gebhart/patrepeval huggingface dataset:
High-Throughput Molecular Imaging for the Identification of FADD Kinase Inhibitors (2010)

Fas-associated protein with death domain (FADD) was originally reported as a proapoptotic adaptor molecule that mediates receptor-induced apoptosis. Recent studies have revealed a potential role of FADD in NF-κB activation, embryogenesis, and cell cycle regulation and proliferation. Overexpression of FADD and its phosphorylation have been associated with the transformed phenotype in many cancers and is therefore a potential target for therapeutic intervention. In an effort to delineate signaling events that lead to FADD phosphorylation and to identify novel compounds that impinge on this pathway, the authors developed a cell-based reporter for FADD kinase activity. The reporter assay, optimized for a high-throughput screen (HTS), measures bioluminescence in response to modulation of FADD kinase activity in live cells. In addition, the potential use of the reporter cell line in the rapid evaluation of pharmacologic properties of HTS hits in mouse models has been demonstrated.
Neutron Background Detection for a Hard X-ray Balloon-borne Polarimeter (2015)

PoGOLite is a balloon-borne hard X-ray polarimeter. It determines polarisation by measuring the azimuthal angular distribution of Compton scattered photons in a plastic scintillator array. The use of an all-plastic target yields a relatively large, low-mass detection area. The dominant source of background for these measurements has been shown, through Geant4 simulations, to originate from high energy (MeV range) atmospheric neutrons. Neutrons can pass the instrument's Bismuth Germanium Oxide (BGO) anti-coincidence shield undetected and subsequently scatter between plastic scintillator elements to produce a polarisation signature. A passive 15 cm thick polyethylene shield surrounding the polarimeter reduces the neutron induced background by an order of magnitude. The background level remains however significant, prompting the need for active monitoring of the continuously changing neutron flux. For this purpose PoGOLite makes use of a phoswich scintillator cell. The phoswich cell consists of a 5 mm thick Lithium Calcium Aluminium Fluoride (LiCAF) scintillator, used for neutron detection. The LiCAF is surrounded by a BGO anti-coincidence system. This small light weight detector can therefore be used to measure the neutron flux even in high radiation environments. This type of neutron detector was tested on a separate dedicated stratospheric balloon mission in March 2013, called PoGOLino, prior to the PoGOLite flight which took place in July 2013. Results from the test flight and implications for the measurements performed on the PoGOLite flight will be discussed.
Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids (2019)

&lt;div&gt; &lt;div&gt; &lt;div&gt; &lt;p&gt;The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. &lt;/p&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;
Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice (2020)

Intestinal alkaline phosphatase (IAP) is an endogenous enzyme that promotes gastrointestinal homeostasis by detoxifying inflammatory mediators, tightening the gut barrier and promoting a healthy microbiome. Oral IAP administration was efficacious in ameliorating diabetes in a high fat diet (HFD)-induced murine model. In humans, maternal obesity and diabetes during pregnancy have been associated with an increased risk of autism spectrum disorders (ASD). In mice, HFD-induced maternal obesity leads to offspring with cognitive deficiency. Here we investigated whether IAP administration to obese dams could ameliorate autism-like disorders in mice. Using a HFD murine model, we recapitulated that maternal obesity leads to male offspring with social deficits as shown by the three chamber test and reciprocal social interaction analyses. Notably, oral delivery of IAP to dams improved those deficiencies. In addition, a jumping behavior was noted in pups from obese dams, which was rescued by maternal IAP treatment. Our findings suggest that maternal treatment with IAP can relieve some ASD-like symptoms in offspring mice.
2.8 A broadband CMOS digital power amplifier with hybrid Class-G Doherty efficiency enhancement (2015)

