gebhart/patrepeval huggingface dataset:
Novel polyelectrolyte composites that yield polycationic electrode coatings with large ion exchange capacities and exceptionally high effective diffusion coefficients for incorporated counterions (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel polyelectrolyte composites that yield polycationic electrode coatings with large ion exchange capacities and exceptionally high effective diffusion coefficients for incorporated counterionsDonald D. Montgomery, Kiyotaka Shigehara, Eishun Tsuchida, and Fred C. AnsonCite this: J. Am. Chem. Soc. 1984, 106, 25, 7991–7993Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ja00337a068https://doi.org/10.1021/ja00337a068research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of Prevailing Insulin Regimens at Different Time Periods in Hospitalized Patients: A Real-World Experience from a Tertiary Hospital (2021)

BBI improved glycemic control in a more efficacious manner than a split-mixed insulin regimen without increasing the risk of hypoglycemia in a hospital setting.
Nonequilibrium condensates and lasers without inversion: Exciton-polariton lasers (1996)

We analyze elementary properties of exciton and polariton lasers --- devices that generate coherent optical and matter waves using final-state stimulation of exciton-phonon scattering. First we discuss the relation between the conditions for the onset of equilibrium and nonequilibrium excitonic condensates. Provided that the thermal de Broglie wavelength ${\ensuremath{\lambda}}_{\mathit{T}}$ exceeds the exciton Bohr radius ${\mathit{a}}_{\mathit{B}}$, an exciton laser operates without electronic population inversion. In contrast to previous proposals, this is a different type of laser without inversion which utilizes many-body coherences. When the excitonic character of the polariton branch vanishes, a polariton laser becomes indistinguishable from a photon laser. \textcopyright{} 1996 The American Physical Society.
Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy (2002)

The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator of treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention may be heterogeneous. The use of imaging could assist in delineating therapeutic-induced spatial heterogeneity within a tumor mass by providing information related to specific regions that are resistant or responsive to treatment. Largely untapped potential resides in exploratory methods such as diffusion MRI, which is a non-volumetric intravoxel measure of tumor response based upon water molecular mobility. Alterations in water mobility reflect changes in tissue structure at the cellular level. While the clinical utility of diffusion MRI for oncologic practice is still under active investigation, this overview on the use of diffusion MRI for the evaluation of brain tumors will serve to introduce how this approach may be applied in the future for the management of patients with solid tumors.
Study of Carrier Generation in Phthalocyanines by Time-Resolved Fluorescence (2002)

We have studied the influence of electric field on fluorescence in particles of photoconductive TiOPc (I), TiOPc (IV), HOGaPc, and x-H2Pc dispersed in a polymer matrix. Electric field induced quenching of both the integrated and time-resolved fluorescence were measured. Time-resolved fluorescence decays were analyzed by fitting the data to a sum of two exponentials, representing the fast and slow fluorescence components. For HOGaPc, TiOPc(I), and TiOPc (IV), the fast fluorescence component exhibits both amplitude and lifetime quenching. These results indicate that carrier generation in HOGaPc, TiOPc(I), and TiOPc (IV) originates from both relaxed and nonrelaxed intrinsic excited singlet states, while the trapped excitons do not lead to significant carrier production. In contrast, for x-H2Pc, significant amplitude quenching of the fast component is observed only at high field, and the trapped excitons are an important source of photogenerated carriers. This indicates that x-H2Pc possesses at least some bulk-sensitized photocarrier generation. All of the phthalocyanines studied exhibited a quadratic dependence of integrated fluorescence quenching on electric field, indicating the existence of a neutral carrier precursor state.
Progress in VECC Cryogenic Penning Ion Trap Development (2013)

The development of VECC Cryogenic Penning Ion trap has reached an advanced stage and the system would soon be commissioned. We shall present the development of several crucial cryogenic components such as cryogenic feedthrough and cryoelectronic components. Both the cryogenic feedthrough and cryoelectronic components like RC filter, switching circuit and low-noise amplifier are essential items for the successful commissioning of the cryogenic Penning trap system and their developments have been described here.
RadarSNN: A Resource Efficient Gesture Sensing System Based on mm-Wave Radar (2022)

