gebhart/patrepeval huggingface dataset:
One-Shot Tagging During Wake and Cueing During Sleep With Spatiotemporal Patterns of Transcranial Electrical Stimulation Can Boost Long-Term Metamemory of Individual Episodes in Humans (2020)

Targeted memory reactivation (TMR) during slow-wave oscillations (SWOs) in sleep has been demonstrated with sensory cues to achieve about 5-12% improvement in post-nap memory performance on simple laboratory tasks. But prior work has not yet addressed the one-shot aspect of episodic memory acquisition, or dealt with the presence of interference from ambient environmental cues in real-world settings. Further, TMR with sensory cues may not be scalable to the multitude of experiences over one's lifetime. We designed a novel non-invasive non-sensory paradigm that tags one-shot experiences of minute-long naturalistic episodes in immersive virtual reality (VR) with unique spatiotemporal amplitude-modulated patterns (STAMPs) of transcranial electrical stimulation (tES). In particular, we demonstrated that these STAMPs can be re-applied as brief pulses during SWOs in sleep to achieve about 10-20% improvement in the metamemory of targeted episodes compared to the control episodes at 48 hours after initial viewing. We found that STAMPs can not only facilitate but also impair metamemory for the targeted episodes based on an interaction between pre-sleep metamemory and the number of STAMP applications during sleep. Overnight metamemory improvements were mediated by spectral power increases following the offset of STAMPs in the slow-spindle band (8-12 Hz) for left temporal areas in the scalp electroencephalography (EEG) during sleep. These results prescribe an optimal strategy to leverage STAMPs for boosting metamemory and suggest that real-world episodic memories can be modulated in a targeted manner even with coarser, non-invasive spatiotemporal stimulation.
Functional and Structural Properties of a Novel Protein and Virulence Factor (Protein sHIP) in Streptococcus pyogenes (2014)

Streptococcus pyogenes is a significant bacterial pathogen in the human population. The importance of virulence factors for the survival and colonization of S. pyogenes is well established, and many of these factors are exposed to the extracellular environment, enabling bacterial interactions with the host. In the present study, we quantitatively analyzed and compared S. pyogenes proteins in the growth medium of a strain that is virulent to mice with a non-virulent strain. Particularly, one of these proteins was present at significantly higher levels in stationary growth medium from the virulent strain. We determined the three-dimensional structure of the protein that showed a unique tetrameric organization composed of four helix-loop-helix motifs. Affinity pull-down mass spectrometry analysis in human plasma demonstrated that the protein interacts with histidine-rich glycoprotein (HRG), and the name sHIP (streptococcal histidine-rich glycoprotein-interacting protein) is therefore proposed. HRG has antibacterial activity, and when challenged by HRG, sHIP was found to rescue S. pyogenes bacteria. This and the finding that patients with invasive S. pyogenes infection respond with antibody production against sHIP suggest a role for the protein in S. pyogenes pathogenesis.
Microvascular Hepatic Artery Anastomosis in Pediatric Living Donor Liver Transplantation: 73 Consecutive Cases Performed by a Single Surgeon (2018)

Therapeutic, IV.
Paper-Based Analytical Device for the On-Site Detection of Nerve Agents (2021)

We report a colorimetric paper-based microfluidic device based on an enzyme inhibition assay that allows the on-site detection of nerve agents by sampling and wicking. The sample and reagents are automatically transported through the channel where an enzyme inhibition reaction is conducted, followed by an enzyme-substrate reaction and a color reaction. This device can detect 0.1 μg/mL of the nerve agent VX in a 2.5 μL drop and is nerve agent selective and robust against temperature, pH, and several liquids. We confirmed that sampling procedures (dilution and wiping) are applicable to this device. Furthermore, the fabrication procedure is easy, and the cost is at most a few tens of cents. Thus, the present device provides a practical method for the urgent detection of nerve agents in suspected chemical terrorism incidents.
Sorption equilibrium isotherms for volatile organics in aqueous solution. Comparison of head-space gas chromatography and on-line UV stirred cell results (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSorption equilibrium isotherms for volatile organics in aqueous solution. Comparison of head-space gas chromatography and on-line UV stirred cell resultsEdward J. Simpson, Ramzi K. Abukhadra, William J. Koros, and Robert S. SchechterCite this: Ind. Eng. Chem. Res. 1993, 32, 10, 2269–2276Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://doi.org/10.1021/ie00022a011Request reuse permissionsArticle Views197Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (985 KB) Get e-Alertsclose Get e-Alerts
The Inclusion Illusion: How children with special educational needs experience mainstream schools (2022)

