gebhart/patrepeval huggingface dataset:
Production of biological active murine IFN-Î³ by recombinant Lactococcus lactis (2008)

IFN-gamma is a cytokine produced primarily by both T lymphocytes and natural killer cells and it is considered to be an attractive therapeutic molecule. In the present study, a DNA sequence encoding the mature murine IFN-gamma (muIFN-gamma) protein was cloned and expressed in the food-grade lactic acid bacterium Lactococcus lactis. The activity of recombinant muIFN-gamma produced by genetically engineered L. lactis was confirmed in an antiviral assay using MoV cells infected with Vesicular Stomatitis Virus. The data provide the first demonstration that a Gram-positive bacterium, L. lactis, is able to produce functional muIFN-gamma. This recombinant strain could lead to the development of a new, well-tolerated vector to deliver active muIFN-gamma at the mucosal level.
Low Density Lipoproteins Modulate Collagen Metabolism in Fibroblasts (2003)

High levels of low-density lipoprotein are associated with atherosclerosis, and myocardial and arterial remodeling. We postulated that low-density lipoprotein influences collagen synthesis and degradation in fibroblasts as a potential mechanism of tissue remodeling. Incubation of cultured human skin fibroblasts with low-density lipoproteins resulted in a time-dependent and dose-dependent increase in the secretion of matrix metalloproteinase activity measured by gelatin zymography. Western blot analysis showed a concomitant increase in matrix metalloproteinase-1 protein. Northern blot analysis demonstrated an increase in collagen I messenger RNA after treatment with low-density lipoprotein. The matrix metalloproteinase-1 secretory response of fibroblasts to low-density lipoprotein was attenuated by heparin, which inhibits low-density lipoprotein uptake through the low-density lipoprotein-receptor. These observations suggest that low-density lipoprotein has a regulatory effect on collagen metabolism in fibroblasts.
Training ensemble of diverse classifiers on feature subsets (2014)

Ensembles of diverse classifiers often out-perform single classifiers as has been well-demonstrated across several applications. Existing training algorithms either learn a classifier ensemble on pre-defined feature sets or independently perform classifier training and feature selection. Neither of these schemes is optimal. We pose feature subset selection and training of diverse classifiers on selected subsets as a joint optimization problem. We propose a novel greedy algorithm to solve this problem. We sequentially learn an ensemble of classifiers where each subsequent classifier is encouraged to learn data instances misclassified by previous classifiers on a concurrently selected feature set. Our experiments on synthetic and real-world data sets show the effectiveness of our algorithm. We observe that ensembles trained by our algorithm performs better than both a single classifier and an ensemble of classifiers learnt on pre-defined feature sets. We also test our algorithm as a feature selector on a synthetic dataset to filter out irrelevant features.
Delay Skew Packet Flow Control in Wireless Systems With Dual Connectivity (2018)

The paper presents a new data flow controller for use in 4G and 5G wireless applications where the incoming internet data flow is split in support of multipoint downlink wireless transmission. The different paths of the data from the node of the split to the wireless transmission nodes and on to the mobile may then result in different travel times. The mobile can cope with small values of this delay skew by means of buffers and reordering protocols. The control objective is therefore to keep the delay skew within a prespecified interval of time, when the packets arrive in the mobile. The proposed algorithm solves the problem by cascade control. The packet dwell time of each wireless transmission node data queue is controlled by an inner loop, with the reference dwell times being determined by an outer delay skew control loop. The delay skew control loop exploits a deadzone to achieve interval control. In a further contribution the L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -stability of the controller is analyzed for the dual connectivity functionality of the coming 5G cellular network deployment. A combined use of the input-output Nyquist- and Popov-criteria is required for the analysis. The performance is also evaluated by a laboratory testbed implementation.
Registration of Spherical Panoramic Images with Cadastral 3D Models (2012)

The availability of geolocated panoramic images of urban environments has been increasing in the recent past thanks to services like Google Street View, Microsoft Street Side, and Navteq. Despite the fact that their primary application is in street navigation, these images can be used, along with cadastral information, for city planning, real-estate evaluation and tracking of changes in an urban environment. The geolocation information, provided with these images, is however not accurate enough for such applications: this inaccuracy can be observed in both the position and orientation of the camera, due to noise introduced during the acquisition. We propose a method to refine the calibration of these images leveraging cadastral 3D information, typically available in urban scenarios. We evaluated the algorithm on a city scale dataset, spanning commercial and residential areas, as well as the countryside.
The Relationship Between Copeptin Level and Enuresis in Children Aged 5 - 15 Years (2023)

