gebhart/patrepeval huggingface dataset:
Spectacle Lenses With Slightly Aspherical Lenslets for Myopia Control: Clinical Trial Design and Baseline Data (2021)

Abstract Objectives: Myopia is a major public health problem and it is essential to find safe and effective means to control its progression. The study design and baseline data are presented for a one-year prospective, double-masked, cross-over, randomized clinical trial evaluating the efficacy of single vision spectacle lenses with concentric rings of slightly aspherical contiguous lenslets technology (SAL) on myopia control. Methods: One hundred 8- to 13-year old Chinese children with a refractive error of -0.75 D to -4.75 D were assigned into two groups. In Group 1, SAL then single vision lenses were each worn for 6 months, and Group 2 wore the lenses in the reversed order. Primary outcomes are axial length and spherical equivalent of cycloplegic refractive error. Secondary outcomes include corneal thickness, anterior chamber depth, lens thickness, visual acuity, and lens adaptation. Results: No significant differences in baseline parameters (cycloplegic spherical equivalent, axial length, age) were found between groups (0.49 &lt; p &lt; 0.94). All children adapted well to the test lenses and there was no significant difference in visual acuity between the SAL and single vision lenses (p = 0.27). Conclusions: The children in the two well balanced groups had comparable visual acuity and adapted well to the test lenses. These results imply the visual acuity can be well improved by SAL lens. Clear visual acuity provide the assurance for good compliance in this longitudinal study.
Synthesis of hybrid dendrimer-star polymers by the RAFT process (2004)

A first generation phosphorus-containing dendrimer with twelve terminal benzyl dithiobenzoate functions was designed and subsequently used as a multifunctional agent to derive hybrid star copolymers consisting of a dendritic core surrounded by twelve polystyrene branches by reversible addition-fragmentation chain transfer (RAFT).
Novel multimode interference devices for wavelength beam splitting/combining (2015)

This paper reviews our recent device design activities on wavelength splitters/combiners. We start with blind optimization of MMIs having rectangular patches, and then based on the physical insight, the device structures are simplified to achieve even better performance. This methodology is applied to low insertion loss for two- and four-wavelength splitters/combiners, and it can be applied to other types of devices.
Reliability and performance limiting defects in low-&#x043A; dielectrics for use as interlayer dielectrics (2010)

Reliability issues of low-κ dielectric thin films are important problems in present day ULSI development. Leakage currents in general as well as reliability issues such as time dependent dielectric breakdown (TDDM) and stress induced leakage currents (SILC) are critical problems that are not yet well understood. A topic of current interest is ultraviolet light curing (UV curing) of low-k materials. An atomic scale understanding of the defects involved in reliability problems of these films is virtually non-existent. We have initiated a study utilizing electron spin resonance (ESR) and electrical measurements which provides some fundamental understanding of the deep level defects likely involved in these reliability problems.
Action of clofazimine on Mycobacterium avium and Mycobacterium intracellulare (1990)

Clofazimine is a member of the phenazine pigment family which has been successfully used in chemotherapy against a variety of mycobacteria including M. avium. The presence of clofazimine in growth medium resulted in higher carotenoid pigmentation in M. avium cells. Carotenoid pigments have been shown to quench superoxide radicals supporting the hypothesis that pigmentation possibly protected cells against superoxide. Clofazimine caused the generation of superoxide radicals in M. intracellulare strain LR163 represented by cyanide-resistant oxygen consumption. The amount of oxygen consumed was dependant upon the clofazimine concentration. This supports the hypothesis that clofazimine is antibiotic via its ability to generate toxic oxygen metabolites. Higher catalase activity was found in extracts of cells grown in the presence of a low concentration of clofazimine. At a higher concentration, the amount of catalase and superoxide dismutase activities were lower than the basal level. This finding did not agree with the hypothesis. At this point the reason for the drop in the activities (i.e. lower than basal level) is not known. Clofazimine was mildly synergistic with rifampicin. This result supports hypothesis that the defense mechanism of M. intracellulare to clofazimine was enzymatic. Clofazimine-resistant derivatives of M. intracellulare strain LR163 have been isolated. Their characterization will provide a direct approach towards determining the mode of action of clofazimine in cells.
Surface localization of Pseudomonas aeruginosa outer membrane porin protein F by using monoclonal antibodies (1983)

