gebhart/patrepeval huggingface dataset:
An investigation of breakdown voltage in AMTECs (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yoichi Momozaki, Mohamed S. El-Genk; An investigation of breakdown voltage in AMTECs. AIP Conf. Proc. 14 January 2002; 608 (1): 972–979. https://doi.org/10.1063/1.1449827 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Total Synthesis and Antimicrobial Activities of All Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide (2018)

As promising antifungal agents, the eight stereoisomers of eushearilide, including the natural compound, were synthesized relying on an asymmetric Mukaiyama aldol reaction, Julia-Kocienski olefination, and Shiina macrolactonization. Moreover, their in vitro antimicrobial activities against some fungi and bacteria were evaluated by the disk-diffusion method, which revealed that not only natural eushearilide but also its stereoisomers exhibited significant antimicrobial activity against a variety of fungi and bacteria.
Perceptual Quality Metrics for 3D Meshes: Towards an Optimal Multi-attribute Computational Model (2013)

3D graphical data, commonly represented using triangular meshes, are deployed in a wide range of application processes including compression, filtering, watermarking, and simplification. These processes often introduce geometric distortions which affect the visual quality of the ultimate data visualization. In order to accurately evaluate perceptual impacts caused by the distortions, assessment metrics on 3D Mesh Visual Quality (MVQ) have been extensively discussed in the literature. Researchers recommended various metrics to predict the adverse effects that visual artifacts can have in applications. Most of these metrics are based on geometric attributes, conventional geometric distance, Laplacian coordinates, different types of curvature computation, and dihedral angles. We hypothesize that an optimal combination of multiple attributes associated with a 3D mesh surface can contribute to better perceptual prediction than single attributes used separately. In this paper, we use two user studies to validate our hypothesis. Our contributions are: (1) providing a detailed analysis of the most relevant geometric attributes for mesh quality assessment, and (2) introducing a new perceptual evaluation metric based on multiple attributes, with the optimal combination determined through machine learning techniques. Statistical quantitative analysis shows that our metric delivers better results than other state-of-the-art approaches. The proposed method is simple to implement and fast in execution. Moreover, our framework can easily be expanded to accommodate additional surface attributes.
Computer vision algorithms on reconfigurable logic arrays (1999)

Computer vision algorithms are natural candidates for high performance computing systems. Algorithms in computer vision are characterized by complex and repetitive operations on large amounts of data involving a variety of data interactions (e.g., point operations, neighborhood operations, global operations). In this paper, we describe the use of the custom computing approach to meet the computation and communication needs of computer vision algorithms. By customizing hardware architecture at the instruction level for every application, the optimal grain size needed for the problem at hand and the instruction granularity can be matched. A custom computing approach can also reuse the same hardware by reconfiguring at the software level for different levels of the computer vision application. We demonstrate the advantages of our approach using Splash 2-a Xilinx 4010-based custom computer.
Gonadotropin‐releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis (2018)

GnRHa induces downregulation of TNS1 in tissue and serum in women with endometriosis. These results emphasize the importance TNS1 as a potential therapeutic molecular target for the treatment of endometriosis with GnRHa.
Complete nucleotide sequence and annotation of the temperate corynephage ϕ16 genome (2017)

The complete genome of ϕ16, a temperate corynephage from Corynebacterium glutamicum ATCC 21792, was sequenced and annotated (GenBank: KY250482). The electron microscopy study of ϕ16 virion confirmed that it belongs to the family Siphoviridae. The ϕ16 genome consists of a linear double-stranded DNA molecule of 58,200 bp (G+C = 52.2%) with protruding cohesive 3'-ends of 14 nt. Four major structural proteins were separated by SDS-PAGE and identified by peptide mass fingerprinting technique. Using bioinformatics analysis, 101 putative ORFs and 5 tRNA genes were predicted. Only 27 putative gene products could be assigned to known biological functions. The ϕ16 genome was divided into functional modules. Seven putative promoters and eight putative unidirectional intrinsic terminators were predicted. One site of putative «-1» programmed ribosomal frameshifting was proposed in the phage tail assembly genome region. C. glutamicum genetic tools could be broadened by exploiting the known integrase gene (gp33) and the newly identified excisionase gene (gp47), participating in site-specific recombination between ϕ16-attP/attB.
Coded Estimation: Design of Backscatter Array Codes for 3D Orientation Estimation (2021)

We consider the problem of estimating the orientation of a 3D object with the assistance of configurable backscatter tags. We explore the idea of designing tag response codes to improve the accuracy of orientation estimation. To minimize the difference between the true and estimated orientation, we propose two code design criteria. We also derive a lower bound on the worst-case error using Le Cam's method and provide simulation results for multiple scenarios including line-of-sight only and multipath, comparing the theoretical bounds to those achieved by the designs.
Dipole aligned energy transfer between excitons in 2D semiconductors and organic materials (2017)

