gebhart/patrepeval huggingface dataset:
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents (2020)

Membrane-catalysed misfolding of islet amyloid polypeptide is associated with the death of β-cells in type II diabetes (T2D). Most active compounds so far reported require high doses for inhibition of membrane bound IAPP fibrillation. Here, we describe a naphthalimide-appended oligopyridylamide-based α-helical mimetic, <b>DM 1</b>, for targeting membrane bound IAPP. <b>DM 1</b> completely inhibits the aggregation of IAPP at doses of 0.2 equivalents. <b>DM 1</b> is also effective at similarly low doses for inhibition of seed-catalyzed secondary nucleation. An NMR based study demonstrates that <b>DM 1</b> modulates IAPP self-assembly by stabilizing and/or perturbing the N-terminus helix conformation. <b>DM 1</b> at substoichiometric doses rescues rat insulinoma cells from IAPP-mediated cytotoxicity. Most importantly, 0.2 equivalents of <b>DM 1</b> disaggregate preformed oligomers and fibrils and can reverse cytotoxicity by modulating toxic preformed oligomers and fibrils of IAPP into non-toxic conformations.
Texture and microstructural evolution of thin silver films in Ag/Ti bilayers (1998)

The texture and microstructure of thin silver films in Ag/Ti bilayer structures have been characterized as a function of vacuum annealing temperature and time with the use of x-ray diffraction and transmission electron microscopy. A strong preexisting (111) texture in Ag films was further improved upon annealing as evidenced by an increased intensity and narrower distribution of the texture along the film normal. A new (200) texture component was generated after 600 °C annealing; it however had a relatively low intensity when compared to the dominant (111) texture. No abnormal grain growth was observed in annealed Ag films. The texture evolution in all films appeared to complete within the first 15 min annealing, while the microstructure continued to change with additional annealing time. The roles of both surface energy and strain energy in the grain growth were evaluated. A model of the grain growth and texture evolution has been proposed to explain these observations.
Performance and Coexistence Evaluation of IEEE 802.11be Multi-link Operation (2022)

Wi-Fi 7 is already in the making, and Multi-Link Operation (MLO) is one of the main features proposed in its correspondent IEEE 802.11be amendment. MLO will allow devices to coordinate multiple radio interfaces to access separate channels through a single association, aiming for improved throughput, network delay, and overall spectrum reuse efficiency. In this work, we study three reference scenarios to evaluate the performance of the two main MLO implementations -- Multi-Link Multi-Radio (MLMR) and Multi-Link Single-Radio (MLSR) -- , the interplay between multiple nodes employing them, and their coexistence with legacy Single-Link devices. Importantly, our results reveal that the potential of MLMR is mainly unleashed in isolated deployments or under unloaded network conditions. Instead, in medium- to high-load scenarios, MLSR may prove more effective in reducing the latency while guaranteeing fairness with contending Single-Link nodes.
Detection of identical events from broadcasted sports video by comparing camera works (2001)

If identical events in a video stream can be recognized, it will become useful information for organizing the continuous media. In broadcasted sports video, there are scenes called which include important events identical to the live scenes. In this paper, we propose a new method fro detection of identical events by analyzing and matching of the live and replay scenes for broadcasted video of American football. The proposed method pays attention to camera works, because we consider that the works of different cameras that track identical events may move in a similar way. The basic experimental results show that this method is effective for detection of identical events.
Lubricin/proteoglycan 4 detected in vocal folds of humans and five other mammals (2019)

NA Laryngoscope, 129:E229-E237, 2019.
Suppression of spontaneous oscillations in high-frequency stimulated neuron models (2017)

We analyze the influence of high-frequency current stimulation on spontaneous neuronal activity and show that it may cause a death of spontaneous low-frequency oscillations. We demonstrate the universality of this effect for typical neuron models such as FitzHugh–Nagumo, Morris–Lecar, and Hodgkin–Huxley neurons as well as for the normal form of the supercritical Hopf bifurcation. Using a multiple scale method we separate the solutions of the neuron equations into slow and fast components and derive averaged equations for the slow components. The mechanism of suppression of neuronal activity is explained by an analysis of the bifurcations in the averaged equations governing the dynamics of the slow motion. Our results may contribute to the understanding of therapeutic effects of high-frequency deep brain stimulation, the golden standard for the treatment of medically refractory patients suffering from Parkinson’s disease. Furthermore, our study enables hypotheses concerning possible improvements of high-frequency deep brain stimulation.
CYCLOTRON LABORATORY QUARTERLY PROGRESS REPORT, 1 JUNE-31 AUGUST 1964 (1964)

