gebhart/patrepeval huggingface dataset:
Pamiparib, a novel PARP 1/2 inhibitor, monotherapy for gBRCAm patients with recurrent ovarian, fallopian, and primary peritoneal cancer: An open-label, multicenter, phase II trial in China (2018)

Background: Poly (ADP-ribose) polymerase inhibitors (PARPis) represent a class of antitumor agents that exert their cytotoxic effects by inhibiting PARP activity. PARPis are also capable of trapping PARP proteins complexes on damaged DNA, further augmenting cell death. Pamiparib is a selective PARP1/2 inhibitor with potent PARP trapping ability that can cross the blood-brain barrier and has demonstrated antitumor activity in both in vitro and in vivo nonclinical tumor models harboring BRCA gene mutations (BRCAmut) and other homologous recombination deficiencies. In Phase 1 studies (NCT02361723; NCT03333915), single-agent pamiparib was generally well tolerated and showed antitumor activity, notably in patients with high-grade non-mucinous ovarian cancer (HGOC). Antitumor activity was observed in patients with BRCA mutant and BRCA wild type ovarian cancers, whose tumors were either sensitive or had platinum-resistant disease. Data from these Phase 1 studies support the recommended Phase 2 pamiparib monotherapy dose of 60 mg PO BID. Trial design: In this ongoing study of pamiparib in China (NCT03333915), patients with HGOC harboring germline BRCAmut who have received ≥2 prior lines of therapy are being enrolled in the Phase 2 part of the study. Patients with either platinum-sensitive (progression occurring ≥6 months after last dose of platinum) or platinum-resistant (progression occurring <6 months after last dose of platinum) HGOC are eligible. Germline BRCAmut status is identified or confirmed by central testing before enrollment. Approximately 100 patients with HGOC (platinum-sensitive, n = 80; platinum-resistant, n = 20) will receive pamiparib 60 mg PO BID until disease progression. The primary objective is to assess overall response rate according to RECIST v1.1; secondary objectives include assessment of pamiparib’s safety, tolerability, and pharmacokinetic profile. Evaluation of antitumor activity will include an estimation of overall and progression-free survival, as well as duration of clinical response. Clinical trial identification: NCT03333915. Editorial acknowledgement: Medical writing and editorial support was provided by Regina Switzer, PhD (SuccinctChoice Medical Communications, Chicago, IL). Legal entity responsible for the study: Beigene, Ltd. Funding: Beigene, Ltd. Disclosure: T. Gu, K. Zhang, J. Liang, S. Mu, R. Ge, H. Yang, V. Huang, R. Brachmann, L. Wang, M. Li: Employee: BeiGene. All other authors have declared no conflicts of interest.
Generation of divacancies in silicon irradiated by 2-MeV electrons: Depth and dose dependence (1987)

Czochralski-grown silicon samples (n-type) have been irradiated by 2-MeV electrons at room temperature to doses in the range of 1015–1016 cm−2. The generation of divacancies (V2) has been studied as a function of bombardment dose and sample depth using deep-level transient spectroscopy (DLTS). In the DLTS spectra, a level ∼0.41 eV below the conduction band is attributed to V2 in accordance with previous assignments made by other authors. It is shown that the generation rate of V2 is not only determined by the primary electron energy, but also depends on the bombardment dose. Initially, the divacancy concentration depends linearly on dose while at high doses a gradual decrease in the generation rate occurs. The concentration of V2 increases significantly with depth close to the surface (≤3 μm) while for larger depths a constant value is reached. The experimental depth profiles are qualitatively compared with a theoretical curve. This curve is calculated assuming vacancy diffusion, and it is speculated that a substantial amount of the divacancies are formed by vacancy-vacancy pairing. Furthermore, in some samples the depth profile of a level ∼0.23 eV below the conduction band is also monitored and based on these results the level scheme for V2 is discussed.
Synthesis and reactions of hydrido(.eta.1-allyl)- and hydrido(.eta.3-allyl)iridium complexes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactions of hydrido(.eta.1-allyl)- and hydrido(.eta.3-allyl)iridium complexesWilliam D. McGhee and Robert G. BergmanCite this: J. Am. Chem. Soc. 1985, 107, 11, 3388–3389Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/ja00297a078https://doi.org/10.1021/ja00297a078research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Development and Validation of a Calculation Routine for the Precise Determination of Pulse Overlap and Accumulated Fluence in Pulsed Laser Surface Treatment (2022)

