gebhart/patrepeval huggingface dataset:
Automatic construction of unique signatures and confusable sets for natural language directory assistance applications (2003)

This paper addresses the problem of building natural language based grammars and language models for directory assistance applications that use automatic speech recognition. As input, one is given an electronic version of a standard phone book, and the output is a grammar or language model that will accept all the ways in which one might ask for a particular listing. We focus primarily on the problem of processing listings for businesses and government offices, but our techniques can be used to speech-enable other kinds of large listings (like book titles, catalog entries, etc.). We have applied these techniques to the business listings of a state in the Midwestern United States, and we present highly encouraging recognition results.
Monolithic Integration of Quantum Cascade Laser, Quantum Cascade Detector and Slotted Photonic Crystal Waveguide for Absorbance Sensing from λ=3–15μm (2018)

We demonstrate monolithic integration of quantum cascade laser and detector and slotted photonic crystal waveguide on a single epitaxial heterostructure for on-chip slow light enhanced absorption sensing. Designs can cover λ=3-15μm wavelengths without wafer bonding.
General Approach for the Synthesis of Sarpagine/Ajmaline Indole Alkaloids. Stereospecific Total Synthesis of the Sarpagine Alkaloid (+)-Vellosimine (2000)

[reaction: see text] (+)-Vellosimine has been synthesized enantiospecifically in 27% overall yield from commercially available D-(+)-tryptophan methyl ester via the asymmetric Pictet-Spengler reaction and a stereocontrolled intramolecular palladium-coupling reaction as key steps.
Artificial Diversity and Defense Security (ADDSec) Final Report (2018)

Critical infrastructure systems continue to foster predictable communication patterns and static configurations over extended periods of time. The static nature of these systems eases the process of gathering reconnaissance information that can be used to design, develop, and launch attacks by adversaries. In this research effort, the early phases of an attack vector will be disrupted by randomizing application port numbers, IP addresses, and communication paths dynamically through the use of overlay networks within Industrial Control Systems (ICS). These protective measures convert static systems into "moving targets," adding an additional layer of defense. Additionally, we have developed a framework that automatically detects and defends against threats within these systems using an ensemble of machine learning algorithms that classify and categorize abnormal behavior. Our proof-of-concept has been demonstrated within a representative ICS environment. Performance metrics of our proof-of-concept have been captured with latency impacts of less than a millisecond, on average.
Extraction of Trap States at the Oxide-Silicon Interface and Grain Boundary in Polycrystalline Silicon Thin-Film Transistors (2001)

A technique to extract trap states at the oxide-silicon interface and grain boundary has been developed for polycrystalline silicon thin-film transistors with large grains. From the capacitance–voltage characteristic, the interface traps can be extracted. The potential and carrier density are also extracted. From the potential, carrier density and current–voltage characteristic, the boundary traps can be extracted by considering the potential barrier at the grain boundary. Using a two-dimensional device simulation, the adequacy of this extraction technique was confirmed.
COX-2 inhibitors and cardiovascular risk (2006)

Summary Even though non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used for a long time, the search continues for anti-inflammatory drugs with few side-effects. COX-2 inhibitors are currently most debated, because they have less gastrointestinal side effects but have been linked to increased cardiovascular morbidity and mortality, presumably related to thrombotic events. This has brought about the withdrawal of rofecoxib and other COX-2 inhibitors from the market. Although the results of several large studies with prospective, randomized design and meta-analysis of different trials have led to the demise of many popular COX-2 inhibitors, yet the conclusion seems to be rather simplistic. This review presents evidence from basic biology and clinical studies with the expectation that a balanced position, particularly in relation to increase in cardiovascular events, may be elucidated.
Multiple sgRNAs for one-step inactivation of the duplicatedacetyl-coenzyme A carboxylase 2(ACC2) genes inBrassica napus (2022)

Efficient plastid transformation in Arabidopsis (Arabidopsis thaliana) requires genetic lines that are hypersensitive to spectinomycin due to the absence of a chloroplast acetyl-coenzyme A carboxylase (ACCase) encoded in the acetyl-coenzyme A carboxylase 2 (ACC2) nuclear gene. To obtain plastid transformation-competent oilseed rape (Brassica napus), we inactivated all nuclear encoded, chloroplast targeted ACCase copies using CRISPR-Cas9. Brassica napus (2n = 38, AACC) is a recent interspecific hybrid of Brassica rapa (2n = 20, AA) and B. oleracea (2n = 18, CC) and is expected to have at least two ACC2 copies, one from each parent. The sequenced genome has two ACC2 copies, one that is B. rapa-like and one that is B. oleracea-like. We designed single-guide RNAs (sgRNAs) that could simultaneously inactivate both nuclear ACC2 copies. We expressed Cas9 from a chimeric egg cell promoter 1.2 (EC1.2p) known to yield homozygous or biallelic mutants in Arabidopsis in the T1 generation. To maximize the probability of functionally inactivating both orthologs in a single step, each of the two vectors carried four sgRNAs. Four T0 transgenic lines were obtained by Agrobacterium tumefaciens-mediated hypocotyl transformation. Amplicon sequencing confirmed mutations in ACC2 genes in 10 T1 progeny, in seven of which no wild-type (WT) copy remained. The B. napus T2 seedlings lacking WT ACC2 gene copies exhibited a spectinomycin hypersensitive phenotype, suggesting that they will be a useful resource for chloroplast genome transformation.
A solder self-assembled large angular displacement torsional electrostatic micromirror (2003)

