gebhart/patrepeval huggingface dataset:
NEO1 and NEO-EXT Studies: Long-Term Safety and Exploratory Efficacy of Repeat Avalglucosidase Alfa Dosing for 5.5 Years in Late-Onset Pompe Disease Patients (695) (2020)

To evaluate long-term effects of avalglucosidase alfa in late-onset Pompe disease patients in NEO-EXT (NCT02032524), an ongoing extension of NEO1 (NCT01898364).
Rule Induction in Knowledge Graphs Using Linear Programming (2021)

We present a simple linear programming (LP) based method to learn compact and interpretable sets of rules encoding the facts in a knowledge graph (KG) and use these rules to solve the KG completion problem. Our LP model chooses a set of rules of bounded complexity from a list of candidate first-order logic rules and assigns weights to them. The complexity bound is enforced via explicit constraints. We combine simple rule generation heuristics with our rule selection LP to obtain predictions with accuracy comparable to state-of-the-art codes, even while generating much more compact rule sets. Furthermore, when we take as input rules generated by other codes, we often improve interpretability by reducing the number of chosen rules, while maintaining accuracy.
Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers (2021)

Treatment of cancers in the lung remains a critical challenge in the clinic for which gene therapy could offer valuable options. We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under the control of the cancer-selective progression elevated gene 3 (PEG-3) promoter, to treat tumors in the lungs of diseased mice. A clinically tested, untargeted, polyethylenimine carrier was selected to aid rapid transition to clinical studies, and a CpG-free plasmid backbone and coding sequences were used to reduce inflammation. Intravenous administration of nanoparticles expressing murine single-chain interleukin 12, under the control of PEG-3 promoter, significantly improved the survival of mice in both an orthotopic and a metastatic model of lung cancer with no marked symptoms of systemic toxicity. These outcomes achieved using clinically relevant nanoparticle components raises the promise of translation to human therapy.
The Antitumor Peptide CIGB-552 Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells (2013)

We have demonstrated that the peptide L-2 designed from an alanine scanning of the Limulus -derived LALF32-51 region is a potential candidate for the anticancer therapy and its cell-penetrating capacity is an associated useful property. By the modification in the primary structure of L-2, a second-generation peptide (CIGB-552) was developed. However, the molecular mechanism underlying its cytotoxic activity remains partially unknown. In this study, it was shown that CIGB-552 increases the levels of COMMD1, a protein involved in copper homeostasis, sodium transport, and the NF- κ B signaling pathway. We found that CIGB-552 induces ubiquitination of RelA and inhibits the antiapoptotic activity regulated by NF- κ B, whereas the knockdown of COMMD1 blocks this effect. We also found that CIGB-552 decreases the antioxidant capacity and induces the peroxidation of proteins and lipids in the tumor cells. Altogether, this study provides new insights into the mechanism of action of the peptide CIGB-552, which could be relevant in the design of future anticancer therapies.
The determination of von Willebrand factor activity by collagen binding assay (1998)

A new collagen binding assay has been developed for the determination of the functional activity of human von Willebrand factor based on the following principle: pepsin-digested type III collagen from human placenta was covalently immobilized on a microtitre plate. Binding of collagen to the microtitre plate was carried out in neutral phosphate buffer within 1 h. A collagen concentration of 3 micrograms mL-1 was sufficient to achieve optimal coating. After drying, the coated microtitre plates remained stable for months without losing their vWF-binding properties and could be incorporated into a ready-to-use kit. The suitability of various types of collagen for use in this assay was evaluated by simulating the binding of vWF to collagen immobilized on the microtitre plate by using surface plasmon resonance technology with collagen immobilized on a sensor chip. vWF was most effectively bound to pepsin-digested type III collagen from human placenta. The assay thus comprises the following steps: (1) serial dilutions of a vWF reference preparation and vWF-containing samples are prepared and bound to a microtitre plate which is precoated with collagen; (2) vWF is detected with a polyclonal antibody; (3) the substrate reaction is photometrically measured with an ELISA reader. This test is highly specific and sensitive for vWF (detection limit: 10 ng mL-1). The collagen binding activity measured corresponds to the degree of multimerization of vWF. The high sensitivity and the short time needed to carry it out may make it useful for clinical diagnosis and for the measurement of the functional activity of vWF in factor concentrates. In certain applications it may represent a suitable replacement for the ristocetin cofactor assay.
Speech Translation and the End-to-End Promise: Taking Stock of Where We Are (2020)

