on a policy analysis language. The alteration reflects the level of trust and relations the users have, and are represented as policies inside the data sharing agreements. These agreements are attached to the data and are enforced every time the data are accessed, used or shared. We show the use of our alteration mechanism with a military use case, where different parties are involved during the missions, and they have different relations of trust and partnership.
Tailored molecular glass resists for scanning probe lithography (2015)

In the presented work solvent-free film preparation from tailored molecular glass resists, their thermal analysis, the characterization of etch resistance for plasma etching transfer processes, and the evaluation of the patterning performance using scanning probe lithography (SPL) tools, in particular electric field and thermal based SPL, are demonstrated. Therefore a series of fully aromatic spiro-based and tris-substituted twisted resist materials were systematically investigated. The materials feature very high glass transition temperatures of up to 173 °C, which allows solvent-free thin film preparation by physical vapor deposition (PVD) due to their high thermal stability. The PVD prepared films offer distinct advantages compared to spin coated films such as no pinholes, defects, or residual solvent domains, which can locally affect the film properties. In addition, PVD prepared films do not need a post apply bake (PAB) and can be precisely prepared in the nanometer range layer thickness. An observed sufficient plasma etching resistance is promising for an efficient pattern transfer even by utilizing only 10 nm thin resist films. Their lithographic resolution potential is demonstrated by a positive and a negative tone patterning using electric field, current controlled scanning probe lithography (EF-CC-SPL) at the Technical University of Ilmenau or thermal scanning probe lithography (tSPL) investigations at the IBM Research - Zurich. High resolution tSPL prepared patterns of 11 nm half pitch and at 4 nm patterning depth are demonstrated.
Fleur-de-lis Panniculectomy After Bariatric Surgery (2011)

There are many benefits of fleur-de-lis over traditional panniculectomy, even for medical necessity cases. There is limited undermining of tissue which minimizes/eliminates skin necrosis. Our experience with primarily fleur-de-lis panniculectomies shows a complication rate lower than most published data. Fleur-de-lis potentially creates a better symptom correction and cosmetic outcome by resecting maximal skin in both vertical and horizontal directions. These findings must be balanced against a potentially longer operation.
Conditional density estimation for physiological control systems (2002)

We introduce a connectionist architecture for predicting the conditional probability density for time series prediction in physiological control systems. The mean of the distribution is the target value, and variance is the confidence in the prediction. The methods are verified on a highly nonlinear system that exhibits deterministic chaos, and a brownian motion process that exhibits multimodal behavior.
Contribution-Based Energy-Trading Mechanism in Microgrids for Future Smart Grid: A Game Theoretic Approach (2016)

This paper designs a contribution-based energy-trading mechanism among microgrids in a competitive market. In each fixed time interval, each microgrid can be an energy provider or a consumer according to their energy generation and local demand. Under the trading mechanism, there is a distributor which gathers the surplus energy from providers and distributes it to the consumers based on the consumers' historical contribution level. To design the trading mechanism, a novel contribution-based energy allocation policy (EAP) is proposed. Each consumer who knows this distribution rule decides the amount of requesting energy in order to maximize its utility, i.e., the quantity of energy it will receive. Finally, the economic benefits of such trading mechanism are studied by analyzing the decision-making procedures of consumers and distributor. The problem is formulated as a noncooperative energy competition game (ECG) among the consumers. The existence and the uniqueness of Nash equilibrium (NE) are shown, and the NE solution is given as a closed form. Also, even though there are foolish consumers which do not take the given NE solution, a consumer which takes the NE solution will not lose out on its utility. The proposed energy-trading mechanism is stable enough to be applied to a practical microgrid trading market.
Rapid detection of phylloplane bacterium Enterobacter cloacae based on chitinase gene transformation and lytic infection by specific bacteriophages (2002)

