gebhart/patrepeval huggingface dataset:
The Gene Encoding the Mitogen-responsive Phosphoprotein Dab2 Is Differentially Regulated by GATA-6 and GATA-4 in the Visceral Endoderm (2000)

Gene targeting studies have demonstrated that the zinc finger transcription factor GATA-6 lies upstream in a transcriptional cascade that controls differentiation of the visceral endoderm. To understand the function of GATA-6 in the visceral endoderm and to identify genes regulated by GATA-6 in this tissue, subtractive hybridization was performed using template cDNAs derived from differentiated wild-type embryonic stem (ES) cells and GATA-6(-/-) ES cells, respectively. These analyses revealed that the gene encoding Dab2, a mitogen-responsive phosphoprotein, is differentially expressed in wild-type and GATA-6-deficient ES cells. Consistent with these findings, Dab2 is expressed in the visceral endoderm of wild-type embryos but not in the visceral endoderm of GATA-6-deficient embryos. Cotransfection experiments demonstrate that the human Dab2 promoter can be transactivated by forced expression of GATA-6 in NIH-3T3 cells. In contrast, forced expression of GATA-4 does not transactivate the human Dab2 promoter and Dab2 is expressed in the visceral endoderm of GATA-4 null embryos. Surprisingly, the specificity of GATA-6-induced transactivation of the Dab2 promoter is not mediated through its zinc finger DNA-binding domain. Taken together, these data demonstrate that the mitogen-responsive phosphoprotein Dab2 is a downstream target of GATA-6 in the visceral endoderm. Moreover, these data demonstrate that molecular mechanisms have evolved that direct, and distinguish, the functional specificity of GATA family members when they are developmentally coexpressed.
Robot-Assisted Laparoscopic Myomectomy Compared With Standard Laparoscopic Myomectomy (2012)

II.
Four-fiber Fan-out for MCF with Square Lattice Structure (2017)

Fiber bundle Fan-out for MCF with square lattice structure is investigated. Core position error from ideal position is simulated using Brownian movement theory. Insertion loss with MCF &lt; 0.4 dB is achieved.
Correlated noise cancellation in fractional sampling orthogonal frequency and code division multiplexing with alternative spreading code (2010)

Orthogonal frequency and code division multiplexing (OFCDM) has received large attention as a modulation scheme to realise high data rate transmission. The OFCDM system with fractional sampling (FS) is investigated. FS is a diversity scheme with a single antenna, which achieves path diversity through oversampling and parallel signal reception. However, the correlation among noise components may deteriorate the bit error rate performance at the receiver as the number of subcarriers and oversampling ratio increases. To overcome this problem, the alternative spreading code is used for the FS OFCDM system. Numerical results through computer simulation show that the proposed scheme can improve the performance of the receiver with the large oversampling ratio and the number of subcarriers.
Motion and Depth Deblurring Using Integrated PSF (2014)

近年，カメラのぼけ関数(PSF)を用いてデコンボリューションを行うことで，奥行ぼけや動きぼけの復元を行う研究が進みつつある．特に，コンピュテーショナルフォトグラフィの研究の進展により，被写体の奥行が一定でない3次元シーンにおいても全焦点画像の生成や被写界深度の制御が可能になりつつある．本稿では，カメラを露光中に移動させることにより，画像中での物体の動きの方向や大きさによらずPSFがほぼ不変となることを示し，この性質を用いることで物体の動きの方向や大きさに依らず動きぼけの復元が可能であることを示す．この撮像方法では，任意の奥行きを持つ物体の奥行きぼけ復元が可能であることがすでに知られている．一方，提案法では任意の奥行きに存在する任意の動きを持つ物体の奥行きぼけと動きぼけを同時に復元することが可能である．実画像実験を行うとともに，レンズシミュレータを用いてぼけ復元精度を定量的に評価することで，提案法の有用性を示す．
Enhancing the performance of coupled cavity-antenna plasmonic nanostructures for ultrafast quantum photonics (2020)

We analytically establish the fundamental limit for quantum emission enhancement in plasmonic nanostructures combining smaller (cavity) and larger (antenna) modes. We confirm this result numerically and optimize the performance of nanoantennas experimentally through controlled photomodification.
Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate (1978)

