gebhart/patrepeval huggingface dataset:
Numerical Modeling and 3D Investigation of INWAVE Device (2017)

In this article, numerical studies on a tightly moored point absorber type wave energy converter called INWAVE are presented. This system consists of a buoy, subsea pulleys, and a power take off (PTO) module. The buoy is moored by three ropes that pass through the subsea pulleys to the PTO module. Owing to the counterweight in the PTO module, a constant tension, which provides a horizontal restoring force to the buoy, is constantly applied to the rope. As waves pass by, the buoy is subjected to six degrees of freedom motion, consisting of surge, heave, sway, roll, pitch, and yaw, which causes reciprocating motion in the three mooring ropes. The PTO module converts the motion of the ropes into electric power. This process is expressed as a dynamic equation based on Newtonian mechanics and the performance of the device is analyzed using time domain simulation. We introduce the concept of virtual torsion spring in order to prevent the impact error in the ratchet gear modules which convert bidirectional motion of rope drum into unidirectional rotary motion. The three-dimensional geometrical relationship between the ropes and the buoy is investigated, and the effects of the angle of the mooring rope and the direction of wave propagation are addressed to determine the interaction between the tension of the rope and the buoy. Results have shown that the mooring rope angle has a large impact on the power extraction. The simulation results present a useful starting point for future experimental work.
Macrophage Delivery of Therapeutic Nanozymes in A Murine Model of Parkinson‘S Disease (2010)

These data support the importance of macrophage-based nanozyme carriage for Parkinson's disease therapies.
Rocio encephalitis (2022)

, Ochleratus. Zonotrichia capensis. . .
High temperature (1000 °C) compatible Y–La–Si–O silicate gate dielectric in direct contact with Si with 7.7 Å equivalent oxide thickness (2011)

Yttrium lanthanum silicate was formed in direct contact with silicon after a rapid thermal annealing at 1000 °C in metal-oxide-semiconductor capacitors leading to an equivalent oxide thickness (EOT) of 7.7 Å. This represents one of the lowest EOT value reported for a gate-first process with non Hf-based dielectric. The silicate is formed by interdiffusion of La2O3 and YOx layers and interfacial SiO2 consumption. Yttrium incorporation reduces the leakage current density as well as the large negative flatband voltage (Vfb) shift that is associated with lanthanide-based dielectrics. The Vfb value can be appropriately tuned for n-type field-effect transistor operation by changing the silicate composition.
Multimetallic Nanoparticles on Mirrors for SERS Detection (2021)

Nanoparticle on mirror (NPoM) architectures are attractive for optical applications–particularly for sensing–due to their simplicity and reliability of their multicomponent plasmonic interactions. However, to date, work has predominantly focused on monometallic nanoparticles on different metallic films. While these studies have investigated the effect of geometry on the optical responses of NPoM structures, understanding the effect of nanoparticle composition is needed to gain a full understanding and complete control over these systems. To elucidate the role of composition on localized plasmonic resonances, a surface-based nanoparticle synthetic method, scanning block copolymer lithography (SPBCL), was used to synthesize and characterize single Au0.5Ag0.5 particles on a five-layer, thermally stable plasmonic mirror substrate. The use of SPBCL is important because it can easily be extended to almost a limitless number of polyelemental systems. We demonstrate the potential of the approach by using surface-enhanced Raman spectroscopy to detect benzene-1,4-dithiol adsorbed onto individual alloyed AuAg NPs in an NPoM geometry.
A monolithic GaAs-on-Si receiver front end for optical interconnect systems (1993)

