gebhart/patrepeval huggingface dataset:
Lower extremity reconstruction (2006)

The current recommendation for surgical treatment of tumors of the lower extremity is a limb-sparing resection. Limb-sparing resection coupled with complex reconstructive techniques and complemented by new chemotherapeutic agents and adjuvant radiation therapy has allowed us to achieve survival rates that are comparable to those of amputation with a better functional outcome. Recent advances in microsurgical techniques and the associated technologies and a better understanding of microvascular anatomy has allowed us to customize flaps to the specific needs of the patients and to achieve a lower donor site morbidity. Increased communication between the specialties of the multidisciplinary treatment team has also improved outcomes. The reconstructive component has become an integral part of the multidisciplinary care for patients with lower extremity tumors. It not only allows them to rapidly resume adjuvant therapies but also enables them to more easily resume their activities of daily living.
Structure-from-Motion using Dense CNN Features with Keypoint Relocalization (2018)

Structure from Motion (SfM) using imagery that involves extreme appearance changes is yet a challenging task due to a loss of feature repeatability. Using feature correspondences obtained by matching densely extracted convolutional neural network (CNN) features significantly improves the SfM reconstruction capability. However, the reconstruction accuracy is limited by the spatial resolution of the extracted CNN features which is not even pixel-level accuracy in the existing approach. Providing dense feature matches with precise keypoint positions is not trivial because of memory limitation and computational burden of dense features. To achieve accurate SfM reconstruction with highly repeatable dense features, we propose an SfM pipeline that uses dense CNN features with relocalization of keypoint position that can efficiently and accurately provide pixel-level feature correspondences. Then, we demonstrate on the Aachen Day-Night dataset that the proposed SfM using dense CNN features with the keypoint relocalization outperforms a state-of-the-art SfM (COLMAP using RootSIFT) by a large margin.
COMMENTARY (2009)

COMMENTARY Cellulite is considered a secondary female characteristic1 and has even been demonstrated upon pinching a 6-month-old, female infant's thigh2 … therefore it is reasonable to believe that a significant challenge awaits those seeking to cure this “disease.” Hexsel et al3 should be commended for designing a unique, blinded investigation aimed at visualizing and quantifying the oft cited “fibrous septae” responsible for the pathognomonic peau d'orange appearance of cellulite. They demonstrate convincingly that a relatively thick (>2 mm) vascular and/or lymphatic fibrous tissue network permeates within the subcutaneous tissue underlying skin exhibiting cellulite. In order to be effective, therapeutic approaches for cellulite will have to disrupt these septae. It is unlikely that currently available injectable and superficial energy based devices4 will have a profound effect on these septae, effacing the skin dimpling bothersome to many patients. As this study and the work of others5 reveal, the architecture of fat and cellulite is complex. Despite its expense, MRI should be integrated into controlled studies of treatments intended to reduce the appearance cellulite, just as Goldberg and colleagues recently presented.6 Perhaps broader appreciation of anatomy and refining photography and other outcome measures in clinical studies will eventually lead to sophisticated methods that alleviate this benign but aesthetically bothersome condition. ADAM M. ROTUNDA MD *Newport Beach, CA
Table S9 from Transient Depletion of CD4<sup>+</sup> Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer (2023)

&lt;p&gt;Supplementary Table 9&lt;/p&gt;
Lassa hemorrhagic fever in a late term pregnancy from northern sierra leone with a positive maternal outcome: case report (2011)

