gebhart/patrepeval huggingface dataset:
An example of a non-associative Moufang loop of point classes on a cubic surface (2023)

Abstract Let V be a cubic surface defined by the equation $$T_0^3+T_1^3+T_2^3+\theta T_3^3=0$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msubsup> <mml:mi>T</mml:mi> <mml:mn>0</mml:mn> <mml:mn>3</mml:mn> </mml:msubsup> <mml:mo>+</mml:mo> <mml:msubsup> <mml:mi>T</mml:mi> <mml:mn>1</mml:mn> <mml:mn>3</mml:mn> </mml:msubsup> <mml:mo>+</mml:mo> <mml:msubsup> <mml:mi>T</mml:mi> <mml:mn>2</mml:mn> <mml:mn>3</mml:mn> </mml:msubsup> <mml:mo>+</mml:mo> <mml:mi>θ</mml:mi> <mml:msubsup> <mml:mi>T</mml:mi> <mml:mn>3</mml:mn> <mml:mn>3</mml:mn> </mml:msubsup> <mml:mo>=</mml:mo> <mml:mn>0</mml:mn> </mml:mrow> </mml:math> over a quadratic extension of 3-adic numbers $$k=\mathbb {Q}_3(\theta )$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>k</mml:mi> <mml:mo>=</mml:mo> <mml:msub> <mml:mi>Q</mml:mi> <mml:mn>3</mml:mn> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>θ</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> , where $$\theta ^3=1$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mi>θ</mml:mi> <mml:mn>3</mml:mn> </mml:msup> <mml:mo>=</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:math> . We show that a relation on a set of geometric k-points on V modulo $$(1-\theta )^3$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>1</mml:mn> <mml:mo>-</mml:mo> <mml:mi>θ</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mn>3</mml:mn> </mml:msup> </mml:math> (in a ring of integers of k ) defines an admissible relation and a commutative Moufang loop associated with classes of this admissible equivalence is non-associative. This answers a problem that was formulated by Yu. I. Manin more than 50 years ago about existence of a cubic surface with a non-associative Moufang loop of point classes.
CRISPR/Cas9-mediated targeted mutagenesis for functional genomics research of crassulacean acid metabolism plants (2019)

Crassulacean acid metabolism (CAM) is an important photosynthetic pathway in diverse lineages of plants featuring high water-use efficiency and drought tolerance. A big challenge facing the CAM research community is to understand the function of the annotated genes in CAM plant genomes. Recently, a new genome editing technology using CRISPR/Cas9 has become a more precise and powerful tool than traditional approaches for functional genomics research in C3 and C4 plants. In this study, we explore the potential of CRISPR/Cas9 to characterize the function of CAM-related genes in the model CAM species Kalanchoë fedtschenkoi. We demonstrate that CRISPR/Cas9 is effective in creating biallelic indel mutagenesis to reveal previously unknown roles of blue light receptor phototropin 2 (KfePHOT2) in the CAM pathway. Knocking out KfePHOT2 reduced stomatal conductance and CO2 fixation in late afternoon and increased stomatal conductance and CO2 fixation during the night, indicating that blue light signaling plays an important role in the CAM pathway. Lastly, we provide a genome-wide guide RNA database targeting 45 183 protein-coding transcripts annotated in the K. fedtschenkoi genome.
T-cell co-stimulatory blockade in transplantation: two steps forward one step back! (2013)

Targeting co-stimulatory pathways were found to be much more complex than initially anticipated due to the interplay between not only various co-stimulatory pathways but also various co-inhibitory ones. In addition, co-stimulatory signals have different roles in diverse immune cell types. Therefore, targeting CD28 ligands with cytotoxic T lymphocyte antigen-4 (CTLA4)-Ig may have some deleterious effects, including the inhibition of regulatory T cells, blockade of co-inhibitory signals (CTLA4) and promotion of Th17 cells. Co-stimulatory independence of memory T cells was another unforeseen limitation. Learning how to better integrate co-stimulatory targeting with other immunosuppressive agents will be critical for the improvement of long-term graft survival.
Kinetics of lipid metabolism in cancer cells (Conference Presentation) (2018)

