gebhart/patrepeval huggingface dataset:
Single agent ONC201 in adult recurrent H3 K27M-mutant glioma. (2019)

3005 Background: H3 K27M-mutant glioma is associated with a poor prognosis and there is no effective therapy following radiation. We report the clinical experience with single agent ONC201, the first small molecule DRD2 antagonist in oncology, in adults with recurrent H3 K27M-mutant glioma. Methods: Twenty-nine adult patients with recurrent H3 K27M-mutant glioma have been treated with single agent ONC201 as of January 20, 2019: 19 patients on NCT03295396; 8 patients on NCT02525692; 2 patients on compassionate use protocols under the Sponsor’s IND. Median age was 57 years old (range: 17-74), median prior lines of therapy was 2 (range: 1-4) and all patients received prior radiation (median 8.5 months from radiation completion to ONC201 initiation). ONC201 was orally administered at 625 mg weekly, except for one patient dosed once every 3 weeks. Results: As of February 5, 2019, 13 of 29 patients remain on-trial within median follow up of 6.5 months (range: 0.6-33.6), 8 patients are alive but off-trial with median follow up of 2.4 months (range: 0.2-9), and 8 patients have expired. Nine of 29 patients (31%) remain progression-free on ONC201 with a median follow up of 6.5 months (range 0.6-33.6). No dose-limiting toxicities or treatment discontinuations due to toxicity occurred. Three patients have experienced durable partial responses by RANO (4.3-28.5 months). In addition, one patient experienced complete regression that continues for &gt; 14 months of all &lt; 1 cm tumor lesions that are not measurable by RANO. Furthermore, 10 patients had a best response of stable disease by RANO, 12 patients experienced progressive disease, and 3 patients are not yet evaluable. Among the patients with a best response of stable disease by RANO, one patient had &gt; 50% tumor regression in the basal ganglia that did not qualify as a partial response by RANO due to a new lesion on a confirmatory scan. Another patient with stable disease by RANO has had 37% tumor regression so far in the brainstem and remains on-treatment for 6 months. All tumor regressions remain durable to date and some were associated with improvements in disease-associated neurological symptoms. Conclusions: Single agent ONC201 is well tolerated and clinically active in adult recurrent H3 K27M-mutant glioma patients. Clinical trial information: NCT03295396; NCT02525692.
Performance of a DC/AC/DC VSC System to Interconnect HVDC Systems (2012)

Interconnection of High Voltage Direct Current (HVDC) links into networks is key to a future HVDC grid spanning large regions. Various factors including the evolution of cable technology will lead to a variety of DC voltages and a need to provide a DC/DC step up/down at high power ratings (beyond 500 MW). This paper analyses a High Voltage (HV) DC/DC converter utilising an intermediate AC link between two modular multi-level converters (MMC) based on the Alternate Arm Converter (AAC) topology. System operation is demonstrated using a detailed Simulink simulation. Power loss estimates derived from the simulation are used to illustrate the dependence of efficiency on design choices and operating point. Furthermore, the system is shown to block a DC-side fault and prevent its affect propagation through the system. (6 pages)
Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study (2021)

The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.
Capacitor switched gate-turnoff thyristor (1993)

Gate-turnoff performance of the gateturnoff thyristor (GTO) through the transient current of a capacitor is studied. Experimental results on such a capacitor-switched GTO (CSG) show that a large negative transient current is obtained resulting from the discharge of a capacitor attached to the gate of the GTO. Very high turnoff current in the CSG can be achieved. A simple MOS-controlled gate-driving circuit is proposed which provides full voltage control of the GTO. Comparison between the CSG and the GTO-cascode switch is also carried out.
Simulated Clinical Environments and Virtual System-of-Systems Engineering for Health Care (2010)

Our global security environment is increasingly affected by biological systems. From the threats of pandemics and bioterrorism to the exploding cost of health care, developing the means to effectively and affordably solve problems related to biological systems is critical to our quality of life. When considering health care costs, the numbers are staggering. Approximately half of the $2.4 trillion spent annually on US health care can be categorized as preventable costs, and $300 billion of this is attributable to medical mistakes and the defensive medicine they engender. Just as the use of flight simulators and system integration concepts revolutionized the aircraft industry decades earlier, similar concepts can be applied to improve the effectiveness and efficiency of the health care industry today. Our approach is intended to leverage advanced modeling and simulation techniques to accurately represent complex clinical environments. By creating hierarchical simulated models of these systems and then validating these models against their real-world equivalents, we are able to develop a virtual system-of-systems integration laboratory for clinical environments. As with comparable tools in aviation, our goal is for simulationbased tools for health care to make analysis and training fast, safe, measureable, and reproducible. This will be a significant step forward in health care, which has trailed other fields in the adoption of software simulations, due to technological limitations and behavioral barriers. We believe that a holistic approach such as this will pave the way for the next generation of decision support aids, medical devices, and training systems for applications across the health care spectrum. In this paper, we outline our approach with detailed examples of potential savings for a number of complex clinical scenarios.
Supplemental Figure 7 from Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer (2023)

