gebhart/patrepeval huggingface dataset:
α-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury (2002)

The anti-inflammatory cytokines alpha-melanocyte-stimulating hormone (MSH) and interleukin (IL)-10 inhibit acute renal failure (ARF) after ischemia or cisplatin administration; however, these agents have not been tested in a pure nephrotoxic model of ARF. Therefore, we examined the effects of alpha-MSH and IL-10 in HgCl(2)-induced ARF. Mice were injected subcutaneously with HgCl(2) and then given vehicle, alpha-MSH, or IL-10 by intravenous injection. Animals were killed to study serum creatinine, histology, and myeloperoxidase activity. Treatment with either alpha-MSH or IL-10 did not alter the increase in serum creatinine, tubular damage, or leukocyte accumulation at 48 h after HgCl(2) injection. Because alpha-MSH and IL-10 are active in other injury models that involve leukocytes, we studied the time course of tubular damage and leukocyte accumulation to investigate whether leukocytes caused the tubular damage or accumulated in response to the tubular damage. Tubular damage was present in the outer stripe 12 h after HgCl(2) injection. In contrast, the number of leukocytes and renal myleoperoxidase activity were normal at 12 h but were significantly increased at 24 and 48 h after injection. We conclude that neither alpha-MSH nor IL-10 altered the course of HgCl(2)-induced renal injury. Because the tubular damage preceded leukocyte infiltration, the delayed leukocyte accumulation may play a role in the removal of necrotic tissue and/or tissue repair in HgCl(2)-induced ARF.
Pickup for Small Form Factor Optical Drive with 2.3 mm Height Actuator (2005)

Recently, with the requirements of several mobile products coming to the fore, to cope with the market needs, various mobile storage applications have been developed. Moreover, the core components and technologies for mobile optical disc drives have been under continuous development. In the case of optical storage, a small optical pickup is required to realize a mobile optical disc drive, because the optical parts and an actuator are the main factors determining the optical pickup height. In this paper, we examine the 5-mm-high mobile small form factor optical (SFO) drive and achieve a good readout signal with 6.8% jitter using a limit equalizer. In addition, the use of 2.3-mm-high actuator with a horizontally arranged magnetic circuit for the mobile pick up reduces the height of optical pickup, and leads to high DC and AC sensitivity for low power consumption.
Polymerization of methyl methacrylate with non-bridged zirconocene catalysts (1998)

Four non-bridged dimethylzirconocene complexes, i.e., bis(η5-cyclopentadienyl)dimethylzirconium (1), (η5-cyclopentadienyl) (η5-fluorenyl)dimethylzirconium (2), bis(η5-indenyl)dimethylzirconium (3) and (η5-cyclopentadienyl)(η5-pentamethylcyclopentadienyl)dimethylzirconium (4) were synthesized and used as a catalyst for the methyl methacrylate polymerization combined with triphenylmethyl tetrakis(pentafluorophenyl)borate in the presence of ZnEt2 or Al(i-Bu)3. The catalyst activity strongly depends on the zirconocene compound and decreases in the order 2 > 1 > 3 ≫ 4. The polymerization proceeds in a living manner when 1 and 2 are used combined with ZnEt2. On the other hand, stereoregularities of the resulting polymers are independent of the zirconocene compound, and syndiotactic-rich polymers are formed by a chain-end controlled mechanism.
Simple, Facile, and One‐Pot Conversion of the Baylis—Hillman Adducts into Functionalized 1,2,3,4‐Tetrahydroacridines and Cyclopenta[b]quinolines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Fractured Rock Geophysical Toolbox Method Selection Tool (2016)

Article impact statement : A spreadsheet‐based software is presented to identify methods for use at fractured‐rock sites, based on project goals and site description.
Equalizing Well Pressure Drop with Swirl Chambers (2015)

