gebhart/patrepeval huggingface dataset:
Perineural tumor spread to the muscle: An alternative for muscle metastasis? (2014)

Clinical AnatomyVolume 28, Issue 5 p. 560-562 Letter to the Editor Perineural tumor spread to the muscle: An alternative for muscle metastasis? Stepan Capek, Stepan Capek Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech RepublicSearch for more papers by this authorKimberly K. Amrami, Kimberly K. Amrami Department of Radiology, Mayo Clinic, Rochester, MinnesotaSearch for more papers by this authorBenjamin M. Howe, Benjamin M. Howe Department of Radiology, Mayo Clinic, Rochester, MinnesotaSearch for more papers by this authorRobert J. Spinner, Corresponding Author Robert J. Spinner Department of Neurosurgery, Mayo Clinic, Rochester, MNCorrespondence to: Robert J. Spinner, M.D., Gonda 8-214, 200 First Street SW, Rochetster, MN 55905, USA. E-mail: spinner.robert@mayo.eduSearch for more papers by this author Stepan Capek, Stepan Capek Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech RepublicSearch for more papers by this authorKimberly K. Amrami, Kimberly K. Amrami Department of Radiology, Mayo Clinic, Rochester, MinnesotaSearch for more papers by this authorBenjamin M. Howe, Benjamin M. Howe Department of Radiology, Mayo Clinic, Rochester, MinnesotaSearch for more papers by this authorRobert J. Spinner, Corresponding Author Robert J. Spinner Department of Neurosurgery, Mayo Clinic, Rochester, MNCorrespondence to: Robert J. Spinner, M.D., Gonda 8-214, 200 First Street SW, Rochetster, MN 55905, USA. E-mail: spinner.robert@mayo.eduSearch for more papers by this author First published: 15 December 2014 https://doi.org/10.1002/ca.22485Citations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume28, Issue5July 2015Pages 560-562 RelatedInformation
Implementing logic in FPGA memory arrays: heterogeneous memory architectures (2003)

It has become clear that large embedded configurable memory arrays will be essential in future FPGAs. Embedded arrays provide high-density high-speed implementations of the storage parts of circuits. Unfortunately, they require the FPGA vendor to partition the device into memory and logic resources at manufacture-time. This leads to a waste of chip area for customers that do not use all of the storage provided This chip area need not be wasted, and can in fact be used very efficiently, if the arrays are configured as large multi-output ROMs, and used to implement logic. In this paper we investigate how the architecture of the FPGA embedded arrays affects their ability to implement logic. Specifically, we focus on architectures which contain more than one size of memory array. We show that these heterogeneous architectures result in significantly denser implementations of logic than architectures with only one size of memory array. We also show that the best heterogeneous architecture contains both 2048 bit arrays and 128 bit arrays.
VP6: Sustained Topical Release of Tacrolimus Promotes Corneal Reinnervation in Rats (2022)

INTRODUCTION: Corneal nerve fibers provide sensibility and maintain ocular surface health. Impaired corneal innervation results in progressive corneal breakdown and vision loss termed neurotrophic keratopathy. Non-surgical therapies that promote corneal reinnervation and thereby prevent vision loss are presently unavailable. MATERIALS AND METHODS: In a compartmentalized neuronal cell culture system only the axonal compartments were exposed to either Tacrolimus (50 ng/ml, n=15) or a vehicle (n=9). After 48h, the axonal surface area and axon length were measured. A biodegradable drug-delivery-system (DDS) was fabricated via electrospinning of a Tacrolimus loaded polycarbonte-urethane-polymer (100 µg Tacrolimus per DDS) which achieved sustained Tacrolimus release for >31 days. Effectiveness was tested in a rat model of neurotrophic keratopathy. Adult rats (n=16) underwent trigeminal nerve ablation and received either a Tacrolimus DDS topically before tarsorrhaphy or tarsorrhaphy only. After 28 days, the normalized corneal nerve fiber density was determined and Tacrolimus biodistribution was assessed via mass spectrometry. RESULTS: Sensory neurons whose axons were exposed to Tacrolimus regenerated significantly more axons (surface area: 2.46±0.7mm2 vs. 0.45±0.2mm2; p<0.001) that were significantly longer on average (2.49±0.5mm vs. 0.84±0.39 mm; p < 0.001) compared to vehicle treated cultures. In agreement with the in vitro results, rats that had received Tacrolimus topically showed significantly higher corneal nerve fiber density (1.48±0.68) compared to the non-treated control (0.19±0.18; p < 0.001) and 7-days post denervation (0.07±0.04; p < 0.001). Tacrolimus was detectable in the ipsilateral vitreal body (3.2±1.9 ng/g), the plasma (1.3±0.7 ng/ml) and the ipsilateral trigeminal ganglion (0.6±0.1 ng/g) but not in their contralateral counterparts or vital organs (liver, kidey, heart) 28-days post denervation. CONCLUSION: Local delivery of low-dose Tacrolimus accelerates sensory axon regeneration in vitro and corneal reinnervation in vivo with minimal systemic drug exposure. Therefore, topically applied Tacrolimus may provide a readily translatable approach to promote corneal reinnervation in patients suffering from corneal nerve fiber loss.
10GHz Tunable Slow Light in 1.3 μm Quantum Dot Vertical-Cavity Surface-Emitting Lasers Amplifier (2006)

