gebhart/patrepeval huggingface dataset:
Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry (2020)

The data supplied in this work are related to the research article entitled "Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry" (Phung et al., 2019). This data article describes a powerful analytical platform using native weak cation exchange chromatography coupled to a high-resolution mass spectrometer, charge variant mass spectrometry (CV-MS), to characterize bispecific and mispaired antibody species. Elution order is investigated through analytical methods and molecular modeling in an effort to understand the intrinsic charge, size and shape differences of these molecules.
Lightning Parameters for Engineering Applications (2013)

Parameters for Engineering Applications. The Term of Reference (TOR) for this Working Group is found in Appendix 1. The document can be viewed as an update on previous CIGRE documents on the subject published in 1975 and 1980: Berger, K., Anderson, R.B., and Kroninger, H. 1975. Parameters of lightning flashes. Electra, No. 41, pp. 23-37. Anderson, R.B., and Eriksson, A.J. 1980. Lightning parameters for engineering application. Electra, No. 69, pp. 65-102. Anderson, R.B., and Eriksson, A.J. 1980. A summary of lightning parameters for engineering application, CIGRE 1980 Session, paper 33-06, 12 p. It is also related to the following CIGRE reports: CIGRE WG 33.01, Report 63. Guide to Procedures for Estimating the Lightning Performance of Transmission Lines, October 1991, 61 p. CIGRE TF 33.01.02, Report 94, Lightning characteristics relevant for electrical engineering: Assesment of sensing, recording and mapping requirements in the light of present technological advancements, 1995, 37 p. CIGRE TF 33.01.03, Report 118, Lightning exposure of structures and interception efficiency of air terminals, October 1997, 86 p. CIGRE TF 33.01.02, Report 172, Characterization of lightning for applications in electric power systems, December 2000, 35 p. CIGRE TF C4.404, Report 376, Cloud-to-ground lightning parameters derived from lightning location systems: The effects of system performance, April 2009, 117 p. Traditional lightning parameters needed in engineering applications include lightning peak current, maximum current derivative, average current rate of rise, current risetime, current duration, charge transfer, and specific energy (action integral), all derivable from direct current measurements. Distributions of these parameters presently adopted by CIGRE are based on direct measurements by K. Berger and co-workers in Switzerland, supplemented by less accurate magnetic link measurements to increase the sample size. There also exist more recent direct current measurements obtained using instrumented towers in Austria, Brazil, Canada, Germany, Japan, Russia, and Switzerland, as well as those obtained in several countries using rocket-triggered lightning. Further, modern lightning locating systems report peak currents estimated from measured magnetic or electric field peaks. One of the objectives of present document is to evaluate these new experimental data, along with the old data, to determine their applicability to various engineering calculations. Evaluation includes both instrumental and methodological aspects. Possible geographical, seasonal and other variations in lightning parameters are examined. Additional lightning parameters such as the number of strokes per flash (multiplicity), interstroke interval, number of channels per flash, relative intensity of strokes within a flash, return-stroke speed, and equivalent impedance of the lightning channel, as well as characteristics of continuing currents and M-components are included. More detailed information than before is given about less frequent, but potentially more destructive, positive and bipolar lightning flashes.
[What methods are available to assess quality of life of patients fitted with a pacemaker?]. (2000)

Quality of life (QOL) measurements are one of the main determinants for indication and technologic choice in permanent cardiac pacing. QOL measurements are obtained using questionnaire application. Questionnaire for QOL has to be reliable, comprehensive, sensitive and specific. Pacing mode and pacemakers algorithms have been evaluated by QOL measurements: VVI vs DDD, DDD vs VVIR, AAI vs DDD, fall back, algorithm.... Survival data and costs are also relevant aspects of cardiac pacing evaluation.
Development of an Oil Injection System Optimised to the ABB Double Cone Burner (1999)

Present day land-based gas turbine combustors, operating on oil, must meet strict requirements for emissions (CO, unburned hydrocarbons, particulates, smoke and NOx) and burn stabily without pulsations over a wide range of operating conditions. In addition many engines, such as those produced by ABB, operate with both oil and natural gas fuels either together or independently. This paper concentrates on the development of an oil injection system which is optimised for ABB’s double cone burner (Figure 1) and which does not affect the operation of this burner on natural gas. The development procedure, which involved a coupling of numerical and experimental techniques, is described. The results of the application of this procedure indicate that a simple plain jet atomiser in conjunction with a small quantity of unswirling air admitted at the head of the burner is the best option for this burner.
Synthesis and conformational studies of N-glycosylated analogs of the HIV-1 principal neutralizing determinant (1992)

