gebhart/patrepeval huggingface dataset:
The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization (2019)

Laminin is a well-defined component of the airway basement membrane (BM). Efficient binding of laminin via multiple interactions is important for nontypeable Haemophilus influenzae (NTHi) colonization in the airway mucosa. In this study, we identified elongation factor thermo-unstable (EF-Tu), l-lactate dehydrogenase (LDH), protein D (PD), and peptidoglycan-associated lipoprotein P6 as novel laminin-binding proteins (Lbps) of NTHi. In parallel with other well-studied Lbps (protein 4 [P4], protein E [PE], protein F [PF], and Haemophilus adhesion and penetration protein [Hap]), EF-Tu, LDH, PD, and P6 exhibited interactions with laminin, and mediated NTHi laminin-dependent adherence to pulmonary epithelial cell lines. More importantly, the NTHi laminin interactome consisting of the well-studied and novel Lbps recognized laminin LG domains from the subunit α chains of laminin-111 and -332, the latter isoform of which is the main laminin in the airway BM. The NTHi interactome mainly targeted multiple heparin-binding domains of laminin. In conclusion, the NTHi interactome exhibited a high plasticity of interactions with different laminin isoforms via multiple heparin-binding sites.
AC impedance analysis of polypyrrole thin films (1987)

The AC impedance spectra of thin polypyrrole films were obtained at open circuit potentials from -0.4 to 0.4 V vs SCE. Two limiting cases are discussed for which simplified equivalent circuits are applicable. At very positive potentials, the predominantly nonfaradaic AC impedance of polypyrrole is very similar to that observed previously for finite porous metallic films. Modeling of the data with the appropriate equivalent circuit permits effective pore diameter and pore number densities of the oxidized film to be estimated. At potentials from -0.4 to -0.3 V, the polypyrrole film is essentially nonelectronically conductive and diffusion of polymer oxidized sites with their associated counterions can be assumed to be linear from the film/substrate electrode interface. The equivalent circuit for the polypyrrole film at these potentials is that previously described for metal oxide, lithium intercalation thin films. Using this model, counterion diffusion coefficients are determined for both semi-infinite and finite diffusion domains. In addition, the limiting low frequency resistance and capacitance of the polypyrrole thin fims was determined and compared to that obtained previously for thicker films of the polymer. The origin of the observed potential dependence of these low frequency circuit components is discussed.
633 Theoretical Analysis on a Dynamic Stability of Gas-Lubricated Bearing with Herring-bone Groove (2003)

In this paper, the mechanism and dynamic stability of gas-lubricated bearing are considered. The pressure distribution which is generated in compressible fluid at the gap of bearing is calculated. The equation of motion is derived using the fluid force acting on a journal which is calculated from the pressure distribution. Based on the derived equation, the numerical simulation of the dynamic behavior of the journal is performed and the stability of the behavior of the journal is investigated. Finally parameter studies are shown.
Real In Vivo Kinematic Differences between Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties (2005)

We did an in vivo fluoroscopic study comparing the sagittal plane kinematics of mobile-bearing and fixed-bearing total knee arthroplasties in a unique group of patients. These patients were part of a larger bilateral randomized controlled outcome trial with each patient having received both types of total knee arthroplasties. Invited patients did three exercises with each of their different knee replacements; extension against gravity, flexion against gravity, and a step-up. These exercises were recorded using video fluoroscopy, and a series of still digital images over the flexion range were retrieved. The relationship of patella tendon angle to knee flexion angle for each patient was derived. The patella tendon angle to knee flexion angle of the mobile-bearing knee behaved in a linear manner more closely replicating the normal knee, whereas the fixed-bearing knee behaved in a nonlinear, more variable manner. This pattern of results was similar for all three exercises with each patient having one knee replacement that behaved differently in the sagittal plane when compared with their other knee replacement. These kinematic differences may explain the clinical differences observed in the randomized controlled trials that compared these two total knee arthroplasties.
50.2: High Reliable In‐Ga‐Zn‐Oxide FET Based Electronic Global Shutter Sensors for In‐Cell Optical Touch Screens and Image Sensors (2011)

