gebhart/patrepeval huggingface dataset:
KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction (2009)

Kisspeptins, the products of the KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54), have recently emerged as pivotal signals in the hypothalamic network triggering the preovulatory surge of gonadotropins and, hence, ovulation. Additional actions of kisspeptins at other levels of the hypothalamic-pituitary-ovarian axis have been suggested but remain to date scarcely studied. We report herein the pattern of expression of KiSS-1 and GPR54 in the human and nonhuman primate ovary and evaluate changes in ovarian KiSS-1 expression in a rat model of ovulatory dysfunction. KiSS-1 and GPR54 mRNAs were detected in human ovarian tissue and cultured granulosa-lutein cells. In good agreement, kisspeptin immunoreactivity was observed in cyclic human and marmoset ovaries, with prominent signals in the theca layer of growing follicles, corpora lutea, interstitial gland, and ovarian surface epithelium. GPR54 immunoreactivity was also found in human theca and luteal cells. Administration of indomethacin to cyclic female rats disturbed ovulation and resulted in a dramatic drop in ovarian KiSS-1, but not GPR54, cyclooxygenase-2 (COX-2), or progesterone receptor, mRNA levels at the time of ovulation; an effect mimicked by the selective COX-2 inhibitor NS398 and rescued by coadministration of PGE(2). Likewise, the stimulatory effect of human choriogonadotropin on ovarian KiSS-1 expression was partially blunted by indomethacin. In contrast, KiSS-1 mRNA levels remained unaltered in another model of ovulatory failure, i.e., the RU486-treated rat. In summary, we document for the first time the expression of KiSS-1/kisspeptin and GPR54 in the human and nonhuman primate ovary. In addition, we provide evidence for the ability of inhibitors of COX-2, known to disturb follicular rupture and ovulation, to selectively alter the expression of KiSS-1 gene in rat ovary. Altogether, our results are suggestive of a conserved role of local KiSS-1 in the direct control of ovarian functions in mammals.
ChemInform Abstract: Photoelectrochemical Properties of TiO2 Anatase Films Synthesized via the Sol‐Gel Process. (1990)

Abstract Cr3+‐Al 3+ doped TiO 2 (anatase) photoanodes, obtained from a solution of Ti(BuO) 4 , Al(sBuO)4, and Cr(acac)3 (98% Ti, 1% Al, 1% Cr) by spin coating on a Ti foil and subsequent treating at under a H2‐argon mixture, exhibit a flat‐band potential of ∼‐100 mV vs.
The Ionospheric Model Improvement for the Stanford WAAS Network (1995)

The Wide Area Augmentation System (WAAS) was
invented mainly to solve the spatial decorrelation
problem of GPS differential corrections. One of the
important messages generated by the WAAS contains
the ionosphere model parameters for single frequency
users. However, ionospheric delay measurements of
the GPS signal can be corrupted by the inter-frequency
biases from both the transmitters (GPS satellites)
and the receivers at the Wide Area reference stations
(WRS). Therefore the ionosphere model generated by
the WAAS master station will be both skewed and biased.
This paper describes the characteristics of the biases
and presents an inter-frequency bias estimation algorithm 
for creating an improved ionospheric delay
model. This algorithm can be either implemented
at each of the WRS’s individually or at the Wide
Area Master Station (WMS). The data, taken at mid-
afternoon during the winter season, show better than
0.5-meter consistency when compared using any one of
several checking methods. The ionosphere model 
generated by the Stanford WAAS network, yielded smaller
user ionosphere-related errors after applying the 
estimated biases to adjust the ionospheric delay 
measurement. The ionospheric delay models used for this
study are a modified Grid algorithm and a Spherical
Harmonics expansion.
Perfluoro Macrocyclic Ether as an Ambifunctional Additive for High‐Performance SiO and Nickel 88%‐Based High‐Energy Li‐ion Battery (2023)

