gebhart/patrepeval huggingface dataset:
Supplementary Figure 1 from Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer (2023)

&lt;p&gt;PDF file - 39K, Fifty-nine samples from the NCI-60 cell panel were RMA normalized and base on 3D principal components analysis, MCF-7 was ommitted from further analysis.&lt;/p&gt;
Surface photochemistry: the effect of surface modification on the photophysics of naphthalene and pyrene adsorbed on silica gel (1984)

The influence of heat treatment and of added coadsorbates on the surface photophysics of pyrene and naphthalene adsorbed on silica gel is reported. When the silica gel surface is partially dehydroxylated, the distribution of pyrene or naphthalene is inhomogeneous, as indicated by multiexponential fluorescence decay and broad emission spectra. Addition of polar coadsorbates renders the surface more homogeneous with singlet lifetimes approaching solution values. The pretreatment and addition of coadsorbates, in the case of pyrene, also influence the relative importance of dynamic excimer formation vis-a-vis ground state association.
Supplementary table 4 from <i>WRN</i> Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy (2023)

&lt;p&gt;Multivariate Cox regression analysis showing the relationship between different covariates,including an interaction between WRN methylation and treatment arm, and progression free survival&lt;/p&gt;
[Strategies of nutrients control in lakes based on ecoregions of lakes in China]. (2013)

In order to better reduce lake eutrophication, based on five ecoregions of lakes, the relationships of total nitrogen (TN), total phosphorus (TP), and TN/TP ratio with chlorophyll-a (Chl-a) in 100 lakes were discussed, furthermore, strategies of nutrient control were proposed respectively. Results showed that among the five ecoregions, the lake eutrophication level was the lowest in Dongbei ecoregion and the highest in Huabei ecoregion, but the eutrophication level in lakes of all the five ecoregions is increasing in recent years. Algal growth in lakes of Dongbei and Huabei ecoregions was limited by phosphorus, while it was simultaneously limited by nitogen and phosphorus in lakes of other three ecoregions (Zhongdongbu, Yungui and Mengxin). In lakes with TN/TP < 10, significant correlation between Chl-a concentration and TN was found in lakes of the five ecoregions except for Huabei ecoregion, and significant correlation between Chl-a concentration and TP was found in lakes of Dongbei and Mengxin ecoregions. In lakes with TN/TP > 17, significant correlation between Chl-a concentration and TP was found in lakes of the five ecoregions except for Mengxin ecoregion, and significant correlation between Chl-a concentration and TN was found in lakes of Zhongdongbu, Yungui and Mengxin ecoregions. In lakes with 10 < TN/TP < 17, no significant correlation between Chl-a and TN (or TP) was found in lakes of all ecoregions except for Zhongdongbu ecoregion where Chl-a concentration was significantly affected by TN. As for strategies of nutrient control and reduction in the five ecoregions, lakes of Huabei ecoregion should adopt TP control in priority, and in Dongbei ecoregion, TP and TN should be controlled simultaneously in lakes with TN/TP < 10, while other lakes should focus on TP control. Lakes in other three ecoregions (Zhongdongbu, Mengxin and Yungui) should control TP and TN simultaneously.
New methods for bounding the number of points on curves over finite fields (2012)

We provide new upper bounds on N_q(g), the maximum number of rational points on a smooth absolutely irreducible genus-g curve over F_q, for many values of q and g. Among other results, we find that N_4(7) = 21 and N_8(5) = 29, and we show that a genus-12 curve over F_2 having 15 rational points must have characteristic polynomial of Frobenius equal to one of three explicitly given possibilities. We also provide sharp upper bounds for the lengths of the shortest vectors in Hermitian lattices of small rank and determinant over the maximal orders of small imaginary quadratic fields of class number 1. Some of our intermediate results can be interpreted in terms of Mordell-Weil lattices of constant elliptic curves over one-dimensional function fields over finite fields. Using the Birch and Swinnerton-Dyer conjecture for such elliptic curves, we deduce lower bounds on the orders of certain Shafarevich-Tate groups.
Evaluating Genetic Counseling for Individuals With Schizophrenia in the Molecular Age (2012)

