gebhart/patrepeval huggingface dataset:
Self-Assembled, Nanostructured Polypyrrole Films Grown in a High-Gravity Environment (2012)

A simple, novel method of synthesizing self-assembled, nanostructured conducting polymer films has been developed. Applying an increased centrifugal force on the electrodes during the electrochemical deposition process yields high surface area, micro- or nanostructured polymer films. Scanning electron microscopy showed that as the applied g-force increased, the polymers progressed from having smooth, "cauliflower" morphologies, to intermediate microstructured surfaces, to finally dense nanostructured surfaces with pore sizes as small as 50 nm. Cyclic voltammetry revealed that films grown at higher centrifugal accelerations (higher than 500g) exhibited less degradation after electrochemical cycling and more capacitive behavior.
Post-silicon is too late avoiding the $50 million paperweight starts with validated designs (2010)

To ensure that an intellectual property (IP) block is validated ahead of its use in an 'unknown ' system-on-chip (SoC) context, an holistic view of the integration process must be taken. We will focus on the challenges faced in integrating and manufacturing advanced low-power processor based SoC systems, which have dramatically increased the complexity & state space for logical and electrical validation. We describe the process taken by IP providers, tool vendors and the foundry supply chain to enable first time logical, electrical and manufacturing closure. We discuss how feedback is used to improve component IP validation strategies and interoperability and integration testing. We also cover techniques such as the role of hardware/software emulation for configuration testing, the application of formal techniques and advanced electrical rules checking. In addition, we will examine the role waivers and automated design-in guidelines to enable the integrator to balance risk reduction and design turnaround time. Finally we discuss manufacturing tests and how to link these back to improve the metrics used for component and integration level testing.
Relaxational contributions to protein compressibility from ultrasonic data (1979)

Abstract The ultrasonic absorption spectra of proteins in solution generally show relaxational behaviour. There will be a corresponding dispersion of sound velocities accompanying each relaxation. The compressibility of the protein as measured by sound velocity techniques will therefore include a relaxational contribution. We have evaluated this contribution for a number of proteins and found that in some cases the relaxational contribution is a significant fraction of the total compressibility. The relaxational contribution will be large only if the molecule has a large number of degrees of freedom with low force constants. However, such motions are likely to be those involved in the biological functioning of the molecule. Care is needed in interpreting the relaxation spectrum since proton transfer processes give large apparent relaxational compressibilities.
Venus: Scalable Real-Time Spatial Queries on Microblogs with Adaptive Load Shedding (2015)

Microblogging services have become among the most popular services on the web in the last few years. This led to significant increase in data size, speed, and applications. This paper presents <i>Venus</i> ; a system that supports real-time spatial queries on microblogs. <i>Venus</i> supports its queries on a spatial boundary <inline-formula><tex-math notation="LaTeX">$R$</tex-math></inline-formula> and a temporal boundary <inline-formula><tex-math notation="LaTeX">$T$</tex-math></inline-formula> , from which only the top- <inline-formula><tex-math notation="LaTeX">$k$</tex-math></inline-formula> microblogs are returned in the query answer based on a spatio-temporal ranking function. Supporting such queries requires <i>Venus</i> to digest hundreds of millions of real-time microblogs in main-memory with high rates, yet, it provides low query responses and efficient memory utilization. To this end, <i>Venus</i> employs: (1) an efficient in-memory spatio-temporal index that digests high rates of incoming microblogs in real time, (2) a scalable query processor that prune the search space, <inline-formula><tex-math notation="LaTeX">$R$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$T$</tex-math></inline-formula> , effectively to provide low query latency on millions of items in real time, and (3) a group of memory optimization techniques that provide system administrators with different options to save significant memory resources while keeping the query accuracy almost perfect. <i>Venus</i> memory optimization techniques make use of the local arrival rates of microblogs to smartly shed microblogs that are old enough not to contribute to any query answer. In addition, <i>Venus</i> can adaptively, in real time, adjust its load shedding based on both the spatial distribution and the parameters of incoming query loads. All <i>Venus</i> components can accommodate different spatial and temporal ranking functions that are able to capture the importance of each dimension differently depending on the applications requirements. Extensive experimental results based on real Twitter data and actual locations of Bing search queries show that <i>Venus</i> supports high arrival rates of up to 64 K microblogs/second and average query latency of 4 msec.
High‐frequency vaccine‐induced CD8+ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection (2014)

