gebhart/patrepeval huggingface dataset:
Multiple Myeloma in the Very Old: An IASIA Conference Report (2014)

Multiple myeloma (MM) in patients aged greater than 80 years poses an increasingly common challenge for oncology providers. A multidisciplinary workshop was held in which MM-focused hematologists/oncologists, geriatricians, and associated health-care team members discussed the state of research for MM therapy, as well as themes from geriatric medicine that pertain directly to this patient population. A summary statement of our discussions is presented here, in which we highlight several topics. MM disproportionately affects senior adults, and demographic trends indicate that this trend will accelerate. Complex issues impact cancer in seniors, and although factors such as social environment, comorbidities, and frailty have been well characterized in nononcological geriatric medicine, these themes have been inadequately explored in cancers such as MM, despite their clear relevance to this field. Therapeutically, novel agents have improved survival for MM patients of all ages, but less so for seniors than younger patients for a variety of reasons. Lastly, both MM- and treatment-related symptoms and toxicities require special attention in senior adults. Existing research provides limited insight into how best to manage these often complex patients, who are often not reflected in typical clinical trial populations. We hence offer suggestions for clinical trials that address knowledge gaps in how to manage very old and/or frail patients with MM, given the complicated issues that often surround this patient population.
Field Attractants for Pachnoda interrupta Selected by Means of GC-EAD and Single Sensillum Screening (2009)

The sorghum chafer, Pachnoda interrupta Olivier (Coleoptera: Scarabaeidae: Cetoniinae), is a key pest on sorghum, Sorghum bicolor (L.) Moench (Poaceae), in Ethiopia. At present there is a lack of efficient control methods. Trapping shows promise for reduction of the pest population, but would benefit from the development of attractive lures. To find attractants that could be used for control of P. interrupta, either by mass trapping or by monitoring as part of integrated pest management, we screened headspace collections of sorghum and the highly attractive weed Abutilon figarianum Webb (Malvaceae) for antennal activity using gas chromatograph-coupled electroantennographic detection (GC-EAD). Compounds active in GC-EAD were identified by combined gas chromatography and mass spectrometry (GC-MS). Field trapping suggested that attraction is governed by a few influential compounds, rather than specific odor blends. Synthetic sorghum and abutilon odor blends were attractive, but neither blend outperformed the previously tested attractants eugenol and methyl salicylate, of which the latter also was part of the abutilon blend. The strong influence of single compounds led us to search for novel attractive compounds, and to investigate the role of individual olfactory receptor neurons (ORNs) in the perception of kairomones. We screened the response characteristics of ORNs to 82 putative kairomones in single sensillum recordings (SSR), and found a number of key ligand candidates for specific classes of ORNs. Out of these key ligand candidates, six previously untested compounds were selected for field trapping trials: anethole, benzaldehyde, racemic 2,3-butanediol, isoamyl alcohol, methyl benzoate and methyl octanoate. The compounds were selected on the basis that they activated different classes of ORNs, thus allowing us to test potential kairomones that activate large non-overlapping populations of the peripheral olfactory system, while avoiding redundant multiple activations of the same ORN type. Field trapping results revealed that racemic 2,3-butanediol is a powerful novel attractant for P. interrupta.
Effect of Composition on Electrical and Optical Properties of Thin Films of Amorphous Ga x Se100−x Nanorods (2010)

We report the electrical and optical studies of thin films of a-Ga(x)Se(100-x) nanorods (x = 3, 6, 9 and 12). Thin films of a-Ga(x)Se(100-x) nanorods have been synthesized thermal evaporation technique. DC electrical conductivity of deposited thin films of a-Ga(x)Se(100-x) nanorods is measured as a function of temperature range from 298 to 383 K. An exponential increase in the dc conductivity is observed with the increase in temperature, suggesting thereby a semiconducting behavior. The estimated value of activation energy decreases on incorporation of dopant (Ga) content in the Se system. The calculated value of pre-exponential factor (sigma(0)) is of the order of 10(1) Omega(-1 )cm(-1), which suggests that the conduction takes place in the band tails of localized states. It is suggested that the conduction is due to thermally assisted tunneling of the carriers in the localized states near the band edges. On the basis of the optical absorption measurements, an indirect optical band gap is observed in this system, and the value of optical band gap decreases on increasing Ga concentration.
Acoustic filter design for precise measurement of parametric array in near-field region (2012)

