gebhart/patrepeval huggingface dataset:
Identification of Potential Tyrosine-containing Endocytic Motifs in the Carboxyl-tail and Seventh Transmembrane Domain of the Neurokinin 1 Receptor (1997)

Although agonist-induced endocytosis of G-protein-coupled receptors is critical for receptor desensitization and resensitization, receptor motifs that interact with the endocytic apparatus have not been adequately characterized. We examined the effects of mutating the rat neurokinin-1 receptor on endocytosis using 125I-substance P, fluorescent substance P, and receptor antibodies. Substance P induced rapid internalization of wild-type receptors that were targeted to perinuclear endosomes. Truncation of the C-tail at residues 324, 342, and 354 reduced internalization up to 60% and caused retention of receptors at the cell surface and in superficial endosomes. Mutation of Tyr-341 and Tyr-349 in potential tyrosine-containing endocytic motifs of the C-tail also impaired internalization. A Y305A mutant within the putative NPX2-3Y endocytic motif of the seventh transmembrane domain showed impaired signaling and was minimally expressed at the plasma membrane but was found in cytoplasmic vesicles. In contrast, a Y305F mutant signaled normally and was normally expressed at the plasma membrane but showed impaired internalization. Thus, endocytosis of the neurokinin 1 receptor relies on several tyrosine-containing sequences in the C-tail and seventh transmembrane domain.
Enhanced cellular uptake of engineered spider silk particles (2015)

Drug delivery systems allow tissue/cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery. Most drug delivery systems are polymer-based, but the number of possible materials is limited since many commercially available polymers induce allergic or inflammatory responses or lack either biodegradability or the necessary stability in vivo. Spider silk proteins represent a new class of (bio)polymers that can be used as drug depots or drug delivery systems. The recombinant spider silk protein eADF4(C16), which can be processed into different morphologies such as particles, films, or hydrogels, has been shown to fulfil most criteria necessary for its use as biomaterial. Further, eADF4(C16) particles have been shown to be well-suited for drug delivery. Here, a new method was established for particle production to reduce particle size and size distribution. Importantly, cellular uptake of these particles was shown to be poor in HeLa cells. Therefore, variants of eADF4(C16) with inversed net charge or incorporated cell penetrating peptides and receptor interacting motifs were tested, showing much better cellular uptake. Interestingly, uptake of all silk variant particles was mainly achieved by clathrin-mediated endocytosis.
Addressing Health-Care System Inequities in the Management of Erectile Dysfunction: A Call to Action (2020)

Erectile dysfunction (ED) is a common, burdensome, and costly urologic condition strongly related to all aspects of general health, from physical to mental. ED has profound consequences as it may interfere physical well-being, quality of life (QoL), self-esteem, relationships, self-worth, and productivity. It is therefore important to ensure that all types of effective ED treatments are consistently accessible to patients. While federal and state mandates ensure access to treatment for women's breast health, female-factor infertility, and gender affirmation to ensure that these individuals do not experience a diminished QoL, there are no comparable mandates for men's sexual and reproductive health. The burden of ED necessitates a call to action to improve the accessibility of ED treatments. The call to action steps include: (a) coverage for pharmacological, surgical, and other ED treatments should be viewed in the same way as coverage for other health issues, whether male or female and regardless of the stages of treatment, physical dysfunction, or physical changes; (b) American Urological Association (AUA) guidelines for the management of ED should be followed, including implementation of templates in electronic medical records (EMRs) to support adherence to the guidelines; and (c) coverage criteria should explicitly state that the criteria are intended to support gender equity for sexual and reproductive health care and should not be used to prevent men from receiving medically necessary ED treatments. This call to action offers a pathway to support every man who seeks treatment for ED as a medically necessary intervention by removing systemic health-care barriers.
Analog Error-Correcting Codes (2020)

