gebhart/patrepeval huggingface dataset:
Improved Catalyst Systems for SULEV Legislation: First Practical Experience (2000)

&lt;div class="htmlview paragraph"&gt;In order to achieve SULEV emission legislation the overall efficiency of the exhaust gas aftertreatment system has to be increased. Beside engine-out emissions and air/fuel ratio control especially during cold start and during transient driving conditions the catalyst has to be optimized regarding cold start and efficiency under warmed-up conditions. The paper will show emission test results of different catalyst designs (various cell-densities and foil thicknesses, cone-shape catalysts and electrically heated catalysts) measured on a dynamic engine test bench. With an optimized SULEV catalyst system emission tests in a close-coupled position of a mid-size passenger car will be presented.&lt;/div&gt;
Thermal electrocyclic ring closure of alkenylhexa-1,3,5-trienes and the question of anchimeric π-bond participation (1979)

The anomalously fast electrocyclic ring closure of 3-vinylhexa-1,3,5-triene to yield 2-vinylcyclohexa-1,3-diene had previously been interpreted as involving anchimeric π-bond participation of the 3-vinyl group in the electrocyclization transition state. In order to determine whether this observation and interpretation was indeed characteristic of alkenyl side-chains, 3-allylhexa-1,3,5-triene and 3-propylhexa-1,3,5-trienes were synthesized and their electrocyclization rates and activation parameters compared both to each other and to the corresponding 3-ethyl and 3-vinyl trienes. The results conclusively show that the accelerative effect operative in 3-vinylhexa-1,3,5-triene ring closure does not extend to non-conjugated alkenyl side chains.
Phase Behaviour, Interactions, and Structural Studies of (Amines+Ionic Liquids) Binary Mixtures (2012)

We present a study on the phase equilibrium behaviour of binary mixtures containing two 1-alkyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide-based ionic liquids, [C(n)mim] [NTf(2)] (n=2 and 4), mixed with diethylamine or triethylamine as a function of temperature and composition using different experimental techniques. Based on this work, two systems showing an LCST and one system with a possible hourglass shape are measured. Their phase behaviours are then correlated and predicted by using Flory-Huggins equations and the UNIQUAC method implemented in Aspen. The potential of the COSMO-RS methodology to predict the phase equilibria was also tested for the binary systems studied. However, this methodology is unable to predict the trends obtained experimentally, limiting its use for systems involving amines in ionic liquids. The liquid-state structure of the binary mixture ([C(2)mim] [NTf(2)]+diethylamine) is also investigated by molecular dynamics simulation and neutron diffraction. Finally, the absorption of gaseous ethane by the ([C(2)mim][NTf(2)]+diethylamine) binary mixture is determined and compared with that observed in the pure solvents.
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-a/b and for signal transduction (1995)

International audience
Why Having 10,000 Parameters in Your Camera Model is Better Than Twelve (2019)

Camera calibration is an essential first step in setting up 3D Computer Vision systems. Commonly used parametric camera models are limited to a few degrees of freedom and thus often do not optimally fit to complex real lens distortion. In contrast, generic camera models allow for very accurate calibration due to their flexibility. Despite this, they have seen little use in practice. In this paper, we argue that this should change. We propose a calibration pipeline for generic models that is fully automated, easy to use, and can act as a drop-in replacement for parametric calibration, with a focus on accuracy. We compare our results to parametric calibrations. Considering stereo depth estimation and camera pose estimation as examples, we show that the calibration error acts as a bias on the results. We thus argue that in contrast to current common practice, generic models should be preferred over parametric ones whenever possible. To facilitate this, we released our calibration pipeline at https://github.com/puzzlepaint/camera_calibration, making both easy-to-use and accurate camera calibration available to everyone.
The effect of gate drive topology on online silicon carbide MOSFET junction temperature sensing (2015)

The switching transient properties of conventional power semiconductors (Silicon MOSFET and IGBT) have been proposed for online junction temperature (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> ) sensing. This method utilizes the semiconductor T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> dependent characteristics and the gate drive output dynamics. In this paper, the method is applied to wide bandgap power semiconductor, Silicon-Carbide (SiC) MOSFET. In order to demonstrate the SiC MOSFET T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> sensing, de-capsulated SiC MOSFETs are implemented in an H-bridge. The SiC MOSFETs are driven by voltage source-based gate drive (VSG) and current source-based gate drive (CSG). The effect of using different gate drive topologies for this T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">j</sub> sensing method is compared based on different “gate drive - semiconductor” switching dynamic models. The “gate drive - semiconductor” dynamic model includes gate drive output stage, gate drive parasitics, SiC MOSFET intrinsic parameters, PCB parasitics, and a resistive load. Experimental results are compared with circuit LTSpice model simulation.
Alignment of D2(v, J) desorbed from Cu(111): Low sensitivity of activated dissociative chemisorption to approach geometry (1996)