&lt;p&gt;Palbociclib's stromal impact and cancer outcomes&lt;/p&gt;
Effect of Channel Layer Thickness on Characteristics and Stability of Amorphous Hafnium–Indium–Zinc Oxide Thin Film Transistors (2011)

We investigated the channel layer thickness dependence of the characteristics and stability in amorphous hafnium indium zinc-oxide (HIZO) thin film transistors (TFTs). HIZO TFTs were prepared with various channel thicknesses from 400 to 700 Å. In HIZO TFTs, carrier concentration is considerably high, which leads to channel layer thickness dependence. The threshold voltages of TFTs negatively shifted as the channel thickness increased. The threshold voltage shift at a high temperature is more severe in TFTs with thicker channel layers. The channel thickness dependence of the bias stability of HIZO TFTs is closely related to the back interface, rather than the bulk state.
ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids (2001)

Synthesis of protoporphyrin IX (PpIX) in intact murine mammary cancer cell spheroids is reported from optical sections obtained using a laser scanning confocal fluorescence microscope. EMT6 spheroids 275-350 microm in diameter were incubated in 0.1-15 mM aminolevulinic acid (ALA) or 0.001-2 mM ALA-hexylester (h-ALA) to test the ability of both pro-drugs to diffuse into the spheroids and induce PpIX production. Spheroids incubated with ALA show significant fluorescence nonuniformity for all concentrations, with the outermost cells exhibiting greater porphyrin fluorescence. Comparable levels of fluorescence throughout the optical section are achieved with approximately 100-fold lower h-ALA concentrations, indicating that the interior cells maintain esterase activity and porphyrin synthesis and that h-ALA diffuses efficiently to the spheroid interior. Fluorescence gradients are less pronounced with h-ALA incubation, in part because of apparent saturation of esterase activity in the spheroid perimeter. Proliferating (Ki67 positive) and quiescent cell populations exhibit remarkably different h-ALA concentration dependencies. The incubation concentration resulting in maximum fluorescence with ALA is 10 mM, while the optimal concentration for h-ALA is 200-fold lower at 0.05 mM. Exceeding these optimal concentrations for both pro-drugs leads to an overall loss of fluorescence.
Chains Anchored onto Convex Spherical Surfaces. Modification of the Daoud and Cotton Model (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChains Anchored onto Convex Spherical Surfaces. Modification of the Daoud and Cotton ModelJ. M. R. d'Oliveira, J. M. G. Martinho, Renliang Xu, and Mitchell A. WinnikCite this: Macromolecules 1995, 28, 13, 4750–4752Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ma00117a060https://doi.org/10.1021/ma00117a060research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient First Stokes Generation Using A Raman Oscillator (1989)

Efficient generation of first Stokes Raman radiation can be achieved with an External Raman Oscillator (ERAMOS). In our experiments a CH4-Raman oscillator was pumped by a Nd:YAP laser. By incorporating this Raman Resonator (IRAMOS) in the pump resonator a further increase in efficiency and a lowering of the threshold can be obtained. The experimental results were discussed and compared with our theoretical calculations.
Effect of switch capacitance on zero-voltage switching of resonant converters (2003)

The authors present an analysis of the series-parallel resonant power converter (SPRC) that includes the capacitance of the switches. New DC characteristics are obtained, and the regions where the converter operates with zero voltage switching are determined as a function of the switch capacitance. The analysis is also valid for series and parallel resonant converters. The analysis is verified experimentally on a 50 W, 1 MHz SPRC converter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies (2020)

Antibody engineering technologies face increasing demands for speed, reliability and scale. We developed CeVICA, a cell-free antibody engineering platform that integrates a novel generation method and design for camelid heavy-chain antibody VHH domain-based synthetic libraries, optimized <i>in vitro</i> selection based on ribosome display and a computational pipeline for binder prediction based on CDR-directed clustering. We applied CeVICA to engineer antibodies against the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike proteins and identified >800 predicted binder families. Among 14 experimentally-tested binders, 6 showed inhibition of pseudotyped virus infection. Antibody affinity maturation further increased binding affinity and potency of inhibition. Additionally, the unique capability of CeVICA for efficient and comprehensive binder prediction allowed retrospective validation of the fitness of our synthetic VHH library design and revealed direction for future refinement. CeVICA offers an integrated solution to rapid generation of divergent synthetic antibodies with tunable affinities <i>in vitro</i> and may serve as the basis for automated and highly parallel antibody generation.
An Energy Efficient Manipulator Design Approach: Application to a Leg in Swing Phase (2006)

