gebhart/patrepeval huggingface dataset:
PVA/Dextran hydrogel patches as delivery system of antioxidant astaxanthin: a cardiovascular approach (2017)

After myocardial infarction, the heart's mechanical properties and its intrinsic capability to recover are compromised. To improve this recovery, several groups have developed cardiac patches based on different biomaterials strategies. Here, we developed polyvinylalcohol/dextran (PVA/Dex) elastic hydrogel patches, obtained through the freeze thawing (FT) process, with the aim to deliver locally a potent natural antioxidant molecule, astaxanthin, and to assist the heart's response against the generated myofibril stress. Extensive rheological and dynamo-mechanical characterization of the effect of the PVA molecular weight, number of freeze-thawing cycles and Dex addition on the mechanical properties of the resulting hydrogels, were carried out. Hydrogel systems based on PVA 145 kDa and PVA 47 kDa blended with Dex 40 kDa, were chosen as the most promising candidates for this application. In order to improve astaxanthin solubility, an inclusion system using hydroxypropyl-β-cyclodextrin was prepared. This system was posteriorly loaded within the PVA/Dex hydrogels. PVA145/Dex 1FT and PVA47/Dex 3FT showed the best rheological and mechanical properties when compared to the other studied systems; environmental scanning electron microscope and confocal imaging evidenced a porous structure of the hydrogels allowing astaxanthin release. In vitro cellular behavior was analyzed after 24 h of contact with astaxanthin-loaded hydrogels. In vivo subcutaneous biocompatibility was performed in rats using PVA145/Dex 1FT, as the best compromise between mechanical support and astaxanthin delivery. Finally, ex vivo and in vivo experiments showed good mechanical and compatibility properties of this hydrogel. The obtained results showed that the studied materials have a potential to be used as myocardial patches to assist infarcted heart mechanical function and to reduce oxidative stress by the in situ release of astaxanthin.
Millimeter-wave antenna using metamaterial ELC resonators on electro-optics substrate (2015)

We propose and present millimeter-wave antennas using metamaterial ELC resonators on electro-optic substrates for wireless millimeter-wave receivers and optical modulators. Analysis for the antenna characteristics of the device are discussed at millimeter-wave frequency of 100GHz.
Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection (2022)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused an ongoing global health crisis. Here, we present as a vaccine candidate synthetic SARS-CoV-2 spike (S) glycoprotein-coated lipid vesicles that resemble virus-like particles. Soluble S glycoprotein trimer stabilization by formaldehyde cross-linking introduces two major inter-protomer cross-links that keep all receptor-binding domains in the "down" conformation. Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4<sup>+</sup>-biased T cell responses. Although anti-receptor-binding domain (RBD)-specific antibody responses are initially predominant, the third immunization boosts significant non-RBD antibody titers. Challenging vaccinated animals with SARS-CoV-2 shows a complete protection through sterilizing immunity, which correlates with the presence of nasopharyngeal anti-S immunoglobulin G (IgG) and IgA titers. Thus, the S-LV approach is an efficient and safe vaccine candidate based on a proven classical approach for further development and clinical testing.
Ray Tracing Structured AMR Data Using ExaBricks (2020)

Structured Adaptive Mesh Refinement (Structured AMR) enables simulations to adapt the domain resolution to save computation and storage, and has become one of the dominant data representations used by scientific simulations; however, efficiently rendering such data remains a challenge. We present an efficient approach for volume- and iso-surface ray tracing of Structured AMR data on GPU-equipped workstations, using a combination of two different data structures. Together, these data structures allow a ray tracing based renderer to quickly determine which segments along the ray need to be integrated and at what frequency, while also providing quick access to all data values required for a smooth sample reconstruction kernel. Our method makes use of the RTX ray tracing hardware for surface rendering, ray marching, space skipping, and adaptive sampling; and allows for interactive changes to the transfer function and implicit iso-surfacing thresholds. We demonstrate that our method achieves high performance with little memory overhead, enabling interactive high quality rendering of complex AMR data sets on individual GPU workstations.
Telemedicine in Spine Surgery: Global Perspectives and Practices (2021)

