gebhart/patrepeval huggingface dataset:
Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome (2018)

Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and ADMET properties, and its ability to improve upon memory performance in a mouse model of FXS, Fmr1<sup>-/-</sup> mice. This small molecule demonstrates good brain penetrance, low-nanomolar potency for the inhibition of HDAC6 (IC<sub>50</sub> = 2.3 nM), with at least a thousand-fold selectivity over all other class I, II, and IV HDAC isoforms. Moreover, through its inhibition of the α-tubulin deacetylase domain of HDAC6 (CD2), in cells SW-100 upregulates α-tubulin acetylation with no effect on histone acetylation and selectively restores the impaired acetylated α-tubulin levels in the hippocampus of Fmr1<sup>-/-</sup> mice. Lastly, SW-100 ameliorates several memory and learning impairments in Fmr1<sup>-/-</sup> mice, thus modeling the intellectual deficiencies associated with FXS, and hence providing a strong rationale for pursuing HDAC6-based therapies for the treatment of this rare disease.
The limitation of electrode shape on the operational speed of a carbon nanotube based micro-supercapacitor (2017)

We demonstrate the influence of the electrode shape on the operational speed of a micro-supercapacitor.
Probe lifetime around natural satellites with obliquity (2022)

Abstract The dynamics of a probe orbiting a moon can be significantly influenced by the non-coincidence between the moon’s equatorial and orbital planes. Thus, we performed a general analysis about the effects of the angle (obliquity) between the above-mentioned planes and of the angle (nodal phasing) between the nodal lines of the mother planet’s apparent orbit and the probe orbit on the lifetime of the probe. The lifetime, strictly correlated to the variations in eccentricity of the probe orbit, was evaluated starting from low values of the semi-major axis, moderate eccentricity, and high inclination to offer high ground spatial resolution and extend latitudinal coverage of the natural satellite. This investigation, carried out through numerical simulations, may be useful for identifying the optimal initial conditions of the probe’s orbit elements, leading to an important increase in the probe lifetime in missions devoted to the exploration of natural satellites.
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: Part 1 polymer relaxation phenomena (2022)

Abstract To investigate the contributions of polymer relaxation phenomena to the mechanism of disperse dye adsorption on poly(ethylene terephthalate) fibres, a commercial grade dye was applied to poly(ethylene terephthalate) fabric at temperatures between 30°C and 130°C. Three regions of temperature‐dependent dyeing behaviour were identified, in which the promotional effect imparted by increasing dyeing temperature varied, depending on whether dyeing had been carried out at temperatures that were below, within or above the polymer's glass transition temperature, T g , namely &lt; 65°C, between 65°C and 110°C and between 110°C and 130°C, respectively. When experimentally determined colour strength data points (log 1/ f k ) were fitted to plots of polymer structural relaxation (log a T ) calculated using the Williams, Landel and Ferry equation as a function of ( T − T g ), three different levels of correspondence were achieved which paralleled the observed three regions of temperature‐dependent dye uptake. The adsorption of the commercial disperse dye on the poly(ethylene terephthalate) fibre therefore concurs with the free volume model of dye diffusion insofar as the diffusional behaviour of the dye is related to the relaxation time of the molecular motions occurring within the poly(ethylene terephthalate) polymer. The finding that the poly(ethylene terephthalate) substrate's glass transition extends over a broad range of temperature upto ~110°C explains why elevated dyeing temperatures in the region of 130/140°C must be used in High Temperature dyeing processes, and also, why ~75% of uptake of the commercial disperse dye on the poly(ethylene terephthalate) fabric occurs over the very narrow 20‐30°C critical temperature range between 110 and 130°C/140°C.
Method to distinguish ferroelectric from nonferroelectric origin in case of resistive switching in ferroelectric capacitors (2008)

