gebhart/patrepeval huggingface dataset:
A lensed fiber Bragg grating-based membrane-in-the-middle optomechanical cavity (2022)

Abstract Optomechanical systems benefit from the coupling between an optical field and mechanical vibrations. Fiber-based devices are well suited to easily exploit this interaction. We report an alternative approach of a silicon nitride membrane-in-the-middle of a high quality factor ( $$10^6$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mn>10</mml:mn> <mml:mn>6</mml:mn> </mml:msup> </mml:math> – $$10^7$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mn>10</mml:mn> <mml:mn>7</mml:mn> </mml:msup> </mml:math> ) Fabry–Perot, formed by a grating inscribed within a fiber core as an input mirror in front of a dielectric back mirror. The Pound–Drever–Hall technique used to stabilize the laser frequency on the optical resonance frequency allows us to reduce the low frequency noise down to $${4}\,{{\mathrm{kHz}}/\sqrt{\mathrm{Hz}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>4</mml:mn> <mml:mspace/> <mml:mrow> <mml:mi>kHz</mml:mi> <mml:mo>/</mml:mo> <mml:msqrt> <mml:mi>Hz</mml:mi> </mml:msqrt> </mml:mrow> </mml:mrow> </mml:math> . We present a detailed methodology for the characterization of the optical and optomechanical properties of this stabilized system, using various membrane geometries, with corresponding resonance frequencies in the range of several hundred of $${\mathrm{kHz}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>kHz</mml:mi> </mml:math> . The excellent long-term stability is illustrated by continuous measurements of the thermomechanical noise spectrum over several days, with the laser source maintained at optical resonance. This major result makes this system an ideal candidate for optomechanical sensing.
Improved Robust TOA-Based Localization via NLOS Balancing Parameter Estimation (2019)

In this paper, the time-of-arrival-based localization problem under mixed line-of-sight/non-line-of-sight (LOS/NLOS) conditions is addressed. Previous studies show that existing robust methods perform well in dense NLOS environments, but generally perform badly in sparse NLOS environments. To alleviate this problem, we introduce a “balancing parameter” related to the NLOS errors and formulate a new robust weighted least squares (RWLS) problem with the source position and the NLOS balancing parameter as the estimation variables. The proposed method does not require the statistics of NLOS errors and the path status. By leveraging the S-Lemma, the RWLS problem is transformed into a non-convex optimization problem, which is then relaxed into a convex semidefinite program. Simulation results show that the proposed method works well for both the sparse and dense NLOS environments.
Incorporating Uncertainty into Deep Learning for Spoken Language Assessment (2017)

There is a growing demand for automatic assessment of spoken English proficiency. These systems need to handle large variations in input data owing to the wide range of candidate skill levels and L1s, and errors from ASR. Some candidates will be a poor match to the training data set, undermining the validity of the predicted grade. For high stakes tests it is essential for such systems not only to grade well, but also to provide a measure of their uncertainty in their predictions, enabling rejection to human graders. Previous work examined Gaussian Process (GP) graders which, though successful, do not scale well with large data sets. Deep Neural Networks (DNN) may also be used to provide uncertainty using Monte-Carlo Dropout (MCD). This paper proposes a novel method to yield uncertainty and compares it to GPs and DNNs with MCD. The proposed approach explicitly teaches a DNN to have low uncertainty on training data and high uncertainty on generated artificial data. On experiments conducted on data from the Business Language Testing Service (BULATS), the proposed approach is found to outperform GPs and DNNs with MCD in uncertainty-based rejection whilst achieving comparable grading performance.
Appearance capturing and animation techniques for realistic, true-identity gaming avatars (2009)

