gebhart/patrepeval huggingface dataset:
Pharmacokinetics and safety profile of intramuscular administration of allopregnanolone in patients with Alzheimer’s disease (2020)

Abstract Background Allopregnanolone (Allo) is a novel regenerative therapeutic that also reduces the burden of Alzheimer’s disease (AD) pathology. We have previously established safety, tolerability and a pharmacokinetic profile of Allo administered intravenously in AD patients. In this phase 1b trial, we assess the safety, tolerability and pharmacokinetics of Allo administered via an intramuscular injection in patients with AD. Method An open label, multiple ascending dose, phase 1b clinical trial was conducted in patients ranging from mild cognitive impairment due to AD to moderate AD. Men and women age ≥ 55 years, with a MMSE score ≥10 were recruited to the study. Patients had previously participated in the phase 1 study of Allo administered IV. Participants received weekly intramuscular injections with a dose escalation regimen of 4, 8, 12 and 16mg of Allo. Blood was collected before the injection and after at the following timepoints: 5, 15, 30, 45 minutes; 1, 2, and 4 hours. Primary outcomes included safety and tolerability parameters. Secondary endpoints included PK parameters: t max (time to reach maximum plasma concentration), C max (maximum plasma concentration), AUC 0‐last (area under the plasma concentration‐time curve from time zero to time of the last measured concentration above the limit of quantification), AUC 0‐inf (area under the plasma concentration‐time curve from zero to infinity), t ½ (terminal elimination half‐life).This is part of an IV to IM bridging study to determine the IM formulation dose that is equivalent to the IV Allo dosing (Clinicaltrials.gov: NCT03748303). Result A total of 6 participants have completed the pharmacokinetic assessment. Injection was well tolerated and did not elicit adverse events. Pharmacokinetic profile indicates direct rank order and near dose proportionality for both T max and AUC inf. Second group dosing and study procedures are currently underway. Conclusion Intramuscular administration of allopregnanolone was well tolerated, and did not elicit adverse effects in the initial cohort. Pharmacokinetic profile indicates direct rank order and near dose proportionality for both T max and AUC inf. Acknowledgments: Alzheimer’s Association Part The Cloud, Alzheimer’s Drug Discovery Foundation.
The davDT Operon of Pseudomonas putida , Involved in Lysine Catabolism, Is Induced in Response to the Pathway Intermediate δ-Aminovaleric Acid (2004)

Pseudomonas putida KT2440 is a soil microorganism that attaches to seeds and efficiently colonizes the plant's rhizosphere. Lysine is one of the major compounds in root exudates, and P. putida KT2440 uses this amino acid as a source of carbon, nitrogen, and energy. Lysine is channeled to delta-aminovaleric acid and then further degraded to glutaric acid via the action of the davDT gene products. We show that the davDT genes form an operon transcribed from a single sigma70-dependent promoter. The relatively high level of basal expression from the davD promoter increased about fourfold in response to the addition of exogenous lysine to the culture medium. However, the true inducer of this operon seems to be delta-aminovaleric acid because in a mutant unable to metabolize lysine to delta-aminovaleric acid, this compound, but not lysine, acted as an effector. Effective induction of the P. putida P(davD) promoter by exogenously added lysine requires efficient uptake of this amino acid, which seems to proceed by at least two uptake systems for basic amino acids that belong to the superfamily of ABC transporters. Mutants in these ABC uptake systems retained basal expression from the davD promoter but exhibited lower induction levels in response to exogenous lysine than the wild-type strain.
Performance Improvements of Polarization-analyzing CMOS Image Sensor (2011)

Performance of a polarization-analyzing CMOS image sensor was improved by two kinds of technical approach. Based on the whole-angle on-chip polarizer approach, a polarization-analyzing CMOS image sensor with multiple polarization-analyzing pixel array sets was designed Using 0.35μm standard CMOS technology. The accuracy of polarization analysis was improved to σ=0.0022 deg. A performance improvement of the on-chip polarizer was also demonstrated by a new photosensor designed with 65 nm standard CMOS technology.
Developing Laminar Flow in Eccentric Annuli (1997)

Technical Briefs Developing Laminar Flow in Eccentric Annuli Maged A. I. El-Shaarawi, Maged A. I. El-Shaarawi Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Search for other works by this author on: This Site PubMed Google Scholar Habib I. Abualhamayel, Habib I. Abualhamayel Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Search for other works by this author on: This Site PubMed Google Scholar Esmail M. A. Mokheimer Esmail M. A. Mokheimer Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Maged A. I. El-Shaarawi Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Habib I. Abualhamayel Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia Esmail M. A. Mokheimer Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia J. Fluids Eng. Sep 1997, 119(3): 724-728 (5 pages) https://doi.org/10.1115/1.2819307 Published Online: September 1, 1997 Article history Received: April 29, 1996 Revised: March 25, 1997 Online: December 4, 2007
Assessment of Left Ventricular Diastolic Function Using 4-Dimensional Phase-Contrast Cardiac Magnetic Resonance (2011)

