gebhart/patrepeval huggingface dataset:
Adaptive Techniques for Large Space Apertures. (1980)

Two missions which utilize large space apertures were considered on the program. These were the space-based radar mission (SBR) and the space-based millimeter-wave radiometer mission (MWR). The greater part of the effort was spent on the radar mission. The intent of the program was to investigate reflector-based alternates to the space-fed phased array system that is the current baseline for the space-based radar program. The three major tasks on the program were Task 1, Concept Development/Assessment; Task 2, Performance Analysis, Selected Approach; and Task 3, Specific Mission Designs. The adaptive techniques of interest were those that might be required to compensate for surface irregularities in the large, space-deployable reflectors that would be required for these missions. This and other system requirements were considered in selecting an antenna system for each mission. (Author)
Supplementary Figure 8 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma (2023)

&lt;p&gt;PDF file - 190KB, Cytokine production by multiplex assay in plasma from patients F5-12 and F5-14 to study the potential development of a cytokine storm.&lt;/p&gt;
Polymethacrylate based microparticulates of insulin for oral delivery, part II: solid state characterization. (2008)

The objectives of the present study were (A) to characterize insulin microparticles prepared by the coprecipitation process by size exclusion chromatography, differential scanning calorimetry, fourier-transform IR spectroscopy, and powder X-ray diffractometry, and (B) to study the solid state conformation of insulin before and after entrapment in the polymeric carrier. Microparticles were prepared by dissolving insulin in 0.01 N HCI and alcohol USP to get a final concentration of 32% v/v. Eudragit L100, a representative polymethyacrylate polymer, was then dissolved in this solution which was transferred to a beaker containing cold water with homogenization to obtain microparticulates. Insulin powder, microcapsules, and a physical mixture of insulin and Eudragit L100 were then analyzed by SEC-HPLC, DSC, FTIR, and XRD to observe changes in protein conformation as result of the manufacturing process. While DSC, XRD and FTIR results were of limited value due to limits of instrument sensitivity, size exclusion chromatography data indicated that higher order aggregates were not formed during microcapsule formation. It was concluded that formulating insulin into microparticles by the coprecipitation process is an attractive and stable method for protein delivery and might be suitable for oral delivery of insulin.
Results of nerve grafting for injuries of the axillary and suprascapular nerves (1997)

We report the results in 33 patients who had nerve grafting of the axillary or the suprascapular nerve or of both. There were 32 men and one woman; their mean age was 21 years and the average interval between injury and operation was three months. At a mean follow-up of 27 months, the deltoid had recovered to M3 or better in 23 of 30 patients (77%) and the infraspinatus in 18 of 25 patients (72%). Shoulder elevation had reached 120 degrees or more in 27 patients (82%), with external rotation of 30 degrees or more in 27 (82%). Twenty-six patients (79%) could reach to the top of their head with their hand. Recovery of muscle strength, range of movement and shoulder function were satisfactory when surgery was performed within four months of the injury. Early exploration and nerve grafting can lead to a good functional recovery, but thorough exploration and careful repair of both nerves are essential.
Actionneurs linéaires directs et indirects : performances limites (2004)

National audience
Shear band formation and ductility in bulk metallic glass (2005)

Abstract The variations in the chemical compositions of the metallic glasses reported in the literature, as well as the overall lack of experimental data concerning the inhomogeneous deformation behaviour of metallic glass, make the evaluation of the effects of shear band/fracture behaviour on the mechanical properties of metallic glasses difficult. Isolating the effect of local shear band formation on bulk inhomogeneous flow would appear to be a first step in approaching this problem. The mechanical behaviour of Vitreloy metallic glass at room temperature and at various strain rates in tension and compression was investigated. The formation of multiple shear bands was observed at high strain rates. An increase in strain rate leads to enhanced ductility in tension and compression. Some aspects of the deformation processes in tension and compression are discussed. Acknowledgement The authors would like to acknowledge the Office for Naval Research for financial support under ONR grant N00014-03-1-0149.
High-power LPP-EUV source with long collector mirror lifetime for semiconductor high-volume manufacturing (2019)

