gebhart/patrepeval huggingface dataset:
Analysis of checkpointing schemes with task duplication (1998)

The paper suggests a technique for analyzing the performance of checkpointing schemes with task duplication. We show how this technique can be used to derive the average execution time of a task and other important parameters related to the performance of checkpointing schemes. The analysis results are used to study and compare the performance of four existing checkpointing schemes. Our comparison results show that, in general, the number of processors used, not the complexity of the scheme, has the most effect on the scheme performance.
Ultrasensitive fluorescence detection of DNA. Progress report, August 1, 1990--December 1, 1991 (1991)

Progress on Ultrasensitive fluorescence detection of DNA is briefly described. (CBS)
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants (2018)

A series of linear HCV NS3/4A protease inhibitors was designed by eliminating the P2-P4 macrocyclic linker in grazoprevir, which, in addition to conferring conformational flexibility, allowed structure-activity relationship (SAR) exploration of diverse quinoxalines at the P2 position. Biochemical and replicon data indicated preference for small hydrophobic groups at the 3-position of P2 quinoxaline for maintaining potency against resistant variants R155K, A156T, and D168A/V. The linear inhibitors, though generally less potent than the corresponding macrocyclic analogues, were relatively easier to synthesize and less susceptible to drug resistance. Three inhibitor cocrystal structures bound to wild-type NS3/4A protease revealed a conformation with subtle changes in the binding of P2 quinoxaline, depending on the 3-position substituent, likely impacting both inhibitor potency and resistance profile. The SAR and structural analysis highlight inhibitor features that strengthen interactions of the P2 moiety with the catalytic triad residues, providing valuable insights to improve potency against resistant variants.
Near-Infrared Analysis of Ground Barley for Use as a Feedstock for Fuel Ethanol Production (2007)

The objective of this study was to explore the potential of near-infrared spectroscopy for determining the compositional quality properties of barley as a feedstock for fuel ethanol production and to compare the prediction accuracy between calibration models obtained using a Fourier transform near-infrared system (FT-NIR) and a dispersive near-infrared system. The total sample set contained 206 samples of three types of barley, hull-less, malt, and hulled varieties, which were grown at various locations in the eastern U.S. from 2002 to 2005 years. A new hull-less barley variety, Doyce, which was specially bred for potential use in ethanol production, was included in the sample set. One hundred and thirty-eight barley samples were used for calibration and sixty-eight were used for validation. Ground barley samples were scanned on both a FTNIR spectrometer (10 000 to 4000 cm(-1) at 4 cm(-1) resolution) and a dispersive NIR spectrometer (400 to 2498 nm at 10 nm resolution), respectively. Six grain components, moisture, starch, beta-glucan, protein, oil, and ash content, were analyzed as parameters of barley quality. Principal component analysis showed that barley samples could be classified by their types: hull-less, malt, and hulled. Partial least squares regression indicated that both FT-NIR and dispersive NIR spectroscopy have the potential to determine quality properties of barley with an acceptable accuracy, except for beta-glucan content. There was no predictive advantage in using a high-resolution FT-NIR instrument over a dispersive system for most components of barley.
WE-G-18A-02: Calibration-Free Combined KV/MV Short Scan CBCT (2014)

Purpose: To combine orthogonal kilo-voltage (kV) and Mega-voltage (MV) projection data for short scan cone-beam CT to reduce imaging time on current radiation treatment systems, using a calibration-free gain correction method. Methods: Combining two orthogonal projection data sets for kV and MV imaging hardware can reduce the scan angle to as small as 110° (90°+fan) such that the total scan time is ∼18 seconds, or within a breath hold. To obtain an accurate reconstruction, the MV projection data is first linearly corrected using linear regression using the redundant data from the start and end of the sinogram, and then the combined data is reconstructed using the FDK method. To correct for the different changes of attenuation coefficients in kV/MV between soft tissue and bone, the forward projection of the segmented bone and soft tissue from the first reconstruction in the redundant region are added to the linear regression model. The MV data is corrected again using the additional information from the segmented image, and combined with kV for a second FDK reconstruction. We simulated polychromatic 120 kVp (conventional a-Si EPID with CsI) and 2.5 MVp (prototype high-DQE MV detector) projection data with Poisson noise using the XCAT phantom. The gain correction and combined kV/MV short scan reconstructions were tested with head and thorax cases, and simple contrast-to-noise ratio measurements were made in a low-contrast pattern in the head. Results: The FDK reconstruction using the proposed gain correction method can effectively reduce artifacts caused by the differences of attenuation coefficients in the kV/MV data. The CNRs of the short scans for kV, MV, and kV/MV are 5.0, 2.6 and 3.4 respectively. The proposed gain correction method also works with truncated projections. Conclusion: A novel gain correction and reconstruction method was developed to generate short scan CBCT from orthogonal kV/MV projections. This work is supported by NIH Grant 5R01CA138426-05.
Optofluidic Electrical Manipulation of Individual Biomolecules with nm-scale Precision (2013)

