gebhart/patrepeval huggingface dataset:
Rate Constants for 1,2-Hydrogen Migration in Cyclohexylidene and in Substituted Cyclohexylidenes1 (1999)

Laser flash photolysis (UV-LFP, 308 nm) of suitably substituted oxadiazolines leads to cyclohexylidene (14a), 4-tert-butyl-cyclohexylidene (14b), 2-trifluoromethylcyclohexylidene (14d), 8-aza-8-methyl[3.2.1]oct-3-ylidene (14e), diethylcarbene (14f), and ethyl(methyl)carbene (14h). Carbene intermediates were inferred from the products of steady state photolyses, and their pyridinium ylides were inferred from transient absorption spectra observed when pyridine was present. Yields of the pyridinium ylides 15a−h as a function of pyridine concentration gave the lifetimes (τ) for carbenes 14a−h in cyclohexane, cyclohexane-d12, and benzene solutions, at 22 °C. The intermediacy of cyclohexylidene (14a) was inferred from the observation of cyclohexene formed in both the LFP and steady state (SS) experiments. The major products from dual wavelength irradiation of the oxadiazolines (at 254 and 300 nm) were those of 1,2-migration of hydrogen (1,2-H) in the corresponding carbenes. 2-Trifluoromethylcyclohexylidene gave 3-trifluoromethylcyclohexene and 1-trifluoromethylcyclohexene in a 9.8:1 ratio. The kinetic data support the conclusion that 1,2-H in the cyclohexylidenes is accelerated, relative to 1,2-H in dimethylcarbene. A 4-tert-butyl substituent has a negligible effect on the rate constant for 1,2-H, but the CF3 group at the α-position decelerates 1,2-H by roughly 10-fold, as inferred from the distribution of products.
Highly Stable, Solution‐Processed Ga‐Doped IZTO Thin Film Transistor by Ar/O2 Plasma Treatment (2019)

Abstract The effects of gallium doping into indium–zinc–tin oxide (IZTO) thin film transistors (TFTs) and Ar/O 2 plasma treatment on the performance of a‐IZTO TFT are reported. The Ga doping ratio is varied from 0 to 20%, and it is found that 10% gallium doping in a‐IZTO TFT results in a saturation mobility ( µs at ) of 11.80 cm 2 V −1 s −1 , a threshold voltage ( V th ) of 0.17 V, subthreshold swing (SS) of 94 mV dec −1 , and on/off current ratio ( I on / I off ) of 1.21 × 10 7 . Additionally, the performance of 10% Ga‐doped IZTO TFT can be further improved by Ar/O 2 plasma treatment. It is found that 30 s plasma treatment gives the best TFT performances such as µs at of 30.60 cm 2 V −1 s −1 , V th of 0.12 V, SS of 92 mV dec −1 , and I on / I off ratio of 7.90 × 10 7 . The bias‐stability of 10% Ga‐doped IZTO TFT is also improved by 30 s plasma treatment. The enhancement of the TFT performance appears to be due to the reduction in the oxygen vacancy and OH concentrations.
The longitudinal impact of probiotic and peanut oral immunotherapy on health‐related quality of life (2017)

Probiotic and peanut oral immunotherapy has a sustained beneficial effect on psychosocial impact of food allergy at 3 and 12 months after end-of-treatment. Treatment was not associated with reduced HRQL relative to baseline in either PPOIT or placebo groups, indicating that PPOIT was well tolerated and psychological well-being was not negatively impacted. Improved HRQL was specifically associated with acquisition of sustained unresponsiveness.
Catalyst design from theory to practice: general discussion (2016)

Hans-Joachim Freund opened the discussion of the paper by Alberto Roldan: How is the atomic hydrogen produced on the greigite surface? In the paper (DOI: 10.1039/C5FD00186B) there is no comment whether you studied dissociate hydrogen adsorption. Alberto Roldan answered: We agree
Admittance selection for force-guided assembly of polyhedral parts in single-point contact (2004)

The selection of the proper admittance is important in achieving force-guided assembly. This paper identifies procedures for selecting the appropriate spatial admittance to achieve reliable force-guided assembly of polyhedral parts for single-point frictionless contact cases. Sets of conditions that are imposed on the admittance matrix for different types of single-point contact are presented. These conditions ensure that the motion that results from contact reduces part misalignment in the selected contact state. We show that, for bounded misalignments, if an admittance satisfies the misalignment-reduction conditions at a finite number of contact configurations, then the admittance also satisfy the conditions at all intermediate configurations.
Prozessanalyse hybrider Trennverfahren am Beispiel der Kopplung von Rektifikation und Membrantrennung (2005)

