gebhart/patrepeval huggingface dataset:
Effects of Infection on Oxygen Consumption and Core Temperature in Experimental Thermal Injury (1988)

Oxygen consumption (VO2) and colonic temperature (Tc) were measured in groups of rats before and after 30% total body surface, full thickness burns. Some wounds were seeded with Pseudomonas aeruginosa or Staphylococcus epidermidis, and some seeded wounds were treated with Sulfamylon or Silvadene. Three groups became bacteremic (B) during the 2-3 week period of observation. At an ambient temperature (Ta) of 32 C, VO2 of the B group rose from 0.83 +/- 0.01 to 1.20 +/- 0.01 ml/hr/g (mean +/- S.E., p less than 0.001) versus 0.81 +/- 0.01 to 0.99 +/- 0.02 for nine nonbacteremic (NB) groups (p less than 0.001). Tc increased only in the B groups--from 36.8 +/- 0.1 to 37.7 +/- 0.1 C (p less than 0.001). In the second or third week postinjury, VO2 of the NB rats was reduced when Ta was increased to 34 C; Tc followed changes in Ta. Sulfamylon lowered VO2 of P. aeruginosa seeded, NB rats. The metabolic cost of wound contamination appeared to vary with bacterial strain. The metabolic effects of infection appear to be a continuum, beginning with a modest rise in VO2 and progressing to greater increases in VO2 and Tc with wound invasion and systemic infection.
More Easily Cultivated Than Identified: Classical Isolation With Molecular Identification of Vaginal Bacteria (2016)

We isolated a diverse set of novel and clinically significant anaerobes from the human vagina using conventional approaches with systematic molecular identification. Several previously "uncultivated" bacteria are amenable to conventional cultivation.
Evaluating Hazard Mitigations with Dependability Cases (2009)

There is growing interest in using a structure of claims, arguments, and evidence to ex-plain why all critical software hazards have been eliminated or adequately mitigated in mis-sion-critical and safety-critical systems. Such a structure has been called a dependability case, an assurance case, or a (goal-structured) safety case. Dependability cases are sometimes viewed as adding no extra value, e.g., given an existing hazard analysis, what is the added value of a dependability case showing how the hazard is mitigated? In this paper we present an example to show the value a dependability case adds to a traditional hazard analysis. I.
Differential Excretory/Secretory Proteome of the Adult Female and Male Stages of the Human Blood Fluke, Schistosoma mansoni (2022)

Intricate molecular communication between schistosome flatworms and their mammalian host, as well as between paired male and female schistosomes has shaped the secreted proteome of these flatworms. Whereas the schistosome egg is responsible for the disease manifestations of chronic schistosomiasis, the long lived, adult female and male stages also release different mediators including glycans, lipids, proteins and small molecules, known as excretory/secretory products (ESPs), that facilitate their survival. Given their importance, deeper analysis focused on analyzing the ESPs from adult schistosomes would likely be informative, beyond current understanding of the complement of ESP proteins. Here, taking advantage of highly accurate and sensitive mass spectrometers, the excretory/secretory proteome from cultured <i>Schistosoma mansoni</i> male or female adult worms was identified, quantified, compared and contrasted using a label-free proteomic approach. Approximately 1,000 proteins were identified, from which almost 800 could be quantified. Considering the proteins uniquely identified and proteins with a significantly regulated expression pattern in male or female flukes, a total of 370 and 140 proteins were uniquely or more abundantly secreted by males and females, respectively. Using functional analysis networks showing the gene ontology terms and KEGG pathways with the highest significance, we observed that male schistosomes secrete proteins related to carbohydrate metabolism and cytoskeletal organization more abundantly than females, while female worms secreted more hydrolases and proteins involved in cellular homeostasis than males. This analysis doubles the number of reported excreted/secreted proteins from <i>S. mansoni</i>, contributing to deeper understanding of the host-parasite interaction and parasitism. Furthermore, these findings expand potential vaccine and diagnostic candidates for this neglected tropical disease pathogen, and thereby also provide leads for novel intervention to control this disease and its transmission.
Tool Usage and Efficiency in an Online Test (2023)

