gebhart/patrepeval huggingface dataset:
Ligand Redistribution Reactions of Five-Coordinate d6 Species: RuHX(CO)P2, IrH2XP2, and Cp*RuXP (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand Redistribution Reactions of Five-Coordinate d6 Species: RuHX(CO)P2, IrH2XP2, and Cp*RuXPJason T. Poulton, Bryan E. Hauger, Roger L. Kuhlman, and Kenneth G. CaultonCite this: Inorg. Chem. 1994, 33, 15, 3325–3330Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ic00093a021https://doi.org/10.1021/ic00093a021research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A systematic methodology to design analog predistortion linearizer for dual inflection power amplifiers (2011)

This paper presents a systematic methodology to design a diode-based RF predistortion linearizer that can be used to linearize power amplifiers with dual inflection points in their distortion characteristics. The proposed structure contains anti parallel configuration of Schottky diodes, complemented with a PIN diode in parallel, connected to through and coupled ports of a 90° hybrid coupler using λ/4 transmission lines. The use of a PIN diode in the linearizer provides it with an extra level of freedom in achieving the desired level of amplitude and inflection depth in the AM/AM characteristic. A systematic design procedure using this configuration is proposed and applied to linearize a commercial power amplifier. Two tone test experimental results show that the IM3 cancellation of 10 dB in 1 MHz separation between tones at 2.14 GHz can be achieved.
Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging (2021)

ABSTRACT Neural circuit assembly features simultaneous targeting of numerous neuronal processes from constituent neuron types, yet the dynamics is poorly understood. Here, we use the Drosophila olfactory circuit to investigate dynamic cellular processes by which olfactory receptor neurons (ORNs) target axons precisely to specific glomeruli in the ipsi- and contralateral antennal lobes. Time-lapse imaging of individual axons from 28 ORN types revealed a rich diversity in extension speed, innervation timing, and ipsilateral branch locations, and identified that ipsilateral targeting occurs via stabilization of transient interstitial branches. Fast imaging using adaptive optics- corrected lattice light-sheet microscopy showed that upon approaching target, many ORN types exhibit “exploring branches” consisted of parallel microtubule-based terminal branches emanating from an F-actin-rich hub. Antennal nerve ablations uncovered essential roles for bilateral interactions in contralateral target selection, and for ORN axons to facilitate dendritic refinement of postsynaptic partner neurons. Altogether, these observations provide cellular bases for wiring specificity establishment.
Molecular identification of the wheat male fertility gene Ms1 and its prospects for hybrid breeding (2017)

Abstract The current rate of yield gain in crops is insufficient to meet the predicted demands. Capturing the yield boost from heterosis is one of the few technologies that offers rapid gain. Hybrids are widely used for cereals, maize and rice, but it has been a challenge to develop a viable hybrid system for bread wheat due to the wheat genome complexity, which is both large and hexaploid. Wheat is our most widely grown crop providing 20% of the calories for humans. Here, we describe the identification of Ms1 , a gene proposed for use in large-scale, low-cost production of male-sterile ( ms ) female lines necessary for hybrid wheat seed production. We show that Ms1 completely restores fertility to ms1d , and encodes a glycosylphosphatidylinositol-anchored lipid transfer protein, necessary for pollen exine development. This represents a key step towards developing a robust hybridization platform in wheat.
On Shared Risk Link Group Optimization (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Li, D. Wang, T. Gallivan, and R. Doverspike, "On Shared Risk Link Group Optimization," in National Fiber Optic Engineers Conference, OSA Technical Digest (Optica Publishing Group, 2012), paper NW3K.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Microarchitectural techniques for power gating of execution units (2004)

Leakage power is a major concern in current and future microprocessor designs. In this paper, we explore the potential of architectural techniques to reduce leakage through power-gating of execution units. This paper first develops parameterized analytical equations that estimate the break-even point for application of power-gating techniques. The potential for power gating execution units is then evaluated, for the range of relevant break-even points determined by the analytical equations, using a state-of-the-art out-of-order superscalar processor model. The power gating potential of the floating-point and fixed-point units of this processor is then evaluated using three different techniques to detect opportunities for entering sleep mode; ideal, time-based, and branch-misprediction-guided. Our results show that using the time-based approach, floating-point units can be put to sleep for up to 28% of the execution cycles at a performance loss of 2%. For the more difficult to power-gate fixed-point units, the branch misprediction guided technique allows the fixed-point units to be put to sleep for up to 40% more of the execution cycles compared to the simpler time-based technique, with similar performance impact. Overall, our experiments demonstrate that architectural techniques can be used effectively in power-gating execution units.
A Role for Water Molecules in DNA−Ligand Minor Groove Recognition (2008)

