gebhart/patrepeval huggingface dataset:
Dielectric Resonator Output Multiplexer for C-Band Satellite Applications (2005)

A 3-channel C-band manifold-coupled multiplexer using dielectric-loaded filters has demonstrated a viable approach for future satellite output multiplexer. The new multiplexer configuration utilizes dual- and triple-mode dielectric resonator filters coupled onto a ridged waveguide manifold. This design offers significant size and weight reduction while preserving the optimum electrical performance. It is therefore expected that this new output multiplexer design will be used for future C-band satellite systems.
HepaVac-101 first-in-man therapeutic cancer vaccine phase I/II clinical trial for hepatocellular carcinoma patients. (2018)

TPS3135 Background: HCC is the third leading cause of death from cancer globally with an extremely variable 5-year survival rate. The HepaVac-101 phase I/II, first-in-man, therapeutic cancer vaccine single-arm clinical trial is performed as part of the HepaVac project, funded by the European Commission’s 7th Framework Program under the Grant Agreement Nr. 602893 (www.hepavac.eu). The HepaVac-101 trial identification numbers are NCT03203005 (Clinical trials.gov) and 2015-003389-10 (EudraCT). and Methods: The therapeutic cancer vaccine IMA970A is a multi-peptide-based HCC vaccine composed of 16 newly discovered and overexpressed tumor-associated peptides (TUMAPs) directly identified from resected HCC tissues. Of these TUMAPs, 7 are restricted to HLA-A*02, 5 to HLA-A*24 and 4 to HLA class II. CV8102 is a novel RNA based immunostimulatory agent inducing a balanced Th1/Th2 immune response. A total of 40 patients with very early, early and intermediate stage of HCC are enrolled to be treated with a single pre-vaccination infusion of low-dose cyclophosphamide, followed by 9 intradermal vaccinations consisting of IMA970A plus CV8102. The study drugs are applied without concomitant anti-tumor therapy, in order to reduce risk of tumor recurrence/progression in patients having received all indicated standard treatments and without evidence of active disease. The primary endpoints of the HepaVac-101 clinical trial are safety, tolerability, and immunogenicity. Secondary/exploratory endpoints are additional immunological parameters in circulation, infiltrating T-lymphocytes in tumor tissue, biomarkers in blood and tissue, DFS/PFS and OS. Once safety of this vaccination approach has been established in the first 10 patients the addition of a checkpoint inhibitor will be considered. Suitable patients enrolled at Tuebingen are invited to participate in a trial extension investigating an actively personalized vaccine (APVAC). The HepaVac-101 trial is conducted in 6 centers located in 5 European countries. Five centers are actively recruiting patients. As of the time of abstract submission, 4 HCC patients have been screened for HLA haplotype and 1 is eligible for vaccination. Clinical trial information: NCT03203005.
Antibody-Toxin Conjugates (2002)

Soon after their discovery (1), monoclonal antibodies (MAbs) were exploited for their targeting specificity to deliver cytotoxic moieties, such as protein toxins, enzymes that activate prodrugs in situ, chemotherapeutic agents, and radionuclides. Many of this first-class generation of protein-protein conjugates, presented chemists with the challenge of designing a linker that is easily cleaved intracellularly but sufficiently stable in the blood circulation, and of developing purification procedures for obtaining highly active preparations suitable for clinical trials.
15 Gbit/in2 recording on a DWDD disc using a land/groove substrate with a red laser enabled by a side-wall-annealing process (2003)

We developed a side-wall-annealing technique for land/groove substrates. By applying this technique to our Domain Wall Displacement Detection (DWDD) Magneto-Optical (MO) recording stack formed on a land/groove substrate, even with an NA of 0.6 and a wavelength of 660 nm, we realized a density of 15 Gbit/in2 with a sufficiently wide recording tolerance. This density corresponds to a capacity of 4.7 GB on a Φ64 mm disc like Mini Disc.
Preparation of Nickel Nanoparticles in Water-in-Oil Microemulsion (2007)