Hybridomas secreting highly specific monoclonal antibodies against porin protein F of Pseudomonas aeruginosa were isolated. These antibodies interacted with protein F in outer membranes isolated from strains representing the 17 serotypes of P. aeruginosa and from another 15 clinical isolates from patients with cystic fibrosis. The cell surface localization of antigenic sites on protein F was shown by indirect immunofluorescent techniques with these monoclonal antibodies. No fluorescence was observed on a protein F-deficient strain H283 of P. aeruginosa. Another monoclonal antibody specific for outer membrane lipoprotein H2 of P. aeruginosa showed no fluorescence on intact, wild-type bacterial cells, but was able to interact with a rough, LPS-deficient mutant.
Breaking the Integrin Hinge (1996)

Integrins are heterodimeric (alpha, beta) cell adhesion receptors. We demonstrate that point mutations in the cytoplasmic domains of both the alpha and beta subunits promote constitutive signaling by the integrin alphaIIbbeta3. By generating charge reversal mutations, we show these "activating" mutations may act by disrupting a potential salt bridge between the membrane-proximal portions of the alpha and beta subunit cytoplasmic domains. Thus, the modulation of specific interactions between the alpha and beta subunit cytoplasmic domains may regulate transmembrane signaling through integrins. In addition, these activating mutations induce dominant alterations in cellular behavior, such as the assembly of the extracellular matrix. Consequently, somatic mutations in integrin cytoplasmic domains could have profound effects in vivo on integrin-dependent functions such as matrix assembly, cell migration, and anchorage-dependent cell growth and survival.
Supplementary Methods and Figure Legends from Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K (2023)

&lt;p&gt;PDF file, 112KB.&lt;/p&gt;
A Highly Sensitive Electrochemical Sensor System to Detect and Distinguish Between Glyphosate and Glufosinate (2021)

Glyphosate and Glufosinate are widely used herbicides worldwide for controlling weeds in the agriculture field. The large increase in the herbicides tolerant plants has dramatically affected the level of usage of these herbicides recently. With the growing alarm about the associated toxicity to the environmental and human health, there is a need for direct low concentration detection of these herbicides present at the various food crops products and water. In this work, we present a simple electrochemical sensor to selectively detect glyphosate in presence of Glufosinate a structurally similar phosphorus containing amino acid group. The sensor substrate is made up of an interdigitated Au microelectrode, which was immobilized with glyphosate antibody, bounded with the help of the Dithiobis (succinimidyl propionate) (DSP) crosslinker. The data obtained using non-faradaic EIS method, showed a linear range across the whole dosing interval-10 ng ml −1 to 50 ug ml −1 for glyphosate in presence of the interfering component Glufosinate with the detection limit of 10 ng ml −1 and the sensitivity of 1.323% (change in impedance)/ppb. Further the sensor has been proven to measure the spiked pesticides doses in real oatmeal samples. Such micro-volume, high-sensitive, and selective platform which requires no prior sample preparation can be a potentially game-changing electrochemical on-field sensing device to measure the threshold limit, a precautionary step to alert the common man using the food products and farmers working in the agriculture field.
Magnetic and spectroscopic properties of the .delta..delta.* states of tetrachlorotetrakis(trimethylphosphine)dimolybdenum and .beta.-[tetrachlorobis[1,2-bis(dimethylphosphino)ethane]dimolybdenum]: experimental determination of the energy of a triplet .delta..delta.* state (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic and spectroscopic properties of the .delta..delta.* states of tetrachlorotetrakis(trimethylphosphine)dimolybdenum and .beta.-[tetrachlorobis[1,2-bis(dimethylphosphino)ethane]dimolybdenum]: experimental determination of the energy of a triplet .delta..delta.* stateMichael D. Hopkins, Thomas C. Zietlow, Vincent M. Miskowski, and Harry B. GrayCite this: J. Am. Chem. Soc. 1985, 107, 2, 510–512Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00288a044https://doi.org/10.1021/ja00288a044research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Catalytic Enantioselective Addition of Dialkylzinc to N‐Diphenylphosphinoylimines. A Practical Synthesis of α‐Chiral Amines. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
ACTIVITY OF GMP GRADE ADENOVIRUS GM-CAIX: A NOVEL MOLECULAR TARGETED VACCINE THERAPY FOR KIDNEY CANCER (2009)

