gebhart/patrepeval huggingface dataset:
Correspondence (1998)

Chillag, Kim J. M.D.; Francis, Charles W. M.D.; Totterman, Saara M.D.; Boyd, Allen D. Jr., M.D.; Marder, Victor J. M.D.; Liebert, Kristin M. M.A.; Pellegrini, Vincent D. Jr., M.D.; Stulberg, Bernard N. M.D.; Ayers, David C. M.D.; Rosenberg, Aaron M.D.; Kessler, Craig M.D.; Johanson, Norman A. M.D.
Emission Spectrum of a Dressed Exciton-Biexciton Complex in a Semiconductor Quantum Dot (2008)

The photoluminescence spectrum of a single quantum dot was recorded as a secondary resonant laser optically dressed either the vacuum-to-exciton or the exciton-to-biexciton transitions. High-resolution polarization-resolved measurements using a scanning Fabry-Pérot interferometer reveal splittings of the linearly polarized fine-structure states that are nondegenerate in an asymmetric quantum dot. These splittings manifest as either triplets or doublets and depend sensitively on laser intensity and detuning. Our approach realizes complete resonant control of a multiexcitonic system in emission, which can be either pulsed or continuous wave, and offers direct access to the emitted photons.
Stereoselectivity of Induction of the Retinoblastoma Gene Product (pRb) Dephosphorylation by D-erythro-Sphingosine Supports a Role for pRb in Growth Suppression by Sphingosine (1995)

Sphingosine has been shown to inhibit cell growth in many cell lines although the mechanism of this effect remains obscure. More recently, D-erythro-sphingosine has been shown to act as an early inducer of dephosphorylation of the retinoblastoma gene product (pRb) in the lymphoblastic leukemia cell line MOLT-4 [Chao, R., Khan, W., & Hannun, Y.A. (1992) J. Biol. Chem., 267, 23459-23462]. In the current study, the role of the natural D-erythro-sphingosine in regulation of cell growth and pRb dephosphorylation was evaluated using chemically synthesized pure isomers of sphingosine. Of the four possible stereoisomers of sphingosine, D-erythro-sphingosine was most active in inducing dephosphorylation of pRb protein with an EC50% of 0.6 microM whereas its enantiomer L-erythro-sphingosine was 8-fold less potent with an EC50% of 5 microM. The dose responses for inhibition of cell growth were nearly identical to the EC50% for pRb dephosphorylation with D-erythro-sphingosine causing 50% inhibition at 0.6 microM whereas L-erythro-sphingosine was 5-6-fold less potent. All of the stereoisomers were taken up by the cells, and the greater potency of D-erythro-sphingosine was not due to differences in cellular uptake. The metabolism of D-erythro-sphingosine was also studied to evaluate the possible role of sphingosine metabolites on regulation of retinoblastoma protein. Evidence is provided against a role for ceramide or sphingosine 1-phosphate as mediators of the effects of sphingosine on pRb dephosphorylation.(ABSTRACT TRUNCATED AT 250 WORDS)
Sequential Doping Reveals the Importance of Amorphous Chain Rigidity in Charge Transport of Semi-Crystalline Polymers (2017)

Sequential doping is a promising new doping technique for semicrystalline polymers that has been shown to produce doped films with higher conductivity and more uniform morphology than conventional doping processes, and where the dopant placement in the film can be controlled. As a relatively new technique, however, much work is needed to understand the resulting polymer-dopant interactions upon sequential doping. A combination of infrared spectroscopy and theoretical simulations shows that the dopants selectively placed in the amorphous regions in the film via sequential doping result in highly localized polarons. We find that the presence of dopants within the amorphous regions of the film leads to an increase in conjugation length of the amorphous chains upon doping, increasing film connectivity and hence improving the overall conductivity of the film compared with the conventional doping processes.
A QUANTUM-SPONGE MODEL FOR POROUS SILICON (1996)

