gebhart/patrepeval huggingface dataset:
Differential Role of p38α in the Cardiomyopathy Induced by Either β 1 ‐ or β 2 ‐Adrenergic Receptor Overexpression (2006)

The goal of this study was to determine if p38α MAP kinase is implicated in the cardiomyopathy in transgenic (TG) mice with β 1 ‐ or β 2 ‐ adrenergic receptor (AR) overexpression. We examined mice with β 1 ‐AR and β 2 ‐AR overexpression (β 1 ‐AR TG and β 2 ‐AR TG), which exhibit enhanced left ventricular (LV) function as young adults (4–5 months) but develop impaired LV function and cardiomyopathy as they age and also examined these mice crossed with p38α dominant negative (DN) mice. In β 1 ‐AR TG, 11–15 months, LVEF was reduced, p&lt;0.05, (54 ± 2%) vs WT (70 ± 1%) and cardiac fibrosis as reflected by Picric Sirius Red staining was enhanced (6.9 ± 1.3%) vs WT (0.5 ± 0.4%). Similarly, in β 2 ‐AR TG, 11–15 months, LVEF was reduced, p&lt;0.05, (52 ± 3%) vs WT (70 ± 2%) and cardiac fibrosis was enhanced (5.2 ± 0.4%) vs WT (0.5 ± 0.4%). In bigenic mice, (β 1 ‐AR TG x p38αDN), 11–15 months, LVEF was depressed similarly to β 1 ‐AR TG (55 ± 3%) vs WT (70 ± 1%) and cardiac fibrosis was also not improved (5.9 ± 1.1%) vs WT (0.5 ± 0.4%). In contrast, in bigenic mice (β 2 ‐AR TG x p38αDN), 11–15 months, LVEF was rescued (81 ± 2%) vs WT (70 ± 2%) and cardiac fibrosis was attenuated, p&lt;0.05, (3.5 ± 0.5%) vs WT (0.5 ± 0.4%). These results support the hypothesis that the cardiomyopathy, which develops in mice overexpressing β 1 ‐AR does not involve the adverse effects of enhanced p38α MAP kinase signaling, but the cardiomyopathy which develops in mice overexpressing β 2 ‐AR is mediated, at least in part, by p38α signaling.
Influence of Rotor Position in FRA Response for Detection of Insulation Failures in Salient-Pole Synchronous Machines (2011)

Frequency response analysis (FRA) is a very common test for the diagnosis of power transformers. This paper presents some relevant results on the application of FRA to the diagnosis of rotating machines. First, a reference rotor position for obtaining the reference FRA response of a rotating machine is proposed. Then, FRA with the proposed rotor position is used to identify faults in the stator of the machine. This paper studies turn-to-turn and ground faults in the stator for different fault resistance values. Several laboratory tests demonstrate the applicability and value of the use of FRA in the diagnosis of rotating machines.
Baseline requirements for government and military encryption algorithms (2003)

(U) Foreign government and military organizations are developing formal evaluation criteria for their communications security (COMSEC) procurements. Although many countries have unique requirements, most have a common set of criteria. Due to the value of the information being secured, these criteria are much more comprehensive, rigorous and stringent than the commercial equivalent. It is useful to examine these criteria and use them to construct a threat model and baseline requirements for COMSEC products in military and government applications. This threat model allows customer COMSEC requirements to be more thoroughly understood by equipment providers. The baseline requirements will also provide a set of metrics for evaluating the quality of a COMSEC solution. This paper presents an introduction to threat model assessment. Several example models are provided. A definition and detailed discussion of a government/military COMSEC threat model is also presented Finally, the model is used to derive baseline requirements that can be used to design or evaluate a COMSEC solution intended for military and government applications.
Millimeter-Wave Integrated Photoreceivers for High Data Rate Photonic Wireless Communication (2017)

We report on the use of 30 and 100 GHz integrated millimeter-wave photoreceivers in high data rate photonic wireless communication. The role of the bandwidth of a narrow-band photoreceiver in increasing the data rate of wireless single carrier transmission is discussed. An 11-GHz bandwidth photoreceiver achieved a data rate of 44.6 Gb/s using an 8 GBd, 64-QAM (quadrature amplitude modulation) signal. A wider bandwidth (19 GHz) integrated photoreceiver was designed and fabricated for use in the 100-GHz range. High-frequency response photoreceivers have the following advantages: they operate in a wide bandwidth easily, use frequency resources efficiently, and are subject to low amounts of atmospheric attenuation. In addition to the single carrier wireless transmission study, a high data rate (12 Gb/s) multicarrier radio over fiber (16-QAM in orthogonal frequency division multiplexing) transmission experiment was demonstrated in order to confirm the ability to increase the data rate with a wide operational bandwidth.
Role of glutathione reductase in proteostasis regulation (2015)

