gebhart/patrepeval huggingface dataset:
Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression (2007)

Precursor cells of the human central nervous system can be cultured in vitro to reveal pathogenesis of diseases or developmental disorders. Here, we have studied the biology of neural precursor cells (NPCs) from patients of lethal congenital contracture syndrome (LCCS), a severe motoneuron disease leading to prenatal death before the 32nd gestational week. LCCS fetuses are immobile because of a motoneuron defect, seen as degeneration of the anterior horn and descending tracts of the developing spinal cord. The genetic defect for the syndrome is unknown. We show that NPCs isolated postmortem from LCCS fetuses grow and are maintained in culture, but display increased cell cycle activity. Global transcript analysis of undifferentiated LCCS precursor cells present with changes in EGF-related signaling when compared with healthy age-matched human controls. Further, we show that LCCS-derived NPCs differentiate into cells of neuronal and glial lineage and that the initial differentiation is not accompanied by overt apoptosis. Cells expressing markers Islet-1 and Hb9 are also generated from the LCCS NPCs, suggesting that the pathogenic mechanism of LCCS does not directly affect the differentiation capacity or survival of the cells, but the absence of motoneurons in LCCS may be caused by a noncell autonomous mechanism.
Ubiquitin-Conjugating Enzyme Ubc13 Is a Critical Component of TRAF-Mediated Inflammatory Responses. (2006)

Abstract Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonical ubiquitination of TRAF-family adapter proteins involved in Toll-like Receptor (TLR) and TNF-family cytokine receptor signaling. Gene ablation was used to study the function of Ubc13 in mice. While homozygous ubc13 gene disruption resulted in embryonic lethality, heterozygous ubc13+/− mice appeared normal without alterations in immune cell populations. Haploinsufficient ubc13+/− mice were resistant to lipopolysaccharide (LPS)-induced lethality, and demonstrated reduced in vivo ubiquitination of TRAF6. Macrophages and splenocytes isolated from ubc13+/− mice exhibited reduced LPS-inducible cytokine secretion and impaired activation of TRAF-dependent signal transduction pathways (NF-kB, JNK, p38 MAPK). These findings document a critical role for Ubc13 in inflammatory responses, and suggest that agents reducing Ubc13 activity could have therapeutic utility.
Hysterectomy Compared With Endometrial Ablation for Dysfunctional Uterine Bleeding (2007)

I.
On the stereoselectivity of the intramolecular dioxenone photocycloaddition (1993)

The stereoselectivity of the intramolecular photocycloaddition of dioxenone and enone substrates is compared. A mechanistic scheme that is consistent with the striking differences in the observed stereoselectivities is presented.
Positive Invariant Sets for Safe Integrated Vehicle Motion Planning and Control (2018)

This paper describes a method for real-time integrated motion planning and control of autonomous vehicles. Our method leverages feedback control, positive invariant sets, and equilibrium trajectories of the closed-loop system to guarantee collision-free closed-loop trajectory tracking. Our method jointly steers the vehicle to a target region and controls the velocity while satisfying constraints associated with the future motion of the obstacles with respect to the vehicle. We develop a receding-horizon implementation and verify the method in a simulated road scenario. The results show that our method generates safe dynamically feasible trajectories while accounting for obstacles in the environment and modeling errors. In addition, the computation times indicate that the method is sufficiently efficient for real-time implementation.
Abstract 891: The chemokine receptor CXCR7 transduces its signal through mTOR: the role of everolimus (2012)

