gebhart/patrepeval huggingface dataset:
Sculpting narrowband Fano resonances inherent in the large-area mid-infrared photonic crystal microresonators for spectroscopic imaging (2014)

Fourier transform infrared (FT-IR) imaging spectrometers are almost universally used to record microspectroscopic imaging data in the mid-infrared (mid-IR) spectral region. While the commercial standard, interferometry necessitates collection of large spectral regions, requires a large data handling overhead for microscopic imaging and is slow. Here we demonstrate an approach for mid-IR spectroscopic imaging at selected discrete wavelengths using narrowband resonant filtering of a broadband thermal source, enabled by high-performance guided-mode Fano resonances in one-layer, large-area mid-IR photonic crystals on a glass substrate. The microresonant devices enable discrete frequency IR (DF-IR), in which a limited number of wavelengths that are of interest are recorded using a mechanically robust instrument. This considerably simplifies instrumentation as well as overhead of data acquisition, storage and analysis for large format imaging with array detectors. To demonstrate the approach, we perform DF-IR spectral imaging of a polymer USAF resolution target and human tissue in the C-H stretching region (2600-3300 cm(-1)). DF-IR spectroscopy and imaging can be generalized to other IR spectral regions and can serve as an analytical tool for environmental and biomedical applications.
Power GaN-based Microwave Devices for Wireless Communications (2001)

Gallium Nitride (GaN) based HEMTs have the potential for being the highest performance power compound semiconductor microwave transistors. In this paper, we review the performance and present results on device scaling for the AlGaN-GaN HEMTs. In particular, 1 and 2 mm wide HEMTs resulted in 8.5 W and 14.5 W output power respectively at X-band with close to 40 % power added efficiency.
Supplementary Figure 3A from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;Amplification plot demonstrating the successful HPV amplification and enrichment obtained with dual sequence capture. Delta Ct values for HeLa (pink/red) and CSCC7 (purples) were 14.88 and 12.66, respectively. Based on an estimated efficiency for the assay, the approximate fold enrichment was greater than 1700.&lt;/p&gt;
Nutrient Dependence of RNase E Essentiality in Escherichia coli (2012)

Escherichia coli cells normally require RNase E activity to form colonies (colony-forming ability [CFA]). The CFA-defective phenotype of cells lacking RNase E is partly reversed by overexpression of the related endoribonuclease RNase G or by mutation of the gene encoding the RNA helicase DeaD. We found that the carbon source utilization by rne deaD doubly mutant bacteria differs from that of rne(+) cells and from that of cells mutated in deaD alone and that the loss of rne function in these bacteria limits conversion of the glycolytic pathway product phosphoenolpyruvate to the tricarboxylic acid (TCA) cycle intermediate oxaloacetic acid. We show that the mechanism underlying this effect is reduced production of the enzyme phosphoenolpyruvate carboxylase (PPC) and that adventitious overexpression of PPC, which facilitates phosphoenolpyruvate utilization and connects the glycolytic pathway with the TCA cycle, restored CFA to rne deaD mutant bacteria cultured on carbon sources that otherwise were unable to sustain growth. We further show that bacteria producing full-length RNase E, which allows formation of degradosomes, have nutritional requirements different from those of cells supplied with only the N-terminal catalytic region of RNase E and that mitigation of RNase E deficiency by overexpression of a related RNase, RNase G, is also affected by carbon source. Our results reveal previously unsuspected effects of RNase E deficiency and degradosome formation on nutrient utilization by E. coli cells.
Synthesis of 99mTc-labeled Peptide p5+14 for Detection of Cardiac Amyloidosis - Preclinical Studies in a Mouse Model (2021)

