gebhart/patrepeval huggingface dataset:
Long-Term Chloride Penetration Resistance of Bridge Decks Made with Silica Fume Concretes (2009)

The effects of pH, Cl-, and humic acid (HA) on sonolytic desorption of Hg(II) from aluminum oxide were examined. Results showed that Hg(II) desorption was achieved by lowering the pH from 7.0 to 4.0. Ultrasound enhanced Hg(II) release at short times compared to both hydrodynamic mixing and that expected on the basis of the pH-dependent Hg(II) adsorption curve. However, prolonged sonication led to decreases in Hg(II) desorption due to occlusion by aluminum hydroxide precipitation induced by ultrasound. The presence of Cl- greatly improved Hg(II) desorption at pH 4.0 due to the formation of stable nonadsorbing HgCl2(0) complexes at low pH, reducing free Hg(II) ion in solution. However, Cl- did not affect Hg(ll) desorption at pH 8.0, where Hg(OH)2(0) is the dominant Hg species rather than HgCl2(0). Hg(ll) desorption from HA-laden Al2O3 was dominated by HA. The greater the desorption of HA, the greater the desorption of Hg(II). Ultrasound enhanced the initial Hg(II) release by facilitating HA desorption. However, decreases in Hg(II) desorption were observed over longer sonication times due to the sonochemically induced reassociation of desorbed HA back onto Al2O3. Information obtained in this study provides insight into understanding sonolytic release of Hg from Hg-contaminated particles and sediments.
Concatenated coding for binary partial-response channels (2002)

Concatenation of outer conventional rate-k/sub c//n/sub c/ binary convolutional coding with inner rate-k/sub t//n/sub t/ special trellis coding for the binary 1-D dicode partial-response channel is investigated. In the scheme considered, code sequences generated by the outer convolutional encoder are time-interleaved prior to trellis encoding. Decoding for the outer convolutional code takes into account the reliability of individual code symbols provided by the inner trellis-decoding stage. The construction of the inner trellis code is based on the partitioning of a set of sequences of noiseless channel-output signals into subsets which are assigned to the branches of a combined encoder and channel trellis. A class of trellis codes is obtained that guarantee a limited number of consecutive zeros at the channel output and allow for a computationally efficient estimation of the reliability of the decoded symbols. It is shown that substantial coding gains can be achieved by this method as compared to the maximum-likelihood sequence detection of uncoded dicode signals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A General Method for Measurement of Enantiomeric Excess by Using Electrooptics in Ferroelectric Liquid Crystals (2007)

It's ee rie: A new method for quantitative measurement of ee values is described. The method exploits the unique electrooptic properties of the chiral smectic A liquid-crystal phase and is potentially applicable to the high-throughput (>106 determinations per day) measurement of ee values for any chiral analyte.
FIVE-COORDINATE COBALT(II) COMPLEXES OF MACROCYCLIC LIGANDS — A NEW REVERSIBLE OXYGEN CARRYING SYSTEM (1977)

Abstract We report the synthesis and characterization of cobalt(II) complexes with two macrocyclic Schiff base ligands, 5,7,7,12,14,14-hexamethyl-1,4,8,11,-tetraazacyclotetradeca-4,11-diene(Me6 [14]4,11-dieneN4) and 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,14-diene(Me6 [14]4,14-dieneN4), containing a large variety of axial ligands. The complexes are low spin and predominantly five-coordinate, the d–d electronic spectra and electron paramagnetic resonance (epr) spectra being consistent with a square pyramidal ligand environment. The complex [Co(Me6 [14] 4,11-dieneN4)] (ClO4)2 functions as a reversible oxygen carrier in several solvents and in the presence of several Lewis bases. Formation of the oxygen adduct in N, N-dimethylformamide (DMF) has been studied spectrophotometrically and by means of epr.
Antimicrobial silica particles synthesized via ring-opening grafting of cationic amphiphilic cyclic carbonates: effects of hydrophobicity and structure (2016)

