gebhart/patrepeval huggingface dataset:
Expectations for Manuscripts with Nanoscience and Nanotechnology Elements in ACS Sustainable Chemistry & Engineering (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTExpectations for Manuscripts with Nanoscience and Nanotechnology Elements in ACS Sustainable Chemistry & EngineeringThalappil PradeepThalappil PradeepMore by Thalappil Pradeephttp://orcid.org/0000-0003-3174-534X, David T. AllenDavid T. AllenMore by David T. Allenhttp://orcid.org/0000-0001-6646-8755, Peter LicencePeter LicenceMore by Peter Licencehttp://orcid.org/0000-0003-2992-0153, and Bala SubramaniamBala SubramaniamMore by Bala Subramaniamhttp://orcid.org/0000-0001-5361-1954Cite this: ACS Sustainable Chem. Eng. 2020, 8, 21, 7751–7752Publication Date (Web):June 1, 2020Publication History Received4 May 2020Published online1 June 2020Published inissue 1 June 2020https://pubs.acs.org/doi/10.1021/acssuschemeng.0c03316https://doi.org/10.1021/acssuschemeng.0c03316editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4452Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (640 KB) Get e-AlertscloseSUBJECTS:Materials,Nanomaterials,Nanoscience,Nanotechnology,Sustainability Get e-Alerts
[Advances of neuroimaging research and the development of pathophysiology hypothesis for obsessive-compulsive disorder]. (2011)

Hypotheses of pathophysiology in obsessive-compulsive disorder (OCD) have developed in parallel with advances in neuroimaging. Based on findings from early PET and SPECT studies evaluating cerebral blood flow and glucose metabolism, one theory proposed involvement of the orbitofrontal-striatum-thalamus loop (the "OCD loop"), which is relevant to the enforced learning and maintenance of OC symptoms. This OCD loop hypothesis has been revised in accordance with advances in neuroimaging techniques and the accumulation of findings. PET and SPECT molecular neuroimaging studies have provided the biological evidence to support the serotonin and dopamine hypotheses that were based on psychopharmacological findings. A symptom dimension hypothesis, based on symptomatology, has also been proposed. Neuroimaging has revealed the distinct neural basis of each symptom dimension. Neuroimaging has contributed to understanding the pathophysiology of OCD, and is expected to contribute to the development of treatment.
Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications:  Terphenyl Diamidines and Analogues (2006)

Diamidines 10a-g and 18a,b were obtained from dinitriles 9a-g and 15a,b by treatment with lithium trimethylsilylamide or upon hydrogenation of bis-O-acetoxyamidoximes. Dinitriles 9a-g were prepared via Suzuki reactions between arylboronic acids and arylnitriles. Potential prodrugs 12a-f and 17 were prepared via methylation of the diamidoximes 11a-f and 16a. Significant DNA affinities for rigid-rod molecules were observed. Compounds 10a, 10b, 10d, 18a, and 18b show IC50 values of 5 nM or less against Trypanosoma brucei rhodesiense (T. b. r.) and 10a, 10b, 10e, 18a, and 18b gave similar ones against Plasmodium falciparum (P.f.). The dications, 10a, 10d, 10f, and 10g are more active than furamidine in vivo. The prodrugs are only moderately effective on oral administration. Mouse liver microsome bioconversion of the methamidoxime prodrugs is significantly reduced from that of pafuramidine and suggests that the in vivo efficacy of these prodrugs is, in part, due to poor bioconversion.
Atomic Layer Deposition of Tungsten Disulphide Solid Lubricant Nanocomposite Coatings on Rolling Element Bearings (2009)