Spectrum-efficient modulations in modern wireless systems often result in large peak-to-average power ratios (PAPRs) for the transmitted signals. Therefore, PA efficiency at deep power back-off (PBO) levels (e.g., -12dB) becomes critical to extend the mobile's battery life. Classic techniques, i.e., outphasing, envelope tracking, and Doherty PAs, offer marginal efficiency improvement at deep PBO in practice. Dual-mode PAs require switches at the PA output for high-/low-power mode selection [1,2], posing reliability and linearity challenges. Although simple supply switching (Class-G) is effective at deep PBO, it only offers Class-B-like PBO efficiency in each supply mode [3,4]. Multi-level outphasing PA requires multiple supplies and frequent supply switching [5], resulting in substantial DC-DC converter overhead and exacerbated switching noise.
<title>Figures of merit of nonlinear optical chromophores in photorefractive polymers</title> (1999)

A pre-requisite to obtain polymers with a large photorefractive response is to design non-linear optical chromophores with a large figure of merit. This figure depends on the glass transition temperature of the material. We present a theoretical investigation that shows which are the important molecular parameters that control the magnitude of the figure of merit either in a low-Tg or in a high-Tg polymer. Derivation of the figures of merit for various push-pull molecules show a molecular engineering strategy can be successfully implemented to yield very large figures of merit. This approach is supported by an experimental investigation based on electro-optical absorption measurements.© (1999) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates (2008)

Recombinant human parainfluenza virus type 1 (rHPIV1) was modified to create rHPIV1-P(C-), a virus in which expression of the C proteins (C', C, Y1, and Y2) was silenced without affecting the amino acid sequence of the P protein. Infectious rHPIV1-P(C-) was readily recovered from cDNA, indicating that the four C proteins were not essential for virus replication. Early during infection in vitro, rHPIV1-P(C-) replicated as efficiently as wild-type (wt) HPIV1, but its titer subsequently decreased coincident with the onset of an extensive cytopathic effect not observed with wt rHPIV1. rHPIV1-P(C-) infection, but not wt rHPIV1 infection, induced caspase 3 activation and nuclear fragmentation in LLC-MK2 cells, identifying the HPIV1 C proteins as inhibitors of apoptosis. In contrast to wt rHPIV1, rHPIV1-P(C-) and rHPIV1-C(F170S), a mutant encoding an F170S substitution in C, induced interferon (IFN) and did not inhibit IFN signaling in vitro. However, only rHPIV1-P(C-) induced apoptosis. Thus, the anti-IFN and antiapoptosis activities of HPIV1 were separable: both activities are disabled in rHPIV1-P(C-), whereas only the anti-IFN activity is disabled in rHPIV1-C(F170S). In African green monkeys (AGMs), rHPIV1-P(C-) was considerably more attenuated than rHPIV1-C(F170S), suggesting that disabling the anti-IFN and antiapoptotic activities of HPIV1 had additive effects on attenuation in vivo. Although rHPIV1-P(C-) protected against challenge with wt HPIV1, its highly restricted replication in AGMs and in primary human airway epithelial cell cultures suggests that it might be overattenuated for use as a vaccine. Thus, the C proteins of HPIV1 are nonessential but have anti-IFN and antiapoptosis activities required for virulence in primates.
A Ka-band digitally-controlled phase shifter with sub-degree phase precision (2016)

We present a passive digital-to-phase converter with sub-degree phase precision for phased array frontends. The phase tuning approach is based on manipulating the electromagnetic properties of an artificially constructed transmission line. By simultaneously controlling dispersion, characteristic impedance, and loss across the structure, the phase shifter minimizes phase imprecisions while ensuring a flat amplitude response across different phase settings. The chip prototype is fabricated in a 130nm SiGe BiCMOS process, occupies an area of 0.18mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and consumes no power. The insertion loss is -9.3 dB ± 0.25 dB at 28 GHz. The phase control operates with 4.75 degree steps while maintaining an RMS phase error of 0.6 degrees across multiple chips and temperatures, demonstrating the best phase and amplitude accuracy when compared to state-of-the-art integrated microwave and mm-wave phase shifters.
Mangostanaxanthone VIIII, a new xanthone from Garcinia mangostana pericarps, α-amylase inhibitory activity, and molecular docking studies (2019)

