gebhart/patrepeval huggingface dataset:
Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour (2011)

Responsive co-polymers based on polyethyleneglycol methacrylate (PEGMA) monomers have been grown by aqueous phase ATRP from a model protein, trypsin, to generate hybrid polymer-protein block conjugates. The conjugates (Hybrids I and II) both contained the same segment of grafted responsive co-polymer to afford a phase transition at 37 °C, Hybrid II however differed from Hybrid I by having a second block of hydrophilic pPEGMA monomer grown from the end of the responsive block. The resultant ‘diblock’ and ‘triblock’ hybrids were characterised in terms of their temperature-dependent behaviour in solution by dynamic light scattering, small-angle neutron scattering and pulsed-gradient spin-echo NMR, and their structures at surfaces examined by aqueous phase atomic force microscopy and cryo transmission electron microscopy. These data showed that Hybrids I and II differed in their solution behaviour with temperature, dependent on the arrangement of their grafted polymer blocks. Hybrid I self-assembled into higher-order structures above 37 °C before precipitating reversibly, whereas Hybrid II remained essentially constant in size across a similar temperature range even when its attached intermediate polymer block underwent a phase transition. The differences in polymer-protein hybrid behaviour were also manifest in enzyme activity assays with temperature-dependent hydrolysis of both peptide and protein substrates varying with hybrid architecture. Overall the data show that it is possible to grow responsive polymer-protein block co-polymers of varied structures, architectures and solution behaviour and that these can be used to control bioconjugate activity.
ChemInform Abstract: Synthesis and Crystal Structure of a Pentanuclear Heterometallic Acetylide Complex Cp2Mo2Ru3(CO)10(CCPh)2. (1990)

Abstract In the reaction of the acetylide (I) with Ru 3 (CO) 12 (II), beside the expected trinuclear acetylide derivative (III) and unreacted (II) the title complex (IV) is obtained (space group P2 1 /c, Z = 8).
220401 Evaluation of surface potential generation during CMP with EFM technique (2011)

Non-uniformity of surface potential affects the generation of various defects such as particle adhesion, residues, and corrosion, during CMP process. The surface potential is caused from many factors like work function differences, electrostatic charges, and charged particles. We evaluate the surface potential change during CMP process by using EFM (Electrostatic Force Microscope) technique. The surface potential change was observed on contaminated insulators by polishing with a Si probe. The potential shift was different from the kinds of insulators, which indicates that contamination layer exhibits different properties. The potential shift was also observed on cleaned (without contamination) insulators; this result indicates that mechanical deformation arises surface potential shift like the piezoelectric effect of ferroelectric materials such as PZT.
A quantitative and qualitative analysis of tensor decompositions on spatiotemporal data (2017)

With the recent explosion of systems capable of generating and storing large quantities of GPS data, there is an opportunity to develop novel techniques for analyzing and gaining meaningful insights into this spatiotemporal data. In this paper we examine the application of tensor decompositions, a high-dimensional data analysis technique, to georeferenced data sets. Guidance is provided on fitting spatiotemporal data into the tensor model and analyzing the results. We find that tensor decompositions provide insight and that future research into spatiotemporal tensor decompositions for pattern detection, clustering, and anomaly detection is warranted.
Unusual phase-pure zinc blende and highly-crystalline As-rich InAs1−xSbx nanowires for high-mobility transistors (2020)

Unusual phase-pure zinc blende and highly-crystalline As-rich InAs<sub>1−x</sub>Sb<sub>x</sub> nanowires with <italic>x</italic> &lt; 0.2 are successfully achieved for the fabrication of high-mobility transistors.
[Recent progress of thermoradiotherapy in cancer therapy]. (1995)

