gebhart/patrepeval huggingface dataset:
Microcionamides A and B, Bioactive Peptides from the Philippine Sponge Clathria (Thalysias) abietina (2004)

Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra.
Inverse Faraday effect from the orbital angular momentum of light (2022)

It is usually admitted that the inverse Faraday effect (IFE) originates from the spin angular momentum (SAM) of light. In this paper, we show that part of the IFE in a metal is induced by the orbital angular momentum (OAM) of light. On the basis of a hydrodynamic model of the conduction electron gas, we describe the dependence of the IFE on the spin and orbital angular momenta as well as spin-orbit interaction in a nonparaxial light beam. We also numerically quantify the relative contributions of the SAM and OAM of light to the IFE in a thin gold film illuminated by different focused beams carrying SAM and/or OAM. The OAM of light provides an additional degree of freedom in the control of the IFE and resulting optomagnetic field, thus potentially impacting various research fields, including all-optical magnetization switching and spin-wave excitation.
Development and validation of echocardiography-based machine-learning models to predict mortality (2023)

Funding for Alberta HEART was provided by an Alberta Innovates - Health Solutions Interdisciplinary Team Grant no. AHFMRITG 200801018. P.K. holds a Canadian Institutes of Health Research (CIHR) Sex and Gender Science Chair and a Heart & Stroke Foundation Chair in Cardiovascular Research. A.V. and V.S. received funding from the Mitacs Globalink Research Internship.
Foldamer (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Selective removal of cholesterol by plasmapheresis and the progression of atherosclerosis (1992)

There is a strong correlation of plasma cholesterol levels with the risk of coronary heart diseases as shown by epidemiologic studies. This study was undertaken to evaluate the effect of plasma cholesterol lowering on the progression of atherosclerosis in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbit. The effect of cholesterol lowering, which was accomplished by thermofiltration (on-line plasma separation with plasma filtration at 39 degrees C) was evaluated by comparison between treated and untreated control groups. Thermofiltration reduced significantly the mean plasma level of total cholesterol (284 vs. 655 mg/dl, P = 0.0005) and the percent aortic area occupied by atherosclerotic plaque (15.0 vs. 44.2%, P = 0.0003). The total lipid and cholesterol contents in the aortas in the treated group were also significantly lower than those in the control group. Microscopically, thickness measurements of the lesions showed that the mean thickness of the fibrous cap and the ratio of the thickness of the intima to that of the media were smaller for the treated group than the control group. This study demonstrated the slowing or stopping of the progression of atherosclerosis by lowering the plasma total cholesterol level in WHHL rabbits.
A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells (2008)

Overall, the results obtained from the present study suggest that huKO can be used as a valuable and versatile red fluorescent marker for HSCs.
High-Resolution Micropatterned Teflon AF Substrates for Biocompatible Nanofluidic Devices (2011)

We describe a general photolithography-based process for the microfabrication of surface-supported Teflon AF structures. Teflon AF patterns primarily benefit from superior optical properties such as very low autofluorescence and a low refractive index. The process ensures that the Teflon AF patterns remain strongly hydrophobic in order to allow rapid lipid monolayer spreading and generates a characteristic edge morphology which assists directed cell growth along the structured surfaces. We provide application examples, demonstrating the well-controlled mixing of lipid films on Teflon AF structures and showing how the patterned surfaces can be used as biocompatible growth-directing substrates for cell culture. Chinese hamster ovary (CHO) cells develop in a guided fashion along the sides of the microstructures, selectively avoiding to grow over the patterned areas.
Asymptotic Analysis Of The Total Least Squares ESPRIT Algorithm' (1989)

This paper considers the problem of estimating the parameters of multiple narrowband signals arriving at an array of sensors. Modern approaches to this problem often involve costly procedures for calculating the estimates. The ESPRIT (Estimation of Signal Parameters via Rotational Invariance Techniques) algorithm was recently proposed as a means for obtaining accurate estimates without requiring a costly search of the parameter space. This method utilizes an array invariance to arrive at a computationally efficient multidimensional estimation procedure. Herein, the asymptotic distribution of the estimation error is derived for the Total Least Squares (TLS) version of ESPRIT. The Cramer-Rao Bound (CRB) for the ESPRIT problem formulation is also derived and found to coincide with the variance of the asymptotic distribution through numerical examples. The method is also compared to least squares ESPRIT and MUSIC as well as to the CRB for a calibrated array. Simulations indicate that the theoretic expressions can be used to accurately predict the performance of the algorithm.
Dual-Mode Chirp Spread Spectrum Modulation (2022)

