gebhart/patrepeval huggingface dataset:
Dynamic resource allocation in heterogeneous networks (2013)

LTE systems do not suffer from intra-cell interference, but they are affected by interference coming from adjacent cells. However, most of the research on resource allocation and repetition protocols has not paid attention to the interference case. In this paper, we consider the problem of dynamic resource allocation for IR-HARQ schemes under the presence of interference. We consider resource allocation by means of rate and physical dimensions adaptation in each HARQ round. We provide a mathematical framework that can be applied for the analysis of heterogeneous networks. Rather than performing extensive simulations, we take an information theoretic approach to derive analytical expressions that represent the long-term throughput of the network and we consider distributed resource allocation policies. Our policies are applicable for both the uplink and downlink channels.
Volterra-based Nonlinear Compensation in 400 Gb/s Multiband coherent OFDM Systems (2014)

International audience
Fundamentals in traffic engineering. 12th edition (1988)

These notes are designed mainly for one week short courses on the fundamentals of traffic engineering, with a california audience in mind. In recent years, however, they have seen increasing use in university engineering courses and individual study throughout north America and beyond. The notes do not include all the material required for any of these purposes; the student or reader will need access to such standard references as transportation and traffic engineering handbook (institute of transportation engineers), manual on uniform traffic control devices (United States federal highway administration), highway capacity manual, 1985 (transportation research board), manual of traffic engineering studies (institute of transportation engineers), and policy on geometric design of highways and streets (American association of state highway and transportation officials) for more detailed information. This 12th edition includes new and updated material that may also be useful to the practicing traffic engineer. In particular, it reflects the publication of new editions of the highway capacity manual and the policy on the geometric design on highways and streets, both of which occurred since the 11th edition of these notes went to press. Several other chapters have been greatly revised. A new appendix, summarizing statistical methods commonly used in traffic engineering work, has been added. On the other hand, the appendix which translated certain data in past editions from British to metric units has been reduced to a single table of equivalents in view of the lack of progress in the united states in converting to the si system of units.
Recent Progress in Non-Contact Electrical Characterization for SiC and Related Compounds (2023)

An increasing interest in the non-contact corona charge-based electrical characterization technique, CnCV, for wide bandgap semiconductors, is justified by the reduction of cost and the reduction of testing feedback time [1]. In addition, the technique expands measurement capabilities. Regarding SiC, recent progress includes expanded dopant concentration range and dopant measurement on fresh epitaxial wafers. The latter is made possible with an ultraviolet wafer pretreatment technique [2]. The novel applications to AlGaN/GaN HEMT on insulating substrates demonstrate the benefits of a noninvasive top side edge contact, TSEC [3], that eliminates the problem of the floating surface potential. This development enables a unique three variable, charge-voltage-capacitance (Q-V-C), characterization of AlGaN/GaN on sapphire and SI-SiC. The quasistatic CnCV measurement, not affected by series resistance, is shown to be suitable for wafer mapping of HEMT parameters. The CnCV version with TSEC can be combined with an eddy current technique enabling non-contact 2DEG mobility measurements vs. electron sheet density.
The 3PAs: An Update on the Association of Pheochromocytomas, Paragangliomas, and Pituitary Tumors (2018)

Pituitary adenomas (PA) and pheochromocytomas/paragangliomas (PHEO/PGL) are rare tumors. Although they may co-exist by coincidence, there is mounting evidence that genes predisposing in PHEO/PGL development, may play a role in pituitary tumorigenesis. In 2012, we described a GH-secreting PA caused by an <i>SDHD</i> mutation in a patient with familial PGLs and found loss of heterozygosity at the <i>SDHD</i> locus in the pituitary tumor, along with increased hypoxia-inducible factor 1α (HIF-1α) levels. Additional patients with PAs and SDHx defects have since been reported. Overall, prevalence of SDHx mutations in PA is very rare (0.3-1.8% in unselected cases) but we and others have identified several cases of PAs with PHEOs/PGLs, like our original report, a condition which we termed the 3 P association (3PAs). Interestingly, when 3PAs is found in the sporadic setting, no <i>SDHx</i> defects were identified, whereas in familial PGLs, <i>SDHx</i> mutations were identified in 62.5-75% of the reported cases. Hence, pituitary surveillance is recommended among patients with <i>SDHx</i> defects. It is possible that the <i>SDHx</i> germline mutation-negative 3PAs cases may be due to another gene, epigenetic changes, mutations in modifier genes, mosaicism, somatic mutations, pituitary hyperplasia due to ectopic hypothalamic hormone secretion or a coincidence. PA in 3PAs are mainly macroadenomas, more aggressive, more resistant to somatostatin analogues, and often require surgery. Using the <i>Sdhb</i> <sup>+/-</sup> mouse model, we showed that hyperplasia may be the first abnormality in tumorigenesis as initial response to pseudohypoxia. We also propose surveillance and follow-up approach of patients presenting with this association.
Subnanosecond Ultra-Low Power Consumption 3-Dimensional NB RAM. Phase 1. (1997)

