gebhart/patrepeval huggingface dataset:
Opportunities for nanotechnology to enhance electrochemical treatment of pollutants in potable water and industrial wastewater – a perspective (2020)

An international workshop identified how pore structures and unique properties that emerge at nano- to sub-nano- size domains can improve the energy efficiency and selectivity of electroseparation or electrocatalytic processes for treating water.
Assessment of the Electronic Factors Determining the Thermodynamics of “Oxidative Addition” of C–H and N–H Bonds to Ir(I) Complexes (2015)

A study of electronic factors governing the thermodynamics of C-H and N-H bond addition to Ir(I) complexes was conducted. DFT calculations were performed on an extensive series of trans-(PH3)2IrXL complexes (L = NH3 and CO; X = various monodentate ligands) to parametrize the relative σ- and π-donating/withdrawing properties of the various ligands, X. Computed energies of oxidative addition of methane to a series of three- and four-coordinate Ir(I) complexes bearing an ancillary ligand, X, were correlated with the resulting (σ(X), π(X)) parameter set. Regression analysis indicates that the thermodynamics of addition of methane to trans-(PH3)2IrX are generally strongly disfavored by increased σ-donation from the ligand X, in contradiction to widely held views on oxidative addition. The trend for oxidative addition of methane to four-coordinate Ir(I) was closely related to that observed for the three-coordinate complexes, albeit slightly more complicated. The computational analysis was found to be consistent with the rates of reductive elimination of benzene from a series of isoelectronic Ir(III) phenyl hydride complexes, measured experimentally in this work and previously reported. Extending the analysis of ancillary ligand energetic effects to the oxidative addition of ammonia to three-coordinate Ir(I) complexes leads to the conclusion that increasing σ-donation by X also disfavors oxidative addition of N-H bonds to trans-(PH3)2IrX. However, coordination of NH3 to the Ir(I) center is disfavored even more strongly by increasing σ-donation by X, which explains why the few documented examples of H-NH2 oxidative addition to transition metals involve complexes with strongly σ-donating ligands situated trans to the site of addition. An orbital-based rationale for the observed results is presented.
Eyewitness (2015)

We present a methodology for automatically extracting and summarizing reports of significant local events from large-scale Twitter feeds. While previous work has relied on an analysis of tweet text to identify local events, we show how to reliably detect events using only time series analysis of geotagged tweet volumes from localized regions. The algorithm sweeps through different spatial and temporal resolutions and finds events as anomalous spikes in the rate of geotagged tweets. We applied the approach to a corpus of over 733 million geotagged tweets. Using a panel of 103 crowdsourced judges who tagged 2400 detected events, we achieved a local event detection precision of 70%. Using these judged events as ground truth, a decision tree classifier was able to raise the detection precision to 93%.
Integrated optic frequency shifters for space heterodyne interferometry (1998)

Heterodyne interferometer laser gauges are used in space- based astronomical interferometers to very accurately measure and compensate for variations in starlight pathlength. Bragg cells have been traditionally used to generate the heterodyne signal by shifting the frequency of the laser light. This paper presents the development and qualification of an integrated optic frequency shifter (IOFS) which offers improved performance and reliability compared with Bragg cell technology. The most critical advantage of the IOFS for space applications is that it enables fiber optic metrology source integration, which facilitates the integration process and result in more reliable and compact heterodyne interferometer laser gauges.
Route of Administration Determines Induction of T-Cell-Independent Humoral Responses to Adeno-Associated Virus Vectors (2000)

Vectors based on adeno-associated viruses (AAV) type 2 show promise for treating chronic diseases because transgene expression appears to be stable. This study evaluated the impact of humoral immunity to the capsid proteins on vector uptake by hepatocytes following an intravascular approach. Route of vector administration in mice had a qualitative effect on antivector B cell responses. Administration of vector into the tail vein resulted in T-cell-dependent (TD) B cell responses that were completely inhibited with depleting CD4 antibody. Delivery of vector into the portal circulation via the spleen yielded B cell response that were partially T cell independent (TI) rendering strategies based on T cell inhibition ineffective in allowing vector readministration. The TI B cell response was short lived in comparison to the TD response. Rhesus monkeys produced a B cell memory response to intraportal vector which appeared to be T cell dependent based on Ig isotypes. Gene therapy strategies that require AAV vector readministration should consider vector biodistribution and its impact on B cell activation.
Ten years of MISR observations from Terra: Looking back, ahead, and in between (2010)

