gebhart/patrepeval huggingface dataset:
Towards Mechanistic Understanding of Liquid‐Phase Cinnamyl Alcohol Oxidation with tert‐Butyl Hydroperoxide over Noble‐Metal‐Free LaCo1–xFexO3 Perovskites (2019)

Noble-metal-free perovskite oxides are promising and well-known catalysts for high-temperature gas-phase oxidation reactions, but their application in selective oxidation reactions in the liquid phase has rarely been studied. We report the liquid-phase oxidation of cinnamyl alcohol over spray-flame synthesized LaCo<sub>1-x</sub> Fe<sub>x</sub> O<sub>3</sub> perovskite nanoparticles with tert-butyl hydroperoxide (TBHP) as the oxidizing agent under mild reaction conditions. The catalysts were characterized by XRD, BET, EDS and elemental analysis. LaCo<sub>0.8</sub> Fe<sub>0.2</sub> O<sub>3</sub> showed the best catalytic properties indicating a synergistic effect between cobalt and iron. The catalysts were found to be stable against metal leaching as proven by hot filtration, and the observed slight deactivation is presumably due to segregation as determined by EDS. Kinetic studies revealed an apparent activation energy of 63.6 kJ mol<sup>-1</sup> . Combining kinetic findings with TBHP decomposition as well as control experiments revealed a complex reaction network.
Measurement of forward Z → e+e− production at s = 8 $$ \sqrt{s}=8 $$ TeV (2015)

A measurement of the cross-section for Z-boson production in the forward region of pp collisions at 8 TeV centre-of-mass energy is presented. The measurement is based on a sample of Z e + e -decays reconstructed using the LHCb detector, corresponding to an integrated luminosity of 2.0 fb -1 . The acceptance is defined by the requirements 2.0 < < 4.5 and p T > 20 GeV for the pseudorapidities and transverse momenta of the leptons. Their invariant mass is required to lie in the range 60-120 GeV. The cross-section is determined to be (pp Z e + e -) = 93.81 0.41(stat) 1.48(syst) 1.14(lumi) pb , where the first uncertainty is statistical and the second reflects all systematic effects apart from that arising from the luminosity, which is given as the third uncertainty. Differential cross-sections are presented as functions of the Z-boson rapidity and of the angular variable * , which is related to the Z-boson transverse momentum.
Ghost Femtocells: an Energy-Efficient Radio Resource Management Scheme for Two-Tier Cellular Networks (2011)

www.vde-verlag.de/proceedings-en/563343114.html - ISBN: 978-3-8007-3343-9
Coexistence of lte and radar systems methodology for benchmarking cooperative radar receiver performance (2017)

As the need to satisfy the global demand for wireless services continues, the pressure for valuable spectrum adjacent to radiolocation services is a topic of contention between incumbent spectrum users and national spectrum policy makers and regulators. The study of the coexistence of radar systems and modern LTE communications systems tend to focus on the measurements of the spectrum impacts of the radar transmission and the interference assessment of the LTE base station receiver. The study and measure of impact on the radar receiver has been studied mainly in theory. In this paper, the methodology and technique for benchmarking the radar receiver performance of cooperative radar systems in the presence of wireless systems is proposed.
High‐Concentration Aqueous Dispersions of Nanoscale 2D Materials Using Nonionic, Biocompatible Block Copolymers (2015)

Conditions for the dispersion of molybdenum disulfide (MoS2) in aqueous solution at concentrations up to 0.12 mg mL(-1) using a range of nonionic, biocompatible block copolymers (i.e., Pluronics and Tetronics) are identified. Furthermore, the optimal Pluronic dispersant for MoS2 is found to be effective for a range of other 2D materials such as molybdenum diselenide, tungsten diselenide, tungsten disulfide, tin selenide, and boron nitride.
Continuous Two‐Channel Time‐of‐Flight Mass Spectrometric Detection of Electrosprayed Ions (2004)