Abstract : Content: Quasi-free proton-proton scattering, Investigation of the Faraday cup, Neutron total cross sections, n-p incoherent scattering cross section, Biological uses of proton beams, Test of the chew-low extrapolation method, Fission of medium-weight elements, Isotopic ratio studies of stable elements in the marine environment, Nuclear Magnetism and Nuclear Spectroscopy, Research on the properties of nuclei, Muclear interactions in molecules, Resonance studies with free ions.
High-Pressure Reactivity of Triptycene Probed by Raman Spectroscopy (2016)

The high-pressure reactivity of caged olefinic carbons and polyatomic aromatic hydrocarbons (PAHs) are of interest because of their ability to produce unique C–H networks with varying geometries and bonding environments. Here, we have selected triptycene to explore the creation of pores via high-pressure polymerization. Triptycene has internal free volume on a molecular scale that arises due to its paddle wheel-like structure, formed via fusion of three benzene rings via sp3-hybridized bridgehead carbon sites. At 25 GPa and 298 K, triptycene polymerizes to yield an amorphous hydrogenated carbon, with FTIR indicating an sp3 C–H content of approximately 40%. Vibrational spectroscopy conclusively demonstrates that triptycene polymerizes via cycloaddition reactions at the aromatic sites via a ring opening mechanism. The bridgehead carbons remain intact after polymerization, indicating the rigid backbone of the triptycene precursor is retained in the polymer, as well as molecular-level (∼1–3 Å) internal free volume. High resolution transmission electron microscopy, combined with dark field imaging, indicates the presence of ∼10 nm voids in the polymer, which we attribute to either polymeric clustering or a hierarchical tertiary porous network. Creation of a polymerized network that retains internal voids via high-pressure polymerization is attributed to the presence and retention of the bridgehead carbons.
A biometric approach to aesthetic crown lengthening: part II--interdental considerations. (2008)

Optimizing the aesthetic outcome for patients requiring periodontal aesthetic restorative treatment has become a primary objective in contemporary dentistry. Techniques that simplify and enhance quality of treatment provide substantial benefits to patients and clinicians. This article describes new concepts associated with interdental changes due to alterations in tooth and contact area position, and addresses the need for treatment of the interdental papillae. An innovative approach to aesthetic interdental periodontal crown lengthening will be discussed.
Method and apparatus for maintaining data coherence in a non-uniform compute device (2023)

A data processing apparatus includes one or more host processors with first processing units, one or more caches with second processing unit, a non-cache memory having a third processing unit and a reorder buffer operable to maintain data order during execution of a program of instructions. An instruction scheduler routes instructions to the processing units. Data coherence is maintained by control logic that blocks access to data locations in use by a selected processing unit other than the selected processing unit until data associated with the data locations are released from the reorder buffer. Data stored in the cache is written to the memory if it is already in a modified state, otherwise the state is set to the modified state. A memory controller may be used to restrict access to memory locations to be operated on.
Benchmarking of Beyond-CMOS Exploratory Devices for Logic Integrated Circuits (2015)

A new benchmarking of beyond-CMOS exploratory devices for logic integrated circuits is presented. It includes new devices with ferroelectric, straintronic, and orbitronic computational state variables. Standby power treatment and memory circuits are included. The set of circuits is extended to sequential logic, including arithmetic logic units. The conclusion that tunneling field-effect transistors are the leading low-power option is reinforced. Ferroelectric transistors may present an attractive option with faster switching delay. Magnetoelectric effects are more energy efficient than spin transfer torque, but the switching speed of magnetization is a limitation. This article enables a better focus on promising beyond-CMOS exploratory devices.
Calculation of the optical force on an infinite cylinder with arbitrary cross section by the boundary element method (2008)

We have developed and implemented a numerical scheme to compute optical forces in two-dimensional (2D) structures based on the boundary integral equations, which are solved by the numerical boundary element method. We demonstrate the efficiency of this method by calculating the optical scattering and radiation pressures exerted on 2D objects under the illumination of both plane wave and cylindrical Gaussian beams. The results are validated by comparing to analytical Mie scattering results on circular cylinders. In the framework of this approach the object can be of arbitrary shape with dimensions either far larger, comparable, or much less than the wavelength concerned, and the constituent components can be either dielectric or metallic. We applied the method to study the resonance enhancement of optical forces and the effect of surface roughness on such enhancement. Surprisingly, we found that a cylinder with “controlled roughness” can give a stronger optical force than a smooth surface at resonance.
ChemInform Abstract: Synthesis and Structure of a Novel Polysilicate Cs4(NbO)2(Si8O21). (1990)

Abstract The title compound is obtained as a single phase from the reaction of stoichiometric amounts of CsNO 3 , Nb 2 O 5 , and SiO 2 (723 K, 6 h; 1373 K, 24 h; air, Pt‐crucible).
Proapoptotic Peptide-Mediated Cancer Therapy Targeted to Cell Surface p32 (2013)

