gebhart/patrepeval huggingface dataset:
Development of a low pressure driven pneumatic actuator and its application to a robot hand (2006)

This paper presents a non-metallic and light robot hand that uses balloon-type pneumatic actuators that we developed. Recently, there has been a lot of research into robot coexisting with people and helping them. Such robots must be proven safe for contact with people. The drive system of our proposed robot hand uses balloon-type pneumatic actuators that we originally developed in consideration of the safety measures required for human contact. The results of test on the characteristics of the pneumatic actuator proved that it is possible to drive a robot hand and create enough generated force to grasp objects using lower inner pressure and lower air volume. Moreover, a model the same size as a human hand can be made without a big air compressor, we also consider the applications of such prosthetic hands
Anisotropic wetting and de-wetting of drops on substrates patterned with polygonal posts (2012)

We present results showing how water drops, produced by ink-jet printing, spread on surfaces patterned with lattices of diamond or triangular posts. Considering post widths typically ∼7 μm and lattice spacings between 15 and 40 μm, we observe drop shapes with 3, 4 and 6-fold symmetry, depending on both the symmetry of the lattice and the shape of the posts. This is a result of the different mechanisms of interface pinning and depinning which depend on the direction of the contact line motion with respect to the post shape. Lattice Boltzmann simulations are used to describe these mechanisms in detail for triangular posts. We also follow the motion of the contact line as the drops evaporate showing that they tend to return to their original shape. To explain this we show that the easy direction for movement is the same for spreading and drying drops. We compare the behaviour of small drops with that of larger drops created by jetting several drops at the same position. We find that the contact line motion is unexpectedly insensitive to drop volume, even when a spherical cap of fluid forms above the posts. The findings are relevant to micro-fluidic applications and to the control of drop shapes in ink-jet printing.
Suction and Oscillatory Blowing Interaction with Boundary Layers (2015)

This work presents ongoing experiments toward developing fundamental understanding of suction and oscillatory blowing (SaOB) flow control mechanisms along with development of accurate and practical CFD simulation methodologies for complex unsteady active flow control systems. Experimental and computational studies were conducted on SaOB actuators’ internal flow and external interaction with two zero pressure gradient boundary layers. The experimental work incorporates detailed multi component hot-wire measurements of both laminar and turbulent boundary layers with steady suction and pulsed blowing for a single actuator and an array configuration. Large eddy simulation was employed for the computational model. Simulations were carried out on the actuator internal flow, and the resulting oscillatory blowing jet exit velocity profiles are characterized and fit with a functional form, in order to create simplified boundary conditions for future flow control simulations. Both experimental and computational results show that the suction hole geometry and configuration is an important factor in determining the structure and stability of the downstream laminar as well as turbulent boundary layer flow-fields. Measurements of oscillatory blowing jets interacting with a turbulent boundary layer demonstrate this flow control produces unsteady spanwise and streamwise vorticity components that can be interpreted as counter-rotating streamwise vortex patterns.
Electron beam and optical proximity effect reduction for nanolithography: New results (2007)

Proximity effect correction by dose modulation is widely practiced in electron-beam lithography. Optical proximity control is also possible using a combination of shape adjustment and phase control. Assigning “the right” dose (or fill factor and phase for optics) is a well known mathematical inverse problem. Linear programming, by definition, is the appropriate method for determining dose. In the past, the technique was too slow for full-scale implementation in mask making. Here, the authors discuss how recent developments in computer speed and architecture have improved the prospects for full-scale implementation. In addition, the authors discuss some numerical techniques, analogous to gridding and relaxation, that make linear programming more attractive in mask making.
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor (2007)