A parametric array is a nonlinear conversion process that generates a narrow beam of low-frequency sound using a small aperture and that is used in active underwater SONAR and communication systems. A parametric array generates a highly directional difference frequency wave (DFW) by nonlinear interaction of bi-frequency primary waves at higher frequencies. However, it is difficult to measure the parametric array effect in the near distance of the transducer, because the high-pressure level of the primary waves may cause the receiving transducer to provide with pseudo-sound signals of difference frequency by its nonlinearity. The pseudo-sound signals make it difficult to measure the real DFW due to the parametric array process. In this study, we confirmed the existence of pseudo-sound and its effects on measurement of the near-distance DFW by the parametric array using numerical simulations based on the KZK equation. Also, a newly designed acoustic filter was proposed to eliminate pseudo-sound signals. This new acoustic filter uses the resonance of a thickness extensional mode. With the acoustic filter, low frequencies (DFW) were passed and high frequencies (primary frequencies) were effectively reduced. Using this acoustic filter, the precise characteristics of the difference frequencies could be measured. [Work supported by ADD(UD100002KD).]
Twitter Footprint and the Match in the COVID-19 Era: Understanding the Relationship between Applicant Online Activity and Residency Match Success (2022)

Our study of the 2021 urology residency application cycle and use of Twitter highlighted distinct differences among matched and unmatched applicants and their respective Twitter analytics, highlighting a potential professional development opportunity offered by social media in underscoring applicants' profiles.
Ultra-Fine Spherical Particles of γ-Alumina: Electron Microscopy of Crystal Structure and Surface Morphology at Atomic Resolution (1984)

The γ-alumina particles are produced by a dry method developed by the author. Three types of structures, tentatively called δ' (orthorhombic; Pmn2 1 ; a =8.2, b =16.4, c =11.8 Å), θ 1 (monoclinic; B2/b; a =11.1, b =12.1, c =17.7 Å, β=103° ) and θ 2 (monoclinic, B2/m; a =11.1, b =12.1, c =2.9 Å, β=103°) are found. The particle is spherical but facetted with flat {111} and {100} surfaces; {110} surfaces consist of many small {111} facets. As a new approach to ceramics and catalysis research, surface morphology of a neck portion of two coalescing particles, and clusters of Rh 6 (CO) 16 impregnated on the particles are demonstrated for the first time.
Combining density functional theory with macroscopic QED for quantum light-matter interactions in 2D materials (2021)

A quantitative and predictive theory of quantum light-matter interactions in ultra thin materials involves several fundamental challenges. Any realistic model must simultaneously account for the ultra-confined plasmonic modes and their quantization in the presence of losses, while describing the electronic states from first principles. Herein we develop such a framework by combining density functional theory (DFT) with macroscopic quantum electrodynamics, which we use to show Purcell enhancements reaching 10<sup>7</sup> for intersubband transitions in few-layer transition metal dichalcogenides sandwiched between graphene and a perfect conductor. The general validity of our methodology allows us to put several common approximation paradigms to quantitative test, namely the dipole-approximation, the use of 1D quantum well model wave functions, and the Fermi's Golden rule. The analysis shows that the choice of wave functions is of particular importance. Our work lays the foundation for practical ab initio-based quantum treatments of light-matter interactions in realistic nanostructured materials.
Pathological Upgrading and Up Staging With Immediate Repeat Biopsy in Patients Eligible for Active Surveillance (2008)

Immediate repeat biopsy in cases of active surveillance with selective delayed intervention resulted in 27% being upgraded or up staged and those were more likely to show higher grade and stage disease at radical prostatectomy. We recommend repeat biopsy because it improved our discrimination of who are the best candidates for active surveillance with selective delayed intervention.
Tradeoff between threshold voltage and breakdown in high-voltage double-diffused MOS transistors (1978)

