gebhart/patrepeval huggingface dataset:
Design a Hash-Based Control Mechanism in vSwitch for Software-Defined Networking Environment (2015)

Unlike a traditional network architecture, a software-defined networking architecture is divided into the control plane and the data plane. Network administrators use the centralized control plane to manage network authority and determine where network traffic is to be sent in the data plane. However, a centralized control structure causes a bottleneck with an overloading flow or under a DDoS attack. Under such conditions, the probability of network misconfiguration may increase rapidly and network performance may decline rapidly. This work paper proposes a hash-based mechanism that operates in the control plane to increase the reliability and scalability of the network. The hash function is utilized to assign incoming packets to queues in the control plane. The controller schedules the queues using a round-robin method to reduce the probability of failure in response to malicious attacks and to reduce transmission delay when network congestion occurs. The experimental results reveal that the proposed mechanism effectively distributes the workload and increases the reliability of the network under high-density data transmission.
New-concept i-line stepper for mask fabrication (2000)

We have developed a new reticle exposure system, which can fabricate 150nm generation masks by means of a stitching exposure technique. We call this exposure system the Photomask Repeater, or high accuracy repeater (HR). HR is a modified i-line stepper for mask manufacturing with a field size of 22 by 22 mm in a single exposure. However, the device size on a 4x mask is larger than 22 by 22 mm. Furthermore the improvement in mask CD uniformity is required. For this purpose the exposure field size was extended with the use of 'seamless stitching technology'. This is the key to obtaining a feasible exposure system with the use of this method. Results have been achieved with this system showing CD variation of less than +/- 5 nm across a 1D seam band by means of a 'gradation filter'. Moreover, overall Cd uniformity is less than 13nm, while image placement accuracy is less than 24nm. HR is an attractive system for SoC mask manufacturing, and is also effective in reducing TAT.
Comparison of radiographer interobserver image registration variability using cone beam CT and MR for cervix radiotherapy (2020)

This is the first publication quantifying interobserver registration of multimodality image registration strategies for cervix radical radiotherapy patients.
Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1 (2018)

Gene-based therapies represent a promising therapeutic paradigm for the treatment of HIV-1, as they have the potential to maintain sustained viral inhibition with reduced treatment interventions. Such an option may represent a long-term treatment alternative to highly active antiretroviral therapy. <b>Methods:</b> We previously described a therapeutic approach, referred to as transcriptional gene silencing (TGS), whereby small noncoding RNAs directly inhibit the transcriptional activity of HIV-1 by targeting sites within the viral promoter, specifically the 5' long terminal repeat (LTR). TGS differs from traditional RNA interference (RNAi) in that it is characterized by concomitant silent-state epigenetic marks on histones and DNA. To deliver TGS-inducing RNAs, we developed functional RNA conjugates based on the previously reported dual function of the gp120 (A-1) aptamer conjugated to 27-mer Dicer-substrate anti-HIV-1 siRNA (dsiRNA), LTR-362. <b>Results:</b> We demonstrate here that high levels of processed guide RNAs localize to the nucleus in infected T lymphoblastoid CEM cell line and primary human CD4+ T-cells. Treatment of the aptamer-siRNA conjugates induced TGS with an ~10-fold suppression of viral p24 levels as measured at day 12 post infection. To explore the silencing efficacy of aptamer-siRNA conjugates <i>in vivo</i>, HIV-1-infected humanized NOD/SCID/IL2 rγ<sup>null</sup> mice (hu-NSG) were treated with the aptamer-siRNA conjugates. Systemic delivery of the A-1-stick-LTR-362 27-mer siRNA conjugates suppressed HIV-1 infection and protected CD4+ T cell levels in viremia hu-NSG mice. <b>Principle conclusions:</b> Collectively these data suggest that the gp120 aptamer-dsiRNA conjugate design is suitable for systemic delivery of small RNAs that can be used to suppress HIV-1.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage (2019)

