gebhart/patrepeval huggingface dataset:
Priming and stimulation of hepatitis C virus-specific CD4+ and CD8+ T cells against HCV antigens NS4, NS5a or NS5b from HCV-naive individuals: implications for prophylactic vaccine (2007)

Hepatitis C virus (HCV) is a devastating human pathogen, yet there is no vaccine available for this virus. From studies with acute or chronic HCV-infected humans and chimpanzees, T-cell responses against HCV-derived conserved non-structural antigens have been correlated with viral clearance. In this study, recombinant adenoviral vectors containing HCV-derived NS4, NS5a or NS5b genes were employed to endogenously express the HCV antigens in human dendritic cells (DCs). The DCs expressing these HCV antigens exhibited normal phenotype and function. Intriguingly, we found that the DCs expressing HCV NS4, NS5a or NS5b antigens were able to significantly stimulate autologous T cells obtained from uninfected healthy individuals. These T cells produced various cytokines and proliferated in an HCV antigen-dependent manner. Evidence of both CD4(+) and CD8(+) T-cell responses generated in vitro against HCV NS4, NS5a or NS5b were obtained. HCV NS4 was much less stimulatory for CD4(+) and CD8(+) T cells than NS5. Further, in secondary assays, the CD4(+) T cells primed in vitro exhibited HCV antigen-specific proliferative responses against recombinant protein antigens. In summary, we provide conclusive evidence of in vitro stimulation of CD4(+) and CD8(+) T cells from HCV-naive individuals against HCV antigens NS4, NS5a and NS5b. The studies with naive T cells represent early events in the induction of cellular immune responses, which most likely govern the outcome of HCV infection. These studies have significant implications in designing vaccines for HCV infection in both prophylactic and therapeutic settings.
The potential of a CLIA-certified prognostic/predictive molecular test to address the rising costs of non-small cell lung cancer. (2020)

e21671 Background: Treating recurrences of non-small cell lung cancer (NSCLC) is increasingly expensive but still rarely curative. Disease free survival (DFS) among resected stage I-IIA patients remains only 50-70%. Guidelines advocate adjuvant therapy in “high-risk” patients in this population to reduce these costly and deadly recurrences, but recognize that conventional criteria have not been validated to stratify risk or predict benefit. A CLIA-certified, commercially available 14-gene expression risk profile (DetermaRx) has been extensively validated among stage I-IIA non-squamous NSCLC patients; prospective data now suggest that the test predicts improved DFS with adjuvant therapy. We therefore studied the potential economic impact of this molecular test on early stage NSCLC. Methods: Model variables included: relative increase in DFS with adjuvant treatment of molecular intermediate- and high-risk patients (25.5%; range 12.3-41.3%); cost of adjuvant ($8,760; $8,144-$9,376) or late-stage ($284,500; $224,900-345,200) treatment; and compliance with recommendations for adjuvant therapy (75%; 60-90%). Ranges were based on: historical trials and recent prospective data, published cost literature, and published survey data, respectively. Parameters were varied in a multifactorial, one-way sensitivity analysis to assess the impact of parameter uncertainty. Results: Reduction of recurrences with implementation of the 14-gene assay resulted in an average cost savings of $11,608/patient (potential systems savings of ~$450 million), even when including the cost of molecular risk stratification ($4000/patient) and of cisplatin-based adjuvant chemotherapy for molecular high- and intermediate-risk patients. Lower bound assumptions for relative improvement, cost of care, and compliance yielded persistent savings of $3,699, $8,091 and $8,486, respectively. Conclusions: Utilization of this predictive molecular risk stratification assay in the management of stage I-IIA non-squamous NSCLC has the potential to significantly reduce lung cancer costs in an era of targeted therapy and immunotherapy, while at the same time improving DFS and saving lives.
Fragmentation of Human Erythrocyte Ghosts and Their Application as a Carrier of Heme Complex (1984)

