gebhart/patrepeval huggingface dataset:
Class 1 and 2 Integrons in Hospital Strains of Gram-Negative Bacteria Isolated in Moscow and in Regions of the Russian Federation (2019)

Natural systems of cloning and expression of mobile gene cassettes caught by site-specific recombination, class 1 and 2 integrons, play an important role in mobilization and spread of genetic determinants of antibiotic resistance in gram-negative bacterial human pathogens, especially in a hospital environment. The gene cassettes localized in variable parts of integrons determine resistance to antibacterial drugs (AD) of different functional classes. The aim of the work is the detection and characteristic of class 1 and 2 integrons in gram-negative bacteria isolated in multidisciplinary hospitals of Moscow and other regions of the Russian Federation in 2003–2015. Clinical strains of gram-negative bacteria (n = 1248) mainly had multidrug resistance phenotype (94%). An amount of 10% of strains were resistant to AD of three functional groups; 19%, four; 42%, five; 17%, six; and 7%, seven. A high level of resistance of the studied strains to beta-lactams is associated with the presence of beta-lactamase genes of blaTEM (35% strains), blaSHV (25%), blaCTX-M (38%), blaOXA (31%), blaVIM (3%), and blaNDM (2%) types; to AD of other functional groups, with the presence of class 1 integrons (59%) and class 2 integrons (8%). Most class 1 integrons (54%) and class 2 integrons (88%) contained in its variable part 22 variants of gene cassette arrays in class 1 integrons and 4 variants in class 2 integrons. During the study, 31 types of gene cassettes were identified (including the most widespread, aadB, aacA4, aacC1, aadA1, aadA2, aadA5, blaVIM-2, dfrA1, dfrA7, dfrA12, orfC, orfE, orfY, and sat1) associated with the resistance of strains to aminoglycosides, chloramphenicol, sulfonamides, and beta-lactams, as well as orf cassettes encoding the proteins with unknown functions. New gene cassette arrays were identified: dfrA12s-orfF-aadA2 (In1249) and dfrA1-IS911-sat1-aadA1 (not numbered).
Dihydrogen Complexes of Iridium and Rhodium (2012)

A series of iridium and rhodium pincer complexes have been synthesized and characterized: [(POCOP)Ir(H)(H(2))] [BAr(f)(4)] (1-H(3)), (POCOP)Rh(H(2)) (2-H(2)), [(PONOP)Ir(C(2)H(4))] [BAr(f)(4)] (3-C(2)H(4)), [(PONOP)Ir(H)(2))] [BAr(f)(4)] (3-H(2)), [(PONOP)Rh(C(2)H(4))] [BAr(f)(4)] (4-C(2)H(4)) and [(PONOP)Rh(H(2))] [BAr(f)(4)] (4-H(2)) (POCOP = κ(3)-C(6)H(3)-2,6-[OP(tBu)(2)](2); PONOP = 2,6-(tBu(2)PO)(2)C(5)H(3)N; BAr(f)(4) = tetrakis(3,5-trifluoromethylphenyl)borate). The nature of the dihydrogen-metal interaction was probed using NMR spectroscopic studies. Complexes 1-H(3), 2-H(2), and 4-H(2) retain the H-H bond and are classified as η(2)-dihydrogen adducts. In contrast, complex 3-H(2) is best described as a classical dihydride system. The presence of bound dihydrogen was determined using both T(1) and (1)J(HD) coupling values: T(1) = 14 ms, (1)J(HD) = 33 Hz for the dihydrogen ligand in 1-H(3), T(1)(min) = 23 ms, (1)J(HD) = 32 Hz for 2-H(2), T(1)(min) = 873 ms for 3-H(2), T(1)(min) = 33 ms, (1)J(HD) = 30.1 Hz for 4-H(2).
Comparative analysis of Nuclear Magnetic Resonance and Whole Angle Coriolis Vibratory Gyroscopes (2014)

