gebhart/patrepeval huggingface dataset:
Consequence of phosphorus stereochemistry upon the postinhibitory reaction kinetics of acetylcholinesterase poisoned by phosphorothiolates (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConsequence of phosphorus stereochemistry upon the postinhibitory reaction kinetics of acetylcholinesterase poisoned by phosphorothiolatesCharles M. Thompson, Seungmin Ryu, and Clifford E. BerkmanCite this: J. Am. Chem. Soc. 1992, 114, 27, 10710–10715Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://doi.org/10.1021/ja00053a005RIGHTS & PERMISSIONSArticle Views152Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (837 KB) Get e-Alerts Get e-Alerts
Endwall Performance of Outlet Guide Vane Cascades With Different Blade Loading Distributions (2008)

As a part of an innovative aerodynamic design concept for a single stage low pressure turbine, a high turning outlet guide vane is required to remove the swirl from the hot gas. The airfoil of the vane is a highly loaded compressor airfoil that has to operate at very low Reynolds numbers (Re∼120,000). Recently published numerical design studies and experimental analysis on alternatively designed airfoils showed that blade profiles with an extreme front loaded pressure distribution are advantageous for low Reynolds number conditions. This paper experimentally and numerically discusses about the three-dimensional performance near the end-wall of two alternatively designed cascades, the end-wall performance of a baseline cascade with controlled diffusion airfoils (CDA) and a cascade with extreme front loaded airfoils. The results showed that although the end-wall pressure gradients are different, the characteristics of the secondary flow are very similar for both of the cascades. Both, experiment and numerical analysis showed that the losses close to the end-wall of the extreme front loaded airfoils are even lower in relation to those of the CDA airfoils. The flow mechanism on the superiority of the extreme front loaded airfoils around the end-wall region is discussed.
Identification of an immunotherapy-responsive molecular subtype of bladder cancer (2019)

Background: Although various molecular subtypes of bladder cancer (BC) have been investigated, most of these studies have focused on muscle-invasive BC (MIBC). A few studies have investigated non-muscle-invasive BC (NMIBC) or NMIBC and MIBC together, but none has classified progressive NMIBC or immune checkpoint inhibitor (ICI)-based therapeutic responses in early-stage BC patients. Methods: A total of 1,934 samples from seven patient cohorts were used. We performed unsupervised hierarchical clustering to stratify patients into distinct subgroups and constructed a classifier by applying SAM/ PAM algorithms. We then investigated the association between molecular subtypes and immunotherapy responsiveness using various statistical methods. Findings: We explored large-scale genomic datasets encompassing NMIBC and MIBC, redefining four distinct molecular subtypes, including a subgroup containing progressive NMIBC and MIBC with poor prognosis that would benefit from ICI treatment. This subgroup showed poor progression-free survival with the distinct features of high mutation load, activated cell cycle, and inhibited TGFb signalling. Importantly, we verified that BC patients with this subtype were significantly responsive to an anti-PD-L1 agent in the IMvigor210 cohort. Interpretation: Our results reveal an immunotherapeutic option for ICI treatment of highly progressive NMIBC and MIBC with poor prognosis.
Dynamic optical tomography: resolution and contrast enhancement by frequency-filtering (2003)

We demonstrate the capacity to significantly enhance the resolution and contrast of internal structures imaged by dynamic optical tomography. We recognize that the presence of time-harmonic behavior (e.g., vasomotion), permits use of simple feature-extraction protocols capable of producing a high-contrast image. Results obtained from numerical simulation of a medium experiencing localized spatial harmonic behavior showed that target contrast could be improved by a factor of 40, accompanied by a marked improvement in resolution.
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia (2014)

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis. In the extracellular compartment, it exhibits cytokine-/adipokinelike properties, suggesting that it stands at the crossroad between metabolism and inflammation. Here we show that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic leukemia (CLL) patients. The extracellular form (eNAMPT) is produced by CLL lymphocytes upon B-cell receptor, Toll-like receptor, and nuclear factor κB (NF-κB) signaling pathway activation. eNAMPT is important for differentiation of resting monocytes, polarizing them toward tumor-supporting M2 macrophages. These cells express high levels of CD163, CD206, and indoleamine 2,3-dioxygenase and secrete immunosuppressive (interleukin [IL] 10, CC chemokine ligand 18) and tumor-promoting (IL-6, IL-8) cytokines. NAMPT-primed M2 macrophages activate extracellular-regulated kinase 1/2, signal transducer and activator of transcription 3, and NF-κB signaling; promote leukemic cell survival; and reduce T-cell responses. These effects are independent of the enzymatic activity of NAMPT, as inferred from the use of an enzymatically inactive mutant. Overall, these results reveal that eNAMPT is a critical element in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.
Relationship between Transport of Bacteria and Their Clogging Efficiency in Sand Columns (1992)

