gebhart/patrepeval huggingface dataset:
Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice (2020)

Abstract The peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α) is known as a transcriptional co-activator in peripheral tissues but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including transcripts derived from a novel promoter about ∼580 Kb upstream from the reference gene. These isoforms incorporate repetitive sequences from the simple sequence repeat (SSR) and short interspersed nuclear element (SINE) classes and are predicted to give rise to proteins with distinct amino-termini. In this study, we show that a SINE-containing isoform is the predominant form of Pgc1α expressed in neurons. We then generated a mouse carrying a mutation within the SINE to study its functional role in the brain. By combining genomics, biochemical and behavioural approaches, we show that this mutation leads to impaired motor coordination in females, but not male mice, associated with the upregulation of hundreds of cerebellar genes. Moreover, our analysis suggests that known nuclear receptors interact with this isoform of PGC1α in the brain to carry out the female transcriptional program. These data expand our knowledge on the role of Pgc1α in the brain and help explain its conflicting roles in neurological disease and behavioural outcomes.
Relationship Between Delay in Performing Direct Coronary Angioplasty and Early Clinical Outcome in Patients With Acute Myocardial Infarction (1999)

The time to treatment with direct PTCA, as with thrombolytic therapy, is a critical determinant of mortality.
Characterization of a-C:H:N deposition from CH4/N2 rf plasmas using optical emission spectroscopy (1996)

Optical emission spectra (OES) from CH4/N2 rf plasmas, which are used for the deposition of nitrogen-containing hydrogenated amorphous carbon (a-C:H:N) thin films, have been characterized. Previously unidentified spectral lines have been assigned to atomic N. Further identified species include CH, H, H2, N2, N+2, N, and CN. Variations between spectra from the pure CH4 or N2 plasmas and the mixed CH4/N2 plasma are discussed. The enhancement of excited nitrogen species, with the addition CH4, is attributed to Penning ionization. The observed OES variations of the CH4/N2 plasma with power, pressure, and CH4/N2 ratio are explained in terms of possible reaction mechanisms and their activation, and correlated with preliminary film growth characteristics.
Improved detection of global copy number variation using high density, non-polymorphic oligonucleotide probes (2008)

Using a well-characterized pair of DNA samples, close to 200 CNVs were identified, of which nearly 50% appear novel yet were independently validated using quantitative PCR. The results indicate that non-polymorphic probes provide a robust approach for CNV identification, and the increasing precision of CNV boundary delineation should allow a more complete analysis of their genomic organization.
Radiation administered as a large single dose or in a fractionated schedule: Role of the tumour vasculature as a target for influencing response (2006)

This study was designed to demonstrate a differential tumour response to radiation given as a large single dose or fractionated, and to investigate the postulated role of the tumour vasculature as a target for this difference. A C3H mammary carcinoma grown in the right rear foot of female CDF1 mice was used when at 200 mm3. Radiation (240 kV x-rays) was given locally to the tumour bearing foot either as 1 x 20 Gy or 10 x 2 Gy (2 fractions/day). Tumour response was assessed by calculating tumour growth time (TGT; time to grow to 3 times treatment volume). Vascular effects were monitored by performing dynamic contrast enhanced-magnetic resonance imaging using a 3-Tesla magnet and the contrast agent gadolinium (Gd)-DTPA. The endpoint was the initial area under the concentration curve (IAUC) following Gd-DTPA. The mean (+/-1 S.E.) TGT for control mice was 4.0 days (+/-0.2). This was significantly (Student's t-test; p < 0.05) increased to 12.9 (+/-0.6) and 19.8 (+/-0.7) days, by 10 x 2 and 1 x 20 Gy, respectively. The mean (+/-1 S.E.) of the median IAUC values for control tumours was 8.4 mMs (+/-0.5). This was non-significantly increased to 9.4 mMs (+/-0.4) 6-hours after 1 x 20 Gy, but then significantly decreased to a nadir of 6.8 mMs (+/-0.5) after 48-hours. IAUC recovered at longer time intervals. With 10 x 2 Gy, IAUC significantly decreased during irradiation, reaching 6.7 (+/-0.3) and 5.6 (+/-0.3) mMs at the mid-point and end of the irradiation period, respectively. IAUC recovered 24-hours after irradiating before significantly decreasing to 4.4 mMs (+/-0.3) at 48-hours. Our results confirm that radiation given in a large single dose is superior to the same dose given in a more conventional fractionated schedule, but vascular-mediated effects did not account for this difference in radiation sensitivity.
VeriNet Web-speaker verification for the World Wide Web (2002)

