gebhart/patrepeval huggingface dataset:
Influence of ultrasonographers training on prenatal diagnosis of congenital heart diseases: a 12‐year population‐based study (2008)

This study supports the hypothesis of a beneficial effect of CPDPN on prenatal diagnosis of CHDs. These centers not only fulfill their primary purpose but also operate as learning centers in which screening sonographers may improve their practice.
Two‐step simulation approach for laser shock peening (2019)

Abstract Laser shock peening (LSP) is a surface modification technique to introduce compressive residual stresses (RS) with a high magnitude in the near surface region of the material. Due to non‐linear interactions (e.g. laser absorption by plasma, shock wave propagation, etc.) and a high number of parameters, it is difficult to study and optimize the process based on experiments alone. Therefore, a two‐step simulation approach is proposed in this paper, where two models are combined, because one model of the complete process is difficult to derive, due to the different characteristics of the plasma formation and the shock wave propagation in the material. On one hand, a global model including plasma and shock wave descriptions is applied for the LSP of an aluminium sample with water confinement. The numerical solution of this model, applied for a 3×3 mm 2 focus size, 5 J and 20 ns (full width at half maximum (FWHM)) laser pulse, allows to determine the temporal plasma pressure evolution on the material surface. On the other hand, a finite element simulation is used to calculate the RS distribution within the target material, where the plasma pressure is applied as a surface loading for the aluminium alloy AA2198‐T3. The simulated residual stresses are fitted to measurements via parameter variation of the global model. The identified values and the two‐step simulation approach can be used in future work to predict stress states of materials after LSP for various process parameters variations.
Using Containers on Bluemix to Run Swift Code (2017)

This chapter describes Docker and how it can be used as a development tool and get a brief introduction to the Kubernetes platform. The chapter also discusses how to create a Kubernetes cluster on Bluemix to host a Swift application, including demonstration on how to bind Bluemix services to a Kubernetes cluster. Before one can create one's own Docker container, one ?rst needs to create a Docker image. A Docker image is a binary artifact that contains the speci?cation for the container. Thinking in object-oriented programming terms, a class is to an object instance what a Docker image is to a container. IBM maintains three Docker images that one can use for development and deployment of applications and for educational purpose. A Docker tool can be used to create a Docker container and execute a command in it. Swift packages that serve as wrappers for system-level packages require those packages to be installed before one attempts to build one's application using Swift Package Manager. These system packages can be speci?ed in a Docker image as dependencies.
Investigation on automated visual SMD-PCB inspection based on multimodal one-class novelty detection (2023)

In electronics manufacturing, the inspection of defects of electrical components on printed circuit boards (SMD-PCB) is an import part of the production chain. This process is normally implemented by automatic optical inspection (AOI) systems based on classical computer vision and multimodal imaging. Despite the highly developed image processing, misclassifications can occur due to the different, variable appearance of objects and defects and constantly emerging defect types, which can only be avoided by constant manual supervision and adaption. Therefore, a lot of manpower is needed to do this or to perform a subjective follow-up. In this paper, we present a new method using the principle of multimodal deep learning-based one-class novelty-detection to support AOIs and operators to detect defects more accurate or to determine whether something needs to be changed. By combining with a given AOI classification a powerful adaptive AOI system can be realized. To evaluate the performance of the multimodal novelty-detector, we conducted experiments with SMD-PCB-components imaged in texture and geometric modalities. Based on the idea of one-class-detection only normal data is needed to form training sets. Annotated defect data which is normally only insufficiently available, is only used in the tests. We report about some experiments in accordance with the consistence of data categories to investigate the applicability of this approach in different scenarios. Hereby we compared different state-of-the-art one-class novelty detection techniques using image data of different modalities. Besides the influence of different data fusion methods are discussed to find a good way to use this data and to show the benefits using multimodal data. Our experiments show an outstanding performance of defect detection using multimodal data based on our approach. Our best value of the widely known AUROC reaches more than 0.99 with real test data.
Efficient Condition-based Representations for Long-Term Visual Localization. (2018)

