gebhart/patrepeval huggingface dataset:
Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection (2018)

Natural killer cells are critical in the immune response to infection and malignancy. Prior studies have demonstrated that Crk family proteins can influence cell apoptosis, proliferation, and cell transformation. In this study, we investigated the role of Crk family proteins in mouse NK cell differentiation and host defense using a mouse CMV infection model. The number of NK cells, maturational state, and the majority of the NKR repertoire was similar in Crk x Crk-like (CrkL)-double-deficient and wild type NK cells. However, Crk family proteins were required for optimal activation, IFN-γ production, expansion, and differentiation of Ly49H<sup>+</sup> NK cells, as well as host defense during mouse CMV infection. The diminished function of Crk x CrkL-double-deficient NK cells correlated with decreased phosphorylation of STAT4 and STAT1 in response to IL-12 and IFN-α stimulation, respectively. Together, our findings analyzing NK cell-specific Crk-deficient mice provide insights into the role of Crk family proteins in NK cell function and host defense.
An efficient feedback method for MIMO systems with slowly time-varying channels (2004)

The capacity of a multiple-input multiple-output (MIMO) channel can be improved if the transmitter has a knowledge of the channel. In this paper, we propose an efficient and practical feedback method based on parameterization and quantization of channel parameters. The spatial information of the channel at the transmitter, which is represented as a matrix with orthonormal columns, has a geometrical structure. In parameterization, the geometrical structure is exploited to extract a set of parameters that has a one-to-one mapping to the original matrix. In slowly time-varying channels, the parameters are also found to he smoothly changing in time. We employ adaptive delta modulation to quantize and feed back each parameter. The results show that the proposed feedback scheme has a channel tracking feature and achieves a capacity very close to the perfect feedback case with a reasonable feedback rate.
Characterization of the short-term plasticity of the dentate gyrus-CA3 system using nonlinear systems analysis (2004)

Short-term plasticity (STP) have been traditionally studied using the paired impulse approach and the short impulse train approach. A new method for studying STP has been recently introduced [1], In this article, this method has been modified to take into account the varying amplitude of the input. It was then applied to the dentate gyrus-CA3 system. The system was studied at the population level using the population spike (PS) amplitude. Random impulse sequences (electrical shocks) with constant intensity were used to stimulate the afferents to the dentate gyrus (perforant path). Monosynaptic and disynaptic population spikes were recorded from the dentate gyrus and the CA3 regions respectively. The PS amplitude time series of the dentate gyrus formed the input dataset while the PS amplitude time series of the CAS region formed the output dataset. The data was analyzed using the Volterra Poisson approach leading to the estimation of the first and second order kernels, which formed comprehensive and quantitative descriptors of the nonlinear dynamics of STP in the CA3 hippocampal region.
Long-term (8 years) assessment of trastuzumab-related cardiac events in the HERA trial. (2013)

525 Background: Trastuzumab-related cardiac dysfunction may occur in patients (pts) treated with adjuvant therapy and it is mostly reversible. We report the long-term outcome of pts with cardiac dysfunction treated with adjuvant trastuzumab (T) in the Herceptin Adjuvant (HERA) trial. Methods: HERA is a three-arm, randomized trial that compared 1 year or 2 years of T with observation (Obs) in women with HER2-positive early breast cancer (EBC). Eligible pts had a left ventricular ejection fraction (LVEF) ≥ 55% at study entry (i.e. after completion of (neo)adjuvant chemotherapy with or without radiotherapy). Cardiac function was closely monitored throughout the trial. This analysis at 8-year median follow-up considers pts randomly assigned to 1 year or 2 years of T therapy or observation. Results: 5102 pts were randomized to HERA. The “as treated” safety population is considered: 2 years T (N=1,673), 1 year T (N=1,682) and Obs (N=1,744). Cardiac events leading to T discontinuation in the 1-year and 2-year arms were observed in 5.2% and 9.4% of pts, respectively. Cardiac death, severe congestive heart failure (CHF) and confirmed significant LVEF drop remained low in all three arms (Table). In the 1 year T arm, 71.4% of pts with severe CHF, and 81.2% of pts with confirmed LVEF drop recovered cardiac function (at least 2 sequential LVEF assessments &gt; 50%). The median time to recovery was 9.7 months and 6.3 months, respectively. In the 2 years T arm, 87.5% of pts with confirmed LVEF drop recovered cardiac function and median time to recovery was 8.3 months. Conclusions: At 8-year median follow-up the incidence of cardiac events during adjuvant T remains low and these events are mostly reversible. These results confirm low cardiac events when T is given as part of the adjuvant therapy for pts with HER2-positive EBC. Clinical trial information: NCT00045032. [Table: see text]
5.3.4 Introducing Innovative Technology in a Contract‐Driven Environment (2002)

