gebhart/patrepeval huggingface dataset:
Using environment objects as tools in unknown environments (2015)

Robots should be able to reason about using objects in the environment to assist task completion. If faced with an unexpected situation, such as a critically damaged floor, robots should be able to evaluate different ways to resolve the situation rather than directly declaring failure. In this paper, we present the first online framework that enables robots to reason about using environment objects as tools to overcome obstructions, allowing robots to solve previously unsolvable tasks. The framework utilizes constraint relaxed planning to detect unavoidable obstructions. In case the robot becomes disconnected from the goal by an obstruction, the system guides the robot to search for and utilize an object in the environment to overcome the obstruction using the concept of inverse affordances. We verified the framework in a realistic simulation environment for the PR2 robot.
The chemistry of pentavalent organobismuth reagents. Part 7. The possible role of radical mechanisms in the phenylation process for bismuth(V), and related lead(IV), lodine(III), and antimony(V) reagents (1987)

The phenylation reactions of bismuth(V), lead(IV), and iodine(III) have been examined to test the presence or absence of phenyl radicals. In the case of several bismuth(V) reactions the presence of phenyl radicals has been detected, but it has been shown, by use of a large excess of radical trapping agent, that these radicals have nothing to do with the phenylation process. In the same way, the other phenylation reactions fail to respond to a large excess of a radical trap.
Working in Language and Law: a German Perspective by Hannes Kniffka (2007). Basingstoke: Palgrave Macmillan ISBN 978 02 305 5142 8 (2008)

For those familiar with the field of language and law (characterized broadly as a pairing of linguistic analysis with some aspect of the legal system), Hannes Kniffka, Professor of General and Applied Linguistics at Bonn University, has consistently provided thoughtful and complete analyses of major issues in, especially, Forensic Linguistics (characterized narrowly as the application of linguistic analysis to issues of language evidence). While Kniffka has enjoyed wide readership in Europe, he is less well known in the United States. In the welcome and, arguably long overdue, Working in Language and Law: a German perspective (henceforth WLLGP), Kniffka chronicles his long and active career in the German legal system as a forensic linguist and provides his seasoned perspective on current issues in forensic linguistics.
Generation and characterization of a superior host cell line for biomanufacturing (2015)

Background Chinese hamster ovary (CHO) cells are the most widely used host for large scale production of recombinant therapeutic proteins exhibiting high productivities in the gram per liter range. Although these cells have been extensively characterized and optimized, a demand to further increase the performance towards higher productivity and clonal stability exists. Up to date, the clone selection process is mainly based on phenotypic screens like titer measurements and growth data instead of more reliable biomarkers. Recently, the genomes of Chinese hamster as well as of different CHO cell lines were sequenced, assembled and annotated [1-3]. This new information gives the opportunity for functional analysis of the transcriptome and allows rational designs for the identification of biomarkers for clone selection and targets for cell line engineering.
2.6.2 Evolution of Agile Processes on a Small Program (2003)

Abstract This paper discusses our experience attempting to develop and introduce a web‐based collaborative engineering environment into an organization working in a government contract environment. In a previous paper, we described how we had evolved our processes from ones that control change to processes designed to adapt to a rapidly changing environment. In this paper, we continue the story by discussing how those processes compared to “Extreme Programming” (XP), and how we subsequently benefited from adopting additional elements of XP. To illustrate the points, we use our 2002 task to automate the enterprise Data Management process as an example.
Comparative cytologic yield and quality of three Pap smear instruments. (1993)

To enhance the yield of endocervical cells in Pap smear sampling, consideration should be given to using the cervical brush routinely as a sampling instrument and to taking more than one sample per screening.
Molecular Mechanisms of Anoxia/Reoxygenation-Induced Neutrophil Adherence to Cultured Endothelial Cells (1997)

