gebhart/patrepeval huggingface dataset:
Pilot study of dual imaging with 89Zr-IAB2M and 68Ga-PSMA-11 PET/CT prior to prostatectomy. (2019)

90 Background: Due to high expression of Prostate Specific Membrane Antigen (PSMA), it’s an excellent candidate for targeted molecular imaging. 89 Zr-df-IAB2M is a J591 antibody derived minibody and 68 Ga-PSMA-11 is a PSMA small molecule. Methods: Patients with clinically significant (defined as: ≥ 0.5 cm3 with Gleason pattern ≥ 4) localized prostate cancer (PCa) on conventional imaging modalities who planned to undergo surgery were imaged by PET/CT 1-3 hours after 5±2mCi of 68 Ga-PSMA-11 injection and 89 Zr-IAB2M PET 2-4 days after 10mg IAB2M labeled with 2.5 mCi of 89 Zr injection. Image results were interpreted by a central reader without knowledge of the surgical pathology, mapped and the mapped findings later compared with surgical pathology map. Results: 9 patients having clinically localized PCa with median age 65 (46-79) and PSA 8.42 (1.6-12.2) were enrolled. All dominant PCa lesions, which had a median Gleason score 8 (6-9), were detected by both IAB2M and PSMA-11. The smallest of these dominant lesions was 8mm in size. Median SUVmax for dominant lesions was 3.3 (2.3-7.5) on IAB2M and 7.1 (1.6-23.2) on PSMA-11; median MR PIRADS was 4 (4-5). Of 9 Gleason 6 lesions identified on pathology, PSMA-11 detected 3 and IAB2M detected 2. Four extra-prostatic lesions in one patient were detected by both PET agents, 3 were confirmed by surgical pathology and 1 confirmed on bone scan 2 months post-op. A total of 8 lesions reported on scans were not reported by path: 3 were false positive on both scans, 3 were false positive on IAB2M scan only and 2 were false positive on PSMA-11 scan only. 5 Gleason 6 and 2 Gleason 3+4 lesions on pathology were missed by both PET agents and could be considered false negatives. Conclusions: In this small pilot series, performance of the both PET agents was very similar. An advantage of IAB2M is its hepatobiliary clearance rather than renal/urinary, which makes it potentially easier to visualize the PCa and/or pelvic disease; an advantage of PSMA-11 is the ability to image within 1 hour. Clinical trial information: NCT03675451.
User's manual for EZPLOT version 5.5: A FORTRAN program for 2-dimensional graphic display of data (1988)

EZPLOT is a computer applications program that converts data resident on a file into a plot displayed on the screen of a graphics terminal. This program generates either time history or x-y plots in response to commands entered interactively from a terminal keyboard. Plot parameters consist of a single independent parameter and from one to eight dependent parameters. Various line patterns, symbol shapes, axis scales, text labels, and data modification techniques are available. This user's manual describes EZPLOT as it is implemented on the Ames Research Center, Dryden Research Facility ELXSI computer using DI-3000 graphics software tools.
Near edge x-ray absorption fine structure measurements of surface segregation in 157 nm photoresist blends (2003)

The surface and bulk chemistry of photoresist blends for use at the 157 nm node were analyzed using near edge x-ray absorption fine structure spectroscopy to quantify component segregation and identify surface phenomena that may impact pattern formation. Spectral combinations of the constituent polymers are used to fit the spectra of the blend films. Significant segregation of one component to the surface of the photoresist film was found, in excess of the composition of that component in the blend. The bulk data were consistent with initial blend compositions. As expected, the more hydrophobic or lower surface tension component wets the film surface even under typical photoresist processing conditions.
Realization of a bipolar atomic Solc filter in the cavity-QED microlaser (2010)

We report experimental realization of a rudimentary atomic Šolc filter, recently proposed by Hong et al. [Opt. Express 17, 15455 (2009)]. It is realized by employing a bipolar atom-cavity coupling constant in the cavity-QED microlaser operating with a TEM10 mode in a strong coupling regime. The polarity flip in the coupling constant dramatically changes the photoemission probability of a two-level atom relative to unipolar coupling, resulting in multiple narrow emission bands in the detuning curve of the microlaser mean photon number. The observed resonance curves are explained well by a two-step, three-dimensional, geodesic-like motion of the Bloch vector in the semiclassical limit.
Invited: Multiclass RNA function classification using next-generation sequencing (2011)

