gebhart/patrepeval huggingface dataset:
ALTERATIONS IN BLOOD VOLUME FOLLOWING SHORT TERM, HIGH INTENSITY EXERCISE (1982)

Thomson, J. A.; Green, H. J.; Hughson, R. L.; Ball, M. E.; Houston, M. E.; Sharratt, M. T. Author Information
Supplementary Figure and Table Legends from Somatic <i>ERCC2</i> Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma (2023)

Supplementary Figure and Table Legends from Somatic &lt;i&gt;ERCC2&lt;/i&gt; Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
To see the unseeable: confocal miniprobes for routine microscopic imaging during endoscopy (2007)

Confocal fluorescence high resolution imaging during standard endoscopic procedures has been presented as a very promising tool to enhance patient care and physician practice by providing supplementary diagnostic information in real-time. The purpose of this paper is to show not only potential, but convincing results of endoscopic microscopy using a catheter-based approach. Mauna Kea Technologies' core technology, Cellvizio, delivers dynamic imaging at 12 frames/second using confocal miniprobes inserted through the operating channel of regular endoscopes. Cellvizio is composed of 3 parts including (a) a Laser Scanning Unit, (b) Confocal Miniprobe<sup>TM</sup> with the following characteristics: 5-15 &mgr;m axial resolution, 2-5 &mgr;m lateral resolution, 15-100 &mgr;m depth of penetration, field of view of 600x500 &mgr;m and (c) a software package with onthe- fly processing capabilities. With several tens of patients examined during routine GI endoscopy procedures, the most relevant clinical parameters could be assessed in a doubled-blinded fashion between the endoscopist and a pathologist and results showing very high accuracy in the differentiation of neoplasia from normal and hyperplastic tissue were obtained. In the field of pulmonology, the micro-autofluorescence properties of tissues could be assessed and structures never before accessed in vivo were observed. Cellvizio® may be useful to study bronchial remodeling in asthma and chronic obstructive pulmonary diseases. Using appropriate topical fluorescent dye, the Confocal Miniprobes may also make it possible to perform optical biopsy of precancerous and superficial bronchial cancers. Cellvizio® is as a new tool towards "targeted biopsies", leading to earlier, more reliable and cost effective diagnostic procedures. Other applications, specifically in molecular imaging are also made possible by the miniaturization of the probe (combination with biopsy needle for solid organs use or lymph node detection) and by the compatibility of the system with other imaging modalities (auto-fluorescence and narrow-band imaging endoscopy, MRI, PET, etc).
Full field modelling of recrystallization in superalloys thanks to level-set method (2014)

International audience
IgE‐cross‐blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1 (2021)

Our mechanistic approach suggested that immunotherapy with the reference allergen Bet v 1 induces individual repertoires of cross-reactive IgG1 and IgG4 antibodies. The cross-blocking bioactivity of these antibodies was also highly variable and neither predictable from protein homology nor IgE-cross-reactivity.
Inverse design engineering of all-silicon polarization beam splitters (2016)

Utilizing the inverse design engineering method of topology optimization, we have realized high-performing all-silicon ultra-compact polarization beam splitters. We show that the device footprint of the polarization beam splitter can be as compact as ~2 μm<sup>2</sup> while performing experimentally with a polarization splitting loss lower than ~0.82 dB and an extinction ratio larger than ~15 dB in the C-band. We investigate the device performance as a function of the device length and find a lower length above which the performance only increases incrementally. Imposing a minimum feature size constraint in the optimization is shown to affect the performance negatively and reveals the necessity for light to scatter on a sub-wavelength scale to obtain functionalities in compact photonic devices.
Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study (2016)

This pilot study suggests that supplementing C-section born neonates with low-dose B. lactis-containing starter formula may impact immune as well as gut maturation similarly to regular-dose B. lactis, close to the breast-feeding reference.
Scalable Fabrication and Use of 3D Structured Microparticles Spatially Functionalized with Biomolecules (2021)

