gebhart/patrepeval huggingface dataset:
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow (2006)

Targeted ultrasound contrast materials (gas-filled microbubbles carrying ligands to endothelial selectins or integrins) have been investigated as potential molecular imaging agents. Such microbubbles normally exhibit good targeting capability at the slower flow conditions. However, in the conditions of vigorous flow, binding may be limited. Here, we describe a microbubble capable of efficient binding to targets both in slow and fast flow (exceeding 4 dyne/cm(2) wall shear stress) using a clustered polymeric form of the fast-binding selectin ligand sialyl Lewis(X). Microbubbles were prepared from decafluorobutane gas and stabilized with a monolayer of phosphatidylcholine, PEG stearate and biotin-PEG-lipid. Biotinylated PSLe(x) (sialyl Lewis(X) polyacrylamide) or biotinylated anti-P-selectin antibody (RB40.34) was attached to microbubbles via a streptavidin bridge. In a parallel plate flow chamber targeted adhesion model, PSLe(x) bubbles demonstrated specific adhesion, retention and slow rolling on P-selectin-coated plates. Efficiency of firm targeted adhesion to a P-selectin surface (140 molecules/microm(2)) was comparable for antibody-carrying bubbles and PSLe(x)-targeted bubbles at 0.68 dyne/cm(2) shear stress. At fast flow (4.45 dyne/cm(2)), PSLe(x)-targeted bubbles maintained their ability to bind, while antibody-mediated targeting dropped more than 20-fold. At lower surface density of P-selectin (7 molecules/microm(2)), targeting via PSLe(x) was more efficient than via antibody under all the flow conditions tested. Negative control casein-coated plates did not retain bubbles in the range of flow conditions studied. To confirm echogenicity, targeted PSLe(x)-bubbles were visualized on P-selectin-coated polystyrene plates by ultrasound imaging with a clinical scanner operated in pulse inversion mode; control plates lacking targeted bubbles did not show significant acoustic backscatter. In vivo, in a murine model of inflammation in the femoral vein setting, targeting efficacy of intravenously administered PSLe(x)-microbubbles was comparable with targeting mediated by anti-P-selectin antibody, and significantly exceeded the accumulation of non-targeted control bubbles. In the inflamed femoral artery setting, PSLe(x)-mediated microbubble targeting was superior to antibody-mediated targeting.
High coercivity Co-alloy thin films on polymer substrates (2001)

Films of (101~0) textured CoCrPt have been sputtered on polymer substrates for use as thin film tape media. Underlayers of NiAl combined with various intermediate layers were employed to obtain this orientation without thermal damage to the polymer. It was found that NiAl underlayers sputtered on tape substrates have a [112] growth texture, like they do on glass. Film coercivity varied as a function of intermediate layers used, with the highest value of coercivity (3800 Oe) being obtained with a composite intermediate layer of CrMn/CoCrMn. TEM observation showed that the CoCrMn component of these intermediate layers was hexagonal with a (101~0) texture and low stacking fault density. The CoCrPt layers deposited on these CoCrMn layers had uniform grains with a lower stacking fault density, possibly due to grain-to-grain epitaxial growth of CoCrPt on CoCrMn.
Physical Properties of Shinayaka Hair and Fine Technology to Control Internal Hair Properties (2017)

