gebhart/patrepeval huggingface dataset:
Adaptation to Temperature-Induced Delay Variations in Logic Circuits Using Low-Overhead Online Delay Calibration (2007)

Ensuring reliability of operations under increasing temperature and process variations has emerged as a major design concern at nanometer scale. Adaptive systems that can dynamically change its operating conditions (voltage, frequency etc.) to accommodate for temperature and process variation has emerged as a promising solution. Such a system, however, requires efficient design techniques that can detect these variations and calibrate the system dynamically to adapt to the variations. In this paper, we propose a low-overhead design technique that helps an adaptive system to accurately estimate the temperature-induced delay variations and adapt to it, thus avoiding an overly-conservative design approach with respect to temperature variations. The principal idea is to choose the most temperature-sensitive timing paths in a circuit; dynamically transform them to a ring oscillator during calibration; and use the frequency of the ring oscillator to estimate the operating frequency of the system. Simulation results demonstrate the effectiveness of the technique for a set of ISCAS89 benchmark circuits with less than 3% error in delay estimation while incurring 1.7% average overhead in delay, 3.4% in area and 0.2% in power
Epidemiology and outcome research in CKD 5D (2012)

&lt;b&gt;Introduction and Aims:&lt;/b&gt; The Portuguese National Health Service funds haemodialysis (HD) and peritoneal dialysis (PD) treatments using the same bundled payment system, since 2008. However, this package does not include hospitalizations, physician/emergency room visits, access-related procedures and patient transportation. The aim of our study was to evaluate the annual health care expenses of chronic kidney disease (CKD) patients initiating HD with a catheter (CVC) or an arteriovenous fistula (AVF) and PD, in Portugal. &lt;b&gt;Methods:&lt;/b&gt; The study was performed from the Public Administration perspective. One year cost data of 152 CKD patients who consecutively initiated dialysis in our institution in the year 2008 (HD-AVF, n=65; HD-CVC, n=45; PD, n=42) were generated and analyzed, using an intention-to-treat approach. Annual health care expenses were evaluated using a mixed costing method: a) HD and PD treatment expenses were established as the bundled payment of €547.94 per patient-week; b) hospitalizations (inpatient), physician/emergency room visits (outpatient) and transportation data, related or unrelated to kidney failure as defined by the discharge diagnosis [International Classification of Diseases Ninth Revision codes], was captured from the Information Management Division of São João Hospital. Expenditure was determined in accordance with the Ministry of Health and Welfare Ordinance Legislation; c) dialysis access expenses were estimated using a micro-costing approach, using publicly available hospital suppliers' price lists. Multivariate analysis was used to assess the impact of various comorbid factors on the outcome of interest (annual health care expenses). Results are reported in 2010 Euros (€). &lt;b&gt;Results:&lt;/b&gt; Dialysis treatment expenses for HD-AVF, HD-CVC and PD modalities were €28,270, €27,332 and €28,062 per patient-year at risk, respectively (p=0.002). Compared with HD-AVF and PD patients, HD-CVC patients were more likely to have outpatient (€2869 vs. €1794 vs. €1315 per patient-year at risk for, HD-CVC, HD-AVF and PD; p&lt;0.001) and inpatient expenses (€10,554.1 vs. €1324.7 vs. €2052.2 per patient-year at risk, for HD-CVC, HD-AVF and PD; p&lt;0.001). Transportation expenditure were significantly lower in PD modality (€852 vs. €2232 vs. €2099 per patient-year at risk, for PD, HD-AVF and HD-CVC; p&lt;0.001).The costs related to dialysis access for PD, HD-AVF and HD-CVC patients were €1172, €1555 and €4208 per patient-year, respectively (p&lt;0.001). Mean annual health care expenses for HD-AVF, HD-CVC and PD patients were €33,621, €42,855 and €32,282 per patient-year at risk, respectively (p&lt;0.001). In multivariate analysis, PD and HD-AVF modalities were associated with approximately €7500 per patient-year cost savings, compared to HD-CVC modality (β-coefficient= -7364, 95%CI [3749 to 10979]; p&lt;0.001). &lt;b&gt;Conclusions:&lt;/b&gt; Patients who choose PD or HD with a functioning AVF incur significant lower annual health care expenses compared to those who initiate HD with a catheter, in the new Portuguese bundled payment plan.
A SiGe V-band x8 frequency multiplier with high spectral purity (2015)