The recent progress of thermoradiotherapy for cancer is reviewed. Several biological methods for increasing the effects of heat on tumors have been developed, and some of them are being clinically investigated. Physical progress includes two new heating devices developed in Japan. One is an ultrasound heating system and the other is an intracavitary RF heating applicator in which simultaneous intracavitary irradiation is possible. The negative results of RTOG trial in USA caused a great impact in clinical hyperthermia. Careful analysis of this trial, however, demonstrated the advantages of the use of hyperthermia for those cases in which ther was good quality assurance of hyperthermia. Recent results of ESHO trials in Europe clearly demonstrated the superiority of thermoradiotherapy over radiotherapy alone for several tumors. Various site-specific clinical trials are expected to clarify the indications of thermoradiotherapy in future.
Effect of impurities and stress on the damage distributions of rapidly grown KDP crystals (1998)

Development of high damage threshold, 50 cm, rapidly grown KD*P frequency triplers for operation on the National Ignition Facility (NIF) in the 14 J/cm<SUP>2</SUP>, 351 nm, 3 ns regime requires a thorough understanding of how the crystal growth parameters and technologies affect laser induced damage. Of particular importance is determining the effect of ionic impurities which may be introduced in widely varying concentrations via the starting salts. In addition, organic particulates can contaminate the solution as leachants from growth platforms or via mechanical ablation. Mechanical stresses in the crystals may also play a strong role in the laser-induced damage distribution (LIDD), particularly in the case of large boules where hydrodynamic forces in the growth tank may be quite high. In order to investigate the effects of various impurities and stresses on laser damage we have developed a dedicated, automated damage test system with diagnostic capabilities specifically designed or measuring time resolved bulk damage onset and evolution. The data obtained makes it possible to construct characteristic damage threshold distributions for each samples. Test results obtained for a variety of DKP samples grown form high purity starting salts and individually doped with Lucite and Teflon, iron, chromium and aluminum show that the LIDD drops with increasing contamination content. The results also show that solution filtration leads to increased damage performance for undoped crystals but is not solely responsible for producing the high LIDDs required by the NIF. The highest LIDD measured on a rapidly grown sample indicate that it is possible to produce high damage threshold material using ultrahigh purity, recrystallized starting salts, continuous filtration and a platform designed to minimize internal stress during growth.
S2846 Liquid Nitrogen Cryoablation Alone Is an Effective Palliative Treatment for Metastatic Esophageal Squamous Cell Carcinoma (2022)

Introduction: In 2012, Esophageal squamous cell carcinoma (ESCC) was reported as the most common type of esophageal cancer in the world. In patients with metastatic ESCC, the mainstay of palliative management includes radiation therapy and esophageal stenting. Endoscopic cryoablation has emerged as a minimally invasive treatment for malignant esophageal neoplasm. The administration of liquid nitrogen, achieving a temperature of -85°C, causes transient tissue ischemia and recruitment of immune cells resulting in localized tissue destruction. Most preliminary studies assessing cryoablation in esophageal cancer have demonstrated symptomatic improvement in esophageal adenocarcinoma. Few studies have assessed the use of cryoablation in ESCC. A prospective study conducted in China demonstrated cryoablation’s ability to achieve complete remission in patients with moderate to high grade ESC neoplasm. Here we present a case utilizing endoscopic liquid nitrogen cryoablation as palliative therapy in a symptomatic patient with metastatic ESCC. Case Description/Methods: 82-year-old male former smoker with daily alcohol use presented with dysphagia and weight loss. CT scan of the chest revealed a mid-esophageal mass concerning for malignancy. Upper endoscopy demonstrated a large, fungating esophageal mass with partial obstruction (Figure A). Pathology revealed invasive poorly-differentiated ESCC. PET scan confirmed metastatic disease involving the right lung and paraesophageal, mediastinal, supraclavicular and right thoracic inlet lymph nodes. A multidisciplinary team offered palliative chemotherapy and radiation, which he declined. Due to worsening dysphagia and a 35lbs weight loss, he agreed to cryoablation (Figure B). He underwent an additional three sessions at two-months, three-months, and five-months for small areas of mucosal abnormalities (Figure C). He is four months out from treatment with improved dysphagia and stable weight. Discussion: This case report provides further evidence for the use of cryoablation alone as a minimally invasive, palliative intervention in patients with ESCC. Previous studies have highlighted the effectiveness of cryoablation in improving dysphagia and quality of life in symptomatic patients. This case report provides endoscopic evidence of cryoablation’s ability to reduce tumor burden and achieve complete remission in ESCC. Cryoablation alone appears to be a safe and well tolerated palliative treatment for patients with metastatic ESCC.Figure 1.: Upper endoscopic liquid nitrogen cryoablation of esophageal neoplasm. A) Initial upper endoscopy demonstrating large fungating mass in mid-esophagus with partial obstruction. B) Following completion of cryoablation treatment. C) Following three additional cryoablation sessions for treatment of residual disease.
Murine Type-C Virus Expression in Human × Mouse Hybrid Cells (1979)