In this study, cationic amphiphilic cyclic carbonates with varying hydrophobicity and structure were synthesized and grafted onto silica particles to impart antimicrobial properties.
Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis (2016)

Obstructive sleep apnea (OSA) is a common multisystem chronic disorder. Functional and structural neuroimaging has been widely applied in patients with OSA, but these studies have often yielded diverse results. The present quantitative meta-analysis aims to identify consistent patterns of abnormal activation and grey matter loss in OSA across studies. We used PubMed to retrieve task/resting-state functional magnetic resonance imaging and voxel-based morphometry studies. Stereotactic data were extracted from fifteen studies, and subsequently tested for convergence using activation likelihood estimation. We found convergent evidence for structural atrophy and functional disturbances in the right basolateral amygdala/hippocampus and the right central insula. Functional characterization of these regions using the BrainMap database suggested associated dysfunction of emotional, sensory, and limbic processes. Assessment of task-based co-activation patterns furthermore indicated that the two regions obtained from the meta-analysis are part of a joint network comprising the anterior insula, posterior-medial frontal cortex and thalamus. Taken together, our findings highlight the role of right amygdala, hippocampus and insula in the abnormal emotional and sensory processing in OSA.
Supplementary Figure 2 from C-Propeptides of Procollagens Iα1 and II that Differentially Accumulate in Enchondromas versus Chondrosarcomas Regulate Tumor Cell Survival and Migration (2023)

Supplementary Figure 2 from C-Propeptides of Procollagens Iα1 and II that Differentially Accumulate in Enchondromas versus Chondrosarcomas Regulate Tumor Cell Survival and Migration
The modeling and measurement of HF antenna skywave radiation patterns in irregular terrain (1994)

The method of moments (MoM) was used in conjunction with the geometric theory of diffraction (GTD) for predicting the elevation-plane radiation patterns of simple high-frequency (HF) vertical monopoles and horizontal dipoles situated in irregular terrain. The three-dimensional terrain was approximated by seven connected flat plates that were very wide relative to the largest wavelength of interest. The plate length along the terrain profile was the longest possible that still adequately followed the shape of the path on the azimuth of the elevation pattern of interest and no shorter than 1 wavelength at the lowest frequency of interest. The MoM model was used to determine the antenna currents under the assumption that the terrain was planar (i.e., locally flat) over the distance pertinent to establishing the input impedance. The currents thus derived were used as inputs to the GTD model to determine the gain versus elevation angle of the antennas for HF skywave when situated in the irregular terrain. The surface wave solution for groundwave was not included since this does not appreciably contribute any effect to the skywave far-field patterns at HF in this case. The model predictions were made using perfect electric conducting (PEC) plates and using thin plates made of lossy dielectric material with the same conductivity and relative permittivity as measured for the soil. These computed results were compared with experimental elevation-plane pattern data obtained using a single-frequency helicopter-borne beacon transmitter towed on a long dielectric rope in the far field on a linear path directly over the antennas. The monopoles and dipoles were situated in front of, on top of, and behind a hill whose elevation above the flat surrounding terrain was about 45 m. The patterns of all of the antenna types and sitings exhibited diffraction effects caused by the irregular terrain, with the largest effects being observed at the highest measurement frequency (27 MHz).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
On the Performance of Cell-Free Massive MIMO in Ricean Fading (2018)

We consider an uplink time-division duplex cell-free massive multiple-input multiple-output (MIMO) system in which many user equipments (UEs) are simultaneously served by many access points (APs) via simple matched filtering processing. The propagation channel is modeled via the Ricean distribution, which includes a dominant line-of-sight component on top of diffuse scattering. The Ricean K-factor of each link varies with the UE location (relative to the locations of the APs). The system performance in terms of the spectral efficiency is investigated taking into account imperfect channel knowledge. Power and AP-weighting control is exploited to maximize the lowest spectral efficiency across all UEs. This optimization problem can be efficiently solved via the bisection method by solving a sequence of linear feasibility problems together with the generalized eigen-value problem. We show that by optimally selecting the power control and AP-weighting coefficients, the per-UE throughput increases significantly. Furthermore, we propose an AP selection scheme to reduce the backhaul requirements in a cell-free massive MIMO system, with slight compromise in performance.
Using fault detection methods to optimize parameters in human-machine interface devices (1999)

