gebhart/patrepeval huggingface dataset:
Refining amyloid complete hematological response: Quantitative serum free light chains superior to ratio (2020)

Response assessment in light chain (AL) amyloidosis is based on serum and urine monoclonal protein studies. Newly diagnosed patients (n = 373) who achieved very good partial response or complete response (CR) to first line therapy were assessed for the survival impact of each of the monoclonal protein studies. At end of therapy (EOT), negative serum/urine immunofixation (IFE) was achieved in 61% of patients, 72% achieved normal serum free light chain ratio (sFLCR), and the median involved free light chain (iFLC) and difference between involved to uninvolved light chain (dFLC) were 17 mg/L and 5 mg/L, respectively. Overall, 46% of patients achieved a CR at EOT. At EOT, iFLC ≤20 mg/L and dFLC ≤10 mg/L were additive in survival discrimination to negative serum/urine IFE and were independent predictors of overall survival. In contrast, normalization of sFLCR did not add survival discrimination to serum/urine IFE and was not independent predictor of survival. We propose a new definition for hematological CR to include serum/urine IFE negativity plus iFLC ≤20 mg/L or dFLC ≤10 mg/L, instead of the current definition of serum/urine IFE negativity and normal sFLCR. Complete response using dFLC ≤10 mg/L had the best performance in those with significant renal dysfunction and by light chain isotype, making it the preferred partner to IFE. Validation of these results in a multicenter cohort is warranted.
Optical Detection in Microscopic Domains. 1. Monitoring Chemical Manipulations with Absorption Microspectrometry (2000)

In this research, we test whether optical detection techniques, such as absorption microspectrometry, fluorescence detection, and inner filter effects, show different characteristics in microscopic domains (nano-, pico- and femtoliter range) with respect to usual solution volumes. In this part 1, characterization of absorption microspectrometry is facilitated by the use of a novel microscopic tool, the diffusional microburet (DMB), suitable for fine chemical manipulations of microscopic liquid samples. Since diffusional delivery of substances will not induce appreciable changes in volume and shape of the sample, a DMB makes it possible to obtain spectral recordings and a reference spectrum from the same microscopic droplet. Thus, good quantitative spectra of microscopic domains can be assessed. With this approach, despite the curvature of the sample boundaries, the large surface-to-volume ratios, and microscopic optical path lengths, both Beer-Lambert's law and the law of superposition were found to be directly applicable in microscopic domains without any corrections for absorption at sample boundaries. Use of a combination of microspectrometry and chemical manipulations by DMBs made it possible for the first time to record in real time, in truly microscopic domains, spectral evolution upon addition or subtraction of chemicals, as well as monitor the progress of chemical reactions. This approach is expected to contribute to the optical exploration of microchemistry and microanalysis.
Neonatal Hyperglycemia Inhibits Angiogenesis and Induces Inflammation and Neuronal Degeneration in the Retina (2013)

Recent evidence suggests that transient hyperglycemia in extremely low birth weight infants is strongly associated with the occurrence of retinopathy of prematurity (ROP). We propose a new model of Neonatal Hyperglycemia-induced Retinopathy (NHIR) that mimics many aspects of retinopathy of prematurity. Hyperglycemia was induced in newborn rat pups by injection of streptozocine (STZ) at post natal day one (P1). At various time points, animals were assessed for vascular abnormalities, neuronal cell death and accumulation and activation of microglial cells. We here report that streptozotocin induced a rapid and sustained increase of glycemia from P2/3 to P6 without affecting rat pups gain weight or necessitating insulin treatment. Retinal vascular area was significantly reduced in P6 hyperglycemic animals compared to control animals. Hyperglycemia was associated with (i) CCL2 chemokine induction at P6, (ii) a significant recruitment of inflammatory macrophages and an increase in total number of Iba+ macrophages/microglia cells in the inner nuclear layer (INL), and (iii) excessive apoptosis in the INL. NHIR thereby reproduces several aspects of ischemic retinopathies, including ROP and diabetic retinopathies, and might be a useful model to decipher hyperglycemia-induced cellular and molecular mechanisms in the small rodent.
41.5L: Late‐News Paper : Novel Field‐induced Pre‐tilt Alignment Technique Using a Photo‐reactive Alignment Layer for VA LCD (2010)

Abstract We developed a novel LC alignment method for controlling molecular tilt angle by applying a field with photo—reactive polyimide as an alignment layer. This innovative technology establishes a high level VA‐LCD whose characteristic is not only fast response time but also a lower black level even more high reliability.
Al-2.3 Adhesion (2021)

