gebhart/patrepeval huggingface dataset:
Comparative Analysis of Dynamic Proteomic Profiles between in Vivo and in Vitro Produced Mouse Embryos during Postimplantation Period (2013)

Assisted reproductive technology (ART) increasingly is associated with long-term side-effects on postnatal development and behaviors. High-throughput gene expression analysis has been extensively used to explore mechanisms responsible for these disorders. Our study, for the first time, provides a comparative proteomic analysis between embryos after in vivo fertilization and development (IVO, control) and in vitro fertilization and culture (IVP). By comparing the dynamic proteome during the postimplantation period, we identified 300 and 262 differentially expressed proteins (DEPs) between IVO and IVP embryos at embryonic day 7.5 (E7.5) and E10.5, respectively. Bioinformatic analysis showed many DEPs functionally associated with post-transcriptional, translational, and post-translational regulation, and these observations were consistent with correlation analysis between mRNA and protein abundance. In addition to altered gene expression due to IVP procedures, our findings suggest that aberrant processes at these various levels also contributed to proteomic alterations. In addition, numerous DEPs were involved in energy and amino acid metabolism, as well as neural and sensory development. These DEPs are potential candidates for further exploring the mechanism(s) of ART-induced intrauterine growth restriction and neurodevelopmental disorders. Moreover, significant enrichment of DEPs in pathways of neurodegenerative diseases implies the potentially increased susceptibility of ART offspring to these conditions as adults.
A Clinical Device for Measuring Internal-External Rotational Laxity of the Knee (2012)

The novel clinical RMD for measuring rotational laxity of the knee was portable, easy, and comfortable to use in the clinical setting. The RMD showed significant correlation and accuracy compared with sensors of known high accuracy. Side-to-side differences of less than 5° were found in 95% of normal knees, compared with differences of 13° or more for clinical diagnosis of pathological rotational laxity. Measuring knee rotation at the foot showed poor correlation and accuracy.
Strained extremely-thin body In 0.53 Ga 0.47 As-on-insulator MOSFETs on Si substrates (2013)

We report the first demonstration of strained In0.53Ga0.47As-on-insulator (-OI) MOSFETs on Si substrates using the direct wafer bonding (DWB) technique. 1.7 % highly-strained In0.53Ga0.47As-OI structures were successfully fabricated on Si by DWB. Strained In0.53Ga0.47As-OI MOSFETs with Ni-InGaAs metal S/D have successfully operated, for the first time. MOSFETs with 1.7 % tensile strain exhibits 1.65 × effective mobility (μeff) enhancement against InGaAs MOSFET without strain with maintaining high Ion/Ioff ratio of ~105. It is revealed from Hall measurements that the μeff enhancement is attributed to the increase in mobile free electron concentration due to the lowering in the conduction band edge induced by tensile strain.
Untersuchungen im Wittig‐System nach einem ordnenden Konzept auf der Basis alternativer Prinzipien (1990)

Abstract Our results show that the stereoselectivity of the Wittig‐reaction can be controlled by the variation of substituents in accord with the ORDERING CONCEPT OF ALTERNATIV PRINCIPLES [1] (individual pairs, known and unknown classes of alternatives). The “all‐phenyl‐Wittig‐system” having three phenyl groups on phosphorous two in ylid and aldehyd‐position was chosen as a standard for our investigations. Differentiation in ylid‐position and compensations on phosphorous and aldehyd‐position were observed by the comparison of “patterns”. Consequently, most of the selectivity rules of Wittig‐reactions can be explained by the differentiation through alternatives in the ylid‐position. Inversion or conservation of the “patterns” of measured data points to the variation in structure of starting materials, reaction rates and selectivities. Amount controls were also described in certain systems.
Identification of metabolites of dalfampridine (4-aminopyridine) in dog and rat (2013)

Following oral dosing, 4-AP was rapidly absorbed in rats and dogs, with rapid excretion and almost complete urinary recovery in dogs. The primary metabolites in both animal models were 3-hydroxy-4-AP and 3-hydroxy-4-AP sulfate. Systemic clearance not accounted for by renal excretion of 4-AP may occur by liver metabolism by hydroxylation of 4-AP to 3-hydroxy-4-AP followed by sulfate conjugation to 3-hydroxy-4-AP sulfate.
Rasterkraftmikroskopie im Vakuum an plasmabehandeltem und metallisiertem Polycarbonat (1999)