Microparticles with defined shapes and spatial chemical modification can interface with cells and tissues at the cellular scale. However, conventional methods to fabricate shaped microparticles have trade-offs between the throughput of manufacture and the precision of particle shape and chemical functionalization. Here, we achieved scalable production of hydrogel microparticles at rates of greater than 40 million/hour with localized surface chemistry using a parallelized step emulsification device and temperature-induced phase-separation. The approach harnesses a polymerizable polyethylene glycol (PEG) and gelatin aqueous two-phase system (ATPS) which conditionally phase separates within microfluidically generated droplets. Following droplet formation, phase separation is induced and phase separated droplets are subsequently cross-linked to form uniform crescent and hollow shell particles with gelatin functionalization on the boundary of the cavity. The gelatin localization enabled deterministic cell loading in subnanoliter-sized crescent-shaped particles, which we refer to as nanovials, with cavity dimensions tuned to the size of cells. Loading on nanovials also imparted improved cell viability during analysis and sorting using standard fluorescence activated cell sorters, presumably by protecting cells from shear stress. This localization effect was further exploited to selectively functionalize capture antibodies to nanovial cavities enabling single-cell secretion assays with reduced cross-talk in a simplified format.
ChemInform Abstract: Pure Polymorph C of Zeolite Beta Synthesized by Using Framework Isomorphous Substitution as a Structure‐Directing Mechanism. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P-fimbriae-producing septicaemic Escherichia coli from poultry possess fel-related gene clusters whereas pap-hybridizing P-fimbriae-negative strains have partial or divergent P fimbrial gene clusters (1996)

The organization of P fimbrial gene clusters of 13 papC-hybridizing Escherichia coli strains isolated from poultry with colisepticaemia, five P-fimbriae-expressing (P-positive) and eight P-fimbriae-non-expressing (P-negative), were examined by PCR and by Southern blot hybridization using primers or gene probes specific to the I, B, A, C or G genes. The absence of P fimbrial expression was associated with lack of PCR amplification of one or more of these genes, most commonly the I gene. Restriction endonuclease EcoRI, BamHI or PstI digests of genomic DNA from all strains hybridized with each of the gene probes and demonstrated polymorphisms between P-positive and P-negative strains. PstI digests of DNA from 12 of the 13 strains, when hybridized with the A gene probe, demonstrated a 0.1 kb fragment specific to the felA gene which encodes the major structural protein of F11 fimbriae. Hence, only the P-positive strains contained complete copies of fel-related gene clusters. In contrast, most of the pap-hybridizing P-negative strains contained partial or divergent P fimbrial gene clusters, which explains the lack of P fimbrial expression by these strains.
ChemInform Abstract: Δ3‐ISOPENTENYL METHYL SULFIDE. A NEW TERPENOID IN THE SCENT MARK OF THE RED FOX (VULPES VULPES) (1979)

Abstract 3‐Methyl‐3‐butenol (Ia) wird in das Tosylat (Ib) umgewandelt und dann mit Lithiummethylmercaptid (II) zum Thioether (III) substituiert.
Perceived frailty and measured frailty among adults undergoing hemodialysis: a cross-sectional analysis (2015)

Perceived frailty is an inadequate proxy for measured frailty among patients undergoing hemodialysis.
Taxonomy of breast cancer based on normal cell phenotype predicts outcome (2014)

Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, a classification scheme based on the phenotypic similarity between tumor cells and normal cells has been successfully used to define tumor subtypes; however, use of normal cell types as a reference by which to classify solid tumors has not been widely emulated, in part due to more limited understanding of epithelial cell differentiation compared with hematopoiesis. To provide a better definition of the subtypes of epithelial cells comprising the breast epithelium, we performed a systematic analysis of a large set of breast epithelial markers in more than 15,000 normal breast cells, which identified 11 differentiation states for normal luminal cells. We then applied information from this analysis to classify human breast tumors based on normal cell types into 4 major subtypes, HR0-HR3, which were differentiated by vitamin D, androgen, and estrogen hormone receptor (HR) expression. Examination of 3,157 human breast tumors revealed that these HR subtypes were distinct from the current classification scheme, which is based on estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Patient outcomes were best when tumors expressed all 3 hormone receptors (subtype HR3) and worst when they expressed none of the receptors (subtype HR0). Together, these data provide an ontological classification scheme associated with patient survival differences and provides actionable insights for treating breast tumors.
The NF‐κB binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells (2013)

