gebhart/patrepeval huggingface dataset:
Effect of dietary protein on calpastatin in canine skeletal muscle1 (2003)

The cysteine proteinases, mu- and m-calpain, along with their inhibitor, calpastatin, have been hypothesized to play a role in skeletal muscle protein degradation. Because nutrition has previously been shown to influence the expression of calpastatin, the working hypothesis of this study was that the quantity and source of dietary protein could influence regulation of the calpain system in muscle. The objectives to support this hypothesis were to determine the effects of dietary protein (amount and source) on the expression of calpastatin in canine skeletal muscle. This study comprised eight diets with seven dogs per diet. A biopsy was taken from the biceps femoris of all 56 dogs before and after 10 wk on their respective diets. This experimental design allowed examination of change within individual dogs. Diets 1 to 4 contained 12% total protein derived from chicken and/or corn gluten meal in ratios of 100:0, 67:33, 33:67, and 0:100%, respectively. Diets 5 to 8 contained 28% total protein with protein sources and ratios identical to Diets 1 to 4. Differences in calpastatin were examined qualitatively using SDS-PAGE and immunoblotting, and semiquantitatively with densitometric analyses. The majority of the calpastatin blots showed three distinct calpastatin bands, the uppermost appearing at approximately 110 kDa. Diet 5 (28% CP, 100% chicken) resulted in an increase in the expression of the 110-kDa calpastatin band compared with the other two lower molecular weight bands in the same samples. Muscle from dogs fed Diet 5 showed greater increase in (P < 0.05) calpastatin intensity of the topmost band than those fed Diet 8 (0:100; chicken:corn gluten meal). Diet 5 (100:0; chicken:corn gluten meal) showed greater total calpastatin intensity than Diet 8 (0:100; chicken:corn gluten meal). These data suggest that dogs fed a diet containing a higher total percentage of chicken protein may have a greater potential to regulate calpain-mediated degradation of muscle protein than dogs fed diets containing corn gluten meal.
Adaptive Two-Dimensional Neighborhood Sensitivity Control By A One-Dimensional Process (1988)

The adaptive characteristics of the retina, which operates over an extremely wide range of light intensities, exceed by far the performance of serially accessed sensors such as vidicons or C.C.D.&apos;s. The latter, operating over the entire optical field (or sampled grid) as a single neighborhood, are easily cut off by small areas of high intensity, resulting in the well known effect of &quot;obscured images&quot;. Implementation of the biological solution of two-dimensional neighborhood processing, in which sensitivity at a given point is determined by the surrounding (receptive) field, would be the best solution. This approach requires, however, a new generation of still unavailable detector arrays with random access, neighborhood processing and local sensitivity feedback. The approach proposed in this paper is devised for sequentially accessed detectors/detector-arrays with one-dimensional processing, in which a Peano-Hilbert-like scan-path acquires visual data, thereby preserving a compact two-dimensional neighborhood relation. Neighborhood suppression is controlled by the expected value of a one-dimensional string, mapped onto the relevant two-dimensional neighborhood and subtracted, in turn, from the intensity of the delayed central element of the confined data string.
Rapid determination of urinary globotriaosylceramide isoform profiles by electrospray ionization mass spectrometry using stearoyl‐d 35 ‐globotriaosylceramide as internal standard (2005)

