gebhart/patrepeval huggingface dataset:
Novel Supreme Drug-Eluting Stents With Early Synchronized Antiproliferative Drug Delivery to Inhibit Smooth Muscle Cell Proliferation After Drug-Eluting Stents Implantation in Coronary Artery Disease: Results of the PIONEER III Randomized Clinical Trial (2021)

Among patients with acute and chronic coronary syndromes undergoing percutaneous coronary intervention, the Supreme DES proved to be noninferior to the standard DP-EES. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03168776.
Effect of physical aging of poly(1-trimethylsilyl-1-propyne) films synthesized with TaCl5 and NbCl5 on gas permeability, fractional free volume, and positron annihilation lifetime spectroscopy parameters (2000)

The effect of physical aging on the gas permeability, fractional free volume (FFV), and positron annihilation lifetime spectroscopy (PALS) parameters of dense, isotropic poly(1-trimethylsilyl-1-propyne) (PTMSP) films synthesized with TaCl5 and NbCl5 was characterized. As-cast films were soaked in methanol until an equilibrium amount of methanol was absorbed by the polymer. When the films were removed from methanol, film thickness initially decreased rapidly and was almost constant after 70 h in air for both catalysts. This timescale was much longer than the timescale for complete methanol desorption (ca. 5 h). From the film-thickness data, the reduction in FFV with time was estimated. For samples prepared with either catalyst, the kinetics of FFV reduction were well-described by a simple model based on the notion either that free-volume elements diffuse to the surface of the polymer film and are subsequently eliminated from the sample or that lattice contraction controls polymer densification. Methane permeability decreased rapidly during the first 70 h, which was the same timescale for the thickness change. The decrease in methane permeability was smaller in films prepared with NbCl5 than with TaCl5. The logarithm of methane permeability decreased linearly as reciprocal FFV increased, in accordance with free-volume theory. The PALS results indicate that the concentration of larger free-volume elements (as indicated by the intensity I4) decreased with aging time and that the other PALS parameters were not strongly influenced by aging. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 1222–1239, 2000
Influence of Roller Shape on Deformation Behavior in Roll Bending of Structural Channels (2014)

Roll bending is a useful technology for manufacturing a wide variety of products in small quantities. However, the roll bending of structural channels, which have a complicated sectional shape, causes irregular deformation. On the other hand, there are fewer reports on the bending of structural channels compared to those on the roll bending of sheet-metals. The purpose of this study is to clarify the deformation behavior in the roll bending of structural channels. The present paper reports on the results from a finite element analysis of the effects of the roller shape on the deformation behavior in the roll bending of structural channels.
Production Flow Analysis through Environmental Value Stream Mapping: A Case Study of Cover Glass Manufacturing Facility (2017)

Due to the proliferation of smartphones and tablets, the touchscreen display market is expected to show a remarkable growing rate in the coming years. The large amount of profits come along with energy consumption and waste generation. Previous facility planning studies aimed to help decision makers arrive at an optimal solution in terms of cost and productivity. Given finite resources, facility planning should not only focus on cost reduction and productivity improvement, but also environmental impacts. This paper studies the application of environmental value steam map (E-VSM) in a cover glass production facility. Manufacturing data were collected from a cover glass manufacturer in China during December 2015. The purpose of this study is to evaluate the performance of the current facility design using E-VSM method, and present several strategies to reduce the energy consumption and production costs. Furthermore, a case study of cover glass manufacturing facility is presented to show that the implementation of environmentally lean strategies resulted in the reduction of both the production costs and emissions.
Dual-Band 4-Port H-DGS Based Textile MIMO Antenna Design Using Genetics Algorithms for Wearable Application (2022)

