gebhart/patrepeval huggingface dataset:
Minimizing the Age of Incorrect Information for Real-time Tracking of\n Markov Remote Sources (2021)

The age of Incorrect Information (AoII) has been introduced recently to\naddress the shortcomings of the standard Age of information metric (AoI) in\nreal-time monitoring applications. In this paper, we consider the problem of\nmonitoring the states of remote sources that evolve according to a Markovian\nProcess. A central scheduler selects at each time slot which sources should\nsend their updates in such a way to minimize the Mean Age of Incorrect\nInformation (MAoII). The difficulty of the problem lies in the fact that the\nscheduler cannot know the states of the sources before receiving the updates\nand it has then to optimally balance the exploitation-exploration trade-off. We\nshow that the problem can be modeled as a partially Observable Markov Decision\nProcess Problem framework. We develop a new scheduling scheme based on\nWhittle's index policy. The scheduling decision is made by updating a belief\nvalue of the states of the sources, which is to the best of our knowledge has\nnot been considered before in the Age of Information area. To that extent, we\nproceed by using the Lagrangian Relaxation Approach, and prove that the dual\nproblem has an optimal threshold policy. Building on that, we shown that the\nproblem is indexable and compute the expressions of the Whittle's indices.\nFinally, we provide some numerical results to highlight the performance of our\nderived policy compared to the classical AoI metric.\n
Improving eco-efficiency of Amsterdam water supply: A LCA approach (2002)

Research Article| June 01 2002 Improving eco-efficiency of Amsterdam water supply: A LCA approach P. K. Mohapatra; P. K. Mohapatra 1Office of the Chief Engineer (Public Health), Heads of the Department Building, 1st Floor, Bhubaneswar-751 001, Orissa, India Search for other works by this author on: This Site PubMed Google Scholar M. A. Siebel; M. A. Siebel 2IHE, Delft, POB 3015, 2601 DA Delft, The Netherlands E-mail: mas@ihe.nl Search for other works by this author on: This Site PubMed Google Scholar H. J. Gijzen; H. J. Gijzen 2IHE, Delft, POB 3015, 2601 DA Delft, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar J. P. van der Hoek; J. P. van der Hoek 3Amsterdam Water Supply, Vogelenzangseweg 21, 2114 BA Vogelenzang, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar C. A. Groot C. A. Groot 3Amsterdam Water Supply, Vogelenzangseweg 21, 2114 BA Vogelenzang, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Journal of Water Supply: Research and Technology-Aqua (2002) 51 (4): 217–227. https://doi.org/10.2166/aqua.2002.0019 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Tools Icon Tools Cite Icon Cite Permissions Search Site Search nav search search input Search input auto suggest search filter All ContentAll JournalsThis Journal Search Advanced Search Citation P. K. Mohapatra, M. A. Siebel, H. J. Gijzen, J. P. van der Hoek, C. A. Groot; Improving eco-efficiency of Amsterdam water supply: A LCA approach. Journal of Water Supply: Research and Technology-Aqua 1 June 2002; 51 (4): 217–227. doi: https://doi.org/10.2166/aqua.2002.0019 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Amsterdam Water Supply produces 70 million m3 drinking water per annum in its Leiduin plant and is considering increasing the plant capacity to 83 million m3 per annum. The existing plant is a conventional surface water treatment plant. For capacity expansion, two alternative treatment schemes, each using reverse osmosis, are being considered. In these considerations, environmental impact plays an important role. Environmental impact of the plant was assessed with life cycle analysis. The total impact for annual production from the existing and the two future alternative schemes are 2.89E+04, 3.65E+04 and 3.44E+04 eco-points respectively. The significant impact contributors are the use of conventional energy, softening and the granular activated carbon process. Impact reduction up to 73% may be achieved by the use of 100% green energy, the use of an alternative chemical [Na2CO3 in place of NaOH] in the softening process and doubling the carbon run time. eco-indicator, environmental impact, life cycle analysis, reverse osmosis, sensitivity analysis, water treatment This content is only available as a PDF. © IWA Publishing 2002 You do not currently have access to this content.
Qualitative Beurteilung der Tympanoplastik mittels der endoskopischen optischen Kohärenztomografie (2019)