Globotriaosylceramide is a neutral glycolipid containing the trihexoside Gal(alpha1-4)Gal(ss1-4)Glc(ss1-1') covalently bound to N-acylsphingosine. It was identified as the main storage substance in the kidney of patients with Fabry disease, an X-linked deficiency of lysosomal alpha-galactosidase A which can significantly be ameliorated by enzyme replacement therapy. Unlike hemizygote males, affected heterozygote females cannot be identified by enzyme assays and therefore may remain untreated. A quantitation of urinary globotriaosylceramides was proposed as an alternative method for their diagnosis. However, the required studies on physiological and pathological variations in the excretion of trihexosides so far have been prevented by a lack of suitable methods. A validated, robust and quick high-throughput method for the quantitative analysis of globotriaosylceramide isoforms using stable-isotope-dilution/internal standardization and electrospray ionization mass spectrometry (ESI-MS) was developed. An internal standard, stearoyl-d35-globotriaosylceramide, was synthesized by enzymatic coupling of d35-stearic acid to the corresponding lyso-ceramidetrihexoside. Glycolipid isoforms of high purity were obtained from a 5-mL urine portion by extraction on C18 solid-phase columns and a novel washing protocol. ESI-MS analysis was performed in full and neutral loss scan modes. Urinary trihexosyl- and some of the di- and monohexosylceramide isoforms can be quantified within a single experiment. All glycolipid isoforms were above detection limit in healthy male and female subjects (n = 63). Prominent elevations of tetracosanoyl-(C24:0 plus C24:1)-globotriaosylceramides were found in urines from female (>2.5-fold above normals) or male Fabry patients (>5.8-fold above normals), but not among controls. Globotriaosylceramide isoforms shall now be analyzed in Fabry patients, non-genetic kidney disease and healthy subjects to define the conditions for a safe diagnosis of heterozygotes.
Evaluation of Box Beam Stiffening of Unanchored Temporary Concrete Barriers (2008)

Temporary of concrete barrier (TCB) systems that are not pinned into the pavement can be displaced during an impact and can result in workers being crushed between the barrier and objects within the workspace. Alternatively, the barrier could be moved far enough to fall off of the paved surface and onto workers in an excavation, below a bridge, or onto traffic under the bridge. The process for drilling holes in a bridge deck to anchor temporary concrete barriers is time-consuming, costly, and may ultimately result in damage to the bridge. Thus, a means for reducing the deflection of the barrier system is necessary and without the use of anchoring the barrier sections to the underlying pavements with pins, rods or bolts. The primary objective of this study was to evaluate the potential for reducing barrier deflections through the use of box beams stiffening on New York State’s TCB. The secondary objective of the study was to evaluate stiffened and unstiffened versions of New York State’s temporary concrete barrier system according to the Test Level 3 (TL-3) criteria set forth in the currently proposed Update to NCHRP Report No. 350.
Utility of B-type natriuretic peptide in children (2007)

BNP is a useful, prognostically valuable method in children to monitor ventricular function. BNP levels reflect the severity of the impairment of systemic RV function in Senning patients in whom a complex RV geometry is present causing the assessment of RV function more difficult, so we recommend BNP measurements as a longitudinal test in this patient group.
Experimental observation of quantum correlations between measurement errors using entangled photon pairs as a probe (2018)

In order to evaluate a quantum correlation between two measurement errors in a joint measurement, we performed correlation measurements of entangled photon pairs with two identified joint measurements, where two different non-commuting polarizations are jointly measured for each photon. The joint measurements were realized by filtering the polarization oriented the direction, which is halfway in two observables. The experimentally observed correlations corresponded to the ideal correlations expected for the entangled state, except for the correlation between the products of the two non-commuting polarizations. This result exceeds the limits that apply to classical error statistics and suggests that the correlation between the measurement errors in each local measurement is imaginary.
Transcriptomic recurrence score improves recurrence prediction for surgically treated patients with intermediate‐risk clear cell kidney cancer (2022)

