gebhart/patrepeval huggingface dataset:
Weight Gain–Induced Blood Pressure Elevation (2000)

This study was conducted to evaluate the mechanisms in weight gain-induced blood pressure (BP) elevation focusing, in particular, on the contributions of sympathetic nervous system activity, fasting plasma insulin, and leptin to BP levels. The study design was longitudinal with a cohort of 1897 men. BP, pulse rate, body mass index (BMI), fasting plasma norepinephrine (NE), insulin, and leptin were measured at 6 and 12 months in those 172 lean normotensive, 79 obese normotensive, 64 lean untreated hypertensive, and 38 obese untreated hypertensive men whose BMI increased >10% during the first 6 months. At entry, levels of BP, pulse rate, plasma NE, insulin, and leptin in obese subjects, regardless of BP status, were significantly greater than those in lean subjects. The levels of plasma NE, insulin, and leptin increased with weight gain in the 4 study groups. In the subjects with BP elevation, the increase in pulse rate and plasma NE was significantly greater than that in the subjects without BP elevation at both 6 and 12 months for each of the 4 study groups, although the increase in BMI was similar between the subjects with and without BP elevation. In obese but not lean subjects, whether normotensive or hypertensive, the increases in plasma insulin and plasma leptin with weight gain were greater in the subjects with accompanying BP elevation compared with the subjects without BP elevation. On the other hand, at 6 months in lean subjects, the increase in plasma insulin with weight gain in the subjects with BP elevation was actually lower than that in the subjects without BP elevation. These results suggest that weight gain-induced sympathetic overactivity is more tightly linked to weight gain-induced BP elevation than the changes in plasma insulin and leptin that also accompany weight gain. It is probable that sympathetic nervous activation with weight gain is a major mechanism of blood pressure elevation. Hyperinsulinemia and hyperleptinemia may be ancillary factors that contribute to sympathetic nervous stimulation with weight gain.
Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection (2016)

Cryptococcus neoformans (Cn) and Histoplasma capsulatum (Hc) co-exist in the environment and occasionally co-infect individuals, which can lead to severe disease/lethal outcomes. We investigated specific interactions between Cn-Hc to determine the impact of synchronous infection in virulence and disease. Co-infected mice had significantly higher mortality than infection with either species or acapsular Cn-Hc. Coating of Hc with cryptococcal glycans (Cn-gly) resulted in higher pulmonary fungal burden in co-infected animals relative to control. Co-cultivation or addition of Cn-gly resulted in enhanced pellicle formation with a hybrid polysaccharide matrix with higher reactivity to GXM mAbs. Transfer and incorporation of Cn polysaccharide onto Hc surface was time and temperature dependent. Cn-gly transfer altered the zeta potential of Hc and was associated with increased resistance to phagocytosis and killing by macrophages. Mice infected with Hc and subsequently injected with purified Cn-gly died significantly more rapidly than Hc alone infected, establishing the precedent that virulence factors from one fungus can enhance the virulence of unrelated species. These findings suggest a new mechanism of microbial interaction involving the transfer of virulence traits that translates into enhanced lethality during mixed fungal infections and highlights the importance of studying heterogeneous microbial populations in the setting of infection.
Atrial Arrhythmia After a First Atrial Fibrillation Ablation: What is the mechanism? (2007)

Case Reports
High-resolution anamorphic SPECT imaging (2012)

We have developed a gamma-ray imaging system that combines a high-resolution silicon detector with two sets of movable, half-keel-edged copper-tungsten blades configured as crossed slits. These apertures can be positioned independently between the object and detector, producing an anamorphic image in which the axial and transaxial magnifications are not constrained to be equal. The detector is a 60 mm × 60 mm, one-millimeter-thick, one-megapixel silicon double-sided strip detector with a strip pitch of 59 μm. The flexible nature of this system allows the application of adaptive imaging techniques. We present system details; calibration, acquisition, and reconstruction methods; and imaging results.
Factorizing complex predicates in queries to exploit indexes (2003)

