gebhart/patrepeval huggingface dataset:
Abstract 2414: Interrogating cellular metabolism reveals mTORC2 as a new biomarker to stratify epidermal growth factor receptor-mutant non-small cell lung cancer (2018)

Abstract Most non-small cell lung cancer (NSCLC) patients with epidermal growth factor (EGFR) mutations initially respond to EGFR tyrosine-kinase inhibitors (TKIs), but these inhibitors are only effective for approximately one year, thus limiting the benefits to patients' survival. Stratification of patients with EGFR-mutant NSCLC would help physicians personalize and optimize patient treatment plans. To this end, we hypothesized that factors residing in the tumor microenvironment play a pivotal role in the evolutionary dynamics of therapeutic response to anti-EGFR therapies. We used the Operetta® High Content Imaging System to track cell dynamics over time under different microenvironmental stresses, and we found that the growth of TKI-resistant cells is more sensitive to glucose starvation than TKI-sensitive cells. To further interrogate cellular metabolism in TKI-sensitive and resistant cells, we utilized both seahorse metabolic assays and fluorescence lifetime imaging microscopy to monitor the changes in glycolysis and oxidative phosphorylation of living cells. We found TKI-resistant cells have higher glycolysis and lower oxidative phosphorylation rates compared to TKI-sensitive cells. Such metabolic reprogramming rendered TKI-resistant cells with lower metabolic plasticity to cope with metabolic stress. Using both genetic and pharmacologic approaches, we then demonstrated that mTORC2 activation contributes to the different metabolic phenotypes between TKI-sensitive and resistant cells. Furthermore, gene set enrichment analysis showed that the oxidative phosphorylation gene set is significantly enriched in patients with low mTORC2 activation, and the glycolysis gene set is upregulated in patients with high mTORC2 activation, which is correlated with shorter progression-free and overall survival time in patients. Overall, these data suggest that TKI-resistant cells use and require distinct metabolic programs that can be employed to stratify EGFR-mutant NSCLC patients for treatment with EGFR-TKIs. Citation Format: Chun-Te Chiang, Nolan Ung, Alexandra N. Demetriou, Chi-Li Chiu, Niha Choudhury, Cosimo Arnesano, Scott E. Fraser, David B. Agus, Naim Matasci, Dan L. Ruderman, Shannon M. Mumenthaler. Interrogating cellular metabolism reveals mTORC2 as a new biomarker to stratify epidermal growth factor receptor-mutant non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2414.
Reduced efficiency droop of nonpolar a-plane (11-20) GaN-based light-emitting diodes by vertical injection geometry (2016)

Vertical nonpolar a-plane (11-20) InGaN/GaN light-emitting diodes (LEDs) have been demonstrated by using laser lift-off technique. The forward voltage of the a-plane vertical LEDs was 4.3 V at 350 mA, which was reduced by 0.8 V compared to that of the a-plane lateral LEDs. The vertical geometry of the a-plane LEDs produced the higher quantum efficiency with a low efficiency droop and also enhanced the output power by more than 40%, when compared to those of a-plane lateral LEDs. These results can be attributed to the high thermal dissipation as well as uniform current spreading of the vertical geometry of the a-plane LEDs. Furthermore, elimination of the highly defected GaN nucleation layer after removing the sapphire substrates during the fabrication process can also enhance current injection efficiency, followed by the increase in the output power.
Platelet-Derived Growth Factor: : Normal Function, Role in Disease, and Application of PDGF Antagonists (2005)

Platelet-derived growth factor (PDGF) is a family of isoforms that stimulate the growth, survival, and motility of fibroblasts, smooth muscle cells, and other cell types. PDGF was originally identified in human platelets and purified from this source; however, subsequent studies have shown that PDGF is synthesized by a number of different cell types. PDGF has important roles in the regulation of growth and differentiation of various mesenchymal cell types during embryonal development. In the adult, PDGF stimulates wound healing and also regulates the homeostasis of the connective tissue compartment. Overactivity of PDGF or constitutive activation of PDGF receptors has been implicated in several disorders, including malignancies, atherosclerosis, and fibrotic conditions. Therefore, much effort has recently been devoted to the development of specific and efficient PDGF antagonists. This review will focus on the validation of PDGF antagonists in animal models and on the initial clinical studies in which PDGF antagonists have been used to treat patients.
Transcriptional downregulation of the lactase (LCT) gene during childhood (2005)

