gebhart/patrepeval huggingface dataset:
Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactionsBruce E. Maryanoff, David F. McComsey, Harold R. Almond Jr., Martin S. Mutter, Guy W. Bemis, Robert R. Whittle, and R. A. OlofsonCite this: J. Org. Chem. 1986, 51, 8, 1341–1346Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/jo00358a034https://doi.org/10.1021/jo00358a034research-articleACS PublicationsRequest reuse permissionsArticle Views455Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Antibiotics Prescriptions in the Neonatal Intensive Care Unit: How to Overcome Everyday Challenges (2017)

Antimicrobial prescriptions in neonatal intensive care units (NICUs) represent a point of concern for the emergence of MDROs and for morbidity associated with prolonged antibiotic exposure (e.g., invasive candidiasis, necrotizing enterocolitis, and late-onset sepsis). Antimicrobial stewardship programs (ASPs) have shown to be a valuable tool for the prevention of resistance with the goals of optimizing clinical outcomes while decreasing unnecessary prescribing. The most frequent ASP strategies include the correct collection and interpretation of microbiological specimens, prescription of the narrowest-spectrum antibiotic appropriate for a particular case, and de-escalation or discontinuation of therapy in defined situations. A robust ASP requires everyday multidisciplinary collaboration between ID physicians, neonatologist, clinical pharmacists, clinical microbiologists, infection control professionals, hospital epidemiologists, and information services specialists. Education and clinical pathways (e.g., sepsis or surgical prophylaxis pathways) are an excellent starting point if followed by proactive interventions such as prospective audits and feedback and formulary restriction with prior antimicrobial authorization. The current review outlines the problems faced in NICU antimicrobial prescribing and presents various solutions from the literature.
Arabinogalactan (9kDa)-9-β-D-Arabinofuranosyladenine-5′-Monophosphate, A Novel Liver-Targeted Conjugate that Selectively Inhibits Hepatitis B virus Replication in Vitro (1997)

Arabinogalactan (9kDa)-9-β-D-arabinofuranosyladenine-5′-monophosphate [AG (9kDa)-araAMP] was 25-fold more active than the parent compound 9-β-D-arabinofuranosyladenine (araA) in decreasing the amount of hepatitis B virus (HBV) DNA intracellular replicative intermediates in HBV-transfected 2.2.15 cells. The putative active 5′-triphosphate metabolite, araATP, exhibited a 50% inhibitory concentration (IC50) of 5 μM toward woodchuck hepatitis virus DNA polymerase, consistent with the anti-HBV activity of these derivatives. AG (9kDa)-araAMP inhibited HepG2 cell proliferation by only 16% at a concentration as high as 822 μM (araA equivalents) and no effects were observed in the presence of 8.22 μM or 82.2 μM of the drug. Lactate production, mitochondrial DNA (mtDNA) content, and mitochondrial morphology were not affected by AG (9kDa)-araAMP at concentrations between 8.22 μM and 822 μM. In contrast, both araA and its in vivo metabolite, 9-β-D-arabinofuranosylhypoxanthine (araH), induced substantial dose-dependent effects on cell growth, lactate production and mtDNA steady-state levels at concentrations of 8.22 μM and 82.2 μM. Some loss of cristae within the mitochondria was also observed in cells incubated with araH. In summary, AG (9kDa)-araAMP exhibits a potent and selective anti-HBV activity and the lack of toxic effects on host cell mitochondrial functions supports its further development.
Evolution of Photonic Time Stretch: From Analog to Digital Conversion to Blood Screening (2011)

We show how the ability to slow down, amplify, and capture fast transient events can produce high-throughput real-time instruments ranging from digitizers to imaging flow cytometers for detection of rare diseased cells in blood.
Studies on the Constituents of Isodon trichocarpus KUDO. II. The Structures of Enmenin, Enmelol, and Ememodin (1970)

The structures of enmenin, enmelol, and ememodin, new diterpenoids isolated from Isodon trichocarpus KUDO were elucidated as I, II, and III, respectively.
Convenient Syntheses of Pyrimidino[4,5-b][1,5]benzodiazepinones and Pyrimidino[1,6-a]benzimidazolones (1986)

Pyrimidino[4,5-b][1,5]benzodiazepinones 4 and pyrimidino [1,6-a]benzimidazolones 5 were synthesized from 4-ethoxycarbonylamino-1H-1,5-benzodiazepine-3-carbonitrile (2) via ring transformation with some aliphatic primary amines. The reaction mechanisms for the formation of these compounds are proposed.
Novel application of Hemospray to achieve hemostasis in post-variceal banding esophageal ulcers that are actively bleeding (2014)

SCOPUS: no.j
Ultrafast reciprocal space investigation of cavity–waveguide coupling (2011)

