gebhart/patrepeval huggingface dataset:
Deconvolution imaging conditions and cross-talk suppression (2010)

Abstract Deconvolution imaging conditions offer improved resolution over standard, crosscorrelation-based imaging conditions. Additionally, these imaging conditions produce a result more directly related to a reflection coefficient than do crosscorrelation-based imaging conditions. In simple analytical cases, deconvolution imaging conditions also offer the possibility of eliminating crosstalk (i.e., energy in the image due to reflected energy arriving at a location at the same time as incident energy that did not cause the reflected energy) when the full up- and down-going wavefields are used. This means that in such cases, surface-related multiples can be eliminated from the image, or that multiple shots could potentially be fired simultaneously without degrading the image. However, this cross-talk-suppression property is not observed in most situations. We show that this is due to a number of issues: the correct order of deconvolution must be used, stabilization causes imperfect deconvolution, finite apertures lead to some of the signal being lost, and an assumption of horizontal stratification is often not being met. Further, imperfect knowledge of the incident and reflected field due to such factors as anisotropy, poorly estimated velocity fields, and measurement noise can also lead to imperfect deconvolution. Thus, deconvolution imaging conditions should not be counted on to completely eliminate crosstalk from images.
Identification of a Set of Seven Genes for the Monitoring of Minimal Residual Disease in Pediatric Acute Myeloid Leukemia (2006)

This set of genes should allow a sensitive and specific monitoring of MRD in AML. Notably, some of these markers could also serve as therapeutic targets or might be involved in leukemogenesis. MSLN is already used as a target for immunotherapy in clinical trials in other malignancies.
Stromal features are predictive of disease mortality in oral cancer patients (2010)

Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year, with a rising incidence in many countries. Despite advances in surgery and radiotherapy, which remain the standard treatment options, the mortality rate has remained largely unchanged for decades, with a 5-year survival rate of around 50%. OSCC is a heterogeneous disease, staged currently using the TNM classification, supplemented with pathological information from the primary tumour and loco-regional lymph nodes. Although patients with advanced disease show reduced survival, there is no single pathological or molecular feature that identifies aggressive, early-stage tumours. We retrospectively analysed 282 OSCC patients for disease mortality, related to clinical, pathological, and molecular features based on our previous functional studies [EGFR, αvβ6 integrin, smooth muscle actin (SMA), p53, p16, EP4]. We found that the strongest independent risk factor of early OSCC death was a feature of stroma rather than tumour cells. After adjusting for all factors, high stromal SMA expression, indicating myofibroblast transdifferentiation, produced the highest hazard ratio (3.06, 95% CI 1.65-5.66) and likelihood ratio (3.6; detection rate: false positive rate) of any feature examined, and was strongly associated with mortality, regardless of disease stage. Functional assays showed that OSCC cells can modulate myofibroblast transdifferentiation through αvβ6-dependent TGF-β1 activation and that myofibroblasts promote OSCC invasion. Finally, we developed a prognostic model using Cox regression with backward elimination; only SMA expression, metastasis, cohesion, and age were significant. This model was independently validated on a patient subset (detection rate 70%; false positive rate 20%; ROC analysis 77%, p < 0.001). Our study highlights the limited prognostic value of TNM staging and suggests that an SMA-positive, myofibroblastic stroma is the strongest predictor of OSCC mortality. Whether used independently or as part of a prognostic model, SMA identifies a significant group of patients with aggressive tumours, regardless of disease stage.
Isolation, Propagation, and HIV-1 Infection of Monocyte-Derived Macrophages and Recovery of Virus From Brain and Cerebrospinal Fluid (2005)

Mononuclear phagocytes (MP: monocytes, dendritic cells, and tissue macrophages) are host cells for the human immunodeficiency viruses types 1 and 2. MPs are both the first lines of defense and vehicles for viral dissemination in the infected human host. Viral infection of MP can affect the disease directly during interstitial pneumonitis and HIV encephalitis. Both revolve around MP secretions of immune regulatory and neurotoxic factors. Clearly, laboratory models that mimic disease need to include primary human MP infected with viral isolates obtained from diseased tissues. Over the past two decades our laboratory has developed state-of-the-art methods for isolation and propagation of monocytes from peripheral blood. This technology directly supports work at the University of Nebraska Medical Center as well as research performed throughout the United States, including the laboratories of Drs. Mario Stevenson, William Tyor, David Volsky, Loyda Melendez, and Mary-Jane Potash, among others. The importance of these cells as targets for virus and reservoirs of persistent infection are discussed.
Immunotoxin Therapy for Cancer (1993)

