gebhart/patrepeval huggingface dataset:
The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19 (2021)

Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, therefore, at a higher risk of having TL-dependent lymphopenia. We measured TL by the novel Telomere Shortest Length Assay (TeSLA), and by Southern blotting (SB) of the terminal restriction fragments in peripheral blood mononuclear cells of 17 COVID-19 and 21 non-COVID-19 patients, aged 87 ± 8 (mean ± SD) and 87 ± 9 years, respectively. TeSLA tallies and measures single telomeres, including short telomeres undetected by SB. Such telomeres are relevant to TL-mediated biological processes, including cell viability and senescence. TeSLA yields 2 key metrics: the proportions of telomeres with different lengths (expressed in %) and their mean (TeSLA mTL), (expressed in kb). Lymphocyte count (109/L) was 0.91 ± 0.42 in COVID-19 patients and 1.50 ± 0.50 in non-COVID-19 patients (p < .001). In COVID-19 patients, but not in non-COVID-19 patients, lymphocyte count was inversely correlated with the proportion of telomeres shorter than 2 kb (p = .005) and positively correlated with TeSLA mTL (p = .03). Lymphocyte count was not significantly correlated with SB mTL in either COVID-19 or non-COVID-19 patients. We propose that compromised TL-dependent T-cell proliferative response, driven by short telomere in the TL distribution, contributes to COVID-19 lymphopenia among old adults. We infer that infection with SARS-CoV-2 uncovers the limits of the TL reserves of older persons. Clinical Trials Registration Number: NCT04325646.
Coherent Dynamics of the Localized Vibrational Modes of Hydrogen inCaF2 (2000)

We report the observation of giant quantum coherence effects in the localized modes of ionized hydrogen in synthetic fluorite. Infrared free induction decay experiments on the substitutional H- center show dramatic modulations at negative delay times due to interference between multiple vibrational levels. Spectrally resolving the degenerate four wave mixing signal allows unambiguous assignments of the participating vibrational states. The dependence of the signal intensity upon the delay path between the exciting free electron laser pulses can be accounted for in terms of the resonant third order polarization with a common dephasing time for the excited states.
Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy (2010)

Pathological upstaging is prevalent and survival remains modest in patients with cT2 tumours treated with RC without NC. Unfortunately, only 40% of patients that had locally advanced and/or regionally metastatic disease received adjuvant treatment. These data further support the value of NC for patients with muscle-invasive bladder cancer, even in those with apparent clinically organ-confined tumours.
Marcio Cappelli, A teologia ficcional de José Saramago. Aproximações entre Romance e Reflexão Teológica (2022)

O título A Teologia Ficcional de José Saramago tem tudo para desencadear o interesse, não a indiferença, por mais este livro sobre a ficção de Saramago. Se conhecer com alguma profundidade a obra de Saramago ou se dela tiver ao menos algumas noções, um crente verá neste título, com surpresa e não pouca perplexidade, um desafio de interpretação e procurará uma resposta convincente para a contradição que parece existir entre as duas partes do título (« teologia ficcional » versus « de José Sara...
Analysis of a High-Speed Solenoid-Actuated Mechanism (1968)

The mechanism which is considered in this paper is a high-speed, solenoid-driven, impact printing mechanism. The purpose of the analysis is to construct a mathematical model of the mechanism from which the dynamics of the mechanism can be studied during a complete printing cycle. The basic approach taken is to construct a lumped parameter model of the mechanical system. Motion equations are written which are solved simultaneously with equations governing the electromagnetic system. Elements of the mechanical system which are described include viscoelastic buffers between impacting parts. Dead space or intermittent contact between parts is another aspect of the problem which is defined. The relationship between core flux and impressed current is established through an experimentally measured magnetization curve. Equations governing both the rise and fall of the magnetic flux are developed since a complete cycle of operation is under study. The resulting set of equations is nonlinear in nature and impractical to solve by hand. However, a systematic solution to the equations is readily obtained by numerical integration on a digital computer.
Frequency-dependent squeeze-amplitude attenuation and squeeze-angle rotation by electromagnetically induced transparency for gravitational-wave interferometers (2006)