As increasingly smaller molecular materials and material structures are devised or developed for technological applications, the demands on the processes of lithography now routinely include feature sizes that are of the order of 10 nm. In reaching such a fine level of resolution, the methods of lithography have increased markedly in sophistication and brought into play 2terminology that is unfamiliar, on the one hand, to scientists tasked with the development of new lithographic materials or, on the other, to the engineers who design and operate the complex equipment that is required in modern-day processing. Publications produced by scientists need to be understood by engineers and vice versa, and these commonly arise from collaborative research that draws heavily on the terminology of two or more of the traditional disciplines. It is developments in polymer science and material science that lead progress in areas that cross traditional boundaries, such as microlithography. This document provides the exact definitions of a selection of unfamiliar terms that researchers and practitioners from different disciplines might encounter.
Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae (2016)

Streptomyces have a rich history as producers of important natural products and this genus of bacteria has recently garnered attention for its potential applications in the broader context of synthetic biology. However, the dearth of genetic tools available to control and monitor protein production precludes rapid and predictable metabolic engineering that is possible in hosts such as Escherichia coli or Saccharomyces cerevisiae. In an effort to improve genetic tools for Streptomyces venezuelae, we developed a suite of standardized, orthogonal integration vectors and an improved method to monitor protein production in this host. These tools were applied to characterize heterologous promoters and various attB chromosomal integration sites. A final study leveraged the characterized toolset to demonstrate its use in producing the biofuel precursor bisabolene using a chromosomally integrated expression system. These tools advance S. venezuelae to be a practical host for future metabolic engineering efforts.
Design and fabrication of a new system for vibration energy harvesting (2005)

Global simulations, designs and characterisations of a broadband vibration energy scavenging system are here reported. High damping electrostatic conversion structures have been investigated. Mathematical analytical models have been performed and confronted with ANSYS simulations. A scavenging electronics has also been developed: taking in account ohmic, capacitive and inductive losses, the global conversion efficiency has been calculated. Finally, a macro and a micro resonant structure tuned to 50 Hz have been realized. A scavenged power of 1 mW is already available on the macro structure under a vibration amplitude of 90 /spl mu/m at 50 Hz. The corresponding global conversion efficiency is about 60 % which is in good agreement with mechanical and electrical simulations.
Engineering Stark Potentials for Precision Measurements: Optical Lattice Clock and Electrodynamic Surface Trap (2005)

Employing the engineered electric fields, we demonstrate novel platforms for precision measurements with neutral atoms. (1) Applying the light shift cancellation technique, atoms trapped in an optical lattice reveal 50‐Hz‐narrow optical spectrum, yielding nearly an order of magnitude improvement over existing neutral‐atom‐based clocks. (2) Surface Stark trap has been developed to manipulate scalar atoms that are intrinsically robust to decoherence.
Hoch enantioselektive Aza‐Baylis‐Hillman‐Reaktion in einem chiralen Reaktionsmedium (2006)

Let's twist again! Die erste asymmetrische Reaktion wird präsentiert, bei der ein chirales Reaktionsmedium als alleinige Chiralitätsquelle eine hohe Enantioselektivität bewirkt. Aza-Baylis-Hillman-Reaktionen in einer ionischen Flüssigkeit mit chiralem Anion, deren Design auf mechanistischen Erkenntnissen beruhte, ergaben die Produkte mit bis zu 84 % ee.
Effect of the histamine H2-receptor antagonist, cimetidine, on gastric secretion and serum gastrin during insulin infusion in Man. (1976)

&lt;p&gt;The Stack we have means: borderlines are rewritten, dashed, curved, erased, automated; algorithms count as continental divides; the opposition of chthonic versus geometric territory is collapsed by computation; interfaces upon interfaces accumulate into networks, which accumulate into territories, which accumulate into geoscapes (territories comprising territories, made and so entered into, not entered into and so made); the embedded is mobilized and the liquid is tethered down into shelter and infrastructure; the flat, looping planes of jurisdiction multiply and overlap into towered, interwoven stacks; the opaque is transcribed and the transparent is staged, dramatized, and artificialized; irregular allegiances are formalized (the enclave and exclave, for diasporic and satellite expatriates); both futurist and medievalist scenarios con scate, one from another, the program of supercomputational utopias; and the incomplete(able) comprehensiveness of Earth’s archives is folded back on itself as a promiscuous, ambient geopolitics of consumable electrons.&lt;/p&gt;\n
Concurrent array-based queue (2023)

According to one embodiment, a method for implementing an array-based queue in memory of a memory system that includes a controller includes configuring, in the memory, metadata of the array-based queue. The configuring comprises defining, in metadata, an array start location in the memory for the array-based queue, defining, in the metadata, an array size for the array-based queue, defining, in the metadata, a queue top for the array-based queue and defining, in the metadata, a queue bottom for the array-based queue. The method also includes the controller serving a request for an operation on the queue, the request providing the location in the memory of the metadata of the queue.
The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn (2006)

