gebhart/patrepeval huggingface dataset:
Effect of 12 Weeks of Wrist and Forearm Training on High School Baseball Players (2004)

Szymanski, D.J., J.M. Szymanski, J.M. Molloy, and D.D. Pascoe. Effect of 12 weeks of wrist and forearm training on high school baseball players. J. Strength Cond. Res. 18(3):432–440. 2004.—This study examined the effect of 12 weeks of wrist and forearm training on male high school baseball players (mean age = 15.3 ± 1.1 years). Participants (N = 43) were tested for 10 repetition maximum (RM) wrist barbell flexion, wrist barbell extension, dominant (D) and nondominant (ND) hand-forearm supination, D and ND forearm pronation, D and ND wrist radial deviation, D and ND wrist ulnar deviation, D and ND grip strength, and a 3RM parallel squat (PS) and bench press (BP). Group 1 (n = 23) and group 2 (n = 20), randomly assigned by a stratified sampling technique, performed the same resistance exercises while training 3 days a week for 12 weeks according to a stepwise periodized model. Group 2 also performed wrist and forearm exercises 3 days a week for 12 weeks to determine if additional wrist and forearm training provided further wrist and forearm strength improvements. All wrist and forearm strength variables were measured before and after 12 weeks of training. The 3RM PS and BP were measured at 0 and after 4, 8, and 12 weeks of training. Both groups significantly increased wrist and forearm strength (kg ± SD) except 10RM D and ND forearm supination for group 1 (p < 0.05). Group 2 showed statistically greater improvements (p < 0.05) in all wrist and forearm strength variables than did group 1 except for D and ND grip strength. Predicted 1RM (kg ± SD) PS and BP increased significantly (p < 0.05) after weeks 4, 8, and 12 for both groups. These data indicate that a 12-week stepwise periodized training program can significantly increase wrist, forearm, PS, and BP strength for both groups. Additionally, group 2 had further wrist and forearm strength gains.
Accurate Active Device Characterization for a 60GHz 65nm-CMOS Power Amplifier Realization (2010)

International audience
Path loss prediction model for 800 MHz to 37 GHz in NLOS microcell environment (2015)

Fifth generation (5G) mobile communication systems are being actively investigated to increase the system capacity. For 5G, utilizing frequency bands above 6 GHz is being investigated because it is considered that ensuring a wide frequency band above 6 GHz is relatively easier than that under 6 GHz, which is used for IMT-Advanced systems. In this report, a site general type path loss prediction model for 5G system radio link design is investigated for the above mentioned frequency band in a non-line-of-sight (NLOS) microcell environment. More specifically, based on measurement data, extending the applicable frequency range of the path loss prediction model for a hexagonal layout in a NLOS microcell environment for under 6 GHz, which is defined in Report ITU-R M.2135, is investigated. The root mean square of the prediction error (RMSE) of the original M.2135 prediction model increases with an increase in frequency; however, the model modifies the frequency term of M.2135 which improves the RMSE at higher frequencies.
Clouseau: Generating Communication Protocols from Commitments (2020)

Engineering a decentralized multiagent system (MAS) requires realizing interactions modeled as a communication protocol between autonomous agents. We contribute Clouseau, an approach that takes a commitment-based specification of an interaction and generates a communication protocol amenable to decentralized enactment. We show that the generated protocol is (1) correct—realizes all and only the computations that satisfy the input specification; (2) safe—ensures the agents' local views remain consistent; and (3) live—ensures the agents can proceed to completion.
Experimental study of the scattered near field of submerged objects with surface impedance discontinuties (1994)

The extreme near field of several targets that incorporated abrupt surface impedance discontinuities was measured in the frequency range of 5 to 40 kHz using a medical ultrasound probe as a miniature hydrophone. The probe was mounted in an automated positioning system designed specifically for this application. Although it incorporated a relatively insensitive hydrophone and a weak source, the measurement system exhibited adequate dynamic range (on the order of 80 dB) for this experiment. Targets were acoustically large with ka in the range of 1 to 10 in the measurement frequency range. Insonifying signals were narrow band and virtually plane wave. Cylindrical, spherical, and planar targets were studied. Measurements were made of total surface pressure and pressure gradient on both uniform and mixed boundary objects. High wave-number standing waves were observed in the region of the discontinuities. Good agreement with both three-dimensional boundary element and two-dimensional collocation theory was observed at the low end of the frequency range. Issues of hardware design, signal processing, hydrophone–surface separation, accuracy of positioning, and spatial resolution will be discussed in addition to a qualitative analysis of data in the light of previous modeling efforts. [Work supported by ONR.]
Identification of a homozygous recessive variant in <i>PTGS1</i> resulting in a congenital aspirin-like defect in platelet function (2020)

