gebhart/patrepeval huggingface dataset:
Multi-ported, internally recuperated burners for direct flame impingement heating applications (2023)

A direct flame impingement method and apparatus employing at least one multi-ported, internally recuperated burner. The burner includes an innermost coaxial conduit having a first fluid inlet end and a first fluid outlet end, an outermost coaxial conduit disposed around the innermost coaxial conduit and having a combustion products outlet end proximate the first fluid inlet end of the innermost coaxial conduit and a combustion products inlet end proximate the first fluid outlet end of the innermost coaxial conduit, and a coaxial intermediate conduit disposed between the innermost coaxial conduit and the outermost coaxial conduit, whereby a second fluid annular region is formed between the innermost coaxial conduit and the intermediate coaxial conduit and a combustion products annular region is formed between the intermediate coaxial conduit and the outermost coaxial conduit. The intermediate coaxial conduit has a second fluid inlet end proximate the first fluid inlet end of the innermost coaxial conduit and a second fluid outlet end proximate the combustion products inlet end of the outermost coaxial conduit.
Glossary (2002)

Process of taking in. Chemicals can be absorbed into the bloodstream after breathing or swallowing.
Temsirolimus for the treatment of mantle cell lymphoma (2009)

Although recent progress has been made in the treatment of mantle cell lymphoma (MCL) the majority of patients experience relapse and ultimately die of their disease. The translocation t(11;14) is a prerequisite for the diagnosis of MCL and results in overexpression of cyclin D1. Its protein translation is controlled by mTOR, a key element of the PI3K/Akt pathway, and mTOR constitutes an attractive therapeutic target. Temsirolimus, a specific inhibitor of mTOR, has been evaluated in two Phase II trials in patients with relapsed MCL, and promising response rates up to 40% were found. Subsequently, a randomized Phase III trial was initiated, in which superiority in remission induction and progression-free survival could be demonstrated for a regimen of temsirolimus 175 mg for 3 weeks, followed by a 75-mg weekly application in comparison with established agents. This adds temsirolimus to the therapeutic armamentarium for the treatment of MCL. Further developments target combination therapy in MCL and other lymphoid neoplasms.
A Look at VoIP Vulnerabilities (2010)

Voice over IP (VoIP) and Internet Multimedia Subsystem (IMS) technologies offer higher flexibility than traditional telephony infrastructures and the potential for lower cost through equipment consolidation and new business models. In this article, I examine the current state of affairs on VoIP/IMS security through a survey of all the 221 known/disclosed security vulnerabilities in the Common Vulnerabilities and Exposures (CVE) database and in IETF RFCs/drafts. My key finding is that the higher complexity of VoIP/IMS systems leads to a variety of attack vectors, many of them caused by unforeseen and unexpected component interactions. A second finding is that what people seem to worry about in VoIP (traffic interception and impersonation) bears no resemblance to the distribution of vulnerabilities actually disclosed. The article concludes with some practical suggestions for securing VoIP systems.
Application of an Inverse Heat Conduction Solution with Laplace Transform Technique for a Steel Cooling Processes (2021)

When we evaluate complicated cooling heat transfer characteristics of high-temperature steel with water, a solution of the inverse heat conduction problem (IHCP) is essential to specify the surface heat flux and surface temperature change with time from the measurement of the inside solid temperatures. In the present study, the analytical solution of the IHCP with the Laplace transform technique proposed by Monde is applied to steel cooling processes. This technique deals uniform and constant thermal properties of the solid, and the measured temperature change at two depths is approximated with half-power polynomials of time. The steel cooling processes show a very high cooling rate and a large temperature drop after quenching. Therefore, the temperature dependence of thermophysical properties could not be negligible, and much better accuracy of the approximate functions is also required for the complicated measured temperature history. We applied modifications to the analysis, such as a simple and explicit treatment of the temperature-depending properties and superimposing approximate functions. The accuracy of the modified technique was assessed for quenching temperature histories in a steel specimen. From the sensibility of approximation parameters constructing the superimposed functions, the optimum parameters were specified for the measured temperature of quenching experiments. The explicit treatment of the thermal properties ensures accurate estimation results for a higher cooling rate, in which the product of the temperature gradient near the surface and the temperature gradient of the thermal conductivity is small.
S3151 Personalised Combination Antibiotic Therapy Is Effective for Constipation (2020)

