gebhart/patrepeval huggingface dataset:
Fused Bicyclic Gly-Asp β-Turn Mimics with Specific Affinity for GPIIb-IIIa (1999)

Disubstituted isoquinolones 2 and 3 have affinity for GPIIb-IIIa and represent leads for further structural evaluation. Structure-activity studies centered on the bicyclic beta-turn mimic contained in these molecules indicated that this moiety could accommodate a variety of modifications. Specifically, monocyclic, 6, 5-bicyclic, and 6,7-bicyclic structures provide compounds with affinity for GPIIb-IIIa. Within the 6,6-series, isoquinoline, tetralin, tetralone, and benzopyran nuclei yield potent antagonists that are specific for GPIIb-IIIa. Attachment of the arginine isostere (benzamidine) to the supporting nucleus can be accomplished with an ether or amide linkage, although the latter enhances activity. Several compounds in this series provided measurable blood levels after oral dosing. Conversion of the acid moiety in these molecules to an ester generally provided compounds which gave greater systemic exposure after oral administration. Absolute bioavailabilities in the rat for the ethyl ester prodrug derivatives of the tetralin, tetralone, and benzopyran analogues of 3 were 28%, 23%, and 24%, respectively.
Deep learning for assessing the aesthetics of professional photographs (2022)

Abstract Aesthetic quality assessment for photographs is an important research topic since it can be used for a number of applications, such as image database management or image browsing. In 2012, the aesthetic visual analysis (AVA) dataset has been proposed. It has since then been used to train the majority of computational models of aesthetics assessment. We observe that AVA is mainly composed of competitive photographs which notion of aesthetics differs from other kinds of photographs, such as professional photographs. In this paper, we evaluate whether or not recent aesthetics assessment models generalize well and perform well over professional photographs. We noticed that the different models we tested behave differently on both categories, and therefore do not generalize well. Besides, we fine‐tuned one of the tested model using professional photographs and the results show that this fine‐tuning is effectively improving the coverage of the methods.
Chronic wounds: Treatment consensus (2022)

The Wound Healing Foundation (WHF) recognised a need for an unbiased consensus on the best treatment of chronic wounds. A panel of 13 experts were invited to a virtual meeting which took place on 27 March 2021. The proceedings were organised in the sub-sections diagnosis, debridement, infection control, dressings, grafting, pain management, oxygen treatment, outcomes and future needs. Eighty percent or better concurrence among the panellists was considered a consensus. A large number of critical questions were discussed and agreed upon. Important takeaways included that wound care needs to be simplified to a point that it can be delivered by the patient or the patient's family. Another one was that telemonitoring, which has proved very useful during the COVID-19 pandemic, can help reduce the frequency of interventions by a visiting nurse or a wound care center. Defining patient expectations is critical to designing a successful treatment. Patient outcomes might include wound specific outcomes such as time to heal, wound size reduction, as well as improvement in quality of life. For those patients with expectations of healing, an aggressive approach to achieve that goal is recommended. When healing is not an expectation, such as in patients receiving palliative wound care, outcomes might include pain reduction, exudate management, odour management and/or other quality of life benefits to wound care.
Embedding Applications within a Storage Appliance (2005)

Storage densities for magnetic media have improved over the last decade at a rate that exceeds that of Moore’s Law. The pace of this technological advance has resulted in dramatic cost decreases for hard disk storage systems, and
Modeling and Parameter Identification of Lithium-Ion Capacitor Modules (2014)

Lithium-ion capacitors (LiCs) are novel storage devices with a high power density and high energy density compared to conventional supercapacitors (SCs). This paper proposes a method to validate the previously developed characterization and modeling methods, which are the same as those used for a conventional SC with double-layer-activated carbon technology. This paper presents two relevant contributions. First, a full frequency range model and the experimental parameter identification of two kinds of LiC cells are presented. In order to extend the LiC cell parameter identification to a module composed of several series-connected cells, an aggregate model of the LiC module was investigated and validated. The results of experiments and numerical simulations demonstrate the value and effectiveness of the proposed model when the cells operate at room temperature.
The ARMC5 gene shows extensive genetic variance in primary macronodular adrenocortical hyperplasia (2015)

