gebhart/patrepeval huggingface dataset:
Dynamics of Uniaxially Oriented Elastomers Using Broadband Dielectric Spectroscopy (2010)

ADVERTISEMENT RETURN TO ISSUECommunication to the...Communication to the EditorNEXTDynamics of Uniaxially Oriented Elastomers Using Broadband Dielectric SpectroscopyHyungKi Lee†, Daniel Fragiadakis‡, Darren Martin§, Anthony Milne⊥, John Milne⊥, and James Runt*†View Author Information† Department of Materials Science and Engineering, Penn State University, University Park, Pennsylvania 16802‡ Naval Research Lab, Washington, D.C. 20375§ Australian Institute of Bioengineering & Nanotechnology, University of Queensland, St. Lucia, QLD 4072, Australia⊥ Milne Corp, Brisbane, QLD, Australia*To whom correspondence should be addressed. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 7, 3125–3127Publication Date (Web):March 11, 2010Publication History Received10 February 2010Revised9 March 2010Published online11 March 2010Published inissue 13 April 2010https://doi.org/10.1021/ma100340cCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views898Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (3 MB) Get e-AlertsSUBJECTS:Deformation,Elastomers,Insulators,Nucleic acid structure,Organic polymers Get e-Alerts
Effects of a dietary supplement on chronic pelvic pain syndrome (Category IIIA), leucocytospermia and semen parameters (2011)

Chronic prostatitis (CP) is one of the most common male urogenital diseases and a significant public health problem in industrialised countries. It is associated with a low quality of life and significant expense. Given the poor results achieved with antibiotics, scientific interest has turned to the use of natural substances with a known activity on prostate function. The aim of our study was to evaluate the effect of a new dietary supplement containing lycopene, epigallocatechin gallate, ellagic acid, selenium and zinc on semen parameters and on leucocyte concentration in seminal fluid and expressed prostate secretion (EPS) in patients with CP without infection [National Institute of Health (NIH) Category IIIA], in comparison with a control group with the same condition who did not undergo any treatment during the study period. Our data showed a statistically significant reduction in inflammatory parameters (leucocytes in seminal fluid and EPS) and a statistically significant improvement in progressive sperm motility and sperm morphology in patients treated with the supplement in comparison with the untreated group. Improvements were also seen in the pain score of the NIH-Chronic Prostatitis Symptom Index (CPSI), confirming that the reduced inflammation also resulted in a reduction in pain.
Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates (2016)

Disulfide bonds could be valuable linkers for a variety of therapeutic applications requiring tunable cleavage between two parts of a molecule (e.g., antibody-drug conjugates). The in vitro linker immolation of β-mercaptoethyl-carbamate disulfides and DNA alkylation properties of associated payloads were investigated to understand the determinant of cell killing potency of anti-CD22 linked pyrrolobenzodiazepine (PBD-dimer) conjugates. Efficient immolation and release of a PBD-dimer with strong DNA alkylation properties were observed following disulfide cleavage of methyl- and cyclobutyl-substituted disulfide linkers. However, the analogous cyclopropyl-containing linker did not immolate, and the associated thiol-containing product was a poor DNA alkylator. As predicted from these in vitro assessments, the related anti-CD22 ADCs showed different target-dependent cell killing activities in WSU-DLCL2 and BJAB cell lines. These results demonstrate how the in vitro immolation models can be used to help design efficacious ADCs.
Partial-contact head-disk interface approach for high-density recording (2005)

An isolated-pad-type slider and a narrow-trailing-edge-type slider were designed and fabricated for partial-contact head-disk interface. Evaluation results showed that friction reduction is the key point for a partial-contact interface. A small isolated pad slider exhibited reduced off-track vibration and less aggressive disk lubricant depletion. Moreover, drive tests of a narrower-trailing-edge slider showed that it has the advantage of easier transition from contact to flying.
Ambient occlusion via compressive visibility estimation (2015)

There has been emerging interest on recovering traditionally challenging intrinsic scene properties. In this paper, we present a novel computational imaging solution for recovering the ambient occlusion (AO) map of an object. AO measures how much light from all different directions can reach a surface point without being blocked by self-occlusions. Previous approaches either require obtaining highly accurate surface geometry or acquiring a large number of images. We adopt a compressive sensing framework that captures the object under strategically coded lighting directions. We show that this incident illumination field exhibits some unique properties suitable for AO recovery: every ray's contribution to the visibility function is binary while their distribution for AO measurement is sparse. This enables a sparsity-prior based solution for iteratively recovering the surface normal, the surface albedo, and the visibility function from a small number of images. To physically implement the scheme, we construct an encodable directional light source using the light field probe. Experiments on synthetic and real scenes show that our approach is both reliable and accurate with significantly reduced size of input.
Flux Calculation Using Metabolic Control Constraints (1998)

