gebhart/patrepeval huggingface dataset:
ChemInform Abstract: New Halogenation Reagent System for One‐Pot Conversion of Alcohols into Iodides and Azides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
HGG-15. THE IMIPRIDONE ONC201 IN COMBINATION WITH THE ONCOLYTIC ADENOVIRUS DELTA-24-RGD HAS A SYNERGISTIC EFFECT IN PRECLINICAL MODELS OF PHGGS AND DMGS (2021)

Abstract Pediatric High Grade Gliomas (pHGGs), including Diffuse Midline Gliomas (DMGs), are aggressive pediatric tumors with a poor overall survival. In the last years, ONC201 has emerged as a promising agent in the field of pediatric brain tumors. Another interesting approach is virotherapy; Delta-24-RGD, which is an oncolytic virus, has demonstrated safety and effectiveness in different preclinical models and in clinical trials. Therefore, in this work we set to evaluate whether the combination of ONC201 with Delta-24-RGD could result in an increased therapeutic benefit in pHGGs and DMGs. Given that ONC201 targets mitochondrial metabolism in a preclinical setting, we assessed potential negative interactions of the combination therapy. While ONC201 treatment resulted in decreased viral protein load (E1A and fiber), there was no significant negative impact on the viral replication (measured by hexon staining). ONC201 did not disrupt the activation of mTORC1 pathway by the adenovirus. Furthermore, Delta-24-RGD did not affect the decrease in basal oxygen consumption rate induced by ONC201. Our results suggested that ONC201 and Delta-24-RGD are not antagonistic. Evaluation of the in vitro cytotoxicity in different human pHGG (CHLA-03-AA and SF188) and DMG (TP-54 and SU-DIPG-IV) cell lines showed that the combination treatment was significantly better that either agent alone. In vivo, a single local injection of Delta-24-RGD followed by a weekly ONC201 of mice bearing CHLA-03-AA cell line orthotopically significantly increased the median overall survival (PBS: 48 days; ONC201: 54.5 days; Delta-24-RGD: 62 days; ONC201+Delta-24-RGD: 95 days (P=0.0008)) of these mice leading to 20% long-term survivors, free of disease. Currently, we are evaluating the effect of the combination in immunosuppressed and immunocompetent models of DMGs. In summary, our data indicate ONC201 in combination with Delta-24-RGD could be a potential therapeutic choice for patients affected by pHGGs and DMGs.
Qualifying Image Quality from Pairwised Comparisons (1998)

The method of paired comparisons is one of the most common experiment techniques to quantify image quality. The common data analysis is the Thurstone's traditional procedure that assumes normal distribution and equal variance of observer judgments across the test samples. When the distributions of observer judgments are apparently unequal, less restrictive method should be used. However, most existing statistical procedures for the purpose are limited in practice to the data with complete pairwised comparisons and with no unanimous judgments. This paper describes a new procedure that can overcome the limitations. It utilizes linear regression and iterative error reduction techniques to directly estimate the standard deviations of observer judgments and the scale values of test samples without approximation.
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase (2004)

We report here the synthesis and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of several rationally-designed quindoline analogues, substituted at the 2- and 7- positions. The ability of these compounds to interact with and stabilise an intramolecular G-quadruplex DNA against increases in temperature was evaluated by a fluorescence-based (FRET) melting assay. The resulting T(m) values were found to correlate with their potency for telomerase inhibition, as measured in an in vitro telomerase TRAP assay. The interactions of a number of compounds with a quadruplex DNA molecular structure were simulated by molecular modelling methods. It is concluded that this class of compound represents a new chemical type suitable for further development as telomerase inhibitors.
Optimal Control of Hysteresis in Smart Actuators: A Viscosity Solutions Approach (2002)

Hysteresis in smart materials hinders their wider applicability in actuators.The low dimensional hysteresis models for these materials are hybrid systems with both controlled switching and autonomous switching.In particular, they belong to the class of Duhem hysteresis models and can be formulated as systems with both continuous and switching controls.In this paper, we study the control methodology for smart actuators through the example of controlling a commercially available magnetostrictive actuator.For illustrative purposes, an infinite horizon optimal control problem is considered.We show that the value function satisfies a Hamilton-Jacobi-Bellman equation (HJB) of a hybrid form in the viscosity sense.We further prove uniqueness of the viscosity solution to the (HJB), and provide a numerical scheme to approximate the solution together with a sub-optimal controller synthesis method.Numerical and experimental results based on this approach are presented.
Editorial: On our way towards self-adhesive restorative materials? (2019)

status: Accepted
Airway management and anesthetic considerations (2022)

