gebhart/patrepeval huggingface dataset:
Manganese(III)-based asymmetric oxidative free-radical cyclization of unsaturated .beta.-keto sulfoxides (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTManganese(III)-based asymmetric oxidative free-radical cyclization of unsaturated .beta.-keto sulfoxidesBarry B. Snider, Barbara Yu Fong Wan, Brad O. Buckman, and Bruce M. FoxmanCite this: J. Org. Chem. 1991, 56, 1, 328–334Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jo00001a061https://doi.org/10.1021/jo00001a061research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Methods and systems for monitoring a solid-liquid interface (2023)

Methods and systems are provided for monitoring a solid-liquid interface, including providing a vessel configured to contain an at least partially melted material; detecting radiation reflected from a surface of a liquid portion of the at least partially melted material; providing sound energy to the surface; measuring a disturbance on the surface; calculating at least one frequency associated with the disturbance; and determining a thickness of the liquid portion based on the at least one frequency, wherein the thickness is calculated based on L=(2m-1)v.sub.s/4f, where f is the frequency where the disturbance has an amplitude maximum, v.sub.s is the speed of sound in the material, and m is a positive integer (1, 2, 3, . . . ).
Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway (2016)

Baicalein, a flavonoid originally obtained from the roots of Scutellaria baicalensis Georgi, has been reported to possess various biological properties. Although several studies have demonstrated the anti-oxidative activity of baicalein, its neuroprotective mechanisms have not been clearly established. The present study aimed to detect the effects of baicalein against hydrogen peroxide (H2O2)-induced neuronal damage in C6 glial cells and to investigate the molecular mechanisms involved in this process. The results demonstrated that baicalein effectively inhibited H2O2-induced growth and reactive oxygen species (ROS) generation. We noted that Baicalein also attenuated the H2O2‑induced formation of comet tail, phosphorylation of p-γH2A.X, loss of mitochondrial membrane potential (MMP or ΔΨm), and changes to apoptosis‑related protein expression, which suggests that it can prevent H2O2‑induced cellular DNA damage and apoptotic cell death. Furthermore, treatment with baicalein effectively induced the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) as well as heme oxygenase-1 (HO-1) and thioredoxin reductase 1 (TrxR1) in a concentration and time-dependent manner. Moreover, the protective effects of baicalein against H2O2‑induced DNA damage and apoptosis were abolished by zinc protoporphyrin (ZnPP) IX, a HO-1 inhibitor, and auranofin, a TrxR inhibitor. In addition, we noted that the cytoprotective effects of baicalein were attenuated by transient transfection with Nrf2-specific small interfering RNA (siRNA). The findings of our present study suggest that baicalein enhances cellular antioxidant defense capacity through the inhibition of ROS generation and the activation of the Nrf2 signaling pathway, thus protecting C6 cells from H2O2-induced neuronal damage.
Roundworm Cells and Cancer Genes (1993)

By studying a creature the size of this comma, biologists may be closing in on the secrets of the human body's cancer-causing genes.
Oral Medroxyprogesterone Acetate and Combination Oral Contraceptives for Acute Uterine Bleeding (2006)

II-1.
Variability in the tertiary structure of α-chymotrypsin at 2.8-Å resolution (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVariability in the tertiary structure of α-chymotrypsin at 2.8-Å resolutionAlexander Tulinsky, Richard L. Vandlen, Carl N. Morimoto, N. Venkit Mani, and Lynn H. WrightCite this: Biochemistry 1973, 12, 21, 4185–4192Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/bi00745a023https://doi.org/10.1021/bi00745a023research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coordination structure and magnetic property of poly(pyridilenemethylidenenitriloiron)s (1989)

Abstract Poly[bis(2,6‐pyridinediylmethylidenenitrilohexamethylenenitrilomethylidene)iron sulfate] was said to be a ferromagnetic compound by earlier investigators. This polymer and its derivatives are carefully reprepared and their unusual magnetic property is reinvestigated spectroscopically. The counter anion species and spacer length of the polymers affect their coordination structure and magnetism. Mössbauer spectroscopy and x‐ray diffractometry on the polymers indicate that their unusual magnetic property is caused by the ferromagnetic iron oxide slightly formed in the polymers.
Is synaesthesia one condition or many? A large‐scale analysis reveals subgroups (2011)

