gebhart/patrepeval huggingface dataset:
Provisioning multi-tier cloud applications using statistical bounds on sojourn time (2012)

In this paper we present a simple and effective approach for resource provisioning to achieve a percentile bound on the end to end response time of a multi-tier application. We, at first, model the multi-tier application as an open tandem network of M/G/1-PS queues and develop a method that produces a near optimal application configuration, i.e, number of servers at each tier, to meet the percentile bound in a homogeneous server environment -- using a single type of server. We then extend our solution to a K-server case and our technique demonstrates a good accuracy, independent of the variability of service-times. Our approach demonstrates a provisioning error of no more than 3% compared to a 140% worst case provisioning error obtained by techniques based on an M/M/1-FCFS queue model. In addition, we extend our approach to handle a heterogenous server environment, i.e., with multiple types of servers. We find that fewer high-capacity servers are preferable for high percentile provisioning. Finally, we extend our approach to account for the rental cost of each server-type and compute a cost efficient application configuration with savings of over 80%. We demonstrate the applicability of our approach in a real world system by employing it to provision the two tiers of the java implementation of TPC-W -- a multi-tier transactional web benchmark that represents an e-commerce web application, i.e. an online bookstore.
Vaccination with novel low-molecular weight proteins secreted from Trichinella spiralis inhibits establishment of infection (2020)

Trichinella spiralis muscle stage larvae (mL1) produce excretory-secreted products (ESPs), a complex mixture of protein, which are believed to be important for establishing or maintaining an infection niche within skeletal muscle and the intestine. Studies of both whole ESPs and individual cloned proteins have shown that some ESPs are potent immunogens capable of eliciting protective immune responses. Here we describe two novel proteins, Secreted from Muscle stage Larvae SML-4 and SML-5 which are 15 kDa and 12 kDa respectively. The genes encoding these proteins are highly conserved within the Trichinellids, are constituents of mL1 ESP and localized in the parasite stichosome. While SML-5 is only expressed in mL1 and early stages of adult nematode development, SML-4 is a tyvosylated glycoprotein also produced by adult nematodes, indicating it may have a function in the enteral phase of the infection. Vaccination with these proteins resulted in an impaired establishment of adult stages and consequently a reduction in the burden of mL1 in BALB/c mice. This suggests that both proteins may be important for establishment of parasite infection of the intestine and are prophylactic vaccine candidates.
Toward 6G Networks: Use Cases and Technologies (2020)

Reliable data connectivity is vital for the ever increasingly intelligent, automated, and ubiquitous digital world. Mobile networks are the data highways and, in a fully connected, intelligent digital world, will need to connect everything, including people to vehicles, sensors, data, cloud resources, and even robotic agents. Fifth generation (5G) wireless networks, which are currently being deployed, offer significant advances beyond LTE, but may be unable to meet the full connectivity demands of the future digital society. Therefore, this article discusses technologies that will evolve wireless networks toward a sixth generation (6G) and which we consider as enablers for several potential 6G use cases. We provide a fullstack, system-level perspective on 6G scenarios and requirements, and select 6G technologies that can satisfy them either by improving the 5G design or by introducing completely new communication paradigms.
Compile-time and run-time optimizations for enhancing locality and parallelism on multi-core and many-core systems (2009)

Current trends in computer architecture exemplify the emergence of multiple processor cores on a chip. The modern multiple-core computer architectures that include general-purpose multi-core architectures (from Intel, AMD, IBM, and Sun), and specialized parallel architectures such as the Cell Broadband Engine and Graphics Processing Units (GPUs) have very high computation power per chip. A significant challenge to be addressed in these systems is the effective load-balanced utilization of the processor cores. Memory subsystem has always been a performance bottleneck in computer systems and it is more so, with the emergence of processor subsystem with multiple on-chip processor cores. Effectively managing the on-chip and off-chip memories and enhancing data reuse to maximize memory performance is another significant challenge in modern multiple-core architectures. 
Our work addresses these challenges in multi-core and many-core systems, through various compile-time and run-time optimization techniques. We provide effective automatic compiler support for managing on-chip and off-chip memory accesses, with the compiler making effective decisions on what elements to move in and move out of on-chip memory, when and how to move them, and how to efficiently access the elements brought into on-chip memory. We develop an effective tiling approach for mapping computation in regular programs on to many-core systems like GPUs. We develop an automatic approach for compiler-assisted dynamic scheduling of computation to enhance load balancing for parallel tiled execution on multi-core systems. 
There are various issues that are specific to the target architecture which need attention to maximize application performance on the architecture. First, the levels of parallelism available and the appropriate granularity of parallelism needed for the target architecture have to be considered while mapping the computation. Second, the memory access model may be inherent to the architecture and optimizations have to be developed for the specific memory access model. We develop compile-time transformation approaches to address performance factors related to parallelism and data locality that are GPU architecture-specific, and develop an end-to-end compiler framework for GPUs.
Mutations in SEC63 cause autosomal dominant polycystic liver disease (2004)

