gebhart/patrepeval huggingface dataset:
Abstract 292: PTC596 combination therapy for sarcoma (2019)

Abstract Sarcomas are rare cancers derived from mesenchymal tissues. Although rare, there are approximately 15,000 new cases of sarcoma diagnosed each year in the United States. Certain soft tissue sarcomas are treated with doxorubicin and olaratumabas first line, gemcitabine as second line, and often dacarbazine (DTIC) as third line. PTC596 is a first-in-class, oral investigational new drug that reduces levels of BMI1, a protein required for cancer stem cell survival. PTC596 acts by binding to tubulin causing a G2M cell cycle arrest. PTC596 lowers levels of BMI1 in preclinical tumor models and is generally well tolerated as a monotherapy at doses that result in preclinical target plasma concentrations. Efficacy of PTC596 was evaluated in a series of preclinical models. PTC596 delayed tumor growth as monotherapy and significantly enhanced, in combination, the activity of standard chemotherapeutics including gemcitabine, doxorubicin/ doxil, dacarbazine (DTIC), and other tubulin binding agents. Based on these results, a Ph1b clinical trial in patients with relapsed refractory leiomyosarcoma is to be initiated. It is a dose escalation study of a combination regimen of dacarbazine and PTC596 with the dose-limiting toxicity (DLT) to be determined using a continuous reassessment methodology. Previously, a Phase I multi-center dose escalation study was conducted in patients with advanced solid tumors. PTC596 was administered as an oral monotherapy in 4-week cycles using bodyweight-adjusted twice-per-week (biw) dosing. A maximum tolerated dose (MTD) was not determined though a well-tolerated recommended Phase 2 dose of 7mg/kg biw was identified. The most relevant toxicities observed were neutropenia, nausea, and vomiting which were generally mild to moderate, manageable and reversible. Citation Format: Marla Weetall, Art Branstrom, John Baird, Liang Cao, Josephine Sheedy, Kylie O'Keefe, Matthew Ingham, Gary K. Schwartz, Robert Spiegel, Edward O'Mara. PTC596 combination therapy for sarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 292.
Orientational order in systems of nanorods: side-by-side and end-to end controlled assembly using lyotropic chromonic materials (2009)

We describe a simple and universal technique of controlled non-covalent assembly of metallic nanorods (NRs) using self-assembled stacks of lyotropic chromonic molecules. Depending on the charge of the NRs, the chromonic stacks assemble them either end-to-end or side-by-side through anisotropic attractive forces. The anisotropically aggregated systems of NRs show pronounced changes in spectral properties as compared to those of individual NRs, with longitudinal and transverse plasmon peaks shifting accordingly to the geometry of assembly. The length of chromonic stacks is not fixed by covalent bonds and depends strongly on temperature, chromonic concentration, ionic content and pH of the solution. As a result, all these parameters can be used to control the assembly of NRs through the control of the linking agents. We also demonstrate that the process of NRs assembly can be quenched by adding a polyelectrolyte to the solution of NRs and chromonic material. The NR assemblies arrested by the polyelectrolyte can be transferred into a polymer film such as polyvinyl alcohol, preserving their structural and optical features.
Architectural aspects of automated network selection in heterogeneous wireless systems (2009)

Next-generation heterogeneous wireless systems using an all-IP transport allow converged services such as those based on IP Multimedia Subsystem (IMS) to be delivered over a variety of access technologies. These services however require underlying access technologies to support certain capabilities like Quality of Service. For devices supporting multiple access technologies this results in a complex problem of selection of an optimal service delivery access network. This paper addresses the architectural aspects of the problem by enhancing the roles of policy related components defined in cellular standards and by combining them with novel network selection components to enable automated network selection.
Comparison of different cardiovascular magnetic resonance sequences for native myocardial T1 mapping at 3T (2016)

"Canadian Alliance For Healthy Hearts and Minds" - ClinicalTrials.gov NCT02220582 ; registered August 18, 2014.
Inverse BEM Method to Identify Surface Temperatures and Heat Transfer Coefficient Distributions at Inaccessible Surfaces (2005)

