gebhart/patrepeval huggingface dataset:
Data from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and UVB irradiation to induce necrosis and apoptosis, respectively. Hypochlorous acid (HOCl) oxidation is a new method for inducing primary necrosis and enhancing the immunogenicity of tumor cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We compared the ability of DCs to engulf three different tumor lysate preparations, produce T-helper 1 (T&lt;sub&gt;H&lt;/sub&gt;1)-priming cytokines and chemokines, stimulate mixed leukocyte reactions (MLR), and finally elicit T-cell responses capable of controlling tumor growth &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We showed that DCs engulfed HOCl-oxidized lysate most efficiently stimulated robust MLRs, and elicited strong tumor-specific IFN-γ secretions in autologous T cells. These DCs produced the highest levels of T&lt;sub&gt;H&lt;/sub&gt;1-priming cytokines and chemokines, including interleukin (IL)-12. Mice vaccinated with HOCl-oxidized ID8-ova lysate–pulsed DCs developed T-cell responses that effectively controlled tumor growth. Safety, immunogenicity of autologous DCs pulsed with HOCl-oxidized autologous tumor lysate (OCDC vaccine), clinical efficacy, and progression-free survival (PFS) were evaluated in a pilot study of five subjects with recurrent ovarian cancer. OCDC vaccination produced few grade 1 toxicities and elicited potent T-cell responses against known ovarian tumor antigens. Circulating regulatory T cells and serum IL-10 were also reduced. Two subjects experienced durable PFS of 24 months or more after OCDC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This is the first study showing the potential efficacy of a DC vaccine pulsed with HOCl-oxidized tumor lysate, a novel approach in preparing DC vaccine that is potentially applicable to many cancers. &lt;i&gt;Clin Cancer Res; 19(17); 4801–15. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
It’s time to scale the science in the social sciences (2014)

The social sciences are at a remarkable confluence of events. Advances in computing have made it feasible to analyze data at the scale of the population of the world. How can we combine the depth of inquiry in the social sciences with the scale and robustness of statistics and computer science? Can we decompose complex questions in the social sciences into simpler, more robustly testable hypotheses? We discuss these questions and the role of machine learning in the social sciences.
The Flow Queue CoDel Packet Scheduler and Active Queue Management Algorithm (2018)

This memo presents the FQ-CoDel hybrid packet scheduler and Active
Queue Management (AQM) algorithm, a powerful tool for fighting
bufferbloat and reducing latency. FQ-CoDel mixes packets from
multiple flows and reduces the impact of head-of-line blocking from
bursty traffic. It provides isolation for low-rate traffic such as
DNS, web, and videoconferencing traffic. It improves utilisation
across the networking fabric, especially for bidirectional traffic, by
keeping queue lengths short, and it can be implemented in a memory-
and CPU-efficient fashion across a wide range of hardware.
Delimitation of technologies and impacts in focus in the Smart Energy Transition project (2017)

This paper specifies the scope of the research plan of the Smart Energy Transition project. Since the aims of the project are broad, we need to delimit the scope of our empirical analysis to particular technologies and particular kinds of impacts. The aim of this paper is to make (non-exclusive) delimitations that define the main empirical subject material of the project.
Guided wave tomography in anisotropic media using recursive extrapolation operators (2018)

Guided wave tomography is an advanced technology for quantitative wall thickness mapping to image wall loss due to corrosion or erosion. An inversion approach is used to match the measured phase (time) at a specific frequency to a model. The accuracy of the model determines the sizing accuracy. Particularly for seam welded pipes there is a measurable amount of anisotropy. Moreover, for small defects a ray-tracing based modelling approach is no longer accurate. Both issues are solved by applying a recursive wave field extrapolation operator assuming vertical transverse anisotropy. The inversion scheme is extended by not only estimating the wall loss profile but also the anisotropy, local material changes and transducer ring alignment errors. This makes the approach more robust. The approach will be demonstrated experimentally on different defect sizes, and a comparison will be made between this new approach and an isotropic ray-tracing approach. An example is given in Fig. 1 for a 75 mm wide, 5 mm deep defect. The wave field extrapolation based tomography clearly provides superior results.
Systematic Review of the Management of Ureteroarterial Fistulas After Ileal Conduit Urinary Diversion (2021)

