gebhart/patrepeval huggingface dataset:
Intraoperative Radiotherapy in Retroperitoneal Sarcomas (1993)

Thirty-five patients with surgically resected sarcomas of the retroperitoneum were enrolled in a prospective, randomized, clinical trial comparing 20-Gy intraoperative radiotherapy in combination with postoperative low-dose (35- to 40-Gy) external-beam radiotherapy with postoperative high-dose (50- to 55-Gy) external-beam radiotherapy alone. Chemotherapy with doxorubicin hydrochloride, cyclophosphamide (anhydrous), and methotrexate sodium was used for a portion of the trial. Fifteen patients who received intraoperative radiotherapy and 20 control patients were followed up for a minimum of 5 years (median follow-up, 8 years). Median survival times were similar for the group that received intraoperative radiotherapy (45 months) and the control group (52 months). There were no indications of benefit from adjunctive chemotherapy. The number of locoregional recurrences was significantly lower among those who received intraoperative radiotherapy (six of 15) than control patients (16 of 20). Patients who received intraoperative radiotherapy had fewer complications of disabling radiation-related enteritis (two of 15) than control patients (10 of 20), but radiation-related peripheral neuropathy was more frequent among those who received intraoperative radiotherapy (nine of 15) than among control patients (one of 20).
Use of a Two-Class Model to Analyze Applications and Barriers to the Use of Virtual Reality by People with Disabilities (1994)

In analyzing virtual reality applications to examine access issues for people with disabilities, it is useful to separate those applications where the virtual reality (VR) presentation is used as a metaphor from those where the mode of presentation is inherently tied to, or restricted by, the information being presented. In the case where VR is being used only as a metaphor, it is often possible to provide access even to individuals with severe physical, cognitive, and sensory impairments by providing a display/control via an alternate mechanism in parallel with the VR metaphor. This type of parallel display/control strategy is not available when the presentation is inherently tied to the information being presented. For both types of applications, however, the application of virtual altered realities (VAR) can be used to either transpose or enhance the presentation of information in order to facilitate its perception and manipulation by people with varying physical, cognitive, and sensory abilities. This paper presents the strategies underlying these two approaches as well as providing examples of ways the strategies can be used to increase the accessibility and useability of virtual reality by people with disabilities.
CellProfiler Analyst: data exploration and analysis software for complex image-based screens (2008)

The system enables interactive data exploration for image-based screens and automated scoring of complex phenotypes that require combinations of multiple measured features per cell.
A Comparative Study of Ultrasonic Pretreatment and an Internal Recycle for the Enhancement of Mesophilic Anaerobic Digestion (2009)

The objective of this study was to investigate the use of ultrasonic energy in an internal recycle and pretreatment mode of operation relative to a conventional mode of mesophilic anaerobic digestion. The primary focus was to determine if using ultrasonics in a pretreatment mode and in an internal recycle line produced changes in performance relative to each other and the control. Using a relatively low-energy sonication system, the data showed that the addition of ultrasonic energy, in either a recycle line or as a pretreatment technology, improved anaerobic digestion efficiency for waste-activated sludge. There was a 13 to 21% increase in biogas yield and an increase in total and volatile solids destruction of 3 to 10.3 additional percentage points, depending on the ultrasonic dose and location. Dewatering of the biosolids following ultrasonic treatment was poorer, as measured by an increase in the optimum polymer conditioning dose. The addition of ultrasonics to the digestion systems generated a more stable biosolids product, with a 2 to 58% reduction in organo-sulfur gas production from dewatered biosolids cakes.
Is fasting leptin associated with insulin resistance among nondiabetic individuals? The Miami Community Health Study. (1999)

Cross-sectionally, leptin was significantly associated with insulin resistance in this nondiabetic sample of men and women. There may be a different physiological mechanism to explain the leptin/insulin resistance association apart from the insulin/adiposity link. Confirmatory evidence awaits the results of clinical trials.
Tailored gas-absorbing materials for packaged opto-electronic devices (2023)

