gebhart/patrepeval huggingface dataset:
<title>Half-wave cavity vertical-cavity surface-emitting lasers with native oxide/GaAs lower distributed Bragg reflectors</title> (1997)

Data are presented on half-wave cavity vertical cavity surface emitting lasers using both oxide confinement and high contrast upper and lower distributed Bragg reflectors. Six pairs of MgF/ZnSe distributed Bragg reflectors make up the top mirror and 11 pairs of Al<SUB>x</SUB>O<SUB>y</SUB>/GaAs DBRs make up the lower DBR. The oxide layer thickness in the Al<SUB>x</SUB>O<SUB>y</SUB>/GaAs DBRs is less than a quarter-wavelength in order to reduce strain on the quantum well active region. The lasing characteristics of device sizes ranging from 7 micrometer to 1 micrometer are analyzed through spectral data, far field radiation patterns and lasing threshold.
Expression of intracellular fibrinogen on the surface of stimulated platelets (1986)

Participation of fibrinogen in platelet aggregation is contingent upon the capacity of various stimuli to induce specific receptors for the molecule on the surface of the cell. The interaction of fibrinogen with this receptor results directly in platelet aggregation, and dissociation of fibrinogen is associated with disaggregation. While the role of exogenous fibrinogen in this process has been fully documented, the mechanisms which control the surface exposure of platelet fibrinogen are less understood. In the present study Fab fragments of antibodies monospecific for fibrinogen have been used to examine the surface expression of intracellular fibrinogen and its involvement in platelet aggregation. Radiolabelled Fab fragments did not interact with non-stimulated platelets but significant binding was observed when the cells were stimulated by ADP, thrombin, collagen and Ca ionophore A23187. Binding was specific for fibrinogen, was not observed with thrombasthenic platelets and was dependent upon the presence of extracellular calcium. With all stimuli tested, the binding of the Fab probe to platelets correlated with platelet secretion. At the following concentrations of stimuli: 30 microM ADP, 4 micrograms/ml collagen, 3 microM A23187 and 0.05 U/ml thrombin, the immune Fab fragments inhibited platelet aggregation. A monoclonal antibody to glycoprotein IIb/IIIa complex and a synthetic peptide gamma 400-411, that inhibited the interaction of plasma fibrinogen with platelets, did not inhibit the binding of 125I-FAB fragments. Taken together these results support the hypothesis that endogenous fibrinogen becomes surface-expressed during stimulation of the cell and can support platelet aggregation, particularly that induced by low concentrations of stimuli. The mechanism for the surface expression of platelet fibrinogen may be distinct from that for the binding of plasma fibrinogen.
Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation (2001)

P-selectin-dependent leukocyte-endothelial cell adhesion has been implicated in the pathogenesis of ischemia/reperfusion (I/R) injury in several vascular beds, including the gut. Because platelet-endothelial (P/E) cell adhesion also occurs in postischemic venules, the possibility exists that the expression of P-selectin on the surface of platelets that are adherent to venular endothelial cells may mediate the leukocyte recruitment elicited by I/R. P-selectin expression [dual radiolabeled monoclonal antibody (MAb) technique] and neutrophil accumulation [myeloperoxidase (MPO) activity] were measured in the postischemic small intestine of untreated rats and rats treated with either antiplatelet serum (APS) or MAbs directed against either P-selectin, GPIIb/IIIa, or fibrinogen. The increases in P-selectin expression and tissue MPO normally elicited by I/R were significantly attenuated in the different treatment groups, suggesting that I/R-induced neutrophil recruitment is a platelet-dependent, P-selectin-mediated process. Intravital microscopy was then employed to examine this process relative to leukocyte-endothelial cell adhesion in postischemic rat mesenteric venules. The recruitment of adherent and emigrated leukocytes after I/R was attenuated by pretreatment with a MAb against, either P-selectin, GPIIb/IIIa, or fibrinogen, as well as an Arg-Gly-Asp peptide. Whereas thrombocytopenia greatly blunted leukocyte emigration, it did not alter the leukocyte adherence response to I/R. These findings suggest that platelet-associated P-selectin contributes to the accumulation of leukocytes in postischemic tissue via a mechanism that alters transendothelial leukocyte migration.
Violin acoustic radiation synthesis: A source model for direct sound enhancement in musical acoustic environments (2004)

