gebhart/patrepeval huggingface dataset:
Augmentation of ventricular preload during treatment of cardiovascular collapse and cardiac arrest (2002)

Despite aggressive measures for the treatment of cardiovascular collapse and cardiac arrest, the hypotension associated with these malignant processes usually leads to profound vital-organ ischemia and death. A fundamental therapeutic challenge of such life-threatening processes is the restoration of adequate blood flow to the heart and the brain. However, to maintain adequate forward blood flow out of the heart, venous blood return must be drawn back into the heart. With the exception of administration of exogenous fluid replacement, there are limited ways to enhance blood flow back to the heart during prolonged hypotension. This article describes the potential value of a new impedance threshold valve for the treatment of cardiac arrest and hypotension. The valve was designed to create a vacuum within the thorax during the decompression phase of cardiopulmonary resuscitation or during inhalation. By transiently blocking inspiratory gas exchange during the decompression phase of cardiopulmonary resuscitation, after phrenic nerve-stimulated gasping, or during spontaneous ventilation, the impedance-valve concept may have clinical value in the treatment of patients in cardiac arrest, hemorrhagic shock, and cardiovascular collapse secondary to a number of life-threatening clinical processes.
Interionic Interactions in Imidazolium-Based Ionic Liquids: The Role of the C2-Position Revealed by Raman Scattering and Supported by IR and NMR Spectroscopy (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Kristina Noack, Natalia Paape, Johannes Kiefer, Peter Wasserscheid, Alfred Leipertz; Interionic Interactions in Imidazolium‐Based Ionic Liquids: The Role of the C2‐Position Revealed by Raman Scattering and Supported by IR and NMR Spectroscopy. AIP Conf. Proc. 6 August 2010; 1267 (1): 679–680. https://doi.org/10.1063/1.3482747 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate (2020)

This phase 1 study characterized the effect of multiple doses of upadacitinib, an oral Janus kinase 1 selective inhibitor, on the pharmacokinetics of the cytochrome P450 (CYP) 2B6 substrate bupropion. Healthy subjects (n = 22) received a single oral dose of bupropion 150 mg alone (study period 1) and on day 12 of a 16-day regimen of upadacitinib 30 mg once daily (study period 2). Serial blood samples for measurement of bupropion and hydroxybupropion plasma concentrations were collected in each study period. The central values (90% confidence intervals) for the ratios of change were 0.87 (0.79-0.96) for bupropion maximum plasma concentration (C<sub>max</sub> ), 0.92 (0.87-0.98) for bupropion area under the plasma-concentration time curve from time 0 to infinity (AUC<sub>inf</sub> ), 0.78 (0.72-0.85) for hydroxybupropion C<sub>max</sub> , and 0.72 (0.67-0.78) for hydroxybupropion AUC<sub>inf</sub> when administered with, relative to when administered without, upadacitinib. After multiple-dose administration of upadacitinib 30 mg once daily, upadacitinib mean ± SD AUC<sub>0-24</sub> was 641 ± 177 ng·h/mL, and C<sub>max</sub> was 83.3 ± 30.7 ng/mL. These results confirm that upadacitinib has no relevant effect on pharmacokinetics of substrates metabolized by CYP2B6.
Sequence analysis of the vir-region from Agrobacterium tumefaciens octopine Ti plasmid pTi15955 (2000)

The nucleotide sequence of 42 775 bp of the vir-region from the Agrobacterium tumefaciens octopine Ti plasmid pTi15955 is reported here. Although the nucleotide sequences of several parts of this region from this or closely related plasmids have been published previously, the present work establishes for the first time the complete arrangement of all the essential virulence genes and their intergenic regions of an octopine Ti plasmid. The disruption of some of the intergenic areas by insertion (IS) elements is typical for the octopine Ti plasmids. Several new ORFs were identified, including ORFs immediately downstream of virD4 and virE2, which probably represent new genes involved in virulence.
Data mining: machine learning, statistics, and databases (2002)

