gebhart/patrepeval huggingface dataset:
Time optimality, proprioception, and the triphasic EMG pattern (1989)

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What Is The Optimal Dose Of Methotrexate In Primary Central Nervous System Lymphoma Treatment Regimens? (2013)

Abstract Introduction Primary central nervous system lymphoma (PCNSL) is a rare disorder with a poor prognosis. The mainstay of treatment is single agent or combination high dose (≥3.5g/m2) methotrexate (HDMTX) based regimens. There is no consensus as to which dose of HDMTX improves outcomes in patients with PCNSL but doses of MTX greater than 3 g/m2 intravenously achieve therapeutic cerebrospinal fluid (CSF) concentrations. Purpose To determine if there is an optimal or total dose of HDMTX in PCNSL therapies that results in improved progression free (PFS) or overall survival (OS). Methods Patients at Moffitt Cancer Center with PCNSL were identified using our institutional database between January 1, 2000 and September 30, 2011. Patients with complete treatment data who were treated with HDMTX were included in this study. HDMTX was defined as MTX at a dose ≥ 3.5g/m2. Patient demographics, clinical, and treatment data were collected and analyzed. Treatment information collected included the starting dose of HDMTX, IV rituximab use, MTX toxicity and clearance, cycles of MTX, and total amount of MTX administered (g/m2). Data were analyzed using descriptive statistics and the Kaplan-Meier (KM) method was used to estimate median PFS and OS using the log rank test. P value of &lt;0.05 was considered significant. All data was analyzed using SPSS statistical software version 21.0. Results A total of 51 patients were identified (Table 1). Median PFS was 13months (0-33) and median OS 43months (29-57). The addition of IV rituximab or other chemotherapy failed to improve PFS or OS. HDMTX dose reductions or the total dose of HDMTX administered did not significantly impact PFS or OS. Similarly, when comparing dosing of HDMTX there was no significant difference in 8g/m2 versus 3.5g/m2 (PFS p=0.56, OS p=0.68), or between patients receiving 8g/m2 versus &lt;8g/m2 (PFS p=0.77, OS p=0.6) (Figure 1). Patients receiving 8g/m2 versus those receiving &lt;8g/m2 of HDMTX had similar baseline characteristics except for more liver function abnormalities in the 8g/m2 group. Conclusions Differences in initial dosing of HDMTX or total dose of HDMTX therapy did not influence outcomes in our patients with PCNSL. Dose reductions in HDMTX, addition of other chemotherapeutic agents, or rituximab were not associated with improved PFS or OS. An intriguing plateau was observed in OS in the 8gm/m2 arm despite similar PFS, suggesting that the receipt of novel therapies in the relapsed setting may contribute to OS. Multicenter collaborative clinical trials are needed to further assess the optimal initial dose of HDMTX to administer in PCNSL. Disclosures: No relevant conflicts of interest to declare.
Thermal effects in Yb-doped double-cladding Distributed Modal Filtering rod-type fibers (2012)

The effects of thermally-induced refractive index change in Yb-doped Distributed Modal Filtering (DMF) photonic crystal fibers are investigated, where high-order mode suppression is obtained by resonant coupling with high index elements in the cladding. The temperature distribution on the fiber cross-section is calculated with an analytical model, for different pump power values. The consequent refractive index change, due to the thermo-optical effect, is applied to the cross-section of the DMF fiber, whose guiding properties are studied with a full-vector modal solver based on the finite element method. A DMF fiber design, which is single-mode in the 1030 nm-1064 nm region, is considered, and the effects of thermal load on the transmission characteristics are evaluated. Results show a blue-shift of the single-mode window and the single-mode bandwidth narrowing as the absorbed pump power becomes higher.
Cross-Reactive Optical Sensing Arrays (2002)