Abstract Human erythrocyte ghosts were taken into fragments by sonication. The average radius of the fragmented ghosts gradually decreased with the sonication time. The fragmented ghosts were obtained as spheres and reached to about 0.1 μm. In spite of the change in radius, their membrane fluidity was the same as that of the unsonicated ghost membrane. The [meso-α,α,α,α-tetrakis(o-pivalamidophenyl)porphinato]iron(III)-mono (1-dodecyl-2-methylimidazole) complex was incorporated into the hydrophobic region of the fragmented ghost membrane. This hybrid showed a semistable oxygen adduct in pH 7.0 phosphate buffer solution.
Participation of Minorities in Cost-share Programs-The Experience of a Small Underserved Landowners’ Group in Alabama (2013)

This article highlights aspects of the historical, social and policy developments of cost-share programs in the USA. The experiences of African Americans who are members of Limited Resource Landowners Education Network in attempting to access available cost-share resources in Alabama are presented. Literature reviews, participation in and response to the USDA’s Cooperative Conservation Partnership Initiative (CCPI), and discussions with stakeholders were the primary sources of information and data used in this exploratory analysis which was conducted within the framework of a “modified action research model”. Until recently underserved landowners’ participation in cost-share programs in Alabama has been very limited. Although in theory access has been open to underserved landowners, these landowners have historically encountered a range of challenges in trying to participate in the cost-share programs. Many of those challenges, the analysis has indicated, stemmed from: (a) Natural Resource Conservation Service’s (NRCS’) limited pool of available and relevant technical personnel, (b) the agency’s interpretation of existing program policy guidelines and (c) the low level of underserved landowners’ trust and confidence in the transparency and fairness of federal and state agencies and their officials. Successfully navigating such obstacles and challenges during the implementation of the CCPI initiative in Alabama necessitated much understanding, perseverance, collaboration, and a willingness to compromise by all project stakeholders. Strategies likely to assist other similar groups in successfully navigating the various Federal and State requirements for participation in cost-share programs are proposed. Lessons learned will inform future application of the action research model in this continuing study.
Fall in total cholesterol concentration over five years in association with changes in fatty acid composition of cooking oil in Mauritius: cross sectional survey (1996)

Dietary changes that entailed a reduction in the saturated fat content of a ubiquitous cooking oil explained most of the observed decrease in serum cholesterol concentration over five years in the population of Mauritius.
EasyGroups (2012)

We present a touch and proximity based method for binding a group of mobile devices into an ecosystem for collaborative interactions. We aim to provide a seamless user experience by integrating the binding method with the application start-up flow. Our method also determines the order of the devices, allowing implementation of spatial interactions.
Facies Simulation in Practice: Lithotype proportion mapping and Plurigaussian Simulation, a powerful combination (2012)

4 Abstract Geostatistical simulation of facies has become part of the mainstream workflow when building stochastic geocellular models. However, modelers are presented with a plethora of challenges when attempting to produce models based on real data, including honoring depositional facies boundary conditions and their proportions, honoring data in the presence of numerous or closely spaced wells, capturing post depositional overprinting, and accounting for non- stationarity. These challenges often require unavailable tools and even the lack of modeling skills. Although the technology has evolved during the past 60 years and many sophisticated techniques exist, only of a few of the methods are available in commercial software. The most commonly used facies modeling algorithms tend to satisfy some but not all of these issues, but fall short on many more. Sequential Indicator simulation, the most popular method, lacks the ability to honor facies boundary conditions, Truncated Gaussian Simulation handles simple facies transitional boundaries, and while Object Simulation manages most non-overprinted complex facies sets, but it is unstable in the presence of numerous or closely spaced wells. Non-stationarity compounds the problem and a simple detrending of the data often results in an unsatisfactory solution. One powerful combination of methodologies is the use of a Lithotype Proportion Matrix with pixel-based facies simulation algorithms. There are a numerous advantages to this
First clinical case of effective medical treatment of the vitreoretinal traction with recovery of the visual acuity. (2010)

