gebhart/patrepeval huggingface dataset:
Implicit Meshes Make for Better Silhouettes (2004)

This paper advocates an implicit-surface representation of generic 3--D surfaces to take advantage of occluding edges in a very robust way. This lets us exploit silhouette constraints in uncontrolled environments that may involve occlusions and changing or cluttered backgrounds, which limit the applicability of most silhouette based methods. This desirable behavior is completely independent from the way the surface deformations are parametrized. To show this, we demonstrate our technique in three very different cases: Modeling the deformations of a piece of paper represented by an ordinary triangulated mesh; tracking a person's shoulders whose deformations are expressed in terms of Dirichlet Free Form Deformations; reconstructing the shape of a human face parametrized in terms of a Principal Component Analysis model.
Structural transformation of terpolymer poly(L-lactide-glycolide-trimethylene carbonate) with shape memory effect during the degradation process (2014)

The purpose of this study was to analyze the changes of the structure of shape memory polymer (SMP) surgical staple made from poly(L-lactide-glycolide-trimethylene carbonate) during in vitro degradation. It is crucial to understand the structure and properties of SMP biomedical polymers during the degradation process as their biodegradation rate should match the therapeutic period. It was confirmed that degradation results in a decrease of Tg and that degradation at a temperature above Tg involves faster dynamics. The hydrolysis of amorphous regions lead to increased crystallinity and erosion of the polymer.
Highly Efficient Full van der Waals 1D p‐Te/2D n‐Bi2O2Se Heterodiodes with Nanoscale Ultra‐Photosensitive Channels (2022)

Abstract Continuous miniaturization of semiconductor devices is the key to boosting modern electronics development. However, this downscaling strategy has been rarely utilized in photoelectronics and photovoltaics. Here, in this work, a full‐van der Waals (vdWs) 1D p‐Te/2D n‐Bi 2 O 2 Se heterodiode with a rationally designed nanoscale ultra‐photosensitive channel is reported. Enabled by the dangling bond‐free mixed‐dimensional vdWs integration, the Te/Bi 2 O 2 Se type‐II diodes show a high rectification ratio of 3.6 × 10 4 . Operating with 100 mV reverse bias or in a self‐power mode, the photodiodes demonstrate excellent photodetection performances, including high responsivities of 130 A W −1 (100 mV bias) and 768.8 mA W −1 (self‐power mode), surpassing most of the reports of other heterostructures. More importantly, a superlinear photoelectric conversion phenomenon is uncovered in these nanoscale full‐vdWs photodiodes, in which a model based on the in‐gap trap‐assisted recombination is proposed for this superlinearity. All these results provide valuable insights in light–matter interactions for further performance enhancement of photoelectronic devices.
Volume Management by Renal Replacement Therapy in Acute Kidney Injury (2008)

Management of fluid balance is one of the basic but vital tasks in the care of critically ill patients. Hypovolemia results in a decrease in cardiac output and tissue perfusion and may lead to progressive multiple organ dysfunction, including the development of acute renal injury (AKI). However, in an effort to reverse pre-renal oliguria, it is not uncommon for patients with established oliguric acute renal failure, particularly when associated with sepsis, to receive excessive fluid resuscitation, leading to fluid overload. In patients with established oliguria, renal replacement therapy may be required to treat hypervolemia. Safe prescription of fluid loss during RRT requires intimate knowledge of the patient's underlying condition, understanding of the process of ultrafiltration and close monitoring of the patient's cardiovascular response to fluid removal. To preserve tissue perfusion in patients with AKI, it is important that RRT be prescribed in a way that optimizes fluid balance by removing fluid without compromising the effective circulating fluid volume. In patients who are clinically fluid overloaded, it is equally important that the amount of fluid removed be as exact as possible. Fluid balance errors can occur as a result of inappropriate prescription, operator error or machine error. Some CRRT machines have potential for significant fluid errors if alarms can be overridden. Threshold values for fluid balance error have been developed which can be used to predict the severity of harm. It is important that RRT education programs emphasize the risk associated with fluid balance errors and with overriding machine alarms.
Maria M. Mota: Bringing Plasmodium Liver Infection to the Centre Stage of Malaria Research (2022)