Two patients recieving intravenous high dose methotrexate (MTX) and intracutaneous BCG injections as adjuvant treatment for osteogenic sarcoma suffered sudden cardiovascular collapse within minutes of infusion of MTX. These cases demonstrate that anaphylactic or idiosyncratic reactions to MTX and/or contaminants in these preparations do occur and that careful patient monitoring is required.
Beyond 100Gb/s (2016)

Advanced coherent modulations, increased symbol rate, and superchannels enable optical connections of 150, 200, 400, or 1000+ Gb/s. Enhanced signal processing in CMOS allows superior reaches to be cost-effectively achieved in commercial networks. Article not available.
The Optimization of Conductive Inks for 3D Inkjet Printing (2014)

Commercially available nanoparticle precursor conductive inks are designed to prevent the blockage of the print-head nozzles by using low evaporation rate binder solvents. This low evaporation rate has the consequence of long drying times for those conductive inks which makes 3D printing of conductive routes a lengthy process.In this paper we identify a number of solvents that have suitable properties to prevent nozzle blockage and allow for enhanced drying rates so that multiple conductive layers can be printed within a short time to form 3D conductive elements. To achieve this propylene glycol monomethyl ether acetate (PGMEA) was used as a solvent to form a 30 wt% silver conductive ink which, after sintering, reached a resistivity of 1.66 &#x3BC;&#x3A9;.m.
Confocal light scattering spectroscopic imaging system for in situ tissue characterization (2009)

We report on the design and construction of a confocal light scattering spectroscopic imaging system aimed ultimately to conduct depth-resolved characterization of biological tissues. The confocal sectioning ability of the system is demonstrated using a two-layer sample consisting of a 200 microm thick cancer cell layer on top of a scattering layer doped with a green absorber. The measurement results demonstrate that distinct light scattering signals can be isolated from each layer with an axial and a lateral resolution of 30 and 27 microm, respectively. Such a system is expected to have significant applications in the areas of tissue engineering and disease diagnostics and monitoring.
CP Properties of Higgs Boson Interactions with Top Quarks in the tt¯H and tH Processes Using H→γγ with the ATLAS Detector (2020)

A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented. Higgs bosons are identified via the diphoton decay channel (H→γγ), and their production in association with a top quark pair (tt[over ¯]H) or single top quark (tH) is studied. The analysis uses 139 fb^{-1} of proton-proton collision data recorded at a center-of-mass energy of sqrt[s]=13 TeV with the ATLAS detector at the Large Hadron Collider. Assuming a CP-even coupling, the tt[over ¯]H process is observed with a significance of 5.2 standard deviations. The measured cross section times H→γγ branching ratio is 1.64_{-0.36}^{+0.38}(stat)_{-0.14}^{+0.17}(sys) fb, and the measured rate for tt[over ¯]H is 1.43_{-0.31}^{+0.33}(stat)_{-0.15}^{+0.21}(sys) times the Standard Model expectation. The tH production process is not observed and an upper limit on its rate of 12 times the Standard Model expectation is set. A CP-mixing angle greater (less) than 43 (-43)° is excluded at 95% confidence level.
Effective Value of Decision Tree with KDD 99 Intrusion Detection Datasets for Intrusion Detection System (2008)

A decision tree is a outstanding method for the data mining. In intrusion detection systems (IDSs), the data mining techniques are useful to detect the attack especially in anomaly detection. For the decision tree, we use the DARPA 98 Lincoln Laboratory Evaluation Data Set (DARPA Set) as the training data set and the testing data set. KDD 99 Intrusion Detection data set is also based on the DARPA Set. These three entities are widely used in IDSs. Hence, we describe the total process to generate the decision tree learned from the DARPA Sets. In this paper, we also evaluate the effective value of the decision tree as the data mining method for the IDSs, and the DARPA Set as the learning data set for the decision trees.
3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures (2018)

