gebhart/patrepeval huggingface dataset:
vNFS (2017)

Modern systems use networks extensively, accessing both services and storage across local and remote networks. Latency is a key performance challenge, and packing multiple small operations into fewer large ones is an effective way to amortize that cost, especially after years of significant improvement in bandwidth but not latency. To this end, the NFSv4 protocol supports a compounding feature to combine multiple operations. Yet compounding has been underused since its conception because the synchronous POSIX file-system API issues only one (small) request at a time. We propose vNFS , an NFSv4.1-compliant client that exposes a vectorized high-level API and leverages NFS compound procedures to maximize performance. We designed and implemented vNFS as a user-space RPC library that supports an assortment of bulk operations on multiple files and directories. We found it easy to modify several UNIX utilities, an HTTP/2 server, and Filebench to use vNFS. We evaluated vNFS under a wide range of workloads and network latency conditions, showing that vNFS improves performance even for low-latency networks. On high-latency networks, vNFS can improve performance by as much as two orders of magnitude.
Oxazolidinone: Search for Highly Potent Antibacterial. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A new surgical technique of uterine auto-transplantation in cynomolgus monkey: preliminary report about two cases (2011)

This is the preliminary report of uterine auto-transplantation in cynomolgus monkeys. This study demonstrates the feasibility of uterine auto-transplantation by using new surgical technique in cynomolgus monkeys. Accumulation of basic experimental data in non-human primates is required prior to performing the procedure in humans.
Multi-dimensional effects on the propagation of strain solitons in solids (2007)

Numerical simulations on the generation and the propagation of phonon solitons in crystalline solids have so far been made extensively with KdV equation in one dimension. We extend these analyses to two and three dimensions by treating the effect of the transverse directions as a small perturbation. Explicitly, we first derive the two-dimensional KP equation and also its three-dimensional version for the strain field. Then, time evolutions of the initial strain distributed with a Gaussian profile normal to the main propagation direction are studied.
A spectral line curve fitting based algorithm for inter-harmonics measurement (2018)

The inter-harmonics produced by those power electronic devices leads to a more frequent occurrence of sub-synchronous oscillations (SSO). Many existing measuring methods are not suitable for the inter-harmonics measurement in the environment where plenty of power electronic devices exist. In this paper, a fast and precise measuring algorithm based on FFT and curve fitting is proposed to estimate the sub/super-synchronous harmonics. The windowing technique is used to reduce the spectral leakage firstly. Secondly, zero-padding is adopted to mitigate the picket-fence effect. Lastly, spectrum line curve fitting is applied to perform the inter-harmonic analysis. The simulation and experiment results indicate that the proposed algorithm is able to perform an accurate, real-time and anti-noise inter-harmonics estimation. Experiment results verify the accuracy and effectiveness of the proposed algorithm.
Digital Signal Processing for High-Speed Fiber-Wireless Convergence [Invited] (2018)

We review recent advances in the field of fiber-wireless convergence to better support cloud radio access networks via high-speed low-latency mobile fronthaul between remote radio units and baseband units. We also present how digital signal processing (DSP) may be used to support both common public radio interfaces (CPRI) in a point-to-point architecture and Ethernet-based CPRI in a point-to-multipoint architecture to achieve high bandwidth efficiency and low processing latency. The use of DSP-enabled next-generation passive optical networks (PON), such as 50 Gb/s PON, to support mobile fronthaul in a resource-efficient manner will also be discussed.
A Model for Designing Adaptive Laboratory Evolution Experiments (2017)