RNA-seq produces detailed information including length, strand and pairing states, which can be leveraged to characterize RNA functional categories using machine-learning approaches. Using fruit fly small-RNA-seq data, we demonstrate that by combining read length correlation with multi-class classifier models, we can classify four non-coding RNA function classes with high precision.
Guest-host association by transition-metal complexes containing permanent voids - progress toward models for the ternary complex of cytochrome P450 (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGuest-host association by transition-metal complexes containing permanent voids - progress toward models for the ternary complex of cytochrome P450Kenneth J. Takeuchi, Daryle H. Busch, and Nathanial AlcockCite this: J. Am. Chem. Soc. 1981, 103, 9, 2421–2422Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ja00399a054https://doi.org/10.1021/ja00399a054research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Echo-Guided High-Intensity Focused Ultrasound Ablation on Localized Experimental Tumors (2006)

We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue without injuring the surrounding organs. We therefore established a localized tumor model by inoculating VX2 tumor into rabbit livers. The localized VX2 tumors of nine rabbits were transdermally treated with split-focus ablation at a peak intensity in water of 6 kW/cm2 for 4 s (6 shots) under the guidance of ultrasonic B-mode imaging. Necropsy a day after treatment found the surface of the livers and gastrointestinal tracts to be grossly normal. The VX2 tumors were completely coagulated and were surrounded by ablated liver tissue. The six shots of split-focus HIFU destroyed the VX2 tumors without injuring the liver surfaces or the surrounding organs. These results suggest that split-focus HIFU ablation could be an effective treatment of localized tumors.
ChemInform Abstract: Additive and Medium Effects on Lewis Acid‐Promoted Cationic π‐ Cyclizations of Alkenyl‐ and Alkynylcyclopentane‐1,3‐diones. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process (2012)

The rising costs of bioprocess research and development emphasize the need for high-throughput, low-cost alternatives to bench-scale bioreactors for process development. In particular, there is a need for platforms that can go beyond simple batch growth of the organism of interest to include more advanced monitoring, control, and operation schemes such as fed-batch or continuous. We have developed a 1-mL microbioreactor capable of monitoring and control of dissolved oxygen, pH, and temperature. Optical density can also be measured online for continuous monitoring of cell growth. To test our microbioreactor platform, we used production of a plasmid DNA vaccine vector (pVAX1-GFP) in Escherichia coli via a fed-batch temperature-inducible process as a model system. We demonstrated that our platform can accurately predict growth, glycerol and acetate concentrations, as well as plasmid copy number and quality obtained in a bench-scale bioreactor. The predictive abilities of the micro-scale system were robust over a range of feed rates as long as key process parameters, such as dissolved oxygen, were kept constant across scales. We have highlighted plasmid DNA production as a potential application for our microbioreactor, but the device has broad utility for microbial process development in other industries as well. Keywords: microbioreactors; Escherichia coli; plasmid biopharmaceuticals; bioprocess development
Upgrades from a Previous Device Compared to De Novo Cardiac Resynchronization Therapy in the European Society of Cardiology CRT Survey II (2018)

Despite a lack of evidenced-based data, close to one quarter of all CRT implantations across 42 ESC countries were upgrades from a previous PM or ICD. Despite older age and worse symptoms, the CRT implantation procedures in upgraded patients were equally frequently successful and complications similar to de novo implantations. These results call for more studies.
A Minimal Solution to the Generalized Pose-and-Scale Problem (2014)

We propose a novel solution to the generalized camera pose problem which includes the internal scale of the generalized camera as an unknown parameter. This further generalization of the well-known absolute camera pose problem has applications in multi-frame loop closure. While a well-calibrated camera rig has a fixed and known scale, camera trajectories produced by monocular motion estimation necessarily lack a scale estimate. Thus, when performing loop closure in monocular visual odometry, or registering separate structure-from-motion reconstructions, we must estimate a seven degree-of-freedom similarity transform from corresponding observations. Existing approaches solve this problem, in specialized configurations, by aligning 3D triangulated points or individual camera pose estimates. Our approach handles general configurations of rays and points and directly estimates the full similarity transformation from the 2D-3D correspondences. Four correspondences are needed in the minimal case, which has eight possible solutions. The minimal solver can be used in a hypothesize-and-test architecture for robust transformation estimation. Our solver also produces a least-squares estimate in the overdetermined case. The approach is evaluated experimentally on synthetic and real datasets, and is shown to produce higher accuracy solutions to multi-frame loop closure than existing approaches.
Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions (2005)