The assay is simple, rapid, inexpensive, easy to perform and applicable to other strains. The system can be used for the routine monitoring of bacteria, which is important because of the increased use of transgenic strains of E. cloacae as an antagonistic biological control agent for plant diseases.
Body sensor data processing using stream computing (2010)

Advances in sensor technologies have accelerated the instrumentation of medical institutions. Today, modern intensive care units use sophisticated patient monitoring systems able to produce massive amounts of physiological streaming data. While these monitoring systems aim at improving patient care and staff productivity, they have the potential of introducing a data explosion problem. We address this problem by developing an open infrastructure upon which healthcare analytics can be built, managed, and deployed to analyze in real time physiological streaming data and turn this data into meaningful information for medical professionals. This infrastructure incorporates feature extraction and data mining functionalities for the discovery of clinical rules capable of identifying medically significant events. The system is based on a state of the art stream computing middleware. This paper presents this infrastructure from a programming model perspective. An exemplar application for arrhythmia detection is also described to illustrate its capabilities.
On the reported experimental evidence for the quasi‐Fermi level split in quantum‐dot intermediate‐band solar cells (2011)

ABSTRACT The reported experimental evidence for the quasi‐Fermi level split in quantum‐dot intermediate‐band solar cells is carefully examined. It is shown that the separation of the quasi‐Fermi level of the intermediate band from that of the conduction band is not consistent with the experimental results of the quantum efficiency and the luminescence intensity of the InAs/GaAs cells. The fact that the electroluminescence spectrum is too wide, extending much further than we expect on the basis of the measured quantum efficiency in the direction of increasing photon energies, indicates that the temperature of the optically active regions of the cell during the electroluminescence measurements is considerably higher than room temperature. The best agreement with the experimental results is achieved with a temperature of about 525 K. This temperature rise is probably a result of the heating effect of the relatively high forward current used in the luminescence experiments. It is argued that the lack of a quasi‐Fermi level split in this case is associated with the absence of a gap in the emission/absorption spectrum of sub‐bandgap photons. Copyright © 2011 John Wiley &amp; Sons, Ltd.
Griffithsin Has Antiviral Activity against Hepatitis C Virus (2011)

Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally experience rapid reinfection of their new liver graft. Current treatment protocols do not prevent graft reinfection and, in addition, an accelerated disease progression is observed. In the present study, we have evaluated a novel strategy to prevent HCV infection using a lectin, griffithsin (GRFT) that specifically binds N-linked high-mannose oligosaccharides that are present on the viral envelope. The antiviral effect of GRFT was evaluated in vitro using the HCV pseudoparticle (HCVpp) and HCV cell culture (HCVcc) systems. We show here that preincubation of HCVpp and HCVcc with GRFT prevents infection of Huh-7 hepatoma cells. Furthermore, GRFT interferes with direct cell-to-cell transmission of HCV. GRFT acts at an early phase of the viral life cycle by interfering in a genotype-independent fashion with the interaction between the viral envelope proteins and the viral receptor CD81. The capacity of GRFT to prevent infection in vivo was evaluated using uPA(+/+)-SCID mice (uPA stands for urokinase-type plasminogen activator) that harbor human primary hepatocytes in their liver (chimeric mice). In this proof-of-concept trial, we demonstrated that GRFT can mitigate HCV infection of chimeric mice. Treated animals that did become infected demonstrated a considerable delay in the kinetics of the viral infection. Our data demonstrate that GRFT can prevent HCV infection in vitro and mitigate HCV infection in vivo. GRFT treatment of chronically infected HCV patients undergoing liver transplantation may be a suitable strategy to prevent infection of the liver allograft.
Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation training for mammogram readers: a multi-centre study assessing diagnostic performance, using an enriched dataset (2022)

Single-day abMRI interpretation training for mammogram readers achieved an overall diagnostic performance within benchmarks published for fpMRI but was insufficient for diagnostic accuracy of mammogram readers new to breast MRI to match that of experienced fpMRI readers. Novice MRI reader performance improved during the reading task, suggesting that additional training could further narrow this performance gap.
Exploring Scheduling Effects on Task Performance with TaskInsight (2017)