We present investigations on the resistive switching effect in SrRuO3∕PbZr0.2Ti0.8O3∕Pt ferroelectric capacitors. Using a conductive atomic force microscope, the out-of-plane piezoelectric response and the capacitive and resistive current were simultaneously measured as a function of applied bias voltage. We observed two independent switching phenomena, one attributed to the ferroelectric switching process and the other to resistive switching.We show that I-V curves alone are not sufficient in ferroelectric materials to clarify the underlying switching mechanism and must be used with sufficient caution.
Correction to: Upadacitinib improves patient-reported outcomes in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: results from SELECT-NEXT (2020)

An amendment to this paper has been published and can be accessed via the original article.
Chemically Synthesized Oligosaccharides, 1994. A Searchable Table of Glycosidic Linkages. (1995)

Abstract This review of the literature on oligosaccharide synthesis tabulates over 700 glycosidic linkages that have been chemically synthesized in the “popular literature” in the year 1994. The “popular literature” consists of the following journals, most frequently used for reporting oligosaccharide synthesis: Acta Chem. Scand., Angew. Chem. Intl. Ed. Engl., Aust. J. Chem., Bioorg. Med. Chem., Bioorg. Med. Chem. Lett., Bull. Chem. Soc. Jpn., Bull. SOC. Chim. Fr., Can. J. Chem., Carbohydr. Res., Carbohydr. Lett., Chem. Ber., Chem. Lett., Chem.-Ztg., Gazz. Chim. Ital., Glycoconjugate J., Glycobiology, Helv. Chim. Acta, Heterocycles, J. Am. Chem. Soc., J. Carbohydr. Chem., J. Chem. Res., J. Chem. Soc. Chem. Commun., J. Chem. Soc. Perkin Trans. I, J. Med. Chem., J . Org. Chem., Liebigs Ann. Chem., Pol. J. Chem., Rec. Trav. Chim. Pays Bas., Synlett, Synthesis, Synth. Commun., Tetrahedron and Tetrahedron Lett.
Supplementary Data 1-2 from Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated <i>Listeria monocytogenes</i> (2023)

Supplementary Data 1-2 from Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated &lt;i&gt;Listeria monocytogenes&lt;/i&gt;
Adaptive Algorithm for Engine Air – Fuel Ratio Control with Dual Fuel Injection Systems (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Dual fuel injection systems, like PFI+DI (port fuel injection + direct injection system) are being increasingly used in gasoline engine applications to increase the engine performance, fuel efficiency and reduce emissions. At a given engine operating condition, the air/fuel error is a function of the fraction of fuel injected by each of the fuel systems. If the fraction of fuel from each of the fuel system is changed at a given operating condition, the fuel system error will change as well making it challenging to learn the fuel system errors.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper aims at describing the adaptive fueling control algorithm to estimate the fuel error contribution from each individual fuel system. Considering the fuel injection system slope errors to be the significant cause for air-fuel errors, a model structure was developed to calculate the fuel system adaptive correction factor as a function of changing fraction of fueling between the fuel systems. A recursive least squares estimation strategy was used to accurately estimate the individual fuel system correction factors and the same was implemented in real time on 3.5L GTDI engine. Algorithm was validated on different applications of dual fuel injection systems by inducing known amount of fueling errors on individual fuel systems (40% lean to 40% rich fueling faults). The results describe offline validation of the fueling correction model and the real time validation of the strategy. This real time estimation and control of the fueling errors from individual fuel system, significantly improves the air-fuel control of the dual fuel injection engines. This methodology additionally helps diagnose and separate each fuel system failure.&lt;/div&gt;&lt;/div&gt;
Role of molecules in tunneling-current-induced photon emission from the surface of a perinone derivative molecular monolayer on Au(100) (2003)

