gebhart/patrepeval huggingface dataset:
High-Performance Thin Film Transistor with Amorphous In2O3–SnO2–ZnO Channel Layer (2012)

We have developed a high-mobility and high-processability oxide semiconductor using amorphous In2O3–SnO2–ZnO (a-ITZO) as the channel material. An a-ITZO thin-film transistor (TFT) was fabricated by a back-channel-etch process. Its field effect mobility was more than 20 cm2 V-1 s-1 and its subthreshold swing was 0.4 V s-1, which makes it a promising candidate for next-generation TFTs.
Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation (2023)

&lt;p&gt;Figure S1. Characterization of cells and CDK4/6 inhibitors; Figure S2. CDK6 phosphorylates serine residues of the regulatory domain of NFAT4 (NFATc3); Figure S3. Analysis of lung tumor immune infiltrates after CDK4/6 inhibition from KrasG12D (Kras), KrasG12DLkb1 (KL) or KrasG12DTrp53fl/fl (KP) mice; Figure S4. T cell proliferation and cytokine/chemokine profiling of KrasG12DTrp53fl/fl GEMM mice; Figure S5. Tumor antigen experienced T cells are more sensitive to CDK4/6 inhibition; Figure S6. Short-term CDK4/6 inhibition alters the cell cycle status of tumor infiltrating T cells; Figure S7. CDK4/6 inhibition induces changes in the expression of activation and suppression marker genes in tumor-infiltrating T cells; Figure S8. Combination treatment of CDK4/6 inhibitor and anti-PD-1 antibody elicits anti-tumor immunity; Figure S9. Combination treatment of CDK4/6 inhibitor and anti-PD-1 antibody on established tumor; Figure S10. Effect of TCR stimulation and CDK4/6 inhibition on phosphorylation of NFkB; Supplementary Table S1; Supplmentary Table S2; Supplementary Table S3: Selected genes reported to be regulated by NFAT&lt;/p&gt;
Development of combined-supramolecular microextraction with ultra-performance liquid chromatography-tandem mass spectrometry procedures for ultra-trace analysis of carbaryl in water, fruits and vegetables (2020)

For the fast and selective preconcentration-separation of carbaryl from environmental samples, a simple and cheap supramolecular solvent microextraction method (Ss-ME) has been applied with ultra-performance liquid chromatography-tandem mass spectrometry. Various analytical parameters that have a noticeable effect on the extraction of carbaryl by supramolecular liquid phase microextraction were optimised by selecting the peak area as the response. The parameters including pH of solution, type and volume of supramolecular formula, matrix effect and the sample volume were optimised. The quantitative recoveries were obtained between pH 2.0 and 4.0 of sample solution phase by using a supramolecular phase consist of heptanol and tetrahydrofuran. The limit of detection and limit of quantification were 0.03 mg L−1 and 0.09 mg L−1 respectively. The relative standard deviation was 7.11 and the preconcentration factor was 15. The microextraction procedure for trace carbaryl was used for various samples such as fruits, vegetables and water samples with the recovery% range between 90% and 102%.
Increased Risk for Bronchitis after Discharge in Non-vaccinated Very Low Birth Weight Infants (2015)

Non-vaccinated male VLBW infants with older siblings are at increased risk for bronchitis during the first year after discharge. Vaccination according to schedule seems to have protective effects, while underlying mechanisms are unknown. The rate of timely vaccination in preterm infants should be increased.
Anti-Gamma Interferon Antibodies Enhance the Immunogenicity of Recombinant Adenovirus Vectors (2011)

