gebhart/patrepeval huggingface dataset:
Consensus Recommendations for Optimizing Electronic Health Records for Nutrition Care (2019)

Provision of nutrition care is vital to the health and well-being of any patient who enters the health care system, whether in the ambulatory, inpatient, or long-term care setting. Interdisciplinary professionals-nurses, physicians, advanced practice providers, pharmacists, and dietitians-identify and treat nutrition problems or clinical conditions in each of these health care settings. The documentation of nutrition care in a structured format from screening and assessment to discharge allows communication of the nutrition treatment plans. The goal of this document is to provide recommendations to clinicians for working with an organization's Information Systems department to create tools for documentation of nutrition care in the electronic health record. These recommendations can also serve as guidance for health care organizations choosing and implementing health care software.
Simplify Your Covariance Matrix Adaptation Evolution Strategy (2017)

The standard covariance matrix adaptation evolution strategy (CMA-ES) comprises two evolution paths, one for the learning of the mutation strength and one for the rank-1 update of the covariance matrix. In this paper, it is shown that one can approximately transform this algorithm in such a manner that one of the evolution paths and the covariance matrix itself disappear. That is, the covariance update and the covariance matrix square root operations are no longer needed in this novel so-called matrix adaptation (MA) ES. The MA-ES performs nearly as well as the original CMA-ES. This is shown by empirical investigations considering the evolution dynamics and the empirical expected runtime on a set of standard test functions. Furthermore, it is shown that the MA-ES can be used as a search engine in a bi-population (BiPop) ES. The resulting BiPop-MA-ES is benchmarked using the BBOB comparing continuous optimizers (COCO) framework and compared with the performance of the CMA-ES-v3.61 production code. It is shown that this new BiPop-MA-ES-while algorithmically simpler-performs nearly equally well as the CMA-ES-v3.61 code.
Combined helium I/helium II photoelectron spectroscopic and Hartree-Fock-Slater investigation of electronic structure and bonding in uranium hexamethoxide (1986)

The electronic structure of the uranium(VI) alkoxide U(OCH3)6 has been investigated by using a combination of He I/He II photoelectron spectroscopy and discrete variational (DV) X.alpha. molecular orbital calculations. Good agreement is obtained between the experimental and calculated ionization energies. It is found that the low ionization energy features of the photoelectron spectra are due to varying degrees of donation of the oxygen lone pairs to the empty orbitals on the uranium atom and to the reduction of the molecular symmetry to Ci via bending of the U-O-C linkages. The methyl groups act as both sigma and pi donors to the oxygen 2p orbitals, increasing the overall donor strength of the alkoxide ligands
Acquisition-based capacity estimates for CDMA with imperfect power control (2002)

One of the major advantages of a code division multiple access (CDMA) system is the flexibility in frequency assignment, which allows all the users to share the same frequency band and, possibly, to partially overlay the spectrum allocation of different services. However, before synchronism to the desired sequence is achieved, the presence of multiple access interference (MAI) is a major impairment which determines the performance of the code acquisition sub-system. It has been argued that the acquisition performance in the presence of MAI may pose limits to the capacity of a CDMA system which are more stringent than those coming from bit error probability specifications. We introduce a general definition for acquisition-based capacity of a CDMA system. This quantity is evaluated for an acquisition sub-system with non-coherent correlator/detector and straight serial search in the time uncertainty region. The effect of imperfect power control is also analysed, showing that the capacity may be substantially decreased when the residual standard deviation of the received power level is above 1 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dermatophyte identification in skin and hair samples using a simple and reliable nested polymerase chain reaction assay (2012)

Although the gold standard dermatophyte identification from clinical samples remains fungal cultures, the assay developed in the present study is especially suitable for tinea capitis. Improved sensitivity for the identification of dermatophyte species was obtained as it is possible to identify the dermatophyte when the fungus fails to grow in cultures.
O2‐09‐06: History of Vascular Disease and Risk of Dementia in the Oldest‐Old: The 90+ Study (2016)