Recently special gas-adsorbing materials have been developed to capture gaseous contaminants such as moisture, organics and hydrogen in Optical Transceivers, multiplexers, and laser diodes that otherwise may be detrimentally affected by these gases. Hermetically sealed, or semi-hermetic packages are often used to protect High-Reliability Opto-electronic devices from possible damages due to atmospheric gases and harsh environment, aiming for higher performances and longer lifetime of the modules. Nevertheless, sealed devices may experience issues from internal outgassing of gas species like H2O, H2, and VOCs (Volatile Organic Compounds) released by inner materials or components. As reported in MIL-STD-883, the moisture limit of 5,000 ppm is specified as the critical concentration for which evident corrosion mechanisms are observed in integrated circuits and hybrid components. Moisture can be a problem in several PIC (Photonic Integrated Circuits) devices. It is also known that moisture and hydrogen may have negative effects in High Speed Optical Transceivers or that VOCs may cause problems in Laser Diode modules. Special Getter Materials integrated in the packages – especially in their lids – can successfully fix these issues. New getter materials have been developed to sorb the detrimental gases. In particular they have been designed to cope with MIL requirement for moisture and to ensure very low water concentration, even well below 1,000 ppm. Depending on the device and on the amounts of detrimental gases to be sorbed the getter can be selected and properly sized. It is usually activated by heating in vacuum or nitrogen, immediately before the sealing of the device package.
The Laparoscopic Monti Procedure for Long Strictures of the Proximal Ureter: A Novel Technique (2004)

No AccessJournal of UrologyUrological Survey: Abstracts: Urolithiasis, Endourology and Laparoscopy1 Nov 2004The Laparoscopic Monti Procedure for Long Strictures of the Proximal Ureter: A Novel Technique Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)60976-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "The Laparoscopic Monti Procedure for Long Strictures of the Proximal Ureter: A Novel Technique." The Journal of Urology, 172(5), p. 2106 References 1 : Bridging long ureteral defects using the Yang-Monti principle. J Urol2003; 169: 1074. Link, Google Scholar © 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 172Issue 5November 2004Page: 2106 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Development of Cancer Radioimmunotherapy and its Potential Use as an Adjuvant Treatment (2018)

This chapter suggests that radiolabeled antibodies can effectively localize and kill micrometastatic nodules of colon cancer. In addition, radioimmunotherapy (RAIT) has been shown to be superior to conventional chemotherapy in treating micrometastatic disease in this preclinical model, thereby supporting a potential role for this procedure as an adjuvant cancer treatment. Surgery is the most common treatment for solid tumors. If removed at an early stage of tumor development, the prognosis can be excellent. As with chemotherapy, there are many possible agents that can be selected for RAIT treatment. In addition, there are many parameters that influence an antibody's targeting ability and ultimately the success of RAIT. Although the pioneering investigators in the 1950s envisioned a future role for radiolabeled antibodies in cancer treatment, RAIT was not aggressively studied until the 1980s. Since adjuvant trials require monitoring time until disease recurrence or survival, a substantial patient population is required with appropriately matched controls.
Challenges in Scaling Analysis from Coupons to Elements in 3D Woven Composites for a Launch Vehicle End-Ring Structure (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-1006.vid The limitations of structural design with 3D woven composites based on homogenized material models characterized using coupon test data, representative unit cell analysis, or a combination of the two are discussed in the context of a space launch system (SLS)-scale end ring. Selected building block test configurations at the coupon, element, and subcomponent scales are described in detail. Highly instrumented tests and X-ray computed tomography inspections are used to characterize the structural behavior and associated damage progression with increasing load. It is shown that a single homogenized material constitutive relationship, applied at coupon and element scale, is not sufficient to model the structural response observed in both tests. In fact, substantially different stress-strain laws are required to predict the response of the coupon and element scale specimens, despite similar loading conditions. A model with discrete representation of the binder tows and cohesive interfaces to model matrix cracking shows much better agreement with the test data at the two length scales. Thus, evidence is provided showing that predictive structural analysis of 3D woven composites requires discrete representation of the tows, matrix cracking morphology, and their interactions in the structural configuration. With accurate knowledge of the element scale behavior, engineering approximations readily enable analysis scale-up to the subcomponent level.
Removal of Acrolein from Active Pharmaceutical Ingredients Using Aldehyde Scavengers (2012)

