gebhart/patrepeval huggingface dataset:
On-Clamp vs. Off-Clamp Robot-Assisted Partial Nephrectomy for cT2 Renal Tumors: Retrospective Propensity-Score-Matched Multicenter Outcome Analysis (2022)

We compared perioperative outcomes after on-clamp versus off-clamp robot-assisted partial nephrectomy (RAPN) for >7 cm renal masses. A multicenter dataset was queried for patients who had undergone RAPN for a cT2cN0cM0 kidney tumor from July 2007 to February 2022. The Trifecta achievement (negative surgical margins, no severe complications, and ≤ 30% postoperative estimated glomerular filtration rate (eGFR) reduction) was considered a surrogate of surgical quality. Overall, 316 cases were included in the analysis, and 58% achieved the Trifecta. A propensity-score-matched analysis generated two cohorts of 89 patients homogeneous for age, ASA score, preoperative eGFR, and RENAL score (all p > 0.21). Compared to the on-clamp approach, OT was significantly shorter in the off-clamp group (80 vs. 190 min; p < 0.001), the incidence of sRFD was lower (22% vs. 40%; p = 0.01), and the Trifecta rate higher (66% vs. 46%; p = 0.01). In a crude analysis, >20 min of hilar clamping was associated with a significantly higher risk of sRFD (OR: 2.30; 95%CI: 1.13−4.64; p = 0.02) and with reduced probabilities of achieving the Trifecta (OR: 0.46; 95%CI: 0.27−0.79; p = 0.004). Purely off-clamp RAPN seems to be a safe and viable option to treat cT2 renal masses and may outperform the on-clamp approach regarding perioperative surgical outcomes.
The Pavement as a Waveguide: Modeling, System Identification, and Parameter Estimation (2014)

This paper presents modeling of wave propagation in pavements from a system identification point of view. First, a model based on the physical structure is derived. Second, experiment design and evaluation are discussed and maximum-likelihood estimators for estimating the model parameters are introduced, assuming an error-in-variables setting. Finally, the proposed methods are applied to measurement data from two experiments under varying environmental conditions. It is found that the proposed methods can be used to estimate the dispersion curves of the considered waveguide and the results can be used for further analysis.
Supplementary Data 4 from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis (2023)

&lt;p&gt;PDF file - 160K, Data mining of microarray data showing the connections between EMT and autophagy-related genes&lt;/p&gt;
A Bird-Inspired Perching Landing Gear System1 (2019)

Abstract The design, modeling, simulation, and testing of a landing gear system that enables a UAV to perch on an object or surface is presented here. The working principle of the landing gear is inspired by the anatomy of birds that grasp and perch as tendons in their legs and feet are tensioned. In a similar fashion, as the UAV sets down on a structure, its weight tensions a cable which actuates opposing, flexible, multi-segment feet to enclose the target. To analyze the grasping capability of the design, a hybrid empirical–computational model is developed that can be used to simulate the kinematics of the system as it grasps objects of various cross-sectional shapes and sizes. The model relates the curvature of the feet to the displacement and tension of the cable tendon. These quantities are then related to the weight of the UAV through the leg geometry. It also evaluates enclosure and calculates contact forces to quantitatively characterize the grasp. Results demonstrate how the model can be used by designers to determine how a UAV can perch upon a structure of a given shape and size. If perched, the minimum weight required to maintain its position is calculated. A prototype system was fabricated, analyzed, and tested on a radio-controlled hexacopter. Experiments show that the landing gear enables the hexacopter to land, perch, and takeoff from a variety of objects. Finally, we begin to investigate the scalability of the concept with a smaller, lighter design.
Stochastic optimization of an Electric Vehicle Fleet Charging with Uncertain Photovoltaic Production (2015)

