gebhart/patrepeval huggingface dataset:
Compact DC Modeling of Organic Thin-Film Transistors Including Their Parasitic Non-Linear Contact Effects Based on a Novel Extraction Method (2019)

This article presents a novel generic method for the extraction of the current-voltage characteristics of organic thin-film transistors (TFTs) that specifically accounts for the individual contributions of the source and drain contacts and their nonlinear behavior. Based on this extraction method, an analytical model has been derived that describes the behavior of the intrinsic TFT and of the source and drain contacts both in the linear and the saturation regimes. The essential feature of the proposed extraction method is that it does not depend on or assume any physical phenomena underlying the electrical characteristics of the contacts. Instead, it extracts the current-voltage characteristics of the contacts which can then be fit to any physics-based TFT model. This is beneficial both for circuit designers and for those developing physics-based TFT models. The proposed extraction method has been applied to organic TFTs fabricated on flexible plastic substrates in the staggered and coplanar device architectures using two different small-molecule organic semiconductors. The compact dc model has been used to simulate organic TFTs with channel lengths ranging from 4 to 100 μm and a transimpedance amplifier circuit based on TFTs with different channel lengths, and the results are in good agreement with the measurements.
Inhibition of Raf-1 protein kinase by antisense phosphorothioate oligodeoxyribonucleotide is associated with sensitization of human laryngeal squamous carcinoma cells to gamma radiation. (1997)

These studies demonstrate that raf As-ODNs is a DNA sequence-specific radiosensitizer that may have potential for use in the radiation therapy of cancers.
Parameter estimation using the impulse response function for high affinity neuroreceptor ligands in PET (2002)

A tool for the complex task of multiparameter estimates from positron emission tomography (PET) and single photon emission computed tomography (SPECT) data, based on models of high affinity neuroreceptors ligands is presented. A simplified kinetic model of high affinity ligands and the mathematical background for the estimation of an impulse response function (IRF) from measured time activity curves are discussed. The advantages of this approach are that there is a straightforward relationship between the rate constants and the shape of the theoretical IRF, allowing a simplified parameter estimation process that in some cases will only yield one solution. Additionally, the estimated IRF allows a qualitative assessment of reliability of the estimates for each parameter and also an intuitive method of selectively weighting the data. Results based on simulated and measured N-methy-spiperone (NMSP) studies show that the IRF method is robust and also is a useful tool in conjunction with a standard three-parameter estimation algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks (2016)

Visterra, Inc.
Formation of 2-Trifluoromethylphenyl Grignard Reagent via Magnesium−Halogen Exchange: Process Safety Evaluation and Concentration Effect (2009)

The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5 M concentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The solution generated by employing Knochel’s magnesium−halogen exchange protocol showed highly exothermic decomposition. The decomposition begins at a low-onset temperature accompanied by a rapid temperature and pressure rise. Analysis of the decomposition mixture revealed the destruction of trifluoromethyl group and formation of fluoride ion. This decomposition profile was substantially attenuated by reducing the concentration of the solution to 0.5−0.6 M. Thus, it is strongly recommended that selecting an appropriate concentration for the reagent based on calorimetric evaluation should be included with procedural and engineering controls when considering any strategy for safe scale-up of trifluoromethyl-substituted phenyl Grignard solutions.
Designing an ultra-wideband electromagnetic waves receiver with new architecture for RF and wireless applications (2015)

This paper demonstrates an electromagnetic waves receiver (EMWR) with new architecture for finding the good performances at the very wide frequency range of 2.8 to 10.8 GHz. The proposed device applies conventional pulse position modulation (PPM) scheme for modulation. The combination of 8th–8th-order derivative of Gaussian pulse is used as impulse received signal. The EMW receiver circuit with core chip dimension of 32 × 10 −3 mm 2 was modeled in a 90 nm CMOS technology. The output amplitude pulse yielded 200 mV peak-to-peak under a supply voltage of 2.2 V. This circuit consumes 12 pJ/pulse at 0.5 GHz pulse-repeating frequency. The designed device can be employed in the transceiver systems in presence the multipath channel for 2.8 GHz to 10.8 GHz. Results express that the proposed system not only decrease the interference with narrowband (NB) systems, but is also robust against NB interference at the operating frequency of 7 GHz. Regarding to results, the EMWR can be used in radio frequency (RF) and wireless receiver applications.
ChemInform Abstract: Photochemistry of the Xanthene Dyes. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regiochemistry of Mercury(II) Oxide Oxidation of Unsymmetrical N,N‐ Disubstituted Hydroxylamines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Initiation of apoptosis by photodynamic therapy on MCF7 cells (2001)

This article has no abstract.
Influence of the three‐dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3 (2017)

