gebhart/patrepeval huggingface dataset:
Pure hydrocarbon sorption properties of poly(1-trimethylsilyl-1-propyne) (PTMSP), poly(1-phenyl-1-propyne) (PPP), and PTMSP/PPP blends (1996)

Propane and n-butane sorption in blends of poly(1-trimethylsilyl-1-propyne) (PTMSP) and poly(1-phenyl-1-propyne) (PPP) have been determined. Solubilities of propane and n-butane increased as the PTMSP content in the blends increased. This result is consistent with the higher free volume of PTMSP-rich blends and the better thermodynamic compatibility between PTMSP and these hydrocarbons. Propane and n-butane sorption isotherms were well described by the dual-mode model for sorption in glassy polymers. PTMSP/PPP blends are strongly phase-separated, heterogeneous materials. A noninteracting domain model developed for sorption in phase-separated glassy polymer blends suggests that sorption in the Henry's law regions (i.e., the equilibrium, dense phase of the blends) is consistent with the model. However, Langmuir capacity parameters in the blends are lower than predicted from the domain model, suggesting that the amount of nonequilibrium excess free volume associated with the Langmuir sites depends on blend composition. © 1996 John Wiley & Sons, Inc.
SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner (2011)

Inhibitors of apoptosis proteins (IAP) are key regulators of apoptosis and are inhibited by the second mitocondrial activator of caspases (SMAC). Previously, a small subset of TNF-α-expressing non-small cell lung cancers (NSCLC) was found to be sensitive to SMAC mimetics alone. In this study, we determined if a SMAC mimetic (JP1201) could sensitize nonresponsive NSCLC cell lines to standard chemotherapy. We found that JP1201 sensitized NSCLCs to doxorubicin, erlotinib, gemcitabine, paclitaxel, vinorelbine, and the combination of carboplatin with paclitaxel in a synergistic manner at clinically achievable drug concentrations. Sensitization did not occur with platinum alone. Furthermore, sensitization was specific for tumor compared with normal lung epithelial cells, increased in NSCLCs harvested after chemotherapy treatment, and did not induce TNF-α secretion. Sensitization also was enhanced in vivo with increased tumor inhibition and increased survival of mice carrying xenografts. These effects were accompanied by caspase 3, 4, and 9 activation, indicating that both mitochondrial and endoplasmic reticulum stress-induced apoptotic pathways are activated by the combination of vinorelbine and JP1201. Chemotherapies that induce cell death through the mitochondrial pathway required only inhibition of X-linked IAP (XIAP) for sensitization, whereas chemotherapies that induce cell death through multiple apoptotic pathways required inhibition of cIAP1, cIAP2, and XIAP. Therefore, the data suggest that IAP-targeted therapy using a SMAC mimetic provides a new therapeutic strategy for synergistic sensitization of NSCLCs to standard chemotherapy agents, which seems to occur independently of TNF-α secretion.
Probing Bilayer Grain Boundaries in Large‐Area Graphene with Tip‐Enhanced Raman Spectroscopy (2016)

The bilayer grain boundaries (GBs) in chemical-vapor-deposition-grown large-area graphene are identified using multispectral tip-enhanced Raman imaging with 18 nm spatial resolution. The misorientation angle of the bilayer GBs is determined from a quantitative analysis of the phonon-scattering properties associated with the modified electronic structure.
Canonical XML Version 1.0 (2001)

Any XML (Extensible Markup Language) document is part of a set of XML documents that are logically equivalent within an application context, but which vary in physical representation based on syntactic changes permitted by XML 1.0 and Namespaces in XML.This specification describes a method for generating a physical representation, the canonical form, of an XML document that accounts for the permissible changes.Except for limitations regarding a few unusual cases, if two documents have the same canonical form, then the two documents are logically equivalent within the given application context.Note that two documents may have differing canonical forms yet still be equivalent in a given context based on application-specific equivalence rules for which no generalized XML specification could account.
Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum (2007)