髪の理想的な状態については, つや・まとまり・触感などさまざまな視点での研究がある。ここでは, 日本人女性の理想の髪の一つである「しなやかさ」という動きを伴う美しさに着目した。しなやかな髪は, たとえば毛束が流体のように連続的に変形する柔らかさと, 乱れても元の形状に戻る弾力性を兼ね備えている。われわれはまず, しなやかな髪の内部構造と物性について検討した。先天的にしなやかな髪としなやかでない髪の内部構造を比較した結果, 先天的にしなやかな髪は, 弾性率の異なる二種類のコルテックス細胞の構造の分布に偏り (二層構造) があり, 先天的にしなやかでない髪はそれらが混在して分布することを見出した。また, それによってしなやかな髪は, 表層は柔軟で内層は弾力がある「二層状態の物性」をもつことがわかった。われわれは, この表層と内層との物性差が, 柔らかさと弾力性の共存する, しなやかな髪の特徴的な性質であると考えた。さらに本研究では, しなやかでない髪をしなやかな髪に近づける一つの方法として, コハク酸によって, 毛髪表層を選択的に柔軟化し, 「二層状態の物性」に改質することに成功したので報告する。
Optimization of Transfection of Human Endothelial Cells (1997)

Recently developed transfection methods for mammalian cells provide a powerful means for the study of gene function. Unfortunately, human endothelial cells were relative refractory to the classic transfection techniques. In this study we compared the usability of calcium phosphate, DEAE-dextran transfection, transferrinfection, lipofection, and electroporation for the transfection of early passage HUVECs and for the human endothelial cell lines ECV 304 and EA.hy 926. The classic transfection methods resulted in no or only marginal expression of the reporter gene E. coli beta-galactosidase. For lipofection experiments we compared the commercially available liposome formulations DOTAP and Transfectam with liposomes prepared of dimethyldioctadecylammoniumbromide (DDAB) or 1,2-dimyristyloxypropyl-3-dimethylhydroxyethyl ammonium bromide (DMRIE) as the cationic lipid compound and dioleylphosphatidylethanolamine (DOPE) or Azolectin (a crude fraction of soybean lipids, commercially available as phosphatidylcholine II) as neutral co-lipid. Because the protocol for the chemical synthesis of DMRIE has not been published yet, we developed a protocol for the chemical synthesis of this cationic lipid. With transfection protocols optimized for each cell line, we could achieve transfection efficiencies up to 2%. Compared to the other methods used, the lipofection proved to be a reliable technique for the efficient transfection of the human endothelial cell lines ECV 304 and EA.hy 926. Although we achieved a maximum transfection efficiency of 0.45% for the lipofection of HUVEC, the electroporation seemed to be the better choice for these cells.
Stretchable Substrates for the Measurement of Intracellular Calcium Ion Concentration Responding to Mechanical Stress (2009)

This paper presents the design, fabrication, and the characterization of a stretchable substrate, achieving the change of intracellular calcium ion concentration by mechanical stress. We propose the stretchable substrate integrated with the air chambers of the pneumatic actuator. We have measured the areal strain depending on input pressure and the intracellular calcium ion concentration increase in response to the mechanical stress. The present stretchable substrate is able to provide the areal strain of 5.21% ~ 12.3% for the input pressure of 34.5 kPa ~ 103 kPa. We also verified that the present stretchable substrate is able to stimulate cells by the mechanical stress applied through integrins, showing potential feasible application for monitoring the calcium ion influx caused by the mechanical stress.
Integrated Switch for Mode-Division Multiplexing (MDM) and Wavelength-Division Multiplexing (WDM) (2015)

We demonstrate the first integrated switch for mode-division multiplexing (MDM) and wavelength-division multiplexing (WDM). We show on-chip routing of four 10 Gb/s channels with &lt;−20 dB crosstalk and 0.5-1.4 dB power penalty.
A Computational Model of Cardiovascular Physiology and Heart Sound Generation (2009)

A computational model of the cardiovascular system is described which provides a framework for implementing and testing quantitative physiological models of heart sound generation. The lumped-parameter cardiovascular model can be solved for the hemodynamic variables on which the heart sound generation process is built. Parameters of the cardiovascular model can be adjusted to represent various normal and pathological conditions, and the acoustic consequences of those adjustments can be explored. The combined model of the physiology of cardiovascular circulation and heart sound generation has promise for application in teaching, training and algorithm development in computer-aided auscultation of the heart.
Endogenous Inhibin Suppresses Only Basal Follicle- Stimulating Hormone Secretion but Suppresses All Parameters of Pulsatile Luteinizing Hormone Secretion in the Diestrous Female Rat (1989)

