gebhart/patrepeval huggingface dataset:
Acoustic emission and stiction analysis of patterned laser textured media (1999)

The take off behavior of pico and nano sliders is investigated in the time and frequency domain using acoustic emission analysis. Laser textured disks with high and low bump densities and with various bump heights were fabricated. W-shaped and V-shaped laser bumps were produced in "row" and "column" like patterns. For these matrix arranged bump patterns, the bump pattern frequency, corresponding to the bump spacing, was found in the spectrum of the AE signal. A smoother and faster slider take-off was observed to occur if the circumferential spacing between laser bumps was reduced relative to the radial spacing. Also, a reduced bump height was found to decrease the take-off time. The stiction force during startup was found to be reduced for low density bump patterns. Torsional and bending mode excitations of the slider-body were observed to occur primarily with high density patterns. The rms acoustic emission signal was found to be generally lower for low density bump patterns than for high density patterns.
Role of salivary protease activity in adherence of gram-negative bacilli to mammalian buccal epithelial cells in vivo. (1981)

Serious illness is accompanied by markedly increased susceptibility to colonization of the respiratory tract by gram-negative bacilli and an increase in the number of such organisms which adhere to regional epithelial cells during incubation in vitro. Trypsinization of cells from normal subjects causes a similar increase in bacillary adherence. We studied bacillary adherence to buccal cells in vitro, protease activity of upper respiratory secretions with a fibrin plate technique, and the amount of fibronectin on the surface of buccal cells with a direct radioimmunobinding assay. Among 10 patients seriously ill with acute respiratory failure bacillary adherence to buccal cells and protease activity in secretions were increased compared with controls and cell-surface fibronectin was decreased; all patients were colonized in vivo with gram-negative bacilli. These changes were persistent and 80% of the patients died. Serial determinations were made in eight patients undergoing coronary artery bypass surgery. Following surgery, protease activity and bacillary adherence increased and cell-surface fibronectin decreased; 38% of coronary artery bypass patients became colonized. In these uncomplicated patients the changes observed were transient, largely returning to normal by the third postoperative day. Increased protease activity of secretions and alterations in epithelial cell surfaces as reflected by loss of buccal cell-surface fibronectin occur swiftly after major illness and appear to underlie enhanced cell adherence of bacilli and colonization of the upper respiratory tract. These findings suggest new approaches to the prevention of nosocomial pneumonia.
Comparing the performance of web server architectures (2007)

In this paper, we extensively tune and then compare the performance of web servers based on three different server architectures. The μserver utilizes an event-driven architecture, Knot uses the highly-efficient Capriccio thread library to implement a thread-per-connection model, and WatPipe uses a hybrid of events and threads to implement a pipeline-based server that is similar in spirit to a staged event-driven architecture (SEDA) server like Haboob. We describe modifications made to the Capriccio thread library to use Linux's zero-copy sendfile interface. We then introduce the SY mmetric Multi-Processor Event Driven (SYMPED) architecture in which relatively minor modifications are made to a single process event-driven (SPED) server (the μserver) to allow it to continue processing requests in the presence of blocking due to disk accesses. Finally, we describe our C++ implementation of WatPipe, which although utilizing a pipeline-based architecture, excludes the dynamic controls over event queues and thread pools used in SEDA. When comparing the performance of these three server architectures on the workload used in our study, we arrive at different conclusions than previous studies. In spite of recent improvements to threading libraries and our further improvements to Capriccio and Knot, both the event-based μserver and pipeline-based Wat-Pipe server provide better throughput (by about 18%). We also observe that when using blocking sockets to send data to clients, the performance obtained with some architectures is quite good and in one case is noticeably better than when using non-blocking sockets.
Chemistry of Heterometallic Cluster Compounds Prepared by Condensation of Group 6 Metal Acetylide and Group 8 Binary Carbonyl Complexes (1992)

Abstract The chemistry of trinuclear and tetranuclear heterometallic acetylide complexes, LWOs 3 (CO) 11 (CCR) and LWM 2 (CO) 8 (CCR), L = Cp and Cp*; M = Os and Ru, is presented. Included in this account are syntheses, characterization and reactivity, with a particular focus on reactions with disubstituted alkyne molecules. The reactivity and fluxionality of these acetylide complexes provides a plausible model for ligand‐mediated metal‐core rearrangement and the transformation of small organic molecules on catalytic metal surfaces.
Performance Evaluation of a 60 GHz Radio-over-Fiber System Employing MIMO and OFDM Modulation (2013)