<b>OBJECTIVE.</b> No studies or guidelines exist to direct management of ureteroarterial fistula (UAF) after ileal conduit urinary diversion in which the possible risks and complications associated with stent-graft infection from the conduit flora must be reconciled with those of open surgical repair. This study seeks to characterize the clinical presentation, pathogenesis, and optimal diagnostic and therapeutic management of this entity through a systematic review of the literature. <b>MATERIALS AND METHODS.</b> A systematic search of the English-language literature using the PubMed, Scopus, and ScienceDirect databases was performed: 264 abstracts were identified. From those abstracts, 32 studies comprising 40 patients with 43 UAFs were selected for analysis. Data points including demographics, clinical presentation, UAF specifications, procedural details, postprocedural complications, and clinical outcomes were reviewed. <b>RESULTS.</b> Predisposing factors included female sex, chronic ureteral stent placement, and past surgical intervention and irradiation for pelvic malignancy. Fistulization was overwhelmingly unilateral (95.0% of patients) and included the common iliac artery (90.7% of UAFs). Combined endovascular and endoureteral modalities presented similar outcomes compared with surgical approaches in terms of UAF-related mortality (7.1% vs 13.3%, respectively) and complication rates (28.6% vs 26.7%) during a similar median follow-up period (9.5 vs 14.0 months). Endovascular stent-graft infections were present in 14.3% of cases and represented a leading indication for reintervention after endovascular management (50.0%). <b>CONCLUSION.</b> Short- and intermediate-term outcomes of combined endovascular and endoureteral techniques compare favorably with those of surgical approaches in the treatment of UAF after ileal conduit urinary diversion. Although there is a relatively low stent-graft infection rate, close follow-up within the first year after the procedure is required given the propensity of complications to develop during this window. The use of postprocedural antibiotics is uncertain but is likely prudent.
High Tolerance of Metamaterial Waveguides to Fabrication Variations (2019)

We demonstrate that silicon metamaterial waveguides have a high tolerance to large fabrication variations. We measured only a 5% drop in the Quality factor of a resonator with a metamaterial segment compared to a 40% drop for a wire waveguide segment, with a 50 nm discontinuity.
Unzipping Multiwalled Carbon Nanotubes under Vortex Fluidic Continuous Flow (2022)

Conventional batch processing in terms of unzipping multiwalled carbon nanotubes (MWCNTs) suffers from discontinuity, safety and environmental issues, reproducibility, and limited scalability. We have established a continuous-flow, scalable, and safe process for unzipping MWCNTs, achieving a yield of 75% under flow conditions, without the need for any auxiliary reagents. This involves using a mild oxidant, aqueous hydrogen peroxide, and harnessing the mechanical energy in a vortex fluidic device (VFD) while operating at ambient temperature. The physical properties of the fabricated unzipping MWCNTs were investigated by scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, powder X-ray diffraction, and Raman spectroscopy. This scalable, continuous-flow VFD-enabled fabrication method for unzipping MWCNTs unveils the power of a fluidic vortex confined in a thin film of liquid for nanocarbon structural re-formation and functionalization.
Correction: A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles (2019)

Correction for ‘A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles’ by J. M. Robert Rickel <italic>et al.</italic>, <italic>Lab Chip</italic>, 2018, <bold>18</bold>, 2653–2664.
Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors Based on a Tetrahydro-1(2H)-isoquinolinone Scaffold: Synthesis, Biological Evaluation and X-ray Crystal Structure (2005)

The synthesis, activity and physical properties of two series of novel potent tetrahydro-1(2H)-isoquinolinone based PARP-1 inhibitors are described. The new structural classes with a non-planar ring system interact specifically with the PARP-1 protein at the nicotinamide-binding site.
Extinction ratio degradation in Raman amplified optical communication system (1991)