Vertebrate olfaction and gustation, noted for their sensitivity and selectivity, provide intriguing models for creating cross-reactive sensor arrays. To mimic these sensing systems, a sensor array was developed comprising thousands of bead sensors, randomly dispersed across an etched optical fiber array. These bead sensors are impregnated with solvatochromic dyes, which alter their fluorescence emission spectra in response to microenvironmental changes due to the analyte's polarity. Each sensor type is cross-reactive and has unique fluorescence response patterns to different analytes. Such a sensor array can quickly accommodate new bead types and is an improvement over other sensors in terms of size, response and recovery times, ease of preparation, sensitivity, and reproducibility. Possible applications range from pollution monitoring, medical diagnosis, food quality control, and land-mine detection.
Comparison of Multimodal Therapies and Outcomes Among Patients With High-Risk Prostate Cancer With Adverse Clinicopathologic Features (2021)

These findings suggest that among patients with high-risk prostate cancer and additional unfavorable clinicopathologic features receiving guideline-concordant multimodal therapy, prostate cancer-specific mortality outcomes were equivalent among those treated with RP, EBRT, and EBRT with BT, although distant metastasis outcomes were more favorable among patients treated with EBRT and EBRT with BT. Optimal multimodality treatment is critical for improving outcomes in patients with high-risk prostate cancer.
CD8+NKR-P1A+ T cells preferentially accumulate in human liver (1999)

A unique subset of T cells that co-express NKR-P1, which is a lectin type of NK receptor and is thought to have a major role in triggering NK activity, has been identified. In mice, NK1.1 (mouse NKR-P1C)(+) T cells, called NKT cells, preferentially accumulate in the liver and bone marrow. They predominantly use invariant Valpha14 chain TCR and phenotypically are CD4(+)CD8(-) or CD4(-)CD8(-) T cells. In this study, we analyzed, phenotypically and functionally, the NKR-P1A (analogue of murine NKR-P1C)(+) T cells resident in the human liver. Here, we show that in complete contrast to the NKT cells in the mouse liver, the majority of NKR-P1A(+) T cells in the human liver are CD8(+) and their TCR repertoire is not skewed to Valpha24 TCR, the homologue of murine Valpha14 TCR. Almost all of the NKR-P1A(+) T cells in the human liver expressed CD69, suggesting that they were activated. Furthermore, the NKR-P1A(+) T cells in the human liver exhibited strong cytotoxicity against a variety of tumor cell lines including K562, Molt4 and some colonic adenocarcinoma cell lines.
Anterior Selective Amygdalohippocampectomy (2010)

In Brief OBJECTIVE We introduce a technique for performing a selective amygdalohippocampectomy (AH) through a minisupraorbital approach. METHODS A minisupraorbital craniotomy and an anterior selective AH were performed in 8 cadaver heads (16 sides). The anatomic specimens were analyzed, and the extent of resection of the hippocampus and amygdala was evaluated. Surgically relevant measurements were performed using anatomic specimens. An image-guided system was used to document the extent of the anterior AH. Laboratory data were used to support the clinical application of the technique. RESULTS The anterior route allowed removal of the amygdala and hippocampus, as confirmed by anatomic assessment. The image-guided system and anatomic evaluation confirmed that the amygdala and hippocampus can be accessed and removed through this route. The mean distance between the anterior aspect of the uncus and the tip of the temporal horn was 17.0 ± 4.6 mm; the mean distance from the head of the hippocampus to the posterior border of the cerebral peduncles was 26.0 ± 3.2 mm. Clinical application resulted in satisfactory removal of the amygdala and hippocampus. CONCLUSION The anterior route for selective AH is a logical and straightforward approach to the mesial temporal lobe. Compared with other variations, it is less invasive and destructive, especially in terms of the fibers of the optic pathway, temporal stem, and lateral temporal neocortex. On the Cover While technology pushes operative techniques forward, a similar impact can be observed in the world of graphic design. This cover was not painstakingly rendered after weeks of trials and tribulations, but instead was automated by a commercially-available Adobe Photoshop action. Developed by PanoFX, the Panos Cubes action allows a graphic designer to select images and render them onto the face of a 3-D cube. The cube figures were selected from both this issue and the December issue of Operative Neurosurgery. The process takes seconds.
An autonomous cooperative system for material handling applications (2000)