Die endoskopische optische Kohärenztomografie (eOCT) erlaubt die direkte kontaktfreie Darstellung und Beurteilung sowohl der Trommelfellmorphologie, des Trommelfellschwingungsverhaltens als auch eines Teils des angrenzenden Paukenhöhleninhaltes. Daher ist nach Weiterentwicklung der Messtechnik die EOCT zur Beurteilung der Ergebnisse einer Tympanoplastik in vivo einetzbar.
The Fiber Optic Gyroscope: Past and Present (2014)

A brief summary of the performance limitations of fiber optic gyroscopes interrogated with a broadband light source is presented, followed by a description of the status of current research efforts to push back these limitations by using an air-core fiber instead of a conventional fiber in the sensing coil, and/or coherent instead of incoherent light.
Discussion (1999)

Department of Neurological Surgery University of Florida College of Medicine Gainesville, Florida, U.S.A.
Mycenon, a new metabolite from a Mycena species TA 87202 (basidiomycetes) as an inhibitor of isocitrate lyase. (1990)

Mycenon (C11H5Cl3O3), a new inhibitor of isocitrate lyase (EC 4.1.3.1) was isolated from the culture broth of a basidiomycete, Mycena sp. Mycenon is a novel chlorinated benzoquinone derivative which is also active against bacteria and fungi. Malate synthase (EC 4.1.3.2) the second key enzyme of the glyoxylate cycle was not affected by mycenon. Isocitrate lyase preparations from plants, bacteria and fungi were sensitive. The following Ki-values for mycenon have been determined: Ricinus communis, 5.2 microM; Acinetobacter calcoaceticus, 11 microM; Neurospora crassa, 7.4 microM. The structure of mycenon has been determined by a single crystal X-ray analysis.
Rheumatic manifestations of lymphoproliferative disorders. (2007)

This article addresses several of the problems rheumatologists may experience with the various rheumatologic manifestations of lymphoproliferative disorders. Until more definitive data are available, patients who develop unexpected arthritis should be considered for histologic biopsy to rule out coexistent neoplasia.
Observation of New Baryons in the $Ξ_{b}^{-}π^{+}π^{-}$ and $Ξ_{b}^{0}π^{+}π^{-}$ Systems (2023)

The first observation and study of two new baryonic structures in the final state Ξ_{b}^{0}π^{+}π^{-} and the confirmation of the Ξ_{b}(6100)^{-} state in the Ξ_{b}^{-}π^{+}π^{-} decay mode are reported using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb^{-1}. In addition, the properties of the known Ξ_{b}^{*0}, Ξ_{b}^{'-} and Ξ_{b}^{*-} resonances are measured with improved precision. The new decay mode of the Ξ_{b}^{0} baryon to the Ξ_{c}^{+} π^{-} π^{+} π^{-} final state is observed and exploited for the first time in these measurements.
A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA -Mutated Breast and Gynecologic Cancers (2017)

