gebhart/patrepeval huggingface dataset:
Abstract B84: Decipher the role of IL-33 as an activator of NK cells’ antitumor activity (2020)

Abstract Interleukin (IL)-33 is an alarmin belonging to the IL-1 family. Through its receptor ST2, IL-33 promotes both type 1 and type 2 immune responses, depending on the type of responding cells and the microenvironment in damaged tissues. Consistently, paradoxical roles of IL-33 have been reported in the context of cancer. These observations prompted us to investigate i) the expression of IL-33/ST2 in breast tumors and ii) the role of IL-33/ST2 in NK cell activation in physiologic and tumor contexts. Using immunohistochemistry (IHC) and transcriptomic analyses, we observed that IL-33 is expressed at higher levels in ductal carcinoma in situ (DCIS) compared to invasive breast cancer (IBC), especially in the stroma and in luminal BC subtype. In situ, IL-33 was mainly detected in endothelial cells and at lower extent in scattered cells within the stroma of breast tumors. Furthermore, we unraveled a new pathway for NK cells’ activation where IL-12 upregulates ST2 on human NK cells, which in turn become responsive to IL-33 by secreting high levels of IFN-γ and increasing their cytotoxic activity. This effect was specific to a subset of human CD56dim NK cells (20%) and was dependent on STAT-4 phosphorylation. In mice, we also observed a strong activation of spleen NK cell by IL-33 in combination with IL-12 in vitro. Finally, using IL-33ko mice, preliminary results show a contribution of endogenous IL-33 in the prevention of experimental lung metastasis development following B16 iv injection in therapeutic settings using exogenous administration of IL-12. Following up on these results, our aim is now to i) better characterize IL-33-responsive NK cells subpopulation in blood, ii) understand why human CD56bright NK cells do not upregulate ST2 despite response to IL-12 by phosphorylating STAT-4, iii) characterize NK cells’ response to IL-33 in human breast tumors, iv) evaluate ST2 expression by immune cells infiltrating breast and ovarian tumors, and v) confirm the activating role of IL-33 on NK cells’ biology in tumor models in vivo. All together, our observations are in favor of an NK-mediated antitumor role of IL-33 that we are currently pursuing as a potential novel therapeutic strategy in cancer. Citation Format: Anais Eberhardt, Elena Blanc, Emilie Lardenois, Sarah Renaudineau, Jennifer Herbulot, Benoit Dumont, Isabelle Durand, Emilie Charrier, Pauline Schmitt, Jean-Philippe Girard, Antoine Marçais, Thierry Walzer, Christophe Caux, Nathalie Bendriss-Vermare. Decipher the role of IL-33 as an activator of NK cells’ antitumor activity [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2018 Nov 27-30; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(4 Suppl):Abstract nr B84.
The Expression of C-Jun and Junb mRNA in Renal Cell Cancer and in Vitro Regulation by Transforming Growth Factor Beta 1 and Tumor Necrosis Factor Alpha 1 (1992)

The proto-oncogene C-jun acts as a transcriptional activator or repressor for numerous cellular genes, and the overexpression of these genes may cause malignant transformation. JunB inhibits c-jun's transforming activities. We investigated the expression of jun genes in renal cell cancer (RCC) and their regulation by cytokines and transforming growth factor beta 1 (TGF-b1). The constitutive expression of c-jun was detected in 39 of 43 fresh frozen RCC, 5 of 10 normal kidneys, and the expression of junB detected in 28 of 34 RCC, 5 of 6 normal kidneys. C-jun was also found expressed in all 10 RCC tumor lines examined and junB was expressed at low levels in 6 of 10 renal tumor lines. TGF-b1 and tumor necrosis factor alpha (TNF-a) have been shown to alter the expression of jun genes in other tissue types. Additionally, TGF-b1, TNF-a, and gamma interferon (g-IFN) were shown to inhibit the growth of RCC. We found that TGF-b1 highly augmented the expression of junB (mean of 34 folds, p less than .05), but did not significantly alter the expression of c-jun, the transforming gene. In contrast, TNF-a significantly enhanced the expression of both c-jun (mean fold enhancement of 2.1, p less than .05) and junB (2.2 folds, p less than .05). Interleukin-2 (IL-2), interleukin-4 (IL-4) and g-IFN did not significantly alter jun expression. The findings presented suggest that c-jun may have a role in inducing malignant transformation in RCC and a novel mechanism by which TGF-b1 may exert its anti-tumor effects, via the activation of junB. Additionally, although TGF-b1, TNF-a, and g-IFN all have anti-proliferative actions on RCC in vitro, they were found to have different effects in altering jun expressions.
Sunlight, keratotic skin lesions and skin cancer in renal transplant recipients (1993)

