gebhart/patrepeval huggingface dataset:
Transanal Endoscopic Surgical Proctectomy for Proctitis Case Series Report: Diversion, Radiation, Ulcerative Colitis, and Crohnâ€™s Disease (2013)

Abstract: Background: With recent trends in natural orifice surgery, there has been a rising interest in the evolution of transanal endoscopic surgery (TES) and transanal access platforms. Transanal endoluminal removal of rectal masses has matured into transanal endoscopic surgical resection of the rectum for benign and malignant disease. The purpose of this study is to evaluate the surgical outcomes of TES completion proctectomy in patients with proctitis in a retained rectum. Methods: This is a retrospective case series report. Patient demographics and peri-operative outcome variables were recorded. Results: TES proctectomy was successfully performed in 6 patients using a disposable transanal access platform. The patient's ages ranged from 22 â€“ 74 years, 4 women and 2 men, BMI ranged from 22 â€“ 51 kg/m2. The indication for surgery was proctitis in a retained rectum: diversion (n=1), radiation (n=1), ulcerative colitis (n=2), and Crohn's disease (n=2). Four applications of TES proctectomy were employed: TES completion proctectomy (n=2), TES assisted single incision abdominal perineal resection (n=1), TES assisted laparoscopic restorative proctectomy with colo-anal anastomosis (n=1), and TES assisted laparoscopic restorative total proctocolectomy with ileal pouch anal anastomosis (n=1). The operative time for TES completion proctectomy ranged from 140 â€“ 238 minutes (n=4). The operative time for TES restorative proctectomy was longer at 446 min and 557 min (n=2). The hospital length of stay for both TES completion and restorative proctectomy ranged from 2 â€“ 5 days (n=5). Complications included 1 urinary tract infection, 1 chronic draining perineal sinus tract, and 1 perineal wound dehiscence requiring re-operation. All six patients are doing well at the time of follow up (range 3 â€“ 19 months). Conclusions: TES completion proctectomy alone or in combination with laparoscopic abdominal surgery is a safe and effective method to perform proctectomy and restorative proctectomy in this small case series of patients with proctitis in a retained rectum due to diversion, radiation, ulcerative colitis, and Crohn's disease.
The SeQuent™ Please drug-coated balloon system for percutaneous transluminal coronary angioplasty (2011)

Endovascular therapy for treatment of arterial obstructions has emerged as one of the most promising techniques in minimally invasive medicine during the last few decades. However, long-term outcome remains an area of concern in many applications. Drug-coated balloons represent an enhancement of the therapeutic repertoire for the interventional cardiologists. Among drug-coated balloons currently available on the market is the the SeQuent™ Please device, a coronary balloon catheter that combines balloon angioplasty with local delivery of paclitaxel. In several small, but randomized, clinical trials, the paclitaxel-coated SeQuent Please balloon catheter system has been shown to be safe and effective in reducing restenosis in patients with coronary in-stent restenosis, indicating that restenosis inhibition by immediate drug release is feasible. This article reviews the rationale for the use of paclitaxel-coated balloons, along with a focus on the SeQuent Please with its concept and the currently available cl...
Ultrasensitive Doppler based neuronavigation system for preclinical brain imaging applications (2016)

Ultrasensitive Doppler is a recent medical imaging technique enabling high sensitive acquisition of blood flows which can detect small vascular features without contrast agents. Applied to cerebral imaging of rodents, this method produces very fine vascular maps of the brain at high spatial resolution and leads to functional imaging of brain neuronal activity. These vascular networks contain crucial information about organs structure, and could be used as landmarks to 3D navigate the brain and register external atlas to the data. This study investigates a first step using a 2D correlation-based method to locate in real time young rat, rat, or mouse brain vascular prints in a 3D functional brain atlas.
ChemInform Abstract: Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of Carbocyclic 1‐(2′‐Deoxy‐6′‐fluororibofuranosyl)‐5‐iodouracils. (1987)

Abstract The azido alcohol (V), prepared from the optically active cyclohexenol (I), is transformed into the deoxyfluorouridines (X) and (XII) as outlined in the reaction scheme.
Abstract 13086: Defects in EphA2 Signaling Impair the Migration of Old Human Cardiac Stem Cells (2013)

Polina Goichberg, 2013 Finalist and Presenting Author
Laterally modulated 2D electron systems in the extreme quantum limit. (2004)

We report on magnetotransport of a two-dimensional electron system (2DES), located 32 nm below the surface, with a surface superlattice gate structure of periodicity 39 nm imposing a periodic modulation of its potential. For low Landau level fillings , the diagonal resistivity displays a rich pattern of fluctuations, even though the disorder dominates over the periodic modulation. Theoretical arguments based on the combined effects of the long-wavelength, strong disorder and the shortwavelength, weak periodic modulation present in the 2DES qualitatively explain the data.
Effect of [(CH2NH)4,5]secretin on pancreatic exocrine secretion in guinea pigs and rats (1993)

