gebhart/patrepeval huggingface dataset:
Evaluation of improved articulatory codebooks and codebook access distance measures (2002)

An improved method for generating articulatory codebooks is introduced. The distance measure used for codebook access is optimized. The improvements are evaluated and compared in terms of a perceptually motivated formant distance measure. It is found that the codebooks derived from the articulatory model of P. Mermelstein (1973) are more robust against model/speaker mismatches than the codebooks derived from the model of C. Coker (1976).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Three Convolution Integrals (1987)

Previous article Next article Three Convolution IntegralsFikri KuchukFikri Kuchukhttps://doi.org/10.1137/1029120PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout"Three Convolution Integrals." SIAM Review, 29(4), pp. 632–633 Previous article Next article FiguresRelatedReferencesCited byDetails Volume 29, Issue 4| 1987SIAM Review History Published online:17 February 2012 InformationCopyright © 1987 © Society for Industrial and Applied MathematicsPDF Download Article & Publication DataArticle DOI:10.1137/1029120Article page range:pp. 632-633ISSN (print):0036-1445ISSN (online):1095-7200Publisher:Society for Industrial and Applied Mathematics
ALL-PLASTIC MANUAL-CLUTCH ACTUATION.. (2001)

SUBTITLE: ENGINEERS AT AUTOMOTIVE PRODUCTS ARE DEVELOPING THE RELATIVELY NEW MATERIAL APPLICATION FOR IMPROVED ECONOMY, SMALLER ENGINE COMPARTMENTS, AND NEW VEHICLE CONCEPTS SUCH AS HYBRIDS.
Up-Regulation of Two Distinct p53-DNA Binding Functions by Covalent Poly(ADP-ribosyl)ation: Transactivating and Single Strand Break Sensing (2013)

We used a [(32)P] p53 sequence-specific oligodeoxynucleotide and Electrophoretic-Mobility-Shift-Assays to monitor p53 DNA sequence-specific binding with p53-R267W, a nonbinding point mutant; and p53-Δ30, a deletion-mutant which lacks the carboxy-terminus that recognizes DNA-strand-breaks. Recombinant p53 and poly(ADP-ribose)polymerase-1 (PARP-1) were incubated with labeled βNAD(+) with/without DNA. The poly(ADP-ribosyl)ation of each protein increased with incubation-time and βNAD(+) and p53 concentration(s). Since p53-Δ30 was efficiently labeled, poly(ADP-ribosyl)ation target site(s) of wt-p53 must reside outside its carboxy-terminal-domain. The poly(ADP-ribosyl)ation of p53-Δ30 did not diminish its DNA binding; Instead, it enhanced DNA-sequence-specific-binding. Therefore, we conclude that DNA-sequence-specific-binding and DNA-nick-sensing of mutant-p53 are differentially regulated by poly(ADP-ribosyl)ation.
Design and analysis of a programmable single-chip architecture for DVB-T base-band receiver (2003)

This work treats the design and analysis of a programmable (or reconfigurable) DSP-domain-specific architecture called MorphoSys, upon which the world's first single-chip software solution for a DVB-T base-band receiver can be implemented. Based on the first version of MorphoSys, many modifications have been made to improve greatly both computation power and data movement efficiency. Sequential codes and SIMD codes can be parallelized; temporal granularity adjustment boosts performance up to 4 times: numerous different types of data movement can be accelerated 8 to 64 times faster than sequential movement. As a complicated (21 GOPS) and typical communication system, the DVB-T base-band receiver is designed with low performance loss and mapped onto MorphoSys architecture (>28 GOPS). This solidly contributes to software defined radio development.
Oral nucleic acid therapy using multicompartmental delivery systems (2017)

Nucleic acid‐based therapeutics has the potential for treating numerous diseases by correcting abnormal expression of specific genes. Lack of safe and efficacious delivery strategies poses a major obstacle limiting clinical advancement of nucleic acid therapeutics. Oral route of drug administration has greater delivery challenges, because the administered genes or oligonucleotides have to bypass degrading environment of the gastrointestinal ( GI ) tract in addition to overcoming other cellular barriers preventing nucleic acid delivery. For efficient oral nucleic acid delivery, vector should be such that it can protect encapsulated material during transit through the GI tract, facilitate efficient uptake and intracellular trafficking at desired target sites, along with being safe and well tolerated. In this review, we have discussed multicompartmental systems for overcoming extracellular and intracellular barriers to oral delivery of nucleic acids. A nanoparticles‐in‐microsphere oral system‐based multicompartmental system was developed and tested for in vivo gene and small interfering RNA delivery for treating colitis in mice. This system has shown efficient transgene expression or gene silencing when delivered orally along with favorable downstream anti‐inflammatory effects, when tested in a mouse model of intestinal bowel disease. WIREs Nanomed Nanobiotechnol 2018, 10:e1478. doi: 10.1002/wnan.1478 This article is categorized under: Biology‐Inspired Nanomaterials &gt; Nucleic Acid‐Based Structures Nanotechnology Approaches to Biology &gt; Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies
YANG Data Model for MPLS LDP and mLDP (2016)