Because cell interactions play a fundamental role for cell differentiation, we investigated the expression of Pannexin 1 and Pannexin 3 in human bone marrow mesenchymal stromal cells (HBMSCs) in a three-dimensional (3D) microenvironment provided by a polysaccharide-based macroporous scaffold. The pannexin (Panx) family consists of three members, Panx1, Panx2, and Panx3. The roles of Panx large-pore ion and metabolite channels are recognized in many physiological and pathophysiological scenarios, but the role of these proteins in human physiological processes is still under investigation. Our study demonstrates that HBMSCs cultured within 3D scaffolds have induced Panx1 and Panx3 expression, compared with two-dimensional culture and that the Panx3 gene expression profile correlates with those of bone markers on mesenchymal stromal cells culture into the 3D scaffold. We showed that Panx1 is involved in the HBMSCs 3D cell-cell organization, as acting on the size of cellular aggregates, demonstrated by the use of Probenecid and the mimetic peptide 10panx1 as specific inhibitors. Inhibition of Panx3 using siRNA strategy shows to reduce the expression of osteocalcin as osteoblast-specific marker by HBMSCs cultured in 3D conditions, suggesting a role of this Panx in osteogenesis. Moreover, we evaluated Panx1 and Panx3 expression within the cellularized scaffolds upon subcutaneous implantation in NOG (NOD/Shi-scid/IL-2Rγ<sup>null</sup> ) mice, where we could observe a more intense expression in the constructs than in the surrounding tissues in vivo. This study provides new insights on the expression of pannexins in HBMSCs on a 3D microenvironment during the osteogenic differentiation, in vitro and in vivo.
A Novel Collection Technique for the Improvement of Semen Quality (2014)

To date, the common thread in the use of semen extenders/collection techniques, whether they are being used for fresh extended semen, chilled semen, or cryopreserved semen, is that the extenders have all traditionally been added post-collection. The objective of this study was to determine if modifying the method of collection/extension of semen to include a warmed media environment would improve semen parameters by lessening cold and pH shock. Ten canine semen samples were collected with a modified artificial vagina to allow for a true split collection into to collection containers at one time. The treatment half of the sample was collected into a measured amount of warmed extension media. The control half was collected into a dry container and no attempts to maintain temperature was used. Standard semen parameters, available sperm pool, and number of inseminations were evaluated at specific time intervals and evaluations continued until samples reached zero percent motility. Data analysis was performed with SPSS using the general linear model and appropriate t-tests. There was a difference between the treatment and control groups for Motility (P<.001), Motility by Time (P<.001), Time to Zero Motility (P<.001), Time to Last Full Insemination (P<.03), Forward Progression (P<.001), Acrosome Reaction (P<.001), Acrosome Reaction by Time (P<.02) and Viability (P<.001). There was no difference in morphology between the treatment and control groups (P>.05). Modification of the semen collection/extension procedure resulted in improved semen parameters for extended time-periods post-collection. The data suggest the described collection technique can yield significantly more motile sperm by placing the sample into a physiologically favorable environment (eliminating pH and cold shock and allowing osmoregulation to begin), thus providing more available sperm for breeding.
Comparative Genomics of Klebsiella pneumoniae Strains with Different Antibiotic Resistance Profiles (2011)

There is a global emergence of multidrug-resistant (MDR) strains of Klebsiella pneumoniae, a Gram-negative enteric bacterium that causes nosocomial and urinary tract infections. While the epidemiology of K. pneumoniae strains and occurrences of specific antibiotic resistance genes, such as plasmid-borne extended-spectrum β-lactamases (ESBLs), have been extensively studied, only four complete genomes of K. pneumoniae are available. To better understand the multidrug resistance factors in K. pneumoniae, we determined by pyrosequencing the nearly complete genome DNA sequences of two strains with disparate antibiotic resistance profiles, broadly drug-susceptible strain JH1 and strain 1162281, which is resistant to multiple clinically used antibiotics, including extended-spectrum β-lactams, fluoroquinolones, aminoglycosides, trimethoprim, and sulfamethoxazoles. Comparative genomic analysis of JH1, 1162281, and other published K. pneumoniae genomes revealed a core set of 3,631 conserved orthologous proteins, which were used for reconstruction of whole-genome phylogenetic trees. The close evolutionary relationship between JH1 and 1162281 relative to other K. pneumoniae strains suggests that a large component of the genetic and phenotypic diversity of clinical isolates is due to horizontal gene transfer. Using curated lists of over 400 antibiotic resistance genes, we identified all of the elements that differentiated the antibiotic profile of MDR strain 1162281 from that of susceptible strain JH1, such as the presence of additional efflux pumps, ESBLs, and multiple mechanisms of fluoroquinolone resistance. Our study adds new and significant DNA sequence data on K. pneumoniae strains and demonstrates the value of whole-genome sequencing in characterizing multidrug resistance in clinical isolates.
Multiple Response Optimization of High Temperature, Low Time Aqueous Extraction Process of Phenolic Compounds from Grape Byproducts (2014)