The role of molecules in tunneling current induced photon emission from luminescent molecules on metal surfaces is still an open issue despite the recent observation of molecular fluorescence. We found that at low tunneling currents (1 nA), the molecular fluorescence from the surface of a perinone derivative (PD) molecular monolayer on Au(100) is completely quenched through non-radiative energy dissipation to the Au substrate. The PD molecular monolayer acts as a spacer to modify the tip-induced plasmon modes, enhance the intensity of the plasmon-mediated emission, and cause a blueshift of the emission spectra. However, at relatively high tunneling currents $(1\mathrm{nA}{I}_{t}\ensuremath{\sim}5\mathrm{nA}),$ broadened emission spectra were observed, which suggests that molecular fluorescence may be feasible upon further decoupling of the PD molecular electronic states from the metal substrate.
Toshiba BRIDJE at NTCIR-6 CLIR: The Head/Lead Method and Graded Relevance Feedback (2008)

At NTCIR-6 CLIR, Toshiba participated in the Monolingual and Bilingual IR tasks covering three topic languages (Japanese, English and Chinese) and one document language (Japanese). For Stage 1 (which is the usual ad hoc task using the new NTCIR-6 topics), we submitted two DESCRIPTION runs and two TITLE runs for each topic language. Our first search strategy is Selective Sampling with Memory Resetting, and our second one is the Head/Lead method, which uses the Selective Sampling run as one of the components for data fusion. According to the Relaxed and Rigid Mean Average Precision statistics released by the organisers, we are the top performer in all six subtasks. For Stage 2 (which reused the NTCIR-3, 4 and 5 test collections), we repeated our two Stage 1 strategies in order to enable analysis across all four test collections. Moreover, we conducted some unofficial true relevance feedback experiments by exploiting the graded relevance data provided in the test collections. Our automatic run results show that the Head/Lead method slightly but consistently improves performance, while our unofficial “interactive ” run results suggest that graded-relevance metrics favour graded relevance feedback while Average Precision favours binary relevance feedback. In addition, our significance tests suggest that the NTCIR-6 Japanese test collection is “harder ” than previous collections.
ZnO Modified High Aspect Ratio Carbon Electrodes for Hydrogen Sensing Applications (2011)

Design, fabrication, and testing results of a hydrogen gas sensor based on a surface modified high density and high aspect ratio 3-D carbon post microarray are described in this paper. After the conversion of photoresist patterns into carbon electrodes, the increased surface was conformally coated with a metal oxide semiconductor film by atomic layer deposition (ALD). A maximum sensitivity as high as 100 (Rair/ Rhydrogen) has been observed in the fabricated sensor even in the presence of moisture at low temperature. A fast initial response (90% resistance drop in 30 sec at 3000 ppm hydrogen) of the sensor could be utilized for early leak detection. The methodology of surface modification as well as the test result shows good promise for various chemical sensing devices based on the proposed strategy.
Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease (2015)

We did not demonstrate efficacy of vercirnon as an induction therapy in patients with moderately-to-severely active Crohn's disease; its effect in maintenance therapy was not addressed.
Endoscopic autofluorescence micro-spectroimaging of alveoli: comparative spectral analysis of amiodarone-induced pneumonitis patients and healthy smokers (2011)

