gebhart/patrepeval huggingface dataset:
Toward orthogonal self-assembly of redox active molecules on platinum and gold: selective reaction of disulfide with gold and isocyanide with platinum (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward orthogonal self-assembly of redox active molecules on platinum and gold: selective reaction of disulfide with gold and isocyanide with platinumJames J. Hickman, Paul E. Laibinis, David I. Auerbach, Chaofeng Zou, Timothy J. Gardner, George M. Whitesides, and Mark S. WrightonCite this: Langmuir 1992, 8, 2, 357–359Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/la00038a005https://doi.org/10.1021/la00038a005research-articleACS PublicationsRequest reuse permissionsArticle Views786Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bob and Alice Go to a Bar: Reasoning About Future With Probabilistic Programs (2021)

It is well known that reinforcement learning can be cast as inference in an appropriate probabilistic model. However, this commonly involves introducing a distribution over agent trajectories with probabilities proportional to exponentiated rewards. In this work, we formulate reinforcement learning as Bayesian inference without resorting to rewards, and show that rewards are derived from agent's preferences, rather than the other way around. We argue that agent preferences should be specified stochastically rather than deterministically. Reinforcement learning via inference with stochastic preferences naturally describes agent behaviors, does not require introducing rewards and exponential weighing of trajectories, and allows to reason about agents using the solid foundation of Bayesian statistics. Stochastic conditioning, a probabilistic programming paradigm for conditioning models on distributions rather than values, is the formalism behind agents with probabilistic preferences. We demonstrate realization of our approach on case studies using both a two-agent coordinate game and a single agent acting in a noisy environment, showing that despite superficial differences, both cases can be modeled and reasoned about based on the same principles.
Methods for the detection and identification of pathogenic bacteria: past, present, and future (2017)

In order to retard the rate of development of antibacterial resistance, the causative agent must be identified as rapidly as possible, so that directed patient treatment and/or contact precautions can be initiated. This review highlights the challenges associated with the detection and identification of pathogenic bacteria, by providing an introduction to the techniques currently used, as well as newer techniques that are in development. Focusing on the chemical basis for these techniques, the review also provides a comparison of their advantages and disadvantages.
Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages (2015)

Inflammation is a protective response to injury, but it can become chronic, leading to tissue damage and disease. Cigarette smoke causes multiple inflammatory diseases, which account for thousands of deaths and cost billions of dollars annually. Cigarette smoke disrupts the function of immune cells, such as macrophages, by prolonging inflammatory signaling, promoting oxidative stress, and impairing phagocytosis, contributing to increased incidence of infections. Recently, new families of lipid-derived mediators, "specialized proresolving mediators" (SPMs), were identified. SPMs play a critical role in the active resolution of inflammation by counterregulating proinflammatory signaling and promoting resolution pathways. We have identified dysregulated concentrations of lipid mediators in exhaled breath condensate, bronchoalveolar lavage fluid, and serum from patients with chronic obstructive pulmonary disease (COPD). In human alveolar macrophages from COPD and non-COPD patients, D-series resolvins decreased inflammatory cytokines and enhanced phagocytosis. To further investigate the actions of resolvins on human cells, macrophages were differentiated from human blood monocytes and treated with D-series resolvins and then exposed to cigarette smoke extract. Resolvins significantly suppressed macrophage production of proinflammatory cytokines, enzymes, and lipid mediators. Resolvins also increased anti-inflammatory cytokines, promoted an M2 macrophage phenotype, and restored cigarette smoke-induced defects in phagocytosis, highlighting the proresolving functions of these molecules. These actions were receptor-dependent and involved modulation of canonical and noncanonical NF-κB expression, with the first evidence for SPM action on alternative NF-κB signaling. These data show that resolvins act on human macrophages to attenuate cigarette smoke-induced inflammatory effects through proresolving mechanisms and provide new evidence of the therapeutic potential of SPMs.
Optimum design of satellite TV antennas for weak signal environment (2008)

