gebhart/patrepeval huggingface dataset:
An expedient synthesis of homophthalimides (2002)

The six-membered heterocyclic subunit of homophthalimides can be obtained by a direct, hitherto unprecedented, radical cyclisation onto an aromatic ring starting from a xanthate precursor.
Mono- versus Bidentate Ligands in Rhodium-Catalyzed Asymmetric Hydrogenation. A Comparative Rate Study (2003)

Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.
Dendritic Cell Regulation of Carbon Tetrachloride–Induced Murine Liver Fibrosis Regression (2011)

Taken together, these results suggest that DCs increase fibrosis regression and that the effect is correlated with their production of MMP-9. The results also suggest that Flt3L treatment during fibrosis resolution merits evaluation to accelerate regression of advanced liver fibrosis.
EU FP7 INFSO-ICT-247223 ARTIST4G, D3.1 Definitions and Architecture requirements for supporting Advanced Relay concepts (2010)

The following document addresses the questions received from WP4 and presents the architecture requirements and targets that need to be considered by WP4 in order to support advanced relays in future wireless networks.
An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer (2017)

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identification of a common transcriptional signature across mutant KRAS cancers of distinct tissue origin that includes the transcription factor FOSL1. High FOSL1 expression identifies mutant KRAS lung and pancreatic cancer patients with the worst survival outcome. Furthermore, FOSL1 genetic inhibition is detrimental to both KRAS-driven tumour types. Mechanistically, FOSL1 links the KRAS oncogene to components of the mitotic machinery, a pathway previously postulated to function orthogonally to oncogenic KRAS. FOSL1 targets include AURKA, whose inhibition impairs viability of mutant KRAS cells. Lastly, combination of AURKA and MEK inhibitors induces a deleterious effect on mutant KRAS cells. Our findings unveil KRAS downstream effectors that provide opportunities to treat KRAS-driven cancers.
177Lu-3BP-227 for Neurotensin Receptor 1–Targeted Therapy of Metastatic Pancreatic Adenocarcinoma: First Clinical Results (2017)

Neurotensin receptor 1 (NTR1) is overexpressed in ductal pancreatic adenocarcinoma, which is still one of the deadliest cancers, with a very poor prognosis. Eligible patients were offered salvage radiopharmaceutical therapy with the novel NTR1 antagonist <sup>177</sup>Lu-3BP-227. <b>Methods:</b> Six patients with confirmed ductal pancreatic adenocarcinoma who had exhausted all other treatment options received <sup>177</sup>Lu-3BP-227 for evaluation of NTR1 expression in vivo. Three patients received treatment activities of 5.1-7.5 GBq. <b>Results:</b> Administration of <sup>177</sup>Lu-3BP-227 was well tolerated by all patients. The kidneys were identified as the dose-limiting organ. The most severe adverse event was reversible grade 2 anemia. One patient achieved a partial response and experienced significant improvement of symptoms and quality of life. This patient survived 13 mo from diagnosis and 11 mo from the start of <sup>177</sup>Lu-3BP-227 therapy. <b>Conclusion:</b> This initial report provides clinical evidence of the feasibility of treatment of ductal pancreatic adenocarcinoma using <sup>177</sup>Lu-3BP-227.
Wax-wetting sponges for oil droplets recovery from frigid waters (2021)

Energy-efficient recovery of oil droplets from ice-cold water, such as oil sands tailings, marine, and arctic oil spills, is challenging. In particular, due to paraffin wax crystallization at low temperatures, the crude oil exhibits high viscosity, making it difficult to collect using simple solutions like sponges. Here, we report a wax-wetting sponge designed by conforming to the thermoresponsive microstructure of crude oil droplets. To address paraffin wax crystallization, we designed the sponge by coating a polyester polyurethane substrate with nanosilicon functionalized with paraffin-like octadecyl ligands. The wax-wetting sponge can adsorb oil droplets from wastewater between 5° and 40°C with 90 to 99% removal efficacy for 10 cycles. Also, upon rinsing with heptol, the adsorbed oil is released within seconds. The proposed approach of sponges designed to conform with the temperature-dependent microstructure of the crude oils could enable cold water technologies and improve circular economy metrics in the oil industry.
Current status and optimization of handy compton camera using 3D position-sensitive scintillators (2013)