The Multi-angle Imaging SpectroRadiometer (MISR) instrument has been collecting global Earth data from NASA's Terra satellite since February 2000. With its nine along-track view angles, four visible/near-infrared spectral bands, intrinsic spatial resolution of 275 m, and stable radiometric and geometric calibration, no instrument that combines MISR's attributes has previously flown in space. The more than 10-year (and counting) MISR data record provides unprecedented opportunities for characterizing long-term trends in aerosol, cloud, and surface properties, and includes 3-D textural information conventionally thought to be accessible only to active sensors.
Chromium Poisoning Effects on Surface Exchange Kinetics of La0.6Sr0.4Co0.2Fe0.8O3-X (2016)

Solid oxide fuel cells (SOFC) have been demonstrated with high efficiency in energy conversion through electrochemical reactions. However, the durability of SOFC cathodes under real operating conditions is still an important issue for widespread implementation. Chromium-containing interconnect alloys have been reported to cause severe degradations and restrain cathode performance. Also, the presence of both chromium and water vapor have been shown to accelerate the degree of chromium poisoning. Therefore, fundamental understanding of chromium effects, as well as cross-contamination effects, on the oxygen reduction reaction (ORR) and the cathode degradation mechanism are important to preventing chromium poisoning. Here we utilize in-situ gas phase isotopic oxygen exchange to explore effect of chromium on the ORR mechanisms. Gas phase isotopic oxygen exchange is a powerful technique to investigate surface reaction kinetics and catalytic activity from a molecular point of view. To investigate Cr effects on the surface kinetics of cathodes, La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3-x (LSCF) powders had been aged in contact with Cr-containing alloy (Crofer APU 22) with the presence of water. Aged La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3-x (LSCF) powders were examined under different atmospheres and the effects of chromium on LSCF as a function of temperature with or without the presence of water vapor were explored. The use of gas phase isotopic oxygen offers separate examination of Cr effects on the surface dissociation step and the overall surface exchange on LSCF. The changes in active surface sites of aged LSCF could also be quantified. Cross-contamination and the lifetime of intermediate adsorbed species were further determined to elucidate multiple gas-gas and gas-solid reactions on cathodes. Results of surface kinetics show correlations with surface configurations of LSCF. A possible degradation mechanism has been proposed to illuminate chromium poisoning effects on the ORR.
On the Role of Bathocuproine in Organic Photovoltaic Cells (2008)

Abstract The effect of bathocuproine (BCP) on the optical and electrical properties of organic planar heterojunction photovoltaic cells is quantified by current–voltage characterization under 1 sun AM 1.5D simulated solar illumination and spectral response at short‐circuit conditions. By inserting a 10 nm BCP layer in an indium tin oxide (ITO)/subphthalocyanine (SubPc)/buckminsterfullerene (C 60 )/BCP/Al thin‐film structure, an increase in power‐conversion efficiency from 0.05 to 3.0% is observed, mostly reflected in the enhanced open‐circuit voltage up to 920 mV. Furthermore, the incorporation of a 10‐nm BCP layer in an ITO/C 60 /BCP/Al structure leads to an increase in built‐in potential from 250 to 850 mV, as demonstrated by electroabsorption. It is argued that BCP passivates C 60 such that a 10‐nm layer provides a sufficient buffer layer that prohibits Al contacting the C 60 where it would otherwise create donor states.
Spatially Reconfigurable Multimedia Platform Based on Auto-Localization in a Two-Dimensional Grid (2013)

An efficient mechanism to automatically configure the relative locations of distributed intelligent nodes which are arranged in a grid pattern is introduced in this paper. Through the developed approach, if an intelligent node knows the location of more than one neighboring node, its location can be identified. By harnessing the characteristics of the grid structure as well as the short-range infra-red signal communication between the adjacent nodes, the location of an intelligent node and the location map of the entire system are automatically configured at each node. Proposed algorithms in this study are tested through modularized and spatially reconfigurable multi-media platforms.
P3B-3 Staining Doppler Audio (2006)