Radar offers a promising modality for enabling gesture recognition, which is a simple and intuitive alternative to click and touch-based human–computer interface. In this article, we propose a spiking neural network (SNN)-based hand gesture recognition with frequency-modulated continuous-wave 60-GHz radar. As preprocessing, the 2-D fast Fourier transform (FFT) is performed across fast time and slow time to generate a video of range–Doppler maps, which are then processed to generate range spectrograms, Doppler spectrograms, and angle spectrograms. The spike trains are fed into an SNN to classify the gesture that has been performed. We demonstrate that with few neurons, SNNs can achieve recognition accuracies close to 99.50% comparable to their deep learning counterparts for eight dynamic gestures. Moreover, the proposed model size is 75 kB, which is substantially smaller compared to the state-of-the-art models making it memory efficient. We also demonstrate using tSNE plots that SNNs can operate with lower embedding dimensions, implying that we can realize SNN with a small compute and memory footprint.
A Review of Databases Used in Orthopaedic Surgery Research and an Analysis of Database Use in Arthroscopy: The Journal of Arthroscopic and Related Surgery (2016)

Level IV, systematic review of Level II through IV studies.
A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation (2022)

The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, or the therapeutic potential of isoform-specific targeting. To systematically compare the impact of individual catalytic functions of HDAC1, HDAC2 and HDAC3, we generated human HAP1 cell lines expressing catalytically inactive HDAC enzymes. Using this genetic toolbox we compare the effect of individual HDAC inhibition with the effects of class I specific inhibitors on cell viability, protein acetylation and gene expression. Individual inactivation of HDAC1 or HDAC2 has only mild effects on cell viability, while HDAC3 inactivation or loss results in DNA damage and apoptosis. Inactivation of HDAC1/HDAC2 led to increased acetylation of components of the COREST co-repressor complex, reduced deacetylase activity associated with this complex and derepression of neuronal genes. HDAC3 controls the acetylation of nuclear hormone receptor associated proteins and the expression of nuclear hormone receptor regulated genes. Acetylation of specific histone acetyltransferases and HDACs is sensitive to inactivation of HDAC1/HDAC2. Over a wide range of assays, we determined that in particular HDAC1 or HDAC2 catalytic inactivation mimics class I specific HDAC inhibitors. Importantly, we further demonstrate that catalytic inactivation of HDAC1 or HDAC2 sensitizes cells to specific cancer drugs. In summary, our systematic study revealed isoform-specific roles of HDAC1/2/3 catalytic functions. We suggest that targeted genetic inactivation of particular isoforms effectively mimics pharmacological HDAC inhibition allowing the identification of relevant HDACs as targets for therapeutic intervention.
Capillary responses to functional and pathological activations rely on the capillary states at rest (2023)

Brain capillaries play a crucial role in maintaining cellular viability and thus preventing neurodegeneration. The aim of this study was to characterize the brain capillary morphology at rest and during neural activation based on a big data analysis from three-dimensional microangiography. Neurovascular responses were measured using a genetic calcium sensor expressed in neurons and microangiography with two-photon microscopy, while neural acivity was modulated by stimulation of contralateral whiskers or by a seizure evoked by kainic acid. For whisker stimulation, 84% of the capillary sites showed no detectable diameter change. The remaining 10% and 6% were dilated and constricted, respectively. Significant differences were observed for capillaries in the diameter at rest between the locations of dilation and constriction. Even the seizures resulted in 44% of the capillaries having no detectable change in diameter, while 56% of the capillaries dilated. The extent of dilation was dependent on the diameter at rest. In conclusion, big data analysis on brain capillary morphology has identified at least two types of capillary states: capillaries with diameters that are relatively large at rest and stable over time regardless of neural activity and capillaries whose diameters are relatively small at rest and vary according to neural activity.
Femtocell power control by discrimination of indoor and outdoor users (2011)

Femtocells are usually deployed in an indoor environment to provide in-building coverage enhancements. However, femtocells get to provide services for not only indoor users but also outdoor users in vicinity. Without the knowledge from the femtocell of whether the serviced users are located indoor or outdoor, the outdoor users are likely to experience low Quality of Service (QoS) due to inefficient coverage management and power control from the femtocells. To resolve such problem, this paper provides a method of discriminating indoor and outdoor users in a simplified way. Also, based on such discrimination, a downlink power control scheme is provided. Through simulations, we show that the discrimination procedure achieves 97.48% of correct determination in environment with low shadowing effect, and 89.41% of correct determination with high shadowing effects. Also based on the proposed discrimination procedure, power control exploiting such information provides a 31.96% reduction of outage probability, and a 8dB performance gain for cell-edge HUEs, compared to a power control with random discrimination.
ChemInform Abstract: Two Glutaric Acid Derivatives from Olives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Energy-performance tunable logic (2009)