Diabetic gastroparesis is a disorder that predominantly affects women. However, the biological basis of this sex bias remains completely unknown. In this study we tested the hypothesis that a component of this effect may be mediated by the nitrergic inhibitory system of the enteric nervous system. Age-matched male and female Sprague-Dawley rats were studied 8 or 12 wk after streptozotocin (55 mg/kg body wt ip)-induced sustained hyperglycemia and compared with controls. Solid gastric emptying (GE) studies were performed in all the groups. Changes in gastric antrum neuronal nitric oxide synthase (nNOS) mRNA and protein levels were analyzed by real-time PCR and Western immunoblotting, respectively. nNOS dimerization studies were performed using low-temperature SDS-PAGE. In vitro nitrergic relaxation (area under curve/mg tissue wt) was studied after the application of electric field stimulation in an organ bath. Changes in intragastric pressure (mmHg.s) in freely moving rats in the presence or absence of N(G)-nitro-l-arginine methyl ester (nitric oxide synthase inhibitor) were examined by an ambulatory telemetric method. After diabetes induction, GE is delayed in both male and female rats. However, diabetic females exhibited significant delayed GE than in diabetic males. Compared with male controls, gastric nNOS expression and nitrergic relaxation were substantially elevated in healthy female control rats, accompanied by significantly reduced intragastric pressure. The active dimeric form and dimer-to-monomer ratio of nNOSalpha were also higher in healthy females compared with male rats (P < 0.05). Diabetic females, but not males, showed significant (P < 0.05) impairment in both gastric nNOSalpha dimerization and nitrergic relaxation, accompanied by an increase in intragastric pressure. Our data provide evidence that females may have a greater dependency on the nitrergic mechanisms in health. Furthermore, diabetes seems to affect the nitrergic system to a greater extent in females than in males. Together, these changes may account for the greater vulnerability of females to diabetic gastric dysfunction.
<title>Quality models for audiovisual streaming</title> (2006)

Quality is an essential factor in multimedia communication, especially in compression and adaptation. Quality metrics can be divided into three categories: within-modality quality, cross-modality quality, and multi-modality quality. Most research has so far focused on within-modality quality. Moreover, quality is normally just considered from the perceptual perspective. In practice, content may be drastically adapted, even converted to another modality. In this case, we should consider the quality from semantic perspective as well. In this work, we investigate the multi-modality quality from the semantic perspective. To model the semantic quality, we apply the concept of "conceptual graph", which consists of semantic nodes and relations between the nodes. As an typical of multi-modality example, we focus on audiovisual streaming service. Specifically, we evaluate the amount of information conveyed by a audiovisual content where both video and audio channels may be strongly degraded, even audio are converted to text. In the experiments, we also consider the perceptual quality model of audiovisual content, so as to see the difference with semantic quality model.
1GHz instantaneous wide-band analog predistortion linearizer for new Telecom satellite transmit section (2012)

This paper proposes a new predistortion linearizer module for TWTA enabling to use broadband multi-carrier signals for new Telecom satellite transmit sections. A state-of-the-art NPR performance was obtained over the entire 10.7-12.75GHz Ku-band for multi-carrier signals up to, at least, 1GHz instantaneous bandwidth.
ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis (2023)

Our results show that anchorage-independent survival and growth of cancer cells are supported by changes in genes and proteins that drive glucose metabolism towards an enhanced lactate production. Notably, this finding is valid for all lung and breast cancer cell lines we have analyzed in different nutrient environmental conditions. broader Validation of this mechanism in other cancer cells of different origin will be necessary to broaden the role of ALDOC and ENO2 to other tumor types. Future in vivo studies will be necessary to assess the role of ALDOC and ENO2 in cancer metastasis.
Dielectric breakdown in high-ε films for ulsi drams (1993)

