gebhart/patrepeval huggingface dataset:
Design and Implementation of Real-time Bio Signals Management System based on HL7 FHIR for Healthcare Services (2021)

Recently, attention has been focused on services that combine medical technology with ICT technologies such as artificial intelligence, big data, Internet of Things, and block chains. In addition, Research on healthcare services that can collect bio signal data through wearable sensors using IoT technology and monitor and manage health based on the collected data is increasing significantly. In particular, in a situation where the world is entering a rapidly aging society, health care services are being researched and developed in the direction of preventing diseases in advance and maintaining a healthy life. Healthcare services are bringing important changes in the pandemic era caused by covid-19. There is a need for a system capable of efficiently sharing and exchanging information of heterogeneous services to prevent emergencies and support optimal medical services. In this paper, we designed and developed a system that can collect, convert, and store bio-signals from various wearable sensors into international standard data to develop such healthcare services. HL7 (health level seven) FHIR (fast healthcare interoperability resources) applied mutandis in this paper is a standard protocol for data exchange between medical information systems of real-time collected bio signals. In this paper, we implement an interface module that converts bio signals such as EEG (electroencephalography), ECG (electrocardiogram), EMG (electromyography), and PPG (photoplethysmography) collected in real time from a wearable sensor into a message structure defined by HL7 FHIR. The interface module consists of a client part and a server part. The client part generates a variety of signal data from the healthcare service user and delivers the message to the server part. The server part is designed and implemented to parse the received message by segment field unit and transmit whether the message is abnormal or not to the client part. The system designed and implemented in this paper will be utilized as a technology that can mutually share and exchange medical information in a customized healthcare service that reflects the needs of various customers and a telemedicine system.
A flow-based model for TCP traffic in an IP backbone network (2002)

We present a model of TCP flows suited to Internet backbone traffic, where links are usually not congested. We characterize the traffic using information on flows, i.e., arrival time, size, and duration. The major contribution of this paper is a model capturing the variation of the transmission rate during a TCP flow solely based on the above flow parameters. This model accounts for the dynamics of TCP congestion window and for the Timeout mechanism. It is independent of the packet loss rate and the round-trip time of the connection. We then model the traffic on a backbone link by aggregating TCP flows. Our model is easy to compute, and we show via simulations that it gives a good approximation of Internet backbone traffic.
ChemInform Abstract: Copper‐Catalyzed Selective Hydroamination Reactions of Alkynes. (2015)

Abstract This is a versatile method for the hydroamination and reductive hydroamination of alkynes yielding enamines and amines respectively.
Supplementary Figure S3. from Efficacy and Determinants of Response to HER Kinase Inhibition in <i>HER2</i>-Mutant Metastatic Breast Cancer (2023)

&lt;p&gt;Comprehensive OncoPrint of nine patients with paired pre- and post-treatment tissue sequencing showing acquired alterations in the post-treatment tumor.&lt;/p&gt;
Table S3 from Functional Silencing of <i>HSD17B2</i> in Prostate Cancer Promotes Disease Progression (2023)

&lt;p&gt;17βHSD2 staining density in patient specimens.&lt;/p&gt;
ATLAS b-jet identification performance and efficiency measurement with $$t{\bar{t}}$$ events in pp collisions at $$\sqrt{s}=13$$ TeV (2019)

Abstract The algorithms used by the ATLAS Collaboration during Run 2 of the Large Hadron Collider to identify jets containing b -hadrons are presented. The performance of the algorithms is evaluated in the simulation and the efficiency with which these algorithms identify jets containing b -hadrons is measured in collision data. The measurement uses a likelihood-based method in a sample highly enriched in $$t{\bar{t}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>t</mml:mi><mml:mover><mml:mrow><mml:mi>t</mml:mi></mml:mrow><mml:mrow><mml:mo>¯</mml:mo></mml:mrow></mml:mover></mml:mrow></mml:math> events. The topology of the $$t \rightarrow W b$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>t</mml:mi><mml:mo>→</mml:mo><mml:mi>W</mml:mi><mml:mi>b</mml:mi></mml:mrow></mml:math> decays is exploited to simultaneously measure both the jet flavour composition of the sample and the efficiency in a transverse momentum range from 20 to 600 GeV. The efficiency measurement is subsequently compared with that predicted by the simulation. The data used in this measurement, corresponding to a total integrated luminosity of 80.5 $$\hbox {fb}^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>fb</mml:mtext><mml:mrow><mml:mo>-</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:math> , were collected in proton–proton collisions during the years 2015–2017 at a centre-of-mass energy $$\sqrt{s}=$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo></mml:mrow></mml:math> 13 TeV. By simultaneously extracting both the efficiency and jet flavour composition, this measurement significantly improves the precision compared to previous results, with uncertainties ranging from 1 to 8% depending on the jet transverse momentum.
Photoemission Study of the Electronic Structure of LaFeAsO1-xFxand LaFePO1-xFx (2008)