Abstract : A comprehensive study of possible high-performance superconductive RAM architectures has been conducted. The result of this study is a novel block access RAM architecture with an access time approx. 300 Ps. Several types of RAM cell have been evaluated by simulation. Two different types of these RAM cells have been experimentally evaluated.
Lymphocyte Homing to the Liver (2004)

The liver has a large population of resident lymphocytes that survey the liver under normal conditions but can be rapidly expanded through recruitment and proliferation in response to various insults. The tissue-specific homing molecules for tissues such as intestine and skin are well characterized, but liver-specific homing molecules are still not known. The molecules that have been implicated in liver homing are also selectins, integrins, and chemokines, as in other tissues, however, the unique flow conditions, architecture, and specialized cell populations allow different molecules to play prominent roles in various microenvironments within the liver. In this review, we take a closer look at adhesion molecules (selectins, α4β7, α4β1, αLβ2, and vascular adhesion protein-1) and “inflammatory” chemokine receptors (CXCR3, CCR5, and CXCR6) under various inflammatory conditions and compartments within the liver. Their prominent roles in accumulating lymphocytes to inf lamed liver suggest its importance as possible therapeutic targets for human liver diseases. Keywords: chemokines, homing, integrins, liver, lymphocytes
Induction of Specific Transcription by RNA Polymerase III in Transformed Cells (1986)

RNA polymerase III (pol III) transcripts of the highly repeated mouse B2 gene family are increased in many oncogenically transformed murine cell lines. In cells transformed by simian virus 40, the small, cytoplasmic B2 RNAs are present at 20-fold-higher levels than in normal cells (M. R. D. Scott, K. Westphal, and P. W. J. Rigby, Cell 34:557-567, 1983; K. Singh, M. Carey, S. Saragosti, and M. Botchan, Nature [London] 314:553-556). We found that transcripts of the highly repeated B1 gene family are also increased 20-fold upon simian virus 40 transformation and showed that these RNAs result from pol III transcription. In contrast, transcripts from less highly repeated pol III templates such as the 5S, 7SL, 7SK, 4.5SI, tRNAMet, and tRNAPro genes are unaffected. The expression of the B2 RNAs in isolated nuclei shows that the augmentation is due mainly to an increased rate of transcription by pol III. There is thus specific transformation-inducible pol III transcription. We developed an in vitro transcription assay which utilizes genomic DNA as a template to study the transcription of all members of a repetitive gene family in their native context. This assay reproduces the low cytoplasmic levels of B1 compared with B2 RNAs suggesting that this ratio is dictated by intrinsic signals in the DNA.
Environmental Impact Assessment of an Anaerobic Codigestion System in Western New York State (2013)

Anaerobic codigestion of dairy manure and food-based feedstocks reflects a cradle-to-cradle approach to organic waste management. Given both of their abundance throughout New York State, waste-to-energy processes represent promising waste management strategies. The existing waste-to-energy literature has not yet fully realized the environmental impacts associated with displaced grid electricity generation and feedstock-hauling emissions on the net environmental impact of centralized codigestion facilities. The key objective of this study is to provide a comprehensive environmental impact assessment with the purpose of understanding the existing environmental status of centralized codigestion facilities. Real-time data from an operational codigestion facility located in Western New York State was used to conduct this environmental impact statement. A comprehensive inventory of greenhouse gas emissions associated with renewable electricity production at the codigestion facility was developed using the Emissions &amp; Generation Resource Integrated Database (eGRID) (U.S. EPA), while emissions associated with feedstock hauling were quantified using the fuel life-cycle approach developed by the Greenhouse gases, Regulated Emissions, and Energy use in Transportation model (GREET) (U.S. DOE). With each of the emissions models used for this analysis, it was determined that the net environmental impact associated with hauling food-related feedstocks from the many locations throughout the Northeast U.S. region would be acceptably low, and thus could be part of future sustainable development of centralized codigestion facilities.
Table S2 from Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death (2023)