Atomic layer deposition (ALD) has the potential to provide highly conformal coatings with precise control of thickness. This article describes the application of ALD nanocomposite containing ZnF2 in WS2 matrix solid lubricant coatings on fully assembled rolling element bearings. The torque behavior of the coated bearings was studied during oscillatory contacts and after exposure to vibration. The coatings exhibited a hexagonal layered structure with predominant preferentially orientated (002) basal planes. These basal planes when sheared imparted very low running torque values of ∼ 0.5 mN· m in dry nitrogen. The outer race, inner race, and ball surfaces showed WS2 transfer film protection on the native coating necessary to achieve low torque in dry nitrogen. Structural (re)ordering of the basal and prismatic planes with multiple random and branched orientations was observed through the thickness of the transfer films. There was no evidence of uniformly aligned c-axis perpendicular-orientated basal planes on the transfer film surface. The unique advantages of ALD to apply solid lubricant coatings on rolling elements of fully assembled miniature bearings are compared with conventional solid lubrication techniques.
Mode shaping of a graded-reflectivity-mirror unstable resonator with an intra-cavity phase element (2001)

A graded-reflectivity-mirror (GRM) unstable resonator with low output coupling is described, where a custom-made optical phase element is used inside the resonator to provide maximally flat output. The phase element removes the dip in the output beam by pre-compensating the internal Gaussian mode. An experiment is performed with a flashlamp-pumped Nd:YAG laser. The resonator's magnification (M) and the GRM's central reflectivity (R/sub 0/) are 2.3 and 0.7, respectively. The large dip in the center of the output is removed using the custom-made phase element. This resonator has the advantage over a conventional GRM unstable resonator of being suitable for lower-gain laser media. The gain required to overcome fundamental mode cavity losses for maximally flat output is decreased from 22.3 (for a conventional GRM resonator) to 4.3 (for the resonator containing the phase element). This reduction in required gain comes with essentially no loss to the resonator modal discrimination.
TNF-α inhibits liver collagen-α1(I) gene expression through a tissue-specific regulatory region (1998)

Although tumor necrosis factor-alpha (TNF-alpha) inhibits collagen-alpha 1(I) gene expression in cultured hepatic stellate cells, assessment of its effects on hepatic collagen expression is complicated by the confounding variables of tissue necrosis and inflammation. Therefore, we analyzed whether chronically elevated serum TNF-alpha affects constitutive hepatic collagen metabolism in vivo by inoculating nude mice with Chinese hamster ovary (CHO) cells secreting TNF-alpha (TNF-alpha mice) or with control CHO cells (control mice). Before the onset of weight loss, collagen synthesis and collagen gene expression were inhibited in the liver of TNF-alpha mice. In transgenic mice, after 8 h, TNF-alpha (500 ng at 0 and 5 h) inhibited the liver expression of the collagen-alpha 1(I)-human growth hormone (hGH) transgene containing the first intron and -440 bp of the 5' region. Similarly, in cultured hepatic stellate cells isolated from these transgenic animals, the -440 bp collagen-alpha 1(I)-hGH transgene was responsive to TNF-alpha treatment independent of the activation of these cells. Transfection studies in stellate cells allowed further characterization of this TNF-alpha-responsive segment to -220 bp of the 5' region. Because in the skin the inhibitory effect of TNF-alpha involves a regulatory region of the collagen-alpha 1(I) gene beyond -440 bp, we herein identify a novel tissue-specific regulation of collagen-alpha 1(I) gene by TNF-alpha.
ChemInform Abstract: Homolytic Acylation of Protonated Pyridines and Pyrazines with α‐ Keto Acids: The Problem of Monoacylation. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital robust controller for DC-DC converter at remote sensing (2008)

If the lines which connect the output terminal of DC-DC converter and the load are long the voltage actually across load will be changed largely to produce the voltage drops by the impedances of the lines. Then, the terminal which senses the voltage across load is prepared apart from the output terminal of DC-DC converter, and it leads to the load, and the voltage across load is adjusted so that it is not changed largely. This method is called remote sensing. When the lines becomes long, the usual method of adjusting the voltage across load cannot suppress enough the change of it. In this paper, the robust digital controller for suppressing the change of the voltage across load is proposed. Experimental studies using DSP demonstrate that this type of digital controller is effective to suppress it.
Effect of Concrete Strength and Minimum Stirrups on Shear Strength of Large Members (2001)

First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Invalid Email Address
Degradation of a nuclear-localized protein in mammalian COS cells, using Escherichia coli beta-galactosidase as a model protein. (1992)