Vaccination for eliciting antigen-specific memory CD8(+) T cells may be facilitated by manipulating the pleiotropic effects of gamma interferon (IFN-γ). We assessed strategies for modulating the contribution of IFN-γ during the development of antigen-specific cytotoxic T lymphocyte (CTL) populations. We first showed that recombinant IFN-γ suppressed antigen expression in vitro from a recombinant adenovirus (rAd) vector in a dose-dependent manner and that addition of an anti-IFN-γ antibody (Ab) eliminated this suppression. Consistent with these in vitro findings, we found that HIV-1 envelope (Env)-specific CTL responses were higher in IFN-γ-knockout (GKO) mice than in wild-type mice following immunization with rAd. Since these observations suggested that IFN-γ might suppress rAd-induced CTL development, we assessed the ability of anti-IFN-γ Ab administration to augment rAd-elicited CTL in vivo. In fact, blockage of IFN-γ activity by monoclonal Ab administration was associated with elevated levels of interleukin 7 receptor alpha chain-positive (IL-7Rα(+)) Env-specific CTL populations postboost. These observations illustrate the utility of an anti-IFN-γ Ab for potentiating rAd immunizations to effect quantitative and qualitative changes in the effector and memory CTL populations.
Activation of a Nuclear Cdc2-Related Kinase within a Mitogen-Activated Protein Kinase-Like TDY Motif by Autophosphorylation and Cyclin-Dependent Protein Kinase-Activating Kinase (2005)

Male germ cell-associated kinase (MAK) and intestinal cell kinase (ICK) are nuclear Cdc2-related kinases with nearly identical N-terminal catalytic domains and more divergent C-terminal noncatalytic domains. The catalytic domain is also related to mitogen-activated protein kinases (MAPKs) and contains a corresponding TDY motif. Nuclear localization of ICK requires subdomain XI and interactions of the conserved Arg-272, but not kinase activity or, surprisingly, any of the noncatalytic domain. Further, nuclear localization of ICK is required for its activation. ICK is activated by dual phosphorylation of the TDY motif. Phosphorylation of Tyr-159 in the TDY motif requires ICK autokinase activity but confers only basal kinase activity. Full activation requires additional phosphorylation of Thr-157 in the TDY motif. Coexpression of ICK with constitutively active MEK1 or MEK5 fails to increase ICK phosphorylation or activity, suggesting that MEKs are not involved. ICK and MAK are related to Ime2p in budding yeast, and cyclin-dependent protein kinase-activating kinase Cak1p has been placed genetically upstream of Ime2p. Recombinant Cak1p phosphorylates Thr-157 in the TDY motif of recombinant ICK and activates its activity in vitro. Coexpression of ICK with wild-type CAK1 but not kinase-inactive CAK1 in cells also increases ICK phosphorylation and activity. Our studies establish ICK as the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs.
Expression of nm23 Protein in Human Osteosarcoma in Relationship With Early Metastasis (2000)

Nm23 protein expression was analyzed by immunohistochemical staining using formalin-fixed, paraffin-embedded sections from 39 cases with osteosarcomas and compared with the histologic findings and early metastasis for the purpose of detecting nm23 expression in osteosarcoma and elucidating the clinical significance of its expression. Immunoreactivity of nm23 protein was detected in 48.7% of the total cases. There was no statistical difference between nm23 expression and early metastasis, but there was a trend for cases with nm23 expression to progress to early metastasis within 1 year after operation. The role of nm23 as a tumor metastasis suppressor in osteosarcomas appeared less prominent.
Immunologic enhancement of rat renal allografts. III. Immunopathologic lesions and rejection in long-surviving passively enhanced grafts. (1975)

Immunologic enhancement of renal allografts from (Lewis times Brown Norway) F1 to Lewis rats was achieved by administering a single dose of antidonor serum at the time of transplantation. A series of grafts functioning for 1 to 4 months after transplantation were examined by light and immunofluorescence microscopy to evaluate the long-term protective effects of the enhancing serum and to determine if previously unobserved lesions appeared in long survivors. Despite the absence of detectable circulating cytotoxic alloantibody, long-term allografts showed necrotizing glomerular and arterial lesions which resembled those seen in acutely rejecting grafts and were compatible with humoral rejection. Thus, in this model, there is a late decline in the ability of passive enhancement to inhibit humoral rejection. Long-term grafts also developed tubular lesions with deposition of immunoglobulin and complement on the tubular basement membranes (TBM). Anti-TBM antibodies were demonstrated in recipients' sera and found to be organ specific but not major histocompatibility antigen or species specific. This tubular lesion is therefore a unique form of allograft injury in which the immune response is directed against tissue antigen(s) which are distinct from the major histocompatibility antigens that induce rejection.
Intensity fluctuation spectroscopy of small numbers of dye molecules in a microcavity (1998)

