gebhart/patrepeval huggingface dataset:
In situ CAD capture (2016)

We present an interactive system to capture CAD-like 3D models of indoor scenes, on a mobile device. To overcome sensory and computational limitations of the mobile platform, we employ an in situ, semi-automated approach and harness the user's high-level knowledge of the scene to assist the reconstruction and modeling algorithms. The modeling proceeds in two stages: (1) The user captures the 3D shape and dimensions of the room. (2) The user then uses voice commands and an augmented reality sketching interface to insert objects of interest, such as furniture, artwork, doors and windows. Our system recognizes the sketches and add a corresponding 3D model into the scene at the appropriate location. The key contributions of this work are the design of a multi-modal user interface to effectively capture the user's semantic understanding of the scene and the underlying algorithms that process the input to produce useful reconstructions.
Role of Isosorbide Comonomer on Interfacial Tension with Subsequent Mophologies & Mechanical Properties of Biobased Poly(L-Lactide)/Poly(Ethylene-co-Isosorbide Terephtalate) Blends (2018)

255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA, MAR 18-22, 2018
Loss of pre-existing tumor-specific T-cells and increase in regulatory T-cells after peptide-vaccination in combination with PADRE, CpG 7909, and Montanide ISA51 (41.42) (2009)

Abstract T-cells with specificity for antigens derived from Wilms-Tumor-gene (WT1), Proteinase3(Pr3), and mucin1(MUC1) have been demonstrated to lyse AML blasts and MM cells and strategies to enhance or induce such tumor-specific T-cells by vaccination are currently explored in multiple clinical trials. To test the safety and immunogenicity of a vaccine composed of WT1-, Pr3-, and MUC1-derived Class I-restricted peptides in combination with CpG 7909 and Montanide ISA51 adjuvants and the PADRE helper epitope, 9 patients with AML or MM were repetitively vaccinated. No clinical responses were observed. Comprehensive immunologic analyses revealed that 5 out of 9 patients harboured non-functional and 2 out of 9 functional MUC1- or WT1-specific CD8+ T-cells prior vaccination. However, neither the pre-existing nor naive de novo WT1-/Pr3-/MUC1-specific CD8+ cells were expanded in vivo by vaccination. Moreover, the pre-existing WT1-/MUC1-specific T-cells became no longer detected following vaccination, whereas the frequency and function of CMV-specific CD8+ T-cells was unchanged. A more than 2-fold increase in PADRE-specific CD4+ T-helper-cells was observed but these did not produce IL2, and CD4+ T-cells with a regulatory phenotype increased more than 2-fold. These results are in stark contrast to previous vaccination studies, and should be carefully taken into consideration in the context of multiple ongoing as well as future clinical vaccination trials.
Temperature-dependent optical measurements of the dominant recombination mechanisms in InAs/InAsSb type-2 superlattices (2015)

Temperature-dependent measurements of carrier recombination rates using a time-resolved optical pump-probe technique are reported for mid-wave infrared InAs/InAs1−xSbx type-2 superlattices (T2SLs). By engineering the layer widths and alloy compositions, a 16 K band-gap of ∼235 ± 10 meV was achieved for five unintentionally and four intentionally doped T2SLs. Carrier lifetimes were determined by fitting lifetime models based on Shockley-Read-Hall (SRH), radiative, and Auger recombination processes to the temperature and excess carrier density dependent data. The minority carrier (MC), radiative, and Auger lifetimes were observed to generally increase with increasing antimony content and decreasing layer thickness for the unintentionally doped T2SLs. The MC lifetime is limited by SRH processes at temperatures below 200 K in the unintentionally doped T2SLs. The extracted SRH defect energy levels were found to be near mid-bandgap. Also, it is observed that the MC lifetime is limited by Auger recombination in the intentionally doped T2SLs with doping levels greater than n ∼ 1016 cm−3.
Effect of Perfusion Culture on Localization, Intensity, and Functionality of Transporter Proteins in a Bilayer Proximal Tubule-on-a Chip (2021)