Relatively few MHC class I epitopes have been identified from Mycobacterium tuberculosis, but during the late stage of infection, CD8(+) T-cell responses to these epitopes are often primed at an extraordinary high frequency. Although clearly available for recognition during infection, their role in resistance to mycobacterial infections still remain unclear. As an alternative to DNA and viral vaccination platforms, we have exploited a novel CD8(+) T-cell-inducing adjuvant, cationic adjuvant formulation 05 (dimethyldioctadecylammonium/trehalose dibehenate/poly (inositic:cytidylic) acid), to prime high-frequency CD8 responses to the immunodominant H2-K(b) -restricted IMYNYPAM epitope contained in the vaccine Ag tuberculosis (TB)10.4/Rv0288/ESX-H (where ESX is mycobacterial type VII secretion system). We report that the amino acid C-terminal to this minimal epitope plays a decisive role in proteasomal cleavage and epitope priming. The primary structure of TB10.4 is suboptimal for proteasomal processing of the epitope and amino acid substitutions in the flanking region markedly increased epitope-specific CD8(+) T-cell responses. One of the optimized sequences was contained in the closely related TB10.3/Rv3019c/ESX-R Ag and when recombinantly expressed and administered in the cationic adjuvant formulation 05 adjuvant, this Ag promoted very high CD8(+) T-cell responses. This abundant T-cell response was functionally active but provided no protection against challenge, suggesting that CD8(+) T cells play a limited role in protection against M. tuberculosis in the mouse model.
Retrospective: the J-machine (1998)

Article Free Access Share on Retrospective: the J-machine Authors: William J. Dally Computer Systems Laboratory, Stanford University Computer Systems Laboratory, Stanford UniversityView Profile , Andrew Chien Department of Computer Science, University of Illinois, Urbana-Champaign Department of Computer Science, University of Illinois, Urbana-ChampaignView Profile , Stuart Fiske Silicon Graphics Computer, Systems Silicon Graphics Computer, SystemsView Profile , Waldemar Horwat Netscape Communications Netscape CommunicationsView Profile , Richard Lethin Equator Technologies Consulting Equator Technologies ConsultingView Profile , Michael Noakes View Profile , Peter Nuth Hewlett Packard, Laboratories Hewlett Packard, LaboratoriesView Profile , Ellen Spertus Department of Computer Science, Mills College Department of Computer Science, Mills CollegeView Profile , Deborah Wallach DEC, Western Research Laboratory DEC, Western Research LaboratoryView Profile , D. Scott Wills Department of Electrical, and Computer Engineering, Georgia Institute of Technology Department of Electrical, and Computer Engineering, Georgia Institute of TechnologyView Profile , Andrew Chang Computer Systems Laboratory, Stanford University Computer Systems Laboratory, Stanford UniversityView Profile , John Keen Silicon Graphics Computer, Systems Silicon Graphics Computer, SystemsView Profile Authors Info & Claims ISCA '98: 25 years of the international symposia on Computer architecture (selected papers)August 1998 Pages 54–58https://doi.org/10.1145/285930.285953Online:01 August 1998Publication History 8citation476DownloadsMetricsTotal Citations8Total Downloads476Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Optimizing services selection in a cloud multiplatform scenario (2012)

