gebhart/patrepeval huggingface dataset:
A High Performance Massively Parallel Approach for Real Time Deformable Body Physics Simulation (2008)

Single processor technology has been evolving across last decades, but due to physical limitations of chip manufacturing process, the industry is pursuing alternatives to sustain computational power growth,including the creation of multi-core systems. Parallel computing targets problems that are scalable and possibly distributed, dividing the problem into smaller pieces. This approach may be explored to satisfy real-time constraints required by real time physics simulation. This work introduces an optimal solution to implement accurate simulation of deformable bodies in real time. This is accomplished through the use of a meshless simulation technique, known as Point Based Animation, implemented using a parallel framework:the NVIDIA Compute Unified Device Architecture(CUDA). Our implementation showed significative improvements on performance in comparison to the former CPU one: impressive speedups around 20times could be achieved in the simulation of deformable bodies with 575 physical elements (phyxels) and53,504 surface elements (surfels).
Nitroxide-mediated miniemulsion polymerization ofn-butyl acrylate: synthesis of controlled homopolymers and gradient copolymers with styrene (2002)

Controlled free-radical homopolymerization of n-butyl acrylate and its copolymerization with styrene have been studied in aqueous miniemulsion, using an acyclic β-phosphonylated nitroxide as a mediator, the N-tert-butyl-N-(1-diethylphosphono-2,2-dimethylpropyl) nitroxide, also called SG1. Polymerization kinetics have been studied and characterization of the (co)polymers has been performed, demonstrating the successful synthesis of well-defined poly(n-butyl acrylate) homopolymers and poly(n-butyl acrylate-co-styrene) gradient copolymers.
Approximation Techniques for Broad-Band Acoustic Radiated Noise Design Optimization Problems (1995)

This study investigates the applicability of various approximation methods to broadband radiated noise design optimization problems. Low-order series approximations of dynamic response may be used to replace full numerical system solutions to effect significant computer cost savings during design iterations. Also, the ease of evaluating the approximate functions may be further exploited by using global optimization search methods, such as simulated annealing, at individual design iterations. The combination of approximating radiated noise spectra and evaluating the approximate spectra for all possible design alternatives greatly increases the possibility of finding a truly optimal design. The effectiveness of the approximations is measured by considering optimization accuracy, evaluated by the algorithm’s ability to find a global or near-global minimum independent of the initial design; computational efficiency, based on the number of numerical design analyses required for convergence; and generality, where the method should be relatively independent of the problem type. Finite element models of three test cases with varying performance goals and design parameters were used to evaluate the optimization methods. Shell thicknesses, shell loss factors, and rib stiffener locations were varied to minimize structural weight and manufacturing costs while lowering broad-band radiated noise levels below a specified goal. First-order Taylor and half-quadratic series approximation optimization approaches were compared to traditional local minimization methods (Modified Method of Feasible Directions and Broydon-Fletcher-Goldfarb-Shanno). For all test cases, the approximation approaches found the global optimum design more frequently than the local minimization methods. Also, the half-quadratic method converged using fewer design evaluations than the first-order Taylor method for most test cases.
Resistivity Distribution in Undoped 6H-SiC Boules and Wafers (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Figure S2 from Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer (2023)

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The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. (1998)

Chemokines are widely hypothesized to stimulate firm adhesion of leukocytes on endothelium in shear flow. Thus far, this has been demonstrated experimentally for exogenously added chemoattractants, but not for those released by endothelium. We found that human umbilical cord endothelial cells (HUVEC) stimulated with TNF-alpha and IFN-gamma secreted eosinophil chemoattractants into the culture supernatant. This material induced transendothelial chemotaxis, stimulated eosinophil binding to purified intercellular adhesion molecule 1, and augmented binding to purified vascular cell adhesion molecule 1 in a 3-min static assay. Chemotaxis and stimulation of adhesion were abrogated completely by the pretreatment of eosinophils with an mAb to the C-C chemokine receptor 3 (CCR3). Eosinophils accumulated efficiently on HUVEC stimulated with TNF-alpha and IFN-gamma in shear flow at 1.5 dyn/cm2. CCR3 mAb slightly but significantly reduced eosinophil arrest and accumulation, by preventing development of firm adhesion by some of the tethered eosinophils, so that they detached within 30 s after the initial tethering. In the presence of mAb to the alpha4 integrin subunit, the effect of CCR3 mAb was more prominent, and approximately half of eosinophil arrest and accumulation was abolished. Inhibition by CCR3 mAb in the presence of beta2 integrin mAb was similar to that in control eosinophils. This is the first evidence that endothelial cell-derived chemokines can activate firm adhesion through alpha4 and beta2 integrins even in the presence of shear flow.
Guest editorial special issue on computational intelligence in telecommunications networks and internet services-part I (2003)

