gebhart/patrepeval huggingface dataset:
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior (2014)

Perlecan/HSPG2, a large heparan sulfate (HS) proteoglycan, normally is expressed in the basement membrane (BM) underlying epithelial and endothelial cells. During prostate cancer (PCa) cell invasion, a variety of proteolytic enzymes are expressed that digest BM components including perlecan. An enzyme upregulated in invasive PCa cells, matrilysin/matrix metalloproteinase-7 (MMP-7), was examined as a candidate for perlecan proteolysis both in silico and in vitro. Purified perlecan showed high sensitivity to MMP-7 digestion even when fully decorated with HS or when presented in native context connected with other BM proteins. In both conditions, MMP-7 produced discrete perlecan fragments corresponding to an origin in immunoglobulin (Ig) repeat region domain IV. While not predicted by in silico analysis, MMP-7 cleaved every subpart of recombinantly generated perlecan domain IV. Other enzymes relevant to PCa that were tested had limited ability to cleave perlecan including prostate specific antigen, hepsin, or fibroblast activation protein α. A long C-terminal portion of perlecan domain IV, Dm IV-3, induced a strong clustering phenotype in the metastatic PCa cell lines, PC-3 and C4-2. MMP-7 digestion of Dm IV-3 reverses the clustering effect into one favoring cell dispersion. In a C4-2 Transwell® invasion assay, perlecan-rich human BM extract that was pre-digested with MMP-7 showed loss of barrier function and permitted a greater level of cell penetration than untreated BM extract. We conclude that enzymatic processing of perlecan in the BM or territorial matrix by MMP-7 as occurs in the invasive tumor microenvironment acts as a molecular switch to alter PCa cell behavior and favor cell dispersion and invasiveness.
Supplementary Figure Legends from Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner (2023)

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Lower-Limb Strategy Assessment during a Virtual Reality based Dual-Motor-Task (2020)

The technical development of the virtual reality platform provides multiple levels to understand human behaviors in simulated environments and to develop interventions for functional rehabilitation. In this study, a dual-task paradigm in a virtual environment is designed where both tasks demand motor skills. Three healthy adults (mean age: 24.3 years) participated in this study. The experiment involved two conditions of overground walking in virtual reality - normal walking and catch and throw a ball while walking. In this work, we investigated the dual-task gait characteristics and the strategy adopted at the lower limb to perform better in the secondary task of throwing the ball. Results show that more balls were thrown during the terminal stance and pre-swing phase of the dominant leg. Thus, the participants utilized the forward momentum built during the foot-to-foot transition by the lagging dominant foot while throwing. This study provides a new and engaging paradigm to analyze dual-motor-task in a virtual reality environment. It can be used as a powerful tool to characterize gait and cognitive performance measures in individuals.
A 112Gb/s PAM-4, 168Gb/s PAM-8 7bit DAC-Based Transmitter in 7nm FinFET (2021)

This paper describes a 56Gbaud 7bit DAC based transmitter demonstrating data-rates of 112Gb/s, 145Gb/s and 168Gb/s in PAM4, PAM6, and PAM8 respectively. The transmitter with 1.2Vppd high-swing driver is implemented in a 7nm FinFET process. The power efficiency is 1.5pJ/b (PAM4) & 1.0pJ/b (PAM8).
Digital holographic microscopy and machine learning approach for the classification of inflammation in macrophages (2019)

Digital holographic microscopy system is developed for the quantitative phase imaging of the macrophages. The results are utilized as input of the support vector machine based classifier for the detection of inflammation in macrophages.
Carbon Nanotube-Polycarbonate Composites (2005)

Carbon nanotubes were investigated as high-performance reinforcement for polymer composites. The inherently superior mechanical properties of nanotubes coupled with the high interfacial surface areas available to dissipate energy suggest that nanotube-polymer composites would have excellent potential as high-strength, impact-resistant materials. The multiwall carbon nanotubes (MWNT) produced by arc and chemical vapor deposition and the double-walled nanotubes (DWNT) produced by the arc process were investigated as reinforcement in polycarbonate thermoplastic. The as-grown non-polar nanotubes did not disperse readily in high molecular weight polycarbonates. However, a significant increase in compressive strength was achieved by using uniformly dispersed nanotubes in low molecular weight polycarbonate and also in an optimum ratio of low and high molecular weight polycarbonate. The compressive strength enhancement for the same polymer matrix by the different nanotubes is dependent on the nanotube’s purity, the inherent properties (strength and dimension) of the nanotubes, and polymer compatability.
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia (2016)

