gebhart/patrepeval huggingface dataset:
Model Linear Low Density Polyethylenes from the ROMP of 5-Hexylcyclooct-1-ene (2010)

Model hexyl-branched linear low density polyethylene (C8-LLDPE) samples were synthesized by the ring-opening metathesis copolymerization (ROMP) of the 5-hexylcyclooct-1-ene (1) and cyclooctadiene (COD), followed by catalytic hydrogenation. The ROMP of 1 and copolymerization of 1 and COD using the Grubbs second generation catalyst (G2) afford polymers with the number of hexyl branches based on the feed composition. The resulting hexyl-branched polymers, poly(1) and poly(1-stat-COD), were completely converted into model C8-LLDPE samples by catalytic hydrogenation. The C8-LLDPE samples exhibit the expected reduction in density on branching content. The melting temperature (Tm), crystallization temperature (Tc), and heat of fusion/crystallization (ΔHm/ΔHc) of these materials were studied by differential scanning calorimetry.
Supplementary Figure 4 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors (2023)

&lt;p&gt;PDF file - 941K, Characterization of E7-specific CD8+ T cell activation in tumor-bearing mice treated with radiation and intratumoral vaccination with E7 peptide.&lt;/p&gt;
Dual-Pathway Kinetics Assessment of Sulfur Poisoning of the Hydrogen Oxidation Reaction at High-Surface-Area Platinum/Vulcan Carbon Electrodes (2007)

Hydrogen oxidation reaction (HOR) kinetics were measured at films of high-surface-area platinum/Vulcan carbon (Pt/VC) exposed to aqueous solutions of mercaptopropionic acid (MPA), a water-soluble organosulfur compound, using rotating disk voltammetry. Results were fitted to a recently developed dual-pathway kinetics model. At all levels of sulfur coverage (0-96% of a monolayer of MPA), the potential-independent Tafel-Volmer pathway, or two-site HOR pathway, seems largely unaffected. Decreases in current at low overpotentials are accounted for entirely by loss in surface area of the electrode due to site occlusion by the adsorbed organosulfur. Rates for the single site, potential-dependent Heyrovsky-Volmer pathway decrease by a factor of 10 after the initial MPA exposure (50% of a monolayer), indicating an electronic effect of sulfur on the potential-dependent Heyrovsky reaction.
Optimisation and Validation of a Nutritional Intervention to Enhance Sleep Quality and Quantity (2020)

A combination of ingredients, optimised to enhance sleep, significantly reduced sleep onset latency. No detrimental effects on sleep architecture, subjective sleep quality or next day performance were observed.
In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy (2022)

The ability to observe cells in live organisms is essential for understanding their function in complex in vivo milieus. A major challenge today has been the limited ability to perform higher multiplexing beyond four to six colors to define cell subtypes in vivo. Here, a click chemistry-based strategy is presented for higher multiplexed in vivo imaging in mouse models. The method uses a scission-accelerated fluorophore exchange (SAFE), which exploits a highly efficient bioorthogonal mechanism to completely remove fluorescent signal from antibody-labeled cells in vivo. It is shown that the SAFE-intravital microscopy imaging method allows 1) in vivo staining of specific cell types in dorsal and cranial window chambers of mice, 2) complete un-staining in minutes, 3) in vivo click chemistries at lower (µm) and thus non-toxic concentrations, and 4) the ability to perform in vivo cyclic imaging. The potential utility of the method is demonstrated by 12 color imaging of immune cells in live mice.
A Novel siRNA-Based Approach to Study Mechanisms of Resistance/Action of a New Drug in Treatment of Breast Cancer. Addendum (2006)