We propose an approach to localization from images that is designed to explicitly handle the strong variations in appearance happening when capturing conditions change throughout the day or across seasons. As revealed by recent long-term localization benchmarks, both traditional feature-based and retrieval-based approaches still struggle to handle such changes. Our novel retrieval-based method introduces condition-specific sub-networks allowing the computation of global image descriptors that are explicitly dependent of the capturing conditions. We compare our approach to previous localization methods on very recent challenging benchmarks, and observe that our method outperforms them by a large margin in case of day-night variation, where repeatable feature points cannot be identified or matched.
Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients (2019)

The prevention of relapse is the major therapeutic challenge in older patients with acute myeloid leukemia (AML) who have obtained a complete remission (CR) on intensive chemotherapy. In this randomized phase 3 study (HOVON97) in older patients (≥60 years) with AML or myelodysplastic syndrome with refractory anemia with excess of blasts, in CR/CR with incomplete hematologic recovery (CRi) after at least 2 cycles of intensive chemotherapy, we assessed the value of azacitidine as postremission therapy with respect to disease-free survival (DFS; primary end point) and overall survival (OS; secondary end point). In total, 116 eligible patients were randomly (1:1) assigned to either observation (N = 60) or azacitidine maintenance (N = 56; 50 mg/m<sup>2</sup>, subcutaneously, days 1-5, every 4 weeks) until relapse, for a maximum of 12 cycles. Fifty-five patients received at least 1 cycle of azacitidine, 46 at least 4 cycles, and 35 at least 12 cycles. The maintenance treatment with azacitidine was feasible. DFS was significantly better for the azacitidine treatment group (logrank; <i>P</i> = .04), as well as after adjustment for poor-risk cytogenetic abnormalities at diagnosis and platelet count at randomization (as surrogate for CR vs CRi; Cox regression; hazard ratio, 0.62; 95% confidence interval, 0.41-0.95; <i>P</i> = .026). The 12-month DFS was estimated at 64% for the azacitidine group and 42% for the control group. OS did not differ between treatment groups, with and without censoring for allogeneic hematopoietic cell transplantation. Rescue treatment was used more often in the observation group (n = 32) than in the azacitidine maintenance group (n = 9). We conclude that azacitidine maintenance after CR/CRi after intensive chemotherapy is feasible and significantly improves DFS. The study is registered with The Netherlands Trial Registry (NTR1810) and EudraCT (2008-001290-15).
Alkali metal and magnesium enamides from metallation of the alkyl ligands [(2-Pyr)(SiMe3)CH2] and [6-Me-(2-Pyr)(SiMe3)CH2]: a solid state and ab initio study† (2001)

The alkali metal complexes [rNa·(pmdta)]2, 1, [rK·(pmdta)]2, 2, [rNa·(tmeda)]2, 3, [r′Li·(pmdta)], 4, and the magnesium complex, [(r)2Mg·(hmpa)2], 5, formed on metallation of the monosilylated ligands [(2-Pyr)(SiMe3)CH2] (= rH) and [6-Me-(2-Pyr)(SiMe3)CH2] (= r′H), rather than being metal alkyls, are all metal enamides in the solid state, as evidenced by single crystal X-ray diffraction studies. Even in the presence of the bi- and tri-dentate donors tmeda (= N,N,N′,N′-tetramethylethylenediamine) and pmdta (= N,N,N′,N′,N″-pentamethyldiethylenetriamine) the heavier alkali metal complexes are found to be dimeric. The Li complex is monomeric and adopts the enamide configuration despite the presence of additional steric bulk on introduction of a Me group on the 6-position of the pyridyl ring. This preference for an enamide configuration, rather than that of carbanion or aza-allyl, has been studied by ab initio MO calculations. These confirmed that as the coordination environment of the metal increases the enamide form rather then the aza-allylic form becomes the most energetically favoured configuration.
Live cell imaging and single cell tracking of mesenchymal stromal cellsin vitro (2016)

