gebhart/patrepeval huggingface dataset:
Effect of Processing Route on the Morphology of Thermoplastic Polyurethane (TPU) Nanocomposites Incorporating Organofluoromica (2013)

In the production of polymer nanocomposites, the processing method determines the dispersion of the nanofiller and hence, the final nanocomposite properties. In this work, the potential of high energy milling of the organofluoromica to improve the platelet dispersion and exfoliation in both solvent cast and melt processed thermoplastic polyurethane (TPU)/organofluoromica nanocomposites was investigated. The potential of high energy milling of the organofluoromica to improve the platelet dispersion and exfoliation in both solvent cast and melt processed thermoplastic polyurethane (TPU)/organofluoromica nanocomposites was investigated. The applied high energy milling process has successfully reduced this nanofiller platelet length from 640 nm to 400 nm and 250 nm after 1 hour and 2 hours respectively. These lower aspect ratio milled nanofillers resulted in improved quality of dispersion and delamination when incorporated into the TPU and hence interacted more preferentially with the TPU matrix.
C for T substitution at codon 108: the first identified silent mutation in the transthyretin gene (1997)

Transthyretin (TTR) is a 55kDa tetrameric protein synthesized by the liver and the choroid plexus that binds thyroxine and retinol-binding protein. More than fifty mutations have been identified in the TTR gene, the majority of them associated with hereditary amyloidosis1. This study reveals the first silent mutation on the TTR gene : Ala108.
Complete Sequence of the Closed Circular Extrachromosomal Element of Naegleria jadini Willaert and Ray (Strain ITMAP400) (2023)

Amoebae of the <i>Naegleria</i> genus carry all ribosome-encoding DNA on closed circular extrachromosomal elements (CERE). We report the sequence of the CERE of Naegleria jadini (strain Willaert and Ray).
Fig S3 from A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes (2023)

&lt;p&gt;In vivo processing&lt;/p&gt;
Real-World Haptics: Reproduction of Human Motion (2012)

In recent years, communication technologies have grown rapidly and from the communication point of view, real-world haptics is the key technology for future haptic technology. Consequently, this article focuses on the storage and reproduction methods for haptic information in the real world. The bilateral connection of haptic systems with force feedback ability makes telecommunication among remote human operators possible. This article shows a motion-copying system (MCS) as a spatiotemporal coupler of real-world haptic information. As with sound and visual information, an MCS is capable of storing and reproducing raw force and position information of human operator. Once human motion is stored using MCS, it is possible to reproduce it at any time and place. This will be useful for the digital preservation of motions by skilled experts as a haptic database.
Hydrological signatures of earthquake strain (1993)

The character of the hydrological changes that follow major earthquakes has been investigated and found to be dependent on the style of faulting. The most significant response is found to accompany major normal fault earthquakes. Increases in spring and river discharges peak a few days after the earthquake, and typically, excess flow is sustained for a period of 6–12 months. In contrast, hydrological changes accompanying pure reverse fault earthquakes are either undetected or indicate lowering of well levels and spring flows. Strike‐slip and oblique‐slip fault movements are associated with a mixture of responses but appear to release no more than 10% of the water volume of the same sized normal fault event. For two major normal fault earthquakes in the western United States (those of Hebgen Lake on August 17, 1959, and Borah Peak on October 28, 1983), there is sufficient river flow information to allow the magnitude and extent of the postseismic discharge to be quantified. The discharge has been converted to a rainfall equivalent, which is found to exceed 100 mm close to the fault and to remain above 10 mm at distances greater than 50 km. The total volume of water released in these earthquakes was around 0.3 km 3 (Borah Peak) and 0.5 km3 (Hebgen Lake) Qualitative information on other major normal fault earthquakes, in both the western United States and Italy, indicates that the size, duration, and range of their hydrological signatures have been similar. The magnitude and distribution of the water discharge for these events are compared with deformation models calibrated using seismic and geodetic information. The quantity of water released over a time period of 6–12 months suggests that crustal volume strain to a depth of at least 5 km is involved. The rise and decay times of the discharge are shown to be critically dependent on crack widths, and it is concluded that the dominant cracks have a high aspect ratio and cannot be much wider than 0.03 mm. Using the estimated depth to which water is mobilized, the modeled crack size, and the measured volumes of water expelled, it is concluded that even at distances of 50 km from the earthquake epicenters, cracks must be separated by no more than 10 or 20 m. In regions of highest discharge nearer the earthquake epicenters, separations of 1 or 2 m are required. These results suggest that water‐filled cracks are ubiquitous throughout the brittle continental crust and that these cracks open and close throughout the earthquake cycle. The existence of tectonically induced fluid flows on the scale that we demonstrate has major implications for our understanding of the mechanical and chemical behavior of crustal rocks.
Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol (2019)