Over its three decade history, speech translation has experienced several shifts in its primary research themes; moving from loosely coupled cascades of speech recognition and machine translation, to exploring questions of tight coupling, and finally to end-to-end models that have recently attracted much attention. This paper provides a brief survey of these developments, along with a discussion of the main challenges of traditional approaches which stem from committing to intermediate representations from the speech recognizer, and from training cascaded models separately towards different objectives.
Explanation for positive voltage-current characteristics in weakly ionized, low-pressure gas discharge plasmas (2002)

Summary form only given. Electric discharge plasmas are generally said to have a "negative V-I (voltage-current) characteristic," which is an informal statement that the voltage across the discharge tends to decrease as the current is increased. For this reason discharges cannot normally be stably powered by ordinary voltage sources. However, there are instances in the literature of positive V-I characteristics in the positive column itself which cannot be attributed to the usual suspects: electrode phenomena, species segregation, high ionization fraction, and so on. The author discusses this topic briefly.
Corrosion Studies on Austenitic Stainless Uranus S1N steels under Nuclear Fuel Dissolution Conditions (2016)

International audience
<title>Packaging issues for free-space optically interconnected multiprocessors</title> (1991)

The technical feasibility and the performance of packaged systems with free space optical interconnections for parallel computing are analyzed. System issues such as volume power consumption optical properties of interconnection elements yield problems and noise limitations are considered and their dependence on the existing and future technological constraints are outlined.
Performance Enhancement of ICN-Based Single-Stage AC–DC Converters Using Reconfigurable Inverters (2022)

This article presents a reconfigurable inverter design for the recently proposed impedance control network (ICN) based single-stage ac–dc converters, targeting improvement in their efficiency and power density. This reconfigurable-inverter design effectively compresses the range of input voltages to the ICN converter by operating its two inverters in parallel at low line and in a stacked fashion at high line input. In addition to retaining the wide range zero voltage switching and near zero current switching operation characteristic of the ICN converter, the proposed reconfigurable inverter design benefits all the converter's transistors and magnetic components as it simultaneously reduces the peak voltage stress on its inverter transistors, rms currents through its rectifier transistors, the resonant inductance requirement, and the step-down burden on its transformer, thus improving the overall performance. A novel active voltage balancing scheme for the stacked mode of operation of the two inverters is also proposed. An enhanced version of this active voltage balancing strategy is also discussed, which ensures soft-switching of the inverter transistors by deliberately introducing slight inverter voltage imbalances of appropriate magnitude. A universal-input (90–265 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ), 20-V output, 330-W, 300-kHz reconfigurable-inverter-based ICN ac–dc converter prototype is built and tested. This prototype achieves a power density of 44.5 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , and peak efficiencies of 94% at low line (120 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ) and 93.8% at high line (230 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> ). Compared to the basic ICN converter prototype, this prototype achieves 17% higher power density and has 23% and 9% less loss at low and high line input, respectively.
ChemInform Abstract: NAPHTHOQUINONES FROM ALKYNES AND CHROMIUM‐CARBENE COMPLEXES. CONTROL OF REGIOSELECTIVITY THROUGH INTRAMOLECULAR REACTION (1982)

Abstract Phenyllithium (I) reagiert mit Chromhexacarbonyl (II) zu einem Li‐Salz (IIIa), das in das Tetrabutylammonium‐ Derivat (IIIb) übergeführt und dann zu den verbrückten Naphthohydrochinonen (I‐V) umgesetzt werden kann.
Effect of Whole Body Vibration Training on Lower Limb Performance in Selected High-Level Ballet Students (2007)

The aim of this study was to examine the effects of 8 weeks of whole body vibration (WBV) training on vertical jump ability (CMJ) and knee-extensor performance at selected external loads (50, 70, and 100 kg; leg-press exercise) in elite ballerinas. Twenty-two (age, 21.25 +/- 1.5 years) full-time ballerinas were assigned randomly to the experimental (E, n = 11) and control (C, n = 11) groups. The experimental group was submitted to WBV training 3 times per week before ballet practice. During the training period, the E and C groups undertook the same amount of ballet practice. Posttraining CMJ performance significantly increased in E group (6.3 +/- 3.8%, p < 0.001). Furthermore, E group showed significant (p < 0.05-0.001) posttraining average leg-press power and velocity improvements at all the external loads considered. Consequently, the force-velocity and power-velocity relationship shifted to the right after WBV training in the E group. The results of the present study show that WBV training is an effective short-term training methodology for inducing improvements in knee-extensor explosiveness in elite ballerinas.
Genetic aspects of the biology of schizophrenia (1992)