We have been developing CO2-Sn-LPP EUV light source which is the most promising solution as the 13.5nm high power light source for HVM EUVL. Unique and original technologies such as; combination of pulsed CO2 laser and Sn droplets, dual wavelength laser pulses shooting and mitigation with magnetic field have been developed in Gigaphoton Inc.. We have developed first practical source for HVM; “GL200E” 1) in 2014. We have proved high average power CO2 laser more than 20kW at output power cooperate with Mitsubishi electric cooperation2). Pilot#1 is up running and its demonstrates HVM capability; EUV power recorded at111W average (117W in burst stabilized, 95% duty) with 5% conversion efficiency for 22hours operation in October 20163). Availability is potentially achievable at 89% (2weeks average), also superior magnetic mitigation has demonstrated promising mirror degradation rate (= 0.5%/Gp) above 100W level operation with dummy mirror test.4). Recently we have demonstrated actual collector mirror reflectivity degradation rate is less than -0.4%/Gp by using real collector mirror around 100W ( at I/F clean ) in burst power during 30 Billion pulses operation. We will report latest data 125W average operation with actual collector mirror at conference. Reference 1) Hakaru Mizoguchi, et. al.: “Sub-hundred Watt operation demonstration of HVM LPP-EUV source”, Proc. SPIE 9048, (2014) 2) Yoichi Tanino et.al.:” A Driver CO2 Laser Using Transverse-flow CO2 Laser Amplifiers”, EUV Symposium 2013, ( Oct.6-10.2013, Toyama) 3) Hakaru Mizoguchi et al.:” Performance of 250W High Power HVM LPP-EUV Source”, Proc. SPIE 10143, Extreme Ultraviolet (EUV) Lithography VIII (2017) 4) Hakaru Mizoguchi, et al: ” High Power HVM LPP-EUV Source with Long Collector Mirror Lifetime”, EUVL Workshop 2017, (Berkley, 12-15, June, 2017)
Studying neural responses for multi-component economic choices in human and non-human primates using concept-based behavioral choice experiments (2023)

Realistic, everyday rewards contain multiple components, such as taste and size. However, our reward valuations and the associated neural reward signals are single dimensional (vector to scalar transformation). Here, we present a protocol to identify these single-dimensional neural responses for multi-component choice options in humans and monkeys using concept-based behavioral choice experiments. We describe the use of stringent economic concepts to develop and implement behavioral tasks. We detail regional neuroimaging in humans and fine-grained neurophysiology in monkeys and describe approaches for data analysis. For complete details on the use and execution of this protocol, please refer to our work on humans Seak et al.<sup>1</sup> and Pastor-Bernier et al.<sup>2</sup> and monkeys Pastor-Bernier et al. <sup>3</sup>, Pastor-Bernier et al.<sup>4</sup>, and Pastor-Bernier et al.<sup>5</sup>.
Shaping long-lived electron wavepackets for customizable optical spectra (2019)

Electrons in atoms and molecules are versatile physical systems allowing a vast range of light–matter interactions. Spontaneous emission, which appears in a wide variety of applications, depends crucially on the bound electron energy levels. The discrete nature of these electron energy levels and the ionization threshold constrain the energy scale of all light–matter interactions involving bound electrons. To bypass these constraints, we take ideas from optical and electronic beam shaping and propose creating new electron states as superpositions of extended states above the ionization threshold. We show that such superpositions enable the control of spontaneous emission with tunable spectra in the eV–keV range. We find that the specific shaping lengthens the diffraction and radiative lifetimes of the wavepackets in exchange for increasing their spatial spreads. Our approach could have applications toward developing novel kinds of light emitters at hard-to-access spectral ranges.
VPD-DC-TXRF for Metallic Contamination Analysis of Ge Wafers (2005)

Ge substrates are recently being reconsidered as a candidate material for the replacement of Si substrates in advanced semiconductor devices, due to their enhanced intrinsic mobility [1]. Specifications towards tolerable metallic contamination levels on these substrates are similar as for Si substrates: i.e. a total concentration of critical metals of 5E9 at/cm
Methodological quality and risk‐of‐bias assessments in systematic reviews of treatments for peri‐implantitis (2019)