In recent years, we have witnessed a rapidly growing role of the Internet that has already formed a conceptual backbone of the society in the information era. What becomes apparent and highly visible is a broad range of services and their enormous diversity being seamlessly available to those surfing cyberspace. The ongoing developments not only have enabled a different way of doing business but also pushed toward ambient intelligence where the user fully interacts with his or her surrounding information environment. The three special issues bring together the ideas of CI to the network area in a systematic, coherent, and comprehensive fashion that will help us move one step closer to the realization of the vision of ambient intelligence.
Composite planar double-sided AMC surfaces for MIMO applications (2009)

Increasing consumer demand for additional and more capable wireless and high-speed data services has led to many new wideband and multiband communications devices. Multiple-input multiple-output (MIMO) antenna systems are one such technology that can increase data rates, provide robustness and reduce interference. However, mutual coupling issues can arise from having multiple antennas in compact and mobile MIMO devices. For reduced mutual coupling, antennas are typically spaced at a minimum of lambda/2 apart . If a separator such as a standard metal sheet is placed in between two antennas to reduce coupling, each must be at least lambda/4 away from the screen for proper operation. However, from image theory it is known that antennas can efficiently work in close proximity (less than lambda/4) when placed over a magnetically conducting surface. A new design technique is introduced here for creating thin, double-sided artificial magnetic conductor screens for isolation of two closely placed antennas. Doubly periodic thin surfaces with electrically small unit cells are designed and optimized using a genetic algorithm (GA). A practical example using closely spaced monopole antennas is created and verified using Ansoft HFSStrade.
Characterization Of The S' Subsite Specificity Of Trypsin (1987)

The S' subsite specificity of bovine trypsin has been studied by partitioning of o-nitrophenylsulfenyl-L-arginyl-trypsin (formed using o-nitrophenylsulfenyl-L-arginine alkyl esters as acyl donors) between various amino acid-derived nucleophiles and water. The data obtained from spectrophotometric measurements confirmed a preference of trypsin for arginine residues in the P'1-position, which is less marked but quite similar to that of chymotrypsin. The amides of leucine, phenylalanine, methionine, threonine, lysine and valine are better for synthesis than the corresponding methyl esters, and show a moderate nucleophile efficiency, decreasing in that order. Amides of acidic amino acids and D-leucine were ineffective in forming the peptide bond, whereas norvaline amide and dipeptide amides lead to increased aminolysis.
Towards In-Circuit Tuning of Deep Learning Designs (2019)

This paper presents InTune, a novel approach for in-circuit tuning of deep learning designs targeting implementations in field-programmable gate array technology. This approach combines two promising techniques: domain-specific adaptation and in-circuit tuning. Domain-specific adaptation exploits domain-specific information in adapting pre-trained models to specific application domains, replacing standard convolution layers with efficient convolution blocks; the effects of such adaptation are then assessed by in-circuit tuning instruments to provide information to application builders for tuning the design. This approach is illustrated by its deployment in tuning deep neural networks, and its potential for a new generation of domain-specific tools with tight integration of synthesis and in-circuit tuning is explored.
Passive monolithic microwave multisensor based on N coupled Substrate Integrated resonators for environmental detection (2016)

This work presents a novel fully passive monolithic microwave multisensor on Substrate Integrated Waveguide (SIW) technology for simultaneous detection of humidity and temperature. The proposed structure is simple and combines several resonators with well controlled coupling. Each resonator of the multisensor is capable of environmental detection. The detection principle is based on a frequency shift due to a perturbation of the effective permittivity, depending on the sensitivity of the dielectric medium to the surrounding physical variable. The presented multisensor structure operates in the frequency range from 5-9.5 GHz and exhibits a frequency shift for relative humidity in the range of 6.5-93%RH and for temperature between 23-60°C. Based on SIW technology, this new monolithic environmental solution presents the advantage of being easily integrated into planar structure, energetically efficient and low-cost for mass production application.
Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors (2010)

Abstract The histone deacetylase (HDAC) metalloenzymes are intricately involved in gene expression through epigenetic regulation of histone acetylation. They also regulate the acetylation status of numerous non-histone proteins such as transcription factors p53, STAT1 and NF-κB as well as α-tubulin, Hsp90 and Ku70. Of the eleven zinc-dependent HDAC enzymes identified, HDACs 1 and 2 appear to be most critical in oncogenesis and tumor maintenance. They are overexpressed in many human cancers and RNAi knockdown leads to increased apoptosis. We recently disclosed a family of novel HDAC1/HDAC2-selective biaryl inhibitors. In this presentation, we will describe unique features of these biaryl inhibitors that contribute to improved preclinical efficacy and tolerability. Desirable HDAC inhibitor properties identified from preclinical experience with Zolinza™ include subtype selectivity toward HDAC1/HDAC2 and prolonged target inhibition. Compelling in vitro and in vivo data indicates that solid tumor cell lines are most sensitive to HDAC inhibition under continuous exposure rather than intermittent exposure. These biaryl inhibitors exhibit extended target engagement in vivo, and are well tolerated in nude mice. Unlike other known HDAC inhibitors, these compounds exhibit a delay in and prolongation of histone hyperacetylation in nude mice bearing HCT116 tumors, extending beyond plasma clearance of the drug. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5433.
Position‐ and Orientation‐Controlled Growth of Wulff‐Shaped Colloidal Crystals Engineered with DNA (2020)

