gebhart/patrepeval huggingface dataset:
A security architecture for fault-tolerant systems (1994)

Process groups are a common abstraction for fault-tolerant computing in distributed systems. We present a security architecture that extends the process group into a security abstraction. Integral parts of this architecture are services that securely and fault tolerantly support cryptographic key distribution. Using replication only when necessary, and introducing novel replication techniques when it was necessary, we have constructed these services both to be easily defensible against attack and to permit key distribution despite the transient unavailability of a substantial number of servers. We detail the design and implementation of these services and the secure process group abstraction they support. We also give preliminary performance figures for some common group operations.
Superoxide production of peritoneal macrophages in experimental Gram‐negative sepsis; influence of in vitro and in vivo supplements of zinc (1989)

Although zinc is essential for the optimum function of the immune system, there is some controversy regarding treatment with zinc during acute infections where low serum zinc levels are often recorded. The aim of the present study was to investigate the influence of in vitro and in vivo zinc supplementation on the potentially toxic metabolic activity of peritoneal macrophages during infection. Rats were made septic by implanting a gelatin capsule containing known amounts of E. coli, and Bacteroides fragilis into the abdomen. Peritoneal macrophages were harvested by peritoneal lavage 72 hours after the induction of sepsis. Superoxide release was measured after stimulation with phorbol myristate acetate (PMA) or serum treated zymosan (STZ). Macrophages from septic rats released significantly higher amounts of superoxide compared with macrophages from sham operated controls after stimulation with both PMA and STZ. Following in vitro supplementation, zinc inhibited the superoxide production of macrophages harvested from septic rats after stimulation with both PMA and STZ. In vivo supplementation with zinc resulted in increased superoxide production from septic macrophages when stimulated with STZ, whereas stimulation with PMA produced no significant changes. Thus, in vitro incubation inhibited the superoxide production of peritoneal macrophages in intraabdominal sepsis, whilst in vivo administration of zinc produced no such effect, and the effect seemed to vary depending on the stimuli used to initiate the respiratory burst.
Timestamp support for BGP paths (2015)

BGP is more and more used to transport routing information for
critical services. Some BGP updates may be critical to be received as
fast as possible : for example, in a layer 3 VPN scenario where a
dual-attached site is loosing primary connection, the BGP withdraw
message should be propagated as fast as possible to restore the
service. The same criticity exists for other address-families like
multicast VPNs where join messages should also be propagated very
fast. Experience of service providers shows that BGP path propagation
time may vary depending on network conditions (especially load of BGP
speaker on the path) and too long propagation time are affecting
customer service. It is important for service providers to keep track
of BGP updates propagation time to monitor quality of service for the
customers. It is also important to be able to identify BGP Speakers
that are slowing down the propagation. This document presents a
solution to transport timestamps of a BGP path. The solution is
targeted to be used using special identified beacon prefixes that are
single-homed.
Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G (2003)

Murine monoclonal antibody (mAb) Lym-1 is an immunoglobulin G2a specific for certain human leukocyte antigen-DR variants expressed on the surface of malignant B cells. It has been proposed for serotherapy in patients with B lymphomas. We have previously shown that mAb Lym-1 synergizes with granulocyte macrophage-colony stimulating factor to promote Raji B-lymphoid cell lysis by human neutrophils via the intervention of neutrophil Fc receptors type II and D-mannose-inhibitable interactions between CD11b-CD18 integrins and CD66b glycoproteins. Here, we provide evidence that the process is oxygen-independent by inference related to the release of primary granules and is regulated by cathepsin G activity. The lysis was indeed reproduced by replacing normal neutrophils with cells from three patients suffering from chronic granulomatous disease, i.e., neutrophils genetically incapable of generating oxidants. Moreover, the lysis was inhibited by the serine protease inhibitor 3,4-dichloroisocoumarin and by Z-glycyl-leucyl-phenyl-chloromethyl ketone (Z-Gly-Leu-Phe-CMK), which blocks cathepsin G. Conversely, the lysis was unaffected by N-methoxysuccinyl-alanyl-alanyl-prolyl-alanyl-CMK (MeOSuc-Ala-Ala-Pro-Ala-CMK; elastase inhibitor) and MeOSuc-Ala-Ala-Pro-valine (Val)-CMK, which inhibits elastase and proteinase 3. The ability of neutrophils, engaged in cytolysis, to release cathepsin G was proved by detecting this enzymatic activity spectrophotometrically and immunocytochemically. Moreover, inhibition of cathepsin G activity by concentrations of Z-Gly-Leu-Phe-CMK, incapable of affecting elastase activity, was found to reduce the release of elastase and myeloperoxidase from neutrophils under conditions similar to those used for cytolytic assays. These findings suggest that neutrophils auto-regulate their lytic efficiency by controlling the exocytosis of primary granules via their cathepsin G activity.
Usefulness of Fluorescence in situ Hybridization for the Diagnosis of Turner Mosaic Fetuses with Small Ring X Chromosomes (2000)