VeriNet Web is a software system that allows Web site resources to be protected using speaker verification. Speaker verification is the most practical biometric technology available for Internet security since the required collection hardware is readily available on most personal computers (PCs) being distributed today. VeriNet Web employs a three-tier client server architecture that distributes verification processing across multiple components. It integrates into a Web application by supplying standard extensions to a commercial Web server and browser. These components work together to manage the authentication process, maintain a user's authentication status, and ensure that protected resources are only accessed by authenticated users. When developing this multimedia Internet application, there were numerous implementation issues regarding the user interface, secure data transmissions, and user PC configuration that affected the success of the system. The paper discusses these issues. In addition, the paper examines the verification performance of VeriNet Web for a trial conducted with company employees. For experiments in this environment, the system yielded very good performance, and the equal error rate was always less than 5%.
310: Antiangiogenic Gene Therapy for Metastatic Renal Cell Carcinoma Produces Tumor Growth Suppression in an Athymic Nude Mouse Model (2007)

You have accessJournal of UrologyPodium 10, Sunday, May 20, 2007 10:00 am - 12:00 pm1 Apr 2007310: Antiangiogenic Gene Therapy for Metastatic Renal Cell Carcinoma Produces Tumor Growth Suppression in an Athymic Nude Mouse Model Matthew J. Mellon, Miwon Ahn, Yan-Ping Zhang, Juan A. Jiménez, Chinghai Kao, and Thomas A. Gardner Matthew J. MellonMatthew J. Mellon More articles by this author , Miwon AhnMiwon Ahn More articles by this author , Yan-Ping ZhangYan-Ping Zhang More articles by this author , Juan A. JiménezJuan A. Jiménez More articles by this author , Chinghai KaoChinghai Kao More articles by this author , and Thomas A. GardnerThomas A. Gardner More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30575-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "310: Antiangiogenic Gene Therapy for Metastatic Renal Cell Carcinoma Produces Tumor Growth Suppression in an Athymic Nude Mouse Model." The Journal of Urology, 177(4S), p. 104 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 104 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Matthew J. Mellon More articles by this author Miwon Ahn More articles by this author Yan-Ping Zhang More articles by this author Juan A. Jiménez More articles by this author Chinghai Kao More articles by this author Thomas A. Gardner More articles by this author Expand All Advertisement Loading ...
Individualized Models for Glucose Prediction in Type 1 Diabetes: Comparing Black-Box Approaches to a Physiological White-Box One (2023)

Black-box strategies remain preferable for glucose prediction even when compared to a white-box model with sound physiological structure and individualized parameters.
Tissue Oxygen Saturation and Outcome after Cardiac Surgery (2011)

In patients undergoing cardiac surgery, reduced tissue oxygen saturation in the thenar eminence may be associated with poor postoperative outcome. Further studies are needed to confirm these findings and to determine whether measures to improve the balance between oxygen delivery and consumption might improve both tissue oxygen saturation and outcome.
Analysis of the Heat-Affected Zone and Ablation Efficiency in Terms of Burst Mode Parameters During High Power Picosecond Laser Micromachining of Metals (2022)

