gebhart/patrepeval huggingface dataset:
Modeling of Sound Transmission Through Shell Structures With Turbulent Boundary Layer Excitation (1996)

This paper is to develop an analytical model of sound transmission through a simple unstiffened cylindrical aluminum shell excited by a TBL pressure field based on the Corcos formulation for the cross-spectral density (CSD) of the pressure fluctuations. The coupled shell and interior and exterior acoustic equations are solved for the structural displacement and the interior acoustic response using a Galerkin approach to obtain analytical solutions. Specifically, this study compares the real part of the normalized CSD of the TBL excitation field, the structural displacement and the interior acoustic field. Further the modal compositions of the structural and cavity response are examined and some inference of the dominant mechanism of noise transmission is made. Result indicates that the CSD of the shell response are generally correlated at low frequency and the envelope of the correlation function decays with an increase of the spatial separation. The decay occurs much more rapidly at higher frequencies. However, the correlation function of the CSD of the cavity response does not decay with an increase of the spatial separation and frequency. With wavenumber filtering, highly excited cavity modes are reduced in number compared with the shell modes. Most of the cavity mode response is forced by the shell modes. However, some low order cavity resonant modes are excited.
A New Marine Interstitial Ciliate from the Northwest Atlantic Coast Tracheloraphis primitarum Sp. N. (Ciliophora, Kinetofragminophora, Karyorelictida, Trachelocercidae) (1994)

ABSTRACT A new species of marine interstitial ciliate, Tracheloraphis primitarum sp. n., is described from intertidal sands (160‐200‐μm medium grain size) along the Northwest Atlantic coast. Living specimens are not transparent under incident light, 0.4‐0.9 mm in length, and are characterized by an elongated body, bulbous anterior and rounded posterior regions. Cytostome is simple without a cleft on the lip. Protargol silver impregnation shows 18‐29 longitudinal kineties. The glabrous zone is very narrow, 6‐7 μm wide, and corresponds to the area occupied by one kinety and two interkinetal spaces. Ten to fifteen kineties terminate against the glabrous zone. Interkinetal extrusomes are present. The nuclear apparatus is a single centrally‐placed nuclear group that consists of three large irregular macronuclei and 2‐3 micronuclei; these are either clustered or encapsulated.
Impaired insulin secretion in a mouse model of ataxia telangiectasia (2007)

Ataxia telangiectasia (A-T) is an autosomal recessive disease caused by mutations in the A-T mutated (ATM) gene. The gene encodes a serine/threonine kinase with important roles in the cellular response to DNA damage, including the activation of cell cycle checkpoints and induction of apoptosis. Although these functions might explain the cancer predisposition of A-T patients, the molecular mechanisms leading to glucose intolerance and diabetes mellitus (DM) are unknown. We have investigated the pathogenesis of DM in a mouse model of A-T. Here we show that young Atm-deficient mice show normal fasting glucose levels and normal insulin sensitivity. However, oral glucose tolerance testing revealed delayed insulin secretion and resulting transient hyperglycemia. Aged Atm-/- mice show a pronounced increase in blood glucose levels and a decrease in insulin and C-peptide levels. Our findings support a role for ATM in metabolic function and point toward impaired insulin secretion as the primary cause of DM in A-T.
Defects in GaN based transistors (2014)

Electrically active defects in AlGaN/GaN high electron mobility transistors (HEMTs) are the source of intense study due to their linkage to the mechanisms for GaN HEMT degradation upon a variety of stress conditions. The ability to directly characterize traps and identify their sources in GaN HEMTs is challenging, however, and this is due to a combination of the large bandgap of these materials and the complex electrostatics present in these device structures. Furthermore, the targeted extreme operating conditions intended for GaN HEMTs, whether designed for RF or power applications, greatly exacerbate the ability to identify those defects that are most relevant to device degradation under actual operation. Over the past few years, however, we have developed several electronic defect characterization methods based on deep level optical spectroscopy (DLOS) and thermally-based deep level transient spectroscopy (DLTS), which have been adapted from basic studies of defects in GaN and AlGaN to become applicable to working HEMTs. These so-called constant drain current (CI<sub>D</sub>) DLOS/DLTS methods are able to directly provide individual trap concentrations and energy levels for traps that may exist throughout the AlGaN/GaN HEMT bandgap, and can discern between traps under the gate or in the transistor access regions. This talk will first review the CI<sub>D</sub>-DLOS/DLTS methodology and then will focus on the application of these methods to stressed and un-stressed AlGaN/GaN HEMTs. Direct correlations of the formation of several specific traps are made with a variety of HEMT degradation mechanisms induced by stresses that include RF, DC and also proton irradiation
A case for in-kernel data streaming over the file subsystem (1998)

