gebhart/patrepeval huggingface dataset:
Understanding the Degradation Pathway of the Pesticide, Chlorpyrifos by Noble Metal Nanoparticles (2012)

Application of nanoparticles (NPs) in environmental remediation such as water purification requires a detailed understanding of the mechanistic aspects of the interaction between the species involved. Here, an attempt was made to understand the chemistry of noble metal nanoparticle-pesticide interaction, as these nanosystems are being used extensively for water purification. Our model pesticide, chlorpyrifos (CP), belonging to the organophosphorothioate group, is shown to decompose to 3,5,6-trichloro-2-pyridinol (TCP) and diethyl thiophosphate at room temperature over Ag and Au NPs, in supported and unsupported forms. The degradation products were characterized by absorption spectroscopy and electrospray ionization mass spectrometry (ESI MS). These were further confirmed by ESI tandem mass spectrometry. The interaction of CP with NP surfaces was investigated using transmission electron microscopy, energy dispersive analysis of X-rays, Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). XPS reveals no change in the oxidation state of silver after the degradation of CP. It is proposed that the degradation of CP proceeds through the formation of AgNP-S surface complex, which is confirmed by Raman spectroscopy. In this complex, the P-O bond cleaves to yield a stable aromatic species, TCP. The rate of degradation of CP increases with increase of temperature and pH. Complete degradation of 10 mL of 2 ppm CP solution is achieved in 3 h using 100 mg of supported Ag@citrate NPs on neutral alumina at room temperature at a loading of ∼0.5 wt %. The effect of alumina and monolayer protection of NPs on the degradation of CP is also investigated. The rate of degradation of CP by Ag NPs is greater than that of Au NPs. The results have implications to the application of noble metal NPs for drinking water purification, as pesticide contamination is prevalent in many parts of the world. Study shows that supported Ag and Au NPs may be employed in sustainable environmental remediation, as they can be used at room temperature in aqueous solutions without the use of additional stimulus such as UV light.
HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis (2018)

Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial against idiopathic pulmonary fibrosis. Here we show that OGX-427 is effective in two murine models of thrombopoietin- and JAKV617F-induced myelofibrosis. OGX-427 limits disease progression and is associated with a reduction in spleen weight, in megakaryocyte expansion and, for the JAKV617F model, in fibrosis. HSP27 regulates the proliferation of JAK2V617F-positive cells and interacts directly with JAK2/STAT5. We also show that its expression is increased in both CD34<sup>+</sup> circulating progenitors and in the serum of patients with JAK2-dependent myeloproliferative neoplasms with fibrosis. Our data suggest that HSP27 plays a key role in the pathophysiology of myelofibrosis and represents a new potential therapeutic target for patients with myeloproliferative neoplasms.
Characteristics of rib waveguide racetrack resonators in SOI (2006)

Optical ring/racetrack resonators have the sufficient flexibility to realise many functions in a single device, from filters/multiplexers, to modulators, to switches. The use of Silicon-On-Insulator (SOI) material, coupled with Ultra Large Scale Integration (ULSI) processing techniques, may allow the cost of these devices to become economically advantageous over current components. This paper describes our recent work in developing polarisation independent ring resonators, and subsequent, work on increasing the limited free spectral range and full width half maximum of the resonance. There are two key components that comprise a polarisation-independent racetrack resonator: a polarisation-independent rib waveguide and a polarisation-independent directional coupler. Polarisation independence is achieved in the waveguides when the geometrical design ensures that both polarisation modes propagate with the same effective index. We report on such devices together with polarisation independent couplers, which are achieved by allowing different inter multiples of the coupling length for the TE and the TM modes. By combining these components, the resulting device is a polarisation independent ring resonators. These devices have been thermally modulated by means of a modulated visible laser and alternatively via small heaters fabricated on the waveguides. We have also modelled ring resonator modulators via carrier injection and depletion. Subsequently we have improved the device characteristics by employing smaller bend radii to increase the free spectral range by a factor of 5, and by cascading racetracks to improve the full width half maxima of the resonance by almost 40%. Experimental results are reported for most of the above characteristics. We will further investigate the opportunities for increasing the FSR whilst retaining polarisation independence, the possibility of retaining polarisation independence whilst utilising the properties of the ring resonator to form improved modulators.
Polio, including the postpolio syndrome (1992)