Abstract The present paper is concerned with a numerical study of swirl flows applied as a pressure equalization means in an inflow control devices (ICD) setup. The system discussed includes an isolated mechanical flow path that is designed as a conical channel through which the produced fluids are injected with a tangential inlet. The system forms a swirl chamber that generates a swirling flow that decays along the flow path. The active swirl part arrangement could be mounted in serial sections along the flow path to maintain the swirl properties of the flow over the desired distance. The swirl motion generates a pressure drop that is related to the length, gap width, and tangential inlet size of the swirl element. The present work presents a numerical investigation of this system by studying the primary flow variables using a finite difference method. The numerical results revealed the flow nature and the resulting pressure drops with regard to the flow system variables.
Electron transport in ZnO thin films (2010)

Epitaxial n-type ZnO films grown by a laser molecular-beam epitaxy method were investigated by the temperature-dependent Hall-effect technique. The 300 K carrier concentration and mobility were about n(s) similar to 10(16) cm(-3) and 440 cm(2)/V s, respectively. Transport characteristics are calculated by solving the Boltzmann transport equation using a variational method. Mobility limit of 430 cm(2)/V s was calculated at 300 K. The temperature dependence of the mobility for an undoped film is calculated and agrees favorably well with experimental data if physical parameters are chosen so as to approach those. In the experimental "mobility versus concentration" curve, unusual phenomenon was observed, i.e., mobilities at n(s) similar to 5 x 10(18) cm(-3) are significantly smaller than those at higher densities above similar to 10(20) cm(-3). It is qualitatively explained in terms of electron-plasmon interaction.
DPS - Dynamic Parallel Schedules (2004)

Dynamic Parallel Schedules (DPS) is a high-level framework for developing parallel applications on distributed memory computers (e.g. clusters of PC). Its model relies on compositional customizable split-compute-merge graphs of operations (directed acyclic flow graphs). The graphs and the mapping of operations to processing nodes are specified dynamically at runtime. DPS applications are pipelined and multithreaded by construction, ensuring a maximal overlap of computations and communications. DPS applications can call parallel services exposed by other DPS applications, enabling the creation of reusable parallel components. The DPS framework relies on a C++ class library. Thanks to its dynamic nature, DPS offers new perspectives for the creation and deployment of parallel applications running on server clusters.
J/ψ suppression at forward rapidity in Pb–Pb collisions at sNN=5.02 TeV (2017)

Made available in DSpace on 2017-08-17T19:09:20Z (GMT). No. of bitstreams: 1\n2-s2.0-85010002500.pdf: 1046566 bytes, checksum: 8626f1cd0abeec9e58bc336f7910f269 (MD5)\n Previous issue date: 2017
Culture negative empyema in a critically ill child: an opportunity for rapid molecular diagnostics (2014)

Using this method, Streptococcus mitis/viridans was identified as the pathogen. A retrospective review of cases of empyema in children at our institution found that 87.5% of cases were negative for identification of a pathogen and antibiotics were administered to 100% of cases prior to collecting pleural fluid for culture. Understanding the role of Streptococcus mitis/viridans group in the etiology of empyema using an advanced NAAT coupled with mass spectrometry can enlighten clinicians as to the impact of this pathogen in community acquired pneumonia and help assist with antibiotic stewardship.
Operator-free, film-based 3D seed reconstruction in brachytherapy (2002)

In brachytherapy implants, the accuracy of dose calculation depends on the ability to localize radioactive sources correctly. If performed manually using planar images, this is a time-consuming and often error-prone process-primarily because each seed must be identified on (at least) two films. In principle, three films should allow automatic seed identification and position reconstruction; however, practical implementation of the numerous algorithms proposed so far appears to have only limited reliability. The motivation behind this work is to create a fast and reliable system for real-time implant evaluation using digital planar images obtained from radiotherapy simulators, or mobile x-ray/fluoroscopy systems. We have developed algorithms and code for 3D seed coordinate reconstruction. The input consists of projections of seed positions in each of three isocentric images taken at arbitrary angles. The method proposed here consists of a set of heuristic rules (in a sense, a learning algorithm) that attempts to minimize seed misclassifications. In the clinic, this means that the system must be impervious to errors resulting from patient motion as well as from finite tolerances accepted in equipment settings. The software program was tested with simulated data, a pelvic phantom and patient data. One hundred and twenty permanent prostate implants were examined (105 125I and 15 103Pd) with the number of seeds ranging from 35 to 138 (average 79). The mean distance between actual and reconstructed seed positions is in the range 0.03-0.11 cm. On a Pentium III computer at 600 MHz the reconstruction process takes 10-30 s. The total number of seeds is independently validated. The process is robust and able to account for errors introduced in the clinic.
Taste 2 receptors in GtoPdb v.2023.1 (2023)

