gebhart/patrepeval huggingface dataset:
Scalable and Efficient Geographic Routing in Mobile Ad Hoc Wireless Networks (2014)

We propose and evaluate a scalable position-publish and an accompanying routing protocol which is efficient despite operating with imperfect information regarding the destination's location. The traffic generated by our position-publish protocol fits within the transport capacity of large mobile ad hoc networks (MANETs) with constant communication bandwidth allocated for routing overhead, even as the network size increases. The routing protocol guarantees, with high probability, routes whose lengths are within a constant "stretch" factor of the shortest path from source to destination. The key idea underlying the scalability of the publish protocol is for each potential destination node to send location updates (with frequency decaying with distance) to a subset of network nodes, structured as annular regions around it (the natural approach of updating circular regions in distance-dependent fashion does not scale). The routing protocol must therefore account for the fact that the source and/or relay nodes may not have estimates of the destination's location (or may have stale estimates). Spatial and temporal scaling of protocol parameters are chosen so as to guarantee scalability, route reliability and route stretch, and these analytical design prescriptions are verified using simulations.
Role of human prefrontal cortex in attention control. (1995)

Without a functioning dorsolateral prefrontal cortex, humans are stimulus bound and have little confidence in their ability to interact with the environment. Deficits in inhibitory control of external and internal processes coupled with impaired temporal coding of stimuli and detection capacity for novel events leave the patient functioning in a noisy internal environment without critical spatiotemporal cues. Some of these proposals are similar to those of Nauta (104). Based on connectivity of the prefrontal cortex, Nauta suggested that this region was ideally suited to generate and evaluate internal models of action. It is proposed that, in addition to this generation function, the prefrontal cortex is crucial for detecting changes in the external environment and for discriminating internally and externally derived models of the world. This chapter has described a cascade of deficits that result from damage to the dorsolateral prefrontal cortex. Awareness of the sensory world, and of the apparent stream of internal and external events, is impaired by deficits in novelty detection. Changes in the world, internal or external, may not be noticed in a noisy internal milieu. These deficits contribute to impaired reality monitoring and to a subsequent lack of confidence in behavior. An inability to bridge temporal gaps and temporally sequence internal events, together with deficits in inhibitory control systems, contribute to an impairment in the ability to generate coherent representations of alternate or counterfactual realities.
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 (2021)

In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.
Steric Control of Organic Transformation by a Dendrimer Cage:  Organocobalt Dendrimer Porphyrins as Novel Coenzyme B12 Mimics (2002)

Cobalt(II) complexes of poly(aryl ester) dendrimer porphyrins (m-[Gn]TPP)Co(II) and (p-[Gn]TPP)Co(II) (n = 0-3) underwent AIBN-initiated alkylation (AIBN = 2,2'-azobis(isobutyronitrile)) at the metal center with propargyl alcohol in CDCl(3) at 60 degrees C, where the dendritic substituents did not affect the overall conversion rate but selectivity of the alkylation. With the largest (m-[G3]TPP)Co(II), a single organocobalt(III) species (Co(III)-C(=CH(2))CH(2)OH, 4) was selectively formed in 91% yield, due to a steric protection of 4 by the large dendrimer cage from the access of another molecule of cobalt porphyrin species. In contrast, with other cobalt(II) porphyrins, isomerized compounds such as Co(III)-C(CH(3))=CHOH (5) and Co(III)-CH(CH(3))CHO (6) were formed in addition to 4. A stereochemical investigation with (m-[G3]TPP)Co(II) using AIBN-d(12), in place of nondeuterated AIBN, demonstrated that the alkylation (cobalt(III) hydride addition to propargyl alcohol) is selective to a trans adduct. Results also indicated that this addition step does not involve external activation of propargyl alcohol.
The Bearingless 2-Level Motor (2007)

