gebhart/patrepeval huggingface dataset:
Search for exotic decays of the Higgs boson into b$$ \overline{b} $$ and missing transverse momentum in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector (2022)

A bstract A search for the exotic decay of the Higgs boson ( H ) into a b $$ \overline{b} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover> <mml:mi>b</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> resonance plus missing transverse momentum is described. The search is performed with the ATLAS detector at the Large Hadron Collider using 139 fb − 1 of pp collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV. The search targets events from ZH production in an NMSSM scenario where H → $$ {\overset{\sim }{\chi}}_2^0{\overset{\sim }{\chi}}_1^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> , with $$ {\overset{\sim }{\chi}}_2^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> → $$ a{\overset{\sim }{\chi}}_1^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>a</mml:mi> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> , where a is a light pseudoscalar Higgs boson and $$ {\overset{\sim }{\chi}}_{1,2}^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mrow> <mml:mn>1</mml:mn> <mml:mo>,</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> are the two lightest neutralinos. The decay of the a boson into a pair of b -quarks results in a peak in the dijet invariant mass distribution. The final-state signature consists of two leptons, two or more jets, at least one of which is identified as originating from a b -quark, and missing transverse momentum. Observations are consistent with Standard Model expectations and upper limits are set on the product of cross section times branching ratio for a three-dimensional scan of the masses of the $$ {\overset{\sim }{\chi}}_2^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>2</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> , $$ {\overset{\sim }{\chi}}_1^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mover> <mml:mi>χ</mml:mi> <mml:mo>~</mml:mo> </mml:mover> <mml:mn>1</mml:mn> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> and a boson.
Endogenous specialized proresolving mediators enhance antigen-specific antibody response against influenza virus: A new class of adjuvant (P4285) (2013)

Abstract Inflammation is a highly regulated process triggered by the presence of pathogens, injury or trauma. Specialized proresolving mediators (SPMs) are endogenous lipid-derived molecules, which regulate the resolution of inflammation. Resolving inflammation is critical for maintaining homeostasis while assuring immune protection against pathogens, such as influenza virus. We previously showed that the SPM 17-hydroxydosahexaenoic acid (17-HDHA) increased human B cell antibody production in vitro and promoted differentiation towards an antibody-secreting phenotype. Herein, we used a pre-clinical influenza virus immunization mouse model to study the effects of 17-HDHA in vivo. Mice immunized with influenza-derived hemagglutinin (HA) protein plus 17-HDHA have enhanced HA-specific IgM and IgG production compared to mice immunized with HA alone. Enhanced HA-specific antibody production was due to plasma cell increase in the bone marrow. HA-specific antibodies were protective against live influenza viral infection as they decreased morbidity and mortality following viral challenge. Our study shows that DHA-derived SPMs play an important role in enhancing B cell-mediated immunity. An enhanced antigen-specific immune response promotes faster pathogen clearance, and thus return to homeostasis. In addition, these new findings highlight the potential applications of SPMs as new endogenous and non-toxic adjuvants or vaccine "boosters".
The Effect of Age and Refractive Error on Pupil Size (2015)

Purpose: The size of the pupil plays a critical part in controlling the performance of all vision correction modalities incorporating a presbyopic correction, including contact lenses, refractive surgery and intraocular lenses. While the effect of luminance, the dominant factor affecting pupil size, is well known, little information is available regarding other contributing factors such as aging and refractive status. Methods: Three hundred and four patients (127 Male, 177 Female) aged 18 to 78 year made up the cohort population in this study. The non-interventional investigation involved a single visit to the OTG-i clinic. The pupil size was measured at three controlled luminance levels 250cd/m2 (daytime), 50cd/m2 (indoor lighting) and 2.5cd/m2 (night driving). Results: The results obtained showed that: (i) Pupil size decreases with age, the effect being most marked at low luminance. At 250cd/m2 means: 18-39 yrs = 2.8mm, 40-54 yrs = 2.67mm, 55+yrs = 2.56mm (p=0.046). At 50cd/m2 means: 18-39 yrs = 3.68mm, 40-54 yrs = 3.37mm, 55+yrs = 3.21mm (p&lt;0.001). At 2.5cd/m2 means: 18-39 yrs = 6.15mm, 40-54yrs = 5.49mm, 55+yrs = 4.99mm (p&lt;0.001). (ii) Pupil size at low luminance is significantly greater for myopes (high myopes mean = 5.98mm; low myopes mean = 5.91mm) than hyperopes (mean = 5.15mm) (p =0.020). (iii) Pupil size changes modelled by multi linear regression (p&lt;0.001) identified age (p&lt;0.001) and refractive error (p=0.019) as significant factors at low luminance. Conclusions: The study demonstrates that both age and refractive status affect pupil size with larger pupils measured for younger patients and myopes. The implications for the design of multifocal corrections are that the design should take into consideration both the age (faster progression for higher near additions) and refractive power (faster progression for hyperopic corrections).
Device Mismatch: An Analog Design Perspective (2007)