This work proposes a novel standard approach and mathematical model dedicated to the determination of the exact position of Defected Ground Structures (DGS) in terms of targeted frequencies for multiband antenna design. We investigate an approach for the first time based on Genetics Algorithms (GA) to optimize the H-DGS position for the design of a dual band MIMO antenna based on textile materials for wearable WiFi 6E application. The developed 4-port MIMO antenna operate at 3.7 and 6 GHz (WiFi 6E applications) with a realized gain and efficiency of about 3.5 dB and >80% at both frequencies, respectively.
ChemInform Abstract: Titanium‐Induced Synthesis of Furans and Indoles. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antibacterial Efficacy of Inhalable Antibiotic-Encapsulated Biodegradable Polymeric Nanoparticles Against <I>E. coli</I> Biofilm Cells (2010)

Biofilm is a sessile community of bacterial cells enclosed by a self-secreted extracellular polymeric matrix that exhibit a high recalcitrance towards antibiotics. Inhaled antibiotic nanoparticles with a sustained release capability have emerged as one of the most promising anti-biofilm formulations in the fight against respiratory biofilm infections attributed to their ability to penetrate the biofilm sputum. The present work examines the antibacterial efficacies and physical characteristics of different antibiotic-loaded polymeric nanoparticle formulations. PLGA and PCL nanoparticles prepared by an emulsification-solvent-evaporation method are used as the antibiotic carrier nanoparticles. Fluoroquinolone antibiotics (i.e., ciprofloxacin and levofloxacin) are selected as the antibiotic models due to their proven effectiveness against dormant bacterial cells and their ability to penetrate the biofilm matrix. The antibacterial efficacy against E. coli biofilm cells is examined in a time-kill study in which the effects of biofilm age, antibiotic exposure history, and drug removal are taken into account. Ciprofloxacin-loaded PLGA nanoparticles are identified as the most ideal formulation due to their high drug encapsulation efficiency, high antibacterial efficacy at a low dose against biofilm cells and biofilm-derived planktonic cells of E. coli. Moreover, the nanoparticulate suspension can be transformed into micro-scale dry-powder aerosols having aerodynamic characteristics ideal for inhaled delivery.
Nanoporous Aluminosilicate-Mediated Synthesis of Ethers by a Dehydrative Etherification Approach (2014)

High aluminum containing nanoporous aluminosilicate materials, produced by an evaporation-induced self-assembly process, efficiently catalyze the formation of unsymmetrical ethers by a dehydrative etherification reaction in high isolated yields. By carrying out the reaction under dilute conditions, the quantities of reagents can be reduced to near stoichiometric quantities.
Analysis and Control of Grid-Tied Quad-PV LLC Converter with MPPT (2020)

This paper proposes a multi input DC-DC converter that integrates four photovoltaics (PV) panels that is typically followed by a second stage of grid-tied inverter. This topology uses single LLC resonant tank to supply the output using four half-bridge converters. Maximum power point tracking (MPPT) algorithm for all four PV module is designed using four degrees of freedom. The switching frequency and three phase shifts ensures the accurate pulse width modulation (PWM) for all switches while achieving zero-voltage switching (ZVS) across all the switches for a wide input range and load variations. The dc link voltage is maintained at 300V by using outer voltage loop of the inverter controller. To reduce the harmonic distortion in injected current, a phase locked loop (PLL) with proportional resonant (PR) based controller is developed to regulate the power with single phase grid. Finally, a 1.2kW quad-PV model has been simulated and the gain equation is derived for the proposed model. The simulation results ensure that the proposed converter with closed loop control successfully agree with the derived mathematical model.
Optical imaging of RNAi-mediated silencing of cancer (2008)