Mutations in PRKCSH, encoding the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER), cause autosomal dominant polycystic liver disease. We found that mutations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause this disease. These findings are suggestive of a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicate noncilial ER proteins in human polycystic disease.
ChemInform Abstract: A One‐Pot Bicycloannulation Method for the Synthesis of Tetrahydroisoquinoline Systems. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhanced quantum yield of photoluminescent porous silicon prepared by supercritical drying (2016)

The effect of supercritical drying (SCD) on the preparation of porous silicon (pSi) powders has been investigated in terms of photoluminescence (PL) efficiency. Since the pSi contains closely spaced and possibly interconnected Si nanocrystals (&amp;lt;5 nm), pore collapse and morphological changes within the nanocrystalline structure after common drying processes can affect PL efficiency. We report the highly beneficial effects of using SCD for preparation of photoluminescent pSi powders. Significantly higher surface areas and pore volumes have been realized by utilizing SCD (with CO2 solvent) instead of air-drying. Correspondingly, the pSi powders better retain the porous structure and the nano-sized silicon grains, thus minimizing the formation of non-radiative defects during liquid evaporation (air drying). The SCD process also minimizes capillary-stress induced contact of neighboring nanocrystals, resulting in lower exciton migration levels within the network. A significant enhancement of the PL quantum yield (&amp;gt;32% at room temperature) has been achieved, prompting the need for further detailed studies to establish the dominant causes of such an improvement.
Supplementary Table S1 from Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy (2023)

&lt;p&gt;Whole exome sequencing data, including somatic variants, purities, private mutations, and predicted neoantigens.&lt;/p&gt;
Spectral Graph Forge: Graph Generation Targeting Modularity (2018)

Community structure is an important property that captures inhomogeneities common in large networks, and modularity is one of the most widely used metrics for such community structure. In this paper, we introduce a principled methodology, the Spectral Graph Forge, for generating random graphs that preserves community structure from a real network of interest, in terms of modularity. Our approach leverages the fact that the spectral structure of matrix representations of a graph encodes global information about community structure. The Spectral Graph Forge uses a low-rank approximation of the modularity matrix to generate synthetic graphs that match a target modularity within user-selectable degree of accuracy, while allowing other aspects of structure to vary. We show that the Spectral Graph Forge outperforms state-of-the-art techniques in terms of accuracy in targeting the modularity and randomness of the realizations, while also preserving other local structural properties and node attributes. We discuss extensions of the Spectral Graph Forge to target other properties beyond modularity, and its applications to anonymization.
Percolation-Driven Multiscale Roughening for Superhydrophobic Polymer Nanocomposite Coatings (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPercolation-Driven Multiscale Roughening for Superhydrophobic Polymer Nanocomposite CoatingsShane E. Harton*†, Cynthia G. Templeman‡, and Brenda Vyletel§View Author Information† Materials Research Department, Toyota Research Institute of North America, Toyota Technical Center, Ann Arbor, Michigan 48105‡ Materials Engineering Division, Toyota Technical Center, Ann Arbor, Michigan 48105§ Electron Microbeam Analysis Laboratory, University of Michigan, Ann Arbor, Michigan 48109*To whom correspondence should be addressed. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 7, 3173–3176Publication Date (Web):March 10, 2010Publication History Received7 January 2010Revised5 March 2010Published online10 March 2010Published inissue 13 April 2010https://pubs.acs.org/doi/10.1021/ma100044qhttps://doi.org/10.1021/ma100044qrapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views1269Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Coating materials,Hydrophobicity,Nanocomposites,Nanoparticles,Surface roughness Get e-Alerts
Facile and Selective Aerobic Oxidation of Arylalkanes to Aryl Ketones Using Cesium Carbonate. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Scalable and efficient coding of 3D model extracted from a video (2004)

This work presents an efficient and scalable coding scheme for transmitting a stream of 3D models extracted from a video. As in classical model-based video coding, the geometry, connectivity, and texture of the 3D models have to be transmitted, as well as the camera position for each frame in the original video. The proposed method is based on exploiting the interrelations existing between each type of information, instead of coding them independently, allowing a better prediction of the next 3D model in the stream. Scalability is achieved through the use of wavelet-based representations for both texture and geometry of the models. A consistent connectivity is built for all 3D models extracted from the video sequence, which allows a more compact representation and straightforward geometric morphing between successive models. Furthermore this leads to a consistent wavelet decomposition for 3D models in the stream. Quantitative and qualitative results for the proposed scheme are compared with the state of the art video coder H264, 3D model-based Galpin coder and independent MPEG4-based coding of the information. Targeted applications include distant visualization of the original video at very low bit-rate and interactive navigation in the extracted 3D scene on heterogeneous terminals.
Nonuniform Array Design for Robust Millimeter-Wave MIMO Links (2009)

Spatial multiplexing for millimeter (mm) wave line of sight (LOS) links potentially enables data rates of the order of 10-100 Gbps. Most prior work in this area has focused on uniform transmit and receive arrays, for which it is known that the spatial responses seen by different transmitters can be made orthogonal by choosing the antenna spacing appropriately as a function of range and wavelength. In this paper, we show that variations in range can cause significant degradation in performance for such uniformly spaced arrays optimized for a given range, due to the appearance of high correlations between the spatial responses for different transmitters (and hence rank deficiency in the MIMO channel matrix) as a function of range. We then demonstrate that optimized nonuniform arrays alleviate this problem by keeping correlations between spatial responses small over a significantly larger set of ranges than is possible with uniform spacing.
Two-Dimensional Analytical Airgap Field Model of an Inset Permanent Magnet Synchronous Machine, Taking Into Account the Slotting Effect (2012)

In this paper, an analytical method for the computation of the electromagnetic field in the airgap of an inset permanent magnet synchronous machine is proposed. The originality lies in the fact that both the stator and rotor saliencies have been taken into account in the analytical procedure. The purpose in to compute both quickly and accurately the magnetic fluxes and instantaneous torque of the machine, in order to minimize torque ripples in an optimal predesign process. It is shown that the instantaneous torque is in good agreement with finite element results, for a shorter computation time. The model presented here can be used when the 2-D approximation of the machine is valid, which is the case for most of machines' topologies.
A comprehensive profiling of the immune microenvironment of breast cancer brain metastases (2022)

Our results highlight subtype-related differences in BCBM immune microenvironment and identify two potential therapeutic targets, M2 microglia/macrophage polarization in HER2- and PD-1/PD-L1 interaction in HER2+ BCBMs, which warrant future exploration in clinical trials.
A curvable silicon retinal implant (2009)

We have developed a curvable photovoltaic monolithic retinal implant that requires no electrical power or data connection. The implant consists of a two-dimensional network of miniature silicon solar cells that directly stimulate the retina when illuminated by a goggle system. A MEMS process isolates adjacent pixels and makes the arrays curvable allowing them to conform to the shape of the retina.
Infrared Transparent Germanate Glass‐Ceramics (2002)

A new germanate glass‐ceramic material in the BaO‐Ga 2 O 3 ‐GeO 2 system is developed for infrared (IR) dome and window applications. This glass‐ceramic material has a grain size of ∼0.2–0.5 μm and is transparent in the 3–5 μm IR region. Glass ceramization results in 40% improvement in hardness, 65% increase in elastic modulus, 116% increase in strength, and 134% increase in fracture toughness over the base glass.
Characterizations of Plasticized Polymeric Film Coatings for Preparing Multiple-Unit Floating Drug Delivery Systems (muFDDSs) with Controlled-Release Characteristics (2014)

Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic (Eudragit RS, RL, and NE) and cellulosic materials (ethyl cellulose (EC), and Surelease) were examined by a dynamic mechanical analyzer. Results demonstrated that polymeric films prepared from Surelease and EC were brittle with less elongation compared to acrylic films. Eudragit NE films were very flexible in both the dry and wet states. Because plasticizer leached from polymeric films during exposure to the aqueous medium, plasticization of wet Eudragit RS and RL films with 15% triethyl citrate (TEC) or diethyl phthalate (DEP) resulted in less elongation. DEP might be the plasticizer of choice among the plasticizers examined in this study for Eudragit RL to provide muFDDSs with a short time for all pellets to float (TPF) and a longer period of floating. Eudragit RL and RS at a 1∶1 ratio plasticized with 15% DEP were optimally selected as the coating membrane for the floating system. Although the release of losartan from the pellets was still too fast as a result of losartan being freely soluble in water, muFDDSs coated with Eudragit RL and RS at a 1∶1 ratio might have potential use for the sustained release of water-insoluble or the un-ionized form of drugs from gastroretentive drug delivery systems.
Efficient ray sorting for the tracing of incoherent rays (2012)