Meprin β is a membrane-bound metalloprotease involved in extracellular matrix assembly and inflammatory processes in health and disease. A disintegrin and metalloproteinase (ADAM)10 and ADAM17 are physiologic relevant sheddases of inactive promeprin β, which influences its substrate repertoire and subsequent biologic functions. Proteomic analysis also revealed several ADAMs as putative meprin β substrates. Here, we demonstrate specific N-terminal processing of ADAM9, 10, and 17 by meprin β and identify cleavage sites within their prodomains. Because ADAM prodomains can act as specific inhibitors, we postulate a role for meprin β in the regulation of ADAM activities. Indeed, prodomain cleavage by meprin β caused increased ADAM protease activities, as observed by peptide-based cleavage assays and demonstrated by increased ectodomain shedding activity. Direct interaction of meprin β and ADAM proteases could be shown by immunofluorescence microscopy and immunoprecipitation experiments. As demonstrated by a bacterial activator of meprin β and additional measurement of TNF-α shedding on bone marrow-derived macrophages, meprin β/ADAM protease interactions likely influence inflammatory conditions. Thus, we identified a novel proteolytic pathway of meprin β with ADAM proteases to control protease activities at the cell surface as part of the protease web.-Wichert, R., Scharfenberg, F., Colmorgen, C., Koudelka, T., Schwarz, J., Wetzel, S., Potempa, B., Potempa, J., Bartsch, J. W., Sagi, I., Tholey, A., Saftig, P., Rose-John, S., Becker-Pauly, C. Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Abstract 1086: Immune checkpoint inhibitorsCD300AandLAIR1are associated with poor prognosis in clear cell renal cell carcinoma (2019)

Immune checkpoint inhibitors targeting the programmed cell death-1 receptor (PD-1) have been shown to improve the survival of patients with clear cell renal cell carcinoma (CCRCC). However, a benefit for CCCRC patients was observed with the FDA-approved PD-1 inhibitor Nivolumab irrespective of PD-1 ligand (PD-L1) expression status indicating there are potentially additional CCRCC checkpoint molecules worth exploring for targeted therapy. We therefore analyzed RNAseq data (n=534, CCRCCs; n=72, normal kidney specimens) from the TCGA project, and found that PD-L1 was not upregulated in CCRCC when compared to normal tissue whereas other checkpoint members i.e. CD300A and LAIR1 were among the most significantly upregulated genes in CCRCCs. In terms of overall survival, high expression of PD-L1 was associated with better outcome in CCRCCs while high expression of CD300A and LAIR1 were significantly associated with worse outcomes. We confirmed these findings in two independent cohorts of CCRCC patients. Furthermore, we performed cell type enrichment analysis, which showed that CD300A and LAIR1 are most likely expressed by tumor-associated macrophages in the CCRCC tumor microenvironment. Our results suggest that PD1/PDL1 might be suboptimal targets in CCRCC and that there are additional unexplored immune checkpoint molecules that warrant our attention.Note: This abstract was not presented at the meeting.Citation Format: Jonas Sjolund, David Lindgren, Helén Nilsson, Martin E. Johansson, Hakan Axelson, Kristian Pietras. Immune checkpoint inhibitors CD300A and LAIR1 are associated with poor prognosis in clear cell renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1086.
Robust algorithms for direction finding and adaptive beamforming: performance and optimization (2004)

This paper presents a performance evaluation of robust algorithms for direction finding and adaptive beamforming used in the design of smart antenna systems. A simulation tool with a graphical user interface which implements these algorithms is developed. Results of numerical simulation are used to design smart antennas systems with optimal performance.
hsa-MiR-19a-3p and hsa-MiR-19b-3p Are Associated with Spinal Cord Injury-Induced Neuropathic Pain: Findings from a Genome-Wide MicroRNA Expression Profiling Screen (2021)

