gebhart/patrepeval huggingface dataset:
Use of Multiple Parallel Interface Strategies To Create a Seamless Accessible Interface for Next-Generation Information Systems. (1994)

Information systems in public places such as community centers and libraries require some means to provide access to individuals with physical, visual, and, if sound is ins'olved, hearing impairments. This paper proposes a seamless adaptable human interface protocol that would allow users to incrementally modify the command and presentation aspects of the human interface to match their abilities and preferences. The protocol supports multiple control strategies (mouse, keyboard, touchscreen) and presentation forms (standard graphic, large print, voice) simultaneously. In order for the command and control structures to support flexibility and a free flow, a multilevel object-based hierarchy was used. The first implementation of the protocol is in a bibliogiaphic database software package titled Publications, Media and Materials (FMM), which was developed for the Trace Cooperative Electronic Library. Strategies to increase efficiency of access are discussed. Screen displays in various output modes are presented, along with a tabie listing protocol features for individuals with specific types of
&#x201C;Biomimetic micro-electronic systems as neural prostheses: Restoration of lost memory function and enhancement of normal memory function with implantable spatio-temporal models of hippocampal input-output activity&#x201D; (2008)

Dr. Berger leads a multi-disciplinary collaboration with Dr. Sam Deadwyler (Wake Forest Univ.), Dr. John Granacki (USC), Dr. Vasilis Marmarelis (USC), and Dr. Greg Gerhardt (Univ. of Kentucky), that is developing a microchip-based neural prosthesis for the hippocampus, a region of the brain responsible for long-term memory. Damage to the hippocampus is frequently associated with epilepsy, stroke, and dementia (Alzheimer's disease), and is considered to underlie the memory deficits characteristic of these neurological conditions. The essential goals of Dr. Berger's multi-laboratory effort include: (1) experimental study of neuron and neural network function — how does the hippocampus encode information?, (2) formulation of biologically realistic models of neural system dynamics -- can that encoding process be described mathematically to realize a predictive model of how the hippocampus responds to any event?, (3) microchip implementation of neural system models -- can the mathematical model be realized as a set of electronic circuits to achieve parallel processing, rapid computational speed, and miniaturization?, and (4) creation of hybrid neuron-silicon interfaces -- can structural and functional connections between electronic devices and neural tissue be achieved for long-term, bi-directional communication with the brain? By integrating solutions to these component problems, the team is realizing a microchip-based model of hippocampal nonlinear dynamics that can perform the same function as part of the hippocampus. Through bi-directional communication with other neural tissue that normally provides the inputs and outputs to/from a damaged hippocampal area, the biomimetic model could serve as a neural prosthesis. A proof-of-concept will be presented using rats that have been chronically implanted with stimulation/recording micro-electrodes throughout the dorsoventral extent of the hippocampus, and that have been trained using a delayed, non-match-to-sample task. Normal hippocampal functioning is required for successful delayed non-match-to-sample memory. Memory/behavioral function of the hippocampus is blocked pharmacologically, and then in the presence of the blockade, hippocampal memory/behavioral function is restored by a multi-input, multi-output model of hippocampal nonlinear dynamics that interacts bi-directionally with the hippocampus. The model is used to predict output of the hippocampus in the form of spatio-temporal patterns of neural activity in the CA1 region; electrical stimulation of CA1 cells is used to “drive” the output of hippocampus to the desired (predicted) state. These results show for the first time that it is possible to create “hybrid electro-biological” systems that display normal physiological properties, and thus, may be used as neural prostheses to restore damaged brain regions.
Cooperative behavior in periodically driven noisy integrate-fire models of neuronal dynamics (1996)

The dynamics of the standard integrate-fire model and a simpler model (that reproduces the important features of the integrate-fire model under certain conditions) of neural dynamics are studied in the presence of a deterministic external driving force, taken to be time-periodic, and white background noise. Both models possess resonant phenomena in the first passage probability distribution and mean first passage time, arising from the interplay of characteristic time scales in the system. \textcopyright{} 1996 The American Physical Society.
A Recombinant Reporter System for Monitoring Reactivation of an Endogenously DNA Hypermethylated Gene (2014)

