gebhart/patrepeval huggingface dataset:
Pigs, Dogs, Baboons, and Man: Lessons for Stenting from Animal Studies (1994)

A new era in interventional cardiology has arrived with the widespread use of intracoronary stents. These devices have not only markedly improved the safety of dilatation, but have also limited restenosis through achievement of a larger postprocedure lumen. Much work remains in furthering this technology, since two major limitations are thrombosis and neointimal hyperplasia that still cause restenosis. Stent placement in animals provides insight into both of these areas. The volume of neointima is directly proportional to the depth of injury induced by the stent in at least three species: the pig, baboon, and dog. Across each species, a numerically different slope exists for the injury‐neointimal thickness regression. Treatments to limit hyperplasia within a species do not change this slope, but instead alter the y‐intercept. Stent thrombosis in animal models consists principally of platelet‐rich thrombi. The time course of thrombus appears to differ across pigs and baboons. Antiplatelet agents limit, but do not eliminate the problem in animals, suggesting that newer and more potent antiplatelet agents may improve scent thrombosis in clinical trials. The future of stent technology lies in developing an antithrombotic device that also eliminates neointimal hyperplasia. Intense studies of animal models and improved understanding of their pathophysiology will facilitate this progress.
WeECG: a low-cost real-time wireless ECG for new born monitoring with error concealment (2023)

This work designs a low-cost wireless HR monitoring device, WeECG, that also stores the data for subsequent analysis. Additional important design requirements include ease of use, baby comfort, support for mobility while insuring also a high level of signal integrity. We first developed a client server architecture using off-the-shelf components and a smartphone running the Android operating system. During the development of the communication module, we tested and compared two separate communication technologies: a popular ultra-low power wireless transceiver with embedded base-band protocols and a BLE communication module. WeECG presented a smaller measurement error when compared with the palpation method and a standard deviation of 0.4069 BPM when the peak interval algorithm was applied. We also examined packet loss and developed strategies to mitigate its effect, making it possible to safely transmit ECG signals. Finally, we also analyse the solution in terms of cost, size and energy consumption.
A visual model for optimizing the design of image processing algorithms (2002)

The paper describes an algorithm for the assessment of image fidelity. The algorithm includes an image processing model of the human visual system for luminance still imagery. The major components of the algorithm are described that model the visual system as three main sensitivity variations. These address the sensitivity as a function of gray level, as a function of spatial frequency, and as a function of image content. To quantify the performance of the algorithm, specific psychophysical experiments were simulated, and these results are shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
HybridSDF: Combining Deep Implicit Shapes and Geometric Primitives for 3D Shape Representation and Manipulation (2021)

Deep implicit surfaces excel at modeling generic shapes but do not always capture the regularities present in manufactured objects, which is something simple geometric primitives are particularly good at. In this paper, we propose a representation combining latent and explicit parameters that can be decoded into a set of deep implicit and geometric shapes that are consistent with each other. As a result, we can effectively model both complex and highly regular shapes that coexist in manufactured objects. This enables our approach to manipulate 3D shapes in an efficient and precise manner.
A high‐oleic‐acid and low‐palmitic‐acid soybean: agronomic performance and evaluation as a feedstock for biodiesel (2009)

Phenotypic characterization of soybean event 335-13, which possesses oil with an increased oleic acid content (> 85%) and reduced palmitic acid content (< 5%), was conducted across multiple environments during 2004 and 2005. Under these conditions, the stability of the novel fatty acid profile of the oil was not influenced by environment. Importantly, the novel soybean event 335-13 was not compromised in yield in both irrigated and non-irrigated production schemes. Moreover, seed characteristics, including total oil and protein, as well as amino acid profile, were not altered as a result of the large shift in the fatty acid profile. The novel oil trait was inherited in a simple Mendelian fashion. The event 335-13 was also evaluated as a feedstock for biodiesel. Extruded oil from event 335-13 produced a biodiesel with improved cold flow and enhanced oxidative stability, two critical fuel parameters that can limit the utility of this renewable transportation fuel.
A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies (2006)

