gebhart/patrepeval huggingface dataset:
Facet stability of GaN during tri-halide vapor phase epitaxy: anab initio-based approach (2021)

An<italic>ab initio</italic>-based approach is used to study the facet stability of GaN during THVPE. The surface phase diagrams as functions of temperature and pressure are determined. Wulff construction is used to predict the crystal shape.
COAGULATION MARKERS PREDICTING CARDIAC TRANSPLANT REJECTION1 (2001)

In heart transplant recipients, p-selectin levels and PF 1.2 levels are highly predictive of organ rejection. The elevation of PF 1.2 suggests that there is systemic generation of thrombin generation. These markers may be useful for noninvasively monitoring patients for organ rejection or for after response to treatment.
Preparation of agar wells for antibiotic assay (1968)

A variety of devices such as stainless-steel or ceramic cylinders, single or multiple in design, and paper discs of several sizes are commonly used for antibiotic assays performed by the agar diffusion method. Holes cut in agar (agar wells) are wells with melted agar is often necessary to obtain uniform inhibition zones (2). This note describes a method for the preparation of agar-well plates which obviates the disadvantages. In our laboratory, agar-well assays
Contactless Rotor Excitation for Traction Motors (2018)

This paper proposes a new rotary transformer topology enabling significant reduction of leakage inductances, improvement of coupling factor and significant improvement of power transfer capability compared to traditional topologies thanks to its interleaved windings and resonant compensation circuits. The proposed rotary transformer features a non-ferrite rotating part made of lightweight strong non-conductive and non-magnetic composite material and a large airgap, allowing safe operation at high rotational speeds. Hence, this novel rotary transformer can enable the adoption of wound rotor synchronous machines for electric or hybrid vehicle traction. The performance of the proposed new topology was evaluated and compared to the conventional one. Significant performance improvement was confirmed.
A recombinant ‘ACE2 Triple Decoy’ that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants (2021)

ABSTRACT The highly-transmissible SARS-CoV-2 variants now replacing the first wave strain pose an increased threat to human health by their ability, in some instances, to escape existing humoral protection conferred by previous infection, neutralizing antibodies, and possibly vaccination. Thus, other therapeutic options are necessary. One such therapeutic option that leverages SARS-CoV-2 initiation of infection by binding of its spike receptor binding domain (S RBD) to surface-expressed host cell angiotensin-converting enzyme 2 (ACE2) is an ACE2 ‘decoy’ that would trap the virus by competitive binding and thus inhibit propagation of infection. Here, we used Molecular Dynamic (MD) simulations to predict ACE2 mutations that might increase its affinity for S RBD and screened these candidates for binding affinity in vitro . A double mutant ACE2(T27Y/H34A)-IgG 1 F C fusion protein was found to have very high affinity for S RBD and to show greater neutralization of SARS-CoV-2 in a live virus assay as compared to wild type ACE2. We further modified the double mutant ACE2 decoy by addition of an H374N mutation to inhibit ACE2 enzymatic activity while maintaining high S RBD affinity. We then confirmed the potential efficacy of our ACE2(T27Y/H34A/H374N)-IgG 1 F C Triple Decoy against S RBD expressing variant-associated E484K, K417N, N501Y, and L452R mutations and found that our ACE2 Triple Decoy not only maintains its high affinity for S RBD expressing these mutations, but shows enhanced affinity for S RBD expressing the N501Y or L452R mutations and the highest affinity for S RBD expressing both the E484K and N501Y mutations. The ACE2 Triple Decoy also demonstrates the ability to compete with wild type ACE2 in the cPass™ surrogate virus neutralization in the presence of S RBD with these mutations. Additional MD simulation of ACE2 WT and decoy interactions with S RBD WT or B.1.351 variant sequence S RBD provides insight into the enhanced affinity of the ACE2 decoy for S RBD and reveals its potential as a tool to predict affinity and inform therapeutic design. The ACE2 Triple Decoy is now undergoing continued assessment, including expression by a human adenovirus serotype 5 (hAd5) construct to facilitate delivery in vivo . Summary sentence An ACE2(N27Y/H34A/H374N)-IgG 1 F C fusion protein decoy sustains high affinity to all SARS-CoV-2 spike receptor binding domain (RBD) protein variants tested, shows enhanced affinity for the N501Y and L452R variants, and the highest affinity for combined N501Y and E484K variants.
Addressing Neurological Disorders With Neuromodulation (2011)