Reversing abnormal gene silencing in cancer cells due to DNA hypermethylation of promoter CpG islands may offer new cancer prevention or therapeutic approaches. Moreover, such approaches may be broadly applicable to enhance the efficacy of radiotherapy, chemotherapy, or immunotherapy. Here, we demonstrate the powerful utility of a novel gene reporter system to permit studies of the dynamics, mechanisms, and translational relevance of candidate therapies of this type in human colon cancer cells. The reporter system is based on in situ modification of the endogenous locus of the tumor-suppressor gene SFRP1, a pivotal regulator of the Wnt pathway that is silenced by DNA hypermethylation in many colon cancers. The modified SFRP1-GFP reporter allele used remained basally silent, like the unaltered allele, and it was activated only by drug treatments that derepress gene silencing by reversing DNA hypermethylation. We used the established DNA methyltransferase inhibitor (DNMTi) 5-aza-deoxycitidine (DAC) to show how this system can be used to address key questions in the clinical development of epigenetic cancer therapies. First, we defined conditions for which clinically relevant dosing could induce sustained induction of RNA and protein. Second, we found that, in vivo, a more prolonged drug exposure than anticipated was essential to derepress gene silencing in significant cell numbers, and this has implications for generating effective anticancer responses in patients with hematopoietic or solid tumors. Finally, we discovered how histone deacetylase inhibitors (HDACi) alone, when administered to cells actively replicating DNA, can robustly reexpress the silenced gene with no change in promoter methylation status. Taken together, our findings offer a new tool and insights for devising optimal clinical experiments to evaluate DNMTi and HDACi, alone or in combination, and with other cancer treatments, as agents for the epigenetic management and prevention of cancer.
Resonant and Nonresonant 3D Metallic Metamaterials: Membrane Projection Lithography. (2016)

Abstract not provided.
Enabling SWIPT via OFDM-DC (2019)

We propose a novel Simultaneous Wireless Information and Power Transmission (SWIPT) scheme to enable a compatible multiplexing of energy and information based on the frequency that can be used with the state-of-art transceivers. In the proposed scheme, the transmitter superimposes a Direct-Current (DC) signal on Orthogonal Frequency-Division Multiplexing (OFDM) Radio Frequency (RF) signal to generate OFDM-DC signal for SWIPT where the OFDM part is used for information transmission and the DC signal is used for energy transfer. The power level of the DC signal is configured by a controller at the transmitter side. The corresponding receiver is constructed with direct-conversion-receiver front-end such that the DC signal is extracted using a low-pass filter whose bandwidth is configured based on the subcarrier spacing of the OFDM waveform and then fed to a voltage-to-current converter to generate current to charge a battery for energy storage. The OFDM signal without DC power signal is then fed to Analog-to-Digital (A/D) converter for information decoding. The numerical and simulation evaluations provide encouraging evidence in the favor of the proposed OFDM-DC scheme.
Control of microwave-propelled sails using delayed measurements (2002)

This paper is concerned with the control of carbon fiber sail structures that are being studied in a series of experiments at the Jet Propulsion Laboratory (JPL) and at the University of California, Irvine. The passive dynamic stability in the one-dimensional (1-D) case was studied in an earlier paper in terms of the fixed points of the trajectories for the governing equations of motion. The simple 1-D model introduced the possibility of controlling a microwave-propelled sail using various nonlinear control strategies, using both position and velocity measurements. In the current paper, we assume that velocity measurements are unavailable, and that the position measurements are delayed (due to the finite speed of light). We then use a novel feedback that employs delayed position measurements only to stabilize the sail about an equilibrium position. The paper will also contain preliminary results on studying the stability of the full 3-D sail model, and potential control strategies.
Compostability of cellulose acetate films (1994)

