gebhart/patrepeval huggingface dataset:
Ligand substitution reactions in metal cluster complexes. Evidence for unusually facile metal-metal bond cleavages in the reactions of osmium clusters Os3(CO)11(NCMe) and Os3(CO)10(NCMe)2 with CNCF3 including the isolation and structural characterization of intermediates (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand substitution reactions in metal cluster complexes. Evidence for unusually facile metal-metal bond cleavages in the reactions of osmium clusters Os3(CO)11(NCMe) and Os3(CO)10(NCMe)2 with CNCF3 including the isolation and structural characterization of intermediatesRichard D. Adams, Yun Chi, Darryl D. DesMarteau, Dieter Lentz, Robert Marschall, and Andreas ScherrmannCite this: J. Am. Chem. Soc. 1992, 114, 27, 10822–10826Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00053a018https://doi.org/10.1021/ja00053a018research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Three-Dimensional TEM Tomography Analysis of Epitaxially Assembled Perovskite Oxide Nanocrystalline Particles (2008)

We investigated epitaxial assembly in aggregates of CaTiO3 nanoparticles, which were synthesized under a hydrothermal condition at 150°C using water/ethanol solvent, by transmission electron microscopy analysis combined with a three-dimensional tomography technique. The obtained results indicate that epitaxial assembly is involved in the crystal growth of CaTiO3 nanoparticles, and that in aggregates of CaTiO3 nanoparticles epitaxial assembly occur on their {101} planes.
A Rapid, Accurate Determination of Glyceryl Trinitrate and Chloroglyceryl Dinitrate in Pharmaceutical Preparation (1965)

Journal Article A Rapid, Accurate Determination of Glyceryl Trinitrate and Chloroglyceryl Dinitrate in Pharmaceutical Preparation Get access Eric T. Fossel Eric T. Fossel Unimed, Incorporated, Morristown, New Jersey Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 3, Issue 5, May 1965, Page 179, https://doi.org/10.1093/chromsci/3.5.179 Published: 01 May 1965
ChemInform Abstract: Synthesis of Two Bis‐m‐quinomethanes. An Experimental Study of Connectivity Effects on the Equal‐Parity Criterion for Low‐Spin Ground States in Alternant Non‐Kekule′ Molecules. (1986)

Abstract Benzylic bromination of (I) followed by hydrolysis of the resulting mixture of bromo ketones to hydroxy ketones and oxidation with PCC gives a separable mixture of the s‐hydrindacenediones (II) and (III).
Optical dynamic gain equalizer using parallel motion type of ELCIA (2003)

This paper proposes an optical dynamic gain equalizer (DGEQ) using parallel motion type of ECLIA (Electrostatic Controlled Linear Inchworm Actuator). A slider of ECLIA attenuates an intensity of an optical beam, so that parallel motions of arrayed sliders can control and equalize a spectrum of demultiplexed signals from a grating. A designed optical DGEQ takes the following advantages of ECLIA to provide gain flattening of spectral gain non-uniformities: Precise motion, Large stroke, Parallel motions of arrayed sliders. Through our experiments, ECLIA could attenuate about 20 dB in optical intensity when its slider traveled approximately 380 /spl mu/m. This paper presents a system design, system performances, and our current research progress toward integrated system.
Transposon Tagging of the Defective embryo and meristems Gene of Tomato (1998)

James S. Keddie, Bernard J. Carroll, Colwyn M. Thomas, Melquiades E. C. Reyes, Victor Klimyuk, Hans Holtan, Wilhelm Gruissem, Jonathan D. G. Jones, Transposon Tagging of the Defective embryo and meristems Gene of Tomato, The Plant Cell, Vol. 10, No. 6 (Jun., 1998), pp. 877-887
ChemInform Abstract: Structure of the Products from the Addition Reaction of Thiosemicarbazides and Thiosemicarbazones with Acetylenedicarboxyclic Acid and Its Dimethyl Ester. (1990)

Abstract Thiosemicarbazides and thiosemicarbazones react with acetylenedicarboxylic acid (IIa) or its dimethylester (IIb) to give thiazolidines as outlined in the scheme.
Identifying Computer-Generated Portraits: The Importance of Training and Incentives (2017)

