gebhart/patrepeval huggingface dataset:
Multi-Mode Rectifier-Based LLC Resonant Converter for Wide Input Voltage Range Applications (2021)

A Photovoltaics system needs to be conditioned by a wide voltage gain converter to achieve high efficiency under a wide voltage range. The LLC resonant converter is a common solution in such applications, owing to its zero-voltage switching and zero-current switching capabilities. However, the frequency modulation in the LLC converter requires operating at a significantly different frequency from the resonant converter to cover the PV’s wide voltage, sacrificing efficiency. In this paper, an LLC resonant converter using a novel rectifier structure is proposed to achieve high efficiency under wide PV voltage. The novel rectifier structure can operate in three modes of operation— voltage-tripler rectifier, voltage-quadrupler rectifier, and voltage fifthfolder rectifier. In addition to the LLC converter’s soft-switching capability, this rectifier can narrow the switching frequency range and provide high voltage gain with a moderate transformer size. Finally, a 250-W experimental prototype with a high output voltage of 500 V was built and validated the proposed converter’s effectiveness.
Interpretation of Dimensionally-reduced Crime Data: A Study with Untrained Domain Experts (2017)

Dimensionality reduction (DR) techniques aim to reduce the amount of considered dimensions, yet preserving as much information as possible. According to many visualization researchers, DR results lack interpretability, in particular for domain experts not familiar with machine learning or advanced statistics. Thus, interactive visual methods have been extensively researched for their ability to improve transparency and ease the interpretation of results. However, these methods have primarily been evaluated using case studies and interviews with experts trained in DR. In this paper, we describe a phenomenological analysis investigating if researchers with no or only limited training in machine learning or advanced statistics can interpret the depiction of a data projection and what their incentives are during interaction. We, therefore, developed an interactive system for DR, which unifies mixed data types as they appear in real-world data. Based on this system, we provided data analys ts of a Law Enforcement Agency (LEA) with dimensionally-reduced crime data and let them explore and analyze domain-relevant tasks without providing further conceptual information. Results of our study reveal that these untrained experts encounter few difficulties in interpreting the results and drawing conclusions given a domain relevant use case and their experience. We further discuss the results based on collected informal feedback and observations.
WindCam and MSPI: two cloud and aerosol instrument concepts derived from Terra/MISR heritage (2008)

The Multi-angle Imaging SpectroRadiometer (MISR) has been acquiring global cloud and aerosol data from polar orbit since February 2000. MISR acquires moderately high-resolution imagery at nine view angles from nadir to 70.5&deg;, in four visible/near-infrared spectral bands. Stereoscopic parallax, time lapse among the nine views, and the variation of radiance with angle and wavelength enable retrieval of geometric cloud and aerosol plume heights, height-resolved cloud-tracked winds, and aerosol optical depth and particle property information. Two instrument concepts based upon MISR heritage are in development. The Cloud Motion Vector Camera, or WindCam, is a simplified version comprised of a lightweight, compact, wide-angle camera to acquire multiangle stereo imagery at a single visible wavelength. A constellation of three WindCam instruments in polar Earth orbit would obtain height-resolved cloud-motion winds with daily global coverage, making it a low-cost complement to a spaceborne lidar wind measurement system. The Multiangle SpectroPolarimetric Imager (MSPI) is aimed at aerosol and cloud microphysical properties, and is a candidate for the National Research Council Decadal Survey's Aerosol-Cloud-Ecosystem (ACE) mission. MSPI combines the capabilities of MISR with those of other aerosol sensors, extending the spectral coverage to the ultraviolet and shortwave infrared and incorporating high-accuracy polarimetric imaging. Based on requirements for the nonimaging Aerosol Polarimeter Sensor on NASA's Glory mission, a degree of linear polarization uncertainty of 0.5% is specified within a subset of the MSPI bands. We are developing a polarization imaging approach using photoelastic modulators (PEMs) to accomplish this objective.
Morphology and structure of a one-dimensional graphite polymer, poly-peri-naphthalene (1986)