Several processes in chemical, pharmaceutical, biotechnology and semiconductor industry require contactless levitation and rotation through a hermetically closed chamber wall. This paper presents a novel concept that combines crucial advantages such as high acceleration capability, large air gap and a compact motor setup. The basic idea is to separate a homopolar bearing unit axially from a multipolar drive unit on two different height levels. Hence, the proposed concept is denominated as "bearingless 2-level motor". In this paper, the bearing and drive functionalities are explained in detail and design guidelines are given based on analytic equations and electromagnetic 3D simulations. Furthermore, the influence of non-idealities such as saturation and coupling effects are evaluated and included in the design. Finally, measurements on an experimental prototype exemplify the design considerations and prove the excellent performance of the new concept.
ChemInform Abstract: Ruthenium(II) and Osmium(II) Bis(terpyridine) Complexes in Covalently‐ Linked Multicomponent Systems: Synthesis, Electrochemical Behavior, Absorption Spectra, and Photochemical and Photophysical Properties (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Power Management and SRAM for Energy-Autonomous and Low-Power Systems (2011)

Air-drying and oven-drying are pretreatment processes often used before testing and analyzing various soil characteristics in the laboratory. This study selected three kinds of soil, including red soil, entisol, and alluvial soil, and examined the variation of the Cr(VI) content and Cr bond forms in these soils during air-drying and oven-drying. The results show that when the soil is air-dried in natural environment, the Cr(VI) content decreases with air-drying time. On day 10 of air-drying, the Cr(VI) content in these soils is 22.8∼47.9 % of the initial value. When the soil is oven-dried, the Cr(VI) concentration decays faster; on day 8, the Cr(VI) is no longer detected in these soil samples. When the Cr(VI)-contaminated soil is treated by air-drying and oven-drying, the Cr bond form converts into a more stable form. After oven-drying, the Cr mainly exists in Fe-Mn oxide form, organic bond form, and residual form. The air-drying and oven-drying pretreatment processes of soil reduce the Cr(VI) content and stabilize the Cr bond form. If the laboratory analytic results are applied to risk analysis or remediation strategy planning for chromium-contaminated soil, the toxicity, bioavailability, and mobility of Cr in soil may be underrated.
OS 34-02 CONCENTRATION DEPENDENT EFFECT OF PLASMA RESVERATROL ON CEREBRAL VASODILATOR RESPONSIVENESS (CVR) IN ADULTS WITH TYPE-2 DIABETES MELLITUS (T2DM) (2016)

Objective: Having shown that resveratrol consumption can improve flow mediated dilation of the brachial artery, we tested its effects on CVR to hypercapnia in adults with T2DM, a risk population for cerebrovascular disease and cognitive impairments. Design and Method: In a double-blind crossover trial, 34 adults with T2DM consumed 0, 75, 150 and 300 mg of synthetic trans-resveratrol (one dose per week in random order). Before and 1–2 hr after dosing, transcranial Doppler ultrasound was used to assess CVR to a hypercapnic stimulus (breathing Carbogen gas for 3 min) in the middle (MCA) and posterior (PCA) cerebral arteries. Results: Compared with placebo (0 mg), consumption of single doses of resveratrol resulted in significant within-individual improvements of CVR to hypercapnia in both the MCA (75 mg: 13.8 ± 3.5%, P = 0.001; 150 mg: 8.9 ± 3.5%, P = 0.016; 300 mg: 13.7 ± 3.3%, P > 0.001) and the PCA (75 mg: 13.2 ± 4.5%, P = 0.016). There were no significant differences between doses. Plasma concentrations of total trans-resveratrol following 0, 75, 150 and 300 mg doses were 0, 351 ± 43, 688 ± 84 and 1241 ± 147 ng/mL respectively. Within individuals, plasma resveratrol levels predicted treatment changes in CVR to hypercapnia in the MCA (r = 0.296, P = 0.001) but not in the PCA (r = 0.210; P = 0.081). Conclusions: This study provides the first evidence that resveratrol can improve endothelial vasodilator function in cerebral vessels in adults with T2DM. Although the extent of benefit correlated with plasma resveratrol concentration, maximum improvement (30%) was achieved with the lowest dose used (75 mg). Impaired cerebral vasodilator function has been reported as an independent risk factor for stroke and transient ischaemic attack. Therefore these results justify evaluating the potential for chronic resveratrol supplementation to improve cerebrovascular function in T2DM and other populations at heightened risk of cerebrovascular disease and associated pathologies, including accelerated cognitive decline. Moreover they indicate that benefits may be achievable with modest doses of resveratrol.
A privacy scoring framework: Automation of privacy compliance and risk evaluation with standard indicators (2023)