Abstract Background Risk stratification of kidney cancer patients after nephrectomy may tailor surveillance intensity and selection for adjuvant therapy. Transcriptomic approaches are effective in predicting recurrence, but whether they add value to clinicopathologic models remains unclear. Methods Data from patients with clear cell renal cell carcinoma (ccRCC) was downloaded from The Cancer Genome Atlas. Clinicopathologic variables were used to calculate SSIGN (stage, size, grade, and necrosis) scores. The 16 gene recurrence score (RS) signature was generated using RNA‐seq data. Transcriptomic risk groups were calculated using the original thresholds. SSIGN groups were divided into low, intermediate, and high risk. Disease‐free status was the primary endpoint assessed. Results SSIGN and RS were calculated for 428 patients with non‐metastatic ccRCC. SSIGN low‐, intermediate‐, and high‐risk groups demonstrated 2.7%, 15.2%, and 27.5%, 3‐year recurrence risk, respectively. On multivariable analysis, the RS was associated with disease‐free status (sub‐distribution hazard ratio (sHR) 1.43 per 25 RS [95% CI (1.00–1.43)], p = 0.05). By risk groups, RS further risk stratified the SSIGN intermediate‐risk group (sHR 2.22 [95% CI 1.10–4.50], p = 0.03). SSIGN intermediate‐risk patients with low and high RS had a 3‐year recurrence rate of 8.0% and 25.2%, respectively. Within this risk group, the area under the curve (AUC) at 3 years was 0.69 for SSIGN, 0.74 for RS, and 0.78 for their combination. Conclusions Transcriptomic recurrence scores improve risk prediction even when controlling for clinicopathologic factors. Utility may be best suited for intermediate‐risk patients who have heterogeneous outcomes and further refinement for clinical utility is warranted.
Artifacts Availability & Reproducibility (VLDB 2021 Round Table) (2022)

In the last few years, SIGMOD and VLDB have intensified efforts to encourage, facilitate, and establish reproducibility as a key process for accepted research papers, awarding them with the Reproducibility badge. In addition, complementary efforts have focused on increasing the sharing of accompanying artifacts of published work (code, scripts, data), independently of reproducibility, awarding them the Artifacts Available badge. In this short note, we summarize the discussion of a panel held during VLDB 2021 titled "Artifacts, Availability &amp; Reproducibility". We first present a more detailed summary of the recent efforts. Then, we present the discussion and the contributed key points that were made, aiming to assess the reproducibility of data management research and to propose changes moving forward.
The petrophysical basis for shallow-water flow prediction using multicomponent seismic data (2001)

Physical properties of shallow-water flow (SWF) sands differ from most reservoir and seal rocks studied for petroleum purposes. These materials exist near the transition zone between rocks and sediments. Our investigations, the subject of this article, suggest that physical properties of SWF sands are amenable to a prediction methodology that uses high-resolution multicomponent seismic data.
Nonchromatographic Solid‐Phase Purification of Enantiomers (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.
Travelling ultrasound promotes vasculogenesis of three‐dimensional‐monocultured human umbilical vein endothelial cells (2021)

To generate three-dimensional tissue in vitro, promoting vasculogenesis in cell aggregates is an important factor. Here, we found that ultrasound promoted vasculogenesis of human umbilical vein endothelial cells (HUVECs). Promotion of HUVEC network formation and lumen formation were observed using our method. In addition to morphological evaluations, protein expression was quantified by western blot assays. As a result, expression of proteins related to vasculogenesis and the response to mechanical stress on cells was enhanced by exposure to ultrasound. Although several previous studies have shown that ultrasound may promote vasculogenesis, the effect of ultrasound was unclear because of unregulated ultrasound, the complex culture environment, or two-dimensional-cultured HUVECs that cannot form a lumen structure. In this study, regulated ultrasound was propagated on three-dimensional-monocultured HUVECs, which clarified the effect of ultrasound on vasculogenesis. We believe this finding may be an innovation in the tissue engineering field.
Enabling GPU and Many-Core Systems in Heterogeneous HPC Environments Using Memory Considerations (2010)