This investigation experimentally demonstrates tunable slow light by varying the bias currents in a 1.3 μm quantum dot vertical-cavity surface-emitting laser. The maximum delay of 42 ps at 10 GHz is achieved.
Preliminary cosmic microwave background anisotropy results from the MAXIMA balloon borne experiment (2000)

We present preliminary cosmic microwave background anisotropy results from the first flight of the MAXIMA balloon borne experiment. The flight (MAXIMA-1) took place in August of 1998 from the National Scientific Ballooning Facility in Palestine, Texas. During the four hour flight we mapped a 124 deg2 section of the sky which has extremely low galactic dust contamination. The combination of the beam size and scan strategy make MAXIMA sensitive to CMB fluctuations on a range of angular scales from 10 arcmin to 5 degrees. The instrument consists of a Gregorian telescope with a 1.3m primary mirror and a receiver housing a 16 element bolometer array cooled to 100mK. Observations were made at 3 frequency bands centered on 150, 240, and 410 GHz. The results presented will include a map of the CMB anisotropy at 150 GHz. We will also briefly describe the second MAXIMA flight that took place in June of 1999. During this flight we observed 230 deg2 of sky with very low galactic dust contamination. About 20% of this region overlaps the MAXIMA-1 map. The MAXIMA experiment is supported by NASA through grant Nos. NAG5-4454, and NAG5-3941, and by the Center for Particle Astrophysics, a National Science Foundation Science and Technology Center operated by the University of California, Berkeley, under Cooperative Agreement No. AST-9120005.
Flexural Creep of an in Situ ‐Toughened Silicon Carbide (2001)

Flexural creep behavior is reported for an in situ ‐toughened SiC between 1100° and 1500°C in four‐point bending. The flexural creep rate of this SiC, sintered with aluminum, boron, and carbon (ABC‐SiC), exhibits linear stress dependence, low apparent activation energy, and low incidence of cavitation and dislocation production. Most grain boundaries in this ceramic contain 1–5 nm intergranular films. The creep rate is consistent with a grain‐boundary transport mechanism involving diffusion along the grain‐boundary film‐SiC interfaces. The microstructure and grain boundaries have been examined using transmission electron microscopy to assess possible changes during creep, particularly in relation to the applied stress direction.
Kilometer length low loss enhanced back scattering fiber for distributed sensing (2017)

We demonstrate a 1km long optical fiber with continuous grating enhanced back scattering and attenuation close to standard single mode fiber. Scattering was observed to be more than 10dB above the Rayleigh back scattering of the optical fiber over a 10nm bandwidth between 1542 and 1552nm. The fiber attenuation was estimated to be 0.4dB/km. Our result was enabled through the fabrication of a standard single mode fiber with a UV transparent coating and reel to reel continuous UV grating inscription over more than 1km. We anticipate that enhanced scattering fiber will have impact in many sensor systems that rely on optical back scatter, including distributed acoustic sensing, security applications and structural health monitoring.
Targeted Collection of Plasmid DNA in Large and Growing Animal Muscles 6 Weeks after DNA Vaccination with and without Electroporation (2015)

