gebhart/patrepeval huggingface dataset:
Vehicle Vertical Wearing Index (V2 WI): active monitoring of wearing and aging of vertical-dynamics components in four-wheeled vehicles (2020)

Being able to assess the state-of-health of a vehicle opens of course many possible applications. All the more so if the ongoing degradation of the monitored components can be provided continuously as the vehicle life extends over time. In modern shared mobility systems, thanks to which migration from ownership to usership models should eventually take place, developing means to actively monitor the state of the vehicle fleet is crucial to improve business models and feasible and predictive maintenance plans. Within this challenging context, the present paper focuses on the monitoring of the vehicle vertical dynamics, to understand, from the analysis of measured data, which is the combined effect of driving-style and introduce road pavement roughness in determining the usage profile of the vertical-dynamics-related components of the vehicle, mostly the suspensions system. The proposed cost function concisely represents such wearing process, with the advantage of not requiring detailed parametric models of the vehicle dynamics and of the components themselves. The approach is tested on more than 9.000 km of trips carried out on four different vehicles, allowing to prove the effectiveness and generality of the approach.
Hemodynamic effects of labetalol, an alpha and beta adrenergic blocking agent, in hypertensive subjects. (1977)

Labetalol was administered to six hypertensive subjects in increasing doses for seven days. A decrease in both supine and standing arterial pressure and heart rate was observed with no change in cardiac output and few side effects. Exercise tolerance was unaltered by the drug, but the heart rate and arterial pressure response to exercise were significantly blunted. The infusion rate of isoproterenol required to produce tachycardia was increased sevenfold by 800 mg/day labetalol and tenfold by 1600 mg/day. More than twice the control dose of phenylephrine was required during labetalol therapy to produce a rise in diastolic arterial pressure reflex tachycardia to amyl nitrite-induced hypotension was attenuated. These studies indingina pectoris.
Supplementary Table 3 from Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier (2023)

&lt;p&gt;PDF file - 57K, Selectivity of GNE-317 against a Panel of 59 Kinases. GNE-317 was Tested at 1 �M in the Invitrogen SelectScreen&lt;/p&gt;
Synthesis and investigation of the boron cluster anion [7-(2′-pyridyl)-7,8-nido-dicarbaundecaborate] and its protonated form (2007)

The structurally chiral [7-(2'-pyridyl)-7,8-nido-C(2)B(9)H(11)](-), [](-), anion was prepared by a partial degradation reaction of 1-(2'-pyridyl)-1,2-closo-C(2)B(10)H(11). From this anion a protonated specie, H[7-(2'-pyridyl)-7,8-nido-C(2)B(9)H(11)] , and a tetramethylammonium salt, [NMe(4)][7-(2'-pyridyl)-7,8-nido-C(2)B(9)H(11)], [NMe(4)][] can be obtained. The (1)H{(11)B} DNMR study on in the temperature range from 298 to 203 K identified the weakly basic nitrogen atom in the pyridine ring as the proton accepting site in solid state and low temperature and revealed pronounced weakening of the nitrogen-proton interaction while the temperature increases. Capillary electrophoresis and X-ray diffraction confirmed the pyridine nitrogen atom as the proton binding site. Separation of the electrophoretically pure racemic [7-(2'-pyridyl)-7,8-nido-C(2)B(9)H(11)](-) ion into two peaks by the chiral selector beta-cyclodextrine has been achieved.
Serotype O18 avian pathogenic and neonatal meningitisEscherichia colistrains employ similar pathogenic strategies for the onset of meningitis (2015)

