gebhart/patrepeval huggingface dataset:
Extracting the quark mixing phaseγfromB±→K±π+π−,B0→Ksπ+π−, andB¯0→Ksπ+π− (2007)

We discuss some aspects of the search for $CP$ asymmetry in the three body $B$ decays, revealed through the interference among neighbor resonances in the Dalitz plot. We propose a competitive method to extract the CKM $\ensuremath{\gamma}$ angle combining Dalitz plot amplitude analysis of ${B}^{\ifmmode\pm\else\textpm\fi{}}\ensuremath{\rightarrow}{K}^{\ifmmode\pm\else\textpm\fi{}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ and untagged ${B}^{0}$, ${\overline{B}}^{0}\ensuremath{\rightarrow}{K}_{s}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$. The method also obtains the ratio and phase difference between the tree and penguin contributions from ${B}^{0}$ and ${\overline{B}}^{0}\ensuremath{\rightarrow}{K}^{*\ifmmode\pm\else\textpm\fi{}}{\ensuremath{\pi}}^{\ensuremath{\mp}}$ decays and the $CP$ asymmetry between ${B}^{0}$ and ${\overline{B}}^{0}$. From Monte Carlo studies of 100 K events for the neutral mesons, we show the possibility of measuring $\ensuremath{\gamma}$.
The Importance of Water Transport in High Conductivity and High-Power Alkaline Fuel Cells (2019)

High ionic conductivity membranes can be used to minimize ohmic losses in electrochemical devices such as fuel cells, flow batteries, and electrolyzers. Very high hydroxide conductivity was achieved through the synthesis of a norbornene-based tetrablock copolymer with an ion-exchange capacity of 3.88 meq/g. The membranes were cast with a thin polymer reinforcement layer and lightly cross-linked with N,N,N',N'-tetramethyl-1,6-hexanediamine. The norbornene polymer had a hydroxide conductivity of 212 mS/cm at 80°C. Light cross-linking helped to control the water uptake and provide mechanical stability while balancing the bound (i.e. waters of hydration) vs. free water in the films. The films showed excellent chemical stability with <1.5% conductivity loss after soaking in 1 M NaOH for 1000 h at 80°C. The aged films were analyzed by FT-IR before and after aging to confirm their chemical stability. A H2/O2 alkaline polymer electrolyte fuel cell was fabricated and was able to achieve a peak power density of 3.5 W/cm2 with a maximum current density of 9.7 A/cm2 at 0.15 V at 80°C. The exceptionally high current and power densities were achieved by balancing and optimizing water removal and transport from the hydrogen negative electrode to the oxygen positive electrode. High water transport and thinness are critical aspects of the membrane in extending the power and current density of the cells to new record values.
Somatostatin Analogue Resistance in McCune-Albright Syndrome (2019)

McCune-Albright Syndrome (MAS) is a disorder characterized by involvement of multiple tissues, including skin, bone and endocrine glands. MAS is caused by post-zygotic mosaicism for GNAS gene mutations, which lead to a constitutively active form of the Gαs protein and increased cAMP levels. In the somatotropes of the pituitary, this increased cAMP leads to excessive growth hormone (GH) secretion. Somatostatin analogues (SSA), such as octreotide, that binds to somatostatin receptor SSTR2 are used in MAS patients to reduce GH secretion. However, MAS patients generally do not respond well to SSA, and GH control can rarely be achieved with SSA alone. In an in vitro model of MAS, five of the most common activating GNAS mutations lead to an increased level of cAMP, and a resistance to the treatment with SSA due to hyperactivated phosphokinase A. To further determine the underlying molecular causes of the SSA resistance, we studied the phosphorylation status of Filamin A (FLNA), a protein that couples somatostatin receptors to their cytoplasmic partners and to the cytoskeleton. Preliminary results suggest that three mutations of the GNAS gene may increase the phosphorylation status of FLNA.
Effect of metal proximity on remote electromagnetic detection of molten metal level in pyrometallurgical furnaces (2019)