Linkage studies aimed at identifying the chromosomal loci for genes involved in schizophrenia continue to yield conflicting results. However, investigation of the optimal size and structure of pedigrees, more consistent ways of using diagnostic schema, newer highly informative probes and an international collaboration between researchers should enhance the ability to detect linkage. Important studies have also emerged that use methods complementary to linkage, such as the direct examination of candidate genes and the investigation of cytogenetic abnormalities that cosegregate with illness.
ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of New 3‐Substituted Carbamoyloxymethyl Cephalosporins. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions (2017)

This study provides a framework for understanding the structure of colloidal phases, and it may assist in elucidating the role of dosing conditions on drug absorption from the distal ileum and caecum.
In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian Cancer (2009)

The second generation of pH-sensitive micelles composed of poly(l-histidine-co-l-phenlyalanine(16 mol %))(MW:5K)-b-PEG(MW:2K) and poly(l-lactic acid)(MW:3K)-b-PEG(MW:2K)-folate (80/20 wt/wt %) was previously optimized by physicochemical and in vitro tests for both folate receptor and early endosomal pH targeting (pH approximately 6.0). In this study, the therapeutic efficacy of the doxorubicin (DOX)-loaded micelles (DOX loading content: 20 wt %) was evaluated using in vivo tests. Multidrug-resistant (MDR) ovarian tumor-xenografted mouse models were employed. The skin-fold dorsal window chamber model was applied for visualization of extravasation and drug retention for the initial one hour after iv injection. Noninvasive imaging followed, providing evidence of drug accumulation in the tumor after the first hour. The biodistribution study further supported the long circulation of the drug carrier, tumor-selective accumulation and intracellular drug delivery. Comprehensive tumor growth inhibition experiments examined the collective efficacy of the pH-sensitive micelles. The micelle formulation effectively suppressed the growth of existing MDR tumors in mice for at least 50 days by three iv injections at a 3-day interval at a dose of 10 mg of DOX/kg. The body weight of the animals treated with the test micelle formulation gradually increased over the experimental time period, rather than decreasing. The micelle formulation was superior to its first generation, which targeted pH 6.8 and folate receptor.
Dancing in the Streets: The design and evaluation of a wearable health game (2010)

Obesity is a worldwide epidemic, with childhood obesity currently ranking as one of the biggest health challenges facing the United States today. In this project we introduce a mobile and wearable health video game, Dancing in the Streets (DITS). DITS uses two wireless, 3-axis accelerometers as input to a social, mobile, phone-based dancing game played by groups of collocated users. DITS was evaluated by 50 American high school students from two different inner-city public high schools. Each student was trained how to use the system and had the opportunity to play through two different songs. We collected usability and demographic data from the participants. In this paper, we present the design of the system and the results of our evaluation.
Service quality assurance for the IPTV networks (2013)

The objective of the proposed research is to design and evaluate end-to-end solutions to support the Quality of Experience (QoE) for the Internet Protocol Television (IPTV) service. IPTV is a system that integrates voice, video, and data delivery into a single Internet Protocol (IP) framework to enable interactive broadcasting services at the subscribers. It promises significant advantages for both service providers and subscribers. For instance, unlike conventional broadcasting systems, IPTV broadcasts will not be restricted by the limited number of channels in the broadcast/radio spectrum. Furthermore, IPTV will provide its subscribers with the opportunity to access and interact with a wide variety of high-quality on-demand video content over the Internet. However, these advantages come at the expense of stricter quality of service (QoS) requirements than traditional Internet applications. Since IPTV is considered as a real-time broadcast service over the Internet, the success of the IPTV service depends on the QoE perceived by the end-users. The characteristics of the video traffic as well as the high-quality requirements of the IPTV broadcast impose strict requirements on transmission delay. IPTV framework has to provide mechanisms to satisfy the stringent delay, jitter, and packet loss requirements of the IPTV service over lossy transmission channels with varying characteristics. The proposed research focuses on error recovery and channel change latency problems in IPTV networks. Our specific aim is to develop a content delivery framework that integrates content features, IPTV application requirements, and network characteristics in such a way that the network resource utilization can be optimized for the given constraints on the user perceived service quality. To achieve the desired QoE levels, the proposed research focuses on the design of resource optimal server-based and peer-assisted delivery techniques. First, by analyzing the tradeoffs on the use of proactive and reactive repair techniques, a solution that optimizes the error recovery overhead is proposed. Further analysis on the proposed solution is performed by also focusing on the use of multicast error recovery techniques. By investigating the tradeoffs on the use of network-assisted and client-based channel change solutions, distributed content delivery frameworks are proposed to optimize the error recovery performance. Next, bandwidth and latency tradeoffs associated with the use of concurrent delivery streams to support the IPTV channel change are analyzed, and the results are used to develop a resource-optimal channel change framework that greatly improves the latency performance in the network. For both problems studied in this research, scalability concerns for the IPTV service are addressed by properly integrating peer-based delivery techniques into server-based solutions.
The cartilaginous and osseous geometry of the femoral trochlear groove (2003)