The extinction ratio of a Raman amplified optical fibre system is investigated. The results show that serious extinction ratio degradation occurs at high pump level. Because the Raman gain increases with pump power, there exists a tradeoff between the extinction ratio and the achievable amplifier gain. A design rule to estimate the suitable pump power is presented.
Exogenous Bone Morphogenetic Protein-7 Fails to Attenuate Renal Fibrosis in Rats with Overload Proteinuria (2004)

In rats with protein-overload proteinuria, renal tubules continue to express BMP-7 but some of the endogenous protein is secreted into the urinary space. Administration of exogenous recombinant BMP-7 had no effect on proteinuria but was associated with a nonsignificant trend towards less interstitial fibrosis at 6 weeks despite significantly higher kidney extracellular matrix gene mRNA levels. These findings suggest that BMP-7 treatment may have anti-fibrotic effects through enhancement of matrix turnover, although overall these effects are modest in proteinuric states in the absence of significant tubular epithelial cell apoptosis and epithelial-mesenchymal transition.
Free-electron-based interferometry for enhanced, phase-resolved near-field imaging (2023)

We propose a novel scheme for phase-resolved near-field imaging using free electrons. Our scheme relies on algorithmic extraction of the complex-valued electron-field coupling. Pre-shaping the electron wavefunction facilitates superior sensitivity relative to the state-of-the-art.
The Analysis of TxID Signal's Effect to Legacy Receivers in ATSC DTV System (2010)

ATSC 방식의 지상파 디지털 TV 방송에서는 단일 주파수 망 구성 시 송신기들과 중계기들이 동일한 주파수를 사용함에 따라 수신기에서 간섭 문제가 발생한다. 이를 해결하기 위하여 ATSC 에서는 각 송신기 및 중계기에 송신기 식별 (TxID: Transmitter Identification) 신호를 할당하여 송신 및 중계 신호에 부가하여 전송하도록 권고하고 있다. 본 논문에서는 기존 DTV 신호에 부가되어 전송되는 TxID 신호가 기존의 상용 수신기에 미치는 영향을 전산실험, 실험실 테스트, 그리고 필드 테스트를 통해 살펴본다. 이러한 테스트 결과에 의하면 TxID 신호가 기존 DTV 신호보다 30 dB 이하의 삽입레벨로 부가하여 전송될 때 상용 DTV 수신기의 TOV(Threshold of Visibility) 의 증가량은 0.17 dB 보다 작았다. 이것은 TxID 신호를 30 dB이하로 부가하여 전송하면 기존의 상용 수신기에 미치는 영향이 거의 없음을 의미한다. When we implement the single frequency network (SFN) in ATSC terrestrial DTV system, there is an interference problem to DTV receivers due to the use of same frequency channel among transmitters and repeaters. To resolve this problem, it is recommended to adopt the transmitter identification signals in transmitting equipments. In this paper, we analyzed the influence suffered by legacy DTV receivers when the TxID signal is added to the DTV transmitting signals and the results were further verified by computer simulation, laboratory test and field test. The above tests show that if the TxID signal is added to the level of -30dB compared to the original DTV signal, the TOV(Threshold Of Visibility) increment in legacy receivers is about 0.17 dB. It means that we can insert and transmit the TxID signal in ATSC terrestrial DTV system without making the negative effect to the legacy DTV receivers.
Analysis and demonstration of policy-based satellite communications resource management (2010)

Bandwidth requirements in the tactical satellite communications (SATCOM) environment are driven by widely varying battle dynamics. Problematically, however, SATCOM resource management is static, with capacity provisioning based on anticipated average peak demand. To overcome the inevitable shortfalls inherent in this approach, two capabilities are required. The first is integrated situational awareness (SA) of SATCOM network status, including views of disruptions and associated impacts. The second required capability is the ability to allocate bandwidth in near real-time to better meet the urgent needs of Warfighters. This paper describes management architectures in which policy-based automation is applied to the dynamic bandwidth allocation problem for tactical satellite networks using policies derived from both current and near-term historical SA data. Resource management, within the broader policy-based network management, needs to track satellite resource pool capacity, current utilization, and allocation based on instantaneous demand. Dynamic allocation of bulk capacity and admission of more granular per data flow level traffic needs to be governed by policies comprising location, time, organization, associated priorities, etc. Simulated communications traffic resulting from realistic operational scenarios is used to analyze dynamic policy-based resource management. Also presented is a design approach and test bed for live demonstrations of policy-based resource management of Internet Protocol (IP) flows over SPACEWAY, a commercial Ka-band multiple-beam packet processing satellite system, interconnected with a terrestrial IP network.
Understanding Nonviral Nucleic Acid Delivery with Quantum Dot-FRET Nanosensors (2012)

