gebhart/patrepeval huggingface dataset:
Assembling nanoscale quantum photonic devices (Conference Presentation) (2019)

Plasmonic nanostructures made of novel low-loss plasmonic materials are emerging as prime components for single-photon sources and nanoscale sensors with unique properties. Plasmon-enhanced single-photon emitters possess the advantages of GHz photon production rates, nanoscale footprint, room-temperature operation and strong tolerance to the cavity resonance frequency shifts. We present several realizations of quantum emitters coupled to plasmonic nanoantennas made of crystalline silver, using both random and deterministic assembly methods, focusing on single-photon production and the optical readout of single electronic spin states.
<title>Polarimetric impulse response and polarimetric transfer function for time-sequential polarimeters</title> (1990)

An analysis of polarimetric measurements in the presence of noise is presented with emphasis on rotating polarizer polarimeters. A method is presented for estimating the error bars associated with a polarization measurement of an object whose intensity is rapidly fluctuating in a noisy manner. The method requires knowledge of the power spectral density of the intensity fluctuation, and uses this information combined with the sequence of polarizing element settings and measurement times to determine the error bar estimate. The rotating polarizer polarimeter is used as an example of this technique. A relationship is established between the power spectrum of the source intensity fluctuations and the error bars associated with measurements of the Stokes vector elements. The impulse response and transfer function of a polarimetric measurement and data reduction sequence are introduced. The analytical tools presented here will assist in designing polarimeters with specified accuracies for demanding roles, such as measuring polarization signatures in rapidly moving or fluctuating scenarios. It is recommended that for rotating polarizer polarimeters, the polarizer rotates through a minimum of 360o because image nutation from wedged polarizers and linear drift couple strongly into the fundamental frequency of the discrete Fourier transform. The optimum rotating polarizer angle settings for many applications is the eight angle sequence: 0°,45°, 90°, 135°, 180°, 225°, 270°, 315°.
Childhood Caffeine Tic Syndrome (1998)

Our observations suggest that caffeine may precipitate tics in susceptible children.
Recent advances in reconfigurable microwave filter design (2016)

Next-generation multi-mode RF transceivers will require fully-adaptive, high-frequency filtering components with increased levels of spectral agility. Highly-selective single/multi-band filtering actions for various signal-band selection processes and flexible bandstop filtering functions for dynamic interference mitigation will be highly desirable in these systems. Taking into consideration the aforementioned needs, recent advances in the field of adaptive-transfer-function filters are reported in this paper. Specifically, multi-band bandpass filters (BPFs) with tunable passbands, circuits with selectable BPF and bandstop-filter (BSF) operational modes, and broad-band BPFs with incorporated in-band controllable notches are presented.
ChemInform Abstract: Total Synthesis of (+)‐Acutiphycin (I). (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes (2012)

Voltage-gated K(+) channels underlie the electrical excitability of cells. Each subunit of the functional tetramer consists of the tandem fusion of two modules, an N-terminal voltage-sensor and a C-terminal pore. To investigate how sensor coupling to the pore generates voltage-dependent channel opening, we solved the crystal structure and characterized the function of a voltage-gated K(+) channel pore in a lipid membrane. The structure of a functional channel in a membrane environment at 3.1 Å resolution establishes an unprecedented connection between channel structure and function. The structure is unique in delineating an ion-occupied ready to conduct selectivity filter, a confined aqueous cavity, and a closed activation gate, embodying a dynamic entity trapped in an unstable closed state.
Schlüssel zum Öffnen photolabiler, metallhaltiger Käfige (2010)

Abstract Photolabile metallhaltige Käfige sind Metallkomplexe, die bei Bestrahlung mit Licht geeigneter Wellenlänge eine Veränderung der Koordinationsumgebung erfahren. Dabei kann entweder der verkapselnde Ligand allein oder der gesamte Metallkomplex photoresponsiv sein. Die veränderten Koordinationseigenschaften photoresponsiver Komplexe können mehrere Auswirkungen haben: eine Freisetzung des koordinierten Metallions in seine Umgebung, eine veränderte Reaktivität des Metallzentrums oder die Abspaltung eines reaktiven Moleküls, das zuvor durch Bindung an das Metallzentrum passiviert war. Diese photoaktivierbaren Systeme können von Nutzen sein, um die Bioverfügbarkeit von Metallen oder ihren koordinierenden Liganden für das Studium biologischer Reaktionspfade oder für mögliche therapeutische Zwecke zu manipulieren.
T Cell Turnover in SIV Infection (1999)