DESPITE recent advances using conventional approaches (surgery, chemotherapy, and radiotherapy), most human cancers remain incurable. For those patients who have unresectable cancers at the time of diagnosis, the prognosis remains poor. It is clear that new therapeutic approaches are urgently needed. In the past decade, development of the hybridoma technique by Kohler and Milstein<sup>1</sup>and advances in protein chemistry have led to the development of immunotoxins, a new class of cytotoxic agents consisting of a protein toxin coupled to a monoclonal antibody or a growth factor.<sup>2-4</sup>These toxins are made by plants or bacteria and act by arresting protein synthesis; cell death rapidly follows. The plant toxins generally inactivate ribosomes by cleaving a specific sequence in the 60S rRNA. The bacterial toxins,<i>Pseudomonas</i>exotoxin A (PE) or diphtheria toxin (DT), ribosylate adenosine diphosphate residues, ribosylate and thereby inactivate elongation factor 2, which is necessary for protein synthesis. Several
Optical Phased Array Super-Cell Beyond the Reticle Limit (2023)

We present an optical phased array super-cell spanning four reticles and containing over 49,152 active elements. The device enables cross-reticle light routing between 24 OPAs, along with coherent combination using intra- and inter-reticle IQ receivers.
A randomised controlled trial of two feeding schedules in neonates weighing ≤1750 g (2009)

In comparison to a 2 hourly schedule, a 3 hourly feeding schedule did not decrease the incidence of feed intolerance; it, however, did not increase the incidence of hypoglycemia or apnea. For practical convenience, a 3 hourly feeding schedule may be preferred over 2 hourly schedule in neonates weighing <or=1750 g.
Fine-pitch probing on TSVs and microbumps using a chip prober having a transparent membrane probe card (2014)

For the chip-level pre-bond testing of a three-dimensional integrated circuit, we fabricated a transparent membrane probe card which had 20-μm-pitch probes on a polyethylene naphthalate film. It was fabricated by photolithography, Ti-Au sputtering, Au electroplating, Ni electroplating, electroless Au plating, and wet etching of the seed layer. Using the transparent membrane probe card and the chip prober, we could successfully conduct direct probing of 20-μm-pitch Cu-SnAg microbumps and through-silicon vias even when the tested chip was very thin (thickness: 30-50 μm).
Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics (2006)

RGS-PX1 (also known as sorting nexin 13) is a member of both the regulator of G protein signaling (RGS) and sorting nexin (SNX) protein families. Biochemical and cell culture studies have shown that RGS-PX1/SNX13 attenuates Galphas-mediated signaling through its RGS domain and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. To understand the functions of RGS-PX1/SNX13 in vivo, we generated mice carrying targeted mutations of Snx13 and found that systemic Snx13-null mice were embryonic lethal around midgestation. Snx13-null embryos had significant overall growth retardation and defects in neural tube closure, blood vessel formation, and the formation of the placental labyrinthine layer. Moreover, the Snx13-null visceral yolk sac endoderm cells showed dramatic changes in the organization of endocytic compartments, abundant autophagic vacuoles, and abnormal localization of several endocytic markers, including megalin, a receptor for nutrients and proteins; ARH, a coat protein that binds megalin; LAMP2; and LC3. These changes suggest that Snx13-null embryos are defective in nutrient uptake and transport, which may contribute to the other developmental abnormalities observed. Taken together, our findings demonstrate an essential role for RGS-PX1/SNX13 in mouse development and provide previously undescribed insights into its cellular function in the regulation of endocytosis dynamics.
Tempest and Typhoon: user-level shared memory (2002)

Future parallel computers must efficiently execute not only hand-coded applications but also programs written in high-level, parallel programming languages. Today's machines limit these programs to a single communication paradigm, either message-passing or shared-memory, which results in uneven performance. The authors address this problem by defining an interface, Tempest, that exposes low-level communication and memory-system mechanisms so programmers and compilers can customize policies for a given application. Typhoon is a proposed hardware platform that implements these mechanisms with a fully-programmable, user-level processor in the network interface. The authors demonstrate the utility of Tempest with two examples. First, the Stache protocol uses Tempest's fine-grain access control mechanisms to manage part of a processor's local memory as a large, fully-associative cache for remote data. The authors simulated Typhoon on the Wisconsin Wind Tunnel and found that Stache running on Typhoon performs comparably (/spl plusmn/30%) to an all-hardware Dir/sub N/NB cache-coherence protocol for five shared-memory programs. Second, they illustrate how programmers or compilers can use Tempest's flexibility to exploit an application's sharing patterns with a custom protocol. For the EM3D application, the custom protocol improves performance up to 35% over the all-hardware protocol.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: part 5 analysis of polymer relaxation phenomena for different polymers (2023)