We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the homozygous state within a large consanguineous family this variant is associated with a bleeding phenotype and alterations in platelet reactivity and eicosanoid production. Western blotting and confocal imaging demonstrated that COX-1 was absent in the platelets of three family members homozygous for the PTGS1 variant but present in their leukocytes. Platelet reactivity, as assessed by aggregometry, lumi-aggregometry and flow cytometry, was impaired in homozygous family members, as were platelet adhesion and spreading. The productions of COX-derived eicosanoids by stimulated platelets were greatly reduced but there were no changes in the levels of urinary metabolites of COX-derived eicosanoids. The proband exhibited additional defects in platelet aggregation and spreading which may explain why her bleeding phenotype was slightly more severe than those of other homozygous affected relatives. This is the first demonstration in humans of the specific loss of platelet COX-1 activity and provides insight into its consequences for platelet function and eicosanoid metabolism. Notably despite the absence of thromboxane A2 (TXA2) formation by platelets, urinary TXA2 metabolites were in the normal range indicating these cannot be assumed as markers of in vivo platelet function. Results from this study are important benchmarks for the effects of aspirin upon platelet COX-1, platelet function and eicosanoid production as they define selective platelet COX-1 ablation within humans.
Systematic surgical closure of patent foramen ovale in selected patients with cerebrovascular events due to paradoxical embolism. Early results of a preliminary study, (1997)

OBJECTIVE: To define therapeutic strategy for management of patients with ischemic stroke due to a high probability of paradoxical embolism through a Patent Foramen Ovale (PFO). METHODS: Since 1988 all consecutive patients with cerebrovascular events and PFO from the Stroke Registry of our population-based primary-care center are prospectively studied and followed. Since 1992, among 118 patients with cryptogenic embolic brain infarct or transient ischemic attack (TIA) and PFO, 32 consecutive patients younger than 60 years who presented at least two of the following criteria were admitted for surgery: history of Valsalva strain before stroke (11); multiple clinical events (13); multiple infarcts on brain Magnetic Resonance Imaging (MRI) (15); atrial septal aneurysm (ASA) (16); large right-to-left shunt (&gt; 50 microbubbles) (12). RESULTS: Operative time 135' +/- 33'. CPB time 34' +/- 14'. Aortic crossclamping time 16' +/- 6'. Post-operative bleeding 485 +/- 170 ml. No homologous blood transfusion required. No neurological, cardiac or renal complications. All patients were followed-up corresponding to a cumulative time of 601 patient-months. This revealed no recurrent vascular events nor silent new brain lesions on brain MRI. Systematic simultaneous contrast Trans Esophageal Echocardiography (TEE)-Trans Cranial Doppler showed a small residual interatrial shunt in two patients. CONCLUSION: Surgical closure of a patent foramen ovale can be accomplished with very low morbidity and reduce efficiently the risk of stroke recurrence. It seems to be the option of choice in selected patients with a higher (&gt; 1.5%/year) risk of stroke recurrence.
Highly unsaturated phosphorus compounds: Trimeric and dimeric sulfides of a α,β‐di‐tert‐butyl vinyl phosphaalkyne (2010)

Abstract The first examples of sulfides of a 1,3,5‐triphosphabenzene were synthesized by the sulfurization of parent 1,3,5‐triphosphabenzene 2 . Disulfide 7 was found to be remarkably thermally stable, the stability likely coming from the contribution of resonance forms 7A and 7B . In addition to two hydrolysis products of trisulfide 8 , which can be anticipated in unsaturated phosphorus chemistry, a new and not trivial bicyclic bridgehead five‐membered heterocycle 10 was isolated among the decomposition products of 8 . © 2010 Wiley Periodicals, Inc. Heteroatom Chem 22:114–118, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20664
ChemInform Abstract: Asymmetric Catalysis. Part 52. Rhodium‐Catalyzed Enantioselective Transfer Hydrogenation of C=C Double Bonds with the System HCOOH/Et3N as Hydrogen Source. (1990)