This paper describes a process of optimization of corrugated horn feeds for satellite TV antenna applications. Optimization of the feeds was performed using an axisymmetrical version of a Finite Difference Time Domain software. The optimized horns were manufactured in high volume using CNC machines and applied in many TV installations in Cyprus. It is shown that typically more than 1 dB can be gained in the signal-to-noise ratio by optimizing the feed. Practical experience from application of the optimized horns shows that, to achieve the same effect of improvement of antenna performance, investment in horn optimization may be more than an order of magnitude smaller than investment in the increase of reflector size.
Preparation and reactions of a titanium(IV) metallocycle. Formation of cyclopentanone from ethylene and carbon monoxide (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of a titanium(IV) metallocycle. Formation of cyclopentanone from ethylene and carbon monoxideJoseph X. McDermott and George M. WhitesidesCite this: J. Am. Chem. Soc. 1974, 96, 3, 947–948Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/ja00810a068https://doi.org/10.1021/ja00810a068research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A flexible web service based architecture for wireless sensor networks (2004)

The current sensor networks are assumed to be designed for specific applications, having strongly coupled data communication protocols. The future sensor networks are envisioned as comprising heterogeneous devices assisting to a large range of applications. To achieve this goal, a new architecture approach is needed, having application specific features separated from the data communication protocol, while influencing its behavior. We propose a Web Services approach for the design of sensor networks, in which sensor nodes are service providers and applications are clients of such services. Our main goal is to enable a flexible architecture where sensor networks data can be accessed by users spread all over the world.
Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas (2010)

We have shown previously that cancer/testis (CT) antigen, CT45, is expressed in various epithelial cancers at a frequency of <5% to approximately 35%. In this study, the protein expression of CT45 was examined in non-Hodgkin B-cell lymphomas and classical Hodgkin lymphoma by immunohistochemical analysis. Serological response to CT45 was also evaluated by ELISA using CT45 recombinant protein and sera from patients with Hodgkin lymphoma. None of the 80 low-grade B-cell lymphomas, including chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma, expressed CT45. In comparison, CT45 was expressed in 28 of 126 (22%) diffuse large B-cell lymphomas (DLBCL). A remarkably high percentage (42/72, 58%) of classical Hodgkin lymphoma contained CT45-positive Reed-Sternberg cells. Nodular sclerosis and mixed-cellularity subtypes had similar frequency of CT45 expression, but most EBV-positive cases were CT45 negative. Gray-zone lymphoma (cases with features of both DLBCL and classical Hodgkin lymphoma) also showed frequent (64%) CT45 expression. Evaluation of reactive lymphoid tissues showed scattered CT45-positive lymphocytes in a single case of florid follicular hyperplasia, raising the possibility that this case was an evolving malignancy. Despite frequent CT45 expression, only 1 of 67 Hodgkin lymphoma patients had detectable anti-CT45 antibodies in the serum, suggesting that the immune response to CT45 may be suppressed. In conclusion, classical Hodgkin lymphoma has the highest frequency of CT45 expression among all malignancies tested to date, the frequency of CT45 expression in DLBCL is similar to that seen in epithelial cancers, and low-grade non-Hodgkin B-cell lymphomas do not express CT45.
Gene Therapy in Tissue-Engineered Blood Vessels (2003)

Cardiovascular disease is the leading cause of morbidity and mortality in Western society. More than 1 million arterial bypass procedures are performed annually in the United States, where either autologous veins or synthetic grafts are used to replace arteries in the coronary or peripheral circulation. Tissue engineering of blood vessels from autologous cells has the potential to produce biological grafts for use in bypass surgery. Ex vivo development of vascular grafts also provides an ideal target of site-specific gene therapy to optimize the physiology of the developing conduit, and for the possible delivery of other therapeutic genes to a vascular bed of interest. In this article, we demonstrate that by using a novel retroviral gene delivery system, a target gene of interest can be specifically delivered to the endothelial cells of a developing engineered vessel. Further, we demonstrate that this technique results in stable incorporation of the delivered gene into the target endothelial cells for more than 30 days. These data demonstrate the utility of the retroviral gene delivery approach for optimizing the biologic phenotype of engineered vessels. This also provides the framework for testing an array of genes that may improve the function of engineered blood vessels after surgical implantation.
Examining the efficiency of muffle furnace-induced alkaline hydrolysis in determining the titanium content of environmental samples containing engineered titanium dioxide particles (2013)