The complex memory hierarchies of nowadays machines make it very difficult to estimate the execution time of the tasks as depending on where the data is placed in memory, tasks of the same type may end up having different performance. Multiple scheduling heuristics have managed to improve performance by taking into account memory-related properties such as data locality and cache sharing. However, we may see tasks in certain applications or phases of applications that take little or no advantage of these optimizations. Without understanding when such optimizations are effective, we may trigger unnecessary overhead at runtime level.In previous work, we introduced TaskInsight, a technique to characterize how the memory behavior of the application is affected by different task schedulers through the analysis of data reuse across tasks. We now use this tool to dynamically trace the scheduling decisions of multithreaded applications through their execution and analyze how memory reuse can provide information on when and why locality-aware optimizations are effective and impact performance.We demonstrate how we can detect particular scheduling decisions that produced a variation in performance, and the underlying reasons when applying TaskInsight to several of the Montblanc benchmarks. This flexible insight is key both for the programmer and runtime to allow assigning the optimal scheduling policy to certain executions or phases.
Automatic real-time guidance of laser machining with inline coherent imaging (2010)

Optical coherence imaging can measure hole depth in real-time (> 20 kHz) during laser drilling without being blinded by intense machining light or incoherent plasma emissions. Rapid measurement of etch rate and stochastic melt relaxation makes these images useful for process development and quality control in a variety of materials including metals, semiconductors and dielectrics. The ability to image through the ablation crater in materials transparent to imaging light allows the guidance of blind hole cutting even with limited a priori knowledge of the sample.Significant improvement in hole depth accuracy with the application of manual feedback from this imaging has been previously demonstrated [1]. However, the large quantity of raw data and computing overhead are obstacles for the application of coherent imaging as a truly automatic feedback mechanism. Additionally, the high performance components of coherent imaging systems designed for its traditional application in biological imaging are costly and may be unnecessary for materials processing. In this work, we present a coherent imaging system design that costs less than a fifth of comparable commercial products. We also demonstrate streamlined image processing suited for automated feedback that increases processing speed by two orders of magnitude.
Analysis of a Spin-Polarized Electron Beam Using the Mott Spin Analyzer I. (1994)

We developed a Mott analyzer of the spherical accelerator type, to measure the spin polarization of electrons extracted from a ferro-magnetic tip or a GaAs sample. This analyzer was designed for a low-acceleration voltage (40 kV). Inelastic scattered electrons are retarded by spherical electrodes. This paper reports the spin polarization of electrons extracted from negative electron affinity (NEA)-GaAs. It was found that this type of Mott analyzer involves a few problems to be solved.
A current reconstruction algorithm for three-phase inverters using integrated current sensors in the low-side switches (2004)

Power semiconductor switches that include integrated pilot current sensors create opportunities to eliminate external current sensors in three-phase inverter applications. Each of the three conventional low-side power switches in a three-phase inverter can be replaced by one of these special devices that is designed to provide a sensing level current that accurately mirrors its total forward current. Recognizing that the output current in each phase flows through the low-side switch for only a portion of the fundamental cycle, a technique has been developed to reconstruct the full phase current waveforms for R-L loads using only the incomplete phase current measurements. The performance characteristics of the proposed current reconstruction technique are experimentally verified, including demonstration of a closed-loop three-phase current regulator using the reconstructed current feedback from the integrated pilot current sensors.
Comment on The Ecstasy and Agony of Assay Interference Compounds (2017)