These results provide initial evidence of need for, and efficacy of, genetic counseling for individuals with schizophrenia. The findings may help facilitate development of a contemporary genetic counseling process that could optimize outcomes in the nascent field of evidence-based psychiatric genetic counseling.
A resilience roadmap (2010)

Technology scaling has an increasing impact on the resilience of CMOS circuits. This outcome is the result of (a) increasing sensitivity to various intrinsic and extrinsic noise sources as circuits shrink, and (b) a corresponding increase in parametric variability causing behavior similar to what would be expected with hard (topological) faults. This paper examines the issue of circuit resilience, then proposes and demonstrates a roadmap for evaluating fault rates starting at the 45 nm and going down to the 12 nm nodes. The complete infrastructure necessary to make these predictions is placed in the open source domain, with the hope that it will invigorate research in this area.
Acute adrenal failure as presenting feature of antiphospholipid syndrome (2020)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Alignment and Integration of a Hybrid, External-Cavity InP-SOI Laser (2016)

A 1550nm external-cavity hybrid III-V/SOI laser with a room-temperature threshold current of 18mA and output powers up to 4mW was demonstrated with a novel assembly technique. An edge-coupled 1x6 laser array was passively aligned with sub-micron positional tolerance.
The genetic control of virulence in group A streptococci. III. Plasmid-induced "switch-off"--effect on some pathogenic properties. (1984)

Recently, we reported that conjugal transfer of plasmid pERL1, determining i.a. erythromycin resistance (Emr), into group A streptococci could trigger the expression of anti-phagocytic activity, adhesiveness, opacity factor and capacity to bind immunoglobulin Fc-parts and beta 2-microglobulin. In the present study, ethidium bromide treatment of Emr transconjugants allowed the selection of "cured", erythromycin sensitive (Ems) mutants. This procedure did not affect the expression of the abovementioned characteristics. However, when plasmid pERL1 was again transferred to two such mutants, the "secondary", Emr transconjugants obtained showed lack of each of these properties. Our experiments thus demonstrated a "switch-on" as well as a "switch-off" effect, exerted by the same plasmid, pERL1, on some major pathogenic properties of group A streptococci.
Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes. (1987)

Platelet membrane glycoprotein IIb-IIIa forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. GPIIIa is a single chain protein. These proteins are synthesized in the bone marrow by megakaryocytes, but the study of their synthesis has been hampered by the difficulty in obtaining enriched population of megakaryocytes in large numbers. To examine the biosynthesis and processing of GPIIb-IIIa, purified human megakaryocytes were isolated from liquid cultures of cryopreserved leukocytes stem cell concentrates from patients with chronic myelogenous leukemia. Immunoprecipitation of [35S]methionine pulse-chase-labeled cell extracts by antibodies specific for the alpha or beta subunits of GPIIb indicated that GPIIb was derived from a precursor of Mr 130,000 that contains the alpha and beta subunits. This precursor was converted to GPIIb with a half-life of 4-5 h. No precursor form of GPIIIa was detected. The glycosylation of GPIIb-IIIa was examined in megakaryocytes by metabolic labeling in the presence of tunicamycin, monensin, or treatment with endoglycosidase H. The polypeptide backbones of the GPIIb and the GPIIIa have molecular masses of 120 and 90 kD, respectively. High-mannose oligosaccharides are added to these polypeptide backbones co-translationally. The GPIIb precursor is then processed with conversion of high-mannose to complex type carbohydrates yielding the mature subunits GPIIb alpha (Mr 116,000) and GPIIb beta (Mr 25,000). No posttranslational processing of GPIIIa was detected.
Chiral charge-density wave in TiSe$_2$ due to photo-induced structural distortions (2020)