Due to the lack of head-to-head comparisons conducted in RCTs, review authors need to use other sources of evidence, such as clinical control trials (CCTs), cohort studies (CS), clinical research (CR), and animal studies. The end result is the presentation of low-quality evidence, with high ROB. Several SRs conducted network meta-analysis as an alternative to head-to-head conventional meta-analysis of RCTs. We suggest that the best methods to generate, access, and assess evidence in situations where RCT evidence is lacking should be discussed on an urgent basis.
Photoionization pumped short-wave-length lasers (1988)

Several vacuum ultraviolet lasers excited by the soft x-ray emissions from a laser-produced plasma have been demonstrated. 1 Schemes in xenon and krypton demonstrated by the authors are discussed, and the extension of photoionization-pumped laser systems to shorter wavelengths is considered. It is shown that shorter wavelengths favor the use of ultrashort pulse lasers as excitation sources. A possible system using ultrashort pulse x rays to pump inner-shell-excited atomic states which are rapidly depleted through Auger decay is proposed and the technological requirements for its implementation are examined. Recent advances in laser technology make such schemes technologically feasible using relatively small scale lasers. Our progress in developing the required laser systems and experiments relating to the basic physics of the scheme are discussed.
A hybrid lead iodide perovskite and lead sulfide QD heterojunction solar cell to obtain a panchromatic response (2014)

We report for the first time on co-sensitization between CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub>perovskite and PbS quantum dots (QDs) in a heterojunction solar cell to obtain a panchromatic response from the visible to near IR regions.
Methotrexate therapy of head and neck cancer: improvement in therapeutic index by the use of leucovorin "rescue". (1970)

Twenty-one patients with advanced epidermoid carcinoma of the head and neck were treated with 24-hr infusions of methotrexate followed by leucovorin rescue repeated at 4-day intervals. Thirteen of the 21 patients responded with a greater than 50% reduction of tumor mass and 7 of the 13 sustained a greater than 75% reduction. The median duration of tumor regression was 16 weeks. In general, toxicity was tolerable. The rationale of this regimen and its comparison with other methotrexate schedules is discussed.
Removal of Magnetic Contamination in Drilling Fluids: Effect on Directional Drilling (2020)

Abstract Magnetic debris in a drilling fluid have a significant influence on the ability of the drilling fluid to maintain its function. Down hole logging can suffer from poor signal to noise ratios. Directional drilling in areas close to the magnetic North Pole, such as in the Barents Sea, Northern Canada or Russia can suffer because of magnetic contamination in the drilling fluid. Magnetic particles in the drilling fluid introduce additional errors to the magnetic surveying compared to those normally included in the ellipsoid of uncertainty calculation. On many offshore drilling rigs, there is mounted ditch magnets to remove metallic swarf from the drilling fluid. These magnets normally only remove the coarser swarf. In this project, we use a combination of strong magnets and flow directors to significantly improve the performance of the ditch magnets. This combination, together with proper routines for cleaning the ditch magnets, significantly helps to clean the drilling fluid. Through the combined use of flow directors and ditch magnets, it was possible to extract more than five times as much magnetic contamination from the drilling fluid as normal compared with other proper ditch magnet systems. This is verified by comparing the ditch magnet efficiencies from two drilling rigs drilling ERD wells in the North Sea area. In the paper, it is discussed how the accuracy of directional drilling and well position effected by various interferences can be improved by the use of a drilling fluid with minimal effect to the MWD measurement.
SGD-Net: Efficient Model-Based Deep Learning With Theoretical Guarantees (2021)

Deep unfolding networks have recently gained popularity for solving imaging inverse problems. However, the computational and memory complexity of data-consistency layers within traditional deep unfolding networks scales with the number of measurements, limiting their applicability to large-scale imaging inverse problems. We propose SGD-Net as a new methodology for improving the efficiency of deep unfolding through stochastic approximations of the data-consistency layers. Our theoretical analysis shows that SGD-Net can be trained to approximate batch deep unfolding networks to an arbitrary precision. Our simulations on intensity diffraction tomography and sparse-view computed tomography show that SGD-Net can match the performance of the traditional batch network at a fraction of training and testing complexity.
Pulsed Laser Deposition of HTSC Thallium Films (1990)

