gebhart/patrepeval huggingface dataset:
Abstract 1473: Dual oncolytic viral immunotherapy generates large polyfunctional tumour-specific CD8 + T cell responses that infiltrate immunosuppressive tumors (2019)

Generating effective T cell mediated clearance of solid tumors remains an unmet challenge in cancer therapy. Suppressive tumor microenvironments limit the generation of significant numbers of tumor specific T effector cells, their migration to tumor beds, and their subsequent functionality within tumors, thereby blocking the patient’s normally potent acquired immune response from contributing to tumor control.In an effort to meet this challenge, we have developed novel oncolytic viruses that were bioselected and engineered to cause cancer cell death through two distinct and complementary mechanisms-of-action, direct cancer lysis and tumor-antigen specific T cell generation. Specifically, we have selected and engineered MG1 Maraba virus which both infects tumor tissue to reverse immune suppressive programs while simultaneously delivering vector encoded tumor antigens to the spleen to vaccinate against the patient’s tumor. The result is a large increase in peripheral and tumor infiltrating CD8+ T effectors cells, strong intratumoral inflammatory signatures and ultimately curative efficacy in preclinical solid tumor models. This first-in-class therapeutic strategy is currently being evaluated in Phase 1 and Phase 2 clinical trials.In this new study, we describe the development of a novel viral immunotherapy platform based on Farmington virus that is: (1) oncolytic in solid tumor models, (2) a potent inducer of highly-functional antigen-specific T cells (expanding tumor specific CD8+ T effector pools over 1000 fold from pre-existing T central memory) and is (3) immunologically distinct from our clinical MG1 Maraba platform. We show that when used sequentially in a heterologous boosting regimen, T cell responses to encoded tumor antigens, either foreign (HPV E7), self (TRP2) or multi-neoantigen, can exceed greater than 50% of all CD8+ T cells in the periphery. The majority of these CD8+ T effectors show markers of polyfunctionality with little expression of the PD-1 exhaustion marker. We will describe our current data assessing the phenotype, localization and potency of these T cell responses in preclinical models of solid tumors and propose strategies to deploy our novel dual oncolytic viral immunotherapy boosting paradigm to the clinic.Citation Format: David Stojdl. Dual oncolytic viral immunotherapy generates large polyfunctional tumour-specific CD8 + T cell responses that infiltrate immunosuppressive tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1473.
Thick cubic GaN grown on GaAs by three-step growth (2002)

Cubic GaN can be grown under some growth conditions, although the crystal structure of the stable phase of GaN is hexagonal. Cubic Ill-nitride materials on GaAs substrates are being developed for use in light emitting devices because of the easy cleavability of this materials and the good conductivity of the substrate. We have reported optically pumped stimulated emission from a cubic GaN/AlGaN heterostructure[l] and a p-n junction diode fabricated from cubic GaN[2]. To improve the crystal quality of epitaxial films, a common method is to increase the growth thickness; however, the film thicknesses reported in these papers were less than 2 pm. This is because the hexagonal phase in cubic GaN tends to increase with increasing growth thickness. In this paper, we report successful growth of thick cubic GaN by a three-step growth process.
Characterization of Porous PLGA/PLA Microparticles as a Scaffold for Three Dimensional Growth of Breast Cancer Cells (2005)

We have designed and evaluated biodegradable porous polymeric microparticles as a scaffold for cell growth. The hypothesis was that microparticles with optimized composition and properties would have better cell adhesion and hence cell growth into a tissue-like structure. Solvent-evaporation method was modified using sucrose as an additive to form large porous microparticles of poly(D,L-lactic-co-glycolic) (PLGA) and polylactide (PLA) polymers. Microparticles containing hydrophilic polymers (poly(vinyl alcohol) and chitosan) incorporated in their internal matrix structure were also formulated. Different formulations of microparticles were evaluated for physical properties, cell adhesion, and cell growth in culture. PLA microparticles containing poly(vinyl alcohol) (PVA) in the matrix structure (PLA-PVA) and treated with serum prior to cell seeding demonstrated better cell adhesion and cell growth than other formulations of microparticles. Cells were seen to grow into clumps, engulfing microparticles completely with time, and forming a 3-D tissue-like structure. Cell density of 1.5 x 10(6) cells per mg of microparticles was achieved in 9 days of culture, which was a 7-fold increase from the initial seeding cell density. The mechanism of better cell growth on PLA-PVA microparticles appears to be due to the PVA associated with the internal matrix structure of microparticles. These microparticles demonstrated better wetting in culture and also cell adhesion. In addition to tissue engineering applications, microparticles with cancer cells grown into a tissue-like structure in vitro can be potentially used as a model system for preclinical evaluation of the cytotoxic effect of anticancer agents.
Reducing the void content and its variability in polymeric fibre reinforced composite test specimens using a vacuum injection moulding process (1990)