Decision-support applications generate queries with complex predicates.We show how the factorization of complex query expressions exposes significant opportunities for exploiting available indexes.We also present a novel idea of relaxing predicates in a complex condition to create possibilities for factoring.Our algorithms are designed for easy integration with existing query optimizers and support multiple optimization levels, providing different trade-offs between plan complexity and optimization time.
Has the Time for In silico Design of Nanomedicines Finally Arrived? (2011)

Cancer therapy and diagnostics are among the most appealing and well-studied applications of nanomedicine (a recent PubMed query of delivery+ returned over 2,400 hits). Targeted drug delivery is based on the notion that nanoparticles (NPs) could be designed to overcome chemotherapy's systemic toxicity by specifically penetrating tumor tissue and delivering drugs directly to the cancer cells. The delivery of medications to a majority of cells at the primaryand metastatic sites is of critical importance to the success of such chemotherapeutics. However, as noted recently by Bae and Park in their excellent recent perspective in the Journal of Controlled Release [1], efficieint delivery of these drugs to tumors has yet to be achieved. The authors provide multiple reasons for the lack of success of targeted NPs, including: 1. Tumor heterogeneity; 2. Tumor penetration and diffusion problems; 3. An insufficient number of targetable cell receptors; 4. Unfavorable nanoparticle pharmacokinetics, where >95% of the injected dose is wasted due to NP uptake by immune organs. How are we to solve these apparently challenging problems? One potential approach is that of the Ruoslahti and Tuveson groups, which recently used Hedgehog inhibitors [2] and Neuropilin-1 agonists [3] to improve tumor penetration by exploiting biological mechanisms. These strategies resulted in a remarkable enhancement of tumor penetration by NPs and drugs. Similarly, cancer genomics and proteomics provide enormous amounts of information on tumor markers and receptors, which could be exploited for targeting multiple populations inside the tumor, including tumor macrophages, stromal cells, and stem cells. Significant progress has been made in understanding the interactions of NPs with the biological milieu and the effect of these interactions on the clearance of nanoparticulates.
Enhanced performance of nitride-based ultraviolet vertical-injection light-emitting diodes by non-insulation current blocking layer and textured surface (2014)

For the purpose of light extraction and efficiency enhancement, the nitride-based ultraviolet vertical-injection light-emitting diodes (UV-VLEDs) with non-insulation current blocking layer (n-CBL) and optimized textured surface were fabricated. The optical and electrical characteristics were investigated in this n-CBL UV-VLED. Furthermore, the efficiency of optimized structure was improved by 5 ~ 6 times compared to our reference.
Therapeutic Impact of Follistatin-Like 1 on Myocardial Ischemic Injury in Preclinical Models (2012)

Our data indicate that FSTL1 can prevent myocardial ischemia/reperfusion injury by inhibiting apoptosis and inflammatory response through modulation of AMP-activated protein kinase- and bone morphogenetic protein-4-dependent mechanisms, suggesting that FSTL1 could represent a novel therapeutic target for post-myocardial infarction, acute coronary syndrome.
A wireless microsensor for monitoring flow and pressure in a blood vessel utilizing a dual-inductor antenna stent and two pressure sensors (2004)

This paper reports a micromachined antenna stent (stentenna) that is integrated with implantable microsensors for wireless sensing of blood flow and pressure with no battery. A device that has 20-mm length and 3.5-mm diameter (after expansion) is fabricated from 50 /spl mu/m thick stainless steel foil by using batch-compatible micro-electro-discharge machining. This is coupled to two micromachined capacitive pressure sensors of approximately 1.4/spl times/1.8/spl times/0.5 mm/sup 3/ dimensions. A 0.5-/spl mu/m thick parylene layer provides electrical insulation. The integrated device is deployed inside a silicone mock artery with a standard angioplasty balloon. The planar structure is plastically deformed to a tubular shape, resulting in dual helical coils with 50-60 nH each. These L-C tanks are used to wirelessly probe pressures at two points along a channel for flow-rate detection. Fluidic experiments that emulate a blockage in the mock artery demonstrate that the resonant impedance and phase provided by the LC-tanks to a separate transmitting coil shift by 5-40 MHz over flow-rate change of 150-300 mL/min. Pressure sensitivity is 273 ppm/Torr, which is >100/spl times/ higher than past results.
SAST for JavaScript: A Brief Overview of Commercial Tools (2014)