Very fine fibers of 3,4,9,10-perylenetetracarboxylicdianhydride heated above 520 °C in argon (Ar) or argon/hydrogen (Ar/H2) gas were grown on pressed pellets. The fibers synthesized in Ar had a rectangular cross section of about 0.1–0.4 μm on a side with lengths up to 10 mm. By contrast, the fibers synthesized in Ar/H2 had a flat-ribbon like morphology with dimensions of 0.1–0.2 μm on one side and 0.4–2.0 μm on the side. Transmission electron microscopy revealed that component molecules roughly stacked parallel to the fiber axis. Infrared spectra of the fibers synthesized at around 520–550 °C exhibited aromatic C–H and C■C absorptions. The IR and laser–Raman spectra of the fibers can reasonably be explained by theoretically estimated vibrational modes of a poly-peri-naphthalene (PPN) structure. From these results together with elemental analysis data, we conclude that the fibers essentially consist of PPN molecules.
Attitudes and Usage of the Food and Drug Administration Adverse Event Reporting System Among Gastroenterology Nurse Practitioners and Physician Assistants (2016)

The Food and Drug Administration Adverse Event Reporting System (FAERS) is used for postmarketing pharmacovigilance. Our study sought to assess attitudes and usage of the FAERS among gastroenterology nurse practitioners (NPs) and physician assistants (PAs). A survey was administered at the August 2012 Principles of Gastroenterology for the Nurse Practitioner and Physician Assistant course, held in Chicago, IL. Of the 128 respondents, 123 (96%) reported a specialty in gastroenterology or hepatology and were included in analysis. Eighty-nine participants were NPs and 32 PAs, whereas 2 did not report their profession. Although 119 (98%) agreed or strongly agreed with the statement that accurately reporting adverse drug reactions is an important process to optimize patient safety, the majority of participants (54% NPs and 81% PAs) were unfamiliar with the FAERS. In addition, only 20% of NPs and 9% of PAs reported learning about the FAERS in NP or PA schooling. Our study shows enthusiasm among gastroenterology NPs and PAs for the reporting of adverse drug reactions, coupled with a lack of familiarity with the FAERS. This presents an opportunity for enhanced education about reporting of adverse drug reactions for gastroenterology NPs and PAs.
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder (2018)

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (<i>n</i> ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
Controlling polyelectrolyte equilibria and structure via counterion-solvent interactions (2009)

International audience
A Stochastic Model For A New Robust Nlms Algorithm (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
Isolation of Bioactive Compounds from Calicotome villosa Stems (2018)

A phenylethanoid, two steroids, a flavone glucoside and a chalcone have been isolated for the first time from the stems of <i>Calicotome villosa</i> together with a previously isolated flavone glucoside. Their structures were determined by spectroscopic analyses (NMR, HRMS) as basalethanoïd B (<b>1</b>), β-sitosterol and stigmasterol (<b>2</b>), chrysine-7-<i>O</i>-β-d-glucopyranoside (<b>3</b>), chrysine 7-((6''-<i>O</i>-acetyl)-<i>O</i>-β-d-glucopyranoside) (<b>4</b>) and calythropsin (<b>5</b>). The crude extracts and the isolated compounds (except 4), were evaluated for their antioxidant, antimicrobial (against two Gram-positive bacterial strains: <i>Staphylococcus aureus</i>, <i>Bacillus cereus</i>, four Gram-negative bacterial strains: <i>Staphylococcus epidermidis</i>, <i>Klebsiella pneumonia</i>, <i>Acinetobacter baumanii</i>, and three yeasts: <i>Candida albicans</i>, <i>Candida tropicalis</i>, and <i>Candida glabrata</i>), hemolytic, antidiabetic, anti-inflammatory and cytotoxic activity. The crude extracts showed good ability to scavenge the free radical DPPH. Methanol stem extract followed by the dichloromethane stem extract showed moderate antimicrobial potency; furthermore, at 1 mg/mL the methanol extract showed an inhibition of <i>C. albicans</i> growth comparable to nystatin. Dichloromethane, methanol, and aqueous extracts inhibited 98%, 90%, and 80% of HeLa cell proliferation at 2 mg/mL respectively. Weak hypoglycemic and hemolytic effects were exhibited by the crude extracts. Among all the tested compounds, compound <b>3</b> showed remarkable hypoglycemic potential (93% at 0.1 mg/mL) followed by compound <b>5</b> (90% at 0.3 mg/mL). Compound <b>5</b> was the most effective in the DPPH<b><sup>.</sup></b> scavenging assay (100% at 0.1 mg/mL) and cytotoxic assay on HeLa cells (99% and 90% after 24 and 48 h of treatment at 0.1 mg/mL, respectively). No anti-inflammatory effects were displayed by any of the crude extracts or the isolated compounds at any of the tested concentrations.
Molecular and Cellular Control of T1/T2 Immunity at the Interface between Antimicrobial Defense and Immune Pathology (2004)

