gebhart/patrepeval huggingface dataset:
Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite (2015)

Neural stem cell (NSC) transplantation has the potential to restore function to diseased or damaged nervous tissue, but poor control over cell survival, differentiation, and maturation limits therapeutic prospects. Engineered scaffolds that have the ability to drive neural stem cell behavior can address these limitations facing cell transplantation. Conducting polymers, which have the ability to electrically interface with cells, are attractive scaffolding candidates, but they lack the capacity for simple covalent modification, which would enable surface patterning of biomolecules. In this work, the NSC scaffolding performance of a nanocomposite composed of conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and graphene oxide (GO) nanosheets (GO/PEDOT) is investigated. The GO/PEDOT material is nontoxic and improves NSC differentiation toward the neuronal lineage. Biomolecules interferon-γ (IFNγ) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry. The surfaces support a larger population of neurons when modified with IFNγ and a larger population of oligodendrocytes when modified by PDGF. This work demonstrates the customizability of GO/PEDOT for cell scaffolding applications and underlines its potential for controlling NSC behavior to improve therapeutic potential.
Pseudomonas aeruginosa Infection of Zebrafish Involves both Host and Pathogen Determinants (2009)

Zebrafish (Danio rerio) have a number of strengths as a host model for infection, including genetic tractability, a vertebrate immune system similar to that of mammals, ease and scale of laboratory handling, which allows analysis with reasonable throughput, and transparency, which facilitates visualization of the infection. With these advantages in mind, we examined whether zebrafish could be used to study Pseudomonas aeruginosa pathogenesis and found that infection of zebrafish embryos with live P. aeruginosa (PA14 or PAO1) by microinjection results in embryonic death, unlike infection with Escherichia coli or heat-killed P. aeruginosa, which has no effect. Similar to studies with mice, P. aeruginosa mutants deficient in type three secretion (pscD) or quorum sensing (lasR and mvfR) are attenuated in zebrafish embryos infected at 50 h postfertilization (hpf), a developmental stage when both macrophages and neutrophils are present. In contrast, embryos infected at 28 hpf, when only macrophages are initially present, succumb to lethal challenge with far fewer P. aeruginosa cells than those required for embryos infected at 50 hpf, are susceptible to infection with lasR and pscD deletion mutants, and are moderately resistant to infection with an mvfR mutant. Finally, we show that we can control the outcome of infection through the use of morpholinos, which allow us to shift immune cell numbers, or small molecules (antibiotics), which rescue embryos from lethal challenge. Thus, zebrafish are a novel host model that is well suited for studying the interactions among individual pathogenic functions of P. aeruginosa, the role of individual components of host immune defense, and small-molecule modulators of infection.
Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae (2021)

Cigarette smoke (CS)-induced inflammation leads to a range of diseases including chronic obstructive pulmonary disease and cancer. The gut microbiota is a major modifying environmental factor that determine the severity of cigarette smoke-induced pathology. Microbiomes and metabolites from CS-exposed mice exacerbate lung inflammation via the gut-lung axis of shared mucosal immunity in mice but these systems are expensive to establish and analyse. Zebrafish embryos and larvae have been used to model the effects of cigarette smoking on a range of physiological processes and offer an amenable platform for screening modifiers of cigarette smoke-induced pathologies with key features of low cost and rapid visual readouts. Here we exposed zebrafish larvae to cigarette smoke extract (CSE) and characterised a CSE-induced leukocytic inflammatory phenotype with increased neutrophilic and macrophage inflammation in the gut. The CSE-induced phenotype was exacerbated by co-exposure to microbiota from the faeces of CS-exposed mice, but not control mice. Microbiota could be recovered from the gut of zebrafish and studied in isolation in a screening setting. This demonstrates the utility of the zebrafish-CSE exposure platform for identifying environmental modifiers of cigarette smoking-associated pathology and demonstrates that the CS-exposed mouse gut microbiota potentiates the inflammatory effects of CSE across host species.
Compiling Halide Programs to Push-Memory Accelerators (2021)

Image processing and machine learning applications benefit tremendously from hardware acceleration, but existing compilers target either FPGAs, which sacrifice power and performance for flexible hardware, or ASICs, which rapidly become obsolete as applications change. Programmable domain-specific accelerators have emerged as a promising middle-ground between these two extremes, but such architectures have traditionally been difficult compiler targets. The main obstacle is that these accelerators often use a different memory abstraction than CPUs and GPUs: push memories that send a data stream from one computation kernel to other kernels, possibly reordered. To address the compilation challenges caused by push memories, we propose that the representation of memory in the middle and backend of the compiler be altered to combine storage with address generation and control logic in a single structure -- a unified buffer. We show that this compiler abstraction can be implemented efficiently on a programmable accelerator, and design a memory mapping algorithm that combines polyhedral analysis and software vectorization techniques to target our accelerator. Our evaluation shows that the compiler supports programmability while maintaining high performance. It can compile a wide range of image processing and machine learning applications to our accelerator with 4.7x better runtime and 4.3x better energy-efficiency as compared to an FPGA.
Separation of Glucose and Pentose Sugars by Selective Enzyme Hydrolysis of AFEX-Treated Corn Fiber (2007)