Within the context of immersive acoustic environments (real or virtual) for purposes of musical performance, it is useful to recreate the acoustic field radiated by real musical instruments. Given the popularity of wave field synthesis for direct sound enhancement and other methods of holophonic sound imaging, source modeling is a desirable development for such musical applications. There exist careful directivity measurements of the sound radiation of the violin in the frequency range from 1 to 5 kHz, over which the far field directivity changes rapidly as a function of frequency [L. M. Wang, ‘‘Radiation Mechanisms from Bowed Violins,’’ Ph.D. thesis, Pennsylvania State University, 1999]. Source models based on these measurements using a cylindrical harmonic decomposition are presented. With this preliminary approach to violin acoustic radiation modeling, issues regarding further auralization of this synthesized field are subsequently addressed.
Calculation of joint reaction force and joint moments using by wearable walking analysis system (2012)

In gait analysis, which is one useful method for efficient physical rehabilitation, the ground reaction force, the center of pressure, and the body orientation data are measured during walking. In the past, these data were measured by a 3D motion analysis system consisting of high-speed cameras and force plates, which must be installed in the floor. However, a conventional 3D motion analysis system can measure the ground reaction force and the center of pressure just on force plates during a few steps. In addition, the subjects' stride lengths are limited because they have to walk on the center of the force plate. These problems can be resolved by converting conventional devices into wearable devices. We used a measuring device consisting of portable force plates and motion sensors. We developed a walking analysis system that calculates the ground reaction force, the center of pressure, and the body orientations and measured a walking subject to estimate this system. We simultaneously used a conventional 3D motion analysis system to compare with our development system and showed its validity for measurements of ground reaction force and the center of pressure. Moreover we calculated joint reactions and joint moment of each joint.
A Scalable Neural Shortlisting-Reranking Approach for Large-Scale Domain Classification in Natural Language Understanding (2018)

Intelligent personal digital assistants (IPDAs), a popular real-life application with spoken language understanding capabilities, can cover potentially thousands of overlapping domains for natural language understanding, and the task of finding the best domain to handle an utterance becomes a challenging problem on a large scale. In this paper, we propose a set of efficient and scalable neural shortlisting-reranking models for large-scale domain classification in IPDAs. The shortlisting stage focuses on efficiently trimming all domains down to a list of k-best candidate domains, and the reranking stage performs a list-wise reranking of the initial k-best domains with additional contextual information. We show the effectiveness of our approach with extensive experiments on 1,500 IPDA domains.
Differential Expression of Type I MAGE in New and Relapsed Multiple Myeloma: Evidence for Association with Proliferation and Progression of Disease. (2006)