The occurrence of mutations is a cornerstone of the evolutionary theory of adaptation, capitalizing on the rare chance that a mutation confers a fitness benefit. Natural selection is increasingly being leveraged in laboratory settings for industrial and basic science applications. Despite increasing deployment, there are no standardized procedures available for designing and performing adaptive laboratory evolution (ALE) experiments. Thus, there is a need to optimize the experimental design, specifically for determining when to consider an experiment complete and for balancing outcomes with available resources (i.e., laboratory supplies, personnel, and time). To design and to better understand ALE experiments, a simulator, ALEsim, was developed, validated, and applied to the optimization of ALE experiments. The effects of various passage sizes were experimentally determined and subsequently evaluated with ALEsim, to explain differences in experimental outcomes. Furthermore, a beneficial mutation rate of 10<sup>-6.9</sup> to 10<sup>-8.4</sup> mutations per cell division was derived. A retrospective analysis of ALE experiments revealed that passage sizes typically employed in serial passage batch culture ALE experiments led to inefficient production and fixation of beneficial mutations. ALEsim and the results described here will aid in the design of ALE experiments to fit the exact needs of a project while taking into account the resources required and will lower the barriers to entry for this experimental technique.<b>IMPORTANCE</b> ALE is a widely used scientific technique to increase scientific understanding, as well as to create industrially relevant organisms. The manner in which ALE experiments are conducted is highly manual and uniform, with little optimization for efficiency. Such inefficiencies result in suboptimal experiments that can take multiple months to complete. With the availability of automation and computer simulations, we can now perform these experiments in an optimized fashion and can design experiments to generate greater fitness in an accelerated time frame, thereby pushing the limits of what adaptive laboratory evolution can achieve.
Self-aligned placement of biologically synthesized Coulomb islands within nanogap electrodes for single electron transistor (2009)

Biological synthesis and self-aligned placement of a Coulomb island was demonstrated for single electron transistor (SET) fabrication using a cage-shaped protein, apoferritin. Homogenous ϕ7 nm Co3O4 and In oxide nanoparticles (NPs) were synthesized utilizing the apoferritin cavity as a spatially restricted chemical reaction chamber. Apoferritin accommodating a NP (Co3O4, In oxide) showed specific affinity to a Ti surface and self-aligned itself between a pair of Au/Ti nanogap electrodes. After the protein cage was eliminated, two tunnel junctions between the NP and each electrode had the same gap, thereby forming an ideal SET structure. The produced SET exhibited a Coulomb-staircase/oscillation at 4.2 K.
Novel immunotherapies for hematologic malignancies (2014)

The immune system is designed to discriminate between self and tumor tissue. Through genetic recombination, there is fundamentally no limit to the number of tumor antigens that immune cells can recognize. Yet, tumors use a variety of immunosuppressive mechanisms to evade immunity. Insight into how the immune system interacts with tumors is expanding rapidly and has accelerated the translation of immunotherapies into medical breakthroughs. Herein, we appraise novel strategies that exploit the patient's immune system to kill cancer. We review various forms of immune-based therapies, which have shown significant promise in patients with hematologic malignancies, including (i) conventional monoclonal therapies like rituximab; (ii) engineered monoclonal antibodies called bispecific T-cell engagers; (iii) monoclonal antibodies and pharmaceutical drugs that block inhibitory T-cell pathways (i.e. PD-1, CTLA-4, and IDO); and (iv) adoptive cell transfer therapy with T cells engineered to express chimeric antigen receptors or T-cell receptors. We also assess the idea of using these therapies in combination and conclude by suggesting multi-prong approaches to improve treatment outcomes and curative responses in patients.
THE ENHANCER OF ZESTE HOMOLOG 2 GENE CONTRIBUTES TO CELL PROLIFERATION AND APOPTOSIS RESISTANCE IN RENAL CELL CARCINOMA CELLS (2008)