Taste 2 receptors or Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed in oral sensory cells and a variety of non-gustatory tissues. The ~25 human TAS2Rs share low amino acid sequence identities with other GPCR families and are classified as broadly tuned "generalist" receptors with numerous, chemically diverse bitter agonists, as narrowly tuned "specialist" receptors with very few activators, as intermediately tuned receptors with an average number of agonists, or receptors specialized to interact with chemically defined activators [32]. The number of functional bitter taste receptor genes varies among species and orthologues might not be functionally conserved. Due to their expression in various tissues, the signal transduction of TAS2Rs is complex. Some TAS2Rs interact with drugs such as analgesic, anti-inflammatory, and antibacterial compounds. The specialist database BitterDB contains additional information on bitter compounds and receptors [14].
Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells (2001)

The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many receptors, including FcepsilonRI. Vav1-deficient mice contain normal numbers of mast cells but respond more weakly than their normal counterparts to a passive systemic anaphylaxis challenge. Vav1-deficient bone marrow-derived mast cells also exhibited reduced degranulation and cytokine production, although tyrosine phosphorylation of FcepsilonRI, Syk, and LAT (linker for activation of T cells) was normal. In contrast, tyrosine phosphorylation of phospholipase Cgamma1 (PLCgamma1) and PLCgamma2 and calcium mobilization were markedly inhibited. Reconstitution of deficient mast cells with Vav1 restored normal tyrosine phosphorylation of PLCgamma1 and PLCgamma2 and calcium responses. Thus, Vav1 is essential to FcepsilonRI-mediated activation of PLCgamma and calcium mobilization in mast cells. In addition to its known role as an activator of Rac1 GTPases, these findings demonstrate a novel function for Vav1 as a regulator of PLCgamma-activated calcium signals.
Comparative Analysis of the Humoral Immune Response to Moraxella catarrhalis and Streptococcus pneumoniae Surface Antigens in Children Suffering from Recurrent Acute Otitis Media and Chronic Otitis Media with Effusion (2012)

A prospective clinical cohort study was established to investigate the humoral immune response in middle ear fluids (MEF) and serum against bacterial surface proteins in children suffering from recurrent acute otitis media (rAOM) and chronic otitis media with effusion (COME), using Luminex xMAP technology. The association between the humoral immune response and the presence of Moraxella catarrhalis and Streptococcus pneumoniae in the nasopharynx and middle ear was also studied. The levels of antigen-specific IgG, IgA, and IgM showed extensive interindividual variation. No significant differences in anti-M. catarrhalis and anti-S. pneumoniae serum and MEF median fluorescence intensity (MFI) values (anti-M. catarrhalis and antipneumococcal IgG levels) were observed between the rAOM or COME groups for all antigens tested. No significant differences were observed for M. catarrhalis and S. pneumoniae colonization and serum IgG levels against the Moraxella and pneumococcal antigens. Similar to the antibody response in serum, no significant differences in IgG, IgA, and IgM levels in MEF were observed for all M. catarrhalis and S. pneumoniae antigens between OM M. catarrhalis- or S. pneumoniae-positive and OM M. catarrhalis- or S. pneumonia-negative children suffering from either rAOM or COME. Finally, results indicated a strong correlation between antigen-specific serum and MEF IgG levels. We observed no significant in vivo expressed anti-M. catarrhalis or anti-S. pneumoniae humoral immune responses using a range of putative vaccine candidate proteins. Other factors, such as Eustachian tube dysfunction, viral load, and genetic and environmental factors, may play a more important role in the pathogenesis of OM and in particular in the development of rAOM or COME.
Behavioral Modeling of Power Amplifiers With Modern Machine Learning Techniques (2019)

