gebhart/patrepeval huggingface dataset:
Enhanced Survival of Autoepidermal-Allodermal Composite Grafts in Allosensitized Animals by Use of Silver-Nylon Dressings and Direct Current (1995)

SN dressings enhanced survival of meshed composite skin grafts.
Dimethylammonium: An A‐Site Cation for Modifying CsPbI3 (2020)

All‐inorganic perovskite materials are attractive alternatives to organic–inorganic perovskites because of their potential for higher thermal stability. Although CsPbI 3 is compositionally stable under elevated temperatures, the cubic perovskite α‐phase is thermodynamically stable only at &gt;330 °C and the low‐temperature perovskite γ‐phase is metastable and highly susceptible to non‐perovskite δ‐phase conversion in moisture. Many methods have been reported which show that the incorporation of acid (aqueous HI) or “HPbI 3 ”—recently shown to be dimethylammonium lead iodide (DMAPbI 3 ) —lowers the annealing temperature required to produce the black, perovskite phase of CsPbI 3 . Herein, the optical and crystallographic data presented show that dimethylammonium (DMA) can successfully incorporate as an A‐site cation to replace Cs in the CsPbI 3 perovskite material. This describes the stabilization and lower phase transition temperature reported in the literature when HI or HPbI 3 is used as precursors for CsPbI 3 . The Cs–DMA alloy only forms a pure‐phase material up to ≈25% DMA; at higher concentrations, the CsPbI 3 and DMAPbI 3 begin to phase segregate. These alloyed materials are more stable to moisture than neat CsPbI 3 , but do not represent a fully inorganic perovskite material.
Modal interferometer based on tapering single-mode-multimode-single-mode f iber structure by hydrogen flame (2012)

A modal interferometer is experimentally demonstrated based on tapering a single-mode-multimode-singlemode (SMS) fiber structure heated by hydrogen flame. The interference fringe begins to form when tapering length is 19.8 mm, and becomes regular and clear when the tapering length is longer and the tapered waist diameter is smaller. Annealing process is undertaken to achieve a high extension ratio of approximately 17 dB with free spectral range of 1.5 nm when the tapering length is 33 mm and the tapered waist diameter is approximately 5 m. The temperature and axial strain dependences of the tapered SMS structure are characterized, and the measured temperature and strain coefficients are +7 pm/ C and -9.536 pm/, respectively.
Abstract C144: A locked nucleic acid antisense oligonucleotode against androgen receptor, down-modulates target mRNA and causes antitumor effects in xenograft models of prostate cancer (2009)

