gebhart/patrepeval huggingface dataset:
A Diagnostic Algorithm for Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Lumbar Disc Hernia or Lumbar Spinal Stenosis: Personal Experience and Review of the Literature. (2016)

Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare systemic vasculitis and is difficult to diagnose. EGPA has a number of symptoms including peripheral dysesthesia caused by mononeuropathy multiplex, which is similar to radiculopathy due to lumbar disc hernia or lumbar spinal stenosis. Therefore, EGPA patients with mononeuropathy multiplex often visit orthopedic clinics, but orthopedic doctors and spine neurosurgeons have limited experience in diagnosing EGPA because of its rarity. We report a consecutive series of patients who were initially diagnosed as having lumbar disc hernia or lumbar spinal stenosis by at least 2 medical institutions from March 2006 to April 2013 but whose final diagnosis was EGPA. All patients had past histories of asthma or eosinophilic pneumonia, and four out of five had peripheral edema. Laboratory data showed abnormally increased eosinophil counts, and nerve conduction studies of all patients revealed axonal damage patterns. All patients recovered from paralysis to a functional level after high-dose steroid treatment. We shortened the duration of diagnosis from 49 days to one day by adopting a diagnostic algorithm after experiencing the first case.
Sustainable EPM rubber compounds (2020)

Two important aspects that should be considered when designing new, sustainable rubber products are the bio-based character of the rubber compound ingredients and the recyclability of the vulcanized rubber product. In this work, both are addressed by compounding a thermoreversible cross-linked EPM rubber with pyrolysis carbon black and squalane as sustainable filler and plasticizer, respectively. The resulting rubber product is fully reprocessable in the melt and it displays material properties comparable to those of compounds with conventional additives with high retention of the material properties upon reprocessing.
Dynamical fragmentation ofC60ions (1992)

The distribution of fragments resulting from collisions between 50--200-keV ${\mathrm{C}}_{60}^{+}$ ions and ${\mathrm{H}}_{2}$ and He is found to follow approximately a simple power law I(m)=${\mathit{cp}}^{\mathit{m}}$ where p is a constant depending on both energy and target gas, and m is the number of missing ``pairs'' of carbon atoms. Based on this observation, a new dynamical fragmentation model involving the ratio of two characteristic times is proposed. In collisions by 300-keV ${\mathrm{C}}_{60}^{++}$ ions, the singly charged products are distributed quite differently, which implies the first evidence of the presence of charge-separation reactions.
On the efficacy of fine-grained traffic splitting protocolsin data center networks (2011)

Multi-rooted tree topologies are commonly used to construct high-bandwidth data center network fabrics. In these networks, switches typically rely on equal-cost multipath (ECMP) routing techniques to split traffic across multiple paths, such that packets within a flow traverse the same end-to-end path. Unfortunately, since ECMP splits traffic based on flow-granularity, it can cause load imbalance across paths resulting in poor utilization of network resources. More fine-grained traffic splitting techniques are typically not preferred because they can cause packet reordering that can, according to conventional wisdom, lead to severe TCP throughput degradation. In this work, we revisit this fact in the context of regular data center topologies such as fat-tree architectures. We argue that packet-level traffic splitting, where packets of a flow are sprayed through all available paths, would lead to a better load-balanced network, which in turn leads to significantly more balanced queues and much higher throughput compared to ECMP.
Non-dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica. (1984)

We have previously described an idiotype (Id460) that transiently dominates anti-2,4-dinitrophenyl (DNP) antibody responses of mice that possess the appropriate Igh-V and V kappa genotypes. Normal serum has significant levels of Id460 that does not bind DNP, and hybridomas derived from spleen cell fusions that produce monoclonal antibodies with these characteristics have been generated. Many of these monoclonal, Id460-positive antibodies bind the opportunistic mouse pathogen Pasteurella pneumotropica. P. pneumotropica induces a marked increase in serum Id460 titers without significantly increasing serum anti-DNP titers. Both normal serum and P. pneumotropica-induced Ig460-positive immunoglobulin specifically bind to P. pneumotropica. These results suggest that the normal serum Id460-positive immunoglobulin is induced by environmentally encountered antigens on P. pneumotropica. We propose that this naturally occurring Id460 activates antiidiotypic regulatory cells that in turn promote production of Id460-positive anti-DNP antibody following DNP-ovalbumin immunization. These data are compatible with those obtained in several other idiotypic systems that suggest that dominant idiotypes may be associated with antibodies that have been evolutionarily selected for expression because of their specificity for antigens on environmentally encountered pathogens.
View-Based 3-D Model Retrieval: A Benchmark (2018)