We propose a “quantum-sponge” model for porous silicon. This model exhibits energy-gap widening and nonexponential decay of photoluminescence describable by the stretched exponential function. These properties are in good agreement with those observed for porous silicon. We suggest that the fractal character of its wave functions is the origin of the nonexponential decay of photoluminescence.
Alterations in T Cell Phenotype and Human Immunodeficiency Virus Type 1–Specific Cytotoxicity after Potent Antiretroviral Therapy (2001)

Cytotoxic T lymphocytes (CTLs) are an important defense against human immunodeficiency virus (HIV) type 1 but ultimately fail to control infection. To determine whether more efficient sustained immunity is induced by suppressing replication, the evolution of T cell phenotypes and HIV-specific CD8+ lymphocytes was prospectively investigated in 41 patients initiating combination therapy. Suppression of viremia to <200 copies/mL was associated with increases in naive cells (CD45RA+62L+) and declines in activated T cells (CD95+ cell counts and CD38+ HLA-DR+). HIV-specific tetramer-staining CD8+ T cells were detected in 6 of 10 HLA-A*0201-positive persons, which declined in 5 with treatment. CTL precursor frequencies were markedly consistent before and after treatment. Eight (72%) of 11 recognized > or =1 immunodominant epitope, representing either a new or an increased CTL response after treatment. Thus, activated CD8+ T cells, including those recognizing immunodominant epitopes, decline with combination therapy. However, the overall level of antigen-specific cells that are capable of differentiating into effectors remains stable, and the recognition of new epitopes may occur.
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study (2021)

Wellcome Trust.
Adrenergic supersensitivity in Parkinsonians with orthostatic hypotension (1990)

The adrenergic status was studied through evaluation of platelet alpha 2-adrenoceptor number [( 3H]yohimbine binding sites), plasma catecholamine levels and blood pressure response to noradrenaline infusion in three groups of subjects (1) Parkinsonians with orthostatic hypotension; (2) Parkinsonians without orthostatic hypotension; and (3) control subjects. In Parkinsonians with orthostatic hypotension, systolic and diastolic blood pressures significantly (P less than 0.05) decreased from 144 +/- 9 and 76 +/- 6 mmHg in the lying position to 95 +/- 12 and 60 +/- 7 mmHg after 5 min standing. In these patients, noradrenaline plasma levels were significantly low (62 +/- 11 pg ml-1, (P less than 0.05) when compared with controls (219 +/- 13 pg ml-1) whereas no difference was noticed in Parkinsonians without orthostatic hypotension (195 +/- 14 pg ml-1). The noradrenaline dose required for a 25 mmHg increase in systolic blood pressure was significantly (P less than 0.01) lower in Parkinsonians with orthostatic hypotension (0.19 +/- 0.03 microgram kg-1) when compared with Parkinsonians without orthostatic hypotension (0.86 +/- 0.11 microgram kg-1) or with controls (0.68 +/- 0.1 microgram kg-1). Platelet alpha 2-adrenoceptor number was higher in Parkinsonians with orthostatic hypotension (313 +/- 52 fmol mg-1 protein) than in Parkinsonians without orthostatic hypotension (168 +/- 9 fmol mg-1 protein) or in controls (175 +/- 4 fmol mg-1 protein) with no change in Kd. This study demonstrates that in patients with Parkinson's disease, orthostatic hypotension is associated with an increase in both vascular sensitivity to noradrenaline and platelet alpha 2-adrenoceptor number.(ABSTRACT TRUNCATED AT 250 WORDS)
Solid electrolyte memory for flexible electronics (2007)

Programmable metallization cell (PMC) memory is a non-volatile memory that stores data states as programming current-dependent resistance levels via growth or dissolution of a metallic electrodeposit between the two electrodes. PMC memory is extremely scalable and has shown good performance in terms of switching speed, retention and endurance. Another interesting property of this technology is that the devices are inherently flexible. In this paper, we demonstrate that this memory shows great potential for integration with flexible thin-film technology. We show that a PMC memory element can be controlled with a TFT switching element and that PMC devices can be fabricated on a flexible substrate and can continue to operate after being subjected to a high degree of bending.
The Highly Robust Electrical Interconnects and Ultrasensitive Biosensors Based on Embedded Carbon Nanotube Arrays (2003)