Thymic stromal lymphopoietin (TSLP) is constitutively secreted by intestinal epithelial cells. It regulates gut DCs, therefore, contributing to the maintenance of immune tolerance. In the present report, we describe the regulation of TSLP expression in intestinal epithelial cells and characterize the role of several NF-κB binding sites present on the TSLP promoter. TSLP expression can be stimulated by different compounds through activation of p38, protein kinase A, and finally the NF-κB pathway. We describe a new NF-κB binding element located at position -0.37 kb of the promoter that is crucial for the NF-κB-dependent regulation of TSLP. We showed that mutation of this proximal NF-κB site abrogates the IL-1β-mediated transcriptional activation of human TSLP in several epithelial cell lines. We also demonstrated that both p65 and p50 subunits are able to bind this new NF-κB binding site. The present work provides new insight into epithelial cell-specific TSLP regulation.
Complete Solid State13C NMR Chemical Shift Assignments for α-D-Glucose, α-D-Glucose-H2O and β-D-Glucose (1984)

Abstract NMR spectra of crystalline α-D-glucose DH2O (1), α-D-glucose (2), and β-D-glucose (3) were examined by 13C cross polarization magic angle spinning (CPMAS) methods. Each of the three forms of glucose exhibited a distinctly different spectrum. Chemical interconversion of 2 and 3 as well as the in situ dehydration of 1 during the course of the CPMAS NMR experiment was monitored in the 13C spectra. Samples of 1, 2, and 3 specifically enriched at C-1 and C-6 with 13C yielded 13C spectra in which the resonances corresponding to the adjacent C-2 and C-5 carbons were not visible due to strong homonuclear 13C dipolar interactions with the high abundance label. Spectra of these analogues as well as the C-2 and C-3 labeled materials provided the complete 13C chemical shift assignments of crystalline 1 2, and 3. A comparison of the solid state and solution 13C spectra revealed substantial resonance shifts for each of the three structures examined.
Designing for persistent audio conversations in the enterprise (2007)

Social media websites like flickr and del.icio.us enable collaboration by allowing users to easily share content on the web through tagging. To provide a similar advantage to the enterprise, we have designed a tagging system for audio conversations. We are developing telephonic interfaces, where participants of a spoken conversation can opt to archive and share it. We have also developed a web-based visual interface that enables annotation, search, and retrieval of archived conversations. In this interface, we have focused on visualizing relationships between users, tags and conversations, which will enable efficient searching and browsing, and more importantly, provide contextualized interaction histories. A pilot user study, conducted using simulated data, showed that our social network visualization was effective.
ChemInform Abstract: Hydrogen‐Free Alkene Reduction in Continuous Flow. (2013)

Abstract A H 2 ‐free continuous flow hydrogenation protocol is presented.
Mitochondrial respiration reduces exposure of the nucleus to oxygen (2023)