Using methods from fault diagnosis studies and signal detection theory, an optimal model involving decision making of the human operator is formulated. Parameters are estimated based on a likelihood function methodology to characterize how human responses are elicited. The theoretical model is empirically validated with human subjects and it enables one to estimate certain properties of the human-machine interface (risk adversity).
Catalytic Oxidation of Phenols to p-Quinones with the Hydrogen Peroxide and Methyltrioxorhenium(VII) System (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Oxidation of Phenols to p-Quinones with the Hydrogen Peroxide and Methyltrioxorhenium(VII) SystemWaldemar Adam, Wolfgang A. Herrmann, Jianhua Lin, and Chantu R. Saha-MoellerCite this: J. Org. Chem. 1994, 59, 26, 8281–8283Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://doi.org/10.1021/jo00105a058RIGHTS & PERMISSIONSArticle Views1030Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (348 KB) Get e-Alerts Get e-Alerts
Supplementary Materials and Methods, Supplementary Tables 1 through 4, and Supplementary Figures 1 through 9 from Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2 (2023)

&lt;p&gt;Supplementary Materials and Methods. Supplementary table 1: XRay crystallography parameters for DP-4157/MET complex. Supplementary table 2: Source and description of kinases. Supplementary table 3: Selectivity of profile of altiratinib inhibition from Reaction Biology 295 kinase panel (fold selectivity versus IC50 value of 2.7 nM MET inhibition). Supplementary table 4: A. Inhibition of MET phosphorylation in the MKN-45 xenograft model after a single oral dose of altiratinib (30 mg/kg); B. Inhibition of MET phosphorylation in the MKN-45 xenograft model after a single oral dose of altiratinib (10 mg/kg). Supplementary figure 1: Co-crystal structures of altiratinib analog DP-4157. Supplementary figure 2: Comparison of altiratinib with other clinical stage MET inhibitors regarding potency versus activation loop mutant forms D1228H, D1228N, Y1230D, Y1230C, and Y1230H. Supplementary figure 3: Determination of off-rate, residency time, and tight-binding inhibitor constant Kd for altiratinib binding to the MET kinase domain. Supplementary figure 4: Michaelis-Menton analysis of altiratinib inhibition of MET with respect to ATP. Supplementary figure 5: Kinome tree interaction profile for altiratinib vs 295 human kinases. Altiratinib was evaluated using Kinase HotspotSM platform from Reaction Biology (Malvern, PA). Supplementary figure 6: Inhibitory potencies for inhibiting HUVEC cell signaling activated by HGF/MET (black), VEGF-A/VEGFR2 (melon), and ANG2/TIE2 (tan). Comparative potencies are shown for altiratinib, E-7050, cabozantinib, and MGCD-265. Supplementary figure 7: Upper panel: inhibition of capillary tube formation by various concentrations of altiratinib. Tube formation was initiated by addition of 200 ng/mL of angiopoietin 2 (ANG2). Lower table: titrated IC50 values for inhibition of capillary tube formation induced by ANG2, HGF, and VEGF-A. Supplementary figure 8: Inhibition of proliferation in the mutant B-RAF melanoma SK-MEL-28 cell line in the absence or presence of HGF or MRC-5 fibroblast conditioned medium. Supplementary figure 9: Ratio of brain: plasma concentrations of altiratinib through 24 hr after administration of a single dose of 5 mg/kg IV to C57/Black mice.&lt;/p&gt;
Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing (2015)