After the Japanese nuclear disaster in 2011, a large amount of radioactive isotopes was released and still remains a serious problem in Japan. To help identify radiation hotspots and ensure effective decontamination operation, we are developing a novel Compton camera weighing only 1.9 kg and measuring just 14×14×15 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> in size. Despite its compactness, the camera realizes a wide 180° field of vision, Δθ ~ 10°(FWHM) angular resolution, and offers excellent sensitivity that can image a hotspot producing a 5 μSv/h dose at a distance of three meters, every 10 sec. Our key technology using 3D position-sensitive scintillators coupled with thin monolithic MPPC arrays has made this innovation possible for the first time. In this paper, we present the detailed optimization and simulation of the Compton camera currently under production with Hamamatsu Photonics.
Impacts of bottom corrugations on a dense Antarctic outflow: NW Ross Sea (2009)

Prominent seabed corrugations, axially oriented roughly down‐slope, are present along the Antarctic continental slope. We use analytical and numerical model results to assess the potential impact of these corrugations on outflows of dense shelf water that contribute to Antarctic Bottom Water. Down‐slope flow increases with increasing corrugation height and varies with along‐slope wavelength. For parameters appropriate to the northwest Ross Sea, where heights and wavelengths are ∼10–20 m and ∼1.5 km, respectively, we estimate that the corrugations increase the down‐slope transport of dense water, relative to the smooth bottom case, by ∼13%. Corrugations enhance entrainment and reduce along‐slope speed of the dense outflow. Larger amplitude corrugations (∼100 m) observed in other regions may impact outflows elsewhere around the poorly mapped Antarctic continental margin. Our results emphasize the need to consider small‐scale local topography when modeling dense outflows.
Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity (2011)

Virtually all low molecular weight inhibitors of human glutamate carboxypeptidase II (GCPII) are highly polar compounds that have limited use in settings where more lipophilic molecules are desired. Here we report the identification and characterization of GCPII inhibitors with enhanced liphophilicity that are derived from a series of newly identified dipeptidic GCPII substrates featuring nonpolar aliphatic side chains at the C-terminus. To analyze the interactions governing the substrate recognition by GCPII, we determined crystal structures of the inactive GCPII(E424A) mutant in complex with selected dipeptides and complemented the structural data with quantum mechanics/molecular mechanics calculations. Results reveal the importance of nonpolar interactions governing GCPII affinity toward novel substrates as well as formerly unnoticed plasticity of the S1' specificity pocket. On the basis of those data, we designed, synthesized, and evaluated a series of novel GCPII inhibitors with enhanced lipophilicity, with the best candidates having low nanomolar inhibition constants and clogD > -0.3. Our findings offer new insights into the design of more lipophilic inhibitors targeting GCPII.
Editor’s Choice-Clinical impact of delirium and antipsychotic therapy: 10-Year experience from a referral coronary care unit (2015)

In patients admitted to the CCU, delirium was associated with an increase in both in-hospital and one-year mortality. Low doses of haloperidol and quetiapine appeared to be safe, without an increase in risk of sudden cardiac death, in-hospital mortality, or one-year mortality in carefully monitored patients.
Optimization of Computational Resources for MIMO Detection (2011)

For the past decades, the demand in transferring large amounts of data rapidly and reliably has been increasing drastically. One of the more promising techniques that can provide the desired performance is the multiple-input multiple-output (MIMO) technology where multiple antennas are placed at both the transmitting and receiving side of the communication link. One major implementation difficulty of the MIMO technology is the signal separation (detection) problem at the receiving side of the MIMO link. This is due to the fact that the transmitted signals interfere with each other and that separating them can be very difficult if the MIMO channel conditions are not beneficial, i.e., the channel is not well-conditioned. For well-conditioned channels, low-complexity detection methods are often sufficiently accurate. In such cases, performing computationally very expensive optimal detection would be a waste of computational power. This said, for MIMO detection in a coded system, there is always a trade-off between performance and complexity. The fundamental question is, can we save computational resources by performing optimal detection only when it is needed, and something simpler when it is not? This is the question that this thesis aims to answer. In doing so, we present a general framework for adaptively allocating computational resources to different (“simple” and“difficult”) detection problems. This general framework is applicable to any MIMO detector and scenario of choice, and it is exemplified using one particular detection method for which specific allocation techniques are developed and evaluated.
Photorelease of a metal-binding pharmacophore from a Ru(ii) polypyridine complex (2021)