To investigate the mechanism of degradation of proteins localized in the nucleus, we constructed genes encoding modified Escherichia coli beta-galactosidases and expressed them in mammalian COS cells. When the beta-galactosidase with a nuclear localization signal from SV 40 T antigen was expressed in COS cells, the beta-galactosidase polypeptide was localized in the nuclei and was stable for at least 4 h. When 16 amino acid residues were deleted from the C-terminal end, the beta-galactosidase polypeptide was also observed in the nuclei but it was degraded rapidly, with a half-life of 1.6 h. When the nuclear localizing signal was replaced with a mutant sequence, which lacks nuclear targeting activity, the beta-galactosidase polypeptides were present throughout the cells rather than in the nuclei. The beta-galactosidase polypeptide with the complete C terminus was stable and the cytoplasmic truncated polypeptide was degraded at the same rate as the nuclear C terminus truncated polypeptide. The beta-galactosidase polypeptides with the complete C terminus were present as a tetramer as reported previously and had beta-galactosidase activity, but the C terminus truncated polypeptides were present as monomer and had no enzyme activity, indicating that C terminus truncated beta-galactosidase is malfolded. Together, the results suggest that a nuclear-localized malfolded protein is degraded as rapidly as a cytoplasmic malfolded protein.
Supplementary Figure 6 from <i>De Novo</i> Design of a Tumor-Penetrating Peptide (2023)

&lt;p&gt;PDF file - 898K, iNGR does not increase the penetration of co-administered Evans blue dye into normal organs&lt;/p&gt;
Structure and Function of Benzoylurea‐Derived α‐Helix Mimetics Targeting the Bcl‐xL/Bak Binding Interface (2009)

The Bcl-x(L)/Bak protein-protein interaction has emerged as an important target for cancer therapy due to its role in apoptosis. Inhibition of this interaction by small-molecule antagonists induces apoptosis in unhealthy cells. Bak, a pro-apoptotic Bcl-2 protein, projects four hydrophobic side chains (V74, L78, I81, and I85), corresponding to the i, i+4, i+7, and i+11 positions of an alpha-helix, into a hydrophobic cleft on Bcl-x(L). Herein, we present a novel family of rationally designed alpha-helix mimetics with improved solubility and synthetic feasibility based on a benzoylurea scaffold. These benzoylurea derivatives favor a linear conformation stabilized by an intramolecular hydrogen bond, and are able to mimic the spatial projection of the i, i+4, and i+7 residues of an alpha-helix. The binding of the benzoylurea derivatives to Bcl-x(L) was assessed using fluorescence polarization competition assays, isothermal titration calorimetry, and (15)N-HSQC experiments. These experiments showed that these agents bind to and disrupt Bcl-x(L) with low micromolar inhibition and dissociation constants, with (15)N-HSQC experiments confirming binding to the hydrophobic pocket of Bcl-x(L) normally occupied by the Bak helix.
2.3-Tbit/s (23×100-Gbit/s) RZ-DQPSK Grooming Switch (Simultaneous Add/Drop, Data Exchange and Equalization) Using Double-Pass LCoS and Bidirectional HNLF (2011)

We present a 2.3-Tbit/s network switching element by exploiting double-pass LCoS technology and bidirectional nonlinear effects inside a single HNLF. We demonstrate 2.3-Tbit/s grooming switch with simultaneous functions of add/drop, data exchange, and power equalization, for 23-channel 100-Gbit/s RZ-DQPSK signals.
Accelerating the computation of critical eigenvalues with parallel computing techniques (2016)

Eigenanalysis of power systems is frequently used to study the effect and tune the response of existing controllers, or to guide the design of new controllers. However, recent developments in the area lead to the necessity of studying larger power system models, resulting from the interconnection of transmission networks or the joint consideration of transmission and distribution networks. Moreover, these models include new types of controls, mainly based on power electronic interfaces, which are expected to provide significant support in the future. The consequence is that the size and complexity of these models challenge the computational efficiency of existing eigenanalysis methods. In this paper, a procedure is proposed that uses domain decomposition and parallel computing methods, to accelerate the computation of eigenvalues in a selected region of the complex plane with iterative eigenanalysis methods. The proposed algorithm is validated on a small transmission system and its performance is assessed on a large-scale, combined transmission and distribution system.
The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site (1995)

