gebhart/patrepeval huggingface dataset:
The Stereochemistry of the Thermal Decomposition of Viylic Copper(I) and Silver(I) Organometallic Compounds1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereochemistry of the Thermal Decomposition of Viylic Copper(I) and Silver(I) Organometallic Compounds1George M. Whitesides and Charles P. CaseyCite this: J. Am. Chem. Soc. 1966, 88, 19, 4541–4543Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://doi.org/10.1021/ja00971a067RIGHTS & PERMISSIONSArticle Views326Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (420 KB) Get e-Alertsclose Get e-Alerts
ChemInform Abstract: Carbocyclic Amino Ketones by Bredt′s Rule‐Arrested Kulinkovich—de Meijere Reaction. (2016)

Abstract The direction of the Ti‐mediated intramolecular reaction of amide with alkene depends on the structure of the substrate.
Subsonic Jet Noise Reduction Variable Geometry Chevron (2004)

Turbulent mixing of jet engine exhaust streams contributes significantly to airport community noise. Serrated aerodynamic devices along the trailing edge of exhaust nozzles, known as chevrons, have been shown to greatly reduce jet noise by promoting advantageous mixing of the streams. The design of these devices represents a delicate compromise between noise reduction at take off conditions, engine operability, and thrust loss at cruise. We report here the successful design and test of a full-scale variable geometry chevron for the fan-nozzle exhaust whose shape change is driven by a shape memory alloy actuator. The collected data supports the aerodynamic, thermal, and mechanical modeling of the chevron. The test results demonstrate that the device can operate autonomously and can reproducibly transition between take-off and cruise shapes. Having validated the concept, this data will facilitate the development of the next generation, variable geometry chevron.
The development of Alzheimer's disease in Down's syndrome assessed by auditory event‐related potentials (1988)

Several studies have reported changes in auditory event-related potentials in patients with Alzheimer's type dementia. These include an increase in latency and a reduction in amplitude of the P300 (P3) response, a late positive component generated about 300 ms after an unexpected stimulus. Alzheimer's type dementia is an almost invariable acompaniment of ageing in Down's syndrome. This study was designed to assess the usefulness of the auditory P300 response as a measure of the onset of dementia in Down's subjects, who because of poor language development may be difficult to assess by psychological tests. Auditory event-related potentials were recorded from 89 Down's subjects, aged 16-66 years. A control group of 29 mentally retarded subjects with fragile-X syndrome and 83 normal volunteer controls were also tested. Clinical psychological testing found evidence of dementia in 16 Down's subjects and none with fragile-X. Furthermore, in the Down's population but not the fragile-X or control groups, there was a marked increase in P300 latency with age starting around 37 years. In controls, the effect of age on P300 latency became significant some 17 years later around the age of 54 years. The premature effect of age on P300 in Down's syndrome was due to the prolonged P300 latency in the 16 subjects showing signs of dementia. It was confirmed that P300 latency increase reflects the development of Alzheimer's dementia in Down's subjects.
Correlation of Ultra-low Shear Rate Viscosity and Dynamic Barite Sag in Invert-Emulsion Drilling Fluids (1999)

Abstract The occurrence of barite sag has been a well recognized, but poorly understood phenomenon in the drilling industry. Problems such as lost circulation, well control and stuck pipe have resulted from the occurrence of barite sag. The financial impact of barite sag on drilling costs, usually resulting from rig-time lost while circulating and conditioning the mud system, is not trivial. There are reported incidences where recurring barite sag problems have resulted in the loss of drilling projects. Although originally thought to occur under static conditions, barite sag is now recognized to occur more readily under dynamic, low shear rate conditions. Industry experts have offered a variety of measuring parameters, based upon empirical data, that only partially correlate with the occurrence of barite sag. The prediction of barite sag in dynamic flow has created an engineering challenge. The effect of shear rate on dynamic barite sag, for invert-emulsion muds, has been studied and quantified using new and advanced technology. A new field viscometer, capable of measuring viscosity at shear rates of 0.0017 s-1, and an eccentric well-bore hydraulics model were used to develop and understand this relationship. Changes in mud weight as a function of shear rate, hole angle, annular velocity and eccentricity correlate with ultra-low shear rate viscosity. Based upon experimental results, field technology has been developed to predict the potential for barite sag of invert-emulsion muds and to provide remedial measures through ultra-low shear rate viscosity modification. The efficacy of using traditional rheological measurements as indicators of barite sag potential are addressed.
Seven days ex vivo perfusion of whole ewe ovaries with follicular maturation and oocyte retrieval: towards the development of an alternative fertility preservation method (2022)

