gebhart/patrepeval huggingface dataset:
The impact of projection lens polarization properties on lithographic process at hyper-NA (2007)

The continuous implementation of novel technological advances in optical lithography is pushing the technology to ever smaller feature sizes. For instance, it is now well recognized that the 45nm node will be executed using state-of-the-art ArF (193nm) hyper-NA immersion-lithography. Nevertheless, a substantial effort will be necessary to make imaging enhancement techniques like hyper-NA immersion technology, polarized illumination or sophisticated illumination modes routinely available for production environments. In order to support these trends, more stringent demands need to be placed on the lithographic optics. Although this holds for both the illumination unit and the projection lens, this paper will focus on the latter module. Today, projection lens aberrations are well controlled and their lithographic impact is understood. With the advent of imaging enhancement techniques such as hyper-NA immersion lithography and the implementation of polarized illumination, a clear description and control of the state of polarization throughout the complete optical system is required. Before polarization was used to enhance imaging, the imaging properties at each field position of the lens could be fully characterized by 2 pupil maps: a phase map and a transmission map. For polarized imaging, these two maps are replaced by a 2x2 complex Jones matrix for each point in the pupil. Although such a pupil of Jones matrices (short: Jones pupil) allows for a full and accurate description of the physical imaging, it seems to lack transparency towards direct visualization and lithographic imaging relevance. In this paper we will present a comprehensive method to decompose the Jones pupils into quantities that represent a clear physical interpretation and we will study the relevance of these quantities for the imaging properties of lithography lenses.
From Parameter Extraction, Variability Models to Yield Prediction (2018)

We will discuss methods and workflow of variability analysis and yield prediction for integrated photonic circuits, describing the process from wafer-scale parameter extraction over spatial variability modelling to layout-aware yield prediction of photonic circuits.
Data from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; In breast cancer models, combination epigenetic therapy with a DNA methyltransferase inhibitor and a histone deacetylase inhibitor led to reexpression of genes encoding important therapeutic targets, including the estrogen receptor (ER). We conducted a multicenter phase II study of 5-azacitidine and entinostat in women with advanced hormone-resistant or triple-negative breast cancer (TNBC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients received 5-azacitidine 40 mg/m&lt;sup&gt;2&lt;/sup&gt; (days 1–5, 8–10) and entinostat 7 mg (days 3, 10) on a 28-day cycle. Continuation of epigenetic therapy was offered with the addition of endocrine therapy at the time of progression [optional continuation (OC) phase]. Primary endpoint was objective response rate (ORR) in each cohort. We hypothesized that ORR would be ≥20% against null of 5% using Simon two-stage design. At least one response was required in 1 of 13 patients per cohort to continue accrual to 27 per cohort (type I error, 4%; power, 90%).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; There was one partial response among 27 women with hormone-resistant disease (ORR = 4%; 95% CI, 0–19), and none in 13 women with TNBC. One additional partial response was observed in the OC phase in the hormone-resistant cohort (&lt;i&gt;n&lt;/i&gt; = 12). Mandatory tumor samples were obtained pre- and posttreatment (58% paired) with either up- or downregulation of ER observed in approximately 50% of posttreatment biopsies in the hormone-resistant, but not TNBC cohort.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Combination epigenetic therapy was well tolerated, but our primary endpoint was not met. OC phase results suggest that some women benefit from epigenetic therapy and/or reintroduction of endocrine therapy beyond progression, but further study is needed. &lt;i&gt;Clin Cancer Res; 23(11); 2691–701. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Contribution à l'intégration des machines à vecteurs de support au sein des systèmes de reconnaisance de formes : application à la lecture automatique de l'écriture manuscrite (2007)

Durant ces dernières années, les machines à vecteurs de support (SVM) ont démontré maintes reprises leur supériorité en termes de généralisation. L'objectif de cette thèse de doctorat a alors consisté à isoler les principaux problèmes liés à l'intégration des SVM au sein de systèmes de reconnaissance de formes et notamment des systèmes de lecture automatique de l'écriture manuscrite et à y apporter des éléments de réponse. Nous nous sommes ainsi intéressés à la résolution de problèmes multi-classes, à l'estimation de probabilités a posteriori d'appartenance aux différentes classes, à l'accélération de la prise de décision et enfin à la combinaison avec une approche de classification agissant par modélisation de manière à pouvoir traiter efficacement à la fois les données ambiguës et les données aberrantes.&#13;\n&#13;\n
Diastereoselective Synthesis of γ-Substituted 2-Butenolides via (CDC)-Rh-Catalyzed Intermolecular Hydroalkylation of Dienes with Silyloxyfurans (2016)