The purpose of the inverse problem considered in this study is to resolve heat transfer coefficient distributions by solving a steady-state inverse problem. Temperature measurements at interior locations supply the additional information that renders the inverse problem solvable. A regularized quadratic functional is defined to measure the deviation of computed temperatures from the values under current estimates of the heat transfer coefficient distribution at the surface exposed to convective heat transfer. The inverse problem is solved by minimizing this functional using a parallelized genetic algorithm (PGA) as the minimization algorithm and a two-dimensional multi-region boundary element method (BEM) heat conduction code as the field variable solver. Results are presented for a regular rectangular geometry and an irregular geometry representative of a blade trailing edge and demonstrate the success of the approach in retrieving accurate heat transfer coefficient distributions.
Integrated AlGaInAs-silicon evanescent racetrack laser and photodetector (2008)

Recently, AlGaInAs-silicon evanescent lasers have been demonstrated as a method of integrating active photonic devices on a silicon based platform. This hybrid waveguide architecture consists of III-V quantum wells bonded to silicon waveguides. The self aligned optical mode leads to a bonding process that is manufacturable in high volumes. Here give an overview of a racetrack resonator laser integrated with two photo-detectors on the hybrid AlGaInAs-silicon evanescent device platform. Unlike previous demonstrations of hybrid AlGaInAs-silicon evanescent lasers, we demonstrate an on-chip racetrack resonator laser that does not rely on facet polishing and dicing in order to define the laser cavity. The laser runs continuous-wave (c.w.) at 1590 nm with a threshold of 175 mA, has a maximum total output power of 29 mW and a maximum operating temperature of 60 C. The output of this laser light is directly coupled into a pair of on chip hybrid AlGaInAs-silicon evanescent photodetectors used to measure the laser output.
Comparative Study of the Fire Behaviour of Glass-Fibre Reinforced Unsaturated Polyesters Using a Cone Calorimeter (1998)

This work deals with the fire behaviour of unsaturated polyester resin-based composites and with the influence of glass-fibre level on limiting oxygen index and oxygen consumption (in particular the rate of heat release). The combustion products are identified. 65 wt.% reinforcement allows reasonable FR properties using a first generation type resin.
An Algorithm for Obtaining Simplified Prime Implicant Sets in Fault-Tree and Event-Tree Analysis (1983)

Some fault trees or event trees use NOT logic in expressing an accident sequence. The number of prime implicant sets (PIS), a generalization of a minimal cut set and includes logical NOT as well as AND and OR, is apt to exceed general computer capacity. In order to deal with this problem, this paper assumes that component failure probability is far smaller than component success probability. Three steps are developed to delete certain sets of basic events from the fault tree of an accident sequence so as to obtain upper side approximate probability calculations and this with the number of PISs enumerated reduced to a practical level in most cases. Asymptotic convergence is proved and numerical examples are provided.
Current Progress and Challenges in HIV Gene Therapy (2011)

HIV-1 causes AIDS, a syndrome that affects millions of people globally. Existing HAART is efficient in slowing down disease progression but cannot eradicate the virus. Furthermore the severity of the side effects and the emergence of drug-resistant mutants call for better therapy. Gene therapy serves as an attractive alternative as it reconstitutes the immune system with HIV-resistant cells and could thereby provide a potential cure. The feasibility of this approach was first demonstrated with the 'Berlin patient', who was functionally cured from HIV/AIDS with undetectable HIV-1 viral load after transplantation of bone marrow harboring a naturally occurring CCR5 mutation that blocks viral entry. Here, we give an overview of the current status of HIV gene therapy and remaining challenges and obstacles.
Production and purification of active snowdrop lectin in Escherichia coli (1998)

