gebhart/patrepeval huggingface dataset:
Data from Functional Characterization of Filamin A Interacting Protein 1–Like, a Novel Candidate for Antivascular Cancer Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Inhibiting angiogenesis has become a major therapeutic strategy for cancer treatment. To identify common intracellular mediators, we previously analyzed gene expression profiles of endothelial cells after treatment with angiogenesis inhibitors. &lt;i&gt;Filamin A interacting protein 1-like&lt;/i&gt; (&lt;i&gt;FILIP1L&lt;/i&gt;; previously known as &lt;i&gt;down-regulated in ovarian cancer 1&lt;/i&gt;) was identified as one of the genes up-regulated in endothelial cells in response to these inhibitors. However, the expression and function of FILIP1L protein is uncharacterized. Here, we provide the first description of the expression and specific subcellular localization of FILIP1L protein in human tissue. Overexpression of FILIP1L resulted in inhibition of cell proliferation and migration and increased apoptosis. In addition, overexpression of FILIP1L truncation mutants showed differential antiproliferative activity. A COOH terminal truncation mutant (FILIP1LΔC103) was more potent than wild-type FILIP1L in mediating this activity. Targeted expression of FILIP1LΔC103 in tumor vasculature inhibited tumor growth &lt;i&gt;in vivo&lt;/i&gt;. Overall, these findings suggest that the novel protein FILIP1L may be an important mediator of the effects of angiogenesis inhibitors and that FILIP1L has the potential to be an antivascular reagent for cancer therapy. [Cancer Res 2008;68(18):7332–41]&lt;/p&gt;&lt;/div&gt;
Coupling of Two Multistep Catalytic Cycles for the One‐Pot Synthesis of Propargylamines from Alcohols and Primary Amines on a Nanoparticulated Gold Catalyst (2012)

A one-pot reaction was performed with a nanoparticulated gold catalyst. A secondary amine is formed through N-monoalkylation of a primary amine with an alcohol by a borrowing hydrogen methodology in a three-step reaction. The secondary amine formed enters into a second A(3)-coupling cycle to give propargylamines. The multistep reaction requires a gold species formed and stabilized on a ceria surface.
Effect of silage type and energy concentration onconjugated linoleic acid (CLA) in milk fat fromdairy cows (2004)

40 lactating cows were fed either clovergrass or maize silage and a low or high dietary energy concentration in a 2 2 factorial design. The maize silage diets rich in starch and linoleic acid resulted in a higher content of c9t11 and t10c12 CLA in milk fat than the grass silage diets. A high energy concentration plus maize silage led to a pronounced shift in the biohydrogenation pathway of linoleic acid, the highest t10c12 CLA content and lowest milk fat percentage. Energy concentration had no effect on milk fat CLA content or milk fat percentage in grass silage fed cows.
Mechanical analysis andin situstructural and morphological evaluation of Ni–Sn alloy anodes for Li ion batteries (2007)

In lithium ion batteries, it has previously been shown that Ni–Sn thin film anodes containing 62 at.% Sn show outstanding electrochemical characteristics, e.g. good capacity and endurance, during charge–discharge cycling. However, their mechanical response, which is likely related to their lifetime in service, has so far received relatively little attention. To address this, nanoindentation and nanowear techniques have been used to characterize the mechanical properties of thin Ni–Sn films electrodeposited on a copper substrate. In situ morphology analysis together with in situ stress measurement has been performed to assess the properties of Ni–Sn thin film anodes during electrochemical cycling. The change in mechanical properties, residual stress and fracture behaviour of the anodes is related to the phase changes which occur during charge–discharge cycling. The correlation between the mechanical properties of the films and their charge–discharge characteristics serves as a useful indicator for optimized design of a Sn-based intermetallic anode film for lithium ion secondary batteries.
Uptake of benzo(a)pyrene in gizzard shad: The relative roles of water ventilation and sediment ingestion (1995)