In this study phenolic compounds extraction from grape byproducts was conducted using pure water as a solvent. High temperatures and low time incubation periods were used in the aim of reducing the cost of the process and heightening the phenolic compounds yield. Response surface methodology (RSM) was realized to study the effect of time and temperature on crushed and uncrushed grape pomace. The phenolic content was evaluated considering the quantity (total phenolics (TPC), flavonoids (FC), total monomeric anthocyanins (TMA) and tannins (TC)), and quality (antiradical activity (AA) and antioxidant capacity (AC)) of the extracts. High temperature low time extraction design used in this study was compared to the extraction process at moderate temperatures with relatively long periods of time. This was proved to ameliorate the quantitative extraction of phenolic compounds from grape pomace without affecting their bioactivity. Moreover, multiple response optimization showed the optimal extraction parameters to be 81?C and 140 minutes for the unmilled pomace samples, and 88?C and 5 minutes for the milled. TPC, FC, TMA, TC, AA and AC are almost the same for both optimums. Thus the possibility of replacing the milling process by the extraction time prolongation (for the unmilled pomace) of 135 minutes seems to be very plausible. HPLC analysis showed different quantity and diversity of extracted phenolics for the optimums. However this difference did not significantly affect the overall activity, showing that PC in the different extracts act in complete synergy all together leading to important biological properties. The obtained results using the extraction strategy adopted in this work could lead to several industrial applications.
Multi-feature-based plaque characterization inex vivoMRI trained by registration to 3D histology (2011)

We present a new method for automated characterization of atherosclerotic plaque composition in ex vivo MRI. It uses MRI intensities as well as four other types of features: smoothed, gradient magnitude and Laplacian images at several scales, and the distances to the lumen and outer vessel wall. The ground truth for fibrous, necrotic and calcified tissue was provided by histology and μCT in 12 carotid plaque specimens. Semi-automatic registration of a 3D stack of histological slices and μCT images to MRI allowed for 3D rotations and in-plane deformations of histology. By basing voxelwise classification on different combinations of features, we evaluated their relative importance. To establish whether training by 3D registration yields different results than training by 2D registration, we determined plaque composition using (1) a 2D slice-based registration approach for three manually selected MRI and histology slices per specimen, and (2) an approach that uses only the three corresponding MRI slices from the 3D-registered volumes. Voxelwise classification accuracy was best when all features were used (73.3 ± 6.3%) and was significantly better than when only original intensities and distance features were used (Friedman, p < 0.05). Although 2D registration or selection of three slices from the 3D set slightly decreased accuracy, these differences were non-significant.
Infrared Spectropolarimetry (1990)

This paper describes the infrared spectropolarimeter currently under development at the University of Alabama in Huntsville. The instrument, the data acquisition and processing algorithms, and several calibration issues are examined. Results are presented showing measurements of the retardance spectra of polarization elements, and the s- and p-transmission and diattenuation spectra of infrared coatings.
A Low-Loss Reconfigurable Plasma Impedance Tuner for Real-Time, Frequency-Agile, High-Power RF Applications (2022)

Many frequency bands, previously allocated solely for radar, are being designated for sharing. Future radar transmitters must adaptively share the frequency spectrum with wireless communications, requiring high-power, high-speed reconfigurable circuits to maximize radar detection range upon changes in frequency and antenna impedance. This paper presents an octave (2–4 GHz) S-band reconfigurable impedance tuner with 35 W plasma switches connecting shunt inductors and capacitors to a series feedline. The tuner can be reoptimized to maximize output power in approximately 300 μs upon changes in operating frequency or antenna impedance. The tuner has a much lower average insertion loss (2.5 dB) and comparable optimization times when compared with the previous state-of-the-art octave S-band plasma tuner. The new design significantly reduces loss over its octave tuning range using shunt inductors and capacitors instead of open-circuited stubs.
Supplementary Table 1 from Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy (2023)

&lt;p&gt;XLSX file - 2238K, Complete kinome compendium of all tissue types by RNA-Seq.&lt;/p&gt;
Chemoselective Caging of Carboxyl Groups for On‐Demand Protein Activation with Small Molecules (2023)