Abstract Background: Androgen-deprivation therapies remain the first line treatment for prostate cancer. Despite an excellent initial response, most of these patients will succumb to the castration resistant form of the disease. Interestingly, even in the presence of castration levels of circulating androgens, these tumors are still dependent on a functional androgen receptor (AR). Therefore, inhibition of AR expression, rather than systemic androgen deprivation, may provide a novel strategy for treatment of advanced prostate cancer. We have developed a novel locked nucleic acid (LNA)-based antisense oligonucleotide (ASO), EZN-4176, that silence AR and is associated with tumor growth inhibition. Methods: Target mRNA and protein knockdown, growth inhibition, and apoptosis induction effects of EZN-4176 were evaluated by qRT-PCR, western blot analysis, ELISA, MTS assay, and caspase3/7 activity assay, respectively, in AR-positive cancer cell lines (LNCaP, 22RV1) or AR-negative cell line (PC3) in the presence or absence of lipofection (transfection reagent). In vivo, therapeutic efficacy of EZN-4176 was evaluated in AR-positive CWR22 (androgen dependent) and 22Rv1 (castration refractory) tumor models. Results: EZN-4176 resulted in potent down-modulation of AR mRNA or protein (IC50 &amp;lt;5 nM) when transfected in LNCaP or 22Rv1 cells. Consequently, cell growth was inhibited (IC50 &amp;lt; 10 nM), and caspase 3/7 activity was significantly increased. Additionally, the PSA mRNA and protein levels were significantly decreased after EZN-4176 treatment (IC50 &amp;lt; 5 nM). The biological effects of EZN-4176 were specific as the scrambled LNA-ASO did not down regulate target mRNA, nor were inhibitory effects on growth observed with EZN-4176 in an AR-negative cell line (PC3). In non-transfected cells, EZN-4176 but not the scrambled LNA-ASO down-regulated AR and inhibited the growth of DHT-induced LNCaP cells. In vivo, dose-dependent reduction of AR mRNA (up to 80%) in the liver was observed following intravenous administration of the EZN-4176. Additionally, EZN-4176 treatment dose-dependently inhibited AR (up to 40%), PSA (up to 85%) and TMPRSS2 (up to 50%), mRNA in, 22Rv1 or CWR22 tumor xenografts. In CWR22 tumor xenografts, EZN-4176 treatment also resulted in significant tumor growth inhibition (TGI) (∼55%) (similar to high-dose Casodex® [bicalutamide] treatment). TGI and mRNA knockdown effects in xenografts were specific as scrambled LNA-ASO resulted in no to insignificant response and EZN-4176 had no TGI in PC3 xenograft model. Cy5.5-labeled EZN-4176 was shown to localize in subcutaneous CWR22 or LnCaP tumor xenografts using xenogen imaging system. Conclusions: Our data suggest that EZN-4176 is a potent LNA-based ASO of AR that causes target down-modulation and TGI effects in vivo and hence may provide a novel strategy to treat advanced prostate cancer. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C144.
Improved Multitarget Tracking in the Presence of Port–Starboard Measurement Ambiguity Using the Bayes Factor (2022)

We consider an application where an unmanned underwater vehicle (UUV) equipped with an acoustic sensor seeks to estimate the location of surface ships using relative angle measurements to the ships. The estimation problem is challenging due to ships occasionally appearing and disappearing from the sensor's field of view. On occasion, poor geometry between the sensor and the ships, and port–starboard ambiguity that is inherent in the sensor contribute to the challenges in the estimation problem. The latter challenge arises because the sensor cannot distinguish between sound sources on its port and starboard side (port–starboard ambiguity). Therefore, every measurement is associated with two possible sound sources that map each relative angle to bearing projections on the port and starboard side of the UUV. We approach the problem of identifying the origin of sound sources (relative angle measurements) that are most likely to be of actual ships using Bayesian hypothesis testing. We propose an assignment method that uses the Bayes factor as the criteria to recursively associate measurements to the target that is most likely to be an actual ship and not a false target. The effectiveness of our approach is evaluated by comparing the performance of three multitarget tracking algorithms with and without our method. Performance is evaluated offline using sea-trial data captured by a UUV developed by the Naval Research Laboratory and Bluefin Robotics.
Tuning of Model Predictive Controllers Based on Hybrid Optimization (2022)

A tuning procedure for a model predictive controller (MPC) is presented for multi-input multi-output systems. The approach consists of two steps based on a hybrid method: the goal attainment method and a variable neighborhood search. In the first step, the weights of the MPC objective function are obtained, minimizing the square error between the closed-loop response of the internal controller model and a predefined desired reference trajectory. In the second step, the integer variables of the problem (prediction and control horizons) are obtained, minimizing the square error between the closed-loop response and an optimal trajectory, aiming a controller with low computational cost and good performance. The proposed method was tested in two benchmark processes using different MPC formulations, showing satisfactory results.
Investigation of Doping Type Conversion and Diffusion Length Extraction of Proton Implanted Silicon by EBIC (2013)

Electron beam induced current (EBIC) measurements were used to determine the doping type and to extract the diffusion length in proton implanted silicon wafers. This method makes it possible to distinguish between n-type and p-type at low carrier concentrations. Because of the defects caused by the implantation, the diffusion length is much smaller in the implanted than in the non-implanted regions.
Stochastic fair blue: a queue management algorithm for enforcing fairness (2002)