In a retrospective follow-up study, 36 renal transplant recipients with, and 101 without, skin cancer, who had received their first transplant before January 1981 and who were still alive with a functioning graft on 1 August 1989, were assessed to determine the risk of non-melanoma skin cancer in relation to exposure to sunlight during childhood and adolescence. The contribution of the number of keratotic skin lesions to the skin cancer risk was also assessed. The estimated relative risks (odds ratios) of skin cancer in relation to exposure to sunlight and the presence of keratotic skin lesions were calculated by maximum likelihood estimation in a logistic model. The majority of skin cancers and keratotic skin lesions were confined to sun-exposed skin. After adjustment for possible confounding variables, the odds ratios of skin cancer for moderate and high cumulative life-time exposure to sunlight, respectively, compared with low exposure, were 2.4 (95% confidence interval [CI] 0.64-9.3) and 47.6 (95% CI 5.4-418). Exposure to sunlight before the age of 30 contributed more to the risk of developing skin cancer later in life than exposure after the age of 30. No association was found between cumulative life-time exposure to sunlight and the number of keratotic skin lesions. Nevertheless, these lesions behaved as a strong independent risk factor in the development of skin cancer. The adjusted odds ratio of skin cancer for 50-99 lesions compared with < 50 lesions was 4.5 (95% CI 1.1-18.2); the adjusted odds ratio for > or = 100 lesions compared with < 50 lesions was 20.8 (95% CI 5.3-81.7).(ABSTRACT TRUNCATED AT 250 WORDS)
Superconductivity-Induced Anomalies in the Spin Excitation Spectra of Underdoped YBa2Cu3O6+x (1997)

Polarized and unpolarized neutron scattering have been used to determine the effect of superconductivity on the magnetic excitation spectra of YB${\mathrm{a}}_{2}$C${\mathrm{u}}_{3}$${\mathrm{O}}_{6.5}$ $({T}_{c}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}52\phantom{\rule{0ex}{0ex}}\mathrm{K})$ and YB${\mathrm{a}}_{2}$C${\mathrm{u}}_{3}$${\mathrm{O}}_{6.7}$ $({T}_{c}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}67\phantom{\rule{0ex}{0ex}}\mathrm{K})$. Pronounced enhancements of the spectral weight centered around 25 and 33 meV, respectively, are observed below ${T}_{c}$ in both crystals, compensated predominantly by a loss of spectral weight at higher energies. The data provide important clues to the origin of the 40 meV magnetic resonance peak in YB${\mathrm{a}}_{2}$C${\mathrm{u}}_{3}$${\mathrm{O}}_{7}$.
Sleep and waste clearance: The association of sleep quality with a 7T IVIM imaging derived proxy of interstitial fluid (2023)

