gebhart/patrepeval huggingface dataset:
Manganese Catalyzed Partial Oxidation of Light Alkanes (2022)

The catalytic partial oxidation of methane is achieved at low temperatures (<200 °C) using manganese oxides and manganese salts in mixtures of trifluoroacetic acid and trifluoroacetic anhydride. Dioxygen is used as the in situ terminal oxidant. For Mn oxides (e.g., MnO2, Mn2O3, and Mn3O4), we studied stoichiometric methane partial oxidation in HTFA (TFA = trifluoroacetate). Using a Mn trifluoroacetate salt, at 180 °C and under 25 psig of methane, product selectivity for the mono-oxidized product methyl trifluoroacetate (MeTFA) is observed to be >90% at ∼35% methane conversion at approximately 6 turnovers. Under our catalytic methane oxidation reaction conditions, MeTFA is stable against overoxidation, which explains the likely high selectivity at conversions >15%. Using combined experimental studies and DFT calculations, a mechanism involving soluble and molecular Mn species in the catalytic cycle is proposed. The proposed reaction pathway involves initial activation of MnII by dioxygen, cleavage of a methane C–H bond by a MnIII hydroxo intermediate, rebound of the methyl radical to generate MeTFA, and finally regeneration of the starting MnII complex. Also, this process is shown to be applicable to the oxidation of ethane, favoring the mono-oxidized product ethyl trifluoroacetate (EtTFA) and reaching ∼46% conversion.
Adaptive transmission timing control using reservation packet in reverse link for broadband DS-CDMA wireless access (2003)

The paper proposes an adaptive transmission timing control (ATTC) method using reservation packets for broadband variable spreading factor (VSF) CDMA wireless access in the reverse link, in order to increase the link capacity while maintaining advantages such as one-cell frequency reuse in a cellular system in a multi-cell configuration. The difference in the received reservation packet timing due to the propagation delay time is measured by utilizing reservation packets that contain small amounts of information, such as the data types (real-time or non-real time) and the size of the traffic bits in the packet data channel. The transmission timings of the successive packet data channels are controlled so that the received timings of the highest signal power path of the packet data channels of simultaneously accessing users are aligned. The simulation results show that by applying ATTC using reservation packets, the required average received signal energy per bit-to-background noise power spectrum density ratio (E/sub b//N/sub 0/) at the average packet error rate of 10/sup -1/ is decreased by approximately 6(1) dB compared to the case without ATTC and the loss in the required average received E/sub b//N/sub o/ from the ideal received timing alignment is 1(0.5) dB, for a six(four)-user environment associated with the spreading factor of SF=8 and in a three-path Rayleigh fading channel, because the dominant multiple access interference, caused by the highest signal power path for each user, is suppressed.
Proposal for an Accelerator R&amp;D User Facility at Fermilab's Advanced Superconducting Test Accelerator (ASTA) (2013)

Fermilab is the nation’s particle physics laboratory, supported by the DOE Office of High Energy Physics (OHEP). Fermilab is a world leader in accelerators, with a demonstrated track-record— spanning four decades—of excellence in accelerator science and technology. We describe the significant opportunity to complete, in a highly leveraged manner, a unique accelerator research facility that supports the broad strategic goals in accelerator science and technology within the OHEP. While the US accelerator-based HEP program is oriented toward the Intensity Frontier, which requires modern superconducting linear accelerators and advanced highintensity storage rings, there are no accelerator test facilities that support the accelerator science of the Intensity Frontier. Further, nearly all proposed future accelerators for Discovery Science will rely on superconducting radiofrequency (SRF) acceleration, yet there are no dedicated test facilities to study SRF capabilities for beam acceleration and manipulation in prototypic conditions. Finally, there are a wide range of experiments and research programs beyond particle physics that require the unique beam parameters that will only be available at Fermilab’s Advanced Superconducting Test Accelerator (ASTA). To address these needs we submit this proposal for an Accelerator R&D User Facility at ASTA. The ASTA program is based on the capability provided by an SRF linac (which provides electron beams from 50 MeV to nearly 1 GeV) and a small storage ring (with the ability to store either electrons or protons) to enable a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop transformative approaches to particle-beam generation, acceleration and manipulation which cannot be done elsewhere. It will also establish a unique resource for R&D towards Energy Frontier facilities and a test-bed for SRF accelerators and high brightness beam applications in support of the OHEP mission of Accelerator Stewardship.
Arginine-Induced Insulin Release in Relation to the Cyclic AMP System in Man (1972)