Dielectric breakdown has been studied in several materials intended for high-dielectric DRAMs (dynamic random access memories), emphasizing lead zirconate-titanate (PZT) and barium strontium titanate (BST) ceramics. In this paper recent results from PZT are presented. In order to distinguish among impulse thermal breakdown, dc thermal breakdown, and avalanche breakdown mechanisms, studies have been carried out as functions of temperature, electrode material and shape, frequency and duration of applied fields, and specimen size and shape. Notable in the results is the fact that maximum breakdown field varies directly with electrode work function but is uncorrelated with electrode thermal conductivity; this militates against a purely thermal breakdown interpretation and instead favors an avalanche mechanism in which the initial step is electronic followed by thermal run-away. Thickness dependence also favors avalanche mechanisms, but dependence upon applied field ramp rate favors an impulse thermal mechanism.
Geometric representation of the infimax S-adic family (2017)

We construct geometric realizations for the infimax family of substitutions by generalizing the Rauzy–Canterini–Siegel method for a single substitution to the S-adic case. The composition of each countably infinite subcollection of substitutions from the
Biomechanical Evaluation of Two Different Screw Positions for Fusion of the Calcaneocuboid Joint (1999)

In triple arthrodesis performed for severe deformity and neuroarthropathy in poorly compliant patients with os-teoporotic bone, fixation of the arthrodesis is critical. We biomechanically tested an alternative means of stabilization for calcaneocuboid fusions. In seven matched pairs of fresh-frozen cadaver feet, we removed the soft tissue from around the calcaneocuboid joint, except for the capsule, and we did not resect the articular cartilage. One joint of each pair was fixed with an oblique standard screw, and the contralateral joint was stabilized with an axial screw placed perpendicularly to the joint surface. Testing on an MTS Mini Bionix Test Frame (MTS Systems Corp., Eden Prairie, MN) demonstrated that the axial screw provided significantly higher initial stiffness and maximum load to failure. We concluded that an axial screw provided better fixation of the calcaneocuboid joint.
Rapid and Quantitative Assessment of Cell Quality, Identity, and Functionality for Cell-Based Assays Using Real-Time Cellular Analysis (2011)

Strict quality control of cells is required for the standardization and interpretation of results in all areas of cell-based research, especially in drug discovery. Real-time cellular analysis using electrical impedance as a readout offers a rapid and highly reproducible method for quality control as it provides a quantitative measure of overall cell morphology and growth. In a case study, the authors demonstrate that samples of a single cell line obtained from several different labs show clear differences in their impedance profiles when compared with the corresponding standard cell line. A number of kinetic parameters were derived from the impedance profiles and used to quantify the differences among these cell lines. Our findings indicate that this methodology can detect cell line differences including mix-ups or contaminations, genetic alterations, and potential epigenetic changes occurring during passaging, all of which can occur in the time scale of a screening campaign. Finally, we provide evidence that these impedance profile differences can be predictive of different outcomes in cell-based functional assays for the effects of small molecules on otherwise seemingly identical cell lines.
Language and Logic (1985)

In this volume Van der Auwera attempts to clarify the idea that language reflects both mind and reality and to elucidate the reflection idea by turning it into the cornerstone of a linguistic theory of meaning.
Measurement of Performance of a Peripheral Vision Lipreading Aid (1991)

Lipreading, as the most important tool of speech understanding for profoundly deaf people, carries only a limited amount of information about speech. We explored the usefulness of a peripheral vision display in providing profoundly deaf people with supplementary information to lipreading. A pair of eyeglasses with a commercially available two-dimensional red LED array, and associated electronics was developed. The display is located on the rim of the eyeglasses in the temporal field and the horizontal meridian of the right eye. Selected speech features were encoded as visual patterns for presentation to the lipreader. These features (the fundamental frequency of the speech, high-frequency energy, and low-passed speech signal or total energy envelope) provide information about voicing and plosion/friction in order to supplement lipreading. Experiments with 3 normal and 5 deaf subjects demonstrated the capability of the aid to convey speech information for video taped vowel—consonant-vowel (VCV) nonsense syllables. Average identification of 12 VCV syllables using the aid was about 76%, as compared with 40% without the aid.
Auditory nerve fiber responses to electric stimulation: Modulated and unmodulated pulse trains (2001)