High-quality rendering via ray tracing requires the tracing of many incoherent secondary rays. In order to accelerate the tracing of incoherent rays, we propose a simple sorting method to increase ray coherence. In this method, we use ray origin buckets and ray direction grids to reorder rays quickly. We implemented our approach on the Manta interactive ray tracer and achieved up to a 1.48× speedup.
61.4: Anthanthrene Derivatives for Stable Blue‐Emitting Organic Electroluminescent Devices (2005)

Abstract Anthanthrene derivatives have been synthesized as a new class of organic light emitting diode (OLED) blue emitters with a wide range of emission. The photo physical properties of the new emitter are reported. The EL device containing these new emitter produced EL efficiency of 3.0cd/A with CIE coordinates of 0.13 and 0.25. The luminance half life is more than 3500 hours with an initial luminance around 600 cd/m 2 .
Laser Heterodyne Radiometry for Remote Sensing of Atmospheric Gases (2019)

A passive remote sensor for full atmospheric columns of O2, CO2 and CH4 has been developed that is based on laser heterodyne radiometry, (LHR), using telecommunications-style diode lasers operating at wavelengths between 1278 and 1650 nm as local oscillators. Spectral resolution is 0.0067 cm-1 and will soon be improved two-fold. Retrievals require including line narrow effects, particularly for O2.
A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy (2017)

Despite vigorous ART regimens, HIV-1 DNA and RNA were easily detected in mature macrophages supporting their potential role as an infectious viral reservoir.
ChemInform Abstract: Enantioselective Staudinger Synthesis of β‐Lactams Catalyzed by a Planar‐Chiral Nucleophile. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Self-sustaining smouldering combustion for the treatment of industrial oily waste (2022)

Significant onsite handling and offsite management costs are incurred by oilfield operators annually to properly manage hydrocarbon waste streams such as tank bottoms or other oily sludge or oil impacted soil generated during oil and gas production processes. The current study reports for the first-time technical results of a field trial on use of a smouldering combustion technology performed in an active oilfield. Two treatment batches with oily sludges, stabilized through blending with soil, resulted in permanent hydrocarbon removal (98-99.9% reduction) to create treated soil that met standards for reuse as clean backfill onsite. Emissions profile data collected pre- and post-thermal oxidizer indicated effective removal of volatile organic compounds, CO and SO<sub>2</sub>, but had increased NO and CO<sub>2</sub> due to combustion of propane to affect the thermal oxidation. Regulatory, financial, environmental and safety considerations are discussed in context of future full-scale smouldering technology deployment. The technology has the potential to lower overall unit costs for management of hydrocarbon impacted waste and reduce waste sent to landfills, which can benefit more remote sites.
Correlation between Ligand−Receptor Affinity and the Transcription Readout in a Yeast Three-Hybrid System (2004)

The yeast two-hybrid assay has proven to be a powerful method to detect protein-protein interactions as well as to derive genome-wide protein interaction maps. More recently, three-hybrid assays have emerged as a means to detect both protein-RNA and protein-small molecule interactions. Despite the routine use of the two-hybrid assay and the potential of three-hybrid systems, there has been little quantitative characterization to understand how the strength of the protein interaction correlates with transcription activation. It is not known if the additional interaction in three-hybrid systems compromises the sensitivity of the system. Thus, here, we set out to determine the K(D) cutoff of a small molecule three-hybrid system and to determine if there is a correlation between the K(D) and the levels of transcription activation. A series of mutations to FK506-binding protein 12 (FKBP12) were designed to vary the affinity of this protein for the small molecule synthetic ligand for FK506-binding protein 12 (SLF). These FKBP12 variants were overexpressed and purified, and their K(D)'s for SLF were measured using a fluorescence polarization assay. Then the levels of transcription activation in a Mtx-DHFR yeast three-hybrid system were determined for these variants using a lacZ reporter gene. The K(D) cutoff of the Mtx yeast three-hybrid system is found to be ca. 50 nM. Further, the levels of transcription activation correlate with the strength of the binding interaction, though the dynamic range is only 1 order of magnitude. These results establish that the three-hybrid assay has the requisite sensitivity for drug discovery. However, the small dynamic range highlights a limitation to equilibrium-based assays for discriminating interactions based on affinity.