The spontaneous emission from a thin layer of a dilute solution of fluorescent dye molecules within an optical microcavity has been studied. Strong fluctuations in fluorescence intensity are observed when the average number of molecules in the measurement volume is small. We have performed experiments that simultaneously characterize these fluctuations over nine orders of magnitude of time, from ns to s. These measurements have identified photon antibunching characteristic of single-molecule emission, along with triplet-state shelving and diffusion driven number fluctuations. The results give fundamental information on the kinetics of dye molecules and allow one to speculate about the prospect of using single molecules as sources of single photons for quantum optics.
ChemInform Abstract: Photocatalytic Property and Electronic Structure of Lanthanide Tantalates, LnTaO4 (Ln: La, Ce, Pr, Nd, and Sm). (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gas-phase NMR studies of N,N-dimethylamides. Inter- and intramolecular contributions to internal rotation activation energies (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase NMR studies of N,N-dimethylamides. Inter- and intramolecular contributions to internal rotation activation energiesBrian D. Ross, Leland T. Wong, and Nancy S. TrueCite this: J. Phys. Chem. 1985, 89, 5, 836–839Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://pubs.acs.org/doi/10.1021/j100251a024https://doi.org/10.1021/j100251a024research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Utility ofScottish morbidity andmortality datafor epidemiological studies ofmotor neuron disease (1993)

Objectives-To determine theaccuracy of(1) hospital discharge dataand(2)deathcertificates, codedas motor neurondisease (MND). Design-Comparison of datafrom The Scottish MotorNeuronDiseaseRegister (SMNDR)withroutinely collected Scottish Hospital In-Patient Statistics (SHIPS)and deathcertificate coding. Setting-Scotland UK. Patients-1) 379adults(>15years)dischargedforthefirst timefroma Scottish hospital in1989-90 and(2)281deathsinthe sameperiodassigned totheInternational Classification ofDiseases (ICD)-9, category 335(MND). Main outcomemeasures-Thesensitivity andpositive predictive valueofadiagnosis of MND asretrieved by(1)theInformation and Statistics Division oftheCommon Services AgencyfortheScottish HealthService for morbidity dataand(2)theRegistrar General's office formortality data,usingthe SMNDR asthe'gold standard'. Results-(l) Thirty percentofadultpatients identified ashaving MND bySHIPSdidnot havethisdisease and23%ofpatients with MND didnotappearon SHIPS.Thesensitivity ofadiagnosis ofMND,asretrieved by SHIPS,was84%andthepositive predictive valuewas70%overall. Miscoding ofpatients with pseudobulbar palsycausedby cerebrovascular diseasewas the major sourceoffalse positive error.Theincidence ofadult onsetsporadic MND was overestimatedby SHIPSbya factorof1-6.(2) Mortality datawere more accurate, witha false negative rateof6%andapositive predictive valueof90%. Conclusions-Coded
Extension to the Silyl-Tethered Radical Cyclization: Cyclohex-2-en-1-oxy Vinyl Silanes in Stereoselective Radical Addition/Cyclization Cascades (2017)

A novel radical cascade reaction of xanthates with 1-[(vinyldimethylsilyl)oxy]cyclohex-2-enes is developed. Due to the steric and electronic differentiation of the two olefinic functions, exclusive regioselectivity and high stereoselectivity of the addition-cyclization are observed. Several methods for modification of both the silicon tether and the xanthate function are reported.
Microstereolithography production of integrated Hadamard mask structures (2006)

