gebhart/patrepeval huggingface dataset:
Aided System for Visually Impaired People in Bus Transport using Intel Galileo Gen-2: Technical Note (2017)

Outwardly impeded individuals experience issues in travel and getting to data about open transportation frameworks. A few frameworks have been created for encouraging outwardly hindered utilizing the city transport. Most frameworks give double way correspondence and require expensive and complex hardware. The objective of this work is to decrease the troubles confronted by outwardly debilitated individuals while boarding in city transports, utilizing an intuitive remote correspondence framework. The framework contained a client module and a transport module to give an immediate coordinated association to diminish the existing challenges with a new many-to-numerous correspondence. When the client triggers the switch, the client module promptly conveys the data. In the event that the transport module gets the coordinated flag, it hums and shows the notice in the display to advise the transport driver that somebody is holding up to blind people on the transport. The intelligent remote correspondence help framework is a legitimate and minimal effort gadget for helping outwardly weakened individuals to utilize the city transports.
Automated segmentation of intracranial hemorrhages from 3D CT (2022)

Intracranial hemorrhage segmentation challenge (INSTANCE 2022) offers a platform for researchers to compare their solutions to segmentation of hemorrhage stroke regions from 3D CTs. In this work, we describe our solution to INSTANCE 2022. We use a 2D segmentation network, SegResNet from MONAI, operating slice-wise without resampling. The final submission is an ensemble of 18 models. Our solution (team name NVAUTO) achieves the top place in terms of Dice metric (0.721), and overall rank 2. It is implemented with Auto3DSeg.
The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O2 and CO binding to iron protoporphyrin IX (2009)

Complexation of iron(II) protoporphyrin IX (Fe(2+)PP) into a genetically engineered heme pocket on recombinant human serum albumin (rHSA) creates an artificial hemoprotein which can bind O(2) reversibly at room temperature. Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group. Replacing His-146 and/or Lys-190 with Arg resolved the structured heterogeneity of the possible two complexing modes of the porphyrin and afforded a single O(2) and CO binding affinity. Resonance Raman spectra show only one geometry of the axial His coordination to the central ferrous ion of the Fe(2+)PP.
A Novel Proof for the DoF Region of the MIMO Broadcast Channel with No\n CSIT (2014)

In this paper, a new proof for the degrees of freedom (DoF) region of the\nK-user multiple-input multiple-output (MIMO) broadcast channel (BC) with no\nchannel state information at the transmitter (CSIT) and perfect channel state\ninformation at the receivers (CSIR) is provided. Based on this proof, the\ncapacity region of a certain class of MIMO BC with channel distribution\ninformation at the transmitter (CDIT) and perfect CSIR is derived. Finally, an\nouter bound for the DoF region of the MIMO interference channel (IC) with no\nCSIT is provided.\n
IBM z990 soft error detection and recovery (2005)

Soft errors in logic are becoming more significant in the design of computer systems due to increased sensitivities of latches and combinatorial logic and the increased number of transistors on a chip. At the same time, users of computer systems continue to expect higher levels of system reliability. Therefore, the investment in hardware and firmware software mitigation is likely to continue to rise. The IBM eServer z990 system is designed to detect and recover from myriad instances of soft and permanent errors. The error detection and recovery within the z990 processors and the "nest" chips is described with respect to the system level protection against soft errors.
Radiomics and Radiogenomics (2019)

In the recent past, medicine has not had much choice in treating patients or predicting the course of the disease.Today, modern methods are being developed that will improve the daily life of patients in the form of better diagnostics and therapy.The idea that is based on personalized medicine by collecting data from medical images is called radiomics.Radiomics collects data from radiological images such as computed tomography or magnetic resonance imaging.Features collected from the object of interest are shape, texture, intensity, histogram, margins, etc.These data are subsequently combined with demographic and clinical data to make an analysis.So, radiomics through artificial intelligence, segmentation and other methods may in the future provide the best possible medical care for everyone.The science that links radiological and genetic data is called radiogenomics.Radiogenomics tends to be able to replace some of the pathohistological methods based on imaging data.Thus, the main goals of radiomics and radiogenomics are: Prediction and prognosis of the course of the disease, determining the best therapy and providing less invasive diagnostics.
Study of HfSiOx film as gate insulator for GaN power device (2021)