Abstract The type I Melanoma Antigen GEne (MAGE) proteins belong to the Cancer-Testis family of tumor-associated antigens and are found in a broad range of solid and hematologic malignancies. We previously showed that the type I MAGE proteins CT7 (MAGE-C1) and MAGE-A3 were commonly detected in primary myeloma by both RT-PCR and immunohistochemistry (IHC). Higher levels of MAGE protein expression had a positive correlation with abnormally elevated proliferation as measured by the Plasma Cell Proliferation Index (PCPI, percentage of Ki-67+ cells in the CD138+ myeloma cell compartment). These findings suggest that MAGE may play a role in abnormal cell cycle regulation in myeloma. We explored this hypothesis by examining type I MAGE gene expression and proliferation by IHC in 46 newly-diagnosed, untreated and 35 relapsed myeloma patients, based on the clinical observation that relapsed patients exhibit lower response rates to therapy and shorter time to progression, indicative of more aggressive disease. PCPI was significantly higher in relapsed patients (19.0 ± 3.5%) compared to newly diagnosed (6.9 ± 1.3%, p&lt;0.0002). Expression of CT7 and CT10 (MAGE-C2), a type I MAGE not previously associated with myeloma, was stable between newly-diagnosed and relapsed patients (76.0% of new samples vs. 77.1% of relapsed for CT7, 48.5% vs. 50.0% for CT10). In contrast, MAGE-A3 was detected in a significantly greater percentage of relapsed patients (77.1%) compared to newly diagnosed (35.6%, p=0.0003). The link between MAGE expression and unrestricted proliferation was further supported by in vitro studies with human myeloma cell lines. Proliferating myeloma cells were metabolically labeled with the nucleotide analog bromodeoxyuridine (BrdU) followed by intracellular staining and flow cytometry. This assay demonstrated that proliferating myeloma cells that incorporated BrdU into their genomic DNA expressed higher levels of type I MAGE protein compared to non-proliferating cells. Arresting cells at the G1-S interface by double thymidine blockade lead to the accumulation of cells expressing high levels of MAGE, which rapidly entered S phase and incorporated BrdU upon release from block. These results strongly suggest that expression of CT7 and CT10 are relatively early and stable events in the pathogenesis of myeloma, whereas activation of MAGE-A3 expression is associated with disease progression. Furthermore, MAGE expression is correlated with abnormal proliferation in vitro and in vivo, suggesting a potential functional role in the dysregulation of the cell cycle that is a hallmark of this disease. These results support the further exploration of the role of type I MAGE expression in myeloma and the development of therapeutic agents targeting them, especially tumor vaccines.
Convolutional coding schemes for variable rate, unequal error protection, and packet data services (1998)

Flexible and low-complexity variable rate coding schemes based on rate-compatible convolutional codes are presented. The codes have a wide range of code rates and are optimized for good performance on both AWGN and Rayleigh fading channels. Furthermore, the application of these codes for rate matching, combined coding and spreading in a DS-CDMA system and hybrid type-II ARQ schemes are demonstrated. Very long constraint length convolutional codes with sequential decoding is proposed and shown to be suitable for high performance services in wireless systems. 1 Introduction Since the introduction of cellular telephony in the early 80&amp;apos;s, virtually all markets and operators have seen a rapid increase in the number of subscribers. In the early 90&amp;apos;s the first generation analog systems were replaced by the second generation digital systems. These systems have higher capacity due to source (speech) coding, channel coding and the inherent robustness of digital transmission. Common for all thes...
Effect of hydropriming on seed germination parameters in different accessions ofWithania somnifera (2016)

Withania somnifera, commonly known as ashwagandha, is a commercially cultivated medicinal plant species having a consistent demand in pharmaceutical industries. Although propagated through seeds, there is always a scope for enhancement of seed germination capacity either through selection of accessions that have natural high seed germination rate or through some physiological interventions. We have examined the influence of hydropriming treatment on seed germination parameters that have revealed a positive correlation between hydropriming and higher germination rates.
Evaluation of lattice curvature and crystalline homogeneity for 2-inch GaN homo-epitaxial layer (2018)

We evaluated the lattice curvature, crystallinity, and crystalline homogeneity of a GaN layer on a free standing GaN substrate using lattice orientation measurements, θ rocking curves, and reciprocal space mapping from synchrotron X-ray diffraction topography, and X-ray diffraction. The lattice curvature of the 2-inch GaN homo-epitaxial layer was a concave bend, which had a curvature radius of approximately 20.7 m. The GaN layer was epitaxially grown on the GaN substrate and had good crystallinity with a high homogeneity.
Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor (2003)