Colloidal crystals have emerged as promising candidates for building optical microdevices. Techniques now exist for synthesizing them with control over their nanoscale features (e.g., particle compositions, sizes, shapes, and lattice parameters and symmetry); however, the ability to tune macroscale structural features, such as the relative positions of crystals to one another and lattice orientations, has yet to be realized. Here, inspiration is drawn from epitaxial growth strategies in atomic crystallization, and patterned substrates are prepared that, when used in conjunction with DNA-mediated nanoparticle crystallization, allow for control over individual Wulff-shaped crystal growth, location, and orientation. In addition, the approach allows exquisite control over the patterned substrate/crystal lattice mismatch, something not yet realized for any epitaxy process. This level of structural control is a significant step toward realizing complex, integrated devices with colloidal crystal components, and this approach provides a model system for further exploration in epitaxy systems.
Multifunctional Hybrid Silica Nanoparticles with a Fluorescent Core and Active Targeting Shell for Fluorescence Imaging Biodiagnostic Applications (2015)

Abstract We prepared hybrid nanoparticles with a brightly fluorescent silica core and a biocompatible thermoresponsive polymer shell containing tumor‐targeting folic acid (FA) groups. The silica core has a perylenediimide fluorescent dye anchored covalently to the structure for traceability and bioimaging applications. The polymeric shell was synthesized by reversible addition–fragmentation chain‐transfer (RAFT) polymerization to guarantee the homogeneous size of the particle shell. The shell is composed of copolymer chains with one block of oligo(ethylene glycol)methacrylate and 2‐(2′‐methoxyethoxy)ethylmethacrylate with another block of the reactive monomer N ‐acryloxysuccinimide (NAS). The NAS groups were used to covalently attach a large amount of amino‐functionalized FA to the particle shells to provide active targeting properties towards cancer cells and tissues. The targeting capability of the folate‐containing nanoparticles was evaluated against NCI‐H460 tumor cells, which overexpress folate receptors. The nanoparticles with FA show a higher uptake efficiency compared to that of the equivalent nanoparticles without FA. This result validates the imaging capabilities and active targeting efficiency of our nanoparticles, an important step towards the goal of developing vehicles for precision drug delivery systems that combine therapeutic and diagnostic (theranostic) functionalities with large drug payloads, active targeting, and stimuli‐activated drug release.
The Past, Present, and Future of Adoptive T Cell Therapy (2012)

Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the past few decades, several strategies for enhancing the efficacy of ACT have been developed and introduced in clinic. This review will summarize not only the past approaches but also the latest strategies which have been shown to enhance the anticancer activity of ACT.
Slow Nonradiative Decay for Rare Earths in KPb2Br5 and RbPb2Br5 (2004)

We report on spectroscopic investigations of Nd3+- and Tb3+-doped low phonon energy, moisture-resistant host crystals, KPb2Br5 and RbPb2Br5, and their potential to serve as new solid state laser materials at new wavelengths.
Physiological Basis of Myocardial Contrast Enhancement in Fast Magnetic Resonance Images of 2-Day-Old Reperfused Canine Infarcts (1995)

In contrast-enhanced MR images of 2-day-old reperfused canine infarcts, myocardial regions of hypoenhancement are related to the no-reflow phenomenon. Approximately 90% of the myocardium within hyperenhanced regions is nonviable.
Dual Receptor T‐Cells (1995)

Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.
Dietary mannoheptulose has differential effects on fasting and post-prandial glucose oxidation in Labrador Retrievers (2014)