Abstract State‐of‐the‐art lithium (Li)‐ion batteries employ silicon anode active material at a limited fraction while strongly relying on fluoroethylene carbonate (FEC) electrolyte additive exceeding 10 wt.% to enable stable cycling. The swelling issue of silicon in the aspect of solid electrolyte interphase (SEI) instability and a risk of safety hazards and high manufacturing cost due to FEC has motivated the authors to design a well‐working fluorinated additive substitute. High‐capacity cells employing nickel‐rich oxide cathode are pursued by operating at &gt; 4.2 V versus Li/Li + , for which anodic stability of electrolyte is required. Herein, a highly effective new ambifunctional additive of icosafluoro‐15‐crown 5‐ether is proposed at a little fraction of 0.4 wt.% for the stabilized interfaces and reduced swelling of high capacity (3.5 mAh cm −2 ) 5 wt.% SiO‐graphite anode and LiNi 0.88 Co 0.08 Mn 0.04 O 2 cathode. Utilizing together with a lowered fraction of FEC, reversible long 300 cycles at 4.35 V and 1 C (225 mA g −1 ) are achieved. Material characterization results reveal that such stabilization is derived from the surface passivation of both anode and cathode with perfluoro ether, LiF, and Li x PF y species. The present study gives insight into electrolyte formulation design with lower cost and both‐side stabilization strategies for silicon and nickel‐rich active materials and their interfaces.
Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges (2021)

Our findings provide proof-of-concept for the lyophilization of drug-containing CCPM and our methodology is readily translatable to large-scale manufacturing for future commercialization.
High Capacity and Excellent Cyclability of Nano-Silicon/CB/CMC Composite Anode from Tailored Electrode Preparation (2009)

Abstract not Available.
Intelligent hybrid cooperative spectrum sensing: A multi-stage decision fusion approach (2017)

Cooperative spectrum sensing is a powerful sensing approach which is based on sharing information about channel activities among secondary users (SUs). Cooperative spectrum sensing aims to overcome hidden node problem, shadowing and fading problems, it also enhances sensing accuracy. However, sensing accuracy may degrade due to various reasons: if environmental properties are poor or intra-node characteristics are continuously altering. Thus, this paper proposes a novel approach of a multi-stage hybrid cooperative spectrum sensing model. The first stage, integrates a fuzzy logic system for local fusion center, whereby SU-mobility and its environmental properties, and its neighbors' environmental properties are included in local sensing decision process. Second stage proposes a neural network, based on backpropagation learning algorithm, for global fusion center. All SUs transmit their sensing information, local decision, and their intra-node characteristics to be augmented for an optimized global sensing decision. Neural network is trained based on a real-world measured power dataset. Extensive simulations on the proposed multi-stage model were performed. The results showed high robustness against instantaneous changes in SU-mobility levels and good detection performance at very low signal-to-noise ratio (SNR) levels. The proposed prediction model outperformed the state-of-the-art work with high detection accuracy at very poor environmental conditions and at different speeds levels.
Electron-Pair Donors in Carbocationic Polymerization. III. Carbocation Stabilization by External Electron-Pair Donors in Isobutylene Polymerization (1989)

Abstract The polymerization of isobutylene (IB) initiated by a variety of tertiary chloride/TiCl4 or BC13 systems can be very beneficially influenced by deliberately added electron-pair donors (ED's). ED's whose Gutmann's donor number is larger than ∼26, e.g., dimethylsulfoxide (DMSO) and dimethylacetamide (DMA), are most suitable to mediate numerous most desirable effects. Thus, in the presence of DMSO or DMA: (1) quasi-living polymerizations initiated by cumyl chloride (CumCl)/TiCl4 or 2-chloro-2,4,4-trirnethylpentane (TMPCl)/TiCl4 give rise to very narrow molecular weight distribution (MWD) polyisobutylene (PIB) ( M w / M n = 1.1–1.2); (2) the CumCl/BCl3/IB inifer system becomes living and yields PIB with very narrow MWD; (3) the polymerization-inactive TMPCl/BCl3 system becomes active and induces living IB polymerization to narrow-MWD product; (4) indanyl end-group formation, which may occur in the CumCl/BCl3 or p-dicumyl chloride/BCl3, inifer systems, is eliminated. The effect of reaction conditions, e.g., polarity and [TiCl4]/([CumCl] + [DMSO]) ratio, on these polymerizations has been investigated. All the observations and effects can be explained by a reduction of cationicity of the polymerization-active species by ED's.
Motivation and future intentions of dental students in Karachi, Pakistan (2019)