Static application security testing (SAST) is a widely used technique that helps to find security vulnerabilities in program code at an early stage in the software development life-cycle. Since a few years, JavaScript is gaining more and more popularity as an implementation language for large applications. Consequently, there is a demand for SAST tools that support JavaScript.We report briefly on our method for evaluating SAST tools for JavaScript as well as summarize the results of our analysis.
Ku-Band Power Amplifier MMIC Chipset with On-Chip Active Gate Bias Circuit (2009)

We propose a Ku-band driver and high-power amplifier monolithic microwave integrated circuits (MMICs) employing a compensating gate bias circuit using a commercial 0.5 m GaAs pHEMT technology. The integrated gate bias circuit provides compensation for the threshold voltage and temperature variations as well as independence of the supply voltage variations. A fabricated two-stage Ku-band driver amplifier MMIC exhibits a typical output power of 30.5 dBm and poweradded efficiency (PAE) of 37% over a 13.5 GHz to 15.0 GHz frequency band, while a fabricated three-stage Kuband high-power amplifier MMIC exhibits a maximum saturated output power of 39.25 dBm (8.4 W) and PAE of 22.7% at 14.5 GHz.
Acoustic-Convective Interference in Transfer Functions of Methane/Hydrogen and Pure Hydrogen Flames (2021)

Abstract We investigate the occurrence and source of modulations in the gain and phase of flame transfer functions (FTF) measured in perfectly premixed, bluff body stabilized CH4/H2 and pure H2 flames. The modulations are shown to be caused by flow disturbances originating from the upstream geometry, in particular the grub screws used to center the bluff body, indicative of a more generalized phenomenon of convective wave propagation. Velocity measurements are performed at various locations around the injector dump plane, inside the injector pipe, and in the wake of the bluff body to provide detailed insight into the flow. Peaks corresponding to natural shedding frequencies of the grub screws appear in the unforced velocity spectra and it is found that the magnitude of these convective modes depends on their location. Flame imaging and PIV measurements show that these disturbances do not show up in the mean velocity and flame shape which appear approximately axisymmetric. However, the urms and vrms fields capture a strong asymmetry due to convective disturbances. To further quantify the role of these convective disturbances, hydrodynamic transfer functions are constructed from the forced cold flow, and similar modulations observed in the FTFs are found. A strong correlation is obtained between the two transfer functions, subsequently, the modulations are shown to be centered on the vortex shedding frequency corresponding to the first convective mode. The reason behind the excitation of the first mode is due to a condition that states that for acoustic-convective interaction to be possible, the shedding (convective) frequency needs to be lower than the cutoff frequency of the flame response. This condition is shown to be more relevant for hydrogen flames compared to methane flames due to their shorter flame lengths and thus increased cutoff frequency.
Data from Integration of Host-Related Signatures with Cancer Cell–Derived Predictors for the Optimal Management of Anticancer Chemotherapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Current cancer management aims to integrate molecular signatures into the design of personalized therapies. Recent advances in “omics” done on tumor specimens have led to the identification of factors that either recognize cancers of dismal prognosis or pinpoint “druggable” signaling pathways, which can be interrupted by targeted therapies. However, accumulating evidence underscores the biological and clinical significance of immune predictors in several compartments (blood, serum, tumor) in a variety of malignancies. An additional aspect that has been overlooked is the bidirectional, tumor-host interaction during therapeutic intervention, suggesting that dynamic molecular, biochemical, and metabolic signatures should be developed in the future. We review immune parameters of prognostic or predictive value during cancer therapy, and highlight existing “descriptive-prognostic” and “functional-therapeutic” molecular signatures, with the hindsight of designing appropriate compensatory therapies. &lt;i&gt;Cancer Res; 70(23); 9538–43. ©2010 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Silicone intraocular lens resolution in air and in water (1988)