INTRODUCTION: Constipation-predominant irritable bowel syndrome (IBS-C) is characterised by symptoms of infrequent and/or difficult to pass stools. IBS-C can also be associated with abdominal pain, bloating, flatulence and fatigue. Due to lack of effective treatments, it is important to investigate promising alternative therapies in order to normalise bowel frequency, and reduce other symptoms. We had previously noticed that using combined antibiotics for H pylori often eased IBS-C, and that vancomycin can improve defecation1, 2. This study aimed to investigate the efficacy of personalised combination antibiotic treatments for IBS-C and evaluate the patients’ clinical outcomes. METHODS: This retrospective, single centred study included patients 16 years or older, diagnosed with IBS-C (and no other underlying disease) who attended our Clinic for treatment between June 2017 and June 2018. Patients treated with combination rifaximin and vancomycin with or without any other medications were included in the study. Demographics and symptoms including bowel frequency data at baseline and 8-weeks on-treatment were recorded. Wilcoxon signed rank test was used to compare the differences pre and on-treatment. P values of < 0.05 were considered significant. RESULTS: A total of 57 patients (M 16, median age 43) diagnosed with IBS-C were included in the study. In addition to infrequent bowel motions, the most common symptoms experienced by this cohort were bloating (65%) and abdominal pain (49%). Patients undertook 7 personalised treatment combinations which all included rifaximin and vancomycin with or without other medications (Table 1). Out of the 57 patients treated for IBS-C, 46 (81%) had a follow-up available at 8 weeks on-treatment. A significant improvement in the frequency of bowel motions (BM) was observed at 8 weeks on-treatment (median BM = 1/day) compared to the baseline (median BM = 1/3-4days) (P < 0.001). The only side effect reported was mild diarrhoea which was experienced with 3 patients during the antibiotic course. CONCLUSION: This study demonstrates the efficacy of personalised treatment comprising of combination of antibiotics such as rifaximin and vancomycin in the treatment of IBS-C. Importantly, a significant increase in number of bowel motions was observed among patients. Future studies need to investigate the efficacy of these antibiotics in relieving the symptoms of constipation and their effect on the gut microbiome.Table 1.: Treatment combination types
Reconfigurable Intelligent Surface-Assisted Cell-Free Massive MIMO Systems Over Spatially-Correlated Channels (2021)

Cell-Free Massive multiple-input multiple-output (MIMO) and reconfigurable intelligent surface (RIS) are two promising technologies for application to beyond-5G networks. This paper considers Cell-Free Massive MIMO systems with the assistance of an RIS for enhancing the system performance under the presence of spatial correlation among the engineered scattering elements of the RIS. Distributed maximum-ratio processing is considered at the access points (APs). We introduce an <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">aggregated channel</i> estimation approach that provides sufficient information for data processing with the main benefit of reducing the overhead required for channel estimation. The considered system is studied by using asymptotic analysis which lets the number of APs and/or the number of RIS elements grow large. A lower bound for the channel capacity is obtained for a finite number of APs and engineered scattering elements of the RIS, and closed-form expressions for the uplink and downlink ergodic net throughput are formulated in terms of only the channel statistics. Based on the obtained analytical frameworks, we unveil the impact of channel correlation, the number of RIS elements, and the pilot contamination on the net throughput of each user. In addition, a simple control scheme for optimizing the configuration of the engineered scattering elements of the RIS is proposed, which is shown to increase the channel estimation quality, and, hence, the system performance. Numerical results demonstrate the effectiveness of the proposed system design and performance analysis. In particular, the performance benefits of using RISs in Cell-Free Massive MIMO systems are confirmed, especially if the direct links between the APs and the users are of insufficient quality with high probability.
Quantitative PCR – new diagnostic tool for quantifying specific mRNA and DNA molecules: HER2/neuDNA quantification with LightCycler real‐time PCR in comparison with immunohistochemistry and fluorescencein situhybridization (2004)

