gebhart/patrepeval huggingface dataset:
Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane (2020)

The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate the antiviral response. Using severe acute respiratory syndrome coronavirus (SARS-CoV) as a model, we demonstrate that SARS-COV ORF6 protein is localized to the endoplasmic reticulum (ER)/Golgi membrane in infected cells, where it binds to and disrupts nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of STAT1 transport into the nucleus in response to interferon signaling, thus blocking the expression of STAT1-activated genes that establish an antiviral state. We mapped the region of ORF6, which binds karyopherin alpha 2, to the C terminus of ORF6 and show that mutations in the C terminus no longer bind karyopherin alpha 2 or block the nuclear import of STAT1. We also show that N-terminal deletions of karyopherin alpha 2 that no longer bind to karyopherin beta 1 still retain ORF6 binding activity but no longer block STAT1 nuclear import. Recombinant SARS-CoV lacking ORF6 did not tether karyopherin alpha 2 to the ER/Golgi membrane and allowed the import of the STAT1 complex into the nucleus. We discuss the likely implications of these data on SARS-CoV replication and pathogenesis.
Body composition and plasma levels of inflammatory biomarkers in COPD (2010)

Previous studies suggest a relationship between systemic inflammation and body composition in chronic obstructive pulmonary disease (COPD). We examined the relationships between body composition (fat free mass index (FFMI) kg·m(-2) and fat mass index (FMI) kg·m(-2)) and three plasma inflammatory markers C-reactive Protein (CRP), soluble tumour necrosis factor receptor 1 (sTNF-R1) and osteoprotegerin (OPG) in 409 stable COPD patients (aged 40-75 yrs, Global Initiative for Obstructive Chronic Lung Disease (GOLD) categories II-IV, 249 male) from the Bergen COPD Cohort Study in Norway. FFMI and FMI were measured by bioelectrical impedance. Plasma CRP (μg·mL(-1)), sTNF-R1 (pg·mL(-1)) and OPG (ng·mL(-1)) were determined by enzyme immunoassays. Correlations and Kruskal-Wallis tests were used for bivariate analyses. Linear regression models were fitted for each of the three markers, CRP, sTNF-R1 and OPG, with FFMI and FMI as explanatory variables including sex, age, smoking habits, GOLD category, hypoxaemia, Charlson Comorbidity Index and inhaled steroid use as potential confounders. CRP and sTNF-R1 levels correlated positively with both FFMI and FMI. The adjusted regression coefficients for an increase in logCRP per unit increase in FFMI was 1.23 (1.14-1.33) kg·m(-2) and 24.9 (11.8-38.1) kg·m(-2) for sTNF-R1. Higher FMI was associated with a lower OPG, with adjusted regression coefficient -0.14 (-0.23- -0.04), whereas FFMI was unrelated to OPG. In conclusion, COPD patients with low FFMI had lower not higher plasma levels of CRP and sTNF-R1, whereas higher fat mass was associated with higher CRP and sTNF-R1 and lower OPG.
Design of a Super Directive Four-Element Compact Antenna Array Using Spherical Wave Expansion (2015)

In this paper, a super directive four-element compact parasitic antenna array has been designed and optimized using an ad hoc procedure based on the Harrington maximum directivity definition and spherical wave expansion. The complete design procedure (i.e., calculation of the optimum excitation coefficients and equivalent impedance loads associated to each parasitic element) is presented and validated through full-wave electromagnetic simulations. The proposed array has been designed at 868 MHz; its electrical size is 0.45λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> × 0.36λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> (diameter of minimum sphere circumscribing the antenna equal to 0.57λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> ). A prototype has been built and tested to demonstrate the effectiveness of this design. A maximum directivity of 11.7 dBi has been measured at 871 MHz in satisfactory agreement with theoretical results and electromagnetic simulations.
Structure and chemistry of the human p300/CBP and yeast Rtt109 histone acetyltransferase (2009)

Histone actyltransferase (HAT) enzymes form a superfamily of proteins that transfer an acetyl group from the acetyl‐coenzyme A (Ac‐CoA) cofactor to the epsilon amino group of histone or sometimes non‐histone proteins to promote gene activation. Paradoxally, despite the similar chemistry carried out by these enzymes, and their structurally related core regions, they fall into subfamilies with very limited to no sequence homology, structurally divergent core flanking regions and they use divergent mechanisms for catalysis. Four well studied HAT families include Gcn5/PCAF, MYST, p300/CBP and Rtt109. Although the structure and chemistry of the evolutionarily conserved Gcn5/PCAF and MYST HATs have been previously characterized, the metazoan‐specific p300/CBP and fungal‐specific Rtt109 have only recently been characterized at the structural and chemical levels. These recent studies provide new insights into the ancestral relationship between HATs and their functions and point to a common HAT ancestor that has evolved around a common structural framework to form HATs with divergent catalytic and substrate binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies will also be discussed.
A Robust System Monitoring and Control for Battery Energy Storage Systems in Electric Vehicle Charging (2023)