Abstract This paper discusses our experiences in developing and introducing a web‐centric Collaborative Engineering Environment (CEE) into an organization whose lifeblood is performing on government contracts. We review events in the team's 3‐1/2 year history that led to an increasing awareness that the product development paradigm needed to introduce innovation into the engineering organization is very different from that needed to perform successfully on a contract. While many lessons from the world of contracting have been valuable, some of the disciplined processes learned over the course of many years, such as up front specification and traditional forms of progress tracking, can hinder innovation. Finally, we summarize the process adaptations we have made to address the conflicts.
An Episomally Maintained MDR1 Gene for Gene Therapy (2001)

Potential applications of the MDR1 multidrug transporter in gene therapy include protecting sensitive bone marrow cells against cytotoxic drugs during cancer chemotherapy and serving as a dominant selectable marker when coexpressed with a corrective passenger gene. To address safety concerns associated with integrating viral systems, such as retroviruses, we tested the feasibility of maintaining a nonvirally delivered MDR1 gene (pEpiHaMA) episomally. An MDR1 vector containing the Epstein-Barr virus (EBV) origin of replication (OriP) and its nuclear retention protein (EBNA-1) was transfected into human (KB-3-1) cells. MDR1 was expressed at a higher level in cells carrying the episomal vector, pEpiHaMA, compared with the vector lacking sequences needed for episomal maintenance (pHaMA). Furthermore, more drug-resistant KB-3-1 colonies were obtained on selection after transfection with pEpiHaMA. These observations correlated with longer maintenance of episomes in cells transfected with pEpiHaMA. In addition, episomes could still be recovered for more than 1 month from tumor explants in nude mice that were injected with pEpiHaMA-liposome complexes after drug selection, suggesting that these constructs can be maintained extrachromosomally in vivo.
Estimation of Dielectric Constant from CPE Parameters for Human Skin (2013)

Abstract not Available.
Valection: design optimization for validation and verification studies (2018)

Valection is implemented in multiple programming languages, available at: http://labs.oicr.on.ca/boutros-lab/software/valection.
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus (2021)

Diabetes mellitus is a complex disease. We are increasingly gaining a better understanding of its mechanisms at the molecular level. From these new insights, better therapeutic approaches should emerge. Diabetes mellitus is a syndrome with many associated subphenotypes. These include mitochondrial disorders, lipodystrophies, and inflammatory disorders involving cytokines. Levels of sphingosine-1-phosphate, which has recently been shown to play a role in glucose homeostasis, are low in diabetics, whereas levels of ceramides are increased. Major phenotypes associated with diabetes mellitus are dyslipidemias, notably hypertriglyceridemia and low high-density lipoprotein cholesterol levels. Both diabetes and dyslipidemia are strongly associated with increased risk for atherosclerotic vascular disease.
Synthesis and Polymerization of 2-Allylpyrrole (1973)

