gebhart/patrepeval huggingface dataset:
Modified PVA–Fe3O4 Nanoparticles as Protein Carriers into Sperm Cells (2008)

Magnetite nanoparticles conjugated to protein are developed in order to potentially serve as protein carriers into bovine sperm cells. The conjugate comprises iron oxide nanoparticles that are covalently bound to an anti-protein kinase C (PKC)alpha antibody. This conjugate can serve for cellular PKC localization and the inhibition of its function. The surface of the nanoparticle is first modified with (3-aminopropyl) thrimethoxysilane to form a self-assembled monolayer, and subsequently conjugated with the antibody through amidation between the carboxylic acid end groups on the antibody and the amine groups on the surface of the nanoparticles. The anti-PKCalpha localization is proven by fluorescent microscopy and iron staining. The activity of the anti-PKCalpha conjugated with the nanoparticle is tested by recognizing PKCalpha using the Western blot method.
Carbon Hybrids Graphite-Hard Carbon and Graphite-Coke as Negative Electrode Materials for Lithium Secondary Batteries Charge/Discharge Characteristics (2002)

Electrochemical characteristics of the hybrid carbon (HC) graphite-hard carbon and graphite-coke have been investigated for the application of these materials as negative electrodes in lithium secondary batteries with a long cycle life. The graphite-hard carbon HC showed a higher reversible lithium capacity and better cycle performance than did the graphite-coke HC. X-ray photoelectron spectroscopy and nuclear magnetic resonance spectroscopy were used to analyze the deterioration mechanisms of the graphite-HC and graphite-coke HC. The decomposition products after the charge/discharge cycles were considered to be LiF and a carbonate compound, and the increase in inactive lithium in the decomposition products for the graphite-hard carbon HC was smaller than that for the graphite-coke HC. Therefore, it was thought that the graphite-hard carbon HC negative electrode suppressed the decomposition of the electrolyte and showed better cycle performance than did the graphite-coke HC negative electrode. Consequently, graphite-hard carbon HC is a promising negative electrode material for long-life lithium secondary batteries for dispersed-type energy storage systems. © 2002 The Electrochemical Society. All rights reserved.
Complexations of 2-thiouracil and 2,4-dithiouracil with Cd(SeCN)2and Hg(SeCN)2: NMR and anti-bacterial activity studies (2011)

Cadmium and mercury selenocyanate complexes of 2-thiouracil (TU) and 2,4-dithiouracil (DTU) ligands have been synthesized to form complexes of the type [M(SeCN) 2 (TU)] and [M(SeCN) 2 (DTU)] (where M is Cd 2+ or Hg 2+ ) and studied by various spectroscopic techniques such as IR, 1 H and 13 C NMR in solution and in the solid state for 13 C, 15 N, and 113 Cd nuclei. Based on IR, and solution and solid-state 13 C NMR data, stronger cadmium bonding to the thiouracil was observed compared to that of mercury. Anti-bacterial activities of these complexes have been investigated with standard type culture of Escherichia coli (MTCC 443), Klebsiella pneumoniae (MTCC 109), Pseudomonas aeruginosa (MTCC 1688), Salmonella typhi (MTCC 733) and Staphylococcus aureus (MTCC 737) and show that ligands exhibit more anti-bacterial activities than that of the corresponding Cd(II) and Hg(II) complexes.
Notice of Removal: A model-based approach for estimating local speed of sound in tissue using pulse echo ultrasound (2017)

Removed.
The effects of manufacturing progress function on machine requirements and aggregate planning problems (1988)

Abstract The existing models for machine requirements planning are based on the assumption of a constant production rate per machine throughout the planning horizon. This assumption is not valid in many production environments where the manufacturing productivity increases because of factors like: product and process redesign, more efficient maintenance and setup procedures, direct-labour learning, reduction of scrap losses, etc. The objective of this paper is to present the effects of improving manufacturing productivity on machine requirements planning, In addition, an integrated model which combines the aggregate production planning and machine requirements planning problems is discussed under the effects of manufacturing progress function.
Mechanical Model of Globular Transition in Polymers (2014)

Abstract In complex, multicomponent systems, polymers often undergo phase transitions between distinct conformations. This paper reports a millimeter‐scale granular model of coil‐to‐globule transitions: one “polymer” chain—a cylinders‐on‐a‐string “pearl necklace”—and many spheres, all shaken on a horizontal surface. It is possible to describe the behavior of this granular system by using formalisms generally used in statistical physics of polymers. Two sets of experiments allowed the observation of first‐ and second‐order coil‐to‐globule transitions. The model shows that the competition between long‐ and short‐range interactions leads to a first‐order transition. Well‐designed granular system represents another kind of approach to the study of polymer phase transitions and might inspire future designs of polymer‐like mesoscale systems.
Rapid Thermal Reduction of Inkjet Printed Cu Interconnects on Glass Substrate (2011)

