gebhart/patrepeval huggingface dataset:
Reports on CBMI 16 and ICME 16 (2016)

This issue features not just one but two conference reports. The first covers the 14th International Workshop on Content-Based Multimedia Indexing (CBMI 16), while the second covers the 2016 IEEE International Conference on Multimedia and Expo (ICME 2016). For both, find out what hot topics and key themes were discussed, which submissions earned the Best Paper awards, and more.
Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma (2021)

Receptor expression levels correlated with the level of peptide internalization and aggressiveness of the tumor. This study highlights the potential to exploit the expression of tumor-penetrating peptide receptors as a predictive marker of liver tumor aggressiveness. These bi-functional peptides could be developed for personalized tumor treatment.
Thermoelectric properties of delafossite-type layered oxides AgIn1−xSnxO2 (2005)

The thermoelectric properties of delafossite-type layered oxides AgIn1−xSnxO2 that consist of alternating layers of Ag and In1−xSnxO2 were investigated to elucidate their potential as a thermoelectric material. Polycrystalline materials of the AgIn1−xSnxO2 were prepared by a cation exchange reaction between NaIn1−xSnxO2 and AgCl. The solubility limit of the Sn atoms on the In sites was approximately x=0.05. The electrical conductivity and Seebeck coefficient were measured between 373 and 673K in air. Undoped AgInO2 was an n-type semiconductor with conductivities of 10−4–10−2Ω−1cm−1, and the electron carriers were generated via the formation of oxygen vacancies. AgIn0.95Sn0.05O2 was an n-type degenerate semiconductor with conductivities of 100–101Ω−1cm−1 where the Sn atoms acted as electron donors. This drastic increase in the electrical conductivity increased the thermoelectric power factor by approximately two orders of magnitude to 10−6–10−5Wm−1K−2.
On the estimation of specific surface per unit pore volume from induced polarization: A robust empirical relation fits multiple data sets (2010)

Abstract We analyze the relationship between induced polarization (IP) parameters and the specific surface area normalized to the pore volume (Spor) for an extensive sample database. We find that a single linear imaginary conductivity-Spor relation holds across a range of single-frequency IP data sets composed of sandstones and unconsolidated sediments that lack an appreciable metallic mineral content. We also apply a recent approach defined as Debye decomposition (DD) to determine normalized chargeability (mn), a global estimate of polarization magnitude from available spectral IP (SIP) data sets. A strong linear relationship between mn and Spor is also found across multiple data sets. However, SIP model parameters determined for samples containing metallic minerals are approximately two orders of magnitude greater than for the model parameters estimated for the nonmetallic sample database. We propose a concept of “polarizability of the mineral-fluid interface per unit Spor” to explain this difference, which is supported by the observed dependence of IP parameters on fluid conductivity between sample types. We suggest that this linear IP-Spor relation can be considered the IP equivalent of the classical Archie empirical relation. Whereas the Archie relation describes a power-law relation between electrical conductivity due to electrolytic conduction through the available interconnected pore volume, the IP-Spor relation is an equivalent relation between mineral-fluid interfacial polarization and available pore surface area.
Photonic crystal slab reflectors for compact passive and active optical devices (2007)

Compact photonic crystal mirrors (PCM) formed in suspended InP membranes are theoretically and experimentally studied under normal incidence. They are based on the coupling of free space waves with slow Bloch modes of the crystal. These mirrors provide high-efficiency and broadband reflectivity (stop-band superior to 400nm), when involving two slow Bloch modes of the crystal. They allow also for an accurate control of the polarization. These PCMs can be used in new photonic devices, where they replace DBR mirrors. The authors report on the demonstration of a compact and highly selective (Q>1000) tunable filter at 1.55&mgr;m, using a Fabry-Perot resonator combining a bottom micromachined 3-pair-InP/air-gap Bragg reflector with a top InP/air PCM. Micromechanical tuning of the device via electrostatic actuation is also demonstrated over a 20nm range for a maximum 4V tuning voltage. The active version of this device is also considered: a PCM-VCSEL is studied, combining a solid 40 quarter wavelength InP/InGaAlAs DBR with a top PCM. First experimental results show a high Q-factor (around 2000) compatible with a laser regime. We finally demonstrate in this paper a vertical-cavity Fabry-Perot filter with ultimate compactness, associating two PCMs.
3D reconstruction under light ray distortion from parametric focal cameras (2016)