This document describes a YANG data model for Multi-Protocol Label
Switching (MPLS) Label Distribution Protocol (LDP) and Multipoint LDP
(mLDP).
Transcriptome analysis in petals and leaves of chrysanthemums with different chlorophyll levels (2017)

From our transcriptome analysis, we assume that a low rate of Chl biosynthesis and a high rate of Chl degradation lead to the absence of Chls in white chrysanthemum petals. We identified several candidate transcription factors that might affect Chl accumulation in chrysanthemum petals. Functional analysis of these transcription factors will provide a basis for future molecular studies of tissue-specific Chl accumulation.
As South Confronts North (1977)

One way of looking at nations involved in the North-South confrontation is to group them as aid-givers (the industrialized rich nations) and aid-receivers (the poor Third World). Of course it is more complicated than this. Some countries of the Third World group, the Middle East oil states, are extremely rich. These played a special role in heating up the confrontation. Even among the others, not all are equally poor, but the distinction between aid-givers and aidreceivers is generally true. In fact, a great deal of the dialogue between the two groups is about how the North can more effectively assist the South in its desperate struggle to escape poverty.
Effect of the AMP-Kinase Modulators AICAR, Metformin and Compound C on Insulin Secretion of INS-1E Rat Insulinoma Cells under Standard Cell Culture Conditions (2012)

We conclude that under standard cell culture conditions the AMPK modulators AICAR and compound C, but not metformin, stimulate insulin secretion by AMPK-independent mechanisms.
Pyoverdin‐facilitated iron uptake in Pseudomonas aeruginosa: immunological characterization of the ferripyoverdin receptor (1990)

A purified polyclonal antiserum directed against the isolated main 80 kD IROMP (iron-regulated outer-membrane protein) from Pseudomonas aeruginosa PAO1 detected only the 80 kD polypeptide of outer-membrane proteins from PAO1 cells grown in iron deficiency in Western blots. It was also shown to inhibit the uptake of 59Fe pyoverdin by PAO1 cells as well as its binding to purified outer membranes. Immunofluorescence experiments with intact PAO1 cells confirmed that the receptor is present only at the surface of cells grown under conditions of iron deficiency. All these data allow us to conclude that the 80 kD main IROMP of P. aeruginosa is indeed the receptor for the siderophore ferripyoverdin.
Serum Human Epididymis Protein 4 and Risk for Ovarian Malignancy Algorithm as New Diagnostic and Prognostic Tools for Epithelial Ovarian Cancer Management (2011)

This study underlines the high specificity of HE4 in discriminating endometriosis and ovarian benign cysts from EOC and the high sensitivity of CA125 in detecting EOC. We showed HE4 and ROMA as independent prognostic factors. Multicenter studies are needed to draw firm conclusions about the applicability of HE4 and ROMA in clinical practice.
Table S1 from A Threshold of Systemic MAGE-A Gene Expression Predicting Survival in Resected Non–Small Cell Lung Cancer (2023)

&lt;p&gt;MAGE expression in NSCLC&lt;/p&gt;
Loss of the Notch effector RBPJ promotes tumorigenesis (2014)

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and consequent derepression or activation of associated gene promoters. We show here that RBPJ is frequently depleted in human tumors. Depletion of RBPJ in human cancer cell lines xenografted into immunodeficient mice resulted in activation of canonical Notch target genes, and accelerated tumor growth secondary to reduced cell death. Global analysis of activated regions of the genome, as defined by differential acetylation of histone H4 (H4ac), revealed that the cell death pathway was significantly dysregulated in RBPJ-depleted tumors. Analysis of transcription factor binding data identified several transcriptional activators that bind promoters with differential H4ac in RBPJ-depleted cells. Functional studies demonstrated that NF-κB and MYC were essential for survival of RBPJ-depleted cells. Thus, loss of RBPJ derepresses target gene promoters, allowing Notch-independent activation by alternate transcription factors that promote tumorigenesis.
Measurement of electrons from semileptonic heavy-flavour hadron decays at midrapidity in pp and Pb–Pb collisions at sNN=5.02 TeV (2020)