The endosymbiotic theory posits that ancient eukaryotic cells engulfed O<sub>2</sub>-consuming prokaryotes, which protected them against O<sub>2</sub> toxicity. Previous studies have shown that cells lacking cytochrome c oxidase (COX), required for respiration, have increased DNA damage and reduced proliferation, which could be improved by reducing O<sub>2</sub> exposure. With recently developed fluorescence lifetime microscopy-based probes demonstrating that the mitochondrion has lower [O<sub>2</sub>] than the cytosol, we hypothesized that the perinuclear distribution of mitochondria in cells may create a barrier for O<sub>2</sub> to access the nuclear core, potentially affecting cellular physiology and maintaining genomic integrity. To test this hypothesis, we utilized myoglobin-mCherry fluorescence lifetime microscopy O<sub>2</sub> sensors without subcellular targeting ("cytosol") or with targeting to the mitochondrion or nucleus for measuring their localized O<sub>2</sub> homeostasis. Our results showed that, similar to the mitochondria, the nuclear [O<sub>2</sub>] was reduced by ∼20 to 40% compared with the cytosol under imposed O<sub>2</sub> levels of ∼0.5 to 18.6%. Pharmacologically inhibiting respiration increased nuclear O<sub>2</sub> levels, and reconstituting O<sub>2</sub> consumption by COX reversed this increase. Similarly, genetic disruption of respiration by deleting SCO2, a gene essential for COX assembly, or restoring COX activity in SCO2<sup>-/-</sup> cells by transducing with SCO2 cDNA replicated these changes in nuclear O<sub>2</sub> levels. The results were further supported by the expression of genes known to be affected by cellular O<sub>2</sub> availability. Our study reveals the potential for dynamic regulation of nuclear O<sub>2</sub> levels by mitochondrial respiratory activity, which in turn could affect oxidative stress and cellular processes such as neurodegeneration and aging.
The perceived brightness of a flash can be influenced by temporal properties of its neighbors (2010)

The perceived brightness of an object depends on the spatial relationships it has with its neighbors (e.g., brightness induction). We examined whether perceived brightness of a briefly flashed object depends on its temporal relationships with its neighbors. Two gray disks were flashed on either side of a fixation point: one flash lasted for 14 ms (‘brief’); the other lasted for 500 ms (‘long’). Observers reported which flash appeared brighter. When the flashes had simultaneous onset against a dark background, subjects report the brief flash dimmer than the long flash, consistent with the Broca-Sulzer effect. However, when the flashes had simultaneous offset, the brief flash now appeared brighter. The perceived brightness of the brief flash increased monotonically and non-linearly with increasing SOA. When the background was made higher luminance than the flashes, results were reversed: now an onset-matched brief flash appeared brighter, an offset-matched brief flash appeared dimmer. When two brief flashes are presented — one aligned with onset, the other with offset of the long flash — a comparison between them bares the same result: the onset-matched flashed is seen as dimmer than the offset-matched flash. Our results suggest that brightness properties of the brief flashes are temporally integrated with the background, and that the integration time window can be shortened by a salient offset signal nearby. Consistent with this explanation, the differential effect was lost when the flashes were isoluminant with a colored background. We present a model of the neural substrate underlying this phenomenon. Further, we ask whether we are aware of certain kinds of brightness changes, or instead only are aware of the result of integrations over these changes. Our results indicate that we are aware of integrations, and that the duration of the integration window may be changed by salient temporal events in neighboring locations in the visual scene.
Optimizing a Hybrid Energy Storage System for a Virtual Power Plant for Improved Wind Power Generation: A Case Study for Denmark (2011)

This paper describes one approach to find two optimum energy storages (ESs) to build a hybrid system which is part of a virtual power plant. Here it means the combination of the hybrid energy storage system and wind power plant (WPP). The<br/>discussed approach is applied in a case study on the power market in western Denmark. The optimum ESs are selected based on the highest net present value (NPV) out of many different combinations of ESs in terms of power rating and technologies. Due to its many possible combinations a simulation model has been built which uses historical market data and also the latest available price data for ESs.
A Set of Activators and Repressors Control Peripheral Glucose Pathways in Pseudomonas putida To Yield a Common Central Intermediate (2008)

