gebhart/patrepeval huggingface dataset:
Effect of hydrostatic pressure on polystyrene diffusivity in toluene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of hydrostatic pressure on polystyrene diffusivity in tolueneBenny D. Freeman, David S. Soane, and Morton M. DennCite this: Macromolecules 1990, 23, 1, 245–251Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://doi.org/10.1021/ma00203a042RIGHTS & PERMISSIONSArticle Views84Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (853 KB) Get e-Alerts Get e-Alerts
Coherence decoupling (2004)

This paper explores a new technique called coherence decoupling , which breaks a traditional cache coherence protocol into two protocols: a Speculative Cache Lookup (SCL) protocol and a safe, backing coherence protocol. The SCL protocol produces a speculative load value, typically from an invalid cache line, permitting the processor to compute with incoherent data. In parallel, the coherence protocol obtains the necessary coherence permissions and the correct value. Eventually, the speculative use of the incoherent data can be verified against the coherent data. Thus, coherence decoupling can greatly reduce --- if not eliminate --- the effects of false sharing. Furthermore, coherence decoupling can also reduce latencies incurred by true sharing. SCL protocols reduce those latencies by speculatively writing updates into invalid lines, thereby increasing the accuracy of speculation, without complicating the simple, underlying coherence protocol that guarantees correctness.The performance benefits of coherence decoupling are evaluated using a full-system simulator and a mix of commercial and scientific benchmarks. Our results show that 40% to 90% of all coherence misses can be speculated correctly, and therefore their latencies partially or fully hidden. This capability results in performance improvements ranging from 3% to over 16%, in most cases where the latencies of coherence misses have an effect on performance.
Community-Based Telemonitoring for Hypertension Management: Practical Challenges and Potential Solutions (2011)

Older adults residing in rural areas often lack convenient, patient-centered, community-based approaches to facilitate receipt of routine care to manage common chronic conditions. Without adequate access to appropriate disease management resources, the risk of seniors' experiencing acute events related to these common conditions increases substantially. Further, poorly managed chronic conditions are costly and place seniors at increased risk of institutionalization and permanent loss of independence. Novel, telehealth-based approaches to management of common chronic conditions like hypertension may not only improve the health of older adults, but may also lead to substantial cost savings associated with acute care episodes and institutionalization. The aim of this report is to summarize practical considerations related to operations and logistics of a unique community-based telemonitoring pilot study targeting rural seniors who utilize community-based senior centers. This article reviews the technological challenges encountered during the study and proposes solutions relevant to future research and implementation of telehealth in community-based, congregate settings.
Finding twin smooth integers by solving Pell equations (2022)

Any pair of consecutive B-smooth integers for a given smoothness bound B corresponds to a solution (x, y) of the equation x^2 - 2Dy^2 = 1 for a certain square-free, B-smooth integer D and a B-smooth integer y. This paper describes algorithms to find such twin B-smooth integers that lie in a given interval by using the structure of solutions of the above Pell equation. The problem of finding such twin smooth integers is motivated by the quest for suitable parameters to efficiently instantiate recent isogeny-based cryptosystems. While the Pell equation structure of twin B-smooth integers has previously been used to describe and compute the full set of such pairs for very small values of B, increasing B to allow for cryptographically sized solutions makes this approach utterly infeasible. We start by revisiting the Pell solution structure of the set of twin smooth integers. Instead of using it to enumerate all twin smooth pairs, we focus on identifying only those that lie in a given interval. This restriction allows us to describe algorithms that navigate the vast set of Pell solutions in a more targeted way. Experiments run with these algorithms have provided examples of twin B-smooth pairs that are larger and have smaller smoothness bound B than previously reported pairs. Unfortunately, those examples do not yet provide better parameters for cryptography, but we hope that our methods can be generalized or used as subroutines in future work to achieve that goal.
Dynamic regulation of Drosophila nuclear receptor activity in vivo (2006)