Abstract : The mechanism by which ET-743 (YondelisTM, trabectedin) exerts its antitumor activity is not understood. The goal of this study was to study the mechanism of action/resistance of ET-743 in breast cancer cells using a novel siRNA-based approach. Two primers representing the sense and anti-sense DNA template of the random siRNA inserts were cloned into the linearized pFIV-H1/U6 siRNA expression vector. Out of 33 siRNA sequences obtained from vector transformed E.coli colonies, predicted that 67% of the siRNA template sequences would generate functional siRNA sequences and that 82% of the functional siRNA sequences were random. A pool of plasmids encoding the random siRNAs (with a possible 105 to 106different siRNAs), either transduced with pseudo- lentiviral particles or transfected with electroporation, were tested in the MCF-7 breast cancer cell line. The cell line was then treated with a lethal dose of ET-743 and cytarabine, however no resistant colonies were obtained. Further scaling-up is required to fufill the goals of this project.
Bactericidal mode of action of bedaquiline (2015)

Abstract Objectives It is not fully understood why inhibiting ATP synthesis in Mycobacterium species leads to death in non-replicating cells. We investigated the bactericidal mode of action of the anti-tubercular F1Fo-ATP synthase inhibitor bedaquiline (Sirturo™) in order to further understand the lethality of ATP synthase inhibition. Methods Mycobacterium smegmatis strains were used for all the experiments. Growth and survival during a bedaquiline challenge were performed in multiple media types. A time-course microarray was performed during initial bedaquiline challenge in minimal medium. Oxygen consumption and proton-motive force measurements were performed on whole cells and inverted membrane vesicles, respectively. Results A killing of 3 log10 cfu/mL was achieved 4-fold more quickly in minimal medium (a glycerol carbon source) versus rich medium (LB with Tween 80) during bedaquiline challenge. Assessing the accelerated killing condition, we identified a transcriptional remodelling of metabolism that was consistent with respiratory dysfunction but inconsistent with ATP depletion. In glycerol-energized cell suspensions, bedaquiline caused an immediate 2.3-fold increase in oxygen consumption. Bedaquiline collapsed the transmembrane pH gradient, but not the membrane potential, in a dose-dependent manner. Both these effects were dependent on binding to the F1Fo-ATP synthase. Conclusions Challenge with bedaquiline results in an electroneutral uncoupling of respiration-driven ATP synthesis. This may be a determinant of the bactericidal effects of bedaquiline, while ATP depletion may be a determinant of its delayed onset of killing. We propose that bedaquiline binds to and perturbs the a-c subunit interface of the Fo, leading to futile proton cycling, which is known to be lethal to mycobacteria.
Optical properties of arsenic ions implanted GaAs/AlGaAs V-grooved quantum wires (2000)

Asymmetric double GaAs/AlGaAs V-grooved quantum wires, grown by low pressure metalorganic chemical vapor deposition, are studied using photoluminescence (PL) spectroscopy. The structure was selectively treated by ion implantation at different arsenic (As) doses after growth. The ion implantation strongly reduces the efficiency of the emissions from the implanted well regions or even quenches the PL emissions from certain well regions due to irradiation damage. Wire emission is clearly resolved in the samples after treatment by low dose implantation. The temperature dependence of the wire emission intensity shows an enhancement at a temperature of around 45 K. The wire emission peak with a shoulder at its high energy side at low temperatures develops into double peaks in a temperature region between 20 and 140 K, and the high energy transition component dominates the PL spectra at temperatures above 140 K. The deduced energy separation between two peaks is about 10 meV. With further increasing temperatures the wire emission related to the light hole state can be observed at temperatures above 150 K. Deduced splitting between the heavy and light states is about 35 meV in our structures.
Expansion of the Gene Ontology knowledgebase and resources (2016)

The Gene Ontology (GO) is a comprehensive resource of computable knowledge regarding the functions of genes and gene products. As such, it is extensively used by the biomedical research community for the analysis of -omics and related data. Our continued focus is on improving the quality and utility of the GO resources, and we welcome and encourage input from researchers in all areas of biology. In this update, we summarize the current contents of the GO knowledgebase, and present several new features and improvements that have been made to the ontology, the annotations and the tools. Among the highlights are 1) developments that facilitate access to, and application of, the GO knowledgebase, and 2) extensions to the resource as well as increasing support for descriptions of causal models of biological systems and network biology. To learn more, visit http://geneontology.org/.
Periodic‐Current‐Modulation Effects in Alkaline and Acidic Electrodeposition of Zinc (1991)