A compact frequency octupler designed for upper and lower E-band transceivers is implemented in IBM 0.13μm SiGe technology. Three frequency doubler stages are used with harmonic rejection conducted at the first two doublers for wide band spectral purity. With a 0 dBm input power, the frequency octupler reaches above 7.5 dBm output power between 56 GHz to 84 GHz with a peak output power of 13.5 dBm. All even harmonics: 2nd, 4th, 6th, 10th, are suppressed by more than 40 dBc across the frequency band. Moreover, the 6th and 10th harmonics are suppressed by over 40 dBc at temperatures between -40°C to 85°C. The circuit enables an extra input option of a frequency quadrupler and occupies 1.23×1.1 mm2 and consumes 152 mA from a 2.7 V supply.
Oncosuppressive role of p53‐induced miR‐205 in triple negative breast cancer (2012)

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration.
Regulation of Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10 by Fyn Kinase (2004)

Ultraviolet B (UVB) induces phosphorylation of histone H3 at serine 10, and mitogen-activated protein kinases are involved in this signal transduction pathway. Here we provide evidence that Fyn kinase, a member of the Src kinase family, is involved in the UVB-induced phosphorylation of histone H3 at serine 10. UVB distinctly increased Fyn kinase activity and phosphorylation. Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation. UVB-induced phosphorylation of histone H3 at serine 10 was blocked by either a dominant-negative mutant of Fyn (DNM-Fyn) kinase or small interfering RNA of Fyn kinase. UVB-induced phosphorylation and activities of ERKs and protein kinase B/Akt were markedly inhibited by DNM-Fyn kinase. However, DNM-Fyn kinase did not inhibit UVB-induced phosphorylation of p38 MAPK or c-Jun N-terminal kinases. Active Fyn kinase phosphorylated histone H3 at serine 10 in vitro, and the phosphorylated Fyn kinase could translocate into the nucleus of HaCaT cells. These results indicate that Fyn kinase plays a key role in the UVB-induced phosphorylation of histone H3 at serine 10.
Influenza Viruses: An Introduction (2012)

We provide a brief introduction into the genome organization, life cycle, pathogenicity, and host range of influenza A viruses. We also briefly summarize influenza pandemics and currently available measures to control influenza virus outbreaks, including vaccines and antiviral compounds to influenza viruses.
Publisher Correction: Combating subclonal evolution of resistant cancer phenotypes (2018)

The originally published version of this Article contained an error in Figure 4. In panel a, grey boxes surrounding the subclones associated with patients #2 and #4 obscured adjacent portions of the heatmap. This error has now been corrected in both the PDF and HTML versions of the Article.
Depth perception in color-interlaced stereoscopic 3D displays (2013)