Neuropathic pain in spinal cord injury (SCI) is associated with inflammation in both the peripheral and central nervous system (CNS), which may contribute to the initiation and maintenance of persistent pain. An understanding of factors contributing to neuroinflammation may lead to new therapeutic targets for neuropathic pain. Moreover, novel circulating biomarkers of neuropathic pain may facilitate earlier and more effective treatment. MicroRNAs (miRNAs) are short, non-coding single-stranded RNA that have emerged as important biomarkers and molecular mediators in physiological and pathological conditions. Using a genome-wide miRNA screening approach, we studied differential miRNA expression in plasma from 68 healthy, community-dwelling adults with and without SCI enrolled in ongoing clinical studies. We detected 2367 distinct miRNAs. Of these, 383 miRNAs were differentially expressed in acute SCI or chronic SCI versus no SCI and 71 were differentially expressed in chronic neuropathic pain versus no neuropathic pain. We selected homo sapiens (hsa)-miR-19a-3p and hsa-miR-19b-3p for additional analysis based on <i>p</i>-value, fold change, and their known role as regulators of neuropathic pain and neuroinflammation. Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. In confirmatory studies, both hsa-miR-19a-3p and hsa-miR-19b-3p have moderate to strong discriminative ability to distinguish between those with and without pain. After adjusting for opioid use, hsa-miR-19b-3p levels were positively associated with pain interference with mood. Because hsa-miR-19 levels have been shown to change in response to exercise, folic acid, and resveratrol, these studies suggest that miRNAs are potential targets of therapeutic interventions.
Design of Ultra-Small Polarization Splitter Based on a Resonant Coupling between Silicon Wire and Slot Waveguides (2009)

We propose an ultra-small polarization splitter based on a resonant tunneling phenomenon. Numerical simulations show that a 16-μm-long polarization splitter with extinction ratio better than −20 dB on the entire C-band is achievable.
WORLDWIDE WEATHER RADAR IMAGERY MAY ALLOW SUBSTANTIAL INCREASE IN METEORITE FALL RECOVERY. (2014)

Weather radar imagery is a valuable new technique for the rapid recovery of falls, to include falls which would not otherwise be recovered (e.g. Battle Mountain). Weather radar imagery reveals about one new fall per year (18 falls since 1998), using weather radars in the United States alone. However, an additional ~75 other nations operate weather radar networks according to the UN World Meteorological Organization (WMO). If the imagery of those radars were analyzed, the current rate of falls could be improved considerably, to as much as ~3.6 times the current recovery rate based on comparison of total radar areal coverage. Recently, the addition of weather radar imagery, seismometry and internet-based aggregation of eyewitness reports has improved the speed and accuracy of fresh fall recovery [e.g. 1,2]. This was demonstrated recently with the radar-enabled recovery of the Sutter's Mill fall [3]. Arguably, the meteorites recovered via these methods are of special scientific value as they are relatively unweathered, fresh falls. To illustrate this, a recent SAO/NASA ADS search using the keyword meteorite shows that all 50 of the top search results included at least one named recovered from a fall. This is true even though only ~1260 named falls are recorded among the >49,000 individual falls recorded in the Meteoritical Society online database. The US NEXRAD system used thus far to locate falls covers most of the United States' surface area. Using a WMO map of the world's weather radars, we estimate that the total coverage of the other ~75 national weather radar networks equals about 3.6x NEXRAD's coverage area. There are two findings to draw from this calculation: 1) For the past 16 years during which 18 falls are seen in US radar data, there should be an additional ~65 falls recorded in worldwide radar imagery. Also: 2) if all of the world's radar data could be analyzed, the rate of recovery of fresh falls can increase by as much as ~3.6x the current rate. The authors' experience to date indicates that the most effective course of action would be to have local research groups (outside of the US) form research consortia and develop a working relationship with their nation's weather bureau for access to data. These research consortia could utilize the same, proven methods used for US NEXRAD imagery, internet eyewitness report aggregation, seismometry analysis, etc. to locate falls. The consortia could then recover and analyze falls and enrich their own research efforts. It would be beneficial to conduct a global program to coordinate the development of methods and data tools, as well as to coordinate sample sharing and research. Perhaps an institution such as the Meteoritical Society could lead such an effort.
A new ecological primary flight display concept (2008)