Abstract Der Artikel beschreibt verschiedene kraftmikroskopische Betriebsarten (statische und dynamische Kraftmikroskopie). Anhand unterschiedlicher Proben, vornehmlich Polycarbonat, wird der Einfluß einer ECR‐Plasmabehandlung sowie von Aluminium‐Beschichtungen gezeigt. Die Plasmabehandlung führt zu einer minimalen Morphologieänderung im nm‐Bereich. Schlecht haftendes Aluminium auf unbehandeltem Polycarbonat konnte nur mittels dynamischer Kraftmikroskopie abgebildet werden.
A portable PET image reconstruction system for parallel machines (2002)

With its unique diagnostic capabilities for imaging metabolic body functions, positron emission tomography (PET) has become the superior system among all noninvasive modalities for quantitatively evaluating physiology. Commonly-used reconstruction algorithms such as filtered backprojection (FBP) have been adopted due to their rapid computation but may compromise the resulting image quantitatively with inherent noise amplification. Expectation maximization (EM), an algorithm that includes the stochastic nature of the count data, has been proposed and proved to generate better images, but remains hard to use because of the high complexity of the algorithm. The EM reconstruction algorithm is becoming more feasible with parallel computers which are widely available in research organizations. Different schemes and high-cost hardware platforms have been introduced to speed up the reconstruction process but often incur high costs with their ad-hoc approaches. We introduce a hardware-independent parallel PET image reconstruction system with portable software implementation. To reduce the cost that comes with most parallel platforms, commercial off-the-shelf hardware and software components can be used to build a system with a low cost/performance ratio. The system architecture is also shown to be scalable with increasing image size to meet future needs.
Catalytic Asymmetric Allylic Alkylation with Vinylaluminum Reagents (2008)

A new efficient method for catalytic asymmetric allylic alkylation of allylic phosphates with vinylaluminum reagents is reported. The desired products are obtained in good yields and with enantioselectivities up to 98% ee.
Palladium‐Catalyzed Synthesis of Nonsymmetrically Functionalized Bipyridines, Poly(bipyridines) and Terpyridines (2003)

Abstract Palladium‐catalyzed coupling reactions were employed to prepare nonsymmetric, densely functionalized bipyridines and oligo(bipyridines), featuring sensitive functionalities like alcohol, ester and aldehyde groups. Stille coupling between halo(poly)pyridine and the proper (poly)pyridyltin derivative afforded in good yields nonsymmetric, derivatized oligo(bipyridines), amenable to further synthetic modifications. The methodology was used also to synthesize highly functionalized terpyridines. A series of Suzuki and Stille palladium‐promoted coupling reactions allowed us to obtain in good yields terpyridines bearing two different and differently functionalizable groups, valuable building blocks for the construction of complex supramolecular frameworks. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2003)
A 800MT/s Multiprocessor Bus Interface With Strobe Centering Architecture (2006)

A 65 nm 1.2 V GTL bus interface achieves 800 MT/s 6.4 GB/S data rate in a 3-load multi-processor (MP) environment. To enable a 20% increase in data rate compared to previous design, it utilizes a staged driver, DLL controlled predriver, Tco compensation, data/strobe time shifter, high gain differential amplifier as well as advanced process, voltage and temperature (PVT) compensation design.
On the Mu Repressor and Early DNA Intermediates of Transposition (1984)

Bacteriophage Mu and the related virus D108 are unique in that they replicate DNA by transposition (for review, see Toussaint and Resibois 1983). During lytic growth, about 100 new viral copies are placed randomly in the host chromosome. These viruses also integrate linearly into the chromosome and establish a lysogenic state by producing a repressor. Their ability to change efficiently from the integrated stable state of the lysogen to the rapid replicative cycle makes them powerful systems for biochemical analysis of transposition.
Activated Platelets Provide a Functional Microenvironment for the Antiangiogenic Fragment of Histidine-Rich Glycoprotein (2009)

