gebhart/patrepeval huggingface dataset:
Where is time spent in message-passing and shared-memory programs? (1994)

Message passing and shared memory are two techniques parallel programs use for coordination and communication. This paper studies the strengths and weaknesses of these two mechanisms by comparing equivalent, well-written message-passing and shared-memory programs running on similar hardware. To ensure that our measurements are comparable, we produced two carefully tuned versions of each program and measured them on closely-related simulators of a message-passing and a shared-memory machine, both of which are based on same underlying hardware assumptions. We examined the behavior and performance of each program carefully. Although the cost of computation in each pair of programs was similar, synchronization and communication differed greatly. We found that message-passing's advantage over shared-memory is not clear-cut. Three of the four shared-memory programs ran at roughly the same speed as their message-passing equivalent, even though their communication patterns were different.
Controlled-release systemic delivery - a new concept in cancer chemoprevention (2012)

Many chemopreventive agents have encountered bioavailability issues in pre-clinical/clinical studies despite high oral doses. We report here a new concept utilizing polycaprolactone implants embedded with test compounds to obtain controlled systemic delivery, circumventing oral bioavailability issues and reducing the total administered dose. Compounds were released from the implants in vitro dose dependently and for long durations (months), which correlated with in vivo release. Polymeric implants of curcumin significantly inhibited tissue DNA adducts following the treatment of rats with benzo[a]pyrene, with the total administered dose being substantially lower than typical oral doses. A comparison of bioavailability of curcumin given by implants showed significantly higher levels of curcumin in the plasma, liver and brain 30 days after treatment compared with the dietary route. Withaferin A implants resulted in a nearly 60% inhibition of lung cancer A549 cell xenografts, but no inhibition occurred when the same total dose was administered intraperitoneally. More than 15 phytochemicals have been tested successfully by this formulation. Together, our data indicate that this novel implant-delivery system circumvents oral bioavailability issues, provides continuous delivery for long durations and lowers the total administered dose, eliciting both chemopreventive/chemotherapeutic activities. This would also allow the assessment of activity of minor constituents and synthetic metabolites, which otherwise remain uninvestigated in vivo.
Synthesis and characterization of semicrystalline cycloaliphatic polyester/poly(dimethylsiloxane) segmented copolymers (1997)

High molecular weight poly(dimethylsiloxane)/semicrystalline cycloaliphatic polyester segmented copolymers based on dimethyl-1,4-cyclohexane dicarboxylate were prepared and characterized. The copolymers were synthesized using a high trans content isomer that afforded semicrystalline morphologies. Aminopropyl-terminated poly(dimethylsiloxane) (PDMS) oligomers of controlled molecular weight were synthesized, end capped with excess diester to form a diester-terminated oligomer, and incorporated via melt transesterification step reaction copolymerization. The molecular weight of the polysiloxane and chemical composition of the copolymer were systematically varied. The polysiloxane segment was efficiently incorporated into the copolymers via an amide link and its structure was unaffected by low concentrations of titanate transesterification catalyst, as shown by control melt experiments. The homopolymer and copolymers were characterized by solution, thermal, mechanical, and surface techniques. The segmented copolymers were microphase separated as determined by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and by transmission electron microscopy (TEM). It was demonstrated that relatively short poly(dimethylsiloxane) segment lengths and compositions were required to maintain single phase melt polymerization conditions. This was, in fact, the key to the successful preparation of these materials. The copolymers derived from short poly(dimethylsiloxane) segments demonstrated good mechanical properties, melt viscosities representative of single phase polymer melts, and were easily compression molded into films. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3495–3506, 1997
Series Voltage Compensation for DFIG Wind Turbine Low-Voltage Ride-Through Solution (2011)

This paper introduces a new solution for doubly fed induction generators to stay connected to the grid during voltage sags. The main idea is to increase the stator voltage to a level that creates the required flux to keep the rotor side converter current below its transient rating. To accomplish this goal, a series compensator is added to inject voltage in series to the stator side line. The series converter monitors the grid voltage and provides compensation accordingly to accomplish this aim. Since the turbine and converter stay connected, the synchronization of operation remains established during and after the fault and normal operation can be resumed immediately after the fault is cleared. To keep the current at its minimum, a control strategy has been developed to keep the injected voltage and line voltage in phase during and after the fault.
P2Y receptors in GtoPdb v.2021.3 (2021)