We report on our recent breakthroughs in two different applications using well-aligned carbon nanotube (CNT) arrays on Si chips, including (1) a novel processing solution for highly robust electrical interconnects in integrated circuit manufacturing, and (2) the development of ultrasensitive electrochemical DNA sensors. Both of them rely on the invention of a bottom-up fabrication scheme which includes six steps, including: (a) lithographic patterning, (b) depositing bottom conducting contacts, (c) depositing metal catalysts, (d) CNT growth by plasma enhanced chemical vapor deposition (PECVD), (e) dielectric gap-filling, and (f) chemical mechanical polishing (CMP). Such processes produce a stable planarized surface with only the open end of CNTs exposed, whch can be further processed or modified for different applications. By depositing patterned top contacts, the CNT can serve as vertical interconnects between the two conducting layers. This method is fundamentally different fiom current damascene processes and avoids problems associated with etching and filling of high aspect ratio holes at nanoscales. In addition, multiwalled CNTs (MWCNTs) are highly robust and can carry a current density of 10(exp 9) A/square centimeters without degradation. It has great potential to help extending the current Si technology. The embedded MWCNT array without the top contact layer can be also used as a nanoelectrode array in electrochemical biosensors. The cell time-constant and sensitivity can be dramatically improved. By functionalizing the tube ends with specific oligonucleotide probes, specific DNA targets can be detected with electrochemical methods down to subattomoles.
Correction to “Temperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether Inhibitors” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "Temperature-Dependent Spin Crossover in Neuronal Nitric Oxide Synthase Bound with the Heme-Coordinating Thioether Inhibitors"Tzanko Doukov, Huiying Li, Ajay Sharma, Jeffrey D. Martell, S. Michael Soltis, Richard B. Silverman, and Thomas L. Poulos*Cite this: J. Am. Chem. Soc. 2013, 135, 18, 7080Publication Date (Web):April 26, 2013Publication History Published online26 April 2013Published inissue 8 May 2013https://pubs.acs.org/doi/10.1021/ja3105472https://doi.org/10.1021/ja3105472correctionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views935Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (120 KB) Get e-Alertsclose Get e-Alerts
Analysis of a Molecular Beam Produced by the Spray-Jet Technique with Femtosecond Laser Mass Spectroscopy (2007)

We previously developed a molecular beam apparatus with the spray-jet technique to produce a molecular beam of non-volatile molecules under high vacuum from sprayed mists of sample solutions. The apparatus is used in spectroscopic studies or is a means of molecular beam deposition. We analyzed the molecular beam with femtosecond laser mass spectroscopy and conventional nanosecond laser mass spectroscopy. The information obtained from both mass spectroscopy methods provided insight into non-volatile, solvent, and carrier-gas molecules in the molecular beam.
Humoral and cellular immune response to aMicrosporumcanisrecombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs (2003)

In order to better understand the host-fungus relationship in Microsporum canis dermatophytosis and to identify major fungal antigens, the immune response to a crude exoantigen preparation and to a purified recombinant keratinolytic metalloprotease (r-MEP3) was evaluated in guinea pigs experimentally infected with M. canis. Humoral and cellular immune responses were assessed from day 0 to day 57 post-infection (PI), the former by enzyme-linked immunosorbent assay (ELISA) and the latter via a lymphocyte proliferation assay. Infected guinea pigs developed humoral and cellular responses to both M. canis exoantigen and r-MEP3, while no specific immune response to these antigens was observed in control animals. This is the first report on the development of both humoral and cell-mediated immune responses to a purified keratinase in M. canis dermatophytosis.
Figure S5 from Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells (2023)

&lt;p&gt;Supplementary Figure 5. TASIN-1 induces apoptosis in HCT116 cells expressing truncated APC.&lt;/p&gt;
<title>Microlaser: a fundamental quantum generator of light</title> (1996)

