gebhart/patrepeval huggingface dataset:
POSTER: An innovative storage stack addressing extreme scale platforms and Big Data applications (2014)

Current production HPC IO stack design is unlikely to offer sufficient features and performance to adequately serve extreme scale science platform requirements as well as Big Data problems. A joint effort between the US Department of Energy's Office of Advanced Simulation and Computing and Advanced Scientific Computing Research commissioned a project to develop a design and prototype for an IO stack suitable for the extreme scale environment. It will be referred to as the Fast Forward Storage and IO (FFSIO) project. This is a joint effort led by Lawrence Livermore National Laboratory, with the DOE Data Management Nexus leads Rob Ross and Gary Grider as coordinators and contract lead Mark Gary.
Novel PSK enumeration for efficient VLSI implementation of MIMO detection (2007)

The paper discusses a Novel PSK enumeration technique for VLSI implementation of K-Best MIMO detection. The detection is modeled as a closet point search problem in N x N lattice and further simplified to a breadth first tree search problem of depth N for a N x N MIMO channel. The breadth first search has been carried out using spiral searches and a predictor-extender algorithm to decode the k best points in order of their path metric. The proposed enumeration technique is tested for a 4 X 4 MIMO channel with 64-QAM modulation. VLSI implementation of the PSK enumeration cell was implemented using Synopsys synthesis tool with a 0.13μm CMOS technology and optimized to achieve an area of 764 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and power of 52.58μW.
Orthogonal Solid-Phase Peptide Synthesis (2015)

I am deeply honored to receive the Murray Goodman Scientific Excellence & Mentoring Award, and to join the distinguished company of its past recipients. It was a privilege to know Professor Goodman, whose exceptional combination of scientific innovation and mentorship offers a model we can all hope to emulate. Our theme is orthogonality, a concept I introduced to peptide chemistry during my doctoral studies with Bruce Merrifield at The Rockefeller University [1, 2], and which has been a centerpiece of my independent career on the University of Minnesota chemistry faculty.
A new controller for modular multi-level converters (2016)

Modular multi-level converters (M2LCs) are typically controlled by using a hierarchical control scheme, where at least two loops are employed to control the load currents and circulating currents. This paper presents a new model predictive controller to control an M2LC with a single controller, which controls the load currents within tight bounds and minimizes capacitor voltage variations and circulating currents. The proposed controller uses the slope of load currents trajectories to emulate long prediction horizons. When switching is required due to violation of its bounds, a switch position that yields the trajectory with the minimum slope, relative to the reference trajectory, is determined and applied to the converter. Simulated performance of a three-phase three-level 2-MVA grid connected M2LC, during both steady-state and transient conditions, is presented to validate the feasibility of the proposed scheme.
Cancellation of Bulging Effect on Mold Level in Continuous Casting: Experimental Validation (2009)

International audience
50-nm wavelength-tunable self-oscillating electro-optic frequency comb generator (2006)

A widely (>50 nm) wavelength-tunable self-oscillating electro-optic frequency comb generation using phase modulator was demonstrated. Wavelength of the oscillation was controlled by tuning asymmetric filtering. Co-injection of two lights enabled copying the comb to other wavelength
Initial experience with a new ultrasound imaging technique to measure tissue viscoelasticity (2008)

The emphasis of mammographic breast screening is to detect small invasive breast cancers at a time in their natural history when early detection and treatment will reduce significantly the risk of death.However, breast screening cannot be absolutely specific in its approach and detects a wide spectrum of breast cancer, ranging from microfocal low-grade ductal carcinoma in situ to large highgrade invasive cancer.It is well recognized that many of the lowgrade, special invasive cancers identified at screening have an excellent prognosis but may be so indolent that they would never have presented clinically or have threatened the life of the patients.It has been proposed alternatively that a proportion of these low-grade invasive tumours might, if not detected, de-differentiate over time into more aggressive, less well-differentiated tumours.Identification and removal of such cancers when they are at a low grade would avoid such progression.Detection of high-grade invasive cancers when they are small is clearly a means by which screening could reduce breast cancer mortality; for example, the Two-County Trial in Sweden has shown that histological grade 3 invasive cancers detected when <10 mm have an excellent prognosis, while it is widely recognized that large high-grade invasive cancers have a poor prognosis.In addition, the presence of vascular invasion and lymph node metastasis, which are associated with development of metastatic disease, are rare in grade 3 tumours <10 mm, grade 2 tumours <10 mm and grade 1 tumours <20 mm, indicating that detecting tumours under a certain size should be beneficial. Positron emission tomography in breast disease
Fabrication of porous aluminum by tool-traversing friction powder sintering process (2014)