This is the most genetic variance of the ARMC5 gene ever described in a single patient with PMAH: each of 16 adrenocortical nodules had a second new, 'private,' and--in most cases--completely inactivating ARMC5 defect, in addition to the germline mutation. The data support the notion that ARMC5 is a TSG that needs a second, somatic hit, to mediate tumorigenesis leading to polyclonal nodularity; however, the driver of this extensive genetic variance of the second ARMC5 allele in adrenocortical tissue in the context of a germline defect and PMAH remains a mystery.
Cystometric Changes in Pressure-guided Acute Distension Rat Model of the Underactive Bladder(superscript TM) (2009)

Objective: Acute bladder distension results in pressure ischemia, subsequent reperfusion injury, and ultimately damage to the detrusor. We hypothesize that changes in pressure may be a key factor to damage resulting from over-distension and developed a pressure-guided distension model to evaluate cystometric changes. Materials and Methods: Three groups of adult female Sprague Dawley rats (250 g) were used: a sham distended control group, a 3-day (3D) and 7-day (7D) follow-up group after pressure-guided distension. Under pentobarbital anesthesia, the urethra was clamped and saline was infused (0.04 mL/min) under continuous intravesical pressure monitoring. After reaching 120 cm H2O pressure, infusion was stopped and clamping was maintained for 30 minutes. For sham distension, all procedures except the saline infusion were done. Results: There were no bladder ruptures during distension. Distension volumes needed to achieve the fixed pressure were variable (1.68-2.90 mL), but mean distension volumes were similar between the 3D and 7D groups (2.1±0.1 mL vs. 2.2±0.3 mL). After distension, maximal cystometric capacity and residual urine volume were increased at both time points. Voiding efficiencies were decreased significantly in both the 3D and 7D groups (p＜0.05) compared to controls. Maximal vesical pressure and bladder compliance showed no change before and after distension. Conclusion: Our pressure-guided distension model exhibits cystometric characteristics of bladder decompensation. This model for the underactive bladder (superscript TM) (UAB) may prove useful to further the development of targeted UAB (superscript TM) treatments.
Emission spectrum of a dressed exciton-biexciton complex in a semiconductor quantum dot (2008)

The photoluminescence spectrum of a single quantum dot was recorded as a secondary resonant laser optically dressed either the vacuum-to-exciton or the exciton-to-biexciton transitions. High-resolution polarization-resolved measurements using a scanning Fabry-Perot interferometer reveal splittings of the linearly-polarized fine-structure states that are non-degenerate in an asymmetric quantum dot. These splittings manifest as either triplets or doublets and depend sensitively on laser intensity and detuning. Our approach realizes complete resonant control of a multi-excitonic system in emission, which can be either pulsed or continuous-wave, and offers direct access to the emitted photons.
Book reviews (1994)