View-based 3-D model retrieval is one of the most important techniques in numerous applications of computer vision. While many methods have been proposed in recent years, to the best of our knowledge, there is no benchmark to evaluate the state-of-the-art methods. To tackle this problem, we systematically investigate and evaluate the related methods by: 1) proposing a clique graph-based method and 2) reimplementing six representative methods. Moreover, we concurrently evaluate both hand-crafted visual features and deep features on four popular datasets (NTU60, NTU216, PSB, and ETH) and one challenging real-world multiview model dataset (MV-RED) prepared by our group with various evaluation criteria to understand how these algorithms perform. By quantitatively analyzing the performances, we discover the graph matching-based method with deep features, especially the clique graph matching algorithm with convolutional neural networks features, can usually outperform the others. We further discuss the future research directions in this field.
Reconstruction of Failed Lumbar Surgery with Narrow AO DCP Plates for Spinal Arthrodesis (1991)

Forty-five patients underwent surgical reconstruction with transpedicular fixation of the lumbar spine with narrow AO DCP plates. Preoperatively, all patients underwent spinal imaging with either magnetic resonance imaging, computed tomography, or myelogram as well as provocative discography to determine the location and the number of symptomatic segments. The minimum follow-up in this series was 2 years. The determination of solid posterior fusion in the presence of plate instrumentation was difficult. The patients in the series were classified as having 1) solid fusion; 2) radiographic flaws within the posterolateral fusion without implant failure; or 3) frank pseudarthrosis with implant failure. Thirty-six (80%) of the patients had a solid fusion, 9 of whom required an additional anterior interbody fusion to obtain symptom control. Twenty percent of the patients in the series had radiographic evidence of reabsorption without implant failure. Four patients in the series (8.8%) had screw breakage, three of which required anterior interbody fusions. The highest rate of reabsorption and pseudarthrosis implant failure was in the 12 patients who had three-level instrumentation; 33% of these patients required anterior interbody fusion to obtain a solid arthrodesis. The average preoperative pain scale was 8.9, and the average postoperative pain scale was a 3.3. Twenty-two patients in the series were cigarette smokers and had a slightly lower fusion rate than non-smokers. They did, however, have a higher use of narcotics after surgery. Forty percent of the patients in this series continued to have radiculopathy after their reconstruction. This study demonstrates the utility of transpedicular fixation in salvage lumbar surgery in obtaining a solid arthrodesis with a beneficial clinical result. Anterior interbody fusions are highly successful in the management of pseudarthrosis and implant failure after transpedicular instrumentation.
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells. (1985)

Dihydrofluorouracil (FUH2), the initial catabolite of 5-fluorouracil (FUra), was examined to determine whether this derivative had antitumor activity or host cell (bone marrow) toxicity. Studies were undertaken with Ehrlich ascites tumor and bone marrow cells isolated from CF-1 mice. Cells were exposed for 1 h either to no drug (control) or to varying concentrations, ranging from 1 to 250 microM, of either FUra, FUH2, or alpha-fluoro-beta-alanine. Cells were then cultured and colony formation was assessed after 10 to 14 days. Ehrlich ascites tumor cells were more sensitive to FUra [50% lethal dose (LD50) = 18 microM] than to FUH2 [LD50 = 50 microM], with no sensitivity to alpha-fluoro-beta-alanine even at 250 microM. Bone marrow cells had a toxicity profile similar to that of FUra (LD50 = 10 microM) but were relatively insensitive to FUH2 (LD50 greater than 250 microM), with no sensitivity to alpha-fluoro-beta-alanine. Subsequent studies examined colony formation of the human breast carcinoma cell line MCF-7 following 1 h exposure to varying concentrations of FUra and FUH2. These cells were less sensitive to both FUra (LD50 approximately 80 microM) and FUH2 (LD50 approximately 350 microM). Initial studies on the mechanism of toxicity of FUH2 demonstrated that this FUra catabolite could produce inhibition of thymidylate synthase activity in Ehrlich ascites tumor cells with a pattern similar to that resulting from exposure to FUra. This is the first study to demonstrate that FUH2 (a quantitatively important catabolite of FUra) is cytotoxic, and it suggests that FUH2 may contribute to the toxicity of FUra in vivo, possibly by being anabolized to FUra.
Host-Guest Complexation of Oxaliplatin and Para-Sulfonatocalix[n]Arenes for Potential Use in Cancer Therapy (2020)