Multiple-input-multiple-output (MIMO) technique for wireless communications is extensively used these days, especially to increase the spectral efficiency of new wireless communication systems like LTE, WiMAX, etc. MIMO in combination with robust modulation techniques like orthogonal frequency division multiplexing (OFDM) provides a good solution for high data rate wireless links. In this paper, the performance of MIMO for a 60 GHz OFDM radio over fiber link is analyzed. System performance of the MIMO system for different antenna spacing is also studied. Using the optimum system parameters, a MIMO OFDM wireless link of up to 51 Gb/s was successfully demonstrated at 60 GHz in a bandwidth of <7 GHz, with a wireless transmission distance of up to 4 m and optical fiber transmission of \>1 km. To our knowledge this is the highest data rate demonstrated in the 7 GHz band of 60 GHz.
The alternatively spliced CD64 transcript FcγRIb2 does not specify a surface‐expressed isoform (1999)

Three highly homologous genes (A, B and C) and six transcripts have been identified for the class I human IgG receptor (CD64). The hFcgammaRIa1 isoform encodes the prototypic high-affinity receptor for IgG. The alternatively spliced hFcgammaRIb2 transcript was postulated to exist as a second surface-expressed CD64 isoform on myeloid cells. In this report we assessed this proposed role for hFcgammaRIb2 in detail. As CD64 monoclonal antibodies might not recognize hFcgammaRIb2, we tagged the receptor with an hemagglutinin tag and transfected hFcgammaRIb2tag in the presence of FcR gamma-chain into IIA1.6 cells. Both transcript and protein of hFcgammaRIb2tag were clearly present in transfectants. However, in contrast to the (control) hFcgammaRIa1tag, no surface expression of hFcgammaRIb2tag was detectable with a tag-specific monoclonal antibody. Confocal scan laser microscopy revealed hFcgammaRIb2tag to be retained in the endoplasmic reticulum, resulting in absent plasma membrane expression. These results show hFcgammaRIb2 neither to be surface expressed, nor to represent a separate CD64 isoform. This finding, furthermore, implicates that other FcR transcripts defined at the mRNA level may not represent true FcR isoforms either.
Oxygen-17 NMR as a tool for studying oxygenated transition-metal derivatives: first direct oxygen-17 NMR observations of transition-metal-bonded peroxidic oxygen atoms. Evidence for the absence of oxo-peroxo oxygen exchange in molybdenum(VI) compounds (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen-17 NMR as a tool for studying oxygenated transition-metal derivatives: first direct oxygen-17 NMR observations of transition-metal-bonded peroxidic oxygen atoms. Evidence for the absence of oxo-peroxo oxygen exchange in molybdenum(VI) compoundsMichele Postel, Christian Brevard, Henri Arzoumanian, and Jean G. RiessCite this: J. Am. Chem. Soc. 1983, 105, 15, 4922–4926Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00353a014https://doi.org/10.1021/ja00353a014research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nonlinear Superconducting Metamaterials in Free-Space at mm-wave Frequencies (2014)

Superconducting metamaterials show the promise of low loss, compact size and extreme tunability and nonlinearity, allowing for new applications. Most demonstrations of these metamaterials have been conducted in waveguide geometries, either in co-planar form or three-dimensional single-conductor structures. Here we demonstrate for the first time a widely tunable superconducting metamaterial operating under the free-space illumination of a quasi-optical beam in the 100 GHz regime. The meta-atoms are Radio Frequency Superconducting QUantum Interference Devices (RF SQUIDs) that form compact self-resonant objects endowed with the nonlinearity of the Josephson effect. The metamaterial is tuned with dc magnetic flux, temperature and mm-wave power, and holds promise for a new generation of mm-wave agile devices.&lt;br/&gt;&lt;br/&gt;This work is supported by the NSF-GOALI and OISE programs through grant #ECCS-1158644, and CNAM.
Independence of Valence and Reward in Emotional Word Processing: Electrophysiological Evidence (2013)

