gebhart/patrepeval huggingface dataset:
Phenotypic and functional characterization of in vivo tissue engineered smooth muscle from normal and pathological bladders. (2002)

Tissue engineered muscle from normal and diseased bladders retain their phenotype in vitro and after implantation in vivo. The cells exhibited the same degree of contractility to electrical and chemical stimulation regardless of their origin. These results suggest that there are no phenotypic or functional differences between muscle cells obtained from urodynamically normal or pathological bladders, and that bladder muscle cells, regardless of their origin, may have the potential to be engineered into normal bladder tissues.
Roles for UDP-GlcNAc 2-Epimerase/ManNAc 6-Kinase outside of Sialic Acid Biosynthesis (2006)

Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase (GNE) beyond controlling flux into the sialic acid biosynthetic pathway by converting UDP-GlcNAc to N-acetylmannosamine are described in this report. Overexpression of recombinant GNE in human embryonic kidney (HEK AD293) cells led to an increase in mRNA levels for ST3Gal5 (GM3 synthase) and ST8Sia1 (GD3 synthase) as well as the biosynthetic products of these sialyltransferases, the GM3 and GD3 gangliosides. Conversely, down-regulation of GNE by RNA interference methods had the opposite, but consistent, effect of lowering ST3Gal5 and ST8Sia1 mRNAs and reducing GM3 and GD3 levels. Control experiments ensured that GNE-mediated changes in sialyltransferase expression and ganglioside biosynthesis were not the result of altered flux through the sialic acid pathway. Interestingly, exogenous GM3 and GD3 also changed the expression of GNE and led to reduced ST3Gal5 and ST8Sia1 mRNA levels, demonstrating a reciprocating feedback mechanism where gangliosides regulate upstream biosynthetic enzymes. Cellular responses to the GNE-mediated changes in ST3Gal5 and ST8Sia1 expression and GM3 and GD3 levels were investigated next. Conditions that led to reduced ganglioside production (e.g. short hairpin RNA exposure) stimulated proliferation, whereas conditions that resulted in increased ganglioside levels (e.g. recombinant GNE and exogenous gangliosides) led to reduced proliferation with a concomitant increase in apoptosis. Finally, changes to BiP expression and ERK1/2 phosphorylation consistent with apoptosis and proliferation, respectively, were observed. These results provide examples of specific biochemical pathways, other than sialic acid metabolism, that are influenced by GNE.
Interactions between carotid body denervation and renal nerve denervation in lowering arterial blood pressure in the adult spontaneously hypertensive rat (SHR) (2013)

We have previously shown that bilateral carotid body denervation (CBD) in SHR reduces arterial pressure (AP). How CBD interacts with the more established technique of renal denervation (RDNX) is unknown. Here we test the hypothesis that CBD will lower AP over and above the fall in pressure achieved with RDNX. In 12 week‐old SHR previously instrumented to record AP telemetrically, denervation surgery (unilateral CBD n=6; bilateral CBD n=7; Sham CBD n=6; RDNX n=5; Sham RDNX n=5) was performed on Day 0. On Day 21 after CBD or Day 14 after RDNX, the renal nerves or carotid bodies were denervated respectively. Chemoreflex elimination was confirmed by i.v. sodium cyanide (120ìg.kg‐1; Sham 15±3mmHg, CBD 1±2mmHg). By Day 21 after bilateral CBD, AP was reduced by −17±2 mmHg from a baseline of 160±5 mmHg (p&lt;0.05); unilateral CBD/Sham rats showed the expected developmental increase in AP of 7±2mmHg/9±3mmHg. Subsequent RDNX reduced AP by a further −8±2mmHg in bilateral CBD rats and by −8±3mmHg in Sham rats (p&lt;0.05). Conversely, in RDNX rats (−7±2mmHg), bilateral CBD produced a further fall in AP of −12±3 mmHg(p&lt;0.05). In summary, unilateral CBD alone seems insufficient to reduce AP in SHR. Bilateral CBD and RDNX appear to have an occlusive interaction. This is important clinically as it suggests further reductions in AP may be obtained in hypertensive patients post renal denervation. Supported by the British Heart Foundation and Cibiem.
Hairpin configuration of H-2Kk in liposomes formed by detergent dialysis (1984)