Vascular diseases in midlife are commonly associated with an increased risk of dementia later in life. In contrast, we found that history of hypertension in the oldest-old was associated with a decreased risk of dementia. Whether this protective association is unique to hypertension or if other vascular diseases have a similar effect is unknown. Here we analyze common vascular diseases in relation to all-cause dementia risk in a cohort of oldest-old (90 years and older) participants. Participants are from The 90+ Study, an ongoing population-based longitudinal study of people aged 90 and older. At baseline, self-reported history of vascular diseases was obtained from 559 participants without dementia (DSM-IV). Participants were followed every 6 months for up to 10 years (average=2.8 years) with dementia ascertained at each visit. We used Cox regression to estimate risk of dementia in relation to vascular diseases, using age as the time scale, dementia diagnosis as the outcome, and adjusting for gender and education. At baseline, participants were on average 93 years old (range: 90-103) and most were women (71%). During follow-up, 224 (40%) participants developed dementia. The prevalence of vascular disease ranged from 6% for diabetes to 58% for hypertension. Congestive heart failure, heart valve disease, and stroke were significantly associated with an increased dementia risk. In contrast, hypertension was associated with a decreased dementia risk. When the four significant conditions were analyzed simultaneously, estimates were similar and three of the four diseases remained significantly associated with dementia, suggesting these conditions relate to dementia independently of each other.
A new dawn for monoclonal antibodies against antimicrobial resistant bacteria (2022)

Antimicrobial resistance (AMR) is a quickly advancing threat for human health worldwide and almost 5 million deaths are already attributable to this phenomenon every year. Since antibiotics are failing to treat AMR-bacteria, new tools are needed, and human monoclonal antibodies (mAbs) can fill this role. In almost 50 years since the introduction of the first technology that led to mAb discovery, enormous leaps forward have been made to identify and develop extremely potent human mAbs. While their usefulness has been extensively proved against viral pathogens, human mAbs have yet to find their space in treating and preventing infections from AMR-bacteria and fully conquer the field of infectious diseases. The novel and most innovative technologies herein reviewed can support this goal and add powerful tools in the arsenal of weapons against AMR.
Monocytic Differentiation of Acute Promyelocytic Leukemia Cells in Response to 1,25-Dihydroxyvitamin D3 Is Independent of Nuclear Receptor Binding (1995)

We have shown that 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) primes NB4 cells, the only available acute promyelocytic leukemia cell line, for 12-O-tetradecanoyl-phorbol-13-acetate-induced monocytic differentiation. Here, we have used isomers of 1,25(OH)2D3 to investigate the role of 1,25(OH)2D3 and its putative nuclear receptor (VDR) in NB4 cell monocytic differentiation. 1 beta,25-dihydroxyvitamin D3 (HL), a specific antagonist of only the nongenomic signals of 1,25(OH)2D3, attenuated the priming effect of 1,25(OH)2D3. The 6-cis conformer of 1,25(OH)2D3 (HF), which is unable to bind to VDR, was 20 times more potent than 1,25(OH)2D3 as a priming agent for monocytic differentiation. This response was also blocked by the HL antagonist. Unlike myelocytic HL-60 cells, which respond to 1,25(OH)2D3 with increases in VDR expression and monocytic differentiation, neither HF nor 1,25(OH)2D3 regulated VDR expression in NB4 cells. In the monocytic differentiation of acute promyelocytic leukemia cells, 1,25(OH)2D3 appears to signal through a pathway independent of VDR/VDRE action.
Identification of three in vivo phosphorylation sites on the glycogen‐binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline (1990)

The in vivo phosphorylation stoichiometries of 4 serines on the glycogen-binding (G)-subunit of protein phosphatase 1 (PP1) have been determined. In fed rabbits injected with propranolol stoichiometries (mol/mol) were: site 1 (0.67 +/- 0.09), site 2 (0.20 +/- 0.07), site 3a (0.23 +/- 0.01) and site 3b (0). After injection with adrenalin they became: site 1 (0.90 +/- 0.02), site 2 (0.72 +/- 0.01), site 3a (0.23 +/- 0.02) and site 3b (0). These results, together with other data, establish that site 2 phosphorylation by cyclic AMP-dependent protein kinase triggers dissociation of PP1 from the G-subunit in vivo. They also demonstrate that a residue phosphorylated in vitro by glycogen synthase kinase 3 (site 3a) is phosphorylated in vivo.
Multiparametric Magnetic Resonance Imaging and Image-Guided Biopsy to Detect Seminal Vesicle Invasion by Prostate Cancer (2014)