We have performed a photoemission spectroscopy study of the newly discovered iron-based superconductors LaFeAsO 1- x F x and LaFePO 1- x F x . The valence-band spectra show a narrow Fe 3 d -derived band near E F indicating the itinerant character of the Fe 3 d states. In going from the undoped to F-doped compounds, all the spectra are found to shift to higher binding energies, consistent with electron doping within the rigid-band model. Also, in going from LaFeAsO 1- x F x to LaFePO 1- x F x , the near- E F intensity increases reflecting the weakening of electron correlation.
Characterization of transmission lines with through-silicon-vias and bump joints on high-resistivity Si interposers for RF three-dimensional modules (2016)

Abstract Microstrip lines and coplanar waveguides (CPWs) for RF three-dimensional (3D) modules were characterized on high-resistivity Si interposers: 2,000 Ω·cm. The diameter and thickness of through-silicon-vias (TSVs) in Si interposers were 50 and 250 µm, respectively. A signal TSV around five ground TSVs, and a signal solder bump around five ground solder bumps were designed to obtain the vertical transitions with low electrical loss between the transmission lines. For the 3D interconnections between Si interposers, a fluxing underfill material was developed and used as a preapplied underfill during the thermocompression bonding. The S -parameters of transmission lines and stacked transmission lines were measured from 0.5 to 10 GHz using a vector network analyzer (VNA) and de-embedded so that their electrical losses were obtained and compared. By comparing with the electrical loss of the transmission line on low-temperature cofired ceramics (LTCC), we found that both transmission lines were sufficiently good for applications in RF 3D modules.
Dual-Mode Chirp Spread Spectrum Modulation (2022)

In this letter, we propose dual-mode chirp spread spectrum (DM-CSS) modulation for low-power wide-area networks. DM-CSS is capable of achieving a higher spectral efficiency (SE) relative to its counterparts, such as Long Range (LoRa) modulation. Considering the same symbol period, the SE in DM-CSS are augmented by: (i) simultaneously multiplexing even and odd chirp signals; (ii) using phase shifts of 0 and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\pi $ </tex-math></inline-formula> radians for both even and odd chirp signals; and (iii) using either up-chirp or down-chirp signal. The SE increases by up to 116.66% for the same bandwidth and spreading factor relative to LoRa. We present a complete transceiver architecture along with non-coherent detection process. Simulation results reveal that DM-CSS is not only more spectral efficient but also more energy efficient than most classical counterparts. It is also demonstrated that DM-CSS is robust to phase and frequency offsets.
PLEOMO RPHIC ADENOMA OF SOFT PALATE: A CASE REPORT (2014)

Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% of them occur in the minor salivary glands. The most common sites for pleomorphic adenoma of the minor salivary glands are the palate, followed by the lips and the cheeks. Other rare sites include the floor of the mouth, tongue, tonsil, pharynx, the retromolar area and the nasal cavity. Here, we are reporting a case of pleomorphic adenoma of the soft palate in a 45 year old Indian female. The mass was removed by wide local excision with adequate margins under GA.
Bioactive Glass as a Bone Substitute for Spinal Fusion in Adolescent Idiopathic Scoliosis (2008)

Level III.
Total Synthesis and Configurational Assignment of (‐)‐Dictyostatin (I), a Microtubule‐Stabilizing Macrolide of Marine Sponge Origin. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Renal system (1998)

Department of Intensive Care Medicine, Austin & Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia.
Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned (2022)

Acute liver failure (ALF) is a rare but devastating disease associated with substantial morbidity and a mortality rate of almost 45%. Medical treatments, apart from supportive care, are limited and liver transplantation may be the only rescue option. Large animal models, which most closely represent human disease, can be logistically and technically cumbersome, expensive and pose ethical challenges. The development of isolated organ perfusion technologies, originally intended for preservation before transplantation, offers a new platform for experimental models of liver disease, such as ALF. In this study, female domestic swine underwent hepatectomy, followed by perfusion of the isolated liver on a normothermic machine perfusion device. Five control livers were perfused for 24 h at 37 °C, while receiving supplemental oxygen and nutrition. Six livers received toxic doses of acetaminophen given over 12 h, titrated to methemoglobin levels. Perfusate was sampled every 4 h for measurement of biochemical markers of injury (e.g., aspartate aminotransferase [AST], alanine aminotransferase [ALT]). Liver biopsies were taken at the beginning, middle, and end of perfusion for histological assessment. Acetaminophen-treated livers received a median dose of 8.93 g (8.21-9.75 g) of acetaminophen, achieving a peak acetaminophen level of 3780 µmol/L (3189-3913 µmol/L). Peak values of ALT (76 vs. 105 U/L; <i>p</i> = 0.429) and AST (3576 vs. 4712 U/L; <i>p</i> = 0.429) were not significantly different between groups. However, by the end of perfusion, histology scores were significantly worse in the acetaminophen treated group (<i>p</i> = 0.016). All acetaminophen treated livers developed significant methemoglobinemia, with a peak methemoglobin level of 19.3%, compared to 2.0% for control livers (<i>p</i> = 0.004). The development of a model of ALF in the ex vivo setting was confounded by the development of toxic methemoglobinemia. Further attempts using alternative agents or dosing strategies may be warranted to explore this setting as a model of liver disease.
Case Studies in Deriving Holistic Insights from an Automated Drilling Optimization Platform (2018)