A process was developed to fractionate corn fiber into glucose- and pentose-rich fractions. Corn fiber was ammonia fiber explosion treated at 90°C, using 1 g anhydrous ammonia per gram of dry biomass, 60% moisture, and 30-min residence time. Twenty four hour hydrolysis of ammonia fiber explosion-treated corn fiber with cellulase converted 83% of available glucanto-glucose. In this hydrolysis the hemicellulose was partially broken down with 81% of the xylan and 68% of the arabinan being contained in the hydrolysate after filtration to remove lignin and other insoluble material. Addition of ethanol was used to precipitate and recover the solubilized hemicellulose from the hydrolysate, followed by hydrolysis with 2% (v/v) sulfuric acid to convert the recovered xylan and arabinan to monomeric sugars. Using this method, 57% of xylose and 54% of arabinose available in corn fiber were recovered in a pentose-rich stream. The carbohydrate composition of the pentose-enriched stream was 5% glucose, 57% xylose, 27% arabinose, and 11% galactose. The carbohydrate composition of the glucose-enriched stream was 87% glucose, 5% xylose, 6% arabinose, and 1% galactose, and contained 83% of glucose available from the corn fiber.
Efficient identification of non-Gaussian mixtures (2000)

Non-Gaussian mixtures are commonly used as parametric models for impulsive interference superimposed on a Gaussian background. In this study, the problem of efficient batch and recursive estimation of the parameters of such mixtures via minimization of the Kullback-Leibler distance is considered. The maximum-likelihood estimator (MLE) provides the starting point for the development of these estimators. First, it is shown that the MLE yields consistent estimates of the parameters, despite the existence of multiple roots in the Kullback-Leibler distance function. Since direct implementation of the MLE is difficult, an alternative estimator, designed with the objective of maximizing the likelihood function, is proposed. A simulation study of the proposed estimator reveals that it performs very well in terms of attaining the Cramer-Rao lower bound. Stochastic approximation is also considered in this study. A "complete data" modification to the standard recursion is presented, which greatly facilitates its implementation. Three initiating estimators are developed for these recursions: an iterative likelihood-based scheme, a batch estimator that uses a histogram of the data, and an iterative scheme that integrates the concept of complete data into the method-of-moments estimator. Upon initiating the modified stochastic approximation recursion with these estimators, it is seen that excellent estimates of the parameters can be obtained.
High-Pressure NMR of Polymers Dissolved in Supercritical Carbon Dioxide (1997)

High-pressure, high-resolution proton nuclear magnetic resonance spectroscopy has been utilized to study the solution behavior of poly(1,1-dihydroperfluorooctyl acrylate) (PFOA) and poly(1,1-dihydroperfluorooctyl acrylate-block-styrene) (PFOA-b-PS) in supercritical carbon dioxide. The proton chemical shift was monitored as a function of solvent density and temperature. A change in the solvent quality of CO2 from that of a poor solvent to that of a good solvent is postulated to describe a discontinuous change in the 1H NMR spectra of the polymers with increasing CO2 density and increasing temperature. At a CO2 density of 0.7 g cm-3 at 64.6 °C (0.8 g cm-3 at 41.2 °C) there is an apparent transition between a two-phase systemthe coexistence of two polymer species in different environmentsand a homogeneous solution. The volume fraction of CO2 in the polymer-rich phase is estimated from the proton chemical shift and the contributions from the bulk susceptibilities of PFOA and PFOA-b-PS.
Resource management for extensible Internet servers (1998)

Article Free Access Share on Resource management for extensible Internet servers Authors: Grzegorz Czajkowski Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Chi-Chao Chang Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Chris Hawblitzel Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Deyu Hu Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile , Thorsten von Eicken Department of Computer Science, Cornell University, Ithaca, NY Department of Computer Science, Cornell University, Ithaca, NYView Profile Authors Info & Claims EW 8: Proceedings of the 8th ACM SIGOPS European workshop on Support for composing distributed applicationsSeptember 1998 Pages 33–39https://doi.org/10.1145/319195.319201Online:07 September 1998Publication History 2citation207DownloadsMetricsTotal Citations2Total Downloads207Last 12 Months4Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Electrostatically actuated 1 × 2 micro-mechanicaloptic switch (2001)

