gebhart/patrepeval huggingface dataset:
Performance evaluation of the CCSDS file delivery protocol - latency and storage requirement (2005)

To support robotic and human explorations of Mars in the coming decade, the 2005 Mars Reconnaissance Orbiter (MRO) and the 2009 Mars Telecommunications Orbiter (MTO), as part of the Mars Network, will provide file transfer services to other Marscrafts using the CCSDS File Delivery Protocol (CFDP). CFDP was designed to provide file-based data and storage management, store-and-forward relay, and reliable data transfer over space links characterized by large propagation delay and intermittent availability. This paper will describe how MTO can use CFDP to relay operational data and bulk science data for surface missions such as the Mars Science Laboratory (MSL). Performance metrics for latency and storage requirement are derived from mathematical analysis as well as simulation of anticipated MTO-MSL mission scenarios
Oxidation property of silicon small particles (1991)

The oxidation rate of silicon small particles prepared by a gas-evaporation method and with diameters ranging from about 20 to 500 nm is investigated by high-resolution transmission electron microscopy. It is found that the oxidation rate of silicon small particles is less than the rate for wafers, and decreases with decreasing particle size. This phenomenon cannot be explained by the Deal–Grove model.
Supervisory control and data collection policies for a distribution center modeled as a discrete event system (2010)

A large scale discrete event model of a distribution center is presented where critical parameters identified were utilized to create a real-time scheduling control policy to improve throughput and redistribute work in process (WIP), reducing bottleneck process and overall WIP. In implementing the control policy, it was found that the data was queried multiple times at the same time stamp and continuously throughout the process during a time when the control policy specification would not be met. The amount of data collection, processing and storage can become expensive especially when implementing multiple control policies that are dependent on several critical parameters. There is a need for smart data collection, processing and storage policies for cost effectiveness and to manage existing power management and battery life issues that may occur with continuous data streaming with existing wireless devices and sensors. This paper presents both the real-time scheduling control policy and the data collection policy for a distribution center that must be considered simultaneously in order to realize the maximum benefits of a wireless real-time scheduling system.
The Rehabilitation Engineering Research Center on Aging (1994)

This article provides an overview of the major projects of the Rehabilitation Engineering Research Center on Aging (RERC-Aging). The RERC-Aging, housed at the University at Buffalo's Center for Assistive Technology, addresses research, device develop
Hybrid CMOS/memristor circuits (2010)

This is a brief review of recent work on the prospective hybrid CMOS/memristor circuits. Such hybrids combine the flexibility, reliability and high functionality of the CMOS subsystem with very high density of nanoscale thin film resistance switching devices operating on different physical principles. Simulation and initial experimental results demonstrate that performance of CMOS/memristor circuits for several important applications is well beyond scaling limits of conventional VLSI paradigm.
MEASUREMENT OF ENTRAINED ORGANIC DROPLET SIZES AND TOTAL CONCENTRATION FOR AQUEOUS STREAMS FROM THE CAUSTIC-SIDE SOLVENT EXTRACTION PROCESS (2007)

The Modular Caustic-Side Solvent Extraction Unit (MCU) and the Salt Waste Processing Facility will remove radioactive cesium from Savannah River Site supernate wastes using an organic solvent system. Both designs include decanters and coalescers to reduce carryover of organic solvent droplets. Savannah River National Laboratory personnel conducted experimental demonstrations using a series of four 2-cm centrifugal contactors. They also examined organic carryover during operation of a CINC (Costner Industries Nevada Corporation) V-5 contactor under prototypical conditions covering the range of expected MCU operation. This report details the findings from those studies and the implications on design for the MCU.
In Situ Sensitive Fluorescence Imaging of Neurons Cultured on a Plasmonic Dish Using Fluorescence Microscopy (2014)

A plasmonic dish was fabricated as a novel cell-culture dish for in situ sensitive imaging applications, in which the cover glass of a glass-bottomed dish was replaced by a grating substrate coated with a film of silver. Neuronal cells were successfully cultured over a period of more than 2 weeks in the plasmonic dish. The fluorescence images of their cells including dendrites were simply observed in situ using a conventional fluorescence microscope. The fluorescence from neuronal cells growing along the dish surface was enhanced using the surface plasmon resonance field. Under an epi-fluorescence microscope and employing a donut-type pinhole, the fluorescence intensity of the neuron dendrites was found to be enhanced efficiently by an order of magnitude compared with that using a conventional glass-bottomed dish. In a transmitted-light fluorescence microscope, the surface-selective fluorescence image of a fine dendrite growing along the dish surface was observed; therefore, the spatial resolution was improved compared with the epi-fluorescence image of the identical dendrite.
Reactivation of a supported gold catalyst for acetylene hydrochlorination (1988)