A new xanthone: mangostanaxanthone VIIII [1,3,5,6,7-pentahydroxy-2-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbut-1-enyl) xanthone] (5) and four known xanthones: mangostanaxanthones I (1) and II (2), γ-mangostin (3), and mangostanaxanthone VII (4) were separated and characterized from the acetone fraction of Garcinia mangostana L., Clusiaceae (mangosteen) pericarps. Their structures were established based on various spectroscopic analyses in addition to HRMS and comparison with the literature. The α-amylase inhibitory potential of the isolated metabolites was evaluated. Compounds 1, 2, and 5 had the highest activity with % inhibition 72.5, 86.5, and 81.8, respectively compared to acarbose (97.1%, reference α-amylase inhibitor). The molecular docking study of the tested metabolites was estimated to shade up the rational explanation of the α-amylase inhibitory activity results. Moreover, the pharmacokinetic parameters were assessed using Swiss ADME. It is noteworthy that 1, 2, and 5 had similar binding poses as the X-ray crystal structure of acarbose, whereas the other metabolites possessed different binding mode that decreased their inhibitory capacity. Thus, these data reinforced the health benefit of mangosteen as an alternative medicine to help lowering the postprandial glucose absorption. Therefore, it could have a good potential for the treatment of diabetes.
Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies (2008)

The heterogeneity of symptoms and disease progression observed in synucleinopathies, of which Parkinson's disease (PD) is the most common representative, poses large problems for the discovery of novel therapeutics. The molecular basis for pathology is currently unclear, both in familial and in sporadic cases. While the therapeutic effects of L-DOPA and dopamine receptor agonists constitute good options for symptomatic treatment in PD, the development of neuroprotective and/or neurorestorative treatments for PD and other synucleinopathies faces significant challenges due to the poor knowledge of the putative targets. Recent experimental evidence strongly suggests a central role for neurotoxic α-synuclein oligomeric species in neurodegeneration. The events leading to protein oligomerization, as well as the oligomeric species themselves, are likely amenable to modulation by small molecules, which are beginning to emerge in high throughput compound screens in a variety of model organisms. The therapeutic potential of small molecule modulators of oligomer formation demands further exploration and validation in cellular and animal disease models in order to accelerate human drug development.
Practical Provably Correct Voter Privacy Protecting End-to-End Voting Employing Multiparty Computations and Split Value Representations of Votes (2014)

Continuing the work of Rabin and Rivest we present another simple and fast method for conducting end to end voting and allowing public verification of correctness of the announced vote tallying results. This method was referred to in as the SV/VCP method. In the present note voter privacy protection is achieved by use of a simple form of Multi Party Computations (MPC). At the end of vote tallying process, random permutations of the cast votes are publicly posted in the clear, without identification of voters or ballot ids. Thus vote counting and assurance of correct form of cast votes are directly available. Also, a proof of the claim that the revealed votes are a permutation of the concealed cast votes is publicly posted and verifiable by any interested party. Advantages of this method are: Easy understandability by non-­‐cryptographers, implementers and ease of use by voters and election officials. Direct handling of complicated ballot forms. Independence from any specialized primitives. Speed of vote-­‐tallying and correctness proving: elections involving a million voters can be tallied and proof of correctness of results posted within a few minutes.
Integrating Application Security into a Software Development Process (2013)

Static Code Analysis (SCA) is an important means for detecting software vulnerabilities at an early stage in the software development lifecycle. The wide-spread introducing static code analysis at a large software vendor is challenging. Besides the technical challenges, e.g., caused by the large number of software development projects, large number of used programming languages (e.g., ABAP, C, Objective-C, ...), the use of dynamic programming models such as HTML5/JavaScript, there are also many non-technical challenges, e.g, creating security awareness among the developers, organizing trainings, integration of static code analysis into the development and maintenance processes. In this talk, we report the experiences we made while introducing static code analysis at SAP AG.
THE INTERACTION OF GENETIC AND ENVIRONMENTAL FACTORS IN THE CONTROL OF AMYLASE GENE EXPRESSION IN DROSOPHILA MELANOGASTER (1986)