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Development of a Micro RNA Extraction Chip from Human Tumor Cells (2015)

The importance of micro RNA analysis has been significantly increasing because the role of micro RNA in the human body has been gradually revealed. Despite its importance, the analysis has suffered from several troublesome pretreatments, which hamper any easy analysis. Therefore, an easy and high-throughput pretreatment method has been demanded. In this paper, we focused on the great advantages of microchip pretreatments over conventional manual pretreatments and developed a microchip for micro RNA extraction. To simplify microchip fabrication, we adopted poly(dimethyl siloxane) (PDMS) microchip and a silica membrane, which has rolls in RNA extraction fields. With silica membranes and the adhesion nature of PDMS, we could easily fabricate RNA extraction fields in the microchip. With this microchip, we successfully extracted micro RNA from cancer tumor cells. Though this is a preliminary experiment, and still has many improvement points, our device is expected to be applied for easy and fast micro RNA extraction from biological samples.
A comparison study of atlas-based image segmentation: the advantage of multi-atlas based on shape clustering (2009)

Purpose: By incorporating high-level shape priors, atlas-based segmentation has achieved tremendous success in the area of medical image analysis. However, the effect of various kinds of atlases, e.g., average shape model, example-based multi-atlas, has not been fully explored. In this study, we aim to generate different atlases and compare their performance in segmentation. Methods: We compare segmentation performance using parametric deformable model with four different atlases, including 1) a single atlas, i.e., average shape model (SAS); 2) example-based multi-atlas (EMA); 3) cluster-based average shape models (CAS); 4) cluster-based statistical shape models (average shape + principal shape variation modes)(CSS). CAS and CSS are novel atlases constructed by shape clustering. For comparison purpose, we also use PDM without atlas (NOA) as a benchmark method. Experiments: The experiment is carried on liver segmentation from whole-body CT images. Atlases are constructed by 39 manually delineated liver surfaces. 11 CT scans with ground truth are used as testing data set. Segmentation accuracy using different atlases are compared. Conclusion: Compared with segmentation without atlas, all of the four atlas-based image segmentation methods achieve better results. Multi-atlas based segmentation behaves better than single-atlas based segmentation. CAS exhibit superior performance to all other methods.
Personalization of Hearing Aid Compression by Human-in-the-Loop Deep Reinforcement Learning (2020)

Existing prescriptive compression strategies used in hearing aid fitting are designed based on gain averages from a group of users which may not be necessarily optimal for a specific user. Nearly half of hearing aid users prefer settings that differ from the commonly prescribed settings. This paper presents a human-in-the-loop deep reinforcement learning approach that personalizes hearing aid compression to achieve improved hearing perception. The developed approach is designed to learn a specific user's hearing preferences in order to optimize compression based on the user's feedbacks. Both simulation and subject testing results are reported. These results demonstrate the proof-of-concept of achieving personalized compression via human-in-the-loop deep reinforcement learning.
FIR modeling using log-bispectra: weighted least-squares algorithms and performance analysis (2002)

Identification of non-minimum-phase systems with finite impulse response (FIR) is addressed in the bispectrum domain. A phase retrieval algorithm, based on the log-bispectrum, is extended to log-magnitude reconstruction. Both linear-equation-based estimators are then combined to form an integrated, nonparametric system identification method. Weighted forms of these estimators are developed, which are asymptotically minimum-variance in the class of weighted least-squares estimators. Asymptotic variance expressions are derived for both the weighted and the unweighted forms. Theory and simulations illustrate that the approaches can identify non-minimum-phase MA (moving-average) models using output data which may be corrupted by additive Gaussian noise of unknown covariance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Influence of Food Intake on the Pharmacokinetics of Miglustat, an Inhibitor of Glucosylceramide Synthase (2007)

The objective of this study was to investigate the effect of food on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. Twenty-four healthy male (n = 9) and female (n = 15) subjects were treated in a randomized, 2-way crossover design with a single oral dose of 100 mg miglustat with or without food. Consumption of a standard high-fat breakfast within 30 minutes before administration of miglustat significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to miglustat. The peak plasma concentration (C(max)) decreased by 36% on average following administration with food. Area under the plasma concentration-time curve (AUC(0-infinity)) showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. The median (min-max) time to C(max) (t(max)) was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food. In conclusion, the intake of food has an effect on some pharmacokinetic parameters such as C(max) and t(max) but does not affect the extent of exposure to miglustat. The observed effects of food intake on the pharmacokinetics of miglustat are not considered to be of clinical relevance.
Further biodosimetry investigations using murine partial-body irradiation model (2014)