Most stereo displays in everyday use employ temporal interlacing—temporally alternating presentation—to deliver different images to the eyes. This yields a temporal disparity between the left and right eyes. The brain interprets this as a spatial disparity thereby yielding a distortion in perceived depth (Mach-Dvorak effect). We asked whether this effect can be minimized by using color interlacing to present images to the eyes. In the first half of a frame, the green channel is presented to the left eye and the red and blue channels to the right eye. In the second half, the channels are reversed: green to right eye, red and blue to left. With a desaturated stimulus, both eyes are stimulated in both half frames, so luminance variation is greatly reduced. If the visual system computes disparity from luminance, color interlacing should significantly reduce depth distortions. If it computes disparity in part from chromatic information, two objects at different depths should be perceived, one caused by temporal disparity in green and the other caused by the opposite disparity in red and blue. We performed psychophysical experiments to determine how color interlacing affects the Mach-Dvorak effect. The stimulus consisted of disks rotating on a circular path. The plane of rotation was nominally frontoparallel, but when depth distortion occurred, it appeared slanted. We added a disparity gradient to eliminate the perceived slant and that gradient quantified the distortion. We presented different colors, varying in hue and saturation. When the exchanges were isoluminant, no depth distortion was observed. When they were non-isoluminant, distortion was observed and its magnitude was proportional to the luminance change. The results show that disparity is measured from luminance variation and that display protocols that minimize the luminance variation at each eye yield reduced distortions in perceived depth. Meeting abstract presented at VSS 2013
The Cotton Effect Associated with Certain Tyrosine Residues in Ribonuclease1 (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Cotton Effect Associated with Certain Tyrosine Residues in Ribonuclease1Alexander N. Glazer and Norman S. SimmonsCite this: J. Am. Chem. Soc. 1965, 87, 17, 3991–3993Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/ja01095a043https://doi.org/10.1021/ja01095a043research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunocytochemical Localization of the Neuropeptide-Synthesizing Enzyme PC1 in AtT-20 Cells (1993)

The subtilisin-like enzyme PC1 (also known as PC3) cleaves the neuropeptide precursor proopiomelanocortin at paired basic residues in transfection experiments, thus providing evidence for a critical role in precursor processing. While mRNA for this enzyme is highly enriched in neuroendocrine tissues, little is known about the tissue and subcellular distribution of the PC1 protein. This study used immunocytochemical techniques to investigate the anatomical distribution of PC1, both alone and compared to met-enkephalin (MET-enk), in AtT-20 pituicytes transfected with proenkephalin cDNA. A high density of PC1 immunostaining was observed in a small region adjacent to the nucleus and in the tips of the processes of these cells. Dual-staining immunocytochemistry of whole cells illustrated that both PC1 and MET-enk immunoreactivity were present in the tips, but PC1 was concentrated in a region adjacent to the nucleus while MET-enk punctate staining was dispersed throughout the soma. This codistribution was confirmed in semithin sections of dual-stained cells cut at 1-1.5 microns through the thickness of the cells. PC1 staining resembled that of TGN38, a marker for the trans-Golgi network. When PC1 immunocytochemistry was performed in cells that were pretreated with brefeldin A, a drug that redistributes the proximal Golgi compartments to the endoplasmic reticulum, there was a complete disruption of the defined locus of PC1 immunoreactivity. Taken together, our data indicate that (1) PC1 is concentrated in a region of the cell body resembling the trans-Golgi network and (2) both the enzyme and the processed peptide are transported to the tips of the processes.(ABSTRACT TRUNCATED AT 250 WORDS)
Supplementary Table 3 from Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress (2023)

&lt;p&gt;Excel spreadsheet of NUAK1 inhibitor induced phospho-peptide alterations&lt;/p&gt;
COVID-19 wastewater surveillance implemented in the Tokyo 2020 Olympic and Paralympic Village (2022)

Wastewater-based epidemiology was implemented in the Olympic and Paralympic Village to better understand COVID-19 incidence. SARS-CoV-2 RNA was detected in a number of wastewater samples even when no positive individual was identified in the corresponding areas. Wastewater-based epidemiology can be a useful tool to control infections at mass gatherings.
All‐optical monitoring of excitation–secretion coupling demonstrates that SV2A functions downstream of evoked Ca2+ entry (2021)