In this letter, we propose dual-mode chirp spread spectrum (DM-CSS) modulation for low-power wide-area networks. DM-CSS is capable of achieving a higher spectral efficiency (SE) relative to its counterparts, such as Long Range (LoRa) modulation. Considering the same symbol period, the SE in DM-CSS are augmented by: (i) simultaneously multiplexing even and odd chirp signals; (ii) using phase shifts of \(0\) and \(π\) radians for both even and odd chirp signals; and (iii) using either up-chirp or down-chirp signal. The SE increases by up to \(116.66\%\) for the same bandwidth and spreading factor relative to LoRa. We present a complete transceiver architecture along with non-coherent detection process. Simulation results reveal that DM-CSS is not only more spectral efficient but also more energy efficient than most classical counterparts. It is also demonstrated that DM-CSS is robust to phase and frequency offsets.
Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning (2006)

The volume of distribution (VD) in humans of 179 known drug molecules (acids, bases, and neutrals) has been modeled using two biomimetic-binding measurements. The phospholipid binding (log K (IAM)) and the plasma protein binding (log K (HSA)) have been calculated from gradient HPLC retention times on immobilized artificial membrane (IAM) and on human serum albumin (HSA) columns, respectively. The log VD values showed good correlation with the compounds' relative binding to IAM and HSA as follows: log VD=0.44 log K (IAM)-0.22 log K (HSA)-0.66; n=179, r2=0.76, s=0.33, and F=272. It was also observed that positively charged molecules bind relatively more to IAM, while negatively charged ones bind more to HSA, in line with the empirical observation that bases tend to have a larger volume of distribution than acids. These results suggest that with the help of these two simple high throughput HPLC-based biomimetic binding measurements an important in vivo drug disposition property can be estimated for use in early drug discovery.
Military satellite communications : Space-based communications for the global information grid (2006)

M satellite communications (MILSATCOM) systems are critical elements ilitary satellite communications (MILSATCOM) systems are critical elements in DoD's vision for a Global Information Grid (GIG). Modeled after the commercial Internet, the GIG will provide global connectivity to support a broad range of military user applications. Commercial networking technologies, coupled with military-unique radio communications equipment, enable the GIG to support the demands of the highly mobile warfighter operating in complex radio environments. MILSATCOM is divided into three categories-narrowband, wideband, and protected-matching user requirements to suitable frequency bands. APL is active in the development of MILSATCOM systems, leveraging more than 20 years of expertise in satellite communications to ensure the global reach of the GIG.
Tree Fern Cyathea lepifera May Survive by Its Phytotoxic Property (2019)

Cyatheaceae (tree ferns) appeared during the Jurassic period and some of the species still remain. Those species may have some morphological and/or physiological characteristics for survival. A tree fern was observed to suppress the growth of other ligneous plants in a tropical forest. It was assumed that the fern may release toxic substances into the forest floor, but those toxic substances have not yet been identified. Therefore, we investigated the phytotoxicity and phytotoxic substances of <i>Cyathea lepifera</i> (J. Sm. ex Hook.) Copel. An aqueous methanol extract of <i>C. lepifera</i> fronds inhibited the growth of roots and shoots of dicotyledonous garden cress (<i>Lepidum sativum</i> L.), lettuce (<i>Lactuca sativa</i> L.), and alfalfa (<i>Medicago sativa</i> L.), and monocotyledonous ryegrass (<i>Lolium multiflorum</i> Lam.), timothy (<i>Phleum pratense</i> L.), and barnyardgrass (<i>Echinochloa crus-galli</i> (L.) P. Beauv.). The results suggest that <i>C. lepifera</i> fronds may have phytotoxicity and contain some phytotoxic substances. The extract was purified through several chromatographic steps during which inhibitory activity was monitored, and <i>p</i>-coumaric acid and (-)-3-hydroxy-<i>β</i>-ionone were isolated. Those compounds showed phytotoxic activity and may contribute to the phytotoxic effects caused by the <i>C. lepifera</i> fronds. The fronds fall and accumulate on the forest floor through defoliation, and the compounds may be released into the forest soils through the decomposition process of the fronds. The phytotoxic activities of the compounds may be partly responsible for the fern's survival.
Linear Time-Varying Dynamic Systems Optimization via Higher-Order Method: A Sub-Domain Approach (1999)