Inclusion conjures images of children with special educational needs and disabilities (SEND) learning in classes alongside peers in a mainstream school. For pupils in the UK with high-level SEND, who have an Education, Health and Care Plan (formerly a Statement), this implies an everyday educational experience similar to that of their typically-developing classmates. Yet in vital respects, they are worlds apart. Based on the UK’s largest observation study of pupils with high-level SEND, The Inclusion Illusion exposes how attendance at a mainstream school is no guarantee of receiving a mainstream education. Observations of nearly 1,500 lessons in English schools show that their everyday experience of school is characterised by separation and segregation. Furthermore, interviews with nearly 500 pupils, parents and school staff reveal the effect of this marginalisation on the quality of their education. The way schools are organised and how classrooms are composed creates a form of ‘structural exclusion’ that preserves mainstream education for typically-developing pupils and justifies a diluted pedagogical offer for pupils with high-level SEND. Policymakers, not mainstream schools, are indicted over this state of affairs. This book prompts questions about what we think inclusion is and what it looks like. Ultimately, it suggests why a more authentic form of inclusion is needed, and how it might be achieved.
Solvatochromism and acidochromism of azobenzene-functionalized poly(vinyl amines) (2012)

Nucleophilic substitution of fluoroaromatics with poly(vinyl amine) (PVAm) is a suitable method for producing various azobenzene-functionalized PVAms. The solubility of the fluoroaromatic reagents in water was mediated by complexation with 2,6-O-dimethyl-β-cyclodextrin (DMCD). The degree of functionalization has been determined using model compounds as reference system. The solvatochromic properties of the polymers and the model compounds have been studied and interpreted using the well-established linear solvation energy relationships (LSER) of Kamlet–Taft and Catalán. The most dominant effect on the solvatochromic behavior is caused by interactions with solvents of a different dipolarity/polarizability. Also the basicity of the solvents is assumed to play an important role in the solvatochromism of the azobenzene-functionalized PVAms which shows the influence of the polymer chains. Furthermore, the UV/vis absorption spectra show a bathochromic shift with increasing acid strength of the medium. The impact of the PVAm backbone on the color of the chromophore bonded is highlighted.
Optimal control techniques for active noise suppression (2003)

Active suppression of noise in a bounded enclosure is considered within the framework of optimal control theory. A sinusoidal pressure field due to exterior offending noise sources is assumed to be known in a neighborhood of interior sensors. The pressure field due to interior controlling sources is assumed to be governed by a nonhomogeneous wave equation within the enclosure and by a special boundary condition designed to accommodate frequency-dependent reflection properties of the enclosure boundary. The form of the controlling sources is determined by considering the steady-state behavior of the system, and it is established that the control strategy proposed is stable and asymptotically optimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Hypertension Accelerated Experimental Abdominal Aortic Aneurysm Through Upregulation of Nuclear Factor κB and Ets (2006)

In this study, we focused on the effect of hypertension on the transcription factors nuclear factor kappaB (NFkappaB) and ets in the mechanisms of abdominal aortic aneurysm (AAA), and we investigated how hypertension affects the progression of AAA. AAA was produced by elastase perfusion in hypertensive rats and normotensive rats. The size of AAA rapidly increased in hypertensive rats as compared with normotensive rats. Western blot analysis demonstrated that the expression of matrix metalloproteinase (MMP)-2, -3 , -9, and -12, as well as intercellular adhesion molecule, was increased in hypertensive AAA rats, accompanied by upregulation of NFkappaB and ets. Moreover, in situ zymography showed that the activity of MMPs was increased in the aorta of a hypertensive AAA model as compared with that in a normotensive AAA model. Interestingly, transfection of chimeric decoy oligodeoxynucleotide (ODN) resulted in significant inhibition of aortic dilatation both in normotensive and hypertensive rats at 4 weeks after transfection. Destruction of elastic fibers was also significantly inhibited by transfection of chimeric decoy ODN in both hypertensive rats and normotensive rats. The expression of MMP-2, -3, -9, and -12, as well as intercellular adhesion molecule, was significantly attenuated by the chimeric decoy ODN, accompanied by inhibition of the migration of macrophages. Also, the effect of chimeric decoy ODN was confirmed in an organ culture. The present study demonstrated that hypertension accelerated the progression of experimental AAA through upregulation of NFkappaB and ets. Inhibition of NFkappaB and ets could be a novel therapeutic strategy to treat AAA in hypertensive patients.
Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue (2004)

The helicase fragment of Vasa was purified and its RNA-binding activity was examined by a UV cross-linking assay. The fragment was crystallized in complex with poly(U) RNA (U(10)) and a non-hydrolyzable analogue of ATP. The crystal belonged to space group P2(1), with unit-cell parameters a = 71.06, b = 142.35, c = 130.47 A, beta = 90.86 degrees. The cryocooled crystal diffracted to about 2.2 A using synchrotron radiation from station BL41XU at SPring-8.
Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney. (1995)