Recombinant snowdrop lectin was produced in Escherichia coli from a cDNA clone encoding mature Galanthus nivalis agglutinin. After induction with isopropylthio-beta-D-galactoside, inclusion bodies from E. coli were solubilised and the G. nivalis agglutinin purified by metal-affinity chromatography using a carboxy-terminal hexahistidine tag. The protein was refolded on the metal-affinity column prior to elution. After purification, the recombinant G. nivalis agglutinin agglutinated rabbit erythrocytes to a dilution similar to that determined for 'native' lectin purified from snowdrop, and showed similar specific binding to mannose. The toxicity of the recombinant G. nivalis agglutinin towards rice brown planthopper (Nilaparvata lugens) was shown to be similar to that of 'native' G. nivalis agglutinin when incorporated into an artificial diet. The recombinant G. nivalis agglutinin is thus functionally similar to 'native' snowdrop lectin.
Brillouin-Based Random Fiber Optic Delay Line (2009)

A continuous-wave light as Brillouin probe is linearly frequency-modulated to determine the location of the delayed pulse signal via stimulated Brillouin scattering. The random ~4-μs continuous tunability is experimentally demonstrated. The pulse distortion is also studied.
S-Figure-5 from Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma (2023)

&lt;p&gt;In vitro treatment studies of murine Kras/p53 and Kras/p53/Lkb1 cell lines with 5FU or Pemetrexed&lt;/p&gt;
Time-multiplexed single front-end multiple-input multiple-output receivers with preserved diversity gain (2011)

A design technique to realise a low-complexity multiple-input multiple-output (MIMO) receiver using a time-multiplexed single front-end receiver is introduced. The architecture uses a simple front-end receiver where it delivers radio frequency signals to baseband section. The theory behind this architecture is analysed and the diversity gain of the proposed receiver is investigated. This simple MIMO receiver can provide the same diversity gain as the diversity gain of the multiple front-end. Moreover, the experimental studies are conducted to evaluate the diversity gain of the proposed architecture. Excellent agreement between the simulated and measurement results is obtained. The proposed architecture provides a new receiver design technique with lower complexity, power consumption and cost in MIMO systems.
Semiconductor based optical frequency comb source with optical linewidth &#x226A;1 kHz (2009)

A low noise, frequency stabilized, semiconductor based, 10.287 GHz actively mode-locked laser is reported with optical linewidth <1 kHz, optical frequency instability of ~150 kHz and integrated timing jitter (1 Hz-100 MHz) of 3fs.
A stochastic model of spatio-temporally correlated narrowband MIMO channel based on indoor measurement (2005)

We propose a spatio-temporal model for narrowband indoor non line of sight (NLOS) MIMO channel. The model bases on the parameterization from measured 8/spl times/4 MIMO radio channel. Validation of the model performance is made by comparing the estimated capacity and the temporal characteristic with these obtained from measurement. The results show that our model is capable of capturing the essential characteristics of a temporally correlated multipath MIMO radio channel.
A probe to new type jacquard technology of RJPC4F Jacquard raschel machine (2006)

RJPC4F Jacquard raschel machine for producing net curtain or ornamental fabrics is a new type fall plate Jacquard warp knitting machine. The products are widely used as curtain, tablecloth, scarf and other top grade net cloth. In this article are introduced the basic theory and jaquard technology of this Jacquard warp knitting machine in detail with characteristics of lapping movements in fabrics discussed.
Acceleration-snap feedforward scheme for a motion system with viscoelastic tuned-mass-damper (2017)

Bandwidth-limiting flexible modes in motion systems like the stage systems of a wafer scanner can effectively be damped by incorporating a viscoelastic tuned-mass-damper. This allows for an increase of bandwidth. The viscoelastic properties however pose a challenge on the feedforward design and thereby limit the achievable tracking performance. This is because the viscoelastic properties, which cannot be described by the simple addition of an elastic and a viscous element, induce a relaxation effect that prolongs well beyond the moment that inertial forces induced by the setpoint are being applied to the system. To cope with this problem, a tenth-order model fit from measured frequency response data that sufficiently captures the viscoelastic properties is combined with a data-based optimization approach needed to fine-tune a limited set of acceleration-snap feedforward gains. Experimental results from an industrial wafer stage system demonstrate the applicability of the approach.
Potentiating effect of glabridin from Glycyrrhiza glabra on GABA A receptors (2016)