Nonviral delivery of nucleic acids is a potentially safe and viable therapeutic modality for inherited and acquired diseases. However, current systems have proven too inefficient for widespread clinical translation. The rational design of improved carriers depends on a quantitative, mechanistic understanding of the rate-limiting barriers to efficient intracellular delivery. Separation of the nucleic acid from the carrier is one of the barriers, which may be analyzed by Förster resonance energy transfer (FRET), a mechanism used to detect interactions between fluorescently labeled molecules. When applied to the molecular components of polymer or lipid-based nanocomplexes, FRET provides information on their complexation status, uptake, release and degradation. Recently, the design of FRET systems incorporating quantum dots as energy donors has led to improved signal stability, allowing prolonged measurements, as well as increased sensitivity, enabling direct detection and the potential for multiplexing. The union of quantum dots and FRET is providing new insights into the mechanisms of nonviral nucleic acid delivery through convergent characterization of delivery barriers, and has the potential to accelerate the design of improved carriers to realize the potential of nucleic acid therapeutics and gene medicine.
Measuring the Effect of Linguistic Resources on Prosody Modeling for Speech Synthesis (2018)

The generation of natural and expressive prosodic contours is an important component of a text-to-speech (TTS) system which, in most classical architectures, relies on the existence of a text-analysis processor that can extract prosody-predictive features and pass them to a statistical learning model. These features can range from basic properties of the input string to rich high-level features which may not be always available when developing a TTS system in a new language with sparse computational resources. In this work we investigate how the prosody model of a speech-synthesis system performs as a function of different predictive feature sets that assume access to a certain amount of rich resources. We investigate, using objective metrics, the effect of relaxing the assumptions on input representations for prosody prediction for 5 languages, and evaluate the perceptual implications for US English.
Out-of-Autoclave Composite Fairing Design, Fabrication, and Test (2011)

This paper documents a recent R&amp;D effort conducted by the Air Force Research Laboratory, Space Vehicles Directorate, to assess the feasibility of fabricating large composite launch vehicle fairings without the use of autoclaves. Two composite manufacturing approaches were demonstrated: vacuum-bag compaction with oven cure and vacuum assisted resin transfer molding with oven cure. For this project, a 2.8-m diameter fairing was developed for the Minotaur IV launch system. The prototype fairing was instrumented and tested up to qualification test loads. No damage or permanent deformations were observed. Measured strain and displacement data were compared to model predictions; trends and amplitudes were generally in agreement.
Large-Area Intercalated 2D-Pb/Graphene Heterostructure as a Platform for Generating Spin-Orbit Torque (2022)

A scalable platform to synthesize ultrathin heavy metals may enable high efficiency charge-to-spin conversion for next-generation spintronics. Here we report the synthesis of air-stable, epitaxially registered monolayer Pb underneath bilayer graphene on SiC (0001) by confinement heteroepitaxy (CHet). Diffraction, spectroscopy, and microscopy reveal CHet-based Pb intercalation predominantly exhibits a mottled hexagonal superstructure due to an ordered network of Frenkel-Kontorova-like domain walls. The system's air stability enables ex-situ spin torque ferromagnetic resonance (ST-FMR) measurements that demonstrate charge-to-spin conversion in graphene/Pb/ferromagnet heterostructures with a 1.5x increase in the effective field ratio compared to control samples.
Fungal Trichothecenes Which Promote Callus Initiation from the Alfalfa Cotyledon (1989)