The differential invariant yield as a function of transverse momentum (pT) of electrons from semileptonic heavy-flavour hadron decays was measured at midrapidity in central (0–10%), semi-central (30–50%) and peripheral (60–80%) lead–lead (Pb–Pb) collisions at √sNN=5.02 TeV in the pTintervals 0.5–26 GeV/c(0–10% and 30–50%) and 0.5–10 GeV/c(60–80%). The production cross section in proton–proton (pp) collisions at √s=5.02 TeV was measured as well in 0.5 &amp;lt;10 GeV/cand it lies close to the upper band of perturbative QCD calculation uncertainties up to pT=5 GeV/cand close to the mean value for largerpT. The modification of the electron yield with respect to what is expected for an incoherent superposition of nucleon–nucleon collisions is evaluated by measuring the nuclear modification factorRAA. The measurement of the RAAin different centrality classes allows in-medium energy loss of charm and beauty quarks to be investigated. The RAAshows a suppression with respect to unity at intermediate pT, which increases while moving towards more central collisions. Moreover, the measured RAAis sensitive to the modification of the parton distribution functions (PDF) in nuclei, like nuclear shadowing, which causes a suppression of the heavy-quark production at low pTin heavy-ion collisions at LHC.
Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane (2007)

Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as ICRF-187) has been used in the clinic as a cardioprotectant against doxorubicin cardiotoxicity. The molecular basis for doxorubicin cardiotoxicity and the cardioprotective effect of dexrazoxane, however, is not fully understood. In the present study, we showed that dexrazoxane specifically abolished the DNA damage signal gamma-H2AX induced by doxorubicin, but not camptothecin or hydrogen peroxide, in H9C2 cardiomyocytes. Doxorubicin-induced DNA damage was also specifically abolished by the proteasome inhibitors bortezomib and MG132 and much reduced in top2beta(-/-) mouse embryonic fibroblasts (MEF) compared with TOP2beta(+/+) MEFs, suggesting the involvement of proteasome and DNA topoisomerase IIbeta (Top2beta). Furthermore, in addition to antagonizing Top2 cleavage complex formation, dexrazoxane also induced rapid degradation of Top2beta, which paralleled the reduction of doxorubicin-induced DNA damage. Together, our results suggest that dexrazoxane antagonizes doxorubicin-induced DNA damage through its interference with Top2beta, which could implicate Top2beta in doxorubicin cardiotoxicity. The specific involvement of proteasome and Top2beta in doxorubicin-induced DNA damage is consistent with a model in which proteasomal processing of doxorubicin-induced Top2beta-DNA covalent complexes exposes the Top2beta-concealed DNA double-strand breaks.
Figure S4 from Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer (2023)

&lt;p&gt;Chemoresistant mouse model&lt;/p&gt;
Alkylation and aldol condensation reactions of 1,3-oxathiolanones (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation and aldol condensation reactions of 1,3-oxathiolanonesJohn M. McIntosh, Pratibha Mishra, and Maqbool A. SiddiquiCite this: J. Org. Chem. 1984, 49, 6, 1036–1040Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/jo00180a016https://doi.org/10.1021/jo00180a016research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genetic Sensor for Strong Methylating Compounds (2013)

Methylating chemicals are common in industry and agriculture and are often toxic, partly due to their propensity to methylate DNA. The Escherichia coli Ada protein detects methylating compounds by sensing aberrant methyl adducts on the phosphoester backbone of DNA. We characterize this system as a genetic sensor and engineer it to lower the detection threshold. By overexpressing Ada from a plasmid, we improve the sensor’s dynamic range to 350-fold induction and lower its detection threshold to 40 μM for methyl iodide. In eukaryotes, there is no known sensor of methyl adducts on the phosphoester backbone of DNA. By fusing the N-terminal domain of Ada to the Gal4 transcriptional activation domain, we built a functional sensor for methyl phosphotriester adducts in Saccharomyces cerevisiae. This sensor can be tuned to variable specifications by altering the expression level of the chimeric sensor and changing the number of Ada operators upstream of the Gal4-sensitive reporter promoter. These changes result in a detection threshold of 28 μM and 5.2-fold induction in response to methyl iodide. When the yeast sensor is exposed to different SN1 and SN2 alkylating compounds, its response profile is similar to that observed for the native Ada protein in E. coli, indicating that its native function is retained in yeast. Finally, we demonstrate that the specifications achieved for the yeast sensor are suitable for detecting methylating compounds at relevant concentrations in environmental samples. This work demonstrates the movement of a sensor from a prokaryotic to eukaryotic system and its rational tuning to achieve desired specifications.
Wafer Level Package for MEMS with TSVs and Hermetic Seal (2011)