MLL1 and DOT1L are chromatin regulators that control HOX, MEIS1, and FLT3 expression and are therapeutic targets in NPM1<sup>mut</sup> AML. Combinatorial small-molecule inhibition has synergistic on-target activity and constitutes a novel therapeutic concept for this common AML subtype. Cancer Discov; 6(10); 1166-81. ©2016 AACR.See related commentary by Hourigan and Aplan, p. 1087This article is highlighted in the In This Issue feature, p. 1069.
Biochemistry of bone morphogenetic proteins (2002)

Bone has a remarkable ability for regeneration and repair. The cellular events associated with this repair process mimic closely those events associated with embryonic bone development. In 1965, Dr. Marshall Urist showed that new bone formation could be induced using demineralized bone matrix [1]. By implanting demineralized bone particles intramuscularly in animals, he observed the formation of new bone. With these studies, Dr. Urist pioneered the concept that there is some substance naturally present in bone, which is responsible for the regeneration and repair activity. He called this substance bone morphogenetic protein (BMP) and initiated a search for these molecules.
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors (2018)

Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat. Cell-based experiments demonstrate that corin exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes. CoREST knockdown, gene expression, and ChIP studies suggest that corin's favorable pharmacologic effects may rely on an intact CoREST complex. Corin was also effective in slowing tumor growth in a melanoma mouse xenograft model. These studies highlight the promise of a new class of two-pronged hybrid agents that may show preferential targeting of particular epigenetic regulatory complexes and offer unique therapeutic opportunities.
Capacity of Symmetric K-User Gaussian Very Strong Interference Channels (2008)

This paper studies a symmetric <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> user Gaussian interference channel with <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> transmitters and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> receivers. A "very strong" interference regime is derived for this channel setup. A "very strong" interference regime is one where the capacity region of the interference channel is the same as the capacity region of the channel with no interference. In this regime, the interference can be perfectly canceled by all the receivers without incurring any rate penalties. A "very strong" interference condition for an example symmetric <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> user deterministic interference channel is also presented.
Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology (2016)

Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that scavenges sialic acid from the host in a crucial interplay for T. cruzi life cycle. The acquisition of the sialyl residue allows the parasite to avoid lysis by serum factors and to interact with the host cell. A major drawback to studying the sialylation kinetics and turnover of the trypomastigote glycoconjugates is the difficulty to identify and follow the recently acquired sialyl residues. To tackle this issue, we followed an unnatural sugar approach as bioorthogonal chemical reporters, where the use of azidosialyl residues allowed identifying the acquired sugar. Advanced microscopy techniques, together with biochemical methods, were used to study the trypomastigote membrane from its glycobiological perspective. Main sialyl acceptors were identified as mucins by biochemical procedures and protein markers. Together with determining their shedding and turnover rates, we also report that several membrane proteins, including TS and its substrates, both glycosylphosphatidylinositol-anchored proteins, are separately distributed on parasite surface and contained in different and highly stable membrane microdomains. Notably, labeling for α(1,3)Galactosyl residues only partially colocalize with sialylated mucins, indicating that two species of glycosylated mucins do exist, which are segregated at the parasite surface. Moreover, sialylated mucins were included in lipid-raft-domains, whereas TS molecules are not. The location of the surface-anchored TS resulted too far off as to be capable to sialylate mucins, a role played by the shed TS instead. Phosphatidylinositol-phospholipase-C activity is actually not present in trypomastigotes. Therefore, shedding of TS occurs via microvesicles instead of as a fully soluble form.
Implications of Impacts of Climate Change on Forest Product Flows and Forest Dependent Communities in the Western Ghats, India (2014)

The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non-timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.
Correction éditoriale d'ARN messager codant pour des sous-unités des récepteurs canaux au glutamate (1991)

Correction éditoriale d'ARN messagers codant pour des sous-unités des récepteurs-canaux au glutamate
Mechanism of cellular fatty acid uptake (1992)

