gebhart/patrepeval huggingface dataset:
Advances in Culture and Manipulation of Human Pluripotent Stem Cells (2013)

Recent advances in the understanding of pluripotent stem cell biology and emerging technologies to reprogram somatic cells to a stem cell–like state are helping bring stem cell therapies for a range of human disorders closer to clinical reality. Human pluripotent stem cells (hPSCs) have become a promising resource for regenerative medicine and research into early development because these cells are able to self-renew indefinitely and are capable of differentiation into specialized cell types of all 3 germ layers and trophoectoderm. Human PSCs include embryonic stem cells (hESCs) derived from the inner cell mass of blastocyst-stage embryos and induced pluripotent stem cells (hiPSCs) generated via the reprogramming of somatic cells by the overexpression of key transcription factors. The application of hiPSCs and the finding that somatic cells can be directly reprogrammed into different cell types will likely have a significant impact on regenerative medicine. However, a major limitation for successful therapeutic application of hPSCs and their derivatives is the potential xenogeneic contamination and instability of current culture conditions. This review summarizes recent advances in hPSC culture and methods to induce controlled lineage differentiation through regulation of cell-signaling pathways and manipulation of gene expression as well as new trends in direct reprogramming of somatic cells.
Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans (2021)

Overall, our data demonstrate that insulin pulse characteristics, considered independently of other factors, do not correlate with measures of hepatic and peripheral insulin sensitivity in nondiabetic humans.
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells (2015)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Origins and Manifestations of Speckle (2020)

In the early 1960s, when continuous-wave lasers first became commercially available, researchers working with these instruments noticed what at the time was regarded as a strange phenomenon. When laser light was reflected from a surface such as paper, or the wall of the laboratory, a high-contrast, fine-scale granular pattern would be seen by an observer looking at the scattering spot. In addition, measurement of the intensity reflected from such a spot showed that such fine-scale fluctuations of the intensity exist in space, even though the illumination of the spot was relatively uniform. This type of granularity became known as “speckle.”
Simultaneous quantification of 30 different bioactive compounds including polyphenols in spent coffee ground and coffee silverskin by HPLC-MS/MS triple quadrupole (2019)

Coffee is one of the most consumed beverages worldwide and according to the latest statistics the global consumption is more than 150 million of 60 kg coffee bags per year. As a consequence, large amount of coffee residues need to be disposed of [1]. Although many studies related to coffee and health have been carried out in green, ground and espresso coffee, two components of the coffee processing chain have been less investigated, i.e. coffee silverskin (CS) and spent coffee ground (SCG), the two main by-products presenting a huge potential to be valorized [2]. It is well known that coffee is a rich source of polyphenols, phytochemicals associated with many biological activities, and they are partially extracted from the beans during brewing; so, the resulting spent coffee is still a rich source of polyphenolic compounds. Similarly, silverskin is also considered to be a potential source of polyphenolic compounds because this tegument is in direct contact with the beans; therefore, it keeps part of the polyphenolic compounds constituents present in coffee beans [3].&#13;\nOn these bases, general aim of this project was to deepen the knowledge on CS and SCG, in the future perspective of their re-use as nutraceuticals by a) developing an efficient and low-cost method to extract different bioactive compounds including polyphenols from these by-products b) quantifying these bioactive compounds (chlorogenic acids, caffeine and other important coffee polyphenols such as flavonoids and phenolic acids) from different CS and SCG extracts by developing new HPLC-MS/MS analytical method.&#13;\nSCG and CS samples were extracted by using different solvents and extraction procedures (i.e. magnetic stirrer, ultrasound extraction). From an analytical point of view, UHPLC–MS/MS studies were performed using an Agilent 1290 Infinity series and a Triple Quadrupole 6420 from Agilent Technology equipped with an ESI source operating in negative ionization mode. The separation was achieved using a Kinetex C18 analytical column (50 mm × 2.10 mm i.d., 2.6 μm) using a binary gradient of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). The method was sensitive (LOQs for all compounds were in the range 1-100 μg kg-1), linear (R2 for all analytes was higher than 0.9907), accurate and robust. The best extraction procedure in term of amount of bioactive compounds extracted was ultrasound extraction with a mixture of ethanol:water 70:30 v/v; in this case, the highest amount of total bioactive compounds concentration was found.&#13;\nIn the future, the most promising extracts in terms of bioactive compounds will be tested to evaluate theirs prebiotic and antimicrobial activity, in the perspective of their re-use as nutraceuticals.
Vision-based estimation of bolt-hole location using Circular Hough Transform (2009)