We have determined the alignment of D2(v,J) desorbed from Cu(111). The measurements reveal a small preference for ‘‘helicoptering’’ motion that increases with increasing J. At low J, the alignments are much smaller than predicted by recent calculations. We believe that the anisotropic potential may scramble the alignment as the molecules leave the surface.
A Conserved Hydrophobic Moiety and Helix–Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4 (2021)

Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix-helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers.
New Monoclonal Antibody Diagnostic Reagents for Type I Diabetes: Differential Lymphocyte Surface Antigen Expression Related to Disease (1997)

New cellular-based reagents are needed to diagnose type I diabetes as well as to monitor the outcomes of clinical trials at early time points. Four new monoclonal antibodies (mAbs) have been shown to demonstrate reduced binding to lymphocytes from identical twins with long-term type I diabetes relative to that observed with lymphocytes from their twin partners without diabetes or from control subjects. Biochemical analysis revealed mAb 3G12EG recognized an unidentified 45-kDa protein, whereas mAb 2E8F1 and 5B6E11 did not appear to precipitate specific proteins as detected by SDS-PAGE. Electrophoresis under reducing and nonreducing conditions and peptide mapping revealed that mAb 8F410 recognizes a novel dimeric form of HLA class I molecule. Predictions from crystallography studies suggested previously this class I dimer as the optimal activation of a single CD8 T-cell. In B-cells from both normal and diabetic individuals, the class I dimer was minimally associated with beta2-microglobulin rapidly formed in the endoplasmic reticulum. These new reagents appear to be able to identify new lymphocyte surface phenotypes associated with diabetes expression in both fresh blood samples and Epstein-Barr virus-established cell lines.
The Ubiquitous Camera: An In-Depth Study of Camera Phone Use (2005)

Little in-depth data exists regarding what users actually do with their camera phones. Our goal was thus to understand how people use camera phone images for social and personal purposes and affective and functional purposes. We had two main objectives. The first was to explore the range and diversity of use to help broaden our outlook on current and future camera phone use. The second was to elucidate the characteristics and context of use for different activities to learn how we might better support such activities.
Draft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a (2015)

Here, we report the draft genome sequence of Streptomyces sp. TP-A0890, a producer of FR-900452 and A-74863a. The genome was found to contain at least eight polyketide synthase and nonribosomal peptide synthetase gene clusters. A prediction of gene functions based on the sequence similarity allowed us to assign the biosynthetic gene clusters for FR-900452 and A-74863a.
Measurement of the Inelastic Proton-Proton Cross Section at with the ATLAS Detector at the LHC (2016)

This Letter presents a measurement of the inelastic proton-proton cross section using 60 μb−1 of pp&#13;\ncollisions at a center-of-mass energy ffiffi&#13;\ns p of 13 TeV with the ATLAS detector at the LHC. Inelastic&#13;\ninteractions are selected using rings of plastic scintillators in the forward region (2.07&lt;jηj&lt;3.86) of the&#13;\ndetector. A cross section of 68.1 1.4 mb is measured in the fiducial region ξ¼M2&#13;\nX=s&gt;10−6, where MX is&#13;\nthe larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event.&#13;\nIn this ξ range the scintillators are highly efficient. For diffractive events this corresponds to cases where at&#13;\nleast one proton dissociates to a system with MX &gt;13GeV. The measured cross section is compared with a&#13;\nrange of theoretical predictions. When extrapolated to the full phase space, a cross section of 78.1 2.9 mb&#13;\nis measured, consistent with the inelastic cross section increasing with center-of-mass energy.&#13;\n
Random Access Identifier-Linked Receiver Beamforming with Transmitter Filtering in TDD-Based Random Access (2022)