The antiatherogenic effects of soy isoflavone consumption have been demonstrated in a variety of studies. However, the mechanisms involved remain poorly defined. Adhesion of monocytes to vascular endothelial cells is a key step within the inflammatory cascade that leads to atherogenesis. Many factors, including the physical forces associated with blood flow, regulate this process. Using an in vitro flow assay, we report that genistein, a principal component of most isoflavone preparations, inhibits monocyte adhesion to cytokine (TNF-alpha)-stimulated human vascular endothelial cells at physiologically relevant concentrations (0-1 microM). This effect is absolutely dependent on flow and is not observed under static conditions. Furthermore, this inhibition was dependent on activation of endothelial peroxisomal proliferator-activated receptor-gamma. No significant role for other reported properties of genistein, including antioxidant effects, inhibition of tyrosine kinases, or activation of estrogen receptors, was observed. Furthermore, the antiadhesive effects of genistein did not occur via modulation of the adhesion molecules E-selectin, ICAM-1, VCAM-1, or platelet-endothelial cell adhesion molecule-1. These data reveal a novel anti-inflammatory mechanism for isoflavones and identify the physical forces associated with blood flow and a critical mediator of this function.
Attosecond Time-Resolved Photoemission from Core and Valence States of Magnesium (2012)

We report on laser-assisted attosecond photoemission from single-crystalline magnesium. In strong contrast to the previously investigated transition metal tungsten, photoelectron wave packets originating from the localized core level and delocalized valence-band states are launched simultaneously from the solid within the experimental uncertainty of 20 as. This phenomenon is shown to be compatible with a heuristic model based on free-particle-like propagation of the electron wave packets generated inside the crystal by the attosecond excitation pulse and their subsequent interaction with the assisting laser field at the metal-vacuum interface.
A Selective, Dual Emission β-Alanine Aminopeptidase Activated Fluorescent Probe for the Detection of Pseudomonas aeruginosa, Burkholderia cepacia, and Serratia marcescens (2019)

Selective detection of β-alanyl aminopeptidase (BAP)-producing <i>Pseudomonas aeruginosa</i>, <i>Serratia marcescens</i>, and <i>Burkholderia cepacia</i> was achieved by employing the blue-to-yellow fluorescent transition of a BAP-specific enzyme substrate, 3-hydroxy-2-(<i>p</i>-dimethylaminophenyl)flavone derivative, incorporating a self-immolative linker to β-alanine. Upon cellular uptake and accumulation of the substrate by viable bacterial colonies, blue fluorescence was generated, while hydrolysis of the <i>N</i>-terminal peptide bond by BAP resulted in the elimination of the self-immolative linker and the restoration of the original fluorescence of the flavone derivative.
Implicit 1D Transport Solvers for a Streamline Simulator for Fractured Reservoirs (2007)

Abstract Naturally fractured reservoirs can be seen as a set of low permeability matrix rock blocks and a high permeability network of fracture channels. This representation is conventionally described by a dual porosity model, which is the one used in the present work. More precisely, the porosities and absolute permeabilities at each point of a reservoir are considered to be those of two interpenetrating continua, the matrix and the fractures one. It is also assumed that the flow occurs in fractures only, i.e., the matrix permeability is equal to zero. Mass transfer between matrix and fractures is modeled by empirically determined transfer functions. Fracture permeabilities can differ in orders of magnitude, which results in very different flow velocities in different parts of the reservoir. This circumstance is advantageous for simulating the reservoir numerically with the streamline method [1,4,6,7,8,9,11,17,18,21]. Indeed, in the streamline method the transport part is solved along a set of onedimensional streamlines, and the corresponding time step used for the update of the solution can be chosen independently for each streamline. Therefore, there is no global time step restriction, which is the case for finite difference simulation. This work is a further development of methods, proposed in [19,16] and [2]. We are concerned with the efficient solution of saturation transport along streamlines. To this end, we propose to use an implicit method. This eliminates the CFL restriction on the time step which is inherent to explicit methods, at the price of possibly introducing more numerical diffusion. The numerical method can be further accelerated with the use of adaptive mesh refinement along streamlines [2]. We show that the proposed technique can be useful when one needs to estimate the flow pattern in the reservoir quickly, e.g., for ranking of geological models.
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling (2018)

Differentiated airway epithelia produce sonic hedgehog (SHH), which is found in the thin layer of liquid covering the airway surface. Although previous studies showed that vertebrate HH signaling requires primary cilia, as airway epithelia mature, the cells lose primary cilia and produce hundreds of motile cilia. Thus, whether airway epithelia have apical receptors for SHH has remained unknown. We discovered that motile cilia on airway epithelial cells have HH signaling proteins, including patched and smoothened. These cilia also have proteins affecting cAMP-dependent signaling, including Gα<sub>i</sub> and adenylyl cyclase 5/6. Apical SHH decreases intracellular levels of cAMP, which reduces ciliary beat frequency and pH in airway surface liquid. These results suggest that apical SHH may mediate noncanonical HH signaling through motile cilia to dampen respiratory defenses at the contact point between the environment and the lung, perhaps counterbalancing processes that stimulate airway defenses.
The Antibody Response in Man Following Infection With Viruses of the pox Group: II. Antibody Response Following Vaccination (1958)