The importance of energy efficiency of a robotic manipulator is clearly evident when the manipulator has to use on-board power. With miniature machines, this issue is even more important since the size and the weight guides the performance of a design. In this paper, a design methodology is proposed which may allow a robot to follow desired trajectories approximately without actuator inputs. Actuator inputs are used to further modify the trajectories. The design philosophy has the following key elements: (i) the inertia matrix of the device is suitably altered using mass distribution; (ii) compliant elements are introduced to take away the gravity terms; and (iii) additional springs are used to create certain periodic gait motion. This design philosophy is applied on a two dof leg executing a swing motion. It is found that the passive motion of the designed leg is close to the desired trajectories but is not exact. Actuators are added to get the desired response fully. Power input for two legs with and without this design philosophy, are then compared.
Préserver les œuvres musicales créées avec dispositif numérique par l'étude du processus compositionnel (2012)

De tradition pluriseculaire, et reposant sur un substrat stable tripartite compose de la partition, de l’organologie et de la lutherie, la preservation et la transmission des œuvres musicales sont menacees par les systemes electroniques et numeriques. Ces derniers ont transforme les pratiques de composition et entrainent une obsolescence technologique de plus en plus rapide. Devant la necessite de mettre a jour les œuvres afin de les rejouer, il nous parait fondamental d’etudier les processus de production et d’en extraire les informations pertinentes necessaires pour ressaisir certaines intentions du compositeur. Notre approche se fonde sur la creation d’un langage de representation des pratiques de composition, utilise dans un environnement permettant de capter une production et d’y naviguer.
Changes in Pupil Dynamics at High Altitude—An Observational Study Using a Handheld Pupillometer (2008)

Gross pupil dynamics are used as an indirect measure of brain function. Changes in hypoxia and intracranial pressure are thought to alter pupil responses to light. This study assessed a portable handheld pupil measuring device (pupillometer) in the field investigating the changes in pupil size, speed of reaction, and rate of constriction/dilatation with hypoxia induced by changes in altitude. A correlation between pupil dynamics and acute mountain sickness was sought. Seventeen volunteers were studied following acute exposure to 3450 m and then during a trek to 4770 m in Ladakh, India. The pupillometer was used to record maximum and minimum pupil diameter in response to a standard light source with calculation of latency, constriction and dilatation velocities. Acute mountain sickness (AMS) was recorded using Lake Louise self completed questionnaires both in the morning and afternoon on each day. Acute altitude exposure resulted in a significant reduction of percentage change in pupil size (36.5% to 24.1% p=<0.001), significant delay in pupillary contraction (latency; 0.208 to 0.223 seconds p=0.015) and a significant slowing of the rate of contraction (constriction velocity; -2.77 mm/s to -1.75 mm/s p=0.012). These changes reverted to normal during a period of acclimatization. A significant diurnal variation in pupil size was also observed. There was no significant difference between subjects with and without AMS. The handheld pupillometer is a suitable robust tool for monitoring changes in pupil dynamics in the field. With acute exposure to hypobaric hypoxia associated with an ascent to a moderate altitude, there is a general slowing of pupil function which reverts to normal within a few days of acclimatization. There appears to be a marked diurnal variation in pupil size. The measurements clearly demonstrated an effect of hypoxia on cerebral function, but these changes did not relate to moderate AMS.
Conservation of orbital angular momentum in air-core optical fibers: erratum (2017)

We provide additional details on the bend perturbation calculation necessitated by labelling errors in Fig. 3(a) of Optica2, 267 (2015)OPTIC82334-253610.1364/OPTICA.2.000267, and provide one citation missing from the original manuscript.
Magnetically Levitated Linear Stage With Linear Bearingless Slice Hysteresis Motors (2020)

