gebhart/patrepeval huggingface dataset:
Relationship between Cycle Length of Typical Atrial Flutter and Double Potential Interval after Achievement of Complete Isthmus Block (2010)

Background: There is some disagreement concerning the minimal value of the interval between components of double potentials (DPs interval) that allows distinguishing complete and incomplete block in the cavotricuspid isthmus (CTI). Objectives: To assess clinical utility of the relationship between atrial flutter cycle length (AFL CL) and the DPs interval. Methods: Ablation of the CTI was performed in 87 patients during AFL (245 ± 40 ms). Subsequently, DPs were recorded during proximal coronary sinus pacing at sites close to a gap in the ablation line and after achievement of complete isthmus block. Results: We noted strong correlation between AFL CL and the DPs interval after achievement of isthmus block (r = 0.73). The mean DPs interval was 95.3 ± 18.3 ms (range 60–136 ms) and 123.3 ± 24.3 ms (range 87–211 ms) during incomplete and complete isthmus block, respectively (P &lt; 0.001). When expressed as a percentage of AFL CL, this interval was 35.7 ± 3.5% AFL CL (range 28–40.2%) and 50.4 ± 6.9% AFL CL (range 39–72%) during incomplete and complete isthmus block, respectively (P &lt; 0.001). A cutoff value of 40% of AFL CL identified CTI block with 96.7% sensitivity and 100% specificity. Conclusions: The interval between DPs after achievement of block in the CTI correlates with AFL CL. The DPs interval expressed as a percentage of AFL CL allows better distinguishing between complete and incomplete isthmus block compared to standard method based on milliseconds. The DPs interval below 40% of AFL CL indicates sites close to a gap in the ablation line. (PACE 2010; 33:1518–1527)
How a branded website creates customer purchase intentions (2017)

This paper aims to investigate whether customers’ perceptions of the quality and brand equity of a branded website affect purchase intentions, and to explore the mediating effects of trust and perceived risk in this relationship. Links between purchase intention and both trust and perceived risk, moderated by electronic word of mouth (eWOM), are also examined. A research model for testing relationships among these constructs based on the stimulus-organism-response (S-O-R) framework is outlined. A statistical analysis of the collected questionnaires was computed from the website of a target chain restaurant in Taiwan (T.G.I. Friday’s). Structural equation modelling (SEM) was used to examine the hypothesised relationships among the variables. The findings confirm that potential customers’ perceptions of both the quality and brand equity of a branded website affect their trust and perceived risk, and, in turn, their purchase intentions. This study also reveals the existence of a moderating effect of eWOM on the links between both trust and perceived risk and purchase intentions. Based on the findings, the implications are discussed, and directions for future research are highlighted.
Cancellation of Discrete Time Unstable Zeros by Feedforward Control (1994)

This paper presents a design methodology for the cancellation of unstable zeros in linear discrete time systems with tracking control objectives. Unstable zeros are defined to be those zeros of the rational transfer function that occur outside the unit circle. Unstable zeros cannot be canceled by feedback without compromising stability. In light of this fact, a feedforward scheme is used. Future desired trajectory information is required because the feedforward scheme is noncausal. The amount of future desired trajectory information that is required depends upon the zero locations and design specifications. It is shown that for a known plant with no zeros on the unit circle one can obtain a frequency response arbitrarily close to 1. Robustness issues and simulation results are discussed.
Cryosurgery - a review of recent advances and current issues. (2002)

Advances in cryosurgery since 1990 were initiated by the development of improved cryosurgical equipment and by the availability of intraoperative ultrasound to monitor the tissue-freezing process. Interest in research on the effects of freezing on tissue and on new clinical applications was then stimulated. The research led to a better understanding of the mechanisms of cryogenic injury, including cell death by apoptosis, which has emerged as a potential key to the use of adjunctive chemotherapy in the treatment of cancer. Optimization of cryosurgical technique will also improve clinical results.
HF spectrum activity prediction model based on HMM for cognitive radio applications (2012)