The purpose of these studies was to ascertain which parameters of pulsatile gonadotropin secretion are regulated by endogenous inhibin in the intact diestrous female rat. This was determined by examining the changes in the secretion parameters of FSH and LH that resulted from immunoneutralizing endogenous inhibin in diestrous I female rats. Passive immunoneutralization of endogenous inhibin was achieved using specific, high titer ovine antiserum generated against the asubunit of the recently described inhibin molecule. The optimal times after inhibin immunoneutralization to observe the changes in FSH secretion were determined in initial experiments. Pulsatile secretion of both FSH and LH was observable in the diestrous female. Two hours after inhibin immunoneutralization, the mean trough level, mean peak level, and overall mean level of FSH began to increase. The maximal increase and plateau of these parameters were observed 5 h after antiserum injection. During the period of increase, mean FSH pulse amplitude was also increased, but returned to the level observed in control (normal sheep serum-injected) animals when the parameters of trough, peak, and overall mean FSH reached their plateau levels. FSH pulse frequency was not changed at any time. These results indicate that endogenous inhibin affects only the basal parameters of FSH secretion without affecting pulsatile FSH secretion. The transient increase in FSH pulse amplitude resulted from FSH pulses being superimposed on the increasing basal FSH secretion. In contrast, immunoneutralization of endogenous inhibin rapidly increased all parameters (i.e. pulse amplitude and frequency, mean trough and peak levels, and mean plasma levels) of LH secretion. In addition, pituitary sensitivity to an exogenous LHRH challenge was increased in inhibin-immunoneutralized females in terms of stimulated LH secretion. As a result of the already increased rate of basal secretion, the actual quantity of FSH released in response to the LHRH challenge was greatly increased in the inhibin-immunoneutralized rats compared with the normal sheep serum-injected controls; however, the increase in the rate of FSH secretion stimulated by the LHRH challenge was the same in both groups. The observations from these studies collectively demonstrate that inhibin acts endogenously to suppress those parameters of gonadotropin secretion that are regulated by LHRH.(Endocrinology124: 2944-2953, 1989)
Engineering Rhynchostylis retusa-like heterostructured α-nickel molybdate with enhanced redox properties for high-performance rechargeable asymmetric supercapacitors (2019)

<italic>Rhynchostylis retusa</italic>-like α-NiMoO<sub>4</sub> was synthesized using a simple, single-step, and cost-effective wet-chemistry approach, and it exhibited the superior electrochemical properties.
Data from Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Mixed bacterial vaccine (MBV, Coley's toxins) is a historical, vaguely defined preparation of heat-inactivated &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; and &lt;i&gt;Serratia marcescens&lt;/i&gt; used as nonspecific immunotherapy in the treatment of cancer. The mechanism of action is suspected to have an immunologic basis, yet it is poorly defined up to now. We developed a new, biochemically well defined and current good manufacturing practice–compliant MBV preparation, which has been investigated in patients with NY-ESO-1 expressing cancers.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients received MBV subcutaneously at a starting dose of 250 EU (endotoxin units) twice a week. The MBV dose was escalated in each patient until a body temperature of 38°C to 39.5°C was induced or up to the maximum dose of 547.000 EU. Changes in serum cytokine levels were determined and immune responses to NY-ESO-1 were evaluated. Tumor response was assessed according to RECIST.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Twelve patients were enrolled and 11 of them developed fever after the administration of MBV. Ten of 12 patients showed a consistent increase in serum IL-6 levels with the highest levels coinciding with the highest body temperature. A subgroup of patients showed increasing levels of TNF-α, IFN-γ, and IL1-β. A patient with metastatic bladder cancer showed a partial tumor response strongly correlated with MBV-induced fever and highly elevated levels of several cytokines.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; MBV at fever-inducing dose levels can lead to a massive induction of immunoregulatory cytokines that may be involved in inducing tumor regressions. We propose to further explore the role of MBV as a potent immune modulator at higher dose levels and in conjunction with antigen-specific cancer vaccines. &lt;i&gt;Clin Cancer Res; 18(19); 5449–59. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Multi-Party Privacy-Preserving Set Intersection with Quasi-Linear Complexity. (2010)