Catalytic intermolecular hydroalkylation of dienes with silyloxyfuran nucleophiles is reported. Reactions are catalyzed by 5 mol % of a (CDC)-Rh complex and proceed in up to 87% yield and 6:1 dr (syn/anti) to provide allylic butenolides bearing vicinal stereocenters. Reactions proceed with terminal aryl and alkyl dienes and with modified silyl enol ether nucleophiles including a thiophenone variant. Utility of the products is demonstrated in the synthesis of a polypropionate anti,syn-stereotriad.
Up-modulation of the expression of functional keratinocyte growth factor receptors induced by high cell density in the human keratinocyte HaCaT cell line. (2000)

Keratinocyte growth factor (KGF) is involved in the control of proliferation and differentiation of human keratinocytes. It binds to, and activates, the tyrosine kinase KGF receptor (KGFR), a splicing transcript variant of the fibroblast growth factor receptor 2. We have previously shown (C. Marchese et al., Cell Growth Differ., 8: 989-997, 1997) that differentiation of primary cultured keratinocytes triggered by high Ca2+ concentrations in the growing medium induced up-regulation of KGFR expression, which suggested that KGFR may play a crucial role in the control of the proliferative/differentiative program during transition from basal to suprabasal cells. Here we analyzed the process of modulation of the expression of KGFRs in the human keratinocyte cell line HaCaT, widely used as a model to study keratinocyte differentiation. Western blot and double immunofluorescence for KGFR and the K1 differentiation marker showed that cell differentiation and stratification induced by confluence and high cell density correlated with an increase in KGFR expression. KGFRs, present on suprabasal differentiated cells, appeared to be efficiently tyrosine-phosphorylated by KGF, which indicated that the receptors up-regulated by differentiation can be functionally activated by ligand binding. Bromodeoxyuridine incorporation assay revealed that a significant portion of suprabasal differentiated cells expressing KGFR seemed to be still able to synthesize DNA and to proliferate in response to KGF, which suggested that increased KGFR expression may be required for retention of the proliferative activity.
Superoxide Modulates Myogenic Contractions of Mouse Afferent Arterioles (2011)

Reactive oxygen species enhance or impair autoregulation. Because superoxide is a vasoconstrictor, we tested the hypothesis that stretch generates superoxide that mediates myogenic responses. Increasing perfusion pressure of mouse isolated perfused renal afferent arterioles from 40 to 80 mm Hg reduced their diameter by 13.3±1.8% (P<0.001) and increased reactive oxygen species (ethidium: dihydroethidium fluorescence) by 9.8±2.3% (P<0.05). Stretch-induced fluorescence was reduced significantly (P<0.05) by incubation with Tempol (3.7±0.8%), pegylated superoxide dismutase (3.2±1.0%), or apocynin (3.5±0.9%) but not by pegylated catalase, L-nitroarginine methylester, or Ca(2+)-free medium, relating it to Ca(2+)-independent vascular superoxide. Compared with vehicle, basal tone and myogenic contractions were reduced significantly (P<0.05) by pegylated superoxide dismutase (5.4±0.8), Tempol (4.1±1.0%), apocynin (1.0±1.3%), and diphenyleneiodinium (3.9±0.9%) but not by pegylated catalase (10.1±1.6%). L-Nitroarginine methylester enhanced basal tone, but neither it (15.8±3.3%) nor endothelial NO synthase knockout (10.2±1.8%) significantly changed myogenic contractions. Tempol had no further effect after superoxide dismutase but remained effective after catalase. H(2)O(2) >50 μmol/L caused contractions but at 25 μmol/L inhibited myogenic responses (7.4±0.8%; P<0.01). In conclusion, increasing the pressure within afferent arterioles led to Ca(2+)-independent increased vascular superoxide production from nicotinamide adenine dinucleotide phosphate oxidase, which enhanced myogenic contractions largely independent of NO, whereas H(2)O(2) impaired pressure-induced contractions but was not implicated in the normal myogenic response.
Chaperone Properties of Pdia3 Participate in Rapid Membrane Actions of 1α,25-Dihydroxyvitamin D3 (2013)