The advent of adaptive manufacturing techniques supports the vision of cell-instructive materials that mimic biological tissues. 3D jet writing, a modified electrospinning process reported herein, yields 3D structures with unprecedented precision and resolution offering customizable pore geometries and scalability to over tens of centimeters. These scaffolds support the 3D expansion and differentiation of human mesenchymal stem cells in vitro. Implantation of these constructs leads to the healing of critical bone defects in vivo without exogenous growth factors. When applied as a metastatic target site in mice, circulating cancer cells home in to the osteogenic environment simulated on 3D jet writing scaffolds, despite implantation in an anatomically abnormal site. Through 3D jet writing, the formation of tessellated microtissues is demonstrated, which serve as a versatile 3D cell culture platform in a range of biomedical applications including regenerative medicine, cancer biology, and stem cell biotechnology.
Improved performance of $(20\bar{2}1)$ long-wavelength light-emitting diodes grown with wide quantum wells on stress-relaxed InxGa1−xN buffer layers (2014)

Long-wavelength (>540 nm) single-quantum-well light-emitting diodes were grown pseudomorphically on stress-relaxed InxGa1−xN buffer layers on the orientation. Basal plane dislocation glide led to the formation of misfit dislocations at the bottom of the InxGa1−xN buffer layer. This provided one-dimensional plastic relaxation in the film interior, including the active region. For wider quantum wells (>3.5 nm), the efficiency of devices grown on relaxed buffer layers showed significant improvement compared to reference devices grown with no relaxation, indicating that degradation of thicker active regions can be prevented with partial relaxation via basal plane slip.
Electron-spin-resonance and electrically detected-magnetic-resonance characterization on PbC center in various 4H-SiC(0001)/SiO2 interfaces (2020)

We characterized an intrinsic interface defect, called the “PbC center,” formed at 4H-SiC(0001)/SiO2 interfaces by means of electron-spin-resonance (ESR) and electrically detected-magnetic-resonance (EDMR) spectroscopies. The formation of the PbC center was observed with a spin density of 3–4 × 1012 cm−2 after standard thermal oxidation. This center could be effectively removed by the NO post-oxidation-anneal (POA) process or ultra-high-temperature oxidation and could be passivated by H atoms via the H2 POA process. There was a clear correlation between the PbC center and field-effect mobility (μFE) of 4H-SiC(0001) metal–oxide–semiconductor field effect transistors (MOSFETs). The PbC center decreased μFE because this center acts as electron traps, reducing the free-carrier density in the inversion channel of 4H-SiC(0001) MOSFET. We also examined the counter doping effect of NO POA by introducing 15N impurities; however, the counter doping of 15N donors was not detectable by ESR (much lower than 2 × 1011 cm−2). Highly sensitive EDMR measurements revealed that the PbC center has two isotropic hyperfine (HF) interactions at 1.3 and 6.8 mT and suggested that its main 13C HF interaction should be larger than 14 mT. Based on the present experimental data, the origin of the PbC center was ascribed as a carbon-related interface defect that forms a C–H bond after hydrogen passivation. This feature is similar to that of the porous-PbC centers (carbon dangling-bond centers) found in porous-SiC/SiO2 systems. However, their HF signatures indicated that the PbC center at 4H-SiC(0001)/SiO2 interfaces and the porous-PbC centers in porous-SiC should be different centers associated with different wave functions.
Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis (2011)

Circulating microRNAs in human serum have increasingly been recognized as stable markers for cancer detection. However, there is still a lack of miRNome wide studies over a long period of time with respect to pathogenic processes. We obtained serum samples from the janus serum bank collected prior and after diagnosis of lung cancer. We analyzed the abundance of 904 miRNAs in serum from eight cancer patients at three time points and from six healthy control individuals. Based on the identified miRNA signatures, hierarchical clustering and a self-organizing map identified three major clusters including one cluster containing most of the of the pre-diagnostic samples, a second cluster with mainly post-diagnostic samples, and a third cluster with mainly control samples. Correlation analyses showed that although the profiles were generally stable over several years, most obvious changes of the miRNA pattern seem to occur at a time close to diagnosis. Our findings support the idea that a developing lung cancer might be detectable years prior to diagnosis through a specific miRNA signature and that this signature changes during tumor development.
EUV resist imaging below 50 nm using coherent spatial filtering techniques (2004)

Lithography results using spatially-filtered coherent EUV radiation are presented. These experiments were done using a new 10× Schwarzschild optic and other significant upgrades for high stability and throughput of the system. Included are both single- and multiple-pitch images. A chemically-amplified EUV resist is shown performing at dense 50-nm linewidths and loose 25-nm features. High resolution polymers (HSQ and PMMA) were also tested and demonstrate dense 40-nm linewidths, which are the smallest 1:1 multi-pitch features attempted at this time.
Color naming: color scientists do it between Munsell sheets of color (2009)