RNAi has rapidly become a powerful tool for drug target discovery and validation in an <i>in vitro</i> culture system and, consequently, interest is rapidly growing for extension of its application to <i>in vivo</i> systems, such as animal disease models and human therapeutics. Cancer is one obvious application for RNAi therapeutics, because abnormal gene expression is thought to contribute to the pathogenesis and maintenance of the malignant phenotype of cancer and thereby many oncogenes and cell-signaling molecules present enticing drug target possibilities. RNAi, potent and specific, could silence tumor-related genes and would appear to be a rational approach to inhibit tumor growth. In subsequent <i>in vivo</i> studies, the appropriate cancer model must be developed for an evaluation of siRNA effects on tumors. How to evaluate the effect of siRNA in an <i>in vivo</i> therapeutic model is also important. Accelerating the analyses of these models and improving their predictive value through whole animal imaging methods, which provide cancer inhibition in real time and are sensitive to subtle changes, are crucial for rapid advancement of these approaches. Bioluminescent imaging is one of these optically based imaging methods that enable rapid <i>in vivo</i> analyses of a variety of cellular and molecular events with extreme sensitivity.
Supplementary Figure 2 from Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer (2023)

&lt;p&gt;Supplementary Figure 2 - Patient characteristics in 6 cohorts analysed&lt;/p&gt;
Load Balancing and Handover Optimization in Multi-band Networks using Deep Reinforcement Learning (2021)

Cellular networks continue to trend rapidly towards more bands and carrier frequencies, along with higher base station density, requiring complex decisions to be made when associating a mobile user with a band and cell. This paper develops a novel approach to optimizing frequency band and cell selection while taking into account user mobility and handovers. This is a complex problem because of the uncertain link failure events, handover related overheads, and the significant difference in the propagation characteristics between different frequency bands. The network dynamics due to user mobility are modeled as a Markov decision process, and we develop a recurrent Q-learning framework to exploit the relationship between user trajectories and the history of SINR measurements. The effective cell boundaries are therefore based on user trajectories and velocities rather than just position and signal strength. Detailed system-level simulations show that the proposed learning-based approach improves the throughput of the edge users by 54% and the median throughput by 34% compared to traditional SINR-based association and achieves a superior rate/coverage tradeoff (quantified as sum-log-rate) compared to SINR or signal-strength-based associations.
Copper Release Kinetics and Ageing of Insulation Paper in Oil-Immersed Transformers (2015)

The paper provides a general overview of chemical processes leading to the degradation of oil-paper insulation in oil-immersed electrical current transformers. Previous knowledge available in literature is complemented by new results placing a specific emphasis on the physicochemical factors which affect the copper release in the insulation oil and the oil oxidation kinetics. It is demonstrated that various ageing processes interact with each other, with one or another process dominating under specific conditions. Comprehensive but disjoint studies focusing on separate sub-processes may produce rather misleading results, and occasionally, lie behind rather irrelevant quality demands imposed on the insulating liquids.
StylePTB: A Compositional Benchmark for Fine-grained Controllable Text\n Style Transfer (2021)

Text style transfer aims to controllably generate text with targeted\nstylistic changes while maintaining core meaning from the source sentence\nconstant. Many of the existing style transfer benchmarks primarily focus on\nindividual high-level semantic changes (e.g. positive to negative), which\nenable controllability at a high level but do not offer fine-grained control\ninvolving sentence structure, emphasis, and content of the sentence. In this\npaper, we introduce a large-scale benchmark, StylePTB, with (1) paired\nsentences undergoing 21 fine-grained stylistic changes spanning atomic lexical,\nsyntactic, semantic, and thematic transfers of text, as well as (2)\ncompositions of multiple transfers which allow modeling of fine-grained\nstylistic changes as building blocks for more complex, high-level transfers. By\nbenchmarking existing methods on StylePTB, we find that they struggle to model\nfine-grained changes and have an even more difficult time composing multiple\nstyles. As a result, StylePTB brings novel challenges that we hope will\nencourage future research in controllable text style transfer, compositional\nmodels, and learning disentangled representations. Solving these challenges\nwould present important steps towards controllable text generation.\n
New chromophores containing sulfonamide, sulfonate, or sulfoximide groups for second harmonic generation (1993)

