gebhart/patrepeval huggingface dataset:
A 6-phase harmonic rejection down-converter with digital assist (2010)

A down-converter insensitive to 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> and 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> harmonics and a digital assisting circuit that cancels residual sensitivity due to device mismatches are proposed. Measured 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3rd</sup> harmonic rejection ratios of over 60 dB are achieved. This performance allows a simple RF filter, and it is effective to reduce the die size.
Catalytic Enantioselective Intramolecular C(sp3)−H Amination of 2‐Azidoacetamides (2018)

Abstract An enantioselective ring‐closing C(sp 3 )−H amination of 2‐azidoacetamides is catalyzed by a chiral‐at‐metal ruthenium complex and provides chiral imidazolidin‐4‐ones in 31–95 % yield, with enantioselectivities of up to 95 % ee , and at catalyst loadings down to 0.1 mol % (turnover number (TON)=740). To our knowledge, this is the first example of a highly enantioselective C(sp 3 )−H amination with aliphatic azides. Mechanistic experiments reveal the importance of the amide group, which presumably enables initial bidentate coordination of the 2‐azidoacetamides to the catalyst. DFT calculations show that the transition state leading to the major enantiomer features a better steric fit and favorable π–π stacking between the substrate and the catalyst framework.
Short‐term liquid storage of umbilical cord blood (2003)

These results indicate that the recovery of cells from cord blood can be improved if samples are stored using a storage solution for 24 hours without significant cell losses. Some of the solutions determined to be effective in maintaining viability are approved for human applications, although not specifically cord blood preservation.
Search for high-mass diboson resonances with boson-tagged jets in proton-proton collisions at s = 8 $$ \sqrt{s}=8 $$ TeV with the ATLAS detector (2015)

A search is performed for narrow resonances decaying into W W , W Z, or ZZ boson pairs using 20.3 fb -1 of proton-proton collision data at a centre-of-mass energy of s = 8 TeV recorded with the ATLAS detector at the Large Hadron Collider. Diboson resonances with masses in the range from 1.3 to 3.0 TeV are sought after using the invariant mass distribution of dijets where both jets are tagged as a boson jet, compatible with a highly boosted W or Z boson decaying to quarks, using jet mass and substructure properties. The largest deviation from a smoothly falling background in the observed dijet invariant mass distribution occurs around 2 TeV in the W Z channel, with a global significance of 2.5 standard deviations. Exclusion limits at the 95% confidence level are set on the production cross section times branching ratio for the W Z final state of a new heavy gauge boson, W , and for the W W and ZZ final states of Kaluza-Klein excitations of the graviton in a bulk Randall-Sundrum model, as a function of the resonance mass. W bosons with couplings predicted by the extended gauge model in the mass range from 1.3 to 1.5 TeV are excluded at 95% confidence level.
Mechanism of production of intestinal secretion by elevated venous pressure. (1976)

A study was carried out to elucidate the physiological mechanisms responsible for the intestinal secretion produced by venous pressure elevation. In dogs, measurements were made of the rate and composition of small intestinal secretion, rate of flow and composition of intestinal lymph, plasma composition, and mucosal water content, all in response to elevations of intestinal venous pressure. Venous pressure elevations above a threshold value of 30-35 cm H2O produce secretion at a rate of approximately proportional to the value of the pressure minus the threshold value. Above the threshold value, there were large increases in the rates of lymph flow and net sustained transcapillary filtration. These rates were also roughly proportional to the incremental venous pressure. It is concluded that intestinal secretion produced by elevated venous pressure is almost surely secretory filtration, a passive process with the driving force for secretion an increase in mucosal tissue fluid pressures to values of only some 4-6 cm H2O. The increased tissue fluid pressure not only provides the driving force but also produces an increase in the hydraulic permeability of the epithelium without which the driving force would be ineffective. The transepithelial channels are large enough to permit insulin to pass freely and even plasma protein to pass in large amounts, and hence are most probably intercellular. Secretory filtration probably represents a general pathophysiological response of transporting epithelia to elevated tissue fluid pressure. It is proposed that the threshold value for secretion and associated changes is explained by dilution of the tissue fluid protein colloid osmotic pressure in a small subepithelial, juxtacapillary compartment.
Epidermal Growth Factor Precursor Is Present in a Variety of Human Renal Cyst Fluids (1995)