The angiogenesis inhibitor histidine-rich glycoprotein (HRG) constitutes one of several examples of molecules regulating both angiogenesis and hemostasis. The antiangiogenic properties of HRG are mediated via its proteolytically released histidine- and proline-rich (His/Pro-rich) domain. Using a combination of immunohistochemistry and mass spectrometry, we here provide biochemical evidence for the presence of a proteolytic peptide, corresponding to the antiangiogenic domain of HRG, in vivo in human tissue. This finding supports a role for HRG as an endogenous regulator of angiogenesis. Interestingly, the His/Pro-rich peptide bound to the vessel wall in tissue from cancer patients but not to the vasculature in tissue from healthy persons. Moreover, the His/Pro-rich peptide was found in close association with platelets. Relesate from in vitro-activated platelets promoted binding of the His/Pro-rich domain of HRG to endothelial cells, an effect mediated by Zn(2+). Previous studies have shown that zinc-dependent binding of the His/Pro-rich domain of HRG to heparan sulfate on endothelial cells is required for inhibition of angiogenesis. We describe a novel mechanism to increase the local concentration and activity of an angiogenesis inhibitor, which may reflect a host response to counteract angiogenesis during pathologic conditions. Our finding that tumor angiogenesis is elevated in HRG-deficient mice supports this conclusion.
High density lipoprotein apoprotein variability in a biracial population. (1983)

High density lipoprotein (HDL) cholesterol is a sensitive index for coronary disease in affluent societies. We have measured plasma apoprotein A-I levels (the major HDL protein) in randomly selected groups of urban and rural Fijian Melanesians and Indians. Despite higher prevalence rates of coronary disease and diabetes mellitus in Indians, Indian men and women had significantly higher A-I levels than Melanesian men and women. Multivariate analysis was carried out separately in all men and women of both races and also in younger men and women (less than 45 years old) to determine the predictive values of seven variables that might influence A-I levels. These variables accounted for about 16% of the A-I variation and of this more than one-half was due to ethnic origin. The remainder was largely due to three environmental factors: urbanization, alcohol consumption, and physical activity. Men and women aged 20 to 44 years had significantly higher A-I levels in the town than in villages; alcohol drinkers had significantly higher A-I levels than nondrinkers, and in women physical inactivity resulted in significantly lower A-I levels. Age, smoking cigarettes, and body mass index did not contribute to the differences in A-I levels between the two races, despite less smoking and overweight among Indians. This study of a biracial population, that shares a similar environment but differs in cultural habits, has demonstrated the operation of genetic and environmental factors that explain a minor proportion of apoprotein A-I variability.
Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model (2015)

HDAC6 inhibition significantly improves survival, reduces "cytokine storm," attenuates acute livery injury, increases bacteria clearance and immune cell phagocytosis, and inhibits macrophage apoptosis in a lethal mouse CLP model.
Determination of Location-Specific Solidification Cracking Susceptibility for a Mixed Dissimilar Alloy Processed by Wire-Arc Additive Manufacturing (2022)

Solidification cracking is a major obstacle when joining dissimilar alloys using additive manufacturing. In this work, location-specific solidification cracking susceptibility has been investigated using an integrated computational materials engineering (ICME) approach for a graded alloy formed by mixing P91 steel and Inconel 740H superalloy. An alloy mixture of 26 wt.% P91 and 74 wt.% Inconel 740H, with high configurational and total entropy, was fabricated using wire arc additive manufacturing. Microstructure characterization revealed intergranular solidification cracks in the FCC matrix, which increased in length along with the enrichment of Nb (~27 to 56 wt.%) and Cu (~87 wt.%) in the middle and top regions. DICTRA simulations to model location-specific solidification cracking susceptibility showed that the top region with the highest cooling rate (270 K/s) has the highest solidification cracking susceptibility in comparison with the middle and bottom regions. This is in good agreement with the experimentally observed varying crack length. From Scheil simulations, it was deduced that enrichment of Nb and Cu affected the solidification range as high as ~77%, in comparison with the matrix composition. The overall solidification cracking susceptibility and freezing range was highest for the 26 wt.% P91 alloy amongst the mixed compositions between P91 steel and 740H superalloy, proving that solidification characteristics play a major role in alloy design for additive manufacturing.
Qualitative analysis of a bulk ferromagnetic hysteresis model (2002)

