gebhart/patrepeval huggingface dataset:
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma (2022)

Only a small percentage (<1%) of patients with late-stage lung squamous cell carcinoma (LUSC) are eligible for targeted therapy. Because PI3K/AKT/mTOR signaling, particularly Phosphatidylinositol 3-kinase CA (PIK3CA), is dysregulated in two-thirds of LUSC, and DNA damage response pathways are enriched in LUSC, we tested whether CC-115, a dual mTORC1/2 and DNA-PK inhibitor, sensitizes LUSC to chemotherapy. We demonstrate that CC-115 synergizes with carboplatin in six of 14 NSCLC cell lines, primarily PIK3CA-mutant LUSC. Synergy was more common in cell lines that had decreased basal levels of activated AKT and DNA-PK, evidenced by reduced P-S473-AKT, P-Th308-AKT, and P-S2056-DNA-PKcs. CC-115 sensitized LUSC to carboplatin by inhibiting chemotherapy-induced AKT activation and maintaining apoptosis, particularly in PIK3CA-mutant cells lacking wild-type (WT) TP53. In addition, pathway analysis revealed that enrichments in the IFNα and IFNγ pathways were significantly associated with synergy. In multiple LUSC patient-derived xenograft and cell line tumor models, CC-115 plus platinum-based doublet chemotherapy significantly inhibited tumor growth and increased overall survival as compared with either treatment alone at clinically relevant dosing schedules. IHC and immunoblot analysis of CC-115-treated tumors demonstrated decreased P-Th308-AKT, P-S473-AKT, P-S235/236-S6, and P-S2056-DNA-PKcs, showing direct pharmacodynamic evidence of inhibited PI3K/AKT/mTOR signaling cascades. Because PI3K pathway and DNA-PK inhibitors have shown toxicity in clinical trials, we assessed toxicity by examining weight and numerous organs in PRKDC-WT mice, which demonstrated that the combination treatment does not exacerbate the clinically accepted side effects of standard-of-care chemotherapy. This preclinical study provides strong support for the further investigation of CC-115 plus chemotherapy in LUSC.
Economic Formalism for Optimizing the Design and Energy Management of a Hybrid Wind/Photovoltaic System. (2017)

The objective herein is to establish a set of rules and tools for optimizing both energy management and design of a hybrid wind/photovoltaic production system, coupled to the grid and equipped with an electrochemical storage device. Optimization steps are carried out on the database containing consumption patterns and production resources. The chief optimization criterion is economic, with a focus on minimizing total cost of the system as well as of its installation and use over the long term (15 years). In this article, we will present the existing economic relationships inherent in such a system, prior to developing economic models for each of the various component units.
Figure S9 from Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody (2023)

&lt;p&gt;Supplementary Figure 9 shows the SPR analysis of sasanlimab binding to PD-1 from various species&lt;/p&gt;
Model-based matching and hinting of fonts (1991)

In today's digital computers, phototypesetters and printers, typographic fonts are mainly given by their outline descriptions. Outline descriptions alone do not provide any information about character parts like stems serifs, shoulders, and bowls. But, in order to produce the best looking characters at a given size on a specific printer, non-linear operations must be applied to parts of the character shape. At low-resolution, grid-fitting of character outlines is required for generating nice and regular raster characters. For this reason, grid-fitting rules called hints are added to the character description. Grid-fitting rules require as parameters certain characteristic points within the shape outlines. In order to be able to detect these characteristic points in any given input font, a topological model representing the essence of the shapes found in typographic latin typefaces is proposed. This model includes sufficient information for matching existing non-fancy outline fonts to the model description. For automatic hint generation, a table of applicable hints is added into the topological model description. After matching a given input shape to the model, hints which can be applied to the shape of the given font are taken and added to its outline description. Furthermore, a structural description of individual letter shape parts using characteristic model points can be added to the model. Such a description provides knowledge about typographic structure elements like stems, serifs and bowls.
Improving Electricity and Natural Gas Systems Coordination Using Swing Option Contracts (2019)

