gebhart/patrepeval huggingface dataset:
Kindlins in FERM adhesion (2010)

The Kindlin family of intracellular proteins has recently emerged as key regulators of cellular functions and cell-matrix interactions. The 3 members of this family, Kindlin-1, -2, and -3, perform an essential role in activation of integrin adhesion receptors, and expression of at least 1 Kindlin paralog is required to enable integrin activation in physiologically relevant settings. In humans, deficiencies in Kindlin-3 lead to a number of abnormalities affecting hemostasis, the immune system, and bone function, whereas the lack of Kindlin-1 causes profound skin defects. The importance of Kindlins is underscored by the results of animal knockout studies, which clearly show the indispensable and nonredundant functions of all 3 Kindlins in development and normal physiology. This review discusses recent progress in the studies of Kindlin protein family, emphasizing newly identified functions and potential mechanisms underlying differential activities of the family members.
Studies on Simultaneous Enrichment and Detection of Escherichia coli O157:H7 during Sample Shipment (2022)

The USDA-FSIS has zero tolerance for <i>E. coli</i> O157:H7 in raw ground beef. Currently, FSIS collects samples from beef processing facilities and ships them overnight to regional testing laboratories. Pathogen detection requires robust methods that employ an initial 15-24 h culture enrichment. This study assessed the potential of using the ΦV10<i>nluc</i> phage-based luminescence detection assay during enrichment while the sample is in transit. Parameters including phage concentrations, temperature, and media-to-sample ratios were evaluated. Results in liquid media showed that 1.73× 10<sup>3</sup> pfu/mL of ΦV10<i>nluc</i> was able to detect 2 CFU in 10 h. The detection of <i>E. coli</i> O157:H7 was further evaluated in kinetic studies using ratios of 1:3, 1:2, and 1:1 ground beef sample to enrichment media, yielding positive results for as little as 2-3 CFU in 325 g ground beef in about 15 h at 37 °C. These results suggest that this approach is feasible, allowing the detection of a presumptive positive upon arrival of the sample to the testing lab. As the current cargo hold controlled temperature is required to be 15-25 °C, the need for elevated temperature should be easily addressed. If successful, this approach could be expanded to other pathogens and foods.
Modal analysis of TE and TM excitations in a metallic slotted micromirror (2019)

In this work, we present a modal analysis for a metallic slit, where closed-form expressions for the slotted micromirror electric field coupling coefficient and transmittance are derived for both TE and TM polarizations. This can be handy in the design of optical microelectromechanical systems devices and their applications, where the metallic slit is analyzed by solving the eigenfunction problem. The modes excited inside the metallized slotted micromirrors (slit inner structure) are approximated to be the same modes excited inside a parallel plate waveguide structure for TE and TM excitations. The parallel plate waveguide representing the inner walls of the slotted micromirror is assumed to be infinite in the vertical direction. The transmittance of the micromirror with a vertical slit has been calculated for both TE and TM polarizations based on Gaussian beam excitation. Finite-difference time-domain simulation is carried out for the slotted micromirror transmittance, and the results are compared to the modal analysis predictions. A noticeable conformity has been observed.
Splenosis in patient undergoing robotic assisted laparoscopic radical prostatectomy (2022)

Splenosis is a benign condition that is often found in patients with a history of trauma. Most cases are intra-abdominal due to direct seeding of surrounding structures. We report a case of splenosis in the pelvis found in a 59-year-old male during a robotic prostatectomy.
Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis (2021)