Making use of a class of 2D statistical face models known as active appearance models (AAMs), we investigate a technique for generating real-time animated avatars suitable for video gaming. We consider here a number of improvements of these models in order to make them more robust to varying environmental conditions, as well as to reduce the computational load such that to become adapted for real-time implementations.
Data from Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;G100 is a toll-like receptor 4 (TLR4) agonist that triggers innate and adaptive antitumor immune responses in preclinical models. This pilot study assessed the safety, efficacy, and immunologic activity of intratumoral (IT) administration of G100 in patients with Merkel cell carcinoma (MCC).&lt;/p&gt;Patients and Methods:&lt;p&gt;Patients with locoregional MCC (&lt;i&gt;n&lt;/i&gt; = 3; cohort A) received neoadjuvant IT G100 (2 weekly doses at 5 μg/dose) followed by surgery and radiotherapy; patients with metastatic MCC (&lt;i&gt;n&lt;/i&gt; = 7; cohort B) received 3 doses in a 6-week cycle and could receive additional cycles with/without radiotherapy.&lt;/p&gt;Results:&lt;p&gt;IT G100 was safe and feasible in both neoadjuvant and metastatic settings. Treatment-related adverse events were mostly grade 1 or 2 injection-site reactions. IT G100 led to increased inflammation in the injected tumors with infiltration of CD8&lt;sup&gt;+&lt;/sup&gt; and CD4&lt;sup&gt;+&lt;/sup&gt; T cells and activation of immune-related genes. These proinflammatory changes were associated with local tumor regression and appeared to promote systemic immunity. All 3 cohort A patients successfully completed therapy; 2 patients remain recurrence free at 44+ and 41+ months, including 1 with a pathologic complete response after G100 alone. In cohort B, 2 patients achieved sustained partial responses, both lasting 33+ months after 2 cycles of therapy.&lt;/p&gt;Conclusions:&lt;p&gt;In this first-in-human study, IT G100 induced antitumor immune responses, demonstrated acceptable safety, and showed encouraging clinical activity.&lt;/p&gt;&lt;p&gt;See related commentary by Marquez-Rodas et al., p. 1127&lt;/p&gt;&lt;/div&gt;
Identification of electronic state in perovskiteCaCrO3by high-pressure studies (2015)

$\mathrm{CaCr}{\mathrm{O}}_{3}$ is at the crossover from localized to itinerant electronic behavior, and interpretation of its electronic state has remained controversial. It is a metal from an optical study. However, the collinear type-C antiferromagnetic spin ordering below ${T}_{N}\ensuremath{\approx}\phantom{\rule{0.16em}{0ex}}90\phantom{\rule{0.16em}{0ex}}\mathrm{K}$ is characteristic of localized electron magnetism. We have performed many runs of high-pressure synthesis. $\mathrm{CaCr}{\mathrm{O}}_{3}$ crystals can be found in some batches. We have used specific-heat measurement as a diagnostic tool to probe the electronic states near the Fermi energy. An electronic bandwidth is broadened by applying high pressure. The magnetization measurement under pressure reveals a $d{T}_{N}/dP&lt;0$. The crystal structural change corresponding to the pressure-induced electron structural change has been monitored by in situ neutron diffraction under high pressure. The ${t}_{2}^{2}$ d-electron configuration on octahedral site $\mathrm{C}{\mathrm{r}}^{4+}$ is orbitally threefold degenerate. Local site distortions are argued to show that in $\mathrm{CaCr}{\mathrm{O}}_{3}$ the crossover from localized to itinerant 3d electrons does not result in a charge-density wave in which segregation of the interatomic interactions results in the stabilization of molecular clusters, but in an intraatomic orbital ordering that stabilizes a half-filled localized-electron $xy$ orbital and a $1/4$-filled $c$-axis ${\ensuremath{\pi}}^{*}$ band. Local structural changes under pressure reveal a weakening of long-range magnetic order is associated with a smooth Mott-Hubbard transition of the $xy$ electrons.
Cell-Free Massive MIMO with Radio Stripes for Indoor Wireless Energy Transfer. (2021)

