gebhart/patrepeval huggingface dataset:
Rapid selective dimerization of ethylene to 1-butene by a tantalum catalyst and a new mechanism for ethylene oligomerization (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid selective dimerization of ethylene to 1-butene by a tantalum catalyst and a new mechanism for ethylene oligomerizationJere D. Fellmann, Gregory A. Rupprecht, and Richard R. SchrockCite this: J. Am. Chem. Soc. 1979, 101, 17, 5099–5101Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://doi.org/10.1021/ja00511a067RIGHTS & PERMISSIONSArticle Views371Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (458 KB) Get e-Alerts Get e-Alerts
Superresolved Imaging of Microelectronic Devices for Improved Failure Analysis (2009)

In this paper, we present a new numerical approach for improving the resolving power of low-resolution (LR) images. This approach may be applied for failure analysis of microelectronic chips. The resolution improvement is based upon numerical iterative comparison between a LR experimentally captured image and a high-resolution layout image of the same region of interest.
EQ Coating: A New Concept for SRZ-Free Coating Systems (2008)

Ni-base single crystal (SC) superalloys with high concentrations of refractory elements prone to generate a diffusion layer called Secondary Reaction Zone (SRZ) beneath their bond coating during long time exposure at high temperatures. SRZ causes a reduction of the load bearing cross section and it is detrimental to the creep properties of thin-wall turbine airfoils. In this study, a new bond coat system, "EQ coating" which is thermodynamically stable and suppresses SRZ has been proposed. Diffusion couples of coating materials and substrate alloys were made and were heat treated at 1100C for 300h and 1000h. Cyclic oxidation examinations were carried out at 1100C in air and the oxidation properties of EQ coating materials were discussed. High velocity frame sprayed (HVOF) EQ coatings designed for 2 nd generation Ni-base superalloy were deposited on 4 th generation Ni-base superalloys. The stability of microstructure at the interface and creep property of the coating system were investigated. Less than 50m-thick of the interdiffusion zone and no SRZ were observed in EQ coating system after 300h heat treatment at 1100C, in contrast to beyond 90m-thick of diffusion zone and 140m-thick of SRZ in the conventional CoNiCrAlY coating system. Creep strength of Al-diffusion and CoNiCrAlY coated 4 th generation superalloys showed decrease in thin creep specimens, but EQ coated 4 th generation superalloy showed equivalent creep strength for bare material.
Fluoropolymer resists for 157 nm lithography (2003)

Fluoropolymers have been shown to be one of the best materials for high transparency of 157 nm wavelength radiation. Both resists and pellicles are being designed from such materials. One of our approaches to improved transparency for 157 nm resists is based upon fluorinated variations of polymethacrylate and polyhydroxystyrene derivatives. Lithographic studies were carried out on experimental resist platforms using 157 nm and 248 nm steppers, and it was shown that, after selective modification, it is possible to use conventional resist backbones, such as acrylic or styrenic, in the design of single-layer resists for 157 nm lithography. It has been demonstrated in our studies that 157 nm absorbance of these materials can be as low as 1.5-2.0&#956;m<sup>-1</sup>. Another approach to 157 nm resist design is based upon fluorinated backbone variations. Research will be described focusing on several new monomers having fluorine functions such as -F and -CF<sub>3</sub> groups near a polymerizable double bond to improve transparency at 157 nm and to raise the resist glass transition temperature compared to their hydrocarbon analogues. Due to the lower electron density of the double bond, these monomers can be copolymerized with electron-rich vinyl monomers. As an extension to this strategy, we are synthesizing novel fluoropolymers having partially fluorinated monocyclic structures with radical cyclo-polymerization. These polymers have the C-F bond on the polymer main chain and also possess acid labile groups as part of a ring structure to eliminate degassing. In order to further enhance the transparency of these systolic polymers at 157 nm, we have eliminated the carbonyl group. The cyclic nature of the polymer will result in a high glass transition temperature.
Building and Operating a Large-Scale Enterprise Data Analytics Platform (2020)

Over the last three years we have been running a large-scale data processing platform for applying analytics to corporate data at scale on an OpenStack private cloud instance. Our platform makes a wide variety of corporate data assets, such as sales, marketing, customer information, as well as data from less conventional sources such as weather, news and social media available for analytics purposes to hundreds of globally distributed teams across the company. We control every layer in the stack from the processing engines down to the hardware. Here we report our experiences in building and operating such a system. We describe our technical choices and describe how they evolved as we observed the actual workloads created by users.
Integrated Bragg gratings in spiral waveguides (2013)