Knowledge discovery in databases and data mining aim at semiautomatic tools for the analysis of large data sets. We give an overview of the area and present some of the research issues, especially from the database angle.
Response of the border zone to myocardial infarction in rats. (1986)

The response of the surviving myocardium 30 days after coronary artery occlusion was measured morphometrically in the regions bordering and remote from infarcts of different sizes. Mean cell volume per nucleus increased with infarct size in both zones, but the rate of change was greater in the border than in the remote portion of the unaffected myocardium. Capillary numerical density within the uninjured tissue progressively decreased with infarct size leading to an increased diffusion distance for oxygen. Although the magnitude of changes in capillary density was similar in the two regions of the ventricle, the analysis of the individual values in each heart showed that in infarcts comprising more than 11% of the ventricular wall capillary concentration and the path length for oxygen supply to the myocytes were affected more in the border zone than in the myocardium remote from the scar. In conclusion, the border zone participates in the hypertrophic recovery process after infarction, but the inadequate growth of the capillary microvasculature suggests that this region is more susceptible to additional ischemic episodes.
Foreword: Special Issue on Statistics in Quality and Productivity (2014)

This special issue of Applied Stochastic Models in Business and Industry presents several papers that were presented at the 2013 Quality and Productivity Research Conference (QPRC) in Niskayuna, New York. The QPRC is an annual conference (held since 1984) sponsored by the Quality and Productivity Section of the American Statistical Association. Its mission is to improve the quality of products and services and the productivity of industries by stimulating the research and development of better statistical methods and to identify new application areas where statistics can have a significant impact. Additional information about QPRC can be found in the American Statistical Association Quality and Productivity community page, http://community.amstat.org/qp/meetings/qualityandproductivityresearchconference. The second paper by Dana C. Krueger and Douglas C. Montgomery presents an approach to modeling and analyzing semiconductor yield data. This modeling problem is of key importance in process and product management of semiconductor manufacturing operations, and its high complexity is related not only to massive data and presence of numerous failure types but also to intricate relationships between defects and product failures. The proposed approach based on Generalized Linear Mixed Models appears to have great potential. The third paper by Yingzhuo Fu and Daniel R. Jeske studies monitoring methods related to nonstationary correlated count data. These types of data are relevant in a large number of industrial applications—especially those related to quality assurance and process control. The authors focus on a particular application to the problem of network surveillance. The fourth paper, by Aleksey S. Polunchenko, Grigory Sokolov, and Wenyu Du, discusses performance evaluation of the Generalized Shiryaev–Roberts detection procedure. This type of analysis is of high importance for design and implementation of the relatively new Generalized Shiryaev–Robert procedures in practice. Finally, Scott Vander Wiel, Russell Bent, Emily Casleton, and Earl Lawrence introduce methodology for identification of downed lines in power grids based on data obtained from Phasor Measurement Units deployed at various parts of the network. We would like to express our profound gratitude to QPRC-2013 organizers and participants for the highly successful event and to authors, discussants, editors, and referees for their efforts on producing this special issue.
ChemInform Abstract: PREPARATION OF N‐AMINO‐(N′‐TERT‐BUTOXYCARBONYL)‐L‐PROLINE ESTERS AND ATTEMPTED CYCLIZATION INTO 1‐OXA‐4,5‐DIAZEPIN‐2‐ONES (1981)

Abstract Aus N‐Amino‐L‐prolin (Ia) werden die Ester (II) dargestellt.
Abstract 367: A Nox4 Inhibitor, GKT 137831, Decreases Aldosterone Synthesis, Adiposity and Vascular Contractility in a Murine Model of Diabetes. (2012)