Trabajo presentado en la V Spanish Worm Meeting, celebrada en Salamanca el 5 y 6 de marzo de 2015.
Learning-Based Resource Allocation: Efficient Content Delivery Enabled by Convolutional Neural Network (2019)

In practical content delivery, when the time-frequency resources are limited, it is a challenging task to satisfy terminals' data demand in a heavy-traffic and mutual-interfered scenario. In this paper, we investigate time-efficient and energy-efficient solutions for content delivery at the network edge. We formulate two resource allocation problems, aiming at minimizing the total transmission time/energy in content delivery. The problems are formulated as mixed-integer linear programming. We obtain the global optimal solution by the branch-and-bound algorithm which typically incurs long computational time. To enable a computationally-efficient solution for fast and high-quality decision making, we resort to learning-based approaches to tackle the difficult combinatorial-optimization part. We investigate two deep-learning approaches, i.e., fully-connected deep neural network (FC-DNN) and convolutional neural network (CNN), to solve the problems. The FC-DNN and CNN are trained to learn and predict the discrete decisions. We compare the performance among FC-DNN, CNN, and the optimal solution. The numerical results illustrate that the proposed learning-based resource allocation approaches can achieve significant timesaving gains in computation and have promising performance in optimality approximation.
Advanced nanostructured materials by design using supercritical fluids (2015)

Invited talk
Organometallic vapor phase epitaxial growth of GaN on ZrN∕AlN∕Si substrates (2008)

An intermediate ZrN∕AlN layer stack that enables the epitaxial growth of GaN on (111) silicon substrates using conventional organometallic vapor phase epitaxy at substrate temperatures of ∼1000°C is reported. The epitaxial (111) ZrN layer provides an integral back reflector and Ohmic contact to n-type GaN, whereas the (0001) AlN layer serves as a reaction barrier, as a thermally conductive interface layer, and as an electrical isolation layer. Smooth (0001) GaN films less than 1μm thick grown on ZrN∕AlN∕Si yield 0002 x-ray rocking curve full width at half maximum values as low as 1230arcsec.
800-nA Process-and-Voltage-Invariant 106-dB PSRR PTAT Current Reference (2013)

This brief presents a novel process-and-voltage-invariant proportional to absolute temperature (PTAT) current reference. The proposed circuit is designed and fabricated in 180-nm mixed-mode CMOS technology. Measurement results show that the IPTAT varies only by ±2.4% (±3σ/mean) across 18 test chips. One thousand Monte Carlo simulation runs show that the maximum deviation (±3σ/mean) from the desired value of the PTAT current is ±5.4%. The proposed PTAT current reference uses a process, voltage, and temperature (PVT)-invariant resistor circuit having R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> variation reduced by 4.2 times, as compared to a fixed biased MOSFET. The proposed PTAT current reference draws only 800-nA current from the supply voltage and also exhibits a high dc power supply rejection ratio (PSRR) of 106 dB. This brief also presents a PVT-invariant transconductance using the implemented PVT-invariant resistor.
Supplemental Figure 2 from Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in Xenograft Models of Neuroblastoma (2023)

&lt;p&gt;Growth of T cells engineered with lentivirus or RNA.&lt;/p&gt;
The Reactivity of Polydiene Anions with Divinylbenzene (1981)

Star-branched homopolymers of butadiene and isoprene have been synthesized utilizing anionic polymerization techniques. The commercial mixture of divinylbenzene was employed as the star linking agent for the "living" polydienyllithium anions. The nature of the star-branching reaction was studied with respect to: the molar ratio of divinylbenzene (DVB)/alkyllithium (RLi), reaction temperature, reaction time and the nature of the polydienyllithium chain end. In general, a higher number of arms is achieved via increased DVB/RLi ratio, reaction temperature and through the choice of polydienyllithium chain ends. The polymers were characterized by gel permeation chromatography (G.P.C.), membrane osmometry, intrinsic viscosity, and H-NMR spectroscopy. A Chromatix low-angle light scattering G.P.C. detector was also employed for the determination of the weight average molecular weight (Mw), as well as a sensitive detector, in order to assay absolutely the Mw versus elution volume profile for a series of star-branched polyisoprenes and polybutadienes. The results indicate that under optimum conditions a relatively well defined number of arms can be achieved with DVB linking.
Opposing effects of trans‐10, cis‐12 conjugated linoleic and cis‐9, trans‐11 linoleic on risk markers of coronary heart disease (2007)