A novel muffle furnace (MF)-based potassium hydroxide (KOH) fusion digestion technique was developed and evaluated for different titanium dioxide materials in various solid matrices. Digestion of different environmental samples containing sediments, clay minerals and humic acid with and without TiO(2) particles was first performed utilizing the MF-based KOH fusion technique and its dissolution efficacy was compared to a Bunsen burner (BB)-based KOH fusion method. The three types of TiO(2) particles (anatase, brookite and rutile) were then digested with the KOH fusion techniques and microwave (MW)-based nitric (HNO3)–hydrofluoric (HF) mixed acid digestion methods. Statistical analysis of the results revealed that Ti recoveries were comparable for the KOH fusion methods (BB and MF). For pure TiO(2) particles, the measured Ti recoveries compared to calculated values were 96%, 85% and 87% for anatase, brookite and rutile TiO(2) materials, respectively, by the MF-based fusion technique. These recoveries were consistent and less variable than the BB-based fusion technique recoveries of 104%, 97% and 72% and MW-based HNO3–HF mixed acids digestion recoveries of 80%, 81% and 14%, respectively, for anatase, brookite and rutile. Ti percent recoveries and measurement precision decreased for both the BB and MF methods when TiO(2) was spiked into sediment, clay minerals, and humic acid. This drop in efficacy was counteracted by more thorough homogenization of the spiked mixtures and by increasing the mass of KOH in the MF fusion process from 1.6 g to 10.0 g. The MF-based fusion technique is consistently superior in digestion efficiency for all three TiO(2) polymorphs. The MF-based fusion technique required 20 minutes for digestion of 25 samples (based on in-house Lindberg MF capacity) compared to 8 hours for the same number of samples using the BB-based fusion technique. Thus, the MF-based fusion technique can be used to dissolve a large number of samples in a shorter time (e.g., 500 samples per 8 hours) while conserving energy and eliminating health and safety risks from methods involving HF.
Conotoxins and their potential pharmaceutical applications (1999)

The neurotoxins isolated from cone shell venoms are a diverse group of small, disulfide-rich peptides. Most of the active peptides isolated to date have been shown to specifically target various components of neural transmission, and have generally demonstrated high specificities for ion channel and receptor types and subtypes. The specificity of conotoxins is one of the attributes that make them valuable diagnostic tools in the characterisation of neural pathways, as therapeutic agents in medicine, and potentially as biodegradable toxic agents in agroveterinary applications. The number of novel, active peptides within the numerous Conus species is considered to be enormous. Currently, however, relatively few peptides have been characterised. In this article, we review current research on conotoxins with a focus on drug potential being developed at the University of Queensland, Australia. Drug Dev. Res. 46:219–234, 1999. © 1999 Wiley-Liss, Inc.
Efficient tunnel junction contacts for high-power semipolar III-nitride edge-emitting laser diodes (2019)

We demonstrate high-power edge-emitting laser diodes (LDs) with tunnel junction contacts grown by molecular beam epitaxy (MBE). Under pulsed conditions, lower threshold current densities were observed from LDs with MBE-grown tunnel junctions than from similarly fabricated control LDs with ITO contacts. LDs with tunnel junction contacts grown by metal-organic chemical vapor deposition (MOCVD) were additionally demonstrated. These LDs were fabricated using a p-GaN activation scheme utilizing lateral diffusion of hydrogen through the LD ridge sidewalls. Secondary ion mass spectroscopy measurements of the [Si] and [Mg] profiles in the MBE-grown and MOCVD-grown tunnel junctions were conducted to further investigate the results.
WBG inverter for commercial power generation and vehicle electrification (2015)

In recent years, commercially available wide bandgap (WBG) devices and modules have sparked significant interest among several industries to develop power electronics using WBG technology. The commercial viability and benefits of developing such WBG power electronics are visibly increasing. However, there exists a great deal of information disconnect between the WBG semiconductor manufacturers and the end users. Reducing this gap requires immediate attention from all entities in the supply chain of power electronics industry to fully extract the capabilities of WBG technology. This paper introduces the use of power electronics in power generation and vehicle electrification applications. Using examples, potential use of WBG semiconductors in these applications are discussed. Requirements of power semiconductor modules for power electronics applied to power generation and medium- to heavy-duty vehicles are also presented.
Graphene-mediated ferromagnetic coupling in the nickel nano-islands/graphene hybrid (2021)