The resolution efficiencies of 31 biconvex silicone intraocular lenses, ranging in power from 16.0 to 23.5 diopters, were tested in air and in water to see if a predictable relationship existed as previously reported with polymethylmethacrylate lenses. Resolution efficiency is defined as the percentage ratio of the actual resolving power of a lens to that of a perfect lens of the same focal length which is only limited in resolution by diffraction. The lenses ranged from 29% to 58% resolution efficiency in air. No lenses exhibiting multiple images were included. All 31 lenses achieved at least 73% resolution efficiency in water, and one lens achieved 82%. Based on these findings, a biconvex silicone lens that exceeds 30% resolution efficiency in air and does not produce multiple images can perform near its diffraction limit when implanted in the eye.
Challenges Toward Wireless Communications for High-Speed Railway (2014)

High-speed railway (HSR) brings convenience to peoples' lives and is generally considered as one of the most sustainable developments for ground transportation. One of the important parts of HSR construction is the signaling system, which is also called the “operation control system,” where wireless communications play a key role in the transmission of train control data. We discuss in detail the main differences in scientific research for wireless communications between the HSR operation scenarios and the conventional public land mobile scenarios. The latest research progress in wireless channel modeling in viaducts, cuttings, and tunnels scenarios are discussed. The characteristics of nonstationary channel and the line-of-sight (LOS) sparse and LOS multiple-input-multiple-output channels, which are the typical channels in HSR scenarios, are analyzed. Some novel concepts such as composite transportation and key challenging techniques such as train-to-train communication, vacuum maglev train techniques, the security for HSR, and the fifth-generation wireless communications related techniques for future HSR development for safer, more comfortable, and more secure HSR operation are also discussed.
Network and service architecture for emerging services based on home sensor networks (2009)

Sensor networks in the home can enable a variety of applications such as home monitoring and control, home security, home energy management, and home health care. Current state-of-the-art solutions typically target a single sensor application and do not take advantage of the established infrastructure of the broadband service provider, such as a telco operator or cable provider. In this paper, we propose an alternative solution that provides a comprehensive and scalable service platform for multiple parallel home sensor applications, even from third party providers. We highlight the advantages that a broadband service provider holds for providing these emerging high margin services, and derive a suitable end-to-end network architecture. We describe the functions of each of the main components and some of their interfaces, and pay particular attention to one of the key technological challenges: the commissioning and management of the home sensor network. In particular, we describe a laboratory implementation that demonstrates the feasibility of automatic commissioning and remote management of the sensor network.
ChemInform Abstract: Matrix Isolation Infrared and Density Functional Theoretical Studies of Organic Silanones, (CH3O)2Si=O and (C6H5)2Si=O. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>Acousto-optic estimation of autocorrelation and spectra using triple correlations and bispectra</title> (1991)

Nonparametric estimation of lower-order statistics from higher-order statistics of continuous processes is considered. Of particular interest is estimation of correlations and spectra (second-order statistics) from higher-order correlations and polyspectra (higher-order statistics). The use of higher-order statistics is motivated by their insensitivity to a wide class of additive noises including Gaussian noise of unknown covariance. The fact that lower-order correlations are projections of higher-order correlations is exploited. Experimental results are presented using an acousto-optic triple product processor to estimate the autocorrelation of a 1- D signal.
Organoosmium Oxides: Efficient Syntheses and Structures (1990)

