gebhart/patrepeval huggingface dataset:
Anti-Spike, anti-Nucleocapsid and neutralizing antibodies in SARS-CoV-2 inpatients and asymptomatic carriers (2020)

Summary Objective The objective of this study was to monitor the anti-SARS-CoV-2 antibody response in infected patients. Methods In order to assess the time of seroconversion, we used 151 samples from 30 COVID-19 inpatients and monitored the detection kinetics of anti-S1, anti-S2, anti-RBD and anti-N antibodies with in-house ELISAs. We also monitored the presence of neutralizing antibodies in these samples as well as 25 asymptomatic carrier samples using retroviral particles pseudotyped with the spike of the SARS-CoV-2. Results We observed that specific antibodies were detectable in all inpatients two weeks post-symptom onset. The detection of the SARS-CoV-2 Nucleocapsid and RBD was more sensitive than the detection of the S1 or S2 subunits. Neutralizing antibodies reached a plateau two weeks post-symptom onset and then declined in the majority of inpatients. Furthermore, neutralizing antibodies were undetectable in 56% of asymptomatic carriers. Conclusions Our results raise questions concerning the role played by neutralizing antibodies in COVID-19 cure and protection against secondary infection. They also suggest that induction of neutralizing antibodies is not the only strategy to adopt for the development of a vaccine. Finally, they imply that anti-SARS-CoV-2 neutralizing antibodies should be titrated to optimize convalescent plasma therapy. Highlights Specific antibodies are detectable in 100% COVID-19 inpatients two weeks post-symptom onset. The detection of the SARS-CoV-2 Nucleocapsid and Receptor Binding Domain is more sensitive than the detection of the S1 or S2 subunits. Neutralizing antibodies reach a plateau two weeks post-symptom onset and then decline in the majority of inpatients. Neutralizing antibodies are undetectable in the majority of asymptomatic carriers.
Extramediastinal surgical problems in heart transplant recipients (1999)

Extramediastinal diseases after heart transplantation involve most surgical specialties. Most of them are potentially linked with either the immunosuppressive therapy or the transplantation procedure, supporting our low-level immunosuppression policy. Expectant management is not justified in this population, who withstands operations well both early and late after transplantation.
Highly efficient femtosecond pulse stretching by tailoring cavity dispersion in erbium fiber lasers with an intracavity short-pass edge filter (2011)

We demonstrate highly efficient pulse stretching in Er(3+)-doped femtosecond mode-locked fiber lasers by tailoring cavity dispersion using an intracavity short-pass edge filter. The cavity dispersion is preset at around zero to obtain the shortest pulsewidth. When the cutoff wavelength of the short-pass edge filter is thermo-optically tuned to overlap the constituting spectral components of mode-locked pulses, large negative waveguide dispersion is introduced by the steep cutoff slope and the total cavity dispersion is moved to normal dispersion regime to broaden the pulsewidth. The time-bandwidth product of the mode-locked pulse increases with the decreasing temperature at the optical liquid surrounding the short-pass edge filter. Pulse stretch ratio of 3.53 (623.8 fs/176.8 fs) can be efficiently achieved under a temperature variation of 4 °C.
Identification of a protein of 15,000 daltons related to isoleucine-valine biosynthesis in Escherichia coli K-12 (1982)