Solder self-assembled micromirrors have the advantages of rigid electrical and structural connections to the substrate as well as compact assembly mechanisms. In addition solder assembly allows a structure to be rotated to any angle desired. In this work, these advantages are used to produce a novel electrostatic micromirror that can stably rotate /spl plusmn/10/spl deg/ from its assembled position. The compact solder mechanism allows each of three mirror components to be assembled independently to individual angles. After assembly the design is statically tested and compared to both analytical and finite element (FE) model results.
Table S5 from Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers (2023)

&lt;p&gt;HLA genotypes information for samples with TSSK2 expression.&lt;/p&gt;
Beyond step counts: Including wear time in prosthesis use assessment for lower-limb amputation (2023)

Capturing don time and temporary doffs and distinguishing weight shifts from walks may provide insight relevant to patient care. Longer-term monitoring studies should be conducted, and the clinical utility of the data evaluated.
Liquid metal droplets for RF MEMS switches (2006)

This paper discusses the design, fabrication and characterization of microstructures for the manipulation of very small liquid-metal droplets. In particular we demonstrate the successful actuation of 50-/spl mu/m liquid-metal droplets with an actuation voltage of less than 70V. Liquid contacts have the potential of increased power handling, which renders these structures good candidates for reliable high-power MEMS switches.
The Spectrum of βig-h3 Gene Mutations in Japanese Patients with Corneal Dystrophy (2000)

Depending on the specific mutation in the beta ig-h3 gene, the phenotypes of corneal dystrophy may differ. Our results indicate that assay of mutations in the beta ig-h3 gene is required to establish a correct diagnosis.
Sphere (2008)

Sphere is a multi-user, multi-touch-sensitive spherical display in which an infrared camera used for touch sensing shares the same optical path with the projector used for the display. This novel configuration permits: (1) the enclosure of both the projection and the sensing mechanism in the base of the device, and (2) easy 360-degree access for multiple users, with a high degree of interactivity without shadowing or occlusion. In addition to the hardware and software solution, we present a set of multi-touch interaction techniques and interface concepts that facilitate collaborative interactions around Sphere. We designed four spherical application concepts and report on several important observations of collaborative activity from our initial Sphere installation in three high-traffic locations.
A prospective cohort study of practice guidelines in inflammatory bowel disease (2001)

Practice guidelines should improve care, but they are not routinely followed, in part because of lack of proven benefit. We evaluated the effect of introducing guidelines for inflammatory bowel disease (IBD) on practice variation and the IBD Quality of Life (IBDQ) score.This was a prospective, controlled, cohort study. A total of 65 patients were matched according to month of visit, diagnosis, and disease activity with control subjects seen 1 yr earlier. Physicians were educated throughout the study regarding the guidelines. Variation was measured by the Mayo Practice Guideline Score (MPGS), a 15-point assessment of documentation of diagnosis, nutrition, social support, education, functional status, and treatment. The IBDQ was measured at baseline and at 1 yr in the intervention group and after 1 yr in the control group.The MPGS was significantly higher in the intervention group compared to the controls (p = 0.002), with median values of 12 versus 11. The IBDQ median score increased significantly in the intervention group (p < 0.001), baseline median of 133 versus 15-month median of 184. However, the final IBDQ was not significantly higher in the intervention group than in the controls (p = 0.33).Practice guidelines for IBD reduce practice variation. The quality of life improved significantly compared to baseline with practice guidelines, but not compared to controls, perhaps because of the small sample size and homogenous practice setting. The MPGS is a tool that can be used in day-to-day management of IBD patients.
Total Synthesis of (.+-.)-Atpenin B. An Original "Clockwise" Functionalization of 2-Chloropyridine (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of (.+-.)-Atpenin B. An Original "Clockwise" Functionalization of 2-ChloropyridineFrancois Trecourt, Marc Mallet, Olivier Mongin, and Guy QueguinerCite this: J. Org. Chem. 1994, 59, 21, 6173–6178Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jo00100a017https://doi.org/10.1021/jo00100a017research-articleACS PublicationsRequest reuse permissionsArticle Views932Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cellular uptake of polylactide particles induces size dependent cytoskeletal remodeling in antigen presenting cells (2021)