Simultaneous development of photovoltaic generation and electric vehicles strengthens the solicitations on the electric power system. This paper investigates the possible synergy between these players to jointly improve the production predictability while ensuring a low carbon mobility. It stands for a step towards a quantification of its economic and environmental fallout. First a context is described for a PV-EV collaboration. Then this is gathered into an optimization problem. Grid commitment constraints, battery aging and mobility needs are here considered from the environmental point of view of equivalent primary energy. Finally, a resolution method is presented which achieve an time-efficient optimization of the power flow for each vehicle, based on upstream computed charging policies. It relies on a stochastic modeling of both vehicles availability and forecast error of the PV production. The resolution framework is the stochastic dynamic programming, coupled with on-line minimization so as to avoid the curse of dimensionality. The proposed resolution enables to compute optimal power flow for each vehicle, even among large fleets. The emphasis is here set on a versatile resolution method which could take over many detailed objective functions.
Phytotoxicity, Toxicity on Brine Shrimp and Insecticidal Effect of Chrysophthalmum gueneri Aytac & Anderb. Growing in Turkey (2018)

Our results show that the n-hexane and chloroform fractions of <i>C. gueneri</i> had potential phytotoxic effects.
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl2 (2022)

Depending on regulatory requirements, the skin sensitization risk for new chemicals with potential consumer skin contact must be assessed by experimental testing by (i) binary hazard assessment to identify sensitizers, (ii) subclassification of sensitizers according to the Global Harmonized System (GHS), and (iii) derivation of a point of departure (PoD) for risk assessment. The Organisation for Economic Co-operation and Development (OECD) recently published a test guideline incorporating the “2 out of 3” defined approach (2o3 DA) for skin sensitization hazard assessment and added the kinetic direct peptide reactivity assay (kDPRA) as a stand-alone test guideline method for GHS subclassification. The 2o3 DA requires that at least two in vitro tests are conducted. The cell-based tests and the kDPRA generate, next to a binary outcome with a fixed threshold, continuous concentration-response data, which can be used in quantitative regression models to derive a PoD. The sequence of testing for the 2o3 DA is flexible. Here we compare different testing sequences and how they can be combined with kDPRA data to provide a PoD in parallel to hazard identification (hazard ID) and GHS subclassification. A set of 188 chemicals with available in vitro data was evaluated for the final PoD using these different testing sequences. The results indicate that testing can start with DPRA / kDPRA and either of the cell-based assays, and that testing can stop after two congruent tests without major impact on the final PoD for chemicals within the applicability domain of the kDPRA.
The reaction mechanism of rat liver glyoxalase I and its inhibition by MS-3. (1976)

Glyoxalase I from rat liver was purified about 25-fold by acetone fractionation and ionexchange chromatography on CM-Sephadex and DEAE-cellulose columns. The kinetic study of the enzymatic reaction supported the one-substrate mechanism: the hemimercaptal adduct produced nonenzymatically from methylglyoxal and glutathione is the substrate. The Km value determined was 0.1mM and similar to that of porcine erythrocytes enzyme but differed significantly from that of yeast enzyme. It was inhibited by free glutathione competitively (Ki 1.2mM). Kinetic studies on inhibition of glyoxalase I by MS-3 which was obtained from a cultured mushroom, Stereum hirsutum, indicated the inhibition type was competitive with the hemimercaptal adduct (Ki 4.6×10-6M). By the graphical study of the multiple inhibition kinetics free glutathione and MS-3 were shown to bind at the same sites of the enzyme.
State-feedback control of grid and circulating current in modular multilevel converters (2020)

This paper proposes a state-feedback control of both grid and circulating current in modular multilevel converters (MMCs), which ensures that the input-coupled dynamics of the two currents to be controlled within a multi-input–multi-output (MIMO) approach. A systematic design procedure is detailed and the strategy is validated on a comprehensive MATLAB®/Simulink® model of a three-phase MMC. Simulation results show that, compared with the conventional control featuring two separate control loops, the proposed control shows better performance under unbalanced grid conditions.
Egomotion estimation using planar and non-planar constraints (2010)

There are two major approaches for estimating camera motion (egomotion) given an image sequence. Each approach has own strengths and weaknesses. One approach is the feature based methods. In this approach the point feature correspondences are taken as the input. Since initially the depths of point features are unknown, the egomotion is estimated by the depth independent epipolar constraints on the point feature correspondences. This approach is robust in practice, but is relatively limited in accuracy since it exploits no structure assumption, such as planarity. The other approach, termed the direct method, has the advantage in its accuracy. In this method, the egomotion is estimated as the parameters of a homography by directly aligning the planar potion of two images. The direct method may be preferable in the cases with known planes that are persistent in the view. The on-board camera system for ground vehicles is a representative example. Despite the potential accuracy, the direct method fails when the plane lacks proper texture. We propose an egomotion estimation method that is based on both the homographic constraint on a planar region, and on the epipolar constraint on generally non-planar regions, so that the both kinds of visual cues contribute to the estimation. We observe that the method improves the egomotion estimation in robustness while retaining the comparable accuracy to the direct method.
Discrete-frequency infrared microspectroscopy using monolithically integrated photonic filters (2015)