You have accessJournal of Urology1 Apr 2008THE ENHANCER OF ZESTE HOMOLOG 2 GENE CONTRIBUTES TO CELL PROLIFERATION AND APOPTOSIS RESISTANCE IN RENAL CELL CARCINOMA CELLS Nina Wagener, Daniela Holland, Irena Crnkovic-Mertens, Karin Hoppe-Seyler, Hanswalter Zentgraf, Maria Pritsch, Stephan Buse, Jesco Pfitzenmaier, Axel Haferkamp, Markus Hohenfellner, and Felix Hoppe-Seyler Nina WagenerNina Wagener More articles by this author , Daniela HollandDaniela Holland More articles by this author , Irena Crnkovic-MertensIrena Crnkovic-Mertens More articles by this author , Karin Hoppe-SeylerKarin Hoppe-Seyler More articles by this author , Hanswalter ZentgrafHanswalter Zentgraf More articles by this author , Maria PritschMaria Pritsch More articles by this author , Stephan BuseStephan Buse More articles by this author , Jesco PfitzenmaierJesco Pfitzenmaier More articles by this author , Axel HaferkampAxel Haferkamp More articles by this author , Markus HohenfellnerMarkus Hohenfellner More articles by this author , and Felix Hoppe-SeylerFelix Hoppe-Seyler More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60257-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "THE ENHANCER OF ZESTE HOMOLOG 2 GENE CONTRIBUTES TO CELL PROLIFERATION AND APOPTOSIS RESISTANCE IN RENAL CELL CARCINOMA CELLS." The Journal of Urology, 179(4S), pp. 88–89 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 88-89 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Nina Wagener More articles by this author Daniela Holland More articles by this author Irena Crnkovic-Mertens More articles by this author Karin Hoppe-Seyler More articles by this author Hanswalter Zentgraf More articles by this author Maria Pritsch More articles by this author Stephan Buse More articles by this author Jesco Pfitzenmaier More articles by this author Axel Haferkamp More articles by this author Markus Hohenfellner More articles by this author Felix Hoppe-Seyler More articles by this author Expand All Advertisement PDF downloadLoading ...
Phase and Gain Imbalance Compensation in Low-IF Receivers (2015)

In this paper, we present a modified image rejection method that uses imbalance compensation techniques for phase and gain in low-intermediate frequency (IF) software-defined radio (SDR) receivers. In low-IF receivers, the image frequency signal interferes with the desired signal owing to the phase and gain imbalances caused by analog devices. Thus, it is difficult to achieve the required image rejection ratio (IRR) of over 60dB without compensation. To solve this problem, we present modified blind compensation techniques based on digital signal processing using a feedback control loop with a practical computation process. The modified method can reduce the complexity when a hardware logic circuit is used, like an FPGA. The simulation and experimental results verify that the modified method achieves an IRR greater than 50-60dB for both the carrier and the modulated waves.
Patterns of Oxygenation and Cardiovascular Adjustment to Acute, Transient Normovolemic Anemia (1968)

Michalski, A. H.; Lowenstein, E.; Austen, W. G.; Buckley, M. J.; Laver, M. B. Author Information
Development strategy and lessons learned for a 10-valent pneumococcal conjugate vaccine ( PNEUMOSIL® ) (2021)

Pneumococcal conjugate vaccines (PCVs) have proven to be the best way to prevent severe childhood pneumococcal disease but until recently have been difficult for many countries to afford sustainably. In 2008, the Serum Institute of India, Pvt. Ltd. and PATH entered into a collaboration, funded in part by the Bill & Melinda Gates Foundation, to respond to this problem by developing a PCV designed to be affordable, accessible, and protective against the pneumococcal serotypes causing the most morbidity and mortality in low- and middle-income countries. The resulting 10-valent PCV (<i>PNEUMOSIL®</i>) received World Health Organization prequalification in December 2019 - making it just the third PCV to be certified as an option for Gavi, the Vaccine Alliance-eligible countries - and is being made available at a Gavi price of US$2/dose. The task of developing a state-of-the-art, yet lower-priced, PCV required public-private collaboration across geographies and yielded a variety of successes and learnings useful to the vaccine development field. Key among the learnings were factors related to manufacturing strategy and optimization, serotype selection, flexibility, early risk detection and mitigation, partner trust and continuity across similar-class products, complementary business philosophies, and early clarity of purpose.
Precise Compositional Control and Systematic Preparation of Multimonomeric Statistical Copolymers (2013)