Abstract Um der Forderung nach immer wirtschaftlicheren und umweltschonenderen Produktionsverfahren in der chemischen Industrie nachzukommen, sind hybride Trennverfahren derzeit verstärkt im Fokus wissenschaftlicher und industrieller Forschung. Insbesondere die Kombination von thermischer Trenntechnik und innovativen Verfahren schafft starke Synergien. Deren Potenzial wird im industriellen Maßstab zurzeit kaum ausgeschöpft, da eine sichere Prozessanalyse aufgrund der Komplexität nur in begrenztem Umfang möglich ist. Während bisher für Auslegung und Optimierung ausschließlich Short‐Cut‐ und Gleichgewichtsmodelle eingesetzt werden, wird in diesem Beitrag für die Prozessanalyse ausschließlich auf Stoffaustauschmodelle zurückgegriffen. Die Anwendbarkeit wird anhand der Trennung eines ternären Gemisches mittels Rektifikation/Pervaporation gezeigt. Der Einfluss relevanter Struktur‐ und Betriebsparameter auf die erforderliche Membranfläche und Kosten wird untersucht. Abschließend zeigt ein Verfahrensvergleich die Stärken und Schwächen des Hybridprozesses auf.
REEF (2013)

In this demo proposal, we describe REEF, a framework that makes it easy to implement scalable, fault-tolerant runtime environments for a range of computational models. We will demonstrate diverse workloads, including extract-transform-load MapReduce jobs, iterative machine learning algorithms, and ad-hoc declarative query processing. At its core, REEF builds atop YARN (Apache Hadoop 2's resource manager) to provide retainable hardware resources with lifetimes that are decoupled from those of computational tasks. This allows us to build persistent (cross-job) caches and cluster-wide services, but, more importantly, supports high-performance iterative graph processing and machine learning algorithms. Unlike existing systems, REEF aims for composability of jobs across computational models, providing significant performance and usability gains, even with legacy code. REEF includes a library of interoperable data management primitives optimized for communication and data movement (which are distinct from storage locality). The library also allows REEF applications to access external services, such as user-facing relational databases. We were careful to decouple lower levels of REEF from the data models and semantics of systems built atop it. The result was two new standalone systems: Tang, a configuration manager and dependency injector, and Wake, a state-of-the-art event-driven programming and data movement framework. Both are language independent, allowing REEF to bridge the JVM and .NET.
ChemInform Abstract: 1,9‐Alkano‐Bridged 2,3,4,5‐Tetrahydro‐1H‐3‐benzazepines with Affinity for the α2‐Adrenoceptor and the 5‐HT1A Receptor. (1990)

Abstract The bicyclic acids (I) are coupled with the ethanolamine (II) and subsequently reduced to form the amines (III) which undergo ring closure upon consecutive heating with PCl 5 and AlCl 3 to give the benzazepines (IV).
Psychophysical investigations of the temporal modulation sensitivity function in amblyopia: spatiotemporal interactions. (1982)

Temporal modulation sensitivity functions were measured in response to counterphase sine-wave gratings of various spatial frequencies in seven strabismic and/or anisometropic amblyopes and in two stimulus-deprivation amblyopes. Both movement/flicker and pattern detection thresholds were determined. Strabismic and/or anisometropic amblyopes showed reduced sensitivity for movement/flicker and pattern detection in the amblyopic eyes, which were dependent on both the spatial and temporal frequencies of the stimulus and the detection criterion. At medium and high spatial frequencies, substantial reductions in movement/flicker detection were present, which were generally more marked for low temporal modulation frequencies. Reductions in pattern sensitivity were greater at the higher spatial frequencies, although some amblyopes showed losses in sensitivity at low spatial frequencies as well. The losses observed in the spatiotemporal transfer function of the amblyopic eyes were greater than those found with unstructured stimuli (uniform field flicker) and were not eliminated under reduced luminance. In subjects with amblyopia caused by stimulus deprivation, losses in spatiotemporal contrast sensitivity were either invariant across temporal frequencies or increased at higher rates of temporal modulations.
Entre desserrement et resserrement du verrou de l’État (2020)

