gebhart/patrepeval huggingface dataset:
Detection of non-metallic landmines using shock impulses and MEMS sensors (1998)

We describe an experimental and theoretical project centered on the use of nonlinear acoustic shock impulses and microelectromechanical systems (MEMS) sensors to detect and image buried, regular-shaped inclusions at various depths in soil. The use of shock waves is partly motivated by the perceived limited capability of conventional acoustic delivery modes, and by recent research which shows that shock impulses travel efficiently in granular media.
uPA deficiency exacerbates muscular dystrophy in MDX mice (vol 178, pg 1039, 2007) (2007)

status: Published
Assessment of the Fragment Docking Program SEED (2020)

The fragment docking program solvation energy for exhaustive docking (SEED) is evaluated on 15 different protein targets, with a focus on enrichment and the hit rate. It is shown that SEED allows for consistent computational enrichment of fragment libraries, independent of the effective hit rate. Depending on the actual target protein, true positive rates ranging up to 27% are observed at a cutoff value corresponding to the experimental hit rate. The impact of variations in docking protocols and energy filters is discussed in detail. Remaining issues, limitations, and use cases of SEED are also discussed. Our results show that fragment library selection or enhancement for a particular target is likely to benefit from docking with SEED, suggesting that SEED is a useful resource for fragment screening campaigns. A workflow is presented for the use of the program in virtual screening, including filtering and postprocessing to optimize hit rates.
Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes (2017)

The transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants and/or by shedding. Soluble CD83 (sCD83) was shown to be involved in negatively regulating the immune response. sCD83 inhibits T cell proliferation in vitro, supports allograft survival in vivo, prevents corneal transplant rejection, and attenuates the progression and severity of autoimmune diseases and experimental colitis. Although sCD83 binds to human PBMCs, the specific molecules that bind sCD83 have not been identified. In this article, we identify myeloid differentiation factor-2 (MD-2), the coreceptor within the TLR4/MD-2 receptor complex, as the high-affinity sCD83 binding partner. TLR4/MD-2 mediates proinflammatory signal delivery following recognition of bacterial LPSs. However, altering TLR4 signaling can attenuate the proinflammatory cascade, leading to LPS tolerance. Our data show that binding of sCD83 to MD-2 alters this signaling cascade by rapidly degrading IL-1R-associated kinase-1, leading to induction of the anti-inflammatory mediators IDO, IL-10, and PGE<sub>2</sub> in a COX-2-dependent manner. sCD83 inhibited T cell proliferation, blocked IL-2 secretion, and rendered T cells unresponsive to further downstream differentiation signals mediated by IL-2. Therefore, we propose the tolerogenic mechanism of action of sCD83 to be dependent on initial interaction with APCs, altering early cytokine signal pathways and leading to T cell unresponsiveness.
Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc 1 4GlcNAc 1 R in both N- and O-glycans (2001)

Recently, cDNAs encoding human chondroitin 4-O-sulfotransferase-1 and -2 (C4ST-1 and C4ST-2) were cloned based on their similarity to HNK-1 sulfotransferase (HNK-1ST) (Hiraoka, N., Nakagawa, H., Ong, E., Akama, T.O., Fukuda, M.N., and Fukuda, M. [2000] Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. J. Biol. Chem., 275, 20188--20196). In the present study, we identified two additional novel sulfotransferases by searching the expression sequence tag and genomic DNA database for enzymes similar to C4ST-1 and C4ST-2. These newly cloned enzymes, termed GalNAc4ST-1 and GalNAc4ST-2, belong to the HNK-1ST gene family having 40--42% identity with C4ST-1. GalNAc4ST-1 and -2 do not add sulfate to HNK-1 precursor glycans, chondroitin, or desulfated dermatan sulfate. Instead, both enzymes can transfer sulfate to the 4-position of GalNAc in the context of GalNAc beta 1-->4GlcNAc beta 1-->R attached to both N-linked and core 2 branched O-linked oligosaccharides. GalNAc4ST-1 and -2 transcripts are highly expressed in the pituitary gland and trachea, respectively, and GalNAc4ST-1 and -2 transcripts are reciprocally expressed in other tissues as well. Moreover, both enzymes can transfer sulfate to lutropin, a pituitary glycoprotein hormone. These combined results indicate that GalNAc4ST-1 and -2 play critical roles in forming sulfo-->4GalNAc beta 1-->4GlcNAc beta 1-->R in both N-glycans and O-glycans in a tissue-specific manner.
A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery (2010)