Energy transfer from low mobility material to high mobility material is essential for optoelectronic application. We demonstrate Foster energy transfer from organic material (PTCDA) to monolayer MoSe2 though steady state and transient photoluminescence spectroscopy.
MPC-Based Energy Management of a Power-Split Hybrid Electric Vehicle (2011)

A power-split hybrid electric vehicle (HEV) combines the advantages of both series and parallel hybrid vehicle architectures by utilizing a planetary gear set to split and combine the power produced by electric machines and a combustion engine. Because of the different modes of operation, devising a near optimal energy management strategy is quite challenging and essential for these vehicles. To improve the fuel economy of a power-split HEV, we first formulate the energy management problem as a nonlinear and constrained optimal control problem. Then two different cost functions are defined and model predictive control (MPC) strategies are utilized to obtain the power split between the combustion engine and electrical machines and the system operating points at each sample time. Simulation results on a closed-loop high-fidelity model of a power-split HEV over multiple standard drive cycles and with different controllers are presented. The results of a nonlinear MPC strategy show a noticeable improvement in fuel economy with respect to those of an available controller in the commercial Powertrain System Analysis Toolkit (PSAT) software and the other proposed methodology by the authors based on a linear time-varying MPC.
In situ light spectroscopy in the environmental transmission electron microscope (ETEM) (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Nuclear Targeting of Akt Enhances Ventricular Function and Myocyte Contractility (2005)

Cytoplasmic overexpression of Akt in the heart results in a myopathy characterized by organ and myocyte hypertrophy. Conversely, nuclear-targeted Akt does not lead to cardiac hypertrophy, but the cellular basis of this distinct heart phenotype remains to be determined. Similarly, whether nuclear-targeted Akt affects ventricular performance and mechanics, calcium metabolism, and electrical properties of myocytes is unknown. Moreover, whether the expression and state of phosphorylation of regulatory proteins implicated in calcium cycling and myocyte contractility are altered in nuclear-targeted Akt has not been established. We report that nuclear overexpression of Akt does not modify cardiac size and shape but results in an increased number of cardiomyocytes, which are smaller in volume. Additionally, the heart possesses enhanced systolic and diastolic function, which is paralleled by increased myocyte performance. Myocyte shortening and velocity of shortening and relengthening are increased in transgenic mice and are coupled with a more efficient reuptake of calcium by the sarcoplasmic reticulum (SR). This process increases calcium loading of the SR during relengthening. The enhanced SR function appears to be mediated by an increase in SR Ca2+-ATPase2a activity sustained by a higher degree of phosphorylation of phospholamban. This posttranslational modification was associated with an increase in phospho-protein kinase A and a decrease in protein phosphatase-1. Together, these observations provide a plausible biochemical mechanism for the potentiation of myocyte and ventricular function in Akt transgenic mice. Therefore, nuclear-targeted Akt in myocytes may have important implications for the diseased heart.
Implementation of e-beam proximity effect correction using linear programming techniques for the fabrication of asymmetric bow-tie antennas (2009)

Antenna-coupled tunnel junction diodes have recently been offering great advantages for IR and Terahertz detection applications. Fabrication has been a major constraint in our ability to field these devices. The first obstacle is the relatively small size of the antenna. As the length of the wave to be detected gets smaller, the size of the antenna shrinks according to the ¿/4 rule. This eliminates the use of traditional photolithographic fabrication techniques, which fails in the nanometer geometry range. For this reason, e-beam lithographic technique is used. The second challenge appears in the fabrication of the tunnel junction. The tunnel junction part of the device is formed by sandwiching an insulation layer in between two conductor antenna parts. Previously, many fabrication techniques were offered for the vertical conductor-insulator-conductor (CIC) structures where two metal layers overlap each other forming a tunnel junction vertical to the antenna surface. However, planar CIC structures have become more popular because they enable the surface plasmon excitement across the tunnel junction barrier. The fabrication of planar tunnel junction requires the patterning of a nano-size gap that will enable the tunneling of the electrons in between two conductor antenna wings. At this critical location, e-beam proximity effect (pixel-to-pixel beam interactions) becomes a very important issue to be addressed in order to create a nanometer-range accuracy gap.
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study. (1997)

Patients with advanced lung adenocarcinoma who harbor a ras mutation may have major responses to chemotherapy and have similar progression-free and overall survival as patients with ras mutation-negative tumors. K-ras mutations may represent one of several ways in which early tumors are enabled to metastasize to distant sites.
Hydrolytic Reactivity Trends among Potential Prodrugs of the O2-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity (2008)

