gebhart/patrepeval huggingface dataset:
Probing Coupled Electronic and Nuclear Dynamics Using Coherent Electrons and X-rays (2009)

I will present three studies in which the coupled electronic and nuclear dynamics in molecules are probed using high harmonic generation (HHG), HHG-based ultrashort x-ray laser and strong field ionization.
New application of liquid crystal lens of active polarized filter for micro camera (2012)

Liquid-crystal (LC) lens with low-voltage (3.5V) driving is reported with the experimental results of lens power, wavefront aberration, storage test and also the imaging test. Optical quality can be estimated by interference pattern under two polarizer plates set with the crossed Nichol position, and the optical quality is certified by the measurement of wavefront aberration. Durable stability of over 1000 hours under continuous driving in high temperature (85°C) environment is also verified and obtained less-damaged interference patterns. Finally a new application of active polarized filter for micro camera with focus control function is reported with sufficient quality of images.
Enhancement of the thermoelectric properties of PEDOT:PSS thin films by post-treatment (2013)

In this work, the thermoelectric (TE) properties of poly(3,4-ethylenedioxylthiophene):poly(styrene sulfonate) (PEDOT:PSS) thin films at room temperature are studied. Different methods have been applied for tuning the TE properties: 1st addition of polar solvent, dimethyl sulfoxide (DMSO), into the PEDOT:PSS solution; 2nd post-treatment of thin films with a mixture of DMSO and ionic liquid, 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF4). It is verified that DMSO post-treatment is more efficient than DMSO addition in improving the electrical conductivity with a trivial change in the Seebeck coefficient. The power factor is increased up to 30.1 μW mK−2 for the film with DMSO post-treatment, while the optimized power factor by DMSO addition is 18.2 μW mK−2. It is shown that both DMSO addition and post-treatment induce morphological changes: an interconnected network of elongated PEDOT grains is generated, leading to higher electrical conductivity. In contrast, for those films post-treated in the presence of EMIMBF4, an interconnected network of short and circular PEDOT grains with increased polaron density is created, resulting in the improvement in the Seebeck coefficient and a concomitant compromise in the electrical conductivity. An optimized power factor of 38.46 μW mK−2 is achieved at 50 vol% of EMIMBF4, which is the highest reported so far for PEDOT:PSS thin films to our knowledge. Assuming a thermal conductivity of 0.17 W mK−1, the corresponding ZT is 0.068 at 300 K. These results demonstrate that post-treatment is a promising approach to enhance the TE properties of PEDOT:PSS thin films. Furthermore, ionic liquid, EMIMBF4, shows the potential for tuning the TE properties of PEDOT:PSS thin films via a more environmentally benign process.
Aircore microstructure fibers with suppressed higher-order modes (2006)

A strategy for suppressing higher-order modes in aircore bandgap fibers is proposed. Simulations confirm that significant suppression of unwanted modes is achieved by including index-matched air-guiding structures in the cladding. Suppressing higher-order modes offers to improve the fundamental loss limit in aircore fibers, addressing a key obstacle to the development of this technology.
Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity. (1988)

