gebhart/patrepeval huggingface dataset:
Trial watch (2013)

Accumulating evidence suggests that the clinical efficacy of selected anticancer drugs, including conventional chemotherapeutics as well as targeted anticancer agents, originates (at least in part) from their ability to elicit a novel or reinstate a pre-existing tumor-specific immune response. One of the mechanisms whereby chemotherapy can stimulate the immune system to recognize and destroy malignant cells is commonly known as immunogenic cell death (ICD). Cancer cells succumbing to ICD are de facto converted into an anticancer vaccine and as such elicit an adaptive immune response. Several common chemotherapeutics share the ability of triggering ICD, as demonstrated in vaccination experiments relying on immunocompetent mice and syngeneic cancer cells. A large number of ongoing clinical trials involve such ICD inducers, often (but not always) as they are part of the gold standard therapeutic approach against specific neoplasms. In this Trial Watch, we summarize the latest advances on the use of cyclophosphamide, doxorubicin, epirubicin, oxaliplatin, and mitoxantrone in cancer patients, discussing high-impact studies that have been published during the last 13 months as well as clinical trials that have been initiated in the same period to assess the antineoplastic profile of these immunogenic drugs as off-label therapeutic interventions.
Electroless Copper Bath Stability Monitoring with UV-VIS Spectroscopy, pH, and Mixed Potential Measurements (2012)

Bath stability monitoring of electroless copper deposition has been done with different methods. A combination of UV-VIS spectra and pH measurement enabled us to determine the degradation of an electroless Cu solution. The pH of the Cu-containing solution gradually decreased as a function of time, while the UV-VIS absorbance increased. The decrease of pH is due to the consumption of OH− by the deposition reaction and the Cannizzaro reaction of glyoxilic acid. As application of these methods, the effect of the preparation sequence and bath stability was evaluated, bath break down was detected by the different methods used, and the potential for process monitoring was demonstrated. Furthermore, pH control during deposition was found to be very important to avoid defects in the electroless deposited seed layer, close to the via opening and top surface.
Ultrafast acoustoelectric imaging (2014)

Imaging the electrical activity of the body is central to the diagnosis of and treatment planning for some of our most pressing healthcare challenges, including heart and brain diseases. The acoustoelectric effect has recently been shown to provide contrast directly from current densities by measuring ultrasound-modulated electrical impedance in the heart. While promising, these approaches, based on focused emission at low frequency, result in limited signal-to-noise ratios (SNR), and temporal and spatial resolutions. In this study, we developed Ultrafast Acoustoelectric Tomography (UAT), based on plane wave emissions, which provides high frame rates and uniformly high spatial and temporal resolutions. We developed a novel reconstruction approach for UAT and demonstrated its feasibility in phantom experiments at current density levels similar to the ones occurring naturally in vivo, indicating that UAT could become a unique technique to map current density distributions in tissues and image their propagation at very high frame rates.
Kalman Filter SoC estimation for Li-Ion batteries (2011)

State-of-Charge (SoC) estimation is a key factor for correct and safe battery management, particularly for the development of the Battery Management System (BMS) [1]. The paper deals with this problem for the currently most promising technology in the battery filed: Lithium-Ion batteries. An electric model of the cell is identified and verified, in order to apply Kalman Filter Theory and design an algorithm for estimating SoC. Particularly the aim of the algorithm is to reject measurement noise and parametric uncertainties and be applicable to different cells of the same manufacturer and technology. In this purpose, design criterions that speed up the convergence time or make the estimation robust to noise measurements are presented. Results on two different cells of the same manufacturer and typology are shown, focusing on the different behaviors of the estimation due to different design choices.
Evaluation of helical wire inserts for CHF enhancement (2003)

The U.S. is evaluating helical wire inserts (HWI) for heat transfer enhancement and critical heat flux (CHF) performance in divertor cooling channels. This concept is attractive because it: (1) is cost-effective to integrate into parallel, gun-drilled channels using a simple brazing operation with no special tooling; (2) can accommodate selective placement where enhancement is most needed in long, curved channels, and (3) has been shown in past testing to reach CHF enhancement values comparable to swirl tape inserts. Two bare copper (CuCrZr, Elbrodur G) mock-ups were fabricated to determine the preferred combination of wire size and helix pitch for the 10-mm-diameter cooling channels selected by the U.S. One mock-up used 1-mm-dia. wire wound on a 5 and 10-mm pitch. The other used 1.5-mm-dia, wire wound on a 10 and 20-mm pitch. Each pitch extended over half the 200-mm length of the copper bar. The inserts were made from Inconel 600 wire and brazed to the channel wall at 980/spl deg/C using a Cu-Mn-Ni alloy. Gas-fan cooling was used after brazing to prevent undesired metallurgical reactions in the CuCrZr alloy and was followed by thermal aging to recover properties. CHF tests were performed in the 30-kW Electron-Beam Test System at Sandia using 100/spl deg/C and 130/spl deg/C subcooled, 4 MPa water flowing at 7 and 12 m/s. Coolant flow was reversed during testing so that each of the two wire pitches could be placed at the entrance end. Because the heated length is short near CHF levels, thermocouple locations were selected so local effects of the wire insert wrap beneath the heated surface could be evaluated.
Multihormonal Control of Pre-Pro-Somatostatin mRNA Levels in the Periventricular Nucleus of the Male and Female Rat Hypothalamus (1990)

