gebhart/patrepeval huggingface dataset:
Research Note: Evaluation of quinine as a chemoprophylactic candidate against histomoniasis in turkeys (2021)

Histomoniasis, also commonly referred to as blackhead disease, is caused by the protozoan parasite Histomonas meleagridis. Since the removal of nitarsone in 2015, no approved prophylactics are available for mitigating histomoniasis. Disease incidence and high mortalities are frequently associated with turkey flocks, although infection of broiler breeders also occurs. Quinine is a naturally occurring alkaloid with antimalarial properties. In vitro assays have shown strong antihistomonal properties of quinine, leading to our hypothesis that quinine inclusion within the feed could prevent histomoniasis in turkeys. Selected concentrations of quinine were included within a turkey starter diet to evaluate effects on body weight gain (BWG), liver lesions, cecal lesions, and mortality of H. meleagridis-challenged turkeys. On day-of-hatch, poults were randomly assigned to either the basal diet or a quinine diet. Groups consisted of a non-challenged control (NC; basal diet), 0.022% quinine + challenge, 0.067% quinine + challenge, 0.2% quinine + challenge, or a positive-challenged control (PC; basal diet). On d 10, challenged groups were intracloacally inoculated with 10<sup>5</sup>H. meleagridis cells/turkey, and lesions were evaluated on d 21 post-infection. Individual body weights were recorded on d 0, d 10, and d 31 to calculate the pre-challenge and post-challenge BWG. No significant differences (P > 0.05) were observed between the d 0 to 10 pre-challenged BWG between quinine treatment diets and the basal diet. Similarly, no differences (P > 0.05) were observed in post-challenge d10-31 BWG of the quinine dietary treatments as compared to the PC. Cumulative mortalities, liver lesions, and cecal lesions related to histomoniasis were not reduced (P > 0.05) in any of the quinine treatment groups as compared to the PC. Although quinine successfully reduced H. meleagridis cells in vitro, results from the in vivo experiment indicated no reduction in histomoniasis severity as evidenced by similar lesions and mortality as the PC. Taken together, these data indicate that quinine inclusion within the feed at these concentrations and under these experimental conditions was not efficacious in the prevention or treatment of histomoniasis.
A Pseudo-Rigid-Body Model for Initially-Curved Pinned-Pinned Segments Used in Compliant Mechanisms (1999)

The pseudo-rigid-body model concept allows compliant mechanisms to be analyzed using well-known rigid-body kinematics. This paper presents a pseudo-rigid-body model for initially curved pinned-pinned segments that undergo large, nonlinear deflections. The model approximates the segment as three rigid members joined by pin joints. Torsional springs placed at the joints model the segment’s stiffness. This model has been validated by fabricating several such segments from a variety of different materials. Testing of the force-deflection behavior of these segments verified the accuracy of the model.
CW operation of III&#x2013;V microdisk lasers on SOI fabricated in a 200 mm CMOS pilot line (2011)

Compact InP-based microdisk lasers on SOI completely fabricated in a 200 mm CMOS pilot line are presented. Continuous wave operation is demonstrated with threshold currents of 600 μA and 31 μW output power.
Agent with Rule Engine: The "Glue' for Web Service Oriented Computing Applied to Network Management (2009)

Service Oriented Computing (SOC) is the fast emerging successor of the Object Oriented Computing design paradigm. Web Services technology, which is considered as an implementation of the SOC model, has had an incredible acceptance but tumultuous growth. This apparent chaos is due to its inherent lack of flexible cooperation strategies, generic service model and weak semantic description, mainly when deployed for Enterprise Applications with distributed computing transactions. Agent Based Web Services(AWS) is an appropriate approach to implement the Enterprise-Agent Design Model, which aims to overcome these inherent limitations of Web Services. In this paper, we report our ongoing efforts to use AWS in a Network Management System(NMS) we have built. Our NMS employs both SNMP and Mobile Agents(Aglets). We are developing an intelligent software agent, which is integrated with the Drools Rule Engine so that appropriate rules are triggered when pre-defined events occur. Our work is a novel approach covering a multitude of technologies such as SOC, AWS, Rule Engine, SNMP and Mobile Agents, with our Software Agent acting as a `glue' imbibing this synergy.
Supplementary Table 3 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers (2023)

Supplementary Table 3 from Characterization of the Methylation Patterns in Human Papillomavirus Type 16 Viral DNA in Head and Neck Cancers
Total instantaneous energy transport in polychromatic fluid gravity waves at finite depth (2012)

