gebhart/patrepeval huggingface dataset:
Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases (2017)

Polyadenylation of nascent RNA by poly(A) polymerase (PAP) is important for 3' end maturation of almost all eukaryotic mRNAs. Most mammalian genes harbor multiple polyadenylation sites (PASs), leading to expression of alternative polyadenylation (APA) isoforms with distinct functions. How poly(A) polymerases may regulate PAS usage and hence gene expression is poorly understood. Here, we show that the nuclear canonical (PAPα and PAPγ) and non-canonical (Star-PAP) PAPs play diverse roles in PAS selection and gene expression. Deficiencies in the PAPs resulted in perturbations of gene expression, with Star-PAP impacting lowly expressed mRNAs and long-noncoding RNAs to the greatest extent. Importantly, different PASs of a gene are distinctly regulated by different PAPs, leading to widespread relative expression changes of APA isoforms. The location and surrounding sequence motifs of a PAS appear to differentiate its regulation by the PAPs. We show Star-PAP-specific PAS usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. The Star-PAP-mediated APA of PTEN is essential for DNA damage-induced increase of PTEN protein levels. Together, our results reveal a PAS-guided and PAP-mediated paradigm for gene expression in response to cellular signaling cues.
Sequence-dependent mechanical, photophysical and electrical properties of pi-conjugated peptide hydrogelators (2015)

An investigation of how systematic variation of peptide sequence influences the nanoscale and bulk properties of 1D-nanostructure forming peptide–π–peptide hydrogelators is reported herein.
Goals and feasibility of the deep space quantum link (2021)

In this article, we review the proposed experiments for the Deep Space Quantum Link (DSQL) mission concept aiming to probe gravitational effects on quantum optical systems. Quantum theory and general relativity are the two most successful frameworks we have to describe the universe. These theories have been validated through experimental confirmations in their domains of application— the macroscopic domain for relativity, and the microscopic domain for quantum theory. To date, laboratory experiments conducted in a regime where both theories manifest measurable effects on photons are limited. Satellite platforms enable the transmission of quantum states of light between different inertial frames and over distances impossible to emulate in the laboratory. The DSQL concept proposes simultaneous tests of quantum mechanics and general relativity enabled by quantum optical links to one or more spacecrafts.
The impact of channel count on microseismic event detection for a surface array (2014)

Summary One of the many questions to be addressed when designing a surface monitoring array is how many channels should be deployed. In addition to geophysical factors the answer will depend on operational constraints, processing strategy (algorithms), and economics in the context of the objectives of the survey. Here we look at data from a single stage treatment of a vertical well which was monitored by a surface array comprising of some 2500 vertical component geophone strings. We will look at the impact of decimating the array on the detection and location of microseismic events for a phase-squared scanning algorithm.
Nonequilibrium simulations of model ionomers in an oscillating electric field (2016)

We perform molecular dynamics simulations of a coarse-grained model of ionomer melts in an applied oscillating electric field. The frequency-dependent conductivity and susceptibility are calculated directly from the current density and polarization density, respectively. At high frequencies, we find a peak in the real part of the conductivity due to plasma oscillations of the ions. At lower frequencies, the dynamic response of the ionomers depends on the ionic aggregate morphology in the system, which consists of either percolated or isolated aggregates. We show that the dynamic response of the model ionomers to the applied oscillating field can be understood by comparison with relevant time scales in the systems, obtained from independent calculations.
Initial results for airframe shadowing in L- and C-band air-ground channels (2015)

In order to ensure the reliability of unmanned aircraft system (UAS) control and non-payload communication (CNPC) systems, comprehensive characterization of the air-ground (AG) radio propagation channel is vital. As part of the UAS integration into the National Airspace System (NAS), NASA's Glenn Research Center has sponsored an AG channel measurement and modeling campaign in the two UAS CNPC bands (L-band centered at 968 MHz and C-band at 5060 MHz). Measurements have been made in multiple ground site environments with a customized dual-band single-input/multiple-output (SIMO) channel sounder. In this paper we report on experimental data collected in Cleveland, OH, in which airframe shadowing occurred. Airframe shadowing (or blockage, obstruction) is a channel impairment that has not been well characterized. When shadowing occurs, typically during flight maneuvers such as banking turns, the line-of-sight (LOS) signal may be blocked by the aircraft wing or fuselage. This blockage can cause significant attenuation, in some cases enough to sever the communication link. In this paper we provide a brief motivation for our study, describe the measurements, then quantitatively characterize initial airframe shadowing results in the two UAS bands. We provide statistics on shadowing depth and duration. Small scale fading behavior and spatial correlation of multiple aircraft antennas during shadowing events are also compared with those in LOS conditions.
An unusual by-product from a non-synchronous reaction between ethyl 1,2,4-triazine-3-carboxylate and an enamine (1998)