2-アリルピロール(2-AP)のラジカル共重合性およびフマロニトリル(FN)との交互共重合を検討する目的で,2-APの合成と重合を検討した。コモノマーのQ, e値と共重合性の間には一定の関係があり,コモノマーのQ,e値が大きいときは共重合,Q値が大きくe値が小さいときはコモノマーの単独重合,Q,e値ともに小さいときは重合禁止となった。さらに2-AP(M2)とアクリロニトリル(M1)との共重合では,モノマー反応性比としてr1=1.18±0.01,r2=O.05±O.01を得,Q2=0.07,e2=-0.40と計算された。また,FNとは電荷移動錯体を形成し(λmax=334nm,ニ塩化エチレン溶液),交互共重合する。そして,共重合速度極大はFN高濃度側に認められた。
High quality silicon-nitride thin films grown by helium plasma-enhanced chemical vapor deposition (2002)

Silicon nitride (SiN) films with very high dielectric strength of more than 8 MV/cm were successfully deposited on Si wafers using helium plasma-enhanced chemical vapor deposition (He-PECVD) at very low deposition temperature. The quality of the SiN films was much better than that of the SiN films deposited by the conventional PECVD. Silicon oxynitride (SiON) films with index of refraction varying from 1.46 to 2.0 were also deposited on Corning-7059 glass substrate by controlling the gas flow rate using computer process controller.
NK cells are primed by ANRS MVAHIV‐infected DCs, via a mechanism involving NKG2D and membrane‐bound IL‐15, to control HIV‐1 infection in CD4+T cells (2014)

Natural killer (NK) cells are the major antiviral effector cell population of the innate immune system. It has been demonstrated that NK-cell activity can be modulated by the interaction with dendritic cells (DCs). The HIV-1 vaccine candidate Modified Vaccinia Ankara encoding an HIV polypeptide (MVA(HIV)), developed by the French National Agency for Research on AIDS (ANRS), has the ability to prime NK cells to control HIV-1 infection in DCs. However, whether or not MVA(HIV)-primed NK cells are able to better control HIV-1 infection in CD4(+) T cells, and the mechanism underlying the specific priming, remain undetermined. In this study, we show that MVA(HIV)-primed NK cells display a greater capacity to control HIV-1 infection in autologous CD4(+) T cells. We also highlight the importance of NKG2D engagement on NK cells and DC-produced IL-15 to achieve the anti-HIV-1 specific priming, as blockade of either NKG2D or IL-15 during MVA(HIV)-priming lead to a subsequent decreased control of HIV-1 infection in autologous CD4(+) T cells. Furthermore, we show that the decreased control of HIV-1 infection in CD4(+) T cells might be due, at least in part, to the decreased expression of membrane-bound IL-15 (mbIL-15) on DCs when NKG2D is blocked during MVA(HIV)-priming of NK cells.
MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias (2018)

The genetically heterogeneous spinocerebellar ataxias (SCAs) are caused by Purkinje neuron dysfunction and degeneration, but their underlying pathological mechanisms remain elusive. The Src family of nonreceptor tyrosine kinases (SFK) are essential for nervous system homeostasis and are increasingly implicated in degenerative disease. Here we reveal that the SFK suppressor Missing-in-metastasis (MTSS1) is an ataxia locus that links multiple SCAs. MTSS1 loss results in increased SFK activity, reduced Purkinje neuron arborization, and low basal firing rates, followed by cell death. Surprisingly, mouse models for SCA1, SCA2, and SCA5 show elevated SFK activity, with SCA1 and SCA2 displaying dramatically reduced MTSS1 protein levels through reduced gene expression and protein translation, respectively. Treatment of each SCA model with a clinically approved Src inhibitor corrects Purkinje neuron basal firing and delays ataxia progression in MTSS1 mutants. Our results identify a common SCA therapeutic target and demonstrate a key role for MTSS1/SFK in Purkinje neuron survival and ataxia progression.
The Standardization of 5G-Advanced in 3GPP (2022)

The standardization of 5G in 3GPP is entering a second phase known as 5G-Advanced. The recent approval of Release 18 is based on a combination of features addressing immediate and longer-term needs. In this article, we present a comprehensive overview of Release 18 features by classifying them into three different categories: enhanced mobile broadband, vertical domain, and new areas. Evaluation results are provided to demonstrate the potential of 5G-Advanced.
A synergistic and extensible framework for multi-agent system verification (2013)