H-2Kk is a transmembrane glycoprotein having the N-terminal region of the heavy chain exposed at the cell surface and the C-terminal region exposed at the cytoplasmic face in its native configuration in the plasma membrane. The configuration of H-2Kk in liposomes formed by detergent dialysis was investigated by using fluorescently labeled H-2 and Co2+ ions to quench fluorescence. H-2Kk was incorporated into sealed lipid vesicles when deoxycholate was removed by dialysis from a mixture of protein and lipid. Including 20 mM carboxyfluorescein (CF) in the mixture prior to dialysis resulted in CF trapped inside the vesicles at concentrations where self-quenching occurred. Vesicles with CF trapped inside were shown to be osmotically active and impermeable to Na+ and Co2+ ions. In order to examine the configuration of H-2Kk in these liposomes, the heavy chain was covalently labeled by using the sulfhydryl reactive fluorescent reagents fluorescein-5-ylmaleimide (NFM) or 5-[[2-[(iodoacetyl)amino]-ethyl]amino]naphthalene-1-sulfonic acid (IAEDANS). In both cases, approximately equal amounts of fluorescent label were incorporated into the N- and C-terminal regions of the protein. Incorporation of the labeled H-2 into liposomes and examination of the effect of Co2+ on the fluorescence showed that all of the label was accessible to quenching by Co2+ and thus exposed on the outside of the liposome. The results demonstrate that the H-2Kk is incorporated into these liposomes in a hairpin configuration, not in the transmembrane configuration found in native membranes.(ABSTRACT TRUNCATED AT 250 WORDS)
Pulsed parametric array revisited (1982)

In a previous paper [J. Acoust. Soc. Am. Suppl. 1 71, S30 (A)] we presented the results of an investigation of the pulsed parametric array. We found that while the primary pulse exited the transducer a sum and difference frequency signal was scattered. However, once the interaction region was freely propagating (i.e., both boundaries moving at the sound speed) no further scattered signal was generated. This results in the observed scattered signal having a pulse length equal to the primary pulse length and the appearance of direct radiation from the face of the transducer. We also concluded that the directivity pattern, identical to the cw parametric array, was not due to a volume distribution of virtual sources. On re-examination this conclusion has been found to be incorrect. In this paper we demonstrate that the observed signal at a given farfield point is generated by a volume distribution of virtual sources, as long as contributions to the field at that point are still being received from the stationary boundary. Once signals from the stationary boundary cease there is no further scattering to that point. The extent of the scattering region is dependent upon the primary pulse length and the observation angle and is given by Leff = L/(1 − cos φ), where L is the primary pulse length and φ is the observation angle. This result may have some practical applications.
Comparison of epinephrine and vasopressin in a pediatric porcine model of asphyxial cardiac arrest (2000)

Administration of epinephrine, either alone or in combination with vasopressin, significantly improved left ventricular myocardial blood flow during cardiopulmonary resuscitation. Return of spontaneous circulation was significantly more likely in epinephrine-treated pigs than in animals resuscitated with vasopressin alone.
New SIMO single-carrier waveform designing for interference mitigation and high Doppler multipath environment (2009)

In this paper, we present a single-carrier (SC) waveform with smart antenna and frequency domain equalization (FDE) technologies to effectively combat both urban multipath and radio interference. It is designed to be power efficient, spectrally efficient, high quality, and capable of operating at vehicular speeds with long range. It can work on a small form factor device to support transport of streaming video as well as command and control messaging.
Myocardial Magnetic Resonance Imaging Contrast Agent Concentrations After Reversible and Irreversible Ischemic Injury (2002)

Regional elevations in myocardial MRI contrast agent concentrations are exclusively associated with irreversible ischemic injury defined histologically and by regional electrolyte concentrations.
Ubiquinol Supplementation of Donor Tissue Enhances Corneal Endothelial Cell Mitochondrial Respiration (2020)