Antiangiogenic therapy is a promising new treatment modality for cancer, but it generally produces only transient tumor regression. We have previously devised a tumor-targeted nanosystem, in which a pentapeptide, CGKRK, delivers a proapoptotic peptide into the mitochondria of tumor blood vessel endothelial cells and tumor cells. The treatment was highly effective in glioblastoma mouse models completely refractory to other antiangiogenic treatments. Here, we identify p32/gC1qR/HABP, a mitochondrial protein that is also expressed at the cell surface of activated (angiogenic) endothelial cells and tumor cells, as a receptor for the CGKRK peptide. The results demonstrate the ability of p32 to cause internalization of a payload bound to p32 into the cytoplasm. We also show that nardilysin, a protease capable of cleaving CGKRK, plays a role in the internalization of a p32-bound payload. As p32 is overexpressed and surface displayed in breast cancers, we studied the efficacy of the nanosystem in this cancer. We show highly significant treatment results in an orthotopic model of breast cancer. The specificity of cell surface p32 for tumor-associated cells, its ability to carry payloads to mitochondria, and the efficacy of the system in important types of cancer make the nanosystem a promising candidate for further development.
Compact Surface Plasmon Resonance System with Au/Si Schottky Barrier (2018)

Ethanol concentration was quantified by the use of a compact surface plasmon resonance (SPR) system, which electrically detects hot electrons via a Schottky barrier. Although it is well known that SPR can be used as bio/chemical sensors, implementation is not necessarily practical, due to the size and cost impediments associated with a system with variable wavelength or angle of incidence. However, scanning capability is not a prerequisite if the objective is to use SPR in a sensor. It is possible to build a small, inexpensive SPR sensor if the optics have no moving parts and a Schottky barrier is used for electrical current detection in place of a photodetector. This article reports on the design and performance of such a novel SPR sensor, and its application for quantifying ethanol concentration. As the concentration of ethanol is increased, the change in the angle dependence of the SPR current is observed. This change can be understood as a superposition of contributions of SPR coupled with the +3rd- and -3rd-order diffraction. Moreover, real-time monitoring of ethanol concentration was demonstrated using the proposed SPR system.
Efficient Parallel LOD-FDTD Method for Debye-Dispersive Media (2014)

The locally one-dimensional finite-difference time-domain (LOD-FDTD) method is a promising implicit technique for solving Maxwell's equations in numerical electromagnetics. This paper describes an efficient message passing interface (MPI)-parallel implementation of the LOD-FDTD method for Debye-dispersive media. Its computational efficiency is demonstrated to be superior to that of the parallel ADI-FDTD method. We demonstrate the effectiveness of the proposed parallel algorithm in the simulation of a bio-electromagnetic problem: the deep brain stimulation (DBS) in the human body. © 1963-2012 IEEE.
Unified classification model for geotagging websites (2012)

The paper presents a novel approach to finding regional scopes (geotagging) of websites. It relies on a single binary classification model per region type to perform the multi-class classification and uses a variety of features of different nature that have not been yet used together for machine-learning based regional classification of websites. The evaluation demonstrates the advantage of our "one model per region type" method versus the traditional "one model per region" approach.
Proliferationof Cancer-Related Genes and Suppresses Cell Blocking eIF5A Modification in Cervical Cancer Cells Alters the (2014)

Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancers, where it is widely overexpressed. eIF5A contains the distinctive amino acid hypusine, which is formed by a posttranslational modification event requiring deoxyhypusine hydroxylase (DOHH), an enzyme that can be inhibited by the drugs ciclopirox and deferiprone. We found that proliferation of cervical cancer cells can be blocked by DOHH inhibition with either of these pharmacologic agents, as well as by RNA interference–mediated silencing of eIF5A, DOHH, or another enzyme in the hypusine pathway. Proteomic and RNA analyses in HeLa cervical cancer cells identified two groups of proteins in addition to eIF5A that were coordinately affected by ciclopirox and deferiprone. Group 1 proteins (Hsp27, NM23, and DJ-1) were downregulated at the translational level, whereas group 2 proteins (TrpRS and PRDX2) were upregulated at the mRNA level. Further investigations confirmed that eIF5A and DOHH are required for Hsp27 expression in cervical cancer cells and for regulation of its key target IkB and hence NF-kB. Our results argue that mature eIF5A controls a translational network of cancer-driving genes, termed the eIF5A regulon, at the levels of mRNA abundance and translation. In coordinating cell proliferation, the eIF5A regulon can be modulated by drugs such as ciclopirox or deferiprone, which might be repositioned to control cancer cell growth. Cancer Res; 74(2); 552–62. 2013 AACR.
Broadly distributed T cell reactivity, with no immunodominant loci, to the pre-erythrocytic antigen thrombospondin-related adhesive protein of Plasmodium falciparum in West Africans (1999)

