gebhart/patrepeval huggingface dataset:
Dielectrically Loaded HTS Spiral Antenna (2004)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Ramasamy, D. Hanna, Y. A. Vlasov, G. L. Larkins, B. H. Moeckly; Dielectrically Loaded HTS Spiral Antenna. AIP Conf. Proc. 28 June 2004; 711 (1): 740–746. https://doi.org/10.1063/1.1774637 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A carbon nanotube structure for an EUV window with differential pumping (2020)

We report on a large-area, high-aspect-ratio, carbon nanotube (CNT) forest structure produced at BYU acting as a window/separator for a hollow cathode EUV lamp. The structure has large-surface-area, high light trans-mission, and differential pumping. CNT fabrication allows for variable dimensions, which allows various EUV distributions and pressure gradients to be possible. Theory is presented for predicting such distributions and gradients. Several structures have been fabricated; their dimensions, properties, and predicted distributions and gradients are given.
A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands (2003)

Multiple genes, interacting with the environment, contribute to the susceptibility to type 2 diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes in a recently genetically isolated population in the Netherlands. We identified 79 nuclear families with type 2 diabetes who were related within 13 generations and performed a 770-marker genome-wide scan search for shared founder alleles. Twenty-six markers yielded a logarithm of odds (LOD) score >0.59 (nominal P < 0.05), of which 7 reached LOD scores >1.17 (nominal P < 0.01). The strongest evidence for a type 2 diabetes locus was at marker D18S63 on chromosome 18p (LOD 2.3, P = 0.0006). This region was investigated further using additional markers. For one of these markers (D18S1105), we found a significant association with type 2 diabetes (odds ratio 6.7 [95% CI 1.5-30.7], P = 0.005 for the 97-bp allele, assuming a dominant model), which increased when limiting the analysis to patients with high BMI (12.25 [2.1-71], P = 0.003). A locus on chromosome 18p in patients with high BMI was suggested earlier by Parker et al. Our study is the first to confirm this locus.
Application of WBG Power Devices in Future 3-Φ Variable Speed Drive Inverter Systems "How to Handle a Double-Edged Sword" (2020)

Latest research results on three-phase wide-bandgap (WBG) inverter systems with full-sinewave output voltage filtering are reported. A new soft-switching modulation scheme for two-level 1200 V SiC inverters is described. Furthermore, a new Figure-of-Merit for determining maximum multi-level (ML) bridge-leg efficiency is defined and low-voltage GaN devices are evaluated considering ML flying capacitor (FC) and multi-cell inverter structures. Finally, new integrated-filter buck-boost current DC-link inverter topologies are discussed.
Effets de la Substitution Captodative XXX1. Addition Des Radicaux Dérivés de Cétones, D'Aldéhydes et de Formiates À L'α‐Tert‐Butylthioacrylonitrile2 (1984)

Abstract Oxydation of ketones, aldehydes and formiates in the presence of radicophilic olefin α‐tert‐butylthioacrylonitrile 3 with captodative (cd) substitution does not give the usual radical decay products: The radical adducts dimerize, thus building a four carbon‐bridge between the original radicals R°.
Observation of Long-Range Orientational Order in Monolayers of Polydisperse Colloids (2006)

Polydisperse amorphous-silicon colloidal particles ranging from approximately 10 to 140 nm in diameter were evaporated onto carbon substrates. The particles formed close-packed monolayers in which each particle had 6-fold nearest-neighbor coordination characteristic of a hexagonal lattice yet completely lacked positional order. Orientational correlation functions were calculated for the particles and found to be constant throughout the aggregate, indicating the occurrence of long-range orientational order. Computer simulations revealed that the structural organization in this system resulted from capillary immersion forces that lead to a size separation as the particles deposit from the evaporating solvent onto the substrate.
Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation (2012)

Nutlin-3 is a novel small-molecule antagonist of the human homolog of mouse double minute (MDM2) that binds MDM2 in the p53-binding pocket and activates the p53 signaling pathway. In this study, we show that nutlin-3 sensitizes Caki human renal cancer cells, but not normal human skin fibroblast (HSF) cells or human mesangial cells, to TRAIL-mediated apoptosis. Combined treatment with nutlin-3 and TRAIL markedly induces apoptosis in HCT116 cells (p53 wild type), but not in HCT116 p53-/- cells, suggesting that p53 is critical for the sensitizing effect of nutlin-3 on TRAIL-induced apoptosis. Pretreatment with N-acetylcysteine (NAC) significantly inhibited nutlin-3-induced DR5 upregulation and cell death induced by the combined treatment with nutlin-3 and TRAIL, suggesting that reactive oxygen species (ROS) mediate nutlin-3-induced DR5 upregulation, which contributes toward TRAIL-mediated apoptosis. However, the upregulation of the p53-mediated protein p53 upregulated modulator of apoptosis (PUMA) by nutlin-3 is likely to be ROS independent because antioxidants failed to block PUMA upregulation. Interestingly, a combined treatment with NAC and PUMA small interfering RNAs significantly blocks nutlin-3-induced and TRAIL-induced apoptosis. Therefore, the present study shows that nutlin-3 enhances TRAIL-induced apoptosis in human renal cancer cells by ROS-mediated or p53-mediated DR5 upregulation and p53-induced PUMA upregulation. These results may offer a novel therapeutic approach to TRAIL-based cancer therapy.
Ultrafast transferred-substrate heterojunction bi-polar transistor ICs for high-speed fiber-optic transmission (2002)