Glucose cycling (GC G " G6P) equals 14% of glucose produc- tion in postabsorptive man. Our aim was to determine glucose cycling in six lean and six overweight mild type II diabetics (fasting glycemia: 13910 and 1527 mg/dl), in postabsorp- tive state (PA) and during glucose infusion (2 mg/kg per min). 14 control subjects were weight and age matched. GC is a function of the enzyme that catalyzes the reaction opposite the net flux and is the difference between hepatic total glucose output (HTGO) (2-[3Hlglucose) and hepatic glucose produc- tion (HGP) (6-13HJ-glucose). Postabsorptively, GC is a func- tion of glucokinase. With glucose infusion the flux is reversed (net glucose uptake), and GC is a function of glucose 6-phos- phatase. In PA, GC was increased by 100% in lean (from 0.250.07 to 0.43.08 mg/kg per min) and obese (from 0.220.05 to 0.500.07) diabetics. HGP and HTGO in- creased in lean and obese diabetics by 41 and 33%. Glucose infusion suppressed apparent phosphatase activity and gluco- neogenesis much less in diabetics than controls, resulting in marked enhancement (400%) in HTGO and HGP, GC re- mained increased by 100%. Although the absolute responses of C-peptide and insulin were comparable to those of control sub- jects, they were inappropriate for hyperglycemia. Peripheral insulin resistance relates to decreased metabolic glucose clear- ance (MCR) and inadequate increase of uptake during glucose infusion. We conclude that increases in HGP and HTGO and a decrease of MCR are characteristic features of mild type II diabetes and are more pronounced during glucose infusion. There is also an increase in hepatic GC, a stopgap that controls changes from glucose production to uptake. Postabsorptively, this limits the increase of HGP and glycemia. In contrast, during glucose infusion, increased GC decreases hepatic glu- cose uptake and thus contributes to hyperglycemia. Obesity per se did not affect GC. An increase in glucose cycling and turnover indicate hepatic insulin resistance that is observed in addition to peripheral resistance. It is hypothesized that in pathogenesis of type II diabetes, augmented activity of glu- cose-6-phosphatase and kinase may be of importance. 1 .
Rapid and Efficient Synthesis of 1H‐Indol‐2‐yl‐1H‐quinolin‐2‐ones. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
An Efficient Procedure for Traceless Solid-Phase Synthesis of N,N‘-Substituted Thioureas by Thermolytic Cleavage of Resin-Bound Dithiocarbamates (1999)

A novel and efficient procedure which is compatible with high-throughput process for the traceless solid-phase synthesis of thioureas is described. In the presence of carbon disulfide, Merrifield resin reacts with an amine to give a resin-bound dithiocarbamate moiety. Heating this supported dithiocarbamate in the presence of a second amine at 60 degrees C for 12 h led to the formation of the thiourea with the release of benzylthiol bound to the resin. This process allows the preparation of N,N'-di- and trisubstituted thioureas in good yields and with satisfactory purity. Furthermore, the mild reaction conditions involved are compatible with many functional groups.
Using Embedded Dynamic Random Access Memory to Reduce Energy Consumption of Magnetic Recording Read Channel (2010)

Although the performance of a magnetic recording read channel can be improved by employing advanced iterative signal detection and coding techniques, the method nevertheless tends to incur significant silicon area and energy consumption overhead. Motivated by recent significant improvement of high-density embedded dynamic random access memory (eDRAM) towards high manufacturability at low cost, we explored the potential of integrating eDRAM in read channel integrated circuits (IC) to minimize the silicon area and energy consumption cost incurred by iterative signal detection and coding. As a result of the memory-intensive nature of iterative signal detection and coding algorithms, the silicon cost can be reduced in a straightforward manner by directly replacing conventional SRAM with eDRAM. However, reducing the energy consumption may not be trivial. In this paper, we present two techniques that trade eDRAM storage capacity to reduce the energy consumption of iterative signal detection and coding datapath. We have demonstrated dDRAM's energy saving potential by designing a representative iterative read channel at the 65 nm technology node. Simulation shows that we can eliminate over 99.99% of post-processing computation for dominant error events detection, and achieve up to a 67% reduction of decoding energy consumption.
Use of the Semipermeable Membrane Device (Spmd) to Sample Polycyclic Aromatic Hydrocarbon Pollution In A Lotic System (1996)

Abstract Relative concentrations of aqueous polycyclic aromatic hydrocarbons (PAH) were investigated in an urban creek. Samples were obtained at five sites within a 600-m segment of the creek that is critical habitat for an endangered species of fish. the sampling technique entailed immersion of semipermeable membrane devices (SPMDs) in the water for intervals as long as 64 d. SPMDs are passive, in situ, mtegrative samplers of bioavailable (truly dissolved) PAH and other hydrophobic organic contaminants. Two point sources of PAH to the 600-m segment of the creek were differentiated. Aqueous concentrations were found to wane dramatically over the relatively short section of the creek between the point sources. All samples were almost devoid of alkyl-substituted PAH, indicating that the ultimate sources were probably of pyrogenic nature. Key Words: bioconcentrationsemipermeable membrane deviceSPMDsamplingPAH
Plant-based Expression of SARS-CoV-2 antigens for use in an Oral Vaccine (2022)