Dosage compensation equalizes X-linked expression between XY males and XX females. In male fruit flies, expression levels of the X-chromosome are increased approximately two-fold to compensate for their single X chromosome. In testis, dosage compensation is thought to cease during meiosis; however, the timing and degree of the resulting transcriptional suppression is difficult to separate from global meiotic downregulation of each chromosome. To address this, we analyzed testis single-cell RNA-sequencing (scRNA-seq) data from two Drosophila melanogaster strains. We found evidence that the X chromosome is equally transcriptionally active as autosomes in somatic and pre-meiotic cells, and less transcriptionally active than autosomes in meiotic and post-meiotic cells. In cells experiencing dosage compensation, close proximity to MSL (male-specific lethal) chromatin entry sites (CES) correlates with increased X chromosome transcription. We found low or undetectable levels of germline expression of most msl genes, mle, roX1 and roX2 via scRNA-seq and RNA-FISH, and no evidence of germline nuclear roX1/2 localization. Our results suggest that, although dosage compensation occurs in somatic and pre-meiotic germ cells in Drosophila testis, there might be non-canonical factors involved in the dosage compensation mechanism. The single-cell expression patterns and enrichment statistics of detected genes can be explored interactively in our database: https://zhao.labapps.rockefeller.edu/gene-expr/.
Hyperfine Filtering of an Electro-Optic Modulated Comb (2020)

We present a new architecture for generating low noise electro-optic modulated combs by simultaneously stabilizing and filtering all generated comb lines to a 100,000 finesse etalon. The comb exhibits an instrument limited >60 dB OSNR and ~1.7 ps FWHM pulses.
スター・ウォーズ : ジェダイの試練 (2005)

ジェダイ・ナイトに昇格するチャンスさえ与えられないことに、アナキンはいらだちを募らせていた。そんな彼にとって、プリシトリンでの任務は試金石となるかもしれない。だが、孤立した惑星で援軍を待っていたのは、ハルシオンを目の敵にしているキャプテン・スレイク率いるはぐれ者の軍団。共同戦線をはることもできず、衝突寸前の険悪な空気が漂うなか、ただちに抵抗をやめ撤退しなければ、１時間ごとに人質を殺すという敵の声明が届いた。
Distributed Representation of Geometrically Correlated Images With Compressed Linear Measurements (2012)

This paper addresses the problem of distributed coding of images whose correlation is driven by the motion of objects or the camera positioning. It concentrates on the problem where images are encoded with compressed linear measurements. We propose a geometry-based correlation model that describes the common information in pairs of images. We assume that the constitutive components of natural images can be captured by visual features that undergo local transformations (e.g., translation) in different images. We first identify prominent visual features by computing a sparse approximation of a reference image with a dictionary of geometric basis functions. We then pose a regularized optimization problem in order to estimate the corresponding features in correlated images that are given by quantized linear measurements. The correlation model is thus given by the relative geometric transformations between corresponding features. We then propose an efficient joint decoding algorithm that reconstructs the compressed images such that they are consistent with both the quantized measurements and the correlation model. Experimental results show that the proposed algorithm effectively estimates the correlation between images in multiview data sets. In addition, the proposed algorithm provides effective decoding performance that advantageously compares to independent coding solutions and state-of-the-art distributed coding schemes based on disparity learning.
Role of nitrogen ions in ion‐beam reactive sputtering of NbN (1990)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. J. Lichtenwalner, Alfredo C. Anderson, D. A. Rudman; Role of nitrogen ions in ion‐beam reactive sputtering of NbN. Journal of Vacuum Science & Technology A 1 May 1990; 8 (3): 1283–1287. https://doi.org/10.1116/1.576912 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Cure rate in the elderly patients with diffuse large B cell lymphoma deteriorates after the age of 80—results from a single-center survey (2021)

The prognosis of elderly patients diagnosed with diffuse large B cell lymphoma (DLBCL) is considered to be clearly inferior to that of younger patients. Besides tumor biology and comorbidities, treatment selection due to an assumed reduced tolerability may contribute to this difference. With increasingly more patients diagnosed at advanced age, current treatment selections need to be reviewed carefully. Hence, we analyzed the results of patients above the age of 70 in whom a diagnosis of DLBCL was made. Whereas patients up to 80 were frequently selected for and were able to tolerate standard treatment (86% intended use, 74% completion), patients above the age of 80 years were not only treated more cautiously (67 and 60%, respectively) but did show inferior response to treatment with standard treatment (CR rate for intended R-CHOP use 64% vs. 43%). However, on an individual level, patients receiving and completing standard treatment obtained results that resemble the results of younger patients, irrespective if aged more than 80 and impose superior to prior reports in this age cohort. Median PFS for the entire group of patients was 3.44 years, with 4.83 years for patients below 80 and only 1.09 years for patients above the age of 80. The corresponding figures for OS were 7.38 years (estimated); after 2 years, OS was 81% in the younger cohort in contrast to 68% in patients > 80 years. However, for patients not planned to receive or not tolerating R-CHOP, results remain poor; tailored approaches for these patients are required.
ChemInform Abstract: Facile Syntheses of Building Blocks for the Construction of Phosphotyrosine Mimetics. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
APX001A Protects Immunosuppressed Mice from Rhizopus delemar Infection (2017)