<i>P</i>-sulfonatocalix[n]arenes have demonstrated a great potential for encapsulation of therapeutic drugs via host-guest complexation to improve solubility, stability, and bioavailability of encapsulated drugs. In this work, guest-host complexes of a third-generation anticancer drug (oxaliplatin) and <i>p</i>-4-sulfocalix[n]arenes (<i>n</i> = 4 and 6; <i>p</i>-SC4 and <i>p</i>-SC6, respectively) were prepared and investigated, using <sup>1</sup>H NMR, UV, Job's plot analysis, and DFT calculations, for use as cancer therapeutics. The peak amplitude of the prepared host-guest complexes was linearly proportional to the concentration of oxaliplatin in the range of 1.0 × 10<sup>-5</sup> M<sup>-1</sup> to 2.1 × 10<sup>-4</sup> M<sup>-1</sup>. The reaction stoichiometry between either <i>p</i>-SC4 or <i>p</i>-SC6 and oxaliplatin in the formed complexes was 1:1. The stability constants for the complexes were 5.07 × 10<sup>4</sup> M<sup>-1</sup> and 6.3 × 10<sup>4</sup> M<sup>-1</sup>. These correspond to complexation free energy of -6.39 and -6.52 kcal/mol for <i>p</i>-SC4 and <i>p</i>-SC6, respectively. Complexation between oxaliplatin and <i>p</i>-SC4 or <i>p</i>-SC6 was found to involve hydrogen bonds. Both complexes exhibited enhanced biological and high cytotoxic activities against HT-29 colorectal cells and MCF-7 breast adenocarcinoma compared to free oxaliplatin, which warrants further investigation for cancer therapy.
Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells (2018)

Fluorescent VEGF-A isoforms have been evaluated for their ability to discriminate between VEGFR2 and NRP1 in real-time ligand binding studies in live cells using BRET. To enable this, we synthesized single-site (N-terminal cysteine) labeled versions of VEGF<sub>165</sub>a, VEGF<sub>165</sub>b, and VEGF<sub>121</sub>a. These were used in combination with N-terminal NanoLuc-tagged VEGFR2 or NRP1 to evaluate the selectivity of VEGF isoforms for these two membrane proteins. All fluorescent VEGF-A isoforms displayed high affinity for VEGFR2. Only VEGF<sub>165</sub>a-TMR bound to NanoLuc-NRP1 with a similar high affinity (4.4 nM). Competition NRP1 binding experiments yielded a rank order of potency of VEGF<sub>165</sub>a > VEGF<sub>189</sub>a > VEGF<sub>145</sub>a. VEGF<sub>165</sub>b, VEGF-Ax, VEGF<sub>121</sub>a, and VEGF<sub>111</sub>a were unable to bind to NRP1. There were marked differences in the kinetic binding profiles of VEGF<sub>165</sub>a-TMR for NRP1 and VEGFR2. These data emphasize the importance of the kinetic aspects of ligand binding to VEGFR2 and its co-receptors in the dynamics of VEGF signaling.
Abstract 4597: Chemopreventive and chemotherapeutic potential of blueberry and black raspberry against lung cancer using mouse models (2011)

