gebhart/patrepeval huggingface dataset:
The Epstein‐Barr Virus (EBV) major envelope glycoprotein gp350/220‐specific antibody reactivities in the sera of patients with different EBV‐associated diseases (1998)

gp350 of Epstein-Barr virus (EBV) induces a strong immune response in EBV-infected individuals, but relatively little is known about the clinical relevance of this response in patients with different EBV-associated malignancies and other diseases.Using our gp350-expressing cell clones, we studied gp350-specific humoral immune responses in the sera of individuals with nasopharyngeal carcinoma (NPC), chronic symptomatic EBV infection (CEI), Hodgkin's disease (HD), acute infectious mononucleosis (IM) and healthy EBVseropositive individuals (HI).The titres of antibody-dependent cellular cytotoxicity (ADCC) antibodies were highest in HI followed by CEI, HD and NPC.EBV-neutralizing (NA) and gp350-specific IgG antibody profiles in these conditions were: CEI G HI G NPC G HD, whereas IgA titres were the highest in NPC sera followed by CEI and HD.The sera from IM patients were found to be negative for gp350-specific ADCC and IgA activities.Sera from HI were also negative for gp350-specific IgA.A significant positive correlation was found between serum gp350 IgA and viral capsid antigen IgA and a significant negative one between IgM and ADCC titres.High IgA titres were also found in CEI and EBV-genome positive HD in addition to NPC.Importantly, gp350-specific IgA titres were of prognostic value in NPC patients.Our data provide new insights about the clinical relevance of gp350specific immune responses in these diseases.
Mid-Wave Infrared Quantum Dot Light Emitting Diodes (2020)

We present the design, growth, fabrication, and characterization of type-II quantum-dot (QD) based light emitting diodes (LEDs) mid-wave infrared wavelengths. We demonstrate promising temperature performance for the QD-LEDS and as their incorporation into monolithic plasmonic cavities. The potential for individual quantum emitter devices is discussed.
BaSrTiO nanoparticles dispersion for 3D integration of decoupling capacitors on glass interposer (2016)

International audience
Around the world: status and prospects with the infrared vortex coronagraph (Conference Presentation) (2018)

Since its first light at the VLT in 2012, the Annular Groove Phase Mask (AGPM) has been used to implement vortex coronagraphy into AO-assisted infrared cameras at two additional world-leading observatories: the Keck Observatory and the LBT. In this paper, we review the status of these endeavors, and briefly highlight the main scientific results obtained so far. We explore the performance of the AGPM vortex coronagraph as a function of instrumental constraints, and identify the main limitations to the sensitivity to faint, off-axis companions in high-contrast imaging. These limitations include the AGPM itself, non-common path aberrations, as well as the data processing pipeline; we briefly describe our on-going efforts to further improve these various aspects. Based on the lessons learned from the first five years of on-sky exploitation of the AGPM, we are now preparing its implementation in a new generation of high-contrast imaging instruments. We detail the specificities of these instruments, and how they will enable the full potential of vortex coronagraphy to be unleashed in the future. In particular, we explain how the AGPM will be used to hunt for planets in the habitable zone of alpha Centauri A and B with a refurbished, AO-assisted version of the VISIR mid-infrared camera at the VLT (aka the NEAR project), and how this project paves the way towards mid-infrared coronagraphy on the ELT with the METIS instrument. We also discuss future LM-band applications of the AGPM with VLT/ERIS, ELT/METIS, and with a proposed upgrade of Keck/NIRC2, as well as future applications at shorter wavelengths, such as a possible upgrade of VLT/SPHERE with a K-band AGPM.
Multi-Sensory Stimuli Improve Distinguishability of Cutaneous Haptic Cues (2019)

