gebhart/patrepeval huggingface dataset:
A phase I/II, multicenter, open-label study of REGN5668 (mucin [MUC]16 x CD28 bispecific antibody [bsAb]) with cemiplimab (programmed death [PD]-1 Ab) or REGN4018 (MUC16 x CD3 bsAb) in recurrent ovarian cancer (rOVCA). (2021)

TPS5602 Background: There is a high unmet need in rOVCA treatment, with 14,000 deaths/year in the US and a 30%‒40% 5-year overall survival rate in patients (pts) with advanced disease. REGN5668 and REGN4018 are human IgG4-based bsAbs that bridge ovarian MUC16+ tumor cells to CD28 and CD3, respectively, on T-cells to stimulate cytotoxicity. Cemiplimab is a human monoclonal Ab that blocks PD-1 binding to PD-ligand(L)1 and PD-L2. REGN5668 demonstrated increased preclinical anti-tumor activity with PD-1 inhibition or REGN4018 relative to each monotherapy. A Phase I/II study of REGN4018 alone or with cemiplimab is ongoing. Methods: This first-in-human study (NCT04590326) will assess safety, tolerability, pharmacokinetics, and preliminary anti-tumor activity of REGN5668 with cemiplimab (Module 1) or REGN4018 (Module 2) in pts with rOVCA. Key inclusion criteria include histologically confirmed diagnosis of advanced epithelial ovarian (except carcinosarcoma), fallopian tube, or primary peritoneal cancer; serum CA-125 level ≥2x upper normal limit; ≥1 prior-line of platinum-based therapy; prior treatment with or intolerance to available standard-of-care therapy. Exclusion criteria include recent biologic therapy ( &lt; 5 half-lives or 28 days, whichever is longer, except &lt; 3 half-lives for bevacizumab or other nonimmunomodulatory Abs with half-lives &gt; 7 days); approved conventional therapy (except biologics or immunotherapy) &lt; 3 weeks (wks) or investigational agents &lt; 4 wks prior to first study dose; and anti–PD-L1 therapy &lt; 5 half-lives prior to first study dose. This two-phase study includes dose escalation (a 4+3 design modified from 3+3) and expansion phases. In Module 1, ≤84 pts will receive 3–4 wks of REGN5668 monotherapy lead-in at assigned intravenous (IV) weekly (QW) dose levels, followed by REGN5668 QW combined with cemiplimab IV every 3 wks. In Module 2, ≤106 pts will receive 4–5 wks of REGN4018 QW IV lead-in, followed by REGN4018 full QW dose combined with REGN5668 at initial and full assigned QW doses. In expansion, REGN5668+cemiplimab and REGN5668+REGN4018 combination regimens will each recruit 20 pts in stage 1 and 30 pts in stage 2 using a Simon two-stage design. In escalation, primary endpoints are dose-limiting toxicities, serious and treatment-emergent adverse events (TEAEs), deaths, laboratory abnormalities (Grade ≥3), concentrations of REGN5668 in serum alone and in each combination regimen; key secondary endpoint is objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. In expansion, primary endpoint is ORR by RECIST 1.1 for each combination; key secondary endpoints are TEAEs, serious AEs, deaths. Key exploratory endpoints are correlation between clinical efficacy endpoints and baseline protein expression levels of MUC16 and PD-L1. Clinical trial information: NCT04590326.
A liquid crystal and polymer composite film for liquid crystal lenses (2015)

Liquid crystal (LC) lenses offer novel opportunities for applications of ophthalmic lenses, camera modules, pico projectors, endoscopes, and optical zoom systems owing to electrically tunable lens power. Nevertheless, the tunable lens power and the aperture size of LC lenses are limited by the optical phase resulting from limit birefringence of LC materials. Recently, we developed a liquid crystal and polymer composite film (LCPCF) as a separation layer and an alignment layer for a multi-layered structure of LC lenses in order to enlarge the polarization-independent optical phase modulation. However, the physical properties and mechanical properties of the LCPCF are not clearly investigated. In this paper, we show the mechanical and physical properties of the LCPCF. The anchoring energy of the LCPCF is comparable with the standard rubbing-induced alignment layer. The transmission efficiency is around 97% neglecting the Fresnel reflection. The surface roughness is under 2 nm by using AFM scanning. The bending strength test indicates that the LCPCF can hold the LC material with reasonable deformation. We believe this study provides a deeper insight to the LC lens structure embedded with LCPCF.
Super impact absorbing bio-alloys from inedible plants (2017)