Recently there has been a proliferation of tools and languages for modeling multi-agent systems (MAS). Verification tools, correspondingly, have been developed to check properties of these systems. Most MAS verification tools, however, have their own input language and often specialize in one verification technology, or only support checking a specific type of property. In this work we present an extensible framework that leverages mainstream verification tools to successfully reason about various types of properties. We describe the verification of models specified in the Brahms agent modeling language to demonstrate the feasibility of our approach. We chose Brahms because it is used to model real instances of interactions between pilots, air-traffic controllers, and automated systems at NASA. Our framework takes as input a Brahms model along with a Java implementation of its semantics. We then use Java PathFinder to explore all possible behaviors of the model and, also, produce a generalized intermediate representation that encodes these behaviors. The intermediate representation is automatically transformed to the input language of mainstream model checkers, including PRISM, SPIN, and NuSMV allowing us to check different types of properties. We validate our approach on a model that contains key elements from the Air France Flight 447 accident.
Dual Damascene Interconnect Technology for 130-nm-node Complementary Metal–Oxide–Semiconductor Devices Using Ladder-Oxide Film (2003)

A 0.34-µm-pitch Cu dual damascene interconnect technology using a low-k ladder-oxide film (k=2.9) is developed for 130-nm-node complementary metal oxide semiconductor (CMOS) devices. Photoresist poisoning was improved by adopting the ladder-oxide film with annealing before the photolithography step. The fence structures around via openings caused poor Cu gap filling. The problem was solved by controlling the filling height of a bottom anti-reflective coating and by eliminating the photoresist poisoning. Furthermore, no degradation of the ladder-oxide film upon photoresist stripping was observed. It was demonstrated that these technologies could be applied to a product-level application-specific integrated circuit chip with a seven-level Cu interconnect.
BIOMIMETIC AEROGELS FROM MICROFIBRILLATED CELLULOSE AND XYLOGLUCAN (2009)

Cellulose aerogels with density of 7-100 kg/m3 were prepared by freeze drying from microfibrillated cellulose water suspensions, and biomimetic aerogels were prepared with the addition of xyloglucan. Their microstructures and physical properties were characterized by scanning electron microscopy, nitrogen adsorption measurements, and tensile tests.
<title>Seamless migration to VCSEL-based optical data links</title> (1997)

Applications for serial and parallel fiber optic data links are reviewed along with the barriers to widespread commercial adoption. An alternative migration path from copper to optical media, enabled by VCSEL technology, is investigated including initial performance results.
Abnormal Growth Hormone Response to TRH in Chronic Adolescent Schizophrenic Patients (1982)

Summary There was a significant rise in the human growth hormone response to intravenous thyrotropin releasing hormone in 5 of 10 chronic schizophrenic adolescents maintained on antipsychotic agents, but in none of 10 age and sex matched control subjects. In 4 of the 5 patients with growth hormone rise there was a positive family history of schizophrenia, but such a family history was obtained in only one of the non-responding schizophrenics.
A Solution to the Congestion Problem: Profiles Driven Trip Planning (2016)

Modern transportation systems suffer from a variety of problems. The most notable among these problems is traffic congestions. Traffic congestions have been a subject for much of research discussing the impact of the traffic on the environment, the financial cost it incurs, and the safety risks it poses. The research of this paper alternatively suggests a solution model to mitigate the congestion problem: the personalization of the trip planning process based on the social habits of the travellers. These habits can be derived from monitoring daily activities, calendar events, and social feeds from the various outlets of social media. The different sentiments of the travellers can be processed to generate several planning profiles. Travellers will be able to choose the profiles representing their personalities and subject them to further customization. The customized profile can be considered as an avatar. As the avatar assumes the traveller's planning persona, it will start to automatically plan the daily trips on behalf of the traveller. To fully grasp the functionality of the proposed approach, Game theory is used to analyze the new trip planning approach and its effect on the traffic flow.
The Chemistry of the Antibody Molecule (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Limited effects of polarization for Cl−(H2O)n and Na+(H2O)n clusters (1993)