Four-dimensional phase-contrast cardiovascular magnetic resonance can differentiate between normal and abnormal diastolic flow propagation within the left ventricle.
Classical Adiabatic Annealing in Memristor Hopfield Neural Networks for Combinatorial Optimization (2020)

There is an intense search for supplements to digital computer processors to solve computationally hard problems, such as gene sequencing. Quantum computing has gained popularity in this search, which exploits quantum tunneling to achieve adiabatic annealing. However, quantum annealing requires very low temperatures and precise control, which lead to unreasonably high costs. Here we show via simulations, alongside experimental instantiations, that computational advantages qualitatively similar to those gained by quantum annealing can be achieved at room temperature in classical systems by using a memristor Hopfield neural network to solve computationally hard problems.
Scale-up of the BaTiO3 ALD Process onto 200 mm Wafer (2006)

BaTiO3 films were deposited onto 200 mm silicon wafers by Atomic Layer Deposition (ALD) from barium bis(tris(tert-butyl) cyclopentadienyl) Ba(tBu3CpH2)2, titanium methoxide Ti(OMe)4 and water H2O. The films were characterized for thickness uniformity, stoichiometry and crystallinity. The thickness non- uniformity varied from 2.7 to 6.0% with different Ba(tBu3CpH2) 2 - H2O / Ti(OMe)4 - H2O cycle ratios. The most stoichiometric films were obtained with the 5:3 and 2:1 BaO:TiO2 cycling ratios. The as-deposited films were amorphous but were crystalline after thermal annealing. The study showed that this process can be transferred from small experimental scale to large production scale wafers.
On the species status of the root-knot nematode Meloidogyne mayaguensis Rammah & Hirschmann, 1988 (2012)

Holo- and paratypes of the root-knot nematodes Meloidogyne mayaguensis Rammah & Hirschmann, 1988 and Meloidogyne enterolobii Yang & Eisenback, 1983 were morphometrically and morphologically compared. All observed female, male and second-stage juvenile morphometrical and morphological characters are identical for the two studied species. Additionally, contradictions between the original species descriptions were unravelled.The present study of holo- and paratypes confirms the taxonomical status of Meloidogyne mayaguensis as a junior synonym for Meloidogyne enterolobii.
Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABAA Receptors without Affecting Synaptic Plasticity (2023)

Neurosteroids and benzodiazepines are modulators of the GABA<sub>A</sub> receptors, thereby causing anxiolysis. Furthermore, benzodiazepines such as midazolam are known to cause adverse side-effects on cognition upon administration. We previously found that midazolam at nanomolar concentrations (10 nM) blocked long-term potentiation (LTP). Here, we aim to study the effect of neurosteroids and their synthesis using XBD173, which is a synthetic compound that promotes neurosteroidogenesis by binding to the translocator protein 18 kDa (TSPO), since they might provide anxiolytic activity with a favourable side-effect profile. By means of electrophysiological measurements and the use of mice with targeted genetic mutations, we revealed that XBD173, a selective ligand of the translocator protein 18 kDa (TSPO), induced neurosteroidogenesis. In addition, the exogenous application of potentially synthesised neurosteroids (THDOC and allopregnanolone) did not depress hippocampal CA1-LTP, the cellular correlate of learning and memory. This phenomenon was observed at the same concentrations that neurosteroids conferred neuroprotection in a model of ischaemia-induced hippocampal excitotoxicity. In conclusion, our results indicate that TSPO ligands are promising candidates for post-ischaemic recovery exerting neuroprotection, in contrast to midazolam, without detrimental effects on synaptic plasticity.
Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases (2012)

The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups.
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice (2013)