The objective of this study was to determine whether sediment ingestion or water ventilation was the primary route of uptake of benzo(a)pyrene (BaP) into the tissues of the detritivorous fish, gizzard shad (Dorosoma cepedianum). Two experiments were conducted in which fish were exposed to sediments spiked with 1 {micro}g/g BaP. In the first experiment, fish were prevented from feeding on the sediment by surgical ligation of the esophagus. Water flow in the tank exceeded 12 turnovers per day, and there was no detectable concentration of BaP in the fish after 22 days of exposure. The second experiment duplicated the first, with the exception that 20 nonligated fish were added to the aquaria along with 20 ligated fish, and the semipermeable membrane devices were used to quantify the bioavailability of BaP. The nonligated fish roiled the water as they fed, forcing the ligated fish to ventilate turbid water. Fish were collected 4, 8, 15 and 22 days after initiation of the experiment. Fourteen of the twenty nonligated fish had detectable levels of BaP in their tissues. In these fish, concentrations of BaP exceeded 0.01 {micro}g/g after 4 days of exposure, but did not significantly change for the remainder of the experiment.more » Only three of the ligated fish had detectable concentrations of BaP in their tissues. Sediment ingestion appears to be the primary route of entry of BaP into gizzard shad, while ventilation appears to be a minor route of entry even when the fish ventilate turbid water.« less
<title>Planar formation of 3D highly parallel optical fan-out interconnects for wafer scale optical clock signal distribution</title> (1994)

In this paper, we present a miniaturized compact 3-D optical fan-out interconnect suitable for wafer scale VLSI multichip module optical clock signal distribution. The demonstrated device employs a thin light-guiding substrate in conjunction with a 2-D optical hologram array. The parallel feature among fan-out beams and the planar compact structure convert the unsolvable three spatial and three angular multiple alignment problem into a single-step 2-D planar one, which greatly enhances the packaging reliability. A new design scheme for minimizing throughput power non-uniformity is presented for the first time. A 25 GHz 1-to-42 highly parallel fan-out interconnect was demonstrated with a signal to noise ratio of 10 dB.
Determination and quantification of sulfadiazine and trimethoprim in swine tissues using liquid chromatography with ultraviolet and mass spectrometric detection (2000)

High-performance liquid chromatographic procedures with ultraviolet detection were developed for the quantitative determination of sulfadiazine (SDA) and trimethoprim (TMP) in swine tissues (kidney, liver, muscle, fat and fat + skin). In addition, high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry was used for the confirmation of the identity of the analytes of interest. Chromatographic separation was achieved on a Spherisorb ODS-2 column (250 x 4.6 mm id, dp 5 microns). The mobile phase for SDA analysis consisted of 1% acetic acid in water-acetonitrile (85 + 15, v/v). For TMP analysis a 80 + 15 + 5 (v/v/v) mixture of 0.25% triethylammonium acetate in water, acetonitrile and methanol was used as the eluent. Sulfamerazine and ormethoprim were used as the internal standards for SDA and TMP analysis, respectively. For the isolation of the compounds of interest from biological samples, a liquid-liquid extraction with acetone and ethyl acetate, followed by a clean-up using a solid-phase extraction column (aminopropyl and benzenesulfonic acid for SDA, benzenesulfonic acid for TMP) was performed. Calibration graphs were prepared for all tissues and linearity was achieved over the concentration ranges tested (50-1000 ng g-1 for SDA, r > or = 0.9979; 25-500 ng g-1 for TMP, r > or = 0.9994). The method was validated at the maximum residue level (MRL, 100 ng g-1 for SDA and 50 ng g-1 for TMP), at half the MRL and at double the MRL for both SDA and TMP. The accuracy and precision (expressed as the within-day repeatability) were found to be within the required ranges for each specific concentration. The quantification limits were 50 ng g-1 for SDA and 25 ng g-1 for TMP. The limits of detection were below one half the MRLs. Both methods were selective for the determination of SDA and TMP. Biological samples (kidney, liver, muscle, fat and fat + skin) from pigs that received a commercial SDA-TMP preparation with the feed for five consecutive days (dose rate: 25 mg SDA and 5 mg TMP kg body weight-1 day-1) were analyzed using the described methods. The quantitative results were used to calculate a withdrawal time (12 days) to reach residue levels below the respective MRLs. This calculation was performed according to the recommendations of the European Agency for the Evaluation of Medicinal Products (EMEA/CVMP/036/95).
Characterization of APD- PIN photodiodes using InAs/InAlGaAs quantum-dot absorption layer (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Umezawa, K. Akahane, A. Kanno, and T. Kawanishi, "Characterization of APD- PIN photodiodes using InAs/InAlGaAs quantum-dot absorption layer," in CLEO: 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper CTh4J.8. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation Reactions (2007)