Preliminary testing in donor corneal tissue at specified doses indicates that ubiquinol may be a useful biocompatible additive to hypothermic corneal storage media that increases corneal endothelial cell mitochondrial function. Additional investigations are indicated to further study and optimize the dose and formulation of ubiquinol for use in preserving donor corneal tissue function during hypothermic storage.
Measurement of Capsular Contracture (1989)

At present, there is no accurate, reliable method of experimentally measuring capsular contracture. This study had four goals: (1) to define the parameters of capsular contracture employing principles of biomechanics of soft tissues, (2) to develop laboratory techniques to measure the parameters, (3) to design an implant that mechanically impedes the process of encapsulation, and, (4) to test this implant against a conventional one. We have developed a breast implant (the Pittsburgh implant) with an altered surface topography. Its silicone shell is punctuated by projections 1 mm in height and 1 mm in diameter. Two techniques were devised to measure contracture. The first involved measuring the force deformation along a coronal axis. The second involved measuring hydrostatic pressures within the implant resulting from the injection of known quantities of saline. Measurements were performed in vivo on 36 animals. By both force and pressure measurements, the Pittsburgh implant showed less capsular contracture (p = 0.12 and 0.012, respectively). Histology revealed that the prototype surface alters the linear arrangement of myofibroblasts and redirects the laminar collagen into a waveform pattern. We conclude from this experimental study that an altered surface topography may serve as a means of rendering a capsule less mechanically effective. We feel that the proposed methods can be used in the laboratory to characterize the extent of capsular contracture.
Generation of antibody-based therapeutics targeting the idiotype of B-cell malignancies (2018)

Our results establish the utility of using engrafted CDR3 sequences for selecting phage that recognize the idiotype of B-cell tumors.
On uniformity and non-local transport in low pressure capacitively coupled plasmas (2020)

Abstract Low pressure (&lt;30 mTorr) capacitively coupled plasmas (CCP) are important for many plasma processing applications. Due to high energy of electrons in these plasmas and long electron mean free path, kinetic phenomena dominate the electron behavior. A multi-dimensional particle-in-cell (PIC) model is utilized to study the physics of sub-100 mTorr Ar CCPs in this article. A one-dimensional model for helium plasma in the 30–300 mTorr pressure range is first used to benchmark the PIC code against published results by Turner et al [2013 Phys. Plasmas 013507]. The article then focuses on two-dimensional modeling of the gaseous electronics conference (GEC) reference cell in cylindrical geometry. Computed ion density and DC bias voltage at 100 mTorr are compared to available experimental data for a range of radio frequency voltages, demonstrating good agreement. The validated model is used to examine Ar plasmas in the GEC reference cell in the 12.5–100 mTorr pressure range. It is found that the peak in ion and electron densities is near the electrode edge at 100 mTorr due to strong electric field there. As the gas pressure decreases, the peak in plasma density moves to the chamber center. This change in plasma spatial profile is linked to kinetic behavior of electrons, both regarding plasma production and transport in the plasma. Time-dependent results are used to illustrate that electron current at 25 mTorr is mainly kinetic and carried by beam electrons generated by expanding sheaths.
Cloning and Sequence Analysis of the 10 kDa Antigen Gene of Mycobacterium tuberculosis (1989)

The gene encoding a major protein antigen of Mycobacterium tuberculosis has been cloned and sequenced using oligonucleotide probes derived from the N-terminal sequence of the analogous protein from Mycobacterium bovis BCG. The gene analysis revealed a sequence encoding a protein of 99 amino acid residues, with a molecular mass of 10.7 kDa. Computer prediction suggests that the protein contains three T-cell-determined epitopes (of which one has been demonstrated experimentally) and three B-cell-determined epitopes. The protein sequence was homologous to two prokaryote heat-shock proteins and the gene possessed heat-shock-like promoter sequences upstream of the initiation codon. A hairpin loop identified in the upstream sequence may also be important in regulation of the gene.
A Dual-Band Millimeter-Wave Direct-Conversion Transmitter With Quadrature Error Correction (2014)

