gebhart/patrepeval huggingface dataset:
Synthesis of 2-[(perfluoroalkyl)phenyl]propionic acids (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-[(perfluoroalkyl)phenyl]propionic acidsG. Patrick Stahly and Andrew JacksonCite this: J. Org. Chem. 1991, 56, 18, 5472–5475Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jo00018a055https://doi.org/10.1021/jo00018a055research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Prostate cancer survivors with symptoms of radiation cystitis have elevated fibrotic and vascular proteins in urine (2020)

Radiation for pelvic cancers can result in severe bladder damage and radiation cystitis (RC), which is characterized by chronic inflammation, fibrosis, and vascular damage. RC development is poorly understood because bladder biopsies are difficult to obtain. The goal of this study is to gain understanding of molecular changes that drive radiation-induced cystitis in cancer survivors using urine samples from prostate cancer survivors with history of radiation therapy. 94 urine samples were collected from prostate cancer survivors with (n = 85) and without (n = 9) history of radiation therapy. 15 patients with radiation history were officially diagnosed with radiation cystitis. Levels of 47 different proteins were measured using Multiplex Luminex. Comparisons were made between non-irradiated and irradiated samples, and within irradiated samples based on radiation cystitis diagnosis, symptom scores or hematuria. Statistical analysis was performed using Welch's t-test. In prostate cancer survivors with history of radiation therapy, elevated levels of PAI 1, TIMP1, TIMP2, HGF and VEGF-A were detected in patients that received a radiation cystitis diagnosis. These proteins were also increased in patients suffering from hematuria or high symptom scores. No inflammatory proteins were detected in the urine, except in patients with gross hematuria and end stage radiation cystitis. Active fibrosis and vascular distress is detectable in the urine through elevated levels of associated proteins. Inflammation is only detected in urine of patients with end-stage radiation cystitis disease. These results suggest that fibrosis and vascular damage drive the development of radiation cystitis and could lead to the development of more targeted treatments.
Low Complex Inter-Doppler Interference Mitigation for OTFS Systems via Global Receiver Windowing (2023)

Orthogonal time frequency space (OTFS) waveform has been considered as a potential candidate for affording a wide range of emerging communications and sensing applications in beyond 5G wireless technologies. OTFS takes advantage of both time and frequency selectivity of the doubly dispersive wireless environment, which has been considered as one of the limiting factors in classical wireless communication technologies. However, the performance of OTFS-based wireless systems is severely affected by fractional Doppler that arises due to inevitable and inherent characteristics of the wireless channel taps of not being always integer Doppler values in the delay-Doppler plane. Thus, this results in severe inter-Doppler interference (IDI) and a low channel sparsity in delay-Doppler (DD) domain. To this end, this work introduces a novel receiver (Rx) windowing technique to combat the impact of fractional Doppler on error performance of the OTFS-based transmission with practical pulse shaping filters at the transceiver. Specifically, we introduce a global cyclic prefix (CP) based raised cosine (RC) windowing at Rx in order to alleviate the effect of IDI on the received signal. To do so, the proposed scheme changes the pulse shape of the OTFS signal in DD domain that defines the IDI level and sparsity of the effective channel. Furthermore, we assess the performance of the proposed Rx windowed OTFS (RW-OTFS) scheme under various practical communication scenarios. The obtained numerical and simulation results validate the accuracy of the proposed IDI mitigator for OTFS systems in practical high-mobility scenarios.
21 Biotinylation and fluorescein labelling of angiotensin II (1991)

s: Xth journees de I'Hypertension Arterielle Annual Scientific Meeting of the French Society of Hypertension,Section of the French Society of Cardiology Pairs, France: PDF Only
A 2.2M CMOS image sensor for high-speed machine vision applications (2010)