The insulin-releasing action of the amino acid arginine in man is inhibited by hypoglycemia. Furthermore, arginine potentiates glucose-induced insulin release, probably by amplifying the insulinogenic signal evoked by glucose in the beta-cell. The beta-adrenergic blocking agent propranolol, in doses known to suppress glucose-induced insulin release, did not alter insulin response to arginine infusion. Arginine markedly augments insulin release secondary to glucose whereas, under the same experimental conditions, it has no effect on insulin release secondary to glucagon. Finally, pretreatment with aminophylline potentiated the insulinogenic potency of the amino acid. We have previously postulated that glucose elicits insulin release by acting directly on a specific cell membrane receptor. The signal thus evoked is probably mediated through the adenyl cyclase-cyclic AMP system. In the light of this hypothesis and the above results we suggest that arginine acts on the beta-cell by amplifying the transmission of the glucose-induced signal at a locus between the glucose receptor and cyclic AMP.
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers: Correlative Results from AZD9496 Oral SERD Phase I Trial (2018)

Elevated CTC at baseline was a strong prognostic factor in this cohort. Early on-treatment changes were observed in CTC-ER<sup>+</sup> and <i>ESR1<sub>LBD</sub>m</i> <sup>+</sup> ctDNA, but not in overall CTC number. Integrating multiple biomarkers in prospective trials may improve outcome prediction and ET resistance mechanisms' identification over a single biomarker.
Photoluminescence from suspended Ge/SiGe quantum-well microdisks (2015)

We demonstrate, for the first time, the photoluminescence from suspended Ge/SiGe quantum-well microdisks. The optical mode resonances of the photoluminescence spectra are associated with Fabry-Perot modes and whispering gallery modes.
Adaptive Sensor Data Compression in IoT systems: Sensor data analytics based approach (2015)

Sensor nodes are embodiment of IoT systems in microscopic level. As the volume of sensor data increases exponentially, data compression is essential for storage, transmission and in-network processing. The compression performance to realize significant gain in processing high volume sensor data cannot be attained by conventional lossy compression methods. In this paper, we propose ASDC (Adaptive Sensor Data Compression), an adaptive compression scheme that caters various sensor applications and achieve high performance gain. Our approach is to exhaustively analyze the sensor data and adapt the parameters of compression scheme to maximize compression gain while optimizing information loss. We apply robust statistics and information theoretic techniques to establish the adaptivity criteria. We experiment with large sets of heterogeneous sensor datasets to prove the efficacy. Nonlinear lossy compression (Chebyshev) is extensively considered as the standard technique as well as experimental result with frequency domain compression like Discrete Fourier Transform (DFT) is shown as future scope of further improvement.
A cathode mounted plasma prefill source for high power microwave experiments (2002)

The introduction of a plasma into the slow-wave structure (SWS) of a backward wave oscillator (BWO) has been shown to increase microwave power output and generation efficiency, as well as provide several other benefits. Two methods of generating the plasmas are electron beam impact ionization of a background gas and prefilling through use of an external plasma source. It has been shown that optimally the plasma should be confined near the axis of the SWS, while the electron beam driving the device should be as close to the walls as possible. Previous plasma-filled BWO experiments used external plasma sources that were mounted in the microwave extraction region of the BWO, making use of the electron beam's guiding magnetic field to compress the plasma onto the axis as it enters the SWS. At the University of New Mexico a plasma source has been developed for the UNM Long-Pulse BWO Experiment which can be mounted upstream of the SWS, directly into the cathode stalk of the electron beam diode. This source utilizes a flashboard, similar to the kind used in plasma opening switches, to create the plasma. Plasma is injected directly onto the axis of the SWS, and since the source hardware has been removed from the extraction region, problems with coupling out the microwave power are eliminated, and the amount of plasma in this region is reduced. Data such as plasma density at different axial positions in the BWO without the electron beam is presented, followed by a discussion on the changes in BWO performance when the experiment is fired with the addition of this plasma. Details of the novel plasma injection system are also presented.
Synthesis of 3‐alkyl‐8‐substituted‐ and 4‐hydroxy‐8‐substituted‐2,3,4,5‐tetrahydro‐1H‐2‐benzazepines (1994)

