gebhart/patrepeval huggingface dataset:
Towards a fully integrated, wirelessly powered, and ordinarily equipped on-lens system for successive dry eye syndrome diagnosis (2017)

This paper presents a smart contact lens (SCL) sensor system for successive evaluation of tear evaporation. The proposed SCL system integrated with 3D technology is composed of tunable sensitivity sensor-readout circuitry, a tear sensor, and an antenna, and is embedded into a biocompatible hydrogel-based contact lens by a commercial manufacturing process. Moreover, the on-lens system can be addressed using commercial radio-frequency identification (RFID) reader devices for sensor control and data communication. Subjects can wear the SCL for continuous tear-content monitoring. Furthermore, the recordings from the device can provide high distinguishability in different tear phantoms using a variation of capacitance or resistance rather than using the weight loss.
Omicron detection with large language models and YouTube audio data (2022)

Publicly available audio data presents a unique opportunity for the development of digital health technologies with large language models (LLMs). In this study, YouTube was mined to collect audio data from individuals with self-declared positive COVID-19 tests as well as those with other upper respiratory infections (URI) and healthy subjects discussing a diverse range of topics. The resulting dataset was transcribed with the Whisper model and used to assess the capacity of LLMs for detecting self-reported COVID-19 cases and performing variant classification. Following prompt optimization, LLMs achieved accuracies of 0.89, 0.97, respectively, in the tasks of identifying self-reported COVID-19 cases and other respiratory illnesses. The model also obtained a mean accuracy of 0.77 at identifying the variant of self-reported COVID-19 cases using only symptoms and other health-related factors described in the YouTube videos. In comparison with past studies, which used scripted, standardized voice samples to capture biomarkers, this study focused on extracting meaningful information from public online audio data. This work introduced novel design paradigms for pandemic management tools, showing the potential of audio data in clinical and public health applications.
Nonpetroleum-Based, No/Low-Sulphur, Ash, and Phosphorus, and Bio-No-Toxicity Engine Oil Development and Testing (2012)

More and more, engine oils must minimize or avoid their effect on the durability of particulate filters and catalysts, and in the future, on terrestrial and aquatic environments. They must also maximize their contribution to fuel economy. Replacing hydrocarbon-based oils with environmentally friendly products is one of the ways to reduce the adverse effects on the ecosystem caused by the use of lubricants. By analyzing recent technological evolutions and future trends in engine oil specifications, with the associated consequences for the functional properties performed by base oils and individual additives, the need and potential application of alternative base oils with intrinsic properties will be displayed. The focus of this chapter is on alternative base oils.
Supplementary Figure 5 from An <i>In Vivo</i> Immunotherapy Screen of Costimulatory Molecules Identifies Fc-OX40L as a Potent Reagent for the Treatment of Established Murine Gliomas (2023)

&lt;p&gt;PDF file, 380K, Histological Analysis of secondary malignancies.&lt;/p&gt;
The Correction of a Secondary Bilateral Cleft Lip Nasal Deformity Using Refined Open Rhinoplasty with Reverse-U Incision, V-Y Plasty, and Selective Combination with Composite Grafting: Long-term Results (2012)

A bilateral reverse-U incision with V-Y plasty or in combination with a composite graft was effective in correcting secondary bilateral cleft lip nasal deformity.
PHOENIX: A Scoring Function for Affinity Prediction Derived Using High-Resolution Crystal Structures and Calorimetry Measurements (2011)