Schnelle Suche: Druckmikroreaktoren erweitern den Bereich der Reaktionsbedingungen erheblich und beschleunigen den Gas-flüssig-Massentransfer. Heck-Aminocarbonylierungen (siehe Schema) belegen das Potenzial für das schnelle und sichere Durchmustern von Reagentien und Reaktionsbedingungen. Die Amidausbeute steigt mit der Temperatur, und die Selektivität bezüglich der α-Ketoamidbildung (n=2) steigt mit abnehmender Temperatur und zunehmendem Druck.
Analysis of Flaming and Its Applications in CGM (2015)

Nowadays, anybody can easily express their opinion publicly through Consumer Generated Media. Because of this, a phenomenon of flooding criticism on the Internet, called flaming, frequently occurs. Although there are strong demands for flaming management, a service to reduce damage caused by a flaming after one occurs, it is very difficult to properly do so in practice. We are trying to keep the flaming from happening. It is necessary to identify the situation and the remark which are likely to cause flaming for our goal. Concretely, we propose methods to identify a potential tweet which will be a likely candidate of a flaming on Twitter, considering public opinion among Twitter users. Among three categories of flamings, our main focus is Struggles between Conflicting Values (SBCV), which is defined as a remark that forces one's own opinion about a topic on others. Forecasting of this type of flamings is potentially desired since most of its victims are celebrities, who need to care one's own social images. We proceed with a working hypothesis: a SBCV is caused by a gap between the polarity of the remark and that of public opinion. First, we have visualized the process how a remark gets flamed when its content is far from public opinion, by means of our original parameter daily polarity (dp). Second, we have built a highly accurate flaming prediction model with decision tree learning, using cumulative dp as an attribute along with parameters available from Twitter APIs. The experimental result suggests that the hypothesis is correct.
Supplemental Table 1 from Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival (2023)

&lt;p&gt;Correlation between ALT status and ATRX and DAXX protein expression.&lt;/p&gt;
Beam-steerable integrated lens antenna with waveguide feeding system for 71–76/81–86 GHz point-to-point applications (2016)

The paper presents design of an electronically beam-steerable integrated lens antenna for 71-76/81-86 GHz point-to-point applications. The proposed antenna is based on a combination of a waveguide feeding system and a hemielliptical dielectric lens with the diameter of 120 mm. The waveguide feeding system has one WR-12 input port and four electronically switched WR-12 output ports. It is based on SP4T MMIC switch mounted on a PCB with tapered antipodal fin-line waveguide-to-microstrip transitions. The feeding system is connected to an array of four linearly arranged rectangular waveguide feed elements used to effectively illuminate the lens. Measurement results of the fabricated feeding system show that S11 level is below -8 dB in the whole 71-86 GHz frequency band. The average level of S21 in the 71-86 GHz band is about -7 dB with the deviations between four outputs less than ±1 dB and the isolation is greater than 20 dB. The measured gain value of the antenna itself exceeds 38 dBi at the center frequency of the considered frequency band. The half power beamwidth values for all beams are in the range of 1.7-1.9 degrees with the beams overlapping level around -3 dB that provides beam-scanning range over ± 3.4 degrees. High gain values and good beam-steering capabilities allow considering the designed lens antenna as a perspective one for millimeter-wave backhaul applications.
Partial discharge inception voltage of twisted pair samples under long-time repetitive bipolar impulses (2005)