With the advent of high dynamic range imaging and wide gamut color spaces, gamut mapping algorithms have to nudge image colors much more drastically to constrain them within a rendering device's gamut. Classical colorimetry is concerned with color matching and the developed color difference metrics are for small distances. For larger distances, categorization becomes a more useful concept. In the gamut mapping case, lexical distance induced by color names is a more useful metric, which translates to the condition that a nudged color may not cross a name boundary. The new problem is to find these color name boundaries. We compare the experimental procedures used for color naming by linguists, ethnologists, and color scientists and propose a methodology that leads to robust repeatable experiments.
On the minimum latency problem (1994)

We are given a set of points $p_1,\ldots , p_n$ and a symmetric distance matrix $(d_{ij})$ giving the distance between $p_i$ and $p_j$. We wish to construct a tour that minimizes $\sum_{i=1}^n \ell(i)$, where $\ell(i)$ is the {\em latency} of $p_i$, defined to be the distance traveled before first visiting $p_i$. This problem is also known in the literature as the {\em deliveryman problem} or the {\em traveling repairman problem}. It arises in a number of applications including disk-head scheduling, and turns out to be surprisingly different from the traveling salesman problem in character. We give exact and approximate solutions to a number of cases, including a constant-factor approximation algorithm whenever the distance matrix satisfies the triangle inequality.
Blood pressure, blood flow and oxygenation in the clipped kidney of long‐term Goldblatt hypertensive rats (2009)

Angiotensin II (Ang II) maintains blood flow (RBF) and oxygenation (pO 2 ) in the clipped kidney of early two‐kidney, one clip Goldblatt hypertensive rats (2K,1C). However, most cases of human renovascular disease are chronic. The involvement of Ang II declines whereas oxidative stress increases during progression of 2K,1C hypertension. We hypothesized that acute administration of drugs to inhibit reactive oxygen species (ROS; tempol), angiotensin converting enzyme (ACE; enalaprilat), Ang II type 1 or 2 receptors (AT 1 or AT 2 ; candesartan or PD‐123,319) lower mean arterial pressure (MAP), RBF and pO 2 in the clipped kidney of chronic 2K,1C. Twelve months after left renal artery clipping, MAP, RBF and pO 2 were measured after acute administration these drugs. MAP of 2K,1C was unchanged by PD123,319, reduced by ACE inhibition and AT1 blockade, and especially by tempol. Only tempol increased RBF and pO 2 in clipped kidneys. In conclusion, only tempol effectively reduces MAP and increases RBF and pO 2 in the clipped kidneys in the chronic model of Goldblatt hypertension. These beneficial renal effects of tempol can not be achieved by conventional interventions directed to the renin‐angiotensin system.
Homologous and heterologous neutralization antibody responses after immunization with Japanese encephalitis vaccine among Taiwan children (1994)

Because 21 immunized children (13%) among the 162 confirmed Japanese encephalitis (JE) cases during 1986-1991 occurred in Taiwan, we collected 320 serum samples from Taiwan children aged 15-31 and 27-44 months immediately before the 1st dose (n = 41) and 1-3 months after the 2nd dose (n = 78, 27 pairs), and immediately before (n = 58) and 1-3 months after the 3rd dose (n = 143, 44 pairs) to determine neutralization antibody (Nt Ab) against the Nakayama (N) and Beijing-1 (B) strains and two Taiwan wild type JE viruses (JEV): CC-27 and CH-1392. Our Nt results showed that (1) B vaccine stimulated a better homologous Ab response than N vaccine for Nt Ab seropositivity rate (NASR), produced a higher level of Nt titer after the primary immunization [2 doses = 100% vs. 91%, geometric mean titer (GMT) = 115 vs. 22], had a greater booster effect (3 doses: 100% vs. 95%; GMT = 320 vs 33), and showed a better capability to neutralize two local Taiwan JEV strains, particularly only after 3 doses (ave. NASR for B vs. N = 90% vs. 10%; and GMT for B vs. N = 154 vs. 1); (2) the two wild type JEV strains had different plaque morphology and antigenic variation and the CC-27 strain was not neutralized as well as the CH-1392 strain after 3 doses of vaccine (BBB or NNN or NNB); and (3) 30% of the children had lost JEV Nt Ab one year after the 2nd dose of N vaccine and natural infection with JE virus did occur among those children after immunization. In conclusion, (1) three doses of mouse-brain vaccine are the minimum requirement to protect children against the local Taiwan JEV-, (2) the best strain for a JE vaccine depends on level of Nt Ab it induced, the molecular epidemiology and antigenic variation of the JEV in each local area; and (3) future vaccine must produce better B- and T-cell memory.
Power allocation tradeoffs in multicarrier authentication systems (2009)