OPINION article Front. Cell. Infect. Microbiol., 08 February 2022 | https://doi.org/10.3389/fcimb.2022.851484
Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β (2004)

Reactive oxygen species (ROS) are key intermediates in cellular signal transduction pathways whose function may be counterbalanced by antioxidants. Acting as an antioxidant, ascorbic acid (AA) donates two electrons and becomes oxidized to dehydroascorbic acid (DHA). We discovered that DHA directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas AA did not have this effect. When cells were loaded with AA and induced to generate DHA by oxidative stress in cells expressing a constitutive active IKKbeta, NF-kappaB activation was inhibited. Our results identify a dual molecular action of vitamin C in signal transduction and provide a direct linkage between the redox state of vitamin C and NF-kappaB signaling events. AA quenches ROS intermediates involved in the activation of NF-kappaB and is oxidized to DHA, which directly inhibits IKKbeta and IKKalpha enzymatic activity. These findings define a function for vitamin C in signal transduction other than as an antioxidant and mechanistically illuminate how vitamin C down-modulates NF-kappaB signaling.
Proteomic and Bioinformatic Characterization of the Biogenesis and Function of Melanosomes (2006)

Melanin, which is responsible for virtually all visible skin, hair, and eye pigmentation in humans, is synthesized, deposited, and distributed in subcellular organelles termed melanosomes. A comprehensive determination of the protein composition of this organelle has been obstructed by the melanin present. Here, we report a novel method of removing melanin that includes in-solution digestion and immobilized metal affinity chromatography (IMAC). Together with in-gel digestion, this method has allowed us to characterize melanosome proteomes at various developmental stages by tandem mass spectrometry. Comparative profiling and functional characterization of the melanosome proteomes identified approximately 1500 proteins in melanosomes of all stages, with approximately 600 in any given stage. These proteins include 16 homologous to mouse coat color genes and many associated with human pigmentary diseases. Approximately 100 proteins shared by melanosomes from pigmented and nonpigmented melanocytes define the essential melanosome proteome. Proteins validated by confirming their intracellular localization include PEDF (pigment-epithelium derived factor) and SLC24A5 (sodium/potassium/calcium exchanger 5, NCKX5). The sharing of proteins between melanosomes and other lysosome-related organelles suggests a common evolutionary origin. This work represents a model for the study of the biogenesis of lysosome-related organelles.
Serial-link bus: a low-power on-chip bus architecture (2005)

As technology scales, the shrinking wire width increases the interconnect resistivity, while the decreasing interconnect spacing significantly increases the coupling capacitance. This paper proposes reducing the number of bus lines of the conventional parallel-line bus CB architecture by multiplexing each m-bits onto a single line. This bus architecture, the serial-link bus SLB, transforms an n-bit conventional parallel-line bus into an n/m-line (serial-link) bus. The advantage of serial-link buses is that they have fewer lines, and if the bus width is kept the same, serial- link buses will have larger line width and spacing. Increasing the line width has a twofold reduction effect on the line resistance, as the resistivity of sub-100 nm wires significantly drops as the line width increases. Also, increasing the line width and spacing reduces the coupling capacitance between adjacent lines, but increases the line-to-ground capacitance. Thus, an optimum degree of multiplexing m exists that minimizes the bus energy dissipation and maximizes the bus throughput per-unit area. The optimum degree of multiplexing for maximum throughput-per- unit-area and for minimum energy dissipation for the 25-130 nm technologies was determined in this paper. HSPICE simulations show that; for the same throughput-per-unit-area as conventional parallel-line buses, the serial-link bus architecture reduces the energy dissipation by up to 31.42% for a 64-bit bus implemented in an intermediate metal layer of a 50 nm technology and a reduction of 52.7% is projected for the 25 nm technology.
Nanoscale structure and superhydrophobicity of sp2-bonded boron nitride aerogels (2015)