In their report of 20 February 1998 ([1][1]), H. Mohri et al . analyze the proliferation and death of T cells in normal macaques and in those infected with simian immunodeficiency virus (SIV). With the use of bromodeoxyuridine (BrdU) to label proliferating cells, they observed that the uptake of
Quantification of Macular Blood Flow Volume and Microvascular Network in Multiple Sclerosis (MS) (P2.264) (2014)

Objective: To quantify macular blood flow volume and microvascular network complexity in multiple sclerosis (MS). Background: Diffuse cerebral hypoperfusion in MS have been reported. The vasculature in the eye and cerebral cortex are similar anatomically and physiologically. Retinal periphlebitis are associated with MS. However, retinal microvascular function in MS has not been previously assessed due to the lack of adequate technology. Method: Six healthy subjects and 3 RRMS patients were imaged by Retinal Functional Imager (RFI, Optical Imaging, Rehovot, Israel) in two sessions. Multiple images were performed to calculate the noninvasive capillary perfusion maps (nCPMs). The nCPMs of the macular area consisting of a 2.3 mm diameter circle with the fovea at the center were assessed using fractal analysis. Blood flow velocity maps of the retinal arterioles and venules were determined in all four quadrants. The vessel diameters were measured and the total blood volume of the circular area was calculated. Results: In the healthy group, the mean ± SD blood flow velocities were 4.02 ± 0.48 mm/s (artery) and 3.21 ± 0.56 mm/s (vein). The coefficient of repeatability (CoR) was 0.55 mm/s (CoR%: 17%) and the intraclass correlation coefficient (ICC) was 0.89. The total blood volumes of the circled macular zone were 5.12 ± 1.76 fl/s (artery) and 4.27 ± 0.97 fl/s (vein). Fractal dimension (D0) was 1.762 ± 0.016. CoR was 0.036. In the MS group, the velocities were 2.02 ± 0.56 mm/s (artery) and 1.72 ± 0.39 mm/s (vein). Total blood volumes were 3.2 ± 1.1 fl/s (artery) and 2.8 ± 0.5 fl/s (vein). D0 of the nCPMs was 1.747 ± 0.0007. All measured variables were significantly lower in MS patients than control subjects (P<0.05). Conclusion: This study demonstrates, for the first time to our knowledge, that macular hypoperfusion and decreased nCPMs complexity in MS indicating retinal vascular dysfunction in MS. Grant/financial support: Supported by R01EY020607, NIH R01EY020607S, NIH Center Grant P30 EY014801 and RPB.
Thiol–Ene–Thiol Photofunctionalization of Thiolated Monolayers with Polybutadiene and Functional Thiols, Including Thiolated DNA (2011)

Self-assembly of organic thiols is the most common way to introduce functional groups onto gold surfaces. Although the gold–sulfur (Au–S) bond is moderately strong (∼45 kcal/mol), it is also prone to oxidation, which substantially weakens the Au–S interaction. In this work, we describe the creation of more robust molecular assemblies on gold. As a first step, a thiolated monolayer is prepared on gold with an α,ω-dithiol. Experiments are also reported for a mercaptosilane monolayer on silicon dioxide. An oligomer of polybutadiene (PBd) was then tethered to these surfaces using thiol–ene chemistry. Residual groups on the PBd are then reacted with thiols, including octadecanethiol (ODT), 1H,1H,2H,2H-perfluoroalkanethiol, and a thiol-terminated 25-mer of DNA. Little nonspecific adsorption of a non-thiolated DNA oligomer was observed. Surface characterization was performed with X-ray photoelectron spectroscopy (XPS), contact angle goniometry, time-of-flight secondary ion mass spectrometry (ToF-SIMS), and spectroscopic ellipsometry. A thiol–gold monolayer and an analogous assembly of the same thiol tethered to gold through PBd on a dithiol monolayer were both exposed to air and light for 2 weeks and then rinsed with water. The monolayer on gold was removed in this process, while the thiol in the assembly appeared unaffected.
The Benefits of Reciprocal Mentoring in the Oil and Gas Industry (2018)