A variety of chemical compounds, intermediates, and reagents are used during the process of synthesizing active pharmaceutical ingredients (APIs). Some of these chemicals, intermediates, and reagents, as well as byproducts of synthetic processes, can have toxic properties and be present as impurities at low levels in the API or final drug formulation. If present at high concentrations, the toxic impurities could cause adverse health effects in humans. This paper describes a simple and rapid approach for selective removal of acrolein from APIs using iodixanol as a model API. Several scavengers were tested, and the resins which showed highest binding efficiency and selectivity were chosen for further evaluations. The kinetics of acrolein scavenging in the presence of the API iodixanol and the scavenging capacity of resins were demonstrated in this paper. The most complete scavenging is obtained with PS-NH2 which removes 97.8% of acrolein without any substantial removal of the API during 20 min of reaction time.
Micro pore arrays in free standing cyclic olefin copolymer membranes: fabrication and surface functionalization strategies for in-vitro barrier tissue models (2013)

In recent years there has been growing interest in micro engineered in-vitro models of tissues and organs. These models are designed to mimic the in-vivo like physiological conditions with a goal to study human physiology in an organ-specific context or to develop in-vitro disease models. One of the challenges in the development of these models is the formation of barrier tissues in which the permeability is controlled locally by the tissues cultured at the interface. In-vitro models of barrier tissues are typically created by generating a monolayer of cells grown on thin porous membranes. This paper reports a robust preparation method for free standing porous cyclic olefin copolymer (COC) membranes. We also demonstrate that gelatin coated membranes facilitate formation of highly confluent monolayer of HUVECs. Membranes with thickness in the range of 2-3 um incorporating micro pores with diameter approximately 20 um were fabricated and integrated with microfluidic channels. The performance of the device was demonstrated with a model system mimicking the endothelial barrier in bone marrow sinusoids.
Editorial for the special issue of Materials Horizons in honor of Seth Marder (2021)

Jean-Luc Brédas, Zhenan Bao, Thuc-Quyen Nguyen, and Mark E. Thompson introduce the Materials Horizons special issue in honor of Seth Marder.
Biomechanics of Patellofemoral Joint Prostheses (2005)

We describe the biomechanics of the patellofemoral joint and of patellofemoral joint prostheses. It seemed that the designs and associated instruments that were studied had little research and development and that soft tissue realignment procedures often were needed because of pre-existing pathology. Factors that help these unicompartmental implants to integrate with the surrounding knee structures are discussed, particularly articular geometry, contact areas, forces and fixation. The desirability of patellar area contact geometry rather than axisymmetric buttons with point or line contact is discussed, in relation to their use in younger more active patients. Bone preservation relating to revision to total knee arthroplasty also is considered. Data on the articular geometry, stability and tracking of the designs studied are presented, showing that although most parameters are returned within normal limits, problems such as erratic subluxation-reduction effects may occur if the patellar component catches on the edge of the femoral component during knee flexion-extension. Through our results, we suggest that further implant and instrumentation research and development are needed before clinical trials leading to widespread use.
Explaining the Increase of Diabetes Prevalence and Plasma Glucose in Mauritius (2011)

In Mauritius, there has been a marked increase in diabetes prevalence over 22 years. This mainly results from changes in traditional risk factors, leading to population-wide increases in plasma glucose levels. Interventions to control this escalation of diabetes should focus on population-wide strategies.
Low-Energy State Electron Beam in a Uniform Channel (2019)