A biomimetic proximal tubule on-a-chip (PToC) comprised of isolated endothelial and epithelial microchannels along with a custom-made culture media perfusion system is presented. The microfluidic setup enables independently-addressable perfusion of epithelial and endothelial culture media for optimum bilayer health and function. It was shown for the first time that flow-induced shear stress not only enhances the expression level of megalin, a major proximal tubule transmembrane protein involved in albumin transcytosis, but also increases the chance of its presence/activity in the cytosol milieu. Albumin reabsorption capacity of the bilayer was improved through the epithelium subjected to shear stress, the cell height was increased, and the apical microvilli were fortified.
Ethylene/Norbornene Copolymerizations with Titanium CpA Catalysts (1999)

Group 4 ansa-cyclopentadienylamido (CpA) complexes [Me2Si(Cp‘)(NR)]MCl2 (R = alkyl, M = Ti, Zr) efficiently copolymerize ethylene with a variety of α-olefins. Ethylene/norbornene copolymerization reactivity ratios were determined at 40 °C for CpA catalysts [Me2Si(Cp‘)(NtBu)]TiCl2 (Cp‘ = Me4Cp, 2,4-Me2Cp, 3-tBuCp, Ind), and the resulting values are low (r1 = 2.0−5.1, r2 → 0), suggesting a tendency toward alternating comonomer insertion at high norbornene/ethylene feed ratios. As reaction temperature is increased and norbornene concentration is decreased, productivity increases and norbornene incorporation decreases. No more than 46 mol % norbornene is incorporated into the copolymer using these CpA catalysts even at low feed ratios (E/N ≥ 0.02), and norbornene homopolymerizations with [Me2Si(Me4Cp)(NtBu)]TiCl2 proceed to very low conversion (<1%). 13C NMR spectroscopy of CpA-derived poly(ethylene-co-norbornene)s shows the copolymers contain virtually no consecutive norbornene sequences, and the microstructure of the resulting ethylene norbornene copolymers is dependent on catalyst geometry.
Preparation of .alpha.,.beta.-unsaturated carboxylic acids and esters (2023)

Disclosed is a process for the preparation of .alpha.,.beta.-unsaturated carboxylic acids and esters thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic acid, ester or anhydride in the presence of a catalyst comprising an oxide of niobium.
STEROIDS: I. 12β-METHYL-12α-HYDROXYPROGESTERONE (1961)

Lithium aluminum hydride reduction of 3α,12α -diacetoxypregnan-20-one (Ia) gives as the major product pregnane-3α,12α,20β-triol (III), whereas the reduction of the corresponding dihydroxypregnanone I affords mainly the epimeric 3α,12α,20α-triol II. Triol III was transformed to 12β-methyl-12α-hydroxyprogesterone (VIII).
Enabling Biomedical Research in Europe: Using the Dutch Experience as a Template (2007)

Medical centers in the Netherlands contain a wealth of patient information that could be leveraged by healthcare researchers to drive breakthroughs, to deliver innovation in healthcare and improve the quality of life for Dutch citizens. However, the sensitivity of this data, the fragmentation of patient records and the complexity of retrieving this information have inhibited advances in this arena. In order to open up clinical data to researchers, the Academic Medical Center (AMC) in Amsterdam has implemented a framework that addresses the problems outlined, mitigates the risk for practitioners and patients and enables medical innovation to proceed. In this paper, we describe the AMC environment, we present the system implemented and highlight the benefits of employing this technological approach. We purport that the AMC model can be used as a template for Biobanks across the world.
Cancellation of Doppler intrinsic spectral broadening using ultrafast Doppler imaging (2014)

Although conventional pulse-wave Doppler has proved to be a valuable diagnostic method for many vascular pathologies, it is hampered by issues related to repeatability as well as problems associated with quantification and system-dependent variability. These limitations are due to intrinsic spectral broadening on the Doppler spectrum, resulting from the directivity pattern of the ultrasound focused beam. Here, we develop a new spatial statistical technique, Doppler frequency spatial analysis (DFSA), which is based on ultrafast plane-wave imaging. Similar to standard pulse-wave Doppler, which is commonly used by sonographers, it yields a two-dimensional output (frequency versus time), while dramatically reducing the presence of intrinsic spectral broadening on the Doppler spectra. Therefore, the technique is much more sensitive to the velocity profile and turbulences than the standard pulse-wave Doppler. The proposed technique could improve diagnosis of vascular diseases, including arterial plaque characterization. Moreover, by summarizing all main information contained in the ultrafast Doppler acquisition, it permits a direct visualization of the data within the velocity profile. Here, we have compared our novel statistical technique to the standard pulse-wave Doppler approach during in vivo imaging of the human carotid artery. Notably, we achieved a greater than 4-fold reduction in intrinsic spectral broadening.
Large Scale Purification of Heparinase (1987)