The authors describe a monolithic technology for integrating GaAs with Si bipolar devices and demonstrate that such integration can provide improved system performance without degrading individual devices. The technology has been used to implement a 1-GHz GaAs/Si optical receiver with an equivalent input noise current density of less than 3 pA/ square root Hz for midband operation, and less than 4.5 pA/ square root Hz at 1 GHz. In this receiver an interdigitated GaAs metal-semiconductor-metal (MSM) photodetector is combined with a transimpedance preamplifier fabricated in silicon bipolar technology. The measured dark current of the GaAs/Si photodetector is 7 nA. The measured pulse response of an experimental integrated receiver is less than 550 ps FWHM. The integrated front end provides a wideband, low-noise optical receiver for use in local optical interconnections and demonstrates the successful application of integrated GaAs-on-Si technology to optoelectronics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparative evaluation of acute toxicity doxorubicin and its in niosomes (2015)

, . , LD50 5,50,7 / 4,00,6 / . , , -14,21,2 / 10,81,0 / . . LD50 , ,
Decoration of ZnO Nanorods with Coral Reefs like NiO Nanostructures by the Hydrothermal Growth Method and Their Luminescence Study (2014)

Composite nanostructures of coral reefs like p-type NiO/n-type ZnO were synthesized on fluorine-doped tin oxide glass substrates by hydrothermal growth. Structural characterization was performed by field emission scanning electron microscopy, high-resolution transmission electron microscopy, and X-ray diffraction techniques. This investigation shows that the adopted synthesis leads to high crystalline quality nanostructures. The morphological study shows that the coral reefs like nanostructures are densely packed on the ZnO nanorods. Cathodoluminescence (CL) spectra for the synthesized composite nanostructures are dominated mainly by a broad interstitial defect related luminescence centered at ~630 nm. Spatially resolved CL images reveal that the luminescence of the decorated ZnO nanostructures is enhanced by the presence of the NiO.
A Cross-Layer Unequal Error Protection Scheme for Prioritized H.264 Video using RCPC Codes and Hierarchical QAM (2013)

We investigate the rate-compatible punctured convolutional (RCPC) codes concatenated with hierarchical QAM for designing a cross-layer unequal error protection scheme for H.264 coded sequences. We first divide the H.264 encoded video slices into three priority classes based on their relative importance. We investigate the system constraints and propose an optimization formulation to compute the optimal parameters of the proposed system for the given source significance information. An upper bound to the significance-weighted bit error rate in the proposed system is derived as a function of system parameters, including the code rate and geometry of the constellation. An example is given with design rules for H.264 video communications and 3.5-4 dB PSNR improvement over existing RCPC based techniques for AWGN wireless channels is shown through simulations.
Regulation of Telomerase by Human Papillomaviruses (2005)

The E6 oncoprotein of human papillomaviruses (HPVs) induces telomerase activity in primary human epithelial cells. This activity is dependent on association of E6 with E6AP, a cellular ubiquitin ligase. E6 activates the transcription of hTERT, the catalytic subunit of telomerase. E boxes near the start of hTERT transcription are required for E6; however, acetylated histones are only present in the E6 cells. We identified two isoforms of NFX1, a new binding partner of E6/E6AP. The NFX1- 91 isoform binds to an X-box motif located adjacent to the proximal E box, binds Sin3A and HDACs, repressing hTERT transcription. It preferentially binds E6/E6AP and is targeted for ubiquitin-mediated degradation. The NFX1-123 isoform has the opposite activity, increasing hTERT transcription or translation. This is the first example of viral oncoproteins disrupting regulation of telomerase, a critical event in tumorigenesis.
Nanoparticle transport pathways into tumors (2018)

Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.
SUPERCONDUCTING CLASSES IN THE EXTENDED HUBBARD MODEL (1996)

This paper describes group theoretical classification of superconducting states (SC) in the extended Hubbard model with on-site repulsion (U), nearest neighbor attraction (V) and nearest neighbour exchange interaction (J) on the two-dimensional square lattice using the mean field approach. By decomposing the pairing interaction into irreducible parts; A 1g , B 1g and E u of D 4h point symmetry, we have derived two singlet SCs (s-wave and d-wave) from A 1g and B 1g , eight triplet SCs from E u . The first three types of triplet SC have pairing by electrons with antiparallel spin, the second two types have pairing by electrons with equal spin and the last three types are non-unitary and have pairing by only up-spin electrons. We showed that three non-unitary states have to be accompanied with a ferromagnetic order from the structure of the maximal little groups. We performed numerical studies for these SCs. For parameters and electron density favorable for the ferromagnetic order, a non-unitary SC coexistent with ferromagnetism is most stable.
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase (2015)

Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that inhibit the cellular activity of oncogenic RET mutants at two digit nanomolar concentration. These three compounds shared a 3-trifluoromethyl-4-methylpiperazinephenyl pharmacophore that stabilizes the 'DFG-out' inactive conformation of RET activation loop. They blocked RET-mediated signaling and proliferation with an IC50 in the nM range in fibroblasts transformed by the RET/C634R and RET/M918T oncogenes. They also inhibited autophosphorylation of several additional oncogenic RET-derived point mutants and chimeric oncogenes. At a concentration of 10 nM, ALW-II-41-27, XMD15-44 and HG-6-63-01 inhibited RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles; they also inhibited proliferation of cancer, but not non-tumoral Nthy-ori-3-1, thyroid cells, with an IC50 in the nM range. The three compounds were capable of inhibiting the 'gatekeeper' V804M mutant which confers substantial resistance to established RET inhibitors. In conclusion, we have identified a type II TKI scaffold, shared by ALW-II-41-27, XMD15-44 and HG-6-63-01, that may be used as novel lead for the development of novel agents for the treatment of cancers harboring oncogenic activation of RET.
Experimental and computational studies of negative near-wall shear stress in the human aorta and its correlation with various stages of CHF (2002)

In this article, we report our in vitro observations demonstrating that reduced blood flow combined with increased heartbeat can lead to a retrograde flow adjacent to the vessel wall and thereby high negative wall shear stress over a major part of cardiac cycle. We attempt to map the correlation between the level of retrograde flow in the descending aorta and the severity of congestive heart failure (CHF), using both experimental methods and computational fluid dynamics (CFD) simulations.
Toxicity of aminoglycoside antibiotics may be due to alternate binding of the human mitochondrial ribosomal RNA (2015)

Aminoglycoside antibiotics are a well-known antibiotic family used to treat various bacterial infections in humans and animals, but unfortunately have significant toxicity. These aminoglycoside antibiotics primarily bind to helix 44 of the bacterial small ribosomal subunit RNA at the tRNA receptor aminoacyl site and, thus inhibit protein synthesis by causing misreading or obstructing the translocation process (1). However, recent findings demonstrate that aminoglycosides bind helix 69 of the large subunit RNA as well. Little is known about the interaction of aminoglycosides with the homologous H69 rRNA hairpin of the human host and which may play a role inaminoglycoside toxicity. To gain insight, we compared aminoglycoside binding to the terminal hairpin ofhuman cytoplasmic, human mitochondrial, and Escherichia coli H69, and human mitochondrial and E. coli H44 using UV-monitored thermal stability analysis, circular dichroism (CD), and NMR structural studies. The UV thermal analysis shows that the overallbinding affinities of gentamicin and kanamycin A to the human cytoplasmic, human mitochondrial, and E. coli H69 were similar. CD and 1H 1D and 2D NMR results indicated that aminoglycoside binding enhances the conformational stability by increasing base stacking on human mitochondrial H69. The greater binding induced stability on human mitochondrial H69 and similar binding affinity to that of E. coli suggest that human mitochondrial H69 may be important to understanding the mechanism of aminoglycoside toxicity.
Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites (2003)

