gebhart/patrepeval huggingface dataset:
Uplink Interference Control in UTRAN LTE Based on the Overload Indicator (2008)

3GPP has recently agreed on an Open Loop Power Control (OLPC) for the uplink in UTRAN Long Term Evolution. The power control configuration determines the level of interference in the system, but requires to be tuned depending on the propagation scenario, user's bandwidth, etc. A reliable knowledge of the interference would be very useful for the operator to determine the maximum link budget for a certain coverage performance. In this paper we propose a novel algorithm to use the Overload Indicator for an automatic adjustment of the OLPC parameters to achieve the desired interference operating point, showing its potential compared to an a priori setting.
EFFECTS OF ADRENALECTOMY ON REPRODUCTION IN THE MOUSE (1980)

Survival of mice treated with sesame seed oil after adrenalectomy was very low and suggested no beneficial effect, whereas treatment with progesterone improved the chances of survival. Treatment with desoxycorticosterone acetate (DOCA) and methyl prednisolone acetate also increased the number of animals surviving after adrenalectomy. The corticosteroids were significantly more effective in ensuring survival than was progesterone. There was no significant difference in survival between mice receiving a single injection of 1.0 mg DOCA and those being given an injection of 1.0 mg DOCA per day for 3 days after the operation. To ensure minimum interference of exogenous corticosteroid with the experimental investigation, animals routinely received only a single injection of 1.0 mg DOCA after the operation. The chance of survival after adrenalectomy was higher in pregnant than in non-pregnant mice. There was a significant linear increase in survival during the first 5 days of pregnancy. Progesterone and prolactin both appeared to be involved in increasing the chance of survival in adrenalectomized pregnant mice. Adrenalectomy had no effect on the number of mice mating and ovulating. Adrenalectomized mice were apparently having normal cycles and 4 weeks after adrenalectomy they were able to mate and ovulate. Compensatory ovulation was seen in hemi-ovariectomized mice and was not abolished by adrenalectomy. Implantation was also unaffected by the operation.
Mutations and Pituitary Adenomas: An International Collaborative Study AIP Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line (2010)

J. Clin. Endocrinol. Metab. 2010 95:E373-E383 originally published online Aug 4, 2010; , doi: 10.1210/jc.2009-2556 €Lauri A. Aaltonen and Albert Beckers Gunter K. Stalla, Anna Spada, Sabina Zacharieva, Jerome Bertherat, Thierry Brue, Vincent Bours, Philippe Chanson, Anne-Paule Gimenez-Roqueplo, Fergus J. Cameron, Francoise Borson-Chazot, Ian Holdaway, Sergio P. A. Toledo,Halaby, Vinciane Corman, Marie-Therese Hagelstein, Jean-Francois Vanbellinghen, Gustavo Barcelos Barra, Saloranta, Wouter De Herder, Renato Cozzi, Mirtha Guitelman, Flavia Magri, Maria Stefania Lagonigro, GeorgesLongas, Jose Ignacio Labarta Aizpun, Marianthi Georgitsi, Ralf Paschke, Cristina Ronchi, Matti Valimaki, Carola A. Toledo, Maria Isabel Sabate, Chiara Villa, Marc Popelier, Roberto Salvatori, Juliet Jennings, Angel FerrandezAntoine Tabarin, Elisa Verrua, Eija Eloranta, Arnaud Murat, Outi Vierimaa, Pasi I. Salmela, Philippe Emy, Rodrigo Montanana, Gerald Raverot, Robert J. Weil, Timo Sane, Dominique Maiter, Sebastian Neggers, Maria Yaneva,Luciana A. Naves, Tapani Ebeling, Auli Karhu, Antti Raappana, Laure Cazabat, Ernesto De Menis, Carmen Fajardo Adrian F. Daly, Maria A. Tichomirowa, Patrick Petrossians, Elina Heliovaara, Marie-Lise Jaffrain-Rea, Anne Barlier,
Novel Block Copolymers with Terpyridine Pendant Groups (2006)

