gebhart/patrepeval huggingface dataset:
Immunogenic and Antigenic Epitopes of Immunoglobulins Binding of Human Monoclonal Anti‐D Antibodies to FcRI on the Monocyte‐Like U937 Cell Line (1988)

Seventeen human monoclonal IgG1- or IgG3 anti-D-secreting clones have been examined for their ability to sensitise O+ red cells for Fc-receptor-mediated rosette formation with U937 cells. IgG3 but not IgG1 anti-D antibodies were able to mediate stable rosette formation with unstimulated U937 cells via interaction with the FcRI receptor. Decreasing FcRI density by incubating U937 cells with di-butyryl cAMP almost completely abolished rosette formation, whilst increasing FcRI density by incubating U937 cells with interferon-gamma increased the percentage of cells forming rosettes with IgG3- and IgG1-sensitised red cells. These data suggest that rosette formation between IgG anti-D-sensitised red cells and FcRI-expressing cells is dependent upon the density of IgG3 on the red cell surface, the density of FcRI on the effector cell, multiple FcRI/IgG interactions are required for stable rosette formation and that more FcRI/IgG1 than FcRI/IgG3 interactions are required.
Combining feature-based and model-based approaches for robust ellipse detection (2016)

Fast and robust ellipse detection is a vital step in many image processing and computer vision applications. Two main approaches exist for ellipse detection, i.e., model-based and feature-based. Model-based methods require much more computation, but they can perform better in occlusions. Feature-based approaches are fast but may perform insufficient in cluttered cases. In this study, we propose an hybrid method which combines both approaches to accelerate the process without compromising accuracy. We extract elliptical arcs to narrow down search space by obtaining seeds for prospective ellipses. For each seed arc, we compute a limited search region consisting of hypothetical ellipses that each can be formed with that seed. Later, we vote them on the edge image to determine best hypothesis among the all, if exists. We tested the proposed algorithm on a public dataset and promising results are obtained compare to state of the art methods in the literature.
Multi-channel notch filter based on a phase-shift phase-only sampled fiber Bragg grating (2008)

We propose a novel method for the implementation of a tunable multi-channel notch filter based on a thermally induced phase-shift phase-only sampled fiber Bragg grating (FBG). The proposed method is numerically and experimentally demonstrated. A 51-channel notch filter with a bandwidth (FWHM) of 0.026 nm and a tuning range of 0.6 nm has been achieved. This proposed technique offers the potential applications to the multiwavelength fiber laser and multi-channel all optical logic devices.
Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19 (2023)

The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID-19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necessitates very large doses and places a substantial burden on the healthcare system. In contrast, direct inhaled delivery of mAb therapeutics offers the convenience of self-dosing at home, as well as much more efficient mAb delivery to the respiratory tract. Here, building on our previous discovery of Fc-mucin interactions crosslinking viruses to mucins, we showed that regdanvimab, a potent neutralizing mAb already approved for COVID-19 in several countries, can effectively trap SARS-CoV-2 virus-like particles in fresh human airway mucus. IN-006, a reformulation of regdanvimab, was stably nebulized across a wide range of concentrations, with no loss of activity and no formation of aggregates. Finally, nebulized delivery of IN-006 resulted in 100-fold greater mAb levels in the lungs of rats compared to serum, in marked contrast to intravenously dosed mAbs. These results not only support our current efforts to evaluate the safety and efficacy of IN-006 in clinical trials, but more broadly substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS-CoV-2 and other respiratory pathologies.
Correction: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules (2017)

Correction for ‘On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules’ by Ali Q. Alorabi <italic>et al.</italic>, <italic>Lab Chip</italic>, 2017, DOI: 10.1039/c7lc00918f.
Monitoring the human posture in industrial environment: A feasibility study (2018)

This paper describes a method that can be used to monitor the human posture in industrial environment. The method is based on the simultaneous use of a 3D camera (Microsoft Kinect V2) and a wearable motion capture system that uses inertial measurement units to identify the body posture (Notch Wearable). The data fusion at feature level allows overcoming the intrinsic limitations of the two methods, deriving from occlusions and electromagnetic interferences, respectively. This work describes the algorithms implemented for the data validation, the calibration of the two measurement systems performed in controlled environment and experiments performed in tailoring operations. The first step of our analysis was the implementation of algorithms used to validate the skeleton measured by the Microsoft Kinect, that is unreliable in presence of occlusions. The calibration of the Kinect and Notch systems was performed by asking to different subjects to repeat movements of the upper limbs and evaluating the measurements repeatability and reproducibility. Finally, experiments were performed in different tailoring operations and the cumulative probability density function of different body angles was evaluated to compute the biomechanical loads of the workers.
Novel ways of depositing ZnTe films by a solution growth technique (1991)

