gebhart/patrepeval huggingface dataset:
Aerial Platform placement algorithms to satisfy connectivity, capacity and survivability constraints in wireless ad-hoc networks (2008)

In this paper, we address the problem of establishing full connectivity and satisfying required traffic capacity between disconnected clusters in large wireless ad-hoc ground networks by placing a minimum number of advantaged high flying Aerial Platforms (APs) as relay nodes at appropriate places. We also extend the connectivity solution in order to make the network survivable to a single AP failure. The problem of providing both connectivity and required capacity between disconnected ground clusters is formulated as a summation-form clustering problem with inter-AP distance constraints that make the AP network fully connected and with complexity costs that take care of cluster to AP capacity constraints. The resultant clustering problem is solved using deterministic annealing to find (near) globally optimal solutions for the minimum number and locations of the APs to establish full connectivity and provide required traffic capacity between disconnected clusters. In order to make the network single AP survivable, the connectivity solution is extended so that each AP connects to at least two neighboring APs and each ground cluster connects to at least two APs. We establish the validity of our algorithms by comparing it with optimal exhaustive search algorithms and show that our algorithms are near-optimal for the problem of establishing connectivity between disconnected clusters.
Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis (2021)

In patients with compensated cirrhosis due to NASH, regression of fibrosis is associated with a reduction in liver-related complications. These data support the utility of histologic fibrosis regression and NITs as clinical trial endpoints for NASH cirrhosis.
The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo (2015)

From these findings we conclude that both analogs are promising agents for the development of antiangiogenic drugs acting independent on classical inhibition of VEGF signaling.
Supplementary Figure 5 from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus (2023)

Supplementary Figure 5 from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
Training of neural networks to perform optical performance monitoring of a combination of accumulated signal nonlinearity, CD, PMD, and OSNR (2008)

We propose a technique using artificial neural networks to simultaneously identify fiber nonlinearity, OSNR, CD, and PMD from eye-diagram and eye-histogram parameters. A correlation coefficient of 0.97 is obtained for a set of testing data.
A Low-Cost Bench for Training Students in Power Amplifier and Digital Predistortion (2023)

This paper presents a low-cost bench to provide a comprehensive set of measurement capabilities to train students in RF Integrated Circuits characterization and their enhancement with a focus on Power Amplifier (PA) and its associated Digital Predistortion (DPD). It brings into play two Universal Software Radio Peripherals (USRP) and a user-friendly interface to perform measurements on a radio-frequency (RF) chain and to extract circuit characteristics. The interface was designed on MATLAB App Designer to provide students with an ergonomic and pedagogical user experience. Additionally, DPD software was designed for students to evaluate various PA linearization models and benchmark their performances. Furthermore, students can use this bench to test and validate their own circuit designs, providing hands-on experience and helping them to gain a better understanding of the principles of RF design. Finally, a survey displays feedback on students’ pedagogical appreciation of the bench.
Genetics of Dizygotic Twinning: A Feasibility Study for a Biobank (2004)

To locate the genes that make a substantial contribution to variation in natural dizygotic twinning in humans, large-scale studies are needed. New studies should not stop at DNA genotyping, but collect material that allow gene-expression analysis, transcriptomics, proteomics and endocrinology. In this article we describe a pilot study to examine the feasibility, effectiveness and logistics of large-scale nationwide sample collection in Dutch families in which two or more sisters have given birth to spontaneous dizygotic twins. Pedigree data and addresses from family members of proband mothers were collected by telephone. Blood and urine samples were collected during a home visit, and handled in the afternoon. All participants were bled between 7 a.m. and 10 a.m. after overnight fasting. Blood samples of fertile women with a natural cycle were collected on the second, third or fourth day of their menstrual cycle. The effects of transportation and storage on blood quality, lipids, RNA with and without challenge, lymphocytes and other parameters were examined. Genomic DNA was isolated from blood and cells were immortalized using Epstein-Barr virus. In 78.6% of the women with a natural cycle blood samples were collected on the second, third or fourth day of the menstrual cycle. This percentage is likely to increase with the more dense geographical distribution of participants in the larger population. We conclude that the pilot study demonstrated the feasibility of this protocol to collect good quality of plasma, DNA, RNA and lymphocyte samples by home visits.
Hedgehog signaling sensitizes Glioma stem cells to endogenous nano-irradiation (2014)