This paper presents a System Monitoring and Control (SMC) strategy for battery energy storage systems (BESS) for electric vehicle (EV) chargers and the grid. With an increasing number of EVs, there is a need to handle the great peak demand for EV charging. BESSs provide a fast energy response to charging demands but must have excellent power and energy utilization, battery lifetime, efficiency, and cost. To ensure safety, reliability, and economy, a hierarchical SMC architecture in managing the complexity of a BESS. A prototype design is demonstrated with a hardware implementation and results.
Polymethylmethacrylate (1998)

This book surveys experiences made with Polymethylmethacrylate (PMMA) dialysis membranes, ranging from a summary of the most recent experimental and clinical results to an overview of future potentials and new trends in research. Several articles treat the biophysical properties of the membrane, its chemical structure and manufacturing procedures a
New indole derivatives as potent and selective serotonin uptake inhibitors (1993)

A series of new indole derivatives (2-28) has been prepared in the search for novel 5-HT uptake inhibitors. These compounds were obtained by the condensation of N-(chloroalkyl) naphthalenesultam derivatives with the appropriate amine in presence of a base, at reflux of DMF or THF. The yields were moderate (12-56%), except for the piperazine derivative 20 (85%). The affinity of the compounds for uptake site and 5-HT2, alpha 1, and D2 receptors was measured. Some compounds were studied in vivo by their potentiating effect of 5-HTP-induced symptomatology. The most potent and selective (uptake, 5-HT2 versus alpha 1, D2 sites) compounds contain a 3-[(4-piperidinyl)methyl]indole moiety. 5-Fluoro-3-[(4-piperidinyl)methyl]indole itself (compound 1) displayed a high affinity for the uptake site but was devoided of in vivo activity. N-Methylation of this compound abolished the affinity. In contrast N-substitution by a two-carbon chain linked to a naphthalenesultam or related heterocycle led to compounds exhibiting high affinity for the uptake site. One of them, 1-[2-[4-((5-fluoro-1H-indol-3-yl)methyl-1- piperidinyl]ethyl]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2- ij]quinoline 2,2-dioxide (compound 24), was found as active as fluoxetine in vivo.
Controle De Um Retificador Bidirecional Implementado No Dsp Tms320f2812 - Comparativo Entre As Técnicas De Controle Por Valores Médios E Coordenadas dq0 (2007)

Este artigo apresenta um comparativo entre duas técnicas distintas de controle para o retificador bidirecional com alto fator de potência. A primeira técnica utilizada é a de controle por valores médios clássica. A segunda técnica se baseia na transformação para o sistema de coordenadas dq0. O hardware aplicado aos testes é comum às duas estratégias de controle e o software foi implementado digitalmente no DSP TMS320F2812 da Texas Instruments. Além das técnicas de controle, serão abordadas as diferenças entre a implementação e os resultados obtidos para as metodologias aplicadas.
Single-crystal polarized electronic absorption spectra and ligand field parameters for triphenylphosphine and triphenylarsine in platinum PtCl3L- complexes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSingle-crystal polarized electronic absorption spectra and ligand field parameters for triphenylphosphine and triphenylarsine in platinum PtCl3L- complexesTsu Hsin Chang and Jeffrey I. ZinkCite this: Inorg. Chem. 1986, 25, 16, 2736–2741Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ic00236a017https://doi.org/10.1021/ic00236a017research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nonlinear Dynamics of Electrokinetic Instabilities (2005)

Electrokinetic instabilities are generated by a coupling of electric fields and ionic conductivity gradients. This coupling results in an electric body force in the bulk liquid that can generate temporal, convective, and absolute flow instabilities. In this work, we perform a parametric experimental study of convective instabilities in cross-shaped microchannels using epifluorescence microscopy and high speed digital imaging. We report temporal power spectra and spatiotemporal maps as a function of the applied field. The spectral analyses reveal that disturbances induced by electrokinetic instability are purely sinuous at the onset of instability and exhibit higher-order harmonics, frequency bifurcations, and continuous power spectra with increasing electric Rayleigh number. Electrokinetic instabilities (EKI) in cross-shaped channels are relevant to injections for field amplified sample stacking, electrokinetic flows at the intersections in multi-dimensional assay devices, and systems with indeterminate sample chemistry.Copyright © 2005 by ASME
Ultranarrow Luminescence Linewidth of Silicon Nanocrystals and Influence of Matrix (2014)