[psi 4,5]Secretin was shown to be a secretin receptor antagonist that inhibits secretin-stimulated increase in adenosine 3',5'-cyclic monophosphate in isolated pancreatic acini of the guinea pig. To determine whether it inhibits pancreatic exocrine secretion in vivo, we have studied the effect of [psi 4,5]secretin on the pancreatic secretion stimulated by secretin in anesthetized guinea pigs and rats. In basal state, [psi 4,5]secretin given intravenously for 2 or 3 h in varying doses of 1.6-32.7 nmol.kg-1.h-1 dose dependently increased pancreatic secretion of both fluid and bicarbonate during the 1st h, but it returned gradually to basal level within 2 or 3 h. On the other hand, [psi 4,5]secretin significantly inhibited the pancreatic secretion stimulated by either exogenous or endogenous secretin in a dose-related manner. The inhibitory effect of [psi 4,5]secretin in guinea pigs was greater than that in rats. However, it did not completely block the secretin-stimulated pancreatic secretion, whereas a rabbit antisecretin serum suppressed it completely. We conclude that 1) in the unstimulated state, [psi 4,5]secretin is a partial agonist of pancreatic exocrine secretion of both fluid and bicarbonate; and 2) when pancreatic secretion is stimulated by secretin, unlike an antisecretin serum, it is a partial inhibitor in intact guinea pigs and rats.
Inelastic strain birefringence in optical fibers (2006)

Retardation data captured by polarimetric stress-measurements in optical fibers have been reinterpreted in terms of both stress and inelastic strain. The linear dependence of strain birefringence on fiber drawing tension defines the Kohlrausch-Williams-Watt exponent
Recovering the Green’s function from field-field correlations in an open scattering medium (L) (2003)

The possibility of recovering the Green’s function from the field-field correlations of coda waves in an open multiple scattering medium is investigated. The argument is based on fundamental symmetries of reciprocity, time-reversal invariance, and the Helmholtz–Kirchhoff theorem. A criterion is defined, indicating how sources should be placed inside an open medium in order to recover the Green’s function between two passive receivers. The case of noise sources is also discussed. Numerical experiments of ultrasonic wave propagation in a multiple scattering medium are presented to support the argument.
Nocardia aobensis Sp. Nov., Isolated from Patients in Japan (2004)

Five clinical isolates, strains IFM 0137, 0372(T), 0496, 0556, and 0952, were provisionally assigned to the genus Nocardia based on morphological criteria. Nearly complete 16S rDNA sequences were determined for these strains. These data showed that they are most similar to that of Nocardia africana, Nocardia cerradoensis and Nocardia veterana. However, DNA-DNA relatedness data showed that the five strains were of a single species and were distinguishable from N. africana, N. cerradoensis and N. veterana. Therefore, these strains represent a new species within the genus Nocardia. The designation of these five strains is Nocardia aobensis sp. nov. The type strain is IFM 0372(T) (=NBRC 100429(T)=JCM 12352(T)=DSM 44805(T)).
Assessment of Acid Phosphatase Production by In vitro Cultures of Atropa acuminata (2016)

The potential of various culture lines of Atropa acuminata were investigated for resourcing acid phosphatase (ACP) (3.1.3.2). Crude enzyme extract comprised of a mixture of four isoforms, distinguishable by polyacrylamide gel electrophoresis (PAGE) with molecular weight ranging from 39 to 215 kDa. In vitro regenerated proliferative shoots, callus and roots showed higher specific activity (2.49, 3.41, 2.91 U/mg protein, respectively) as compared to in vivo grown plants (0.71 U/mg protein). ACP activity in root cultures increased progressively up to 4.6 U/mg during the entire growth period (2 ? 24 weeks), whereas in case of shoot cultures, the specific activity escalated to 2.49 U/mg at 8 weeks, which then declined subsequently (1.95 U/mg). Similarly, callus cultures initially showed a higher phosphohydrolytic activity (3.41 U/mg protein) until 8 weeks by which period, it decreased with the passage of growth period. The present studies reveal an alternate system for resourcing of ACP from Atropa acuminata.Plant Tissue Cult. &amp; Biotech. 26(1): 15-23, 2016 (June)
The Effect of Topical Delivery of Novel Bisacylphosphonates in Reducing Alveolar Bone Loss in the Rat Model (2000)

