gebhart/patrepeval huggingface dataset:
Structural Characterization and Identification of Post‐Translational Modifications of Human Eukaryotic Initiation Factor 3 (eIF3) by FTICR Mass Spectrometry (2006)

Mammalian eIF3 is the largest initiation factor with a mass of about 600 kDa and contains at least 12 non‐identical subunits ranging in mass from 25 to 167 kDa. eIF3 is almost universally required for both cap‐dependent and cap‐independent initiation, and plays a central role in binding of initiator methionyl‐tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex. The molecular mechanisms by which eIF3 exert these functions are poorly understood. The overall goal of this project is to understand how the mammalian eIF3 contributes to the initiation mechanism, and how the eIF3 controls ribosomal subunit association. The present study is focused on elucidating the structure/function of eIF3 and how eIF3 activity may be modulated by covalent modifications of its subunits. To answer these questions, FTICR mass spectrometry has been used as a powerful tool for structure analysis of biopolymers which simultaneously can provide high mass resolution (&gt;10 6 ), mass‐determination accuracy (&lt;1 ppm), sensitivity and MS n capabilities. By nanoLC‐MS/MS analysis of the eIF3 tryptic digest using a hybrid linear ion trap‐FTICR mass spectrometer (Thermo Electron, San Jose, CA) we found that the eIF3 protein complex consists of at least 13 non‐identical subunits, the 13 th subunit being identified as GA17, a 42.5 kDa protein that contains a PCI domain like those found in eIF3a, eIF3c, and eIF3e subunits. Furthermore, five phosphorylation sites on the eIF3b, eIF3c, eIF3g and eIF3j subunits and several other PTMs (e.g. loss of N‐terminal methionine and/or N‐terminal acetylation) were identified.
Glycosylation changes in hepatocellular carcinoma (2007)

A68 Increasing incidence of hepatocellular carcinoma (HCC) was associated with hepatitis C (HCV) viral infection. Our study of HCC in Egypt, a country with an epidemic of HCV, identified a set of glycans as candidate markers for early detection of HCC. Glycans enzymatically released from serum proteins were analyzed by MALDI-TOF/TOF following solid phase permethylation. Analysis of less than 0.05 ml of serum allowed relative quantification of 80 glycans. Approximately half of the glycans changed significantly at p
Bileaflet mechanical prostheses performance in mitral position (1999)

This non-randomized prospective observational evaluation of the CarboMedics and St. Jude Medical prostheses has not revealed any differentiation in performance of the prostheses. The study serves as a single institution experience with the potential for future comparative evaluation.
Wafer‐Scale Organic Complementary Inverters Fabricated with Self‐Assembled Monolayer Field‐Effect Transistors (2020)

Abstract Self‐assembled monolayers (SAMs) of π‐conjugated molecules can achieve robust charge transport by the formation of ordered 2D layers at the desired regions, which enable their application for organic integrated circuits. Here, the self‐assembled monolayer field‐effect transistor concept is applied as a scalable method to realize fully integrated complementary inverters by stepwise semiconductor deposition. Two‐component stacked bilayer ambipolar transistors are fabricated by semiconducting self‐assembled monolayers (n‐SAM or p‐SAM) as the bottom layer and a complementary thin‐film semiconductor layer on top. The integrated complementary metal‐oxide‐semiconductor like (CMOS‐like) inverter achieves proper logic performances. The nanometer‐thin monolayers exhibit effective charge transport and their flat, homogeneous surfaces benefit the interconnected growth of the top layer. Furthermore, by controlling the solution‐based and region‐selective deposition of p‐ and n‐type SAMs, fully integrated CMOS inverters are realized on wafer scale by photolithography for the first time. The CMOS inverters show a nearly 100% yield with a gain up to 48, and noise margin 3.68 V (73.6% of V DD /2). The strategy of semiconducting SAMs for digital logic gates demonstrates a reliable approach for sophisticated large‐area circuits.
Novel Si-CNT/polyaniline nanocomposites as Lithium-ion battery anodes for improved cycling performance (2017)