Background: Enuresis is bedwetting that occurs during sleep in children over five years old. If left untreated, it can lead to social and psychological problems for children and their parents. The role of copeptin in patients with primary monosymptomatic nocturnal enuresis (PMNE) has been reported in several studies. Due to the favorable structural properties of copeptin and the reflection of arginine vasopressin (AVP) concentration, it can be used as an alternative marker for AVP secretion. Objectives: This study aims to compare the levels of copeptin in healthy and enuresis children aged 5 - 15 years. Methods: This case-control study was performed on 42 children with primary monosymptomatic enuresis and 42 children without enuresis who were referred to the clinic of Taleghani hospital in Gorgan in 2020. Copeptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) method. Results: Out of 84 patients, an equal proportion of girls (21 patients) and boys (21 patients) participated in both the case and control groups. The age of the children was 8.05 ± 2.46 years, and there was no statistically significant difference between the two groups (P = 0.16). The mean level of copeptin in the case and control groups were 6.7 ± 4.27 and 6.87 ± 8.52 pg/mL, respectively, significantly lower in the case group (P = 0.03). There was a statistically significant difference in the level of copeptin between the boys in the two groups (P = 0.03). Although the mean level of copeptin in the girls in the patient group was lower than that in the control group, this difference was not statistically significant (P = 0.35). Conclusions: In this study, the mean level of copeptin in PMNE was significantly lower than that in the control group, which suggests it may be considered as a probable biomarker for the prediction of response to treatment with desmopressin, but further study is required to confirm this hypothesis.
Structure-Activity Studies on Alpha-Conotoxins (2011)

Conotoxins are small bioactive highly structured peptides from the venom of marine cone snails (genus Conus). Over the past 50 million years these molluscs have developed a complex venom cocktail for each species that is comprised of 100-2000 distinct cysteine- rich peptides for prey capture and defence. This review focuses on an important and well-studied class of conotoxins, the α- conotoxins. These α-conotoxins are potent and selective antagonists of various subtypes of the nicotinic acetylcholine receptors (nAChRs). Key structure-activity relationship studies are presented to illustrate the common motifs, structural features and pharmacophores that define this interesting peptide class. Additionally, their synthesis, chemical modifications, the development of more selective and stable analogues and their therapeutic potential are discussed.
Reconfigurable dipole receive array for dynamic parallel imaging at ultra‐high magnetic field (2023)

We presented an 8-element prototype of a novel electronically reconfigurable dipole receive array that permits rapid sensitivity modulations along the dipole axes. Applying dynamic sensitivity modulation during image acquisition emulates two virtual rows of receive elements along the z-direction, and therefore improves parallel imaging performance for 3D acquisitions.
Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE (2022)

The FullMonte open source suite enables easier and more cost-effective in-silico studies for iPDT.
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model (2023)

Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal responses to immune challenges as well as fail to develop antigen-specific B or T cell memory. Here we report HIS mice mediate spontaneous regression of human B cell lymphoma Raji. Tumor regression was dependent on CD4+ and CD8+ T cell responses and resulted in T cell memory. The T cell memory elicited was mainly Raji-specific, however some level of cross-protection was also elicited to a related B cell lymphoma cell line Ramos. Single-cell RNAseq analysis indicated activation of CD8+ T cells in regressing Raji tumors as well as clonal expansion of specific T cell receptors (TCRs). Cloning of TCRs from Raji-infiltrating T cells into a Jurkat reporter cell line showed reactivity specific for Raji tumor cells. Overall, we report a platform for studying in vivo human T cell tumor immunity by highlighting spontaneous Raji tumor regression, clonal TCR expansion, and T cell memory in HIS mice.
Lewis acid assisted condensations between a 5-methoxyisoxazolidine and silicon-based nucleophiles: .gamma.-amino alcohol building block in the synthesis of agroclavine I (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLewis acid assisted condensations between a 5-methoxyisoxazolidine and silicon-based nucleophiles: .gamma.-amino alcohol building block in the synthesis of agroclavine IAlan P. Kozikowski and Philip D. SteinCite this: J. Am. Chem. Soc. 1985, 107, 8, 2569–2571Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/ja00294a072https://doi.org/10.1021/ja00294a072research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Enhanced thermal stability of biomedical thermoplastic polyurethane with the addition of cellulose nanocrystals (2015)