A micro-opto-mechanical 1 × 2 switch has been realised using silicon oxynitride (SiON) planar waveguide technology. The operational principle of the switch is based on the mechanical deflection of a cantilever beam due to electrostatic interaction. The device concept and performance is reported. The switch is monolithically integrated on a silicon substrate and has many potential applications in fibre-optic local area networks.
Specific absorption ratio evaluation of penta band antenna for LTE/GSM mobile handset applications (2017)

This paper presents the implementation of Penta band printed antenna for mobile handset applications. The desired frequency bands are achieved by embedding combination of various slots and stubs in the top and bottom layers of the printed circuit board. The antenna operates for the frequency bands of 700 MHz, 850 MHz, 900 MHz, 1575 MHz, 1800 MHz, and 1900 MHz for LTE, GSM, GPS, DCS, and PCS respectively with S11 = - 6 dB matching criteria (VSWR 3:1). The specific absorption ratio of the designed antenna is evaluated for IEEE C95.1-1999 standard with SAR of 0.9 W/kg averaged at 1 g of tissue. The Antenna consists of driven monopole with branch lines. By properly controlling the dimensions of each slot and length of elements, desired frequencies are achieved with good radiation characteristics. The desired operating bands are achieved in a compact area of 15 × 60 mm. The results for the specific absorption ratio plot, 3D gain patterns and s-parameters plot are presented for the proof of concept.
Correction to Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach (2012)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization ApproachTomomi Kosugi, Dale R. Mitchell*, Aiko Fujino, Minoru Imai, Mika Kambe, Shinji Kobayashi, Hiroaki Makino, Yohei Matsueda, Yasuhiro Oue, Kanji Komatsu, Keiichiro Imaizumi, Yuri Sakai, Satoshi Sugiura, Osami Takenouchi, Gen Unoki*, Yuko Yamakoshi, Vicky Cunliffe, Julie Frearson, Richard Gordon, C. John Harris, Heidi Kalloo-Hosein, Joelle Le, Gita Patel, Donald J. Simpson, Brad Sherborne, Peter S. Thomas, Naotaka Suzuki, Midori Takimoto-Kamimura, and Ken-ichiro KataokaCite this: J. Med. Chem. 2012, 55, 22, 10312–10313Publication Date (Web):October 25, 2012Publication History Published online25 October 2012Published inissue 26 November 2012https://doi.org/10.1021/jm3013954Copyright © 2012 American Chemical SocietyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views982Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (174 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
1207: The Therapeutic Effect of Oral Administration of L-Arginine on Bladder Dysfunction in Diabetic Rats (2005)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 24, 2005, 1:00 - 5:00 pm1 Apr 20051207: The Therapeutic Effect of Oral Administration of L-Arginine on Bladder Dysfunction in Diabetic Rats Kazumasa Torimoto, Hiroko Matsuyoshi, Yukio Hayashi, Hitoshi Masuda, Yoshihiro Matsumoto, Kiyohide Fujimoto, Yoshihiko Hirao, William C. de Groat, Michael B. Chancellor, and Naoki Yoshimura Kazumasa TorimotoKazumasa Torimoto More articles by this author , Hiroko MatsuyoshiHiroko Matsuyoshi More articles by this author , Yukio HayashiYukio Hayashi More articles by this author , Hitoshi MasudaHitoshi Masuda More articles by this author , Yoshihiro MatsumotoYoshihiro Matsumoto More articles by this author , Kiyohide FujimotoKiyohide Fujimoto More articles by this author , Yoshihiko HiraoYoshihiko Hirao More articles by this author , William C. de GroatWilliam C. de Groat More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35352-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1207: The Therapeutic Effect of Oral Administration of L-Arginine on Bladder Dysfunction in Diabetic Rats." The Journal of Urology, 173(4S), p. 327 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 327 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Kazumasa Torimoto More articles by this author Hiroko Matsuyoshi More articles by this author Yukio Hayashi More articles by this author Hitoshi Masuda More articles by this author Yoshihiro Matsumoto More articles by this author Kiyohide Fujimoto More articles by this author Yoshihiko Hirao More articles by this author William C. de Groat More articles by this author Michael B. Chancellor More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
ChemInform Abstract: THE STEREOCHEMISTRY OF P‐N BOND CLEAVAGE IN THE STAUDINGEWR‐WITTIG‐TYPE REACTION OF 2‐ANILIDO‐3,4‐DIMETHYL‐5‐PHENYL‐1,3,2‐OXAZAPHOSPHOLIDINE‐2‐THIONES (1978)

