gebhart/patrepeval huggingface dataset:
FACTORS ASSOCIATED WITH HYPERTENSION PREVALENCE AND CONTROL AMONG LEBANESE TYPE 2 DIABETIC PATIENTS (2016)

&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The objectives of this study were to assess the prevalence of hypertension and the level of blood pressure (BP) control among a cohort of diabetic Lebanese patients on antihypertensive medications, as well as to identify factors associated with hypertension prevalence and uncontrolled BP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional retrospective study was conducted in a tertiary health care clinic that is specialized in the management and follow-up of diabetic outpatients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among the&lt;strong&gt; &lt;/strong&gt;700 type 2 diabetes mellitus patient files that were screened529 (75%) were found to have hypertension. Hypertension was more prevalent in women, patients aged ≥65-year-old, and those having a body mass index (BMI) of ≥30 (kg/m&lt;sup&gt;2&lt;/sup&gt;) (p-value&amp;lt;0.05). Among the hypertensive cohort, 465 T2DM were on antihypertensive medications and were included in the hypertension control analysis. Ninety-three patients (20%) attained BP control (SBP&amp;lt;140 and DBP&amp;lt;90 mmHg). Multivariate analyses revealed three factors that were significantly associated with uncontrolled BP control: Age being ≥65 y (adjusted OR = 1.96 (95% CI: 1.07–3.61, p-value&amp;lt;0.05), male gender (adjusted OR = 2.57, 95% CI: 1.41–4.66, p-value&amp;lt;0.05) and uncontrolled HDL (adjusted OR = 1.58, 95% CI: 1.33–2.01, p-value = 0.05). &lt;em&gt;&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;:&lt;strong&gt; &lt;/strong&gt;Hypertension is prevalent among the study patients. However, attainment of BP control was poor among these patients. Therefore, there is a need for studies that determine reasons behind this low BP control rate in order to design interventions aiming at improving the standard of care for these patients.&lt;/p&gt;
Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties (2018)

Free fatty acid receptor 2 (FFA2/GPR43) is a receptor for short-chain fatty acids reported to be involved in regulation of metabolism, appetite, fat accumulation, and inflammatory responses and is a potential target for treatment of various inflammatory and metabolic diseases. By bioisosteric replacement of the central pyrrolidine core of a previously disclosed FFA2 agonist with a synthetically more tractable thiazolidine, we were able to rapidly synthesize and screen analogues modified at both the 2- and 3-positions on the thiazolidine core. Herein, we report SAR exploration of thiazolidine FFA2 agonists and the identification of 31 (TUG-1375), a compound with significantly increased potency (7-fold in a cAMP assay) and reduced lipophilicity (50-fold reduced clog P) relative to the pyrrolidine lead structure. The compound has high solubility, high chemical, microsomal, and hepatocyte stability, and favorable pharmacokinetic properties and was confirmed to induce human neutrophil mobilization and to inhibit lipolysis in murine adipocytes.
X-ray microscopy study of chromonic liquid crystal dry film texture (2007)

Soft x-ray spectromicroscopy has been used to investigate the degree of the molecular alignment of sulfonated benzo[de]benzo[4.5]imidazo[2,1-a]isoquinoline[7,1], a lyotropic chromonic liquid crystal (LCLC). LCLC thin films cast from concentrated aqua solution (20%wt.) , aligned by shear flow and dried, show strong linear dichroism in their C-, N-, O-, S- K edge near edge x-ray spectra (NEXAFS). The carbon K edge has been used for quantitative evaluation of the orientational texture of the films at a submicron spatial scale. This has verified there is predominantly in-plane alignment of the LC director. To highlight the role of hydrophobic-hydrophilic interactions, two stereoisomers of the same dye has been synthesized with different positioning of terminal sulfonate groups, in the form of a mixture of isomers with sulfonate groups in 2,10 and 2,11 positions (Y104 compound) and in a 5,10-disulfo arrangement (Y105). Both compounds develop characteristic herringbone-type texture with similar domain sizes. Polarized optical microscopy and higher resolution x-ray microscopy show sinusoidal-like undulations of the molecular director, with occasional crisscross appearance. Such behavior is found to be consistent with earlier observation of striations, characteristic of the columnar phase. The drastic difference in the degree of undulation ( +/-15 degrees in Y104 and +/-7 degrees in Y105 films) and long period of undulation (approaching the film thickness) requires further analysis. It was also found that the degree of in-plane order within domains changes from 0.8 for Y104 to >0.9 in Y105 films.
Abstract 963: IDH2(R140Q) knock-in mouse recapitulating human type II D-2-hydroxyglutaric aciduria (2014)

