gebhart/patrepeval huggingface dataset:
9.9 A 0.6nm resolution 19.8mW eddy-current displacement sensor interface with 126MHz excitation (2017)

Displacement sensing with sub-nanometer resolution is required in advanced metrology and high-tech industry, e.g., to measure the lens position in wafer scanners. Linear encoders and interferometers are often used for this purpose, but they are bulky and costly. Capacitive sensors [1], though compact, are sensitive to environment and require electrical access to the target. Eddy-current sensors (ECSs) do not have these disadvantages, but their resolution and stability are limited by the skin-effect [2-5]. For sub-nm measurements, this can be alleviated by using excitation frequencies >100MHz. This calls for stable flat sensing coils (to minimize parasitics) in close proximity to the ECS interface, whose power dissipation must then be low enough to avoid self-heating and displacement errors due to thermal expansion [2,6].
The Impact of Intentionally Added Water to the Electrolyte of Li-ion Cells (2013)

Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O2/graphite cells with 1 M LiPF6 in EC:EMC (3:7 by wt) with selected electrolyte additives and intentionally added water were studied using the High Precision Charger at Dalhousie University, automated cycling/storage, AC impedance and long term cycling. Water was added at 100 and 1000 ppm levels to control electrolyte and to electrolyte containing 2 wt% vinylene carbonate (VC) and/or 2 wt% lithium bis (trifluoromethanesulphonyl) imide (LiTFSI or 3M Fluorad Lithium HQ-115). The addition of 100 ppm water to control electrolyte had minimal impact on first cycle irreversible capacity loss, cell swelling, measured coulombic efficiency and charge end point capacity slippage rate. The addition of 100 and 1000 ppm water to either VC or VC + HQ-115-containing electrolyte resulted in small changes in coulombic efficiency, charge end point capacity slippage, voltage drop during storage and charge transfer resistance, however in all cases the addition of 1000 ppm water was, surprisingly, beneficial compared to no added water. The only exception was that the addition of 1000 ppm water led to an increase in cell swelling. As predicted by the early high precision measurements, the cells containing water did not show major differences in long term cycling at both 40 and 55°C. This shows that at these relatively low loading levels of water in the electrolyte there are no obvious detrimental effects to cell performance and therefore it may be possible to relax water content specifications in Li-ion battery electrolyte leading to one avenue for cost reduction. Interestingly, the addition of HQ-115 reduced the impedance rise and capacity loss during long term cycling of cells containing both VC and water, suggesting that HQ-115 is a useful additive under conditions where moisture may not be controlled to tight tolerances.
Taiji (2019)

We present Taiji, a new system for managing user traffic for large-scale Internet services that accomplishes two goals: 1) balancing the utilization of data centers and 2) minimizing network latency of user requests.
Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues. (1991)

Rabbit and human tissues contain substantial amounts of an unusual lipid, a fatty acid ester of a pentacyclic triterpene, that is a potent in vitro inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). A possible origin of the triterpene ester is via dietary absorption of plant triterpenes (which have a similar structure to the triterpene moiety of the animal triterpene ester), followed by fatty acid esterification of the triterpene in animal tissues. To support this idea, homogenates of rabbit and human enterocytes and liver are now shown to contain an acyl-CoA:triterpene acyltransferase activity (ATAT) which esterifies triterpene to a fatty acid. The enzyme activity was stimulated by exogenous triterpene and required ATP and coenzyme A when fatty acid was used as substrate; ATP and coenzyme A were not required when fatty acyl-CoA was used. ATAT was not inhibited by two structurally different ACAT inhibitors, which may indicate that ACAT and ATAT are different enzymes. Rat enterocytes and liver contained very little ATAT activity, consistent with the finding that rat liver contained very little triterpene ester. To establish that triterpene esterification occurs in vivo, [3H]triterpene was shown to be incorporated into triterpene ester in several organs and tissues from a rabbit given a gastric bolus of the labeled triterpene. These data provide support for the hypothesis that triterpene esters in animal tissues arise from the dietary absorption of triterpenes followed by the esterification of the triterpenes by an enzymatic activity in the animal tissues.
Robustness of the reference symbol assisted multistage successive interference cancelling receiver with imperfect parameter estimates (2002)