SV2A, an essential transporter-like synaptic vesicle protein, is a major target for antiepileptic drugs and a receptor for clostridial neurotoxins including Botox. While SV2A is required for normal levels of evoked neurotransmitter release, the mechanism underlying this role remains unclear. Here, we introduce a new chemogenetic approach for all-optical monitoring of excitation-secretion coupling, and we demonstrate its use in characterizing the SV2A knockout (KO) phenotype in cultured hippocampal neurons. This method employs the HaloTag system to target a robust small-molecule Ca<sup>2+</sup> indicator, JF<sub>646</sub> -BAPTA, to the presynaptic compartment. The far-red fluorescence of this indicator enables multiplexing with the fluorescent glutamate sensor iGluSnFR for detection of presynaptic Ca<sup>2+</sup> influx and glutamate release at the same axonal boutons. Evoked glutamate release probability was reduced in SV2A KO neurons without a change in presynaptic Ca<sup>2+</sup> entry, suggesting that SV2A supports vesicle fusion by increasing the functional availability, or efficiency, of the Ca<sup>2+</sup> -regulated membrane fusion machinery. KEY POINTS: One of the most prescribed antiepileptic medications, levetiracetam, acts by binding a protein of uncertain molecular function. This transporter-like protein, SV2A, is trafficked to synaptic vesicles and acts to support neurotransmitter release, but the mechanism underlying this function has not been determined In this study, we sought to establish whether SV2A changes Ca<sup>2+</sup> signalling at nerve terminals, which is a key regulatory system for synaptic vesicle exocytosis. To do so, we adapted new chemogenetic tools to perform all-optical measurements of presynaptic Ca<sup>2+</sup> and glutamate release in neurons lacking SV2A. Our measurements showed that loss of SV2A reduces glutamate release without reducing Ca<sup>2+</sup> influx at hippocampal nerve terminals, demonstrating that SV2A increases the likelihood that Ca<sup>2+</sup> will trigger synaptic vesicle fusion.
Bayesian inference of visual motion boundaries (2003)

This chapter adch-esses an open problem in visual motion analysis, the estimation of image motion in the vicinity of occlusion boundaries. With a Bayesian formulation, local image motion is explained in terms of multiple, competing, nonlinear models, including models for smooth (translational) motion and for motion boundaries. The generarive model for motion boundaries explicitly encodes the orientation of the boundary, the velocities on either side, the motion of the occluding edge over time, and the appearance/disappearance of pixels at the boundary. We formulate the posterior probability distribution over the models and model parameters, conditioned on the image sequence. Approximate inference is achieved with a combination of tools: A Bayesian filter provides for online computation; factored sampling allows us to represent multimodal nonGaussian distributions and to propagate beliefs with nonlinear dynamics from one time to the next; and mixture models are used to simplify the computation of joint prediction distributions in the Bayesian filter. To efficiently represent such a high-dimensional space we also initialize samples using the responses of a lowlevel motion discontinuity detector. The basic formulation and computational model provide a general probabilistic framework for motion estimation with multiple, non-linear, models.
COVID-19 meets neurointervention on the pages of JNIS (2021)

As 2019 came to a close, a novel B-coronavirus, labeled by the World Health Organization as COVID-19, was noted to be spreading in China.1 The COVID-19 virus is an enveloped single-strand, positive-sense RNA, which means that the virus can use its RNA as the template from which to create proteins needed for propagation and, ultimately, spread. The name coronavirus refers to the characteristic crown-like appearance of these viruses that is seen on electron microscopy. By spring 2020, COVID-19 was spreading rapidly throughout the United States and Europe, and neurointerventionalists soon found themselves on the frontline.2 The Journal of NeuroInterventional Surgery (JNIS) rapidly became the home for emerging research aimed at promoting the safe management of patients with COVID-19 and concomitant cerebrovascular disease and in understanding the consequences of the pandemic on patients, providers, and stroke care.

COVID-19 was initially described largely in terms of its protean pulmonary manifestations, but it soon became apparent that thrombogenic tendencies elevated the risk of stroke.3 Understanding how to approach potentially infectious patients became a major focus of a diverse group of articles being submitted to JNIS .4 New York City …
Pernicious anemia caused by Crohn's disease of the stomach. (1979)

A patient with granulomatous gastritis is described. Two years after the presentation of his gastric disease he developed pernicious anemia. Lack of intrinsic factor production secondary to Crohn's disease of the stomach is felt to be the cause of his Vitamin B12 malabsorption.
Visible Light Induced Reversible Extrusion of Nitric Oxide from a Ruthenium(II) Nitrosyl Complex:  A Facile Delivery of Nitric Oxide (2005)

