gebhart/patrepeval huggingface dataset:
A Cyber-Resilience Enhancement Method for Network Controlled Microgrid against Denial of Service Attack (2020)

This paper proposes a cyber-resilience enhancement method to detect and mitigate the denial of service (DoS) attacks in microgrids. It interprets the interactions between cyber and physical systems of microgrids by side-channel detector and dynamic priority scheduling at the first time. It is a cross-layer design scalable to realistic controller and device constrains and compatible with existing designs in both cyber and physical systems. At the same time, it can also guarantee the survival by moving target defense even against the infinite-energy DoS attack at the cost of tolerant performance loss. Numerical simulations verify the effectiveness of the proposed method.
Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery (2015)

A new class of thermoresponsive random polyurethanes is successfully synthesized and characterized. Poly(ethylene glycol) diol (Mn = 1500 Da) and 2,2-dimethylolpropionic acid are reacted with isophorone diisocyanate in the presence of methane sulfonic acid catalyst. It is found that these polyurethanes are thermoresponsive in aqueous media and manifest a lower critical solution temperature (LCST) that can be easily tuned from 30 °C to 70 °C by increasing the poly(ethylene glycol) content. Their sharp LCST transitions make these random polyurethanes ideal candidates for stimuli-responsive drug delivery applications. To that end, the ability of these systems to efficiently sequester doxorubicin (up to 36 wt%) by means of a sonication/dialysis method is successfully demonstrated. Additionally, it is also demonstrated that accelerated doxorubicin release kinetics from the nanoparticles can be attained above the LCST.
Functional Outcomes After Syndesmotic Screw Fixation and Removal (2009)

Locked screw and plate removal improved function both subjectively and objectively. Transsyndesmotic implant removal seems to assist improvements in the speed of rehabilitation.
A generalized least-squares minimization method for near infrared diffuse optical tomography. (2007)

Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber optic bundles, and the diffusely transmitted light is collected from the tissue surface. To get functional images of the breast, one needs to use advanced model-based reconstruction methods with these measurements. Accurate modeling of the scatter-dominated transport process leads to a non-linear transport model, which is difficult to solve. A thorough understanding of existing methods and the development of improved novel computational approaches are vital in the process of making diffuse optical imaging a viable clinical tool.
The critical computational parameters were analyzed, such as the finite element mesh resolution and number of boundary measurement points, for their effect upon the reconstructed image quality. The results indicated that increasing number of measurements tends to make the sensitivity of the domain more uniform and reduces the hypersensitivity near the boundary.
A simple framework to incorporate structural priors into the optical image reconstruction procedure is presented through the use of simple weight matrices. This approach can be used in hybrid-optical imaging (e.g. MRI-coupled with NIR), and was proven to be less sensitive to slight imperfections, commonly caused by segmentation or tissue identification or mesh resolution issues, in the given spatial-prior information.
In this thesis, an improved optical image reconstruction method is developed, which takes into account the possible errors associated with the collection of data. This formalized frame-work uses the generalized least-squares (GLS) approach, where the aim is to match the experimental data with the modeled data, using a least-squares minimization, with inclusion of a regularization term to stabilize this ill-posed problem.
This thesis also developed a computationally efficient approach to dramatically reduce the size of the matrix to be inverted in cases where the number of imaging parameters are much larger than the boundary data available. This algorithm reformulates the inversion approach, within most least-squares approaches, to allow the inversion to be based upon the size of the data, rather than the number of imaging field parameters, and this is useful for most three-dimensional (3D) imaging situations.
Prior spatial and spectral information about the tissue is used to improve the spatial resolution and stability of the reconstruction procedure. This GLS approach was able to give reasonable estimates of spectrally-derived tissue functional properties even in cases of highly noisy experimental phantom data.
ChemInform Abstract: Converting Cycloalkanones into N‐Heterocycles: Formal Synthesis of (‐)‐Gephyrotoxin 287C. (2014)

Abstract Key step in the synthesis of Kishi′s intermediate (VIII) on the way to the natural alkaloid gephyrotoxin 287C (IX) is the combination of Beckmann ring expansion and photochemical ring contraction to convert cyclopentanone (I) into pyrrolidine (VI) stereospecifically.
Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients (2004)