In this paper, we propose a new camera model for reconstructing 3D objects under light ray distortion caused by refractive medias. The proposed method can reconstruct 3D scene, even if light rays projected into the cameras are refracted by the refractive media, such as glasses and raindrops. For this objective, we represent light ray projection of multiple cameras by using a pair of planes shared by the multiple cameras in the scene. By using this model, intrinsic and extrinsic camera parameters as well as the refractive properties of the refractive media can be represented efficiently. By using the newly defined camera model, we propose a method for recovering 3D points and camera parameters with refractive properties simultaneously. The experimental results show the efficiency of the proposed camera model and reconstruction method.
Comparative Effectiveness of Treatments for Chronic Low Back Pain (2017)

All 4 treatments provided some benefit to patients with chronic LBP. According to the MTC analysis, TDR may be the most effective treatment and PT the least effective treatment for chronic LBP. This review is based on a limited number of RCT studies and does not support any 1 treatment modality for all patients.
H2O2-Depleting and O2-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages (2017)

Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity. Electron paramagnetic resonance (EPR) and diphenylanthracene (DPA) quenching studies revealed that the SeNPs that were coated with the photosensitive layer were more effective than RB alone in producing singlet oxygen (<sup>1</sup>O<sub>2</sub>) under photoirradiation. The second layer of the activated macrophage-targetable macromolecule was synthesized by conjugation of hyaluronic acid with folic acid using an ethylenediamine linker. Proinflammatory-activated macrophages rapidly internalized the SeNPs that were covered with the targeting ligand, exhibiting a much stronger fluorescence signal of the SeNPs than did the nonactivated macrophages. Since proinflammatory-activated macrophage was known to generate a substantial amount of H<sub>2</sub>O<sub>2</sub> while the inflamed site generally caused inflammation-associated tissue hypoxia, the SeNPs were further modified with O<sub>2</sub> self-sufficient function for photodynamic therapy. Catalase was immobilized on the SeNPs by the formation of disulfide bonds. Intracellular reduction of disulfide bonds induced the subsequent release of catalase, which catalyzed the decomposition of H<sub>2</sub>O<sub>2</sub>. The H<sub>2</sub>O<sub>2</sub>-depleting and O<sub>2</sub>-generating photodynamic SeNPs efficiently killed activated macrophages and quenched the intracellular H<sub>2</sub>O<sub>2</sub> and NO that are associated with inflammation. The SeNPs may have potential as a theranostic nanomaterial to image and control the activation of macrophages.
The optimal approach to recursive programs (1977)

The classical fixedpoint approach toward recursive programs suggests choosing the “least defined fixedpoint” as the most appropriate solution to a recursive program. A new approach is described which introduces an “optimal fixedpoint,” which, in contrast to the least defined fixedpoint, embodies the maximal amount of valuable information embedded in the program. The practical implications of this approach are discussed and techniques for proving properties of optimal fixedpoints are given. The presentation is informal, with emphasis on examples.
Anti-Stokes cooling and other thermal managements techniques in fiber lasers and amplifiers (2022)

Heat generation during the operation of lasers and amplifiers negatively affects a wide range of performance and packaging considerations. Accordingly, the thermal management of such systems remains of critical importance. This paper reviews the sources of heat in active fiber lasers and amplifiers, and describes recent successes using all-optical means to reduce heat generation, including anti-Stokes fluorescence cooling, radiation balancing, and dual-wavelength pumping.
Stable denoising-enhancement of images by telegraph-diffusion operators (2013)

