gebhart/patrepeval huggingface dataset:
Rhodium‐Catalyzed Cycloisomerization: Formation of Indoles, Benzofurans, and Enol Lactones (2007)

Internal affairs: Indoles, benzofurans, and enol lactones are formed chemoselectively from the rhodium-catalyzed cycloisomerization reaction of easily prepared alkynyl aniline substrates (see scheme, cod=cycloocta-1,5-diene, DMF=N,N-dimethylformamide). The reaction may proceed by nucleophilic capture of a vinylidene intermediate. Indoles are formed under mild conditions using low catalyst loadings. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604183_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<title>Mechanisms contributing to optimization of PDT with first-generation photosensitizers</title> (1993)

Improved control of tumor growth has been accomplished by modification of the irradiation scheme applied to hematoporphyrin-induced sensitization. Significantly enhanced efficacy of PDT was seen with either reduction of fluence rate or with an intermittent light-dark protocol, together suggesting that consideration must be given to photochemical oxygen depletion as a rate-limiting component in the production of singlet oxygen, the mediator of cytotoxicity resulting from PDT. A model to explain the basis for the improved efficacy was developed and is being tested by study of homograft and xenograft tumors in vivo and in multicellular tumor spheroids in vitro.
ChemInform Abstract: An Enantiocontrolled Synthesis of Pyrrolizidines, (‐)‐Platynecine and ( ‐)‐Hadinecine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The stimulation of pyruvate appearance in the rabbit oviduct lumen by sodium propionate (1980)

Sodium propionate stimulated the appearance of pyruvte in saline medium recirculated through the lumen of the rabbit oviduct for 4 h in vivo. The propionate was equally effective whether added to the lumen or infused into the bloodstream. The final pyruvate concentration in the lumen in the presence of propionate was 1.3 times that in the plasma. Propionate increased the pyruvate content of oviduct tissue slices incubated in vitro, indicating that a proportion of the propionate-stimulated pyruvate appearance could be due to the metabolic conversion of propionate into pyruvate.
Music Content Analysis through Models of Audition (1998)

The direct application of ideas from music theory and music signal processing has not yet led to successful musical multimedia systems. We present a research framework that addresses the limitations of conventional approaches by questioning their (often tacit) underlying principles. We discuss several case studies from our own research on the extraction of musical rhythm, timbre, harmony, and structure from complex audio signals; these projects have demonstrated the power of an approach based on a realistic view of human listening abilities. Continuing research in this direction is necessary for the construction of robust systems for music content analysis. INTRODUCTION Most attempts to build music-analysis systems have tried hard to respect the conventional wisdom about the structure of music. However, this model of music---based on notes grouped into rhythms, chords and harmonic progressions---is really only applicable to a restricted class of listeners; there is strong evid...
A Framework for Practical Universally Composable Zero-Knowledge Protocols. (2011)

Abstract. Zero-knowledge proofs of knowledge (ZK-PoK) for discrete logarithms and related problems are indispensable for practical cryptographic protocols. At Eurocrypt 2009, Camenisch, Kiayias, and Yung provided a specification language (the CKY-language) for such protocols, which allows one to modularly design and analyze cryptographic protocols: protocol designers just need to specify the statement they want to prove in zero-knowledge and are ensured that an efficient proof protocol exists and indeed proves the specified statement, provided that the specification was in the CKY-language. However, as specifications in the CKY-language are realized by so-called Σ-protocols, the resulting protocols only satisfy the classical notion of zero-knowledge proofs of knowledge, which not retained if they are composed with themselves or with other protocols, e.g., when used as building blocks for higher-level applications. This problem can be tackled by moving to the Universal Composability (UC) framework, which guarantees retention of security when composing protocols and, in particular, when using them as building blocks in arbitrary contexts. While there exists generic transformations from Σ-protocols to protocols that are secure under this stronger security notion, these transformation are often not efficient enough for the design of practical protocols. In this paper we are aiming for practically efficient ZK-PoK in the UC-framework by introducing
Quantum Control over Single Spins in Diamond (2013)