The immune system evolved to rapidly recognize infectious threats and promptly mobilize cellular effectors to the infection site. Establishment of a robust T1-type immunity is a prerequisite for effective defense against most viruses and intracellular bacteria. However, accumulating evidence shows that T1 and T2 responses during such infections are not mutually exclusive. A possibility may be that the dual T1-T2 nature of antiviral immune responses is merely a byproduct of less than perfect crossregulatory mechanisms. Herein, we discuss molecular and cellular mechanisms of T-cell differentiation along with recent evidence supporting the hypothesis that rather than representing an epiphenomenon, coinduction of virus-specific T2 cells plays a significant homeostatic role. Thus, molecular pathways that regulate IL-4 production during influenza virus infection monitor T1-mediated immune responses in vital organs such as lungs and prevent immune pathology that may otherwise interfere with recovery from disease. Such evidence suggests that coinduction of T2 immunity maintains immune homeostasis during T1-mediated defense reactions. Finally, we outline implications on the earlier concept of T1/T2 dichotomy, supporting a model in which these two subsets, rather than being mutually antagonistic, together facilitate the recovery from infection.
Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45 (2015)

Leptospirosis is a bacterial zoonotic disease caused by an infection with a spirochete belonging to the genus Leptospira. In animals, leptospirosis displays a wide range of pathologies, including fever, abortion, icterus, and uveitis. Conversely, infection in humans is associated with multi-organ injury, resulting in an increased rate of fatalities. Pathogenic leptospires are able to translocate through cell monolayers at a rate significantly greater than that of non-pathogenic leptospires. Thus, vaccine approaches have been focused on targeting bacterial motility, lipopolysaccharides (LPSs), lipoproteins, outer-membrane proteins (OMPs) and other potential virulence factors. Previous studies have indicated that leptospiral proteins elicit long-lasting immunological memory in infected humans. In the study reported here, the efficacy of a synthetic consensus DNA vaccine developed against the Leptospira membrane lipoprotein LipL45 was tested. After in vivo electroporation (EP) mediated intramuscular immunization with a synthetic LipL45 DNA vaccine (pLipL45) immunized mice developed a significant cellular response along with the development of anti-LipL45-specific antibodies. Specifically, the pLipL45 vaccine induced a significant Th1 type immune response, indicated by the higher production of IL-12 and IFN-γ cytokines. The results presented here are the first demonstration that a LipL45 based DNA immunogen has potential as a anti-Leptospira vaccine.
High Bit-Depth Medical Image Compression With HEVC (2017)