Pulsed laser deposition is a technique commonly used to deposit high quality thin films of high temperature superconductors. We discuss the results obtained when this technique is applied to the deposition of Tl-CA-Ba-Cu-O thin films using a frequency doubled Nd:YAG laser operating at 532 nm and an excimer laser operating at 248 nm. Films with onset temperatures of 125 K and zero resistance temperatures of 110 K deposited on (100) oriented MgO from a composite T12Ca2Ba2Cu3Ox target were obtained at both wavelengths upon appropriate post deposition annealing. We will discuss the microstructure and composition as a function of laser wavelength and annealing conditions.
Horizon Scanning: Rise of Planetary Health Genomics and Digital Twins for Pandemic Preparedness (2021)

The Covid-19 pandemic accelerated research and development not only in infectious diseases but also in digital technologies to improve monitoring, forecasting, and intervening on planetary and ecological risks. In the European Commission, the Destination Earth (DestinE) is a current major initiative to develop a digital model of the Earth (a "digital twin") with high precision. Moreover, omics systems science is undergoing digital transformation impacting nearly all dimensions of the field, including real-time phenotype capture to data analytics using machine learning and artificial intelligence, to name but a few emerging frontiers. We discuss the ways in which the current ongoing digital transformation in omics offers synergies with digital twins/DestinE. Importantly, we note here the rise of a new field of scholarship, planetary health genomics. We conclude that digital transformation in public and private sectors, digital twins/DestinE, and their convergence with omics systems science are poised to build robust capacities for pandemic preparedness and resilient societies in the 21st century.
Compact NIR Confocal Imaging Raman Microspectrometer (1999)

Advances in the fields of micro-optics and micro-mechanics are enabling the construction of increasingly miniature optical instruments capable of high-resolution imaging and spectroscopy. Such instruments will be of considerable practical value for a range of in vivo imaging and spectroscopy techniques, where use of traditionally sized optical instrumentation is a barrier preventing access to many sites in the body. In this paper we describe a compact confocal laser scanning microscope and Raman microspectrometer that incorporates a micromechanical scanning mirror in a compact optical design. We present preliminary images and spectra obtained with a prototype instrument (λ=852 nm, N.A.=0.2, 1 μm spot size), and discuss a development path that would employ micro-optical and micromechanical elements in an endoscopically deployed confocal imaging microspectrometer.
System-Level Thermal Performance Optimization for Electronic Module Incorporating Dual-Channel Power Stage For Digital Amplifier (2006)

A detailed numerical study was conducted to model the thermal behavior of a microelectronics module in a custom environment. The system incorporates four 54-lead small outline integrated circuit (SOIC) packages with exposed pads. These packages were coupled to a heat sink at a free convection environment with an external ambient temperature of 25 degC. The system is optimized by choosing the appropriate heat sink for the efficient operation of the device under constant powering, also is used to quantify the thermal impact of each element on the overall thermal performance of the module. The thermal performance for a maximum powering scenario is evaluated, and the peak field-effect transistor (FET) power levels satisfying the thermal budget (150degC) are identified. Several cases were investigated, varying the power levels and the thermal properties of the interfacing pads while maintaining the ambient temperature at 25degC. The peak temperatures for the typical (1.25 W/package) and maximum powering (3.3 W/package) scenarios range from 68degC to 132.5degC, indicating that both designs satisfy the thermal requirements; the corresponding junction-to-ambient thermal resistances (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ja</sub> ) vary from 8.1degC/W to 8.8degC/W. An additional study evaluates two cases with an improved thermal pad with a thermal conductivity of 20 W/mK, replacing the existing pads, which have a thermal conductivity of 1.1 W/mK. This results in a peak temperature drop by 40degC. The corresponding stack-up thermal resistances were calculated for each layer, and indicate that most of the junction-to-ambient thermal resistance came from the thermal pad and heat sink (HS)-to-ambient thermal resistances. These resistances could be further reduced by applying forced convection to cool the system (thus reducing the heat sink-to-ambient thermal resistance), or by replacing the thermal pads with an improved thermal interface material. The temperature of the heat sink base is fairly uniform, indicating a good lateral heat spreading provided by the heat sink. The thermal interaction between the components is minimal, and could be further reduced when adding a better thermal interface between the package and heat sink
Effects of the top-electrode size on the piezoelectric properties (d33 and S) of lead zirconate titanate thin films (2004)