3007 Introduction: Systemic amyloidosis is a rare but invariably fatal disorder resulting from the deposition of protein fibrils in organs and tissues which ultimately results in organ dysfunction. The major forms of amyloidosis, which account for more than 85% of the cases diagnosed in the US, result from the aggregation and deposition of monoclonal immunoglobulin light chains (AL amyloidosis) or, mutant or wild type, transthyretin (ATTR amyloidosis). The majority of patients with AL and ATTR present with cardiac amyloid deposits; however, due to the heterogeneous presentation of symptoms in these patients, a rapid and accurate diagnosis of disease is challenging. Peptide p5+14 is a pan-amyloid binding reagent that we have labeled with technetium-99m using a novel facile kit method for the specific detection of cardiac amyloid deposits. Methods: Peptide was labeled with a facile kit method. Peptide (100 μg) and 20 μg of stannous chloride were dried from a solution of dilute sodium hydroxide. The labeling was accomplished by addition of 1-2 mCi [99mTc] pertechnatate in 100 μL of saline. The radiolabeled peptide was purified by size-exclusion chromatography and the bioactivity assessed using a synthetic fibril pulldown assay. Mice with systemic inflammation-associated (AA) amyloidosis, notably in the liver and spleen, but with modest cardiac deposition received ~150 μCi of 99mTc-p5+14 or 99mTc-PyP, a bone seeking agent that has been shown to bind AA amyloid. SPECT/CT imaging was performed using an Inveon trimodality platform. Results: The 125I-p5+14 peptide was readily labeled using the kit method with a radiochemical yield of >90%. The purified product was >95% pure with a bioactivity of ~95% (binding to synthetic amyloid fibrils). Extracardiac amyloid uptake in the liver and spleen in AA mice resulted in 10% ID/g and 7% ID/g, respectively. SPECT/CT imaging of the excised heart revealed significantly higher uptake of 99mTc-p5+14 as compared to 99mTc-PyP. Conclusion: The production of 99mTc-labeled peptides for amyloid imaging has been previously described by our laboratory; however, we have now developed a facile kit-based method for generating a radiotracer that is optimally suited for the detection of cardiac amyloid deposits by SPECT imaging.Acknowledgements: Support for this work comes from the Amyloidosis and Cancer Theranostics Program gift fund.
Ventricular tachycardia as the first manifestation of disease (2017)

Ventricular tachycardia as the first manifestation of disease: an element with different clinical settings.
Training a Two Layer ReLU Network Analytically (2023)

Neural networks are usually trained with different variants of gradient descent based optimization algorithms such as stochastic gradient descent or the Adam optimizer. Recent theoretical work states that the critical points (where the gradient of the loss is zero) of two-layer ReLU networks with the square loss are not all local minima. However, in this work we will explore an algorithm for training two-layer neural networks with ReLU-like activation and the square loss that alternatively finds the critical points of the loss function analytically for one layer while keeping the other layer and the neuron activation pattern fixed. Experiments indicate that this simple algorithm can find deeper optima than Stochastic Gradient Descent or the Adam optimizer, obtaining significantly smaller training loss values on four out of the five real datasets evaluated. Moreover, the method is faster than the gradient descent methods and has virtually no tuning parameters.
Photoluminescence Study of Diffusion and Reactions of 18O-labeled Interstitial Oxygen Molecules in Amorphous SiO2 (2009)

A photoluminescence (PL) method to evaluate the concentration and isotopic fraction of 18O-labeled oxygen molecules (O2) dissolved in interstitial voids in amorphous SiO2 (a-SiO2) was developed. This method utilizes laser-induced infrared PL bands of interstitial O2 attributed to the transition from the first excited singlet state, in particular, the vibrational sideband coupled to the O-O stretching mode. From the variation of the concentration and isotopic fraction of interstitial O2 with time and temperature of thermal annealing under an 16O2 or 18O2 atmosphere, the diffusion of interstitial O2 as well as the rate of oxygen exchange between interstitial O2 and the Si-O network were examined directly and quantitatively. This observation provides clear experimental evidence that the main oxygen transport mechanism in a-SiO2 is the permeation of interstitial O2.
Extraction Method Affects Contents of Flavonoids and Carotenoids in Huanglongbing-Affected “Valencia” Orange Juice (2021)