(Also cross-referenced as UMIACS-TR-96-36)
Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development (2019)

With appropriate attention to safety and effectiveness, digital health technology could improve screening and treatment of ophthalmic diseases and improve access to care.
Synthesis and Absolute Structure Determination of Camphanoate Derivatives of Five Bicyclo[3.1.0]hexane Compounds (1998)

The relative and absolute stereochemistry of five compounds, ((1R,2S,4R,5S)-exo-2-acetoxy-3,3-dimethylbicyclo[3.1.0]hexan-exo-4-yl) camphanoate, C20H28O6 (I), ((1R,2S,4R,5S,6R)-exo-2-acetoxy-3,3,exo-6-trimethyl­bicyclo[3.1.0] hexan-exo-4-yl) camphanoate, C21H30O6 (II), ((1R,2S,4R,5S,6S)-exo-2-acetoxy-3,3,endo-6-trimethylbicyclo[3.1.0] hexan-exo-4-yl) camphanoate, C21H30O6 (III), ((1S,2S,4R,5R,6S)-exo-2-acetoxy-endo-6-(3-butenyl)-3,3,exo-6- trimethylbicyclo[3.1.0]hexan-exo-4-yl) camphanoate, C25H36O6 (IV), and ((1S,2S,4R,5R,6S)-endo-2-acetoxy-3,3,exo-6-trimethylbicyclo[3.1.0]hexan-endo-4-yl) camphanoate, C21H30O6 (V), (camphanoate is 4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylate) have been determined and the conformation of the five-membered ring of each one is discussed. These compounds were synthesized by an enantioselective esterase-catalyzed hydrolysis followed by acylation with camphanoyl chloride.
Optically Reconfigurable Reflective/Scattering States Enabled with Photosensitive Cholesteric Liquid Crystal Cells (2013)

Circularly polarized light is employed to write information into cholesteric liquid crystal (CLC) cells that initially exhibit homogeneous planar alignment and are fabricated with a photoaligning boundary layer. Overlap of the writing beam with light reflected from the CLC phase disrupts the reflective Grandjean texture, resulting in a localized region that strongly scatters light. These scattering areas can be geometrically patterned using circularly polarized light and a mask, erased and brought back to the original reflective condition by exposure to linearly polarized light, and then repatterned with a different mask using circularly polarized light. The light‐induced scattering is localized to the side of the cell being exposed. Within the scattering region a microscopic texture is formed, which exhibits an average feature, or “domain”, size related to cell thickness and helical pitch. The behavior occurs only when the CLC and incoming writing radiation exhibit the same handedness and when the reflection bandwidth of the CLC is commensurate with the wavelength of the incoming radiation. This new phenomena provides the ability to reconfigure reflectivity from a CLC cell and is expected to be useful for systems where all optical control of dynamic information is needed.
Modeling Ionic Continua Under Multifield Conditions (2006)

Recent advances in the development of electroactive polymer materials and composites along with the need for new multifunctional exploitation of these materials have underlined the need for the multi-field modeling of their behavior. Behavioral modeling of these materials is essential for design, material qualification, and material certification for sensing, actuation, and energy harvesting applications. The present paper proposes and applies a methodology for modeling the behavior of ionic continua under multi-field influence at the macro length scale. The computational implementation of this methodology addresses generation and solution of both the constitutive and the field evolution equations by appropriate use of continuum mechanics, irreversible thermodynamics, and electrodynamics. An application of this methodology for the case of electric multi-component anisotropic hygrothermoelasticity generates a constitutive model for a large class of materials capable of actuation, sensing, and energy harvesting applications. A specialization of this theory for isotropic and bi-component chemo-thermo-electro-elastic materials is provided along with the corresponding field equations. To demonstrate the capabilities of this approach for realistic applications, a system of nonlinear governing partial differential equations is derived to describe the state evolution of large deflection plates made from such material systems. These equations represent the electro-hygro-thermal generalization of the well-known von-Karman equations for large deflection plates and capture the actuating behavior of these plates. Finally, numerical solutions of these equations for two sets of boundary conditions are presented to demonstrate solution feasibility and realism of modeling in the context of actuation-based applications.
Fluorophore-Induced Plasmonic Current Generation from Aluminum Nanoparticle Films (2023)