Mucormycosis is a life-threatening infection with high mortality that occurs predominantly in immunocompromised patients. APX001A is an antifungal agent that targets Gwt1, an early step in the conserved glycosylphosphotidyl inositol (GPI) post-translational modification pathway of surface proteins in eukaryotic cells. Inhibition of inositol acylation by APX001A results in pleiotropic effects such as inhibition of maturation of GPI-anchored proteins necessary for growth and virulence and results in lethality. APX001A has in vitro activity against Mucorales. Here we assessed the in vivo activity of APX001A against Rhizopus delemar (MIC = 0.25 µg/mL). ICR mice were immunosuppressed with cyclophosphamide (200 mg/kg) and cortisone acetate (500 mg/kg) on days -2, +3, and +8 relative to intratracheal infection with 2.5 x 105 cells of R. delemar 99–880. For survival studies, treatment with APX001 (prodrug) at 52, 104, or 156 mg/kg (twice daily, po), was compared with liposomal amphotericin B (LAmB) at 15 mg/kg (once daily, iv). Treatment started on day +1 through day +8 for APX001 and through day +4 for LAmB. Placebo mice received vehicle control. For fungal burden studies, dosing started 8 hours post infection through day +3. Mice were sacrificed on day +4. Survival time, and tissue fungal burden (by qPCR) served as efficacy endpoints. APX001 treatment at either 52 or 104 mg/kg prolonged survival of mice vs. placebo (n = 20 per arm) (21-day survival of 0% for placebo, 30% for 52 mg/kg, 45% for 104 mg/kg, P < 0.05 by Log Rank test). APX001 at 104 mg/kg was as good as LAmB treatment (21-day survival of LAmB-treated mice [n = 20] =50%). APX001 at 156 mg/kg did not enhance survival vs. placebo. Further, APX001 at 104 mg/kg and LAmB reduced pulmonary and brain fungal burden by ~1 log and 1.5 log vs. placebo, respectively (P < 0.05, by Wilcoxon rank-sum). The 52 and the 156 mg/kg APX001 doses also reduced tissue fungal burden vs. placebo mice (0.5–1.0 log). APX001 protected immunosuppressed mice from R. delemar infection with efficacy similar to that of LAmB. Higher doses of APX001 were not protective despite lowering fungal burden. Continued investigation of APX001 as a novel antifungal agent against mucormycosis is warranted. K. J. Shaw, Amplyx Pharmaceuticals Inc.: Employee, Salary; Linnaeus: Consultant, Consulting fee
Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells (2014)

ACE2 protein was proposed as a receptor for HCoV-NL63 already in 2005, but an in-depth analysis of early events during virus infection had not been performed thus far. Here, we show that the ACE2 protein is required for viral entry but that it is not the primary binding site on the cell surface. Conducted research showed that heparan sulfate proteoglycans function as adhesion molecules, increasing the virus density on cell surface and possibly facilitating the interaction between HCoV-NL63 and its receptor. Obtained results show that the initial events during HCoV-NL63 infection are more complex than anticipated and that a newly described interaction may be essential for understanding the infection process and, possibly, also assist in drug design.
Modeling the response of small myelinated and unmyelinated axons to kilohertz frequency signals (2015)