Wearable haptic systems offer portable, private tactile communication to a human user. To date, advances in wearable haptic devices have typically focused on the optimization of haptic cue transmission using a single modality, or have combined two types of cutaneous feedbacks, each mapped to a particular parameter of the task. Alternatively, researchers have employed arrays of haptic tactile actuators to maximize information throughput to a user. However, when large cue sets are to be transmitted, such as those required to communicate language, perceptual interference between transmitted cues can decrease the efficacy of single-sensory systems, or require large footprints to ensure salient spatiotemporal cues are rendered to the user. In this paper, we present a wearable, multi-sensory haptic feedback system, MISSIVE (Multi-sensory Interface of Stretch, Squeeze, and Integrated Vibration Elements), that conveys multi-sensory haptic cues to the user's upper arm. We present experimental results that demonstrate that rendering haptic cues with multi-sensory components-specifically, lateral skin stretch, radial squeeze, and vibrotactile stimuli-improved perceptual distinguishability in comparison to similar cues with all-vibrotactile components. These results support the incorporation of diverse stimuli, both vibrotactile and nonvibrotactile, for applications requiring large haptic cue sets.
Cracking of Ti2AlNb-based alloy after laser beam welding (2021)

Abstract Crack formation process in the Ti-23Al-23Nb-1.4V-0.8Zr-0.4Mo-0.4Si (at.%) alloy based on orthorhombic titanium aluminide (Ti 2 AlNb), especially in the weld zone (WZ), heat-affected zone (HAZ), and base metal (BM), during laser beam welding (LBW) at room temperature was considered. It was determined that the crack spread in the WZ throughout the crystallites of β-phase. In the HAZ, cracks spread throughout the globular β-phase crystals body and along the edges of globular α 2 - and O-phases. The cracking stopped in BM due to a mechanism similar to shear ligament toughening. Cracking can be effectively suppressed by increasing the LBW temperature.
ChemInform Abstract: ASYMMETRIC SYNTHESES VIA HETEROCYCLIC INTERMEDIATES ‐ XXII. ENANTIOSELECTIVE SYNTHESIS OF α‐ALKENYLGLYCINE METHYL ESTERS AND α‐ALKENYLGLYCINES (β,Γ‐UNSATURATED AMINO ACIDS) (1984)

Abstract Ausgehend vom Bis‐lactimether (I) werden mit den Aldehyden (II) dieAdditionsprodukte (IV) dargestellt, von denen (IVa), (IVb) durch SäurehYdrolyse I" (V)] und nachfolgende Eliminierungsreaktion die (R)‐Alkenylglycine (VII) [(VIIb) = l :l‐E/ Z‐Gemisch] liefern.
Hydrogen Sensing with Diameter- and Chirality-Sorted Carbon Nanotubes (2011)

The work function of palladium is known to be sensitive to hydrogen by the formation of a surface dipole layer or Pd hydride. One approach to detect such a change in the work function can be based on the formation of a Schottky barrier between the palladium metal and a semiconductor. Here, we study the hydrogen sensitivity of Schottky barrier field-effect transistors made for the first time from diameter- and chirality-sorted semiconducting single-walled carbon nanotubes (s-SWNTs) in contact with Pd electrodes. We observe an unrivaled 100-fold change in the on-state conductance at 100 ppm H2 compared to air for devices with s-SWNT and diameters between 1 and 1.6 nm. Hydrogen sensing is not observed for devices of Pd-contacted few-layer graphene (FLG), as expected due to the absence of a significant Schottky barrier. Unexpectedly, we observe also a vanishing sensitivity for small-diameter SWNTs. We explain this observation by changes in the nanotube work function caused by spillover and chemisorption of atomic hydrogen onto small-diameter nanotubes. We also observe that long-term sensing stability is only achieved if the gate voltage is inverted periodically. Under constant gate bias, the sensitivity reduces with time, which we relate to gate screening by accumulated charges in the substrate.
Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod (2012)

A 50-year-old man with multiple sclerosis (MS) was admitted with a seizure and coma in the setting of herpes zoster. The patient developed MS in 2003 and was switched to fingolimod in 2011, 4 months after discontinuing natalizumab (54 doses). He was clinically stable, but mostly wheelchair-bound
An extrapolation technique for predicting the radiation pattern of antennas and arrays located on large structures (2002)