Abstract The past decade has seen a significantly increased use of high-power ultrafast lasers in micromachining applications. With the continual increase of the laser power for ultrafast lasers, an increase in the ablation rate has been brought about. However, it also created some negative effects, such as the heat-affected zone (HAZ) and thermal damages, which hardly occur at lower power. This issue was reported in the literature but has not been systematically addressed by previous research. This paper presents a systematic study on using the burst mode ablation to limit the HAZ while maintaining a high ablation efficiency using a high-power industrial picosecond laser with burst fluence larger than 10 J/cm2. An extended three-dimensional two-temperature model (3D-TTM) was employed to study the mechanism of the HAZ development and to predict the ablation efficiency with experimental validation. The essentiality of including the lattice heat conduction to predict accurate HAZ was discussed. The effect of the number of pulses per burst and pulse to pulse separation time was investigated. The optimal number of pulses per burst was obtained by using the 3D-TTM for copper and stainless steel. The 3D-TTM suggested that by using the optimal number of pulses per burst, a maximum reduction of 77% and 61% in HAZ could be achieved for copper and stainless steel respectively. And the corresponding ablation efficiency will be increased by 24% and 163% for copper and stainless steel at the same time. This study showed that burst mode laser machining at high fluence is an effective way of increasing efficiency while limiting the HAZ.
A monolithically integrated In/sub 0.53/Ga/sub 0.47/As optical receiver with voltage-tunable transimpedance (1991)

The authors report the fabrication and performance of the first monolithically integrated In/sub 0.53/Ga/sub 0.47/As receiver with voltage-tunable transimpedance. In this receiver, a SiN/sub x/ passivated p-i-n diode is integrated with an In/sub 0.53/Ga/sub 0.47/As transimpedance amplifier using multiple-etched steps to assist lithography and step coverage of the interconnection metallization. The p-i-n diode has an external quantum efficiency of 82% at a wavelength of 1.3 mu m and -5 V bias. Adjusting the gate bias of a narrow-gate feedback transistor gives the receiver a tunable transimpedance of 19-36 Omega , a responsivity of 17-30 kV/W, and an unequalized bandwidth of 90-130 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study (2022)

Persistent abnormalities in microcirculatory function are associated with poor clinical outcomes in patients with circulatory shock. We sought to identify patients with acutely reversible microcirculatory dysfunction using a low-dose topical nitroglycerin solution and handheld videomicroscopy during circulatory shock after cardiac surgery. Forty subjects were enrolled for the study, including 20 preoperative control and 20 post-operative patients with shock. To test whether microcirculatory dysfunction is acutely reversible during shock, the sublingual microcirculation was imaged with incident dark field microscopy before and after the application of 0.1 mL of a 1% nitroglycerin solution (1 mg/mL). Compared to the control group, patients with shock had a higher microcirculation heterogeneity index (MHI 0.33 vs. 0.12, p < 0.001) and a lower microvascular flow index (MFI 2.57 vs. 2.91, p < 0.001), total vessel density (TVD 22.47 vs. 25.90 mm/mm<sup>2</sup>, p = 0.005), proportion of perfused vessels (PPV 90.76 vs. 95.89%, p < 0.001) and perfused vessel density (PVD 20.44 vs. 24.81 mm/mm<sup>2</sup>, p < 0.001). After the nitroglycerin challenge, patients with shock had an increase in MFI (2.57 vs. 2.97, p < 0.001), TVD (22.47 vs. 27.51 mm/mm<sup>2</sup>, p < 0.009), PPV (90.76 vs. 95.91%, p < 0.001), PVD (20.44 vs. 26.41 mm/mm<sup>2</sup>, p < 0.001), venular RBC velocity (402.2 vs. 693.9 µm/s, p < 0.0004), and a decrease in MHI (0.33 vs. 0.04, p < 0.001. Thirteen of 20 patients showed a pharmacodynamic response, defined as an increase in PVD > 1.8 SD from shock baseline. Hemodynamics and vasoactive doses did not change during the 30-min study period. Our findings suggest a topical nitroglycerin challenge with handheld videomicroscopy can safely assess for localized recruitment of the microcirculatory blood flow in patients with circulatory shock and may be a useful test to identify nitroglycerin responsiveness.
Text Categorization via Ellipsoid Separation (2004)

