gebhart/patrepeval huggingface dataset:
Approximation and collusion in multicast cost sharing (extended abstract) (2001)

Article Share on Approximation and collusion in multicast cost sharing (extended abstract) Authors: J. Feigenbaum Yale University, New Haven, CT Yale University, New Haven, CTView Profile , A. Krishnamurthy Yale University, New Haven, CT Yale University, New Haven, CTView Profile , R. Sami Yale University, New Haven, CT Yale University, New Haven, CTView Profile , S. Shenker ACIRI/ICSI, Berkeley, CA ACIRI/ICSI, Berkeley, CAView Profile Authors Info & Claims EC '01: Proceedings of the 3rd ACM conference on Electronic CommerceOctober 2001 Pages 253–255https://doi.org/10.1145/501158.501190Online:14 October 2001Publication History 9citation174DownloadsMetricsTotal Citations9Total Downloads174Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Overlay mark optimization using the KTD signal simulation system (2009)

As the overlay performance and accuracy requirements become tighter, the impact of process parameters on the target signal becomes more significant. Traditionally, in order to choose the optimum overlay target, several candidates are placed in the kerf area. The candidate targets are tested under different process conditions, before the target to be used in mass production is selected. The varieties of targets are left on the mass production mask and although they will not be used for overlay measurements they still consume kerf real estate. To improve the efficiency of the process we are proposing the KTD (KLA-Tencor Target Designer). It is an easy to use system that enables the user to select the optimum target based on advanced signal simulation. Implementing the KTD in production is expected to save 30% of kerf real estate due to more efficient target design process as well as reduced engineering time. In this work we demonstrate the capability of the KTD to simulate the Archer signal in the context of advanced DRAM processes. For several stacks we are comparing simulated target signals with the Archer100 signals. We demonstrate the robustness feature in the KTD application that enables the user to test the target sensitivity to process changes. The results indicate the benefit of using KTD in the target optimization process.
High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets (2006)

A high-performance flow-focusing geometry for spontaneous generation of monodispersed droplets is demonstrated. In this geometry, a two-phase flow is forced through a circular orifice integrated inside a silicon-based microchannel. The orifice with its cusp-like edge exerts a ring of maximized stress around the flow and ensures controlled breakup of droplets for a wide range of flow rates, forming highly periodic and reproducible dispersions. The droplet generation can be remarkably rapid, exceeding 10(4) s(-1) for water-in-oil droplets and reaching 10(3) s(-1) for oil-in-water droplets, being largely controlled by flow rate of the continuous phase. The droplet diameter and generation frequency are compared against a quasi-equilibrium model based on the critical Capillary number. The droplets are obtained despite the low Capillary number, below the critical value identified by the ratio of viscosities between the two phases and simple shear-flow.
Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A–Dependent Neoangiogenesis (2009)

Blood vessel formation is controlled by the balance between pro- and antiangiogenic pathways. Although much is known about the factors that drive sprouting of neovessels, the factors that stabilize and pattern neovessels are undefined. The expression of angiomodulin (AGM), a vascular endothelial growth factor (VEGF)-A binding protein, was increased in the vasculature of several human tumors as compared to normal tissue, raising the hypothesis that AGM may modulate VEGF-A-dependent vascular patterning. To elucidate the expression pattern of AGM, we developed an AGM knockin reporter mouse (AGM(lacZ/+)), with which we demonstrate that AGM is predominantly expressed in the vasculature of developing embryos and adult organs. During physiological and pathological angiogenesis, AGM is upregulated in the angiogenic vasculature. Using the zebrafish model, we found that AGM is restricted to developing vasculature by 17 to 22 hours postfertilization. Blockade of AGM activity with morpholino oligomers results in prominent angiogenesis defects in vascular sprouting and remodeling. Concurrent knockdown of both AGM and VEGF-A results in synergistic angiogenesis defects. When VEGF-A is overexpressed, the compensatory induction of the VEGF-A receptor, VEGFR2/flk-1, is blocked by the simultaneous injection of AGM morpholino oligomers. These results demonstrate that the vascular-specific marker AGM modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A.
Carbon Nanofiber Synthesis within 3-Dimensional Sintered Nickel Microfibrous Matrices: Optimization of Synthesis Conditions (2012)

