gebhart/patrepeval huggingface dataset:
Rapid Induction of Multiple Taxonomies for Enhanced Faceted Text Browsing (2016)

In this paper we present and compare two methodologies for rapidly inducing multiple subject-specific taxonomies from crawled data. The first method involves a sentence-level words co-occurrence frequency method for building the taxonomy, while the second involves the bootstrapping of a Word2Vec based algorithm with a directed crawler. We exploit the multilingual open-content directory of the World Wide Web, DMOZ 1 to seed the crawl, and the domain name to direct the crawl. This domain corpus is then input to our algorithm that can automatically induce taxonomies. The induced taxonomies provide hierarchical semantic dimensions for the purposes of faceted browsing. As part of an ongoing personal semantics project, we applied the resulting taxonomies to personal social media data (Twitter, Gmail, Facebook, Instagram, Flickr) with an objective of enhancing an individual's exploration of their personal information through faceted searching. We also perform a comprehensive corpus based evaluation of the algorithms based on many datasets drawn from the fields of medicine (diseases) and leisure (hobbies) and show that the induced taxonomies are of high quality.
NOISE IN DIGITAL SYSTEMS (1998)

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Reduction of the hydrogen degradation in SrBi2(Ta1−xNbx)2O9 by TiN barrier metal (2000)

The use of ferroelectric SrBi2(Ta1−xNbx)2O9 (SBTN) as a mainstream form of nonvolatile memory requires that the degradation of its electrical qualities that is caused by annealing in a hydrogen atmosphere be reduced. Titanium nitride (TiN) is a candidate for use as a barrier-metal layer against hydrogen diffusion. The relationship between the degradation in the qualities of SBTN and the quality of the TiN barrier metal has been investigated. TiN when sputtered onto SBTN capacitors creates a good barrier under all sputtering conditions, and maintains the electrical characteristics of the SBTN through annealing in an atmosphere of H2. Higher density TiN films provide more effective protection. The characteristics of the degraded capacitor were investigated in terms of its current-voltage characteristic. Remanent polarization can be recovered from, at least partially, by applying a series of bipolar pulses. This rejuvenation of the electrical qualities indicates that degradation arises from a combination of electrical and structural faults.
Squamous Cell Carcinoma of the Prostate: 2 Cases of a Rare Malignancy and Review of the Literature (1993)

Primary squamous cell carcinoma of the prostate is an extremely uncommon malignancy, accounting for less than 1% of all prostatic cancers. We report on 2 patients with primary squamous cell carcinoma of the prostate: 1 with organ-confined disease and 1 with metastatic disease. Both patients presented with urinary obstructive symptoms and carcinoma was not suspected on digital rectal examination. Serum acid phosphatase and prostate specific antigen levels were normal. From a review of the literature and our 2 cases it is apparent that squamous cell carcinoma of the prostate is biologically more aggressive than adenocarcinoma.
Transport and Electron Transfer Dynamics in a Polyether-Tailed Cobalt Bipyridine Molten Salt:  Electrolyte Effects (1997)

Transport, ionic conductivity, and viscosity properties of the metal complex molten salt [Co(bpy(CO2MePEG-350)2)3](ClO4)2 (MePEG = monomethyl-terminated polyether, average MW = 350) are strongly affected by dissolution of LiClO4 electrolyte in the melt. The physical self-diffusion of the [Co(bpy(CO2MePEG-350)2)3]2+ and the rate of [Co(bpy(CO2MePEG-350)2)3]2+/+ electron self-exchange are slowed, the melt viscosity increased and ionic conductivity decreased, and thermal activation barriers for all are enhanced by increasing [LiClO4]. Most of the effects are associated with the Li+ cation/polyether coordination well-known in polymer electrolytes, in which chain cross-linking and a decrease in chain segmental mobility occurs. The [Co(bpy(CO2MePEG-350)2)3]2+/+ electron self-exchange reaction is shown to be adiabatic (kinetic prefactor ca. 1013 s-1), and modest changes in its rate with [LiClO4] are caused by changes in the electron transfer barrier energy. The results are used to draw a hierarchy of dynamics in the metal complex melt in which, for [LiClO4] = 1.3 M, the average diffusive jump rate is ca. 3 s-1, the average electron hopping rate is ca. 2 × 104 s-1, and the rate of short-range motions of the hard metal complex core within its soft polyether shell (producing adjacent core−core contacts) is ca. ≥ 105 s-1.
P‐192: Development of New Linker Moiety for TADF Materials: Elucidation of Material Properties by Substitution Position Effect (2019)