Despite the tremendous progress in numerical techniques for solving the problems of radiation and scattering from antennas located on large structures, the challenges remain formidable for all but small-to-moderately-large bodies. A table is given which illustrates this point by providing an estimate of the number of unknowns that need to be handled for deriving the radiation pattern of one or more slots on a finite cylinder of radius r and length L (similar estimates are valid for microstrip patch antennas located on the cylinder as well). We introduce an extrapolation technique, and combine it with the reciprocity approach, for predicting the radiation patterns of antennas located on large structures. The procedure is outlined.
Stereo Reconstruction from Multiple Views (1995)

We present a unified framework for 3-D shape reconstruction that allows us to combine multiple information sources—such as stereo and shape-from-shading—derived from images whose vantage points may be very different. A formal integration framework is critical because, in recovering complicated surfaces, the information from a single source is often insufficient to provide a unique answer. We describe two complementary implementations of this paradigm that both rely on deforming a generic object-centered 3-D representation of the surface so as to minimize an objective function. The first implementation models the surface as a triangulated mesh. The second models it as a set of particles that interact with each other through forces that tend to align them.
Performance of the IBIS/Tyrer-Cuzick (TC) Model by race/ethnicity in the Women’s Health Initiative. (2020)

1503 Background: The TC model, a breast cancer (BC) risk assessment tool based on family cancer history, reproductive and lifestyle factors is used to guide BC screening and prevention. TC was developed and validated largely in non-Hispanic White (NHW) women. We evaluated the calibration and discrimination of TC version 7.02 among racially/ethnically diverse post-menopausal women enrolled in the Women’s Health Initiative (WHI) clinical trials or observational study. Methods: WHI enrolled post-menopausal women from 1993-1998 and followed them prospectively for BC incidence. We included women aged ≤80 years at enrollment with no prior BC or mastectomy and with data required for TC, including weight, height, ages at menarche, first birth and menopause, menopausal hormone therapy use and family history of breast or ovarian cancer in first or second-degree relatives. Calibration was assessed by the ratio of observed BC cases to the number expected by TC (O/E), with expected cases calculated as the sum of cumulative hazards. We tested for differential discrimination by race/ethnicity (NHW, African American, Hispanic, Asian/Pacific Islander, Native American, other) using Cox regression. Time to BC was modeled using age, race/ethnicity, TC estimate (transformed by log of relative lifetime risk), and a term for interaction between race/ethnicity and TC estimate. Results: During the follow-up period (median 18.9 years, maximum 23.4 years), 6,836 new BC cases were diagnosed among 91,893 women. TC was well-calibrated overall (O/E 0.95) in NHW and African Americans, but over-estimated risk for Hispanics (O/E 0.75, Table). Results suggested good calibration for Asian/Pacific Islanders and Native Americans, but sample sizes were small. Discrimination did not differ significantly by race/ethnicity (two-sided p-value for interaction = 0.33). Conclusions: TC provided similar risk discrimination among post-menopausal women of different racial/ethnic groups over nearly 20 years of follow-up; however, it overestimated risk for Hispanics. Future studies in diverse populations are warranted, with need for a more accurate breast cancer risk assessment tool for Hispanics. [Table: see text]
The α1ECalcium Channel Exhibits Permeation Properties Similar to Low-Voltage-Activated Calcium Channels (1996)

The physiological and pharmacological properties of the α 1E calcium (Ca) channel subtype do not exactly match any of the established categories described for native neuronal Ca currents. Many of the key diagnostic features used to assign cloned Ca channels to their native counterparts, however, are dependent on a number of factors, including cellular environment, β subunit coexpression, and modulation by second messengers and G-proteins. Here, by examining the intrinsic pore characteristics of a family of transiently expressed neuronal Ca channels, we demonstrate that the permeation properties of α 1E closely resemble those described for a subset of low-threshold Ca channels. The α 1A (P-/Q-type), α 1B (N-type), and α 1C (L-type) high-threshold Ca channels all exhibit larger whole-cell currents with barium (Ba) as the charge carrier as compared with Ca or strontium (Sr). In contrast, macroscopic α 1E currents are largest in Sr, followed by Ca and then Ba. The unique permeation properties of α 1E are maintained at the single-channel level, are independent of the nature of the expression system, and are not affected by coexpression of α 2 and β subunits. Overall, the permeation characteristics of α 1E are distinct from those described for R-type currents and share some similarities with native low-threshold Ca channels.
Ensembles of neural networks with generalization capabilities for vehicle fault diagnostics (2009)