Injection molded bio-alloys from inedible plants showed a “salami-like structure in a co-continuous phase” and had superior impact strength with good stiffness, making bio-alloys feasible for applications.
Asymmetric induction in an enammonium-iminium rearrangement. Mechanistic insight via NMR, deuterium labeling, and reaction rate studies. Application to the stereoselective synthesis of pyrroloisoquinoline antidepressants (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric induction in an enammonium-iminium rearrangement. Mechanistic insight via NMR, deuterium labeling, and reaction rate studies. Application to the stereoselective synthesis of pyrroloisoquinoline antidepressantsKirk L. Sorgi, Cynthia A. Maryanoff, David F. McComsey, David W. Graden, and Bruce E. MaryanoffCite this: J. Am. Chem. Soc. 1990, 112, 9, 3567–3579Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00165a048https://doi.org/10.1021/ja00165a048research-articleACS PublicationsRequest reuse permissionsArticle Views754Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Optimal modeling for complex system design [data compression] (1998)

The article begins with a brief introduction to the theory describing optimal data compression systems and their performance. A brief outline is then given of a representative algorithm that employs these lessons for optimal data compression system design. The implications of rate-distortion theory for practical data compression system design is then described, followed by a description of the tensions between theoretical optimality and system practicality and a discussion of common tools used in current algorithms to resolve these tensions. Next, the generalization of rate-distortion principles to the design of optimal collections of models is presented. The discussion focuses initially on data compression systems, but later widens to describe how rate-distortion theory principles generalize to model design for a wide variety of modeling applications. The article ends with a discussion of the performance benefits to be achieved using the multiple-model design algorithms.
Bioengineered blood vessels (2014)

Cardiovascular disease (CVD) affecting blood vessel function is a leading cause of death around the world. A common treatment option to replace the diseased blood vessels is vascular grafting using the patient's own blood vessels. However, patients with CVD are usually lacking vessels for grafting. Recent advances in tissue engineering are now providing alternatives to autologous vascular grafts in the form of tissue-engineered blood vessels (TEBVs). In this review, we will describe the use of different scaffolding systems, cell sources and conditioning approaches for creating fully functional blood vessels. Additionally, we will present the methods used for assessing TEBV functions and describe preclinical and clinical trials for TEBV. Although the early results were encouraging, current designs of TEBV still fall short as a viable clinical option. Implementing the current knowledge in vascular development can lead to improved fabrication and function of TEBV and hasten clinical translation.
A Study of Evoked Potentials From Ear-EEG (2013)

A method for brain monitoring based on measuring the electroencephalogram (EEG) from electrodes placed in-the-ear (ear-EEG) was recently proposed. The objective of this study is to further characterize the ear-EEG and perform a rigorous comparison against conventional on-scalp EEG. This is achieved for both auditory and visual evoked responses, over steady-state and transient paradigms, and across a population of subjects. The respective steady-state responses are evaluated in terms of signal-to-noise ratio and statistical significance, while the qualitative analysis of the transient responses is performed by considering grand averaged event-related potential (ERP) waveforms. The outcomes of this study demonstrate conclusively that the ear-EEG signals, in terms of the signal-to-noise ratio, are on par with conventional EEG recorded from electrodes placed over the temporal region.
Innovative raster-mirror optical detection system for CCD camera bistatic lidar (2005)

An innovative, ground-based bistatic lidar receiver to measure aerosol scattering in the atmospheric boundary layer has been developed and tested for proof-of-concept. The raster-mirror designs have greater than two orders of magnitude light gathering capability, and higher altitude resolution than the design used in Barnes et. al., thus allowing the use of lower power eye safe lasers. The design is based on dividing the wide 100° vertical field of view into several sectors, using 1-D rastering of mirrors and parallel imaging of the laser light scattered from each sector onto one CCD while employing a single narrow angle-of-view objective. The system is applicable for simultaneous measurements of several laser beams to obtain spectral, spatial, and temporal information about the atmosphere. Using an off-axis parabolic mirror objective eliminates chromatic aberrations, making the system employable in a broad spectral range from IR to UV. The advantages of the proposed technology are: the ability to control the dynamic range of the registered signal, the superior height resolution of 14 mm/pixel at the ground level, and 175m/pixel at 20km altitude, low cost, and simplicity. The bistatic CLidar receiver will include automatic system feedback and self-calibration. The system will be developed to accommodate daytime operational conditions.
<title>Effect of Fe and Cu contamination on the reliability of ultrathin gate oxides</title> (1999)