This case-report evaluates the effectiveness of the medical treatment on vitreomacular traction through the use of palmitoylethanolamide (PEA), orally administered. Our 69 year-old patient reported a significant eyesight reduction, metamorphopsia and photopsia. He underwent the following investigations, before and after medical treatment: visual acuity evaluation, dilated fundus examination, OCT. The treatment consisted of the administration of two tablets of PEA per day over 7 days. We observed that, while the visual acuity in the right eye was 2/10 compared to the initial 11/10, the dilated fundus examination highlighted a foveal hole. Moreover, the OCT confirmed the presence of a vitreomacular traction due to the incomplete posterior vitreous detachment. At the end of the treatment with PEA, the visual acuity was equal to 8/10 and the OCT showed a disappearance of the hyperreflective streak with recovery of the physiological retinal and foveal profile. The therapy was eventually carried on for 10 more days with a final visual acuity of 10/10. In conclusion, PEA orally administered, beyond a rare possibility of a spontaneous resolution of the vitreomacular traction, probably contributed, by anti inflammatory action, to the vitreolysis and thus to the disappearance of the vitreomacular traction and foveal hole with a subsequent recovery of the eyesight and of the metamorphopsia.
ChemInform Abstract: Synthesis and Optical Resolution of (R)‐ and (S)‐trans‐7‐Hydroxy‐2‐(N‐ propyl‐N‐(3′‐iodo‐2′‐propenyl)amino)tetralin: A New D3 Dopamine Receptor Ligand. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
88 Genetic association between vitiligo genetic susceptibility and response to immune-checkpoint inhibitortherapy in advanced melanoma patients (2022)

<h3>Background</h3> Only ~50% of advanced melanoma patients show objective responses to immune checkpoint inhibitor (ICI) therapy. Currently, there are still no reliable predictive biomarkers explaining ICI response heterogeneity. Vitiligo development during ICI therapy is associated with a better prognosis in melanoma patients. Genetic susceptibility to vitiligo has been well-characterized using multiple large GWAS studies, and includes genes that are also associated to other autoimmune diseases. <h3>Objective</h3> To test if the germline genetic association to vitiligo is able to predict response to ICI in patients with advanced melanoma. <h3>Methods</h3> Data from &gt;1,000 patients from 6 melanoma centers in the Netherlands participating in the international IO-GEM melanoma consortium were analyzed in this study. DNA was extracted from blood or saliva and genotyped by Illumina GSA MD v3.0. Clinical data was obtained from the Dutch Melanoma Treatment Registry. We developed a polygenetic vitiligo-susceptibility score using a pre-defined set of 54 vitiligo-associated single nucleotide polymorphisms (SNPs) predicting overall survival. <h3>Results</h3> We found a significant protective relation of the unweighted vitiligo-susceptibility score to all-cause mortality. Weighted for the association to vitiligo, the vitiligo-susceptibility score outperformed the unweighted score in predicting all-cause mortality. <h3>Conclusions</h3> These results suggest that genetic susceptibility to vitiligo may be associated with more favorable survival outcome in melanoma patients upon ICI treatment. The risk scores will be validated in the remaining part of IO-GEM.
Data-driven Modeling of Li-ion Battery based on the Manufacturer Specifications and Laboratory Measurements (2022)

Having a good model for a Li-ion battery is essential in the development and testing of state estimation and lifetime prediction algorithms. The desired features of the model include flexibility, fast development, accuracy and reliability. There are many different ways to model a battery, depending on the level of abstraction desired, the data available and the target simulation environment. In this paper we focus on how to build a battery model using a data-driven approach. We present two different ways of creating the model: using datasheets provided by the manufacturer and using more extensive laboratory measurements. This hybrid method of using lab data on datasheet battery model is named here as advance datasheet battery model. We present a thorough report on the successful preparation of the data to be used in both models, and highlight the benefits and the disadvantages of both approaches. Furthermore, we show how the measurements-based advanced datasheet battery model is more robust to model battery behavior with 100% improvement in modeling accuracy compared to a pure datasheet based approach.
Performance evaluation of discrete Raman amplifiers in coherent transmission systems (2022)

