gebhart/patrepeval huggingface dataset:
Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats (2005)

We investigated the effect of subdiaphragmatic vagal deafferentation (SDA) on food intake, body weight gain, and metabolism in obese (fa/fa) and lean (Fa/?) Zucker rats. Before and after recovery from surgery, food intake and body weight gain were recorded, and plasma glucose and insulin were measured in tail-prick blood samples. After implantation of a jugular vein catheter, an intravenous glucose tolerance test (IVGTT) was performed, followed by minimal modeling to estimate the insulin sensitivity index. Food intake relative to metabolic body weight (g/kg(0.75)) and daily body weight gain after surgery were lower (P < 0.05) in SDA than in sham obese but not lean rats. Before surgery, plasma glucose and insulin concentrations were lower (P < 0.05) in lean than in obese rats but did not differ between surgical groups within both genotypes. Four weeks after surgery, plasma glucose and insulin were still similar in SDA and sham lean rats but lower (P < 0.05) in SDA than in sham obese rats. IVGTT revealed a downward shift of the plasma insulin profile by SDA in obese but not lean rats, whereas the plasma glucose profile was unaffected. SDA decreased (P < 0.05) area under the curve for insulin but not glucose in obese rats. The insulin sensitivity index was higher in lean than in obese rats but was not affected by SDA in both genotypes. These results suggest that elimination of vagal afferent signals from the upper gut reduces food intake and body weight gain without affecting the insulin sensitivity index measured by minimal modeling in obese Zucker rats.
Feature Engineering for Predictive Modeling Using Reinforcement Learning (2018)

Feature engineering is a crucial step in the process of predictive modeling. It involves the transformation of given feature space, typically using mathematical functions, with the objective of reducing the modeling error for a given target. However, there is no well-defined basis for performing effective feature engineering. It involves domain knowledge, intuition, and most of all, a lengthy process of trial and error. The human attention involved in overseeing this process significantly influences the cost of model generation. We present a new framework to automate feature engineering. It is based on performance driven exploration of a transformation graph, which systematically and compactly captures the space of given options. A highly efficient exploration strategy is derived through reinforcement learning on past examples.
A 30-km-long optical fiber link for frequency comparison between distant strontium optical lattice clocks (2013)

We demonstrate a 30-km-long optical fiber link for frequency comparison between two strontium optical lattice clocks being developed at Riken and the University of Tokyo. We use a transfer laser at 1397 nm which is twice the wavelength of the clock transition of strontium clocks. The link stability is estimated to be 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> for an averaging time τ = 1 s, which is in good agreement with the theoretical limit calculated from the fiber noise spectrum. We discuss a remote clock comparison with stability of 10 (τ/s) by synchronously operating the two distant clocks.
Amphiphilic Diblock Copolymer Compatibilizers and Their Effect on the Morphology and Performance of Polythiophene:Fullerene Solar Cells (2005)

A diblock copolymer containing a fullerene(C60)-rich block and a poly(3-hexylthiophene) block functions as a compatibilizer in poly(3-hexylthiophene):[6,6]-phenyl C61-butyric acid methyl ester (P3HT:PCBM) blends. The copolymer is used to probe the impact of morphology and phase-segregation kinetics on the performance of P3HT:PCBM-based solar cells. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c1787_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Rate Dependent Multi-Mechanism Discharge of Ag0.50VOPO4·1.8H2O: Insights from In Situ Energy Dispersive X-ray Diffraction (2016)