A comprehensive approach to target exact molecular weights and chemical compositions for multimonomeric statistical copolymers using a new controlled statistics method with reversible addition-fragmentation chain transfer free-radical (RAFT) polymerization is presented. The system chosen to illustrate this procedure is an acrylic quarterpolymer consisting of methyl acrylate, 2-carboxyethyl acrylate, 2-hydroxypropyl acrylate, and 2-propylacetyl acrylate, modeling a well-known macromolecule utilized to deliver poorly water-soluble drugs (hydroxypropyl methylcellulose acetate succinate, HPMCAS). The relative reactivities at 70 °C between monomer pairs were measured and employed to predict the feed ratio necessary for synthesizing well-defined compositions based on the Walling-Briggs model. Application of Skeist's equations addressed compositional drift and anticipated the general monomer incorporation distribution as a function of conversion, which was verified experimentally. This new and simple paradigm combining both predictive models provides complementary synthetic and predictive tools for designing macromolecular chemical architectures with hierarchical control over spatially dependent structure-property relationships for complex applications such as oral drug delivery.
Nanoparticle-induced light scattering for improved performance of quantum-well solar cells (2008)

We report on the improved performance of InP∕InGaAsP quantum-well waveguide solar cells via light scattering from deposited dielectric or metal nanoparticles. The integration of metal or dielectric nanoparticles above the quantum-well solar cell device is shown to couple normally incident light into lateral optical propagation paths, with optical confinement provided by the refractive index contrast between the quantum-well layers and surrounding material. With minimal optimization, short-circuit current density increases of 12.9% and 7.3% and power conversion efficiency increases of 17% and 1% are observed for silica and Au nanoparticles, respectively.
Cone‐shaped surface GaN‐based light‐emitting diodes (2005)

Our technical approach for high light extraction is forming well-defined cone-like structures without any deterioration of the light-emitting diode (LED) surface. The laser lift off (LLO) technique combined with photo electrochemical etching (PEC) allows for the development of a high light extraction structure. The extraction efficiency enhancement produced a four-fold increase for an unencapuslated chip compared with a conventionally processed LED. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Design and performance of an ultra-flexible two-photon microscope for in vivo research (2015)

We present a cost-effective in vivo two-photon microscope with a highly flexible frontend for in vivo research. Our design ensures fast and reproducible access to the area of interest, including rotation of imaging plane, and maximizes space for auxiliary experimental equipment in the vicinity of the animal. Mechanical flexibility is achieved with large motorized linear stages that move the objective in the X, Y, and Z directions up to 130 mm. 360° rotation of the frontend (rotational freedom for one axis) is achieved with the combination of a motorized high precision bearing and gearing. Additionally, the modular design of the frontend, based on commercially available optomechanical parts, allows straightforward updates to future scanning technologies. The design exceeds the mobility of previous movable microscope designs while maintaining high optical performance.
Validation of Joensuu risk criteria for primary resectable gastrointestinal stromal tumors. (2010)

10018 Background: Approval of imatinib for adjuvant treatment of gastrointestinal stromal tumors (GISTs) raised discussion about accuracy of prognostic factors in GIST and the clinical significance of risk criteria. Methods: We evaluated the influence of a new modification of the NIH consensus criteria, the Joensuu risk criteria (Hum Pathol 2008;39:1411), and several clinicopathological factors on disease-free survival (DFS) in a prospective tumor registry series consisting of 549 consecutive patients diagnosed with primary, resectable, CD117-immunopositive GIST. The patients were followed up for a median of 28 months after tumor resection; none received adjuvant imatinib. Results: The median DFS time after surgery was 50 months. In univariate analyses, a high Joensuu risk group (p<0.000001), mitotic count >5/50 HPF (p<0.00001), primary tumor size >5 cm (p<0.00001), non-gastric tumor location (p=0.00001), tumor rupture (spontaneously or at surgery, present in 6.6% of cases; p=0.0014) and male gender (p=0.002) had adverse influence on DFS. In a multivariate analysis a mitotic count >5/50 HPF (HR 2.3), primary tumor size >5 cm (HR 2.0), non-gastric primary tumor location (HR 1.54) and male gender (HR 1.49) were independent adverse single prognostic factors. According to the Joensuu criteria there were 31 (5.7%), 129 (23.5%), 77 (14.0%) and 312 (56.8%) patients in the very low (VL), low (L), intermediate (I) and high (H) risk groups, respectively. Five-year DFS for the high, intermediate, low and very low risk groups was 21%, 80%, 93% and 100%, respectively. Conclusions: The Joensuu risk criteria, which include 2 additional factors to those of the NIH consensus criteria – the primary tumor site and tumor rupture - were validated as a reliable tool for assessing prognosis of primary operable GISTs. The Joensuu criteria identified particularly well high risk patients, who are proper candidates for adjuvant therapy. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Novartis, Pfizer, Schering-Plough
Jointly cooperative decode-and-forward relaying for secondary spectrum access (2012)