The main product from the reaction of ethyl 1,2,4-triazine-3-carboxylate 3 and the pyrrolidine enamine of N-tert-butoxycarbonylpiperidone 2 was an azabicyclo[3.2.1]octane 4 which resulted not from a Diels–Alder reaction, but from a series of non-synchronous steps, demonstrating a heretofore unknown reaction pathway for the electron-deficient diene 3 and electron-rich dienophile 2.
4 Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by β2-adrenergic agonists (1998)

Conference Article| November 01 1998 4 Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by β2-adrenergic agonists Ian D. Waddell; Ian D. Waddell 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Pam Ruddock; Pam Ruddock 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Katy J. Brocklehurst; Katy J. Brocklehurst 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Jackie M. Wilbraham; Jackie M. Wilbraham 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Vivienne Worral; Vivienne Worral 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Brian R. Holloway Brian R. Holloway 1Cardiovascular, Metabolism & Musculoskeletal Research Department, ZENECA Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire. SK10 4TG U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1998) 26 (4): S311. https://doi.org/10.1042/bst026s311 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Ian D. Waddell, Pam Ruddock, Katy J. Brocklehurst, Jackie M. Wilbraham, Vivienne Worral, Brian R. Holloway; 4 Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by β2-adrenergic agonists. Biochem Soc Trans 1 November 1998; 26 (4): S311. doi: https://doi.org/10.1042/bst026s311 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1998 Biochemical Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.
Design of a Multiband OFDM System for Realistic UWB Channel Environments (2004)

In February 2002, the Federal Communications Commission allocated 7500 MHz of spectrum for unlicensed use of commercial ultra-wideband (UWB) communication devices. This spectral allocation has initiated an extremely productive activity for industry and academia. Wireless communications experts now consider UWB as available spectrum to be utilized with a variety of techniques, and not specifically related to the generation and detection of short RF pulses as in the past. There are many differences between real-world behavior of narrow-band and UWB systems. All wireless systems must be able to deal with the challenges of operating over a multipath propagation channel, where objects in the environment can cause multiple reflections to arrive at the receiver (RX). For narrow-band systems, these reflections will not be resolvable by the RX when the narrow-band system bandwidth is less than the coherence bandwidth of the channel. The large bandwidth of UWB waveforms, instead, significantly increases the ability of the RX to resolve the different reflections in the channel. The UWB channel model developed by the IEEE 802.15.3a standard body is described in this paper. For highly dispersive channels, an orthogonal frequency-division multiplexing (OFDM) RX is more efficient at capturing multipath energy than an equivalent single-carrier system using the same total bandwidth. OFDM systems possess additional desirable properties, such as high spectral efficiency, inherent resilience to narrow-band RF interference, and spectral flexibility, which is important because the regulatory rules for UWB devices have not been finalized throughout the entire world. This paper describes the design of a UWB system optimized for very high bit-rate, low-cost, and low-power wireless networks for personal computing (PC), consumer electronics (CE), and mobile applications. The system combines OFDM modulation technique with a multibanding approach, which divides the spectrum into several sub-bands, whose bandwidth is approximately 500 MHz. The system described in this paper has been selected by several key industry organizations [Mulitband OFDM Alliance, WiMedia, Wireless Universal Serial Bus (USB)] because of its very good technical characteristics for the diverse set of high performance short-range applications that are eagerly anticipated for CE, PC, and mobile applications.
Experimental and Numerical Investigation of 65-deg Delta and 65/40-deg Double-Delta Wings in Sideslip (2010)