Phagocytosis of particulate vaccine delivery systems is a critical immune mechanism involved in antigen capture and processing by macrophages and dendritic cells. The internalization and degradation of the particles involve a complex sequence of events. This process coordinates lipids, signaling proteins, and the cytoskeleton. Dynamic changes in the actin cytoskeleton are essential for phagocytosis and antigen presentation. Knowledge regarding the correlation of surface properties, attached ligand density and geometric size of particles with the efficiency of phagocytosis may facilitate their design and application. To investigate this, polylactide biodegradable particles with different diameters (2-4 μm and 200-300 nm) were exposed to murine macrophages and dendritic cells and the effect of size on a series of cellular responses was evaluated. Cellular uptake studies using microscopy and flow cytometry showed size dependent internalization of particles, with nanoparticles accumulating in cells at a faster rate. The particles induced homoaggregation of cells and also showed cytoskeletal remodeling that could be inhibited by cytochalasin-D. Scanning electron microscopy images showed the time dependent formation of phagocytic cups and invaginations that promote particle uptake. The particles were observed to co-localized with the endo-lysosomal compartments after phagocyotosis. In our experiments, particle mediated immunoactivation, antigen processing and cytokine secretion have shown a good correlation with the uptake process. These findings would allow a better understanding of the process of particle uptake and may be instrumental in the rational design of optimal vaccine delivery systems.
Gossip and Distributed Kalman Filtering: Weak Consensus Under Weak Detectability (2010)

The paper presents the gossip interactive Kalman filter (GIKF) for distributed Kalman filtering for networked systems and sensor networks, where intersensor communication and observations occur at the same time-scale. The communication among sensors is random; each sensor occasionally exchanges its filtering state information with a neighbor depending on the availability of the appropriate network link. We show that under a weak distributed detectability condition: 1) the GIKF error process remains stochastically bounded, irrespective of the instability of the random process dynamics; and 2) the network achieves weak consensus, i.e., the conditional estimation error covariance at a (uniformly) randomly selected sensor converges in distribution to a unique invariant measure on the space of positive semidefinite matrices (independent of the initial state). To prove these results, we interpret the filtering states (estimates and error covariances) at each node in the GIKF as stochastic particles with local interactions. We analyze the asymptotic properties of the error process by studying as a random dynamical system the associated switched (random) Riccati equation, the switching being dictated by a nonstationary Markov chain on the network graph.
Evolution of sputtered tungsten coatings at high temperature (2013)

Sputtered tungsten (W) coatings were investigated as potential high temperature nanophotonic material to replace bulk refractory metal substrates. Of particular interest are materials and coatings for thermophotovoltaic high-temperature energy conversion applications. For such applications, high reflectance of the substrate in the infrared wavelength range is critical in order to reduce losses due to waste heat. Therefore, the reflectance of the sputtered W coatings was characterized and compared at different temperatures. In addition, the microstructural evolution of sputtered W coatings (1 and 5 μm thick) was investigated as a function of anneal temperature from room temperature to 1000 °C. Using in situ x-ray diffraction analysis, the microstrain in the two samples was quantified, ranging from 0.33% to 0.18% for the 1 μm sample and 0.26% to 0.20% for the 5 μm sample, decreasing as the temperature increased. The grain growth could not be as clearly quantified due to the dominating presence of microstrain in both samples but was in the order of 20 to 80 nm for the 1 μm sample and 50 to 100 nm for the 5 μm sample, as deposited. Finally, the 5 μm thick layer was found to be rougher than the 1 μm thick layer, with a lower reflectance at all wavelengths. However, after annealing the 5 μm sample at 900 °C for 1 h, its reflectance exceeded that of the 1 μm sample and approached that of bulk W found in literature. Overall, the results of this study suggest that thick coatings are a promising alternative to bulk substrates as a low cost, easily integrated platform for nanostructured devices for high-temperature applications, if the problem of delamination at high temperature can be overcome.
New Two-Photon Absorbing Squaraine Derivative with Efficient Near-Infrared Fluorescence, Superluminescence, and High Photostability (2022)

