gebhart/patrepeval huggingface dataset:
Requirements for T Lymphocyte Migration in Explanted Lymph Nodes (2007)

Although the requirements for T lymphocyte homing to lymph nodes (LNs) are well studied, much less is known about the requirements for T lymphocyte locomotion within LNs. Imaging of murine T lymphocyte migration in explanted LNs using two-photon laser-scanning fluorescence microscopy provides an opportunity to systematically study these requirements. We have developed a closed system for imaging an intact LN with controlled temperature, oxygenation, and perfusion rate. Naive T lymphocyte locomotion in the deep paracortex of the LN required a perfusion rate of >13 microm/s and a partial pressure of O(2) (pO(2)) of >7.4%. Naive T lymphocyte locomotion in the subcapsular region was 38% slower and had higher turning angles and arrest coefficients than naive T lymphocytes in the deep paracortex. T lymphocyte activation decreased the requirement for pO(2), but also decreased the speed of locomotion in the deep paracortex. Although CCR7(-/-) naive T cells displayed a small reduction in locomotion, systemic treatment with pertussis toxin reduced naive T lymphocyte speed by 59%, indicating a contribution of Galpha(i)-mediated signaling, but involvement of other G protein-coupled receptors besides CCR7. Receptor knockouts or pharmacological inhibition in the adenosine, PG/lipoxygenase, lysophosphatidylcholine, and sphingosine-1-phosphate pathways did not individually alter naive T cell migration. These data implicate pO(2), tissue architecture, and G-protein coupled receptor signaling in regulation of naive T lymphocyte migration in explanted LNs.
Experimental validation of systematically designed acoustic hyperbolic meta material slab exhibiting negative refraction (2016)

This Letter reports on the experimental validation of a two-dimensional acoustic hyperbolic metamaterial slab optimized to exhibit negative refractive behavior. The slab was designed using a topology optimization based systematic design method allowing for tailoring the refractive behavior. The experimental results confirm the predicted refractive capability as well as the predicted transmission at an interface. The study simultaneously provides an estimate of the attenuation inside the slab stemming from the boundary layer effects—insight which can be utilized in the further design of the metamaterial slabs. The capability of tailoring the refractive behavior opens possibilities for different applications. For instance, a slab exhibiting zero refraction across a wide angular range is capable of funneling acoustic energy through it, while a material exhibiting the negative refractive behavior across a wide angular range provides lensing and collimating capabilities.
The role of ATM and 53BP1 as predictive markers in cervical cancer (2012)

Treatment of advanced-stage cervical cancers with (chemo)radiation causes cytotoxicity through induction of high levels of DNA damage. Tumour cells respond to DNA damage by activation of the 'DNA damage response' (DDR), which induces DNA repair and may counteract chemoradiation efficacy. Here, we investigated DDR components as potential therapeutic targets and verified the predictive and prognostic value of DDR activation in patients with cervical cancer treated with (chemo)radiation. In a panel of cervical cancer cell lines, inactivation of ataxia telangiectasia mutated (ATM) or its substrate p53-binding protein-1 (53BP1) clearly gave rise to cell cycle defects in response to irradiation. Concordantly, clonogenic survival analysis revealed that ATM inhibition, but not 53BP1 depletion, strongly radiosensitised cervical cancer cells. In contrast, ATM inhibition did not radiosensitise non-transformed epithelial cells or non-transformed BJ fibroblasts. Interestingly, high levels of active ATM prior to irradiation were related with increased radioresistance. To test whether active ATM in tumours prior to treatment also resulted in resistance to therapy, immunohistochemistry was performed on tumour material of patients with advanced-stage cervical cancer (n = 375) treated with (chemo)radiation. High levels of phosphorylated (p-)ATM [p = 0.006, hazard ratio (HR) = 1.817] were related to poor locoregional disease-free survival. Furthermore, high levels of p-ATM predicted shorter disease-specific survival (p = 0.038, HR = 1.418). The presence of phosphorylated 53BP1 was associated with p-ATM (p = 0.001, odds ratio = 2.206) but was not related to any clinicopathological features or survival. In conclusion, both our in vitro and patient-related findings indicate a protective role for ATM in response to (chemo)radiation in cervical cancer and point at ATM inhibition as a possible means to improve the efficacy of (chemo)radiation.
The Transition to Family Caregiving: Does It Affect Biomarkers of Aging? (2020)

