gebhart/patrepeval huggingface dataset:
Photon catalysis of deuterium iodide photodissociation (2018)

A catalyst enhances a reaction pathway without itself being consumed or changed. Recently, there has been growing interest in the concept of "photon catalysis" in which nonresonant photons, which are neither absorbed nor scattered, promote reactions. The driving force behind this effect is the interaction between the strong electric field associated with a pulsed, focused laser and the polarizability of the reacting system. In this study, the effect of near-infrared, nonresonant radiation on the photodissociation of deuterium iodide is demonstrated. We use nanosecond pulses rather than time-resolved spectroscopy to investigate the average effect of the electric field on the branching ratio for forming D + I(<sup>2</sup>P<sub>3/2</sub>) and D + I(<sup>2</sup>P<sub>1/2</sub>). Changes in the measured D-atom speeds between field-free and strong-field conditions confirm substantial differences in dissociation dynamics. Both the magnitude and direction of change in the branching ratios are dependent upon the photodissociation wavelength. Experiments and theoretical calculations confirm that the mechanism for photon catalysis under these conditions is dynamic Stark shifting of potential energy surfaces rather than electric-field-induced alignment of reagent molecules.
Thermal Conductivity of Self-Reinforced Silicon Nitride Containing Large Grains Aligned by Extrusion Pressing (1997)

β-Si3N4 containing 0.5mol%Y2O3 and 0.5mol%Nd2O3 was seeded with 5mass% β-Si3N4 whisker with high aspect ratio and extruded to align the whiskers. Self-reinforced microstructure composed of well-aligned large elongated grains in smaller matrix grains was developed by the grain growth of seeded whiskers during gas-pressure sintering at 2000°C in 30MPa N2 for 4h and heat treatment at 2200°C in 30MPa N2 for 4h. Room-temperature thermal conductivity was anisotropic; 140W·m-1·K-1 for parallel to the grain alignment, and 84W·m-1·K-1 for perpendicular to the alignment.
In vitro reconstitution of human kidney structures for renal failure (2009)

Guimaraes-Souza, Nadia MD, PhD; Aboushwareb, Tamer MD; Stern, Kathryn PhD; Atala, Anthony MD, FACS; Yoo, James MD, PhD Author Information
Multiphoton Sub-Band-Gap Photoconductivity and Critical Transition Temperature in Type-II GaSb Quantum-Dot Intermediate-Band Solar Cells (2014)

Quantum dots can provide electronic states that act as ``stepping stones'' in absorbing light, thereby improving the efficiency of solar cells. The authors identify a transition temperature at which a significant gain in solar energy absorption is seen in GaSb/GaAs quantum dots, and show that this gain is due to a particular alignment of bands in the underlying electronic structure. Related behaviors could also be valuable in optoelectronics and quantum information processing.
Applications for direct light triggered thyristors with integrated protection functions (2003)

Direct light triggered thyristors (LTT) were developed for high voltage direct current transmission (HVDC) applications, because of the considerable advantage of high voltage blocking and the easy way of light triggering. Several protection functions were integrated in the LTT which are normally installed around the electrical triggered thyristor (ETT) by expensive and sensitive electronic components. LTTs are in use in applications with high voltage where a series connection of thyristors is necessary. For example HVDC, static VAr compensation (SVC), converters for medium voltage drives, and several pulse power applications.
Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines (1999)

We have identified an amino acid sequence, termed peptide 3, corresponding to amino acids 51-62 of the mature human monocyte chemoattractant protein-1 (MCP-1), which inhibits human mononuclear-cell and THP-1-cell migration induced by a wide range of chemokines. For example, peptide 3 inhibited MCP-1-induced THP-1 migration in a transwell assay with an ED50 of approx. 8 microM. Peptide 3 binds directly to THP-1 cells with an association constant of approx. 10 microM, and is therefore likely to be a direct receptor antagonist for CC and CXC chemokine receptors. By performing a structure-function analysis of this peptide, we have identified a sequence variant that shows an approx. 3-4-fold greater potency as an inhibitor of chemokine-induced migration [Leu4Ile11 peptide 3 (1-12)]. Furthermore, unlike peptide 3, which binds to the Duffy antigen receptor for chemokines on human erythrocytes with a similar affinity to the specific chemokine receptors on THP-1 cells, the Leu4Ile11 peptide 3 (1-12) sequence variant shows at least 20-fold greater selectivity for the specific receptors. Derivatives of Leu4Ile11 peptide 3 (1-12) are therefore the best candidates among the molecules we have investigated for use as a chemokine inhibitor in vivo.
21.3: Invited Paper: Latest Development of “System‐on‐Glass” Display with Low Temperature Poly‐Si TFT (2004)