Conference Article| November 01 1992 Mechanism of cellular fatty acid uptake W. Stremmel; W. Stremmel * 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany *Address for correspondence: Prof. Dr. W. Stremmel, Dept. of Gastroenterology, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 4000 Düsseldorf, Germany. Search for other works by this author on: This Site PubMed Google Scholar H. Kleinert; H. Kleinert 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar B. A. Fitscher; B. A. Fitscher 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar J. Gunawan; J. Gunawan 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar C. Klaassen-Schlüter; C. Klaassen-Schlüter 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar K. Möller; K. Möller 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar M. Wegener M. Wegener 1Division of Gastroenterology, Department of Internal Medicine, University Hospital Düsseldorf, Germany Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: July 16 1992 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1992 Biochemical Society1992 Biochem Soc Trans (1992) 20 (4): 814–817. https://doi.org/10.1042/bst0200814 Article history Received: July 16 1992 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation W. Stremmel, H. Kleinert, B. A. Fitscher, J. Gunawan, C. Klaassen-Schlüter, K. Möller, M. Wegener; Mechanism of cellular fatty acid uptake. Biochem Soc Trans 1 November 1992; 20 (4): 814–817. doi: https://doi.org/10.1042/bst0200814 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: MFABP, membrane fatty acid binding protein, cFABP, cytosolic fatty acid binding protein This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
LSTMs for Hydrological Modelling in Swiss Catchments (2023)

Simulation of the catchment rainfall-runoff transformation with physically based watershed models is a traditional way to predict streamflow and other hydrological variables at catchment scales. However, the calibration of such models requires large data inputs and computational power and contains many parameters which are often impossible to constrain or validate. An alternative approach is to use data-driven machine learning for streamflow prediction.In the past few years, LSTM (long short-term memory) models and its variants have been explored in rainfall-runoff modelling. Typical applications use daily climate variables as inputs and model the rainfall-runoff transformation processes with different timescales of memory. This is especially useful as delays in runoff production by snow accumulation and melt, soil water storage, evapotranspiration, etc., can be included. In contrast to feed-forward ANNs (artificial neural networks), LSTMs are capable of maintaining the sequential temporal order of inputs, and compared to RNNs (recurrent neural networks), of learning the long-term dependencies. [1]However, current work on LSTMs mostly focuses on the USA, the UK and Brazil, where CAMELS datasets are available [1, 2, 3]. Catchments at higher altitudes with snow-driven dynamics and sometimes glaciers are present in small number in these datasets (if at all). Systematic applications of LSTMs for streamflow prediction in climates where a significant part of the catchments are snow and ice dominated are missing. In this work, an FS-LSTM (fast slow-LSTM) previously applied in Brazil is adapted for Swiss catchments to fill this gap [3]. The FS-LSTM explored builds on the work of Hoedt et al. (2021) that imposed mass constraints on an LSTM, called MC-LSTM [4]. FS-LSTM adds a fast and slow part for streamflow, containing rainfall and soil moisture respectively. We will discuss benchmark results against an existing semi-distributed conceptual model widely used in Switzerland for streamflow simulation [5].&amp;#160;References:[1]: Kratzert et al., Rainfall-runoff modelling using Long Short-Term Memory (LSTM) networks, 2018.[2]: Lees et al., Hydrological concept formation inside long short-term memory (LSTM) networks, 2022.[3]: Quinones et al., Fast-Slow Streamflow Model Using Mass-Conserving LSTM, 2021.[4]: Hoedt et al., MC-LSTM: Mass-Conserving LSTM, 2021.[5]: Viviroli et al., An introduction to the hydrological modelling system PREVAH and its pre- and post-processing-tools, 2009.
Investigation of Extracting Photonic Crystal Lattices for Guided Modes of GaAs-Based Heterostructures (2008)

The issue of extracting guided modes from a standard light-emitting heterostructure similar to those of visible or near-infrared light-emitting diodes is considered with respect to the role of lattices and of the amount of omnidirectionality in the extraction performances. Triangular lattices are first-order natural candidates. We examine first whether they can be made omnidirectional thanks to a grating + coupler combination initially proposed by Fehrembach et al (2001), whereby the short periodicity concentrates emission in few in-plane modes, and the double periodicity extracts it. We then examine lattices that directly extract, for a Ga(Al)As system on a GaAs substrate, with a specific 3-D mode decay calculation. We compare triangular and Archimedean lattices experimentally and point out the role of photonic strength also through a spectrally and angularly resolved experiment.
INTEGRATION OF NONDESTRUCTIVE TESTING IN AIRCRAFTS MENTENANCE (2011)