Lassa fever (LF) is a devastating viral disease prevalent in West Africa. Efforts to take on this public health crisis have been hindered by lack of infrastructure and rapid field deployable diagnosis in areas where the disease is prevalent. Recent capacity building at the Kenema Government Hospital Lassa Fever Ward (KGH LFW) in Sierra Leone has lead to a major turning point in the diagnosis, treatment and study of LF. Herein we present the first comprehensive rapid diagnosis and real time characterization of an acute hemorrhagic LF case at KGH LFW. This case report focuses on a third trimester pregnant Sierra Leonean woman from the historically non-endemic Northern district of Tonkolili who survived the illness despite fetal demise. Employed in this study were newly developed recombinant LASV Antigen Rapid Test cassettes and dipstick lateral flow immunoassays (LFI) that enabled the diagnosis of LF within twenty minutes of sample collection. Deregulation of overall homeostasis, significant hepatic and renal system involvement, and immunity profiles were extensively characterized during the course of hospitalization. Rapid diagnosis, prompt treatment with a full course of intravenous (IV) ribavirin, IV fluids management, and real time monitoring of clinical parameters resulted in a positive maternal outcome despite admission to the LFW seven days post onset of symptoms, fetal demise, and a natural still birth delivery. These studies solidify the growing rapid diagnostic, treatment, and surveillance capabilities at the KGH LF Laboratory, and the potential to significantly improve the current high mortality rate caused by LF. As a result of the growing capacity, we were also able to isolate Lassa virus (LASV) RNA from the patient and perform Sanger sequencing where we found significant genetic divergence from commonly circulating Sierra Leonean strains, showing potential for the discovery of a newly emerged LASV strain with expanded geographic distribution. Furthermore, recent emergence of LF cases in Northern Sierra Leone highlights the need for superior diagnostics to aid in the monitoring of LASV strain divergence with potentially increased geographic expansion.
Basis set and electron correlation effects on the total electron density in water, hydrogen sulfide, and borane(1) (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBasis set and electron correlation effects on the total electron density in water, hydrogen sulfide, and borane(1)Jozef Bicerano, Dennis S. Marynick, and William N. LipscombCite this: J. Am. Chem. Soc. 1978, 100, 3, 732–739Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ja00471a011https://doi.org/10.1021/ja00471a011research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Colony‐stimulating factor enhancement of myeloid effector cell cytotoxicity towards neuroectodermal tumour cells (1993)

We conducted experiments to determine the optimal conditions for colony-stimulating factor-enhanced neutrophil- and mononuclear phagocyte-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) using monoclonal antibodies to disialogangliosides expressed on neuroectodermal tumour target cells. Neutrophil ADCC was most effective at effector:target ratios of 100:1, with maximal cytotoxic responses to melanoma target cells generated by 3 h. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) were the most potent stimulators of neutrophil ADCC, and enhanced ADCC activity was inhibited in the presence of antibody to Fc receptor type II (FcRII). GM-CSF and macrophage colony-stimulating factor (M-CSF) treatment of freshly isolated monocytes inhibited antibody-independent cytotoxicity but enhanced antibody-dependent responses. After 3 d in culture with CSF, 3-10-fold enhancement of ADCC against melanoma target cells was observed at effector:target cell ratios of 10:1. Greatest stimulation of macrophage ADCC was obtained when GM-CSF, M-CSF or interleukin 3 (IL-3) were used in conjunction with a secondary stimulus. Although gamma interferon (gamma-IFN) did not augment the cytotoxic capability of GM-CSF- and IL-3-stimulated macrophages, prominent cytotoxic enhancement was seen when M-CSF-stimulated macrophages were exposed to gamma-IFN. A chimaeric mouse/human monoclonal antibody was found to be equivalent in activity to the murine antibody in neutrophil ADCC; however, in macrophage ADCC assays with submaximal effector cell stimulation, the chimaeric antibody was associated with a two-fold greater response. These studies indicate that under specific conditions, CSFs capable of increasing the number and functional activity of mature myeloid effector cells enhance antibody-dependent cytotoxicity to neuroectodermal tumour target cells.
BLOCKADE OF MULTIPLE COSTIMULATORY RECEPTORS INDUCES HYPORESPONSIVENESS (1996)

