gebhart/patrepeval huggingface dataset:
Cloud-RAN Modeling Based on Parallel Processing (2018)

We consider in this paper the implementation of a cloud radio access network (C-RAN) on a centralized multicore system supporting the base band processing of several distributed antennas. We present a parallel processing model based on both functional and data decomposition of virtualized base band unit (BBU) functions in order to reduce their runtime. We study two scheduling strategies of parallel runnable BBU jobs, where computing resources can be allocated either per user equipments or else per code blocks. By using data obtained when running an open source RAN code (namely, OAI), we introduce a batch queuing model (the M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[X ]</sup> /M/C multi-service system) to assess the needed processing capacity in a data center while meeting tight latency requirements in the down-link and up-link directions. The proposed model is validated by simulation when processing a hundred LTE-cells in a multi-core system. Results provide valuable guidelines for sizing and deploying Cloud-RAN systems.
Supplementary Table 1 from AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with <i>In vitro</i> and <i>In vivo</i> Antitumor Activity (2023)

Supplementary Table 1 from AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; Antitumor Activity
Photolithographic processing of hybrid glasses for microoptics (2003)

Hybrid glass materials are used in the photolithographic fabrication of optical and optomechanical structures. Two different photolithographic hybrid glass processing methods are described. The first one is referred as photolithographic patterning and the second as direct photolithographic deforming of hybrid glass materials. No etch transfer of the photoimaged structures is needed. In the latter method even the chemical development step can be excluded from the fabrication. Fabrication of lens-arrays, gratings and other binary structures is presented. The synthesized hybrid glass materials feature minimum optical transmission of 97% at wavelengths ranging from 450 nm to 1600 nm and refractive index of, e.g., 1.53 at 632.8 nm. The photolithographic patterning resulted in structure heights in excess of 180 μm with rms surface roughness values ranging from 10 to 45 nm. The direct photolithographic deforming resulted in structure heights in excess of 27 μm with rms surface roughness values ranging from 1 and 15 nm.
Correction (1999)

Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice ...Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance. However, the underlying biology of SAD is unclear and better treatments are needed. Recently, the gut ...
The Synthesis and Biological Evaluation of N‐Substituted 1H‐Benzimidazol‐2‐yl‐1H‐pyrazole‐3,5‐diamines (2015)

The synthesis of 1 H ‐benzimidazol‐2‐yl‐1 H ‐pyrazole‐3,5‐diamines has been developed. Synthesized bisheteroaryls contain two privileged medicinal scaffolds, aminopyrazole and benzimidazole, with two diversity positions at N1 of benzimidazole and C3 of pyrazole, respectively. The three‐step synthesis includes the Mitsunobu N ‐alkylation of benzimidazole and subsequent one‐pot formation of aminopyrazole involving substitution of methylthio groups with amine and hydrazine followed with final ring closure. Inhibitory activity toward cyclin‐dependent kinase 2/cyclin E and cytotoxicity against two cancer cell lines were evaluated for all novel pyrazoles. Two compounds showed modest cyclin‐dependent kinase inhibition activity and cytotoxicity against cancer cell lines K562 and MCF7.
Spatial and feature normalization for content-based retrieval (2003)

We explore methods for spatial and feature normalization of visual descriptors for content-based retrieval (CBR). A great many descriptors have been developed for characterizing features such as color, texture, edges, and so forth. In addition, numerous methods have also been proposed for extracting descriptors from whole images or regions. Furthermore, different options are possible for normalizing descriptor values for matching. We study different spatial and feature normalization strategies that include extracting descriptors from different spatial partitionings and normalizing descriptor values based on metric-space considerations or statistics of image collections. We empirically evaluate the relative efficacy in an image retrieval testbed.
Effects of TRPA1 agonists on murine airways (2016)