Although most of the research on Cognitive Radio is focused on communication bands above the HF upper limit (30 MHz), Cognitive Radio principles can also be applied to HF communications to make use of the extremely scarce spectrum more efficiently. In this work we consider legacy users as primary users since these users transmit without resorting to any smart procedure, and our stations using the HFDVL (HF Data+Voice Link) architecture as secondary users. Our goal is to enhance an efficient use of the HF band by detecting the presence of uncoordinated primary users and avoiding collisions with them while transmitting in different HF channels using our broad-band HF transceiver. A model of the primary user activity dynamics in the HF band is developed in this work to make short-term predictions of the sojourn time of a primary user in the band and avoid collisions. It is based on Hidden Markov Models (HMM) which are a powerful tool for modelling stochastic random processes and are trained with real measurements of the 14 MHz band. By using the proposed HMM based model, the prediction model achieves an average 10.3% prediction error rate with one minute-long channel knowledge but it can be reduced when this knowledge is extended: with the previous 8 min knowledge, an average 5.8% prediction error rate is achieved. These results suggest that the resulting activity model for the HF band could actually be used to predict primary users activity and included in a future HF cognitive radio based station.
<title>Optical interconnects: a solution to very high speed integrated circuits and systems</title> (1991)

Optical interconnections in the intrachip, chip-to-chip, and board-to-board scenarios are investigated. A universal polymer waveguide formation method is developed. Tunability from the step index to the graded index of the polymer film makes it possible to construct planar and channel waveguides on any substrate including semiconductors, conductors, and insulators. A polymer waveguide modulator based on a current injection method is further developed. Modulation depth as high as 36 dB is achieved with an injection density of 1.8 micro-A/sq micron. A microprism coupler (about 125 microns) with a coupling bandwidth higher than 200 nm is developed to solve the interface problems among different interconnection schemes. Using this concept, optical waves from a single-mode waveguide can be successfully coupled to a multimode fiber.
Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa (2008)

In some Proteobacteria biogenesis of c-type cytochromes depends on the products of the ccmABCDEFG(H) genes, which encode inner-membrane proteins. Inactivation of some ccm genes, in particular ccmC, has an impact on other processes as well, including siderophore production and utilization. Non-polar insertions were generated in the Pseudomonas aeruginosa ccmA, ccmC, ccmE, ccmF and ccmH genes, and their impacts on different phenotypes were compared. Only in the case of the ccmC mutant was cytochrome c production totally abrogated. The ccmC mutant, and to a lesser extent the ccmF mutant, showed a range of other phenotypic changes. The production of the siderophore pyoverdine was very low and growth under the condition of iron limitation was severely restricted, but production of the second siderophore, pyochelin, was increased. Interestingly, other traits were also strongly affected by the ccmC mutation, including the production of pyocyanin, swarming and twitching motility, and rhamnolipid production. The production of N-acyl homoserine lactones or the Pseudomonas quinolone signal (PQS) was, however, not affected in the ccmC and ccmF mutants. The ccmC mutant was also found to accumulate porphyrins, and catalase production was undetectable, consistent with the increased sensitivity to hydrogen peroxide. Finally, reduction in the content of [Fe-S] clusters was evidenced in both ccmC and ccmF mutants. Wild-type phenotypes were restored by complementation with a ccmC gene from Pseudomonas fluorescens ATCC 17400. In conclusion, we have demonstrated that CcmC is a key determinant for cytochrome c biogenesis, pyoverdine maturation, and expression of some quorum sensing-regulated traits.
A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia (2019)