This study focuses on the process of optimization for carbon nanofiber synthesis at the exterior and the interior of 3-dimensional sintered nickel microfibrous networks. Synthesis of carbon nanofibers (CNF) by catalytic decomposition of acetylene (ethyne) was conducted at atmospheric pressure and short reaction times (10 min). Two factors evaluated during the study were (a) CNF quality (observed by SEM and Raman spectroscopy) and (b) rate of reaction (gravimetrically measured carbon yield). Independent optimization variables included redox faceting pretreatment of nickel, synthesis temperature, and gas composition. Faceting resulted in an 8-fold increase in the carbon yield compared to an untreated substrate. Synthesis with varying levels of hydrogen maximized the carbon yield (9.31 mg C/cm 2 catalyst). The quality of CNF was enhanced via a reduction in amorphous carbon that resulted from the addition of 20% ammonia. Optimized growth conditions that led to high rates of CNF deposition preferentially deposited this carbon at the exterior layer of the nickel microfibrous networks (570°C, 78% H 2 , 20% NH 3 , 2% C 2 H 2 , faceted Ni.). CNF growth within the 3-dimensional nickel networks was accomplished at the conditions selected to lower the gravimetric reaction rate (470°C, 10% H 2 , 88% N 2 , 2% C 2 H 2 , nonfaceted Ni).
Semi-Active Suspension Control on Bicycles: Anti-Dive during Road Excitation (2019)

Suspension systems on bicycles have a tendency to severe brake-induced dive-in, caused by the small wheelbase in combination with a high center of gravity. Semi-active dampers allow the implementation of anti-dive functionality, preventing this behavior. Experimental analysis has shown that this yields significant advantages during brake control on level surfaces. In the presence of additional road excitation, however, a strong conflict arises. A specific test case is a bump occurring while braking, when the damping is set to the hardest value in order to mitigate dive-in. A simulative analysis illustrates that especially the dynamic wheel load is affected, which during braking is safety critical. By simulation and experimental implementation it is shown that using a simple semi-active control rule a decent trade-off can be found. Finally, the influence of the actuator response time is evaluated.
Background-Free Second-Harmonic Generation Microscopy of Individual Carbon Nanotubes (2015)

We use polarized second-harmonic generation (SHG) microscopy to investigate pristine air-suspended carbon nanotubes (CNT). We show that SHG originates from CNT chirality, allowing also different response for the two circular polarizations of fundamental light.
<title>Radar image understanding for complex space objects</title> (1991)

A system for identifying complex space objects from a sequence of wideband radar images is presented in this paper. The system is referred to as the Complex Space Object Recognition System (CSORS) and uses a data-driven approach to object recognition. The input to the system is a time sequence of range/Doppler radar images of an object in orbit as the object passes overhead. The system first processes the individual images to improve the signal-to-noise-ratio and then further processes each image to derive a set of features. The sequence of feature sets for each pass of the object is then processed to produce a three-dimensional wireframe of the object. Finally, a symbolic model representing the object is generated from the wireframe. This model is matched against a library of models and appended to the library if a match is not found.
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations (2011)

Sunitinib, an oral tyrosine kinase inhibitor approved to treat advanced renal cell carcinoma and gastrointestinal stroma tumor, is associated with clinical cardiac toxicity. Although the precise mechanism of sunitinib cardiotoxicity is not known, both the key metabolic energy regulator, AMP-activated protein kinase (AMPK), and ribosomal S 6 kinase (RSK) have been hypothesized as causative, albeit based on rodent models. To study the mechanism of sunitinib-mediated cardiotoxicity in a human model, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) having electrophysiological and contractile properties of native cardiac tissue were investigated. Sunitinib was cardiotoxic in a dose-dependent manner with an IC₅₀ in the low micromolar range, observed by a loss of cellular ATP, an increase in oxidized glutathione, and induction of apoptosis in iPSC-CMs. Pretreatment of iPSC-CMs with AMPK activators AICAR or metformin, increased the phosphorylation of pAMPK-T172 and pACC-S79, but only marginally attenuated sunitinib mediated cell death. Furthermore, additional inhibitors of AMPK were not directly cytotoxic to iPSC-CMs up to 250 μM concentrations. Inhibition of RSK with a highly specific, irreversible, small molecule inhibitor (RSK-FMK-MEA) did not induce cytotoxicity in iPSC-CMs below 250 μM. Extensive electrophysiological analysis of sunitinib and RSK-FMK-MEA mediated conduction effects were performed. Taken together, these findings suggest that inhibition of AMPK and RSK are not a major component of sunitinib-induced cardiotoxicity. Although the exact mechanism of cardiotoxicity of sunitinib is not known, it is likely due to inhibition of multiple kinases simultaneously. These data highlight the utility of human iPSC-CMs in investigating the potential molecular mechanisms underlying drug-induced cardiotoxicity.
Assembly of Linked Nanocrystal Colloids by Reversible Covalent Bonds (2020)