The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues. We show that the HIF asparaginyl hydroxylase, factor inhibiting HIF (FIH), also catalyzes hydroxylation of highly conserved asparaginyl residues within ankyrin repeat (AR) domains (ARDs) of endogenous Notch receptors. AR hydroxylation decreases the extent of ARD binding to FIH while not affecting signaling through the canonical Notch pathway. ARD proteins were found to efficiently compete with HIF for FIH-dependent hydroxylation. Crystallographic analyses of the hydroxylated Notch ARD (2.35A) and of Notch peptides bound to FIH (2.4-2.6A) reveal the stereochemistry of hydroxylation on the AR and imply that significant conformational changes are required in the ARD fold in order to enable hydroxylation at the FIH active site. We propose that ARD proteins function as natural inhibitors of FIH and that the hydroxylation status of these proteins provides another oxygen-dependent interface that modulates HIF signaling.
Identification of Functional SNPs in BARD1 Gene and In Silico Analysis of Damaging SNPs: Based on Data Procured from dbSNP Database (2012)

Using the available bioinformatics tools and the data present in the dbSNP database, the four nsSNPs, rs4986841, rs111367604, rs13389423 and rs139785364, were identified as deleterious, reducing the protein stability of BARD1. Hence, these SNPs can be used for the larger population-based studies of female cancers.
Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods (2014)

This article is one of a series of 4 that reports on a task of the NanoRelease Food Additive project of the International Life Science Institute Center for Risk Science Innovation and Application to identify, evaluate, and develop methods that are needed to confidently detect, characterize, and quantify intentionally produced engineered nanomaterials (ENMs) released from food along the alimentary tract. This particular article focuses on the problem of detecting ENMs in food, paying special attention to matrix interferences and how to deal with them. In this review, an in-depth analysis of the literature related to detection of ENMs in complex matrices is presented. The literature review includes discussions of sampling methods, such as centrifugation and ENM extraction. Available analytical methods, as well as emerging methods, are also presented. The article concludes with a summary of findings and an overview of potential knowledge gaps and targets for method development in this area.
QSAR of multiple mutated antibodies (2007)

The aim of this study was to develop predictive quantitative structure-activity relationship (QSAR) modeling for antibody-peptide interactions. A small single chain antibody library was designed and manufactured around the murine anti-p24 (HIV-1) monoclonal antibody CB4-1 by use of statistical molecular design (SMD) principles and site directed mutagenesis, and its affinity for a p24 derived antigen was determined by fluorescence polarization. A satisfactory QSAR model (Q(2) = 0.74, R(2) = 0.88) was derived by correlating the affinity data to physicochemical property scales of the amino acids varied in the library. The model explains most of the antibody-antigen interactions of the studied set, and provides insights into the molecular mechanism involved in antigen binding.
Dual‐Curing of Waterborne Urethane‐Acrylate Coatings by UV and Thermal Processing (2003)

Abstract A waterbased dual‐cure urethane‐acrylate oligomer has been synthesized by polycondensation of monomers bearing hydroxyl, isocyanate and acrylate groups. To obtain a stable aqueous dispersion, carboxylate groups were grafted on the oligomer chain and the isocyanate groups were protected by a blocking agent. After water release by a brief heating, the dry films were cured either by a short UV exposure in the presence of a photoinitiator to induce the polymerization of the acrylate double bonds, or by heating up to 150 °C to release the isocyanates and promote the polycondensation by reaction with the hydroxyl groups, but mainly by a combination of UV and thermal cure. Both processes have been followed quantitatively by infrared spectroscopy to evaluate the influence of the temperature on the reaction rate and on the cure extent. The newly developed waterbased dual‐cure coatings were found to be quite resistant to accelerated weathering because of their aliphatic structure and their high crosslink density. Their light stability was substantially improved by the addition of a hydroxyphenyltriazine UV absorber and a hindered amine radical scavenger. Thermal curing of the dual‐cure waterborne PUA formulation at a temperature of 150 °C. magnified image Thermal curing of the dual‐cure waterborne PUA formulation at a temperature of 150 °C.
Exchange Asymmetries Incorrectly Interpreted as Evidence of Endowment Effect Theory and Prospect Theory? (2007)