The luminescence linewidth of individual silicon nanocrystals was characterized by single-dot spectroscopy, and an ultranarrow linewidth of similar to 200 mu eV at 10 K was found. This value is, in fact, limited by system resolution and represents only the upper limit of the homogeneous linewidth. In addition, the effect of the matrix was investigated for nanocrystals coated with organic ligands, embedded in silicon dioxide, as well as for nanocrystals with only a thin passivating layer. It was found that, depending on the matrix, the room-temperature bandwidth may vary by an order of magnitude, where values as small as similar to 12 meV (similar to 5 nm) at 300 K were detected for nanocrystals with a thin passivation. The observed values for silicon nanocrystals are similar and even surpass some of those for direct-band-gap quantum dots. The narrow linewidth at room temperature enables the use of silicon nanocrystals for nontoxic narrow-band labeling of biomolecules and for application as phosphors in white-light-emitting devices.
USING MULTIPLICITY TO IMPROVE REACTOR PERFORMANCE AND PRODUCT QUALITY IN EMULSION POLYMERIZATION IN CONTINUOUS LOOP REACTORS (2001)

The emulsion copolymerization of vinyl acetate and Veova 10 in a continuous loop reactor was investigated finding that the system presents steady state multiplicity. It is shown how to take advantage of the reactor dynamics to conduct the process in such a way that a pseudo steady state is reached in which high polymerization rates at low temperatures and/or low initiator concentrations are obtained. These conditions allow to achieve high production rate of a high molecular weight polymer which yields high wet scrub resistance. If these conditions were implemented from the beginning of the process, low conversions, and in some cases coagulation, would be obtained.
Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies (2014)

Disturbances of lipid metabolism have been implicated in psychiatric illnesses. We previously reported an association between the gene for fatty acid binding protein 7 (FABP7) and schizophrenia. Furthermore, we identified and reported several rare non-synonymous polymorphisms of the brain-expressed genes FABP3, FABP5 and FABP7 from schizophrenia and autism spectrum disorder (ASD), diseases known to part share genetic architecture. Here, we conducted further studies to better understand the contribution these genes make to the pathogenesis of schizophrenia and ASD. In postmortem brains, we detected altered mRNA expression levels of FABP5 in schizophrenia, and of FABP7 in ASD and altered FABP5 in peripheral lymphocytes. Using a patient cohort, comprehensive mutation screening identified six missense and two frameshift variants from the three FABP genes. The two frameshift proteins, FABP3 E132fs and FABP7 N80fs, formed cellular aggregates and were unstable when expressed in cultured cells. The four missense mutants with predicted possible damaging outcomes showed no changes in intracellular localization. Examining ligand binding properties, FABP7 S86G and FABP7 V126L lost their preference for docosahexaenoic acid to linoleic acid. Finally, mice deficient in Fabp3, Fabp5 and Fabp7 were evaluated in a systematic behavioral test battery. The Fabp3 knockout (KO) mice showed decreased social memory and novelty seeking, and Fabp7 KO mice displayed hyperactive and anxiety-related phenotypes, while Fabp5 KO mice showed no apparent phenotypes. In conclusion, disturbances in brain-expressed FABPs could represent an underlying disease mechanism in a proportion of schizophrenia and ASD sufferers.
Analysis of Key Factors for High Yield AMOLED Display (2015)

To figure out the key factors of the reliability of AMOLED displays, we analyzed the luminance degradation based on a large-scale simulation. The initial non-uniformity and aging parameters were incorporated into the luminance decay model. For each set of parameters, we simulated the luminance degradation of 10,000 panels for 100,000 operating hours and analyzed by two criteria; contrast deviation and luminance variation of panels to determine failures. Stability of TFTs is the most significant parameter for realizing highly reliable AMOLED display. Stability of OLEDs is also potential factor when which of TFTs is sufficient.
New Antihistamines: Substituted Piperazine and Piperidine Derivatives as Novel H1-Antagonists (1995)

Structural manipulation of polycyclic piperazinyl imide serotonergic agents led to the synthesis of compound 8, 2-[4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-4, 4a,5,5a,6,6a-hexahydro-4,6-ethenocycloprop[f]isoindole-1,3(2H,3 aH)-dione, which demonstrated good H1-antagonist activity. Substitution of a xanthinyl moiety for the polycyclic imide group led to the identification of novel xanthinyl-substituted piperazinyl and piperidinyl derivatives with potent antihistamine H1-activity without the undesirable antidopaminergic activity of 8. One compound, 24, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]- 3,7-dihydro-1,3-dimethyl-1H-pyrine-2,6-dione (WY-49051), is a potent, orally active H1-antagonist with a long duration of action and a favorable central nervous system profile.
Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry (2011)

Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor, transferrin receptor 1 (TfR1). TfR1 residues essential for this interaction have been described, and a co-crystal of MACV GP1 bound to TfR1 suggests GP1 residues important for this association. We created MACV GP1 variants and tested their effect on TfR1 binding and virus entry to evaluate the functional significance of some of these and additional residues in human and simian cells. We found residues R111, D123, Y122, and F226 to be essential, D155, and P160 important, and D114, S116, D140, and K169 expendable for the GP1-TfR1 interaction and MACV entry. Several MACV GP1 residues that are critical for the interaction with TfR1 are conserved among other New World arenaviruses, indicating a common basis of receptor interaction. Our findings also open avenues for the rational development of viral entry inhibitors.
Mapping the Lectin-Like Activity of Tumor Necrosis Factor (1994)

Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian trypanosomes. This activity was not blocked by soluble 55-kilodalton and 75-kilodalton TNF receptors, but was potently inhibited by N,N'-diacetylchitobiose, an oligosaccharide that binds TNF. Comparative sequence analysis of TNF and LT localized the trypanocidal region, and synthetic peptides were trypanolytic. TNF molecules in which the trypanocidal region was mutated or deleted retained tumoricidal activity. Thus, trypanosome-TNF interactions occur via a TNF domain, probably with lectin-like affinity, which is functionally and spatially distinct from the mammalian TNF receptor binding sites.
Hybrid access networks integrated with wireline and wireless services without optical filtering at remote nodes (2008)

A multi-services hybrid access network has been experimentally demonstrated. The scheme has no RF fading issue; can carry vector signals, and requires no optical filter at remote nodes.
A permalloy current sensor (1976)

The design, fabrication and output characteristics of a thin film Permalloy magnetoresistive magnetic field sensor in a balanced bridge configuration are described. The bridge elements consist of two magnetostatically coupled Permalloy films (100 to 500 A°) separated by a thin film titanium spacer (100 to 1,000 A°). When this bridge is integrated with electrically isolated overlay conductors, the resulting device is ideally suited to sense currents in power supply applications over a 0 to 100 MHz frequency range with negligible dc offset. Devices with 35 mV peak outputs optimized to sense 50, 250 and 500 mA peak currents have been implemented and tested.
Spatiotemporal distribution of white matter lesions in relapsing–remitting and secondary progressive multiple sclerosis (2012)

The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.
ChemInform Abstract: An Efficient Synthesis of 2‐Nitropyrrole‐3,4‐dicarboxamide. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A design method for bending-insensitive single-mode holey fibers (2005)

We propose a novel design method for bending-insensitive single-mode holey fibers with a mode field diameter of 9 /spl mu/m, a small allowable bending radius of 6.4 mm, and a cutoff wavelength of 1.24 /spl mu/m.
Preparation of NdBa2Cu3O7−δ films in ultrahigh vacuum with a NO2 supersonic molecular beam (1990)

Superconducting NdBa2Cu3O7−δ thin films have been prepared in ultrahigh vacuum by the molecular beam epitaxy (MBE) method using a supersonic molecular beam of nitrogen dioxide as an oxidizing agent. A new type of supersonic molecular beam source has been developed, which has a liquid nitrogen trap for cryogenic pumping and is small enough in size to be installed in a conventional MBE system. Films with a transition temperature of about 30 K have been obtained in situ without post-deposition annealing. Throughout deposition epitaxial growth of the films was observed in situ by reflection high-energy electron diffraction.
Insights into CD24 and Exosome Physiology and Potential Role in View of Recent Advances in COVID-19 Therapeutics: A Narrative Review (2022)

Cluster of differentiation (CD) 24, a long-known protein with multifaceted functions, has gained attention as a possible treatment for Coronavirus Disease 19 (COVID-19) due to its known anti-inflammatory action. Extracellular vesicles (EVs), such as exosomes and microvesicles, may serve as candidate drug delivery platforms for novel therapeutic approaches in COVID-19 and various other diseases due to their unique characteristics. In the current review, we describe the physiology of CD24 and EVs and try to elucidate their role, both independently and as a combination, in COVID-19 therapeutics. CD24 may act as an important immune regulator in diseases with complex physiologies characterized by excessive inflammation. Very recent data outline a possible therapeutic role not only in COVID-19 but also in other similar disease states, e.g., acute respiratory distress syndrome (ARDS) and sepsis where immune dysregulation plays a key pathophysiologic role. On the other hand, CD24, as well as other therapeutic molecules, can be administered with the use of exosomes, exploiting their unique characteristics to create a novel drug delivery platform as outlined in recent clinical efforts. The implications for human therapeutics in general are huge with regard to pharmacodynamics, pharmacokinetics, safety, and efficacy that will be further elucidated in future randomized controlled trials (RCTs).
Editorial Comment (1989)

No AccessJournal of Urology1 Dec 1989Editorial Comment Glenn M. Preminger Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39147-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 142(6), p. 1524 © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 142Issue 6December 1989Page: 1524 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Glenn M. Preminger More articles by this author Expand All Advertisement PDF DownloadLoading ...