Device variability is receiving a lot of interest recently due to its important impact on the design of digital integrated systems. In analog integrated circuits, the variability of identically designed devices has long been a concern since it directly affects the attainable precision. This paper reviews the mismatch device models that are widely used in analog design as well as the fundamental impact of device mismatch on the trade-off between different performance parameters.
Modeling and performance metrics of MIMO-SDM systems with different amplification schemes in the presence of mode-dependent loss (2015)

Mode-dependent loss (MDL) is a major factor limiting the achievable information rate in multiple-input multiple-output space-division multiplexed systems. In this paper we show that its impact on system performance, which we quantify in terms of the capacity reduction relative to a reference MDL-free system, may depend strongly on the operation of the inline optical amplifiers. This dependency is particularly strong in low mode-count systems. In addition, we discuss ways in which the signal-to-noise ratio of the MDL-free reference system can be defined and quantify the differences in the predicted capacity loss. Finally, we stress the importance of correctly accounting for the effect of MDL on the accumulation of amplification noise.
Cost Analysis of Sofosbuvir/Ribavirin Versus Sofosbuvir/Simeprevir for Genotype 1 Hepatitis C Virus in Interferon-Ineligible/Intolerant Individuals (2014)

These results suggest that a 12-week course of SOF/SMV is a more cost-effective treatment for genotype 1 CHC than 24 weeks of SOF/RBV among IFN-ineligible/intolerant individuals, supporting the AASLD/IDSA guidance and offering implications for both clinical and regulatory decision making as well as pharmaceutical pricing.
A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019) (2019)

<b>Introduction</b>: Histone deacetylase 6 (HDAC6) is unique in comparison with other zinc-dependent HDAC family members. An increasing amount of evidence from clinical and preclinical research demonstrates the potential of HDAC6 inhibition as an effective therapeutic approach for the treatment of cancer, autoimmune diseases, as well as neurological disorders. The recently disclosed crystal structures of HDAC6-ligand complexes offer further means for achieving pharmacophore refinement, thus further accelerating the pace of HDAC6 inhibitor discovery in the last few years.<b>Area covered</b>: This review summarizes the latest clinical status of HDAC6 inhibitors, discusses pharmacological applications of selective HDAC6 inhibitors in neurodegenerative diseases, and describes the patent applications dealing with HDAC6 inhibitors from 2014-2019 that have not been reported in research articles.<b>Expert opinion</b>: Phenylhydroxamate has proven a very useful scaffold in the discovery of potent and selective HDAC6 inhibitors. However, weaknesses of the hydroxamate function such as metabolic instability and mutagenic potential limit its application in the neurological field, where long-term administration is required. The recent invention of oxadiazole-based ligands by pharmaceutical companies may provide a new opportunity to optimize the druglike properties of HDAC6 inhibitors for the treatment of neurodegenerative diseases.
Proceedings of the Agent-Directed Simulation Symposium (2013)

Welcome to the Spring Simulation Multi-Conference 2013 (SpringSim'13) in San Diego, CA. As the General Chair of this year's SpringSim, it is an honor and privilege to be your host for these exciting four days of activities driven and organized by the various members of our society. Despite challenges in the worldwide economy and the overall decrease of funding for travel and conferences, the interest in Modeling and Simulation (M&S) and its applications is still high enough to ensure a challenging and interesting program. From the opening tutorial day where international experts are providing their knowledge to our community to the presentation of peer-reviewed papers, invited special topic presentations, and expert panel discussions the chairs of our symposia did their best to provide an outstanding choice. Without the work of these volunteers, SpringSim would not have been possible.
Identification, expression, and endocrine-disruption of three ecdysone-responsive genes in the sentinel species Gammarus fossarum (2018)

Taking advantage of a large transcriptomic dataset recently obtained in the sentinel crustacean amphipod Gammarus fossarum, we developed an approach based on sequence similarity and phylogenetic reconstruction to identify key players involved in the endocrine regulation of G. fossarum. Our work identified three genes of interest: the nuclear receptors RXR and E75, and the regulator broad-complex (BR). Their involvement in the regulation of molting and reproduction, along with their sensitivity to chemical contamination were experimentally assessed by studying gene expression during the female reproductive cycle, and after laboratory exposure to model endocrine disrupting compounds (EDCs): pyriproxyfen, tebufenozide and piperonyl butoxide. RXR expression suggested a role of this gene in ecdysis and post-molting processes. E75 presented two expression peaks that suggested a role in vitellogenesis, and molting. BR expression showed no variation during molting/reproductive cycle. After exposure to the three EDCs, a strong inhibition of the inter-molt E75 peak was observed with tebufenozide, and an induction of RXR after exposure to pyriproxyfen and piperonyl butoxide. These results confirm the implication of RXR and E75 in hormonal regulation of female reproductive cycles in G. fossarum and their sensitivity towards EDCs opens the possibility of using them as specific endocrine disruption biomarkers.
Deformability-based cell selection with downstream immunofluorescence analysis (2016)

