gebhart/patrepeval huggingface dataset:
Application of microtrap-GC for continuous monitoring of organic emissions from a catalytic incinerator (1999)

In the last few years we have reported the development of a microtrap for the dual purpose of concentration and injection in continuous gas chromatography (GC) monitoring of air emissions. Microtrap-GC exhibits low detection limits, is functionally simple, and can be operated automatically. In this article we report its application in on-line monitoring of trace level organic emissions from a catalytic incinerator which is a widely used emission control device. The microtrap has been configured in two different ways; in a sequential valve microtrap (SVM) mode where it is connected in series with a gas sample valve and in a back-flush desorption mode referred to as the on-line microtrap backflush (OLMT-BF). ©1999 John Wiley & Sons, Inc. J Micro Sep 11: 239–245, 1999
Dynamic buffer overflow detection for GPGPUs (2017)

Buffer overflows are a common source of program crashes, data corruption, and security problems. In this work, we demonstrate that GPU-based workloads can also cause buffer overflows, a problem that was traditionally ignored because CPUs and GPUs had separate memory spaces. Modern GPUs share virtual, and sometimes physical, memory with CPUs, meaning that GPU-based buffer overflows are capable of producing the same program crashes, data corruption, and security problems as CPU-based overflows. While there are many tools to find buffer overflows in CPU-based applications, the shift towards GPU-enhanced programs has expanded the problem beyond their capabilities. This paper describes a tool that uses canaries to detect buffer overflows caused by GPGPU kernels. It wraps OpenCL™ API calls and alerts users to any kernel that writes outside of a memory buffer. We study a variety of optimizations, including using the GPU to perform the canary checks, which allow our tool to run at near application speeds. The resulting runtime overhead, which scales with the number of buffers used by the kernel, is 14% across 175 applications in 16 GPU benchmark suites. In these same suites, we found 13 buffer overflows in 7 benchmarks.
An automated N-port network analyzer for linear and non linear multi-port RF and digital circuits (2002)

A new automated N-port time and frequency domain network analyzer based on the microwave transition analyzer MTA, used as a high speed digital oscilloscope, has been developed. The validity of the developed system is demonstrated with number of experimental measurements on different multi-ports structures.
Accelerated and motion‐robust in vivo T2 mapping from radially undersampled data using bloch‐simulation‐based iterative reconstruction (2015)

The presented MSE data-processing framework offers reliable mapping of T2 relaxation values in a ∼ 5-minute timescale, free of user- and scanner-dependent variations. The use of radial k-space sampling provides further advantages in the form of high immunity to irregular physiological motion, as well as enhanced spatial resolutions, owing to its inherent ability to perform alias-free limited field-of-view imaging.
Data from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some leukemias, the ultimate challenge remains the eradication of large solid tumors for most cancers. We aimed to develop an immunotherapy approach effective against large tumors in an immunocompetent, self-antigen preclinical mouse model.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; In this study, we generated dual-specific T cells expressing both a CAR specific for Her2 and a TCR specific for the melanocyte protein (gp100). We used a regimen of adoptive cell transfer incorporating vaccination (ACTIV), with recombinant vaccinia virus expressing gp100, to treat a range of tumors including orthotopic breast tumors and large liver tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; ACTIV therapy induced durable complete remission of a variety of Her2&lt;sup&gt;+&lt;/sup&gt; tumors, some in excess of 150 mm&lt;sup&gt;2&lt;/sup&gt;, in immunocompetent mice expressing Her2 in normal tissues, including the breast and brain. Vaccinia virus induced extensive proliferation of T cells, leading to massive infiltration of T cells into tumors. Durable tumor responses required the chemokine receptor CXCR3 and exogenous IL2, but were independent of IFNγ. Mice were resistant to tumor rechallenge, indicating immune memory involving epitope spreading. Evidence of limited neurologic toxicity was observed, associated with infiltration of cerebellum by T cells, but was only transient.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This study supports a view that it is possible to design a highly effective combination immunotherapy for solid cancers, with acceptable transient toxicity, even when the target antigen is also expressed in vital tissues. &lt;i&gt;Clin Cancer Res; 23(10); 2478–90. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A pragmatic approach to computer-aided assembly planning (2002)