We have achieved the first realization of a single atom microlaser, a laser oscillator with only one atom in an optical resonator. In the experiment a beam of two-level barium atoms traverses an ultrahigh Q single-mode cavity. The atoms are inverted by a (pi) -pulse field before they enter the cavity. Laser oscillation ((lambda) equals 791 nm) has been observed, with the mean number of atoms inside the mode &lt;N&gt; as small as 0.1, resulting in the mean number of photons in the mode &lt;N&gt; or 0.14. To understand the results quantitatively we used a fully-quantized one-atom microlaser theory adapted from its counterpart micromaser theory. The present theory was found to be in good agreement with the data for small &lt;N&gt; and &lt;n&gt;. Discrepancy between experiment and theory was observed for &lt;n&gt; very much greater than 1 and &lt;N&gt; approximately equal to 1. This discrepancy may be explained by the standing-wave nature of the cavity mode, in combination with the saturation effect occurring at large cavity photon number, as well as by the breakdown of single-atom interaction assumption in the theory for &lt;N&gt; greater than or equal to 1.
Structure-activity relationships of ?-conotoxins at N-type voltage-sensitive calcium channels (2000)

Due to their selectivity towards voltage-sensitive calcium channels (VSCCs) omega-conotoxins are being exploited as a new class of therapeutics in pain management and may also have potential application in ischaemic brain injury. Here, the structure-activity relationships (SARs) of several omega-conotoxins including GVIA, MVIIA, CVID and MVIIC are explored. In addition, the three-dimensional structures of these omega-conotoxins and some structurally related peptides that form the cysteine knot are compared, and the effects of the solution environment on structure discussed. The diversity of binding and functional assays used to measure omega-conotoxin potencies at the N-type VSCC warranted a re-evaluation of the relationship between these assays. With one exception, [A22]-GVIA, this analysis revealed a linear correlation between functional (peripheral N-type VSCCs) and radioligand binding assays (central N-type VSCCs) for the omega-conotoxins and analogues that were tested over three studies. The binding and functional results of several studies are compared in an attempt to identify and distinguish those residues that are important in omega-conotoxin function as opposed to those that form part of the structural scaffold. Further to determining what omega-conotoxin residues are important for VSCC binding, the range of possible interactions between the ligand and channel are considered and the factors that influence the selectivity of MVIIA, GVIA and CVID towards N-type VSCCs examined.
Bayesian Compressive Sensing via Belief Propagation (2008)

Compressive sensing (CS) is an emerging field based on the revelation that a small collection of linear projections of a sparse signal contains enough information for stable, sub-Nyquist signal acquisition. When a statistical characterization of the signal is available, Bayesian inference can complement conventional CS methods based on linear programming or greedy algorithms. We perform approximate Bayesian inference using belief propagation (BP) decoding, which represents the CS encoding matrix as a graphical model. Fast computation is obtained by reducing the size of the graphical model with sparse encoding matrices. To decode a length-N signal containing K large coefficients, our CS-BP decoding algorithm uses O(Klog(N)) measurements and O(Nlog^2(N)) computation. Finally, although we focus on a two-state mixture Gaussian model, CS-BP is easily adapted to other signal models.
Phenol/formaldehyde-derived macroporous carbon foams prepared with aprotic ionic liquid as liquid template (2012)

Herein, macroporous carbon foams were successfully prepared with phenol and formaldehyde as carbon precursors and an ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate (<TEX>$BMIPF_6$</TEX>), as a pore generator by employing a polymerization-induced phase separation method. During the polycondensation reaction of phenol and formaldehyde, <TEX>$BMIPF_6$</TEX> forms a clustered structure which in turn yields macropores upon carbonization. The morphology, pore structure, electrical conductivity of carbon foams were investigated in terms of the amount of the ionic liquid. The as-prepared macroporous carbon foams had around 100-150 <TEX>${\mu}m$</TEX>-sized pores. More importantly, the electrical conductivity of the carbon foams was linearly improved by the addition of <TEX>$BMIPF_6$</TEX>. To the best of the author's knowledge, this is the first result reporting the possibility of the use of an ionic liquid to prepare porous carbon materials.
CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity (2012)