Resume Cet article explore les transformations du modele d’administration territoriale francais et les processus de migration de l’autorite depuis le milieu des annees 1970 a partir des mobilisations de deux grandes categories d’acteurs : les elus locaux, leurs associations et leurs relais institutionnels au Senat, d’une part ; les hauts fonctionnaires des administrations centrales, et particulierement ceux du ministere du Budget, d’autre part. Il cherche a identifier les contextes et mecanismes qui ont permis la conversion d’asymetries ponctuelles de pouvoir en asymetries plus durables, qui ont modifie les trajectoires de reforme. Il met en evidence une dynamique de desserrement du verrou de l’Etat, qui court depuis le milieu des annees 1970 jusqu’au milieu des annees 1990, et connait son apogee avec le vote des lois de decentralisation. Il montre a contrario pourquoi l’adoption de l’euro s’est traduite par un recul tres net de l’autonomie budgetaire et fiscale des collectivites et par l’adoption de politiques de fusions de collectivites, et comment la crise des dettes souveraines a amplifie ce resserrement du verrou de l’Etat.
831 Serum Biomarkers Are Associated With Endoscopic and Clinical Outcomes in Crohn’s Disease Patients Receiving Vedolizumab Therapy (2019)

INTRODUCTION: Vedolizumab is a selective monoclonal antibody directed against a4b7 integrin on lymphocytes and is safe and effective for the induction and maintenance of remission in Crohn’s disease. Serum biomarkers are needed to help guide therapy and predict patient outcomes. This study evaluated biomarker concentrations and patient outcomes during vedolizumab treatment. METHODS: Serum was collected from patients with Crohn’s disease receiving vedolizumab infusions at weeks 0, 2, 6, 14 and ≥26. Biomarkers including soluble(s)-a4b7, s-vascular cell adhesion molecule (VCAM)-1, s-intracellular adhesion molecule (ICAM)-1, and s-mucosal addressin cell adhesion molecule (MAdCAM)-1 were measured and evaluated as surrogate markers associated with clinical and endoscopic outcomes. Statistical analysis was performed using the Mann-Whitney U test for continuous data. RESULTS: Twenty-two patients with Crohn’s disease were included (Table 1). In all patients, s-MAdCAM significantly decreased over time as compared to baseline, and s-a4b7 increased compared to baseline (Figure 1). Overall, s-ICAM1 and s-VCAM1 did not change significantly over time in the entire cohort, however, differentially changed in patients with remission. At week 2, median concentrations of s-ICAM1 were higher in patients with compared to those without clinical remission: 675.1 ng/mL vs. 270.1 ng/mL, respectively ( P = 0.046). At week 6, median s-ICAM1 concentrations were higher in patients with compared to without endoscopic remission: 545.7 ng/mL vs. 286.2 ng/mL, respectively ( P = 0.027) and clinical remission: 669.1 ng/mL vs. 291 ng/mL, respectively ( P = 0.034). At week 6, median s-VCAM1 concentrations were higher in patients with compared to without endoscopic remission: 859.6 vs. 460.31, respectively ( P = 0.027) and numerically higher in patients with clinical remission: 859.6 ng/mL vs. 460.6 ng/mL, respectively ( P = 0.1). At week 26, there was no difference in median s-VCAM1 or s-ICAM1 concentrations between remitters vs. non-remitters (Table 2). CONCLUSION: Higher concentrations of s-ICAM-1 and s-VCAM-1 early in treatment with vedolizumab may be predictive of subsequent remission in patients with Crohn’s disease. During maintenance, there was no association between serum biomarkers and endoscopic or clinical outcomes. These findings may help predict early patient response to treatment with vedolizumab in Crohn’s disease but will require further validation.
Activation of β‐catenin signalling by GSK‐3 inhibition increases p‐glycoprotein expression in brain endothelial cells (2008)