TRPA1 is a cation channel of the transient receptor potential channel family that is predominantly expressed in sensory C-fibers and activated by a wide variety of environmental irritants and endogenous inflammatory mediators relevant for asthma. Activation increases [Ca2+]i, induces inward currents and action potential discharge in lunginnervating C-fibers in vitro and elicits central reflexes in vivo. However, it remained unclear if TRPA1-dependent central reflex activity is associated with changes in lung function. To examine our hypothesis that TRPA1 activation in C-fibers induces bronchoconstriction, we performed head-out-bodyplethysmography in conscious mice and measured the midexpiratory tidal flow (EF50) during inhalation of increasing concentrations of cinnamaldehyde (CA), a TRPA1 agonist. Unexpectedly, CA induced a dose-dependent increase of EF50, characteristic for bronchodilation. Organ bath experiments were performed by using explanted, preconstricted tracheal rings to elucidate the nature of bronchodilation. Our results revealed that the CA effect was independent from central reflexes and could be mimicked by a variety of electrophilic and non-electrophilic TRPA1 agonists, including arcrolein, AITC, 2-APB, thymol and carvacrol. Surprisingly, the bronchodilatory effect of CA was increased by pre-treatment with TRPA1-antagonists (HC-030031, AP-18, Ruthenium-Red) as well as in tracheas of TRPA1-KO mice, indicating that CA causes a TRPA1-mediated bronchoconstriction which is superimposed by a TRPA1-independent bronchodilation. Since a 5-day organotypic culture of the tracheas or pretreatment by RP-67580, a neurokinin 1 receptor (NK1R) antagonist, respectively, was associated with an increased bronchodilation, we conclude that the TRPA1-dependent bronchoconstriction involves sensory neurons and is dependent on NK1R signalling. However, the nature of the TRPA1-independent bronchodilation remains unclear since iberiotoxin, indomethacin, tetrodotoxin, propranolol, Nω-nitro-L-arginine and triphenylphosphine-oxide were ineffective. We conclude that activation of TRPA1 in C-fibers induces bronchoconstriction superimposed by a bronchodilatory effect of unknown etiology.
Complex Equilibria, Speciation, and Heteroprotein Coacervation of Lactoferrin and β-Lactoglobulin (2015)

There has been a resurgence of interest in complex coacervation, a form of liquid-liquid phase separation (LLPS) in systems of oppositely charged macroions, but very few reports describe the somewhat anomalous coacervation between acidic and basic proteins, which occurs under very narrow ranges of conditions. We sought to identify the roles of equilibrium interprotein complexes during the coacervation of β-lactoglobulin dimer (BLG2) with lactoferrin (LF) and found that this LLPS arises specifically from LF(BLG2)2. We followed the progress of complexation and coacervation as a function of r, the LF/BLG molar ratio, using turbidity to monitor the degree of coacervation and proton release and dynamic light scattering (DLS) to assess the stoichiometry and abundance of complexes. Isothermal titration calorimetry (ITC) showed that initial complex formation is endothermic, but a large exotherm related to coacervate formation obscured other regions. On the basis of turbidimetry, proton release, and DLS, we propose a speciation diagram that presents the abundance of various complexes as a function of r. Although multiple species could be simultaneously present, distinct regions could be identified corresponding to equilibria among particular protein pairs.
Molybdän‐ und Wolframimidoalkylidenkomplexe als effiziente Olefinmetathesekatalysatoren (2003)

Abstract Die katalytische Olefinmetathese hat sich schnell zu einer der am häufigsten eingesetzten Transformationen der modernen chemischen Synthese entwickelt. Ein Klasse von Katalysatoren, die den Weg zu dieser bedeutenden Entwicklung wiesen, sind die hochoxidierten Alkylidenkomplexe des Molybdäns. Dieser Aufsatz umreißt entscheidende Beobachtungen, die zur Entdeckung und Entwicklung von Molybdän‐ und Wolfram‐Metathesekatalysatoren führten. Schwerpunktmäßig beschrieben wird der Einsatz von Molybdänkatalysatoren in der Synthese biologisch relevanter Verbindungen und die Verwendung von chiralen Molybdänkomplexen zur enantioselektiven Synthese. Derartige hocheffiziente Katalysatoren eröffnen einen einzigartigen Zugang zu Materialien von außergewöhnlicher Enantiomerenreinheit, häufig unter Vermeidung von Lösungsmittelabfällen.
EBSD coupled to SEM in situ annealing for assessing recrystallization and grain growth mechanisms in pure tantalum (2013)

An in situ annealing stage has been developed in-house and integrated in the chamber of a Scanning Electron Microscope equipped with an Electron BackScattered Diffraction system. Based on the Joule effect, this device can reach the temperature of 1200°C at heating rates up to 100°C/s, avoiding microstructural evolutions during heating. A high-purity tantalum deformed sample has been annealed at variable temperature in the range 750°C-1030°C, and classical mechanisms of microstructural evolutions such as recrystallization and grain coarsening phenomena have been observed. Quantitative measurements of grain growth rates provide an estimate of the mean grain boundary mobility, which is consistent with the value estimated from physical parameters reported for that material. In situ annealing therefore appears to be suited for complementing bulk measurements at relatively high temperatures, in the context of recrystallization and grain growth in such a single-phase material.
Efficient Electronic Tunneling Governs Transport in Conducting Polymer-Insulator Blends (2022)