Our study noted significant geographical differences in the rate of telemedicine adoption and the platform of telemedicine utilized. The results suggest a significant increase in telemedicine utilization, particularly in North America. Spine surgeons found telemedicine feasible for imaging review, initial visits, and follow-up visits although the vast majority still preferred at least one in-person preoperative visit.
The Optimum Error Nonlinearity In Lms Adaptation With An Independent And Identically Distributed Input (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Re: Telomere Length Influences Cancer Cell Differentiation In Vivo (2013)

No AccessJournal of UrologyInvestigative Urology1 Mar 2014Re: Telomere Length Influences Cancer Cell Differentiation In Vivo Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.11.038AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Telomere Length Influences Cancer Cell Differentiation In Vivo." The Journal of Urology, 191(3), pp. 867–868 © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 191Issue 3March 2014Page: 867-868Supplementary Materials Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.Metrics Author Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Sampling Depth Controlled by Accelerating Voltage in a Low Voltage SEM (1997)

Abstract A fundamental new pathway to a basic understanding of nanostructured composite thin films has been recently afforded by advances in both high brightness field emission electron source and electron optics in the SEM. The key advantages of controlling the incident electron beam at low energies (&amp;lt; 5 keV) for surface imaging has been largely focused on goals such as the reduction of sample charging and minimization of macroscopic radiation damage. In this paper, we present a new opportunity to obtain sampling depth information by controlling the incident electron beam energy. One of the major factors which determines the contrast seen in SEM images is the interaction of the incident electron beam with the solid. As a result of this interaction, the secondary electron yield is proportional to the stopping power of the electron as described by the Bethe penetration depth,where dE/dl is the stopping power of incident electron with energy Einc and Emin is some suitable lower energy limit for the interaction.
Patientenspezifische Annuloplastieringe für die Mitralklappenrekonstruktion (2012)

Es wird ein Verfahren zur Herstellung patientenspezifischer Annuloplastieringe vorgestellt. Der Mitralklappenannulus wird aus Computertomographiebildern modelliert. Eine optimale Ringgeometrie wird interaktiv erstellt. Die Ringe werden mittels Selective Laser Melting aus einer Titanlegierung hergestellt. Im Tierversuch wurde die Machbarkeit des Verfahrens überprüft. Mit patientenspezifisch geformten Annuloplastieringe für die Mitralklappenrekonstruktion könnten die chirurgische Therapie besser an die individuelle Anatomie und Pathologie angepasst werden.
Effect of induced hypercapnia on anaerobic metabolic rate of anoxic musk turtles (1988)

To evaluate the possible effect of induced hypercapnia on anaerobic metabolic rate during anoxia, musk turtles (Sternotherus odoratus) were submerged in N2-equilibrated water at 10 degrees C for 3 days either with (anoxic hypercapnic) or without (anoxic normocapnic) elevated aquatic PCO2 (30-40 Torr). Control animals had access to air at 10 degrees C. Plasma [lactate] was significantly higher (P less than 0.01) in the normocapnic [59.4 +/- 7.4 (SD) mM; n = 22] than in the hypercapnic (47.4 +/- 8.5 mM; n = 19) anoxic turtles, although the hypercapnic turtles had lower blood pH (P less than 0.05). Plasma ion concentrations (Na, K, Cl, Ca, and Mg), however, were no different in the two groups, although all values other than Na were different from control. In some of the animals, [lactate] and [glycogen] (per g wet wt) of skeletal muscle, heart, and liver were measured in addition to blood acid-base values and lactate. Tissue lactates, although significantly elevated from control, and glycogens, although (with the exception of skeletal muscle) significantly reduced from control, were no different in the two anoxic groups. We suggest that these tissue data are more valid indicators of anaerobic metabolic rate than is plasma lactate and therefore conclude that induced hypercapnia does not significantly depress anaerobiosis in musk turtles at 10 degrees C.
Acid-Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate (2021)