Summary form only given. Heterojunction bipolar transistors (HBTs) are used in Gbit/s fiber-optic ICs, GHz analog-digital converters and microwave PLLs. For 50-GHz clock rates and beyond, transistor bandwidths of several hundred GHz are required. Increased bandwidths in CMOS VLSI and III-V high electron mobility field effect transistors (HEMTs) have been achieved by scaling device lithographic dimensions. In contrast, conventional double mesa HBT bandwidth has not increased with reduced lithographic dimensions due to non-scalable collector-base capacitance. We have developed a transferred substrate HBT process, with significant changes to the device structure that render the device scalable. The process also has significant potential advantages in low parasitic wiring environment, microstrip ground plane, low thermal impedance for high-power operation and increased packing density. HBTs with f/sub max/ >400 GHz have been demonstrated and 50-GHz bandwidth feedback amplifiers have been fabricated. Some medium scale ICs like decision circuits, multiplexer/demultiplexer circuits and variable gain amplifiers are currently under development. Target applications include 100-Gbit/s fiber transmission, microwave analog-digital converters and mm-wave frequency synthesis.
Neuroprotective Efficacy of a Proneurogenic Compound after Traumatic Brain Injury (2013)

Traumatic brain injury (TBI) is characterized by histopathological damage and long-term sensorimotor and cognitive dysfunction. Recent studies have reported the discovery of the P7C3 class of aminopropyl carbazole agents with potent neuroprotective properties for both newborn neural precursor cells in the adult hippocampus and mature neurons in other regions of the central nervous system. This study tested, for the first time, whether the highly active P7C3-A20 compound would be neuroprotective, promote hippocampal neurogenesis, and improve functional outcomes after experimental TBI. Sprague-Dawley rats subjected to moderate fluid percussion brain injury were evaluated for quantitative immunohistochemical and behavioral changes after trauma. P7C3-A20 (10 mg/kg) or vehicle was initiated intraperitoneally 30 min postsurgery and twice per day every day thereafter for 7 days. Administration of P7C3-A20 significantly reduced overall contusion volume, preserved vulnerable anti-neuronal nuclei (NeuN)-positive pericontusional cortical neurons, and improved sensorimotor function 1 week after trauma. P7C3-A20 treatment also significantly increased both bromodeoxyuridine (BrdU)- and doublecortin (DCX)-positive cells within the subgranular zone of the ipsilateral dentate gyrus 1 week after TBI. Five weeks after TBI, animals treated with P7C3-A20 showed significantly increased BrdU/NeuN double-labeled neurons and improved cognitive function in the Morris water maze, compared to TBI-control animals. These results suggest that P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI. We propose that the chemical scaffold represented by P7C3-A20 provides a basis for optimizing and advancing new pharmacological agents for protecting patients against the early and chronic consequences of TBI.
Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive (2012)

Mast cell leukemia (MCL) is a rare and aggressive disease with poor prognosis and short survival time. D816V c-KIT mutation is the most frequent molecular abnormality and plays a crucial role in the pathogenesis and development of the disease. Thus, comprehensive diagnostic investigations and molecular studies should be carefully carried out to facilitate the therapeutic choice. A MCL patient's case with rare phenotypic and genotypic characteristics is described with review of major clinical biological and therapeutic approaches in MCL.
Antibacterial and Antibiofilm Activities of Weissella cibaria CHK903 Against Proteus mirabilis (2023)

This study aimed to identify and characterize lactic acid bacteria strains with antimicrobial activity against Proteus mirabilis, a gram-negative bacterium associated with Parkinson’s disease, Crohn’s disease, and nosocomial infections. Among the 987 lactic acid bacteria strains isolated from various sources, strain no. CHK903 showed high antimicrobial activity against P. mirabilis. Phylogenetic tree analysis based on the 16S rRNA gene and scanning electron microscope analysis identified the selected strain as the rod-shaped Weissella cibaria. The culture supernatants of W. cibaria CHK903 showed antimicrobial activity against some pathogens. Two antimicrobial compounds with molecular weights 189 and 365 Da were partially purified from the culture supernatants of W. cibaria CHK903 using Biogel P2 gel permeation column chromatography. The culture supernatants of W. cibaria CHK903 also showed significant antibiofilm properties, inhibiting biofilm formation by 90% and removing pre-formed biofilms by 60%. These findings suggest the potential therapeutic use of W. cibaria CHK903 as a natural antimicrobial against P. mirabilis-related infections.
Oxygen production for the synfuels industry (1982)