This paper investigates the sensitivity to system imperfections of a multistage successive interference cancelling receiver with reference symbol assisted channel estimation. In particular, performance losses due to nonideal transmitter power amplifier gating, imperfect power control and synchronization errors in the RAKE receiver are determined. The results show that for path loss exponent of 4. Imperfect amplifier gating causes a relatively minor decrease in the system capacity while no such effect is observed for path loss exponents of 2 and 3. As expected, relaxing of power control has a similar capacity reducing effect. In spite of these two effects the resultant capacity is still significantly higher than that with the conventional matched filter receiver. Chip synchronization errors of the order to be expected in a properly designed CDMA system also have only minimal influence on performance. Therefore, conventional synchronization algorithms should perform adequately with successive interference cancelling receivers considered in the paper.
The Dependency of Bioactive Follicle-Stimulating Hormone Secretion on Gonadotropin-Releasing Hormone in Hypogonadal and Cycling Women* (1988)

An antagonist analog of GnRH, (Ac-delta 3-Pro1,p-F-D-Phe2,D-Trp3,6)GnRH (4F-antagonist), was administered to normal women and women with hypergonadotropic hypogonadism. Serum FSH levels were determined by both the granulosa cell aromatase bioassay and RIA. The constant infusion of 4F-antagonist (30 micrograms/kg.h) to the four hypogonadal women resulted in a more pronounced decline in bioactive FSH (62%) than in immunoreactive FSH levels (30%), and the FSH bioactive to immunoreactive ratio decreased significantly (P less than 0.05). Infusion of 4F-antagonist in normal women in the midfollicular phase revealed a similar pattern of suppression of bioactive (64%) and immunoreactive FSH (29%). When 4F-antagonist was administered sc at a dose of 80 micrograms/kg twice daily for 3 days to normal women in the midfollicular phase of their cycles, the bioactive FSH response was biphasic, with the maximal decrease on the second day, followed by return to basal levels on the third day. Correspondingly, there was a precipitous decline in serum estradiol (apparent demise of the dominant follicle), followed by a progressive rise in estradiol levels. Thus, in contrast to immunoreactive FSH levels, bioactive FSH more clearly reflects the biological action of FSH on the follicle in response to GnRH antagonist administration in women. The disparity in the quantitative decline between serum bioactive and immunoreactive FSH levels after presumed blockade of the GnRH receptor may reflect the microheterogeneity of the FSH molecule and suggests that alterations in the biological activity of secreted FSH may be GnRH dependent.
Compressing large polygonal models (2005)

Presents an algorithm that uses partitioning and gluing to compress large triangular meshes which are too complex to fit in main memory. The algorithm is based largely on the existing mesh compression algorithms, most of which require an 'in-core' representation of the input mesh. Our solution is to partition the mesh into smaller submeshes and compress these submeshes separately using existing mesh compression techniques. Since a direct partition of the input mesh is out of question, instead we partition a simplified mesh and use the partition on the simplified model to obtain a partition on the original model. In order to recover the full connectivity, we present a simple scheme for encoding/decoding the resulting boundary structure from the mesh partition. When compressing large models with few singular vertices, a negligible portion of the compressed output is devoted to gluing information. On desktop computers, we have run experiments on models with millions of vertices, which could not be compressed using standard compression software packages, and have observed compression ratios as high as 17 to 1 using our technique.
Regulatory Effect of Common Promoter Polymorphisms on the Expression of the <i>11</i>β<i>-Hydroxysteroid Dehydrogenase Type 1 </i>Gene (2009)

The variations in HSD11B1 were not associated with susceptibility to type 2 diabetes or metabolic phenotypes in Koreans. However, the common promoter variants of the gene might exert a polymorphic regulatory effect on HSD11B1 expression.
Clinical studies of cancer radioimmunodetection with carcinoembryonic antigen monoclonal antibody fragments labeled with 123I or 99mTc. (1990)