The detrimental effect of heavy metal contamination on gate oxide reliability has been well documented for oxides thicker than 7 nm. This study offers evidence of the detrimental effect that metallic (Fe, Cu) contamination has on ultra-thin gate oxide reliability. Oxides grown at 850 degrees Celsius of 3.5 and 7 nm thickness were intentionally contaminated with Fe (pre-oxidation) or Cu (pre- and post-oxidation.) Bulk silicon FE concentrations of 5 X 10<SUP>10</SUP> to 1 X 10<SUP>13</SUP> atoms/cm<SUP>3</SUP> were achieved through the spin doping of an aqueous FeCl<SUB>3</SUB> solution on the wafer surface prior to oxidation. Pre-oxidation Cu contamination was attained through full wafer immersion in a 10:1 HF:H<SUB>2</SUB>O solution contaminated with CuSO<SUB>4</SUB> of varying Cu concentrations (1 ppb to 100 ppb), while post-oxidation contamination results from a 30 minute 450 degree Celsius forming gas anneal which drives in Cu previously deposited on the backside of the wafer. A new corona-based technique was used to measure the stress-induced leakage current (SILC) characteristics of the contaminated and control oxides after various stress fluences, from 10<SUP>-5</SUP> to 10<SUP>-1</SUP> C/cm<SUP>2</SUP>, in either the Fowler-Nordheim or the direct tunneling regime for the 7 and 3.5 nm oxides respectively. This non-contact technique employing the COCOS (Corona Oxide Characterization of Semiconductor) methodology measures current flowing through the oxide as a function of the oxide electric field induced by corona. In addition, electrical measurements on MOS capacitors were performed and the results compared to COCOS SILC results. For the 7 nm oxides, COCOS measurements clearly showed enhanced SILC due to metallic contamination confirming previous findings. For the 3.5 nm oxides, two distinct features were established: (1) pre-stress I-V characteristics were consistent with a direct tunneling mechanism exhibiting a distinct shift to higher currents at lower electric fields and (2) the SILC was smaller in magnitude than that exhibited by the 7 nm oxides. Existing SILC models (i.e. trap-assisted tunneling) were used to interpret the I-V data. In addition, this stress resulted in oxide wearout, which produced noticeable flat-band shifts and an order of magnitude increase in interface state density, also measured using the COCOS technique. The effect of metallic contamination on these wearout issues was also investigated.
ChemInform Abstract: Lanthanoids and Actinoids. Annual Survey Covering the Years 1987‐1989 (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On-Chip Hybrid Silicon Quantum Dot Comb Laser with 14 Error-Free Channels (2018)

We present a quantum dot-based hybrid silicon comb laser using wafer bonding. Multimode interferometer-based on-chip mirrors and grating couplers are integrated on the silicon for wafer-level testing. We show error-free operation in 14 channels.
Identification of CT521 as a Frequent Target of Th1 Cells in Patients with UrogenitalChlamydia trachomatisInfection (2006)

We have identified a novel C. trachomatis antigen, CT521, that is frequently recognized in patients with urogenital C. trachomatis infection.
A novel quarter‐wave retardation film for improving viewing angle properties in time‐sequential stereoscopic 3D‐LCDs (2012)

Abstract We have successfully developed a quarter‐wave retardation film (QWF) for wide viewing angle 3D liquid crystal displays (3D‐LCDs) that provides high luminance, low crosstalk, low color change, and low head‐tilt‐angle dependency. It was found that the out‐of‐plane retardation (Rth) of the QWF in the LCD needs to be close to 0 nm in order to improve the 3D display properties at an off‐axis position and that the in‐plane retardation (Re) needs to be adjusted from 120 to 130 nm to achieve low color change with head tilting. We adopted a coating process for making our QWF because of its potential for retardation control. 3D‐LCDs with this QWF whose Rth was nearly zero had high performance and allowed off‐axis other than on‐axis.
Method and apparatus for virtualizing the micro-op cache (2023)

Systems, apparatuses, and methods for virtualizing a micro-operation cache are disclosed. A processor includes at least a micro-operation cache, a conventional cache subsystem, a decode unit, and control logic. The decode unit decodes instructions into micro-operations which are then stored in the micro-operation cache. The micro-operation cache has limited capacity for storing micro-operations. When new micro-operations are decoded from pending instructions, existing micro-operations are evicted from the micro-operation cache to make room for the new micro-operations. Rather than being discarded, micro-operations evicted from the micro-operation cache are stored in the conventional cache subsystem. This prevents the original instruction from having to be decoded again on subsequent executions. When the control logic determines that micro-operations for one or more fetched instructions are stored in either the micro-operation cache or the conventional cache subsystem, the control logic causes the decode unit to transition to a reduced-power state.
Studies Addressing the Importance of Charge in the Binding of Fosmidomycin‐Like Molecules to Deoxyxylulosephosphate Reductoisomerase (2008)

Fosmidomycin and its homologue FR900098 are inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, which is part of the mevalonate-independent isoprenoid biosynthetic pathway. Replacement of the phosphonate moiety by uncharged sulfone or sulfonamide partial structures resulted in complete loss of activity. Dropping one of the two negative charges resulted in a marked decrease in activity. Through occupation of a hydrophobic binding site, some activity could be regained, leading to compounds with micromolar activity against cultured malaria parasites.
Receding meniscus induced docking of yeast cells inside microfluidic channels at single cell level (2006)