The use of dynamically bonded molecules designed to reversibly link solvent-dispersed nanocrystals (NCs) is a promising strategy to form colloidal assemblies with controlled structures and macroscopic properties. In this work, tin-doped indium oxide NCs are functionalized with ligands that form reversible covalent bonds with linking molecules to drive assembly of NC gels. We monitor the gelation by using small angle X-ray scattering and characterize how changes in the gel structure affect the infrared optical properties arising from the localized surface plasmon resonance of the NCs. The assembly is reversible because of the designed linking chemistry, and we disassemble the gels using two strategies: addition of excess NCs to change the ratio of linking molecules to NCs and addition of a capping molecule that displaces the linking molecules. The assembly behavior is rationalized using a thermodynamic perturbation theory to compute the phase diagram of the NC–linking molecule mixture. Coarse-grained molecular dynamics simulations reveal the competition between the loop and bridge linking motifs essential for understanding NC gelation. This combined experimental, computational, and theoretical work provides a platform for controlling and designing the properties of reversible colloidal assemblies that incorporate NC and solvent compositions beyond those compatible with other contemporary (e.g., DNA-based) linking strategies.
UWB Sparse/Diffuse Channels, Part I: Channel Models and Bayesian Estimators (2012)

In this two-part paper, the problem of channel estimation in Ultra Wide-Band (UWB) systems is investigated. Due to the large transmission bandwidth, the channel has been traditionally modeled as sparse. However, some propagation phenomena, e.g., scattering from rough surfaces and frequency distortion, are better modeled by a diffuse channel. Herein, a novel Hybrid Sparse/Diffuse (HSD) channel model is proposed. Tailored to the HSD model, channel estimators are designed for different scenarios that vary in the amount of side information available at the receiver. An Expectation-Maximization algorithm to estimate the power delay profile of the diffuse component is also designed. The proposed methods are compared to unstructured and purely sparse estimators. The numerical results show that the HSD estimation schemes considerably improve the estimation accuracy and the bit error rate performance over conventional channel estimators. In Part II, the new channel estimators are evaluated with more realistic geometry-based channel emulators. The numerical results show that, even when the channel is generated in this manner, the new estimation strategies achieve high performance. Moreover, a Mean-Squared Error analysis of the proposed estimators is performed, in the high and low Signal to Noise Ratio regimes, thus quantifying, in closed form, the achievable performance gains.
Isomer-specific comparisons of the hydrolysis of synthetic pyrethroids and their fluorogenic analogues by esterases from the cotton bollworm Helicoverpa armigera (2014)

The low aqueous solubility and chiral complexity of synthetic pyrethroids, together with large differences between isomers in their insecticidal potency, have hindered the development of meaningful assays of their metabolism and metabolic resistance to them. To overcome these problems, Shan and Hammock (2001) [7] therefore developed fluorogenic and more water-soluble analogues of all the individual isomers of the commonly used Type 2 pyrethroids, cypermethrin and fenvalerate. The analogues have now been used in several studies of esterase-based metabolism and metabolic resistance. Here we test the validity of these analogues by quantitatively comparing their hydrolysis by a battery of 22 heterologously expressed insect esterases with the hydrolysis of the corresponding pyrethroid isomers by these esterases in an HPLC assay recently developed by Teese et al. (2013) [14]. We find a strong, albeit not complete, correlation (r = 0.7) between rates for the two sets of substrates. The three most potent isomers tested were all relatively slowly degraded in both sets of data but three esterases previously associated with pyrethroid resistance in Helicoverpa armigera did not show higher activities for these isomers than did allelic enzymes derived from susceptible H. armigera. Given their amenability to continuous assays at low substrate concentrations in microplate format, and ready detection of product, we endorse the ongoing utility of the analogues in many metabolic studies of pyrethroids.
ChemInform Abstract: Unsymmetrical Functionalization of 1,3‐Cyclohexadienes: Palladium‐Catalyzed Stereoselective 1,4‐Acyloxy‐alkoxylation. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Full-Mesh Optical Backplane with Modular Fiber Ribbon-based Sub-Circuits (2016)

A modular, scalable and full-mesh bandwidth-upgradable optical interconnection between optoelectronic boards is guaranteed thanks to an optimized layout of standard MM fiber ribbons which divides the overall backplane into independent optical sub-circuits.
An Axial Output Relativistic Magnetron Fed by a Split Cathode and Magnetically Insulated by a Low-Power Solenoid (2021)