The key to the creation of flexible automation is to use inherent redundancy in the capabilities of the system being controlled. This requires the control system to be continuously self-configurable under varying conditions. The ability of the control system to react to and predict changes will ultimately determine the economic viability of that system. In this paper, an Autonomous Cooperative System to control material handling systems is presented. Important components of the material handling system are combined with intelligence and autonomy rules to flexibly control the operations of the physical equipment. Control is carried out while the overall operation of the system is optimized through cooperation among the controlled sections. The operation of the material handling system is observed during conditions of equipment and product changes. The results from simulation show how an Autonomous Cooperative System can be used to reduce the impact of changes in material handling applications.
C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis (2004)

Immune complex (IC)-induced inflammation is integral to the pathogenesis of several autoimmune diseases. ICs activate the complement system and interact with IgG FcgammaR. In this study, we demonstrate that activation of the complement system, specifically generation of C5a, initiates the neutrophilic inflammation in IC peritonitis. We show that ablation of C5a receptor signaling abrogates neutrophil recruitment in wild-type mice and prevents the enhancement of neutrophil migration seen in FcgammaRIIB(-/-) mice, suggesting that C5aR signaling is the crucial initial event upstream of FcgammaR signaling. We also provide evidence that C5a initiates the inflammatory cascade both directly, through C5aR-mediated effector functions on infiltrating and resident peritoneal cells, and indirectly, through shifting the balance between activating and inhibitory FcgammaRs on resident cells toward an inflammatory phenotype. We conclude that complement activation and C5a generation are prerequisites for IC-induced inflammation through activating FcgammaR, which amplifies complement-induced inflammation in autoimmunity.
ChemInform Abstract: New Highly Stereoselective Synthesis of (Z)‐4‐Hydroxytamoxifen (VIa) and (Z)‐4‐Hydroxytoremifene (VIb) via McMurry Reaction. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model (2022)

Our data support the rational design of immunotherapeutic strategies targeting CSC to optimize their responsiveness to local CD8<sup>+</sup>CD103<sup>+</sup> T<sub>RM</sub> cells for more efficient anticancer treatments.
Sequence-Selective Targeting of Long Stretches of the DNA Minor Groove by a Novel Dimeric Bis-benzimidazole (2003)

A dimeric bis-benzimidazole molecule has been designed by computer modeling to bind to a DNA sequence via the DNA minor groove that covers a complete turn of B-DNA. A series of bis-benzimidazole dimers incorporating a -O-(CH(2))(n)()-X-CH(2))(n)()-O- linker, with n = 2 or 3 and X = O or N(+)H(Me), were screened for their capacity to fit the DNA minor groove. The modeling studies enabled an optimal linker to be devised (n = 3, X = N(+)H(Me)), and the synthesis of the predicted "best" molecule, N-methyl-N,N-bis-3,3-[4'-[5' '-(2' "-p-methoxyphenyl)-5' "-1H-benzimidazolyl]-2' '-1H-benzimidazolyl]phenoxypropylamine (5), is reported. The optimized linker permits the two symmetric bis-benzimidazole motifs to maintain hydrogen-bonded contacts with the floor of the DNA minor groove. DNase I footprinting studies have shown that this ligand binds with high affinity to sequences representing approximately a complete turn of B-DNA, represented by the [A.T](4)-[G.C]-[A.T](4) motif, and only poorly to sequences of half this site size, in accord with the computer modeling studies. Compound 5 does not show acute cellular cytotoxicity, in contrast with its monomeric bis-benzimidazole precursors, yet is rapidly taken up into cells.
Evasive Internet: Reducing Internet Vulnerability through Transient Addressing (2010)