Nickel nanoparticles were prepared by reduction of nickel-hydrazine complex with sodium borohydride (NaBH4) in water-in-oil (w/o) microemulsion of PVP/ethanol/toluene/water at 50C. It was investigated through SEM and TEM photographs that the nickel nanoparticles with a diameter 15~20nm were nearly monodispersed. By the analysis of XRD, the resulting particles were characterized to be pure crystalline nickel with a face-centered cubic structure. The results indicate that the size, shape and distribution of particles depend on the mole ratio of [water]/[PVP] and [NaBH4]/[Ni]. Also, it was found that particle size could be controlled by the kinds of surfactants.
Governing the Large Metropolis: What Is Governed and Not Governed? (2013)

In his lecture series, Patrick Le Galès contributes to the research agenda on governance that has been pioneered and developed at the MPIfG. He looks at three different dimensions in the governance of mobile societies. His third and final lecture in the series examines what is and isn’t being governed and uses the example of the metropolis to think about the limits of governance, the dark side of governance, and the discontinuities of governance.
In vivo Effects in Melanoma of ROCK Inhibition-Induced FasL Overexpression (2015)

Ectopic Fas-ligand (FasL) expression in tumor cells is responsible for both tumor escape through tumor counterattack of Fas-positive infiltrating lymphocytes and tumor rejection though inflammatory and immune responses. We have previously shown that RhoA GTPase and its effector ROCK negatively control FasL membrane expression in murine melanoma B16F10 cells. In this study, we found that B16F10 treatment with the ROCK inhibitor H1152 reduced melanoma development in vivo through FasL membrane overexpression. Although H1152 treatment did not reduce tumor growth in vitro, pretreatment of tumor cells with this inhibitor delayed tumor appearance, and slowed tumor growth in C57BL/6 immunocompetent mice. Thanks to the use of mice-bearing mutated Fas receptors (B6/lpr), we found that reduced tumor growth, observed in immunocompetent mice, was linked to FasL overexpression induced by H1152 treatment. Tumor growth analysis in immunosuppressed NUDE and IFN-γ-KO mice highlighted major roles for T lymphocytes and IFN-γ in the H1152-induced tumor growth reduction. Histological analyses of subcutaneous tumors, obtained from untreated versus H1152-treated B16F10 cells, showed that H1152 pretreatment induced a strong intratumoral infiltration of leukocytes. Cytofluorometric analysis showed that among these leukocytes, the number of activated CD8 lymphocytes was increased. Moreover, their antibody-induced depletion highlighted their main responsibility in tumor growth reduction. Subcutaneous tumor growth was also reduced by repeated intravenous injections of a clinical ROCK inhibitor, Fasudil. Finally, H1152-induced ROCK inhibition also reduced pulmonary metastasis implantation independently of T cell-mediated immune response. Altogether, our data suggest that ROCK inhibitors could become interesting pharmacological molecules for melanoma immunotherapy.
Searching for correlations between vibrational spectral features and structural parameters of silicate glass network (2020)

Abstract Infrared (IR) and Raman spectroscopic features of silicate glasses are often interpreted based on the analogy with those of smaller molecules, molecular clusters, or crystalline counterparts; this study tests the accuracy and validity of these widely cited peak assignment schemes by comparing vibrational spectral features with bond parameters of the glass network created by molecular dynamics (MD) simulations. A series of sodium silicate glasses with compositions of [Na 2 O] x [Al 2 O 3 ] 2 [SiO 2 ] 98− x with x = 7, 12, 17, and 22 were synthesized and analyzed with IR and Raman. A silica glass substrate and a crystalline quartz were also analyzed for comparison. Glass structures with the same compositions were generated with MD simulations using three types of potentials: fixed partial charge pairwise (Teter), partial diffuse charge potential (MGFF), and bond order‐based charge transfer potential (ReaxFF). The comparison of simulated and experimental IR spectra showed that, among these three potentials tested, ReaxFF reproduces the concentration dependence of spectral features closest to the experimentally observed trend. Thus, the bond length and angle distributions as well as Si– Q n species and ring size distributions of silica and sodium silicate glasses were obtained from ReaxFF‐MD simulations and further compared with the peak assignment or deconvolution schemes—which have been widely used since 1970s and 1980s—(a) correlation between the IR peak position in the Si–O stretch region (1050‐1120 cm −1 ) and the Si–O–Si bond angle; (b) deconvolution of the Raman bands in the Si–O stretch region with the Q n speciation; and (c) assignment of the Raman bands in the 420‐600 cm −1 region to the bending modes of (SiO) n rings with different sizes (typically, n = 3‐6). The comparisons showed that none of these widely used methods is congruent with the bond parameters or structures of silicate glass networks produced via ReaxFF‐MD simulations. This finding invokes that the adequacy of these spectral interpretation methods must be questioned. Alternative interpretations are proposed, which are to be tested independently in future studies.
Measurement of the capacity of MIMO systems in frequency-selective channels (2002)