Sander L. Gilman, FREUD, RACE AND GENDER, Princeton, NJ: Princeton University Press, 1993, xv + 277 pp., £19.95. Akbar S. Ahmed, POSTMODERNISM AND ISLAM: PREDICAMENT AND PROMISE, London: Routledge, 1992, x + 294 pp., £35.00 hb, £10.99 pb. Tariq Modood, NOT EASY BEING BRITISH: COLOUR, CULTURE AND CITIZENSHIP, London: Runnymede Trust and Trentham Books, 1992, 93 pp. £7.95. Yen Le Espiritu, ASIAN AMERICAN PANETHNICITY: BRIDGING INSTITUTIONS AND IDENTITIES, Philadelphia: Temple University Press, 1992, 222 pp., $34.95. Mitchell Duneier, SUM'S TABLE: RACE, RESPECTABILITY AND MASCULINITY, Chicago, IL: University of Chicago Press, 1992, 192 pp., $19.95. Steve Bruce, THE RED HAND: PROTESTANT PARAMILITARIES IN NORTHERN IRELAND, Oxford: Oxford University Press, 1992, xiv + 311 pp., £7.99. Nita Kumar, FRIENDS, BROTHERS AND INFORMANTS: FIELDWORK MEMOIRS OF BANARAS, Berkeley, CA: University of California Press, 1992, 260 pp., $35.00 cloth, $13.00 pb. Joshua A. Fishman, REVERSING LANGUAGE SHIFT: THEORETICAL AND EMPIRICAL FOUNDATIONS OF ASSISTANCE TO THREATENED LANGUAGES, Clevedon, Avon, England: Multilingual Matters, 1991, xiii + 431 pp., £43.00. Debbie Epstein, CHANGING CLASSROOM CULTURES: ANTI‐RACISM, POLITICS AND SCHOOLS, Stoke‐on‐Trent: Trentham Books, 1993, viii + 168 pp., f 10.95. Beverley Naidoo, THROUGH WHOSE EYES? EXPLORING RACISM: READER, TEXT AND CONTEXT, Stoke‐on‐Trent: Trentham Books, 1992, 160 pp., £10.95. F. Anthias and N. Yuval‐Davis (in association with H. Cain) RACIALIZED BOUNDARIES: RACE, NATION, GENDER, COLOUR AND CLASS AND THE ANTI‐RACIST STRUGGLE, London: Routledge, hb. £40. A. Ward, J. Gregory, and N. Yuval‐Davis, WOMEN AND CITIZENSHIP IN EUROPE: BORDERS, RIGHTS AND DUTIES, Trentham Books & EFSF, £11.95, pb. David L. Dudley, MY FATHER'S SHADOW: INTERGENERATIONAL CONFLICT IN AFRICAN AMERICAN MEN'S AUTOBIOGRAPHY, Philadelphia, PA: University of Pennsylvania Press, 1991, 218 pp., $23.70. John E. Zucchi, THE LITTLE SLAVES OF THE HARP. ITALIAN CHILD STREET MUSICIANS IN NINETEENTH‐CENTURY PARIS, LONDON AND NEW YORK, Montreal & Kingston: McGill‐Queen's University Press, 1992, XV + 208 pp., £25.95. Helen Buckley, FROM WOODEN PLOUGHS TO WELFARE: WHY INDIAN POLICY FAILED IN THE PRAIRIE PROVINCES, Montreal: McGill‐Queen's University Press, 1992, 209 pp., Can. $34.96.
A phase 1, open-label, dose escalation study of enoblituzumab (MGA271) in pediatric patients with B7-H3-expressing relapsed or refractory solid tumors. (2017)

TPS2596 Background: Enoblituzumab, is an Fc optimized humanized IgG1 monoclonal antibody that binds to B7-H3 (CD276), a member of the B7 family. It is Fc-engineered to enhance effector function including antibody dependent cellular cytotoxicity (ADCC). IHC analyses with the parental anti-B7H3 mAb specificity incorporated in enoblituzmab revealed limited B7-H3 expression in normal tissues but high expression in many cancers (Loo et al., 2012). Among pediatric solid tumors, high expression of B7-H3 has been reported in neuroblastoma, rhabdomyosarcoma, osteosarcoma, Wilms tumor, Ewing’s sarcoma and desmoplastic small round cell tumor. B7-H3 overexpression correlates with poor prognosis in a broad range of cancers in adults suggesting a potential role in enabling tumor immune escape. ADCC and potential modulation of T cell function resulting in enhanced antitumor immune response are presumed mechanisms of action of enoblituzumab. Methods: This is an open-label, dose escalation / cohort expansion phase 1 study (NCT02982941) designed to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of enoblituzumab in children and young adults with B7-H3-expressing relapsed or refractory malignant solid tumors. A 3+3 design is used in escalating dose cohorts of weekly intravenous (IV) enoblituzumab starting at 10 mg/kg. Response is first determined at 8 weeks. irRECIST is used for response assessment for patient management. Enoblituzumab may continue up to 2 years based on response. Cohort expansion phase, to further define the safety and initial antitumor activity of enoblituzumab, will start after maximum tolerated dose is determined. The patients are assigned to 1 of 5 cohorts based on disease type as follows: 1) neuroblastoma - measurable disease, 2) neuroblastoma - non-measurable disease, 3) rhabdomyosarcoma, 4) osteosarcoma, and 5) Ewing’s sarcoma, Wilms’ tumor and desmoplastic small round cell tumors. Enrollment is ongoing. Ref : Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Loo D, Alderson RF, Chen FZ, Huang L et al. Clin Cancer Res. 2012; 18:3834-45. Clinical trial information: NCT02982941.
Isolation of an Atypical Strain ofActinobacillus pleuropneumoniaeSerotype 1 with a Truncated Lipopolysaccharide Outer Core and No O-Antigen (2005)