Aerogels have much potential in both research and industrial applications due to their high surface area, low density, and fine pore size distribution. Here we report a thorough structural study of three-dimensional aerogels composed of highly crystalline sp(2)-bonded boron nitride (BN) layers synthesized by a carbothermic reduction process. The structure, crystallinity and bonding of the as-prepared BN aerogels are elucidated by X-ray diffraction, (11)B nuclear magnetic resonance, transmission electron microscopy, and resonant soft X-ray scattering. The macroscopic roughness of the aerogel's surface causes it to be superhydrophobic with a contact angle of ∼155° and exhibit high oil uptake capacity (up to 1500 wt%). The oil can be removed from the BN aerogel by oxidizing in air without damaging the crystalline porous structure of the aerogel or diminishing its oil absorption capacity.
Electrogram‐guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes (2021)

In patients with suspected CS, abnormal EGM-Bx has high sensitivity and low specificity for establishing a definite CS diagnosis. Consideration of substrate abnormalities apparent on preprocedural imaging as an adjunct for selection of biopsy sites may further improve EGM-Bx yield.
Etching of Narrow Porous SiOCH Trenches Using a TiN Metallic Hard Mask (2005)

International audience
Perkin 1 Abstracts: Natural Product Synthesis (2001)

A. Gunn, J. E. Milne, M. de Puit and D. McArthur, J. Chem. Soc., Perkin Trans. 1, 2001, 20-xvi DOI: 10.1039/B108756H
ChemInform Abstract: THERMOLABILE HYDROCARBONS. XXIII. THE DIMER OF 2‐METHYL‐1,1‐DIPHENYLPROPYL RADICALS AND ITS REACTIVITY (1983)

Abstract Thermolabile Hydrocarbons.
Correction: Twisted-graphene-like perylene diimide with dangling functional chromophores as tunable small-molecule acceptors in binary-blend active layers of organic photovoltaics (2021)

Correction for ‘Twisted-graphene-like perylene diimide with dangling functional chromophores as tunable small-molecule acceptors in binary-blend active layers of organic photovoltaics’ by Yu-Che Lin et al. , J. Mater. Chem. A , 2021, DOI: 10.1039/d1ta05697b.
Optimum seismic processing of modeled outcrop data from Van Keulenfjord, Svalbard (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Optimum seismic processing of modeled outcrop data from Van Keulenfjord, SvalbardAuthors: Phan Tien VienEgil TjaalandBoerge ArntsenStaale JohansenPhan Tien VienPetrovietnam PSC Supervising Company, Egil TjaalandNorwegian Univ. of Science and Echnology (NTNU), Boerge ArntsenStatoil Research Centre, Norway, and Staale JohansenStatoil Research Centre, Norwayhttps://doi.org/10.1190/1.1885668 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885668FiguresReferencesRelatedDetailsCited byDecoupling of seismic reflectors and stratigraphic timelines: A modeling study of Tertiary strata from SvalbardStåle Johansen, Espen Granberg, Donatella Mellere, Børge Arntsen, and Torben Olsen23 August 2007 | GEOPHYSICS, Vol. 72, No. 5 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Phan Tien Vien, Egil Tjaaland, Boerge Arntsen, and Staale Johansen, (1997), "Optimum seismic processing of modeled outcrop data from Van Keulenfjord, Svalbard," SEG Technical Program Expanded Abstracts : 1395-1398. https://doi.org/10.1190/1.1885668 Plain-Language Summary PDF DownloadLoading ...
Retrieval Of Individualized Head-Related Transfer Functions For Hearing Aid Applications (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
211 Manufacturing of A1050-A6061 Functionally Graded Porous Aluminum (2010)