Cerebral clearance is most active during sleep, therefore reduced sleep quality might induce impaired clearance function. Interstitial fluid (ISF) washes waste products from in-between cells through the parenchyma and its volume is found to be regulated by the sleep-wake cycle. Assessment of the ISF-fraction through IVIM can be a potential, non-invasive method to determine sleep-related variations in ISF, without contamination of parenchymal or microvascular diffusion. The current exploratory study investigates the potential of the IVIM-derived ISF-fraction to assess ISF-volume changes in relation to sleep by examining whether these changes are driven by actual hours of sleep or self-reported sleep quality.
Graded Dielectric Thin Films Prepared by Chemical Solution Deposition (1999)

Columnar structured dielectric (Ba 1-x Sr x )TiO 3 thin films with gradients in composition normal to the growth surface were grown on platinum coated silicon substrates by a chemical solution deposition (CSD) method. The composition gradients were studied by X-ray diffraction analysis and Rutherford backscattering spectrometry, and the film morphology was analyzed by scanning electron microscopy. In the graded thin films the diameter of the grain columns as well as the preferred grain orientation can be tailored by the sequence of the layers. The dielectric properties were analyzed as a function of the composition gradiant and the temperature. The temperature dependence of the capacitance of the graded films, which were contacted in a plate capacitor setup can be simulated by a network of (Ba 1-x Sr x )TiO 3 thin film capacitors in series.
Indigenous companion planting in the great churn: Three sisters in Kalapuya ilihi (2022)

This article addresses place, culture, community, and mobility in relation to Indigenous food sovereignty and TEK (traditional ecological knowledge). We start with a reflection on what it means to live in the Pacific Northwest of the United States for people from tribes that use Three Sisters agriculture. Two of the authors grew corn, beans, and squash using wintertime, indoor hydroponics and other methods in a performance art mode in Kalapuya ilihi (Western Oregon, USA). Growing these sacred companion plants out of soil, out of sun, out of season, and out of place served as a meditation on our own senses of dislocation and disjuncture as well as modes of connection as Southeastern Natives living in the Pacific Northwest. The politics and practice of growing and/or tending traditional Indigenous food plants in both traditional and non-traditional ways and places provided new language for understanding Indigenous cultural and social health in relation to Indigenous traditions, mobility, and relationality. The three authors (two from Southeastern tribes, one from a Northwestern tribe) provide a model for collaborative intercultural Indigenous ecological projects as a mode of learning, a mode of relational Indigenous mobility, a mode of community-building, and a mode of engaging in Indigenous food sovereignty. Working on community and educational projects together helped us understand companion planting as an analogy, an aesthetic, a method, and a mode for building relational futures.
Monolithic Three-Section Injection-Locked Laser for Optical Oversampled Analog-to-Digital Conversion (2015)

A novel linear interferometric intensity modulator is demonstrated with an extremely low Vπ of 1.1 mV and a SFDR of 75 dB.Hz2/3. This is achieved by modulating the passive section of the injection-locked mode-locked laser.
Mapping method for dynamically reconfigurable architecture (2009)

We present a mapping algorithm for our dynamically reconfigurable architecture suitable for stream applications such as H.264. Because our target architecture consists heterogeneously of four different configuration format units, it's difficult to apply the conventional algorithms. We propose a heuristic mapping algorithm enabling the mapping of generic dataflow graph onto this complex hardware automatically. We mapped five main functions of H.264 decoder onto our architecture and compared the results with those of manual mapping performed by an experienced engineer. The results show optimization of three of the five functions is equal to that in the case of the manual mapping.
Toward humanoid robots for operations in complex urban environments (2010)