Epithelial breast cells, which are involved in the production of milk fats, display altered lipid metabolism when they grow more malignant. At the same time, breast cancer cells show a higher degree of glycolysis, a mechanism to meet an increased demand for biomass as cells proliferate. Somewhat counterintuitively, breast cancer cells exhibit lower amounts of stored lipid, while glycolysis rates are up. We have investigated the kinetics of glycolysis, lipid synthesis, and lipid consumption rates in healthy and diseased epithelial breast cells. Using stimulated Raman scattering (SRS) microscopy of deuterated precursors, the cellular chemistry can be followed in space and time, revealing a clear link between glycolytic rate and the kinetics of lipid metabolism.
Carbonation Reaction of Calcium Silicate Hydrates by Hydrothermal Synthesis at 150°C in OPC-γ-Ca<sub>2</sub>SiO<sub>4</sub>-α-Quartz Systems (2007)

In order to develop organic-fiber reinforced building materials with long-term stability and durability, the carbonation of autoclaved calcium silicate hydrate hardening bodies, prepared by low-temperature synthesis (150°C) in Ordinary Portland Cement (OPC)-γ-Ca2SiO4 (γ-C2S)-α-quartz systems, has been investigated. The CO2 absorption decreased remarkably as the water-to-powder ratio (w/p) of the samples decreased, and the carbonation of the samples was inhibited. In addition, this tendency became remarkable by the use of γ-C2S, and carbonation was fully inhibited in the case where the mass ratio of the starting materials OPC, γ-C2S and α-quartz was 1:4:5. It is estimated that only vaterite, which was based on residual γ-C2S after accelerated carbonation and had a lower density than calcite and aragonite, filled the pores and densified the sample.
Identification of PDE6D as a Molecular Target of Anecortave Acetate via a Methotrexate-Anchored Yeast Three-Hybrid Screen (2013)

Glaucoma and age-related macular degeneration are ocular diseases targeted clinically by anecortave acetate (AA). AA and its deacetylated metabolite, anecortave desacetate (AdesA), are intraocular pressure (IOP)-lowering and angiostatic cortisenes devoid of glucocorticoid activity but with an unknown mechanism of action. We used a methotrexate-anchored yeast three-hybrid (Y3H) technology to search for binding targets for AA in human trabecular meshwork (TM) cells, the target cell type that controls IOP, a major risk factor in glaucoma. Y3H hits were filtered by competitive Y3H screens and coimmunoprecipitation experiments and verified by surface plasmon resonance analysis to yield a single target, phosphodiesterase 6-delta (PDE6D). PDE6D is a prenyl-binding protein with additional function outside the PDE6 phototransduction system. Overexpression of PDE6D in mouse eyes caused elevated IOP, and this elevation was reversed by topical ocular application of either AA or AdesA. The identification of PDE6D as the molecular binding partner of AA provides insight into the role of this drug candidate in treating glaucoma.
Challenges in sub-surface fluorescence diffuse optical imaging (2007)

A fully non-contact CCD-based approach to sub-surface fluorescence diffuse optical imaging is presented. An overview of CCD-noise sources are described and a possible solution for obtaining an adequate SNR in CCD-based diffuse optical imaging is implemented. To examine the impact of excitation and remission light attenuation in this geometry, the linearity of response in recovering object position was examined in simulations, with respect to changes in target size, target-to-background contrast, and depth. To provide insight regarding the technological complications of sub-surface imaging, liquid phantom experiments were performed for targets of size 4mm, 8mm and 14mm having 10:1 target-to-background contrast. Overall, the results indicate that steps must be taken to eliminate blooming artifacts, perhaps by physically blocking the active source as it is projected onto the CCD chip. In general, response linearity in the recovered target centroid position, size, and fluorophore concentration as well as complications arising due to partial volume sampling effects are expected to improve if prior structural images obtained from another modality are incorporated into the DOT reconstruction algorithm.
Search for pair and single production of vectorlike quarks in final states with at least one Z boson decaying into a pair of electrons or muons in pp collision data collected with the ATLAS detector at s=13  TeV (2018)

Search for pair and single production of vectorlike quarks in final states with at least one Z boson decaying into a pair of electrons or muons in pp collision data collected with the ATLAS detector at ffiffi s p = 13 TeV M. Aaboud et al.
Surface Acoustic Devices: UV Direct Write Metal Enhanced Redox (MER) Domain Engineering for Realization of Surface Acoustic Devices on Lithium Niobate (Adv. Mater. Interfaces 4/2014) (2014)