The past two decades have seen remarkable advances in photo-realistic rendering of everything from inanimate objects to landscapes, animals, and humans. We previously showed that despite these tremendous advances, human observers remain fairly good at distinguishing computer-generated from photographic images. Building on these results, we describe a series of follow-up experiments that reveal how to improve observer performance. Of general interest to anyone performing psychophysical studies on Mechanical Turk or similar platforms, we find that observer performance can be significantly improved with the proper incentives.
ICON: Implicit Clothed humans Obtained from Normals (2022)

Current methods for learning realistic and animatable 3D clothed avatars need either posed 3D scans or 2D images with carefully controlled user poses. In contrast, our goal is to learn an avatar from only 2D images of people in unconstrained poses. Given a set of images, our method estimates a detailed 3D surface from each image and then combines these into an animatable avatar. Implicit functions are well suited to the first task, as they can capture details like hair and clothes. Current methods, however, are not robust to varied human poses and often produce 3D surfaces with broken or disembodied limbs, missing details, or non-human shapes. The problem is that these methods use global feature encoders that are sensitive to global pose. To address this, we propose ICON (“Tmplicit Clothed humans Obtained from Normals”), which, instead, uses local features. ICON has two main modules, both of which exploit the SMPL(-X) body model. First, ICON infers detailed clothed-human normals (front/back) conditioned on the SMPL(-X) normals. Second, a visibility-aware implicit surface regressor produces an iso-surface of a human occupancy field. Importantly, at inference time, a feedback loop alternates between refining the SMPL(-X) mesh using the inferred clothed normals and then refining the normals. Given multiple reconstructed frames of a subject in varied poses, we use a modified version of SCANimate to produce an animatable avatar from them. Evaluation on the AGORA and CAPE datasets shows that ICON outperforms the state of the art in reconstruction, even with heavily limited training data. Additionally, it is much more robust to out-of-distribution samples, e.g., in-the-wild poses/images and out-of-frame cropping. ICON takes a step towards robust 3D clothed human reconstruction from in-the-wild images. This enables avatar creation directly from video with personalized pose-dependent cloth deformation. Models and code are available for research at https://icon.is.tue.mpg.de.
A 3.5-mW, 2.5-GHz diversity receiver and a 1.2-mW, 3.6-GHz VCO in silicon on anything (1998)

In this paper, first results of radio-frequency (RF) circuits processed in a novel silicon bipolar technology called silicon on anything (SOA) are presented. This technology was developed with the application of low-power, high-frequency circuits in mind. Three test ICs are discussed: a fully integrated 3.6-GHz voltage-controlled oscillator, a fully integrated 2.5-GHz diversity receiver front end, and an intermediate-frequency IC containing channel selectivity and demodulation circuits. Measurement results show that using this technology, significant power savings are possible for RF circuits.
Supplementary Methods from Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment (2023)

&lt;p&gt;PDF file - 38KB, Protocol for Avatar Generation.&lt;/p&gt;
Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019)