Binding studies with a CD6 immunoglobulin fusion protein (CD6 Rg) resulted in the identification and cloning of a CD6 ligand. This ligand was found to be a member of the immunoglobulin supergene family and was named ALCAM (activated leukocyte cell adhesion molecule). Cell adhesion assays showed that CD6-ALCAM interactions mediate thymocyte-thymic epithelium cell binding. ALCAM is also expressed by activated leukocytes and neurons and may be involved in interactions between T cells and activated leukocytes and between cells of the immune and nervous systems, respectively. Herein we describe the preparation of domain-specific murine CD6 Rg fusion proteins and show that the membrane-proximal SRCR (scavenger receptor cysteine-rich) domain of CD6 contains the ALCAM binding site. We also show that mAbs which bind to this domain preferentially block CD6-ALCAM binding. These results demonstrate that the membrane-proximal SRCR domain of CD6 is necessary for CD6 binding to ALCAM and provide the first direct evidence for the interaction of an SRCR domain with a ligand.
Integration of Clinical Data, Pathology, and cDNA Microarrays in Influenza Virus-Infected Pigtailed Macaques (Macaca nemestrina) (2004)

For most severe viral pandemics such as influenza and AIDS, the exact contribution of individual viral genes to pathogenicity is still largely unknown. A necessary step toward that understanding is a systematic comparison of different influenza virus strains at the level of transcriptional regulation in the host as a whole and interpretation of these complex genetic changes in the context of multifactorial clinical outcomes and pathology. We conducted a study by infecting pigtailed macaques (Macaca nemestrina) with a genetically reconstructed strain of human influenza H1N1 A/Texas/36/91 virus and hypothesized not only that these animals would respond to the virus similarly to humans, but that gene expression patterns in the lungs and tracheobronchial lymph nodes would fit into a coherent and complete picture of the host-virus interactions during infection. The disease observed in infected macaques simulated uncomplicated influenza in humans. Clinical signs and an antibody response appeared with induction of interferon and B-cell activation pathways, respectively. Transcriptional activation of inflammatory cells and apoptotic pathways coincided with gross and histopathological signs of inflammation, with tissue damage and concurrent signs of repair. Additionally, cDNA microarrays offered new evidence of the importance of cytotoxic T cells and natural killer cells throughout infection. With this experiment, we confirmed the suitability of the nonhuman primate model in the quest for understanding the individual and joint contributions of viral genes to influenza virus pathogenesis by using cDNA microarray technology and a reverse genetics approach.
Extraction of Valuable Biomolecules from the Microalga Haematococcus pluvialis Assisted by Electrotechnologies (2023)

The freshwater microalga <i>Haematococcus pluvialis</i> is well known as the cell factory for natural astaxanthin, which composes up to 4-7% of its total dry weight. The bioaccumulation of astaxanthin in <i>H. pluvialis</i> cysts seems to be a very complex process that depends on different stress conditions during its cultivation. The red cysts of <i>H. pluvialis</i> develop thick and rigid cell walls under stress growing conditions. Thus, the biomolecule extraction requires general cell disruption technologies to reach a high recovery rate. This short review provides an analysis of the different steps in <i>H. pluvialis's</i> up and downstream processing including cultivation and harvesting of biomass, cell disruption, extraction and purification techniques. Useful information on the structure of <i>H. pluvialis's</i> cells, biomolecular composition and properties and the bioactivity of astaxanthin is collected. Special emphasis is given to the recent progress in application of different electrotechnologies during the growth stages and for assistance of the recovery of different biomolecules from <i>H. pluvialis</i>.
The applicability of special subject groups for assessing passenger reaction to flight environments (1973)

The following conclusions were reached on passenger responses: (1) Within acceptable limits, the crew/flight attendants do not appear to be able to predict passenger responses. (2) There exists a relationship between passenger and subject overall responses. (3) Finally, a strong relationship exists between a suitably weighted running and overall subjective response. The recommended weighting function W(I) is approximately equal to I to the 0.75 power, indicating that the latter part of a flight is given more importance in a subject's overall comfort evaluation than the beginning of the flight.
Bromocriptine response in normoprolactinemic patients with polycystic ovary disease: a preliminary report. (1984)