We report on rapid thermal reduction of inkjet-printed Cu interconnects in nitrogen and hydrogen mixture ambient to change the insulating Cu2O to conductive Cu for solution-based all printable thin film transistors fabricated on a glass substrate. By ink-jetting and rapid thermal annealing of nano Cu ink with an average size of ∼6 nm, we were able to obtain directly patterned Cu interconnects with resistivity of 2.2 × 10−6 Ω cm and line width of ∼50 μm. Synchrotron x-ray scattering and x-ray photoelectron analysis showed that as-printed Cu interconnect, which existed in the Cu2O phase was completely transformed to metallic Cu interconnects after rapid thermal annealing due to effective reduction by H2 gas and sintering of inkjet-printed Cu that have a lower melting point than bulk Cu.
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids (2020)

ABSTRACT Neuropsychiatric and neurodevelopmental disorders have been particularly challenging to study using animal models, and recently, human-derived cerebral organoids demonstrate great promise for discovering molecular processes that are important in these disorders. However, several challenges remain in achieving robust phenotyping to discover cell type specific genes. We perform RNA sequencing on 71 samples comprising of 1,420 cerebral organoids from 25 donors, and describe a framework (Orgo-Seq) to identify cell type specific driver genes, for 16p11.2 deletions and 15q11-13 duplications. We identify neuroepithelial cells as critical cell types for 16p11.2 deletions, and discover novel and previously reported cell type specific driver genes. Finally, we validated our results that mutations in KCTD13 in the 16p11.2 locus lead to imbalances in the proportion of neuroepithelial cells, using CRISPR/Cas9-edited mosaic organoids. Our work presents a quantitative discovery and validation framework for identifying cell type specific driver genes associated with complex diseases using cerebral organoids.
Comparative Constitutional Law: Entering the Quagmire [Article] (1989)

This material published in Arizona Journal of International and Comparative Law is made available by the James E. Rogers College of Law, the Daniel F. Cracchiolo Law Library, and the University of Arizona Libraries. If you have questions, please contact the AJICL Editorial Board at http://arizonajournal.org/contact-us/.
Photoreactive Nanoparticles as Nanometric Building Blocks for the Generation of Self‐Healing Hydrogel Thin Films (2011)

The use of reversible photo-cross-linkable nanoparticles as nano building blocks for the formulation of nanostructured self-healing thin hydrogel films is shown for the first time. This strategy for the fabrication of autonomous self-healing coatings consisted of various microgels bearing surface cinnamate moieties. The nanoparticles were formed by miniemulsion copolymerization, which was followed by surface functionalization with the cinnamate groups. These nanoparticles were then used to form films by drop-casting, followed by interparticle photo-cross-linking polymerization through the light-induced forward dimerization reaction of the previously incorporated cinnamate groups. The reversibility of this macroscopic network formation was also demonstrated by photoinducing the backward dimerization reaction and carrying out several cycles of photoinduced cross-linking and de-cross-linking. The self-healing ability through swelling of these films following surface damage was also demonstrated. Finally, the ability of these self-healing macroscopic films to incorporate additives of different chemical nature before photo-cross-linking was evaluated.
Three-Dimensionally-Patterned Submicrometer-Scale Hydrogel/Air Networks That Offer a New Platform for Biomedical Applications (2008)

Phase mask interference lithography was employed to fabricate three-dimensional (3D) hydrogel structures with high surface area on neural prosthetic devices. A random terpolymer of poly(hydroxyethyl methacrylate- ran-methyl methacrylate- ran-methacrylic acid) was synthesized and used as a negative-tone photoresist to generate bicontinuous 3D hydrogel structures at the submicrometer scale. We demonstrated that the fully open 3D hydrogel/air networks can be used as a pH-responsive polymeric drug-release system for the delivery of neurotrophins to enhance the performance of neural prosthetic devices. Additionally an open hydrogel structure will provide direct access of neuronal growth to the device for improved electrical coupling.
Effects of Gaze on Multiparty Mediated Communication (2000)

We evaluated effects of gaze direction and other non-verbal visual cues on multiparty mediated communication. Groups of three participants (two actors, one subject) solved language puzzles in three audiovisual communication conditions. Each condition presented a different selection of images of the actors to subjects: (1) frontal motion video; (2) motion video with gaze directional cues; (3) still images with gaze directional cues. Results show that subjects used twice as many deictic references to persons when head orientation cues were present. We also found a linear relationship between the amount of actor gaze perceived by subjects and the number of speaking turns taken by subjects. Lack of gaze can decrease turn-taking efficiency of multiparty mediated systems by 25%. This is because gaze conveys whether one is being addressed or expected to speak, and is used to regulate social intimacy. Support for gaze directional cues in multiparty mediated systems is therefore recommended.
Advanced video technologies to support collaborative learning in school education and beyond (2005)