Journal Article Fungal Trichothecenes Which Promote Callus Initiation from the Alfalfa Cotyledon Get access Akio Kobayashi, Akio Kobayashi Laboratory of Bioresources Chemistry, Department of Agricultural Science, Okayama University, Okayama 700, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshinori Nakae, Yoshinori Nakae Laboratory of Bioresources Chemistry, Department of Agricultural Science, Okayama University, Okayama 700, Japan Search for other works by this author on: Oxford Academic Google Scholar Tetsuya Kawasaki, Tetsuya Kawasaki Laboratory of Bioresources Chemistry, Department of Agricultural Science, Okayama University, Okayama 700, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuyoshi Kawazu Kazuyoshi Kawazu Laboratory of Bioresources Chemistry, Department of Agricultural Science, Okayama University, Okayama 700, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 53, Issue 2, 1 February 1989, Pages 585–590, https://doi.org/10.1080/00021369.1989.10869294 Published: 01 February 1989 Article history Received: 14 October 1988 Published: 01 February 1989
Single and Multiband Acoustic-Wave-Lumped- Element-Resonator (AWLR) Bandpass Filters With Reconfigurable Transfer Function (2016)

New types of single- and multiband acoustic-wave resonator-based bandpass filters (BPFs) with continuously variable transfer function in terms of bandwidth (BW), selectivity, and out-of-band isolation (IS) are presented. They are based on single-/multiband resonant branches that are shaped by high-quality-factor (Q) acoustic-wave-lumped-element resonators (AWLRs) and are connected in parallel to an all-pass network through variable impedance inverters. With the proposed configuration, quasi-elliptic-type passbands with wide fractional BWs (FBWs)-i.e., larger than the electromechanical coupling coefficient k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of its constituent acoustic-wave resonator-can be realized and continuously tuned while preserving the high-Q characteristics of its acoustic-wave resonators. Furthermore, by reconfiguring the location of the transmission zeros (TZs) of the AWLRs, tunable out-of-band IS profiles and asymmetrical passband BWs can be created. The operating principles of the devised spectrally agile filter concept are demonstrated through coupling-matrix-based synthesis and linear-circuit simulations. They are experimentally validated at the UHF band through the realization of: 1) a three-pole/six-TZ single-band prototype at 418 MHz with tunable BW between 0.16 and 0.49 MHz (FBW: 0.5-1.5k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) for an insertion loss (IL) between 3.3 and 1.2 dB (i.e., effective Q > 10000), reconfigurable order (first-to-third-order states), out-of-band IS controllability in terms of BW (18-26.5 MHz at the upper stopband) and magnitude (23-46 dB at 426 MHz), and an intrinsically selectable allpass mode and 2) a six-pole/nine-TZ dual-band BPF with two transmission bands located at 418 and 433.9 MHz. They, respectively, feature symmetrical and asymmetrical BW tuning between 0.3-0.54 and 0.6-1.23 MHz with in-band IL <;1.7 dB for all tunable states.
Testosterone control of nucleic acid content and proliferation of epithelium and stroma in rat seminal vesicles (1976)

Tissue wet weight, nucleic acid content and epithelial and stromal cell numbers were measured in the seminal vesicles of sexually mature male rats. After castration, tissue weight and RNA decreased rapidly and in aprallel to reach, after 14 days, values only 15-20% of those in control (not castrated) animals. During this period, DNA decreased to a much lesser extent (by about 40%), but this change in DNA correlates well with the observed loss of cells from the epithelium. Testosterone in vivo promoted an immediate resynthesis of RNA, the value characteristic of control animals being reached within 80h. Delays occurred in the hormone-induced regain of tissue weight (30h) and DNA (40h), each of which preceded proliferation of the epithelium (40--50h). The cells of the stroma were unaffected by these changes in the androgenic statls of the animal. It is suggested that these proliferative changes in the epithelium cannot account for the previously reported induction by testosterone of basic secretory proteins in this tissue.
Nontargeted analysis of the urine nonpolar sulfateome: a pathway to the nonpolar xenobiotic exposome (2016)

A new way to reveal some of the nonpolar xenobiotic exposome has been developed that applies to urine samples. The value of the method is to suggest xenobiotics for subsequent targeted analysis in the population of people under study, in order to relate the environment to health and disease. Copyright © 2016 John Wiley & Sons, Ltd.