gebhart/patrepeval huggingface dataset:
Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment (2020)

Replication-incompetent adenoviral vectors have been under investigation as a platform to carry a variety of transgenes, and express them as a basis for vaccine development. A replication-incompetent adenoviral vector based on human adenovirus type 26 (Ad26) has been evaluated in several clinical trials. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety and features of recombinant viral vector vaccines. This paper reviews features of the Ad26 vectors, including tabulation of safety and risk assessment characteristics of Ad26-based vaccines. In the Ad26 vector, deletion of E1 gene rendering the vector replication incompetent is combined with additional genetic engineering for vaccine manufacturability and transgene expression optimization. These vaccines can be manufactured in mammalian cell lines at scale providing an effective, flexible system for high-yield manufacturing. Ad26 vector vaccines have favorable thermostability profiles, compatible with vaccine supply chains. Safety data are compiled in the Ad26 vaccine safety database version 4.0, with unblinded data from 23 ongoing and completed clinical studies for 3912 participants in five different Ad26-based vaccine programs. Overall, Ad26-based vaccines have been well tolerated, with no significant safety issues identified. Evaluation of Ad26-based vaccines is continuing, with >114,000 participants vaccinated as of 4th September 2020. Extensive evaluation of immunogenicity in humans shows strong, durable humoral and cellular immune responses. Clinical trials have not revealed impact of pre-existing immunity to Ad26 on vaccine immunogenicity, even in the presence of Ad26 neutralizing antibody titers or Ad26-targeting T cell responses at baseline. The first Ad26-based vaccine, against Ebola virus, received marketing authorization from EC on 1st July 2020, as part of the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen. New developments based on Ad26 vectors are underway, including a COVID-19 vaccine, which is currently in phase 3 of clinical evaluation.
I.V. APD421 (Amisulpride) Prevents Postoperative Nausea and Vomiting (2014)

Kranke, P.*; Eberhart, L.†; Motsch, J.‡; Chassard, D.§; Wallenborn, J.∥; Diemunsch, P.¶; Liu, N.#; Keh, D.**; Bouaziz, H.††; Bergis, M.*; Fox, G.‡‡; Gan, T. J.§§ Author Information
Ten‐Minute Protein Purification and Surface Tethering for Continuous‐Flow Biocatalysis (2017)

Abstract Nature applies enzymatic assembly lines to synthesize bioactive compounds. Inspired by such capabilities, we have developed a facile method for spatially segregating attached enzymes in a continuous‐flow, vortex fluidic device (VFD). Fused His n ‐tags at the protein termini allow rapid bioconjugation and consequent purification through complexation with immobilized metal affinity chromatography (IMAC) resin. Six proteins were purified from complex cell lysates to average homogeneities of 76 %. The most challenging to purify, tobacco epi‐aristolochene synthase, was purified in only ten minutes from cell lysate to near homogeneity (&gt;90 %). Furthermore, this “reaction‐ready” system demonstrated excellent stability during five days of continuous‐flow processing. Towards multi‐step transformations in continuous flow, proteins were arrayed as ordered zones on the reactor surface allowing segregation of catalysts. Ordering enzymes into zones opens up new opportunities for continuous‐flow biosynthesis.
Optimality Properties, Distributed Strategies, and Measurement-Based Evaluation of Coordinated Multicell OFDMA Transmission (2011)