Synaesthesia is a broadly defined neural phenomenon in which stimulation of a sense or concept triggers a second perception not normally associated with the stimulus. For example, letters or numbers may trigger a colour experience, sounds may trigger a taste sensation, or tastes may trigger a feeling of touch. Dozens of forms of synaesthesia have been reported, but the relationship between the different forms has not been studied: is someone with a particular form of synaesthesia likely to possess other types? If so, which ones? As an inroad to illuminating underlying mechanisms, we here examine which different synaesthesia types tend to co-occur. We analyzed reports of the forms of synaesthesia experienced by 19,133 participants who completed the Synaesthesia Battery (Eagleman, Kagan, Nelson, Sagaram, & Sarma, 2007), using correlation analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and multidimensional scaling (MDS). Our analyses converged on the finding of five distinct groupings of synaesthesia forms. We label these coloured sequence synaesthesias (CSSs), coloured music synaesthesias, non-visual sequela synaesthesias, spatial sequence synaesthesia (SSS), and coloured sensation synaesthesias. Collectively, our findings reveal that synaesthesia is an umbrella term that encompasses several distinct groups with independent probabilities of expression, and this may in turn suggest distinct underlying mechanisms and the possibility of different genetic bases.
Supplementary Table 4 from Tumor Subtype-Specific Cancer–Testis Antigens as Potential Biomarkers and Immunotherapeutic Targets for Cancers (2023)

&lt;p&gt;XLSX file - 34K, Supplemental Table S4. Estimated overexpression frequencies of CT genes in human cancer subtypes.&lt;/p&gt;
P13-01. Crystal structure and function of a monoclonal antibody against primate CD4 that blocks HIV/SIV infection (2009)

Background The HIV cellular receptor, CD4, is not subject to the high rate of mutation found in viral gene products. Therefore antibodies that target the gp120 binding domain of CD4 that do not interfere with its physiological role might provide an effective means to prevent HIV infection. Here, we report on the development and characterization of a CD4 antibody that blocks HIV/SIV infection by binding to the gp120 binding domain of CD4.
Protein Phosphorylation and Protein Kinase Activities in (1986)

activity with a cellular particulate fraction. In contrast to these differences, both insulin and PMA stimulated the phosphorylation of ribosomal protein S6 and activated a ribosomal protein S6 kinase in cell-free extracts from cells exposed to these agents. In cells exposed to high concentrations of PMA for 16 h, protein kinase
Highly Reliable Contacts to Silicon Enabled by Low Temperature Sputtered Graphenic Carbon (2019)

Titanium silicide (TiSi) contacts are frequently used metal-silicon contacts but are known to diffuse into the active region under high current density stress pulses. Recently, we demonstrated that graphenic carbon (GC) deposited by CVD at 1000 °C on silicon has the same low Schottky barrier as TiSi, but a much improved reliability against high current density stress pulses. In this paper, we demonstrate now that the deposition of GC is possible at 100 °C - 400 °C by a sputter process. We show that the sputtered carbon-silicon contact is over 1 billion times more stable against high current density pulses than the conventionally used TiSi-Si junction, while it has the same or even a lower Schottky barrier. SC can be doped by nitrogen (CN) and this results in an even lower resistivity and improved stability. Scalability of the CN thickness down to 5 nm is demonstrated. The finding that there is a low temperature approach for using the excellent carbon properties has important consequences for the reliability of contacts to silicon and opens up the use of GC in a vast number of other applications.
Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach (2015)

We conclude that introduction of HPV16 L2 12-41 epitope into Ad5 hexon HVR1 or HVR5 is a feasible method of generating a protective HPV vaccine, but further optimization is required to strengthen the L2-specific response and broaden protection to the more diverse hrHPV.
The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells (2016)

CEP-37440 is effective against some IBC cells that express phospho-FAK1 (Tyr 397), and its antiproliferative activity is related to its ability to decrease phospho-FAK1. Our results suggest that combinational therapies could be more effective than using CEP-37440 as a single agent.
Bamboo-shaped aligned CNxnanotubes synthesized using single feedstock at different temperatures and study of their field electron emission (2008)

The present investigation deals with the synthesis of N-doped aligned bamboo-shaped carbon nanotubes (CNx) by chemical vapour deposition of monoethanolamine/ferrocene mixture on quartz substrate over the temperature range 700–900 °C. All nanotubes exhibited bamboo-like morphology with transverse carbon bridges forming compartments in this temperature range. The concentration of nitrogen content has been controlled in the range 4.8–5.8 at% by controlling the deposition temperature. Scanning electron microscopy, transmission electron microscopy (TEM)/high-resolution transmission electron microscopy (HRTEM), x-ray photoelectron spectroscopy (XPS), Raman spectroscopy and thermogravimetric analysis were used to characterize the composition and structural analysis of the as-grown nanotubes. HRTEM revealed that nanotubes prepared at high temperature with low nitrogen content have high graphitization degree. XPS analysis indicated that N 1s signal was split into three peaks. The decomposition of monoethanolamine at reaction temperature produces ammonia which may provide an efficient route of higher nitrogen content on carbon nanotubes. Field emission measurements indicated that N-doped carbon nanotubes prepared at 800 °C showed nice field emission performance with turn-on and threshold field of 1.6 and 2.3 V µm−1, respectively.
Numerical simulation of ammonia turbulent diffusion burner with hydrogen flame stabilizer (2021)