We are studying an antagonist of the SDF-1/CXCR4 interaction, AMD3100, as a single agent to procure mobilized blood from allogeneic donors. Eleven HLA identical siblings received one or two doses of AMD3100 at 240 μg/kg subcutaneously followed in four hours by leukapheresis (LP). After successful collection and a one week washout period, the same donors were remobilized using a standard G-CSF dose and schedule. AMD3100 administration resulted in a median 7-fold increase in peripheral CD34+ cell count from baseline within 4-6 hours compared to 21-fold after five days of G-CSF. Nine of eleven donors mobilized following AMD3100 collected at least 1.9 × 106 CD34+ cells/kg recipient weight following 1 (n = 5) or 2 (n = 4) LP procedures. Allografts mobilized following AMD3100 contained less CD34+ cells but proportionately greater numbers of T-,B-, and NK-cells compared to G-CSF allografts. AMD3100 was well tolerated and no donors experienced any greater than grade 1 toxicity. One donor could not tolerate apheresis and was taken off study. Eight patients have been transplanted using the AMD3100 mobilized allografts. Two patients did not receive allografts due to progressive disease. The median age of the recipients was 45 years (range 32-53). Three had AML, one ALL, one CLL, one accelerated CML, and two non-Hodgkin’s lymphoma. With a median follow-up of 290 days (range 75 to 486 days), all eight evaluable pts have engrafted neutrophils >500/μl at a median of 10 days (range 8-13) and platelets >20000/μl at a median of 19 days (range 15-25). Acute GVHD prophylaxis employed single agent cyclosporine only. One of eight patients to date has experienced grade 2-4 acute GVHD, and that pt expired due to refractory GVHD. Two of five evaluable patients have experienced extensive chronic GVHD requiring immunosuppressive therapy. All pts achieved early full donor chimerism of peripheral T- and myeloid cell compartments which has been sustained. Seven of the eight pts currently survive progression free with full trilineage hematopoiesis. In summary, grafts mobilized following AMD3100 differ from G-CSF mobilized allografts in the content of CD34+ and immune effector cells yet appear to reconstitute hematopoiesis similarly. The risk of acute GVHD does not seem to be increased despite the transplantation of higher T-cell doses. It appears that a chemokine antagonist given alone can safely and rapidly induce the mobilization of a functionally competent hematopoietic allograft.
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects (2002)

The subtilisin-like proprotein convertases PC1/3 (SPC3) and PC2 (SPC2) are believed to be the major endoproteolytic processing enzymes of the regulated secretory pathway. They are expressed together or separately in neuroendocrine cells throughout the brain and dispersed endocrine system in both vertebrates and invertebrates. Disruption of the gene-encoding mouse PC1/3 has now been accomplished and results in a syndrome of severe postnatal growth impairment and multiple defects in processing many hormone precursors, including hypothalamic growth hormone-releasing hormone (GHRH), pituitary proopiomelanocortin to adrenocorticotropic hormone, islet proinsulin to insulin and intestinal proglucagon to glucagon-like peptide-1 and -2. Mice lacking PC1/3 are normal at birth, but fail to grow normally and are about 60% of normal size at 10 weeks. They lack mature GHRH, have low pituitary growth hormone (GH) and hepatic insulin-like growth factor-1 mRNA levels and resemble phenotypically the "little" mouse (Gaylinn, B. D., Dealmeida, V. I., Lyons, C. E., Jr., Wu, K. C., Mayo, K. E. & Thorner, M. O. (1999) Endocrinology 140, 5066-5074) that has a mutant GHRH receptor. Despite a severe defect in pituitary proopiomelanocortin processing to mature adrenocorticotropic hormone, blood corticosterone levels are essentially normal. There is marked hyperproinsulinemia but without impairment of glucose tolerance. In contrast, PC2-null mice lack mature glucagon and are chronically hypoglycemic (Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, J., Carroll, R., Ravazzola, M., Orci, L., Furuta, H. & Steiner, D. (1997) Proc. Natl. Acad. Sci. USA 94, 6646-6651). The PC1/3-null mice differ from a human subject reported with compound heterozygosity for defects in this gene, who was of normal stature but markedly obese from early life. The PC1/3-null mice are not obese. The basis for these phenotypic differences is an interesting topic for further study. These findings prove the importance of PC1/3 as a key neuroendocrine convertase.
Supplementary Table 1 from A First-Generation Multiplex Biomarker Analysis of Urine for the Early Detection of Prostate Cancer (2023)

Supplementary Table 1 from A First-Generation Multiplex Biomarker Analysis of Urine for the Early Detection of Prostate Cancer
A feed restriction milieu for Pekin meat ducks that may improve gait characteristics but also affects gut leakiness (2019)