Carotid stenoses are responsible for many of the strokes occurring each year. We have developed a low-cost-of-use instrument for use in primary-care physicians' offices that can detect these stenoses before they produce a stroke. Non-specialists are to use the instrument with only limited training, so it is desirable to make the Doppler audio it produces as easy to interpret as possible. We present two techniques for doing so by processing or "staining" the original audio signal to make it easier for neophyte operators to recognize the information present in the signal. In a small user study, a technique based on adaptive filtering did not result in an improvement, but another technique based on adding a sine tone of varying frequency to the signal produced a significant improvement in accuracy over the unstained Doppler audio. The study also showed that untrained subjects were capable of performing quite well even on unstained audio
Aeronautical to Ground Channel Modeling for Common Data Link (2016)

본 논문에서는 고속의 공용데이터링크(common data link, CDL)를 위한 새로운 채널 모델을 제안한다. 송신기의 고도가 수km ~ 수십km이고 통달거리가 수백km인 경우 지구 곡률에 의해 송신신호가 수신기의 앞 쪽에서 지면에 반사되어 들어오는 Two-ray 채널이 발생할 가능성이 크다. 송수신기의 빔포밍(beamforming) 각도와 안테나 방사 패턴(radiation pattern)에 따라 반사 경로로 들어오는 신호의 최대 지연 시간(maximum delay)과 전력 지연 프로파일(power delay profile)을 추정하여 Two-ray 채널을 모델링한다. 제안하는 채널 모델에서는 통달거리가 길기 때문에 전력 지연 프로파일이 최대 지연 시간보다 신호 대 잡음비(signal to noise ratio, SNR)에 대한 비트 오류율(bit error rate, BER)에 더 큰 영향을 미친다. The new channel model for high data rate common data link(CDL) is proposed. The Two-ray channel, which is composed of the reflected signals on the front ground of the receiver, is considered in this paper. This channel arises due to the curvature of the earth when the altitude of the transmitter is tens of kilometers and distance between the transmitter and the receiver is hundreds of kilometers. The Two-ray channel is modeled by estimating the maximum delay profile and the power delay profile, depending on the transmitting and receiving beamforming angle and the radiation pattern of antenna. The power delay profile has a larger effect on the bit error rate(BER) over signal to noise ratio(SNR) than the maximum delay profile, because the distance range is too long in the proposed channel model.
Oxide‐Based Solid‐State Batteries: A Perspective on Composite Cathode Architecture (2022)

Abstract The garnet‐type phase Li 7 La 3 Zr 2 O 12 (LLZO) attracts significant attention as an oxide solid electrolyte to enable safe and robust solid‐state batteries (SSBs) with potentially high energy density. However, while significant progress has been made in demonstrating compatibility with Li metal, integrating LLZO into composite cathodes remains a challenge. The current perspective focuses on the critical issues that need to be addressed to achieve the ultimate goal of an all‐solid‐state LLZO‐based battery that delivers safety, durability, and pack‐level performance characteristics that are unobtainable with state‐of‐the‐art Li‐ion batteries. This perspective complements existing reviews of solid/solid interfaces with more emphasis on understanding numerous homo‐ and heteroionic interfaces in a pure oxide‐based SSB and the various phenomena that accompany the evolution of the chemical, electrochemical, structural, morphological, and mechanical properties of those interfaces during processing and operation. Finally, the insights gained from a comprehensive literature survey of LLZO–cathode interfaces are used to guide efforts for the development of LLZO‐based SSBs.
Poster (2011)

Mobile sensing technologies present exciting opportunities for healthcare. Wireless sensors can automatically provide sensor data to care providers, dramatically improving their ability to diagnose, monitor, and manage a wide range of medical conditions. Using mobile phones to provide connectivity between sensors and providers is essential to keeping costs low and deployments simple. Unfortunately, software-based attacks against phones, which can have significant consequences for patients, are also on the rise.
Designing a 3D Printing Based Auxetic Cardiac Patch with hiPSC-CMs for Heart Repair (2021)

