gebhart/patrepeval huggingface dataset:
OP23 Efficacy and safety of upadacitinib as induction therapy in patients with Moderately to Severely Active Ulcerative Colitis: Results from phase 3 U-ACCOMPLISH study (2021)

Abstract Background Upadacitinib (UPA) is a selective and reversible Janus kinase inhibitor.U-ACCOMPLISH is one of two phase 3 induction trials that evaluated the safety and efficacy of UPA 45 mg once daily (QD) in adults with ulcerative colitis (UC). Methods U-ACCOMPLISH was a multicentre, randomized, double-blind, placebo-controlled trial (NCT03653026) that enrolled patients with moderate-to-severe UC (defined as adapted Mayo score 5–9 with centrally read endoscopic score 2–3) who had inadequate response, loss of response, or intolerance to aminosalicylates, immunosuppressants, corticosteroids and/or biologics. Patients were randomized 2:1 to UPA 45 mg QD or placebo (PBO) for 8 weeks. At week 8, responders entered the maintenance phase and non-responders entered the extended treatment period to receive open-label UPA 45 mg QD for additional 8 weeks.The primary endpoint (clinical remission per adapted Mayo Score) and ranked secondary endpoints including symptomatic, endoscopic– histologic evaluations from the 8-week PBO-controlled period are reported here. Non-responder imputation incorporating multiple imputation for missing data due to COVID-19 are reported. Results 522 patients were randomized (UPA, n=345; PBO, n=177); the intent-to-treat population included 341 patients in UPA and 174 patients in PBO group. Baseline demographics and disease characteristics were similar between groups; 50.7% and 51.1% were biologic inadequate responders in UPA and PBO groups, respectively (Table 1). A significantly higher proportion of patients receiving UPA 45 mg QD (33.5%) versus PBO (4.1%) achieved the primary endpoint (adjusted treatment difference: 29.0% [23.2, 34.7]; P&amp;lt;0.001). A significantly higher proportion of patients receiving UPA versus PBO also achieved all ranked secondary endpoints (all P&amp;lt;0.001; Figure 1).Serious adverse events were reported by 3.2% and 4.5% of patients in UPA and PBO groups, respectively (Table 2). Similar rates of serious infection were observed in both groups (0.6%); 2 events each of herpes zoster and opportunistic infection were reported in UPA group. No active tuberculosis, malignancy, adjudicated major adverse cardiovascular events, or deaths were reported in the study. One patient with venous thromboembolism (deep vein thrombosis and pulmonary embolism) and 1 patient with gastrointestinal perforation were reported in the placebo group. Conclusion In U-ACCOMPLISH, 8-week UPA 45 mg QD induction treatment led to statistically significant improvements in clinical, endoscopic, and combined endoscopic-histologic endpoints. The treatment was well tolerated, and the safety profile and AE prevalence was comparable with previous studies of UPA with no new safety signals identified.
Improving BGP Convergence Delay for Large-Scale Failures (2006)

Border gateway protocol (BGP) is the standard routing protocol used in the Internet for routing packets between the autonomous systems (ASes). It is known that BGP can take hundreds of seconds to converge after isolated failures. We have also observed that the convergence delay can be even greater for large-scale failures. In this study, we first investigate some of the factors affecting the convergence delay and their relative impacts. We observe that the minimum route advertisement interval (MRAI) and the processing overhead at the routers during the re-convergence have a significant effect on the BGP recovery time. We propose a couple of new schemes to reduce processing overload at BGP routers during large failures, which in turn leads to decreased convergence delays. We show that these schemes combined with the tuning of the MRAI value decrease the BGP convergence delay significantly, and can thus limit the impact of large scale failures in the Internet
Finite Element Method (2006)

No AccessPolymer ProcessingApr 2006Finite Element MethodTim A. Osswald, Juan P. Hernández-OrtizTim A. OsswaldSearch for more papers by this author, Juan P. Hernández-OrtizSearch for more papers by this authorhttps://doi.org/10.3139/9783446412866.009SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2006Pages: 453-509Print ISBN: 978-3-446-40381-9eISBN: 978-3-446-41286-6 Copyright & Permissions© 2006 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Web search using mobile cores (2010)