Pancreatic neurogenic tumours are extremely rare. 1
Hemispherical focal plane detector arrays (2008)

We demonstrate a 10 kilopixel passive matrix focal plane array consisting of (40mum) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> organic double heterojunction photodetectors on a 1cm radius plastic hemisphere that mimics the size and architecture of human eye.
Abstract 17805: Gut Microbiota Promote Arterial Hypertension and Vascular Dysfunction by Facilitating Remote Interleukin-17 Signaling (2015)

Background: The presence of gut microbiota is essential for proper function of the immune cells. Its impact on the blood pressure regulation and systemic vascular function - processes that are described to be immune cell regulated - is unknown. Methods and Results: Unchallenged germfree mice (GF) showed no differences in endothelial function or vascular oxidative stress compared to conventionally reared mice (CONV-R), but they provided a dampened systemic T-bet / Interferon gamma (IFNγ) skewing in lymphoid cells. Re-colonization of GF with regular gut microbiota (conventionally-derived, CONV-D) normalized this phenotype. Angiotensin II (1mg/kg/d for 7d)-infused GF mice showed reduced oxidative stress levels in the vasculature, attenuated vascular expression of monocyte chemoattractant protein-1 and iNOS, blocked systemic up-regulation of T-bet / IFNγ and retinoic-acidreceptor-related orphan receptor-γt (ROR-γt) / interleukin-17 (IL-17) signaling in lymphoid cells and protection from endothelial dysfunction compared to CONV-R mice. Flow cytometric analysis showed a reduced infiltration of Ly6G+ neutrophils into the vessel wall and consequently we found an attenuation of arterial hypertension in Angiotensin II infused GF mice compared to Angiotensin II infused CONV-R mice. Protection from Angiotensin II induced vascular injury and the IFNγ / Ly6C+ monocyte axis as well as the IL-17/Ly6G+ axis was reversed in CONV-D mice. Conclusion: Gut microbiota seem to facilitate Angiotensin II induced hypertension by supporting a T-bet / IFNγ and ROR-γt / IL-17 driven vascular inflammation with infiltration of Ly6G+ neutrophils.
Distributed Monitoring of Robot Swarms with Swarm Signal Temporal Logic (2020)

In this paper, we develop a distributed monitoring framework for robot swarms so that the agents can monitor whether the executions of robot swarms satisfy Swarm Signal Temporal Logic (SwarmSTL) formulas. We define generalized moments (GMs) to represent swarm features. A dynamic generalized moments consensus algorithm (GMCA) with Kalman filter (KF) is proposed so that each agent can estimate the GMs. Also, we obtain an upper bound for the error between an agent's estimate and the actual GMs. This bound is independent of the motion of the agents. We also propose rules for monitoring SwarmSTL temporal and logical operators. As a result, the agents can monitor whether the swarm satisfies SwarmSTL formulas with a certain confidence level using these rules and the bound of the estimation error. The distributed monitoring framework is applied to a swarm transporting supplies example, where we also show the efficacy of the Kalman filter in the dynamic generalized moments consensus process.
Site-directed chemical modification and crosslinking of a monoclonal antibody using equilibrium transfer alkylating crosslink reagents (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-directed chemical modification and crosslinking of a monoclonal antibody using equilibrium transfer alkylating crosslink reagentsFrederick A. Liberatore, Robert D. Comeau, James M. McKearin, Daniel A. Pearson, Benjamin Q. Belonga, III, Stephen J. Brocchini, John Kath, Terri Phillips, Kira Oswell, and Richard G. LawtonCite this: Bioconjugate Chem. 1990, 1, 1, 36–50Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/bc00001a005https://doi.org/10.1021/bc00001a005research-articleACS PublicationsRequest reuse permissionsArticle Views862Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanostructured Wood Hybrids for Fire-Retardancy Prepared by Clay Impregnation into the Cell Wall (2017)