A pragmatic approach to computer-aided assembly planning is presented. The formalism used to analyze the product is described. It is shown that the first step is one of the most important: the product model must contain all the necessary information. Then, with the help of the product analysis, the planner must determine feasible operational plans. The assembly planner is discussed along with the formalism used to describe the assembly plans. Results are presented and discussed on the basis of a case study.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inhibition of cyclooxygenase‐2 impairs the expression of essential plasma cell transcription factors and human B‐lymphocyte differentiation (2009)

Cyclooxygenase (Cox) inhibitors are among the most widely used and commonly prescribed medications. Relatively little is understood about their influence on human immune responses. Herein, we discovered a novel and important mechanism whereby non-steroidal anti-inflammatory drugs (NSAIDs) blunt human B-cell antibody production. We demonstrate that the Cox-2 selective small molecule inhibitors SC-58125 and NS-398 attenuate the production of human antibody isotypes including immunoglobulin M (IgM), IgG1, IgG2, IgG3 and IgG4. In addition, inhibition of Cox-2 significantly reduced the generation of CD38+ IgM+ and CD38+ IgG+ antibody-secreting cells. Interestingly, we discovered that inhibition of Cox-2 activity in normal human B cells severely reduced the messenger RNA and protein levels of the essential plasma cell transcription factor, Blimp-1. These observations were mirrored in Cox-2-deficient mice, which had reduced CD138+ plasma cells and a near loss of Blimp-1 expression. These new findings demonstrate a critical role for Cox-2 in the terminal differentiation of human B lymphocytes to antibody-secreting plasma cells. The use of NSAIDs may adversely influence the efficacy of vaccines, especially in the immunocompromised, elderly and when vaccines are weakly immunogenic.
NASICON-based CO<sub>2</sub> Sensor Operative at Room Temperature Using Li<sub>2</sub>CO<sub>3</sub>-BaCO<sub>3</sub> Auxiliary Phase (2003)

A solid state CO2 sensor operative at room temperature, developed by incorporating a metal oxide sensing electrode and a metal carbonate auxiliary phase into a NASICON (Na3Zr2Si2PO12)-based electrochemical cell, suffers from a humidity-dependent shift of the EMF response to CO2. In an attempt to reduce the humidity dependence, binary carbonate systems of Li2CO3-BaCO3 and Na2CO3-BaCO3 at various compositions were tested for the auxiliary phase of the device. The melting-and-quenching method conventionally used for attaching the carbonate was not applicable well to the present type device due to the corrosion of NASICON surface. The humidity-least dependent device could be obtained when the Li2CO3-BaCO3 composite (1:2 in molar ratio) was adhered to NASICON by calcination at 500°C (non melting method). The device could respond to 300-3000 ppm CO2 quite well almost independent of relative humidity (RH) beyond 30%. In the lower range of RH, however, the EMF response commenced to shift and the CO2 sensing capability was completely lost in the dry atmosphere. A planar type CO2 sensor was fabricated successfully, which could work stably under the conditions of 30% RH and above.
An adaptive quasi linear representation-a generalization of multiscale edge representation (2005)

The analysis of the discrete multiscale edge representation is considered. A general signal description called an inherently bounded adaptive quasi linear representation (AQLR), motivated by two important examples (the wavelet maxima representation and the wavelet zero-crossings representation) is introduced. The questions of uniqueness, stability, and reconstruction are addressed. It is shown that the dyadic wavelet maxima (zero-crossings) representation is, in general, nonunique. These representations are always stable. A reconstruction algorithm, based on the minimization of an appropriate cost function, is proposed. The convergence of the algorithm is guaranteed for all inherently bounded AQLR. In the case of the wavelet transform, this method yields an efficient parallel algorithm, especially promising in an analog-hardware implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Maximizing the right stuff: The trade-off between membrane permeability and selectivity (2017)