In this study, modern machine learning (ML) methods are proposed to predict the dynamic non-linear behavior of wideband RF power amplifiers (PAs). Neural networks, k- nearest neighbor, and several tree-based ML algorithms are first adapted to handle complex-valued signals and then applied to the PA modeling problem. Their modeling performance is evaluated with measured data from two basestation PAs. Gradient boosting is seen to outperform the other ML approaches and to give comparable performance to the generalized memory polynomial (GMP) reference model in terms of both the normalized mean squared error (NMSE) and adjacent channel error power ratio (ACEPR). This is the first study int he open literature to consider modern ML approaches, besides neural networks, for PA behavioral modeling.
Infection Following Implant-Based Breast Reconstruction (2012)

INTRODUCTION: Few studies address salvage rates for infection in implant-based breast reconstruction. An understanding of success rates and clinical predictors of failure may help guide management. METHODS: Retrospective analysis of multi-surgeon consecutive implant-based reconstructions from July 2004 to December 2010. RESULTS: 1952 immediate implant-based reconstructions were performed in 1241 patients. 99 (5.1%) reconstructions were admitted for infection. These patients had a higher incidence of smoking (p<0.01), chemotherapy (p<0.01) and radiation (p<0.001). There was no difference in age, BMI, or acellular dermal matrix (ADM) usage. With intravenous antibiotics, 25 (25.3%) reconstructions cleared infection while 74 (74.7%) underwent attempted operative salvage (18) or explant (56). Patients who failed to clear infection medically had a higher average wbc (p<0.002) and higher absolute wbc >10,000 (p<0.03). There was no difference in ADM usage. Of the attempted immediate salvage group, 12 cleared the infection with immediate implant exchange and 6 eventually lost the implant. Patients who failed implant salvage were more likely to have MRSA (p<0.006). Following explantation, 32 patients had delayed tissue expander (TE) insertion (average 150 days), 6 had delayed autologous flap reconstruction (average 139 days), 13 had no further reconstruction. Of the delayed TE insertions, 26 were successful and 6 had recurrent infection resulting in implant loss. There were no differences in time interval to delayed TE insertion between successful and unsuccessful secondary delayed surgeries. CONCLUSION: Salvage of the infected breast prosthesis remains a challenging yet viable option for a subset of patients. Salvage with intravenous antibiotics and/or implant exchange was successful in 37.3% of patients. Smoking, radiation, and chemotherapy were significant predictors for developing infection. Patients with a WBC>10,000 and MRSA were more likely to fail implant salvage attempts. There was no association with time interval between delayed TE insertion and secondary explant or ADM usage (Figure 1).Figure 1: Predictors of infection and failure of implant salvage. * ADM usage showed no statistical significance.
Coexistence and transmission of multiple radios over seamless fiber-wireless systems (2017)

In this paper, we present efficient solutions for simultaneous transmission of multiple radio signals over seamless fiber wireless systems, including radio signals in legacy microwave bands and in high frequency bands. At central stations, radio signals can be mapped onto the same optical transport channel using data mapping algorithms and/or subcarrier multiplexing technique. After the fiber transmission, the received signals can be down-converted, digitized, and de-mapped to recover the originally transmitted signals. We present and compare two different methods, including a radio-over-fiber system and optical up-conversion at remote sites and an intermediate-frequency-over-fiber system and an electrical up-conversion at remote sites. We experimentally confirm the suitability of both the transmission methods, and achieve satisfactory performance for all signals, including LTE-advanced, orthogonal frequency-division multiplexing, and filtered-orthogonal frequency-division multiplexing signals. In particular, the latter method can provide a high optical spectral efficiency and low fiber dispersion effect and is suitable for ultra-dense small cell deployment in future mobile networks.
BQ: A Lock-Free Queue with Batching (2022)