This study investigates involvement of beta-catenin signalling in regulation of p-glycoprotein (p-gp) expression in endothelial cells derived from brain vasculature. Pharmacological interventions that enhance or that block beta-catenin signalling were applied to primary rat brain endothelial cells and to immortalized human brain endothelial cells, hCMEC/D3, nuclear translocation of beta-catenin being determined by immunocytochemistry and by western blot analysis to confirm effectiveness of the manipulations. Using the specific glycogen synthase kinase-3 (GSK-3) inhibitor 6-bromoindirubin-3'-oxime enhanced beta-catenin and increased p-gp expression including activating the MDR1 promoter. These increases were accompanied by increases in p-gp-mediated efflux capability as observed from alterations in intracellular fluorescent calcein accumulation detected by flow cytometry. Similar increases in p-gp expression were noted with other GSK-3 inhibitors, i.e. 1-azakenpaullone or LiCl. Application of Wnt agonist [2-amino-4-(3,4-(methylenedioxy) benzylamino)-6-(3-methoxyphenyl)pyrimidine] also enhanced beta-catenin and increased transcript and protein levels of p-gp. By contrast, down-regulating the pathway using Dickkopf-1 or quercetin decreased p-gp expression. Similar changes were observed with multidrug resistance protein 4 and breast cancer resistance protein, both known to be present at the blood-brain barrier. These results suggest that regulation of p-gp and other multidrug efflux transporters in brain vasculature can be influenced by beta-catenin signalling.
Performance and modeling of WCDMA/HSDPA transmission/H-ARQ schemes (2003)

As part of 3GPP Release'5 standardization work on WCDMA/UTRA, a new packet concept has been added to grant high speed downlink packet access (HSDPA). One of the central features of the HSDPA concept is advanced physical layer retransmission scheduling employing soft combining gain, incremental redundancy, and low retransmission delays. Since the average retransmission probability in HSDPA is typically on the order of 10-40%, the retransmission scheduling needs to be accurately simulated and modeled at both link and network level. Based on an extensive simulation campaign, this paper presents methods to map the link level performance of the HSDPA retransmission schemes into a low-complexity representation suitable for network level evaluation. The method accurately predicts the throughput and delay performance within a few percent.
Molecular recognition-controlled membrane disruption by a bis(crown ether) bola-amphiphile (1996)

T. M. Fyles and B. Zeng, Chem. Commun., 1996, 2295 DOI: 10.1039/CC9960002295
Dual-Mode Power Amplifier Module with In-Band Reconfigurable Output Power for Multifunctional Radar and Radio Communication Systems (2014)

International audience
Faculty Opinions recommendation of Prodrugs of bisthiazolium salts are orally potent antimalarials. (2004)

We created neutral antimalarial prodrugs that deliver bisthiazolium compounds with antimalarial activity in the nanomolar range. These drugs primarily affect early intraerythrocytic stages through rapid, nonreversible cytotoxicity. The compounds are suitable for both parenteral and oral use and plasma promotes rapid conversion of the prodrug into the drug. We demonstrate that very low doses offer protection in a murine model of malaria. The drugs show great potential for curing high parasitemia with short-course treatments. Oral administration of the TE3 prodrug completely cures Plasmodium cynomolgi infection in rhesus monkeys. The drugs specifically accumulate inside infected erythrocytes, block phosphatidylcholine biosynthesis, and interact with hemozoin. To our knowledge, this class of compounds represents one of the most potent antimalarials tested to date. These unique properties signal a promising future for this class of antimalarial. PMID: 15492221
Structure for time-varying paraunitary filter banks with perfect reconstruction (1993)

A perfect reconstruction structure for a time-varying FIR paraunitary filter bank is developed, based on a known factorisation procedure. It allows the implementation of any uniform paraunitary filter bank, as well as distortion-free switchings from one filter bank to another.
Highly Enantioselective Control of Dynamic Cascade Transformations by Dual Catalysis: Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles (2015)

The highly enantioselective (up to >99.5:0.5 er) synthesis of polysubstituted spirocyclic oxindoles with four new contiguous stereocenters, including the spiro all-carbon quaternary center, is disclosed. It is accomplished by the highly stereoselective control of a dynamic conjugate/intramolecular allylic alkylation relay sequence based on the synergistic cooperation of metal and chiral amine catalysts in which the careful selection of organic ligand, metal complex, and chiral amine is essential. The intramolecular C–C bond-forming step occurred only when both the metal and chiral amine catalysts were present.
Synthetic loading of machines using microprocessor controlled power electronics (1990)

The authors describe methods of loading three-phase induction motors, using microprocessor controlled power electronic techniques and without the need to connect a load to the machine's drive shaft. Two methods are described, one method uses microprocessor controlled power electronics to generate the two distinct frequencies and thereby replace the electrical machines of the existing equivalent load technique. The second method uses microprocessor controlled power electronics to rapidly change the machine's supply frequency. If full load temperature rise is measured using the two methods described, results are obtained which are close to those measured when using a convectional generator load.
ChemInform Abstract: Acetogenic Isoquinoline Alkaloids. Part 21. An Atropisomer‐ Differentiating Reaction for the Chemical Analysis of Axial Chirality and Its Computational Investigation: Proof of the Stereostructure of Dioncophylline A. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Centrality dependence ofπ,K, andpproduction in Pb-Pb collisions atsNN=2.76TeV (2013)