As this technology becomes more available, MP-MRI and MRI/US fusion-guided biopsy may play a role in the preoperative staging for PCa. Future work will determine if improved preoperative staging leads to better surgical outcomes.
Cavity Resonator Integrated Filter (CRIGF) Based External Cavity Laser in a Butterfly Package (2019)

Cavity Resonator Grating Filters are narrowband reflective spectral filters that exhibit high efficiency and high angular acceptance, with large optical alignment tolerances. We show that an external cavity diode laser setup with single mode emission can be integrated in a medium size butterfly package using these filters.
Secrecy Sum-Rates for Multi-User MIMO Regularized Channel Inversion Precoding (2012)

In this paper, we propose a linear precoder for the downlink of a multi-user MIMO system with multiple users that potentially act as eavesdroppers. The proposed precoder is based on regularized channel inversion (RCI) with a regularization parameter α and power allocation vector chosen in such a way that the achievable secrecy sum-rate is maximized. We consider the worst-case scenario for the multi-user MIMO system, where the transmitter assumes users cooperate to eavesdrop on other users. We derive the achievable secrecy sum-rate and obtain the closed-form expression for the optimal regularization parameter α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LS</sub> of the precoder using large-system analysis. We show that the RCI precoder with α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LS</sub> outperforms several other linear precoding schemes, and it achieves a secrecy sum-rate that has same scaling factor as the sum-rate achieved by the optimum RCI precoder without secrecy requirements. We propose a power allocation algorithm to maximize the secrecy sum-rate for fixed α. We then extend our algorithm to maximize the secrecy sum-rate by jointly optimizing α and the power allocation vector. The jointly optimized precoder outperforms RCI with α <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LS</sub> and equal power allocation by up to 20 percent at practical values of the signal-to-noise ratio and for 4 users and 4 transmit antennas.
A 32b microprocessor with on-chip 2Kbyte instruction cache (1987)

A Reduced Instruction Set Computer with a 5-stage pipeline implemented with 150K transistors on an 8mm×8.5mm chip in a 2μm, 2 layer metal CMOS process, will be reported. At operational frequency of 20MHz, a 12MIPS performance has been achieved.
Poly(vinyldibenzothiophenesulfone): Its Redox Capability at Very Negative Potential Toward an All‐Organic Rechargeable Device with High‐Energy Density (2018)

Abstract Dibenzothiophenesulfone undergoes a two‐electron reduction in a single step at a very negative potential of −1.8 V (versus Ag/AgCl) in organic electrolytes, due to the electron‐withdrawing sulfone group and the stability of the resulting dianion. The heterogeneous electron‐transfer rate constant for the reduction is approximately 10 −1 cm s −1 , which is significantly faster than most redox‐active species. The results presented herein suggest that dibenzothiophenesulfone is a potential candidate for use as an anode‐active material with high‐energy density. In addition, radical polymerization of vinyldibenzothiophenesulfone yielded poly(vinyldibenzothiophenesulfone) with a high molecular weight. A rechargeable device is fabricated with only organic compounds; poly(vinyldibenzothiophenesulfone) as the anode, 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)‐substituted poly(methacrylate) as the cathode, and tetraethylammonium salt and organic solvent as the electrolyte. This device yields a maximum output voltage of 2.6 V in these organic devices, and the active component of the anode displays a very high‐energy density of &gt;500 mWh g −1 .
Dynamics-aware numerical coarsening for fabrication design (2017)