We analyze the capacity of multiple-input-multiple-output (MIMO) systems in microcellular environments, taking into account the frequency selectivity of the wireless channels. We use a new data evaluation method that allows to evaluate the probability density function (PDF) of the capacity from a single measurement. We find that the frequency selectivity of the channel makes the PDF more peaked, and thus increases the outage capacity compared to the frequency-flat case. However, capacities are considerably lower than predicted for ideally decorrelated channels.
Imaging of Exocrine Pancreatic Function (1994)

Both ex vivo perfusion studies and dose-independent enhancement levels achieved seem to indicate a transport maximum in the pancreas for the iodinated weak organic acids studied.
Restoration of segregated, physiological neuronal connectivity by desynchronizing stimulation (2010)

The loss of segregation of neuronal signal processing pathways is an important hypothesis for explaining the origin of functional deficits as associated with Parkinson's disease. Here we use a modeling approach which is utilized to study the influence of deep brain stimulation on the restoration of segregated activity in the target structures. Besides the spontaneous activity of the target network, the model considers a weak sensory input mimicking signal processing tasks, electrical deep brain stimulation delivered through a standard DBS electrode and synaptic plasticity. We demonstrate that the sensory input is capable of inducing a modification of the network structure which results in segregated microcircuits if the network is initialized in the healthy, desynchronized state. Depending on the strength and coverage, the sensory input is capable of restoring the functional sub-circuits even if the network is initialized in the synchronized, pathological state. Weak coordinated reset stimulation, applied to a network featuring a loss of segregation caused by global synchronization, is able to restore the segregated activity and to truncate the pathological, synchronized activity.
Infrared Absorbance of Distributed-Size HgTe Quantum Dots Under Diffuse Reflectance (2022)

Colloidal quantum dots (CQDs) have various uses in photodetectors, solar cell devices and spectroscopic signal enhancement. In this paper, we synthesize mercury telluride (HgTe) CQDs and study the effect of the QDs size distribution on their infrared absorbance spectrum. The resulting dots are characterized using x-ray diffraction analysis and the size was found to be about 8.6 nm with a standard deviation of about 2 nm using high-resolution transmission electron microscope. The produced CQDs are optically characterized using Fourier transform infrared spectrometer in diffuse reflectance mode in the wavelength range from 3 to 11 μm. The absorption shows a wide absorption edge rather than a sharp feature. The measured data are fitted with a sum of a polynomial and five gaussian functions to extract the absorption lines of the QDs.
CORTICOTROPHIN RELEASING FACTOR: RESPONSES IN NORMAL SUBJECTS AND PATIENTS WITH DISORDERS OF THE HYPOTHALAMUS AND PITUITARY (1984)