The total instantaneous energy transport can be found for polychromatic waves when using the deep water approximation. Expanding this theory to waves in waters of finite depth, we derive an expression for the total instantaneous energy transport for polychromatic fluid gravity waves based on potential theory with linearized free surface boundary conditions. We present the results for time series of wave elevation measured at the Uppsala University wave energy research test site. We show that a significant proportion of the total instantaneous energy transport is not accounted for when using the deep water theory. This is important since many wave energy conversion devices under development will operate in waters that do not fulfil the deep water criteria.
Controlling the All-trans Stereochemistry in Liquid Crystalline 4,4′-Dialkyl-[1,1′-bicyclohexyl] Compounds (2020)

A good part of today’s liquid crystals (LCs) for display applications are derived from the Darzens–Nenitzescu reaction which, in a one-pot-process, yields 1,4-trans-acylphenylcyclohexanes from acid chlorides, benzene, and cyclohexene. A mechanism for this process is proposed based on quantum-chemical computations. The products of this reaction can be further elaborated to all-trans-4,4′-disubstituted-[1,1′-bicyclohexane] compounds, essential components in almost all fast switching LC-mixtures. An equilibration process involving carbo­cations is used to control the diastereomer distribution.
Efficiency and Forward Voltage of Blue and Green Lateral LEDs with V-defects in Quantum Wells (2021)

For nitride-based blue and green light-emitting diodes (LEDs), the forward voltage $V_\text{for}$ is larger than expected, especially for green LEDs. This is mainly due to the large barriers to vertical carrier transport caused by the total polarization discontinuity at multiple quantum well and quantum barrier interfaces. The natural random alloy fluctuation in QWs has proven to be an important factor reducing $V_\text{for}$. However, this does not suffice in the case of green LEDs because of their larger polarization-induced barrier. V-defects have been proposed as another key factor in reducing $V_\text{for}$ to allow laterally injection into multiple quantum wells (MQWs), thus bypassing the multiple energy barriers incurred by vertical transport. In this paper, to model carrier transport in the whole LED, we consider both random-alloy and V-defect effects. A fully two-dimensional drift-diffusion charge-control solver is used to model both effects. The results indicate that the turn-on voltages for blue and green LEDs are both affected by random alloy fluctuations and V-defect density. For green LEDs, $V_\text{for}$ decreases more due to V-defects, where the smaller polarization barrier at the V-defect sidewall is the major path for lateral carrier injection. Finally, we discuss how V-defect density and size affects the results.
Establishing microbial composition measurement standards with reference frames (2019)

Abstract Differential abundance analysis is controversial throughout microbiome research. Gold standard approaches require laborious measurements of total microbial load, or absolute number of microorganisms, to accurately determine taxonomic shifts. Therefore, most studies rely on relative abundance data. Here, we demonstrate common pitfalls in comparing relative abundance across samples and identify two solutions that reveal microbial changes without the need to estimate total microbial load. We define the notion of “reference frames”, which provide deep intuition about the compositional nature of microbiome data. In an oral time series experiment, reference frames alleviate false positives and produce consistent results on both raw and cell-count normalized data. Furthermore, reference frames identify consistent, differentially abundant microbes previously undetected in two independent published datasets from subjects with atopic dermatitis. These methods allow reassessment of published relative abundance data to reveal reproducible microbial changes from standard sequencing output without the need for new assays.
Unsupervised Learned Kalman Filtering (2021)

In this paper we adapt KalmanNet, which is a recently pro-posed deep neural network (DNN)-aided system whose architecture follows the operation of the model-based Kalman filter (KF), to learn its mapping in an unsupervised manner, i.e., without requiring ground-truth states. The unsupervised adaptation is achieved by exploiting the hybrid model-based/data-driven architecture of KalmanNet, which internally predicts the next observation as the KF does. These internal features are then used to compute the loss rather than the state estimate at the output of the system. With the capability of unsupervised learning, one can use KalmanNet not only to track the hidden state, but also to adapt to variations in the state space (SS) model. We numerically demonstrate that when the noise statistics are unknown, unsupervised KalmanNet achieves a similar performance to KalmanNet with supervised learning. We also show that we can adapt a pre-trained KalmanNet to changing SS models without providing additional data thanks to the unsupervised capabilities.
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2AReceptor Antagonists and Their Biological Evaluation (2017)

Our initial structure-activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy-2-methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and selective A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AdoR) antagonist with reasonable ADME and pharmacokinetic properties. However, poor intrinsic solubility and low to moderate oral bioavailability made this series unsuitable for further development. Further optimization using structure-based drug design approach resulted in discovery of potent and selective adenosine A<sub>2A</sub> receptor antagonists bearing substituted 1-methylcyclohexyl-carboxamide groups at position 2 of the benzothiazole scaffold and endowed with better solubility and oral bioavailability. Compounds 41 and 49 demonstrated a number of positive attributes with respect to in vitro ADME properties. Both compounds displayed good pharmacokinetic properties with 63% and 61% oral bioavailability, respectively, in rat. Further, compound 49 displayed oral efficacy in 6-OHDA lesioned rat model of Parkinson diseases.
Processes Using Supercritical Fluids: A Sustainable Approach for the Design of Functional Nanomaterials (2007)