Extracts from <i>Glycyrrhiza</i> are traditionally used for the treatment of insomnia and anxiety. Glabridin is one of the main flavonoid compounds from <i>Glycyrrhiza glabra</i> and displays a broad range of biological properties. In the present work, we investigated the effect of glabridin on GABA<sub>A</sub> receptors. For this purpose, we employed the two-electrode voltage-clamp technique on <i>Xenopus laevis</i> oocytes expressing recombinant GABA<sub>A</sub> receptors. Through this approach, we observed that glabridin presents a strong potentiating effect on GABA<sub>A</sub> α1β(1-3)γ2 receptors. The potentiation was slightly dependent on the β subunit and was most pronounced at the α1β2γ2 subunit combination, which forms the most abundant GABA<sub>A</sub> receptor in the CNS. Glabridin potentiated with an EC<sub>50</sub> of 6.3±1.7 µM and decreased the EC<sub>50</sub> of the receptor for GABA by approximately 12-fold. The potentiating effect of glabridin is flumazenil-insensitive and does not require the benzodiazepine binding site. Glabridin acts on the β subunit of GABA<sub>A</sub> receptors by a mechanism involving the M286 residue, which is a key amino acid at the binding site for general anesthetics, such as propofol and etomidate. Our results demonstrate that GABA<sub>A</sub> receptors are strongly potentiated by one of the main flavonoid compounds from <i>Glycyrrhiza glabra</i> and suggest that glabridin could contribute to the reported hypnotic effect of <i>Glycyrrhiza</i> extracts.
3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity (1995)

The substitution of aspartate at position 153 in Escherichia coli alkaline phosphatase by glycine results in a mutant enzyme with 5-fold higher catalytic activity (kcat) but no change in Km at pH 8.0 in 50 mM Tris-HCl. The increased kcat is achieved by a faster release of the phosphate product as a result of the lower phosphate affinity. The mutation also affects Mg2+ binding, resulting in an enzyme with lower metal affinity. The 3-D X-ray structure of the D153G mutant has been refined at 2.5 A to a crystallographic R-factor of 16.2%. An analysis of this structure has revealed that the decreased phosphate affinity is caused by an apparent increase in flexibility of the guanidinium side chain of Arg166 involved in phosphate binding. The mutation of Asp153 to Gly also affects the position of the water ligands of Mg2+, and the loop Gln152-Thr155 is shifted by 0.3 A away from the active site. The weaker Mg2+ binding of the mutant compared with the wild type is caused by an altered coordination sphere in the proximity of the Mg2+ ion, and also by the loss of an electrostatic interaction (Mg2+.COO-Asp153) in the mutant. Its ligands W454 and W455 and hydroxyl of Thr155, involved in the octahedral coordination of the Mg2+ ion, are further apart in the mutant compared with the wild type.
If WiFi APs Could Move: A Measurement Study (2018)

This paper explores the possibility of injecting mobility into wireless network infrastructure. We envision WiFi APs on wheels that move to optimize user performance. Movements need not be all around the floor, neither do they have to operate on batteries. As a first step, WiFi APs at home could remain tethered to power and Ethernet outlets while moving in small areas (perhaps under the couch). If such systems prove successful, perhaps future buildings could offer explicit support for network infrastructure mobility. This paper begins with a higher level discussion of robotic wireless networks-the opportunities and the hurdles-and then pivots by developing a smaller slice of the vision through a system called iMob. With iMob, a WiFi AP is mounted on a Roomba robot and made to periodically move within a 2x2 sqft region. The core questions pertain to finding the best location to move to, such that the SNRs from its clients are strong, and the interferences from other APs are weak. Our measurements show that the richness of wireless multipath offers significant opportunities-even within a 2x2 sqft region, locations exist that are 1:7x better than the average location in terms of throughput. When multiple APs in a neighborhood coordinate, the gains can be even higher. In sum, although infrastructure mobility has been discussed in the context of Google Balloons, ad hoc networks, and delay tolerant networks, we believe that the possibility of moving our personal devices in homes and offices is relatively unexplored, and could open doors to new kinds of innovation.
Batch and semicontinuous emulsion copolymerization of vinylidene chloride and butyl methacrylate. I. Kinetics in VDC–BMA emulsion polymerization and surface and colloidal properties of VDC–BMA latexes (1992)