This paper presents our vision for Evasive Internet, where destinations are only reachable through capabilities, which serve as hosts' flat transient addresses. Just as today's host addresses, our capabilities are obtained from the DNS hierarchy, thus never exposing destinations themselves to unprotected traffic. Our design supports in-network authentication of transient addresses and attribution of traffic they generate; our design further gives hosts full control over incoming flows. We achieve these objectives without exposing hosts to unprotected capability request traffic and without distributed filtering infrastructure. While significant work is needed to flesh out our vision, we hope it will contribute to improving security in future networks.
Der gleichläufige Doppelschneckenextruder (2016)

You have accessDer gleichläufige DoppelschneckenextruderOct 2016Der gleichläufige DoppelschneckenextruderKlemens KohlgrüberKlemens KohlgrüberSearch for more papers by this authorhttps://doi.org/10.3139/9783446435971.fmSectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn next chapter FiguresReferencesRelatedDetails 2016Pages: I-XXIIIPrint ISBN: 978-3-446-43361-8eISBN: 978-3-446-43597-1 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Strain and Temperature Sensitivity of Beatlength in a Dual-Core Microstructured Polymer Optical Fiber (2015)

Microstructured polymer optical fibers (mPOFs) offer advantages in many sensing applications due to their large strain capability compared with silica fibers [1]. Dual-core mPOFs have also been shown to be very sensitive to the refractive index of materials infiltrating the microstructure [2], with applications in biomedical sensing [3]. A common problem in sensing applications is the separation of the various extraneous effects (especially temperature and strain) which can modify propagation in the mPOF, and hence may cause significant sensing errors. For this reason it is necessary to understand and quantify the sensitivity of dual-core mPOFs to strain and/or temperature. It may also be possible to utilise dual-core mPOFs for sensing temperature and/or strain [4], or as tunable couplers.
A Candidate Cell-Selective Anticancer Agent (2014)

Lung cancer remains a major cause of cancer death in the United States and world-wide. Therapies targeted to tumor-specific genomic alterations may hold the most promise for the future, yet no one has successfully leveraged the most commonly mutated gene in lung cancer, TP53. We have taken a synthetic lethal approach, aiming to identify small molecules that are specifically lethal to TP53 mutant cancer cells. We screened a library of 2000 small molecules for cytotoxic effects in TP53 mutant and wild-type lung adenocarcinoma cell lines and identified one compound, CID 2874250, which selectively killed the TP53 mutant cell line. In a panel of thirty-two cancer cells lines CID 2874250 was very potent (EC50 < 20 nM) against a subset of TP53-mutant (or functionally inactive) cells, including the H1563, H2122, H1734, and HeLa cell lines. The compound was inactive against the remaining cell lines, including immortalized but nontumorigenic cell lines. Separation of enantiomers demonstrated that one enantiomer was responsible for the observed cellular activity. Commercially available analogs of CID 2874250 provided limited SAR.Synthetic chemistry established the absolute stereochemistry of the active enantiomer of CID 2874250. Medicinal chemistry efforts created a library of approximately fifty analogs which were tested against sensitive HeLa cells (TP53 mutant) and insensitive A549 cells (TP53 wild type). Activity was improved with these highly soluble, low molecular weight compounds. Undesirable groups, e.g a nitro group, were removed, and metabolic stability was increased. The more active analogs, including the probe ML379, displayed low nM activity in a larger panel of TP53 mutant cell lines. Activity was observed in a murine xenograph experiment.The initial lead, CID 2874250, significantly inhibited only PDE3 isoforms in a PDE panel. An affinity resin with an analog pulled down predominantly PDE3A from lysed HeLa cells. These results suggest a hitherto unknown role for PDE3 in certain cancer cells.
Structural Damage Detection using Wireless Sensor-Actuator Networks (2005)