Abstract Blood samples were collected from participants in the REGARDS study on two separate occasions. No participants in the Caregiving Transitions Study were caregivers at the first blood draw, but 251 became caregivers before the second blood draw 9 years later. These caregivers were matched with 251 noncaregiving controls. Six circulating biomarkers of inflammation (e.g., CRP, IL-6, TNFR1) and a measure of cellular aging (leukocyte telomere length) were assessed at both blood draws. All biomarkers except CRP showed overall aging effects (ps &amp;lt; 0.001). Caregivers had a small but significantly greater increase in TNFR1 levels (p = 0.03) than controls, but no significant differential changes were found on the other 5 inflammatory biomarkers or on telomere length. Preliminary findings from latent variable models indicated good model fit and found caregivers to be 0.27 SDs lower than controls on a latent construct of inhibitory, regulatory feedback of systemic inflammation (p = 0.03).
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons (2016)

Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration tauopathy (FTLD-Tau), which presents with dementia and is characterized by atrophy in the frontal and temporal lobes of the brain. Although induced pluripotent stem cell (iPSC) technology has facilitated the investigation of phenotypes of FTLD-Tau patient neuronal cells in vitro, it remains unclear how FTLD-Tau patient neurons degenerate. Here, we established neuronal models of FTLD-Tau by Neurogenin2-induced direct neuronal differentiation from FTLD-Tau patient iPSCs. We found that FTLD-Tau neurons, either with an intronic MAPT mutation or with an exonic mutation, developed accumulation and extracellular release of misfolded tau followed by neuronal death, which we confirmed by correction of the intronic mutation with CRISPR/Cas9. FTLD-Tau neurons showed dysregulation of the augmentation of Ca<sup>2+</sup> transients evoked by electrical stimulation. Chemogenetic or pharmacological control of neuronal activity-relevant Ca<sup>2+</sup> influx by the introduction of designer receptors exclusively activated by designer drugs (DREADDs) or by the treatment with glutamate receptor blockers attenuated misfolded tau accumulation and neuronal death. These data suggest that neuronal activity may regulate neurodegeneration in tauopathy. This FTLD-Tau model provides mechanistic insights into tauopathy pathogenesis and potential avenues for treatments.
Overview of narrowband IoT in LTE Rel-13 (2016)

In 3GPP Rel-13, a narrowband system, named Narrowband Internet of Things (NB-IoT), has been introduced to provide low-cost, low-power, wide-area cellular connectivity for the Internet of Things. This system, based on Long Term Evolution (LTE) technology, supports most LTE functionalities albeit with essential simplifications to reduce device complexity. Further optimizations to increase coverage, reduce overhead and reduce power consumption while increasing capacity have been introduced as well. The design objectives of NB-IoT include low-complexity devices, high coverage, long device battery life, and massive capacity. Latency is relaxed although a delay budget of 10 seconds is the target for exception reports. This paper provides an overview of NB-IoT design, including salient features from the physical and higher layers. Illustrative results with respect to performance objectives are also provided. Finally, NB-IoT enhancements in LTE Rel-14 are briefly outlined.
Komplexchemie reaktiver organischer Verbindungen, XXXIV. Einbau von Diazomethan in Mangan‐ und Rheniumcarbonyl‐Komplexe (1980)

Abstract Die Reaktionen von Pentacarbonylhydridomangan ( 1a ) bzw. ‐rhenium ( 1b ) mit Diazomethan führen unter Einbau des Diazoalkans zu den neuartigen Komplexverbindungen Mn 3 (CO) 12 ‐(N 2 CH 3 ) ( 3 ) sowie M 2 (CO) 10 (N 2 CH 2 ) ( 4a : MMn; 4b : MRe), in denen Diazomethan bzw. die Methandiazo‐Gruppierung komplexstabilisiert sind.
Electrolyte and Electrode Passivation for Thin Film Batteries (2000)

Passivation films for thin film batteries have been prepared and the conductivity and voltage stability window have been measured. Thin films of Li2CO3 have a large voltage stability window of 4.8V, which facilitates the use of this film as a passivation at both the lithium anode-electrolyte interface at high cathodic potentials The ionic conductivity of the Li~C03 films are rather low, 5 x lo- &amp;apos; Skm, which may be due to the nanocrystalline texture of the sputtered thin films. Sputtered films of Li2CO3 show evidence of Liz0 incorporation, which affects the air stability of the films. Sputtering at higher power levels attenuates the Li20, thus improving air stability of the as-deposited films.
Facile, palladium(II)-mediated synthesis of bridged and spirocyclic bicycloalkenones (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile, palladium(II)-mediated synthesis of bridged and spirocyclic bicycloalkenonesAndrew S. Kende, Bruce Roth, and Pauline J. SanfilippoCite this: J. Am. Chem. Soc. 1982, 104, 6, 1784–1785Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ja00370a076https://doi.org/10.1021/ja00370a076research-articleACS PublicationsRequest reuse permissionsArticle Views2210Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photoredox reactions using ion-exchange resin-adsorbed Ru(bpy)32+. Photosensitized reductions of methyl viologen and molecular oxygen using ion-exchange resin-adsorbed tris(2,2'-bipyridine)ruthenium(II) (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoredox reactions using ion-exchange resin-adsorbed Ru(bpy)32+. Photosensitized reductions of methyl viologen and molecular oxygen using ion-exchange resin-adsorbed tris(2,2'-bipyridine)ruthenium(II)Yoshimi Kurimura, Mitsunobu Nagashima, Kiyomi Takato, Eishun Tsuchida, Masao Kaneko, and Akira YamadaCite this: J. Phys. Chem. 1982, 86, 13, 2432–2437Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/j100210a037https://doi.org/10.1021/j100210a037research-articleACS PublicationsRequest reuse permissionsArticle Views344Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Robust Nonlinear Proportional-Integral Control for Active Braking Control Systems (2006)