Targeting the minor groove of DNA through binding to a small molecule has long been considered an important molecular-recognition strategy in biology. A wide range of synthetic heterocyclic molecules bind noncovalently in the minor groove of the double helix and are also effective against a number of human and animal diseases. A classic structural concept, the isohelicity principle, has guided much of this work: such heterocyclic molecules require a shape that complements the convex surface of the minor groove. Researchers have used this principle to design molecules that can read DNA sequences. This principle also predicts that molecules that lack the complementary shape requirement would only bind weakly to DNA. Recently, however, researchers have unexpectedly found that some essentially linear compounds, which do not have this feature, can have high DNA affinity. In this Account, we discuss an alternative recognition concept based on these new findings. We demonstrate that highly structured water molecules can play a key role in mediating between the ligand and DNA minor groove without loss of binding affinity. Combined structural and thermodynamic approaches to understanding the behavior of these molecules have shown that there are different categories of bound water in their DNA complexes. For example, application of this water-bridging concept to the phenylamidine platform has resulted in the discovery of molecules with high levels of biological activity and low nonspecific toxicity. Some of these molecules are now in advanced clinical trials.
The characterization of the effect of locally applied N‐methylquipazine, a 5‐HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: An in vivo microdialysis study (1996)

In this study, we examined the effect of n-methylquipazine (NMQ), which is a putative 5-hydroxytryptamine, (5-HT3) receptor agonist, on the extracellular concentrations of dopamine (DA) and one of its metabolites, dihydroxyphenylacetic acid (DOPAC), in the anterior medial prefrontal cortex (AmPFc) of awake, freely moving rats. The administration of NMQ via the perfusion fluid produced a concentration-dependent (10-1,000 μM) increase in extracellular DA levels in the AmPFc. In contrast, NMQ produced a decrease in the extracellular concentrations of DOPAC. The increase in extracellular DA levels returned to baseline after the removal of NMQ from the perfusate. The increase in extracellular DA levels in the AmPFc produced by 100 μM of NMQ was markedly attenuated by either the coadministration of tetrodotoxin (1 μM), which inhibits axonal impulse flow, or the depletion of extracellular Ca2+ by removing CaCl2 and adding EDTA to the perfusate. The intradialysate administration of the 5-HT3 antagonist BRL 46470A produced a concentration-dependent (10-1,000 μM) decrease in extracellular DA levels, and this effect was reversible on removal from the perfusate. In contrast, ondansetron (500 and 1,000 μM), which is another 5-HT3 receptor antagonist, produced a transient increase followed by a sustained decrease in extracellular DA levels. The preinfusion of 10 μM of BRL 46470 followed by coperfusion of BRL 46470A with 50 or 100 μM of NMQ via the dialysis probe did not significantly attenuate the increase of NMQ in extracellular DA levels in the AmPFc. The administration of the selective 5-HT2 receptor MDL 100907 (1 mg/kg, i.p.) also did not alter the increase in basal DA levels produced by 100 μM of NMQ. The pretreatment of rats with α-methyl-p-tyrosine produced a significant attenuation in the NMQ-induced increase in extracellular DA levels, suggesting that the elevation by NMQ of DA levels is dependent on newly synthesized stores of DA. Overall, these results suggest that the increase in AmPFc DA levels by NMQ is probably not mediated by its interaction with the 5-HT3 receptor. © 1996 Wiley-Liss, Inc.
The impact of DC bias current on the modeling of lithium iron phosphate and lead-acid batteries observed using electrochemical impedance spectroscopy (2014)

This paper deploys electrochemical impedance spectroscopy (EIS) to investigate the impact of temperature and dc bias current on battery impedance characteristics. Measured test results are used to demonstrate that, under conditions where the nonlinear Butler-Volmer equation is necessary to model the electrode charge transfer characteristics, the semicircular trajectory that typically appears in the EIS results shrinks in diameter as the battery's dc bias current increases. For a lithium-based battery, the nonlinearity introduced by the Butler-Volmer relationship is more pronounced at low temperature, while lead-acid batteries typically exhibit this nonlinearity even at room temperature. The impact of dc bias current on the battery model and EIS characteristics are thoroughly investigated using a combination of experimental tests combined with theoretical justification based on the Arrhenius equation. The value of using this observed relationship to improve the accuracy of battery models and condition monitors (e.g., state-of charge, etc.) is discussed in the paper.
Altered response to growth rate changes inKluyveromyces lactisversusSaccharomyces cerevisiaeas demonstrated by heterologous expression of ribosomal protein 59 (CRY1) (1991)