This paper's focus is a theoretical comparison of Nuclear Magnetic Resonance Gyroscope (NMRG) and Whole-Angle (WA) Coriolis Vibratory Gyroscopes (CVG) dynamics, showing the parallels in structure of basic equations and deriving performance scaling laws. The comparison relies on the method of averaging to derive the linearized equations of motion and analytical solutions for both types of sensors. While equations for WA CVG in terms of slow-varying components have been extensively published in literature, the contribution of this work is derivation of the linearized equations of motion for NMRG using the method of averaging, as well as its comparison to the WA CVG dynamics. Finally, the paper identifies “optimization knobs” for the two types of sensors (e.g., ring-down time for CVG and relaxation time for NMRG) and discusses similarities and dissimilarities in their dynamics.
Nonionic Block Copolymer Wormlike Micelles (2007)

Block copolymers are macromolecules composed of chemically distinct blocks that are covalently linked together. Molecular architectures that can be produced using the simplest combination of two types of monomers (A and B) include diblock (A-B) and triblock (A-B-A) copolymers. The viscoelastic surfactant phase usually contains long flexible entangled cylindrical aggregates often referred to as wormlike, threadlike, rodlike, or giant micelles. Speculation regarding wormlike micelles in surfactant solutions dates as far back as the early 1950s. A wormlike micelle morphology also has been associated with block copoly-mers in nonaqueous solvents. The chapter summarizes examples of proofs of concepts for new applications of block copolymer-based wormlike micelles. Amphiphilic self-assembly results in a variety of nanostructures in surfactant solutions: micelles and vesicles at low concentrations, and various liquid-crystalline morphologies in the high-concentration regime. Analogous considerations have been advanced to analyze the micellar aggregation behavior of non-charged block copolymers in selective solvents.
Lithographic Deposition of Patterned Metal–Organic Framework Coatings Using a Photobase Generator (2014)

Abstract A photobase generator was used to induce metal–organic framework (MOF) nucleation upon UV irradiation. This method was further developed into a simple, one‐step method for depositing patterned MOF films. Furthermore, the ability of our method to coat a single substrate with MOF films having different chemical compositions is illustrated. The method is an important step towards integrating MOF deposition with existing lithographic techniques and the incorporation of these materials into sensors and other electronic devices.
Prevalence of tracheobronchomalacia in young children with cystic fibrosis (2012)

Tracheobronchomalacia (TBM) is a commonly diagnosed condition with incidence in general population ranging between 1 in 1400 to 1in 2100 children.In a recent study of adults with cystic fibrosis (CF) by using multi detector CT scans a high prevalence of 29% was reported. Aim: To study the prevalence of tracheobronchomalacia in children with CF. Methods: A prospective observational study was done in Princess Margaret Hospital Perth, Australia from Jan 2011 to Dec 2011.Bronchoscopy findings recorded by clinician were collected in children undergoing CT chest and bronchoalveolar lavage as part of a surveillance programme (ARESTCF) in children with CF 6 years and below. A subjective visual estimation of 50% reduction in cross sectional area was used for defining TBM during breathing efforts. Results: A total of 72 children were studied over 1 year. A prevalence rate of 13.9% was found in the age group studied. Highest prevalence was found during first 2 years (22.7%). Limitations: prevalence could have been underestimated as spontaneous breathing was not observed in some children due to anaesthetic factors. As technique used was visual estimation there is a potential for observer bias. Conclusions: A high prevalence of tracheo broncho malacia was found in young children with CF. There is a need for further studies to understand the significance of tracheomalacia in CF. Acknowledgements: Perth division of ARESTCF programme.
Assessing the role of IKCa channels in generating the sAHP of CA1 hippocampal pyramidal cells (2016)

Our previous work reported that KCa3.1 (IKCa) channels are expressed in CA1 hippocampal pyramidal cells and contribute to the slow afterhyperpolarization that regulates spike accommodation in these cells. The current report presents data from single cell RT-PCR that further reveals mRNA in CA1 cells that corresponds to the sequence of an IKCa channel from transmembrane segments 5 through 6 including the pore region, revealing the established binding sites for 4 different IKCa channel blockers. A comparison of methods to internally apply the IKCa channel blocker TRAM-34 shows that including the drug in an electrode from the onset of an experiment is unviable given the speed of drug action upon gaining access for whole-cell recordings. Together the data firmly establish IKCa channel expression in CA1 neurons and clarify methodological requirements to obtain a block of IKCa channel activity through internal application of TRAM-34.
Acupuncture for the Treatment of Allergic Rhinitis: A Systematic Review and Meta-Analysis (2015)