Increasing the utilization of many-core systems has been one of the forefront topics these last years. Although many-cores architectures were merely theoretical models few years ago, they have become an important part of the high performance computing market. The semiconductor industry has developed Graphical Processing Units (GPU) systems that provide access to many cores (i.e: Larrabee, Fermi or Tesla) that can be used for General Purpose (GP) computing. In this paper, we propose and evaluate a scheduling strategy for GPU and many-core architectures for HPC environments. Specifically, our strategy is a variant of the backfilling scheduling policy with resource sharing considerations. We propose a scheduling strategy that considers the differences between GP processors and GPU computing elements in terms of computational capacity and memory bandwidth. To do this, our approach uses a resource model that predicts how shared resources are used in both GP and GPU/many-core elements. Furthermore, it considers the differences between these elements in terms of performance. First, it models their differences in terms of computational power and how they share the access to the node's memory bandwidth. Second, it characterizes how the processes are allocated to the GPU. Using this resource model, we design the Power Aware resource selection policy, which we combine with the LessConsume scheduling policy. Our strategy tries to allocate jobs aiming at reducing the memory contention and the energy consumption. Results show that the scheduling strategies proposed in this work are able to save over 40% of energy and improve the system performance up to 30% with respect to traditional backfilling strategies.
A Single Pulse Charge Pumping Technique for Fast Measurements of Interface States (2011)

Characterizing interface states is a key task, and it typically takes seconds when conventional techniques, such as charge pumping (CP), are used. The stress-induced degradation can recover substantially during this time, and there is a need to improve the measurement speed. The central task of this work is to reduce the measurement time for interface states from seconds to microseconds to minimize the recovery. A fast single pulse CP (SPCP) technique is developed. By exploring the differences in the transient currents corresponding to the two edges of the gate pulse, the net charges pumped into devices can be obtained, and their saturation level is used to evaluate interface states. Unlike the conventional CP (CCP) method, the contribution of currents during the plateaus of gate pulse is excluded for SPCP, making it less vulnerable to the interferences of gate leakage and defects within dielectrics. For the first time, the SPCP allows the recovery of interface states being monitored with a time resolution in microseconds. The results show that the recovery of stress-induced interface states is substantial within 100 μs, which would be missed if the CCP were used.
Abstract 15943: Phenotypes of Cardiogenic Shock Associated With Increasing In-Hospital Mortality: A Report From The National Cardiogenic Shock Working Group Registry (2019)

Introduction: Cardiogenic shock (CS) mortality remains prohibitively high. A major limitation in the field has been the lack of large registries that include hemodynamic data for analysis. The Nati...
Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. (1989)

Screening of new insecticidal and acaricidal antibiotics was carried out with reference to anti-brine shrimp activity from actinomycete strains isolated from marine environments. Of 200 actinomycete isolates, one isolate was found to produce a new substance, altemicidin. The strain was isolated from sea mud collected at Gamo, Miyagi Prefecture, Japan, and identified as Streptomyces sioyaensis SA-1758. Altemicidin was purified by Diaion CHP-20P and Sephadex LH-20 column chromatographies. The molecular formula was determined as C13H20N4O7S by elemental analysis, MS and 13C NMR spectrum. Altemicidin showed not only acaricidal activity but also antitumor activity. The compound showed no antimicrobial activity except the inhibitory activity to Xanthomonas strains.
Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection (2007)

The analysis of bone marrow chimeric mice reveals a dual role of CD36 in P. berghei ANKA infection. Expression of CD36 in haematopoietic cells, most likely macrophages and dendritic cells, has a beneficial effect that is masked in normal mice by adverse effects of CD36 expression in non-haematopoietic cells, most likely endothelial cells.
Noncanonical Role of the PDZ4 Domain of the Adaptor Protein PDZK1 in the Regulation of the Hepatic High Density Lipoprotein Receptor Scavenger Receptor Class B, Type I (SR-BI) (2013)

