gebhart/patrepeval huggingface dataset:
Single layer reactively steered passive array radiator (2009)

A passive array radiator has been proposed in a single layer configuration to form an adaptive integrated antenna that consists of the inset feed rectangular microstrip patches and the reactance varying control RF circuit. The reactance varying RF circuit part is designed in a folded line configuration such that it does not contribute to the spurious radiation of the antenna. The antenna has been designed at 5.06 GHz for a reasonable beam steering performance.
Modulation of spontaneous B-cell differentiation in macroglobulinemia by retinoic acid (1994)

We previously showed that clonal blood B cells from patients with macroglobulinemia spontaneously differentiate in vitro to plasma cells. This process is dependent on an interleukin (IL)-6 autocrine pathway. We investigate here whether all-trans-retinoic acid (RA) interferes with B-cell differentiation either in patients with IgM gammapathy of undetermined significance (MGUS) or Waldenstrom's macroglobulinemia (WM). RA at a concentration of 10(-5) to 10(-8) mol/L inhibited by 50% to 80% the in vitro differentiation of purified B cells from four of five patients with MGUS and from one of five patients with WM as assessed by the IgM content of day 7 culture supernatants. We next determined whether this effect could be related to an inhibition of IL- 6 secretion by cultured B cells and/or a downregulation of the IL-6 receptor (IL-6R), which was constitutively expressed on patients' blood B cells. A 50% to 100% (mean, 80%) inhibition of IL-6 production was found in seven of 10 patients (five with MGUS and two with WM). The IL- 6R was no more detectable on cells from patients with MGUS after 2 days of treatment with RA and slightly downregulated in patients with WM. It was of interest that B cells susceptible to the action of RA belonged mostly to patients with IgM MGUS, which reinforces our previous data showing distinct requirements for IL-6-dependent differentiation of blood B cells from patients with VM or IgM MGUS.
ESPECTROSCOPÍA Y REACTIVIDAD DE METALES DE TRANSICIÓN. MÓDULOS INTERACTIVOS DE APRENDIZAJE PARA PC (E-LEARNING) Y DISPOSITIVOS MÓVILES (M-LEARNING) (2017)

Se han desarrollado herramientas de aprendizaje autónomo en el campo de la Química, teniendo como temática la espectroscopia y complejos de los metales de transición. Los módulos de aprendizaje que se han desarrollado son de carácter auto-explicativo e interactivo para potenciar el aprendizaje autónomo del alumno, aunque tutelados por el profesor. También son de interés por su potencial aplicación en las modalidades de enseñanza virtual y semipresencial. Los módulos se han desarrollado para ser ejecutados tanto para ordenadores (e-Learning) como para dispositivos móviles (m-Learning), permitiendo trabajar no solo "on-line" sino también "off-line". Es decir, que las aplicaciones puedan ser descargadas e instaladas en los dispositivos fijos y/o móviles para su uso sin conexión a internet.
Isophthalic Acid–Derived Dicarbothioamides as Novel Metal-Free Catalysts in Hydrogen Bond–Promoted Reactions (2009)

Abstract The synthesis of N,N′-diaryl-1,3-benzene-dicarbothioamides was accomplished in only two steps with good yields, and their ability to act as hydrogen-bond donors in Diels–Alder reactions was evaluated. These new organocatalysts were indeed able to promote the cycloaddition of cyclopentadiene to α,β-unsaturated aldehydes. In the attempt to control the absolute stereochemistry of the reaction, chiral catalysts were also prepared by simple condensation of isophthalic acid and α-amino acid derivatives. Molecular mechanics calculations were performed to elucidate the mode of action of these metal-free catalytic systems and to find a rationale for the achieved enantioselectivity.
Flexible Visuo-haptic Display (2013)

This paper describes a flexible visuo-haptic display module. We have developed a flexible electro-active polymer (EAP) actuator and a thin flexible visual display with <TEX>$3{\times}3$</TEX> array configuration via polymer technology. The flexible actuator consists of nine EAP cells vertically moving in response to change in their thickness. The flexible display uses polymer based optical waveguide allowing light to scatter only at specific area. The display film is transparent and identically designed to the array pattern to fit for the arrangement of actuator cells. A pressure sensor is installed under the integrated module. The performance of the actuator is proved to be sufficient for satisfying perceivable range of human touch sense. The integrated system can provide interactive haptic feedback such as key pressing, contact vibration sensations, and etc. in accordance with user input.
Reply to S. Heiland et al (2010)

We thank Heiland et al 1 for their interest in our study. We would like to begin by stating that nowhere in our article 2 does it say that the analysis of magnetic resonance (MR) perfusion imaging is "easy!" Notwithstanding, Heiland et al have raised two important issues regarding our statistics and methods that warrant clarification.
ChemInform Abstract: A NOVEL DISPROPORTIONATION REACTION OF AROMATIC ALDEHYDES INVOLVING CARBON‐CARBON BOND FORMATION (1982)