Seventy-three patients with diverse cancers containing carcinoembryonic antigen received 123I-labeled anti-carcinoembryonic antigen monoclonal antibody F(ab')2 fragment [38 patients], 99mTc-labeled anti-carcinoembryonic antigen monoclonal antibody Fab' fragment [23 patients], or both reagents at different times [6 patients] for evaluation of antibody targeting and imaging [radioimmunodetection (RAID)], using planar and single-photon emission computed tomography. The results indicated that antibody fragments are preferred for early tumor imaging (within 24 h). Rapid targeting and clearance from blood and normal organs of the antibody fragments (blood median t1/2 elimination of 26.5 and 13.2 h for the F(ab')2 and Fab' fragments respectively) permitted the use of short-lived radionuclides, such as 123I (13.3 h) and 99mTc (6 h), and confirmed that selective antibody accretion in tumors occurred very soon after administration, such as between 2 and 5 h. Scan interpretations at 24 h for the 123I-labeled F(ab')2 and at 2-5 h for the 99mTc-labeled Fab' revealed overall sensitivities, on a tumor site basis, of 95.9 and 94.9%, respectively. On a site basis, the overall accuracies were 94.2 and 93.8% for the 123I and 99mTc immunoconjugates, respectively. In the 6 patients studied with both radioimmunoconjugates, a high concordance in detection was found. Both imaging agents also revealed a high number of putatively new tumor sites not disclosed by other radiological methods at the time of the RAID studies, of which 40.0 and 20.5% were subsequently confirmed as tumor for the 123I and 99mTc agents, respectively, within an 11-month follow-up period. This represented 24 proven occult tumor sites in 19 patients given the 123I-immunoconjugate and 16 proven occult tumor sites in 9 patients receiving the 99mTc agent. The new lesions were found up to 17 and 7 months earlier for 123I-RAID and 99mTc-RAID, respectively, than with other detection methods. The smallest tumors identified were below 0.5 cm, especially with the 99mTc immunoconjugate and single-photon emission computed tomography imaging. The findings of this study confirm previous evidence that RAID is a safe and a potentially useful new method of cancer detection. Despite the excellent results with the 123I-F(ab')2 antibody fragment, its poor availability and high cost limit its clinical use. Therefore, the 99mTc agent, which is made by an instant, 1-step, 1-vial, direct labeling method, appears to be the method of choice for rapid and accurate detection of cancer by RAID.
Enhancement of ethylene production by alkali metal doping of MoVSb mixed oxide catalyst for ethane oxidative dehydrogenation (2023)

Hydrothermally prepared Mo-V-Sb mixed oxides doped with alkali metal cations (Li+, Na+, K+, Rb+, or Cs+) show a significantly improved catalytic behavior in the oxidative dehydrogenation of ethane (ODH) compared to conventional alkali metal-free MoVSbO catalysts. Initial selectivity to ethylene above 95 % was held up to 20 % of ethane conversion for all alkali metal promoted MoVSbO catalysts, as well as lower ethylene overoxidation at higher ethane conversion, with differences depending on the alkali metal employed. Thus, from Li to K, the enhanced catalytic performance follows a bottom-up trend as increasing the size of the cation. An intermediate behavior is observed though for the catalyst doped with Cs cations, with the highest atomic radius. The K-doped MoVSbO catalyst is the least prone to both ethane total oxidation and ethylene overoxidation, which enables up to 90 % selectivity to ethylene at ethane conversion higher than 65 %.
Crystallization screening test for the whole-cell project onThermus thermophilusHB8 (2008)