Synthetic CRF-41 has been given to 43 patients with hypothalamic, pituitary or adrenal diseases and contrasted with the responses in 20 normal subjects. In the normal subjects the mean increment in serum cortisol (+/- SE) was 276 +/- 38 nmol/l; the increments showed a significant negative correlation with the basal serum cortisol levels (r = -0.56; P less than 0.02). The mean peak serum cortisol was 662 +/- 34 nmol/l and the mean peak corticosterone was 28.6 +/- 3.8 nmol/l. There was a significant positive correlation between the peak serum corticosterone and cortisol concentrations (r = 0.84; P less than 0.0001). Dexamethasone pretreatment abolished the rise in cortisol in response to CRF-41. The peak serum cortisol following CRF-41 was not significantly different between the normal subjects and those patients with pituitary disease who had normal cortisol responses to insulin-induced hypoglycaemia. However, in individual patients the peak cortisol levels induced by hypoglycaemia were greater than, but significantly correlated with, those induced by 100 micrograms of CRF-41. Seven patients were ACTH deficient in response to hypoglycaemia, and of these six responded normally to CRF-41. Only one of these patients had a lesion clearly originating in the hypothalamus; four had pituitary tumours with suprasellar extensions and the remaining patient had idiopathic GH and ACTH deficiency. Our data suggest that these patients have a functional defect of ACTH secretion due to the failure of CRF to reach the corticotroph. Of the four patients with pituitary-dependent Cushing's disease who were on no treatment at the time of testing, three showed an exaggerated and one a normal response to CRF-41. These normal or enhanced responses of hypercortisolaemic patients with Cushing's syndrome contrast with the complete inhibition of the responses to CRF-41 in normal subjects given dexamethasone. In the treated patients with Cushing's syndrome and normal serum cortisol levels, those with pituitary-dependent disease showed an enhanced ACTH response to CRF-41 as compared with the ectopic ACTH group, but there was some overlap between the two groups. Acromegalic patients did not show a GH response to CRF-41. We conclude that administration of CRF-41 is a safe new method for investigating disorders of the hypothalamo-pituitary axis.
Pykg2vec: A Python Library for Knowledge Graph Embedding (2019)

Pykg2vec is an open-source Python library for learning the representations of the entities and relations in knowledge graphs. Pykg2vec's flexible and modular software architecture currently implements 16 state-of-the-art knowledge graph embedding algorithms, and is designed to easily incorporate new algorithms. The goal of pykg2vec is to provide a practical and educational platform to accelerate research in knowledge graph representation learning. Pykg2vec is built on top of TensorFlow and Python's multiprocessing framework and provides modules for batch generation, Bayesian hyperparameter optimization, mean rank evaluation, embedding, and result visualization. Pykg2vec is released under the MIT License and is also available in the Python Package Index (PyPI). The source code of pykg2vec is available at https://github.com/Sujit-O/pykg2vec.
Profound Deficiency in Normal Circulating T Cells in Erythrodermic Cutaneous T-Cell Lymphoma (1994)

Patients with erythrodermic cutaneous T-cell lymphoma often have markedly depressed levels of normal blood T cells, to the range seen in advanced acquired immunodeficiency syndrome, and absolute numbers of malignant cells substantially exceed those recognized with less sensitive techniques.
Analysis of position-dependent light extraction of GaN-based LEDs (2005)

The light extraction efficiency of GaN-based LEDs as a function of the position of the light source over the active layer is studied. Several parameters, including chip dimensions, absorption coefficients and package are analyzed on the basis of a Monte-Carlo ray tracing simulation. The light extraction efficiency of a Thin-GaN LED is studied with respect to a sapphire-based LED, including the surface texture.
Polymerase Chain Reaction and a Biotin-Labeled DNA Probe for Detection of Infectious Bronchitis Virus in Chickens (1993)

Polymerase chain reaction (PCR) and a biotin-labeled DNA probe were used to amplify and detect the genome of infectious bronchitis virus (IBV) from tracheal swabs taken from chickens that were experimentally inoculated with the IBV Beaudette, Arkansas, and Gray strains. The viral genome was successfully detected by PCR and confirmed by dot-hybridization assay using a biotin-labeled DNA probe on days 1, 3, 9, and 14 after exposure. Direct electron microscopy (EM) analysis was used to compare the ability of the two tests to detect IBV from the same tracheal swab samples. The EM analysis did not detect IBV in four of eight necropsy groups that were positive using PCR and the biotin-labeled DNA probe. Although histopathological lesions were observed in the tracheas, no clinical signs or specific antibody response were observed in the birds. The virus was also detected in the allantoic fluid of embryonating chicken eggs that had been inoculated with field samples suspected to be IBV. The field samples were passed four to six times in embryonating eggs, and 10 of 17 samples were positive using PCR and the biotin-labeled probe.
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm (2007)

