gebhart/patrepeval huggingface dataset:
Fractal analysis of retinal microvasculature and coronary heart disease mortality (2010)

D(f) is a novel means of quantifying microvascular branching that independently predicted 14-year CHD mortality. These findings suggest that suboptimal microvascular branching may play a role in development of clinical cardiovascular disease.
Female mouse fetal loss mediated by maternal autoantibody (2012)

Systemic lupus erythematosus (SLE), a disease of women during childbearing years, is characterized by the production of double-stranded DNA antibodies. A subset of these antibodies, present in 40% of patients, cross-reacts with the NR2A and NR2B subunits of the N-methyl-d-aspartate receptor (NMDAR). In this study, we show that, in mouse models, these antibodies cause a loss of female fetus viability by inducing apoptosis of NR2A-expressing neurons within the brainstem late in fetal development; gender specificity derives from a time-dependent increased expression of NR2A in female brainstem or increased vulnerability of female fetal neurons to signaling through NR2A-containing NMDARs. This paradigm is consistent with available data on the sex ratio of live births of women with SLE. It represents a novel mechanism by which maternal autoantibodies can severely affect fetal health in a gender-specific fashion and raises the question of how many maternal antibodies affect brain development or exhibit gender-specific fetal effects.
Tracking and Profiling Successful IT Graduates: An Exploratory Study (2002)

Data from the Course Experience Questionnaire (CEQ) and an internal UTS Student Satisfaction Survey repeatedly demonstrate that key factors in studentsâ judgements about the quality of their course are its relevance to professional practice, how up-to-date its content is and how well it continuously links university theory with workplace practice. This study addresses such issues by developing a tracking project that, in collaboration with existing UTS industry partners, taps the experience of âsuccessfulâ recent graduates and their views on the above issues.\nThe results demonstrate that successful graduates are not just technically competent. What distinguishes them is their emotional intelligence (both personal and social), a sharp, focused, contingent intellect and the possession of a specific set of generic skills. The results have important implications for current curriculum design and assessment in universities and for recruitment criteria in the areas investigated.
A DAVIC Video-on-Demand system based on the RTSP (2002)

The lack of a session to guarantee long-lived service and a function for control over the delivery of real-time streaming data in HTTP was a barrier in supporting a Video-on-Demand (VoD) service over the Internet. Recently, this barrier has been overcome with the introduction of the Real-Time Streaming Protocol (RTSP). This paper presents the design and implementation of an end-to-end DAVIC (Digital Audio-Visual Council)-based VoD system to support the RTSP over the Internet infrastructure. A RTSP client can select VCR-like requests, which are sent in RTSP message format to RTSP-DSM gateway. In RTSP-DSM gateway, the messages are transformed user control commands encapsulated in DSM-CC (Digital Storage Media-Command and Control) format and sent to the server. Upon receipt of transformed commands, the server invokes a CORBA-based DSM-CC service gateway and the media stream pump to actually perform the requested operations. The reply messages from the server are sent to the client in RTSP message format by RTSP-DSM gateway. Our VoD system has successfully completed feasibility via the Movie-on-Demand trials at our department. The main contribution of this work lies in a simple and effective system integration of a CORBA-based DAVIC VoD server and an RTSP-supported VoD client for MPEG transmission over the Internet via the LAN connection.
Learning Co-reference Relations for FOAF Instances (2010)

FOAF is widely used on the Web to describe people, groups and organizations and their properties. Since FOAF does not require unique IDs, it is often unclear when two FOAF instances are co-referent, i.e., denote the same entity in the world. We describe a prototype system that identifies sets of co-referent FOAF instances using logical constraints (e.g., IFPs), strong heuristics (e.g., FOAF agents described in the same file are not co-referent), and a Support Vector Machine (SVM) generated classifier.
Measurement of theB¯s0Effective Lifetime in theJ/ψf0(980)Final State (2012)

