gebhart/patrepeval huggingface dataset:
Joint Task Offloading and Resource Allocation for Energy-Constrained Mobile Edge Computing (2022)

We consider the problem of task offloading and resource allocation in mobile edge computing (MEC). To maintain satisfactory quality of experience (QoE) of end-users, mobile devices (MDs) may offload their tasks to edge servers based on the allocated computation (e.g., CPU/GPU cycles and storage) and wireless resources (e.g., bandwidth). However, these resources could not be effectively utilized unless an encouraging resource allocation scheme can be proposed. What’s worse, task offloading incurs additional MEC energy consumption, which inevitably violate the long-term MEC energy budget. Considering these two challenges, we propose an online joint offloading and resource allocation (JORA) framework under the long-term MEC energy constraint, aiming at guaranteeing the end-users’ QoE. To achieve this, we leverage Lyapunov optimization to exploit the optimality of the long-term QoE maximization problem. By constructing an energy deficit queue to guide energy consumption, the problem can be solved in a real-time manner. On this basis, we propose online JORA methods in both centralized and distributed manners. Furthermore, we prove that our proposed methods enable the achievement of the close-to-optimal performance while satisfying the long-term MEC energy constraint. In addition, we conduct extensive simulations and the results show superiority in performance over other methods.
Elbow Arthroscopy (2014)

Elbow arthroscopy is a tool useful for the treatment of a variety of pathologies about the elbow. The major indications for elbow arthroscopy include débridement for septic elbow arthritis, synovectomy for inflammatory arthritis, débridement for osteoarthritis, loose body extraction, contracture release, treatment of osteochondral defects and selected fractures or instability, and tennis elbow release. Contraindications, technical considerations, and favorable outcomes following treatment with elbow arthroscopy require careful patient evaluation, a thorough understanding of anatomic principles, and proper patient positioning and portal selection to guide preoperative planning and overall patient care. Elbow arthroscopy is an effective procedure for the treatment of inflammatory arthritis, osteoarthritis, and lateral epicondylitis.
Supplementary Data from Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15<sup>+</sup> Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy (2023)

&lt;p&gt;Supplementary tables&lt;/p&gt;
Phase-Coherent Optical Pulse Synthesis from Separate Femtosecond Lasers (2001)

We generated a coherently synthesized optical pulse from two independent mode-locked femtosecond lasers, providing a route to extend the coherent bandwidth available for ultrafast science. The two separate lasers (one centered at 760 nanometers wavelength, the other at 810 nanometers) are tightly synchronized and phase-locked. Coherence between the two lasers is demonstrated via spectral interferometry and second-order field cross-correlation. Measurements reveal a coherently synthesized pulse that has a temporally narrower second-order autocorrelation width and that exhibits a larger amplitude than the individual laser outputs. This work represents a new and flexible approach to the synthesis of coherent light.
Rearrangement of optically active ethyl (E)-3-methyl-3-phenylglycidate. Evidence for concerted carbethoxy migration (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of optically active ethyl (E)-3-methyl-3-phenylglycidate. Evidence for concerted carbethoxy migrationJohn M. Domagala, Robert D. Bach, and James WempleCite this: J. Am. Chem. Soc. 1976, 98, 7, 1975–1977Publication Date (Print):March 1, 1976Publication History Published online1 May 2002Published inissue 1 March 1976https://pubs.acs.org/doi/10.1021/ja00423a061https://doi.org/10.1021/ja00423a061research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Torsional Stability of a Compressor Cascade (1991)

This paper includes new experimental data on the torsional stability of a compressor or fan type of blade row. This data is linked in with published material to form a three dimensional figure describing the stability of such rows. The data is then discussed by considering relative values of influence coefficients and some of the trends in the stability figure are explained. New data is also included on the relative magnitudes and phases of the influence coefficients.
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression (2022)

The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, some of which are therapeutically undesirable. This is especially the case for adenosine A<sub>1</sub> receptors (A<sub>1</sub>Rs) whose clinical potential is undermined by the sedation and cardiorespiratory depression caused by conventional agonists. We have discovered that the A<sub>1</sub>R-selective agonist, benzyloxy-cyclopentyladenosine (BnOCPA), is a potent and powerful analgesic but does not cause sedation, bradycardia, hypotension or respiratory depression. This unprecedented discrimination between native A<sub>1</sub>Rs arises from BnOCPA's unique and exquisitely selective activation of Gob among the six Gαi/o subtypes, and in the absence of β-arrestin recruitment. BnOCPA thus demonstrates a highly-specific Gα-selective activation of the native A<sub>1</sub>R, sheds new light on GPCR signalling, and reveals new possibilities for the development of novel therapeutics based on the far-reaching concept of selective Gα agonism.
ChemInform Abstract: Engineered Solid Catalysis for Synthesis of Fine Chemicals in Multiphasic Reactant Systems (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Propagation of pSC101 plasmids defective in binding of integration host factor (1992)