In order to use a robot in the construction automation filed, we proposed the concept of Bolting Robot and a visual servo control scheme to track a bolting tool to a bolt hole in the structural steel frame. For estimating a location of a bolt hole, Circular Hough Transform (CHT) was used to extract circles. Generally, CHT is computationally complex due to a power of the dimensionality of a circle. A distance from a camera to a steel frame can be measured by using laser range-finder installed. The radius of a bolt hole can be calculated with the distance to a steel frame. Since the radius is known, the processing of CHT can be reduced to 2D. In addition, it contains image pre-processing to make an image of bolt holes to be clear. Pre-processing has 4 steps which consist of compensating lens distortion, noise filtering, histogram equalization, and edge detection.
Analysis of two strains of Friend murine leukemia viruses differing in ability to induce early splenomegaly: lack of relationship with generation of recombinant mink cell focus-forming viruses (1986)

Friend murine leukemia helper viruses (F-MuLV) 57 and B3 were indistinguishable by genomic structural analyses with RNase T1-resistant oligonucleotide fingerprinting and by antigenic reactivity with a panel of 31 monoclonal antibodies directed against murine leukemia viruses. Nevertheless, F-MuLV 57 and B3 had strikingly different virulences. Approximately 2 months after inoculation, IRW and NFS/N mice inoculated as newborns with F-MuLV 57 had gross splenomegaly caused by erythroid proliferation. In contrast, an equivalent dose of F-MuLV B3 induced spleen or lymph node enlargement 4 to 13 months after inoculation. Although most cases of spleen enlargement in F-MuLV B3-inoculated mice were due to erythroid proliferation, lymphoid or myeloid proliferation was also frequently observed. The replication of both F-MuLV 57 and B3 was equally efficient, and both viruses generated recombinant dual-tropic mink cell focus-forming (MCF) viruses with the same kinetics and efficiency. Moreover, MCF viruses induced by F-MuLV 57 and B3 had the same antigenic patterns. Therefore, the ability of F-MuLV to induce early splenomegaly did not correlate with the generation of recombinant MCF viruses.
Percutaneous Management of Calculi Within Horseshoe Kidneys (2003)

Percutaneous treatment of patients with renal calculi in a horseshoe kidney is technically challenging, usually requiring upper pole access and flexible nephroscopy due to the altered anatomical relationships of the fused renal units. The success rate based on stone-free results and a relatively low incidence of major complications suggest that this minimally invasive management option is an effective means of stone management in this complex patient population.
Growth and conductivity control of high quality AlGaN and its application to high-performance ultraviolet laser diodes (2009)

A microstructure in AlGaN with a whole compositional range on an AlN/sapphire template is systematically investigated. At the interface between AlGaN and AlN, misfit dislocation density increases with Ga composition in AlGaN. However, most misfit dislocations bend owing to the compressive stress and form loops, by which threading dislocation density is markedly reduced if the thickness exceeds several microns. The effective acceptor energy of Mg in Al<sub>0.5</sub>Ga<sub>0.5</sub>N is found to depend on Mg concentration with a negative one-third power. A SiO<sub>2</sub>/AlN dielectric multilayer mirror is very effective for controlling the reflectivity of the Fabry-Perot resonator mirrors at the cleaved edge of the ultraviolet (UV) laser diodes (LDs). A UV LD with an emission wavelength of 358 nm shows a threshold current density as low as 3.9 KA/cm<sup>2</sup> at room temperature.
Plasma Gelsolin and Its Association with Mortality and Hospitalization in Chronic Hemodialysis Patients (2017)