Flying to new destinations: Instrument modifications, which give three detection areas (see scheme) in a two-channel detection scheme, extend the achievable duty cycle of a Hadamard transform time-of-flight mass spectrometer (HT-TOFMS) to 100 % and effectively converts TOFMS into a continuous detection technique. Beyond the improved signal-to-noise ratio, this advance gives an increase in the data-acquisition rate leading to a higher detection speed.
Supplementary Figure 1 from Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells (2023)

&lt;p&gt;PDF file - 198KB, MAGE-A3 Trojan Peptide Vaccine Reactogenicity.&lt;/p&gt;
Effects of AV Delay and VV Delay on Left Atrial Pressure and Waveform in Ambulant Heart Failure Patients: Insights into CRT Optimization (2014)

LAP and its waveform changes considerably with AV optimization. There is good agreement between echo-guided optimal setting and LAP. LAP could provide an objective guide to CRT optimization. (Clinical Trial Registry information: URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00632372).
Remarkable Accelerating Effects of Ammonium Cations on Electron-Transfer Reactions of Quinones by Hydrogen Bonding with Semiquinone Radical Anions (2004)

Remarkable accelerating effects of the ammonium cation (NH4+) have been observed on photoinduced electron-transfer reactions from the triplet excited state of tetraphenylporphyin (H2P) to quinones [p-benzoquinone (Q) and naphthoquinone (NQ)] in dimethyl sulfoxide (DMSO). The tetrabutylammonium cation (NBu4+) is also effective to accelerate the electron-transfer reduction of Q and NQ in dichloromethane (CH2Cl2). The hydrogen bonding interaction between the semiquinone radical anion (Q•- or NQ•-) and NH4+ was confirmed by the ESR spectra of the Q•-/NH4+ and Q•-/(NH4+)2 [NQ•-/NH4+ and NQ•-/(NH4+)2] complexes in DMSO. Accelerating effects of NH4+ in DMSO and NBu4+ in CH2Cl2 on the rates of photoinduced electron-transfer reduction of Q by H2P result from the positive shift of the Ered value of quinones together with a constant Eox value of H2P determined from cyclic voltammetry measurements. The driving force dependence of the rate constants for photoinduced electron-transfer reduction of quinones in the presence of various concentrations of ammonium cations was evaluated in light of the Marcus theory of electron transfer.
Correlation of quantitative p95HER2, HER2, and HER3 protein expression with pathologic complete response (pCR) in HER2-positive breast cancer patients (pts) treated with neoadjuvant chemotherapy and trastuzumab. (2012)

137 Background: Elevated p95HER2 [HER2-M611-CTF (carboxy-terminal-fragment) also known as p95] expression has been correlated with poor outcomes in HER2+ pts with metastatic breast cancer treated with trastuzumab (T); however, limited data is available on the correlation between p95 and pCR to T in the neoadjuvant (NEO) setting, where p95 was measured by immunohistochemistry. The current study aims to determine whether quantitative p95, HER3 and HER2 expression correlated with pCR in pts treated with T + chemotherapy in the NEO setting. Methods: pCR data and quantitative HER2 (H2T), p95, and HER3 (H3T) results by HERmark/VeraTag assays were available in 45 patient cases with pre-therapy, formalin-fixed, paraffin-embedded breast tumors. pCR was defined as the absence of invasive disease in the breast. Quantitative biomarker data were correlated with pCR according to previously published or presented biomarker cutoffs. Results: The overall pCR rate was 46.7% (ER+: 14.3% vs. ER-: 75%; p&lt;0.0001) and was significantly associated with higher H2T levels (p=0.02) and lower H3T levels (p=0.04). In ER- subjects (N=24), no difference in H2T levels was observed between pCR vs non-pCR groups (median H2T=111.5 vs 150.5, respectively; p=0.721). However, within the ER+ group (N=21), H2T levels were significantly higher in the pCR group vs non-pCR group (median H2T=254 vs 37.3; p=0.024). Using multivariate logistic regression, increasing log(H2T) (p = 0.012), ER-negativity (p = 0.027) and low p95 (p = 0.074) were found to correlate or trend with pCR. Conclusions: pCR was significantly associated with high H2T, particularly in ER+ HER2+ breast cancer pts who received NEO therapy with T + chemotherapy. Lower H3T was also associated with pCR. A trend towards pCR was seen in tumors with low p95. These data suggest that quantitative H2T, H3T and p95 may provide additional information on response to T-based regimens in breast cancer stratified by ER status. Additional investigation into the relationship between quantitative H2T, p95 and H3T expression and T response in the NEO setting in larger cohorts is warranted.
Instrumental carbon monoxide dosimetry (1980)