Local information on the coupling mechanism between the photonic crystal nanocavity and the feeding waveguide is crucial to enable further improvements of the performance of these systems. Although several investigations on such a coupling have already been performed, information on the local dynamic properties remains hidden. Here, we present a reciprocal space investigation of the dynamics of light side-coupled to a photonic crystal nanocavity. We find that the coupling is promoted by Bloch harmonics having greater transverse momentum.
Canary in Twitter Mine: Collecting Phishing Reports from Experts and Non-experts (2023)

The rise in phishing attacks via e-mail and short message service (SMS) has not slowed down at all. The first thing we need to do to combat the ever-increasing number of phishing attacks is to collect and characterize more phishing cases that reach end users. Without understanding these characteristics, anti-phishing countermeasures cannot evolve. In this study, we propose an approach using Twitter as a new observation point to immediately collect and characterize phishing cases via e-mail and SMS that evade countermeasures and reach users. Specifically, we propose CrowdCanary, a system capable of structurally and accurately extracting phishing information (e.g., URLs and domains) from tweets about phishing by users who have actually discovered or encountered it. In our three months of live operation, CrowdCanary identified 35,432 phishing URLs out of 38,935 phishing reports, 31,960 (90.2%) of these phishing URLs were later detected by the anti-virus engine. We analyzed users who shared phishing threats by categorizing them into two groups: experts and non-experts. As a results, we discovered that CrowdCanary extracts non-expert report-specific information, like company brand name in tweets, phishing attack details from tweet images, and pre-redirect landing page information.
CONTROVERSIES IN CARDIOVASCULAR MEDICINE (2006)

the stem cell field has made enormous advances in movingtoward clinically applicable treatment options, and we nowstand at the dawn of a new therapeutic era. An abundance ofpreclinical data demonstrate safety, feasibility, and efficacy,justifying the current entry into clinical trials of stem celltherapy in humans.
Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes (1997)

These data show that VEGF and its receptors are localised to both vascular and avascular ERMs and suggest that VEGF, like PDGF-A, may be an autocrine and paracrine stimulator that may contribute to progression of vascular and avascular ERMs.
Incidence Lung Cancer after a Negative CT Screening in the National Lung Screening Trial: Deep Learning-Based Detection of Missed Lung Cancers (2020)

We aimed to analyse the CT examinations of the previous screening round (CT<sub>prev</sub>) in NLST participants with incidence lung cancer and evaluate the value of DL-CAD in detection of missed lung cancers. Thoracic radiologists reviewed CT<sub>prev</sub> in participants with incidence lung cancer, and a DL-CAD analysed CT<sub>prev</sub> according to NLST criteria and the lung CT screening reporting & data system (Lung-RADS) classification. We calculated patient-wise and lesion-wise sensitivities of the DL-CAD in detection of missed lung cancers. As per the NLST criteria, 88% (100/113) of CT<sub>prev</sub> were positive and 74 of them had missed lung cancers. The DL-CAD reported 98% (98/100) of the positive screens as positive and detected 95% (70/74) of the missed lung cancers. As per the Lung-RADS classification, 82% (93/113) of CT<sub>prev</sub> were positive and 60 of them had missed lung cancers. The DL-CAD reported 97% (90/93) of the positive screens as positive and detected 98% (59/60) of the missed lung cancers. The DL-CAD made false positive calls in 10.3% (27/263) of controls, with 0.16 false positive nodules per scan (41/263). In conclusion, the majority of CT<sub>prev</sub> in participants with incidence lung cancers had missed lung cancers, and the DL-CAD detected them with high sensitivity and a limited false positive rate.
Dynamische Selbstorganisation von Mikrokristallen über Nitroxidaustauschreaktionen (2010)

Perlenketten aus farbigen Zeolithkristallen: Die Kanaleingänge mit Farbstoff beladener roter und grüner Zeolith-L-Kristalle wurden ortsspezifisch entweder mit Alkoxyaminen oder mit Nitroxiden modifiziert. Eine milde radikalische Austauschreaktion alkoxyaminmodifizierter „grüner“ Zeolithe mit nitroxidmodifizierten „roten“ Kristallen führt zu hochgeordneten Ketten aus bis zu 15 kovalent verknüpften Kristallen mit streng alternierender Farbe.
Novel Fabrication Process to Realize Ultra-Thin (EOT = 0.7 nm) and Ultra-Low-Leakage SiON Gate Dielectrics (2006)

Abstract not Available.
An empirical evaluation of graspable user interfaces (1997)