Progressive human renal cystic diseases are characterized by proliferation of the epithelial cells lining the cyst. The kidney synthesizes epidermal growth factor and its presence in renal cyst fluid might contribute to renal epithelial cell proliferation. We screened autosomal dominant polycystic kidney disease, acquired renal cystic disease, the von Hippel-Lindau syndrome, multilocular cystic nephroma, multicystic dysplastic kidney disease and simple cyst fluids for the presence of epidermal growth factor by radioreceptor assay, specific radioimmunoassay, immunoprecipitation and immunoblotting. Multiple epidermal growth factor immunoreactive species of approximately 180 kD. and lower molecular weights were present in almost all cyst fluids examined, suggesting endogenous synthesis and limited proteolysis of epidermal growth factor precursor protein in cyst fluid. Tamm-Horsfall protein was detected by enzyme-linked immunosorbent assay in most cysts (for example 55 of 59 autosomal dominant polycystic kidney disease samples). The majority of simple and autosomal dominant polycystic kidney disease renal cysts contained high sodium ion concentration, epidermal growth factor precursor protein and Tamm-Horsfall protein, characteristic of the early thick ascending limb. Rather than the mere presence of epidermal growth factor in renal cyst fluids, increased sensitivity to epidermal growth factor or other mitogens present in renal cyst fluid may be pathogenic in progressive renal cystic disease.
Controlled Formation of Highly Ordered Cubic and Hexagonal Mesoporous Nanocrystalline Yttria–Zirconia and Ceria–Zirconia Thin Films Exhibiting High Thermal Stability (2003)

Yttria–zirconia and ceria–zirconia mesoporous thin films adopt either a cubic or 2D hexagonal mesostructure (see picture) depending on the quantity of water employed during the post-processing of the films. The hexagonal films are thermally stable above 400 °C, while the cubic forms retain their integrity up to 700 °C; both forms continue to be porous at temperatures as high as 800 °C. Such robust and easily prepared crystalline materials may have many useful applications, for example, in the design of sensors, electrode materials, and catalysts. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50147_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Miniaturized and circularly polarized antenna with high front-to-back-ratio in the L1 band for global navigation satellite systems (2023)

A miniaturized, multi-band and circularly polarized (CP) antenna with high Front-to-Back-Ratio (FTBR) in the L1 band for global navigation satellite systems (GNSS) is developed in this paper. The proposed CP antenna consists of four dielectric substrates, each of which forms a folded monopole antenna and a parasitic inverted-L antenna for four frequency bands (L1/L2/L5/L6). To improve a FTBR, a microstrip resonator is situated in the multi-layer substrate beneath the antenna elements. The FTBR is improved by 4.2 dB in the L1 band when compared to the FTBR of the antenna without the microstrip resonator. The measured boresight gain is more than 1.5 dBic over the four bands.
Effect of Bronchial Thermoplasty on Airway Closure (2007)

BACKGROUND: Bronchial Thermoplasty, a procedure that applies thermal energy to the airway wall has been shown to impair the ability of airway to contract in response to methacholine chloride (Mch). The technique has been advocated as an alternative treatment for asthma that may permanently limit airway narrowing. In previous experimental studies in dogs and humans, it was shown that those airways treated with bronchial thermoplasty had significant impairment of Mch responsiveness. METHODS: In the present study, we investigated the ability of canine airways to close completely with very high concentrations of Mch after bronchial thermoplasty. Bronchial thermoplasty was performed on dogs using the Alair System, comprising a low power RF controller and a basket catheter with four electrodes. A local atomization of Mch agonist was delivered directly to the epithelium of the same airway locations with repeated challenges. Airway size was measured with computed tomography, and closure was considered to occur in any airway where the lumen fell below the resolution of the scanner (< 1 mm). RESULTS: Our results show that, while treated airways still have the capacity to close at very high doses of Mch, this ability is seriously impaired after treatment, requiring much higher doses. CONCLUSIONS: Bronchial thermoplasty as currently applied seems to simply shift the entire dose response curve toward increasing airway size. Thus, this procedure simply serves to minimize the ability of airways to narrow under any level of stimulation.
Comparison of Ray Tracing Simulations and Millimeter Wave Channel Sounding Measurements (2007)