The design of junction isolated DMOS transistors suitable for monolithic integration has been studied. The purpose of this correspondence is to describe one of the key tradeoffs when designing these devices for high breakdown voltages (200 V for our example). It is a tradeoff primarily between threshold voltage and the punchthrough voltage of the channel diffusion, however, the avalanche breakdown voltage, on-resistance, and source-to-substrate punchthrough voltage are also affected. As an example, the design of a device for 200-V operation is described. The discussion is, however, general and can be applied to other DMOS designs as well.
Marangoni-driven spreading of miscible liquids in the binary pendant drop geometry (2019)

When two liquids with different surface tensions come into contact, the liquid with lower surface tension spreads over the other liquid. This Marangoni-driven spreading has been studied for various geometries and surfactants, but the dynamics of miscible liquids in the binary geometry (drop-drop) has hardly been investigated. Here we use stroboscopic illumination by nanosecond laser pulses to temporally resolve the distance L(t) over which a low-surface-tension drop spreads over a miscible high-surface-tension drop. L(t) is measured as a function of time, t, for various surface tension differences between the liquids and for various viscosities, revealing a power-law L(t) ∼ tα with a spreading exponent α ≈ 0.75. This value is consistent with previous results for viscosity-limited spreading over a deep bath. The universal power law L[combining tilde] ∝ t[combining tilde]3/4 that describes the dimensionless distance L[combining tilde] as a function of the dimensionless time t[combining tilde] reasonably captures our experiments, as well as previous experiments for different geometries, miscibilities, and surface tension modifiers (solvents and surfactants). The range of this power law remarkably covers ten orders of magnitude in dimensionless time. This result enables engineering of drop encapsulation for various liquid-liquid systems.
Fluorenone core donor–acceptor–donor π-conjugated molecules end-capped with dendritic oligo(thiophene)s: synthesis, liquid crystalline behaviour, and photovoltaic applications (2011)

We have synthesized a new series of donor–acceptor–donor (D–A–D) π-conjugated molecules, consisting of fluorenone core end-capped with dendritic oligo(thiophene)s of increasing generation (abbreviated as FG0, FG1, and FG2). In view of the application of these new organic semiconductors in photovoltaic devices, we have explored their spectroscopic, redox, and structural properties. The thermal behaviour of the new organic semiconductors was investigated by differential scanning calorimetry and polarized-light optical microscopy. Liquid crystalline behaviour has been found in the case of FG1, corresponding to a smectic ordering with a triclinic symmetry (Smobl) upon heating, as confirmed by variable temperature small-angle X-ray diffraction studies. In order to evaluate their photovoltaic performances, devices with an active area of 0.28 cm2 were fabricated. Under AM1.5 simulated sunlight (100 mW cm−2) conditions, a device containing FG1/[70]PCBM blends showed a power conversion efficiency of ca. 0.8%.
Low-Dissipation Multiplexed Flux-Sensitive Readout in Superconducting Circuits (2015)

D-Wave's quantum processors require a high-fidelity readout architecture for fast and accurate operation. The need for cold operation precludes readout methods with significant dissipation. The readout architecture must be scalable and compatible with an inherently dense qubit circuit layout. Superconducting microresonators have been successfully utilized as detection elements for a wide variety of applications, enabling superior multiplexing factors. In existing designs, resonators undergo a non-uniform shift in frequency and sensitivity with fabrication imperfections, ultimately limiting effective bandwidth utilization. We overcome this drawback by implementing independent control of both frequency and sensitivity. We describe the design of the detector and report experimental results demonstrating its resilience to fabrication tolerances.
Possible enhancement of vincristine neuropathy by VP-16 (1982)

Eleven consecutive patients with small cell carcinoma of the lung treated intensively with a combination chemotherapy regimen cyclophosphamide, Adriamycin, VP-16, and vincristine experienced peripheral neuropathy. Four of the 11 patients had severe (Grade III) neuropathy, leaving them virtually bedridden; the remaining seven patients had mild to moderate neuropathy. Only 8 of the 14 patients treated less intensively with vincristine and VP-16 had Grade I and II neuropathy. Predisposing factors for severe neuropathy included advanced age and preexisting peripheral neuropathy. All patients' performance status declined and all lost much weight before developing neuropathy. From accumulated treatment experience of small cell carcinoma with vincristine alone or with vincristine, Adriamycin, cyclophosphamide combinations, the authors feel that the severe neuropathy observed was due to an interaction of vincristine and VP-16. This conclusion is supported by electron microscopic observation of electronopaque granular degeneration of the myelin lamellae of affected nerve fibers.
5 GHZ wireless channel characterization for vehicle to vehicle communications (2005)