To report successful medical management of Pythium insidiosum keratitis using an antibiotic combination of minocycline, linezolid, and chloramphenicol. A 20-year-old Japanese man was referred for visual disturbance, hyperemia, and discharge from his right eye. Slit-lamp examination revealed a paracentral corneal hyphate ulcer. His visual acuity was 20/28. Smear examination of corneal scrapings revealed a filamentous fungus. Pimaricin ointment four times a day and voriconazole eye drops hourly were initially prescribed. Although intravenous liposomal amphotericin B 100 mg was added, the corneal infiltrates and ulcer worsened. The possibility of P. insidiosum keratitis was considered, and in vitro antifungal susceptibility testing were performed based on the disc diffusion method. The inhibition zones around each antibiotic disc revealed that the pathogen was susceptible to minocycline, linezolid, and chloramphenicol. Therefore, minocycline ointment four times a day, chloramphenicol eye drops hourly, and linezolid 1200 mg orally per day were also administered. Eventually, sequencing of ribosomal DNA confirmed the pathogen to be P. insidiosum. The triple regimen dramatically improved the patient's keratitis. Therapeutic penetrating keratoplasty for corneal perforation was successfully performed, and his visual acuity recovered from 20/2000 to 20/25. We have encountered a case of P. insidiosum keratitis that responded to a combination of minocycline, linezolid, and chloramphenicol. This triple combination should be considered in patients with P. insidiosum keratitis.
Optimal Design Considerations for a Modified LLC converter with wide input voltage range capability suitable for PV applications (2011)

The paper proposed a modified LLC converter with two transformers in series, which has four operation configurations, covering the range of four times the minimum input voltage. To optimize the proposed LLC converter in attempt to achieve good efficiency, a numerical method is developed based on the LLC converter's steady state equations. Optimal criterion and optimization procedure are given to guide optimal design for LLC converters and an optimal design example is given as well. A 250W 210V output prototype with input voltage ranging from 25V to 100V is built to verify the proposed converter and the developed numerical model. Experimental results show the proposed converter can achieve the efficiency up to 98%, while maintaining a very wide input voltage range.
Electron capture negative ion chemical ionization mass spectrometry (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron capture negative ion chemical ionization mass spectrometryDonald F. Hunt and Frank W. CrowCite this: Anal. Chem. 1978, 50, 13, 1781–1784Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/ac50035a017https://doi.org/10.1021/ac50035a017research-articleACS PublicationsRequest reuse permissionsArticle Views1084Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accuracy of acetabular component alignment with surgical guidance systems during hip arthroplasty (2023)

Therapeutic Level II.
TACAWS/FMTI Launcher Simulation. (1997)

Abstract : This report documents the development of a dynamic model of The Army Combined Arms Weapon System (TACAWS) or Future Missile Technology Integration (FMTI) launcher. The model was developed to characterize the launch velocity and tipoff rate of the TACAWS missile and was verified by a slug missile test.
Dynamic Systemic Vascular Resistance in a Sheep Supported with a Nimbus AxiPump (1994)

Changes in systemic vascular resistance (SVR) in response to diminished pulse perfusion were analyzed over a dynamic range of flow conditions. An axial flow LVAD (Nimbus AxiPump, Rancho Cordova, CA) was implanted in a sheep for 28 days, during which time SVR was determined over several conditions of posture and excitability. Total arterial resistance (TR) was calculated dynamically as an index of SVR by analysis of pump flow in diastole, and systemic pressure estimated from the characteristic pressure–flow–speed relation of the AxiPump. TR was evaluated over a range of flow rates, including maximum flow—for which the pressures and flows were essentially nonpulsatile. Throughout the course of support, and independent of pulsatility, TR dropped when the sheep stood and was significantly lower than that in the sitting position (P < 0.01). Response to excitement followed the same trend: TR was significantly higher during agitation than during normal temper (P < 0.01). In spite of changes in pulse pressure and flow rate, SVR changes occurred according to expected physiologic responses for pulsatile perfusion. Because pump flow and pressure are sensitive to afterload, the results of these studies suggest that pump speed control must compensate for changes in SVR to maintain acceptable perfusion.
The epidermal growth factor-like domain from tissue plasminogen activator. Cloning in E. coli, purification and ESR studies of its interaction with human blood platelets. (1994)