In laser material processing, a variety of parameters like pulse fluence, total dose, step size, and pulse‐to‐pulse overlap are used to define and compare laser processes. Of these parameters, the pulse‐to‐pulse overlap can be the hardest to access as it is not implemented directly but instead depends on the spot diameter, its shape, and the respective scanning path that is used to cover the surface. This article shows that existing calculation routes overestimate the actual overlap by up to 21%. A novel calculation route is developed that greatly facilitates the determination of the pulse overlap and thereby the average number of laser pulses that interact with a given point on the surface. This approach makes it possible to achieve more reliable and comparable laser processes, which in return leads to better control of the procedure as the effect of individual parameters on a given output can be determined with greater precision.
Compact all-fiber optical Faraday components using 65-wt%-terbium–doped fiber with a record Verdet constant of −32 rad/(Tm) (2010)

A compact all-fiber Faraday isolator and a Faraday mirror are demonstrated. At the core of each of these components is an all-fiber Faraday rotator made of a 4-cm-long, 65-wt%-terbium-doped silicate fiber. The effective Verdet constant of the terbium-doped fiber is measured to be -32 rad/(Tm), which is 27 x larger than that of silica fiber. This effective Verdet constant is the largest value measured to date in any fiber and is 83% of the Verdet constant of commercially available crystal used in bulk optics-based isolators. Combining the all-fiber Faraday rotator with fiber polarizers results in a fully fusion spliced all-fiber isolator whose isolation is measured to be 19 dB. Combining the all-fiber Faraday rotator with a fiber Bragg grating results in an all-fiber Faraday mirror that rotates the polarization state of the reflected light by 88 +/- 4 degrees .
Synthesis of P-Substituted 5- and 6-Membered Benzo-Phostams: 2,3-Dihydro-1H-1,2-benzazaphosphole 2-Oxides and 2,3-Tetrahydro-1H-1,2-benzazaphosphinine 2-Oxides (2021)

Several approaches were developed for the preparation of phosphorus-substituted 5- and 6-membered benzophostams. Carbodiimide-promoted cyclization of zwitterionic aminophosphinates derived from a nitrobenzene precursor accomplished the cyclization in good yields. Alternatively, a novel copper-catalyzed cross-coupling between a phosphonamide and a bromobenzene precursor produced the heterocycles in moderate to good yields. Three different methods are compared for the synthesis of the <i>P</i>-ethoxy-substituted 5-membered benzophostam.
Editorial: Mechanisms for the Alteration in the Crosstalk Among Insulin-Sensitive Tissues (2022)

EDITORIAL article Front. Endocrinol., 14 April 2022Sec. Diabetes: Molecular Mechanisms https://doi.org/10.3389/fendo.2022.883659
Friction Stir Welding for Assembly of Copper Squirrel Cage Rotors for Electric Motors (2020)

The automotive industry is developing designs and manufacturing processes for new generations of electric motors intended for use in hybrid and electric vehicles. This paper focuses on solid-state welding to join copper end rings to copper spokes in the fabrication of copper rotors. Friction stir welding was explored to examine weldability of these copper components. Defect free welds were produced on 8-9.5 mm thick copper plates with copper spokes through slots at a travel speed of 225 mm/min and a tool speed rotation of 2250 rpm using lanthanated tungsten as the welding tool. The H13 and nimonic tool materials underperformed due to higher welding temperatures. The conditions were optimized by monitoring the tool and copper plate temperatures. Several tool geometries were investigated and the scrolled shoulder with tri-flat threaded pin performed the best. The strength and weld characteristics were sufficient for this application. Finally, this work puts forth major welding process for induction copper rotors.
Solution NMR and calorimetric analysis of Rem2 binding to the Ca 2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca 2+ currents (2015)