The principal neutralizing determinant (PND) of HIV-1 is found in the V3 loop of the envelope glycoprotein. Antibodies elicited by peptides from this region, containing the GlyProGlyArgAlaPhe (GPGRAF) sequence, were able to neutralize diverse HIV-1 isolates [Javaherian et al. (1990) Science 250, 1590-1593]. The GPGR tetrapeptide was predicted to adopt a type II beta-turn conformation. Earlier, we showed that glycosylation of synthetic T cell epitopic peptides at natural glycosylation sites stabilized beta-turns [Otvös et al. (1991) Int. J. Pept. Protein Res. 38, 467-482]. To evaluate the secondary structure modifying effect of the introduction of an N-glycosylated asparagine residue and to find a correlation between conformation and a possible PND potential, a series of glycopeptide derivatives, N(sugar) GPGRAFY-NH2 (4a-f), have been prepared, together with the parent peptides GPGRAFY-NH2 (2) and NGPGRAFY-NH2 (3), by solid-phase peptide synthesis [sugars: (a) beta-D-glucopyranosyl (Glc); (b) beta-D-galactopyranosyl (Gal); (c) Glc-beta(1----4)-Glc; (d) 2-acetamido-2-deoxy-beta-D-glucopyranosyl (GlcNAc); (e) 2-acetamido-2-deoxy-beta-D-galactopyranosyl (GalNAc); (f) GlcNAc-beta(1----4)-GlcNAc; sugars are attached through a beta (1----N beta) linkage to asparagine (N).] Peptides 2-4 were characterized by amino acid analysis, reversed-phase HPLC, and fast atom bombardment mass spectrometry. Circular dichroism (CD) and Fourier-transform infrared (FT-IR) spectroscopic studies were performed in trifluoroethanol (TFE) and water (D2O was used in FT-IR experiments). Nonglycosylated peptides showed significantly different CD spectra in aqueous and TFE solution.(ABSTRACT TRUNCATED AT 250 WORDS)
Experimental Observation of Large Chern Numbers in Photonic Crystals (2015)

Despite great interest in the quantum anomalous Hall phase and its analogs, all experimental studies in electronic and bosonic systems have been limited to a Chern number of one. Here, we perform microwave transmission measurements in the bulk and at the edge of ferrimagnetic photonic crystals. Band gaps with large Chern numbers of 2, 3, and 4 are present in the experimental results, which show excellent agreement with theory. We measure the mode profiles and Fourier transform them to produce dispersion relations of the edge modes, whose number and direction match our Chern number calculations.
LTE TDD Mode (2009)

This chapter contains sections titled: Introduction LTE TDD Fundamentals TDD Control Design Semi-persistent Scheduling MIMO and Dedicated Reference Signals LTE TDD Performance Summary References
Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board (2015)

This commentary by the leadership of the North American Society for the Study of Celiac Disease (NASSCD) concerns recent research findings regarding infant feeding practices. Celiac disease has increased markedly in recent decades, and seroprevalence studies indicate that this is a true rise, rather than one due to increased awareness and testing. Prior studies have suggested that infant feeding practices and timing of initial gluten exposure are central to the development of celiac disease. Two recent multicenter randomized trials tested strategies of early or delayed gluten introduction in infants, and neither strategy appeared to influence celiac disease risk. These studies also found that breastfeeding did not protect against the development of celiac disease. While disappointing, these results should spur the study of wider environmental risk factors beyond infant feeding, such as intrauterine and perinatal exposures as well as environmental influences later in life, including drug exposure, microbial infections, and the microbiome. Given that celiac disease can develop at any age, it is imperative to study these proposed triggers so as to elucidate the loss of tolerance to gluten and to develop future intervention strategies.
Photo-crosslinkable hydrogel for guided periodontal tissue regeneration (2015)