Porous aluminum is a multifunctional material with lightweight and high energy absorption properties. In this study, A1050-A6061 functionally graded porous aluminum was fabricated by friction stir processing (FSP) route. It is expected that both mixing a blowing agent into aluminum and bonding A 1050 precursor to A6061 precursor can be conducted by FSP. It was shown that A1050-A6061 seamless functionally graded porous aluminum can be successfully fabricated at a holding temperature of 1003 K and at a holding time of 10 min.
Copolymer Film Alignment: Spontaneous Lamellar Alignment in Thickness‐Modulated Block Copolymer Films (Adv. Funct. Mater. 16/2009) (2009)

Self-alignment of lamellar nanodomains is accomplished by imposing thickness modulation to a block copolymer thin film. Real-time atomic-force microscopy imaging reveals that the self-alignment occurs through the directional growth of well-aligned domains along thickness gradients. This novel self-aligning principle, based on a “geometric anchoring” phenomenon, is reported by S. O. Kim, O. D. Lavrentovich and co-workers on page 2584.
Low-Complexity Adaptive Background Compensation of Coherent Optical Transmitters (2022)

Next generation optical communications will demand coherent transceivers with data rates in the 1.6 Terabit-per-second range and beyond, requiring both high symbol rate and large constellations. In this scenario coherent systems become increasingly sensitive to transmitter imperfections such as In-phase/Quadrature time skew, amplitude and phase errors, bandwidth limitations and mismatches, etc. These impairments must be compensated to achieve satisfactory performance. In this work, we propose a novel and efficient technique for the precompensation of such impairments, requiring minimum additional hardware in current transmitter designs. This scheme is <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">adaptive</i> , as it readjusts itself to cope with time and environment dependent impairments, and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">background</i> , as interruptions of normal operation are not required for the continuous recalibration of the system. Naturally, such <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in-field</i> adaptation demands the real-time system identification of the coherent optical transmitter, which is performed from the sole information provided by a low bandwidth photodiode/analog-to-digital converter chain at the transmitter output. This fact represents a meaningful advance with respect to the usual channel estimation methods, which require the full bandwidth coherent demodulation of the optical output. A theoretical foundation for the proposed scheme is presented. Numerical simulations of a realistic coherent optical transmitter show excellent results for high symbol rate modulation formats.
Abstract 4419: Subtyping of HNSCC single-cell RNA-seq identifies transcriptional programs characterized by suppression of Mtorc1 and Wnt signaling pathways and better patient prognosis (2020)

Abstract Single-cell RNA-seq (scRNA-seq) is an emerging platform for high-throughput profiling of individual cells in a sample and is routinely employed to investigate the transcriptional landscapes of the cellular constituents of tumors. To this end, many scRNA-seq specific clustering algorithms have emerged to analytically partition cells into modules of comparatively similar profiles. To facilitate data driven molecular subtyping of such scRNA-seq clustering results and other large-scale-omics studies, we have developed K2 Taxonomer. K2 Taxonomer is an R package built around a novel top-down hierarchical clustering algorithm, utilizing repeated perturbations of the data to generate robust taxonomical partitions of observations. The software runs additional analyses to define gene co-expression signatures of these modules, as well as to integrate user-input annotations of genes and/or observations. An interactive web portal has been generated to assist in the interrogation of the full compendium of results. We applied K2 Taxonomer to publicly available HNSCC scRNA-seq data, identifying pertinent tumor cell subtypes, distinguished by cell cycle and epithelial-to-mesenchymal transition, and with analytical projection of this signature onto TCGA-HNSCC bulk RNA-seq data exhibiting association with worse survival in TCGA-HNSCC patients. A transcriptional signature corresponding to suppression of Mtorc1 and Wnt/β-catenin signaling was also identified in a sub-population of HNSCCs, and shown to be associated with improved patient survival. Of notice, highly ranked markers of this signature are significantly associated with gene expression changes altered by E7386 - a novel β-catenin/CBP modulator with an activity profile that closely overlaps with that of ICG-001, but exhibits ~50-100-fold lower EC50 values - suggesting a role for this signaling axis in subsets of HNSCC. In conclusion, taxonomical subtyping with K2 Taxonomer provides a novel framework to expand the scope of applicability of scRNA-seq clustering results, and has revealed potentially novel HNSCC subtypes that offer directions for future studies. Citation Format: Eric Reed, Takashi Owa, Kenichi Nomoto, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti. Subtyping of HNSCC single-cell RNA-seq identifies transcriptional programs characterized by suppression of Mtorc1 and Wnt signaling pathways and better patient prognosis [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4419.
SNR-scalable extension of H.264/AVC (2005)

