gebhart/patrepeval huggingface dataset:
Living Carbocationic Polymerization. LII. Living Carbocationic Copolymerization of Indene andp-Methylstyrene. 2. Synthesis, Characterization, and Physical Properties of Poly((Indene-co-p-Methylstyrene)-b-Isobutylene-b-(Indene-co-p-Methylstyrene)) Thermoplastic Elastomers (1993)

Abstract Novel thermoplastic elastomers (TPEs) consisting of a central rubbery polyisobutylene (PIB) segment flanked by two glassy outer segments comprising indene (Ind)-co-p-methylstyrene (pMeSt) random copolymers have been prepared. The synthesis was effected by sequential monomer addition in one reactor: The process starts by the biliving homopolymerization of isobutylene (IB) and yields the living dication +PIB+; the latter, upon the introduction of Ind/pMeSt mixtures, induces the living copolymerization of these monomers and yields the target TPE P(Ind-co-pMeSt)-b-PIB-b-P(Ind-co-pMeSt) triblock. The length of the rubbery midblock and the composition of the Ind-co-pMeSt random copolymer outer blocks (i.e., the overall composition of the triblocks) can be readily controlled. The glass transition temperature (Tg ) of the outer blocks can be fine-tuned by controlling the relative Ind/ pMeSt composition. The triblocks are excellent TPEs; for example, a P(Ind-co-pMeSt)-b-PIB-b-P(Ind-co-pMeSt) of M n ≈ 115,000 g/mol containing a PIB midblock of M n ≈ 70,200 g/mol and glassy copolymer outer blocks of P(Ind-co-pMeSt) [Ind/pMeSt = 41/59 (w/w)] exhibited 23.4 MPa tensile strength and 460% elongation. Tensile strengths and 300% moduli increase with the relative amount of the glassy segment present. Hardness increases with increasing Ind content.
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (2003)

SU5416 single agent is well tolerated. The antitumor response was low in patients with RCC and STS, whereas no responses were seen in patients with M.
Purification of a heparin-neutralizing protein from rabbit platelets and its homology with human platelet Factor 4. (1979)

A heparin-neutralizing protein was purified in 50% yield from a rabbit platelet extract by heparin-sepharose affinity chromatography. The specific heparinneutralizing activity of this protein was 185 + 32 units/ mg. The purified protein gave a single Coomassie bluestaining band in sodium dodecyl sulfate polyacrylamide gel electrophoresis in the presence and absence of mercaptoethanol. In immunodiffusion analysis, an antibody raised against the purified material produced a single line of identity when reacted against the immunogen or against solubilized platelets. This rabbit platelet protein was compared with purified human platelet factor 4. Both proteins eluted from heparin-Sepharose at similar salt concentrations (1 to 1.5 M NaCl) and had similar heparin-neutralizing activities (rabbit = 185 units/mg, human = 225 units/ mg). A mixture of the two proteins co-sedimented into a 5 to 20% linear sucrose gradient. The 1311-labeled rabbit protein migrated as an apparently larger species when it was co-electrophoresed with lZ51-labeled human platelet factor 4 in sodium dodecyl sulfate polyacrylamide gels. This apparent size difference was corroborated by a corresponding difference in the minimum molecular weights calculated from amino acid compositions (rabbit = 8900, human = 7767). Nevertheless, the amino acid compositions of the two proteins were highly similar, both lacking phenylalanine, methionine, and tryptophan and having a minimum of 1 tyrosine per mole. The human platelet factor 4 bound to goat antibodies to rabbit protein and could displace the rabbit protein in a competitive radioimmunoassay for the rabbit protein. This indicated shared antigenic determinants between the two proteins. Finally, and most significantly, there was a high degree of NHz-terminal amino acid sequence identity when Cys residues of both proteins were aligned. Thus, by criteria including size, activity, amino acid composition, immunological crossreactivity, and partial amino acid sequence identity, the rabbit platelet heparin-neutralizing protein is homologous with human platelet factor 4. It is proposed that this protein be termed “rabbit platelet factor 4.”
Flow cytometric quantitation of the proliferation-associated nuclear antigen p105 and DNA content in advanced gastric cancers (1991)