Background: CLA reduced atherosclerosis in animals. Effects of the biologically active isomers CLA on endothelial dysfunctions are of interest. Design : 75 healthy postmenopausal women were given a daily supplement with 4.5 g of oil rich in either cis‐9, trans ‐11 CLA, c9, t11‐ and trans‐10, cis‐12 CLA, or olive oil for 16 weeks in a double‐blind, randomized, parallel intervention study. Blood and urine were sampled before and after. Results: Plasma ratio total cholesterol:HDL cholesterol, high sensitive C‐reactive protein, fibrinogen and plasminogen activator inhibitor were significantly higher during supplementation with trans‐10 cis‐12 CLA than with cis‐9 trans‐11; plasma TAG was higher and HDL cholesterol lower after trans‐10 cis‐12 CLA mix than olive oil control. Both CLA isomers increased in vivo oxidative stress measured as free 8‐iso‐PGF 2α , however trans‐10 cis‐12 CLA in a much more pronounced way. No effects on cytokines, IL‐6 and TNFα, but strong inter‐correlations between inflammatory markers including oxidative stress and inverse correlations with inflammatory markers and HDL cholesterol. Conclusion : Trans‐10 cis‐ 12 CLA has adverse effects on most classical as well as novel CVD markers, whereas 9‐cis trans‐11 CLA isomer appears to be more neutral, except for a slightly increasing effect on oxidative stress compared to olive oil. Support: Danish Dairy Res Found.and Res Devel Program Food Techn.
Effect of Prostate Volume and Minimum Tumor Temperature on 4-Year Quality-of-Life After Focal Cryoablation Compared with Active Surveillance in Men with Prostate Cancer (2022)

<b><i>Background:</i></b> The purpose of this study is to analyze quality-of-life (QoL) metrics in men treated with focal cryoablation (FC) compared with active surveillance (AS) for localized prostate cancer over a 4-year follow-up period. We further investigated the effect of prostate size and minimum tumor temperature on QoL outcomes. <b><i>Methods:</i></b> An Institutional Review Board-approved database was reviewed for patients who underwent FC or AS. QoL questionnaire responses were collected and scores were analyzed for differences between FC and AS, between prostate volume <50 cc and ≥50 cc, and "cold" (<-78°C) and "warm" (≥-78°C) tumor temperatures. <b><i>Results:</i></b> One hundred forty-eight AS and 60 FC patients were included. Compared with AS, no significant difference existed in urinary function (UF) measured by Expanded Prostate Cancer Index Composite (EPIC) (<i>p</i> = 0.593) and International Prostate Symptom Score (IPSS) (<i>p</i> = 0.241), bowel habits (<i>p</i> = 0.370), or anxiety (<i>p</i> = 0.672) across time post-FC. FC had significantly worse sexual function (SF) compared with AS measured by EPIC (<i>p</i> < 0.0001) and International Index of Erectile Function (IIEF) (<i>p</i> < 0.0001). Patients with prostate volume <50 cc did not demonstrate differences between AS and FC in UF on EPIC (<i>p</i> = 0.459) or IPSS (<i>p</i> = 0.628), but FC patients had worse SF on EPIC (<i>p</i> < 0.001) and IIEF (<i>p</i> < 0.001). FC patients with a prostate volume ≥50 cc had better UF measured by IPSS (<i>p</i> < 0.05) and similar SF on EPIC (<i>p</i> = 0.162) and IIEF (<i>p</i> = 0.771) compared with AS. UF over time measured by EPIC (0.825) and IPSS (<i>p</i> = 0.658) was the same between AS, "warm," and "cold" FC groups. AS had significantly better SF than the "warm" and "cold" FC groups on EPIC (<i>p</i> < 0.001) and IIEF (<i>p</i> < 0.05). <b><i>Conclusions:</i></b> No differences were found in anxiety, urinary, or bowel function between AS and FC. Despite differences in SF, patients with larger prostates had no difference in SF and improved UF compared with AS. Future studies with larger cohorts are needed.
Pitting Corrosion Resistance of Ultrafine-Grained Aluminum Processed by Severe Plastic Deformation (2005)

The effect of equal-channel angular pressing (ECAP) on the pitting corrosion resistance of Al and Al-Mg alloy was investigated by means of polarization curves in solutions containing 300 ppm of Cl- and by surface analysis. The potentials for pitting corrosion of Al and Al-Mg alloy were evidently shifted to the noble direction by ECAP process, indicating that this process improves resistance to pitting corrosion. SEM observation revealed that the pitting corrosion occurred near the impurity precipitates and the size of impurity precipitated decreased with ECAP process. The time-dependence of corrosion potential and the polarization resistance determined by AC impedance technique suggested that the formation rate of Al oxide films was increased with ECAP process. The improvement in pitting corrosion resistance of Al and Al-Mg by ECAP seems to be attributable to the decrease in the size of impurity precipitates and the increase in the formation rate of Al oxide films.
Battery Reliability of Fast Electric Vehicle Charging Systems (2021)