Radio frequency wireless energy transfer (WET) is a promising solution for powering autonomous IoT deployments. Recent works on WET have mainly focused on extremely low-power/cost IoT applications. However, trending technologies such as energy beamforming and waveform optimization, distributed and massive antenna systems, smart reflect arrays and reconfigurable metasurfaces, flexible energy transmitters, and mobile edge computing, may broaden WET applicability, and turn it plausible for powering more energy-hungry IoT devices. In this work, we specifically leverage energy beamforming for powering multiple user equipments (UEs) with stringent energy harvesting (EH) demands in an indoor cell-free massive MIMO. Based on semi-definite programming, successive convex approximation (SCA), and maximum ratio transmission (MRT) techniques, we derive optimal and sub-optimal precoders aimed at minimizing the radio stripes' transmit power while exploiting information of the power transfer efficiency of the EH circuits at the UEs. Moreover, we propose an analytical framework to assess and control the electromagnetic field (EMF) radiation exposure in the considered indoor scenario. Numerical results show that i) the EMF radiation exposure can be more easily controlled at higher frequencies at the cost of a higher transmit power consumption, ii) training is not a very critical factor for the considered indoor system, iii) MRT/SCA-based precoders are particularly appealing when serving a small number of UEs, thus, specially suitable for implementation in a time domain multiple access (TDMA) scheduling framework, and iv) TDMA is more efficient than spatial domain multiple access (SDMA) when serving a relatively small number of UEs. Results suggest that additional boosting performance strategies are needed to increase the overall system efficiency, thus making the technology viable in practice.
First-in-human study of FLX925, an orally administered FLT3/CDK4/CDK6 inhibitor, in subjects with relapsed or refractory acute myeloid leukemia (AML). (2015)

TPS7098 Background: Acquired mutations in oncogenic kinases remains an obstacle between valid therapeutic hypotheses and meaningful patient benefit. The inhibition of FLT3 can be efficacious in AML patients, particularly in FLT3-ITD mutated cancers. However, relapse is common and frequently associated with the acquisition of secondary resistance mutations in FLT3. FLX925 is a next-generation kinase inhibitor that was prospectively designed to address or avoid common mechanisms of resistance to earlier FLT3 inhibitors, with its unique binding mode and potent activity against CDK4/CDK6 (Keegan et al, Mol Cancer Ther, 2014). FLX925 retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 that occur with quizartinib or sorafenib treatment. In addition, FLX925 potently inhibits CDK4/CDK6, central components of the cell cycle machinery. This unique profile may reduce the emergence of resistant clones and extend the therapeutic potential of FLX925 to other malignancies dependent on these pathways (e.g., MCL). These data suggest the unique profile of FLX925 makes it an ideal inhibitor for the treatment of cancers driven by FLT3 signaling, such as AML. Methods: This open label, sequential-group, dose escalation and cohort expansion study includes adult patients diagnosed with relapsed or refractory AML. Eligible patients need to have failed prior induction therapy or relapsed within 12 months of prior therapy. During cohort expansion, at the RP2D, patients will be enrolled into 3 cohorts: subjects with a FLT3 ITD or kinase domain mutation with (Cohort A) or without (Cohort B) prior FLT3 inhibitor treatment, or patients without a FLT3 mutation at screening (Cohort C). The primary objectives of the study are to characterize the safety and tolerability of twice-daily, oral FLX925. Key secondary objectives are to evaluate the pharmacokinetic (PK) profile, pharmacodynamics (PD) effects, and the magnitude and duration of antitumor activity with FLX925, using standard criteria. A Simon 2-stage mini-max approach will be used to test the null hypothesis based on the CRc rate. This trial (NCT02335814) is currently enrolling patients. Clinical trial information: NCT02335814.
Optimal caching of encoded data for content distribution in vehicular networks (2015)

Vehicular communications have gained momentum as a means to coordinate vehicular traffic by disseminating information about the road status and traffic conditions. However, over the time, vehicular applications have changed towards being driven by exchanging and accessing multimedia information. Such applications have therefore evolved and become very greedy in terms of transmitted traffic and used bandwidth. In this paper, we introduce a dynamic data placement scheme to improve data dissemination in vehicular networks. We highlight that, while the cost of storage memory decline over the years, storing all files in all Road Side Units results in a inefficient use of network resources. Our work selects only a subset of Road Side Units to store coded pieces of data that are later made available to all vehicles through the network. We formulate the data placement as an optimization problem to minimize the delivery time between each vehicle and the Road Side Units. Our experiments show that optimally placing coded data in the network greatly improves the network performance of existing VANET file swarming protocols.
Single-component light-emitting electrochemical cell fabricated from cationic polyfluorene: Effect of film morphology on device performance (2005)

