gebhart/patrepeval huggingface dataset:
Exploring Interactive Sound Design for Auditory Websites (2022)

Auditory interfaces increasingly support access to website content, through recent advances in voice interaction. Typically, however, these interfaces provide only limited audio styling, collapsing rich visual design into a static audio output style with a single synthesized voice. To explore the potential for more aesthetic and intuitive sound design for websites, we prompted 14 professional sound designers to create auditory website mockups and interviewed them about their designs and rationale. Our fndings reveal their prioritized design considerations (aesthetics and emotion, user engagement, audio clarity, information dynamics, and interactivity), specifc sound design ideas to support each consideration (e.g., replacing spoken labels with short, memorable audio expressions), and challenges with applying sound design practices to auditory websites. These fndings provide promising direction for how to support designers in creating richer auditory website experiences.
A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study (2017)

NCT02095548.
Changes in hematopoiesis-supporting ability of C3H10T1/2 mouse embryo fibroblasts during differentiation (1993)

To investigate the functional change of stromal cells along with differentiation, we used a differentiation-inducible mouse embryo fibroblast cell line, C3H10T1/2 (10T1/2). Stably determined preadipocyte and myoblast cell lines were established after a brief exposure of 10T1/2 cells to 5-azacytidine. These cell lines terminally differentiated into adipocytes and myotubes, respectively, under appropriate conditions. The hematopoiesis-supporting ability of each 10T1/2-derived cell line was examined by coculture with FACS-sorted murine hematopoietic stem cells (Thy-1lo c-kit+ Lin-). The number of granulocyte-macrophage progenitors (CFU-GM) was slightly reduced after 7 days of culture with parent 10T1/2 fibroblasts, whereas a marked increase in CFU-GM number was observed when the cells were cultured on preadipocytes. Mature adipocytes and myogenically determined cell lines, on the other hand, did not support CFU-GM growth. Further, Northern analysis showed that the preadipocyte cell line acquired the ability to produce a significant amount of stem cell factor (SCF), interleukin-6 (IL-6), leukemia inhibitory factor, and macrophage colony- stimulating factor mRNAs in response to IL-1 or lipopolysaccharide stimulation. Terminal adipocytic differentiation resulted in reduced ability to express these cytokine mRNAs. Similarly, highest IL-6 activity was detected in the supernatant of preadipocyte culture, whereas adipocytes did not secrete IL-6 even after IL-1 stimulation. Interestingly, hematopoiesis-nonsupporting myoblasts and myotubes also expressed abundant SCF mRNA, suggesting that SCF, per se, may not be sufficient for stem cell growth and survival. The 10T1/2-derived cell lines could provide a valuable tool to aid in the analysis of stromal cell development and the search for novel stromal factors.
RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits (2016)

Alzheimer's disease (AD) is the most common form of dementia in the elderly. It is generally believed that β-amyloidogenesis, tau-hyperphosphorylation, and synaptic loss underlie cognitive decline in AD. Rps23rg1, a functional retroposed mouse gene, has been shown to reduce Alzheimer's β-amyloid (Aβ) production and tau phosphorylation. In this study, we have identified its human homolog, and demonstrated that RPS23RG1 regulates synaptic plasticity, thus counteracting Aβ oligomer (oAβ)-induced cognitive deficits in mice. The level of RPS23RG1 mRNA is significantly lower in the brains of AD compared to non-AD patients, suggesting its potential role in the pathogenesis of the disease. Similar to its mouse counterpart, human RPS23RG1 interacts with adenylate cyclase, activating PKA/CREB, and inhibiting GSK-3. Furthermore, we show that human RPS23RG1 promotes synaptic plasticity and offsets oAβ-induced synaptic loss in a PKA-dependent manner in cultured primary neurons. Overexpression of Rps23rg1 in transgenic mice consistently prevented oAβ-induced PKA inactivation, synaptic deficits, suppression of long-term potentiation, and cognitive impairment as compared to wild type littermates. Our study demonstrates that RPS23RG1 may reduce the occurrence of key elements of AD pathology and enhance synaptic functions to counteract oAβ-induced synaptic and cognitive deficits in AD.
Measurement of Impulsive Distortion, Rub and Buzz and other Disturbances (2003)

The traditional distortion measurement transforms the time signal into the frequency domain to separate fundamental, harmonic and intermodulation components. This technique considers only the mean power in the analyzed interval and neglects the phase information. A new technique for the measurement of the signal distortion in time domain is presented that exploits both amplitude and phase information. It reveals the fine structure of the distortion and its dependency on frequency, displacement or other state variables. Besides the rms-value of the distortion the peak value and the crest factor are important characteristics for detection of rub and buzz phenomena. The practical application, the interpretation and the diagnostics of defects are discussed.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF A NOVEL FAMILY OF DIMERIC NICKEL(II) COMPLEXES ‐ BIMETALLIC SPECIES SEPARATED BY A PERSISTENT VOID (1981)

