gebhart/patrepeval huggingface dataset:
Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight (2019)

The presence of Grade 2-3 steatosis on ultrasound in early pregnancy was associated with the increased risk of delivering an LGA infant, even after adjustment for multiple confounding factors including GDM. Adiponectin may be the linking biomarker between NAFLD and LGA.
Distributed development considered harmful? (2013)

We offer a case study illustrating three rules for reporting research to industrial practitioners. Firstly, report “relevant” results; e.g. this paper explores the effects of distributed development on software products. Second: “recheck” old results if new results call them into question. Many papers say distributed development can be harmful to software quality. Previous work by Bird et al. allayed that concern but a recent paper by Posnett et al. suggests that the Bird result was biased by the kinds of files it explored. Hence, this paper rechecks that result and finds significant differences in Microsoft products (Office 2010) between software built by distributed or collocated teams. At first glance, this recheck calls into question the widespread practice of distributed development. Our third rule is to “reflect” on results to avoid confusing practitioners with an arcane mathematical analysis. For example, on reflection, we found that the effect size of the differences seen in the collocated and distributed software was so small that it need not concern industrial practitioners. Our conclusion is that at least for Microsoft products, distributed development is not considered harmful.
Oxidative coupling of methane with soft oxidants: Mechanistic insights from combined experiment and theory (2020)

Macromolecular Chemistry: The Second Century [Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing) [How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf) [Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)
SLANT/PRISM Convertible Structured Color Processor MN5515 (1995)

Color image reproduction in hard copy becomes more precious by recent progress of color input/output devices and image processing technologies. Especially in printing devices, its imaging characteristics in color reproduction deeply depend on printing devices and so various technologies of image processing are developed individually. Recent approach of device independent color reproduction or idea of color management systems needs common color processing method. We developed a new color processor LSI that has 3D-LUT and newly designed SLANT-PRISM interpolator suitable for those requirements and useful for various kinds of color conversion and color management system.
Real Time Ultrasound Molecular Imaging of Prostate Cancer with PSMA-targeted Nanobubbles (2019)

Abstract Contrast-enhanced ultrasound with microbubbles has shown promise in detection of prostate cancer (PCa), but sensitivity and specificity of detection remain challenging. Targeted nanoscale contrast agents with improved capability to accumulate in tumors may result in prolonged signal enhancement and improved detection of PCa with ultrasound. Here we report on a new nanobubble contrast agent that specifically targets prostate specific membrane antigen (PSMA) overexpressed in most prostate tumors. The PSMA-targeted bubbles (PSMA-NB) were utilized to simultaneously image dual flank PCa tumors (PSMA-positive PC3pip and PSMA-negative PC3flu) to examine whether the biomarker can be successfully detected and imaged using this probe in a mouse model. Results demonstrate that active targeting of NBs to PSMA rapidly and selectively enhances tumor accumulation and is critical for tumor retention of the contrast agent. Importantly, these processes could be visualized and quantified, in real time, with standard clinical ultrasound. Such demonstration of the immense yet underutilized potential of ultrasound in the area of molecular imaging can open the door to future opportunities for improving sensitivity and specificity of cancer detection using parametric NB-enhanced ultrasound imaging.
High performance 3.3- and 5-V 0.5-μm CMOS technology for ASIC's (1995)

Process integration of two manufacturable high performance 0.5-/spl mu/m CMOS technologies, one optimized for 5.0 V operation and the second optimized for 3.3-V operation, will be presented. The paper will emphasize poly-buffered LOGOS (PBL) isolation, MOS transistor design using conventional and statistical modeling to reduce circuit performance sensitivity to process fluctuations, gate oxide and gate length control, and hot carrier reliability of the transistors. Manufacturing and simulation data for both 3.3- and 5.0-V technologies will be shown. The nominal ring oscillator delay is measured for both 3.3- and 5.0-V technologies as 80 ps. Therefore, 5.0-V technology equivalent speed is achieved in the 3.3-V technology with a reduction in power consumption by a factor of 2.4.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cerebrovascular Dynamics of Autoregulation and Hypoperfusion (1999)