We evaluate the performance penalty due to discrete Raman amplifier (DRA) in a long haul WDM transmission system. The investigation was primarily performed to study the impact of the accumulated nonlinear noise due to fibre chromatic dispersion and nonlinear coefficient(γ). Nonlinear fibres such as inverse dispersion fibre (IDF), dispersion compensation fibre (DCF) and a development fibre known as the Corning Raman fibre (CRF) with the opposite sign of CD to the other two, were taken as the gain fibre in the DRA stage of the long-haul transmission setup. To study the performance penalty with these Raman gain fibres a 30 GBaud 120 Gb/s DP-QPSK channel @1550 nm was combined with 9 spectrally shaped 50 GHz amplified spontaneous emission (ASE) channels for transmission over a recirculation loop with a per loop length of 63 km single mode fibre (SMF). Our modelling and experimental results show that a fibre with positive dispersion >10ps/nm/km and a nonlinear coefficient of ∼ 4W<sup>-1</sup>km<sup>-1</sup> is a good choice of gain fibre for DRA-assisted coherent transmission system.
Ethylene polymerization catalysts from supported organotransition metal complexes. II. Chromium alkyls (1990)

Abstract Another class of organochromium compounds, beta‐stabilized chromium alkyls, has been synthesized and tested for catalytic activity in ethylene polymerization. Although not active alone, these compounds do exhibit remarkable activity when reacted with a partially dehydroxylated high surface area carrier. The best supports seem to be fluorided alumina or the aluminophosphates, depending on the particular chromium alkyl being tested. The worst was always silica. Both divalent and tetravalent chromium alkyls were tested and found to have high catalytic activity. Comparisons of activity and polymer structure were made between these compounds and previously studied organochromium compounds with pi‐bonded ligands.
Impact of Pressure Recovery in the Evaluation of the Omnicarbon™ Tilting Disc Valve (2006)

Doppler echocardiography does not allow for pressure recovery, which is a significant phenomenon in the hemodynamic function of the Omnicarbon tilting disc valve. Valve performance is much better than expected from Doppler gradients.
Organics in Photonics: Advances and Roadmap (2005)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text L. Eldada, "Organics in Photonics: Advances and Roadmap," in Frontiers in Optics, OSA Technical Digest Series (Optica Publishing Group, 2005), paper SThB3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Bidirectional Multiple Charge Transfer Active Pixel Image Sensor for Low-Power Focal Plane Motion Vector Estimation (2001)

This paper proposes a CMOS image sensor with high-speed non-destructive image sensing mode using bidirectional multiple charge transfer active pixels. The proposed image sensor is suitable for low-power focal plane motion vector estimation using iterative block matching while maintaining the image quality of video-rate (33ms/frame) pictures and the accuracy of the motion vector estimation. The performances of the bidirectional multiple charge transfer active pixel sensor are evaluated by circuit simulations and the proper operation of the sensor is confirmed by experiments.
Abstract 1666: Regorafenib (BAY 73-4506): preclinical pharmacology and clinical identification and quantification of its major metabolites (2010)