Vascular endothelial growth factors (VEGFs) regulate the development and growth of the blood and lymphatic vascular systems. Of the three VEGF receptors (VEGFR), VEGFR-1 and -2 are expressed on blood vessels; VEGFR-2 is found also on lymphatic vessels. VEGFR-3 is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Although VEGFR-3 is essential for proper lymphatic development, its signal transduction mechanisms are still incompletely understood. Trans-phosphorylation of activated, dimerized receptor tyrosine kinases is known to be critical for the regulation of kinase activity and for receptor interaction with signal transduction molecules. In this study, we have identified five tyrosyl phosphorylation sites in the VEGFR-3 carboxyl-terminal tail. These sites were used both in VEGFR-3 overexpressed in 293 cells and when the endogenous VEGFR-3 was activated in lymphatic endothelial cells. Interestingly, VEGF-C stimulation of lymphatic endothelial cells also induced the formation of VEGFR-3/VEGFR-2 heterodimers, in which VEGFR-3 was phosphorylated only at three of the five sites while the two most carboxyl-terminal tyrosine residues appeared not to be accessible for the VEGFR-2 kinase. Our data suggest that the carboxyl-terminal tail of VEGFR-3 provides important regulatory tyrosine phosphorylation sites with potential signal transduction capacity and that these sites are differentially used in ligand-induced homo- and heterodimeric receptor complexes.
Early Packet Loss Feedback for WebRTC-Based Mobile Video Telephony over Wi-Fi (2015)

We consider improving the performance of WebRTC-based mobile video telephony over a Wi-Fi link, which is susceptible to channel-caused or congestion-caused packet losses. Existing reactive packet loss mitigation mechanisms rely on end-to-end feedback, which takes about one round-trip time (RTT), causing excessive artifacts or video freeze in the received video in typical network scenarios. To address this problem, we propose early packet loss feedback (EPLF), where the MAC layer of the local Wi-Fi link sends a spoofed NACK to the Realtime Transport Protocol (RTP) layer if and only if the transmission failure is caused by a channel error, and the NACK immediately triggers an RTP layer retransmission. This significantly reduces the loss-feedback delay while improving the effectiveness of the RTP-layer congestion control. Analytic modeling and experimental results show that EPLF almost completely eliminates channel-caused video freezes.
Characterization of L-Arabinose Isomerase inBacillus subtilis, a GRAS Host, for the Production of Edible Tagatose (2009)

Abstract L-Arabinose isomerase (AI; E.C. 5.3.1.4), a commercial enzyme for the production of edible tagatose in vitro and ribulose production in vivo, has been studied using enzymes expressed in an Escherichia coli system, which might cause noxious by-products in food. To ensure food safety in the tagatose manufacturing process, we studied an AI expression system in Bacillus subtilis. The AI gene from Geobacillus stearothermophilus (GSAI) was expressed in Bacillus subtilis, a GRAS host used in the production of fermented soybean in Korea, after subcloning into a Bacillus subtilis - E. coli shuttle vector, and was characterized after purification. The activities of the crude enzyme extract and a purified sample were 0.15 U/mg protein and 2.7 U/mg protein, respectively. The optimal pH and the optimal temperature for arabinose and galactose as substrates were pH 8.0 and 60°C, respectively, the same as those for GSAI in an E. coli expression system. Substrate affinities (Km) for arabinose and galactose were 77 mM and 279 mM, respectively, whereas in the E. coli expression system, they were 100 mM and 578 mM, respectively. Catalytic efficiencies (kcat/Km) for arabinose and galactose were 58.3 and 11.4 mM−1 min−1, respectively. The potential use of GSAI expressed in a GRAS host for the production of edible tagatose is discussed in light of these results. Key Words: arabinose isomerasetagatose bioconversionfood safety Bacillus subtilis Escherichia coli ACKNOWLEDGMENT This work was supported by a grant from Korea Research Foundation (KRF2007-F00126) and in part by a grant from the Catholic University of Korea (2007 Research Fund to P. Kim). The authors appreciate Dr. Ki-Sung Kwon in Korea Food and Drug Administration for the helpful discussion.
Supplementary Tables 1-3 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics (2023)

Supplementary Tables 1-3 from Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS (2004)