The objectives of this study were to (1) determine the time course of neutrophil adhesion to monolayers of human umbilical vein endothelial cells (HUVECs) that were exposed to 60 minutes of anoxia followed by 30 to 600 minutes of reoxygenation and (2) define the mechanisms responsible for both the early (minutes) and late (hours) hyperadhesivity of postanoxic HUVECs to human neutrophils. The results clearly demonstrate that anoxia/reoxygenation (A/R) leads to a biphasic increase in neutrophil adhesion to HUVECs, with peak responses occurring at 30 minutes (phase 1) and 240 minutes (phase 2) after reoxygenation. Oxypurinol and catalase inhibited phase-1 adhesion, suggesting a role for xanthine oxidase and H2O2. In comparison, platelet activating factor (PAF) contributed to both phases of neutrophil adhesion. Anti-intercellular adhesion molecule-1 (ICAM-1) and anti-P-selectin antibodies (monoclonal antibodies [mAbs]) attenuated phase-1 neutrophil adhesion, consistent with roles for constitutively expressed ICAM-1 and enhanced surface expression of preformed P-selectin. Phase-2 neutrophil adhesion was attenuated by an anti-E-selectin mAb, indicating a dominant role of this adhesion molecule in the late phase response. Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides containing the nuclear factor-kappa B or activator protein-1 cognate DNA sequences significantly attenuated phase-2 response, suggesting a role for de novo macromolecule synthesis. Surface expression of ICAM-1, P-selectin, and E-selectin on HUVECs correlated with the phase-1 and -2 neutrophil adhesion responses. Collectively, these findings indicate that A/R elicits a two-phase neutrophil-endothelial cell adhesion response that involves transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules.
Supplemental Table 3 from Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence (2023)

&lt;p&gt;Supplemental Table 3 Performance of MDMs in differentiating recurrent CRC from healthy controls in MDM Plasma CRC Surveillance Study. MDM: methylated DNA marker; CRC: colorectal cancer; AUC: area under the receiver operating characteristic curve; CI: confidence interval; NED: no radiographic evidence of disease.&lt;/p&gt;
Topical Delivery of siRNA-Based Spherical Nucleic Acid Nanoparticle Conjugates for Gene Regulation* (2020)

1606Topical application of nucleic acids offers many potential therapeutic advantages for suppressing genes in the skin, and potentially for systemic gene delivery. However, the epidermal barrier typically precludes entry of gene-suppressing therapy unless the barrier is disrupted. We now show that spherical nucleic acid nanoparticle conjugates (SNA-NCs), gold cores surrounded bya dense shell ofhighly oriented, covalently immobilized siRNA, freely penetrate almost 100% of keratinocytes in vitro, mouse skin, and human epidermis within hours after application. Significantly, these structures can be delivered in a commercial moisturizer or phosphate-buffered saline, and do not require barrier disruption or transfection agents, such as liposomes, peptides, or viruses. SNA-NCs targeting epidermal growth factor receptor (EGFR), an important gene for epidermal homeostasis, are &gt;100-fold more potent and suppress longer than siRNA delivered with commercial lipid agents in cultured keratinocytes. Topical delivery of 1.5 µM EGFR siRNA (50 nM SNA-NCs) for 3 wk to hairless mouse skin almost completely abolishes EGFR expression, suppresses downstream ERK phosphorylation, and reduces epidermal thickness by almost 40%. Similarly, EGFR mRNA in human skin equivalents is reduced by 52% after 60 h of treatment with 25 nM EGFR SNA-NCs. Treated skin shows no clinical or histological evidence of toxicity. No cytokine activation in mouse blood or tissue samples is observed, and after 3 wk of topical skin treatment, the SNA structures are virtually undetectable in internal organs. SNA conjugates may be promising agents for personalized, topically delivered gene therapy of cutaneous tumors, skin inflammation, and dominant negative genetic skin disorders.
Les biomarqueurs de l'arthrose (2015)

Coll2-1 a l'inclusion: un marqueur de prdiction d'efficacit du traitementCritre rponse: diminution de la douleur la marche J1 -J90 50% Population totale KL III & IV
Supplementary Figure 3 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes (2023)

Supplementary Figure 3 from A Placenta-Specific Gene Ectopically Activated in Many Human Cancers Is Essentially Involved in Malignant Cell Processes
Computations with the multiple reference frame technique: Flow and temperature fields downstream of an axial fan (2017)