We present a simple receding meniscus induced method to capture non-adherent yeast cells onto microwells inside microfluidic channels. Microwells were fabricated by capillary molding onto glass substrate using a UV curable polyurethane acrylate (PUA) solution, leading to well-defined, robust microstructures. A cell suspension of the budding yeast, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Saccharomyces cerevisiae</i> , was introduced into microfluidic channels by capillary filling and a receding meniscus was subsequently generated by evaporation. As the meniscus receded, one to five yeast cells were spontaneously captured onto microwells by lateral capillary force created at the thin region of the meniscus. Using this cell-based platform, we observed the response of yeast cells upon stimulation by a mating pheromone (α-factor) by monitoring the expression of green fluorescent protein (GFP) with time. It was observed that α-factor triggered the expression of GFP at 60 min after stimulation and the fluorescence intensity was sustained for additional 60 min without changes
Correction: Corrigendum: Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway (2016)

Nature Communications 6: Article number: 10005 (2015); Published: 24 November 2015; Updated: 7 June 2016 In the original version of this Article the chemical structures of 2-ketoisovaleric acid and isobutanal in Fig. 3a were incorrect. The correct version of Fig. 3 appears below. Figure 3
Immune Dysregulation in Myelodysplastic Syndrome (2010)

Myelodysplastic syndrome (MDS) represents one of the most challenging health-related problems in the elderly. Characterized by dysplastic morphology in the bone marrow in association with ineffective hematopoiesis, pathophysiological causes of this disease are diverse including genetic abnormalities within myeloid progenitors, altered epigenetics, and changes in the bone marrow microenvironment. The concept that T-cell mediated autoimmunity contributes to bone marrow failure has been widely accepted due to hematologic improvement after immunosuppressive therapy (IST) in a subset of patients. Currently, IST for MDS primarily involves anti-thymocyte globulin (ATG)-based regimens in which responsiveness is strongly associated with younger (under 60 years) age at disease onset. In such cases, progressive cytopenia may occur as a consequence of expanded self-reactive CD8(+) cytotoxic T lymphocytes (CTLs) that suppress hematopoietic progenitors. Although most hematologists agree that IST can offer durable hematologic remission in younger patients with MDS, an international clinical study and a better understanding of the molecular mechanisms contributing to the expansion of self-reactive CTLs is crucial. In this review, data accumulated in the US, Europe, and Asia will be summarized to provide insight and direction for a multi-center international trial.
Conformational studies by nuclear magnetic resonance—III: ASIS and protonation studies of the rotational isomerism of enamino aldehydes and ketones (1972)

Abstract The s ‐ cis ⇌ s ‐ trans equilibrium of several enamino ketones and aldehydes, equation image has been evaluated based on the results of aromatic solvent induced shift measurements and of protonation of the title compounds. In contrast to α,β‐unsaturated ketones bearing no heteroatom, the Δδ 3, cis value but not the Δδ 3, trans , proved to be useful in conformational assignments. Protonation, which occurs mainly on oxygen, enhances the rotational barrier, thus enabling the observation of both rotamers at room temperature. Steric hindrance to conjugation enhances the rate of protonation at the carbon C 2 .
Evaluating task performance for a unidirectional controlled language medical speech translation system (2006)

We present a task-level evaluation of the French to English version of MedSLT, a medium-vocabulary unidirectional controlled language medical speech translation system designed for doctor-patient diagnosis interviews. Our main goal was to establish task performance levels of novice users and compare them to expert users. Tests were carried out on eight medical students with no previous exposure to the system, with each student using the system for a total of three sessions. By the end of the third session, all the students were able to use the system confidently, with an average task completion time of about 4 minutes.
Nut allergy prevalence and differences between Asian‐born children and Australian‐born children of Asian descent: a state‐wide survey of children at primary school entry in Victoria, Australia (2016)

Migration from Asia after the early infant period appears protective for the development of nut allergy. Additionally, rural regions have lower rates of nut allergy than urban areas.
Propranolol induces hyperreactivity in lung parenchyma strips from sensitized guinea pigs (1989)

Abstract Propranolol causes airway hyperreactivity to agonists or antigenic challenge in vivo, but its mechanisms are still debated. In this study we found that the addition of propranolol (10 μ/ml) to lung parenchyma strips from sensitized guinea pigs enhanced the sensitivity and maximum contraction to antigenic challenge (ovalbumin, 0.01–100 μ/ml) and the sensitivity to histamine (1 × 10 −7 to 1.7 × 10 −4 M), determined through concentration‐response curves. In contrast, tracheal chains from sensitized guinea pigs were unaffected. These results in in vitro preparations strongly suggest that, at least in lung parenchyma tissue, other mechanisms different from beta‐blockade are present in propranolol‐induced airway hyperreactivity.
Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome (2014)

CXCR4(+) fibrocyte concentration may be useful as a biomarker for outcome of ILD in subjects with HPS.