Abstract The last decade has seen a tremendous increase in the use of oilfield data to understand problems of well construction, evaluate drilling performance and derive guidance on future drilling. Despite the tremendous increase in investment and application of various data mining techniques, the outcomes in the well construction domain have been subpar when compared to that of other industries. Yet analysis of drilling data has resulted in useful predictions on the small scale–comparing a few wells where the huge number of variables that influence drilling (formation, rig, bottomhole assemblies [BHA], etc.) have little fluctuation. However, making actionable predictions on a much greater scale, and in the presence of significant variability, is substantially more challenging. The authors introduce a new platform for automated drilling analysis and optimization. The system starts with an enhanced in-bit measurement device that enables an improved view of downhole conditions at a higher density. This data is then tied to surface measurements through robust data validation and streamlined capture of variables. Finally, the platform ties state-of-the-art, physics-based models, which capture the physics of drilling from cutter-rock interface, to power delivery from the rig through the BHA to quantify the influence of each variable. This coupling of physics-based modeling and models based on drilling data is used to deliver key holistic insights–not just on speed of drilling, but also balance it against borehole quality, efficiency and health of the tools. Results of this new optimization platform, which was tested in the SCOOP and STACK plays of Central Oklahoma, are presented in this paper. The platform shows the power of combining physics and measured data to detect hidden insights, derive actions and enhance drilling performance.
Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue (1999)

Near-infrared (NIR) spectroscopic diffuse tomography has been used to map the hemoglobin concentration and the hemoglobin oxygen saturation quantitatively in tissuelike phantoms and to determine average values in vivo. A series of phantom calibrations were performed to achieve quantitatively accurate images of the absorption and the reduced scattering coefficients at multiple optical wavelengths. A least-squares fit was applied to absorption-coefficient images at multiple NIR wavelengths to obtain hemoglobin images of the concentration and the hemoglobin oxygen saturation. Objects of varying hemoglobin concentration and oxygen saturation within highly scattering media were localized and imaged to within 15% of their actual values. The average hemoglobin concentration and oxygen saturation of breast tissue was measured in vivo for two women volunteers. The potential application for the diagnosis of breast tumors is discussed.
Electrochemical Impedance Spectroscopy at Well‐Controlled dc Bias for Nanoporous Platinum Microelectrodes in Rat Embryo Brain (2016)

Abstract Nanoporous Pt with extremely small (1–2 nm) and uniform nanopores, L 2 ‐ePt, is electrochemically investigated in rat embryo brain. In a comparative study under precise control of electrochemical potential, an electrochemical cell beneath the brain surface is constructed by introducing flat and nanoporous Pt twisted wires around which Ag/AgCl is wound. L 2 ‐ePt and flat Pt in the brain are compared with each other by conventional voltammetry and electrochemical impedance spectroscopy at the dc bias, which is carefully selected to minimize faradaic interference. The electrochemical behavior at L 2 ‐ePt implanted into embryo brain is immune to severe passivation and is closer to an ideal capacitor than flat Pt. A lower electrode impedance of L 2 ‐ePt leads to less potential drop at the interface between the electrode and the extracellular solution, protecting the implanted system from unwanted faradaic reactions. Various aspects, including the low electrode impedance and electrochemical stability in embryo brain, suggest that L 2 ‐ePt is a promising electrode material for effectively stimulating distant neuronal cells and recording local field potential signals.
Detection of Polarized Infrared Emission by Polycyclic Aromatic Hydrocarbons in the MWC 1080 Nebula (2017)

Abstract Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in astrophysical environments, as revealed by their pronounced emission features at 3.3, 6.2, 7.7, 8.6, 11.3, and 12.7 μ m commonly ascribed to the C–H and C–C vibrational modes. Although these features have long been predicted to be polarized, previous searches for PAH polarization led to null or, at best, tentative detections. Here we report the definite detection of polarized PAH emission at 11.3 μ m in the nebula associated with the Herbig Be star MWC 1080. We measure a polarization degree of 1.9% ± 0.2%, which is unexpectedly high compared to models. This poses a challenge in the current understanding of the alignment of PAHs, which is required to polarize the PAH emission but thought to be substantially suppressed. PAH alignment with a magnetic field via a resonance paramagnetic relaxation process may account for such a high level of polarization.
Exploring the Relationships Between Internalised Stigma, Loneliness, and Mental Well-Being Among Sex Workers (2022)