Monte Carlo statistical mechanics simulations have been carried out for Cl− and Na+ in clusters of 1–14 water molecules. OPLS potential functions were used including the TIP4P model of water that do not include explicit polarization effects. In contrast to a prior report with the same potential functions, the computed enthalpies of binding for Cl− are shown to agree closely with experimental data, while the values for Na+ are about 10% too exothermic. The latter discrepancy is largely removed by using Aqvist’s Na+ parameters with TIP3P water. Moreover, the structures of the clusters show the expected nonspherical distribution of water molecules.
Robust Algorithms for Localizing Moving Nodes in Wireless Sensor Networks (2018)

The vivid success of the emerging wireless sensor technology (WSN) gave rise to the notion of localization in the communications field. Indeed, the interest in localization grew further with the proliferation of the wireless sensor network applications including medicine, military as well as transport. By utilizing a subset of sensor terminals, gathered data in a WSN can be both identified and correlated which helps in managing the nodes distributed throughout the network. In most scenarios presented in the literature, the nodes to be localized are often considered static. However, as we are heading towards the 5th generation mobile communication, the aspect of mobility should be regarded. Thus, the novelty of this research relies in its ability to merge the robotics as well as WSN fields creating a state of art for the localization of moving nodes. The challenging aspect relies in the capability of merging these two platforms in a way where the limitations of each is minimized as much as possible. A hybrid technique which combines both the Particle Filter (PF) method and the Time Difference of Arrival Technique (TDOA) is presented. Simulation results indicate that the proposed approach outperforms other techniques in terms of accuracy and robustness.
Extensive Macular Atrophy with Pseudodrusen in a Japanese Patient Evaluated by Wide-Field OCTA (2022)

Extensive macular atrophy with pseudodrusen (EMAP) is a relatively newly proposed clinical entity that was first reported in 2009. Although no definitive diagnostic criteria have been defined, characteristic findings can distinguish it from other diseases, especially dry age-related macular dystrophy (AMD). Herein, we present the case of a patient with EMAP who underwent a comprehensive ophthalmic examination and whole-exome sequencing (WES). A 72-year-old Japanese man complained of progressive visual impairment in his right eye and nyctalopia. Ophthalmic examination revealed that the best-corrected visual acuity (BCVA) in decimal units was 0.08 on the right and 0.8 on the left. Fundoscopy and fundus autofluorescence (FAF) revealed well-demarcated symmetrical macular atrophy, with a vertical axis larger than the horizontal axis, which reached the vascular arcade inferiorly and exceeded it superiorly. Pseudodrusen were widespread throughout the retina in both eyes. Paving-stone degeneration was not observed in the extreme periphery of either eye. Seven months later, his left BCVA decreased to 0.3 without major changes on multimodal imaging. Based on the above findings, we diagnosed EMAP. Wide-field optical coherence tomography angiography (OCTA) showed no significant changes in the retinal vessels, but the density of choroidal vessels was reduced in the degenerated areas. We thought that this finding suggests that EMAP originates between the deep retina and choroid. WES did not reveal any candidate mutations in known pathogenic genes. To the best of our knowledge, this is the first report of a Japanese patient with EMAP, and no data for analysis of wide-field OCTA or equatorial OCT images of EMAP cases have been found in previous reports. EMAP is not well recognized in Asia and may be incorrectly diagnosed as dry-type AMD. EMAP should be included in the differential diagnosis of dry AMD, and this may lead to more Asians being diagnosed with EMAP in the future.
[Effects of vascular peptide bioregulator on cerebral microcirculation of old hypertensive rats]. (2017)

Using a TV device to study brain microcirculation, we found that after a course of vascular peptide bioregulator the density of microvascular network of pia matter of old hypertensive rats (12 months) sensomotor cortex increased about 1,7 times compared to intact old rates SHR. This perfusion in the tissue of the cerebral cortex and the degree of blood oxygen saturation in the microvasculature of this tissue region raised.