A previous study using healthy "Valencia" orange fruit found that juicing extraction methods dramatically changed the orange juice (OJ) flavor and phytochemical profiles. The present study was conducted to confirm whether the same changes occur when Huanglongbing (HLB)-affected oranges were used. HLB has extensively spread to most OJ processing regions around the world, substantially deteriorating fruit and juice flavor quality and altering the phytochemical profiles. In this study, the effect of two major juice extractor types, a shear force extractor (SFE) and a reamer extractor (RE), on the juice quality and physiochemical profile was assessed using HLB-affected orange fruit. Juice extracted via SFE resulted in a lower yield with lower peel oil and higher pellet (peel tissue particles) content compared to juice obtained via RE. The SFE juice also had higher levels of hesperidin and other flavonoid glycosides, mainly due to plentiful peel tissue particles. The SFE juice was also abundant in carotenoids due to a large amount of flavedo particles in the juice. On the other hand, polymethoxylated flavones occurred at higher concentrations in the RE juice, and this may be due to the higher peel oil content in this juice. The SFE juice was rich in flavonoid glycosides and carotenoids, which are associated with potential antioxidant properties; however, the extra portion of the phytonutrients mostly existed in the pellets and possibly had low bioavailability. The results obtained from the HLB-affected oranges are in agreement with the previous observations of healthy oranges.
Progressive volume rendering of unstructured grids on modern GPUs (2006)

We have developed a new progressive technique that allows real-time volume rendering of large tetrahedral meshes. Our approach incrementally streams portions of the mesh to a hardware-assisted volume renderer and displays approximations that increase in quality until a full-quality rendering is achieved. The results of previous steps are stored as image data and re-used in each subsequent refinement, thus leading to an efficient rendering. Our interactive representation of the dataset is efficient, light-weight, and high quality. The result is a level-of-detail framework for interactive exploration of tetahedral datasets too large to render using conventional approaches.
Human Renal Cell Carcinoma Xenograft: Morphology, Growth and Chemosensitivities (1985)

A primary human renal clear cell carcinoma has been developed as a xenograft (JDF-1). Passage 7 of the JDF-1 tumor retained the microscopic morphology of the primary tumor, electron micrographs have confirmed its epithelial characteristics and karyotyping of a subsequent passage has proved it is not a murine hybrid. Immunoperoxidase studies using a panel of murine monoclonal antibodies demonstrate an antigenic phenotype specific for human renal cancer. In vitro chemosensitivities of the JDF-1 tumor were determined by the double-layer soft-agar clonogenic assay method. JDF-1 showed no significant sensitivities to several standard chemotherapeutic agents, but alpha-2-interferon and difluoromethylornithine in combination synergistically inhibited its growth by 74 per cent.
Optical characterization of two-dimensional photonic crystal cavities with indium arsenide quantum dot emitters (2001)

We have characterized the modes within two-dimensional photonic crystal nanocavities with self-organized indium arsenide quantum dots as an active material. Highly localized donor mode resonances with 3 to 5 nm linewidth were observed when spatially selective optical pumping the cavities. These modes could be lithographically tuned from 1100 to 1300 nm. Other, more extended modes, were also characterized and exhibited narrower resonance linewidths ranging from 0.6 to 2 nm.
Identifying and Developing Leadership Competencies in Health Research Organizations: A Pilot Study. (2012)