This paper proposes a novel random access identifier (RAID)-linked receiver beamforming method for time division duplex (TDD)-based random access. When the number of receiver antennas at the base station is large in a massive multiple-input multiple-output (MIMO) scenario, the channel estimation accuracy per receiver antenna at the base station receiver is degraded due to the limited received signal power per antenna from the user terminal. This results in degradation in the receiver beamforming (BF) or antenna diversity combining and active RAID detection. The purpose of the proposed method is to achieve accurate active RAID detection and channel estimation with a reasonable level of computational complexity at the base station receiver. In the proposed method, a unique receiver BF vector applied at the base station is linked to each of the M RAIDs prepared by the system. The user terminal selects an appropriate pair comprising a receiver BF vector and a RAID in advance based on the channel estimation results in the downlink assuming channel reciprocity in a TDD system. Therefore, per-receiver antenna channel estimation for receiver BF is not necessary in the proposed method. Furthermore, in order to utilize fully the knowledge of the channel at the user transmitter, we propose applying transmitter filtering (TF) to the proposed method for effective channel shortening in order to increase the orthogonal preambles for active RAID detection and channel estimation prepared for each RAID. Computer simulation results show that the proposed method greatly improves the accuracy of active RAID detection and channel estimation. This results in lower error rates than that for the conventional method performing channel estimation at each antenna in a massive MIMO environment.
Second-line, post-docetaxel therapy for advanced, androgen deprivation-refractory prostate cancer (2012)

Reason for Withdrawal


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Development of a Physical Simulator Model for Developing and Evaluating Endoscopic Endonasal Surgical Skills (2014)

Introduction: Endoscopic endonasal surgical approaches are becoming an important option in skull base surgery, but require the development of a unique skill set in the context of a team approach. There is a need for developing and evaluating endoscopic endonasal surgical skills outside of the operating room for training purposes and for proficiency assessment as has been done in other surgical disciplines. In this study, we test the ability of five simulated surgical tasks to discriminate between surgeons based on skill level and also investigate surgeon perceptions of workload and validity.
A Pay-As-You-Go Methodology for Ontology-Based Data Access (2017)

A successfully repeated use case for Semantic Web technologies is Ontology-Based Data Access for data integration. In this approach, an ontology serves as a uniform conceptual federating model, which is accessible to both IT developers and business users. Here, two challenges for developing an OBDA system are considered: ontology and mapping engineering, along with a pay-as-you-go methodology that addresses these challenges and enables agility.
Abstract 5687: Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models (2020)

Abstract The mammalian SWI/SNF complex catalyzes the remodeling of chromatin through the helicase activity of two mutually-exclusive, paralogous subunits, BRG1 and BRM. BRG1 is frequently mutated in cancer and its inactivation results in a cellular dependence on BRM. Despite the attractiveness of BRM as a synthetic lethal therapeutic target, the selective inhibition of BRM represents a considerable challenge due to the high degree of homology between BRM and BRG1. Furthermore, published data indicate that achieving such selectivity is likely essential to afford an acceptable therapeutic index. We sought to mimic the synthetic lethality observed in BRG1-mutant cancers by identifying proteolysis-targeting chimera (PROTAC®) molecules capable of selectively degrading BRM via trimeric complex formation with the von Hippel-Lindau (VHL) E3 ligase. In this disclosure, we report our initial discovery of potent and selective chimeric BRM-degrader molecules which exhibit BRM DC50 values &amp;lt;1 nM and BRG1/BRM DC50 ratios &amp;gt;25. Importantly, selective BRM degradation can be achieved in the absence of selective PROTAC® binding (BRG1/BRM Kd ratios &amp;lt;2). Global ubiquitin mapping and proteome profiling reveal no unexpected off-target activity of the selective BRM PROTAC® degraders. Treatment of a panel of NSCLC cell lines with a representative degrader molecule resulted in enhanced growth inhibition in BRG1-mutant relative to BRG1-wild-type cell lines. We also demonstrate that intermittent intravenous administration of an optimized BRM PROTAC® degrader exhibited strong in vivo modulation of pharmacodynamic biomarkers and afforded tumor growth inhibition in several BRG1-mutant xenograft models. Our study thus highlights the ability to transform a non-selective BRM-binding ligand into a selective and efficacious in vivo BRM PROTAC® degrader. Citation Format: Michael Berlin, Jennifer Cantley, Jing Wang, Mark Bookbinder, Gregory Cadelina, Emily Chan, Huifen Chen, Xin Chen, Kim Davenport, Tharu Fernando, Debbie Gordon, Brian Hamman, Roy Haskell, Alexey Ishchenko, Donald S. Kirkpatrick, Jonathan Maher, Mark Merchant, John Moffat, Alicia Morgan, An Nguyen, Jennifer Pizzano, Connor Quinn, Christopher M. Rose, Emma Rousseau, Vijay Sethuraman, Leanna Staben, Catherine Wilson, Xiaofen Ye, Fabio Broccatelli, Robert Yauch, Peter S. Dragovich. Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5687.
Cognitive Dimensions of Information Artefacts: a tutorial (1998)

ion types and availability of abstraction mechanisms Hidden dependencies important links between entities are not visible Premature commitment constraints on the order of doing things Secondary notation extra information in means other than formal syntax Viscosity resistance to change Visibility ability to view components easily Dimensions not treated in this tutorial Closeness of mapping closeness of representation to domain Consistency similar semantics are expressed in similar syntactic forms Diffuseness verbosity of language Error-proneness notation invites mistakes Hard mental operations high demand on cognitive resources Progressive evaluation work-to-date can be checked at any time Provisionality degree of commitment to actions or marks Role-expressiveness the purpose of a component is readily inferred
Flexible Low-Cost System for Small Animal Aerosol Inhalation Exposure to Drugs, Proteins, Inflammatory Agents, and Infectious Agents (2009)