In a previous study, we demonstrated that a 15% feed restriction (FR) during the first 2 wk after hatch could improve gait in Pekin meat ducks, but did result in reduced breast mass. We hypothesized that feed restriction after day 5 following muscle satellite cell development would allow the full growth of the breast meat. To accomplish this goal, 300 1-day-old ducklings (Maple Leaf Farms Inc.) were randomly allocated to 1 of the 3 groups (n = 4 pens, 25 ducks per pen): (1) Control group fed to ad libitum; (2) 85% daily feed intake from days 1 to 14 (FR 85% 1-14); 85% daily feed intake from days 5 to 14 (FR 85% 5-14). All ducks were vaccinated with inactivated Salmonella enteritidis on day 14 and boosted on day 26. The FR 85% 5-14 did show similar production standards to controls, and improved gait characteristics (P < 0.05). To determine if the partial feed restriction would have an impact on intestinal epithelial tight junction integrity, we treated ducks on days 7, 14, 21, 28, and 35 with 8.32 mg/kg FITC-d in water per os and blood samples were obtained via the tibial vein 1 h later. Serum samples were analyzed for presence and quantification of FITC-d. Feed restriction elicited a significant increase in FITC-d permeability at all points of evaluation. Anti-S. enteritidis specific IgY responses were assessed by ELISA from serum collected at 14 D, 28 D, and 35 D. Although all ducks showed an increase humoral immune response to the S. enteritidis, both feed restricted groups showed reduced IgY production compared to ad lib controls. Our data suggest that although the FR 5-14 feed restriction paradigm may reduce gait abnormalities without affecting production rates, some challenges exist due to increased gut leakiness or decreased acquired immune activity. Future studies will look at altering the feed restriction milieu to ameliorate these challenges.
Mapping of Amino Acid Substitutions Conferring Herbicide Resistance in Wheat Glutathione Transferase (2014)

We have used design of experiments (DOE) and systematic variance to efficiently explore glutathione transferase substrate specificities caused by amino acid substitutions. Amino acid substitutions selected using phylogenetic analysis were synthetically combined using a DOE design to create an information-rich set of gene variants, termed infologs. We used machine learning to identify and quantify protein sequence-function relationships against 14 different substrates. The resulting models were quantitative and predictive, serving as a guide for engineering of glutathione transferase activity toward a diverse set of herbicides. Predictive quantitative models like those presented here have broad applicability for bioengineering.
Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas (2021)

Paragangliomas are rare neuroendocrine tumors that can vary in size and metabolic activity. We report a case of giant bilateral malignant retroperitoneal paragangliomas (PGL) in a patient with germline succinate dehydrogenase B (SDHB) mutation. This patient, who presented in an emaciated and debilitated state, was managed with adrenergic blockade followed by radical primary surgery. After being metabolically and radiographically disease free for 4 years, he underwent salvage resection for recurrent retroperitoneal disease and palliative radiation to a site of solidary vertebral metastasis. We review incidence and prognosis of metastatic PGL.
A novel structured sparse fully connected layer in convolutional neural networks (2021)

Abstract Convolutional Neural Networks (CNNs) are one of the factors supporting the rapid development of artificial intelligent techniques. However, as the ability of the network increases, the size of the network becomes larger. Thus far, several works related to reduction of the network size have been tackled. In many cases, these approaches produce an unstructured network which prevents efficient parallel computation. To avoid this problem, we propose a novel structured sparse fully connected layer (FCL) in the CNNs. The aim of our proposed approach is reduction of the number of network parameters in the FCLs which occupy a large part of network parameters. Unlike the general FCLs used in the popular CNNs such as VGG‐16, the proposed approach reduces the connection between the last convolutional layer and the first FCL. In addition, we show an implementation for the proposed sparse FCLs on the GPU using cuBLAS. As a result for ILSVRC‐2012 dataset, the proposed approach achieves a 21.3 times compression with 0.68% top‐1 accuracy and 0.31% top‐5 accuracy decreases for VGG‐16. The implementation of the proposed FCLs achieves speed‐up factor 14.97 and 16.67 for forward and backward propagation compared to that for the noncompressed FCLs, respectively.
Development of Fault Detection System using Wavelength Division Multiplexing Transmission of Optical Fiber Current Sensor (2010)

A fault detection system is applied to power lines consisting of both overhead power line and underground power cable in order to detect a fault on the underground power cable section and prevent the automatic reclosing.The fault detection system using optical fiber current sensor has two subjects. The fist subject is that we have to use wound-type current transformer together, when applying the fault detection system to single-core underground power cable. The second subject is that we are not able to detect three-phase short-circuit fault in using the fault detection system.This paper describes that we developed a new fault detection system using optical fiber current sensor by applying the multiplex transmission technology of optical fiber current sensor signal in order to solve these subjects.
<title>Dissolution kinetics of chemically amplified resists</title> (1993)

The dissolution rate characteristics of two typical DUV chemically amplified resists (negative resist A and positive resist B) were investigated, by comparing with an i-line novolac resist (resist C). The negative resist A here was based on crosslinking between phenolic resin and melamine derivatives, and the positive resist B was composed of tert-BOC protected phenolic resin.
109 TSPO Ligand FGIN-1-27 Controls Priapism in Sickle Cell Mice via Endogenous Testosterone Production (2021)