A field isolate of Actinobacillus pleuropneumoniae, the causative agent of porcine fibrinohemorrhagic necrotizing pleuropneumonia, was sent to the diagnostic laboratory for serotyping. The isolate presented a clear reaction, with both polyclonal antibodies against serotype 1 and monoclonal antibodies against the capsular polysaccharide of serotype 1. It also exhibited a PCR profile of Apx toxins expected for serotype 1. The isolate, however, failed to react with monoclonal antibodies against the O-antigen of serotype 1 lipopolysaccharide (LPS), suggesting a rough phenotype. The lipid A-core region of the isolate migrated faster than the corresponding region of the serotype 1 reference strain S4074 by Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis, suggesting the presence of a truncated core. Sugar analysis and mass spectrometry analysis of the O-deacylated LPS from the field isolate were consistent with the absence of O-antigen and truncation of the outer core compared to the wild-type reference strain. Experimental infection of pigs confirmed the virulence of the isolate. This is the first report of an isolate of A. pleuropneumoniae serotype 1 with a truncated outer core and a rough LPS phenotype. Veterinary diagnostic laboratories should be vigilant, since infections caused by such an isolate will not be detected by serological tests based on LPS O-antigen.
HBM tester parasitic effects on high pin count devices with multiple power and ground pins (2006)

A new Human Body Model (HBM) SPICE equivalent lumped element model (LEM) circuit that reproduces parasitic resistance, capacitance and inductance (RLC) tester effects has been used to investigate how the HBM current flows through several different relay-matrix HBM simulators. SPICE analysis shows that unwanted interaction between the simulators RLC parasitics and the IC component could be significantly reduced, if all of the HBM current flowed through the primary ground path and not through parasitic current paths unintentionally built inside the HBM simulators.
IFN and cytokine responses in ducks to genetically similar H5N1 influenza A viruses of varying pathogenicity (2018)

Ducks, the reservoir host, are generally permissive to influenza A virus infection without disease symptoms. This natural ecology was upset by the emergence of H5N1 strains, which can kill ducks. To better understand host-virus interactions in the reservoir host, and influenza strain-specific molecular contributions to virulence, we infected White Pekin ducks with three similar H5N1 viruses, with known differences in pathogenicity and replication rate. We quantified viral replication and innate immune gene activation by qPCR, in lung and spleen tissues, isolated on each of the first 3 days of infection. The three viruses replicated well, as measured by accumulation of matrix gene transcript, and viral load declined over time in the spleen. The ducks produced rapid, but temporally limited, IFN and cytokine responses, peaking on the first day post-infection. IFN and proinflammatory cytokine gene induction were greater in response to infection with the more lethal viruses, compared to an attenuated strain. We conclude that a well-regulated IFN response, with the ability to overcome early viral immune inhibition, without hyperinflammation, contributes to the ability of ducks to survive H5N1 influenza replication in their airways, and yet clear systemic infection and limit disease.
Luminescence of the Nonclassical Homoleptic Metal Carbonyl Complex [Rh(CO)4]+ (2002)

The nonclassical [Rh(CO)(4)](+) cation is luminescent at low temperature with a peak maximum at 19640 cm(-1) and a full-width at half-maximum of 2900 cm(-1). Both the solution absorption and low-temperature solid-state luminescence spectra of the [Rh(CO)(4)](1-Et-CB(11)F(11)) salt are reported. The cesium salt of the [1-Et-CB(11)F(11)](-) counterion is also luminescent (with a peak maximum at 22650 cm(-1)), but the emission maximum of [Rh(CO)(4)](+) is lower in energy. The Rh-C bond length changes of approximately 0.07 A in the excited state are calculated. The calculated bond length changes in the nonclassical [Rh(CO)(4)](+) ion are not very different from those in classical complexes.
Integrated modeling and analysis of computer-based embedded control systems (2004)