Efficient storing and retrieval of medical images has direct impact on reducing costs and improving access in cloud-based health care services. JPEG 2000 is currently the commonly used compression format for medical images shared using the DICOM standard. However, new formats such as high efficiency video coding (HEVC) can provide better compression efficiency compared to JPEG 2000. Furthermore, JPEG 2000 is not suitable for efficiently storing image series and 3-D imagery. Using HEVC, a single format can support all forms of medical images. This paper presents the use of HEVC for diagnostically acceptable medical image compression, focusing on compression efficiency compared to JPEG 2000. Diagnostically acceptable lossy compression and complexity of high bit-depth medical image compression are studied. Based on an established medically acceptable compression range for JPEG 2000, this paper establishes acceptable HEVC compression range for medical imaging applications. Experimental results show that using HEVC can increase the compression performance, compared to JPEG 2000, by over 54%. Along with this, a new method for reducing computational complexity of HEVC encoding for medical images is proposed. Results show that HEVC intra encoding complexity can be reduced by over 55% with negligible increase in file size.
Modifications of the expression of liver‐specific and non‐specific messenger RNAs during azo‐dye hepatocarcinogenesis (1985)

The expression of specific and non-specific rat liver messenger RNAs has been studied during 3'-methyl-4-(dimethylamino)azobenzene (3'-MeDAB) carcinogenesis, using cDNA probes complementary to mRNAs encoding aldolase A and B, L-type pyruvate kinase, albumin, alpha-fetoprotein, transferrin and an unidentified 2.7 X 10(3)-base mRNA. mRNAs specific for undifferentiated cells, such as those encoding aldolase A and the unidentified 2.7 X 10(3)-base species were re-expressed very early, being easily detectable at the 1st week of 3'-MeDAB treatment. They reached a maximum of expression at the 4th week. Simultaneously the levels of aldolase B and L-type pyruvate kinase mRNAs dramatically decreased as compared to controls, but remained responsive to induction by a high-carbohydrate diet. Albumin and transferrin mRNA levels were only slightly modified in the course of the carcinogenic diet. At the terminal stage of hepatocarcinogenesis, i.e. in malignant hepatoma cells, expression and inducibility of aldolase B and L-type pyruvate kinase mRNAs were similar to those in normal adult rats while mRNAs specific for undifferentiated or foetal stages were also synthesized. The very early changes in gene expression for aldolases A and B, L-type pyruvate kinase and the 2.7 X 10(3)-base mRNA species could indicate that carcinogenic diet modifies gene control mechanisms long before inducing hepatoma.
SYST-07 WINDOW-OF-OPPORTUNITY STUDY OF ONC201 IN PEDIATRIC PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND THALAMIC GLIOMA (2022)

Abstract BACKGROUND H3 K27M-mutant diffuse midline glioma is a universally fatal malignancy primarily affecting children and young adults; no effective systemic therapy is available. ONC201, a first-in-class imipridone, is an oral, blood-brain barrier penetrating, selective small molecule antagonist of dopamine receptor D2/3 and agonist of the mitochondrial protease ClpP. ONC201 monotherapy demonstrated durable objective responses in adults with recurrent H3 K27M-mutant glioma. This phase 1 trial will evaluate ONC201±radiotherapy (RT) in pediatric patients with H3 K27M-mutant midline glioma DIPG. METHODS This multicenter, open-label, dose escalation and expansion phase 1 study of ONC201 is comprised of eight arms that will evaluate the recommended phase 2 dose (RP2D) of ONC201, biomarkers, and pharmacokinetics (PK) of ONC201±RT in various treatment settings (NCT03416530). Arm G previously defined the RP2D for twice-weekly ONC201 on consecutive days. Arm H, for which enrollment is ongoing, will estimate the influence of tumor location and blood-brain barrier integrity on PK and intratumoral ONC201 exposure in biopsy-eligible pediatric tumors (DIPG or contrast-enhancing thalamic glioma). Patients eligible for Arm H will be aged 2-≤19 years, ≥2 weeks from last RT administration, and have a KPS/LPS ≥50; prior confirmation of H3 K27M mutation is not required. In Arm H, single-agent ONC201 administration will occur twice-weekly on consecutive days during each 21-day cycle at the RP2D defined in Arm G. Arm H has a planned enrollment of 27 patients (DIPG, n=15; thalamic glioma, n=12), with three patients undergoing a single biopsy at each of the following time points: 1-3 h post-first dose, 22-26 h post-second dose, 1-3 h post-first dose, 6-10 h post-second dose, and 22-26 h post-second dose. The 22-26 h post-first dose biopsy in thalamic glioma was previously collected and will not be assessed in this treatment arm. Plasma for PK analysis will be collected from all patients.
Self–Organizing Neural Networks: Parallels Between “Big Imaging” and Sparse Imaging in Electron Microscopy (2016)