Services selection is an important challenge for applications that use a composition of services provided by different cloud platforms. This paper presents an optimized cloud services selection approach that evaluates each alternative set of services that composed an execution plan. This approach considers cost and quality parameters for each cloud service in the execution plan, and excludes coincident services in the calculations. Coincident services are those services present in all available execution plans and therefore equally contribute in the calculations encompassing costs and quality parameters regarding these plans. By excluding coincident services, the service selection process by itself should be performed more quickly since it involves a smaller number of services, but with the trade-off of running an additional algorithm for identifying the coincident services among the available ones. In order to evaluate such trade-off and illustrate the proposed approach, we present a case study and an experimental evaluation that compares our new approach with a previous one that considers all services that compose all available execution plans.
Granulocyte‐colony stimulating factor (G‐CSF) producing malignant pleural mesothelioma: Report of a case (2014)

This report presents a case of malignant pleural mesothelioma (MPM) producing granulocyte colony-stimulating factor (G-CSF) that was treated by tumor resection. A 76-year-old male presented with a huge right-side chest wall tumor, along with a slight fever and chest wall pain. Laboratory findings showed an increased white blood cell count (64600 cells/μL) and C-reactive protein level (20.57 mg/dL). The patient underwent surgical removal of the tumor along with tissue from the chest wall and histopathological analysis led to a diagnosis of sarcomatous type of MPM. Immunohistochemical findings for both anti-human G-CSF and interleukin-6 monoclonal antibodies were positive. Although the general condition of the patient quickly improved after surgery, local recurrence occurred two months later and he died of respiratory failure seven months after the operation, though surgery provided symptom relief. G-CSF-producing MPMs usually show a poor prognosis, though less-invasive surgery may be considered for relief of symptoms.
Software to Stress Test Image Quality Estimators (2016)

An image quality estimator (QE) can be used to improve the performance of a system, but only if its scores are easily interpretable. In this paper, we present software, entitled “Stress Testing Image Quality Estimators (STIQE)” that systematically explores the performance of a QE, with the goal of enabling users to interpret the QE's scores. Our software allows consistent and reproducible benchmarks of new QEs as they are developed, so the most effective QE for an application can be chosen. We demonstrate that results produced by the software provide new insights into hidden aspects of existing QEs.
Localization in Wireless Terahertz Communications: An Imaging Problem and A Spectral Encoding Solution (2022)

Terahertz communications is a likely candidate for future generations of wireless technology. At THz frequencies, communications and imaging are intrinsically related as sensing the environment is required prior to establishing a communication link. Here, we propose spectral encoding techniques.
On the optically transparent WDM ATM multicast (3M) switches (1996)

Abstract We describe an architecture design and implementation of the optically transparent wavelength-division-multiplexed (WDM) asynchronous-transfer-mode (ATM) multicast (3M) switch for all optical high-speed networks. By using the WDM techniques, the wire complexity in both the switch fabric and the concentrator can be reduced from O(N2) to O(N). By using integrated photonic devices and highly parallel processing and pipeline control electronic circuits the switch is handling signals at the cell level (53 bytes) instead of at the bit level and can achieve very high speed and high throughput operation. Several key components, including a cell synchronizer, a photonic VCI over-writting unit, a wavelength converter, an optical concentrator, and a WDM memory, have also been proposed to realize this 3M switch. All of the photonic devices are highly integratable and are very suitable for building future large-scale, low-cost photonic ATM switches. A combination of both the ATM and WDM techniques will provide an ultimate version for optical networking with almost unlimited capacity.
Prolonged 500 °C Operation of 6H-SiC JFET Integrated Circuitry (2009)

This paper updates the long-term 500 °C electrical testing results from 6H-SiC junction field effect transistors (JFETs) and small integrated circuits that were introduced at ICSCRM-2007. Two packaged JFETs have now been operated in excess of 7000 hours at 500 °C with less than 10% degradation in linear I-V characteristics. Several simple digital and analog demonstration integrated circuits successfully operated for 2000-6500 hours at 500 °C before failure.
Parallel image thinning through topological operators on shared memory parallel machines (2009)