This paper describes a 2.2 Megapixel CMOS image sensor made in 0.18 &mu;m CMOS process for high-speed machine vision applications. The sensor runs at 340 fps with digital output using 16 LVDS channels at 480MHz. The pixel array counts 2048x1088 pixels with a 5.5um pitch. The unique pixel architecture supports a true correlated double sampling, thus yields a noise level as low as 13 e- and a pixel parasitic light sensitivity (PLS) of 1/60 000. The sensitivity of the sensor is measured to be 4.64 Vlux.s and the pixel full well charge is 18k e-.
Abstract P1-06-11: A targetable EGFR-driven tumor-initiating program in breast cancer (2017)

Abstract Background: Inter- and intra-tumour heterogeneity underlies variability in therapeutic response. Although targeting of the epidermal growth factor receptor (EGFR) in breast cancer has failed to demonstrate clinical efficacy at the population level, complete and durable responses have been reported at low frequencies. The molecular determinants of these responses are unknown, but are of importance in the era of precision medicine. Results: We performed a patient-derived xenograft (PDX) clinical trial with gefitinib in a breast cancer PDX cohort. Consistent with clinical trial data, gefitinib exhibited limited efficacy across most models. One PDX, however, demonstrated a complete and durable (&amp;gt;6 months) clinical response, and was subject to deep molecular profiling to identify determinants of response. Exome sequencing revealed no single nucleotide variants or copy number alterations in EGFR pathway members. EGFR was differentially expressed between the two major cellular subpopulations identified by single-cell RNAseq and this cellular heterogeneity in EGFR expression was validated immunohistochemically. Fluorescence-activated cell sorting of the EGFRhi subpopulation revealed cells with enhanced stem-like properties, including ALDH activity, sphere-forming capacity in vitro, ability to form tumours in vivo and seeding lung micrometastases from orthotopically transplanted tumours. Tumourspheres derived from EGFRhi cells developed into mixed EGFRhi and EGFRlo subpopulations, as did macrometastases, supporting that EGFRhi subpopulation can self-renew and re-populate. Analysis of expressed SNVs in the single-cell RNAseq data, filtered by variants identified from exome sequencing, showed no clonal segregation, supporting a non-clonal origin of the functionally distinct EGFRhi and EGFRlo subpopulations. This EGFR-driven tumour initiating cell program was observed in independent PDX models, some which showed growth inhibition in response to gefitinib. Conclusions: Using bulk and single-cell genomic profiling, we identified and functionally validated an EGFR-driven tumour-initiating program in a subset of aggressive breast tumours, which may be predictive of gefitinib sensitivity. This contradicts traditional beliefs that good therapeutic targets are homogenously expressed, in that we show that a target displaying intra-tumour heterogeneity can be effective so long that it is expressed in the tumour-initiating population. Citation Format: Savage P, Saleh SMI, Wang Y-C, Revil T, Badescu D, Liu L, Iacucci E, Zuo D, Bertos N, Munoz-Ramos V, Asselah J, Meterissian S, Omeroglu A, Hébert S, Kleinman C, Park M, Ragoussis J. A targetable EGFR-driven tumor-initiating program in breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P1-06-11.
Large-Scale Pattern Discovery in Music (2013)

This work focuses on extracting patterns in musical data from very large collections. The problem is split in two parts. First, we build such a large collection, the Million Song Dataset, to provide researchers access to commercial-size datasets. Second, we use this collection to study cover song recognition which involves finding harmonic patterns from audio features. Regarding the Million Song Dataset, we detail how we built the original collection from an online API, and how we encouraged other organizations to participate in the project. The result is the largest research dataset with heterogeneous sources of data available to music technology researchers. We demonstrate some of its potential and discuss the impact it already has on the field. On cover song recognition, we must revisit the existing literature since there are no publicly available results on a dataset of more than a few thousand entries. We present two solutions to tackle the problem, one using a hashing method, and one using a higher-level feature computed from the chromagram (dubbed the 2DFTM). We further investigate the 2DFTM since it has potential to be a relevant representation for any task involving audio harmonic content. Finally, we discuss the future of the dataset and the hope of seeing more work making use of the different sources of data that are linked in the Million Song Dataset. Regarding cover songs, we explain how this might be a first step towards defining a harmonic manifold of music, a space where harmonic similarities between songs would be more apparent.
Design of a dynamic calibration phantom to be used to calculate the temporal resolution of a tomographic imaging device (2008)