Flow cytometric quantitation of the proliferation-associated nuclear antigen p105 was done on cancer cell suspensions from 114 advanced gastric cancers and correlated with clinical behavior. DNA diploidy was observed in 45 (39.5%) and aneuploidy in 69 (60.5%) cases. By setting the cutoff line at the level used in a negative control study without primary antibody in the same sample, the p105-labeling rate was calculated by the p105-DNA dual fluorescence analysis. The mean p105-labeling rate was 37.7% (range, 9.3% to 79.0%). The p105-labeling rates were significantly higher (P less than 0.05) for aneuploid DNA, liver metastasis, vascular invasion, and histologically well-differentiated tumors. The 5-year survival rate of patients with high p105-labeling tumors (p105-labeling rate, greater than 30%) was significantly poorer (P less than 0.01) than that of patients with low-labeling tumors. When the p105-labeling rate and the clinicopathologic parameters were entered simultaneously into the Cox regression model, the stage of disease, DNA ploidy, p105-labeling rate, and vascular invasion emerged as independent prognostic parameters. These findings indicate that the measurement of p105 may provide useful information for predicting prognosis in advanced gastric cancers.
Dataset for "Ge-on-Si modulators operating at mid-infrared wavelengths up to 8 um" (2019)

Data supports the paper Li, T., Nedeljkovic, M., Hattasan, N., Cao, W., Qu, Z., Littlejohns, C., Soler Penades, J., Mastronardi, L., Mittal, V., Benedikovic, D., Thomson, D., Gardes, F., Wu, H., Zhou, Z. &amp; Mashanovich, G., (2019) Ge-on-Si modulators operating at mid-infrared wavelengths up to 8 μm Photonics Research.
Engineering and the Engineer (2013)

This chapter contains sections titled: Engineering Defined, Concurrent Engineering and Biology, 1850–1880
Cell segmentation and classification by hierarchical supervised shape ranking (2015)

While pathologists can readily elucidate disease-relevant information from tissue images, automated algorithms may fail to capture the intricate details of complex biological specimens. As histology patterns vary depending on different tissue types, it is typically necessary to adapt and optimize segmentation algorithms to specific applications. To address this, we present a supervised machine learning method we call Support Vector Shape Segmentation (SVSS) to enhance and improve more general segmentation methods by utilizing a cell shape ranking function. First, we pose shape segmentation as an optimization problem that maximizes shape similarity with respect to the specific shape classes. Secondly, we propose a computationally efficient algorithm to solve the multi-scale segmentation problem in a minimum number of steps. The main advantage of the approach is that it naturally induces a ranking measure given the set of shape exemplars. We demonstrate large-scale quantitative and qualitative results on epithelial cells in a range of tissue types.
Precise Chemical Polishing of Aluminum Alloys for UHV Wall. (1998)

Chemical polishing (CP) is advantageous for low-cost polishing of metallic objects with complex shapes. But conventional CP has not been sufficiently developed to be applied to materials used in ultrahigh vacuum (UHV) and extremely high vacuum (XHV) systems. Therefore, we developed a CP process optimized for application to UHV and XHV materials that uses a solution of phosphoric and nitric acids and an additional cleaning process. Using this optimized CP process, the degree of outgassing of chemically polished aluminum is comparable to the outgassing achieved with special extrusion and ethanol lathing processes. This optimized CP process can be used for regular surface treatment of aluminum alloys used in both UHV and XHV chambers and related equipment.
Optimal Signaling Strategies for Symmetric and Asymmetric Bit-Rate Communication Services in the Presence of Crosstalk (1999)

1 Spectral optimization and joint signaling techniques for communication in the presence of crosstalk
ChemInform Abstract: Synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis of Dithioallenes and (α‐Dithiocarboxyvinyl) phosphonates. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of CdCl2 Treatment in CdTe Thin Film Grown on Ultra-Thin Glass Substrate via Close Spaced Sublimation (2021)