Abstract A single amino acid substitution, R140Q, in isocitrate dehydrogenase 2 (IDH2) confers a novel enzymatic activity that converts α-ketoglutarate (αKG) to D-2-hydroxyglutarate (D-2-HG). This gain-of-function mutation has been identified in patients with type II D-2-hydroxyglutaric aciduria (D-2-HGA), a rare and severe neurometabolic disorder that presents with a range of clinical findings, including seizures, hypotonia, developmental delay, cardiomyopathy, dysmorphic features and early death. There are no effective therapies for this inherited autosomal dominant disease. Here, we report the generation and characterization of a mouse genetic model that recapitulates key features of type II D-2-HGA. A single amino acid replacement, R140Q, was introduced via homologous recombination into the endogenous mouse IDH2 gene locus, to create heterozygous IDH2(R140Q) knock-in (KI) mice. These KI mice produce significantly elevated levels of D-2-HG in all tissues tested, and exhibit multiple defects consistent with symptoms from D-2-HGA patients, including early mortality, brain lesions, and cardiac hypertrophy. Echocardiogram reveals impaired systolic function with a diffusely hypokinetic left ventricle and low ejection fraction. The IDH2(R140Q) knock-in mouse model provides a valuable tool to elucidate the underlying disease mechanism of D-2-HGA and to evaluate ways to mitigate the disease. Citation Format: Fang Wang, Jeremy Travins, Zhizhong Lin, Lee Silverman, Yue Chen, Yuxuan Lu, Hua Yang, Michael Su, Yong Cang, Kate Ellwood-Yen, Shengfang Jin. IDH2(R140Q) knock-in mouse recapitulating human type II D-2-hydroxyglutaric aciduria. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 963. doi:10.1158/1538-7445.AM2014-963
The use of optically coherent detection techniques for true-time delay phased array and systems (1995)

We analyze a true-time-delay, optically controlled phased array antenna system whereby beam forming is accomplished using a large number of antenna elements that can receive any of several different microwave true-time-delays via the use of coherent optical carriers transmitted through a single fiber. The transmitter and receiver architectures are described in detail. We present calculations for the signal-to-noise ratio (SNR), the signal-to-interchannel interference ratio (SIR) and dynamic range (DR) of one channel for various modulation-demodulation schemes (i.e., AM-heterodyne, FM, PM). We show for an example system that can accommodate 128 antenna elements and provide 128 different delays (7 bits), assuming AM modulation with a bandwidth of 1 MHz, a transmitter power of -5 dBm and a laser linewidth of 10 MHz, we can obtain DR/spl sime/50 dB for one channel using a channel separation twelve times of that of the microwave frequency (f/sub m/). For the FM scheme, DR/spl sime/60 dB can be obtained for one channel with a laser linewidth of 1 MHz, a FM modulation index of one, and a channel spacing of about 13f/sub m/. With a local oscillator laser tuning range of 100 /spl Aring/, the system can provide seven-bit resolution for a 128 element antenna array. It is found that coherent optically controlled phased array antennas provide improved controllability over direct detection method, and can have the SNR, SIR and DR that meet the stringent requirements of modern high resolution microwave antenna systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -]. (2014)