The effect of alternating voltage, pulse reverse voltage, and pulse reverse current, on the electrodeposition of zinc is investigated using a rotating disk electrode of carbon. The effect on deposition from an alkaline solution, in respect to polarization and deposit morphology, is compared to that in an acidic solution. In both types of solution, alternating voltage and pulse reverse voltage produce finer grained deposits, probably due to higher nucleation rates. Polarization is also reduced in both types of solutions but to different extents, indicating dominance of mass transfer resistance in alkaline deposition and of ohmic resistance in acidic deposition. Current inefficiency (hydrogen evolution) in pulse reverse current deposition from acidic solution is compared with that at constant voltage. Reduced hydrogen evolution appears to play an important role in the change of morphology to finer‐grained deposits.
Mixing (2010)

No AccessUnderstanding Polymer ProcessingOct 2010MixingTim A. OsswaldTim A. Osswaldhttps://doi.org/10.3139/9783446446038.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2010Pages: 91-109Print ISBN: 978-3-446-42404-3eISBN: 978-3-446-44603-8 Copyright & Permissions© 2011 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Molecular-dynamics model of energetic fluorocarbon-ion bombardment on SiO2 I. Basic model and CF2+-ion etch characterization (2005)

A molecular-dynamics-based model has been developed to understand etching of amorphous SiO2, with and without a fluorocarbon reactive layer, by energetic fluorocarbon (CFx+) ions. The model includes a representation of the solid and a set of interatomic potentials required for the SiO2–CFx interaction system. Two- and three-body pseudopotentials have either been obtained from published literature or computed using ab initio techniques. The Stillinger–Weber potential construct is used to represent potentials in our model and particle trajectories are advanced using the velocity-Verlet algorithm. The model is validated by comparing computed bond lengths and energies with published experimental results. Computed yield for Ar+ ion sputtering of SiO2 is also compared with published data. In the computational results described in this article, the model SiO2 test structure (with a thin fluorocarbon reactive layer) is prepared by starting with α-quartz ([001] orientation) and bombarding it with 50-eV CF2+ ions. Energetic CF2+ ions with different energies and angles of impact are then bombarded on this test structure to determine ion etch characteristics. Results show that etch yield increases with ion energy for all angles of impact. Etch yield, however, exhibits a nonlinear dependence on angle of impact with a peak around 60°. This nonlinear behavior is attributed to the balance among fraction of incident ion energy deposited in the material, ion energy deposition depth, and direction of scattering during secondary interaction events. Si in the lattice is primarily etched by F atoms and the primary Si-containing etch by-products are SiFx and SiOxFy radicals. However, oxygen either leaves the test structure as atomic O or in combination with C. While fragments of the energetic incident ion retain a substantial fraction of incident ion energy on ejection from the surface, etch by-products that have their origin in test structure atoms only have a few eV of energy on exit. Etch results are sensitive to fluorocarbon layer characteristics and etch yields decrease as the fluorocarbon reactive layer thickens.
Study of Stochastic Invertible Multiplier Designs (2018)

Invertible logic is a method of reversible computing that can propagate a circuit signal backward from outputs. For example, not only multiplication (forward operation) but also division and factorization (backward operation) can be performed by this circuit style of a single multiplier. Currently, invertible logic has been able to realize only small-scale circuits. In this paper, we design larger-scale circuits than that reported conventionally, using stochastic computing. Furthermore, we also verify the performance of invertible logic using three different multipliers.
Phase variation in meningococcal lipooligosaccharide biosynthesis genes (2002)

