gebhart/patrepeval huggingface dataset:
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice (2008)

We provide further evidence that NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis. Therefore, NPS receptor ligands may represent innovative drugs for the treatment of sleep and anxiety disorders.
Bacteriocin Protein BacL1of Enterococcus faecalis Targets Cell Division Loci and Specifically Recognizes l-Ala2-Cross-Bridged Peptidoglycan (2014)

Bacteriocin 41 (Bac41) is produced from clinical isolates of Enterococcus faecalis and consists of two extracellular proteins, BacL1 and BacA. We previously reported that BacL1 protein (595 amino acids, 64.5 kDa) is a bacteriolytic peptidoglycan D-isoglutamyl-L-lysine endopeptidase that induces cell lysis of E. faecalis when an accessory factor, BacA, is copresent. However, the target of BacL1 remains unknown. In this study, we investigated the targeting specificity of BacL1. Fluorescence microscopy analysis using fluorescent dye-conjugated recombinant protein demonstrated that BacL1 specifically localized at the cell division-associated site, including the equatorial ring, division septum, and nascent cell wall, on the cell surface of target E. faecalis cells. This specific targeting was dependent on the triple repeat of the SH3 domain located in the region from amino acid 329 to 590 of BacL1. Repression of cell growth due to the stationary state of the growth phase or to treatment with bacteriostatic antibiotics rescued bacteria from the bacteriolytic activity of BacL1 and BacA. The static growth state also abolished the binding and targeting of BacL1 to the cell division-associated site. Furthermore, the targeting of BacL1 was detectable among Gram-positive bacteria with an L-Ala-L-Ala-cross-bridging peptidoglycan, including E. faecalis, Streptococcus pyogenes, or Streptococcus pneumoniae, but not among bacteria with alternate peptidoglycan structures, such as Enterococcus faecium, Enterococcus hirae, Staphylococcus aureus, or Listeria monocytogenes. These data suggest that BacL1 specifically targets the L-Ala-L-Ala-cross-bridged peptidoglycan and potentially lyses the E. faecalis cells during cell division.
On Detection of Changes in Categorical Data (2012)

We consider situations where the observed data is of categorical type and the underlying parameters are subject to abrupt changes of unpredictable magnitude at unknown points in time. We derive change-point detection schemes based on generalized likelihood ratio tests and develop procedures for their design and analysis. We also discuss problems related to parameter estimation for categorical data in the presence of abrupt changes. We illustrate use of the proposed methodology for fault characterization and monitoring in the semiconductor industry.
A phase II randomized trial of observation versus stereotactic ablative radiation for oligometastatic prostate cancer (ORIOLE). (2017)

TPS5094 Background: ORIOLE is a randomized, non-blinded Phase II interventional study evaluating the safety and efficacy of SBRT in biochemically recurrent, oligometastatic, hormone-sensitive prostate cancer at 3 centers in the US. Patients will be stratified by clinical characteristics and randomized 2:1 to SBRT or observation. The primary clinical endpoint is progression at 6 months defined by PSA increase, radiologic or clinical evidence, ADT initiation, or death from any cause. Secondary endpoints include local control at 6 months, SBRT-associated toxicity and quality of life, and ADT-free survival. Imaging and laboratory correlates will characterize, in isolation, the effects of SBRT on oligometastatic disease. Methods: Eligible patients are hormone-sensitive, have undergone prior definitive treatment and recurred with 1-3 asymptomatic bone or soft tissue metastases diagnosed within 6 months, PSA doubling time (PSADT) &lt; 15 months, ECOG performance status ≤ 2, and normal organ and marrow function. Minimization will be used to balance assignment by primary intervention, prior ADT, and PSADT. Accrual of 54 patients provides 85% power to detect a decrease in progression rate from 80% to 40% with type I error = 0.05 using one-sided Fisher’s exact test. Hazard ratios and Kaplan-Meier estimates of progression free survival, ADT free survival, and time to locoregional and distant progression will be calculated based on intention-to-treat. Local control will be assessed using RECIST 1.1 criteria. Withdrawal prior to 6 months will be counted as progression. Adverse events will be summarized and quality of life pre- and post-SBRT will be measured by Brief Pain Inventory. The investigational targeted imaging agent 18 F-DCFPyL will be compared to bone scan and CT for identifying oligometastases before SBRT and monitoring disease response following SBRT. Biological alterations induced by SBRT will be investigated using circulating tumor cell analysis, deep sequencing of circulating tumor DNA, and T-cell repertoire profiling. A hereditary cancer assay will inform efforts to advance personalized screening and therapy. Clinical trial information: NCT02680587.
Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group (2010)