Gallium nitride (GaN) high-electron-mobility transistor (HEMT) and vertical GaN metal-oxide-semiconductor (MOS) devices have potential application to high power and high frequency because of their superior characteristics, such as wide band gap (B g ), high electron saturation velocity, and a high critical breakdown voltage [ 1 – 3 ]. Gate insulator plays an important role to suppress the leakage current in both GaN HEMT and GaN MOS devices. Various materials such as SiO 2 , Al 2 O 3 , HfO 2 , AlSiO x , and HfSiO x have been widely investigated as gate insulator, and films of these materials are typically deposited via chemical vapor deposition or atomic layer deposition (ALD) [ 4 – 10 ]. Figure 1 shows the relationship between dielectric constant ( k ) and B g of candidate gate insulators [11] . The B g generally decreases as the k value increases. HfO 2 is known to have a high k value but crystallization temperature is as low as 400°C. Al 2 O 3 starts to crystalize around 700°C. On the other hand, silicate materials such as AlSiO x and HfSiO x have a more stable amorphous structure at 800°C and expect to suppress the leakage current. Here, AlSiO x and HfSiO x films were formed by a two-step process such as film formation of (Al 2 O 3 ) m /(SiO 2 ) n and (HfO 2 ) m /(SiO 2 ) n nanolaminate structures using ALD, respectively, and post-deposition annealing (PDA) treatment.
Probe-Based Confocal Laser Endomicroscopy During Transurethral Resection of Bladder Tumors Improves the Diagnostic Accuracy and Therapeutic Efficacy (2019)

Probe-based confocal laser endomicroscopy is a promising method to provide the surgeon during the transurethral resection of a bladder tumor with real-time tumor histology, regardless of the tumor's gross appearance. Furthermore, it also may improve the therapeutic efficacy with longer recurrence-free periods.
High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease (2021)

Canavan disease (CD) is a progressive, fatal neurological disorder that begins in infancy resulting from a mutation in aspartoacyclase (ASPA), an enzyme that catalyzes the deacetylation of <i>N</i>-acetyl aspartate (NAA) into acetate and aspartate. Increased NAA levels in the brains of affected children are one of the hallmarks of CD. Interestingly, genetic deletion of <i>N</i>-acetyltransferase-8-like (NAT8L), which encodes aspartate <i>N</i>-aceyltransferase (ANAT), an enzyme responsible for the synthesis of NAA from l-aspartate and acetyl-CoA, leads to normalization of NAA levels and improvement of symptoms in several genetically engineered mouse models of CD. Therefore, pharmacological inhibition of ANAT presents a promising therapeutic strategy for treating CD. Currently, however, there are no clinically viable ANAT inhibitors. Herein we describe the development of fluorescence-based high throughput screening (HTS) and radioactive-based orthogonal assays using recombinant human ANAT expressed in <i>E. coli</i>. In the fluorescence-based assay, ANAT activity was linear with respect to time of incubation up to 30 min and protein concentration up to 97.5 ng/μL with <i>K</i><sub>m</sub> values for l-aspartate and acetyl-CoA of 237 μM and 11 μM, respectively. Using this optimized assay, we conducted a pilot screening of a 10 000-compound library. Hits from the fluorescence-based assay were subjected to an orthogonal radioactive-based assay using L-[U-<sup>14</sup>C] aspartate as a substrate. Two compounds were confirmed to have dose-dependent inhibition in both assays. Inhibitory kinetics studies of the most potent compound revealed an uncompetitive inhibitory mechanism with respect to l-aspartate and a noncompetitive inhibitory mechanism against acetyl-CoA. The screening cascade developed herein will enable large-scale compound library screening to identify novel ANAT inhibitors as leads for further medicinal chemistry optimization.
Comparative analysis of mycelial growth of pathogenic and nonpathogenic <I>Fusarium oxysporum</I> on plant roots (2003)