Abstract Regorafenib is a novel diphenylurea oral multikinase inhibitor of angiogenic, stromal, and oncogenic kinases with potent preclinical antitumor activity and long-lasting antiangiogenic activity (as measured by dynamic contrast-enhanced magnetic resonance imaging). Regorafenib treatment has recently shown to result in a 31% partial response (PR) rate and 50% stabilization rate in patients with metastatic renal cell carcinoma in a Phase II study. Promising clinical activity was shown in a Phase I study in 27 evaluable patients with advanced refractory colorectal cancer (median 4 prior regimens) with a 74% overall disease control rate (PR + stable disease). The biotransformation of regorafenib was investigated in vitro with liver microsomes and hepatocytes, and in vivo in the plasma of several species. In man, the N-oxide (M-2) and the demethylated N-oxide (M-5) appear significant as both metabolites show systemic exposure (area under the curve [AUC], mg*h/L) at steady state similar to regorafenib (the parent compound) in patients at a dose of 160 mg in a 3 weeks on/1 week off Phase I study. Characterization of both M-2 and M-5 demonstrated potent pharmacologic activities. In biochemical kinase assays, M-2 and M-5 showed an inhibition profile similar to but distinct from regorafenib. In cellular assays, M-2 and M-5 inhibited key targets such as vascular endothelial growth factor (VEGF) receptor 2, TIE-2, and mutant and wild-type c-KIT and B-RAF, with IC50 values very similar to regorafenib for M-2 and somewhat higher for M-5. Regorafenib and both M-2 and M-5 dosed iv at 1 mg/kg showed significant activity in a rat VEGF hypotensive pharmacodynamic model. Both metabolites dosed orally exhibited potent dose-dependent tumor growth inhibition (TGI) in preclinical murine HT-29 colorectal and MDA-MB-231 breast cancer xenografts, achieving significant TGI of 62/58% and 54/50%, respectively, compared with vehicle controls at 10 mg/kg. Regorafenib revealed 66-77% TGI at 10 mg/kg in these models. On oral administration of regorafenib to mice, the N-oxide (M-2) plasma level accounted for ∼20% of the AUC of regorafenib; conversely, on administration of M-2, regorafenib exposure reached ∼20% of M-2 exposure, indicating that oxidation to and reduction of the N-oxide are metabolic pathways in vivo. In summary, these data demonstrate that the metabolites M-2 and M-5, exhibiting similar exposure as regorafenib, their parent compound, in man, are pharmacologically active and therefore most likely contribute to the clinical antitumor activity of regorafenib. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1666.
Demand and Interference Aware Adaptive Resource Management for High Throughput GEO Satellite Systems (2022)

The scarce spectrum and power resources, the inter-beam interference, together with the high traffic demand, pose new major challenges for the next generation of Very High Throughput Satellite (VHTS) systems. Accordingly, future satellites are expected to employ advanced resource/interference management techniques to achieve high system spectrum efficiency and low power consumption while ensuring user demand satisfaction. This paper proposes a novel demand and interference aware adaptive resource management for geostationary (GEO) VHTS systems. For this, we formulate a multi-objective optimization problem to minimize the total transmit power consumption and system bandwidth usage while matching the offered capacity with the demand per beam. In this context, we consider resource management for a system with full-precoding, i.e., all beams are precoded; without precoding, i.e., no precoding is applied to any beam; and with partial precoding, i.e., only some beams are precoded. The nature of the problem is non-convex and we solve it by jointly using the Dinkelbach and Successive Convex Approximation (SCA) methods. The simulation results show that the proposed method outperforms the benchmark schemes. Specifically, we show that the proposed method requires low resource consumption, low computational time, and simultaneously achieves a high demand satisfaction.
Spatio-Temporal Distribution of Vector-Host Contact (VHC) Ratios and Ecological Niche Modeling of the West Nile Virus Mosquito Vector, Culex quinquefasciatus, in the City of New Orleans, LA, USA (2017)

The consistent sporadic transmission of West Nile Virus (WNV) in the city of New Orleans justifies the need for distribution risk maps highlighting human risk of mosquito bites. We modeled the influence of biophysical and socioeconomic metrics on the spatio-temporal distributions of presence/vector-host contact (VHC) ratios of WNV vector, <i>Culex quinquefasciatus</i>, within their flight range<i>.</i> Biophysical and socioeconomic data were extracted within 5-km buffer radii around sampling localities of gravid female <i>Culex quinquefasciatus</i>. The spatio-temporal correlations between VHC data and 33 variables, including climate, land use-land cover (LULC), socioeconomic, and land surface terrain were analyzed using stepwise linear regression models (RM). Using MaxEnt, we developed a distribution model using the correlated predicting variables. Only 12 factors showed significant correlations with spatial distribution of VHC ratios (<i>R</i>² = 81.62, <i>p</i> < 0.01). Non-forested wetland (NFWL), tree density (TD) and residential-urban (RU) settings demonstrated the strongest relationship. The VHC ratios showed monthly environmental resilience in terms of number and type of influential factors. The highest prediction power of RU and other urban and built up land (OUBL), was demonstrated during May-August. This association was positively correlated with the onset of the mosquito WNV infection rate during June. These findings were confirmed by the Jackknife analysis in MaxEnt and independently collected field validation points. The spatial and temporal correlations of VHC ratios and their response to the predicting variables are discussed.