Conference Article| April 01 1979 Murine Type-C Virus Expression in Human × Mouse Hybrid Cells STUART BROWN; STUART BROWN *Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, U.K. and National Cancer Institute-Veterans Administration, Washington, DC 20422, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar JOHN D. MINNA JOHN D. MINNA †National Cancer Institute-Veterans Administration Oncology Unit, Veterans Administration Hospital, Washington, DC 20422, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1979) 7 (2): 384–386. https://doi.org/10.1042/bst0070384 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation STUART BROWN, JOHN D. MINNA; Murine Type-C Virus Expression in Human × Mouse Hybrid Cells. Biochem Soc Trans 1 April 1979; 7 (2): 384–386. doi: https://doi.org/10.1042/bst0070384 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1979 Biochemical Society1979 Article PDF first page preview Close Modal You do not currently have access to this content.
Imaging of Proteins in Tissue Samples Using Nanospray Desorption Electrospray Ionization Mass Spectrometry (2015)

Chemical maps of tissue samples provide important information on biological processes therein. Recently, advances in tissue imaging have been achieved using ambient ionization techniques, such as desorption electrospray ionization mass spectrometry (DESI-MS), but such techniques have been almost exclusively confined to the mapping of lipids and metabolites. We report here the use of nanospray desorption electrospray ionization (nanoDESI) that allows us to image proteins in tissue samples in a label-free manner at atmospheric pressure with only minimum sample preparation. Multiply charged proteins with masses up to 15 kDa were successfully detected by nanoDESI using an LTQ Orbitrap mass spectrometer. In an adult mice brain section, expression of proteins including ubiquitin, β-thymosin, myelin basic protein, and hemoglobin were spatially mapped and characterized. We also determined the location of methylation on myelin basic protein. This imaging modality was further implemented to MYC-induced lymphomas. We observed an array of truncated proteins in the region where normal thymus cells were infiltrated by tumor cells, in contrast to healthy tissue.
Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia (2020)

Approximately 50% of acute myeloid leukemia (AML) patients do not respond to induction therapy (primary induction failure [PIF]) or relapse after <6 months (early relapse [ER]). We have recently shown an association between an immune-infiltrated tumor microenvironment (TME) and resistance to cytarabine-based chemotherapy but responsiveness to flotetuzumab, a bispecific DART antibody-based molecule to CD3ε and CD123. This paper reports the results of a multicenter, open-label, phase 1/2 study of flotetuzumab in 88 adults with relapsed/refractory AML: 42 in a dose-finding segment and 46 at the recommended phase 2 dose (RP2D) of 500 ng/kg per day. The most frequent adverse events were infusion-related reactions (IRRs)/cytokine release syndrome (CRS), largely grade 1-2. Stepwise dosing during week 1, pretreatment dexamethasone, prompt use of tocilizumab, and temporary dose reductions/interruptions successfully prevented severe IRR/CRS. Clinical benefit accrued to PIF/ER patients showing an immune-infiltrated TME. Among 30 PIF/ER patients treated at the RP2D, the complete remission (CR)/CR with partial hematological recovery (CRh) rate was 26.7%, with an overall response rate (CR/CRh/CR with incomplete hematological recovery) of 30.0%. In PIF/ER patients who achieved CR/CRh, median overall survival was 10.2 months (range, 1.87-27.27), with 6- and 12-month survival rates of 75% (95% confidence interval [CI], 0.450-1.05) and 50% (95% CI, 0.154-0.846). Bone marrow transcriptomic analysis showed that a parsimonious 10-gene signature predicted CRs to flotetuzumab (area under the receiver operating characteristic curve = 0.904 vs 0.672 for the European LeukemiaNet classifier). Flotetuzumab represents an innovative experimental approach associated with acceptable safety and encouraging evidence of activity in PIF/ER patients. This trial was registered at www.clinicaltrials.gov as #NCT02152956.
Bacterial endotoxin and non‐alcoholic fatty liver disease in the general population: a prospective cohort study (2015)