One of the main difficulties in designing a relativistic magnetron producing high-power microwaves (HPMs) to be compact, is the power source required to feed the solenoid producing the axial magnetic field, which magnetically insulates the electron beam. This is because the diffusion of the magnetic field through the walls of the system is on the millisecond timescale. The latter requires high-power supplies and restricts the magnetron from operating repetitively. Using permanent magnets instead does not make the system sufficiently compact, because of the size and weight of the magnets and does not allow varying the magnetic field. We suggest a simple solution to this problem by cutting longitudinal slits through the entire magnetron anode system. With such slits, the magnetic field penetration is not restricted by the diffusion rate. Thus, one can apply a microsecond-timescale magnetic field produced by a solenoid powered by a considerably smaller power supply. We test this idea by using particle-in-cell (PIC) simulations of a magnetron for the axial output design suggested by Xu <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">et al.</i> (2018) fed by a split cathode (Leopold <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">et al.</i> , 2020). With a split cathode, the second major problem with relativistic magnetrons is alleviated—pulse shortening is avoided.
Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations (1997)

Cross-links between cellulose microfibrils and xyloglucan (XG) molecules play a major role in defining the structural properties of plant cell walls and the regulation of growth and development of dicotyledonous plants. How these cross-links are established and how they are regulated has yet to be determined. In a previous study, preliminary data were presented which suggested that the different sidechains of XG may play a role in controlling cellulose microfibril-XG interactions. In this study, this question is addressed directly by analyzing to what extent the different sidechains of pea cell wall XG and nasturtium seed storage XG affect their binding to cellulose microfibrils. Of particular importance to this study are the chemical data indicating that pea XG possesses a trisaccharide sidechain, which is not found in nasturtium XG. To this end, conformational dynamic simulations have been used to predict whether oligosaccharides representative of pea and nasturtium XG can adopt a hypothesized cellulose-binding conformation and which of these XGs exhibits a preferential ability to bind cellulose. Extensive analysis of the conformational forms populated during 300 K and high-temperature Monte Carlo simulations established that a planar, sterically accessible, glucan backbone is essential for optimal cellulose-binding. For the trisaccharide sidechain-containing oligosaccharide as found in pea XG, sidechain orientation appeared to regulate the gradual acquisition of this hypothesized cellulose binding conformation. Thus, conformational forms were identified that included the twisted backbone (non-planar) putative solution form of XG, forms in which the trisaccharide sidechain orientation enables increased backbone planarity and steric accessibility, and finally a planar, sterically accessible, backbone. By applying these conformational requirements for cellulose binding, it has been determined that pea XG possesses a two- to threefold occurrence of the cellulose binding conformation than nasturtium XG. Based on this finding, it was predicted that pea XG would bind to cellulose at a higher rate than nasturtium XG. In vitro binding assays showed that pea XG-avicel binding does indeed occur at a twofold higher rate than nasturtium XG-avicel binding. The enhanced ability of pea cell wall XG over nasturtium seed storage XG to associate with cellulose is consistent with a structural role of the former during epicotyl growth where efficient association with cellulose is a requirement. In contrast, the relatively low ability of nasturtium XG to bind cellulose is consistent with the need to enhance the accessibility of this polymer to glycanases during germination. These findings suggest potential roles for XG sidechain substitution, enabling XG to function in a variety of different biological contexts.
Non-systematic RS encoder design for a parity replacer of ATSC-M/H system (2010)

An efficient RS encoder for a parity replacer circuit of ATSC M/H mobile DTV receiver is presented. First, we derive the non-systematic RS encoder architecture which requires the well-known Forney algorithm to evaluate the parity symbol values located at arbitrary positions. We notice that only at most three information symbols corresponding to the trellis initialization symbol determine the RS parity symbols to be replaced in the parity replacer circuit. So we derive another form of the Forney algorithm to represent the parity symbol value as a linear combination of the input information symbols. With the new form, efficient architecture for implementing the RS encoder of a parity replacer is presented.
Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo (2014)

A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle-forming materials was produced wherein the free amines on multigenerational poly(amido amine) and poly(propylenimine) dendrimers were substituted with alkyl chains of increasing length, and evaluated for their ability to deliver siRNA to liver cell subpopulations. Interestingly, two lead delivery materials could be formulated in a manner to alter their tissue tropism within the liver-with formulations from the same material capable of preferentially delivering siRNA to 1) endothelial cells, 2) endothelial cells and hepatocytes, or 3) endothelial cells, hepatocytes, and tumor cells in vivo. The ability to broaden or narrow the cellular destination of siRNA within the liver may provide a useful tool to address a range of liver diseases.
Selegiline in the Treatment of Sexual Dysfunction in Schizophrenic Patients Maintained on Neuroleptics: A Pilot Study (2003)

A double-blind, placebo-controlled crossover study was undertaken in 10 neuroleptic-treated male schizophrenic outpatients to assess the effect of coadministration of selegiline 15 mg/day for 3 weeks on their sexual dysfunction. Selegiline was not found to be effective in improving any domain of sexual functioning despite a significant decrease in prolactin levels (P < 0.05). This study emphasizes the complex nature of sexual dysfunction in schizophrenic-treated patients and the need for placebo-controlled trials for this condition.