Hypertension, osteoporosis and vascular calcification are major diseases in the recent aging society and may share the same backgrounds genetically and environmentally. As treatments to prevent aging-related diseases simultaneously are desirable, we investigate common backgrounds underling these diseases. Renin- angiotensin system, which causes high blood pressure, is found to be involved in bone metabolism. Angiotensin II has been shown to accelerate osteoporosis through RANKL up-regulation in osteoblast. RANKL, in turn, contributes to vascular calcification by regulating bone morphogenetic protein-2 and MGP expression, as well as bone-related proteins. Angiotensin type 1 receptor blockers (ARBs) ameliorate osteoporosis and vascular calcification beyond their blood pressure lowering effects. These pleiotropic effects of antihypertensive drugs such as ARBs might benefit especially hypertensive postmenopausal women.
Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer (2017)

Mammalian genomes are replete with interspersed repeats reflecting the activity of transposable elements. These mobile DNAs are self-propagating, and their continued transposition is a source of both heritable structural variation as well as somatic mutation in human genomes. Tailored approaches to map these sequences are useful to identify insertion alleles. Here, we describe in detail a strategy to amplify and sequence long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in the human genome, transposon insertion profiling by next-generation sequencing (TIPseq). We also report the development of a machine-learning-based computational pipeline, TIPseqHunter, to identify insertion sites with high precision and reliability. We demonstrate the utility of this approach to detect somatic retrotransposition events in high-grade ovarian serous carcinoma.
Targeting proteins to the cell wall of sporulating Bacillus anthracis (2006)

Dormant spores of Bacillus anthracis germinate during host infection and their vegetative growth and dissemination precipitate anthrax disease. Upon host death, bacilli engage a developmental programme to generate infectious spores within carcasses. Hallmark of sporulation in Bacillus spp. is the formation of an asymmetric division septum between mother cell and forespore compartments. We show here that sortase C (SrtC) cleaves the LPNTA sorting signal of BasH and BasI, thereby targeting both polypeptides to the cell wall of sporulating bacilli. Sortase substrates are initially produced in different cell compartments and at different developmental stages but penultimately decorate the envelope of the maturing spore. srtC mutants appear to display no defect during the initial stages of infection and precipitate lethal anthrax disease in guinea pigs at a similar rate as wild-type B. anthracis strain Ames. Unlike wild-type bacilli, srtC mutants do not readily form spores in guinea pig tissue or sheep blood unless their vegetative forms are exposed to air.
Two-Dimensional Strongly Coupled Plasma on a Liquid Surface (2002)

A simple system of a two‐dimensional (2D) strongly coupled plasma has been developed by using charged fine particles in an oil suspension. The fine silica (SiO2) particles placed on the bottom of a concave electrode where silicon oil is filled are charged up by applying a voltage with respect to the upper glass electrode, which is coated by electro‐conductive film (ITO). The particles are confined on the oil surface by the surface tension and the electric field between the electrodes. The long time evolution of Coulomb crystal growth was observed.
Does metaphor increase visual language usability? (1999)

Previous research suggests that the graphical metaphor should increase the usability of visual programming languages (VPLs) by providing an instructional aid when learning to use the language. This paper describes three experiments which manipulated the degree of metaphor in VPLs. In the first, an implicit pictorial metaphor was added to a data flow language, while in the second and third an explicit explanatory metaphor was provided for diagrams showing computational concepts. In both cases, the performance of novices was compared to that of expert programmers, in order to judge the improvement in usability that might result from this instructional device. The resulting benefits of metaphor were smaller than expected especially relative to the advantage of experience. This suggests that metaphor may not be an essential component in the usability of VPLs.
Finite Element Modeling of CNS White Matter Kinematics: Use of a 3D RVE to Determine Material Properties (2013)