Abstract Bimetallic Species Separated by a Persistent Void.
Erratum to: Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis (2021)

In the article “Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis,” an author was missing. Ana Maseda should be listed as the 11th author. The correct author list is: Benjamin Kye Jyn Tan, Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Eva K Fenwick, Varshini Varadaraj, Bonnielin K Swenor, Preeti Gupta, Tien Yin Wong, Caterina Trevisan, Laura Lorenzo-López, Ana Maseda, José Carlos Millán-Calenti, Carla Helena Augustin Schwanke, Ann Liljas, Soham Al Snih, Yasuharu Tokuda, Ecosse Luc Lamoureux. This error has been corrected.
X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, .delta. Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, .delta. Opioid Receptor-Selective Compound: Comparisons with Proposed Solution ConformationsJudith L. Flippen-Anderson, Victor J. Hruby, Nathan Collins, Clifford George, and Bob CudneyCite this: J. Am. Chem. Soc. 1994, 116, 17, 7523–7531Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00096a008https://doi.org/10.1021/ja00096a008research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Alkyl‐Functionalized Oxide‐Free Silicon Nanoparticles: Synthesis and Optical Properties (2009)

Due to the presence of trace amounts of toluene remaining from the synthesis, the optical absorption and emission properties of the alkyl-terminated silicon nanoparticles (Si NPs) at wavelengths <270 nm reflect the presence of both toluene and Si NPs. Unambiguous spectroscopic data can be obtained at wavelengths ≥280 nm, as at these wavelengths remaining traces of toluene do not display any absorption.1 The extinction coefficient ε of these Si NPs at 280 nm is 9.4 × 103 M−1 cm−1.2 Unfortunately, the vibrational progressions (Figure 5 of the original paper, bottom graph) and scattering data mentioned on p. 1839 are largely determined by this presence of toluene. The second and third columns of Table 1 should be corrected as shown below. (The quantum yields and lifetimes, columns 4–6, remain unchanged.) Figure 5 of the original paper should be replaced by Figure 5 (right), which shows the toluene-free optical absorption and fluorescence of these nanoparticles. Absorption (black line) and emission (red line; λ = 280 nm) spectra of SiC16H33 (5 × 10−5 M) in hexane. The authors would like to thank Loes Ruizendaal (Wageningen University), Ramunas Augulis, and Prof. Paul van Loosdrecht (University of Groningen) for bringing this to our attention, and Prof. M. A. Lopez-Quintela, Dr. X. Duan (University of Santiago de Compostela), and Javier Calvo-Fuentes (NANOGAP, A Coruña) for independently discovering and verifying this in detail.
On-chip Test and Repair of Memories for Static and Dynamic Faults (2006)

In addition to static faults, dynamic faults are increasingly important for high density embedded memories due to aggressive design rules and shrinking feature sizes. Not only is the test of these faults important, their repair is important too for devices where the yield loss due to memory fails is significant. Dynamic faults can impact one or more memory cells. In the case of the latter, it is also important to diagnose the cell causing the fault, and hence to be repaired. This paper describes an on-chip test and repair solution for static and dynamic faults in random access memories. The main contributions of this paper are three fold: (i) development of new algorithms for detection of static and dynamic faults, and for identification of faulty aggressor cells, (ii) extension of fault syndromes for diagnosis and location of aggressor cells, and (iii) development of an on-chip test, analysis and repair solution implementing these algorithms. It is shown how the proposed fault detection algorithms and redundancy analysis schemes are superior to existing ones for analysis time, hardware overhead, fault coverage and aggressor location capability
The molecular and pathway characterization of patients with metastatic castration resistant prostate cancer (mCRPC) refractory to therapy with abiraterone acetate or enzalutamide: Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). (2014)