Coding schemes are presented that provide the ability to locate computational errors above a prescribed threshold while using analog resistive devices for approximate real vector-matrix multiplication. In such devices, the matrix is programmed into the device by setting an array of resistors to have conductances proportional to the respective entries in the matrix. In the coding scheme that is considered in this work, redundancy columns are appended so that each row in the programmed matrix forms a codeword of a prescribed linear code C over the real field; the result of the multiplication of any input real row vector by the matrix is then also a codeword of C. While error values within ±δ in the entries of the result are tolerable (for some prescribed δ > 0), outlying errors, with values outside the range ±Δ (for a prescribed Δ ≥ δ) should be located and corrected. As a design and analysis tool for such a setting, a certain functional is defined for the code C, through which a characterization is obtained for the number of outlying errors that can be handled, as a function of the ratio Δ/δ. Several code constructions are then presented, primarily for the case of single outlying error handling. For this case, the coding problem is shown to be related to certain extremal problems on convex polygons.
Web projections (2007)

Graphical relationships among Web pages have been exploited inmethods for ranking search results. To date, specific graphicalproperties have been used in these analyses. We introduce a WebProjection methodology that generalizes prior efforts of graphicalrelationships of the web in several ways. With the approach, wecreate subgraphs by projecting sets of pages and domains onto thelarger web graph, and then use machine learning to constructpredictive models that consider graphical properties as evidence. Wedescribe the method and then present experiments that illustrate theconstruction of predictive models of search result quality and userquery reformulation.
The Novel Deacetylase Inhibitor AR-42 Demonstrates Pre-Clinical Activity in B-Cell Malignancies In Vitro and In Vivo (2010)

Together, these data demonstrate that AR-42 has in vitro and in vivo efficacy at tolerable doses. These results strongly support upcoming phase I testing of AR-42 in B-cell malignancies.
Properties of directional couplers using photonic crystal waveguides (2003)

Coupled photonic crystal waveguides have been designed and modelled with a 3D finite-difference-time-domain method, and fabricated in silicon-on-insulator material. Good agreement between modelled and measured results has been found.
1103-P: Glucose-Responsive Insulin: An Unprecedented Cleavable Linker Concept (2019)

Achieving the optimal combination of multiple glucose measurements and insulin injections provides a complex daily situation for most insulin-dependent diabetes patients with currently available insulin products. To date, several fast-acting and long-acting insulins have been developed. However, while the pharmacokinetic profiles have been optimized, it has remained an elusive goal for decades to develop a Glucose Responsive Insulin (GRI), which can be responsive to the fluctuations in blood glucose concentrations during the day. Here we present an unprecedented GRI concept. The concept is based on the hydrolysis of a cleavable linker that is covalently bound to insulin. The chemical nature of this central linker is designed to rapidly release active insulin when glucose rises above euglycemia (5 mM), and this release of active insulin will increase with increasing blood glucose concentration. The second element of the concept is an albumin-mediated inactivation of the GRI by lipidation. After injection, the GRI will bind to albumin and circulate as a depot, resulting in a slow release of insulin like seen with other basal insulins such as insulin Detemir. At the linker level, we have tested three concentrations of glucose, and glucose responsiveness was demonstrated by a decrease in reaction time with increasing glucose concentration. Moreover, fully conjugated GRI molecules were tested in 90% pancreatectomized rats, a model of type 1 diabetes, demonstrating significant and long-lasting glucose lowering effect as compared to control. Overall, we have demonstrated the feasibility of providing a GRI approach, which combines the properties of a basal insulin with that of a bolus insulin. With the circulating depot approach the concept also holds a promise for liver preference. Ultimately our approach could provide a safe insulin for the treatment of insulin-dependent diabetes with very low risk of side effects. Disclosure K. Mannerstedt: Employee; Self; Gubra. E. Engholm: Employee; Self; Gubra. N.K. Mishra: Employee; Self; Gubra. M. Lundh: Employee; Self; Gubra. N. Buch-Månson: None. L.N. Fink: Employee; Self; Gubra. Stock/Shareholder; Self; Novo Nordisk A/S. S.L. Pedersen: None. P.J. Pedersen: Employee; Self; Gubra. P. Le-Huu: Employee; Self; Gubra, Novo Nordisk A/S. Employee; Spouse/Partner; Novo Nordisk A/S. J. Lai: Employee; Self; Gubra. K.J. Jensen: Consultant; Self; Gubra. Stock/Shareholder; Self; Gubra. K. Fosgerau: Stock/Shareholder; Self; Gubra.
The Unpublicized Sea Change in the Internet (2010)