The use of modern microstreolithography (MSL) technology gives optics developers the freedom to integrate mounting and positioning structures directly into an optical mask structure. We have created Hadamard spectrometer masks with increments of 150 &#956;m and less using the Sony SCS-6000 microstereolithography apparatus (MSLA). Due to laser over cure and other parameters, adjustments were made iteration by iteration until appropriate mask tolerances were met. A mounting structure was integrated with the mask for testing and application. At the computer aided design (CAD) model level, the mounting geometry can be adjusted to fit any specific mounting apparatus. By using the MSLA, features as small as 75 &#956;m and larger than 300 mm can be created in the same build. Additionally, the conceptual design of an entire positioning system constructed using layer additive MSLA microfabrication is underway. This positioning system may be built as an integrated assembly, encapsulating necessary components. Optical characterization results are presented.
Comparative Pull-Out Strength of Tapped and Untapped Pilot Holes for Bicortical Anterior Cervical Screws (1997)

Tapping a pilot hole for bicortical screws of the anterior cervical spine neither weakens nor strengthens the axial pull-out strength of fully threaded cortical bone screws. Tapping may be unnecessary; however, it may be desirable in patients with dense bone to cut the thread profile into the bone or if the screws have dull tips and threads.
768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice (2021)

<h3>Background</h3> Tumor-localized delivery of Toll-like receptor (TLR) agonists is a promising strategy to promote immune activation within the tumor microenvironment (TME) to overcome tumor immunosuppression and induce anti-tumor immune responses. To enable localization to multiple tumor sites following systemic administration, we developed a fully-synthetic tumor-targeting TLR9 agonist and demonstrate its potential to transform the tumor immune microenvironment for effective tumor regression in mice. <h3>Methods</h3> An engineered synthetic peptide (PIP) that binds to multiple integrin receptors overexpressed in many solid tumors was chemically conjugated to a synthetic CpG oligonucleotide (TLR9 agonist), thereby generating a tumor-targeting immune-stimulant referred to as PIP-CpG. To facilitate clinical translation, PIP-CpG is cross-reactive between mouse, non-human primate, and human. Therapeutic studies were conducted in immune-competent mice bearing breast or pancreatic tumors to evaluate the efficacy of intravenously (IV)-injected PIP-CpG compared to IV-injected unmodified CpG or vehicle (PBS). We then performed mechanistic studies to evaluate the immune response elicited by PIP-CpG therapy. <h3>Results</h3> Intravenous dosing of PIP-CpG led to tumor regression and prolonged survival, and in some cases cures, relative to vehicle or unmodified CpG therapy in both murine breast (4T1) and pancreatic cancer (KPC-G2) models. This tumor regression was dependent on T cells as T cell depletion resulted in loss of therapeutic response. To study the effect of systemic therapy on the cellular landscape in the TME, we analyzed 4T1 breast tumors by flow cytometry. We found that vehicle and CpG IV-dosed mice had immunosuppressive TMEs comprised mostly of myeloid-derived suppressor cells (MDSCs; 43–68% of live cells) with minimal infiltrating T cells and B cells (5–16% of live cells). In contrast, the TME of PIP-CpG treated mice was transformed into a lymphocyte-rich “hot” tumor phenotype with massive infiltration by T cells and B cells (92–95% of live cells) and plummeting levels of MDSCs (down to ~1%). In addition, tumor-specific effector CD8+ T cells were generated in response to PIP-CpG therapy, but not CpG dosed IV, indicating that PIP-CpG therapy transforms the TME and elicits a T cell-mediated tumor-specific immune response. Furthermore, PIP-CpG was effective for treating MMTV-PyMT transgenic mice, which spontaneously develop multiple breast tumors. Murine toxicity studies indicated that effects of PIP-CpG were similar to CpG dosed IV or intratumorally, which have been well-tolerated in human clinical trials. <h3>Conclusions</h3> Tumor-directed systemic delivery of a TLR9 agonist transforms the TME via activated B and T cells and is promising for further development in patients with solid tumors. <h3>Ethics Approval</h3> All mouse experiments were performed in accordance with protocols approved by the Stanford Administrative Panel on Laboratory Animal Care.
UsingModel-Driven Bundle-Adjustment to Model Heads from Raw Video Sequences (1999)