We design and demonstrate electrically controlled optical trapping of individual microparticles and manipulation of biomolecules with nm-scale precision for high throughput applications. This has been realized by integration of photonics, fluidics, and electronics, on-chip.
Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands (2020)

Accurate in silico models for the quantitative prediction of the activity of G protein-coupled receptor (GPCR) ligands would greatly facilitate the process of drug discovery and development. Several methodologies have been developed based on the properties of the ligands, the direct study of the receptor-ligand interactions, or a combination of both approaches. Ligand-based three-dimensional quantitative structure-activity relationships (3D-QSAR) techniques, not requiring knowledge of the receptor structure, have been historically the first to be applied to the prediction of the activity of GPCR ligands. They are generally endowed with robustness and good ranking ability; however they are highly dependent on training sets. Structure-based techniques generally do not provide the level of accuracy necessary to yield meaningful rankings when applied to GPCR homology models. However, they are essentially independent from training sets and have a sufficient level of accuracy to allow an effective discrimination between binders and nonbinders, thus qualifying as viable lead discovery tools. The combination of ligand and structure-based methodologies in the form of receptor-based 3D-QSAR and ligand and structure-based consensus models results in robust and accurate quantitative predictions. The contribution of the structure-based component to these combined approaches is expected to become more substantial and effective in the future, as more sophisticated scoring functions are developed and more detailed structural information on GPCRs is gathered.
Modeling the performance of limited pointers directories for cache coherence (1991)

protocols have been proposed as an efficient means of implementing cache consistency in large-scale shamxlmemory multiprocessors.
Modulated natural inflation (2015)

We discuss some model-independent implications of embedding (aligned) axionic inflation in string theory. As a consequence of string theoretic duality symmetries the pure cosine potentials of natural inflation are replaced by modular functions. This leads to "wiggles" in the inflationary potential that modify the predictions with respect to CMB-observations. In particular, the scalar power spectrum deviates from the standard power law form. As a by-product one can show that trans-Planckian excursions of the aligned effective axion are compatible with the weak gravity conjecture.
Reversible Graphite Anode Cycling with PC-Based Electrolytes Enabled by Added Sulfur Trioxide Complexes (2017)

Pyridine sulfur trioxide (PyrSO3), trimethyl amine sulfur trioxide (Me3NSO3), and triethyl amine sulfur trioxide (Et3NSO3) complexes have been investigated as electrolyte additives for lithium ion batteries. Incorporation of 0.5 to 2.0% of the SO3 complexes into a PC/EMC (1:1 v/v) 1 M LiPF6 baseline electrolyte affords reversible cycling of graphite anodes confirming generation of a stable Solid Electrolyte Interphase (SEI). Good cycling performance is observed for graphite/LiNi0.5Mn1.5O4 cells cycled to high potential (4.8 V vs Li) containing PC based electrolyte with added SO3 complexes. Ex-situ surface analysis via X-ray Photoelectron Spectroscopy (XPS) of the anodes reveals SO3 complex reduction on the surface of the graphite anode generates a sulfur-based SEI containing sulfites, sulfide, and sulfate species. The presence of the sulfur containing species is likely critical for the stability of the SEI. Ex-situ XPS analyses of the LiNi0.5Mn1.5O4 cathodes suggest that reaction of Me3NSO3 or Et3NSO3 complexes at high potential result in the generation of a stable passivation layer which affords good capacity retention and coulombic efficiency.
Using admissions criteria for predicting student failure outcomes of supplemental instruction and remediation in a Doctor of Pharmacy programme (2017)

Objective: To identify potential unique predictors of academic failure or success in a Doctor of Pharmacy programme  using curricular experiences with supplemental instruction (SI) and remediation. Methods: We assessed correlations between admissions variables, including grade point average (GPA) and Pharmacy College Admissions Test (PCAT) scores, with curricular performance measures, including SI and remediation, in 369 students over four years. Results: Overall entry GPA, pre-requisite/pre-pharmacy GPA, and required maths and science GPA negatively correlated with number of SI enrolments and remediation. Lower PCAT verbal and quantitative ability scores negatively correlated with number of remediation sessions while lower PCAT chemistry and reading comprehension scores negatively correlated with number of SI enrolments and course failures. Overall entry, pre-requisite/pre-pharmacy, and required maths and science GPA; and PCAT composite, quantitative ability, and chemistry scores positively correlated with GPA after the first academic year and at graduation. Conclusions: Students with higher GPAs and PCAT scores were less likely to need academic support. Lower GPAs and PCAT scores correlated to an increased likelihood of failure and predict need for academic assistance to ensure success.
Parallel Simulation of Superscalar Scheduling (2014)