In an earlier article, we reported that, under conditions in which neither exopolymers nor bacterial mats were produced, Arthrobacter sp. strain AK19 was an effective plugging agent in sand columns, whereas the bacterial strain SLI had no significant effect on the permeability of the medium. A laboratory experiment with sand columns was carried out to elucidate the causes of this difference in behavior. Measured values of the saturated hydraulic conductivity of the sand were explained in terms of biomass accumulation, which was estimated by solving a mass balance equation. The relationship between the saturated hydraulic conductivity and the biomass density within the sand was exponential, although two different exponential coefficients were needed to fit the data for biomass densities above or below 13 mg (wet weight) per cm, suggesting that two different clogging mechanisms may be involved in different ranges of biomass densities. The experimental results suggest that the SLI strain was a poor clogging agent partly because of its lower yield coefficient relative to the limiting nutrient (oxygen) and partly because 60% of the biomass produced in situ was washed out from the column, compared with only 1.2% in the case of Arthrobacter sp. strain AK19.
Short-pulse optical parametric chirped-pulse amplification for the generation of high-power few-cycle pulses (2007)

This paper demonstrates ultrabroadband optical parametric chirped-pulse amplification (OPCPA) with 100-fs pulses in the 100-muJ range. By using OPA for amplifying mainly the weak part of the filament-broadened spectrum much shorter pulses with an improved uniformity of the spectral intensity can be achieved as compared to the direct compression of the filament output. In order to increase the signal pulse energy to the multi-mJ level an improved spatial filter using a tapered glass capillary pinhole is under construction to allow for using a much larger part of the ATLAS output energy for pumping. Furthermore, the high available seed energy of 1 mJ could allow for reaching the 100 mJ level with small amplification factors in a multi-stage OPCPA system where saturation in all stages is beneficial for signal stability and pulse contrast. Scaling of the short-pulse OPCPA scheme to petawatt level is also planned.
Material Structure Design of Stress-Dependent Adaptive Stiffness (2001)

Use of functional material is a primitive and most promising approach to the functional structural system, e.g. adaptive/smart structures. It, however, is not always necessary for a certain aspect of such structural function. This study proposes a material structure design approach to the stress-dependent anisotropic adaptive stiffness by using the conventional linear elastic material of isotropy. The structural design problem has been formulated for the material structure consisting of mesoscopic unit cells and solved by using the simple isotropic material with penalization (SIMP) method for the topology design and the traction method for the geometry design for microstructure of the unit cell. The effectiveness of the proposed idea has been examined through numerical studies in two-dimensional cases.
The human corpus luteum secretes 5α-pregnane-3,20-dione (1986)

A radioimmunoassay for 5 alpha-pregnane-3,20-dione (5 alpha-DHP) in plasma is described. The concentration of 5 alpha-DHP in peripheral plasma during the follicular phase of the menstrual cycle was of the same order of magnitude as that of progesterone (P). During the luteal phase, the plasma 5 alpha-DHP was 8-fold higher than in the follicular phase and about 1/3 of the P concentration. The concentration of 5 alpha-DHP in ovarian venous plasma draining an ovary containing the corpus luteum was 22-fold higher than the concentration in plasma from the contralateral ovarian vein. These results show that the corpus luteum secretes significant amounts of 5 alpha-DHP.
A subjective experiment for 3D-mesh segmentation evaluation (2010)

In this paper we present a subjective quality assessment experiment for 3D-mesh segmentation. For this end, we carefully designed a protocol with respect to several factors namely the rendering conditions, the possible interactions, the rating range, and the number of human subjects. To carry out the subjective experiment, more than 40 human observers have rated a set of 250 segmentation results issued from various algorithms. The obtained Mean Opinion Scores, which represent the human subjects' point of view toward the quality of each segmentation, have then been used to evaluate both the quality of automatic segmentation algorithms and the quality of similarity metrics used in recent mesh segmentation benchmarking systems.
Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses (2010)