In this paper we demonstrate fluorophore induced plasmonic current (FIPC) from aluminum nanoparticle films. It has been previously shown that near-field excited fluorophores are able to plasmonically couple with metal nanoparticle films (MNF's) and induce surface plasmons, which in turn leads to a direct measurable electrical current through the MNF. These currents have been detected and quantified in noble metal MNF's, however due to future envisioned cost considerations there has been a push to adapt FIPC for use with less expensive metals. Subsequently, we observe that plasmonic aluminum films are able to produce these current changes when in close proximity to excited fluorophores, and the magnitude of the current changes are respective to the magnitude of the extinction coefficients of the fluorophores themselves. These findings also further support recent literature reports showing the inverse relationship between metal-enhanced fluorescence (MEF) and FIPC.
<title>Evaluation of a CdZnTe dual-energy system</title> (1997)

The purpose of the study is to optimize the input and the output parameters of a dual energy CdZnTe semiconductor detector for chest radiography. The optimal detector parameters were obtained by maximizing the figure of merit, defined as the ratio between the square of the signal-to- noise ratio and the absorbed dose, for chest radiography.
Real-Time Measurements for Adaptive and Cognitive Radio Systems (2009)

Adaptive and cognitive radios (CR) have been becoming popular for optimizing mobile radio system transmission and reception. One of the most important elements of the adaptive radio and CR concepts is the ability to measure, sense, learn about, and be aware of parameters related to the radio channel characteristics, availability of spectrum and power, interference and noise temperature, operational environment of radio, user requirements and applications, available networks and infrastructures, local policies, other operating restrictions, and so on. This paper discusses some of the important measurement parameters for enabling adaptive radio and CR systems along with their relationships and impacts on the performance including relevant challenges.
Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans (2004)

The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (HIF). Although studies of VHL-defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysregulation of the HIF transcriptional cascade has extensive effects that make it difficult to distinguish whether, and to what extent, observed abnormalities in these cells represent effects on pathways that are distinct from HIF. Here, we report on a genetic analysis of HIF-dependent and -independent effects of VHL inactivation by studying gene expression patterns in Caenorhabditis elegans. We show tight conservation of the HIF-1/VHL-1/EGL-9 hydroxylase pathway. However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. Genomic clustering, predicted functional similarities, and a common pattern of dysregulation in both vhl-1 worms and a set of mutants (dpy-18, let-268, gon-1, mig-17, and unc-6), with different defects in extracellular matrix formation, suggest that dysregulation of these genes reflects a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function.
Performance of a thermal management system for thermophoresis based soot sensors — Design, performance and verification (2010)

This paper presents the thermal performance of a proposed thermal management device (patented in 2009) intended for a thermophoretic based soot sensor. The performance was studied for temperatures ranging from 50°C to 400°C and for exhaust speeds up to 10m/s. It also presents the design and basic concepts. The performance study and design development was performed with finite element analysis (FEA). The FEA results were then verified with experiments in a heated wind tunnel. The relative performance of the device was found to increase for higher temperatures and lower wind speeds. The main conclusion drawn from this study was that it is feasible to cool a sensor surface enough for a thermophoretic based soot sensor in a diesel exhaust system.
Bilateral Adrenal Hemorrhage (2005)

Total knee arthroplasty is a commonly performed surgical procedure usually associated with excellent improvement in mobility and function and with lessening of pain. Most cases are performed without complication. Complications, when they do occur, are most often associated with deep venous thrombosis and possible pulmonary embolism, infection, prosthetic failure or loosening, or neurovascular complications. This article presents a case report of an unusual, but serious, complication, bilateral adrenal hemorrhage, occurring in the postoperative, rehabilitative phase after what seemed to be successful bilateral knee arthroplasties in an 83-yr-old woman.
Dielectric tensor for magneto-optic NiMnSb (1999)