We conclude that ISA-13-like alendronate is effective in reducing alveolar bone loss when delivered at surgical sites. Since ISA-13 is well absorbed through mucose tissues, we suggest that ISA-13 efficacy on reducing bone loss should be tested by its application on the mucosal tissue.
Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues (2021)

Site-selective protein-protein coupling has long been a goal of chemical biology research. In recent years, that goal has been realized to varying degrees through a number of techniques, including the use of tyrosinase-based coupling strategies. Early publications utilizing tyrosinase from &lt;i&gt;Agaricus bisporus&lt;/i&gt; showed the potential to convert tyrosine residues into &lt;i&gt;ortho&lt;/i&gt;-quinone functional groups, but this enzyme is challenging to produce recombinantly and suffers from some limitations in substrate scope. Initial screens of several tyrosinase candidates revealed that the tyrosinase from &lt;i&gt;Bacillus megaterium&lt;/i&gt; (megaTYR) as an enzyme that possesses a broad substrate tolerance. We use the expanded substrate preference as a starting point for protein design experiments and show that single point mutants of megaTYR are capable of activating tyrosine residues in various sequence contexts. We leverage this new tool to enable the construction of protein trimers via a charge-directed sequential activation of tyrosine residues (CDSAT).
Laser photoionization of phenothiazine in alcoholic and aqueous micellar solution. Electron transfer from triplet states to metal ion acceptors (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser photoionization of phenothiazine in alcoholic and aqueous micellar solution. Electron transfer from triplet states to metal ion acceptorsS. A. Alkaitis, G. Beck, and M. GraetzelCite this: J. Am. Chem. Soc. 1975, 97, 20, 5723–5729Publication Date (Print):October 1, 1975Publication History Published online1 May 2002Published inissue 1 October 1975https://pubs.acs.org/doi/10.1021/ja00853a015https://doi.org/10.1021/ja00853a015research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations186LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Table S6 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors (2023)

&lt;p&gt;Glioblastoma patient characteristics (DFCI)&lt;/p&gt;
Morphological changes (including filamentation) in Escherichia coli grown under starvation conditions on silicon wafers and other surfaces (1999)

Using a scanning electron microscope, pleomorphism (notably filamentation) was seen when Escherichia coli was grown under starvation conditions for 14 d on microporous silicon wafers, titanium, glass and plastic discs. Under these conditions, the 'standard', rod shaped cell (1-3 microns) failed to separate after division and filaments developed, some as long as 50 microns, with many showing bulbous tips. Filamentation began to occur 5 d after the imposition of starvation conditions. Dumbbell shaped cells were also observed, although apparent 'Y' and 'V'-shaped cells proved to be artefacts, caused by overlapping rods. The implications of the appearance of pleomorphism in E. coli, when grown under starvation conditions, is discussed in relation to its pathogenicity and growth in the environment.
Mixing Realities at Ismar 2009: Scary and Wondrous (2010)

The Eighth IEEE International Symposium on Mixed and Augmented Reality (Ismar 2009) combined a traditional science-and-technology track with an art, media, and humanities track to provide a nontraditional cross-disciplinary view of an increasingly important and growing research area.
Assessing the human immune system through blood transcriptomics (2010)

Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed.
ChemInform Abstract: Heterogeneous Catalysts for the One‐Pot Synthesis of Chemicals and Fine Chemicals (2011)

Abstract Review: 558 refs.
Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex. (1980)

The resolved pyruvate dehydrogenase component is a tetramer containing two (Y subunits and two p subunits.It is assumed that in an a& tetramer, there are two catalytical units, i.e. one per a@ unit.This is consistent with previous studies (9) indicating one T P P or one TTPP binding site per ap unit.
Community-Level Access Divides (2016)

Despite the appearance of uniform availability of mobile services, in many locales granular network analyses reveal the persistence of physical access divides. It stands to reason these divides, similar to those at larger scales, are also reflections of community-level social and economic divides.
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. (1987)

KB cells respond to insulin and insulin-like growth factor I (IGF-I) in a closely similar way (induction of membrane ruffling, stimulation of pinocytosis, and amino acid transport) but respond to epidermal growth factors (EGF) in a similar but distinct way. In the KB cells, using phosphotyrosine-specific antibody we have found that: the receptors for insulin (beta subunit), IGF-I (beta subunit), and EGF undergo tyrosine phosphorylation as early as 10 s after addition of their respective ligands; a 185-kDa protein is rapidly (less than 10 s) tyrosine phosphorylated by insulin and IGF-I through their respective receptor kinases but not EGF; tyrosine phosphorylation of a 190-kDa glycoprotein is rapidly (less than 10 s) induced by EGF through EGF receptor kinase; and tyrosine phosphorylation of a 240-kDa protein is stimulated within 30 s by all three growth factors. These patterns of tyrosine phosphorylation could be causally related to biological responses induced by the three growth factors.
Causal Analysis for Robust Interpretability of Neural Networks (2023)