Parenchymal CBV changes are smaller than those of previous reports but are consistent with the small arteriolar fraction of total blood volume. Such measurements allow a framework for understanding effective compensatory vasodilation during autoregulation and volume-flow relationships during hypoperfusion.
Effects of Threading Dislocations on AlGaN/GaN High-Electron Mobility Transistors (2009)

This brief aims to show the effects of threading edge dislocations on the DC and RF performance of GaN high-electron mobility transistor (HEMT) devices. A state-of-the-art high-frequency and high-power HEMT was investigated with our full-band cellular Monte Carlo (CMC) simulator, which includes the full details of the band structure and the phonon spectra. A complete characterization of the device has been performed using experimental data to calibrate the few adjustable parameters of the simulator. Thermal simulations were also carried out with commercial software in order to operate the corrections needed to model thermal effects. The approach of Weimann based on the results of Read, Bonch-Bruevich and Glasko, and Po¿do¿r was then used to model with our CMC code the dislocation effects on the transport properties of HEMT devices. Our simulations indicate that GaN HEMT performance exhibits a fairly large dependence on the density of thread dislocation defects. Furthermore, we show that a threshold concentration exists, above which a complete degradation of the device operation occurs.
Unusual Mode of Binding of Human Group IIA Secreted Phospholipase A2 to Anionic Interfaces as Studied by Continuous Wave and Time Domain Electron Paramagnetic Resonance Spectroscopy (2002)

Human group IIA phospholipase A(2) (hGIIA) is secreted from a number of cells during inflammation and is known to interact strongly with anionic membranes and to exhibit potent Gram-positive bactericidal activity. This protein contains 23 cationic residues, which are scattered over its entire surface, resulting in a high pI of 9.39. To understand the molecular basis for the selective binding of hGIIA to anionic membranes, 14 single-site, spin-labeled hGIIA proteins were analyzed in the presence and absence of vesicles of anionic phospholipid by time domain and continuous wave electron paramagnetic resonance (EPR) spin relaxant techniques. Surprisingly, for hGIIA bound to anionic vesicles, all of the spin labels were highly protected from water-soluble spin relaxants. Together with light scattering studies, these EPR results suggest the formation of a supramolecular aggregate involving clusters of hGIIA molecules bridging together multiple vesicles. This anomalous mode of binding of hGIIA to anionic phospholipid explains previous data in which charge reversal mutation of a few cationic residues on multiple faces of hGIIA leads to a comparable and modest reduction in affinity of the protein for anionic vesicles. In the presence of mixed micelles composed of 10% anionic phospholipids in Triton X-100 a monodisperse protein-lipid complex is formed. Under these conditions, the EPR methods were used to map the surface of hGIIA that constitutes the interfacial binding site (IBS). The IBS of hGIIA consists of the highly hydrophobic surface that surrounds the opening to the active site slot.
Recent development in the HMR pre-combustion gas power cycle (2009)

The focus area of the current HMR phase has been HMR process engineering and fabrication and testing of a small-scale monolith module. A new, less complicated HMR gas power cycle has been developed and benchmarked. The efficiency loss and CO2 capture are typically 8 %-point and 85 %, respectively, but more than 90 % of the installed membrane area of the original concepts is rendered superfluous. Small-scale monolith modules have been fabricated and tested under real HMR process conditions, demonstrating promising hydrogen flux and steam reforming according to equilibrium.
Performance comparison of integrated z-axis frame microgyroscopes (2003)

This paper describes two different integrated surface-micromachined z-axis frame gyros fabricated side by side on a single chip for performance comparison. Frame microgyros; using an 'Inside Sense Outside Drive (ISOD)' and an 'Inside Drive Outside Sense (IDOS)' suspension designs were fabricated in the Analog Devices Modular-MEMS process using 6 /spl mu/m thick polysilicon as the structural material co-fabricated with a 0.8 /spl mu/m CMOS process. Initial characterization of these gyros suggest the ISOD frame gyro has a factor of three lower quadrature and Coriolis offset and a factor of five lower noise floor (limited by electronic noise) in comparison with the IDOS frame gyro. The surface-micromachined z-axis ISOD frame gyro exhibited a noise floor of 0.01/spl deg//s//spl radic/Hz and a scale factor of 1.5 mV//spl deg//s at 70 milli-Torr pressure.
Microtubules from Fluorinated Phosphorylated Amphiphiles in Aqueous/Alcoholic and Non-Aqueous Solvents (1996)