The effects of kilohertz frequency signals on action potential conduction in small myelinated (1 to 5.7 μm diameter) and unmyelinated axons are poorly understood, but could have important therapeutic applications. We developed a finite element model of a compound peripheral nerve and quantified the effects of a 5 kHz signal delivered via cuff electrode on conduction in small myelinated and unmyelinated axons. We compared the results from this realistic model to responses to the same signal delivered by an extracellular point source in a homogeneous isotropic extracellular medium. Using typical clinical parameters, the primary effect of the 5 kHz signal was excitation of the 5.7 μm diameter myelinated fibers in both models. The unmyelinated fibers were mostly unaffected by the applied signal. Axonal conduction block occurred only for certain parameter sets in the 5.7 μm diameter myelinated fibers. Our model reveals the complexity of possible responses to kilohertz frequency signals, and suggests that mechanisms of therapeutic efficacy other than conduction block need to be considered. A better understanding of the effects of kilohertz frequency signals is needed to inform clinical parameter selection for electrical devices targeting conduction block in small fibers.
N-Terminal Pro-B-Type Natriuretic Peptide and Prognosis in Caucasian vs. Asian Patients with Heart Failure (2018)

NT-proBNP has similar prognostic performance in Asians and Caucasians with HF despite ethnic differences in known clinical determinants of plasma NT-proBNP.
Datagram Transport Layer Security (DTLS) as Transport for Traversal Using Relays around NAT (TURN) (2014)

This document specifies the usage of Datagram Transport Layer Security
(DTLS) [RFC6347] as a transport protocol between a Traversal Using
Relays around NAT (TURN) [RFC5766] client and a TURN server. It also
specifies modifications to the TURN URIs [RFC7065] and to the TURN
resolution mechanism [RFC5928] to facilitate the resolution of TURN
URIs into the IP address and port of TURN servers supporting DTLS as a
transport protocol.
Frictional behaviour of polymer films under mechanical and electrostatic loads (2013)

Different polymer foils, namely polyimide, FEP, PFA and PVDF were tested on a setup designed to measure the static coefficient of friction between them. The setup was designed according to the requirements of a damping device based on electrostatically tunable friction. The foils were tested under different mechanically applied forces and showed reproducible results for the static coefficient of friction. With the same setup the measurements were performed under an electric field as the source of the normal force. Up to a certain electric field the values were in good agreement. Beyond this field discrepancies were found.
Improved Detection of Subendocardial Hyperenhancement in Myocardial Infarction Using Dark Blood–Pool Delayed Enhancement MRI (2011)

Dark blood-pool delayed enhancement is complementary to the reference standard. It can detect more subendocardial foci of hyperenhancement, thus potentially identifying more infarcts and changing patient management.
Field experiments of medium-wave broadcasting antenna on mountain top. (1987)

中波放送アンテナは従来, 都市郊外の導電率の高い平面大地に設置されてきたが, 用地難や電磁環境問題などが生じているそこで, アンテナ設置場所に山岳を利用することが考えられる800MHz帯を用いた小型モデル実験によると, 山頂アンテナの方が平面大地上のアンテナに比べて動作利得が高くなる場合のあることが指摘されているこのことを確認するために, 放送波により近い周波数を使った野外ての大型モテル実験を行った本論文ではこの実験の結果について述べているこの実験では, 周波数帯は10～50MHzであり, 山岳モテルの高さは375mとし, その上に埋設接地線を施したモノポールアンテナを直立させたこの実験装置を用いて入力インピーダンスと電界強度の測定を行い, 平面大地上アンテナの測定結果と比較を行ったその結果, 山の高さ1/4波長およひ1/2波長, アンテナ高1/4波長に対して, 平面上アンテナよりも山頂アンテナの方が利得が高くなることが定量的に確認され, ほかのパラメータにおいても山頂アンテナの方が高い動作利得を示したこれらのことから, 中波放送アンテナを山頂に設置することが実用上有効であるとの結論を得た
ChemInform Abstract: Conformational Properties of the THYME Polyethers. The Bis‐THYME Cylinder: A Three‐Dimensional Analogue of 18‐Crown‐6. (1988)

Abstract The title compound (II) is characterized by molecular mechanics calculations and as the free ligand, as the toluene solvate, and as a novel cascade complex (K 2 (OH 2 )·(III))2+(PtCl3·DMSO) 2 2‐ by means of crystal structures (space group of (II)·toluene: P1, Z=1 and P2 1 /c, Z=2 for the other two cases).
Application-specific architectural methodologies for high-throughput digital signal and image processing (1990)