Because very small ring X chromosomes can escape identification when standard cytogenetic techniques are used alone, we show that misdiagnosis can be avoided when FISH is performed beforehand.
Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients (2014)

Cystic fibrosis (CF) patients often acquire chronic respiratory tract infections due to Pseudomonas aeruginosa and Burkholderia cepacia complex (Bcc) species. In the CF lung, these bacteria grow as multicellular aggregates termed biofilms. Biofilms demonstrate increased (adaptive) resistance to conventional antibiotics, and there are currently no available biofilm-specific therapies. Using plastic adherent, hydroxyapatite and flow cell biofilm models coupled with confocal and scanning electron microscopy, it was demonstrated that an anti-biofilm peptide 1018 prevented biofilm formation, eradicated mature biofilms and killed biofilms formed by a wide range of P. aeruginosa and B. cenocepacia clinical isolates. New peptide derivatives were designed that, compared to their parent peptide 1018, showed similar or decreased anti-biofilm activity against P. aeruginosa biofilms, but increased activity against biofilms formed by the Gram-positive bacterium methicillin resistant Staphylococcus aureus. In addition, some of these new peptide derivatives retained the immunomodulatory activity of 1018 since they induced the production of the chemokine monocyte chemotactic protein-1 (MCP-1) and suppressed lipopolysaccharide-mediated tumor necrosis factor-α (TNF-α) production by human peripheral blood mononuclear cells (PBMC) and were non-toxic towards these cells. Peptide 1018 and its derivatives provide promising leads for the treatment of chronic biofilm infections and hyperinflammatory lung disease in CF patients.
Tissue specific variants of glutamate transporter GLT‐1 (1997)

cDNA cloning of glutamate transporter GLT-1 from mouse brain and liver has revealed that 5'-ends of the messages are different between brain and liver. In addition, one of the GLT-1 cDNAs isolated from liver has been found to possess a 3'-end different from those of the others. Reverse transcription polymerase chain reaction (RT-PCR) amplification using primers specific for altered 5'-ends has confirmed that brain and liver messages possess their own specific 5'-ends. Both of the two 3'-ends have been demonstrated by RT-PCR to be present not only in liver but also in brain, indicating both brain and liver GLT-1 possess two types of 3'-ends. Although functional properties are not changed by the alteration of N-termini and C-termini when expressed in Xenopus laevis oocytes, co-expression of two liver type GLT-1 with different C-termini (mGLT-1A and mGLT-1B) has been found to result in the increase in Vmax of transport without changing Km. These results suggest the tissue specific alternative splicing at 5'-ends of GLT-1 messages and the interesting association of spliced variants with different C-termini.
Correlation preserving map between bipartite states and temporal\n evolutions (2011)