Abstract A 6 inch XGA LCD touch screen with optical sensors in its pixels, using oxide semiconductor (OS) FETs has been developed. The extremely low off‐state current of the OS FET facilitates the use of a global shutter and leads to an improved accuracy of touch detection. The possibility of a novel application of a touch screen and an image sensor that is an application of the combination of OS FETs and global shutter is proposed.
Proxy-based Flow Aggregation for Enhanced TCP over GPRS (2003)

Throughout the world, GSM cellular mobile networks are being upgraded to support the &amp;quot;alwayson &amp;quot; General Packet Radio Service (GPRS). Despite the apparent availability of levels of bandwidth not dissimilar to that provided by conventional fixed-wire telephone modems, the user experience using GPRS is considerably worse.
Toward a Stimulus-Response Theory of Environmental Design (2021)

The interaction between man and his physical environment was examined from a stimulus-response point of view. In the interaction the desire for comfort is assumed, such that if the environmental stimulants vary from a point of comfort in one direction, the behavioral response would vary from comfort in the other direction to produce a comfortable balance. This chapter determines the effect that variations in the qualitative characteristics of a space have upon the behavior of its occupants, who are performing a specified task. In all, the most critical of the limitations were the small number of subjects and the treatment of the attributes of space establishing elements as a composite. The treatment data were employed to determine the quantity and quality of interaction, and achievement on a series of programmed educational tasks.
2102 Inhibition of glycolysis modifies distinctive wound and immune pathways across multiple tissue compartments associated with activated autoreactive B Cells (2022)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is the most common form of lupus; however, only one new drug was approved for SLE in the last 60 years. Inhibition of glycolysis via 2- deoxyglucose (2DG), a competitive inhibitor of glucose-6-phosphate, has recently shown efficacy in attenuating tumor growth and reducing autoimmune pathology; however, the mechanism of this efficacy is somewhat unclear. <h3>Methods</h3> To elucidate how 2DG longitudinally modulates pathways within the context of systemic lupus erythematosus (SLE), BXSB.<i>Yaa</i><sup> IL15-/-, CD8-/-</sup> mice, an SLE model, were treated orally with 2DG for 96-hours or 4-weeks, after which the transcriptional profiles of 9 tissues (heart, hippocampus, hypothalamus, kidney, liver, prefrontal cortex, skeletal muscle, small intestine, and spleen) were analyzed using unsupervised clustering and weighted gene correlation network analysis. Principal component analysis showed mice clustered by tissue. <h3>Results</h3> Tissues correlated to activated autoreactive B cells grouped together according to their summary gene expression for modules treatment and two pathway groups, extracellular matrix/fibrin and immune, emerged. However, within each tissue cluster, pathways for each module were uniquely altered by treatment, according to ANOVA. Furthermore, while most pathways identified were grouped into either wound healing or immune, there was little overlap of specific pathways identified between tissues. <h3>Conclusion</h3> These results show that 2DG has a systemic impact altering immune and wound pathways, but in a tissue-specific manner. Ongoing work includes identifying genes that are potentially central to pathway alterations for follow-up analysis. <h3>Lay Summary</h3> 2-deoxyglucose inhibits glycolysis and has been shown to attenuate lupus. It is not well understood how 2DG affects the body systemically, so we assessed the effects of 2DG on nine tissues (heart, hippocampus, hypothalamus, kidney, liver, prefrontal cortex, skeletal muscle, small intestine, and spleen) in lupus prone mice. Each tissue responded to 2DG in a unique manner, indicating that acts on different pathways depending on the tissue being investigated.
Development and Performance Evaluation of Vertical Seismic Isolator with Variable Eigenfrequency (2020)