Polymer architectures containing metal-ligands in their side chain represent a diverse and highly functional approach to hybrid organic-inorganic materials. The ability to synthesize block copolymers has recently been demonstrated and is facilitated by advances in controlled radical polymerization techniques. Using a combination of the three most common methods, a variety of block copolymers have been prepared. Both a direct and indirect approach to ligand incorporation was demonstrated. Subsequent functionalization with metal ions leads to a cornucopia of properties illustrated here by metal induced gelation and solvochromic sensors.
Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling (1999)

Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the importance of phosphatidylinositol-3' kinase (PI3K) signaling in these responses by mutating the PI3K-binding sites in the PDGF-beta receptor by gene targeting in embryonic stem cells. Homozygous mutant mice developed normally; however, cells derived from the mutants were less chemotactic and had largely lost their ability to contract collagen gels in response to PDGF. Injection of a mast cell degranulating agent in mice led to a decrease in interstitial fluid pressure resulting in edema formation. In contrast to wild-type mice, mutant mice were unable to normalize the pressure after treatment with PDGF. Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures.
ChemInform Abstract: Catalytic Enantioselective Alkylation of Alkenes by Chiral Metallocenes (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The 2006–2010 Strategic Plan for the Poultry Science Association (2006)

The Poultry Science Association (PSA) leadership has created its first comprehensive 5-year strategic plan (2006 to 2010) as a guide to the organization's growth and development. As societal concerns about animal agriculture increase and as changes in the poultry industry and in universities reduce the numbers of poultry scientists and thus membership in PSA, it became apparent that, to maintain relevance, the PSA needed to undertake a more rigorous and comprehensive review of its assets, areas of weakness, and reasons for being. The strategic planning process provided the lens for organizational analysis and planning. Our new mission for the PSA is to be a global scientific society dedicated to discovery and dissemination of knowledge, generated by poultry research that enhances human and animal health and well-being and provides for the ethical, sustainable production of food. The Association's vision is to be a preeminent global organization of poultry scientists and industry leaders, firmly grounded in scientific endeavors related to the biology and production of poultry. Increased membership diversity will be pursued by recruiting people of varied geographic, gender, cultural, and scientific backgrounds—including health and medicine—leading to a diverse leadership. The PSA will serve as the clearinghouse for poultry science information and provide through its Foundation significant financial support to students and young scientists engaged in poultry science research, teaching, and outreach education. The PSA, in partnership with the Federation of Animal Science Societies (FASS), will be a highly credible, well-respected, powerful force that is able to influence policy makers at governmental levels for the benefit of animal agriculture by delivering sound scientific information. The strategic plan highlights strategic directions to be implemented as well as assessment of progress. It will take the vision, energy, and dedication of PSA leaders and members to ensure that the strategic plan is well implemented, monitored, and altered appropriately, keeping it a living plan of action.
A Novel Achiral seco-Amino-Cyclopropylindoline (CI) Analog of CC-1065 and the Duocarmycins: Design, Synthesis and Biological Studies (2005)

The design, synthesis and DNA binding properties of a novel achiral and amino-containing seco-cyclopropylindoline analog (seco-amino-CI-TMI, 1) of the duocarmycins are described. Thermal induced DNA cleavage studies on pUC18 DNA revealed compound 1 to preferentially bind in the minor groove and to covalently react with AT-rich sequences, particularly at the underlined adenine-N3 group of 5'-AAAAA(865)-3'. This sequence specificity is similar to adozelesin and CC-1065. Using a 4-day continuous exposure, compound 1 inhibited the growth of K562 human chronic myeloid leukemia cells in culture. Compound 1 has appreciable cytotoxicity (IC50 value of 1.30 microM) relative to compound 2 (0.15 microM), the corresponding racemic and hydroxy-seco-CI-TMI analog. These results indicate that the aminophenethyl chloride group present in compound 1 has similar sequence specific and cytotoxic properties to the hydroxy-containing seco-precursors of CC-1065 and the duocarmycins. Moreover, the results suggest that the chiral center present in the natural products is not absolutely necessary for biological activity. The novel aminophenethyl halide moiety is, therefore, a useful template from which to develop future achiral analogs of CC-1065 and the duocarmycins.
Long-alkyl-chain-derivatized imidazolium salts and ionic liquid crystals with tailor-made properties (2014)