Periodontitis is an inflammatory disease which destroys the tooth-supporting attachment apparatus. Guided Tissue Regeneration (GTR) is a technique based on a barrier membrane designed to prevent the wound space colonization by gingival cells. Indeed, these cells, characterized by a faster migration and proliferation rate compared to bone and periodontal ligament cells, could interfere with the regeneration process. In this work, we developed a liquid formulation composed of a mixture of silanized hydroxypropylmethyl cellulose (Si-HPMC) and methacrylated carboxymethyl chitosan (MA-CMCS) able to be photochemically crosslinked in situ leading to hydrogel membrane made of an interpenetrated polymer network (IPN) with a synergistic combination of favorable properties of each polymer network. Si-HPMC was selected to assess the barrier effect against soft tissue gingival invasion and CMCS to control the membrane degradation due to its degradable backbone. The methacrylate grafted chains on CMCS allows a photo-curing in short time using visible light lamp (λ 420-480 nm) already used in dentistry and when vitamin B2 (or riboflavin) is used as photoinitiator. The gel point of the IPN precursor formulation was assessed by rheological measurement under lamp irradiation. Mechanical properties after photocrosslinking were studied. Hydrogel membrane degradation was evaluated by soaking hydrogels in 10 mg/ml lysozyme buffer at 37 °C, which confirmed that the addition of CMCS modified the degradation profile of Si-HPMC hydrogel, as evidenced by the recorded weight loss. The in vitro cytocompatibility was evaluated by neutral red uptake using murine fibroblast (L929) in accordance to ISO 10993-5 specifications. Finally, we studied the barrier effect by culturing human primary gingival fibroblasts or human gingival explants on top of the membrane. Cell infiltration was analyzed with confocal microscopy and histological staining (hematoxylin, eosin Y and safranin (HES)). In the next future, in vivo experiment will be performed to further characterize the material for periodontal regeneration.
CT Urography: Looking beyond the urinary tract! (2018)

Poster: ECR 2018 / C-2217 / CT Urography: Looking beyond the urinary tract! by: A. Mugahid 1, M. A. M. Ayoub1, P. M. A. D. Mohamed Abouelhoda1, A. H. A. H. Ibrahim1, M. M. M. Ashour2, A. M. A. Farag1, R. N. M. Abdalla3, M. A. Abo El Ela1, R. A. M. A. Helal4; 1Cairo/EG, 2Cairo, New Cairo/EG, 3Cairo, ca/EG, 4Cairo- Egypt/EG
ChemInform Abstract: Modified Triphosphates of Carbocyclic Nucleoside Analogues: Synthesis, Stability Towards Alkaline Phosphatase and Substrate Properties for Some DNA Polymerases. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Time-gated Fourier-domain optical coherence tomography (2007)

A novel optical coherence tomography (OCT) system is presented that combines Fourier-domain OCT with incoherent nonlinear time gating. By processing backscattered light in the optical domain, the user can select a restricted depth field of view for improved contrast and acquisition speed. This technique has the additional advantage that imaging is done in the infrared (approximately 1280 nm) but is detected in the visible(approximately 504 nm).
ChemInform Abstract: Catalysis Using Colloidal‐Supported Gold‐Based Nanoparticles (2014)

Abstract Review: 36 refs.
Abstract 2782: Targeted Delivery of Plasmid DNA by Ultrasound Following Acute Angioplasty (2007)