Electronic transport models for conducting polymers (CPs) and blends focus on the arrangement of conjugated chains, while the contributions of the nominally insulating components to transport are largely ignored. In this work, an archetypal CP blend is used to demonstrate that the chemical structure of the non-conductive component has a substantial effect on charge carrier mobility. Upon diluting a CP with excess insulator, blends with as high as 97.4 wt % insulator can display carrier mobilities comparable to some pure CPs such as polyaniline and low regioregularity P3HT. In this work, we develop a single, multiscale transport model based on the microstructure of the CP blends, which describes the transport properties for all dilutions tested. The results show that the high carrier mobility of primarily insulator blends results from the inclusion of aromatic rings, which facilitate long-range tunneling (up to <i>ca.</i> 3 nm) between isolated CP chains. This tunneling mechanism calls into question the current paradigm used to design CPs, where the solubilizing or ionically conducting component is considered electronically inert. Indeed, optimizing the participation of the nominally insulating component in electronic transport may lead to enhanced electronic mobility and overall better performance in CPs.
Evaluation of combined visible/NIR camera for iris authentication on smartphones (2015)

Iris biometrics provide a mature and robust method of authentication, but are typically applied in a controlled environment and under constrained acquisition conditions. In this paper, the adaption of iris biometrics for unconstrained, hand-held use cases such as smartphones is investigated. A prototype optics-sensor combination is analysed in terms of its optical properties and iris imaging capabilities. The corresponding camera system with dual visible/NIR sensing capabilities and 4 Megapixel resolution is tested for suitability to implement iris recognition on smartphones. Recognition performance is analysed together with image quality comparisons. Preliminary results indicate that there are challenges to achieve reliable recognition performance in unconstrained use cases. Current optical systems are not diffraction limited, particularly at NIR wavelengths; pixel resolutions are close to the useful limits for iris recognition and acquisition conditions are challenging. Nevertheless, our findings indicate a similar camera module, with an improved optics and sensor, could combine biometric authentication with more conventional front-camera functions such as the capture of selfie images.
CCDC 112056: Experimental Crystal Structure Determination (2000)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Adaptación de la materia de Análisis Numérico a la docencia de Ingeniería Informática en el Espacio Europeo de Educación Superior (2010)

El objetivo de este trabajo es analizar las deficiencias actuales en la docencia de la materia de Analisis Numerico, asi como avanzar en la propuesta de una metodologia adecuada a los nuevos retos docentes impuestos por la creacion del Espacio Europeo de Educacion Superior. Se pretende lograr la estructura requerida, al tiempo que aumentar la participacion activa del alumno en su formacion. El estudio, realizado sobre la base proporcionada por la docencia de la materia en la Facultad de Informatica de la Universidad Politecnica de Madrid, es extrapolable a otros centros docentes y titulaciones de similares caracteristicas.
Interactive Visual Analysis of Transcribed Multi-Party Discourse (2017)

We present the first web-based Visual Analytics framework for the analysis of multi-party discourse data using verbatim text transcripts. Our framework supports a broad range of server-based processing steps, ranging from data mining and statistical analysis to deep linguistic parsing of English and German. On the client-side, browser-based Visual Analytics components enable multiple perspectives on the analyzed data. These interactive visualizations allow exploratory content analysis, argumentation pattern review and speaker interaction modeling.
The added value of joint PP–PS inversion for reservoir characterization: A case study using Jubarte PRM seismic data (offshore Brazil) (2021)

ABSTRACT The added value of the joint pre‐stack inversion of PP (incident P‐wave and reflected P‐wave) and PS (incident P‐wave and reflected S‐wave) seismic data for the time‐lapse application is shown. We focus on the application of this technique to the time‐lapse (four‐dimensional) multicomponent Jubarte field permanent reservoir monitoring seismic data. The joint inversion results are less sensitive to noise in the input data and show a better match with the rock physics models calibrated for the field. Further, joint inversion improves S‐impedance estimates and provides a more robust quantitative interpretation, allowing enhanced differentiation between pore pressure and fluid saturation changes, which will be extremely useful for reservoir management. Small changes in reservoir properties are expected in the short time between the time‐lapse seismic acquisitions used in the Jubarte project (only 1 year apart). The attempt to recover subtle fourth‐dimensional effects via elastic inversion is recurrent in reservoir characterization projects, either due to the small sensitivity of the reservoirs to fluid and pressure changes or the short interval between the acquisitions. Therefore, looking for methodologies that minimize the uncertainty of fourth‐dimensional inversion outputs is of fundamental importance. Here, we also show the differences between PP only and joint PP–PS inversion workflows and parameterizations that can be applied in other projects. We show the impact of using multicomponent data as input for elastic seismic inversions in the analysis of the time‐lapse differences of the elastic properties. The larger investment in the acquisition and processing of multicomponent seismic data is shown to be justified by the improved results from the fourth‐dimensional joint inversion.
NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination (2007)