Several studies have demonstrated that LncRNAs can play major roles in cancer development. The creation of a catalog of LncRNAs expressed in T cell acute lymphoblastic leukemia (T-ALL) is thus of particular importance. However, this task is challenging as LncRNA expression is highly restricted in time and space manner and thus may greatly differ between samples. We performed a systematic transcript discovery in RNA-Seq data obtained from T-ALL primary cells and cell lines. This led to the identification of 2560 novel LncRNAs. After the integration of these transcripts into a large compendium of LncRNAs (<i>n</i> = 30478) containing both known LncRNAs and those previously described in T-ALLs, we then performed a systematic genomic and epigenetic characterization of these transcript models demonstrating that these novel LncRNAs share properties with known LncRNAs. Finally, we provide evidence that these novel transcripts could be enriched in LncRNAs with potential oncogenic effects and identified a subset of LncRNAs coregulated with T-ALL oncogenes. Overall, our study represents a comprehensive resource of LncRNAs expressed in T-ALL and might provide new cues on the role of lncRNAs in this type of leukemia.
Gluteal-Sparing Approach for Posterior Iliac Crest Bone Graft (2010)

Although it is difficult to directly compare our results to those reported in other studies, we conclude that the rate of significant chronic sequelae related to this method of harvesting bone from the posterior iliac crest is low. Our findings may be due to the avoidance in this technique of disruption of the gluteal musculature and preservation of the lateral wall of the ilium. The methods used in other studies to estimate the prevalence of chronic pain related to posterior iliac crest bone grafting after lumbar spinal surgery may grossly overestimate this prevalence.
Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum (2018)

The newly identified mouse models for onchocerciasis will enable the development of O. volvulus specific biomarkers, screening for new therapeutic approaches and potentially studying the human immune response to infection with O. volvulus.
Integration of Perforated Subretinal Prostheses With Retinal Tissue (2015)

In retinas with photoreceptor degeneration, solid implants, or those with 5-μm perforations lead to the best biocompatibility.
Ultrasensitive thermo-mechanical bolometer (2023)

A thermo-mechanical bolometer includes a substrate and a sensing component mounted on the substrate. The sensing element comprises (a) at least one thermal-actuation component mounted in parallel with the substrate and (b) a strain sensor mounted on the at least one layer of thermal-actuation component. The at least one thermal-actuation component alone or in combination (a) absorbs electromagnetic waves and converts energy from absorbed electromagnetic waves into a change in temperature and (b) converts the change in temperature into a deformation of the at least one layer. The strain sensor comprises a layer of fragments with a gap space between the fragments, wherein the strain sensor senses the deformation or mechanical movement and exhibits a change in electrical resistance in response to the sensed deformation or mechanical movement.
Climate Impact on Plankton Ecosystems in the Northeast Atlantic (2004)

2.5 A to 20.0 A arestudied. The resulting protein conﬁgurations arethensolvatedinawaterbox,withwaterlayersatleast8Afromtheproteinsurfaces.Figure1showsonesuchsolvatedconﬁguration.EightNa coun-terionsareaddedtomakethesystemelectricallyneutral.Thesolvatedproteinsystemshaveupto42,000atoms(theactualsizevariesfordifferentinterdomaindistances).TheGROMACSsimulationpackageisusedhereforthislargesystembecauseof its fast speed (
All-Epitaxial Integration of Long-Wavelength Infrared Plasmonic Materials and Detectors for Enhanced Responsivity (2020)

Infrared detectors using monolithically integrated doped semiconductor “designer metals” are proposed and experimentally demonstrated. We leverage the “designer metal” groundplanes to form resonant cavities with enhanced absorption tuned across the long-wave infrared (LWIR). Detectors are designed with two target absorption enhancement wavelengths: 8 and 10 μm. The core of our detectors are quantum-engineered LWIR type-II superlattice p-i-n detectors with total thicknesses of only 1.42 and 1.80 μm for the 8 and 10 μm absorption enhancement devices, respectively. Our 8 and 10 μm structures show peak external quantum efficiencies of 45 and 27%, which are 4.5× and 2.7× enhanced, respectively, compared to control structures. We demonstrate the clear advantages of this detector architecture, both in terms of ease of growth/fabrication and enhanced device performance. The proposed architecture is absorber- and device-structure agnostic, much thinner than state-of-the-art LWIR T2SLs, and offers the opportunity for the integration of low dark current LWIR detector architectures for significant enhancement of IR detectivity.
Diagnosis and Management of Waldenstrom's Macroglobulinemia (2005)