Modern technology for the ambient monitoring of carbon monoxide has been developed to produce a portable electrochemical instrument capable of the personal exposure to carbon monoxide. The performance characteristics of this device have been studied so that the unambiguous interpretation of field data could be performed. A study of the carbon monoxide exposure in a light manufacturing facility illustrate that effective dosimetry can be performed with expectations of accuracy typically better than +/- 15%, and that voluntary carbon monoxide exposures such as smoking were a significant contribution to the individual's exposure. Significant definition of the carbon monoxide exposure profile can be achieved with an instrument approach to the collection of the dosimetric data.
Quantum Molecular Dynamics Simulations of Dense Matter (1999)

Abstract We have developed a quantum molecular dynamics simulation method for treating dense plasmas and a variety of other systems. The approach treats the electrons fully quantum mechanically and the nuclei classically. Applications include H plasmas, alkali metal fluids, rare gas compression, mixtures, impurities in plasmas, and shock‐compressed hydrocarbons.
Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment (2014)

Phosphodiesterases (PDEs) regulate the levels of the second messengers cAMP and cGMP and are important drug targets. PDE10A is highly enriched in medium spiny neurons of the striatum and is an attractive drug target for the treatment of basal ganglia diseases like schizophrenia, Parkinson's disease, or Huntington's disease. Here we describe the design, synthesis, and application of a variety of chemical biology probes, based on the first clinically tested PDE10A inhibitor MP-10, which were used to characterize the chemoproteomic profile of the clinical candidate in its native environment. A clickable photoaffinity probe was used to measure target engagement of MP-10 and revealed differences between whole cell and membrane preparations. Moreover, our results illustrate the importance of the linker design in the creation of functional probes. Biotinylated affinity probes allowed identification of drug-interaction partners in rodent and human tissue and quantitative mass spectrometry analysis revealed highly specific binding of MP-10 to PDE10A with virtually no off-target binding. The profiling of PDE10A chemical biology probes described herein illustrates a strategy by which high affinity inhibitors can be converted into probes for determining selectivity and target engagement of drug candidates in complex biological matrices from native sources.
Crowdlicit (2019)

End-user elicitation studies are a popular design method. Currently, such studies are usually confined to a lab, limiting the number and diversity of participants, and therefore the representativeness of their results. Furthermore, the quality of the results from such studies generally lacks any formal means of evaluation. In this paper, we address some of the limitations of elicitation studies through the creation of the Crowdlicit system along with the introduction of end-user identification studies, which are the reverse of elicitation studies. Crowdlicit is a new web-based system that enables researchers to conduct online and in-lab elicitation and identification studies. We used Crowdlicit to run a crowd-powered elicitation study based on Morris's "Web on the Wall" study (2012) with 78 participants, arriving at a set of symbols that included six new symbols different from Morris's. We evaluated the effectiveness of 49 symbols (43 from Morris and six from Crowdlicit) by conducting a crowd-powered identification study. We show that the Crowdlicit elicitation study resulted in a set of symbols that was significantly more identifiable than Morris's.
Tunneling currents and reliability of atomic-layer-deposited SiBCN for low-&#x03BA; spacer dielectrics (2014)

Reduced gate-to-contact thickness is prompting a search for compatible spacer dielectrics with reduced dielectric constants (κ). We compare the reliability of the traditional spacer dielectric, Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> , with a lower κ material, SiBCN. Weibull slopes and power-law exponent are measured to be close to that of SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . Guidance is given on the minimum SiBCN spacer thickness.
Safety and Performance of a Novel Intravascular Catheter for Induction and Reversal of Hypothermia in a Porcine Model (2002)