Ag<sub>0.50</sub>VOPO<sub>4</sub>·1.8H<sub>2</sub>O (silver vanadium phosphate, SVOP) demonstrates a counterintuitive higher initial loaded voltage under higher discharge current. Energy dispersive X-ray diffraction (EDXRD) from synchrotron radiation was used to create tomographic profiles of cathodes at various depths of discharge for two discharge rates. SVOP displays two reduction mechanisms, reduction of a vanadium center accompanied by lithiation of the structure, or reduction-displacement of a silver cation to form silver metal. In-situ EDXRD provides the opportunity to observe spatially resolved changes to the parent SVOP crystal and formation of Ag<sup>0</sup> during reduction. At a C/170 discharge rate V<sup>5+</sup> reduction is the preferred initial reaction resulting in higher initial loaded voltage. At a discharge rate of C/400 reduction of Ag<sup>+</sup> with formation of conductive Ag<sup>0</sup> occurs earlier during discharge. Discharge rate also affects the spatial location of reduction products. The faster discharge rate initiates reduction close to the current collector with non-uniform distribution of silver metal resulting in isolated cathode areas. The slower rate develops a more homogenous distribution of reduced SVOP and silver metal. This study illuminates the roles of electronic and ionic conductivity limitations within a cathode at the mesoscale and how they impact the course of reduction processes and loaded voltage.
Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells (2020)

Taken together, our data unravel a new role for TSP-1/CD47 signaling in mediating Ca<sup>2+</sup> influx into RBCs, a mechanism potentially contributing to their dysfunction in a variety of systemic diseases. Video abstract.
Disaccharides generated from heparan sulphate or heparin modulate chemokine‐induced T‐cell adhesion to extracellular matrix (2000)

We have found previously that disaccharides (DS) enzymatically generated from heparin or heparan sulphate can modulate tumour necrosis factor-alpha (TNF-alpha) secretion from immune cells in vitro and cell-mediated immune reactions in vivo. Here, we show that such DS can modulate the adhesion and migration of human T cells. We found that certain heparin- and heparan sulphate-derived DS induced, in a dose-dependent manner, the adhesion of human T cells to both extracellular matrix (ECM) and immobilized fibronectin (FN); maximal T-cell adhesion occurred with 1 ng/ml of DS. The levels of T-cell adhesion to ECM that were induced by the tested DS molecules resembled those induced by the prototypic chemokine, macrophage inflammatory protein 1beta (MIP-1beta). However, the kinetics of DS-induced T-cell adhesion to FN resembled that induced by phorbol myristate acetate (PMA), but not that induced by MIP-1beta. This adhesion appeared to involve beta1 integrin recognition and activation, and was associated with specific intracellular activation pathways. Although a first exposure of T cells to certain DS molecules appeared to result in cell adhesion, a subsequent exposure of T cells to pro-adhesive chemokines, such as MIP-1beta or RANTES, but not to other pro-adhesive stimuli, for example interleukin-2 or CD3 cross-linking, resulted in inhibition of T-cell adhesion to and chemotactic migration through FN. Hence, we propose that the breakdown products of tissues generated by inflammatory enzymes are part of an intrinsic functional programme, and not necessarily molecular waste. Moreover, because the DS molecules exert their modulatory functions within a limited time, it appears that the historical encounters of the tissue-invading cells with the constituents of inflamed loci may dictate the cells' behaviour upon subsequent exposure to proinflammatory mediators.
<title>Proton beam deflection using silicon crystal at the KEK proton synchrotron</title> (2007)

An experiment on deflection of a proton beam using a Silicon crystal was performed for the first time in Japan at the 12-GeV Proton Synchrotron of KEK. The (111) plane of the crystal was used to deflect a 12 GeV proton beam at an angle of 32.6 mrad. The beam extraction efficiency of the crystal was reached 13%. The divergence of the proton beam can be identified by comparison of the experimental data with simulated results.
Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption (2023)

Optical spectrometer apparatus, systems, and methods for analysis of carbon-14 including a resonant optical cavity configured to accept a sample gas including carbon-14, an optical source configured to deliver optical radiation to the resonant optical cavity, an optical detector configured to detect optical radiation emitted from the resonant cavity and to provide a detector signal; and a processor configured to compute a carbon-14 concentration from the detector signal, wherein computing the carbon-14 concentration from the detector signal includes fitting a spectroscopic model to a measured spectrogram, wherein the spectroscopic model accounts for contributions from one or more interfering species that spectroscopically interfere with carbon-14.
LINC: a common theory of transform and subband coding (1993)