Fast electric vehicle charging systems (FEVCSs) are becoming popular, but to assure long-term operation, further research on battery lifetime is necessary. This is because FEVCSs use high charging currents, and consequently subject Li-Ion batteries to high levels of average state of charge (SOC) and temperatures within a short period of time. Thus, degradation mechanisms, such as Lithium plating and electrolyte breakdown, are inevitable in Li-Ion batteries, leading to reduced battery capacity and lifetime. Therefore to investigate the battery reliability of FEVCSs, this paper proposes a two-stage modeling approach. Using the proposed model, the impact of SOC and temperature on the reliability of the battery as well as the reliability of a Li-Ion battery under typical fast EV charging conditions are investigated, and results are presented to show how the battery reliability deteriorates under fast charging conditions.
Levels inPd112andMo102 (1989)

Particle-gamma-ray coincidence spectra from the $^{110}\mathrm{Pd}$(t,p\ensuremath{\gamma}\ensuremath{\gamma}${)}^{112}$Pd and $^{100}\mathrm{Mo}$(t,p\ensuremath{\gamma}\ensuremath{\gamma}${)}^{102}$Mo reactions were measured with enriched $^{110}\mathrm{Pd}$ and $^{100}\mathrm{Mo}$ targets bombarded by 16-MeV tritons to obtain more complete level structures for $^{112}\mathrm{Pd}$ and $^{102}\mathrm{Mo}$. The resultant ground state band of $^{112}\mathrm{Pd}$ and that of $^{120}\mathrm{Xe}$ are used in the interpretation of coexistence in $^{116}\mathrm{Sn}$. The possible observation of backbending in $^{102}\mathrm{Mo}$ is used to investigate the A dependence of backbending over a wider mass region.
Abstract 2070: Differentiating PD-1+TCF-1+ stem-like resource CD8 T cells towards a distinct effector Tcell population with enhanced anti-tumor potential by delivering an engineered IL-2 variant to PD-1 via cis-targeting (2022)

Abstract PD1-IL2v is a novel immunocytokine constituted by a high affinity bivalent blocking PD-1 antibody and a heterodimeric silent Fc-part fused to a monomeric IL-2 variant (IL2v). In contrast to wildtype IL2, IL2v does not bind to CD25 (IL2Ra) and, therefore, the preferential targeting of T regulatory cells (Tregs) and endothelial cells through CD25 is abolished. The PD-1 antibody, having ca. 50-fold higher affinity than IL2v, dictates the preferential cis-delivery of IL2v to PD-1 positive T cells, such as antigen-experienced tumor-reactive T cells. In addition, due to the reduced expression levels of PD-1 on Tregs compared to CD8 and conventional T cells, PD1-IL2v preferentially binds to the latter in vitro and ex vivo, rescuing them from Treg-mediated suppression. To assess the effects of the cis-delivery of IL2v to PD-1+ T cells in vivo, we applied subcutaneous B16F10-OVA and Panc02-H7-Fluc tumor models in syngeneic mice. PD1-IL2v lead to significantly improved survival of the B16F10-OVA tumor bearing and tumor regression in the Panc02-H7-Fluc tumor bearing mice. The OVA-specific CD8 T cells expressed the highest amount of PD-1 in the tumor microenvironment, and PD1-IL2v not only increased the total number of CD8 tumor infiltrating lymphocytes (TILs), but, more importantly, it expanded the OVA-specific T cells. The recently discovered PD-1+ TCF1+ stem-like or resource T cells responsible for the proliferative burst following anti-PD-1 therapy, correlate with clinical responses and better prognosis. However, stem-like T cells ultimately differentiate into terminally exhausted T cells resulting in relapses and tumor growth. Here, we show that PD1-IL2v targets OVA-specific stem-like T cells, and leads to their expansion and differentiation into a unique population of effector CD8 T cells, so-called “fresh and better effectors”. These cells have a distinct phenotypic and molecular signature in addition to diverse TCR clonality in comparison to the terminally exhausted CD8 TILs generated by anti-PD1 therapy alone or in combination with a non-cis targeted FAP-IL2v immunocytokine. Thus, PD1-IL2v is a differentiated immune cell-targeted IL2v, which promotes an effective and long-term anti-tumor immune-response by delivering IL-2v to PD-1+ tumor-specific T cells, like stem-like T cells, and by generating a distinct effector T cell population. Citation Format: Maria Karagianni, Eleni Maria Varypataki, Valeria Nicolini, Christian Münz, Pablo Umana, Christian Klein, Laura Codarri Deak. Differentiating PD-1+TCF-1+ stem-like resource CD8 T cells towards a distinct effector Tcell population with enhanced anti-tumor potential by delivering an engineered IL-2 variant to PD-1 via cis-targeting [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2070.
Tailoring and Cancelling Dispersion of Slow or Stopped and Subwavelength Surface-PlasmonoDielectric-Polaritonic Light (2008)