We present a set of equations for a bulk ferromagnetic hysteresis model. We establish the connection between this set of equations and classical energy loss expressions for ferromagnetic hysteresis. We show analytically that for periodic inputs the system of equations has a limit set that is a periodic orbit in the H-M plane, under certain constraints on the parameters.
Room Temperature Detachment Nanolithography Using a Rigiflex Polymeric Mold (2008)

We report on detachment nanolithography of an organic thin film at room temperature mediated by ultraviolet (UV) exposure. A nanopatterned, UV curable polyurethane acrylate (PUA) mold was placed on a spin-coated organic film made of 4,4'-bis[N-1-napthyl-N-phenyl-amino]biphenyl (NPB) under a low pressure (1-2 bar). A higher work of adhesion at the organic/mold interface induced detachment of the contacting layer on silicon or gold substrate, resulting in well-defined nanopatterns without a residual layer. The detachment was highly improved by a short-term UV exposure, rendering the film surface free from contaminant hydrocarbons with a lower cohesive force, as confirmed by Fourier transform infrared (FTIR) spectroscopy and measurements of contact angle of water.
Evidence for the genetic control of immunoglobulin E reactivity to the allergens of Alternaria alternata (2002)

There is a strong genetic influence on IgE response to the mixture of Alternaria allergens and a lesser effect on IgE response to individual allergens.
Chalcogenide Glass-Fiber-Based Mid-IR Sources and Applications (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The Naval Research Laboratory (NRL) is developing chalcogenide glass fibers for applications in the mid- and long-wave IR wavelength regions from 2 to 12 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m. The chalcogen glasses (i.e., glasses based on the elements S, Se, and Te) are transparent in the IR, possess low phonon energies, are chemically durable, and can be drawn into fiber. Both conventional solid core/clad and microstructured fibers have been developed. Chalcogenide glass compositions have been developed that allow rare earth doping to enable rare-earth-doped fiber lasers in the IR. Also, highly nonlinear compositions have been developed with nonlinearities <formula formulatype="inline"><tex Notation="TeX">${\sim}\hbox{1000} \times$</tex></formula> silica that enables nonlinear wavelength conversion from the near IR to the mid- and long-wave IR. In this paper, we review rare-earth-doped chalcogenide fiber for mid- and long-wave IR lasers, and highly nonlinear chalcogenide fiber and photonic crystal fiber for wavelength conversion in the mid- and long-wave IR. </para>
Continuous measurement of segmental and whole body bio-impedance (2002)

Measurement of whole body bioimpedance provides a non-invasive and practical approach to estimate extracellular volume (ECV) in man. However, recent data indicate that ECV cannot be treated as a homogeneous compartment without obtaining paradoxical results. Therefore, bioimpedance measurements should include measurements of body segments such as the arm, the trunk, and the leg. A digital switch was developed and used to consecutively select different body segments for the continuous measurement of whole body and segmental bioimpedance at a minimum sampling period of 3 seconds. Bioimpedance data were modeled to determine the resistance of the ECV in the segments and in the whole body for a period of 30 minutes where subjects were in supine body position followed by a 30 minute standing phase. During supine body position modeled extracellular resistance increased in the leg, the arm, and in the whole body but slightly increased in the trunk. Changes in extracellular resistance reversed with subjects assuming a standing position. These measurements reflect the shifts in ECV between segments to be expected with changes in body position. Simultaneous measurement of bioimpedance in different body segments utilizing this approach might be useful to analyze the nature of fluid shifts in clinical applications such as hemodialysis and ultrafiltration.
Supplementary Legends of Tables 1-2, Figures 1-5 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies (2023)

Supplementary Legends of Tables 1-2, Figures 1-5 from Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
The prevalence and risk factors of post‐inflammatory hyperpigmentation after fractional resurfacing in Asians (2007)