This study aimed to determine the effects of dietary mannoheptulose (MH; 2 mg kg−1), a glycolytic inhibitor, on glucose oxidation and biomarkers of energy metabolism in neutered, adult, male Labrador Retriever dogs (N = 6). Fasting and post-prandial respiratory quotient (RQ) and energy expenditure (EE) were determined by indirect calorimetry (d 16). Glucose turnover and oxidation were assessed during fasting and repeated meal feeding using indirect calorimetry and a constant intravenous infusion of U-13C-glucose (d 18). A sample from the biceps femoris was obtained to determine the muscle protein content of adenosine monophosphate-activated protein kinase (AMPK) and acetyl CoA carboxylase (ACC; total and phosphorylated forms; d 21). MH did not affect EE, serum glucose, insulin or free fatty acids or ACC protein content. In fasting, MH significantly increased the fasting RQ (p = 0.01) and glucose oxidation (p = 0.01) and tended to decrease the ratio of phosphorylated to total AMPK protein content (p = 0.16). In contrast, post-prandial glucose oxidation tended to be lower (p = 0.14) in dogs fed MH. These results suggest that MH has differential effects on fasting and post-prandial whole body glucose and fat oxidation. However, further research that uses a greater number of animals and/or higher dose of MH is required.
Correlating the extent of pulmonary contusion to vehicle crash parameters in near-side impacts. (2011)

Pulmonary contusion (PC) is the most common injury following blunt thoracic trauma with an associated mortality of 10% to 20%. The purpose of this study is to determine how crash parameters correlate to the volume of pulmonary contusion. The Crash Injury Research Engineering and Network (CIREN) database was queried to extract data on all occupants sustaining PC in a near-side crash. The selected CIREN data included all completed cases from 2005 through 2010. Cases involving a roll-over or without a thorax CT uploaded to the database were excluded. After all cases had been examined the study had 64 occupants with varying volumes of PC. Specific crash characteristics compiled included change in velocity due to the impact, energy, occupant characteristics, side airbag deployment, and crush profile measurements. Crush metrics quantifying the area of the crush profile and the location of the crush relative to the occupant were calculated. The thoracic CT scans from these cases were downloaded and segmented to determine the percent volume of high attenuation lung and PC as compared to the total volume of the lung. The results of the general linear model analysis suggest that maximum crush was the best predictor of high attenuation lung and lung location best predicted PC. An analysis of NASS and CIREN demonstrated that crashes with PC tended to have crash parameters that indicated higher severity. These correlations can be used in the future to develop an injury criterion for PC using finite element metrics.
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids (2021)

Summary Cellular immunotherapies are rapidly gaining clinical importance, yet predictive platforms for modeling their mode of action are lacking. Here, we developed a dynamic immuno-organoid 3D imaging-transcriptomics platform; BEHAV3D, to unravel the behavioral and underlying molecular mechanisms of solid tumor targeting. Applied to an emerging cancer metabolome-sensing immunotherapy: TEGs, we first demonstrate targeting of multiple breast cancer subtypes. Live-tracking of over 120,000 TEGs revealed a diverse behavioral landscape and identified a ‘super engager’ cluster with serial killing capability. Inference of single-cell behavior with transcriptomics identified the gene signature of ‘super engager’ killer TEGs, which contained 27 genes with no previously described T cell function. Furthermore, guided by a dynamic type 1 interferon (IFN-I) signaling module induced by high TEG-sensitive organoids, we show that IFN-I can prime resistant organoids for TEG-mediated killing. Thus, BEHAV3D characterizes behavioral-phenotypic heterogeneity of cellular immunotherapies and holds promise for improving solid tumor-targeting in a patient-specific manner.
New Labdane Diterpenes from the Stem Bark of Larix laricina. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Conformational Analysis of Open‐Chain 1,2:3,4‐Diepoxides: Comparison of crystal structures, NMR data, and molecular‐orbital calculations (1993)

Abstract Several pairs of diastereoisomeric open‐chain 1,2:3,4‐diepoxides with different substitution patterns were prepared (see 3–9 ). As far as possible, crystal structures were determined to corroborate the relative configurations and to give insight into the solid‐state conformations of these compounds. The comparison with our earlier molecular‐orbital calculations and with 1 H‐NMR measurements shows that the solid‐state conformations of eight out of the nine open‐chain 1,2:3,4‐diepoxides, whose crystal structures had been determined, correspond to minima on the calculated energy profiles for these compounds or for closely related derivatives. In solution, highly substituted diepoxides of the erythro ‐series ( e ‐ 6 , e ‐ 7 , e ‐ 9 ) seem to prefer the same conformation as in the crystal. The solution conformations of all other diepoxides differ from the arrangement in the solid state.
Showering Arcs in Breaking Au, Ag, Pd, and W Contacts and Radio Noise Caused by These Arcs (1984)

A showering arc occurs in breaking Au, Ag, Pd, and W contacts under the conditions of the circuit current 0.1-300 mA and source voltage of d.c 10-100 V in case of a non-inductive load. At all of the above contact materials, the characteristics of radio noise caused by the showering arc are similar. The radio noise occurs at the portion corresponding to the dielectric breakdown between the contacts and its noise level depend upon the dielectric breakdown voltage.