T-lymphocyte activation requires engagement of the T cell receptor with antigen-major histocompatibility complex, and simultaneous ligation of costimulatory pathways via the lymphocyte receptors CD2 and CD28/ CTLA4. Anti-CD2 monoclonal antibody (mAb) blocks the interaction of the antigen-presenting cell receptor CD48 with its ligand CD2, whereas CTLA4Ig binds with high affinity to the antigen-presenting cell ligands B7-1 and B7-2, blocking their interaction with CD28/CTLA4. We tested the immunosuppressive effects of simultaneously blocking both costimulatory pathways. Using donor C57BL/6J (H2b) hearts transplanted to CBA/J (H2k) recipients, anti-CD2 mAb plus CTLA4Ig administered at the time of transplantation prolonged cardiac allograft mean survival time to >120 days compared with untreated controls (12.2+/-0.5 days, P<0.01), anti-CD2 mAb alone (24.8+/-1.0 days, P<0.01), or CTLA4Ig alone (55.0+/-2.0 days, P<0.01). Retransplantation of these recipients with donor-specific and third-party grafts demonstrated that hyporesponsiveness and tolerance were achieved. In vitro stimulation of lymphocytes from tolerant recipients with donor-specific alloantigen resulted in normal cytotoxic T lymphocyte and mixed lymphocyte reaction responses, showing that clonal deletion or anergy did not occur, but that graft adaptation or suppression likely helped to maintain long-term graft survival. In vitro combinations of anti-CD2 mAb and CTLA4Ig suppressed the generation of allogeneic cytotoxic T lymphocytes (58%) and the mixed lymphocyte reaction (36%); CTLA4Ig was more effective in this regard and the two agents were not synergistic. Anti-CD2 mAb and CTLA4Ig suppressed mitogen-driven proliferation in differential fashions, suggesting that they affected independent signaling pathways. Anti-CD2 mAb and CTLA4Ig also inhibited interleukin (IL)-2, IL-4, and IL-2 receptor (CD25). These data indicate that anti-CD2 mAb plus CTLA4Ig induces hyporesponsiveness and tolerance. The mechanism is likely related to the initial disruption of independent pathways of T-lymphocyte activation leading to antigen-specific long-term graft survival.
A Laboratory EXAFS Study with Higher-Order Bragg Reflection by Means of the Fluorescence Monitoring Technique (1993)

A Laboratory EXAFS study has been tested by using higher-order Bragg reflections of Ge(440), Ge(333) and Ge(444). A single crystal spectrometer was employed and the incident x-ray intensity was monitored by measuring the fluorescent radiation from a suitable material placed in front of a sample. Good EXAFS spectra were obtained for relatively heavy elements of Se, Y and Zr with this technique. In addition, high intensity photon fluxes have been obtained, which are 6 and 3 times stronger than the case of double-crystal spectrometer at photon energies of 12 and 16 keV, respectively.
Bimodal MR–PET Agent for Quantitative pH Imaging (2010)

Zwei Unbekannte: Die Relaxivität aktivierbarer Magnetresonanz(MR)-Kontrastmittel wird durch Faktoren wie pH-Wert oder Enzymaktivität beeinflusst, doch das MR-Signal hängt von der Relaxivität und der Kontrastmittelkonzentration ab. Simultane Positronenemissionstomographie (PET) und MR-Bildgebung (MRI) mit dem gezeigten bimodalen pH-empfindlichen MR-PET-Agens ermöglicht es, die Konzentration und T1, und somit den pH-Wert, direkt zu bestimmen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Modeling the Nonlinearities in Horn Loudspeakers (1996)

Nonlinearities in horn loudspeakers are modeled by electromechanical-acoustical analogous circuits with lumped parameters as well as by block-oriented systems composed of linear dynamic subsystems and nonlinear static subsystems. The nonlinear parameters are developed by a power series expansion, and the second- and third-order system functions based on a Volterra series approach are presented. These higher order system functions allow a quantitative prediction of the harmonic and intermodulation distortion in the radiated sound pressure signal and show in principle the characteristic steady-state response of the nonlinear distortion for each nonlinearity. This information is helpful for interpreting the results of nonlinear distortion measurements and determining the dominant nonlinearities in horn loudspeakers. The structure of the derived system models is valuable a priori information for performing system identification to verify the modeling and to determine relevant loudspeaker parameters.
SPIDER: An availability‐aware framework for the service function chain placement in distributed scenarios (2022)