Priapism, a prolonged and painful penile erection in the absence of sexual arousal, is common among patients with Sickle cell disease (SCD). Hypogonadism, due to reduced cholesterol transport to Leydig cell mitochondria required for testosterone production, is also common in these patients. Administration of exogenous testosterone to reverse hypogonadism, however, is contraceptive. We hypothesized that stimulation of endogenous testosterone production decreases priapism in SCD by normalizing molecular signaling involved in penile erection without decreasing intratesticular testosterone production, which would affect fertility.
P2‐176: Prevalence of Mild Behavioral Impairment (MBI) in a Memory Clinic Population and the Impact on Caregiver Burden (2016)

Neuropsychiatric symptoms (NPS) have been associated with cognitive decline in persons with MCI or normal cognition. Recently, Mild Behavioural Impairment (MBI) has been proposed as a syndrome by an Alzheimer’s Association consensus group 1, which defines later-life acquired NPS as possible harbingers of neurodegeneration. These NPS are described in the domains of apathy, mood, impulse control, social appropriateness, and psychosis. However, there are few data on the prevalence of NPS and the affected domains in symptomatic patients with MCI or subjective cognitive decline. We report the prevalence and characteristics of NPS in a memory clinic population, grouped by MBI domains. We analyzed neuropsychiatric inventory questionnaires (NPI-Q) from 282 consecutive patients with subjective cognitive decline or MCI, recruited from 1 January 2010 to 30 September 2015. Zarit Caregiver Burden Scale (15 item) was used to determine caregiver burden (n=245, 87%). Descriptive statistics were performed to identify frequency of NPS (present or absent) by domain, with Chi square tests performed when appropriate. Mean age was 60.7 with 13.8 years of education. The prevalence of any NPS was 81.6% (n=230). For MBI domains frequencies of NPS were: 1) mood 77.8%; 2) impulse control 64.4%; 3) apathy 51.7%; 4) social appropriateness 27.8%; and 5) psychosis 8.7%. Any NPS were reported in 76.5% of SCD and 83.5% of MCI participants. There was no gender or age difference in NPS prevalence (p=.63; p=.56). Mean MoCA (23.5) and MMSE (27.8) scores in participants with NPS were not significantly different than participants without NPS (p=.25; p=.18). However, mean caregiver burden scores were significantly greater in MBI (19.1 vs. 5.4; p<.001).
Microprobing the mechanical effects of varying dielectric porosity in advanced interconnect structures (2012)

Chip-package interaction has become a major concern due to increasingly porous low-K dielectrics. During the packaging process, shear stresses are exerted on fragile interconnect structures. We use a microprobe metrology system to experimentally measure how interconnect stacks with different dielectric porosities behave under various shear loading conditions and a wide range of temperatures.
Ada usage/performance specification (1990)

article Free Access Share on Ada usage/performance specification Authors: M. W. Borger View Profile , J. B. Goodenough View Profile Authors Info & Claims ACM SIGAda Ada LettersVolume XIssue 9Fall 1990 pp 65–69https://doi.org/10.1145/102456.102474Published:01 June 1990Publication History 0citation162DownloadsMetricsTotal Citations0Total Downloads162Last 12 Months10Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Reaction of Sulfur and Sustainable Algae Oil for Polymer Synthesis and Enrichment of Saturated Triglycerides (2021)

There is growing interest in the bio-based production of lipids from algae. These lipids have a range of uses including nutritional supplements and precursors to biodiesel. Single-cell thraustochytrids are especially attractive in this regard in that they can produce over 50% of their weight as triglycerides. Furthermore, the distribution of saturated and unsaturated triglycerides can be modulated by changes in strain variation and modulation of fermentation conditions. Nonetheless, there remains a need for versatile downstream processing to enrich these so-called “single cell oils” into classes based on degree of unsaturation. In this study, we report a novel strategy for enriching saturated triglycerides produced in thraustochytrids. The method features direct reaction of elemental sulfur with the algae oil extract. The sulfur copolymerizes with >90% of the unsaturated triglycerides, providing a new route to a class of materials previously used in environmental remediation, Li-S battery cathodes, slow-release fertilisers, and insulation. The unreacted oil is enriched in saturated triglycerides, which can be isolated by extraction for potential use in biodiesel production. In this way, a single batch of sustainably produced algae oil can be converted into multiple useful products in a single step.
A Link-Based Morpho-Syntactic Parsing System for Arabic (2009)

There is an increasing need for having Arabic text parsing tools as an important prerequisite for high-quality natural language processing applications targeting this language. In this paper an attempt to parse Arabic sentences with a link grammar supported with a statistical tokenization phase is presented. This step of the presented work can be considered as a complement to the state-of-the-art tools presented in literature. The problems of such approach are described, followed by a description of untokenized parsing as a solution to the problems of the tokenized approach. The two systems presented, take as input untokenized Arabic sentences and produce the possible linking graphs.