Filtering through to what's important Membranes are widely used for gas and liquid separations. Historical analysis of a range of gas pair separations indicated that there was an upper bound on the trade-off between membrane permeability, which limits flow rates, and the selectivity, which limits the quality of the separation process. Park et al. review the advances that have been made in attempts to break past this upper bound. Some inspiration has come from biological membranes. The authors also highlight cases where the challenges lie in areas other than improved separation performance. Science , this issue p. eaab0530
DRACO (2014)

Draco [Kazi et al. 2014] is a sketch-based interface that allows artists and casual users alike to add a rich set of animation effects to their drawings, seemingly bringing illustrations to life. While previous systems have introduced sketch-based animations for individual objects, our contribution is a unified framework of motion controls that allows users to seamlessly add coordinated motions to object collections. From an interface design perspective, the key challenge to this problem is to formulate a general framework for workflow and controls that is easy to use, but expressive enough to author a wide range of dynamic phenomena.
Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[β-11C]DOPA (2006)

The regional distribution of K corresponds to that of the nigrostriatal and mesolimbic dopaminergic system. Negative correlation between neutral amino acid concentration and K1 supports the suggestion that L-DOPA is transported in a competitive fashion via the same carrier system as neutral amino acids at the blood-brain barrier. Because the graphical approach can obviate the need for an arterial input function, it is useful for investigating the rate of regional dopamine synthesis in neuropsychiatric and neurodegenerative diseases.
Study Of Mordenite Zsm-5 And Nay Zeolites,Containing Cr, Cs, Zn, Ni, Co, Li, Mn, To Control Hydrocarbon Cold-Start Emission (2011)

The implementation of Super-Ultra Low Emission Vehicle standards requires more efficient exhaust gas purification. To increase the efficiency of exhaust gas purification, an the adsorbent capable of holding hydrocarbons up to 250-300 ОС should be developed. The possibility to design such adsorbents by modification of zeolites of mordenite type, ZSM-5 and NaY, using different metals cations has been studied. It has been shown that introducing Cr, Cs, Zn, Ni, Co, Li, Mn in zeolites results in modification of the toluene TPD and toluene sorption capacity. 5%LiZSM-5 zeolite exhibits the most attractive TPD curve, with toluene desorption temperature ranging from 250 to 350ОС. The sorption capacity of 5%Li-ZSM-5 is 0.4 mmol/g. NaY zeolite has the highest sorption capacity, up to 2 mmol/g, and holds toluene up to 350ОС, but at 120ОС toluene desorption starts, which is not desirable, since the adsorbent of cold start hydrocarbons should retain them until 250-300ОС. Therefore 5%LiZSM-5 zeolite was found to be the most promising to control the cold-start hydrocarbon emissions among the samples studied.
Placental Alkaline Phosphatase as a Tumor Marker for Seminoma (1983)

No AccessJournal of Urology1 Dec 1983Placental Alkaline Phosphatase as a Tumor Marker for Seminoma P.H. Lange, J.L. Millan, T. Stigbrand, R.L. Vessella, E. Ruoslahti, and W.H. Fishman P.H. LangeP.H. Lange More articles by this author , J.L. MillanJ.L. Millan More articles by this author , T. StigbrandT. Stigbrand More articles by this author , R.L. VessellaR.L. Vessella More articles by this author , E. RuoslahtiE. Ruoslahti More articles by this author , and W.H. FishmanW.H. Fishman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51781-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Placental Alkaline Phosphatase as a Tumor Marker for Seminoma." The Journal of Urology, 130(6), pp. 1250–1251 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130Issue 6December 1983Page: 1250-1251 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P.H. Lange More articles by this author J.L. Millan More articles by this author T. Stigbrand More articles by this author R.L. Vessella More articles by this author E. Ruoslahti More articles by this author W.H. Fishman More articles by this author Expand All Advertisement PDF downloadLoading ...
Pattern Collapse of High-Aspect-Ratio Silicon Nanostructures - A Parametric Study (2016)