Epigenetic gene silencing through DNA methylation is one of the important steps in the mechanism underlying tumorigenesis, including in the stomach. Past lifestyle factors of cancer patients, such as intake of vegetables, are very important in affecting gastric carcinogenesis. However, the relationship between DNA methylation and past dietary habits in cancer patients remains largely unknown. The CDX2 homeobox transcription factor plays a key role in intestinal development, but CDX2 is also expressed in most of the intestinal metaplasia and part of the carcinomas of the stomach. We analyzed the methylation status of the CDX2 5' CpG island in gastric cancer cell lines by methylation-specific PCR (MSP), and then CDX2 mRNA was found to be activated after 5-aza-2'-deoxycytidine treatment of the methylation-positive cells. We further examined the methylation status of CDX2 in primary gastric carcinomas by MSP and compared it with the past lifestyle of the patients, including dietary habits. Methylation of CDX2 was found in 20 (34.5%) of the 58 male patients and one (6.7%) of the 15 female patients. Since the methylation frequency was low in the female patients, the analysis was performed only on the male cases. CDX2 methylation was correlated with the decreased intake of green tea and cruciferous vegetables, and also with full or overeating habits. These findings are consistent with epidemiological observations on gastric cancer. We also analyzed the methylation status of p16/INK4a and hMLH1, but their frequencies were not associated with dietary factors or other lifestyle factors. Thus, diet could be an important factor determining the methylation status of genes such as CDX2 and the resultant aberrant expression of genes involved in carcinogenesis.
Session 2 overview: Processors: Digital architectures and systems subcommittee (2018)

Continued growth in cloud-to-edge applications is driving innovations in digital processors. The first two papers of this session cover next-generation server-class processors. This is followed by an energy-efficient 14nm graphics processor. An SoC configurable with 1–4 chips on an MCM to service multiple markets is described next. The last three papers demonstrate the first implementation of the datagram transport layer security (DTLS) protocol in hardware, an MSP430-compatible microcontroller with dual-mode enabling minimum-power and minimum-energy, and a net-zero-energy (NZE) smart mote SiP for IoT applications.
Path to high energy, high repetition rate tunable femtosecond ultraviolet pulse generation (2021)

We show that a combination of OPCPA and cascaded SFM can efficiently generate 100 µJ, MHz repetition rate, 50 fs, tunable pulses from 279 nm to 317 nm for seeding superconducting X-ray free electron lasers.
An Engineered Monovalent Anti–TNF-α Antibody with pH-Sensitive Binding Abrogates Immunogenicity in Mice following a Single Intravenous Dose (2022)

Therapeutic Abs directed toward TNF-α display significant immunogenicity in humans, frequently leading to lower serum concentrations of the Ab that are associated with lower treatment efficacy. The enhanced incidence of immunogenicity observed with this class of therapeutics may be mediated by the expression of TNF-α as a homotrimer, both as a soluble serum protein and as a membrane-associated protein (mTNF-α) on the surface of dendritic cells. The TNF-α homotrimer enables the formation of polyvalent Ab-TNF-α immune complexes (ICs) that enhance binding to FcR and neonatal FcR. Polyvalent ICs and Ab bound to mTNF-α on the surface of dendritic cells can internalize, traffic to the lysosomes, and be processed for presentation by MHC molecules. To diminish immunogenicity caused by trafficking of ICs and mTNF-α to the lysosomes, we engineered a monovalent format of adalimumab with pH-sensitive binding to TNF-α. The engineered variant, termed AF-M2637, did not cross-link TNF-α trimers and consequently formed small, nonprecipitating ICs only. AF-M2637 bound TNF-α with high affinity at pH 7.4 (EC<sub>50</sub> = 1.1 nM) and displayed a significantly faster dissociation rate than adalimumab at pH 6.0. No immune response to AF-M2637 was detected in mice following a single i.v. dose. In contrast, rapid immunization was detected following the injection of a single i.v. dose of adalimumab, monovalent adalimumab, or the bivalent form of the pH-sensitive variant. These data suggest that ICs and mTNF-α both contribute to the immunogenicity of adalimumab in mice and provide a general strategy for engineering less immunogenic therapeutic TNF-α Abs.
ChemInform Abstract: Revision of the Absolute Configuration of Salicylihalamide A Through Asymmetric Total Synthesis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Observation of Diastereomers of the Hydrogen-Bonded Aggregate Hub(M)3·3CA Using 1H Nuclear Magnetic Resonance Spectroscopy When CA Is an Optically-Active Isocyanuric Acid (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTObservation of Diastereomers of the Hydrogen-Bonded Aggregate Hub(M)3·3CA Using 1H Nuclear Magnetic Resonance Spectroscopy When CA Is an Optically-Active Isocyanuric AcidEric E. Simanek, Shuang Qiao, Insung S. Choi, and George M. WhitesidesView Author Information Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Cite this: J. Org. Chem. 1997, 62, 8, 2619–2621Publication Date (Web):April 18, 1997Publication History Received8 August 1996Published online18 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/jo9615460https://doi.org/10.1021/jo9615460brief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views241Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Melamine,Molecular structure,Molecules,Nuclear magnetic resonance spectroscopy,Solvents Get e-Alerts
A Set of Genes Encoding a Second Toluene Efflux System in Pseudomonas putida DOT-T1E Is Linked to the tod Genes for Toluene Metabolism (2000)