Neonatal meningitis Escherichia coli K1 (NMEC) are thought to be transmitted from mothers to newborns during delivery or by nosocomial infections. However, the source of E. coli K1 causing these infections is not clear. Avian pathogenic E. coli (APEC) have the potential to cause infection in humans while human E. coli have potential to cause colibacillosis in poultry, suggesting that these strains may lack host specificity. APEC strains are capable of causing meningitis in newborn rats; however, it is unclear whether these bacteria use similar mechanisms to that of NMEC to establish disease. Using four representative APEC and NMEC strains that belong to serotype O18, we demonstrate that these strains survive in human serum similar to that of the prototypic NMEC strain E44, a derivative of RS218. These bacteria also bind and enter both macrophages and human cerebral microvascular endothelial cells (HCMEC/D3) with similar frequency as that of E44. The amino acid sequences of the outer membrane protein A (OmpA), an important virulence factor in the pathogenesis of meningitis, are identical within these representative APEC and NMEC strains. Further, these strains also require FcγRI-α chain (CD64) and Ecgp96 as receptors for OmpA in macrophages and HCMEC/D3, respectively, to bind and enter these cells. APEC and NMEC strains induce meningitis in newborn mice with varying degree of pathology in the brains as assessed by neutrophil recruitment and neuronal apoptosis. Together, these results suggest that serotype O18 APEC strains utilize similar pathogenic mechanisms as those of NMEC strains in causing meningitis.
MEMS/MOEMS foundry services at INO (2010)

In the MEMS manufacturing world, the "fabless" model is getting increasing importance in recent years as a way for MEMS manufactures and startups to minimize equipment costs and initial capital investment. In order for this model to be successful, the fabless company needs to work closely with a MEMS foundry service provider. Due to the lack of standardization in MEMS processes, as opposed to CMOS microfabrication, the experience in MEMS development processes and the flexibility of the MEMS foundry are of vital importance. A multidisciplinary team together with a complete microfabrication toolset allows INO to offer unique MEMS foundry services to fabless companies looking for low to mid-volume production. Companies that benefit from their own microfabrication facilities can also be interested in INO's assistance in conducting their research and development work during periods where production runs keep their whole staff busy. Services include design, prototyping, fabrication, packaging, and testing of various MEMS and MOEMS devices on wafers fully compatible with CMOS integration. Wafer diameters ranging typically from 1 inch to 6 inches can be accepted while 8-inch wafers can be processed in some instances. Standard microfabrication techniques such as metal, dielectric, and semiconductor film deposition and etching as well as photolithographic pattern transfer are available. A stepper permits reduction of the critical dimension to around 0.4 &#956;m. Metals deposited by vacuum deposition methods include Au, Ag, Al, Al alloys, Ti, Cr, Cu, Mo, MoCr, Ni, Pt, and V with thickness varying from 5 nm to 2 &#956;m. Electroplating of several materials including Ni, Au and In is also available. In addition, INO has developed and built a gold black deposition facility to answer customer's needs for broadband microbolometric detectors. The gold black deposited presents specular reflectance of less than 10% in the wavelength range from 0.2 &#956;m to 100 &#956;m with thickness ranging from 20 to 35 &#956;m and a density of 0.3% the bulk density of gold. Two Balzers thin-film deposition instruments (BAP-800 and BAK-760) permit INO to offer optical thin film manufacturing. Recent work in this field includes the design and development of a custom filter for the James Webb Space Telescope (JWST) as collaboration with the Canadian company ComDEV. An overview of the different microfabrication foundry services offered by INO will be presented together with the most recent achievements in the field of MEMS/MOEMS.
Single-photon detectors for ultra-low-voltage time-resolved emission measurements of VLSI circuits (2011)

Using Time Resolved Emission (TRE) to measure electrical signals inside VLSI CMOS circuits in a non-invasive fashion is a very powerful technique. However, node scaling and the related supply voltage reduction have created significant challenges. In this paper, we investigate the limits of established and prototype single photon detectors for future low voltage applications. In particular the performances of a state of the art InGaAs Single Photon Avalanche Photodiode (SPAD) and Superconducting Single-Photon Detector (SSPD) are reported and compared for low voltage applications using test vehicles fabricated in IBM 65 nm and 45 nm SOI technologies.
Modeling Valance Change Memristor Device: Oxide Thickness, Material Type, and Temperature Effects (2016)