Our meta-analysis suggests that that acupuncture could be a safe and valid treatment option for AR patients.
The possibility of diamond sintering by hydrothermal hot-pressing (2006)

Very fine diamond was synthesized under hydrothermal conditions, with new bond formation among diamond particles, in 10M‐NaOH solution at 573K, 1GPa, for 24 hours. This new bonding material is formed by carbonization, from chlorinated hydrocarbon such as dichloromethane and 1,1,1‐trichloroethane, under alkaline hydrothermal conditions. The carbonized material forms a new bond between diamond particles by the release of hydrogen‐chloride using a hydrated diamond powder particle as the starting material. With pellet of compacted diamond, the platy materials were produced. These materials were diamond by micro‐XRD analysis. New growth materials between compacted diamonds, and each diamond particles were bonded. Therefore, it is possible that compacted diamonds is sintered by carbon‐bonds under hydrothermal synthesis. Hydrothermal hot‐pressing is technic that materials as glass, calcium silicate and calcium carbonate is solidified. Compacted materials is deformed under hydrothermal conditions, and materials is solidified strongly by alterative materials. This technic can be applied to diamond sintering.
Screw Fixation Compared to H-Locking Plate Fixation for First Metatarsocuneiform Arthrodesis: A Biomechanical Study (2005)

Screw fixation for first MTC arthrodesis created a stronger and stiffer construct than did the H-locking plate. This was likely due to the mechanical design of the implants. Compression across the MTC joint could be applied with the screws, but the plate relied on a fixed angle design with no compression.
Fluorescence detection of fibrillar proteins on silicon microstructures (2011)

The biology and the structure of amyloid fibrils are under extensive investigation in many laboratories: they are co-causative agents of diseases such as Parkinson's and Alzheimer's. We are investigating the use of a silicon micromachined structure, fabricated by electrochemical etching, as a three-dimensional supporting matrix also suitable for optically monitoring the amyloid fibrils growth. The silicon device consists in a periodic array of silicon walls with high aspect-ratio. This periodic arrangement of silicon and air gives rise to one-dimensional hybrid photonic crystals, suitable for out-of-plane (top view) imaging but, potentially, also for in-plane label-free testing. Here, we present some preliminary results relative to fluorescence microscopy analysis performed to investigate the interaction among silicon microstructures and fibrillar proteins. Samples of the highly amyloidogenic variant of human β2-microglobulin (P32G β2-m) are deposited on flat silicon dice as well as inserted into the gaps of the micromachined silicon devices. After Thioflavin T labeling, a bright emission originating only from silicon devices where polymerized amyloid fibrils are present is observed.
Forced Convective Boiling of Ethylene Glycol/Water Mixtures Inside a Small Tube (2012)

Forced convective boiling heat transfer of water and ethylene glycol/water mixtures with volume concentration ratios of 40/60, 50/50, and 60/40 in a 2.98-mm inner-diameter circular tube has been investigated for both horizontal and vertical upward flows. Boiling heat transfer rates of the test fluids were determined experimentally over a range of mass flux, vapor mass quality, and inlet subcooling through a boiling data reduction procedure that allowed analytical calculation of the fluid boiling temperatures along the experimental test section by applying ideal mixture and equilibrium assumptions along with Raoult's law. Based on the experimental findings that the heat flux in the nucleation-dominant-boiling region was dependent strongly on the wall superheat but almost independent of the mass flux and the inlet subcooling, prediction equations were developed for boiling heat transfer coefficients of water and ethylene glycol/water mixtures in small channels. The equations predict the experimental data well, and most of the predicted values are within ±30 % of the experimental data.
Regulation of Transcription by AMP-activated Protein Kinase (2001)

AMP-activated protein kinase (AMP-kinase) modulates many metabolic processes in response to fluctuations in cellular energy status. Although most of its known targets are metabolic enzymes, it has been proposed that AMP-kinase might also regulate gene expression. Here we demonstrate that the transcriptional coactivator p300 is a substrate of AMP-kinase. Phosphorylation of p300 at serine 89 by AMP-kinase dramatically reduced its interaction, in vitro and in vivo, with the nuclear receptors peroxisome proliferator-activated receptor gamma, thyroid receptor, retinoic acid receptor, and retinoid X receptor, but did not affect its interaction with the non-nuclear receptor transcription factors E1a, p53, or GATA4. These findings indicate that the AMP-kinase signaling pathway selectively modulates a subset of p300 activities and represent the first example of a transcriptional component regulated by AMP-kinase. Our results suggest a direct link between cellular energy metabolism and gene expression.
ChemInform Abstract: Studies on the Ring Opening Reactions of 3‐Oxa‐1‐azabicyclo[3.1.0]hexan‐2‐ones. Synthesis of Aminomethyl Oxazolidinones and Aziridinyl Ureas. (2012)