<b>Purpose:</b> This phase I, open-label study (Study 1, D3610C00001; NCT01226316) was the first-in-human evaluation of oral AZD5363, a selective pan-AKT inhibitor, in patients with advanced solid malignancies. The objectives were to investigate the safety, tolerability, and pharmacokinetics of AZD5363, define a recommended dosing schedule, and evaluate preliminary clinical activity.<b>Experimental Design:</b> Patients were aged ≥18 years with World Health Organization (WHO) performance status of 0 to 1. Dose escalation was conducted within separate continuous and intermittent [4 days/week (4/7) or 2 days/week (2/7)] schedules with safety, pharmacokinetic, and pharmacodynamic analyses. Expansion cohorts of approximately 20 patients each explored AZD5363 activity in <i>PIK3CA</i>-mutant breast and gynecologic cancers.<b>Results:</b> MTDs were 320, 480, and 640 mg for continuous (<i>n</i> = 47), 4/7 (<i>n</i> = 21), and 2/7 (<i>n</i> = 22) schedules, respectively. Dose-limiting toxicities were rash and diarrhea for continuous, hyperglycemia for 2/7, and none for 4/7. Common adverse events were diarrhea (78%) and nausea (49%) and, for Common Terminology Criteria for Adverse Events grade ≥3 events, hyperglycemia (20%). The recommended phase II dose (480 mg bid, 4/7 intermittent) was assessed in <i>PIK3CA</i>-mutant breast and gynecologic expansion cohorts: 46% and 56% of patients, respectively, showed a reduction in tumor size, with RECIST responses of 4% and 8%. These responses were less than the prespecified 20% response rate; therefore, the criteria to stop further recruitment to the <i>PIK3CA</i>-mutant cohort were met.<b>Conclusions:</b> At the recommended phase II dose, AZD5363 was well tolerated and achieved plasma levels and robust target modulation in tumors. Proof-of-concept responses were observed in patients with <i>PIK3CA</i>-mutant cancers treated with AZD5363. <i>Clin Cancer Res; 24(9); 2050-9. ©2017 AACR</i><i>See related commentary by Costa and Bosch, p. 2029</i>.
Disease Burden ofClostridium difficileInfections in Adults, Hong Kong, China, 2006–2014 (2017)

Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world's population.
GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell model (2016)

This iPSC-derived NPC model provides the first evidence for an early neurodevelopmental phenotype in SPG11, with GSK3ß as a potential novel target to reverse the disease phenotype. Ann Neurol 2016;79:826-840.
EQS: Neighbor Discovery and Rendezvous Maintenance with Extended Quorum System for Mobile Sensing Applications (2012)

In many mobile sensing applications devices need to discover new neighbors and maintain the rendezvous with known neighbors continuously. Due to the limited energy supply, these devices have to cycle their radios to conserve energy, making neighbor discovery and rendezvous maintenance even more challenging. To date, the main mechanism for device discover and rendezvous maintenance in existing solutions is pair wise, direct one-hop communication. We argue that such pair wise direct communication is sufficient but not necessary: there exist unnecessary active slots that can be eliminated, without affecting discovery and rendezvous. In this work, we propose a novel concept of extended quorum system, which leverages indirect discovery to further conserve energy. Specifically, we use quorum graph to capture all possible information flow paths where knowledge about known-neighbors can propagate among devices. By eliminating redundant paths, we can reduce the number of active slots significantly. Since a quorum graph can characterize arbitrary active schedules of mobile devices, our work can be broadly used to improve many existing quorum based discovery and rendezvous solutions. The simulation and test bed experimental results show that our solution can reduce as much as 55% energy consumption with a maximal 5% increase in latency for existing solutions.
T2 Mapping of the myocardium, a quantitative tool for assessment of myocarditis (2012)

Background To quantify myocardial T2 value in patients with myocarditis and correlate the distribution of abnormal T2 values with the extent of macroscopic late gadolinium enhancement (LGE). Methods 25 patients with myocarditis were retrospectively evaluated for the utility of T2 mapping in diagnosing myocarditis. Patients with elevated troponins, negative coronary angiogram, and atypical LGE were diagnosed as acute myocarditis. Patients with normal troponins and macroscopic LGE at the time of cardiac MRI were diagnosed as remote myocarditis. As per our institutional protocol, T2 mapping sequences were performed in all cases with suspected myocarditis in addition to standard LGE images on 1.5 T scanner (Magnetom Aera and Avanto, Siemens medical solutions). T2 mapping was performed on three short axis images (base, mid chamber, and apex), yielding 16 myocardial segments for analysis (AHA segments). Single 4 chamber view image was obtained in addition. Minimum, peak and mean segmental T2 values were calculated by the first reader. Average segmental T2 values were documented along with documentation of the number of segments with elevated T2 values. The presence or absence of LGE was documented by a second reader blinded to the T2 results. Average segmental T2 values were then correlated with troponin levels at the time of the MRI examination. Results In patients with acute myocarditis, mean T2 values were elevated in segments showing LGE (average T2 value of 70 msec). The T2 values were also elevated in myocardial segments with no macroscopic LGE (avg 60 msec). On an average, there were 6 additional segments that showed elevated T2 values and no macroscopic LGE. In patients with remote myocarditis, the T2 values were normal in areas of LGE.
Segregation and Coactivation of Developing Neocortical Layer 1 Neurons (2003)