To obtain acceptable accuracy and consistency in the mechanical testing of polymeric fibre reinforced composities, it is important that both the fibre alignment and the void content be precisely controlled. In particular, a high void content can greatly affect both the variability and the value of the mechanical strengths of the composite. This paper describes the use of a simple vacuum injection moulding process to produce fibre reinforced composites that have a consistently low void content, of about 1·3%, and a correspondingly high and consistent flexural strength.
Quality Control in the 1990s (1989)

Journal Article Quality Control in the 1990s Get access George S. Cembrowski, MD, PhD, George S. Cembrowski, MD, PhD Nicollet Medical Center and the Department of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis (Dr Cembrowski); Peninsula General Hospital and the Department of Medical Technology, Salisbury State University, Salisbury, MD 21801 (Dr Carey). Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Neill Carey, PhD R. Neill Carey, PhD Nicollet Medical Center and the Department of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis (Dr Cembrowski); Peninsula General Hospital and the Department of Medical Technology, Salisbury State University, Salisbury, MD 21801 (Dr Carey). Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 20, Issue 6, 1 June 1989, Pages 375–376, https://doi.org/10.1093/labmed/20.6.375 Published: 01 June 1989
Multifrequency Excitation of a Clamped-Clamped Microbeam (2015)

We present analytical and experimental investigation of an electrically actuated clamped-clamped microbeam under a two-source harmonic excitation. The first frequency is swept around the first mode of vibration where the second one is fixed. These microbeams are fabricated using polyimide as structural layer coated with nickel form top and chromium and gold layers from bottom. We demonstrate the excitation of additive and subtractive type resonance. We show that by properly tuning the frequency and the amplitude of the excitation force, the frequency bandwidth of the resonator is increased. Theoretically, we solved the eigenvalue problem for different axial forces to find the natural frequencies ratio that match the experimental values. Using Galerkin method, a reduced order model is derived to simulate the static and dynamic response of the device where using three symmetric mode shapes provided a good agreement with experimental data.
ChemInform Abstract: Synthesis of Archaeal Bipolar Lipid Analogues: A Way to Versatile Drug/Gene Delivery Systems. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Methods from Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma (2023)

&lt;p&gt;Supplementary methods including detailed methods on specimen collection and evaluation; DNA and RNA isolation; deep DNA targeted sequencing and transcriptome sequencing; identification and validation of somatic mutations; and expression analysis.&lt;/p&gt;
Dynamic network configuration: Hotspot identification for Virtual Small Cells (2016)

One of the envisaged candidates technologies to be used in next generation mobile networks is the integration of a large number of antennas at the Base Station (BS), known as Massive Multiple-Input Multiple-Output (MIMO). Massive MIMO can focus the energy on a user or group of users to improve their throughput and the network capacity. An approach of this technology focuses on the creation of coverage areas with the size of a pico-cell, called Virtual Small Cells (VSCs). Their main advantage is that they allow increasing the network capacity while avoiding the deployment cost of new small BSs. Identifying the dense traffic areas in real time and serving them in a responsive way is a key challenge to be address. Our work focuses on dynamically identifying the dense traffic areas so that the VSCs can be implemented and adjust their coverage. To conduct this research we use the K-means method and propose an algorithm that dynamically determines the hotspot parameters for VSCs, i.e., center and radius in order to optimize the overall capacity of the mobile network. Note that this algorithm could be used to identify any group of users.
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease (2022)

This new data analytic method demonstrates potential for increasing accuracy of Alzheimer diagnosis.
Electrochemistry of Cu0.5VOPO4·2H2O: A Promising Mixed Metal Phosphorous Oxide for Secondary Lithium based Batteries (2014)

Bimetallic mixed metal vanadium phosphorous oxide structures (MM'PxOy) have been the subject of much recent electrochemistry study. In analogy to silver vanadium phosphorous oxides, this study involves copper vanadium phosphorous oxide. Under galvanostatic discharge in lithium anode cells, the Cu0.5VOPO4·2H2O (CuVPO) material delivered ∼280 mAh/g to 1.5 V. Unlike silver vanadium phosphorous oxides, crystallographic evaluation indicated little structural change upon electrochemical reduction of CuVPO, with no significant change in interlayer spacing and no evidence of copper metal formation. Notably, secondary battery evaluation showed retention of ∼100 mAh/g at C/20 with little fade, a significant improvement under repeated cycling relative to a related silver based material.
Site-Specific Phenylation of Pyridine Catalyzed by Phosphido-Bridged Ruthenium Dimer Complexes:  A Prototype for C−H Arylation of Electron-Deficient Heteroarenes (2005)