Abstract The product ratio strongly depends on the polarity of the solvent, cf.
An Analysis of a Wire-Wrapped Mechanical Crack Arrester for Pressurized Pipelines (1979)

Peer Reviewed
Chip-Scale Near-Field Resonant Power Transfer via Elastic Waves (2017)

This paper reports on the proof-of-concept demonstration of an approach for the synthesis of a through package charging and authenticating communication link enabled by GHz-range aluminum nitride (AlN) piezoelectric transducers. The acoustic link is formed by two thickness-mode acoustic transducers placed on the two sides of a packaging substrate. The link leverages the enhancement of energy transfer that occurs at resonance; 1-μm-thick (2.7 GHz) and 6-μm-thick (500 MHz) AlN acoustic links are demonstrated showing substantial enhancement of power transfer efficiencies (PTE) when using thicker AlN substrates. PTEs of -8 dB at 2.7 GHz and -2 dB at 500 MHz are measured for transducers' size of 1×100 × 100 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> and 6×100 × 100 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> through 700and 500-μm-thick silicon substrates, respectively. The experimental values are in very close agreement with the analytical model of the acoustic link. The potential misalignment between the two transducers is the main limitation of this approach. To overcome this challenge, acoustic phased arrays are devised to enable steering of the transmitted beam. Preliminary results on the steering capability demonstrate about 8 dB of improvement in PTE via a two-element array when dealing with a 100-μm misalignment. This paper is the first step toward the development of next-generation high-efficiency and micro-scale power transfer units that could energize chips through packages.
Improving lithographic performance for 32 nm (2010)

As optical lithography pushes towards the 32nm node and as the k<sub>1</sub> factor moves toward 0.25, scanner performance and operational stability are the key enablers to meet device scaling requirements. Achieving these requirements in production requires stable lithography tools and processes. Stable performance is tracked with respect to pattern to pattern overlay, nominal focus and critical dimension uniformity (CDU). Within our paper we will characterize the intrinsic lithographic performance of the scanner and will discuss a new method of machine control to improve the stability and thus the overall performance of the lithographic solution. This is achieved by measuring specific monitor wafers, modeling the results by a new software algorithm and constantly feeding back corrective terms to the scanner. Diffraction-based optical dimensional scatterometry was selected because of its precision, its ability to measure overlay and focus with a single metrology recipe and its capability to generate greater amounts of measurement data in a shorter time period than other metrology techniques and platforms. While monitor wafer performance can be indicative, we will discuss the impact of the new control loop on product. We will take a closer look at possible interactions with the existing process control loops and work through the configuration of both internal and fab control loops. We will show improvements in the focus performance on product wafers by using scatterometry as well. Most importantly we will demonstrate that the newly implemented control loop resulted in a significant improvement of the CD and overlay performance of critical product layers. This had a very positive impact on overall process variation and the rework rate at lithography.
Physical mechanisms of the therapeutic effect of ultrasound (a review) (2003)

Therapeutic ultrasound is an emerging field with many medical applications. High intensity focused ultrasound (HIFU) provides the ability to localize the deposition of acoustic energy within the body, which can cause tissue necrosis and hemostasis. Similarly, shock waves from a lithotripter penetrate the body to comminute kidney stones, and transcutaneous ultrasound enhances the transport of chemotherapy agents. New medical applications have required advances in transducer design and advances in numerical and experimental studies of the interaction of sound with biological tissues and fluids. The primary physical mechanism in HIFU is the conversion of acoustic energy into heat, which is often enhanced by nonlinear acoustic propagation and nonlinear scattering from bubbles. Other mechanical effects from ultrasound appear to stimulate an immune response, and bubble dynamics play an important role in lithotripsy and ultrasound-enhanced drug delivery. A dramatic shift to understand and exploit these nonlinear and mechanical mechanisms has occurred over the last few years. Specific challenges remain, such as treatment protocol planning and real-time treatment monitoring. An improved understanding of the physical mechanisms is essential to meet these challenges and to further advance therapeutic ultrasound.
Passive mode locking of homogeneously and inhomogeneously broadened lasers (1992)