Glycosylated diazeniumdiolates of structure R 2NN(O)NO-R' (R' = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but acid-sensitive R 2NN(O)NO (-) ion. Moreover, cleaving the acid-stable glycosides under alkaline conditions provides a convenient protecting group strategy for diazeniumdiolate ions. Here, we report comparative hydrolysis rate data for five representative glycosylated diazeniumdiolates at pH 14, 7.4, and 3.8-4.6 as background for further developing both the protecting group application and the ability to target NO pharmacologically to macrophages harboring intracellular pathogens. Confirming the potential in the latter application, adding R 2NN(O)NO-GlcNAc (where R 2N = diethylamino or pyrrolidin-l-yl and GlcNAc = N-acetylglucosamin-l-yl) to cultures of infected mouse macrophages that were deficient in inducible NO synthase caused rapid death of the intracellular protozoan parasite Leishmania major with no host cell toxicity.
Fluctuation-Induced Phenomena in Nanoscale Systems: Harnessing the Power of Noise (2012)

The famous Johnson-Nyquist formula relating noise current to conductance has a microscopic generalization relating noise current density to microscopic conductivity, with corollary relations governing noise in the components of the electromagnetic fields. These relations, known collectively in physics as fluctuation-dissipation relations, form the basis of the modern understanding of fluctuation-induced phenomena, a field of burgeoning importance in experimental physics and nanotechnology. In this review, we survey recent progress in computational techniques for modeling fluctuation-induced phenomena, focusing on two cases of particular interest: near-field radiative heat transfer and Casimir forces. In each case we review the basic physics of the phenomenon, discuss semianalytical and numerical algorithms for theoretical analysis, and present recent predictions for novel phenomena in complex material and geometric configurations.
Immunological considerations for developing antibody therapeutics for Influenza A (2015)

Influenza infection can give rise to serious illness leading to complications and hospitalization of patients. The efficacy of current standard of care is very limited and provides little relief for patients hospitalized with serious flu. Human monoclonal antibodies (mAb) against influenza are being developed as new treatment options for this patient population. When developing antibody therapeutics, it is important to consider all possible immunologic effects of the antibodies on viral infection and disease progression including those other than the postulated therapeutic mechanisms. An area of concern is the potential of antibody-dependent enhancement (ADE) of illness. ADE of viral infections has been extensively described for Dengue virus (DENV) but not for influenza. Recently, preliminary results from clinical viral challenge studies of anti-HA-stalk mAbs suggested the possibility of enhanced viral shedding, raising concerns for ADE when utilizing mAbs as therapeutic intervention for influenza although viral shedding was not enhanced in the clinical viral challenge of anti-M2 mAb TCN-032. We herein discuss the known mechanisms of ADE and their relevance to developing mAbs such as anti-HA and anti-M2 for influenza disease.
Control of Acetyl-Coenzyme A Synthetase (AcsA) Activity by Acetylation/Deacetylation without NAD + Involvement in Bacillus subtilis (2006)

Posttranslational modification is an efficient mechanism for controlling the activity of structural proteins, gene expression regulators, and enzymes in response to rapidly changing physiological conditions. Here we report in vitro and in vivo evidence that the acuABC operon of the gram-positive soil bacterium Bacillus subtilis encodes a protein acetyltransferase (AcuA) and a protein deacetylase (AcuC), which may control the activity of acetyl-coenzyme A (CoA) synthetase (AMP-forming, AcsA) in this bacterium. Results from in vitro experiments using purified proteins show that AcsA is a substrate for the acetyl-CoA-dependent AcuA acetyltransferase. Mass spectrometry analysis of a tryptic digest of acetylated AcsA (AcsA(Ac)) identified residue Lys549 as the sole modification site in the protein. Unlike sirtuins, the AcuC protein did not require NAD(+) as cosubstrate to deacetylate AcsA(Ac). The function of the putative AcuB protein remains unknown.
Semistochastic Quadratic Bound Methods (2018)

Partition functions arise in a variety of settings, including conditional random fields, logistic regression, and latent gaussian models. In this paper, we consider semistochastic quadratic bound (SQB) methods for maximum likelihood estimation based on partition function optimization. Batch methods based on the quadratic bound were recently proposed for this class of problems, and performed favorably in comparison to state-of-the-art techniques. Semistochastic methods fall in between batch algorithms, which use all the data, and stochastic gradient type methods, which use small random selections at each iteration. We build semistochastic quadratic bound-based methods, and prove both global convergence (to a stationary point) under very weak assumptions, and linear convergence rate under stronger assumptions on the objective. To make the proposed methods faster and more stable, we consider inexact subproblem minimization and batchsize selection schemes. The efficacy of SQB methods is demonstrated via comparison with several state-of-the-art techniques on commonly used datasets.
Исторические аспекты нормативно-правового регулирования работы аптек как структурных подразделений медицинских организаций (2022)