Nuclear receptors are a large family of transcription factors that play major roles in development, metamorphosis, metabolism and disease. To determine how, where and when nuclear receptors are regulated by small chemical ligands and/or protein partners, we have used a 'ligand sensor' system to visualize spatial activity patterns for each of the 18 Drosophila nuclear receptors in live developing animals. Transgenic lines were established that express the ligand binding domain of each nuclear receptor fused to the DNA-binding domain of yeast GAL4. When combined with a GAL4-responsive reporter gene, the fusion proteins show tissue- and stage-specific patterns of activation. We show that these responses accurately reflect the presence of endogenous and exogenously added hormone, and that they can be modulated by nuclear receptor partner proteins. The amnioserosa, yolk, midgut and fat body, which play major roles in lipid storage, metabolism and developmental timing, were identified as frequent sites of nuclear receptor activity. We also see dynamic changes in activation that are indicative of sweeping changes in ligand and/or co-factor production. The screening of a small compound library using this system identified the angular psoralen angelicin and the insect growth regulator fenoxycarb as activators of the Ultraspiracle (USP) ligand-binding domain. These results demonstrate the utility of this system for the functional dissection of nuclear receptor pathways and for the development of new receptor agonists and antagonists that can be used to modulate metabolism and disease and to develop more effective means of insect control.
An efficient implementation of numerical integration using logical computation on stochastic bit streams (2012)

Numerical integration is a widely used approach for computing an approximate result of a definite integral. Conventional digital implementations of numerical integration using binary radix encoding are costly in terms of hardware and have long computational delay. This work proposes a novel method for performing numerical integration based on the paradigm of logical computation on stochastic bit streams. In this paradigm, ordinary digital circuits are employed but they operate on stochastic bit streams instead of deterministic values; the signal value is encoded by the probability of obtaining a one versus a zero in the streams. With this type of computation, complex arithmetic operations can be implemented with very simple circuitry. However, typically, such stochastic implementations have long computational delay, since long bit streams are required to encode precise values. This paper proposes a stochastic design for numerical integration characterized by both small area and short delay -- so, in contrast to previous applications, a win on both metrics. The design is based on mathematical analysis that demonstrates that the summation of a large number of terms in the numerical integration could lead to a significant delay reduction. An architecture is proposed for this task. Experiments confirm that the stochastic implementation has smaller area and shorter delay than conventional implementations.
[Periurethral collagen injections: results after 2 years in 25 patients with severe urinary incontinence]. (2001)

Due to its safety, this method can be proposed in outpatients with good results, in patients of all ages, either as first-line treatment or for recurrent incontinence, as, in the case of failure, this technique does not comprise subsequent treatment by another operation.
A Simple and Efficient Amplification Method of DNA with Unknown Sequences and Its Application to Microdissection/Microcloning1 (1992)

An alternative method for amplification of DNA with unknown sequences was developed. This involves the direct ligation of a primer oligodeoxyribonucleotide itself to restricted DNA fragments with unknown sequences to be amplified by PCR. The oligonucleotide need not be phosphorylated and need not be annealed with its complementary oligonucleotide in advance for ligation. The ligation reaction seems to be independent of the concentration of unknown DNA, proceeds in short time, and is efficient. The ligation efficiency was more than 30% at a low concentration, 10 fg/microliters, of DNA. This method was applied to a microdissection/microcloning of the short arm of human chromosome 2. Of 65 clones screened for the highly repetitive sequences with total human genomic DNA, eleven (17%) were positive. Their inserts ranged in size from 150 to 1,200 bp (average, 460 bp). In Southern blot analysis, thirty consecutive clones all detected signals common to both total human genomic DNA and mouse-human hybrid cell DNA containing only chromosome 2 of human origin. Among them, 24 (80%) were unique sequences, and 6 (20%) were multi-copy (or intermediate-repeat) sequences. Thus, this method is simple and efficient, and provides an alternative way to amplify unknown DNA.
Joint Contextual Modeling for ASR Correction and Language Understanding (2020)

The quality of automatic speech recognition (ASR) is critical to Dialogue Systems as ASR errors propagate to and directly impact downstream tasks such as language understanding (LU). In this paper, we propose multi-task neural approaches to perform contextual language correction on ASR outputs jointly with LU to improve the performance of both tasks simultaneously. To measure the effectiveness of this approach we used a public benchmark, the 2nd Dialogue State Tracking (DSTC2) corpus. As a baseline approach, we trained task-specific Statistical Language Models (SLM) and fine-tuned state-of-the-art Generalized Pre-training (GPT) Language Model to re-rank the n-best ASR hypotheses, followed by a model to identify the dialog act and slots. i) We further trained ranker models using GPT and Hierarchical CNN-RNN models with discriminatory losses to detect the best output given n-best hypotheses. We extended these ranker models to first select the best ASR output and then identify the dialogue act and slots in an end to end fashion. ii) We also proposed a novel joint ASR error correction and LU model, a word confusion pointer network (WCN-Ptr) with multi-head self-attention on top, which consumes the word confusions populated from the n-best. We show that the error rates of off the shelf ASR and following LU systems can be reduced significantly by 14% relative with joint models trained using small amounts of in-domain data.
Thermally Cross-Linkable Hole Transport Materials for Solution Processed Phosphorescent OLEDs (2018)