The commoditization of hardware, data center economies of scale, and Internet-scale workload growth all demand greater power efficiency to sustain scalability. Traditional enterprise workloads, which are typically memory and I/O bound, have been well served by chip multiprocessors com- prising of small, power-efficient cores. Recent advances in mobile computing have led to modern small cores capable of delivering even better power efficiency. While these cores can deliver performance-per-Watt efficiency for data center workloads, small cores impact application quality-of-service robustness, and flexibility, as these workloads increasingly invoke computationally intensive kernels. These challenges constitute the price of efficiency. We quantify efficiency for an industry-strength online web search engine in production at both the microarchitecture- and system-level, evaluating search on server and mobile-class architectures using Xeon and Atom processors.
Neutron imaging of lithium concentration in battery pouch cells (2011)

This paper shows how the principle of neutron radiography can be used to quantify the critical physical state of lithium concentration across battery electrodes at steady-state conditions (after a long relaxation time or small load) as a first step in this important effort to measure in-situ battery physical states and validate electrochemical battery models. A model of the expected loss in beam intensity after passing through the different layers of a battery pouch cell is constructed based on the material densities and dimensions. This model is augmented with simulation of the neutron transmission behavior, including optical effects due to the geometric unsharpness and the detector response. The resulting model provides the basis for a comprehensive simulation of the in-situ metrology of lithium concentration in Li-ion batteries, and comparison with experimental results. This work was also presented as a poster at the 27th Annual Army Science Conference [1].
The Role of Fundamental Research and Biotechnology in Finding Solutions to the Global Problem of Antibiotic Resistance (1997)

Resistance to antibiotics is becoming a major problem worldwide. Exacerbating this situation is the fact that few new antibiotics are in the development pipeline, and, indeed, no novel class of antibiotics has been introduced into medical practice in more than 20 years. It is proposed that the solutions to the problem of antibiotic resistance will be found only through fundamental research that will probably use biotechnology as a tool. A variety of novel approaches being utilized in university laboratories and biotechnology companies are outlined. Two approaches in particular, namely, Synsorbs and recombinant cationic peptide antimicrobials, that have been developed through the Canadian Bacterial Diseases Network, a national research consortium, are discussed.
Synthesis of Chiral Indolizines as Bicyclic Ergoline Analogues (1991)

An efficient of the enantiomerically pure aminoindolizine (3) by a triflic anhydride assisted cyclization of 1,3-amino alcohol (6) is reported. 6 can be readily derived from L-asparagine (4) via the O-activated β-homoserine equivalent (7)
Impedimetric Characterization of Bioelectronic Nano-Antennae (2020)

The merging of electronics with biology at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nano-bioelectronics will facilitate development and enable applications in biosensing, tissue engineering and bioelectronic medicine. However, studies investigating the electrical effects when merging wireless conductive nanoelectrodes with biology are lacking. Consequently, a new tool is required to develop a greater understanding of the bioelectrical effects of merging conductive nanoparticles with biology. Herein, this challenge is addressed by developing an impedimetric method to evaluate bipolar electrochemical systems (BESs) that could act as nano-antennas. A theoretical framework is provided, using impedance to determine if conductive nanoparticles can be polarized and used to drive current. It is then demonstrated that 125 nm Au nanoparticle bipolar electrodes (BPEs) could be sensed in the presence of biology when incorporated intracellularly at 500 mg/ml, using water and PBS as electrolytes. These results highlight how nanoscale BPEs act within biological systems and characterize their behavior in electric fields. This research will impact on the rational design of using BPE systems in biology for both sensing and actuating applications.
A distributed and collaborative scheme for mitigating coexistence in IEEE 802.15.4 based WBANs (2012)

