gebhart/patrepeval huggingface dataset:
Cleavage of methoxymethyl ethers with boron trichloride. A convenient, versatile preparation of chloromethyl ether derivatives (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCleavage of methoxymethyl ethers with boron trichloride. A convenient, versatile preparation of chloromethyl ether derivativesDane A. Goff, Ralph N. Harris III, Jeffrey C. Bottaro, and Clifford D. BedfordCite this: J. Org. Chem. 1986, 51, 24, 4711–4714Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/jo00374a040https://doi.org/10.1021/jo00374a040research-articleACS PublicationsRequest reuse permissionsArticle Views2802Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flexible Demonstrator Platform for Cooperative Joint Transmission and Detection in Next Generation Wireless MIMO-OFDM Networks (2008)

This paper presents a flexible demonstrator platform for cooperative joint transmission and detection in next generation wireless networks, especially cellular networks like 3GPP LTE+. The platform is shown capable of handling computational load as well as network load of jointly processing three ma
An analytical model based on G/M/1 with self-similar input to provide end-to-end QoS in 3G networks (2006)

The dramatic increase in demand for wireless Internet access has lead to the introduction of new wireless architectures and systems including 3G, Wi-Fi and WiMAX. 3G systems such as UMTS and CDMA2000 are leaning towards an all-IP architecture for transporting IP multimedia services, mainly due to its scalability and promising capability of inter-working heterogeneous wireless access networks. During the last ten years, substantial work has been done to understand the nature of wired IP traffic and it has been proven that IP traffic exhibits self-similar properties and burstiness over a large range of time scales. Recently, because of the large deployment of new wireless architectures, researchers have focused their attention towards understanding the nature of traffic carried by different wireless architecture and early studies have shown that wireless data traffic also exhibits strong long-range dependency. Thus, the classical tele-traffic theory based on a simple Markovian process cannot be used to evaluate the performance of wireless networks. Unfortunately, the area of understanding and modeling of different kinds of wireless traffic is still immature which constitutes a problem since it is crucial to guarantee tight bound QoS parameters to heterogeneous end users of the mobile Internet. In this paper, we make several contributions to the accurate modeling of wireless IP traffic by presenting a novel analytical model that takes into account four different classes of self-similar traffic. The model consists of four queues and is based on a G/M/1 queueing system. We analyze it on the basis of priority with no preemption and find exact packet delays. To date, no closed form expressions have been presented for G/M/1 with priority.
Infection and Cancer: The Case of Hepatitis B (2015)

Infection is a well-described cause of cancer in humans. Being one of the most common infections worldwide, hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC), particularly in Asian countries. The etiological link between HBV and HCC provides an important opportunity for health care policy makers and clinicians to intervene with HBV infection to prevent cancer development and improve the outcomes of cancer. This review aims to use HBV as an example to illustrate the potential of tackling infection-related conditions to help improve cancer outcomes. This article is divided into four parts: In the first part, an overview is given on the epidemiologic data and risk factors of HCC development in patients with chronic hepatitis B. In the second part, recent progress on the anti-HBV strategies for preventing HCC is updated. In the third part, approaches to improve the outcomes of established HBV-related HCC are covered. These methods include surveillance strategies to identify asymptomatic HCC among patients with chronic HBV infection, and use of antiviral treatment to avoid HBV reactivation during treatment for HCC and reduce the recurrence of HCC after curative treatment. Finally, the status of the development of targeted drugs specifically for HBV-related HCC is discussed in the section on future development.
Correction to Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria (2020)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant BacteriaJacqueline M. Zaengle-BaroneJacqueline M. Zaengle-BaroneMore by Jacqueline M. Zaengle-Barone, Abigail C. JacksonAbigail C. JacksonMore by Abigail C. Jacksonhttp://orcid.org/0000-0002-2113-3449, David M. BesseDavid M. BesseMore by David M. Besse, Bradford BeckenBradford BeckenMore by Bradford Becken, Mehreen ArshadMehreen ArshadMore by Mehreen Arshad, Patrick C. SeedPatrick C. SeedMore by Patrick C. Seed, and Katherine J. Franz*Katherine J. FranzMore by Katherine J. Franzhttp://orcid.org/0000-0002-9015-0998Cite this: ACS Infect. Dis. 2020, 6, 4, 759Publication Date (Web):March 10, 2020Publication History Received19 February 2020Published online10 March 2020Published inissue 10 April 2020https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00082https://doi.org/10.1021/acsinfecdis.0c00082correctionACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views797Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (445 KB) Get e-Alertsclose Get e-Alerts
Separation ofo-,m- andp-phthalic acids by high-field asymmetric waveform ion mobility spectrometry (FAIMS) using mixed carrier gases (2000)