Porous aluminum was fabricated by tool-traversing friction powder sintering process with the sintering and dissolution process (SDP). In this process, the starting material was a mixture of aluminum powder and sodium chloride (NaCl) as spacer particles. After the powder mixture was placed in a mold, compaction and sintering was conducted only by the traversing of a rotating tool as in friction stir welding. Namely, no external heat source was necessary for the fabrication of porous aluminum, except for the friction heat generated by the traversing of the tool. In this study, porous aluminum with porosities of 60%, 70% and 80%, and a length equal to the tool traversing length was successfully fabricated. By X-ray computed tomography (CT) and scanning electron microscope (SEM) observations of the pore distribution and shapes, it was found that fabricated porous aluminum had a uniform pore distribution with pore shapes similar to the NaCl morphology, regardless of the porosity and the position along the tool traversing direction. In a compression test, the fabricated porous aluminum was observed to exhibit ductile fracture behavior, indicating that the aluminum powder was sufficiently sintered. The fabricated porous aluminum had almost the same plateau stress regardless of the position along the tool traversing direction for each porosity.
Application of polarization microscopy for the nonstained determination of myo-lamina morphology in the rat (2004)

The remodeling of cardiac tissues has been implicated in the development of congestive heart failure. Therefore, the current emphasis in cardiovascular research is geared toward understanding the underlying processes in order to facilitate the development of better prevention and treatment regimens by improving the early detection and diagnosis of this disease. This paper focuses on the application of polarized light to address a major drawback of cardiovascular biomechanics research, which is the utilization of toxic chemicals to prepare samples for histological examination. To accomplish this without the use of toxic chemicals, a polarization microscopy imaging technique was developed and applied to a non-stained rat septum sample. This imaging technique provided sufficient enhancement of collagenous structures to determine the myo-lamina sheet angle, &#946;, without the need for caustic staining.
Multiple mutations in the variable region of the κ light chains of three monoclonal human IgM with anti-myelin-associated glycoprotein activity (1989)

Human monoclonal IgM having an antibody activity directed to myelin-associated glycoprotein have distinctive features. Amino-terminal sequence of light and heavy chains from 6 IgM kappa that we have previously studied indicated that heavy chains belong to the VHIII subgroup, whereas light chains belong to 3 different subgroups of variability (V kappa I 2, V kappa II 1, and V kappa IV 3). We report here the complete sequence of the variable domain of 3 L chains: 2 V kappa IV and 1 V kappa II subgroups. Strikingly an unusually high degree of mutations clustered in the complementarity-determining regions (CDR) 1 and CDR 3 was found and the variable regions were joined to three different JK segments. Amino acid substitutions did not yield similar sequence in the CDRs suggesting that the kappa chains had no predominant role in the unique binding activity of these IgM or alternatively they are directed against different epitopes. Data are consistent with the previously reported lack of easily demonstrated public idiotopes common to anti-myelin-associated glycoprotein IgM. The pathogenesis of these IgM autoantibodies is most likely different from that of previously studied monoclonal rheumatoid factors or cold agglutinins where a genetic restriction of L or H chains or both has been observed.
ChemInform Abstract: A NUCLEOPHILIC ETHYNYL GROUP EQUIVALENT AND ITS USE IN CONJUGATE ADDITION TO ALPHA,BETA-ENONES (1974)

Das nach bekannten Methoden aus dem trans-Äthylen (I) durch Behandlung mit n-Butyl-Li und nachfolgende Reaktion mit n-Propyläthinylkupfer dargestellte Licuprat (II) wird mit dem Enon (III) bei -78°C bis -40°C in THF-Lösung zum Keton (IV) umgesetzt.
Man-machine interfaces using image information obtained by a 32x32-pixel artificial retina chip (1997)

The image is one of the most suitable information input representations for future multimedia systems. However, it is difficult for conventional charge coupled device (CCD) systems to handle such image information, especially in high speed image processing such as motion picture processing. This is caused by the limitation of the frame rate of the CCD (1/60-1/30sec) and by the bus capacity between the CCD and the computer. To solve the problem of this transmission bottle neck, we have proposed a novel type of image sensor, an artificial retina (AR) chip, and we have demonstrated flexible and high-speed on-chip processing capabilities of the chip [1].
An efficient caching scheme for software RAID file systems in workstation clusters (2002)