Abstract Isoelectric points of the glycosaminoglycan‐degrading enzymes in Flavobacterium heparinum were determined by a recently developed method, the pH‐dependent binding analysis. Based upon these data, we developed a facile method that was conducive to producing gram quantities of heparinase that was nearly free from the other enzymes. The method includes a combination of batch procedures of hydroxylapatite and QAE‐Sephadex chromatography. The resulting heparinase preparation contains less than 1% of each of the above enzymes, except for heparitinase, which is present at a maximum level of about 3%. It also shows identical kinetic properties to those of a completely purified heparinase. The strategy described in this paper may be useful in developing other large‐scale protein purification methods.
Plan of Township No. 32: compiled from the proprietors plans and Meacham's Atlas and from the descriptions in leases and registered deeds with additions and corrections from various surveys made previous to the year 1918 by Thomas W. May L. S. January 1919 (1917)

The map shows Lot 57 divided into parcels of land with names of residents, acreage amounts and land conveyance references. Areas drawn in black indicate land conveyed to the government and re-conveyed to leaseholders or purchasers; areas in red indicate land that became freehold under the proprietor or land not sold to the government. The map shows the Murray Harbour Railway in red and shows roads in black or brown. Bodies of water, which include Orwell Bay and Orwell River, are coloured or outlined blue. Dams on rivers are shown. Sandy areas are shown with stippling. Compass rose with north and magnetic north arrows with variation for 1764.
Introduction of Perylene Units for Enhanced Interchain Interaction in Conjugated Polymers for Organic Photovoltaic Devices (2012)

A series of semiconducting copolymers, poly[2,7-(9,9′-dioctylfluorene)-alt-5,5′-(4′,7′-di-2-thienyl-2′,1′,3′-benzothiadiazole)] (PFDTBT), poly[2,2′-(9,9-dioctyl-9H-fluorene-2,7-diyl)dithiophene-alt-5,5′-(4′,7′-di-2-thienyl-2′,1′,3′-benzothiadiazole)] (PFD2TBT), and their ter-polymers containing perylene units were synthesized using Suzuki coupling polymerization. The perylene units were introduced to improve the charge-transport ability by enhancing the π–π interaction between polymer chains. The resulting polymers were characterized by 1H NMR, elemental analysis, DSC, and TGA. The synthesized polymers were soluble in common organic solvents, and formed smooth and uniform spin-coated thin films. All of the polymers studied were found to exhibit good thermal stability, losing less than 5% of their weight upon heating to approximately 350 °C. Perylene- containing polymers showed higher field-effect mobilities than the corresponding PFDTBT or PFD2TBT polymers because of the enhanced π–π interaction between polymer chains upon the introduction of perylene units. Bulk heterojunction solar cells were fabricated with configuration of ITO/PEDOT:PSS/polymer:PC71BM/TiOx/Al. The devices using the perylene-containing polymers showed higher short-circuit currents, and fill factors than the corresponding PFDTBT or PFD2TBT devices. One of the fabricated devices using a perylene-containing copolymer showed a maximum power conversion efficiency of 3.16%, with a short circuit current density of 9.61 mA/cm2, open circuit voltage of 0.81 V, and fill factor of 41%.
Fluid fibres in true 3D ferroelectric liquids (2023)

We demonstrate an exceptional ability of a high-polarisation 3D ferroelectric liquid to form freely-suspended fluid fibres at room temperature. Unlike fluid threads in modulated smectics and columnar phases, where translational order is a prerequisite for forming liquid fibres, recently discovered ferroelectric nematic forms fibres with solely orientational molecular order. Additional stabilisation mechanisms based on the polar nature of the mesophase are required for this. We propose a model for such a mechanism and show that these fibres demonstrate an exceptional non-linear optical response and exhibit electric field-driven instabilities.
Role of Phosphoinositide 3‐kinase in induction and maintenance of B cell self tolerance (2008)