Abstract A 2.3‐inch diagonal, QVGA formatted “System‐on‐glass” display has been developed by low temperature poly‐Si TFT LCD technology. This display fully integrates 6‐bit RGB digital interface drivers as well as all the power‐supply circuitry to drive the LCD, which requires neither external ICs nor power supply ICs. This paper discusses the newly developed TFT circuit technologies used in this LCD. The development trend in the “System‐on‐glass” display is also reviewed.
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia (2021)

Red blood cells detect and bind cell-free nucleic acids, contributing to anemia and immune cell activation during acute inflammation.
Frequency dependence of microflows upon acoustic interactions with fluids (2017)

Rayleigh surface acoustic waves (SAWs), generated on piezoelectric substrates, can interact with liquids to generate fast streaming flows. Although studied extensively, mainly phenomenologically, the effect of the SAW frequency on streaming in fluids in constrained volumes is not fully understood, resulting in sub-optimal correlations between models and experimental observations. Using microfluidic structures to reproducibly define the fluid volume, we use recent advances modeling the body force generated by SAWs to develop a deeper understanding of the effect of acoustic frequency on the magnitude of streaming flows. We implement this as a new predictive tool using a finite element model of fluid motion to establish optimized conditions for streaming. The model is corroborated experimentally over a range of different acoustic excitation frequencies enabling us to validate a design tool, linking microfluidic channel dimensions with frequencies and streaming efficiencies. We show that in typical microfluidic chambers, the length and height of the chamber are critical in determining the optimum frequency, with smaller geometries requiring higher frequencies.
Cavity-enhanced single photons from a quantum dot (Invited Paper) (2005)

Single-photon sources rarely emit two or more photons in the same pulse, compared to a Poisson-distributed source of the same intensity, and have numerous applications in quantum information science. The quality of such a source is evaluated based on three criteria: high efficiency, small multi-photon probability, and quantum indistinguishability. We have demonstrated a single-photon source based on a quantum dot in a micropost microcavity that exhibits a large Purcell factor together with a small multi-photon probability. For a quantum dot on resonance with the cavity, the spontaneous emission rate has been increased by a factor of five, while the probability to emit two or more photons in the same pulse has been reduced to 2% compared to a Poisson-distributed source of the same intensity. The indistinguishability of emitted single photons from one of our devices has been tested through a Hong-Ou-Mandel-type two-photon interference experiment; consecutive photons emitted from such a source have been largely indistinguishable, with a mean wave-packet overlap as large as 0.81. We have also designed and demonstrated two-dimensional photonic crystal GaAs cavities containing InAs quantum dots that exhibit much higher quality factors together with much smaller mode volumes than microposts, and therefore present an ideal platform for construction of single photon sources of even higher quality.
Use of paravascular admittance waveforms to monitor relative change in arterial blood pressure (2010)

Non-invasive methods to monitor ambulatory blood pressure often have limitations that can affect measurement accuracy and patient adherence [1]. Minimally invasive measurement of a relative blood pressure surrogate with an implantable device may provide a useful chronic diagnostic and monitoring tool. We assessed a technique that uses electrocardiogram and paravascular admittance waveform morphology analysis to one, measure a time duration (vascular tone index, VTI in milliseconds) change from the electrocardiogram R-wave to admittance waveform peak and two, measure the admittance waveform minimum, maximum and magnitude as indicators of change in arterial compliance/distensibility or pulse pressure secondary to change in afterload. Methods: Five anesthetized domestic pigs (32 ± 4.2 kg) were used to study the effects of phenylephrine (1-5 ug/kg/min) on femoral artery pressure and admittance waveform morphology measured with a quadrapolar electrode array catheter placed next to the femoral artery to assess the relative change in arterial compliance due to change in peripheral vascular tone. Results: Statistical difference was observed (p < 0.05) comparing baseline VTI to phenylephrine VTI (246 ± .05 ms to 320 ± .07 ms) and baseline admittance waveform maximum to phenylephrine admittance waveform maximum (0.0148 ± .002 siemens to 0.0151 ± .002 siemens). Conclusion: Chronic minimally invasive admittance measurement techniques that monitor relative change in blood pressure may be suitable for implantable devices to detect progression of cardiovascular disease such as hypertension.
Moraxella Catarrhalis : From Interactions with the Host Immune System to Vaccine Development (2012)

Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection.
Two Wavelength Photorefractive Dynamic Optical Interconnect (1988)

A novel switch geometry using photorefractive crystals has been demonstrated which has nondestructive readout and reduces the order of complexity of a non-blocking switching network. It is a routing full duplex design capable of handling the full bandwidth of the input signals. It is fully reconfigurable in times which depend principally upon the photorefractive material used and the intensity of the writing beams. The concept is applicable for use with a variety of photorefractive materials. The capacity of this switch has been calculated to be on the order of 100, based upon the sum of inputs and outputs, but is primarily limited by its simultaneous interconnectability. This limit is set by the number of gratings which can be stored in a single photorefractive crystal at one time. A demonstration of a 2 x 3 switch using BGO with 514nm writing beams and 633nm signal (readout) beams is descibed.
Will Distributed Computing Revolutionize Peace? The Emergence of Battlefield IoT (2018)