The throughput of multicell systems is inherently limited by interference and the available communication resources. Coordinated resource allocation is the key to efficient performance, but the demand on backhaul signaling and computational resources grows rapidly with number of cells, terminals, and subcarriers. To handle this, we propose a novel multicell framework with dynamic cooperation clusters where each terminal is jointly served by a small set of base stations. Each base station coordinates interference to neighboring terminals only, thus limiting backhaul signalling and making the framework scalable. This framework can describe anything from interference channels to ideal joint multicell transmission. The resource allocation (i.e., precoding and scheduling) is formulated as an optimization problem <formularef refid="deqnP1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(P1)</formularef> with performance described by arbitrary monotonic functions of the signal-to-interference-and-noise ratios (SINRs) and arbitrary linear power constraints. Although <formularef refid="deqnP1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(P1)</formularef> is nonconvex and difficult to solve optimally, we are able to prove: 1) optimality of single-stream beamforming; 2) conditions for full power usage; and 3) a precoding parametrization based on a few parameters between zero and one. These optimality properties are used to propose low-complexity strategies: both a centralized scheme and a distributed version that only requires local channel knowledge and processing. We evaluate the performance on measured multicell channels and observe that the proposed strategies achieve close-to-optimal performance among centralized and distributed solutions, respectively. In addition, we show that multicell interference coordination can give substantial improvements in sum performance, but that joint transmission is very sensitive to synchronization errors and that some terminals can experience performance degradations.
Using a Debye polarization cell to predict double-layer capacitor performance (2001)

Many different circuit models have been proposed for double-layer capacitors (DLCs). Presented in this paper is an evaluation of the Debye polarization cell as a model for a double-layer capacitor (DLC). In comparison to other circuit models, the primary advantage of this model is that the circuit elements can be related to chemical reactions which occur inside the DLC. The circuit element values are found from AC impedance measurements for a DLC and a computer program which utilizes a nonlinear least-squares fitting technique. Variations in circuit element values with DC bias level and manufacturing have been investigated. The performance of the Debye polarization cell in slow discharge and pulse load applications has been compared to actual circuit measurements and to simulated results using a classical equivalent circuit.
VRChain: A Blockchain-Enabled Framework for Visual Homing and Navigation Robots (2022)

Visual homing is a lightweight approach to robot visual navigation. Based upon stored visual information of a home location, the navigation back to this location can be accomplished from any other location in which this location is visible by comparing home to the current image. However, a key challenge of visual homing is that the target home location must be within the robot's field of view (FOV) to start homing. Therefore, this work addresses such a challenge by integrating blockchain technology into the visual homing navigation system. Based on the decentralized feature of blockchain, the proposed solution enables visual homing robots to share their visual homing information and synchronously access the stored data (visual homing information) in the decentralized ledger to establish the navigation path. The navigation path represents a per-robot sequence of views stored in the ledger. If the home location is not in the FOV, the proposed solution permits a robot to find another robot that can see the home location and travel towards that desired location. The evaluation results demonstrate the efficiency of the proposed framework in terms of end-to-end latency, throughput, and scalability.
Caenorhabditis elegans Vulval Induction (2006)

Abstract Study of Caenorhabditis elegans vulval development has improved our understanding of inductive signalling and pattern formation at the single cell level, and has led to the definition of signalling cascades. Studies of signal transduction during vulval development have led to the discovery of what is considered a universal signalling pathway from growth factor receptor to RAS to MAP kinase to the nucleus, and the discovery of the LIN‐12/Notch family of receptors that mediate lateral signalling.
Isolation of a cDNA coding for the glucose-6-phosphatase stabilizing protein (1990)

Conference Article| August 01 1990 Isolation of a cDNA coding for the glucose-6-phosphatase stabilizing protein IAN D. WADDELL; IAN D. WADDELL *Department of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANTON G. ZOMERSCHOE; ANTON G. ZOMERSCHOE †Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANN BURCHELL ANN BURCHELL †Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: November 15 1989 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1990 Biochemical Society1990 Biochem Soc Trans (1990) 18 (4): 582–583. https://doi.org/10.1042/bst0180582 Article history Received: November 15 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation IAN D. WADDELL, ANTON G. ZOMERSCHOE, ANN BURCHELL; Isolation of a cDNA coding for the glucose-6-phosphatase stabilizing protein. Biochem Soc Trans 1 August 1990; 18 (4): 582–583. doi: https://doi.org/10.1042/bst0180582 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: IPTG, isopropylthiogalactoside This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Power, Performance, Area and Thermal Analysis of 2D and 3D ICs at A14 Node Designed with Back-side Power Delivery Network (2022)