Recent studies have shown limited utility of routine surveillance imaging for diffuse large B-cell lymphoma (DLBCL) patients achieving remission. Detection of molecular disease by immunoglobulin high-throughput sequencing (Ig-HTS) from peripheral blood provides an alternate strategy for surveillance. We prospectively evaluated the utility of Ig-HTS within 311 blood and 105 tumor samples from 75 patients with DLBCL, comparing Ig-HTS from the cellular (circulating leukocytes) and acellular (plasma cell-free DNA) compartments of peripheral blood to clinical outcomes and (18)fluoro-deoxyglucose positron emission tomography combined with computed tomography (PET/CT; n = 173). Clonotypic immunoglobulin rearrangements were detected in 83% of patients with adequate tumor samples to enable subsequent monitoring in peripheral blood. Molecular disease measured from plasma, compared with circulating leukocytes, was more abundant and better correlated with radiographic disease burden. Before treatment, molecular disease was detected in the plasma of 82% of patients compared with 71% in circulating cells (P = .68). However, molecular disease was detected significantly more frequently in the plasma at time of relapse (100% vs 30%; P = .001). Detection of molecular disease in the plasma often preceded PET/CT detection of relapse in patients initially achieving remission. During surveillance time points before relapse, plasma Ig-HTS demonstrated improved specificity (100% vs 56%, P < .0001) and similar sensitivity (31% vs 55%, P = .4) compared with PET/CT. Given its high specificity, Ig-HTS from plasma has potential clinical utility for surveillance after complete remission.
Development of novel therapies for gut dysbioses (2016)

This thesis reports results of 30 years of systematic clinical investigations carried out by the author in the general area of “infection-driven inflammation”. The Centre for Digestive Diseases (CDD) endoscopy clinic was founded by the author in 1984 closely coinciding with Drs Barry Marshall and Robin Warren reporting gastric spiral bacteria with pathogenic role in ulcer disease. CDD was able to source gastric biopsies with Helicobacter pylori(HP) from numerous patients with ulcer disease creating the environment necessary for HP research. Hence, Section 1 of the Thesis describes systematic studies which asked questions such as ‘which is the best therapy’, ‘what is the role of acid suppression’ and the ‘role of cigarettes’? This culminated in the development of ‘triple therapy’, the first clinically effective HP cure commercialised later as Helidac.
Success in HP research soon led to the treatment of the candidate infective cause of Crohn’s disease called Mycobacterium avium subspecies paratuberculosis (MAP). This comprised of three antibiotics which were active intracellularly - another ‘triple therapy’ akin to HP treatment. However, curing HP could be achieved in 7 days and ulcer healing in 6 weeks whereas MAP – one of the slowest growing bacterial pathogens – required treatment for many months to heal the bowel. So in Section 2 of the Thesis the effect of Anti-MAP therapy on healing Crohn’s disease was studied. Funding from the Broad Foundation supported culture and PCR of MAP while an Israeli company, RedHill Biopharma has funded current pivotal trials with a view to an FDA approval.
Section 3 of the Thesis describes research in Faecal Microbiota Transplantation (FMT). FMT was first used at CDD in 1988 in a patient with indeterminate colitis - the first patient world-wide treated for colitis and cured. Generally Clostridium difficile infection (CDI) is treated with FMT at CDD with a cure rate exceeding 95%. Subsequently over 6,000 FMT treatments were carried out and new indications for FMT were discovered, both within and outside of the GI tract. These included ulcerative colitis, irritable bowel syndrome, constipation, MS, arthritis, acne, and others, reported in enclosed publications. CDD work in FMT contributed to the global growth of microbiome research and culminated in the creation of the lyophilised encapsulated FMT.
Each of the three Sections has addressed “infection-driven inflammation” in different body regions. It is hoped that reported findings in this Thesis will lead to new therapies that will result in significant clinical improvements.
A New TTL Alignment Method for Optical Lithography System. Chromatic Aberration-Free TTL Alignment Technique Using Two Incident Beams. (1992)