Nitrogen-vacancy (NV) centers in diamond have recently emerged as a unique platform for fundamental studies in quantum information and nanoscience. The special properties of these impurity centers allow robust, room-temperature operation of solid-state qubits and have enabled several remarkable demonstrations in quantum information processing and precision nanoscale sensing. This article reviews the recent advances in magnetic and optical manipulation of the NV center’s quantum spin and their importance for prospective applications. We discuss how quantum control of individual centers can be harnessed for the protection of NV-center spin coherence, for multiqubit quantum operations in the presence of decoherence, and for high-fidelity initialization and readout. We also discuss the progress in resonant optical control, which has led to interfaces between spin and photonic qubits and may lead to spin networks based on diamond photonics. Many of these recently developed diamond-based technologies constitute critical components for the future leap toward practical multiqubit devices.
Room-temperature synthesis of molybdenum and tungsten carbides, Mo2C and W2C, via chemical reduction methods (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRoom-temperature synthesis of molybdenum and tungsten carbides, Mo2C and W2C, via chemical reduction methodsD. Zeng and M. J. Hampden-SmithCite this: Chem. Mater. 1992, 4, 5, 968–970Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/cm00023a004https://doi.org/10.1021/cm00023a004research-articleACS PublicationsRequest reuse permissionsArticle Views637Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-term Patient Perception Following Surgery for Adolescent Idiopathic Scoliosis if Dissatisfied at 2-year Follow-up (2020)

Having a low HRQOL score 2 years after surgery for AIS does not guarantee a low score 5 years after surgery. Promisingly, most patients demonstrate some improvement in all domains for patient-reported SRS-22 scores at 5-year compared to 2-year follow-up. Understanding the longer term postoperative evolution in patient-reported outcomes may help surgeons to effectively manage and counsel patients who are dissatisfied in the short term.Level of Evidence: 3.
Dissociating sticker dynamics from chain relaxation in supramolecular polymer networks—The importance of free partner! (2017)

Associating polymers constitute a fascinating class of materials because of the richness in their rheological behavior. Their rheology is known to be mainly dictated by the nature and intrinsic stabilities of transient associations. Here, we provide a direct observation of the importance of free associating sites in the macroscopic relaxation of supramolecular networks constructed from ultrahigh molecular weight polymers with sparsely distributed stickers of finite functionality. Their rheological signature affords evidence that the macroscopic relaxation of supramolecular networks can be apparently dissociated from the intrinsic lifetime of the associating units, provided that diffusion processes do not lead to successful chain relaxation at the microscopic level.
Autonomous laser diagnostics system for optical heterodyne frequency-shift-keyed communication systems (1987)

This paper describes an autonomous diagnostics system for the laser transmitter in an optical heterodyne frequency-shift-keyed (FSK) communication system. The system uses a Ne-filled discharge device and a static Fabry-Perot interferometer (Fig. 1) in conjunction with simple electronics and algorithms to set transmitter wavelength and the spacing between FSK tones.
Impact of intermediate BEOL technology on standard cell performances of 3D VLSI (2016)

While the 3D sequential process is still under development, the electrical influence of specific process for the bottom tier needs to be studied. As another MOS transistor layer is fabricated on top of the bottom one, contamination risk and thermal stability issues appear, thus requiring adaptation of conductors/dielectrics for intermediate Back-End Of Line (iBEOL) processing. As materials differ from usual copper/low-k, it is necessary to study how standard cells electrical characteristics will be affected. We modeled different descriptions of iBEOL in 14nm FDSOI process and simulated standard cells characteristics. The average power consumption is almost the same while large cells with high drive timing degradation can be up to 20% in the worst case. This sensitivity analysis allowed us to identify which parameters (permittivity, resistivity) have the greatest impact depending on standard cell type and provide technology and design guidelines. Our goal here was to limit the performance degradation to around 5% maximum for the bottom tier standard cells.
Attosecond measurement of fiber-optic chromatic dispersion by white-light interferometry (1995)

The capability offered by the low-coherence interferometry in the measurement of extremely small-optical path changes is well recognized.1 This technique is at the basis of attosecond chromatic-dispersion measurements. Figure 1 reports the realized optical circuit.2 Light from a superluminescent source is coupled to the fiber under test (FUT). The FUT is finished by two reflective splices and acts as a Fabry-Perot cavity. This cavity presents an optical-path unbalance that is fully compensated by the fiber-loop insert into the Mach-Zehnder cavity set in the receiver apparatus. When the compensating loop is kept in quiet conditions, any optical-path change in the FUT causes a fringe-shift that is measurable after C2. The double-cavity structure guarantees that any other optical-path change caused by the leading fiber is not revealed. In other words, the FUT is completely isolated from the unwanted perturbations. To increase the phase-reading precision, a carrier at frequency fc is provided by an acousto-optic modulator. The dispersion is measured by using four bandpass optical filters whose center wavelength spans the source spectrum and by reading the interference through the filters. As an example, consider the first two filters, F1 and F2. The same interference signal, coming from the coupler C2, is read with a different phase after the two filters because of the different center wavelengths. This difference in phase gives the measurement of the group velocity in the considered spectrum region. A symmetric measurement is performed in the source complementary spectrum region by the other two filters, F3 and F4. The difference between the two readings is, by definition, the measurement of the dispersion (in units of phase) in the considered spectrum zone.
Characterization of a Radiolabeled Small Molecule Targeting Leukocyte Function–Associated Antigen-1 Expression in Lymphoma and Leukemia (2006)