Abstract Composting is an accelerated biological decay process viewed by many to be a potential solution to the solid‐waste management crisis existing in many parts of the world. As part of a program to develop environmentally nonpersistent polymers that are compatible with a composting environment, we have developed a bench‐scale compost methodology that emulates a high efficiency municipal windrow composting operation. A series of cellulose acetate films, differing in degree of substitution, were evaluated in this bench‐scale system. In addition, commercially available biodegradable polymers such as poly(hydroxybutyrate‐ co ‐valerate) (PHBV) and polycaprolactone (PCL) were included as points of reference. Based on film disintegration and on film weight loss, cellulose acetates, having degrees of substitution less than approximately 2.20, compost at rates comparable to that of PHBV. NMR and GPC analyses of composted films indicate that low molecular weight fractions are removed preferentially from the more highly substituted and slower degrading cellulose acetates. © 1994 John Wiley &amp; Sons, Inc.
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner (2023)

Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a &lt;i&gt;TP53&lt;/i&gt;-Dependent Manner
Sockpuppet Detection in Wikipedia: A Corpus of Real-World Deceptive Writing for Linking Identities (2013)

This paper describes the corpus of sockpuppet cases we gathered from Wikipedia. A sockpuppet is an online user account created with a fake identity for the purpose of covering abusive behavior and/or subverting the editing regulation process. We used a semi-automated method for crawling and curating a dataset of real sockpuppet investigation cases. To the best of our knowledge, this is the first corpus available on real-world deceptive writing. We describe the process for crawling the data and some preliminary results that can be used as baseline for benchmarking research. The dataset will be released under a Creative Commons license from our project website: http://docsig.cis.uab.edu.
Lipase‐Catalyzed Resolution of 4‐Trimethylsilyl‐3‐Butyn‐2‐ol and Conversion of the ( R )‐Enantiomer to ( R )‐3‐Butyn‐2‐yl Mesylate and ( P )‐1‐Tributylstannyl‐1,2‐Butadiene (2005)

Abstract (R)‐4‐Trimethylsilyl‐3‐butyn‐2‐yl acetate (S)‐4‐Trimethylsilyl‐3‐butyn‐2‐yl succinate 4‐Trimethylsilyl‐3‐butyn‐2‐ol (R)‐4‐Trimethylsilyl‐3‐butyn‐2‐yl mesylate Vinyl acetate Diisobutylaluminum hydride Butyllithium Cuprous bromide‐dimethylsulfide complex ( P )‐1‐Tributylstannyl‐1, 2‐butadiene
Supplemental table S2 from Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring—The TADE Study (2023)

&lt;p&gt;Frequency of CYP2D6 alleles in study subjects compared to published frequencies for selected race/ ethnic groups&lt;/p&gt;
MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays (2020)

To investigate relationships between computer-extracted breast magnetic resonance (MR) imaging phenotypes with multigene assays of MammaPrint, Oncotype DX, and PAM50 to assess the role of radiomics in evaluating the risk of breast cancer recurrence.
Supplementary Table 4B from Tumor Suppressor Functions of <i>ARLTS1</i> in Lung Cancers (2023)

Supplementary Table 4B from Tumor Suppressor Functions of &lt;i&gt;ARLTS1&lt;/i&gt; in Lung Cancers
Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients (2015)

Our study confirms the alteration of the bacterial microbiota and is the first demonstration of the existence of an altered fungal microbiota in Crohn's disease patients, suggesting that fungi may play a role in pathogenesis.
Melanin: Structure, Function, and Biosynthesis inCryptococcus (2014)