Cells are highly dynamic biological systems that are comprised of a vast number of molecular processes that interact both spatially and temporally. For mesenchymal stromal cell (MSC) cultures, which are heterogeneous and may only contain a small population of stem cells, single cell analyses are even more critical. Live cell imaging is a multidisciplinary area of research that has evolved through input from engineers, physicists, chemists, biologists, computer scientists, and mathematicians. Image acquisition parameters must be defined for each live cell imaging experiment. Image restoration and enhancement methods are required to improve the accuracy of cellular tracking and fluorescent quantification. Live cell imaging experiments, particularly long-term imaging experiments, have the potential to generate a large volume of image data. Time-lapse imaging experiments generate image stacks for individual field of views (FOV) over a period of hours, days, or weeks.
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. (1998)

We tested the antineoplastic effect of the farnesyltransferase inhibitor L-744,832 in mammary and lymphoid tumors overexpressing the N-ras proto-oncogene in transgenic mice. Mice bearing mammary tumors were randomly assigned to receive daily 40 mg/kg s.c. injections of this compound (experimental group, n = 6) or vehicle (control group, n = 6) per day for 5.5 weeks. Treatment with the compound significantly reduced the mammary tumor mean growth rate in the experimental group (-0.7 mm3/day), as compared with the control group (+28.2 mm3/day; P < 0.001). There was a significant difference in lymphoma incidence at the end of the treatment between the experimental (0 of 6) and the control (3 of 6) groups (P < 0.05). Therefore, this compound is effective in treating in vivo mammary carcinomas and lymphomas in which an activated N-Ras pathway drives tumorigenesis. The number of apoptotic figures in mammary tumors was significantly higher (P = 0.04) in the experimental (14.7 +/- 8.1) than it was in the control (5.7 +/- 3.5) group, indicating that apoptotic induction could contribute to the mechanism of antitumor activity of this compound. We analyzed the level of processing of N-Ras and H-Ras after immunoprecipitation and Western blotting of protein extracts obtained from mammary tumors treated with L-744,832 or vehicle, either in vivo or in vitro (after primary culture of the same tumors), and from several in vitro treated control cell lines. In all compound-treated mammary tumors and cell lines, H-Ras was mostly unprocessed (more so after in vitro than after in vivo treatment), whereas N-Ras remained mostly processed. Both H-Ras and N-Ras remained fully processed in all vehicle-treated samples. These findings are consistent with a less intense antineoplastic effect of the treatment with the compound in our N-ras model than the effect previously reported for the same compound in H-ras transgenics. In addition, the finding that, in compound-treated mammary tumors, the N-Ras protein remains mainly processed suggests that, in our model, other proteins in addition to Ras may be a target for the compound. Our results and the previous findings of frequent N-ras activation in human hematopoietic malignancies support a role for L-744,832 in the treatment of lymphomas and of mammary carcinomas with an activated N-Ras pathway, as well as the testing of a farnesyl protein transferase inhibitor in humans to establish its clinical relevance.
Structure-function analysis of casein kinase 2 with synthetic peptides and anti-peptide antibodies. (1992)

Casein kinase 2 (CK2) is a ubiquitous, multifunctional protein-seryl/threonyl kinase that has been implicated in cellular regulation. Synthetic peptides were patterned after three highly conserved regions in CK2: the N terminus (CK2-NT); the lysine-rich, kinase subdomain III segment (CK2-III) (nomenclature of Hanks et al. (Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52)); and a 10-residue segment located near kinase subdomain X that is shared between CK2 and p34cdc2 (CK2/cdc2). The CK2-III and CK2/cdc2 peptides markedly stimulated the autophosphorylation of the alpha- and alpha'-subunits of purified CK2 from sea star oocytes, and they elicited up to 2-fold increases in its casein or phosvitin phosphotransferase activity. These peptides completely reversed nearly total inhibition of CK2 phosphotransferase activity toward itself, casein, and phosvitin by either heparin or poly(Glu,Tyr; 4:1), whereas CK2-NT was ineffective. Elution of CK2 from heparin-agarose with the CK2-III peptide indicated that this region of CK2 might mediate heparin binding to CK2. Affinity-purified rabbit polyclonal antibodies developed against both CK2-III and CK2/cdc2, but not CK2-NT, also produced up to 1.8-fold enhancements of the casein and phosvitin phosphotransferase activities of purified CK2. All three of the antipeptide antibody preparations immunoreacted with the alpha- and alpha'-subunits of CK2 on Western blots. These studies indicate that kinase subdomains III and X are involved in the modulation of CK2 phosphotransferase activity.
Review-Based Service Profiling and Recommendation (2016)