Nox4 is expressed in many cell types including vascular cells and adipocytes. Expression of Nox4 is increased in cardiovascular diseases, such as hypertension and diabetes. Despite the advancement in the understanding of Nox4 biochemistry and its mechanisms of regulation, the pathophysiological role of Nox4 remains elusive and controversial. We recently demonstrated that adipocytes produce aldosterone, an effect that was exacerbated in diabetes and contributed to vascular dysfunction. Here we postulated that Nox4 plays a role on adipocyte-derived aldosterone production, leading to vascular dysfunction, during diabetes. Studies were performed in db/m (control) and db/db mice (a murine model of diabetes). Control and db/db mice were divided into 3 groups: Group 1, no treatment, Group 2, treatment with 20 mg (low dose) and Group 3, 60 mg (high dose) of GKT137831 (GKT) (Nox4 inhibitor) for 16 weeks. Blood pressure was measured by tail-cuff. Aldosterone (aldo) levels were measured in plasma and cell culture media from mature adipocytes extracted from all groups. Mesenteric arteries were obtained from all groups to study vascular responses to acetylcholine, a nitric oxide donor (DEA-NO) and norepinephrine (NE) by myography. Body weight was increased in db/db (61.8g ± 0.95) versus control (33.5g ± 0.72) mice, p&lt;0.05. GKT treatment did not alter body weight in db/m or db/db mice. Blood pressure levels were similar in all groups. Epididymal adiposity was increased in db/db mice (0.098g ± 0.16 vs. 0.067g ± 0.15, p&lt;0.05). Aldo levels were increased in plasma (pg/mL: 518 ± 67 vs. 272 ± 30, p&lt;0.05) and media from mature adipocytes (pg/mL/μg RNA: 1964 ± 213 vs. 388 ± 55, p&lt;0.001). GKT treatment (high dose) decreased adiposity (0.07g ± 0.05) and aldo levels in plasma (390 ± 41 pg/mL) and media from mature adipocytes (577 ± 91 pg/mL), p&lt;0.01. Endothelial dysfunction observed in db/db mice was not affected by GKT treatment. However, GKT treatment induced a decrease on NE-induced contraction in mesenteric arteries from db/db mice (pD2 values: db/db vs. db/db high dose, 6.4±0.1 vs. 5.6 ± 0.1, p&lt;0.001). Our findings suggest a role for Nox4 in adipocyte-derived aldo production and vascular reactivity in db/d mice. Such Nox4-related processes may be important in obesity-diabetes.
Optimization by a genetic algorithm of pyramidal structures made of one, two or three stacks of metal/dielectric layers for a quasi-perfect broadband absorption of UV to near-infrared radiations (2020)

We use a genetic algorithm to optimize 2-D periodic arrays of truncated square-based pyramids made of successive stacks of metal/dielectric layers. The objective is to achieve a quasi-perfect broadband absorption of normally incident radiations with wavelengths comprised between 420 and 1600 nm. We compare the results one can obtain by considering (i) Ni, Ti, Al or Cr for the metal, and (ii) poly(methyl methacrylate) (PMMA) or TiO<sub>2</sub> for the dielectric. The structures considered consist of only one, two or three stacks of each metal/dielectric combination. The absorption spectrum of these structures is calculated by a Rigorous Coupled Waves Analysis method. A genetic algorithm is then used to determine optimal values for the period of the system, the lateral dimensions of each stack of metal/dielectric and the width of each dielectric. The results show that Ni/PMMA represents the best metal/dielectric combination. With an optimized structure made of only three stacks of Ni/PMMA, it is possible indeed to absorb 99.8% of the considered incident radiations. An integrated absorptance of 99.4% is achieved with three stacks of Ti/PMMA or Cr/PMMA. Aluminium is not to recommend for this application. The solutions obtained with this metal are indeed too sensitive on the geometrical parameters of the system.
Fabrication of High Capacitance Density Capacitor Using Spray Coated Ba0.6Sr0.4TiO3 Thin Films (2018)

The integration of decoupling capacitors with high capacitance density on interposers for 3D electronics packaging requires innovative approaches for dielectric layer deposition. In this paper, we report the development of a novel and low-cost spray coating technique for the fabrication of thin film metal-insulator-metal (MIM) capacitors. We focus on thin films based on Ba <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</sub> Sr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.4</sub> TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> nanoparticles synthetized using the continuous and scalable supercritical fluid process. The obtained capacitance density agrees with the state-of-the art and a reduction of the leakage current is achievable by grafting specific ligands on the nanoparticle surface. Despite the presence of leakage current which must be still optimized, the overall performance is promising for 3D electronic packaging.
ChemInform Abstract: Convergent Approaches to the Vitamin D Skeleton Using a Transition Metal Catalyzed Carbometalation/Capture Strategy. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimization of the fragmentation in a frit-fast atom bombardment ion source for the sequencing of peptides at the picomole level (1991)