A trifluoroacetic-acid-mediated desulfurilative sulfonylthiolation of arenes using <i>SS</i>-morpholino dithiosulfonate is described. This system is based on selective activation of the morpholino group over the tosyl group of the doubly transformable sulfur surrogate. Mechanistic studies suggested that the reaction proceeds through electrophilic aromatic substitution followed by sulfur extrusion. The wide substrate scope of this reaction and the transformability of the resulting thiosulfonates enable expeditious access to divergent multifunctionalized sulfides.
ScanSAT (2019)

While financially advantageous, outsourcing key steps such as testing to potentially untrusted Outsourced Semiconductor Assembly and Test (OSAT) companies may pose a risk of compromising on-chip assets. Obfuscation of scan chains is a technique that hides the actual scan data from the untrusted testers; logic inserted between the scan cells, driven by a secret key, hide the transformation functions between the scan-in stimulus (scan-out response) and the delivered scan pattern (captured response). In this paper, we propose ScanSAT: an attack that transforms a scan obfuscated circuit to its logic-locked version and applies a variant of the Boolean satisfiability (SAT) based attack, thereby extracting the secret key. Our empirical results demonstrate that ScanSAT can easily break naive scan obfuscation techniques using only three or fewer attack iterations even for large key sizes and in the presence of scan compression.
Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM (2000)

The ataxia telangiectasia mutated (ATM) gene encodes a serine/threonine protein kinase that plays a critical role in genomic surveillance and development. Here, we use a peptide library approach to define the in vitro substrate specificity of ATM kinase activity. The peptide library analysis identified an optimal sequence with a central core motif of LSQE that is preferentially phosphorylated by ATM. The contributions of the amino acids surrounding serine in the LSQE motif were assessed by utilizing specific peptide libraries or individual peptide substrates. All amino acids comprising the LSQE sequence were critical for maximum peptide substrate suitability for ATM. The DNA-dependent protein kinase (DNA-PK), a Ser/Thr kinase related to ATM and important in DNA repair, was compared with ATM in terms of peptide substrate selectivity. DNA-PK was found to be unique in its preference of neighboring amino acids to the phosphorylated serine. Peptide library analyses defined a preferred amino acid motif for ATM that permits clear distinctions between ATM and DNA-PK kinase activity. Data base searches using the library-derived ATM sequence identified previously characterized substrates of ATM, as well as novel candidate substrate targets that may function downstream in ATM-directed signaling pathways.
Faithful Fabrication of Biocompatible Multicompartmental Memomicrospheres for Digitally Color‐Tunable Barcoding (2020)

Barcodes have attracted widespread attention, especially for the multiplexed bioassays and anti-counterfeiting used toward medical and biomedical applications. An enabling gas-shearing approach is presented for generating 10-faced microspherical barcodes with precise control over the properties of each compartment. As such, the color of each compartment could be programmatically adjusted in the 10-faced memomicrospheres by using pregel solutions containing different combinations of fluorescent nanoparticles. During the process, three primary colors (red, green, and blue) are adopted to obtain up to seven merged fluorescent colors for constituting a large amount of coding as well as a magnetic compartment, capable of effective and robust high-throughput information-storage. More importantly, by using the biocompatible sodium alginate to construct the multicolor microspherical barcodes, the proposed technology is likely to advance the fields of food and pharmaceutics anti-counterfeiting. These remarkable properties point to the potential value of gas-shearing in engineering microspherical barcodes for biomedical applications in the future.
Crystallization and Dynamics of Water Confined in Model Mesoporous Silica Particles: Two Ice Nuclei and Two Fractions of Water (2019)