Metabotropic glutamate (mGlu) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Metabotropic Glutamate Receptors [334]) are a family of G protein-coupled receptors activated by the neurotransmitter glutamate. The mGlu family is composed of eight members (named mGlu1 to mGlu8) which are divided in three groups based on similarities of agonist pharmacology, primary sequence and G protein coupling to effector: Group-I (mGlu1 and mGlu5), Group-II (mGlu2 and mGlu3) and Group-III (mGlu4, mGlu6, mGlu7 and mGlu8) (see Further reading).Structurally, mGlu are composed of three juxtaposed domains: a core G protein-activating seven-transmembrane domain (TM), common to all GPCRs, is linked via a rigid cysteine-rich domain (CRD) to the Venus Flytrap domain (VFTD), a large bi-lobed extracellular domain where glutamate binds. The structures of the VFTD of mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 have been solved [190, 262, 255, 386]. The structure of the 7 transmembrane (TM) domains of both mGlu1 and mGlu5 have been solved, and confirm a general helical organization similar to that of other GPCRs, although the helices appear more compacted [85, 415, 59]. mGlu form constitutive dimers crosslinked by a disulfide bridge. Recent studies revealed the possible formation of heterodimers between either group-I receptors, or within and between group-II and -III receptors [86]. Although well characterized in transfected cells, co-localization and specific pharmacological properties also suggest the existence of such heterodimers in the brain [422, 257]. The endogenous ligands of mGlu are L-glutamic acid, L-serine-O-phosphate, N-acetylaspartylglutamate (NAAG) and L-cysteine sulphinic acid. Group-I mGlu receptors may be activated by 3,5-DHPG and (S)-3HPG [29] and antagonized by (S)-hexylhomoibotenic acid [223]. Group-II mGlu receptors may be activated by LY389795 [256], LY379268 [256], eglumegad [337, 416], DCG-IV and (2R,3R)-APDC [338], and antagonised by eGlu [161] and LY307452 [408, 100]. Group-III mGlu receptors may be activated by L-AP4 and (R,S)-4-PPG [125]. An example of an antagonist selective for mGlu receptors is LY341495, which blocks mGlu2 and mGlu3 at low nanomolar concentrations, mGlu8 at high nanomolar concentrations, and mGlu4, mGlu5, and mGlu7 in the micromolar range [176]. In addition to orthosteric ligands that directly interact with the glutamate recognition site, allosteric modulators that bind within the TM domain have been described. Negative allosteric modulators are listed separately. The positive allosteric modulators most often act as ‘potentiators’ of an orthosteric agonist response, without significantly activating the receptor in the absence of agonist.
A human ubiquitin carboxyl extension protein functions in yeast. (1990)

The ability of the human ubiquitin carboxyl extension protein (HUBCEP80) to functionally replace its yeast homolog was determined in a ubi3 mutant of Saccharomyces cerevisiae. Expression of HUBCEP80 in ubi3 mutants resulted in processing of the fusion protein to produce free ubiquitin and extension protein, the latter of which localized specifically with the 40 S ribosomal subunit. Furthermore, expression of the human fusion protein completely alleviated the phenotypic deficiencies found in ubi3 mutants, including slow growth, abnormal ribosomal RNA processing, and correspondingly low levels of 40 S ribosomal subunits. Finally, expression of the extension protein alone was much less efficient in complementing the ubi3 mutant phenotype as compared with expression of the normal ubiquitin-fused extension protein. In the latter case, cells were found to contain at least 5-fold more extension protein, suggesting that ubiquitin either increased translational efficiency of the HUBCEP80 transcript or increased the stability of the processed extension protein.
The Dopamine D2, but not D3or D4, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice (1999)

Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D2-like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used genetically altered strains of "knock-out" mice lacking the DA D2, D3, or D4 receptors. We tested the effects of each knock-out on both the phenotypic expression of PPI and the disruption of PPI produced by the indirect DA agonist d-amphetamine (AMPH). No phenotypic differences in PPI were observed at baseline. AMPH significantly disrupted PPI in the D2 (+/+) mice but had no effect in the D2 (-/-) mice. After AMPH treatment, both DA D3 and D4 receptor (+/+) and (-/-) mice had significant disruptions in PPI. These findings indicate that the AMPH-induced disruption of PPI is mediated via the DA D2 receptor and not the D3 or D4 receptor subtypes. Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia.
DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening (2016)

Human diseases are often diagnosed by determining levels of relevant enzymes and treated by enzyme inhibitors. We describe an assay suitable for both ultrasensitive enzyme quantification and quantitative inhibitor screening with unpurified enzymes. In the DNA-linked Inhibitor ANtibody Assay (DIANA), the target enzyme is captured by an immobilized antibody, probed with a small-molecule inhibitor attached to a reporter DNA and detected by quantitative PCR. We validate the approach using the putative cancer markers prostate-specific membrane antigen and carbonic anhydrase IX. We show that DIANA has a linear range of up to six logs and it selectively detects zeptomoles of targets in complex biological samples. DIANA's wide dynamic range permits determination of target enzyme inhibition constants using a single inhibitor concentration. DIANA also enables quantitative screening of small-molecule enzyme inhibitors using microliters of human blood serum containing picograms of target enzyme. DIANA's performance characteristics make it a superior tool for disease detection and drug discovery.
Codeposition Modification of Cation Exchange Membranes with Dopamine and Crown Ether To Achieve High K+ Electrodialysis Selectivity (2019)