The four PDZ (PDZ1 to PDZ4) domain-containing adaptor protein PDZK1 controls the expression, localization, and function of the HDL receptor scavenger receptor class B, type I (SR-BI), in hepatocytes in vivo. This control depends on both the PDZ4 domain and the binding of SR-BI's cytoplasmic C terminus to the canonical peptide-binding sites of either the PDZ1 or PDZ3 domain (no binding to PDZ2 or PDZ4). Using transgenic mice expressing in the liver domain deletion (ΔPDZ2 or ΔPDZ3), domain replacement (PDZ2→1), or target peptide binding-negative (PDZ4(G389P)) mutants of PDZK1, we found that neither PDZ2 nor PDZ3 nor the canonical target peptide binding activity of PDZ4 were necessary for hepatic SR-BI regulatory activity. Immunohistochemical studies established that the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI. Analytical ultracentrifugation and hydrogen deuterium exchange mass spectrometry suggested that the requirement of PDZ4 for localization and SR-BI regulation is not due to PDZ4-mediated oligomerization or induction of conformational changes in the PDZ123 portion of PDZK1. However, surface plasmon resonance analysis showed that PDZ4, but not the other PDZ domains, can bind vesicles that mimic the plasma membrane. Thus, PDZ4 may potentiate PDZK1's regulation of SR-BI by promoting its lipid-mediated attachment to the cytoplasmic membrane. Our results show that not all of the PDZ domains of a multi-PDZ domain-containing adaptor protein are required for its biological activities and that both canonical target peptide binding and noncanonical (peptide binding-independent) capacities of PDZ domains may be employed by a single such adaptor for optimal in vivo activity.
Improvement of Picture Quality for NTSC and PAL Systems by Digital Signal Processing (1985)

We have developed an intrafield picture quality improvement system within the existing TV standards.
Unusual surface reliefs from photoinduced creeping and aggregation behavior of azopolymer (2008)

We report the spontaneous formation of unusual surface reliefs, in which two sets of sinusoidal gratings were hierarchically structured, merely by single-step holographic inscription on amorphous azopolymer films. By monitoring of growth behavior of surface reliefs during holographic inscription, we found that the formation of additional grating is caused by the creeping and resulting aggregation of dome structures. Our direct observation of creeping and aggregation behavior is expected to contribute to enhancing the understanding of unusual surface reliefs, and also in fabricating complex surface reliefs.
Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice (2017)

Together, our data show that short-term blockade of IL-7Rα induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice. These changes appear to have long-lasting effects by delaying or preventing type 1 diabetes incidence. Hence, our study provides further support for using anti-IL-7Rα antibodies to modulate autoreactive T cell responses.
Control of Chocolate Spot in Potato Tubers by Foliar Spray with 2-Chloroethylphosphonic Acid (1971)

Abstract Incidence of chocolate spot, known also as internal brown spot, in tubers of the ‘Arran Banner’ cultivar can reach as high as 60% (Fig. 1). This cultivar is widely grown in the Beqa'a plain of Lebanon for its high yield and good storage life. Other cultivars grown elsewhere in potato producing areas of the world are also seriously damaged by this physiological disease. Control in ‘Arran Banner’ in Lebanon was obtained by foliar sprays with 2-chloroethylphosphonic acid (ethephon)4 using rates ranging from 200-600 ppm (Table 1).
Evaluation of a measure taken for controlling subsidence for a large-scale double deck tunnel at shallow depth (2020)

The Ohme tunnel is a large scale tunnel at a shallow depth in an unconsolidated ground in urban area. Horizontal jet grouting is used as a subsidence countermeasure. The effect of horizontal jet grouting is verified by field measurement, in-situ tests and finite element analyses. The difference of subsidence of the ground by field measurement between the section which adopts a horizontal jet grouting and those which does not adopt one become 20mm. Then, it is confirmed by the nonlinear back analysis considering the anisotropic damage that the ground around the tunnel maintains an elastic state. As the results of the above, this paper shows the horizontal jet grouting is very effective in the subsidence control of ground for tunnel excavation.
Multicycle High-Dose Chemotherapy and Filgrastim-Mobilized Peripheral-Blood Progenitor Cells in Women With High-Risk Stage II or III Breast Cancer: Five-Year Follow-Up (1999)

Multiple cycles of dose-intensive, nonablative chemotherapy is a feasible and safe approach. Disease control and survival are similar to those in other studies of myeloablative chemotherapy in poor-prognosis breast cancer. The regimen is being evaluated in a randomized trial of the International Breast Cancer Study Group.