An externally static, internally dynamic topology creates a new logic family that enables the user to tune effective transistor thresholds post-fabrication by adjusting a few power supplies. These gates can therefore be programmed for higher speed or for lower power based on the system requirements. An application of this logic to programmable interconnect circuits is shown in this paper. In a 90-nm test chip, the circuit achieves the same performance as conventional static circuits at 65% energy and has a 2X wider energy-performance tuning range. This property enables building in-field energy-performance tunable FPGAs.
From City Streets to Metropolitan Scale in Paris and the Île-de-France Region (2018)

Since the 1990s, the city of Paris and Île-de-France region (ie Paris urban region and regional government) have experienced massive and profound changes in transportation policy. Officials in Paris City council, region Ile de France and other local authorities have combined initiatives and programs to expand public transport infrastructure and modify use of street space, promoting strong alternatives to private vehicle use and auto-centric urban design, and increasing accessibility to major economic and financial centers. How did Paris achieve these successes in transport policymaking? How did the city and region establish a new mobility paradigm? We argue that the political objectives, policy innovations, and institutionalized governance changes that connected city and regional actors together behind a more integrated transport system, highlighting the key role that conflict and cooperation among political authorities and parties at various scales played in achieving these transformative transportation outcomes.
Ethnically relevant consensus Korean reference genome towards personal reference genomes (2016)

Abstract Human genomes are routinely compared against a universal reference. However, this strategy could miss population-specific or personal genomic variations, which may be detected more efficiently using an ethnically-relevant and/or a personal reference. Here we report a hybrid assembly of Korean reference (KOREF) as a pilot case for constructing personal and ethnic references by combining sequencing and mapping methods. KOREF is also the first consensus variome reference, providing information on millions of variants from additional ethnically homogeneous personal genomes. We found that this ethnically-relevant consensus reference was beneficial for efficiently detecting variants. Systematic comparison of KOREF with previously established human assemblies showed the importance of assembly quality, suggesting the necessity of using new technologies to comprehensively map ethnic and personal genomic structure variations. In the era of large-scale population genome projects, the leveraging of ethnicity-specific genome assemblies as well as the human reference genome will accelerate mapping all human genome diversity.
Capitation Reimbursement for Pediatric Primary Care (1986)

A feasibility analysis of capitation reimbursement for a primarily Medicaid population in The Johns Hopkins Pediatric Primary Care Clinic was conducted. The utilization of all inpatient and outpatient care of 2,261 patients was monitored for a 6-month period. As a result, per capita rates based on charges were determined for each group of patients according to type of insurance. Blue Cross and private insurance patients had capitation rates three times that of the Medicaid patients and over ten times that of the self-pay patients. This variation in utilization was attributed to the selection of enrollees, the morbidity of the population, and the varying services covered by payor group. Administrative issues regarding establishing a pediatric health maintenance organization are also discussed. Close supervision of house staff in treating patients, including admissions, length of stay, and specialty referral is of utmost importance in containing costs in this clinic setting.
Temporal responses of wild-type pigmentation and RcaE-deficient strains of Fremyella diplosiphon during light transitions. (2011)

A temporal study was conducted to evaluate the dynamic complementary chromatic adaptation (CCA) response of two Fremyella diplosiphon strains-wild-type pigmentation strain SF33 and an RcaE-deficient (ΔrcaE) strain, which lacks the photosensor that regulates CCA. SF33 and ΔrcaE cultures were monitored for 15 days after transition of green-light (GL) acclimated cultures to red light (RL) and vice versa. SF33 showed similar growth irrespective of the external light quality; however, a ΔrcaE strain grew slower than SF33 under both RL and GL. Chlorophyll a (chla) content increased in both strains over time and was not much different under RL and GL indicating that chla biosynthesis is not affected significantly by light quality or RcaE function. Phycoerythrin is the sole pigment to absorb GL, whereas several pigments, i.e., allophycocyanin, phycocyanin and chla, function under RL to drive photosynthesis. SF33 compensates for this by synthesizing a higher percentage of PE under GL. The final pigment distribution in the ΔrcaE mutant was found to be more different from SF33 under GL than under RL indicating that RcaE is needed for a transitional response to RL and RL-dependent repression of PE accumulation, yet RcaE is virtually critical for both transitioning to and a full adaptation to GL.
Biomechanical Comparison of Anterior Versus Posterior Lumbar Threaded Interbody Fusion Cages (2005)