Not only the hitherto simplest alkylosmium oxide, Me4OsO, which is stable in the gas phase, and whose structure (figure on the right) can elucidated by electron diffraction analysis, but also the thermolabile Et4OsO and a mixed alkylated derivative could be prepared good yields. In addition, the structurally novel trimer [{(py)OsO2Me2}3] with planar Os3O3 six-membered ring is reported.
Biological Activities of Carbohydrate-Branched Chitosan Derivatives (2001)

Two types of biological activities of the carbohydrate-branched chitosan derivatives were investigated. One is the specific interaction with lectins and bacterium. The other is activation of canine polymorphonuclear leukocyte (PMN) cells. The specific bindings of the L-fucose-branched chitosan derivative with Ulex europaeus agglutinin I (UEA-I) and the N-acetyl-D-glucosamine-branched chitosan derivative with Concanavalin A (Con A) were confirmed by a surface plasmon resonance technique. The specific aggregation of the fluorescence-labeled L-fucose-branched chitosan derivative with Pseudomonas aeruginosa was observed by fluorescent microscopic observation. The aggregation would be attributed to the specific binding between the L-fucose-branched chitosan derivative and PA-II receptor on the cell surface of P. aeruginosa. The influence of the chitosan derivatives on the active oxygen species generation from canine PMN cells was also investigated by the luminol-aided chemiluminescence method. The chemiluminescence responses depended on the degree of substitution and water solubility of the chitosan derivatives. The water-insoluble chitosan derivatives would stimulate the PMN cells by a phagocytosis mechanism, and the water-soluble ones would sensitize the PMN cells by a priming mechanism.
Neuron-MOS continuous-time winner-take-all circuit for intelligent data processing (2002)

A unique circuit architecture has been developed for winner-take-all (WTA) circuits operating in continuous time using neuron-MOS (/spl nu/MOS) technology. The /spl nu/MOS WTA identifies the location of the winner as an oscillating node of a multiple-loop /spl nu/MOS ring oscillator. The nonoscillating mode of operation has been also obtained by a proper design of delay elements. High accuracy search for the winner has been achieved by the introduction of a new digital/analog merged feedback control. The circuit operation has been demonstrated and all verified by test circuits fabricated by double-polysilicon CMOS processes.
Local characterization of vapor-deposited electrode edges in thin film organic electronic devices (2007)

Scanning probe microscopy was used to characterize the shadow-mask-edge profiles formed during the vapor deposition of aluminum electrodes onto semiconducting polymer (poly-4,4′-4″-n-hexyl-triphenylamine) and gold substrates. Simultaneous topography and surface potential (Kelvin probe) imaging revealed a mask-edge profile with structure extending over a region much wider than the geometric penumbra behind the mask. The images of Al on polymer are interpreted in terms of an overlayer that is morphologically indistinguishable, but chemically distinct, from the polymer surface. On gold, a perforated granular metallic surface reveals coupled diffusion and kinetic processes that are consistent with growth of Al:Au intermetallic phases and void formation due to the faster diffusion of Al relative to Au, i.e., the Kirkendall effect.
Is the Mucosal Route of Administration Essential for Probiotic Function? Subcutaneous Administration is Associated with Attenuation of Murine Colitis and Arthritis (2004)

Background: We, and others have reported the prophylactic efficacy of oral consumption of probiotic lactobacilli in the IL-10 KO model of colitis. It has not been demonstrated that the oral route is essential for probiotic efficacy.
A sensitive monoclonal antibody‐based enzyme‐linked immunosorbent assay to quantify Parietaria judaica major allergens, Par j 1 and Par j 2 (2005)

The results proved the usefulness of the two-sandwich ELISA for the standardization of Parietaria pollen extracts intended for clinical use, because of its good correlation with allergenic potency.
PyZDDE: Release version 2.0.2 (2016)

See https://github.com/indranilsinharoy/PyZDDE/wiki/08.-News-and-updates