This paper describes and evaluates stochastic fair blue (SFB), a novel technique for enforcing fairness among a large number of rows. SFB scalably detects and rate-limits non-responsive flows through the use of a marking probability derived from the blue queue management algorithm and a Bloom (1970) filter. Using analysis and simulation, SFB is shown to effectively handle non-responsive flows using an extremely small amount of state information.
No Correlation Between Serum Markers and Early Functional Outcome After Contemporary THA (2016)

Level III, diagnostic study.
Site‐Specific Incorporation of ε‐N‐Crotonyllysine into Histones (2012)

A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification.
Effect of growth temperature on point defect density of unintentionally doped GaN grown by metalorganic chemical vapor deposition and hydride vapor phase epitaxy (1999)

We report on the investigation of the effect of growth temperature on point defect density of unintentionally doped GaN grown by atmospheric pressure metalorganic chemical vapor deposition and hydride vapor phase epitaxy. A correlation between photoluminescence (PL) spectra and the concentration of donors and acceptors in unintentionally doped GaN is presented. The effects of oxygen and native acceptors on the electrical and optical properties of GaN epitaxial layers are discussed and a classification of PL data is presented. On this basis we show that oxygen creates a shallow donor in GaN with an activation energy of about 23.5±1 meV. We determine that the concentration of native acceptors in GaN increases with an increase in growth temperature. These native acceptors, probably gallium antisites (GaN) and/or gallium vacancies (VGa), are nonradiative defects. We show that a second donor level in GaN has an activation energy of about 52.5±2.5 meV and produces a PL peak with an energy of about 3.45 eV at low temperatures. From Hall investigations we show that a third donor in GaN has an activation energy of 110±10 meV.
Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols (2012)

Robust and sensitive ELISPOT protocols are commonly applied concomitant with the development of new immunotherapeutics. Despite the knowledge that individual serum batches differ in their composition and may change properties over time, serum is still commonly used in immunologic assays. Commercially available serum batches are expensive, limited in quantity and need to be pretested for suitability in immunologic assays, which is a laborious process. The aim of this study was to test whether serum-free freezing media can lead to high cell viability and favorable performance across multiple ELISPOT assay protocols. Thirty-one laboratories from ten countries participated in a proficiency panel organized by the Cancer Immunotherapy Immunoguiding Program to test the influence of different freezing media on cell quality and immunologic function. Each center received peripheral blood mononuclear cells which were frozen in three different media. The participants were asked to quantify antigen-specific CD8+ T-cell responses against model antigens using their locally established IFN-gamma ELISPOT protocols. Self-made and commercially available serum-free freezing media led to higher cell viability and similar cell recovery after thawing and resting compared to freezing media supplemented with human serum. Furthermore, the test performance as determined by (1) background spot production, (2) replicate variation, (3) frequency of detected antigen-specific spots and (4) response detection rate was similar for serum and serum-free conditions. We conclude that defined and accessible serum-free freezing media should be recommended for freezing cells stored for subsequent ELISPOT analysis.
Direct Organocatalytic Polymerization from Cellulose Fibers (2005)

Abstract Summary: We have developed the first direct, organocatalytic, bulk ring‐opening polymerization (ROP) of ε ‐caprolactone ( ε ‐CL) with solid cotton and paper cellulose as the initiators. The mild ROPs were performed without solvent, and are operationally simple, inexpensive and environmentally benign. Organic‐acid‐catalyzed heterogeneous derivatization of cellulose provides a novel route to valuable cellulose‐based biocompatible nanomaterials. The furnished polymerization products were characterized by FTIR, 1 H and 13 C NMR spectroscopy, MALDI‐TOF mass spectrometry and electron microscopy. Organic acid‐catalyzed ring‐opening polymerization from cellulose fiber. image Organic acid‐catalyzed ring‐opening polymerization from cellulose fiber.
The Longest β-Unsubstituted Oligothiophenes and Their Self-Assembly in Solution (2010)