In our earlier work, we showed that a low-energy state of an electron beam exists in a nonuniform channel between two virtual cathodes in a magnetron with diffraction output, which consists of three uniform sections with increasing radius. A uniform axial magnetic field fills the interaction space. This led to magnetron operation with &gt;90% efficiency when combined with a magnetic mirror field at the output end. In this present paper, we show that a low-energy state of an electron beam can be realized in a uniform channel in which an increasing magnetic field is used in order to create a magnetic mirror at the output end. We consider two cases, one where the injected beam current slightly exceeds the space-charge-limiting current and the other where the injected beam current greatly exceeds the space-charge-limiting current. On the time scale of relevance to planned experiments (∼30 ns), when the injected current slightly exceeds the space-charge-limiting current a stationary virtual cathode forms and when the injected current greatly exceeds the space-charge-limiting current the virtual cathode oscillates back and forth.
Kinetics and energetics of a fast polyurethane cure (1977)

Abstract Methods for obtaining kinetic data on bulk polymerizing systems are reviewed, and adiabatic temperature rise is found to be the most useful for fast systems. An adiabatic method is described and used to study the polymerization of poly(ε‐caprolactone triol) with chain‐extended 1,6‐hexane diisocyanate catalyzed with dibutyltin dilaurate.
ChemInform Abstract: REGIO‐ AND STEREOSELECTIVITY IN THE ENE REACTION OF N‐PHENYL‐1,2,4‐TRIAZOLINE‐3,5‐DIONE WITH α,β‐UNSATURATED CARBONYL SUBSTRATES (1981)

Abstract 4‐Phenyl‐triazolin (I) reagiert mit zahlreichen α,β‐ungesättigten Ketonen zu Addukten wie (III), (V), (VII), (IX) oder (XI), aus 2‐Methyl‐2‐cyclohexenon (XII) wird ein Bis‐Addukt (XIII) gebildet.
Enantio‐ and Diastereoselective Suzuki–Miyaura Coupling with Racemic Bicycles (2019)

Herein, we describe a rhodium-catalyzed enantio- and diastereoselective Suzuki-Miyaura cross-coupling between racemic fused bicyclic allylic chlorides and boronic acids. The highly stereoselective transformation allows for the coupling of aryl, heteroaryl, and alkenyl boronic acids and gives access to functionalized bicyclic cyclopentenes, which can be converted into other five-membered-ring scaffolds with up to five contiguous stereocenters. Preliminary mechanistic studies suggest that these reactions occur with overall retention of the relative stereochemistry and are enantioconvergent for pseudo-symmetric allylic chloride starting materials. In addition, a bicyclic allylic chloride starting material without pseudo-symmetry undergoes a highly enantioselective regiodivergent reaction.
Characterization of Vortex Flow in a Mouse Model of Ventricular Dyssynchrony by Plane-Wave Ultrasound Using Hexplex Processing (2020)

The rodent heart is frequently used to study human cardiovascular disease (CVD). Although advanced cardiovascular ultrasound imaging methods are available for human clinical practice, application of these techniques to small animals remains limited due to the temporal and spatial-resolution demands. Here, an ultrasound vector-flow workflow is demonstrated that enables visualization and quantification of the complex hemodynamics within the mouse heart. Wild type (WT) and fibroblast growth factor homologous factor 2 (FHF2)-deficient mice (Fhf2 <sup>KO/Y</sup> ), which present with hyperthermia-induced ECG abnormalities highly reminiscent of Brugada syndrome, were used as a mouse model of human CVD. An 18-MHz linear array was used to acquire high-speed (30 kHz), plane-wave data of the left ventricle (LV) while increasing core body temperature up to 41.5 °C. Hexplex (i.e., six output) processing of the raw data sets produced the output of vector-flow estimates (magnitude and phase); B-mode and color-Doppler images; Doppler spectrograms; and local time histories of vorticity and pericardium motion. Fhf2 <sup>WT/Y</sup> mice had repeatable beat-to-beat cardiac function, including vortex formation during diastole, at all temperatures. In contrast, Fhf2 <sup>KO/Y</sup> mice displayed dyssynchronous contractile motion that disrupted normal inflow vortex formation and impaired LV filling as temperature rose. The hexplex processing approach demonstrates the ability to visualize and quantify the interplay between hemodynamic and mechanical function in a mouse model of human CVD.
Characterization of transient error tolerance for a class of mobile embedded applications (2014)