B. Nkosi, N. J. Coville and G. J. Hutchings, J. Chem. Soc., Chem. Commun., 1988, 71 DOI: 10.1039/C39880000071
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation (2019)

Abstract Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the abundance and types of PP2A complexes in cells, leading to transformation. Here we show that ST not only displaces common PP2A B subunits but also promotes A-C subunit interactions with alternative B subunits (B’’’, striatins) that are components of the Striatin-interacting phosphatase and kinase (STRIPAK) complex. We found that STRN4, a member of STRIPAK, is associated with ST and is required for ST-PP2A-induced cell transformation. ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation through the activation of the Hippo pathway effector YAP1. These observations identify an unanticipated role of MAP4K4 in transformation and show that the STRIPAK complex regulates PP2A specificity and activity.
Performance Evaluation of Linear Beamforming Receiver for Large CoMP Sparse Massive MIMO Channel Matrices (2017)

A massive multiple-input, multiple-output (mMIMO) downlink is considered with fixed wideband beams known as Grid of Beams (GoBs). The radio channel of a typical urban macro scenario will be shown to be sparse, and in combination with a linear maximum ratio combining beamforming method is used at the user equipment. Simulation results for urban macro cells show that reasonable spectral efficiencies are achieved with a moderate number of relevant channel components (RCCs) and accordingly limited feedback overhead for reporting of channel state information (CSI).
Reoperation and Mortality Rates Following Elective 1 to 2 Level Lumbar Fusion: A Large State Database Analysis (2021)

TLIF and combined anterior-posterior approaches for 1 to 2 level lumbar fusion are associated with the lowest rate of reoperation. Number of comorbidities and age are not predictive of reoperation. Primary etiologies leading to reoperation were degenerative disease and mechanical failure. Mortality rate is not increased from baseline following 1 to 2 level lumbar fusion.
Tunable continuous-wave terahertz generation/detection with compact 155 μm detuned dual-mode laser diode and InGaAs based photomixer (2011)

We demonstrate a tunable continuous-wave (CW) terahertz (THz) homodyne system with a novel detuned dual-mode laser diode (DML) and low-temperature-grown (LTG) InGaAs photomixers. The optical beat source with the detuned DML showed a beat frequency tuning range of 0.26 to over 1.07 THz. Log-spiral antenna integrated LTG InGaAs photomixers are used as THz wave generators and detectors. The CW THz radiation frequency was continuously tuned to over 1 THz. Our results clearly show the feasibility of a compact and fast scanning CW THz spectrometer consisting of a fiber-coupled detuned DML and photomixers operating in the 1.55-μm range.
Sweat facilitated losses of amino acids in Standardbred horses and the application of supplementation strategies to maintain condition during training (2015)

Little is known about the amino acid composition of horse sweat, but significant fluid losses can occur during exercise with the potential to facilitate substantial nutrient losses. Sweat and plasma amino acid compositions for Standardbred horses were assessed to determine losses during a standardised training regime. Two cohorts of horses 2013 (n=5) and 2014 (n=6) were assessed to determine baseline levels of plasma and sweat amino acids. An amino acid supplement designed to counter losses in sweat during exercise was provided after morning exercise daily for 5 weeks (2013, n=5; 2014, n=4). After the supplementation period, blood and sweat samples were collected to assess amino acid composition changes. From baseline assessments of sweat in both cohorts, it was found that serine, glutamic acid, histidine and phenylalanine were present at up to 9 times the corresponding plasma concentrations and aspartic acid at 0-2.2 μmol/l in plasma was measured at 154-262 μmol/l in sweat. In contrast, glutamine, asparagine, methionine and cystine were conserved in the plasma by having lower concentrations in the sweat. The predominant plasma amino acids were glycine, glutamine, alanine, valine, serine, lysine and leucine. As the sweat amino acid profile did not simply reflect plasma composition, it was proposed that mechanisms exist to generate high concentrations of certain amino acids in sweat whilst selectively preventing the loss of others. The estimated amino acid load in 16 l of circulating plasma was 3.8-4.3 g and the calculated loss via sweat during high intensity exercise was 1.6-3.0 g. Following supplementation, total plasma amino acid levels from both cohorts increased from initial levels of 2,293 and 2,044 µmol/l to post-supplementation levels of 2,674 and 2,663 µmol/l respectively ( P &lt;0.05). It was concluded that the strategy of providing free amino acids immediately after exercise resulted in raising resting plasma amino acid levels.
Chiral Amino Alcohol Modified Halomethylzinc Reagents (1992)

The enantioselective cyclopropanation of cinnamyl alcohol (3) to 2-phenylcyclopropanemethanol (4) using (1R,2S)-N-methylephedrine-modified halomethylzinc reagents is reported. Modest (up to 24% ee) enantioselectivites were observed, and a solvent induced reversal of selectivity was noted. These studies demonstrated the potential for chiral zinc species to differentiate olefin enantiofaces in the delivery of methylene to prochiral allylic alcohols.
Design and simulation tools for Embedded NOCs on FPGAs (2015)