A novel nanocomposite consisting of gas-phased produced Si nanoparticles, carbon nanotubes (CNTs), and polyaniline (PANi) is developed as an anode material (Si-CNT/PANi) for lithium-ion batteries. This nanocomposite integrates the merits from its three components, where Si nanoparticles provide high capacity, CNTs act as an electrically conductive and mechanically flexible network, and PANi coating further enhances the electrical conductivity and protects the silicon structure. An anode made of this nanocomposite shows a high reversible capacity of 2430 mAh/g with good capacity retention over 500 cycles compared to pristine Si. The Si-CNT/PANi nanocomposite also demonstrated a high Coulombic efficiency and improved rate-capabilities.
<title>Optical simulation of imaging systems using multiple turbulent phase screens</title> (1994)

We discuss a technique based on nonlinear and adaptive optics for simulation of phase distortion effects in imaging systems. This technique uses a nonlinear two-dimensional optical feedback system to produce a controllable spatially and temporally varying chaotic intensity distribution. The intensity pattern is converted into a spatially varying thin phase screen using a spatial phase modulator. A chaotic phase distortion is then introduced into an imaging system's output image by propagation through the phase screen. A deformable (adaptive) mirror with computer control is used for simulation of large-scale phase distortions.
MAP-MRI diffusion estimates are biased by simultaneous multi-slice acceleration (2023)

Advanced diffusion MRI models are being explored to study the complex microstructure of the brain with higher accuracy. However, these techniques require long acquisition times. Simultaneous multi-slice (SMS) accelerates data acquisition by exciting multiple image slices simultaneously and separating the overlapping slices using a mathematical model. However, SMS acceleration introduces increased noise in reconstructed images and crosstalk between simultaneously excited slices. These compounded effects from SMS acceleration could affect tissue microstructure parameters derived from advanced diffusion MRI models.
AI-guided discovery of the invariant host response to viral pandemics (2020)

<b>Evidence before this study:</b> The SARS-CoV-2 pandemic has inspired many groups to find innovative methodologies that can help us understand the host immune response to the virus; unchecked proportions of such immune response have been implicated in fatality. We searched GEO and ArrayExpress that provided many publicly available gene expression data that objectively measure the host immune response in diverse conditions. However, challenges remain in identifying a set of host response events that are common to every condition. There are no studies that provide a reproducible assessment of prognosticators of disease severity, the host response, and therapeutic goals. Consequently, therapeutic trials for COVID-19 have seen many more 'misses' than 'hits'. This work used multiple (> 45,000) gene expression datasets from GEO and ArrayExpress and analyzed them using an unbiased computational approach that relies upon fundamentals of gene expression patterns and mathematical precision when assessing them.<b>Added value of this study:</b> This work identifies a signature that is surprisingly conserved in all viral pandemics, including Covid-19, inspiring the nomenclature ViP-signature. A subset of 20-genes classified disease severity in respiratory pandemics. The ViP signatures pinpointed the nature and source of the 'cytokine storm' mounted by the host. They also helped formulate precise therapeutic goals and rationalized the repurposing of FDA-approved drugs.<b>Implications of all the available evidence:</b> The ViP signatures provide a quantitative and qualitative framework for assessing the immune response in viral pandemics when creating pre-clinical models; they serve as a powerful unbiased tool to rapidly assess disease severity and vet candidate drugs.
New pancreas cancers cell lines that represent distinct stages of ductal differentiation. (1995)

Levels of CK7 and MUC1 are associated with less differentiated cultures. The new cell lines should be useful tools to study the cell biology of exocrine pancreas cancer.
Phase Noise Compensation for 5G NR System with DFT-s-OFDM in the Presence of Timing Errors (2022)