The analysis and implementation of a dual-band direct-conversion millimeter-wave transmitter is presented. The proposed dual-band modulator uses high-impedance loads at two frequencies for the local oscillator driving amplifiers and power amplifier (PA) pre-amplifiers. To correct the amplitude and phase imbalance of the in-phase and quadrature channels at Q- and W-bands, the paper suggests a digitally controlled quadrature error correction stage to finely calibrate these errors and lower the error vector magnitude (EVM) without increasing the baseband digital-to-analog converter resolution. The transmitter is fabricated in 0.12- μm silicon-germanium BiCMOS process and occupies an area of 5.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . At 45-GHz carrier frequency, error correction improves the sideband suppression ratio (SSR) by 10 dB at 2.4-MHz IF frequency. The EVM is lowered from 3.21% to 2.38% for a 64-QAM constellation at a 2.4-Ms/s symbol rate. At 94-GHz carrier frequency, the SSR is improved from 24 to 41 dBc at 2.4-MHz IF frequency, and the EVM is lowered by more than 1% for a 16-QAM constellation at 3-Ms/s symbol rate. A dual-band PA breakout measurement indicates the peak power-added efficiency of 15% with 14-dBm maximum saturated power (Psat) at 43 GHz and 9-dBm Psat at 82 GHz is achieved.
All-fiber Kerr wavelength converter (1998)

Summary form only given. The authors present a novel fibre wavelength converter architecture based on the joint use of Kerr phase modulation and interferometric conversion where drawbacks are greatly reduced. The proposed interferometric architecture maintains all the advantages of the Kerr effect band phase modulation in fiber while assuring a very low operation noise.
Sex-related characteristics and short-term outcomes of patients undergoing transcatheter tricuspid valve intervention for tricuspid regurgitation (2022)

After TTVI in high-risk patients, there were no sex-related differences in terms of survival, HF hospitalization, functional status, and TR reduction up to 1 year. The IPTW analysis shows a survival benefit of TTVI over medical therapy alone in both women and men.
Ability to Cope with Pain Puts Migraine Surgery Patients in Perspective (2017)

Therapeutic, IV.
Mineralization of dimethylsilanediol by microorganisms isolated from soil (1999)

Abstract Previous studies have shown that polydimethylsiloxane is hydrolyzed in soil to dimethylsilanediol and that dimethylsilanediol is biodegraded in soil. Previously, two soil microorganisms capable of biodegrading dimethylsilanediol were isolated and identified. In this paper, the extent of [14C]dimethylsilanediol biodegradation by these two soil microorganisms, Fusarium oxysporum Schlechtendahl and an Arthrobacter species, is investigated. The silicon-containing products of dimethylsilanediol biodegradation in liquid culture were identified by high-performance liquid chromatography coupled to argon plasma emission spectrometry (HPLC-ICP). The biodegradation of [14C]methylsilanetriol was investigated in liquid cultures and in soil by monitoring the production of 14CO2. The sorption coefficient of [14C]methylsilanetriol was determined, and the sorption coefficient of [14C]dimethylsilanediol was estimated, by measuring the amount of 14C counts in the water phase of a water-soil mixture. Methylsilanetriol was found to be mineralized in liquid cultures of F. oxysporum Schlecht. and the Arthrobacter sp. that were supplied with a primary carbon source. However, the production of 14CO2 from [14C]methylsilanetriol in soil experiments never exceeded the level of possible [14C]-containing impurities in the methylsilanetriol. Methylsilanetriol was found to be more strongly sorbed to soil, which might have reduced its bioavailability. Previous evidence has shown that polydimethylsiloxane is hydrolyzed in soil to the monomer dimethylsilanediol, which is biodegraded in soil. Now mineralization of dimethylsilanediol to inorganic silicate has been demonstrated.
Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilisSharon T. Cload, David R. Liu, Richard M. Pastor, and Peter G. SchultzView Author Information Howard Hughes Medical Institute, Department of Chemistry University of California, Berkeley, California 94720Cite this: J. Am. Chem. Soc. 1996, 118, 7, 1787–1788Publication Date (Web):February 21, 1996Publication History Received13 September 1995Published online21 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja953152ghttps://doi.org/10.1021/ja953152grapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views602Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Hydroxyls,Monomers,Peptides and proteins,Potassium,Transition states Get e-Alerts
Impact of tolerances in dielectric properties of hand phantoms (2010)