ClinicalTrials.gov ID: NCT00958581.
Unique Games hardness of Quantum Max-Cut, and a conjectured vector-valued Borell's inequality (2021)

The Gaussian noise stability of a function $f:\mathbb{R}^n \to \{-1, 1\}$ is the expected value of $f(\boldsymbol{x}) \cdot f(\boldsymbol{y})$ over $ρ$-correlated Gaussian random variables $\boldsymbol{x}$ and $\boldsymbol{y}$. Borell's inequality states that for $-1 \leq ρ\leq 0$, this is minimized by the halfspace $f(x) = \mathrm{sign}(x_1)$. In this work, we generalize this result to hold for functions $f:\mathbb{R}^n \to S^{k-1}$ which output $k$-dimensional unit vectors. Our main conjecture, which we call the $\textit{vector-valued Borell's inequality}$, asserts that the expected value of $\langle f(\boldsymbol{x}), f(\boldsymbol{y})\rangle$ is minimized by the function $f(x) = x_{\leq k} / \Vert x_{\leq k} \Vert$, where $x_{\leq k} = (x_1, \ldots, x_k)$. We give several pieces of evidence in favor of this conjecture, including a proof that it does indeed hold in the special case of $n = k$. As an application of this conjecture, we show that it implies several hardness of approximation results for a special case of the local Hamiltonian problem related to the anti-ferromagnetic Heisenberg model known as Quantum Max-Cut. This can be viewed as a natural quantum analogue of the classical Max-Cut problem and has been proposed as a useful testbed for developing algorithms. We show the following, assuming our conjecture: (1) The integrality gap of the basic SDP is $0.498$, matching an existing rounding algorithm. Combined with existing results, this shows that the basic SDP does not achieve the optimal approximation ratio. (2) It is Unique Games-hard (UG-hard) to compute a $(0.956+\varepsilon)$-approximation to the value of the best product state, matching an existing approximation algorithm. (3) It is UG-hard to compute a $(0.956+\varepsilon)$-approximation to the value of the best (possibly entangled) state.
204 KSQ-004: Unbiased pair-wise discovery of SOCS1 and Regnase-1 as the top CRISPR/Cas9 dual-edit combination enhancing in vivo TIL potency against solid tumors (2021)

<h3>Background</h3> The application of CRISPR/Cas9-gene-editing to enhance the anti-tumor activity of T cell Adoptive Cell Therapies (ACT) is a promising approach in the treatment of patients with solid tumors. We developed an in vivo CRISPR^2 screening approach and interrogated the top dual-edit combinations enhancing T cell anti-tumor function. We discovered that across all possible dual-edit combinations of T cell targets, inactivation of Regnase-1 and SOCS1 led to the greatest enhancement in anti-tumor T cell potency in vivo. We applied these findings to discover KSQ-004, a Regnase-1/SOCS1 dual-edited human CRISPR/Cas9-engineered TIL (eTIL) therapy currently under development for therapeutic use. <h3>Methods</h3> We generated randomly paired CRISPR guide libraries (CRISPR2) targeting top hits from previous single-gene Immune CRISPRomics® screens. CRISPR^2 libraries with over 1200 gene pairs were screened in primary mouse OT1 and PMEL-TCR-Tg-T cells in the relevant syngeneic tumor models. Top dual-edit combinations were then evaluated in the immunotherapy-refractory B16F10 metastatic lung tumor model. The efficacy of the top combo was further evaluated in a mouse TIL model wherein TIL from B16-Ova tumors were expanded and engineered ex vivo and adoptively transferred into tumor bearing hosts for efficacy assessment. <h3>Results</h3> Of the 1200+ combinations tested in the CRISPR^2 screens, the Regnase-1/SOCS1 combination ranked amongst the top dual-edits, with this combination enhancing T cell infiltration into tumors &gt;3500-fold in comparison to controls. Studies conducted in the checkpoint therapy refractory B16F10 lung metastasis model revealed that Regnase-1/SOCS1 dual-edited PMEL-TCR-Tg-T cells conferred remarkable survival benefit relative to controls, significantly extending median survival of animals from 21 days to 53 days. Furthermore, Regnase-1+SOCS1-edited mouse TIL isolated and expanded from B16-Ova tumors exerted complete control of tumors upon re-infusion into hosts, suggesting rejuvenation of tumor-experienced TILs by this edit combination. To apply these insights for therapeutic use, we discovered KSQ-004, a human Regnase-1/SOCS1 dual-edited CRISPR/Cas9-engineered TIL (eTIL). Methods were developed to manufacture KSQ-004 from melanoma and NSCLC tumor samples, with eTIL demonstrating robust expansion and viability comparable to unedited control TIL with over 90% knockout of both targets. Importantly, KSQ-004 produced elevated IFNγ upon autologous tumor stimulation and exerted greater control of tumor spheroids in vitro. <h3>Conclusions</h3> We used a novel CRISPR^2 screen approach to identify Regnase-1/SOCS1 as the top dual edit combination enhancing T cell function in the tumor microenvironment. We translated these findings to therapeutic use with the discovery of KSQ-004, a dual-edited eTIL therapy engineered that possesses enhanced anti-tumor potency and persistence against solid tumors.
A Parallel Computer as a NOC Region (2005)