We study the effects of frequency-dependent squeeze-amplitude attenuation and squeeze-angle rotation by electromagnetically induced transparency (EIT) on gravitational-wave (GW) interferometers. We propose the use of low-pass, bandpass, and high-pass EIT filters, an S-shaped EIT filter, and an intracavity EIT filter to generate frequency-dependent squeezing for injection into the antisymmetric port of GW interferometers. We find that the EIT filters have several advantages over the previous filter designs with regard to optical losses, compactness, and the tunability of the filter linewidth.
Near-infrared Spectral tomography system for measuring dynamic vascular changes in breast (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Jiang, B. W. Pogue, C. M. Carpenter, P. Kaufman, and K. D. Paulsen, "Near-infrared Spectral tomography system for measuring dynamic vascular changes in breast," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper BSuB6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Functional Interplay Between Nuclear Factor‐κB and c‐Jun Integrated by Coactivator p300 Determines the Survival of Nerve Growth Factor‐Dependent PC12 Cells (2000)

Abstract: Nerve growth factor (NGF) activates the transcription factors nuclear factor κB (NF‐κB) and activator protein‐1 (AP‐1) in sympathetic neurons. Whereas NGF‐inducible NF‐κB is required for the survival of neurons, c‐Jun has the ability to promote neuronal death. In this report, we have examined the effect of NGF withdrawal on c‐Jun and NF‐κB transcription factors in PC12 cells differentiated to a neuronal phenotype. We show that the withdrawal of NGF from these cultures results in de novo synthesis of c‐Jun, increase in AP‐1 activity, and down‐regulation of NF‐κB activity. To investigate how the signal transduction pathways activating c‐Jun and NF‐κB are differentially regulated by NGF, we performed transcriptional analyses. Expression of RelA (NF‐κB) suppressed the c‐Jun‐dependent transcription of c‐ jun , and this effect was reversed by overexpression of the coactivator p300. RelA’s effects on c‐Jun transcription were mediated by competitive binding of the carboxy‐terminal region of RelA to the CH1 domain of p300, which also binds to c‐Jun; deletion of this region abrogated the ability of RelA to inhibit c‐Jun activity. Furthermore, the inhibition of endogenous NF‐κB in NGF‐maintained neuronal PC12 cells led to the induction of c‐Jun synthesis and a marked increase in cell death. Together, these studies demonstrate a functional interaction between NF‐κB and c‐Jun and suggest a novel mechanism of NF‐κB‐mediated neuroprotection.
Supplemental Figure 3 from Baseline Plasma Tumor Mutation Burden Predicts Response to Pembrolizumab-based Therapy in Patients with Metastatic Non–Small Cell Lung Cancer (2023)

&lt;p&gt;pTMBand PD-L1 expression levels.&lt;/p&gt;
Concept Maps for Personalizked Interest Management. (2009)

To assist users to access wanted services and information within a short attention span, personalization has gained tremendous importance. While systems such as recommenders for specific domains have been successfully deployed, there is no existing user-centric mechanism that can be utilized for all application domains. By capturing user’s interests and relationships among such interests, it is possible to provide personalization for a wide range of applications. In this paper, we present our initial investigations in constructing concept maps for user interest management. Based on common sense, we have attempted to build a generic concept map that can be utilized for recommendation purposes to address the cold-start problem. We have also presented our experiment in generating personal concept maps, that are derived purely based on data corresponding to a particular user. Our aim is to create a platform for personalized interest management. We provide our observations, challenges and insights based on our experience.
Horizons in Tumor Immunology (1974)

Dr. Wilson: Although we really have to thank the Gordon Conference for attracting two of our three speakers to Boston this morning, we are pleased to have them under any circumstances because we are excited about this seminar. I have entitled the seminar "Horizons in Tumor Immunology" because I hope the speakers will be presenting a synthesis of new ideas rather than any large series of treated patients. Immunotherapy is not really a new concept, but lately it has gained perspective and prominence. Contributing to this increase in interest has been the growing sophistication of investigations on many fronts and many disciplines; evidence of our capability to perform immune manipulation, particularly in the field of transplantation; and, finally, the realization that more aggressive surgery does not necessarily produce higher cure rates in cancer. Immunotherapy offers the chance to destroy the last remaining tumor cell. Our approach here at the Peter
PCEP Extension for Stateful Inter-Domain Tunnels (2020)