In this work, we comprehensively evaluate the impact of using backside power delivery network (BSPDN) for CPU of 2D and 3D designs at A14 node from the aspects of power, performance, area and thermal (PPAT) compared to identical designs of conventional front-side (FS) PDN. 2D BSPDN power consumption is 57% smaller than that of 2D FSPDN at iso-CPU frequency. 3D CPU-on-CPU PDN power consumption shows ~3.8 totally (or ~1.9/CPU) times the 2D FSPDN counterpart. Ring oscillator evaluation shows that logic gates in the IR-drop hotspot region of CPU has worst performance loss <9% and >16% for BSPDN and FSPDN based CPUs respectively while the 3D top CPU can suffer from 25% performance loss. BSPDN based CPU area can be scaled down by 8% compared with the FSPDN counterpart with similar power and performance after physical design and PPA evaluation. Due to the thinning of substrate thickness and the BSPDN process, BSPDN based CPU local temperature can be ~40% more than the FSPDN counterpart, illustrating the importance of considering the heat dissipation for the chips with BSPDN. For the CPU-on-CPU 3D IC with power source/package on the bottom and cooler on the top, the top CPU die has 39% more IR drop than the bottom one while the later has 17% more temperature than the former. This opposite trend may induce additional challenge of power integrity and thermal reliability co-design and optimization for 3D ICs with BSPDN.
Formale Spezifikation von Sicherheitspolitiken für Paketfilter (1900)

ZusammenfassungWird ein Rechnernetz mit dem Internet verbunden, kann jeder Rechner des lokalen Netwerks vom Internet aus erreicht werden. Dadurch kann auch jeder Rechner vom Internet aus angegriffen werden und muß deshalb gegen diese Angriffe geschützt werden. In der Praxis ist dies meist nicht möglich, da der Administrationsaufwand dafür sehr groß ist. Hinzu kommt, daß einige, im lokalen Netz nützliche Dienste wie z. B. NFS über unzureichende Sicherheitsmechanismen verfügen. Deshalb werden für die Kopplung zwischen dem Intranet und dem Internet Firewalls eingesetzt, die nur bestimmte Diensteevtl. angereichert um zusätzliche Sicherheitsmechanismen wie z. B. leistungsfähige Authentifizierungsverfahren — zulassen.Eine wichtige Rolle beim Aufbau von Firewalls spielen Paketfilter. Deren Konfiguration erweist sich als komplex und fehleranfällig. In dieser Arbeit stellen wir ein formales Modell vor, um die von einem Paketfilter durchzusetzende Sicherheitspolitik auf einer abstrakten, benutzerfreundlichen Ebene zu spezifizieren, und zeigen, wie diese automatisch in herkömmliche Filterregeln übersetzt werden kann.
Pitch Tracking using the Generalized Harmonicity Indicator (2008)

For many audio applications, a process is required to obtain an accurate estimate of the fundamental and harmonics of periodic sections of the audio signal. The Generalized Harmonicity Indicator (GHI) is to determine, assess and track the fundamental and harmonic frequencies of consecutive time segments of a speech signal using the Matrix Pencil (MP) technique[i]. Various methods of fundamental and harmonic frequency tracking have been proposed and developed, but most have been based on other low resolution techniques such as FFT and cepstral analyses. This is opposed to using a super-resolution frequency estimation technique as provided by the MP. The prior art in the area of super-resolution speech fundamental determination consists of the "super resolution pitch determinator" (SRPD)[ii] and the "enhanced SRPD" (eSRPD) methods. Because these prior methods do not explicitly process a spectral representation or decomposition of the input audio signal, they are not considered to be in the same class as the MP GHI, although they provide a baseline for comparing different estimation techniques. [i] Haddad, D.M., Sarkar, T.K., Noga, A.J.; "Speech Compression Using the Matrix Pencil Technique"; IEEE 12th DSP Workshop; Sept. 2006; Page(s):218-221. [ii] Y. Medan, E., Yair, D., Chazan, "Super Resolution Pitch Determination of Speech Signals," IEEE Trans. On Signal Processing, ASSP-39(1):40-48, 1991.
Turbulent-boundary-layer noise in the interior of aircraft operating at varying altitudes (1976)