The effect of the ilvG671, ilvG468, and ilvG603 mutations (phenotype, IlvG+ Valr; formerly ilvO) upon proteins synthesized was determined by infection of irradiated Escherichia coli K-12 cells, using specifically constructed derivatives of lambda dilv phage. These ilvG alleles are similar to the previously studied ilvG2096(Valr) allele in that they activate the latent ilvG gene which is present in the wild-type strain, leading to the synthesis of a 62,000-dalton protein. In addition, all of these ilvG (Valr) alleles increase the synthesis of a 15,000-dalton protein. To localize the gene coding for the 15,000-dalton protein, the proteins produced in maxicells containing plasmids with specific deletions of ilv and rrnX DNA segments were analyzed. The gene coding for the 15,000-dalton protein was located within a region about 1,000 base pairs long between ilv and trpT. The function of the 15,000-dalton protein is not known.
A New Porous Lithosilicate with a High Ionic Conductivity and Ion-Exchange Capacity (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Porous Lithosilicate with a High Ionic Conductivity and Ion-Exchange CapacitySo-Hyun Park, John B. Parise, Hermann Gies, Haiming Liu, Clare P. Grey, and Brian H. TobyView Author Information Department of Geosciences State University of New York at Stony Brook Stony Brook, New York 11790-2100 Cite this: J. Am. Chem. Soc. 2000, 122, 44, 11023–11024Publication Date (Web):October 24, 2000Publication History Received16 August 2000Published online24 October 2000Published inissue 1 November 2000https://pubs.acs.org/doi/10.1021/ja005527qhttps://doi.org/10.1021/ja005527qrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views441Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Cations,Chemical structure,Electrical conductivity,Ionic conductivity,Materials Get e-Alerts
Receipts2Go (2012)

The Receipts2Go system is about the world of one-page documents: cash register receipts, book covers, cereal boxes, price tags, train tickets, fire extinguisher tags. In that world, we're exploring techniques for extracting accurate information from documents for which we have no layout descriptions -- indeed no initial idea of what the document's genre is -- using photos taken with cell phone cameras by users who aren't skilled document capture technicians. This paper outlines the system and reports on some initial results, including the algorithms we've found useful for cleaning up those document images, and the techniques used to extract and organize relevant information from thousands of similar-but-different page layouts.
Latarjet-Bristow Procedure Performed With Bioabsorbable Screws (2010)

The Latarjet-Bristow procedure has been shown to be a safe and reliable method of treating recurrent anterior instability. We proposed using bioabsorbable screws for fixation of the coracoid graft to avoid the potential complications associated with metallic hardware. The aim of this study was to assess the early radiologic healing of the graft using bioabsorbable screws and comment on our initial experience using this method of fixation for the Latarjet-Bristow procedure. Twelve Latarjet-Bristow procedures were performed for recurrent anterior instability using two 4.5-mm bioabsorbable compression screws composed of L-lactic/co-glycolic acid copolymer (PLGA 85L/15G). All patients had follow-up imaging including plain radiographs and a computed tomography scan performed at 3 months postoperatively to assess bone healing and graft position. In all cases, there was radiologic evidence of bony graft healing in a satisfactory position. There were no intraoperative or postoperative complications observed. This study confirms that satisfactory bone healing in the Latarjet-Bristow procedure can be obtained with the use of bioabsorbable screws. Although the early radiographic results were encouraging, at this stage, we cannot recommend the use of bioabsorbable screws for use with the Latarjet-Bristow procedure until the long-term clinical and radiologic outcomes are assessed. Level of Evidence Case series (IV).
Hommage à Jean Dausset (1916-2009) (2010)

Jean Dausset nous a quittés le 6 juin 2009 à l’âge de 93 ans. Titulaire de la chaire de Médecine expérimentale de 1977 à 1987, il fut à l’origine d’une des découvertes les plus importantes jamais faites en immunologie : celle du système HLA. En 1952, il observe que le mélange de globules blancs d’un malade avec le sérum d’un autre donneur provoque une réaction d’agglutination. Il en déduit qu’il existe dans ce dernier des anticorps anti-globules blancs et montre que ceux-ci sont le résultat d...
Constrained Wiener gains and filters for single-channel and multichannel noise reduction (2016)

Noise reduction has long been an active research topic in signal processing and many algorithms have been developed over the last four decades. These algorithms were proved to be successful in some degree to improve the signal-to-noise ratio (SNR) and speech quality. However, there is one problem common to all these algorithms: the volume of the enhanced signal after noise reduction is often perceived lower than that of the original signal. This phenomenon is particularly serious when SNR is low. In this paper, we develop two constrained Wiener gains and filters for noise reduction in the short-time Fourier transform (STFT) domain. These Wiener gains and filters are deduced by minimizing the mean-squared error (MSE) between the clean speech and the speech estimate with the constraint that the sum of the variances of the filtered speech and residual noise is equal to the variance of the noisy observation.
Muscle‐derived Stem Cell Therapy for Stress Urinary Incontinence (2009)