This document proposes to combine a Backward Recursive or Hierarchical
method in Stateful PCE with PCInitiate message to setup independent
paths per domain, and combine these different paths together in order
to operate them as end-to-end inter-domain paths without the need of
signaling session between AS border routers. A new Stitching Label is
defined, new Path Setup Types and a new Association Type are
considered for that purpose.
VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo (2020)

Therapeutically targeting CD138, a define multiple myeloma (MM) antigen, is not yet approved for patients. We here developed and determined the preclinical efficacy of VIS832, a novel therapeutic monoclonal antibody (MoAb) with differentiated CD138 target binding to BB4 that is anti-CD138 MoAb scaffold for indatuximab ravtansine (BT062). VIS832 demonstrated enhanced CD138-binding avidity and significantly improved potency to kill MM cell lines and autologous patient MM cells regardless of resistance to current standard-of-care therapies, via robust antibody-dependent cellular cytotoxicity and phagocytosis mediated by NK and macrophage effector cells, respectively. Specifically, CD38-targeting daratumumab-resistant MM cells were highly susceptible to VIS832 which, unlike daratumumab, spares NK cells. Superior maximal cytolysis of VIS832 vs. daratumumab corresponded to higher CD138 vs. CD38 levels in MM cells. Furthermore, VIS832 acted synergistically with lenalidomide or bortezomib to deplete MM cells. Importantly, VIS832 at a sub-optimal dose inhibited disseminated MM1S tumors in vivo as monotherapy (P < 0.0001), and rapidly eradicated myeloma burden in all mice concomitantly receiving bortezomib, with 100% host survival. Taken together, these data strongly support clinical development of VIS832, alone and in combination, for the therapeutic treatment of MM in relapsed and refractory patients while pointing to its potential therapeutic use earlier in disease intervention.
Evaluation of renal parenchymal disease in a rat model with magnetic resonance elastography (2004)

Alterations in the mechanical properties or "hardness" of tissues allow physicians to detect disease by palpation. Recently, attempts have been made to quantitate and image these tissue properties with the use of magnetic resonance elastography (MRE). This technique has been validated in ex vivo specimens, including kidney, breast, and prostate. In this study, in vivo MRE imaging of rat renal cortex is demonstrated and validated with a disease model that will facilitate further studies. Normal rats and rats with nephrocalcinosis induced with either 2 or 4 weeks of ethylene glycol exposure were studied with MRE. Histology in the diseased rats documented the presence of nephrocalcinosis. MRE measurements and images of shear stiffness were highly reproducible in individual rats. The shear stiffness of the renal cortex in normal rats was 3.87 kPa (95% CI 2.84-4.90 kPa). The shear stiffness increased to 5.02 kPa (95% CI 3.34-6.70 kPa) after 2 weeks of exposure, and to 6.49 kPa (95% CI 4.84-8.14 kPa) after 4 weeks of exposure (P = 0.0302, alpha < 0.05). MRE is capable of detecting alterations in the tissue mechanical properties of kidneys in vivo. It is a promising noninvasive technique that might have pathologic and prognostic significance.
Hydrofluoric Acid Etching of Silicon Dioxide Sacrificial Layers: I . Experimental Observations (1994)

The key process in silicon surface micromachining is the selective etching of silicon dioxide sacrificial layers with hydrofluoric acid. This paper discusses experimental sacrificial layer etching results. The etching reaction shifts from kinetic controlled to diffusion controlled as the etch channel dissolves. Test structures consist of several low pressure chemical vapor deposited (LPCVD) phosphosilicate glass (PSG) isolated etch channels having widths ranging from 2 to 50 μm underneath transparent silicon‐rich LPCVD silicon nitride or thin (1500 Å) LPCVD polycrystalline silicon structural layers. Etching is monitored at timed intervals through this structural layer. Diffusion‐limitations are observed at long times. After 20 min in concentrated , etch fronts have moved 25% less than the initial etch rate would suggest. In addition, increasing the phosphorus content in PSG thin films, increasing the concentration, and the addition of to solutions increases the initial etch rate of silicon dioxide sacrificial layers. Buffered and surfactant buffered did not enhance the etching of silicon dioxide sacrificial layers. The addition of fluosilicic acid to decreased the initial etch rate of silicon dioxide but did not affect the diffusion rate of in water for low concentrations of . Etch channel width, sacrificial layer thickness, structural material choice and stress condition, and applied stress did not affect the sacrificial layer etch process rate.
Bias Temperature Instability Reliability in Stacked Gate-All-Around Nanosheet Transistor (2019)