Millimeter wave (mmWave) systems beyond 52.6 GHz carrier frequency are considered as one of the ways to notably improve the data rate of fifth generation New Radio (5G NR) systems. A large amount of spectrum available in such frequency bands can address the capacity demands of the current and future cellular systems. However, the performance of the practical devices operating in the mmWave bands is degraded by phase noise (PN) due to the impairments of the transceiver local oscillators. To address this issue, phase tracking reference signals (PT-RS) are introduced in 5G NR system to mitigate the PN impact at the receiver side. In this paper, we analyze the performance of the conventional PN tracking algorithms with discrete-Fourier-transform spread orthogonal frequency division multiplexing (DFT-s-OFDM) waveform and demonstrate significant performance losses of 5G NR uplink transmission in the presence of timing synchronization errors and PN. A novel PN compensation algorithm and a new PT-RS structure robust to timing errors is proposed. The PN tracking technique and PT-RS enhancements presented in the paper can be efficiently realized in 5G NR system.
A novel bioassay to evaluate the potential of Beauveria bassiana strain NI8 and the insect growth regulator novaluron againstLygus lineolaris on a non-autoclaved solid artificial diet (2014)

A non-autoclaved solid diet was used to evaluate the entomopathogenic fungus Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Clavicipitaceae) strain NI8 and the insect growth regulator novaluron (Diamond® 0.83EC insecticide) for control of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae). The diet was composed of toasted wheat germ, ground lima bean meal, soy flour, yolk of chicken eggs, inhibitor, and agar. It was prepared in one step by blending the ingredients in boiling water. The diet was used to bioassay L. lineolaris from the second instar to the adult stage. Fourth and fifth instars and adults of L. lineolaris were more susceptible than second and third instars to infection by B. bassiana, whereas second, third, and fourth instars had higher mortality than fifth instars 10 days after exposure to novaluron. No effects on longevity were observed in adults treated with novaluron when compared with the control, but longevity was significantly different from that of adults exposed to B. bassiana. Adults of L. lineolaris were maintained for over a month without changing the diet. The non-autoclaved diet is semi-liquid before it cools, which facilitates the mechanics of diet packaging similar to food packaging or lepidopteran diet preparation. This solid artificial diet for Lygus bugs provides improved research capacity for studying the ecology and susceptibility of Lygus spp. to a number of different control agents, including beneficial organisms, insect pathogens, and insecticidal toxins being developed for transgenic technologies.
Graphene Wrinkles: Enhanced Peltier Effect in Wrinkled Graphene Constriction by Nano‐Bubble Engineering (Small 14/2020) (2020)

In article number 1907170, Zhenghua An, Zengfeng Di, and co-workers leverage scanning thermal microscopy to visualize the nanoscale Peltier effect across graphene wrinkles on germanium substrate, which attributes to the non-equilibrium charge transport through interlayer tunneling across the van der Waals barrier formed in graphene wrinkles.
The Role of Unicompartmental Knee Arthroplasty Versus Total Knee Arthroplasty in Providing Maximal Performance and Satisfaction (2008)

Unicondylar knee arthroplasty (UKA) and total knee arthroplasty (TKA) are both recommended for the treatment of medial compartment osteoarthritis in the varus knee. Some authors report favorable functional results and patient satisfaction from TKA on the basis of extensive, long-term success of knee arthroplasty. Others cite the arduous rehabilitation and bone loss associated with traditional knee arthroplasty, opting for UKA, especially in young, high-demand patients. This article reviews the elements of successful UKA. It emphasizes the advantages of UKA versus traditional knee arthroplasty and minimally invasive TKA.
Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging (2021)

Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded <i>in vivo</i> without any long-term toxicological consequences to the organism. Here, we developed biodegradable harmonophores (bioharmonophores) that consist of polymer-encapsulated, self-assembling peptides that generate a strong SHG signal. When functionalized with tumor cell surface markers, these reporters can target single cancer cells with high detection sensitivity in zebrafish embryos <i>in vivo</i>. Thus, bioharmonophores will enable an innovative approach to cancer treatment using targeted high-resolution optical imaging for diagnostics and therapy.
Regulating Competing Supramolecular Interactions Using Ligand Concentration (2016)