β-Unsubstituted oligothiophenes with up to 13 thiophene units are described. These represent the longest oligomers ever reported in this class. In solution, those compounds show a temperature- and concentration-dependent aggregation behavior. Absorption, fluorescence, dynamic light scattering, and cryo-transmission electron microscopy investigations reveal the formation of wormlike aggregates several hundred nanometers in length and ca. 5 nm in width.
Switched-capacitor neuromorphs with wide-range variable dynamics (1995)

The use of switched capacitors as wide-range, programmable resistive elements in spatially extensive artificial dendritic trees (ADT's) is described. We show that silicon neuro-morphs with ADT's can produce impulse responses that last millions of times longer than the initiating impulse and that dynamical responses are tunable in both shape and duration over a wide range. The switched-capacitor resistors forming a dendritic tree are shown indirectly to have a useful programmable resistance range between 500 KOmega and 1000 GOmega. Experimental results are presented that show variable impulse response functions, tunable frequency selectivity, and rate-invariance of spatiotemporal pattern responses.
TCP-SMO: extending TCP to support medium-scale multicast applications (2003)

Scalable reliable multicast protocols have been the focus of recent research, tackling the problem of efficient reliable data delivery to an arbitrarily large number of receivers. Yet, the common applications of multicast, such as multi-point file delivery, or video streaming from a media server, typically only involve a moderate number of receivers, such as a thousand or fewer. Moreover, because of the limited deployment of these specialized multicast protocols, it is common, when feasible, for applications to use multiple TCP connections instead, one for each receiver, to implement multi-point delivery, causing a significant demand on the transmission server and the downstream links. We describe a multicast extension to TCP, called single-source multicast optimization (SMO), that optimizes this case of multipoint delivery, providing the benefits of multicast together with the familiar features and API of TCP. Our results from experiments based on a Linux implementation and performed on a testbed show that TCP-SMO requires just a modest extension to the TCP implementation and provides scalable performance of multicast up to over a thousand receivers, thereby satisfying the common case requirements. In addition, used with TCP-RTM (real-time mode), TCP-SMO also supports real-time multimedia multicast applications well.
Consistency of weighted least-square estimators for parameter estimation problems based on binary measurements (2009)

In this paper, we present a new weighted least-squares (WLS) approach for parameter estimation based on binary data. Two WLS criteria are studied. We show that these two criteria do not have the same asymptotical behavior although they are closely related. Particularly, in the presence of noise, one of the criteria used for determining the system parameters provides an appropriate estimation, whereas the other one leads to an underestimation of the system parameters. These asymptotical results are illustrated by simulations in Gaussian and non-Gaussian contexts.
Visible radiation sliced image emission velocimeter interferometer fluctuation diagnostic (1999)

An instrument designed to measure k-filtered plasma fluctuations has been used to look at edge fluctuations in Alcator C-Mod tokamak plasmas. The instrument utilizes a sieve technique, whereby an optical image is split and filtered through two out-of-phase, striped transmission masks, and then imaged onto photodiode detectors. The difference signal is then digitized and analyzed to give the frequency characteristics of the fluctuations at a particular value of k, as determined by the wavelength of the mask stripes. Measurements have been made looking at the edge plasma with hydrogen Balmer-alpha filtering, and k both parallel and perpendicular to the magnetic field, with |k| in the range from 5 to 15 cm−1. Broad band (ν&amp;lt;500 kHz) fluctuations are seen for k perpendicular to B, and characteristics in ohmic and L-mode plasmas are described.
Direction-adaptive context modeling for sign coding in embedded wavelet image coder (2009)

The conventional embedded wavelet image coder exploiting the adjacent neighbors is limited to efficiently compress the sign coefficients, since the wavelet coefficients are highly correlated along the dominant image features, such as edges or contours. To solve the problem, in this paper, we propose the direction-adaptive sign context modeling by adaptively exploiting the neighbors suitable to the dominant image features. Experimental results show that the sign coding based on the proposed context modeling reduces the sign bits up to 5.5% compared to the conventional sign coding method.
Analysis and exploitation of non-linearities in passive RFID UHF systems (2014)