Personal data have become the key to data-driven services and applications whereas privacy requirements are now strongly imposed by regulations. Meanwhile, people find it difficult to understand whether the services and applications handle personal data to comply with their agreements and regulations. Therefore, the need for privacy indicators, which summarize privacy contents as forms of privacy scoring, labels, etc., has increased to empower the users’ rights by providing understandable information about privacy. For firm privacy indicators, proper criteria and methods for evaluating the level of privacy risks and compliance are required. Accordingly, this paper proposes a privacy scoring framework for services in the context of handling personal data, inspired by six standardized indicators. This paper introduces detailed information on standardized indicators and proposes privacy indicators to quantify privacy scores. Also, this paper proposes methods for evaluating privacy policy based on a set of machine learning-based hierarchical binary classifiers and processes for quantifying the level of privacy risks and compliance from privacy-related information. Through analyzing privacy policies and data access lists of more than 10,000 mobile applications on Google Play Store and investigating case studies on privacy scoring of some mobile applications, this paper shows the feasibility of the proposed framework.
ChemInform Abstract: Efficient One‐Pot Synthesis of JM3100. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Some regioselective cross-coupling reactions of halopyridines and halopyrimidines (2002)

An efficient procedure for cross-coupling of 3-bromopyridine and 4-bromoanisole to various mono- and dichloro heteroaryl compounds—giving the corresponding biaryls in 74–96% yield—is described.
Optical Metrology Terminal for Satellite-to-Satellite Laser Ranging (2022)

Interferometric laser ranging is a powerful enabling technology for high-precision satellite-to-satellite tracking within the context of Earth observation, gravitational wave detection, and formation flying. Since the launch of the gravity field mission GRACE Follow-On in 2018, the onboard Laser Ranging Interferometer has successfully been operating as a technology demonstrator in a low-Earth orbit and has significantly enhanced the measurement accuracy compared to the former microwave instrument. Within the framework of this work, a new design concept for an optical instrument of this type is derived, allowing the location of the reference point and the external beam offset to be tuned independently of the integrated retroreflector. On this basis, optical design and construction of the "Optical Metrology Terminal" are carried out, resulting in a basically flight-representative instrument as it could be used in future gravity field missions. Experimental evaluation on elegant breadboard level demonstrated excellent tolerance against variations of the angle of incidence.
Multi-channel vibrotactile display for teleoperated assembly (2003)

Presents the design and testing of a multi-channel vibrotactile display. It is composed of a cylindrical handle with four embedded vibrating elements driven by piezoelectric beams. Vibrations are transmitted to the hands through arrays of pins. The device was tested in sensory substitution for conveying force information during a teleoperated peg insertion. Results show that the device is effective in reducing peak forces during the insertion task.
Nasal Airway Dimensions in Term Neonates Measured by Continuous Wide-band Noise Acoustic Rhinometry (1997)

The nasal airways of 94 healthy term infants (37-42 weeks gestational age) were examined by continuous wide-band noise acoustic rhinometry under standardized conditions on the second or third day postpartum. Validation of the flexible infant probe on tubular plastic models with dimensions similar to the nasal cavity of newborn infants showed a correlation coefficient of 0.98. The mean and standard deviation (SD) of the total minimal cross-sectional area (TMCA), the distance from the nostril to the MCA (DMCA) and the total volumes between the nostril and 45 mm into the nasal cavity (TVOL45) were 0.20 +/- 0.05 cm2, 0.76 +/- 0.29 cm and 2.14 +/- 0.39 cm3 respectively. In general, both anthropometric and rhinometric mean values were higher in males (n = 52) compared to females (n = 42), and the difference was statistically significant for TMCA and head circumference. We conclude that the technical properties, small size and flexible tube of the miniprobe make it uniquely suited for objective assessment of the nasal airways in infants and small children. The RHIN 2000/2100 miniprobe (S.R. Electronics Aps, Lynge, Denmark) is the first infant probe commercially available, making standardization and comparison of results easier.
FIESTA‐ET: High‐resolution cardiac imaging using echo‐planar steady‐state free precession (2002)