Over the last two decades, many filters requiring custom spectral responses were obtained from photo-inscribed fiber Bragg gratings because of the flexibility inherent to this technology. However, Bragg gratings in silicon waveguides have the potential to provide faster and more efficient tuning capabilities when compared to optical fiber devices. One drawback is that Bragg gratings filters with elaborate spectral amplitude and phase responses often require a long interaction length, which is not compatible with current integration trends in CMOS compatible photonic circuits. In this paper, we propose to make Bragg gratings in spiral-shaped waveguides in order to increase their lengths while making them more compact. The approach preserves the flexibility of regular straight grating structures. More specifically, we demonstrate 2-mm long gratings wrapped in an area of 200 µm x 190 µm without any spectral degradation due to waveguide curvature. Furthermore, we interleave three spiral waveguides with integrated gratings thereby tripling the density and demonstrate good phase compensation for each of them. Finally, we show that this approach is compatible with phase-apodization of the grating coupling coefficient.
Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography−tandem mass spectrometry (2019)

Kratom (Mitragyna speciosa) is a psychoactive plant popular in the United States for the self-treatment of pain and opioid addiction. For standardization and quality control of raw and commercial kratom products, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of ten key alkaloids, namely: corynantheidine, corynoxine, corynoxine B, 7-hydroxymitragynine, isocorynantheidine, mitragynine, mitraphylline, paynantheine, speciociliatine, and speciogynine. Chromatographic separation of diastereomers, or alkaloids sharing same ion transitions, was achieved on an Acquity BEH C18 column with a gradient elution using a mobile phase containing acetonitrile and aqueous ammonium acetate buffer (10mM, pH 3.5). The developed method was linear over a concentration range of 1-200 ng/mL for each alkaloid. The total analysis time per sample was 22.5 minutes. The analytical method was validated for accuracy, precision, robustness, and stability. After successful validation, the method was applied for the quantification of kratom alkaloids in alkaloid-rich fractions, ethanolic extracts, lyophilized teas, and commercial products. Mitragynine (0.7%-38.7% w/w), paynantheine (0.3%-12.8% w/w), speciociliatine (0.4%-12.3% w/w), and speciogynine (0.1%-5.3% w/w) were the major alkaloids in the analyzed kratom products/extracts. Minor kratom alkaloids (corynantheidine, corynoxine, corynoxine B, 7-hydroxymitragynine, isocorynantheidine) were also quantified (0.01%-2.8% w/w) in the analyzed products; however mitraphylline was below the lower limit of quantification in all analyses.
A novel X-linked trichothiodystrophy associated with a nonsense mutation in RNF113A (2015)

The association of RNF113A mutation with non-photosensitive TTD identifies a new locus for these disorders on the X chromosome. The extended phenotype within this family includes panhypopituitarism, cutis marmorata and congenital short oesophagus.
ChemInform Abstract: ORGANOKUPFER‐CHEMIE, RK. VON BENZAL‐ UND AEHNLICHEN CHLORIDEN MIT LITHIUMDIMETHYLKUPFER (1972)

Abstract Lithium‐dimethyl‐kupfer (II) ersetzt die Chloratome in Benzyl‐ und Benzal= Chloriden durch die Methylgruppe.
High-Pressure Structural Phase Transitions in FeAs Based Compounds at Ambient and Low Temperatures (2011)

We report high pressure powder x‐ray diffractions studies for AFe2As2 (A = Ba and Ca) at high pressures up to 56 GPa at 300 K and low temperatures down to 33 K. A phase transition to a collapsed tetragonal phase is observed in AFe2As2. However, at 300 (33) K in Ba‐compound the transition occurs at 26 (29) GPa, which is much higher pressure than 1.7 (0.3) GPa at 300 (40) K in the Ca‐compound, due to its larger volume. The transition to collapsed phase occurs in the two compounds at nearly the same values of unit cell volume and ct/at ratio. We present a detailed analysis of the pressure dependence structure phase transitions and equation of state in these important FeAs compounds.
Two-photon optical data storage (1998)

The generation and application of information is rapidly evolving from text and graphics based to multimedia based, and it will shortly continue to evolve to virtual reality. The evolution between these stages introduces dramatic increases in the amount of data associated with the applications. For example, where text-based meeting notes have given way to emailed copies of vugraphs, future meeting documentation may require storing and communicating an entire collaborative virtual reality session. Even in the near term, the need to store, search for, and edit large numbers of images and digital video clips will drive data storage requirements forward in home, office, and network arenas, as shown in Fre 1 .
Characterization of tissue scaffolds using optics and ultrasound (2011)