Mechanical properties of single cells have been shown to relate to cell phenotype and malignancy. However, until recently, it has been difficult to directly correlate each cell's biophysical characteristics to its molecular traits. Here, we present a cell sorting technique for use with a suspended microchannel resonator (SMR), which can measure biophysical characteristics of a single cell based on the sensor's record of its buoyant mass as well as its precise position while it traverses through a constricted microfluidic channel. The measurement provides information regarding the amount of time a cell takes to pass through a constriction (passage time), as related to the cell's deformability and surface friction, as well as the particular manner in which it passes through. In the method presented here, cells of interest are determined based on passage time, and are collected off-chip for downstream immunofluorescence imaging. The biophysical single-cell SMR measurement can then be correlated to the molecular expression of the collected cell. This proof-of-principle is demonstrated by sorting and collecting tumor cells from cell line-spiked blood samples as well as a metastatic prostate cancer patient blood sample, identifying them by their surface protein expression and relating them to distinct SMR signal trajectories.
Test and characterisation of modern fast recovery diodes for high speed switching applications (2000)

In modern power electronics applications, diodes and other circuit components have been required to switch at much higher speeds and frequencies. Ultra fast recovery diodes complementing modern high power switching devices such as IGBTs and MOSFETs are available with extremely small switching parameters. Characterisation of such devices requires a good understanding of the device requirements, improved electrical test circuits and special test procedures. In this paper, the main requirements for the test and characterisation of modern ultra fast power diodes are discussed. A brief description of different test circuits traditionally used to carry out the dynamic tests are presented outlining the advantages and disadvantages of each method. In addition, the authors suggests improved methods for testing modern ultra fast diodes especially for high speed switching applications. Results for the diode reverse recovery waveforms obtained using different test circuits are also presented.
A fast turn-around facility for Very Large Scale Integration (VLSI) (1981)

Abstract : In order to appreciate the critical hardware and software problems associated with the definition and design of very large scale integrated circuits or integrated systems including 10 to the 4th power - 10 to the 6th power transistors in a single silicon ship, incisive experiments conducted with actual operating chips are indispensible. The objective of this project is to establish, within a university research environment, a facility for the rapid execution of mask generation, wafer fabrication, and functional testing of user- generated custom I.C. designs.
Task-Based Analog-to-Digital Converters (2021)

Obtaining digital representations of multivariate continuous-time (CT) signals is a challenge encountered in many signal processing systems. In practice, these signals are often acquired to extract some underlying information, i.e., for a specific task. Employing conventional task-agnostic analog-to-digital converters (ADCs), typically designed to minimize the mean squared error (MSE) in reconstructing the CT input signal, can be costly and energy-inefficient in such cases. In this work, we study task-based ADCs, which are designed to obtain a digital representation of a multivariate CT input process with the goal of recovering an underlying statistically related parameter vector, referred to as <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">the task</i> . The proposed system employs analog filtering, uniform sampling, and scalar uniform quantization of the input process before recovering the task vector using a linear digital recovery filter. We optimize the analog and digital filters and derive closed-form expressions for the achievable MSE in recovering the task vector from a set of analog signals when utilizing ADCs with a fixed sampling rate and amplitude resolution. Based on our derivation, we provide guidelines for designing practical acquisition systems subject to a constraint on the bit rate. Our analysis proves that the intuitive approaches of either recovering the task vector solely in digital or designing the analog filter to estimate the task vector are inferior to the proposed joint design. We then consider the recovery of a set of matched filter outputs under a rate budget. We numerically verify our theoretical observations and demonstrate that task-based ADCs substantially outperform analog matched filtering as well as applying the matched filter solely in the digital domain. When acquiring signals for a task under tight bit budgets, we also show that it is often preferable to sample below the Nyquist rate instead of reducing the quantization resolution.
Skeletal Muscle Transection Injury with Tissue Loss (2007)