The production of metals such as nickel, copper, and platinum group metals (PGMs) is typically done by smelting concentrated ores in pyrometallurgical furnaces. The process of smelting involves generating high temperatures by arcing or chemical reactions and separating the concentrate into the product, being molten metal or matte and the waste, being slag. The density of the metal is generally higher than that of slag and therefore, slag tends to float on top of the metal. It is desirable to determine the position of the metal and slag interface to maximize production efficiency. Reliable and continuous level measurements are desired by smelting operators to determine when to commence tapping (removal of molten metal from the furnace) and monitor the tapping operation. In addition, metal level control is important for the long-term structural integrity of the furnace. Today, common methods of estimating metal level in furnaces include mass and energy balance calculations and sounding bar measurements from above the furnace.To overcome the shortcomings of the current methods, and to improve the utility and accuracy of metal/slag level measurement, a continuous sensing, eddy current based system, embedded in the furnace sidewall, is being studied. The eddy current drive and pickup coil sensor system developed in this study was able to measure the signal in a laboratory setting at a liftoff distance of 305 mm from the simulated metal/slag interface. However, while the electromagnetic fields pass easily through refractory brick, they may be affected by the presence of conducting material in the vicinity of the probe. The effect of such material, such as copper cooling plates in an actual furnace, on the signal response was examined. It was observed that the cooling plate next to the coil configuration increased the signal by 28 % whereas, when the copper plate was placed behind the coils, the signal was reduced by 74 %. The purpose of this paper is to describe prior art in the field of metal level measurement in pyrometallurgical furnaces, outline the developed eddy current based system and to present the experimental results of laboratory testing.
Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination (2012)

To evaluate the relevance of directing antigen-specific CD4(+) T helper cells as part of effective anticancer immunotherapy, we investigated the immunologic and clinical responses to vaccination with dendritic cells (DC) pulsed with either MHC class I (MHC-I)-restricted epitopes alone or both MHC class I and II (MHC-I/II)-restricted epitopes. We enrolled 33 stage III and IV HLA-A*02:01-positive patients with melanoma in this study, of whom 29 were evaluable for immunologic response. Patients received intranodal vaccinations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-restricted tumor-associated antigens (TAA) of tyrosinase and gp100, depending on their HLA-DR4 status. In 4 of 15 patients vaccinated with MHC-I/II-loaded DCs and 1 of 14 patients vaccinated with MHC-I-loaded DCs, we detected TAA-specific CD8(+) T cells with maintained IFN-γ production in skin test infiltrating lymphocyte (SKIL) cultures and circulating TAA-specific CD8(+) T cells. If TAA-specific CD4(+) T-cell responses were detected in SKIL cultures, it coincided with TAA-specific CD8(+) T-cell responses. In 3 of 13 patients tested, we detected TAA-specific CD4(+)CD25(+)FoxP3(-) T cells with high proliferative capacity and IFN-γ production, indicating that these were not regulatory T cells. Vaccination with MHC-I/II-loaded DCs resulted in improved clinical outcome compared with matched control patients treated with dacarbazine (DTIC), median overall survival of 15.0 versus 8.3 months (P = 0.089), and median progression-free survival of 5.0 versus 2.8 months (P = 0.0089). In conclusion, coactivating TAA-specific CD4(+) T-helper cells with DCs pulsed with both MHC class I and II-restricted epitopes augments TAA-specific CD8(+) T-cell responses, contributing to improved clinical responses.
Low Energy Ion Scattering Investigations of n-Butanol−Ice System in the Temperature Range of 110−150 K (2009)