Abstract The temperature dependent uptake of a commercial disperse dye on cotton and polyamide 66 fabrics at dyeing temperatures between 30°C and 130°C adhered to the Williams–Landel–Ferry equation, insofar as, very good correspondence was observed between plots of experimentally determined colour strength data points (log1/ f k ) and the respective structural relaxation times of the cellulose and nylon 66 polymers (log a T data points), as a function of the parameter ( T − T g ). Adsorption of the dye on both types of fibre therefore concurs with the fundamental precept of the free volume model of dye diffusion. Comparison of the adherence of the uptake of the commercial dye on cotton and polyamide 66 fabrics with that secured on polyester fabric revealed that despite the major chemical and physical differences between the three types of fibre, the same dyeing mechanism likely applies to each fibre type. The marked temperature dependent uptake of the commercial grade disperse dye each of the three types of substrate is the consequence of two, different, but inherently interconnected, thermally activated phenomena, namely the relaxation times of the molecular rearrangements occurring within the respective cellulose, nylon 66 or poly(ethylene terephthalate) macromolecule, in which polymer glass transition assumes the principal role, and the aqueous solubility of the commercial grade disperse dye.
Centimeter-Long and Large-Scale Micropatterns of Reduced Graphene Oxide Films: Fabrication and Sensing Applications (2010)

Recently, the field-effect transistors (FETs) with graphene as the conducting channels have been used as a promising chemical and biological sensors. However, the lack of low cost and reliable and large-scale preparation of graphene films limits their applications. In this contribution, we report the fabrication of centimeter-long, ultrathin (1-3 nm), and electrically continuous micropatterns of highly uniform parallel arrays of reduced graphene oxide (rGO) films on various substrates including the flexible polyethylene terephthalate (PET) films by using the micromolding in capillary method. Compared to other methods for the fabrication of graphene patterns, our method is fast, facile, and substrate independent. In addition, we demonstrate that the nanoelectronic FETs based on our rGO patterns are able to label-freely detect the hormonal catecholamine molecules and their dynamic secretion from living cells.
Determination of naproxen in serum by capillary electrophoresis with ultraviolet absorbance and laser‐induced fluorescence detection (1992)

Abstract Methodology for quantitative determination of an anti‐inflammatory drug, naproxen, in human serum by capillary electrophoresis (CE) is described. Ultraviolet absorbance (UV) and laser‐induced fluorescence (LIF) detection without derivatization procedures have been applied in two concentration ranges: the UV absorbance detection method is applicable in the concentration range of 0.5 ‐ 25 μg mL −1 (2 μM – 100 μM), permitting pharmacokinetic studies after a single oral dose of naproxen; for the lower concentration range of 0.01 – 0.5 μg mL −1 (40 nM ‐ 2 μM), LIF detection has been utilized. Sample preparation includes a simple liquid‐liquid extraction of 1.0 mL (UV) or 0.25 mL (LIF) serum aliquots. After solvent evaporation, redissolved samples were analyzed using Tris‐Tricine buffer. UV absorbance measurement was set at 254 nm. LIF using the helium‐cadmium (He‐Cd) laser as a source (excitation at 325 nm) was measured at 375 nm due to the native fluorescence of naproxen. Both methods provided interference‐free, linear and highly precise results. At the quantitation limit, 0.1‐pmol (UV) and 3‐fmol (LIF) naproxen levels were detected. Using ketoprofen (UV) and warfarin (LIF) as internal standards, analytical precision improved substantially.
Microwave near-field probes for photovoltaic applications (2011)

The photoresponse of three different photovoltaic Cu(In, Ga)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (CIGS) samples as well as GaAs and silicon bulk samples is measured using near-field scanning microwave microscopy (NSMM). Modeling predicts light-dependent conductivity values for bulk samples, as well as a preliminary understanding of more complicated multilayer photovoltaics. The spectral dependence of CIGS samples is probed at 405, 635, 808 and 980 nm wavelengths. In addition, we present two-dimensional raster scans that may reveal grain-boundary effects under illumination.
Smart Inverter for Voltage Regulation: Physical and Market Implementation (2018)

Lack of efficient coordination schemes between photovoltaic (PV) panels may result in voltage stability issues. In this paper, we exploit the power control potential enabled by the PV inverters for voltage regulation. There are considerable obstacles to design a viable coordination scheme. Physically, the power flow equations lead to a highly nonconvex constraint set. With respect to the market implementation, voltage regulation is predominately conducted by the system operator, and voltage regulation related products rarely exist. We cast the voltage regulation as a nonconvex optimization problem, and devise an analytical framework to show that based on a linearized model, one can design a gradient descent-based distributed scheme, which, when implemented in the nonconvex branch flow model, will converge to a local minimum exponentially fast. Additionally, we design a compensation scheme which incentivizes the PV panel owners to provide voltage regulation. The compensation naturally leads to a game between all the PV panel owners. By design, the equilibria coincide with the global minimizers to the social planner problem. Simulation results confirm the convergence rate of the control actions in practice.
Ring-opening polymerization of strained, ring-tilted metallocenophanes: A new route to organometallic polymers (1993)