Binding affinity prediction is one of the most critical components to computer-aided structure-based drug design. Despite advances in first-principle methods for predicting binding affinity, empirical scoring functions that are fast and only relatively accurate are still widely used in structure-based drug design. With the increasing availability of X-ray crystallographic structures in the Protein Data Bank and continuing application of biophysical methods such as isothermal titration calorimetry to measure thermodynamic parameters contributing to binding free energy, sufficient experimental data exists that scoring functions can now be derived by separating enthalpic (ΔH) and entropic (TΔS) contributions to binding free energy (ΔG). PHOENIX, a scoring function to predict binding affinities of protein-ligand complexes, utilizes the increasing availability of experimental data to improve binding affinity predictions by the following: model training and testing using high-resolution crystallographic data to minimize structural noise, independent models of enthalpic and entropic contributions fitted to thermodynamic parameters assumed to be thermodynamically biased to calculate binding free energy, use of shape and volume descriptors to better capture entropic contributions. A set of 42 descriptors and 112 protein-ligand complexes were used to derive functions using partial least-squares for change of enthalpy (ΔH) and change of entropy (TΔS) to calculate change of binding free energy (ΔG), resulting in a predictive r2 (r(pred)2) of 0.55 and a standard error (SE) of 1.34 kcal/mol. External validation using the 2009 version of the PDBbind "refined set" (n = 1612) resulted in a Pearson correlation coefficient (R(p)) of 0.575 and a mean error (ME) of 1.41 pK(d). Enthalpy and entropy predictions were of limited accuracy individually. However, their difference resulted in a relatively accurate binding free energy. While the development of an accurate and applicable scoring function was an objective of this study, the main focus was evaluation of the use of high-resolution X-ray crystal structures with high-quality thermodynamic parameters from isothermal titration calorimetry for scoring function development. With the increasing application of structure-based methods in molecular design, this study suggests that using high-resolution crystal structures, separating enthalpy and entropy contributions to binding free energy, and including descriptors to better capture entropic contributions may prove to be effective strategies toward rapid and accurate calculation of binding affinity.
616 Understanding the Sensory Characteristic in the Resonance Frequency of Human Body (2011)

Recently, the riding comfort of car passengers became as important as the driving performance and the control stability. In order to improve the riding comfort, it is necessary to evaluate comfort quantitatively and take increasing comfort measures. In this study we analyzed the effect of vibration on the riding comfort. First, we conducted vibration experiment using ordinary sine waves with two different directions, X (fore and aft)-Z (vertical) and Y (lateral)-Z (vertical) in order to investigate vibratory sensibility in the high frequency range, 4.0-8.0Hz. The parameter of the input vibration was amplitude ratio and frequency. As a result, a dispersion was confirmed in each subjects' characteristics of vibratory sensibility. Then, in older to classify of subjects, the vibration experiment was conducted with single direction, X (fore and aft), Y (lateral) and Z (vertical). We divided subjects into 3 groups from this result. Moreover, vibratory sensibility in the each group was investigated using frequency and amplitude ratio as input conditions. In this result, adequacy of the grouping was verified. Furthermore, the discomfort tended to increase with increasing the amplitude ratio X (fore and aft)-Z (vertical) in each group.
ChemInform Abstract: Practical Route to a New Class of LTD4 Receptor Antagonists. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Near-Infrared Fluorescent Imaging of Cerebral Thrombi and Blood–Brain Barrier Disruption in a Mouse Model of Cerebral Venous Sinus Thrombosis (2005)

An intravital microscopy imaging method was developed to visualize active cerebral thrombus and blood-brain barrier (BBB) disruption using Near Infrared Fluorescent (NIRF) probes. A circular craniotomy was made in CD-1 mice. Thrombi were formed by applying 10%-FeCl3 to the entire exposed superior sagittal sinus (SSS, 5 mm), or to the posterior 2.5 mm of the SSS for 5 mins. Control animals were pretreated with heparin (50 U/kg) before thrombus induction. Three hours after thrombus formation, a FXIIIa-targeted NIRF imaging probe (A15) was intravenously injected, and the SSS was imaged by intravital microscopy. This was followed by injection of indocyanine green (ICG) to assess BBB permeability. The A15 optical probe bound to thrombus, and the fluorescent signal emitted by the bound agent corresponded well with histologically confirmed thrombus. A15 initially remained intravascular, followed by excretion and subsequent decrease in all tissues except for thrombus, where it was retained. The subsequent ICG was also intravascular immediately after injection, but then began to leak into the cerebral parenchyma at 3 to 5 mins. The sites of leakage were adjacent to thrombosed areas. Heparin pretreatment prevented thrombus formation and reduced ICG leakage significantly. This demonstrates the feasibility of simultaneous in vivo monitoring of thrombus and BBB permeability in an animal model of cerebral venous thrombosis.
Preparation of Some 1,3-Selenazin-4-ones (1986)