The complexity of biomolecular systems inevitably leads to a degree of competition between the noncovalent interactions involved. However, the outcome of biological processes is generally very well-defined often due to the competition of these interactions. In contrast, specificity in synthetic supramolecular systems is usually based on the presence of a minimum set of alternative assembly pathways. While the latter might simplify the system, it prevents the selection of specific structures and thereby limits the adaptivity of the system. Therefore, artificial systems containing competing interactions are vital to stimulate the development of more adaptive and lifelike synthetic systems. Here, we present a detailed study on the self-assembly behavior of a C2v-symmetrical tritopic molecule, functionalized with three self-complementary ureidopyrimidinone (UPy) motifs. Due to a shorter linker connecting one of these UPys, two types of cycles with different stabilities can be formed, which subsequently dimerize intermolecularly via the third UPy. The UPy complementary 2,7-diamido-1,8-naphthyridine (NaPy) motif was gradually added to this mixture in order to examine its effect on the cycle distribution. As a result of the C2v-symmetry of the tritopic UPy, together with small differences in binding strength, the cycle ratio can be regulated by altering the concentration of NaPy. We show that this ratio can be increased to an extent where one type of cycle is formed almost exclusively.
Behavior of Cyclic Fatigue Cracks in Monolithic Silicon Nitride (1995)

Cyclic fatigue‐crack propagation behavior in monolithic silicon nitride is characterized in light of current fatiguecrack growth models for ceramics toughened by grainbridging mechanisms, with specific emphasis on the role of load ratio. Such models are based on diminished cracktip shielding in the crack wake under cyclic loads due to frictional‐wear degradation of the grain‐bridging zone. The notion of cyclic crack growth promoted by diminished shielding is seen to be consistent with measured (long‐crack) growth rates, fractography, in situ crack‐profile analyses, and measurements of back‐face strain compliance. Growth rates are found to display a much larger dependence on the maximum applied stress intensity, K max than on the applied stress‐intensity range, Δ K , with behavior described by the relationship da/dN ∞ K 29 max ΔK 1.3 . Fatigue thresholds similarly exhibit a marked dependence on the load ratio, R = K min / K max ; such effects are shown to be inconsistent with traditional models of fatigue‐crack closure. In particular, when characterized in terms of K max growth rates below ∼10 −9 m/cycle exhibit an inverse dependence on load ratio, an observation which is consistent with the grain‐bridging phenomenon; specifically, with increasing R, the sliding disance between the grain bridges is decreased, leading to less frictional wear, and hence less degradation in shielding, per loading cycle. The microstructural origins of such behavior are discussed.
The classification, fusion, and parallelization of array language primitives (1994)

We present a classification scheme for array language primitives that quantifies the variation in parallelism and data locality that results from the fusion of any two primitives. We also present an algorithm based on this scheme that efficiently determines when it is beneficial to fuse any two primitives. Experimental results show that five LINPACK routines report 50% performance improvement from the fusion of array operators.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supraclavicular Approach to the Brachial Plexus. (2023)

The supraclavicular dissection of the brachial plexus is reliable with consistent landmarks and can be carried out in a stepwise fashion.
PPPS-2013: UNM transparent cathode experiments revisited (2013)

The transparent cathode (TC) invented at the University of New Mexico (UNM) showed high output powers, high efficiency and stable operation in the 2pi-mode over a wide range of magnetic field compared to the solid cathode when tested in the standard A6 magnetron.
Inhibition of Fatty Acid Amide Hydrolase (FAAH) Reduces Contextually Elicited Gaping, a Measure of Anticipatory Nausea in Rats (2014)