The ring-opening polymerization of strained, ring-tilted metallocenophanes represents a new and versatile route to high molecular weight poly(ferrocenylsilanes). In this presentation the properties of poly(ferrocenylsilanes) will be described together with the relationships between the monomer structure, strain energy, and polymerization behavior. In addition, the extension of the ring opening route to the preparation of poly(ferrocenylgermanes) and poly(ferrocenylphosphines) will be outlined and the unusual properties of the polymers will be discussed.
Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere (2001)

Fancy drug candidates: The first preparation of indoloparacyclophanes is reported through the use of the Buchwald variant of the Fischer indole synthesis (see scheme). Receptor binding studies clearly demonstrated that the double-layered molecular scaffold can serve as an effective arylbioisostere. Supporting information for this article is available on the WWW under http://www.angewandte.com or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with 111In-DANBIRT (2018)

Our results indicate the potential of radiolabeled DANBIRT as a relevant imaging radioligand for non-invasive evaluation of atherosclerotic inflammation.
Facile C−C Bond Formation between Terminal Acetylenes and Olefines Leading to η3-Butadienyl and η2-Butadiene Complexes. A New Reaction Pathway for Metallacyclobutane Complexes (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFacile C−C Bond Formation between Terminal Acetylenes and Olefines Leading to η3-Butadienyl and η2-Butadiene Complexes. A New Reaction Pathway for Metallacyclobutane ComplexesChristian Slugovc, Kurt Mereiter, Roland Schmid, and Karl KirchnerView Author Information Institute of Inorganic Chemistry and Institute of Mineralogy, Crystallography, and Structural Chemistry Technical University of Vienna Getreidemarkt 9, A-1060 Vienna, Austria Cite this: J. Am. Chem. Soc. 1998, 120, 24, 6175–6176Publication Date (Web):June 5, 1998Publication History Received11 February 1998Published online5 June 1998Published inissue 1 June 1998https://pubs.acs.org/doi/10.1021/ja9804722https://doi.org/10.1021/ja9804722rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views309Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical reactions,Chemical structure,Hydrocarbons,Vinyl,Vinylidene group Get e-Alerts
Laser-Induced Backside Wet Etching Employing Green DPSS Laser and Liquid Metallic Absorber (2011)

An indirect laser processing, laser-induced backside wet etching (LIBWE) is one of effective techniques for flexible laser-direct-write (LDW) type micromachining of transparent materials. Micromachining by LIBWE employing a diode-pumped solid state (DPSS) green laser and a galvanometer-based point scanning system was examined with employing organic dye solution and liquid metal as laser-absorbing media. LIBWE using liquid metal absorber showed smaller threshold pulse energies for etching (9.1 J/pulse) than that using organic dye solution (33 J/pulse). Different morphologies of etched surfaces were observed for different laser-absorbing media, indicating different mechanisms involved in the etching processes. The laser-induced dynamic phenomena were investigated by means of transient reflection measurements. The different contribution of direct and indirect actions of laser pulses was indicated for LIBWE employing different laser-absorbing media.
Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor (2013)

Leptin receptors play critical roles in mediating leptin's pleiotropic effects on mammalian physiology. To date, six splice variants of the leptin receptor gene have been identified [1-3]. These splice variants have identical extracellular leptin binding motifs but different intracellular C termini. The finding that mutations specifically ablating the function of ObRb cause obesity has established a critical role for this isoform in leptin signaling [1,7]. ObRa is the most abundant splicing isoform with a broad tissue distribution [5], and it has been proposed to play roles in regulating leptin bioavailability, CSF (cerebrospinal fluid) transport and function by forming heterodimers with ObRb and also activating signal transduction via JAK2 in-vitro [5-10]. To assess the in-vivo role of ObRa, we generated an ObRa KO mouse by deleting the ObRa-specific exon 19a. Homozygous mutant mice breed normally and are indistinguishable from wild-type mice on regular chow diet, but show a slightly increased basal plasma leptin, a slight improvement of their GTT and a slightly reduced response to systemic leptin administration. These mice also show a modest but statistically significant increase in weight when placed on a high fat diet with a slightly reduced CSF/plasma ratio of leptin. These data suggest that ObRa plays a role in mediating some of leptin's effects but that the phenotypic consequences are modest compared to a deletion of ObRb.