Abstract 2-Cyano-3-hydroseleno-3-(methylthio)acrylamide reacts with carbonyl compounds in the presence of sulfuric acid and aroyl chlorides in the presence of pyridine to give the corresponding 2,3-dihydro-4H-1,3-selenazin-4-ones and 4H-1,3-selenazin-4-ones in moderate yields, respectively.
Utilization of Generic Consumer Modeling in Planning and Optimization of District Heating and Cooling Systems (2018)

District heating and cooling (DHC) networks are large scale complex systems which aregenerally difficult to operate and optimize. The large thermal inertia in the systems leadsto long reaction times on changes at the consumer side, which means that forecasting ofconsumer behaviour is a needed tool for efficient operation. Within the European Unionmany major research project target the energy reduction on the consumption side and peakload management while maintaining customer satisfaction.The optimal operation of a DHC network can therefore be considered as an interestingarea of investigation due to a number of aspects, like (i) the vast amount of the energy that is distributed by these networks, (ii) the demand to provide a better quality of services by the operators of these networks, and (iii) compliance with new environmental regulations. In this presentation, we discuss a possible conceptual method that utilizes a simpliedstatic model of different types of consumers in the network to design a decision supportsystem that will guide the operators of the DHC network to optimally operate the networkwith different operational scenarios that include but not limited to: (i) energy consumptionminimization, (ii) economic operation, (iii) peak load reduction/shifting, and (iv) environmentally friendly operation. In its current form, the operator will be informed, while in thefuture these actions could be fully automated in a closed loop context.The DHC network in Luleå, Sweden will be used as a test case which represents a typicalmedium size network. The case has a number of properties which motivate its study likee.g. the distributed generation possibilities, the geographical distribution of the consumers,and the different types of consumers in the area. The presentation will be concluded with anoutlook on future tracks of research and development
A study on motion measurement using inertial sensor and evaluation of standing with small translational acceleration (2019)

This study evaluates the effectiveness of the posture estimation method using an inertial sensor in the standing position generating small translational acceleration. The estimation method is established the sensor fusion algorithm focused on the local coordinate system by using the Extended Kalman filter, and we estimated 3D posture in the relative coordinate system from acceleration and angular velocity. The measurement experiment was conducted to clarify the accuracy of the estimation method using the disturbance generator, the wearable motion sensors installing inertial sensor and the motion capture system. We compared the result for ankle joint angle estimated by previous method and proposed method and focused on translational acceleration. We indicated the effectiveness of proposed method in the motion measurement of standing with small translational acceleration.
HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH H3K27M OR PDGFRA GENOMIC ALTERATIONS (2023)