Physical layer authentication techniques exploit signal characteristics to identify radios. We describe how multicarrier systems may use such techniques to stealthily authenticate while maintaining high levels of security and robustness. We show that with channel state information (CSI) at the transmitter and receiver, multicarrier authentication systems can further improve performance by carefully allocating the authentication power on each carrier.
Dynamic scheduling of concurrent tasks with cost performance trade-off (2000)

This paper addresses the run time task scheduling problem on a multiprocessor platform for embedded systems, where energy consumption is a major concern, as opposed to the traditional static and dynamic scheduling approaches. Our approach i n tends to combine the advantages of the low run time complexity o f the static scheduler and the exibility of the dynamic scheduler and to optimize the system energy consumption at run time based on precomputed costperformance Pareto curves. We have applied our method to an ADSL modem application and the result shows the e ectiveness of our method.
Conceptual Foundations (2015)

After reading the four main parts of the book, one naturally begins to think about what the broader implications of COBRA are and what lies ahead for this field. This fifth part of the text begins to address these issues. First we talk about the core values that the COBRA approach is based on. We delineate the educational values associated with the material and try to outline the background that is needed to practice in this field. We finish the book with a brainstorming chapter that discusses the broader implications of genome-scale models and how they are likely to affect the life sciences going forward.
A new pigment from Streptomyces lavendulae. (1987)

A saframycin-non-producing mutant of Streptomyces lavendulae IFM 1291 was found to produce a new tyrosine-derived indicator SL-1 pigment with anti-dermatophyte activity. The present paper describes the isolation, structural elucidation and biological properties, especially
An Alternative Chemical Route for the Synthesis and Thermal Stability of Chemically Enriched Hydroxyapatite (2005)

Hydroxyapatite (HAp: Ca 10 (PO 4 ) 6 (OH) 2 ) was synthesized by aqueous precipitation using CaCl 2 and Na 3 PO 4 with NaOH added to ensure completion of the reaction at room temperature. The HAp powder prepared using stoichiometric amounts of NaOH was stable even at 1200°C, but the HAp prepared with sub‐stoichiometric amounts of NaOH resulted in its transformation into β‐tricalcium phosphate at 600°C. The reaction pH, X‐ray diffraction, thermal analysis, scanning electron microscopy, Fourier transform infrared analyses and inductively coupled plasma‐optical emission spectroscopy were used to characterize the phase purity, thermal stability, morphology, and chemical composition of the synthesized HAp powder.
Cell Migration: Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy (Adv. Funct. Mater. 10/2009) (2009)

This work reports the design of and experimentation with a topographically patterned cell culture substrate of variable local density and anisotropy as a facile and efficient platform to guide the organization and migration of cells in spatially desirable patterns. Using UV-assisted capillary force lithography, an optically transparent microstructured layer of a UV curable poly(urethane acrylate) resin is fabricated and employed as a cell-culture substrate after coating with fibronectin. With variable local pattern density and anisotropy present in a single cell-culture substrate, the differential polarization of cell morphology and movement in a single experiment is quantitatively characterized. It is found that cell shape and velocity are exquisitely sensitive to variation in the local anisotropy of the two-dimensional rectangular lattice arrays, with cell elongation and speed decreasing on symmetric lattice patterns. It is also found that cells could integrate orthogonal spatial cues when determining the direction of cell orientation and movement. Furthermore, cells preferentially migrate toward the topographically denser areas from sparser ones. Consistent with these results, it is demonstrated that systematic variation of local densities of rectangular lattice arrays enable a planar assembly of cells into a specified location. It is envisioned that lithographically defined substrates of variable local density and anisotropy not only provide a new route to tailoring the cell-material interface but could serve as a template for advanced tissue engineering.