Even though pGSN was inversely correlated with age, CRP and IL-6, suggesting that inflammation may influence pGSN, lower pGSN levels were not associated with hospitalization, all-cause and cardio-vascular mortality in this patient population.
Resource and Information Sharing for the Installation Process of the Offshore Wind Energy (2017)

The costs of the installation phase of the production system offshore wind energy plant have a considerable influence on the electricity production costs. For this reason, there are efforts undertaken to reduce the installation costs. The resources (e.g. installation vessels) and information (e.g. weather forecasts) play a vital role in the logistics installation network. This paper investigates the potential of a shared use of resources and the sharing of different information in the installation phase of the offshore wind energy by means of an event discrete, agent-based simulation. This is motivated by the large number of wind parks still to be installed in the future. To this end, simultaneously installed wind farm projects are examined and the effects of exchange of different information are investigated. The impact of weather restrictions on the processes of loading, transport and installation is taken into consideration. By means of the resource and information sharing approaches, significant savings potential was identified for the offshore wind energy installation.
Recent trends in high power microwave source research: Multispectral and phase coherent solutions (2012)

The development of high power microwave (HPM) sources that can be used in intentional electromagnetic interference (IEMI) applications has matured over the past two decades. The development of fully electromagnetic particle-in-cell codes has revolutionized the source design process. Virtual prototyping has replaced experimental tinkering to streamline the design of sources with new capabilities. This paper reviews recent advances in HPM source capabilities, particularly those with multispectral capabilities. Additionally, the ganging of several sources in a phase coherent manner to achieve a higher power output will also be reviewed. Not intended as a comprehensive review, this paper will highlight recent examples of advances that are representative of both novel capabilities.
Fabrication and applications of Draw Tower Gratings (2016)

The paper will highlight some motivation, fabrication and application aspects of FBG created during the drawing process of an optical fiber (DTG). Motivation aspects of this drawing tower FBG inscription technology are first of all the extremely high number of FBG in one optical fiber and the very high productivity resulting from this. A second very important aspect is the very good mechanical strength of the FBGs coming from the continuous process including polymer coating applying at the fiber surface. These advantages are the main reasons why such DTGs are very attractive especially for sensor applications of FBG but also for some telecom applications and a special type of wavelength switchable laser.
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 (2021)

Subcutaneous REGEN-COV prevented symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection in previously uninfected household contacts of infected persons. Among the participants who became infected, REGEN-COV reduced the duration of symptomatic disease and the duration of a high viral load. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials.gov number, NCT04452318.).
A Solution Processable Dithioalkyl Dithienothiophene (DSDTT) Based Small Molecule and Its Blends for High Performance Organic Field Effect Transistors (2020)

The 3,5-dithiooctyl dithienothiophene based small molecular semiconductor <b>DDTT-DSDTT</b> (<b>1</b>), end functionalized with fused dithienothiophene (<b>DTT</b>) units, was synthesized and characterized for organic field effect transistors (OFET). The thermal, optical, electrochemical, and computed electronic structural properties of <b>1</b> were investigated and contrasted. The single crystal structure of <b>1</b> reveals the presence of intramolecular locks between S(alkyl)···S(thiophene), with a very short S-S distance of 3.10 Å, and a planar core. When measured in an OFET device compound <b>1</b> exhibits a hole mobility of 3.19 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, when the semiconductor layer is processed by a solution-shearing deposition method and using environmentally acceptable anisole as the solvent. This is the highest value reported to date for an all-thiophene based molecular semiconductor. In addition, solution-processed small molecule/insulating polymer (<b>1</b>/PαMS) blend films and devices were investigated. Morphological analysis reveals a nanoscopic vertical phase separation with the PαMS layer preferentially contacting the dielectric and <b>1</b> located on top of the stack. The OFET based on the blend comprising 50% weight of <b>1</b> exhibits a hole mobility of 2.44 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> and a very smaller threshold voltage shift under gate bias stress.
Design of a miniaturized UHF-band Zigbee antenna applicable to the M2M/IoT communication (2014)