Topoisomerase I is the target for a potent class of chemotherapeutic drugs derived from the plant alkaloid camptothecin that includes irinotecan and topotecan. In this study we have identified a novel site of CK2-mediated topoisomerase I (topo I) phosphorylation at serine 506 (PS506) that is relevant to topo I function and to cellular responses to these topo I-targeted drugs. CK2 treatment induced hyperphosphorylation of recombinant topo I and expression of the PS506 epitope, and resulted in increased binding of topo I to supercoiled plasmid DNA. Hyperphosphorylated topo I was approximately three times more effective than the basal phosphorylated enzyme at relaxing plasmid supercoils but had similar DNA cleavage activity once bound to DNA. The PS506 epitope was expressed in cancer cell lines with elevated CK2 activity, hyperphosphorylated topo I, and increased sensitivity to camptothecin. In contrast, PS506 was not detected in normal cells or cancer cell lines with lower levels of CK2 activity. By experimentally manipulating CK2 activity in cancer cell lines, we demonstrate a cause and effect relationship between CK2 activity, PS506 expression, camptothecin-induced cellular DNA damage, and cellular camptothecin sensitivity. Our results show that the PS506 epitope is an indicator of dysregulated, hyperphosphorylated topo I in cancer cells, and may thus serve as a diagnostic or prognostic biomarker and predict tumor responsiveness to widely used topo I-targeted therapies.
Table S1 from Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma (2023)

&lt;p&gt;Characteristics of human lung cancer cell lines used in this study and MTS assay data&lt;/p&gt;
A Novel Method for Targeted Gene Therapy in Ischemic Tissues through Viral Transfection of an Expression Cassette Containing Multiple Repetitions of Hypoxia Response Element (2009)

The authors' results confirm that AAV2 has in vitro tropism for skin-derived cell lines. Furthermore, HRE will drive gene expression in ischemia but not normoxia. This is the first step toward the authors' goal of HIF-1-regulated gene therapy to prevent ischemia related skin injury.
Scaling Properties of Well-Tiled PFCAs (2012)

Planar Fourier Capture Arrays (PFCAs) are imaging devices made from unmodified CMOS Angle-Sensitive Pixels (ASPs). PFCAs require no external imaging optics to photograph distant objects. Here, we explore PFCAs miniaturization in two analyses. First, we show an efficient method of tiling Fourier space with ASPs. Second, we show that the area of an optimally-tiled PFCA scales as the square of the effective number of pixels.
A conjecture concerning optimality of the Karhunen-Loeve basis in nonlinear reconstruction (2011)

We present a conjecture regarding the expectation of the maxima of $L^2$ norms of sub-vectors of a Gaussian vector; this has application to nonlinear reconstruction.
Azimuthal Spoke Propagation in Hall Effect Thrusters (2014)

Spokes are azimuthally propagating perturbations in the plasma discharge of Hall effect thrusters (HETs) that travel in the E x B direction. The mechanisms for spoke formation are unknown, but their presence has been associated with improved thruster performance in some thrusters motivating a detailed investigation. The propagation of azimuthal spokes are investigated in a 6 kW HET by using high-speed imaging and azimuthally spaced probes. The spoke velocity is determined from high-speed image analysis using three methods with similar results. The spoke velocity for three discharge voltages (300, 400, and 450 V) and three anode mass flow rates (14.7, 19.5, and 25.2 mg/s) are between 1500 and 2200 m/s across a range of magnetic field settings. The spoke velocity is inversely dependent on magnetic field strength for lower B-fields and asymptotes at higher B-fields. Spoke velocities calculated from the probes are consistently higher by 30% or more. An empirically approximated dispersion relation of ω <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">α</sup> = v <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ch</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">α</sup> k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">θ</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">α</sup> - ω <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ch</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">α</sup> where α ≥ 1 yields a characteristic velocity that matches the ion acoustic speed for N5 eV electrons which exist in the near-anode and near-field plume regions of the discharge.