The design for a simple, low-cost aerosol generation system for rodent inhalation studies is described here. This system is appropriate for low biohazard-level agents. In this study, two biosafety level 2 agents, Pasturella pneumotropica and Pseudomonas aeruginosa, were tested successfully. This system was also used to immunize mice and guinea pigs in ovalbumin-based models of pulmonary inflammation. This design is appropriate for studies with limited budgets and lower-level biosafety containment.
A 2×2 MIMO baseband for high-throughput wireless local-area networking (802.11n) (2007)

This article consists of a collection of slides from the author's conference presentation on a 2X2 MIMO basedband system for high throughput wireless local area networking. Some of the specific topics discussed include: the demand for wireless LAN, 2000-2011; schemas of multipath channels; exploiting multipath processing for high rates and the impact on energy capacity planning; system architecture for MIMO-ODFM; system processing capabilities and performance summaries; the need for flexible transceivers; and block diagrams and system topologies.
Ligand binding and structural rearrangements of quadruplexes containing human telomeric sequences (2008)

We have obtained pre-catalytic (enzyme-substrate complex) and post-catalytic (enzyme-product complex) crystal structures of an active full-length hammerhead ribozyme that cleaves in the crystal. Using the natural satellite tobacco ringspot virus (sTRSV) hammerhead RNA sequence, the self-cleavage reaction was modulated by substituting the general base of the ribozyme, G12, with A12, a purine variant with a much lower pKa that does not significantly perturb the ribozyme's atomic structure. The active but slowly cleaving ribozyme thus permits isolation of enzyme-substrate and enzymeproduct complexes without modifying the nucleophile or leaving group of the cleavage reaction, nor any other aspect of the substrate. The pre-dissociation enzyme-product complex structure reveals RNA and metal ion interactions potentially relevant to transition-state stabilization that are absent in pre-catalytic structures.
Large‐vocabulary spontaneous speech recognition using a corpus of lectures (2003)

Abstract Now that dictation systems have become a reality, research on large‐vocabulary voice recognition is shifting from “read speech” to “spontaneous speech.” The features of this kind of spontaneous speech have been investigated from various perspectives using a corpus of dialog speech. However, in particular for the Japanese language, creating a voice recognition system which has massive amounts of data and is based on statistical methods is not necessarily sufficient. There have been few reports on the performance of a large‐vocabulary voice recognition system whose purpose is tagging spontaneous speech. The authors have prepared a spontaneous speech corpus using as materials lecture speeches from the University of the Air for the purpose of improving the recognition precision for spontaneous speech. They report here on the recognition performance of their large‐vocabulary spontaneous speech recognition system created using this corpus. The results of experiments showed that the word error rate for lecture speeches, which was 51.5% under conventional systems that use reading, was reduced to 16.4%. © 2003 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 86(8): 52–60, 2003; Published online in Wiley InterScience ( www. interscience.wiley.com ). DOI 10.1002/ecjc.10105
A new heuristic UTD diffraction coefficient for prediction of radio wave propagation (2004)

In this paper, a new heuristic diffraction coefficient is proposed for dielectric wedges with losses. The suggested diffraction coefficient is based on the uniform theory of diffraction (UTD) and is compared to Luebbers', Holm's and the rigorous diffraction coefficient (RDC). Parallel and perpendicular field polarizations are tested. The new heuristic diffraction coefficient shows clear accuracy improvement over Luebbers' and Holm's coefficients when compared to the RDC. Moreover, the proposed diffraction coefficient is as simple to compute as Luebbers' and Holm's coefficients.
A Matrix Version of the Fast Multipole Method (2001)

We present a matrix interpretation of the three-dimensional fast multipole method (FMM). The FMM is for efficient computation of gravitational/electrostatic potentials and fields. It has found various applications and inspired the design of many efficient algorithms. The one-dimensional FMM is well interpreted in terms of matrix computations. The three-dimensional matrix version reveals the underlying matrix structures and computational techniques used in FMM. It also provides a unified view of algorithm variants as well as existing and emerging implementations of the FMM.