Many modern cochlear implants use sound processing strategies that stimulate the cochlea with modulated pulse trains. Rubinstein et al. [Hear. Res. 127, 108 (1999)] suggested that representation of the modulator in auditory nerve responses might be improved by the addition of a sustained, high-rate, desynchronizing pulse train (DPT). In addition, activity in response to the DPT may mimic the spontaneous activity (SA) in a healthy ear. The goals of this study were to compare responses of auditory nerve fibers in acutely deafened, anesthetized cats elicited by high-rate electric pulse trains delivered through an intracochlear electrode with SA, and to measure responses of these fibers to amplitude-modulated pulse trains superimposed upon a DPT. Responses to pulse trains showed variability from presentation to presentation, but differed from SA in the shape of the envelope of the interval histogram (IH) for pulse rates above 4.8 kpps (kilo pulses per second). These IHs had a prominent mode near 5 ms that was followed by a long tail. Responses to modulated biphasic pulse trains resembled responses to tones in intact ears for small (<10%) modulation depths, suggesting that acousticlike responses to sinusoidal stimuli might be obtained with a DPT. However, realistic responses were only observed over a narrow range of levels and modulation depths. Improved coding of complex stimulus waveforms may be achieved by signal processing strategies for cochlear implants that properly incorporate a DPT.
Optical Rotatory Dispersion of 2,3-Hexadiene and 2,3-Pentadiene (2008)

The specific rotation of (P)-2,3-hexadiene (1) was measured as a function of wavelength for the gas phase, the neat liquid, and solutions. There was a surprisingly large difference between the gas phase and condensed phase values. The specific rotation was calculated using B3LYP and CCSD, and the difference in energy between the three low energy conformers was estimated at the G3 level. The Boltzmann-averaged CCSD-calculated rotations using the gauge independent velocity gauge representation, as well as the B3LYP values, are in agreement with the gas-phase experimental values. In order to avoid possible problems associated with the conformers of 1, 2,3-pentadiene (2) also was examined. Here again, there was a large difference between the gas-phase and condensed-phase specific rotations, with the CCSD velocity gauge (and B3LYP) results being close to the gas-phase experimental values. The possibility that 2,3-pentadiene could be distorted on going from the gas to liquid phase, thereby accounting for the effect of phase on the specific rotation, was examined via a Monte Carlo statistical mechanics simulation. No effect on the geometry was found. Specific rotations of 1 found in solutions were similar to those for the liquid phase, indicating that the phase difference was not due to association.
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors (2016)

The majority of potent and selective hNaV1.7 inhibitors possess common pharmacophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group. Recently, reports of similar aromatic tail groups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfonamide bestowing levels of selectivity over hNaV1.5 comparable to the heteroaryl sulfonamide. Beginning with commercially available carboxylic acids that met selected pharmacophoric requirements in the lipophilic tail, a parallel synthetic approach was applied to rapidly generate the derived acyl sulfonamides. A biaryl acyl sulfonamide hit from this library was elaborated, optimizing for potency and selectivity with attention to physicochemical properties. The resulting novel leads are potent, ligand and lipophilic efficient, and selective over hNaV1.5. Representative lead 36 demonstrates selectivity over other human NaV isoforms and good pharmacokinetics in rodents. The biaryl acyl sulfonamides reported herein may also offer ADME advantages over known heteroaryl sulfonamide inhibitors.
Particle Gibbs with Ancestor Sampling for Identification of Tire-Friction Parameters (2017)

Particle Gibbs with Ancestor Sampling (PGAS) is a particle Markov chain Monte Carlo method (PMCMC) for Bayesian inference and learning. PGAS conditions on a reference-state trajectory in the underlying particle filter using ancestor sampling. In this paper, we leverage PGAS for identification of cornering-stiffness parameters in road vehicles only using production-grade sensors. The cornering-stiffness parameters are essential for describing the motion of the vehicle. We show how PGAS can be adapted to efficiently learn the stiffness parameters by conditioning on the noise-input trajectory instead of the state trajectory. We verify on a three-minute long experimental test drive that our method correctly identifies the tire-stiffness parameters.
Figure S3 from Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells (2023)