In this study, close-spaced sublimation (CSS) grown cadmium telluride (CdTe) thin films with good adhesion to 100 µm thin Schott D263T ultra-thin glass (UTG) were investigated. Cadmium chloride (CdCl2) treatment in vacuum ambient was executed to enhance the film quality and optoelectrical properties of CdTe thin film. The post-deposition annealing temperature ranging from 360–420 °C was examined to improve the CdTe film quality on UTG substrate. Various characterization techniques have been used to observe the compositional, morphological, optical, as well as electrical properties. Scanning electron microscopy (SEM) verified that the CdTe morphology and grain size could be controlled via CdCl2 treatment temperature. Energy Dispersive X-Ray Analysis (EDX) results confirmed that the annealing temperature range of 375–390 °C yielded the stoichiometric CdTe films. UV-Vis analysis estimated the post-treatment bandgap energy in the range of 1.39–1.46 eV. Carrier concentration and resistivity were obtained in the order of 1013 cm−3 and 104 Ω-cm, respectively. All the experimental results established that the CdCl2 treatment temperature range of 390–405 °C might be considered as the optimum process temperature for the deposition of CdTe solar cell on UTG substrate in close-spaced sublimation (CSS) method.
Combined analysis of all three phases of solar neutrino data from the Sudbury Neutrino Observatory (2013)

We report results from a combined analysis of solar neutrino data from all phases of the Sudbury Neutrino Observatory (SNO). By exploiting particle identification information obtained from the proportional counters installed during the third phase, this analysis improved background rejection in that phase of the experiment. The combined analysis of the SNO data resulted in a total flux of active neutrino flavors from B-8 decays in the Sun of (5.25 +/- 0.16(stat.)(-0.13)(+0.11)(syst.)) x 10(6) cm(-2)s(-1), while a two-flavor neutrino oscillation analysis yielded Delta m(21)(2) = (5.6(-1.4)(+1.9)) x 10(-5) eV(2) and tan(2) theta(12) = 0.427(-0.029)(+0.033). A three-flavor neutrino oscillation analysis combining the SNO result with results of all other solar neutrino experiments and reactor neutrino experiments yielded Delta m(21)(2) = (7.46(-0.19)(+0.20)) x 10(-5) eV(2), tan(2) theta(12) = 0.443(-0.025)(+0.030), and sin(2) theta(13) = (2.49(-0.32)(+0.20)) x 10(-2).
Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma (2022)

Ductal carcinoma in situ (DCIS) is considered a non-invasive precursor to breast cancer, and although associated with an increased risk of developing invasive disease, many women with DCIS will never progress beyond their in situ diagnosis. The path from normal duct to invasive ductal carcinoma (IDC) is not well understood, and efforts to do so are hampered by the substantial heterogeneity that exists between patients, and even within patients. Here we show gene expression analysis from > 2,000 individually micro-dissected ductal lesions representing 145 patients. Combining all samples into one continuous trajectory we show there is a progressive loss in basal layer integrity heading towards IDC, coupled with two epithelial to mesenchymal transitions, one early and a second coinciding with the convergence of DCIS and IDC expression profiles. We identify early processes and potential biomarkers, including CAMK2N1, MNX1, ADCY5, HOXC11 and ANKRD22, whose reduced expression is associated with the progression of DCIS to invasive breast cancer.
Hierarchical Chirality in Polycarbodiimides (2011)

Abstract Non‐linear or helical polycarbodiimides feature a nitrogen‐rich fully substituted guanidine‐like backbone repeat unit with two synthetically selective pendant groups. As a result of a complex ballet of bond rotations within steric proximity of the backbone, these polymers can adopt multiple tiers of asymmetry. Primary locales of chiral influence incorporated onto the polymer or on the catalyst during polymerization permit amplification to secondary levels of chirality through a backbone with an excess helical sense. In turn, the conformational chirality of the helix promotes hierarchical orders of tertiary chirality around this chiral scaffolding. These higher levels of asymmetry have shown static and dynamic attributes and can be obtained from monomers containing no predominant chirality. Tailoring these properties with the selection of spatially constricting pendant groups such as substituted arenes, polyarenes, and enantiopure configurationally chiral alkanes has exemplified this behavior. This manuscript will focus on some of the highlights of dynamic and static asymmetry observed for these polycarbodiimide systems.
Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer – the INNODIAG study (2015)