Endotoxin markers are associated with NAFLD in the general population, but do not have a major effect on NASH and fibrosis. People with modest alcohol consumption have lower serum endotoxin. This may partly explain the lower risk of NAFLD and NASH in modest drinkers in previous observational studies.
Latest Advances and Roadmap for In-Plane and Perpendicular STT-RAM (2011)

STT-RAM (Spin-Transfer Torque Random Access Memory) is a second-generation magnetic random access memory (MRAM) technology that is fast, non-volatile, durable, and scalable to future technology nodes [1-2]. In this paper, we present the latest advances in in-plane and perpendicular STT-RAM development and outline STT-RAM's future prospects, applications and roadmap.
Laser Emission from a Polymer‐Stabilized Liquid‐Crystalline Blue Phase (2005)

A molecularly assembled three-dimensional photonic crystal was prepared in the liquid-crystalline blue phase for organic solid-state laser applications (see Figure). The polymer network in the blue phase stabilized the laser operation over a temperature range 35 °C wide. Narrow laser emission, low threshold response, and circular polarization were measured due to the photonic-bandgap effect of the blue phase of the photonic crystal.
Conception de multicapteurs pour la mesure d’éthanol par perspiration cutanée (2016)

International audience
Characteristics of dotlike green satellite emission in GaInN light emitting diodes (2011)

An unwanted green satellite emission in blue GaInN light emitting diodes (LEDs) has been investigated under various electrical bias conditions and temperatures. The dot-shaped green satellite emission appears only under electrically biased conditions of the LED (but not under photoluminescence excitation) and contributes directly to a high subthreshold leakage current of the LED. A weak temperature dependency of the green satellite emission intensity is observed indicating that tunneling-assisted radiative recombination involving Mg acceptors is the origin of the green emission.
Enhanced light extraction from free-standing InGaN/GaN light emitters using bio-inspired backside surface structuring (2017)

Light extraction from InGaN/GaN-based multiple-quantum-well (MQW) light emitters is enhanced using a simple, scalable, and reproducible method to create hexagonally close-packed conical nano- and micro-scale features on the backside outcoupling surface. Colloidal lithography via Langmuir-Blodgett dip-coating using silica masks (d = 170-2530 nm) and Cl<sub>2</sub>/N<sub>2</sub>-based plasma etching produced features with aspect ratios of 3:1 on devices grown on semipolar GaN substrates. InGaN/GaN MQW structures were optically pumped at 266 nm and light extraction enhancement was quantified using angle-resolved photoluminescence. A 4.8-fold overall enhancement in light extraction (9-fold at normal incidence) relative to a flat outcoupling surface was achieved using a feature pitch of 2530 nm. This performance is on par with current photoelectrochemical (PEC) nitrogen-face roughening methods, which positions the technique as a strong alternative for backside structuring of c-plane devices. Also, because colloidal lithography functions independently of GaN crystal orientation, it is applicable to semipolar and nonpolar GaN devices, for which PEC roughening is ineffective.
A Prospective, Longitudinal Evaluation of SARS-CoV-2 COVID-19 Exposure, Use of Protective Equipment and Social Distancing in a Group of Community Physicians (2022)

Among a group of community physicians, consistent PPE use and social distancing practices were common. These practices were associated with a low level of initial acquisition of COVID-19 infections and a relatively low longitudinal risk of infection.
Conversion of Androgens to Estrogens in Idiopathic Hemochromatosis: Comparison with Alcoholic Liver Cirrhosis* (1985)