The adoption of compounds that target metalloenzymes comprises a relatively low (<5%) percentage of all FDA approved therapeutics. Metalloenzyme inhibitors typically coordinate to the active site metal ions and therefore contain ligands with charged or highly polar functional groups. While these groups may generate highly water-soluble compounds, this functionalization can also limit their pharmacological properties. To overcome this drawback, drug candidates can be formulated as prodrugs. While a variety of protecting groups have been developed, increasing efforts have been devoted towards the use of caging groups that can be removed upon exposure to light to provide spatial and temporal control over the treatment. Among these, the application of Ru(ii) polypyridine complexes is receiving increased attention based on their attractive biological and photophysical properties. Herein, a conjugate consisting of a metalloenzyme inhibitor and a Ru(ii) polypyridine complex as a photo-cage is presented. The conjugate was designed using density functional theory calculations and docking studies. The conjugate is stable in an aqueous solution, but irradiation of the complex with 450 nm light releases the inhibitor within several minutes. As a model system, the biochemical properties were investigated against the endonucleolytic active site of the influenza virus. While showing no inhibition in the dark in an in vitro assay, the conjugate generated inhibition upon light exposure at 450 nm, demonstrating the ability to liberate the metalloenzyme inhibitor. The presented inhibitor-Ru(ii) polypyridine conjugate is an example of computationally-guided drug design for light-activated drug release and may help reveal new avenues for the prodrugging of metalloenzyme inhibitors.
Diagnosis of lung diseases based on proteomic analysis of exhaled breath condensate (2017)

<b>Objective:</b> a comparative study of the protein spectrum of exhaled breath condensate (EBC) in healthy volunteers and patients with COPD, pneumonia and NSCLC, as well as to assess the possibility of using proteomic analysis of EBC for the diagnosis and differential diagnosis of these diseases. <b>Materials and Methods:</b> We examined 18 patients with COPD, 13 - with community-acquired pneumonia, 26 - with NSCLC and 24 healthy non-smoking volunteers. EBC was collected using ECoScreen. EBC-samples lyophilized, hydrolyzed and analyzed by HPLC and tandem mass spectrometry. <b>Results:</b> Proteomic analysis of EBC four groups of donors identified more than 300 different proteins, most of them were cytoskeletal keratins (CK) type I and II. The content of CKs (5, 6, 14) in the EBC samples of NSCLC patients was significantly higher than in healthy volunteers. Dermcidin, cytoplasmic actin, immunoglobulin-α-kininogen, serum albumin, Zn-α2-glycoprotein were identified in EBC healthy volunteers and patients with COPD and pneumonia. The high concentration of peroxiredoxin in EBC of COPD refers to a pronounced oxidative stress. The high levels of acute phase proteins of inflammation and hypoxia (annexins A1 and A2, HSP90B, cystatins M and B, collagen and histones fragments) were detected in EBC samples of patients with pneumonia. Also α- и β-subunit of hemoglobin, NUCKS, POTEE, high mobility group protein (HMG-I/HMG-Y) and lactoferrin were identified in EBC of patients with NSCLC. <b>Conclusions:</b> We found that samples of EBC groups of healthy nonsmokers, patients with COPD, pneumonia and NSCLC have a characteristic protein spectrum. Most of the identified proteins could be offered as a panel for the diagnosis of these diseases.
Publishing Math Lecture Notes as Linked Data (2010)

We mark up a corpus of LaTeX lecture notes semantically and expose them as Linked Data in XHTML+MathML+RDFa. Our application makes the resulting documents interactively browsable for students. Our ontology helps to answer queries from students and lecturers, and paves the path towards an integration of our corpus with external sites.
Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum (2018)

A novel procedure for the production and purification of disulfide-rich recombinant proteins in L. lactis is described.
Experimental investigation of thermo-optic effects in SiC and Si photonic crystal nanocavities (2011)