Abstract The network function virtualization (NFV) paradigm replaces hardware‐dependent network functions by virtual network functions (VNFs) that can be deployed in commodity hardware, including legacy servers. Consequently, the use of NFV is expected to reduce operating and capital expenses, as well as improve service deployment operation and management flexibility. For many use cases, the VNFs must be visited and invoked following a specific order of execution in order to compose a complete network service, named service function chain (SFC). Nonetheless, despite the benefits from NFV and SFC virtualization technologies, their introduction must not harm network performance and service availability. On the one hand, redundancy is seen by network service planners as a mechanism well established to combat availability issues. At same time, there is a goal to optimize resource utilization in order to reduce operational expenditure. In this article, we share our experience in the design use of a framework, named SPIDER, focused on SFC placement that considers the network infrastructure condition and the required SFC availability to define the placement strategy. The SPIDER monitors the status of infrastructure nodes and links and defines which servers the VNFs should be placed on and the number of redundant replicas needed. We present a proof‐of‐concept of SPIDER using Kubernetes to launch the VNFs as containers. We also use Kubernetes to forward the traffic between the VNFs, composing the service chain. We perform experiments to evaluate the runtime of SPIDER and the SFC delay under different network conditions.
Improved voltage margins using linear error-correcting codes in resistor-logic demultiplexers for nanoelectronics (2005)

We present a family of demultiplexer circuit designs based on linear error-correcting codes, which can be laid out on nanoelectronic crossbar structures. The crossbars are assumed to have configurable resistors at the crosspoint junctions, and the demultiplexer circuits are therefore implemented using resistor logic. In general, resistor logic offers poor voltage margins when implementing digital circuits, but the circuit construction we present allows us to circumvent this problem by capitalizing on the minimum-distance property of codes to avoid certain problem cases, and thus achieve a much larger voltage margin. For each linear code, there is a corresponding demultiplexer circuit prescribed by this construction, and thus a large family of demultiplexer circuits is defined. When a demultiplexer of a given size is needed in a system, this circuit family offers to the designer a set of alternative demultiplexer circuit designs, in which increasing voltage margins can be achieved, but at the cost of increasing circuit area. We analyse a demultiplexer circuit based on an arbitrary linear code. For this general case, we give the encoding computation prescribed by the code, give the configuration pattern prescribed by the code for the crossbar part of the circuit, calculate the output voltage on each of the demux output lines as a function of the current input signal, calculate the worst-case voltage margin, and calculate cost parameters measuring the increased area consumed by the circuit. This code-based demultiplexer circuit design makes it possible to handle the voltage-margin problem of resistor logic, and thus makes it feasible to build relatively large demultiplexers using nano-scale crossbars with configurable resistors at the crossbar junctions.
Detection and Identification of Buried Explosive Hazards Using High Frequency EMI Sensing (2018)

This paper demonstrates applicability of the HFEMI for detection and classification of subsurface explosive hazards. There are three categories of explosive hazards: metallic, intermediate electrically conducting (IEC), and nonconducting targets. Metallic target detection and classification by electromagnetic induction sensing has been the subject of research for many years. Key to the success of this research is modern multi-static Electromagnetic Induction (EMI) sensors, which are able to measure the wideband EMI response from metallic buried targets. However, until now no hardware solutions existed for reliably detecting and characterizing IEC, low metal content and non-conducting targets. While high-conducting metallic targets exhibit a relaxation peak for frequencies in the traditional EMI regime (less than 100 kHz), the response of IEC and low metal-content objects manifests itself at higher frequencies, in the high-frequency EMI (HFEMI) band between 100 kHz and 15 MHz, which spans the transition between the induction and radar bands.
Autophagic degradation of GZMB/granzyme B (2013)