The concepts of green chemistry and sustainable development are being considered more and more due to the evolution of regulations and mentalities. In this context, the development of supercritical fluid technologies should go on to evolve in the right direction.Since the nineteen fifties, studies and development efforts have been focused on new ways of separating substances using the specific properties of supercritical fluids. In this context, a mention must be made about the use of carbon dioxide as an extracting agent in many industrial processes (decaffeination of coffee and tea, extraction of hops, spice, aromatic substances, fragrances, pharmaceuticals, etc). Processes using these fluids are particularly attractive at the industrial scale in many fields such as impregnation, analytical and preparative separations, organic synthesis, waste management and material recycling. The industrial development of the supercritical fluid technology is accompanied by numerous research activities, in particular, in the field of inorganic Materials Science for the synthesis of multifunctional nanomaterials.Today, supercritical fluid technology allows the production, with a reduction of the environmental impact, of well designed nanomaterials with controlled properties for applications in many interesting fields, such as catalysis, electronics, energy, optics, pharmacology, etc. This paper is focused on the interest of using supercritical fluids to overcome the drawbacks of solution chemistry approaches for designing multifunctional nanomaterials in term of chemical engineering, sustainable chemistry and control of size, morphology, composition and the structure of nanomaterials.
Résultats récents concernant l'imagerie par fibres optiques (2011)

National audience
Process analysis of spray atomization of dissolved polymers for manufacturing of blood-compatible textile implants (2017)

The use of porous polymer materials for vascular prostheses demonstrates promising results. Fleece-like non-woven structures can be generated by atomization of dissolved polycarbonate urethanes. This article focuses on the manufacturing process for the fleece structures. The solution is atomized through a high-volume low-pressure nozzle. The solvent evaporates during time of flight to target, so that small fibres are formed from each drop of solution. By using different rotating molds and positioning systems, tubular shapes or open surfaces can be generated. The manufacturing process is described in detail. The usability of different grades of polycarbonate urethane is tested and the time necessary for evaporation of the solvent from the mesh is assessed. The influence of several basic parameters on the mechanical properties of the generated non-woven material is analysed and discussed.
A cellular automata model of electrical propagation in cardiac tissue (2002)

A cellular automata model of cardiac tissue is created which overcomes many of the limits of previous models. Rather than simply simulating one or a few aspects of tissue behavior, this model is generalized to include the possibility of a vast array of different tissue characteristics. In addition, the computer program used to implement this model has been written to allow easy addition or alteration to the model, with minimal or no source code rewriting. The major strength of this model comes from the basis of its description of tissue behavior. It does not try to represent each element in the model as an amount of tissue, instead it considers each element to be a sampled point in the tissue. The creation of this model 'engine' permits a specific anatomical implementation to be created quickly, without sacrificing desired accuracy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
52-Week Efficacy of Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis Who Failed Corticosteroids and/or Immunosuppressants (2013)

In this open-label study, adalimumab was effective for maintaining clinical remission in anti-tumor necrosis factor-naive patients with moderately to severely active ulcerative colitis who did not adequately respond to conventional therapy.
SNZI (2007)

We introduce the SNZI shared object, which is related to traditional shared counters, but has weaker semantics. We also introduce a resettable version of SNZI called SNZI-R. We present implementations that are scalable, linearizable, nonblocking, and fast in the absence of contention, properties that are difficult or impossible to achieve simultaneously with the stronger semantics of traditional counters. Our primary motivation in introducing SNZI and SNZI-R is to use them to improve the performance and scalability of software and hybrid transactional memory systems. We present performance experiments showing that our implementations have excellent performance characteristics for this purpose.
Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands (2007)

Asymmetric hydrogenation of unsaturated urea esters with the BIPI Ligands has been examined. Optimization of the P-N ligand structure has led to the development of chiral rhodium catalysts capable of producing the targets with >99% ee. The critical phosphine borane SNAr reaction needed for ligand synthesis has been optimized to give the adducts in high yield at ambient temperature with no racemization. An extremely concise, economical, and scalable sequence to these important new ligands for catalysis of asymmetric hydrogenation has been developed.
ChemInform Abstract: Synthesis and Investigations of Enetetraynes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adaptive Pulse Repetition Frequency Technique for an Ultrasonic Transit-Time Gas Flowmeter for Hot Pulsating Gases (2006)