Materials for unique fabrication of a solution-processed, multi-layered organic light-emitting diode (OLED) were developed. Preparation of a hole transport layer with a thermally cross-linkable chemical structure, which can be processed to form a thin film and then transformed into an insoluble film by using an amine-alcohol condensation reaction with heat treatment, was investigated. Functional groups, such as triplenylamine linked with phenylcarbazole or biphenyl, were employed in the chemical structure of the hole transport layer in order to maintain high triplet energy properties. When phenylcarbazole or biphenyl compounds continuously react with triphenylamine under acid catalysis, a chemically stable thin film material with desirable energy-level properties for a blue OLED could be obtained. The prepared hole transport materials showed excellent surface roughness and thermal stability in comparison with the commercial reference material. On the solution-processed model hole transport layer, we fabricated a device with a blue phosphorescent OLED by using sequential vacuum deposition. The maximum external quantum, 19.3%, was improved by more than 40% over devices with the commercial reference material (11.4%).
Spatially Resolved Bottom‐Side Fluorination of Graphene by Two‐Dimensional Substrate Patterning (2020)

Abstract Patterned functionalization can, on the one hand, open the band gap of graphene and, on the other hand, program demanding designs on graphene. The functionalization technique is essential for graphene‐based nanoarchitectures. A new and highly efficient method was applied to obtain patterned functionalization on graphene by mild fluorination with spatially arranged AgF arrays on the structured substrate. Scanning Raman spectroscopy (SRS) and scanning electron microscopy coupled with energy‐dispersive X‐ray spectroscopy (SEM‐EDS) were used to characterize the functionalized materials. For the first time, chemical patterning on the bottom side of graphene was realized. The chemical nature of the patterned functionalization was determined to be the ditopic scenario with fluorine atoms occupying the bottom side and moieties, such as oxygen‐containing groups or hydrogen atoms, binding on the top side, which provides information about the mechanism of the fluorination process. Our strategy can be conceptually extended to pattern other functionalities by using other reactants. Bottom‐side patterned functionalization enables utilization of the top side of a material, thereby opening up the possibilities for applications in graphene‐based devices.
Development and Industrialization of Liquid Crystalline Tolan. (1999)

Some series of novel nematic liquid crystalline tolans having high birefringence and low viscosity with a high NA (Nematic-to-Isotropic) transition temperature were developed in order to improve the response time of Supertwisted Nematic-Liquid Crystal Display (STN-LCD). Some nematic liquid crystalline mixtures of the tolans and other familiar series of nematic mixtures were prepared and their physical properties were compared. The drastic advantages of the tolans, which are useful for laptop computers and word processors, are demonstrated. Moreover, the details of industrialization of the tolans are described.
ChemInform Abstract: A Multinuclear NMR Study of Asymmetrically Coordinated η3‐Allyls in (PtCl(η3‐allyl)(phosphine)) and (Pt(phenyl)(η3‐allyl)(phosphine)) Complexes. (1989)

Abstract Title complexes of type (I) with R: Ph are prepared from their chloride analogues by simple metathesis using SnMe 3 Ph.
ptxD/Phi as alternative selectable marker system for genetic transformation for bio-safety concerns: a review (2021)

Antibiotic and herbicide resistance genes are the most common marker genes for plant transformation to improve crop yield and food quality. However, there is public concern about the use of resistance marker genes in food crops due to the risk of potential gene flow from transgenic plants to compatible weedy relatives, leading to the possible development of "superweeds" and antibiotic resistance. Several selectable marker genes such as <i>aph, nptII, aaC3, aadA, pat, bar, epsp and gat</i>, which have been synthesized to generate transgenic plants by genetic transformation, have shown some limitations. These marker genes, which confer antibiotic or herbicide resistance and are introduced into crops along with economically valuable genes, have three main problems: selective agents have negative effects on plant cell proliferation and differentiation, uncertainty about the environmental effects of many selectable marker genes, and difficulty in performing recurrent transformations with the same selectable marker to pyramid desired genes. Recently, a simple, novel, and affordable method was presented for plant cells to convert non-metabolizable phosphite (Phi) to an important phosphate (Pi) for developing cells by gene expression encoding a phosphite oxidoreductase (PTXD) enzyme. The <i>ptxD</i> gene, in combination with a selection medium containing Phi as the sole phosphorus (P) source, can serve as an effective and efficient system for selecting transformed cells. The selection system adds nutrients to transgenic plants without potential risks to the environment. The <i>ptxD</i>/Phi system has been shown to be a promising transgenic selection system with several advantages in cost and safety compared to other antibiotic-based selection systems. In this review, we have summarized the development of selection markers for genetic transformation and the potential use of the <i>ptxD</i>/Phi scheme as an alternative selection marker system to minimize the future use of antibiotic and herbicide marker genes.
Calnexin Overexpression Increases Manganese Peroxidase Production in Aspergillus niger (2002)