Obesity is a primary risk factor for multiple metabolic disorders. Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adverse effects. Thus, there are very few efficacious drugs available and remains a great unmet medical need for anti-obesity drugs that increase energy expenditure by acting on peripheral tissues without severe side effects. Here, we report a novel approach involving antisense inhibition of fibroblast growth factor receptor 4 (FGFR4) in peripheral tissues. Treatment of diet-induce obese (DIO) mice with FGFR4 antisense oligonucleotides (ASO) specifically reduced liver FGFR4 expression that not only resulted in decrease in body weight (BW) and adiposity in free-feeding conditions, but also lowered BW and adiposity under caloric restriction. In addition, combination treatment with FGFR4 ASO and rimonabant showed additive reduction in BW and adiposity. FGFR4 ASO treatment increased basal metabolic rate during free-feeding conditions and, more importantly, prevented adaptive decreases of metabolic rate induced by caloric restriction. The treatment increased fatty acid oxidation while decreased lipogenesis in both liver and fat. Mechanistic studies indicated that anti-obesity effect of FGFR4 ASO was mediated at least in part through an induction of plasma FGF15 level resulted from reduction of hepatic FGFR4 expression. The anti-obesity effect was accompanied by improvement in plasma glycemia, whole body insulin sensitivity, plasma lipid levels and liver steatosis. Therefore, FGFR4 could be a potential novel target and antisense reduction of hepatic FGFR4 expression could be an efficacious therapy as an adjunct to diet restriction or to an appetite suppressant for the treatment of obesity and related metabolic disorders.
Risk analysis of FORTUM’s 560 MWe net power plant retrofit to oxyfuel combustion (2011)

Through technical discussion of oxyfuel retrofit of Meri–Pori’s supercritical power plant (565 MWe net), it was recognized that a deep analysis of the risks associated with the retrofit solution would be necessary for learning more about oxycombustion technology and to clarify the actual risks. As the result of the risk analysis, it was concluded that oxyfuel retrofit and oxyfuel operation would only involve low magnitude risks. This paper describes methodology of the risk analysis and major results including mitigation methods of the risks.
Dynamics of Nanoparticle Self-Assembly into Superhydrophobic Liquid Marbles during Water Condensation (2011)

Nanoparticles adsorbed onto the surface of a drop can fully encapsulate the liquid, creating a robust and durable soft solid with superhydrophobic characteristics referred to as a liquid marble. Artificially created liquid marbles have been studied for about a decade but are already utilized in some hair and skin care products and have numerous other potential applications. These soft solids are usually formed in small quantity by depositing and rolling a drop of liquid on a layer of hydrophobic particles but can also be made in larger quantities in an industrial mixer. In this work, we demonstrate that microscale liquid marbles can also form through self-assembly during water condensation on a superhydrophobic surface covered with a loose layer of hydrophobic nanoparticles. Using in situ environmental scanning electron microscopy and optical microscopy, we study the dynamics of liquid marble formation and evaporation as well as their interaction with condensing water droplets. We demonstrate that the self-assembly of nanoparticle films into three-dimensional liquid marbles is driven by multiple coalescence events between partially covered droplets and is aided by surface flows causing rapid nanoparticle film redistribution. We also show that droplet and liquid marble coalescence can occur due to liquid-to-liquid contact or squeezing of the two objects into each other as a result of compressive forces from surrounding droplets and marbles. Irrelevant of the mechanism, coalescence of marbles and drops can cause their rapid movement across and rolling off the edge of the surface. We also demonstrate that the liquid marbles randomly moving across the surface can be captured and immobilized by hydrophilic surface patterns.
A map data watermarking using the generalized square mask (2002)

This paper presents an algorithm of watermark insertion and extraction on a vector image such as map data. Most parts of the vector image such as map data consists of an array of coordinate values. At first, the image is partitioned into blocks with the same area and every vertex coordinate value within a block is changed to a new coordinate value whose origin is at the south-west vertex of the mask belongs to the associated block. According to the value of the watermark, the insertion area is different. Unlike the work by Sakamoto et al (2000), the authors may be able to use an arbitrary size of the square mask. The mask of the Sakamoto et al.'s work is specific since the length of the mask is 2/sup R/-1 where R=1, 2, ..., n. The authors also show that their method is superior to the previous work against noise attack.
Identification of novel α-gliadin genes (2011)

Ten novel α-gliadin genes (Gli-ta, Gli-turg1, Gli-turg2, Gli-turg3, Gli-turg4, Gli-turg5, Gli-turg6, Gli-cs1, Gli-cs2, and Gli-cs3) with unique characteristics were isolated from wheat (Triticum aestivumL.), among which Gli-cs1, Gli-cs2, Gli-cs3, and Gli-turg6 were pseudogenes. Gli-cs3 and nine other sequences were much larger and smaller, respectively, than the typical α-gliadins. This variation was caused by insertion or deletion of the unique domain I and a polyglutamine region, possibly the result of illegitimate recombination. Consequently, Gli-cs3 contained 10 cysteine residues, whereas there were 2 cysteine residues only in the other nine sequences. Gli-ta/Gli-ta-like α-gliadin genes are normally expressed during the development of seeds. SDS-PAGE analysis showed that in-vitro-expressed Gli-ta could form intermolecular disulphide bonds and could be chain extenders. A protein band similar in size to Gli-ta has been observed in seed extracts, and mass spectrometry results confirm that the band contains small molecular mass α-gliadins, which is a characteristic of the novel α-gliadins. Mass spectrometry results also indicated that the two cysteine residues of Gli-ta/Gli-ta-like proteins participated in the formation of intermolecular disulphide bonds in vivo.
De novoassembly of thePseudomonas syringaepv.syringaeB728a genome using Illumina/Solexa short sequence reads (2008)