Neurological disorders are becoming increasingly common in developed countries as a result of the aging population. In spite of medications, these disorders can result in progressive loss of function as well as chronic physical, cognitive, and emotional disability that ultimately places enormous emotional and economic on the patient, caretakers, and the society in general. Neuromodulation is emerging as a therapeutic option in these patients. Neuromodulation is a field, which involves implantable devices that allow for the reversible adjustable application of electrical, chemical, or biological agents to the central or peripheral nervous system with the objective of altering its functioning with the objective of achieving a therapeutic or clinically beneficial effect. It is a rapidly evolving field that brings together many different specialties in the fields of medicine, materials science, computer science and technology, biomedical, and neural engineering as well as the surgical or interventional specialties. It has multiple current and emerging indications, and an enormous potential for growth. The main challenges before it are in the need for effective collaboration between engineers, basic scientists, and clinicians to develop innovations that address specific problems resulting in new devices and clinical applications.
Notice of Removal: Ultrasonic method for monitoring muscle water content (2017)

Removed.
real-time video on the Web using dynamic rate shaping (2002)

We propose an architecture which can support video services in networks which have no quality of services (QoS) guarantees. We demonstrate that there is a need for such services today and also in the future, when QoS will be built into most networks. We then describe our current Internet-based system, which combines both image processing and networking techniques in order to provide good quality video without harming the performance of the Internet. These techniques are shown to be superior to previous work for the environment of video services operating in the Internet. We also present experimental results gathered in both a controlled environment and in external wide area connections across the Internet.
Oxidation of Organic Sulfides by Br2 and H2O2. Electrophilic and Free-Radical Processes (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTOxidation of Organic Sulfides by Br2 and H2O2. Electrophilic and Free-Radical ProcessesAnna Bravo, Barbara Dordi, Francesca Fontana, and Francesco MinisciView Author Information Dipartimento di Chimica del Politecnico, via Mancinelli 7, 20131 Milano MI, Italy, and Università di Bergamo, Dipartimento di Ingegneria, viale Marconi 5, 24044 Dalmine BG, Italy [email protected]Cite this: J. Org. Chem. 2001, 66, 9, 3232–3234Publication Date (Web):April 11, 2001Publication History Received7 December 2000Published online11 April 2001Published inissue 1 May 2001https://doi.org/10.1021/jo0017178Copyright © 2001 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1459Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (37 KB) Get e-AlertsSUBJECTS:Alcohols,Oxidation,Oxides,Pharmaceuticals,Sulfides Get e-Alerts
Development of Nanotechnology Pipe Treatment to Improve Acoustic Cement Evaluation (2017)

Abstract The bond between casing and cement placed in the annulus is an important aspect to wellbore construction. Bond is inferred after the cement has cured using acoustic methods well-known in the industry. This evaluation is dependent on the acoustic coupling between the cement and the pipe. If acoustic coupling exists, proper evaluation allows for a subjective assessment of the cement sheath behind casing. However, if the acoustic coupling is weak, non-existent, or has been damaged by operations such as pressure testing or stimulation treatments, the cement may be present but cannot be properly evaluated, leading to ambiguous conclusions and ultimately unnecessary remedial cementing. Enhancements to the casing/cement bond is achieved by use of surfactants, expansion agents, and other chemicals added to the cement slurry and/or spacer. Modification to completion practices is sometimes practiced to prevent bond disturbance. Modifications to the mechanical properties of the cement sheath are also done in an attempt to prevent or limit the permanent deformation to the cement sheath that occurs during these load events. All have varying degrees of success and cost. Attempts to modify the surface of the steel pipe have been practiced for several decades with varying results. The simplest and most effective has been to grit-blast the casing to remove mill varnish, as varnish highly hydrophobic and not conducive to cement bonding. Grit blasting also leaves the surface slightly roughened, which has been proven to improve both shear bond and acoustic transmittance. Coatings have been attempted in the past, usually based on altering the surface roughness by adhering grit using an adhesive. None of the afore-mentioned methods practiced to date have addressed two fundamentals: (1) carbon steel is naturally hydrophobic, and (2) cement and steel do not form a chemical bond. The purpose of this project was to address these short-comings by developing a method to modify the external surface of oil well pipe making it super-hydrophilic, and at the same time attempt to create a chemical bond to cement. Through a collaborative working relationship between this major operator and a small innovative technology company, a successful nano-technology treatment process has been developed and field tested in both unconventional and Deepwater environments. This paper will chronicle the project from concept development to lab proof-of-concept, several field trials, and provide a review of the lessons learned along the way. Comparative cement evaluation logs will be reviewed that show a significant improvement in some cases between the treated pipe and pipe that is either unmodified or grit-blasted.
Use of Telepresence Robots in Glaucoma Patient Education (2020)