Abstract Phospholipids are known to self-organize into bilayer membranes and liposomes. Recently, much attention has also been focussed on highly ordered cylindrical, bilayer-based hollow microstructures usually called tubules, that form, for example, from diacetylenic phosphatidylcholines [1]. However, despite the potential of these new supramolecular architectures in both fundamental and applied area, only few tubule-forming surfactants have been reported yet. We have shown that the driving force required to form and stabilize coiled membranes in water can be brought by fitting amphiphiles with a single fluorinated chain, without need for rigid segments, hydrogen bonding between polar head or chiral centers [2,3].
Core-Core Dynamics in Spin Vortex Pairs (2012)

We investigate nanopillars in which two thin ferromagnetic particles are separated by a nanometer thin nonmagnetic spacer and can be set into stable spin vortex-pair configurations. We find that the previously unexplored limit of strong vortex core-core coupling can dominate the spin dynamics in the system. We observe experimentally and explain analytically and numerically how the 0.2 GHz gyrational resonance modes of the individual vortices are transformed into a 2 GHz collective rotational resonance mode in the configurations where the two cores form a bound pair.
Design and VLSI Implementation for a WCDMA (2005)

The third generation (3G) of cellular communications standards is based on wideband CDMA. The wideband signal ex- periences frequency selective fading due to multipath propagation. To mitigate this effect, a RAKE receiver is typically used to coher- ently combine the signal energy received on different multipaths. An effective multipath searcher is, therefore, required to identify the delayed versions of the transmitted signal with low probability of false alarm and misdetection. This paper presents an efficient and novel WCDMA multipath searcher design and VLSI archi- tecture that provides a good compromise between complexity, per- formance, and power consumption. Novel multipath searcher al- gorithms such as time domain interleaving and peak detection are also presented. The proposed searcher was implemented in 0.18 m CMOS technology and requires only 150 k gates for a total area of 1.5 mm consuming 6.6 mw at 100 MHz. The functionality and performance of the searcher was verified under realistic con- ditions using a channel emulator.
Biological activities of leukotriene derivatives and development of leukotriene antagonist. (1987)

Slow Reacting Substances of Anaphylaxis (SRS-A) which comprises of leukotrienes C4, D4 and E4 plays an important role in eliciting the symptoms of asthma. Since the discovery of the leukotrienes, many analogs have been synthesized in order to explore the relationships between the structure and biological activities.This review will focus on the leukotriene derivatives and the development of leukotriene antagonists.
[New diagnostic tools in lung cancers]. (2009)

The diagnostic of lung cancer mainly relies on thoracic CT scan and bronchoscopic techniques. During the past decade, several improvements of these diagnostic tools have been made available, which aim to decrease the time to diagnosis and to simplify the initial staging approach. The diagnostic of peripheral lung nodules takes advantage of FDG PET-CT imaging as well as of recent per-endoscopic methods of peripheral lung nodule sampling such as electromagnetic navigation and endobronchial ultrasound. Autofluorescence or narrow band imaging bronchoscopy are helpful for the early diagnostic and monitoring of superficial cancers of the proximal bronchial tree. The diagnostic of intra-mediastinal lymph nodes has been simplified by the use of endobronchial ultrasound--transbronchial needle aspiration. In the near future, these techniques should reduce the need for invasive surgical procedures during lung cancer staging.
Word-Based Adaptive OCR for Historical Books (2009)