Concurrent data structures provide fundamental building blocks for concurrent programming. Standard concurrent data structures may be extended by allowing a sequence of operations to be submitted as a batch for later execution. A sequence of such operations can then be executed more efficiently than the standard execution of one operation at a time. In this article, we develop a novel algorithmic extension to the prevalent FIFO queue data structure that exploits such batching scenarios. An implementation in C++ on a multicore demonstrates significant performance improvement of more than an order of magnitude (depending on the batch lengths and the number of threads) compared to previous queue implementations.
Variability in responses observed in human white adipose tissue models (2017)

Obesity is a risk factor for a myriad of diseases including diabetes, cardiovascular dysfunction, cirrhosis, and cancer, and there is a need for new systems to study how excess adipose tissue relates to the onset of disease processes. This study provides proof-of-concept patient-specific tissue models of human white adipose tissue to accommodate the variability in human samples. Our 3D tissue engineering approach established lipolytic responses and changes in insulin-stimulated glucose uptake from small volumes of human lipoaspirate, making this methodology useful for patient specific sample source assessments of treatment strategies, drug responses, disease mechanisms, and other responses that vary between patients. Mature unilocular cells were maintained ex vivo in silk porous scaffolds for up to a month of culture and imaged non-invasively with coherent anti-Stokes Raman scattering. Interestingly, differences in responsiveness between tissues were observed in terms of magnitude of lipolysis, ability to suppress lipolysis, differences in glucose uptake, and lipid droplet size. Body mass index was not a factor in determining tissue responsiveness; rather, it is speculated that other unknown variables in the backgrounds of different patients (ethnicity, athleticism, disease history, lifestyle choices, etc.) likely had a more significant effect on the observed differences. This study reinforces the need to account for the variability in backgrounds and genetics within the human population to determine adipose tissue responsiveness. In the future, this tissue system could be used to inform individualized care strategies-enhancing therapeutic precision, improving patient outcomes, and reducing clinical costs.
Gag-Specific Cytotoxic Responses to HIV Type 1 Are Associated with a Decreased Risk of Progression to AIDS-Related Complex or AIDS (1995)

The duration of human immunodeficiency virus (HIV-1) infection prior to the development of AIDS is variable, and for most patients the exact time of infection is not known. A group of 38 HIV-1-infected subjects was tested while asymptomatic for comparative cytotoxic lymphocyte responses to the Gag and envelope antigens of HIV-1. Twenty of the 38 patients had no detectable primary cytotoxic T lymphocyte (CTL) response to Gag, and this was associated with a relative risk of 1.89 for progression to ARC or AIDS during the subsequent 3 to 40 months of observation when compared with patients who had Gag-specific CTL activity at the beginning of the observation period. In contrast, no significant association was observed between envelope-specific cytotoxic activity and disease progression. Other patient characteristics, including CD4+ T lymphocyte counts and antibody levels to the p24gag protein, measured at the start of observation, did not correlate with disease progression during the observation period. This suggests that the anti-Gag CTL response may be protective during HIV-1 infection.
Multipronged functional proteomics approaches for global identification of altered cell signalling pathways in B‐cell chronic lymphocytic leukaemia (2016)

Chronic lymphocytic leukaemia (CLL) is a malignant B cell disorder characterized by its high heterogeneity. Although genomic alterations have been broadly reported, protein studies are still in their early stages. Herein, a 224-antibody microarray has been employed to study the intracellular signalling pathways in a cohort of 14 newly diagnosed B-CLL patients as a preliminary study for further investigations. Several protein profiles were differentially identified across the cytogenetic and molecular alterations presented in the samples (deletion 13q14 and 17p13.1, trisomy 12, and NOTCH1 mutations) by a combination of affinity and MS/MS proteomics approaches. Among others altered cell signalling pathways, PKC family members were identified as down-regulated in nearly 75% of the samples tested with the antibody arrays. This might explain the rapid progression of the disease when showing p53, Rb1, or NOTCH1 mutations due to PKC-proteins family plays a critical role favouring the slowly progressive indolent behaviour of CLL. Additionally, the antibody microarray results were validated by a LC-MS/MS quantification strategy and compared to a transcriptomic CLL database. In summary, this research displays the usefulness of proteomic strategies to globally evaluate the protein alterations in CLL cells and select the possible biomarkers to be further studied with larger sample sizes.