Protein disulfide isomerase family A, member 3 (Pdia3) mediates many of the plasma membrane (PM)-associated rapid responses to 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3). It is not well understood how Pdia3, which is an endoplasmic reticulum (ER) chaperone, functions as a PM receptor for 1α,25(OH)2D3. We mutated 3 amino acids (K214 and R282 in the calreticulin interaction site and C406 in the isomerase catalytic site), which are important for Pdia3's ER chaperone function, and examined their role in responses to 1α,25(OH)2D3. Pdia3 constructs with and without the ER retention signal KDEL were used to investigate the PM requirement for Pdia3. Finally, we determined whether palmitoylation and/or myristoylation were required for Pdia3-mediated responses to 1α,25(OH)2D3. Overexpressing the Pdia3 R282A mutant in MC3T3-E1 cells increased PM phospholipase A2-activating protein, Rous sarcoma oncogene (c-Src), and caveolin-1 but blocked increases in 1α,25(OH)2D3-stimulated protein kinase C (PKC) seen in cells overexpressing wild-type Pdia3 (Pdia3Ovr cells). Cells overexpressing Pdia3 with K214A and C406S mutations had PKC activity comparable to untreated controls, indicating that the native response to 1α,25(OH)2D3 also was blocked. Overexpressing Pdia3[-KDEL] increased PM localization and augmented baseline PKC, but the stimulatory effect of 1α,25(OH)2D3 was comparable to that seen in wild-type cultures. In contrast, 1α,25(OH)2D3 increased prostaglandin E2 in Pdia3[±KDEL] cells. Although neither palmitoylation nor myristoylation was required for PM association of Pdia3, myristoylation was needed for PKC activation. These data indicate that both the chaperone functional domains and the subcellular location of Pdia3 control rapid membrane responses to 1α,25(OH)2D3.
Antitumor activity of new liposomal prodrug of mitomycin C in multidrug resistant solid tumor: Insights of the mechanism of action (2007)

The antitumor activity of a novel thiolytically cleavable lipid-based prodrug of mitomycin C (MMC) delivered by STEALTH liposomes (SL) was studied in drug resistant human ovarian carcinoma A2780/AD model and compared with free MMC and both free and SL forms of an established anticancer drug--doxorubicin (DOX). It was found that SL-prodrug (SL-pMMC) possessed enhanced antitumor activity when compared with the parent MMC, free DOX, and SL-DOX. An observance of the high antitumor efficiency of SL-pMMC was a result of its preferential accumulation in the tumor by the enhanced permeability and retention (EPR) effect, suppression of multidrug resistance (MDR) associated with P-glycoprotein and MRP drug efflux pumps, activation of caspase-dependent apoptosis signaling pathways and suppression of antiapoptotic cellular defense by increasing the BAX/BCL2 ratio. Consequently, the described SL-pMMC formulations can be considered good candidates for the chemotherapy of multidrug resistant tumors.
Data Compression Conference (DCC'06) (2006)

Compressed sensing has received significant attention in recent years, primarily as a mathematical phenomenon. There has been, on the other hand, significantly less attention paid towards incorporation of compressed-sensing methodology into practical signal-processing applications. In this talk, we consider compressed sensing in the context of several image and video applications. The foundations of our discussion rest on a recent block-based strategy for compressed-sensing recovery of a single still image. In our approach, block-based random image sampling is coupled with a projection-driven compressed-sensing recovery that encourages sparsity in the domain of an image transform simultaneously with a smooth reconstructed image. The proposed approach yields images with quality that matches or exceeds that produced by a popular, yet computationally expensive, technique which minimizes total variation. This still-image reconstruction is then extended to multiview image sets, incorporating inter-image disparity compensation into the image-recovery process in order to take advantage of the high degree of inter-image correlation common to multiview scenarios. Finally, a similar approach is adopted for the reconstruction of video in which each frame has been subject to block-based random projections, and motion estimation and motion compensation across an entire group of frames informs the compressed-sensing recovery process.
Electrode kinetics of Cu–SiO2-based resistive switching cells: Overcoming the voltage-time dilemma of electrochemical metallization memories (2009)