Along with the development and improvement of the structure of medical organizations, much attention is paid to the drug provision of the therapeutic and diagnostic process in them, which contributes to improving the quality of medical care. Our theoretical research is based on a practical analysis of empirical data of regulatory and legal acts and documents regulating the issues of drug provision of medical organizations in Russia and abroad. Structural and functional analysis by the authors was used in the study of abstract and full-text databases published in digital online resources with materials of drug provision for medical and diagnostic work; infographics and scientific articles. The study has revealed that a number of requirements for pharmaceutical activities of pharmacy organizations and modern requirements for drug provision for the implementation of therapeutic and diagnostic activities do not correspond to the dynamic development of drug provision for patients of medical organizations. We came to the conclusion that, in modern conditions of the development of medical care to the population, in general, there are enough regulatory legal acts and documents for the organization of the work of pharmacy organizations as structural divisions of medical organizations. But, if we take into account the diversity of medical organizations, their profile, the possibility of changing the structure of medical departments, directions of medical care, then this may require changing the nomenclature of ready-made and manufactured medicines in specific conditions. As the results of the study have shown, joint efforts of all stakeholders in pharmacy and healthcare, as well as regulators of pharmaceutical and medical activities are needed to develop standard organizational and methodological recommendations for medical organizations carrying out medical and diagnostic activities based on the best traditions of Good Pharmacy Practice (GPP) and the International Pharmaceutical Federation (FIP). At the heart of this work, in our opinion, it is necessary to organize experimental studies using functional mathematical models of pharmacy activity in a number of therapeutic and preventive medical organizations to digitalize the organization of drug provision in them with expert evaluation of the results by specialists of all interested parties.
ChemInform Abstract: N‐(Deoxyguanosin‐8‐yl)aniline from the in‐vitro Reaction of N‐Acetoxyaniline with Deoxyguanosine and DNA. (1989)

Abstract N‐Acetoxyaniline (III), the isolation and characterization of which is described for the first time, reacts with both pure deoxyguanosine and deoxyguanosine bound on DNA to give the adduct (IV).
Efficient POC-based Correspondence Detection Method for Multi-channel Images (2014)

We propose a new POC (phase-only correlation)-based highaccuracy correspondence detection method for multi-channel images. There is the possibility of improving detection accuracy because conventional POC-based methods do not use color information. In the proposed method, a normalized cross spectrum (or cross-phase spectrum) and weight are calculated for each color channel in the Fourier domain. The weight is determined by the amplitude of the cross spectrum. The weighted normalized cross spectra of all color channels are combined and inverse Fourier transformation is conducted to obtain a POC function. An experimental evaluation of the matching accuracy between the conventional POC-based method and the proposed method shows that RMSE decreased approximately 25%. This paper also describes an application of the proposed method to a stereo image matching. The average detection ratio of correspondences between a stereo-pare image is improved 64% to 95%.
Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2 (2021)

Recent Advancements in Hematology: Knowledge, Methods and Dissemination is a series of commentary article which is published on a biannual basis by the editorial board of the journal Hemato [...]
ChemInform Abstract: Catalytic Routes to Hydro(chloro)fluorocarbons (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Spin effects in MoS2 and WS2 single layers (2015)

magnified image Replacing the two sublattices of carbon atoms in graphene with transition metal atoms and chalcogenide dimers results in single layers of transition metal dichalcogenides (TMDCs). TMDCs are promising new materials for light and energy harvesting, transistors, sensors and quantum information processing. One way to access the distinctive functionality of these materials is via their optical selection rules. In particular, light with positive or negative helicity is absorbed differently, therefore, understanding the interaction of circularly polarized light with various TMDCs should enable future applications. Using the examples of MoS 2 and WS 2 we summarize some recent results that illustrate the potential of these materials. First, when optically excited with circularly polarized light, single layers of MoS 2 can emit light with an appreciable polarization. Depolarization mechanisms can be subsequently explored by monitoring the polarization of emitted photoluminescence as a function of the excess energy supplied to the system. As the energy of the pumping light increases further from the emission channel, the emission quickly becomes depolarized. The dominant relaxation mechanism is identified as phonon‐assisted intervalley scattering. In single layers of WS 2 containing electron gas, the main emission channel is from negatively charged excitons, or trions. In the presence of a two‐dimensional electron gas this trion emission is circularly polarized at zero magnetic field, even when excited with linearly polarized light. This spontaneous circular polarization of the trion has a linear dependence on magnetic field and can be attributed to the existence of a valley polarized state of the two‐dimensional electron gas. (© 2015 WILEY‐VCH Verlag GmbH &amp;Co. KGaA, Weinheim)