It was essential for the structural genomics of Thermus thermophilus HB8 to efficiently crystallize a number of proteins. To this end, three conventional robots, an HTS-80 (sitting-drop vapour diffusion), a Crystal Finder (hanging-drop vapour diffusion) and a TERA (modified microbatch) robot, were subjected to a crystallization condition screening test involving 18 proteins from T. thermophilus HB8. In addition, a TOPAZ (microfluidic free-interface diffusion) designed specifically for initial screening was also briefly examined. The number of diffraction-quality crystals and the time of appearance of crystals increased in the order HTS-80, Crystal Finder, TERA. With the HTS-80 and Crystal Finder, the time of appearance was short and the rate of salt crystallization was low. With the TERA, the number of diffraction-quality crystals was high, while the time of appearance was long and the rate of salt crystallization was relatively high. For the protein samples exhibiting low crystallization success rates, there were few crystallization conditions that were common to the robots used. In some cases, the success rate depended greatly on the robot used. The TOPAZ showed the shortest time of appearance and the highest success rate, although the crystals obtained were too small for diffraction studies. These results showed that the combined use of different robots significantly increases the chance of obtaining crystals, especially for proteins exhibiting low crystallization success rates. The structures of 360 of 944 purified proteins have been successfully determined through the combined use of an HTS-80 and a TERA.
Quantum Hall effect on top and bottom surface states of topological insulator (Bi1−xSbx)2Te3 films (2015)

The three-dimensional topological insulator is a novel state of matter characterized by two-dimensional metallic Dirac states on its surface. To verify the topological nature of the surface states, Bi-based chalcogenides such as Bi2Se3, Bi2Te3, Sb2Te3 and their combined/mixed compounds have been intensively studied. Here, we report the realization of the quantum Hall effect on the surface Dirac states in (Bi1-xSbx)2Te3 films. With electrostatic gate-tuning of the Fermi level in the bulk band gap under magnetic fields, the quantum Hall states with filling factor ±1 are resolved. Furthermore, the appearance of a quantum Hall plateau at filling factor zero reflects a pseudo-spin Hall insulator state when the Fermi level is tuned in between the energy levels of the non-degenerate top and bottom surface Dirac points. The observation of the quantum Hall effect in three-dimensional topological insulator films may pave a way toward topological insulator-based electronics.
GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma (2020)

Hepatocellular carcinoma (HCC) remains a leading malignancy with a high mortality and little improvement in treatments. Protein drugs though known for their extraordinary potency and specificity have rarely been investigated for HCC therapy owing to lack of appropriate delivery systems. Here, we designed GE11 peptide-installed chimaeric polymersomes (GE11-CPs) for high-efficiency EGFR-targeted protein therapy of orthotopic SMMC-7721 HCC-bearing nude mice. GE11-CPs were assembled from poly(ethylene glycol)-b-poly(trimethylene carbonate-co-dithiolane trimethylene carbonate)-b-poly(aspartic acid) (PEG-P(TMC-DTC)-PAsp) and GE11-functionalized PEG-P(TMC-DTC), which allowed efficient loading and protection of proteins in the watery interior and fine-tuning of GE11 densities at the surface. CPs with short PAsp segments (degree of polymerization (DP) = 5, 10 and 15) exhibited a protein loading efficiency of 60%-72% and glutathione-responsive protein release. Saporin-loaded GE11-CPs had a size of 36 - 62 nm depending on GE11 densities and DP of PAsp. Notably, GE11-CPs with 10% GE11 revealed greatly enhanced uptake in SMMC-7721 cells, boosting the anticancer potency of saporin for over 3-folds compared with non-targeted control (half-maximal inhibitory concentration (IC<sub>50</sub>) = 11.0 versus 36.3 nM). The biodistribution studies using Cy5-labeled cytochrome C as a model protein demonstrated about 3-fold higher accumulation of GE11-CPs formulation than CPs counterpart in both subcutaneous and orthotopic SMMC-7721 tumor models. Notably, saporin-loaded GE11-CPs revealed low toxicity, effective tumor inhibition and significant improvement of survival rate compared with PBS and non-targeted groups (median survival time: 99 versus 37 and 42 days). EGFR-targeted chimaeric polymersomes carrying proteins appear an interesting HCC treatment modality.
SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases (2014)

The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Aurora inhibitors. Indeed, over 10 of them have reached the clinic as potential anticancer therapies. We report herein the discovery and optimization of a novel series of tricyclic molecules that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy. We also provide insights into its mode of binding to its target proteins, which could explain its selectivity.
Population structure and diversity of avian isolates of Pasteurella multocida from Australia (1998)