Abstract Berries, particularly blueberry (BB), black raspberry (BRB), are gaining increased attention for their chemopreventive and chemotherapeutic activities and have been tested in limited clinical studies with mixed results. Previous studies with strawberry and BRB failed to elicit protection against NNK/PAH-induced lung carcinogenicity in the A/J mice (the Stoner studies). However, a low dose of a mixture of different berries (BB, BRB, blackberry, and strawberry) elicited modest inhibition of cigarette smoke-mediated lung carcinogenicity in our study. In this study we investigated chemopreventive and chemotherapeutic activities of BB and BRB using two different animal models: To determine the DNA adduct-inhibiting potential female A/J mice were provided AIN-93M diet or diets supplemented with lyophilized powder of BB or BRB (5% each, w/w) and then challenged with continuous low doses of dibenzo-[a,l]pyrene (DBP) by subcutaneous polymeric implants (two, 20 mm long, 1.4 mm dia; DBP load 5%). Three weeks later animals were euthanized and the target tissue (lung) DNA was analyzed by 32P-postlabeling assay. The DNA adduct burden (as adducts/109 nucleotides) in animals receiving the BB (67 ± 16), BRB (68 ± 9) diets was found to be unaffected compared with control diet (54 ± 17), indicating that the berry bioactives were ineffective against the DNA adduct-forming ability of DBP under the conditions used. To determine the chemotherapeutic potential, female nude mice received AIN-93M (control) diet or diet supplemented with a mixture of BB and BRB (2:1) and 4 days later inoculated with human lung cancer A549 cells (3×106 cells). Four weeks into the ongoing study, the berry diet has shown significant (nearly 60%) inhibition of the lung tumor xenograft (186 ± 117 versus 79 ± 47). The anti-tumor activity elicited by the berry diet in xenograft model is consistent with the anti-tumor activity of anthocyanidins reported by us in cell culture and nude mice (Kausar et al. AACR 51: 1884, 2010). In conclusion, our data suggest that the anti-lung cancer potential of the berries may be associated with mechanisms other than inhibition of carcinogen-induced DNA adducts. (Supported from CA-118114, KLCRP and Agnes Brown Duggan Endowment). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4597. doi:10.1158/1538-7445.AM2011-4597
Supplementary Figure 7 from αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor (2023)

&lt;p&gt;Full-size scans of PSA immunoblots shown in Figure 5.&lt;/p&gt;
Analysis of Single‐Carrier Communication Systems (2021)

This chapter discusses some of the fundamental concepts related to single-carrier communication. It focuses on the practical aspects of the implementation, analysis, and performance measurement of single-carrier systems. The chapter describes a single-carrier communication system in additive white Gaussian noise channel. Sample clock error is one of the most critical impairments in the model and the one that is described next (flat fading multipath channel). When the transmitted signal passes through a multipath radio channel where the relative path delays are on the order of a symbol period or more, then images of different symbols arrive at the same time. The dispersive channel, which is often referred as frequency selective channel, can be modeled as a linear, finite impulse response filter. A similar system model that is used for narrowband systems in dispersive channels can be used for direct spread code division multiple access systems.
Neural Maximum-a-Posteriori Beamforming for Ultrasound Imaging (2023)

Ultrasound imaging is an attractive imaging modality due to its low-cost and real-time feedback, although it often falls short in image quality compared to MRI and CT imaging. Conventional ultrasound image reconstruction, such as Delay-and-Sum beamforming, is derived from maximum-likelihood estimation. As such, no prior information is exploited in the image formation process, which limits potential image quality. Maximum-a-posteriori (MAP) beamforming aims to overcome this issue, but often relies on rough approximations of the underlying signal statistics. Deep learning based reconstruction methods have demonstrated impressive results over the past years, but often lack interpretability and require vast amounts of data.In this work we present a neural MAP beamforming technique, which efficiently combines deep learning in the MAP beamforming framework. We show that this model-based deep learning approach can achieve high-quality imaging, improving over the state-of-the-art, without compromising the real-time abilities of ultrasound imaging.
Domains Responsible for Constitutive and Ca2+-Dependent Interactions between Calmodulin and Small Conductance Ca2+-Activated Potassium Channels (1999)