A variety of experiments have been carried out to establish the origin of the chiral charge-density wave transition in 1T-TiSe$_2$, which in turn has led to contradictory conclusions on the origin of this transition. Some studies suggest the transition is a phonon-driven structural distortion while other studies suggest it is an excitonic insulator phase transition that is accompanied by a lattice distortion. First, we propose these interpretations can be reconciled if one analyzes the available experimental and theoretical data within a formal definition of what constitutes an excitonic insulator as initially proposed by Keldysh and Kopaev. Next, we present pump-probe measurements of circularly polarized optical transitions and first-principles calculations where we highlight the importance of accounting for structural distortions to explain the finite chirality of optical transitions in the CDW phase. We show that at the elevated electronic temperature that occurs upon photoexcitation, there is a non-centrosymmetric structure that is near-degenerate in energy with the centrosymmetric charge density wave structure, which explains the finite chirality of the optical transitions observed in the CDW phase of TiSe$_2$.
THE INFRARED SPECTRA OF THE OCTAHEDRAL COMPLEXES OF IRON(II), COBALT(II) AND NICKEL(II) WITH BIACETYL-BIS-METHYLIMINE AND PYRIDINAL METHYLIMINES (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE INFRARED SPECTRA OF THE OCTAHEDRAL COMPLEXES OF IRON(II), COBALT(II) AND NICKEL(II) WITH BIACETYL-BIS-METHYLIMINE AND PYRIDINAL METHYLIMINESPaul E. Figgins and Daryle H. BuschCite this: J. Phys. Chem. 1961, 65, 12, 2236–2240Publication Date (Print):December 1, 1961Publication History Published online1 May 2002Published inissue 1 December 1961https://pubs.acs.org/doi/10.1021/j100829a033https://doi.org/10.1021/j100829a033research-articleACS PublicationsRequest reuse permissionsArticle Views408Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Functional allelic loss detected at the protein level in archival human tumours using allele‐specific E‐cadherin monoclonal antibodies (2002)

Immunohistochemical analysis has been used to show that expression of the homophilic cell-to-cell adhesion molecule, E-cadherin, is frequently altered in human cancers, including gastric and breast carcinoma. Besides genetic down-regulation, structural mutations such as in-frame deletions of exon 8 and exon 9 were frequently found; these may affect the binding of monoclonal antibodies used for immunohistochemical analysis. In this study it was found that antibodies HECD-1 and E9, two monoclonal antibodies often used in E-cadherin immunoanalysis, react with epitopes present at least in part in exon 8 and exon 9, respectively. This study generated and characterized a mutation-specific monoclonal antibody, E-cad delta 8-1, reacting with the mutant protein lacking exon 8 but not with the wild-type molecule. By using E-cad delta 8-1 and HECD-1, it was possible separately to analyse the immunoreactivity of mutant and normal E-cadherin proteins, respectively, in an allele-specific manner in archival material. A similar analysis was performed using E9 and the previously characterized mutation-specific antibody E-cad delta 9-1. Typically, in gastric and breast cancer harbouring E-cadherin splice site gene mutations, the mutant proteins were expressed but the wild-type protein was not detected in malignant tissues. These results indicate that variant-specific monoclonal antibodies can be used to identify differentially expressed E-cadherin proteins. For immunohistochemical analysis of E-cadherin, at least two different monoclonal antibodies should be used to exclude alterations of the epitopes resulting in failure to detect a mutant protein.
HCI as an Inter-Discipline (2015)

This paper responds to a 2014 paper by Liu et al seeking a quantifiable thematic core to CHI. As an alternative, I argue that CHI should strategically avoid the search for such a core, instead seeking its identity as a mode of responding and contributing to other disciplines.
Hypothalamic Actions of Apelin on Energy Metabolism: New Insight on Glucose Homeostasis and Metabolic Disorders (2013)