Myocardial infarction is one of the largest contributors to cardiovascular disease and reduces the ability of the heart to pump blood. One promising therapeutic approach to address the diminished function is the use of cardiac patches composed of biomaterial substrates and cardiac cells. These patches can be enhanced with the application of an auxetic design, which has a negative Poisson's ratio and can be modified to suit the mechanics of the infarct and surrounding cardiac tissue. Here, we examined multiple auxetic models (orthogonal missing rib and re-entrant honeycomb in two orientations) with tunable mechanical properties as a cardiac patch substrate. Further, we demonstrated that 3D printing based auxetic cardiac patches of varying thicknesses (0.2, 0.4, and 0.6 mm) composed of polycaprolactone and gelatin methacrylate can support induced pluripotent stem cell-derived cardiomyocyte function for 14-day culture. Taken together, this work shows the potential of cellularized auxetic cardiac patches as a suitable tissue engineering approach to treating cardiovascular disease.
Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies (1994)

The beta-amyloid or A4 protein is found deposited in neuritic plaques and neurofibrillary tangles in Alzheimer's disease (AD) affected brains and in the brains of adults with Down's Syndrome. The precursor to this 42 amino acid protein is the 695 amino acid long amyloid protein precursor (APP-695). Two additional APP species, APP-751 and APP-770, each contain a 56-amino-acid insert sequence that is analogous to Kunitz protease inhibitors. APP mRNA is widely distributed in both the human and rat brain, although the adult rat does not develop mature amyloid pathology. In this study we used antibodies against the N-terminus, junction site (unique to APP-695) insert sequence (unique to APP-751,-770), A4 region, and C-terminus of APP to immunolabel sections from throughout the young adult rat brain. From these results we constructed maps of the staining pattern of each antibody. We found that APP is widely distributed throughout the brain, that labelling is predominantly neuronal in character, and that there is marked variation among the antibodies in the extent of labelling, the particular cell populations stained, and the structures labelled within individual cells. The differential staining patterns observed with the five different antibodies suggest that the way APP is processed differs from one region to another and within different compartments in the cell. The specificity of the antibodies was established by Western blot analysis, in which APP species of approximately 95 and 110 kD were found. Our findings on the distribution of APP provide a foundation for further investigations into the normal role of APP and the pathogenesis of AD.
Optical Fiber Characterization for the Operation of a Boston Area Quantum Network Testbed (2022)

We characterize a set of deployed fiber channels in the Boston metro-area for use in quantum networking. We measure fiber-induced phase shifts and frequency behavior of transmitted optical signals.
Laser-Assisted Photoelectric Effect from Surfaces (2006)

We report the first observation of the laser-assisted photoelectric effect from a solid surface. By illuminating a Pt(111) sample simultaneously with ultrashort 1.6 eV and 42 eV pulses, we observe sidebands in the extreme ultraviolet photoemission spectrum. The magnitude of these sidebands as a function of time delay between the laser and extreme ultraviolet pulses represents a cross-correlation measurement of the extreme ultraviolet pulse. This effect promises to be useful to extend extreme ultraviolet pulse duration measurements to higher photon energies, as well as opening up femtosecond-to-attosecond time-scale electron dynamics in solid and surface-adsorbate systems.
Emerging Roles of S -Nitrosylation in Protein Misfolding and Neurodegenerative Diseases (2007)

Overactivation of N-methyl-D-aspartate (NMDA)-type glutamate receptors accounts, at least in part, for excitotoxic neuronal damage, potentially contributing to a wide range of acute and chronic neurologic disorders. Recent studies have suggested that generation of excessive nitric oxide (NO) and reactive oxygen species (ROS) can mediate excitotoxicity, in part by triggering protein misfolding. S-Nitrosylation, which is a covalent reaction of a NO group with a cysteine thiol, represents one such mechanism that can contribute to NO-induced neurotoxicity. The ubiquitin-proteasome system (UPS), in conjunction with molecular chaperones, can prevent accumulation of aberrantly-folded proteins. For example, protein disulfide isomerase (PDI) can provide neuroprotection from misfolded proteins or endoplasmic reticulum stress through its molecular chaperone and thiol-disulfide oxidoreductase activities. Here, the authors present recent evidence suggesting that NO contributes to degenerative conditions by S-nitrosylating PDI (forming SNO-PDI) and the ubiquitin protein ligase, parkin (forming SNO-parkin). Moreover, it is demonstrated for the first time that inhibition of excessive NMDA receptor activity by memantine, via a mechanism of uncompetitive open-channel block with a relatively rapid off-rate, can ameliorate excessive production of NO, protein misfolding, and neurodegeneration.
Stack-run coding with space-frequency quantization (2002)