Glutamate is the major excitatory neurotransmitter in the brain. The NMDA subtype of glutamate receptors (NMDAR) is known to mediate many physiological neural functions. However, excessive activation of NMDARs contributes to neuronal damage in various acute and chronic neurological disorders. To avoid unwanted adverse side effects, blockade of excessive NMDAR activity must therefore be achieved without affecting its physiological function. Memantine, an adamantane derivative, has been used for the treatment of Alzheimer's disease with an excellent clinical safety profile. We previously showed that memantine preferentially blocked neurotoxicity mediated by excessive NMDAR activity while relatively sparing normal neurotransmission, in part because of its uncompetitive antagonism with a fast off-rate. Here, using rat autaptic hippocampal microcultures, we show that memantine at therapeutic concentrations (1-10 microM) preferentially blocks extrasynaptic rather than synaptic currents mediated by NMDARs in the same neuron. We found that memantine blocks extrasynaptic NMDAR-mediated currents induced by bath application of 100 microM NMDA/10 microM glycine with a twofold higher potency than its blockade of the NMDAR component of evoked EPSCs (EPSCs(NMDAR)); this effect persists under conditions of pathological depolarization in the presence of 1 mm extracellular Mg(2+). Thus, our findings provide the first unequivocal evidence to explain the tolerability of memantine based on differential extrasynaptic/synaptic receptor blockade. At therapeutic concentrations, memantine effectively blocks excessive extrasynaptic NMDAR-mediated currents, while relatively sparing normal synaptic activity.
A complex valued Hebbian learning algorithm (2002)

We present a training rule for a single-layered linear network with complex valued weights and activation levels. This network can be used to extract the principal components of a complex valued data set. We also introduce a new training method that reduces the training time of the complex valued as well as of the real valued network. The use of the new network and training algorithm is illustrated with a problem of compressing images represented in the spectral domain.
Impact of Degradation of Polyethylene Particles on Their Cytotoxicity (2023)

Microplastics are ubiquitous in the environment, including in the ocean, soil, and air. Therefore, there are concerns regarding human exposure. Since it is known that the surface of microplastics in various environments is chemically deteriorated by external factors such as ultraviolet rays and waves, it is essential to evaluate the biological effects of degraded microplastics. In this study, we experimented by accelerating the degradation of polyethylene (PE) using vacuum ultraviolet light and prepared PE samples with different degrees of degradation. Then, we evaluated the effects of undegraded and variously degraded PE on cells using cytotoxicity tests. Based on the cytotoxicity test results, we saw a tendency for increased cytotoxicity with increasing degradation. Therefore, this study substantially links the deterioration of microplastics with their biological effects.
Fast rates for empirical risk minimization over c\\`adl\\`ag functions\n with bounded sectional variation norm (2019)

Empirical risk minimization over classes functions that are bounded for some\nversion of the variation norm has a long history, starting with Total Variation\nDenoising (Rudin et al., 1992), and has been considered by several recent\narticles, in particular Fang et al., 2019 and van der Laan, 2015. In this\narticle, we consider empirical risk minimization over the class $\\mathcal{F}_d$\nof c\\`adl\\`ag functions over $[0,1]^d$ with bounded sectional variation norm\n(also called Hardy-Krause variation).\n We show how a certain representation of functions in $\\mathcal{F}_d$ allows\nto bound the bracketing entropy of sieves of $\\mathcal{F}_d$, and therefore\nderive rates of convergence in nonparametric function estimation. Specifically,\nfor sieves whose growth is controlled by some rate $a_n$, we show that the\nempirical risk minimizer has rate of convergence $O_P(n^{-1/3} (\\log\nn)^{2(d-1)/3} a_n)$. Remarkably, the dimension only affects the rate in $n$\nthrough the logarithmic factor, making this method especially appropriate for\nhigh dimensional problems.\n In particular, we show that in the case of nonparametric regression over\nsieves of c\\`adl\\`ag functions with bounded sectional variation norm, this\nupper bound on the rate of convergence holds for least-squares estimators,\nunder the random design, sub-exponential errors setting.\n
Construction of engineered bifunctional enzymes and their overproduction in Aspergillus niger for improved enzymatic tools to degrade agricultural by-products (2005)

International audience
Fabrication of Oxide Ceramics Composite by Reactive Infiltration Process (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Plasma Cell Myeloma and Related Disorders (2018)

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Biological activity and disease controlling efficacy of penthiopyrad (2013)

Various carboxamide derivatives were synthesized, and the fungicidal activity was evaluated by both in vitro and in vivo experiments to find out the best compound for a fungicide. Penthiopyrad is unique in its wide fungicidal spectrum. The introduction of a thiophene ring with hydrophobic branched alkyl groups brought broad-spectrum fungicidal activity leading to the discovery of penthiopyrad, N-[2-(1,3-dimethylbutyl)-3-thienyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide. Of the carboxamide fungicides, carboxin is particularly effective for controlling the diseases caused by basidiomycetous fungi, including smut and bunt of cereals, but it is not as effective against others that are easily controlled by boscalid, which is not so effective against basidiomycetes pathogens. Penthiopyrad covers the effect gap between carboxin and boscalid. In this report, we have focused on the biological properties revealed in laboratory tests and small pot tests in the greenhouse.
Author Correction: IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria (2021)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Circuit quantum electrodynamics (cQED) with modular quasi-lumped models (2021)