Finding desired services (e.g., restaurants) from a number of candidates is a difficult task. We usually look at the scores given by other customers or read their reviews for decision making, but it is time consuming. This paper presents review-based service recommendation using both a bag-of-words model and a skip-gram-based model. Namely, instead of checking the scores or review comments, a review is given to the system as a query, and the services to which similar reviews are given are recommended. We evaluated our algorithms by using Yelp's Academic Dataset. The experimental results show that the percentage of finding the corresponding restaurants as the top-1 candidate was 25% and that in the top-10 ranking was 51%.
Comparative study of Ga, In, and Mg doped ZnO thin-film scintillator with Geiger mode APD (2009)

Ga 25, 55, and 552 ppm doped, In 25, 53, and 141 ppm doped, Mg 1, 5, 10, 13 mol% doped ZnO thin film scintillators were grown by the Liquid Phase Epitaxy (LPE) method. Their transmittance, ¿-ray induced emission spectra were evaluated. The transmittance reached to 80% at wavelength longer than 390 nm for all the crystals. Two emission lines appeared at 390 and 550 nm, due to the free and bound excitons, respectively. Coupled with Multi Pixel Photon Counter (MPPC), the light yield and decay time were evaluated.
Anodisation of branched and columnar macropores in n‐type silicon under front‐side illumination (2007)

Abstract The growth of well‐defined regular columnar macropores under front‐side illumination on medium doped n‐type silicon has been investigated. The various morphologies observed, with branched or columnar pores, differ from those reported so far on substrates of both higher and lower resistivities. Unlike stated by the macropore growth model, current density is found to influence the pore growth rate. These observations indicate that, under the conditions used in this work, the pore growth is at the border between meso‐ and macroporous mechanism. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A new species of the genus Cerviniopsis from Sagami Bay, Japan and reinstatement of the genus Neocervinia, with a report on the male of Neocervinia itoi Lee & Yoo, 1998 (Copepoda: Harpacticoida: Aegisthidae) (2012)

Park, Eun-Ok, Shimanaga, Motohiro, Yoon, Suk Hyun, Lee, Wonchoel (2012): A new species of the genus Cerviniopsis from Sagami Bay, Japan and reinstatement of the genus Neocervinia, with a report on the male of Neocervinia itoi Lee & Yoo, 1998 (Copepoda: Harpacticoida: Aegisthidae). Zootaxa 3575: 27-48, DOI: 10.5281/zenodo.209382
Diaphragmatic dysfunction in neuromuscular disease, an MRI study (2021)