Following primary vaccination no antibody was detected up to the tenth day. After this time neutralizing antibody and antihaemagglutinin were present in the majority of individuals, while, with the technique used, complement-fixing antibody was found in less than half those examined. Neutralizing antibody may be found in the blood more that 20 years after primary vaccination; by this time very few show antihaemagglutinin and then only in low titre. Complement-fixing antibody was not found more than 6 months after primary vaccination. In revaccinated individuals the antibody response tended to be higher than after primary vaccination and, when it occurred, often appeared within a week. This suggests that prompt revaccination of smallpox contacts may offer even greater protection than does primary vaccination. The neutralization test is a better measure of immunological response than are either of the other two tests, for these may give a negative result even though there may be a well-marked rise in neutralizing antibody. The ‘early’ type of reaction to revaccination was associated with an antibody response in only about half the subjects examined. In the remainder, the skin reaction, although identical in appearance, must be regarded as allergic in nature and not accompanied by increase in immunity.
Probing buried organic layers in organic light-emitting diodes under operation by electric-field-induced doubly resonant sum-frequency generation spectroscopy (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation T. Miyamae, N. Takada, T. Tsutsui; Probing buried organic layers in organic light-emitting diodes under operation by electric-field-induced doubly resonant sum-frequency generation spectroscopy. Appl. Phys. Lett. 13 August 2012; 101 (7): 073304. https://doi.org/10.1063/1.4746273 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Combined effects of boundary layer dynamics and atmospheric chemistry on aerosol composition during new particle formation periods (2018)

Abstract. Characterizing aerosol chemical composition in response to meteorological changes and atmospheric chemistry is important to gain insights into new particle formation mechanisms. A BAECC (Biogenic Aerosols – Effects on Clouds and Climate) campaign was conducted during the spring 2014 at the SMEAR II station (Station for Measuring Forest Ecosystem–Aerosol Relations) in Finland. The particles were characterized by a high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS). A PBL (planetary boundary layer) dilution model was developed to assist interpreting the measurement results. Right before nucleation events, the mass concentrations of organic and sulfate aerosol species were both decreased rapidly along with the growth of PBL heights. However, the mass fraction of sulfate aerosol of the total aerosol mass was increased, in contrast to a decrease for the organic mass fraction. Meanwhile, an increase in LVOOA (low-volatility oxygenated organic aerosol) mass fraction of the total organic mass was observed, in distinct comparison to a reduction of SVOOA (semi-volatile OOA) mass fraction. Our results demonstrate that, at the beginning of nucleation events, the observed sulfate aerosol mass was mainly driven by vertical turbulent mixing of sulfate-rich aerosols between the residual layer and the newly formed boundary layer, while the condensation of sulfuric acid (SA) played a minor role in interpreting the measured sulfate mass concentration. For the measured organic aerosols, their temporal profiles were mainly driven by dilution from PBL development, organic aerosol mixing in different boundary layers and/or partitioning of organic vapors, but accurate measurements of organic vapor concentrations and characterization on the spatial aerosol chemical composition are required. In general, the observed aerosol particles by AMS are subjected to joint effects of PBL dilution, atmospheric chemistry and aerosol mixing in different boundary layers. During aerosol growth periods in the nighttime, the mass concentrations of organic aerosols and organic nitrate aerosols were both increased. The increase in SVOOA mass correlated well with the calculated increase in condensed HOMs' (highly oxygenated organic molecules) mass. To our knowledge, our results are the first atmospheric observations showing a connection between increase in SVOOA and condensed HOMs during the nighttime.
High Plasma Concentrations of Human Atrial Natriuretic Polypeptide in Women with Pregnancy-Induced Hypertension (1988)

Unextracted plasma concentrations of human atrial natriuretic polypeptide (hANP) in 32 normotensive term pregnancies and 18 term pregnancies with pregnancy-induced hypertension (PIH) were measured by kit radioimmunoassay. The mean basal plasma hANP concentration was 299 ± 46 (X ± SD) pg/ml in uncomplicated term pregnancies and 378 ± 75 pg/ml in women with PIH (p < 0.001). Furthermore, two subsets of patients with PIH could be identified on the basis of hANP alone and not on clinical parameters. In one subset, seven PIH patients exhibited hANP concentrations within the 95% confidence limits of uncomplicated pregnancy hANP concentrations, while another subset of 11 hypertensive patients demonstrated markedly elevated hANP (436 ± 53 pg/ml). Maternal age, parity, fetal weight, and gestational age did not affect hANP concentrations in normal term pregnancies. These results suggest that: 1) hANP concentrations do not change during normal pregnancy; 2) are significantly elevated in patients with PIH at term; 3) can differentiate between PIH subpopulations; and 4) may serve as a marker and/or regulator of PIH