We provide channel modeling results based upon measurements of the vehicle-to-vehicle (VTV) mobile channel, taken in the 5 GHz frequency band. Our measurements pertain to three types of areas: large cities, open highway areas, and small cities. A spread-spectrum stepped correlator technique was used, with omnidirectional antennas either atop or inside the vehicles. We provide measured and analytical results in the form of power delay profiles and frequency correlation function estimates. Delay spread statistics for these environments, as well as approximate amplitude fading distributions are also provided. The largest values of root-mean-square delay spreads, on the order of 1 microsecond, were obtained in urban areas with dense vehicle traffic, corresponding to coherence bandwidths of as low as 1-2 MHz. Fading amplitude statistics are best fit with a Nakagami-m distribution. Fading channel statistics for an example 10 MHz channel bandwidth are also provided.
Semantically meaningful attributes from co-listen embeddings for playlist exploration and expansion (2020)

Audio embeddings of musical similarity are often used for music recommendations and autoplay discovery. These embeddings are typically learned using co-listen data to train a deep neural network, to provide consistent tripletloss distances. Instead of directly using these co-listen–based embeddings, we explore making recommendations based on a second, smaller embedding space of human-intelligible musical attributes. To do this, we use the co-listen–based audio embeddings as inputs to small attribute classifiers, trained on a small hand-labeled dataset. These classifiers map from the original embedding space to a new interpretable attribute coordinate system that provides a more useful distance measure for downstream applications. The attributes and attribute embeddings allow us to provide a search interface and more intelligible recommendations for music curators. We examine the relative performance of these two embedding spaces (the co-listen–audio embedding and the attribute embedding) for the mathematical separation of thematic playlists. We also report on the usefulness of recommendations from the attribute-embedding space to human curators for automatically extending thematic playlists.
Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation (2020)

Abnormal vasculature in tumors leads to poor tissue perfusion and cytostatic drug delivery. Although drugs inducing vascular normalization, for example, angiopoietin-2 (Ang2)-blocking antibodies, have shown promising results in preclinical tumor models, clinical studies have so far shown only little efficacy. Because Ang2 is known to play a protective role in stressed endothelial cells, we tested here whether Ang2 blocking could enhance radiation-induced tumor vascular damage. Tumor-bearing mice were treated with anti-Ang2 antibodies every 3 or 4 days starting 3 days before 3 × 2 Gy or 4 × 0.5 Gy whole-body or tumor-focused radiation. Combination treatment with anti-Ang2 and radiation improved tumor growth inhibition and extended the survival of mice with melanoma or colorectal tumors. Single-cell RNA-sequencing revealed that Ang2 blocking rescued radiation-induced decreases in T cells and cells of the monocyte/macrophage lineage. In addition, anti-Ang2 enhanced radiation-induced apoptosis in cultured endothelial cells. <i>In vivo</i>, combination treatment decreased tumor vasculature and increased tumor necrosis in comparison with tumors treated with monotherapies. These results suggest that a combination of Ang2-blocking antibodies with radiation increases tumor growth inhibition and extends the survival of tumor-bearing mice. SIGNIFICANCE: These findings offer a preclinical rationale for further testing of the use of radiation in combination with Ang2-blocking antibodies to improve the overall outcome of cancer treatment.
In-situ fiber temperature sensor for anti-Stokes cooling measurements in doped fibers (2018)