Despite skeletal muscle’s regenerative capacity, injuries resulting in transection of the fibers and muscle tissue loss can lead to permanent functional loss. Studies with skeletal muscle transection injury‐induced functional loss and recovery generally only use laceration models. Many severe skeletal muscle injuries however, result in the loss of muscle tissue. In order to determine the functional deficit following an injury with tissue loss, a model was developed in which portions of the lateral gastrocnemius (GAS) of Sprague‐Dawley rats were removed. Maximal isometric tetanic tension and twitch tension were measured following the removal of either a 0.5cm × 1.0cm (SDEF) or a 1.0cm × 1.0cm (LDEF) piece of the GAS. The maximal force produced immediately after creation of the defect was 88.3 +/− 2.0% of the non‐operated contralateral GAS force for SDEF and 76.9 +/− 3.2% for LDEF. Fourteen days post‐defect, the maximal force produced was 88.1 +/− 5.6% for SDEF and 80.7 +/− 3.5% for LDEF of the control. Twenty‐eight days post‐defect, the maximal force produced was 80.9 +/− 1.0% for LDEF. These data suggest that little to no functional regeneration occurs in the defected muscle in the first four weeks.
Metamorphic HBT's: InP/InGaAs/InP Devices Grown on GaAs Substrates (2002)

Abstract : This program supported the development of metamorphic heterojunction bipolar transistors (MHBTs). We accomplished this by growing an InP based HBT layer structure on GaAs substrates. InP metamorphic buffer layer was chosen in thermal point of view. Peak values of current-gain cutoff frequency (f(sub t) = 207 GHz) and power-gain cutoff frequency (f(sub max) = 140) were obtained from If devices at bias conditions of V(sub CE) = 1.5 Volts and J(sub c) = 4 x 10(exp 5) A/sq cm. These are the highest values reported for metamorphic HBTs.
Inside Cover: Copper‐Free Click Reactions with Polar Bicyclononyne Derivatives for Modulation of Cellular Imaging (ChemBioChem 10/2014) (2014)

The inside cover picture shows new polar variants of bicyclononyne (BCN) for strain-promoted alkyne–azide cycloaddition. On p. 1446 ff. F. L. van Delft et al. explain how they applied these water-soluble BCN derivatives for glycan labelling of a membrane calcium channel after metabolic incorporation of ManNAz. They found that small changes in BCN hydrophilicity lead to a significant improvement in labelling specificity.
Towards Massive Connectivity Support for Scalable mMTC Communications in\n 5G networks (2018)

The fifth generation of cellular communication systems is foreseen to enable\na multitude of new applications and use cases with very different requirements.\nA new 5G multiservice air interface needs to enhance broadband performance as\nwell as provide new levels of reliability, latency and supported number of\nusers. In this paper we focus on the massive Machine Type Communications (mMTC)\nservice within a multi-service air interface. Specifically, we present an\noverview of different physical and medium access techniques to address the\nproblem of a massive number of access attempts in mMTC and discuss the protocol\nperformance of these solutions in a common evaluation framework.\n
ChemInform Abstract: Iron‐Catalyzed Markovnikov Hydrothiolation of Styrenes. (2012)

Abstract Iron(III) triflimide derived from FeCl 3 and AgNTf 2 is a superior catalyst compared to twenty different metal species and the corresponding Broensted acids.
Correction. New Synthetic Technology for the Construction of Oxocenes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. New Synthetic Technology for the Construction of OxocenesK C. Nicolaou, M E. Duggan, and C-K. HwangCite this: J. Am. Chem. Soc. 1986, 108, 16, 5041Publication Date (Print):August 1, 1986Publication History Published online24 February 2004Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ja00276a607https://doi.org/10.1021/ja00276a607research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analytical Study Based Optimal Placement of Energy Storage Devices in Power Systems to Support Voltage and Angle Stability (2019)

Larger penetration of Distributed Generations ( DG ) in the power system brings new flexibility and opportunity as well as new challenges due to the generally intermittent nature of DG . When these DG are installed in the medium voltage distribution systems as components of the smart grid, further support is required to ensure a smooth and controllable operation. To complement the uncontrollable output power of these resources, energy storage devices need to be incorporated to absorb excessive power and provide power shortage in time of need. They also can provide reactive power to dynamically help the voltage profile. Energy Storage Systems ( ESS ) can be expensive and limited number of them can practically be installed in distribution systems. In addition to frequency regulation and energy time shifting, ESS can support voltage and angle stability in the power network. This paper applies a Jacobian matrix-based sensitivity analysis to determine the most appropriate node in a grid to collectively improve the voltage magnitude and angle of all the nodes by active/reactive power injection. IEEE 14, 24, and 123-bus distribution system are selected to demonstrate the performance of the proposed method. As opposed to most previous studies, this method does not require an iteration loop with a convergence problem nor a network-related complicated objective function.