Introduction In aircraft maintenance programme it is important to inspect the mechanical damage and assess the extent of the repair work. But in schedule maintenance it is a difficult to finding the defects rapidly, as the maintenance of aircraft must be accomplished within scheduled time and same to be released in time for commercial operation. During aircraft maintenance 'NONDESTRUCTIVE TESTING' (NDT) is the most economical way of performing inspection and this is the only way of discovering defects. In simply we can say, NDT can detect cracks or any other irregularities in the airframe structure and engine components which are obviously not visible to the naked eye. Structures & different assemblies of aircraft are made from various materials, such as aluminium alloy, steel, titanium and composite materials. To dismantle the aircraft in pieces and then examine each component would take a long time, so the NDT method and equipment selection must be fast and effective. In the present trend of NDT application on aircraft 70-80% of NDT is performed on the airframe, structure, landing gears and the rest carried out on engine & related components. In order to maintain the aircraft defects free and ensure a high degree of quality & reliability and as a part of inspection programme, usually following NDT methods are applied: 1)Liquid penetrant 2)Magnetic particle, 3)Eddy current 4)Ultrasonic 5)Radiography 6)Visual/Optical 7)Sonic/Resonance 8)Infrared Thermography.
Analytical Model for Low-Frequency Transmission Loss Calculation of Zero-Prestressed Plates With Arbitrary Mass Loading (2019)

Abstract As the importance of sound attenuation through weight-critical structures has grown and mass law based strategies have proven impractical, engineers have pursued alternative approaches for sound attenuation. Membrane-type acoustic metamaterials have demonstrated sound attenuation significantly higher than mass law predictions for narrow, tunable bandwidths. Similar phenomena can be achieved with plate-like structures. This paper presents an analytical model for the prediction of transmission loss through rectangular plates arbitrarily loaded with rigid masses, accommodating any combination of clamped and simply supported boundary conditions. Equations of motion are solved using a modal expansion approach, incorporating admissible eigenfunctions given by the natural mode shapes of single-span beams. The effective surface mass density is calculated and used to predict the transmission loss of low-frequency sound through the plate–mass structure. To validate the model, finite element results are compared against analytical predictions of modal behavior and shown to achieve agreement. The model is then used to explore the influence of various combinations of boundary conditions on the transmission loss properties of the structure, revealing that the symmetry of plate mounting conditions strongly affects transmission loss behavior and is a critical design parameter.
Observation of B[0 over s] → [bar over D][superscript 0]K[0 over S] and Evidence for B[0 over s] → [bar over D][superscript *0]K[0 over S] Decays (2016)

The first observation of the B[0 over s] → [bar over D][superscript 0]K[0 over S] decay mode and evidence for the B[0 over s] → [bar over D][superscript *0]K[0 over S] decay mode are reported. The data sample corresponds to an integrated luminosity of 3.0 fb[superscript -1] collected in pp collisions by LHCb at center-of-mass energies of 7 and 8 TeV. The branching fractions are measured to be B(B[0 over s] → [bar over D][superscript 0][bar over K][superscript 0]) = [4.3 ± 0.5(stat) ± 0.3(syst) ± 0.3(frag) ± 0.6(norm)] × 10[superscript -4], B(B[0 over s] → [bar over D][superscript *0][bar over K][superscript 0]) = [2.8 ± 1.0(stat) ± 0.3(syst) ± 0.2(frag) ± 0.4(norm)] × 10[superscript -4],where the uncertainties are due to contributions coming from statistical precision, systematic effects, and the precision of two external inputs, the ratio f[subscript s]/f[subscript d] and the branching fraction of B[superscript 0] → [bar over D][superscript 0]K[0 over S], which is used as a calibration channel.
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods (2011)

A combination of flow and batch chemistries has been successfully applied to the assembly of a series of trisubstituted drug-like pyrrolidines. This study demonstrates the efficient preparation of a focused library of these pharmaceutically important structures using microreactor technologies, as well as classical parallel synthesis techniques, and thus exemplifies the impact of integrating innovative enabling tools within the drug discovery process.