In this paper measurements are presented of ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}$, ${K}^{\ifmmode\pm\else\textpm\fi{}}$, $p$, and $\overline{p}$ production at midrapidity ($|y|&lt;0.5$), in Pb-Pb collisions at $\sqrt{{s}_{NN}}=2.76$ TeV as a function of centrality. The measurement covers the transverse-momentum (${p}_{T}$) range from 100, 200, and 300 MeV/$c$ up to 3, 3, and 4.6 GeV/$c$ for $\ensuremath{\pi}$, $K$, and $p$, respectively. The measured ${p}_{T}$ distributions and yields are compared to expectations based on hydrodynamic, thermal and recombination models. The spectral shapes of central collisions show a stronger radial flow than measured at lower energies, which can be described in hydrodynamic models. In peripheral collisions, the ${p}_{T}$ distributions are not well reproduced by hydrodynamic models. Ratios of integrated particle yields are found to be nearly independent of centrality. The yield of protons normalized to pions is a factor $\ensuremath{\sim}$1.5 lower than the expectation from thermal models.
Cost-efficient anthropomorphic head phantom for quantitative image quality assessment in cone beam CT (2022)

In this study, a novel anthropomorphic head phantom for quantitative image quality assessment in cone beam computed tomography (CBCT) is proposed. The phantom is composed of tissue equivalent materials (TEMs) which are suitable for cost-efficient fabrication methods such as silicone casting and 3D printing. A monocalcium phosphate/gypsum mixture (MCPHG), nylon and a silyl modified polymer gel (SMP) are proposed as bone, muscle and brain equivalent materials respectively. The TEMs were evaluated for their radiodensity in terms of Hounsfield Units (HU) and their x-ray scatter characteristics. The median radiodensity and inter quartile range (IQR) of the MCPHG and SMP were found to be within the range of the theoretical radiodensity for bone and brain tissue: 922 (IQR = 156) and 47 (IQR = 7) HU respectively. The median radiodensity of nylon was slightly outside of the HU range of muscle tissue, but within the HU range of a combination of muscle and adipose tissue: -18 (IQR = 40) HU. The median ratios between the measured scatter characteristics and simulated tissues were between 0.84 and 1.13 (IQR between 0.05 and 0.14). The preliminary results of this study show that the proposed design and TEMs are potentially suitable for the fabrication of a cost-efficient anthropomorphic head phantom for quantitative image quality assessment in CT or CBCT.
ChemInform Abstract: Cerium Chloride‐Promoted Unusual Coupling Reactions of Alkenyl Grignard Reagents and Alkenyllithiums. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Systemic Lupus Erythematosus Endophenotype Characterized by Increased CD8 Cytotoxic Signature Associates with Renal Involvement (2017)

Abstract Systemic lupus erythematosus (SLE) is a highly heterogeneous disease with limited therapeutic options, where clinical manifestations are the result of activation of innate and adaptive immune mechanisms. The elucidation of these mechanisms is critical for identifying novel therapeutic targets and agents that are more likely to benefit individual patients. In this study we investigated the role that CD8+ T cells play in SLE. We studied CD8+ T cell activity in two different cohorts of SLE patients under standard of care (n = 65 total). The analyses included phenotyping of T cell differentiation, intracellular cytokine staining, and whole blood gene expression. We identified a subset of SLE patients (between 30 and 45%) with elevated numbers of terminally differentiated CD8+ T cells, identified as CCR7−CD45RAint-hiCD28−. We refer to this phenotype as cytotoxic, as it is accompanied by an increase in perforin and granzyme B expression and is correlated with a whole blood gene module of cytotoxic activity (p &amp;lt; 5 × 10−9). Consistent with the potential for tissue damage, this cytotoxic phenotype associates with lupus nephritis (p &amp;lt; 0.02). We have identified an SLE endophenotype, characterized by the increase in terminally differentiated CD8+ T cells that correlated with cytotoxic signature and renal manifestations of the disease. These findings suggest that this subgroup of SLE patients may benefit specifically from therapies that block CD8+ T cell activation and differentiation.