Temporal-Angular channel sounding measurements of an indoor millimeter wave channel (60 GHz) is analyzed to determine the location of two dimensional clusters of arrivals at the receiver. The measurement scenarios are also emulated by a ray tracing tool. The results are similarly analyzed to verify possible agreements and determine the effectiveness of such tools in predicting cluster locations as well as ray arrival statistics within clusters in millimeter wave indoor channel.
Human-derived raw materials: Controlled, consistent collections enable successful manufacturing of cell-based regenerative medicine products (TECH1P.847) (2014)

Abstract Human cells are critical raw materials for manufacturing cell therapy products, but introduce significant variability. HemaCare controls apheresis procedures and collection sites under a formal quality system, with GMP-compliant, validated procedures and equipment, and GTP-compliant donor screening and tracking. HemaCare performed 86,799 cellular apheresis collections in the last 7 years for research, clinical trials, and commercial products. HemaCare’s unmobilized apheresis products showed consistently high MNC purity, with 93.8% of products containing ≥75% MNC, and an average of 85.66% MNC±7.1% (mean±1 SD). RBC contamination was low, with hematocrit averaging 1.78%±0.7%. Approximately 85% of HemaCare donors have donated apheresis products 5 or more times. HemaCare’s laboratory is equipped with Miltenyi Biotec technology for isolation of raw material into purified cellular subpopulations. The consistency and viability of the purified end products are measured with flow cytometry. Using BioLife Solutions’ serum-free and protein-free cGMP CryoStor™ cryopreservation media with purified cells, post-thaw recovery rates of cell fractions have been above 95%; dendritic cell and macrophage have demonstrated recovery rates of ≥90%. CryoStor™, in combination with freezing in the BioCision CoolCell™ freezing container, has enabled HemaCare to standardize the cryopreservation process, reducing variability while optimizing post-thaw viable cell recovery of its research products.
A lot of nexts (2015)

Whole-exome sequencing (WES) was featured prominently in the first issue of Neurology® Genetics,(1) and this technology again contributed to identification of a homozygous AMPD2 mutation as the cause of a neurodevelopmental syndrome published in this issue.(2) A different approach to analysis of a large number of exons is described by Tian and collaborators(3) and discussed by Bönnemann and colleagues,(4) both in this issue.
Data from The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation (2023)

&lt;div&gt;Abstract&lt;p&gt;The phosphoinositide 3–kinase (PI3K) pathway regulates proliferation, survival, and metabolism and is frequently activated across human cancers. A comprehensive elucidation of how this signaling pathway controls transcriptional and cotranscriptional processes could provide new insights into the key functions of PI3K signaling in cancer. Here, we undertook a transcriptomic approach to investigate genome-wide gene expression and transcription factor activity changes, as well as splicing and isoform usage dynamics, downstream of PI3K. These analyses uncovered widespread alternatively spliced isoforms linked to proliferation, metabolism, and splicing in PIK3CA-mutant cells, which were reversed by inhibition of PI3Kα. Analysis of paired tumor biopsies from patients with PIK3CA-mutated breast cancer undergoing treatment with PI3Kα inhibitors identified widespread splicing alterations that affect specific isoforms in common with the preclinical models, and these alterations, namely PTK2/FRNK and AFMID isoforms, were validated as functional drivers of cancer cell growth or migration. Mechanistically, isoform-specific splicing factors mediated PI3K-dependent RNA splicing. Treatment with splicing inhibitors rendered breast cancer cells more sensitive to the PI3Kα inhibitor alpelisib, resulting in greater growth inhibition than alpelisib alone. This study provides the first comprehensive analysis of widespread splicing alterations driven by oncogenic PI3K in breast cancer. The atlas of PI3K-mediated splicing programs establishes a key role for the PI3K pathway in regulating splicing, opening new avenues for exploiting PI3K signaling as a therapeutic vulnerability in breast cancer.&lt;/p&gt;Significance:&lt;p&gt;Transcriptomic analysis reveals a key role for the PI3K pathway in regulating RNA splicing, uncovering new mechanisms by which PI3K regulates proliferation and metabolism in breast cancer.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/clincancerres/article/doi/10.1158/0008-5472.CAN-22-1466" target="_blank"&gt;See related commentary by Claridge and Hopkins, p. 2216&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Watch the interview with Eneda Toska, PhD, recipient of the 2023 Cancer Research Early Career Award: &lt;a href="https://vimeo.com/847434965" target="_blank"&gt;https://vimeo.com/847434965&lt;/a&gt;&lt;/p&gt;&lt;/div&gt;
Optimal printed wiring board design for high I/O density chip size packages (1999)