The effective lifetime of the B ¯(s)(0) meson in the decay mode B¯(s)(0)→J/ψf(0)(980) is measured using 1.0 fb(-1) of data collected in pp collisions at √s=7 TeV with the LHCb detector. The result is 1.700±0.040±0.026 ps, where the first uncertainty is statistical and the second systematic. As the final state is CP-odd, and CP violation in this mode is measured to be small, the lifetime measurement can be translated into a measurement of the decay width of the heavy B¯(s)(0) mass eigenstate, Γ(H)=0.588±0.014±0.009 ps(-1).
Assignment of the ǵene for F‐type phosphofructokinase to human chromosome 10 by somatic cell hybridization and specific immunoprecipitation (1980)

Summary A method of specific immunoprecipitation of minor isozymes was developed and applied to the detection of human F‐type phosphofructokinase in man‐rodent somatic cell hybrids. This method allowed us to assign the gene for this newly discovered isozyme of phosphofructokinase to chromosome 10.
OR02-6 Mass Spectrometry-Based Steroid Profiling Inprimary Bilateral Macronodular Adrenocortical Hyperplasia (2019)

Background: Biochemical characterization of primary bilateral macronodular adrenocortical hyperplasia (PBMAH) by distinct plasma steroid profiles and its putative correlation to disease has not been previously studied. Methods: LC-MS/MS-based steroid profiling of 16 plasma steroids was applied to 36 subjects (22 females, 14 males) with PBMAH, 19 subjects (16 females, 3 males) with other forms of adrenal CS (ACS), and an age and sex-matched control group. Germline ARMC5 sequencing was performed in all PBMAH cases. Results: The steroids showing the most dramatic differences between subject groups included 11-deoxycortisol, corticosterone, 11-deoxycorticosterone, 18-hydroxycortisol, progesterone and DHEA/DHEA-S. Steroids that showed isolated differences included cortisol and 18-oxocortisol with higher (P<0·05) concentrations in ACS than in controls, and aldosterone with higher concentrations in PBMAH when compared to controls. Larger differences in PBMAH than with ACS were most clear for corticosterone, but there were also trends in this direction for 18-hydroxycortisol and aldosterone. Logistic regression analysis indicated four steroids - DHEA, 11-deoxycortisol, 18-oxocortisol, and corticosterone - with the most power for distinguishing the groups. Discriminant analyses with step-wise variable selection indicated correct classification of 95·2% of all subjects of the four groups using a panel of nine steroids; correct classification of subjects with and without germline variants in ARMC5 was achieved in 91·7% of subjects with PBMAH. Conclusion: Subjects with PBMAH show distinctive plasma steroid profiles that may offer a supplementary single-test alternative for screening purposes.
ChemInform Abstract: Synthesis and Initial Structure—Activity Relationships of Modified Salicylihalamides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance (2014)

Abscisic acid (ABA) plays a crucial role in the plant's response to both biotic and abiotic stress. Sustainable production of food faces several key challenges, particularly the generation of new varieties with improved water use efficiency and drought tolerance. Different studies have shown the potential applications of Arabidopsis PYR/PYL/RCAR ABA receptors to enhance plant drought resistance. Consequently the functional characterization of orthologous genes in crops holds promise for agriculture. The full set of tomato (Solanum lycopersicum) PYR/PYL/RCAR ABA receptors have been identified here. From the 15 putative tomato ABA receptors, 14 of them could be grouped in three subfamilies that correlated well with corresponding Arabidopsis subfamilies. High levels of expression of PYR/PYL/RCAR genes was found in tomato root, and some genes showed predominant expression in leaf and fruit tissues. Functional characterization of tomato receptors was performed through interaction assays with Arabidopsis and tomato clade A protein phosphatase type 2Cs (PP2Cs) as well as phosphatase inhibition studies. Tomato receptors were able to inhibit the activity of clade A PP2Cs differentially in an ABA-dependent manner, and at least three receptors were sensitive to the ABA agonist quinabactin, which inhibited tomato seed germination. Indeed, the chemical activation of ABA signalling induced by quinabactin was able to activate stress-responsive genes. Both dimeric and monomeric tomato receptors were functional in Arabidopsis plant cells, but only overexpression of monomeric-type receptors conferred enhanced drought resistance. In summary, gene expression analyses, and chemical and transgenic approaches revealed distinct properties of tomato PYR/PYL/RCAR ABA receptors that might have biotechnological implications.
Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R (2003)