Layer 1 in the developing cerebral cortex is populated by two basic neuronal cell types, Cajal-Retzius (CR) cells and non-CR cells. We generated transgenic mice in which green fluorescent protein (GFP) was driven by the promoter of metabotropic glutamate receptor subtype 2 and expressed specifically in CR cells during cortical development. On the basis of the precise identification of CR cells with GFP fluorescence, we pursued developmental changes and synaptic mechanisms of both CR and non-CR cells during the postnatal period. Immunostaining in combination with GFP fluorescence imaging showed that GFP and reelin, a protein involved in corticogenesis, completely overlap in CR cells at postnatal day 0. At the subsequent postnatal stage, reelin-positive neurons are segregated and categorized into GFP-positive/GABA-negative CR cells and GFP-negative/GABA-positive non-CR cells. Individual and simultaneous whole-cell recordings of CR and non-CR cells in developing cerebral slices revealed that spontaneous and electrically evoked postsynaptic currents (sPSCs and ePSCs) measured in CR and non-CR cells are differentially mediated by GABA(A) receptors versus GABA(A), AMPA, and NMDA receptors, respectively. Furthermore, CR and non-CR cells show synchronized repetitive barrages of sPSCs that reflect a network-driven activity in the developing cerebral cortex. These findings imply that the layer 1 neurons dynamically change and play a distinct and integral role in the postnatal developing neocortex.
Waveform design based on Phase Conjugation and Time Reversal (2012)

Time Reversal theory and development for RADAR applications
A Machine Learning Solution for Beam Tracking in mmWave Systems (2019)

Utilizing millimeter-wave (mmWave) frequencies for wireless communication in mobile systems is challenging since it requires continuous tracking of the beam direction. Recently, beam tracking techniques based on channel sparsity and/or Kalman filter-based techniques were proposed where the solutions use assumptions regarding the environment and device mobility that may not hold in practical scenarios. In this paper, we explore a machine learning-based approach to track the angle of arrival (AoA) for specific paths in realistic scenarios. In particular, we use a recurrent neural network (R-NN) structure with a modified cost function to track the AoA. We propose methods to train the network in sequential data, and study the performance of our proposed solution in comparison to an extended Kalman filter based solution in a realistic mmWave scenario based on stochastic channel model from the QuaDRiGa framework. Results show that our proposed solution outperforms an extended Kalman filter-based method by reducing the AoA outage probability, and thus reducing the need for frequent beam search.
Association of drugs with special caution in the guidelines with falls: A case–control and case–crossover study in Japan (2021)

The drugs to be prescribed with special caution according to the guidelines were associated with an increased fall risk. The risk of falls in hospitalized older people due to multiple medications varies among medications. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2021; ••: ••-••.
5kV/200ns Pulsed Power Switch based on a SiC-JFET Super Cascode (2008)