Integration host factor (IHF), a multifunctional protein of E. coli, normally is required for the replication of plasmid pSC101. T. T. Stenzel, P. Patel, and D. Bastia (Cell 49:709-717, 1987) have reported that IHF binds to a DNA locus near the pSC101 replication origin and enhances a static bend present in this region; mutation of the IHF binding site affects the plasmid's ability to replicate. We report here studies indicating that the requirement for IHF binding near the pSC101 replication origin is circumvented partially or completely by (i) mutation of the plasmid-encoded repA (replicase) gene or the chromosomally encoded topA gene, (ii) the presence on the plasmid of the pSC101 partition (par) locus, or (iii) replacement of the par locus by a strong transcriptional promoter. With the exception of the repA mutation, the factors that substitute for a functional origin region IHF binding site are known to alter plasmid topology by increasing negative DNA supercoiling, as does IHF itself. These results are consistent with the proposal that IHF binding near the pSC101 replication origin promotes plasmid replication by inducing a conformational change leading to formation of a repA-dependent DNA-protein complex. A variety of IHF-independent mechanisms can facilitate formation of the putative replication-initiation complex.
Does the calcein-AM method assay the total cellular ‘labile iron pool’ or only a fraction of it? (2007)

The calcein-AM (calcein-acetoxymethyl ester) method is a widely used technique that is supposed to assay the intracellular 'labile iron pool' (LIP). When cells in culture are exposed to this ester, it passes the plasma membrane and reacts with cytosolic unspecific esterases. One of the reaction products, calcein, is a fluorochrome and a hydrophilic alcohol to which membranes are non-permeable and which, consequently, is retained within the cytosol of cells. Calcein fluorescence is quenched following chelation of low-mass labile iron, and the degree of quenching gives an estimate of the amounts of chelatable iron. However, a requirement for the assay to be able to demonstrate cellular LIP in total is that such iron be localized in the cytosol and not in a membrane-limited compartment. For some time it has been known that a major part of cellular, redox-active, labile, low-mass iron is temporarily localized in the lysosomal compartment as a result of the autophagic degradation of ferruginous materials, such as mitochondrial complexes and ferritin. Even if some calcein-AM may escape cytosolic esterases and enter lysosomes to be cleaved by lysosomal acidic esterases, the resulting calcein does not significantly chelate iron at <pH 5. In the present study we show that the calcein-AM method does not capture lysosomal low-mass iron and, therefore, that the method seriously underestimates total cellular labile iron.
Study on surface properties of PDMS microfluidic chips treated with albumin (2009)

Electrokinetic properties and morphology of PDMS microfluidic chips intended for bioassays are studied. The chips are fabricated by a casting method followed by polymerization bonding. Microchannels are coated with 1% solution of bovine serum albumin (BSA) in Tris buffer. Albumin passively adsorbs on the PDMS surface. Electrokinetic characteristics (electro-osmotic velocity, electro-osmotic mobility, and zeta potential) of the coated PDMS channels are experimentally determined as functions of the electric field strength and the characteristic electrolyte concentration. Atomic force microscopy (AFM) analysis of the surface reveals a "peak and ridge" structure of the protein layer and an imperfect substrate coating. On the basis of the AFM observation, several topologies of the BSA-PDMS surface are proposed. A nonslip mathematical model of the electro-osmotic flow is then numerically analyzed. It is found that the electrokinetic characteristics computed for a channel with the homogeneous distribution of a fixed electric charge do not fit the experimental data. Heterogeneous distribution of the fixed electric charge and the surface roughness is thus taken into account. When a flat PDMS surface with electric charge heterogeneities is considered, the numerical results are in very good agreement with our experimental data. An optimization analysis finally allowed the determination of the surface concentration of the electric charge and the degree of the PDMS surface coating. The obtained findings can be important for correct prediction and possibly for robust control of behavior of electrically driven PDMS microfluidic chips. The proposed method of the electro-osmotic flow analysis at surfaces with a heterogeneous distribution of the surface electric charge can also be exploited in the interpretation of experimental studies dealing with protein-solid phase interactions or substrate coatings.
Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems (2017)