Pseudomonas putida KT2440 channels glucose to the central Entner-Doudoroff intermediate 6-phosphogluconate through three convergent pathways. The genes for these convergent pathways are clustered in three independent regions on the host chromosome. A number of monocistronic units and operons coexist within each of these clusters, favoring coexpression of catabolic enzymes and transport systems. Expression of the three pathways is mediated by three transcriptional repressors, HexR, GnuR, and PtxS, and by a positive transcriptional regulator, GltR-2. In this study, we generated mutants in each of the regulators and carried out transcriptional assays using microarrays and transcriptional fusions. These studies revealed that HexR controls the genes that encode glucokinase/glucose 6-phosphate dehydrogenase that yield 6-phosphogluconate; the genes for the Entner-Doudoroff enzymes that yield glyceraldehyde-3-phosphate and pyruvate; and gap-1, which encodes glyceraldehyde-3-phosphate dehydrogenase. GltR-2 is the transcriptional regulator that controls specific porins for the entry of glucose into the periplasmic space, as well as the gtsABCD operon for glucose transport through the inner membrane. GnuR is the repressor of gluconate transport and gluconokinase responsible for the conversion of gluconate into 6-phosphogluconate. PtxS, however, controls the enzymes for oxidation of gluconate to 2-ketogluconate, its transport and metabolism, and a set of genes unrelated to glucose metabolism.
Dual-Polarization Multi-Band OFDM versus Single-Carrier DP-QPSK for 100 Gbps Long-Haul WDM Transmission over Legacy Infrastructure (2012)

We experimentally compare the performance of coherent dual-polarization multi-band OFDM (DP-MB-OFDM) and QPSK (DP-QPSK) for 100 Gbps long-haul transport over legacy infrastructure combining G.652 fiber and 10 Gbps WDM system. We show that DP-MB-OFDM and DP-QPSK have nearly the same performance at 100 Gbps after transmission over a 10×100 km fiber line.
Competitive Science: Is Competition Ruining Science? (2015)

In the winner-take-all economics of science, scientists compete for priority, the recognition that they are the first to make a discovery, conferring prestige that, in turn, can lead to employment, funding, prizes, and membership in honorific societies. It is often taken for granted that this competitiveness is beneficial because it provides incentives for individuals to excel. It has also suggested that scientific rivalries can provide a corrective for confirmation bias, the tendency to favor evidence that supports one's preexisting beliefs. Thus, in theory, competition may help to protect science from stagnation and dogma.
Efficient Photoelectrochemical Solar Cells Equipped with an n‐Si Electrode Modified with Colloidal Platinum Particles (1994)

Various platinum (Pt) colloid solutions were prepared and used for the modification of n‐type silicon (n‐Si) electrodes. All the photoelectrochemical (PEC) solar cells, equipped with the Pt‐colloid modified n‐Si electrodes thus prepared, gave the open‐circuit photovoltages of 0.550 to 0.630 V, much higher than those for n‐Si electrodes coated with continuous thin Pt layers, clearly showing the beneficial effect of the discontinuous metal coating. The PEC cells, equipped with the textured‐surface n‐Si electrodes modified with the Pt colloid particles prepared by Bredig's method, yielded an energy conversion efficiency of 14.9% in a three‐electrode configuration. The relation between the and the size and distribution of the Pt particles is discussed.
Alterations of lipid metabolism in Wilson disease (2011)

Contradictory to previous reports using WD animal models (Atp7b-/- and LEC rats), the most obvious alteration in our cohort was a lower serum cholesterol level in hepatic-affected patients, which might be related to liver injury. Our data suggested unimpaired cholesterol metabolism in Wilson disease under therapy, independent of the applied medical treatment.
Room Temperature Reduction of Nitrogen Oxide to Nitrogen on MetalOrganic Frameworks (2020)

Air pollution is an epochal concern, particularly in urban areas, and is linked to combustion processes 1 . The emission of nitrogen oxides (NOx) constitutes a critical environmental problem, and it can affect severely human health2,3,4 . At ambient temperature and pressure NOx decomposition is thermodynamically favoured; however, this process is kinetically inhibited, owing to a high activation energy5,6 . To date, no reported catalysts have had the required properties to lower the activation energy of this process without the help of coreacting agents and high temperatures7,8,9 . Here, we show that NO conversion to molecular nitrogen can be achieved at room temperature in the presence of O2 and H2O vapour, and in the absence of any further reducing agent, using iron-based Metal-Organic Frameworks (MOFs). Further, we demonstrate that MOFs work similarly to enzymes, but are stable in environments unfriendly to living matter. These findings open large perspectives on the solution of stringent problems in chemistry, such as the removal of pollutants or the activation of highly stable molecules.