Fibered confocal fluorescence microscopy (FCFM) with spectroscopic analysis capability was used during bronchoscopy, at 488nm excitation, to record autofluorescence images and associated emission spectra of the alveoli of 5 healthy smoking volunteers and 7 non-smoking amiodarone-induced pneumonitis (AIP) patients. Alveolar fluorescent cellular infiltration was observed in both groups. Our objective was to assess the potential of spectroscopy in differentiating these two groups. Methods: We previously demonstrated that in healthy smokers alveolar elastin backbone and tobacco tar contained in macrophages contribute to the observed signal. Each normalized spectrum was modeled as a linear combination of 3 components: S<sub>exp</sub>(&lambda;) = C<sub>e</sub>.S<sub>e</sub>(&lambda;)+C<sub>t</sub>.S<sub>t</sub>(&lambda;)+C<sub>G</sub>.S<sub>G</sub>(&lambda;), C<sub>e</sub>, C<sub>t</sub> and C<sub>G</sub> are amplitude coefficients. S<sub>e</sub>(&lambda;) and S<sub>t</sub>(&lambda;) are respectively the normalized elastin and tobacco tar emission spectra measured experimentally and S<sub>G</sub>(&lambda;) a gaussian spectrum with tunable width and central wavelength. Levenbergt-Marquardt algorithm determined the optimal set of coefficients. Results: AIP patient autofluorescence spectra can be uniquely modelized by the linear combination of the elastin spectrum (C<sub>e</sub> = 0.61) and of a gaussian spectrum (center wavelength 550nm, width 40nm); the tobacco tar spectrum coefficient C<sub>t</sub> is found to be zero. For healthy smoking volunteers, only two spectral components were considered: the tobacco tar component (C<sub>t</sub> = 1,03) and the elastin component (C<sub>e</sub> = 0). Conclusion: Spectral analysis is able to distinguish cellular infiltrated images from AIP patients and healthy smoking volunteers. It appears as a powerful complementary tool for FCFM.
A Probabilistic Theory of Deep Learning (2015)

A grand challenge in machine learning is the development of computational algorithms that match or outperform humans in perceptual inference tasks that are complicated by nuisance variation. For instance, visual object recognition involves the unknown object position, orientation, and scale in object recognition while speech recognition involves the unknown voice pronunciation, pitch, and speed. Recently, a new breed of deep learning algorithms have emerged for high-nuisance inference tasks that routinely yield pattern recognition systems with near- or super-human capabilities. But a fundamental question remains: Why do they work? Intuitions abound, but a coherent framework for understanding, analyzing, and synthesizing deep learning architectures has remained elusive. We answer this question by developing a new probabilistic framework for deep learning based on the Deep Rendering Model: a generative probabilistic model that explicitly captures latent nuisance variation. By relaxing the generative model to a discriminative one, we can recover two of the current leading deep learning systems, deep convolutional neural networks and random decision forests, providing insights into their successes and shortcomings, as well as a principled route to their improvement.
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers (2018)

The receptor tyrosine kinase rearranged during transfection (RET) is an oncogenic driver activated in multiple cancers, including non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and papillary thyroid cancer. No approved therapies have been designed to target RET; treatment has been limited to multikinase inhibitors (MKI), which can have significant off-target toxicities and limited efficacy. BLU-667 is a highly potent and selective RET inhibitor designed to overcome these limitations. <i>In vitro</i>, BLU-667 demonstrated ≥10-fold increased potency over approved MKIs against oncogenic RET variants and resistance mutants. <i>In vivo</i>, BLU-667 potently inhibited growth of NSCLC and thyroid cancer xenografts driven by various <i>RET</i> mutations and fusions without inhibiting VEGFR2. In first-in-human testing, BLU-667 significantly inhibited RET signaling and induced durable clinical responses in patients with <i>RET</i>-altered NSCLC and MTC without notable off-target toxicity, providing clinical validation for selective RET targeting.<b>Significance:</b> Patients with <i>RET</i>-driven cancers derive limited benefit from available MKIs. BLU-667 is a potent and selective RET inhibitor that induces tumor regression in cancer models with <i>RET</i> mutations and fusions. BLU-667 attenuated RET signaling and produced durable clinical responses in patients with <i>RET</i>-altered tumors, clinically validating selective RET targeting. <i>Cancer Discov; 8(7); 836-49. ©2018 AACR.</i><i>See related commentary by Iams and Lovly, p. 797</i><i>This article is highlighted in the In This Issue feature, p. 781</i>.
An active contraction model of the valvular interstitial cell (2016)

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Metal–Organic Framework Regioisomers Based on Bifunctional Ligands (2011)