Previously, polymerase chain reaction (PCR) technology has been hampered by its inability to generate quantitative results, a drawback inherent to the high degree of amplification taking place in the reaction. Recently, PCR techniques have been described with the potential of quantifying the amount of mRNA or DNA in biological samples. In this study quantitative PCR was used to investigate the role of the EGF (epidermal growth factor) system in cancer both for measurements of mRNA concentrations and for measurements of the number of copies of specific genes. It is shown that the mRNA expression of a subset of ligands from the EGF system is increased in bladder cancer. Furthermore, measurement of the mRNA concentration gives important information such as the expression of these ligands correlated to the survival of the patients. In addition to the alterations at the mRNA level, changes also can occur at the DNA level in the EGF system. Thus, it has been demonstrated that the number of genes coding for the human epidermal growth factor receptor 2 (HER2) is increased in a number of breast tumors. It is now possible to treat breast cancer patients with a humanized antibody reacting with HER2, and the treatment is considered to be justified if the tumor displays an increased amount of HER2. For this reason there is a need for techniques suitable for HER2 measurements. A LightCycler real-time PCR method used for HER2/neu DNA quantification was evaluated and the results compared with those obtained by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Tumor biopsies were collected from 112 patients diagnosed with early breast cancer from January 1990 to March 1994. The samples were analyzed for HER2 DNA amplification by real-time PCR on LightCycler and by FISH and for HER2 protein expression by IHC. Inter-assay variation for HER2 measured by LightCycler was 10% (x =3.1; n=17). Amplification > or = 2 was observed in 19% of the patients. Concordance rates between real-time PCR and the other methods were 91% (IHC) and 92% (FISH). The correlation between real-time PCR and FISH was highly significant (p < 0.001). The "LightCycler-HER2/neu DNA quantification kit" produces results with a high level of reproducibility and its ease of use allows rapid screening for amplification of HER2. In this paper useful information is given on how real-time PCR compares with FISH and IHC. The data show that results obtained for amplification of HER2 by real-time PCR on the LightCycler instrument are comparable to results obtained by IHC and FISH.
Comparative Mechanical Properties of Spinal Cable and Wire Fixation Systems (1997)

Titanium, steel, and polyethylene cable systems all behave substantially differently mechanically compared with monofilament wire. The relative advantages and disadvantages of each particular products should be considered when selecting an implant for a specific clinical use.
Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission (2020)

Abstract The oxytocin receptor (OXTR) is concentrated in specific brain regions, exemplified by hippocampal subregion CA2, that support social information processing. Oxytocinergic modulation of CA2 directly affects social behavior, yet how oxytocin regulates activity in CA2 remains incompletely understood. We found that OXTR stimulation acts via closure of M-current potassium channels in all OXT-sensitive CA2 neurons. M-current inhibition was persistent in CA2 pyramidal cells, whose prolonged burst firing required functional coupling of the OXTR to both Gαq and Gαi proteins. Other neuromodulators acted via distinct patterns of G-protein signaling to induce CA2 pyramidal neuron burst firing, underscoring its likely importance. CA2 burst firing impacted hippocampal subregion CA1 where stratum oriens -resident CA1 interneurons were targeted more strongly than CA1 pyramidal cells. Oxytocinergic modulation of interneurons, via CA2 pyramidal cell input and directly, triggered a long-lasting enhancement of CA3-CA1 transmission. Thus, transient activation of oxytocinergic inputs may initiate long-lasting recording of social information.
A bionanocomposite-modified glassy carbon electrode for the determination of 4,4′-methylene diphenyl diamine (2018)

The analytical performance of a modified GCE for the determination of MDA increased with the degree of complexity of the bionanocomposite modification.
The Barajas airport project: how a 400 kV cable system can be safely and fully exploited (2005)

This paper deals with monitoring systems apt to qualify installation and to safely and optimally exploit one of the most advanced cable system in the world for length, voltage and power transmission. To satisfy increasing air traffic in Spain, a third runway has been realized in Barajas Airport in Madrid, Spain. Two existing overhead power lines are not compatible with the airport expansion, and have been therefore undergrounded. In 2002 Pirelli Cables y Sistemas has been awarded a contract by REE (Red Electrica de Espana) for manufacturing and installation of one of the two parallel circuits, and for after-installation test and monitoring system of both circuits, for a total contract value for Pirelli of about 17 Million /spl euro/. Cables are festooned in a narrow tunnel in flat/vertical configuration along tunnels' walls and have been successfully submitted to after-installation AC voltage test and partial discharge (PD) monitoring. AC after-installation voltage test have been performed in agreement with IEC62067 international standards. Specific experience and comparison of PD monitoring from joints with embedded capacitive taps and from link-boxes will be described. Cables temperature is monitored via three single-mode fibre optic distributed sensors (OptoPower/RTTR), providing feedback to forced air-cooling units located along the tunnel. The OptoPower/RTTR (Real Time Thermal Rating) has been requested by REE to control cables temperature and therefore regulate forced air-cooling unit intervention. System architecture and logic will be described in detail. RTTR, after installation, has been tested in order to verify data transmission network, PLC, sensors, functional logic and algorithm of control and the main PC control unit. These experiences will be described.
Supplementary Data from Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado (2023)

Supplementary Data from Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado
TAGME (2010)

We designed and implemented TAGME, a system that is able to efficiently and judiciously augment a plain-text with pertinent hyperlinks to Wikipedia pages. The specialty of TAGME with respect to known systems [5,8] is that it may annotate texts which are short and poorly composed, such as snippets of search-engine results, tweets, news, etc.. This annotation is extremely informative, so any task that is currently addressed using the bag-of-words paradigm could benefit from using this annotation to draw upon (the millions of) Wikipedia pages and their inter-relations.
Local Inversion For Anistropy From Qp-Wave Slowness And Polarization Vectors (2001)