A software RAID file system is defined as a system that distributes data redundantly across an array of disks attached to each of the workstations connected on a high speed network. This provides high throughput as well as higher availability. In this paper we present an efficient caching scheme for the software RAID file system. The performance of this scheme is compared to two other schemes previously proposed for conventional file systems and adapted for the software RAID file system. As in hardware RAID systems, we found small-writes to be the performance bottleneck in software RAID file systems. To tackle this problem, we logically divided the cache into two levels. By keeping old data and parity values in the second-level cache we were able to eliminate much of the extra disk reads and writes necessary for write-back of dirty blocks. Using trace driven simulations we show that the proposed scheme improves performance by at least 10% for both the hit ratio and the average system busy time.
Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair–Proficient Stage II Colon Cancer (2016)

GIV expression status predicts recurrence risk in patients with T3 pMMR stage II colon cancer. A risk model combining GIV expression and LVI status information further enhances prediction of recurrence. Further validation studies are warranted before GIV status can be routinely included in patient management algorithms. Clin Cancer Res; 22(14); 3488-98. ©2016 AACR.
Improving color characteristics of LCD (2005)

The drive for larger size, higher spatial resolution, and wider aperture LCD has shown to increase the electrical crosstalk between electrodes in the driver circuit. This crosstalk leads to additivity errors in color LCD. In this paper, the LCD color crosstalk was modeled using a capacitance coupling mode and the crosstalk effect was analyzed with micrographs captured from an imaging colorimeter. The experimental result reveals the subpixel nature of color crosstalk that whenever any two neighboring subpixels are “on” at the same time, there is crosstalk from one subpixel to another, but whenever there is one “off” subpixel between the two “on” subpixels, there is no crosstalk between the “on” subpixels. There is positive crosstalk from right to left across all three subpixels. Based on this crosstalk model, the crosstalk of a LCD was characterized and a spatial subpixel crosstalk correction algorithm was developed to improve the color performance of LCD. The correction algorithm reduced crosstalk by a factor of 16. Compared to a 3D lookup table approach, the new algorithm is easier to implement and more accurate in performance.
Establishing a Cell-Free Vibrio natriegens Expression System (2018)

The fast growing bacterium Vibrio natriegens is an emerging microbial host for biotechnology. Harnessing its productive cellular components may offer a compelling platform for rapid protein production and prototyping of metabolic pathways or genetic circuits. Here, we report the development of a V. natriegens cell-free expression system. We devised a simplified crude extract preparation protocol and achieved >260 μg/mL of superfolder GFP in a small-scale batch reaction after 3 h. Culturing conditions, including growth media and cell density, significantly affect translation kinetics and protein yield of extracts. We observed maximal protein yield at incubation temperatures of 26 or 30 °C, and show improved yield by tuning ions crucial for ribosomal stability. This work establishes an initial V. natriegens cell-free expression system, enables probing of V. natriegens biology, and will serve as a platform to accelerate metabolic engineering and synthetic biology applications.
Native Mass Spectrometry and Collision-Induced Unfolding of Laser-Ablated Proteins (2022)

Infrared laser ablation sample transfer (LAST) was used to collect samples from solid surfaces for mass spectrometry under native spray conditions. Native mass spectrometry was utilized to probe the charge states and collision-induced unfolding (CIU) characteristics of bovine serum albumin (BSA), bovine hemoglobin (BHb), and jack-bean concanavalin A (ConA) via direct injection electrospray, after liquid extraction surface sampling, and after LAST. Each protein was deposited from solution on solid surfaces and laser-ablated for off-line analysis or sampled for online analysis. It was found that the protein ion gas-phase charge-state distributions were comparable for direct infusion, liquid extraction, and laser ablation experiments. Moreover, calculated average collision cross section (CCS) values from direct injection, liquid extraction, and laser ablation experiments were consistent with previously reported literature values. Additionally, an equivalent number of mobility features and conformational turnovers were identified from unfolding pathways from all three methods for all charge states of each protein analyzed in this work. The presented work suggests that laser ablation yields intact proteins (BSA, BHb, and ConA), is compatible with native mass spectrometry, and could be suitable for spatially resolved interrogation of unfolding pathways of proteins.
Supplementary material for Uncorrected least-squares temporal difference with lambda-return (2019)