Fertility preservation methods for prepubertal women about to undergo gonadotoxic chemo and/or radiation therapy are limited. Therefore, the aim of this study was to investigate the feasibility to develop an alternative fertility preservation method based on an ex vivo perfusion platform for whole ewe ovaries. Thirteen ewe ovaries were divided into two groups (group 1 and 2) that were perfused in a bioreactor for up to 7days. Group 1 (n =3) were stimulated with human menopausal gonadotropin (hMG) administered in single daily dose, while group 2 (n =10) were stimulated continuously for 24h. The perfused ovaries in group 1 showed no significant differences in follicular density, sub-follicular morphology and oocyte quality after ischaemia and after ex vivo perfusion compared with non-perfused control ovaries. The perfused ovaries in group 2 showed a significant decrease in the follicular reserve and oocyte quality compared with the control group. In total, 16 GV-MI oocytes were retrieved from both groups. This study describes for the first time the ex vivo maintenance of viable follicles of ewe ovaries with oocyte integrity and the retrieval of oocytes after ex vivo hormonal perfusion with two different protocols for up to 7days.
Realization and Modeling of Metamaterials Made of rf Superconducting Quantum-Interference Devices (2013)

We have prepared meta-atoms based on radio-frequency superconducting quantum-interference devices (rf SQUIDs) and examined their tunability with dc magnetic field, rf current, and temperature. rf SQUIDs are superconducting split-ring resonators in which the usual capacitance is supplemented with a Josephson junction, which introduces strong nonlinearity in the rf properties. We find excellent agreement between the data and a model that regards the Josephson junction as the resistively and capacitively shunted junction. A magnetic field tunability of 80 THz=G at 12 GHz is observed, a total tunability of 56% is achieved, and a unique electromagnetically induced transparency feature at intermediate excitation powers is demonstrated for the first time. An rf SQUID metamaterial is shown to have qualitatively the same behavior as a single rf SQUID with regard to dc flux and temperature tuning.
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study (2016)

The chemical cross-linking of β-cyclodextrin (β-CD) with ethylenediaminetetraacetic dianhydride (EDTA) led to branched polymers referred to as cyclodextrin nanosponges (CDNSEDTA). Two different preparations are described with 1:4 and 1:8 CD-EDTA molar ratios. The corresponding cross-linked polymers were contacted with 0.27 M aqueous solution of ibuprofen sodium salt (IP) leading to homogeneous, colorless, drug loaded hydrogels. The systems were characterized by high resolution magic angle spinning (HR-MAS) NMR spectroscopy. Pulsed field gradient spin echo (PGSE) NMR spectroscopy was used to determine the mean square displacement (MSD) of IP inside the polymeric gel at different observation times td. The data were further processed in order to study the time dependence of MSD: MSD = f(td). The proposed methodology is useful to characterize the different diffusion regimes that, in principle, the solute may experience inside the hydrogel, namely normal or anomalous diffusion. The full protocols including the polymer preparation and purification, the obtainment of drug-loaded hydrogels, the NMR sample preparation, the measurement of MSD by HR-MAS NMR spectroscopy and the final data processing to achieve the time dependence of MSD are here reported and discussed. The presented experiments represent a paradigmatic case and the data are discussed in terms of innovative approach to the characterization of the transport properties of an encapsulated guest within a polymeric host of potential application for drug delivery.
Flow control for multiple access queues (2001)