The influence of sex steroids as well as the possible involvement of dopaminergic pathways in the modulation of pre-pro-somatostatin (SS) mRNA levels was investigated by quantitative in situ hybridization in the hypothalamic periventricular nucleus (PeN) in adult male and female rats. In situ hybridization was performed using a [35S]-labeled cDNA probe encoding pre-proSS mRNA. Gonadectomy performed 14 days earlier decreased the mean number of silver grains/neuron corresponding to the relative pre-proSS mRNA levels by 22% in male and by 18-28% in female rats. A 14-day treatment with the nonaromatizable androgen dihydrotestosterone (DHT) increased the mean number of silver grains/neuron by 34-40% in gonadectomized animals of both sexes. Moreover, administration of 17 beta-estradiol (E2, 0.25 microgram twice daily) increased pre-proSS mRNA levels by 40% in ovariectomized (OVX) animals. Such treatment with E2 or DHT changed the frequency distribution profile of the hybridization signal intensity, thus increasing the percentage of highly labeled neurons (greater than or equal to 61 grains/neuron) by 10 to 12-fold. A 14-day treatment with the D2 dopamine receptor agonist bromocriptine (BRO) increased pre-proSS mRNA levels by 15 and 28% in intact female and OVX animals, respectively, while the dopaminergic antagonist haloperidol (HAL) decreased the value of this parameter by 20 and 30%. Furthermore, BRO increased pre-proSS mRNA levels by 10 and 20% in intact and castrated male rats, respectively, whereas HAL decreased pre-proSS mRNA levels by 25 and 14% in the same groups of animals. Administration of E2 in combination with HAL in OVX animals increased pre-proSS mRNA levels by 70% compared to those measured in OVX animals treated with HAL alone. In HAL-treated castrated male rats, administration of DHT increased the relative pre-proSS mRNA levels by 35% compared to those measured in castrated animals treated with HAL alone. The present data clearly demonstrate that androgens and estrogens as well as dopamine-mediated mechanisms could play a regulatory role in pre-proSS mRNA levels in somatostatinergic neurons in the hypothalamic PeN in both male and female rats.
Answering three questions about networking research (2022)

Researchers often talk about specific technical trends or research topics. But we rarely talk about how and why we do the research that we do. The process of submitting and reviewing papers puts our ideas through a particular kind of filter that may make all of the research seem like it follows some standard rubric, a SIGCOMM Normal Form if you will. During a panel at HotNets'21, five researchers---Hari Balakrishnan, Jon Crowcroft, Jennifer Rexford, Scott Shenker, and David Tennenhouse---each answered three questions about how they pick their own research topics, what areas they would like to see more research on, and how they evaluate conference papers. Due to the unexpectedly positive response to that panel, CCR will be publishing a series of answers to these three questions, starting with two participants from the panel but reaching out to others to provide answers from a broader cross-section of the SIGCOMM community.
Correction to “Access to Cyclopropyl-Fused Azacycles via a Palladium-Catalyzed Direct Alkenylation Strategy” (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Access to Cyclopropyl-Fused Azacycles via a Palladium-Catalyzed Direct Alkenylation Strategy"Carolyn L. LaddCarolyn L. LaddMore by Carolyn L. Ladd and André B. Charette*André B. CharetteMore by André B. Charettehttps://orcid.org/0000-0001-5622-5063Cite this: Org. Lett. 2022, 24, 25, 4715Publication Date (Web):June 16, 2022Publication History Received2 June 2022Published online16 June 2022Published inissue 1 July 2022https://pubs.acs.org/doi/10.1021/acs.orglett.2c01874https://doi.org/10.1021/acs.orglett.2c01874correctionACS PublicationsCopyright © 2022 American Chemical Society. This publication is licensed under these Terms of Use. Request reuse permissions This publication is Open Access under the license indicated. Learn MoreArticle Views676Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (590 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characteristics of Ce-Doped ZrO[sub 2] Dielectric Films Prepared by a Solution Deposition Process (2010)