Planar light-emitting electrochemical cells (LECs) were prepared by drop casting the conjugated polyelectrolyte poly(9,9-bis[6′-(N,N,N,-trimethylammonium)hexyl]fluorene-co-alt-1,4-phenylene) bromide (PFN+Br−) onto substrates patterned with micrometer-sized interelectrode (Au) gaps. When operated at room temperature (RT), such LECs exhibit a gap-size-dependent turn-on voltage for light emission, but when operated at 140°C, the turn-on voltage is essentially gap-size independent and close to the band gap of PFN+Br−. This temperature dependence is consistent with operation below and above the melting temperature (Tm=130°C) of PFN+Br− and is consequently a signature of anion mobility. The RT morphology of PFN+Br− is dependent on the film preparation process: slow evaporation of the solvent via drop casting produces a partially crystalline film, while a fast evaporation via spin casting produces a glassy film. The glassy spin-cast film can, however, be transformed into a partially crystalline film by slow cooling (0.5°C∕min) from an elevated temperature (180°C) to RT. The photoluminescence (PL) from a partially crystalline film is slightly blueshifted and its vibronic structure better resolved than the PL from a glassy spin-cast film.
Table S1 from Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma (2023)

&lt;p&gt;Table S1 describes patient characteristics by clinical response to treatment&lt;/p&gt;
Immunotherapy in Secondary and Light‐Chain Amyloidosis (2010)

This chapter contains sections titled: Introduction Immunotherapy for Amyloid Diseases Antigens for Immunotherapy of AL and AA Preclinical Immunotherapy for AA and AL Amyloidosis Prospects and Problems with Immunotherapy for Peripheral Amyloidoses References
Spatial spectrum holes for cognitive radio with relay-assisted directional transmission (2009)

Spectrum hole (SH) is defined as a spectrum band that can be utilized by unlicensed users, which is a basic resource for cognitive radio (CR) systems. Most of existing contributions detect SHs by sensing whether a primary signal is present or absent and then try to access them so that the CR and primary users use the spectrum band either at different time slots or in different geographic regions. In this paper, we propose a novel scheme with relays or directional relays for CR users to exploit new spectrum opportunity, called spatial SH. It can provide higher spectrum efficiency by coexistence of primary and CR users at the same region, time, and spectrum band. In particular, when the spectrum opportunity of a direct link from a CR transmitter to a CR receiver does not appear, our scheme may still establish the communication through indirect links, i.e., other CR users act as relay stations to assist the communication by using other spatial domains. Furthermore, we analyze the successful communication probabilities of CR users and demonstrate that the spectrum efficiency can be considerably improved by our scheme.
Parameterized Dataflow Scenarios (2016)

A number of modeling approaches combining dataflow and finite-state machines (FSMs) have been proposed to capture applications that combine streaming data with finite control. FSM-based scenario-aware dataflow (FSM-SADF) is such an FSM/dataflow hybrid that occupies a sweet spot in the tradeoff between analyzability and expressiveness. However, the model suffers from compactness issues when the number of scenarios increases. This hampers its use in analysis of applications exposing high levels of data-dependent dynamics. In this paper, we address this problem by combining parameterized dataflow with finite control of FSM-SADF. We refer to the generalization as FSM-based parameterized SADF (FSM-πSADF). We introduce the formal semantics of the model, in terms of maxplus algebra and in particular max-plus automata. Thereafter, by leveraging the existing results of FSM-SADF, we propose a worst-case performance analysis framework for FSM-πSADF. We show that by using FSM-πSADF and its analysis framework, one can, unlike with FSM-SADF, compactly capture streaming applications exhibiting high levels of data-dependent dynamics in presence of finite control. Furthermore, we show that for practical models our analysis typically yields tighter bounds on worst-case performance indicators such as throughput and latency than the existing techniques based on conservative FSM-SADF modeling (if such modeling can be applied at all). We evaluate our approach on a realistic case-study from the multimedia domain.
SE3: Favorite Circuit Design and Testing Mistakes of Starting Engineers (2021)

This special event will focus on typical mistakes that all starting graduate students seem to make when they first start designing circuits. Many of these errors are simple and easily avoided if only they are pre-warned. These errors show up at different phases of design, simulation, layout and testing. Renowned speakers will share their experience and provide examples of their own mistakes!
Effect of a magnetic field on the luminescent lifetime ofCu+in alkali halide host crystals (1984)