While almost 300 vaccines against COVID-19 are presently in development, only a small minority (3%) explore the potential of oral vaccines (WHO). Oral vaccines produced in plants offer several advantages over traditional processes, including lower research and production costs, ease of scalability, and a negligible risk of contamination with human pathogens
Dynamics of the spatial electron density distribution of EUV-induced plasmas (2015)

We studied the temporal evolution of the electron density distribution in a low pressure pulsed plasma induced by high energy extreme ultraviolet (EUV) photons using microwave cavity resonance spectroscopy (MCRS). In principle, MCRS only provides space averaged information about the electron density. However, we demonstrate here the possibility to obtain spatial information by combining multiple resonant modes. It is shown that EUV-induced plasmas, albeit being a rather exotic plasma, can be explained by known plasma physical laws and processes. Two stages of plasma behaviour are observed: first the electron density distribution contracts, after which it expands. It is shown that the contraction is due to cooling of the electrons. The moment when the density distribution starts to expand is related to the inertia of the ions. After tens of microseconds, the electrons reached the wall of the cavity. The speed of this expansion is dependent on the gas pressure and can be divided into two regimes. It is shown that the acoustic dominated regime the expansion speed is independent of the gas pressure and that in the diffusion dominated regime the expansion depends reciprocal on the gas pressure.
An unusual cause of right lower abdominal pain in young female: A case report and review of literature (2016)

Renal infarction is a serious medical emergency but its diagnosis is often delayed because it mimics many other conditionsincluding renal stones, pyelonephritis, renal cancer and back pain. Early diagnosis as well as treatment is important for preventingrecurrence of infarction and irreversible kidney damage. The most common causes of renal infarction are heart diseases leadingto embolism, renal trauma and atheromatous disease. However, in some patients, the etiology remains unclear and is labeled asidiopathic renal infarction. We report an unusual case of right lower abdominal pain which was finally determined to idiopathicrenal infarction after extensive investigation.
Hydrodynamics of trickling flow in packed beds: Relative permeability concept (2002)

Abstract Liquid holdups and pressure drops for gas and liquid concurrent flow in packed beds were measured experimentally. To calculate the Ergun type constants, pressure drops were also measured for single‐ (gas)‐phase flow through the same packings. These measurements reveal that the Ergun type inertial constant depends on the particle shape. The beds were packed with porous and nonporous spheres, cylinders, extrudates, and Raschig rings. The experimental data were analyzed using the concept of relative permeabilities. The liquid‐phase relative permeability correlated well with the reduced liquid saturation in a unique power‐law form for all particles independent of their shape. The gas‐phase relative permeability as a function of the gas‐phase saturation followed the same law, but the exponent depends on the particle shape and gas‐phase Reynolds number. Predicted and experimental values for liquid holdups for all particle shapes agreed well with mean relative deviations less than 10%. Predictions of pressure drops for spherical particles, cylinders, and extrudates are at least as accurate as other less rigorous correlations (mean relative errors between 25 and 40%). Pressure drop predictions for Raschig rings are poorer (mean relative deviations of 90%), reflecting in part the variations in pressure drops from experiment to experiment with these particles.
Resection and Surgically Targeted Radiation Therapy for the Treatment of Larger Recurrent or Newly Diagnosed Brain Metastasis: Results From a Prospective Trial (2020)