A new procedure for optimization of linear time-varying dynamic systems has been proposed that uses transformations to embed the dynamic equations explicitly into the cost functional. This leads to elimination of Lagrange multipliers and characterization of the optimality equations by high-order differential equations in the same number of variables as number of control inputs. This procedure requires that the transformation matrix be nonsingular at all time within the domain. This paper extends this procedure to problems where a single nonsingular transformation matrix does not exist over the entire domain. In this paper, the time domain is partitioned into intervals such that a nonsingular transformation exists over each interval. The transformations are used to embed the dynamic equations into the cost functional. Variational analysis of the unconstrained cost functionals results in the optimality equations, which are solved efficiently by weighted residual methods. [S0739-3717(00)00601-2]
Optics and Optoelectronics for QIP. (2006)

Abstract not provided.
Iterative Learning Control With Sensor Fusion for Robots With Mismatched Dynamics and Mismatched Sensing (2012)

The appropriate choice of sensing and how to obtain the desired state information from available sensing for feedback or learning process are essential for most control schemes, including iterative learning control (ILC), to achieve their performance objective. In the multi-joint robots with joint elasticity, the load side joint space measurements are usually not available, even though the load side (end-effector) performance is of ultimate interest. This is termed as mismatched sensing problem. Furthermore, the mismatched uncertainty and mismatched real-time feedback signals in the robots with joint elasticity set further difficulty in achieving high performance. In this paper, a hybrid two-stage model based iterative learning control (ILC) scheme is proposed to deal with the mismatched dynamics. Also, to tackle the mismatched sensing issue, a sensor fusion scheme is developed. An optimization based inverse differential kinematics algorithm and decoupled adaptive kinematic Kalman filter (KKF) are integrated to obtain load side joint space information from the insufficient end-effector measurements. The proposed ILC scheme together with the load side state estimation algorithm is validated through the experimental study on a 6-DOF industrial robot.© 2012 ASME
Supplementary Figure 4 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells (2023)

Supplementary Figure 4 from MiR-122/Cyclin G1 Interaction Modulates p53 Activity and Affects Doxorubicin Sensitivity of Human Hepatocarcinoma Cells
Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US (2022)

These findings suggest that at current expected prices, neither aducanumab nor donanemab would be cost-effective for early AD in the US. Donanemab's dosing scheme, in which patients suspend treatment on achieving substantial amyloid reductions, may provide a rubric by which sufficiently effective anti-amyloid antibody treatments could be cost-effective even when priced comparably to other biologics.
From the Editor - National Initiatives and The ECS (1993)

With the recently announced scientific agenda of the Clinton Administration, it appears that The Electrochemical Society and its members are in an excellent position to play a major role in achieving those objectives.
Polymer in-line fiber modulators for broadband radio-frequency optical links (1998)

We present a polymer in-line fiber modulator with a rugged and low-loss interface to single-mode fibers that can be engineered to have a bias point that yields linear modulation over a large dynamic range. Two classes of large-bandwidth modulators, each of which benefits from different properties provided by polymers, are demonstrated. A lumped capacitor modulator, which uses a decal deposition technique, and a traveling-wave modulator, which takes advantage of polymer conformal coating and reactive ion etching to accurately trim the thickness of the polymer waveguide, are presented. Because the in-line fiber modulator configuration requires moderate loss to achieve a large dynamic range, an operational wavelength closer to the absorption peak of an electro-optic polymer can be used to exploit the resonant enhancement of electro-optic coefficients.
Functional inhibition of β-catenin-mediatedWnt signaling by intracellular VHHantibodies (2014)