The reliability of inverter-fed motors depends on partial discharge (PD) behavior of stator windings. In this paper we discuss partial discharge inception voltage (PDFV) characteristics of twisted-pair samples under long-time repetitive impulses using optical and electrical PD detection methods. For PDIV measurement, we adopted step-by-step and continuous rise of peak voltage of impulse. The repetitive frequency is 500 Hz. The result suggests that PD can occur even after a long period of time of repetitive impulses. We discuss practical importance of test procedure of PDIV under the special voltage waveforms.
ChemInform Abstract: Methyl 2‐Azido‐3‐O‐benzyl‐2‐deoxy‐α‐D‐mannofuranoside as a Divergent Intermediate for the Synthesis of Polyhydroxylated Piperidines and Pyrrolidines: Synthesis of 2,5‐Dideoxy‐2,5‐imino‐D‐mannitol (2R,5R‐Dihydroxymethyl‐3R,4R‐dihydroxypyrrolidine). (1987)

Abstract The title compound (Va) is synthesized from the carbonate (I) (readily accessible from glucose in several steps) via the intermediates shown in the scheme.
Surface Mesh Density Extraction of Orthopedic Magnetic Resonance Image With Hue Saturation Value Filtering1 (2015)

This research aims to develop methods for automated extraction of geometry and density from magnetic resonance images (MRIs) for building 3D mesh objects containing density data. This paper proposes a novel method for extracting 3D models from MRI and also proposes a new voxel based approach to identify the density of internal tissues based on the intensity of MRI.
Gaussian Variant of Freivalds' Algorithm for Efficient and Reliable Matrix Product Verification (2017)

In this article, we consider the general problem of checking the correctness of matrix multiplication. Given three $n \times n$ matrices $A$, $B$, and $C$, the goal is to verify that $A \times B=C$ without carrying out the computationally costly operations of matrix multiplication and comparing the product $A \times B$ with $C$, term by term. This is especially important when some or all of these matrices are very large, and when the computing environment is prone to soft errors. Here we extend Freivalds' algorithm to a Gaussian Variant of Freivalds' Algorithm (GVFA) by projecting the product $A \times B$ as well as $C$ onto a Gaussian random vector and then comparing the resulting vectors. The computational complexity of GVFA is consistent with that of Freivalds' algorithm, which is $O(n^{2})$. However, unlike Freivalds' algorithm, whose probability of a false positive is $2^{-k}$, where $k$ is the number of iterations. Our theoretical analysis shows that when $A \times B \neq C$, GVFA produces a false positive on set of inputs of measure zero with exact arithmetic. When we introduce round-off error and floating point arithmetic into our analysis, we can show that the larger this error, the higher the probability that GVFA avoids false positives. Moreover, by iterating GVFA $k$ times, the probability of a false positive decreases as $p^k$, where $p$ is a very small value depending on the nature of the fault on the result matrix and the arithmetic system's floating-point precision. Unlike deterministic algorithms, there do not exist any fault patterns that are completely undetectable with GVFA. Thus GVFA can be used to provide efficient fault tolerance in numerical linear algebra, and it can be efficiently implemented on modern computing architectures. In particular, GVFA can be very efficiently implemented on architectures with hardware support for fused multiply-add operations.
On the Air - New Signals from first GPS IIF Satellite (2010)

Recent launch of the first GPS Block IIF satellite brought new GNSS signals on the air. Researchers at the German Aerospace Center and Stanford University provide an early analysis of the signals' performance.
Theory of Electrocaloric Effect in a Shape-Changing Container: Gas in a Nanotube (2014)

Driven by applied voltage or Ohmic heating, bistable nanotubes filled with gas can transform between expanded and collapsed configurations and by doing so convert energy between mechanical, electrical, and thermal forms. The electrocaloric response, a reversible change of temperature in response to applied voltage, combines the advantages of a working fluid with the lack of internal interfaces characteristic of robust solid-state thermoelectric devices. Such devices could be constructed from any conductive two-dimensional atomically thin material wrapped into an appropriate geometry.
Scheduling Steel Production using Mixed-Integer Programming and Constraint Programming (2007)