In the present work, new matrix bead formulations based on linear and branched polysaccharides have been developed using an ionic gelation technique, and their potential use as oral drug carriers has been evaluated. Using calcium chloride as a cross‐linking agent and sodium diclofenac (SD), as a model drug, acacia gum–calcium alginate matrix beads were formulated. The response surface methodology based on 3 2 factorial design was used as a statistical method to evaluate and optimize the effects of the biopolymers‐blend ratio and the concentration of calcium chloride on the particle size (mm), density (g/cm 3 ), drug encapsulation efficiency (%), and the cumulative drug release after 8 hours (R 8h ,%). The optimized beads with the highest drug encapsulation efficiency were examined for a drug‐excipients compatibility by powder X‐ray diffraction, differential scanning calorimetry, thermo‐gravimetric analysis, and Fourier transform‐infrared spectroscopy analyses. The swelling and degradation of the matrix beads were found to be influenced by the pH of medium. Higher degrees of swelling were observed in intestinal pH than in stomach pH. Accordingly, the drug release study showed that the amount of SD released from the acacia gum–calcium alginate beads was higher in intestinal pH than in stomach pH. Therefore, the in vitro drug release from the SD‐loaded beads appears to follow the controlled‐release (Hixson‐Crowell) pattern involving a case‐2 transport mechanism operated by swelling and relaxation of the polymeric blend matrix.
DNA-dependent nucleoside 5'-triphosphatase activity of the gene 4 protein of bacteriophage T7. (1983)

The gene 4 protein of bacteriophage T7 is both a primase and a helicase. In this paper, we present a detailed description of a third activity, single-stranded DNA-dependent nucleoside 5'-triphosphate hydrolysis, and show that this activity is coupled to the unidirectional translocation of the gene 4 protein on single-stranded DNA (Tabor, S., and Richardson, C.C. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 205-209). The competitive inhibitor of NTP hydrolysis, beta, gamma-methylene dTTP, is also a potent inhibitor of gene 4 protein-dependent, RNA-primed DNA synthesis; inhibition is not due to a direct inhibition of T7 DNA polymerase or RNA primer synthesis. We conclude that the energy derived from the hydrolysis of NTPs by the gene 4 protein is required for translocation of the protein to primase recognition sites. Measurement of the rates of hydrolysis of NTPs using a variety of DNAs of known structure and length support the unidirectional translocation of the gene 4 protein on single-stranded DNA. Duplex DNA, RNA, and single-stranded DNA coated with single-stranded DNA-binding protein do not serve as effectors for the nucleoside triphosphatase of the gene 4 protein. Kinetic data suggest that the gene 4 protein does not remain bound to newly synthesized oligoribonucleotide primers but continues to search for other primase recognition sites. Although all the predominant naturally occurring NTPs except rCTP are hydrolyzed by the gene 4 protein, the enzyme shows specificity for dTTP with a Km of 0.4 mM. In the accompanying paper (Matson, S.W., Tabor, S., and Richardson, C.C. (1983) J. Biol. Chem. 258, 14017-14024), we show that the hydrolysis of NTPs is also required for the protein to function as a helicase in duplex regions of DNA.
Data from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issue, we characterized copy number alterations in 191 breast tumors using dense single nucleotide polymorphism arrays and identified 1,747 genes with copy number gain organized into 30 amplicons. Amplicons were distributed unequally throughout the genome. Each amplicon had distinct enrichment pattern in pathways, networks, and molecular functions, but genes within individual amplicons did not form coherent functional units. Genes in amplicons included all major tumorigenic pathways and were highly enriched in breast cancer–causative genes. In contrast, 1,188 genes with somatic mutations in breast cancer were distributed randomly over the genome, did not represent a functionally cohesive gene set, and were relatively less enriched in breast cancer marker genes. Mutated and gained genes did not show statistically significant overlap but were highly synergistic in populating key tumorigenic pathways including transforming growth factor β, WNT, fibroblast growth factor, and PIP3 signaling. In general, mutated genes were more frequently upstream of gained genes in transcription regulation signaling than vice versa, suggesting that mutated genes are mainly regulators, whereas gained genes are mostly regulated. ESR1 was the major transcription factor regulating amplified but not mutated genes. Our results support the hypothesis that multiple genetic events, including copy number gains and somatic mutations, are necessary for establishing the malignant cell phenotype. [Cancer Res 2008;68(22):9532–40]&lt;/p&gt;&lt;/div&gt;
Nanosecond laser photolysis of 4,4′-bi-phenylbisazide in solution (1986)

The primary process in the photodecomposition of aromatic azide and in the relevant nitrene formation has been of major photochemical interest. Aromatic nitrene, the ground state of which is a triplet, is well known as a highly reactive Intermediate in various kinds of photochemical and thermal reaction. Azide and nitrene are also important from a practical viewpoint, since they are employed in photolithographic processes.
Distributed confidence-weighted classification on MapReduce (2013)