We investigated leadership competencies for developing senior and emerging leaders and the perceived effectiveness of leadership development programs in Health Research Organizations (HROs). A pilot study was conducted to interview HRO executives in Southern California. Respondents represented different organizational contexts to ensure a diverse overview of strategic issues, competencies, and development needs. We analyzed qualitative and quantitative data using an innovative framework for analyzing HRO leadership development. The National Center for Healthcare Leadership 'Health Leadership Competency Model' was used as the foundation of our competency research. Top strategic issues included economic downturn and external funding, the influence of governmental policies and regulations, operating in global markets, and forming strategic alliances. High priority NCHL leadership competencies required to successfully lead an HRO include talent development, collaboration, strategic orientation, and team leadership. Senior executives need financial skills and scientific achievement; emerging leaders need technical/scientific competence, information seeking, and a strong work ethic. About half of the respondents reported having no leadership development program (LDP). Almost all reported their organization encourages mentoring, but less than one-third reported an active formalized mentoring program. We conclude that uncertainties and challenges related to healthcare reform and the continued budget deficits will require HRO restructuring to contain costs, remove barriers to innovation, and show value-add in accelerating discovery to improve clinical care, patient outcomes, and community health. Successful leaders will need to become more strategic, entrepreneurial, and resourceful in developing research alliances, executing research operations, and continually improving performance at all levels of the HRO.
Temperature Measurement (2023)

This chapter presents the factual principles of thermoelectric circuits that equip the user to easily apply thermocouples for reliable and critical thermometry, even in unusual circumstances with justified confidence. The need for large thermocouple output has been drastically reduced by the enhanced sensitivity, stability, and noise suppression of modern solid-state digital thermocouple indicators. These instruments can routinely indicate temperature to 0.1°C resolution and stability for all letter-designated types. Some thermocouple indicators are hand-held and accommodate only a single thermocouple and only of a single type. A few provide dual thermocouple inputs and allow direct differential temperature measurement for which reference junction compensation must not be directly applied. Other bench-top units accommodate several thermocouple inputs of the same or of intermixed thermocouple and other sensor types.
Load Balancing Method between Storage Controllers by Considering Inhomogeneous Processing Load Characteristics and Performance Evaluation (2015)

We propose a technique called the central processing unit (CPU) Load Balancing method for Semi-Symmetric Active-Active dual controller storage systems to maintain load balancing between dual controllers by migrating logical unit (LU) ownerships from one controller to another, even if there are inhomogeneous operations between controllers. We develop a performance simulator and use it to evaluate the proposed method's operation. Our findings reveal that the proposed approach improves the average response time on continuous stable load by 2% and the system throughput by 18% compared to the conventional method. The CPU Load Balancing method is a better choice especially to achieve improvements in storage operability. In addition, our findings reveal that the proposed approach improves the average response time in simulated actual loads by 27% compared to the conventional method.
One-Selector One-Resistor Cross-Point Array With Threshold Switching Selector (2015)

This paper investigates the impact of threshold switching (TS) selector characteristics on the one-selector one-resistor (1S1R) cross-point array performance. TS selector parameter requirements are extracted for 1 Mb array, considering 1S, 1R cell compatibility, read/write margin, and power consumption constraints. The SPICE simulation results show that the threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) and the ON-state resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> ) are important selector parameters. Low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> eliminates 1R disturb issue during the read operation, but this comes at the expense of losing full cell nonlinearity (NL) during the write operation. Increase of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> and R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> improves the full cell NL and alleviate read disturb issue. However, these reduce 1S1R read window and additional voltages are required for both read and write operations. Compared with selector with nonabrupt current-voltage (I-V) characteristics, the TS selector is more favorable for the low-voltage operation. Finally, different reported TS selectors are evaluated, and the improvement directions are suggested.
Rapid symptom resolution with delayed-release Mesalamine 4.8g/d compared to 2.4g/d in moderately active Ulcerative Colitis patients with a history of more difficult to treat disease (2009)