You have accessJournal of Urology1 Apr 2009ACTIVITY OF GMP GRADE ADENOVIRUS GM-CAIX: A NOVEL MOLECULAR TARGETED VACCINE THERAPY FOR KIDNEY CANCER Zhenhua Li, Randy Caliliw, Dianzheng Zhang, Yonghui Yang, Jessica Lo, Peter Jun Kim, Fairooz Kabbinavar, Allan J Pantuck, and Arie S Belldegrun Zhenhua LiZhenhua Li More articles by this author , Randy CaliliwRandy Caliliw More articles by this author , Dianzheng ZhangDianzheng Zhang More articles by this author , Yonghui YangYonghui Yang More articles by this author , Jessica LoJessica Lo More articles by this author , Peter Jun KimPeter Jun Kim More articles by this author , Fairooz KabbinavarFairooz Kabbinavar More articles by this author , Allan J PantuckAllan J Pantuck More articles by this author , and Arie S BelldegrunArie S Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60438-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ACTIVITY OF GMP GRADE ADENOVIRUS GM-CAIX: A NOVEL MOLECULAR TARGETED VACCINE THERAPY FOR KIDNEY CANCER." The Journal of Urology, 181(4S), p. 152 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 152 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Zhenhua Li More articles by this author Randy Caliliw More articles by this author Dianzheng Zhang More articles by this author Yonghui Yang More articles by this author Jessica Lo More articles by this author Peter Jun Kim More articles by this author Fairooz Kabbinavar More articles by this author Allan J Pantuck More articles by this author Arie S Belldegrun More articles by this author Expand All Advertisement PDF downloadLoading ...
Cascode Buffer for Monolithic Voltage Conversion Operating at High Input Supply Voltages (2005)

A high-to-low switching DC-DC converter that operates at input supply voltages up to twice the maximum voltage permitted in a nanometer CMOS technology is proposed. The circuit technique is based on a cascode bridge that maintains the steady-state voltage differences among the terminals of all of the transistors within a range imposed by a specific fabrication technology. The proposed circuit technique permits the full integration of active and passive devices of a switching DC-DC converter with a high voltage conversion ratio in a standard low voltage CMOS process. An efficiency of 87.8% is achieved for 3.6 V to 0.9 V conversion, assuming a 0.18 /spl mu/m CMOS technology. The DC-DC converter operates at a switching frequency of 97 MHz while supplying a DC current of 250 mA to the load.
Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an in silico Trial (2021)

In this study, we performed an in silico trial aiming at quantifying the impact of different levels of carb-counting error on glycemic control.
Supplementary Table 1 from Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response (2023)

&lt;p&gt;Cohort characteristics&lt;/p&gt;
Phase and magnitude perceptual sensitivities in nonredundant complex wavelet representations (2004)

The recent development of a nonredundant complex wavelet transform allows a novel framework for image analysis. Work on this representation has recognized that the phase and magnitude of complex coefficients can be related to important geometric properties in images. Existing work on human visual system (HVS) sensitivity offers little guidance in understanding the relative importance of noise (e.g., introduced by lossy coding) in phase components and magnitude components. The distinct geometric significance of the two components would suggest that their respective errors relate to different types of image structure, and thus each would have its own unique HVS sensitivity. In this paper, we extend the study of just-noticeable-differences (JND) to magnitude/phase sensitivities in complex wavelet representations and outline and report on preliminary experiments characterizing them.
Interpolation in the DST and DCT domains (2000)

This paper presents the interpolation properties of the discrete sine and cosine transforms. Interpolation is a two-step process of upsampling to put zeros between data samples followed by filtering to fill in those zeros with interpolated values. Upsampling is accomplished by manipulating transform coefficients and the filtering is done using the convolution-multiplication property of the DSTs and DCTs. When working in the transform domain, the filtering can be done explicitly or implicitly. The explicit filtering requires multiplication by the transform of the filter coefficients but permits control over the frequency characteristics of the filter. The implicit method saves computation because there is no additional multiplication, just the forward transform followed by the longer inverse. New rules for the DSTs and DCTs are presented and explained.
Light Spread Manipulation in Scintillators Using Laser Induced Optical Barriers (2018)

We are using the Laser Induced Optical Barriers (LIOB) technique to fabricate scintillator detectors with combined performance characteristics of the two standard detector types, mechanically pixelated arrays and monolithic crystals. This is done by incorporation of so-called optical barriers that have a refractive index lower than that of the crystal bulk. Such barriers can redirect the scintillation light and allow for control of the light spread in the detector. Previous work has shown that the LIOB technique has the potential to achieve detectors with high transversal and depth of interaction (DOI) resolution simultaneously in a single-side readout configuration, suitable for high resolution PET imaging. However, all designs studied thus far present edge effect issues similarly as in the standard detector categories. In this work we take advantage of the inherent flexibility of the LIOB technique and investigate alternative barrier patterns with the aim to address this problem. Light transport simulations of barrier patterns in LYSO:Ce, with deeper barrier walls moving towards the detector edge show great promise in reducing the edge effect, however there is a trade-off in terms of achievable DOI information. Furthermore, fabrication and characterization of a 20 mm thick LYSO:Ce detector with optical barriers forming a pattern of 1 × 1 × 20mm<sup>3</sup> pixel like structures show that light channeling in laser-processed detectors in agreement with optical barriers with refractive index between 1.2 and 1.4 is achievable.
A new approach for crystallization of copper(ii) oxide hollow nanostructures with superior catalytic and magnetic response (2015)