We confirmed the use of fuzzy logic selection as a new tool to identify gene signatures with good reliability and increased classification power. This method based on artificial intelligence algorithms was successfully applied to breast cancers molecular grade classification allowing histologic grade 2 classification into grade 1 and grade 2 like to improve patients prognosis. It opens the way to further development for identification of new biomarker combinations in other applications such as prediction of treatment response.
New Beginnings for Matrix Metalloproteinase Inhibitors:  Identification of High-Affinity Zinc-Binding Groups (2004)

In an effort to identify promising non-hydroxamate inhibitors of matrix metalloproteinases (MMPs), several new zinc-binding groups (ZBGs) based on pyrone, pyrothione, hydroxypyridinone, and hydroxypyridinethione chelators have been examined. Structural studies with tris(pyrazolyl)borate model complexes show that these ligands bind to the MMP active site zinc(II) ion in a bidentate fashion, similar to that found with hydroxamate-based inhibitors. Fluorescence- and colorimetric-based enzyme assays have been used to determine the IC50 values for these ZBGs against MMP-3; mixed O,S-donor ligands were found to be remarkably potent, with IC50 values as much as 700-fold lower than that found for acetohydroxamic acid. Inhibitory activity was found to parallel metal binding affinity as determined in titrations with model complexes. These results demonstrate that MPIs based on new ZBGs are feasible and may indeed improve the overall performance of inhibitors designed against these important medicinal targets.
Supplementary document for Holographic Pancake Optics for Thin and Lightweight Optical See-through Augmented Reality - 5482809.pdf (2021)

Supplement 1
Dual-SiC Photodiode Devices for Simultaneous Two-Band Detection (2005)

SiC is a highly useful material for optical sensing devices in the UV due to its large bandgap. It also exhibits a robust physical nature, making it suitable for harsh environment applications such as flame sensing. Here we report the first demonstration of SiC photodiode devices with multiple, independent detection components for sensing more than one radiation band simultaneously. The fabrication process and layout of the devices is described along with optical and electrical measurements of their performance. Individual sensing components exhibited peak responsivities greater than 60 mA/W at wavelengths of 290 and 320 nm. Optically tailored SiC devices, such as the ones described here, may further be applied to other applications such as missile plume detection, engine control, and communications in the solar-blind window. The application of particular interest for these devices was for flame temperature sensing. Testing the dual-SiC photodiode devices in front of a combustion flame showed a significant and linear dependence of the photodiode's output ratio with temperature, demonstrating its feasibility. Successful determination of flame temperature would be a major improvement in the control and optimization of combustion processes. © 2005 The Electrochemical Society. All rights reserved.
Subjecting Legacy Simulink Models to Timing Specifications. (2018)

The interest in the logical execution time (LET) paradigm has recently experienced a boost, especially in the automotive industry. This is because it is considered a practical candidate for migrating concurrent legacy software from single- to multi-core platforms by introducing deterministic intra- and inter-core communication. In many cases, the implementation of these individual software components roots in MATLAB/Simulink, a modeling and simulation environment, where the controller functionality is described with a block-oriented formalism and simulated with synchronous reactive semantics. Considering LET already in the modeling and simulation phase instead of deferring this to the integration phase, as it is done now, is an important step towards the idea of models being the single source of truth and to estimate the effect of LET on end-to-end timing in cause-effect-chains at an early stage. This paper presents two approaches of simulating software components with LET semantics in Simulink. In contrast to previous work, which deals with clean slate top-down approaches, we focus on legacy software (in the form of Simulink models) that does not satisfy some of the initial assumptions of the LET programming model.
Gabapentin for the treatment of pain syndrome related to radiation‐induced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy (2010)

Gabapentin appears to be promising in reducing the need for high total doses of opioids and avoiding unplanned treatment interruptions for patients with head and neck malignancies treated with concurrent chemoradiotherapy and should be further evaluated prospectively in controlled clinical trials.
What is Mechanisms Expected for Robotics and Mechatronics? (2016)