Journal Article Self–Organizing Neural Networks: Parallels Between "Big Imaging" and Sparse Imaging in Electron Microscopy Get access Karl Hujsak, Karl Hujsak Department of Materials Science & Engineering, Northwestern University, Evanston, Illinois, USA Search for other works by this author on: Oxford Academic Google Scholar Vinayak P Dravid Vinayak P Dravid Department of Materials Science & Engineering, Northwestern University, Evanston, Illinois, USADirector, NUANCE Center, Northwestern University, Evanston, Illinois, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 534–535, https://doi.org/10.1017/S1431927616003524 Published: 25 July 2016
A frequency/time domain characterization technique for frequency-translating devices (2002)

A novel approach and a new measurement setup for the characterization of frequency translating devices (FTD) are proposed. The proposed approach allows for an automated, one-step full characterization of FTDs by measuring both the magnitudes and phases of the incident and reflected waves at all signal ports. The application of the proposed approach and the developed measurement setup to the characterization of a double balanced mixer is presented.
Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography/Time-of-Flight Mass Spectrometry (1994)

We report the application of aerosol matrix-assisted laser desorption ionization (MALDI) to liquid chromatography/ mass spectrometry (LC/MS). The aerosol MALDI experiment uses aerosol liquid introduction in conjunction with pulsed UV laser ionization to form ions from large biomolecules in solution. Mass analysis is achieved in a time-of-flight mass spectrometer. In the LC/MALDI-MS experiment, the matrix solution is combined with the column effluent in a mixing tee. LC/MALDI-MS is demonstrated for the separation of brady kinin, gramicidin S, and myoglobin. © 1994, American Chemical Society. All rights reserved.
First comprehensive view on a magnetic separation based protein purification processes: From process development to cleaning validation of a GMP‐ready magnetic separator (2019)

Magnetic separation processes are known as integrated bioanalytical protein purification method since decades and are well described. However, use of magnetic separation processes in a regulated industrial production environment has been prevented by the lack of suitable process equipment and prejudice against the productivity of the process and its qualification for cleaning-in-place operation. With the aim of overcoming this prejudice, a comprehensive process development approach is presented, based on a GMP-compliant magnetic separator, including an optimization of the batch adsorption process, implementation into a technical-scale, and the development and validation of cleaning routines for the device. By the implementation of a two-step counter-current binding process, it was possible to raise the yields of the magnetic separation process even for very low concentrated targets in a vast surplus of competing proteins, like the hormone equine chorionic gonadotropin in serum, from 74% to over 95%. For the validation of the cleaning process, a direct surface swabbing method combined with a total organic carbon analysis was established for the determination of two model contaminants. The cleanability of the process equipment was proven for both model contaminants by reliably meeting the 10 ppm criteria.
Effect of PEF and HVED on polyphenol extraction from pomegranate peels (2020)

The aim of this study was to optimize the pulses number of the pulsed electric fields (PEF) and the discharges amount of the high voltage electrical discharges (HVED) treatments for the intensification of polyphenols extraction from pomegranate peels. The latter is a byproduct highly produced in the MENA region. Diffusion using PEF and HVED was therefore carried out for different numbers of pulses and discharges, respectively. Although the extraction yields were higher with HVED treatment, both treatments enhanced the extraction kinetics of polyphenols along with their antiradical activities.