Rem, Rad, Kir/Gem (RGK) proteins, including Rem2, mediate profound inhibition of high-voltage activated Ca(2+) channels containing intracellular regulatory β subunits. All RGK proteins bind to voltage-gated Ca(2+) channel β subunit (Cavβ) subunits in vitro, but the necessity of the interaction for current inhibition remains controversial. This study applies NMR and calorimetric techniques to map the binding site for Rem2 on human Cavβ4a and measure its binding affinity. Our experiments revealed 2 binding surfaces on the β4 guanylate kinase domain contributing to a 156 ± 18 µM Kd interaction: a hydrophobic pocket lined by 4 critical residues (L173, N261, H262, and V303), mutation of any of which completely disrupted binding, and a nearby surface containing 3 residues (D206, L209, and D258) that when individually mutated decreased affinity. Voltage-gated Ca(2+) channel α1A subunit (Cav2.1) Ca(2+) currents were completely inhibited by Rem2 when co-expressed with wild-type Cavβ4a, but were unaffected by Rem2 when coexpressed with a Cavβ4a site 1 (L173A/V303A) or site 2 (D258A) mutant. These results provide direct evidence for a low-affinity Rem2/Cavβ4 interaction and show definitively that the interaction is required for Cav2.1 inhibition.
Digitally enhanced high speed ADC for low power wireless applications (2017)

The digitally-enhanced high speed (200 Msps) analog-to-digital converter (ADC) includes dynamically configurable digital signal post-processing options such as a digital down-converter for In-phase and Quadrature signal detection (I/Q demodulation), digital decimation filter for achieving higher signal-to-noise ratio (SNR), and digital beamforming that allows phase corrections of incoming signals in multi-channel operations. The high speed ADC with the dynamically reconfigurable digital features can simplify today's RF system designs, and allows low power operation. This paper describes how these features can be utilized for portable wireless designs, industrial and automotive wireless sensors applications, etc.
Deformable registration of the inflated and deflated lung in cone‐beam CT‐guided thoracic surgery: Initial investigation of a combined model‐ and image‐driven approach (2012)

The initial studies show the proposed registration method to successfully register CBCT images of the inflated and deflated lung. Accuracy appears sufficient to localize the target and adjacent critical anatomy within ∼1-2 mm and guide localization under conditions in which the target cannot be discerned directly in CBCT (e.g., subtle, nonsolid tumors). The ability to directly localize tumors in the operating room could provide a valuable addition to the VATS arsenal, obviate the cost, logistics, and morbidity of preoperative tagging, and improve patient safety. Future work includes in vivo testing, optimization of workflow, and integration with a CBCT image guidance system.
Evidence that lipid peroxidation by doxorubicin does not initiate the beat inhibition of cultured mouse myocardial cells. (1987)

In order to elucidate the biochemical mechanism by which doxorubicin (DX) induces cumulative dose-dependent cardiomyopathy, the effect of DX on beating and on lipid peroxide level in myocardial cells was investigated by using a mouse myocardial cell culture system. Inhibition by DX of the beating of cultured myocardial cells was dose-and exposure time-dependent. When incubated with DX for 0.5 h, the number of beating cells decreased to 74% at 172 μM, 52% at 345 μM and 37% at 517 μM, and the lipid peroxide level in the cells increased significantly at 345 μM DX or more. At the low dose of 3.5 μM DX, though the number of beating cells decreased to 72% at 24 h, the lipid peroxide level in the cells was about the same as that without DX at 24 h, and increased to about 1.5 times that of the control at 48 h. Under the same conditions as above, 120μM α-tocopherol (Toc) added in advance of the treatment reduced by 86% the lipid peroxidation by DX, but did not protect the beating from DX toxicity. In contrast, 120 μM coenzyme Q10 (CoQ10) reduced the lipid peroxidation by only 33%, but increased the number of beating cells at 48 h from 42% to 68%. We conclude that the lipid peroxidation by DX does not initiate the beat inhibition of cultured myocardial cells, and that the protective effect of CoQ10 on beating is also based on biochemical actions other than reduction of the lipid peroxidation.
The Degradation of Optical Properties in a Sulfuric Acid Anodized Aluminum Coating System Exposed to Vacuum or Vacuum-Ultraviolet Radiation (1997)