This paper addresses the issues involved in the design of high‐density boards for high‐density chip scale packages. An analytical model is developed to calculate the number of I/Os accommodated by the printed wiring board. The model is placed under constraints of package area, package I/O pitch, number of lanes per channel, PWB device feature sizes (I/O, via pad, signal traces), number of routing layers on board and the partition of routing regions on each level. The model is utilized to study the precise impact of number of routing layers and device feature size on the I/O density of PCB. The scheme for optimally partitioning each layer to achieve maximum I/O density is discussed. Specific guidelines are provided pertaining to the usage of higher board layers and/or reduced device feature sizes to design high‐density boards for future electronic products.
Intertemporal Competitive Equilibrium: An Empirical Study of Speculation (1977)

Theory and hypotheses, 600.—Subjects and experimental design, 601.—Experimental results, 605.—Concluding remarks, 610.—Appendix 1: Instructions for market experiment 1, 610.—Appendix 2: Instructions, 615.—Appendix 3: Subject index and limit prices, 618.—Appendix 4: Contracts in experiment 1, and bids, offers, and contracts for experiment 2, 619.
Simulation and modeling of data acquisition systems for future high energy physics experiments (1991)

The authors describe work undertaken at Fermilab in which several sophisticated tools have been brought together to provide an integrated systems engineering environment specifically aimed at designing data acquisition systems. Results of simulation experiments in which the effects of varying trigger rates, event sizes, and event distributions, over processors are clearly seen in terms of throughput and buffer usage in an event-building switch are also presented. In the context of the switch-based data acquisition system, it was possible to identify potential bottlenecks, determine buffer depths, aid system diagnosis, and better understand the interaction between different subunits as well as the system as a whole.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optogenetic Mouse Behavioral Modulation (2015)

Optogenetic stimulation of the right motor cortex in a Thy1-ChR2-EYFP transgenic mouse with 20Hz blue light flashes. Recorded July 14, 2007. Deisseroth Lab.
Ein Multitarget‐Gold(I)‐Komplex induziert Zytotoxizität im Zusammenhang mit Aneuploidie in HCT‐116‐Kolorektalkarzinomzellen (2020)

Abstract Ein neuartiger Alkinylphosphan‐Gold(I)‐Komplex – (Trimethylphosphan)(3‐(1,3‐dimethylxanthin‐7‐yl)prop‐1‐in‐1‐yl)gold(I) ( 1 ) – zeigte eine Vielzahl biologischer Aktivitäten, darunter selektive proliferationshemmende, antimetastatische und antiangiogene Wirkungen. In HCT‐116‐Kolonkarzinomzellen induzierte der Komplex zudem mit Aneuploidie in Zusammenhang stehende Effekte, die hauptsächlich auf die Dysfunktion der mitochondrialen Bioenergetik und die Herunterregulierung der Glykolyse zurückgeführt werden konnten. Die Induktion von Aneuploidie über ein kritisches Maß hinaus kann eine wirksame Strategie zur Bekämpfung von Krebs darstellen, besonders bei kolorektalen Tumoren mit einer geringen Toleranz für Aneuploidie. Dies könnte für 1 und andere Metallwirkstoffe von Bedeutung sein.
Optically Transparent Cathode for Co(III/II) Mediated Dye-Sensitized Solar Cells Based on Graphene Oxide (2012)