Surface modification has been proven to be an effective approach for ion exchange membranes to achieve separation of counterions with different valences by altering interfacial construction of membranes to improve ion transfer performance. In this work, we have fabricated a series of novel cation exchange membranes (CEMs) by modifying sulfonated polysulfone (SPSF) membranes via codeposition of mussel-inspired dopamine (DA) and 4'-aminobenzo-15-crown-5 (ACE), followed by glutaraldehyde cross-linking, aiming at achieving selective separation of specific cations. The as-prepared membranes before and after modification were systematically characterized in terms of their structural, physicochemical, electrochemical, and electrodialytic properties. In the electrodialysis process, the modified membranes exhibit distinct perm selectivity to K<sup>+</sup> ions in binary (K<sup>+</sup>/Li<sup>+</sup>, K<sup>+</sup>/Na<sup>+</sup>, K<sup>+</sup>/Mg<sup>2+</sup>) and ternary (K<sup>+</sup>/Li<sup>+</sup>/Mg<sup>2+</sup>) systems. In particular, at a constant current density of 5.0 mA·cm<sup>-2</sup>, modified membrane M-co-0.50 shows significantly prominent perm selectivity [Formula: see text] in the K<sup>+</sup>/Mg<sup>2+</sup> system and M-co-0.75 exhibits remarkable performance in the K<sup>+</sup>/Li<sup>+</sup> system [Formula: see text], superior to commercial monovalent-selective CEM (CIMS, [Formula: see text], [Formula: see text]). Besides, in the K<sup>+</sup>/Li<sup>+</sup>/Mg<sup>2+</sup> ternary system, K<sup>+</sup> flux reaches 30.8 nmol·cm<sup>-2</sup>·s<sup>-1</sup> for M-co-0.50, while it reaches 25.8 nmol·cm<sup>-2</sup>·s<sup>-1</sup> for CIMS. It possibly arises from the effects of pore-size sieving and the synergistic action of electric field driving and host-guest molecular recognition of ACE and K<sup>+</sup> ions. This study can provide new insights into the separation of specific alkali metal ions, especially on reducing influence of coexisting cations K<sup>+</sup> and Na<sup>+</sup> on Li<sup>+</sup> ion recovery from salt lake and seawater.
Supplementary Figures S1-S9 from M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment (2023)

&lt;p&gt;Effects of α-M-CSFR Ab treatment on Ly6Chi monocyte function (S1); Effect of M-CSFR blockade on the survival of Ly6Chi monocytes and TAM (S2); Effect of M-CSFR blockade on Ly6Chi monocyte percentages in peripheral blood, spleen and bone marrow (S3); Absolute numbers of myeloid cell subsets in tumors from isotype or α-M-CSFR Ab-treated animals (S4); Production of M-CSF, IL-34 and GM-CSF by 3LL-R tumors (S5); Effect of M-CSFR blockade on monocyte differentiation in TS/A breast carcinoma tumors (S6); M-CSFR-mediated regulation of gene expression is IL-4Rα- independent (S7); Mixed Leukocyte Reaction (MLR) by TAM subsets from isotype or α-M-CSFR Ab treated animals (S8); M-CSFR blockade enhanced the M1-like MHC-IIhi TAM gene signature independently of GM-CSFR signaling (S9).&lt;/p&gt;
Captive Continuous Inkjet (2013)

Captive continuous inkjet (CIJ) is a potentially disruptive inkjet technology recently developed in the Kodak Technology Center. The captive continuous inkjet technology is expected to deliver the best of both drop-on-demand (DOD) inkjet and continuous inkjet (CIJ) technologies: high resolution, compact size, and low cost associated with traditional DOD technologies and the high throughput and high reliability of traditional CIJ technology. In this paper, we will provide a description of this new architecture, its function and why we believe it to be advantaged over both traditional CIJ and DOD technologies. We will discuss the key technology elements with details on the design, fabrication, and characterization of captive CIJ devices, including results from simulations and experimental studies.
Widefield multifrequency fluorescence lifetime imaging using a two‐tap complementary metal‐oxide semiconductor camera with lateral electric field charge modulators (2018)