In this study, we analyze data from the National Assessment of Education Progress (NAEP) digital test to understand how digital tool usage relates to the efficiency of answering the questions. Digital testing software provides students with on-screen tools such as calculators and scratchpads. We found that in the NAEP test, students who used the digital tools were slower in solving the problems, but more accurate when the question demanded the use of the tool. We also found that when students used the tool when it was not needed, they were more likely to be incorrect. Overall, our findings suggest that students need to be trained on both how to use the tools and when to use them so that they can make the most use of their testing time.
Data cleansing as a transient service (2010)

There is often a transient need within enterprises for data cleansing which can be satisfied by offering data cleansing as a transient service. Every time a data cleansing need arises it should be possible to provision hardware, software and staff for accomplishing the task and then dismantling the set up. In this paper we present such a system that uses virtualized hardware and software for data cleansing. We share actual experiences gained from building such a system.We use a cloud infrastructure to offer virtualized data cleansing instances that can be accessed as a service. We build a system that is scalable, elastic and configurable. Each enterprise has unique needs which makes it necessary to customize both the infrastructure and the cleansing algorithms to address these needs. In this paper we will present a system that is easily configurable to suit the data cleansing needs of an enterprise.
<title>Multiresolution color correction</title> (1998)

In this paper, a color correction system is embedded into a multiresolution representation with the goal of reducing the complexity of 3D look-up table transformations. A framework is assumed wherein the image undergoes a multiresolution decomposition, e.g. discrete wavelet transform, for the purpose of image compression or other processing. After the image is reconstructed from its multiresolution representation, color correction is usually required for rendering to a specific device. The color correction process is divided into two phases: a complex multidimensional transform (Phase 1), and a series of essentially 1-D transforms (Phase 2). Phase 1 correction is then moved within the multiresolution reconstruction process in such a way that a small subset of the image samples undergoes the multidimensional correction. Phase 2 correction is then applied to all image samples after the image is reconstructed to its full resolution. The recently proposed spatial CIELAB model is used to evaluate the algorithm. The computational cost incurred by the color correction is considerably reduced, with little loss in image quality.
Control System for Piezoelectric-Actuator-Based Tunable Evanescent-Mode Cavity Microwave Filters (2018)

A control system for automatic tuning of substrate-integrated, evanescent-mode cavity, microwave filters, with piezoelectric actuators, is developed. The system is based on an elegant sensing method using monitoring capacitors mounted on top of the actuators, where the digital value of them is directly measured. The system first requires us to characterize the resonators in the filter and then can automatically tune the filter without any extra instrument. Characterization is used to circumvent the hysteresis and creeping effects of the piezoelectric actuators. This procedure extracts a unique frequency-capacitance relationship, which is modeled using a quadratic polynomial and saved into the system for tuning. Polynomial coefficients, extracted from the characterization data, are utilized to implement a closed-loop feedback control algorithm for the standalone tuning operation. The capability of the control system in automatically tuning a variety of microwave filters using this methodology is experimentally demonstrated.
Ledipasvir and Sofosbuvir for 8 or 12 Weeks for Chronic HCV without Cirrhosis (2014)

Ledipasvir-sofosbuvir for 8 weeks was associated with a high rate of sustained virologic response among previously untreated patients with HCV genotype 1 infection without cirrhosis. No additional benefit was associated with the inclusion of ribavirin in the regimen or with extension of the duration of treatment to 12 weeks. (Funded by Gilead Sciences; ION-3 ClinicalTrials.gov number, NCT01851330.).
Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia (2010)

Corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia are all part of a disease spectrum that includes common cognitive impairment and movement disorders. The aim of this study was to characterize brain cholinergic deficits in these disorders. We measured brain acetylcholinesterase activity by [11C] N-methylpiperidin-4-yl acetate and positron emission tomography in seven patients with corticobasal syndrome (67.6+/-5.9 years), 12 with progressive supranuclear palsy (68.5+/-4.1 years), eight with frontotemporal dementia (59.8+/-6.9 years) and 16 healthy controls (61.2+/-8.5 years). Two-tissue compartment three-parameter model and non-linear least squares analysis with arterial input function were performed. k3 value, an index of acetylcholinesterase activity, was calculated voxel-by-voxel in the brain of each subject. The k3 images in each disease group were compared with the control group by using Statistical Parametric Mapping 2. Volume of interest analysis was performed on spatially normalized k3 images. The corticobasal syndrome group showed decreased acetylcholinesterase activity (k3 values) in the paracentral region, frontal, parietal and occipital cortices (P<0.05, cluster corrected). The group with progressive supranuclear palsy had reduced acetylcholinesterase activity in the paracentral region and thalamus (P<0.05, cluster corrected). The frontotemporal dementia group showed no significant differences in acetylcholinesterase activity. Volume of interest analysis showed mean cortical acetylcholinesterase activity to be reduced by 17.5% in corticobasal syndrome (P<0.001), 9.4% in progressive supranuclear palsy (P<0.05) and 4.4% in frontotemporal dementia (non-significant), when compared with the control group. Thalamic acetylcholinesterase activity was reduced by 6.4% in corticobasal syndrome (non-significant), 24.0% in progressive supranuclear palsy (P<0.03) and increased by 3.3% in frontotemporal dementia (non-significant). Both corticobasal syndrome and progressive supranuclear palsy showed brain cholinergic deficits, but their distribution differed somewhat. Significant brain cholinergic deficits were not seen in frontotemporal dementia, which may explain the unresponsiveness of this condition to cholinergic modulation therapy.
Absent CD44v6 Expression is an Independent Predictor of Poor Urothelial Bladder Cancer Outcome (2010)

Absent CD44v6 expression is an independent adverse predictor of urothelial bladder cancer recurrence and overall survival. Routine evaluation of CD44v6 expression may allow the identification of high risk patients who require more intensive surveillance or aggressive therapy. Targeting of CD44v6 with monoclonal antibodies may provide new avenues for urothelial bladder cancer imaging and treatment.
Studies on the Precise Chemical Synthesis of Human Glycoproteins (2015)

Abstract Our research group demonstrated the semi-synthesis of complex-type biantennary sialyloligosaccharide-library by means of branch-specific glycosidase and several sialyltransferase reactions toward complex-type H2N-Asn-(biantennary compex-type sialyloligosaccharide)-COOH isolated from egg yolk at over a gram scale. This methodology yielded 35 kinds of homogeneous complex-type oligosaccharides. Using this oligosaccharide library, an efficient Boc solid phase peptide synthesis (SPPS) of acid labile sialylglycopeptide-α-thioester was demonstrated. Our research group showed that the sialoside in which the carboxylic acid is protected with a phenacyl group is stable under strong acidic conditions, and this critical finding enabled us to demonstrate the first Boc-SPPS for the synthesis of a sialylglycopeptide-α-thioester. Using both a synthetic method of sialylglycopeptide-α-thioester and native chemical ligation (NCL), our research group synthesized several glycoproteins such as chemokine MCP-3, three kinds of erythropoietin analogues, and interferon-ß. Our research group also demonstrated a unique synthesis that was an intentional synthesis of homogeneous misfolded glycoproteins bearing M9-high-mannose-type oligosaccharide. This unique synthetic misfolded-glycoprotein is useful for the purpose of uncovering the mechanism of molecular recognition in glycoprotein quality control (GQC) in the endoplasmic reticulum (ER). This account discusses the function of the oligosaccharides of glycoproteins based on our research findings.
Individual Preference Probability Modeling and Parameterization for Video Content in Wireless Caching Networks (2019)

Caching of video files at the wireless edge, i.e., at the base stations or on user devices, is a key method for improving wireless video delivery. While global popularity distributions of video content have been investigated in the past and used in a variety of caching algorithms, this paper investigates the statistical modeling of the individual user preferences. With individual preferences being represented by probabilities, we identify their critical features and parameters and propose a novel modeling framework by using a genre-based hierarchical structure as well as a parameterization of the framework based on an extensive real-world data set. Besides, the correlation analysis between parameters and critical statistics of the framework is conducted. With the framework, an implementation recipe for generating practical individual preference probabilities is proposed. By comparing with the underlying real data, we show that the proposed models and generation approach can effectively characterize the individual preferences of users for video content.
Differential Antibody Responses to Plasmodium falciparum Invasion Ligand Proteins in Individuals Living in Malaria-Endemic Areas in Brazil and Cameroon (2007)