There is an extensive body of evidence from several laboratories that establishes a role for melanization in virulence, providing a fascinating example of how a microorganism can utilize a ubiquitous pigment to undermine host defense mechanisms. Melanin-deficient mutant strains generated by UV-irradiation are avirulent in murine models of cryptococcal infection. The majority of Cryptococcus neoformans melanin is produced by Lac1, although a second laccase enzyme, Lac2, adjacent to LAC1 in the genome exists. Various microscopy techniques were used to develop the melanin model, including atomic force and scanning electron microscopy to examine the surface structure of melanin, transmission electron microscopy (TEM) to study cross sections of melanin, and nuclear magnetic resonance (NMR) cryoporometry to investigate the porosity of melanin. In the environment, melanin is thought to protect C. neoformans from various stresses including enzymatic degradation, radiation (UV, solar, gamma), and heavy metals (silver nitrate) while providing thermotolerance and structural integrity to withstand osmotic challenges. Melanin-binding drugs may be useful as therapeutics against C. neoformans infection. In fact, administration of melanin-binding monoclonal antibodies (MAbs) prolongs the survival of mice in a lethal intravenous infection model. In this study, the fungal burdens of collected brains and lungs of infected mice were taken 7 days after infection, and mice administered MAbs to melanin had significantly lower fungal burdens than control mice administered irrelevant immunoglobulin. Early studies that linked melanin to C. neoformans virulence used classical genetic techniques to generate mutants through nonspecific mutagenesis to identify yeast cells deficient in melanin production.
Feasibility Study of 45-nm-Node Scaled-Down Cu Interconnects With Molecular-Pore-Stacking (MPS) SiOCH Films (2007)

A feasibility study was done for 45-nm-node Cu interconnects using a novel molecular-pore-stacking (MPS) SiOCH film (k = 2.45), taking electron scattering in the scaled-down Cu lines into consideration. The as-deposited MPS SiOCH film, formed by plasma polymerization of a robust six-member-ring (hexagonal) siloxane with large steric-hindered hydrocarbon side chains, has self-organized subnanometer pores. An oxidation-damage-free dual-hard-mask etching process, along with a benzocylobuten liner technique, preserved the low permittivity of the MPS film in the Cu lines, with excellent interline dielectric reliability. The line aspect ratio was also balanced to decrease not only the interconnect parasitic capacitance but also the Cu line resistivity, which is increased by the electron scattering in the narrow lines. By combining the above etching process and the line-aspect control, the feasibility of the MPS SiOCH film was confirmed with outstanding performance and excellent reliability for the 45-nm-node ultralarge scale integrations
A simple synthesis of 13C6‐labelled flavone and 5‐methoxyflavone (1994)

Abstract The 13 C 6 ‐labelled molecules, flavone and 5‐methoxyflavone, with the carbon‐13 label at all six carbons of the aromatic B ring, have been prepared for use as internal standards in isotope dilution‐mass spectrometry. The key step involves addition of a labelled benzoyl group to the methyl group of a hydroxyacetophenone, forming a 1,3‐diketone. Overall yields from 13 C 6 ‐benzoic acid were 38% for the labelled flavone and 45% for the labelled 5‐methoxyflavone.
Inertial Force Sensing System for Partner Robots (2006)

An inertial force sensing system for partner robot control has been developed. We named this system MOST (MOtion Sensing Technology). The MOST consists of 3 angular rate sensors, 3 acceleration sensors, and a DSP (digital signal processor). The acceleration sensor is a semiconductor type and the angular rate sensor is a quartz type. The sensors have been made by MEMS (micro electro mechanical systems) technology for mass-produced cars. They are good for miniaturization of the sensing unit. Posture angle is generally obtained by integrating the angular rate over time. However, there was the divergence of the posture angle due to the offset output integration. New algorithm was proposed to suppress the divergence of the posture angle with the DSP in real-time. The performance of the sensing system, MOST, was demonstrated on the TOYOTA partner robots in the EXPO 2005 Aichi, Japan.
Widespread Distribution of Brain Dopamine Receptors Evidenced with [ 125 I]Iodosulpride, a Highly Selective Ligand (1985)

The new benzamide derivative [125I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.
Photochemistry of N‐Phenyl Dibenzothiophene Sulfoximine† (2021)