Thin semitransparent films were fabricated on F-doped SnO(2) (FTO) from single-layer graphene oxide (GO) either pure or in a composite with graphene nanoplatelets. Electrocatalytic activity of prepared films was tested for the Co(bpy)(3)(3+/2+) redox couple in acetonitrile electrolyte solution. Pristine GO showed almost no activity, resembling the properties of basal plane pyrolytic graphite. However, electrochemical performance of graphene oxide improved dramatically upon chemical reduction with hydrazine and/or heat treatment. All GO-containing films were firmly bonded to FTO, which contrasted with the poor adhesion of sole graphene nanoplatelets to this support. The activity loss during long-term aging was considerably improved, too. Enhanced stability of GO-containing films together with high electrocatalytic activity is beneficial for application in a new generation of dye-sensitized solar cells employing Co(bpy)(3)(3+/2+) as the redox shuttle.
Design and demonstration of tunable soft x-ray lateral shearing and Hartmann wavefront sensors (2018)

We describe design guidelines for soft x-ray wavefront sensors and experimentally demonstrate their performance, comparing grating-based lateral shearing interferometry and Hartmann wavefront sensing. We created a compact shearing interferometer concept with a dense array of binary amplitude gratings in a single membrane to support one-dimensional wavefront measurements across a wide wavelength range without the need for longitudinal position adjustment. We find that a common scaling parameter based on wavelength and the distance to the measurement plane guides the design of both systems toward optimal sensitivity. We show preliminary results from recent experiments demonstrating one and two-dimensional wavefront sensing below the Marechal criterion.
System-Level Assessment of Non-Orthogonal Spectrum Sharing via Transmit Beamforming (2013)

We assess the system-level performance of non-orthogonal spectrum sharing achieved via maximum sum-rate (SR), Nash bargaining (NB), and zero-forcing (ZF) transmit beamforming techniques. A look-up table based physical layer abstraction and radio resource management mechanisms (including packet scheduling) are proposed and incorporated in system-level simulations, jointly with other important aspects of network operation. In the simulated scenarios, the results show similar system-level performance of SR (or NB) as ZF in the context of spectrum sharing, when combined with maximum sum-rate (or proportional fair) packet scheduler. Further sensitivity analysis also shows similar behavior of all three beamforming techniques with regard to the impact on system-level performance of neighbor-cell activity level and feedback error. A more important observation from our results is that, under ideal conditions, the performance enhancement of non-orthogonal spectrum sharing over orthogonal spectrum sharing and fixed spectrum assignment is significant.
Regulation of the Skeletal Muscle Ryanodine Receptor/Ca2+-release Channel RyR1 by S-Palmitoylation (2014)

The ryanodine receptor/Ca(2+)-release channels (RyRs) of skeletal and cardiac muscle are essential for Ca(2+) release from the sarcoplasmic reticulum that mediates excitation-contraction coupling. It has been shown that RyR activity is regulated by dynamic post-translational modifications of Cys residues, in particular S-nitrosylation and S-oxidation. Here we show that the predominant form of RyR in skeletal muscle, RyR1, is subject to Cys-directed modification by S-palmitoylation. S-Palmitoylation targets 18 Cys within the N-terminal, cytoplasmic region of RyR1, which are clustered in multiple functional domains including those implicated in the activity-governing protein-protein interactions of RyR1 with the L-type Ca(2+) channel CaV1.1, calmodulin, and the FK506-binding protein FKBP12, as well as in "hot spot" regions containing sites of mutations implicated in malignant hyperthermia and central core disease. Eight of these Cys have been identified previously as subject to physiological S-nitrosylation or S-oxidation. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2+) release through RyR1. These findings demonstrate functional regulation of RyR1 by a previously unreported post-translational modification and indicate the potential for extensive Cys-based signaling cross-talk. In addition, we identify the sarco/endoplasmic reticular Ca(2+)-ATPase 1A and the α1S subunit of the L-type Ca(2+) channel CaV1.1 as S-palmitoylated proteins, indicating that S-palmitoylation may regulate all principal governors of Ca(2+) flux in skeletal muscle that mediates excitation-contraction coupling.