The Hilbert space formalism of quantum theory manifests a map between\nbipartite states and time evolutions, known as Jamiolkowski isomorphism. We\nextend this map in a physical setting to prove the equality of spatial\ncorrelations in bipartite systems and temporal correlations in local systems.\nWe show that these correlations can be observed using weak measurements. This\nresult has several practical and conceptual implications such as manifestation\nof state independent decoherence, the correspondence between Bell and\nLeggett-Garg inequalities, multipartite systems, the statistical properties of\nevolutions in large systems, and computational gain, in evaluation of spatial\ncorrelations in large systems.\n
Free radical polymerizations for narrow polydispersity resins: electron spin resonance studies of the kinetics and mechanism (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree radical polymerizations for narrow polydispersity resins: electron spin resonance studies of the kinetics and mechanismRichard P. N. Veregin, Michael K. Georges, Peter M. Kazmaier, and Gordon K. HamerCite this: Macromolecules 1993, 26, 20, 5316–5320Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ma00072a007https://doi.org/10.1021/ma00072a007research-articleACS PublicationsRequest reuse permissionsArticle Views1069Altmetric-Citations219LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural characterization of bimetallic nanomaterials with overlapping x-ray absorption edges (2009)

We describe a data analysis method for extended x-ray absorption fine structure spectroscopy suitable for use with compounds of diverse form that contain overlapping absorption edges. This method employs direct concurrent analysis of the data---demonstrated here for cases involving two interfering metal edges---and does not utilize subtractive or data filtering strategies that have been previously used to address this challenge. Its generality and precision are demonstrated in analyses made on two model nanoscale samples: (1) a Ir-Pt nanoparticle system supported on $\ensuremath{\gamma}{\text{-Al}}_{2}{\text{O}}_{3}$ and (2) a hybrid system of Pt nanowires on which Au nanoparticles have been nucleated and grown at the nanowire tips, stacking faults, and twinning boundaries. The results obtained demonstrate the unique compositional and structural qualities of these two systems as well as the broader utility of the new x-ray absorption spectroscopy based protocol used to characterize them.
Adaptive Learning for Symbol Detection (2019)

This chapter introduces a novel machine learning algorithm for symbol detection in multiuser environments. It considers a challenging multiuser uplink scenario in which the number of antennas available at the base station may be smaller than the number of active users. More specifically, the proposed method is an adaptive (nonlinear) receive filter that learns to detect symbols from data directly, without performing any intermediate estimation tasks (e.g. channel estimation). Furthermore, the method is robust against abrupt changes of the wireless environment. The proposed algorithms for symbol detection are based on the theory of reproducing kernel Hilbert spaces, which have been extensively used in diverse fields such as statistics, probability, signal processing, and machine learning, among others. It also discusses the adaptive learning method for symbol detection in multiuser environments.
Fabrication of metallic hard mold for polymeric waveguides with embedded micro-mirrors (2010)

In this paper, we presented fabrication of nickel metal mold with 45° tilted surfaces on both waveguide ends through electroplating process. To obtain 45° angle, SU-8 was exposed under D.I. water, with repeatable 0.5° error.
Treatment of Former Smokers With 9-cis-Retinoic Acid Reverses Loss of Retinoic Acid Receptor- Expression in the Bronchial Epithelium: Results From a Randomized Placebo-Controlled Trial (2003)

9-cis-RA treatment can restore RAR-beta expression in the bronchial epithelium of former smokers, raising the possibility that this retinoid has potential chemopreventive properties in former smokers.
Raman spectroscopic investigation of chromium(VI) equilibria — another look (1999)

Quantitative Raman intensity data for aqueous CrVI solutions were obtained with the object of modelling the equilibria involved. Raman scattering data for two series of chromate(VI) solutions containing 12 and 18 mM CrVI, in the pHc range ca 3–10 (0.10 M NaCl), were subjected to computer modelling calculations using the program PHAB. The model which assumes that CrO42− undergoes protonation to HCrO4− (log β11 = 6.01 ± 0.24) and condensation to Cr2O72− (log β22 = 13.87 ± 0.36) can be fitted better to the experimental intensity data than one which ignores HCrO4−. Copyright © 1999 John Wiley & Sons, Ltd.
Online chromatic dispersion monitoring and compensation using a single inband subcarrier tone (2002)