In this study, an experimental and numerical investigation is being carried out to obtain lift, drag, side force, pitching moment, yawing moment and rolling moment data for 65-deg delta and 65/40-deg double-delta wings at various pitch and sideslip angles. The experimental tests were conducted at the KFUPM low-speed wind tunnel facility whereas the numerical tests are being performed using the commercial CFD software FLUENT. Results for zero sideslip angles from both experiments and numerical predictions were compared to other experimental data found in literature as well as to the theory of Polhamus. The results of comparison of surface pressure coefficient distribution and vortex breakdown location show good agreement with experiments. Overall the comparison of result shows good agreement between different experimental studies as well as good agreement with the CFD predictions and the theoretical calculations at zero sideslip angles. Experimental results for various pitch and sideslip angles have been completed and included in this abstract. Numerical computations for non-zero sideslip angles are currently underway and will be included in the final paper. An extended abstract of the work that has been accomplished is given in the following sections.
Terminal deoxynucleotidyl transferase is found in prothymocytes (1976)

Terminal deoxynucleotidyl transferase is an enzyme which has the unique property of polymerizing polydeoxynucleotides onto a primer in the absence of a template (1,2). This enzyme is found both in the thymus and the bone marrow of birds, rodents, and humans (3-7). Whether the marrow cells that contain terminal transferase are related to thymocytes, or are on a separate pathway of differentiation, is not yet known (7,8). To determine the lineage of the murine bone marrow cells that have terminal transferase, we have investigated whether these cells have the antigen Thy-1 induced on the cells by treatment with thymopoietin (9). Thymopoietin is known to induce a set of characteristic T-cell markers including the Thy-1 alloantigen on the surface of a subpopulation of bone marrow cells committed to T-cell differentiation (prothymocytes) (10). Destruction of Thy- 1-positive cells after exposure to thymopoietin allows elimination of a substantial fraction of those bone marrow cells that can repopulate an irradiated thymus (11). We find that such an elimination after induction with the thymic polypeptide removes a substantial amount of terminal transferase from the bone marrow cell population, suggesting that at least one-half of the marrow cells bearing this enzyme are related to those found in the thymus.
A Cluster-Based Analysis of Outdoor-to-Indoor Office MIMO Measurements at 5.2 GHz (2006)

In this paper, we present a cluster based analysis of an outdoor-to-indoor Multiple-Input Multiple-Output (MIMO) measurement campaign, and extract model parameters for the COST273 channel model. The measurements were performed at 5.2 GHz for 159 measurement locations in an office building. Multipath component (MPC) parameters have been extracted for these positions using a high-resolution algorithm. We analyze the clustering of MPCs, i.e., grouping together of MPCs with similar DOAs, DODs, and delays. We compare cluster identification by visual inspection to automatic identification by the recently proposed algorithm of Czink et al. In the paper we include results on the intercluster properties such as the distribution of the number of clusters and the cluster powers, as well as intracluster properties such as the angle and delay spreads within the clusters. In particular, we extract parameters for the COST 273 channel model, a standardized generic model for MIMO propagation channels.
The Vicenza “Short” Peritoneal Catheter: A Twenty Year Experience (2006)

Dislocation of peritoneal dialysis catheters is one of the major causes of technique failure. We evaluated 701 Vicenza catheters, implanted since 1985 in 365 males, mean age 53 +/- 16 yrs, range 24 - 87, and 336 females, mean age 51 +/- 17 yrs, range 21 - 82. The Vicenza catheter is defined "short" since it consists of a classic straight double cuff PD catheter having however an inner segment (the portion located in the peritoneal cavity) much shorter than any other type of catheter. It is implanted in the lower abdomen, just a few centimeters above the pubis. The analysis of our results obtained in a large PD population displayed good device survival at 2 and 5 years (94.3% and 91.5% respectively), a low dislocation rate (4%) and an exit-site infection rate similar to other double cuffed catheters. There was no selection of patients receiving this catheter since from 1985 we have used this catheter in every incident patient. Due to its lower implantation site this catheter demonstrates excellent wearability and good body image acceptance.
The ARC Display: an augmented reality visualization center (2003)

The ARC Display represents a significant advancement towards our vision of wearable displays for multimodal augmented reality systems. The ARC Display currently provides a unique theatre for stereoscopic viewing of computer-generated objects. Moreover, users within the environment may be tracked using commercially available tracking systems. In our environment, we use custom designed probes built on the Polaris optical tracking system.
Potential Non-Tertiary Additional Oil Recovery from Heterogeneous Submarine-Fan Reservoirs, Spraberry-Benedum Field, Midland Basin, Texas: ABSTRACT (1987)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A Metal-Via Resistance Based Physically Unclonable Function With Backend Incremental ADC (2021)