The kinetics of the switching process in Cu–SiO2-based electrochemical metallization memory cells was investigated as a function of the switching voltage and the SiO2 film thickness. We observe an exponential dependence of the switching rate on the switching voltage and no significant thickness dependence in the range from 5to20nm SiO2. We conclude from our data that the cathodic electrodeposition represents the rate-limiting step of the switching kinetics. The voltage-time dilemma seems to be overcome by the exponential dependence of the switching rate in combination with a threshold voltage presumably originating from a nucleation overpotential.
Methods for determining enzymatic activity comprising heating and agitation of closed volumes (2023)

Methods for determining thermophilic enzymatic activity include heating a substrate solution in a plurality of closed volumes to a predetermined reaction temperature. Without opening the closed volumes, at least one enzyme is added, substantially simultaneously, to the closed volumes. At the predetermined reaction temperature, the closed volumes are agitated and then the activity of the at least one enzyme is determined. The methods are conducive for characterizing enzymes of high-temperature reactions, with insoluble substrates, with substrates and enzymes that do not readily intermix, and with low volumes of substrate and enzyme. Systems for characterizing the enzymes are also disclosed.
Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid (2020)

Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neurochemical connectome. Our micro-invasive platform, composed of a nanofluidic pump coupled to a membrane-free probe, enables sampling multiple neural biomarkers in parallel. This platform outperforms the state of the art in low-flow pumps by offering low volume control (single stroke volumes, <3 nl) and bidirectional fluid flow (<100 nl/min) with negligible dead volume (<30 nl) and has been validated in vitro, ex vivo, and in vivo in rodents. ISF samples (<1.5 μL) can be processed via liquid chromatography-tandem mass spectrometry. These label-free liquid biopsies of the brain could yield a deeper understanding of the onset, mechanism, and progression of diverse neural pathologies.
Unidentified Listeria ‐like bacteria isolated from cheese (1998)

Unidentified Listeria-like bacteria, which lack only one of the phenotypic characteristics used to confirm Listeria spp., were isolated from cheese during routine analysis for Listeria monocytogenes. The VIDAS Listeria assay and the Listeria specific PCR or DNA probe assays used did not identify these strains as Listeria species. This group of bacteria was studied for its homogeneity using rep-PCR and PFGE. Sequence analysis of the 16S rRNA gene showed a homology of 94% to established Listeria spp., implicating a closer relationship than that between Listeria spp. and Brochothrix spp.
Finite Horizon QoS Prediction of Reconfigurable Firm Real-Time Sytems (2006)

Updating real-time system software is often needed in response to errors and added requirements to the software. Stopping a running application, updating the software, and then restarting the application is not suitable for systems with high availability requirements. On the other hand, dynamically updating a system may increase the execution time of the tasks, thus, degrading the performance of the system. Degradation is not acceptable for performancecritical real-time systems as there are strict requirements on the performance. In this paper we present an approach that enables dynamic reconfiguration of a real-time system, where the performance of the system during a reconfiguration satisfies a given worst-case performance specification. Evaluation shows that the presented method is efficient in guaranteeing the worst-case performance of dynamically reconfigurable firm real-time systems.
Conducting Instant Adhesives by Grafting of Silane Polymer onto Expanded Graphite (2014)

A "grafting to" methodology for the attachment of a silane based polymer (SG) onto functionalized graphitic platelets is demonstrated. The siloxy end groups of the modifier were further cross-linked without addition of any external curative. These sterically stabilized nanoplatelets with a high grafting density ensured complete screening of the attractive interparticle interactions. As a result, a better dispersion of platelets was observed compared to the physically mixed platelets in the polymer matrix (SUG). The larger size of the polymer tethered graphitic particles and the greater extent of heat liberated due to grafting resulted in a higher enthalpic contribution in the case of SG compared to SUG. This makes the formation of SG thermodynamically more favorable compared to SUG. Presence of a hierarchical spatial arrangement with a good dispersion of graphitic platelets was observed within the siloxane matrix in the case of SG compared to SUG. The nanoparticle tethered composite generated exhibited an "instant" conducting adhesive behavior. The adhesive properties of the SG were found to be increased due to grafting of graphitic platelets when compared with the neat polymer. Further, SG exhibited a conductive character whereas the neat polymer and SUG demonstrated an insulating character.
Dehydro‐α‐lapachone isolated from Catalpa ovata stems: activity against plant pathogenic fungi (2006)