Systematic asymmetries in exchange behavior have been widely interpreted as support for “endowment effect theory,” an application of prospect theory positing that loss aversion and utility function kinks set by entitlements explain observed asymmetries. We experimentally test an alternative explanation, namely, that asymmetries are explained by classical preference theories finding influence through the experimental procedures typically used. Contrary to the predictions of endowment effect theory, we observe no asymmetries when we modify procedures to remove the influence of classical preference theories. When we return to traditional-type procedures, however, the asymmetries reappear. The results support explanations based in classical preference theories and reject endowment effect theory. (JEL D01)
112. Strong Transgene-Specific Immune Responses Can Be Elicited with Novel Adeno-Associated Virus Vectors in Mice (2005)

Vectors based on recombinant adeno-associated virus (rAAV) have been widely appreciated for gene therapy application, in which the sustained expression of self-genes has been successfully achieved in a variety of animal models. However, the potential of rAAV vectors as vaccine carriers has only recently been recognized. We have isolated several novel AAV serotypes from primates i.e AAVs 7, 8, and 9. Therefore, it is of our interest to develop potential vaccines for human immunodeficiency virus type 1 (HIV-1) based on rAAV vectors of these new serotypes. We have constructed a panel of rAAV vectors based on different AAV serotypes (including AAV2/1, AAV2, AAV2/5, AAV2/7, AAV2/8, and AAV2/9), which all encoded HIV-1 gag p17 and p24 (designated as gagshort). BALB/c mice were i.m. immunized with this panel of AAVHIVgagshort vectors at the dose of E11 genome copies/mouse. 2, 3, and 4 weeks after immunization, splenocytes were harvested and stimulated with the H-2d restricted gag-specific CD8 T-cell epitope in intracellular IFN-g staining. Overall, AAV2/7 and AAV2/8 vaccine vectors elicited the highest levels of gag-specific CD8 T-cell responses; while AAV2/1 and AAV2/9 vaccine vectors were able to induce intermediate levels of gag-specific CD8 T-cell responses. Gag-specific CD8 T-cell responses induced with AAV2/5 and AAV2/2 vaccine vectors were barely detectable. In addition, serum samples from immunized mice were collected and total IgG responses to gag p24 were measured by ELISA. Overall, AAV2/7 and AAV2/9 vaccine vectors yielded the strongest IgG responses against p24; while AAV2/8, AAV2/1, and AAV2/5 vaccine vectors produced the intermediate IgG responses against p24. Surprisingly, there was no detectable p24-specific IgG response in serum samples from mice immunized with AAV2/2HIVgagshort vector, even though this vector yielded very high level of p24 expression in transduced cells in vitro. Interestingly, different patterns of p24-specific IgG1 vs IgG2a responses were observed in serum samples from mice immunized with HIVgagshort vaccine vectors based on different AAV serotypes. Furthermore, significant inflammation and infiltration in the mouse muscles injected with AAV2/7 and AAV2/8 vaccine vectors were observed at 4 weeks after i.m. injection by H/E staining. Taken together, these data suggested that strong transgene-specific immune responses can be elicited with novel rAAV vectors in mice. The immunogenicity of these vectors based on novel AAV serotypes will be examined in nonhuman primates.
New Silyl Ether Reagents for the Absolute Stereochemical Determination of Secondary Alcohols (2003)

[reaction: see text] Herein we report a new set of silyl ether reagents for determining the enantiomeric purity and absolute stereochemistry of secondary alcohols. These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol.
Phosphorylated Human Keratinocyte Ornithine Decarboxylase Is Preferentially Associated with Insoluble Cellular Proteins (1999)