Two thermally activated delayed fluorescent(TADF) materials, 23TrzCz and 32TrzCz, were successfully designed and synthesized using an aromatic linker moiety for green organic light emitting diodes(OLEDs). The donor moiety was 3,3‐bicarbazole and the acceptor moiety was diphenyltriazine. The synthesized materials were used as an emitter in OLED device and the 23TrzCz showed highly efficient device performance with a power efficiency of 31.0 lm/W and an external quantum efficiency of 18.3%. In addition, the 23TrzCz showed emission of CIE x,y (0.30, 0.56) suitable for green devices.
Invited Talk 3 (2019)

Provides an abstract of the invited presentation and may include a brief professional biography of the presenter. The complete presentation was not made available for publication as part of the conference proceedings.
High-Throughput Screening of Encapsulated Islets Using Wide-Field Lens-Free On-Chip Imaging (2018)

Islet microencapsulation is a promising solution to diabetes treatment, but its quality control based on manual microscopic inspection is extremely low-throughput, highly variable, and laborious. This study presents a high-throughput islet-encapsulation quality screening system based on lens-free on-chip imaging with a wide field-of-view of 18.15 cm2, which is more than 100× larger than that of a lens-based optical microscope, enabling it to image and analyze ∼8000 microcapsules in a single frame. Custom-written image reconstruction and processing software provides the user with clinically important information, such as microcapsule count, size, intactness, and information on whether each capsule contains an islet. This high-throughput and cost-effective platform can be useful for researchers to develop better encapsulation protocols as well as perform quality control prior to transplantation.
Tertiäres Phosphan/Hexachlorethan als Kondensationsreagenz für die Peptidsynthese: Die Synthese von Bradykinin (1979)

Tertiary Phosphane Hexachloroethane as Condensing Agent in Peptide Synthesis: The Synthesis of Bradykinin In order to evaluate the usefulness of the tris(dimethylamino)phosphane/hexachloroethane/1‐hydroxybenzotriazole method in peptide synthesis, the nonapeptide bradykinin was synthesized.
In-situ Growth of Platinum with Hierarchical Porosity for Low Impedance Biomedical Microelectrode Fabrication (2016)

We report a novel process that allows depositing hierarchically porous platinum, i.e. platinum with structured pores from about 1 micron down to 3 nm in porosity, in situ on flexible microelectrodes. The process is based on molecular self-assembly of a porous silica zeotile, which is then deposited on the electrode contacts of flexible platinum electrode arrays fabricated with classic lithographic techniques. The pores are then Pt filled using atomic layer deposition (ALD) and the silica mold is removed chemically. Compared to our earlier work, the in-situ ALD step improves adhesion and allows a lower temperature budget as no sintering is required. An up to 1000x reduction in electrode impedance was measured as well as a 12x increase in charge injection capacity.
Deep Learning Based Kalman Filter for Variable-Frequency Disturbance Elimination in Force Sensing (2021)

This paper proposes a new approach for force sensation with the elimination of variable-frequency disturbances using deep learning based Kalman filter. The disturbance observer is employed for force estimation. To cancel the effect of undesired variable-frequency components superimposed in force information, the deep learning based Kalman filter is designed as an integration of the deep learning based frequency estimation and the periodic component elimination Kalman filter. The Kalman filter is designed to eliminate the periodic component by estimating the signal with periodic component, the first derivative and the second derivative of that signal. The deep learning based frequency estimation is constructed by the long short-term memory deep neural network to estimate the frequency of the periodic disturbance during force sensing operation. Hence, the frequency variation of the periodic component is detectable. This estimated frequency is a parameter which determines the performance of the Kalman filter in periodic component elimination. Therefore, the deep learning based Kalman filter is capable of excluding the undesired components with variable frequencies. The effectiveness of the proposed method is verified by numerical simulation results.
Reconstruction and Functional Characterization of the Human Mitochondrial Metabolic Network Based on Proteomic and (2004)