The nature of linear photophysical and nonlinear optical properties of a new squaraine derivative 2,4-bis[4-(azetidyl)-2-hydroxyphenyl]squaraine (<b>1</b>) with efficient near-infrared (NIR) emission was comprehensively analyzed based on spectroscopic, photochemical, and two-photon absorption (2PA) measurements, along with quantum chemical analysis. The steady-state absorption, fluorescence, and excitation anisotropy spectra of <b>1</b> and its fluorescence emission lifetimes revealed the multiple aspects of the electronic structure of <b>1</b>, including the relative orientations of the main transition dipoles, effective rotational volumes in solvents of different polarities, and a maximum molar extinction of 1.35 × 10<sup>-5</sup> M<sup>-1</sup>·cm<sup>-1</sup>, which is unusually small for similar symmetric squaraines. The degenerate 2PA spectrum of <b>1</b> was obtained over a broad spectral range under femtosecond excitation, using standard open-aperture Z-scan and two-photon induced fluorescence methods, revealing maximum 2PA cross sections of ∼400 GM. Squaraine <b>1</b> exhibited efficient superluminescence emission in the polar solvent (dichloromethane) at room temperature under femtosecond pumping conditions. Quantum chemical analysis of the electronic structure of <b>1</b> was performed using the DFT/TD-DFT level of theory and found to be in good agreement with experimental data. The new squaraine derivative <b>1</b> displayed high fluorescence quantum yield, efficient NIR superluminescence, large 2PA cross sections, and high photostability with a photodecomposition quantum yield ∼4 × 10<sup>-6</sup>, suggesting its potential for applications in two-photon fluorescent bioimaging and lasing.
Real-time Spatio-Temporal Action Localization in 360 Videos (2020)

Spatio-temporal action localization of human actions in a video has been a popular topic over the past few years. It tries to localize the bounding boxes, the time span and the class of one action, which summarizes information in the video and helps humans understand it. Though many approaches have been proposed to solve this problem, these efforts have only focused on perspective videos. Unfortunately, perspective videos only cover a small field-of-view (FOV), which limits the capability of action localization. In this paper, we develop a comprehensive approach to real-time spatio-temporal localization that can be used to detect actions in 360 videos. We create two datasets named UCF-101-24-360 and JHMDB-21-360 for our evaluation. Our experiments show that our method consistently outperforms other competing approaches and achieves a real-time processing speed of 15fps for 360 videos.
712 SBT6290, a systemically administered Nectin-4-directed TLR8 ImmunoTAC (TM) therapeutic, is a potent human myeloid cell agonist for the treatment of Nectin-4-expressing tumors (2020)

<h3>Background</h3> SBT6290 is a novel therapeutic comprised of a selective TLR8 agonist conjugated to a Nectin-4-specific monoclonal antibody, designed for systemic delivery and tumor-localized activation of myeloid cells. Nectin-4 is a cell surface adhesion molecule that is overexpressed in multiple solid tumor types including triple negative breast, head and neck, lung, and urothelial cancers, with limited expression in normal tissues. Many solid tumors, including those expressing Nectin-4, are resistant to immunotherapy due to immune-suppressive mechanisms, loss of HLA, low neoantigen availability, and/or minimal T cell infiltrates. These tumors, however, are often replete with myeloid cells. Activation of these cells has emerged as a promising approach in overcoming resistance mechanisms to current cancer immunotherapies. TLR8 is highly expressed in myeloid cell types prevalent in human tumors, including conventional DCs and macrophages. Agonism of TLR8 in human myeloid cells activates a broad spectrum of anti-tumor immune mechanisms, including proinflammatory cytokine production, repolarization of suppressive myeloid cells, and the priming of CTL responses. Here, we show that SBT6290 potently activates human myeloid cells in a Nectin-4-dependent manner and that a mouse surrogate confers single agent anti-tumor activity in preclinical studies. These data support the development of SBT6290 for the treatment of patients with Nectin-4-expressing tumors. <h3>Methods</h3> SBT6290 activity was characterized in vitro using co-culture systems consisting of human immune cells and Nectin-4-expressing tumor cells. The in vivo efficacy of the SBT6290 surrogate was evaluated as a single agent in mouse tumor models expressing Nectin-4. <h3>Results</h3> Studies with human immune cells show that SBT6290 potently induces multiple anti-tumor immune activities including proinflammatory cytokine and chemokine production, inflammasome activation, direct activation of DCs and indirect T and NK cell cytolytic activity. This activity requires the presence of Nectin-4 expressing tumor cells and the engagement of Fc gamma receptors on the surface of the myeloid cells by the conjugate to facilitate delivery of SBT6290 into myeloid cells. Notably, SBT6290 is &gt;100 fold more potent than the free, unconjugated TLR8 agonist. Systemic administration of a SBT6290 surrogate in mice results in robust single agent efficacy in tumor models intrinsically resistant to checkpoint blockade, including the EMT6 model engineered to express human Nectin-4. <h3>Conclusions</h3> The preclinical data described here show the potential for SBT6290 to drive robust, single agent anti-tumor responses and support the clinical development of SBT6290 for patients with Nectin-4 expressing tumors.