2017 , 57 , 387 - 390 ) is examined critically. When assessing assay hits from screening, it is important to draw a distinction between false positives, that have no effect on target function, and compounds that affect target function through an undesirable mechanism of action. Observation of frequent-hitter behavior for a compound should be regarded as circumstantial evidence, rather than definitive proof, that the compound has interfered with assay readouts or acted through an undesirable mechanism of action. The applicability domain of published (Baell and Holloway J. Med. Chem. 2010 , 53 , 2719 - 2740 ) Pan Assay INterference compoundS (PAINS) filters is limited by the narrow scope of the proprietary data used to derive them. It is suggested that journal guidelines for authors should not prescribe, as those for the Journal of Medicinal Chemistry appear to do, that activity in assays reported for compounds that match PAINS filters be treated any differently from that for compounds that do not match PAINS filters. It is argued that use of models based on proprietary data in the evaluation of manuscripts would contradict the editorial policy of any journal that deemed the use of proprietary data to be unacceptable in modeling studies.
Searches for lepton-flavour-violating decays of the Higgs boson in s=13 TeV pp collisions with the ATLAS detector (2019)

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H e and H , performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton-proton collisions at a centre-of-mass energy s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb -1 . No significant excess is observed above the expected background from Standard Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34 +0.13 -0.10 %) and 0.28% (0.37 +0.14 -0.10 %) for H e and H , respectively.
Support for Application IO Hints (2011)

This document proposes a new IO_ADVISE operation for NFSv4.2 that
clients can use to communicate expected I/O behavior to the server. By
communicating future I/O behavior such as whether a file will be
accessed sequentially or randomly, and whether a file will or will not
be accessed in the near future, servers can optimize future I/O
requests for a file by, for example, prefetching or evicting data.
This operation can be used to support the posix_fadvise function as
well as other applications such as databases and video editors.
Experimental Evaluation of NB-IoT Private Networks for Process Automation (2022)

Narrowband Internet-of-Things (NB-IoT) is a 3rd generation partnership project (3GPP) standardized cellular technology, adopted for 5G and optimized for massive Machine Type Communication (mMTC). Applications are anticipated around infrastructure monitoring, asset management, smart city and smart energy applications. In this paper, we evaluate the suitability of NB-IoT for private (campus) networks in industrial environments, including complex cloud-based applications around process automation. An end-to-end system has been developed, comprising of a sensor unit connected to a NB-IoT modem, a base station (gNodeB) equipped with a beamforming array and a local (private) network architecture comprising a sensor management system in the edge cloud. The experimental study includes field tests in realistic industrial environments with latency, reliability and coverage measurements. The results show a good suitability of NB-IoT for process automation with high scalability, low-power requirements and moderate latency requirements.
Functional MRI of the Lungs Using Single Breath-Hold and Self-Navigated Ultrashort Echo Time Sequences (2020)

Breath-hold and self-navigated 3D UTE sequences yield proton density-weighted images of the lungs that are similar in quality, and both techniques are suitable for functional image analysis.<i>Supplemental material is available for this article.</i>© RSNA, 2020.
Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A (1999)

There is a growing body of evidence demonstrating that Raf-1 is phosphorylated on tyrosines upon stimulation of a variety of receptors. Although detection of Raf-1 tyrosine phosphorylation has remained elusive, genetic analyses have demonstrated it to be important for Raf-1 activation. Here we report new findings which indicate that Raf-1 tyrosine phosphorylation is regulated in vivo. In both a mammalian and baculovirus expression system, a kinase-inactive allele of Raf-1 was found to be tyrosine phosphorylated at levels much greater than that of wild-type Raf-1. The level of tyrosine phosphate on Raf-1 was markedly increased upon treatment with phosphatase inhibitors either before or after cell lysis. Cdc25A was found to dephosphorylate Raf-1 on tyrosines that resulted in a significant decrease in Raf-1 kinase activity. In NIH 3T3 cells, coexpression of wild-type Raf-1 and phosphatase-inactive Cdc25A led to a marked increase in Raf-1 tyrosine phosphorylation in response to platelet-derived growth factor. These data suggest that the tyrosine phosphorylation of Raf-1 is regulated not only by itself but also by Cdc25A.