Small conductance Ca(2+)-activated potassium channels (SK channels) are coassembled complexes of pore-forming SK alpha subunits and calmodulin. We proposed a model for channel activation in which Ca2+ binding to calmodulin induces conformational rearrangements in calmodulin and the alpha subunits that result in channel gating. We now report fluorescence measurements that indicate conformational changes in the alpha subunit after calmodulin binding and Ca2+ binding to the alpha subunit-calmodulin complex. Two-hybrid experiments showed that the Ca(2+)-independent interaction of calmodulin with the alpha subunits requires only the C-terminal domain of calmodulin and is mediated by two noncontiguous subregions; the ability of the E-F hands to bind Ca2+ is not required. Although SK alpha subunits lack a consensus calmodulin-binding motif, mutagenesis experiments identified two positively charged residues required for Ca(2+)-independent interactions with calmodulin. Electrophysiological recordings of SK2 channels in membrane patches from oocytes coexpressing mutant calmodulins revealed that channel gating is mediated by Ca2+ binding to the first and second E-F hand motifs in the N-terminal domain of calmodulin. Taken together, the results support a calmodulin- and Ca(2+)-calmodulin-dependent conformational change in the channel alpha subunits, in which different domains of calmodulin are responsible for Ca(2+)-dependent and Ca(2+)-independent interactions. In addition, calmodulin is associated with each alpha subunit and must bind at least one Ca2+ ion for channel gating. Based on these results, a state model for Ca2+ gating was developed that simulates alterations in SK channel Ca2+ sensitivity and cooperativity associated with mutations in CaM.
Silicon (100)/SiO2 by ToF-SIMS (2015)

The authors report the time-of-flight secondary ion mass spectrometry of Si (100)/SiO2. Both positive and negative ion spectra were obtained using a cluster ion source (Bi32+ primary ions at 50 keV). Si+ is the base peak in positive ion mode. The negative ion spectrum shows signals characteristic of the native oxide: SiO2−, SiO2H−, SiO3−, and SiO3H−.
Integrated Optical Pulse Shaping (1993)

Advances in pulsed lasers have resulted in a growing need for methods and devices for controlling and exploiting the temporal bandwidth of pulsed fields. Mode-locked diode sources with subpicosecond pulse widths have recently been integrated [1]. We consider high-resolution integrated systems for modulating the bandwidth of such pulses. These systems are capable of creating arbitrarily-shaped optical pulses with bandwidths limited only by the bandwidth of the pulsed source. Applications for pulse-shaping devices exist in communications, optical computing, and nonlinear spectroscopy.
A distributed, real-time and non-parametric approach to demand response in the smart grid (2015)

This paper considers a novel approach to demand response in a smart grid, wherein a set of flexible loads with given energy requirements and deadlines for completion adjust their instantaneous power consumption in such a way as to make the aggregate total power consumption on the grid as smooth as possible. Each load periodically adjusts its own power level using only a minimal amount of feedback i.e. the aggregate power consumption observed in the previous period, and knowledge of its own energy requirement and deadline. Our approach allows for a fully distributed, real-time implementation and does not require any knowledge of arrival process statistics or forecasts of future load. We illustrate the working of our algorithm with a detailed simulation of generation and load for a fictional small city modeled after the city of Ames, IA using data from a variety of sources. In this simulation, charging electric vehicles serve as flexible loads. We also present an approximate analysis of the bahaviour of flexible loads in our scheme based on a continuous time version of the proposed algorithm to gain insight into its properties and limitations.
Improvements in pig agriculture through gene editing (2022)

Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations, chief among them is the requirement for the beneficial trait to exist within the population. Desirable alleles in geographically isolated breeds, or breeds selected for a different conformation and commercial application, and more importantly animals from different genera or species cannot be introgressed into the population via selective breeding. Additionally, linkage disequilibrium results in low heritability and necessitates breeding over successive generations to fix a beneficial trait within a population. Given the need to sustainably improve animal production to feed an anticipated 9 billion global population by 2030 against a backdrop of infectious diseases and a looming threat from climate change, there is a pressing need for responsive, precise, and agile breeding strategies. The availability of genome editing tools that allow for the introduction of precise genetic modification at a single nucleotide resolution, while also facilitating large transgene integration in the target population, offers a solution. Concordant with the developments in genomic sequencing approaches, progress among germline editing efforts is expected to reach feverish pace. The current manuscript reviews past and current developments in germline engineering in pigs, and the many advantages they confer for advancing animal agriculture.