Peptides derived from enzymatic digestions (cathepsin D and trypsin) were characterized and amino acid sequences determined by using their LC/MS spectra. A Frit-FAB interface that produces extensive peptide fragmentation and permits amino acid sequencing at the low picomole level is described for a model antigen, Staphylococcus aureus nuclease (Nase), and an enzyme of unknown structure, yeast aminopeptidase B. The amino acid sequences of peptides derived from digestion of Nase with cathepsin D (a relatively nonspecific endoprotease) were readily deduced and have provided insights into the nature of antigen processing. Frit-FAB LC/MS spectra of the Nase peptides contained a sufficient number of fragment ions to conclusively identify peptides with a mass below 2000 Da. Capillary LC/MS provided a means for the separation and identification of these enzymatically derived peptides in a fraction of the time that would have been required by gas-phase Edman sequence analysis. The optimized Frit-FAB experiment was consequently evaluated for the partial characterization of aminopeptidase B recently purified to homogeneity from Saccharomyces cerevisiae. Sequence-specific ions observed in the Frit-FAB mass spectra of these tryptic peptides were identical with those commonly observed in high-energy collision-induced dissociation (CID) spectra and included side-chain fragment ions that differentiated leucine from isoleucine. These fragment ions were used to deduce entire amino acid sequences for several of the tryptic peptides.
Discovery of a Selective, State-Independent Inhibitor of Na V 1.7 by Modification of Guanidinium Toxins (2019)

Abstract The voltage-gated sodium channel isoform Na V 1.7 is highly expressed in small diameter dorsal root ganglion neurons and is obligatory for nociceptive signal transmission. Genetic gain-of-function and loss-of-function Na V 1.7 mutations have been identified in select individuals, and are associated with episodic extreme pain disorders and insensitivity to pain, respectively. These findings implicate Na V 1.7 as a key pharmacotherapeutic target for the treatment of pain. While several small molecules targeting Na V 1.7 have been advanced to clinical development, no Na V 1.7-selective compound has shown convincing efficacy in clinical pain applications. Here we describe the discovery and characterization of ST-2262, a Na V 1.7 inhibitor that blocks the extracellular vestibule of the channel with an IC 50 of 72 nM and greater than 200-fold selectivity over off-target sodium channel isoforms, Na V 1.1–1.6 and Na V 1.8. In contrast to other Na V 1.7 inhibitors that preferentially inhibit the inactivated state of the channel, ST-2262 is equipotent against resting and inactivated protein conformers. In a non-human primate model, animals treated with ST-2262 exhibit markedly reduced sensitivity to noxious heat. These findings establish the extracellular vestibule of the sodium channel as a viable receptor site for selective ligand design and provide insight into the pharmacology of state-independent inhibition of Na V 1.7. Significance Statement Pain is among the most common reasons for seeking medical care, yet many frequently prescribed drugs, particularly the opioids, cause problematic side effects and carry a risk of addiction. Voltage-gated sodium ion channels (Na V s) have emerged as promising targets for the development of non-opioid pain medicines. Na V s are involved in the propagation of electrical signals along neurons throughout the body. Humans born without a functional copy of one sodium channel subtype, Na V 1.7, are unable to experience most types of pain. In the present work, we disclose the discovery and characterization of a selective inhibitor of Na V 1.7 that reduces sensitivity to a painful thermal stimulus in non-human primates. Findings from this work may help guide the development of novel, non-addictive drug candidates as alternatives to opioids.
Analysis of cooperativity and ion effects in the interaction of quinacrine with DNA (1980)

Na+]." For example, Eq.
Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. III. Role of the MLC-stimulating cell population in alpha-fetoprotein-induced suppression of T cell-mediated cytotoxicity. (1982)