We show that we can effectively and automatically fit a complex facial animation model to uncalibrated image sequences. Our approach is based on model-driven bundleadjustment followed by least-squares fitting. It takes advantage of three complementary sources of information: stereo data, silhouette edges and 2--D feature points. In this way, complete head models can be acquired with a cheap and entirely passive sensor, such as an ordinary video camera. They can then be fed to existing animation software to produce synthetic sequences. 1 Introduction In earlier work [8], we have proposed an approach to fitting complex head animation models, including ears and hair, to registered stereo pairs and triplets. Here, we extend this approach so that it can take advantage of image sequences taken with a single camera, without requiring calibration data. We treat consecutive image pairs in the sequences as stereo pairs and compute disparity maps. Thus, the key issue is the estimation of the ...
Diversity Properties of Multiantenna Small Handheld Terminals (2004)

Experimental data are presented on the viability of multiple antennas on small mobile handsets, based on extensive measurement campaigns at 2.14 GHz with multiple base stations, indoors, from outdoor to indoor, and outdoors. The results show medium to low correlation values between antenna branch signals despite small antenna separations down to . Amplitude distributions are mainly Rayleigh-like, but for early and late components steeper than Rayleigh. Test users handling the measurement handset caused larger delay spread, increased the variability of the channel, and induced rather large mean branch power differences of up to 10 dB. Positioning of multiple antennas on small terminals should therefore be done with care. The indoor channels were essentially flat fading within 7 MHz bandwidth ( ); the outdoor-to-indoor and outdoor channels, measured with 10 MHz bandwidth, were not. For outdoor-to-indoor and outdoor channels, we found that different taps in the same impulse response are uncorrelated.
Identification of Amino Acids in Marburg Virus VP40 That Are Important for Virus-Like Particle Budding (2011)

The matrix protein VP40 of Marburg virus promotes the formation and release of virus-like particles (VLPs). Marburg virus VP40 interacts with cellular Tsg101 via its L domain motif; however, mutation of this motif does not affect VLP budding or the accumulation of VP40 in multivesicular bodies (MVBs), which are platforms for virus particle formation. To identify regions of Marburg virus VP40 that are important for VLP budding, we examined deletion mutants and alanine-scanning mutants at the N- and C-terminus of VP40 for their involvement in VLP budding. VLPs were not detected in the presence of alanine-replacement mutants at Ile39 and Thr40, and the level of VLP budding for the alanine mutant at Asn297 was decreased. Moreover, these mutants did not accumulate in MVBs. Our results suggest the involvement of a novel host factor(s) in VLP budding and VP40 transport to MVBs.
Supplementary Figure 4 from Targeting HER-2/<i>neu</i> in Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion (2023)

Supplementary Figure 4 from Targeting HER-2/&lt;i&gt;neu&lt;/i&gt; in Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion
In vitro sulfotransferase activity of NodH, a nodulation protein of Rhizobium meliloti required for host-specific nodulation (1995)

Early stages of nodulation involve the exchange of signals between the bacterium and the host plant. Bacterial nodulation (nod) genes are required for Rhizobium spp. to synthesize lipooligosaccharide morphogens, termed Nod factors. The common nod genes encode enzymes that synthesize the factor core structure, which is modified by host-specific gene products. Here we show direct in vitro evidence that Rhizobium meliloti NodH, a host-specific nodulation gene, catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to the terminal 6-O position of Nod factors, and we show substrate requirements for the reaction. Our results indicate that polymerization of the chitooligosaccharide backbone likely precedes sulfation and that sulfation is not absolutely dependent on the presence or the particular structure of the N-acyl modification. NodH sulfation provides a tool for the enzymatic in vitro synthesis of novel Nod factors, or putative Nod factors intermediates, with high specific activity.