Prediction of metabolic fluxes requires the knowledge of reaction stoichiometry and the overall reaction kinetics including various regulatory mechanisms. Lacking the complete reaction kinetics, one often uses available flux measurements or other constraints to calculate the intracellular fluxes. In this article, we show that the flux constraints derived from the dynamic metabolic control theory can be used instead of the kinetics to calculate the fluxes. This approach provides a possibility of predicting the flux distribution in a genetically modified organism using the flux control coefficients and the fluxes determined from the host or the parent strains. It shows that the regulatory constraints can be expressed in terms of the flux control coefficients. This result gives new significance to the flux control coefficients and provides new incentives to determine the flux control coefficients systematically.
EVALUATION OF CATHODIC PROTECTION SYSTEMS FOR MARINE BRIDGE SUBSTRUCTURES (1998)

Four different cathodic protection systems were installed and evaluated in the reinforced concrete tie beams and footings of four bents at the Queen Isabella Causeway which links South Padre Island to the mainland of Texas. The types of cathodic protection systems installed and evaluated were impressed current sprayed zinc, sprayed titanium, titanium mesh with overlay and sacrificial sprayed zinc. The primary objectives of this study were to monitor and evaluate the installation of the different cathodic protection systems, to evaluate performance of the cathodic protection systems, to establish recommendations for full-scale application of cathodic protection for the Queen Isabella Causeway and to establish recommendations for the implementation of cathodic protection systems for marine bridge substructures in Texas. As part of this study, a pre-installation condition evaluation for the Queen Isabella Causeway was conducted. The purpose of the pre-installation evaluation was to assess the condition of the structure and the feasibility of cathodic protection as a rehabilitation option. The installation of the different cathodic protection systems was described, and the installation of the anode systems was evaluated using constructability, productivity, safety and environmental concerns, and aesthetics as the evaluation parameters. The preliminary performance of the cathodic protection systems was evaluated through field and remote monitoring. The field monitoring evaluations comprised visual inspection, delamination survey, half-cell potential measurements, corrosion rate measurements, chloride content determination, concrete permeability determination, rectifier and system component evaluation and polarization decay testing. As part of the performance evaluation, the variability of the sacrificial sprayed zinc system was studied with the remote monitoring capability. A simplified cost analysis was performed for the installed cathodic protection systems, which consisted in calculating the equivalent annual installation costs for a range of anode service lives. On the basis of the pre-installation condition evaluation, the field installation, the performance and the cost analysis, a cathodic protection system type was recommended for the Queen Isabella Causeway. Guidelines for the design, installation, monitoring and maintenance of the recommended system were provided as well as recommendations for the implementation of cathodic protection for marine bridge substructures in Texas.
Bright Building Blocks for Chemical Biology (2014)

Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol. 2008, 3, 142-155), the extant collection of fluorescent probes is built on a modest set of "core" scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists.
Data from Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[<sup>18</sup>F]Fluorothymidine in Preclinical Models of Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;3′-Deoxy-3′-[&lt;sup&gt;18&lt;/sup&gt;F]fluorothymidine positron emission tomography ([&lt;sup&gt;18&lt;/sup&gt;F]FLT-PET) and diffusion-weighted MRI (DW-MRI) are promising approaches to monitor tumor therapy response. Here, we employed these two imaging modalities to evaluate the response of lung carcinoma xenografts in mice after gemcitabine therapy. Caliper measurements revealed that H1975 xenografts responded to gemcitabine treatment, whereas A549 growth was not affected. In both tumor models, uptake of [&lt;sup&gt;18&lt;/sup&gt;F]FLT was significantly reduced 6 hours after drug administration. On the basis of the gemcitabine concentration and [&lt;sup&gt;18&lt;/sup&gt;F]FLT excretion measured, this was presumably related to a direct competition of gemcitabine with the radiotracer for cellular uptake. On day 1 after therapy, [&lt;sup&gt;18&lt;/sup&gt;F]FLT uptake was increased in both models, which was correlated with thymidine kinase 1 (TK1) expression. Two and 3 days after drug administration, [&lt;sup&gt;18&lt;/sup&gt;F]FLT uptake as well as TK1 and Ki67 expression were unchanged. A reduction in [&lt;sup&gt;18&lt;/sup&gt;F]FLT in the responsive H1975 xenografts could only be noted on day 5 of therapy. Changes in ADC&lt;sub&gt;mean&lt;/sub&gt; in A549 xenografts 1 or 2 days after gemcitabine did not seem to be of therapy-related biological relevance as they were not related to cell death (assessed by caspase-3 IHC and cellular density) or tumor therapy response. Taken together, in these models, early changes of [&lt;sup&gt;18&lt;/sup&gt;F]FLT uptake in tumors reflected mechanisms, such as competing gemcitabine uptake or gemcitabine-induced thymidylate synthase inhibition, and only reflected growth-inhibitory effects at a later time point. Hence, the time point for [&lt;sup&gt;18&lt;/sup&gt;F]FLT-PET imaging of tumor response to gemcitabine is of crucial importance. &lt;i&gt;Cancer Res; 76(24); 7096–105. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Microdialysis Monitoring of Liver Grafts by Metabolic Parameters, Cytokine Production, and Complement Activation (2008)