The crucial issue for defining successful natural killer (NK)-based anticancer therapy is the ability of tumor cells to activate resistance mechanisms leading to escape from NK-mediated killing. It is now well established that such mechanisms are likely evolved under hypoxia in the tumor microenvironment. Here, we show that hypoxia-induced autophagy impairs breast cancer cell susceptibility to NK-mediated lysis and that this impairment is reverted by targeting autophagy. We provide evidence that activation of autophagy in hypoxic cells is involved in selective degradation of the pro-apoptotic NK-derived serine protease GZMB/granzyme B, thereby blocking NK-mediated target cell apoptosis. Our in vivo data validate the concept that targeting autophagy in cancer cells promotes tumor regression by facilitating their elimination by NK cells. This study provides a cutting-edge advance in our understanding of how hypoxia-induced autophagy impairs NK-mediated lysis and might pave the way for formulating more effective NK-based antitumor therapy by combining autophagy inhibitors.
<title>Patterning of highly conducting polyaniline films</title> (2000)

Polyaniline is a family of soluble, electrically conducting polymers that have a potential for a number of applications. They are a unique class of electronic materials which combines the electronic properties of metals with the mechanical and physical properties, and the processing advantages of a conventional organic polymer. In this paper, we will discuss the synthesis, and formulation of a highly conductive polyaniline that has applications as electrodes or thin film wiring. However, for these and other uses it is necessary to pattern the conducting polymer lithographically. We will discuss the various ways of patterning polyaniline, either indirectly or using the conventional photoresist technology. The effects of each patterning procedure on the conductivity of the polyaniline will also be covered.
Design and analysis of an optimal instruction-retry policy for TMR controller computers (1996)

An instruction-retry policy is proposed to enhance the fault-tolerance of triple modular redundant (TMR) controller computers by adding time redundancy to them. A TMR failure is said to occur if a TMR system fails to establish a majority among its modules' outputs due to multiple faulty modules or a faulty voter. Either multiple consecutive TMR failures the active period of which exceeds a certain time limit or the exhaustion of spares as a result of frequent system reconfigurations may result in failure to meet the timing constraints of one or more tasks, called the dynamic failure, during a given mission. An optimal instruction-retry period is derived by minimizing the probability of dynamic failure upon detection of either a masked (by the TMR) error or a TMR failure. We also derive the minimum number of spares needed to keep below the pre-specified level the probability of dynamic failure for a given mission by using the derived optimal retry period.
The Nerve Growth Factor Receptor CD271 Is Crucial to Maintain Tumorigenicity and Stem-Like Properties of Melanoma Cells (2014)

Our present study provides a deeper insight into the regulation of melanoma cell properties and points CD271 out as a regulator of several melanoma-associated genes. Further, our data strongly suggest that CD271 is a crucial determinant of stem-like properties of melanoma cells like colony-formation and tumorigenicity.
Guided SH-SAW characterization of elasticity variations of mesoporous TiO2 Sensitive Films during Humidity Sorption (2010)

International audience
Channel estimation in narrowband wireless communication systems (2001)

Abstract Channel estimation is an integral part of standard adaptive receiver designs used in narrowband, digital wireless communication systems. In this tutorial paper, commonly used approaches to channel estimation are reviewed. Both time‐invariant and time‐varying channels are considered. For time‐varying channels, both pilot symbol interpolation and data‐directed channel tracking are considered. Applications include the Global System for Mobile communications, the Enhanced Data rates for Global Evolution system, and another Time‐Division Multiple‐Access system known as Telecommunications Industry Association/Electronics Industry Association/Interim Standard—136 (TIA/EIA/IS‐136 or IS‐136). Copyright © 2001 John Wiley &amp; Sons, Ltd.