Diverse datasets including genomic, proteomic, isotopomer, and DNA sequence variation are becoming available for human mitochondria. Thus there is a need to integrate these data within an in silico modeling framework where mitochondrial biology and related disorders can be studied and analyzed. This paper reports a reconstruction and characterization of the human mitochondrial metabolic network based on proteomic and biochemical data. The 189 reactions included in this reconstruction are both elementally and charge-balanced and are assigned to their respective cellular compartments (mitochondrial, cytosol, or extracellular). The capabilities of the reconstructed network to fulfill three metabolic functions (ATP production, heme synthesis, and mixed phospholipid synthesis) were determined. Network-based analysis of the mitochondrial energy conversion process showed that the overall ATP yield per glucose is 31.5. Network flexibility, characterized by allowable variation in reaction fluxes, was evaluated using flux variability analysis and analysis of all of the possible optimal flux distributions. Results showed that the network has high flexibility for the biosynthesis of heme and phospholipids but modest flexibility for maximal ATP production. A subset of all of the optimal network flux distributions, computed with respect to the three metabolic functions individually, was found to be highly correlated, suggesting that this set may contain physiological meaningful fluxes. Examinations of optimal flux distributions also identified correlated reaction sets that form functional modules in the network.
Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities (2022)

This study reveals that computationally-derived features from the spatial architecture of TILs and tumor cells are prognostic in GCs treated with chemotherapy, radiotherapy, and checkpoint blockade and are closely associated with central biological processes that impact tumor progression. These findings could aid in identifying therapy-refractory patients and further enable personalized treatment decision-making.
Paper Based, Expanded Graphite/Polypyrrole Nanocomposite Supercapacitors Free from Binders and Current Collectors (2018)

Expanded graphite (EG) - polypyrrole (PPy) hybrid nanocomposites are used for the fabrication of paper-based highly flexible supercapacitor devices. Brush-painted EG electrodes are utilized as electrodes for the electrodeposition of PPy, resulting in the formation of nanocomposite electrodes with the desired material loading. Fabricated paper-based electrodes are free from heavy current collectors, binders, and conductive additives. Within nanocomposite electrodes, expanded graphite layer on paper facilitates the charge transfer and conformal PPy layer atop improves capacitance through pseudocapacitance. Fabricated nanocomposite electrodes are highly flexible, thanks to excellent mechanical integrity among paper, EG and PPy components. A specific capacitance of 177.8 F g(-1), in conjunction with a capacity retention of more than 94.9% is obtained following 5000 cycles. With the simple fabrication and promising electrochemical performance obtained herein, fabricated paper-based nanocomposite supercapacitors are envisaged for utilization as power sources in paper electronics. (C) 2018 The Electrochemical Society.
Overlay improvements using a real time machine learning algorithm (2014)

While semiconductor manufacturing is moving towards the 14nm node using immersion lithography, the overlay requirements are tightened to below 5nm. Next to improvements in the immersion scanner platform, enhancements in the overlay optimization and process control are needed to enable these low overlay numbers. Whereas conventional overlay control methods address wafer and lot variation autonomously with wafer pre exposure alignment metrology and post exposure overlay metrology, we see a need to reduce these variations by correlating more of the TWINSCAN system’s sensor data directly to the post exposure YieldStar metrology in time. In this paper we will present the results of a study on applying a real time control algorithm based on machine learning technology. Machine learning methods use context and TWINSCAN system sensor data paired with post exposure YieldStar metrology to recognize generic behavior and train the control system to anticipate on this generic behavior. Specific for this study, the data concerns immersion scanner context, sensor data and on-wafer measured overlay data. By making the link between the scanner data and the wafer data we are able to establish a real time relationship. The result is an inline controller that accounts for small changes in scanner hardware performance in time while picking up subtle lot to lot and wafer to wafer deviations introduced by wafer processing.
Functional Compensation by Egr4 in Egr1-Dependent Luteinizing Hormone Regulation and Leydig Cell Steroidogenesis (2000)