This work focuses on capillary-induced collapse of high-aspect-ratio silicon nanopillars. Modification of the surface chemistry is demonstrated to be an efficient approach for reducing capillary forces and consequently reduce pattern collapse. Special effort is spent on determination of the wetting state of chemically modified surfaces as complete structure wetting is of utmost importance in wet processing. In light of this, an ATR-FTIR based method has been developed to unambiguously distinguish between wetting and non-wetting states.
Seamless Joining of Silicon Nitride Ceramics (2001)

High‐strength joining of Si 3 N 4 ceramics has been achieved by developing a process that effectively eliminates the seam, and may allow for fabrication of large or complex silicon nitride bodies. This approach to joining is based on the concept that when sintering aids are effective in bonding individual grains, they could be equally effective in joining bulk pieces of Si 3 N 4 . Optimization of the process led to Si 3 N 4 /Si 3 N 4 joints with room‐temperature bend strengths as high as 950 MPa, corresponding to more than 90% of the bulk strength of the Si 3 N 4 . At elevated temperatures of 1000° and 1200°C joint strengths of 666 and 330 MPa, respectively, were obtained, which are the highest values reported to date for these temperatures. These bend strengths are also more that 90% of the strength of bulk Si 3 N 4 measured at these temperatures.
Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A‐mediated phospholamban phosphorylation in diabetic rats (2004)

1. The goal of this study was to elucidate the possible mechanisms by which protein kinase A (PKA)-mediated regulation of the sarcoplasmic reticulum (SR) via phospholambin protein phosphorylation is functionally impaired in streptozotocin-induced diabetic rats. 2. Phospholamban (PLB) protein and mRNA levels were 1.3-fold higher in diabetic than in control hearts, while protein expression of cardiac SR Ca(2+)-ATPase (SERCA2a) was unchanged. 3. Basal and isoprenaline-stimulated phosphorylation of PLB at Ser(16) or Thr(17) was unchanged in diabetic hearts. However, stronger immunoreactivity was observed at the basal level in diabetic hearts when antiphosphoserine antibody was used. 4. Basal (32)P incorporation into PLB was significantly higher in diabetic than in control SR vesicles, but the extent of the PKA-mediated increase in PLB phosphorylation was the same in the two groups of vesicles. 5. Stimulation of Ca(2+) uptake by PKA-catalyzed PLB phosphorylation was weaker in diabetic than in control SR vesicles. The PKA-induced increase in Ca(2+) uptake was attenuated when control SR vesicles were preincubated with protein kinase C (PKC). 6. PKC activities were increased by more than two-fold in the membranous fractions from diabetic hearts in comparison with control values, regardless of whether Ca(2+) was present. This was associated with increases in the protein content of PKCdelta, PKCeta, PKCiota, and PKClambda in diabetic membranous fractions. 7. The changes observed in diabetic rats were reversed by insulin therapy. 8. These results suggest that PKA-dependent phosphorylation may incompletely counteract the function of PLB as an inhibitor of SERCA2a activity in diabetes in which PKC expression and activity are enhanced.
Linoleic Acid-Based Transferosomes for Topical Ocular Delivery of Cyclosporine A (2022)