In this paper, we present a concurrent implementation of a powerful topological thinning operator. This operator is able to act directly over grayscale images without modifying their topology. We introduce an adapted parallelization methodology which combines split, distribute and merge (SDM) strategy and mixed parallelism techniques (data and thread parallelism). The introduced strategy allows efficient parallelization of a large class of topological operators including, mainly, ¿-leveling, skeletonization and crest restoring algorithms. To achieve a good speedup, we cared about coordination of threads. Distributed work during thinning process is done by a variable number of threads. Tests on 2D grayscale image (512*512), using shared memory parallel machine (SMPM) with 8 CPU cores (2× Xeon E5405 running at frequency of 2 GHz), showed an enhancement of 6.2 with a maximum achieved cadency of 125 images/s using 8 threads.
BASS: Bayesian Analyzer of Event Sequences (1996)

We describe the BASS system, a Bayesian analyzer of event sequences. BASS uses Markov chain Monte Carlo methods, especially Metropolis-Hastings algorithm, for exploring posterior distributions. The system allows the user to specify an intensity model in a high-level definition language, and then runs the Metropolis-Hastings algorithm on it.
Longitudinally resolved measurement of plasma density along femtosecond laser filament via terahertz spectroscopy (2014)

We report on a longitudinally resolved measurement of plasma density along femtosecond laser filament in air via terahertz (THz) spectroscopy. By applying a needlelike high-voltage direct current (DC) electric field on the laser filament and scanning it along filament, the longitudinal evolution of amplified THz emission has been demonstrated. The peak frequency of the DC electric field biased THz emission is proportional to the plasma density inside the laser filament. This latter phenomenon was used to characterize the plasma density. Longitudinal distribution of plasma density of ∼1015 cm−3 along laser filament has been experimentally recorded. The technique demonstrated is very simple and helpful for understanding the THz generation process through laser filamentation.
Characterization of a benzyladenine binding-site peptide isolated from a wheat cytokinin-binding protein: sequence analysis and identification of a single affinity-labeled histidine residue by mass spectrometry. (1988)

A wheat embryo cytokinin-binding protein was covalently modified with the radiolabeled photoaffinity ligand 2-azido-N6-[14C]benzyladenine. A single labeled peptide was obtained after proteolytic digestion and isolation by reversed-phase and anion-exchange HPLC. Sequencing by classical Edman degradation identified 11 of the 12 residues but failed to identify the labeled amino acid. Analysis by laser photodissociation Fourier-transform mass spectrometry of 10 pmol of the peptide independently confirmed the Edman data and also demonstrated that the histidine residue nearest the C terminus (underlined) was modified by the reagent in the sequence Ala-Phe-Leu-Gln-Pro-Ser-His-His-Asp-Ala-Asp-Glu.
Surgical coronary revascularization remains relevant in the era of stents (2004)

Although CBIs for CAD are now performed more often than surgical procedures, surgery remains an important treatment option.
Novel monocyte-like properties of microglial/astroglial cells. Constitutive secretion of lysozyme and cystatin-C. (1987)

Evidence implicates cells belonging to the mononuclear phagocytic system (MPS) in the development of some forms of amyloidosis (10, 22). Whether or not the MPS is involved in central nervous system amyloidosis is not known. As a first step to address this issue, microglial and astroglial cells isolated from mouse brains were cultured and characterized as to the properties they may share with other members of the MPS. It was shown by light and electron microscopy that both cell types phagocytose latex particles, but that only microglial cells engulf immunoglobulin sensitized erythrocytes. By means of immunohistochemical, immunofluorescence, and immunoblotting techniques, it was established that the cells contain and secrete lysozyme as well as the proteinase inhibitor cystatin-C (-gamma trace). Cystatin-C was distributed in the cytoplasm and the nucleus and was strikingly associated with filaments and bundles of fibrils. Another enzyme, commonly used to distinguish cells belonging to the MPS, is alpha-naphthyl butyrate esterase. Shortly after their isolation, only the microglial cells were positive, but on continued culturing, increasing numbers of astroglial cells became positive for alpha-naphthyl butyrate esterase. By day 22, almost all of the cells were positive. Freshly isolated cells were negative for the monocyte-specific antigen Mac-1. However, after 4 days, cells with the morphology of microglia had become positive, whereas astroglia failed to exhibit this antigen with up to 22 days in culture. Thus, both astroglia and microglia have properties in common with cells of the MPS which may be useful for future studies. However, on fresh isolation only microglia were indistinguishable from monocytes for all features tested.
P6546Canadian Registry of Electronic Device Outcomes (CREDO): remote monitoring outcomes in the abbott battery performance alert, a multicentre cohort (2019)