In road vehicles, wheel locking can be avoided by means of electronic anti-lock braking systems (ABS). The main challenge in designing closed-loop braking controllers is the need to cope with unknown road conditions and consistent variations in the vertical load exerted on the tires during braking. In this work a nonlinear output feedback proportional integral control law for active braking control systems is proposed, which does not require any knowledge either of the current road condition or of the instantaneous value of the vertical load. This control law guarantees bounded control action and can cope also with input constraints. The design is performed via Lyapunov-based methods and its effectiveness is assessed via simulations
APOPTOTIC CELL DEATH IN HUMAN CHRONIC RENAL ALLOGRAFT REJECTION (1997)

Chronic renal allograft rejection is characterized by gradual progression suggesting persistent low-grade injury. Apoptotic cell death may be initiated by low-grade injury secondary to external factors, making apoptosis a potential pathway of chronic rejection. In the present investigation, protocol kidney biopsies of 20 pediatric renal allograft recipients (12 with chronic rejection and 8 with normal histology), 9 pediatric liver allograft recipients, and 7 children with minimal change nephrotic syndrome were evaluated. The presence of apoptotic cell death was studied by determining apoptosis-induced oligonucleosomal DNA fragmentation in the biopsy specimens using 3' end labeling with terminal transferase, gel fractionation, and Southern blotting. The specific cell types with increased DNA fragmentation were determined by in situ 3' end labeling performed on sections of the biopsies. Significant DNA fragmentation was found only in the specimens from patients with chronic rejection. In situ investigation revealed increased apoptosis of both proximal and distal tubular epithelial cells, but not in the glomeruli or interstitium. The mean number of apoptotic tubular epithelial cells per 400x magnified field was higher in the renal allografts than in kidneys of liver transplant recipients or patients with minimal change nephrotic syndrome (2.3 vs. 0.8, P<0.05, in both cases). Our data provide biochemical evidence of increased apoptotic cell death of renal tubular epithelial cells in patients undergoing chronic renal allograft rejection.
COMPARISONS BETWEEN DESIGNS FOR SINGLE-SIDED LINEAR ELECTRIC MOTORS: HOMOPOLAR SYNCHRONOUS AND INDUCTION. PHASE III (1980)

A design study of two types of single-sided (with a passive rail) linear electric machine designs, namely homopolar linear synchronous machines (LSM's) and linear induction machines (LIM's), is described. It is assumed the machines provide tractive effort for several types of light rail vehicles and locomotives. These vehicles are wheel supported and require tractive powers ranging from 200 kW to 3735 kW and top speeds ranging from 112 km/hr to 400 km/hr. All designs are made according to specified magnetic and thermal criteria. The LSM advantages are a higher power factor, much greater restoring forces for track misalignments, and less track heating. The LIM advantages are no need to synchronize the excitation frequency precisely to vehicle speed, simpler machine construction, and a more easily anchored track structure. The relative weights of the two machine types vary with excitation frequency and speed; low frequencies and low speeds favor the LSM. The effect of variations in several LSM design parameters are shown to illustrate trends in machine dimensions, track weight, and commutating reactance. The details of the LSM design programs are described and a Fortran IV listing of the programs is provided.
Highly absorbing superabsorbent polymer (2007)

Abstract Acrylic acid (AA)–acrylamide (AM) based superabsorbent polymers (SAP) were synthesized by inverse suspension polymerization using potassium‐persulfate as the initiator, N,N ′‐methylene bisacrylamide (BIS) as a crosslinker, sorbitan monostearate (Span 60) as the dispersant, cyclohexane as the solvent, and bis(methacryloylamino)‐azobenzene as the hydrophobic surface crosslinker. The influence of the polymerization parameters on the properties of the SAPs, water absorption ( Q ), morphology of the SAPs, swelling kinetics, salt resistance, and the reversibility of water absorption were investigated. The prepared SAPs have excellent water absorption, rapid water uptake, and good resistance to NaCl solutions. Furthermore, they show better reversible water uptake than the previously reported SAPs. The average water absorbency is 2800 g/g and 181 g/g of liquid absorbance in 0.025M NaCl solution. The initial water uptake rate is 1357 g/g/min and the reversibility of water absorption is 200 g/g in the repeated fourth cycle. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 1357–1364, 2008
Centers, Symbols, and Hierarchies: Essays on the Classical States of Southeast Asia. Edited by Lorraine Gesick. Foreword by Clifford Geertz. New Haven, Conn.: Yale University, 1983. (Southeast Asia Studies Monograph Series, no. 26.) x, 241 pp. $13 (paper). (1986)