We experimentally investigate and compare the thermo-optic effects of silicon carbide (SiC) and silicon (Si) photonic crystal nanocavities on their resonant wavelengths over a temperature range of 25 °C to nearly 200 °C by using a laser source with a wavelength close to the telecommunication wavelength range of 1550 nm. The measured results clearly show that the shift in the resonant wavelength of the SiC cavity is significantly (by a factor of 3) less than that of the Si cavity for the same ambient temperature changes. In addition, the measured results provide direct estimates of the thermo-optic coefficients (dn/dT) for thin SiC and Si as 3.87×10(-5)/°C and 1.60×10(-4)/°C, respectively, for this temperature range.
Equalization enhanced phase noise in Nyquist-spaced superchannel transmission systems using multi-channel digital back-propagation (2015)

Superchannel transmission spaced at the symbol rate, known as Nyquist spacing, has been demonstrated for effectively maximizing the optical communication channel capacity and spectral efficiency. However, the achievable capacity and reach of transmission systems using advanced modulation formats are affected by fibre nonlinearities and equalization enhanced phase noise (EEPN). Fibre nonlinearities can be effectively compensated using digital back-propagation (DBP). However EEPN which arises from the interaction between laser phase noise and dispersion cannot be efficiently mitigated, and can significantly degrade the performance of transmission systems. Here we report the first investigation of the origin and the impact of EEPN in Nyquist-spaced superchannel system, employing electronic dispersion compensation (EDC) and multi-channel DBP (MC-DBP). Analysis was carried out in a Nyquist-spaced 9-channel 32-Gbaud DP-64QAM transmission system. Results confirm that EEPN significantly degrades the performance of all sub-channels of the superchannel system and that the distortions are more severe for the outer sub-channels, both using EDC and MC-DBP. It is also found that the origin of EEPN depends on the relative position between the carrier phase recovery module and the EDC (or MC-DBP) module. Considering EEPN, diverse coding techniques and modulation formats have to be applied for optimizing different sub-channels in superchannel systems.
A Computational Investigation of PPCI-Diffusion Combustion Strategy at Full Load in a Light-Duty GCI Engine (2021)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A two-stage PPCI-diffusion combustion process recently showed good potential to enable clean and fuel-efficient gasoline compression ignition (GCI) combustion at medium-to-high loads. By conducting closed-cycle 3-D CFD combustion analysis, a further step was undertaken in this work to evaluate and optimize the PPCI-diffusion combustion strategy at a full load operating point (2000rpm-23.5 bar IMEPcc) while keeping engine-out NOx below 1 g/kWh.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The light-duty GCI engine used in this investigation featured a custom-designed piston bowl geometry at a 17.0 compression ratio (CR), a high pressure diesel fuel injection system, and advanced single-stage turbocharging. A split fuel injection strategy was used to enable the two-stage PPCI-diffusion combustion process.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;First, the injector spray pattern and swirl ratio effects were evaluated. In-cylinder air utilization and the PPCI-diffusion combustion process were notably influenced by the closed-cycle combustion system design. Among the different spray patterns at a swirl ratio of 0, the one with 120° spray inclusion angle, 8-hole, and 1.5 times total nozzle area (TNA) was favored due to enhanced late-stage fuel-air mixing and more rapid diffusion combustion. In the second step, a fuel injection strategy optimization campaign was performed through a space-filling Design of Experiments (DoE) approach. Overall, the optimized injector spray pattern and the optimized fuel injection strategy together were predicted to produce 5.1% lower ISFC and 50% soot reduction over the baseline. A competitive analysis showed the optimized PPCI-diffusion combustion strategy had the potential to generate substantially lower NOx and soot than a modern light-duty diesel engine at full load.&lt;/div&gt;&lt;/div&gt;
The physics of heat transport in semiconductor lasers (2003)

A first study of thermoelectric and convective effects in lasers is given in addition to Joule and recombination heating. Optimized devices and thermal measurements verifying the theory are presented.
Viscoelastic liquid crystal colloids for the continuous processing of twisted nematic electro-optical cells (2001)