We analyzed the developmental regulation and role of the neurotrophins during metanephric kidney morphogenesis. RNase protection assay revealed the presence of nerve growth factor, neurotrophin 3 (NT-3), and brain-derived neurotrophic factor mRNAs and the regulation of their expression during embryonic development of rat metanephros. NT-3 induced differentiation (neurite outgrowth) and survival (inhibition of apoptosis) of the neuronal precursors in cultured nephrogenic mesenchymes and neuronal differentiation in cultured whole kidneys, whereas NT-4/5, brain-derived neurotrophic factor, and nerve growth factor were without effect. The neurotrophins did not trigger tubular differentiation of isolated nephrogenic cells, which underwent apoptosis when cultured with or without the neurotrophins. NT-3 is thus an inducer of differentiation and a survival factor for renal neuronal cells, but none of the neurotrophins is a morphogen in kidney tubule induction.
Hormonal Influence on the Secretory Immune System of the Eye (2018)

This chapter focuses on the secretory immune system of the eye, the processes involved in the endocrine control of mucosal immunity. In the secretory immune system, hormones and neuropeptides influence essentially all parameters of immune activity. Immune differences might hypothetically represent a developmental phenomenon evident in young adults, but not necessarily present at earlier or older ages. The regulatory influence of testosterone on the ocular secretory immune system may be unique to the eye. This hypothesis is based upon the observation that endocrine effects on mucosal immunity tend not to be generalized; instead, specific hormones appear to enhance, curtail, or have no action on certain external sites. The sexual dimorphism in the mucosal immune system of the eye may not be entirely due to the effect of androgens. Treatment with androgens, but not other classes of steroid hormones, reverses the orchiectomy effect and restores the lacrimal gland characteristics of &quot;intact&quot; males.
Sup Figure 3 from Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers (2023)

&lt;p&gt;Sup Figure 3. A 59-year-old male with metastatic colorectal cancer treated with 60mg QOD of MK-2206.&lt;/p&gt;
Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors (2019)

Histone deacetylase 11 (HDAC11) preferentially removes fatty acid residues from lysine side chains in a peptide or protein environment. Here, we report the development and validation of a continuous fluorescence-based activity assay using an internally quenched TNFα-derived peptide derivative as a substrate. The threonine residue in the +1 position was replaced by the quencher amino acid 3'-nitro-l-tyrosine and the fatty acyl moiety substituted by 2-aminobenzoylated 11-aminoundecanoic acid. The resulting peptide substrate enables fluorescence-based direct and continuous readout of HDAC11-mediated amide bond cleavage fully compatible with high-throughput screening formats. The <i>Z</i>'-factor is higher than 0.85 for the 15 μM substrate concentration, and the signal-to-noise ratio exceeds 150 for 384-well plates. In the absence of NAD<sup>+</sup>, this substrate is specific for HDAC11. Reevaluation of inhibitory data using our novel assay revealed limited potency and selectivity of known HDAC inhibitors, including Elevenostat, a putative HDAC11-specific inhibitor.
Plasma Structure of Miniature Ring-Cusp Ion Thruster Discharges (2012)

Previous miniature ion thruster studies have demonstrated impressive performance using ring-cusp discharges. These studies suggest that the magnetic field must be sufficiently strong to increase primary electron confinement times for ionization, but weak enough to allow plasma electrons to escape and maintain the plasma potential necessary for ionization. To investigate these phenomena, an experiment was developed to allow detailed measurements of the internal structure and characteristics of a miniature ring-cusp discharge. These measurements provide spatially resolved values for plasma density, electron temperature, and plasma potential along a meridian plane. The magnetic field configuration is arranged as a quasi-periodic domain in order to generalize the findings to all multipole discharges. The results show that the magnetic field strength drives the plasma structure, and the dependence on discharge power can be removed with proper scaling of the plasma parameters. The stronger magnetic field result...
Supplemental material from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry (2023)

&lt;p&gt;Supplemental material on model generation and data handling&lt;/p&gt;
Near‐Infrared Photoinduced Copper‐Catalyzed Azide‐Alkyne Click Chemistry with a Cyanine Comprising a Barbiturate Group (2019)