Microdialysis using a 100-kDa filter is a promising way of monitoring the inflammatory reaction after liver transplantation. Increase in IP-10 reflects a normal pathophysiologic response posttransplant, whereas IL-8 and C5a were increased only in patients with rejection.
Letter: which patients with hepatitis B virus‐related hepatocellular carcinoma should receive nucleos(t)ide analogue therapy? Authors' reply (2016)

We thank Liao et al. for their interest in our work.1 Our conclusion that treatment with nucleos(t)ide analogues (NAs) reduces the risk of hepatocellular carcinoma (HCC) recurrence only refers to chronic hepatitis B patients treated by surgical resection.2 In contrast, the benefits in patients treated by other modalities – namely local ablative therapy, transarterial chemoembolisation or their combinations – did not reach statistical significance. The same applies to mortality.2 Liao et al. correctly pointed out that NA treatment has less impact on the outcome of patients with advanced HCC. This is because the prognosis depends heavily on tumour characteristics rather than viral factors. Even in early stage HCC, some clinical parameters other than viral load, e.g. prognostic nutritional index and albumin-to-alkaline phosphatase ratio, have strong influence on patient survival.3, 4 Therefore, it is well proven that anti-viral treatment with even a potent NA only reduces but does not eliminate HCC occurrence and recurrence.5, 6 Recent data showed that statins may further reduce the risk of HCC in NA-treated patients.7 Early results suggest that statin may also prevent HCC recurrence after liver resection, but more data are needed.8 We concur with Liao et al. that we should follow the current treatment guideline to offer NA treatment for patients with serum HBV DNA levels >2000 IU/mL. The benefits of NA treatment in HCC patients treated by surgical resection are beyond doubt.9 More data are still warranted to elucidate the role of NA treatment in patients with advanced HCC. The authors' declarations of personal and funding interests are unchanged from those in the original article.2
Refractory Metal Coated Alumina Foams as Support Material for Stem Cell and Fibroblasts Cultivation (2021)

Ceramics are widely used as implant materials; however, they are brittle and may emit particles when used in these applications. To overcome this disadvantage, alumina foams, which represent a 3D cellular structure comparable to that of human trabecular bone structures, were sputter coated with platinum, tantalum or titanium and modified with fibronectin or collagen type I, components of the extracellular matrix (ECM). To proof the cell material interaction, the unmodified and modified materials were cultured with (a) mesenchymal stem cells being a perfect indicator for biocompatibility and releasing important cytokines of the stem cell niche and (b) with fibroblasts characterized as mediators of inflammation and therefore an important cellular component of the foreign body reaction and inflammation after implantation. To optimize and compare the influence of metal surfaces on cellular behavior, planar glass substrates have been used. Identified biocompatible metal surface of platinum, titanium and tantalum were sputtered on ceramic foams modified with the above-mentioned ECM components to investigate cellular behavior in a 3D environment. The cellular alumina support was characterized with respect to its cellular/porous structure and niche accessibility and coating thickness of the refractory metals; the average cell size was 2.3 mm, the average size of the cell windows was 1.8 mm, and the total foam porosity was 91.4%. The Pt, Ti and Ta coatings were completely dense covering the entire alumina foam surface. The metals titanium and tantalum were colonized very well by the stem cells without a coating of ECM components, whereas the fibroblasts preferred components of the ECM on the alumina foam surface.
The imaginary planes method for the calculation of radiative heat transfer in industrial furnaces (1989)

Abstract Radiation is usually the dominant mode of heat transfer in furnace enclosures. The imaginary planes method is one of the new methods for calculating the radiative heat transfer in such systems. In this study, a general procedure was developed for its application in furnace modelling. Various case studies were carried out for a number of furnaces, and the results were compared with those of the zone method. It was found that the new method combines good accuracy with low computation time and appears to be a promising method for the determination of heat flux and temperature distributions within furnace enclosures.
Adjuvant-carrying targeted Synthetic Vaccine Particles ( t SVP™) augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release (75.3) (2012)