A network on chip (NOC) scheme relying on reuse of existing intellectual property blocks and a unified communication solution has been proposed for solving architectural and design productivity problems of future systems on chips. A NOC consists of a set of heterogeneous computing and storage resources that are connected to each other via a standardized communication network. A heterogeneous structure is suitable for application specific computing, but not for high-speed general purpose computing that is increasingly used in devices that will be powered by NOCs. General purpose functionality can, however, be provided by dedicating the whole chip or a special area on a heterogeneous NOC, called region, for a homogeneous general purpose computing engine. Unfortunately the architectures proposed for NOCs and on-chip parallel computers feature poor performance and portability, or are difficult to program in general purpose computing due to limited communication bandwidth, inability to eliminate delays caused by the latency of the network, high communication overheads, and poor models of parallel computing. In this chapter we will discuss the problems and solutions of implementing an efficient single chip general purpose parallel computing engine. We will also describe our ECLIPSE architecture that can be used either as a truly scalable, high-speed, single chip parallel computer or as a NOC region responsible of general-purpose computation.
A Novel Product-Level Human Metal Model Characterization Methodology (2014)

A new methodology for characterizing product-level failures due to the human metal model (HMM) stress is proposed and developed. This characterization framework is superior to the conventional leakage current-based approach, and it enables early wafer-level assessment of integrated circuits' HMM robustness. The new method is demonstrated in two amplifiers and is benchmarked versus the conventional leakage current method and the industry standard system-level IEC gun testing.
Metallocene-catalyzed alkene polymerization and the observation of Zr-allyls (2006)

Single-site polymerization catalysts enable exquisite control over alkene polymerization reactions to produce new materials with unique properties. Knowledge of catalyst speciation and fundamental kinetics are essential for full mechanistic understanding of zirconocene-catalyzed alkene polymerization. Currently the effect of activators on fundamental polymerization steps is not understood. Progress in understanding activator effects requires determination of fundamental kinetics for zirconocene catalysts with noncoordinating anions such as [B(C6F5)4]-. Kinetic NMR studies at low temperature demonstrate a very fast propagation rate for 1-hexene polymerization catalyzed by [(SBI)Zr(CH2SiMe3)][B(C6F5)4] [where SBI is rac-Me2Si(indenyl)2] with complete consumption of 1-hexene before the first NMR spectrum. Surprisingly, the first NMR spectrum reveals, aside from uninitiated catalyst, Zr-allyls as the sole catalyst-containing species. These Zr-allyls, which exist in two diastereomeric forms, have been characterized by physical and chemical methods. The mechanism of Zr-allyl formation was probed with a trapping experiment, leading us to favor a mechanism in which Zr-polymeryl undergoes beta-H transfer to metal without dissociation of coordinated alkene followed by sigma-bond metathesis to form H2 and Zr-allyl. Zr-allyl species undergo slow reactions with alkene but react rapidly with H2 to form hydrogenation products.
Innovative forum theatre on dementia in a care home setting (2022)