Extracting the Hamiltonian of interacting quantum-information processing systems is a keystone problem in the realization of complex phenomena and large-scale quantum computers. The remarkable growth of the field increasingly requires precise, widely-applicable, and modular methods that can model the quantum electrodynamics of the physical circuits, and even of their more-subtle renormalization effects. Here, we present a computationally-efficient method satisfying these criteria. The method partitions a quantum device into compact lumped or quasi-distributed cells. Each is first simulated individually. The composite system is then reduced and mapped to a set of simple subsystem building blocks and their pairwise interactions. The method operates within the quasi-lumped approximation and, with no further approximation, systematically accounts for constraints, couplings, parameter renormalizations, and non-perturbative loading effects. We experimentally validate the method on large-scale, state-of-the-art superconducting quantum processors. We find that the full method improves the experimental agreement by a factor of two over taking standard coupling approximations when tested on the most sensitive and dressed Hamiltonian parameters of the measured devices.
Quantitative Magnetization Transfer Imaging in Acute Stroke: A Follow Up Study Correlating Quantitative MRI with Respect of Severity of Stroke (2010)

Magnetisation transfer (MT) imaging can potentially serve as a marker for loss of tissue integrity. Moreover increased pathologic specificity is expected from quantitative MT (qMT) as compared to the assessment of the semi-quantitative MT ratio (MTR) images only. Here, we present an evaluation of qMTI data over three consecutive MRIs within the first 10 days for patients suffering from middle cerebral artery stroke with different progression of symptoms. Results seem to be superior to simple MTR measurements and possibly allow for early statement of prognosis and efficacy of therapeutic methods.
Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma (2021)

We generated dual-antigen receptor (DR) T cells from induced pluripotent stem cells (iPSCs) to mitigate tumor antigen escape. These cells were engineered to express a chimeric antigen receptor (CAR) for the antigen cell surface latent membrane protein 1 (LMP1; LMP1-CAR) and a T cell receptor directed to cell surface latent membrane protein 2 (LMP2), in association with human leucocyte antigen A24, to treat therapy-refractory Epstein-Barr virus-associated lymphomas. We introduced LMP1-CAR into iPSCs derived from LMP2-specific cytotoxic T lymphocytes (CTLs) to generate rejuvenated CTLs (rejTs) active against LMP1 and LMP2, or DRrejTs. All DRrejT-treated mice survived >100 days. Furthermore, DRrejTs rejected follow-up inocula of lymphoma cells, demonstrating that DRrejTs persisted long-term. We also demonstrated that DRrejTs targeting CD19 and LMP2 antigens exhibited a robust tumor suppressive effect and conferred a clear survival advantage. Co-operative antitumor effect and in vivo persistence, with unlimited availability of DRrejT therapy, will provide powerful and sustainable T cell immunotherapy.
Anti-inflammatory activity of Tetragronula species from Indonesia (2018)

Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory drugs (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and anti-inflammatory effects. In this study, we investigated the bioactive compound and <i>in vivo</i> anti-inflammatory properties of both smooth and rough propolis from <i>Tetragronula sp</i>. To further identify anti-inflammatory markers in propolis, LC-MS/MS was used, and results were analyzed by Mass Lynx 4.1. Rough and smooth propolis of <i>Tetragonula sp</i>. were microcapsulated with maltodextrin and arabic gum. Propolis microcapsules at dose 25-200 mg/kg were applied for carrageenan-induced rat's paw-inflammation model. Data were analyzed by one-way ANOVA and Kruskal-Wallis statistical tests. LC-MS/MS experiments identified seven anti-inflammatory compounds, including [6]-dehydrogingerdione, alpha-tocopherol succinate, adhyperforin, 6-epiangustifolin, deoxypodophyllotoxin, kurarinone, and xanthoxyletin. Our results indicated that smooth propolis at 50 mg/kg inhibited inflammation to the greatest extent, followed by rough propolis at a dose of 25 mg/kg. SPM and RPM with the dose of 25 mg/kg had inflammatory inhibition value of 62.24% and 58.12%, respectively, which is comparable with the value 70.26% of sodium diclofenac with the dose of 135 mg/kg. This study suggests that propolis has the potential candidate to develop as a non-steroid anti-inflammatory drug.