A number of previous studies have established that amylase activity can vary between Drosophila strains which are maintained under identical laboratory conditions. In addition, we have recently shown that all strains examined so far are subject to glucose repression of amylase activity. In this study, we show that the degree of glucose repression can vary between strains. Moreover, the glucose repression effect is much more pronounced in larvae than in adult flies. Our results lead to the conclusion that the strain-specific differences in activity and the dietary effects are not independent phenomena. These results have implications for the interpretation of many studies on amylase activity variation, including those experiments which have been designed to link amylase activity variations with fitness differences in nature. A question that naturally arises concerns the molecular basis for these strain-specific variations in the degree of glucose repression of this eukaryotic gene.
High External Quantum Efficiency Light-Emitting Diodes Enabled by Advanced Heterostructures of Type-II Nanoplatelets (2023)

Colloidal quantum wells (CQWs), also known as nanoplatelets (NPLs), are exciting material systems for numerous photonic applications, including lasers and light-emitting diodes (LEDs). Although many successful type-I NPL-LEDs with high device performance have been demonstrated, type-II NPLs are not fully exploited for LED applications, even with alloyed type-II NPLs with enhanced optical properties. Here, we present the development of CdSe/CdTe/CdSe core/crown/crown (multi-crowned) type-II NPLs and systematic investigation of their optical properties, including their comparison with the traditional core/crown counterparts. Unlike traditional type-II NPLs such as CdSe/CdTe, CdTe/CdSe, and CdSe/CdSe<sub><i>x</i></sub>Te<sub>1-<i>x</i></sub> core/crown heterostructures, here the proposed advanced heterostructure reaps the benefits of having two type-II transition channels, resulting in a high quantum yield (QY) of 83% and a long fluorescence lifetime of 73.3 ns. These type-II transitions were confirmed experimentally by optical measurements and theoretically using electron and hole wave function modeling. Computational study shows that the multi-crowned NPLs provide a better-distributed hole wave function along the CdTe crown, while the electron wave function is delocalized in the CdSe core and CdSe crown layers. As a proof-of-concept demonstration, NPL-LEDs based on these multi-crowned NPLs were designed and fabricated with a record high external quantum efficiency (EQE) of 7.83% among type-II NPL-LEDs. These findings are expected to induce advanced designs of NPL heterostructures to reach a fascinating level of performance, especially in LEDs and lasers.
Genomic Editing Tools to Model Human Diseases with Isogenic Pluripotent Stem Cells (2014)

Patient-specific induced pluripotent stem cells (iPSCs) are considered a versatile resource in the field of biomedicine. As iPSCs are generated on an individual basis, iPSCs may be the optimal cellular material to use for disease modeling, drug discovery, and the development of patient-specific cellular therapies. Recently, to gain an in-depth understanding of human pathologies, patient-specific iPSCs have been used to model human diseases with some iPSC-derived cells recapitulating pathological phenotypes in vitro. However, complex multigenic diseases generally have not resulted in concise conclusions regarding the underlying mechanisms of disease, in large part due to genetic variations between disease-state and control iPSCs. To circumvent this, the use of genomic editing tools to generate perfect isogenic controls is gaining momentum. To date, DNA binding domain-based zinc finger nucleases and transcription activator-like effector nucleases have been utilized to create genetically defined conditions in patient-specific iPSCs, with some examples leading to the successful identification of novel mechanisms of disease. As the feasibility and utility of genomic editing tools in iPSCs improve, along with the introduction of the clustered regularly interspaced short palindromic repeat system, understanding the features and limitations of genomic editing tools and their applications to iPSC technology is critical to expending the field of human disease modeling.
Down‐regulation of macaque ΓΔ+ T cells in lymphoid compartments after rectal infection with SIVsmmPBj14 (2000)