Abstract PDGFRA is commonly altered in pediatric and young adult high-grade gliomas (pHGGs) including histone 3 lysine 27-mutated diffuse midline gliomas (H3K27M DMG), a fatal disease with no current options for cure. We performed comprehensive genomic and transcriptomic analyses of n=259 pediatric high-grade glioma cases which revealed PDGFRA genomic alterations in ~15% of patients. H3K27M DMGs had significantly higher PDGFRA expression compared to H3 wild-type tumors regardless of genomic alteration. Tumors with PDGFRA gene amplification demonstrated significantly elevated PDGFRA expression in both H3K27M DMGs and H3 wild-type pHGGs relative to tumors with wild-type or point mutated PDGFRA. We tested a range of PDGFRA inhibitors against a panel of patient derived pediatric H3K27M DMG, pHGG, and adult HGG. Amongst the inhibitors tested, avapritinib, a potent small molecule inhibitor with relatively selective activity against both wild-type and mutant PDGFRA showed potent toxicity against a wide array of pediatric and adult cell lines. This molecule also demonstrated supra-micromolar blood brain barrier penetration in pre-clinical in vivo models, and demonstrated significant decrease in tumor growth and improved survival in orthotopic mouse xenograft models. Finally, building on this preclinical activity, we report the first clinical experience using avapritinib in eight pediatric and young adult patients with high-grade glioma (H3K27M DMG and/or PDGFRA altered). Avapritinib usage showed no significant acute toxicities within this patient cohort. Most importantly, our preliminary data reveal radiographic response evaluated by RAPNO criteria in 50% of patients, a striking outcome rarely seen in this patient population. In summary, we report that avapritinib, a selective, CNS penetrant small molecule inhibitor of PDGFRA has potent activity in preclinical models and produced promising clinical responses with good tolerability in pediatric and young adult patients with high-grade glioma, suggesting a promising role for avapritinib therapy in pediatric high grade glioma.
Client-based ad insertion for adaptive video streaming (2014)

Advertisement is a crucial factor in business models of Internet video streaming. So far, most methods for advertisement video insertion are of server-based type. In this paper, we present an approach for client-based advertisement insertion in HTTP streaming, which has become a cost effective means for multimedia delivery. The advantages of our approach include client's unawareness of advertisement and smooth transition between content and advertisement.
Abstract 918: A secondary RET mutation allosterically conferring resistance to vandetanib (2018)

Abstract Targeted therapy against oncogenic ALK and ROS1 fusion using type I tyrosine kinase inhibitors (TKIs), which bind to the ATP-binding cleft of kinases, is highly effective in lung adenocarcinoma (LADC); however, such cancers inevitably acquire resistance, which severely limits the efficacy of cancer treatments. The identification of these resistance mutations led to the development of novel TKIs to overcome acquired resistance. Here we report resistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic LADC harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant tumor acquired a secondary mutation resulting in substitution of an amino acid located outside the nucleotide binding cleft. The mutation conferred resistance to vandetanib by increasing the ATP affinity and auto-phosphorylation activity of RET kinase. A crystal structure of the mutant revealed a small hydrophobic core around the mutated amino acid likely to enhance basal kinase activity by stabilizing an active conformer. In addition, a thermal shift assay suggested that the mutation was less able to bind vandetanib. Molecular dynamics simulation supported the mutant underwent conformational changes decreasing the binding affinity of vandetanib. Our findings indicate that the missense mutation is able to increase kinase activity and confers drug resistance through allosteric effects. Citation Format: Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Nino, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto. A secondary RET mutation allosterically conferring resistance to vandetanib [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 918.
Inhibition of Wnt‐2 and galectin‐3 synergistically destabilizes β‐catenin and induces apoptosis in human colorectal cancer cells (2007)

Constitutive activation of the Wnt pathway as a result of APC, AXIN1 or CTNNB1 mutations has been found in most colorectal cancers. For a long time, this aberrant Wnt activation has been thought to be independent of upstream signals. However, recent studies indicate that upstream signals retain their ability to regulate the Wnt pathway even in the presence of downstream mutations. Wnt-2 is well known for its overexpression in colorectal cancer. Galectin-3 (Gal-3), a multifunctional carbohydrate binding protein implicated in a variety of biological functions, has recently been reported to interact with beta-catenin. In this study, we investigated roles of Wnt-2 and Gal-3 in the regulation of canonical Wnt/beta-catenin signaling. We found that siRNA silencing of either Wnt-2 or Gal-3 expression inhibited TCF-reporter activity, decreased cytosolic beta-catenin level and induced apoptosis in human colorectal cancer cells containing downstream mutations. More interestingly, we showed that inhibition of both Wnt-2 and Gal-3 had synergistic effects on suppressing canonical Wnt signaling and inducing apoptosis, suggesting that aberrant canonical Wnt/beta-catenin signaling in colorectal cancer can be regulated at multiple levels. The combined inhibition of Wnt-2 and Gal-3 may be of superior therapeutic advantage to inhibition by either one of them, giving rise to a potential development of novel drugs for the targeted treatment of colorectal cancer.
Content Adaptive Wavelet Lifting for Scalable Lossless Video Coding (2023)