Delivering high-molecular-weight hydrophobic peptides, such as cyclosporine A, across the corneal epithelium remains a challenge that is complicated by other physio-anatomical ocular structures that limit the ocular bioavailability of such peptides. Transferosomes have previously been used to improve transdermal permeability, and have the potential for improving the ocular corneal permeability of applicable drugs. In this study, transferosomes for the potential ocular delivery of cyclosporine A were investigated. Linoleic acid was evaluated for its effect on the stability of the transferosomes and was substituted for a portion of the cholesterol in the vesicles. Additionally, Span<sup>®</sup> 80 and Tween<sup>®</sup> 80 were evaluated for their effect on transferosome flexibility and toxicity to ocular cells as edge activators. Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATF-FTIR), differential scanning calorimetry (DSC), and dynamic light scattering (DLS) were used to evaluate the physicochemical parameters of the blank and the cyclosporine A-loaded transferosomes. Cyclosporine A release and corneal permeability were studied in vitro and in a New Zealand albino rabbit corneal model, respectively. The linoleic acid contributed to improved stability and the nano-size of the transferosomes. The Tween<sup>®</sup>-based formulation was preferred on the basis of a more favorable toxicity profile, as the difference in their corneal permeability was not significant. There was an initial burst release of cyclosporine A in the first 24 h that plateaued over one week. The Tween<sup>®</sup>-based formulation had a flux of 0.78 µg/cm<sup>2</sup>/h. The prepared transferosomes demonstrated biocompatibility in the ocular cell line, adequately encapsulated cyclosporine A, ensured the corneal permeability of the enclosed drug, and were stable over the period of investigation of 4 months at -20 °C.
The IBM 2011 GALE Arabic speech transcription system (2011)

We describe the Arabic broadcast transcription system fielded by IBM in the GALE Phase 5 machine translation evaluation. Key advances over our Phase 4 system include a new Bayesian Sensing HMM acoustic model; multistream neural network features; a MADA vowelized acoustic model; and the use of a variety of language model techniques with significant additive gains. These advances were instrumental in achieving a word error rate of 7.4% on the Phase 5 evaluation set, and an absolute improvement of 0.9% word error rate over our 2009 system on the unsequestered Phase 4 evaluation data.
The Magnitude of Perceptual Learning is Equated when Stimuli are Scaled According to Cortical Magnification Factor (2012)

Practice helps improve performance on a variety of visual tasks. Previous studies have shown that the magnitude of these improvements is inversely proportional to initial levels of performance, with subjects who perform more poorly at the start tending to improve most during perceptual training. If initial performance levels determine the absolute magnitude of learning, it follows that equating performance at the start of training should lead to equivalent amounts of learning. Here we test this prediction by comparing learning on an abutting Vernier alignment task with stimuli presented at two retinal eccentricities (5 and 15 deg) equated in terms of either retinal size (unscaled stimuli) or cortical size (scaled stimuli). Prior to learning, unscaled stimuli produced larger alignment thresholds at the more peripheral eccentricity, whereas scaled stimuli produced equivalent alignment thresholds. Consistent with previous work, we found that the magnitude of learning for participants who trained over eight daily sessions with the unscaled stimuli (n=11) was significantly larger at 15 than 5 degrees eccentricity. However, when stimuli were spatially scaled (n=11), we found equivalent amounts of learning at each location. These data suggest differences in the magnitude of learning can be accounted for by differences in the cortical representation of stimuli. Cortical scale may set not only the initial performance level but also the upper limit for the magnitude of performance improvements following training.
Regions where transient signals are influenced between a source and receiver (2006)

At infinite frequency, a medium only influences the waveform of a received signal emitted from a source along one or more infinitesimally thin rays. For transient signals at finite frequencies, an exact method is developed to compute the regions in a medium that significantly influence the received signal for any specified window of signal travel time. Results are (1) in homogeneous media, a significant portion of the signal originates from waves that traverse paths that are approximately integer and half-integer numbers of cycles greater than the straight path between source and receiver. Called ‘‘constructive and destructive paths of influence,’’ they do not obey Fermat’s principle of path stationarity. (2) For reflection from a flat interface in a homogeneous medium, the received signal is significantly influenced by constructive and destructive paths of influence whose angles of incidence and reflection differ. (3) Near 100 Hz in an oceanic waveguide, the region of influence markedly departs from a ray. Near upper turning points, the influential region is flat for O(10) km instead of O(1) km for a ray. (4) The first Fresnel zone is an inappropriate scale to characterize the region of influence for transient signals near a steep ray in inhomogeneous media.