The experimental study of cooling by anti-Stokes fluorescence in a fiber or a radiation-balanced fiber laser necessitates the development of a sensor that can measure the temperature of the fiber core with an excellent temperature and spatial resolution, a large dynamic range, a small drift, a fast response, and a low absorptive loss. We report an in-situ slow-light fiber sensor written directly in a Yb-doped silica fiber using a femtosecond laser. The sensor has a spatial resolution of 6.5 mm, an excellent measured temperature resolution of 0.9 m&deg;C/&radic;Hz, and a measured drift as low as 20 m&deg;C/min. One of the grating’s slow-light resonances is interrogated with a tunable 1.55-&mu;m laser to measure the temperature-induced shift in the resonance wavelength when the fiber is optically pumped. The laser frequency is also modulated at 30 kHz to greatly reduce the detection noise. The sensor was pumped with 0.58 mW from a 1020-nm laser and measured a positive temperature change of 0.33 &deg;C. The dominant source of heating is shown to be likely the photodarkening loss induced in the Yb-doped fiber when the FBG was written. The total FBG loss is predicted to be ~24 m<sup>-1</sup> at 1020 nm and expected to reduce after annealing. Projections indicate that if the loss of the rare-earth doped FBG can be decreased to the level of the loss observed in slow-light FBGs written in SMF-28 fibers, these sensors can be used to measure ASF cooling.
Interstitial Ciliates: Benthic Microaerophiles or Planktonic Anaerobes? (2003)

We observed marine benthic interstitial ciliates Geleia sp. and Tracheloraphis sp. inhabiting the water column of a chemically stratified salt pond. This habitat is uncharacteristic for interstitial ciliates, yet they displayed active and abundant planktonic populations (up to 800 and 250 cells/liter, respectively) and a well-defined pattern of vertical distribution. Completely absent from the oxygenated epilimnion, they first appeared at the oxic/anoxic interface and were present throughout the anoxic hypolimnion. The data could not be explained by a passive removal (e.g. by currents) of these ciliates from their conventional habitat (soft sediments) to water column. The results suggest that 1) these ciliates favored an anoxic environment, and 2) they switched to a planktonic lifestyle as appropriate conditions (seasonal anoxia) developed in the water column. This sharply contrasts the classic view of these ciliates as specifically benthic and aerobic (albeit microaerophilic) organisms. We hypothesize that Geleia sp. and Tracheloraphis sp. can readily grow in either water column or benthos, but are typically found in sediments simply because they contain their preferred (anoxic) niche.
Genetic Variation in BEACON Influences Quantitative Variation in Metabolic Syndrome–Related Phenotypes (2004)

The BEACON gene (also known as UBL5) was identified as differentially expressed between lean and obese Psammomys obesus, a polygenic animal model of obesity, type 2 diabetes, and dyslipidemia. The human homologue of BEACON is located on chromosome 19p, a region likely to contain genes affecting metabolic syndrome-related quantitative traits as established by linkage studies. To assess whether the human BEACON gene may be involved in influencing these traits, we exhaustively analyzed the complete gene for genetic variation in 40 unrelated individuals and identified four variants (three novel). The two more common variants were tested for association with a number of quantitative metabolic syndrome-related traits in two large cohorts of unrelated individuals. Significant associations were found between these variants and fat mass (P = 0.026), percentage of fat (P = 0.001), and waist-to-hip ratio (P = 0.031). The same variants were also associated with total cholesterol (P = 0.024), LDL cholesterol (P = 0.019), triglycerides (P = 0.006), and postglucose load insulin levels (P = 0.018). Multivariate analysis of these correlated phenotypes also yielded a highly significant association (P = 0.0004), suggesting that BEACON may influence phenotypic variation in metabolic syndrome-related traits.
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models (2009)

The compounds investigated in this study represent a novel class of MMP-13 inhibitors. They are mechanistically distinct from previously reported broad-spectrum MMP inhibitors and do not exhibit the problems previously associated with these inhibitors, including selectivity, poor pharmacokinetics, and MSS liability. MMP-13 inhibitors exert chondroprotective effects and can potentially modulate joint pain, and are, therefore, uniquely suited as potential disease-modifying osteoarthritis drugs.
Quantitative evaluation of 4D Cone beam CT scans with reduced scan time in lung cancer patients (2019)

A 4D-CBCT acquisition time of 2 min produces scans of sufficient image quality for IGRT in most lung cancer patients, as demonstrated quantitatively by assessing the impact on automatic registration accuracy in simulated and real acquisitions.