Mutations in the tau gene cause familial frontotemporal dementia and parkinsonism linked to chromosome 17. Here, we describe two Dutch families with familial frontotemporal dementia associated with the novel missense mutation L315R in exon 11 of tau. The age at onset of disease showed a large variation within each family, ranging from 25 to 64 years. Incomplete penetrance was established in an 82-year-old mutation carrier with no signs of dementia and appeared probable in two additional subjects. The brains of two affected subjects were studied and showed extensive tau pathology in neurons (Pick-like inclusions) and astroglial cells, particularly in the frontotemporal cortex and the hippocampal formation. Sarkosyl-insoluble tau extracted from the cerebral cortex showed the presence of straight and twisted tau filaments and a pattern of pathological tau bands similar to that of Pick's disease. Upon dephosphorylation, only five of the six brain tau isoforms were observed, with the shortest isoform being undetectable. All six tau isoforms were present in soluble brain tau. Recombinant tau proteins with the L315R mutation showed a reduced ability to promote microtubule assembly.
Dual unit visual intraocular prosthesis (2002)

The development of an implantable Artificial Retina Chipset (ARC) is presented, and the authors' current design, comprised of the Dual Unit Visual Intraocular Prosthesis, is described. This device will enable the over 10,000,000 people afflicted by retinal diseases such as retinal pigmentosa (RP) and age-related macular degeneration (AMD) to regain the sense of sight. This technology takes advantage of the fact that although these retinal diseases render the rods and cones inoperative, the ganglion cells lining the retina remain intact, and can respond to electrical stimulation. The ARC consists of a photosensing, processing, and stimulus-driving chip powered by solar cells which is connected to an electrode array. A photosensing, processing, and stimulus-driving chip has been fabricated and tested, and the chip performs in accordance with design specifications and biological parameters. The chip is capable of delivering the requisite currents for retinal stimulation in humans, as were determined by clinical studies conducted on the visually impaired with RP and AMD.
Herbicides as Weed Control Agents: State of the Art: II. Recent Achievements (2014)

In response to changing market dynamics, the discovery of new herbicides has declined significantly over the past few decades and has only seen a modest upsurge in recent years. Nevertheless, the few introductions have proven to be interesting and have brought useful innovation to the market. In addition, herbicide-tolerant or herbicide-resistant crop technologies have allowed the use of existing nonselective herbicides to be extended into crops. An increasing and now major challenge is being posed by the inexorable increase in biotypes of weeds that are resistant to herbicides. This problem is now at a level that threatens future agricultural productivity and needs to be better understood. If herbicides are to remain sustainable, then it is a must that we adopt diversity in crop rotation and herbicide use as well as increase the use of nonchemical measures to control weeds. Nevertheless, despite the difficulties posed by resistant weeds and increased regulatory hurdles, new screening tools promise to provide an upsurge of potential herbicide leads. Our industry urgently needs to supply agriculture with new, effective resistance-breaking herbicides along with strategies to sustain their utility.
An Exploration Strategy Improves the Diversity of de novo Ligands Using Deep Reinforcement Learning – A Case for the 3 Adenosine A2A Receptor (2018)