While the synfuels industry is in its early stages, each commercial facility will pioneer key conversion processes and integration concepts. Since the oxygen plant will be the largest internal consumer of energy and will represent a significant portion of capital investment, it must be considered a key process and thus merits substantial attention. The efficiency of each synfuels facility will be greatly enhanced by integrating an oxygen plant that has been optimized regarding processes, equipment, and options necessary to provide a carefully predetermined product mix, product capacity, and product purity. This optimization can be realized if synfuels plant designers and oxygen plant suppliers understand each others needs and work together throughout the design phase.
Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update (2013)

This document is an update to the 2008 publication of the Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Protocols. Since the time of the original publication, 3 additional task forces (Reporting, Post-Processing, and Congenital Heart Disease) have published documents that should be referred to in conjunction with the present document. The section on general principles and techniques has been expanded as more of the techniques common to CMR have been standardized. There is still a great deal of development in the area of tissue characterization/mapping, so these protocols have been in general left as optional. The authors hope that this document continues to standardize and simplify the patient-based approach to clinical CMR. It will be updated at regular intervals as the field of CMR advances.
The Heme Oxygenase-1-Targeting Compound PEG-ZnPP Inhibits Growth of Imatinib-Resistant BCR/ABL-Transformed Cells. (2004)

Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the BCR/ABL oncogene and an increased survival of leukemic cells. The BCR-ABL tyrosine kinase inhibitor imatinib has successfully been introduced as a treatment of CML. However, resistance after an intitial response is common in patients with advanced disease, and it is not yet clear if responses in early disease phases will be durable. Therefore, current studies focus on novel potential drug-targets in CML cells. We have recently identified heme oxygenase-1 (HO-1) as a novel BCR/ABL-dependent survival-molecule in primary CML cells. In this study, we analyzed signal transduction pathways underlying BCR/ABL-induced expression of HO-1 and evaluated the role of HO-1 as a potential new target of drug therapy. We found that the PI3-kinase inhibitor LY294002 and MEK inhibitor PD98059 downregulate expression of HO-1 in CML cells. In addition, constitutively active Ras- and Akt -mutants were found to promote expression of HO-1 in Ba/F3 cells, further supporting the involvement of the PI3-kinase/Akt as well as the MAPK pathway in regulating HO-1 expression. To establish a role for HO-1 in survival of CML cells, expression of HO-1 was silenced by siRNAs which resulted in apoptosis of K562 cells. Next, HO-1 was targeted in CML cells by pegylated zinc protoporphyrin (PEG-ZnPP), a competitive inhibitor of HO-1. Exposure to PEG-ZnPP resulted in growth inhibition and induction of apoptosis in primary CML cells as well as in the CML-derived cell lines K562 and KU812 with IC50 values ranging between 1–10 μM. The growth-inhibitory effects of PEG-ZnPP were not only observed in CML cells responsive to imatinib, but also in imatinib-resistant K562 cells and Ba/F3 cells expressing various imatinib-resistant mutants of BCR/ABL (T315I, E255K, M351T, Y253F, Q252H, H396P). Moreover, imatinib and PEG-ZnPP were found to exert synergistic growth inhibitory effects on imatinib-resistant leukemic cells. Together, these data suggest that HO-1 represents a novel drug target in cells expressing BCR/ABL, including those with resistance to imatinib.
Using Outage History to Exclude High-Risk Satellites from GBAS Corrections (2012)

GNSS augmentation systems that provide integrity guarantees to users typically assume that all GNSS satellites have the same failure probability. The assumed failure probability is conservative such that variations among satellites in a given GNSS constellation are not expected to violate this assumption. A study of unscheduled GPS satellite outages from 1999 to 2011 shows that, as expected, older satellites are much more likely to fail than younger ones. In addition, satellites that have recently experienced unscheduled outages are more likely to suffer additional unscheduled outages. Combining these two factors suggests that it is possible for a subset of GPS satellites to violate the overall satellite failure probability assumption, although this has not yet been demonstrated. Potential rules for GPS satellite exclusion based upon satellite age and recent outages are investigated, and suggestions for including satellite geometry are explored. Copyright © 2012 Institute of Navigation.
Search for gravitational waves associated with the gamma ray burst GRB030329 using the LIGO detectors (2005)