Heme-containing peroxidases from white rot basidiomycetes, in contrast to most proteins of fungal origin, are poorly produced in industrial filamentous fungal strains. Factors limiting peroxidase production are believed to operate at the posttranslational level. In particular, insufficient availability of the prosthetic group which is required for peroxidase biosynthesis has been proposed to be an important bottleneck. In this work, we analyzed the role of two components of the secretion pathway, the chaperones calnexin and binding protein (BiP), in the production of a fungal peroxidase. Expression of the Phanerochaete chrysosporium manganese peroxidase (MnP) in Aspergillus niger resulted in an increase in the expression level of the clxA and bipA genes. In a heme-supplemented medium, where MnP was shown to be overproduced to higher levels, induction of clxA and bipA was also higher. Overexpression of these two chaperones in an MnP-producing strain was analyzed for its effect on MnP production. Whereas bipA overexpression seriously reduced MnP production, overexpression of calnexin resulted in a four- to fivefold increase in the extracellular MnP levels. However, when additional heme was provided in the culture medium, calnexin overexpression had no synergistic effect on MnP production. The possible function of these two chaperones in MnP maturation and production is discussed.
GPx-1 Gene Delivery Modulates NF κ B Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex (2001)

Numerous environmental stimuli alter cell functions by the induction of intracellular reactive oxygen species, such as superoxide and hydrogen peroxide (H2O2). These redox alterations can change the activity of kinases and phosphatases responsible for controlling intracellular signal transduction cascades important in determining how cells react to their environment. One such well known pathway includes nuclear factor-kappaB (NFkappaB); however, the exact redox-sensitive factors important in controlling H2O2-mediated activation of NFkappaB remain unclear. In the present study, we have investigated how intracellular clearance of H2O2, using a recombinant adenovirus expressing glutathione peroxidase-1 (GPx-1), modulates NFkappaB activation following UV irradiation, tumor necrosis factor-alpha, or H2O2 treatment of MCF-7 cells. Findings from these studies demonstrate that GPx-1 overexpression can down-regulate NFkappaB DNA binding, and transcriptional activation of an NFkappaB-dependent luciferase reporter, to varying extents following these environmental stimuli. Studies using dominant negative adenoviral vectors expressing IKKalpha(KM) and IKKbeta(KA) suggest that GPx-1-mediated H2O2 clearance appears to preferentially inhibit the activity of IKKalpha, but not IKKbeta. These studies demonstrate for the first time that redox regulation of NFkappaB activation by intracellular H2O2 may be specific for a unique subunit in the IKK complex. Such findings suggest that IKK kinases or IKK phosphatases may have unique redox-regulated components. These studies have shed mechanistic insight into the potential application of redox-modulating gene therapies aimed at altering NFkappaB activation following environmental injury.
The Therapeutic Equivalence of IM and PO Administration of Morphine – 1:3 or 1:6? (1988)

When alternating between the intramuscular and oral routes of morphine adminstration, dosage adjust-ments must be made according to differences in rel-ative analgesic potency. While study has shown that six times as much morphine is required orally as intramuscularly to obtain the same total analgesic effect, anecdotal experience suggests that three times as much drug is required orally as is required parenterally. The following examines the arguments both for and against the two approaches to dose adjustment when alterations in route of administration are indicated. There is no compelling reason to change the use of the 1:3 ratio in cancer-related pain. The original experimental ratio of 1:6 is only an apparent inconsistency in that the conditions of dosing and other factors are most likely responsible for this apparent discrepancy. It will only be with a well-controlled study, however, conducted under appropriate conditions, that the 1:3 ratio can be confirmed.