The trading of electricity and natural gas, according to the current organizational framework, takes place in independent and sequentially cleared trading floors. This setup leads to imperfect coordination between the two energy systems and it also separates the day-ahead scheduling from the real-time balancing decisions. Acknowledging these market inefficiencies, we propose defining standardized contracts in the form of swing options that allow for a flexible demand pattern according to a predetermined price. In this paper, swing option contracts are parameterized and priced on the gas system side and can be concluded by the power generators to hedge against gas price uncertainty. We perform the contract pricing using a stochastic bilevel optimization model that anticipates the reaction of both systems with respect to contract definition. Our analysis shows that if these contracts are properly priced and valuated by the gas and electricity system, respectively, they can improve intersystem, as well as inter-temporal, coordination and thus reduce the expected system cost.
Design of Compact Arbitrary-Ratio Multimode Power Splitters Based on Topological Derivative (2020)

Compact unbalanced splitters are a key constitutive block to achieve flexibility in future multimode applications relying on silicon-on-insulator technology. Their design, however, poses significant challenges as it has to combine high performance for the different supported modes, a compact size, and compliance with fabrication constraints. In this letter, we employ topological derivative to optimize the design of bimodal unbalanced splitters with predefined split ratios of 2:1 and 3:1. Numerical simulations reveal that the optimized devices achieve the desired ratios with insertion losses of 0.6 dB and 0.5 dB, and crosstalks of -18.2 dB and -16.4 dB, both in a compact footprint of 4.2 μm × 3.5 μm.
Preferential hetero-dimer formation and equilibrium dynamics of self-complementary bifunctional oligo(p-phenylenevinylene) and C60ureido-pyrimidinone derivatives in solution (2002)

The formation of hetero-dimers of bifunctional oligo(p-phenylenevinylene) and C60 ureido-pyrimidinone derivatives has been observed by 1H-NMR and fluorescence techniques.
Biosynthetic intermediates to the macrocyclic trichothecenes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthetic intermediates to the macrocyclic trichothecenesBruce B. Jarvis, Gowsala Pavanasasivam, C. E. Holmlund, Tuley DeSilva, G. Patrick Stahly, and Eugene P. MazzolaCite this: J. Am. Chem. Soc. 1981, 103, 2, 472–474Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ja00392a044https://doi.org/10.1021/ja00392a044research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T2 relaxation times of knee cartilage in 109 patients with knee pain and its association with disease characteristics (2021)

Background and purpose - Quantitative T2 mapping MRI of cartilage has proven value for the assessment of early osteoarthritis changes in research. We evaluated knee cartilage T2 relaxation times in a clinical population with knee complaints and its association with patients and disease characteristics and clinical symptoms.Patients and methods - In this cross-sectional study, T2 mapping knee scans of 109 patients with knee pain who were referred for an MRI by an orthopedic surgeon were collected. T2 relaxation times were calculated in 6 femoral and tibial regions of interest of full-thickness tibiofemoral cartilage. Its associations with age, sex, BMI, duration of complaints, disease onset (acute/chronic), and clinical symptoms were assessed with multivariate regression analysis. Subgroups were created of patients with abnormalities expected to cause predominantly medial or lateral tibiofemoral cartilage changes.Results - T2 relaxation times increased statistically significantly with higher age and BMI. In patients with expected medial cartilage damage, the medial femoral T2 values were significantly higher than the lateral; in patients with expected lateral cartilage damage the lateral tibial T2 values were significantly higher. A traumatic onset of knee complaints was associated with an acute elevation. No significant association was found with clinical symptoms.Interpretation - Our study demonstrates age, BMI, and type of injury-dependent T2 relaxation times and emphasizes the importance of acknowledging these variations when performing T2 mapping in a clinical population.
Dislocation transmission through ∑ = 9 symmetrical tilt boundaries in silicon and germanium (1987)

Abstract In situ experiments using synchrotron X-ray topography and high-voltage electron microscopy (HVEM) have been carried out in order to study dislocation transmission through (122), ∑=9 coincidence tilt boundaries in elemental semiconductors. Both techniques proved that this boundary greatly hinders dislocation motion. However, dislocations with the common ½[011] Burgers vector, parallel to the tilt axis, can be transmitted from one crystal to the other. X-ray experiments brought several other types of transmission to light, but these were not confirmed by HVEM observations. This suggests that they were not true transmission reactions but resulted from the activation of pre-existing nearby dislocation sources by internal stresses arising from dislocation pile-ups against the grain boundary, in the opposite crystal.
ChemInform Abstract: C3 Symmetric Oxazolinyl Ligand as Catalyst in the Enantioselective Addition of Diethylzinc to Aldehydes. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microresonator-Based Frequency Comb Generator as Optical Source for Coherent WDM Transmission (2013)