The radiolabeled DOTA-butylamino-NorBIRT may have potential as a noninvasive imaging or therapeutic agent in both human and mouse models.
Effect of NO Annealing on 6H- and 4H-SiC MOS Interface States (2010)

The electrical properties of the SiC/SiO2 interface resulting from oxidation of the n-type 6H-SiC polytype were studied by hi-lo CV, temperature dependent CV and constant capacitance deep level transient spectroscopy (CCDLTS) techniques. Several trap species differing in energy and capture cross section were identified. A trap distribution at 0.5 eV below the 6H-SiC conduction band energy and a shallower density of states in both the 6H and 4H polytyes are passivated by post-oxidation NO annealing. However, other ultra-shallow and deeper defect distributions remain after nitridation. The latter may originate from semiconductor traps.
Rotation-invariant, time-integrating optical correlation recognition system (1990)

The speed at which one or more targets can be recognized in a time-sequencing rotation-invariant binary phase-only filter (BPOF) optical recognition system can be improved significantly by integrating sequential correlation responses and using the integrated peak responses as inputs to the same statistical correlation plane filter (CPF) used for individual sequential correlation responses. Since commercially available BPOFs can be written at very high frame rates (350 frames per second), more than 10 correlation responses can be integrated during the frame time of an output camera operating at video rates. Therefore, the use of of integrated rather than individual sequential correlation responses reduces the processing time by a factor of 10 or more if the same standard video rate camera is used at the correlation plane. This paper presents results obtained using a prototype time-integrating BPOF correlator to achieve near real-time rotation-invariant recognition of both single and multiple targets in a noisy and cluttered input scene.
Anticalin® Proteins as Therapeutic Agents in Human Diseases (2018)

Anticalin proteins are an emerging class of clinical-stage biopharmaceuticals with high potential as an alternative to antibodies. Anticalin molecules are generated by combinatorial design from natural lipocalins, which are abundant plasma proteins in humans, and reveal a simple, compact fold dominated by a central β-barrel, supporting four structurally variable loops that form a binding site. Reshaping of this loop region results in Anticalin proteins that can recognize and tightly bind a wide range of medically relevant targets, from small molecules to peptides and proteins, as validated by X-ray structural analysis. Their robust format allows for modification in several ways, both as fusion proteins and by chemical conjugation, for example, to tune plasma half-life. Antagonistic Anticalin therapeutics have been developed for systemic administration (e.g., PRS-080: anti-hepcidin) or pulmonary delivery (e.g. PRS-060/AZD1402: anti-interleukin [IL]-4-Rα). Moreover, Anticalin proteins allow molecular formatting as bi- and even multispecific fusion proteins, especially in combination with antibodies that provide a second specificity. For example, PRS-343, which has recently entered clinical-stage development, combines an agonistic Anticalin targeting the costimulatory receptor 4-1BB with an antibody directed against the cancer antigen human epidermal growth factor receptor 2 (HER2), thus offering a novel treatment option in immuno-oncology.
A study of priority pricing in multiple service class networks (1991)

We study the role of pricing policies in multiple service class networks.
Optical memory in copper(1+)-doped .beta."-alumina (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical memory in copper(1+)-doped .beta."-aluminaGary. Hollingsworth, James D. Barrie, Bruce. Dunn, and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 1988, 110, 19, 6569–6570Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ja00227a051https://doi.org/10.1021/ja00227a051research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figures 1 - 4 from HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade (2023)

&lt;p&gt;Supplemental Figure 1. HDAC inhibition upregulates PD-L1 in a melanoma cell line in a dose dependent manner. Supplemental Figure 2. DNA methyltransferase (DNMT) inhibitors increase PD-L1 and PD-L2 expression in melanoma. Supplemental Figure 3. Verification of patient melanomas. Supplemental Figure 4. In vivo LBH589 toxicity assessment.&lt;/p&gt;
Oil Biodegradation and Oil-Degrading Microbial Populations in Marsh Sediments Impacted by Oil from the Deepwater Horizon Well Blowout (2015)