Secure computation of the set intersection functionality allows n parties to find the intersection between their datasets without revealing anything else about them. An efficient protocol for such task could have multiple potential applications, in commerce, health-care, and security. However, all currently known secure set intersection protocols for n > 2 parties have computational costs that are quadratic in the (maximum) number of entries in the dataset contributed by each party, rendering secure computation of set intersection impractical on anything but small datasets. In this paper we describe the first multi-party protocol for securely computing the set intersection functionality with both the communication and the computation costs that are quasi-linear in the size of the datasets. Specifically, our protocols require O(nkλ) bits of communication and O(nλ + (nλ + n)k) group multiplications per player in the malicious adversary setting, where k is the size of each dataset and λ is security parameter. Our protocol follows the basic idea of the protocol proposed by Kissner and Song [16], but we gain efficiency by using different representation of the polynomials associated with users’ datasets, and careful employment of algorithms that interpolate or evaluate polynomials on multiple points more efficiently.
Welcome note (2013)

Dear Friends and Colleagues, with great pleasure I like to welcome you to the IEEE International Semiconductor Conference Dresden Grenoble 2013 (ISCDG 2013) taking place in Dresden. The objective of the ISCDG is to enhance the visibility of international excellence of the European players in micro- and nanoelectronics.
Digital signal splitting among multiple DACs for analog bandwidth interleaving (ABI) (2016)

A novel concept called analog bandwidth interleaving (ABI) has been recently introduced in order to overcome bandwidth limitations of digital-to-analog converters (DACs) by interleaving the output signals of multiple DACs in the frequency domain. We present for the first time the fundamental interdependencies between bandwidth, sample rate, the number of samples, and the local oscillator frequencies for ABI-DACs. Furthermore, a mathematical expression for the splitting of the digital signal among multiple DACs is presented. Simulations for an exemplary ABI-DAC highlight the interdependencies between the system parameters and difficulties concerning integer solutions.
CCDC 825957: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Does the Facile Reductive Rearrangement of 2-Allyloxycyclohexenone with Bu3SnH Occur by a Radical-Accelerated Claisen Rearrangement or a Stannyloxy-Accelerated Claisen Rearrangement? (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDoes the Facile Reductive Rearrangement of 2-Allyloxycyclohexenone with Bu3SnH Occur by a Radical-Accelerated Claisen Rearrangement or a Stannyloxy-Accelerated Claisen Rearrangement?Dennis P. Curran and Yoshinori NishiiView Author Information Department of Chemistry, University of Pittsburgh Pittsburgh, Pennsylvania 15260 Cite this: J. Am. Chem. Soc. 1999, 121, 38, 8955–8956Publication Date (Web):September 8, 1999Publication History Received19 May 1999Published online8 September 1999Published inissue 1 September 1999https://doi.org/10.1021/ja991663nCopyright © 1999 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views300Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (119 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Ethers,Molecular structure,Rearrangement,Redox reactions Get e-Alerts
Vaccines for other neonatal infections: Neonatal BCG vaccination against tuberculosis (2004)

This section focuses on current progress in the use of vaccines against a range of other infectious agents, both bacterial (pertussis, pneumococcus and group B streptococcus) and mycobacterial (bacille Calmette-Guérin) to prevent neonatal infection.
Inverse Multiple Scattering with Phaseless Measurements (2020)