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [47, 110, 190, 383, 396]. Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [241], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [53, 323].
The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness (2022)

Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, and occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 is highly expressed in GBM tumor and immune cells and correlates with poor survival. In GBM, ADAM8 affects intracellular kinase signaling and increases expression levels of osteopontin/SPP1 and matrix metalloproteinase 9 (MMP9) by an unknown mechanism. Here we explored whether microRNA (miRNA) expression levels could be regulators of MMP9 expression in GBM cells expressing ADAM8. Initially, we identified several miRNAs as dysregulated in ADAM8-deficient U87 GBM cells. Among these, the tumor suppressor miR-181a-5p was significantly upregulated in ADAM8 knockout clones. By inhibiting kinase signaling, we found that ADAM8 downregulates expression of miR-181a-5p <i>via</i> activation of signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase (MAPK) signaling suggesting an ADAM8-dependent silencing of miR-181a-5p. In turn, mimic miR-181a-5p transfection caused decreased cell proliferation and lower MMP9 expression in GBM cells. Furthermore, miR-181a-5p was detected in GBM cell-derived extracellular vesicles (EVs) as well as patient serum-derived EVs. We identified miR-181a-5p downregulating MMP9 expression <i>via</i> targeting the MAPK pathway. Analysis of patient tissue samples (n=22) revealed that in GBM, miR-181a-5p is strongly downregulated compared to <i>ADAM8</i> and <i>MMP9</i> mRNA expression, even in localized tumor areas. Taken together, we provide evidence for a functional axis involving ADAM8/miR-181a-5p/MAPK/MMP9 in GBM tumor cells.
A Deep-Learning Based Real-Time Prediction of Seated Postural Limits and its Application in Trunk Rehabilitation (2022)

&lt;p&gt;Seated postural limit defines the region from beyond which a subject cannot return the trunk to the neutral position without additional external support. The seated postural limits can be used as a reference to provide assistive support to the torso by an appropriately designed robotics, e.g., Trunk Support Trainer (TruST). However, fixed boundary representations of seated postural limits in the literature cannot capture the dynamically changing seated postural limits during training. In this study, we propose a conceptual model of the dynamic boundary of the trunk center using a boundary vector designed to track the postural-goal direction and trunk movement amplitude during a sitting task. We experimented with 20 healthy subjects. The results support our hypothesis that TruST intervention with an assist-as-needed controller based on the proposed dynamic boundary representation could achieve more significant sitting workspace area improvements than a fixed boundary representation. The second contribution of this paper is that we provide an approach to effectively introduce deep learning into TruST's real-time controller design. We compiled a 3D trunk movement dataset which is currently the largest in the literature. We designed a loss capable of solving the gate-controlled regression problem. We proposed a novel roadmap for the exploration study. Following the roadmap, we developed a deep learning architecture, modified the widely used Inception module, and then obtained a deep learning model capable of accurately predicting the dynamic boundary in real-time. We believe this approach can be extended across other rehabilitation robots towards designing intelligent dynamic boundary-based assist-as-needed controllers.&lt;/p&gt;
GENE THERAPY IN ORTHOPAEDIC SURGERY (2002)

Gene therapy has the potential to revolutionize the treatment of a variety of musculoskeletal disorders. In the past decade, more than 4,000 patients have been enrolled in clinical trials involving gene therapy. Gene therapy is becoming increasingly important in modern orthopaedic clinical practice. It is important to discuss the issues that physicians and scientists face when designing an experiment or clinical trial involving gene therapy, along with the potential clinical applications for gene therapy in the treatment of patients with musculoskeletal problems.
Generation of bicyclo[3.1.0]hexatriene. Reactive intermediate (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneration of bicyclo[3.1.0]hexatriene. Reactive intermediateWilliam N. WashburnCite this: J. Am. Chem. Soc. 1975, 97, 6, 1615–1616Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/ja00839a078https://doi.org/10.1021/ja00839a078research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
4D simultaneous PP-PS prestack inversion in the Edvard Grieg field, Norwegian North Sea (2020)