An ammonia coaxial jet diffusion flame stabilized with hydrogen was analyzed. The calculations were performed using three schemes, and the best scheme was selected by comparing the calculation and experimental results. As a result, (1) The results obtained using the Creck-Mech well agreed with the experimental results of NOx emission level and the flame structure, (2) When OH and H radicals were supplied by turbulent, a large amount of NOx was induced. Concurrently, the mixing of NO and NH3 and the reduction reaction were promoted, consequently reducing NO to N2. Therefore, arranging the reduction zone where NO can sufficiently react with N, NH, and NH2 is important in design.
481 Differences in Humoral and Cellular Immunity in Young and Old Individuals (2012)

BACKGROUND: The immune system changes with the age. In this study we characterized immune changes by performing immunologic screening profiles on aging individuals (graduation thesis). METHODS: This study was performed at Akdeniz University, in the Faculty of Medicine, Dept. of Immunology. Healthy volunteers consisted of a young group (22 donors) and an older group (45 individuals). Using flow cytometry analysis, CD3, CD4, CD8, CD16, CD19, CD28, CD40, CD45, CD56, CD80, CD86, CTLA-4 and with ELISA IL-1 β, IL-2, IL-6, IL-10, IFN-γ, TNF-α expression were evaluated, along with and NK activity and induced cytokine expression (by bioassay/ELISA respectively). RESULTS: No statistical differences were observed between the 2 groups in expression of CD3, CD8, CD19, CD80, CD86, CD16, CD 56 or CD28. A higher frequency of expression of CD4, CTLA-4, CD40 and CD45 was seen in older subjects by comparison with young subjects. Cytokine profiles expressed by stimulated monocytes from the 2 groups showed no difference in IL-1 β, IL-2, IL-6, IL-10, TNF-α and IFN-γ production levels. Cytokine profiles expressed by stimulated lymphocytes from the 2 groups showed no difference in IL-1 β, IL-2, IL-6, IL-10, TNF-α and IFN-γ production levels. CONCLUSIONS: We found increased expression levels of CD40 and CD45 levels in healthy older (>55 years old) versus young individuals (media age 28 years). CTLA-4 expression levels were also higher in elderly subjects, with no difference in CD28 expression levels between young/elderly individuals.
DOP84 Early treatment responses within 14 days of intravenous vedolizumab induction therapy for Crohn’s Disease: Post hoc analysis of patient-reported outcomes from the VISIBLE 2 study (2021)

Abstract Background Vedolizumab (VDZ), an anti-a4β7 integrin antibody that selectively blocks lymphocyte trafficking to the gut, is approved for the treatment of adult patients with moderate-to-severe Crohn’s disease (CD). This post hoc analysis of data from the VISIBLE 2 trial evaluated early patient-reported outcomes assessed within the first 14 days of VDZ induction. Methods VISIBLE 2 (NCT02611817; EudraCT 2015-000481-58) was a phase 3, multicentre, placebo-controlled study, evaluating the efficacy and safety of subcutaneous VDZ for maintenance treatment in patients with moderately to severely active CD. Efficacy was assessed based on CD Activity Index (CDAI). Patients received induction treatment with intravenous (IV) VDZ 300 mg open-label at Weeks 0 and 2. For this analysis, responses to VDZ were assessed using CDAI sub-scores for patient-reported abdominal pain (AP) and stool frequency (SF) collected daily via electronic diary in the first 14 days of VDZ treatment (Day 1 to 15) in all patients receiving ≥1 VDZ dose at induction. Descriptive statistics were used. Results The analysis included 611 patients (mean [SD] age 37.6 [13.4] years; CD duration 9.0 [8.1] years); 323 (53%) were male; 228 (37%) had severe disease (CDAI &amp;gt;330) at baseline; and 350 (57%) were anti-TNF-experienced. In the first 14 days of VDZ IV induction, the rate of patients with daily SF≤3 increased from 30% at baseline (Day 1) to 47.7% on Day 15. Increases were similar in both anti-TNF-naïve vs. anti-TNF-experienced patients and in patients with severe vs. moderate disease (Figure 1). Mean baseline SF was reduced from 6.4 to 5.0 at Day 15 in patients with severe disease and from 4.3 to 3.5 in patients with moderate disease. Overall, the proportion of patients rating AP as severe/moderate declined from baseline to Day 15 of induction (from 14.6% to 8.2% for severe AP and from 60.7% to 40.6% for moderate AP). Similar Day 1-to-15 reductions were reported in both anti-TNF-naïve (severe AP: 14.2% to 9.2%; moderate AP: 62.6% to 44.6%) and anti-TNF-experienced patients (severe AP: 14.8% to 7.4%; moderate AP: 59.3% to 37.7%), respectively. Although a minority of patients (6.3%) in the sub-group with moderate AP at baseline had worse pain at Day 15, there were early improvements in AP ratings for most patients reporting severe or moderate AP at baseline (Figure 2). Conclusion This post hoc analysis of daily patient-reported SF and AP in the VISIBLE 2 CD study indicates an early onset of response to VDZ IV induction within the first 14 days of treatment.
First detection and genome sequencing of SARS‐CoV‐2 in an infected cat in France (2020)