In this paper, a miniature UHF-band Zigbee antenna is proposed. Considering a lighter weight and smaller footprint of the Zigbee platform attached to a walking person, the antenna is meandered on the top and partially short circuited on the bottom, and optimized with non-uniform widths and lengths of the radiating element, and capillary paths. Due to these contributing factors, the physical area is reduced by roughly 50% from the simple monopole antenna. Besides, the bandwidth of 20 MHz is obtained for the resonance frequency of 915 MHz, working appropriately for the UHF-band Zigbee application such as M2M and IoT. The full-wave simulation with the measurement verifies the proposed design.
(IBA Early Career Award) Challenges and Opportunities for Interphased Ca Metal Anode Batteries (2019)

Various metals have been used as battery anodes in electrochemical cells ever since the birth of the batteries with Volta’s pile and in the first commercialized primary (Zn/MnO 2 , Leclanché 1866) and secondary (Pb/acid, Planté 1859) batteries. Li-MoS 2 cells, employing Li metal anodes, with specific energies two to three times higher than both Ni/Cd and Pb/acid cells, were withdrawn from the market due to safety issues related to dendrites growth. Instead, electrodeposition of Mg and Ca appears to be less prone to dendrite formation.[1,2] Pioneering work by Aurbach et al. in the early 1990’s showed a surface-film controlled electrochemical behavior of Ca and Mg metal anodes in electrolytes with conventional organic solvents.[3,4] The lack of metal plating was attributed to the poor divalent cation migration through the passivation layer. Nevertheless, recent demonstration of Ca and Mg plating and stripping in the presence of a passivation layer or an artificial interphase [2,5,6] has paved the way for assessment of new electrolyte formulations with high resilience towards oxidation. However, several challenges remain to be tackled for the development of Ca based batteries.[7] Among these, the need for reliable electrochemical test protocols, mass transport limitations and high desolvation energies (due to strong cation-solvent and cation–anion interactions) are implied.[8] Here, the reliability of electrochemical set-ups involving multivalent chemistries is discussed, and a systematic investigation on the impact of the electrolyte formulation on the cation solvation structure and transport is presented. Finally, a systematic characterization of the SEI formed on the Ca metal anode in various electrolyte formulations using complementary techniques allowed for the identification of the most suitable SEI compounds in terms of divalent cation mobility. Reference s : [1] M. Matsui, J. Power Sources, 196 (2011) 7048. [2]. A. Ponrouch, C. Frontera, F. Bardé, M.R. Palacín, Nat. Mater., 15 (2016) 169. [3] D. Aurbach, R. Skaletsky, Y. Gofer, J. Electrochem. Soc.138 (1991) 3536. [4] Z. Lu, A. Schechter, M. Moshkovich, D. Aurbach, J. Electroanal. Chem. 466 (1999) 203. [5] D. Wang, X. Gao, Y. Chen, L. Jin, C. Kuss, P. G. Bruce, Nat. Mater. 17 (2018) 16. [6] S.-B. Son, T. Gao, S. P. Harvey, K. X. Steirer, A. Stokes, A. Norman, C. Wang, A. Cresce, K. Xu, C. Ban, Nat. Chem. 10 (2018) 532. [7] A. Ponrouch, M.R. Palacín, Current Opinion in Electrochemistry 2018,doi.org/10.1016/j.coelec.2018.02.001. [8] D. S. Tchitchekova, D. Monti, P. Johansson, F. Bardé, A. Randon-Vitanova, M. R. Palacı́n, A. Ponrouch, J. Electrochem. Soc., 164 (2017) A1384. Figure 1: Scheme of a Ca metal anode-based battery with the main problems/ requirements outlined.[7] Figure 1
Impact of microcystin containing diets on physiological performance of Nile tilapia (Oreochromis niloticus) concerning detoxification (2010)