Introduction: Chemotherapy-induced nausea and vomiting are among the most challenging and troubling symptoms reported in patients receiving chemotherapy. Reports have suggested the involvement of the endocannabinoid system (including FAAH inhibition) in acute and anticipatory nausea (AN), a conditional association between treatment cues such as the clinic setting and the experience of nausea. In the current study, IW-7229, a potent, indole ketoamide FAAH inhibitor, was assessed in a rat model of AN. Methods: Rats were given 4 pairings of a novel context with lithium chloride (LiCl), and then 72 hours after the final pairing, were given a test for AN. For the AN test trial, they received either (a) intragastric (ig) pretreatments of vehicle (VEH) or IW-7229 (10, 30 or 100 mg/kg), or (b) they received a pretreatment of VEH or IW-7229 (10 mg/kg, ig), followed by an additional pretreatment of either VEH or a CB1 antagonist, SR141716 (2.5 mg/kg, ip). Two hours following the pretreatment, rats were placed in the conditioning chamber for 5 minutes while their orofacial reactions were videotaped and later scored for the number of gapes. Immediately following the AN test, rats were given a 15-min locomotor activity test to assess whether the drug produced any motor impairments. Results: IW-7229 (10 or 30 mg/kg, but not 100 mg/kg) reduced contextually elicited gaping reactions by 77% and 64% relative to VEH controls, respectively. The effect of IW-7229 (10 mg/kg) on reducing contextually-elicited gaping reactions was completely blocked by administration of SR141716. These effects occurred without producing any locomotor effects at the effective doses (10 or 30 mg/kg of IW-7229); however, at 100 mg/kg, IW-7229 did reduce locomotor activity (21% reduction relative to VEH controls). Conclusion: Inhibition of FAAH, with the FAAH inhibitor IW-7229 (10 and 30 mg/kg), reduces AN in rats, and this effect appears to be CB1 receptor-mediated, likely due to elevated endogenous anandamide levels that result from FAAH inhibition. These data support the potential utility of IW-7229 in AN and, as proof of concept has not yet been demonstrated for FAAH inhibition in the clinic, provide a novel avenue to pursue in its clinical development. Disclosure - Dr. Profy, Dr. Currie, and Dr. Segal are employees of Ironwood Pharmaceuticals. Dr. Carey is an employee of Teleos Therapeutics. This research was funded by Ironwood Pharmaceuticals.
Frequency stabilized optical comb source with high finesse intracavity etalon (2009)

Mode-locked lasers have applications in signal processing and communications such as analog to digital conversion, arbitrary waveform generation and wavelength division multiplexing. For such applications low noise and phase coherent frequency stabilized optical combs are needed. In this work we report a low noise, Pound-Drever Hall frequency stabilized, semiconductor mode-locked laser at 10.287GHz centered at 1550nm with 1000-Finesse sealed, ultralow insertion loss intracavity etalon. The output optical power of the mode locked laser is ~5mW.
Indirect Temperature Measurement of CPV Solar Cells Using Wavelength Shift of the Sub-Cells Luminescence Emission Peaks (2012)

Modern utility scale concentrator photovoltaic systems rely on the use of high performance multijunction solar cells to drive down the cost of solar generated electricity. In an effort to drive system performance up and reduce further manufacturing costs, Semprius is developing a novel class of High Concentration Photovoltaic (HCPV) modules using transfer printed micro-solar cells.1-4 These modules are designed to be manufactured using highly scalable manufacturing processes to drive production costs down and enable the generation of electricity at very competitive levelized cost of energy (LCOE) in high direct normal incidence areas. These modules currently achieve a word record conversion efficiency of 33.9% as independently verified by the Spanish Institute of Concentration Photovoltaic Systems (ISFOC) and the University of Madrid.5 Even though state of the art multijunction solar cells are nowadays capable of converting over 40% of the incoming Direct Normal solar Irradiance (DNI) into electricity,6-8 the remaining 60% of the energy is still lost into heat which needs to be efficiently extracted to prevent over-heating of the solar cells. Accurate measurements of the operating temperature of the solar cells are necessary in order to optimize a thermal management solution and to translate the current-voltage (IV) curves of modules measured indoor and on-sun.9 However, performing accurate measurements of the operating temperature of micro-solar cells is technically challenging. Standard thermocouples or non-contact infra-red techniques are respectively inappropriate or require the use of high sensitivity IR imagers which can’t be used to measure solar cells through optics. This paper presents an alternate measurement technique to indirectly measure the operating temperature of each subcell through the measurement of the wavelength-shift of their electro- or photo-luminescence emission profile.