Abstract Everolimus (RAD001, Afinitor) is an mTOR inhibitor FDA-approved for the treatment of patients with advanced clear cell renal cancer (RCC) after failure of treatment with sunitinib or sorafenib, or both drugs. It targets the mammalian target of rapamycin (mTOR) complex inhibiting a serine/threonine kinase regulating PI3K/AKT signaling pathway. Previous evidences demonstrated that the activation of the chemokine receptor CXCR4 involved the mTOR pathway and that CXCR4 was overexpressed in RCC. Recently, also the deorphanized chemokine receptor CXCR7 was described in RCC and defined as an independent prognostic factor. Nevertheless, little is known about the CXCR4-CXCL12-CXCR7-induced signalling. Aim of the study was to investigate if the CXCL12/CXCR4/CXCR7 complex could transduce the signal through mTOR identifying new therapeutic targets. In human renal cancer cells (RXF393, A498) treatment with CXCL12, the CXCR4 and CXCR7 ligand, induced mTOR pathway, as demonstrated through p70S6K and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) induction; the CXCL12 induction is specifically inhibited by AMD3100, a CXCR4 inhibitor, and CCX733, a CXCR7 inhibitor. The inhibition of the mTOR pathway through RAD001 treatment, inhibited CXCL12-induced pERK1/2 and chemotaxis while AMD3100 and CCX733 were not able to inhibit pERK and migration in RXF393 and A498 cell lines suggesting a role of mTOR downstream of CXCR4 and CXCR7. To analyze the CXCR7 transduction pathway the function of p38 kinase, a CXCR7 target, was evaluated. CXCL12 dramatically induced p38 MAPK in cell lines RXF393 and A498 and the p38MAPK induction was specifically inhibited by CCX733, a CXCR7 inhibitory molecule but, interestingly, p38 MAPK is dramatically induced by AMD3100, a CXCR4 antagonist. To further confirm the p38 role downstream of CXCR7, CXCL12 was unable to induce p38 phosphorylation in RXF393 cells CXCR7 siRNA transduced while inhibited by the specific CXCR7 inhibitor CCX733 in RXF393 cells. The treatment with RAD001 in human renal cancer cells inhibited the p38 induction CXCL12-mediated. This is the first evidence demonstrating that p38 is a CXCR7 target in human renal cancer cells and that AMD3100, a specific CXCR4 antagonist, potentiate the CXCL12 activity on CXCR7. Thus the combined inhibition of the three members CXCR4/CXCR7/mTOR is a valid therapeutic strategy to treat RCC inhibiting two cross talking pathways CXCR4-CXCR7 signaling to mTOR. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 891. doi:1538-7445.AM2012-891
SMA wire actuator modular design framework (2009)

Shape memory alloy (SMA) wire actuators are quickly becoming technologically ready for a wider range of commercial applications due both to their exceptional actuation performance and to recent advances in the manufacture of drawn SMA wire. Shape memory alloys are complex materials requiring a breadth and depth of knowledge to successfully implement in more demanding industrial applications, knowledge to which most engineers may not have been exposed. This paper proposes a modular design framework to aid engineers at any level of expertise to synthesize and analyze SMA wire actuators. The modularity of the framework allows for changes in design, architecture, and system topology and allows for easy adaptation to the rapid research advances in the knowledge and understanding of the response and robust use of SMA. The layered structure of the framework is detailed; differentiating the design tasks by function: modeling, evaluation, optimization, and design guidance. Each layer is modular within itself, and in particular, the modeling layer allows for a variety of views to suit the expertise of individual designers. A sample design tool built within the framework is presented for the synthesis of actuators composed of multiple straight SMA wires acting against linear loads, accompanied by a physical system demonstration. This example, while basic, demonstrates the general applicability and flexibility of the framework for aiding many types of users in a large variety of SMA wire actuation design problems.
Proof of Therapeutic Efficacy of a177Lu-Labeled Neurotensin Receptor 1 Antagonist in a Colon Carcinoma Xenograft Model (2017)

Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy. Using the favorable biodistribution data of the NTR1-targeting agent <sup>111</sup>In-3BP-227, we investigated the therapeutic effect of its <sup>177</sup>Lu-labeled analog on the tumor growth of NTR1-positive HT29 colon carcinoma xenografts. <b>Methods:</b> 3BP-227 was labeled with <sup>177</sup>Lu. To assess its biodistribution properties, SPECT and CT scans of HT29-xenografted nude mice injected with <sup>177</sup>Lu-3BP-227 were acquired, and ex vivo tissue activity was determined. To evaluate therapeutic efficacy, 2 groups of mice received the radiopharmaceutical in a median dose of either 165 MBq (129-232 MBq, <i>n</i> = 10) or 110 MBq (82-116 MBq, <i>n</i> = 10), whereas control mice were injected with vehicle (<i>n</i> = 10). Tumor sizes and body weights were monitored for up to 49 d. Renal function and histologic morphology were evaluated. <b>Results:</b> Whole-body SPECT/CT images allowed clear tumor visualization with low background activity and high tumor-to-kidney and -liver ratios. Ex vivo biodistribution data confirmed high and persistent uptake of <sup>177</sup>Lu-3BP-227 in HT29 tumors (19.0 ± 3.6 vs. 2.7 ± 1.6 percentage injected dose per gram at 3 and 69 h after injection, respectively). The application of <sup>177</sup>Lu-3BP-227 resulted in a distinct delay of tumor growth. Median tumor doubling time for controls was 5.5 d (interquartile range [IQR], 2.8-7.0), compared with 17.5 d (IQR, 5.5-22.5 d) for the 110-MBq and 41.0 d (IQR, 27.5-55.0) for the 165-MBg group. Compared with controls, median relative tumor volume at day 23 after injection was reduced by 55% (<i>P</i> = 0.034) in the 110-MBq and by 88% (<i>P</i> < 0.01) in the 165-MBq group. Renal histology and clinical chemistry results did not differ between radiotherapy groups and controls, suggesting absence of therapy-induced acute renal damage. <b>Conclusion:</b> These data demonstrate that the novel NTR1-targeting theranostic agent 3BP-227 is an effective and promising candidate for radioligand therapy, with a favorable preliminary safety profile and high potential for clinical translation.
Forensic analysis for tamper resistant software (2005)

This paper concerns the protection of a software program and/or the content that the program protects. Software piracy and digital media piracy have cost industries billions of dollars each year. The success of the content/software security technologies in a large part depends on the capability of protecting software code against tampering and detecting the attackers who distribute the pirate copies. In this paper, we focus on the attacker detection and forensic analysis. We shall talk about a proactive detection scheme for defeating an on-going attack before the compromise has occurred. We shall also briefly explain another detection scheme for post-compromise attacker identification. In particular, we consider real world scenarios where the application programs connect with their vendors periodically, and where a detection of attacking can bar a hacker user from further business.
Proton NMR study of triantennary complex type N-linked glycan chains: assignment of proton chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAcβ1→6Manα1→6Manβ→sequence (1997)

The chemical shifts of ring protons of the beta-Man residue in a triantennary complex type N-linked glycan chain having a GlcNAc beta 1-->6(GlcNAc beta 1-->2)Man alpha 1-->6 Man beta sequence were unambiguously determined by two-dimensional proton nuclear magnetic resonance (1H-NMR) spectroscopic methods. The chemical shift of H4 (3.84 ppm) of the beta-Man residue was for the first time revealed to be different from those (approximately 3.77 ppm) of biantennary and alternative type of triantennary glycans having a GlcNAc beta 1-->2 Man alpha 1-->6 Man beta sequence, but quite close to that (3.86 ppm) of a pentaantennary glycan containing a GlcNAc beta 1-->6 residue on the Man alpha 1-->6 Man beta sequence. Thus, the addition of GlcNAc beta 1-->6 residue on the Man-4' residue, whose formation is catalyzed by GlcNAc transferase V, is considered to cause a down-field shift of beta-Man H4 in the complex-type N-glycan chains. One possible explanation of this phenomenon is that the conformation of Man alpha 1-->6 arm is folded back toward the proximal core region, as is the case with the complex-type N-glycan chains with the bisecting GlcNAc residue.
Depth extended online RPCA with spatiotemporal constraints for robust background subtraction (2015)