The Wnt signaling pathway is of central importance in embryogenesis, development and adult tissue homeostasis, and dysregulation of this pathway is associated with cancer and other diseases. Despite the developmental and potential therapeutic significance of this pathway, many aspects of Wnt signaling, including the control of the master transcriptional co-activator β-catenin, remain poorly understood. In order to explore this aspect, a diverse immune llama VHH phagemid library was constructed and panned against β-catenin. VHH antibody fragments from the library were expressed intracellularly, and a number of antibodies were shown to possess function-modifying intracellular activity in a luciferase-based Wnt signaling HEK293 reporter bioassay. Further characterization of one such VHH (named LL3) confirmed that it bound endogenous β-catenin, and that it inhibited the Wnt signaling pathway downstream of the destruction complex, while production of a control Ala-substituted complementarity-determining region (CDR)3 mutant demonstrated that the inhibition of β-catenin activity by the parent intracellular antibody was dependent on the specific CDR sequence of the antibody.
Anodal Transcranial Direct Current Stimulation Transiently Improves Contrast Sensitivity and Normalizes Visual Cortex Activation in Individuals With Amblyopia (2013)

These preliminary results suggest that a-tDCS deserves further investigation as a potential tool to enhance amblyopia treatment outcomes in adults.
Expedient Synthesis of 3,4-Dihydroquinazolines via Tandem Addition — Conjugate Addition Cyclization of Carbodiimides Bearing a Michael Acceptor (2011)

Michael acceptor-possessing N-phenylcarbodiimides, which were prepared by an aza-Wittig reaction of the corresponding functionalized iminophosphoranes with aromatic and aliphatic isocyanates, reacted with enolate carbon-nucleophiles of active methylene compounds via the tandem cumulene addition-hetero (NH) Michael addition cyclization, to provide 2,3,4-trisubstituted 3,4-dihydroquinazolines.It was also found that 2-aminoquinolines and 2-amino-3,4-dihydroquinolines were competitively formed in some cases.Based on these observations, possible mechanistic pathways leading to these heterocycles are proposed.R 2 Conditions Yield (%) 5B 1 4a Ph CH 2 Cl 2 , rt, 2 h 5Aa/97 1 4a Ph CH 2 Cl 2 , rt, 1 h 5Ba/96 2 4b p-Tol CH 2 Cl 2 , rt, 2 h 5Ab/80 2 4b p-Tol CH 2 Cl 2 , rt, 1 h 5Bb/93 3 4c p-MeOC 6 H 4 CH 2 Cl 2 , rt, 7 h 5Ac/85 3 4c p-MeOC 6 H 4 CH 2 Cl 2 , rt, 4 h 5Bc/81 4 4d Bn CH 2 Cl 2 , rt, 5 h 5Ad/84 4 4d Bn CH 2 Cl 2 , rt, 8 h 5Bd/99 5 4e n Pr (CH 2 Cl) 2 , 80 °C, 10 h 5Ae/90 5 4e n Pr (CH 2 Cl) 2 , 80 °C, 5 h 5Be/92 6 4f i Pr (CH 2 Cl) 2 , 70 °C, 9 h 5Af/91 6 4f i Pr (CH 2 Cl) 2 , 70 °C, 8 h 5Bf/92 7 4g c Hex Toluene, 110 °C, 5 h 5Ag/97 7 4g c Hex (CH 2 Cl) 2 , 80 °C, 11 h 5Bg/99 8 4h t Bu (CH 2 Cl) 2 , 80 °C, 11 h 5Ah/60 8 4h t Bu (CH 2 Cl) 2 , 80 °C, 54 h 5Bh/86 9 4i Allyl (CH 2 Cl) 2 , 80 °C, 6 h 5Bi/95When carbodiimides 5Aa-e bearing an acrylonitrile moiety (R 1 = CN) were allowed to react with enolate generated from diethyl malonate (6a), dihydroquinazolines 7a-e were obtained as exclusive products, as expected (Table 2a).In contrast, in the reaction of 5Ah (R 2 = t Bu) with 6a, 2-(t-butylamino)quinoline-3-carboxylic ethyl ester (8h) was formed as the sole product instead of the expected product 7h.The same tendency was observed in the reactions of 5Aa-h with cyanoacetate (6b) (Table 2b).Namely, dihydroquinazolines 9a-g were preferentially formed when the substituent R 2 was relatively less bulky, whereas the predominant formation of 2-(t-butylamino)quinoline-3-carbonitrile (10h) was observed in the reaction of 5Ah involving the bulky t Bu group.The fact that formation of
A tunable universal terahertz filter using artificial dielectrics based on parallel-plate waveguides (2010)