Abstract A model for the optical property changes of a sulfuric acid anodized aluminum coating system was formulated to include the effects of water loss and cracking of the coating when the coating is exposed to either vacuum or vacuum-ultraviolet (VUV) radiation. The coating system was modeled as a single layer on an aluminum substrate and a discontinuous layer on an aluminum substrate in the case of cracks being present. Multiple scattering interactions were neglected because of thick film approximations. The effects of the water loss-induced densification and cracking of the coating were modeled independently to produce relationships which can be used to model the reflectance spectra. Densification of the coating with water loss theoretically reduces coating transmittance and total reflectance; cracks tend to reduce the effective reflecting area, resulting in a decrease in total reflectance. The overall models correlate well with experimental reflectance data which show significant changes at the short wavelength region.
Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data (2022)

Parchment was used as a writing material in the Middle Ages and was made using animal skins by liming them with Ca(OH) 2 . During liming, collagen peptides containing Glutamine (Q) undergo deamidation resulting in a mass shift of 0.984 Da. Assessing the extent of deamidation can inform us about parchment production patterns and quality. In this study, we propose a simple three-step workflow, developed as an R package called 'MALDIpqi()', to estimate deamidation in parchment derived collagen using low-resolution MALDI-TOF spectra. After pre-processing raw spectra, we used weighted least-squares linear regression to estimate Q deamidation levels from the convoluted isotopic envelope for seven collagen-peptide markers. Finally, we employed a linear mixed effect model to predict the overall deamidation level of a parchment sample termed the Parchment Glutamine Index (PQI). To test the robustness of the workflow, we applied MALDIpqi() to previously published ZooMS data generated from almost an entire library of the Cistercian monastery at Orval Abbey, Belgium. In addition to reliably predicting PQI, we observed interesting patterns pertaining to parchment production. MALDIpqi() holds excellent potential for biocodicological and other archaeological studies involving collagen, such as bone, but we also foresee its application in the food and biomedical industry.
SPINALLY ELICITED NEUROGENIC "MOTOR" EVOKED POTENTIALS (NMEPs) ASSESS SENSORY RATHER THAN MOTOR FUNCTION (1999)

Toleikis, J. Richard; Skelly, Jon P.; Carlvin, Arnold O.; Burkus, J. Kenneth Author Information
Treatment of experimental lens capsular tears with intense focused ultrasound. (1985)

High-intensity focused ultrasound was employed to seal lens capsular tears in a rabbit model. Ultrasound therapy was applied either contiguously, thereby completely covering the tear, or in a discrete exposure pattern around the tear. Both methods prevented the formation of a generalised cataract. This was in contrast to results observed in a group of control (untreated) animals which all developed generalised lens opacities. Each control animal also developed a local lens opacity at the site of the capsular tear, as did half the animals treated with the discrete pattern. No animal treated with contiguous exposures developed any local or generalised traumatic-type cataract other than the small lens opacity immediately produced by the treatment. These treatment cataracts would not constitute a significant impediment to vision so long as they did not fall on the visual axis.
Temperature-triggered gate opening for gas adsorption in microporous manganese formate (2008)

Microporous manganese formate shows temperature-triggered gate opening for nitrogen and argon adsorption, which is not due to a structural change of the framework but due to dynamic opening of the pore aperture and/or sufficient kinetic energy of the adsorbates to overcome a diffusion barrier above a critical temperature.
Effect of partially immobilizing sorption on permeability and the diffusion time lag (1976)