Neisseria meningitidis expresses a range of lipooligosaccharide (LOS) structures, comprising of at least 13 immunotypes (ITs). Meningococcal LOS is subject to phase variation of its terminal structures allowing switching between ITs, which is proposed to have functional significance in disease. The objectives of this study were to investigate the repertoire of structures that can be expressed in clinical isolates, and to examine the role of phase-variable expression of LOS genes during invasive disease. Southern blotting was used to detect the presence of LOS biosynthetic genes in two collections of meningococci, a global set of strains previously assigned to lineages of greater or lesser virulence, and a collection of local clinical isolates which included paired throat and blood isolates from individual patients. Where the phase-variable genes lgtA, lgtC or lgtG were identified, they were amplified by PCR and the homopolymeric tracts, responsible for their phase-variable expression, were sequenced. The results revealed great potential for variation between alternate LOS structures in the isolates studied, with most strains capable of expressing several alternative terminal structures. The structures predicted to be currently expressed by the genotype of the strains agreed well with conventional immunotyping. No correlation was observed between the structural repertoire and virulence of the isolate. Based on the potential for LOS phase variation in the clinical collection and observations with the paired patient isolates, our data suggest that phase variation of LOS structures is not required for translocation between distinct compartments in the host.
Propagation velocity of the reaction front in addition polymerization systems (1997)

Traveling polymerization fronts in unstirred solutions of methylmethacrylate, methacrylic acid, or acrylamide with some free radicals initiators (through thermal decomposition) have been observed experimentally. A local heating of the initial reactant mixture, under suitable conditions, leads to a reaction front that propagates along the space coordinate with a constant velocity. In this article, a physical interpretation of this phenomenon is provided through a mathematical model that accounts for the depolimerization reaction and is based on the constant pattern approach. Moreover, an approximate explicit analytic expression for the velocity of propagation of the polymerization front is proposed. The theoretical values are compared with those measured experimentally as a function of the initiator concentration for different addition polymerization systems. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35:1047–1059, 1997
Controlled release of contraceptive steroids from biodegradable poly (ortho esters). (1983)

The synthesis of poly (ortho esters) by the condensation of diols and diketene acetals and the in vitro drug release from devices containing norethindrone or levonorgestrel and either Na2C03 or Na2S04 is described. Drug release kinetics are rationalized in terms of an osmotically driven water imbibition and release of the steroid from the swollen polymer. No polymer erosion occurs when Na2C03 is used. When Na2S04 is used, polymer erosion does take place but lags drug release. As expected from the known acid lability of ortho ester linkages, drug release is strongly dependent on the pH of the external environment and a dramatic increase occurs between pH 5.5 and 5.0. The glass transition temperature of the poly (ortho esters) can be continuously and predictably varied between 115 and 20 degrees Celsius by using an appropriate ratio of 1,6-hexanediol, and trans-cyclohexanedimethanol in the condensation reaction with the diketene acetal. Polymer hydrophilicity can be varied by the incorporation of varying amounts of the hydrophilic diol diethylene glycol into the polymer. Molecular weight control can be readily achieved by skewing the stoichiometry, and polymers with weight average molecular weights between 20,000 and in excess of 100,000 have been produced. Hydrolytic degradation of the poly (ortho esters) produces the expected products.
Traffic-Aware Scheduling and Feedback Allocation in Multichannel Wireless Networks (2018)

This paper studies the problem of feedback allocation and scheduling for a multichannel downlink cellular network under limited and delayed feedback. We propose two efficient algorithms that select the link states that should be reported to the base station (BS). A novelty here is that these feedback allocation algorithms are performed at the users' side to take advantage of their local channel state information knowledge in order to achieve higher gains. The first algorithm is suitable for a continuous-time contention scheme and requires only one feedback per channel, whereas the second one is adapted for a discrete-time contention scheme and adopts a threshold-based concept. For this second algorithm, we study some implementation aspects related to the feedback period and investigate the tradeoff between knowing at the BS a small number of accurate link states and a larger but outdated number of link states. We show that these algorithms, combined with the Max-Weight scheduling, achieve good stability performance compared with the ideal system.
Supplementary Data from CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells (2023)