The choice of quantization method in wavelet image compression is a crucial issue that affects performance, quality, and system design. Space-frequency scalar quantization of zero-trees achieves excellent coding efficiency. Stack-run coding is an efficient alternative to zero-trees which maintains independence between subbands. We present a new approach to wavelet quantization which enhances the stack-run coding method. Low addressing complexity, independence between subbands, and fast, parallel decoding are preserved while superior performance is obtained. The most important features are the optimization of dead-zone scalar quantizers, raster scan pattern selection, and the local (spatial) optimization of quantization coefficients. The local optimization is not spatially restricted (as with zero-trees) and new non-recursive optimal algorithms are now possible. Simulation results indicate that the new technique is strongly PSNR competitive with the best of current lossy wavelet image coders. The new framework also allows insight into the nature of the performance gains achieved by space-frequency quantization.
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures (2007)

The yeast prion protein Sup35 is a translation termination factor, whose activity is modulated by sequestration into a self-perpetuating amyloid. The prion-determining domain, NM, consists of two distinct regions: an amyloidogenic N terminus domain (N) and a charged solubilizing middle region (M). To gain insight into prion conversion, we used single-molecule fluorescence resonance energy transfer (SM-FRET) and fluorescence correlation spectroscopy to investigate the structure and dynamics of monomeric NM. Low protein concentrations in these experiments prevented the formation of obligate on-pathway oligomers, allowing us to study early folding intermediates in isolation from higher-order species. SM-FRET experiments on a dual-labeled amyloid core variant (N21C/S121C, retaining wild-type prion behavior) indicated that the N region of NM adopts a collapsed form similar to "burst-phase" intermediates formed during the folding of many globular proteins, even though it lacks a typical hydrophobic core. The mean distance between residues 21 and 121 was approximately equal to 43 A. This increased with denaturant in a noncooperative fashion to approximately equal to 63 A, suggesting a multitude of interconverting species rather than a small number of discrete monomeric conformers. Fluorescence correlation spectroscopy analysis of singly labeled NM revealed fast conformational fluctuations on the 20- to 300-ns time scale. Quenching from proximal and distal tyrosines resulted in distinct fast and slower fluctuations. Our results indicate that native monomeric NM is composed of an ensemble of structures, having a collapsed and rapidly fluctuating N region juxtaposed with a more extended M region. The stability of such ensembles is likely to play a key role in prion conversion.
RASSF6exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells (2014)

Brain metastasis is a major contributor to cancer mortality, yet, the genetic changes underlying the development of this capacity remain poorly understood. RASSF proteins are a family of tumor suppressors that often suffer epigenetic inactivation during tumorigenesis. However, their epigenetic status in brain metastases has not been well characterized. We have examined the promoter methylation of the classical RASSF members (RASSF1A-RASSF6) in a panel of metastatic brain tumor samples. RASSF1A and RASSF2 have been shown to undergo promoter methylation at high frequency in primary lung and breast tumors and in brain metastases. Other members exhibited little or no methylation in these tumors. In examining melanoma metastases, however, we found that RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases. Most melanomas are driven by an activating mutation in B-Raf. Introduction of RASSF6 into a B-Raf(V600E)-containing metastatic melanoma cell line inhibited its ability to invade through collagen and suppressed MAPK pathway activation and AKT. RASSF6 also appears to increase the association of mutant B-Raf and MST1, providing a potential mechanism by which RASSF6 is able to suppress MAPK activation. Thus, we have identified a novel potential role for RASSF6 in melanoma development. Promoter methylation leading to reduced expression of RASSF6 may play an important role in melanoma development and may contribute to brain metastases.