The Egr family of zinc finger transcription factors, whose members are encoded by Egr1 (NGFI-A), Egr2 (Krox20), Egr3, and Egr4 (NGFI-C) regulate critical genetic programs involved in cellular growth, differentiation, and function. Egr1 regulates luteinizing hormone beta subunit (LHbeta) gene expression in the pituitary gland. Due to decreased levels of LHbeta, female Egr1-deficient mice are anovulatory, have low levels of progesterone, and are infertile. By contrast, male mutant mice show no identifiable defects in spermatogenesis, testosterone synthesis, or fertility. Here, we have shown that serum LH levels in male Egr1-deficient mice are adequate for maintenance of Leydig cell steroidogenesis and fertility because of partial functional redundancy with the closely related transcription factor Egr4. Egr4-Egr1 double mutant male mice had low steady-state levels of serum LH, physiologically low serum levels of testosterone, and atrophy of androgen-dependent organs that were not present in either Egr1- or Egr4-deficient males. In double mutant male mice, atrophic androgen-dependent organs and Leydig cell steroidogenesis were fully restored by administration of exogenous testosterone or human chorionic gonadotropin (an LH receptor agonist), respectively. Moreover, a normal distribution of gonadotropin-releasing hormone-containing neurons and normal innervation of the median eminence in the hypothalamus, as well as decreased levels of LH gene expression in Egr4-Egr1-relative to Egr1-deficient male mice, indicates a defect of LH regulation in pituitary gonadotropes. These results elucidate a novel level of redundancy between Egr4 and Egr1 in regulating LH production in male mice.
Magneto-Acoustic Resonator for Aquatic Animal Tracking (2018)

Over the past three decades, passive acoustic telemetry has significantly helped marine scientist to study and understand the spatial ecology, migratory behaviors, and mortality rates of aquatic animals. A popular telemetry system consists of two components: an acoustic transmitter tag attached to an aquatic animal and powered by a small battery, and a stationary station that receives the acoustic signals from the tagged animal and determines its location. The added weight and increased size of the tag introduced by the battery limit the implementation of this system to relatively large animals. Moreover, these tags have a limited operational time determined by the lifetime of the battery in combination with the measurement frequency and data resolution and transfer rate. In this paper, a self-powered magneto-acoustic resonator for animal tracking is proposed. It is achieved by utilizing the low-frequency motions of the animals to excite high-frequency acoustic pulses. The measurement results show that the device is capable of producing an average acoustic sound of 55 dB sound pressure level at 1 m of distance with a resonant frequency of 15 kHz.
Automated localization and quality control of the aorta in cine CMR can significantly accelerate processing of the UK Biobank population data (2019)

The proposed method for automated AA and PDA localization was extremely accurate and the automatically derived detection probabilities provided a robust mechanism to detect low quality scans for further human review. Applying the proposed localization and quality control techniques promises at least a ten-fold reduction in human involvement without sacrificing any accuracy.
Azo-functionalized dendrimers (2004)

We report the synthesis of azo-functionalized Starburst polyamidoamine (PAMAM) dendrimers. The following three systems of azo-functionalized PAMAM dendrimers were prepared by different synthetic routes: (i) phenylazo derivatives; (ii) naphthalimide azo derivatives; and (iii) phthalimide azo derivatives. Model compounds in each system were synthesized for spectroscopic comparison. Confirmation of structure was achieved using a combination of NMR and IR spectroscopy to ascertain the functional sites (i.e., the azo and the cyclic imides), while mass spectrometry and UVvis spectrophotometry were employed to ascertain the extent of functionalization. Substitution by the azo pendent groups increased the thermal stability of PAMAM dendrimers (TGA weight loss of the naphthalimide azo-functionalized PAMAM dendrimers up to 300 °C, ca. 5%).Key words: dendrimers, azo compounds, hydrazones, tautomerism, hydrogen bonding.
Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure (2011)

NIRS can be used to detect changes in StO2 and THI consequent upon central hypovolemia. Forearm NIRS measurements reflect hypovolemia more sensitively than thenar NIRS measurements. The sensitivity of these NIRS measurements does not depend on NIRS probing depth. The LBNP-induced shift in blood volume is reflected by a decreased THI in the forearm and an increased THI in the calf.
Adjunctive inhaled insulin before meals improved glycaemic control more than adjunctive metformin in type 2 diabetes mellitus (2006)