The problem of document classification based on their semantic content (text categorization) arises when the documents from some set have to be ranked according to their relevance to some usually predefined set of topics (i.e. web search, classification of news articles based on their dealing with business topics). In this work we are going to present a new batch learning algorithm for text classification. Our method applies non-linear ellipsoid separation to the vector space representation of text documents representations. We use 'bag of words' vector representation of text documents, and maximal separation ratio method for pattern separation via ellipsoids [2] and kernel GSK algorithm [1] for feature extraction. Therefore we utilize maximization of the separation ratio and approximation of latent semantic feature extraction. We present some preliminary results which indicate high potential for the given approach.
Minimum Uncertainty Based Detection of Adversaries in Deep Neural Networks (2020)

Despite their unprecedented performance in various domains, utilization of Deep Neural Networks (DNNs) in safety-critical environments is severely limited in the presence of even small adversarial perturbations. The present work develops a randomized approach to detecting such perturbations based on minimum uncertainty metrics that rely on sampling at the hidden layers during the DNN inference stage. Inspired by Bayesian approaches to uncertainty estimation, the sampling probabilities are designed for effective detection of the adversarially corrupted inputs. Being modular, the novel detector of adversaries can be conveniently employed by any pre-trained DNN at no extra training overhead. Selecting which units to sample per hidden layer entails quantifying the amount of DNN output uncertainty, where the overall uncertainty is expressed in terms of its layer-wise components - what also promotes scalability. Sampling probabilities are then sought by minimizing uncertainty measures layer-by-layer, leading to a novel convex optimization problem that admits an exact solver with superlinear convergence rate. By simplifying the objective function, low-complexity approximate solvers are also developed. In addition to valuable insights, these approximations link the novel approach with state-of-the-art randomized adversarial detectors. The effectiveness of the novel detectors in the context of competing alternatives is highlighted through extensive tests for various types of adversarial attacks with variable levels of strength.
Methylmalonic and propionic acidemias: clinical management update (2016)

Management guidelines should identify necessary screening for patients with methylmalonic acidemia and propionic acidemia, and improve anticipatory management of progressive end-organ disease. Liver transplantation improves overall metabolic control, but injury to nonregenerative tissues may not be mitigated. Continued use of medical foods in these patients requires prospective studies to demonstrate evidence of benefit in a controlled manner.
Contact resistance measurements on p-type 6H-SiC (1993)

Specific contact resistance measurements are reported for Al-Ti ohmic contacts to epitaxial p-type 6H-SiC as a function of epitaxial doping. The circular transmission line method was used to measure the specific contact resistance including the sheet resistance of the epitaxial layer and the modified sheet resistance under the contact. Epitaxial layers with Al doping between 5.5×1015 and 2×1019 cm−3 yielded specific contact resistances between 2.9×10−2 and 1.5×10−5 Ω cm2. A good theoretical fit to the contact resistance data was obtained by assuming the metal-6H-SiC barrier height to equal 0.37 eV.
Adaptive filter based low complexity digital intensive harmonic rejection for SDR receiver (2013)

Harmonic rejection mixing is indispensable in software defined radio receivers employing switched mixers. Current analog multi-path mixing solution suffers from phase and gain mismatches along the paths and as a consequence cannot provide sufficient harmonic rejection. In this paper, we present a low complexity flexible digital intensive harmonic rejection architecture and show how it can be used to enhance the rejection of any single harmonic interference by adaptively combining the different mixing paths. Simulation results show that the proposed method can reject any single interferer adaptively by over 80 dB, which is sufficient for practical applications.
The design and synthesis of inhibitors of dethiobiotin synthetase as potential herbicides (1999)