Axonal injury represents a critical target area for the prevention and treatment of traumatic brain and spinal cord injuries. Finite element (FE) models of the head and/or brain are often used to predict brain injury caused by external mechanical loadings, such as explosive waves and direct impact. The accuracy of these numerical models depends on correctly determining the material properties and on the precise depiction of the tissues' microstructure (microscopic level). Moreover, since the axonal microstructure for specific regions of the brain white matter is locally oriented, the stress, and strain fields are highly anisotropic and axon orientation dependent. Additionally, mechanical strain has been identified as the proximal cause of axonal injury, which further demonstrates the importance of this multi-scale relationship. In this study, our previously developed FE and kinematic axonal models are coupled and applied to a pseudo 3-dimensional representative volume element of central nervous system white matter to investigate the multi-scale mechanical behavior. An inverse FE procedure was developed to identify material parameters of spinal cord white matter by combining the results of uniaxial testing with FE modeling. A satisfactory balance between simulation and experiment was achieved via optimization by minimizing the squared error between the simulated and experimental force-stretch curve. The combination of experimental testing and FE analysis provides a useful analysis tool for soft biological tissues in general, and specifically enables evaluations of the axonal response to tissue-level loading and subsequent predictions of axonal damage.
A mouse tissue atlas of small noncoding RNA (2020)

Small noncoding RNAs (ncRNAs) play a vital role in a broad range of biological processes both in health and disease. A comprehensive quantitative reference of small ncRNA expression would significantly advance our understanding of ncRNA roles in shaping tissue functions. Here, we systematically profiled the levels of five ncRNA classes (microRNA [miRNA], small nucleolar RNA [snoRNA], small nuclear RNA [snRNA], small Cajal body-specific RNA [scaRNA], and transfer RNA [tRNA] fragments) across 11 mouse tissues by deep sequencing. Using 14 biological replicates spanning both sexes, we identified that ∼30% of small ncRNAs are distributed across the body in a tissue-specific manner with some also being sexually dimorphic. We found that some miRNAs are subject to "arm switching" between healthy tissues and that tRNA fragments are retained within tissues in both a gene- and a tissue-specific manner. Out of 11 profiled tissues, we confirmed that brain contains the largest number of unique small ncRNA transcripts, some of which were previously annotated while others are identified in this study. Furthermore, by combining these findings with single-cell chromatin accessibility (scATAC-seq) data, we were able to connect identified brain-specific ncRNAs with their cell types of origin. These results yield the most comprehensive characterization of specific and ubiquitous small RNAs in individual murine tissues to date, and we expect that these data will be a resource for the further identification of ncRNAs involved in tissue function in health and dysfunction in disease.
Correlation between mean and minimum joint space measurements in a long-term trial with glucosamine sulfate, an osteoarthritis modifying agent (2002)

peer reviewed
High-Q Etchless Silicon Ring Resonator (2010)

We demonstrate high-Q silicon ring resonators fabricated by selective oxidation without any silicon etching. We achieve an intrinsic quality factor of 480,000 in 50 µm radii rings with ring losses of 0.9 dB/cm.
Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure (2006)

Our study is the first to show that copeptin is an excellent predictor of outcome in advanced heart failure patients. Its value is superior to that of BNP in predicting death and a combined endpoint, although BNP is still suitable for predicting chronic heart failure (CHF) re-hospitalization. Our data imply that vasopressin antagonism might be a new target to improve outcome in this population.
Room‐Temperature InGaAs Nanowire Array Band‐Edge Lasers on Patterned Silicon‐on‐Insulator Platforms (Phys. Status Solidi RRL 3/2019) (2019)

The back-cover image represents lasing from square-lattice nanowire array photonic crystals on silicon-on-insulator (SOI) platforms. Integration of light sources on silicon platforms is regarded as a crucial requirement for various nanophotonic applications, but the lattice mismatch between III–V materials and silicon has been one of the major challenges to realize this. Here, Hyunseok Kim et al. (article no. 1800489) employed bottom-up integrated nanowires to overcome this issue and realize highquality III.V materials on silicon. InGaAs/InP core/shell nanowires form photonic crystals with a footprint of only 3.0×3.0 μm2, and a high Q factor of 23,000 is achieved by integrating these nanowires on two-dimensional silicon gratings. Roomtemperature lasing is observed from a fundamental band-edge mode at 1290 nm, which is the O-band of the telecommunication wavelength. These results represent a meaningful step toward ultracompact and monolithic III–V lasers on silicon photonic platforms.
Bacterial metapopulations in nanofabricated (2006)