ABSTRACT Freeze‐dried cellulose nanocrystals (CNCs) were dispersed in the thermoplastic polyurethane [Pellethane 2363‐55D (P55D)] by a solvent casting method to fabricate CNC‐reinforced nanocomposites. This study demonstrated that the addition of small amounts (1–5 wt %) of CNCs to P55D increased the thermal degradation temperature while maintaining a similar stiffness, strength, and elongation of the neat P55D. CNC additions to P55D did not alter the glass‐transition temperature, but the onset decomposition temperature was shifted from 286 to 327°C when 1 wt % CNCs was dispersed in the matrix. The higher onset decomposition temperature was attributed to the formation of hydrogen bonds between the hydroxyl groups on the CNC surface and urethane groups in the hard block of P55D. The ultimate tensile strength and strain to failure (ε f ) of the nanocomposites were minimally affected by additions up to 5 wt % CNCs, whereas the elastic modulus was increased by about 70%. The observation that ε f was unchanged with the addition of up to 5 wt % CNCs suggested that the flow/sliding of the hard blocks and chains were not hindered by the presence of the CNCs during plastic deformation. The ramifications of this study was that CNC additions resulted in wider processing temperatures of P55D for various biomedical devices while maintaining a similar stiffness, strength, and elongation. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41970.
ChemInform Abstract: Aldol‐Equivalent Elaboration of Sterically Hindered Ketones: Methallylmagnesium Chloride as a Synthon for Acetone Enolate. (1987)

Abstract The sterically hindered or cyclic ketones (I) react with methallylmagnesium chloride (II) to form the alcohols (III) which undergo ozonolysis to yield the ketols (IV).
YouTube Can Do Better: Getting the Most Out of Video Adaptation (2016)

YouTube, as one of the major HTTP Adaptive Streaming video services, accounts for a large fraction of today's Internet traffic. Therefore, it is important to understand how efficiently YouTube uses available network resources. Previous work observed that the YouTube player replaces previously buffered segments with higher quality segments. This is good for the user as it increases the average quality level. However, the lower quality level segments are discarded and their traffic is redundant and therefore wasted. In this paper, we use two independent approaches to evaluate the efficiency of YouTube's quality adaptation algorithm. The first approach performs regression based on previously collected video views from a large experimental data set. In the second approach we formulate a mixed integer linear program and calculate the optimal video quality adaptation. The results show that the simplistic regression approach gives an accurate estimation of the optimal adaptation. Furthermore, the optimization shows that the Quality of Experience (QoE) can be significantly improved compared to the actual average quality level observed in the real-world experiments, demanding for better video quality adaptation mechanisms by YouTube.
Screening for Important Base Identities in the Hairpin Ribozyme by In Vitro Selection for Cleavage (1998)

Random mutagenesis followed by an in vitro selection procedure was shown to be capable of identifying important bases of the hairpin ribozyme for cleavage of an RNA target sequence. The selection scheme enriched the RNA population for those molecules capable of efficient site-specific self-cleavage in the absence of ligation. Cleavable mutants were selected for all positions in loop 4 except for position A38, supporting the notion that A38 is an important base in the hairpin ribozyme. This has been confirmed by direct mutagenesis, validating the utility of this procedure. Thus, the method developed and reported here has utility for the selection of efficient hairpin ribozymes capable of highly efficient cleavage of a substrate RNA without a requirement for ribozyme-catalyzed ligation, conditions desired for many applications of catalytic RNA such as gene therapy.
Capture and inception of bubbles near line vortices (2005)

Motivated by the need to predict vortex cavitation inception, a study has been conducted to investigate bubble capture by a concentrated line vortex of core size rc and circulation Γ0 under noncavitating and cavitating conditions. Direct numerical simulations that solve simultaneously for the two phase flow field, as well as a simpler one-way coupled point-particle-tracking model (PTM) were used to investigate the capture process. The capture times were compared to experimental observations. It was found that the point-particle-tracking model can successfully predict the capture of noncavitating small nuclei by a line vortex released far from the vortex axis. The nucleus grows very slowly during capture until the late stages of the process, where bubble/vortex interaction and bubble deformation become important. Consequently, PTM can be used to study the capture of cavitating nuclei by dividing the process into the noncavitating capture of the nucleus, and then the growth of the nucleus in the low-pressure core region. Bubble growth and deformation act to speed up the capture process.
Desymmetrization of Vicinal Bis(boronic) Esters by Enantioselective Suzuki–Miyaura Cross-Coupling Reaction (2023)

The development of an enantioselective catalytic Suzuki-Miyaura reaction that applies to <i>meso</i> 1,2-diborylcycloalkanes is described. This reaction provides a modular route to enantiomerically enriched substituted carbocycles and heterocycles that retain a synthetically versatile boronic ester. With appropriately constructed substrates, compounds bearing additional stereogenic centers and fully substituted carbon atoms can be generated in a straightforward fashion. Preliminary mechanistic experiments suggest that substrate activation arises from the cooperative effect of vicinal boronic esters during the transmetalation step.
Generation of 1.024-Tb/s Nyquist-WDM Phase-Conjugated Twin Vector Waves through Polarization-Insensitive Optical Parametric Amplification Enabling Transmission over 4000-km Dispersion-Managed TWRS Fiber (2013)