A technique of using an adaptive pulse repetition frequency (PRF) to operate an ultrasonic contrapropagation transit-time gas flowmeter (UFM) is introduced. This adaptive PRF technique allows transient measurements of hot (up to 450 degC) and pulsating (up to 1.5 kHz) gas flows. Such conditions occur in the exhaust gas of a combustion engine. Here, a UFM with the widely used fixed PRF technique is not applicable, because the large gas temperature variations would prevent a reliable detection of ultrasonic pulse arrival times. Coherently reflected waves are generated within the gas because of the unavoidable acoustic impedance mismatch between the gas and the transducers, and, depending on the gas temperatures, these echoes overlap with the main signal. The adaptive PRF technique overcomes this problem and allows correct pulse detection over the whole temperature range required. The UFM utilizes special high-temperature-resistant capacitance ultrasonic transducers (CUTs) to meet the requirements in terms of operating temperature range and dynamic response. Results, which are obtained with a preliminary laboratory prototype, are presented for the exhaust gas mass flow rate in a otimes 50-mm pipe measured at gas temperatures of up to 450 degC and at PRFs of up to 5.5 kHz, which is an increase in frequency response of one order of magnitude in comparison to existing measurement systems
E-cadherin modulation by soluble IL-15 controls epithelial-mesenchymal transition on renal epithelial cells. (2015)

&lt;p&gt;&lt;b&gt;A&lt;/b&gt;) Immunofluorescence of cell–cell adhesion molecules show that IL-15 favors epithelial-mesenchymal transition (EMT) on RCC7, whereas it preserves the EMT commitment of RPTEC. The medium culture of RPTEC was not changed in order to induce the EMT process. Cells stimulated or not with 10 pg/ml of rhIL-15 for 5 days, were fixed and stained using standard immunofluorescence procedures with Abs against epithelial (cytokeratins and ZO-1) and mesenchymal markers (F-actin, ASO2 and vimentin). Similar results were obtained using different RCC (RCC5, RCC8) and RPTEC batches. &lt;b&gt;B&lt;/b&gt;) After 48 h, transfected RCC were treated for an additional 48 h with 10 pg/mL of rhIL-15 before evaluating the epithelial (cytokeratins) and mesenchymal (vimentin) markers expression by flow cytometry. RhIL-15 induced EMT was counterbalanced only in IL-2Rγ/JAK3 co-transfected RCC. Mean fluorescence intensity values for each marker are shown in each histogram. Results are representative of three experiments.&lt;/p&gt;
Switched-Current Analog Programmable Filter for Software-Defined Radio (2003)

We have proposed a switched-current (SI) analog programmable finite-impulse-response (FIR) filter for software-defined radio. The programmable tap coefficient circuit for programmable operation of the SI FIR filter has also been proposed. The 4-bit-resolution tap coefficient circuit has been designed and fabricated using 0.35 µm complementary-metal-oxide-semiconductor technology. The current error between measured and calculated tap coefficient circuits has been less than 2%. The radio frequency/intermediate frequency SI band-pass filter has been designed using the measured tap coefficients. The designed SI FIR filter has a frequency response as well as calculated tap coefficients. The maximum operating frequency of the proposed SI FIR filter using 0.13 µm CMOS technology has been estimated to be greater than 10 GHz with circuit simulation.
INTER‐LABORATORY VARIATIONS IN URINARY OESTRIOL ESTIMATES (1974)

Summary A survey was made of the results reported from 23 New Zealand laboratories which carry out oestriol determinations on pregnancy urine specimens. All laboratories use methods based on the Kober reaction, but five different preliminary extraction procedures are used. The type of standard and stage at which it is incorporated in the procedure also varies. In consequence, the oestriol content reported to the clinician depends on the laboratory carrying out the assay as well as on excretion. Most laboratories were found to report consistent results over twelve specimens with widely different oestriol contents. Thus the inter‐laboratory variation does not affect the usefulness of serial urine oestriol determinations, provided all analyses are carried out in the same laboratory. A minority of laboratories produced inconsistent results, but in all but two cases these were confined to one batch of analyses, and thus the inconsistency reflects inadequate quality control rather than technical inability to carry out the assay.
Sensitivity of MIMO controller performance to model-plant mismatch, with applications to paper machine control (2014)

Model-based controllers based on incorrect estimates of the true plant behaviour can be expected to perform badly. This work quantifies the performance deterioration for a certain class of MIMO systems. Performance is measured using a Minimum Variance index and a closely related user-specified criterion. Under reasonable conditions, the performance of each output component in a MIMO system can be analysed independently. We define a sensitivity measure that relates system performance to model-plant mismatch, and use it to explore this sensitivity for three realistic types of parametric modelling errors. Next, we suggest a quantitative method that compares a system's actual output to its desired response in a transient setting. The performance of the transient response is demonstrably more sensitive to the model-plant mismatch than the steady state performance. The results are illustrated on industrial paper machine data.