WM is a distinct low-grade lymphoproliferative disorder. When therapy is indicated, alkylating agents, nucleoside analogs, and rituximab are reasonable choices. Several factors, including the presence of cytopenias, need for rapid disease control, candidacy for ASCT, age, and comorbidities, should be taken into consideration when choosing the most appropriate primary treatment.
Synergistic Sphere-to-Rod Micelle Transition in Mixed Solutions of Sodium Dodecyl Sulfate and Cocoamidopropyl Betaine (2004)

Static and dynamic light scattering experiments show that the mixed micelles of sodium dodecyl sulfate (SDS) and cocoamidopropyl betaine (CAPB) undergo a sphere-to-rod transition at unexpectedly low total surfactant concentrations, about 10 mM. The lowest transition concentration is observed at molar fraction 0.8 of CAPB in the surfactant mixture. The transition brings about a sharp increase in the viscosity of the respective surfactant solutions due to the growth of rodlike micelles. Parallel experiments with mixed solutions of CAPB and sodium laureth sulfate (sodium dodecyl-trioxyethylene sulfate, SDP3S) showed that the sphere-to-rod transition in SDP3S/CAPB mixtures occurs at higher surfactant concentrations, above 40 mM. The observed difference in the transition concentrations for SDS and SDP3S can be explained by the bulkier SDP3S headgroup. The latter should lead to larger mean area per molecule in the micelles containing SDP3S and, hence, to smaller spontaneous radius of curvature of the micelles (i.e., less favored transition from spherical to rodlike micelles). The static light scattering data are used to determine the mean aggregation number and the effective size of the spherical mixed SDS/CAPB micelles. From the dependence of the aggregation number on the surfactant concentration, the mean energy for transfer of a surfactant molecule from a spherical into a rodlike micelle is estimated.
The CD8β polypeptide is required for the recognition of an altered peptide ligand as an agonist (1996)

T cell activation is triggered by the specific recognition of cognate peptides presented by MHC molecules. Altered peptide ligands are analogs of cognate peptides which have a high affinity for MHC molecules. Some of them induce complete T cell responses, i.e. they act as agonists, whereas others behave as partial agonists or even as antagonists. Here, we analyzed both early (intracellular Ca2+ mobilization), and late (interleukin-2 production) signal transduction events induced by a cognate peptide or a corresponding altered peptide ligand using T cell hybridomas expressing or not the CD8 alpha and beta chains. With a video imaging system, we showed that the intracellular Ca2+ response to an altered peptide ligand induces the appearance of a characteristic sustained intracellular Ca2+ concentration gradient which can be detected shortly after T cell interaction with antigen-presenting cells. We also provide evidence that the same altered peptide ligand can be seen either as an agonist or a partial agonist, depending on the presence of CD8beta in the CD8 co-receptor dimers expressed at the T cell surface.
High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons (1995)

Journal Article High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons Get access Jesús Sainz, Jesús Sainz Search for other works by this author on: Oxford Academic PubMed Google Scholar Karla Figueroa, Karla Figueroa Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael E.Baser, Michael E.Baser Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor-F. Mautner, Victor-F. Mautner 1Krankenhaus OchsenzollHamburg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Stefan-Matthias Pulst Stefan-Matthias Pulst * * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 4, Issue 1, January 1995, Pages 137–139, https://doi.org/10.1093/hmg/4.1.137 Published: 01 January 1995 Article history Revision received: 02 November 1994 Accepted: 02 November 1994 Published: 01 January 1995
Wideband diode-based reconfigurable matching network operating at 36 dBm input power (2012)

This paper presents wideband reconfigurable matching networks operating at high power in the GSM850 and GSM900 bands to counteract the detuning of mobile handset antennas caused by user interaction. High breakdown voltage varactor diodes are used as tuning elements. Single-diode, shunt-series diode, and two-diode topologies are investigated for power handling, and the effect of input power on matching network transducer gain, G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> , is studied. Results show that a shunt-series diode topology can handle input powers of up to 36 dBm while maintaining G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> degradation of less than 0.1 dB.
76. Epigenetic Alterations in the Dystrophic Muscle Environment Down-Regulate rAAV-Mediated Transgene Expression (2013)