Introduction Achieving durable local control (LC) for larger (e.g., >2-3 cm) brain metastasis whether newly diagnosed or recurrent remains problematic. Resection (R) alone is typically insufficient and adding radiation therapy (RT) still results in a 12-month recurrence rate of 20% or more in many series. Hypothesizing that R plus immediate radiation utilizing brachytherapy may improve outcomes for this cohort of patients, we designed and prospectively evaluated a permanently implanted surgically targeted radiation therapy (STaRT) device consisting of cesium-131 (Cs-131) seeds positioned within a collagen carrier (GammaTile, GT Medical Technologies, Tempe, AZ). The device was designed to prevent direct source-to-brain contact and maintain inter-source spacing after closure. Methods This was a subgroup analysis of a cohort of patients with either recurrent or previously untreated brain metastases enrolled in a prospective, multi-histology single-arm trial (ClinicalTrials.gov, NCT#03088579), conducted between February 2013 and February 2018, of resection and tumor bed brachytherapy with Cs-131 containing permanently implanted collagen tiles to deliver 60 Gray (Gy) at .5 cm depth. No additional local therapy was given without progression. Results A total of 16 metastases in 11 patients were treated; 12 tumors were recurrent and four were previously untreated. The median preoperative maximum diameter was 3.2 cm (range: 1.9-5.1 cm). Histology was seven breasts, six lungs, and three sarcomas. The median age was 60 years (range: 41-80 years); the Karnofsky Performance Status (KPS) was 70 (range: 70-90). The cohort consisted of seven females and four males. The mean time for implantation completion was five minutes. The median overall survival (OS) was 9.3 months. At a median radiographic follow-up of 9.5 months' treatment, site progression was found in 1/16 (6%) at 10.9 months, and the median treatment site time-to-progression (TTP) has not been reached [95% confidence interval (CI): >10.9 months]. At 12 months, the Kaplan-Meier (K-M) estimates for LC after R+STaRT for all tumors was 83%; for previously untreated tumors, LC at 12 months was 100% and for recurrent tumors, it was 80%. Two tumor beds (12.5%) experienced radiation brain changes: one had grade two and the other grade three. No surgical adverse events occurred. Conclusion In this single-arm precommercial study, R+STaRT demonstrated excellent safety and LC in this cohort. The device has recently received FDA clearance for use in newly diagnosed and recurrent brain metastasis, and randomized clinical trials vs. standard of care treatments in both settings are scheduled to open in 2020.
Photoelectron Imaging of Helium Droplets Doped with Xe and Kr Atoms (2008)

Helium droplets doped with Xe and Kr atoms were photoionized by using VUV synchrotron radiation from the Advanced Light Source and the resulting photoelectron images were measured. A wide range of He droplet sizes, photon energies, and dopant pick-up conditions was investigated. Significant ionization of dopants was observed at 21.6 eV, the absorption maximum of 2p (1)P1 electronic excited state of He droplets, indicating an indirect ionization mechanism via excitation transfer. The photoelectron images and spectra reveal multiple photoionization mechanisms and pathways for the photoelectrons to escape the droplet. Specifically, they show sets of sharp peaks assigned to two mechanisms for Penning ionization of the dopant by He* in which the photoelectrons leave the droplet with no detectable energy loss, a broad, intense feature representing electrons that undergo significant energy loss, and a small amount of ultraslow electrons that may result from electron trapping at the droplet surface. The droplet-size dependence of the broad, intense feature suggests the development of the conduction band edge in the largest droplets seen here ((N) approximately 250,000).
Principal Radiographic Characteristics for Cervical Spinal Deformity (2017)

4.
Adaptive Stabilization Of Electro-Dynamical Transducers (2014)

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 2014
Researches concerning the influence of the time periods between venom harvestings on quantitative and qualitative venom production in Vipera berus berus species. (2008)