The diagonal component ${\ensuremath{\varepsilon}}_{\mathrm{xx}}$ and off-diagonal component ${\ensuremath{\varepsilon}}_{\mathrm{xy}}$ of the complex dielectric tensor for the ferromagnetic compound NiMnSb are determined using ex situ spectroscopic ellipsometry and magneto-optic analysis over the spectral range from 0.7 to 6.2 eV. The effects of the overcoat on the raw data are removed by the analysis. First, the complex ${\ensuremath{\varepsilon}}_{\mathrm{xx}}$ of thin-film NiMnSb were determined by ex situ spectroscopic ellipsometry; then ${\ensuremath{\varepsilon}}_{\mathrm{xy}}$ was determined by analyzing Kerr rotation and ellipticity data using the determined ${\ensuremath{\varepsilon}}_{\mathrm{xy}}$ data. Lorentz oscillators were used to model peaks seen in the ${\ensuremath{\varepsilon}}_{\mathrm{xx}}$ spectra. The diagonal dielectric component ${\ensuremath{\varepsilon}}_{\mathrm{xx}}$ is dominated by free-carrier effects below 1.15 eV, and dominated by interband transitions above 2.0 eV. The center energies of the Lorentz oscillators are consistent with the calculated band structure and minority-spin optical conductivity of NiMnSb. Joint density of states and optical conductivity calculated from ${\ensuremath{\varepsilon}}_{\mathrm{xx}}(2)$ data with free-carrier effects removed shows onset energies at \ensuremath{\sim}0.6 and \ensuremath{\sim}0.2 eV, respectively. From a study of the ${\ensuremath{\varepsilon}}_{\mathrm{xx}}$ and ${\ensuremath{\varepsilon}}_{\mathrm{xy}}$ spectra, the Kerr rotation peak at lower energy is determined to be due to combined contributions from: (1) a crossover between the free-carrier effect and interband transitions, and (2) transitions involving spin-orbit coupling. The high-Kerr rotation peaks at higher energies result exclusively from transitions involving spin-orbit coupling.
Data from Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem–Like Cells and Reduces Metastases through Effects on Lipid Anabolism (2023)

&lt;div&gt;Abstract&lt;p&gt;Cancer stem-like cells (CSC) induce aggressive tumor phenotypes such as metastasis formation, which is associated with poor prognosis in triple-negative breast cancer (TNBC). Repurposing of FDA-approved drugs that can eradicate the CSC subcompartment in primary tumors may prevent metastatic disease, thus representing an effective strategy to improve the prognosis of TNBC. Here, we investigated spheroid-forming cells in a metastatic TNBC model. This strategy enabled us to specifically study a population of long-lived tumor cells enriched in CSCs, which show stem-like characteristics and induce metastases. To repurpose FDA-approved drugs potentially toxic for CSCs, we focused on pyrvinium pamoate (PP), an anthelmintic drug with documented anticancer activity in preclinical models. PP induced cytotoxic effects in CSCs and prevented metastasis formation. Mechanistically, the cell killing effects of PP were a result of inhibition of lipid anabolism and, more specifically, the impairment of anabolic flux from glucose to cholesterol and fatty acids. CSCs were strongly dependent upon activation of lipid biosynthetic pathways; activation of these pathways exhibited an unfavorable prognostic value in a cohort of breast cancer patients, where it predicted high probability of metastatic dissemination and tumor relapse. Overall, this work describes a new approach to target aggressive CSCs that may substantially improve clinical outcomes for patients with TNBC, who currently lack effective targeted therapeutic options.&lt;/p&gt;Significance:&lt;p&gt;These findings provide preclinical evidence that a drug repurposing approach to prevent metastatic disease in TNBC exploits lipid anabolism as a metabolic vulnerability against CSCs in primary tumors.&lt;/p&gt;&lt;/div&gt;
Cu/CeO2 and Cu/Gd-Substituted CeO2 Aerogels as Active, Selective, and Stable COPROX Catalysts (2023)