A common theory of lapped orthogonal transforms (LOTs) and critically sampled filter banks, called L into N coding (LINC), is presented. The theory includes a unified analysis of both coding methods and identity relations between the transform, inverse transform, analysis filter bank, and synthesis filter bank. A design procedure for LINC analysis/synthesis systems, which satisfy the conditions for perfect reconstruction, is developed. The common LINC theory is used to define an ideal LINC system which is used, together with the power spectral density of the input signal, to calculate theoretical bounds for the coding gain. A generalized overlapping block transform (OBT) with time domain aliasing cancellation (TDAC) is used to approximate the ideal LINC. A generalization of the OBT includes multiple block overlap and additional windowing. A recursive design procedure for windows of arbitrary lengths is presented. The coding gain of the generalized OBT is higher than that of the Karhunen-Loeve transform (KLT) and close to the theoretical bounds for LINC. In the case of image coding, the generalized OBT reduces the blocking effects when compared with the DCT.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ThePseudomonas aeruginosaQuorum-Sensing MoleculeN-(3-Oxododecanoyl)Homoserine Lactone Contributes to Virulence and Induces Inflammation In Vivo (2002)

Pseudomonas aeruginosa has two well-characterized quorum-sensing systems, Las and Rhl. These systems are composed of LuxR-type proteins, LasR and RhlR, and two acyl homoserine lactone (AHL) synthases, LasI and RhlI. LasI catalyzes the synthesis of N-(3-oxododecanoyl)homoserine lactone (3O-C12-HSL), whereas RhlI catalyzes the synthesis of N-butyryl-homoserine lactone. There is little known about the importance of AHLs in vivo and what effects these molecules have on eukaryotic cells. In order to understand the role of AHLs in vivo, we first tested the effects that deletions of the synthase genes in P. aeruginosa had on colonization of the lung. We demonstrate that in an adult mouse acute-pneumonia model, deletion of the lasI gene or both the lasI and rhlI genes greatly diminished the ability of P. aeruginosa to colonize the lung. To determine whether AHLs have a direct effect on the host, we examined the effects of 3O-C12-HSL injected into the skin of mice. In this model, 3O-C(12)-HSL stimulated a significant induction of mRNAs for the cytokines interleukin-1alpha (IL-1alpha) and IL-6 and the chemokines macrophage inflammatory protein 2 (MIP-2), monocyte chemotactic protein 1, MIP-1beta, inducible protein 10, and T-cell activation gene 3. Additionally, dermal injections of 3O-C12-HSL also induced cyclooxygenase 2 (Cox-2) expression. The Cox-2 enzyme is important for the conversion of arachidonic acid to prostaglandins and is associated with edema, inflammatory infiltrate, fever, and pain. We also demonstrate that 3O-C12-HSL activates T cells to produce the inflammatory cytokine gamma interferon and therefore potentially promotes a Th1 environment. Induction of these inflammatory mediators in vivo is potentially responsible for the significant influx of white blood cells and subsequent tissue destruction associated with 3O-C12-HSL dermal injections. Therefore, the quorum-sensing systems of P. aeruginosa contribute to its pathogenesis both by regulating expression of virulence factors (exoenzymes and toxins) and by inducing inflammation.
Characterization of 3C-SiC Films Grown on 4H- and 6H-SiC Substrate Mesas during Step-Free Surface Hetero-Epitaxy (2003)

This paper reports detailed structural characterization of 3C-SiC heteroepitaxial films grown on 4H- and 6H-SiC mesa surfaces. 3C-SiC heterofilms grown by the "step-free surface heteroepitaxy" process, free of double-positioning boundary (DPB) and stacking-fault (SF) defects, were compared to less-optimized 3C-SiC heterofilms using High Resolution X-ray Diffraction (HRXRD), High Resolution Cross-sectional Transmission Electron Microscopy (HRXTEM), molten potassium hydroxide (KOH) etching, and dry thermal oxidation. The results suggest that step free surface heteroepitaxy enables remarkably benign partial lattice mismatch strain relief during heterofilm growth.
Learning real-time MRF inference for image denoising (2009)