Abstract Sex work is one of the most stigmatised professions in the world. Although research examining other stigmatised populations has found associations between internalised stigma, increased loneliness, and poorer mental well-being, there is limited research examining these associations for sex workers. This is concerning, considering Corrigan’s theory that internalised stigma, as well as external stigma, reduces opportunities of stigmatised persons. Further, internalised stigma, loneliness, and poorer well-being have been associated with significant social, mental, and physical consequences for stigmatised populations. As such, this exploratory study investigated sex workers’ internalised stigma, and its relationship with their mental well-being and experience of loneliness. 56 full-service sex workers (78.6% females, 12.5% non-binary, 8.9% males, ranging from 18 to 43 years old) completed an online, cross-sectional survey measuring their self-reported internalised stigma, loneliness, and mental well-being. Hierarchical multiple regression analyses (MRAs) supported the hypotheses that higher internalised stigma would significantly predict lower mental well-being and higher loneliness after controlling for age and gender. Internalised stigma accounted for a significant 39.3% of the variance in loneliness, and a significant 12.6% of the variance in mental well-being. Correlations supported the hypothesis that higher loneliness would significantly, negatively correlate with mental well-being after controlling for age. Findings aligned with prior research and supported Corrigan. Limitations of the study are discussed, including the small sample size and the cross-sectional, self-report research design. Identified areas of focus for future research and practice include consideration of other associates of internalised stigma for sex workers, as well as lessening the consequences of stigmatisation for sex workers through reduction of its internalisation.
A low-power NMOS transmit/receive IC filter for PCM telephony (1980)

A very low-power single chip NMOS implementation of the transmit and receive PCM filters used in telephony applications is described. The circuit utilizes doubly-terminated switched capacitor low-pass and high-pass filters and meets accepted requirements without trimming. The filters have low idle-channel noise, consume only 20 mW of power, and are realized in a small area of silicon. Design of the overall architecture, the individual filter sections, and the operational amplifiers in NMOS technology is described.
Immune mechanism in senile plaque formation (1994)

Alzheimer disease (AD) is characterized by the appearance of two very different lesions, senile plaques and neurofibrillary tangles (NFTs). The pathological process which causes the disease must be responsible for both, but how they are linked is still a mystery. Neurofibrillary tangles develop intracellularly and involve the appearance of abnormally phosphorylated forms of tau. Senile plaques develop extracellularly with the deposition of beta-amyloid protein (BAP), a component of the larger amyloid precursor protein (APP). Neurofibrillary tangles are not unique to AD. They appear in a number of degenerative neurological diseases in which senile plaques are absent. This is an argument against NFTs causing the appearance of senile plaques. Conversely, extracellular deposits of BAP occur in areas where NFTs do not develop, indicating that BAP deposits, by themselves, do not cause NFTs. However, when senile plaques “mature”, dystrophic neuntes which contain abnormally phosphorylated tau are always present. Thus, it is possible that NFTs evolve from developing senile plaques.
Safety and Outcomes of Magnetic Resonance Imaging in Patients with Abandoned Pacemaker and Defibrillator Leads (2014)

The use of MRI in patients with abandoned cardiac device leads appears feasible when performed under careful monitoring, with no adverse events, although the experience is small. MRI did not affect the function of leads that were subsequently reconnected to a cardiac device.
Effect of director distortions on morphologies of phase separation in liquid crystals (2002)

We study phase separation from a nematic liquid crystal with spatially nonuniform director gradients. Particles of a phase-separated component, which is either an isotropic fluid (silicone oil) or a nonmesogenic photopolymer, accumulate in the regions with the strongest director distortions, thus reducing the overall energy of the system.
Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings (2022)

Two articles in this week’s issue focus on the use of ipilimumab and decitabine for patients with myelodysplasia (MDS) and acute myeloid leukemia (AML) before and after hematopoietic stem cell transplantation (HSCT) for high-risk disease. In the first article, Garcia et al report on the results of a phase 1 trial of the combination in 54 patients, demonstrating overall response rate of 52% in patients who are HSCT-naïve and 20% in patients post-HSCT; responses are usually short-lived. In the second article, Penter and colleagues characterize gene expression responses to therapy and conclude that decitabine acts directly to clear leukemic cells while ipilimumab acts on infiltrating lymphocytes in marrow and extramedullary sites. Responses are determined by leukemic cell burden and by the frequency and phenotype of infiltrating lymphocytes. Increasing bone marrow regulatory T cells is identified as a potential contributor to checkpoint inhibitor escape.