We study the problem of finding a characterization for the channel that results when a queue is operated under multiple access conditions. In such systems, the mechanism by which different sources gain access to the channel plays a fundamental role in defining what is the channel available to each source. In this paper therefore we study the structure and properties of these control devices in some detail. Under some (mild) technical conditions, and under modeling assumptions inspired by TCP/IP's flow control (the standard control algorithm in the current Internet), we are able to characterize the optimal controller for this problem. We also present some numerical simulations, to help develop an intuition on what exactly this control box does.
Quantitative Separation of Pd(II) by TLC of Metal Ions on Cerium (IV) Antimonate (1985)

Abstract A quantitative TLC separation of metal ions using cerium (IV) antimonate as the solid phase are described. Using an acetonitrile- HNO3 solvent Pb2+ can be separated quantitatively (2–10 μg) from several other ions. A quantitative spectrophotometric assay using p-nitroso-dimethylaniline is proposed. Key Words: TLCMetal IonsCerium Antimonate
ATM Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer (2020)

Alterations in DNA damage response (DDR) genes are common in advanced prostate tumors and are associated with unique genomic and clinical features. ATM is a DDR kinase that has a central role in coordinating DNA repair and cell-cycle response following DNA damage, and <i>ATM</i> alterations are present in approximately 5% of advanced prostate tumors. Recently, inhibitors of PARP have demonstrated activity in advanced prostate tumors harboring DDR gene alterations, particularly in tumors with <i>BRCA1/2</i> alterations. However, the role of alterations in DDR genes beyond <i>BRCA1/2</i> in mediating PARP inhibitor sensitivity is poorly understood. To define the role of <i>ATM</i> loss in prostate tumor DDR function and sensitivity to DDR-directed agents, we created a series of <i>ATM</i>-deficient preclinical prostate cancer models and tested the impact of <i>ATM</i> loss on DNA repair function and therapeutic sensitivities. <i>ATM</i> loss altered DDR signaling, but did not directly impact homologous recombination function. Furthermore, <i>ATM</i> loss did not significantly impact sensitivity to PARP inhibition but robustly sensitized to inhibitors of the related DDR kinase ATR. These results have important implications for planned and ongoing prostate cancer clinical trials and suggest that patients with tumor <i>ATM</i> alterations may be more likely to benefit from ATR inhibitor than PARP inhibitor therapy. SIGNIFICANCE: ATM loss occurs in a subset of prostate tumors. This study shows that deleting ATM in prostate cancer models does not significantly increase sensitivity to PARP inhibition but does sensitize to ATR inhibition.<i>See related commentary by Setton and Powell, p. 2085</i>.
Shaping ultrafast laser inscribed optical waveguides using a deformable mirror (2008)

We use a two-dimensional deformable mirror to shape the spatial profile of an ultrafast laser beam that is then used to inscribe structures in a soda-lime silica glass slide. By doing so we demonstrate that it is possible to control the asymmetry of the cross section of ultrafast laser inscribed optical waveguides via the curvature of the deformable mirror. When tested using 1.55 mum light, the optimum waveguide exhibited coupling losses of approximately 0.2 dB/facet to Corning SMF-28 single mode fiber and propagation losses of approximately 1.5 dB.cm(-1). This technique promises the possibility of combining rapid processing speeds with the ability to vary the waveguide cross section along its length.
Numerical modeling of thermal refraction in liquids in the transient regime (1999)

We present the results of modeling of nanosecond pulse propagation in optically absorbing liquid media. Acoustic and electromagnetic wave equations must be solved simultaneously to model refractive index changes due to thermal expansion and/or electrostriction, which are highly transient phenomena on a nanosecond time scale. Although we consider situations with cylindrical symmetry and where the paraxial approximation is valid, this is still a computation-intensive problem, as beam propagation through optically thick media must be modeled. We compare the full solution of the acoustic wave equation with the approximation of instantaneous expansion (steady-state solution) and hence determine the regimes of validity of this approximation. We also find that the refractive index change obtained from the photo-acoustic equation overshoots its steady-state value once the ratio between the pulsewidth and the acoustic transit time exceeds a factor of unity.
Abstract 2093: Next-gen deep sequencing improves FGFR3 mutation detection in the urine of bladder cancer patients (2012)