A new transmission protocol for joint cooperation between a primary and secondary user in a cognitive radio system is proposed. If successful decoding is achieved, the primary/secondary transmitters behave as relays for the other system. With more efficient use of the communication resource, performance is enhanced. The proposed scheme builds on the work in [1] and offers improved outage probabilities for both the primary and secondary systems. The paper provides a full characterization of the Markov Chain describing the protocol behavior and a closed form expression for the stationary distribution of the chain. Furthermore, exact computation or tight approximations for the outage probabilities for all states of the chain are derived. Simulation results exhibit a performance improvement between 22 and 48 percent for primary system and an uniform decrease of outage probability for secondary system.
Conoscopic holograms (1986)

Conoscopic holography is an incoherent holographic technique based on light propagation in uniaxial crystals. Let a monochromatic circularly polarized point source radiate light in a cone. A ray inside this cone can be decomposed in two components of equal intensity, the ordinary and extraordinary waves. The optical path differences between these two waves is given (to within a very good approximation) by a quadratic function of the angle. The pattern produced after a circular analyzer—the conoscopic pattern—is a Fresnel zone lens. Now, if an object is placed at the input of the system, the output will be the convolution of the object intensity distribution with a Fresnel zone lens, i.e., a hologram. One of the principal advantages of this technique is the possibility to record a Fresnel hologram on a TV camera and to digitize and send the data, in real time, to a computer. The system can be used directly to perform matched filtering in two or three dimensions; alternatively, the hologram can be processed by the computer to retrieve the 3-D information.
ChemInform Abstract: SYNTHESIS AND STRUCTURE‐ACTIVITY STUDY OF PROTEASE INHIBITORS. IV. AMIDINONAPHTHOLS AND RELATED ACYL DERIVATIVES (1985)

Abstract Es werden einige Amidinonaphthole und ihre Acylderivate gemäß dem Formelschema synthetisiert.
Angle-tuned, evanescently-decoupled reflector for high-efficiency red light-emitting diode (2008)

We propose and demonstrate evanescently-decoupled, solid-angle-optimized distributed Bragg reflectors (DBRs) for AlGaInP light-emitting diodes (LEDs). The thickness of each DBR layer is tuned to the wavelength slightly longer than the emission peak of the active medium in order to maximize the radiated power integrated over the top surface. In addition, to increase the horizontal radiation through the side facets, the glancing-angle reflectivity at the AlInP/AlAs interface is improved by employing an AlAs layer thicker than the attenuation length of the evanescent field. With the improved DBR, the integrated output power of AlGaInP LEDs is enhanced by a factor of 1.9 in comparison to those of LEDs with conventional DBRs. Additional 1.25-fold enhancement is observed by incorporating an square-lattice hole array (a=1200nm) into the top GaP surface by a conventional photolithography.
100G beyond Ethernet transport for inter- and intra-DCN communication with solutions and optical enabling technologies in the ICT STRAUSS project (2015)

A multi-domain optical infrastructure with end-to-end Ethernet transport capability can deliver Ethernet services over a large scale and provide a promising solution for inter data center networks (DCN) communication. The already existed metro and core networks should be evolved both in data plane and control plane towards to support the heterogeneous and dynamic Ethernet traffic environment. In this paper, we report the work carried out in the ICT STRAUSS project to provide Ethernet connections for intra-DCN and inter-DCN over metro and core networks. The key technologies for intra- and inter- DCN communications are reported with experimental validation.