Purifying hydrogen feedstocks necessitates preferential oxidation of carbon monoxide (COPROX), but traditional precious metal catalysts are poorly selective, while transition metal catalysts suffer from insufficient activity and stability. We report that Cu nanoparticles supported on CeO2 or Gd(III)-substituted CeO2 (GCO) aerogels deliver a rare combination of high activity, selectivity, and stability for COPROX. The reducing oxide disperses Cu and stabilizes its more active low-valent state. Aerogel-supported Cu oxidizes CO at low temperature but requires higher temperatures to oxidize H2 and, therefore, shows wide temperature ranges with >95% CO conversion and >95% selectivity vs H2. This performance is maintained for >16 h of continuous operation in dry or humidified reaction streams. The Cu/GCO aerogel is less active than Cu/CeO2 under dry feedstreams but experiences less loss of activity under humid conditions because the higher surface area of the former distributes surface-adsorbed water along the network and reacts it at oxygen vacancies. Aerogel-based architected catalysts offer an effective design route to achieve high and stable catalytic activity under industrially relevant conditions.
Synapsin IIa: expression in insect cells, purification, and characterization (1992)

Synapsin IIa belongs to a family of neuron-specific phosphoproteins called synapsins, which are associated with synaptic vesicles in presynaptic nerve terminals. In order to examine the biochemical properties of synapsin IIa, and ultimately its physiological function, purified protein is required. Since attempts to purify significant quantities of synapsin IIa, an isoform of the synapsins, from mammalian brain have proven difficult, we undertook the production of recombinant synapsin IIa by utilizing the baculovirus expression system. Rat synapsin IIa cDNA was introduced into the baculovirus genome via homologous recombination, and the recombinant baculovirus was purified. Spodoptera frugiperda (Sf9) cells infected with this virus expressed synapsin IIa as 5% of the total cellular protein. The recombinant protein was extracted from the particulate fraction of the infected Sf9 cells with salt and a nonionic detergent and purified by immunoaffinity chromatography. The purified synapsin IIa was phosphorylated by the catalytic subunit of cAMP-dependent protein kinase to a stoichiometry of 0.8 mol of phosphate/mol of protein. Metabolic labeling with [32P]Pi demonstrated synapsin IIa phosphorylation in infected Sf9 cells. Using a homogenate of uninfected Sf9 cells, a cAMP-dependent protein kinase activity which can phosphorylate synapsin IIa was detected. Limited proteolysis of recombinant synapsin IIa phosphorylated in vitro and in vivo resulted in identical phosphopeptide maps. Further, synapsin IIa, like synapsin I, binds with high affinity in a saturable manner to synaptic vesicles purified from rat cortex.
0.13μm CMOS/DMOS platform technology with novel 8V/9V LDMOS for low voltage high-frequency DC-DC converters (2010)

This paper presents a novel low voltage LDMOS structure with low on-resistance based on 0.13μm CMOS technology. 8V/9V Nch LDMOS have only 0.3μm gate length when the maximum gate operating voltage is 5V, while the gate length of 5V CMOS is 0.6μm to avoid the short channel effect. The obtained specific on-resistance are 1.8mΩmm2 (8V Nch LDMOS) and 5.9mΩmm2 (8V Pch LDMOS) respectively. Furthermore ESD protection structure for 8V LDMOS without any additional mask is also fabricated with large second breakdown trigger current It2 in spite of the same device size.
Preconcentration of Cardiac Proteins in a Cascade Microchip (2011)

Concentration of bio-molecules prior to detection is very critical in the development of an integrated, multifunctional lab-on-a chip device for detection of ultra trace molecules from complex biological fluids such as serum, urine, or saliva. In this work, the preconcentration of a clinically relevant biomarker, cardiac troponin I (cTnI), is demonstrated in a cascade microfluidic channel using cationic isotachophoresis (ITP). The cascade chip is formed on PMMA (poly methyl methacrylate) with gradual changes in size both in width and depth direction to achieve a 100× reduction in overall cross sectional area between inlet (anode) and outlet (cathode) sections. The ITP experiments were conducted with two fluorescent proteins, FITC (Fluorescein isothiocyanate-conjugated) albumin and cTnI labeled with Pacific Blue. Potassium ions were used as the leader and hydronium ions were used as the terminator for these cationic ITP experiments. The microchip ITP demonstrates that it is possible to increase the concentration of cTnI by 10,000 folds using a potential drop of 400 V across a 3.5 cm long microchannel. The reduction in cross sectional area facilitates additional concentration gain, as the proteins migrate through cascade microchannel under discontinuous electric field and stacked into nearly pure zones.