Abstract FGFR3 mutations have been identified in ∼60-70% of low-stage, non-invasive tumors. Our group and others have developed assays to detect FGFR3 mutations in the urine of bladder cancer patients. However, urine-based assays have been limited by the technical ability to detect rare events in a dilute medium where there is a high background of normal DNA. In these assays, FGFR3 mutations are generally found in ∼30% of the urine samples, which is &amp;lt; 50% concordance with the expected detection in tissue. We have now developed an ultra-deep amplicon sequencing technique that increases FGFR3 mutation detection in urine to ∼67%, near the expected detection if every mutation found in tissue could be detected in urine. Amplicons were designed against FGFR3 exons 7, 10, and 15 using PCR primers containing the adapter sequences for unidirectional sequencing. Taqman probes were used to determine if sufficient DNA was present in each sample. Primary amplification was performed from DNA isolated from 4 ml of urine. The resulting PCR products were used as template for emulsion PCR and these were then sequenced using the Roche 454 GS Junior. Samples were analyzed for total DNA reads per sample and number of mutant sequencing reads to determine percent mutation. Urine samples from 29 patients with stage Ta bladder cancer were analyzed by both our previously described qPCR method and the new ultra-deep sequencing approach. Of the 29 samples, 2 did not have sufficient DNA for analysis by sequencing. Using ultra-deep amplicon sequencing, 18 out of 27 (66.7%) were positive for FGFR3 mutations, while only 3 out of 27 (11.1%) were positive for mutations by qPCR. The urine samples from the 15 newly identified mutations using deep sequencing contained FGFR3 mutations as low as 0.05%. Using matched tissue and urine samples, we demonstrate that the sensitivity in urine approximates the FGFR3 mutations observed in tissue. We have developed a highly sensitive non-invasive urine based assay that can detect FGFR3 mutant DNA when present at &amp;lt; 1% of the sample and that achieves &amp;gt; 90% concordance with tumor tissues. To our knowledge, this is the first practical application of next generation sequencing technology for diagnostic use. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2093. doi:1538-7445.AM2012-2093
In vivo molecular contrast optical coherence tomography for vasculature imaging and increased molecular specificity (2013)

We present a novel Pump-Probe Optical Coherence Tomography (PPOCT) system, capable of imaging both methylene blue and hemoglobin simultaneously. In vivo images of Zenopus tadpole vasculature were obtained using hemoglobin as the contrast agent.
Development and Characterisation of Phenolic Resin Based Liquid Silicon Infiltrated SiC/SiC Composites with SiN<sub>x</sub> Fibre Coating (2015)

SiC/SiC ceramics consist of silicon carbide fibres embedded in a silicon carbide matrix. As an alternative to classic CVI and PIP routes, Liquid Silicon Infiltration (LSI) was chosen as a technique with short process times to obtain composites with low porosity. Silicon carbide composites show good thermal shock resistance, a low coefficient of thermal expansion and excellent physical and chemical stability at elevated temperatures and are therefore regarded as promising candidates for various applications in jet engines and in power engineering. To build up the matrix, different phenolic resin based carbon precursors were infiltrated in fibre preforms and thermally cured, pyrolysed and siliconized. The aim is to obtain a high carbon yield during pyrolysis and to control the pore morphology in a way that the following liquid silicon infiltration leads to a complete reaction of the carbon matrix with silicon to SiC. The siliconization behaviour and conversion into SiC in dependence of pore morphology and chosen precursor is analysed.At the same time a functional fibre coating has to be developed which protects the fibres from liquid silicon and simultaneously provides a weak fibre matrix bonding. A LPCVD-SiN x fibre coating has been chosen and is investigated in fibre composites especially in terms of protection and reactivity in different atmospheres during pyrolysis and siliconization.
Directivity and Axial Ratio Distribution of Orbital Angular Momentum Vortex Waves based on Circular Planar Yagi Antenna Array and Sequential Phase Shift (2020)