Computers have been moving toward a multicore paradigm for the last several years. As a result of the recent multicore paradigm shift, software developers must design applications that exploit the inherent parallelism of modern computing architectures. One of the areas of research to simplify this shift is the development of dynamic scheduling utilities that allow the developer to specify serial code that can be parallelized using a library or compiler technology. While these tools certainly increase the developer's productivity, they can obfuscate performance bottlenecks. For this reason, it is important to evaluate algorithm performance in order to ensure that the performance of a given algorithm is being realized using dynamic scheduling utilities. This paper presents the methodology and results of a new performance analysis tool that aims to accurately simulate the performance of various superscalar schedulers, including OmpSs, StarPU, and QUARK. The process begins with careful timing of each of the computational routines that make up the algorithm. The simulation tool then uses the timing of the computational kernels in conjunction with the dependency management provided by the superscalar scheduler in order to simulate the execution time of the algorithm. This tool demonstrates that simulation results of various algorithms can accurately predict the performance of a complex dynamic scheduling system.
Prozesse und Threads (1995)

Betriebssysteme, die parallele Programme ermöglichen, erfordern besondere Strukturen zur Prozeßverwaltung. Im Kern ist ein Mechanismus zur Zuteilung und Entziehung der CPU notwendig, um mehrere Tasks im Wechsel auszuführen. Daneben ist eine Strategie zur Auswahl des Programmes, das als nächstes ausgeführt wird, unentbehrlich. Der Algorithmus soll verschiedene Anforderungen, wie deterministische Reaktionszeiten oder maximale Gerechtigkeit, erfüllen. In diesem Kapitel wird die Programmverwaltung im Detail untersucht; ferner entwickeln wir mehrere Realisierungen zur Prozeßauswahl mit unterschiedlichen Leistungsmerkmalen.
Nanoporous Piezo- and Ferroelectric Thin Films (2011)

Nanoporous barium titanate and lead titanate thin films (∼100 nm calculated from ellipsometric data) are prepared starting from sol-gel solutions modified with a commercially available block-copolymer and evaporation-induced self-assembly methodology. The tuning of the thermal treatment followed by in situ ellipsometry allows the decomposition of the organic components and of the structuring agent leading to the formation of porous tetragonal crystalline perovskite structures as observed by XRD, HRTEM, SEM, and ellipsoporosimetry. Both nanoporous barium titanate and lead titanate thin films present local piezoelectric and ferroelectric behavior measured by piezoresponse force microscopy (PFM), being promising platforms for the preparation of the generation of new multifunctional systems.
Resource Control for Database Extensions (1998)

While object-relational database servers can be extended with user-defined functions (UDFs), the security of the server may be compromised by these extensions. The use of Java to implement the UDFs is promising because it addresses some security concerns. However, it still permits interference between different users through the uncontrolled consumption of resources. In this paper, we explore the use of a Java resource management mechanism (JRes) to monitor resource consumption and enforce usage constraints. JRes enhances the security of the server in the presence of extensions allowing for (i) detection and neutralization of denial-of-service attacks aimed at resource monopolization, (ii) monitoring resource consumption which enables precise billing of users relying on UDFs, and (iii) obtaining feedback that can be used for adaptive query optimization. The feedback can be utilized either by the UDFs themselves or by the database system to dynamically modify the query execution plan. Both models have been prototyped in the Cornell Predator database system. We describe the implementation techniques, and present experiments that demonstrate the effects of the adaptive behavior facilitated by JRes. We conclude that, minimally, a database system supporting extensions should have a built-in resource monitoring and controlling mechanism. Moreover, in order to fully exploit information provided by the resource control mechanisms, both the query optimizer and the UDFs themselves should have access to this information. 1
A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo (2015)

SCOPUS: ar.j
Strategy for repeat procedures in patients with persistent atrial fibrillation: Systematic linear ablation with adjunctive ethanol infusion into the vein of Marshall versus electrophysiology‐guided ablation (2022)

Anatomically guided strategy with adjunctive Et-VOM is superior to an electrophysiology-guided strategy for second procedures in patients with perAF at 1-year follow-up.
Deposition of metal nanostructures onto Si(111) surfaces by field evaporation in the scanning tunneling microscope (1994)