Sulfoximines are popular scaffolds in drug discovery due to their hydrogen bonding properties and chemical stability. In recent years, the role of reactive intermediates such as nitrenes has been studied in the synthesis and degradation of sulfoximines. In this work, the photochemistry of N-phenyl dibenzothiophene sulfoximine [5-(phenylimino)-5H-5λ<sup>4</sup> -dibenzo[b,d]thiophene S-oxide] was analyzed. The structure resembles a combination of N-phenyl iminodibenzothiophene and dibenzothiophene S-oxide, which generate nitrene and O(<sup>3</sup> P) upon UV-A irradiation, respectively. The photochemistry of N-phenyl dibenzothiophene sulfoximine was explored by monitoring the formation of azobenzene, a photoproduct of triplet nitrene, using direct irradiation and sensitized experiments. The reactivity profile was further studied through direct irradiation experiments in the presence of diethylamine (DEA) as a nucleophile. The studies demonstrated that N-phenyl dibenzothiophene sulfoximine underwent S-N photocleavage to release singlet phenyl nitrene which formed a mixture of azepines in the presence of DEA and generated moderate amounts of azobenzene in the absence of DEA to indicate formation of triplet phenyl nitrene.
Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium. (1994)

Nitric oxide (NO) is an important mediator of physiologic and inflammatory processes in the lung. To better understand the role of NO in the airway, we examined constitutive NO synthase (NOS) gene expression and function in NCI-H441 human bronchiolar epithelial cells, which are believed to be of Clara cell lineage. NOS activity was detected by [3H]arginine to [3H]citrulline conversion (1,070 +/- 260 fmol/mg protein per minute); enzyme activity was inhibited 91% by EGTA, consistent with the expression of a calcium-dependent NOS isoform. Immunoblot analyses with antisera directed against neuronal, inducible, or endothelial NOS revealed expression solely of endothelial NOS protein. Immunocytochemistry for endothelial NOS revealed staining predominantly in the cell periphery, consistent with the association of this isoform with the cellular membrane. To definitively identify the NOS isoform expressed in H441 cells, NOS cDNA was obtained by degenerate PCR. Sequencing of the H441 NOS cDNA revealed 100% identity with human endothelial NOS at the amino acid level. Furthermore, the H441 NOS cDNA hybridized to a single 4.7-kb mRNA species in poly(A)+ RNA isolated from H441 cells, from rat, sheep, and pig lung, and from ovine endothelial cells, coinciding with the predicted size of 4.7 kb for endothelial NOS mRNA. Guanylyl cyclase activity in H441 cells, assessed by measuring cGMP accumulation, rose 6.6- and 5.4-fold with calcium-mediated activation of NOS by thapsigargin and A23187, respectively. These findings indicate that endothelial NOS is expressed in select bronchiolar epithelial cells, where it may have autocrine effects through activation of guanylyl cyclase. Based on these observations and the previous identification of endothelial NOS in a kidney epithelial cell line, it is postulated that endothelial NOS may be expressed in unique subsets of epithelial cells in a variety of organs, serving to modulate ion flux and/or secretory function.
A lipid modified ubiquitin is packaged into particles of several enveloped viruses (1999)

An anti-ubiquitin cross-reactive protein which migrates more slowly (6.5 kDa) by SDS-PAGE than ubiquitin was identified in African swine fever virus particles. This protein was extracted into the detergent phase in Triton X-114 phase separations, showing that it is hydrophobic, and was radiolabelled with both [3H]palmitic acid and [32P]orthophosphate. This indicates that the protein has a similar structure to the membrane associated phosphatidyl ubiquitin described in baculovirus particles. A similar molecule was found in vaccinia virus and herpes simplex virus particles, suggesting that it may be a component of uninfected cell membranes, which is incorporated into membrane layers in virions during morphogenesis.
ChemInform Abstract: The Catalytic Diels‐Alder Reaction Using Combined Catalyst System of Diphenyltin Sulfide or Lawesson′s Reagent and Silver Perchlorate. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhanced Power Conversion Efficiency of Graphene/Silicon Heterojunction Solar Cells Through NiO Induced Doping (2015)

We report a doping strategy, where nickel oxide (NiO) nanoparticle film coating is employed for graphene/Si heterojunction solar cells to improve the power conversion efficiency (PCE). NiO doping has been shown to improve the short circuit current (J(SC)) by 12%, open circuit voltage (V(OC)) by 25% and fill factor (FF) by 145% of the cells, in turn increasing the PCE from 1.37% to 4.91%. Furthermore, NiO doped graphene/Si solar cells don't show any significant performance degradation over 10 days revealing that NiO doping can be a promising approach for practical applications of graphene in solar cells.