&lt;p&gt;Figure S3. Increased M-MDSC subset in tumor infiltrates from Fasl-/- mice.&lt;/p&gt;
Synthesis and Characterization of Carbazolide-Based Iridium PNP Pincer Complexes. Mechanistic and Computational Investigation of Alkene Hydrogenation: Evidence for an Ir(III)/Ir(V)/Ir(III) Catalytic Cycle (2014)

New carbazolide-based iridium pincer complexes ((carb)PNP)Ir(C2H4), 3a, and ((carb)PNP)Ir(H)2, 3b, have been prepared and characterized. The dihydride, 3b, reacts with ethylene to yield the cis-dihydride ethylene complex cis-((carb)PNP)Ir(C2H4)(H)2. Under ethylene this complex reacts slowly at 70 °C to yield ethane and the ethylene complex, 3a. Kinetic analysis establishes that the reaction rate is dependent on ethylene concentration and labeling studies show reversible migratory insertion to form an ethyl hydride complex prior to formation of 3a. Exposure of cis-((carb)PNP)Ir(C2H4)(H)2 to hydrogen results in very rapid formation of ethane and dihydride, 3b. DFT analysis suggests that ethane elimination from the ethyl hydride complex is assisted by ethylene through formation of ((carb)PNP)Ir(H)(Et)(C2H4) and by H2 through formation of ((carb)PNP)Ir(H)(Et)(H2). Elimination of ethane from Ir(III) complex ((carb)PNP)Ir(H)(Et)(H2) is calculated to proceed through an Ir(V) complex ((carb)PNP)Ir(H)3(Et) which reductively eliminates ethane with a very low barrier to return to the Ir(III) dihydride, 3b. Under catalytic hydrogenation conditions (C2H4/H2), cis-((carb)PNP)Ir(C2H4)(H)2 is the catalyst resting state, and the catalysis proceeds via an Ir(III)/Ir(V)/Ir(III) cycle. This is in sharp contrast to isoelectronic (PCP)Ir systems in which hydrogenation proceeds through an Ir(III)/Ir(I)/Ir(III) cycle. The basis for this remarkable difference is discussed.
“A light heart and a thin pair of breeches” (1873)

Journal Article “A light heart and a thin pair of breeches” Get access W. Chappell W. Chappell Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s4-XI, Issue 276, 12 April 1873, Page 308, https://doi.org/10.1093/nq/s4-XI.276.308c Published: 12 April 1873
Fas-Associated Death Receptor Signaling Evoked by Human Amylin in Islet β-Cells (2007)

This is the first report linking hA-evoked induction and activation of Fas and FADD to beta-cell apoptosis. We have identified a Fas/FasL antagonist, Kp7-6, as a potent inhibitor of hA aggregation and related beta-cell death. These results also support an interaction between hA and Fas on the surface of apoptotic beta-cells. Increased expression and activation of Fas in beta-cells could constitute a molecular event common to the pathogenesis of both type 1 and type 2 diabetes, although the mode of pathway activation may differ between these common forms of diabetes.
Supplementary Figure 4 from Impact of Screening Test Performance and Cost on Mortality Reduction and Cost-effectiveness of Multimodal Ovarian Cancer Screening (2023)

&lt;p&gt;PDF file - 62K, Age-specific ovarian cancer survival curves by histology, stage and grade&lt;/p&gt;
Recent progress on silica-based thermooptic switches for ADMs/XCs (2003)

Space-division optical switches are key devices for achieving wavelength-division-multiplexing (WDM) optical-path cross-connect (OXC) functions, and optical add/drop multiplexing (OADM) functions for future photonic network systems designed to offer multimedia communication at a high bit rate. Silica-based thermooptic switches, which employ planar lightwave circuit (PLC) technology, are promising devices for use in practical systems. This is because they offer many advantages including low insertion loss, polarization-insensitive operation, long-term stability, the feasibility of large-scale integration, and moreover are suitable for mass-production. In this presentation, we describe recent progress on our silica-based thermooptic switches. The fabricated large-scale thermooptic switches considered include: an N/spl times/N matrix switch, a 1/spl times/N tree structure switch and an ADM switch.