In numerical computations, axial fans are typically abstracted as two-dimensional surfaces, and this forms the basis for the “Lumped Fan” (LF) model. The LF-model relies on experimentally derived P–Q (fan) curves which should conform to the published test codes. Despite its simplicity, the LF-model’s accuracy depends on the application and acceptable error margin. Therefore, with decreasing error margins in thermal engineering, there has been an interest in accurate fan modeling techniques such as “Multiple Reference Frame” (MRF) model. The current effort provides a two-part validation of the MRF model results for an axial fan against the relevant experiments: comparison of the (i) P–Q curves, and (ii) temperature distribution in an electronic enclosure. In the former, both fan models exhibit good agreement with the experiments, however the flow structures determined by the two models exhibit substantial differences. Given these flow structures’ strong influence on the temperature field, the MRF model demonstrates good correlation and significantly better agreement with the measured temperature distribution, compared to those of the LF-model. In light of these findings, benefits, limitations, and possible applications of both models are also discussed.
Mutation of the Planar Cell Polarity Gene VANGL1 in Adolescent Idiopathic Scoliosis (2016)

4.
Experimental and Theoretical Study on the Interchange between Zr and Ti within the MIL‐125‐NH2 Metal Cluster (2021)

This study aims to investigate the effect of replacing Ti with Zr in the SBU of MIL-125-NH<sub>2</sub> . We were able to replace Ti with Zr in the mixed metal synthesis of MIL-125-NH<sub>2</sub> , for the first time. After experimentally confirming the consistency in their framework structure and comparing their morphology, we related the femtosecond light dynamics with photocatalytic CO<sub>2</sub> visible light conversion yield of the different variants in order to establish the composition-function relation in MIL-125 vis a vis CO<sub>2</sub> reduction. Introducing Zr to the system was found to cause structure defects due to missing linkers. The lifetime of the charge carriers for the mixed metal samples were shorter than that of the MIL-125-NH<sub>2</sub> . The study of CO<sub>2</sub> photocatalytic reduction under visible light indicated that the NH<sub>2</sub> group enhances the photocatalytic activity while the Zr incorporation inside the MIL framework introduces no significant improvements. In addition, the material systems were modelled and simulated through DFT calculations which concluded that the decrease of the photocatalytic activity is not related to the system electronic structure, insinuating that defects are the culprit.
Acetyltransferase p300/CBP Associated Factor (PCAF) Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition (2014)

Epigenetic regulation is directed, in part, by the correlated placement of histone post-translational modifications, but the mechanisms controlling correlated modifications are incompletely understood. Correlations arise from crosstalk among modifications and are frequently attributed to protein-protein interactions that recruit enzymes to existing histone modifications. Here we report the use of a peptide array to discover acetyltransferase-mediated crosstalks. We show that p300/CBP associated factor (PCAF)/GCN5 activity depends on the presence of a distal arginine residue of its histone H3 substrate. Modifications to H3 Arg8 decrease PCAF acetylation of H3 Lys14, and kinetic data indicate that arginine citrullination has the strongest effect in decreasing acetylation. Mutagenesis experiments demonstrate that PCAF specifically interprets H3 Arg8 modifications through interaction with residue Tyr640 on the surface of its catalytic domain, and this interaction regulates Lys14 acetylation by substrate discrimination. PCAF discriminates modified peptides as well as semisynthetic proteins and reconstituted nucleosomes bearing Arg8 modifications. Together, this work describes a method for systematically mapping crosstalks and illustrates its application to the discovery and elucidation of novel PCAF crosstalks.
Determination of the absolute stereochemistry of the fungal metabolite (R)-(−)-2-(4′-hydroxyphenyl)-2-hydroxyethanoic acid (pisolithin B) (1991)