Introduction : Although stents have been shown to be able to deliver therapeutic drugs to the blood vessel wall, safety issues are still a concern. FDA-approved microbubble contrast reagents can be modified to carry therapeutic reagents, as well as DNA, and visualized in vivo by non-invasive ultrasound. Moreover, acoustic parameters can be altered to ``burst” microbubbles and increase cell permeability and reagent penetration into the target tissue. We tested the hypothesis that a reporter gene can be delivered to the vascular wall following balloon angioplasty via ultrasound-triggered microbubble delivery. Methods : Lipid monolayer microbubbles formed by self-assembly during ultrasonic dispersion of decafluorobutane gas in an aqueous micellar mixture of phosphatidylcholine and PEG stearate with rapamycin (0.2 mg/ml). Positively charged microbubbles were coated with plasmid DNA expressing red fluorescent protein (CMV-RFP, 4 ug/ml). Acoustic parameters were optimized in vitro using rat aortic SMCs and applied in vivo in the rat carotid artery balloon injury model. Results : Ultrasound-triggered (8 MHz, Mechanical Index = 1.9) release of CMV-RFP resulted in effective RFP expression. Release of rapamycin (final conc. 10 ng/ml) decreased proliferation by 65% in SMCs maintained in growth media. Microbubbles and/or ultrasound alone did not result in toxicity. CMV-RFP microbubbles were infused (2x10 7 bubbles/min) into the right jugular vein of a rat that had undergone balloon injury. Microbubbles were visualized in the injured left carotid artery by non-invasive ultrasound (Sequoia, Siemens). Using the same acoustic parameters to release reagents in vitro , focused ultrasound was delivered for 5 minutes to the injured blood vessel. 3 days after CMV-RFP delivery, the animal was euthanized and vessels were processed for frozen histological cross sectioning. RFP expression was visible by fluorescence microscopy in the inner-most SMC layer of the injured vessel and not in the contralateral vessel. Conclusion : We demonstrate that CMV-RFP can be delivered to a blood vessel following angioplasty and that this method may be useful for clinical gene therapy as well as potential drug delivery to prevent in-stent restenosis.
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2023)

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was updated to add “P.M” between “P.D.” and “R.C.”. Additionally, the original version of this Article contained the incorrect affiliation for author Patrick Gavin Kehoe, which incorrectly read “German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany”. The correct version replaces this affiliation with “Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK”. This has been corrected in both the PDF and HTML versions of the Article.
Failure of Three Cementless Modular Total Hip Arthroplasty Prostheses: A Retrieval Analysis (2008)

The reasons leading to the in vivo failure of three titanium alloy modular implants in cementless total hip arthroplasty were investigated. The implantation period ranged from 18 months to over three years. Two were fractured in vivo and the other was retrieved secondary to aseptic loosening after 18 months in service. Macroscopic examination showed close topographical similarities between the two fractured implants. Dark elliptical striations on the fractured site indicated the occurrence of low cycle fatigue. Light Microscopy and Scanning Electron Microscopy confirmed the presence of fretting, pitting, plastic deformation, and stress-induced corrosion cracking. In two of the three implants, EDS confirmed metal ion traces in the tissue around the implant. However, nothing unusual was found in the third unfractured implant. Taper performance is influenced by metallurgy, the load carried and the effect of the local microenvironment. Methods to reduce the impact of these factors may reduce the incidence of taper related failure.
Mechanical Properties of Ce0.9Gd0.1O2-δ at High Temperatures under Controlled Atmospheres (2011)

Young's modulus of Ce 0.9 Gd 0.1 O 2-δ (GDC) were investigated as functions of temperature from room temperature to 1273 K and of p(O 2 ) from 10 -24 to 10 -2 bar by using a resonance method. It was found that the Young's modulus of GDC under oxidizing conditions gradually decreased with increasing temperature and was almost independent of p(O 2 ) at a constant temperature. However, under reducing conditions, it apparently decreased as p(O 2 ) decreased even at a constant temperature in the response to the increase in the oxygen nonstoichiometry δ. Such a p(O 2 ) as well as a temperature dependencies of the Young's modulus can be explained by the change in the interatomic distance due to the chemical and/or the thermal expansion.
Effect of group size on pig performance in a wean-to-finish production system. (2001)