Cu-doped ZnTe films, <1000{Angstrom}, were reproducibly deposited for the first time by an electrochemical method. A CdTe/CdS/ITO/glass substrate is externally short circuited to a zinc counter electrode in an aqueous bath consisting of ZnCl{sub 2} and TeO{sub 2} to complete an electrochemical cell. Control of both pH and TeO{sub 2} concentration was necessary to deposit single phase ZnTe films. A copper complex was added to the bath to control the ZnTe conductivity and dope the films p-type. CdTe/CdS solar cells using the ZnTe:Cu as the primary contact to the CdTe have achieved efficiencies of {approximately}9%. 15 refs., 7 figs., 2 tabs.
Increased amphetamine-induced hyperactivity in translin (Tsn) KO mice is driven by elevated adiposity (2020)

Abstract The translin/trax microRNA-degrading enzyme mediates activity-induced changes in translation that underlie several long-lasting forms of cellular plasticity. As translin and trax are expressed in dopaminergic and striatal neurons, we proceeded to investigate whether deletion of Tsn blocks amphetamine sensitization, a long-lasting, translation-dependent form of behavioral plasticity, Although we expected constitutive Tsn deletion to impair amphetamine sensitization, we found, instead, that it enhances the hyperlocomotion produced by the initial dose of amphetamine. Since these mice display elevated adiposity, which alters pharmacokinetics of many drugs, we measured brain amphetamine levels in Tsn knockout mice and found that these are elevated. We also found that diet-induced increases in adiposity in WT mice correlate with elevated brain amphetamine levels. As amphetamine and its analogues are widely used to treat attention deficit disorder, which is associated with obesity, further studies are needed to assess the impact of adiposity on amphetamine levels in these patients.
Hybrid nanoparticle biomarkers in Near-Field Optical Microscopy (2011)

We report Near Field Optical Microscopy and spectroscopy of hybrid nanoparticles. They exhibit luminescence properties suitable for their use as biological markers. A direct application is demonstrated: Hybrid Nanoparticle Biosensors.
Topological and Geometrical Synthesis of Three-Degree-of-Freedom Fully Parallel Manipulators by Instantaneous Kinematics (2008)

This paper presents a new synthesis procedure of fully parallel manipulators (PMs) of three degrees of freedom (DOFs) that could be implemented in a computer-aided synthesis process. Possible designs of PMs are represented by a set of unit joint twists at an initial configuration, called here topological and geometric parameters (TGPs). This makes it possible to represent PMs of all topologies and geometries in an easy and consistent way. The kinematic bond between the end effector (EE) and the base is then formulated as a set of equations involving TGPs, actuated-joint variables, and non-actuated-joint variables (passive joints). To achieve the required type of EE motion, possible topologies are first derived from tangent space analysis, and then the feasible topologies are retained by further displacement analysis. The geometries are determined such that the set of equations should be isoconstrained when passive-joint variables are taken as unknowns. The synthesis procedure of 3DOF PMs is illustrated with three numerical examples: one producing a new architecture of one translation and two rotations, while the other two producing existing architectures of translational PMs.
Reaction of crosslinked chloromethyl polystyrene with 1,4-butanedithiol: site-site interactions and their control (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of crosslinked chloromethyl polystyrene with 1,4-butanedithiol: site-site interactions and their controlM. Jean Farrall and Jean M. J. FrechetCite this: J. Am. Chem. Soc. 1978, 100, 25, 7998–7999Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://pubs.acs.org/doi/10.1021/ja00493a033https://doi.org/10.1021/ja00493a033research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
De novo 1q32q44 duplication and distal 1q trisomy syndrome (2003)

We report on an infant with minor anomalies and a de novo 1q duplication. The chromosomal abnormality was diagnosed prenatally after sonographic detection of cerebral ventriculomegaly and bilateral choroid plexus cysts in the fetus. The amniocentesis showed an abnormal male karyotype, 46,XY,dup(1)(q32q44), subsequently confirmed by fluorescence in situ hybridization using whole chromosome paint 1 and comparative genomic hybridization. The baby, born at 37 weeks of gestation, had wide cranial sutures and large fontanelles, sloping forehead, hypertelorism, short and downward-slanting palpebral fissures, a high-arched and narrow palate, malformed ears, and long feet with overriding second and third toes. This is the sixth case of known duplication involving the 1q32q44 segment; the physical findings in the case reported herein are similar to those of other patients reported previously, providing further evidence of the existence of the "distal 1q trisomy" phenotype.
Scalable optical switch fabric for avionic networks (2006)