Explosive growth in data size, data complexity, and data rates, triggered by emergence of high-throughput technologies such as remote sensing, crowd-sourcing, social networks, or computational advertising, in recent years has led to an increasing availability of data sets of unprecedented scales, with billions of high-dimensional data examples stored on hundreds of terabytes of memory. In order to make use of this large-scale data and extract useful knowledge, researchers in machine learning and data mining communities are faced with numerous challenges, since the classification algorithms designed for standard desktop computers are not capable of addressing these problems due to memory and time constraints. As a result, there exists an evident need for development of novel, more scalable algorithms that can handle large data sets. In this paper we propose such method, named AROW-MR, a linear SVM solver for efficient training of recently proposed confidence-weighted (CW) classifiers. Linear CW models maintain a Gaussian distribution over parameter vectors, thus allowing a user to estimate, in addition to separating hyperplane between two classes, parameter confidence as well. The proposed method employs MapReduce framework to train CW classifier in a distributed way, obtaining significant improvements in both training time and accuracy. This is achieved through training of local CW classifiers on each mapper, followed by optimally combining local classifiers on the reducer to obtain aggregated, more accurate CW linear model. We validated the proposed algorithm on synthetic data, and further showed that AROW-MR algorithm outperforms the baseline classifiers on an industrial, large-scale task of Ad Latency prediction, with nearly one billion examples.
Development of Wettability Evaluation Technique Using Contact Angle Measuring Equipment in Soldering (2003)

溶融はんだの接触角をin-situで光学的に計測するたあに開発した技術を既存のぬれ性試験機 (メニスコグラフ試験機) に組み込むことで, 物性値 (接触角, 界面張力) による定量的なぬれ性評価・解析が可能なシステムを構築した。代表的な鉛フリーはんだであるSn-3.5Agのぬれ性評価に適用した結果, Sn-3.5AgとCuとのぬれ接触角 (θ) は43degと大きくSn-37Pb (θ=23deg) に比べてぬれ性に劣ることがわかった。さらに, ぬれ性に及ぼすSn-3.5Agへの元素添加 (1%Cu, 1%Zn, 5%Bi, 5%In) , フラックスおよびCu表面のAuコーティング処理の影響について検討し, 接触角の差異には, はんだ, 基板, フラックス間の界面張力の違いが起因することを明らかにした。
Detecting Clinically Relevant Emotional Distress and Functional Impairment in Children and Adolescents: Protocol for an Automated Speech Analysis Algorithm Development Study (2023)

DERR1-10.2196/46970.
Bidder Participation and Information in Currency Auctions (2005)

This Working Paper should not be reported as representing the views of the IMF.
Nanoporous Organic Polymer/Cage Composite Membranes (2012)

Organisch-organische Verbundmembranen werden durch In-situ-Kristallisation käfigförmiger molekularer Verbindungen in einem intrinsisch mikroporösen Polymer erhalten. Somit steht ein direkter Zugang zu gemischten Membranen offen, der von Molekülen in homogener Lösung ausgeht. Die Membranen verfügen über extrem hohe Gaspermeabilitäten (selbst nach einjähriger Lagerung) und gute Selektivitäten im Hinblick auf Anwendungen wie die CO2-Abscheidung. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Multifunctional Oxygen Scavenger Layer for High-Performance Oxide Thin-Film Transistors with Low-Temperature Processing (2021)

In this study, the oxygen scavenger layer (OSL) is proposed as a back channel in the bilayer channel to enhance both the electrical characteristics and stability of an amorphous indium-gallium-zinc oxide thin-film transistor (a-IGZO TFT) and also to enable its fabrication at low temperature. The OSL is a hafnium (Hf)-doped a-IGZO channel layer deposited by radio-frequency magnetron cosputtering. Amorphous IGZO TFTs with the OSL, even if annealed at a low temperature (200 °C), exhibited improved electrical characteristics and stability under positive bias temperature stress (PBTS) compared to those without the OSL, specifically in terms of field-effect mobility (31.08 vs 9.25 cm<sup>2</sup>/V s), on/off current ratio (1.73 × 10<sup>10</sup> vs 8.68 × 10<sup>8</sup>), and subthreshold swing (0.32 vs 0.43 V/decade). The threshold voltage shift under PBTS at 50 °C for 10,000 s decreased from 9.22 to 2.31 V. These enhancements are attributed to Hf in the OSL, which absorbs oxygen ions from the a-IGZO front channel near the interface between a-IGZO and the OSL.
Ultra-High Bandwidth Integrated Lithium Niobate Modulators with Record-Low Vπ (2018)

We demonstrate integrated lithium niobate electro-optic modulators with up to 100-GHz electro-optic bandwidth and V π as low as 1.4 V. We show 70 GBaud and 100 GBaud m-ASK modulation with the fabricated modulator.