Crossbred pigs (n = 1,400) were used to evaluate the effect of group size (25 vs 50 vs 100 pigs/pen) in a wean-to-finish production system on growth performance and carcass measures. Pigs were weaned at 17 d (range = 15 to 19) of age with a mean initial BW of 5.9 +/- 0.02 kg and taken to a final mean pen weight of 116 +/- 0.9 kg. A 10-phase dietary regimen was used, and pigs had free access to feed and water. Feeder-trough space (4.3 cm/pig) and floor-area allowance (0.68 m2/pig) were the same for all group sizes. Compared to groups of 25, pigs in groups of 50 and 100 animals were lighter (P < 0.001) at the end of wk 8 after weaning and had lower (3%, P < 0.01) ADG and gain:feed (G/F) but similar (P > 0.05) ADFI during the first 8 wk of the study. At the end of the study, pig weight and the coefficient of variation in pig weight within a pen were similar (P > 0.05) across group sizes. During the period from 8 wk after weaning to the end of the study, pigs in groups of 100 compared to 50 animals had greater (3%, P < 0.01) ADG, and pigs in groups of 25 were intermediate for ADG. Average daily feed intake during this period was similar (P > 0.05) for all group sizes; however, G/F was greater (3%, P < 0.01) for groups of 100 compared to 25 or 50 animals. For the overall study period, ADG, ADFI, and G/F from weaning to slaughter weight were similar across group sizes (P > 0.05; 655, 648, and 658 g; 1,759, 1,755, and 1,759 g; and 0.37, 0.37, and 0.37; for ADG, ADFI, and G/F, respectively, for groups of 25, 50, and 100 pigs, respectively). Mortality was similar (P > 0.05) across group sizes; however, morbidity (pigs removed due to poor health or injury) was higher in groups of 25 pigs compared to the other two group sizes (7.0, 3.5, and 3.9% for groups of 25, 50, and 100, respectively; P < 0.05). Group-size treatment did not affect (P > 0.05) carcass dressing percentage, backfat thickness, or loin-eye depth. In summary, growth performance from weaning to market weight was not affected by group size.
Low Voltage‐Loss Organic Solar Cells Light the Way for Efficient Semitransparent Photovoltaics (2022)

Organic solar cells that are transparent to visible light are highly desirable for applications such as window treatments or solar greenhouse panels. A key challenge is to simultaneously transmit most photons between 400 and 700 nm while retaining a high short‐circuit current and power conversion efficiency (PCE). Here, organic bulk heterojunction (BHJ) solar cells consisting of a donor polymer (PM2) is reported and the non‐fullerene acceptor ITIC‐Th achieves a PCE of 9.3%, and the BHJ thin films exhibit an average visible transmittance over 40%. This value is achieved primarily due to a very high open‐circuit voltage ( V OC ) of 0.93 V, which represents a voltage loss of only 0.50 V relative to the material optical bandgap, E opt . In PM2:PC 61 BM devices, this voltage loss increases to 0.62 V ( V OC = 0.82 V). It is found that this difference in V OC is due to higher nonradiative recombination in the fullerene‐based solar cell, suggesting that non‐fullerene acceptors may lead to better performance in semi‐transparent devices. The optoelectronic properties associated with PM2:ITIC‐Th and PM2:PC 61 BM blends are further corroborated by different morphological features and local structures at the donor‐acceptor interfaces characterized by atomic force microscopy, X‐ray scattering, and solid‐state NMR spectroscopy techniques.
Cardiovascular Photonics (2006)

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results (2022)

Higher induction regimen was not superior to standard induction regimen, and CA and TDM maintenance strategies were similarly efficacious. Adalimumab therapy was well tolerated, and no new safety concerns were identified. (ClinicalTrials.gov, Number: NCT02065570).
Two Novel Resveratrol Trimers, Leachianols A and B, from Sophora leachiana. (1994)

Two novel resveratrol trimers, named leachianols A (1) and B (2), were isolated from the roots of Sophora leachiana. Their structures were determined by spectroscopy using correlation spectroscopy involving long range coupling and unclear Overhauser effect experiments. The resveratrol trimers 1 and 2, which are formed by characteristics oligomerization via a pallidol (3), are the first naturally occurring oligostilbenes to be reported.
Biodegradable Polymeric Nanoparticles as Drug Carrier for Antitumor Agents (2018)

Entrapment of cytotoxic drugs inside endocytizable carriers such as liposomes improves the specificity of the drug and reduces its toxicity towards non diseased cells. Work in this field has resulted in the development of polyacrylamide nanocapsules. The major advantage of alkylcyanoacrylates over other acrylic derivates which were previously used in the preparation of submicroscopic nano particles lies in the polymerization process of monomers. Unlike other acrylic derivates, the polymerization of which requires an energy liable to hinder the good adsorption of the drug, alkylcyanoacrylates may be polymerized without that energy. Polyalkylcyanoacrylate nanoparticles (PAN) were prepared with and without using surfactive agents at various pH ranging between pH 2.9 and 4.1. The molecular weights of these preparations were determined by an HPLC-GPC chromatography on a Styr-agel column. The drugs to be adsorbed onto the carrier can be dissolved in the polymerization medium before the addition of the alkylcy-anoacrylic monomer or in the already prepared nanoparticle suspension.