Abstract Based on the Schmidt reaction and an iodolactone ring expansion reaction, two different synthetic routes to substituted 2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepines were developed. The Schmidt reaction on 2,3‐dihydro‐2 H ‐1‐naphthalenone ( 1 ) gave 3 , the product resulting from the alkyl group migration, as the major product instead of the tetrazole 2. This prompted the investigation of the Schmidt reaction on aromatic ketones 8 and 12. The product 9 due to alkyl group migration was the major product of the Schmidt reaction on 2‐methyl‐3,4‐dihydro‐2 H ‐1‐naphthalenone ( 8 ). The β‐keto diester 12 gave a mixture of decarb‐oxylated lactams after the Schmidt reaction. In this case, the lactam 13 resulting from the migration of the aromatic ring dominated over the other lactam 14. When lactam 14 was subjected to nitration, a single regioisomer was produced and transformed to the bromo alcohol 19. The other approach was based on the single pot ring expansion of the iodolactone 22 to the lactam 23 in the presence of methanolic ammonia. The iodolactone 22 was readily prepared from 2‐allylbenzoic acid.
Optimization of the information chain within the engineering process of production systems (2013)

Engineering processes of complex production systems have an increasing impact on the life cycle costs of the production systems. Thus, it is naturally of interest to optimize them with respect to correctness and efficiency. Therefore, methods for process modeling and problem identification are required, applicable also by engineers not familiar with process modeling but with their own engineering process. Within this paper such a method is described and first application experiences are given.
Development Of Courses In Consumer Electronics (2020)

has established an undergraduate educational project for Consumer Electronics 1 . The goal of the educational project is to introduce students to electronic design by the disassembly, analysis, and redesign of consumer electronics products
Identification and Quantification of AKT Isoforms and Phosphoforms in Breast Cancer Using a Novel Nanofluidic Immunoassay (2013)

Breast cancer subtype-specific molecular variations can dramatically affect patient responses to existing therapies. It is thought that differentially phosphorylated protein isoforms might be a useful prognostic biomarker of drug response in the clinic. However, the accurate detection and quantitative analysis of cancer-related protein isoforms and phospho-isoforms in tumors are limited by current technologies. Using a novel, fully automated nanocapillary electrophoresis immunoassay (NanoPro(TM) 1000) designed to separate protein molecules based on their isoelectric point, we developed a reliable and highly sensitive assay for the detection and quantitation of AKT isoforms and phosphoforms in breast cancer. This assay enabled the measurement of activated AKT1/2/3 in breast cancer cells using protein produced from as few as 56 cells. Importantly, we were able to assign an identity for the phosphorylated S473 phosphoform of AKT1, the major form of activated AKT involved in multiple cancers, including breast, and a current focus in clinical trials for targeted intervention. The ability of our AKT assay to detect and measure AKT phosphorylation from very low amounts of total protein will allow the accurate evaluation of patient response to drugs targeting activated PI3K-AKT using scarce clinical specimens. Moreover, the capacity of this assay to detect and measure all three AKT isoforms using one single pan-specific antibody enables the study of the multiple and variable roles that these isoforms play in AKT tumorigenesis.
Experimental and Numerical Studies on a New Type of Spray Axial-Flow Fan (2012)

A new spray axial-flow fan with a ring-shaped spray-generating device in the upstream of the rotor is proposed in this paper. The characteristics of the new spray axial-flow fan were tested in detailed according to the international performance test standard. The experimental results showed that the characteristics of the new fan operating with working fluid which having a high water-air mass ratio have been improved obviously, compared with those of the existing spray fan with the conventional spray-generating device. The new spay fan considerably expands the limit on the water-air mass ratio of the working fluid, beyond which the motor of the spray fan may be over loaded, due to its much lower decrease slope of total pressure efficiency and much lower increment slope of shaft power against the increase in the water-air mass ratio of the working fluid. In addition, its utilization factor of sprayed water also increases obviously. Numerical investigations on this new fan with working fluid under the air phase or the mixed air-water phase were also conducted. The results indicated that the numerical results agree well with the experimental data with air as the working fluid. This verified the validity of computational models. However, the numerical results using the discrete phase model available in the Fluent program for the mixed air-water working fluid showed an evident deviation from the experimental results. The numerical simulations underestimate the deteriorating effect of the characteristics of the spay fan with water added, which means it cannot well simulate and analyze the complex flow filed inside the spay fan. Further research is needed to explore the mechanism for the deteriorated characteristics of the spray fan.
ChemInform Abstract: Greatly Enhanced Second‐Order Nonlinear Optical Susceptibilities in Donor‐Acceptor Organic Molecules. (1988)