The new ruthenium compound [Ru(NO)(pysiS4)]Br (3) (pysiS4 = 2,6-bis(3-triphenylsilyl-2-sulfanylphenylthiomethyl)pyridine), containing sterically bulky SiPh3 groups ortho to the thiolate donors, has been synthesized. In solution, 3 releases NO efficiently on exposure to visible light (λ ≥ 455 nm) at room temperature to afford [Ru(Br)(pysiS4)] (4). Treatment of 4 with NO yielded exclusively 3 without any metal-bound side reaction.
Fine Motor Skills of Children With Amblyopia Improve Following Binocular Treatment (2016)

Binocular treatment provided by dichoptic iPod game play improved FMS performance in children with amblyopia, particularly in those with less severe amblyopia. Improvements were maintained at 3 months following cessation of treatment.
Synthesis and characterization of carboxyl endfunctionalized poly(methylidene malonate 2.1.2) (2007)

Abstract α-Carboxyl end-functionalized poly(methylidene malonates 2.1.2) were prepared by free-radical polymerization in the molecular weight range 5 000 - 10 000 by using 4,4'-azobis(4-cyanopentanoic acid) as a functional initiator. A functionality of one carboxyl group per chain could be obtained. On the contrary, it was demonstrated that chain transfer functionalization with mercaptans is not applicable in this case. A Michael addition reaction between the mercaptan and the monomer becomes the predominant side-reaction. The corresponding mercaptanmonomer adduct was characterized in detail by 1 H and 13 C NMR.
FT-FIR-spektroskopische Untersuchung von Liganden-freien Metall-Clustern; Einfluß der Matrix auf die Struktur von Cr3-Molekülen (2006)

Das vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 92. DOI: 10.1002/ange.198300920
An 800MHz embedded DRAM with a concurrent refresh mode (2004)

The embedded DRAM employs a transfer gate formed from a 22A Gox, 1.5V logic IO device resulting in 3.2ns cycle and latency. A concurrent refresh mode and a refresh scheduler prove /spl ges/:99% memory availability for a 64/spl mu/s cell retention time. In-macro circuitry supports redundancy allocation during 800MHz multi-banking operation.
Design and In Vitro Testing of Pressure-Sensing Syringe for Endotracheal Tube Cuffs (2013)

*Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge; and †Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Supp Figure 3 from Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression (2023)

&lt;p&gt;Combination therapy of G1T28 and topotecan does not cause a DDI effect.&lt;/p&gt;
Monolayers of Poly(ethylene oxide)-Bearing Lipids at Air-Water Interface (1996)

Abstract Monolayers of poly(ethylene oxide)-bearing lipids and their mixed monolayers with dimyristoylphosphatidylcholine at the air-water interface was investigated using surface pressure measurements. The surface pressure-area relationship revealed that the poly(ethylene oxide) moiety length significantly affected the interaction among the lipid molecules. This study provided a precise picture of the lipid membrane-water interface.
A Geometric Approach to Information-Theoretic Private Information Retrieval (2005)

A t-private private information retrieval (PIR) scheme allows a user to retrieve the ith bit of an n-bit string x replicated among k servers, while any coalition of up to t servers learns no information about i. We present a new geometric approach to PIR, and obtain: 1) a t-private k-server protocol with communication O((k/sup 2//t) log k n/sup 1//spl lfloor//(2k - 1)/spl rfloor/) removing the (t) term of previous schemes. This answers an open question of Ishai and Kushilevitz (1999). 2) A 2-server protocol with O(n/sup 1/3/) communication, polynomial preprocessing, and online work O(n/log/sup r/ n) for any constant r. This improves the O(n/log/sup 2/ n) work of Beimel et al. (2000). 3) Smaller communication for instance hiding, PIR with a polylogarithmic number of servers, robust PIR, and PIR with fixed answer sizes. To illustrate the power of our approach, we also give alternative, geometric proofs of some of the best 1-private upper bounds.