An optical packet switch fabric for avionic networks is described. The switch core uses waveguide grating routers (WGRs) and star couplers, i.e. only passive optical components. The only active switching elements are tunable lasers located at the transmitters. A switching time of 5 ns is experimentally demonstrated.
Performance Evaluation for ML Sequence Detection in ISI Channels with Gauss Markov Noise (2010)

Inter-symbol interference (ISI) channels with data dependent Gauss Markov noise have been used to model read channels in magnetic recording and other data storage systems. The Viterbi algorithm can be adapted for performing maximum likelihood sequence detection in such channels. However, the problem of finding an analytical upper bound on the bit error rate of the Viterbi detector in this case has not been fully investigated. Current techniques rely on an exhaustive enumeration of short error events and determine the BER using a union bound. In this work, we consider a subset of the class of ISI channels with data dependent Gauss-Markov noise. We derive an upper bound on the pairwise error probability (PEP) between the transmitted bit sequence and the decoded bit sequence that can be expressed as a product of functions depending on current and previous states in the (incorrect) decoded sequence and the (correct) transmitted sequence. In general, the PEP is asymmetric. The average BER over all possible bit sequences is then determined using a pairwise state diagram. Simulations results which corroborate the analysis of upper bound, demonstrate that analytic bound on BER is tight in high SNR regime. In the high SNR regime, our proposed upper bound obviates the need for computationally expensive simulation.
Fiber Optic Links For Airborne Satellite Communication Applications (1988)

We report the first implementation of fiber optics at 11 GHz in an experimental satellite communication EHF/SHF research terminal for airborne applications. Signal-to-noise and bit-error-rate were measured to characterize the system after a 100-m-long fiber optic link replaced a 4 ft long coaxial cable to enable X-band signal remoting.
Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma (2006)

Concurrent administration of EWS/FLI-1 antisense oligonucleotides and rapamycin efficiently induced the apoptotic death of EWS cells in culture through a process involving transforming growth factor-beta. In vivo experiments conclusively showed that the combined treatment with antisense oligonucleotides and rapamycin caused a significant inhibition of tumor growth in mice. These results provide proof of principle for further exploration of the potential of this combined therapeutic modality as a novel strategy for the treatment of tumors of the Ewing's sarcoma family.
A Photogenerated Silicon Plasma Waveguide Switch and Variable Attenuator for Millimeter-Wave Applications (2021)

This article reports the design, fabrication, and measurement of a millimeter-wave (mm-wave) solid-state <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\pi $ </tex-math></inline-formula> -match waveguide switch using bulk silicon micromachining. A photogenerated plasma within a silicon post is utilized as the switching element within the waveguide channel. Not only does this isolate the switch bias network from the RF signal path but also allows for tuning of the OFF-state isolation with increasing optical power for application as a variable attenuator. A measured OFF-state isolation greater than 25 dB up to 40 GHz is reported, with a measured extracted ON-state insertion loss of 0.52 dB at 35 GHz, and less than 0.88 dB across the entire band from 30 to 40 GHz. The proposed switch illustrates the significant potential for photogenerated silicon plasma switching of high-performance bulk micromachined mm-wave waveguides.
Highly suppressive CD39+ Tregs decrease during disease activity in patients with Systemic Lupus Erythematosus (P4124) (2013)

Abstract Objective: Reports on changes in the number and function of Tregs in Systemic Lupus Erythematosus (SLE) have been contradictory, possibly because most of those studies focused on identifying the whole Treg population, without dissecting the Treg subsets. This study aimed to enumerate the number and to study the role of various Treg subsets such as CD39+ Tregs, Naïve Tregs and activated Tregs in SLE patients. Results: Thirty SLE patients, 8 with active disease and 22 in remission, were recruited. The proportion of Tregs (CD4+CD25+Foxp3+) did not differ between patients with active lupus and those in remission (8.2±2.4% vs 7.5±3.8%, respectively; p=0.83). Similarly, there were no differences in these two groups of SLE patients in respect to the numbers of the naïve (CD4+CD45RA+Foxp3+) and activated Tregs (CD4+CD45RA-Foxp3high). However, the proportion of CD39+ Tregs was found to be significantly lower SLE patients with a flare, compared to those on remission (21.6±8.1% vs 41.9±4.7%, respectively; p=0.01). FACS-sorted CD39+ Tregs were found to be significantly more suppressive than CD39- Tregs. At the cut-off point 15.3%, CD39+ Tregs differentiated patients with active lupus from those in remission with the sensitivity of 95% and specificity of 75%. Conclusions: Fewer CD39+ Tregs in patients with active lupus indicates that CD39+ Tregs may play a crucial role in the pathogenesis of SLE. Furthermore, peripheral blood CD39+ Treg may be a biomarker for flares in SLE patients.
Channel-limited high-speed links: modeling, analysis and design (2005)