We report the cloning, characterization and preliminary analysis of the regulation of the gene coding for ribosomal protein 59 (RP59) from the budding yeast Kluyveromyces lactis. The RP59 gene is present as a single copy, contains an intron within the amino terminal coding portion of the gene, and harbors conserved S. cerevisiae splicing signals. Sequence elements upstream of the transcriptional start site are homologous to UASRPG, known to regulate the transcription of numerous genes in S. cerevisiae via their interaction with the trans-activating factor RAP1. These elements are necessary for transcription of RP59 in both K.lactis and S.cerevisiae hosts. UASRPG in S.cerevisiae rp genes also modulate the transcription of rp RNA synthesis in response to a growth rate upshift. In K.lactis, the RP59 gene does not respond to growth rate upshift. Reciprocal expression of RP59 and CRY1 in heterologous hosts demonstrates that glucose upshift occurs in S.cerevisiae but not K.lactis. These results demonstrate that a factor or factors required for growth upshift are lacking in K.lactis, and provide further evidence that the UASRPG are sufficient signals for modulating this response.
Supplementary Table S1 from A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA (2023)

&lt;p&gt;Supplementary Table S1.The PCR condition and sequences of the primer and the fluorescent probe used in this study.&lt;/p&gt;
Toxic Effects of Patulin on Sheep (2006)

The objective of this study was to evaluate the adverse effects of patulin on beef and dairy sheep. In the beef sheep trial, nine Corriedale lambs averaging 26± 3 kg-1 BW were used. The treatment group, n=5, received 3.3 mg patulin/kg-1 BW twice daily (BID) on days 0 through 2; 4.5 mg/kg-1 BW on days 3 through 5, and 5 mg/ kg-1 BW on day 6. Lambs received no patulin from day 7 through 13. The control lambs, n= 4, received an equal volume of water by stomach tube BID. The dry matter (DM) intake in dosed sheep was 22 % less than that of control animals after three days of treatment with 3.3 mg patulin/ kg-1 BW. This difference increased to 40 % as the dose of patulin increased to 5 mg/kg-1 BW. Differences in DM consumption remained significant through day 13 ( P&lt; 0.01). After 6 days of increasing doses of patulin, the body weight of treated sheep was 89 % of that of the control animals. By the end of the trial, body weight in the patulin group was 86 % of that of the control group. The daily weight gain was lower in treated animals between days 0 to 7; and 0 to 13 (P &lt; 0.05). In the dairy sheep trial, thirteen crossbred F1 or F2 Milkschaw x Corriedale ewes averaging 56 + 6 kg-1 BW were used. The treatment group, n= 7, received 3.3 mg patulin/kg-1 BW divided BID. The control group, n=6, received an equal volume of water by stomach tube BID. Neither changes in body weight nor effects on feed intake were observed in the patulin treated group. Effects on milk production, serum biochemistry, electrolytes, and hematology parameters were not detected. Contrary to what it was expected patulin treatment in almost equal doses shown to be effective for beef sheep failed to influence production and health in dairy sheep. Factors such as age, diet and composition of rumen microflora might have contributed to the difference in behavior.
Machine Learned Mapping of Local EHR Flowsheet Data to Standard Information Models using Topic Model Filtering. (2019)

Electronic health record (EHR) data must be mapped to standard information models for interoperability and to support research across organizations. New information models are being developed and validated for data important to nursing, but a significant problem remains for how to correctly map the information models to an organization's specific flowsheet data implementation. This paper describes an approach for automating the mapping process by using stacked machine learning models. A first model uses a topic model keyword filter to identify the most likely flowsheet rows that map to a concept. A second model is a support vector machine (SVM) that is trained to be a more accurate classifier for each concept. The stacked combination results in a classifier that is good at mapping flowsheets to information models with an overall f2 score of 0.74. This approach is generalizable to mapping other data types that have short text descriptions.
Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines (2011)