To study hydrocarbon biodegradation in marsh sediments impacted by Macondo oil from the Deepwater Horizon well blowout, we collected sediment cores 18-36 months after the accident at the marshes in Bay Jimmy (Upper Barataria Bay), Louisiana, United States. The highest concentrations of oil were found in the top 2 cm of sediment nearest the waterline at the shorelines known to have been heavily oiled. Although petroleum hydrocarbons were detectable, Macondo oil could not be identified below 8 cm in 19 of the 20 surveyed sites. At the one site where oil was detected below 8 cm, concentrations were low. Residual Macondo oil was already highly weathered at the start of the study, and the concentrations of individual saturated hydrocarbons and polycyclic aromatic hydrocarbons continued to decrease over the course of the study due to biodegradation. Desulfococcus oleovorans, Marinobacter hydrocarbonoclasticus, Mycobacterium vanbaalenii, and related mycobacteria were the most abundant oil-degrading microorganisms detected in the top 2 cm at the oiled sites. Relative populations of these taxa declined as oil concentrations declined. The diversity of the microbial community was low at heavily oiled sites compared to that of the unoiled reference sites. As oil concentrations decreased over time, microbial diversity increased and approached the diversity levels of the reference sites. These trends show that the oil continues to be biodegraded, and microbial diversity continues to increase, indicating ongoing overall ecological recovery.
Capacity gains from pilot cancellation in CDMA networks (2004)

Common pilot cancellation in mobile receivers has recently gained attention for CDMA cellular networks. This paper presents system simulation results showing that the network capacity gains achievable from both ideal and hardware resource limited pilot cancellation receivers are significant. We show that the highest gains are achievable from both ideal and hardware resource limited pilot cancellation receivers are significant. We show that the highest gains are achieved for networks populated with high rate data users, rather than voice users. We also pay special attention to the interaction between pilot cancellation and soft handoff in a power controlled network. We show that pilot cancellation allows the network to operate with fewer mobiles in soft handoff, hence reducing network signaling overhead and infrastructure costs.
Abstract 2621: Growth hormone receptor antagonist sensitizes melanoma and hepatocarcinoma to drug treatments via downregulation of ABC transporters in vivo (2022)

Abstract Knockdown of the growth hormone receptor (GHR) in melanoma cells downregulates ATP-binding cassette (ABC) transporters and sensitizes them to multiple drug treatments in vitro. The goal for this study is to understand whether a GHR antagonist (GHA) could suppress different types of cancers by sensitizing tumors to drug treatments in vivo through the downregulation of ABC transporters. Sera from GHA transgenic mice inhibited the proliferation of mouse melanoma cells (B16F10) in culture and suppressed expression of multiple ABC transporters. When B16-F10 cells were intradermally inoculated into GHA mice, tumor size was markedly reduced, as was STAT5 activation and ABCG1, ABCG2 levels. We then tested the effect of the GHA on the efficacy of cisplatin in vivo. GHA sensitized melanomas to cisplatin, leading to the smallest tumors among all groups. GHKO mice showed the same effect. We further extended this investigation to hepatocellular carcinoma (HCC). GHA mice were subcutaneously inoculated with mouse HCC (Hepa1 6 cells) and subsequently treated with sorafenib. The HCC tumors in GHA mice were markedly sensitive to sorafenib treatment compared to the same in wild-type mice. RNA analysis showed that when HCC was exposed to the combined treatment, relatively decreased ABC transporters expression was found. Immunohistochemical staining showed that phosphorylation of STAT5 and ABCB1 were downregulated in HCC tissues, suggesting that GHA in vivo downregulates ABC transporters in HCC, and therefore sensitizes them to sorafenib. Clinical data derived from HCC patients using the TCGA database showed that multiple ABC transporters in both types of cancer correlate with GHR levels; that is, when GHR levels are relatively high, patient survival is significantly decreased. Additionally, higher ABCC1 levels also lead to significantly decreased survival rate in HCC patients. Collectively, the results indicate that a GHA is effective in sensitizing both melanoma and HCC to available treatments in vivo and may be used as a therapeutic strategy for higher efficacy of tumor clearance. Citation Format: Yanrong Qian, Reetobrata Basu, Samuel Mathes, Prateek Kulkarni, Emily Davis, Darlene Berryman, Edward List, Silvana Duran, John J. Kopchick. Growth hormone receptor antagonist sensitizes melanoma and hepatocarcinoma to drug treatments via downregulation of ABC transporters in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2621.