In recent years, downsizing of MEMS package and high accuracy MEMS device mounting have been strongly required from expanding applications that using MEMS not only for industrial and automobile but also for consumer typified mobile phone. In order to achieve that, it is appropriate to use Silicon package that can be mounted at wafer level packaging. Silicon package is made of monocrystal silicon wafer. The deep cavity is fabricated on monocrystal silicon wafer by Wet or Dry etching. And MEMS device can be mounted on the cavity. The electrical connecting between front side and back side of cavity portion is achieved by TSVs that located on the bottom of cavity. Hermetic seal can be achieved by using glass or silicon wafer bonding method. By using a driver device wafer (before dicing) as the cap for hermetic seal, smaller size and smaller number of parts module can be fabricated. In this report, methods and designs for hermetic seal with wafer level process were examined. Methods that applied were polyimide adhesive bonding, anodic bonding and Au-In solder bonding. Location of TSVs on the bottom of cavity and thickness of diaphragm with TSVs was also examined. Silicon package for piezo type gyro MEMS that designed by the result of evaluation was fabricated. This package used optimized Au-In solder bonding for hermetic seal and optimized location of TSVs for interconnection. That was designed over 50% thinner than conventional ceramic packages. Characteristics of hermetic seal were evaluated by Q factor of gyro MEMS that mounted inside of the silicon package. It is confirmed that performance of sealing are good enough for running of the MEMS.
Modulation of Characteristics of a Ruthenium‐Coordinated Flavin Analogue That Shows an Unusual Coordination Mode (2007)

Hallo− hallo−! A ruthenium(II) complex (1) with the flavin analogue alloxazine (H2allo) has revealed that the ligand anion (Hallo−) forms a four-membered chelate ring. This unprecedented coordination mode of Hallo allows it to form hydrogen bonds with a complementary receptor (e.g. 2), allowing the effects of hydrogen bonding on the redox behavior and electronic structure of a ruthenium-bound Hallo radical to be studied. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604028_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Surface and bulk phase separation in block copolymers and their blends. Polysulfone/polysiloxane (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface and bulk phase separation in block copolymers and their blends. Polysulfone/polysiloxaneNiranjan M. Patel, David W. Dwight, James L. Hedrick, Dean C. Webster, and James E. McGrathCite this: Macromolecules 1988, 21, 9, 2689–2696Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ma00187a007https://doi.org/10.1021/ma00187a007research-articleACS PublicationsRequest reuse permissionsArticle Views901Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hepatitis B Markers in United States Drug Addicts with Special Emphasis on the Delta Hepatitis Virus (1984)

Hepatitis B virus and hepatitis delta virus co-infection in drug addicts has been well described in Europe, the latter agent appearing to have been introduced there in the mid-1970's. Currently, similar data are scanty among United States addicts. We therefore reevaluated 99 drug addicts from three different geographic locations in the United States who had participated in a Veterans Administration Cooperative Study between 1972 and 1975. Almost all were asymptomatic, and all had been subjected to liver biopsy because of prolonged aminotransferase abnormalities. Stored sera were tested for antibody to hepatitis delta antigen (anti-HD) by radioimmunoassay and available liver biopsies examined for hepatitis delta antigen (HDAg) by immunofluorescence. Overall, 19.2% were HBsAg positive, 9.1% HBeAg positive, 90% anti-HBc positive and 10.1%, positive for anti-HD. Anti-HD was identified in 42.1% of addicts who were HBsAg positive and in 3.3% who were anti-HBs positive. No correlation was found between HBeAg and anti-HD, but anti-HD was present significantly more frequently in those with chronic active hepatitis than in those with chronic persistent hepatitis. We conclude that hepatitis delta virus infection is common in HBsAg-positive drug addicts in the United States dating back to at least 1972 and probably earlier.
Interface Controls Spontaneous Crystallization in Thin Films of the Ionic Liquid [C2C1Im][OTf] on Atomically Clean Pd(111) (2014)

A total of 5-30 monolayer thick films of the ionic liquid (IL) [C2C1Im][OTf] were vaporized in vacuo onto an atomically clean Pd(111) single crystal surface at 220 K. Time- and temperature-resolved infrared reflection-absorption spectroscopy reveals growth, interactions with the metallic support, and the macroscopic phase behavior of the layer. At 220 K, the IL layer first grows in the form of a glassy phase. Crystallization of the IL was witnessed above a critical thickness of about 10 monolayers. On the basis of the known bulk crystal structure of the IL, we suggest the formation of well-oriented checkerboard-like crystalline film structures on the surface. The preferential orientation manifested by the crystal phase with regard to the macroscopic metallic surface is attributed to strong interactions between anionic headgroups and the metal.