Abstract Aromatische Aldehyde (IV) reagieren mit Tributylphosphin (I) und Methylthiocyanat (II) letztlich zu den Thioloestern (VI) und den Nitrilen (VII) unter Eliminierung von Tributylphosphinoxid (VIII).
Fine-Scale Genetic Structure in Finland (2017)

Coupling dense genotype data with new computational methods offers unprecedented opportunities for individual-level ancestry estimation once geographically precisely defined reference data sets become available. We study such a reference data set for Finland containing 2376 such individuals from the FINRISK Study survey of 1997 both of whose parents were born close to each other. This sampling strategy focuses on the population structure present in Finland before the 1950s. By using the recent haplotype-based methods ChromoPainter (CP) and FineSTRUCTURE (FS) we reveal a highly geographically clustered genetic structure in Finland and report its connections to the settlement history as well as to the current dialectal regions of the Finnish language. The main genetic division within Finland shows striking concordance with the 1323 borderline of the treaty of Nöteborg. In general, we detect genetic substructure throughout the country, which reflects stronger regional genetic differences in Finland compared to, for example, the UK, which in a similar analysis was dominated by a single unstructured population. We expect that similar population genetic reference data sets will become available for many more populations in the near future with important applications, for example, in forensic genetics and in genetic association studies. With this in mind, we report those extensions of the CP + FS approach that we found most useful in our analyses of the Finnish data.
Sophisticated Vector Beams Produced by Photonic-Crystal Lasers (2010)

Various sophisticated vector beams, which are important for high-resolution microscopy, laser processing, and optical trapping, are successfully produced by the band-edge effect of two-dimensional photonic crystal.
Configurable spare processors: a new approach to system level fault-tolerance (2002)

In this paper, we have developed a methodology for behavioral synthesis of an important class of reconfigurable data path designs called configurable spare processors. Traditionally, a processor failure has been tolerated by dedicating a spare for the processor. However, this has a significant area overhead. In contrast, we present a new technique wherein several processors share one or more configurable spare processors. A configurable spare efficiently implements any of k applications and can be configured to substitute for a faulty processor implementing one of these k applications. In this paper, we address three important techniques targeting configurable spare processor synthesis. Firstly, we address application bundling wherein n application control-data flow graphs (CDFGs) are bundled into at most m groups such that the sum of the areas of the corresponding implementations is minimized. All throughput and fault-tolerance constraints for all applications are satisfied. The area overhead of each of the application bundles is further optimised by retiming the applications within a bundle by considering its effects on the remaining applications in the bundle. Finally, each application bundle is synthesized into a configurable spare processor. The effectiveness of all approaches, algorithms, and software implementations is demonstrated on a number of real-life examples. The validation of all presented examples is complete in a sense that we conducted functional simulation to complete layout implementations.
Supplementary Data from ABT-888 Confers Broad <i>In vivo</i> Activity in Combination with Temozolomide in Diverse Tumors (2023)

Supplementary Data from ABT-888 Confers Broad &lt;i&gt;In vivo&lt;/i&gt; Activity in Combination with Temozolomide in Diverse Tumors
Lowered albumin extravasation rate in heart but not in other organs in β3‐integrin‐deficient mice (2009)

These results show a function for the alphavbeta3 integrin in the regulation of protein permeability, selective for the heart capillaries.
Development of pitch representations in infancy (2009)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
<title>Fabrication of photonic crystals in multilayer organic films</title> (2002)

We present a novel method for making 2D photonic crystal structures. The method relies on exposing a multilayer electron beam resist. The different layers exhibit different dissolution rates in the developer, which makes it possible to produce a perforated membrane released from the substrate if the resist closest to the substrate has a higher dissolution rate than the resist on the surface. The entire structure is created in a single development step. Various structures fabricated with this method are reported.
Immobilized metal affinity chromatography with fused silica microcolumns (1992)

Abstract Fused silica capillaries of 250 μm i.d. were slurry‐packed with a TSK Chelate‐5PW stationary phase. Cu(II) was immobilized on the iminodiacetate surface, and proteins were separated using either an increasing imidazole gradient or a decreasing pH gradient. The microcolumn system increases detection sensitivity without affecting chromatographic behavior. The possible use of this system in the study of tertiary structure relationships between related proteins is explored.
Gait Acceleration during Walking on Snowy Road (2003)