Anesthesia and airway management for pediatric bronchoscopy are dynamic and collaborative, and require clinical expertise and familiarity with equipment in order to carry out the procedure safely and successfully. Location, timing, goals of the procedure, clinical condition of the patient, and a wide variety of options for airway and anesthetic management strategies are the most important factors to consider when performing pediatric bronchoscopy. Team-based decision making before and during the procedure, as well as goal-specific administration of medication and open communication among anesthesia and proceduralists are also vital factors for safety and success. This chapter reviews these and other relevant considerations for decision making with regard to pediatric bronchoscopy, a variety of airway management strategies, utilization of airway adjuncts and advanced airway equipment, anesthetic medications for bronchoscopy, and a team-based approach to shared airway management. Working knowledge of the above topics ensures a safe, efficient, and successful pediatric bronchoscopy. Pediatric bronchoscopy requires that all participants have working knowledge of their respective equipment and a flexible, tailored technique for the particular patient and the goals of the procedure. This requires a communicative team to act as one unit.
Ki-4(scFv)–ETA′, a new recombinant anti-CD30 immunotoxin with highly specific cytotoxic activity against disseminated Hodgkin tumors in SCID mice (2000)

The human lymphocyte activation marker CD30 is highly overexpressed on Hodgkin/Reed–Sternberg cells and represents an ideal target for selective immunotherapy. We used the murine anti-CD30 hybridoma Ki-4 to construct a new recombinant immunotoxin (rIT) for possible clinical use in patients with CD30+ lymphoma. Hybridoma V genes were polymerase chain reaction-amplified, assembled, cloned, and expressed as a mini-library for display on filamentous phage. Functional Ki-4 scFv obtained by selection of binding phage on the CD30-expressing Hodgkin lymphoma cell line L540cy was inserted into the bacterial expression vector pBM1.1 and fused to a deletion mutant ofPseudomonas exotoxin A (ETA′). Periplasmically expressed Ki-4(scFv)–ETA′ demonstrated specific activity against a variety of CD30+ lymphoma cells as assessed by different in vitro assays. To evaluate in vivo antitumor activity, severe combined immunodeficient mice challenged with human lymphoma cell lines were treated with the immunotoxin. The blood distribution time t½ of Ki-4(scFv)–ETA′ was 19 minutes, and its serum elimination time t½ was 193 minutes. A single intravenous injection of 40 μg rIT 1 day after tumor inoculation rendered 90% of the mice tumor free, extending the mean survival time to more than 200 days compared with 38.1 days in the phosphate-buffered saline control group (P &lt; .001). This new rIT is a promising candidate for further clinical evaluation in patients with Hodgkin lymphoma or other CD30+malignancies.
Over 30 000 h Device Lifetime in Deep Blue Organic Light‐Emitting Diodes with y Color Coordinate of 0.086 and Current Efficiency of 37.0 cd A−1 (2021)

Abstract The development of highly efficient and long‐life deep blue devices has been an ongoing challenge in the field of organic light‐emitting diodes (OLEDs) because of the short lifetime inherent to highly efficient blue devices. The efficiency and lifetime issues of the deep blue OLEDs are resolved in this work by engineering the device architecture by managing the triplet excitons of the phosphorescence and thermally activated delayed fluorescence (TADF) emitters. The CN‐modified imidazole type Ir emitter and boron‐based TADF emitter with similar emission energy are combined to develop an energy exchanging phosphorescence and TADF (EPHTADF) device. An emission mechanism inducing both forward and backward energy transfer concurrently between the Ir phosphor and TADF emitter shortens the triplet exciton lifetime of the two emitters, which dramatically enhances the device lifetime of the blue devices. Deep blue OLEDs triggering EPHTADF emission ultimately yields device performances including high current efficiency (CE) of 37.0 cd A −1 , color‐coordinate corrected CE of 430.9 cd A −1 , extrapolated device lifetime of more than 30 000 h, and deep blue color coordinates of (0.122, 0.086). This work demonstrates the potential of EPHTADF devices to serve as the solution to the problematic issues of the blue OLEDs.
Implementation of the IMEC-cleaning in advanced CMOS manufacturing (2023)

This paper is a review of the IMEC-cleaning. The fundamental physical and chemical principles for the basis of the IMEC-cleaning concept are described, which involves first of all, the removal of particles by breaking the van der Waals force by undercutting the particles and creating a repulsive zeta potential between the particle and the surface; secondly, removing the metal contamination from the surface using low pH mixtures; and finally, drying the surface after wet treatment with a Marangoni drying technique, which results in a very thin residual water layer. This IMEC-cleaning has been used in an IC (Integrated Circuit) prototype line and data over a period of 2 years are presented. The particle removal efficiency for several types of particles and surfaces is usually above 99%. The metal contamination is below 1. 1010 at.cm−2. The defect density of a gate oxide of 5.8 nm is well below 1 defect.cm−2 over several runs. And the cost of this IMEC-cleaning is lower than the more conventional cleaning techniques.
Effects of Osteogenic-Conditioned Medium from Human Periosteum-Derived Cells on Osteoclast Differentiation (2017)