Nanoscale magnetic structures are fundamental to the design and fabrication of spintronic devices and have exhibited tremendous potential superior to the conventional semiconductor devices. However, most of the magnetic moments in nanostructures are unstable due to size effect, and the possible solution based on exchange coupling between nanomagnetism is still not clear. Here, graphene-mediated exchange coupling between nanomagnets is demonstrated by depositing discrete superparamagnetic Ni nano-islands on single-crystal graphene. The heterostructure exhibits ideal two-dimensional (2D) ferromagnetism with clear hysteresis loops and Curie temperature up to 80 K. The intrinsic ferromagnetism in graphene and antiferromagnetic exchange coupling between graphene and Ni nano-islands are revealed by x-ray magnetic circular dichroism and density functional theory calculations. The artificial 2D ferromagnets constitute a platform to study the coupling mechanism between complex correlated electronic systems and magnetism on the nanoscale, and the results and concept provide insights into the realization of spin manipulation in quantum computing.
Regional myocardial perfusion under exchange transfusion with liposomal hemoglobin: in vivo and in vitro studies using rat hearts (2004)

The purpose of this study was to test the hypothesis that exchange transfusion with liposomal hemoglobin (LH) reduces the microheterogeneity of regional myocardial flows while sustaining cardiac function. Neo Red Cell mixed with albumin was used as the LH solution, in which the LH volume fraction was 17 approximately 18% and hemoglobin density was nearly two-thirds smaller than in rat blood. Regional myocardial flows in left ventricular free walls were measured by tracer digitalradiography (100-mum resolution) in anesthetized rats with or without 50% blood-LH exchange transfusion. Within-layer flow distributions showed lower heterogeneity with (n = 8) than without (n = 8) LH transfusion. No extravasation of hemoglobin was confirmed by 3,3-diaminobenzidin staining (n = 2). Carotid flow increased by 68% due to LH transfusion, whereas arterial pressure and heart rate remained unchanged. On the other hand, cross-circulated rat hearts (n = 7) were used to evaluate the effects of 50% blood-LH exchange on coronary flow and tone preservation under 300-beats/min pacing and 100-mmHg perfusion pressure. Blood-LH exchange caused a 71% increase of coronary flow and 10% decrease of percent flow increase during hyperemia after 30-s flow interruption. Myocardial O(2) supply and consumption increased by 9% and 10%, respectively, whereas myocardial O(2) extraction remained unchanged. The large increases of in vivo carotid flow and coronary flow in cross-circulated hearts due to LH coperfusion could be explained by the reduction of apparent flow viscosity. These results suggest that under LH coperfusion, the microheterogeneity of myocardial flows decreases with increased coronary flow while fairly preserving coronary tone and cardiac function.
Single-shot laser beam profiling using multilevel imaging (Abstract Only) (2003)

We describe a compact laser beam profiler that records multiple images of a laser beam at different positions along the beam waist in a single shot. This is used to determine the laser beam parameter M<sup>2</sup>. It is known that if light is incident on a curved grating such as a section of a Fresnel zone plate, then the +1 and -1 diffracted orders are focused or defocused. By combining two curved gratings and a conventional lens, it is possible to build a system in which a mosaic of nine images are created, corresponding to nine separate object planes. These nine images can be processed and fitted to an appropriate beam profile. This type of system measures beam quality in real time without any moving parts, and has the potential to provide real time monitoring of pulsed lasers, lasers with dynamic spatial behaviour, and in systems where beam handling optics may produce transient aberrations. Unlike other 'single shot' techniques, this technique makes no assumptions about beam propagation, and produces a value of M<sup>2</sup> based only on measurements of beam waists.
Coded matrix computation with gradient coding (2023)

Polynomial based approaches, such as the Mat-Dot and entangled polynomial codes (EPC) have been used extensively within coded matrix computations to obtain schemes with good recovery thresholds. However, these schemes are well-recognized to suffer from poor numerical stability in decoding. Moreover, the encoding process in these schemes involves linearly combining a large number of input submatrices, i.e., the encoding weight is high. For the practically relevant case of sparse input matrices, this can have the undesirable effect of significantly increasing the worker node computation time. In this work, we propose a generalization of the EPC scheme by combining the idea of gradient coding along with the basic EPC encoding. Our technique allows us to reduce the weight of the encoding and arrive at schemes that exhibit much better numerical stability; this is achieved at the expense of a worse threshold. By appropriately setting parameters in our scheme, we recover several well-known schemes in the literature. Simulation results show that our scheme provides excellent numerical stability and fast computation speed (for sparse input matrices) as compared to EPC and Mat-Dot codes.