To examine whether the epidermal growth factor (EGF)-like domain Pro47-Asp87 is involved in the interaction of tissue plasminogen activator (t-PA) with platelets, we have expressed this domain in E. coli. The peptide fragment was produced from a plasmid expression vector as a fusion protein with beta-galactosidase Met1-Val444 at high yield in eight clones of E. coli. The fusion protein was purified and subjected to mild acid hydrolysis with formic acid, then the peptide Pro47-Asp87, identified by immunoblotting using specific antibodies to t-PA, was isolated by HPLC. After incubation with blood platelets spin labelled with 16-doxylstearic acid or 5-doxylstearic acid, the Pro47-Asp87 peptide fragment reduced fluidity of the membrane lipid bilayer to the same extent as did intact t-PA as indicated by ESR measurements. Our data suggest that the EGF-like domain of t-PA can directly interact with blood platelets and thus it seems to contain those sites of the t-PA molecule that bind the platelet membrane components.
Effect of the ERα agonist GTx-758 on bone turnover markers in men with advanced prostate cancer. (2013)

222 Background: Men with advanced prostate cancer are being treated with androgen deprivation therapy (ADT) for longer periods of time. The use of ADT can be limited by estrogen deficiency side effects, including a loss of bone and a higher incidence of fractures. GTx-758 is an ERα agonist that lowers serum free testosterone greater than an LHRH agonist. Herein we compare the effects of GTx-758 and leuprolide on markers of bone turnover, C-terminal telopeptides and bone specific alkaline phosphatase, in men with advanced prostate cancer treated with ADT. Methods: In a Phase II study (G200705), men with advanced prostate cancer (n=159) received 1000 mg or 2000 mg of GTx-758 daily or leuprolide. Serum samples were collected and analyzed by a reference laboratory. C-terminal telopeptides (pg/ml) and bone specific alkaline phosphatase (U/L) were measured as indicators of bone turnover. All p values describe the comparison of the GTx-758 treatment groups to the leuprolide treated men at day 120. Results: Men receiving the 1000 mg and 2000 mg doses of GTx-758 had lower C-terminal telopeptide levels with a mean percentage change of -56.9 ± 12.5 and -54.8 ± 23.1, respectively, as compared with an increase of 46.0 ± 48.9 percentage in the men receiving the leuprolide (p&lt;0.001). Similarly, bone specific alkaline phosphatase levels were lower in men treated with GTx-758, with mean percentage changes of-28.5 ± 11.7 and -19.8 ± 14.7, respectively, compared with an increase of 8.1 ± 24.3 percent in the leuprolide treated group (p&lt;0.001). As a result of an increased risk of venous thromboembolic events (VTEs) at these higher doses of GTx-758, the trial was stopped prior to its completion and not all of the men on the study reached the 120 day treatment dates (71 evaluable). Conclusions: Patients receiving GTx-758 experienced a significant decrease in markers of bone turnover indicating potential improvement and not a loss of bone on ADT. Since changes in bone mineral density are a major side effect that can negatively affect the quality of life in men on ADT, the improvements in bone turnover observed in men treated with GTx-758 could be significant. A Phase II clinical trial utilizing lower doses of GTx-758 (G200712) is currently being performed. Clinical trial information: NCT01326312.
Encapsulation of Single Small Gold Nanoparticles by Diblock Copolymers (2008)

Hairy micelles are obtained by using amphiphilic diblock copolymers with long hydrophilic blocks which favor single encapsulation of Au nanoparticles (ca. 5 nm, see figure). Antibody molecules can be attached to the hydrogel layers of the encapsulated Au nanoparticles to give nanoparticle/biomolecule conjugates. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2267/2008/z700598_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta (2012)

Inhibition of PI3Kδ is considered to be an attractive mechanism for the treatment of inflammatory diseases and leukocyte malignancies. Using a structure-based design approach, we have identified a series of potent and selective benzimidazole-based inhibitors of PI3Kδ. These inhibitors do not occupy the selectivity pocket between Trp760 and Met752 that is induced by other families of PI3Kδ inhibitors. Instead, the selectivity of the compounds for inhibition of PI3Kδ relative to other PI3K isoforms appears to be due primarily to the strong interactions these inhibitors are able to make with Trp760 in the PI3Kδ binding pocket. The pharmacokinetic properties and the ability of compound 5 to inhibit the function of B-cells in vivo are described.
Efficient Synthesis of Light‐Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression (2018)