Baseline separation of the three isomers of phthalic acid was achieved in a mixed gas system containing a 95 : 5 mixture of N(2) and CO(2), even though the acids could not be distinguished by high-field asymmetric waveform ion mobility spectrometry (FAIMS) when either pure N(2) or pure CO(2) was used as the carrier gas. Pseudomolecular anions of o-, m- and p-phthalic acids were generated by electrospray ionization and detected, following separation by FAIMS, using a quadrupole mass spectrometer. Addition of small amounts of CO(2) to an N(2) carrier gas also caused the compensation voltages to increase by as much as 12 V, accompanied by 2-7-fold improvements in the measured ion current and dramatic reductions in both adduct ion formation and parent ion fragmentation. Copyright 2000 John Wiley & Sons, Ltd.
GP education posts for research (2023)

Background Almost every patient and every healthcare condition are seen within primary care, but research is not yet embedded in general practice in the same way it is in secondary care. There is no well-defined pathway for a career combining research delivery and active clinical general practice. Aim In Wessex, we set out to design a career pathway for the clinically active GP that could sustain research involvement throughout their working lifetime and underpin research activity in primary care. Method A lead for education on research was established, in 2021, to approach relevant organisations for funding, accreditation, and design of educational posts for research delivery in primary care. Results Health Education England is currently looking to fund additional placements prior to completion of GP training. NIHR CRN Wessex also identified funding for posts after completion of training. The authors worked with the Southampton GP Education Unit who applied for and achieved the first national recognition of 15-month research placements to count towards completion of GP vocational training. A GP career pathway was designed starting with these posts and followed by GP Research fellow posts, which provide ongoing sessional research work at any stage of a clinical GP career. Conclusion National recognition for education on research has been achieved and a career pathway for GPs to train in and then work in research has been established. This will help embed research expertise and interest within primary care. This should increase research delivery and hence a cycle of increased research funding for further similar posts.
Metal Vapor Synthesis of Organometal Polymers and Polymer-Supported Metal Clusters (1981)

Abstract Metal vapor chemistry has matured from being merely a curiosity and is now established as a viable synthetic technique. Recently the method has been applied to the formation of organometallic polymers and polymer-supported metal clusters. The purpose of this chapter is to provide a short review of the initial studies in the field. The synthesis of organometallic polymers is described via either formation of the organometallic polymer precursor or the reaction of metal vapor with a preformed polymer and the two techniques are compared with respect to the chemical and physical properties of the products. The generation of polymer-stabilized small metal clusters at ambient temperatures, by the deposition of a metal vapor into fluid polymer, thin films, is then discussed with particular reference to the combination of matrix-scale and macrosynthetic metal vapor synthesis. Some thoughts regarding the mode of stabilization of metal clusters are also presented. Finally, a brief description of the formation, by evaporation techniques, of metal particle-polymer interactions is included to indicate other types of experiment which may be used.
Influence of Excitation Frequency and Amplitude on the Switching Properties of SBT and PZT Thin Films at 10 MHZ Hysteresis Frequency (2002)

For development and optimization of high density ferroelectric random access memory (FeRAM) devices, it is highly important to understand the polarization switching process. As demands on measurement hardware for these nonlinear devices rise with falling cycle time, the development of faster measurement equipment is desired for observation. We report on the direct investigation of the switching behaviour near device operation frequency of chemical solution deposition (CSD) prepared thin films of perovskite materials such as strontium bismuth tantalate SrBi 2 Ta 2 O 9 (SBT) and lead zirconate titanate Pb(Zr 0.3 ,T 0.7 )O 3 (PZT) with a newly developed measurement setup. In this work, high speed dynamic hysteresis measurements are performed to further explore the dynamic behaviour of polarization switching into the frequency domain. Virtual Ground measurements down to 100 ns cycle time of excitation signal were achieved, providing additional insight into device operation. A rise of Vc with a factor of 0.065 kV/decade between measurements at 10 Hz and 10 MHz of excitation frequency was confirmed.
Ultrasmall MOSFETs: the importance of the full Coulomb interaction on device characteristics (2000)