Sox2 is expressed in developing foregut endoderm, with highest levels in the future esophagus and anterior stomach. By contrast, Nkx2.1 (Titf1) is expressed ventrally, in the future trachea. In humans, heterozygosity for SOX2 is associated with anopthalmia-esophageal-genital syndrome (OMIM 600992), a condition including esophageal atresia (EA) and tracheoesophageal fistula (TEF), in which the trachea and esophagus fail to separate. Mouse embryos heterozygous for the null allele, Sox2(EGFP), appear normal. However, further reductions in Sox2, using Sox2(LP) and Sox2(COND) hypomorphic alleles, result in multiple abnormalities. Approximately 60% of Sox2(EGFP/COND) embryos have EA with distal TEF in which Sox2 is undetectable by immunohistochemistry or western blot. The mutant esophagus morphologically resembles the trachea, with ectopic expression of Nkx2.1, a columnar, ciliated epithelium, and very few p63(+) basal cells. By contrast, the abnormal foregut of Nkx2.1-null embryos expresses elevated Sox2 and p63, suggesting reciprocal regulation of Sox2 and Nkx2.1 during early dorsal/ventral foregut patterning. Organ culture experiments further suggest that FGF signaling from the ventral mesenchyme regulates Sox2 expression in the endoderm. In the 40% Sox2(EGFP/COND) embryos in which Sox2 levels are approximately 18% of wild type there is no TEF. However, the esophagus is still abnormal, with luminal mucus-producing cells, fewer p63(+) cells, and ectopic expression of genes normally expressed in glandular stomach and intestine. In all hypomorphic embryos the forestomach has an abnormal phenotype, with reduced keratinization, ectopic mucus cells and columnar epithelium. These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach.
Statistical methods for assessing treatment effects for observational studies. (2014)

Though randomized clinical (RCTs) trials are the gold standard for comparing treatments, they are often infeasible or exclude clinically important subjects, or generally represent an idealized medical setting rather than real practice. Observational data provide an opportunity to study practice-based evidence, but also present challenges for analysis. Traditional statistical methods which are suitable for RCTs may be inadequate for the observational studies. In this project, four of the most popular statistical methods for observational studies: ANCOVA, propensity score matching, regression with the propensity score as a covariate, and instrumental variables (IV) are investigated through application to MarketScan insurance claims data. Each of these methods is used to compare BMP versus autograft spinal surgeries for the outcomes length of stay, complications, and cost. Recommendations are made as to when each particular method may or may not be the optimal choice.
HGG-05. GALLIUM MALTOLATE AS TREATMENT IN PEDIATRIC GLIOMA (2019)

Pediatric high-grade gliomas are devastating central nervous system tumors for which effective therapies are lacking. These tumors become rapidly resistant to chemotherapy or radiation therapy. We have shown that adult glioblastomas (U87, D54, and glioblastoma stem cells) have a high requirement for iron to support their growth and viability and that the metallodrug gallium maltolate, GaM, inhibits the growth of glioblastoma in vitro and in vivo in an orthotopic brain tumor rat model. Ga interacts with critical iron-dependent proteins to inhibit mitochondrial function and iron-dependent activity of ribonucleotide reductase. We have initiated investigations to explore the potential antineoplastic activity of GaM in pediatric glioma. Five different pediatric glioma cells lines: 3 glioblastoma (SJ-GBM2, SF188, CHLA-200) and two ATRT (CHLA-266 and CHLA-02) cell lines were incubated for 48 – 96 hours with increasing concentrations of GaM and the effect on cell proliferation was determined by MTT and PE assays. In CHLA-200, SF188, and SJ-GBM2 cells, the IC50 of GaM was 48.4 µM, 73.9 µM and 100 µM, respectively, while in CHLA-266 ATRT cells the IC50 was 16.3 µM after a 96h incubation of cells with GaM. Annexin V staining showed GaM, induces apoptosis in GBM and ATRT cells. Since the majority of glioma patients receive radiation therapy as their first line of treatment, we examined the effects of GaM on cell proliferation after glioma cell lines had been exposed to a single radiation dose of 10 GY. These studies indicate an additive effective of GaM on radiation-induced cell death. Our study is the first to show that GaM inhibits the growth of pediatric gliomas with varying efficacy. Further studies are in progress to investigate differences in iron metabolism among the pediatric glioma cells, drug combinations of GaM with other standard therapeutic agents, and the molecular basis for drug resistance.
Risk of hemorrhagic gastropathy associated with colonoscopy bowel preparation using oral sodium phosphate solution (2010)

Oral NaP bowel preparation for colonoscopy was associated with hemorrhagic gastropathy.