Background: However, it is not enough to simply produce an influx of dentists. Therefore, it is of utmost importance to understand the motivates of young individuals into pursuing career in dentistry to map and explore avenues for dentistry career.Objective: The objective was to assess the motivation of dental students in pursuing dentistry and to investigate the career choices of dental students immediately after graduation.Study type and settings: The Cross sectional study was conducted at different government and private dental colleges in Karachi. Subjects and Methods: All the participants were asked to fill a questionnaire. The questionnaire comprised of three parts; first part consisted of bio-data, the second and the third part consisted of questions related to study motives and future career choices of fresh dental graduates.Results: One hundred and sixty five (165) dental house officers were approached, out of which, eighty five (n=85, 51.55%) participants expressed a preference to pursue post-graduate studies after completion of house job, twenty nine (n=29, 17.6%) chose private practice and nineteen (n=19, 11.5%) wanted to pursue a foreign licensure exam.Conclusion: A significant effort needs to be made to encourage the graduates to pursue this field as a full time opportunity.
ChemInform Abstract: Evaluation of Phosphorus‐Containing Inhibitors of γ‐Glutamyl Hydrolase. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Collaborative Sensemaking Tools for Task Forces (2009)

Our work addresses the needs of multiple information workers collaborating on joint projects, which typically require finding, analyzing, and synthesizing information from heterogeneous sources. We report on iterative design, implementation, and assessment of collaborative tools for sensemaking tasks. Our goal is flexible, lightweight tools that both facilitate the activities done individually and lower the costs of effective collaboration. We suggest several approaches to enhance such collaborative sensemaking tools. These approaches include explicit representation of multiple team activities, integrated support for synchronous communication, and views of collected information that are tuned to both the reading and organizing phases of sensemaking. We present an integrated pair of tools, ContextBar and ContextBook, which illustrate these approaches, and describe the results from a formative evaluation of these tools.
Identification of Novel Candidate Tumor Suppressor Genes Using C. elegans as a Model. (1996)

Abstract : Molecular genetic analysis of the model organism Caenorhabditis elegans was used to identify and study mechanisms of action of negative regulators of tyrosine kinase/ras mediated signal transduction that are candidate tumor suppressors. A homolog of the proto oncogene cbl, SLI-1, inhibits Ras activation by the epidermal growth factor receptor homolog LET-23. The domain of human c-cbl most highly conserved functions in C. elegans when substituted for the homologous region of SLI-1. Proteins that interact with this region of SLI-1 have been identified by a two-hybrid screen in yeast. ROK-1, a novel tyrosine kinase, has been characterize. Both SLI-1 and ROK-1 have proline-rich domains that are necessary for their function. New screens for additional negative regulators have identified at least three genes that are now being analyzed. Human homologs of ROK-1 are now being sought.
A Comparison of the Neutron Response of CR-39 Made by Different Manufacturers (1992)

Journal Article A Comparison of the Neutron Response of CR-39 Made by Different Manufacturers Get access N.E. Ipe, N.E. Ipe Search for other works by this author on: Oxford Academic PubMed Google Scholar J.C. Liu, J.C. Liu Search for other works by this author on: Oxford Academic PubMed Google Scholar B.R. Buddemeier, B.R. Buddemeier Search for other works by this author on: Oxford Academic PubMed Google Scholar C.J. Miles, C.J. Miles Search for other works by this author on: Oxford Academic PubMed Google Scholar R.C. Yoder R.C. Yoder Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 44, Issue 1-4, 1 November 1992, Pages 317–321, https://doi.org/10.1093/rpd/44.1-4.317 Published: 01 November 1992
Human Periodontal Ligament Stem Cell and Umbilical Vein Endothelial Cell Co-Culture to Prevascularize Scaffolds for Angiogenic and Osteogenic Tissue Engineering (2021)