In article 1400006, D. Yudistira and co-workers introduce a new and highly versatile domain patterning method, ultraviolet direct write Metal Enhanced Redox (UV direct write MER), that achieves deep domains with practically no thermally induced damage on the surface of lithium niobate crystals. Such a technique enables the fabrication of practical piezoelectric acoustic superlattice structures on 128° YX-cut LiNbO3, the most widely used crystal cut for surface acoustic wave applications.
Matrix Exponential Learning Schemes With Low Informational Exchange (2019)

We consider a distributed resource allocation problem in networks where each transmitter-receiver pair aims at maximizing its local utility function by adjusting its action matrix, which belongs to a given feasible set. This problem has been addressed recently by applying a matrix exponential learning (MXL) algorithm, which has a very appealing convergence rate. In this learning algorithm, however, each transmitter must know an estimate of the gradient matrix of the local utility. The knowledge of the gradient matrix at the transmitters incurs a high signaling overhead, especially that the matrix size increases with the dimension of the action matrix. In this paper, we therefore, investigate two strategies in order to decrease the informational exchange per iteration of the algorithm. In the first strategy, each receiver sends at each iteration part of the elements of the gradient matrix with respect to a certain probability. In the second strategy, each receiver feeds back “sporadically” the whole gradient matrix. We focus on the analysis of the convergence of the MXL algorithm to optimum under these two strategies. We prove that the algorithm can still converge to optimum almost surely. Upper bounds of the average convergence rate are also derived in both situations with general step-size setting, from which we can clearly see the impact of the incompleteness of the feedback information. The proposed algorithms are applied to solve the energy efficiency maximization problem in a multicarrier multiuser multiple-input and multiple-output (MIMO) network. Simulation results further corroborate our claim.
Synthetic Control of Intrinsic Defect Formation in Metal Oxide Nanocrystals Using Dissociated Spectator Metal Salts (2022)

Crystallographic defects are essential to the functional properties of semiconductors, controlling everything from conductivity to optical properties and catalytic activity. In nanocrystals, too, defect engineering with extrinsic dopants has been fruitful. Although intrinsic defects like vacancies can be equally useful, synthetic strategies for controlling their generation are comparatively underdeveloped. Here, we show that intrinsic defect concentration can be tuned during the synthesis of colloidal metal oxide nanocrystals by the addition of metal salts. Although not incorporated in the nanocrystals, the metal salts dissociate at high temperatures, promoting the dissociation of carboxylate ligands from metal precursors, leading to the introduction of oxygen vacancies. For example, the concentration of oxygen vacancies can be controlled up to 9% in indium oxide nanocrystals. This method is broadly applicable as we demonstrate by generating intrinsic defects in metal oxide nanocrystals of various morphologies and compositions.
ACT-Vision: active collaborative tracking for multiple PTZ cameras (2009)

We describe a novel scalable approach for the management of a large number of Pan-Tilt-Zoom (PTZ) cameras deployed outdoors for persistent tracking of humans and vehicles, without resorting to the large fields of view of associated static cameras. Our system, Active Collaborative Tracking - Vision (ACT-Vision), is essentially a real-time operating system that can control hundreds of PTZ cameras to ensure uninterrupted tracking of target objects while maintaining image quality and coverage of all targets using a minimal number of sensors. The system ensures the visibility of targets between PTZ cameras by using criteria such as distance from sensor and occlusion.
Cell cycle analysis and X-chromosome inactivation in the developing mouse. (1976)

The duration of different phases of the cell cycle (G1, S, G2, and M), as well as the exact time of initiation of asynchronous DNA replication pattern in one of the X-chromosomes in the female mouse during the early stages of development, have been investigated. It was found that early developmental stages in the mouse are devoid of G1 period, and from the late blastocyst stage the embryonic cells first acquire all the characteristic stages of the cell cycle (G1, S, G2, and M). Additionally, asynchronous DNA replication pattern in one of the X-chromosomes in the female embryos was found to be initiated with the appearance of the G1 period. I have established a correlation between the onset of the G1 period and the initiation of an asynchronous DNA replication pattern in one of the X-chromosomes of the female mammal during embryogenesis.
Energy from the water cycle: a promising combination to operate climate neutral (2011)