BOTH EMOTION AND REWARD ARE PRIMARY MODULATORS OF COGNITION: emotional word content enhances word processing, and reward expectancy similarly amplifies cognitive processing from the perceptual up to the executive control level. Here, we investigate how these primary regulators of cognition interact. We studied how the anticipation of gain or loss modulates the neural time course (event-related potentials, ERPs) related to processing of emotional words. Participants performed a semantic categorization task on emotional and neutral words, which were preceded by a cue indicating that performance could lead to monetary gain or loss. Emotion-related and reward-related effects occurred in different time windows, did not interact statistically, and showed different topographies. This speaks for an independence of reward expectancy and the processing of emotional word content. Therefore, privileged processing given to emotionally valenced words seems immune to short-term modulation of reward. Models of language comprehension should be able to incorporate effects of reward and emotion on language processing, and the current study argues for an architecture in which reward and emotion do not share a common neurobiological mechanism.
An Easy Access to 7-Methyl-2-naphthalenecarbonitrile (2005)

A practical and cost-effective procedure has been developed for the synthesis of 7-methyl-2-naphthalenecarbonitrile, the precursor of the anticoagulant agents YM-60828 or YM-96765. This new route generates the key intermediate in only two steps from readily available 3-cyanopropionaldehyde dimethyl acetal and m-tolualdehyde, without requiring chromatographic purification. The synthesis involves condensation of the cyano derivative with the aldehyde and subsequent cyclodehydration.
Discrete model of DCS controlled half-bridge with current doubler for digital controller design (2005)

In this paper, a discrete model is developed for DCS controlled half-bridge topology with current-doubler to facilitate digital controller design when operating at high switching frequencies. The discrete model is derived and then compared with the classical continuous model. The model is represented in the versatile state-space form, which allows the application of a wide range of modern and classical control theories. The pulse transfer function for the modulator input to converter output voltage is derived for use in voltage mode control. To verify the theoretical frequency response predicted by the presented model, a laboratory prototype is built
Abstract 1753: KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro. (2013)

Abstract Pancreatic cancer is an aggressive malignancy and one of the leading causes of cancer deaths. The high mortality rate is mostly due to the lack of appropriate tools for the early detection of the disease and a shortage of effective therapies. We have previously shown that karyopherin alpha 7 (KPNA7) is frequently amplified and overexpressed in pancreatic cancer. KPNA7 is a recently characterized member of the alpha karyopherin family of nuclear import receptors. The nuclear import machinery is composed of a complex network of proteins required for the appropriate transport of proteins from the cytoplasm to the nucleus. Abnormal function of this machinery leads to incorrect localization of nuclear proteins and disturbances in cellular homeostasis, which may subsequently contribute to the development of various diseases including cancer. Indeed, previous evidence has linked members of the karyopherin alpha family, especially KPNA2, to cancer pathogenesis. In this study we demonstrate that KPNA7 expression is absent in practically all normal human adult tissues but elevated in several pancreatic cancer cell lines as well as in some other cancer types. Inhibition of KPNA7 expression in AsPC-1 and Hs700T pancreatic cancer cells led to a striking reduction in cell growth due to the induction of the cell cycle regulator p21 and subsequent G1 arrest of the cell cycle. In both of these cell lines KPNA7 silencing also resulted in decreased anchorage independent growth, and additionally in the AsPC-1 cells reduced cell migration and invasion. Furthermore, in the Hs700T cells KPNA7 silencing resulted in dramatic morphological change where the cells acquired fibroblast-like shape. This phenotypic change was not explained by induction of EMT or senescence. In conclusion, our data strongly demonstrate that KPNA7 silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role of KPNA7 in human cancer. Moreover, the lack of KPNA7 expression in normal adult tissues highlights it as a potential novel therapeutic target for cancer. Further studies are needed to identify the cargo proteins transported by KPNA7. These studies are likely to reveal important new information on nuclear transport and may highlight the molecular mechanisms involved in KPNA7 mediated phenotypes in cancer cells. Citation Format: Hanna E. Rauhala, Eeva Laurila, Elisa Vuorinen, Kimmo Savinainen, Anne Kallioniemi. KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1753. doi:10.1158/1538-7445.AM2013-1753
Analysis of Microresonator-Based Logic Gate for High-Speed Optical Computing in Integrated Photonics (2019)