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.
Crystallographic Characterization of Helical Secondary Structures in α/β-Peptides with 1:1 Residue Alternation (2008)

Oligomers that contain both alpha- and beta-amino acid residues in a 1:1 alternating pattern have recently been shown by several groups to adopt helical secondary structures in solution. The beta-residue substitution pattern has a profound effect on the type of helix formed and the stability of the helical conformation. On the basis of two-dimensional NMR data, we have previously proposed that beta-residues with a five-membered ring constraint promote two different types of alpha/beta-peptide helix. The "11-helix" contains i, i+3 CO...H-N hydrogen bonds between backbone amide groups; these hydrogen bonds occur in 11-atom rings. The alpha/beta-peptide "14/15-helix" contains i, i+4 CO...H-N hydrogen bonds, which occur in alternating 14- and 15-atom rings. Here we provide crystallographic data for 14 alpha/beta-peptides that form the 11-helix and/or the 14/15-helix. These results were obtained for a series of oligomers containing beta-residues derived from ( S,S)- trans-2-aminocyclopentanecarboxylic acid (ACPC) and alpha-residues derived from alpha-aminoisobutyric acid (Aib) or l-alanine (Ala). The crystallized alpha/beta-peptides range in length from 4 to 10 residues. Nine of the alpha/beta-peptides display the 11-helix in the solid state, three display the 14/15-helix, and two display conformations that contain both i, i+3 and i, i+4 CO...H-N hydrogen bonds, but not bifurcated hydrogen bonds. Only 3 of the 14 crystal structures presented here have been previously described. These results suggest that longer alpha/beta-peptides prefer the 14/15-helix over the 11-helix, a conclusion that is consistent with previously reported NMR data obtained in solution.
Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry (2021)

Our knowledge of prostate cancer (PCa) genomics mainly reflects European (EUR) and Asian (ASN) populations. Our understanding of the influence of Middle Eastern (ME) and African (AFR) ancestry on the mutational profiles of prostate cancer is limited. To characterize genomic differences between ME, EUR, ASN, and AFR ancestry, fluorescent in situ hybridization (FISH) studies for <i>NKX3-1</i> deletion and MYC amplification were carried out on 42 tumors arising in individuals of ME ancestry. These were supplemented by analysis of genome-wide copy number profiles of 401 tumors of all ancestries. FISH results of <i>NKX3-1</i> and <i>MYC</i> were assessed in the ME cohort and compared to other ancestries. Gene level copy number aberrations (CNAs) for each sample were statistically compared between ancestry groups. <i>NKX3</i>-1 deletions by FISH were observed in 17/42 (17.5%) prostate tumors arising in men of ME ancestry, while <i>MYC</i> amplifications were only observed in 1/42 (2.3%). Using CNAs called from arrays, the incidence of <i>NKX3-1</i> deletions was significantly lower in ME vs. other ancestries (20% vs. 52%; <i>p</i> = 2.3 × 10<sup>-3</sup>). Across the genome, tumors arising in men of ME ancestry had fewer CNAs than those in men of other ancestries (<i>p</i> = 0.014). Additionally, the somatic amplification of 21 specific genes was more frequent in tumors arising in men of ME vs. EUR ancestry (two-sided proportion test; Q < 0.05). Those included amplifications in the glutathione S-transferase family on chromosome 1 (<i>GSTM1</i>, <i>GSTM2</i>, <i>GSTM5</i>) and the IQ motif-containing family on chromosome 3 (<i>IQCF1</i>, <i>IQCF2</i>, <i>IQCF13</i>, <i>IQCF4</i>, <i>IQCF5</i>, <i>IQCF6</i>). Larger studies investigating ME populations are warranted to confirm these observations.
Modeling the Effects of Ion Association on Alternating Current Impedance of Solid Polymer Electrolytes (2002)