79 Background: Progressive metastatic castration resistant prostate cancer (mCRPC) has historically been challenging to biopsy and characterize on a molecular basis because of its bone tropism. Since mechanisms of resistance to androgen signaling inhibitors such as enzalutamide or abiraterone are not fully understood, both an unbiased and a targeted assessment of the molecular landscape of these patients is required. Methods: Patients (pts) with mCRPC undergo biopsy at one of five West Coast Prostate Cancer Dream Team (WCDT) clinical sites, using a uniform biopsy protocol, following central radiologic review. Tissue is both frozen, and formalin fixed/paraffin embedded (FFPE). Frozen tissue undergoes laser capture microdissection (LCM) for RNA seq, DNA seq, and array comparative genomic hybridization (aCGH). An RNA seq process was developed that allows using extremely small quantities of RNA (approximately 1 ng). FFPE tissue undergoes a CLIA-certified assessment of a 37-gene mutational panel, FISH for AR, and IHC for PTEN. Peripheral blood is collected for miRNA, immune responses, and CTC analysis including aCGH. Pathway assessment integrating clinical, RNA seq, DNA seq, aCGH data is undertaken using PARADIGM analysis. Results: Thirty six of 300 planned mCRPC pts have undergone a metastasis biopsy: 17 from bone, eight from liver, one from lung, and 10 from distant lymph nodes. Tumor is present in around 75% of the frozen specimens. To date, LCM has been undertaken in 11 samples, with RNA seq done in six, DNA whole exome seq in one, aCGH in four. FFPE tissue has been evaluated by mutational panel sequencing (n=9), FISH for AR (n=11), and IHC for PTEN (n=13). CTC have been isolated in 33 pts. aCGH has been successfully undertaken in paired CTC and biopsy specimens. Expression data from patients with full RNA sequencing have been analyzed by PARADIGM, with top disrupted pathways identified. Conclusions: Biopsies of mCRPC, including from bony sites, can be undertaken and used for molecular and pathway analysis. Sufficient tissue for unbiased and targeted assessment can be obtained. Linkage of results from these studies to the clinical characteristics of these patients will reveal important insights into mechanisms of resistance.
Implications of 3-D integrated circuits at board test position paper (2009)

Three-dimensional integrated circuits are coming to circuit boards near you. Testing boards with such components offers new, yet familiar challenges. As before, we need to determine if the right device is present, oriented, live, properly aligned and attached to the board with no shorts, opens or attachment quality defects.
The BIG 2.04 MRC/EORTC SUPREMO Trial: pathology quality assurance of a large phase 3 randomised international clinical trial of postmastectomy radiotherapy in intermediate-risk breast cancer (2017)

These data have important implications for the design, powering and interpretation of outcomes from this and future clinical trials. If critical pathology criteria are determinants for trial entry, serious consideration should be given to up-front central pathology review.
Striped ratio grids for scatter estimation (2016)

Striped ratio grids are a new concept for scatter management in cone-beam CT. These grids are a modification of conventional anti-scatter grids and consist of stripes which alternate between high grid ratio and low grid ratio. Such a grid is related to existing hardware concepts for scatter estimation such as blocker-based methods or primary modulation, but rather than modulating the primary, the striped ratio grid modulates the scatter. The transitions between adjacent stripes can be used to estimate and subtract the remaining scatter. However, these transitions could be contaminated by variation in the primary radiation. We describe a simple nonlinear image processing algorithm to estimate scatter, and proceed to validate the striped ratio grid on experimental data of a pelvic phantom. The striped ratio grid is emulated by combining data from two scans with different grids. Preliminary results are encouraging and show a significant reduction of scatter artifact.
Classification of simulated elastograms based on texture features (2002)

Elastography is a new imaging modality which provides an image of tissue elastic properties. Simulated elastograms are used to study the ability of textural features to discriminate between abnormalities with different levels of hardness and density. Elastograms are simulated for different signal processing parameters as well as for a non-uniform stress field. 15 selected texture features are extracted. The Gaussian classifier does not perform well due to the complexity of clusters. Hence, a neural network classifier is trained and tested to discriminate between the classes. The results indicate that the texture features perform well under variations of the signal processing parameters and non-uniformity of the applied stress field. This simulation study provides a guiding mechanism to discriminate between malignant and benign tissue abnormalities once clinical data becomes available.
The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA (2015)

Antisense oligonucleotides (ASOs) are most commonly designed to reduce targeted RNA via RNase H1-dependent degradation, however kinetic parameters for ASO-mediated targeting and subsequent cleavage and degradation of RNA in living cells are poorly understood. In this manuscript we use an inducible minigene system to determine the time course of ASO activity in the cell. Estimates of the time required for the ASO to enter and traverse the cell, scan the target mRNA, bind the cognate site, recruit RNase H1 and initiate cleavage, are presented in the context of transcription and mRNA processing rates. Data are also presented which indicate that rates for RNase H1-dependent ASO-mediated degradation of the targeted RNAs are different for nuclear-retained versus RNAs exported to the cytoplasm and that the level of RNase H1 in the cell and cellular compartments is limiting to the rate of ASO activity. In both cellular compartments RNase H1 ASOs essentially double the endogenous rates of clearance of the target RNA. Overexpression of Escherichia coli RNase H1 or the presence of multiple cognate sites each further increase the rate of target RNA degradation.
Effect of Volatile Components of Carrot Seed Oil on Growth and Aflatoxin Production by Aspergillus parasiticus (1983)