Stem/progenitor cell-based regenerative medicine using the osteoblast differentiation of mesenchymal stem cells (MSCs) is regarded as a promising approach for the therapeutic treatment of various bone defects. The effects of the osteogenic differentiation of stem/progenitor cells on osteoclast differentiation may have important implications for use in therapy. However, there is little data regarding the expression of osteoclastogenic proteins during osteoblastic differentiation of human periosteum-derived cells (hPDCs) and whether factors expressed during this process can modulate osteoclastogenesis. In the present study, we measured expression of RANKL in hPDCs undergoing osteoblastic differentiation and found that expression of <i>RANKL</i> mRNA was markedly increased in these cells in a time-dependent manner. RANKL protein expression was also significantly enhanced in osteogenic-conditioned media from hPDCs undergoing osteoblastic differentiation. We then isolated and cultured CD34+ hematopoietic stem cells (HSCs) from umbilical cord blood (UCB) mononuclear cells (MNCs) and found that these cells were well differentiated into several hematopoietic lineages. Finally, we co-cultured human trabecular bone osteoblasts (hOBs) with CD34+ HSCs and used the conditioned medium, collected from hPDCs during osteoblastic differentiation, to investigate whether factors produced during osteoblast maturation can affect osteoclast differentiation. Specifically, we measured the effect of this osteogenic-conditioned media on expression of osteoclastogenic markers and osteoclast cell number. We found that osteoclastic marker gene expression was highest in co-cultures incubated with the conditioned medium collected from hPDCs with the greatest level of osteogenic maturation. Although further study will be needed to clarify the precise mechanisms that underlie osteogenic-conditioned medium-regulated osteoclastogenesis, our results suggest that the osteogenic maturation of hPDCs could promote osteoclastic potential.
0021 Lower Oxygen Saturation During Sleep Is Associated With Reduced Expressions Of Cd1d And Rab20 That Is Potentially Reversed By CPAP Therapy (2019)

Obstructive Sleep Apnea (OSA) is associated with a wide range of physiological changes, many of which are secondary to overnight hypoxemia. Prior associations studies of OSA and gene expression in blood were performed in small, clinic based samples. Here we study OSA and hypoxemia-related gene expression associations in large population-based studies, and in a small sample of individuals with OSA before and after treatment using continuous positive airway pressure (CPAP) who participated in the Heart Biomarkers in Apnea Treatment Study (HeartBEAT). We performed discovery analysis in two population-based studies: the Multi-Ethnic Study of Atherosclerosis (MESA; N = 580), and the Framingham Heart Study (FHS; N=571). We studied the association of gene expression in blood with three correlated traits that characterize the severity of OSA: the Apnea Hypopnea Index (AHI), defined as the number of apnea and hypopnea events accompanied by oxygen desaturation of at least 3% experienced per hour of sleep; average oxygen saturation (AveO2); and minimum oxygen saturation (minO2) during sleep. Associations with FDR q-value<0.05 in one study and p-value<0.05 in the other study, or with FDR q-value<0.05 in a meta-analysis of FHS and MESA, were then tested for gene expression change in the blood of 15 participants from the HeartBEAT study who had moderate or severe OSA and were studied before and after three months of treatment with CPAP. We identified 22 genes associated with OSA traits in both MESA and FHS, with most associations observed in AveO2 and minO2. Two of these genes further showed evidence of change with treatment in HeartBEAT: Lower CD1D and RAB20 expressions were associated with lower AveO2 in MESA and FHS, and CPAP therapy increased their expression in HeartBEAT. Gene expressions in CD1D and RAB20 were associated with OSA traits and appear to respond to CPAP therapy. CD1D encodes the CD1d antigen, and is associated with autoimmune diseases; RAB20 is a GTPase enzyme which is a Hypoxia-inducible transcription factor (HIF) target. R35 HL135818.
Scanning-free imaging through a single fiber by random spatio-spectral encoding (2015)

We present an approach for 2D imaging through a single fiber without the need for scanners. A random scattering medium placed next to the distal end of the fiber is used to encode the collected light from every imaged pixel with a different random spectral signature. We demonstrate imaging of externally illuminated 2D objects from a single measured spectrum at the fiber's proximal end. The technique is insensitive to fiber bending, an advantage for endoscopic applications.
Light emission from different ZnO junctions and nanostructures [Phys. Status Solidi A 206, No. 5, 853–859 (2009)] (2011)