Hand phantoms are increasingly important in assessing the communication performance of handsets. A parametric study on tolerances of the material properties of hand phantoms is performed, showing that small variations of both relative permittivity and conductivity with respect to their nominal values hardly affect absorption and mismatch loss.
P450 Electron Transfer Reactions (2007)

This chapter contains sections titled: Introduction Catalytic Cycles Electron Tunneling Wires Concluding Remarks Acknowledgments Abbreviations References
Correlation-based Arrangement of Time Series for Movement Analysis in Behavioural Ecology (2012)

The collection and analysis of animal movement data has the potential to address important questions about evolution, ecology, and global change. However, showing the “right ” information to recognize dependencies between different measurements and to derive valuable information from these data remains a challenge. To simplify
Enhanced Current Efficiency from Bio-Organic Light-Emitting Diodes Using Decorated Amyloid Fibrils with Conjugated Polymer (2008)

We demonstrate the use of self-assembled bionanostructures in polymer light-emitting diodes. Amyloid fibrils formed by protein misfolding were decorated with a soluble luminescent conjugated polymer. This conjugated polymer complex with amyloid fibrils was used as the active layer in a light emitting diode, resulting in a 10-fold increase in external quantum efficiency compared with pristine polymer, because of improved carrier injection.
[Viajes de James Cook] [Material gráfico] (2013)

Posible estampa suelta de: Historia de la vida y viages del capitan Jaime Cook / Obra escrita en ingles por Andrew Kippis y ... trad. por D.C. de Nava Palacio
Room-Temperature, High-Yield Route to Poly(n-alkylmethylsilane)s and Poly(di-n-hexylsilane) (2005)

The synthesis of poly(n-hexylmethylsilane) in crude yields from 50 to 83% and poly(di-n-hexylsilane) in crude yields from 67 to 82%, was accomplished by performing Wurtz-type reductive-coupling polymerizations of the corresponding dicholorodiorganosilanes in THF at room temperature. After purification, both polymers were obtained in isolated yields of greater than 50%, which are the highest achieved for such polysilanes to date. The general applicability of the synthetic procedure was also demonstrated by syntheses of poly(methyl-n-octylsilane) and poly(methyl-n-propylsilane) in good yields. The results indicate that the reductive coupling of dichlorodiorganosilanes in THF at room temperature offers not only greatly improved polymer yields but also provides a general route to polydiorganosilanes that is a considerable improvement on Wurtz-type syntheses carried out in toluene at 110 degreesC.
Precise Fracture Initiation Using Dynamic Fluid Movement Allows Effective Fracture Development in Deviated Wellbores (2000)

Abstract In deviated wellbores with long perforated intervals, conventional fracture initiation with wellbore pressurization often creates multiple fracture initiations, resulting in severe fracture tortuosity. When this happens, treatments are generally plagued with high injection pressures, low injection rates and, quite often, early screenouts. One solution to the problem of multiple fractures is to use the fluid’s own dynamic movement to divert flow to a specific point. This method accurately positions and directs fracture initiation. With proper planning, a single fracture can be initiated and proppant can be easily placed without tortuosity effects. This paper discusses the use of the dynamic fluid movement treatment in a well positioned on an incline through the pay section. Premature screenout had occurred when proppant first entered the formation on a previous treatment attempt, and fracture modeling indicated that multiple fractures were the apparent cause of the screenout. When the dynamic fluid movement method was used on a subsequent treatment, a fracture was initiated properly, and a large proppant treatment was placed successfully.
Preventing RFIC interference issues: A modeling methodology for floorplan development and verification of isolation- and grounding strategies (2011)

In order to prevent interference issues it is essential to make the right choices/trade-offs in the early phases of the IC design. A modeling methodology was developed to study the impact of physical design choices on the isolation behavior of the overall packaged and mounted RF product. This paper gives an overview of the various coupling paths and their relative contribution in the isolation/coupling. The simulation/modeling results are in good agreement with measurements.