Blood coagulation is triggered by the formation of a complex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF). TF-FVIIa is inhibited by tissue factor pathway inhibitor (TFPI) in two steps: first TFPI is bound to the active site of factor Xa (FXa), and subsequently FXa-TFPI exerts feedback inhibition of TF-FVIIa. The FXa-dependent inhibition of TF-FVIIa activity by TFPI leads to formation of the quaternary complex TF-FVIIa-FXa-TFPI. We used site-directed fluorescence probing to map part of the region of soluble TF (sTF) that interacts with FXa in sTF-FVIIa-FXa-TFPI. We found that the C-terminal region of sTF, including positions 163, 166, 200 and 201, is involved in binding to FXa in the complex, and FXa, most likely via its Gla domain, is also in contact with the Gla domain of FVIIa in this part of the binding region. Furthermore, a region that includes the N-terminal part of the TF2 domain and the C-terminal part of the TF1 domain, i.e. the residues 104 and 197, participates in the interaction with FXa in the quaternary complex. Moreover, comparisons of the interaction areas between sTF and FX(a) in the quaternary complex sTF-FVIIa-FXa-TFPI and in the ternary complexes sTF-FVII-FXa or sTF-FVIIa-FX demonstrated large similarities.
The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1 (2003)

Evolutionary links between cytochrome P450 monooxygenases, a superfamily of extraordinarily divergent heme-thiolate proteins catalyzing a wide array of NADPH/NADH- and O(2)-dependent reactions, are becoming better understood because of availability of an increasing number of fully sequenced genomes. Among other reactions, P450s catalyze the site-specific oxidation of the precursors to macrolide antibiotics in the genus Streptomyces introducing regiochemical diversity into the macrolide ring system, thereby significantly increasing antibiotic activity. Developing effective uses for Streptomyces enzymes in biosynthetic processes and bioremediation requires identification and engineering of additional monooxygenases with activities toward a diverse array of small molecules. To elucidate the molecular basis for substrate specificity of oxidative enzymes toward macrolide antibiotics, the x-ray structure of CYP154C1 from Streptomyces coelicolor A3(2) was determined (Protein Data Bank code ). Relocation of certain common P450 secondary structure elements, along with a novel structural feature involving an additional beta-strand transforming the five-stranded beta-sheet into a six-stranded variant, creates an open cleft-shaped substrate-binding site between the two P450 domains. High sequence similarity to macrolide monooxygenases from other microbial species translates into catalytic activity of CYP154C1 toward both 12- and 14-membered ring macrolactones in vitro.
MBE Growth of Thick InGaAsN Layers Lattice-Matched to InP Substrates (2007)

We investigated the effects of growth temperature and As/III flux ratio on thick InGaAsN layers lattice-matched to InP substrates. We found that surface morphology and crystalline quality can be improved by growing at temperature higher than 480&3x000B0;C. By optimizing the As/III flux ratio, we successfully obtained the InGaAsN layer with PL wavelength as long as 2.03μm at room temperature.
Hydrazine Detectors Based On Raman Scattering (1992)

Goal of sensor-development program to measure concentrations as low as few parts per billion in continuous monitoring as well as peak concentrations up to hundreds of parts per million, such as encountered near leaks. Sensors based on Raman scattering from hydrazine or monomethyl hydrazine adsorbed on roughened metal or metal oxide substrates. Similar systems developed to detect nitrogen oxides and other gases.
Scaling Database Languages to Higher-Order Distributed Programming (1995)

We describe the Tycoon 1 approach to scale the successful notion of a uniform, type-safe persistent object store to communication-intensive applications and applications where long-term activities are allowed to span multiple autonomous network sites. Exploiting stream-based data, code and thread exchange primitives we present several distributed programming idioms in Tycoon. These programming patterns range from client-server communication basedon polymorphic higher-order remote procedure calls tomigrating autonomous agents that are bounddynamically to network resources present at individual network nodes. Following Tycoon’s add-on approach, these idioms are not cast into built-in syntactic forms, but are expressed by characteristic programming patterns exploiting communication primitives encapsulated by library functions. Moreover, we present a novel form of binding support for ubiquitous resources which drastically reduces communication traffic for modular distributed applications.
Gate recessing of GaN MESFETs using photoelectrochemicalwet etching (1999)