Waternet, the first water cycle company in the Netherlands, is responsible for drinking water treatment and distribution, wastewater collection and treatment, and watersystem management and control in and around Amsterdam. Waternet has the ambition to operate climate neutral in 2020. To realise this ambition, measures are required to compensate for the emission of 53,000 ton CO2-eq/year. Energy recovery from the water cycle looks very promising. From wastewater, ground water, surface water and drinking water, all elements of the water cycle, renewable energy can be recoverd. This can be thermal energy and chemical energy. First calculations reveal that energy recovery from the water cycle in and around Amsterdam can contribute to a total reduction in green house gas emissions up to 148,000 ton CO2-eq/year. The challenge for the coming years is to choose robust combinations of all the possibilities to fulfil the energy demand at any time. Only then the use of fossil fuel can be abandoned and the target of operating climate neutral in 2020 can be reached.
Hybrid Polymer Electrolyte Fuel Cells: Alkaline Electrodes with Proton Conducting Membrane (2010)

Smart management: A new hybrid fuel-cell configuration (see picture) exploits the stability and high ionic conductivity of proton-exchange materials (PEM) and electrochemical advantages of anion-exchange membrane (AEM) electrodes. Water management is significantly improved compared to traditional polymer electrolyte membrane fuel cells, allowing self-humidification of the cell. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Low-Dose Quetiapine Fumarate (50 mg) for Obsessive-Compulsive Disorder Patients With Comorbid Bipolar Depression (2021)

Department of acute admissions, Ma'ale HaCarmel Mental Health Center, Tiral Carmel, Israel; Department of Psychiatry, Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel [email protected] Geha Research Unit, Felsenstein Medical Research Laboratory, Petach Tikva, Israel; Department of Psychiatry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.
Versatile Manipulation of Viruses in All-Dielectric Optofluidic Nanocavity Arrays (2021)

We develop a nano-optofluidic chip with an all-dielectric nanocavity array for versatile manipulation of single or massive adenoviruses. Viruses can be transported, sorted, and concentrated using the trapping mode where light is trapped inside nanoholes.
TokenSmart: Distributed, Scalable Power Management in the Many-Core Era (2021)

Centralized power management control systems are hitting a scalability limit. In particular, enforcing a power cap in a many-core system in a performance-friendly manner is quite challenging. Today's on-chip controller reduces the clock speed of compute domains in response to local or global power limit alerts. However, this is transparent to the operating system (OS), which continues to request higher clock frequency based on the workload characteristics acting against the centralized on chip controller. To address these issues, we introduce TokenSmart, which implements a scalable distributed frequency control heuristics within the OS, using a novel token-based mechanism. The compute units are connected in a ring-topology allowing minimal meta-data to be passed along with the token value for regulating power budget. We explore different heuristics to assign tokens smartly across the units. This results in efficient power regulation and sustenance of turbo frequencies over a longer duration. The methodology is implemented within the Linux kernel of a real IBM POWER9 many-core system. The experimental results show a considerable boost of about 4 percent in throughput of PostgreSQL benchmark with a tangible 18 percent decrease in power consumption.
Revision Total Shoulder Arthroplasty for the Treatment of Glenoid Arthrosis* (1998)