Background: With the ageing population in the UK, we have found a rising number of our patients are being diagnosed with dementia [1] and a significant proportion live in care homes. Education to care home staff to help support these residents has been inconsistent despite a need to continue to improve skills managing residents with dementia [2]. Methods: We developed an interactive training event, ‘Communication in Dementia’, based on the learning needs from a local care home. We opted to use Forum Theatre as a tool to deliver this training. Forum Theatre is where a challenging real-life scenario is dramatised by actors using a pre-written script in front of a group of participants. The group is then facilitated to reflect on what they have observed and explore solutions in a safe environment. This method has been applied successfully in teaching of healthcare professionals such as in nurse education, but its use in the care home setting is uncommon [3]. Despite offering and confirming places to twelve care workers for a two-hour in-person session, only four were able to attend the session on the day. We collected pre- and post-session qualitative and quantitative feedback from the care workers and a written ethnographic reflection of the session. Results: Prior to this session, none of the care workers had experience of Forum Theatre. After the session, the feedback received was positive, particularly about the interactive element of the session, demonstrating how the use of Forum Theatre created an enjoyable and valuable learning experience and that all of the care workers felt more confident communicating with residents with dementia after the session. Thematic analysis of the care worker responses in the ethnographic data recorded demonstrated themes including building meaningful connections with residents and recognising burnout in care workers. Conclusion: We believe that the use of Forum Theatre to teach Communication in Dementia creates an insightful learning experience for care workers, promoting active involvement in the session. We were disappointed that so few care workers were relieved from duties to attend the session on the day. This may indicate the pressures that the workforce are experiencing. We hope that in sharing the learning from this event, we may promote the use of Forum Theatre in care homes as a means of developing care workers to enhance their skills and ultimately to improve the experience of residents with dementia in care homes. References 1. Wittenberg R, Hu B, Barraza-Araiza L, Rehill A. Projections of older people with dementia and costs of dementia care in the United Kingdom, 2019–2040. London: London School of Economics. 2019 Nov. 2. Smith SJ, Parveen S, Sass C, Drury M, Oyebode JR, Surr CA. An audit of dementia education and training in UK health and social care: a comparison with national benchmark standards. BMC health services research. 2019;19(1):1–9. 3. Middlewick Y, Kettle TJ, Wilson JJ. Curtains up! Using forum theatre to rehearse the art of communication in healthcare education. Nurse education in practice. 2012;12(3):139–42.
Immunogenetics of juvenile chronic arthritis in Israel. (1986)

Typing for HLA-A,B,C and DR antigens was performed in 61 Israeli patients with juvenile chronic arthritis (JCA) and in 120 unrelated controls. No significant associations were apparent in the overall patient group. DR5 was significantly increased in the non-Ashkenazi patients with pauciarticular onset of disease. The only three DRw8 positive patients in the study had pauciarticular onset. DR5 and DRw8 were found in 9 of 10 patients with age of onset less than 3 years. Increased frequencies of Bw50 and Cw6 were observed in patients with systemic onset. Typing for properdin factor (Bf) and glyoxylase (GLO) was carried out in 45 and 50 of the patients, respectively. No associations with alleles of the complement Bf system or the HLA linked GLO system were evident. The confirmation in the ethnically distinct Israeli population of the previously described association of DR5 with pauciarticular JCA suggests that this gene may be closely related to the disease susceptibility gene.
Opportunistic spectrum access in TVWS: A comparative coexistence study for LTE (2012)