International audience
Abstract A63: Identification of small molecules for GBM study (2016)

Abstract Glioblastoma Multiforme (GBM) is the most frequent of malignant tumors of the brain. It is fatal usually within fifteen months after diagnosis. The Cancer Genome Atlas (TCGA) has surveyed the genomes of hundreds of human GBMs for presence of mutations in genes previously associated with cancer. Among those identified, three of the five most frequently mutated genes encode the well-known tumor suppressors: P53, NF1, and Pten (TCGA, 2008). We have generated genetic mouse models of GBM based on mutation in these same three tumor suppressors and they develop GBM with 100% incidence. These mouse GBMs resemble the human counterparts by all commonly used criteria for diagnosis. Extensive study of these mice and tumors has provided novel insights into the natural history of GBM development and moreover pointed at the adult neural stem cell/progenitor compartment as the most likely and frequent source of these tumors (Kwon CH, et al., 2008). We have thus isolated a cancer stem cell and demonstrated a hierarchical growth for these tumors in vivo. (Chen J, et al., 2012) In an effort to identify novel GBM specific molecular pathways that might serve as therapeutic targets, we undertook a 200,000 small compound high throughput screen using primary low passage GBM cells generated by pooling cells from multiple mouse tumors (Mut6 cells). A critical counter screen was designed to minimize compounds that targeted the cell division and DNA replication machinery of cells since many normal cells divide and this property is not unique to cancer cells. We therefore ruled out all compounds that displayed toxicity to primary mouse embryo fibroblasts (MEFs) or to primary astrocytes. At the end of the screen, we selected three lead compounds with amenable physical-chemical properties for further evaluation and development as research discovery reagents and possible translational tools for drug development. We verified the activity of one of these compounds, termed Compound X, on mouse and human GBM primary cells as well as on a subset of established cancer cell lines, but not on MEFs or primary astrocytes. We identified a rapid cellular stress response accompanied by the robust activation of a transcription factor and eventual apoptotic response that can be mimicked by glucose deprivation. Through intensive structure-activity relationship study, analogs were successfully developed for in vivo activity and also for biochemical pull-down assay. Another compound (Compound Y) also induced apoptosis, however displaying response through completely different pathway, which indicates our screen identified multiple vulnerabilities in GBM tumor cells. Citation Format: Sang Kyun Lim, Yufeng Shi, Qiren Liang, Inga Nazarenko, Shuguang Wei, Maya Palnitkar, Yanjiao Li, Woosung Cho, Noelle Williams, Bruce Posner, Jef De Brabander, Luis F. Parada. Identification of small molecules for GBM study. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A63.
Adaptive Video Streaming Using Bandwidth Estimation for 3.5G Mobile Network (2009)

Currently deployed mobile networks including High Speed Downlink Packet Access (HSDPA) offer only best-effort Quality of Service (QoS). In wireless best effort networks, the bandwidth variation is a critical problem, especially, for mobile devices with small buffers. This is because the bandwidth variation leads to packet losses caused by buffer overflow as well as picture freezing due to high transmission delay or buffer underflow. In this paper, in order to provide seamless video streaming over HSDPA, we propose an efficient real-time video streaming method that consists of the available bandwidth (AB) estimation for the HSDPA network and the transmission rate control to prevent buffer overflows/underflows. In the proposed method, the client estimates the AB and the estimated AB is fed back to the server through real-time transport control protocol (RTCP) packets. Then, the server adaptively adjusts the transmission rate according to the estimated AB and the buffer state obtained from the RTCP feedback information. Experimental results show that the proposed method achieves seamless video streaming over the HSDPA network providing higher video quality and lower transmission delay.
A case‐control analysis of lymphocytic chromosome 9 aberrations in lung cancer (2002)