Book Review| February 01 1986 Centers, Symbols, and Hierarchies: Essays on the Classical States of Southeast Asia Centers, Symbols, and Hierarchies: Essays on the Classical States of Southeast Asia. Edited by Lorraine Gesick. Foreword by Clifford Geertz. New Haven, Conn.: Yale University, 1983. (Southeast Asia Studies Monograph Series, no. 26.) x, 241 pp. $13 (paper). Kenneth R. Hall Kenneth R. Hall North Adams State College Search for other works by this author on: This Site Google Journal of Asian Studies (1986) 45 (2): 448–449. https://doi.org/10.2307/2055902 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Kenneth R. Hall; Centers, Symbols, and Hierarchies: Essays on the Classical States of Southeast Asia. Journal of Asian Studies 1 February 1986; 45 (2): 448–449. doi: https://doi.org/10.2307/2055902 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Asian Studies Search Advanced Search The text of this article is only available as a PDF. Copyright © Association for Asian Studies, Inc. 19861986 Article PDF first page preview Close Modal You do not currently have access to this content.
Semiconductor Photonic Crystal and Its Application. (2001)

A semiconductor photonic crystal and its application to functional devices are described. The main feature of the crystal is that it has a photonic band gap and we can realize various functions, such as waveguides, cavities and so on, only by introducing artificial defects in the crystal. As one of the examples, we describe here a trapping and emission of photons by a single defect in two-dimensional (2 D) photonic crystal slab. We show the tunability of trapping wavelength by defect engineering and the possibility to realize ultra-small channel drop filters for WDM optical communication system. As another example, we show the band edge engineering, where we demonstrate that 2 D coherent lasing oscillation can be achieved by using the 2 D photonic crystal.
Monocyclopentadienyltitanium Aryloxide Complexes:  Preparation, Characterization, and Application in Cyclization Reactions (2002)

A variety of monocyclopentadienyltitanium aryloxide complexes were prepared, characterized by X-ray crystallography, and used to catalyze or mediate cyclization reactions. Structural characterization allowed for the comparison of steric parameters of various 2,6-disubstituted aryloxide ligands. Transformations of dienes and enynesincluding the catalysis of a 1,6-diene cycloisomerization and the intramolecular Pauson−Khand reactionwere investigated. A titanium metallacycle was prepared from a sterically hindered enyne containing a trisubstituted olefin. The Pauson−Khand reaction of trimethylsilyl-substituted enynes was promoted to generate α-silylcyclopentenones.
A miniaturized optical sensor for particulate matter detection (2020)

We present an innovative optical particulate matter sensor. This optical sensor ‘on-a-chip’ combines a visible fibered light source and a custom-made CMOS image sensor chip. By illuminating a single particle in an air channel, we can record the light scattering signature on the photodiode matrix. A piece realized in 3D printing achieves fiber alignment and an efficient stray light protection. A specific scattering pattern occurs from the interaction of light with a single particle. Unlike traditional optical PM sensors based on a single photodiode detection, we measure a lens-free projection of the scattering signature on the nearby image sensor (1.5mm projection distance). This allows us to count particles and determine their size and refractive index. These parameters are retrieved through image processing and by comparison with a radiometric model that calculates the projection of a Lorenz-Mie’s scattering pattern. <br/> We describe the sensing technique, the architecture and fabrication of this sensor as well as the characterization results, which are in good agreement with our theory-based predictions. In particular, we show that it is possible to differentiate calibrated particulates of different sizes (monodisperse polystyrene-latex spheres). The sensor is sensitive enough to detect single particle and smallest than 1μm.
A study of dilatation and acoustic propagation in solidifying fats and oils: II. Experimental (1984)

Abstract Experimental evidence is presented to support the hypothesis that acoustic dilatation is linearly related to solid fat index dilation. This hypothesis is shown to be consistent with the measured temperature dependence of the dilation and ultrasonic velocity during solidification of palm oil, coconut oil, tristearin and a vegetable fat, all of which were diluted with triolein. The maximum solid content examined was 15%. The ultrasonic pulse echo method may provide a means of measuring the solid content of oils and of indicating the presence of phase transitions in the solid phase.