Phosphoinositide 3‐kinase (PI3K) plays important roles in BCR‐dependent signal transduction, therefore it is critical in B cell development and activation. B cell tolerance to self antigen is induced and maintained mainly by clonal deletion and peripheral anergy. To assess the function of PI3K in the regulation of B cell self tolerance, mice lacking the gene for p85α (p85α−/−), the most important regulatory subunit of the class IA PI3Ks, were bred with anti‐hen egg lysozyme (HEL) immunoglobulin (HEL‐Ig) and membrane HEL (mHEL) or soluble HEL (sHEL). We found that development of monoclonal anti‐HEL‐Ig B cells was severely impaired in p85α−/− HEL‐Ig mice. Massive deletion of HEL‐specific B cells were observed in HEL‐Ig/mHEL double‐transgenic mice, even in the absence of p85α. Furthermore, anergy induction in HEL‐Ig/sHEL mice, represented by reduced production of anti‐HEL IgM antibody and impaired proliferative responses of B cells was maintained in p85α−/− double‐transgenic (HEL‐Ig/sHEL) mice. These results suggest that PI3K is essential for B cell maturation but not required for clonal deletion and anergy induction of self‐reactive clones.
A Porous Silicon−Palladium Composite Film for Optical Interferometric Sensing of Hydrogen (2004)

Porous Si Fabry-Pérot films are coated with Pd via immersion plating. The materials are characterized by electron microscopy and infrared spectroscopy. The Pd-coated porous Si samples exhibit distinct Fabry-Pérot fringes in the optical reflection spectrum due to thin film optical interference in the porous Si layer, though the reflectivity spectrum loses fidelity upon Pd coating. The effect of H2 exposure on the interference spectrum is studied. Absorption of hydrogen into Pd induces a lattice expansion, which results in a shift of the optical fringes and a decrease in the reflected intensity. The detection limit measured at room temperature is approximately 0.2% (by volume) in an N2 carrier gas, with a response time of a few seconds.
Neue Cu-Komplexe für die effiziente Herstellung von F-18-markierten Aromaten (2023)

Ziel/Aim Die Cu-vermittelte Radiofluorierung ist ein vielseitiges Verfahren zur Herstellung radiofluorierter (Hetero)aromaten. Ziel dieser Arbeit war die Herstellung und Evaluierung neuer Cu-Mediatoren. Zusätzlich sollten die Reaktionsbedingungen der Cu-vermittelten Radiofluorierung optimiert und die praktische Anwendbarkeit des neuen Protokolls durch die Synthese verschiedener PET-Tracer (Vorläufermenge:≤10 µmol) bestätigt werden.
Synthesis of Oligoarylenevinylenes with Fluorinated Double Bonds (2008)

Oligoarylenevinylenes with fluorine atoms in the vinylene&#13;\nunits and side-chains with a range of polarities bonded to the&#13;\naryl rings, have been synthesized via a methodology based on the&#13;\nStille cross-coupling reaction. All compounds were stereoselectively&#13;\nsynthesized with trans double bonds.
Abstract MP57: Associations of Pentraxin 3 with Frailty: The Cardiovascular Health Study (CHS) (2016)