Hypogonadism is common in patients with some liver diseases, such as idiopathic hemochromatosis (IHC) and alcoholic cirrhosis (AC). However, gynecomastia, a typical feature in AC, does not occur in IHC. To determine the hormonal basis for this difference, the following parameters were determined in patients with IHC and AC as well as in normal men: plasma concentrations of androgens and estrogens, metabolic clearance and production rates of androstenedione and testosterone, and the contribution of peripheral conversion of androstenedione and testosterone to the circulating estrogens. Severe impotence in both patients with IHC and those with AC was associated with more than 50% reduction in plasma testosterone. The reduction was due to 63% and 70% decreases in testosterone production in IHC and AC, respectively. The MCRs were less affected in IHC and AC (19% and 37% reductions, respectively). In IHC, the fall in testosterone concentrations was accompanied by decreased production and plasma concentrations of androstenedione, a precursor for estrogen synthesis. In contrast, production and plasma concentrations of androstenedione were significantly increased in AC. Patients with IHC had estradiol und estrone levels similar to those in normal men (mean +/- SD, 16.2 +/- 4.6 vs. 20.3 +/- 3.7 pg/ml; P = NS), whereas in AC, estradiol and estrone were significantly elevated (38.0 +/- 5.3 and 68.5 +/- 17.2 pg/ml, respectively). In IHC, sex hormone-binding globulin levels were in the same range as in the normal men, whereas sex hormone-binding globulin was increased in AC. In IHC, the instantaneous contribution of plasma androstenedione to estrone and estradiol was normal, whereas that of plasma testosterone to plasma estrogens was decreased by about 50%. In contrast, in AC, the instantaneous contribution of plasma androstenedione to estrogens was greatly enhanced, and that of testosterone was in the normal range. Since the MCRs of androgens and the conversion ratios of androgens to estrogens indicate normal peripheral metabolism of sex hormones in IHC, decreased androgen formation implies decreased testicular synthesis. This was confirmed by a significantly decreased LH level in IHC (5.5 +/- 1.9 vs. 10.5 +/- 3.1 mU/ml in normal men), indicating pituitary failure. In AC, however, increased LH (20.0 +/- 2.7 mU/ml) may be indicative of primary testicular failure. These results confirm clinical features of hypogonadism and normal estrogenic activity in patients with IHC.(ABSTRACT TRUNCATED AT 250 WORDS)
A comparison of different experimental configurations in pulsed laser induced molecular fluorescence (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA comparison of different experimental configurations in pulsed laser induced molecular fluorescenceJ. H. Richardson and S. M. GeorgeCite this: Anal. Chem. 1978, 50, 4, 616–620Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ac50026a019https://doi.org/10.1021/ac50026a019research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cellular changes, protein and glycogen content in developing rabbit corpora lutea (1965)

Abstract The glycogen, protein and absolute cell numbers of the developing rabbit corpus luteum were measured from 24 hours to 192 hours after mating. There was no significant alteration in the protein content, which was approximately 9%. The glycogen content increased significantly from 0.14% at 24 hours to 0.26% at 120 hours and subsequently remained constant. The cell numbers were determined by homogenizing the tissue and the nuclei were counted in a Neubauer hemocytometer. The total cell numbers increased from 10 × 10 4 , of which 65% (6.3 × 10 4 ) were luteal cells, to 67 × 10 4 where 21% (9.8 × 10 4 ) were luteal cells. It was not determined whether the increase in luteal cells was due to mitotic division or transformation of the other cell types into luteal cells.
Isolation and characterization of ZnCH2 by Fourier transform I.R. matrix isolation spectroscopy and its photolytic rearrangement to HZnCH (1987)

The 1 : 1 adduct produced by cocondensing monoatomic zinc, diazomethane and argon onto a cold surface at 12 K can be converted to ZnCH2 with λ400 nm photolysis; a carbene→carbyne rearrangement of ZnCH2 to HZnCH is observed during u.v. photolysis.