We present a discrete-frequency infrared (DF-IR) approach to efficient mid-infrared microspectroscopy using a set of monolithically integrated guided mode resonance photonic filters, as an alternative to the continuously scanning Fourier transform infrared (FT-IR) technique.
Technologiebericht 3.1 Stromtransport und -verteilung innerhalb des Forschungsprojekts TF_Energiewende (2018)

A) Technologien zur Erhhung der Netzkapazitt:1. Technologien zur besseren Auslastung bzw.berlastbarkeit bestehender Betriebsmittel: u. a. Einbezug von Wetterprognosen und Zustandsinformationen, Verbesserung der Systemeigenschaften (z.B. erweiterte dynamische berlastungsfhigkeit). 2. Neue Betriebsmittel, und.Verbesserung der Systemeigenschaften (z.B. Regelungsverfahren,
Search for massive, long-lived particles using multitrack displaced vertices or displaced lepton pairs inppcollisions ats=8  TeVwith the ATLAS detector (2015)

Search for massive, long-lived particles using multitrack displaced vertices or displaced lepton pairs in pp collisions at ffiffi s p 8 TeV with the ATLAS detector
On Reducing Multiband Spectrum Sensing Duration for Cognitive Radio Networks (2016)

In this work, the total spectrum sensing duration required for cognitive radios in multiband environments is studied to minimize the reactive handoff latency. Two spectrum sensing strategies, namely window-based and sample-based sensing, are evaluated to estimate channel workload and idle time probability. Channel workload is the percentage of time the band is used by other wireless networks. Idle time probability is defined as the probability of usable durations for the cognitive radio communications. The mean square error performance of the estimations is provided for both sensing strategies in the case of energy detection based sensing and realistic interarrival time distribution of packets. It is shown that, sample-based strategy requires half of the total multiband spectrum sensing duration compared to its window-based counterpart, if the hardware switching delay is under a specific threshold.
Effect of the L499M mutation of the ascomycetousBotrytis acladalaccase on redox potential and catalytic properties (2014)

Laccases are members of a large family of multicopper oxidases that catalyze the oxidation of a wide range of organic and inorganic substrates accompanied by the reduction of dioxygen to water. These enzymes contain four Cu atoms per molecule organized into three sites: T1, T2 and T3. In all laccases, the T1 copper ion is coordinated by two histidines and one cysteine in the equatorial plane and is covered by the side chains of hydrophobic residues in the axial positions. The redox potential of the T1 copper ion influences the enzymatic reaction and is determined by the nature of the axial ligands and the structure of the second coordination sphere. In this work, the laccase from the ascomycete Botrytis aclada was studied, which contains conserved Ile491 and nonconserved Leu499 residues in the axial positions. The three-dimensional structures of the wild-type enzyme and the L499M mutant were determined by X-ray crystallography at 1.7 Å resolution. Crystals suitable for X-ray analysis could only be grown after deglycosylation. Both structures did not contain the T2 copper ion. The catalytic properties of the enzyme were characterized and the redox potentials of both enzyme forms were determined: E0 = 720 and 580 mV for the wild-type enzyme and the mutant, respectively. Since the structures of the wild-type and mutant forms are very similar, the change in the redox potential can be related to the L499M mutation in the T1 site of the enzyme.
[A Case of Laparoscopically Resected Sigmoid Colon Cancer and Transverse Colon Mesentery Primary Solitary Fibrous Tumor]. (2022)