We present an overview of a system we have developed for generating short-term production schedules for a large steel manufacturer. We have developed a decomposition based approach which uses mixed-integer programming to generate a plan for production on the downstream casting processes, and constraint programming to generate a schedule upstream of these casting processes, taking into account detailed scheduling constraints and preferences. One drawback to this approach is that downstream production plans can be generated which cannot be scheduled on the upstream processes, since downstream planning does not take into account bottlenecks that may occur when scheduling upstream. We investigate an integration mechanism, which uses constraint programming to build local estimations of upstream capacity utilization, which are used in the integer programming formulation for downstream production planning. We present results illustrating the effectiveness of this approach.
Cationic Lanthanide Complexes of N,N‘-Bis(2-pyridylmethyl)ethylenediamine-N,N‘-diacetic Acid (H2bped) (1997)

A series of monocationic lanthanide complexes containing the ligand N,N'-bis(2-pyridylmethyl)ethylenediamine-N,N'-diacetate(2-) (bped(2)(-)) have been prepared and isolated as either the hexafluorophosphate or perchlorate salts. The complexes have been characterized by (1)H and (13)C NMR, +LSIMS, IR, and elemental analysis. Complex formation constants have been measured in water at 25 degrees C (&mgr; = 0.16 M (NaCl)). log K (Ln(bped)](+)) (log K([Ln(bped)(OH)])): Ln = La, 10.81 (0.06); Ln = Nd, 11.99 (1.45); Ln = Gd, 12.37 (2.10); Ln = Ho, 12.31 (3.00); Ln = Yb, 13.42 (4.43). The stability constants for [M(bped)](+) increase from La(III) to Nd(III), plateau to Ho(III), and increase again to Yb(III), while the formation constants for [Ln(bped)(OH)] increase almost linearly with atomic number. The solution structures of the [Ln(bped)](+) complexes have been probed by multinuclear NMR ((1)H, (13)C, (17)O) studies, and these indicate only one isomer present in solution; this isomer has 2-fold symmetry and is rigid at 20 degrees C on the NMR time scale. (17)O NMR studies of the paramagnetic lanthanides indicate that the hydration number is 3, [Ln(bped)(H(2)O)(3)](+), and that an overall coordination number of 9 is maintained across the lanthanide series.
Multimodal In Vivo Imaging Exposes the Voyage of Nanoparticles in Tumor Microcirculation (2013)

Tumors present numerous biobarriers to the successful delivery of nanoparticles. Decreased blood flow and high interstitial pressure in tumors dictate the degree of resistance to extravasation of nanoparticles. To understand how a nanoparticle can overcome these biobarriers, we developed a multimodal in vivo imaging methodology, which enabled the noninvasive measurement of microvascular parameters and deposition of nanoparticles at the microscopic scale. To monitor the spatiotemporal progression of tumor vasculature and its vascular permeability to nanoparticles at the microcapillary level, we developed a quantitative in vivo imaging method using an iodinated liposomal contrast agent and a micro-CT. Following perfusion CT for quantitative assessment of blood flow, small animal fluorescence molecular tomography was used to image the in vivo fate of cocktails containing liposomes of different sizes labeled with different NIR fluorophores. The animal studies showed that the deposition of liposomes depended on local blood flow. Considering tumor regions of different blood flow, the deposition of liposomes followed a size-dependent pattern. In general, the larger liposomes effectively extravasated in fast flow regions, while smaller liposomes performed better in slow flow regions. We also evaluated whether the tumor retention of nanoparticles is dictated by targeting them to a receptor overexpressed by the cancer cells. Targeting of 100 nm liposomes showed no benefits at any flow rate. However, active targeting of 30 nm liposomes substantially increased their deposition in slow flow tumor regions (∼12-fold increase), which suggested that targeting prevented the washout of the smaller nanoparticles from the tumor interstitium back to blood circulation.
Cutting tools made from niobium carbide (2017)

The Federal Institute for Materials Research and Testing (BAM) and the Institute for Machine Tools and Factory Management (IWF) of the Technical University Berlin analyzed the suitability of various NbC types in comparison to tungsten carbide (WC) for use as a tool in cutting processes. The focus was placed on the optimization of the functional profile of NbC-based cutting materials with reproducible industrial production.