Both the density and energy of the treatment determines the risk of PIH in dark-skinned patients. Density may be of more important but further studies are necessary to determine this. Cooling to prevent bulk tissue heating is also important, especially in small anatomical areas. By using adequate parameters, the risk of PIH in dark-skinned patients can be significantly reduced.
Structure and Internal Stress of Tin-Doped Indium Oxide and Indium–Zinc Oxide Films Deposited by DC Magnetron Sputtering (2007)

Representative transparent conductive oxide films, such as tin-doped indium oxide (ITO) and indium–zinc oxide (IZO) films, were deposited by dc magnetron sputtering using corresponding oxide targets under various total gas pressures (Ptot) ranging from 0.3 to 3.0 Pa. The ITO films deposited at a Ptot lower than 0.7 Pa were polycrystalline and were found to have a large compressive stress of about 1.5 ×109 Pa, whereas the ITO films deposited at 1.5–3.0 Pa were amorphous and had a low tensile stress. In contrast, all the IZO films deposited at a Ptot range of 0.3–3.0 Pa showed an entirely amorphous structure, where the compressive stress in the IZO films deposited at a Ptot lower than 1.5 Pa was lower than that in the ITO films. Such compressive stress was considered to be generated by the atomic peening effect of high-energy neutrals (Ar0) recoiled from the target or high-energy negative ions (O-) accelerated in the cathode sheath toward the film surface.
Designing bifunctional acid–base mesoporous hybrid catalysts for cascade reactions (2013)

Bifunctional mesoporous hybrid materials, containing both proton sponges and acid groups, have been prepared following different synthetic routes: co-condensation processes (sol–gel or micellar one-pot routes) or post-synthetic grafting of the organic functionalities. 1,8-Bis(dimethylamino)naphthalene (DMAN), a proton sponge with high pKa, was used as an organic functional builder base and 3-mercaptopropyltriethoxysilane (MPTES) as a pendant precursor of sulfonic acids. The bifunctional hybrid materials were extensively characterized and were investigated as heterogeneous catalysts for various one-pot C–C bond-forming cascade reactions such as deacetalization–Knoevenagel condensation or deacetalization–nitroaldol (Henry) reaction.
[Experimental minute gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs]. (1984)

150 micrograms/day of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered to a total of 8 dogs, (4 mongrels at age of 4 months and 4 beagles at age of 6 months) over a period of 8 months by Kurihara 's method. As a result of the administration, we found development of minute cancer as follows: In 3 animals, male beagle killed at 575th day, male mongrel at 1, 105th days and male mongrel at 1, 245th days, a total of 20 neoplasms of the stomach was found (18 early cancers and 2 advanced cancers). 13 of which being the minute cancer measuring less than 0.5 cm. There were 11 mucosal cancers and 2 submucosal cancers. When classified by the macroscopic pathological type, none was classified as the elevated type (I, IIa types), 5 lesions as the flat type (IIb type), and 8 lesions as the depression type (IIc type). Two lesions of submucosal cancer belonged to IIc type. When classified by the histological type, 2 were classified as papillary adenocarcinoma, 2 as well differentiated tubular adenocarcinoma, 1 as moderately differentiated tubular adenocarcinoma, 5 as poorly differentiated adenocarcinoma and 3 as signet-ring cell carcinoma.
Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254) (2013)

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Both allosteric agonism and high glutamate fold-shift have been implicated in the neurotoxic profile of some mGlu5 PAMs; however, these hypotheses remain to be adequately addressed. To develop tool compounds to probe these hypotheses, the structure-activity relationship of allosteric agonism was examined within an acetylenic series of mGlu5 PAMs exhibiting allosteric agonism in addition to positive allosteric modulation (ago-PAMs). PAM 38t, a low glutamate fold-shift allosteric ligand (maximum fold-shift ~ 3.0), was selected as a potent PAM with no agonism in the in vitro system used for compound characterization and in two native electrophysiological systems using rat hippocampal slices. PAM 38t (ML254) will be useful to probe the relative contribution of cooperativity and allosteric agonism to the adverse effect liability and neurotoxicity associated with this class of mGlu5 PAMs.