The detection of moving objects is the first step in video surveillance systems. But due to the challenging backgrounds such as illumination conditions, color saturation, and shadows, etc., the state of the art methods do not provide accurate segmentation using only a single camera. Recently, subspace learning model such as Robust Principal Component analysis (RPCA) shows a very nice framework towards object detection. But, RPCA presents the limitations of computational and memory issues due to the batch optimization methods, and hence it cannot process high dimensional data. Recent research on RPCA methods such as Online RPCA (OR-PCA) alleviates the traditional RPCA limitations. However, OR-PCA using only color or intensity features shows a weak performance specially when the background and foreground objects have a similar color or shadows appear in the background scene. To handle these challenges, this paper presents an extension of OR-PCA with the integration of depth and color information for robust background subtraction. Depth is less affected by shadows or background/foreground color saturation issues. However, the foreground object may not be detected when it is far from the camera field as depth is less useful without color information. We show that the OR-PCA including spatiotemporal constraints provides accurate segmentation with the utilization of both color and depth features. Experimental evaluations on a well-defined benchmark dataset with other methods demonstrate that our proposed technique is a top performer using color and range information.
Synthese des ersten Methylidin-Rhodium-Clusters durch säureinduzierte H2/CH4-Eliminierung aus einem μ-Methylen-Komplex (1980)

Die Umwandlung eines μ-Methylen-dirhodium-Komplexes in einen μ3-Methylidin-trirhodium-Komplex (Röntgen-Strukturanalyse) gelang am Beispiel (1)→(3). Erster Schritt ist die Protonierung von (1) zum (isolierbaren) μ-Hydrido-Komplex (2).
Organization of Motor Proteins into Functional Micropatterns Fabricated by a Photoinduced Fenton Reaction (2009)

Das selektive Zerstören von Nitrilotriessigsäure-Einheiten an einer Polyethylenglycol-Polymerbürste durch eine lichtinduzierte Fenton-Reaktion ermöglichte es, Motorproteine in funktionelle Mikromuster zu organisieren (siehe schematische Darstellung). Mikrotubuli wurden von diesen Strukturen selektiv eingefangen, und ein Adenosintriphosphat-abhängiger Transport entlang von Linien wurde beobachtet.
Supplementary Table 12 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors (2023)

&lt;p&gt;Supplementary Table 12: Cox regression analyses of the effect of mosaic chromosomal alterations on the risk of death of cardiovascular disease causes per cancer type&lt;/p&gt;
Neuromorphic Computing: Tailoring the Switching Dynamics in Yttrium Oxide‐Based RRAM Devices by Oxygen Engineering: From Digital to Multi‐Level Quantization toward Analog Switching (Adv. Electron. Mater. 11/2020) (2020)

For neuromorphic computing that mimics the human brain, digital memory has to turn analogue. A key scientific question is how to teach materials to adopt synaptic plasticity. In article 2000439, Stefan Petzold, Eszter Piros, and co-workers use the novel technique of oxygen engineering on yttrium oxide and show that this particular material is a prominent candidate to allow for controlling and fine-tuning switching dynamics.
Prevalence, Epidemiology, Etiology, and Sensitivity of Invasive Bacterial Infections in Pediatric Patients Undergoing Oncological Treatment: A Multicenter Nationwide Study (2020)