Ornithine decarboxylase (ODC), the first enzyme in polyamine biosynthesis, is highly regulated by many trophic stimuli, and changes in its levels and organization correlate with cytoskeletal changes in normal human epidermal keratinocytes (NHEK). NHEK ODC exhibits a filamentous perinuclear/nuclear localization that becomes more diffuse under conditions that alter actin architecture. We have thus asked whether ODC colocalizes with a component of the NHEK cytoskeleton. Confocal immunofluorescence showed that ODC distribution in NHEK was primarily perinuclear; upon disruption of the actin cytoskeleton with cytochalasin D, ODC distribution was diffuse. The ODC distribution in untreated NHEK overlapped with that of keratin in the perinuclear but not cytoplasmic area; after treatment with cytochalasin D, overlap between staining for ODC and for keratin was extensive. No significant overlap with actin and minimal overlap with tubulin filament systems were observed. Subcellular fractionation by sequential homogenizations and centrifugations of NHEK lysates or detergent and salt extractions of NHEK in situ revealed that ODC protein and activity were detectable in both soluble and insoluble fractions, with mechanical disruption causing additional solubilization of ODC activity (three- to sevenfold above controls). Fractionation and ODC immunoprecipitation from [(32)P]orthophosphate-labeled NHEK lysates showed that a phosphorylated form of ODC was present in the insoluble fractions. Taken together, these data suggest that two pools of ODC exist in NHEK. The first is the previously described soluble pool, and the second is enriched in phospho-ODC and associated with insoluble cellular material that by immunohistochemistry appears to be organized in conjunction with the keratin cytoskeleton.
On the effect of artificial distortions on objective performance measures for dialog enhancement (2022)

The objective evaluation of dialog enhancement systems using computational methods is desired to complement the subjective evaluation using listening tests. It remains a challenge because for this application neither were performance measures specifically designed, nor were existing measures systematically analyzed. This work investigates eight objective performance measurement tools originally developed for audio and speech coding, speech enhancement, or source separation. To this end, a set of basic distortions is presented and used to simulate degradations that are common in dialog enhancement. The effect of the artificial distortions on the performance measures is quantified by means of a so-called response score that is proposed here.
Image inpainting using LLE-LDNR and linear subspace mappings (2013)

The paper first describes an examplar-based image inpainting algorithm using a locally linear neighbor embedding technique with low-dimensional neighborhood representation (LLE-LDNR). The inpainting algorithm first searches the K nearest neighbors ( ) of the input patch to be filled-in and linearly combine them with LLE-LDNR to synthesize the missing pixels. Linear regression is then introduced for improving the K-NN search. The performance of the LLE-LDNR with the enhanced K-NN search method is assessed for two applications: loss concealment and object removal.
Mammalian host defense peptides (2004)

1. Overview: antimicrobial peptides, as seen from a rear-view mirror R. I. Lehrer 2. Cationic antimicrobial peptides in regulation of commensal and pathogenic microbial populations D. A. Devine 3. Multiple functions of antimicrobial peptides in host immunity D. Yang and J. J. Oppenheim 4. Therapeutic potential and applications of innate immunity peptides T. J. Falla and L. Zhang 5. Mammalian ss-Defensins in mucosal defence G. Diamond, D. Laube and M. Klein-Patel 6. Biology and expression of the human cathelicidin LL-37 G. Gudmundsson and B. Agerberth 7. Antimicrobial peptides of the alimentary tract of mammals C. Bevins and T. Ganz 8. Antimicrobial peptides suppress microbial infections and sepsis in animal models K. A. Brogden, M. Ackermann, J. Zabner and M. J. Welsh 9. Bacterial structure and physiology: influence on susceptibility to antimicrobial peptides R. E. W. Hancock 9. The antifungal mechanisms of antimicrobial peptides E. J. Helmerhorst and F. G. Oppenheim 10. Antimicrobial peptides from platelets in defence against cardiovascular infections M. R. Yeaman 11. Mechanisms of bacterial resistance to antimicrobial peptides R. Tamayo, A. C. Portillo and J. S. Gunn 12. Roles of antimicrobial peptides in pulmonary disease R. Bals.
Supplementary Figure S2 from Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer (2023)

&lt;p&gt;Figure S2. HFF kinase exclusion plot&lt;/p&gt;
Effects of Transient and Persistent Anti-drug Antibodies to Certolizumab Pegol (2017)