(1) Background: Vascularization remains a critical challenge in bone tissue engineering. The objective of this study was to prevascularize calcium phosphate cement (CPC) scaffold by co-culturing human periodontal ligament stem cells (hPDLSCs) and human umbilical vein endothelial cells (hUVECs) for the first time; (2) Methods: hPDLSCs and/or hUVECs were seeded on CPC scaffolds. Three groups were tested: (i) hUVEC group (hUVECs on CPC); (ii) hPDLSC group (hPDLSCs on CPC); (iii) co-culture group (hPDLSCs + hUVECs on CPC). Osteogenic differentiation, bone mineral synthesis, and microcapillary-like structures were evaluated; (3) Results: Angiogenic gene expressions of co-culture group were 6-9 fold those of monoculture. vWF expression of co-culture group was 3 times lower than hUVEC-monoculture group. Osteogenic expressions of co-culture group were 2-3 folds those of the hPDLSC-monoculture group. ALP activity and bone mineral synthesis of co-culture were much higher than hPDLSC-monoculture group. Co-culture group formed capillary-like structures at 14-21 days. Vessel length and junction numbers increased with time; (4) Conclusions: The hUVECs + hPDLSCs co-culture on CPC scaffold achieved excellent osteogenic and angiogenic capability in vitro for the first time, generating prevascularized networks. The hPDLSCs + hUVECs co-culture had much better osteogenesis and angiogenesis than monoculture. CPC scaffolds prevacularized via hPDLSCs + hUVECs are promising for dental, craniofacial, and orthopedic applications.
Organic Deposits in Oil and Gas Production (2010)

Organic Deposits in Oil and Gas Production provides an overview of the science and technology of organic solids formation, deposition, removal, and prevention, with emphasis on the basic chemical and mechanical principles of deposition control. Chapters describe the flow systems in which arterial deposits occur, place the technical aspects of deposition management in the perspective of the upstream oil and gas business, and address multiple aspects of organic deposits, including the chemical and physical driving forces for deposit formation, the methods for managing deposits, and the simulation tools that may be used to forecast the magnitude of potential problems.
Imaging the stability of chronic electrical microstimulation using electrodes coated with PEDOT/CNT and iridium oxide (2022)

Chronic microstimulation is faced with challenges that require an additional understanding of stability and safety. We implanted silicon arrays coated with poly(3,4-ethylenedioxythiophene) (PEDOT)/Carbon Nanotubes (CNT), or PCand IrOx into the cortex of GCaMP6s mice and electrically stimulated them for up to 12 weeks. We quantified neuronal responses to stimulation using two-photon imaging and mesoscale fluorescence microscopy and characterized electrode performance over time. We observed dynamic changes in stimulation stability over time and a significant advantage in energy efficiency using PC coated electrodes over IrOx coated electrodes. In a subset of mice, we observed abnormal ictal cortical responses or cortical spreading depression using stimulation parameters commonly used in intracortical stimulation applications, suggesting the need to investigate the potential neuronal damage and redefine the stimulation safety limit. This study not only revealed the dynamic changes in stimulation efficiency after implantation but also reiterates the potential for PC as a high-efficiency material in chronic neuromodulation.
Automatic Measurement of Lead Time of Repetitive Assembly Work in a Factory Using a Wearable Sensor (2017)

In this paper, we attempt to estimate lead time (duration) of each period of an operation process by a factory worker using a wrist-worn accelerometer. In a factory line production system, a worker repetitively performs predefined operation processes, and the lead time greatly affects productivity of the line production system. Our proposed method automatically finds a frequent sensor data segment as a “motif” that occurs once in each operation period using only prior knowledge about predefined standard lead time of the operation process, and uses the occurrence intervals of the motif to estimate the lead time.
Transformation of Extra-Large Pore Germanosilicate CIT-13 Molecular Sieve into Extra-Large Pore CIT-5 Molecular Sieve (2019)

The 14- and 10-membered ring germanosilicate Ge-CIT-13 (*CTH) is transformed into the 14-membered ring germanosilicate Ge-CIT-5 (CFI). The transformation can occur at room temperature but requires the presence of adsorbed water. The *CTH-to-CFI transformation involves rearrangement of germanium-rich double-4-ring units in *CTH to form double-zigzag chains in CFI. The rate of transformation is dependent on the germanium content of the starting Ge-CIT-13 and the humidity of the transforming atmosphere. Other germanosilicates—UTL, IWW, and ITH—do not show this type of transformation because of arrangements of Ge-sites within their d4r units and/or to spatial restrictions regarding the d4r unit arrangement within their interlayer regions. Ge-CIT-5 can be further transformed into 10-membered-ring CIT-15 using ammonium hydroxide solution as the delaminating agent. Postsynthetic alumination of Ge-CIT-5 yielded high-silica CFI-type aluminogermanosilicates having molar Si/Al ratios in the range of 14–230, primarily depending on the acidity of the solution phase.
Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an In Silico Trial (2021)