Scalable lossless video coding is an important aspect for many professional applications. Wavelet-based video coding decomposes an input sequence into a lowpass and a highpass subband by filtering along the temporal axis. The lowpass subband can be used for previewing purposes, while the highpass subband provides the residual content for lossless reconstruction of the original sequence. The recursive application of the wavelet transform to the lowpass subband of the previous stage yields coarser temporal resolutions of the input sequence. This allows for lower bit rates, but also affects the visual quality of the lowpass subband. So far, the number of total decomposition levels is determined for the entire input sequence in advance. However, if the motion in the video sequence is strong or if abrupt scene changes occur, a further decomposition leads to a low-quality lowpass subband. Therefore, we propose a content adaptive wavelet transform, which locally adapts the depth of the decomposition to the content of the input sequence. Thereby, the visual quality of the low-pass subband is increased by up to 10.28 dB compared to a uniform wavelet transform with the same number of total decomposition levels, while the required rate is reduced by 1.06% additionally.
<title>High-density magneto-optical recording with magnetic field modulation and pulsed laser irradiation</title> (1990)

We have developed high density overwriting of a magneto-optical disk. A sharp pit-edge recording is achieved by a newly developed magnetic head and pulsed laser irradiation.
Identification of Triazolopyridines as Selective α5-GABAA Receptor Negative Allosteric Modulators by a Hybridization Approach (2022)

The identification and characterization of novel triazolopyridine derivatives with selective α5 subunit-containing GABA<sub>A</sub> receptor negative allosteric modulator (NAM) activity are disclosed. As a result of <i>in silico</i> screening of our corporate compound deck, we identified a moderately potent hit that was converted to an advanced hit bearing better physicochemical and pharmacological properties using a hybridization approach. Subsequent optimization led to the identification of <i>in vitro</i> potent and subtype-selective α5-GABA<sub>A</sub> receptor NAMs representing a new chemotype in this area.
A Critical Review of Cyclosporine Therapy in Inflammatory Bowel Disease (1995)

Cyclosporine A (CsA) is a potent inhibitor of cell-mediated immunity. Controlled trials in Crohn's disease with low-dose CsA (≤5 mg/kg/day) did not show efficacy for either chronically active inflammatory disease or for maintenance of remission. Uncontrolled trials of high-dose CsA (≥ 5 mg/kg/day oral or 4 mg/kg/day i.v.) suggest efficacy for both inflammatory and fistulous Crohn's disease. Both uncontrolled trials and one controlled study suggest that high-dose CsA is efficacious for severe ulcerative colitis (UC). A controlled trial of low-dose CsA enemas for left-sided UC did not show efficacy. There is a significant theoretical risk of irreversible CsA-associated nephropathy following treatment of inflammatory bowel disease (IBD) with high-dose CsA. Severe infectious complications may also occur rarely. It appears that CsA must be used at relatively high (and potentially toxic) dosages to achieve efficacy in IBD. Future studies should evaluate the efficacy and safety of the short-term use of high-dose CsA as “rescue therapy” in severe inflammatory Crohn's disease and UC, as well as in fistulous Crohn's disease.
Fluconazole and itraconazole susceptibility ofclinical isolates of Cryptococcus neoformans at a tertiary care centre in India: a need for care (2003)

The observed MIC data warrant continued surveillance of susceptibility values of clinical cryptococcal isolates in India.