This work presents a rigorous continuum model describing the transport of ions and associated ion pairs in solid polymer electrolytes subjected to small amplitude alternating current (ac) excitation. The model treats ion association as a reversible reaction among ions and ion pairs. Dimensionless governing equations are developed from component mass balances, flux equations based on dilute solution theory, and the Poisson equation. Assuming reversible electrode reactions and electroneutrality, the model equations have an analytical solution. Further simplifications are possible in limiting cases (weak and strong association, zero and infinite frequency excitation), giving expressions consistent with previously published models. We use the model to explore the effect of association/dissociation reaction rates, ion pair diffusivity, and fractional dissociation on ac impedance behavior. We present a scheme for establishing component diffusivities and fractional dissociation from independent experimental data for lithium perchlorate in poly(ethylene oxide). With no additional adjusted parameters, satisfactory agreement exists between calculated and experimental ac impedance data. © 2002 The Electrochemical Society. All rights reserved.
In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones. (2020)

Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs.
Wheat IgE profiling and wheat IgE levels in bakers with allergic occupational phenotypes (2013)

Wheat IgE levels and wheat microarrayed allergens may be associated with some occupational allergic phenotypes. The extension of the panel of wheat allergens may be promising for discriminating the clinical manifestations of baker's allergy.
Reconsidering the Polycystic Ovary Syndrome (PCOS) (2022)

Though likely the most common clinical diagnosis in reproductive medicine, the Polycystic Ovary Syndrome (PCOS) is still only poorly understood. Based on previously published research, and here newly presented supportive evidence, we propose to replace the four current phenotypes of PCOS with only two entities-a hyperandrogenic phenotype (H-PCOS) including current phenotypes A, B, and C, and a hyper-/hypoandrogenic phenotype (HH-PCOS), representing the current phenotype D under the Rotterdam criteria. Reclassifying PCOS in this way likely establishes two distinct genomic entities, H-PCOS, primarily characterized by metabolic abnormalities (i.e., metabolic syndrome) and a hyperandrogenic with advancing age becoming a hypoandrogenic phenotype (HH-PCOS), in approximately 85% characterized by a hyperactive immune system mostly due to autoimmunity and inflammation. We furthermore suggest that because of hypoandrogenism usually developing after age 35, HH-PCOS at that age becomes relatively treatment resistant to in vitro fertilization (IVF) and offer in a case-controlled study evidence that androgen supplementation overcomes this resistance. In view of highly distinct clinical presentations of H-PCOS and HH-PCOS, polygenic risk scores should be able to differentiate between these 2 PCOS phenotypes. At least one clustering analysis in the literature is supportive of this concept.
CyberKnife for hilar lung tumors: report of clinical response and toxicity (2010)

CyberKnife radiosurgery is an effective palliative treatment option for hilar lung tumors, but local control is poor at one year. Maximum point doses to critical structures may be used as a guide for limiting toxicities. Preliminary results suggest that dose escalation alone is unlikely to enhance the therapeutic ratio of hilar lung tumors and novel approaches, such as further defining the patient population or employing the use of radiation sensitizers, should be investigated.
Synthesis, Characterization, and Photophysical Properties of Os(II) Diimine Complexes [Os(N∧N)(CO)2I2] (N∧N = Bipyridine, Phenanthroline, and Pyridyl Benzoxazole) (2005)