A novel scheme that accounts for the short-range Coulomb forces and prevents the double-counting of the long-range interaction is described in the context of three-dimensional (3-D) ensemble Monte Carlo particle-based simulations. It is shown that the inclusion of full Coulomb interactions strongly affects both the threshold voltage, the carrier dynamics and the resulting device characteristics. The proper treatment of the short-range Coulomb forces significantly reduces the distances over which thermalization of the carriers occurs in the drain region and leads to about a factor of two smaller on-state drain currents. The proposed scheme was successfully used to describe fluctuations in various device parameters due to the random dopant fluctuations. Correlation of device threshold voltage to the number of dopant atoms at a given depth showed that most dopant atoms have an impact on the threshold voltage, while only those in the top 8-10 nm affect the device velocity.
Synthesis of 5-N-Substituted Tetrazole Derivatives of the Potent NK1 Receptor Antagonist GR203040 (1996)

A series of amino-tetrazole derivatives of GR203040 were synthesised as potential NK1 receptor antagonists. The synthesis of these analogues utilised a novel reaction sequence in which 1-aryl tetrazoles were converted to 1-aryl-5-amino-tetrazoles via a cyanoamide intermediate.
Controlled capacitive gaps for electrostatic actuation and tuning of 3D fused quartz micro wineglass resonator gyroscope (2017)

In this paper, we present the assembly process and an electrostatic actuation, detection, and tuning method of micro-glassblown wineglass resonators using an out-of-plane electrode architecture with controlled uniform capacitive gaps. This process is developed based on wafer-level deposition of a sacrificial layer on planar electrodes wafer to achieve a uniform electrostatic gap (<5µm). The materials, bonding type, etch selectivity, temperature and vacuum compatibility of the process are considered in the assembly process of the micro-glassblown fused quartz shell resonators. Tuning the frequency mismatch between two orthogonal (n=2) in-plane wineglass modes is demonstrated experimentally on a 7 mm micro-glassblown wineglass resonator using the out-of-plane electrodes. An open-loop rate response is demonstrated using out-of-plane capacitive actuation and detection. The proposed process enables a low-cost assembly with a high transduction efficiency toward wafer-scale fabrication of micro 3D wineglass gyroscopes.
Figure S1 from Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors (2023)

&lt;p&gt;Telomerase activity in pediatric brain tumor cells MB004, R0315-GBM, SU-DIPG-VI, CCHMC-DIPG-1, D-458, D-425, in normal diploid fibroblast cells HFF and HFF+hTERT, and in osteosarcoma cells Saos2 and U2OS. (-) C, (+) C, and IC indicate negative control, positive control, and internal control respectively. Telomerase products are indicated.&lt;/p&gt;
56 SJO2 MONITORING BY INTERMITTENT SAMPLES DOES NOT INFLUENCE THE MANAGEMENT OF SEVERE HEAD TRAUMA PATIENTS (1999)

Rasulo, F; Latronico, N; Beindorf, A; Stefini, R; Galli, G; Candiani, A Author Information
Trans , trans , trans -[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism (2012)

Photoactivatable Pt(IV) diazido complexes have unusual photobiologic properties. We show here that trans,trans,trans-[Pt(IV)(N(3))(2)(OH)(2)(py)(NH(3))] complex 3 is a potent photoactivated cytotoxin toward human cancer cells in culture, with an average IC(50) value in 13 cell lines of 55 ± 28 μmol/L after 30 minutes (0.12 mW/cm(2)) photoactivation with UVA, although visible light was also effective. Photoactivated complex 3 was noncross-resistant to cisplatin in 3 of 4 resistant cell lines. Cell swelling but very little blebbing was seen for HL60 cells treated with irradiated complex 3. Unlike cisplatin and etoposide, both of which cause apoptosis in HL60 cells, no apoptosis was observed for UVA-activated complex 3 by the Annexin V/propidium iodide flow cytotometry assay. Changes in the levels of the autophagic proteins LC3B-II and p62 in HL60 cells treated with UVA-activated complex 3 indicate autophagy is active during cell death. In a clonogenic assay with the SISO human cervix cancer cell line, 3 inhibited colony formation when activated by UVA irradiation. Antitumor activity of complex 3 in mice bearing xenografted OE19 esophageal carcinoma tumors was photoaugmented by visible light. Insights into the novel reaction pathways of complex 3 have been obtained from (14)N{(1)H} nuclear magnetic resonance studies, which show that photoactivation pathways can involve release of free azide in buffered solution. Density functional theory (DFT) and time-dependent DFT calculations revealed the dissociative character of singlet and triplet excited states of complex 3, which gives rise to reactive, possibly cytotoxic azidyl radicals.
Low Power Synthesis of Dynamic Logic Circuits Using Fine-Grained Clock Gating (2006)