Abstract Objective/Scope As the Oil and Gas industry looks for ways to better manage its increasingly age diverse workforce, reciprocal mentoring (RM) has become a necessity. Industry veterans are nearing retirement. Young entrants to the workforce are knowledgeable in technology, but lack industry experience. These two circumstances, along with other factors, helped create the perfect storm – the Great Crew Change. RM can pave the way for a new standard of open dialogue in business, stretching far beyond technology. Ideally, learning and information sharing would cross all lines of seniority and responsibility. Methods, Procedures, Process Everyone knows that mentoring can be useful to a young employee. However, there is a lot that junior employees (millennials) can offer as mentors themselves. Senior employees were trained when technology transfer was slower and less sophisticated. They learned to give presentations without the aid of PowerPoint and other media available today. Often, they relied on a flipchart for a presentation, so they have well developed soft skills and interpersonal skills. Millennials recently graduated, have more experience in technology transfer, and recent applications and technology developed, and are more inclined to communicate through email, text, and social media. RM acts as a powerful tool to help both junior and senior employees strengthen specific skills. Results, Observations, Conclusions Reciprocal mentoring can create dynamic teams utilizing the overall strengths of both millennials and senior employees. These two-way conversations become avenues where employees can discuss insights from both perspectives and gain valuable knowledge from one another in an environment of trust. With the increasing number of Millennials joining the workforce in the oil and gas industry, management must incorporate new ways of mentoring them. The increase in the age gap between senior employees and millennials creates a challenge to keep the workforce engaged. Novel/Additive Information Differences in perspective, attitude towards work and different motivation can result in friction and an unwillingness to collaborate. This is the role of reverse mentoring which is detailed in this paper. With the "Big Crew Change" we are experiencing a shortage of younger more experienced technical professionals. Reciprocal mentoring is a way to bridge that gap.
Providing Enhanced Functionality for Data Store Clients (2017)

Data stores are typically accessed using a clientserver paradigm wherein the client runs as part of an application process which is trying to access the data store. This paper presents the design and implementation of enhanced data store clients having the capability of caching data for reducing the latency for data accesses, encryption for providing confidentiality before sending data to the server, and compression for reducing the size of data sent to the server. We support multiple approaches for caching data as well as multiple different types of caches. We also present a Universal Data Store Manager (UDSM) which allows an application to access multiple different data stores and provides a common interface to each data store. The UDSM provides both synchronous and asynchronous interfaces to each data store that it supports. An asynchronous interface allows an application program to access a data store and continue execution before receiving a response from the data store. The UDSM also can monitor the performance of different data stores. A workload generator allows users to easily determine and compare the performance of different data stores. The paper examines the key design issues in developing both the enhanced data store clients and the UDSM. It also looks at important issues in implementing client-side caching. The enhanced data store clients and UDSM are used to determine the performance of different data stores and to quantify the performance gains that can be achieved via caching.
Hi-C yields chromosome-length scaffolds for a legume genome, Trifolium subterraneum (2018)

Abstract We present a chromosome-length assembly of the genome of subterranean clover, Trifolium subterraneum , a key Australian pasture legume. Specifically, in situ Hi-C data (48X) was used to correct misjoins and anchor, order, and orient scaffolds in a previously published genome assembly (TSUd_r1.1; scaffold N50: 287kb). This resulted in an improved genome assembly (TrSub3; scaffold N50: 56Mb) containing eight chromosome-length scaffolds that span 95% of the sequenced bases in the input assembly.
Virus−Poly(3,4-ethylenedioxythiophene) Composite Films for Impedance-Based Biosensing (2011)