In the present study, a green fluorescence protein (GFP) gene was introduced as a monitoring reporter into mycelial protoplasts of different formae speciales of Fusarium oxysporum (lycopersici, melonis and fragariae) to analyze infection behavior of pathogenic and nonpathogenic fungi on roots of host and nonhost plants. Successful integration of the GFP gene into chromosome was confirmed by polymerase chain reaction and Southern hybridization analysis. GFP-marked fungi emitted bright green fluorescence under UV irradiation. Transformed microconidia of F. oxysporum were inoculated by dropping conidial suspension onto roots of tomato and melon cotyledonal seedlings. Fungal development on roots was observed with a fluorescence microscope at the post-inoculation stage (1 to 3 days after inoculation). As a result, the microconidia of all formae speciales germinated and attached to root surface and elongated hyphae to reticulate root surface, irrespective of host and nonhost plants. After this reticular elongation of hyphae, the pathogenic fungi on host plant roots invaded to cause necrosis at the inoculation site of roots. Thus, the present results demonstrated that both pathogenic (F. oxysporum f. sp. lycopersici on tomato) and nonpathogenic fungi (F. oxysporum f. sp. fragariae on tomato and melon, and F. oxysporum f. sp. melonis on tomato) could indistinctively elongate hyphae and colonize host and nonhost plant roots at the early stage of inoculation, and only the pathogenic fungi invade host roots to cause the symptoms after mycelial colonization.
Excited-state torsional dynamics of c i s-stilbene from resonance Raman intensities (1984)

Resonance Raman spectra of cis-stilbene have been obtained using excitation at 356, 299, 282, and 266 nm. Intense Raman lines at 403 and 560 cm−1 are observed in the frequency region characteristic of double bond torsions. Resonance spectra of trans-stilbene show no Raman lines of comparable intensity which can be assigned to double bond torsions. These results suggest that electronically excited cis-stilbene twists about its central double bond much more rapidly than does the trans isomer. To quantitate these observations, the Raman lines of cis-stilbene at 165, 403, 560, and 963 cm−1 are assigned to specific out-of-plane normal modes by comparison with QCFF/PI calculations. We then model the excited state surface as a linear dissociative potential along the 560 cm−1 double bond torsion and a harmonic potential along all other modes. The experimental Raman intensities are used to determine the slope of the excited state torsional potential and the excited state origin displacements in the harmonic modes. Wave packet propagation on this excited state surface gives a 25° torsion about the central double bond of cis-stilbene in only 20 fs. The differences in excited state torsional dynamics between cis- and trans-stilbene are attributed to ground state conformational distortions due to the severe steric hindrance in the cis isomer.
Abstract SY25-01: Functional genomics, transformation, and resistance (2011)

Abstract Recent advances in genomics now make it possible to consider enumerating all of the genetic lesions in specific cancers. While these approaches will yield critical information regarding the identify, number, and types of alterations found in human tumors, a complementary approach to decipher the molecular basis of malignant transformation depends upon the application of genome scale tools to annotate the function of genes involved in cancer initiation and progression. Over the past several years, we have developed genome scale RNAi libraries and open reading frame expression libraries that permit a systematic evaluation of genes involved in cancer initiation and maintenance. Using these libraries, we have now performed screens in a panel of human cancer cell lines to systematically identify cancer vulnerabilities. By combining these functional approaches with information derived from mapping the structural abnormalities present in cancer genomes, we have identified several new oncogenes that contribute to cancer development. In addition, many commonly occurring and well-validated oncogenes and tumor suppressor genes remain refractory to molecularly targeted therapies. An alternative strategy for targeting such cancer drivers is to identify gene products that, when suppressed or inhibited, result in cell death only in the presence of an oncogenic allele. Through the use of systematic RNAi screens, we have identified several genes that act as synthetic lethal partners to known oncogenes. Taken together, these studies suggest that combining forward and reverse genetic approaches with information derived from the cancer genome characterization projects will yield a comprehensive list of cancer vulnerabilities and establish a general approach for the rational identification of oncogenic and co-dependent pathways in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr SY25-01. doi:10.1158/1538-7445.AM2011-SY25-01
Multipotent progenitors from MSCs are regulated by Wnt/beta-catenin signaling (2005)