This paper presents a two-step ensemble approach for vehicle fault diagnostics, an ensemble selection algorithm, BFES, and an analog Bayesian ensemble decision function, A-Bayesian-Entropy. We show through experiments that a neural network ensemble designed and trained by the proposed methodology, and selected by BFES with A-Bayesian-Entropy as the ensemble decision function can generalize well to vehicle models that are different from the vehicles used to generate training data.
Tunable Filter for Orbital-Angular-Momentum Multiplexed Optical Channels (2013)

A tunable orbital angular momentum (OAM) mode filter is proposed. Filtering/blocking selected channels from 4 spatially multiplexed OAM channels is demonstrated. An OSNR penalty of &lt;2 dB is observed when using the filter for 100 Gb/s QPSK data channels.
Individual capacitor voltage balancing in H-bridge cascaded multilevel STATCOM at zero current operating mode (2015)

Individual capacitor voltage balancing is one of the challenges in the field of multilevel converters, especially when the phase legs of the converter are connected in star configuration. This issue can be even more problematic when the converter is operating close to zero average current operating mode. This paper first shows the issue related to the capacitor voltage balancing at zero average-current mode and second proposes a novel algorithm to overcome this problem. The method proposes a modulation technique for individual balancing in H-bridge cascaded multilevel converters operated at zero average-current mode. The proposed algorithm modifies the conventional sorting algorithm based on current ripple. The individual DC-link voltage control method is applied to a 19-level star-connected cascaded converter in PSCAD and simulation results verify the ability of the proposed method in maintaining the balancing of the capacitors voltages at zero current injection mode. Several practical limitation such as forward voltage drop over semiconductor elements, noise in measured data, delay in the digital controller, switching deadtime, and grid voltage harmonics are also considered in the model.
Waning Vaccine Immunity and Vaccination Responses in Children Treated for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study (2020)

NCT02447718.
Statistical Sinogram Restoration in Dual-Energy CT for PET Attenuation Correction (2009)

Dual-energy (DE) X-ray computed tomography (CT) has been found useful in various applications. In medical imaging, one promising application is using low-dose DECT for attenuation correction in positron emission tomography (PET). Existing approaches to sinogram material decomposition ignore noise characteristics and are based on logarithmic transforms, producing noisy component sinogram estimates for low-dose DECT. In this paper, we propose two novel sinogram restoration methods based on statistical models: penalized weighted least square (PWLS) and penalized likelihood (PL), yielding less noisy component sinogram estimates for low-dose DECT than classical methods. The proposed methods consequently provide more precise attenuation correction of the PET emission images than do previous methods for sinogram material decomposition with DECT. We report simulations that compare the proposed techniques and existing approaches.
High performance robust linear controller synthesis for an induction motor using a multi-objective hybrid control strategy (2004)

Two-degrees-of-freedom (2DOF) controller design is viewed as a standard technique capable of simultaneously addressing the performance objectives of the main operating modes - tracking and disturbance rejection - of an induction motor control system. However, in a typical industrial reduced cost controller implementation, the open-loop prefilter performance in the 2DOF topology could be severely degraded by the controller uncertainty, i.e., the mismatch between the dynamics of the analytical controller representation and its realization in software/hardware. This problem is addressed in the present work by a multi-objective hybrid control strategy. The latter consists in employing in each mode the corresponding optimally tuned One-degree-of-freedom (1DOF) design robust with respect to both the plant and the controller uncertainty, and organizing a rapid and smooth switching, or transfer, between the mode-specific controllers to provide sequencing of the operating modes, as necessary. Simulation results show that the technique proposed yields the fast switching robust controllers that provide the desired performance under rather significant controller uncertainty across the entire induction motor operating sequence, thereby offering an alternative, minimally affected by the reduced cost controller implementation, to a 2DOF design.
A Wearable Magneto-Inertial System for Gait Analysis (H-Gait): Validation on Normal Weight and Overweight/Obese Young Healthy Adults (2017)