Neurons and glia share a mutual dependence in establishing a functional relationship, and none is more evident than the process by which axons control myelination. Here, we identify LRR and Ig domain-containing, Nogo receptor-interacting protein (LINGO-1) as a potent axonal inhibitor of oligodendrocyte differentiation and myelination that is regulated by nerve growth factor and its cognate receptor TrkA in a dose-dependent manner. Whereas LINGO-1 expressed by oligodendrocyte progenitor cells was previously identified as an inhibitor of differentiation, we demonstrate that axonal expression of LINGO-1 inhibits differentiation with equal potency. Disruption of LINGO-1 on either cell type is sufficient to overcome the inhibitory action and promote differentiation and myelination, independent of axon diameter. Furthermore, these results were recapitulated in transgenic mice overexpressing the full length LINGO-1 under the neuronal promoter synapsin. Myelination was greatly inhibited in the presence of enforced axonal LINGO-1. The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development.
Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation (2007)

Immunosuppressive drugs can be completely withdrawn in up to 20% of liver transplant recipients, commonly referred to as 'operationally' tolerant. Immune characterization of these patients, however, has not been performed in detail, and we lack tests capable of identifying tolerant patients among recipients receiving maintenance immunosuppression. In the current study we have analyzed a variety of biological traits in peripheral blood of operationally tolerant liver recipients in an attempt to define a multiparameter 'fingerprint' of tolerance. Thus, we have performed peripheral blood gene expression profiling and extensive blood cell immunophenotyping on 16 operationally tolerant liver recipients, 16 recipients requiring on-going immunosuppressive therapy, and 10 healthy individuals. Microarray profiling identified a gene expression signature that could discriminate tolerant recipients from immunosuppression-dependent patients with high accuracy. This signature included genes encoding for gammadelta T-cell and NK receptors, and for proteins involved in cell proliferation arrest. In addition, tolerant recipients exhibited significantly greater numbers of circulating potentially regulatory T-cell subsets (CD4+ CD25+ T-cells and Vdelta1+ T cells) than either non-tolerant patients or healthy individuals. Our data provide novel mechanistic insight on liver allograft operational tolerance, and constitute a first step in the search for a non-invasive diagnostic signature capable of predicting tolerance before undergoing drug weaning.
Plasmon light scattering of a single gold nanoparticle attached to a single mode optical fiber tip (2004)

Single gold nanoparticle was attached to a single mode optical fiber tip by picking it up from the glass surface. Plasmon scattering from the absorbed nanoparticle was detected through the optical fiber in various solution environments.
Light along curves: photonic shaping tools (2023)

A structured light concept is reported enabling to distribute a large number of focus copies at arbitrary positions in a working volume. Applying this holographic 3D-beam splitter concept to ultrashort laser pulses allows to deposit energy along accelerating trajectories in the volume of transparent materials. Based on the entirety of the volume modifications created in this way, the material can be separated, for example, to create chamfered glass edges. These photonic tools impress with enormous versatility, which enable equally diverse application strategies ranging from cutting and welding to data storing.
Geostationary satellite‐based 6.7 μm band best water vapor information layer analysis over the Tibetan Plateau (2016)

Abstract The best water vapor information layer (BWIL) of the 6.7 μm water vapor absorption infrared (IR) band for the FengYun‐2E is investigated over the Tibetan Plateau with standard atmospheric profile and European Centre for Medium‐Range Weather Forecasts (ECMWF) operational model analysis data. The sensitivity tests show that surface characteristics over the Tibetan Plateau have a significant influence on the BWIL. To be specific, topographic elevation, colder skin temperature, and lower emissivity tend to lift the altitude of the BWIL, decrease its magnitude, and narrow the half‐width range. The results from statistical analysis indicate that the altitude of the BWIL reaches the highest in summer and the lowest in winter. Meanwhile, the altitude of the BWIL is highly correlated with the water vapor amount above 500 hPa over the Tibetan Plateau and above 300 hPa over the East China Plain, respectively. The diurnal variation in the BWIL is synchronous with the diurnal variation in the surface skin temperature. It can be concluded from the study that surface characteristics over high terrain in dry and cold atmospheres have more significant impacts on the BWIL. With multiple water vapor absorption IR bands, the imagers on board the new generation of geostationary satellites will provide crucial improvement in water vapor remote sensing over the current single water vapor band on board the FY‐2 series according to the analysis in this study.
Model Based Control System Design and Verification for a Hybrid Electric Vehicle (2003)

&lt;div class="htmlview paragraph"&gt;A hybrid electric vehicle requires a complex control system to effectively manage vehicle level attributes while maximizing fuel efficiency. The control system interactions necessitate a hierarchical control structure in which one controller, the vehicle system controller, directs the functions of the lower level controllers. This paper outlines a model-based method that allows a controls team to design and validate a vehicle system controller for use in a hybrid electric vehicle.&lt;/div&gt;