Abstract A new near‐infrared (NIR) photosensitization system for the activation of a copper‐catalyzed azide‐alkyne cycloaddition click reaction (CuAAC) is reported. Selected cyanines comprising either a cationic or zwitterionic structural pattern were tested for their photosensitization activity to generate Cu(I) by photoreduction of Cu(II) to trigger CuAAC under NIR light at ambient temperature. The photosensitization system described also facilitates chemical modification of UV‐sensitive materials by CuAAC. Upon exposure to light of wavelength 790 nm under anaerobic conditions, the cyanine with a zwitterionic structure comprising a barbiturate group; that is 5‐(6‐(2‐(3‐ethyl‐1,1‐dimethyl‐1H‐benzo[e]indol‐2(3H)‐ylidene)ethylidene)‐2‐(2‐(3‐ethyl‐1,1‐dimethyl‐1H‐benzo[e]‐indol‐3‐ium‐2‐yl)vinyl)cyclohex‐1‐en‐1‐yl)‐1,3‐dimethyl‐2,6‐dioxo‐1,2,3,6‐tetrahydropyrimidin‐4‐olate in combination with Cu(II)‐N,N,N′,N′′,N′′‐pentamethyldiethylene‐triamine complex, exhibited excellent activity with high yields. The possibility to synthesise different macromolecular structures such as telechelic polymers and block copolymers by NIR‐sensitized CuAAC is demonstrated. The structural and molecular characteristics of the intermediates and final products were evaluated by spectral and chromatographic analyses. This new photochemical reaction opens up new pathways for the macromolecular synthesis of complex macromolecular structures and applications requiring light as an activation tool.
Performance evaluation of a new novel planar interdigital sensors (2010)

A new novel planar interdigital sensor has been fabricated to have better sensing performance. The new sensors were fabricated using latest technology in sensor fabrication. The new sensors have four different layers which consist of conductor 1 for main trace and interdigitated capacitor trace, conductor 2 for thicker pads for series mount of resistor and other connections, dielectric dams for the surface mount resistor and a ground plane. Result from the experiments have shown that new novel sensor have better stability in term of amplitude and phase angle, very small resistive part and better shielding to reduce noise. It is also shown that new sensor has stable sensitivity measurement at different temperature.
Service differentiation using a multi‐level RED mechanism (2002)

Abstract This paper describes a multi‐level active queue management scheme that combines packet classification and random early detection (RED) capabilities to provide differentiated performance characteristics for different classes of service. The proposed RED scheme uses a simple control‐theoretic algorithm to randomly discard packets with a load‐dependent probability when a buffer in a router gets congested. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Assessing the transport properties of organic penetrants in low‐density polyethylene using free volume models (2007)

Abstract Three models, two of them relying on free volume—the Cohen–Turnbull–Fujita (CTF) model and the Vrentas–Duda (VD) model, and the third being empirical using an exponential concentration dependence of the diffusivity, were applied to desorption data for a series of alkane penetrants (2,2‐dimethylbutane, cyclohexane, n ‐hexane, n ‐decane, and n ‐tetradecane) in low‐density polyethylene. The CTF model described the desorption data very well and better than the exponential diffusion law. The VD model with the attractive feature of being based on independently determined parameters was unsuccessful in describing the desorption data. Diffusivity data indicated that the three components outside the crystal core were less accessible to n ‐tetradecane than to the other penetrants. This indication was further substantiated by solubility data. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 723–734, 2007
Myometrial Oxytocin Receptors Levels in the Pregnant Rat Are Higher in Distal than in Proximal Portions of the Horn and Correlate with Disparate Oxytocin Responsive Myometrial Contractility in these Segments (1990)

Distal (D) segments of the pregnant rat uterine horn express myometrial oxytocin receptors (MORs) earlier than proximal (P) segments (day 18 vs. 20, respectively); the levels in D segments remain higher than in P segments throughout days 21-22 and correlate with the segment-specific myometrial sensitivity to oxytocin. While progesterone (P4) had no effect on MOR levels, RU486 increased (t1/2 6-12 h) MOR levels both in D and P segments, particularly in days 12-17, and the levels in the P segment equaled those in the D segment. Estradiol had no effect on MOR levels in days 20-22; in days 16-19 estradiol increased MOR levels particularly in the P segment, and the levels in the latter were higher than in the D segment. Capillary plasma P4 levels were higher in P vs. in D myometrial segments. These results indicate, in the pregnant rat, a local uterine control of D greater than P MOR expression by P4 withdrawal beginning in day 18. We hypothesize that the D greater than P MOR expression determines a role for oxytocin in initiating myometrial contractions in the D segment, while in active labor another class of agent(s) assume that function in more proximal segments.
Nitroacetylenes: synthesis of 1-nitro-2-(trialkylsilyl)acetylenes via nitrodesilylation of bis(trialkylsilyl)acetylenes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitroacetylenes: synthesis of 1-nitro-2-(trialkylsilyl)acetylenes via nitrodesilylation of bis(trialkylsilyl)acetylenesRobert J. Schmitt, Jeffery C. Bottaro, Clifford D. Bedford, and Malhotra RipudamanCite this: J. Org. Chem. 1987, 52, 11, 2294–2297Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jo00387a034https://doi.org/10.1021/jo00387a034research-articleACS PublicationsRequest reuse permissionsArticle Views587Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts