gebhart/patrepeval huggingface dataset:
Synthesis of Novel Carboxyl Porphyrins and Their Iron Complexes: 5,10,15,20-Tetra[a,a,a,a-o-(2,2-Dimethyl-w-carboxylalkanamido)phenyl]porphinato Iron Complexes (1984)

a -Novel porphyrin derivatives having 2.2-dimethyl-w-carboxylalkyl chains as amphiphilic moieties and their iron complexes are synthesized.The typical compound is bromo-5,10,15,20-tetra[a,a,a,u-o- (2,2-dimethyl-12-carboxyldodecanamido)phenyl]porphinato iron(m ).The lipophilic-liophilic balance can be controlled by changing the alkyl chain length.Polyfunctionalized tetraphenylporphyrinr are of interest from the standpoint of preparing the models of natural hernoproteins.l-l0The liposome-bound metalloporphyrins have been reported as a model photosensitizer for chlorophylls11'12 and of membrane-solubilized hemoproteins.13-16 Accordingly an amphiphilic property is needed for a porphyrin to be taken better into the model membranes (liposomes).The control of the lipophilic-liophilic balance of a model is expected to be the key to get better model systems.In the present report, we wish to comnunicate the synthesis of a series of novel amphiphilic porphyrins by introducing four w-carboxylalkyl groups per porphyrin and the control of tlie lipcphilic-liophilic balance by changing the length of alkyl chains.The carboxyl group-bearing porphyrins and their iron(m) complexes synthesized in the present work are schematically represented in Figure 1 and sumnarized in Table I.These compounds are 5,10,15,2O-tetra[a,a,u,a-o-(2.2-dimethyl-w-carboxylalkanamido)phenyl]porphinesand the 19.
Direct recognition by αβ cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function (2005)

Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether alphabeta T cells could recognize MHC molecules independently of bound ligands, we studied human and mouse Hfe interactions with T lymphocytes. We provide formal evidence of direct cytolytic recognition of human Hfe by mouse alphabeta T cell receptors (TCR) in HLA-A*0201 transgenic mice and that this interaction results in ZAP-70 phosphorylation. Furthermore, direct recognition of mouse Hfe molecules by cytotoxic T lymphocytes (CTLs) was demonstrated in DBA/2 Hfe knockout mice. These CTLs express predominantly two T cell antigen receptor alpha variable gene segments (AV6.1 and AV6.6). Interestingly, in wild-type mice we identified a subset of CD8+ T cells positively selected by Hfe that expresses the AV6.1/AV6.6 gene segments. T cell antigen receptor recognition of MHC molecules independently of bound ligand has potential general implications in alloreactivity and identifies in the Hfe case a cognitive link supporting the concept that the immune system could be involved in the control of iron metabolism.
The rrs (16S)-rrl (23S) ribosomal intergenic spacer region as a target for the detection of Haemophilus ducreyi by a heminested-PCR assay (1998)

The intergenic spacer region between the rrs and rrl ribosomal RNA genes of Haemophilus ducreyi was analysed and the DNA sequence was used for the selection of specific PCR primers. A highly sensitive and specific heminested-PCR assay for the identification of H. ducreyi was developed. The assay showed a sensitivity of 96% on genital ulcer specimens from patients with clinically diagnosed chancroid, compared with a sensitivity of 56% for culture methods. These results indicate that this PCR assay has the potential to become an accurate and easy reference method for the detection of H. ducreyi.
Surfactant Replacement Therapy for Meconium Aspiration Syndrome (1996)

Surfactant replacement therapy, if started within 6 hours after birth, improves oxygenation and reduces the incidence of air leaks, severity of pulmonary morbidity, and hospitalization time of term infants with MAS.
Experimental and numerical analysis of conductive ternary polymer blend composites (2017)

ABSTRACT Experimental and theoretical analysis of the phase morphology and electrical conductivity of a carbon black (CB)‐filled polypropylene /poly(methyl methacrylate) /ethylene acrylic acid copolymer ternary system were compared. The Cahn‐Hilliard theory was used to model and predict the phase morphology and electrical conductivity as a function of the constituents' characteristics of the ternary system. A method for generating statistically representative microstructures of a co‐continuous ternary polymer system and a numerical method for calculating the resultant electrical conductivity of these ternary polymer systems are presented. Excellent agreement between numerically calculated and experimentally measured results was observed. The developed analytical and numerical models were able to successfully predict the electrical percolation threshold with that of ternary polymer composites containing CB as a conductive medium with minimal experimental input. The combination of experimental and numerical results presented suggests the optimization of the conductive minor phase includes having a conductivity beyond the critical percolation threshold, is at least three orders of magnitude greater than either of the two nonconductive phases, and has a lower viscosity than the other two major phases in order to maximize the phase separation kinetics. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44749.
The Active Tube Clearance System a Novel Bedside Chest-Tube Clearance Device (2010)

: By maintaining chest tube patency, chest tube drainage can be performed more safely, and this apparatus may possibly lead to the use of smaller chest tubes and less invasive insertion techniques.
Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques (2015)

The induction of a balanced immune response targeting the major structural proteins, Gag and Env of HIV, is important for the development of an efficacious vaccine. The use of DNA plasmids expressing different antigens offers the opportunity to test in a controlled manner the influence of different vaccine components on the magnitude and distribution of the vaccine-induced cellular and humoral immune responses. Here, we show that increasing amounts of env DNA results in greatly enhanced Env antibody titers without significantly affecting the levels of anti-Env cellular immune responses. Co-immunization with Env protein further increased antibody levels, indicating that vaccination with DNA only is not sufficient for eliciting maximal humoral responses against Env. In contrast, under high env:gag DNA plasmid ratio, the development of Gag cellular responses was significantly reduced by either SIV or HIV Env, whereas Gag humoral responses were not affected. Our data indicate that a balanced ratio of the 2 key HIV/SIV vaccine components, Gag and Env, is important to avoid immunological interference and to achieve both maximal humoral responses against Env to prevent virus acquisition and maximal cytotoxic T cell responses against Gag to prevent virus spread.
A Numerical Study of a Single Unsteady Laminar Slot Jet in a Confined Structure (2013)

With the inherit advantages of air cooling, jet impingement can produce a factor of two or higher heat transfer than conventional fan flow over bodies. Therefore, impinging jets can solve a number of electronics thermal issues. Those jets produce complex flow and thermal structures leading to non-uniform and non-monotonic profiles on target surfaces. A numerical study is performed to investigate the flow and heat transfer characteristics of an unsteady laminar impinging jet emanated from a single high-aspect ratio rectangular (slot) nozzle in a confined arrangement. The spacing between the target plate and the nozzle is such that the jet would still be in its potential core length as it was in a free axial jet. Following the initial transients, flow and heat transfer parameters still vary considerably in time that the instantaneous and time-averaged values of surface profiles are not identical. Instantaneous surface pressure distributions exhibit that the stagnation point translates periodically around the initial jet-symmetry line and the surface profiles demonstrate off-center (non-stagnation point) peaks.
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolution (2021)

Limited knowledge exists on immune markers associated with disease severity or recovery in patients with coronavirus disease 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire in patients with acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, antibody binding, and affinity maturation in "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide and receptor binding domain (RBD) in patients with mild COVID-19 who recovered early compared with "fatal" COVID-19 patients. In patients with severe COVID-19, high-titer IgA were observed, primarily against RBD, especially in patients who succumbed to SARS-CoV-2 infection. The patients with mild COVID-19 showed marked increase in antibody affinity maturation to prefusion SARS-CoV-2 spike that associated with faster recovery from COVID-19. This study revealed antibody markers associated with disease severity and resolution of clinical disease that could inform development and evaluation of effective immune-based countermeasures against COVID-19.
Bulk Passivation of Defects in Multi-Crystalline Silicon Solar Cells by a-SiN<sub>x</sub>:H Layers (2009)

In this work the impact of hydrogenation from hydrogen-rich amorphous silicon nitride (a-SiNx:H) on dislocations and grain boundaries in multi-crystalline silicon (mc-Si) solar cells is presented. Layers are deposited by means of plasma enhanced chemical vapor deposition (PECVD). Electrical bulk passivation is provided during thermal annealing, in which hydrogen diffuses from a-SiNx:H. The passivation effect is discussed in terms of recombination centers and non-recombinative charge traps reduction as well as in terms of local short circuit current improvement in specially manufactured solar cells.
(+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity (1995)

The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor antagonist. The compound was synthesized in seven steps starting from indoline and isonicotinic acid chloride. The key step is a photocyclization of the indolinyl tetrahydropyridinocarbamic acid ethyl ester 4 to the cis-octahydroindolo[1, 7-bc][2,6]naphthyridinecarbamic acid ethyl ester 5. The synthesis was accomplished by reduction with aluminum hydride and racemic resolution. The indolonaphthyridine 8 exerted the binding profile of a selective 5-HT2C receptor ligand (pKD 7.8) and behaved as an antagonist on the 5-HT-induced accumulation of inositol phosphates in pig choroid plexus cells (pKB 7.13). Compound 8 dose-dependently inhibited the ACTH response to MK-212 in rats and the MK-212-induced hypophagic effect with an ID50 value of 0.3 mg/kg sc. Compound 8 acted as a 5-HT2B receptor antagonist at the rat stomach fundus with a pKB value of 7.34.
Evaluation of volume imaging with the HEAD PENN-PET scanner (2002)

A volume-imaging PET scanner for brain, animal, and pediatric imaging has been designed and built to achieve high performance, specifically in sensitivity and spatial resolution. The scanner is unique in its use of a single annular crystal of NaI(Tl), which allows a 30 cm diameter patient port and an axial field-of-view of 25.6 cm with a maximum axial acceptance angle a of /spl plusmn/26/spl deg/. By using a narrow photopeak energy window, this leads to high sensitivity with relatively low scatter and randoms. Image resolution is 3.5 mm in both the transverse and axial directions. Images are reconstructed with 128 slices, and are presented for phantom and patient studies (FDG) with both the multi-slice rebinning and the 3D-reprojection algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Leadership and Management (1996)

The prelims comprise: Leadership theories What is leadership and management in R&D? Leadership and structure The matrix challenges Characteristics of the good leader
Performance comparison of single carrier and OFDM in coherent optical long-haul communication systems (2011)

We investigate the nonlinear tolerance of coherent detected 50 Gbit/s dual-polarization binary-phase-shift-keying (DP-BPSK), 100 Gbit/s dual-polarization quaternary-phase-shift-keying (DP-QPSK), and 200 Gbit/s dual-polarization 16-ary quadrature amplitude modulation (DP-16-QAM) for single carrier with pulse shaping and orthogonal frequency division multiplexing (OFDM). The performance of these systems is compared and tested in two different scenarios: dispersion managed and unmanaged links. The results show that employing return-to-zero with 50 % of duty cycle (RZ50) as pulse shaping has a superior performance, especially in dispersion unmanaged links.
629: Proteomic Identification of Interleukin-2 Therapy Responders in Metastatic Renal Cell Cancer (2005)

You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 8:00 am - 12:00 pm1 Apr 2005629: Proteomic Identification of Interleukin-2 Therapy Responders in Metastatic Renal Cell Cancer Jon Jones, Dimitrios Spentzos, Hasan Otu, Manuel Aivado, Shakirahmed Kolia, Jeffrey Paullus, Arie S. Belldegrun, Robert A. Figlin, Towia A. Libermann, and Allan J. Pantuck Jon JonesJon Jones More articles by this author , Dimitrios SpentzosDimitrios Spentzos More articles by this author , Hasan OtuHasan Otu More articles by this author , Manuel AivadoManuel Aivado More articles by this author , Shakirahmed KoliaShakirahmed Kolia More articles by this author , Jeffrey PaullusJeffrey Paullus More articles by this author , Arie S. BelldegrunArie S. Belldegrun More articles by this author , Robert A. FiglinRobert A. Figlin More articles by this author , Towia A. LibermannTowia A. Libermann More articles by this author , and Allan J. PantuckAllan J. Pantuck More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34869-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "629: Proteomic Identification of Interleukin-2 Therapy Responders in Metastatic Renal Cell Cancer." The Journal of Urology, 173(4S), pp. 171–172 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 171-172 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jon Jones More articles by this author Dimitrios Spentzos More articles by this author Hasan Otu More articles by this author Manuel Aivado More articles by this author Shakirahmed Kolia More articles by this author Jeffrey Paullus More articles by this author Arie S. Belldegrun More articles by this author Robert A. Figlin More articles by this author Towia A. Libermann More articles by this author Allan J. Pantuck More articles by this author Expand All Advertisement PDF downloadLoading ...
Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets (2015)

The blood fluke Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease (NTD) that affects more than 110 million people. Treating this disease by targeted or mass administration with a single chemical, praziquantel, carries the risk that drug resistance will develop in this pathogen. Therefore, there is an imperative to search for new drug targets in S. haematobium and other schistosomes. In this regard, protein kinases have potential, given their essential roles in biological processes and as targets for drugs already approved by the US Food and Drug Administration (FDA) for use in humans. In this context, we defined here the kinome of S. haematobium using a refined bioinformatic pipeline. We classified, curated and annotated predicted kinases, and assessed the developmental transcription profiles of kinase genes. Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind to them using an integrated bioinformatic pipeline. Most kinases of S. haematobium are very similar to those of its congener, S. mansoni, offering the prospect of designing chemicals that kill both species. Overall, this study provides a global insight into the kinome of S. haematobium and should assist the repurposing or discovery of drugs against schistosomiasis.
γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection (2019)

Cerebral malaria (CM) is a major cause of death due to <i>Plasmodium</i> infection. Both parasite and host factors contribute to the onset of CM, but the precise cellular and molecular mechanisms that contribute to its pathogenesis remain poorly characterized. Unlike conventional αβ-T cells, previous studies on murine γδ-T cells failed to identify a nonredundant role for this T cell subset in experimental cerebral malaria (ECM). Here we show that mice lacking γδ-T cells are resistant to ECM when infected with <i>Plasmodium berghei</i> ANKA sporozoites, the liver-infective form of the parasite and the natural route of infection, in contrast with their susceptible phenotype if challenged with <i>P. berghei</i> ANKA-infected red blood cells that bypass the liver stage of infection. Strikingly, the presence of γδ-T cells enhanced the expression of <i>Plasmodium</i> immunogenic factors and exacerbated subsequent systemic and brain-infiltrating inflammatory αβ-T cell responses. These phenomena were dependent on the proinflammatory cytokine IFN-γ, which was required during liver stage for modulation of the parasite transcriptome, as well as for downstream immune-mediated pathology. Our work reveals an unanticipated critical role of γδ-T cells in the development of ECM upon <i>Plasmodium</i> liver-stage infection.
Supplemental Figure Legends from STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells (2023)

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<title>An extension of the reduced resolution update mode to complexity constrained spatial scalable video coding</title> (2005)

It is highly desirable for many broadcast video applications to be able to provide support for many diverse user devices, such as devices supporting different resolutions, without incurring the bitrate penalty of simulcast encoding. On the other hand, video decoding is a very complex operation, while the complexity is very dependent on the resolution of the coded video. Low power portable devices typically have very strict complexity restrictions and reduced-resolution displays. For such environments total bitrate efficiency of combined layers is an important requirement, but the bitrate efficiency of a lower layer individually, although desired, is not a requirement. In this paper, we propose a complexity constrained scalable system, based on the Reduced Resolution Update mode that enables low decoding complexity, while achieving better Rate-Distortion performance than an equivalent simulcast based system. Our system is targeted on broadcast environment with some terminals having very limited computational and power resources.
Mechanism to support generic collective communication across a variety of programming models (2023)

A system and method for supporting collective communications on a plurality of processors that use different parallel programming paradigms, in one aspect, may comprise a schedule defining one or more tasks in a collective operation, an executor that executes the task, a multisend module to perform one or more data transfer functions associated with the tasks, and a connection manager that controls one or more connections and identifies an available connection. The multisend module uses the available connection in performing the one or more data transfer functions. A plurality of processors that use different parallel programming paradigms can use a common implementation of the schedule module, the executor module, the connection manager and the multisend module via a language adaptor specific to a parallel programming paradigm implemented on a processor.
Wire Delay is Not a Problem for SMT (In the Near Future) (2004)

Previous papers have shown that the slow scaling of wiredelays compared to logic delays will prevent superscalar performancefrom scaling with technology.In this paper we showthat the optimal pipeline for superscalar becomes shallowerwith technology, when wire delays are considered, tighteningprevious results that deeper pipelines perform only as well asshallower pipelines.The key reason for the lack of performancescaling is that superscalar does not have sufficient parallelismto hide the relatively-increased wire delays.However,Simultaneous Multithreading (SMT) provides the much-neededparallelism.We show that an SMT running a multiprogrammedworkload with just 4-way issue not only retains theoptimal pipeline depth over technology generations, enablingat least 43% increase in clock speed every generation, but alsoachieves the remainder of the expected speedup of two pergeneration through IPC.As wire delays become more dominantin future technologies, the number of programs needs tobe scaled modestly to maintain the scaling trends, at least tillthe near-future 50nm technology.While this result ignoresbandwidth constraints, using SMT to tolerate latency due towire delays is not that simple because SMT causes bandwidthproblems.Most of the stages of a modern out-of-order-issuepipeline employ RAM and CAM structures.Wire delays in conventional,latency-optimized RAM/CAM structures preventthem from being pipelined in a scaled manner.We show thatthis limitation prevents scaling of SMT throughput.We use bitlinescaling to allow RAM/CAM bandwidth to scale with technology.Bitline scaling enables SMT throughput to scale at therate of two per technology generation in the near future.
Nox1 is over‐expressed in human colon cancers and correlates with activating mutations in K‐Ras (2008)

The NADPH-oxidase 1 (Nox1) is a homolog of gp91phox, the catalytic subunit of the phagocyte superoxide-generating NADPH-oxidase. Nox1 is expressed in normal colon epithelial cells and in colon tumor cell lines, and overexpression in model cells has been implicated in stimulation of mitogenesis and angiogenesis and inhibition of apoptosis. This suggests that aberrant expression of Nox1 could contribute to the development of colorectal cancer. Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer. Nox1 was overexpressed compared with paired normal tissue in 57% of tumors as early as the adenoma stage, with no correlation of expression level with tumor stage. Overexpression of Nox1 mRNA correlated with Nox1 protein levels assessed by immunofluorescence and immunohistochemistry with an antibody specific for Nox1. There was a strong correlation between Nox1 mRNA level and activating mutations in codons 12 and 13 of K-Ras. Eighty percent (8/10) of tumors with codons 12 and 13 mutations had a 2-fold or more increase in Nox1 mRNA, and 70% (7/10) had a 5-fold or greater increase. Transgenic mice expressing K-Ras(G12V) in the intestinal epithelium also expressed markedly elevated Nox1 in both small and large intestine. There was no correlation between inactivating mutations in the tumor suppressor p53 and Nox1 expression. We conclude that Nox1 mRNA and protein are overexpressed in colon cancer and are strongly correlated with activating mutations in K-Ras.