Log in or Register Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Register Login HomeCurrent IssuePrevious Issues Current Orthopaedic PracticeCurrent Opinion in Orthopaedics (1999-2007)Clinical Orthopaedics and Related Research (1976-2007) Published Ahead-of-PrintCOP eNewsMy CollectionsJournal Info About the JournalEditorial BoardInformation for AuthorsAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Differential top-antitop cross-section measurements as a function of observables constructed from final-state particles using pp collisions at s = 7 $$ \sqrt{s}=7 $$ TeV in the ATLAS detector (2015)

Various differential cross-sections are measured in top-quark pair (t t) events produced in proton-proton collisions at a centre-of-mass energy of s = 7 TeV at the LHC with the ATLAS detector. These differential cross-sections are presented in a data set corresponding to an integrated luminosity of 4.6 fb -1 . The differential cross-sections are presented in terms of kinematic variables, such as momentum, rapidity and invariant mass, of a top-quark proxy referred to as the pseudo-top-quark as well as the pseudo-top-quark pair system. The dependence of the measurement on theoretical models is minimal.
The Right to Public Health (2021)

Abstract This chapter reframes the project of public health within a rights framework. It argues that there is a right to health, and this entails that individuals have a right to public health. Given that there is a right to public health, the state should undertake to reduce health risks. If a state does not take easy steps to reduce risks to health, and as a result allows significant numbers to come to harm or even death, then it violates individuals’ right to public health, and should be criticized as a Neglectful State. The ethical challenge of public health policy is therefore not the one-sided one of avoiding Nannying, but the more complex task of steering a course between Nannying and Neglect. Avoiding Neglect may involve restricting liberty in various ways.
MP46-10 INITIAL SCREENING USING PCA3 WITH PSAD IMPROVED PROSTATE CANCER DETECTION (2018)

previous negative biopsy, and continued suspicion of prostate cancer, we are seeing an increased utilization on mpMRI in biopsy naive men. We performed a systematic review and meta-analysis of prospective studies looking at the performance of mpMRI on prostate cancer detection in men who had never undergone a previous biopsy of the prostate.
Modulation of Flat-band Potential and Increase in Photovoltage for n-Si Electrodes by Formation of Halogen Atom Terminated Surface Bonds (1997)

Abstract The flat-band potential (UFB) of n-Si electrodes in concentrated hydrogen halide (HX) solutions, as determined from Mott-Schottky plots and the onset potential of photocurrent, shifts largely toward the negative with the decreasing electronegativity of halogen atoms. XPS studies have shown the presence of halogen atoms on the Si electrodes which were beforehand immersed in the HX solutions. The shift in UFB can be explained as due to changes in surface potential by formation of Si-halogen surface termination bonds.
Introduction : Le gouvernement de la métropole parisienne. Problème d'État et opposition Paris/banlieue (2020)

Cette publication n'a pas de résumé
Changes in functioning of mesolimbic incentive processing circuits during the premenstrual phase (2010)

The premenstrual phase of the menstrual cycle is associated with marked changes in normal and abnormal motivated behaviors. Animal studies suggest that such effects may result from actions of gonadal hormones on the mesolimbic dopamine (DA) system. We therefore investigated premenstrual changes in reward-related neural activity in terminal regions of the DA system in humans. Twenty-eight healthy young women underwent functional magnetic resonance imaging on 2 days during the menstrual cycle, once during the late follicular phase and once during the premenstrual phase, in counterbalanced order. Using a modified version of the monetary incentive delay task, we assessed responsiveness of the ventral striatum to reward anticipation. Our results show enhanced ventral striatal responses during the premenstrual as compared to the follicular phase. Moreover, this effect was most pronounced in women reporting more premenstrual symptoms. These findings provide support for the notion that changes in functioning of mesolimbic incentive processing circuits may underlie premenstrual changes in motivated behaviors. Notably, increases in reward-cue responsiveness have previously been associated with DA withdrawal states. Our findings therefore suggest that the sharp decline of gonadal hormone levels in the premenstrual phase may trigger a similar withdrawal-like state.
Structural Basis for the Modulation of Lignin Monomer Methylation by Caffeic Acid/5-Hydroxyferulic Acid 3/5-O-Methyltransferase (2002)

Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase (COMT) from alfalfa is an S-adenosyl-L-Met-dependent O-methyltransferase involved in lignin biosynthesis. COMT methylates caffeoyl- and 5-hydroxyferuloyl-containing acids, aldehydes, and alcohols in vitro while displaying a kinetic preference for the alcohols and aldehydes over the free acids. The 2.2-A crystal structure of COMT in complex with S-adenosyl-L-homocysteine (SAH) and ferulic acid (ferulate form), as well as the 2.4-A crystal structure of COMT in complex with SAH and 5-hydroxyconiferaldehyde, provide a structural understanding of the observed substrate preferences. These crystal structures identify residues lining the active site surface that contact the substrates. Structurally guided site-directed mutagenesis of active site residues was performed with the goal of altering the kinetic preferences for physiological substrates. The kinetic parameters of the COMT mutants versus wild-type enzyme are presented, and coupled with the high-resolution crystal structures, they will serve as a starting point for the in vivo manipulation of lignin monomers in transgenic plants. Ultimately, this structurally based approach to metabolic engineering will allow the further alteration of the lignin biosynthetic pathway in agronomically important plants. This approach will lead to a better understanding of the in vivo operation of the potential metabolic grid for monolignol biosynthesis.
Supplementary Figure S4 from Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Supplementary Figure S4 - PDF file 1158K, Efficacy of EL4-based iLOV&lt;/p&gt;
Extraction of Message Sequence Charts from Software Use-Case Descriptions (2019)

Girish Palshikar, Nitin Ramrakhiyani, Sangameshwar Patil, Sachin Pawar, Swapnil Hingmire, Vasudeva Varma, Pushpak Bhattacharyya. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 2 (Industry Papers). 2019.
Improving the Quality of Delay-Based PUFs via Optical Proximity Correction (2013)

Silicon physically unclonable functions (PUFs) are circuits that exploit modern manufacturing variations to generate unique signatures for chip authentication and cryptographic key generation. Existing research has focused on improving PUF quality at architectural or design levels, but has ignored opportunities available during fabrication, which is the source of systematic and random variation in (ICs)/PUFs. For typical ICs (where security is not a concern), optical proximity correction (OPC) is used to suppress both these types of variations. However, several prior works have shown that only systematic variations negatively impact PUF quality and random variations are beneficial for PUFs. In this paper, we propose two PUF-aware OPC cost functions: 1) P-OPC generates a PUF lithography mask that increases all variations in PUF circuitry (the opposite of state-of-the-art OPC), and 2) SVC-OPC generates mask patterns that reduce the systematic variation found in PUFs for better quality. Simulation results for ring oscillator (RO) PUFs show that the proposed techniques can improve PUF signature quality compared to current state-of-the-art OPC.
Commentary: Neurosurgery and the Ongoing American Opioid Crisis (2017)

Mount Sinai Hospital, New York, New York Correspondence: Brian Harris Kopell, MD, Mount Sinai Hospital, 1 Gustav Levy Pl, Annenberg Building, 8th floor, New York, NY 10029. E-mail: [email protected]
Representing and reasoning about commitments in business processes (2007)

A variety of business relationships in open settings can be understood in terms of the creation and manipulation of commitments among the participants. These include B2C and B2B contracts and processes, as realized via Web services and other such technologies. Business protocols, an interaction-oriented approach for modeling business processes, are formulated in terms of the commitments. Commitments can support other forms of semantic service composition as well. This paper shows how to represent and reason about commitments in a general manner. Unlike previous formalizations, the proposed formalization accommodates complex and nested commitment conditions, and concurrent commitment operations. In this manner, a rich variety of open business scenarios are enabled.
Ultraviolet photoelectron spectra of mass-selected copper clusters: Evolution of the 3dband (1990)

Ultraviolet photoelectron spectra (UPS) have been measured for bare unsupported copper clusters in the 1--410 atom size range as mass selected from a supersonic, negatively charged, cluster ion beam. Using an ${\mathrm{F}}_{2}$ excimer laser at 7.9 eV, the UPS patterns display the evolution of the 3d band structure as a function of cluster size. Clusters larger than a few atoms were found to display an increasingly sharp feature at the onset of the 3d band similar to that seen for bulk copper UPS at low photon energies, suggesting that these larger clusters may already be crystalline.
Learning a Generic Value-Selection Heuristic Inside a Constraint Programming Solver (2017)

Constraint programming is known for being an efficient approach to solving combinatorial problems. Important design choices in a solver are the branching heuristics, designed to lead the search to the best solutions in a minimum amount of time. However, developing these heuristics is a time-consuming process that requires problem-specific expertise. This observation has motivated many efforts to use machine learning to automatically learn efficient heuristics without expert intervention. Although several generic variable-selection heuristics are available in the literature, the options for value-selection heuristics are more scarce. We propose to tackle this issue by introducing a generic learning procedure that can be used to obtain a value-selection heuristic inside a constraint programming solver. This has been achieved thanks to the combination of a deep Q-learning algorithm, a tailored reward signal, and a heterogeneous graph neural network. Experiments on graph coloring, maximum independent set, and maximum cut problems show that this framework competes with the well-known impact-based and activity-based search heuristics and can find solutions close to optimality without requiring a large number of backtracks.
FMMU: A Hardware-Automated Flash Map Management Unit for Scalable Performance of NAND Flash-Based SSDs (2017)