Protective immunity to malaria has been achieved in human volunteers utilizing the pre-erythrocytic Plasmodium falciparum antigen, the circumsporozoite protein (CS). However, T cell reactivity to CS is focused on several highly polymorphic T cell epitope regions, potentially limiting the efficacy of any vaccine to specific malaria strains. Another important pre-erythrocytic malaria antigen, the thrombospondin-related adhesive protein (TRAP), can induce protection in animal models of malaria, but knowledge of human T cell responses is limited to the identification of CD8 T cell epitopes, with no CD4 epitopes identified to date. This comprehensive study assessed reactivity to overlapping peptides spanning almost the whole of P. falciparum TRAP (PfTRAP), as well as peptides selected on the basis of HLA class II-binding motifs. A total of 50 naturally exposed Gambian adults were assessed to define 26 T cell epitopes in PfTRAP capable of inducing rapid IFN-γ or IL-4 production, as assessed by enzyme-linked immunospot assays. In contrast to the CS protein, this reactivity was broadly distributed along the length of TRAP. Moreover, of the 26 epitopes identified, 10 were found to be conserved in West Africa.
Additions and Corrections - Stable Uranium(IV) Alkyl and Aryl Complexes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Stable Uranium(IV) Alkyl and Aryl ComplexesTobin J. Marks and Afif M. SeyamCite this: J. Am. Chem. Soc. 1973, 95, 9, 3083Publication Date (Print):May 1, 1973Publication History Published online15 January 2004Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/ja00790a605https://doi.org/10.1021/ja00790a605research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Table 8 from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;Primer and probe list of genes used for quantitative Methylation Specific PCR in urine ccfDNA.&lt;/p&gt;
Curse or Redemption? How Data Heterogeneity Affects the Robustness of Federated Learning (2021)

Data heterogeneity has been identified as one of the key features in federated learning but often overlooked in the lens of robustness to adversarial attacks. This paper focuses on characterizing and understanding its impact on backdooring attacks in federated learning through comprehensive experiments using synthetic and the LEAF benchmarks. The initial impression driven by our experimental results suggests that data heterogeneity is the dominant factor in the effectiveness of attacks and it may be a redemption for defending against backdooring as it makes the attack less efficient, more challenging to design effective attack strategies, and the attack result also becomes less predictable. However, with further investigations, we found data heterogeneity is more of a curse than a redemption as the attack effectiveness can be significantly boosted by simply adjusting the client-side backdooring timing. More importantly, data heterogeneity may result in overfitting at the local training of benign clients, which can be utilized by attackers to disguise themselves and fool skewed-feature based defenses. In addition, effective attack strategies can be made by adjusting attack data distribution. Finally, we discuss the potential directions of defending the curses brought by data heterogeneity. The results and lessons learned from our extensive experiments and analysis offer new insights for designing robust federated learning methods and systems.
Guest Editorial: Modeling and Simulation Methods for Analysis and Design of Advanced Energy Conversion Systems (2020)

The papers in this special section examine modeling and simulation methods for the analysis and design of advanced energy conversion systems. Energy conversion lies aEnergyveral fronts including materials, conversion methods, power electronics, and controls have created new opportunities for efficient energy conversion from both the conventional and new sources of energy. Our urgent need to solve many critical problems with regards to the sustainability and security of our energy system as well as the ever-increasing environmental challenges facing humanity have further spurred unprecedented opportunities for creation of innovative solutions to address these challenges.
Intraoperative and postoperative feasibility and safety of total tubeless, tubeless, small-bore tube, and standard percutaneous nephrolithotomy: a systematic review and network meta-analysis of 16 randomized controlled trials (2017)

For hemoglobin changes, total tubeless and small-bore PCNLs may be superior to other methods. For hospital stay, total tubeless and tubeless PCNLs with stent may be superior to other procedures.
In Vitro–In Vivo Correlations Observed With Indacaterol-Based Formulations Delivered with the Breezhaler ® (2014)

Anatomical throat models represent an exciting tool to aid in formulation development of pharmaceutical aerosols.
A Proportionate NLMS Algorithm for the Identification of Sparse Bilinear Forms (2018)

Proportionate-type algorithms are designed to exploit the sparseness character of the systems to be identified, in order to improve the overall convergence of the adaptive filters used in this context. However, when the parameter space is large, the system identification problem becomes more challenging. In this paper, we focus on the identification of bilinear forms, where the bilinear term is defined with respect to the impulse responses of a spatiotemporal model. In this framework, we develop a proportionate normalized least-mean-square algorithm tailored for the identification of such bilinear forms. Simulation results indicate the good performance of the proposed algorithm, in terms of both convergence rate and computational complexity.