Cytogenetic aberrations on chromosome 9 have been reported to be one of the most frequent genetic changes in lung tumorigenesis. Although many of these changes have been detected in lung carcinoma specimens, there is growing evidence showing the concordance between chromosomal alterations in primary lung tumors and peripheral blood lymphocytes (PBLs). We investigated whether spontaneous aberrations on chromosome 9 in PBLs are associated with the presence of lung cancer and with a family history of cancer. A personal interview, to construct a detailed epidemiologic profile including family history of cancer, was conducted on 174 lung cancer cases and 162 matched controls. One hundred metaphases from PBLs of each subject were analyzed for chromosome 9 aberrations using the whole chromosome painting technique. Overall, the mean proportion of individuals with chromosome 9 abnormalities in their PBLs was significantly higher in cases (96.0%) than in controls (60.5%) (p < 0.05). After adjustment by age, gender, ethnicity, family size, and pack-years, there was a 16.63-fold significantly elevated odds ratio (OR) for lung cancer associated with chromosome 9 aberrations. When subjects were categorized by frequencies of the chromosome 9 lesions, we observed significantly increased odds ratios of 11.13 (4.66, 26.58) and 27.45 (11.15, 67.54) for individuals with 1 chromosome 9 aberration and >/=2 chromosome 9 aberrations, respectively. By performing family history analyses, we further observed that control individuals with chromosome 9 aberrations were more likely to report a family history of any cancer (OR = 1.67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer.
An Integrated Optical Head Using a Crystal Micro-Prism for MiniDisc Systems. (2002)

We developed an integrated optical device for MiniDisc MO recording systems. The simple configuration and manufacturing process of the device were realized through developing ray-tracing and diffraction integral methods for crystals and employing a simple micro-prism of a birefringent crystal KTP (KTiOPO4). We confirmed that an optical head using the device had adequate quality and reliability for practical use.
Digital agriculture for small-scale producers (2021)

Smart Farming with technologies such as IoT, computer vision, and AI can improve agricultural efficiency, transparency, profitability, and equity for farmers in low-and middle-income countries.
Facile and Green Approach To Fabricate Gold and Silver Coated Superparamagnetic Nanoparticles (2009)

Superparamagnetic magnetite nanoparticles are coated with homogeneous gold and silver shells using a simple aqueous based seed mediated method at room temperature with dopamine as a surfactant. Nanoparticles of Au in the range 2−3 nm are attached to amine functionalized Fe3O4 nanoparticles, acting as seed for the growth of ultrathin Au or Ag shells. The monodispersed core−shell nanoparticles Fe3O4@Au and Fe3O4@Ag have a particle size range of 10−13 nm with a shell thickness of approximately 2−3 nm. They are magnetically purified and are superparamagnetic at 300 K with saturated magnetization values of 41 and 35 emu g−1, respectively.
Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures (2004)

Use of our surgical protocol for elbow dislocations with associated radial head and coronoid fractures restored sufficient elbow stability to allow early motion postoperatively, enhancing the functional outcome. We recommend early operative repair with a standard protocol for these injuries.
Designing a Coupling That Guarantees Synchronization between Identical Chaotic Systems (1997)

We examine synchronization between identical chaotic systems. A rigorous criteria is presented which, if satisfied, guarantees that the coupling produces linearly stable synchronous motion. The criteria can also be used to design couplings that lead to stable synchronous motion. Analytical results from a dynamical system are presented.
A New Dynamic Model of a Dual Active Bridge DC-DC Converter (2021)

The paper proposes a new model for a dual active bridge DC-DC converter. The model is developed in time-domain and it takes into account the effective waveform of all the quantities of interest. The paper introduces some algebraic and integral operations useful for modeling the converter defining some “support functions”. Starting by these functions a full analytical model of the DAB is deduced. The effectiveness of the suggested analytical model has been tested and confirmed by simulations and experiments with a 3 kW prototype 28/270 V.
OPTICAL CLOCK DISTRIBUTION USING A MODE-LOCKED SEMI-CONDUCTIOR LASER DIODE SYSTEM (1991)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text PETER J. DELFYETT, DAVIS H. HARTMANN, and S. ZUBER AHMAD, "OPTICAL CLOCK DISTRIBUTION USING A MODE-LOCKED SEMI-CONDUCTIOR LASER DIODE SYSTEM," Optics & Photonics News 2(12), 34-34 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Playback Synchronization Techniques for Networked Home Appliances (2007)