The microstructural and electrical properties of sol–gel deposited ultrathin films with different Ce contents (, 0.1, 0.3, and 0.5) were studied using various characterization tools. Ce doping reduced the crystallization (densification) temperature and increased the dielectric constant of the film. There was no degradation of the hysteresis characteristics, and a systematic negative shift in the flatband voltage was observed by incorporating Ce atoms. Leakage current measurements showed no detrimental effects of Ce doping up to , and the conduction mechanism analyses revealed that the films follow a Poole–Frenkel (PF) conduction, exhibiting a systematic increase in the linear slope of the PF plot possibly due to the decrease in dielectric trap sites with increasing Ce content.
Glass: A New Media for a New Era? (2018)

In the foreseeable future, major cloud vendors will need to store multiple zettabytes of data in their cloud storage infrastructure. Like all storage, cloud storage systems need to trade performance for cost, and they currently achieve this by using storage tiers backed by different storage media. The ultimate goal for cloud storage would be to provide zero-cost storage with low access latencies and high throughput. But all the storage media being deployed in the cloud today were created before the cloud existed, and were designed to support many usage scenarios. With cloud storage, the focus is on cost, and storage needs to be designed to be right-provisionable. The limits of what is possible with existing storage technologies are being reached, and a new clean-slate approach is needed for cloud storage. Hence, the time is right to seek out a new physical media to underpin novel storage systems designed exclusively to support the cloud. In Project Silica, Microsoft Research and Southampton University, are exploring whether quartz glass could be the future media for mass storage in the cloud. In this paper, we describe the basis for the technology, and discuss conventional assumptions about storage that we are challenging in Project Silica.
Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers (2011)

In 2005, the American Chemical Society (ACS) Green Chemistry Institute (GCI) and global pharmaceutical companies established the ACS GCI Pharmaceutical Roundtable to encourage the integration of green chemistry and engineering into the pharmaceutical industry. The Roundtable developed a list of key research areas in green chemistry in 2007, which has served as a guide for focusing green chemistry research. Following that publication, the Roundtable companies have identified a list of the key green engineering research areas that is intended to be the required companion of the first list. This publication summarizes the process used to identify and agree on the top key green engineering research areas and describes these areas, highlighting their research challenges and opportunities for improvements from the perspective of the pharmaceutical industry.
Long-Term Cancer-Specific and Overall Survival for Men Followed More Than 10 Years After Primary and Salvage Cryoablation of the Prostate (2010)

The long-term results of prostate cryotherapy in our series indicate an 87% overall 10-year prostate-cancer-specific survival, despite early cryotherapy technology and the majority of patients being D'Amico high risk.
Engineering pro-angiogenic biomaterials via chemoselective extracellular vesicle immobilization (2021)

Nanoscale extracellular vesicles (EVs) represent a unique cellular derivative that reflect the therapeutic potential of mesenchymal stem cells (MSCs) toward tissue engineering and injury repair without the logistical and safety concerns of utilizing living cells. However, upon systemic administration in vivo,EVs undergo rapid clearance and typically lack controlled targeted delivery, thus reducing their effectiveness in therapeutic regenerative therapies. Here, we describe a strategy that enables long-term in vivo spatial EV retention by chemoselective immobilization of metabolically incoporated azido ligand-bearing EVs (azido-EVs) within a dibenzocyclooctyne-modified collagen hydrogel. MSC-derived azido-EVs exhibit comparable morphological and functional properties as their non-labeled EV counterparts and, when immobilized within collagen hydrogel implants via click chemistry, they elicited more robust host cell infiltration, angiogenic and immunoregulatory responses including vascular ingrowth and macrophage recruitment compared to ten times the higher dose required by non-immobilized EVs. We envision this technology will enable a wide range of applications to spatially promote vascularization and host integration relevant to tissue engineering and regenerative medicine applications.
Growth in Agarose of Human Cells Infected with Cytomegalovirus (1974)

After infection by human cytomegalovirus (CMV), human diploid fibroblasts could grow in agarose medium for several generations. Clones of infected cells grew for weeks, although in every case they ultimately underwent lysis owing to the cytopathic effect of the virus. Virus was inoculated at high dilution and after UV irradiation in an effort to derive cells infected with noninfectious defective particles still capable of inducing cell stimulation. Dilute or irradiated virus occasionally yielded large colonies of replicating cells, although permanent transformation was not observed. One clone derived from UV-CMV-infected cells was passaged four times before undergoing lysis. During these passages the cells exhibited alterations in morphology and orientation.
Fault diagnosis for mixed-signal electronic systems (1999)