Hypothalamus is key area implicated in control of glucose homeostasis. This structure integrates nervous and peripheral informations to adapt a response modifying peripheral glucose utilization and maintaining energetic balance. Among peripheral signals, adipokines such as adiponectin and leptin are of special importance since deregulations of their actions are closely associated to metabolic disorders such as obesity and type 2 diabetes. During the past ten years, we have identified a new adipokine named apelin which has emerging role in the control of metabolism. The originality of the apelinergic system is to be largely represented in peripheral tissues (adipose tissue, intestine, etc.) and in the brain. Then, apelin is released by adipose tissue as all adipokines, but also present another crucial role as neurotransmitter in hypothalamic neurons. By acting in the whole body, apelin exerts pleiotropic actions and is now considered as a major determinant of physiological functions. Besides its general beneficial effects on peripheral targets, central action of apelin remains still a matter of debate. In this review, we have made a parallel between peripheral vs. central actions of apelin in term of signalization and effects. Then, we have focused our attention on hypothalamic apelin and its potential role in glucose metabolism and associated pathologies.
A parallel feature tracker for extended image sequences (2002)

This paper presents a feature tracker for long image sequences based on simultaneously estimating die motions and deformations of a collection of adjacent image patches. By sharing common corner nodes, the patches achieve greater stability than independent patch trackers. Modeling full bilinear deformations enables tracking in sequences which have large non-translational motions and/or foreshortening effects. We demonstrate the advantages of our technique with respect to previous algorithms using experimental results.
Safe and Scalable Real-Time Trajectory Planning Framework for Urban Air Mobility (2023)

This paper presents a real-time trajectory planning framework for Urban Air Mobility (UAM) that is both safe and scalable. The proposed framework employs a decentralized, free-flight concept of operation in which each aircraft independently performs separation assurance and conflict resolution, generating safe trajectories by accounting for the future states of nearby aircraft. The framework consists of two main components: a data-driven reachability analysis tool and an efficient Markov Decision Process (MDP) based decision maker. The reachability analysis over-approximates the reachable set of each aircraft through a discrepancy function learned online from simulated trajectories. The decision maker, on the other hand, uses a 6-degrees-of-freedom guidance model of fixed-wing aircraft to ensure collision-free trajectory planning. Additionally, the proposed framework incorporates reward shaping and action shielding techniques to enhance safety performance. The proposed framework is evaluated through simulation experiments involving up to 32 aircraft in a UAM setting, with performance measured by the number of Near Mid Air Collisions (NMAC) and computational time. The results demonstrate the safety and scalability of the proposed framework.
Cyclooxygenase-2 (COX-2) Levels Before and After Chemotherapy: A Study in Rectal Cancer (2005)

COX-2 induction was seen with CRT in this population of rectal cancer patients. Prognostic significance of this induction remains to be defined in a larger cohort.
Utilization of the Rat as a Model of Mammalian Aging: Impact of Pathology on Behavior (1996)

Because pathology is concomitant to aging in rat strains, extraneous variance can be added to studies of aging at all levels of analysis. Thus, several gerontologists have made recent requests for characterization of pathology in aging studies including not only investigators' reports of diseases commonly observed (e.g., Sendai virus) and the occurrence of prevalent age-related lesions (e.g., nephropathy, leukemia, radiculoneuropathy) in rodent colonies, but also how specific disease processes might impact on the variable of interest in their investigation. Reported here are simple techniques (e.g., physical examination, necropsy to identify lesions, hematocrit, Wright stain) used routinely by our laboratory to screen for the presence of age-related disease in studies using Fischer 344 and Wistar rats. Routine health screening by physical examination and blood testing in our studies has allowed us either to eliminate moribund rats or to assess whether deficient performance was related to health status when these animals had been included in behavioral investigations. Additional health screens (e.g., antibodies for specific tumors) need to be developed. Investigators should be encouraged to utilize existing techniques, such as those reported here, and new technologies either to screen moribund animals from studies or to demonstrate that the pathology observed does or does not impact on the variable under investigation.
Skyrmion lattice hosted in synthetic antiferromagnets and helix modes (2022)