We study the inherent resilience (to transient errors) of a class of embedded applications that are currently under study in the DARPA-sponsored program called PERFECT. The experimental setup used in this research uses a fast fault-injection methodology, that takes advantage of native execution speeds on actual system hardware. The reported resilience characterization data are interpreted in the context of measured workload metrics like dynamic instruction frequency mix.
Electromagnetic propulsion system (2023)

An electromagnetic propulsion system is provided. The system comprises first and second pluralities of stator coils wound about first and second axes, a plurality of support structures, first and second couplers that surround portions of the first and second pluralities of stator coils, and first and second pluralities of sets of rotor coils wound about axes that are parallel to the first and second axes. The stator coils are configured to receive electric current through an outside controller selecting appropriately coupled stator sections or through a sliding electrical contact system or bearing system to induce at least a first magnetic field. The plurality of support structures supports the first and second plurality of stator coils. The first and second couplers include notches and are oriented so that their notches pass over the plurality of support structures when the couplers move along the stator coils. The couplers may have an adjustable segment to close the notch. The sets of rotor coils are equidistantly attached to the couplers and are configured to receive electric current to induce magnetic fields that interact with the magnetic fields of the stator coils so that magnetic forces are applied to the plurality of rotor coils, thereby propelling the couplers along the stator coils.
Fig S2 from A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes (2023)

&lt;p&gt;Endosomal itinerary&lt;/p&gt;
New Trends in Satellite Communications (2009)

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Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1 (2019)

Abstract Inhibitors of PI3Kdelta are approved as monotherapy for the treatment of hematologic malignancies such as follicular B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Recent reports suggest that inhibition of PI3Kdelta in mice is effective against solid cancers as well. Mechanistic studies by several groups have suggested a possible adaptive immune-mediated anti-tumor response involving immunosuppressive Tregs and/or MDSCs in the tumor microenvironment. Our structure-guided discovery program led to the identification of a novel heterocycloalkyl purine inhibitor class with excellent isoform and kinome selectivity, as well as good solubility. Optimization included potency enhancements, addressing metabolism and increasing half-life in preclinical species to provide a PI3Kdelta inhibitor with a low once-daily predicted human dose. In FoxP3 reporter mice harboring MC38 tumors treated with inhibitor, we observed reduced peripheral Treg function and an increased ratio of CD8 to Treg in both spleen and tumor-infiltrating lymphocytes. In three-week efficacy studies, modest tumor growth inhibition was found in 4T1, MC38 and CT26 syngeneic tumor models when our inhibitor was dosed as a single agent and we demonstrated a trend towards better efficacy when our inhibitor was dosed in combination with an anti-mPD-1 antibody in CT26 tumor-bearing mice as compared to anti-mPD-1 alone. These preliminary studies confirm the impact of PI3Kdelta inhibition on T-cell subpopulations, and support continued exploration of PI3Kdelta inhibitors for the treatment of solid tumors, either as monotherapy or in combination with other agents. Citation Format: Joey L. Methot, Hua Zhou, Meredith A. McGowan, Benjamin W. Trotter, Michael Altman, Xavier Fradera, Charles Lesburg, Chaomin Li, Stephen Alves, Craig P. Chappell, Renu Jain, Ruban Mangado, Elaine Pinheiro, Sybil M. Williams, Peter Goldenblatt, Armetta D. Hill, Lynsey Shaffer, Dapeng Chen, Robbie L. McLeod, Hyun-Hee Lee, Sanjiv Shah, Jason D. Katz. Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2254.