In recent years, various seismic isolators have been developed to prevent earthquake damage to structural objects. In this study, we developed a vertical seismic isolator that can adjust an eigenfrequency while solving the problems of the previous isolator. We simulated this device using rigid body motion analysis software SimulationX. In addition, we verified this vertical seismic isolator’s performance through shaking tests for typical seismic waves in Japan. The average reduction rate of the acceleration was 28%. Finally, we verified the performance of an eigenfrequency adjustment mechanism through a shaking test and simulation, and a sufficient vibration reduction effect was confirmed.
Gain spectrum measurement using the segmented contact method with an integrated optical amplifier (2014)

The measurement of optical gain utilising a segmented contact and integrated optical amplifier is reported. We show that in a direct comparison of methods, the use of the integrated amplifier allows the gain spectrum to be deduced over wider spectral ranges and to lower carrier densities, as compared to the conventional segmented contact technique.
Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication (2009)

Bis-tetraazamacrocycles such as the bicyclam AMD3100 (1) are a class of potent and selective anti-HIV-1 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the coreceptor for entry of X4 viruses. By sequential replacement and/or deletion of the amino groups within the azamacrocyclic ring systems, we have determined the minimum structural features required for potent antiviral activity in this class of compounds. All eight amino groups are not required for activity, the critical amino groups on a per ring basis are nonidentical, and the overall charge at physiological pH can be reduced without compromising potency. This approach led to the identification of several single ring azamacrocyclic analogues such as AMD3465 (3d), 36, and 40, which exhibit EC(50)'s against the cytopathic effects of HIV-1 of 9.0, 1.0, and 4.0 nM, respectively, antiviral potencies that are comparable to 1 (EC(50) against HIV-1 of 4.0 nM). More importantly, however, the key structural elements of 1 required for antiviral activity may facilitate the design of nonmacrocyclic CXCR4 antagonists suitable for HIV treatment via oral administration.
Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis (2014)

Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus aureus and petrobactin of Bacillus anthracis hold considerable potential as a single or combined treatment for methicillin-resistant S. aureus (MRSA) and anthrax infection, respectively. The biosynthetic pathways for both siderophores involve a nonribosomal peptide synthetase independent siderophore (NIS) synthetase, including SbnE in staphyloferrin B and AsbA in petrobactin. In this study, we developed a biochemical assay specific for NIS synthetases to screen for inhibitors of SbnE and AsbA against a library of marine microbial-derived natural product extracts (NPEs). Analysis of the NPE derived from Streptomyces tempisquensis led to the isolation of the novel antibiotics baulamycins A (BmcA, 6) and B (BmcB, 7). BmcA and BmcB displayed in vitro activity with IC50 values of 4.8 μM and 19 μM against SbnE and 180 μM and 200 μM against AsbA, respectively. Kinetic analysis showed that the compounds function as reversible competitive enzyme inhibitors. Liquid culture studies with S. aureus , B. anthracis , E. coli , and several other bacterial pathogens demonstrated the capacity of these natural products to penetrate bacterial barriers and inhibit growth of both Gram-positive and Gram-negative species. These studies provide proof-of-concept that natural product inhibitors targeting siderophore virulence factors can provide access to novel broad-spectrum antibiotics, which may serve as important leads for the development of potent anti-infective agents.
Effect of Fluoroquinolone Concentration on Selection of Resistant Mutants of Mycobacterium bovis BCG and Staphylococcus aureus (1999)

When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp drop. The plateau region correlated with the presence of first-step resistant mutants. Mutants were not recovered at concentrations above those required for the second sharp drop, thereby defining a mutant prevention concentration (MPC). A C-8-methoxy group lowered the MPC for an N-1-cyclopropyl fluoroquinolone.
Effect of arginine vasopressin on arterial oxygen partial pressure in the chronically catheterized fetal lamb. (1987)