Tissue scaffolds are an integral part of the tissue engineering process, assisting in the culturing of cells in three dimensions. It is important to understand both the properties of the scaffold and the growth of cells within the scaffold. This paper describes a system to characterise scaffolds using acoustic techniques alone and the development of an ultrasound modulated optical tomography system to study the growth of cells within the scaffolds. Our interest is in characterising the properties of gel-based and polymer foam-based scaffolds. Results from a purely acoustic system have been used to investigate the properties of foam scaffolds manufactured from synthetic polyesters poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) via a supercritical fluid process. As these are porous materials, they are particularly challenging acoustically as the pores scatter sound significantly. However, it is demonstrated that acoustic signals are detectable through a 6mm thick scaffold. Although acoustics alone can be used to characterize many properties of the scaffolds, useful information can also be obtained from optical techniques e.g. monitoring the growth of cells within the scaffold via optical absorption or fluorescence techniques. Light scattering is of course a significant problem for relatively thick engineered tissue (~5mm). The acoustic approach has been extended to include laser illumination and detection of the ultrasound modulated optical pulse. Images of optically-absorbing materials embedded in gel-based tissue phantoms will be presented demonstrating that a lateral resolution of 250&mu;m and an axial resolution of ~90&mu;m can be achieved in scattering samples.
Test Feasibility of Next-Generation Sequencing Assays in Clinical Mutation Detection of Small Biopsy and Fine Needle Aspiration Specimens (2016)

NGS assays demonstrated clinical utility in solid tumor specimens, including those taken by biopsy or FNA. Preanalytic factors identified by this study that may contribute to NGS assay failure highlight the need for pathologists to revisit tissue processing protocols in order to better optimize cancer mutational profiling.
Methylphenidate in the treatment of female adolescents with cooccurrence of attention deficit/hyperactivity disorder and borderline personality disorder: a preliminary open-label trial (2008)

Recent studies reported symptomatic overlap between attention deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD). Methylphenidate (MPH) is the most efficient treatment for ADHD. We assessed the efficacy and tolerability of MPH treatment in adolescent females who met the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for both disorders. Fourteen BPD/ADHD female adolescents aged 14-19 years were treated with MPH for 12 weeks, targeting ADHD, BPD symptoms, and aggressive behavior, as rated by ADHD-rating scale (ADHD-RS) and Clinical Global Impression-Severity (CGI-S) scale for BPD and aggressive behavior severity. A significant improvement was detected in both ADHD and BPD severity (baseline vs. end point, ADHD-RS: 33.1+/-4.8 vs. 17.6+/-5.2, P<0.001; BPD CGI-S: 4.6+/-0.8 vs. 3.4+/-0.8, P<0.0005, respectively) as well as in aggressive behavior (Aggression CGI-S: 3.5+/-1.3 vs. 1.8+/-0.5, P<0.001). MPH was well tolerated. MPH may be useful and well tolerated in treating some shared symptoms of ADHD and BPD among female adolescents. Controlled studies are needed to substantiate these findings.
CCALK: (When) CVA6 Cache Associativity Leaks the Key (2022)

In this work, we study an end-to-end implementation of a Prime + Probe covert channel on the CVA6 RISC-V processor implemented on a FPGA target and running a Linux OS. We develop the building blocks of the covert channel and provide a detailed view of its behavior and effectiveness. We propose a realistic scenario for extracting information of an AES-128 encryption algorithm implementation. Throughout this work, we discuss the challenges brought by the presence of a running OS while carrying out a micro architectural covert channel. This includes the effects of having other running processes, unwanted cache evictions and the OS’ timing behavior. We also propose an analysis of the relationship between the data cache’s characteristics and the developed covert channel’s capacity to extract information. According to the results of our experimentations, we present guidelines on how to build and configure a micro architectural covert channel resilient cache in a mono-core mono-thread scenario.
Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques (2022)

The work related to animal studies was funded by CDC intramural funds and an interagency agreement between CDC and USAID (USAID/CDC IAA AID-GH-T-15-00002). The work related to the insert formulation was funded by U.S. PEPFAR through USAID under a Cooperative Agreement (AID-OAA-A-14-00010) with CONRAD/Eastern Virginia Medical School. The findings and conclusions of this manuscript are those of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention (CDC), USAID, President's Emergency Plan for AIDS Relief (PEPFAR), Eastern Virginia Medical School (EVMS), or the US government.
An initial systematic study of the linear energy transfer distributions of a proton beam under a transverse magnetic field (2022)