In this paper, we report the bias temperature instability (BTI) reliability in stacked gate-all-around (GAA) nanosheet (NS) devices. We show that, in addition to its superior intrinsic performance over FinFET and stacked nanowire (NW), stacked NS can also provide NBTI reliability benefit, owing to domination of (100) surface conduction and mitigation of field enhancement effect in ultra-scaled GAA structure.
Metadynamics as a Postprocessing Method for Virtual Screening with Application to the Pseudokinase Domain of JAK2 (2020)

With standard scoring methods, top-ranked compounds from virtual screening by docking often turn out to be inactive. For this reason, metadynamics, a method used to sample rare events, was studied to further evaluate docking poses with the aim of reducing false positives. Specifically, virtual screening was performed with Glide SP to seek potential molecules to bind to the ATP site in the pseudokinase domain of JAK2 kinase, and promising compounds were selected from the top-ranked 1000 based on visualization. Rescoring with Glide XP, GOLD, and MM/GBSA was unable to differentiate well between active and inactive compounds. Metadynamics was then used to gauge the relative binding affinity from the required time or the potential of mean force needed to dissociate the ligand from the bound complex. With consideration of previously known binders of varying affinities, metadynamics was able to differentiate between the most active compounds and inactive or weakly active ones, and it could identify correctly most of the selected virtual screening compounds as false positives. Thus, metadynamics has the potential to be a viable postprocessing method for virtual screening, minimizing the expense of buying or synthesizing inactive compounds.
HLA class II alleles and haplotypes are associated to the presence autoantibodies and mortality in Hypersensitivity Pneumonitis patients. (2018)

<b>Background:</b> In the last years it has been shown a subgroup of patients with hypersensitivity pneumonitis (HP) that develop autoantibodies with or without clinical manifestations of autoimmune disease. Factors involved in this process, and the effect of these autoantibodies on clinical course and mortality are unknown. <b>Aim:</b> To evaluate association between HLA class II alleles and HP patients with and without autoantibodies. Methods: 170 patients with confirmed diagnosis of HP were included. Autoimmune laboratory profile included ANA, RF, anti-SSA/Ro, anti-SSB/La, anti-Scl70 and anti-CCP. HLA typing was performed by PCR-SSP in a high-resolution modality, including HLA-DRB1 and HLA-DQB1 loci. Statistical analysis was performed employing EPI-info v7 and SPSSv20. <b>Results:</b> Sixty HP patients developed sera autoantibodies (HPAb+; 50 females; 53.4±9.3 years) and 110 HP patients did not (HP; 84 females; 52.5±11.8 years). The frequency of the allele HLA-DRB1*03 was remarkably increased in the HPAb+ group (10.8% <i>vs</i>. 0.45%; OR=26.6, CI95% 3.0-206.8 p=8.26E-06). Likewise, the loci HLA-DQB1*02:01 and DQB1*06:01 frequencies were almost three-fold higher in the HPAb+ group [(15.0% versus 6.4%, OR=2.59, CI95% 1.24-5.42; p=7.7E-03) and (12.5% <i>vs</i>. 4.5%, OR=3.33, CI95% 1.30-6.90 p=6.8E-03)]. Regarding the haplotypes, DRB1*03-DQB1*02:01 showed a significant difference (OR=17.75, CI95% 2.22-141.9 p=0.0004). Mortality was associated to the HLA-DRB1*03 allele (p=0.004, β=0.225, CI95% 0.098-0.505). Conclusions: A subset of HP patients present circulating autoantibodies which is associated, at least partially, to some variants of the HLA, increasing the risk for death.
PD23-06 OUTCOME OF MINI-PCNL VERSUS EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY IN TREATMENT OF SINGLE LOWER CALYCEAL STONE 10-20MM WITH FAVORABLE LOWER CALYCEAL ANATOMY: A PROSPECTIVE RANDOMIZED STUDY (2016)