Light-activated ("caged") antisense oligonucleotides are powerful molecules for regulating gene expression at submicron spatial resolution through the focal modulation of endogenous cellular processes. Cyclized caged oligos are particularly promising structures because of their inherent stability and similarity to naturally occurring circular DNA and RNA molecules. Here, we introduce an efficient route for cyclizing an antisense oligodeoxynucleotide incorporating a photocleavable linker. Oligo cyclization was achieved for several sequences in nearly quantitative yields through intramolecular copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Caging stability and light activation were characterized by FRET efficiency, denaturing gel assay, and melting temperature measurements. Finally, a cyclized caged oligo was designed to target gfap, and it gave a tenfold reduction in glial fibrillary acidic protein upon photoactivation in astrocytes.
The Insulin Receptor: Molecular Biology and Transmembrane Signaling* (1987)

INSULIN is a major regulatory hormone for most, if not all, cells. It is important to understand the molecular mechanisms of insulin action not only because it is a major anabolic hormone, but also because insulin action is impaired in the vast majority of patients with noninsulin dependent diabetes mellitus (NIDDM) (1). How insulin carried out its various cellular actions remains a mystery. While the secrets of other hormones such as steroid hormones, hormones that use cAMP, and hormones that use calcium have fallen to the onslaught of persistent investigators, insulin has not yielded. Over the past several years, however, progress has been made that has enhanced our knowledge of how insulin regulates target cells. This review will attempt to highlight some of these recent advances. In most tissues, insulin is involved in the metabolism of sugars, lipids, amino acids, and ions. In target cells insulin has three major sites of metabolic regulation (2–4) (Fig. 1).
Insulin Resistance and Inflammation as Precursors of Frailty (2007)

Background:Ourresearchgrouphaspreviouslyshown that the geriatric syndrome of frailty is associated with features of the metabolic syndrome (MetS) on crosssectional analysis. Methods: To test whether MetS and its physiologic determinants—insulin resistance as measured by homeostasismodelassessmentscore(IR-HOMA),increasedinflammation and coagulation factor levels, and elevated blood pressure—are associated with incident frailty, we studied asubcohortofparticipantsfromtheCardiovascularHealth Studyobservedfrom1989/1990through1998/1999:3141 community-dwelling adults, aged 69 to 74 years, without frailtyandillnessesthatincreaseinflammationmarkersor mimicfrailty.TheassociationofbaselineMetS,IR-HOMA, levelsofinflammationandcoagulationfactors,andsystolic blood pressure (SBP) with time to onset of frailty was adjusted for demographic and psychosocial factors and incidentevents.Ourmainoutcomemeasurewasincidentfrailty. Results: Metabolic syndrome was not significantly associatedwithincidentfrailty(hazardratio,1.16(95%confidence interval [CI], 0.85-1.57). On the other hand, IR-HOMA and C-reactive protein levels were associated with incident frailty: for every standard deviation increment the hazard ratio for frailty was 1.15 (95% CI, 1.021.31) and 1.16 (95% CI, 1.02-1.32), respectively. The white blood cell count and factor VIIIc levels had a borderline association. Elevated systolic blood pressure had noassociation.Similartrendswerefoundforincidentprefrailty, a condition that precedes frailty. Conclusions: Two physiologic components of MetS—IR-HOMAandinflammation—areassociatedwith incident frailty. Based on these results, IR-HOMA can be considered part of a larger process that leads to generalized decline. Arch Intern Med. 2007;167:635-641
A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A Virus (2011)

The NA of contemporary seasonal H1N1 influenza strains induces a cross-reactive antibody response to pH1N1 that correlates with reduced lethality from pH1N1 challenge, albeit less efficiently than anti-pH1N1 NA antibodies. These findings demonstrate that seasonal NA antibodies contribute to but are not sufficient for cross-reactive immunity to pH1N1.
Search for resonant pair production of Higgs bosons decaying to bottom quark-antiquark pairs in proton-proton collisions at 13 TeV (2018)

A bstract A search for a narrow-width resonance decaying into two Higgs bosons, each decaying into a bottom quark-antiquark pair, is presented. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 35.9 fb −1 at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:math> TeV recorded by the CMS detector at the LHC. No evidence for such a signal is observed. Upper limits are set on the product of the production cross section for the resonance and the branching fraction for the selected decay mode in the resonance mass range from 260 to 1200 GeV.
Multiple-robot drug delivery strategy through coordinated teams of microswimmers (2014)

Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.