New ionic liquids and ionic liquid crystalline materials with custom-tailored properties were synthesized based on long-alkyl-chain-derivatized 1,3-dialkylimidazolium salts.
Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative. (1992)

The NF-kappa B transcription factor complex is composed of two proteins, designated p50 and p65, both having considerable homology to the product of the rel oncogene. We present evidence that the p65 subunit is a potent transcriptional activator in the apparent absence of the p50 subunit, consistent with in vitro results demonstrating that p65 can interact with DNA on its own. To identify the minimal activation domain, chimeric fusion proteins between the DNA binding domain of the yeast transcriptional activator protein GAL4 and regions of the carboxy terminus of p65 were constructed, and their transcriptional activity was assessed by using a GAL4 upstream activation sequence-driven promoter-chloramphenicol acetyltransferase fusion. This analysis suggests that the boundaries of the activation domain lie between amino acids 415 and 550. Moreover, single amino acid changes within residues 435 to 459 greatly diminished activation. Similar to other activation domains, this region contains a leucine zipper-like motif as well as an overall net negative charge. To identify those residues essential for DNA binding, we made use of a naturally occurring derivative of p65, lacking residues 222 to 231 (hereafter referred to as p65 delta), and produced via an alternative splice site. Gel mobility shift analysis using bacterially expressed p65, p65 delta, and various mutants indicates that residues 222 to 231 are important for binding to kappa B DNA. Coimmunoprecipitation analysis suggests that these residues likely contribute to the multimerization function required for homomeric complex formation or heteromeric complex formation with p50 in that no association of p65 delta with itself or with p50 was evident. However, p65 delta was able to form weak heteromeric complexes with p65 that were greatly reduced in their ability to bind DNA. On the basis of these findings, we suggest that subtle changes within the proposed multimerization domain can elicit different effects with the individual Rel-related proteins and that a potential role of p65 delta may be to negatively regulate NF-kappa B function through formation of nonfunctional heteromeric complexes.
Effects of Type I Interferons on the Adjuvant Properties of Plasmid Granulocyte-Macrophage Colony-Stimulating Factor In Vivo (2007)

While administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce the local recruitment of activated antigen-presenting cells at the site of vaccine inoculation, this cellular recruitment is associated with a paradoxical decrease in local vaccine antigen expression and vaccine-elicited CD8+ T-cell responses. To clarify why this cytokine administration does not potentiate immunization, we examined the recruited cells and expressed inflammatory mediators in muscles following intramuscular administration of plasmid GM-CSF in mice. While large numbers of dendritic cells and macrophages were attracted to the site of plasmid GM-CSF inoculation, high concentrations of type I interferons were also detected in the muscles. As type I interferons have been reported to damp foreign gene expression in vivo, we examined the possibility that these local innate mediators might decrease plasmid DNA expression and therefore the immunogenicity of plasmid DNA vaccines. In fact, we found that coadministration of an anti-beta interferon monoclonal antibody with the plasmid DNA immunogen and plasmid GM-CSF restored both the local antigen expression and the CD8+ T-cell immunogenicity of the vaccine. These data demonstrate that local innate immune responses can change the ability of vaccines to generate robust adaptive immunity.
Fabrication of high-resolution micropolarizer arrays (1997)

Procedures for creating high-resolution polarization filter ar- rays using multilayer polyvinyl alcohol (PVA) films are described. Two state polarization filter arrays with 25mm resolution and three state po- larization filter arrays with 48 mm resolution are demonstrated. © 1997 Society of Photo-Optical Instrumentation Engineers. (S0091-3286(97)01608-5)
Neuromorphic computing with integrated photonics and superconductors (2016)