Direct and selective catalytic arylation of α-C−H bond in pyridine with iodobenzene was achieved in up to 70% yield. Phosphido-bridged bisruthenium complexes 6a and 6b arising from Ru3(CO)12 and PPh3 were identified as active catalysts. The formation of complexes 6a and 6b was investigated, a sequence of C−H and C−P bond cleavage, cluster fragmentation, and disproportionation was established, and the intermediate ruthenium complexes lying on this pathway were isolated and fully characterized.
Confinement of Charge Carriers and Excitons in Electrophosphorescent Devices: Mechanism of Light Emission and Degradation (2007)

Charge-carrier and exciton confinement is essential for efficiency and stability enhancment of electrophosphorescent devices. Emission-layer lifetimes of a 4,4′-N,N′-dicarbazole-biphenyl host doped with either a red- or green- emitting dye (upper and lower figures) show a strong dependence and near independence, respectively, on the type of exciton blocking layer used (four are shown). This is explained using energy- level differences and corresponding charge-trapping behavior.
Genetic Associations With Gestational Duration and Spontaneous Preterm Birth (2018)

( N Engl J Med . 2017;377(12):1156–1167) Preterm birth is the leading cause of death in neonates and children younger than 5 years of age. Its definition, birth before 37 completed weeks of gestation, is a dichotomous trait based on a somewhat arbitrary cutoff of weeks’ gestation, rather than time of birth or a level of fetal maturity. Therefore, in the present study, the authors tested genetic associations with gestational duration (a quantitative trait) and preterm birth (a dichotomous trait), in order to identify robust associations with genetic variants consistent with a role in the timing of birth.
Terminal Deoxynucleotidyl Transferase in a Case of Childhood Acute Lymphoblastic Leukemia (1973)

Cells from a patient with childhood acute lymphoblastic leukemia contain an apparent DNA polymerase activity that was not found in any other cells except thymus cells. The enzyme has the properties of terminal transferase, an enzyme known to be found in thymocytes. The cells also contain the three major DNA polymerases found in growing cells. The results suggest that these tumor cells arose from a block in the differentiation of thymocytes. Terminal transferase may be a marker for the origin of leukemic cells.
Plasma Polymerized Multi-Layered Photonic Films (2002)

A multilayer optical interference film has been developed using plasma-enhanced chemical vapor deposition (PECVD) of different organic precursor materials. A relatively large refractive index contrast for polymers (>0.2) is achieved by sequential plasma polymerization (PP) of octafluorocyclobutane (OFCB) and benzene. Gas-phase molecules of both precursors, excited by an argon plasma in a flowing afterglow reaction chamber, are deposited on a variety of substrates to form dense, pinhole-free, cross-linked polymer films. The PP-OFCB film yields a refractive index of 1.40, whereas PP-benzene exhibits a refractive index of 1.61 at 500 nm. We report here on the chemical (FTIR and XPS), optical (variable angle spectroscopic ellipsometry and UV−Vis spectrometry), and morphological (scanning electron microscopy) characterization of individually polymerized films of each component. These data are used to design a multilayer film with a notch at ∼1 μm. A ten-bilayer stack (alternating high and low refractive index) was fabricated by sequential deposition of high and low refractive index layers at approximately 1/4λ optical thickness. Optical spectra of the experimental stack exhibit a notch wavelength within several nanometers of the design wavelength indicating good thickness control.
Design and Thermal Analysis of a 3-D Printed Impingement Pin Fin Cold Plate for Heterogeneous Integration Application (2022)

Miniaturization high heat flux of power electronic devices have posed a colossal challenge for adequate thermal management. Conventional air-cooling solutions are inadequate for high-performance electronics. Liquid cooling is an alternative solution due to the higher specific heat and latent heat associated with the coolants. Liquid-cooled cold plates are typically manufactured by different approaches, such as skived, forged, extrusion, and electrical discharge machining. When researchers are facing challenges in creating complex geometries in small spaces, 3-D-printing can be a solution. In this article, a 3-D-printed cold plate was designed and characterized with water coolant. The printed metal fin structures were strong enough to undergo pressure from the fluid flow even at high flow rates and small fin structures. A copper block with the top surface area of 1 in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times \,\,1$ </tex-math></inline-formula> in was used to mimic a computer chip. Experimental data have good match with a simulation model, which was built using commercial software 6SigmaET. Effects of geometry parameters and operating parameters were investigated. The fin diameter was varied from 0.3 to 0.5 mm and the fin height was maintained at 2 mm. A special manifold was designed to maximize the surface contact area between coolant and metal surface and therefore minimize thermal resistance. The flow rate was varied from 0.75 to 2 L/min and the coolant inlet temperature was varied from 25 °C to 48 °C. It was observed that for the coolant inlet temperature 25 °C and aluminum cold plate, the junction temperature was kept below 63.2 °C at an input power of 350 W and the pressure drop did not exceed 23 Kpa. Effects of metal materials used in 3-D-printing on the thermal performance of the cold plate were also studied in detail.
The Factor H Binding Protein of Neisseria meningitidis Interacts with Xenosiderophores in Vitro (2012)

The factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis that confers to the bacterium the ability to resist killing by human serum. The determination of its three-dimensional structure revealed that the carboxyl terminus of the protein folds into an eight-stranded β barrel. The structural similarity of this part of the protein to lipocalins provided the rationale for exploring the ability of fHbp to bind siderophores. We found that fHbp was able to bind in vitro siderophores belonging to the cathecolate family and mapped the interaction site by nuclear magnetic resonance. Our results indicated that the enterobactin binding site was distinct from the site involved in binding to human factor H and stimulates new hypotheses about possible multiple activities of fHbp.
European H2020 Project WORTECS Wireless Mixed Reality Prototyping (2020)

This paper presents European collaborative project WORTECS objectives and reports on the development of several radio and optical wireless prototypes and a demonstrator targeting mixed reality (MR) application. The aim is to achieve a net throughput of up to Tbps in an indoor heterogeneous network for the MR use case, which seems to be a high throughput killer application beyond 5G. A special routing device is associated with the demonstrator to select the most suitable wireless access technology. Post introduction to the project, an overview of the demonstrator is presented with details of the current progress of the prototypes.
Passive Compliance Control of Redundant Serial Manipulators (2018)

Passive compliance control is an approach for controlling the contact forces between a robotic manipulator and a stiff environment. This paper considers passive compliance control using redundant serial manipulators with real-time adjustable joint stiffness. Such manipulators can control the elastic behavior of the end-effector by adjusting the manipulator configuration and by adjusting the intrinsic joint stiffness. The end-effector's time-varying elastic behavior is a beneficial quality for constrained manipulation tasks such as opening doors, turning cranks, and assembling parts. The challenge in passive compliance control is finding suitable joint commands for producing the desired time-varying end-effector position and compliance (task manipulation plan). This problem is addressed by extending the redundant inverse kinematics (RIK) problem to include compliance. This paper presents an effective method for simultaneously attaining the desired end-effector position and end-effector elastic behavior by tracking a desired variation in both the position and the compliance. The set of suitable joint commands is not unique; the method resolves the redundancy by minimizing the actuator velocity norm. The method also compensates for joint deflection due to known external loads, e.g., gravity.
The AT&T spoken language understanding system (2005)

Spoken language understanding (SLU) aims at extracting meaning from natural language speech. Over the past decade, a variety of practical goal-oriented spoken dialog systems have been built for limited domains. SLU in these systems ranges from understanding predetermined phrases through fixed grammars, extracting some predefined named entities, extracting users' intents for call classification, to combinations of users' intents and named entities. In this paper, we present the SLU system of VoiceTone/spl reg/ (a service provided by AT&T where AT&T develops, deploys and hosts spoken dialog applications for enterprise customers). The SLU system includes extracting both intents and the named entities from the users' utterances. For intent determination, we use statistical classifiers trained from labeled data, and for named entity extraction we use rule-based fixed grammars. The focus of our work is to exploit data and to use machine learning techniques to create scalable SLU systems which can be quickly deployed for new domains with minimal human intervention. These objectives are achieved by 1) using the predicate-argument representation of semantic content of an utterance; 2) extending statistical classifiers to seamlessly integrate hand crafted classification rules with the rules learned from data; and 3) developing an active learning framework to minimize the human labeling effort for quickly building the classifier models and adapting them to changes. We present an evaluation of this system using two deployed applications of VoiceTone/spl reg/.
Beyond Multi-Access Edge Computing: Essentials to Realize a Mobile, Constrained Edge (2023)

The main purpose of ETSI multi-access edge computing (MEC) is to improve latency and bandwidth consumption by keeping local traffic local while providing computing resources near the end-user. Despite its clear benefits, the next-generation of hyper-distributed applications (e.g., edge robotics, augmented environments, or smart agriculture) will exacerbate latency and bandwidth requirements, posing significant challenges to today's MEC deployments. In this work, we leverage the current study item ETSI GR MEC 036, introducing a lightweight constrained version of a MEC platform that can be deployed in a mobile end terminal or in its closed locality. This work presents design options for cMEC, and explains how it can untangle the aforementioned problems while being architecturally compatible with a full-fledged MEC framework. Finally, key use cases and still open challenges are discussed, including recommendations to extend the current MEC standard toward constrained environments.