The data presented here suggest that rapid induction and reversal of hypothermia are technically possible using a core intravenous cooling catheter; this method would provide a safe, rapid, and exquisitely reproducible way to induce hypothermia with subsequent restoration of normothermia.
Web-Structured All-Solid PBG Fiber (2013)

We present a design and manufacture of a web-structured all-solid photonic bandgap fiber. We show experimentally that the loss can be reduced to a practical level (~7 dB/km) with an appropriate design of the web structure.
Different subtypes of epithelioid sarcoma and their clinical implication: long‐term multi‐institutional experience with a rare sarcoma (2017)

Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40%) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.
Zeptosecond High Harmonic keV X-Ray Waveforms Driven by Midinfrared Laser Pulses (2013)

We demonstrate theoretically that the temporal structure of high harmonic x-ray pulses generated with midinfrared lasers differs substantially from those generated with near-infrared pulses, especially at high photon energies. In particular, we show that, although the total width of the x-ray bursts spans femtosecond time scales, the pulse exhibits a zeptosecond structure due to the interference of high harmonic emission from multiple reencounters of the electron wave packet with the ion. Properly filtered and without any compensation of the chirp, regular subattosecond keV waveforms can be produced.
PASOTRON amplifier experiments (1993)

Summary form only given. Experimental studies on a single-stage microwave amplifier based on Hughes' plasma assisted, slow-wave oscillator technology (PASOTRON) are reported. The high-energy microwave amplifier employed in these studies utilizes a plasma-cathode electron-gun, and a plasma-filled slow-wave structure (SWS), to produce and propagate > 100-/spl mu/sec-long, 50-to-100 kV, 80-to-120-A electron-beam pulses without the use of any applied axial magnetic fields. The long-electron-beam pulses are coupled with a 120-/spl mu/sec-long, 10.1-GHz RF-drive signal provided by a 3-kW klystron. As the beam and the drive signal propagate through the SWS, amplification of the input-RF-drive signal is achieved. Amplified power levels of 3-to-7 kW have been achieved to date at maximum efficiencies of only 0.11%. However, measurements of the amplifier gain reveals signal level increases of 17 dB. Preliminary analysis of these results suggests that a frequency-dependent insertion loss of the present SWS when operated near the TM/sub 01/ mode's upper cut-off frequency may be responsible for the amplifier's low measured output power and efficiency, but high system gain.
Theoretical Determination of Size Effects in Zeolite-Catalyzed Alcohol Dehydration (2019)

In the upgrading of biomass pyrolysis vapors to hydrocarbons, dehydration accomplishes a primary objective of removing oxygen, and acidic zeolites represent promising catalysts for the dehydration reaction. Here, we utilized density functional theory calculations to estimate adsorption energetics and intrinsic kinetics of alcohol dehydration over H-ZSM-5, H-BEA, and H-AEL zeolites. The ONIOM (our Own N-layered Integrated molecular Orbital and molecular Mechanics) calculations of adsorption energies were observed to be inconsistent when benchmarked against QM (Quantum Mechanical)/Hartree–Fock and periodic boundary condition calculations. However, reaction coordinate calculations of adsorbed species and transition states were consistent across all levels considered. Comparison of ethanol, isopropanol (IPA), and tert-amyl alcohol (TAA) over these three zeolites allowed for a detailed examination of how confinement impacts on reaction mechanisms and kinetics. The TAA, seen to proceed via a carbocationic mechanism, was found to have the lowest activation barrier, followed by IPA and then ethanol, both of which dehydrate via a concerted mechanism. Barriers in H-BEA were consistently found to be lower than in H-ZSM-5 and H-AEL, attributed to late transition states and either elevated strain or inaccurately estimating long-range electrostatic interactions in H-AEL, respectively. Molecular dynamics simulations revealed that the diffusivity of these three alcohols in H-ZSM-5 were significantly overestimated by Knudsen diffusion, which will complicate experimental efforts to develop a kinetic model for catalytic fast pyrolysis.
Application of Spatial Modulation to the Underwater Acoustic Communication Component of Autonomous Underwater Vehicle Networks (2005)