The antifungal antibiotic pisolithin B (p-hydroxymandelic acid, 2-(4′-hydroxyphenyl)-2-hydroxyethanoic acid, 1a) was shown to have the absolute (R) configuration. The stereochemistry was established via comparison of its optical rotation to that of its synthetic (R) and (S) enantiomers. The synthetic samples were prepared by the stereospecific reduction of the prochiral α-keto acid, p-hydroxybenzoylformic acid (2-(4′-hydroxyphenyl)-2-oxoethanoic acid, 2a), with (R) or (S)-2,2′-dihydroxy-1,1′-binaphthyl lithium aluminum hydride (BINAL-H). The absolute configuration and enantiomeric purity of both products were determined using the 1 H NMR of their isobutyl esters in the presence of the chiral solvating agent (R)-(−)-2,2,2-trifluoro-1-(9-anthryl)ethanol. Key words: pisolithin B, p-hydroxymandelic acid, antifungal, absolute configuration.
Tempestade de citocinas na COVID-19 (2020)

O termo tempestade de citocinas vem sendo muito utilizado na COVID-19, para definir a resposta inflamatoria exacerbada provocada pela infeccao pelo SARS-CoV-2. Este trabalho tem como objetivo revisar sobre as citocinas inflamatorias envolvidas nesteprocesso, bem como os farmacos corticoides, e anticorpos monoclonais em uso e em pesquisa clinica para o tratamento da COVID-19 incluindo dexametasona e tocilizumabe.
Experimental evidence for gyromagnetic damping in magnetic heads determined by impedance measurements up to 9 GHz (2005)

An electrical circuit model of the impedance of the inductive write element valid to within 10% up to 9 GHz is developed and used to extract the (complex) inductance of the magnetic part of the head as a function of frequency. Comparison with theoretical eddy-current and ferromagnetic resonance models of the permeability indicates that the dominant loss mechanism in these heads is gyromagnetic damping. Impedance measurements on the magnetic recording head are made using a vector network analyzer.
Implicit incorporation of nonlinear elements for unconditionally stable FDTD analysis at coarse time-steps (2002)

A hybrid 3D FDTD algorithm with a fully implicit interface to lumped nonlinear multiport devices is presented. The algorithm is unconditionally stable and converges for arbitrarily strong nonlinearities, high voltages and with any time-step satisfying the Courant condition. In case of a strongly nonlinear bipolar transistor, the new algorithm is by over two orders of magnitude faster than previous FDTD schemes with explicit or semi-implicit interfaces.
Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report (2022)

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.
Zeolites: New Synergistic Agents for Intumescent Fire Retardant Thermoplastic Formulations?Criteria for the Choice of the Zeolite (1996)

The adduct of zeolites in intumescent formulations of thermoplastic polymers (additives: ammonium polyphosphate and pentaerythritol) leads to a great improvement in their fire retardant performance. A classification of different groups (A, X, Y, Mordenite and ZSM-5) is presented. The influence of the physicochemical properties of the zeolites is discussed. TG analyses reveal that the zeolite may act as a catalyst for the development of the intumescent carbonaceous material and stabilize the carbonaceous residue resulting in the degradation of the intumescent shield. Characterized by MAS-NMR 27Al and 29Si, it is proposed that alumino- and silicophosphate species formed are catalysts active for the synthesis of a protective carbon-based material.
Decisions about turns in multiparty conversation (2011)

We present a decision-theoretic approach for guiding turn taking in a spoken dialog system operating in multiparty settings. The proposed methodology couples inferences about multiparty conversational dynamics with assessed costs of different outcomes, to guide turn-taking decisions. Beyond considering uncertainties about outcomes arising from evidential reasoning about the state of a conversation, we endow the system with awareness and methods for handling uncertainties stemming from computational delays in its own perception and production. We illustrate via sample cases how the proposed approach makes decisions, and we investigate the behaviors of the proposed methods via a retrospective analysis on logs collected in a multiparty interaction study.
Isotachophoresis: Theory and Microfluidic Applications (2022)