Time-lapse seismic data allows for improved reservoir monitoring capabilities. The process involves the use of multiple vintages of seismic data covering a sufficient length of time with field development, acquired in the same area. In the Edvard Grieg field, the surveys were acquired two years apart in order to capture 4D response. Differences in the data produced by production and injection provide valuable information of saturation changes and pressure changes in the reservoir, illuminating permeability pathways, bypassed reservoir, water drive, and compartmentalization. A frequent challenge in interpretation of time-lapse signal is the interference between 4D effects, particularly pressure and saturation change. Presentation Date: Wednesday, October 14, 2020 Session Start Time: 9:20 AM Presentation Time: 11:00 AM Location: Poster Station 2 Presentation Type: Poster
A new test and characterization scheme for 10+ GHz low jitter wide band PLL (2006)

This paper presents a new test and characterization scheme for 10+ GHz low jitter wide band PLL in 90 nm partially depleted (PD) Silicon-On-Insulator (SOI) CMOS technology. We measure the frequency range of VCOs without adding any devices for test between charge-pump (CP) and voltage- controlled oscillator (VCO). That test scheme gives us the intermediate frequency of VCO as well as the maximum and the minimum frequency. This paper also describes circuitry to observe the duty cycle of 4.2GHz clock directly on a wafer probe station, including a method to verify the measured duty cycle.
Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts (1989)

Single cell [Ca2+], studies were performed in chicken and rat osteoclasts loaded with fura-2 and exposed to a variety of treatments. Under resting conditions, basal [Ca2+]i, was 79.2 +/- 47.3 and 84.3 +/- 65.7 nM (averages +/- S.D.; n = 141 and 126) in the osteoclasts of the two species, respectively. Basal [Ca2+]i was stable in all rat and in approximately 80% of chicken osteoclasts. In the remaining 20%, spontaneous, irregular [Ca2+], fluctuations were observed (amplitude range: 50-200 nm over basal values). Increase of [Ca2+]o over the concentration of the Krebs-Ringer incubation medium (2 mM) induced rises of [Ca2+] in almost all cells investigated. [Ca2+] rises were already appreciable with 0.5 mM [Ca2+]o additions and reached high values with 4 mM additions: 390 +/- 113 and 364 +/- 214 nM [Ca2+], in rat and chicken osteoclasts, respectively (n = 122 and 101). Qualitatively, the responses to [Ca2+]o additions consisted of discrete [Ca2+]i transients, biphasic (an initial spike followed by a plateau), or monophasic (either the spike or the plateau). In a few chicken osteoclasts, the [Ca2+]i increase occurring after [Ca2+]o addition consisted of multiple, irregular fluctuations, similar to those observed in 20% of these cells under resting conditions. In individual osteoclasts subsequently exposed to multiple [Ca2+]o increase pulses, the type of the [Ca2+]i transient (mono- or biphasic) was maintained, and the size was dependent on the magnitude of the [Ca2+]o additions. Effects similar to those of [Ca2+]o were induced by the addition of Cd2+ or Ba2+ (but not La3+ or Mg2+) into the medium. The Cd2+ effect was maintained in part even in a Ca2+-free medium. Of various hormones and factors, parathormone, 1,25-dihydroxyvitamin D3, and prostaglandin E2 were inactive. In contrast, calcitonin was active in rat osteoclasts (which express numerous receptors). [Ca2+]i increases were small (19 +/- 17.9 nM; n = 21) when the hormone was administered alone; they were synergistic (severalfold potentiation) when the hormone was administered before or after [Ca2+]o. The [Ca2+]i effects of calcitonin were mimicked by 8Br-cAMP (31 +/- 26 nM; n = 12) when the nucleotide was administered alone; marked synergism when it was administered in combination with [Ca2+]o. This paper demonstrates for the first time that changes of [Ca2+]i are induced in osteoclasts by treatments with [Ca2+]o and calcitonin and can therefore be involved in intracellular mediation of the physiological effects of these two extracellular signals.
Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3 (2012)

Our data suggest the occurrence of common susceptibility loci for epilepsy and migraine on chromosomes 14q12-q23 and 12q24.2-q24.3, implicating a shared genetic etiology for these 2 diseases.
Providing Adaptive Health Updates Across the Personal Social Network (2013)