We have measured the change in the triplet emission lifetime of the ${\mathrm{Cu}}^{+}$ impurity in various alkali halide hosts at 4.2 K as a function of applied magnetic field. Pedrini [Phys. Status Solidi B 87, 273 (1978)] has proposed that the $^{3}E_{g}$ emitting state is split into ${T}_{1g}$ and ${T}_{2g}$ spin-orbit components and has found that the emission lifetime depends sensitively on the splitting. We have utilized an external magnetic field to mix these spin-orbit levels. This produced a measurable decrease in the emission lifetime which we explained with Pedrini's model. We also diagonalized the ${d}^{9}s$ excited-state matrix to calculate independently the ${T}_{1g}$,${T}_{2g}$ spin-orbit splitting and obtained reasonable agreement with our experimental results.
Supplementary Methods, Figures 1 -2 from Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity (2023)

&lt;p&gt;Supplementary Materials and Methods. Supplementary Figure S1: Cell viability in various concentrations of DNA-damaging agents and novel ATR pathway inhibitors. Supplementary Figure S2: Effects of novel and established ATR pathway inhibitors on Chk1 phosphorylation induced by hydroxyurea or cisplatin as assessed by flow cytometry.&lt;/p&gt;
Screening Test for Insecticides Interfering with Cuticular Sclerotization (1996)

The potential of known and new insecticides to interfere with cuticle sclerotization was investigated using assays for key enzymes such as phenoloxidase, quinone methide isomerase and DOPA decarboxylase. Homogenates from the blowfly Lucilia cuprina and from the epithelial cell line from Chironomus tentans were used to examine the compounds under investigation. Phenoloxidases are known to oxidize DOPA, the substrate for DOPA decarboxylase. Since phenoloxidases were not detectable in C. tentans cell homogenates, inhibitor and kinetic studies were done for comparison with DOPA decarboxylase of this insect cell line. DOPA decarboxylase and phenoloxidase of L. cuprina exerted highest specific activities at early pupal stages (day 7). The apparent Km values for the two enzymes were 0·47(±0·21) mM and 0·71(±0·16) mM, respectively, using L-DOPA as substrate. DOPA decarboxylase from C. tentans had a Km value of 0·42(±0·18) mM. Quinone methide isomerase was most active in young pupae. In terms of substrate specificity for enzymic (mushroom-tyrosinase) production of different quinones from their corresponding catechols, that with dopamine quinone proved to be the most efficient. Synthesis of derivatives of L-DOPA and L-tyrosine led to a compound which inhibited both phenoloxidase and quinone methide isomerase. DOPA decarboxylase from L. cuprina and from cells of C. tentans was inhibited by carbidopa (IC50 values of 0·021(±0·011) μM and 0·031(±0·019) μM, respectively) and indomethacine (IC50 values of 22·6(±7·1) μM and 18·8(±9·7) μM). Both compounds exerted a competitive type of inhibition and were able to interfere with development of L. cuprina.
Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019)

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [103]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [146, 305, 213, 55], agonist-bound [362, 196, 198] and G protein-bound A2A adenosine receptors [43] have been described. The structures of an antagonist-bound A1 receptor [123] and an adenosine-bound A1 receptor-Gi complex [80] have been resolved by cryo-electronmicroscopy. Another structure of an antagonist-bound A1 receptor obtained with X-ray crystallography has also been reported [51].
3′‐Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis (2018)

3'-SL ameliorated pathogenesis of CIA by suppressing catabolic factor expression, proliferation of inflammatory immune cells and osteoclastogenesis. These effects were mediated via blockade of the NF-κB signalling pathway. Therefore, 3'-SL exerted prophylactic and therapeutic effects and could be a novel therapeutic agent for the treatment of RA.
Supplementary Table 2 from NOTCH Is Part of the Transcriptional Network Regulating Cell Growth and Survival in Mouse Plasmacytomas (2023)

Supplementary Table 2 from NOTCH Is Part of the Transcriptional Network Regulating Cell Growth and Survival in Mouse Plasmacytomas