Composite films composed of poly(3,4-ethylenedioxythiophene), PEDOT, and the filamentous virus M13-K07 were prepared by electrooxidation of 3,4-ethylenedioxythiophene (EDOT) in aqueous solutions containing 8 nM of the virus at planar gold electrodes. These films were characterized using atomic force microscopy and scanning electron microscopy. The electrochemical impedance of virus-PEDOT films increases upon exposure to an antibody (p-Ab) that selectively binds to the M13 coat peptide. Exposure to p-Ab causes a shift in both real (Z(RE)) and imaginary (Z(IM)) impedance components across a broad range of frequencies from 50 Hz to 10 kHz. Within a narrower frequency range from 250 Hz to 5 kHz, the increase of the total impedance (Z(total)) with p-Ab concentration conforms to a Langmuir adsorption isotherm over the concentration range from from 6 to 66 nM, yielding a value for K(d) = 16.9 nM at 1000 Hz.
Structural and Spectroscopic Demonstration of Agostic C−C Interactions in Electron-Deficient Metallacyclobutanes and Related Cage Complexes:  Possible Implications for Olefin Polymerizations and Metatheses (2005)

The reaction of the half-open titanocene, Ti(C5H5)(c-C8H11)(PMe3) (c-C8H11 = cyclooctadienyl), with two equivalents of PhC2SiMe3 leads to their incorporation and coupling to the dienyl fragment. One alkyne inserts into a C-H bond of the central CH2 group of the c-C8H11 ligand's edge-bridge, while the second undergoes a 5+2 coupling with the dienyl fragment, yielding coordinated sigma-allyl and olefin fragments, as demonstrated by X-ray diffraction. Together with the C5H5 and PMe3 coordinations, this leads to a 14-electron count. While the very electron-deficient titanium center passes up potential pi coordination of the allyl fragment, it instead engages in interactions with one or two C-C bonds, and perhaps a C-H bond, as revealed from the structural and spectroscopic data. Similar interactions have been found in electron-deficient metallacyclobutane complexes of titanium and zirconium, but not in the 18-electron molybdenum and tungsten analogues. These and other observations may have implications relating to metatheses and polymerizations of olefins.
Preparation and properties of novel aromatic poly(thioethers) derived from 4,4′-thiobisbenzenethiol (1999)

A series of amorphous and semicrystalline aromatic poly(thioethers) have been prepared by the reactions of 4,4′-thiobisbenzenethiol and activated dihalides. Azo group activated dihalide monomer was prepared by the reactions of 4-fluoronitrosobenzene with a suitable diamine. The keto and phosphine sulfide containing monomers were synthesized by Friedel-Crafts acylation reactions of suitable halobenzenes with appropriate acid chlorides. Potassium carbonate mediated reactions in dimethylacetamide afforded moderate to high molecular weight polymers. Polymers with high melting points were prepared by using diphenyl sulfone as a co-solvent. The poly(thioethers) exhibit high glass transition temperatures and/or high melting points. In addition, the polymers exhibit excellent thermal stability.
IL-15 has innate anti-tumor activity independent of NK and CD8 T cells (2010)

The innate immune system is crucial for host defense and immunosurveillance against pathogens and tumor cells. IL-15 is a pleiotropic cytokine with important effects on cells of the innate and adaptive immune systems. The NK cell- and CD8(+) T cell-mediated functions of IL-15 against tumor cells have been well documented. However, it has not been established whether IL-15 has innate anti-tumor functions independent of these cells. Here, we explored the innate anti-tumor potential of IL-15 using a B16F10 melanoma tumor model. IL-15tg mice exhibited significantly more resistance to tumor growth and metastasis compared to B6 mice, and to IL-15(-/-) mice, which exhibited increased susceptibility to B16F10 challenge. In vivo depletion of NK cells and CD8(+) T cells abrogated the innate resistance to B16F10 cells in B6 but not in IL-15tg mice. In addition, lung macrophages from IL-15tg mice produced significantly higher levels of NO and IL-12 compared with macrophages from B6 or IL-15(-/-) mice. To examine whether IL-15 has innate anti-tumor activity independent of NK cells and CD8(+) T cells, we developed Ad-Op-hIL-15; this resulted in significantly higher levels of biologically active hIL-15. Delivery of Ad-Op-hIL-15 into RAG-2(-/-)/gamma(c)(-/-) mice significantly suppressed tumor burden in the lungs compared with the control adenovirus vector. Our results show that IL-15 can have innate anti-tumor activity independent of NK cells and CD8(+) T cells and the common gamma(c)R.
Study on the Mitigation of the Resonance due to the Power-Bus Structure using Periodic Metal-Strip Loaded Sheets (2011)