Sequence analysis in Pseudomonas putida DOT-T1E revealed a second toluene efflux system for toluene metabolism encoded by the ttgDEF genes, which are adjacent to the tod genes. The ttgDEF genes were expressed in response to the presence of aromatic hydrocarbons such as toluene and styrene in the culture medium. To characterize the contribution of the TtgDEF system to toluene tolerance in P. putida, site-directed mutagenesis was used to knock out the gene in the wild-type DOT-T1E strain and in a mutant derivative, DOT-T1E-18. This mutant carried a Tn5 insertion in the ttgABC gene cluster, which encodes a toluene efflux pump that is synthesized constitutively. For site-directed mutagenesis, a cassette to knock out the ttgD gene and encoding resistance to tellurite was constructed in vitro and transferred to the corresponding host chromosome via the suicide plasmid pKNG101. Successful replacement of the wild-type sequences with the mutant cassette was confirmed by Southern hybridization. A single ttgD mutant, DOT-T1E-1, and a double mutant with knock outs in the ttgD and ttgA genes, DOT-T1E-82, were obtained and characterized for toluene tolerance. This was assayed by the sudden addition of toluene (0.3% [vol/vol]) to the liquid culture medium of cells growing on Luria-Bertani (LB) medium (noninduced) or on LB medium with toluene supplied via the gas phase (induced). Induced cells of the single ttgD mutant were more sensitive to sudden toluene shock than were the wild-type cells; however, noninduced wild-type and ttgD mutant cells were equally tolerant to toluene shock. Noninduced cells of the double DOT-T1E-82 mutant did not survive upon sudden toluene shock; however, they still remained viable upon sudden toluene shock if they had been previously induced. These results are discussed in the context of the use of multiple efflux pumps involved in solvent tolerance in P. putida DOT-T1E.
Additions and Corrections - Intramolecular Alkoxypalladation/ Carbonylation of Alkenes. (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Intramolecular Alkoxypalladation/ Carbonylation of Alkenes.M. Semmelhack and Christina BodurowCite this: J. Am. Chem. Soc. 1984, 106, 18, 5388Publication Date (Print):September 1, 1984Publication History Published online9 April 2004Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ja00330a606https://doi.org/10.1021/ja00330a606research-articleACS PublicationsRequest reuse permissionsArticle Views49Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cerium oxide as a catalyst for the ketonization of aldehydes: mechanistic insights and a convenient way to alkanes without the consumption of external hydrogen (2017)

The atom-efficient transformation of two aldehyde molecules into a linear alkane at the expense of one carbon dioxide molecule.
Postgrowth Irradiation of Hydrogenated Amorphous Carbon thin Films by Low-Energy Ion Beam (2004)

Liquid crystal (LC) alignment property was investigated on hydrogenated amorphous carbon (a-C:H) thin films. a-C:H thin films were deposited by a remote plasma-enhanced chemical vapor deposition (RPECVD) method with C 2 H 2 and He gases. The surface property of a-C:H thin films was controlled by low-energy Ar ion beams. Ion beam irradiation results in the decrease in optical band gap and transmittance, and the increase in the I D / I G ratio of a-C:H thin films. LC alignment was generated by ion beam irradiation on the surface of a-C:H thin films. LC alignment property was affected by ion-beam-induced anisotropic sp 2 structures on the surface of a-C:H thin films.
A MORE COMPREHENSIVE NDE: PCRT FOR CERAMIC COMPONENTS (2011)