In the current generation electronic primary flight displays, all variables are scaled and displayed without regard to the inherent relationship between airplane flight path and speed related variables, and without regard how the controls of thrust and elevator should be used. This leaves the pilot to solely rely on his experience and skills to realize the desired state of aircraft speed and flight path. The goal of the ecological energy management primary flight display, is to make constraints and complex relationships between various flight dynamics display variables visible and directly actionable to the pilot. In this context, the energy domain is identified as a means to normalize and visualize the relationships between speed and altitude targets, acceleration, vertical speed and flight path angle and to bring out control guidance cues for the efficient use of elevator and throttle control. The feasibility of such an ecological primary flight display is addressed through an analysis of the scaling dependencies. Following an overview of the design issues and required design decisions, the practicality is addressed through an example implementation and a comparison with existing display formats and design recommendations. Finally, recommendations for research are provided to assess the suitability and effectiveness of such a display in improving pilot control performance and workload.
Fast in-device overlay metrology on multi-tier 3DNAND devices without DECAP and it’s applications in process characterization and control (2021)

Multilayer stack height in 3DNAND has reached the limit of the aspect ratio that etch technologies can cost-effectively achieve. The solution to achieve further bit density scaling is to build the stack in two tiers, each etched separately. While lowering the requirements on etch aspect ratio, stacking two tiers introduces a critical overlay at the interface between the stacks. Due to the height of each stack, stress- or etch-induced tilt in the channel holes is translated into overlay. Characterizing and controlling the resulting complex overlay fingerprints requires dense and frequent overlay metrology. The familiar electron beam metrology after etch-back (DECAP) is destructive and therefore too slow and expensive for frequent measurements. This paper will introduce a fast, accurate &amp; robust data-driven method for In Device Overlay Metrology (IDM) on etched 3DNAND devices by making use of specially designed recipe setup targets. Also, potential applications for process control improvement will be demonstrated.
Psychological and Physical Health of Nonoffending Parents After Disclosure of Sexual Abuse of Their Child (2016)

Disclosure of child sexual abuse can be traumatic for nonoffending parents. Research has shown its impact on mothers' mental health, which includes heightened psychological distress, depression, and post-traumatic stress disorder. Very little is known, however, about its impact on their physical health or on fathers' health. The self-perceived mental and physical health of nonoffending parents after child sexual abuse disclosure was compared to determine gender-related differences in this regard. Interviews were conducted with 109 mothers and 43 fathers of 6- to 13-year-old sexually abused children. Bivariate analyses revealed that a fair proportion of parents reported psychological and physical problems after disclosure. However, proportionally more mothers than fathers reported psychological distress, depression, and use of professional services. Fathers were more likely to resort to health services instead of social services and to use medication for depression. Study findings provide leads for health and social service providers for the development of intervention protocols and referral procedures sensitive to gender issues, and they shed new light on specific needs of nonoffending parents.
Contour-based recognition (2012)

Contour is an important cue for object recognition. In this paper, built upon the concept of torque in image space, we propose a new contour-related feature to detect and describe local contour information in images. There are two components for our proposed feature: One is a contour patch detector for detecting image patches with interesting information of object contour, which we call the Maximal/Minimal Torque Patch (MTP) detector. The other is a contour patch descriptor for characterizing a contour patch by sampling the torque values, which we call the Multi-scale Torque (MST) descriptor. Experiments for object recognition on the Caltech-101 dataset showed that the proposed contour feature outperforms other contour-related features and is on a par with many other types of features. When combing our descriptor with the complementary SIFT descriptor, impressive recognition results are observed.
Supplementary Tables 1 and 2 and Supplementary Figures 1 through 7 from Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia (2023)

&lt;p&gt;Table S1. Summary of samples used for this study. Table S2. Antibodies used in the study. Figure S1. Mass spectra of all peptides referenced in figures 2 and 3. Figure S2. ETD Mass spectrum of RPPItQSSL containing an asymmetrically dimethylated Arg residue. Figure S3. ICS flow cytometry plots for HD5. Figure S4. Gating strategy for phenotyping shown in Fig 2E. Figure S5. Healthy donor immunity to O-GlcNAc peptides measured using IFNgamma ELISpot. Figure S6. ICS flow cytometry plots for HD5. Figure S7. Positional analysis of O-GlcNAc peptides.&lt;/p&gt;
Studies of a two-section backward wave oscillator for efficient high power microwave generation (1993)