Abstract The title hydrogenation reaction is successfully applied to α,β‐unsaturated compounds, e.g. (I) and (III).
High‐throughput screening for Plasmodium falciparum glucose‐6‐phosphate dehydrogenase‐6‐phosphogluconolactonase inhibitors (2012)

During malaria infections, there is a significant increase in the pentose phosphate pathway activity of Plasmodium falciparum (1). In addition, its key enzyme, glucose‐6‐phosphate dehydrogenase‐6‐phosphogluconolactonase (PfGluPho), shows structural differences to the human enzyme, thus making PfGluPho an ideal target for antimalarial drug design (2). Recent cloning and overexpression (2) of recombinant PfGluPho allowed investigations in a high throughput format. We were able to develop a high‐throughput screening assay to identify inhibitors for PfGluPho. Three small molecule compound libraries were screened, namely LOPAC™ (Sigma‐Aldrich, 1,280 compounds), Spectrum™ (Microsource discovery system, ~2,000 compounds), and DIVERSet™ (ChemBridge, ~50,000 compounds), which resulted in ~900 compounds that inhibited PfGluPho activity for at least 50%. Selected compounds were subjected to follow‐up studies, including IC 50 determination and mechanistic characterization. The availability of recombinant PfGluPho, its major differences to human G6PD, and the identified inhibitors facilitate further studies on PfGluPho as excellent drug target candidates for the search of new antimalarial drugs. Supported by NIH 1R21AI082434‐01
Efficient Pd(0)‐Catalyzed Synthesis of 1,2,3‐Triazolo‐3′‐deoxycarbanucleosides and Their Analogues. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Manipulating Higher Order Chromatin Structure of the β-Globin Locus by Targeted Tethering of a “looping” Factor (2010)

Abstract Abstract 647 The mammalian β-globin locus is under the coordinated control of multiple transcription factors to ensure the correct expression of the globin genes during development. The distal β-globin locus control region (LCR) physically interacts with β-like globin promoters to form developmentally dynamic chromatin loops. The hematopoietic transcription factor GATA-1 and its associated cofactor Ldb1 bind to the LCR and the β-globin promoter and are essential for loop formation and β-globin expression. However, the molecular basis of chromatin looping and its cause-effect relationship with transcriptional activation are unclear. Here, we examined whether Ldb1 is an effector of GATA-1 during loop formation. Specifically, we tested whether artificial tethering of Ldb1 to the endogenous β-globin promoter and LCR can substitute for GATA-1 function. Ldb1 was fused to artificial zinc finger proteins (ZFP) designed to bind to the LCR and β-globin promoter. Ldb1-ZFPs were introduced pairwise into murine GATA-1 null erythroid cells in which the β-globin locus is relaxed and transcriptionally silent. In vivo binding of the Ldb1-ZFPs to their targets was verified by ChIP assay. Strikingly, expression of Ldb1-ZFPs but not Ldb1 or ZFPs alone led to substantial activation of β-globin transcription in the absence of GATA-1. Moreover, chromosome conformation capture experiments showed that Ldb1-ZFPs triggered physical association between the LCR and the β-globin promoter. Recruitment of RNA polymerase II (Pol II) and its phosphorylation at serine 5 are critical LCR-dependent regulatory steps in β-globin transcription. We found that Ldb1-ZFP expression facilitated Pol II recruitment at the β-globin promoter and serine 5 phosphorylation to the same level as GATA-1-expressing erythroid cells. This is consistent with an Ldb1-ZFP-induced LCR-β-globin promoter chromatin loop. In concert, these results indicate that Ldb1 is a critical effector for GATA-1 by mediating enhancer-promoter loops. In broader terms, our results suggest that chromatin loop formation can be sufficient for gene activation in the absence of an essential transcription factor. We are currently in the process of examining whether targeting of the LCR to embryonic and fetal globin genes can be used to activate them in adult cells. Targeted chromatin loop formation may provide a method to activate fetal or adult hemoglobin expression in individuals with β-thalassemia or sickle cell anemia. Disclosures: No relevant conflicts of interest to declare.
Comparison of Quadriceps Angle Measurements Using Short‐Arm and Long‐Arm Goniometers: Correlation With MRI (2011)