We experimentally demonstrate the first Tb/s Nyquist-WDM phase-conjugated twin waves, consisting of eight 128-Gb/s PDM-QPSK signals and their idlers, by a broadband polarization-insensitive fiber optical parametric amplifier, enabling more than doubled reach in dispersion-managed transmission.
A novel statistical model for simulation of arterial and intracranial pressure (2005)

We describe a novel statistical model of pressure signals that incorporates the effects of respiration on arterial (ABP) and intracranial pressure (ICP). This model can be used to synthesize pulsatile ABP and ICP signals with similar time, frequency, and variability characteristics of real pressure signals. These synthetic signals can be used during the development, simulation, or quantitative assessment of biomedical algorithms in a variety of applications.
Long-term prognosis of breast cancer detected by mammography screening or other methods (2011)

Breast cancer detected by mammography screening is an independent prognostic factor in breast cancer and is associated with a more favorable survival rate as well as in long-term follow-up.
Augmented Glenoid Component for Bone Deficiency in Shoulder Arthroplasty (2008)

Asymmetric posterior glenoid wear caused by degenerative glenohumeral arthritis can be addressed by several techniques during total shoulder arthroplasty. The purpose of this study was to evaluate the midterm outcome of a posterior augmented glenoid component to determine the clinical and radiographic outcome, including complications and the need for revision surgery. Between 1995 and 1999, 13 patients (14 shoulders) underwent a shoulder arthroplasty with an augmented glenoid component to treat posterior glenoid bone deficiency. All 14 shoulders had advanced osteoarthritis. The minimum followup for these 13 patients was 2 years (mean, 5 years; range, 2-8 years). The mean age of these patients was 66 years at the time of surgery (range, 52-78 years). The mean active elevation was 160 degrees (range, 120 degrees -180 degrees ) and external rotation was 56 degrees (range, 30 degrees -90 degrees ). According to a modified Neer result rating system, 36% of patients had an excellent result, 50% a satisfactory result, and 14% an unsatisfactory result. Our results suggest patients undergoing total shoulder arthroplasty with an asymmetric glenoid component for osteoarthritis achieve satisfactory mid-term pain relief and improvement in function; however, instability is not always corrected. The advantage of this component seems marginal, and its use has been discontinued.
Supplementary Figure 3 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer (2023)

&lt;p&gt;PDF file, 153K, Cocultivated human mammary adipocytes overexpress FSP-1, but not alphaSMA, and exhibit an activated phenotype.&lt;/p&gt;
Estimating individual cone fundamentals from their color-matching functions (2016)

Estimation of individual spectral cone fundamentals from color-matching functions is a classical and longstanding problem in color science. In this paper we propose a novel method to carry out this estimation based on a linear optimization technique, employing an assumption of a priori knowledge of the retinal absorptance functions. The result is an estimation of the combined lenticular and macular filtration for an individual, along with the nine coefficients in the linear combination that relates their color-matching functions to their estimated spectral-cone fundamentals. We test the method on the individual Stiles and Burch color-matching functions and derive cone-fundamental estimations for different viewing fields and matching experiment repetition. We obtain cone-fundamental estimations that are remarkably similar to those available in the literature. This suggests that the method yields results that are close to the true fundamentals.
Protein fold recognition and dynamics in the space of contact maps (1996)

We introduce an energy function for contact maps of proteins. In addition to the standard term, that takes into account pair-wise interactions between amino acids, our potential contains a new hydrophobic energy term. Parameters of the energy function were obtained from a statistical analysis of the contact maps of known structures. The quality of our energy function was tested extensively in a variety of ways. In particular, fold recognition experiments revealed that for a fixed sequence the native map is identified correctly in an overwhelming majority of the cases tested. We succeeded in identifying the structure of some proteins that are known to pose difficulties for such tests (BPTI, spectrin, and cro-protein). In addition, many known pairs of homologous structures were correctly identified, even when the two sequences had relatively low sequence homology. We also introduced a dynamic Monte Carlo procedure in the space of contact maps, taking topological and polymeric constraints into account by restrictive dynamic rules. Various aspects of protein dynamics, including high-temperature melting and refolding, were simulated. Perspectives of application of the energy function and the method for structure checking and fold prediction are discussed.