Widefield frequency-domain fluorescence lifetime imaging microscopy (FD-FLIM) measures the fluorescence lifetime of entire images in a fast and efficient manner. We report a widefield FD-FLIM system based on a complementary metal-oxide semiconductor camera equipped with two-tap true correlated double sampling lock-in pixels and lateral electric field charge modulators. Owing to the fast intrinsic response and modulation of the camera, our system allows parallel multifrequency FLIM in one measurement via fast Fourier transform. We demonstrate that at a fundamental frequency of 20 MHz, 31-harmonics can be measured with 64 phase images per laser repetition period. As a proof of principle, we analyzed cells transfected with Cerulean and with a construct of Cerulean-Venus that shows Förster Resonance Energy Transfer at different modulation frequencies. We also tracked the temperature change of living cells via the fluorescence lifetime of Rhodamine B at different frequencies. These results indicate that our widefield multifrequency FD-FLIM system is a valuable tool in the biomedical field.
Sensitivity and specificity of structural optic disc parameters in chronic glaucoma (1996)

We studied different structural optic disc parameters and their ability to discriminate between normal and glaucoma eyes using computerized raster tomography. Two hundred and seventy-six eyes of 138 normal subjects and 146 eyes of 102 glaucoma patients were examined with a raster tomographic imaging system (The Glaucoma-ScopeTM, Ophthalmic Imaging Systems, Sacramento, CA). Glaucoma eyes were classified into four groups according to their perimetric mean deviation values. Minimum rim width within the 60 degrees and 90 degrees sectors across the vertical meridian, vertical and horizontal cup-disc ratio, rim and cup area were calculated for each optic disc. Receiver operating characteristics curves were set up for comparisons of the different parameters. Representing localised changes of the optic disc, minimum rim width 60 degrees and 90 degrees showed the best separating characteristics with sensitivity values of 91% at a fixed specificity of 90%, followed by vertical cup-disc ratio. Global indices like cup and rim area and horizontal cup-disc ratio showed the poorest separation. These differences were particularly obvious in the group with mild to moderate glaucomatous visual field defects. Thus, global parameters were less likely to detect early focal glaucomatous optic nerve head changes, than parameters representing localised changes.
NMR imaging of solids with a spatially selective receiver coil (1990)

A new method of NMR imaging suitable for solids is introduced which takes advantage of the spatial selectivity of a specially constructed receiver coil. The probe consists of a homogeneous transmitter coil which is larger than the sample, and an inhomogeneous receiver coil which is only sensitive to a thin slice of the sample. An image is recorded as a function of the position of the sample in the receiver coil while applying a pulse cycle which eliminates all line broadening mechanisms. Since the spins experience no spatially dependent fields or interactions, the entire sample reacts uniformly to this experiment, and the only limitation to the obtained resolution is the spatial selectivity of the receiver coil. This approach is a candidate for slice selection as well as the 1D imaging for which it is demonstrated. Two- and three-dimensional extensions are discussed.
Deducing queueing from transactional data: the queue inference engine, revisited (1990)

R. Larson (1990) proposed a method to statistically infer the expected transient queue length during a busy period with Poisson arrival in O(n/sup 5/) solely from the n starting and stopping times of each customer's service during the busy period. Here, the authors develop a novel O(n/sup 3/) algorithm which uses those data to deduce transient queue lengths as well as the waiting times of each customer in the busy period. In a manner analogous to the Kalman filter, they also develop an O(n) online algorithm to dynamically update the current estimates for queue lengths after each departure. Moreover, they generalize their algorithms for the case of a time-varying Poisson process and also for the case of i.i.d. interarrival times with an arbitrary distribution. Computational results that exhibit the speed and accuracy of these algorithms are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>