The patient is a 52-year-old woman who visited the general practitioner because of positive fecal occult blood test by medical examination. The patient underwent colonoscopy at the hospital, which revealed sigmoid colon cancer. Therefore, the patient was referred to our hospital for surgery. Preoperative CT scan revealed a well-defined and lobulated 54 mm tumor on the caudal side of the duodenal third portion. On MRI, the tumor showed low T1-weighted image signal and high T2-weighted and diffusion-weighted images signal, with low ADC. For preoperative diagnosis, we diagnosed sigmoid colon cancer and transverse colon mesenteric and performed laparoscopic sigmoid colon and transverse colon mesenteric tumor resections. The histopathological tumor diagnoses were sigmoid colon cancer(S, type 2, 30×30 mm, 1/2 circumference, moderately differentiated adenocarcinoma, pT3[SS], INF b, Ly1a, V1a, pN1b[#252: 2/4], sM0, fStage Ⅲb)and transverse colon mesentery primary solitary fibrous tumor. The patient was treated with XELOX as the adjuvant chemotherapy and survived without recurrence until present.
Technical Assessment of Novel Hydrogen Producing Solid Oxide Fuel Cell Power System (2021)

Solid oxide cell-based electrolysis (SOEC) systems are being considered for hydrogen production due to their potential for high efficiencies and for their integrability with base load power generation systems when operated in solid oxide fuel cell (SOFC) mode. However, a cost prohibitive combination of SOFC power systems and SOEC systems may be required to operate the plant flexibly to produce a combination of H2 and power on-demand. A single (consequently less expensive) reversible SOFC/SOEC system, on the other hand, poses technological challenges related to the on demand switching between power and H2 production. This report provides a high-level technical assessment of a novel SOFC based H2 production concept that averts the potential drawbacks of the SOEC systems. The novel concept combines the advantages of steam-reforming of natural gas to produce H2 with the high efficiency power generation capabilities of a SOFC in a single package.
Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment (2018)

Type 2 diabetes (T2D) is a complex and progressive disease requiring polypharmacy to manage hyperglycaemia and cardiovascular risk factors. However, most patients do not achieve combined treatment goals. To address this therapeutic gap, we have developed MEDI4166, a novel glucagon-like peptide-1 (GLP-1) receptor agonist peptide fused to a proprotein convertase subtilisin/kexin type 9 (PCSK9) neutralising antibody that allows for glycaemic control and low-density lipoprotein cholesterol (LDL-C) lowering in a single molecule. The fusion has been engineered to deliver sustained peptide activity in vivo in combination with reduced potency, to manage GLP-1 driven adverse effects at high dose, and a favourable manufacturability profile. MEDI4166 showed robust and sustained LDL-C lowering in cynomolgus monkeys and exhibited the anticipated GLP-1 effects in T2D mouse models. We believe MEDI4166 is a novel molecule combining long acting agonist peptide and neutralising antibody activities to deliver a unique pharmacology profile for the management of T2D.
A novel coumarin, (+)-3′-angeloxyloxy-4′-keto-3′,4′-dihydroseselin, isolated from Bupleurum malconense (Chaihu) inhibited NF-κB activity (2016)

Pd-Ib isolated from B. malconense suppressed LPS-induced inflammatory responses in macrophages by inhibiting NF-κB activity and reducing the expression of iNOS, COX-2 as well as pro-inflammatory cytokines.
Sulfated Metabolites fromMycobacterium tuberculosis: Sulfolipid-1 and Beyond (2014)

Sulfated metabolites are abundant in higher eukaryotes, where they play roles in cell-to-cell communication. This chapter highlights recent advances in the understanding of sulfolipid-1 (SL-1) biosynthesis and discusses the potential biological significance of SL-1 and other sulfated metabolites in the context of both historical observations and modern experiments. Sequencing of the Mycobacterium tuberculosis genome in 1998 provided the tools necessary to draw links from gene to protein and metabolite. A signaturetag mutagenesis (STM) screen identified mmpL7 as a gene essential for M. tuberculosis growth in a mouse model of infection. Sulfate ester functionality distinguishes SL-1 from other well-characterized mycobacterial lipids. Recently, Gap, a small integral membrane protein from Mycobacterium smegmatis was shown to be required for transport of glycopeptidolipids to the cell surface. In vivo analysis of the Δpks2 mutants left the SL-1 community questioning the importance of the molecule that had previously garnered so much attention. Attenuation of the ΔmmpL8 mutant in the persistent stage of M. tuberculosis infection contrasts with the reported phenotype of the Δpks2 mutants. Although M. tuberculosis is the most extensively studied species of the mycobacterial genus, several other mycobacteria have medical importance owing to their synergism with human immunodeficiency virus. One such species is the opportunistic environmental mycobacterium Mycobacterium avium, which preferentially infects individuals with compromised immunity. This pathogen also encodes nine putative sulfotransferases, the largest number of sulfotransferases of any sequenced mycobacterial species. As one's knowledge of human immunity grows, better cellular and in vivo models for M. tuberculosis virulence will be created.
RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence. (1989)