Jean Baptiste Dupont,1 Benoit Tournaire,1 Christophe Georger,2 Laetitia Van Wittenberghe,2 Beatrice Marolleau,2 Laurence Dubreil,3 Emilie Lecomte,1 Fulvio Mavilio,2 Richard O. Snyder,4,5 Philippe Moullier,1,4 Adrien Leger.1
Combustion Behavior Analysis in a Transparent Research Engine Equipped with a Common Rail Diesel Injection System (2000)

&lt;div class="htmlview paragraph"&gt;This paper describes a preliminary characterization of in-cylinder spray and combustion behavior from a high-pressure common rail injection system. The engine used in the tests was a single-cylinder optical research diesel engine, adequately developed in a full-fired version, equipped with a common rail injection system. An elongated piston allows for the optical access to the combustion chamber for diagnostic applications.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Characteristic of the optical engine is the availability to investigate different combustion system designs due to an interchangeable head-cylinder group. The system configuration tested in the present work corresponds to a four-cylinder engine of 1930 cc of displacement that is representative in the class of light duty d.i. diesel engine.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Spray and combustion evolutions were visualized through a high-speed CCD camera synchronized with a copper vapor laser acting as light source. Tests were performed at fixed engine speed and injected fuel mass (1500 rpm and 12.4 mg/stroke) but varying injector configuration (holes number and size).&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;As expected, pilot activation strongly affects spray and combustion evolution of subsequent main injection. Pilot seems to be characterized by small penetration and quick evaporation, burning almost completely before the main injection occurs.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Spray distribution of main injection appears to be influenced by pilot activation and injector configuration. In particular, the change of the nozzle configuration results in different spray patterns.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Due to a marked influence of pilot injection on whole combustion process, pilot parameter setting values should be chosen adequately in view of engine emission optimization.&lt;/div&gt;
Overview of recent Grid Codes for PV power integration (2012)

The challenge to bring down the cost of produced photovoltaic (PV) power had a major impact on the PV market and in consequence the grid operators experienced higher and higher PV power penetration. The growing share of this decentralized generation plants started to affect the grid stability and Distribution System Operators (DSOs) had to keep the safety and reliability of the network under strict rules and regulations. The aim of the paper is to realize a survey of recent Grid Codes (GC) and regulations for grid connected PV systems. The focus is on grid interface requirements, power quality concerns and Anti-Islanding (AI) issues regarding PV systems connected to low voltage (LV) and medium voltage (MV) levels of the network.
Fiber Fabry-Perot tunable filter for high-speed optical packet switching (1997)

Tunable optical filters are important building blocks for All-Optical systems and networks. Fast optical tuning in several microseconds is necessary to perform high-speed optical packet switching. Multi- Gigabit/sec packet-switching will provide flexibility and higher network throughput when large numbers of users communicate simultaneously. One approach to achieve fast wavelength tuning is to use high-speed piezoelectrically-driven Fiber Fabry-Perot tunable filters (FFP-TFs). The requirement for tuning in microseconds raises a whole new set of challenges, such as ringing, thermostability and mechanical inertia control. It was shown that correlation between the mechanical resonance and optical response of the filter is important for the filter`s speed and for mounting hardware and control circuitry optimization. These features together with the FFP-TF`s high capacitance (approximately 0.25-0.5 microfarad) are being folded into building a special controller to substantially improve the shape of the driving signal and the response of the filter. The resultant controller enables tuning the high-speed FFP-TF three-orders-of- magnitude faster than that possible with standard commercial FFP-TFS. The fastest switching time achieved is 2.5 microseconds. As the result, a new packet-switched media access control protocol is being designed to minimize the searching time. The filter scans only once through the entire optical region and then tunes to all the required channels one after another in a few microseconds. It can help update Rainbow-2 Broadcast-and-Select High-Speed Wavelength Division Multiplexing All-Optical network that currently has a circuit- switched protocol using standard FFP-TFS.