The Internet is widely (and rightly) recognized as a key enabler of new applications and services. But it's always surprising how much a substantial fraction of the computer science community ignores some of the fundamental changes in the nature of the Internet itself. The Internet's success can largely be credited to the simple yet powerful service abstraction offered by IP networks. The article summarizes some of the important changes the Internet has experienced, focusing primarily on changes below the IP layer. It also highlights how networks participating in the Internet actually interconnect.
Supplementary Figure 5 from Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure 5: Additional details of in vivo study.&lt;/p&gt;
Oral Vaccination with Subunit Vaccines Protects Animals against Aerosol Infection withMycobacterium tuberculosis (2002)

Immunity against Mycobacterium tuberculosis depends largely on activation of cell-mediated responses, and gamma interferon has been shown to play a crucial role in this process in both humans and animal models. Since the lung is normally the organ in which infection is initiated and is the major site of pathology, immune responses in the lung play a significant role in restricting initial infection with M. tuberculosis. The aim of the present study was to stimulate efficient immunity in the lung by targeting the gut mucosa. Detoxified monophosphoryl lipid A (MPL) has been shown to be a relatively nontoxic adjuvant which efficiently promotes the induction of type 1 responses when it is given by the traditional subcutaneous route. We have therefore compared subcutaneous immunization of mice to oral immunization by using a model subunit vaccine carrying two immunodominant proteins from M. tuberculosis, in combination with MPL-based adjuvants. While less effective when used to prime a response, a heterologous priming and boosting vaccination strategy employing oral boosting induced significant systemic type 1 responses which equaled and surpassed those attained by subcutaneous immunization protocols. Moreover, the increased immune responses observed correlated with the induction of substantial protection against subsequent aerosol infection with virulent M. tuberculosis at levels comparable to, or better than, those obtained by multiple subcutaneous vaccinations. These results demonstrate that booster vaccinations via mucosal surfaces, by combining efficient subunit vaccines with the potent adjuvant MPL, may be an effective method of addressing some of the shortcomings of current vaccination strategies.
<title>Improving image application performance of magneto-optic devices utilizing pre-erase</title> (1990)

The read and write transfer rates for large image files are studied as a function of various system parameters and file sizes for a magneto-optic (MO) drive/microcomputer system. In particular, the transfer rate performance of two erase strategies are explored as a function of parameters accessible to the image application developer. Empirical studies have shown that a feature within the magneto-optic (MO) device called pre-erase used in conjunction with the Erase command can increase performance (through-put) by almost a factor of two.
A research project to investigate the impact of electricity system requirements on the design and optimal application of the Powerformer/sup TM/ (2002)

This paper describes the aims and the methodology of a major collaborative research project between the University of Queensland and Australian and Swedish industry partners, including ABB Corporate Research (Sweden), Alstom Power (Sweden and Australia), PowerLink Queensland, Stanwell Corporation, C S Energy and Tarong Energy. The project investigates the likely benefits of significance to the Queensland system, which will arise from the optimisation of the new Powerformer technology for the generation of electricity at transmission or sub-transmission voltages, i.e. without step-up transformers.
Academic Entrepreneurship: The NSF I-Corps Program - Part II [Entrepreneur Viewpoint] (2020)

Reports on the I-Corps program, a nationally-renowned initiative with sites throughout the U.S. One full site was launched at the University of Central Florida (UCF) in January 2015 and was the first I-Corps program in the state of Florida. This program is customer-focused learning and targets early stage startups. It promises that spinning off an invention into a business is a process that can be learned and systematically executed. This program serves as the platform to initiate a conversation between your team members on one side and the market and customer on the other side, test your idea, and provide a better sense of direction for your idea and its applications. It helps students gain the resources, knowledge, confidence, and skills to enter an industry mindset and to convert their creative ideas into something tangible and useful.
Dyes in Liquid Crystals: Experimental and Computational Studies of a Guest–Host System Based on a Combined DFT and MD Approach (2015)