This paper presents a physics-based mathematical model for anionic memristor devices. The model utilizes Poisson- Boltzmann equation to account for temperature effect on device potential at equilibrium and comprehends material effect on device behaviors. A detailed MATLAB based algorithm is developed to clarify and simplify the simulation environment. Moreover, the provided model is used to simulate and predict the effect of oxide thickness, material type, and operating temperatures on the electrical characteristics of the device. The parameters of the proposed model are tuned and validated using experimental data of a fabricated wire based NbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> junction. This device is attractive for neuromorphic and computing applications, where multilevel state is desirable. The value of this contribution is to provide a framework intended to simulate anionic memristor devices using correlated mathematical models. In addition, the model can be used to explore device materials and predict its performance.
Zwitterionic Copolymerization: Synthesis of Cyclic Gradient Copolymers (2011)

Schnell reich werden: Die zwitterionische Copolymerisation von δ-Valerolacton (VL) und ε-Caprolacton (CL) bietet eine nützliche Route zur Synthese von cyclischen Gradienten-Copolymeren. Die schnellere Ringöffnung von VL im Vergleich zu CL beim Einwirken N-heterocyclischer Carbene, verbunden mit einer genügend langen Lebensdauer der wachsenden Zwitterionen, führt zu einer Polymerstruktur aus VL-reichen Sequenzen, die in CL-reiche Sequenzen in einem cyclischen Makromolekül übergehen (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Rational Design of Peptides Derived from Odorant-Binding Proteins for SARS-CoV-2-Related Volatile Organic Compounds Recognition (2022)

Peptides are promising molecular-binding elements and have attracted great interest in novel biosensor development. In this study, a series of peptides derived from odorant-binding proteins (OBPs) were rationally designed for recognition of SARS-CoV-2-related volatile organic compounds (VOCs). Ethanol, nonanal, benzaldehyde, acetic acid, and acetone were selected as representative VOCs in the exhaled breath during the COVID-19 infection. Computational docking and prediction tools were utilized for OBPs peptide characterization and analysis. Multiple parameters, including the docking model, binding affinity, sequence specification, and structural folding, were investigated. The results demonstrated a rational, rapid, and efficient approach for designing breath-borne VOC-recognition peptides, which could further improve the biosensor performance for pioneering COVID-19 screening and many other applications.
A new optical transducer to measure damped harmonic motion (1983)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Erhard Feige, Thomas B. Clegg, John W. Poulton; A new optical transducer to measure damped harmonic motion. American Journal of Physics 1 October 1983; 51 (10): 954–955. https://doi.org/10.1119/1.13375 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
Disturbance Rejection Through an External Model (1990)

This paper considers the use of external models for the cancellation of disturbances that can be regarded as output of stable (in the sense of Lyapunov) autonomous systems. The external model is set up outside the feedback loop so that the design of the feedback controller is accomplished without favoring particular disturbances. External model controllers can, therefore, be add-on devices to existing control systems. An application to track-following in a disk-file actuator system is presented.
Differential In Vitro Immortalization Capacity of Eleven, Probable High-Risk Human Papillomavirus Types (2013)

Epidemiological studies identified 12 high-risk HPV (hrHPV) types and 8 probable/possible hrHPV types that display different cancer risks. Functional studies on transforming properties of hrHPV are mainly limited to HPV16 and -18, which induce immortalization of human foreskin keratinocytes (HFKs) by successive bypass of two proliferative life span barriers, senescence and crisis. Here, we systematically compared the in vitro immortalization capacities, as well as influences on p53, pRb, hTERT, growth behavior, and differentiation capacity, of nine hrHPV types (HPV16, -18, -31, -33, -35, -45, -51, -52, and -59), and two probable hrHPV types (HPV66 and -70). By retroviral transduction, the respective E6/E7 coding sequences were expressed in HFKs from two or three independent donors. Reduced p53 levels and low-level hTERT expression in early-passage cells, as seen in HPV16-, -31-, -33-, and -35-, and to a lesser extent HPV18-transduced HFKs, was associated with continuous growth and an increased immortalization capacity. Less frequent immortalization by HPV45 and -51 and immortalization by HPV66 and -70 was preceded by an intervening period of strongly reduced growth (crisis) without prior increase in hTERT expression. Immortalization by HPV59 was also preceded by a period crisis, despite the onset of low hTERT expression at early passage. HPV52 triggered an extended life span but failed to induce immortality. Variations in p53 and pRb levels were not correlated with differences in alternative E6/E7 mRNA splicing in all hrHPV-transduced HFKs. On collagen rafts, transductants showed disturbed differentiation reminiscent of precancerous lesions. In conclusion, in vitro oncogenic capacities differ between the established hrHPV types, and both some established and probable hrHPV types display weak or moderate immortalization potential.
A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum (2021)