ABSTRACT The effect of the volatile fraction of carrot seed oil (VCSO) and its components on the growth and aflatoxin production by Aspergillus parasiticus was studied. Geraniol, citral and terpineol prevented growth and therefore aflatoxin production. VCSO inhibited growth and no aflatoxin was produced. Limonene and terpinene did not affect growth but inhibited aflatoxin production. The addition of VCSO, limonene and terpinene decreased the rate of primary metabolism as demonstrated by the higher final pH of the medium. VCSO, limonene and terpinene reduced the growth rate, measured by the incorporation of [ 3 H] amino acids into trichloracetic acid (TCA) insoluble protein. The addition of VCSO at anytime up to 5 days reduced the aflatoxin accumulation at 7 days.
META: Middleware for Events, Transactions, and Analytics (2016)

Businesses that receive events in the form of messages and react to them quickly can take advantage of opportunities and avoid risks as they occur. Since quick reactions are important, event processing middleware is a core technology in many businesses. However, the need to act quickly must be balanced against the need to act profitably, and the best action often depends on more context than just the latest event. Unfortunately, the context is often too large to analyze in the time allotted to processing an event. Instead, out-of-band analytics can train an analytical model, against which an event can be quickly scored. We built middleware that combines transactional event processing with analytics, using a data store to bridge between the two. Since the integration happens in the middleware, solution developers need not integrate technologies for events and analytics by hand. At the surface, our Middleware for Events, Transactions, and Analytics (META) offers a unified rule-based programming model. Internally, META uses the X10 distributed programming language. A core technical challenge involved ensuring that the solutions are highly available on unreliable commodity hardware, and continuously available through updates. This paper describes the programming model of META, its architecture, and its distributed runtime system.
Are There Generalizable Trends in the Release of Airborne Synthetic Clay Nanoparticles from a Jet Milling Process? (2014)

Despite recent efforts to assess the release of nanoparticles to the workplace during different nanotechnology activities, the existence of a generalizable trend in the particle release has yet to be identified. This study aimed to characterize the release of synthetic clay nanoparticles from a laboratory-based jet milling process by quantifying the variations arising from primary particle size and surface treatment of the material used, as well as the feed rate of the machine. A broad range of materials were used in this study, and the emitted particles mass (PM2.5) and number concentrations (PNC) were measured at the release source. Analysis of variance, followed by linear mixed-effects modeling, was applied to quantify the variations in PM2.5 and PNC of the released particles caused by the abovementioned factors. The results confirmed that using materials of different primary sizes and surface treatment affects the release of the particles from the same process by causing statistically-significant variations in PM2.5 and PNC. The interaction of these two factors should also be taken into account as it resulted in variations in the measured particles release properties. Furthermore, the feed rate of the milling machine was confirmed to be another influencing parameter. Although this research does not identify a specific pattern in the release of synthetic clay nanoparticles from the jet milling process this is generalizable to other similar settings, it emphasizes that each tested case should be handled individually in terms of exposure considerations.
Role of AT1‐receptors in hypercholesterolemia‐induced thrombosis. (2009)

Hypercholesterolemia is associated with increased platelet aggregation and increased risk for thrombosis. Previous reports have described the ability of diet‐induced hypercholesterolemia (HC) to enhance thromboembolism in arterioles, but not venules, in rabbit mesentery (Broeders; ATBV 22:680, 2002). The objectives of this study were to determine whether: 1) HC promotes thrombus formation in microvessels of mouse cremaster muscle and 2) angiotensin II type‐1 receptors (AT1‐R) mediate the HC‐induced responses. Intravital videomicroscopy was used to monitor thrombus formation induced with a light/dye endothelial injury model in mice placed on either a normal diet (ND), 2 wks high‐cholesterol diet (HCD) or HCD mice treated with the AT1‐R antagonist, losartan (25mg/kg/day) in drinking water for 7 days. Arterioles in HCD mice exhibited an enhanced rate of thrombus formation compared to ND mice, decreasing the time of thrombus onset and the time to flow cessation. As previously reported, light/dye‐induced thrombosis was not altered in venules of HCD mice. The HCD‐enhanced thrombosis in arterioles was not altered by losartan treatment. These findings confirm the vulnerability of arterioles to HC‐induced thrombosis, and indicate that mechanisms other than AT1‐R activation underlie the increased risk for thrombosis during hypercholesterolemia. (Supported by HL26441).
Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor‐Dependent Mechanism (2020)

These studies provide evidence that forebrain GABAergic neuron development and zebrafish risk-taking behavior are sensitive to both EtOH and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of EtOH and cannabinoids in FASD.