Recent work has suggested that a central deficiency or defect of dopamine may contribute significantly to the inappropriate gonadotropin secretion commonly associated with polycystic ovary disease. To evaluate this hypothesis, 2.5 to 5 mg of the dopamine agonist bromocriptine was administered daily to patients with polycystic ovary disease. Prolactin (PRL) levels were normal in all cases and there was no evidence of galactorrhea. All patients had failed to conceive while on clomiphene citrate. Seven patients were treated for a total of nine cycles. Ovulation occurred in four cycles, and two of these patients conceived. In five cycles, no ovulation occurred. Among ovulatory cycles, PRL levels declined, but not to undetectable levels. There was also a periovulatory drop in dehydroepiandrosterone sulfate. Levels of luteinizing hormones rose initially and then dropped to below baseline postovulation. Among anovulatory cycles, PRL fell to undetectable levels and dehydroepiandrosterone sulfate was unaffected. Luteinizing hormone levels rose initially and then dropped slightly. In both ovulatory and anovulatory cycles, follicle-stimulating hormone (FSH) levels remained low. These preliminary data suggest: 1) bromocriptine appears capable of altering gonadotropin secretion in polycystic ovary disease, and 2) variable results on ovulation in polycystic ovary disease may reflect the diverse etiology of the pathophysiology of polycystic ovary disease and/or choosing inappropriate dosages of bromocriptine.
Novel bandwidth- and center-wavelength-tunable interleaver (2005)

A novel bandwidth- and center-wavelength-tunable interleaver structure based on birefringent materials is proposed. This device can provide network designers more flexibility in their design work and reduce system upgrading and modification costs. Since the proposed structure is a kind of finite-impulse-response filter, the interleaver can be designed to be dispersion-free. Moreover, it can be implemented without moving parts to increase reliability. These two features make the proposed device attractive for increasing design flexibility and network efficiency. Simulation and experimental results are presented to verify the fundamental idea.
ENFIRE: A Spatio-Temporal Fine-Grained Reconfigurable Hardware (2016)

Field programmable gate arrays (FPGAs) are well-established as fine-grained reconfigurable computing platforms. However, FPGAs demonstrate poor scalability in advanced technology nodes due to the large negative impact of the elaborate programmable interconnects (PIs). The need for such vast PIs arises from two key factors: 1) fine-grained bit-level data manipulation in the configurable logic blocks and 2) the purely spatial computing model followed in the FPGAs. In this paper, we propose ENFIRE, a novel memory-based spatio-temporal framework designed to provide the flexibility of reconfigurable bit-level information processing while improving scalability and energy efficiency. Dense 2-D memory arrays serve as the main computing elements storing not only the data to be processed but also the functional behavior of the application mapped into lookup tables. Computing elements are spatially distributed, communicating as needed over a hierarchical bus interconnect, while the functions are evaluated temporally inside each computing element. A custom software framework facilitates application mapping to the framework. By leveraging both spatial and temporal computing, ENFIRE significantly reduces the interconnect overhead when compared with FPGA. Simulation results show an improvement of 7.6× in energy, 1.6× in energy efficiency, 1.1× in leakage, and 5.3× in unified energy efficiency, a metric that considers energy and area together, compared with comparable FPGA implementations.
Miniaturized and Reconfigurable Notch Antennas Using a BST Thin Film Varactor (2013)

Abstract — Ferroelectric (FE) thin film varactor technology can be used for antenna miniaturization and reconfiguration. We present more particularly a quarter wavelength notch antenna with a Barium Strontium Titanate (Ba (1-x)Sr xTiO 3, BST) thin film in MIM geometry. Integration of the BST varactor yields a size reduction of approximately 56 % with respect to the initial antenna size (0.064 × λ 0 without BST layer) and the miniaturized antenna is tunable from 0.94 GHz to 1.07 GHz. hal-00749723, version 1- 8 Nov 2012 I.