This paper investigates a method to tackle the resonance problems of the rectangular power-bus structure(PBS) using thin sheets loaded with periodic metal strips. The equivalent surface impedance of the proposed loading is calculated and involved in the expression of the impedance that accounts for in the PBS, in order to improve the resonance behavior of the original structure. The effects of the strips and the immediate surroundings are illustrated by a number of numerical experiments. Also the restrictions of the technique are addressed.
Subclinical cardiotoxicity following adjuvant dose-escalated FEC, high-dose chemotherapy, or CMF in breast cancer (2000)

We compared adjuvant chemotherapy-related myocardial damage by antimyosin scintigraphy in patients who received either nine cycles of FEC (fluorouracil, epirubicin and cyclophosphamide) where the doses of epirubicin and cyclophosphamide were escalated according to the leucocyte nadir (group I, n = 14), three cycles of FEC followed by high-dose chemotherapy with alkylating agents (CTCb) given with the support of peripheral blood stem cell transplantation (group II, n = 14), or six cycles of standard intravenous CMF (cyclophosphamide, methotrexate and fluorouracil; group III, n = 8). The cardiac uptake of In-111-antimyosin-Fab (R11D10) antibody was measured and the heart-to-lung ratio (HLR) calculated 8-36 months after the last dose of chemotherapy. Cardiac antimyosin antibody uptake was considerably higher among patients treated with nine cycles of dose-escalated FEC than among those who were treated with three cycles of FEC and high-dose CTCb (HLR, median 1.98; range 1.36-2.24 vs median 1.51; range 1.20-1.82; P < 0.001), or those treated with CMF (median 1.44; range 1.15-1.68; P < 0.001). The difference between groups II and III was not significant (P > 0.1). A linear association was found between the cumulative dose of epirubicin and the cardiac antimyosin uptake (P < 0.001). We conclude that subclinical cardiac damage caused by three cycles of conventional-dose FEC followed by one cycle of high-dose CTCb chemotherapy is small as compared with the damage caused by dose-escalated FEC.
Genomic Prediction in a Large African Maize Population (2017)

Genomic prediction (GP) combines genomewide marker data with phenotypic data in a training population to predict the genomic estimated breeding values of untested individuals in a relevant testing population. Our objective was to evaluate the effects of population structure, genotype × trial, tester, and management interactions, and imputation methods on the accuracy of GP for grain yield in the CIMMYT's African maize ( Zea mays L.) program. The dataset included 2022 diverse breeding lines in 156 Stage 1 yield trials and 66,000 single‐nucleotide polymorphism markers. The first two principal components from principal component analysis explained 10.5% of the variance in marker data. Based on marker data, five clusters were detected, but cluster of origin explained only 2% of the phenotypic variation. Prediction accuracy, assessed by cross validation, ranged from 0.20 to 0.36 within clusters and from 0.04 to 0.26 across clusters. Mean GP accuracy within clusters (0.27) outperformed pedigree‐based prediction (0.03). Imputation methods did not strongly affect prediction accuracy. Testers and management had large effects. To achieve acceptable GP accuracy within such a diverse population, one can employ (i) a very large training population size, (ii) carefully planned and relevant testers, and (iii) common trial environments and management between the training and validation populations and related genetic materials.
Robust Lateral Control of Heavy Duty Vehicles (2001)

In this report, achievements under MOU385, robust lateral control of heavy vehicles for automated highway systems are presented. The purpose of this project are: to design new controllers or redesign existing controllers for lateral control of heavy vehicles to improve performance; to evaluate designed controllers by experiments and to study autonomous vehicle following control. Toward this goal, we have obtained three main results during year 2000-2001, which are presented in this report.