Eco-friendly materials need "green" fire-retardancy treatments, which offer opportunity for new wood nanotechnologies. Balsa wood (Ochroma pyramidale) was delignified to form a hierarchically structured and nanoporous scaffold mainly composed of cellulose nanofibrils. This nanocellulosic wood scaffold was impregnated with colloidal montmorillonite clay to form a nanostructured wood hybrid with high flame-retardancy. The nanoporous scaffold was characterized by scanning electron microscopy and gas adsorption. Flame-retardancy was evaluated by cone calorimetry, whereas thermal and thermo-oxidative stabilities were assessed by thermogravimetry. The location of well-distributed clay nanoplatelets inside the cell walls was confirmed by energy-dispersive X-ray analysis. This unique nanostructure dramatically increased the thermal stability because of thermal insulation, oxygen depletion, and catalytic charring effects. A coherent organic/inorganic charred residue was formed during combustion, leading to a strongly reduced heat release rate peak and reduced smoke generation.
Autonomous Fault Detection with Carrier-Phase DGPS for Shipboard Landing Navigation (2004)

ABSTRACT: This research focuses on airborne integrity algorithms for shipboard relative GPS (SRGPS) navigation. Airborne autonomous detection is required for navigation threats that are undetectable by integrity monitors at a shipboard differential reference station. These threats can be separated into two basic categories: (1) aircraft receiver failures, and (2) signal-in-space anomalies whose effects depend on the displacement between the user and the ship. For the anticipated carrier-phase SRGPS navigation architecture, tracking-loop cycle slips are well-known threats in the first category. Ionospheric gradient and satellite orbit ephemeris anomalies are relevant threats of the second type. Airborne autonomous monitoring algorithms to detect these threats are described in this paper. Monitor performance is directly evaluated relative to the integrity requirements for aircraft shipboard landing navigation applications.
The Characteristics of Peptide Collision-Induced Dissociation Using a High-Performance MALDI-TOF/TOF Tandem Mass Spectrometer (1999)

A new matrix-assisted laser desorption/ionization (MALDI) time-of-flight/time-of-flight (TOF/TOF) high-resolution tandem mass spectrometer is described for sequencing peptides. This instrument combines the advantages of high sensitivity for peptide analysis associated with MALDI and comprehensive fragmentation information provided by high-energy collision-induced dissociation (CID). Unlike the postsource decay technique that is widely used with MALDI-TOF instruments and typically combines as many as 10 separate spectra of different mass regions, this instrument allows complete fragment ion spectra to be obtained in a single acquisition at a fixed reflectron voltage. To achieve optimum resolution and focusing over the whole mass range, it may be desirable to acquire and combine three separate sections. Different combinations of MALDI matrix and collision gas determine the amount of internal energy deposited by the MALDI process and the CID process, which provide control over the extent and nature of the fragment ions observed. Examples of peptide sequencing are presented that identify sequence-dependent features and demonstrate the value of modifying the ionization and collision conditions to optimize the spectral information.
Severe Acute Respiratory Syndrome: Correlation between Clinical Outcome and Radiologic Features (2004)

More extensive airspace disease at presentation is an independent predictor of adverse outcome in patients with SARS.
Preparing small‐dose red cell concentrates (RCCs) for neonatal and pediatric transfusions: Impact of RCC volume, storage, and irradiation (2022)

Non-irradiated small-aliquot dose RCCs meet in vitro quality criteria required for safe transfusion throughout the 42-day storage period. The same can be said for aliquots derived from irradiated units and tested within 24 h of aliquot production.
Ex vivo biomechanical, functional, and immunohistochemical alterations of adrenergic responses in the female urethra in a rat model of birth trauma (2010)