We present a hardware platform combining integrated photonics with superconducting electronics for large-scale neuromorphic computing. Semiconducting few-photon light-emitting diodes work in conjunction with superconducting-nanowire single-photon detectors to behave as spiking neurons. These neurons are connected through a network of waveguides, and variable weights of connection can be implemented using several approaches. These processing units can operate at 20 MHz with fully asynchronous activity, light-speed-limited latency, and power densities on the order of 1 mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The processing units achieve an energy efficiency of 20 aJ/synapse event, an improvement of six orders of magnitude over recent CMOS demonstrations [1]. We present calculations showing this approach could scale to interconnectivity near that of the human brain, and could surpass the brain in speed and efficiency.
Subcortical Atrophy in Cognitive Impairment and Dementia (2015)

Subcortical gray matter atrophy is not only observed in dementia, but also in the preclinical stages of cognitive impairment. Furthermore, besides VCI, subcortical structures were also related to non-VCI.
Three-Dimensional Microscopy: Image Processing For High Resolution Subcellular Imaging (1989)

Recent technological advances now make it practical to record three-dimensional data from biological specimens using fluorescence light microscopy. When three-dimensional images are collected using a conventional microscope, each observed section contains in-focus information from the parts of the sample at the focal plane and out-of-focus information from the remainder of the sample. The imaging process can be characterized as a convolution of the sample with the point spread function (PSF) of the microscope. We have experimentally determined the PSF for an epifluorescence microscope using high numerical aperture oil and water immersion lenses. Several methods for the processing of the observed data are discussed, with the best results obtained by constrainediterative deconvolution methods.
Slow clearance gadolinium‐based extracellular and intravascular contrast media for three‐dimensional MR angiography (2001)

The objective of this study was to assess two new slow-clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd-DTPA-BC(2)glucA and intravascular Gd(DO3A)(3)-lys(16) were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD-A2-Gd-DOTA and extracellular GdDOTA, in 12 rats. Pre- and post-contrast three-dimensional MR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm(3)) was acquired for 2 hours. Signal-to-noise enhancement (DeltaSNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The DeltaSNR for Gd-DTPA-BC(2)glucA, Gd(DO3A)(3)-lys(16), CMD-A2-Gd-DOTA, and GdDOTA were 13.0 +/- 1.8, 25.0 +/- 3.2, 25.0 +/- 4.0, and 18.0 +/- 3.4, respectively. Gd-DTPA-BC(2)glucA, Gd(DO3A)(3)-lys(16), and CMD-A2-Gd-DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular DeltaSNR at 2 hours were 2.9 +/- 0.6, 25.0 +/- 3.2, 25.0 +/- 4.0, and 0.4 +/- 1.0. Gd(DO3A)(3)-lys(16) provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd-DTPA-BC(2)glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability.
Hydrogen Behavior in Top Gate Amorphous In–Ga–Zn–O Device Fabrication Process During Gate Insulator Deposition and Gate Insulator Etching (2021)

The hydrogen behavior in the amorphous In-Ga-Zn-O (a-IGZO) thin-film layer according to the device process with top gate structure was quantitatively investigated. The hydrogen quantities in the a-IGZO thin-film layer with gate insulator (w/GI) and after GI dry-etching were increased by 3.40×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sup> and 2.50×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , respectively, in comparison with without GI (w/o GI). In addition, the calculated carrier concentration of the a-IGZO thin-film layer by band alignment increased by 1.60×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> and 7.38×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , respectively, compared with w/o GI. Due to the plasma effect, the hydrogen quantity and the calculated carrier concentration in the a-IGZO thin-film layer after GI dry-etching slightly decreased from w/GI by 0.90 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sup> and 8.62 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , respectively. The increased hydrogen quantity in the a-IGZO thin-film layer can contribute to increase in carrier concentration by providing free electrons through the hydrogen reaction with oxygen ions or transition of hydrogen state. Here, we attempted to correlate the hydrogen effect to the increase of the carrier concentration through various physical analysis.
Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody (2021)