The aim of the present article is to overview the potential of muscle‐derived stem cells and other cellular therapy for urethral regeneration and to review the clinical experiences of its application in patients with stress urinary incontinence.
Pd(II)-Catalyzed Chemoselective Acetoxylation of C(sp2)–H and C(sp3)–H Bonds in Tertiary Amides (2021)

Palladium-catalyzed chemoselective C(sp<sup>2</sup>)-H and C(sp<sup>3</sup>)-H acetoxylation of synthetically useful tertiary amides is reported under relatively mild reaction conditions. This protocol proceeds through the assistance of a weakly coordinated directing group (C═O) and requires low catalyst (1.0 mol %) loading. Diverse functionalities, such as C(sp<sup>2</sup>)-Cl, C(sp<sup>3</sup>)-Cl, -CF<sub>3</sub>, -COOEt, and -NO<sub>2</sub> groups, including morpholinyl, piperazinyl, and pyrrolidinyl heterocycles, are compatible under the reaction conditions. Further functionalization of this protocol is demonstrated by hydrolysis to alcohols, alcohol-acids, as well as reduction to tertiary amines. A preliminary kinetic isotope effect study supported the rate-limiting C-H bond activation process.
V H replacement in primary immunoglobulin repertoire diversification (2015)

The genes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (diversity), and J (joining) elements through a RAG-mediated recombination process that relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements. Secondary V(D)J rearrangement modifies the original Ig rearrangement if a nonproductive original joint is formed, as a response to inappropriate signaling from a self-reactive BCR, or as part of a stochastic mechanism to further diversify the Ig repertoire. VH replacement represents a RAG-mediated secondary rearrangement in which an upstream VH element recombines with a rearranged VHDHJH joint to generate a new BCR specificity. The rearrangement occurs between the cryptic RSS of the original VH element and the conventional RSS of the invading VH gene, leaving behind a footprint of up to five base pairs (bps) of the original VH gene that is often further obscured by exonuclease activity and N-nucleotide addition. We have previously demonstrated that VH replacement can efficiently rescue the development of B cells that have acquired two nonproductive heavy chain (IgH) rearrangements. Here we describe a novel knock-in mouse model in which the prerearranged IgH locus resembles an endogenously rearranged productive VHDHJH allele. Using this mouse model, we characterized the role of VH replacement in the diversification of the primary Ig repertoire through the modification of productive VHDHJH rearrangements. Our results indicate that VH replacement occurs before Ig light chain rearrangement and thus is not involved in the editing of self-reactive antibodies.
Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (2018)

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT is characterized by a diploid genome with loss of SMARCA4 and lack of SMARCA2 expression, two mutually exclusive ATPases of the SWI/SNF chromatin-remodeling complex. We and others have identified the histone methyltransferase EZH2 as a promising therapeutic target for SCCOHT, suggesting that SCCOHT cells depend on the alternation of epigenetic pathways for survival. In this study, we found that SCCOHT cells were more sensitive to pan-HDAC inhibitors compared with other ovarian cancer lines or immortalized cell lines tested. Pan-HDAC inhibitors, such as quisinostat, reversed the expression of a group of proteins that were deregulated in SCCOHT cells due to SMARCA4 loss, leading to growth arrest, apoptosis, and differentiation <i>in vitro</i> and suppressed tumor growth of xenografted tumors of SCCOHT cells. Moreover, combined treatment of HDAC inhibitors and EZH2 inhibitors at sublethal doses synergistically induced histone H3K27 acetylation and target gene expression, leading to rapid induction of apoptosis and growth suppression of SCCOHT cells and xenografted tumors. Therefore, our preclinical study highlighted the therapeutic potential of combined treatment of HDAC inhibitors with EZH2 catalytic inhibitors to treat SCCOHT.
Urban tribes: Analyzing group photos from a social perspective (2012)