Efficient blue light generation by SHG for use in optical storage etc. requires materials that display not only a large nonlinear response and but also optical transparency at the wavelengths of both the laser and the blue light. New chromophores containing sulfonamide, sulfonate, or sulfoximide groups are described that come nearer to this ideal. The optical transparency of electron‐donor and electron‐acceptor substituted conjugated π systems studied previously, which was found to be poor owing to a low‐lying charge‐transfer absorption, is shown to improve when the acceptor group is sulfonamide or sulfonate ester.
ChemInform Abstract: Six‐Membered Ring Systems: Triazines, Tetrazines and Fused Ring Polyaza Systems (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer (2005)

Although strides have been made in the diagnosis and treatment of cancer in the past few decades, advanced, metastatic cancer remains extremely difficult to treat. Obviously, a major hurdle in improving survival is the treatment or prevention of metastatic disease, either to eliminate it completely or to contain it like other chronic diseases. To reach the metastatic stage, the cancer cells undergo many and various changes in the usual regulatory mechanisms governing cellular proliferation and apoptosis, resulting in great heterogeneity. Therein lies the challenge in developing appropriate and effective combination therapies for metastatic disease that utilize multiple mechanisms to overcome resistance to cell death. In this chapter, the relatively new cytotoxic taxane docetaxel will be discussed in the context of its current role in treating metastatic cancer and its future role in combination with novel, molecularly targeted chemotherapeutic agents.
Implementing non protected paths using SPRING (2017)

Segment Routing (SR) leverages the source routing paradigm. A node can
steer a packet on a specific path by prepending the packet with an SR
header. In the framework of traffic-engineering use cases, a customer
may request its service provider to implement some non protected
paths. This means that in case of a failure within the network, fast-
reroute (or similar) techniques should not be activated for those
paths. This document analyzes the different options to implement a non
protected path with Segment Routing and in a future release will
provide a recommandation on the best option.
Comparison of RF body coils for MRI at 3  T: a simulation study using parallel transmission on various anatomical targets (2015)

The performance of multichannel transmit coil layouts and parallel transmission (pTx) RF pulse design was evaluated with respect to transmit B1 (B1 (+)) homogeneity and specific absorption rate (SAR) at 3 T for a whole body coil. Five specific coils were modeled and compared: a 32-rung birdcage body coil (driven either in a fixed quadrature mode or a two-channel transmit mode), two single-ring stripline arrays (with either 8 or 16 elements), and two multi-ring stripline arrays (with two or three identical rings, stacked in the z axis and each comprising eight azimuthally distributed elements). Three anatomical targets were considered, each defined by a 3D volume representative of a meaningful region of interest (ROI) in routine clinical applications. For a given anatomical target, global or local SAR controlled pTx pulses were designed to homogenize RF excitation within the ROI. At the B1 (+) homogeneity achieved by the quadrature driven birdcage design, pTx pulses with multichannel transmit coils achieved up to about eightfold reduction in local and global SAR. When used for imaging head and cervical spine or imaging thoracic spine, the double-ring array outperformed all coils, including the single-ring arrays. While the advantage of the double-ring array became much less pronounced for pelvic imaging, with a substantially larger ROI, the pTx approach still provided significant gains over the quadrature birdcage coil. For all design scenarios, using the three-ring array did not necessarily improve the RF performance. Our results suggest that pTx pulses with multichannel transmit coils can reduce local and global SAR substantially for body coils while attaining improved B1 (+) homogeneity, particularly for a "z-stacked" double-ring design with coil elements arranged on two transaxial rings.
A study of the conformational and pharmacophoric requirements of ligands of the cannabinergic system using NMR and computer modeling (2006)