Many infantry operations in urban environments, such as building clearing, are extremely dangerous and difficult and often result in high casualty rates. Despite the fast pace of technological progress in many other areas, the tactics and technology deployed for many of these dangerous urban operation have not changed much in the last 50 years. While robots have been extremely useful for improvised explosive device (IED) detonation, under-vehicle inspection, surveillance, and cave exploration, there is still no fieldable robot that can operate effectively in cluttered streets and inside buildings. Developing a fieldable robot that can maneuver in complex urban environments is challenging due to narrow corridors, stairs, rubble, doors and cluttered doorways, and other obstacles. Typical wheeled and tracked robots have trouble getting through most of these obstacles. A bipedal humanoid is ideally shaped for many of these obstacles because its legs are long and skinny. Therefore it has the potential to step over large barriers, gaps, rocks, and steps, yet squeeze through narrow passageways, and through narrow doorways. By being able to walk with one foot directly in front of the other, humanoids also have the potential to walk over narrow "balance beam" style objects and can cross a narrow row of stepping stones. We describe some recent advances in humanoid robots, particularly recovery from disturbances, such as pushes and walking over rough terrain. Our disturbance recovery algorithms are based on the concept of Capture Points. An N-Step Capture Point is a point on the ground in which a legged robot can step to in order to stop in N steps. The N-Step Capture Region is the set of all N-Step Capture Points. In order to walk without falling, a legged robot must step somewhere in the intersection between an N-Step Capture Region and the available footholds on the ground. We present results of push recovery using Capture Points on our humanoid robot M2V2.
Maintenance of muscle mass in adult male mice is independent of testosterone (2021)

Testosterone is considered a potent anabolic agent in skeletal muscle with a well-established role in adolescent growth and development in males. However, the role of testosterone in the regulation of skeletal muscle mass and function throughout the lifespan has yet to be fully established. While some studies suggest that testosterone is important for the maintenance of skeletal muscle mass, an understanding of the role this hormone plays in young, adult, and old males with normal and low serum testosterone levels is lacking. We investigated the role testosterone plays in the maintenance of muscle mass by examining the effect of orchiectomy-induced testosterone depletion in C57Bl6 male mice at ages ranging from early postnatal through old age (1.5-, 5-, 12-, and 24-month old mice). Following 28 days of testosterone depletion, we assessed mass and fiber cross-sectional-area (CSA) of the tibialis anterior, gastrocnemius, and quadriceps muscles. In addition, we measured global rates of protein synthesis and degradation using the SuNSET method, western blots, and enzyme activity assays. Twenty-eight days of testosterone depletion resulted in reduced muscle mass in the two youngest cohorts, but had no effect in the two oldest cohorts. Mean CSA decreased only in the youngest cohort and only in the tibialis anterior muscle. Testosterone depletion resulted in a general increase in proteasome activity at all ages. No change in protein synthesis was detected at the terminal time point. These data suggest that within physiological serum concentrations, testosterone may not be critical for the maintenance of muscle mass in mature male mice; however, in young mice testosterone is crucial for normal growth.
Starlike Block Copolymers with Amphiphilic Arms as Models for Unimolecular Micelles (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStarlike Block Copolymers with Amphiphilic Arms as Models for Unimolecular MicellesAndreas Heise, James L. Hedrick, Curtis W. Frank, and Robert D. MillerView Author Information IBM Research Center, 650 Harry Road San Jose, California 95120 Department of Chemical Engineering Stanford University, Stanford, California 95305 Cite this: J. Am. Chem. Soc. 1999, 121, 37, 8647–8648Publication Date (Web):September 1, 1999Publication History Received29 December 1998Published online1 September 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ja984456ghttps://doi.org/10.1021/ja984456grapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1385Altmetric-Citations184LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Micelles,Organic compounds,Polymers,Solvents Get e-Alerts
X-Ray Laser Microscopy of Rat Sperm Nuclei (1992)

The development of high brightness and short pulse width (< 200 picoseconds) x-ray lasers now offers biologists the possibility of high-resolution imaging of specimens in an aqueous environment without the blurring effects associated with natural motions and chemical erosion. As a step toward developing the capabilities of this type of x-ray microscopy, a tantalum x-ray laser at 44.83 angstrom wavelength was used together with an x-ray zone plate lens to image both unlabeled and selectively gold-labeled dried rat sperm nuclei. The observed images show approximately 500 angstrom features, illustrate the importance of x-ray microscopy in determining chemical composition, and provide information about the uniformity of sperm chromatin organization and the extent of sperm chromatin hydration.
Formation of the 1,3‐Oxazepine ring system during the oxidation of an alcohol with activated dimethyl sulfoxide (1995)