Abstract Vinylidene chloride (VDC)—butyl methacrylate (BMA) comonomer mixtures with various composition (83 : 17, 60 : 40, 33 : 67 in mol %) were polymerized at 25°C using redox catalyst by batch and seeded semicontinuous emulsion copolymerization. The reactivity ratios determined in VDC ( M 1 )—BMA ( M 2 ) emulsion copolymerization system were r 1 = 0.22 and r 2 = 2.41. Seven 35% solids (83 : 17 mol %) VDC–BMA copolymer latexes were prepared: one batch (G), one seeded batch (F), and 5 seeded semicontinuous polymerizations of 5 different monomer feed rates ranging from 0.27 (A) to 1.10 wt %/min (E). The kinetic studies of seeded semicontinuous polymerizations A‐E showed that the rates of polymerizations ( R p ) were controlled by the monomer addition rates ( R a ). The conversion versus time curves for the polymerizations of 0 : 100–100 : 0 VDC–BMA mixtures by batch polymerization showed that the rate of polymerization ( R p ) was a function of the number of particles, and that the rate of polymerization in a latex particle ( R pp ) increased with increasing proportions of butyl methacrylate in the monomer mixture. All of the latexes had narrow particle size distributions. The greater particle number density in VDC polymerization and the greater water solubility of VDC suggest that the homogeneous nucleation mechanism is operative in VDC–BMA copolymerizations. The latex copolymers prepared by semicontinuous polymerization had lower number‐and weight‐average molecular weights than those of the corresponding batch copolymers, resulting from the monomer starvation occurring during the semicontinuous polymerization. The surface characterization study of the cleaned latexes showed that for the latexes by batch process, the surface charge density derived from strong‐acid groups decreased with increasing proportion of VDC in the monomer mixture. On the other hand, for the latexes prepared by semicontinuous polymerization, the surface charge density derived from strong‐acid groups did not depend on the monomer composition of the copolymers.
Microscopic colitis: a review (2002)

Microscopic colitis is a relatively common cause of chronic watery diarrhea, often accompanied by abdominal pain and weight loss. The colonic mucosa appears normal grossly, and the diagnosis is made when there is an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. Many potential pathophysiological mechanisms have been described, although none have been conclusively proved. There is a paucity of randomized treatment trials in these patients, although a rational approach to therapy often leads to satisfactory control of symptoms.
Instrument development for a toxic level hypergolic vapor detector (1980)

The development and deployment of technology applicable to the field measurement of hypergolic propellants is discussed. The propellants include hydrazine (H) monomethylhydrazine (MMH), and 1,1-dimethylhydrazine (UDMH) at the parts per billion (PPB) level in air or a diluent gas. Four major areas are reviewed: (1) development of an improved electrochemical sensor for the measurement of hydrazines (H, MMH and UDMH) in air; (2) prototype instrument fabrication and subsequent laboratory evaluation; (3) initial instrument field test results; and (4) future requirements and applications.
Spinal neuroplasticity in chronic pain (2011)

Abstract Neuroplastic changes play an important role in the generation and maintenance of chronic pain syndromes. Such changes occur at all levels of the neuraxis, from the peripheral terminals of primary sensory neurons to the cerebral cortex. Changes observed in the spinal dorsal horn in particular provide a mechanistic basis for many of the characteristics of chronic pain syndromes. While facilitated synaptic transmission between nociceptive fibers and spinal projection neurons contributes to enhanced perception of noxious stim­uli (hyperalgesia), diminished function of GA­BA-ergic and glycinergic interneurons not only induces hyperalgesia, but also triggers no­ciceptive reactions on exposure to innocuous stimuli and spontaneous pain behavior in the absence of any sensory stimulation. Spinal disinhibition thus recapitulates typical symptoms of chronic pathological pain syndromes. Studies performed by various groups over the last 10 years demonstrate that such spinal disinhibition occurs naturally in response to peripheral inflammation and nerve dam­age. The present article summarizes current status of this research.
Micromechanics of High-Strength, High-Ductility Concrete (2013)

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