Practical applications of guest-host liquid crystal systems are critically dependent on the alignment of the guest species within the liquid crystal host. UV/Vis absorption spectroscopy shows that the 1,5-dihydroxy-2,6-bis-(4-propylphenyl)-9,10-anthraquinone dye aligns within the E7 nematic host, giving an experimental dichroic ratio of 9.40 and dye order parameter of 0.74. This alignment was modelled by using a combination of density functional theory (DFT) and molecular dynamics (MD) computational approaches that do not require the input of experimental data. Time-dependent DFT calculations show that the electronic transition dipole moment is highly aligned with the long molecular axis of the dye. Fully atomistic MD simulations show that the long axis of the dye is less highly aligned within the E7 host, indicating that this contribution limits the overall dye alignment and, thereby, the potential practical applications of this particular system. Importantly, this study demonstrates an experimental and combined DFT and MD computational approach that may be applied generally to guest-host systems, providing a potential route to their rational design.
High-Performance Composite Bi[sub 2]Ru[sub 2]O[sub 7]–Bi[sub 1.6]Er[sub 0.4]O[sub 3] Cathodes for Intermediate-Temperature Solid Oxide Fuel Cells (2007)

Porous composite electrodes consisting of (BRO7) and (ESB20) were synthesized and characterized using impedance spectroscopy on symmetrical cells. Electrode performance was manipulated compositionally by varying the weight percent of each phase in the composite. Microstructural influences on electrode resistance were examined by varying starting particle sizes of BRO7 and ESB20 powders and using a combination of sedimentation to further reduce particle size and size distributions as well as ultrasonication to break up soft agglomerates. The effect of electrode thickness was also studied by applying successive coats of the electrode inks to the electrolyte substrates. In addition, application of a pure BRO7 current collector was found to dramatically improve performance. Using these optimization techniques, a minimum electrode area specific resistance of was attained at .
Uniform combined reconstruction of multichannel 7T knee MRI receive coil data without the use of a reference scan (2019)

4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:1534-1544.
Graphical models for text (2010)

Almost all text applications use the well known vector-space model for text representation and analysis. While the vector-space model has proven itself to be an effective and efficient representation for mining purposes, it does not preserve information about the ordering of the words in the representation. In this paper, we will introduce the concept of distance graph representations of text data. Such representations preserve distance and ordering information between the words, and provide a much richer representation of the underlying text. This approach enables knowledge discovery from text which is not possible with the use of a pure vector-space representation, because it loses much less information about the ordering of the underlying words. Furthermore, this representation does not require the development of new mining and management techniques. This is because the technique can also be converted into a structural version of the vector-space representation, which allows the use of all existing tools for text. In addition, existing techniques for graph and XML data can be directly leveraged with this new representation. Thus, a much wider spectrum of algorithms is available for processing this representation.
System-level data format exploration for dynamically allocated data structures (2000)

Memory bandwidth and pow er consumption are important design bottlenecks for data dominated applications. We propose a systematic system level exploration approach and formalised techniques to alleviate these bottlenec ks based on rearranging the format of the data records that are later stored in memory. The technique exploits parallelism in the data transfer and reduction in bit waste. Using our approach on sev eral real-life ATM processing applications, significant reduction in size, bandwidth and hence pow er consumption are obtained.
Robust Obstacle Avoidance using Tube NMPC (2018)

This work considers the problem of avoiding obstacles for general nonlinear systems subject to disturbances. Obstacle avoidance is achieved by computing disturbance invariant sets along a nominal trajectory and ensuring these invariant sets do not intersect with obstacles. We develop a novel technique to compute approximate disturbance invariant sets for general nonlinear systems using a set of finite dimensional optimizations. A bi-level NMPC optimization strategy alternates between optimizing over the nominal trajectory and finding the disturbance invariant sets. Simulation results show that the proposed algorithm is able to generate disturbance invariant sets for standard 3D aerial and planar ground vehicles models, and the NMPC algorithm successfully computes obstacle avoidance trajectories using the disturbance invariant sets.
ChemInform Abstract: Studies on Organic Fluorine Compounds. Part 46. Synthesis of 4‐Trifluoromethyl‐2(5H)‐furanone and 4‐Trifluoromethyl‐N‐Substituted Dihydropyrrol‐2‐ones. (1986)