We have performed a search for bursts of gravitational waves associated with the very bright gamma ray burst GRB030329, using the two detectors at the LIGO Hanford Observatory. Our search covered the most sensitive frequency range of the LIGO detectors (approximately $80--\ensuremath{-}2048\text{ }\mathrm{Hz}$), and we specifically targeted signals shorter than $\ensuremath{\simeq}150\text{ }\text{ }\mathrm{ms}$. Our search algorithm looks for excess correlated power between the two interferometers and thus makes minimal assumptions about the gravitational waveform. We observed no candidates with gravitational-wave signal strength larger than a predetermined threshold. We report frequency-dependent upper limits on the strength of the gravitational waves associated with GRB030329. Near the most sensitive frequency region, around $\ensuremath{\simeq}250\text{ }\text{ }\mathrm{Hz}$, our root-sum-square (RSS) gravitational-wave strain sensitivity for optimally polarized bursts was better than ${h}_{\mathrm{RSS}}\ensuremath{\simeq}6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}21}\text{ }\text{ }{\mathrm{Hz}}^{\ensuremath{-}1/2}$. Our result is comparable to the best published results searching for association between gravitational waves and gamma ray bursts.
A novel 0.16 &#x03BC;m &#x2014; 300 V SOIBCD for ultrasound medical applications (2011)

The development of a new 0.16 μm SOIBCD technology integrating components with breakdown voltage higher than 300 V is here described. Process integration and mechanical stress due to buried oxide and lateral dielectric isolation was investigated with TCAD simulations, morphological analysis and Raman spectroscopy measurements. Component portfolio was derived from existing junction isolated (JI) 0.16 μm technologies and expanded with high voltage MOS. Stress induced by the full dielectric isolation is far from critical values. Breakdown voltages over 350 V were measured.
Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer (2019)

The therapy resistance of pancreatic cancer is associated with the loss of gap junction intercellular communication and connexin 43 expression. The broccoli isothiocyanate sulforaphane restored these features and therapy sensitivity. We investigated whether microRNA signaling is involved. Established cell lines and a patient tissue array (n = 96) were evaluated by miRNA and gene array, bioinformatics, expression studies, in situ hybridization and immunohistochemistry. Sulforaphane inhibited the expression of our top candidate miR30a-3p. Upon transfection of miR30a-3p inhibitors, the gemcitabine bystander effect, Cx43 expression and intercellular communication increased, whereas miR30a-3p mimics inhibited the luciferase activity of a Cx43 3'-UTR construct. miR30a-3p-overexpressing tumor xenografts had a decreased tumor volume and increased gemcitabine sensitivity. In patient tissues, a higher expression of miR30a-3p and a lower expression of Cx43 correlated with malignancy. These findings provide new knowledge and suggest sulforaphane as cotreatment for pancreatic cancer.
Localization in Wireless Networks: Foundations and Applications (2012)

In a computational tour-de-force, this volume wipes away a host of problems related to location discovery in wireless ad-hoc sensor networks. WASNs have recognized potential in many applications that are location-dependent, yet are heavily constrained by factors such as cost and energy consumption. Their ad-hoc nature, with direct rather than mediated connections between a network of wireless devices, adds another layer of difficulty. Basing this work entirely on data-driven, coordinated algorithms, the authors aim is to present location discovery techniques that are highly accurateand which fit user criteria. The research deploys nonparametric statistical methods and relies on the concept of joint probability to construct error (including location error) models and environmental field models. It also addresses system issues such as the broadcast and scheduling of the beacon. Reporting an impressive accuracy gain of almost 17 percent, and organized in a clear, sequential manner, this book represents a stride forward in wireless localization.
Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease (2008)

Novel therapies to target lung inflammation are predicted to improve the lives of people with cystic fibrosis (CF) but specific antiinflammatory targets have not been identified. The goal of this study was to establish whether TLR5 signaling is the key molecular pathway mediating lung inflammation in CF, and to determine whether strategies to inhibit TLR5 can reduce the damaging inflammatory response. The innate immune responses were analyzed in both airway epithelial cells and primary PBMCs from CF patients and matched controls. Additionally, 151 clinical isolates of Pseudomonas aeruginosa from CF patients were assessed for motility and capacity to activate TLR5. Blood and airway cells from CF patients produced significantly more proinflammatory cytokine than did control cells following exposure to the CF pathogens P. aeruginosa and Burkholderia cepacia complex (p < 0.001). Stimulation with pure TLR ligands demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF. Using complementary approaches involving both neutralizing Ab targeting TLR5 and flagellin-deficient bacteria, we established that inhibition of TLR5 abolished the damaging inflammatory response generated by CF airway cells following exposure to P. aeruginosa (p < 0.01). The potential therapeutic value of TLR5 inhibition was further supported by our demonstration that 75% of clinical isolates of P. aeruginosa retained TLR5 activating capacity during chronic CF lung infection. These studies identify the innate immune receptor TLR5 as a novel antiinflammatory target for reducing damaging lung inflammation in CF.