Summary form only given. The effects of a nonuniform amplitude slow-wave structure are being studied using the University of New Mexico's high-power relativistic backward wave oscillator (BWO) driven by a SINUS-6 repetitively pulsed electron beam accelerator. The BWO produces a 12-ns microwave pulse with a peak power of 600 MW at 9.6 GHz. The ripples within the slow-wave structure have a constant period of 15 cm, but their amplitudes were arranged in two sections to increase the efficient microwave radiation. In the first half of the slow-wave structure the ripples have a small amplitude while in the second half the ripples have a much larger amplitude. Different configurations of the two-stage slow-wave structure were used and compared with the total output of microwave power. The changes to the slow-wave structure were compared with MAGIC computer simulations, which suggest that the first section of shallow ripples prebunches the electron beam and results in greater efficiency of microwave generation in the second section.
NO increases permeability of cultured human cervical epithelia by cGMP-mediated increase in G-actin (2000)

Human cervical epithelial cells express mRNA for the nitric oxide (NO) synthase (NOS) isoforms ecNOS, bNOS, and iNOS and release NO into the extracellular medium. N(G)-nitro-L-arginine methyl ester (L-NAME), an NOS inhibitor, and Hb, an NO scavenger, decreased paracellular permeability; in contrast, the NO donors sodium nitroprusside (SNP) and N-(ethoxycarbonyl)-3-(4-morpholinyl)sydnonimine increased paracellular permeability across cultured human cervical epithelia on filters, suggesting that NO increases cervical paracellular permeability. The objective of the study was to understand the mechanisms of NO action on cervical paracellular permeability. 8-Bromo-cGMP (8-BrcGMP) also increased permeability, and the effect was blocked by KT-5823 (a blocker of cGMP-dependent protein kinase), but not by LY-83583 (a blocker of guanylate cyclase). In contrast, LY-83583 and KT-5823 blocked the SNP-induced increase in permeability. Treatment with SNP increased cellular cGMP, and the effect was blocked by Hb and LY-83583, but not by KT-5823. Neither SNP nor 8-BrcGMP had modulated cervical cation selectivity. In contrast, both agents increased fluorescence from fura 2-loaded cells in the Ca(2+)-insensitive wavelengths, indicating that SNP and 8-BrcGMP stimulate a decrease in cell size and in the resistance of the lateral intercellular space. Neither SNP nor 8-BrcGMP had an effect on total cellular actin, but both agents increased the fraction of G-actin. Hb blocked the SNP-induced increase in G-actin, and KT-5823 blocked the 8-BrcGMP-induced increase in G-actin. On the basis of these results, it is suggested that NO acts on guanylate cyclase and stimulates an increase in cGMP; cGMP, acting via cGMP-dependent protein kinase, shifts actin steady-state toward G-actin; this fragments the cytoskeleton and renders cells more sensitive to decreases in cell size and resistance of the lateral intercellular space and, hence, to increases in permeability. These results may be important for understanding NO regulation of transcervical paracellular permeability and secretion of cervical mucus in the woman.
Fabrication of Porous Aluminum / Thin-Walled Pipe Composite Materials by Applying Friction Welding (2013)

In this study, porous aluminum core filled in hollow steel pipe composite materials (porous Al core pipe) was fabricated by applying friction welding. Al plates and blowing agent powder were put into the hollow steel pipe, and the rotating tool was pressed into the Al plates. Friction heat was generated and precursor of porous Al was fabricated by mixing Al plates and blowing agent powder by means of plastic flow. Porous core pipe with metal bonding was successfully fabricated by heating the precursor. The compression properties and deformation behavior of porous Al core pipe was obtained by the compression test. As a result, energy absorption per unit of volume of porous Al core pipe increased 1.5 times compare with the hollow pipe. But, the energy absorption per unit mass was slightly decreased.
Reduction of the Power Consumption in a WDM/SDM Network by using Cladding Pump Scheme MC-EDFA with Impairment Aware Least Wavelength Bandwidth Routing (2018)

We show 39 % reduction of amplification power consumption with cladding pump MC-EDFA using 16-core spectral superchannels over SDM NSFNET16 topology. Impairment aware least wavelength bandwidth routing algorithm further reduces the power consumption by 45%.