The results of this study suggest that, although reproducible Q-angle measurements can be performed using standardized patient positioning and a long-arm goniometer, methods to improve the accuracy of clinical Q-angle measurements are needed.
Self-Assembly of Molecular Graphenes into Graphite Nanotubes (2009)

This review article gives an overview of our recent discovery that a Gemini-shaped hexa-peri-hexabenzocoronene (HBC) amphiphile (1) and its derivatives undergo highly controlled self-assembly to form a new family of nanotubes that may be called ‘graphite’ nanotubes. Compound 1 possesses hydrophilic triethylene glycol (TEG) chains on one side of the HBC core and hydrophobic dodecyl side chains on the other. The nanotubes are characterized by uniform diameter and wall thickness, a large aspect ratio, and designable inner and outer surfaces. Furthermore, they possess a helical chirality. In fact, under certain conditions, a coiled assembly, which is a kinetically preferred product, is formed temporarily and then transforms, on annealing, into a tubular assembly. Furthermore, HBC derivatives bearing a stereogenic center can form coiled and tubular assemblies with a one-handed helical chirality. Analogous to compound 1, HBC amphiphiles carrying functional groups at the TEG termini self-assemble in a highly controlled manner, affording surface-functional nanotubes. As one of the ideal designs for photovoltaic materials with a nanometric size regime, photoconductive nanotubes with a coaxial configuration of the donor/acceptor heterojunction is highlighted.
Molecular Gas Adsorption Induced Carrier Transport Studies of Epitaxial Graphene Using IR Reflection Spectroscopy (2012)

We investigate molecular adsorption doping by electron withdrawing NO2 and electron donating NH3 on epitaxial graphene. Amperometric measurements show conductance changes upon introduction of molecular adsorbents on epitaxial graphene. Conductance changes are a trade-off between carrier concentration and scattering, and manifest at direct current and optical frequencies. We therefore investigate changes in the infrared (IR) reflection spectra to correlate these two frequency domains, as reflectance changes are due to a change of EG surface conductance. We match theory with experimental IR data and extract changes in carrier concentration and scattering due to gas adsorption. Finally, we separate the intraband and interband scattering contributions to the electronic transport under gas adsorption. The results indicate that, under gas adsorption, the influence of interband scattering cannot be neglected, even at DC.
Exploring the Optical Properties of Picture Varnishes Using Imaging Techniques (2003)

An experimental paradigm was developed in which a varnished painting was considered as ani111aging system such as a camera: the unvarnished painting was equivalent to a scene, the varnish was equivalent to an optical system, and the observer was equivalent to the sensor of the camera. Methodologies used to evaluate image quality were employed to evaluate the quality changes that occur when a varnish is applied. An unvarnished painting was simulated by a photographic transparency in physical contact with triple-thickness window glass sandblasted on one side. Varnish resins applied to the sandblasted surface simulated a varnished paint surface. Back-illuminated images transmitted through the varnished glass were digitized using a near-colorimetricdigital camera. Differences in physical. properties between varnish resins would result in changes in image quality. These were quantified by spatial analyses (using a modulation transferfunction), colorimetricanalyses, and visualization using a reproduction of an Old Master painting. The results confirmed the utility of this approach to quantifying the effects of varnishing on the appearance if paintings.
A current flow controller for use in HVDC grids (2012)

Early proposals for multi-terminal HVDC interconnections have been predominantly radial type connections, that is, between any two nodes there is only one branch. However, plans for `HVDC Grids&apos; in the not too distant future are, or include, meshed sections where there are parallel branches between nodes in the HVDC Grid. In such meshed HVDC Grid the DC current will inherently flow from one node to another via the path of least resistance. However, this may mean that one branch within the HVDC Grid becomes overloaded, hence, power flows across the HVDC Grid may have be constrained in order to keep all branch loadings within their rating. In order to avoid the need to apply constraints a number of solutions have been proposed to date and these are discussed here. (5 pages)
<title>Measurement and analysis of scatter from silicon wafers</title> (1994)