We study the problem of reconstructing an object from phaseless measurements in the context of inverse multiple scattering. Our formulation explicitly decouples the variables that represent the unknown object image and the unknown phase, respectively, in the forward model. This enables us to simultaneously optimize over both unknowns with appropriate regularization for each. The resulting optimization problem is nonconvex due to the nonlinear propagation model for multiple scattering and the nonconvex regularization of the phase variables. Nevertheless, we demonstrate experimentally that we can solve the optimization problem using a variation of the fast iterative shrinkage-thresholding algorithm (FISTA)-a convex algorithm, popular for its speed and simplicity-that converges well in our experiments. Numerical results with both simulated and experimentally measured data show that the proposed method outperforms the state-of-the-art phaseless inverse scattering method.
Younger age and early puberty are associated with cognitive function decline in children with Cushing disease (2021)

Our findings suggest that chronic glucocorticoid excess and accompanying secondary hormonal imbalances followed by eucortisolemia have detrimental effects on cognitive function in the developing brain; younger age and pubertal stage are risk factors for increased vulnerability, while older adolescents have cognitive vulnerabilities like that of adult patients affected with CD.
Datasets for gene expression profiles of head and neck squamous cell carcinoma and lung cancer treated or not by PD1/PD-L1 inhibitors (2022)

Identification of tumors harboring an overall active immune phenotype may help for selecting patients with advanced head and neck squamous cell carcinomas (HNSCC) and non-small cell lung cancer (NSCLC) who may benefit from immunotherapies. In this context, we generated targeted gene expression profiles in three and two independent cohorts of patients with HNSCC or NSCLC respectively, treated or not by PD-1/PD-L1 inhibitors. Notably, we generated two datasets including 102 and 82 patients with HNSCC or NSCLC treated with PD-1/PD-L1 inhibitors. Clinical information, including detailed survival raw data, is available for each patient, allowing to test association between gene expression data and patient survival (overall and progression-free survival). Moreover, we also generated gene expression datasets of 27 paired HNSCC samples from diagnostic biopsies and versus surgically resected specimens as well as 33 paired HNSCC samples at initial diagnosis (untreated) and at recurrence. Those datasets may allow to test the stability of a given biomarker across paired samples.
A 3D Model for Eddy Current Inspection in Aeronautics: Application to Riveted Structures (2007)

Eddy current technique is currently an operational tool used for fastener inspection which is an important issue for the maintenance of aircraft structures. The industry calls for faster, more sensitive and reliable NDT techniques for the detection and characterization of potential flaws nearby rivet. In order to reduce the development time and to optimize the design and the performances assessment of an inspection procedure, the CEA and EADS have started a collaborative work aiming at extending the modeling features of the CIVA non destructive simulation plat‐form in order to handle the configuration of a layered planar structure with a rivet and an embedded flaw nearby. Therefore, an approach based on the Volume Integral Method using the Green dyadic formalism which greatly increases computation efficiency has been developed. The first step, modeling the rivet without flaw as a hole in a multi‐stratified structure, has been reached and validated in several configurations with experimental data.
Flux, Position, and Velocity Estimation in AC Machines at Zero and Low Speed via Tracking of High Frequency Saliencies (1999)

Achieving transducerless (sensorless) control of a.c. machines that is robust during sustained operation at or near zero speed (i.e. zero excitation frequency) is exceedingly difficult. This paper presents an elegantly simple and viable, generalized approach to achieving robust, accurate transducerless state estimation in polyphase a.c. machines, including the estimation of flux. position, and velocity in induction and synchronous machines at zero and low speeds. It is based upon the tracking of magnetic saliencies via inverter-generated high-frequency signal injection with demodulation incorporating heterodyning and a closed-loop observer. The saliencies may be saturation-induced, thus yielding a means of direct flux position estimation, or rotor-constructed and thus yielding rotor position and velocity estimation. Experimental results are provided demonstrating rotor position estimation with a permanent magnet synchronous motor.