Background: Pentraxin 3 (PTX3) is an inflammatory biomarker primarily reflecting vascular damage. PTX3 is associated with cardiovascular disease (CVD); however, associations with frailty, another inflammation-related disease of aging, are unknown. Methods: At baseline, we examined these associations in 1,948 white and black men and women (mean age 73 y) in the Cardiovascular Health Study (CHS) who had measures of PTX3 and were free of dementia, Parkinson’s disease and depression. PTX3 was determined by immunoassay (coefficient of variation 10%). Robust regression models were minimally adjusted for age, sex, ethnicity and clinic site with additional adjustments for obesity, smoking, education, C-reactive protein (CRP) and prevalent subclinical or clinical CVD. Results: Levels of PTX3 ranged from 0.24 - 23.05 ng/ml, mean 2.36 ng/ml (standard deviation 2.00 ng/ml), in these older adults. PTX3 was significantly associated with unintentional weight loss (p&lt;0.001), slow walk time (p=0.04) and low grip strength (p=0.03), but not the other domains of frailty, exhaustion and physical activity, both p&gt;0.2. Increased PTX3 was also associated with frailty status comparing those who were not frail (0 domains of frailty, N=879) to those who were intermediate frail (presence of 1-2 domains of frailty, N=926) or frail (≥3 domains, N=143). In minimally adjusted models, the relative risk (RR) for intermediate frailty was 1.22 (95% confidence interval 1.04-1.44) and 1.70 (1.25-2.29) for prevalent frailty, comparing both to non-frail. Results were slightly attenuated but remained significant in fully adjusted models; RR 1.19 (1.01-1.41) for intermediate and 1.59 (1.16-2.18) for frail. As some biomarkers show sex-dependent associations, we stratified on sex. In fully adjusted models, increased PTX3 was associated with intermediate frailty (RR 1.3; 1.00-1.69) and frailty (RR 2.14; 1.24-3.67) in men, but did not appear to be associated in women (RR 1.13; 0.91-1.42 for intermediate and 1.28; 0.85-1.92 for frail); however, the interaction term was not significant (p=0.2). Conclusions: In these older adults, PTX3 was associated with some domains of frailty and frailty status. Associations were independent of the presence of clinical and/or subclinical CVD and CRP, a biomarker of general inflammation. PTX3 may reflect ongoing vascular damage in multiple aging-related diseases such as CVD and frailty. Further study is needed to evaluate the potential for PTX3 to act as a biomarker of healthy aging.
Laser-driven electron acceleration in plasmas with few-cycle pulses (2009)

We report on laser-driven electron acceleration with 8 fs, i.e. three optical cycles, pulse duration and 40 mJ energy. Theory and numerical simulations predict that this experimentally unexplored parameter range is relevant for laser wake-field acceleration. The electron spectra produced are monoenergetic with a peak up to 50 MeV and free of low-energy electrons with thermal spectrum. The electron beam has a typical divergence of 5–10 mrad. The accelerator is routinely operated at 10 Hz and correspondingly it is a promising source for several applications.
ChemInform Abstract: CYCLISCHE SULFONE DER BENZOXATHIIN‐1,4‐REIHE (1971)

Abstract Die Sulfinsäure (I) reagiert mit α‐Bromketonen (II) in Gegenwart von Natriummethylat zu den Ketosulfonen (III).
Investigation of Steady-State Cornering Characteristics of Motorcycles Based on Tire Slip Angle Measurement (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In this study, the results of a steady-state cornering test using a sport-touring motorcycle and the analysis of those test results are presented. This test was conducted as one activity in our efforts to realize a quantitative development method for motorcycles. The measurement data from this test include measurement results for tire force, tire moment, and tire slip angle that have not been practically addressed in the research of motorcycles, in addition to normal measurement results for velocity, steering angle, steering torque, roll angle, and the like.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt; Up to now research on motorcycle dynamics characteristics has indicated that “there is a strong relationship between the motorcycle dynamics characteristics and the tire slip angle”. However, since it is difficult to take highly precise measurements of the motorcycle's tire slip angle during actual riding, especially when the motorcycle is tilted during cornering, such measurements have been avoided.[ &lt;span class="xref"&gt;1&lt;/span&gt; ] Nevertheless, in this research we attempted to measure the tire slip angle and also attempted to investigate in detail the dynamics characteristics and tire characteristics during riding. Up to this point there has not been an adequate investigation conducted under a variety of riding conditions, but it is the aim of this research to show that it is possible to measure the tire slip angle with good accuracy. It is our opinion that this will open a new path to a more detailed investigation of the motorcycle's dynamics characteristics. &lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In addition, we conducted measurements using not only the normal rider's lean angle (lean-with posture), but also measurements in the case where the rider's lean angle was intentionally changed, in order to investigate the effects that a change in the rider's posture has on the variation in the measurement results of the motorcycle's dynamics. Furthermore, we then compared these measurement results to the results obtained from simulations. Additionally, steering index values were calculated from the measurement results. These calculated index values include the stability factors, slip angle factors, and steering torque factors.&lt;/div&gt;&lt;/div&gt;