The interaction of different ligands with various components of the cannabinergic system was studied to determine the role of the ligands' conformations. Such ligands can modulate many physiological and psychological responses controlled by that system. Therefore knowledge of their conformations may aid in developing potent cannabinergic drugs. Three objectives were achieved. ^ First, NOESY and molecular dynamics were performed, and a method based upon relaxation rate calculations was developed, to determine the arachidonyl backbone conformations of six anandamide analogs in isotropic bicelles ( q=1.0, 3% w/v, and 10:1 [DMPC]:[ligand]) and DMSO. No long range NOEs were observed, suggesting extended conformations for the backbones. In bicelles, anandamide preferred an inverse-L shape while R-methyl anandamide preferred either a fully extended or compact-C shape. Additionally, analysis of measured coupling constants revealed a possible intramolecular hydrogen bond between the carbonyl oxygen and the hydroxy proton of those ligands in DMSO. NOESY spectra analysis, however, suggests this bond occurs infrequently in bicelles. Finally, experiments with chemical shift reagents showed that the analogs orient within the bicelle with their head groups at the aqueous interface and their alkyl tails within the interior. ^ Second, quantum mechanical calculations were employed to explain differences in kinetic parameters (Vmax, Km) among six anandamide analogs with different head group structures when hydrolyzed by fatty acid amide hydrolase. For all analogs, head group conformations with a dihedral angle (C1-N-C1'-C2') of -140° yielded transition state energies that correlated with the Vmax values. The binding energies, however, did not correlate with the Km values. Since the active site is buried within the enzyme, solvation energies, strain energies, and head group surface areas were needed to explain the mechanism of ligand binding. ^ Finally, cannabinoid receptor docking was used to explain differences in binding affinity among various classical cannabinoids. Calculated receptor volume maps revealed the ideal sizes needed by different ligand moieties for optimal binding. Surprisingly, docking showed that although large ligand moieties may be accommodated by the receptors instead of clashing with nearby residues, unfavorable interactions may result between the binding pocket and other areas of the ligand normally well accommodated by the receptor. ^
Sizing Optimization with Thermal and Electrical Matching of a Thermogenerator placed on the Human Body (2011)

International audience
Egalitarianism among Bubbles in Porous Media: An Ostwald Ripening Derived Anticoarsening Phenomenon (2017)

We show that smaller gas bubbles grow at the expense of larger bubbles and all bubbles approach the same surface curvature after long times in porous media. This anticoarsening effect is contrary to typical Ostwald ripening and leads to uniformly sized bubbles in a homogeneous medium. Evolution dynamics of bubble populations were measured, and mathematical models were developed that fit the experimental data well. Ostwald ripening is shown to be the driving mechanism in this anticoarsening phenomenon; however, the relationship between surface curvature and bubble size determined by the pore-throat geometric confinement reverses the ripening direction.
Implant Survivorship and Complication Rates after Total Knee Arthroplasty with a Third-generation Cemented System (2005)

Therapeutic study, Level III-2 (retrospective cohort study).
Do we need dedicated heart failure with preserved ejection fraction clinics? (2023)

Impairments in exercise reserve across multiple organ systems in prior select HFpEF samples vs. Verwerft et al. (dyspnoea with high HFpEF diagnostic scores). Abbreviations: CO, cardiac output; HFpEF, heart failure with preserved ejection fraction; HR, heart rate; PCWP, pulmonary capillary wedge pressure; peak VO2, peak oxygen uptake; PH, pulmonary hypertension; SVI, stroke volume index; VA, ventriculo-arterial; VE/VCO2, minute ventilation/carbon dioxide production.
Fluorine Passivation of Metal Alloy Surface with Volatile Reaction Enhanced Mechanism (1992)

Volatile reaction enhanced fluoridation of metal surface is shown to produce excellent passivated metal surfaces exhibiting complete resistance to corrosive gases and reactive gas plasma bombardment. Fluoridation is carried out on Ni‐P plated films on aluminum where the films contain 3.6–12 weight percent (w/o) phosphorus. Composition of the fluoride film on a Ni‐P surface is confirmed to be where phosphorus is converted to , and is evaporated from the film during fluoridation, i.e., reaction of Ni‐P with fluorine gas. An activation energy of the fluoridation of Ni‐P film decreases with a certain amount of phosphorus concentration. Thus, this fluoridation is referred to by us as volatile reaction enhanced fluoridation. The films are demonstrated to exhibit very strong resistance to corrosive gases and reactive gas plasma bombardment.