This study evaluates both the effects of physical restraint and use of candidate biomarkers in a CD2F1 male mouse partial-body irradiation model for biological dosimetry diagnostic assays. Mice were irradiated (6-Gy, 250-kVp X ray) to 3/3rd (total body), 2/3rd (gut and torso), 1/3rd (gut only) and 0/3rd (sham) of total body. Blood was sampled for haematology and blood plasma proteomic biomarkers at 1 and 2 d after exposure. Increases in the body fraction exposed showed progressive decreases in lymphocyte counts and increases in the neutrophil-to-lymphocyte ratios with no significant differences in the neutrophil and platelet counts. The radioresponse for plasma biomarker Flt3L showed proportional increases; however, G-CSF and SAA levels exhibited dramatic and non-proportional increases in levels. Physical restraint at 1 d post-exposure increased lymphocyte counts and SAA, decreased neutrophil-to-lymphocyte ratio and Flt3L and showed no effects on neutrophil and platelet counts or G-CSF.
Neuronal Nitric Oxide Signaling Regulates Erection Recovery After Cavernous Nerve Injury (2011)

Neuronal nitric oxide signaling regulates erectile function recovery early after partial cavernous nerve injury, exerting an inhibitory role via the induction of apoptotic change in penile tissue. Therapeutic strategies to improve erectile function recovery after radical prostatectomy may consider targeting pathogenic sites of nitric oxide neurobiology.
Pacemaker Wenckebach Phenomenon Due to Antiarrhythmic Drug Toxicity (1976)

Two patients with intractable ventricular arrhythmia were managed with ventricular pacing and antiarrhythmic drugs. Toxic levels of these drugs results in unusual conduction disturbances at the level of Purkinje ventricular junction which caused pacemaker Wenckebach phenomenon and marked QRS prolongation. Sodium bicarbonate and sodium lactate infusion improved the conduction velocity probably by hyperpolarizing the membrane and reversed the conduction disturbance.
Stereo Vision: The Haves and Have-Nots (2015)

Animals with front facing eyes benefit from a substantial overlap in the visual fields of each eye, and devote specialized brain processes to using the horizontal spatial disparities produced as a result of viewing the same object with two laterally placed eyes, to derived depth or 3-D stereo information. This provides the advantage to break the camouflage of objects in front of similarly textured background and improves hand eye coordination for grasping objects close at hand. It is widely thought that about 5% of the population have a lazy eye and lack stereo vision, so it is often supposed that most of the population (95%) have good stereo abilities. We show that this is not the case; 68% have good to excellent stereo (the haves) and 32% have moderate to poor stereo (the have-nots). Why so many people lack good 3-D stereo vision is unclear but it is likely to be neural and reversible.
Interference cancellation using an array feed design for radio telescopes (2004)

Radio frequency interference (RFI) is a growing problem for radio astronomers. We investigate the use of a phased array feed in order to allow for RFI mitigation with a single reflector. Our primary goal in the design of an array feed is to optimize the array for RFI cancellation while also achieving high sensitivity and beam steering capability. The phased array feed should also produce a higher sensitivity as compared to a single standard waveguide feed. Other design goals include gain stability and low beam shape distortion for steered beams.
Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis (2020)

DNA-encoded library (DEL) technology enables rapid, economical synthesis, and exploration of novel chemical space. Reaction development for DEL synthesis has recently accelerated in pace with a specific emphasis on ensuring that the reaction does not compromise the integrity of the encoding DNA. However, the factors that contribute to a reaction's "DNA compatibility" remain relatively unknown. We investigated several solid-phase reactions and encoding conditions and determined their impact on DNA compatibility. Conditions that minimized the accessibility of reactive groups on the DNA encoding tag (switching solvent, low temperature, double-stranded encoding tag) significantly improved compatibility. We showcased this approach in the multistep synthesis of an acyldepsipeptide (ADEP1) fragment, which preserved 73% of DNA for a >100-fold improvement over canonical conditions. These results are particularly encouraging in the context of multistep reaction sequences to access natural product-like scaffolds and more broadly underscore the importance of reconciling the biophysical properties and reactivity of DNA with chemistry development to yield high-quality libraries of those scaffolds.