The aim of this work is to propose a new approach to the recognition of historical texts by providing an adaptive mechanism that automatically tunes itself to a specific book. The system is based on clustering together all the similar words in a book/text and simultaneously handling entire class. The paper describes the architecture of such a system and new algorithms that have been developed for robust word image comparison (including registration, optical flow based distortion compensation, and adaptive binarization). Results for a large dataset are presented as well. Over 23% recognition improvement is demonstrated.
A New Class of Autopoietic and Cognitive Machines (2022)

Making computing machines mimic living organisms has captured the imagination of many since the dawn of digital computers. However, today’s artificial intelligence technologies fall short of replicating even the basic autopoietic and cognitive behaviors found in primitive biological systems. According to Charles Darwin, the difference in mind between humans and higher animals, great as it is, certainly is one of degree and not of kind. Autopoiesis refers to the behavior of a system that replicates itself and maintains identity and stability while facing fluctuations caused by external influences. Cognitive behaviors model the system’s state, sense internal and external changes, analyze, predict and take action to mitigate any risk to its functional fulfillment. How did intelligence evolve? what is the relationship between the mind and body? Answers to these questions should guide us to infuse autopoietic and cognitive behaviors into digital machines. In this paper, we show how to use the structural machine to build a cognitive reasoning system that integrates the knowledge from various digital symbolic and sub-symbolic computations. This approach is analogous to how the neocortex repurposed the reptilian brain and paves the path for digital machines to mimic living organisms using an integrated knowledge representation from different sources.
Structured sparsity through reweighting and application to diffusion MRI (2015)

We consider the problem of multiple correlated sparse signals reconstruction and propose a new implementation of structured sparsity through a reweighting scheme. We present a particular application for diffusion Magnetic Resonance Imaging data and show how this procedure can be used for fibre orientation reconstruction in the white matter of the brain. In that framework, our structured sparsity prior can be used to exploit the fundamental coherence between fibre directions in neighbour voxels. Our method approaches the ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> minimisation through a reweighted ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -minimisation scheme. The weights are here defined in such a way to promote correlated sparsity between neighbour signals.
CCR4 Expression by Atypical T Cells in Systemic Pilotropic Lymphoma: Its Behavior under Treatment with Interferon Gamma, Topical PUVA and Systemic Retinoid (2004)

We describe an 88-year-old Japanese patient with pilotropic T cell lymphoma involving the peripheral blood as well as lymph nodes. This patient presented with multiple red follicular papules, confluent, infiltrated erythematous plaques and nodules. Moreover, he was conspicuous for the presence of total alopecia of the scalp and eyebrows. Histopathologically, the lesional skin showed dense follicular and perifollicular infiltrates of atypical lymphocytes. The flow cytometry disclosed the presence of weakly CD4+ CCR4+ cell populations that would not be detected in the peripheral blood from healthy controls. The patient responded well to topical PUVA and systemic etretinate (retinoid-PUVA) and intravenous IFN-gamma. Parallel with the decrease in atypical cells in the peripheral blood, the percentage of weakly CD4+ CCR4+ T cells declined. However, about 1 week after we discontinued this treatment because of the side effects, the lymph node swelling became prominent, and, 4 weeks later, the patient died before restarting any specific chemotherapy.
ChemInform Abstract: A General, Enantioselective Synthesis of 1‐Azabicyclo[m.n.0]alkane Ring Systems. (2013)

Abstract The novel approach to the title compounds, subunits of various natural product classes, involves the highly diastereoselective allylation of sulfimine (II).
ChemInform Abstract: Novel Methods for the Synthesis of 2‐[(4R)‐2‐Oxo‐4‐phenylpyrrolidin‐1‐yl]acetamide ((R)‐Phenotropil). (2013)

Abstract Two novel routes for the synthesis of (R)‐phenotropil (IV) are developed starting from (3R)‐4‐amino‐3‐phenylbutyrate (I).
Methodology for Estimating Safe Charge Limits of Flammable Refrigerants in HVAC&R Applications - Part 1 (2018)

Refrigerant flammability introduces new challenges to the usage of low global warming potential (Low GWP) refrigerants i n real life applications. Those challenges are centered around the deflagration risk associated with their use and its implications on personal safety. Standards have been developed to systematically set maximum allowable flammable refrigerant charges to ensure safety in case of refrigerant leakage. These standards were initially based on limited testing and numerical analyses of refrigerant leakage into confined spaces.
ChemInform Abstract: Synthesis of P‐Stereogenic Phosphoramidite and Phosphorodiamidite Ligands and Their Application in Asymmetric Catalysis. (2016)

Abstract A library of novel P‐stereogenic phosphoramidite and phosphorodiamidite ligands based on chiral Betti bases are synthesized (not shown) and applied to Rh‐catalyzed asymmetric hydrogenation as well as Pd‐catalyzed allylic amination and a Ni‐catalyzed hydrovinylation.
Effects of calcium deficiency on chondrocyte hypertrophy and type X collagen expression in chick embryonic sternum (1993)

Abstract Maintenance of chick embryos in long‐term culture without their calcareous eggshell is a useful method for studying the relationship between calcium homeostasis and cell differentiation during skeletogenesis. Previously, we have shown that in shell‐less (SL) embryos, calcium deficiency induces a cartilage‐like phenotype in osteogenic tissues, such as calvaria (Jacenko and Tuan [1986] Dev. Biol. 115:215). In this investigation, we have studied the relationship between cartilage calcification and hypertrophy, and the expression of type X collagen, a specific product of hypertrophic chondrocytes. For this study, the cephalic (calcifying) and caudal (permanently cartilaginous) regions of sterna from day 18 and day 20 normal (NL) and SL embryos were metabolically labeled with [ 14 C]‐proline. Analysis of the biosynthetic products revealed significant differences in type X collagen expression in the cephalic region of sternal cartilage. In NL tissues, type X collagen production increased from 13.1% of total collagen at day 18 to 43.7% at day 20. In contrast, in SL embryos, type X collagen was not detectable until day 20, when it represented only 1% of total collagen. Comparison of the NL and SL embryos with respect to their serum calcium level and sternal calcium content and histology revealed a direct relationship between low systemic calcium and limited cartilage hypertrophy, undermineralization, and decreased type X collagen production in the sternal cephalic cartilage. Supplementation of CaCO 3 to SL embryos increased their serum and sternal calcium, and restored cartilage hypertrophy, mineralization, and type X collagen synthesis in the cephalic portion of the sterna. These findings confirm that a critical relationship exists between calcium homeostasis, chondrocyte hypertrophy, mineralization, and type X collagen synthesis in the cephalic region of sternal cartilage. These results further demonstrate the importance of calcium in the morphogenetic events of endochondral ossification, in particular the transition from hyaline cartilage to hypertrophic cartilage, and eventually to bone. © 1993 Wiley‐Liss, Inc.
A sphere packing bound on Rayleigh block-fading MIMO channels (2004)

We present a sphere packing bound (SPB) approach to investigate the performance limits of Rayleigh block-fading, multiple antenna systems. Specifically, we derive three sphere packing lower bounds, one tight, one loose, and one approximate, on average word error probability of space-time codes. These bounds provide us with intuition on how system parameters affect the performance limits [M. Fozunbal, S.M. Mclaughlin, and R.W. Schafer, 2002]. It is shown that the performance limits improve significantly for space-time codes that span a larger number of fading blocks. It is shown that the achievable diversity depends not only on the number of antennas and number fading blocks, K, but also on the block length, L, Moreover, it is shown that the block length, L, has a marginal effect on improving the performance limits and it is not possible to achieve arbitrarily small WEP by increasing L.
A global non-invasive methodology for the phenotyping of potato under water deficit conditions using imaging, physiological and molecular tools (2021)

This methodology, when applied to the phenotyping of potato under water deficit conditions, provides a quantitative analysis of leaves and tubers properties at microstructural and molecular levels. The approaches thus developed could therefore be effective in the multi-scale characterization of plant response to water stress, from organ development to gene expression.
N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury (2020)

These results suggest that NAC treatment of skeletal muscle after injury may be a viable option for the prevention of long-term fibrosis and scar formation, facilitating recovery of muscle function.