Birth trauma and pelvic injury have been implicated in the etiology of stress urinary incontinence (SUI). This study aimed to assess changes in the biomechanical properties and adrenergic-evoked contractile responses of the rat urethra after simulated birth trauma induced by vaginal distension (VD). Urethras were isolated 4 days after VD and evaluated in our established ex vivo urethral testing system that utilized a laser micrometer to measure the urethral outer diameter at proximal, middle, and distal positions. Segments were precontracted with phenylephrine (PE) and then exposed to intralumenal static pressures ranging from 0 to 20 mmHg to measure urethral compliance. After active assessment, the urethra was rendered passive with EDTA and assessed. Pressure and diameter measurements were recorded via computer. Urethral thickness was measured histologically to calculate circumferential stress-strain response and functional contraction ratio (FCR), a measure of smooth muscle activity. VD proximal urethras exhibited a significantly increased response to PE compared with that in controls. Conversely, proximal VD urethras had significantly decreased circumferential stress and FCR values in the presence of PE, suggesting that VD reduced the ability of the proximal segment to maintain smooth muscle tone at higher pressures and strains. Circumferential stress values for VD middle urethral segments were significantly higher than control values. Histological analyses using antibodies against general (protein gene product 9.5) and sympathetic (tyrosine hydroxylase) nerve markers showed a significant reduction in nerve density in VD proximal and middle urethral segments. These results strongly suggest that VD damages adrenergic nerves and alters adrenergic responses of proximal and middle urethral smooth muscle. Defects in urethral storage mechanisms, involving changes in adrenergic regulation, may contribute to stress urinary incontinence induced by simulated birth trauma.
Remotely Positioned MetaSurface-Drone Attack (2023)

We demonstrate for the first time security vulnerabilities of wireless backhaul links to aerial metasurfaces. Considering over-the-air threats and a strong adversary, we define and experimentally demonstrate the "Remotely Positioned MetaSurface-Drone" (RMD) attack. In the attack, the adversary Eve remotely approaches hard-to-reach wireless backhaul links, e.g., between towers and rooftops, and stealthily manipulates highly directive backhaul transmissions on-the-fly, enabling remote eavesdropping. To realize the attack, she designs a lightweight power-free transmissive on-drone diffractive metasurface. Exploring the foundations of the attack, we show how Eve induces a secret 3D diffraction radiation beam on the intercepted transmission, re-purposing it for eavesdropping. We investigate Eve's bit-error-rate (BER)-driven flight navigation strategy and show how she can adapt the RMD flight pattern to dynamically shape the diffraction radiation beam and consistently improve her signal reception at a remote location. We implement the attack and perform a series of preliminary experiments with wireless links above 100 GHz having multi-GHz-wide bandwidth. Our results reveal that the RMD attacker can intercept backhaul transmissions with nearly zero BER while maintaining minimal impact on legitimate communication.
Wideband Planar Transmission Line Hyperbolic Metamaterial for Subwavelength Focusing and Resolution (2013)

We analyze both theoretically and experimentally subwavelength focusing by using a planar hyperbolic metamaterial (HM) at microwave frequencies. The proposed HM consists of microstrip transmission lines (TLs) loaded by lumped components and exhibits a very flat wave vector iso-frequency dispersion diagram over a wide frequency range, and thus able to transport spectral component with large wavenumbers. This flatness is here exploited to provide subwavelength focusing with a full width half maximum (3-dB power width) of about λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> /31 and λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> /19 at 0.5 and 1 GHz, respectively, where λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> is the guided wavelength in the TL microtrip grid. Numerical simulation results are in good agreement with measurement ones. Moreover, we also investigate the capability of the proposed HM to resolve sources with subwavelength distance of about λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> /6 and λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> /3 at 0.5 and 1 GHz, respectively.
Improving Electromagnetic Bias Estimates (2004)