Illumina's Genome Analyzer generates ultra-short sequence reads, typically 36 nucleotides in length, and is primarily intended for resequencing. We tested the potential of this technology for de novo sequence assembly on the 6 Mbp genome of Pseudomonas syringae pv. syringae B728a with several freely available assembly software packages. Using an unpaired data set, velvet assembled >96% of the genome into contigs with an N50 length of 8289 nucleotides and an error rate of 0.33%. edena generated smaller contigs (N50 was 4192 nucleotides) and comparable error rates. ssake and vcakeyielded shorter contigs with very high error rates. Assembly of paired-end sequence data carrying 400 bp inserts produced longer contigs (N50 up to 15 628 nucleotides), but with increased error rates (0.5%). Contig length and error rate were very sensitive to the choice of parameter values. Noncoding RNA genes were poorly resolved in de novo assemblies, while >90% of the protein-coding genes were assembled with 100% accuracy over their full length. This study demonstrates that, in practice, de novo assembly of 36-nucleotide reads can generate reasonably accurate assemblies from about 40 × deep sequence data sets. These draft assemblies are useful for exploring an organism's proteomic potential, at a very economic low cost.
Effects of crest factor reduction on the predistortion performance for multi-carrier 3G RF power amplifiers (2009)

In this paper, an analysis of the crest factor reduction effects' on the predistortion performance of 3G multi-carrier power amplifiers is carried out. This study is performed at three different levels: the power amplifier level, the digital predistorter level, and the system level (linearized amplifier) for a Doherty amplifier driven by 3-carrier WCDMA signal. At the amplifier level, the use of crest factor reduction results in higher power efficiency, increased output power but also distortions. Experimental results show that this compromises the performance of the digital predistorter. The system level analysis highlighted that, in such case, the gained efficiency at the amplifier level will be lost after linearization. This is the first study that points out and experimentally reports the drawbacks of crest factor reduction when applied to digitally predistorted multi-carrier power amplifiers.
Determinants on surface proteins of Plasmodium knowlesi merozoites common to Plasmodium falciparum schizonts. (1980)

In this report and (R. Schmidt-Ullrich, L. H. Miller, and D. F. H. Wallach. Manuscript in preparation.), we have demonstrated that malaria proteins on the surface of merozoites and infected erythrocytes cross-react between at least two primate malarias, Plasmodium knowlesi and P. falciparum. Sera from five Gambian adults who were highly immune to P. falciparum were used as a reagent to study the cross-reactivity between P. falciparum schizonts and surface proteins on P. knowlesi merozoites. Although the sera bound to the surface of viable, intact P. knowlesi merozoites, the sera did not block invasion of rhesus erythrocytes. 125I-lactoperoxidase-labeled surface proteins on merozoites formed complexes with the antibody. All major protein bands seen in the electrophoresis of the original Triton extract were bound by the immune sera. Because Gambians have never been exposed to P. knowlesi malaria, the antibodies that reacted with P. knowlesi merozoites must be directed against antigens of another parasite such as P. falciparum. We tested this hypothesis by competition for antibody in a Gambian serum between Triton-extracted antigens from P. falciparum schizont-infected erythrocytes and from surface-labeled P. knowlesi merozoites. P. falciparum inhibited the reaction, thus indicating cross-reaction between antigens in P. falciparum schizonts and P. knowlesi merozoites.
Migration of Elastic Capsules by an Optical Force in a Uniform flow (2015)

The behavior of an elastic capsule by an optical force in a uniform flow is examined by using the penalty immersed boundary method. The elastic capsule is subjected to the laser beam with Gaussian distribution in the perpendicular direction to the fluid flow. The elastic capsule migrated by the optical force along the direction of the laser beam propagation, and the migration distance is dependent on its properties. The oblate capsule with b/a = 0.5 obeying the neo-Hookean constitutive law is first considered, and the effects of the surface Young's modulus and the initial inclination angle on the migration distance are studied. The migration distance of the oblate capsule is increased as the surface Young's modulus increases, and the non-inclined oblate capsule is more migrated than the differently inclined capsules. Then the spherical, oblate, and biconcave capsules obeying the Skalak constitutive law are considered. A comparison of the trajectories of the capsules indicates that the migration of the spherical capsule is the largest. Unlike the oblate capsule, the non-inclined biconcave capsule is less migrated than other inclination angles due to its initial shape.