Many computer vision problems can be formulated in a Bayesian framework with Markov Random Field (MRF) or Conditional Random Field (CRF) priors. Usually, the model assumes that a full Maximum A Posteriori (MAP) estimation will be performed for inference, which can be really slow in practice. In this paper, we argue that through appropriate training, a MRF/CRF model can be trained to perform very well on a suboptimal inference algorithm. The model is trained together with a fast inference algorithm through an optimization of a loss function on a training set containing pairs of input images and desired outputs. A validation set can be used in this approach to estimate the generalization performance of the trained system. We apply the proposed method to an image denoising application, training a Fields of Experts MRF together with a 1-4 iteration gradient descent inference algorithm. Experimental validation on unseen data shows that the proposed training approach obtains an improved benchmark performance as well as a 1000-3000 times speedup compared to the Fields of Experts MRF trained with contrastive divergence. Using the new approach, image denoising can be performed in real-time, at 8 fps on a single CPU for a 256 × 256 image sequence, with close to state-of-the-art accuracy.
Improving the Color Constancy of Prints by Ink Design (2005)

A computer simulation was performed to investigate optimal four- and five-ink sets in order to minimize color inconstancy while maintaining a large color gamut. The effect of including a spectrally-flat black ink on color constancy was explored. The relationship between ink shape and the color constancy of prints was also analyzed. The results show that the ink shape in the middle wavelength region is very important for the color constancy of prints. The minimum and maximum color inconstancy indices that the different ink sets can achieve, which were optimized by different objective functions, were explored. The results show that color constancy can be improved by both ink design and lookup table creation.
Challenges in post-silicon verification of IBM&#x2019;s Cell/B.E. and other game processors (2007)

Recent IBM processors used in various computer systems including gaming systems are a very aggressive design, addressing three main challenges of the processor design -Memory wall, Power wall and ILP wall. To break these walls the some designs utilized multi threaded, multi core and yet high frequency. These kinds of designs increased the complexity of the test stream generation for processor verification especially in a stress test environment. Moreover Cell Broadband Engine <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> (Cell/B.E.) utilizes heterogeneous multi core, multi threaded with high. This further increased the complexity of the verification. This paper describes some of the scenarios, the Post Silicon Verification team addressed in their effort of verification of the Cell/B.E. and other game processors.
ChemInform Abstract: Reactions of N‐Chloro β‐Lactams. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impacts of plasma process-induced damage on ultra-thin gate oxide reliability (2002)

The leakage current induced by the plasma charging damage in ultra-thin gate oxide is characterized from the time dependence of leakage current under constant-voltage stress for both stress-polarities. Based on the electron trapping model, the trap site density generated by the plasma processing is calculated. It is found that an annealing process recovers dominantly the plasma process-induced traps in the oxide, rather than the Si-SiO/sub 2/ interface states.
Organic Thin Film Transistors from a Soluble Oligothiophene Derivative Containing Thermally Removable Solubilizing Groups (2004)

A symmetrical alpha,omega-substituted sexithiophene derivative containing thermally removable branched ester solubilizing groups has been prepared. These oligomers can be solution cast into thin films and then thermolyzed to remove the solubilizing group, leaving short pendant alkene groups on the oligomer. Device testing of thin film transistors shows an increase in hole mobility from 1 x 10-5 cm2/(V s) with on/off ratios of approximately 100 before thermolysis to 5 x 10-2 cm2/(V s) with on/off ratios >105 after thermolysis. This method offers an attractive route to easily processed and highly performing thiophene oligomers.
Detection and extraction of endosulfan by metal nanoparticles (2003)

One of the most common pesticides in the developing world, endosulfan, can be detected in ppm levels using gold nanoparticles. Endosulfan adsorbs on the nanoparticle surface and upon interaction for a long time, the nanoparticles precipitate from the solution. Interaction with silver is weak, yet adsorption occurs leading to removal of endosulfan from the solution. A multilayer assembly of gold nanoparticles prepared on a glass substrate shows excellent spectrophotometric response suggesting potential applications.
DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas (2021)

Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets might be important. <i>Bam</i>HI-A rightward frame 1 (BARF1) is an EBV antigen that is highly expressed in EBV<sup>+</sup> nasopharyngeal carcinoma (NPC) and EBV-associated gastric carcinoma (EBVaGC). BARF1 antigen can transform human epithelial cells <i>in vivo.</i> BARF1-specific antibodies and cytotoxic T cells were detected in some EBV<sup>+</sup> NPC patients. However, BARF1 has not been evaluated as an antigen in the context of therapeutic immunization. Its possible importance in this context is unclear. Here, we developed a synthetic-DNA-based expression cassette as immunotherapy targeting BARF1 (pBARF1). Immunization with pBARF1 induced potent antigen-specific humoral and T cell responses <i>in vivo</i>. Immunization with pBARF1 plasmid impacted tumor progression through the induction of CD8<sup>+</sup> T cells in novel BARF1<sup>+</sup> carcinoma models. Using an <i>in vivo</i> imaging system, we observed that pBARF1-immunized animals rapidly cleared cancer cells. We demonstrated that pBARF1 can induce antigen-specific immune responses that can impact cancer progression. Further study of this immune target is likely important as part of therapeutic approaches for EBV<sup>+</sup> malignancies.
Structural and Photophysical Studies of Phosphorescent Three-Coordinate Copper(I) Complexes Supported by an N-Heterocyclic Carbene Ligand (2012)

A series of four neutral luminescent three-coordinate Cu(I) complexes (IPr)Cu(N∧N), where IPr is a monodentate N-heterocyclic carbene (NHC) ligand (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) and N∧N denotes monoanionic pyridyl-azolate ligands, have been synthesized and characterized. A monomeric, three-coordinate geometry, best described as distorted trigonal planar, has been established by single-crystal X-ray analyses for three of the derivatives. In contrast to the previously reported (IPr)Cu(N∧N) complexes, the compounds described here display a perpendicular orientation between the chelating N∧N ligands and the imidazolylidene ring of the carbene ligand. The geometrical preferences revealed by X-ray crystallography correlate well with the NMR data. The conformational behavior of the complexes, investigated by variable-temperature 1H NMR spectroscopy, indicate free rotation about the CNHC–Cu bond in solution. The complexes display broad, featureless luminescence at both room temperature and 77 K, with emission maxima that vary between 555 and 632 nm depending on sample conditions. Luminescence quantum efficiencies of the complexes in solution (Φ ≤ 17%) increase markedly in the solid state (Φ ≤ 62%). On the basis of time-dependent density functional theory (TD-DFT) calculations and the experimental data, luminescence is assigned to phosphorescence from a metal-to-ligand charge-transfer (MLCT) triplet state admixed with ligand-centered (LC) character.
Multi-strange baryon production in pp collisions at s=7 TeV with ALICE (2012)

A measurement of the multi-strange Ξ− and Ω− baryons and their antiparticles by the ALICE experiment at the CERN Large Hadron Collider (LHC) is presented for inelastic proton–proton collisions at a centre-of-mass energy of 7 TeV. The transverse momentum (pT) distributions were studied at mid-rapidity (|y|<0.5) in the range of 0.6<pT<8.5 GeV/c for Ξ− and Ξ¯+ baryons, and in the range of 0.8<pT<5 GeV/c for Ω− and Ω¯+. Baryons and antibaryons were measured as separate particles and we find that the baryon to antibaryon ratio of both particle species is consistent with unity over the entire range of the measurement. The statistical precision of the current data has allowed us to measure a difference between the mean pT of Ξ− (Ξ¯+) and Ω− (Ω¯+). Particle yields, mean pT, and the spectra in the intermediate pT range are not well described by the PYTHIA Perugia 2011 tune Monte Carlo event generator, which has been tuned to reproduce the early LHC data. The discrepancy is largest for Ω− (Ω¯+). This PYTHIA tune approaches the pT spectra of Ξ− and Ξ¯+ baryons below pT<0.85 GeV/c and describes the Ξ− and Ξ¯+ spectra above pT>6.0 GeV/c. We also illustrate the difference between the experimental data and model by comparing the corresponding ratios of (Ω−+Ω¯+)/(Ξ−+Ξ¯+) as a function of transverse mass.