In this paper, we propose an efficient methodology to diagnose faults in complex mixed-signal systems. The proposed technique combines the advantages of simulation-before-test and simulation-after-test approaches. Given a faulty circuit, a hierarchical fault dictionary (a list of all faulty behaviors of the circuit, used for fault location) is used to locate the faulty component. The computational requirements during fault dictionary construction are minimized by hierarchical fault clustering and behavioral fault modeling. The resulting fault dictionary is most compact in size and contains complete diagnostic accuracy. Once the faulty component is identified, a novel parameter identification algorithm determines the values of the parameters corresponding to the faulty component. The proposed approach minimizes the off-line computation required by a fault dictionary technique as well as the online computation that is typical of a simulation-after-test technique. It is also robust to component tolerances and measurement inaccuracies, as the precise values of the parameters are determined. Finally, the proposed fault diagnosis technique can diagnose a faulty component at any level of design hierarchy, or identify the exact value of the faulty parameters, according to the intended resolution of diagnosis.
Antioxidant Activities of a New Lignan and a Neolignan from Saururus chinensis. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Concentric spectrometer forms enabled by lithographically produced gratings (2004)

Advances in blazed grating fabrication through electron-beam and x-ray lithography are presented, which allow the realization of concentric spectrometer forms with highly desirable properties covering a wide variety of applications, from airborne and spaceborne imaging spectroscopy to in-situ Raman or reflectance microspectroscopy. Design examples and experimental results are shown.
LIA (Liver Shear Stiffness, INR, Etiology) Score Predicts Risk of Further Decompensation in Patients with Decompensated Cirrhosis (2023)

In patients who have been clinically diagnosed with decompensated cirrhosis (DC), progression to more advanced decompensation is associated with high mortality. Therefore, the early detection of the risk of further decompensation is helpful to formulate individual treatment and follow-up schedules for patients with DC. Liver stiffness is a potential prognosis biomarker for patients with cirrhosis. This study evaluated MR elastography (MRE) as a tool to predict the risk of further decompensation. By integrating MRE-assessed liver stiffness with clinical information, we developed a risk score that is valuable for predicting further decompensation in patients with DC.
High frequency resonators with wide bandwidth using SH<inf>0</inf> mode plate wave in thin LiNbO<inf>3</inf> (2013)

Currently, an ultrawide band resonator used for a tunable filter with a wide tunable range is strongly required, because a mobile phone with multi-bands and a cognitive radio system require such a tunable filter to simplify their wirelss front-end circuits. The authors developed resonators with ultrawide bandwidths of 26% to 29% and large impedance ratios of 92 to 98 dB between resonance (fr) and anti-resonance frequencies (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> ) using a 0-th shear horizontal (SH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) mode plate wave in a 28-30°YX-LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plate. However, the resonators were of low frequency as f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> = 1.8 MHz and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> = 2.3 MHz and suffer from ripples due to transverse mode between f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sub> . In this study, high frequency SH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> mode plate wave resonators (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> = 440 ~ 560 MHz) with a wide bandwidth and a large impedance ratio and without ripples have been fabricated using an ultrathin LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plate and an apodized interdigital transducer.
Synthesis, Calpain Inhibitory Activity, and Cytotoxicity of P2-Substituted Proline and Thiaproline Peptidyl Aldehydes and Peptidyl α-Ketoamides (2006)

Calpain is a cytosolic cysteine endopeptidase that has been implicated in a number of disorders including cancer. We have synthesized and studied the mu-calpain inhibitory activity and cytotoxicity of peptidyl aldehydes and peptidyl alpha-ketoamides with N-substituted D-proline or L-thiaproline residues at the P2-postion. The most potent and most selective members of the series were (R)-1-(4-nitrophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide (1j) and (R)-1-(4-iodophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide (1n). The compounds inhibited mu-calpain with Ki values of 0.02 microM and 0.03 microM, respectively, and displayed over 180-fold (1j) and 130-fold (1n) greater affinity for mu-calpain compared to cathepsin B. The cytotoxic effect of the compounds was evaluated in two leukemia cell lines (Daudi and Jurkat) and three solid tumor cell lines (DU-145, PC-3, and HeLa). Generally the compounds were modestly cytotoxic and displayed no correlation between the cytotoxic activity and mu-calpain inhibition.