The existence of therapy resistant glioma stem cells is responsible for the high recurrence rate and incurability of glioblastomas. The Hedgehog pathway activity plays an essential role for self-renewal capacity and survival of glioma stem cells. We examined the potential of the Sonic hedgehog ligand for sensitizing of glioma stem cells to endogenous nano-irradiation. We demonstrate that the Sonic hedgehog ligand preferentially and efficiently activats glioma stem cells to enter the radiation sensitive G2/M phase. Concomitant inhibition of de novo thymidine synthesis with fluorodeoxyuridine and treatment with the Auger electron emitting thymidine analogue 5-[I-125]-Iodo-4â²-thio-2â²-deoxyuridine ([I-125]ITdU) leads to a fatal nano-irradiation in sensitized glioma stem cells. Targeting of proliferating glioma stem cells with DNA-incorporated [I-125]ITdU efficiently invokes the intrinsic apoptotic pathway despite active DNA repair mechanisms. Further, [I-125]ITdU completely inhibits survival of glioma stem cells in vitro. Analysis of non-stem glioblastoma cells and normal human astrocytes reveals that glioma stem cells differentially respond to Sonic hedgehog ligand. These data demonstrate a highly efficient and controllable single-cell kill therapeutic model for targeting glioma stem cells.
Microarea analysis of iron and phosphorus by resonance photoionization sputtered neutral mass spectrometry (2007)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation H. Shichi, S. Osabe, M. Sugaya, K. Kanehori, H. Kakibayashi, Y. Mitsui; Microarea analysis of iron and phosphorus by resonance photoionization sputtered neutral mass spectrometry. Journal of Vacuum Science & Technology A 1 July 2007; 25 (4): 751–757. https://doi.org/10.1116/1.2746048 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Integrated 100 W thulium fiber MOPA system (2012)

We have developed an integrated Tm:fiber master oscillator power amplifier (MOPA) system producing 100 W output power, with sub-nm spectral linewidth at -10 dB level, &gt;10 dB polarization extinction ratio, and diffraction-limited beam quality. This system consists of polarization maintaining fiber, spliced together with fiberized pump combiners, isolators and mode field adaptors. Recent advances in PM fibers and components in the 2 &mu;m wavelength regime have enabled the performance of this integrated high power system; however further development is still required to provide polarized output approaching kilowatt average power.
New Inkjet Solution for Direct Printing of Local Diffusion Barriers on Solar Cells (2008)

The realization of high-efficiency silicon solar cell designs like rear contacts, local back surface fields or selective emitters in industrial solar cell production, depends on the existence of cost-effective processing techniques. This report introduces the inkjet-ready isishape SolarResistTM diffusion barrier solution. It can be used to directly print diffusion barrier layers for the local formation of highly-doped regions without additional structuring. Thin films of 190 nm thickness work as a barrier against industrially relevant phosphorus diffusions. No adverse effect on the charge carrier lifetime is observed. Printed line widths of 90 μm are achieved, and the minimum gap width between lines is 50 μm.
Extending The Folksonomies Of Freesound.Org Using Content-Based Audio Analysis (2009)

(Abstract to follow)
Overlay budget considerations for an all-scanner fab (2000)

According to the SIA roadmap an overlay of 65nm is necessary for state of the art 0.18micrometers processes. To meet such tight requirements it is necessary to know the magnitude of all contributions, to understand possible interactions and to try to drive every individual overlay component to its ultimate lower limit. In this experimental study we evaluate the impact of different contributions on the overall overlay performance in a fab equipped exclusively with ASML step and scan systems. First we discuss the overlay performance of advanced step and scan systems in a mix and match scenario, focusing on single machine overlay, long term stability and multiple machine matching. We show that both distortion and stage differences between different tools are typically less than 22nm, justifying a multiple machine scenario without significant loss of overlay performance. In the next step, we discuss the impact of layer deposition and CMP. We include shallow trench isolation, tungsten-CMP as well as conventional aluminum wiring and copper-dual-damascene technology into our examinations. In particular, we discuss the pro's and con's of using a zero-layer-mark-approach, compared to an alignment on marks formed in certain layers for direct layer to layer alignment. Furthermore, we examine the performance of ASMLs 'through-the-lens' (TTL)-alignment system becomes as small as 6nm using TTL-alignment. For marks directly affected by CMP-processes technology impact can be controlled within 13nm. We show that, even in a scenario with multiple tools matched to each other, where alignment marks are directly affected by a CMP process step, and where the standard TTL alignment marks are directly affected by a CMP process step, and where the standard TTL alignment system is used, the overall overlay can be controlled within 60nm. Using the ATHENA alignment system, a further improvement is possible.
Electrical Properties of Carbon Nanotube-Reinforced Polymer Composites (2016)

Novel electrically conductive SWCNT-reinforced composites were studied in this work. Incorporating SWCNT into CB/polymer composites provides lowering the percolation threshold. Adding a small quantity of single-walled carbon nanotubes into CB/polymer composites allows reducing CB content in electrically conductive composites and improving rheological and processing properties.
1,4-Bis(diphenylphosphino)butane (2001)

[7688-25-7] C28H28P2 (MW 426.48)





InChI = 1S/C28H28P2/c1-5-15-25(16-6-1)29(26-17-7-2-8-18-26)23-13-14-24-30(27-19-9-3-10-20-27)28-21-11-4-12-22-28/h1-12,15-22H,13-14,23-24H2



InChIKey = BCJVBDBJSMFBRW-UHFFFAOYSA-N



(ligand for metal-catalyzed lactonization of unsaturated alcohols;1 allylic substitution;2 cyclization reactions;3 carbonylations;4 alkyne isomerization;5 alkyne–CO2 coupling6)



Alternate Name: dppb.