Using parallel-plate waveguides (PPWGs) that mimic artificial dielectrics, we demonstrate a universal filter that provides low-pass, high-pass, band-pass, and band-stop (or notch) filtering functionalities in the terahertz (THz) frequency regime. The device essentially consists of two PPWGs in a complementary geometry. The filtering functionality is achieved by positioning an appropriate amplitude mask in the path of the spatially chirped THz beam between the two waveguides. By varying the position of the mask, we experimentally and theoretically demonstrate continuous tunability of the respective 3 dB cutoff frequencies within the frequency range from about 0.3 to 0.7 THz.
An intercell interference power level feedback technique for one-cell reuse TDMA systems with OFDM-based adaptive modulation scheme (2006)

To implement a one-cell reuse time division multiple access (TDMA) system using orthogonal frequency division multiplexing-based adaptive modulation scheme (OFDM AMS) and multilevel transmit power control (MTPC), co-channel interference [intercell interference (ICI)] from adjacent cells that varies dynamically on the frequency axis must be fed back very accurately to the transmitting station. Therefore, in this paper, we propose an ICI feedback technology in one-cell reuse TDMA with OFDM AMS/MTPC. First, the interference power of each subchannel is estimated by calculating the vector error which is the difference between the reference symbol on the receiving side and the received symbol. Next, instead of a digital signal method capable of expanding the amount of information, analog quadrature amplitude modulation (QAM) is adopted in order to feed back the errors with high accuracy. In addition, code division multiplexing (CDM) is adopted in order to improve the robustness to multipaths. Furthermore, to reduce the amount of feedback information, we adopt a method where the estimated interference noise power is formed into blocks by multiple adjacent subcarriers, and only the average of the block is set as the notification target, and interference power information less than some constant value is not notified. The evaluation results of the characteristics of the proposed method by a computer simulation verified that the interference noise power can be estimated very accurately and can accurately notify by using a notification frame with optimized power distribution. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 89(7): 11–23, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20281
A Direct Comparison between Heterogeneously Integrated Widely-Tunable Ring-Based Laser Designs (2017)

Four ring-based tunable laser structures are firstly demonstrated in the heterogeneous integrated silicon platform. Except for double-sided coupled-ring structure, the other three ones show comparable narrow-linewidth (~200kHz) and output power (~10mW) across entire wide-tuning ranges (~40nm) with high side-mode suppression ratio (&gt;40 dB).
Elastic Metro Ethernet and Elastic Cloud Services (2021)

Lifecycle Services Orchestration (LSO) architecture for Metro Ethernet Services was introduced by MEF. In the LSO architecture, the ALLEGRO interface was defined for dynamic service control between customer and Service Provider while the INTERLUDE interface was defined between Orchestrators of two Operators to initiate a technical operation or dynamic service control. In order to address dynamic control of services supported by networks of multiple operators over ALLEGRO and INTERLUDE interfaces, Elastic E-Line Service was introduced by the author in MEF. In addition, Cloud Services Architecture was introduced as an architectural framework for virtual services by the author. In this paper, we describe LSO architecture and Elastic E-Line Service concept, and interactions between various LSO entities for dynamic service provisioning. After that, we describe Cloud Services Architecture and dynamic modifications of Elastic Cloud Services over ALLEGRO and INTERLUDE interfaces, for the first time.
Doubly N‐Fused Porphyrin (2008)

Are you N-fused? Doubly N-fused porphyrin (see picture; Br red, F green, N blue) exhibits exceptionally long-wavelength absorption for an 18π aromatic system (in excess of 1600 nm). The HOMO–LUMO energy gap of doubly N-fused porphyrin is extremely small for an [18]annulenic compound and results from endocyclic extension of the porphyrin π system.