In this letter, we demonstrate a simple technique for dispersion monitoring by adding a single inband subcarrier tone to the transmitted data signal. A measurable dispersion of up to 1200 ps/nm is demonstrated in a 10-Gb/s channel using a 7-9 GHz subcarrier and the addition of the subcarrier induced a power penalty of <0.5 dB. Dynamic ranges exceeding 20 dB and resolution sensitivities better than 10 (ps/nm)/dB are shown. With an 8-GHz tone and a 15% modulation depth for 10-Gb/s signals, we show a measurement range of 975 ps/nm with a 22-dB dynamic range. We used the monitor output signal to achieve accurate tunable dispersion compensation.
Development of a novel method to measure the elastic properties of skin including subcutaneous tissue: New age‐related parameters and scope of application (2008)

This apparatus differs from other conventional instruments in that it measures the elastic properties of skin including subcutaneous tissue without contact.
Analysis of Extracellular Vesicles Using Coffee Ring (2018)

Extracellular vesicles are categorized in subsets according to their biogenesis processes. To facilitate the investigation of subsets, an effective method is needed for isolating subpopulations. The efficacy of existing density and size-based isolation methods is limited, and as a result, the correlation of properties within separated subpopulations is modest. Here, we introduced size separation with ∼48 nm resolution that exploits Marangoni flow and the coffee-ring effect in microdroplets in which extracellular vesicles are spatially deposited at different location according to size of extracellular vesicle. Interestingly, the analysis of tetraspanin proteins of the extracellular vesicles facilitated by this method reveals that the size of extracellular vesicles is correlated with expression of tetraspanin proteins (CD9, CD63, CD81) that are associated with the size of extracellular vesicles. The findings show that CD9 and CD81 are uniformly expressed regardless of size, CD63 is highly expressed only in larger extracellular vesicles. This evidence indicates that extracellular vesicles can be classified based on size and expression of CD63.
Stability of Hybrid-Wing-Body-Type Aircraft with Centerbody Leading-Edge Carving (2010)

The silent-aircraft experimental aircraft are balanced by generating lift near the aircraft nose through leading-edge carving of the centerbody. The use of leading-edge carving over the centerbody is novel, in that previous blended-wing-body aircraft have balanced the aircraft by downloading the centerbody (via reflex camber) to achieve the effect of a tail. This paper decomposes the aerodynamic forces into contributions from spanwise sections to explain how three-dimensional flow effects are beneficial in allowing the silent-aircraft experimental aircraft to be both statically stable and to have an elliptical lift distribution over a large range of angles of attack. By analyzing the results in this manner, rationale is also given as to why, unlike other blended-wing-body-type configurations, the silent-aircraft-experimental design can use supercritical unstable-outer-wing airfoil profiles to generate a balanced and stable aircraft. The results are then used to develop a methodology to aid the aircraft designer in determining the amount of leading-edge carving that is necessary to achieve static stability for blended-wing-body-type aircraft.
ADHD-LIKE BEHAVIOURAL PROFILE IN DOGS WITH IDIOPATHIC EPILEPSY (2015)

BackgroundHypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans. ObjectivesCharacterize capillary rarefaction in cats with chronic kidney disease (CKD). AnimalsArchival kidney tissue from 58 cats with CKD, 20 unaffected cats. MethodsCross-sectional study of paraffin-embedded kidney tissue utilizing CD31 immunohistochemistry to highlight vascular structures. Consecutive high-power fields from the cortex (10) and corticomedullary junction (5) were digitally photographed. An observer counted and colored the capillary area. Image analysis was used to determine the capillary number, average capillary size, and average percent capillary area in the cortex and corticomedullary junction. Histologic scoring was performed by a pathologist masked to clinical data. ResultsPercent capillary area (cortex) was significantly lower in CKD (median 3.2, range, 0.8-5.6) compared to unaffected cats (4.4, 1.8-7.0; P = <.001) and was negatively correlated with serum creatinine concentrations (r = -.36, P = .0013), glomerulosclerosis (r = -0.39, P = <.001), inflammation (r = -.30, P = .009), and fibrosis (r = -.30, P = .007). Capillary size (cortex) was significantly lower in CKD cats (2591 pixels, 1184-7289) compared to unaffected cats (4523 pixels, 1801-7618; P = <.001) and was negatively correlated with serum creatinine concentrations (r = -.40, P = <.001), glomerulosclerosis (r = -.44, P < .001), inflammation (r = -.42, P = <.001), and fibrosis (r = -.38, P = <.001). Conclusions and Clinical ImportanceCapillary rarefaction (decrease in capillary size and percent capillary area) is present in kidneys of cats with CKD and is positively correlated with renal dysfunction and histopathologic lesions.
High power single lateral mode diode lasers (2003)

Novel waveguide structures are presented that facilitate high power, single lateral mode output in narrow stripe semiconductor lasers. Flared tapered waveguide lasers, fabricated by a metal-organic chemical vapor deposition (MOCVD) selective area epitaxy (SAE), are shown to attain output powers of 650mW with stable single lateral mode beam properties. Novel integrated mode filters, which induce mode selective lateral radiation loss via curvature, or frustration of the index guide, are shown to increase the threshold for the 1st order mode to prevent it from attaining threshold. The addition these unique mode filters, which do not increase the fabrication complexity, extends the range of single lateral mode operation in narrow stripe devices.
Estimation of field inhomogeneity map following magnitude-based ambiguity-resolved water-fat separation (2023)

Magnitude-based PDFF (Proton Density Fat Fraction) and R<sub>2</sub><sup>∗</sup> mapping with resolved water-fat ambiguity is extended to calculate field inhomogeneity (field map) using the phase images. The estimation is formulated in matrix form, resolving the field map in a least-squares sense. PDFF and R<sub>2</sub><sup>∗</sup> from magnitude fitting may be updated using the estimated field maps. The limits of quantification of our voxel-independent implementation were assessed. Bland-Altman was used to compare PDFF and field maps from our method against a reference complex-based method on 152 UK Biobank subjects (1.5 T Siemens). A separate acquisition (3 T Siemens) presenting field inhomogeneities was also used. The proposed field mapping was accurate beyond double the complex-based limit range. High agreement was obtained between the proposed method and the reference in UK. Robust field mapping was observed at 3 T, for inhomogeneities over 400 Hz including rapid variation across edges. Field mapping following unambiguous magnitude-based water-fat separation was demonstrated in-vivo and showed potential at 3 T.
M-type oscillator with periodic metamaterial-like electrodynamic system (2014)

Metamaterial-like slow wave structure systems are being considered in an O-type and an M-type device. In both systems the period of the structures is much less than the wavelength of the radiation. These devices are being explored for their novel characteristics.
Differential Gene Regulation in Fibroblasts in Co-culture with Keratinocytes and Head and Neck SCC Cells. (2015)

While carcinoma-associated fibroblasts (CAFs) support tumorigenesis, normal tissue fibroblasts suppress tumor progression. Mechanisms behind conversion of fibroblasts into a CAF phenotype are largely unrevealed.Transwell co-cultures with fibroblasts in collagen gels and squamous-cell carcinoma (SCC) cells or normal oral keratinocytes (NOKs) in inserts. Differences in fibroblast global gene expression were analyzed using Affymetrix arrays and subsequent functional annotation and cluster analysis, as well as gene set enrichment analysis were performed.There were 52 up-regulated and 30 down-regulated transcript IDs (>2-fold, p<0.05) in fibroblasts co-cultured with SCC compared to NOKs. Functional analysis demonstrated an enrichment of collagen-related genes. There were similarities with gene sets reflecting a non-specific, innate-type response with activation of both interferon pathways and connective tissue turnover.There were distinct differences in fibroblast gene expression between the co-culture types. Many were in genes related to an innate-type of response and to connective tissue turnover.