A high-Q SiN microresonator is used for the first time as an optical source for WDM transmission with advanced modulation formats. We transmit QPSK and 16QAM signals with a total bit rate of 392 Gbit/s.
Theoretical consideration on quantum lithography with conventional projection (2003)

At the end of last century, the name of “quantum lithography” has been emerged. This exciting approach was proposed for making a resolution two times higher than that of the conventional optics without changing a wavelength and a numerical aperture. For those who want optical lithography to last long, this has been thought to be a great technology. However, an applicability of the proposed method to the current exposure system <i>i.e</i>., reduced projection exposure system has not yet been examined clearly. We have investigated the proposed quantum lithography to apply into the current exposure system using reticle. For simplicity, coherent illumination <i>i.e. </i>sigma is zero condition is used for calculation. Our quantum lithography compatible to mask exposure system explains probability of one and two photon absorption on the image plane i.e. on wafer. We have shown that the half-wavelength quantum lithography using conventional mask exposure system is impossible because diffraction at the mask makes biphoton into two photon. We have found that there is still super-resolution quantum lithography using mask exposure, however, there is little possibility of quantum lithography practically today because biphoton light source is as dark as stars. To realize quantum lithography practically, further development of not only biphoton light source but also two-photon absorption resist is indispensable.
Demographic and psychological predictors of community pharmacists’ cancer-related conversations with patients: a cross-sectional analysis and survey study (2022)

Most CPs encourage patients to spot or respond to potential cancer symptoms, while only half help them make an informed decision to participate in bowel cancer screening. A multifaceted approach, targeting multiple COM-B components, is required to change these behaviours.
ChemInform Abstract: Synthesis of Deoxymannojirimycin, Fagomine, Deoxynojirimycin, 2‐Acetamido‐1,5‐imino‐1,2,5‐trideoxy‐D‐mannitol, 2‐Acetamido‐1,5‐imino‐1,2,5‐trideoxy‐D‐glucitol, 2S,3R,4R,5R‐Trihydroxypipecolic Acid and 2S,3R,4R,5S‐Trihydroxypipecolic Acid from Methyl 3‐O‐Benzyl‐2,6‐dideoxy‐2,6‐imino‐α‐D‐mannofuranoside. (1987)

ChemInformVolume 18, Issue 33 Natural Products ChemInform Abstract: Synthesis of Deoxymannojirimycin, Fagomine, Deoxynojirimycin, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, 2S,3R,4R,5R-Trihydroxypipecolic Acid and 2S,3R,4R,5S-Trihydroxypipecolic Acid from Methyl 3-O-Benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside. G. W. J. FLEET, G. W. J. FLEET Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this authorL. E. FELLOWS, L. E. FELLOWS Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this authorP. W. SMITH, P. W. SMITH Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this author G. W. J. FLEET, G. W. J. FLEET Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this authorL. E. FELLOWS, L. E. FELLOWS Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this authorP. W. SMITH, P. W. SMITH Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UKSearch for more papers by this author First published: August 18, 1987 https://doi.org/10.1002/chin.198733320Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue33August 18, 1987 RelatedInformation
Long-range interactions between transcription factors (2005)

We discuss a method for analysing the number of GFP-LacI fusion transcription factors bound to a construct of 256 contiguous LacI binding sites using photon bleaching statics. We show by using a combination of imaging of the construct in nanochannels, photon statistics and addition of IGFP that the binding coefficient of the LacI decreases with increasing occupation of the construct, with a binding coefficient of 10(-6) M when only 15 of the 256 possible sites are occupied. We model this effect by assuming that the GFP-LacI dimer introduces elastic strain into the helix by generalized deformations, and that this strain propagates over distances at least as large as the persistence length.
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses (2021)

SUMMARY The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and development of novel computational methods ( synapse.org/LINCS_MCF10A ). In illustrative analyses, we demonstrate how this dataset can be used to discover functionally related molecular features linked to specific cellular phenotypes.
Developmental Changes in Organization of Structural Brain Networks (2012)

Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be the result of a fine-tuning of the structural and functional organization of brain with maturation. However, the details regarding the developmental trajectory of large-scale structural brain networks are not yet understood. Here, we used graph theory to examine developmental changes in the organization of structural brain networks in 203 normally growing children and adolescents. Structural brain networks were constructed using interregional correlations in cortical thickness for 4 age groups (early childhood: 4.8-8.4 year; late childhood: 8.5-11.3 year; early adolescence: 11.4-14.7 year; late adolescence: 14.8-18.3 year). Late childhood showed prominent changes in topological properties, specifically a significant reduction in local efficiency, modularity, and increased global efficiency, suggesting a shift of topological organization toward a more random configuration. An increase in number and span of distribution of connector hubs was found in this age group. Finally, inter-regional connectivity analysis and graph-theoretic measures indicated early maturation of primary sensorimotor regions and protracted development of higher order association and paralimbic regions. Our finding reveals a time window of plasticity occurring during late childhood which may accommodate crucial changes during puberty and the new developmental tasks that an adolescent faces.
Mechanisms for cooperative shared memory (1993)

This paper explores the complexity of implementing directory protocols by examining their mechanisms primitive operations on directories, caches, and network interfaces. We compare the following protocols: Dir1B, Dir4B, Dir4NB, DirnNB[2], Dir1SW[9] and an improved version of Dir1SW (Dir1SW+). The comparison shows that the mechanisms and mechanism sequencing of Dir1SW and Dir1SW+ are simpler than those for other protocols.
MP98-18 INHIBITION OF HSP90 SYNERGISTICALLY POTENTIATES ANTITUMOR EFFECT OF NVP-BEZ235 AND SATRAPLATIN COMBINATION THERAPY IN CISPLATIN-RESISTANT HUMAN BLADDER CANCER CELLS THROUGH THE DOWN-REGULATION OF AKT AND ERK SIGNALING (2017)

and Nrf2-targeted antioxidative response through inhibiting TRIM-21mediated ubiquitination
Homologous Regulation of Hormone Receptors: Luteinizing Hormone Increases Its Own Receptors in Cultured Rat Granulosa Cells* (1984)

LH receptors in granulosa cells are essential for ovulation and luteinization of ovarian follicles. We have studied the possible role of LH to regulate its own receptors in vitro. Granulosa cells obtained from immature hypophysectomized estrogen-treated rats were primed with FSH for 2 days to induce LH receptors. The cells were then challenged with or without increasing doses of LH or hCG for an additional 2 days, and the concentration of LH receptors was measured by [125I]iodo-hCG binding. FSH-induced LH receptors in granulosa cells decreased to negligible levels in cultures without gonadotropins, while LH receptor numbers were further increased by LH or hCG in a biphasic manner. Maximal stimulation of LH receptor content was obtained with gonadotropin doses of 6, 10, and 2.5 ng/ml for rat LH, ovine LH, and hCG, respectively. In contrast, higher doses of the gonadotropins were less effective. LH stimulation of [125I]iodo-hCG-binding sites was associated with increases in the number of LH receptors, without changes in the Kd value (control, 1.22 +/- 0.22 X 10(-10) M; LH-treated, 2.55 +/- 0.55 X 10(-10) M). Also, the changes in LH receptor numbers were correlated with the responsiveness of granulosa cells to LH stimulation of cAMP production. LH and hCG did not affect overall granulosa cell protein content. However, treatment with cycloheximide, a protein synthesis inhibitor, decreased LH-induced receptors by 46%, suggesting the involvement of new protein synthesis. Thus, these studies have demonstrated that LH, like FSH, is capable of stimulating granulosa cell differentiation by inducing its own receptors. This serves as an interesting model for studies on the positive autoregulation of hormone receptors and explains the important role of LH during advanced stages of follicular maturation.
Every Smile is Unique: Landmark-Guided Diverse Smile Generation (2018)

Each smile is unique: one person surely smiles in different ways (e.g. closing/opening the eyes or mouth). Given one input image of a neutral face, can we generate multiple smile videos with distinctive characteristics? To tackle this one-to-many video generation problem, we propose a novel deep learning architecture named Conditional Multi-Mode Network (CMM-Net). To better encode the dynamics of facial expressions, CMM-Net explicitly exploits facial landmarks for generating smile sequences. Specifically, a variational auto-encoder is used to learn a facial landmark embedding. This single embedding is then exploited by a conditional recurrent network which generates a landmark embedding sequence conditioned on a specific expression (e.g. spontaneous smile). Next, the generated landmark embeddings are fed into a multi-mode recurrent landmark generator, producing a set of landmark sequences still associated to the given smile class but clearly distinct from each other. Finally, these landmark sequences are translated into face videos. Our experimental results demonstrate the effectiveness of our CMM-Net in generating realistic videos of multiple smile expressions.