We present a nanostructured plasmonodielectric material platform, enabling a mechanism to tailor the dispersion of slow/stopped surface-polaritonic light. As special case, unusually-high-order dispersion cancellation is achievable, with great applications in optical buffers and active devices.
The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility (2016)

Several erythropoietin-producing hepatocellular receptor B family (EPHB) and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulation in animal models. We selected 528 single nucleotide polymorphisms (SNPs) within the genes of EPHB6, EFNB2, EFNB3 and GRIP1 in the EPH/EFN signalling system to query the International Blood Pressure Consortium dataset. A SNP within the glutamate receptor interacting protein 1 (GRIP1) gene presented a p-value of 0.000389, approaching the critical p-value of 0.000302, for association with diastolic blood pressure of 60,396 individuals. According to echocardiography, we found that Efnb3 gene knockout mice showed enhanced constriction in the carotid arteries. In vitro studies revealed that in mouse vascular smooth muscle cells, siRNA knockdown of GRIP1, which is in the EFNB3 reverse signalling pathway, resulted in increased contractility of these cells. These data suggest that molecules in the EPHB/EFNB signalling pathways, specifically EFNB3 and GRIP1, are involved blood pressure regulation.
Abstract 2858: Binding characteristics of the immunocytokine hu14.18-IL2 and induction of human effector functions as anticipated mode of action. (2013)

Abstract Immunotherapy of neuroblastoma with anti-GD2 antibodies in combination with interleukin-2 (IL2) emerges as an important treatment option as shown in several clinical trials. In consequence, an antibody-IL2 fusion protein (hu14.18-IL2; immunocytokine) was designed that combines the targeting and effector functions of an anti-GD2 antibody and the immune modulation activity of IL2. In addition to mediation of typical effector functions such as CDC and ADCC this immunocytokine targets IL2 to GD2+ tumor cells and thereby links tumor cells to IL2-receptor bearing effector cells via an Fc-gamma independent mechanism. This concept has already shown encouraging results in Phase I/II trials in relapsed/refractory neuroblastoma patients. Here, we report the antigen binding characteristics and in vitro anti-neuroblastoma activity of a new GMP preparation of hu14.18-IL2 (APN301). Binding of APN301 to its nominal antigen GD2 was analyzed by solid phase ELISA and compared to other antibodies of the 14G2a family. Affinities of APN301 to GD2 and to anti-14.18 anti-idiotype antibodies were also determined by Biacore® analysis. GD2 specific ADCC, CDC and whole blood cytotoxicity were analyzed in cytotoxicity assays in vitro (calcein-release, 51Cr release) using GD2+ neuroblastoma target cell lines. We demonstrate similar binding characteristics of APN301 to GD2 compared to parent 14.18 antibodies (murine and chimeric). The anti-14.18 anti-id antibody ganglidiomab fully inhibits binding of APN301 to the nominal antigen GD2, thereby proving internal image properties. The dissociation constants of APN301 to GD2 and ganglidiomab as determined in Biacore analyses are in the 10-9M and 10-7M range, respectively, similar to those determined for the naked chimeric 14.18 antibody. Relevant for the prediction of clinical activity we demonstrate potent specific lysis of GD2+ human neuroblastoma cells mediated by APN301 in a whole blood cytotoxicity assay in vitro, utilizing whole blood of healthy donors as well as whole blood of high-risk neuroblastoma patients in advanced disease stage. Further clinical trials with APN301 in neuroblastoma patients are being planned, taking into account the found potent whole blood cytolytic activity and the pharmakokinetic properties of this immunocytokine. Citation Format: Hans Loibner, Manfred Schuster, Evelyne Janzek, Stefan Stranner, Bernhard Peball, Susanne Wiederkum, Oliver Mutschlechner, Nikolai Siebert, Holger Lode. Binding characteristics of the immunocytokine hu14.18-IL2 and induction of human effector functions as anticipated mode of action. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2858. doi:10.1158/1538-7445.AM2013-2858 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.