The derivation of an electromagnetic (EM) bias model that includes the physical optics scattering models and the non-Gaussian long wave surface statistics is presented. The final formulation of the model is expressed as a function of hydrodynamic modulation, surface skewness, and tilt modulation. Through the modulation transfer function, the hydrodynamic modulation coefficient is shown to be equivalent to the long wave RMS slope multiplied by a function of the short wave spectrum. With this result the normalized EM bias reduces to a function of long wave surface parameters with coefficients determined by properties of the short ocean waves. EM bias values are computed from the theory, using a realistic surface PSD, and compared with in situ bias measurements. The bias model is shown to be in excellent agreement with the measured values, and includes features of normalized bias not present in previous models.
Azapenams: An Efficient Approach to a Novel Class of β-Lactams1 (1993)

The Michael adduct of (diphenylmethylene)amine to methyl 2-chloro-2-cyclopropylideneacetate 1 is readily converted to the azidoester 2; the imino group is hydrolyzed and the primary amino group protected with a benzyloxy- or menthyloxycarbonyl group. The azide is reduced with hydrogen sulfide and the second amino group then transformed to the formamidines 5, which cyclize upon heating to the imidazolines 6 in high yields. Irradiation of (dibenzylaminocarbene)pentacarbonylchromium 7 in the presence of 6 then yields azapenams 8 in moderate to good yield as a single diastereomers. With an appropriate combination of protecting groups in the starting materials, the carboxylate function in 8b-Bn can be deprotected selectively to give the free acid 8b-H.
MAREJADAS RURALES Y LUCHA POR LA VIDA, VOL. I:CONSTRUCCIÓN SOCIOCULTURAL Y ECONÓMICA DEL CAMPO. (2019)

INSTITUTO DE CIENCIAS AGROPECUARIAS Y RURALES (ICAR), UNIVERSIDAD DE GUADALAJARA, EL COLEGIO DE MICHOACAN A.C., CUCOSTA SUR GRANA, FACULTAD DE ESTUDIOS SUPERIORES ACATLAN-UNAM, ECOSUR
Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors. (2005)

The purpose of this research was to evaluate the effects of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid (12-MTA) on the VX2 squamous cell carcinoma in rabbits. An intramuscular VX2 squamous cell carcinoma was induced at a single site in the right thigh of 39 New Zealand white rabbits. Approximately 10 days after inoculation, a 3-French catheter was introduced into the right common carotid artery and positioned using fluoroscopic guidance in the right deep femoral artery, which was the main, if not exclusive, artery supplying the tumor. Ethiodol alone (targeting agent), Ethiodol containing 12-MTA, or Ethiodol containing myristic acid was then injected through the catheter. Tumor growth and histopathology were evaluated 7-8 days after treatment. Caspase-3 activity was evaluated 2 days after therapy, and tumor tissues were assayed for eicosanoid metabolites 2 and 7 days after treatment to assess the effects of the branched chain fatty acid on the lipoxygenase (LOX) and cyclooxygenase-2 (COX-2) enzyme systems. Targeted arterial delivery of 12-MTA resulted in dose-dependent growth inhibition of intramuscular rabbit VX2 tumors while myristic acid, a saturated fatty acid of the same carbon length as 12-MTA, was found to stimulate tumor growth. Two and 7 days following treatment, tumors treated with 12-MTA showed a significant decrease in 5-hydroxyeicosatetraenoic acid (5-HETE) and a concomitant increase in 15-HETE levels while tumors treated with myristic acid exhibited a significant increase in prostaglandin E2 (PGE2) levels. Western blot as well as immunohistochemical analysis showed that 5-LOX and COX-2 proteins were present in the VX2 tumors. No alterations in tumor/tumor cell morphology or caspase-3 activity were evident on microscopic examination following treatment. These studies suggest that targeted arterial delivery of branched chain fatty acids such as 12-MTA may be considered as a potential new therapy for treatment of solid tumors. The exact mechanism(s) responsible for the observed inhibition of VX2 tumor growth by 12-MTA is unclear. Additional in vivo studies are warranted to elucidate 12-MTA's mechanism of action and further investigate the branched chain fatty acid's antitumor effects.
Renal replacement therapy intensity for acute kidney injury and recovery to dialysis independence: a systematic review and individual patient data meta-analysis (2017)

Australian New Zealand Clinical Trials Registry (ANZCTR) identifier ACTRN12615000394549 (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12615000394549).