We report the synthesis of copper(II) oxide hollow nanostructures at ambient pressure and close to room temperature by applying the soft templating effect provided by the confinement of droplets in miniemulsion systems. Particle growth can be explained by considering a mechanism that involves both diffusion and reaction control. The catalytic reduction of p-nitrophenol in aqueous media is used as a model reaction to prove the catalytic activity of the materials: the synthesized hollow structures show nearly 100 times higher rate constants than solid CuO microspheres. The kinetic behavior and the order of the reduction reaction change due to the increase of the surface area of the hollow structures. The synthesis also leads to modification of physical properties such as magnetism.
Nanoscale Architecture of Endoplasmic Reticulum Export Sites and of Golgi Membranes as Determined by Electron Tomography (2008)

Modern architecture is guided by the axiom “form follows function,” which emphasizes the need for the shape of a building or an object to reflect its intended function or purpose. Biologists tend to prefer the phrase “form begets function,” because in living organisms, form not only reflects
Lossless and overhead free DCCP - UDP header conversion (U-DCCP) (2000)

The Datagram Congestion Control Protocol (DCCP) is a transport-layer
protocol that provides upper layers with the ability to use non-
reliable congestion-controlled flows. DCCP is not widely deployed in
the Internet, and the reason for that can be defined as a typical
example of a chicken-egg problem. Even if an application developer
decided to use DCCP, the middle-boxes like firewalls and NATs would
prevent DCCP end-to-end since they lack support for DCCP. Moreover, as
long as the protocol penetration of DCCP does not increase, the
middle-boxes will not handle DCCP properly. To overcome this
challenge, NAT/NATP traversal and UDP encapsulation for DCCP is
already defined. However, the former requires special middle-box
support and the latter introduces overhead. The recent proposal of a
multipath extension for DCCP further underlines the challenge of
efficient middle-box passing as its main goal is to be applied over
the Internet, traversing numerous uncontrolled middle-boxes. This
document introduces a new solution which disguises DCCP during
transmission as UDP without requiring middle-box modification or
introducing any overhead.
Experimental validation of a topology optimized acoustic cavity (2015)

This paper presents the experimental validation of an acoustic cavity designed using topology optimization with the goal of minimizing the sound pressure locally for monochromatic excitation. The presented results show good agreement between simulations and measurements. The effect of damping, errors in the production of the cavity, and variations in operating frequency is discussed and the importance of taking these factors into account in the modeling process is highlighted.
New approaches for coordinate-based meta-analysis of functional neuroimaging studies (2010)

Functional neuroimaging has enabled the detailed, in-vivo delineation of functional and dysfunctional activity in the human brain. The amount of inference, however, that can be drawn from each individual study is limited by inherent drawbacks such as the small sample sizes and low reliability. Additionally, all neuroimaging findings pertain to a specific contrast between experimental conditions, while the actual goal is to elucidate general organisational principles of brain (dys-) function. However, given the ever-increasing number of studies in human brain mapping, an abundance of data is now ready to be synthesized and modelled.
Parallel Synthesis of Poly(amino ether)-Templated Plasmonic Nanoparticles for Transgene Delivery (2014)

Plasmonic nanoparticles have been increasingly investigated for numerous applications in medicine, sensing, and catalysis. In particular, gold nanoparticles have been investigated for separations, sensing, drug/nucleic acid delivery, and bioimaging. In addition, silver nanoparticles demonstrate antibacterial activity, resulting in potential application in treatments against microbial infections, burns, diabetic skin ulcers, and medical devices. Here, we describe the facile, parallel synthesis of both gold and silver nanoparticles using a small set of poly(amino ethers), or PAEs, derived from linear polyamines, under ambient conditions and in absence of additional reagents. The kinetics of nanoparticle formation were dependent on PAE concentration and chemical composition. In addition, yields were significantly greater in case of PAEs when compared to 25 kDa poly(ethylene imine), which was used as a standard catonic polymer. Ultraviolet radiation enhanced the kinetics and the yield of both gold and silver nanoparticles, likely by means of a coreduction effect. PAE-templated gold nanoparticles demonstrated the ability to deliver plasmid DNA, resulting in transgene expression, in 22Rv1 human prostate cancer and MB49 murine bladder cancer cell lines. Taken together, our results indicate that chemically diverse poly(amino ethers) can be employed for rapidly templating the formation of metal nanoparticles under ambient conditions. The simplicity of synthesis and chemical diversity make PAE-templated nanoparticles useful tools for several applications in biotechnology, including nucleic acid delivery.