Abstract Untersuchungen zeigen, daß die P‐N‐Bindungsspaltung in den diastereomeren Titelverbindungen (2R,4S,5R)‐(II) und (2S,4S,5R)‐(V) in Reaktionen des Staudinger‐Wittig‐Typs unter vollständiger Retention der Konfiguration am P‐Atom des fünfgliedrigen Ringsystems verläuft.
Leading Innovations Towards 5G: Europe'S Perspective In 5G Infrastructure Public-Private Partnership (5G-Ppp) (2017)

The paper elaborates on the technological and architectural innovations researched and developed by 5G-PPP Phase 1 projects and covering innovation areas such as 5G system design and evaluation, novel air interfaces, network management and security as well as virtualization and service deployment aspects.
Physical and Genetic Structure of the Maize Genome Reflects Its Complex Evolutionary History (2007)

Maize (Zea mays L.) is one of the most important cereal crops and a model for the study of genetics, evolution, and domestication. To better understand maize genome organization and to build a framework for genome sequencing, we constructed a sequence-ready fingerprinted contig-based physical map that covers 93.5% of the genome, of which 86.1% is aligned to the genetic map. The fingerprinted contig map contains 25,908 genic markers that enabled us to align nearly 73% of the anchored maize genome to the rice genome. The distribution pattern of expressed sequence tags correlates to that of recombination. In collinear regions, 1 kb in rice corresponds to an average of 3.2 kb in maize, yet maize has a 6-fold genome size expansion. This can be explained by the fact that most rice regions correspond to two regions in maize as a result of its recent polyploid origin. Inversions account for the majority of chromosome structural variations during subsequent maize diploidization. We also find clear evidence of ancient genome duplication predating the divergence of the progenitors of maize and rice. Reconstructing the paleoethnobotany of the maize genome indicates that the progenitors of modern maize contained ten chromosomes.
Activation of Rho Family GTPases by Small Molecules (2018)

Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and differentiation. They are important targets for studies of disease mechanisms as well as drug discovery. Here, we report the characterization of small molecule agonists of one or more of six Rho, Rab, and Ras family GTPases that were first identified through flow cytometry-based, multiplexed high-throughput screening of 200000 compounds. The activators were categorized into three distinct chemical families that are represented by three lead compounds having the highest activity. Virtual screening predicted additional compounds with potential GTPase activating properties. Secondary dose-response assays performed on compounds identified through these screens confirmed agonist activity of 43 compounds. While the lead and second most active small molecules acted as pan activators of multiple GTPase subfamilies, others showed partial selectivity for Ras and Rab proteins. The compounds did not stimulate nucleotide exchange by guanine nucleotide exchange factors and did not protect against GAP-stimulated GTP hydrolysis. The activating properties were caused by a reversible stabilization of the GTP-bound state and prolonged effector protein interactions. Notably, these compounds were active both in vitro and in cell-based assays, and small molecule-mediated changes in Rho GTPase activities were directly coupled to measurable changes in cytoskeletal rearrangements that dictate cell morphology.
Dead‐End Dynamic Filtration of Highly Concentrated CaCO3 Suspensions in the Presence of a Dispersant (2010)

Abstract This work discusses dewatering of CaCO 3 suspensions in the presence of a dispersant (sodium polyacrylate). Suspensions were dewatered using the rotating disk‐aided dead‐end dynamic filtration technique. Dewatering efficiency was studied as a function of the dispersant content and operational parameters (disk rotation speed, filtration pressure). Two dewatering modes, with initial ( i ‐dewatering) and delayed ( d ‐dewatering) dispersant addition, were tested. For concentrated suspensions, the d ‐dewatering allowed higher final dryness and better fluidity than i ‐dewatering with minimum dispersant losses in the filtrate.
Your gaze betrays your age (2017)

Visual attention networks are so pervasive in the human brain that eye movements carry a wealth of information that can be exploited for many purposes. In this paper, we present evidence that information derived from observers' gaze can be used to infer their age. This is the first study showing that simple features extracted from the ordered sequence of fixations and saccades allow us to predict the age of an observer. Eye movements of 101 participants split into 4 age groups (adults, 6–10 year-old, 4–6 year-old and 2 year-old) were recorded while exploring static images. The analysis of observers' gaze provides evidence of age-related differences in viewing patterns. Therefore, we extract from the scanpaths several features, including fixation durations and saccade amplitudes, and learn a direct mapping from those features to age using Gentle AdaBoost classifiers. Experimental results show that the proposed image-blind method succeeds in predicting the age of the observer up to 92% of the time. The use of predicted salience does not further improve the classification's accuracy.