Abstract Alcohol 3 , an intermediate in indole alkaloid synthesis, was converted to the ox‐azepinoindoloquinolizine 5 by oxidation with DMSO activated by the sulfur trioxide/pyridine complex. The ring closure proceeds through the common oxidation side‐product, methylthiomethyl ether 4.
Local influence of calcifications on the wall mechanics of abdominal aortic aneurysm (2006)

Finite element wall stress simulations on patient-specific models of abdominal aortic aneurysm (AAA) may provide a better rupture risk predictor than the currently used maximum transverse diameter. Calcifications in the wall of AAA lead to a higher maximum wall stress and thus may lead to an elevated rupture risk. The reported material properties for calcifications and the material properties actually used for simulations show great variation. Previous studies have focused on simplified modelling of the calcification shapes within a realistic aneurysm shape. In this study we use an accurate representation of the calcification geometry and a simplified model for the AAA. The objective of this approach is to investigate the influence of the calcification geometry, the material properties and the modelling approach for the computed peak wall stress. For four realistic calcification shapes from standard clinical CT images of AAA, we performed simulations with three distinct modelling approaches, at five distinct elasticity settings. The results show how peak wall stress is sensitive to the material properties of the calcifications. For relatively elastic calcifications, the results from the different modelling approaches agree. Also, for relatively elastic calcifications the computed wall stress in the tissue surrounding the calcifications shows to be insensitive to the exact calcification geometry. For stiffer calcifications the different modelling approaches and the different geometries lead to significantly different results. We conclude that an important challenge for future research is accurately estimating the material properties and the rupture potential of the AAA wall including calcifications.
Maggot therapy: a review of the therapeutic applications of fly larvae in human medicine, especially for treating osteomyelitis (1988)

In traditional medical practice, the larvae of some Diptera: Calliphoridae, notably Lucilia illustris (Meigen), L.sericata (Meigen) and Phormia regina (Meigen), have been employed for maggot therapy, i.e. to help clean lesions antiseptically, especially for treatment of chronic osteomyelitis. This mode of treatment remains appropriate for cases where antibiotics are ineffective and surgery impracticable.
Separation of silver from other metal cations using pyridone and triazole macrocycles in liquid membrane systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of silver from other metal cations using pyridone and triazole macrocycles in liquid membrane systemsR. M. Izatt, G. C. Lindh, R. L. Bruening, Peter. Huszthy, C. W. McDaniel, J. S. Bradshaw, and J. J. ChristensenCite this: Anal. Chem. 1988, 60, 17, 1694–1699Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ac00168a013https://doi.org/10.1021/ac00168a013research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computation of mutual fitness by competing bacteria (2008)

Competing populations in shared spaces with nonrenewable resources do not necessarily wage a battle for dominance at the cost of extinction of the less-fit strain if there are fitness advantages to the presence of the other strain. We report on the use of nanofabricated habitat landscapes to study the population dynamics of competing wild type and a growth advantage in stationary phase (GASP) mutant strains of Escherichia coli in a sealed and heterogeneous nutrient environment. Although GASP mutants are competitors with wild-type bacteria, we find that the 2 strains cooperate to maximize fitness (long-term total productivity) via spatial segregation: despite their very close genomic kinship, wild-type populations associate with wild-type populations and GASP populations with GASP populations. Thus, wild-type and GASP strains avoid each other locally, yet fitness is enhanced for both strains globally. This computation of fitness enhancement emerges from the local interaction among cells but maximizes global densities. At present we do not understand how fluctuations in both spatial and temporal dimensions lead to the emergent computation and how multilevel aggregates produce this collective adaptation.