Process Compensated Resonant Testing (PCRT) has been demonstrated as an excellent alternative for ceramic parts, going beyond traditional resonance testing by applying pattern recognition algorithms and process control statistics to precise resonant data. PCRT is used for studying structural integrity and functional performance in a variety of ceramic parts. PCRT is a whole body inspection that detects internal defects such as cracks, voids, and inclusions. PCRT can also perform surface inspection of balls, using Surface Acoustical Waves. PCRT can be performed in real manufacturing time, and computer control eliminates operator error and subjectivity.
Synthesis, properties, and the ring-ring transformation reactions of cyclic siloxanes incorporating skeletal boron atoms: x-ray crystal structures of the strained boracyclotrisiloxane (PhBO)(Ph2SiO)2 and the boracyclotetrasiloxane (PhBO)(Ph2SiO)3 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, properties, and the ring-ring transformation reactions of cyclic siloxanes incorporating skeletal boron atoms: x-ray crystal structures of the strained boracyclotrisiloxane (PhBO)(Ph2SiO)2 and the boracyclotetrasiloxane (PhBO)(Ph2SiO)3Daniel A. Foucher, Alan J. Lough, and Ian MannersCite this: Inorg. Chem. 1992, 31, 14, 3034–3043Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ic00040a010https://doi.org/10.1021/ic00040a010research-articleACS PublicationsRequest reuse permissionsArticle Views386Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A fundamental property for traffic management in ATM networks (2002)

It is desirable that the traffic control policy at a network node depend on the external traffic loads on the input and output links, but not on the detailed addressing or distribution of packets from inputs to outputs. It should be possible to guarantee the grade of service of an input-output connection by controlling the aggregate loads on the input and output. Switch nodes in which such a traffic control policy is possible are said to have the property of the sufficiency of the knowledge of external loads (SKEL). The authors clarify issues related to SKEL and establish its feasibility for a generic switch node on a rigorous basis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Predicting dewatering equipment performance from laboratory tests (1992)

This study was undertaken to evaluate the dewatering characteristics of a bench-scale belt filter press and a full-scale screw press, and to develop a suitable bench-scale test to simulate dewatering in a full-scale screw press. Tests were conducted to determine the effect of pressure and shear on dewatering of anaerobically digested, alum, waste activated, and pulp and paper sludges. The first part of the study involved tests conducted on a bench-scale belt filter press. Pressure was varied to develop performance characteristics with respect to cake and filtrate solids, and polymer demand. The second part of the study consisted of mixing intensity tests conducted to evaluate the effect of shear on dewatering in sludges. The third part of the study involved field evaluation of dewatering performance using a full-scale screw press. Tests were conducted to determine the shear produced in the dewatering process and to assess its effect on polymer conditioning requirements. The tests indicated that the polymer demand produced by the belt filter press simulator and the screw device was minimal. Rather, a substantial polymer demand was observed as a result of shear in the pipes and pumps during full-scale screw press dewatering operations. A combination of a high speed mixing device and a free drainage tester was capable of predicting polymer conditioning requirements for a full-scale screw press. Individual sludge performance characteristics varied with pressure producing changes in cake solids and filtrate quality.
A 6-bit 2GS/s CMOS time-interleaved ADC for analysis of mixed-signal calibration techniques (2014)

A 6-bit 2-GS/s time interleaved (TI) successive approximation register (SAR) analog-to-digital converter (ADC) is designed and fabricated in a 0.13 μm CMOS process. The architecture uses 8 time-interleaved track-and-hold amplifiers (THA), and 16 SAR ADC's. The chip includes (i) a programmable delay cell array to adjust the interleaved sampling phase, and (ii) a 12 Gbps low voltage differential signaling (LVDS) interface. These blocks make the fabricated ADC an excellent platform to evaluate mixed-signal calibration techniques, which are of great interest for application in high-speed optical systems. Measurements of the fabricated ADC show 33.9 dB of peak signal-to-noise-and-distortion ratio (SNDR) and 192 mW of power consumption at 1.2 V.
ChemInform Abstract: Ionic Liquids — New “Solutions” for Transition Metal Catalysis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.