An upcoming frontier for distributed computing might literally save lives in future military operations. In civilian scenarios, significant efficiencies were gained from interconnecting devices into networked services and applications that automate much of everyday life from smart homes to intelligent transportation. The ecosystem of such applications and services is collectively called the Internet of Things (IoT). Can similar benefits be gained in a military context by developing an IoT for the battlefield? This paper describes unique challenges in such a context as well as potential risks, mitigation strategies, and benefits.
Design of a liquid cell toward three-dimensional imaging of unidirectionally-aligned particles in solution using X-ray free-electron lasers (2019)

X-ray free-electron lasers (XFELs) opened up a possibility for molecular-scale single particle imaging (SPI) without the need for crystallization. In SPI experiments, the orientation of each particle has to be determined from the measured diffraction pattern. Preparing unidirectionally-aligned particles can facilitate the determination of the sample orientation. Here, we show the design principles of a liquid cell for three-dimensional imaging of unidirectionally-aligned particles in solution with XFELs. The liquid cell was designed so that neither incident X-rays nor diffracted X-rays are blocked by the substrate of the liquid cell even at high tilt angles. As a feasibility evaluation, we performed coherent diffraction measurements using the cells with a 1 μm focused XFEL beam. We successfully measured coherent diffraction patterns of a nano-fabricated metal pattern at 70° tilt angle and obtained the reconstructed image by applying iterative phase retrieval. The liquid cell will be usefully applied to molecular-scale SPI by using more tightly focused XFELs. In particular, imaging of membrane proteins embedded in lipid membranes is expected to have an enormous impact on life science and medicine.
Insulin-stimulated cell growth in insulin receptor substrate-1–deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase–independent pathway (1998)

In many human breast cancers and cultured cell lines, insulin receptor expression is elevated, and insulin, via its own insulin receptor, can stimulate cell growth. It has recently been demonstrated that the enzyme phosphatidylinositol-3-kinase (PI3-K) mediates various aspects of insulin receptor signaling including cell growth. In order to understand the mechanisms for insulin-stimulated cell growth in human breast cancer, we measured insulin-stimulable PI3-K activity in a non-transformed breast epithelial cell line, MCF-10A, and in two malignantly transformed cell lines, ZR-75-1 and MDA-MB157. All three cell lines express comparable amounts of insulin receptors whose tyrosine autophosphorylation is increased by insulin, and in these cell lines insulin stimulates growth. In MDA-MB157 and MCF-10A cells, insulin stimulated PI3-K activity three- to fourfold. In ZR-75-1 cells, however, insulin did not stimulate PI3-K activity. In ZR-75-1 cells PI3-K protein was present, and its activity was stimulated by epidermal growth factor, suggesting that there might be a defect in insulin receptor signaling upstream of PI3-K and downstream of the insulin receptor. Next, we studied insulin receptor substrate-1 (IRS-1), a major endogenous substrate for the insulin receptor which, when tyrosine is phosphorylated by the insulin receptor, interacts with and activates PI3-K. In ZR-75-1 cells, there were reduced levels of protein for IRS-1. In these cells, both Shc tyrosine phosphorylation and mitogen-activated protein kinase (MAP-K) activity were increased by the insulin receptor (indicating that the p21ras pathway may account for insulin-stimulated cell growth in ZR-75-1 cells). The PI3-K inhibitor LY294002 (50 microM) reduced insulin-stimulated growth in MCF-10A and MDA-MB157 cell lines, whereas it did not modify insulin effect on ZR-75-1 cell growth. The MAP-K/Erk (MEK) inhibitor PD98059 (50 microM) consistently reduced insulin-dependent growth in all three cell lines. Taken together, these data suggest that in breast cancer cells insulin may stimulate cell growth via PI3-K-dependent or-independent pathways.
mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer (2019)