We propose embedding hard NoCs on FPGAs to improve system-level communication as detailed in our previous studies [1-6]. This demo paper outlines the three main design and simulation tools that we have been using to experiment with Embedded NoCs on FPGAs.
Aortic-carotid artery pressure differences and cephalic perfusion pressure during cardiopulmonary resuscitation in humans (1991)

There is no clinically important aortic-carotid artery pressure difference during human CPR using the standard dose of epinephrine, even with prolonged CPR. Despite carotid artery patency and thoracic inlet venous valving, the cephalic perfusion pressure is low during CPR in humans.
Porcine Small Intestine Submucosa as a Flexor Tendon Graft (2004)

An attractive strategy for tendon tissue engineering is the use of natural extracellular matrices as scaffold materials. One matrix that has been shown to promote healing and regeneration of neotissue in various applications is porcine-derived small intestinal submucosa. It was the objective of this study to investigate small intestinal submucosa for intrasynovial flexor tendon grafting in a canine model. We hypothesized that at 6 weeks small intestinal submucosa grafts would undergo host cell infiltration, neovascularization, and replacement by host neotendon. We also hypothesized that small intestinal submucosa grafts would be incorporated by the host without extensive adhesions to surrounding tissues and therefore maintain normal digit function. An intrasynovial tendon autograft was used as a gold standard. At 6 weeks the intrasynovial tendon autografts remained viable, contained normal numbers of cells along their length, and had minimal peritendinous adhesions. Four of six autografts had normal function as determined by rotation of the distal interphalangeal joint. Also at 6 weeks, the small intestinal submucosa grafts had host cell infiltration, neovascularization, and wavy, oriented tissue. However, ubiquitous adhesions together with impaired function in all cases suggest that small intestinal submucosa grafts in the configuration used are not suitable as full-length intrasynovial grafts in this tendon and animal model.
Anticancer and immunostimulatory activity of the imipridone ONC201, a selective DRD2 antagonist, in advanced cancer patients. (2017)

2586 Background: ONC201 is an orally active, small molecule selective antagonist of the G protein-coupled receptor DRD2 that has established a new class of compounds referred to as imipridones. A first-in-human trial of ONC201 defined its recommended phase II dose (RP2D) as 625mg using once every three week administration that was very well tolerated at doses that yielded antitumor effects. ONC201 also showed stimulatory effects on immune cells in preclinical studies, including increased intratumoral NK cell infiltration in xenografts. Based on the exceptional safety profile of ONC201, weekly dosing has been evaluated. Methods: This open-label, 3+3 dose-escalation study used a starting dose of 375mg and escalated to 625mg using a weekly administration schedule. The primary endpoint was to determine the RP2D of ONC201 and secondary endpoints included PD, PK, toxicity, and anti-tumor efficacy. Based on signs of clinical activity and preclinical tumor type sensitivity studies of ONC201, the patient population was enriched for advanced glioblastoma, prostate cancer, and endometrial cancer. Six additional patients were treated at the weekly RP2D. Results: The RP2D for the weekly regimen was defined as 625 mg. Twelve evaluable patients were treated at this dose level and no drug-related AEs &gt; grade 1 occurred. Five patients had stable disease by RECIST criteria for 21-29 weeks. A metastatic prostate cancer who received 375mg ONC201 weekly had significantly diminished intensity in bone scans after 6 doses. PK was consistent with previous reports: Cmax consistently reaches therapeutic micromolar plasma concentrations, ~11 hour half-life, evidence of sustained and delayed activity, no systemic accumulation. In agreement with preclinical observations of ONC201-induced NK cell populations, a 2-10 fold increase in circulating activated NK cells was observed in 5 prostate cancer patients. Conclusions: ONC201 is well tolerated at an oral dose of 625mg weekly, exhibits sustained and late anti-cancer activity, and increases circulating NK cells. Observation in this study, and other clinical studies, warrant further evaluation of the immune oncology effects of ONC201. Clinical trial information: NCT02250781.
Error patterns in MLC NAND flash memory: Measurement, characterization, and analysis (2012)

As NAND flash memory manufacturers scale down to smaller process technology nodes and store more bits per cell, reliability and endurance of flash memory reduce. Wear-leveling and error correction coding can improve both reliability and endurance, but finding effective algorithms requires a strong understanding of flash memory error patterns. To enable such understanding, we have designed and implemented a framework for fast and accurate characterization of flash memory throughout its lifetime. This paper examines the complex flash errors that occur at 30-40nm flash technologies. We demonstrate distinct error patterns, such as cycle-dependency, location-dependency and value-dependency, for various types of flash operations. We analyze the discovered error patterns and explain why they exist from a circuit and device standpoint. Our hope is that the understanding developed from this characterization serves as a building block for new error tolerance algorithms for flash memory.
Structural Insights into Water-Based Spider Silk Protein–Nanoclay Composites with Excellent Gas and Water Vapor Barrier Properties (2016)