The recently-proposed family of Telegraph-Diffusion (TeD) operators is analyzed in the context of image enhancement. Stability of such schemes in terms of energy convergence is investigated and compared with that of the widely-used diffusion-based schemes, thereby resolving the Perona-Malik paradox. The results indicating stability are further generalized in the context of the Forward-and-Backward (FAB) TeD enhancement operator. An approximated version of the enhancement operator that offers an increased stability is proposed and examined. This scheme is implemented in both stable and unstable regimes of the original FAB-TeD operator and shown to yield results similar to those obtained by the latter, without losing stability. The theoretical conclusions regarding stability of the approximated FAB-TeD are reinforced by simulations, exhibiting enhanced images with sharpened edges and yet very limited compromise on the quality of other image details.
Communication technologies for exascale systems (2009)

Scaling computing systems to Exaflops (10<sup>18</sup> floating point operations per second) will require tremendous increases in communications bandwidth but with greatly reduced power consumption per communicated bit as compared to today's petaflop machines. Reaching the required performance in both density and power consumption will be extremely challenging. Electrical and optical interconnect technologies that may be part of the solution are summarized, including advanced electrical printed circuit boards, VCSEL-array based optical interconnects over multimode fibers or waveguides, and singlemode silicon photonics. The use of optical interconnects will play an ever-larger role in intrasystem communications. Although optics is used today primarily between racks, it will gradually migrate into backplanes, circuit cards, and eventually even on-chip. Keywords: optical interconnects, supercomputers, exascale,
Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model (2004)

To facilitate quantitation of cellular apoptotic responses to various antineoplastic agents, a laser-based technology, Optophoresis, has been developed to provide analysis of cells without any need for labeling or cell processing. Optophoresis is defined as the analysis of the motion of cells, where the motion is either induced or modified by a moving optical gradient field, which produces radiation pressure forces on the cells in an aqueous suspension. Quantitation of the induced motion provides a basis for distinguishing one population of cells from another. One Optophoretic technique, Fast Scan, measures the distribution of distances traversed by a population of cells when exposed to a fast-moving optical gradient. Fast Scan was validated using a cell-based model of chronic myeloid leukemia treated with Gleevec, a specific inhibitor of aberrant Bcr-Abl protein kinase. The Optophoretic measurements were quantitatively comparable to reference assays with regard to drug selectivity and potency and to target specificity, demonstrating the suitability of this technology for pharmaceutical and clinical applications.
A new unifying structural model of heteropolymolybdate salts: Microstructure and thermal stability of a series of molecular oxides (1998)

Abstract Powder X‐ray diffraction and cryo electron diffraction techniques supported by computer simulations were used to determine the secondary structures of the series of heteropoly acid (HPA) compounds Cs x H 4‐ x PVMo 11 O 40 · n H 2 O (0≤ x ≤4). The structures of the caesium salts (2≤ x ≤4) are simple cubic with space group Pn3m. The free acid exhibits a triclinic lattice (P−1) for the majority of all crystals. A small fraction of thin crystals was detected with simple cubic structure (Pn3m). Computer simulations of the X‐ray diffraction patterns suggested that the structure of Cs 2 H 2 PVMo 11 O 40 ·5H 2 O contains defects in the cation lattice. The caesium ion occupancy is 2/3. [H 5 O 2 ]+‐groups occupy 1/3 of the cation positions. The diffraction pattern of Cs 4 PVMo 11 O 40 ·5H 2 O could be simulated when only 3/4 of the anion positions are occupied. Cs 3 HPVMo 11 O 40 ·7H 2 O crystallises in a simple cubic lattice without any defects. The secondary structures of the investigated heteropoly salts can, therefore, be described by a single structure with variable site occupations, with the exception of Cs 3 HPVMo 11 O 40 ·7H 2 O (caesium ion occupancy of 1 and poly anion occupancy of 1). All salts belong to one phase with large stoichiometric variations. A mixture of acid and caesium salt, with the acid epitactly grown on the salts, an intergrowth‐structure witii varying caesium ion content, mixed crystals as well as the coexistence of a nanocrystalline X‐ray‐invisible form of free acid besides caesium salt could be excluded for the partly neutralised materials. Selected physico‐chemical properties of the HPA compounds, which depend on the caesium ion content, will be rationalised widi the knowledge of the secondary structures.
Abstractive Tabular Dataset Summarization via Knowledge Base Semantic\n Embeddings (2018)