This paper reports on the experimental evaluation of a Graspable User Interface that employs a "spacemultiplexing" input scheme in which each function to be controlled has a dedicated physical transducer, each occupying its own space. This input style contrasts the more traditional "time-multiplexing" input scheme which uses one device (such as the mouse) to control different functions at different points in time. A tracking experiment was conducted to compare a traditional GUI design with its time-multiplex input scheme versus a Graspable UI design having a space-multiplex input scheme. We found that the space-multiplex conditions out perform the time-multiplex conditions. In addition, we found that the use of specialized physical form factors for the input devices instead of generic form factors provide a performance advantage. We rugue that the specialized devices serve as both visual and tactile functional reminders of the associated tool assignment as well as facilitate manipulation due to the customized form factors.
Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (1988)

Genomic DNA clones containing the human and murine genes coding for the 50-kDa T11 (CD2) T-cell surface glycoprotein were characterized. The human T11 gene is approximately equal to 12 kilobases long and comprised of five exons. A leader exon (L) contains the 5'-untranslated region and most of the nucleotides defining the signal peptide [amino acids (aa) -24 to -5]. Two exons encode the extracellular segment; exon Ex1 is 321 base pairs (bp) long and codes for four residues of the leader peptide and aa 1-103 of the mature protein, and exon Ex2 is 231 bp long and encodes aa 104-180. Exon TM is 123 bp long and codes for the single transmembrane region of the molecule (aa 181-221). Exon C is a large 765-bp exon encoding virtually the entire cytoplasmic domain (aa 222-327) and the 3'-untranslated region. The murine T11 gene has a similar organization with exon-intron boundaries essentially identical to the human gene. Substantial conservation of nucleotide sequences between species in both 5'- and 3'-gene flanking regions equivalent to that among homologous exons suggests that murine and human genes may be regulated in a similar fashion. The probable relationship of the individual T11 exons to functional and structural protein domains is discussed.
Single-plane and multiplane quantitative phase imaging by self-reference on-axis holography with a phase-shifting method (2021)

A new quantitative phase imaging approach is proposed based on self-reference holography. Three on-axis interferograms with different values of the phase filter are superposed. The superposition yields a more accurate phase map of the wavefront emerging from the object, compared with standard off-axis interferometry. Reduced temporal noise levels in the measured phase map and efficient phase recovery process for optically thin and thick transmissive phase objects highlight the applicability of the suggested framework for various fields ranging from metrology to bio-imaging. Qualitative phase imaging is also done online without altering the optical configuration. Qualitative phase detections of multiple planes of interest are converted to quantitative phase maps of the multiplane scene by a rapid phase contrast-based phase retrieval algorithm, from a single camera exposure and with no moving parts in the system.
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability (2004)

In the present study, we demonstrated that a new strategy, which combined integrin-targeting the RGD peptide on the tip of PEG and modified the Ad using this material, could enhance gene expression in both CAR-positive and -negative cells. At the same time, this novel PEGylated Ad maintained strong protective activity against antibodies. This strategy could also be easily modified for developing other vectors using other targeting molecules.
Supplementary Data from Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma (2023)

Supplementary Data from Evaluation of Promoter Hypermethylation Detection in Body Fluids as a Screening/Diagnosis Tool for Head and Neck Squamous Cell Carcinoma
Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits. (2010)

Enterohemorrhagic Escherichia coli (EHEC) produce one or more types of Shiga toxins and are foodborne causes of bloody diarrhea. The prototype EHEC strain, Escherichia coli O157:H7, is responsible for both sporadic cases and serious outbreaks worldwide. Infection with E. coli that produce Shiga toxins may lead to diarrhea, hemorrhagic colitis, or (less frequently) hemolytic uremic syndrome, which can cause acute kidney failure. The exact mechanism by which EHEC evokes intestinal and renal disease has not yet been determined. The development of a readily reproducible animal oral-infection model with which to evaluate the full pathogenic potential of E. coli O157:H7 and assess the efficacy of therapeutics and vaccines remains a research priority. Dutch belted (DB) rabbits are reported to be susceptible to both natural and experimental EHEC-induced disease, and New Zealand white (NZW) rabbits are a model for the intestinal manifestations of EHEC infection. In the current study, we compared the pathology caused by E. coli O157:H7 infection in DB and NZW rabbits. Both breeds of rabbits developed clinical signs of disease and intestinal lesions after experimental infection. In addition, one of the infected DB rabbits developed renal lesions. Our findings provide evidence that both breeds are susceptible to E. coli O157:H7 infection and that both may be useful models for investigating EHEC infections of humans.
Production of Acetylene Black/silica Composite Particles by Adsorption of Polyethylenimine (2010)