For the first time GaN-based MESFETs which have been recessed using a wet etching process are presented. Photoelectrochemical etching was used to recess openings through the heavily-doped n-GaN cap and into the n-GaN channel. The DC and RF characteristics of recessed-gate GaN MESFETs are presented.
Air-Accelerated Enantioselective Hydrosilylation of Ketones Catalyzed by Copper(I) Fluoride-Diphosphine Complexes: Investigations of the Effects of Temperature and Ligand Structure (2007)

The fluorotris(triphenylphosphine)copper(I)-bis(methanol) complex-chiral diphosphine system catalyzes the hydrosilylation of several alkyl aryl ketones with moderate to excellent enantioselectivity. An oxygen acceleration effect was observed and led to a practical protocol with low catalyst loading. Optimizations of enantioselectivities (&lt; 95%) and catalytic ratio (&lt; 0.05 mol%) were obtained with bulky Ar-MeO-BIPHEP ligands.
A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE). (2020)

116 Background: Mounting evidence supports metastatic ablation for oligometastatic prostate cancer (OMPC). Importantly, biomarkers to determine patients who benefit most from complete ablation are unknown. We hypothesize that stereotactic ablative radiation (SABR) will improve oncologic outcomes in men with OMPC. Methods: In this phase II randomized trial, men with recurrent hormone-sensitive OMPC (1-3 radiation fields) were stratified by primary management (radiotherapy vs surgery), PSA doubling time, and prior androgen deprivation therapy and randomized 2:1 to SABR or observation (OBS). The primary endpoint was progression at 6 months by PSA (≥ 25% increase and ≥ nadir + 2 ng/mL), conventional imaging (RECIST 1.1 criteria or new lesion on bone scan), or symptomatic decline. Tissue, liquid and imaging correlatives were analyzed as biomarkers. Results: From 5/2016-3/2018, 54 patients were randomized. Progression at six months occurred in 19% of SABR patients and 61% of observation patients [p=0.005]. SABR improved median PFS (not reached vs 5.8 months, HR 0.30, p = 0.0023). Total consolidation of PSMA radiotracer-avid disease decreased the risk of new lesions at six months (16% vs 63%, p = 0.006). No toxicity ≥ grade 3 was observed. T-cell receptor sequencing identified increased clonotypic expansion (p = 0.03) following SABR and correlation between baseline clonality and progression with SABR only. Analysis of circulating tumor DNA (ctDNA) and germline mutations identified a mutation profile that was associated with benefit from SABR. Conclusions: SABR for OMPC improves outcomes and is enhanced by total consolidation of disease identified by PSMA-targeted PET. SABR induces a systemic immune response, and baseline immune phenotype and tumor mutation status may predict the benefit from SABR. These results underline the importance of prospective randomized investigation of the oligometastatic state with integrated imaging and biological correlates. Clinical trial information: NCT02680587.
Joint Development of a Package-Level Thermal Interface Material Test System (2009)

As the microelectronics industry continues to trend towards smaller, lighter, and higher power devices, thermal management is becoming more important than ever. Thermal interface materials (TIMs) play a crucial role in removing heat from both bare die and lidded packages. A serious challenge the industry has been facing is the lack of an agreed upon test standard that is specifically tailored for TIM thermal performance measurements between TIM suppliers and OEM customers. ASTM D 5470 is not necessarily the best gauge for TIMs in-application performance. Data generated by the OEM often differ from TIM supplier’s results, and thus can not be used confidently in thermal design. An OEM’s material selection can also prove to be unreliable when comparing data from different TIM suppliers. This paper presents a successful model that an OEM customer (Sun Microsystems) and a TIM supplier (LORD Corporation) have established for characterization of TIMs, and illustrates a package-level thermal test vehicle (TTV) setup for junction-to-sink thermal resistance measurements. Also presented are test results for several TIMs and repeatability of the test method. The effects of a few influencing factors, such as pressure load and TIM staging time, on the test results are also discussed.