Post-transcriptional processes mediated by mRNA binding proteins represent important control points in gene expression. In eukaryotes, mRNAs containing specific AU-rich motifs are regulated by binding of tristetraprolin (TTP) family tandem zinc finger proteins, which promote mRNA deadenylation and decay, partly through interaction of a conserved C-terminal CNOT1 binding (CNB) domain with CCR4-NOT protein complexes. The social ameba Dictyostelium discoideum shared a common ancestor with humans more than a billion years ago, and expresses only one TTP family protein, TtpA, in contrast to three members expressed in humans. Evaluation of ttpA null-mutants identified six transcripts that were consistently upregulated compared to WT during growth and early development. The 3'-untranslated regions (3'-UTRs) of all six 'TtpA-target' mRNAs contained multiple TTP binding motifs (UUAUUUAUU), and one 3'-UTR conferred TtpA post-transcriptional stability regulation to a heterologous mRNA that was abrogated by mutations in the core TTP-binding motifs. All six target transcripts were upregulated to similar extents in a C-terminal truncation mutant, in contrast to less severe effects of analogous mutants in mice. All six target transcripts encoded probable membrane proteins. In Dictyostelium, TtpA may control an 'RNA regulon', where a single RNA binding protein, TtpA, post-transcriptionally co-regulates expression of several functionally related proteins.
Synthesis and Catalytic Application of Palladium Pyrazolin-3-ylidene Complexes (2004)

Oxidative addition of a 3-halo 1,2-disubstituted pyrazolium salt to a palladium(0) complex leads to the formation of the first reported palladium pyrazolin-3-ylidene complex. Comparison of the new system with the analogous imidazolin-2-ylidene complex in Heck catalysis shows higher yields for the new system by a factor of 2.
Ketenimines as intermediates to heterocycles. Part 3. Rearrangement of 3-iminoisoxazolines to 2-imino-oxazolines (1981)

N-Substituted hydroxylamines (2) add to 2-benzoyl-N,2-diphenylvinylideneamine (1) and the adducts are easily dehydrated to give the 3-iminoisoxazolines (4). Compounds (4) with 2-aryl substituents rearrange spontaneously to give the 2-imino-oxazolines (5) or (6), but the 2-methyl derivative is more stable and only rearranges on heating. 2-Imino-3-acylaziridines (8) or (9) are assumed to be the intermediates; the expected 2-imino-oxazoline (5b) was isolated among the products during an attempted synthesis of 1,3-diphenyl-2-phenylimino-3-benzoylaziridine (8b) from benzoylphenylcarbene and diphenylcarbodi-imide.
Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway (2016)