The crystallization and dynamics of water confined in model mesoporous silica particles (pore diameters ranging from 2.1 to 5 nm; pore length ≈ 1 μm) are studied in homogeneous aqueous suspensions by dielectric spectroscopy, differential scanning calorimetry, and nuclear magnetic resonance (NMR) techniques. We establish the phase diagram ( T vs 1/ d) of confined water covering a broad range of pore diameters. A linear dependence of the heterogeneous and the homogeneous nucleation temperatures on the inverse pore diameter is shown. The two lines converge at a pore diameter of ∼2.6 nm, below which formation of stable crystals is suppressed. By combining dielectric spectroscopy and different NMR techniques, we determine the dynamics of water within mesoporous silica over broad temperature and frequency ranges. Both techniques identify two dynamically distinguishable fractions of confined water coexisting within the pores. We attribute the two fractions to an interfacial water layer at the pore walls and confined water in the pore interior. Two alternative scenarios are proposed to rationalize the coexistence of two dynamically distinguishable water fractions. In the first scenario, two liquid fractions of water coexist under extreme confinement conditions for a range of temperatures; we discuss similarities with the two ultraviscous liquids (high-density liquid and low-density liquid) put forward for supercooled bulk water. In the second scenario, a liquid and a solid phase coexist; we conjecture that highly distorted and unstable crystal nuclei exist under extreme confinement that exhibit reorientation dynamics with time scales intermediate to the surrounding confined liquid and to bulk ice.
Performance Improvements in Conjugated Polymer Devices by Removal of Water‐Induced Traps (2018)

The exploration of a wide range of molecular structures has led to the development of high-performance conjugated polymer semiconductors for flexible electronic applications including displays, sensors, and logic circuits. Nevertheless, many conjugated polymer field-effect transistors (OFETs) exhibit nonideal device characteristics and device instabilities rendering them unfit for industrial applications. These often do not originate in the material's intrinsic molecular structure, but rather in external trap states caused by chemical impurities or environmental species such as water. Here, a highly efficient mechanism is demonstrated for the removal of water-induced traps that are omnipresent in conjugated polymer devices even when processed in inert environments; the underlying mechanism is shown, by which small-molecular additives with water-binding nitrile groups or alternatively water-solvent azeotropes are capable of removing water-induced traps leading to a significant improvement in OFET performance. It is also shown how certain polymer structures containing strong hydrogen accepting groups will suffer from poor performances due to their high susceptibility to interact with water molecules; this allows the design guidelines for a next generation of stable, high-performing conjugated polymers to be set forth.
Intact function of TIL and PBL T cells from early stage NSCLC (2000)

Woo, Edward MD; Goletz, Theresa PhD; Chu, Christina MD; Danet, Guenahel PhD; Doyle, Alden MD; June, Carl MD; Kaiser, Larry MD; Liebowitz, David MD, PhD Author Information
3D Cardiac Cine Imaging in a single Breathhold using Elliptically reordered 3D TrueFISP (2001)

The TrueFISP sequence as proposed by Oppelt et. al. in 1986 (1) offers a high contrast between myocardium and intraventricular cavity, which is desirable for accurate assessment of ventricular function. A significant drawback of TrueFISP is its sensitivity to offresonance
A Dual-Band Modified Franklin mm-Wave Antenna for 5G Wireless Applications (2021)

Franklin array antennas are considered as one of the most competitive candidates for millimeter-wave (mmW) 5G applications due to their compact size, simple geometry and high gain. This paper describes a microstrip Franklin antenna array for fifth generation (5G) wireless applications. The proposed modified Franklin array is based on a collinear array structure with the objective of achieving broad bandwidth, high directivity, and dual-band operation at 22.7 and 34.9 GHz. The designed antenna consists of a 3 × 3 array patch element as the radiating part and a 3 × 3 slotted ground plane operating at a multiband resonance in the mmW range. The dimensions of the patch antennas are designed based on λ/2 of the second resonant frequency. The designed antenna shows dual band operation with a total impedance bandwidth ranging from 21.5 to 24.3 GHz (fractional bandwidth of 12.2%) at the first band and from 33.9 to 36 GHz (fractional bandwidth of 6%) at the second band in simulation. In measurement, the impedance bandwidth ranges from 21.5 to 24.5 GHz (fractional bandwidth of 13%) at the first band and from 34.3 to 36.2 GHz (fractional bandwidth of 5.3%) at the second band, respectively. The performance of the antenna is analyzed by parametric analysis by modifying various parameters of the antenna. All the necessary simulations are carried out using HFSS v.14.0.
Synthesis of (±)-(E,E)-2,7-Dimethylocta-2,4-dienedioic Acid (1999)