Abstract Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and also by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions resulting in safety concerns. Here we show that co-delivery of an antigen encapsulated into synthetic polymer nanoparticles with TLR7/8 or TLR9 agonists results in a strong elevation of immune responses which does not involve systemic production of inflammatory cytokines. In contrast, antigen admixed with free TLR7/8 agonist leads to lower immunogenicity and to rapid induction of serum cytokines associated with toxicity and immune suppression (e.g., TNF-α and IL-6 levels are 50-200 times higher upon injection of free than of encapsulated TLR7/8 agonist). Conversely, local immune stimulation as seen by cellular infiltration of draining lymph nodes and by intranodal cytokine production was much more pronounced and persisted longer if particle-encapsulated TLR agonists were used. Moreover, particle encapsulation permitted the efficient utilization of immunostimulatory CpG sequences with an enzyme-labile phosphodiester backbone which are known to rapidly degrade in vivo. The strong local immune activation in lymph nodes which resulted in a marked augmentation of immunogenicity was achieved using a modular self-assembling polymer nanoparticle platform and was equally efficient whether antigen and adjuvant were encapsulated in a single particle or in two separate particles.
Simulation for an improvement of a down-scaled HEMP thruster (2015)

We present a computer model of a downscaled High Efficiency Multistage Plasma Thruster (HEMPT). The purpose of downscaling the HEMPT design is to reach the requirements of missions which have a need for low thrust (0.1...150 µN) and low noise (root of the noise spectral density ≤ 0.1 µN/√Hz). These are upcoming formation flying space missions like eLISA (evolved Laser Interferometer Space Antenna) or NGGM (Next Generation Gravity Mission). The aim of the here presented numerical simulations is to get an improved understanding of the thrusters physics especially in its downscaled configuration, in order to reach the design goals.
Information structures to control formation splitting and merging (2004)

This paper focuses on developing techniques and strategies for the analysis and design of sensor and network topologies required to achieve rigid formations of mobile autonomous agents for cooperative tasks. These strategies ensure minimum number of changes in the set of sensing and communication links between agents during splitting and merging operations. That is, in splitting, all the links between agents in the same post-split sub-formation are preserved and a minimum number of links are inserted into each post-split sub-formation to regain minimal rigidity. In merging, all the links in each pre-merged rigid sub-formation are preserved and a minimum number of links are inserted between sub-formations to create one single post-merged minimally rigid formation.
Tutorial on Nanobiophotonics (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Faris, "Tutorial on Nanobiophotonics," in Biomedical Optics, Technical Digest (CD) (Optica Publishing Group, 2006), paper SF1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Unifying conversational multimedia interfaces for accessing network services across communication devices (2002)

This paper investigates architecture and interface design issues in engineering conversational multimedia interfaces for accessing network-based services. In particular, we focus on the problem of providing conversation-capable multimodal, multimedia services that can be accessed from a variety of communication devices and environments (telephones, PDAs, desktops etc) with a "consistent" user experience. The goals are two-fold: (i) provisioning a standards-compliant architecture and (ii) designing interfaces that are adaptive to the access device characteristics. We use a directory assistance application that can be accessed from a telephone, kiosk, desktop or a PDA to illustrate architecture and interface design issues.
EXISTENCE AND UNIQUENESS OF THE SOLUTION TO THE EDGE PROBLEM IN A TWO-DIMENSIONAL REACTIVE BOUNDARY LAYER (1995)

We prove an existence and uniqueness theorem for the ordinary differential problem which characterizes the profiles of the different physical quantities at the edge of two-dimensional reactive boundary layer. The main difficulties to be circumvented are the nonlinearities due to the different thermodynamical functions involved in the reactive boundary layer equations and the degeneracy caused by the natural initial conditions, where the tangential velocity has to vanish. We conclude by making some mathematical considerations about the relations that exist between the reactive boundary layer equations and the corresponding equations which describe the boundary layer in chemical equilibrium.
LAMELLA DISINTEGRATION AT SHEET FORMING NOZZLES, ESTIMATES FOR DROP SIZES (2002)

Breakup of attenuating lamella is most often initiated by aerodynamic waves. At relatively low Weber numbers instability due to long waves is dominant. At higher Weber numbers short waves occur according to Senecal et al. with a wave growth rate independent of the sheet t hickness. The a uthors presented their r esults as a CPU model for fast moving sheets to p redict mean droplet sizes. Here, their equations are transformed into a non dimensional π-number r elationship allowing for a parametric study v alid in the general case. Drop sizes were measured with PDA and compared with theoretical predictions. Despite of f airly satisfactory correlations between experiment and theory questions about the breakup process still exist.