Nature reveals a great variety of inorganic-organic composite materials exhibiting good mechanical properties, high thermal and chemical stability, and good barrier properties. One class of natural bio-nanocomposites, e.g. found in mussel shells, comprises protein matrices with layered inorganic fillers. Inspired by such natural bio-nanocomposites, the cationic recombinant spider silk protein eADF4(κ16) was processed together with the synthetic layered silicate sodium hectorite in an all-aqueous setup. Drop-casting of this bio-nanocomposite resulted in a thermally and chemically stable film reflecting a one-dimensional crystal. Surprisingly, this bio-nanocomposite coating was, though produced in an all-aqueous process, completely water insoluble. Analyzing the structural details showed a low inner free volume due to the well-oriented self-assembly/alignment of the spider silk proteins on the nanoclay surface, yielding high oxygen and water vapor barrier properties. The here demonstrated properties in combination with good biocompatibility qualify this new bio-nanocomposite to be used in packaging applications.
Broadening the Scope of Binding Free Energy Calculations Using a Separated Topologies Approach (2023)

Binding free energy calculations predict the potency of compounds to protein binding sites in a physically rigorous manner and see broad application in prioritizing the synthesis of novel drug candidates. Relative binding free energy (RBFE) calculations have emerged as an industry-standard approach to achieve highly accurate rank-order predictions of the potency of related compounds; however, this approach requires that the ligands share a common scaffold and a common binding mode, restricting the methods' domain of applicability. This is a critical limitation since complex modifications to the ligands, especially core hopping, are very common in drug design. Absolute binding free energy (ABFE) calculations are an alternate method that can be used for ligands that are not congeneric. However, ABFE suffers from a known problem of long convergence times due to the need to sample additional degrees of freedom within each system, such as sampling rearrangements necessary to open and close the binding site. Here, we report on an alternative method for RBFE, called Separated Topologies (SepTop), which overcomes the issues in both of the aforementioned methods by enabling large scaffold changes between ligands with a convergence time comparable to traditional RBFE. Instead of only mutating atoms that vary between two ligands, this approach performs two absolute free energy calculations at the same time in opposite directions, one for each ligand. Defining the two ligands independently allows the comparison of the binding of diverse ligands without the artificial constraints of identical poses or a suitable atom-atom mapping. This approach also avoids the need to sample the unbound state of the protein, making it more efficient than absolute binding free energy calculations. Here, we introduce an implementation of SepTop. We developed a general and efficient protocol for running SepTop, and we demonstrated the method on four diverse, pharmaceutically relevant systems. We report the performance of the method, as well as our practical insights into the strengths, weaknesses, and challenges of applying this method in an industrial drug design setting. We find that the accuracy of the approach is sufficiently high to rank order ligands with an accuracy comparable to traditional RBFE calculations while maintaining the additional flexibility of SepTop.
Conformations of the 3,10-meso and (3R,10R)-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-dienenickel(II) complexes (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformations of the 3,10-meso and (3R,10R)-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-dienenickel(II) complexesTasuku. Ito and Daryle H. BuschCite this: Inorg. Chem. 1974, 13, 7, 1770–1772Publication Date (Print):July 1, 1974Publication History Published online1 May 2002Published inissue 1 July 1974https://pubs.acs.org/doi/10.1021/ic50137a049https://doi.org/10.1021/ic50137a049research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Torcetrapib Does Not Reduce Atherosclerosis Beyond Atorvastatin and Induces More Proinflammatory Lesions Than Atorvastatin (2008)

CETP inhibition by torcetrapib per se reduces atherosclerotic lesion size but does not enhance the antiatherogenic potential of atorvastatin. However, compared with atorvastatin, torcetrapib introduces lesions of a less stable phenotype.
Doping-Tunable Metamaterials in the Mid-Infrared. (2016)

Abstract not provided.
ON-State Reliability of Solid-Electrolyte Switch under Pulsed Alternating Current Stress for Programmable Logic Device (2011)

In this paper, we describes the ON-state reliability of a nonvolatile solid-electrolyte switch for a programmable logic device (PLD). The ON-state requirement for this application is different from that of a Cu via or an interconnect, since the pulsed-AC current is applied to the switch when the voltage changes in the interconnect. We experimentally demonstrate a recovering phenomenon in the migration under AC stress and propose an appropriate ON-state resistance of 800 Ω to satisfy the requirement for a current density criterion that goes beyond the 28-nm technology node (hp28). The ON-state duration of the crossbar switch under the pulsed-AC current of 1 GHz is estimated to be over 10 years at an ambient of 150 °C.