We present an SNR-scalable extension of the H.264/AVC video coding standard. To achieve an efficient SNR-scalable bit-stream representation of a video sequence, the temporal dependencies between pictures are exploited by using an open-loop subband approach. The related temporal analysis-synthesis filter bank structure is generalized to facilitate an adaptive block-based choice between the motion-compensated lifting representations of the Haar filter (uni-directional prediction) and the 5/3 filter (bi-directional prediction), both coupled with multiple-reference frame capabilities. As a remarkable feature of our approach, most components of H.264/AVC are used as specified in the standard, while only a few have been adjusted to the motion-compensated temporal filtering structure. Our proposed SNR-scalable extension was tested for a set of CIF sequences, and the results indicate that a coding efficiency comparable to that of the state-of-the-art H.264/AVC standard can be achieved.
Engineered Blood Vessels (2017)

Abstract The field of tissue engineering has has made significant progress in the past 20 years. Of the many tissues and organs in development, the area of vascular tissue engineering is now one of the most mature. In that regard, we have developed a novel tissue engineered vascular graft (human acellular vessel [HAV]) that addresses many of the limitations of native vein harvest and the performance of both synthetic ePTFE and autologous vein grafts. The HAV is manufactured in a laboratory by culturing human vascular cells within a biodegradable scaffold that forms a mechanically robust tissue engineered blood vessel. The cells are then completely removed (decellularization), leaving behind a non-immunogenic human collagen-based vascular tissue that can be stored on the shelf for months at a time and ready for immediate implantation into any patient. The HAV is currently being evaluated in Phase II and Phase III clinical trials in the U.S., E.U. and Israel as an arteriovenous vascular access graft for hemodialysis in patients with end-stage renal failure and as an arterial substitute for patients in need of vascular bypass for peripheral arterial disease or vascular trauma. Following clinical implantation, we have observed repopulation and remodeling of the manufactured vessel with the hosts' own cells. We hypothesize that the biological composition of the HAV, compared to synthetic vascular grafts, promotes its physiological integration into host tissue including support of normal host cell infiltration and function. Host cells that identify histologically similar to vascular smooth muscle cells appear to repopulate the middle of the vessel and recipient cells characterized as endothelial cells appear to cover the luminal surface of the implanted vessel. Clinical observations of the Phase II trials have demonstrated excellent vessel durability and a freedom from both early and delayed infection. Based on the success of the Phase II studies, a Global Phase III study is underway for patients in need of dialysis access shunts and vascular programs for vascular (arterial) bypass and trauma are expanding. Disclosures Lawson: InnaVasc: Patents &amp; Royalties; Humacyte, Inc.: Employment.
Environmental Sampling with the Boustrophedon Decomposition Algorithm (2022)

The automation of data collection via mobile robots holds promise for increasing the efficacy of environmental investigations, but requires the system to autonomously determine how to sample the environment while avoiding obstacles. Existing methods such as the boustrophedon decomposition algorithm enable complete coverage of the environment to a specified resolution, yet in many cases sampling at the resolution of the distribution would yield long paths with an infeasible number of measurements. Downsampling these paths can result in feasible plans at the expense of distribution estimation accuracy. This work explores this tradeoff between distribution accuracy and path length for the boustrophedon decomposition algorithm. We quantify algorithm performance by computing metrics for accuracy and path length in a Monte-Carlo simulation across a distribution of environments. We highlight conditions where one objective should be prioritized over the other and propose a modification to the algorithm to improve its effectiveness by sampling more uniformly. These results demonstrate how intelligent deployment of the boustrophedon algorithm can effectively guide autonomous environmental sampling.