An attempt has been made to classify the architectural styles suited for application-specific high-throughput DSP (digital signal processing) applications. In principle, they can be classified between the two extremes of cooperating multiplexed data paths and regular arrays which adopt hard-wired control flow with low hardware sharing. Three DSP subclasses have been identified according to the required sample rate in combination with the regularity and modularity of the flowgraph and the types of operation which are involved, such as straightforward arithmetic or complex decision making with loops and branches. Correspondingly, three architectural strategies have been identified as efficient candidates for realization, namely, microcoded multiprocessors, cooperating multiplexed data paths, and regular arrays. Architectures exploiting large hardware-sharing ratio's which are more suited for the back-end modules in the target DSP system are investigated. Realistic test vehicles are discussed in order to evaluate the alternatives. Moreover, guidelines have been extracted to select such an ASIC (application-specific integrated circuit) architecture. These are dependent on the required throughput, the structure of the algorithm, and the corresponding signal flowgraph.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Kinetics of Formation of Propylenediaminetetraacetatocobaltate(III) from the Corresponding Pentadentate Complexes (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Formation of Propylenediaminetetraacetatocobaltate(III) from the Corresponding Pentadentate ComplexesK. Swaminathan and Daryle H. BuschCite this: Inorg. Chem. 1962, 1, 2, 256–260Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/ic50002a012https://doi.org/10.1021/ic50002a012research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Victim macro UE detection procedure based on network assistance in LTE-femtocell networks (2012)

In long term evolution (LTE), home evolved node B (HeNB) has been introduced to improve indoor channel quality and take over indoor traffic from macro eNB (MeNB) at a low cost. As MeNB and HeNB share radio resources to obtain high capacity, victim macro user equipments (VMUEs) may exist due to severe interference from HeNB. For efficiently coordinating interference to the VMUEs, the HeNB should exactly perceive presence and absence of its neighboring VMUEs. In this paper, we propose a VMUE detection procedure based on network assistance in LTE-femtocell networks. By using the proposed detection procedure, HeNB can appropriately perform interference coordination (IC) as detection results of VMUE. Performance evaluations show the throughput of MUEs can be improved by combining the proposed procedure and IC.
Resonant Excitation of a Quantum Dot Strongly Coupled to a Photonic Crystal Nanocavity (2010)

We describe the resonant excitation of a single quantum dot that is strongly coupled to a photonic crystal nanocavity. The cavity represents a spectral window for resonantly probing the optical transitions of the quantum dot. We observe narrow absorption lines attributed to the single and biexcition quantum dot transitions and measure antibunched population of the detuned cavity mode [g{(2)}(0)=0.19].
Structure‐Activity relations of LHRH in birds (1984)

Structural requirements in LHRH for gonadotropin-releasing activity were investigated by comparing the activity of the natural vertebrate LHRH structural variants and synthetic analogues. Substitution of Arg8 results in a loss of activity of LHRH in mammals, whilst a number of amino acid substitutions for Arg8 retain high gonadotropin-releasing activity in the chicken. Thus Arg8 of LHRH comprises an integral part of the binding site of LHRH and/or contributes towards the conformation of the binding site for the mammalian receptor while this does not pertain in the bird. The possibility that relative conformational stabilization of LHRH is important for biological activity in mammals but not birds, was supported by the demonstration that a gamma-lactam conformationally constrained analogue of LHRH was more active than LHRH in the mammalian system but equipotent in the bird. The chicken LHRH receptor is also relatively undiscriminating with regard to amino acid substitutions in positions 5 and 7. A series of LHRH analogues with pure antagonist activity in rats exhibited a spectrum of activities, from pure agonist to mixed activity and pure antagonist, in the chicken. These differences in LHRH structural requirements of the mammalian and avian receptor are reflected by a difference in molecular size of the chicken receptor (67,000) and mammalian receptor (60,000). Nevertheless, like the mammalian pituitary, the chicken pituitary does exhibit "desensitization" on prolonged exposure to LHRH.