The quantification of carb-counting error impact performed in this work may be useful understanding causes of glycemic variability and the impact of possible therapy adjustments or behavior changes in different glucose metrics.
Computing with Services (2004)

This chapter contains sections titled: Visions for the Web Precursors Open Environments Services Introduced Using Services The Evolving Web Standards Bodies Overview of this Book Notes Exercises
Revealing complete complex KIR haplotypes phased by long-read sequencing technology (2017)

The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to 16 genes for natural killer (NK) cell receptors that recognize human leukocyte antigen (HLA)/peptide complexes and other ligands. The KIR proteins fulfill functional roles in infections, pregnancy, autoimmune diseases and transplantation. However, their characterization remains a constant challenge. Not only are the genes highly homologous due to their recent evolution by tandem duplications, but the region is structurally dynamic due to frequent transposon-mediated recombination. A sequencing approach that precisely captures the complexity of KIR haplotypes for functional annotation is desirable. We present a unique approach to haplotype the KIR loci using single-molecule, real-time (SMRT) sequencing. Using this method, we have-for the first time-comprehensively sequenced and phased sixteen KIR haplotypes from eight individuals without imputation. The information revealed four novel haplotype structures, a novel gene-fusion allele, novel and confirmed insertion/deletion events, a homozygous individual, and overall diversity for the structural haplotypes and their alleles. These KIR haplotypes augment our existing knowledge by providing high-quality references, evolutionary informers, and source material for imputation. The haplotype sequences and gene annotations provide alternative loci for the KIR region in the human genome reference GrCh38.p8.
ChemInform Abstract: New Base‐Altered Adenosine Analogues: Synthesis and Affinity at Adenosine A1 and A2A Receptors. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In vivo three-dimensional velocity vector imaging and volumetric flow rate measurements (2013)

The three-dimensional (3-D) Transverse Oscillation (TO) method is used to obtain 3-D velocity vector estimates in two orthogonal planes. The method is suitable for a real-time implementation. Data are acquired using a Vermon 3.0 MHz 32×32 element 2-D phased array and the experimental ultrasound scanner SARUS. Measurements are conducted on a carotid artery flow phantom from Danish Phantom Design, and 20 frames are acquired with a constant flow rate of 16.7±0.17 mL/s provided by a Shelley Medical Imaging Technologies CompuFlow 1000 system. The peak velocity magnitude in the vessel is found to be 52.3±8.1 m/s compared to an expected peak velocity of 53.6±0.54 cm/s. Based on the out-of-plane velocity component in the cross-sectional plane, the estimated volumetric flow rates are 17.1±1.4 mL/s. The coefficient of variation is 8.3%, and the bias is 2.2%. An in vivo measurement of 3-D M-mode velocities is conducted over five heart beats. The peak systolic and end-diastolic velocities are 69±5.4 cm/s and 7.9±5.5 cm/s at the center of the vessel. For comparison, a commercial BK Medical ultrasound scanner using the spectral estimator yields 71.2 cm/s and 7.70 cm/s, respectively. The results demonstrate that the 3-D TO method can estimate 3-D velocities in two crossed planes, volumetric flow rates, and 3-D velocities in vivo.
Optimizing the domain wall fermion Dirac operator using the R-Stream source-to-source compiler (2016)

The application of the Dirac operator on a spinor field, the Dslash operation, is the most computation-intensive part of the lattice QCD simulations. It is often the key kernel to optimize to achieve maximum performance on various platforms. Here we report on a project to optimize the domain wall fermion Dirac operator in Columbia Physics System (CPS) using the R-Stream source-to-source compiler. Our initial target platform is the Intel PC clusters. We discuss the optimization strategies involved before and after the automatic code generation with R-Stream and present some preliminary benchmark results.