Abstract : There have been two fundamental advances in underwater acoustic communication in the last two decades. The first occurred in the early 1980's with the introduction of digital signaling techniques [1]. That facilitated both error correction and reverberation mitigation. The second advance has been the successful application of coherent signaling techniques [2]. That facilitated dramatic improvements in bandwidth efficiency and, hence, data rates. Since the introduction of coherent systems in the early 1990's, however, performance gains have been moderate and mostly attributed to important but largely technical algorithm improvements [3]. Spatial modulation offers the hope of yet another fundamental advance in performance by both enabling higher data rates and offering a strategy for improving performance in intersymbol interference (ISI) limited channels. The research conducted in this program seeks to define both the potential for spatial modulation in U.S. Navy underwater communication systems and develop practical prototypes suitable to meet U.S. Navy needs.
Gomori‐positive astrocytes: Biological properties and implications for neurologic and neuroendocrine disorders (1991)

Granule laden astrocytes exhibiting an affinity for chrome alum hematoxylin and aldehyde fuchsin (Gomori stains) have been described in the periventricular brain of all terrestrial vertebrate species examined to date including humans. The astrocytic inclusions are rich in sulfhydryl groups, emit an orange-red autofluorescence, and stain intensely with diaminobenzidine, a marker of endogenous peroxidase activity. The distinct autofluorescence pattern and the absence of neutral lipid, acid phosphatase, and beta-glucuronidase activity exclude lipofuscin or lysosomes as components of these astrocytic granules. The emission of orange-red autofluorescence and the nonenzymatic nature of the peroxidase activity implicate the presence of porphyrins and metalloporphyrins such as heme as major constituents of these cytoplasmic gliosomes. The role of Gomori-positive astrocytes under normal and pathologic conditions is incompletely understood. In vivo, numbers of astrocytic granules increase as a function of advancing age, in response to chronic estrogen stimulation, and following X-irradiation. In vitro, these cells accumulate with increasing time in culture and following exposure to the sulfhydryl agent, cysteamine. Gomori-positive astrocytes may supply heme to neurons for the synthesis of cytochromes, catalases, and other heme enzymes. They may play a role in photostimulation of sexual cyclicity, the promotion of neuritic development, the degradation of toxic lipoperoxides, and the metabolism of various neurotransmitters. Conversely, these cells may contribute to the pathogenesis of several neurologic and neuroendocrine disorders. Examples of the latter include a) augmentation of goldthioglucose neurotoxicity, b) induction of hypothalamic anovulation and reproductive failure, c) exacerbation of porphyric encephalopathy, and d) potentiation of parkinsonism and other free radical-related neurodegenerations.
Discrimination of malignant and normal kidney tissue with short wave infrared dispersive Raman spectroscopy (2018)

Renal mass biopsy is still controversial due to imperfect accuracy. Raman spectroscopy (RS) demonstrated promise as an in vivo real-time, nondestructive diagnostic tool in many malignancies. Short wave infrared (SWIR) RS has the potential to improve on previous RS systems for renal mass diagnosis. The aim of this study is to evaluate a SWIR RS system in differentiating normal and malignant renal samples. Measurements were acquired using a benchtop RS system with excitation wavelength at 1064 nm and an InGaAs array detector. Processed spectra were classified with a Bayesian machine learning algorithm, sparse multinomial logistic regression. Sensitivity and receiver operating characteristic curve analyses evaluated the classifier accuracy. Accuracy of the classifier was 92.5% with sensitivity and specificity of 95.8% and 88.8%, respectively. For posterior probability of malignant class assignment, the area under the ROC curve is 0.94 (95% confidence interval: 0.89-0.99, P < .001). SWIR RS accurately differentiated normal and malignant kidney tumors. RS has the potential to be used as a diagnostic tool in kidney cancer.