The explosive growth in image sharing via social networks has produced exciting opportunities for the computer vision community in areas including face, text, product and scene recognition. In this work we turn our attention to group photos of people and ask the question: what can we determine about the social subculture or urban tribe to which these people belong? To this end, we propose a framework employing low- and mid-level features to capture the visual attributes distinctive to a variety of urban tribes. We proceed in a semi-supervised manner, employing a metric that allows us to extrapolate from a small number of pairwise image similarities to induce a set of groups that visually correspond to familiar urban tribes such as biker, hipster or goth. Automatic recognition of such information in group photos offers the potential to improve recommendation services, context sensitive advertising and other social analysis applications. We present promising preliminary experimental results that demonstrate our ability to categorize group photos in a socially meaningful manner.
Vacuum-UV-excited Photoluminescence and Scintillation Properties of CsCl Transparent Ceramics and Single Crystal (2019)

CsCl transparent ceramics were prepared by the spark plasma sintering (SPS) method, and their optical, scintillation, and dosimetric properties were investigated. To evaluate the potential of the transparent ceramics, a CsCl single crystal was prepared by the vertical Bridgman-Stockbarger method. Regarding the luminescence properties, the vacuum UV (VUV)-excited photoluminescence (PL) and scintillation spectral features of the transparent ceramics were similar to those of the single crystal. Concerning the thermally stimulated luminescence (TSL) properties, the minimum detection limit of the transparent ceramics was 0.01 mGy.
Measurement of Promptψ(2S)toJ/ψYield Ratios in Pb-Pb andp-pCollisions atsNN=2.76  TeV (2014)

The ratio between the prompt ψ(2S) and J/ψ yields, reconstructed via their decays into μ+ μ-, is measured in Pb-Pb and p-p collisions at sqrt[sNN]=2.76 TeV. The analysis is based on Pb-Pb and p-p data samples collected by CMS at the Large Hadron Collider, corresponding to integrated luminosities of 150 μb(-1) and 5.4 pb(-1), respectively. The double ratio of measured yields (Nψ(2S)/N(J/ψ))(Pb-Pb)/(Nψ(2S)/N(J/ψ))(p-p) is computed in three Pb-Pb collision centrality bins and two kinematic ranges: one at midrapidity, |y|<1.6, covering the transverse momentum range 6.5<pT<30 GeV/c, and the other at forward rapidity, 1.6<|y|<2.4, extending to lower pT values, 3<pT<30 GeV/c. The centrality-integrated double ratio changes from 0.45±0.13(stat)±0.07(syst) in the first range to 1.67±0.34(stat)±0.27(syst) in the second. This difference is most pronounced in the most central collisions.
Toward a holistic federated future internet experimentation environment: the experience of NOVI research and experimentation (2015)

This article presents the design and pilot implementation of a suite of intelligent methods, algorithms, and tools for federating heterogeneous experimental platforms (domains) toward a holistic Future Internet experimentation ecosystem. The proposed framework developed within the NOVI research and experimentation European collaborative effort, aims at providing a modular data, control, and management plane architecture that includes: an information model capturing the abstractions of virtualized resources residing in different yet interworking experimental platforms; resource mapping algorithms tackling the inter-domain virtual network embedding problem; mechanisms providing interoperability of monitoring tools; policy-based management services for role-based intra and inter-domain management policies; and dataplane stitching mechanisms to enable the composition of user-specific slices (baskets of virtual resources drawn from the federated substrate). The NOVI framework was deployed and validated in a combined testbed consisting of two dissimilar platforms: a private PlanetLab domain with resources interconnected over the public Internet; and FEDERICA, an infrastructure of virtual resources interconnected via dedicated networking facilities of European National Research and Education Networks and GÉANT. This pre-normative work is expected to contribute to bridging Future Internet experimental federations with interconnected cloud architectures and interworked public/private data-centers, adding value via its intelligent services, information models, and composite algorithms.
Effect of early enteral nutrition after hepatectomy in hepatocellular carcinoma patients (2012)