To evaluate the time to resolution of the hallmark symptoms of ulcerative colitis (UC) (increased stool frequency [SF], rectal bleeding [RB]) in patients with moderately active UC with a history of more difficult to treat disease (i.e., patients previously treated with UC medical therapies). Data from 2 Phase III, multi-center, randomized, double-blind, 6-week activecontrol studies (ASCEND I and II) were combined and analyzed. Median time to resolution of the hallmark symptoms of UC with delayed-release mesa lamine 4.8 g/d (800 mg tab) was compared to 2.4g/d (400mg tab) in patients with moderately active UC (Physician's Global Assessment= 2) who had been previously treated with oral 5-ASAs, rectal therapies, steroids, or multiple medications. Time to resolution (score= 0) of UC symptoms was based on first day of resolution according to daily reports from patients via an interactive voice response system. Resolution of SF was defined as a patient's return to normal number of stools per day and resolution of RB was defined as the absence of visible blood in stool. A total of 423 analyzable patients had moderately active UC. Results of the median time to resolution analysis for the overall moderate population and according to previous UC medical therapies are shown in the table below. No Caption available. No Caption available. No Caption available. (Cont.) No Caption available. (Cont.) In general, the magnitude of the dose benefit (Hazard Ratio) for 4.8g/d vs 2.4g/d was greater in patients previously treated with UC medical therapies. Delayed- release mesalamine at a dose of 4.8g/d decreased the median time to resolution of the hallmark symptoms of UC compared to 2.4g/d in moderate UC patients with a history of more difficult to treat disease.
Al18F: A New Standard for Radiofluorination (2013)

TO THE EDITOR: 18F is the most common radionuclide used in PET imaging, but its application via a rapid, simple, easily accessible labeling procedure has been challenging. We congratulate Wan et al. for their recent article appearing online on April 3 and in the printed journal in May ([1][1]) on
The pentapeptide NKISK affects collagen fibril interactions in a vertebrate tissue (2000)

The pentapeptide NKISK has been reported to inhibit the binding of decorin, a proteoglycan on the surface of collagen fibrils, to fibronectin, a tissue adhesion molecule. Because of our interest in fibril-fibril binding as it relates to changes in length of ligament or tendon (during growth or contracture), we investigated the potential of this peptide to dissociate fibrils. The peptide permitted the release of intact fibrils into suspension for examination under the electron microscope (which has not previously been possible in mature vertebrate tissues).
Local Injection of Aminoglycosides for Prophylaxis Against Infection in Open Fractures (2015)

This study suggests that local aqueous aminoglycoside administration as an adjunct to systemic antibiotics may be effective in lowering infection rates in open fractures; further research with higher-level research designs are needed.
E1 mobile imaging: paradigm shift or technology bubble? (2005)

The idea of having a phone that can communicate visual information in addition to voice has been around for a long time. Since the late 1960s phone companies have tried repeatedly to develop and market landline based Picture Phones to consumers without any success. In late 1990's the first mobile phones with cameras were introduced in Japan. After their introduction, sales of mobile phone cameras grew quickly. By 2002 mobile phone cameras were being introduced throughout Asia, the US, and Europe. In 2003 almost 70 million mobile phone cameras were sold. It is expected that more than 150 million mobile phone cameras will be sold in 2004. Mobile phone cameras represent the largest and fastest growing market for solid-state image sensors in the world.
Alpha-fetoprotein in Abortion (1972)

The clinical value of maternal serum alpha-fetoprotein (AFP) as a guide to the outcome of threatened abortion was assessed. After the thirteenth week of gestation, abortion occurred more frequently (10/12) in women with abnormal serum AFP levels than in those (2/12) whose AFP concentrations were within the normal range. Low levels were present in women with blighted ovum and high concentrations were associated with intrauterine fetal death. In legal first and second trimester abortions, the circulating maternal AFP levels in postabortion samples were often higher than before abortion, irrespective of whether abortion was performed instrumentally or induced with prostaglandins. Maternal serum AFP levels provide a new means for prediction of the outcome of threatened abortion.
Regulation of stress-induced hematopoiesis (2015)

These exciting new findings will shape our fundamental understanding of how inflammatory signaling regulates hematopoiesis in health and disease, and facilitate the development of potential interventions to treat hematologic diseases associated with altered inflammatory signaling.