Antibody responses to malaria invasion ligands and proteins on the merozoite surface have been shown to interfere with red cell invasion and correlate with immunity to malaria. The current study is the first to characterize the antibody responses to EBA-140 and EBA-181, Plasmodium falciparum invasion ligands implicated in the alternative pathways of invasion, in age-matched populations of individuals living in endemic areas in both Brazil and Cameroon. Antibody responses to the proteins screened were different between populations. The African individuals reacted strongly with most fragments of these two EBAs, while the majority of the individuals from Mato Grosso, Brazil, reacted weakly and those from the Amazon had elevated responses to these EBA proteins. When compared with the responses against MSP-1(19) and EBA-175, it appeared that the Brazilian population has a variable ability to recognize P. falciparum invasion ligand proteins and that these responses are distinct from the African population.
Fig.S1 to S7 from CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy (2023)

&lt;p&gt;Fig.S1: CD73 prognosis in untreated breast cancer; Fig. S2: CD73 prognosis in METABRIC; Fig. S3: Multivariate analysis; Fig. S4: CD73 expression in H2N100 and TUBO; Fig. S5: H2N100 and TUBO survival data; Fig. S6: Combined treatment in NRG mice; Fig. S7: CD73 and EMT correlations&lt;/p&gt;
Printing Ultrasensitive Artificially Intelligent Sensors Array with a Single Self-Propelled Droplet Containing Nanoparticles (2019)

<strong><em>This is the peer reviewed version of the following article: Homede, E., Abo-Jabal, M., Ionescu, R., &amp; Haick, H. (2016). Printing Ultrasensitive Artificially Intelligent Sensors Array with a Single Self</em></strong><strong><em>‐</em></strong><strong><em>Propelled Droplet Containing Nanoparticles. Advanced Functional Materials, 26(35), 6359-6370., which has been published in final form at </em></strong><strong><em>https://doi.org/10.1002/adfm.201602326</em></strong><strong><em>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.</em></strong>
<title>Diode laser testing by taking advantage of its photoelectric properties</title> (2002)

We report on the potential of the photocurrent technique as analytical tool for diode laser testing. The physics involved into the generation of photocurrents as well as experimental requirements for detecting them are highlighted. Based on a number of practical examples, we demonstrate how knowledge about the photoelectrical properties of diode lasers can help to learn about stress and defects within packaged devices or how non-perfect device fabrication may be discovered. These results are discussed in conjunction with device reliability issues.
High performance 2.4 GHz combined LTCC/SAW filter for WLAN applications in mobile phones (2007)

This paper presents a high performance filter for wireless LAN applications in mobile phones. Excellent out-of- band attenuation performance in combination with low insertion loss is achieved by a combination of a SAW filter with high attenuation close to passband with a simple low-loss LTCC filter. The achieved performance makes it possible to use such filter in highly-integrated WLAN front-end modules.
A comparative Studies of Physio Chemical Properties of Linen Yarn Dyed Fabric Dyed with Reactive & Vat Dye (2023)

This paper investigates the physio-chemical properties of yarn dyed linen fabric dyed with reactive &amp; vat dye. The mechanical &amp; chemical properties such as tear strength, tensile strength, seam strength, pilling, colour fastness to washing, perspiration and rubbing of those fabrics were investigated and compared with each other after making reactive &amp; vat yarn dyed linen fabric keeping same shade%, yarn count, epi, ppi&amp; gsm. It is claimed to bring many advantages of linen fabric quality for future. When the results were studied, it was observed that the mechanical properties like tear strength, tensile strength was found higher in yarn dyed vat linen fabric than yarn dyed reactive linen fabric&amp; in case of colour fastness to wash &amp; perspiration, yarn dyed vat linen fabric shows good colour fastness than yarn dyed reactive linen fabric &amp;yarn dyed reactive linen fabric gives better rubbing fastness than yarn dyed vat linen fabric.
Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors (2023)

Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors
Phase II trial of 177lutetium radiolabeled anti-PSMA antibody J591 (177Lu-J591) for metastatic castrate-resistant prostate cancer (metCRPC): Survival update and expansion cohort with biomarkers. (2013)

121 Background: A phase II trial in men with progressive metCRPC receiving a single dose of 177 Lu-J591 at 65 mCi/m 2 (15 pts) or 70 mCi/m 2 (phase I MTD, 17 pts) was performed without selection for PSMA expression, suggesting a larger than expected dose-response (13 vs 47% &gt;30% PSA decline respectively), leading to an expansion cohort to validate the response rate at 70 mCi/m 2 . Methods: Endpoints: to validate the PSA and/or measurable disease response at 70 mCi/m 2 , evaluate circulating tumor cell counts (CellSearch) and pre-treatment PSMA imaging with 111 In-J591 in the expansion cohort, and examine overall survival (OS) for all pts. Results: 15 additional pts were treated. Expansion cohort demographics were similar to the initial cohorts, and PSA responses and toxicity were similar to the initial cohort treated at 70 mCi/m 2 (see Table), with myelotoxicity improving in all following nadir at 1 month. More PSA declines and longer OS were seen at 70 mCi/m 2 . 12 of 15 pts had baseline and follow up CTC counts at 4-6 weeks: 66.7% had &gt;50% decline and 25% were unchanged at 0 or 1 (one declined 27%). Although 93.3% had accurate targeting (imaging) of known sites of disease, as seen in initial analysis, a trend for fewer &gt; 30% PSA declines was seen with less intense PSMA imaging. Conclusions: Single dose 177 Lu-J591 at70 mCi/m 2 was generally well tolerated, with predictable, reversible myelosuppression, and demonstrates anti-tumor activity in pts with progressive metCRPC. A dose-response relationship was confirmed for both toxicity and activity, with improved response and OS at 70 mCi/m 2 . CTC declines are demonstrated. Selection of pts based upon non-invasive testing (PSMA imaging) may improve the therapeutic profile. Clinical trial information: NCT00195039. [Table: see text]
Contribution à l'étude du système quinaire Ca++NH4+H+NO3−PO4− − −H2O. VI. Le diagramme de solubilité à quatre dimensions du phosphate monocalcique (1951)

Abstract 1º Dans le système quinaire le domaine de cristallisation du phosphate monocalcique a été étudié à la température de 25°. Nous communiquons la composition de 64 solutions dont le point figuratif est situé à l'intérieur du «solide de saturation» de ce sel.
Effect of contact properties on current transport in metal/molecule/GaAs devices (2006)

Previous reports on metal/molecule/semiconductor (MMS) devices have investigated the effects of molecular species, including dipoles, but have not considered the semiconductor contact properties in detail. In this paper we report on a study of the effects of variations in the semiconductor contact on the conduction properties of MMS devices. Metal/molecule/gallium arsenide (GaAs) devices were fabricated using various semiconductor contact layers, electrically characterized versus temperature and analyzed using an electrostatic model. The various semiconductor contacts included heavily doped n-type and p-type GaAs layers, as well as n-doped and p-doped surface layers of low-temperature-grown GaAs (LTG:GaAs), which provide a high density of midgap defect states near the semiconductor surface. The impact of changing the work function of the top metal contact has also been studied. An electrostatic model that incorporates information on the molecular dipole moment, defect states in GaAs surface layers, and the work function of the metal contact, has been developed in order to understand the band diagrams corresponding to the various device types, and to explain the current-voltage behavior observed in the devices. It is shown by controlling the properties of the semiconductor contact that the device characteristics can be tuned from being dominated by the GaAs barrier (heavily doped n-type GaAs) to being dominated by the molecular states that are strongly coupled to the GaAs contact (LTG:GaAs and heavily doped p-type GaAs).