In this paper, we study the coexistence issues of LTE systems operating in the TV white spaces. The study includes a proposal for an appropriate system design as well as a discussion on the LTE system's self-configurability to avoid potential interference to other systems when the resource allocation is made flexible. This is evaluated in terms of achievable PHY-layer throughput and block error rates (BLER) in coexistence scenarios with digital terrestrial TV (DTT) and wireless microphones (WM). Furthermore, the study makes exclusive comparisons between the current LTE PHY interface of cyclic-prefix OFDM (CP-OFDM) and one of its alternatives, the offset-QAM OFDM (OQAM-OFDM) scheme. Therefore, the aspects of interference robustness, system flexibility and complexity issues are considered. The main outcome of this study is that an LTE system based on OQAM-OFDM offers higher data rates and conforms better to potential regulatory rules than the current CP-OFDM implementation. The OQAM-OFDM scheme is significantly more robust and delivers higher data rates, in particular for the coexistence with narrow-band services. Finally, through the complexity analysis, we conclude that such performance-complexity trade-off may be reasonable in the future as the overall system complexity of OQAM-ODFM is only incremental.
Is it a SmartNIC or a Key-Value Store? (2017)

poster Free Access Share on Is it a SmartNIC or a Key-Value Store?: Both! Authors: Giuseppe Siracusano University of Rome, Tor Vergata University of Rome, Tor VergataView Profile , Roberto Bifulco NEC Laboratories Europe NEC Laboratories EuropeView Profile Authors Info & Claims SIGCOMM Posters and Demos '17: Proceedings of the SIGCOMM Posters and DemosAugust 2017 Pages 138–140https://doi.org/10.1145/3123878.3132014Published:22 August 2017Publication History 7citation959DownloadsMetricsTotal Citations7Total Downloads959Last 12 Months197Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Development of a dissolved oxygen improvement system for dam lake (2017)

Lower to middle tier regions of dam reservoirs often fall into the anoxic states in summer. When the anoxic state is reached, living things die, heavy metals such as manganese and iron, hydrogen sulfide and methane are eluted from mud deposited on the lakebed. Since it is not possible to release heavy metals exceeding environmental standards, an improvement of dissolved oxygen concentration in dam lakebed is required. So far, there is no system that can automatically improve the dissolved oxygen, in the lower to middle tier regions of dam lakebed. This study was carried out for developing an automatic system to improve the lakebed dissolved oxygen concentration to 6mg/L or more. The developed oxygen dissolution apparatus can diffuse a high concentration oxygen water horizontally at a rate of 1km per day. Thus, by raising and lowering this oxygen dissolution apparatus in water, a system that creates 3 - dimensional spreading of the dissolved oxygen not only to the lower tier but also to the middle tier regions was developed. The demonstration experiments, reported of the effectiveness of the system that can raise the dissolved oxygen concentration from the low oxygen-free state to the target of 10 mg / L in 5 days. Moreover, the system demonstrated its ability to automatically raise the dissolved oxygen concentration to 10mg/L in the 10m region from the bottom of lakebed.
Aqueous Synthesized Nanostructured Li4Ti5O12for High-Performance Lithium Ion Battery Anodes (2013)

Nanostructured Li4Ti5O12 (LTO) was prepared via a novel process comprising low-temperature (<100°C) aqueous synthesis and annealing of the hydrous intermediate phase Li1.81H0.19Ti2O5·2H2O (LTH) using only LiOH and TiCl4 as precursors. Nanosheet-structured LTH converted to either LTO nanosheets (102 m2·g−1) or LTO nanoparticles (28 m2·g−1) upon annealing at 400 and 600°C respectively, each exhibiting unique electrochemical performance properties. The nanosheet-structured LTO exhibited higher initial charge capacity (228.3 vs. 187.3 mAh ·g−1 at 1.0 V cutoff and C/24 rate) than the nanoparticle-structured LTO. Furthermore, the LTO nanosheets taking advantage of their short diffusion path exhibited better rate capability than the LTO nanoparticles; for example their discharge capacity at 15 C was 115 mAh ·g−1 vs. 68.4 mAh ·g−1 at 1.2 V cutoff for the LTO nanoparticles. Meanwhile, the LTO nanoparticles exhibited better cyclability than the LTO nanosheets because of their higher crystallinity. Thus after 130 1 C cycles with cut off at 1.2 V (vs. Li/Li+), the discharge capacity of the nanosheets was 132.9 mAh ·g−1 while that of nanoparticles was 150.7 mAh ·g−1, corresponding to 85 and 97% discharge capacity retention respectively. The newly synthesized nanostructured LTO material can offer a low cost scalable solution for high-performance LIB anodes.