Abstract The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and presentation to T and B cells. This Report summarizes the key points of that discussion, and subsequent discussions with the Chairs of the other Enterprise Working Groups, the Enterprise Science Committee, the Enterprise Council and the broader scientific community during open sessions at scientific conferences.
Dichloro(D-methionine-N,S)platinum(II) at 130 K (2001)

The asymmetric unit of the title compound, [PtCl2(C5H11NO2S)], a D-methionine derivative, contains two molecules with opposite chirality at the S atoms. The amino acid acts as a bidentate ligand and coordinates simultaneously through the N (amino) and S (thioether) atoms. The molecules are packed in pairs which are connected through two hydrogen bonds between the protonated carboxyl groups, with O.O distances of 2.633 (10) and 2.663 (12) A.
Challenges in Detection of Serum Oncoprotein: Relevance to Breast Cancer Diagnostics (2021)

Breast cancer is a highly prevalent malignancy that shows improved outcomes with earlier diagnosis. Current screening and monitoring methods have improved survival rates, but the limitations of these approaches have led to the investigation of biomarker evaluation to improve early diagnosis and treatment monitoring. The enzyme-linked immunosorbent assay (ELISA) is a specific and robust technique ideally suited for the quantification of protein biomarkers from blood or its constituents. The continued clinical relevancy of this assay format will require overcoming specific technical challenges, including the ultra-sensitive detection of trace biomarkers and the circumventing of potential assay interference due to the expanding use of monoclonal antibody (mAb) therapeutics. Approaches to increasing the sensitivity of ELISA have been numerous and include employing more sensitive substrates, combining ELISA with the polymerase chain reaction (PCR), and incorporating nanoparticles as shuttles for detection antibodies and enzymes. These modifications have resulted in substantial boosts in the ability to detect extremely low levels of protein biomarkers, with some systems reliably detecting antigen at sub-femtomolar concentrations. Extensive utilization of mAb therapies in oncology has presented an additional contemporary challenge for ELISA, particularly when both therapeutic and assay antibodies target the same protein antigen. Resolution of issues such as epitope overlap and steric hindrance requires a rational approach to the design of diagnostic antibodies that takes advantage of modern antibody generation pipelines, epitope binning techniques and computational methods to strategically target biomarker epitopes. This review discusses technical strategies in ELISA implemented to date and their feasibility to address current constraints on sensitivity and problems with interference in the clinical setting. The impact of these recent advancements will depend upon their transformation from research laboratory protocols into facile, reliable detection systems that can ideally be replicated in point-of-care devices to maximize utilization and transform both the diagnostic and therapeutic monitoring landscape.
ChemInform Abstract: Amine‐Catalyzed Intramolecular Imidization of Alkyl and Aryl Phthalamates. Kinetics and Mechanism in Deuteriated Chloroform. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ocular neovascularisation and excessive vascular permeability (2004)

Diseases complicated by vascular leakage and/or neovascularisation in the eye are responsible for the vast majority of visual morbidity and blindness in developed countries. The molecular signals that control vascular permeability and neovascularisation in the eye are being defined. Members of the vascular endothelial growth factor (VEGF) family are key stimulators that interact with two tyrosine kinase receptors, VEGF receptor (VEGFR)1 and 2; binding to two other receptors that lack tyrosine kinase activity, the neuropilins, is also important. Signalling through the VEGF pathway is modulated by the Tie2 receptor and its binding partners, the angiopoietins. Each of the participants in these two signalling pathways provides a potential target for intervention. Several proteins with antiangiogenic activity balance the stimulators and the outcome is determined by the net balance. Endostatin suppresses vascular permeability as well as ocular neovascularisation, suggesting that vascular leakage may also be regulated by counteracting proteins. Gene transfer provides a useful way to influence these balances. Clinical trials are underway to test whether these mechanisms can be translated into new therapies.
Multicomponent Cascade Transformation of d-Glucal to Furan-Appended Triazole Glycoconjugates (2010)