Over the last five years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be an effective method to generate novel chemical structures in the form of SMILES. However, ligands generated by current methods used to provide relatively little diversity and do not fully cover the whole chemical space occupied by known ligands. Here, we propose a new method (DrugEx) to discover de novo drug-like molecules. DrugEx is an RNN model (generator) trained through a special exploration strategy integrated into reinforcement learning. As a case study we applied our method to design ligands against the adenosine A2A receptor. From ChEMBL data, a machine learning model (predictor) was created to predict whether generated molecules are active or not. Based on this predictor as the reward function, the generator was trained by reinforcement learning without any further data. We then compared the performance of our method with two previously published methods, REINVENT and ORGANIC. We found that candidate molecules our model designed that were predicted to be active, had a larger chemical diversity, and better covered the chemical space of known ligands compared to the state-of-the-art.
Atomic layer deposition of quaternary chalcogenides (2023)

Methods and systems are provided for synthesis and deposition of chalcogenides (including Cu.sub.2ZnSnS.sub.4). Binary compounds, such as metal sulfides, can be deposited by alternating exposures of the substrate to a metal cation precursor and a chalcogen anion precursor with purge steps between.
Expression of the transcriptional activator tax protein of human T‐cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation (1993)

Abstract Human T‐cell leukemia virus type I (HTLV‐1) is the etiologic agent for adult T‐cell leukemia (ATL). Among the X region products of HTLV‐1, the p42 kDa protein Tax was identified, as responsible for cell immortalization and transformation. However, the observations that only a low percentage of individuals infected with HTLV‐1 eventually progress to leukemia and that leukemic transformation of HTLV‐1‐infected cells is associated with aberrant karyotype suggest that additional genetic events are required for HTLV‐1‐induced malignant transformation. Results of our study demonstrate that expression of the Tax protein of HTLV‐1 increased the radiosensitivity of a mouse fibroblast cell line. These data are consistent with a previous report indicating a negative regulatory control by Tax on DNA repair. Unrepaired DNA damage and karyotypic instability could represent a common factor in both the initiation and progression of HTLV‐1‐related diseases. © 1993 Wiley‐Liss, Inc.
Sub-optimal 3D volume convergence with time and fuel constraints (2003)

We consider the problem of detecting objects in a 3D region of space, using a mobile vehicle equipped with proximity sensors. A particular application is searching an area of the ocean for submarines using helicopters equipped with a dipping sonar. The vehicle can travel between any arbitrary points in the 3D space (a "move") and can decide to stop, collect, and process sensory data to determine the location of the objects (a "ping"). We assume that the only known a priori information are the probability distribution map of objects' location, and the 3D coverage region from each point in space. Each move and ping operation takes a certain amount of time and fuel. The objective is to find the sequence of moves and pings (a "bath") which maximize the expected value of detecting the objects given additional time and fuel constraints. Usually, the search space is very large and the search time is very small, such that it is not possible to exhaustively perform detect operations from each point. Using a discrete cubic cell decomposition of the search space, we pose the problem in both a discrete optimal control and a combinatorial optimization framework. We then investigate the numerical feasibility of several sub-optimal, polynomial type algorithms in solving the problem.
Lithium molybdenum nitride (LiMoN2): the first metallic layered nitride (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithium molybdenum nitride (LiMoN2): the first metallic layered nitrideS. H. Elder, Linda H. Doerrer, F. J. DiSalvo, J. B. Parise, D. Guyomard, and J. M. TarasconCite this: Chem. Mater. 1992, 4, 4, 928–937Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/cm00022a033https://doi.org/10.1021/cm00022a033research-articleACS PublicationsRequest reuse permissionsArticle Views1340Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of larger polypeptides structurally and functionally related to type I transforming growth factor. (1985)