Fetal plasma 2,3-Diphosphoglycerate (2,3-DPG) and glucose levels were observed during infusion of arginine vasopressin into 6 chronically catheterized fetal lambs. Low dose infusion of arginine vasopressin (5-10 mIU/min.) did not change fetal arterial blood gases significantly. At a high concentration of vasopressin (20-40 mIU/min.), infusion for 60 minutes increased fetal arterial pO2 by approximately 5 mmHg (p less than 0.005 by paired t-test), and decreased pCO2 by approximately 2 mmHg (p less than 0.005 by paired t-test) without significant changes in pH. Neither low nor high dose infusion of arginine vasopressin was accompanied by significant changes in 2,3-DPG or the glucose level.
Multiple bonds between transition metals and ‘bare’ main group elements. A reactive manganese–tellurium–manganese framework: synthesis structure, and alkylidene addition (1984)

A bent manganese–tellurium–manganese framework exhibiting multiple bond character has been constructed by treatment of the solvent-stabilized organomanganese complex (η5-C5Me5)Mn(CO)2thf (1; thf = tetrahydrofuran) with aluminium telluride in the presence of aqueous hydrochloric acid; the dinuclear product (µ-Te)[(η5-C5Me5)Mn(CO)2]2(2) isolated in 46% yield has been shown by X-ray crystallography to contain a central ‘bare’ tellurium bridging atom which is attached to two independent (η-C5Me5)Mn(CO)2 moieties via very short Te–Mn bonds [245.9(2)pm]; this compound reacts readily with diazoalkanes to give µ-alkylidene complexes of composition (µ, η2-TeCR2)[(η5C5Me5)Mn(CO)2]2[(3a) R = H, (3b) R = Me].
Model Predictive Control in Industry: Challenges and Opportunities (2015)

With decades of successful application of model predictive control (MPC) to industrial processes, practitioners are now focused on ease of commissioning, monitoring, and automation of maintenance. Many industries do not necessarily need better algorithms, but rather improved usability of existing technologies to allow a limited workforce of varying expertise to easily commission, use, and maintain these valued applications. Continuous performance monitoring, and automated model reidentification are being used as vendors work to deliver automated adaptive MPC. This paper examines industrial practice and emerging research trends towards providing sustained MPC performance.
Discovering the economic impact of rapid 3D seismic assessment (2003)

Limiting risk, reducing capital expenditure, and minimizing time to first commercial production remain priorities in today's oil and gas marketplace. Accordingly, management decisions must be based on sound scientific interpretations as well as valid economic analyses. Retaining quality while reducing time can be a challenge, particularly given the proliferation of project data available to geoscientists and engineers. Innovative methodologies and work processes that streamline the project cycle are in demand.
Fast Wavelength Switching 6 GBd Dual Polarization 16QAM Digital Coherent Burst Mode Receiver (2014)

A commercially available digital supermode distributed Bragg reflector tunable laser is employed as a fast wavelength switching local oscillator (LO) in a dual polarization (DP) 16-quadrature amplitude modulation (16QAM) coherent burst mode receiver. A digital coherence enhancement technique is used to compensate both the Lorentzian and non-Lorentzian distributed phase noise of the tunable LO laser. It is shown that differential decoding is not sufficient to overcome the substantial bit errors caused by the LO laser phase noise. However, the coherence enhancement technique enables the reception of low symbol rate DP-16QAM bursts, with an average optical signal to noise ratio penalty of 3.5 dB observed relative to theory at the forward error correction threshold (1.5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ).
Hierarchical planning about goals and commitments (2013)

We consider the problem of relating an agent's internal state (its beliefs and goals) and its social state (its commitments to and from other agents) as a way to develop a comprehensive account of decision making by agents in a multiagent system. We model this problem in terms of hierarchical task networks (HTNs) and show how HTN planning provides a natural representation and reasoning framework for goals and commitments. Our approach combines a domain-independent theory capturing the lifecycles of goals and commitments, generic patterns of reasoning, and domain models. Specifically, our approach shows how each agent may take into account its capabilities, costs, and preferences as it plans its interactions (captured as operations on commitments) with other agents to attempt to achieve its goals.
Immunotherapy in Systemic Primary (AL) Amyloidosis Using Amyloid-Reactive Monoclonal Antibodies (2003)