Both anterior lumbar interbody fixation and posterior lumbar interbody fixation provided inconsistent stability. Therefore, stand-alone anterior lumbar interbody fixation or posterior lumbar interbody fixation may often be ineffective clinically. During all modes of loading except axial rotation, posterior lumbar interbody fixation performed slightly better than anterior lumbar interbody fixation, perhaps due to deeper hole preparation and destruction of anterior stabilizers necessary for anterior lumbar interbody fixation. Avoiding resection of facets during posterior lumbar interbody fixation led to significantly better performance during axial rotation.
Lessons from a restricted Turing test (1994)

article Free Access Share on Lessons from a restricted Turing test Author: Stuart M. Shieber Harvard Univ., Cambridge, MA Harvard Univ., Cambridge, MAView Profile Authors Info & Claims Communications of the ACMVolume 37Issue 6June 1994 pp 70–78https://doi.org/10.1145/175208.175217Published:01 June 1994Publication History 77citation920DownloadsMetricsTotal Citations77Total Downloads920Last 12 Months40Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial (2019)

This study confirms the previously demonstrated safety of COR-1 in humans and indicates a potential for use of COR-1 as a therapy to reduce viral shedding in HSV-2 infected subjects.
Effect of Surface Free Energy on PDMS Transfer in Microcontact Printing and Its Application to ToF-SIMS to Probe Surface Energies (2009)

Although polydimethylsiloxane (PDMS) transfer during microcontact printing (microCP) has been observed in previous reports, which generally focused on only one or a few different substrates, in this work we investigate the extent of PDMS transfer onto a series of surfaces with a wide range of hydrophobicities using an uninked, unpatterned PDMS stamp. These surfaces include clean silicon, clean titanium, clean gold, "dirty" silicon, polystyrene, Teflon, surfaces modified with PEG, amino, dodecyl, and hexadecyl monolayers, and also two loose molecular materials. The PDMS transferred onto planar surfaces is, in general, easily detected by wetting and spectroscopic ellipsometry. More importantly, it is detected by time-of-flight secondary ion mass spectrometry (ToF-SIMS) because of the sensitivity of this technique to PDMS. The effect of surface free energy on PDMS transfer in microcontact printing is investigated, and the relationship between the amount of PDMS in ToF-SIMS spectra and the surface tensions of initial surfaces is revealed. We show that PDMS transfer can be applied as a probe of surface free energies using ToF-SIMS, where PDMS preferentially transfers onto more hydrophilic surface features during stamping, with little being transferred onto very hydrophobic surface features. Multivariate curve resolution (MCR) analysis of the ToF-SIMS image data further confirms and clarifies these results. Our data lend themselves to the hypothesis that it is the free energy of the surface that plays a major role in determining the degree of PDMS transfer during microCP.
Porphyrin Bleaching and PDT-induced Spectral Changes are Irradiance Dependent in ALA-sensitized Normal Rat Skin In Vivo¶ (2001)

Photobleaching kinetics of aminolevulinic acid-induced protoporphyrin IX (PpIX) were measured in the normal skin of rats in vivo using a technique in which fluorescence spectra were corrected for the effects of tissue optical properties in the emission spectral window through division by reflectance spectra acquired in the same geometry and wavelength interval and for changes in excitation wavelength optical properties using diffuse reflectance measured at the excitation wavelength. Loss of PpIX fluorescence was monitored during photodynamic therapy (PDT) performed using 514 nm irradiation. Bleaching in response to irradiances of 1, 5 and 100 mW cm-2 was evaluated. The results demonstrate an irradiance dependence to the rate of photobleaching vs irradiation fluence, with the lowest irradiance leading to the most efficient loss of fluorescence. The kinetics for the accumulation of the primary fluorescent photoproduct of PpIX also exhibit an irradiance dependence, with greater peak accumulation at higher irradiance. These findings are consistent with a predominantly oxygen-dependent photobleaching reaction mechanism in vivo, and they provide spectroscopic evidence that PDT delivered at low irradiance deposits greater photodynamic dose for a given irradiation fluence. We also observed an irradiance dependence to the appearance of a fluorescence emission peak near 620 nm, consistent with accumulation of uroporphyrin/coproporphyrin in response to mitochondrial damage.