&lt;p&gt;Supplementary Figures S1-S8 S1 Heat map of chemokines and receptors S2 Immunohistochemical staining of lymphatic vessels S3 Expression of VEGF-D and chemokines in cancer cell lines S4 Expression of genes in melanoma patient samples S5 Chemokine secretion by tumour cells S6 Chemokine induced migration of LEC S7 Chemokines attract LEC in vivo S8 CCL-293EBNA tumour growth and CCL27 secretion&lt;/p&gt;
Photodegradation of rhodamine B over semiconductor supported gold nanoparticles: The effect of semiconductor support identity (2014)

Rhodamine B (RB) is a toxic dye used extensively in textile industry, which must be remediated before its drainage to environment. In the present study, supported gold nanoparticles on commercially available titania and zincite were successfully prepared and then their activity on the photodegradation of RB under UV A light irradiation was evaluated. The synthesized photocatalysts were characterized by ICP, BET, XRD, TEM and EDX. Kinetic results showed that Au/TiO2 was a photocatalyst inferior to Au/ZnO. This observation could be attributed to the strong reflection of UV irradiation by gold nanoparticles over TiO2 support.
Starburst Type Benzofuroindolocarbazole Donor for High Efficiency and Long Lifetime in Thermally Activated Delayed Fluorescence Emitters (2020)

Abstract A series of thermally activated delayed fluorescence (TADF) emitters of 5‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)‐2‐(15‐phenylbenzofuro[3,2‐ a ]indolo[3,2‐ c ]carbazol‐10(15 H )‐yl)benzonitrile (TrzCNTrx1) and 5‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)‐2‐(10‐phenylbenzofuro[3,2‐ a ]indolo[3,2‐ c ]carbazol‐15(10 H )‐yl)benzonitrile (TrzCNTrx2) are developed through a molecular design strategy that incorporates a starburst type benzofuro[3,2‐ a ]indolo[3,2‐ c ]carbazole as a rigid donor. The benzofuro[3,2‐ a ]indolo[3,2‐ c ]carbazole is developed as a strong and rigid donor for strong charge transfer character in the TADF emitter in combination with a diphenyltriazine acceptor and a benzonitrile linker. Two starburst type donors with different active sites for the aromatic linker substitution are prepared. Among the TrzCNTrx1 and TrzCNTrx2 emitters, the TrzCNTrx2 emitter shows a small singlet–triplet energy gap below 0.10 eV, high photoluminescence quantum yields over 90%, and short exciton lifetimes less than 5.0 µs. In the device application, the TrzCNTrx2 emitter shows maximum external quantum efficiency of 20.6% with little efficiency roll‐off less than 2% at 3000 cd m −2 and color coordinate of (0.37, 0.57). Moreover, the TrzCNTrx2 device is much better than the TrzCNTrx1 in terms of device lifetime because of short delayed fluorescence lifetime.
N‐face high electron mobility transistors with a GaN‐spacer (2007)

Abstract N‐face AlGaN (cap)/GaN (channel)/AlGaN (barrier)/GaN (buffer) high electron mobility transistors (HEMTs) provide a simple solution for strong confinement of the two‐dimensional electron gas (2DEG) from the back since carriers are induced on top of the AlGaN barrier. To reduce the adverse effects of random alloy scattering from the AlGaN barrier, an N‐face GaN‐spacer HEMT was designed with an epi‐structure consisting of an AlGaN (cap)/GaN (channel)/AlN/GaN (spacer)/AlGaN (barrier)/GaN (buffer). The 2DEG is confined at the GaN (channel)/AlN interface, while the GaN‐spacer layer separates the 2DEG from the AlGaN barrier. The large polarization‐induced electric field of the AlN and its large conduction band discontinuity with GaN provide strong confinement for good pinch‐off and low output conductance under high electric fields. Up to 20% improvement in electron mobility was measured in these devices. The devices showed a current gain cut‐off frequency ( f t ) of 24 GHz and power gain cut‐off frequency ( f max ) of 44 GHz for a nominal gate length of 0.7 μm. An output power density of 4.5 W/mm was measured at 4 GHz, with 34% power added efficiency and a gain of 10.3 dB at a drain bias of 40 V. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Integrating RJMCMC and Kalman filters for multiple object tracking (2015)

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