Prohormone convertase 1 (PC1) is a serine proteinase responsible for the proteolytic processing of many precursor proteins within the regulated secretory pathway. The activity of PC1 is potentially regulated by two endogenous inhibitors, the PC1 propeptide and proSAAS. Here we have investigated the effect of proSAAS and propeptide-containing constructs on PC1 carboxy-terminal processing and activity. In AtT-20 cells, proSAAS expression inhibited both C-terminal PC1 processing and proopiomelanocortin (POMC) processing under pulse/chase conditions. SAAS CT peptide-propeptide chimeric constructs had no effect on the cleavage of PC1 and POMC under pulse/chase conditions. However, a construct containing the propeptide alone reduced C-terminal PC1 processing under pulse/chase conditions and also inhibited POMC processing. In contrast, experiments using HEK293 cells transiently expressing PC1 plus the respective constructs demonstrated significant inhibition of zymogen processing and decreased C-terminal processing of PC1 by the SAAS CT peptide portion of the chimera. Our results suggest that the PC1 propeptide expressed in trans is able to act as an endogenous inhibitor of PC1, but that SAAS CT peptide-containing/propeptide constructs cannot function as effective inhibitors of precursor maturation in the regulated pathway.
A survey of real-time power-loss minimizers for induction motors (2009)

This paper presents a survey of available techniques for minimizing power losses and input power of induction motors. The presented techniques serve different induction motor applications, including electric ship propulsion systems. Real-time techniques presented here are divided into three main categories: model-based methods that use the induction motor model, physics-based methods that search for the minimum power loss regardless of the motor model or parameters, and hybrid methods that combine both approaches. Definitions, comparisons, and details about these methods are presented. To compare model-based and physics-based methods in a propulsion application, simulations of a model-based technique and another physics-based technique are also presented.
Functional connectivity during deep brain stimulation in the subthalamic nucleus of hemiparkinson rats measured with FDG-PET (2016)

217 Objectives Deep brain stimulation in the subthalamic nucleus (DBS-STN) is a successful therapeutic approach to treat motor symptoms of Parkinson9s disease. Because functional network changes underlying DBS STN are not well understood, we combined DBS-STN with functional [18F]FDG-PET in a rat hemiparkinson model. Methods Parkinson-like symptoms were induced by injecting 6-hydroxydopamine (6-OHDA) unilaterally into the medial forebrain bundle (n=7). Automated gait analysis and [18F]FDOPA PET confirmed motor impact and dopaminergic lesion, respectively. In sham operated controls (n=6), saline was injected instead of 6-OHDA. For DBS-STN an electrode was inserted through a chronically implanted guide cannula aiming at the ipsilesional STN. Two weeks after 6-OHDA or saline injection, [18F]FDG (2 mCi) was injected intraperitoneally, and immediately after injection awake and freely moving rats underwent one of two randomized stimulation conditions for 40 minutes: 1) DBS-STN with a pulse rate of 130 Hz (StimON); 2) Without electrode (StimOFF). 60 min after FDG injection, animals were anesthetized and a brain scan was acquired in a small animal PET scanner (Focus 220, Siemens). This procedure was repeated with the other stimulation condition on a different day. Seed-based functional connectivity analysis was performed with intra-individual difference images (StimON minus StimOFF). Results During StimOFF, hemiparkinson rats showed metabolic hypoactivity in the ipsilesional hemisphere as well as contralesional hyperactivity compared to controls. DBS-STN generally increased ipsilateral and decreased contralateral FDG uptake. Significant increases of metabolic activity during StimON were found in the ipsilateral prefrontal cortex, striatum, and deep cerebellar nuclei. FDG uptake decreased during StimON in the contralateral motor cortex, hippocampus, and thalamus. Functional connectivity analyses revealed a complex stimulation-associated bilateral network comprising thalamus, hippocampus, pons, and cerebellum. Striatum and globus pallidus externus formed a separate network, which was connected to the cerebellum via the pretectum. Conclusions Our study shows that DBS-STN normalizes the metabolic imbalance between hemispheres, which was initially caused by the dopaminergic lesion. Key areas were the deep cerebellar nuclei and thalamus, recruiting a network of associated brain regions.
Decision letter: Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome (2018)

Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.