Heretofore, treatment of patients with primary or light chain-associated (AL) amyloidosis has been directed toward reducing the synthesis of the amyloidogenic precursor protein through conventional or high-dose cytotoxic antiplasma cell chemotherapy. Although such efforts have extended survival, most often the prognosis remains exceedingly poor due to the persistence (or progression) of the pathologic deposits. The development of murine amyloid-reactive monoclonal antibodies (mAbs) has provided another therapeutic approach; namely, passive immunotherapy. These reagents, prepared against human light chain-related fibrils, recognize an epitope common to the beta-pleated structure of AL and other types of amyloid proteins and can effect rapid amyloidolysis when administered to mice injected with human AL amyloid extracts. One such prototypic antibody, the IgG1kappa mAb 11-1F4, has now been chimerized and is undergoing GMP production for an eventual phase I and II clinical trial in patients with AL amyloidosis. Demonstration of the therapeutic efficacy of this amyloid-reactive mAb would provide an important proof-of-principle that this form of immunotherapy also could benefit individuals with other types of inherited or acquired amyloid-associated disease.
980How stable are localized sources in atrial fibrillation? Shedding light on underlying Mechanisms of persistent atrial fibrillation (2017)

nisms remain to be fully elucidated. We examined the relationship between EAT and atrial myocardium on the histological and biochemical properties. Methods: Human Left atrial appendage (LAA) samples were obtained during routine cardiac surgery (AF group, n=45). The excised LAA specimens were used for histological analysis and measurement of various proteins concentrations. As controls, human LAAs were obtained from autopsy heart (No AF group, n=12) and used for histological analysis. Results: Infiltration of the subepicardial area by adipose tissue was commonly observed in human LAA sections. In sections of human LAA samples, EATpercentage of sections were significantly higher in AF group (no AF: 8.85.6% vs. AF: 15.811.2%, p=0.041). Focusing on EAT area, characteristic fibrotic remodeling of EAT were observed significantly higher in AF group (no AF: 12.910.9% vs. AF: 36.438.9%, p=0.0446). In addition, there were significant positive correlation between EAT-fibrosis and myocardial fibrosis. In AF group, we confirmed that there was a positive correlation between EAT-fibrosis and the number of M1 macrophages in EAT, as determined by immunohistochemical staining against CD11c. Protein concentration analysis in AF group demonstrated that the contents of various inflammatory cytokines (eg, IL-1, IL-6, IL-8, MIP-1, MIP-1, VEGF, MCP-1, and TNF-) and MMPs in EAT were positively correlated with the collagen protein content in atrial myocardium. Interestingly, serum levels of various inflammatory cytokines were not related with the collagen protein content in atrial myocardium. These results indicate that local inflammatory burden between EAT and atrial myocardium could be more effective than systemic inflammation for atrial myocardial fibrosis. Furthermore, we confirmed that the protein content of angiopoietin-like protein 2 (Angptl2) in EAT, not in serum, were positively correlated with the protein content of various inflammatory cytokines, MMPs in EAT and the collagen protein content in atrial myocardium. In addition, the high levels of Angptl2 content in EAT were related with the high levels of Hif-1, phospho-IB, and phospho-p38 MAPK/p38 MAPK content in EAT by western blotting. These data suggest that hypoxia may increase EAT-secreted Angptl2, and which may regulate the protein levels of pro-inflammatory cytokines and pro-fibrotic enzymes. Conclusions: Overall, infiltration of EAT and fibrotic remodeling of EAT are highly associated with myocardial inflammatory fibrosis as a substrate of AF. The qualitative alteration of EAT such as abundance of inflammatory cytokines and fibrotic remodeling which induced by EAT-secreted Angptl2 may be involved in atrial fibrosis.