This paper describes an abstractive summarization method for tabular data\nwhich employs a knowledge base semantic embedding to generate the summary.\nAssuming the dataset contains descriptive text in headers, columns and/or some\naugmenting metadata, the system employs the embedding to recommend a\nsubject/type for each text segment. Recommendations are aggregated into a small\ncollection of super types considered to be descriptive of the dataset by\nexploiting the hierarchy of types in a pre-specified ontology. Using February\n2015 Wikipedia as the knowledge base, and a corresponding DBpedia ontology as\ntypes, we present experimental results on open data taken from several\nsources--OpenML, CKAN and data.world--to illustrate the effectiveness of the\napproach.\n
Performance Evaluation of Series-Compensated IPT Systems for Transcutaneous Energy Transfer (2018)

Today's implantable mechanical circulatory support devices, such as left ventricular assist devices, still rely on a percutaneous driveline, which is a frequent cause of severe infections and which reduces the quality of life for the patients. Inductive power transfer (IPT) is therefore a promising technology to replace the driveline and, hence, reducing the likelihood of an infection. This paper focuses on the series-series compensated IPT system and provides an in-depth comparison of two operating modes, i.e., the operation at resonance and the operation above resonance, and highlights the advantages and disadvantages with respect to the requirements set by the application at hand. In addition, the paper presents the design and the realization of a fully functional transcutaneous energy transfer (TET) implant hardware prototype, which includes the IPT front-end, the control circuit, the backup battery and its charging converter, as well as the communication electronics in a boxed volume of only 10.3 cl. The experimental verification shows that overall dc-dc efficiencies of up to 90% can be achieved for both operating modes when transmitting 25-30 W from the external battery to the implant backup battery, each having a nominal voltage of 14.8 V, using TET coils with 70 mm diameter and 10 mm coil separation distance.
Opérateurs de morphologie mathématique et exploitation des courbures discrètes pour la détection de tumeurs dans un modèle rénal (2014)

National audience
Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma (2004)

KIT and PDGFRA are receptor tyrosine kinases that can be specifically inactivated by small-molecule tyrosine kinase inhibitors, notably imatinib mesylate. In ovarian carcinoma, expression of KIT and PDGFRA protein has been documented, but the frequency and the molecular background of expression are poorly known. We analysed the expression of KIT and PDGFRA by immunohistochemistry in 522 serous ovarian carcinomas, and mutations of KIT and PDGFRA by denaturing high-performance liquid chromatographyin 125 and 187 serous ovarian carcinomas, respectively. No mutations of KIT or PDGFRA were detected. KIT expression was detected in 12% of carcinomas: low expression in 10% and high expression in 2% of cases. Using normal serous epithelium as a reference, decreased PDGFRA expression was detected in 12% and increased expression in 13% of carcinomas. Both KIT and PDGFRA expression were associated with high tumour grade, high proliferation index and poor patient outcome. By fluorescence in situ hybridisation, no KIT amplification was found in carcinomas with high KIT expression, but two cases showed a relative gain of chromosome 4. In conclusion, no mutations of KIT or PDGFRA were found, but a subset of serous ovarian carcinoma showed overexpression of the proteins, which was associated with aggressive tumour characteristics.
Supplementary Figure 1 from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface (2023)

&lt;p&gt;PDF file - 1308K, Production and analysis of the SD1-based recombinant immunotoxin.&lt;/p&gt;
Synthesis of Molybdenum(VI) Monoimido Alkyl and Alkylidene Complexes (2005)