Peptides corresponding to various regions of type I rat transforming growth factor (rTGF) have been chemically synthesized, conjugated to carrier protein, and used to immunized rabbits. An antiserum raised against one of these peptides, corresponding to the carboxyl-terminal 17 amino acids of rTGF, has been used to develop a competitive RIA for the immunizing peptide. In this assay, the antiserum reacts only with a restricted region of the immunizing peptide corresponding to the 11 carboxyl-terminal amino acids of the rTGF molecule. Intact rTGF competes as well as the immunizing peptide on a molar basis, indicating that the cognate sequence in rTGF is recognized by this antiserum. Mouse epidermal growth factor (mEGF) was ineffective as a competitor, even at a 10,000-fold greater concentration, showing that the RIA was capable of distinguishing TGF from functionally related proteins. Several immunoreactive species were detected by gel filtration of conditioned medium from cultured retrovirus-transformed rat cells; both a low molecular weight species that corresponds to rTGF, and a higher molecular weight specie(s) copurify with biologic activity in the EGF radioreceptor assay. Immunoblotting analysis of the higher molecular weight peak fractions revealed three polypeptides (MrS, 24,000, 40,000, and 42,000) that reacted specifically with the antiserum. These findings suggest the existence of a family of larger polypeptides containing both structural and functional determinants of rTGF.
Complex B1+ mapping with Carr‐Purcell spin echoes and its application to electrical properties tomography (2021)

The CP sequence can be used to simultaneously provide both B<sub>1</sub><sup>+</sup> magnitude and phase estimations, and therefore allows for full reconstruction of the electrical properties.
ChemInform Abstract: CATALYTIC REDUCTION OF NITRIC OXIDE WITH AMMONIA OVER COPPER(II) NAY (1979)

Abstract Der Mechanismus der katalytischen Reduktion von NO mit NH 3 (Gleichung A) an der Cu(II)‐Forrn eines Y‐Zeolithen wird mit Hilfe kinetischer und Tracerisotopen‐Methoden sowie Regenerierungsexperimenten der Cu(II)‐Ionen aus Cu(I) im reduzierten Katalysator untersucht.
Architecture for hardware thinning and crest restoration in graylevel images (2004)

In this article we present the segmentation chain based on contour detection including contour detection followed by thinning and crest restoration of contours. The thinning and crest restoration algorithms are based on topological notions. These algorithms allow us to enhance the segmentation process. This article presents the study to implement edge detection, thinning and crest restoration algorithms on a XCV 300 Virtex FPGA based architecture. The proposed architecture for the thinning and crest restoration operators is based on an optimized architecture for the topological classifier of the characteristics of the point.
Selective Androgen Receptor Modulator (SARM) Action: Androgen Therapy Revisited (2008)

Despite continuing advances in the clinical development of selective androgen receptor modulators (SARMs) for male hypogonadism, osteoporosis, muscle wasting and myriad diseases of the prostate, mechanism remains controversial.To date, mechanistic work in the selective hormone receptor modulator (SRM) field has been dominated by selective estrogen receptor modulators (SERMs) where a full understanding of SERM action contributed to the development of second generation molecules with better selectivity and reduced side effects.It follows that a better understanding of SARM action could lead to improvements in rationale SARM design and even molecules tailor made for specific patient populations or disease states.The studies described herein were -6.5 kb -6.0 kb -5.5 kb -5.5 kb -5.0 kb -4.5 kb -4.5 kb -4.0 kb -3.5 kb -3.5 kb -3.0 kb -2.5 kb -2.5 kb -2.0 kb -1.5 kb -1.5 kb -1.0 kb -0.5 kb TSS + 0.5 kb -0.5 kb + 0.5 kb 1.0 kb -6.5 kb -6.0 kb -5.5 kb -5.5 kb -5.0 kb -4.5 kb -4.5 kb -4.0 kb -3.5 kb -3.5 kb -3.0 kb -2.5 kb -2.5 kb -2.0 kb -1.5 kb -1.5 kb -1.0 kb -0.5 kb TSS + 0.5 kb -0.5 kb + 0.5 kb 1.0 kb ALT-2 Promoter Scan V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M SARM3 -FC vs. Vehicle (ChIP/Input) AR Pol II * p<.05 Versus corresponding vehicle (Fisher's LSD)V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M V e h 1 0 0 n M