Regioisomeric MOFs: A series of bifunctional metal–organic framework (MOF) regioisomers has been produced from amino-halo benzene dicarboxylate (NH2X-BDC) ligands. ZrIV- and ZnII-based MOFs were synthesized and for the flexbile ZnII-based MOFs, gas sorption properties were dependent on the ligand substitution pattern. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Real‐World Assessment of Acute Left Ventricular Lead Implant Success and Complication Rates: Results from the Attain Success Clinical Trial (2016)

This study represents the largest prospective evaluation of LVL implantation to date, revealing a high LVL implant success rate and low complication rate using a single family of leads and delivery catheters.
The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading (1999)

Heparin-binding epidermal-like growth factor (HB-EGF) is synthesized as a transmembrane precursor (HB-EGF(TM)). The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGF(TM) results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF. To analyze mechanisms that regulate HB-EGF shedding, a stable cell line was established expressing HB-EGF(TM) in which the ectodomain and the cytoplasmic tail were tagged with hemagglutinin (HA) and Myc epitopes, respectively (HB-EGF(TM)HA/Myc). HB-EGF(TM)HA/Myc cleavage was followed by the appearance of soluble HB-EGFHA in conditioned medium, the loss of biotinylated cell-surface HB-EGF(TM)HA/Myc, and the appearance of a Myc-tagged cytoplasmic tail fragment in cell lysates. By using this approach, several novel metalloproteinase-dependent regulators of HB-EGF(TM) shedding were identified as follows. (i) HB-EGF(TM)HA/Myc shedding induced by PMA was blocked by the mitogen-activated protein (MAP) kinase kinase inhibitor, PD98059. PMA activated MAP kinase within 5 min, but HB-EGF(TM)HA/Myc shedding did not occur until 20 min, suggesting that MAP kinase activation was a necessary step in the pathway of PMA-induced HB-EGF(TM) cleavage. (ii) Activation of an inducible Raf-1 kinase, DeltaRaf-1:estrogen receptor, resulted in a rapid MAP kinase activation within 10 min and shedding of HB-EGF(TM)HA/Myc within 20-40 min. (iii) Serum induced MAP kinase activation and HB-EGF(TM)HA/Myc shedding that were inhibited by PD98059. (iv) Whereas PMA induced HB-EGF(TM)HA/Myc shedding in attached cells, no shedding occurred when the cells were placed in suspension. Shedding was fully restored shortly after cells were allowed to spread on fibronectin, and the extent of PMA-induced shedding increased with the extent of cell spreading. PMA induced the same level of MAP kinase activation whether the cells were attached or in suspension suggesting that although MAP kinase activation might be necessary for shedding, it was not sufficient. Taken together, these results suggest that there are two components of cell regulation that contribute to the shedding process, not previously recognized, the Raf-1/MAP kinase signal transduction pathway and cell adhesion and spreading.
Enhanced anti-windup compensation for the dual stage hard disk drive systems with amplitude saturation (2016)

Enhanced anti-windup (AW) schemes are designed for the dual stage hard disk drive (HDD) system to solve the amplitude saturation problem of the secondary actuator. The sensitivity decoupling approach is used for designing the nominal linear controllers for the dual stage HDD systems. The AW compensators for the system are synthesized by solving a linear matrix inequality optimization. The AW scheme is further enhanced with a filter, which can be designed by the robust control methodologies. The proposed schemes and an existing AW scheme are evaluated and compared by simulation on a dual stage HDD benchmark control problem with white noise vibration disturbance.
Application of substrate curvature method to differentiate drying stresses in topical coatings and human stratum corneum (2010)

Despite the extensive use of topical coatings in cosmetics, their effect on the mechanical properties of human skin and the perception of skin tightness in the form of drying stresses is not well understood. We describe the application of a recently developed substrate curvature technique to characterize stresses in drying and non-drying occlusive topical coatings. We then extend the technique to measure the combined effects of the coating applied to human stratum corneum (SC) where the overall drying stresses may have contributions from the coating, the SC and the interaction of the coating with the SC. We show how these separate contributions in the coating and SC layers can be differentiated.