We have investigated the interaction of n-butanol (NBA) with thin layers of water ice prepared in ultra high vacuum in the temperature range of 110−150 K. From the mass spectra of the chemically sputtered species, created upon the collision of low energy (≥30 eV) Ar+ ions, we study the process of diffusive mixing of NBA with water ice, at the molecular level. The results show that NBA undergoes diffusive mixing with H2O. Even after depositing 1000 monolayers (MLs) of amorphous solid water (ASW) over NBA, both the species are observed on the surface. However, when NBA is deposited over ASW, no water is seen on the surface above 3−5 MLs of NBA. This could be interpreted as the absence of diffusive mixing in this system or surface segregation of NBA, in view of its lower surface energy just as in the case of liquid alcohols. An isomeric alcohol, namely, tert-butyl alcohol (TBA), also behaves similarly. Although the presence of NBA and TBA is detected, in the presence of ASW, they undergo selective ionization, giving specific peaks in the mass spectrum. D2O behaves in a manner similar to that of H2O. Preliminary experiments with other alcohols; namely, methanol, ethanol, and propanol were also done, and the results suggest that incomplete diffusion or surface segregation begins with propanol.
Supp Table 2 from Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia (2023)

&lt;p&gt;MDS Patient Characteristics&lt;/p&gt;
Outcome measures, pooled index and quality of life instruments in rheumatoid arthritis (1996)

We conclude that randomized clinical trials of treatments in RA should now ideally use the core set of clinical endpoints and validated QoL instruments for assessing safety and efficacy.
Estimation of trunk extracellular volume by bioimpedance (2002)

Bioimpedance analysis (BIA) of the trunk using spot electrodes yields extracellular volume (ECV) that is spuriously low. This discrepancy has been attributed to the small ratio of trunk length to trunk surface area. If current is injected into the trunk through the limbs such as with whole body BIA the electric field in the trunk is inhomogeneous and extracellular resistance (R) between equidistant and sagittal electrodes decreases with increasing distance (d) from the point of current injection. The relationship between R measured between electrodes arranged in a rectangular array on the trunk surface and d was measured in 3 subjects. The dependency of R on d was modeled by the power relation R=ad/sup -b/. An equation was developed to calculate trunk ECV and to correct for inhomogeneous resistance measured on the trunk surface. The equation is based on the assumption of an equivalent volume segment with a homogeneous electric field. The cross-sectional area of this equivalent volume segment was determined to be one fourth of the cross-sectional area of the trunk. Thus, a factor (k) of four has to be used to calculate ECV from R measured by two spot electrodes placed in a sagittal plane close to the point of current injection.
ChemInform Abstract: A NEW ROUTE TO 2,4‐DIBENZYLTETRAHYDROQUINOLINE. REVERSIBILITY OF THE HOMOLYTIC AROMATIC BENZYLATION (1979)

Abstract Phenylessigsäure (I) kann durch Reaktion mit Natriumpersulfat/Ti(III) oder /Ag(I) zu Benzylradikalen (II) oxidiert werden, die mit Chinolin (III) umgesetzt werden.
Client cache management in a distributed object database (1995)

A distributed object database stores objects persistently at servers. Applications run on client machines, fetching objects into a client-side cache of objects. If fetching and cache management are done in terms of objects, rather than fixed-size units such as pages, three problems must be solved: 1. which objects to prefetch, 2. how to translate, or swizzle, inter-object references when they are fetched from server to client, and 3. which objects to displace from the cache. This thesis reports the results of experiments to test various solutions to these problems. The experiments use the runtime system of the Thor distributed object database and benchmarks adapted from the Wisconsin 007 benchmark suite. The thesis establishes the following points: 1. For plausible workloads involving some amount of object fetching, the prefetching policy is likely to have more impact on performance than swizzling policy or cache management policy. 2. A simple breadth-first prefetcher can have performance that is at worst roughly comparable
Metabolic and histological features of non‐alcoholic fatty liver disease patients with different serum alanine aminotransferase levels (2008)