Wireless Body Area Networks (WBANs) comprise a fast growing technology that enables remote monitoring of vital signs and is aimed at providing support for healthcare services. These systems normally use low-power wireless technologies, such as IEEE 802.15.4, which are limited in bandwidth and range. The dense population of patients in places like hospitals is likely to raise situations where the coexistence of multiple WBANs results in severe loss of performance and functionality. Therefore providing coexistence mitigation mechanisms for this kind of systems is a necessity. In this paper, we present the performance analysis of a simulated mechanism designed to mitigate the harmful effects of coexistence on the operation of IEEE 802.15.4 based WBANs. The distributed and collaborative design of this scheme makes it well suited for typical healthcare applications. The proposed mechanism detects the coexistence situation and reorganizes the communication of the coexisting WBANs. We implement the proposed scheme and show the simulation results using OPNET.
Complications during root canal irrigation – literature review and case reports (2000)

LITERATURE REVIEW AND CASE REPORTS: The literature concerning the aetiology, symptomatology and therapy of complications during root canal irrigation is reviewed. Three cases of inadvertent injection of sodium hypochlorite and hydrogen peroxide beyond the root apex are presented. Clinical symptoms are discussed, as well as preventive and therapeutic considerations.
The Effect of Functional Group Polarity in Palladium Immobilized Multiwalled Carbon Nanotube Catalysis: Application in Carbon-Carbon Coupling Reaction (2018)

Carbon nanotubes (CNTs) are effective supports for nano metals and together they represent hybrids that combine unique properties of both. A microwave induced reaction was used to deposit nano palladium on carboxylated and octadecylamine functionalized multiwall CNTs, which were used to carry out C-C coupling reactions in DMF and toluene. These hybrids showed excellent catalytic activity with yield as high as 99.8% while its enhancement with respect to commercially available Pd/C catalyst reached as high as 109%, and the reactions times were significantly lower. Polarity of the functionalized form was found to be a significant factor with the polar carboxylated CNT showing better activity in DMF while the relatively nonpolar octadecyl amine was better in toluene. The results suggest the possibility of tailor making functionalized CNT when used as catalyst supports
Fatty Acid Cysteamine Conjugates as Novel and Potent Autophagy Activators That Enhance the Correction of Misfolded F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (2016)

A depressed autophagy has previously been reported in cystic fibrosis patients with the common F508del-CFTR mutation. This report describes the synthesis and preliminary biological characterization of a novel series of autophagy activators involving fatty acid cysteamine conjugates. These molecular entities were synthesized by first covalently linking cysteamine to docosahexaenoic acid. The resulting conjugate 1 synergistically activated autophagy in primary homozygous F508del-CFTR human bronchial epithelial (hBE) cells at submicromolar concentrations. When conjugate 1 was used in combination with the corrector lumacaftor and the potentiator ivacaftor, it showed an additive effect, as measured by the increase in the chloride current in a functional assay. In order to obtain a more stable form for oral dosing, the sulfhydryl group in conjugate 1 was converted into a functionalized disulfide moiety. The resulting conjugate 5 is orally bioavailable in the mouse, rat, and dog and allows a sustained delivery of the biologically active conjugate 1.
A realistic trap distribution model for numerical simulation of amorphous silicon thin-film transistors and phototransistors (1995)

Numerical simulation of amorphous silicon phototransistors using the conventional trap distribution model is shown to give drain-to-source currents lower than experimentally reported values by about a factor of ten. Several attempts to optimize the semiconductor parameters to obtain a good agreement between the experimental and simulation data proved unsuccessful. We propose a more realistic model for the trap distribution which consists of both bulk traps and surface traps. Incorporating this model into a two-dimensional device simulator, simulation results in good agreement with experimental data are obtained for both thin-film transistors and phototransistors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Quality Snags in the Mortgage-Finance Supply Chain Comments-Responses (2009)