Tataria, Monika MD; Ailles, Laurie PhD; Jenkins, Donald MD; Longaker, Michael T. Md, MBA; Weissman, Irving MD; Sylvester, Karl MD Author Information
Volumetric texture analysis of breast lesions on contrast‐enhanced magnetic resonance images (2007)

Automated image analysis aims to extract relevant information from contrast-enhanced magnetic resonance images (CE-MRI) of the breast and improve the accuracy and consistency of image interpretation. In this work, we extend the traditional 2D gray-level co-occurrence matrix (GLCM) method to investigate a volumetric texture analysis approach and apply it for the characterization of breast MR lesions. Our database of breast MR images was obtained using a T1-weighted 3D spoiled gradient echo sequence and consists of 121 biopsy-proven lesions (77 malignant and 44 benign). A fuzzy c-means clustering (FCM) based method is employed to automatically segment 3D breast lesions on CE-MR images. For each 3D lesion, a nondirectional GLCM is then computed on the first postcontrast frame by summing 13 directional GLCMs. Texture features are extracted from the nondirectional GLCMs and the performance of each texture feature in the task of distinguishing between malignant and benign breast lesions is assessed by receiver operating characteristics (ROC) analysis. Our results show that the classification performance of volumetric texture features is significantly better than that based on 2D analysis. Our investigations of the effects of various of parameters on the diagnostic accuracy provided means for the optimal use of the approach.
Phenotypical Enrichment Strategies for Microarray DataAnalysis Applied in a Type II Diabetes Study (2005)

Combining results from gene microarrays, clinical chemistry, and quantitative tissue histomorphology in an integrated bioinformatics setting enables prioritization of gene families as well as individual genes in a type II diabetes animal study. This new methodology takes advantage of a time-controlled mouse study as the animals progress from a normal phenotype to that of type II diabetes. Profiles from different levels of the biological hierarchy of unpooled entities provide an encompassing, system-wide view of biological changes. Here, phenotypic changes on the tissue-structural and physiological level are used as statistical covariants to enrich the gene expression analysis, suggesting correlative processes between gene expression and phenotype unlocked by multi-sample comparisons. We apply correlative and gene set enrichment procedures and compare the results to differential analysis to identify molecular markers. Evaluation based on ontological classifications proves changes in prioritization of disease-related genes that would have been overlooked by conventional gene expression analyses strategies.
Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1 (2006)

Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase (PPIase) Pin1 is a negative regulator of Btk, controlling its expression level by reducing its half-life, whereas the catalytic activity of Btk was unaffected. The negative regulatory effect of Pin1 was observed both in cell lines and in Pin(-/-) mice and was found to be dependent on a functionally intact Btk. This may constitute a feedback loop for the regulation of Btk. The target region in Btk was localized to the pleckstrin homology domain suggesting that interphase phosphorylation of serine 115 (Ser-115) in Btk is required, whereas mitosis phosphorylation of serine 21 (Ser-21) is critical. Accordingly, Pin 1 was shown to associate with Btk through binding to Ser-21 and -115, respectively, both of which lie in a classical Pin1-binding pocket. Using a phosphomitotic antibody, it was found that Btk harbors a bona fide MPM2 epitope corresponding to a phosphorylated serine or threonine residue followed by a proline. Our results indicate that the peptidylprolyl isomerase Pin1 interacts with Btk in a cell cycle-dependent manner, regulating the Btk expression level.
Lipid-based carriers for controlled delivery of nitric oxide (2017)