Metabolic factors, but not ALT, are associated with histological severity. Patients with ALT < 0.5 x ULN may still have non-alcoholic steatohepatitis (NASH) and significant fibrosis. Evaluation of NAFLD patients should be based on metabolic risk factors, but not ALT level.
Reactions of monatomic and diatomic manganese with carbon monoxide. Matrix infrared spectroscopic evidence for pentacarbonylmanganese Mn(CO)5 and the binuclear carbonyls Mn2(CO)n (where n = 1 or 2) (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of monatomic and diatomic manganese with carbon monoxide. Matrix infrared spectroscopic evidence for pentacarbonylmanganese Mn(CO)5 and the binuclear carbonyls Mn2(CO)n (where n = 1 or 2)H. Huber, E. P. Kundig, G. A. Ozin, and A. J. PoeCite this: J. Am. Chem. Soc. 1975, 97, 2, 308–314Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/ja00835a014https://doi.org/10.1021/ja00835a014research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tapping Mode Atomic Force Microscopy on Polymers:  Where Is the True Sample Surface? (2001)

We investigate in detail the processes involved when soft polymeric materials are imaged with TappingMode atomic force microscopy (TM-AFM). Measuring lateral arrays of amplitude/phase vs distance (APD) curves, we are able to determine quantitatively the amount of tip indentation and reconstruct the shape of the “real” surface of the sample. Moreover, contrast inversion in height and TappingMode phase images is explained on the basis of attractive and repulsive contributions to the tip−sample interaction. The experiments are performed on surfaces of poly(styrene-block-butadiene-block-styrene) (SBS) triblock copolymers acting as a model system.
Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient (2016)

Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find alternative safe antiplatelet inhibitors for the vulnerable population who has hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow<sup>®</sup>), which significantly inhibited platelet aggregation. Human volunteer studies demonstrated the potency and bioavailability of active compounds in Fruitflow<sup>®</sup>. Fruitflow<sup>®</sup> became the first product in Europe to obtain an approved, proprietary health claim under Article 13(5) of the European Health Claims Regulation 1924/2006 on nutrition and health claims made on foods. Fruitflow<sup>®</sup> is now commercially available in different countries worldwide. In addition to its reduction in platelet reactivity, Fruitflow<sup>®</sup> contains anti-angiotensin-converting enzyme and anti-inflammatory factors, making it an effective and natural cardio-protective functional food.
Prevention of cancer therapy-related heart failure, is it really possible? (2020)

Cuomo, Alessandra; Pirozzi, Flora; Abete, Pasquale; Tocchetti, Carlo Gabriele; Mercurio, ValentinaAuthor Information
Summary of Working Group 8: Advanced Laser and Beam Technology and Facilities (2018)

This paper summarizes the trends in laser technology and facilities for advanced accelerator research as presented at the Advanced Accelerator Concepts Workshop held in Breckenridge, CO between August 12 and August 17, 2018. A synopsis of how contributions presented at the conference fit within these trends is provided. Readers may then refer to the full references for additional detail.
Data from Enhanced targeting with heterobivalent ligands (2023)

&lt;div&gt;Abstract&lt;p&gt;A novel approach to specifically target tumor cells for detection and treatment is the proposed use of &lt;i&gt;hetero&lt;/i&gt;multivalent ligands, which are designed to interact with, and noncovalently crosslink, multiple different cell surface receptors. Although enhanced binding has been shown for synthetic &lt;i&gt;homo&lt;/i&gt;multivalent ligands, proof of cross-linking requires the use of ligands with two or more different binding moieties. As proof-of-concept, we have examined the binding of synthetic heterobivalent ligands to cell lines that were engineered to coexpress two different G-protein-coupled human receptors, i.e., the human melanocortin 4 receptor (MC4R) expressed in combination with either the human δ-opioid receptor (δOR) or the human cholecystokinin-2 receptor (CCK2R). Expression levels of these receptors were characterized by time-resolved fluorescence saturation binding assays using Europium-labeled ligands; Eu-DPLCE, Eu-NDP-α-MSH, and Eu-CCK8 for the δOR, MC4R, and CCK2R, respectively. Heterobivalent ligands were synthesized to contain a MC4R agonist connected via chemical linkers to either a δOR or a CCK2R agonist. In both cell systems, the heterobivalent constructs bound with much higher affinity to cells expressing both receptors, compared with cells with single receptors or to cells where one of the receptors was competitively blocked. These results indicate that synthetic heterobivalent ligands can noncovalently crosslink two unrelated cell surface receptors, making feasible the targeting of receptor combinations. The &lt;i&gt;in vitro&lt;/i&gt; cell models described herein will lead to the development of multivalent ligands for target combinations identified in human cancers. [Mol Cancer Ther 2009;8(8):2356–65]&lt;/p&gt;&lt;/div&gt;
Conducting electron-beam resists based on polyaniline (1998)