One of the authors' names was misprinted. “N. S. Vonorova” should read correctly N. S. Voronova. The correct name of the author is indicated here.
Maximum Entropy Models, Dynamic Games, and Robust Output Feedback Control for Nonlinear Systems (2006)

In this paper, we develop a framework for designing controllers for general, partially observed discrete-time nonlinear systems which are robust with respect to uncertainties (disturbances). A general deterministic model for uncertainties is introduced, leading to a dynamic game formulation of the robust control problem. This problem is solved using an appropriate information state. We derive a partially observed nonlinear stochastic model as the maximum entropy stochastic model for the nonlinear system. A risk-sensitive stochastic control problem is formulated and solved for this partially observed stochastic model. The two problems are related using small noise limits. These small noise asymptotics are for the first time justified as the appropriate randomization, using time asymptotics of the Lagrange multipliers involved in the maximum entropy model construction. Thus for the first time a complete unification of deterministic and randomized uncertainty models is achieved. Various interpretations, consequences and applications of this unification are explained and discussed
Analysis of the tuning sensitivity of silicon-on-insulator optical ring resonators (2005)

High-quality-factor optical ring resonators have recently been fabricated in thin silicon-on-insulator (SOI). Practical applications of such devices will require careful tuning of the precise location of the resonance peaks. In particular, one often wants to maximize the resonance shift due to the presence of an active component and minimize the resonance shift due to temperature changes. This paper presents a semianalytic formalism that allows the prediction of such resonance shifts from the waveguide geometry. This paper also presents the results of experiments that show the tuning behavior of several ring resonators and find that the proposed semianalytic formalism agrees with the observed behavior.
Single neuron electrophysiology of transcranial magnetic stimulation. I. Passive responses (2010)

Transcranial magnetic stimulation (TMS) is a widely used noninvasive stimulation technique that induces neurons to discharge via a rapidly changing magnetic field directed through the scalp. However, the interaction between neural tissue and TMS stimulation is not well understood. Kamitani et al. [1] and Miyawaki et al. [2] have investigated the afterhyperpolarization that follows TMS evoked discharge in a single cortical neuron model, but they described only the discharge response and silent period evoked by a single TMS stimulus without details as to the orientation of the stimulating E-field. We have previously reported that spiking is induced only when the primary electric (E) field is oriented from the soma toward the apical dendrite (antidromic stimulus). In contrast, an E-field oriented in the opposite direction from the apical dendrite toward the soma (orthodromic stimulus) evokes an excitatory potential (EP) considerably larger (3 mV) than that of an excitatory postsynaptic potential (about 0.75 mV at -70 mV resting potential in this system) [4]. The EP is not sufficient to induce cell firing [4]. To better understand this behavior, we explored the passive membrane response of the model system to different stimulus magnitudes.
Wide-Angle Spectrally Selective Absorbers and Thermal\nEmitters Based on Inverse Opals (2019)

Engineered optical absorbers are of substantial interest for applications\nranging from stray light reduction to energy conversion. We demonstrate a\nlarge-area (centimeter-scale) metamaterial that features near-unity\nfrequency-selective absorption in the mid-infrared wavelength range. The\nmetamaterial comprises a self-assembled porous structure known as an inverse\nopal, here made of silica. The structure's large volume fraction of voids,\ntogether with the vibrational resonances of silica in the mid-infrared spectral\nrange, reduce the metamaterial's refractive index to close to that of air and\nintroduce considerable optical absorption. As a result, the frequency-selective\nstructure efficiently absorbs incident light of both polarizations even at very\noblique incidence angles. The absorber remains stable at high temperatures\n(measured up to ~900 degrees C), enabling its operation as a\nfrequency-selective thermal emitter. The excellent performance of this\nabsorber/emitter and ease of fabrication make it a promising surface coating\nfor passive radiative cooling, laser safety, and other large-area applications.\n
Site-specific programming of the host epithelial transcriptome by the gut microbiota (2015)

Our study indicates that the microbiota engage different regulatory networks to alter host gene expression in a particular niche. Understanding host-microbiota interactions on a cellular level may facilitate signaling pathways that contribute to health and disease and thus provide new therapeutic strategies.
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. (1995)

Farnesylation of the oncoprotein Ras is required for its cancer-causing activity. We have designed farnesyltransferase inhibitor (FTI)-276, a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B, as a highly potent and selective inhibitor of Ras farnesylation in vitro and in vivo. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene. Inhibition of tumor growth in vivo was dose dependent and correlated with inhibition of Ras processing in tumors in vivo. The work described here identifies FTI-276 as a highly selective suppressor of Ras-dependent oncogenicity and suggests that a broad spectrum of human cancers with aberrant Ras function could benefit from farnesyltransferase inhibitor treatment.