Baicalein, a natural flavonoid obtained from the rhizome of <i>Scutellaria baicalensis</i> Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and associated mechanisms in melanoma cells have not been extensively studied. The current study examined the effects of baicalein on cell motility and anti-invasive activity using mouse melanoma B16F10 cells. Within the noncytotoxic concentration range, baicalein significantly inhibited the cell motility and invasiveness of B16F10 cells in a concentration-dependent manner. Baicalein also reduced the activity and expression of matrix metalloproteinase (MMP)-2 and -9; however, the levels of tissue inhibitor of metalloproteinase-1 and -2 were concomitantly increased. The inhibitory effects of baicalein on cell motility and invasiveness were found to be associated with its tightening of tight junction (TJ), which was demonstrated by an increase in transepithelial electrical resistance and downregulation of the claudin family of proteins. Additionally, treatment with baicalein markedly reduced the expression levels of lipopolysaccharide-induced phosphorylated Akt and the invasive activity in B16F10 cells. Taken together, these results suggest that baicalein inhibits B16F10 melanoma cell migration and invasion by reducing the expression of MMPs and tightening TJ through the suppression of claudin expression, possibly in association with a suppression of the phosphoinositide 3-kinase/Akt signaling pathway.
An Agent-Based Approach to Virtual Power Plants of Wind Power Generators and Electric Vehicles (2013)

Wind power is gaining in significance as an important renewable source of clean energy. However, due to their inherent uncertainty, wind generators are often unable to participate in the forward electricity markets like the more predictable and controllable conventional generators. Given this, virtual power plants (VPPs) are being advocated as a solution for increasing the reliability of such intermittent renewable sources. In this paper, we take this idea further by considering VPPs as coalitions of wind generators and electric vehicles, where wind generators seek to use electric vehicles (EVs) as a storage medium to overcome the vagaries of generation. Using electric vehicles in this manner has the advantage that, since the number of EVs is increasing rapidly, no initial investment in dedicated storage is needed. In more detail, we first formally model the VPP and then, through an operational model based on linear programming, we show how the supply to the Grid and storage in the EV batteries can be scheduled to increase the profit of the VPP, while also paying for the storage using a novel scheme. The feasibility of our approach is examined through a realistic case-study, using real wind power generation data, corresponding electricity market prices and electric vehicles' characteristics.
SATE (Aryl) Phosphotriester Series. Part 2. Stability Studies and Physicochemical Parameters (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Real-Time Human-Voice Enhancement for a Hose-Shaped Rescue Robot Based on Multi-Channel Low-Rank Sparse Decomposition (2017)

This paper presents a real-time human-voice enhancement method for a hose-shaped rescue robot based on multi-channel low-rank sparse decomposition. Although microphone arrays equipped on hose-shaped robots are crucial for finding victims under collapsed buildings, human voices captured by the microphone array are contaminated by environment-dependent and non-stationary ego-noise. Our method decomposes multi-channel amplitude spectrograms into sparse and low-rank components (human voice and noise) without any prior training. This decomposition is conducted with a state-space model representing the dynamics of these components in a mini-batch manner. Experimental results show that the performance difference between our method and its offline version is less than 3dB in signal-to-distortion ratio.
Proteome changes induced by Pyrenophora tritici-repentis ToxA in both insensitive and sensitive wheat indicate senescence-like signaling (2015)

This is the first report of a biochemical response in an insensitive cultivar in this plant-pathogen interaction. Findings support the involvement of ethylene, and the activation of complementary pathways in sensitive versus insensitive wheat cultivars responding to Ptr ToxA. The nature of the system permits using purified toxin to mimic disease, which eliminates the pathogen proteome and ensures a synchronous response in inoculated leaves.
The Design and Analysis of Compliant MEMS Using the Pseudo-Rigid-Body Model (1997)

Abstract Because of the difficulty of fabricating rigid-body joints and assembling parts in micro-electro-mechanical systems (MEMS), compliant mechanisms offer several advantages to MEMS designers. However, motion of compliant segments generally involves large, non-linear deflections which are difficult to predict using linear beam theory. This paper discusses MEMS design using the pseudo-rigid-body model. This model has been developed to permit simplified prediction of nonlinear deflections in compliant mechanisms, allowing traditional mechanism theory to be used in design. The design process is validated by testing MEMS structures designed using this model. The model successfully predicted the motion of the compliant MEMS, even for very large deflection paths. The mechanisms designed and tested achieved larger deflections and more complex motion than was previously possible.