Mathematical models predict that the future of epidemics of drug-resistant pathogens depends in part on the competitive fitness of drug-resistant strains. Considering metacyclogenesis (differentiation process essential for infectivity) as a major contributor to the fitness of Leishmania donovani, we tested its relationship with pentavalent antimony (SbV) resistance in clinical lines. Different methods for the assessment of metacyclogenesis were cross-validated: gene expression profiling (META1 and SHERP), morphometry (microscopy and FACS), in vitro infectivity to macrophages and resistance to complement lysis. This was done on a model constituted by 2 pairs of reference strains cloned from a SbV-resistant and -sensitive isolate. We selected the most adequate parameter and extended the analysis of metacyclogenesis diversity to a sample of 20 clinical lines with different in vitro susceptibility to the drug. The capacity of metacyclogenesis, as measured by the complement lysis test, was shown to be significantly higher in SbV-resistant clinical lines of L. donovani than in SbV-sensitive lines. Together with other lines of evidence, it is concluded that L. donovani constitutes a unique example and model of drug-resistant pathogens with traits of increased fitness. These findings raise a fundamental question about the potential risks of selecting more virulent pathogens through massive chemotherapeutic interventions.
ChemInform Abstract: TRANSITION‐METAL‐MEDIATED HYDROGENATION OF CARBON MONOXIDE TO OLEFINS: INTERMEDIACY OF COORDINATED CARBENES (1981)

Abstract Der bimetallische Komplex (III), gebildet bei der Umsetzung des Dimethyl‐Zr(IV)‐Komplexes (I) mit dem W‐dihydrid‐Komplex (II) und CO oder aus Methyl‐n2‐acetyl‐bis‐[cyclopentadienyl]‐Zr und (II), lagert sich in Lösung langsam zu den NMR‐spektroskopisch charakterisierten Produkten, dem Zr‐Komplex (IV) und dem Ethylen‐W‐Komplex (V) um.
8-Cl-Adenosine Inhibits Proliferation and Causes Apoptosis in B-Lymphocytes via Protein Kinase A-Dependent and Independent Effects: Implications for Treatment of Carney Complex-Associated Tumors (2009)

ContextCarney complex, a multiple neoplasia syndrome, characterized primarily by spotty skin pigmentation and a variety of endocrine and other tumors, is caused by mutations in PRKAR1A, the gene that codes for the RIα subunit of protein kinase (PKA). PKA controls cell proliferation in many cell types. The cAMP analogue 8-Cl-adenosine (8-Cl-ADO) is thought to inhibit cancer cell proliferation.
The association of metal air pollutants with lung cancer risk (2006)

4559 Air pollution particulate matter (PM) is associated with lung cancer risk. Copper, iron, nickel, vanadium, and zinc are in airborne PM, and cadmium, nickel, and zinc are in tobacco smoke. Cadmium and nickel, as well as several other metals released into air by industry are human lung carcinogens. We conducted an ecological study to examine the association of industrial air releases for metals with lung cancer incidence in Texas. During 1995-2000, 81,132 lung cancer cases were reported in Texas. We identified metals that: (1) are in airborne PM or tobacco smoke, or are human lung carcinogens, and (2) had consistent Environmental Protection Agency reporting for air releases for multiple counties during 1988-2000. We examined the association of metal air releases with average annual age-adjusted rates for lung and non-small cell lung cancer, and lung adenocarcinoma at the county level. Univariate analysis indicated the following positive associations: (1) zinc with the lung cancer (p = 0.02), non-small cell lung cancer (p
Nitrate uptake by p-phosphonic acid calix[8]arene stabilized graphene (2013)

In situ sonic probe exfoliated graphene sheets in the presence of various concentrations of p-phosphonic acid calix[8]arene are effective in removing nitrate from aquatic effluents, with the efficiency increasing for higher ratios of calixarene to graphite. Mild sonication of the nitrate-adsorbed material releases some nitrate ions back to the effluent.
One "shape" fits all: The orientation bandwidth of contour integration (2014)

The ability of human participants to integrate fragmented stimulus elements into perceived coherent contours (amidst a field of distracter elements) has been intensively studied across a large number of contour element parameters, ranging from luminance contrast and chromaticity to motion and stereo. The evidence suggests that contour integration performance depends on the low-level Fourier properties of the stimuli. Thus, to understand contour integration, it would be advantageous to understand the properties of the low-level filters that the visual system uses to process contour stimuli. We addressed this issue by examining the role of stimulus element orientation bandwidth in contour integration, a previously unexplored area. We carried out three psychophysical experiments, and then simulated all of the experiments using a recently developed two-stage filter-overlap model whereby the contour grouping occurs by virtue of the overlap between the filter responses to different elements. The first stage of the model responds to the elements, while the second stage integrates the responses along the contour. We found that the first stage had to be fairly broadly tuned for orientation to account for our results. The model showed a very good fit to a large data set with relatively few free parameters, suggesting that this class of model may have an important role to play in helping us to better understand the mechanisms of contour integration.