Today's high-speed interfaces are limited by the bandwidth of the communication channel, tight power constraints and noise sources that differ from those in standard communication systems. The bandlimited channels make straight circuit solutions inefficient, and the power constraints make standard digital communication approaches infeasible. This thesis presents a system-level link design approach, integrating the noise and channel properties with communication algorithms and circuit-level power and speed constraints. 
Our model incorporates accurate statistics of the dominant link noise sources. Mapping the timing noise into effective voltage noise reveals the critical impact of high-frequency transmit jitter. The capacity of typical high-speed link backplane channels is shown to be between 50 and 100 Gb/s, which is much higher than 3 Gb/s data rates of currently deployed baseband links. 
To improve these practical links, we solve the power-constrained optimal linear precoding problem and formulate a bit-error rate (BER) driven optimization, including all link-specific noise sources and hardware constraints. We show that practical data rates are mainly limited by inter-symbol interference due to complexity constraints on the number of equalizer taps. The slicer resolution and sampling jitter limit the higher bandwidth utilization provided by multi-level modulations. Better circuits could improve this utilization to more than 2 bits/dimension. With current circuit precision, links with both PAM2 and PAM4 modulation, and a combination of transmit pre-emphasis and decision-feedback equalization (DFE) achieve 5–12 Gb/s data rates. 
With only minor modifications, the hardware needed to implement a PAM4 system can be used in a loop-unrolled single-tap DFE receiver. To get the maximum performance from either technique in practice, the link has to adapt itself to the channel. We designed a low-cost adaptive equalizer using data-based update filtering, which minimizes the required sampler front-end hardware and reduces the implementation cost in multi-level signaling schemes. A transceiver chip was fabricated in a 0.13 μm CMOS process to investigate dual-mode PAM2/PAM4 operation and the modifications of the standard adaptive algorithms necessary to operate in high-speed link environments. The experimental data match the statistical link model predictions extremely well, within a couple of mV, even at BERs lower than the required 10−15.
Smad7 alters cell fate decisions of human hematopoietic repopulating cells (2004)

Intracellular Smad proteins mediate signal transduction of the transforming growth factor-beta (TGF-beta) superfamily that play pleiotropic roles in hematopoietic development, suggesting that intracellular Smad proteins may play key roles in hematopoietic regulation. Although inhibitory Smad7, which negatively regulates TGF-beta signaling, has been implicated in the development of mature hematopoietic cells, a role for Smad7 in regulating more primitive hematopoietic cells has yet to be examined. Here, Smad7 was overexpressed in primary human severe combined immunodeficient (SCID) repopulating cells (SRCs), representing a common myeloid/lymphoid precursor cell with the functional capacity to repopulate the bone marrow of nonobese diabetic (NOD)/SCID recipient mice. Retroviral transduction of Smad7 into human umbilical cord blood (CB)-SRCs caused a shift from lymphoid dominant engraftment toward increased myeloid contribution, and increased the myeloid-committed clonogenic progenitor frequency in reconstituted mice. Neither myeloid nor B-lymphoid lineage developmental stages were compromised by Smad7 overexpression, suggesting Smad7 regulates cell fate commitment decisions of myeloid/lymphoid precursors by augmenting myeloid differentiation at the expense of lymphoid commitment. In addition, global gene expression analysis using microarray was used to identify potential target genes regulated by Smad7 in primitive hematopoietic cells that may control this process. Our study demonstrates a novel and unexpected role for Smad7 in modulating the cell fate decisions of primary multipotent human repopulating cells and establishes a role for Smad7 in the development of primitive human hematopoietic cells.
Implantable resonant mass sensor for liquid biochemical sensing (2004)

This paper describes an implantable, resonant mass sensor (built on a micromachined probe with a piezoelectric thin film) for liquid mass sensing. The sensor is basically a film-bulk-acoustic resonator (FBAR) with a piezoelectric ZnO film and two Al layers sitting on a silicon nitride (SiN) diaphragm, which forms the tip portion of an implantable silicon probe for recording neuronal activities in a living biological tissue.