This paper presents a novel physically unclonable function (PUF) for security authentication. Instead of using the variation of transistors or PDK provided passive components as entropy source, the parasitic resistance created between metal and via layers is used as the static entropy source. A symmetric bridge configuration consisted with the parasitic resistance creates the necessary voltage difference for comparison. An accurate backend incremental analog-to-digital converter (IADC) is implemented to convert the voltage difference into a digitized value. The operation of the IADC allows to achieve a good native instability. Two different types of layout structures are implemented to create the necessary parasitic resistance and compared. Fabricated in a 65nm process, the prototype PUF achieves a native instability and bit error rate of less than 1.45% and 0.12% with 5000 repeated evaluations. The proposed design shows 0.58%/0.1V and 0.53%/10°C bit error across the voltage and temperature range of 0.9 to 1.4V and 0°C to 85°C, respectively without any stabilization techniques. The distance ratio between intra-die and inter-die Hamming Distance is above <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$305\times $ </tex-math></inline-formula> .
Figures S7 - S9 from Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma (2023)

&lt;p&gt;Figures S7, S8 and S9 - PDF file 206K, SMAD1 expression in patients and functional experiments&lt;/p&gt;
DB-DTFC as loss minimizing control for synchronous reluctance drives (2015)

This paper applies deadbeat-direct torque and flux control (DB-DTFC) to minimize machine and inverter losses in synchronous reluctance drives each single switching period. Flux linkage-based loss models for machine and inverter considering nonlinear effects such as cross-saturation and temperature changes are experimentally evaluated. Loss minimizing capabilities are demonstrated comparing three different control strategies. It is shown experimentally that incorporating inverter losses into the control algorithm and minimizing losses of machine and inverter instead of only considering machine losses leads to a reduction of total losses.
Improvement of purity of produced15O beams for OpenPET (2015)

In ion therapy, it is ideal to use radioactive ion beams for in-beam positron emission tomography (PET) imaging in order to visualize the irradiation field for treatment. In cancer treatment with light ions, <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> O beam is a good candidate for tumor treating and monitoring the delivery of the dose by (PET) imaging. Moreover, a combination of different positron emitter ions, such as <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> C and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> O, might be favorable for a selected clinical situation in the near future for radiation therapy. We have recently produced <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> O beams in the Heavy Ion Medical Accelerator in Chiba (HIMAC) using an optimized target of polyethylene. But the purity of the produced beams was around 75%, which is not satisfactory for clinical utilization. Therefore in this study we focused on improvement of the purity of the produced beam by adding a wedge-shaped degrader within the beam line. We inserted an aluminum degrader with the thickness of 1.76 cm into the secondary beam line. The purity of the produced beam for the polyethylene target with thicknesses of 5 cm and 11 cm were measured. The in-beam PET images of the produced beams with and without the aluminum degrader in the beam line were obtained using our whole-body dual-ring OpenPET system. The purity of the beam produced by inserting the degrader into the beam line was increased from 75% to 97%.
Role of Carbon Porosity and Ion Size in the Development of Ionic Liquid Based Supercapacitors (2010)

The role played by carbon porosity and electrolyte chemistry in the development of double-layer supercapacitors based on solvent-free ionic liquids (ILs) of wide electrochemical stability window is investigated. Voltammetric studies performed in N-methyl-N-butyl-pyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI), N-trimethyl-N-propylammonium bis(trifluoromethanesulfonyl)imide (N1113TFSI), N-methyl-N-butyl-pyrrolidinium tris(pentafluoroethyl)trifluorophosphate (PYR14FAP) ionic liquids, and PYR14TFSI – tetraethyl ammonium bis(trifluoromethanesulfonyl)imide (N2222TFSI) solutions demonstrate that the pore-to-ion size ratio and porous electrode/IL interface properties may have a higher impact on electrode electrical response than the inherent IL bulk properties. The effect of carbon porosity on the electrode capacitance and charge storage capability in both the positive and negative potential domains is discussed in relation to the IL properties and an estimation of the upper limits of the performance of IL-based supercapacitors with carbons of optimized porosity is reported .