Physical Data: mp 135–137 °C.



Form Supplied in: white solid; widely available.



Handling, Storage, and Precautions: readily oxidized in solution to the phosphine oxide and should be handled under N2 or Ar. The compound is air-stable in the solid state.
Molecular mechanism of off-target effects in CRISPR-Cas9 (2018)

Abstract CRISPR-Cas9 is the state-of-the-art technology for editing and manipulating nucleic acids. However, the occurrence of off-target mutations can limit its applicability. Here, all-atom enhanced molecular dynamics (MD) simulations – using Gaussian accelerated MD (GaMD) – are used to decipher the mechanism of off-target binding at the molecular level. GaMD reveals that base pair mismatches in the target DNA at specific distal sites with respect to the Protospacer Adjacent Motif (PAM) induce an extended opening of the RNA:DNA heteroduplex, which leads to newly discovered interactions between the unwound nucleic acids and the protein counterpart. The conserved interactions between the target DNA strand and the L2 loop of the catalytic HNH domain constitute a “lock” effectively decreasing the conformational freedom of the HNH domain and its activation for cleavage. Remarkably, depending on their position at PAM distal sites, DNA mismatches leading to off-target cleavages are unable to “lock” the HNH domain, thereby identifying the ability to “lock” HNH as a key determinant. Consistently, off-target sequences hampering the catalysis have been shown to “trap” somehow the HNH domain in an inactive “conformational checkpoint” state (Dagdas et al. Sci Adv, 2017). As such, this mechanism identifies the molecular basis underlying off-target cleavages and contributes in clarifying a long-lasting open issue of the CRISPR-Cas9 function. It also poses the foundation for designing novel and more specific Cas9 variants, which could be obtained by magnifying the “locking” interactions between HNH and the target DNA in the presence of any incorrect off-target sequence, thus preventing undesired cleavages.
Development and Testing of a Novel Corrosion Inhibitor Technology for Acid Corrosion (2011)

Abstract Corrosion of oilfield tubulars during a stimulation treatment is an acute problem as evidenced by weight loss, pitting, and cracking. Stimulation methodologies such as pickling, acid washing, matrix acidizing and acid fracturing can cause severe acidic corrosion mainly due to the low pH nature of the treatment fluid. The most common approach to mitigate corrosion is to add corrosion inhibitors to the stimulation fluids. To enhance the performance of acid corrosion inhibitors certain chemicals called corrosion inhibitor intensifiers are also commonly used. These intensifiers are sometimes partially soluble thus rendering them ineffective. This paper describes the evaluation of a new more soluble corrosion inhibitor intensifier designed to be effective in stronger acids for longer wellbore contact times. The development and testing of such an inhibitor package is presented with the effects of varying test temperatures, types of stimulation fluids and metallurgies. The paper presents results of acid corrosion testing performed on five different metallurgies namely 13Cr-S110, 718 Inconel, 13Cr-M110, 13Cr95 and 22Cr at 180°F and 220°F. Additionally the stimulation fluid ranged from 15% HCl, 13.5% HCl +1.5% HF and spent acid. The test period was extended to 24 hrs to test the effectiveness of the new intensifier package. The proper adsorption of corrosion inhibitors and intensifiers on the tubular can be altered by the addition of additives. To replicate an actual stimulation scenario the acid systems were tested with commonly used acid additives. The results indicate that the inhibitor package was very effective in providing excellent corrosion protection in extreme test conditions. It was also observed that a large corrosion inhibiting effect was obtained with only a small proportion of synergistic intensifier used. The new, more soluble inhibitor intensifier technology fills the need to enhance corrosion protection in stronger acid environments for a wide variety of metallurgies and longer contact times.
A distributed deadlock resolution algorithm for the AND model (1999)

Previous proposals for Distributed Deadlock Detection/Resolution algorithms for the AND model have the main disadvantage of resolving false deadlocks, that is, nonexisting or currently being resolved deadlocks. This paper provides an algorithm free of false deadlock resolutions, A simple specification for a safe deadlock resolution algorithm is introduced, and the new distributed solution is developed in a hierarchical fashion from its abstract specification. The algorithm is probe-based, uses node priorities, and coordinates the actions of resolvers so that false deadlocks are not resolved. The solution is formally proven correct by using the input-output Automata Model. Finally, a study about the liveness of the algorithm is provided.
Representing and analyzing action plans as networks of concurrent processes (1993)