Abstract The gas permeability and diffusion time lag may exhibit varying degrees of pressure dependence for glassy polymers. The sorption isotherm appears to consist of contributions from both Langmuir and Henry's law terms in such systems. This “dual sorption” theory advanced in the literature pictures gas held by the Langmuir mode as being completely immobilized. In the present paper, this model is extended to accommodate different degrees of partial immobilization of gas sorbed by this mode using two different formulations. One uses a transport expression based on concentration gradients while the other is based on chemical potential gradients. The predictions are that: ( 1 ) total immobilization results in a constant permeability with a time lag which strongly decreases with pressure; ( 2 ) no immobilization results in a constant time lag with a permeability which decreases strongly with pressure; and ( 3 ) incomplete immobilization results in both the permeability and time lag decreasing with pressure but neither as strongly as in the other limiting cases. The differences which may arise by the two formulations of the model are discussed.
A Cross‐Canada Survey of Cytomegalovirus Prevention and Treatment Practices in Bone Marrow Transplant Recipients (1999)

Practices for the prevention of CMV disease in BMT patients differ widely across centres, and further data may assist in developing a consensus regarding the optimal approach to CMV management.
Low-volume PFC rectifier based on non-symmetric multi-level boost converter (2013)

This paper introduces a universal-input digitally-controlled single-phase rectifier with power factor correction (PFC) based on a modified multi level boost converter topology. In comparison with the conventional boost-based systems and other multi-level solutions the new PFC rectifier has significantly smaller inductor and lower switching losses. The improvements are achieved by replacing the output capacitor of the boost converter with a non-symmetric active capacitive divider and by utilizing downstream converter stage for the divider charge balancing. Experimental results obtained from a 400W, 200KHz, universal input voltage (90V-260V) to 400V PFC prototype demonstrate three times smaller inductor current ripple, allowing for the same inductor reduction, and up to 50% reduction in power losses, resulting in 6% efficiency improvement compared to a conventional boost PFC.
Comparative study of electroabsorption in InGaN∕GaN quantum zigzag heterostructures with polarization-induced electric fields (2008)

We present a comparative study on InGaN∕GaN quantum zigzag structures embedded in p-i-n diode architecture that exhibit blue-shifting electroabsorption in the blue when an electric field is externally applied to compensate for the polarization-induced electric field across the wells. With the polarization breaking their symmetry, the same InGaN∕GaN quantum structures redshift their absorption edge when the external field is applied in the same direction as the well polarization. Both computationally and experimentally, we investigate the effects of polarization on electroabsorption by varying compositional content and structural parameters and demonstrate that electroabsorption grows stronger with weaker polarization in these multiple quantum well modulators.
Single fiber confocal microscope with a two-axis gimbaled MEMS scanner for cellular imaging (2006)

We present a single fiber reflectance confocal microscope with a two dimensional MEMS gimbaled scanner. Achieved lateral and axial resolutions are 0.82 mum and 13 mum, respectively. The field of view is 140 x 100 mum at 8 frames/second. Images and videos of cell phantoms and tissue are presented with sub-cellular resolution.
Instabilities in Parallel Channel of Forced-Convection Boiling Upflow System, (IV) (1981)

The steam generator for LMFBR is composed of multiple tubes with the different flow conditions from each other. Most of the computer codes developed to evaluate the stability analyze a representative tube on the basis of the assumption of the constant pressure drop between the feedwater header and the steam one as single channel. Although the method selecting the representative channel has never been investigated, it is one of the purposes of this paper to examine the approximate method to evaluate the stable boundary exactly. It is another purpose of this paper to research the mechanism of the limit cycle oscillation observed in 1 MW SG without the thermal insulated downcomer of Power Reactor and Nuclear Fuel Development Corp., so that the effect of boiling in downcomer on the flow instability is studied experimentally. The slug excursion instability, which does not belong to Bouré's classification of two-phase flow instability, is observed in our experimental apparatus. Then, this mechanism is studied under the various conditions of heat fluxes of downcomer and riser, liquid temperature and inlet velocity