Abstract Optical susceptibilities can be increased substantially through the use of di‐ or tricyanovinyl as acceptor and/or dithiolylidenemethyl as donor groups as exemplified by compounds (I)‐(IV).
Phase behavior of aqueous mixtures of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase behavior of aqueous mixtures of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS)Kathleen L. Herrington, Eric W. Kaler, David D. Miller, Joseph A. Zasadzinski, and Shivkumar ChiruvoluCite this: J. Phys. Chem. 1993, 97, 51, 13792–13802Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/j100153a058https://doi.org/10.1021/j100153a058research-articleACS PublicationsRequest reuse permissionsArticle Views2862Altmetric-Citations350LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Study on adsorption of lead by biochar prepared from sludge of municipal wastewater treatment plant (2019)

In general, with the increase of pyrolysis temperature, the adsorption effect of the prepared biochar to Pb2+ is better.Under the same experimental conditions at 25°C, the adsorption capacity of biochar prepared by pyrolysis of sludge at 600°C was highest which was 611.8 mg/g. The adsorption kinetics of Pb2+ in solution by BC600 is better fitted to the first order kinetic equation. With the increase of pH value of solution, the adsorption capacity of lead increased from 441.3 mg/g to 650.6 mg/g.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance (2022)

Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human cancer progression as well as a target for neurodegenerative diseases, including Alzheimer's. Moreover, knockdown of PLD rescues the ALS phenotype in multiple <i>Drosophila</i> models of ALS (amyotrophic lateral sclerosis) and displays modest motor benefits in an SOD1 ALS mouse model. To further validate whether inhibiting PLD is beneficial for the treatment of ALS, a brain penetrant small molecule inhibitor with suitable PK properties to test in an ALS animal model is needed. Using a combination of ligand-based drug discovery and structure-based design, a dual PLD1/PLD2 inhibitor was discovered that is single digit nanomolar in the Calu-1 cell assay and has suitable PK properties for <i>in vivo</i> studies. To capture the <i>in vivo</i> measurement of PLD inhibition, a transphosphatidylation pharmacodynamic LC-MS assay was developed, in which a dual PLD1/PLD2 inhibitor was found to reduce PLD activity by 15-20-fold.
Grid allocation and reservation---Toward a doctrine of containment (2006)

Grid computing environments need secure resource control and predictable service quality in order to be sustainable. We propose a grid hosting model in which independent, self-contained grid deployments run within isolated containers on shared resource provider sites. Sites and hosted grids interact via an underlying resource control plane to manage a dynamic binding of computational resources to containers. We present a prototype grid hosting system, in which a set of independent Globus grids share a network of cluster sites. Each grid instance runs a coordinator that leases and configures cluster resources for its grid on demand. Experiments demonstrate adaptive provisioning of cluster resources and contrast job-level and container-level resource management in the context of two grid application managers.
Effects of cryoprotectants and ice-seeding temperature on intracellular freezing and survival of human oocytes (1999)

The accurate determination of the freezing conditions that promote intracellular ice formation (IIF) is crucial for designing cryopreservation protocols for cells. In this paper, the range of temperatures at which IIF occurs in human oocytes was determined. Fresh oocytes with a germinal vesicle, failed-to-fertilize (metaphase I and metaphase II stages) and polyspermic eggs were used for this study. The occurrence of IIF was first visualized at a cooling rate of 120 degrees C/min using a programmable thermal microscope stage connected to a videomicroscope. Then, with a cooling rate of 0.2 degrees C/min, the seeding temperature of the extracellular ice was modified to decrease the incidence of IIF and increase the survival rate of frozen-thawed human oocytes. After adding different cryoprotectants, the median temperature of IIF (TMED) was decreased by approximately 23 degrees C in mouse and only by approximately 6.5 degrees C in human oocytes. Using 1.5 M propylene glycol and seeding temperatures of -8.0, -6.0 and -4.5 degrees C, the incidence of IIF was 22/28 (78%), 8/24 (33%) and 0/33 (0%) and the 24 h post-thaw survival rate was 10/31(32%), 19/34 (56%) and 52/56 (93%) respectively. The results show that IIF occurs more readily in human oocytes, and that ice seeding between -6 degrees C and -8 degrees C triggers IIF in a large number of human oocytes. Undesirable IIF can be prevented and survival rates maximized by raising the seeding temperature as close as possible to the melting point of the solution, which in our instrument was -4.5 degrees C.
ChemInform Abstract: Synthesis and Antibacterial Activity of Some Novel 1‐Substituted 1,4‐ Dihydro‐4‐oxo‐7‐pyridinyl‐3‐quinolinecarboxylic Acids. Potent Antistaphylococcal Agents. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Urban-rural differences in a population-based breast cancer screening program in Croatia (2011)

Identification of rural-urban differences in mammography use and their causes at the population level can be useful in designing and implementing interventions targeted at the reduction of inequalities and modifiable risk factors.