Abstract Ausgehend vom Ester (I) werden, wie im Formclschcma gezeigt.
Demonstration of 28-40-Gbaud, OOK/BPSK/QPSK Data-Transparent Optical Correlation with Control/Tunability over Time Delays, Phases and Number of Taps (2011)

We demonstrate a tunable optical correlator for amplitude and phase modulated signals up to 4-symbol-long patterns using conversion/dispersion based delays. We observed ~1-dB sensitivity penalty (at 10-9 BER) for 2-bit correlation of a BPSK signal. Fine phase control of the taps is shown by wavelength tuning.
Efficient Polymerization of Methyl-ε-Caprolactone Mixtures To Access Sustainable Aliphatic Polyesters (2020)

Aliphatic polyesters are a versatile class of materials that can be sourced from bioderived feedstocks. Poly(γ-methyl-ε-caprolactone) (PγMCL) in particular can be used to make degradable thermoplastic elastomers with outstanding mechanical properties. PγMCL can potentially be manufactured economically from p-cresol, a component of lignin bio-oils. A complication is that additional manufacturing processes are necessary to isolate pure cresol isomers. Using mixed feedstocks of cresol isomers to access the corresponding methyl-substituted ε-caprolactone (MCL) monomer mixtures would convey economic advantages to sourcing these materials sustainably. Moreover, the use of organocatalysts in lieu of traditional tin-based catalysts averts issues with potential environmental and human toxicity. With these motivations in mind, we explored the ring-opening transesterification polymerization (ROTEP) of MCL mixtures and characterized the molecular, thermal, and rheological properties of the resulting copolymers. The molar mass of MCL mixtures that would be obtained from meta- and para-cresol can be readily modulated. The thermal and rheological properties of these statistical copolymers and terpolymers are at parity with pure PγMCL homopolymer. The use of diphenyl phosphate (DPP) and dimethyl phosphate (DMP) as organocatalysts enabled access to these materials that have potential to improve sustainability in the synthesis of these polyesters.
Active-Load Assisted Symbiotic Radio System in Cognitive Radio Network (2020)

In this paper, we consider a spectrum-sharing cognitive radio network (CRN), in which the secondary user (SU) is an active-load assisted symbiotic radio (SR) system. Specifically, the SU transmitter (SU-Tx) exploits multiple antennas to simultaneously support the secondary transmission from the SU-Tx to the SU receiver (SU-Rx) and the backscatter transmission from the active-load assisted backscatter device (BD) to the SU-Rx. As a result, the PU receiver (PU-Rx) is interfered by not only the SU-Tx but also the BD. For such a scenario, the SR system needs to design the transmit beamforming at the SU-Tx and the amplification gain at the BD to balance two conflicting goals, namely, the rate maximization for SU and the interference control to PU-Rx. We formulate an SU rate maximization problem under its own transmit-power constraint, the interference-power constraint as well as some practical constraints introduced by the SR system. This non-convex problem is solved by an alternating optimization based method, which iteratively optimizes the beamforming vector and transmit power at the SU-Tx, and the amplification gain at the BD. Simulation results show that the proposed method outperforms the equal-gain allocation method.
Aldol derivatives of 5-phenyl-1,4-benzodiazepin-2-on-N4-oxide; intriguing inertness of N-oxides in aldol reactions (2003)

In an attempt to prepare 3-substituted 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4benzodiazepin-2-on-N 4 -oxides 7-10, C(3) carbanion of 5-phenyl-1,4-benzodiazepin-2-on-N 4oxide (2) proved completely inert in aldol reaction: Detour to the target compounds 7-10 via aldols 3-6 was required. Unexpected inertness of C(3) carbanion of 2 was attributed to the high charge delocalization.