gebhart/patrepeval huggingface dataset:
A QoS-Oriented Trajectory Optimization in Swarming\n Unmanned-Aerial-Vehicles Communications (2019)

This letter aims to present a novel approach for unmanned aerial vehicles\n(UAV)' path planning with respect to certain quality of service requirements.\nMore specifically, we study the max-min fairness problem in an air-to-ground\ncommunication system where multiple UAVs and multiple ground stations exist. We\njointly optimize the UAVs trajectories and power allocation as well as the user\nscheduling. To this end, we propose an effective iterative algorithm that\nrelies on the successive convex approximation and the block coordinate decent\ntechniques.\n
In Situ, Atomic‐Resolution Observation of Lithiation and Sodiation of WS2 Nanoflakes: Implications for Lithium‐Ion and Sodium‐Ion Batteries (2021)

WS<sub>2</sub> nanoflakes have great potential as electrode materials of lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) because of their unique 2D structure, which facilitates the reversible intercalation and extraction of alkali metal ions. However, a fundamental understanding of the electrochemical lithiation/sodiation dynamics of WS<sub>2</sub> nanoflakes especially at the nanoscale level, remains elusive. Here, by combining battery electrochemical measurements, density functional theory calculations, and in situ transmission electron microscopy, the electrochemical-reaction kinetics and mechanism for both lithiation and sodiation of WS<sub>2</sub> nanoflakes are investigated at the atomic scale. It is found that compared to LIBs, SIBs exhibit a higher reversible sodium (Na) storage capacity and superior cyclability. For sodiation, the volume change due to ion intercalation is smaller than that in lithiation. Also, sodiated WS<sub>2</sub> maintains its layered structure after the intercalation process, and the reduced metal nanoparticles after conversion in sodiation are well-dispersed and aligned forming a pattern similar to the layered structure. Overall, this work shows a direct interconnection between the reaction dynamics of lithiated/sodiated WS<sub>2</sub> nanoflakes and their electrochemical performance, which sheds light on the rational optimization and development of advanced WS<sub>2</sub> -based electrodes.
The Role of a Betaretrovirus in Human Breast Cancer: Enveloping a Conundrum (2022)

Most of the evidence that a human betaretrovirus (HBRV/HMTV) highly related to mouse mammary tumour virus (MMTV) has an etiological role in breast cancer has been summarized in a recent comprehensive Special Issue of "Viruses" entitled "Human Betaretrovirus (HBRV) and Related Diseases". Shortly after publication of this special issue, a detailed analysis of aligned env sequences was published and concluded that (i) MMTV and HBRV/HMTV cannot be distinguished on the basis of aligned env sequences and (ii) more sequence data covering the full-length env or HBRV/HMTV genomes from multiple isolates is needed. Although productive infection of human cells by MMTV (and presumably HBRV/HMTV) has been shown, it is imperative that the receptor(s) enabling HBRV/HMTV to infect human cells are defined. Moreover, there is currently no compelling data for common integration sites, in contrast to MMTV induced mammary tumorigenesis in mice, suggesting that other mechanisms of tumorigenesis are associated with HBRV/HMTV infection. These issues need to be resolved before a clear link between MMTV/HBRV/HMTV and human breast cancer can be concluded.
Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity (2017)

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.
On the resource utilization of multi-connectivity transmission for URLLC services in 5G new radio (2019)

Multi-connectivity with packet duplication, where the same data packet is duplicated and transmitted from multiple transmitters, is proposed in 5G New Radio as a reliability enhancement feature. This paper presents an analytical study of the outage probability enhancement with multi-connectivity, and analyses its cost in terms of resource usage. The performance analysis is further compared against conventional single-connectivity transmission. Our analysis shows that, for transmission with a given block error rate target, multi-connectivity results in more than an order of magnitude outage probability improvement over the baseline single-connectivity scheme. However, such gains are achieved at the cost of almost doubling the amount of radio resources used. Multi-connectivity should thus be selectively used such that its benefits can be harnessed for critical users, while the price to pay in terms of resource utilization is simultaneously minimized.
Tumor cell autocrine motility factor. (1986)