Abstract Tools for on‐demand protein activation enable impactful gain‐of‐function studies in biological settings. Thus far, however, proteins have been chemically caged at primarily Lys, Tyr, and Sec, typically through the genetic encoding of unnatural amino acids. Herein, we report that the preferential reactivity of diazo compounds with protonated acids can be used to expand this toolbox to solvent‐accessible carboxyl groups with an elevated p K a value. As a model protein, we employed lysozyme (Lyz), which has an active‐site Glu35 residue with a p K a value of 6.2. A diazo compound with a bioorthogonal self‐immolative handle esterified Glu35 selectively, inactivating Lyz. The hydrolytic activity of the caged Lyz on bacterial cell walls was restored with two small‐molecule triggers. The decaging was more efficient by small molecules than by esterases. This simple chemical strategy was also applied to a hemeprotein and an aspartyl protease, setting the stage for broad applicability.
Preparation of Mesogen-Functionalized Dendrimers for Second-Order Nonlinear Optics (2002)

Liquid crystalline dendrimers with peripheral mesogen-containing units have been prepared. Multistep synthesis with several selective reactions was used in the preparation of the mesogen-containing molecules, 4‘ ‘-[10-(hydroxycarbonyl)decyloxy]phenyl 4-[4‘-(2-(R)-octyloxy)-3‘-nitrophenyl]benzoate and 4‘ ‘-[10-(hydroxycarbonyl)decyloxy]biphenyl 4-[4‘-(2-(R)-octyloxy)-3‘-nitrophenyl]benzoate. Both molecules possessed an electron-accepting nitro group placed perpendicular to the long axis of the molecules in order to enhance the nonlinear optical activity. A second generation hydroxyl functional aliphatic dendrimer based on the dihydroxy acid, 2,2-bis(hydroxymethyl)propionic acid, was used as dendritic scaffold and was subsequently functionalized with the aforementioned groups. The purity and structure of the two liquid crystalline dendrimers were determined by 1H NMR spectroscopy, size exclusion chromatography, and elemental analysis. The synthesis of both the mesogen-containing units and the liquid crystalline dendrimers is described in detail. Investigation of the liquid crystalline properties of the materials by differential scanning calorimetry and optical microscopy showed that they exhibited different mesophases, including the chiral smectic C phase. Ferroelectric switching was observed in this tilted phase, and electrooptical properties, including tilt angle and spontaneous polarization measurements, were investigated. Finally, the nonlinear optical properties of one of the materials were preliminary characterized.
Subpapillary continuous sling suturing method for soft tissue grafting with the tunneling technique. (2010)

This paper describes a new suturing method, the subpapillary continuous sling suture, for use with soft tissue grafts in tunnel procedures to treat gingival recession. This method combines the graft suture and the sutures used to advance the pouch margins over the graft into a single continuous sling suture. It is indicated particularly for sites with shallow recessions and those treated for augmentation rather than root coverage because of a lack of graft access for standard suture placement. The single-suture method may also be used for sites with moderate to severe recession. The advantages of this method include elimination of the need to place additional sutures for coronal advancement of the pouch, resulting in reduced suturing time and reduced opportunity to inadvertently cut the continuous suture with the needle when suturing the pouch.
Performance Envelope and Physiological Tremor in Microsurgery (2006)

Using an instrumented surgical tool, high-precision recordings of hand tremor were taken during vitreoretinal microsurgery in a rabbit model in vivo. The data obtained using a compact, custom six-degree-of-freedom inertial sensing module were filtered and analyzed to characterize the physiological hand tremor of the surgeon. Tremor during the most delicate part of the procedure was measured at a vector magnitude of 30 μm rms. Non-tremulous, lower-frequency components of instrument movement were also characterized. The data collected provide an important baseline for design specification and performance evaluation of microsurgical devices, using a more comprehensive data set than has been evaluated previously.
DETECTION OF DELAMINATION DEFECTS AT THE CONCRETE/FRP COMPOSITE INTERFACE OF LONGITUDINAL AND LAMB WAVES (1998)

Fiber Reinforced Plastic (FRP) composites are fast becoming a viable new construction material. These are being used for rehabilitating old concrete structures - bridges, buildings, columns, beams and retaining walls - by gluing the composite plate to the concrete surface. Proper attachment between the FRP plate and the concrete surface is necessary for efficient use of the FRP composites to increase the strength of the rehabilitated structures. Delamination between the rehabilitated structure and the FRP plate significantly reduces the strength of the reinforced structure. Hence, delamination defects, if present at the interface, should be detected as soon as possible. In this paper, two ultrasound techniques to detect delamination defects between the FRP plate and the concrete surface are presented. One technique uses longitudinal waves and the second technique uses Lamb waves. It is found that both techniques can detect the defect when used properly. However, Lamb waves give better image of the defect than the longitudinal waves.