The realistic simulation of highly-dynamic elastic objects is important for a broad range of applications in computer graphics, engineering and computational fabrication. However, whether simulating flipping toys, jumping robots, prosthetics or quickly moving creatures, performing such simulations in the presence of contact, impact and friction is both time consuming and inaccurate. In this paper we present Dynamics-Aware Coarsening (DAC) and the Boundary Balanced Impact (BBI) model which allow for the accurate simulation of dynamic, elastic objects undergoing both large scale deformation and frictional contact, at rates up to 79 times faster than state-of-the-art methods. DAC and BBI produce simulations that are accurate and fast enough to be used (for the first time) for the computational design of 3D-printable compliant dynamic mechanisms. Thus we demonstrate the efficacy of DAC and BBI by designing and fabricating mechanisms which flip, throw and jump over and onto obstacles as requested.
Historical Review Of Mongolia And Republic Of Korea'S Relationships At Contemporary Stage (2020)

The article is devoted to a historiographical review of studies on the relations of Mongolia and the Republic of Korea at present. The article presents a number of publications existing now in the scientific literature on the topic under study in Russian, Mongolian, South Korean historiography, as well as some works done by scientists from Western Europe, China, Japan, and the United States. The presented review does not claim to be an exhaustive coverage of all works published under this topic. In this paper, the author tried to show the main problems that are under the attention of Russian and foreign researchers on the issues of collaboration between Mongolia and the Republic of Korea in modern international relations. The paper introduces some significant works (the author's opinion), which have been published over the past 30 years, covering the main issues of bilateral relations. The author concludes that the problem of Mongolian-Korean relations has not yet studied sufficiently. In modern historiography, Mongolian-South Korean relations are not one of the most prospective areas among Russian scientists. They are mainly considered in the link of collaboration development between Mongolia and other countries of North-East Asia. Therefore, the study of Mongolian-South Korean relations requires further special scientific view and development.
Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor α mRNA (1999)

In monocyte/macrophages, the translation of tumor necrosis factor alpha (TNF-alpha) mRNA is tightly regulated. In unstimulated cells, translation of TNF-alpha mRNA is blocked. Upon stimulation with lipopolysaccharides, this repression is overcome, and the mRNA becomes efficiently translated. The key element in this regulation is the AU-rich element (ARE). We have previously reported the binding of two cytosolic protein complexes to the TNF-alpha mRNA ARE. One of these complexes (complex 1) forms with extracts of both unstimulated and lipopolysaccharide-stimulated macrophages and requires a large fragment of the ARE containing clustered AUUUA pentamers. The other complex (complex 2) is only detected after cell activation, binds to a minimal UUAUUUAUU nonamer, and is composed of a 55-kDa protein. Here, we report the identification of the RNA-binding protein TIAR as a protein involved in complex 1. The RNA sequence bound by TIAR and the cytoplasmic localization of this protein in macrophages argue for an involvement of TIAR in TNF mRNA posttranscriptional regulation.
Predicting Anthracycline‐induced Cardiotoxicity in Children – Genome‐Wide Association Study (2013)

Identified genetic markers for anthracycline‐induced cardiotoxicity (ACT) explain only a small fraction of the variability of this phenotype, suggesting the presence of other, as‐of‐yet unidentified susceptibility loci. Therefore, our goal is to identify additional genetic markers with large effect size via genome‐wide association study (GWAS). Patients were recruited and clinically characterized (age at start of treatment, cumulative dose, gender, anthracycline and tumor type, radiation therapy involving the heart, follow‐up time and assessment of LV dysfunction) via the Canadian Pharmacogenomics Network for Drug Safety. We have recruited and clinically characterized over 400 patients from across Canada to serve as our discovery cohort and over 120 patients from the Emma Children's Hospital in Amsterdam, the Netherlands, to be used as our replication cohort. More patients are currently being recruited and the clinical characterization is ongoing. We are now genotyping samples with an Illumina GWAS panel and the statistical analyses will be underway soon using SVS/Helix Tree, SPSS, Epi Info, PLINK and R. Novel genetic predictors for ACT may become essential for screening patients before the start of treatment, comprehensive risk assessment and management, and evidence‐based treatment decisions, monitoring and prevention. This work was supported by CIHR, CFRI, and Genome BC.
Testosterone replacement therapy does not promote priapism in hypogonadal men with sickle cell disease: 12‐month safety report (2013)