A cell motility-stimulating factor has been isolated, purified, and partially characterized from the serum-free conditioned medium of human A2058 melanoma cells. We term this activity "autocrine motility factor" (AMF). AMF has the properties of a protein with an estimated size of 55 kDa. At concentrations of 10 nM or less, AMF stimulated the random or directed motility of the producer cells. However, AMF is not an attractant for neutrophils. Amino acid analysis of the purified AMF protein revealed a high content of serine, glycine, glutamic acid, and aspartic acid residues. The activity of AMF was not replaced or blocked by known growth factors such as epidermal growth factor or type beta transforming growth factor. Mechanistic studies showed that AMF stimulated the incorporation of [3H]methyl into cell membrane phospholipids after incubation with [methyl-3H]methionine with a sustained increase in the methylation of phosphatidyldimethylethanolamine to phosphatidylcholine. In contrast, AMF did not affect the incorporation of [1,2-14C]choline into phosphatidylcholine. AMF was produced in large amounts by three different clones of ras oncogene-transfected metastatic NIH 3T3 cells but not by the nontransformed parental cells. AMF may play a major role in the local invasive behavior of tumor cells and may also facilitate the concerted invasion by groups of tumor cells.
Higher Order MIMO Antenna Design Using Capacitively Coupled Meandered Loop Element for 5G Smartphone Applications (2023)

In this brief, a compact 10-element multiple-input multiple-output (MIMO) antenna system for fifth generation (5G) wireless communication system is presented. The antenna structure has a T-shaped feeding element and a reduced size capacitively coupled meandered loop radiating element. The proposed MIMO antenna system is operating at 3.5 GHz. The MIMO antenna element is self-isolated and it has a compact size of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$13.45\times6$ </tex-math></inline-formula> mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It exhibits very good isolation of more than 15 dB without using any external decoupling structure like a neutralization line or slot technique. Furthermore, performance parameters like total efficiency are around 40-64%, envelope correlation coefficient (ECC) is below 0.02, while gain of all antennas is between 3-3.4dBi. The performance of the proposed MIMO antenna is also verified through the measurement of its fabricated prototype. In this brief, a compact 10-element multiple-input multiple-output (MIMO) antenna system for fifth generation (5G) wireless communication system is presented.
Increased levels of gangliosides in the plasma and ascitic fluid of patients with advanced ovarian cancer (2004)

Increased serum levels of total gangliosides may reflect shedding or release of gangliosides from the surface of ovarian tumour cells. Secretion of gangliosides may play an important role in the inhibition of anti-tumour immune function commonly observed in advanced ovarian cancer.
Synthetic Studies on Perfluorinated Compounds by Direct Fluorination (2009)

Viewpoint-2 I-1-1.Incunabula 2 I-1-2.Development with material industry 5 I-1-3.Development of fine chemicals 17 I-2.Methodology for Synthesis of Fluorochemicals 24 I-2-1.Methods used in organofluorine industry 24 I-2-2.Direct fluorination with elemental fluorine 27 I-3.Summary of This Thesis 33 I-4.References 38 Chapter II.A New Route to Perfluoro(Propyl Vinyl Ether) Monomer: Synthesis of Perfluoro(2-propoxypropionyl) Fluoride from Non-fluorinated Compounds 47 II-1.Introduction 48 II-2.Results and Discussion 49 II-3.Conclusions 55 II-4.Experimental 56 II-5.References 60 i Chapter III.A New Route to Perfluorinated Vinyl Ether Monomers: Synthesis of Perfluoro(alkoxyalkanoyl) Fluorides from Non-fluorinated Substrates III-1.Introduction III-2.Results and Discussion III-2-1.Synthesis of PPVE precursors III-2-2.Synthesis of perfluoro(alkoxyalkanoyl) fluorides via perfluorinated mixed esters III-3.Conclusions III-4.Experimental III-5.References Chapter IV.Synthesis of Perfluorinated Carboxylic Acid Membrane Monomers by Liquid-phase Direct Fluorination IV-1.Introduction IV-2.Results and Discussion IV-2-1.Preparation of substrates for the PERFECT process IV-2-2.PERFECT process for synthesis of diacyl fluorides IV-2-3.Synthesis of the Flemion monomer by the PERFECT process IV-3.Conclusions IV-4.Experimental ii IV-5.References Chapter V. New Method for Synthesis of Perfluoroalkanesulfonyl Fluorides from Non-fluorinated Substrates V-1.Introduction V-2.Results and discussion V-2-1.Synthesis of FSO 2 CF 2 CF 2 OCF 2 COF (16) V-2-2.Fluorination at and -position of fluorosulfonyl group V-3.Conclusions V-4.Experimental V-5.References Chapter VI.Synthesis of Perfluorinated Ketones by Liquid-Phase Direct Fluorination VI-1.Introduction VI-2.Results and Discussion VI-2-1.PERFECT process for synthesis of hexafluoroacetone VI-2-2.PERFECT process for synthesis of polyfluoroketones for fluoropolymer resists VI-3.Conclusions VI-4.Experimental VI-5.References iii Conclusions List of Publications ArNH 2 ArN 2 X ArN 2 BF 4 ArF + N 2 + BF 3 (4)Another important synthesis of fluoroaromatic compounds, nucleophilic halogen exchange from Cl to F using KF (eq.5), was reported by Gottlieb in 1936. 3, 11 This was the first example of halogen exchange method used in the fluoroarene synthesis.(5) Aromatic compounds with fluorinated side chain was reported by Swarts in 1898 for the first time. 3, 12 Benzotrichloride was found to react rapidly with SbF 3 (eq. 6).PhCCl 3 PhCCl 2 F PhCClF 2 PhCF 3 (6) This conversion from aromatic -CCl 3 to -CF 3 was later achieved with HF and reported in 1930's. 13
Table S5 from RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3 (2023)

&lt;p&gt;Univariate and Multivariate analysis of different prognostic parameters for patients with colorectal cancer in the Beijing cohort 2, n=148&lt;/p&gt;
Post-fertilisation sperm mitophagy: the tale of Mitochondrial Eve and Steve (2017)

Preformationist William Harvey's proclamation of everything live coming from an egg still holds true for mammalian mitochondria and mitochondrial genes. At fertilisation, mitochondria carried into the oocyte cytoplasm by the spermatozoon are sought out and destroyed, leaving only oocyte mitochondria to propagate their mitochondrial (mt) DNA to offspring. This clonal inheritance mode, the 'mitochondrial Eve' paradigm, is mediated by oocytes' resident proteolytic, organelle-targeting mechanisms, including the substrate-specific ubiquitin proteasome system and the autophagic machinery for bulk protein and organelle degradation. Ubiquitination of sperm mitochondria within the cytoplasm of the fertilised oocyte was initially discovered in mammals. More recent studies in Drosophila and Caenorhabditis elegans implicated the ubiquitin-binding autophagy protein sequestosome 1 (SQSTM1) as the early adaptor channelling ubiquitinated sperm mitochondria towards the autophagic machinery. Downstream receptors include microtubule-associated protein 1 light chain 3α (LC3) and GABA type A receptor-associated protein (GABARAP). Among mammals, the domestic pig is the ideal mammalian model of mitochondrial inheritance because of rapid sperm mitophagy at the 1-cell stage of embryo development. Primary recognition of sperm mitochondria by SQSTM1 inside the porcine zygote is followed by GABARAP-containing autophagophore formation, and contributed to by valosin-containing protein (VCP), a 26S proteasome-presenting protein dislocase. Consequently, coinhibition of SQSTM1-GABARAP and VCP activities in the porcine zygotes, resulting in 2- to 4-cell embryos carrying intact sperm mitochondrial sheaths, revived the moniker of 'Mitochondrial Steve'. Further work will identify the determinants of species specificity of sperm mitophagy and explain the interplay and possible consequences of a mismatch between clonal mitochondrial genome and biparentally inherited chromosomal genes encoding for structural mitochondrial proteins and transcription factors. By better understanding sperm mitophagy and its potential failure, we may be able to alleviate mitochondrial disease and early pregnancy loss in livestock and improve their fitness, reproduction and ability to pass favourable production traits to offspring.
Supplementary table from Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;Supplemental table S1 and S2&lt;/p&gt;
The Transcription Factor Sp3 Regulates the Expression of a Metastasis-Related Marker of Sarcoma, Actin Filament-Associated Protein 1-Like 1 (AFAP1L1) (2013)

We previously identified actin filament-associated protein 1-like 1 (AFAP1L1) as a metastasis-predicting marker from the gene-expression profiles of 65 spindle cell sarcomas, and demonstrated the up-regulation of AFAP1L1 expression to be an independent risk factor for distant metastasis in multivariate analyses. Little is known, however, about how the expression of AFAP1L1 is regulated. Luciferase reporter assays showed tandem binding motives of a specificity protein (Sp) located at -85 to -75 relative to the transcriptional start site to be essential to the promoter activity. Overexpression of Sp1 and Sp3 proteins transactivated the proximal AFAP1L1 promoter construct, and electrophoretic mobility shift assays showed that both Sp1 and Sp3 were able to bind to this region in vitro. Chromatin immunoprecipitation experiments, however, revealed that Sp3 is the major factor binding to the proximal promoter region of the AFAP1L1 gene in AFAP1L1- positive cells. Treatment with mithramycin A, an inhibitor of proteins binding to GC-rich regions, prevented Sp3 from binding to the proximal promoter region of AFAP1L1 and decreased its expression in a dose-dependent manner. Finally, knocking down Sp3 using small inhibitory RNA duplex (siRNA) reduced AFAP1L1 expression significantly, which was partially restored by expressing siRNA-resistant Sp3. These findings indicate a novel role for Sp3 in sarcomas as a driver for expression of the metastasis-related gene AFAP1L1.
Synthesis and Photophysics of Dibenz[a,c]phenazine Derivatives (2011)

The synthesis of dipolar dibenz[a,c]phenazine (DBP) derivatives is described. The compounds possess little electronic communication between donor and acceptor units in the ground state regardless of the pattern of substitution. The dipolar derivatives deactivate mostly via electron transfer (eT) under polar conditions. Intersystem crossing is likely to compete for S(1) relaxation.
Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients (2015)

Dendritic cells (DCs) play an important role in the induction of the primary immune response to infection. DCs may express the tryptophan-catabolizing enzyme indolamine2,3-dioxygenase (IDO), which is an inducer of immune tolerance. Because there is evidence that chronic hepatitis C virus (HCV) infection leads to functional impairment of certain DC populations, we analysed IDO expression in DCs and monocytes from chronically infected and recovered HCV patients. The IDO1 and -2 expression was increased significantly in the monocytes of chronic HCV patients but, interestingly, not in those from recovered patients. The myeloid DCs from chronically infected HCV patients also showed enhanced IDO1 expression, while no change in either IDO1 or -2 was found for plasmacytoid DCs. Up-regulation of IDO1 gene expression was confirmed by the presence of enhanced kynurenine/tryptophan ratios in the plasma from chronic HCV patients. Increased IDO1 and -2 expression was also observed in monocytes from healthy donors infected with an adapted mutant of the HCV JFH-1 strain ex vivo, confirming a direct effect of HCV infection. These changes in IDO expression could be prevented by treatment with the IDO inhibitor 1-methyl tryptophan (1-mT). Furthermore, maturation of monocyte-derived DCs from chronically infected HCV patients, as well as well as monocyte-derived DCs infected ex vivo with HCV, was impaired, but this was reversed by 1-mT treatment. This suggests that IDO inhibitors may be used to treat chronic HCV patients in vivo, in conjunction with current therapies, or to activate DCs from patients ex vivo, such that they can be administered back as a DC-based therapeutic vaccine.
Nanomedicine for Gene Delivery and Drug Repurposing in the Treatment of Muscular Dystrophies (2021)

Muscular Dystrophies (MDs) are a group of rare inherited genetic muscular pathologies encompassing a variety of clinical phenotypes, gene mutations and mechanisms of disease. MDs undergo progressive skeletal muscle degeneration causing severe health problems that lead to poor life quality, disability and premature death. There are no available therapies to counteract the causes of these diseases and conventional treatments are administered only to mitigate symptoms. Recent understanding on the pathogenetic mechanisms allowed the development of novel therapeutic strategies based on gene therapy, genome editing CRISPR/Cas9 and drug repurposing approaches. Despite the therapeutic potential of these treatments, once the actives are administered, their instability, susceptibility to degradation and toxicity limit their applications. In this frame, the design of delivery strategies based on nanomedicines holds great promise for MD treatments. This review focuses on nanomedicine approaches able to encapsulate therapeutic agents such as small chemical molecules and oligonucleotides to target the most common MDs such as Duchenne Muscular Dystrophy and the Myotonic Dystrophies. The challenge related to in vitro and in vivo testing of nanosystems in appropriate animal models is also addressed. Finally, the most promising nanomedicine-based strategies are highlighted and a critical view in future developments of nanomedicine for neuromuscular diseases is provided.
RF and THz Identification Using a New Generation of Chipless RFID Tags (2011)