<b><i>Background:</i></b> Infectious complications (IC) caused by bacterial strains often impede anticancer therapy. The study aimed to retrospectively analyze bacterial IC that could help predict the risk and optimize the empirical treatment for bacterial infections in pediatric cancer patients. <b><i>Patients and Methods:</i></b> Over a 72-month period, all-in 5,599 children with cancer: 2,441 patients with hematological malignancy (HM including acute leukemias, Hodgkin and non-Hodgkin lymphomas [NHLs], and Langerhans cell histiocytosis) and 3,158 with solid tumors (STs including central nervous system tumors, neuroblastoma, Wilms' tumor, soft tissue sarcoma, germ cell tumors, Ewing sarcoma, osteosarcoma, hepatoblastoma, and others) were enrolled into the study. Episodes of bacterial infectious complications (EBICs) confirmed by microbiological findings were reported by each hospital and analyzed centrally. <b><i>Results:</i></b> At least 1 EBIC was diagnosed in 2,155 (36.8%) children (1,281 [59.4%] with HM and 874 [40.6%] with ST; <i>p</i> < 0.001). All-in 4,860 EBICs were diagnosed including 62.2% episodes in children with HM and 37.8% in children with ST (<i>p</i> < 0.001). Having analyzed the source of infections, blood stream infections predominated, apart from NHL patients in whom the most common type was gut infections. The profile of bacteria strains was different in HM and ST groups (<i>p</i> < 0.001). However, in both groups the most common Gram-negative pathogen was Enterobacteriaceae, with the rate being higher in the HM group. Among Gram-negative strains low susceptibility to ceftazidime, whereas among <i>Enterococcus</i> spp. low susceptibility to vancomycin was noticed. The rate of multidrug-resistant (MDR) pathogens was high, especially for Gram negatives (47.7% vs. 23.9%; <i>p</i> < 0.001). The survival after infections was comparable for HM and ST patients (<i>p</i> = 0.215). <b><i>Conclusions:</i></b> The risk of bacterial IC in HM patients was higher than in the ST group. The high rate of MDR strains was detected in pediatric cancer patients, especially in those with HM.
Rate-constraining changes in surface properties, porosity and hydrolysis kinetics of lignocellulose in the course of enzymatic saccharification (2016)

Although a hydrolysis-dependent increase of non-productive binding capacity of lignin was not apparent, the dependence of hydrolysis maxima on the enzyme dosage was best explained by partial irreversible product inhibition. Cellulose surface area correlated with the total cellulose content, which is thus an appropriate approximation of the substrate concentration for kinetic modelling. Kinetic models of cellulose hydrolysis should be simplified enough to include reversible and irreversible product inhibition and reduction of hydrolysability, as well as their possible non-linear relations to hydrolysis degree, without overparameterization of particular factors.
Comparison of Performance of Virtual Coupling Schemes for Haptic Collaboration using Real and Emulated Internet Connections (2007)

Networked haptic virtual environments (NHVEs) are those in which multiple users collaborate and experience force feedback at the same time. The robustness of such systems needs to be tested under various network conditions that closely mirror the Internet. Previously, we had proposed three virtual c
Policy-based NFV management and orchestration (2015)

Softwarization of network functions running on commodity servers, switches, and storage by leveraging standard IT virtualization and cloud technologies has become a goal of communications service providers (CSPs). Management and orchestration (MANO) is crucial for achieving this network functions virtualization (NFV) vision. We propose an open platform for NFV that exposes APIs that can be consumed by other components of a MANO framework. This Enhanced Network Cloud Platform (ENCP) is based on a common policy-based framework. It employs a network appliance container (NAC) as an abstraction of a network function, and it uses predictive and proactive analytics for elasticity and virtual resource management. The architecture of ENCP is presented, and its prototype implementation is discussed.
Observation of separated dynamics of charge and spin in the Fermi-Hubbard model (2020)

Strongly correlated quantum systems give rise to many exotic physical phenomena, including high-temperature superconductivity. Simulating these systems on quantum computers may avoid the prohibitively high computational cost incurred in classical approaches. However, systematic errors and decoherence effects presented in current quantum devices make it difficult to achieve this. Here, we simulate the dynamics of the one-dimensional Fermi-Hubbard model using 16 qubits on a digital superconducting quantum processor. We observe separations in the spreading velocities of charge and spin densities in the highly excited regime, a regime that is beyond the conventional quasiparticle picture. To minimize systematic errors, we introduce an accurate gate calibration procedure that is fast enough to capture temporal drifts of the gate parameters. We also employ a sequence of error-mitigation techniques to reduce decoherence effects and residual systematic errors. These procedures allow us to simulate the time evolution of the model faithfully despite having over 600 two-qubit gates in our circuits. Our experiment charts a path to practical quantum simulation of strongly correlated phenomena using available quantum devices.