Abstract Photography was used to study the geometry of the cartilaginous and osseous contours of the distal femur and the orientation of the trochlear groove in 9 fresh‐frozen and 24 embalmed knees. The sulcus angle (146.1°±5.5°) decreased from 0° to 50° of femoral flexion then increased afterwards. The maximum slope of the lateral femoral condyle (20.2°±5.2°) also decreased with flexion. Both the sulcus angle ( p =0.0007) and maximum slope ( p =0.0001) were larger at 0° than they were for 60° cartilaginous surfaces. The lateral femoral condylar height decreased, whilst the medial femoral condylar height increased as the flexion increased. The femoral groove was midway between the two femoral epicondyles (49.5±3.9%), but deviated laterally as the flexion angle increased. The groove axis deviated distally and laterally from the femoral anatomical axis for both cartilaginous and bony surfaces, and the angle between the groove and anatomical axes was similar for both cartilaginous (19.1°) and osseous (16.8°) surfaces. Articular cartilage is not well represented on radiography yet it had a significant effect on the distal femoral geometry, and should be taken into account when evaluating the patellofemoral joint.
Effect of Time Scales on the Unfolding of Neural Attractors (2001)

A study of the effect of time scales in brain dynamics on the unfolding of the attractors in the phase space, reconstructed by a time delay embedding of the EEG signal, was carried out. Applying the techniques of nonlinear time series analysis, the unfolding rate of the system attractor was determined by analyzing the variation of the correlation dimension parameter and subjecting it to a bi-parametric fit. The behavior of the parameter, which measures the rate of unfolding, was monitored for varying time scales in two cases: (a) normal eyes closed condition and (b) the pathological case of epilepsy. Significant results were obtained.
A cross-coupled cmos negative capacitor for wideband metamaterial applications (2014)

Non-Foster circuits can be used to provide broadband impedance matching for antennas and metamaterials. These circuits allow effective matching over a much wider bandwidth than is expected from traditional passive components. Therefore, this paper considers the design and test of a negative capacitor in a 0.5 micron CMOS process. The proposed circuit uses a cross-coupled design to allow for floating operation, and the design's simulated performance works well at high frequency. Measured results show a low-frequency capacitance of -1.7 pF and within 10% to 200 MHz, and falling to -4 pF at 230 MHz. Although the selected CMOS process is adequate to demonstrate the basic design approach, more advanced process nodes would be expected to extend performance to even higher frequencies. Results are also presented showing performance of the circuit in a metamaterial.
Mid-IR DFG frequency combs with high mode power and 1.5 Hz linewidth using femtosecond fiber laser systems (2020)

We present DFG frequency comb systems operating between 3 and 5 pm based on femtosecond Er- and Yb-fiber laser-amplifier systems, providing an average power of up to 250 mW and 31 pW per comb mode with 1.5 Hz optical linewidths in the mid-IR.
Supplementary figures from Detection of T790M, the Acquired Resistance <i>EGFR</i> Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses (2023)

&lt;p&gt;Supplementary Figures S1-S3. Supplementary Figure S1: T790M CTC PointMan genotyping assay. Supplementary Figure S2: T790M concordance by genotyping method. Supplementary Figure S3: Concordance of L858R and Ex 19 deletion genotyping by ctDNA and tissue biopsy.&lt;/p&gt;
A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection (2015)

Burkholderia is a diverse genus of gram-negative bacteria that causes high mortality rate in humans, equines and cattle. The lack of effective therapeutic treatments poses serious public health threats. Developing insights toward host-Burkholderia spp. interaction is critical for understanding the pathogenesis of infection as well as identifying therapeutic targets for drug development. Reverse-phase protein microarray technology was previously proven to identify and characterize novel biomarkers and molecular signatures associated with infectious disease and cancer. In the present study, this technology was utilized to interrogate changes in host protein expression and phosphorylation events in macrophages infected with a collection of geographically diverse strains of Burkholderia spp. The expression or phosphorylation state of 25 proteins was altered during Burkholderia spp. infections of which eight proteins were selected for further characterization by immunoblotting. Increased phosphorylation of AMPK-α1, Src, and GSK3β suggested the importance of their roles in regulating Burkholderia spp. mediated innate immune response. Modulating the inflammatory response by perturbing their activities may provide therapeutic routes for future treatments.