This article presents two chipless RFID approaches where data are reading using electromagnetic waves and where the medium encoding the data is completely passive. The former approach rests on the use of RF waves (more precisely the ultra-wide band UWB). The tags developed for this application are comparable with very specific, planar, conductive, radar targets where the relation between the tag geometry and its electromagnetic signature is perfectly known and is used to encode the data. The principle of operation as well as the realization process of the RF tags presented in this paper is similar to those already reported in the literature. However, contrary to the majority of chipless RFID tags, these labels do not present an antenna function dissociated from the circuit part where the data are stored. Here, functions such as the receiver, the treatment and the emitter of the signal are closely dependent. The data storage capacity of the RF chipless tags is proportional to of the used frequency bandwidth. As radio spectrum is regulated, the number of possible encoding bits is thus strongly limited with this technology. This is the reason why we introduce a new family of tags radically different from the preceding one, where data is encoded in volume thanks to a multilayer structure operating in the THz domain. These two approaches although different are complementary and allow to increase significantly the data storage capacity of the chipless tags. Simulation and experimental results are reported in this paper for both configurations. We demonstrate a coding capacity of 3.3 bit/cm2 for RFID chipless tags and a potential 10 bits coding capacity in the THz domain.
Nanometric Amorphous TiO2 As an Extrinsic Pseudo-Capacitive Electrode for All-Solid-State Asymmetric Hybrid Micro-Supercapacitors: Effects on the Electrochemical Performance (2022)

On-chip solid-state micro-supercapacitors (MSCs) have gained widespread attention owing to their versatile benefits, including high power density and long cycle life 1,2 . Recently asymmetric hybrid microsupercapacitors (AsHMSCs) introducing a charge storage mechanism based on both faradaic reaction and electric double-layer phenomena have been considered to increase the energy density. Within this context, the selection of electrode materials and their interaction at the interface with the electrolyte is a key issue to optimize the AsHMSC electrochemical performance. In this work, nanometric (5-20 nm thick) amorphous TiO 2 films have been elaborated and characterized in liquid and solid-state electrolyte (LiPON) half-cell configurations. Interestingly, TiO 2 films after LiPON deposition exhibited a constant initial amount of intercalated lithium ions for all considered thicknesses and did not require a first activation process, in comparison to the liquid electrolyte configuration. For all considered configurations, the specific capacity extracted from cyclic voltammetry and galvanostatic cycling within [0.5-3V] potential range correspond to the theoretical value expected for the Li x=1 TiO 2 phase at low current density. Furthermore, the cooperative effects of high Li ion intercalation kinetics and Low interfacial charge transfer resistance for 5nm TiO 2 electrode (extracted from electrochemical impedance spectroscopy analysis) exhibit an outstanding specific capacity of 2mC.cm -2 at 1µA.cm -2 , and high rate performance with 60% capacity holding ratio at 100µA.cm -2 , thus highlighting the extrinsic pseudo-capacitive behavior of the sub 10nm electrodes. A TiO 2 5nm/LiPON 100nm/Pt AsHMSC is successfully fabricated, which achieves an operating voltage window of 3V and a specific capacity of 0.3mC.cm -2 at 1mA.cm -2 .In addition, the device also exhibited a 100% coulombic efficiency even after cycling for 6000 continuous charge-discharge cycles. This work offers an approach to tune the Li ion storage properties of TiO 2 by nano-engineering and gives insights into the enhancement of pseudocapacitance-assisted lithium-storage capacity. References Kyeremateng et al., Nature Nanotech 12, 7–15 (2017). https://doi.org/10.1038/nnano.2016.196 Sallaz et al., J. Power Sources 451, 227786 (2020), doi: 10.1016/j.jpowsour.2020.227786. Figure 1