ED group had no difference in nutritional recovery and postoperative complication rates compared to CD group but it has better gastrointestinal motility recovery, liver function recovery, and shorter postoperative admission days.
Parametric amplification of 100 fs mid-infrared pulses in ZnGeP_2 driven by a Ho:YAG chirped-pulse amplifier (2017)

We report on the parametric generation of 100 fs sub-6-cycle 40 μJ pulses with the center wavelength at 5.2 μm using a 1 ps 2.1 μm pump laser and a dispersion management scheme based on bulk material. Our optically synchronized amplifier chain consists of a Ho:YAG chirped-pulse amplifier and white-light-seeded optical parametric amplifiers providing simultaneous passive carrier-envelope phase locking of three ultrashort longwave pulses at the pump, signal, and idler wavelengths corresponding, respectively, to 2.1, 3.5, and 5.2 μm. We also demonstrate bandwidth enhancement and efficient control over nonlinear spectral phase in the regime of cascaded χ<sup>2</sup> nonlinearity in ZnGeP<sub>2</sub>.
Exploring Non‐obvious Hydrophobic Binding Pockets on Protein Surfaces: Increasing Affinities in Peptide–Protein Interactions (2017)

A 42-residue polypeptide conjugated to a small-molecule organic ligand capable of targeting the phosphorylated side chain of Ser15 was shown to bind glycogen phosphorylase a (GPa) with a K<sub>D</sub> value of 280 nm. The replacement of hydrophobic amino acids by Ala reduced affinities, whereas the incorporation of l-2-aminooctanoic acid (Aoc) increased them. Replacing Nle5, Ile9 and Leu12 by Aoc reduced the K<sub>D</sub> value from 280 to 27 nm. "Downsizing" the 42-mer to an undecamer gave rise to an affinity for GPa an order of magnitude lower, but the undecamer in which Nle5, Ile9 and Leu12 were replaced by Aoc showed a K<sub>D</sub> value of 550 nm, comparable with that of the parent 42-mer. The use of Aoc residues offers a convenient route to increased affinity in protein recognition as well as a strategy for the "downsizing" of peptides essentially without loss of affinity. The results show that hydrophobic binding sites can be found on protein surfaces by comparing the affinities of polypeptide conjugates in which Aoc residues replace Nle, Ile, Leu or Phe with those of their unmodified counterparts. Polypeptide conjugates thus provide valuable opportunities for the optimization of peptides and small organic compounds in biotechnology and biomedicine.
An Efficient Coverage Algorithm for Intelligent Robots with Deadline (2009)

이 논문은 지능형 로봇을 위한 새로운 커버리지 알고리즘을 제안한다. 커버리지 알고리즘의 성능을 향상하기 위한 많은 연구들은 전체 커버리지 완료 시간을 최소화하는데 초점을 맞추어왔다. 그러나, 만일 전체 커버리지를 완료하기에 충분한 시간이 없다면, 최적의 경로는 달라질 수 있다. 이러한 문제를 해결하기 위하여 본 논문에서는 MaxCoverage라고 하는 데드라인이 있을 경우에 가능한 많은 면적을 커버하기 위한 새로운 커버리지 알고리즘을 제안한다. MaxCoverage 알고리즘은 이동 경로를 셋 커버 문제를 위한 그리디 알고리즘을 이용하여 결정한다. 실험 결과에 의하면 MaxCoverage 알고리즘은 임의의 데드라인에 대하여 다른 알고리즘들에 비해 향상된 성능을 보여준다. This paper proposes a new coverage algorithm for intelligent robot. Many algorithms for improving the performance of coverage have been focused on minimizing the total coverage completion time. However, if one does not have enough time to finish the whole coverage, the optimal path could be different. To tackle this problem, we propose a new coverage algorithm, which we call MaxCoverage algorithm, for covering maximal area within the deadline. The MaxCoverage algorithm decides the navigation flow by greedy algorithm for Set Covering Problem. The experimental results show that the MaxCoverage algorithm performs better than other algorithms for random deadlines.