MTOR associated protein, eak-7 homolog (mEAK-7), activates mechanistic target of rapamycin (mTOR) signaling in human cells through an alternative mTOR complex to regulate S6K2 and 4E-BP1. However, the role of mEAK-7 in human cancer has not yet been identified. We demonstrate that mEAK-7 and mTOR signaling are strongly elevated in tumor and metastatic lymph nodes of patients with non-small-cell lung carcinoma compared with those of patients with normal lung or lymph tissue. Cancer stem cells, CD44+/CD90+ cells, yield elevated mEAK-7 and activated mTOR signaling. mEAK-7 is required for clonogenic potential and spheroid formation. mEAK-7 associates with DNA-dependent protein kinase catalytic subunit isoform 1 (DNA-PKcs), and this interaction is increased in response to X-ray irradiation to regulate S6K2 signaling. DNA-PKcs pharmacologic inhibition or genetic knockout reduced S6K2, mEAK-7, and mTOR binding with DNA-PKcs, resulting in loss of S6K2 activity and mTOR signaling. Therefore, mEAK-7 forms an alternative mTOR complex with DNA-PKcs to regulate S6K2 in human cancer cells.
Higher Order Geometric Theory of Information and Heat based on Poly-Symplectic Geometry of Souriau Lie Groups Thermodynamics and Their Contextures (2018)

We introduce poly-symplectic extension of Souriau Lie groups Thermodynamics based on higher-order model of statistical physics introduced by R.S. Ingarden. This extended model could be used for small data analytics and Machine Learning on Lie groups. Souriau Geometric Theory of Heat is well adapted to describe density of probability (Maximum Entropy Gibbs density) of data living on groups or on homogeneous manifolds. For Small Data Analytics (Rarified Gases , sparse statistical survey,…), density of maximum entropy should consider Higher Order Moments constraints (Gibbs density is not only defined by first moment but fluctuations request 2nd order and higher moments) as introduced by R.S. Ingarden. We use Poly-sympletic model introduced by Christian Günther, replacing the symplectic form by a vector-valued form. The poly-symplectic approach generalizes the Noether theorem, the existence of momentum mappings, the Lie algebra structure of the space of currents, the (non-)equivariant cohomology and the classification of G-homogeneous systems. The formalism is covariant, i.e. no special coordinates or coordinate systems on the parameter space are used to construct the Hamiltonian equations. We underline the contextures of these models, and the process to build these generic structures.
A double-crystal X-ray spectrometer stabilised by a dynamic feedback system (1979)

The stabilisation of a double-crystal spectrometer in a (+n, -n) position is described. A long-term angular drift of less than 0.02" has been obtained by means of a dynamic feedback system. This system has been especially devised for controlling the angle between the reflecting planes of the first and second crystal and thereby the position of the nodal planes of a standing-wave field created in perfect single crystals such as silicon.
Compact Electro-Mechanical-Fluidic Model for Actuated Fluid Flow System (2017)

This paper presents a compact electro-mechanical-fluidic system-modeling method for multidomain system simulation based on multidomain physics that considers the total energy conservation condition, in terms of respective potential and flow quantities. Models for electrical, mechanical, and fluidic domains are developed to design the example of a blood pumping system, where the blood flow is driven by electrically controlled organic actuators. The electrical domain includes an organic mosfet-based control circuit, the mechanical domain includes organic actuators, and the fluidic domain includes a flexible fluid-flow channel. Control circuit, actuators, and fluid models are coupled through equivalent circuits, where interconnection relationships between two neighboring domains are expressed using the energy conservation concept. The model accuracy is verified with finite element method (FEM) based numerical simulation. Significantly faster simulation speed than with FEM and good accuracy were achieved.
Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons (2002)

The structure of the complex formed between d(CGTACG)2 and 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide, an inactive derivative of the antitumour agents N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 9-amino-DACA, has been solved to a resolution of 1.8 A using X-ray crystallography. The complex crystallises in the space group P6(4 )and the final structure has an overall R factor of 21.9%. A drug molecule intercalates between each of the CpG dinucleotide steps with its side chain lying in the major groove, and its protonated morpholino nitrogen partially occupying positions close to the N7 and O6 atoms of guanine G2. The morpholino group is disordered, the major conformer adopting a twisted boat conformation that makes van der Waals contact with the O4 oxygen of thymine T3. A water molecule forms bridging hydrogen bonds between the 4-carboxamide NH and the phosphate group of guanine G2. Sugar rings are found in alternating C3'-exo/C2'-endo conformations except for cytosine C1 which is C3'-endo. Intercalation perturbs helix winding throughout the hexanucleotide compared with B-DNA, steps 1 and 2 being unwound by 10 and 8 degrees, respectively, while the central TpA step is overwound by 11 degrees. An additional drug molecule lies at the end of each DNA helix linking it to the next duplex to form a continuously stacked structure. The protonated morpholino nitrogen of this 'end-stacked' drug hydrogen bonds to the N7 atom of guanine G6, and its conformationally disordered morpholino ring forms a C-H...O hydrogen bond with the guanine O6 oxygen. In both drug molecules the 4-carboxamide group is internally hydrogen bonded to the protonated N10 atom of the acridine ring. We discuss our findings with respect to the potential role played by the interaction of the drug side chain and the topoisomerase II protein in the poisoning of topoisomerase activity by the acridinecarboxamides.