The human 5-HT(6) receptor (5-HT(6)R) is one of the latest cloned receptors among the known 5-HT receptors. Its abundant distribution in the limbic region, which participates in the control of mood and emotion and is involved in nervous system diseases such as depression and Alzheimer disease, has caused it to generate much interest. However, the cellular mechanisms of 5-HT(6)R are poorly understood. In the present study we found, using a yeast two-hybrid assay, that the carboxyl-terminal region of 5-HT(6)R interacts with the Fyn-tyrosine kinase. We also determined using a glutathione S-transferase pulldown assay that this interaction was mediated through the SH3 domain of Fyn and confirmed this by co-immunoprecipitation assays in two different transfected cell lines as well as in adult rat brains. Immunocyto(histo)chemistry also showed prominent co-localization between 5-HT(6)R and Fyn in transfected cells and a similar distribution between 5-HT(6)R and Fyn in the rat brain. Based on this interaction, we further examined the modulation of 5-HT(6)R by Fyn and vice versa. In addition, we demonstrated that the activation of 5-HT(6)R activated the extracellular signal-regulated kinase1/2 via an Fyn-dependent pathway. These findings suggest that Fyn may play an important role in 5-HT(6)R- mediated signaling pathways in the central nervous system.
Error Structure of Impedance Measurements (2008)

This chapter contains sections titled: Error Contributions Stochastic Errors in Impedance Measurements Bias Errors Incorporation of Error Structure Measurement Models for Error Identification Problems
Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-Orthogonal Chemistry and Their Use as Responsive Delivery Systems (2020)

Bio-orthogonal reactions have become an essential tool to prepare biomaterials; for example, in the synthesis of nanocarriers, bio-orthogonal chemistry allows circumventing common obstacles related to the encapsulation of delicate payloads or the occurrence of uncontrolled side reactions, which significantly limit the range of potential payloads to encapsulate. Here, we report a new approach to prepare pH-responsive nanocarriers using dynamic bio-orthogonal chemistry. The reaction between a poly(hydrazide) crosslinker and functionalized polysaccharides was used to form a pH-responsive hydrazone network. The network formation occurred at the interface of aqueous nanodroplets in miniemulsion and led to the production of nanocapsules that were able to encapsulate payloads of different molecular weights. The resulting nanocapsules displayed low cytotoxicity and were able to release the encapsulated payload, in a controlled manner, under mildly acidic conditions.
Publisher Erratum: A study of $$C\!P$$ violation in the decays $${{B} ^\pm } \rightarrow [{{K} ^+} {{K} ^-} {{\uppi } ^+} {{\uppi } ^-} ]_{D} h^{\pm }$$ ($$h = K, \pi $$) and $${{B} ^\pm } \rightarrow [{{\uppi } ^+} {{\uppi } ^-} {{\uppi } ^+} {{\uppi } ^-} ]_{D} h^{\pm }$$ (2023)

In the original article, the PDF version is missing Fig.&amp;nbsp;8. The correct Fig.&amp;nbsp;8 is shown here. (Figure presented.) Interpretation of the binned and phase-space (‘PS’) integrated measurements in terms to the underlying physics parameters. The (Formula presented.) and (Formula presented.) contours are shown, which correspond to (Formula presented.) ((Formula presented.)) and (Formula presented.) ((Formula presented.)) confidence intervals, respectively. Also shown is the result from the analysis of other decay modes at LHCb (‘LHCb 2021’) [21] The original article has been corrected. The publisher apologizes for the inconvenience caused.
Front Matter: Volume 10538 (2018)

This PDF file contains the front matter associated with SPIE Proceedings Volume10538, including the Title Page, Copyright information, Table of Contents, Introduction, and Conference Committee listing.
Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus niveus LU 9575: II. Structure Elucidation (2004)

The structures of new cytochalasan fungal metabolites aspochalamins A-D have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins A-D consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z,13E,19E-triene-1,21-dione.
Modeling the Magneto-Optic Recording Process (1989)

A theoretical model for domain formation in magneto-optic media is presented. Model results are compared to experimental data on a disk with known optical and thermal properties. Application of the model to the magneto-optic data channel is discussed.
Operational Design Domain Monitoring at Runtime for 2D Laser-Based Localization algorithms (2021)

Laser-based localization algorithms are among the key Automated Driving System (ADS) features that enhance the autonomy and safety of Automated Vehicles. These algorithms can provide accurate estimations and are best rated especially in urban environments. The concern of this paper is the integrity of 2D laser-based localization systems, for which we proceed by monitoring their Operational Design Domain (ODD) at runtime. Our approach operates a priori to localization algorithm and is based on laser sensor data only. Our ODD monitoring algorithm uses a local grid-batch to extract features from the laser scans. These features constitute the words that describe the information contained into the sensor data. Then, thanks to machine learning algorithms, the laser scan is classified, either it contains required information for matching, which means the ODD is verified, or the laser scan is not appropriate for matching, in which case we are out of the ODD. This makes our algorithm fit into the bag-of-words paradigm. The validation of our approach is carried out in a very realistic simulation environment where we have the full control over the environment to make labeling as little subjective as possible. Different machine learning algorithms are tested and results are compared and discussed.
CHAPTER 5. The Spinosyn Insecticides (2011)