Nitric oxide (NO) is crucial for body homeostasis at moderate levels, but cytotoxic at high levels, thus making it a potential candidate for anticancer therapies and antibacterial surface coatings. To date, NO use has been limited due to its very short half-life. Many strategies have been utilized in an attempt to control the half-life of NO, including (but not limited to) lipid-based carriers, due to their biocompatibility and versatility. Areas covered: In this review, we discuss the latest studies that aimed to control the release of NO via a variety of lipid-based delivery carriers, such as liposomes (echogenic and normal) and microbubbles. In addition, we discuss the different types of NO donors used to control and target the release of NO. Expert opinion: Achieving a NO releasing lipid-based systems to mimic the natural release rate of NO remains a challenging task. Many promising strategies are still to be tackled, such as NO release supported lipid bilayers using GPx mimicking catalysts instead of vesicles, or the use of lipophillic NO donors such as nitrooleate instead of the conventional hydrophilic NO donors. These new strategies may present us with better alternatives to the previously published systems.
Measurement of the inclusive isolated photon production cross section in $$\text{ p }\text{ p }$$ collisions at $$\sqrt{s}=7$$ TeV (2019)

Abstract The production cross section of inclusive isolated photons has been measured by the ALICE experiment at the CERN LHC in pp collisions at a centre-of-momentum energy of $$\sqrt{s}=$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo></mml:mrow></mml:math> 7 TeV. The measurement is performed with the electromagnetic calorimeter EMCal and the central tracking detectors, covering a range of $$|\eta |&lt;0.27$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo>|</mml:mo><mml:mi>η</mml:mi><mml:mo>|</mml:mo><mml:mo>&lt;</mml:mo><mml:mn>0.27</mml:mn></mml:mrow></mml:math> in pseudorapidity and a transverse momentum range of $$ 10&lt; p_\mathrm {T}^{\gamma }&lt; 60~\mathrm {GeV}/c$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>10</mml:mn><mml:mo>&lt;</mml:mo><mml:msubsup><mml:mi>p</mml:mi><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mi>γ</mml:mi></mml:msubsup><mml:mo>&lt;</mml:mo><mml:mn>60</mml:mn><mml:mspace/><mml:mi>GeV</mml:mi><mml:mo>/</mml:mo><mml:mi>c</mml:mi></mml:mrow></mml:math> . The result extends the $$p_\mathrm {T}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>p</mml:mi><mml:mi>T</mml:mi></mml:msub></mml:math> coverage of previously published results of the ATLAS and CMS experiments at the same collision energy to smaller $$p_\mathrm {T}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>p</mml:mi><mml:mi>T</mml:mi></mml:msub></mml:math> . The measurement is compared to next-to-leading order perturbative QCD calculations and to the results from the ATLAS and CMS experiments. All measurements and theory predictions are in agreement with each other.
Design of High Speed Modular Exponentiation Operation Method for RSA Algorithm (2008)

최근 정보통신의 급속한 발달로 온라인 서비스에 기반을 둔 기업들이 많이 구축되고 있다. 이들 기업들은 개인정보를 수집하여 고객관리를하며 유료 서비스의 경우 결제정보를 요청하여 대금을 지불하는 방식을 취한다. 이와 같은 정보의 유통과 관리는 최근 큰 이슈가 되고 있으나 대부분의 기업들이 정보보호에 대한 인식이 부족한 현실이다. 실제로 국내 최대 오픈마켓에서 해킹으로 대량의 고객 개인정보가 노출되기도 했다. 따라서 본 논문에서는 고객관리를 위한 개인정보의 불법공격이나 해킹에 대비하기 위해 가장 보편화된 RSA 암호 알고리즘 부하를 줄이는 방법을 제안한다. 이때 부하를 줄이는 방법은 Binary NAF Method를 이용하여 RSA 핵심 연산인 모듈러 멱승 연산을 고속으로 처리할 수 있도록 설계하였고 기존 Binary Method와 Windows Method를 이용한 모듈러 멱승 알고리즘을 구현하여 비교 평가 하였다. At a recent, enterprises based on online-service are established because of rapid growth of information network. These enterprises collect personal information and do customer management. If customers use a paid service, company send billing information to customer and customer pay it. Such circulation and management of information is big issue but most companies don't care of information security. Actually, personal information that was managed by largest internal open-market was exposed. For safe customer information management, this paper proposes the method that decrease load of RSA cryptography algorithm that is commonly used for preventing from illegal attack or hacking. The method for decreasing load was designed by Binary NAF Method and it can operates modular Exponentiation rapidly. We implemented modular Exponentiation algorithm using existing Binary Method and Windows Method and compared and evaluated it.