A region in the adenovirus major late promoter (MLP) containing a CCAAT consensus sequence can direct transcription termination of RNA polymerase II, a mechanism that possibly prevents transcriptional interference from upstream genes. Using a chimeric plasmid template that contains the MLP directing expression of the simian virus 40 early region, we showed that an inserted oligonucleotide containing only 13 base pairs of MLP sequences, including the CCAAT box, is capable of inducing transcription termination in an orientation-dependent, position-independent manner. Point mutations within the CCAAT-specific protein-binding site abolished this effect, while a base substitution outside of this region did not affect termination. These data suggest that termination is mediated by a CCAAT box-binding protein. Several other transcription factor-binding sites do not, however, cause termination, suggesting that this may be a relatively specific property of a CCAAT-binding protein.
Extending Electrochemical Quartz Crystal Microbalance Techniques to Macroscale Electrodes: Insights on Pseudocapacitance Mechanisms in MnOx-Coated Carbon Nanofoams (2015)

Electrochemical quartz crystal microbalance studies of MnOx-coated carbon nanofoams reveal that charge-compensation mechanisms associated with MnOx pseudocapacitance in mild aqueous electrolytes are dominated by anion insertion rather than more commonly reported cation ejection. Specific charge-compensation behavior depends on such factors as electrolyte composition, nanofoam pore size, and polarization amplitude. For example, MnOx–carbon nanofoams with average pore sizes of 5–20 nm, cycled in 2.5 M LiNO3, reveal a kinetically-hindered, mixed anion-cation charge-compensation mechanism, whereas the same nanofoam cycled in 2.5 M NaNO3 shows only anion association. Nanofoams with larger pores (10–200 nm) that are cycled in 2.5 M LiNO3, reveal anion-only charge compensation. Our results demonstrate that critical new insights on charge-storage mechanisms are achieved using EQCM methods, even when analyzing practical, macroscale electrodes such as carbon nanofoams.
Ultrafast carrier dynamics in size-controlled, self-assembled, InGaAs/GaAs quantum dots (2001)

Summary form only given. We describe measurements of carrier energy relaxation in a set of InGaAs/GaAs with various sizes resulting in energy level spacing (/spl Delta/E) ranging from /spl sim/65 meV to /spl sim/95 meV. We demonstrate that in all cases the relaxation is extremely rapid but slows with increasing /spl Delta/E. This behavior is highly suggestive of relaxation through phonon emission. Optical phonon energies of 29.6, 32.6, and 37.6 meV have been reported previously in InAs/GaAs self-assembled QDs. Thus, depending on the relative distribution of energy among the electron and hole levels, relaxation through single phonon emission (for both electrons and holes) is possible for /spl Delta/E /spl sim/65 meV, but multiphonon emission is required for /spl Delta/E /spl sim/95 meV. Phonon participation in the relaxation is also suggested by the temperature dependence of the measured relaxation rates and by measurements of the excited-state dynamics.
On performance evaluation methods and control strategies for semi-active suspension systems (2004)

The problem considered in this paper is the design and analysis of a control system for semi-active suspensions in road vehicles. Three control strategies are tested: the two-state skyhook damping, the linear skyhook damping, and a newly-proposed control strategy based on two-state switching dampers. In order to assess and to compare the closed-loop performance of these control strategies, an evaluation method based on the describing-function is proposed. This evaluation approach provides, in the frequency-domain, a clear picture of the closed-loop performance on the body acceleration (comfort objective) and on the vertical load at the road-tire contact surface (handling objective). This evaluation method inherently provides a quantitative estimate of the degree of input/output non-linearity of the closed-loop system.
Organic user interfaces (2008)

Displays on real-world objects allow more realistic user interfaces.