In many pulse power applications there is a trend to modulators based on semiconductor technology. For these modulators high voltage and high current semiconductor switches are required in order to achieve a high pulsed power. Therefore, often high power IGBT modules or IGCT devices are used. Since these devices are based on bipolar technology the switching speed is limited and the switching losses are higher. In contrast to bipolar devices unipolar ones (e.g. SiC JFETs) basically offer a better switching performance. Moreover, these devices enable high blocking voltages in case large bandgap materials as SiC are used. At the moment SiC JFET devices with a blocking voltage of 1.5 kV per JFET are available. Alternatively, the operating voltage could be increased by connecting N JFETs and a low voltage MOSFET in series resulting in a Super Cascode switch with a blocking voltage N-times higher than the blocking voltage of a single JFET. In order to evaluate the achievable switching speed of the Super Cascode and its applicability in solid state modulators, the performance of such a SiC switch is examined in this paper. Furthermore, the performance of the Super Cascode is compared with 4.5 kV IGBTs made by Powerex, which are mounted in a special low inductive housing for minimising the rise and fall times.
Modal characterization of nanophotonic waveguides for atom trapping (2016)

Nanophotonic waveguides are a promising platform to trap cold atoms using red-and blue-detuned evanescent-field optical dipole forces. The asymmetric structure of integrated waveguides leads to a large birefringence that is not encountered in cylindrically symmetric optical nanofibers. We have studied both theoretically and experimentally the modal properties and suitability of silicon nitride rib waveguides for cold-atom trapping. The dependence of the modal effective index on the rib width is explored experimentally by measuring beat lengths between propagating modes. These measurements are made using a novel spatial Fourier analysis technique based on conventional far-field imaging of elastic scattering from the waveguide. We find that the beat length between the lowest order TE00 and TM00 modes is approximately 5µm, in excellent agreement with numerical calculations. We propose to take advantage of this birefringence and mode structure to create novel, one-dimensional periodic trapping potentials for atoms within the evanescent field of the waveguide.
A UAV-Mountable Flat Array Antenna System (2019)

In this paper, we suggest a method to design a small antenna system apt for the attachment to the drone with multi-propellers. Since each of multi-propellers is part of a branch connected to the center of the drone, a flat radial power divider is designed to feed antennas adhering to the propellers, instead of the Wilkinson power divider. For the frequency of 2.4 GHz to build a wireless link between the quadcopter and the ground, the 4-way radial power divider and 4 antennas are designed for the same frequency and light weight.
Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect (2017)

Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the multivalent character of the antibody-functionalized polymer lowered the effective concentration required for T-cell activation. This was evidenced for both early and late stages of activation. The most important effect observed was the significantly prolonged activation of the stimulated T cells, indicating that multivalent sDCs sustain T-cell signaling. Our results highlight the importance of multivalency for the design of aAPCs and will ultimately allow for better mimics of natural dendritic cells that can be used as vaccines in cancer treatment.
Two-Color Picosecond Pulse Generation Using Single-Stage Electro-Optic Mach-Zehnder Modulator (2008)

We demonstrated two-color picosecond pulse generation using Mach-Zehnder-modulator-based flat comb generator. Parabolic phase compensation of the comb with a dispersion-flattened fiber yields colorless operation. 10-GHz 4-ps pulse trains were simultaneously generated at two different wavelengths.
In search of Leonardo: computer-based facial image analysis of Renaissance artworks for identifying Leonardo as subject (2012)

One of the enduring mysteries in the history of the Renaissance is the adult appearance of the archetypical "Renaissance Man," Leonardo da Vinci. His only acknowledged self-portrait is from an advanced age, and various candidate images of younger men are difficult to assess given the absence of documentary evidence. One clue about Leonardo's appearance comes from the remark of the contemporary historian, Vasari, that the sculpture of David by Leonardo's master, Andrea del Verrocchio, was based on the appearance of Leonardo when he was an apprentice. Taking a cue from this statement, we suggest that the more mature sculpture of St. Thomas, also by Verrocchio, might also have been a portrait of Leonardo. We tested the possibility Leonardo was the subject for Verrocchio's sculpture by a novel computational technique for the comparison of three-dimensional facial configurations. Based on quantitative measures of similarities, we also assess whether another pair of candidate two-dimensional images are plausibly attributable as being portraits of Leonardo as a young adult. Our results are consistent with the claim Leonardo is indeed the subject in these works, but we need comparisons with images in a larger corpora of candidate artworks before our results achieve statistical significance.