The development of painful glenoid arthrosis is the most common reason for reoperation after replacement of the humeral head. We performed twenty-two revision total shoulder arthroplasties, between 1983 and 1992, for the treatment of painful glenoid arthrosis in shoulders that had a prosthetic replacement of the humeral head. Eighteen shoulders (seventeen patients) were included in the study as their preoperative and operative records were complete and they had been followed for at least two years (mean, 5.5 years; range, 2.3 to 10.0 years). The indications for the hemiarthroplasty were trauma (ten shoulders), osteoarthrosis (four), rheumatoid arthritis (two), and osteonecrosis secondary to the use of steroids (two). The mean interval between the hemiarthroplasty and the total shoulder replacement was 4.4 years (range, 0.8 to 12.7 years). The mean score for pain in the shoulder decreased from 4.3 points before the revision to 2.2 points after it (p = 0.0001). The mean active abduction increased from 94 degrees before the revision to 124 degrees after it (p = 0.01), and the mean external rotation increased from 32 to 58 degrees (p = 0.007). Two shoulders needed another operation after the revision because of a late infection in one and particulate synovitis associated with instability in the other. With the numbers available for study, we did not detect a significant difference in pain relief and range of motion with respect to gender, diagnosis, subluxation, or the presence of periprosthetic radiolucency. Our findings indicate that most patients with painful glenoid arthrosis after a hemiarthroplasty have marked pain relief and improvement in motion after revision to a total shoulder replacement. However, seven of the eighteen shoulders that had this procedure had an unsatisfactory result due to a limited range of motion or the need for a subsequent operation. Therefore, long-term studies are necessary to evaluate the durability of total shoulder replacement in this group of patients.
Functional Evaluation of Hemoglobin- and Lipidheme‐vesicles as Red Cell Substitutes (1996)

The two kinds of red cell substitutes, hemoglobin-vesicles (HbV) and lipidheme-vesicles (LihV, totally synthetic oxygen carrier), were evaluated in terms of physicochemical properties such as binding and dissociating reactions of ligands (CO, O2 and NO), rheological and structural properties. Carbonylation of Hb during the purification of Hb and the preparation of HbV is effective to prevent Hb denaturation. The rates of oxygenation of both HbV and LihV are faster than that of red blood cells (RBC). Their oxygen affinities (P50, HbV, 32 mmHg; LihV, 43 mmHg, cf. RBC, 28 mmHg) can be controlled to transport a sufficient amount of oxygen comparable with that of RBC. The smaller sizes of vesicles are advantageous for prompt ligand reaction and low viscosity. Both HbV and RBC show about 100 times less vasoconstrictive effects than stripped Hb. HbV shows only one sixth of the slow binding rate of NO (=endothelial derived relaxation factor) in comparison with stripped Hb. Inhibition of vasoconstriction by those vesicles is discussed from the kinetic data.
Extrusion de supports de catalyseurs : Le problème de la caractérisation rhéologique des pâtes fortement chargées (2000)

International audience
Selective and Efficient Biomacromolecular Extraction of Rare-Earth Elements using Lanmodulin (2020)

Lanmodulin (LanM) is a recently discovered protein that undergoes a large conformational change in response to rare-earth elements (REEs). Here, we use multiple physicochemical methods to demonstrate that LanM is the most selective macromolecule for REEs characterized to date and even outperforms many synthetic chelators. Moreover, LanM exhibits metal-binding properties and structural stability unseen in most other metalloproteins. LanM retains REE binding down to pH ≈ 2.5, and LanM-REE complexes withstand high temperature (up to 95 °C), repeated acid treatments, and up to molar amounts of competing non-REE metal ions (including Mg, Ca, Zn, and Cu), allowing the protein's use in harsh chemical processes. LanM's unrivaled properties were applied to metal extraction from two distinct REE-containing industrial feedstocks covering a broad range of REE and non-REE concentrations, namely, precombustion coal and electronic waste leachates. After only a single all-aqueous step, quantitative and selective recovery of the REEs from all non-REEs initially present (Li, Na, Mg, Ca, Sr, Al, Si, Mn, Fe, Co, Ni, Cu, Zn, and U) was achieved, demonstrating the universal selectivity of LanM for REEs against non-REEs and its potential application even for industrial low-grade sources, which are currently underutilized. Our work indicates that biosourced macromolecules such as LanM may offer a new paradigm for extractive metallurgy and other applications involving f-elements.
Bacteriorhodopsin induces a light-scattering change in Halobacterium halobium. (1978)

When suspensions of Halobacterium halobium are exposed to bright light, the light-scattering properties of the bacteria change. This light-scattering response can produce a transmission decrease of about 1% throughout the red and near-infrared region. The action spectrum for the light-scattering response appropriately matches the absorption spectrum of bacteriorhodopsin. The response is eliminated by cyanide p-trifluoro-methoxyphenylhydrazone, a proton ionophore, and by triphenylmethylphosphonium, a membrane permanent cation. A mild hypertonic shock induces a similar light-scattering change, suggesting that bright light causes the bacteria to shrink about 1% in volume, thereby producing the light-scattering response.