A fall in walking on snowy road often causes sever hip fracture. For especially elderly person, thus hip fracture has high risk for bedridden. The purpose of this study is to investigate the gait characteristics on snowy road. In this experiment, eight healthy subjects walked onto snowy and asphalt roads. Gait accelerations were recorded at 20Hz by micro-accelerators equipped with the head, hip, knee and ankle of them. As a result, it was confirmed that the gate acceleration of each body segment showed different patterns with road conditions. Slipping during gait on snowy road could be detected from the change of acceleration of ankle.
Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes (2004)

We have obtained the single-crystal X-ray crystallographic structures of the bisphosphonates [(1-isoquinolinylamino)methylene]-1,1-bisphosphonate and [[(5-chloro-2-pyridinyl)amino]methylene]-1,1-bisphosphonate, bound to the enzyme 1-deoxyxylulose-5-phosphate reductoisomerase (DXR, EC 1.1.1.267, also known as 2-C-methyl-d-erythritol-4-phosphate synthase), an important target for the development of antimalarial drugs. Our results indicate that both bisphosphonates bind into the fosmidomycin binding site. The aromatic groups are in a shallow hydrophobic pocket, and the phosphonate groups are involved in electrostatic interactions with Mg2+ or a cluster of carboxylic acid groups and lysine while the fosmidomycin phosphonate-binding site is occupied by a sulfate ion (as also observed in the DXR/NADP+ structure). The availability of these two new crystal structures opens up the possibility of the further development of bisphosphonates and related systems as DXR inhibitors and, potentially, as antiinfective agents.
Effects of changing Al mole fraction on the performance of an InGaAlAs-InP DBRTD (2002)

The effects of changing the InAlGaAs alloy composition in the contact, barrier and well layers of a double barrier resonant tunnelling diode (DBRTD), lattice-matched to the InP substrate, on the transmission curves and the peak-to-valley current ratio (PVCD) have been studied. A simple RTD model, in which the applied bias is assumed to drop across the double barrier region, is used in the simulation. The Airy function formalism is used to solve the Schrodinger equation in the structure and the transfer matrix method is used to calculate the transmission coefficient, which is then used to calculate the Tsu and Esaki tunnelling current. It is found that among all the structures studied, RTDs with In/sub 0.52/Al/sub 0.48/As barriers and In/sub 0.52/Al/sub 0.48/As well and contact have the best performance.
Thiophene-Anthranilamides as Highly Potent and Orally Available Factor Xa Inhibitors (2007)

There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the coagulation cascade, is among the more promising targets for anticoagulant therapy and has been the subject of intensive drug discovery efforts. Investigation of a hit from high-throughput screening identified a series of thiophene-substituted anthranilamides as potent nonamidine fXa inhibitors. Lead optimization by incorporation of hydrophilic groups led to the discovery of compounds with picomolar inhibitory potency and micromolar in vitro anticoagulant activity. Based on their high potency, selectivity, oral pharmacokinetics, and efficacy in a rat venous stasis model of thrombosis, compounds ZK 814048 (10b), ZK 810388 (13a), and ZK 813039 (17m) were advanced into development.
Building the Mobile Internet (2011)

The complete guide to technologies and protocols for delivering seamless mobile Internet experiences In Building the MobileInternet, three leading mobility architects and implementers from Cisco present complete foundational knowledge about tomorrows mobile Internet. The authors cover everything from market trends and user expectations to the latest technical approaches for making the Internet mobile by design. Writing for senior technology decision-makers and network design professionals, the authors explain the relatively static nature of the Internets original protocols and design, discuss the concept of mobility, and identify evolving mobility requirements. Next, they thoroughly explain each of todays most promising techniques for building mobility into the Internet, from data link layer to application layer. For each layer, the authors cover mechanisms, protocols, relevant Wi-Fi and cellular architectures, and key use cases. Using this books guidance, mobile network executives can define more effective strategies, network designers can construct more effective architectures, and network engineers can execute more successful migrations. Mark Grayson, Cisco Distinguished Consulting Engineer, leads Ciscos mobile architecture strategy. He has 20+ years of wireless experience ranging from military and satellite systems to the evolution of traditional cellular architectures and the creation of new small cell solutions. He has been granted 50+ patents. Kevin Shatzkamer, Cisco Distinguished Systems Architect, is responsible for long-term strategy and architectural evolution of Cisco mobile wireless networks. His experience ranges from 3G and LTE to security, video distribution, and QoS. He now works with both content providers and service providers to enhance the end-to-end digital media value chain for mobility. Klaas Wierenga, Senior Consulting Engineer in Ciscos Office of the CTO, has 15+ years of experience implementing diverse mobility, security, and identity solutions for enterprises, municipalities, hospitals, and universities. He created the worldwide eduroam service for federated network access in academia. Understanding key mobility market trends: device proliferation, accelerating consumption, and radio-specific scalability problems Reviewing the challenges that mobility presents to conventional Internet architectures Understanding nomadicity, including authentication for users moving across networks and operators Identifying opportunities to address mobility at the data link layer Comparing and using network layer solutions to deliver seamless mobility and session continuity Integrating mobility functionality into the transport/session layer Adding mobility functionality to the application layerincluding support for moving media sessions between devices Redesigning Internet architecture to enable long-term improvements to mobility This book is part of the Networking Technology Series from Cisco Press, which offers networking professionals valuable information for constructing efficient networks, understanding new technologies, and building successful careers.
1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus Lepista sordida (2022)