Our results indicate that not only the dose but also LET<sub>d</sub> distortions should be considered to accurately evaluate the biological effectiveness of MR-guided proton beam therapy.
Resistive Switching in Aqueous Nanopores by Shock Electrodeposition (2016)

Solid-state programmable metallization cells have attracted considerable attention as memristive elements for Redox-based Resistive Random Access Memory (ReRAM) for low-power and low-voltage applications. In principle, liquid-state metallization cells could offer the same advantages for aqueous systems, such as biomedical lab-on-a-chip devices, but robust resistive switching has not yet been achieved in liquid electrolytes, where electrodeposition is notoriously unstable to the formation of fractal dendrites. Here, the recently discovered physics of shock electrodeposition are harnessed to stabilize aqueous copper growth in polycarbonate nanopores, whose surfaces are modified with charged polymers. Stable bipolar resistive switching is demonstrated for 500 cycles with &lt;10s retention times, prior to any optimization of the geometry or materials.
A Prototype Implementation of a TTP/C Controller (1997)

&lt;div class="htmlview paragraph"&gt;The SAE has classified automotive electronics into two major categories, body electronics and system electronics. The latter (SAE class C) comprises safety critical functions that are of vital importance for the movement of the vehicle. This paper presents a prototype implementation of TTP, a time-triggered communication system developed for this type of applications. The main purpose of the prototype is to provide a means for verifying the concepts of TTP.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The paper focuses on a description of the hardware developed for the communication system as well as the protocol software. The TTP controller hardware is a custom made industry pack module which allows the use of TTP in conjunction with a wide variety of existing motherboards and host environments. The protocol software consists of a TTP/C protocol state machine and auxiliary modules to access the various hardware units.&lt;/div&gt;
Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (RADAR (UK-MRA Myeloma XV Trial): study protocol for a phase II/III randomised controlled trial (2022)

ISCRTN46841867.
Supplementary Table Legends 1-3 from An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer (2023)

Supplementary Table Legends 1-3 from An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
A wireless composite optical bend loss sensor for pressure and shear measurement (2006)

A composite optical bend loss sensor for the measurement of pressure and shear has been developed. The sensor is composed of two layers of fiberoptic mesh sensors that are molded into a thin polydimethylsiloxane (PDMS) substrate. A 3-D displacement map is generated based on bent-induced intensity attenuations in the fibers when the sensor is pressed. The new design overcame some of the coupling and instability problems in our previously reported microfabricated optical bend loss sensor. Here we will report our preliminary study on the sensor including results from the normal and shear load measurement. The paper will also discuss a RF based wireless data acquisition system that we have developed and demonstrate its operation with the composite sensor.
Synthesis and in Vitro Cytotoxicity Evaluation of Phenanthrene Linked 2,4- Thiazolidinediones as Potential Anticancer Agents (2020)

The current study provides an insight into developing a series of phenanthrene thiazolidinedione derivatives as potential DNA interactive agents which might aid in colon cancer therapy.
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation of Azine and Azole N‐Oxides: Reaction Development, Scope and Applications in Synthesis. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Treatment for T1a Renal Cancer Substratified by Size: “Less is More” (2016)

Radical nephrectomy should be avoided for all tumors 3 cm or less. For renal cancers 2 cm or less partial nephrectomy and thermal ablation are equally effective. For tumors 2.1 to 3 cm partial nephrectomy is better than thermal ablation. We identified significant racial treatment disparities that negatively impact survival in black and Hispanic patients.
Isolation, Structure Determination, and Anti-Cancer Activity of Apoptolidin D (2007)

The isolation, characterization, and preliminary biological activity of apoptolidin D, a new apoptolidin that exhibits anti-proliferative activity against H292 human lung carcinoma cells at nanomolar concentrations, are reported. Its equilibration with isoapoptolidin D and characterization of the latter are also described. [structure: see text].
Lentiviral vector based lineage tracing of hippocampal neural progenitor cells in the adult mouse brain (2013)

status: Published
Multiplexed microfluidic approach for nucleic acid enrichment (2023)

A system for enhancing a nucleic acid sample may include a one pump, a denaturing chamber; a microfluidic hydroxyapatite chromatography device configured for performing hydroxyapatite chromatography on the nucleic acid sample, a sample collector, and tubing connecting the pump with the denaturing chamber, the hydroxyapatite chromatography device and the sample collector such that the pump may be used to move the nucleic acid sample from the denaturing chamber to the hydroxyapatite chromatography device and then to the sample collector.