Education sessions with a human and TR improved patients' glaucoma KS. TRs may serve as an alternative to in-person education sessions and allow educators to safely and effectively educate patients remotely to adhere to COVID-19 social distancing guidelines.
Intraventricular cryptococcal granuloma (1988)

Infection by Cryptococcus neoformans, a budding nonmycelial yeast, involves the central nervous system in 70% of patients at the time of diagnosis. Meningitis and meningoencephalitis are common manifestations of infection; solid granulomas occur but are unusual, and intraventricular granulomas are distinctly rare. Two cases of intraventricular cryptococcal granuloma are reported. The diagnosis and treatment of mass lesions due to cryptococcal infection are discussed, with special reference to intraventricular granulomas.
Assessment of landfill processes in simulation reactors with municipal solid waste containing organic pollutants (2001)

Assessment of landfill processes in simulation reactors with municipal solid waste containing organic pollutants
Segmentation of extracellular microelectrode recordings with equal power (2004)

We describe a segmentation algorithm for extracellular microelectrode recordings identifying segments with equal power. The observed temporal correlation of the microelectrode data was accounted for by estimating the variance of the autocovariance of the segments. The iterative method of comparing segments and determining abrupt changes in the power was validated on synthetic signals and microelectrode recording data acquired at different neuronal structures along the stereotactic trajectory in patients with Parkinson disease.
ChemInform Abstract: Solid‐Phase Synthesis of Cyclic Peptides (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy (1996)

Factor VIIa (fVIIa) is composed of four discrete domains, a gamma-carboxyglutamic acid (Gla)-containing domain, two epidermal growth factor (EGF)-like domains, and a serine protease domain, all of which appear to be involved, to different extents, in an optimal interaction with tissue factor (TF). All except the second EGF-like domain contain at least one Ca2+ binding site and many properties of fVIIa, e.g., TF and phospholipid binding and amidolytic activity, are Ca(2+)-dependent. A CD study was performed to characterize and locate the conformational changes in fVIIa induced by Ca2+ and TF binding. In addition to intact fVIIa, derivatives lacking the Gla domain or the protease domain were used. Assignment of the Ca(2+)-induced changes in the far-UV region of the fVIIa spectrum to the Gla domain could be made by comparing the CD spectra obtained with these fVIIa derivatives. The changes primarily appeared to reflect a Ca(2+)-induced ordering of alpha-helices existing in the apo state of fVIIa. This was corroborated by models of the apo and Ca2+ forms of fVIIa, obtained as difference spectra between fVIIa derivatives, were very similar to those of isolated Gla peptides from other vitamin K-dependent plasma proteins. The near-UV CD spectrum of fVIIa was dominated by aromatic residues residing in the protease domain and specific bands affected by Ca2+ were indicative of tertiary structural alterations. The formation of a fVIIa:TF complex led to secondary structural changes that appeared to be restricted to the catalytic domain, possibly shedding light on the mechanism by which TF induces an enhancement of fVIIa catalytic activity.
Learning to Speak Fluently in a Foreign Language: Multilingual Speech Synthesis and Cross-Language Voice Cloning (2019)

We present a multispeaker, multilingual text-to-speech (TTS) synthesis model based on Tacotron that is able to produce high quality speech in multiple languages.Moreover, the model is able to transfer voices across languages, e.g.synthesize fluent Spanish speech using an English speaker's voice, without training on any bilingual or parallel examples.Such transfer works across distantly related languages, e.g.English and Mandarin.Critical to achieving this result are: 1. using a phonemic input representation to encourage sharing of model capacity across languages, and 2. incorporating an adversarial loss term to encourage the model to disentangle its representation of speaker identity (which is perfectly correlated with language in the training data) from the speech content.Further scaling up the model by training on multiple speakers of each language, and incorporating an autoencoding input to help stabilize attention during training, results in a model which can be used to consistently synthesize intelligible speech for training speakers in all languages seen during training, and in native or foreign accents.
Metalloproteinase Inhibitors Inhibit the Release of Soluble CD27 by Waldenstrom's Macroglobulinemia Cells. (2009)