This paper addresses the problem of device synchronization, particularly as it manifests on wireless home networks. Basic clock synchronization can be achieved between two independent devices over a packet network using the network time protocol (NTP). However, as the D/A stages of the two devices may introduce additional clock skew more sophisticated approaches are required to achieve the necessary level of device synchronization for high quality playback of audio data. Practical applications in the fields of VOIP telephony and audiophile quality speaker synchronization are discussed.
Implementation and application of a method to quantitate 2‐D gel electrophoresis patterns (1983)

Abstract We describe a system for accurate photometry and analysis of two‐dimensional (2‐D) gels, and its application to both high and low resolution gels. Image acquisition is video‐based and includes methods of data correction necessary for accurate photometry. The analysis is based upon a method described previously by Lutin et al. [8], which we have modified for improved stability and adapted to run on our PDP 11/60 computer. We illustrate analysis of a typical gel with a sequence of images showing the data while Gaussian components are estimated, removed, added and fitted as the iterative algorithm proceeds. We conclude by demonstrating the use of a mathematical curve‐of‐growth model for calibrating peak volumes vs. protein loading.
Precision targeting of liver lesions using a novel electromagnetic navigation device in physiologic phantom and swine (2005)

Radiofrequency ablation of primary and metastatic liver tumors is becoming a potential alternative to surgical resection. We propose a novel system that uses real-time electromagnetic position sensing of the needle tip to help with precision guidance into a liver tumor. The purpose of this study was to evaluate this technology in phantom and animal models. Using an electromagnetic navigation device, instrumented 18 g needles were advanced into radioopaque tumor targets in a respiratory liver phantom. The phantom featured a moving liver target that simulated cranio-caudal liver motion due to respiration. Skin-to-target path planning and real-time needle guidance were provided by a custom-designed software interface based on pre-operative 1 mm CT data slices. Needle probes were advanced using only the electromagnetic navigation device and software display. No conventional real-time imaging was used to assist in advancing the needle to the target. Two experienced operators (interventional radiologists) and two inexperienced ones (residents) used the system. The same protocol was then also used in two anesthetized 45 kg Yorkshire swine where radioopaque agar nodules were injected into the liver to serve as targets. A total of 76 tumor targeting attempts were performed in the liver phantom, and 32 attempts were done in the swine. The average time for path planning was 30 s in the phantom, and 63 s in the swine. The median time for the actual needle puncture to reach the desired target was 33 s in the phantom, and 42 s in the swine. The average registration error between the CT coordinate system and electromagnetic coordinate system was 1.4 mm (SD 0.3 mm) in the phantom, and 1.9 mm (SD 0.4 mm) in the swine. The median distance from the final needle tip position to the center of the tumor was 6.4 mm (SD 3.3 mm, n=76) in the phantom, and 8.3 mm (SD 3.7 mm, n=32) in the swine. There was no statistical difference in the planning time, procedure time, or accuracy of needle placement between experienced and inexperienced operators. The novel electromagnetic navigation system allows probe delivery into hepatic tumors of a physiologic phantom and live anesthetized swine. The system allows less experienced operators to perform equally well as experienced radiologists in terms of procedure time and accuracy of needle probe delivery.
Different MHC class I alleles compete for presentation of overlapping viral epitopes (2021)

We previously identified an HLA-B8+ donor, NW, whose lymphoblestoid cells failed to present a B8-restricted epitope from the influenza A nucleoprotein following viral infection, although added peptide could still be presented. The failure to present through HLA-B8 following viral infection appears to be specific for the NP epitope. Here, we report that donor NW makes an HLA-132702-restricted influenza-specific CTL response to an epitops in the nucleoprotein that overlaps the 138-restricted epitope by 8 aa. Two mechanisms for the failure of this cell line to present the 138-restricted epitope following viral infection are investigated. One is that there is an antigen processing polymorphism specific to the NW cell line, so that there is either preferential generation or preferential transport of the B27702 epitope. The other is that 138 and 132702 compete for a common peptide fragment in the ER and this leads to suboptimal loading of HLA-138.