INTRODUCTION AND OBJECTIVES: Real-time virtual sonography (RVS) is a diagnostic imaging support system that can be synchronized with real-time ultrasonography in conjunction with computed tomography (CT) using a magnetic navigation system. The application of RVS for percutaneous nephrolithotomy has not yet been reported. This study aimed to examine the effect of RVS-guided renal access during endoscopic combined intrarenal surgery (ECIRS) for large renal calculi.
Fabrication of Thin‐Film SrCe 0.9 Eu 0.1 O 3−δ Hydrogen Separation Membranes on Ni–SrCeO 3 Porous Tubular Supports (2009)

SrCe 0.9 Eu 0.1 O 3−δ thin‐film (∼30 μm) tubular hydrogen separation membranes were developed in order to obtain high hydrogen fluxes. Fifteen centimeters long, one end closed, NiO–SrCeO 3 tubular supports were fabricated by tape casting, followed by rolling the green tape on a circular rod. SrCe 0.9 Eu 0.1 O 3−δ powders were prepared by the citrate process and coated on partially sintered NiO–SrCeO 3 tubular supports. Leakage‐free hydrogen membrane cells were obtained by adjusting the presintering and final sintering temperatures to reduce the difference of linear shrinkage rates between SrCe 0.9 Eu 0.1 O 3−δ thin films and NiO–SrCeO 3 supports. A hydrogen flux of 2.2 cm 3 /min was obtained for the SrCe 0.9 Eu 0.1 O 3−δ on Ni–SrCeO 3 tubular hydrogen separation membranes at 900°C using 25% H 2 balanced with Ar and 3% H 2 O as the feed gas and He as the sweep gas. Thus, a 40% single pass yield of pure H 2 was achieved with this membrane.
Modelling of note events for singing transcription. (2004)

This paper concerns the automatic transcription of music and proposes a method for transcribing sung melodies. The method produces symbolic notations (i.e., MIDI files) from acoustic inputs based on two probabilistic models: a note event model and a musicological model. Note events are described with a hidden Markov model (HMM) using four musical features: pitch, voicing, accent, and metrical accent. The model uses these features to calculate the likelihoods of different notes and performs note segmentation. The musicological model applies key estimation and the likelihoods of two-note and three-note sequences to determine transition likelihoods between different note events. These two models form a melody transcription system with a modular architecture which can be extended with desired front-end feature extractors and musicological rules. The system transcribes correctly over 90 % of notes, thus halving the amount of errors compared to a simple rounding of pitch estimates to the nearest MIDI note. 1.
<title>A fast video clip retrieval algorithm based on VA-file</title> (2003)

Video clip retrieval is a significant research topic of content-base multimedia retrieval. Generally, video clip retrieval process is carried out as following: (1) segment a video clip into shots; (2) extract a key frame from each shot as its representative; (3) denote every key frame as a feature vector, and thus a video clip can be denoted as a sequence of feature vectors; (4) retrieve match clip by computing the similarity between the feature vector sequence of a query clip and the feature vector sequence of any clip in database. To carry out fast video clip retrieval the index structure is indispensable. According to our literature survey, S<sup>2</sup>-tree [17] is the one and only index structure having been applied to support video clip retrieval, which combines the characteristics of both X-tree and Suffix-tree and converts the series vectors retrieval to string matching. But S<sup>2</sup>-tree structure will not be applicable if the feature vector's dimension is beyond 20, because the X-tree itself cannot be used to sustain similarity query effectively when dimensions of vectors are beyond 20. Furthermore, it cannot support flexible similarity definitions between two vector sequences. VA-file represents the vector approximately by compressing the original data and it maintains the original order when representing vectors in a sequence, which is a very valuable merit for vector sequences matching. In this paper, a new video clip similarity model as well as video clip retrieval algorithm based on VA-File are proposed. The experiments show that our algorithm incredibly shortened the retrieval time compared to sequential scanning without index structure.
Switched reluctance motor drive without direct rotor position sensing (2002)

A closed loop control technique based on monitoring phase current risetime for switched reluctance (SR) motors without direct rotor-position sensors has been studied and implemented successfully. In this technique the variation in incremental phase inductance in a SR motor is used to detect rotor position. A control circuit for current-waveform-based rotor position detection has been implemented using hard-wire digital circuits. Torque-speed and system-efficiency characteristics resulting from the application of the method to a 4 kW, four-phase SR motor with an IGBT drive are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>