Hypogonadism, which is highly prevalent in men with sickle cell disease (SCD), affects quality of life and causes great morbidity. The safety of testosterone replacement therapy (TRT) in SCD in relation to priapism episodes is relatively unknown. Our aim was to monitor the safety of TRT in a cohort of seven hypogonadal men with SCD. Testosterone undecanoate (Nebido) 1 g was administered intramuscularly to adult men with homozygous SCD (Hb SS) having hypogonadism [serum total testosterone ≤12.0 nmol/L (346 ng/dL), reference range 12.5-38.1 nmol/L (360-1098 ng/dL)] for 12 months. Serum total testosterone, haemoglobin, haematocrit, renal and liver function tests, glucose and PSA measurements were done at baseline and 12-month follow-up. Trough serum total testosterone, haemoglobin and haematocrit were measured three monthly. Priapism events and adverse drug events were assessed every 3 months. International Index of Erectile Function (IIEF), Androgen Deficiency in the Ageing Male (ADAM) and World Health Organization Quality of Life (WHOQOL) questionnaires were administered at baseline, 6 and 12 months. Seven men with a mean age of 34.4 years were treated. Median total testosterone increased from 10.6 to 11.2 nmol/L (p = 0.46). Median serum lactate dehydrogenase levels decreased from 1445 to 1143.5 IU/L (p < 0.05), while all other laboratory indices remained stable. Injection site pain was the most frequently reported adverse event, with no increases in painful crises, hypersensitivity or oedema. After TRT, there was no significant increase in priapism frequency. Median questionnaire scores were increased for the IIEF (46-68, p = 0.018), reduced for ADAM (5.0-2.0, p = 0.016) and unchanged for WHOQOL (98-103, p = 0.086). TRT using testosterone undecanoate with eugonadal intent for hypogonadism appears to be safe in men with SCD. This treatment does not appear to promote priapism occurrences and rather it possibly improves sexual function. Future prospective evaluations in larger groups of hypogonadal men with SCD are necessary to confirm these findings.
Confinement of [(H2O)2∩([18]Crown-6)] in a Disc-Shaped Cavity Lined with Six Nickel(II) Macrocycle Dimers Acting as Divergent Receptor Molecules (2000)

Fifteen components build a supermolecule, comprised of two water molecules binding [18]crown-6 and this is itself enclosed by six saddle-shaped [Ni(tmtaa)]2 macrocycles (see picture). The supermolecule interlocks into a two-dimensional layer. An analogous, metal-free supermolecule affords a layered structure consisting of (H2TMTAA)2 dimers separated by layers of [18]crown-6.
Thermal experimental and modeling analysis of high power 3D packages (2015)

In this paper, we present the experimental and modeling characterization of 3D packages for high power applications using a dedicated stackable test chip. An advanced CMOS test chip with programmable power distribution and a 32×32 array of temperature sensors has been designed, fabricated, stacked and packaged in bare die 3D packages. The package thermal measurements have been used to characterize the thermal behavior and to successfully validate the thermal finite element modeling results.
A 50GB/S 1.6PJ/B RX Data-Path with Quarter-Rate 3-Tap Speculative DFE (2018)

A decision feedback equalization (DFE) technique suitable for high data-rate I/O link receivers is presented. The technique leverages quarter-rate data slicing to implement a fully speculative 3-tap DFE and uses clock forwarding to reach a speed of 50Gb/s. It corresponds to 20ps timing closure of the most critical path, which is the feedback of the first DFE tap. The RX data-path is implemented in 14nm FinFET CMOS SOI technology. At 0.9V supply the energy-efficiency is 1.6pJ/b when PRBS15 data transmitted at 50Gb/s across a channel with 32.5dB insertion loss are recovered with >30% horizontal margin (BER<;10- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> ).
Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics (2019)

In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.