IoT(Internet of Things) 4 Industry4.0AI (Artificial Intelligence) ICT(Information and Communication Technology
Supplementary Table 1 from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells (2023)

&lt;p&gt;PDF file - 2927KB, Cell surface vimentin expression in different sarcoma cell lines.&lt;/p&gt;
The Effect of Ethanol on the Release of Opioids from Oral Prolonged-Release Preparations (2007)

Recent experience has prompted the US FDA to consider whether ethanol ingestion may modify the release characteristics of prolonged-release formulations, where dose dumping may be an issue for patient safety. The influence of ethanol on the in vitro release of opioid drugs from some prolonged-release formulations utilizing different release technologies was examined. Results indicated that the prolonged-release mechanisms remained intact under the testing conditions, although one product showed initial sensitivity to ethanol in its release characteristics. Nevertheless, in this case, extrapolation of the findings to likely outcome in vivo indicated no risk of dose-dumping. It is proposed that prolonged-release medicinal products should be tested during development to ensure robustness to the effects of ethanol on drug release.
Formulation Study for Lansoprazole Fast-disintegrating Tablet. II. Effect of Triethyl Citrate on the Quality of the Products (2003)

The purpose of this study was to develop enteric-coated microgranules for the lansoprazole fast-disintegrating tablet (LFDT), which is a rapidly disintegrating tablet containing enteric-coated microgranules. In our previous study, it was clarified that sufficient flexibility of the enteric layer was achieved by the optimized combined ratio of methacrylic acid copolymer dispersion to ethyl acrylate-methyl methacrylate copolymer dispersion and adding the optimized concentration of triethyl citrate to reduce the damage during the compression process. However, since triethyl citrate has an unpleasant bitter taste and is especially incompatible with lansoprazole, it adversely affects the taste and stability of lansoprazole in the enteric-coated microgranules. The enteric layer containing macrogol 6000 was proven useful to improve the unpleasant bitter taste and stability of lansoprazole, because macrogol 6000 does not have an unpleasant bitter taste and is more compatible than triethyl citerate. By covering the inner (first enteric layer) and outer side (third enteric layer) of the enteric layer containing triethyl citrate (second enteric layer) with the enteric layer containing macrogol 6000, we resolved the stability problem of lansoprazole and the unpleasant bitter taste. Finally, we developed enteric-coated microgranules comprising seven layers: 1) core, 2) active compound layer, 3) intermediate layer, 4) first enteric layer, 5) second enteric layer, 6) third enteric layer, and 7) over coating layer. The enteric-coated microgranules have the multiple functions of reducing the damage to the enteric layer during the compression process, improving the stability of lansoprazole, and masking the unpleasant bitter taste.
Search for the Flavor-Changing Neutral-Current DecaysD+→π+μ+μ−andD+→π+e+e− (1996)

We report the results of a search for the flavor-changing neutral-current decays ${D}^{+}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ and ${D}^{+}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{e}^{+}{e}^{\ensuremath{-}}$ in data from Fermilab charm hadroproduction experiment E791. No signal above background is found, and we obtain upper limits on branching fractions, $B({D}^{+}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}})&lt;1.8\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ and $B({D}^{+}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{e}^{+}{e}^{\ensuremath{-}})&lt;6.6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$, at the 90% confidence level.
High‐Efficiency Deep‐Blue‐Phosphorescent Organic Light‐Emitting Diodes Using a Phosphine Oxide and a Phosphine Sulfide High‐Triplet‐Energy Host Material with Bipolar Charge‐Transport Properties (2010)

Highly efficient deep-blue-phosphorescent organic light-emitting diodes have been developed using bipolar-type high-triplet-energy host materials with a carbazole core and two phosphine oxide (PPO21) or phosphine sulfide (PPS21) units. A high quantum efficiency of 19.2% with a deep-blue color coordinate of (0.14,0.16) was achieved in the deep-blue device with PPO21 as a host material (see figure).