The effect of altitude on the interior noise level of commerical aircraft has been studied. Changes in noise levels are shown to be very closely related to the square of the local air density. Data collected on regularly scheduled flights on the C scale and the A scale are generally seen to be in very good agreement with the predicted changes. Subject Classification: [43]50.50, [43]50.55; [43]28.65.
Structural response of metals to friction-stir welding (2014)

The general trends of grain structure development during friction stir welding (FSW) were studied. The microstructure evolution at relatively low welding temperatures was shown to be primarily governed by grain subdivision. At elevated temperatures, however, discontinuous recrystallization may play a key role. Inhomogeneous microstructure distribution was revealed in stir zone.
Massive MIMO in Line-of-Sight Propagation (2017)

By calculating the effective max-min SINR (signal- to-interference-plus-noise ratio) and the corresponding power controls explicitly, and selectively dropping a small number of mobiles based on a simple and effective algorithm, we demonstrate that for both downlink and uplink, employing maximum-ratio or zero-forcing linear pre-coding and de-coding, Massive MIMO with max- min power control performs comparably in LoS (Line-of-Sight) and iid (independent and identically distributed) Rayleigh fading propagation environments.
A Case Study Regarding Influence of Solvers in Matlab/Simulink for Induction Machine Model in Wind Turbine Simulations (2002)

In the last years Matlab/Simulink® has become the most used software for modelling and simulation of dynamic systems. Wind energy conversion systems are for example such systems because they contain parts with different range for the time constant: wind, turbine, generator, power electronics, transformer and grid. These subsystems are described by differential equations with different simulation steps. The electrical generator and the power converter need the smallest simulation step and therefore, these blocks decide the simulation speed. This paper present important aspects regarding the different implementations of induction machine model, influence of the solvers from Simulink and how the simulation speed can be increase for a wind turbine.
High quality factor-suspended 1D photonic crystal (Phc) extended cavity for bio-sensing (2017)

In this paper we report the consistency in controlling the Q-factor value ranging from 1000 to 80,000 together with good free spectral range (FSR) control between the resonance frequencies of between 30 nm to 62 nm of a long cavity based on SOI. The cavities that were considered in this paper ranged from 2 pm to 6 pm in length. The Q-factors for each resonance obtained for that particular extended cavity were measured in different occasion which has 5% variation in the Q- value over a period of times. We expect that the removal of Silica cladding underneath the silicon waveguide will enhance the Q- value due to better optical confinement within the waveguide.
Identification of HIV gp41 membrane proximal epitope tetramer reactive populations of B220+ B cells and B220lo/neg basophils in gp41 peptide-immunized mice (45.3) (2007)

Abstract 2F5 is a rare, neutralizing human mAb specific for the HIV gp41 membrane proximal region (MPER). Recently, we showed that 2F5 is a cardiolipin-binding, polyreactive autoantibody. To determine if MPER antibodies (Ab) are controlled by tolerance mechanisms, BALB/c mice were immunized with HIV-1 gp140 envelope or gp41 peptides. Immunized mice were screened for serum MPER Ab and for 2F5 antigen-specific B cells using 2F5 epitope B cell tetramers. Immunization in Ribi adjuvant did not induce anti-MPER Ab, whereas similar immunizations in TLR9, an adjuvant designed to break tolerance, did. Interestingly, in mice immunized with gp41 peptide, but not gp140, we found two distinct populations of 2F5 tetramer+ cells in bone marrow, spleen, and blood: a polyclonally-induced B220hi B-cell population that bound 2F5 tetramers via their surface Ig and a B220lo/neg cell population induced by immunization. Histological and cell surface phenotypic analysis of the B220lo/neg 2F5 tetramer+ cells indicated these were primarily basophils that bound 2F5 tetramers via MPER Ab bound to FcR. At present, the immunoregulatory significance of these distinct anti-MPER reactive populations is unknown, but their further characterization and the types of Ab they produce/bind should help in delineating why induction of neutralizing anti-MPER Ab is not achieved, despite the generation of a robust non-neutralizing MPER B cell and Ab response.
Long Term Immune Responses to Pandemic Influenza A/H1N1 Infection in Solid Organ Transplant Recipients (2011)