The aim of the paper is to characterize two new advanced video technology software systems developed for uses in collaborative learning (DIVER and HyperVideo2), and how they extend the paradigms of video use in classrooms today. The rationale for and characteristics of these tools are described, and early experiences with their use are characterized.
Organ-Specific Oxidative Events under Restrictive Versus Full Reperfusion Following Hemorrhagic Traumatic Shock in Rats (2018)

Restrictive reperfusion after HTS is associated with increased ROS formation in erythrocytes and liver compared to sham controls. Moreover, the restrictive reperfusion is associated with a more pronounced injury to the liver and kidney, which is likely mediated by other than lipid peroxidation process and/or oxidative stress reactions.
Mid-infrared Beam Propagation and Modulation in Extraordinary Transmission Gratings (2008)

We have characterized laser beam propagation, with up to 10W power, through an extraordinary transmission grating fabricated on GaAs. The grating was designed to have a 10 µm fundamental resonance at the metal/dielectric interface.
Scrambled Coded Multiple Access, Variations and Improvements (2018)

A family of new non-orthogonal multiple access techniques named Scrambled Coded Multiple Access (SCMA) is described. It allows different users of a communications system to efficiently share the same bandwidth by using specific scramblers to separate user bursts. SCMA technology is designed for satellite communications with extremely small antenna terminals for potential applications such as asset tracking, sensor networking, and smart grid; and also for latency reduction. The latest variation, Asynchronous Scrambled Coded Multiple Access (A-SCMA) on the other hand, not only removes the need for timeslot synchronization and precise power control, but also offers an unprecedented system throughput of more than 4 bits/symbol at a modest per user signal to noise ratio (SNR).
Comparison of Photo-oxidation Reactions in Batch and a New Photosensitizer-Immobilized Microfluidic Device (2012)

A glass microfluidic device has been functionalized with photoactive porphyrins for performing reactions which are mediated by singlet molecular oxygen. The resulting device was used to investigate the photochemical oxidation of cholesterol, α-terpinene, and citronellol under flow conditions, and the results were compared with similar batch reactions.
New and Efficient Synthesis of Racemic Cyclopent‐3‐en‐1‐yl Nucleoside Analogues and Their Derivatives. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Activation of protease-activated receptors by gingipains fromPorphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity (2001)

The bacterium Porphyromonas gingivalis is a major etiologic agent in the pathogenesis of adult periodontitis in humans. Cysteine proteinases produced by this pathogen, termed gingipains, are considered to be important virulence factors. Among many other potentially deleterious activities, arginine-specific gingipains-R (RgpB and HRgpA) efficiently activate coagulation factors. To further expand knowledge of the interaction between gingipains and the clotting cascade, this study examined their effects on cellular components of the coagulation system. The enzymes induced an increase in intracellular calcium in human platelets at nanomolar concentrations and caused platelet aggregation with efficiency comparable to thrombin. Both effects were dependent on the proteolytic activity of the enzymes. Based on desensitization studies carried out with thrombin and peptide receptor agonists, and immunoinhibition experiments, gingipains-R appeared to be activating the protease-activated receptors, (PAR)-1 and -4, expressed on the surface of platelets. This was confirmed by the finding that HRgpA and RgpB potently activated PAR-1 and PAR-4 in transfected cells stably expressing these receptors. Cumulatively, the results indicate the existence of a novel pathway of host cell activation by bacterial proteinases through PAR cleavage. This mechanism not only represents a new trait in bacterial pathogenicity, but may also explain an emerging link between periodontitis and cardiovascular disease. (Blood. 2001;97:3790-3797)
Experimental investigation of transport and accumulation of solid particle and clay suspensions in rock samples (2015)

The results of an experimental investigation of the transport and the accumulation of the disperse phase of suspensions during its filtration through rock samples are presented. A consistent model of the inner and outer filter coke formation is considered. A method of determining the particle pick-up parameters and the permeability reduction coefficient by means of the joint modeling of the filtration experiment data and the profile of the volume concentration of the picked-up suspension particles is proposed. The methods of characterizing the colmatation zone by means of the X-ray computer microtomography and the coloring of clay particles followed by an analysis of the cleavage of the impure sample are presented. The colmatation model is generalized to cover the case in which the porous medium includes two pore continua with different properties.
Association of Blood Proteins with Large Unilamellar Liposomes (1992)