We describe self-starting passive mode locking of a cw inhomogeneously broadened laser and compare its characteristics with those of a passively mode-locked homogeneously broadened laser using different Nd-doped glasses as the active material. Broadband gain media with homogeneously broadened transitions are found to be superior to those broadened inhomogeneously for passively mode-locked lasers.
Holographic pancake optics for thin and lightweight optical see-through augmented reality (2021)

Holographic pancake optics have been designed and fabricated in eyewear display optics literature dating back to 1985, however, a see-through pancake optic solution has not been demonstrated to date. The key contribution here is the first full-color volume holographic pancake optic in an optical see-through configuration for applications in mobile augmented reality. Specifically, the full-color volume holographic pancake is combined with a flat lightguide in order to achieve the optical see-through property. The fabricated hardware optics has a measured field of view of 29 degrees (horizontal) by 12 degrees (vertical) and a measured large eyebox that allows a ±10 mm horizontal motion and ∼±3 mm vertical motion for a 4 mm diameter pupil. The measured modulation transfer function (average orientation) is 10% contrast at 10 lp/deg. Three holograms were characterized with respect to their diffraction efficiency, angular bandwidth, focal length, haze, and thickness parameters. The phase function in the reflection mode hologram implements a spherical mirror that has a relatively simple recording geometry.
Bidirectional Converter Using Multistage FET Driving technique with voltage balance function (2018)

This paper presents a bidirectional convert using by multistage FET driving technique with voltage balance function. The voltage balance function can reduce influence of the voltage unbalance phenomenon which drain voltage fluctuation depending on output current. The voltage unbalance phenomenon is clarified by using an equivalent circuit of FETs connected in series. The necessity of voltage balance function is discussed, and verified in experiment. The experimental results have proven that the bidirectional converter by using the driving technique can achieve 98% or more power conversion efficiency from 170 W to 1000 W of power range, and a maximum power conversion efficiency of 99.2%.
Pathways of development of human dendritic cells. (1998)

Dendritic cells (DC) are professional antigen-presenting cells necessary for the initiation of immune responses [1]. They are derived from the bone marrow and exist in trace amounts; they are characterised by a high expression of class II major histocompatibility complex (MHC) antigens and a dendritic morphology. They form a network present in: a) several zones of non-lymphoid tissues such as Langerhans cells of epithelia (skin, [...]
A Semantic Model to Assist Policy Refinement Mechanisms for NFV-MANO Systems (2021)

Management in NFV scenarios is a complex task. In this scenario, automated policy refinement can be used to enforce NFV-MANO functions to deal with the increased complexity. However, existing solutions do not perform policy analysis. Therefore, in this work, we propose a semantic model in OWL 2, named Onto-Planner, to assist the policy refinement process for NFV-MANO systems. Preliminary results show that Onto-Planner provides policy analysis when a DL reasoner is applied.
Comunicazioni di massa e percezione dei giovani in età scolare: il caso della cultura alimentare (2005)

il volume tenta di analizzare i vissuti dei bambini in età scolare, partendo da una analisi panoramica sulle attività che scandiscono il loro tempo libero. a supporto dell'analisi sono riportati anche dati statistici di come stiano con il tempo trasformandosi i tempi dell'infanzia. l'elmento delle nuove tecnologie costituisce un attrattiva sempre maggiore per le giovani generazioni che appaiono sempre più alfabetizzati ai linguaggi del sistema dei media. il frame teorico del presente lavoro si colloca, partendo dall'analisi delle teorie sulla comunicazione di massa, nell'iquadramento del ruolo dei media all'interno dei processi di socializzazione dei minori. il libro si concentra poi sull'analisi della percezione dei flussi comunicativi, e non dei processi di persuasione, volendo in questo modo sottolineare la capacità produttiva dei fruitori televisivi non più solo semplici telespettatori, ma prima di tutto interpreti , selezionatori di flussi comunicativi, con particolare riferimento alla trasmissione di contenuti inerenti alla cultura alimentare.