The spinosyns are unique insecticidal secondary metabolites produced by two soil bacteria, Saccharopolyspora spinosa and S. pogona. Spinosad and spinetoram, the two active ingredients developed from the spinosyns, received Presidential Green Chemistry Challenge Awards in 1999 and 2008, respectively. Spinosad is derived entirely from fermentation, whereas spinetoram is created by making two synthetic modifications to fermentation-derived spinosyn starting materials. These modifications resulted from innovative approaches to quantify spinosyn structure-activity relationships, and the modifications make spinetoram more active and enable it to provide longer-lasting control than spinosad. The spinosyn mode of action involves a unique site on the nicotinic acetylcholine (nACh) receptor. Low toxicity to mammals and most other non-target species provides a wide margin of safety for agricultural workers and the environment. The spinosyns have short environmental persistence and degrade by physical and microbial processes into simpler fragments containing only carbon, oxygen, nitrogen, and hydrogen. Spinosyn insecticide manufacturing is a green, fermentation-based process using renewable agricultural feedstocks. The spinosyn insecticides have had a huge impact on agriculture by providing control of a broad range of important arthropod pests across more than 250 crops in more than 80 countries. Spinosad and spinetoram are generally compatible with Integrated Pest Management (IPM) programs. Spinosad's natural origin has enabled certification for organic agriculture in a growing number of countries, and it has significant noncrop uses in stored grain protection, animal health, and public health. Further research and advances in delivery systems technology will open an even wider range of uses for the spinosyns.
Dose-limiting, adverse event–associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial (2021)

In AF-prone HF patients bradycardia may limit the effectiveness of β blockers, and this property is agent-dependent.
EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB IN ASIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (2017)

In Asian patients with neovascular age-related macular degeneration, functional and morphologic outcomes were largely similar between intravitreal aflibercept and ranibizumab groups, and to results seen in white patients.
Synthesis of 1-aryl-2-amino/anilino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thione and related thioureas (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1-aryl-2-amino/anilino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thione and related thioureasRamesh Chandra and Pramod K. SrivastavaCite this: J. Chem. Eng. Data 1983, 28, 2, 278–279Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/je00032a041https://doi.org/10.1021/je00032a041research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers (2015)

Our findings showed that hsv-encoded hsv1-miR-H18 and hsv2-miR-H9-5p are significantly associated with PCa and can facilitate early diagnosis of PCa for patients within the serum PSA gray zone.
DIPG-62. PRECLINICAL EVALUATION OF IMIPRIDONE-BASED COMBINATION THERAPIES IN PEDIATRIC H3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) (2020)

Abstract Imipridones induce apoptosis in cancer via p53 independent upregulation of TNF-related apoptosis inducing ligand (TRAIL) pathway and its proapoptotic receptor DR5. ONC201, a first-in-class imipridone, is being evaluated alone and with radiotherapy for children with H3K27M mutant diffuse glioma. We sought to determine if ONC201 and its imipridone analogs (ONC206, ONC212) are synergistic with other chemotherapy agents. Seven patient-derived DIPG cell lines, six H3.3K27M mutant (SU-DIPG-IV, SU-DIPG-13, SU-DIPG-25, SU-DIPG-27, SU-DIPG-29, SF8628) and one H3.1K27M mutant (SU-DIPG-36) were grown in culture and exposed to ONC201, ONC206, and ONC212 alone and in combination with histone de-acetylase inhibitors (HDACi) or etoposide. A dose-dependent response to ONC201, ONC206, and ONC212 was demonstrated in all cell lines, with mean IC50 values of 1.46 µM, 0.11 µM, and 0.03 µM respectively. ONC206 and ONC212 induced apoptosis measured by increased expression of cleaved PARP and ISR by increased expression ATF4. In two cell lines, synergy studies revealed combination indices (CI) &amp;lt; 1 for ONC206 and etoposide, with a best CI of 0.62 in SU-DIPG-IV and 0.46 in SU-DIPG-25. Synergy was also observed between ONC201 and etoposide (CI 0.46) and ONC201 and panobinostat (CI 0.01). Imipridones and analogs were superior to panobinostat and etoposide in triggering apoptosis as measured by sub-G1 phase content. Additional synergy and mechanistic analyses are ongoing and will be reported. Our results suggest that H3K27M mutant DIPG cells demonstrate increased sensitivity to imipridone analogs (ONC206 and ONC212) when compared to ONC201. Combinational strategies with etoposide or HDACi should be considered for clinical translation.