In solid organ transplant (SOT) recipients it is unknown if natural infection with influenza confers protection from re-infection with the same strain during the next influenza season. The purpose of this study was to determine if infection with pandemic influenza A/H1N1 (pH1N1) resulted in a long-term immunologic response. Transplant recipients with microbiologically proven pH1N1 infection in 2009/2010 underwent humoral and cell-mediated immunity (CMI) testing for pH1N1 just prior to the next influenza season. Concurrent testing for A/Brisbane/59/2007 was done to rule-out cross-reacting antibody. We enrolled 22 adult transplant patients after pH1N1 infection. Follow up testing was done at a median of 7.4 months (range 5.8-15.4) after infection. After excluding those with cross-reactive antibody, 7/19 (36.8%) patients were seroprotected. Detectable pH1N1-specific CD4+ and CD8+ interferon-γ producing T-cells were found in 11/22 (50%) and 8/22 (36.4%) patients respectively. Humoral immunity had a significant correlation with a CD4 response. This is the first study in transplant patients to evaluate long-term humoral and cellular response after natural influenza infection. We show that a substantial proportion of SOT recipients with previous pH1N1 infection lack long-term humoral and cellular immune responses to pH1N1. These patients most likely are at risk for re-infection.
Plastic Part Design (2007)

No AccessInjection Mold Design EngineeringAug 2007Plastic Part DesignDavid O. KazmerDavid O. Kazmerhttps://doi.org/10.3139/9783446434196.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 17-35Print ISBN: 978-3-446-41266-8eISBN: 978-3-446-43419-6 Copyright & Permissions© 2007 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Matrix Metalloproteinases Contribute to Insulin Insufficiency in Zucker Diabetic Fatty Rats (2005)

To assess the molecular changes associated with pancreatic beta-cell dysfunction occurring during the onset of type 2 diabetes, we profiled pancreatic islet mRNAs from diabetic male and high-fat-fed female Zucker diabetic fatty (ZDF) rats and their nondiabetic lean counterparts on custom islet-specific oligonucleotide arrays. The most prominent changes in both the male and female models of type 2 diabetes were increases in the mRNAs encoding proteases and extracellular matrix components that are associated with tissue remodeling and fibrosis. The mRNAs for metalloproteinase (MMP)-2, -12, and -14 were sharply increased with the onset of islet dysfunction and diabetes. Zymography of islet extracts revealed a concurrent, >10-fold increase in MMP-2 protease activity in islets from 9-week-old male ZDF rats. Treatment of female ZDF rats receiving a diabetogenic diet with PD166793, a broad-spectrum MMP inhibitor, substantially prevented diabetes. The effect of this compound was due in part to marked beta-cell expansion. These studies indicate that MMPs contribute to islet fibrosis and insulin insufficiency in ZDF rats. Class-targeted protease inhibitors should be explored for their potential therapeutic utility in preservation of beta-cell mass in type 2 diabetes.
Ultra-wideband signal acquisition by use of channel-interleaved photonic analog-to-digital converter under the assistance of dilated fully convolutional network (2020)

We demonstrate a photonic architecture to enable the separation of ultra-wideband signals. The architecture consists of a channel-interleaved photonic analog-to-digital converter (PADC) and a dilated fully convolutional network (DFCN). The aim of the PADC is to perform ultra-wideband signal acquisition, which introduces the mixing of signals between different frequency bands. To alleviate the interference among wideband signals, the DFCN is applied to reconstruct the waveform of the target signal from the ultra-wideband mixed signals in the time domain. The channel-interleaved PADC provides a wide spectrum reception capability. Relying on the DFCN reconstruction algorithm, the ultra-wideband signals, which are originally mixed up, are effectively separated. Additionally, experimental results show that the DFCN reconstruction algorithm improves the average bit error rate by nearly three orders of magnitude compared with that without the algorithm.
Effets des fumonisines sur la santé du porc : sensibilité aux salmonelles et statut immunitaire (2006)

Effets des fumonisines sur la santé du porc : sensibilité aux salmonelles et statut immunitaire. 38. Journées de la Recherche Porcine