Liquid crystal colloid materials are described based on the liquid crystal (LC) E7 and submicron sized poly(methyl methacrylate-co-divinylbenzene) particles. Application of a thermal treatment to the composite material produces a finely dispersed network of the internally crosslinked polymeric inclusions in the LC-E7. Dynamic rheological measurements on the LC colloids show that the presence of this network imposes pronounced viscoelastic behavior on the material, which may be exploited in the manufacturing of large-area twisted nematic (TN) electro-optical cells via continuous methods as an alternative to the currently available batchwise routes. The electro-optical characteristics of TN cells based on the composite material are approximately comparable to the electro-optical characteristics of a reference cell filled with pure LC E7, which ensures that the largely increased viscoelasticity of the composite does not lead to a degradation of electro-optical properties.
Novel Flexible True Random Number Generator Using Resistive Switching Memory (2021)

This work reports a novel true random number generator (TRNG) using Cu/GO/Pt memristive stack. The volatile regime of the device is utilized to achieve natural stochasticity among the switching cycles. An efficient Arduino-based circuit is built and connected to the memristor to produce the data with low power and cost overheads. National Institute of Standards and Technology (NIST) tests are used to assess the randomness of the generated bits. The produced data passes all NIST tests without the post-processing steps used by most of the true random number generators reported in the literature. Flexibility is a unique feature of the device reported in this work, being fabricated on flexible polymer substrate. This enhances the value of the TRNG and facilitates its deployment in smart wearable devices. This work is considered a great millstone towards efficient flexible secure smart electronics.
Second- or third-line nivolumab (Nivo) versus nivo plus ipilimumab (Ipi) in malignant pleural mesothelioma (MPM) patients: Results of the IFCT-1501 MAPS2 randomized phase II trial. (2017)

LBA8507 Background: To date, no treatment is recommended in MPM pts progressing after 1 st -line pemetrexed-platinum doublet. Disease control rate (DCR) is &lt;30% with all drugs tested in 2 nd -line setting. Preliminary results suggested possible activity of anti-PD-1 mAb in 2 nd /3 rd- line, opposed to single agent anti-CTLA-4 mAb. Therefore anti-PD1 mAb efficacy deserves confirmation, and anti-PD-1 + anti-CTLA-4 combination value is currently unknown in MPM. Methods: In this multicenter randomized non comparative phase 2 trial, eligible pts had age&gt;18, PS 0-1, histologically proven MPM relapsing after 1 or 2 prior lines including pemetrexed/platinum doublet, measurable disease. Randomized pts (1:1) received Nivo 3 mg/kg q2w, or Nivo 3 mg/kg q2w + Ipi 1 mg/kg q6w, until progression or unacceptable toxicity. Primary endpoint was DCR at 12 weeks with a blinded independent central review (BICR). 114 patients were to be randomized (with 108 eligible), with one-step Fleming procedure, H0 P&lt;20% vs H1 P&gt;40%, with 95% power, 5% one-sided a-risk: ≥17 failure-free pts had to be observed at 12 weeks in either arm, to conclude to the activity of the corresponding regimen. Results: From March to August 2016, 125 pts were enrolled in 21 centers. Males: 80%, median age: 71.8 years (range 32.5-88.1), PS 1: 62.4%, epithelioid 83.2%, 1 previous line: 69.6%; 70% of pts received ≥ 3 cycles of either treatment. Twelve weeks-DCR assessed by BICR in the first 108 eligible pts was 42.6% [IC95%: 29.4-55.8%] with Nivo (n=23/54), and 51.9% [38.5-65.2%] with Nivo+Ipi (n=28/54). ORR was 16.7% [6.7%-26.6%] with Nivo (n=9/54), and 25.9% [14.2-37.6%] with Nivo+Ipi (n=14/54). All grade/G3-4 toxicities were slightly increased in the combo arm (86.9%/16.4%) vs Nivo alone (77.8%/9.5%); 3 treatment-related deaths were observed in the combo arm (1 metabolic encephalopathy, 1 fulminant hepatitis, 1 acute renal failure). Full QoL, PFS and OS data will be presented at 2017 ASCO meeting. Conclusions: Both Nivo and Nivo+Ipi arms reached their endpoint in 2 nd /3 rd- line MPM pts, suggesting that immunotherapy may provide new options for these pts. Clinical trial information: NCT02716272.