The effects of a decreasing top electrode size on the electric and piezoelectric properties of tetragonal Pb(ZrX,Ti1−X)O3 thin films are investigated. The effective piezoelectric small-signal coefficient d33,eff and the piezoelectric large signal-strain S are measured using a double-beam laser interferometer. Both properties are found to decrease rapidly with decreasing size of the used Pt top electrode for the investigated dimensions of 5mmto100μm edge length (square pads). While the loss of d33,eff is as high as 75%, the influence on the relative permittivity is only small. The source of the pad size effect on the measured piezoelectric properties is found to be the mechanics of the layered structure commonly used for piezoelectric measurements (Pt∕PZT∕Pt∕TiO∕SiO2∕Si), [PZT,Pb(Zrx,Ti1−x)O3] which is verified by finite element simulations.
P499 Efficacy and safety of 2 or 3 vedolizumab intravenous infusions as induction therapy for ulcerative colitis and Crohn’s disease: results from VISIBLE 1 and 2 (2019)

Vedolizumab is a gut-selective, humanised, α4β7 integrin monoclonal antibody approved for intravenous (IV) administration to patients with moderately to severely active ulcerative colitis (UC) or Crohn’s disease (CD). A subcutaneous (SC) formulation is in development as maintenance therapy. Here, we evaluate clinical response to 2 or 3 doses of vedolizumab IV induction therapy in the phase 3 VISIBLE 1 (UC; NCT02611830) and VISIBLE 2 (CD; NCT02611817) vedolizumab SC maintenance trials. In both trials, patients received open-label vedolizumab 300 mg IV induction therapy at Weeks 0 and 2. At Week 6, clinical responders were randomised into the SC maintenance phase and nonresponders were given a third IV infusion and reassessed at Week 14. Clinical response in UC was assessed at Week 6 as a ≥3-point and ≥30% decrease in complete Mayo score from Week 0 (Baseline) and at Week 14 as a ≥2-point and ≥25% decrease in partial Mayo score from Week 0, together with a rectal bleeding subscore decrease ≥1 point or absolute subscore ≤1 point at both time points. Clinical response for CD was a >70-point decrease in CD Activity Index score from Week 0. Safety of vedolizumab IV induction was assessed. The VISIBLE 1 trial has been completed, whereas VISIBLE 2 is currently ongoing (efficacy data only available as captured by an interactive voice response system). Among the 383 (UC) and 644 (CD) patients who received open-label vedolizumab induction, 56.1% (106/225) with UC and 63.7% (410/644) with CD had a clinical response at Week 6 after 2 vedolizumab IV infusions. Among patients who received a third induction infusion, clinical response rates were 79.7% (114/143) in UC and 63.2% (122/193) in CD. Overall, 86.2% (330/383) of UC patients and 82.6% (532/644) of CD patients achieved a clinical response after 2 or 3 vedolizumab IV infusions. In VISIBLE 1, treatment-emergent adverse events (TEAEs, 62.9% of patients; 17% treatment-related) and serious TEAEs (10.4% of patients; 0.5% treatment-related) were consistent with prior studies and there were no deaths. Adverse events (30.0%) and lack of efficacy (30.0%) were the main reasons for discontinuation. Vedolizumab IV induced a clinical response after 2 infusions in more than half of both UC and CD patients. Patients failing to respond after 2 infusions appeared to benefit from a third infusion and responses were achieved in the vast majority of patients overall. The safety/tolerability profile of vedolizumab IV induction was consistent with previous reports.
The relationship between extension of the metatarsophalangeal joint and sprint time for 100 m Olympic athletes (2005)

Selected kinematic variables of the foot segments and the metatarsophalangeal (MTP) joint were investigated in relation to sprinting performance among 100 m sprint athletes at the 2000 Summer Olympic Games. It was hypothesized that the kinematics of the MTP joint, and forefoot and rearfoot segments, are related to sprint performance for both male and female athletes. Kinematic sagittal plane data were collected using two digital video cameras recording at 120 fields per second. It was determined that faster male sprinters experienced higher maximal rates of MTP extension, and faster female sprinters touch down with higher posterior sole angles and take off with lower posterior sole angles.