In this paper we report the synthesis of several new Mo(NR)Cl4(THF) species (R = C6F5, 3,5-(CF3)2C6H3, 1-adamantyl, CPh3, and 2,6-i-Pr2C6H3) via the treatment of MoCl4(THF)2 with azides and their reactions with neopentyl reagents. Addition of Mo(NR)Cl4(THF) complexes in toluene to a cold solution of NpMgCl in ether gave Mo(NR)Np3Cl species (R = C6F5, 3,5-(CF3)2C6H3, Ad, Ph3C, and 2,6-i-Pr2C6H3 (Ar); Np = CH2-t-Bu) in poor (35%) to modest (51%) yields. Heating Mo(NAr)Np3Cl in C6D6 to 50 °C results in α-hydrogen abstraction to give neopentane and a molecule whose NMR spectra are consistent with it being Mo(NAr)(CH-t-Bu)(CH2-t-Bu)Cl; it decomposed bimolecularly upon attempted isolation. The other Mo(NR)Np3Cl species were found to be more stable than Mo(NAr)Np3Cl, but when they did decompose at elevated temperatures, no neopentylidene complex could be observed. Addition of neopentyllithium to Mo(NR)Np3Cl species (R = Ar, CPh3, or Ad) yielded Mo(NR)(CH-t-Bu)Np2 species, the adamantylimido version of which is unstable toward bimolecular decomposition. Addition of neopentyllithium to Mo(NR)Np3Cl complexes in which R = pentafluorophenyl or 3,5-trifluoromethylphenyl led to intractable mixtures. Addition of 1 equiv of 2,6-diisopropylphenol, 2,6-dimethylphenol, or 3,5-(2,4,6-i-Pr3C6H2)2C6H3OH (HIPTOH) to Mo(NCPh3)(CH-t-Bu)Np2 led to formation of Mo(NCPh3)(CH-t-Bu)Np(OR) species, while treatment of Mo(NCPh3)(CH-t-Bu)2(CH2-t-Bu) with C6F5OH gave Mo(NCPh3)Np3(OC6F5). The three monophenoxide neopentylidene complexes showed poor to moderate metathesis activity for ring-closing a small selection of substrates. X-ray studies were completed for Mo[N-3,5-(CF3)2C6H3]Cl4(THF), Mo[N-3,5-(CF3)2C6H3]Np3Cl, Mo(NCPh3)Np3Cl, and Mo(NCPh3)(CH-t-Bu)(CH2-t-Bu)(OHIPT).
Abstract #5373: Glycoproteomic characterization of human gamma-glutamyl transpeptidase (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

The timely and accurate diagnosis of liver and pancreatic cancer is critical for maximizing the efficacy of therapeutic intervention. Currently, there are no reliable clinical screening tests for these two high-mortality forms of cancer. A primary obstacle to the development of early detection assays is the considerable overlap in symptoms and serum composition between malignant and non-malignant forms of liver and pancreatic diseases. Both hepatocellular carcinoma and pancreatic adenocarcinoma are associated with elevated levels of the glycoprotein gamma-glutamyl transpeptidase (GGT). While elevated serum GGT levels are not specific to malignant forms of liver and pancreatic disease, an accumulating body of data has provided evidence for the existence of distinct tissue- and tumor-specific glycosylation patterns on GGT, which may serve as reporters for enhancing the sensitivity and specificity of diagnosis. To better understand how these tumor-specific glycosylation changes are manifested, we have investigated the structural composition and site occupancy of the glycan moieties on GGT from normal human liver and pancreatic tissue. Using mass spectrometry, we have characterized all six N -linked glycosylation sites on the large subunit of GGT expressed in the normal human tissues. Moreover, high-resolution glycomic analyses on these samples have demonstrated that GGT serves as a faithful reporter protein for recapitulating the tissue-specific glycosylation patterns observed within the organ. These results are being utilized for analytical comparisons against GGT isolated from tumor tissue samples with the objective of identifying novel keystone glycan epitopes present on the high levels of circulating GGT in the serum of patients with pancreatic and liver cancer. This work will generate new insights into tumor-specific post-translational modification regimes and broaden our understanding of the efficacy of altered glycosylation patterns on serum glycoproteins as reliable biomarkers for cancer.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5373.