Clock power consumes a significant fraction of total power dissipation in high speed precharge/evaluate logic styles. In this paper, we present a novel low-cost design methodology for reducing clock power in the active mode for dynamic circuits with fine-grained clock gating. The proposed technique also improves switching power by preventing redundant computations. A logic synthesis approach for domino/skewed logic styles based on Shannon expansion is proposed, that dynamically identifies idle parts of logic and applies clock gating to them to reduce power in the active mode of operation. Results on a set of MCNC benchmark circuits in predictive 70nm process exhibit improvements of 15% to 64% in total power with minimal overhead in terms of delay and area compared to conventionally synthesized domino/skewed logic
RF01 | PMON167 Isolated Cushing's Disease Associated With Rare Germline SDHx Variants (2022)

Abstract Introduction Loss-of-function (LOF) germline variants in the SDHx genes (SDHA, SDHB, SDHC, and SDHD), encoding the succinate dehydrogenase subunits, are a rare cause for pituitary tumors in the setting of various familial tumor syndromes. Occasional case reports have highlighted SDHx mutations in isolated pituitary tumors (including one case of Cushing's disease, CD). The actual frequency of SDHx variants as genetic drivers of pituitary tumors, however, remains elusive. Aim We sought to determine the frequency of germline SDHx variants in a large cohort of CD patients. Methods Of the 245 unrelated CD patients studied (139 females, 56.7%; 230 pediatric, 93.9%), 184 underwent whole-exome sequencing (WES) of peripheral blood and 27 of them underwent additional tumor WES. Forty-three additional germline samples and 92 tumor samples underwent Sanger sequencing of specific genes. Rare variants of uncertain significance (VUS), likely pathogenic or pathogenic variants of the SDHx genes were reviewed. Immunocytochemistry was used to analyze protein expression in tumor samples. Results Germline heterozygous variants of SDHA (three missense and one frameshift) and SDHD (two missense) were identified in six patients (four female; mean age of 8.8±2.2 years at onset of CD and 11.5±2.6 years at diagnosis). The variants were inherited in all 5 cases where parental germline samples were available. We found the following SDHA variants: Case 1 carried p.A21T (absent from gnomAD), Case 2 carried p.L74Ffs*9 (absent from gnomAD), Case 3 carried p.I235T (allele frequency, MAF=0.0100% in gnomAD exomes), and Case 4 carried p.H424Q (MAF=0.0056% in gnomAD exomes). Two patients (Cases 5 and 6) carried the SDHD missense VUS c.53C&amp;gt;T, p.A18V (MAF= 0.0068% in gnomAD exomes). Case 6 had a maternal family history of familial isolated pituitary adenomas, but an SDHD variant of paternal origin; disease presentation was apparently sporadic in the rest of cases. Case 2 displayed somatic loss of heterozygosity (LOH) for the SDHA variant, while no LOH was found in the three other cases tested. Somatic hotspot variants were absent in all tumors tested in USP8 (5/5 cases), USP48 (4/4 cases), and BRAF (4/4 cases). All patients carried microadenomas and achieved remission after one transsphenoidal surgery. Case 4 was diagnosed with a Crooke's cell corticotropinoma and also carried germline VUS in DICER1 and TSC2. In all three tumors tested, SDHx subunit expression was reduced: SDHB reduced in Cases 2, 4, and 5; SDHA reduced in Cases 2 and 4; absent SDHD in Case 2, and absent SDHC in case 5. Conclusion Altogether, SDHx variants were found in 2.4% of the cohort (2.6% of pediatric patients). Our findings suggest that germline SDHx variants are a rare but significant genotype associated with isolated sporadic Cushing's disease. * JLM and CAS contributed equally. Presentation: Saturday, June 11, 2022 1:24 p.m. - 1:29 p.m., Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.