Alpha-fetoprotein (AFP), a normal component of fetal and newborn sera, exerts selective suppressive effects on various functions of thymus-derived (T) lymphocytes, including the T cell-mediated cytotoxic reaction. In the present study, AFP-induced suppression of the T cell-mediated allogeneic response was examined to define more precisely the mechanism by which AFP acts. Data presented indicate that AFP elicits its effect within the first 25 to 36 hr of culture. However, AFP apparently has no direct effect on T lymphocytes. T cells incubated in the presence of AFP retain full capacity to respond in MLC and CML. In contrast, AFP induces major changes in the functional status of monocyte-enriched, MLC-stimulating cell population. This monocyte-enriched population, after pretreatment with AFP, possesses strong stimulating capacity for the T suppressor cell limb of the immune response, while at the same time, suppresses the activity leading to the normal generation of cytotoxic T lymphocytes. These data correlate with the immune activity present in the newborn mouse.
Active current control in wind power plants during grid faults (2010)

Abstract Modern wind power plants are required and designed to ride through faults in electrical networks, subject to fault clearing. Wind turbine fault current contribution is required from most countries with a high amount of wind power penetration. In order to comply with such grid code requirements, wind turbines usually have solutions that enable the turbines to control the generation of reactive power during faults. This paper addresses the importance of using an optimal injection of active current during faults in order to fulfil these grid codes. This is of relevant importance for severe faults, causing low voltages at the point of common coupling. As a consequence, a new wind turbine current controller for operation during faults is proposed. It is shown that to achieve the maximum transfer of reactive current at the point of common coupling, a strategy for optimal setting of the active current is needed. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Air-Cooled Thermosyphon for Press-Pack Stack of Semiconductors (2016)

Medium voltage converters make extensive use of press-pack semiconductors in several products ranging from drives to rectifiers. Better cooling brings significant advantages: the possibility of drawing more power using the same semiconductors and thus effectively extending the converter operating range, a higher reliability, and cost savings on semiconductors for equal converter power. In this article, the experimental characterization of a baseplate to air thermosyphon for the double-side cooling of press pack thyristor modules in presented. Effects of refrigerant fluid filling, heat load, air temperature and air flow on the junction temperature were studied in both vertical and horizontal stack configuration. Vertical evaporator yields the best performance with 120°C junction temperature at 40°C air and 30W/cm2 heat loss.
Treatment Philosophy and Retreatment Rates Following Piezoelectric Lithotripsy (1993)

Second generation lithotriptors offer the advantage of anesthesia-free fragmentation of renal and ureteral calculi but they frequently require multiple treatments to attain a stone-free status. However, excessive single lithotripsy sessions or multiple treatments may be associated with significant damage to the kidney. For some clinicians a common treatment philosophy involves evaluation of serial plain abdominal films every 24 hours after lithotripsy and immediate retreatment of all patients with incomplete fragmentation. To avoid unnecessary retreatments and, thus, minimize potential renal damage, we prospectively evaluated 100 patients undergoing lithotripsy on a Wolf Piezolith 2300 device. Patients were routinely treated with 4,000 shocks at 1,100 bar. Serial plain abdominal films were obtained at 1 day and 2 weeks after lithotripsy. The need for retreatment was determined by the plain abdominal film results. Additional therapy was considered necessary if there was no stone fragmentation or if residual fragments measured greater than 4 mm. Of the patients whose plain abdominal film at 24 hours indicated the need for a repeat treatment 43% were stone-free on the 2-week film. Thus, these patients were spared an unnecessary treatment by allowing adequate time for the stone fragments to pass spontaneously. Our data suggest that repeat treatments on second generation lithotriptors should not be performed within 24 hours. Rather, the patient should be reevaluated at least 1 to 2 weeks later to avoid unnecessary retreatment with the attendant potential for renal injury. In addition, when comparing the retreatment rates of various lithotriptors, one should also consider the treatment philosophy used at the particular institution and the timing of the radiographic studies used to determine the stone-free status.