This article presents the design, construction, modeling, and testing of a novel magnetically levitated linear stage using a linear bearingless slice motor design, targeting in-vacuum transportation tasks in precision manufacturing systems. The stage is driven by novel linear hysteresis motors, where the motor secondaries are made of magnetically semihard material exhibiting magnetic hysteresis. The suspension of the stage in three degrees of freedom, including vertical, pitch, and roll, is achieved passively through permanent magnet bias flux. The suspension in the lateral and yaw directions is actively controlled. This compact design effectively reduces the number of sensors and actuators needed for stabilizing the levitation. The prototype stage has been successfully levitated with a maximum thrust force of 5.8 N under 2.5-A current amplitude, which generates a stage acceleration of 1200 mm/s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The stage position control loop has a bandwidth of 30 Hz. The stage is tested to track a reference trajectory of the target application, and the maximum position tracking error is 50 μm. The stage's lateral displacement during motion is below 50 μm, which is well below making mechanical contact to the side walls. To our knowledge, this article presents the first linear bearingless slice motor design, and also the first study on linear versions of hysteresis motors.
Experimental demonstration of optical 5-Gb/s 16-QAM OFDM signal generation and wavelength reuse for 1.25-Gbit/s uplink signal (2008)

5 Gb/s 16 QAM OFDM signal for ROF downstream link and 1.25 Gb/s OOK signal via RSOA for upstream link are demonstrated. Negligible penalty is observed after 25 km SMF.
Augmented Grad-CAM: Heat-Maps Super Resolution Through Augmentation (2020)

We present Augmented Grad-CAM, a general framework to provide a high-resolution visual explanation of CNN outputs. Our idea is to take advantage of image augmentation to aggregate multiple low-resolution heat-maps - in our experiments Grad-CAMs - computed from augmented copies of the same input image. We generate the high-resolution heat-map through super-resolution, and we formulate a general optimization problem based on Total Variation regularization. This problem is entirely solved on the GPU at inference time, together with image augmentation. Augmented Grad-CAM outperforms Grad-CAM in weakly supervised localization on Imagenet dataset, and provides more detailed heat-maps. Moreover, Augmented Grad-CAM turns to be particularly useful in monitoring the production of silicon wafers, where CNNs are employed to classify defective patterns on the wafer surface to detect harmful faults in the production line.
A dual branch Hammerstein-Wiener architecture for behavior modeling of wideband RF transmitters (2010)

This paper proposes a dual branch Hammerstein-Wiener system suitable for behavioral modeling of dynamic nonlinear RF power amplifiers and transmitters. The model consists of a Hammerstein system in parallel with a Wiener system. The model performances in time and frequency domains are experimentally evaluated for a 3G high power Doherty amplifier driven by multi-carrier WCDMA signals. For various orders, the performances of the proposed dual branch Hammerstein-Wiener model are benchmarked against those of the Hammerstein model, Wiener model, and the well established memory polynomial model. The proposed dual branch model achieves better performance than single branch Wiener and Hammerstein models with higher number of coefficients. Furthermore, it leads to normalized mean square error performance comparable to that of the memory polynomial model while requiring 30% to 40% less coefficients.
ChemInform Abstract: Regiospecific Bromination of 3‐Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of macrophage markers by a population of T cells obtained from synovial fluid of a subgroup of patients with juvenile rheumatoid arthritis. (1998)

Our data indicate that a population of T cells obtained from the SF of a subgroup of patients with JRA exhibited characteristics of macrophages, yet retained their CD3 and T cell receptor expression. Whether this promiscuous behavior is caused by malignant transformation of lymphoid precursor cells or is induced by the concerted effect of a myriad of cytokines and growth factors present in the SF remains unknown. The presence of these cells in the SF of 2 patients with JRA with different onset types raises the question of their function and significance in an autoimmune disorder such as JRA.
Work place based assessment in foundation year: Foundation University Medical College experience. (2013)

WPBA offers the opportunity to connect teaching, learning and assessment. More studies on WPBA in different departments of hospitals are required to be carried out in order to overcome the deficiencies and to improve the assessment methods.
Development of a Sensitive Indirect Chromatographic Method to Characterize Iodine Monochloride (1997)

Abstract A highly specific indirect method for the analysis of iodinemonochloride (ICl) has been developed to assess the potential for minor chlorination side reactions when using ICl to iodinate an aniline derivative. The technique offers great advantages over the non-specific thiosulfate titrimetric method commonly used to characterize IC1 and differentiates samples previously thought to be identical. The method described in this paper uses a simple and rapid “bench top” analytical laboratory version of the formal iodination reaction as a pre-HPLC sample derivatization, followed by detection of the chlorinated aniline analogues. The derivatization method mimics the ability of the formal reaction to predict the chlorination potential of IC1 samples with varying levels of excess chlorine. The principles used for this specific application should be suitable for related iodination reactions as long as a suitable laboratory derivatization reaction can be developed.