The methanol extract of stems of Catalpa ovata G Don exhibits potent in vivo antifungal activity against Magnaporthe grisea (Hebert) Barr (rice blast) on rice plants, Botrytis cinerea Pers ex Fr (tomato grey mould) and Phytophthora infestans (Mont) de Bary (tomato late blight) on tomato plants, Puccinia recondita Rob ex Desm (wheat leaf rust) on wheat plants and Blumeria graminis (DC) Speer f. sp. hordei Marchal (barley powdery mildew) on barley plants. An antifungal substance was isolated and identified as dehydro-alpha-lapachone from mass and nuclear magnetic resonance spectral data. It completely inhibited the mycelial growth of B. cinerea, Colletotrichum acutatum Simmonds, Colletotrichum gloeosporioides Simmonds, M. grisea and Pythium ultimum Trow over a range of 0.4-33.3 mg litre(-1). It also controlled the development of rice blast, tomato late blight, wheat leaf rust, barley powdery mildew and red pepper anthracnose (Colletotrichum coccodes (Wallr) S Hughes). The chemical was particularly effective in suppressing red pepper anthracnose by 95% at a concentration of 125 mg litre(-1).
Composites of Silk Nanofibrils and Metal–Organic Framework Nanosheets for Fluorescence-Based Sensing and UV Shielding (2023)

Silk fibroin, a widely used natural biopolymer, presents remarkable flexibility and biodegradability, making it of great interest as a polymer matrix for functional composite materials. Herein, composites of silk nanofibrils and metal–organic framework (MOF) nanosheets were successfully fabricated by a coincubation and coassembly process. Under heat incubation, silk fibroin self-assembled into one-dimensional nanofibrils, while MOF nanosheets simultaneously covered or wrapped on the silk nanofibrils in a water suspension. Transparent composite membranes were obtained from their water suspensions by the solution casting method. The regenerated silk nanofibrils formed a network structure, and the integrated MOF nanosheets (0.1 to 3.0 wt %) endowed the composites with aggregation-induced emission luminogen (AIEgen)-based fluorescence. The fluorescence intensity of the composites was significantly enhanced owing to the interfacial interactions between silk nanofibrils and MOF nanosheets. The composite membranes also offer excellent UV shielding while maintaining optical transparency in the visible spectrum. This work provides an efficient pathway to fabricate luminescent silk protein-based composites for functional materials such as fluorescence sensing and anticounterfeiting.
Synthesis, DNA binding and biological evaluation of synthetic precursors and novel analogs of netropsin (1989)

A series of oligopeptides have been synthesized that are structurally related to the natural agent netropsin. The binding constants to double-stranded polynucleotides as well as the cytostatic activity against both murine human tumor cell lines and the in vitro activity against a range of DNA and RNA viruses have been determined for these novel compounds and some of their synthetic precursors. 1-Methyl-5-nitropyrrole-2-carboxylic acid methyl ester (4), N-[[1-methyl-4-(1-methyl-4-nitropyrrole-2-carboxamido)pyrrol-2- yl]carbonyl]-L-alanine tert-butyl ester (28), and N-[[1-methyl-4-(1-methyl-4-nitropyrrole-2-carboxamido)pyrrol-2- yl]carbonyl]-L-alanyl-L-alanine tert-butyl ester (29) showed modest inhibitory effect on tumor cell proliferation (CD50 = 26-85 micrograms/mL). Of all the compounds that were evaluated, 28 proved the most potent antiviral agent. It was inhibitory to parainfluenza-3 virus and Coxsackie virus B4 in Vero cells at a concentration of 20 micrograms/mL.
Energy-Efficient Optical Transport Capacity Scaling Through Spatial Multiplexing (2011)

We discuss the role of parallel transport options such as spatial multiplexing or multiband transmission in the capacity scaling of optical transport systems. Taking current experimental spectral efficiency records as a baseline, a system supporting 20 b/s/Hz over 1500 km can be about 100 times more energy efficient when it is built using spatial multiplexing than when it is built using a single waveguide at high capacity.