Barnett AH, Dreyer M, Lange P, et al. An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea. Diabetes Care 2006;29:1282–7. [OpenUrl][1][Abstract/FREE Full Text][2] Q In patients with type 2 diabetes mellitus poorly controlled with sulphonylurea monotherapy, is adjunctive inhaled human insulin (INH) better than adjunctive metformin? Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★★ ### ![Graphic][3]</img>Design: randomised controlled trial. ### ![Graphic][4]</img>Allocation: concealed.* ### ![Graphic][5]</img>Blinding: unblinded.* ### ![Graphic][6]</img>Follow up period: 24 weeks. ### ![Graphic][7]</img>Setting: 13 centres in Europe, South Africa, Israel, and Brazil. ### ![Graphic][8]</img>Patients: 427 patients 35–80 years of age (mean age 60 y, 53% men) who had type 2 diabetes mellitus ⩾6 months, were poorly controlled on sulphonylurea therapy ⩾2 months, and had normal pulmonary function test results. Exclusion criteria included asthma or chronic obstructive pulmonary disease; smoking in the previous 6 months; concomitant therapy with hypoglycaemic agents or agents that may affect glycaemic control; fasting C … [1]: {openurl}?query=rft.jtitle%253DDiabetes%2BCare%26rft.stitle%253DDiabetes%2BCare%26rft.issn%253D0149-5992%26rft.aulast%253DBarnett%26rft.auinit1%253DA.%2BH.%26rft.volume%253D29%26rft.issue%253D6%26rft.spage%253D1282%26rft.epage%253D1287%26rft.atitle%253DAn%2BOpen%252C%2BRandomized%252C%2BParallel-Group%2BStudy%2Bto%2BCompare%2Bthe%2BEfficacy%2Band%2BSafety%2BProfile%2Bof%2BInhaled%2BHuman%2BInsulin%2B%2528Exubera%2529%2BWith%2BMetformin%2Bas%2BAdjunctive%2BTherapy%2Bin%2BPatients%2BWith%2BType%2B2%2BDiabetes%2BPoorly%2BControlled%2Bon%2Ba%2BSulfonylurea.%26rft_id%253Dinfo%253Adoi%252F10.2337%252Fdc05-1879%26rft_id%253Dinfo%253Apmid%252F16732009%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=diacare&resid=29/6/1282&atom=%2Febmed%2F11%2F6%2F176.atom [3]: /embed/inline-graphic-1.gif [4]: /embed/inline-graphic-2.gif [5]: /embed/inline-graphic-3.gif [6]: /embed/inline-graphic-4.gif [7]: /embed/inline-graphic-5.gif [8]: /embed/inline-graphic-6.gif
Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. (2001)

In this study, a hyaluronan-binding complex, which we termed Metastatin, was isolated from bovine cartilage by affinity chromatography and found to have both antitumorigenic and antiangiogenic properties. Metastatin was able to block the formation of tumor nodules in the lungs of mice inoculated with B16BL6 melanoma or Lewis lung carcinoma cells. Single i.v. administration of Metastatin into chicken embryos inhibited the growth of both B16BL6 mouse melanoma and TSU human prostate cancer cells growing on the chorioallantoic membrane. The in vivo biological effect may be attributed to the antiangiogenic activity because Metastatin is able to inhibit the migration and proliferation of cultured endothelial cells as well as vascular endothelial growth factor-induced angiogenesis on the chorioallantoic membrane. In each case, the effect could be blocked by either heat denaturing the Metastatin or premixing it with hyaluronan, suggesting that its activity critically depends on its ability to bind hyaluronan on the target cells. Collectively, these results suggest that Metastatin is an effective antitumor agent that exhibits antiangiogenic activity.
Supplementary Table S1 from Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors (2023)

&lt;p&gt;Supplementary Table S1 STARS Scores&lt;/p&gt;
Supramolecular Ladders:  Self-Assembly Fintium to Adfintium (2006)

We provide a review that describes the design and formation of supramolecular ladders in the solid state. Supramolecular ladders have been reported in the context of both metal−organic and purely organic single- and multiple-component solids. Supramolecular ladders are based on self-assembly processes propagated both finitely and infinitely. We focus on the properties that such ladders provide solids, as well as applications in the context of predictable dimensional design.