Novel one-pot three- and four-component transformations of D-glucal to furan-based hydroxy triazole glycoconjugates have been achieved by sequential addition of reagents in the presence of Cu(OTf)(2)-Cu powder as catalysts. In general the carbohydrate-derived products were formed with high diastereomeric purity.
Exploring the impact of media and information on self-reported intentions to vaccinate against COVID-19: A qualitative interview-based study (2022)

COVID-19 vaccine hesitancy prevents universal immunization and contradictory messages in media are a source of concern and fear. The success of future vaccine campaigns will depend upon authorities' ability to disseminate accessible, detailed, and consistent information promoting public confidence.
PRBS testing of analogue circuits (1992)

This paper presents a time-domain approach, for testing analogue circuits that can be implemented on a digital tester. The time-domain testing strategy proposed is based on the excitation of the analogue circuit-under-test (CUT) with a sequence of pulses, and subsequent measurement of the transient response at the output node/s. Both the transient voltage at the output node/s and the transient current (Idd) of the supply current are measured. The major advantage of the transient response is that it contains all the necessary information about the CUT. This information can then be processed in a number of ways to extract measures of various parameters. In this case the authors process the transient response data to establish whether the circuit is faulty or not (i.e. Go/No-Go). The test sequence to be applied to an analogue CUT is a pseudo-random binary sequence (PRBS). The PRBS is chosen because it can be readily generated by a digital tester, such sequences have well defined properties and can be used to extract the impulse response of the CUT if required. The autocorrelation function of a PRBS signal is triangular with a base-width equal to two clock periods, which is a very good approximation of the impulse function. >
Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds (2019)

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional (3D) ice-templated collagen scaffolds. However, the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been explored. Here, we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide) microparticles. We probe the effects of subsequent <i>N</i>-(3-dimethylaminopropyl)-<i>N</i>'-ethylcarbodiimide hydrochloride crosslinking on protein release, using microparticles with different internal protein distributions. Fluorescein isothiocyanate labelled bovine serum albumin is used as a model protein drug. The scaffolds display a homogeneous microparticle distribution, and a reduction in pore size and percolation diameter with increased microparticle addition, although these values did not fall below those reported as necessary for cell invasion. The protein distribution within the microparticles, near the surface or more deeply located within the microparticles, was important in determining the release profile and effect of crosslinking, as the surface was affected by the carbodiimide crosslinking reaction applied to the scaffold. Crosslinking of microparticles with a high proportion of protein at the surface caused both a reduction and delay in protein release. Protein located within the bulk of the microparticles, was protected from the crosslinking reaction and no delay in the overall release profile was seen.
Using Interactive Connectivity Establishment (ICE) with Session Description Protocol (SDP) offer/answer and Session Initiation Protocol (SIP) (2013)

This document describes how Interactive Connectivity Establishment
(ICE) is used with Session Description Protocol (SDP) offer/answer and
Session Initiation Protocol (SIP).
Comparison of N2 and NH3 Plasma Passivation Effects on Polycrystalline Silicon Thin-Film Transistors (1998)

The passivation effects of pure N 2 plasma on polycrystalline silicon (poly-Si) thin-film transistors (TFTs) have been studied and compared with those of NH 3 plasma. We found that, similar to the recently-proposed NH 3 plasma passivation, N 2 plasma passivation can also effectively improve device parameters such as field effect mobility, threshold voltage, subthreshold swing, off current, and on/off current ratio. While the improvement of NH 3 -passivated devices can be attributed to both hydrogen and nitrogen passivation effects, nitrogen passivation alone is mainly responsible for the improvement of N 2 -passivated devices. In addition, we found that N 2 -passivated devices exhibit much better hot-carrier reliability than NH 3 -passivated devices. The better hot-carrier reliability of N 2 -passivated devices can be explained by the formation of strong Si–N bonds which are difficult to break, while effectively eliminating the weaker N–H bonds, which are inevitable in NH 3 -passivated devices. The results of a Fourier transform infrared (FTIR) spectrum analysis performed in this study are consistent with this proposition.
A robust and efficient power series method for tracing PV curves (2015)

Estimating the voltage collapse point of a power grid is an important problem in power flow analysis. In this paper, we propose a novel power series method (PSM) for tracing the power-voltage (PV) curve and estimating the collapse point. By expanding the power flow equation into power series, a new point on the PV curve can be accurately extrapolated based on a previously solved point. Both forward stepping and backward stepping are proposed so that the proposed PSM can trace both the upper and lower halves of the PV curve. The collapse point is estimated as the intersection of the two half curves. Compared with the conventional continuation method, our PSM is numerically more robust. Compared with the conventional embedding method, our PSM offers superior accuracy and low computational cost.
Performance Evaluation Strategies for Eye Gaze Estimation Systems with Quantitative Metrics and Visualizations (2018)