Islands of gold or copper having dimensions as small as 200 Å in diameter and 10 Å in height were prepared by field evaporation from a tip of the appropriate metal in a scanning tunneling microscope (STM). The field emission of metal is induced by the application of tip-negative bias pulses having amplitudes of 6–20 V, and durations of 2 μs to 2 ms. The metallic composition of the protrusions observed by STM are confirmed by ex situ elemental analysis using the field emission scanning Auger microprobe (FE-SAM). Tip-positive bias pulses also produce protrusions, however these are unstable either to STM imaging or to exposure to high-energy electron beams, as in the FE-SAM instrument. It is therefore probable that nonostructures formed via tip-positive bias pulses are not metallic. These data provide the first direct experimental evidence for metal transfer between an STM tip and a surface.
Controlled-Release Morphine Bioavailability (MS Contin® Tablets) in the Presence and Absence of Food (1990)

The bioavailability of a single, orally administered, 30-mg controlled-release morphine tablet (MS Contin Tablet; The Purdue Frederick Company, Norwalk, Conn.) was compared after fasting or a high fat meal in this single dose, randomized, crossover study involving 24 healthy male subjects. There was no significant (p greater than 0.05) difference in the mean extent of morphine absorption over 24 hours in the presence or absence of food (area under the plasma concentration vs. time curve [AUC(0,24)], fed = 107% of fasted). Time to maximal concentration (Tmax) was similar (p greater than 0.05) in the two treatment groups; the mean Tmax for fed volunteers was 2.5 hours versus 2.4 hours for fasted volunteers. The two regimens did not differ significantly (p greater than 0.05) with regard to maximal morphine concentration (Cmax); mean Cmax for fed subjects was 8.22 ng/ml whereas mean Cmax for fasted subjects was 8.53 ng/ It was concluded that consumption of a high fat meal did not affect either the rate or extent of morphine absorption, or any of the other pharmacokinetic parameters tested, following administration of MSC.
Graded-phase mirror resonators (1994)

Optical resonators designed for low- to medium-gain lasers generally consist of "stable" cavities using spherical mirrors. The nearly ideal Gaussian fundamental mode profile of such resonators is advantageous in terms of beam quality and reduced diffraction losses. However, for laser applications requiring single transverse mode operation, the stable geometry presents a serious drawback in terms of energy efficiency. The small beamwaist of the confined fundamental mode exploits only a reduced fraction of the available gain section and the poor modal selectivity limits the degree of saturation that can be reached in the single mode regime. The idea of using aspherical mirrors (graded-phase mirrors GPMs) has been proposed in the early days of laser development. The objective was to increase the effective mode cross section by improving the uniformity of the fundamental mode. However, in absence of guidelines, those studies were made on a trial-and-error basis and the conclusions were far from exhaustive. The interest for aspherical mirrors was also refrained by limitations in technology.
Multi-media compliance: A practical paradigm for managing business integrity (2009)

In virtually every business context there is a need to establish some form of monitoring system to ensure that employees comply with business processes and policies. Compliance failures range from organized theft to gaps in procedure that can be easily remedied through retraining. It is clearly important for businesses to capture and record these deviations to minimize loss prevention and maximize workplace safety and efficiency. In this workshop, we discuss the growing problem of compliance failure and how our system addresses this problem in a retail context to detect checkout-related fraud through the integration of visual and non-visual data.
Formation of a Stable Rhodium(I) Dihydride Complex and Its Reactions with Prochiral Substrates of Asymmetric Hydrogenation (2001)

A new P-chirogenic diphosphine, (S,S)-α,α‘-bis(tert-butylmethylphosphino)-o-xylene (1), was synthesized in two steps from optically active secondary phosphine-borane 4 via the corresponding diphosphine-borane 3. The Rh(I) complex (2) of 1 was characterized by X-ray study, which revealed a significantly distorted C2-symmetry. The catalytic hydrogenation of four representative prochiral substrates gave modest enantioselection. Unlike all previously studied Rh(I) complexes of chiral diphosphines, 2 reacts with dihydrogen at −70 °C, producing two diastereomers of a solvate dihydride, 5a,b, in a ratio 1:0.07. The formation of 5a,b is almost quantitative; the hydrogen is not eliminated from 5. At temperatures above 20 °C, further transformation of 5 takes place, eventually yielding a bridging binuclear complex 6. The reaction of 5 with methyl Z-(α)-acetamidocinnamate (7) is slow at −80 °C, and gradual accumulation of a mixture of monohydride intermediates 15a−d could be monitored by 1H NMR spectroscopy. When 5 was reacted with dimethyl 1-benzoyloxyethenephosphonate (10), two monohydride intermediates, 19a,b, formed cleanly in a ratio 1:0.04, which corresponded to the 92% ee observed after reductive elimination and quenching the reaction mixture.
Multisite MRI reproducibility of lateral ventricular volume using the NAIMS cooperative pilot dataset (2022)

Fully automated LVV segmentation has higher absolute variability than WBV, but much lower relative variability compared to clinically relevant changes, and may therefore be a meaningful proxy outcome measure of neurodegeneration.