Abstract Background Cardiac implantable electronic devices have been known to have lead and device malfunctions leading to advisories. Increased use of remote monitoring of devices has been suggested to allow the identification of abnormal device performance and allow early intervention. We sought to describe the outcomes of patients with and without remote monitoring of in devices in the Abbott Premature Battery Depletion advisory with data from a Canadian registry Methods Patients with an Abbott device subject to the Battery Performance Alert Advisory from nine ICD implanting centres in Canada were included in the registry. The use of remote monitoring was identified from baseline and followup data in the registry. The primary outcome was detection of premature battery depletion and all cause mortality. Results 2679 patents were identified with a device subject to the advisory. Devices were implanted between 2010 and 2017. 1716 patients (64%) had remote monitoring at baseline with this increasing to 83.7% at followup at 12 months. Premature battery depletion occurred in 43 patients (1.6%). Discovery of premature battery depletion was detected by remote monitoring in 70% of patients. There were 492 deaths during the follow up. Mortality was higher in those without a remote monitor compared to those with a remote monitor at follow-up and remote monitor at baseline and follow-up (11.3%, 2.6% versus 6.1% respectively; p=0.0186). There were no deaths attributed to premature battery depletion Conclusion The use of remote monitoring in patients with ICD and CRT under advisory reliably detected device failure and was associated with a reduction in all-cause mortality.
Reappraisal of Empirical Solvent Polarity Scales for Organic Solvents (2020)

Abstract Correlations of Reichardt's E T (30), the Catalán SdP (solvent dipolarity), SP (solvent polarizability), SA (solvent acidity), SB (solvent basicity), Kamlet‐Taft π * (dipolarity/polarizability), α (hydrogen bond donating ability) and β (hydrogen bond accepting ability) polarity parameters with the molar concentration of 161 pure organic solvents are presented. Mostly, linear relationships of the polarity parameter as a function of molar concentration are obtained as long as each individual solvent class is considered separately. A physically different interpretation of the E T (30), Kamlet‐Taft π * and α as well as Catalán SA and SB parameters has been proposed. Furthermore, the Hildebrand solubility parameter in combination with the diffraction index is used for the correlation analysis with the above‐mentioned solvent parameters. It can be concluded that empirical polarity parameters derived from solvatochromic UV/Vis measurements are inherently a function of the molecular structure of the probe.
Flow Characteristic Induced by a V-shape Mixer in a Stirred-Tank Reactor (2003)

A mixing system is used as a unit operation in every field of chemical plant, and is used not only for mixing but also heating, cooling, melting, reaction and so on. In such a mixing system, when the rotation speed of a rotor increased beyond a certain critical value, the centrifugal force makes the flow between the rotor and the outer cylinder unstable. The instability leads to the transition to a cellular vortex flow, i.e. Taylor vortex flow. The Taylor vortex flow has a great influence on the efficiency of mixing. This paper describes fundamental flow characteristics in such a mixing system based on the quantitative flow visualization.
Laser drilling micro-holes on a novel coronary drug delivery catheter (1997)

A unique catheter developed for delivering drugs locally into the coronary arteries requires an array of high precision holes ‘drilled’ into the distal end of a polymeric extrusion. Determination of the correct technology, i.e. wavelength, pulse energy, beam geometry, and fixturing were all crucial elements in developing a process that was not only accurate and repeatable, but also manufacturable. The process was also had to meet the requirements of the medical device regulatory environment (GMP’s, ISO’s). This combination of requirements can be a ‘tall order’ in the laser job shop industry, particularly when making the leap from an R&amp;D effort into full production.