A new series of Os(II) diimine complexes with the general formula [Os(N(wedge)N)(CO)(2)I(2)], N(wedge)N = 2,2'-bipyridine (bpy) (1), 4,4'-di-tert-butyl-2,2'-bipyridine (dbubpy) (2), 4,7-diphenyl-1,10-phenanthroline (dpphen) (3), 2-(2'-pyridyl)benzoxazole (pboz) (4), and 5-tert-butyl-2-(2'-pyridyl)benzoxazole (bupboz) (5), were synthesized and characterized by spectroscopic methods and by a single-crystal X-ray diffraction study on the dpphen complex 3. The corresponding photophysical properties were studied using UV-vis and emission spectrometry. The resulting phosphorescence features both in solution and as a solid film, in combination with the MO calculation, lead us to conclude that the emissions originate from mixed halide-to-ligand (XLCT approximately 70%) and metal-to-ligand (MLCT approximately 30%) transitions instead of the typical MLCT transition. Using complexes 4 and 5 as the dopant emitters, we evaluated their potential to serve as a phosphor for organic light emitting diodes by examining their electroluminescent performances. Reddish orange electroluminescence centered around 600 nm was observed for organic light emitting diodes (OLEDs) fabricated using complex 5 as the emitter; the device efficiency was shown to be as high as 2.8% (and 5.0 cd/A or 2.7 lm/W), and the peak luminance was shown to be 5600 cd/m(2) at a driving voltage of approximately 15 V.
Data from Antitumor Activity of Targeting Src Kinases in Endothelial and Myeloid Cell Compartments of the Tumor Microenvironment (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Several Src family kinase (SFK) inhibitors have entered clinical trials based on their direct effects against tumor cells. Here, we characterize the effects of targeting Src kinases on the tumor microenvironment and how these effects influence tumor growth.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Human cancer cells grown in cell culture or in mice were treated with dasatinib, a small-molecule inhibitor of SFKs. Tumor cell, endothelial cell, and myeloid cell compartments within the tumor microenvironment were analyzed. Primary human endothelial cells and freshly isolated CD11b+/CD11c− myeloid cells from mice were treated with dasatinib in cell culture. Cellular functions and signaling pathways affected by dasatinib were evaluated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Dasatinib was not cytotoxic in cell culture against the human cancer cell lines investigated here. However, dasatinib administration in human tumor–bearing mice suppressed tumor growth associated with increased tumor cell apoptosis, decreased microvessel density, and reduced intratumoral CD11b+ myeloid cells. Dasatinib directly inhibited motility and other functions of endothelial and myeloid cells, accompanied by the inhibition of phosphorylation of SFKs and downstream signaling. Tumor-infiltrating myeloid cells were identified as the major source of matrix metalloproteinase (MMP)-9 in the tumor microenvironment. Dasatinib treatment reduced MMP-9 levels in the tumor microenvironment through the simultaneous inhibition of recruitment of MMP9+ myeloid cells and MMP-9 gene expression in tumor-infiltrating myeloid cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These findings suggest that Src kinase inhibitors such as dasatinib possess a previously unrecognized anticancer mechanism of action by targeting both host-derived endothelial and myeloid cell compartments within the tumor microenvironment. Clin Cancer Res; 16(3); 924–35&lt;/p&gt;&lt;/div&gt;
Synthesis and Antitumor Properties of Some Neutral Triesters of 5-Fluoro-2'-deoxyuridine-5'-monophosphate and 3',5'-Cyclic Monophosphate (1995)

Abstract Several new prodrugs of 5-fluoro-2′-deoxyuridine 5′-monophosphate and 3′,5′-cyclic monophosphate were synthesized and their antitumor activities were evaluated in vitro.
Polarization Reversal in Ferroelectric KNO3 (1967)

Ferroelectric potassium nitrate has been found, by a pulse-testing technique, to show a threshold electric field, essentially invariant with duration, below which KNO3 behaves as a completely elastic dielectric. Test results on several ferroelectric materials, all single crystals, are shown and compared to the results obtained from fused layers of KNO3. The technique for the detection of a threshold is described and the test circuit for obtaining the required data on change in charge vs applied step voltage is included. Finally, a precise time-independent description of KNO3 polarization reversal over the entire range of applied step fields is given by two empirically derived equations, each covering one side of threshold.