An eye tracker's accuracy and system behavior play critical roles in determining the reliability and usability of eye gaze data obtained from them. However, in contemporary eye gaze research, there exists a lot of ambiguity in the definitions of gaze estimation accuracy parameters and lack of well-defined methods for evaluating the performance of eye tracking systems. In this paper, a set of fully defined evaluation metrics are therefore developed and presented for complete performance characterization of generic commercial eye trackers, when they operate under varying conditions on desktop or mobile platforms. In addition, some useful visualization methods are implemented, which will help in studying the performance and data quality of eye trackers irrespective of their design principles and application areas. Also the concept of a graphical user interface software named GazeVisual v1.1 is proposed that would integrate all these methods and enable general users to effortlessly access the described metrics, generate visualizations and extract valuable information from their own gaze datasets. We intend to present these tools as open resources in future to the eye gaze research community for use and further advancement, as a contribution towards standardization of gaze research outputs and analysis.
ChemInform Abstract: The Production and Uses of Optically Pure Natural and Unnatural Amino Acids (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2015)

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s = 8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb -1 . No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (R c ) of approximately 30.
Micromechanics-guided development of a slag/fly ash-based strain-hardening geopolymer composite (2020)

Strain-hardening geopolymer composite (SHGC) lately emerged as a promising alternative to traditional strain-hardening cementitious composite with added advantages of industrial by-product utilization and enhanced sustainability. However, as the design of SHGC requires multi-factor optimization, the application of traditional trial-and-error method is inefficient and hinders the development of this material. This paper aims at the development of a slag/fly ash-based SHGC with low slag content using a micromechanical model to guide the composite mixture design. To this end, experimentally characterized physical properties of fiber, matrix and interface are used as input for the micromechanical model, which serves as a predictive tool for the tensile performance of SHGC. Following the guidance, a slag/fly ash-based SHGC with tensile strain capacity of 4.8% and ultimate tensile strength above 3.8 MPa was systematically developed. The feasibility and effectiveness of using micromechanics as the design basis of SHGC are demonstrated and experimentally verified.
Inhibitory Effect of the Gallotannin Corilagin on Dextran Sulfate Sodium-Induced Murine Ulcerative Colitis (2013)

The therapeutic effect of corilagin (1) was evaluated in an acute colitis model induced by dextran sulfate sodium (DSS) in mice, and the mechanism of action was investigated in this study. Animals were challenged with 2% DSS drinking water for 5 consecutive days and then intraperitoneally treated with 1 (7.5, 15, and 30 mg/kg) daily for 7 days. It was found that 1 significantly decreased the disease activity index, inhibited the shortening of colon length, reduced colon tissue damage, and suppressed myeloperoxidase activity. Moreover, 1 greatly suppressed the secretion of TNF-α, IL-6, and IL-1β, inhibited the degradation of IκB α, and down-regulated expression of cleaved caspase-3 and cleaved caspase-9 in colon tissues of DSS-treated mice. These findings demonstrated that 1 exerts a protective effect on DSS-induced colitis, and its underlying mechanisms are associated with inhibition of the NF-κB pathway that mitigates colon inflammatory responses and apoptosis of intestinal epithelial cells.
StyleBlit: Fast Example-Based Stylization with Local Guidance (2018)

We present StyleBlit---an efficient example-based style transfer algorithm that can deliver high-quality stylized renderings in real-time on a single-core CPU. Our technique is especially suitable for style transfer applications that use local guidance - descriptive guiding channels containing large spatial variations. Local guidance encourages transfer of content from the source exemplar to the target image in a semantically meaningful way. Typical local guidance includes, e.g., normal values, texture coordinates or a displacement field. Contrary to previous style transfer techniques, our approach does not involve any computationally expensive optimization. We demonstrate that when local guidance is used, optimization-based techniques converge to solutions that can be well approximated by simple pixel-level operations. Inspired by this observation, we designed an algorithm that produces results visually similar to, if not better than, the state-of-the-art, and is several orders of magnitude faster. Our approach is suitable for scenarios with low computational budget such as games and mobile applications.