Here, we provide a supplementary material for Takayuki Osogami, "Uncorrected least-squares temporal difference with lambda-return," which appears in {\it Proceedings of the 34th AAAI Conference on Artificial Intelligence} (AAAI-20).
ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone (2014)

Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. As with all sarcomas, the prognosis of these diseases ultimately depends on the presence of metastatic disease. Survival is therefore closely linked with the biology and metastatic potential of a particular bone tumor's cells. Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, cultured human CSA cells, which are historically chemo- and radio-resistant, may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to draw broad conclusions from such a small series, the importance of ALDH activity and inhibition in the metastatic potential of primary bone sarcomas should be investigated further.
Haemodialysis filters: whatʼs new? (1999)

Haemodialysis techniques rely on efficient haemodialyzers that are utilized as solute and water exchangers. The haemodialyzer design has not changed significantly for many years. Only recently optimization of the blood compartment design, of the membrane structure and of the dialysate compartment geometry have been sought. This paper briefly reviews the most recent advances in the design and construction of haemodialyzers and points out the clinical impact of such innovations.
Wireless Connectivity for Remote and Arctic Areas – Food for Thought (2019)

This paper addresses various aspects that should be considered to improve the digital inclusion of remote, and specifically arctic areas, so that the geographical location would play a lesser role in equality among the people. To this end, technological challenges and potential solutions are discussed. They are further elaborated by three examples that have different architectural use case specific challenges for remote area wireless connectivity. The active role of society is seen pivotal alongside with the technological solutions to make this happen.
Fe-B Nanocapsules Characterized by Analytical Electron Microscopy (2003)

Journal Article Fe-B Nanocapsules Characterized by Analytical Electron Microscopy Get access J G Zheng, J G Zheng Electron Probe Instrumentation Center (EPIC), NUANCE; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208-3108, USA § Correspondence: Phone 847-491-7807, Fax: 847-491-7820, e-mail: j-zheng3@northwestern.edu Search for other works by this author on: Oxford Academic Google Scholar Z D Zhang, Z D Zhang Shenyang National Laboratory for Materials Science and International Center for Materials Physics, Institute of Metal Research, Academic Sinica, Shengyany 110015, P.R. China Search for other works by this author on: Oxford Academic Google Scholar V P Dravid V P Dravid Electron Probe Instrumentation Center (EPIC), NUANCE; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208-3108, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 9, Issue S02, 1 August 2003, Pages 276–277, https://doi.org/10.1017/S143192760344138X Published: 19 July 2003
Influence of Microstructure on Creep and High Strain Rate Fracture of Sn‐Ag‐Based Solder Joints (2012)

This chapter contains sections titled: Introduction Coarsening Kinetics: Quantitative Analysis of Microstructural Evolution Creep Behavior of Sn-Ag-Based Solders and the Effect of Aging Role of Microstructure on High Strain Rate Fracture Summary and Conclusions Acknowledgments References
Bovine Mammary Myoepithelial Cells. 1. Isolation, Culture, and Characterization (1992)

The objective of this study was to isolate, purify, culture, and characterize myoepithelial cells from bovine mammary glands. Myoepithelial cells were separated from other mammary and blood cells after collagenase digestion and centrifugation using metrizoate-ficoll gradients. Myoepithelial cells were identified by their characteristic morphology and cloned using selective detachment. They contained many densely packed myofilaments, very few cytoplasmic organelles, elongated surface projections, and a dense, irregularly shaped nuclei. Some cells were as large as 1.2 mm in culture. Myoepithelial cells contained an extensive network of cytoskeletal proteins, including alpha-smooth muscle actin, alpha-actinin, and vimentin. When cultured, they tended to repel one another and never grew as closely associated cells. The myoepithelial nature of these cells was verified by showing that they contracted in response to oxytocin, bound oxytocin, and did not produce casein. Myoepithelial cells from fetal and lactating glands grew very well in culture. Active division of myoepithelial cells could be maintained for at least 3 mo, and cells could be serially subcultured at least seven times. The successful isolation and culture of bovine mammary myoepithelial cells make utilization of these cells possible in order to study their role in mammary growth and differentiation and milk ejection.
Guest Editorial: Special Section on Image/Video Compression and Processing for Visual Communications (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.