2-Azahypoxanthine (AHX) was first isolated from the culture broth of the fungus <i>Lepista sordida</i> as a fairy ring-inducing compound. It has since been found that a large number of plants and mushrooms produce AHX endogenously and that AHX has beneficial effects on plant growth. The AHX molecule has an unusual, nitrogen-rich 1,2,3-triazine moiety of unknown biosynthetic origin. Here, we establish the biosynthetic pathway for AHX formation in <i>L. sordida</i>. Our results reveal that the key nitrogen sources that are responsible for the 1,2,3-triazine formation are reactive nitrogen species (RNS), which are derived from nitric oxide (NO) produced by NO synthase (NOS). Furthermore, RNS are also involved in the biochemical conversion of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate (AICAR) to AHX-ribotide (AHXR), suggesting that a novel biosynthetic route that produces AHX exists in the fungus. These findings demonstrate a physiological role for NOS in AHX biosynthesis as well as in biosynthesis of other natural products containing a nitrogen-nitrogen bond.
Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up-Regulation (2009)

Based on these findings, we propose an antiapoptotic signaling pathway that is initiated by FGFR4 and regulating the expression of Bcl-xl through the mitogen-activated protein kinase cascade. Our findings are exemplary for a novel strategy toward the elucidation of diverse signaling pathways that define antiapoptotic potential in cancer cells. These observations open new avenues toward the diagnosis of chemoresistant tumors and therapies targeting FGFR4-overexpressing cancers.
[Mild hemophilia A diagnosed at the onset of acute epidural hematoma after lumbar epidural block]. (2011)

The patient was a 36-year-old man who had been aware of a mild bleeding tendency since childhood, but did not show any history of severe bleeding. After lumbar epidural block was performed for pain caused by lumbar disc herniation, the patient developed paraplegia due to an acute epidural hematoma, and rectovesical disorder. He was admitted to our hospital, and wide fenestration and hematoma evacuation were performed. Because of persistent bleeding, reoperation was performed to achieve hemostasis. Although factor VIII antigen was 138%, its activity was decreased to 18% of normal. A diagnosis of cross-reacting material positive mild hemophilia A was made. Postoperative injection of a factor VIII preparation resulted in complete hemostasis. The activated partial thromboplastin time was within normal range. A thrombin generation test showed reduced endogenous thrombin potential, peak thrombin levels, and prolonged time-to-peak levels. The thrombin generation test, which allows comprehensive assessment of the coagulation profile, was useful for diagnosis and treatment of this case.
Reading Revisited: Evaluating the Usability of Digital Display Surfaces for Active Reading Tasks (2007)

A number of studies have shown that paper holds several advantages over computers for reading tasks. However, these studies were carried out several years ago, and since that time computerized reading technology has advanced in many areas. We revisit the issue of reading in the workplace, comparing paper use to state-of-the-art hardware and software. In particular, we studied how knowledge workers perform reading tasks in four conditions: (1) using paper, (2) using a dual-monitor desktop system, (3) using a pen- enabled horizontal display surface, and (4) using multiple tablet computers. We discuss our findings, noting the strengths and shortcomings of each configuration. Based on these findings, we propose design guidelines for hybrid horizontal + vertical systems that support active reading tasks.
Demonstration of a tunable broadband coupler (2015)

We analyzed and fabricated a novel coupler which possesses wavelength flattened response and splitting ratio tuning capability. The fabricated coupler showed a flattened response to wavelength over 50 nm bandwidth and the coupling power to the cross port can be tuned from 10% to 70%.
The Omnipresence of DYRK1A in Human Diseases (2022)

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.
Electrophotographic process embedded in direct binary search (2002)

A novel halftoning approach that has embedded in it a model for the electrophotographic process is presented. Models for the laser beam, exposure of the organic photoconductor, and the resulting absorptance on the paper are embedded into the direct binary search (DBS) halftoning algorithm. The algorithm is applicable to any arbitrary pixel modulation scheme and is also highly portable between different electrophotographic print engines. Computational issues are addressed to make the approach viable. Results show good exploitation of pixel modulation and improvement over DBS with no printer model throughout most of the tone scale.