Abstract Data from multi-azimuthal walkaway VSPs are very useful for detection and determination of local anisotropy at individual receivers in a borehole.
The vasopressin and copeptin response to infection, severe sepsis, and septic shock* (2009)

Severe sepsis induced a stronger AVP response than infection without systemic inflammation. However, the lack of a difference in AVP plasma concentrations between patients with and without shock indicates that the AVP system does not function normally in severe sepsis. Our data support the hypothesis that impaired AVP response is at least partially responsible for the failure to restore vascular tone in septic shock.
Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg (2020)

There is significant interest in the use of cannabinoids for the treatment of many epilepsies including absence epilepsy (AE). Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model many aspects of AE including the presence of spike-and-wave discharges (SWDs) on electroencephalogram (EEG) and behavioral comorbidities, such as elevated anxiety. However, the effects of cannabis plant-based phytocannabinoids have not been tested in GAERS. Therefore, we investigated how SWDs in GAERS are altered by the two most common phytocannabinoids, Δ<sup>9</sup> -tetrahydrocannabinol (THC) and cannabidiol (CBD), and exposure to smoke from two different chemovars of cannabis. Animals were implanted with bipolar electrodes in the somatosensory cortex and EEGs were recorded for 2 hr. Injected THC (1-10 mg/kg, i.p.) dose-dependently increased SWDs to over 200% of baseline. In contrast, CBD (30-100 mg/kg, i.p.) produced a ~50% reduction in SWDs. Exposure to smoke from a commercially available chemovar of high-THC cannabis (Mohawk, Aphria Inc.) increased SWDs whereas a low-THC/high-CBD chemovar of cannabis (Treasure Island, Aphria Inc.) did not significantly affect SWDs in GAERS. Pre-treatment with a CB1R antagonist (SR141716A) did not prevent the high-THC cannabis smoke from increasing SWDs, suggesting that the THC-mediated increase may not be CB1R-dependent. Plasma concentrations of THC and CBD were similar to previously reported values following injection and smoke exposure. Compared to injected CBD, it appears Treasure Island did not increase plasma levels sufficiently to observe an anti-epileptic effect. Together these experiments provide initial evidence that acute phytocannabinoid administration exerts the biphasic modulation of SWDs and may differentially impact patients with AE.
Hand and fibrillin‐1 deposition abnormalities in Loeys–Dietz syndrome—expanding the clinical spectrum (2013)

Loeys-Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized by hypertelorism, bifid uvula, cleft palate and arterial tortuosity. We report on a patient with LDS, bearing mutation in the TGFβR2 gene, whose prenatal examination demonstrated clenched fists and club feet, suggesting arthrogryposis multiplex congenita. Postnatal assessment showed digital abnormalities, including brachydactyly, camptodactyly, partial syndactyly and absent distal phalanges. With the lack of fibrillin-1 microfibril deposition as well as impaired and inadequate elastic fiber assembly in our patient's fibroblasts, we speculate that the skeletal abnormalities seen in this patient with LDS are the result of lack of these components in embryonal perichondrium and in blood vessels. We suggest that LDS should be included in the differential diagnosis of joint contractures seen pre and postnatally. Prenatal diagnosis of LDS would be important in parental counseling and early post natal diagnosis could prompt treatment before the development of detrimental vascular complications.
ChemInform Abstract: Graphene‐Based Composites (2012)

Abstract Review: 279 refs.
ECG based detection of body position changes (2003)

Changes in body position are sometimes mistaken for as myocardial ischemia during ambulatory ECG monitoring. Two different methods for detecting body position changes based on spatial and scalar approaches are investigated. The results show that reliable detection is possible in more than 90% of the cases.
Extended x-ray absorption fine-structure studies of the internal aggregate structure in lightly sulfonated polystyrene. 1. Determination of the coordination environment about the cation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtended x-ray absorption fine-structure studies of the internal aggregate structure in lightly sulfonated polystyrene. 1. Determination of the coordination environment about the cationB. P. Grady and S. L. CooperCite this: Macromolecules 1994, 27, 22, 6627–6634Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ma00100a056https://doi.org/10.1021/ma00100a056research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The orthogonal shim coil at 3-Tesla (2018)

We purpose an integrated RF-shim coil array, where the shimming current path and the RF receiving coil are arranged on two orthogonal planes to minimize the mutual coupling. This design was implemented as an array consisting of seven shim coils and a 32-channel RF-shim array. The 39-channel RF-shim coil array has marginal SNR loss and improved the global shimming by 9, compared to the 32-channel RF-shim array.