Antibody-based immunotherapy is a promising strategy for targeting chemoresistant leukemic cells. However, classical antibody-based approaches are restricted to targeting lineage-specific cell surface antigens. By targeting intracellular antigens, a large number of other leukemia-associated targets would become accessible. In this study, we evaluated a novel T-cell bispecific (TCB) antibody, generated by using CrossMAb and knob-into-holes technology, containing a bivalent T-cell receptor-like binding domain that recognizes the RMFPNAPYL peptide derived from the intracellular tumor antigen Wilms tumor protein (WT1) in the context of HLA-A*02. Binding to CD3ε recruits T cells irrespective of their T-cell receptor specificity. WT1-TCB elicited antibody-mediated T-cell cytotoxicity against AML cell lines in a WT1- and HLA-restricted manner. Specific lysis of primary acute myeloid leukemia (AML) cells was mediated in ex vivo long-term cocultures by using allogeneic (mean ± standard error of the mean [SEM] specific lysis, 67 ± 6% after 13-14 days; n = 18) or autologous, patient-derived T cells (mean ± SEM specific lysis, 54 ± 12% after 11-14 days; n = 8). WT1-TCB-treated T cells exhibited higher cytotoxicity against primary AML cells than an HLA-A*02 RMF-specific T-cell clone. Combining WT1-TCB with the immunomodulatory drug lenalidomide further enhanced antibody-mediated T-cell cytotoxicity against primary AML cells (mean ± SEM specific lysis on days 3-4, 45.4 ± 9.0% vs 70.8 ± 8.3%; P = .015; n = 9-10). In vivo, WT1-TCB-treated humanized mice bearing SKM-1 tumors exhibited a significant and dose-dependent reduction in tumor growth. In summary, we show that WT1-TCB facilitates potent in vitro, ex vivo, and in vivo killing of AML cell lines and primary AML cells; these results led to the initiation of a phase 1 trial in patients with relapsed/refractory AML (#NCT04580121).
Cancer mortality trends between 1988 and 2009 in the metropolitan area of Naples and Caserta, Southern Italy (2013)

Mortality data by geographic area and trend-based surveillance are particularly relevant in orienting public health decisions targeting specific populations. We analyzed overall and site-specific cancer mortality between 1988 and 2009 in the metropolitan area of Naples and Caserta in southern Italy. Age-standardized mortality rates (SMR) were computed for each 5-y age group, by gender, primitive cancer site and specific Province in the overall population and age-defined subgroups. Cancer mortality trends were quantified by annual percent change (APC) and 95% confidence interval (CI). From Naples and Caserta, the reduction observed between 1988 and 2009 in SMR in males, but not in females, was significantly lower compared with the decrease reported at a national level (-11.4% and -28.4%, respectively). In elderly men, differences between local and national SMR were more pronounced (+13.6% compared with -2.7%). In males, the joinpoint regression analysis showed the following APC and 95% CI: -0.9%/year (-1.2; -0.7) and -0.6%/year (-1.0; -0.2) for Naples and Caserta, respectively. In females, estimates were -0.6%/year (-0.8; -0.5) and -0.7%/year (-1.2; -0.3). The overall orientation toward declining cancer mortality trends appeared in antithesis with the slight, but significant, increase for some tumors (e.g., pancreatic cancer in both genders). A complex mixture of heterogeneous factors concurs to explain the evidence observed including lifestyle, access to screening procedures, advancements in cancer diagnosis and treatment. Further details might eventually derive from biomonitoring studies for ascertaining the causal link between exposure to potential contaminants in air, water, and soil and cancer-related outcomes in the area of interest.
Proceedings of the IEEE International Conference on Cloud and Autonomic Computing (ICCAC), 2015 (2015)

International audience