We have constructed a linear array of coupled, microscale patchesof habitat. When bacteria are inoculated into this habitat land-scape, a metapopulation emerges. Local bacterial populations ineach patch coexist and weakly couple with neighbor populationsinnearbypatches.Thesespatiallydistributedbacterialpopulationsinteract through local extinction and colonization processes. Wehave further built heterogeneous habitat landscapes to study theadaptivedynamicsofthebacterialmetapopulations.Bypatterninghabitat differences across the landscape, our device physicallyimplementsanadaptivelandscape.Inlandscapeswithhighernichediversity, we observe rapid adaptation to large-scale, low-quality(high-stress) areas. Our results illustrate the potential lying at theinterface between nanoscale biophysics and landscape evolution-ary ecology.
Enhanced outcoupling from organic light-emitting diodes using aperiodic dielectric mirrors (2007)

Aperiodic dielectric stacks between the substrate and transparent anode in organic light-emitting diodes are used to improve the optical outcoupling efficiency. The authors demonstrate that a nine-layer SiO2∕SiNx aperiodic dielectric stack improves the brightness by 80% within a 60° viewing cone for a red-emitting organic light-emitting diode, while maintaining a Lambertian emission pattern. As the refractive index contrast between the two materials used in a two-component multilayer dielectric stack is increased, a brightness improvement of 170% in a 60° viewing cone is achievable while maintaining a Lambertian emission profile.
The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis The GenBank accession number for the sequence reported in this paper is U65788. (1999)

Neisseria meningitidis strains express a diverse range of lipopolysaccharide (LPS) structures that have been classified into 12 immunotypes. A feature of meningococcal LPS is the reversible, high-frequency switching of expression (phase variation) of terminal LPS structures. A number of studies are strongly suggestive of a key role for these terminal structures, and their phase-variable expression, in pathogenesis. In a previous study, a locus of three LPS biosynthetic genes, IgtABE, involved in the biosynthesis of one of these terminal structures, lacto-N-neotetraose, was described. The molecular mechanism of phase-variable expression of this structure is by high-frequency mutation in a homopolymeric tract of G residues in the IgtA gene. To investigate the genetic basis of the structural differences between the immunotypes, and the potential for strains to express alternative immunotypes, this locus was examined in all of the immunotype strains. Initially, the Igt locus of strain 126E, an L1 immunotype strain, was cloned and sequenced, revealing two active genes, IgtC and IgtE. The remnants of the IgtA and IgtB genes and an inactive IgtD gene were also present, indicating that the locus may have once contained five active genes, similar to a locus previously reported in Neisseria gonorrhoeae strain F62. Probes based on each of the Igt genes (ABCDE), and the recently reported IgtG gene, were used to determine the presence or absence of Igt genes within individual strains, allowing the prediction of the phase variation repertoire of these strains. Sequencing to determine the nature of homopolymeric tract regions within the Igt genes was carried out to establish the potential for LPS switching. In general, the set of strains examined could be sorted into two distinct groups: one group which phase-vary the alpha-chain extension via IgtA or IgtC but cannot make beta-chain; the second group phase-vary the beta-chain extension via IgtG but do not vary alpha-chain (lacto-N-neotetraose).
Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder (2009)

The phenotypic spectrum associated with CNV at 16p11.2 includes ASD, MR/DD and/or possibly other primary psychiatric disorders. Compared with the microduplications, the reciprocal microdeletions are more likely to be penetrant and to be associated with non-specific major or minor dysmorphism. There are deletion positive ASD probands with a less severe phenotype than deletion negative ASD siblings underscoring the significant phenotypic heterogeneity.