(±-(2E,4E)-2,7-Dimethylocta-2,4-dienedioic acid (1) was synthesized efficiently from furan, employing a rhodium-carbenoid-induced furan-ring-unravelling reaction followed by an unusual NaBH4/CeCl3⋅7 H2O reduction, Wittig-Horner olefination, and diester hydrolysis.
In Vivo Investigations of Selected Diamidine Compounds againstTrypanosoma evansiUsing a Mouse Model (2009)

Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continuous emergence of drug resistance, this tactic is failing, and the pressing need for new chemotherapeutic agents is becoming critical. With the introduction of novel aromatic diamidines, a new category of antitrypanosomal drugs was discovered. Nevertheless, their efficacy within a T. evansi-infected mouse model was not known. In total, 30 compounds previously selected based on their in vitro activity were tested in a T. evansi mouse model of infection. Six of the compounds were capable of curing T. evansi-infected mice at drug doses as low as 0.5 and 0.25 mg/kg of body weight administered for 4 consecutive days, and they were more effective than the standard drugs suramin, diminazene, and quinapyramine. After all selection criteria were applied, three diamidine compounds (DB 75, DB 867, and DB 1192) qualified as lead compounds and were considered to have the potential to act as preclinical candidates against T. evansi infection.
Inverted tandem organic solar cells with a MoO3/Ag/Al/Ca intermediate layer (2010)

An inverted tandem organic solar cell, consisting of two bulk heterojunction subcells with identical poly(3-hexylthiophene) and 1-(3-methoxycarbonyl)-propyl-1-phenyl-(6,6)C61 active layer, and an intermediate layer made of ultrathin multiple metal layers of Ca/Al/Ag and metal oxide MoO3, is reported. This intermediate layer is of advantage in high transparency and low series resistance. Moreover, it serves as the charge recombination center effectively, and renders an exact summation of the open-circuit voltages (1.18 V) of the two subcells and a high fill factor (61.8%). The maximum power conversion efficiency obtained is 2.78% under simulated 100 mW/cm2 [air mass (AM) 1.5G] solar irradiation, comparable to those of the two subcells.
Spike propagation path planning on IBM TrueNorth neurosynaptic system (2017)

The authors report on the implementation of a path planning algorithm on the TrueNorth neurosynaptic system. Their implementation exploits processing in the temporal domain within the architectural constraints of the TrueNorth chip to deduce the optimal path. The optimal path is computed on the TrueNorth chip for grid maps with dimensions as large as 173 × 168 nodes consuming ∼70 mW at an operating voltage of 0.8 V.
A Dose-Escalation Study of SAR3419, an Anti-CD19 Antibody Maytansinoid Conjugate, Administered by Intravenous Infusion Once Weekly in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma (2013)

While administered weekly, SAR3419 is well tolerated and active. The qw/q2w schedule that shows an improved safety profile and preserves antilymphoma activity is selected for clinical phase II studies.
Research on a Novel Ka-Band Low Insertion Loss Transmission Line Based on H-Guide (2023)

H-guide and nonradiative dielectric (NRD) waveguide have more favorable prospects in the millimeter wave and even terahertz bands comparing to other waveguides, such as surface plasmon polaritons transmission lines and Goubau line. Basically, the H-guide described in this letter can avoid many of the disadvantages of the other more-conventional guides, such as high losses, low <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula> -factors, poor field confinement and leakage, low power rating, small dimensions leading to severe tolerance problems, and expensive fabrication. In this letter, we analyze the characteristics of H-guide and design an adapter from microstrip line to H-guide. The experimental results are in good agreement with the simulation ones. The measured insertion loss of H-guide with back-to-back transitions ranges from 1.8 to 3.1 dB during 33–37 GHz, where the length of the H-guide reaches 200 mm.