A total of 110 isolates of Pasteurella multocida from Australian poultry and reference strains for the 16 somatic serovars plus the three subspecies (gallicida, multocida, septica) were analysed to examine their population structure and diversity. The 81 field isolates examined by multilocus enzyme electrophoresis (MLEE) were diverse, being divided into 56 electrophoretic types (ETs), with the 19 reference strains in another 15 ETs. The population was clonal and somatic serotyping was not particularly useful in establishing relationships between isolates. The 71 ETs formed three distinct subclusters (A, B and C) at a genetic distance of 0.36. Biovars tended to be associated with these subclusters: A with biovars 1, 3, 4, 5 and 8 and B with biovars 2, 6, 7, 9 and 10. Ribotyping, performed on all 110 isolates using Hpall, recognized 21 ribotypes forming nine clusters (R1-R9). The isolates in ribotype cluster R1 were almost identical to those in MLEE cluster B. Using both MLEE and ribotyping, the 19 non-Australian reference strains were found to be distributed over the full diversity of the Australian isolates of P. multocida. This study has shown that a range of P. multocida clones are associated with fowl cholera in Australia and that many of the Australian isolates are similar to non-Australian reference strains. Both the MLEE results and the ribotyping data identified a previously unrecognized subset of P. multocida strains.
Signatures Magazine: RIT's journal of art and literature 1991-1992 (1992)

Signatures Magazine is an RIT student publication, featuring student works of art and literature. Issued annually each spring.
Animal cell hydraulics (2009)

Water is the dominant ingredient of cells and its dynamics are crucial to life. We and others have suggested a physical picture of the cell as a soft, fluid-infiltrated sponge, surrounded by a water-permeable barrier. To understand water movements in an animal cell, we imposed an external, inhomogeneous osmotic stress on cultured cancer cells. This forced water through the membrane on one side, and out on the other. Inside the cell, it created a gradient in hydration, that we visualized by tracking cellular responses using natural organelles and artificially introduced quantum dots. The dynamics of these markers at short times were the same for normal and metabolically poisoned cells, indicating that the cellular responses are primarily physical rather than chemical. Our finding of an internal gradient in hydration is inconsistent with a continuum model for cytoplasm, but consistent with the sponge model, and implies that the effective pore size of the sponge is small enough to retard water flow significantly on time scales ( approximately 10-100 seconds) relevant to cell physiology. We interpret these data in terms of a theoretical framework that combines mechanics and hydraulics in a multiphase poroelastic description of the cytoplasm and explains the experimentally observed dynamics quantitatively in terms of a few coarse-grained parameters that are based on microscopically measurable structural, hydraulic and mechanical properties. Our fluid-filled sponge model could provide a unified framework to understand a number of disparate observations in cell morphology and motility.
Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case (2012)

We propose an experimental strategy for highly accurate selection of candidates for bacterial vaccines without using in vitro and/or in vivo protection assays. Starting from the observation that efficacious vaccines are constituted by conserved, surface-associated and/or secreted components, the strategy contemplates the parallel application of three high throughput technologies, i.e. mass spectrometry-based proteomics, protein array, and flow-cytometry analysis, to identify this category of proteins, and is based on the assumption that the antigens identified by all three technologies are the protective ones. When we tested this strategy for Group A Streptococcus, we selected a total of 40 proteins, of which only six identified by all three approaches. When the 40 proteins were tested in a mouse model, only six were found to be protective and five of these belonged to the group of antigens in common to the three technologies. Finally, a combination of three protective antigens conferred broad protection against a panel of four different Group A Streptococcus strains. This approach may find general application as an accelerated and highly accurate path to bacterial vaccine discovery.
Safety-Critical Control of Systems with Time-Varying Input Delay (2021)

In this paper, we describe an approach for designing safety-critical controllers for nonlinear systems with time-varying input delay. This approach involves combining a safe, control barrier function (CBF) based feedback law for the nominal delay-free system with a state predictor that compensates the time-varying input delay. We show that under predictor-feedback, a safe feedback law designed for the nominal system achieves the same closed-loop safety properties for the input-delayed system, provided the system remains safe before the controller kicks in. We include two numerical examples that illustrate the effectiveness of our approach.
Targeting cancer with bispecific antibodies (2021)

Bispecific antibodies might provide off-the-shelf immunotherapeutics for treating cancer