Structural health monitoring (SHM) is a well-established multi-disciplinary research field, in which the goal is to develop technologies and techniques to automatically detect, localize, and classify damage in large structures. This paper is focused, starting with a simple SHM problem and a simple structure, on how wireless sensor networking technologies can help advance SHM. Specifically, a distributed damage detection algorithm is developed based on shifted spectra of response at the sensor nodes. While damage detection using frequency shifts is fairly well-understood in the SHM community, the development here adheres to sensor network architectural principles: the technique is amenable to in-network processing and duty-cycling, and can be implemented on a long-running sensor network. The efficacy is demonstrated using simulations on structural models, and actual measurements on real, albeit simple, structures
BslA, a pXO1‐encoded adhesin of Bacillus anthracis (2008)

The Gram-positive pathogen Bacillus anthracis causes anthrax, a fulminant and lethal infection of mammals. Two large virulence plasmids, pXO1 and pXO2, harbour genes required for anthrax pathogenesis and encode secreted toxins or provide for the poly gamma-d-glutamic acid capsule. In addition to capsule, B. anthracis harbours additional cell wall envelope structures, including the surface layer (S-layer), which is composed of crystalline protein arrays. We sought to identify the B. anthracis envelope factor that mediates adherence of vegetative forms to human cells and isolated BslA (B. anthracisS-layer protein A). Its structural gene, bslA, is located on the pXO1 pathogenicity island (pXO1-90) and bslA expression is both necessary and sufficient for adherence of vegetative forms to host cells. BslA assembly into S-layers and surface exposure is presumably mediated by three N-terminal SLH domains. Twenty-three B. anthracis genes, whose products harbour similar SLH domains, may provide additional surface molecules that allow bacilli to engage cells or tissues of specific hosts during anthrax pathogenesis.
ChemInform Abstract: Complexation of Gold(I) Thiomalate (′Myocrisin′) with 1,3‐Diazinane‐2‐thione in Aqueous Solution Followed by 13C Nuclear Magnetic Resonance Spectroscopy. (1986)

Abstract It is shown that the anti‐arthritic drug gold(I) thiomalate forms a l :l complex with 1,3‐diazinane‐2‐thione (L) at pH 7.2.
10.1: Invited Paper: Importance of Interface Control in Solution Processed Organic Light Emitting Diodes (2021)

It is very difficult to realize highly efficient and stable solution processed organic light emitting diodes (OLEDs) due to an interface mixing behavior during continuous wet processes. To eliminate this problem, we need to form a cross‐linkable hole transport layer (x‐HTL) before depositing an emitting layer (EML). However, we cannot clearly solve interface mixing problem although we use such x‐HTL during process. Especially, we found that the crosslinking of HTL causes serious reduction of hole mobility, which results in shift of exciton formation zone toward HTL / EML interface. Thus, we need to focus on EML composition because the interface mixing could be accelerated if the thermal stability of materials in EML is very poor. In other words, small molecules in EML often diffuse into the preceding HTL although it's crosslinked. Besides, we also found that the thermal stability of host materials in EML is very important for this interface mixing behavior.
Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy (2021)

The purpose of this work is to show the usefulness of a prediction method of tumor location based on partial least squares regression (PLSR) using multiple fiducial markers. The trajectory data of respiratory motion of four internal fiducial markers inserted in lungs were used for the analysis. The position of one of the four markers was assumed to be the tumor position and was predicted by other three fiducial markers. Regression coefficients for prediction of the position of the tumor-assumed marker from the fiducial markers' positions is derived by PLSR. The tracking error and the gating error were evaluated assuming two possible variations. First, the variation of the position definition of the tumor and the markers on treatment planning computed tomograhy (CT) images. Second, the intra-fractional anatomical variation which leads the distance change between the tumor and markers during the course of treatment. For comparison, rigid predictions and ordinally multiple linear regression (MLR) predictions were also evaluated. The tracking and gating errors of PLSR prediction were smaller than those of other prediction methods. Ninety-fifth percentile of tracking/gating error in all trials were 3.7/4.1 mm, respectively in PLSR prediction for superior-inferior direction. The results suggested that PLSR prediction was robust to variations, and clinically applicable accuracy could be achievable for targeting tumors.