Isotachophoresis (ITP) is a versatile electrophoretic technique that can be used for sample preconcentration, separation, purification, and mixing, and to control and accelerate chemical reactions. Although the basic technique is nearly a century old and widely used, there is a persistent need for an easily approachable, succinct, and rigorous review of ITP theory and analysis. This is important because the interest and adoption of the technique has grown over the last two decades, especially with its implementation in microfluidics and integration with on-chip chemical and biochemical assays. We here provide a review of ITP theory starting from physicochemical first-principles, including conservation of species, conservation of current, approximation of charge neutrality, pH equilibrium of weak electrolytes, and so-called regulating functions that govern transport dynamics, with a strong emphasis on steady and unsteady transport. We combine these generally applicable (to all types of ITP) theoretical discussions with applications of ITP in the field of microfluidic systems, particularly on-chip biochemical analyses. Our discussion includes principles that govern the ITP focusing of weak and strong electrolytes; ITP dynamics in peak and plateau modes; a review of simulation tools, experimental tools, and detection methods; applications of ITP for on-chip separations and trace analyte manipulation; and design considerations and challenges for microfluidic ITP systems. We conclude with remarks on possible future research directions. The intent of this review is to help make ITP analysis and design principles more accessible to the scientific and engineering communities and to provide a rigorous basis for the increased adoption of ITP in microfluidics.
Demonstrations of diode-pumped and grating-tuned ZnSe:Cr{sup 2+} lasers. Revision 1 (1997)

A diode-side-pumped ZnSe:Cr{sup 2+} laser was operated with a 75 - Watt peak power 1.65 {micro}m InGaAsP/InP pump array. The laser was configured with a ``single-bounce`` architecture to maximize its round-trip gain. Peak output powers of {approx}0.3 Watt were obtained with a 10% - transmitting output coupler and a lightly-doped crystal. The estimated ``mode fill`` of {approx}0.06 will increase with Cr{sup 2+} concentration, raising the output power and extraction efficiency. With a grating tuner and MgF{sub 2}:Co{sup 2+} laser pumping, the laser tuned throughout the 2134 - 2799 nm range.
Doherty Transmitter Based on Monopole Array Antenna Active Load Modulation (2018)

This letter presents a new antenna topology to implement the load modulation in the Doherty transmitter, which resulted in enhancing the bandwidth compared to previous works. The active load modulation is realized by using a monopole array antenna, which serves as both Doherty combiner and wave radiator. The load impedances of amplifiers can be dynamically tuned through the mutual coupling of the array elements. Detailed design equations and procedures are developed. For verification, a Doherty transmitter operating at 1.95-2.10 GHz has been designed and fabricated using GaN HEMT transistors. The prototype transmitter exhibited a power-added efficiency of 53% at peak power level and maintained an efficiency of 43% at 6.8-dB backoff, over the frequency band of 1.95-2.10 GHz.
Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite (2023)

Pathological calcifications may consist of calcium oxalate (CaOx), hydroxyapatite (HAP), and brushite (BRU). The objective of this study was to evaluate the effect of phytate (inositol hexakisphosphate, InsP6), InsP6 hydrolysates, and individual lower InsPs (InsP5, InsP4, InsP3, and InsP2) on the crystallization of CaOx, HAP and BRU in artificial urine. All of the lower InsPs seem to inhibit the crystallization of calcium salts in biological fluids, although our in vitro results showed that InsP6 and InsP5 were stronger inhibitors of CaOx crystallization, and InsP5 and InsP4 were stronger inhibitors of BRU crystallization. For the specific in vitro experimental conditions we examined, the InsPs had very weak effects on HAP crystallization, although it is likely that a different mechanism is responsible for HAP crystallization in vivo. For example, calciprotein particles seem to have an important role in the formation of cardiovascular calcifications in vivo. The experimental conditions that we examined partially reproduced the in vivo conditions of CaOx and BRU crystallization, but not the in vivo conditions of HAP crystallization.
Determination of End-to-End Distances in a Series of TEMPO Diradicals of up to 2.8 nm Length with a New Four-Pulse Double Electron Electron Resonance Experiment (1998)

A four-pulse version of the pulsed double electron electron resonance (DEER) experiment has been applied to a series of TEMPO diradicals with well-defined interradical distances ranging from 1.4 to 2.8 nm (see picture). The new pulse sequence allows broad distributions of electron–electron distances to be measured without dead-time artifacts.