The proteins associated with liposomes in the circulation of mice were analyzed in order to determine whether bound proteins significantly influence the fate of liposomes in vivo. Liposomes were administered intravenously via the dorsal tail vein of CD1 mice and were isolated from blood after 2 min in the absence of coagulation inhibitors using a rapid “spin column” procedure. Various negatively charged liposomes exhibiting markedly different clearance properties were studied; notably, these included liposomes containing 10 mol % ganglioside GMl which has been previously shown to effectively limit liposomal uptake by the fixed macrophages of the reticuloendothelial system. The protein binding ability (PB; g of protein/mol of lipid) of the liposomes was quantitated and related to the circulation half-life (T~/~) of the liposomes. Liposomes having similar membrane surface charge imparted by different anionic phospholipids were found to exhibit markedly different protein binding potentials. Furthermore, PB values determined from the in vivo experiments were found to be inversely related to circulation half-lives. PB values in excess of 50 g of protein/ mol of lipid were observed for rapidly cleared liposomes such as those containing cardiolipin or phosphatidic acid (T~/~ 2 h) were significantly less (PB <I5 g of total protein/mol of total lipid). PB values were also determined for liposomes recovered from in vitro incubations with isolated human serum; relative PB values obtained from these in vitro experiments were in agreement with relative PB values measured from in vivo experiments. PB values, therefore, could be a useful parameter for predicting the clearance behavior of liposomes in the circulation. Liposomes exhibiting increased PB values in vivo were shown by immunoblot analysis to bind more immune opsonins, leading to a higher probability of phagocytic uptake. Finally, based on results obtained using the in vitro system, it is suggested that the mechanism by which ganglioside GM~ prolongs the murine circulation halflife of liposomes is by reducing the total amount of blood protein bound to the liposomes in a relatively nonspecific manner.
How low can you go? (2008)

We explore the extent to which newly available CPU-based security technology can reduce the Trusted Computing Base (TCB) for security-sensitive applications. We find that although this new technology represents a step in the right direction, significant performance issues remain. We offer several suggestions that leverage existing processor technology, retain security, and improve performance. Implementing these recommendations will finally allow application developers to focus exclusively on the security of their own code, enabling it to execute in isolation from the numerous vulnerabilities in the underlying layers of legacy code.
Thermal degradation of poly(p-phenylenebenzobisoxazole) and poly(p-phenylenediamine terephthalamide) fibres (2001)

This study investigates the thermal stability of poly(p-phenylenediamine-terephtalamide) (PPT) and poly(p-phenylenebenzobisoxazole) (PBO) fibres. Excellent behaviour of PBO is shown in comparison to that of PPT. The thermal stability (under pyrolytic or thermo-oxidative conditions) of PBO is 150 °C higher than that of PPT. Moreover, the strong influence of oxygen, which plays the role of an initiator of degradation, on the degradation of fibres is shown. Using the invariant kinetic parameter (IKP) method, it is shown that the degradation rate of PBO is strongly reduced in comparison with that of PPT. It provides a simulation of the ‘fuel flow’ able to feed the flames, which can explain the high fire performance of PBO compared to PPT. © 2001 Society of Chemical Industry
Regioselective cyclopentane ring formation mediated by titanocene chloride (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective cyclopentane ring formation mediated by titanocene chloridePascal Rigollier, Jonathan R. Young, Lissa A. Fowley, and John R. StilleCite this: J. Am. Chem. Soc. 1990, 112, 25, 9441–9442Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/ja00181a082https://doi.org/10.1021/ja00181a082research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left–right symmetry breaking (2021)

Proper left-right symmetry breaking is essential for animal development, and in many cases, this process is actomyosin-dependent. In <i>Caenorhabditis elegans</i> embryos active torque generation in the actomyosin layer promotes left-right symmetry breaking by driving chiral counterrotating cortical flows. While both Formins and Myosins have been implicated in left-right symmetry breaking and both can rotate actin filaments in vitro, it remains unclear whether active torques in the actomyosin cortex are generated by Formins, Myosins, or both. We combined the strength of <i>C. elegans</i> genetics with quantitative imaging and thin film, chiral active fluid theory to show that, while Non-Muscle Myosin II activity drives cortical actomyosin flows, it is permissive for chiral counterrotation and dispensable for chiral symmetry breaking of cortical flows. Instead, we find that CYK-1/Formin activation in RhoA foci is instructive for chiral counterrotation and promotes in-plane, active torque generation in the actomyosin cortex. Notably, we observe that artificially generated large active RhoA patches undergo rotations with consistent handedness in a CYK-1/Formin-dependent manner. Altogether, we conclude that CYK-1/Formin-dependent active torque generation facilitates chiral symmetry breaking of actomyosin flows and drives organismal left-right symmetry breaking in the nematode worm.