This work describes a technique that combines multishot echo-planar imaging (EPI) with steady-state free precession (SSFP, also known as TrueFISP, FIESTA, and balanced FFE) for multislice, cine MR imaging of the heart. Unlike recently reported methods, the technique presented here (FIESTA-ET) is high-resolution and does not require offline reconstruction or postprocessing. It is therefore suitable for use on standard clinical scanners. FIESTA-ET was compared with conventional FIESTA imaging in 10 volunteers and quantitative analyses of myocardial signal-to-noise ratios (SNR) and ventricular volumes were performed. While providing comparable image quality, FIESTA-ET required half the acquisition time per slice of conventional FIESTA. Because multiple slices could be imaged in a single breathhold, the entire heart could be scanned in less than 2 min. Although the FIESTA-ET images exhibited an unexpected increase (P < 0.0005) in myocardial SNR of 16% over FIESTA, the volumetric measurements showed excellent correlation.
Supplementary Video S4 from MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer (2023)

&lt;p&gt;Supplementary Video S4&lt;/p&gt;
Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults (2022)

Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (<i>n</i> = 70) were compared to controls without a history of musical instrument playing (<i>n</i> = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.
The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. (1994)

We have recently reported that v-Raf forms a native heterocomplex with rat heat shock protein (hsp) 90 and a 50-kDa phosphoprotein (p50) in stably transfected 3Y1 fibroblasts (Stancato, L. F., Chow, Y-H., Hutchison, K. A., Perdew, G. H., Jove, R., and Pratt, W. B. (1993) J. Biol. Chem. 268, 21711-21716). Several members of the nuclear receptor family exist in heterocomplexes containing hsp90 and various members of the immunophilin protein family, including hsp56, an immunophilin of the FK506 binding class (Pratt, W. B. (1993) J. Biol. Chem. 268, 21455-21458). In this work, we have asked if Raf is also associated with an immunophilin. We have immunoadsorbed v-Raf from stably transfected rat 3Y1 fibroblasts and show that the immunoadsorbed v-Raf.hsp90.p50 heterocomplex binds the immunosuppressant drug [3H]FK506. The binding is of high affinity (KD 82 nM) and specific in the sense that it is competed by nonradioactive FK506 and rapamycin but not by cyclosporin A. The [3H]FK506 binding activity is eliminated when the heterocomplex proteins are dissociated from v-Raf. Using the 22W mutant of c-Raf in which the NH2-terminal half has been deleted, we show that the catalytic domain of the kinase is sufficient for the immunophilin association. We have shown that hsp90 and p50 do not bind FK506, and the v-Raf heterocomplex does not contain any of the established FK506-binding proteins. Thus, we propose that Raf is associated with a novel immunophilin.
Identifying High-Risk Triple-Negative Breast Cancer Patients by Molecular Subtyping (2021)

Molecular analysis and subtyping of TNBC may be relevant to identify patients with LAR subtype. These cancers seem to be less sensitive to conventional chemotherapy, and new treatment options, including androgen receptor-blocking agents and immune checkpoint inhibitors, have to be explored.
KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure (2015)

Comparative genomics of virulent Tannerella forsythia ATCC 43037 and a close health-associated relative, Tannerella BU063, revealed, in the latter, the absence of an entire array of genes encoding putative secretory proteases that possess a nearly identical C-terminal domain (CTD) that ends with a -Lys-Leu-Ile-Lys-Lys motif. This observation suggests that these proteins, referred to as KLIKK proteases, may function as virulence factors. Re-sequencing of the loci of the KLIKK proteases found only six genes grouped in two clusters. All six genes were expressed by T. forsythia in routine culture conditions, although at different levels. More importantly, a transcript of each gene was detected in gingival crevicular fluid (GCF) from periodontitis sites infected with T. forsythia indicating that the proteases are expressed in vivo. In each protein, a protease domain was flanked by a unique N-terminal profragment and a C-terminal extension ending with the CTD. Partially purified recombinant proteases showed variable levels of proteolytic activity in zymography gels and toward protein substrates, including collagen, gelatin, elastin, and casein. Taken together, these results indicate that the pathogenic strain of T. forsythia secretes active proteases capable of degrading an array of host proteins, which likely represents an important pathogenic feature of this bacterium.
A Multi-Expression Programming Application to the Design of Planar Antennae (2006)

A method to determine functional relationships between the variable physical dimensions of an antenna and the antenna performance characteristics is presented. By applying multi-expression programming to this data set, optimization with regard to a given criteria can be subsequently performed on the functions instead of performing repeated electromagnetic simulations