Abstract Abstract 3942 Poster Board III-878 Waldenström's macroglobulinemia (WM) is characterized by bone marrow infiltration with lymphoplasmacytic cells (LPCs), and increased presence of mast cells. CD27 is a marker of memory B-cells, and is heterogeneously expressed on the cell surface of WM cells. In recent studies, we showed that the soluble CD27 (sCD27) is produced by WM LPC and is a faithful marker of disease burden in WM patients. Importantly, sCD27 triggers via CD70 the expression of CD40L on neighboring Mast Cells, which in turn supports the growth and survival of WM LPC. sCD27 therefore represents a promising target for the treatment of WM. The mechanism for sCD27 release in WM remains to be elucidated, but is likely cleaved from cell surface CD27. We therefore examined the effects of various matrix metalloproteinase (MMP) inhibitors on the production of sCD27. sCD27 levels were measured by ELISA from supernatants of cultured BCWM.1 and BL2126 B-cells transfected with a vector expressing either FLAG-tagged CD27 (pCD27-FLAG) or a control vector. PMA treatment of pCD27-FLAG transfected BCWM.1 WM and BL2126 cells led to sustained sCD27 release in cultured supernatants; in contrast, PMA treatment of control vector transfected cells showed minimal sCD27 release. Importantly, treatment of pCD27-FLAG transfected BCWM.1 WM and BL2126 cells with MMP 8 and MMP 3 inhibitors (Calbiochem) led to four-fold and two-fold decrease in sCD27 levels, respectively (Figure 1). In contrast, no significant change in sCD27 release was observed following treatment with MMP 2/9 or non-specific MMP inhibitors. These studies demonstrate that matrix metalloproteinases play an important role in sCD27 release, and provide the framework for efforts examining MMP 8 and 3 specific inhibitors in the treatment of WM. Disclosures: No relevant conflicts of interest to declare.
Novel chromophores from alternated pyridine–ethylenedioxythiophene unit oligomers: dramatic enhancement of photoluminescence properties in elongated derivatives (2008)

Novel chromophores based on the alternation of electron-poor (pyridyl) and electron-rich (ethylenedioxythienyl) heterocycles were synthesized for the first time and shown to exhibit attractive optical properties in relation with their specific electronic and geometrical (coiled structure) features.
The maximal size of a minimal generating set (2023)

A generating set for a finite group $G$ is said to be minimal if no proper subset generates $G$, and $m(G)$ denotes the maximal size of a minimal generating set for $G$. We prove a conjecture of Lucchini, Moscatiello and Spiga by showing that there exist $a,b &gt; 0$ such that any finite group $G$ satisfies $m(G) \leq a \cdot δ(G)^b$, for $δ(G) = \sum_{\text{$p$ prime}} m(G_p)$ where $G_p$ is a Sylow $p$-subgroup of $G$. To do this, we first bound $m(G)$ for all almost simple groups of Lie type (until now, no nontrivial bounds were known except for groups of rank $1$ or $2$). In particular, we prove that there exist $a,b &gt; 0$ such that any finite simple group $G$ of Lie type of rank $r$ over the field $\mathbb{F}_{p^f}$ satisfies $r + ω(f) \leq m(G) \leq a(r + ω(f))^b$, where $ω(f)$ denotes the number of distinct prime divisors of $f$. In the process, we confirm a conjecture of Gill and Liebeck that there exist $a,b &gt; 0$ such that a minimal base for a faithful primitive action of an almost simple group of Lie type of rank $r$ over $\mathbb{F}_{p^f}$ has size at most $ar^b + ω(f)$.
Computations of SAR distributions for two anatomically based models of the human head using CAD files of commercial telephones and the parallelized FDTD code (1998)

A method for importing data from computer-aided design (CAD) files for a mobile telephone into finite-difference time-domain (FDTD) simulation software is described. Although the FDTD method is well suited for the bio-electromagnetic simulations and has become the method of choice for most researchers in this area, there may be some limitations to its use. Limitations include, the description of the source (e,g., the mobile telephone) and the fact that the FDTD method requires large amounts of memory and computational power. The size of the computational space is dependent upon both the physical size of the model and its resolution. Higher frequencies of operation require higher resolutions. This could place the solution of some problems outside the capabilities of the technique. Often the telephone has to be represented by a plastic covered metal box, which approximates the shape of the actual device. The paper addresses these problems. Wires and circuit boards inside the telephone can act as resonant elements if they are not shielded. This potential problem is also considered. The large problem size associated with high-resolution FDTD simulations is accommodated by the use of a parallel implementation of the FDTD method (run on an IBM SP-2). The techniques developed are used for two anatomically based head models that have been developed from magnetic resonance imaging (MRI) of two human subjects. The usefulness of the techniques developed and comparisons of the specific absorption rates (SARs) in the two models are discussed.