This analysis demonstrates that persistent CZP-ADAb has negative effects on drug levels and efficacy, whereas transient expression may not. Serial measurements may be needed to characterize ADAb positivity. www.clinicaltrials.gov, Number NCT00160524.
Uncoupled Helmholtz resonator: An open photoacoustic cell (1985)

The results of acoustic and photoacoustic testing of an uncoupled Helmholtz resonator suggest its utilization as an open photoacoustic cell. Although signal levels are lower in our cell than in small closed cells, this type of resonator produces very low coherent noise if light scattering by the sample is negligible. The resonator is free of static pressure fluctuation problems as well.
Analysis of low power, low data rate ultra wideband impulse radio systems (2009)

During the last decade, ultra wideband (UWB) systems gained a large interest in the scientific world because of their suitability to realize among others communication systems with tremendous data rates and accurate indoor positioning and location systems. As a differing technology compared to classical narrowband radio transmission systems, UWB requires some novel approaches. Well established methods to develop and analyze narrowband transmission systems remain essentially valid but are not always well tailored or optimal to UWB systems. The need for novel approaches illuminates the reasons why there are still some uncovered topics in the literature, mainly related to the analyses of imperfections and perturbations during an UWB transmission. Consequently, this thesis attempts to cover some of these topics by theoretical studies, numerical simulations, as well as experimental verification.
Adhesion of Polyelectrolyte Microcapsules through Biotin−Streptavidin Specific Interaction (2006)

Adhesion of PAH/PSS and PDADMAC/PSS capsules through electrostatic and specific interactions has been investigated using reflective interference contrast microscopy (RICM). Adhesion of capsules via electrostatic interactions was found to be spontaneous and strong. Capsules functionalized with poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) did not exhibit significant adhesion (as determined by the adhesion area) to streptavidin-coated substrates, whereas capsules functionalized with biotinylated PLL-g-PEG showed a significantly larger adhesion area. Using continuum mechanical models, the total adhesion energies for these cases were calculated and were found to correspond to several tens of individual biotin-streptavidin pairs. The application of specific interactions such as the biotin-streptavidin system for controlled capsule adhesion has been demonstrated in this study.
The Effect Of Averaging Cardiac Doppler Spectrograms On Their Amplitude Variability (2005)

'The effect of averaging c ardiac Doppler spec t r o g ra nis on the i r a nip I it ude va r ia b i I it y was inlestigated in 30 patients. Pulsed-wave Doppler signals were recorded from the l eft v entricular o utflow t ract, approximatel! 1 cni below the a ortic valve for each patient. T he q uantification of. the a mplitude variability was performed by computing t he absolute value of the derivatil e function of each spectruni of the spectrograms. Results obtained over the systolic period showed rhar the reduction in the amplitude v ariabilit) is characterized by an exponentially decreasing curve. The reductions of the a mplitude variability for a number of cardiac cJcles equals to 5. IO. 15. and 20 were 23%. 36%. -I:?& and 46'%i, respecrii el!,.
Molecular cloning of a determinant coding for fimbrial antigen F1651, a Prs-like fimbrial antigen from porcine septicaemic Escherichia coli (1992)

The genetic determinant coding for F165(1) fimbriae was cloned from the chromosome of the porcine Escherichia coli wild-type strain 4787 (O115:K-:H51:F165). The fimbrial determinant was further subcloned into the BamHI site of pACYC184 and a restriction map was established. On Southern hybridization, identity between the chromosomally encoded prs-like determinant of strain 4787 and its cloned counterparts was demonstrated. The cloned F165(1) fimbriae and those of the wild-type strain possessed a major protein subunit of molecular mass 18.5 kDa. Strains expressing F165(1) fimbriae were detected using an F165-specific polyclonal antiserum and caused mannose-resistant haemagglutination and agglutination of Forssman latex beads. Antiserum against the cloned F165(1) fimbriae recognized a 18.5 kDa band in the parent strain 4787.