The problem of constructing a plan representation that can deal with the complexity of representing and analyzing robot behavior in uncertain and dynamic environments is addressed. A concurrent-process based representation is developed which represents both the plan (or controller) and the uncertain and dynamic environment in which the plan operates. A methodology is outlined for analyzing the behavior of this interacting system of plan and world. This methodology is illustrated with a mixed-batch example from the domain of robotic kitting. To balance the theoretical work, a description of the implemented robot kitting cell is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis (2019)

NCT01548404, NCT02210780, NCT01859988, NCT02277743, NCT02277769, NCT02260986, and NCT02755649.
Low-level mechanisms may contribute to paradoxical motion percepts (2009)

A recent series of experiments demonstrated a surprising deterioration of visual motion discrimination with increasing stimulus size for stimuli of high contrast. This counterintuitive finding was explained as a result of surround suppression in visual area V5. Equally paradoxical was the finding that older observers showed better performance than younger observers. This second result was explained as an age-related reduction in surround suppression due to changes in GABA-mediated inhibition. Using an opponent motion stimulus, we find an analogous effect and also find that this effect is much reduced in older observers, to the point where they perform better than younger observers. Our long duration stimulus should be beyond the range at which surround-suppressed neurons in V5 are preferentially activated. Having normalized our stimuli relative to contrast threshold, we show that our results can be entirely explained by the relative contrast of the stimulus and speculate that contrast sensitivity may play a role in previously reported results. Our older observers' data similarly can be explained by the relative contrast of the stimulus. The difference between older and younger observers appears to be a result of a weakening of spatial summation at high contrast in younger observers, perhaps caused by earlier saturation of motion mechanisms.
Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis (2011)

Spatial and timely coordination of cytokinesis is crucial for the maintenance of organelle inheritance and genome integrity. The mitotic exit network (MEN) pathway controls both the timely initiation of mitotic exit and cytokinesis in budding yeast. Here we identified the conserved F-BAR protein Hof1 as a substrate of the MEN kinase complex Dbf2-Mob1 during cytokinesis. We show that polo-like kinase Cdc5 first phosphorylates Hof1 to allow subsequent phosphorylation by Dbf2-Mob1. This releases Hof1 from the septin ring and facilitates Hof1 binding to the medial actomyosin ring (AMR), where Hof1 promotes AMR contraction and membrane ingression. Domain structure analysis established that the central, unstructured, region of Hof1, named the ring localization sequence (RLS), is sufficient to mediate Hof1's binding to the medial ring in a cell cycle-dependent manner. Genetic and functional data support a model in which Dbf2-Mob1 regulates Hof1 by inducing domain rearrangements, leading to the exposure of the Hof1 RLS domain during telophase.
Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA (1999)

All-trans-retinoic acid (RA), an active metabolite of vitamin A, induces the gene expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and suppresses leptin gene expression in white adipose tissue (WAT) when given as an acute dose. These contrasting effects of RA leave in doubt the overall effect of chronic RA or vitamin A supplementation on energy homeostasis. To investigate the effects of dietary vitamin A supplementation on leptin and UCP1 gene expression, rats were fed either a normal diet (2.6 retinol/kg diet) or a vitamin A-supplemented diet (129 mg retinol/kg diet) for 8 weeks, and adiposity, serum leptin levels, leptin mRNA levels in perirenal WAT, UCP1 and UCP2 mRNA levels in BAT, and beta3-adrenergic receptor mRNA levels in BAT and WAT were examined. Rats on both diets gained a similar amount of weight, but there was a small 9% decrease in the adiposity index in the vitamin A-supplemented rats. Dietary vitamin A supplementation increased UCP1 gene expression in BAT by 31%, but suppressed leptin gene expression by 44% and serum leptin levels by 65%. UCP2 and beta3-adrenergic receptor gene expression in BAT and perirenal WAT were unchanged by the vitamin A diet. These data suggest that dietary vitamin A has a role in regulating energy homeostasis by enhancing UCP1 gene expression and decreasing serum leptin levels.
MR‐zero meets RARE MRI: Joint optimization of refocusing flip angles and neural networks to minimize T2‐induced blurring in spin echo sequences (2023)

This work demonstrates that when variable flip angles and a convolutional neural network are optimized jointly in an end-to-end approach, sequences with more efficient minimization of T<sub>2</sub> -induced blurring can be found. This allows faster single- or multi-shot RARE MRI with longer echo trains.