The dynamics of T cells expressing the gammadelta T-cell receptor in mucosae and other compartments during the course of human immunodeficiency virus (HIV)-1 infection are poorly understood. To examine the impact of an acquired immunodeficiency syndrome virus on the gammadelta + T-cell population, rectal inoculation of macaques with simian immunodeficiency virus (SIV)-PBj14 was used as a model. After rectal inoculation, five macaques were sacrificed on days 4, 5, or 7 and then assessed for changes in the gammadelta T-cell receptor repertoire in different lymphoid compartments. There was decreased representation of gammadelta + T cells in the intestinal mucosae, blood, and spleens. Overall, the reduced number of total gammadelta + T cells was consistent with decreases in the Vgamma or Vdelta T-cell sub-populations. Nevertheless, there was no consistent deletion or expansion of a selected Vdelta + or Vdelta + cell sub-population. These results demonstrate that SIV-PBj14 replication and dissemination after mucosal inoculation resulted in a decline of detectable gammadelta + T cells, suggesting that macaque gammadelta + T cells are susceptible to down-regulation or destruction during acute SIV-PBj14 infection.
Rendering Music Performance With Interpretation Variations Using Conditional Variational RNN (2019)

Capturing and generating a wide variety of musical expression is important in music performance rendering, but current methods fail to model such a variation. This paper presents a music performance rendering method that could explicitly model differences in interpretations for a given piece of music. Conditional variational auto-encoder is used to jointly train, conditioned on the music score, an encoder from performance to a latent code and a decoder from the latent code to music performance. Evaluation demonstrates the method is capable of generating a wide variety of human-like expressive music performances as the latent code is varied.
Role of Compressive Sensing Technique in Dose Reduction for Chest Computed Tomography (2014)

More than 90% dose reduction could be achieved with one-fourth sparse-sampled and SubmSv chest CT examination when reconstructed with IRT. Chest CT dose at one fourth of a millisievert with SpS is possible with optimal lesion detection and diagnostic confidence for the evaluation of pulmonary findings.
Supplementary Table from Randomized Phase II Trial of Polyphenon E versus Placebo in Patients at High Risk of Recurrent Colonic Neoplasia (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Faster oscillometric manometry does not sacrifice the accuracy of blood pressure determination (2004)

Faster oscillometry enables one to track rapid pressure changes. We therefore examined whether it was possible to shorten the measurement time without sacrificing accuracy. We accelerated and linearized cuff deflation and determined systolic and diastolic pressure values by the appearance and disappearance of oscillometric waves based on the interpolated cuff pressure-oscillometric wave amplitude relationship. The accuracy of faster oscillometry was examined by comparing correlations between invasive radial and oscillometric brachial pressure with either the conventional or the faster oscillometry in 23 patients (32+/-16 measurement pairs). Faster oscillometry shortened the measurement time from 27.7+/-3.5 s to 17.1+/-2.6 s. Neither pressure levels nor heart rate altered the time required for measurement. Bland-Altman analysis indicated that mean and standard deviation of difference between oscillometric and invasive systolic pressure was comparable (conventional, 2.1+/-7.5 mmHg; faster, 1.4+/-7.3 mmHg) without correlations between difference and average of systolic pressure. Similar differences (conventional, 5.0+/-6.8 mmHg; faster, 4.9+/-5.8 mmHg) and lack of correlations were also found for diastolic pressure. In conclusion, we succeeded in shortening the oscillometric measurement time to approximately 60% of the original time without sacrificing accuracy. This was achieved by acceleration and linearization of cuff deflation and by interpolation of the relationship between cuff pressure and oscillometric wave amplitude.
Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease (2021)

Preparation of foslevodopa and foscarbidopa enables preclinical and clinical PK, safety, and tolerability studies in support of their advancement for the treatment of PD. In phase 1 clinical trials, foslevodopa/foscarbidopa demonstrates consistent and stable LD plasma exposure, supporting further studies of this treatment as a potentially transformational option for those suffering from PD. ANN NEUROL 2021;90:52-61.