The aim of this exploratory study was to evaluate diaphragmatic function across various neuromuscular diseases using spirometry-controlled MRI. We measured motion of the diaphragm relative to that of the thoracic wall (cranial-caudal ratio vs. anterior posterior ratio; CC-AP ratio), and changes in the diaphragmatic curvature (diaphragm height and area ratio) during inspiration in 12 adults with a neuromuscular disease having signs of respiratory muscle weakness, 18 healthy controls, and 35 adult Pompe patients - a group with prominent diaphragmatic weakness. CC-AP ratio was lower in patients with myopathies (n=7, 1.25±0.30) and motor neuron diseases (n=5, 1.30±0.10) than in healthy controls (1.37±0.14; p=0.001 and p=0.008), but not as abnormal as in Pompe patients (1.12±0.18; p=0.011 and p=0.024). The mean diaphragm height ratio was 1.17±0.33 in patients with myopathies, pointing at an insufficient diaphragmatic contraction. This was also seen in patients with Pompe disease (1.28±0.36), but not in healthy controls (0.82±0.33) or patients with motor neuron disease (0.82±0.24). We conclude that spirometry-controlled MRI enables us to investigate respiratory dysfunction across neuromuscular diseases, suggesting that the diaphragm is affected in a different way in myopathies and motor neuron diseases. Whether MRI can also be used to evaluate progression of diaphragmatic dysfunction requires additional studies.
Towards the Generation of Self‐Healing Materials by Means of a Reversible Photo‐induced Approach (2011)

Photo-induced reversibility as a tool for self-healing: a reversible photo-induced dendritic macromonomer was synthesized and proven to form networks with different features depending on the crosslinking conditions. While networks formed from aqueous systems exhibited a reversible change in their crosslinking degree, networks generated in bulk underwent fully reversibility. The latter was then exploited for generating self-healing materials by means of a photo-induced treatment.
Analysis of the aspiration ratio of double-shrouded probes according to angle of attack and probe scale (2021)

To measure airborne particulate matter concentration over a wide range, a measurement system is mounted on various types of moving vehicles, such as high-speed trains, small drones, and airplanes. Depending on the purpose and range of measurement, the size of the moving vehicle used varies, and the sampling flow rate of the measurement system mounted on the vehicle also varies accordingly. Therefore, an isokinetic sampling inlet with a size suitable for each mobile measurement system must be used. In this study, the aspiration ratio according to various sizes of double-shrouded probes developed to enable representative sampling, including under high-speed flow conditions, was investigated. Considering the various speed ranges of the moving vehicle and relative angle between the moving direction of the vehicle and the surrounding flow direction, the free-stream velocity range around the double-shrouded probe was set to 0–300 km/h and the angle of attack was set to 0–30°. As the angle of attack increased, the aspiration ratio tended to decrease. When the angle of attack is fixed, we found that the aspiration ratio of the double-shrouded probe of various sizes can be made non-dimensional using the square root of the Stokes number. Based on these results, it is expected that the size of the double-shrouded probe suitable for various mobile measurement systems can be easily determined, and accurate measurement of dust concentration is possible through quick prediction of the aspiration ratio according to the velocity of the moving vehicle and angle of attack.Copyright © 2021 American Association for Aerosol Research
Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives (2018)

We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted <i>in vitro</i> and <i>in vivo</i> experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/β-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers.
Effects of dietary N-3 and saturated fats on growth rates of the human colonic cancer cell lines SW-620 and LS 174T in vivo in relation to tissue and plasma lipids. (1991)

Ninety nude mice were inoculated subcutaneously with 1 x 10(7) cells of the human colonic cancer cell lines, SW-620 and LS174T. Tumour growth was assessed weekly for three weeks whilst the animals were receiving one of three diets: control (4.6% fat), coconut (20% fat, saturated fatty acids) and Maxepa (20% fat; n-3 fatty acids). At the end of the study SW-620 tumour weights (mean +/- SD, gm) were: control = 0.38 +/- 0.22, coconut = 0.43 +/- 0.31, Maxepa 0.20 +/- 0.16; the LS174T tumour weights were control = 1.33 +/- 1.27, coconut = 0.47 +/- 0.74, Maxepa = 0.38 +/- 0.56 (p less than 0.001, analysis of covariance). The Maxepa diet produced significant retardation in tumour growth (p less than 0.001). This was associated with reduced levels of linoleic acid and arachidonic acid in adipose tissue and tumour lipids with incorporation of n-3 fatty acids (all p less than 0.01 at least, analysis of variance). Moreover, the Maxepa diet produced significant reductions of plasma cholesterol, phospholipids and triglycerides (all p less than 0.01).