This article presents research conducted to establish how information is shared across the personal social network in the sensitive context of a health crisis. We worked with parents of very sick babies who were cared for in a hospital's Neonatal Unit (NNU). Through a combination of interviews, a focus group, and surveys, we developed a user model of the information that parents wanted to share, and how they adapted this information to individual recipients. We then developed a prototype software tool which created adaptive updates for members of the parents' social network. The updates contained summaries of large volumes of complex medical data about the baby, nonmedical information about the parents, and practical information about the hospital. Updates were automatically adapted to individual members of parents' social networks, based on our user model. The tool was evaluated in a large NNU in the United Kingdom with parents of babies who were currently being cared for in the unit. We found that parents adapted the information that they shared about themselves and their babies based on the emotional proximity of their network members. They gave most detail to those who were emotionally closest to them and least to those who were less close. Parents also adapted information content to the recipient's tendency to worry and empathize. Two adaptive strategies were deployed by parents, (a) benign deceit—not telling the whole truth—and (b) promotion of empathetic members of the social network to a higher level of emotional proximity, so that they were given more information. We generated a number of directions for future work, and issues to consider around designing adaptive mediated communications systems for sensitive contexts. These include the potential to generalize our model to other medical contexts and considerations to apply when deliberately designing deceit into adaptive systems.
Concussion in Professional Football (2006)

With newer football helmets, there was a trend toward 10 to 20% lower risks of concussion in reconstructed National Football League game collisions. However, a few designs and cases showed increased responses. The evaluation of football helmets to the proposed National Operating Committee on Standards for Athletic Equipment concussion standard should lead to more uniform reductions in concussion risk with future football helmets.
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies (2022)

Metastatic castration-resistant prostate cancers (mCRPCs) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ARTs). Our previous work identified CREB5 as an upregulated target gene in human mCRPC that promoted resistance to all clinically approved ART. The mechanisms by which CREB5 promotes progression of mCRPC or other cancers remains elusive. Integrating ChIP-seq and rapid immunoprecipitation and mass spectroscopy of endogenous proteins, we report that cells overexpressing CREB5 demonstrate extensive reprogramming of nuclear protein-protein interactions in response to the ART agent enzalutamide. Specifically, CREB5 physically interacts with AR, the pioneering actor FOXA1, and other known co-factors of AR and FOXA1 at transcription regulatory elements recently found to be active in mCRPC patients. We identified a subset of CREB5/FOXA1 co-interacting nuclear factors that have critical functions for AR transcription (GRHL2, HOXB13) while others (TBX3, NFIC) regulated cell viability and ART resistance and were amplified or overexpressed in mCRPC. Upon examining the nuclear protein interactions and the impact of CREB5 expression on the mCRPC patient transcriptome, we found that CREB5 was associated with Wnt signaling and epithelial to mesenchymal transitions, implicating these pathways in CREB5/FOXA1-mediated ART resistance. Overall, these observations define the molecular interactions among CREB5, FOXA1, and pathways that promote ART resistance.
Abstract 908: A role for MST4 in organelle organization and breast cancer cell vascular invasion (2017)

Abstract There exist 5 Mammalian Sterile20-like (MST) kinases that are broadly distributed into two subgroups. While MST1 and MST2 have established roles in the canonical Hippo signaling pathway, MST3, MST4, and YSK1 are known to regulate the actin cytoskeleton and cell polarity. Here we clarify distinct roles for MST3 vs. MST4 in breast cancer cell lines. Stable knockdown of MST4, but not MST3, enhances the ability of breast cancer cells to disrupt an endothelial monolayer as well as invade from an endothelial network formed within a microfluidic device. In addition, depletion of MST4 in MDA-MB-231 cells alters their morphology, induces abnormalities in nuclear structure, and affects the organization of cellular organelles like the Golgi apparatus. We conclude that, despite their relative homology, MST4 versus MST3 uniquely impacts the intracellular organelle status and vascular invasive behavior of breast cancer cells. Citation Format: Eric B. Berens, Mara Gilardi, Matteo Moretti, Anna T. Riegel, Anton Wellstein. A role for MST4 in organelle organization and breast cancer cell vascular invasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 908. doi:10.1158/1538-7445.AM2017-908
Self-Limited Dehydration during Continuous A-V Hemofiltration (1984)

Continuous arteriovenous hemofiltration is a new technique in which fluid and solutes can be removed from the body by means of ultrafiltration generated only by the arteriovenous gradient. No machinery or specialized staff are required.Very small forces are operating in the system, making the kinetics of ultrafiltration different from any other extracorporeal circulation. Factors generally negligible – as protein concentration – play an important role in the ultrafiltrate production. A study of a patient in a condition of marked dehydration and, subsequently, with reinfusion fluid shows that even in the absence of adequate monitoring or care, the dehydration can be self-limited and may avoid dangerous complications.