After its first description in Wuhan (China), SARS-CoV-2 the agent of coronavirus disease 2019 (COVID-19) rapidly spread worldwide. Previous studies suggested that pets could be susceptible to SARS-CoV-2. Here, we investigated the putative infection by SARS-CoV-2 in 22 cats and 11 dogs from owners previously infected or suspected of being infected by SARS-CoV-2. For each animal, rectal, nasopharyngeal swabs and serum were taken. Swabs were submitted to RT-qPCR assays targeting 2 genes of SARS-CoV-2. All dogs were tested SARS-CoV-2 negative. One cat was tested positive by RT-qPCR on rectal swab. Nasopharyngeal swabs from this animal were tested negative. This cat showed mild respiratory and digestive signs. Serological analysis confirms the presence of antibodies against the SARS-CoV-2 in both serum samples taken 10 days apart. Genome sequence analysis revealed that the cat SARS-CoV-2 belongs to the phylogenetic clade A2a like most of the French human SARS-CoV-2. This study reports for the first time the natural infection of a cat in France (near Paris) probably through their owners. There is currently no evidence that cats can spread COVID-19 and owners should not abandon their pets or compromise their welfare.
Hardware‐efficient phase‐detection technique for digital clock and data recovery (2013)

A phase‐detection technique for digital clock and data recovery (CDR) in multi‐Gbit/s serial links is presented. Compared to conventional sampling‐based receivers, hardware efficiency at the system‐level is achieved by extracting timing information from analysing the occurrence of certain patterns at the output of four comparators. The arrangement of the decision threshold and sampling time of these comparators is discussed, and the phase and frequency detection characteristic of such an arrangement is evaluated. The technique is validated through a proof‐of‐concept 12.5 Gbit/s CDR chip that is fabricated in 90nm CMOS.
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the embryo uncertain. Here, we avoided using feeder cells or serum factors to provide a defined culture microenvironment. We show that the combination of activin A, fibroblast growth factor and the Wnt inhibitor XAV939 (AFX) supports establishment and continuous expansion of pluripotent stem cell lines from porcine, ovine and bovine embryos. Germ layer differentiation was evident in teratomas and readily induced in vitro. Global transcriptome analyses highlighted commonality in transcription factor expression across the three species, while global comparison with porcine embryo stages showed proximity to bilaminar disc epiblast. Clonal genetic manipulation and gene targeting were exemplified in porcine stem cells. We further demonstrated that genetically modified AFX stem cells gave rise to cloned porcine foetuses by nuclear transfer. In summary, for major livestock mammals, pluripotent stem cells related to the formative embryonic disc are reliably established using a common and defined signalling environment. This article has an associated 'The people behind the papers' interview.
4‐Phenyl‐4H‐pyrans as IKCa Channel Blockers. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Polymer‐based cell‐free expression of ligand‐binding family B G‐protein coupled receptors without detergents (2011)

G-protein coupled receptors (GPCRs) constitute the largest family of intercellular signaling molecules and are estimated to be the target of more than 50% of all modern drugs. As with most integral membrane proteins (IMPs), a major bottleneck in the structural and biochemical analysis of GPCRs is their expression by conventional expression systems. Cell-free (CF) expression provides a relatively new and powerful tool for obtaining preparative amounts of IMPs. However, in the case of GPCRs, insufficient homogeneity of the targeted protein is a problem as the in vitro expression is mainly done with detergents, in which aggregation and solubilization difficulties, as well as problems with proper folding of hydrophilic domains, are common. Here, we report that using CF expression with the help of a fructose-based polymer, NV10 polymer (NVoy), we obtained preparative amounts of homogeneous GPCRs from the three GPCR families. We demonstrate that two GPCR B family members, corticotrophin-releasing factor receptors 1 and 2β are not only solubilized in NVoy but also have functional ligand-binding characteristics with different agonists and antagonists in a detergent-free environment as well. Our findings open new possibilities for functional and structural studies of GPCRs and IMPs in general.