This paper presents a novel TTL (through the lens) alignment method, called SMART (separated marks TTL alignment), for optical lithography system. This alignment optical system could be accomplished without any complicated chromatic aberration compensation mechanisms. It was clarified that the relative displacement between the reticle and the wafer can be directly detected by measuring the intensity change from detector or the phase difference in the optical heterodyne beat signals. It is also demonstrated that the alignment signal is independent from the wafer focus variation, and can always be detected, even during exposure. An alignment signal stabilization method, in which part of the diffraction lights from the reticle marks are used as reference beat signal, has been adapted to obtain high positioning accuracy. As a result, alignment signal variation of less than 12 nm (0.012 ttm) has been obtained.
Evaluation of the In Situ Ichthyoplankton Imaging System (ISIIS): comparison with the traditional (bongo net) sampler (2012)

Plankton and larval fish sampling programs often are limited by a balance between sampling frequency (for precision) and costs. Advancements in sampling techniques hold the potential to add considerable efficiency and, therefore, add sampling frequency to improve precision. We compare a newly developed plankton imaging system, In Situ Ichthyoplankton Imaging System (ISIIS), with a bongo sampler, which is a traditional plankton sampling gear developed in the 1960s. Comparative sampling was conducted along 2 transects ~30–40 km long. Over 2 days, we completed 36 ISIIS tow-yo undulations and 11 bongo oblique tows, each from the surface to within 10 m of the seafloor. Overall, the 2 gears detected comparable numbers of larval fishes, representing similar taxonomic compositions, although larvae captured with the bongo were capable of being identified to lower taxonomic levels, especially larvae in the small (&lt;5 mm), preflexion stages. Size distributions of the sampled larval fishes differed considerably between these 2 sampling methods, with the size range and mean size of larval fishes larger with ISIIS than with the bongo sampler. The high frequency and fine spatial scale of ISIIS allow it to add considerable sampling precision (i.e., more vertical sections) to plankton surveys. Improvements in the ISIIS technology (including greater depth of field and image resolution) should also increase taxonomic resolution and decrease processing time. When coupled with appropriate net sampling (for the purpose of collecting and verifying the identification of biological samples), the use of ISIIS could improve overall survey design and simultaneously provide detailed, process-oriented information for fisheries scientists and oceanographers.
Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units (2016)

Two derivatives of organouranyl mononuclear complexes [UO2(L)THF] (1) and [UO2(L)Alc] (2), where L = (2,2'-(1E,1'E)-(2,2-dimethylpropane-1,3-dyl)bis(azanylylidene, THF = Tetrahydrofuran, Alc = Alcohol), have been prepared. These complexes have been determined by elemental analyses, single crystal X-ray crystallography and various spectroscopic studies. Moreover, the structure of these complexes have also been studied by DFT and time dependent DFT measurements showing that both the complexes have distorted pentagonal bipyramidal environment around uranyl ion. TD-DFT results indicate that the complex 1 displays an intense band at 458.7 nm which is mainly associated to the uranyl centered LMCT, where complex 2 shows a band at 461.8 nm that have significant LMCT character. The bonding has been further analyzed by EDA and NBO. The photocatalytic activity of complexes 1 and 2 for the degradation of rhodamine-B (RhB) and methylene blue (MB) under the irradiation of 500W Xe lamp has been explored, and found more efficient in presence of complex 1 than complex 2 for both dyes. In addition, dye adsorption and photoluminescence properties have also been discussed for both complexes.
Luminescent Silver Clusters with Covalent Functionalization of Graphene (2012)

Brightly luminescent, atomically precise subnanometer clusters of silver protected by glutathione were covalently functionalized by solution phase thiolated graphene using ligand exchange. A hybrid molecule was formed, which was obtained in a nearly pure form by phase transfer from the aqueous to the organic phase. The resulting hybrid exhibited properties of both of these nanoscale materials. UV–vis, luminescence, XPS, EDAX, TEM, and Raman spectroscopy were used to characterize the hybrid structure, which showed the spectroscopic characteristics of both the constituents. The luminescence of the cluster was retained in the hybrid, along with features characteristic of graphene. Atomically precise clusters with covalently linked graphene will be useful for new applications in the areas of drug delivery, sensors, and catalysis.