Researches made on Vipera berus berus species show that it is obtained a lower qualitati ve and qualitative venom production from the animals at wh ich the venom-harvesting period is at two weeks. At the lots, which the venom-harvesting period is at three and four weeks, the qualitative and quantitative v enom production is significantly increased, this fact su ggesting that the quantitative venom production is restored in this time interval. The qualitative production evol ution shows that the dry substance from venom undergoes a gradual concentration process, which is easy contin ued after this period. The infection frequency of t he bucal cavity and venom glands increases in the same time with the number of the venom harvestings, the lower rate of the infections are recorded at the lot which the ve nom harvesting period is at one month. In the framework of the adder rearing and exploitat ion, an extremely important point is the venom harvesting technique. The venom quality like ware, but especially the animal's state of health is directly depending by the accura cy of this technique. The practical activity shows the frequent appearance of the open lesions ( bleedings) at the bucal cavity level, consequently to the venom harvesting process. Often , these lesions get infected, affecting both the venom quality and the functional integrity of the venomous system. Even in the case of a highly accuracy in the venom harvesting techni que, may frequently appear microlesions of the bucal cavity which can be infected. Because the adders are a poikiloterme species, their lesions are hardly healable. In this context, the e stablishing of the optimum venom harvesting perion is highly important for both obtaining an in creased quality of the venom ware and the health state of the animals. MATERIAL AND METHODS The experiences have followed to establish the infl uence of the time periods between the venom harvestings on the quality and quantity o f the venom production and the influence on the health state of the adders. The following of these parameters was made during an active season (7 months), from spring until autumn, respectively the period between two hibernation time periods. The researches took place in the framework of the Zoology discipline biobase, Faculty of Animal Breeding and Biotechnology, USAMV Cluj-Napoca. It were used six lots of 10 adult individuals each, fr om Vipera berus berus species. Three lots were contained female adders and three lots were co ntained male adders . It was followed the obtaining of an increased lots homogenity regarding the age and weight of the each
BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale (2019)

We report a safe and readily prepared reagent [1,1′-biphenyl]-4-yl 2-bromo-2,2-difluoroacetate (BBDFA) for Cu-catalyzed trifluoromethylation of allylic or benzylic alcohols. An operationally simple and column-chromatography-free process to prepare BBDFA was developed and demonstrated on >100 g scale. Detailed reaction calorimetry and thermal analysis of the deoxytrifluoromethylation were performed using cinnamyl alcohol as a model substrate, demonstrating that the reactions could be safely implemented on preparative scale.
Chemically Acylated tRNAs are Functional in Zebrafish Embryos (2023)

Genetic code expansion has pushed protein chemistry past the canonical 22 amino acids. The key enzymes that make this possible are engineered aminoacyl tRNA synthetases. However, as the number of genetically encoded amino acids has increased over the years, obvious limits in the type and size of novel side chains that can be accommodated by the synthetase enzyme become apparent. Here, we show that chemically acylating tRNAs allow for robust, site-specific incorporation of unnatural amino acids into proteins in zebrafish embryos, an important model organism for human health and development. We apply this approach to incorporate a unique photocaged histidine analogue for which synthetase engineering efforts have failed. Additionally, we demonstrate optical control over different enzymes in live embryos by installing photocaged histidine into their active sites.
ChemInform Abstract: STEREOSELECTIVE ALDOL CONDENSATION. USE OF CHIRAL BORON ENOLATES (1981)

Abstract Ausgangssubstanzen für die Darstellung der bei der stereoselektiven Aldolkondensation verwendeten Bor‐enolate (V) und (VI) sind optisch rein käufliche (S)‐ (I) und (R)‐Mandelsäure (II), die durch katalytische Hydrierung, Kondensation mit Ethyl‐ Ii zu den entsprechenden Ethylketonen (Ausb. 75%) und Silylierung in die chiralen Ketone (III) und (IV) übergeführt werden.
Demonstration of DNA binding factors interacting with a fragment of the canine prostate arginine esterase gene promoter (1992)

We have studied, by the gel mobility shift assay, the interaction of DNA binding proteins with a fragment of the proximal promoter (from nucleotides -177 to -47) of the androgen-regulated canine prostate arginine esterase gene. Several shifted bands were obtained using nuclear extracts from various tissues. In the case of the prostate, the intensity of some of the shifted bands was decreased or increased when the extracts were prepared from animals that had been castrated 12 days earlier. Several of the DNA-protein complexes could be assigned to an interaction with part or all of the sequence GGGGGTGGGGG from-124 to -114. We also obtained evidence for the presence of protein(s) interacting with an Sp1 motif present in the same fragment. These results suggest that some ubiquitous factors different from the androgen receptors could be involved in the regulation of the arginine esterase gene.