Embedded real-time systems are ubiquitous in modern society, many of which perform safety-critical functions, and therefore, it is imperative to have tools and techniques that can guarantee a high degree of system correctness. They typically perform information processing on a digital computer tightly coupled with the continuous physical environment. Even though hybrid systems is an active research area, most work has ignored the scheduling behavior of software processes due to contention for the shared CPU resource. We propose an integrated approach based on hybrid automata and model-checking for modeling and analysis of computer-based embedded control systems where real-time scheduling behavior of the controller software is explicitly represented at the model-level, together with the physical environment that it interacts with. An application example is used to demonstrate the benefits of the integrated approach in performing tradeoff analysis involving both the controller software and the controlled physical system.
Heterointerface Engineering of Broken-Gap InAs/GaSb Multilayer Structures (2015)

Broken-gap InAs/GaSb strain balanced multilayer structures were grown by molecular beam epitaxy (MBE), and their structural, morphological, and band alignment properties were analyzed. Precise shutter sequence during the MBE growth process, enable to achieve the strain balanced structure. Cross-sectional transmission electron microscopy exhibited sharp heterointerfaces, and the lattice line extended from the top GaSb layer to the bottom InAs layer. X-ray analysis further confirmed a strain balanced InAs/GaSb multilayer structure. A smooth surface morphology with surface roughness of ∼0.5 nm was demonstrated. The effective barrier height -0.15 eV at the GaSb/InAs heterointerface was determined by X-ray photoelectron spectroscopy, and it was further corroborated by simulation. These results are important to demonstrate desirable characteristics of mixed As/Sb material systems for high-performance and low-power tunnel field-effect transistor applications.
Spatial biomarker of disease and detection of spatial organization of cellular receptors (2023)

A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.
Ab Initio Molecular Orbital Study of Substituent Effects in Vaska Type Complexes (trans-IrL2(CO)X): Electron Affinities, Ionization Potentials, Carbonyl Stretch Frequencies and the Thermodynamics of H2 Dissociative Addition (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb Initio Molecular Orbital Study of Substituent Effects in Vaska Type Complexes (trans-IrL2(CO)X): Electron Affinities, Ionization Potentials, Carbonyl Stretch Frequencies and the Thermodynamics of H2 Dissociative AdditionFaraj Abu-Hasanayn, Alan S. Goldman, and Karsten Krogh-JespersenCite this: Inorg. Chem. 1994, 33, 22, 5122–5130Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ic00100a043https://doi.org/10.1021/ic00100a043research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma (2010)

Deletion of chromosome 9p in ccRCC occurred in 14% of patients and was associated with higher grade and T classification, and the presence of lymph node and distant metastases. In addition, 9p deletion independently conferred a worse prognosis for patients with localized ccRCC, and most noteworthy, in patients with localized, small renal masses. Preoperatively identifying patients with 9p deletions will improve risk stratification and will help to select appropriate patients for surveillance protocols or aggressive treatment.
Novel Percolation Mechanism in PMMA Matrix Composites Containing Segregated ITO Nanowire Networks (2007)

Abstract Poly(methyl methacrylate) (PMMA)/indium tin oxide (ITO) nanocomposites were prepared by mechanical mixing and compression molding in order to study the properties and microstructure of the composites. The composites were examined by optical and scanning electron microscopy, impedance spectroscopy, and UV‐VIS spectrophotometry. It was observed that upon compaction of the powders above the glass‐transition temperature of the matrix, the PMMA transforms from spherical to polyhedral‐shaped, and develops sharp edges and flat faces. The ITO nanoparticles do not penetrate the polymer particles, resulting in a novel segregated network microstructure. Excellent correlation between the electrical, optical, and microscopy data also provide good insight about the behavior of the filler as the content is increased in the nanocomposites. There is strong evidence that the ITO nanoparticles are extensively displaced during compaction as the PMMA powders become polyhedral‐shaped. Our results indicate that percolation occurs due to the ITO forming a continuous network along the edges of the faceted PMMA particles. The ITO nanoparticles do not appear on the faces of the PMMA particles until after a percolation path has formed and a marked increase in electrical conductivity has occurred. This behavior significantly diverges from previous models for segregated network microstructures which proposed that percolation occurred as the result of limited displacement of the filler during compaction of the mixed powders.