Powered by the exploding popularity of the Internet-of-Things (IoT), the demand for tagged devices with labels capable to ensure a reliable communication with added functions beyond the identification, such as sensing, location, health-care, among others, is growing rapidly. Certainly this growing is headed by the well-established Radio Frequency Identification (RFID) technology, and the use of wireless low-cost self-powered tags, in other words passive RFID tags, is the most widespread used alternative. In the constant evolution on this field, usually new software treatments are offered at the application layer with the objective to processing data to produce some new information. Further works aimed at improving the physical layer around the tag antenna miniaturization and matching techniques. So far, little or no work had been done on the exploitation of the communication channel, and certainly none has been done on the exploitation of the non-linear behavior of RFID chips.After presenting the RFID technology and phenomena produced by Radio Frequency (RF) non-linear devices, and leaning in some nearby works on the field, the core of this thesis starts by exposing two characterization platforms for the evaluation of non-linear phenomena presented during the reader-tag communication. One is specialized in radiating measurements considering the whole tag (antenna and chip) under test. The other is specialized in conducted measurements directly over RFID chips, allowing performing different parametric studies (power dependency, impedance, harmonic production, sensitivity). The characterization results show that harmonic signals generated from the passive RFID chip carry information.By exploiting the characterization results and to verify the hypothesis of exploitation of non-linearities in RFID, i.e. the use of harmonic signals, the research is pursued by designing, fabricating, and measuring four different configurations of RFID tags. The new RFID tags operate at the fundamental frequency in the UHF band and at its $3^{rd}$ harmonic in the microwave band. Antenna design policies, fabrication details, and parametric studies on the performance of the new prototypes are presented. The parametric study takes special care in the antenna structure, kind of chip used, received power, and read range.Finally, some alternatives approaches for the exploitation of non-linear effects generated by rectifying devices are presented. Some theoretical aspects and experimental results are discussed linking the passive RFID technology to the theories of Wireless Power Transfer (WPT) and Electromagnetic Energy Harvesting (EEH). The solution takes advantage of the non-linear nature of rectifying elements in order to maximize the RF-to-DC conversion efficiency of EEH devices and increase the read range of passive RFID tags. The solution triggers on the design of a RF multi-device system. The design procedure and tests consider three non-linear phenomena: (1) the impedance power dependency, (2) the harmonic production, and (3) the rectifying dependence on the RF waveform.
ARX spectrum disorders: making inroads into the molecular pathology (2010)

The Aristaless-related homeobox gene (ARX) is one of the most frequently mutated genes in a spectrum of X-chromosome phenotypes with intellectual disability (ID) as their cardinal feature. To date, close to 100 families and isolated cases have been reported to carry 44 different mutations, the majority of these (59%) being a result of polyalanine tract expansions. At least 10 well-defined clinical entities, including Ohtahara, Partington, and Proud syndromes, X-linked infantile spasms, X-linked lissencephaly with ambiguous genitalia, X-linked myoclonic epilepsy and nonsyndromic intellectual disability have been ascertained from among the patients with ARX mutations. The striking intra- and interfamilial pleiotropy together with genetic heterogeneity (same clinical entities associated with different ARX mutations) are becoming a hallmark of ARX mutations. Although males are predominantly affected, some mutations associated with malformation phenotypes in males also show a phenotype in carrier females. Recent progress in the study of the effect of ARX mutations through sophisticated animal (mice) and cellular models begins to provide crucial insights into the molecular function of ARX and associated molecular pathology, thus guiding future inquiries into therapeutic interventions.
Simultaneous and sequential same-arm measurements in the validation studies of automated blood pressure measuring devices (1996)

The oscillometric ambulatory blood pressure recorder Daypress 500 was validated according to the British Hypertension Society protocol. Both sequential and simultaneous measurements were used. Multiple regression analysis demonstrated a significant influence of subject pulse pressure and arm circumference on device-observer systolic pressure differences. Differences between observer consecutive readings were inversely related to heart rate. Device and observer blood pressure readings were closer at simultaneous than at sequential measurements. However, both kinds of measurement led to the same final evaluation (A for diastolic and B for systolic blood pressure), provided that the appropriate grading criteria were applied for each method.