Thin ferromagnetic films can possess unconventional magnetic properties, opening a new road for using them in spintronic technologies. In the present work exploiting three different methods, we comprehensively analyze phason excitations of a skyrmion lattice in synthetic antiferromagnets. To analyze phason excitations of the skyrmion lattice, we have constructed an analytical model based on three coupled helices and found a linear gapless mode. Micromagnetic simulations also support this result. Moreover, a similar result has been achieved within the rigid skyrmion lattice model based on the coupled Thiele's equations, when the coupling between skyrmions in different layers of the synthetic antiferromagnetic is comparable to or larger than the intralayer coupling. In addition, we also consider the orbital angular momentum and spin pumping current associated with phason excitations. Due to the gapless excitations in the case of skyrmion lattice, the pumping current is nonzero for the arbitrary frequency of pumping microwaves. In the case of individual skyrmions, no current is pumped when microwave frequency is inside the gap of the spectrum of individual skyrmions.
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results (2014)

Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two wellknown drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 and CB2 cannabinoid and μ opioid receptors. In [(35)S]-GTPγS (guanosine 5'-O-[gamma-thio]triphosphate) binding assays from the post-mortem human frontal cortex, they proved to be CB1 cannabinoid antagonists and μ opioid antagonists. Interestingly, in vivo, the new compounds exhibited a significant dual antagonist action on the endocannabinoid and opioid systems.
SMOS after 2 years in orbit: challenges, issues and results (2012)

International audience
Pregnancy‐Specific Glycoprotein Gene Expression in Recurrent Aborters: A Potential Correlation to Interleukin‐10 Expression (1999)

The level of expression of the PSG11 gene in the uterine endometrium, during the peri-implantation period, correlates with the risk of pregnancy loss in some women experiencing recurrent spontaneous abortions. The ability of PSG11 to influence the secretion of IL-10 suggests that PSG11 may contribute to the local modulation of the inflammatory T helper-1 response seen in the endometrium of these women.
A Unique Growth Factor in Patients with Acromegaloidism* (1983)

Acromegaloidism is a syndrome characterized by features of acromegaly without biochemical evidence of excessive GH or somatomedin production. We searched for a growth factor in the serum of patients with this syndrome. Growth-promoting activity was measured by determining the stimulatory effect of whole and fractionated serum on colony formation by human erythroid progenitors in vitro. Sera from five subjects with acromegaloidism gave a mean (+/- SEM) stimulated colony growth of 211 +/- 4.0 colonies, in contrast to normal sera which yielded a mean colony growth of 100 +/- 11.0 (n = 9; P less than 0.001). When serum was chromatographed on a Sephadex G-200 column, the maximal stimulation of colony growth was found in the fractions coinciding with the descending slope of the second protein peak. Based on gel filtration chromatography, the estimated molecular weight was 70,000 daltons. Epidermal growth factor, nerve growth factor, fibroblast growth factor, and platelet-derived growth factor resulted in no substantial stimulation of colony growth under the conditions used. Although the erythroid progenitor cells of a Laron dwarf were unresponsive to 200 ng/ml human GH, they were clearly stimulated by serum from a patient with acromegaloidism. The present study describes the presence of a heretofore unidentified growth factor in the serum of subjects with acromegaloidism. This factor also stimulated the erythroid precursor cells of a Laron dwarf whose cells were unresponsive to GH. The physiological role of this growth factor in normal man as well as its pathogenic role in subjects with acromegaloidism remain to be established.
Attitudes of handicapped and nonhandicapped university students on three attitude scales. (1978)

AUTHOR Lazar, Alfred L.; And Others TITLE Attitudes of Handicapped and Non-Handicapped University Students on Three Attitude Scales. INSTITUTION California State Univ., Long Beach. Dept. of Educational Psychology. SPONS AGENCY Bureau of Education for the Handicapped (DHEW/OE), Washington, D.C. PUB DATE 76 GRANT GOO-74-02794 NOTE 22p.; Paper presented at the Annual Conference of the California Educational Research Association (55the Burlingame, California, November 18-19, 1976)