Conducting resists have a number of potential applications in microlithography (1). For example, during electron beam (e-beam) exposure of insulating materials, pat tern distortions and displacements are observed due to charging ofthe surface. In addition, charging results in alignment errors from one level oflithography to another. Charging is also a problem in SEM metrology ofmasks or resists. Conducting polymers have been shown to function as effective discharge layers when applied as coatings either above or below the imaging resist or on the surface ofa mask (1-3). Resists have also been developed based on conducting polymers (1,3-5). However, the overall lithographic perform ance ofthese systems has not been competitive with conventional resists. Polyaniline has been one ofthe preferred conducting polymers for these applications because it combines high solubility, ease of synthesis, and a great deal of chemical versatility. Previously, we reported on a new family ofwater based polyaniline denvatives which form excellent dissipative coatings. We also reported on conducting resists based on these systems (3). In this paper, we report on a new negative tone resist, PAM WM. This is based on functionalization of a hydroxysubstituted polyaniline with methacrylate side groups.
Effect of Salt Spray Cyclic Corrosion on the Mechanical and Reversibility Performance of Mixed Material Joints With Modified Adhesive (2022)

Abstract The effect of cyclic corrosion on the static strength performance and reversibility performance of multi-material single lap joints is investigated. Aluminum substrates are adhesively bonded to Carbon-Fiber-Reinforced thermoplastic composite substrates using a commercially available two-part epoxy. The adhesive is modified with Thermally Expandable Particles at various concentrations by weight, with the purpose of allowing for joint separation using a charged RF coil to evaluate reversibility performance. The quasi-static performance of baseline joints is assessed, and the results from the various particle concentrations are compared. The cyclic corrosion testing of the Single Lap Joints is performed in accordance with a GMW 14872 3 stage laboratory standard for different lengths of duration up to 57 cycles. Quasi-static lap shear tests are performed at various stages of corrosion cycling and compared. Results and conclusions are provided.
Passive optical networks based on OFDM: Perspectives and experimental verifications (2013)

Investigate the different requirements for OFDMA-PON in downstream and upstream direction. We show an approach to reduce the DSP effort at the ONUs and demonstrate the OFDMA upstream transmission with four individually modulated ONUs with central distribution of the optical carrier and coherent reception at the OLT.
DC resistivity at the Ahuachapan geothermal field, El Salvador (1988)

Deep dc resistivity surveying has been performed at the Ahuachapan Geothermal Field in western El Salvador. The field lies on the north base if the volcanic range that runs the length of the country and is the site of a significant active geothermal powerplant. The technical purpose of the surveying was to assess the geophysical properties of the geothermal regime around the existing field. The survey was carried out as a colinear dipole-dipole survey using dipole spacings of 500m and 1000m, and dipole separations of up to fourteen dipole lengths. Results included (1) the observation that the geothermal reservoir was not readily detectable due to surface lithologic changes and extensive cultural effects, (2) the hydrothermally altered areas are readily recognized by their low resistivities, (3) local lithologies appear to be mappable based on their in situ resistivities, (4) the greater field logistical convenience of the shorter 500m dipole spacings is negated by the increase in topographic effects, and (5) if appropriate dipole separations are used, there is no need to run surveys of both 500 and 1000 meter dipole spacings to gather shallow and deep information. 7 figs.