Dethiobiotin synthetase (DTBS; E.C. 6.6.6.6), thepenultimate enzyme in the biosynthesis of the essential vitaminbiotin, is a new potential target for novel herbicides. Inhibitorswere designed based on mechanistic and structural information. Thein-vitro activities of these potential inhibitors versus thebacterial enzyme are reported here. Mimics of7,8-diaminopelargonic acid (DAPA) or the DAPAcarbamate reaction intermediate were substrates or partial substratesfor the enzyme. Synergistic binding with ATP was noted with compoundswhich contained an amino functionality. NMR studies and X-raystructures confirmed that the inhibitors could be phosphorylated bythe enzyme. Several series of potential inhibitors were designed totake advantage of this partial substrate activity by generatingpotentially more tightly bound phosphorylated inhibitors in situ. Structure–activity relationships for these series based onboth substrate and inhibitory activity are described herein. AnX-ray structure for one of these inhibitors is also discussed.Although considerable potential for inhibitors of this type wasdemonstrated, none of the compounds reported showed sufficientherbicidal activity to be a commercial proposition. © 1999 Society of Chemical Industry
Rapid Symptom Resolution with Delayed Release Mesalamine in Mildly and Moderately Active UC (2007)

Purpose: To evaluate time to clinical remission in patients with mild and moderate active UC receiving 2.4 g/d of Asacol (mesalamine) delayed-release tablets. Methods: Data from 2 multi-center, randomized, double-blind, active-controlled, 6-wk studies of similar design (ASCEND I&II) were combined and analyzed. The studies included patients with mild (PGA = 1) and moderate (PGA = 2) active UC. This analysis includes data from the 2.4 g/d active control arms of these studies. Clinical remission was defined as resolution (score = 0) of both rectal bleeding (RB) and stool frequency (SF). Resolution of RB was defined as the absence of visible blood in stools and resolution of SF was defined as a patient's return to his/her normal number of stools/day. To be included in analysis patients had to have symptoms at baseline. Time to clinical remission was defined as the first day of 3 consecutive days of complete symptom resolution based on symptoms recorded by patients daily through an integrated voice response system (IVRS). Results: 687 patients were randomized in the 2 studies, of which 349 received 2.4 g/d. Based on IVRS data, the median time to clinical remission in patients with mild and moderate active UC was 26 days (95% CI 24,33). Time to clinical remission by disease severity is shown below:[figure1]In addition, results of the time to complete resolution analysis by individual symptoms and disease severity are shown below:FigureTableAsacol 2.4 g/d was well-tolerated, with adverse events consistent with those described in the current prescribing information. In pivotal clinical studies of active UC, the most frequent adverse events reported for Asacol were headache, abdominal pain, and eructation. Conclusion: In active UC, rapid symptom relief is a key treatment goal. Asacol 2.4 g/d provided rapid symptom relief in patients with mild and moderate active UC.
Signal and image reconstruction from partial Fourier phase (2002)

A novel approach to signal representation by partial Fourier phase is given. It is shown that an amplitude-dependent bit allocation method preserves most of the signal's structures. Improved reconstruction algorithms are illustrated using imprecise phase and some of the signal's statistical characteristics. A recent complementary study provides a classification algorithm based on partial phase information, which is invariant to 2D similarity deformations (scale, rotation and shift).
Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV‐1 infectivity (1995)

In this study 96 15-mer peptides encompassing the entire sequence of HIV-1 gp120 were synthesized and used to immunize BALB/c mice (i) alone or (ii) in conjunction with the T helper cell determinant FISEAIIHVLHSR (FIS) from sperm whale myoglobin, which is well recognized by major histocompatibility complex (MHC) class II molecules of BALB/c. Of these peptides 39 were immunogenic per se and 57 were not. Out of the 57 non-immunogenic peptides 53 could be rendered immunogenic with the second immunization protocol. With the exception of 4 cases, the anti-peptide antibody titers induced in (ii) were equal (14 cases) or higher (78 cases) than those induced in (i). From the 96 anti-peptide antibodies tested, 12 were able to recognize recombinant gp120 with good antibody titers, a result in agreement with previously identified B cell epitopes from gp120 by anti-peptide antibodies induced with longer peptides conjugated to a carrier protein. Moreover, 4 of the 12 anti-peptide antisera that recognized gp120 were able to neutralize HIV-1 infectivity in vitro, showing that the strategy of co-immunization with FIS may afford functional antibodies.
To Be Announced (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Vlasov, "To Be Announced," in Photonic Metamaterials: From Random to Periodic, Technical Dgest (CD) (Optica Publishing Group, 2006), paper TuB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article