This paper presents the far-field characteristics of vortex wave of orbital angular momentum (OAM) with circular array antenna. Planar quasi yagi-uda antenna of 8 elements are arranged in circular array and folded into a hollow cylinder. The OAM radio beam can be generated by changing the sequential phase shift of antenna element inputs for each OAM mode number. A full-wave electromagnetic simulator is used to design circular array antenna and to observe distribution of directivity and axial ratio. The depicted results provide insight for the vortex wave radiation.
Insulin resistance is associated with esophageal varices in alcoholic liver disease patients (2016)

Insulin resistance is associated with the presence of esophageal varices, suggesting that the presence of insulin resistance could be harmful to alcoholic liver disease patients.
Comparison of fibrin-based clot elasticity parameters measured by free oscillation rheometry (ReoRox ® ) versus thromboelastometry (ROTEM ® ) (2015)

ReoRox(®) Fibscreen2 test has a high coefficient of variation, and its application in various hemodilution conditions showed limited comparability with the ROTEM(®) FIBTEM test.
(Trifluoromethyl)lumazine Derivatives as 19F NMR Probes for Lumazine protein (1994)

Lumazine protein acts as an electronic excited state transducer in bioluminescence of Photobacterium species. The protein binds 6,7-dimethyl-8-(D-ribityl)lumazine (1) which serves as the fluorophore. This compound also serves as a biosynthetic precursor of riboflavin and is the substrate of the enzyme riboflavin synthase. This enzyme and lumazine protein show considerable sequence homology. The interaction of lumazine apoprotein with several trifluoromethyl analogs of 6,7-dimethyl-8-ribityllumazine was investigated by 19F NMR spectroscopy. Upon binding to the protein, the 19F NMR resonances of the ligand shift to lower field with broadened line widths to around 30 Hz. By comparison, all ligands studied show more complex NMR spectra when bound to riboflavin synthase. Only one position 7 epimer (designated epimer A) of 6,7-bis(trifluoromethyl)-7-hydroxy-8-(D-ribityl)lumazine binds to lumazine apoprotein and riboflavin synthase. The apoprotein can also bind lumazine derivatives with a quarternary C-7. It is suggested that the binding site of lumazine protein corresponds to the donor binding site of riboflavin synthase.
Comparison of soft and hard-switching effiency in a three-level single phase 60kW dc-ac converter (2003)

Efficiency measurements on a three-level single-phase soft-switched converter are presented and show a slightly improved efficiency compared with the hard-switched converter for output powers higher than 25 % of rated power. The resonant converter switches are Zero Voltage Switched (ZVS) and a simple resonant circuit is used. Increased resonant converter efficiency enables a reduction in the semiconductor size pr. watt output power or an increase the switching frequency.
Reengineering the Signaling Properties of a Src Family Kinase (2009)

Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replacing the SH2 and SH3 domains of Hck with the syntrophin PDZ domain. In some constructs, the negative regulatory tyrosine in the C-terminal tail was also replaced with a PDZ ligand sequence. When expressed in mammalian cells, the substrate specificity of the PDZ-kinases was directed to a different group of proteins than wild-type Hck. The PDZ-kinases phosphorylate neuronal nitric oxide synthase (nNOS), a known binding partner of the syntrophin PDZ domain. We also introduced a PDZ ligand at the C-terminus of the adaptor protein Cas. PDZ-Hck kinases phosphorylate the engineered Cas protein in Cas(-/-) cells and restore the migration defect of these cells. A PDZ-kinase was also functional in rewiring MAPK signaling via an engineered ErbB2 construct containing a PDZ ligand sequence. Several of the PDZ-kinases show autoregulatory properties similar to natural SFKs. Thus, the PDZ-ligand interaction is able to functionally replace the normal SH2-pY527 interaction that regulates SFKs. Our data highlight the modularity and evolvability of signaling proteins.