Interpreting the inner function of neural networks is crucial for the trustworthy development and deployment of these black-box models. Prior interpretability methods focus on correlation-based measures to attribute model decisions to individual examples. However, these measures are susceptible to noise and spurious correlations encoded in the model during the training phase (e.g., biased inputs, model overfitting, or misspecification). Moreover, this process has proven to result in noisy and unstable attributions that prevent any transparent understanding of the model's behavior. In this paper, we develop a robust interventional-based method grounded by causal analysis to capture cause-effect mechanisms in pre-trained neural networks and their relation to the prediction. Our novel approach relies on path interventions to infer the causal mechanisms within hidden layers and isolate relevant and necessary information (to model prediction), avoiding noisy ones. The result is task-specific causal explanatory graphs that can audit model behavior and express the actual causes underlying its performance. We apply our method to vision models trained on classification tasks. On image classification tasks, we provide extensive quantitative experiments to show that our approach can capture more stable and faithful explanations than standard attribution-based methods. Furthermore, the underlying causal graphs reveal the neural interactions in the model, making it a valuable tool in other applications (e.g., model repair).
Effects of metal contacts and dopants on the performance of ZnO-based memristive devices (2011)

We have performed a detailed investigation of the fabrication and switching characteristics of ZnO-based memristive devices. The effects of doping and various metal contacts have been studied. It is observed that, with the use of Al metal contacts and ZnO:Al layers, relatively high ROFF/RON ratios of 200 can be achieved. Much improved device stability and reproducibility, on the other hand, can be realized by using either nominally undoped or Mg-doped ZnO memristive layers. The experimental results may be well explained by an oxygen vacancy formation and migration model. The present work represents an important step in realizing high performance ZnO-based memristive devices for future nonvolatile memory applications.
Effector characteristics of the IgG3 murine monoclonal antibody 113F1. (1989)

Successful immunotherapy with unconjugated murine monoclonal antibodies (MAbs) is likely to require antibodies with potent effector characteristics such as antibody-dependent cellular cytotoxicity (ADCC). The newly developed IgG3 isotype antibody, 113F1, binds to a target antigen present in high copy number on SK-Br-3 cell surfaces. 113F1 does not appear to participate in complement-mediated cytotoxicity, but is a potent mediator of ADCC by human monocytes directed against a variety of malignant cell lines expressing 113F1's target antigen. Although recombinant interleukin-2 (rIL-2) promotes nonspecific monocyte cytotoxicity, preincubation with this cytokine has no effect on monocyte ADCC in our system. 113F1 promotes ADCC by nonadherent cells expressing lymphokine-activated killer (LAK) activity following incubation of these cells in rIL-2. These latter effects are abrogated by Fc receptor blockade prior to addition of 113F1. 113F1 is a more potent mediator of ADCC by monocytes or LAK cells than is 17-1A, an extensively tested unconjugated murine IgG2a isotope MAb. These data suggest that unconjugated 113F1 MAb immunotherapy trials should investigate treatment with the MAb alone. In addition, 113F1 could be administered with rIL-2, either alone or supplemented with infusions of autologous LAK cells.
Laboratory evaluation on the potential of entomopathogenic fungi, Nomuraea rileyi against tobacco caterpillar, Spodoptera litura Fabricius (Noctuidae: Lepidoptera) and its safety to Trichogramma sp. (2010)

Tobacco caterpillar, Spodoptera litura was reared in semi-synthetic diet and the different stages were maintained for bioassay. Entomopathogenic fungi, Nomuraea rileyi was sub-cultured using Potato Dextrose Agar (PDA). Spore suspensions of four different concentrations (2.4 × 10, 2.4 × 10 and 2.4 × 10, 2.4 × 10 conidia/ml) were prepared from the 15 day old culture of the fungi for evaluation. A preliminary study on N. rileyi against S. litura larvae was done. Cypermethrin 25 EC, Neem Plus and untreated were used as controls. Though the pupation was not suppressed as expected, the pupal weight, length and duration were severely affected. The malformed adults were the highest (96.7%) in pupae treated with 2.4 × 10 spore concentration. Subsequently, the fecundity was completely arrested in N. rileyi at 2.4 × 10, 2.4 × 10and 2.4 × 10 spore conc. The biosafety of N. rileyi against Trichogramma japonicum and Trichogramma chilonis was confirmed by monitoring the parasitization and male-female ratio and proved that the N. rileyi was safe to these egg parasitoids.