ABSTRACT ：The acetylene black/silica composite particles were prepared by a simple and fast method using poly-ethylenimine (PEI) as a coupling agent. The composite particles were produced via the following two steps; adsorption of PEI on the surface of acetylene black particles and synthesis of silica by sol-gel process. The morphology of the compositeparticles was a core-shell, and a large number of micropores was created after silica was synthesized on the acetyleneblack surface.요 약：본 논문에서는 polyethyl eneimine (PEI)를 커플링제로 사용하여 간단한 공정을 통하여 아세틸렌 블랙/실리카복합체 입자를 제조하였다. 복합체 입자는 PEI를 아세틸렌 블랙 표면에 흡착시키고 졸-겔 합성공정을 통하여 실리 카를 아세틸렌 블랙 위에서 합성하는 두단계 공정을 통하여 제조되었다. 복합체 입자의 모폴로지 분석 결과 실리카가아세틸렌 블랙위에 존재하는 core-shell 구조를 확인하였으며, 표면에 상당한 미세기공이 존재함을 알 수 있었 다. Keywords ： acetylene black; silica; composite particles; polyethyleneimine; sol-gel reaction † Corresponding Author. E-mail: seshim@inha.ac.kr Ⅰ . Introduction Carbon black has been widely used as a filler in polymer industry because of its excellent properties such as heat, chem-ical and weathering resistance, lightweightness, electrocon-ductivity, and low thermal expansion.
Organo-f-element thermochemistry. Metal-ligand bond dissociation enthalpies in (pentamethylcyclopentadienyl)thorium hydrocarbyls, metallacycles, hydrides, and dialkylamides (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrgano-f-element thermochemistry. Metal-ligand bond dissociation enthalpies in (pentamethylcyclopentadienyl)thorium hydrocarbyls, metallacycles, hydrides, and dialkylamidesJoseph W. Bruno, Tobin J. Marks, and Lester R. MorssCite this: J. Am. Chem. Soc. 1983, 105, 23, 6824–6832Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ja00361a013https://doi.org/10.1021/ja00361a013research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Pulsed RF oscillations on a nonlinear capacitive transmission line (2013)

A nonlinear lumped element transmission line (NLETL) that consists of a nonlinear LC ladder network whose capacitors are nonlinear and inductors are linear can be used to produce oscillating pulses. This article describes the implementation of an oscillating pulse generator based on such high voltage nonlinear capacitive lines (NLCL) using commercial-off-the-shelf (COTS) components. Instead of using complex pulse forming networks or pulse forming lines, a storage capacitor and a fast semiconductor switch are used to provide an input pulse onto the cascading LC-elements of the NLCL with good approximation of a rectangular pulse-shape. The design of the NLCL is based on the NLETL circuit model that was developed earlier in-house. Experimental results are compared with simulations predicted by this NLETL model. The voltage modulation and the frequency content of the output pulses are analyzed. The conventional single NLCL produces a signal with a DC offset and a decoupling capacitor is needed at the end of the line to extract the AC component before injecting onto a load such as an antenna. A novel method of directly extracting the AC component without the use of a decoupling capacitor is proposed and investigated. Results of this direct AC extraction, which show the possibility of better performance, are discussed. The frequency tunability of this nonlinear line was also demonstrated.
Reliability Evaluation of the Design Space of the Granulation Process of Mefenamic Acid Tablets Using a Bootstrap Resampling Technique (2011)

The design space of the granulation process of mefenamic acid tablets, based on Box and Behnken design datasets, was described by a response surface method incorporating multivariate spline interpolation. The reliability of the optimal solutions and the acceptance ranges were evaluated by a bootstrap (BS) resampling technique. The distribution of the BS optimal solutions was almost symmetrical; however, several solutions, which were quite different from the original solution, were mixed. The reason for this problem was considered to be the mixing of the global and the local optima. Therefore, we applied self-organizing map (SOM) clustering for dividing data into several clusters and identified the cluster containing the global optima. The accuracy and reproducibility of the optimal solution in the cluster containing the optimal solution were quantitatively evaluated. In addition, the response surfaces modeled from all the BS datasets contained in the cluster were plotted into the same coordinates with the original response surface. The plots of BS optimal solutions were distributed around the original solution. Moreover, the average of all the BS response surfaces sufficiently corresponded with the original response surface. The conservative limits of the 95% confidence intervals of the acceptance ranges in three response variables could be calculated using the standard deviations of the BS response surfaces. Consequently, it was considered that a novel evaluation method based on BS resampling and SOM could be used for quantitatively evaluating the precision of the nonlinear response surface model.
Steering from the Centre in France in the 2000's. When Reorganizations meet Politicization (2011)

Over the past thirty years, there is no doubt that the French state has been affected by many major transformations, potentially sufficiently significant to have altered the forms of governing and specific modes of steering from the centre. Starting in the 1980s, major privatization and decentralization programs have been implemented and have generated dynamics ‘decentring’ government activity. As in other Western countries, new ideas drawn from New Public Management (performance management, contracts, public-private partnership, etc.) have been subjected to specific importation and interpretation processes, giving rise to administrative reform programs characterized by their gradual development (Bezes 2009)