NAND flash-based Solid State Drives (SSDs), which are widely used from embedded systems to enterprise servers, are enhancing performance by exploiting the parallelism of NAND flash memories. To cope with the performance improvement of SSDs, storage systems have rapidly adopted the host interface for SSDs from Serial-ATA, which is used for existing hard disk drives, to high-speed PCI express. Since NAND flash memory does not allow in-place updates, it requires special software called Flash Translation Layer (FTL), and SSDs are equipped with embedded processors to run FTL. Existing SSDs increase the clock frequency of embedded processors or increase the number of embedded processors in order to prevent FTL from acting as bottleneck of SSD performance, but these approaches are not scalable. This paper proposes a hardware-automated Flash Map Management Unit, called FMMU, that handles the address translation process dominating the execution time of the FTL by hardware automation. FMMU provides methods for exploiting the parallelism of flash memory by processing outstanding requests in a non-blocking manner while reducing the number of flash operations. The experimental results show that the FMMU reduces the FTL execution time in the map cache hit case and the miss case by 44% and 37%, respectively, compared with the existing software-based approach operating in 4-core. FMMU also prevents FTL from acting as a performance bottleneck for up to 32-channel, 8-way SSD using PCIe 3.0 x32 host interface.
Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans (2018)

Abstract Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in intra-organismal signaling, whereas biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in C. elegans , a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron ASH is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in sensing osas#9. The TYRA-2/osas#9 signaling system thus represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor.
Thermal Conductive Properties of a Semiconductor Laser on a Polymer Interposer (2013)

We have calculated the thermal conductive properties and rate of temperature increase of a semiconductor laser on a polymer substrate. The temperature rises to 27 °C on the polymer interposer and the heat radiation effect is almost saturated in the case where the Au film has a thickness of 500 nm at 10 mW. Also, we have fabricated a 1.3 µm quantum dot (QD) laser with a stripe structure for the polymer interposer. We can achieve a low operating current threshold of 7 mA for the QD laser with a high mirror loss of 16 cm -1 at 1.3 µm emission because of the high quality of the QDs and the low scattering loss structure. Moreover, we have measured the heat distribution and rising temperature speed of a QD laser on a polymer substrate. These results indicate that we need to realize a high-efficiency laser source to achieve high transmission speeds in the future.
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis (2018)

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and phosphatases. A handful of major mitotic protein kinases, such as the cyclin B-CDK1 complex, the Aurora kinases, and Polo-like kinase 1 (PLK1), cooperatively regulate distinct mitotic processes. Research has identified proteins and mechanisms that integrate these kinases into signaling cascades that guide essential mitotic events. These findings have important implications for our understanding of the mechanisms of mitotic regulation and may advance the development of novel antimitotic drugs. We review collected evidence that in vertebrates, the Aurora kinases serve as catalytic subunits of distinct complexes formed with the four scaffold proteins Bora, CEP192, INCENP, and TPX2, which we deem "core" Aurora cofactors. These complexes and the Aurora-PLK1 cascades organized by Bora, CEP192, and INCENP control crucial aspects of mitosis and all pathways of spindle assembly. We compare the mechanisms of Aurora activation in relation to the different spindle assembly pathways and draw a functional analogy between the CEP192 complex and the chromosomal passenger complex that may reflect the coevolution of centrosomes, kinetochores, and the actomyosin cleavage apparatus. We also analyze the roles and mechanisms of Aurora-PLK1 signaling in the cell and centrosome cycles and in the DNA damage response.
Disparate subcellular location of putative sortase substrates in Clostridium difficile (2017)

Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3392 are functional substrates of sortase SrtB. Through manipulation of the C-terminal regions of these proteins we show the SPKTG motif is essential for covalent attachment to the cell wall. Two additional putative substrates, CD0183 which contains an SPSTG motif, and CD2768 which contains an SPQTG motif, are not cleaved or anchored to the cell wall by sortase. Finally, using an in vivo asymmetric cleavage assay, we show that despite containing a conserved SPKTG motif, in the absence of SrtB these proteins are localised to disparate cellular compartments.