Nile tilapia (Oreochromis niloticus) were fed by diets supplemented with cyanobacteria containing in part the cyanotoxin microcystin-LR (MC-LR) to determine the potential impacts on detoxification. Four different diets were prepared based on a commercial diet: (1) control, (2) MC-5% (containing 5% dried Microcystis sp. biomass with 4.92 μg MC-LR g(-1) diet), (3) MC-20% (containing 20% dried Microcystis sp. biomass with 19.54 μg MC-LR g(-1) diet), and (4) Arthr-20% (containing 20% dried Arthrospira sp. biomass without MC-LR). Blood and liver samples were taken after one, 7, and 28 days and protein has been determined in plasma and liver. In the liver, impacts on detoxification were measured by glutathione-S-transferase (GST) activities and gene expression of multi drug resistance protein (MDRP). Plasma protein did not change between all four diets at any sampling time whereas liver protein was significantly elevated already after one day in Arthr-20% and after 28 days in both, MC-20% and Arthr-20%. Biochemical measurements of GST activities revealed no significant impact at any sampling time. In order to characterize the potential effect of MC-LR on MDRP, RT-qPCR method was established. However, as for GST activities no significant changes in MDRP gene expression have been observed. Thus, in summary, oral exposure of MC-LR containing cyanobacteria to Nile tilapia via feed ingestion did not impact significantly detoxification in liver concerning GST activities and MDRP expression despite biochemical composition concerning liver protein was significantly elevated by the diets containing 20% cyanobacteria biomass, regardless whether they contained MC-LR or not.
Power Consumption of Customized Numerical Representations for Audio Signal Processing (2002)

Presentation on the power consumption of customized numerical representations for audio signal processing.
Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer (2020)

Baicalein is a Chinese herbal compound extracted from <i>Scutellaria baicalensis</i> that has anti-tumor properties. The aim of this study was to elucidate the mechanisms of action of baicalein against human colorectal cancer cell lines and to assess whether the anti-proliferative effects of baicalein may be amplified with autophagy inhibition. Human colon cancer cell lines (HT-29, HCT-116, SW480, and SW620) were treated with baicalein alone and in combination with the autophagy inhibitor chloroquine (CQ). Baicalein reduced cell viability in all four colon cancer lines in a dose-dependent fashion. Combination treatment of baicalein and the autophagy inhibitor CQ significantly decreased cell viability compared with baicalein alone in HT-29 and HCT-116 cell lines. Western blot analysis of the HCT-116 cell line treated with both baicalein and CQ demonstrated increased expression of LC3-II, a component of autophagy. The combination of baicalein with CQ culminated in activation of caspase-3-mediated apoptosis. These findings demonstrate that inhibition of autophagy enhanced apoptotic cell death induced by baicalein treatment in colon cancer cell lines. Future work will assess other targetable apoptotic pathways activated by baicalein and autophagy inhibition.
Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells (2013)

The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors. Tumors contain features of acinar-type adenocarcinoma with elevated eIF4E-driven protein translation and squamous cell carcinoma marked by activated beta-catenin. Lentiviral integration site analysis revealed that alternative histological phenotypes can be clonally derived from a common cell of origin. In advanced disease, adenocarcinoma can be propagated by self-renewing tumor cells with an androgen receptor-low immature luminal phenotype in the absence of basal-like cells. These data indicate that advanced prostate adenocarcinoma initiated in basal cells can be maintained by luminal-like tumor-propagating cells. Determining the cells that maintain human prostate adenocarcinoma and the signaling pathways characterizing these tumor-propagating cells is critical for developing effective therapeutic strategies against this population.