<i>Background</i>: Wearable magneto-inertial sensors are being increasingly used to obtain human motion measurements out of the lab, although their performance in applications requiring high accuracy, such as gait analysis, are still a subject of debate. The aim of this work was to validate a gait analysis system (H-Gait) based on magneto-inertial sensors, both in normal weight (NW) and overweight/obese (OW) subjects. The validation is performed against a reference multichannel recording system (STEP32), providing direct measurements of gait timings (through foot-switches) and joint angles in the sagittal plane (through electrogoniometers). <i>Methods</i>: Twenty-two young male subjects were recruited for the study (12 NW, 10 OW). After positioning body-fixed sensors of both systems, each subject was asked to walk, at a self-selected speed, over a 14-m straight path for 12 trials. Gait signals were recorded, at the same time, with the two systems. Spatio-temporal parameters, ankle, knee, and hip joint kinematics were extracted analyzing an average of 89 ± 13 gait cycles from each lower limb. Intraclass correlation coefficient and Bland-Altmann plots were used to compare H-Gait and STEP32 measurements. Changes in gait parameters and joint kinematics of OW with respect NW were also evaluated. <i>Results</i>: The two systems were highly consistent for cadence, while a lower agreement was found for the other spatio-temporal parameters. Ankle and knee joint kinematics is overall comparable. Joint ROMs values were slightly lower for H-Gait with respect to STEP32 for the ankle (by 1.9° for NW, and 1.6° for OW) and for the knee (by 4.1° for NW, and 1.8° for OW). More evident differences were found for hip joint, with ROMs values higher for H-Gait (by 6.8° for NW, and 9.5° for OW). NW and OW showed significant differences considering STEP32 (<i>p</i> = 0.0004), but not H-Gait (<i>p</i> = 0.06). In particular, overweight/obese subjects showed a higher cadence (55.0 vs. 52.3 strides/min) and a lower hip ROM (23.0° vs. 27.3°) than normal weight subjects. <i>Conclusions</i>: The two systems can be considered interchangeable for what concerns joint kinematics, except for the hip, where discrepancies were evidenced. Differences between normal and overweight/obese subjects were statistically significant using STEP32. The same tendency was observed using H-Gait.
Spectroscopic Properties of C-Phycocyanin and of Its α and β Subunits (1973)

Abstract Synechococcus sp. (Anacystis nidulans) C-phycocyanin and its α and β subunits have been examined with respect to spectroscopic properties and aggregation behavior. In 0.05 m phosphate buffer at pH 7.0, and a protein concentration of 2.1 x 10-5 m, the α subunit exhibited a λmax of 620 nm (em = 0.98 x 105 m-1 cm-1), and a maximum molecular ellipticity, [θ]620, of 30.2 x 104 deg cm2 per dmole, while the β subunit exhibited a λmax of 608 nm (em = 1.43 x 105 m-1 cm-1), and a maximum [θ]600 of 56.1 x 104 deg cm2 per dmole. Fluorescence polarization spectra of native phycocyanin indicate the presence of two different chromophore types in this protein, those that absorb at shorter wave length (s type) sensitizing those that absorb and emit at longer wave length (f type) (see Teale, F. W. J., and Dale, R. E. (1970) Biochem. J. 116, 161–169). The absorption characteristics of the β subunit indicate that it contains the s type of chromophore, whereas those of the α subunit are consistent with the presence of the f type of chromophore. As reported earlier by others, aggregation of phycocyanin results in a red shift of the absorption maximum, and a large increase in the extinction coefficient. Phycocyanin, under conditions where it is essentially monomeric, i.e. 7.2 x 10 -7 m protein in 0.05 m phosphate buffer at pH 7.0, is characterized by a λmax of ∼615 nm (em ∼ 2.3 x 105 m-1 cm-1), while hexameric phycocyanin, in 0.2 m acetate buffer at pH 5.5, exhibits a λmax of 621 nm (em = 3.33 x 105 m-1 cm-1). Changes in the circular dichroism spectrum observed upon phycocyanin aggregation suggest strong intermolecular interaction between the chromophores. Phycocyanin, formed by recombination of α and β subunits, was found to be indistinguishable from native phycocyanin with respect to circular dichroism and absorption spectra.