Prominent authorities in financial academics and quality management comment on the article, Quality Snags in the Mortgage-Finance Supply Chain by Paul Zipkin. John R. Latham of the Monford College of Business, University of Northern Colorado, writes on ..
Electrical properties for diagnosis of sulfide-tree growth in cables under dc stress (2002)

Electrical properties, that is, AC electric strength and DC conductivity, are measured at different aging times in cable models immersed in sea water with hydrogen sulfide and supplied at two voltage levels. Test conditions are studied in order to favour growth of electrochemical, or sulfide, trees. Cable models have copper conductor and polyethylene insulation. It is shown that both electric strength and conductivity significantly vary with tree-growth time, providing tools for cable degradation diagnosis.
ChemInform Abstract: Electron‐Deficient DNA‐Intercalating Agents as Antitumor Drugs: Aza Analogues of the Experimental Clinical Agent N‐(2‐(Dimethylamino)ethyl) acridine‐4‐carboxamide. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Somatostatin Analogs Modulate AIP in Somatotroph Adenomas: The Role of the ZAC1 Pathway (2012)

These results suggest that AIP may play a role in the mechanism of action of somatostatin analogs via ZAC1 in sporadic somatotroph tumors and may explain their lack of effectiveness in patients with AIP mutations.
Visualization Balloon Allows Successful Performance of Colonoscopy in Patients With Prior Documented Difficult Colon Anatomy: A Pilot Clinical Study (2014)

Introduction: Traditional colonoscopy with air or carbon dioxide (CO2) insufflation can be difficult in patients with long, redundant, and torturous colons. Insufflation of gas lengthens the colon and makes colonoscope navigation towards the cecum difficult and sometimes even impossible. A proprietary visualization balloon, (Vizballoon™) was recently introduced into clinical practice in the USA. Use of Vizballoon ™ eliminates the need for air or CO2 insufflation and facilitates advancement of the colonoscope through the colon. Methods: We performed Vizballoon™-assisted colonoscopies in patients with documented previous difficult colonoscopies. Prior to the start of the procedure, Vizballoon™ was inserted through the biopsy channel of adult colonoscope (CF 190, Olympus, Tokyo, Japan) and filled with 5 ml of water. Then the colonoscope with Vizballoon™ was inserted into the rectum and advanced without any gas insufflation until the cecum was reached. At this point the water was aspirated from the balloon and the Vizballoon™ was removed. The.CO2 was insufflated to optimize visualization of the colonic lumen during withdrawal of th Vizballoon™ e colonoscope. Results: Vizballoon™-assisted colonoscopies were performed in 4 consecutive patients with known previous difficult colonoscopies, performed in the past with CO2 insufflation. Previous colonoscopies in these patients required significant amount of external pressure and changes in patient position in order to reach the cecum. Technical difficulties during prior colonoscopies were caused by long, redundant colons (2 patients), and torturous colons with diverticuli and multiple fixed turns (2 patients). In all study patients the colonoscope with Vizballoon™ was easily advanced to the cecum (within 3.75-12 minutes) without any external pressure or change in patient position None of the study patients had any abdominal discomfort after colonoscopy. Conclusion: In patients with documented difficult colonic anatomy, use of the visualization balloon eliminates the need for gas insufflation during advancement to the cecum,. Balloon assistance makes colonoscopy technically easier, faster, and increases the likelihood of successfully reaching the cecum without the application of external pressure or change in patient position.
Pre- and post-compensation of dispersion and nonlinearities in 10-Gb/s WDM systems (1997)

We analyze 10-Gb/s nondispersion-managed and dispersion-managed wavelength-division multiplexed (WDM) systems that use pre-compensation, post-compensation, or dual-compensation of each channel to minimize dispersion and nonlinear effects. We find that dual-compensation gives the minimal penalty for each channel in dispersion-managed WDM systems. Furthermore, we find that the optimal amount of pre- or post-compensation depends upon the specific dispersion map used in the WDM system.
Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication (2023)

Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we synthesized and studied the antiviral properties of a novel nitrocatechol compound (<b>1c</b>) and other analogs that are structurally related to the catechol derivative dynasore. Interestingly, compound <b>1c</b> strongly inhibited two DEDD box viral ribonucleases, HIV-1 RNase H and SARS-CoV-2 nsp14 3'-to-5' exoribonuclease (ExoN). While <b>1c</b> inhibited SARS-CoV-2 ExoN activity, it did not interfere with the mRNA methyltransferase activity of nsp14. In silico molecular docking placed compound <b>1c</b> in the catalytic pocket of the ExoN domain of nsp14. Finally, <b>1c</b> inhibited SARS-CoV-2 replication but had no toxicity to human lung adenocarcinoma cells. Given its simple chemical synthesis from easily available starting materials, these results suggest that <b>1c</b> might be a lead compound for the design of new antiviral compounds that target coronavirus nsp14 ExoN and other viral ribonucleases.
Self-Tuning Power Supply for Inductive Charging (2016)

Inductive power transfer (IPT) systems for electric vehicle (EV) charging often have to operate under a wide range of coupling factors and loads, potentially mistuning the primary power supply. This is especially a problem in dynamic applications where the vehicles are moving. This paper investigates the design of a self-tuning power supply by utilizing a switchable bank of capacitors with a push-pull tuning topology. The proposed power supply is able to handle operation under a wide range of coupling factors and loading conditions while achieving ZVS operation at a fixed frequency. A mathematical model is developed to model the system and an experimental system is built to test the design. The experimental system is able to deliver a constant 1 kW over a coupling factor range of 0.1-0.33. A detection circuit to monitor the state of tuning of the power supply is presented along with a control scheme to maintain optimal tuning.
Synthesis of porous silica with hierarchical structure directed by a silica precursor carrying a pore-generating cage (2008)

We have obtained a new class of porous silica with good structural order and additional corrugated nanopores clustered around the primary mesopores from the co-condensation of TEOS and adamantylphenol-grafted trimethoxysilane (adam-graft SQ) using a triblock Pluronic P123 (EO20PO70EO20, Mw = 5800) copolymer as a structure-directing agent. Thermally activated removal of pore-generating moieties (i.e., adamantylphenol groups) in adam-graft SQ involves the generation of secondary micro-to-small mesopores, while the block copolymer template generates 2D-hexagonal mesopores. We found that the mesostructural characteristics and the generation of secondary indented pores right next to the mesopores can be tailored by the addition order of the two silica precursors (TEOS and adam-graft SQ), varying the molar ratio between TEOS and adam-graft SQ in the starting sol mixture, and the degree of silica polymerization. The increase in the hexagonal unit cell parameters is attributed to the increment of pore size originating from the removal of adamantylphenol moieties. It is believed that the hydrophobicity of adamantylphenol groups plays a key role in its selective incorporation into the region near the PPO core blocks and the subsequent generation of corrugated pores along the silica channels resulting in the increase of pore diameter.
A hidden-password online password manager (2021)

The most commonly adopted password management technique is to store web account passwords on a password manager and lock them using a master password. However, current online password managers do not hide the account passwords or the master password from the password manager itself, which highlights their real-world vulnerability and lack of user confidence in the face of malicious insiders and outsiders that compromise the password management service especially given its online nature. We attempt to address this crucial vulnerability in the design of online password managers by proposing HIPPO, a cloud-based password manager that does not learn or store master passwords and account passwords. HIPPO is based on the cryptographic notion of device-enhanced password authenticated key exchange proven by Jarecki et al. to resist online guessing attacks and dictionary attacks. We introduce the HIPPO protocol design and report on a full implementation of the system.
High-Speed Optical and Millimeter-Wave Wireless Link for Disaster Recovery (2015)

A government-funded R and D program aiming at a resilient optical and millimeter-wave wireless link for a novel span protection scheme in a disaster recovery is presented. We also describe the key enabling technologies of both optical and wireless sub- systems and devices, including MIMO radio-over- fiber system, optical two-tone generation, and the transceiver and power amplifier in W-band.