The measurement of wafer surface roughness has become of increasing interest in the semiconductor industry in the last year. This interest is driven by the need to reduce background `haze' associated with laser scanning particle counters, by the ever decreasing linewidth requirements and by a recent report that gate oxide breakdown voltage decreases as roughness increases. Scatter measurement offers the potential of being a fast, non-contact method of monitoring roughness; however, the ability to accurately calculate wafer roughness via scatter depends on various wafer surface characteristics. The paper presents data taken on a number of wafers and demonstrates that bare silicon scatters almost exclusively from surface topography and is isotropic over an appropriate spatial bandwidth, thus facilitating scatter measurement. Because silicon proved to be an excellent source of topographic scatter, an experiment was undertaken to compare the one dimensional roughness measurements made with an optical profilometer to the two dimensional (area) measurements made via scatter, and these results are also reported.
Effects of Anti-Fatigue Mats on Perceived Discomfort and Weight-Shifting During Prolonged Standing (2012)

These results suggest that subjective reports of discomfort were not sufficiently sensitive to detect differences among mats for the experimental conditions tested. Behavioral responses, specifically weight-shifting between feet, may provide a more sensitive alternative to subjective reports.
Abstract A259: Characterization of next generation (Gen2.5) KRAS antisense inhibitors in NSCLC, PDAC, and CRC models. (2013)

Abstract KRAS is among the first described oncogenes and one of the most frequently mutated genes in human solid tumors. Despite substantial efforts to identify specific KRAS inhibitors, no effective therapeutic strategies to target KRAS directly have been identified. Here we describe the selective inhibition of KRAS with next generation (Gen2.5) antisense oligonucleotides. We recently demonstrated preclinical and clinical activity of a next-generation constrained-ethyl (cEt) modified (Gen 2.5) antisense oligonucleotides (ASOs) targeting STAT3 mRNA (STAT3Rx/AZD9150). Systemic delivery of unformulated STAT3Rx/AZD9150 produced robust target RNA and protein reductions in a broad range of xenograft models (AACR 2013). More importantly, STAT3Rx/AZD9150 showed striking clinical activity in the phase I dose escalation study, producing anti-tumor activity in 4 out of 6 patients with advanced treatment-refractory lymphoma (ASCO 2013). In this study, we generated a panel of high affinity Gen2.5 ASO targeting KRAS. Anti-proliferative effects of the KRAS ASOs were evaluated on a panel of colorectal carcinoma (CRC), non-small cell lung carcinoma (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) cell lines. KRAS ASOs potently and selectively inhibited growth of KRAS mutant CRC lines but did not affect the growth of KRAS WT CRC cells in 2D growth assays. Evaluation of KRAS depletion in NSCLC and PDAC lines revealed that sensitivity of these lines to growth inhibition in 2D assays required mutant KRAS status and the presence of a previously described “KRAS addiction” gene expression signature (Singh et al 2009). Surprisingly, further evaluation of KRAS ASO mediated depletion of NSCLC and PDAC lines in 3D growth assays (e.g. soft agar colony formation and polystyrene sponge (Alvetex)) resulted in strong inhibition of colony formation in all mutant KRAS lines, but not WT KRAS lines, and the sensitivity to KRAS depletion was independent of the expression of the “KRAS addiction” signature. Collectively, we have shown that KRAS mutational status confers specific sensitivity to the ASO-mediated KRAS knockdown (KRAS oncogene addiction). Our data also highlights that antisense-mediated inhibition of KRAS may represent a promising and translatable approach to target KRAS therapeutically. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A259. Citation Format: Alexey S. Revenko, Gourab Bhattachrjee, Chris May, Brett P. Monia, A. Robert MacLeod. Characterization of next generation (Gen2.5) KRAS antisense inhibitors in NSCLC, PDAC, and CRC models. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A259.
Supplementary Table S4 from Sex Differences in Cancer Driver Genes and Biomarkers (2023)

&lt;p&gt;All copy number gain results&lt;/p&gt;