Microresonator modulators are commonly used as electrical-optic (EO) logic gates in computing systems on silicon photonics platform. In this article, we provide a compact analytical model to describe the switching properties of a linearly cascaded microresonator modulator array. The analytical model is verified by simulations on commercial software. Switching properties of microresonators under different modulation conditions are investigated. Furthermore, computing modules where microresonator modulators are cascaded in series are also discussed, where the model of microresonators is provided by AIM Photonics Process Design Kit (PDK). Factors that deteriorate the logic outputs are analyzed and methods to improve the accuracy of logic outputs are proposed and demonstrated with 8 microresonator modulators.
Satisfaction With Epidural and Intravenous Patient-Controlled Analgesia (2001)

Both techniques, i.v. and epidural PCA, result in high levels of satisfaction. Satisfaction with PCA can be accurately predicted in nearly three of four patients based on initial PCA route and preoperative attitudes. Additionally, maintaining the initial treatment plan can be accurately predicted based on age and preoperative attitudes. Patient expectations about pain relief should be addressed preoperatively, particularly with younger patients, for optimal results.
Flow visualization of ferromagnetic nano-particles on micro-capillary flow (2004)

Thermal behavior of ferromagnetic particles in magnetic fluids were investigated using an optical micro-scope system. Real-time visualization of the Brownian motion of particles were carried out by using micro-scope and high speed camera on micro-capillary flow. The analysis of digital images with Particle Tracking Velocimetry (PTV) was applied to investigate the thermal behavior of ferromagnetic nano particles.
Scheduling in Massive MIMO: User clustering and pilot assignment (2016)

In this paper, we consider the problem of user scheduling and pilot assignment in TDD multicell multiuser Massive MIMO systems. While in TDD systems the channel is acquired using uplink pilots, we propose a scheme that utilizes additional downlink probing in order to improve the spectral efficiency. The idea is to dynamically assign mobile users to different clusters based on the directions of their channels through the use of downlink reference beams. This will result in forcing the interference to be centered in semi-orthogonal subspaces without the need for important feedback and therefore enabling reduction of the pilot contamination effect. The scheduled users in each cluster employs orthogonal training sequences with a pilot reuse factor of 1 among the clusters. We then propose a graphical framework for pilot assignment. We show that this problem can be modeled as a max cut problem and we provide an approximation algorithm that optimizes the pilot allocation.
The Use of Prestressed CFRP-Laminates as Post-Strengthening (2000)

Conference paper written by Gregor Schwegler and Thierry Berset presented at IABSE Congress: Structural Engineering for Meeting Urban Transportation Challenges, Lucerne, Switzerland, 18-21 September 2000.
Recognition of the CDEl motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo (1991)

We have reported previously (1) two unexpected consequences of the microinjection into fertilized mouse eggs of a recombinant plasmid designated p12B1, carrying a 343 bp insert of non-repetitive mouse DNA. Injected at very low concentrations, this plasmid could be established as an extrachromosomal genetic element. When injected in greater concentration, an early arrest of embryonic development resulted. In the present work, we have studied this toxic effect in more detail by microinjecting short synthetic oligonucleotides with sequences from the mouse insert. Lethality was associated with the nucleotide sequence GTCACATG, identical with the CDEl element of yeast centromeres. Development of injected embryos was arrested between the one-cell and the early morula stages, with abnormal structures and DNA contents. Electrophoretic mobility shift and DNAse foot-printing assays demonstrated the binding of mouse nuclear protein(s) to the CDEl-like box. Base changes within the CDEl sequence prevented both the toxic effects in embryos and the formation of protein complex in vitro, suggesting that protein binding at such sites in chromosomal DNA plays an important role in early development.
Establishing a Blueprint for nature-based Products Development and Conservation for the Philippines (2018)

Background. Many of the leading causes of mortality and morbidity in the Philippines are controllable with naturebased products, either as agents of intervention, or prevention, as nutritional supplements, or for the control of side-effects of medications. The different R&amp;D programs on nature-based products in the Philippines are usually conducted in isolation, or through silos. These often lead to products that are shortsighted, duplicate products, or products with minimal innovation, not readily applicable to population and environmental sustainability.&#x0D; Objective. The study aimed to draft an internationally benchmarked and integrated blueprint for a population health- and environmental health-led nature-based product development and conservation for the Philippines.&#x0D; Methods. The methodology consisted of review of literature; regional educational visits; and a series of consultative meetings with stakeholders.&#x0D; Results. The study resulted in a stakeholder-validated blueprint which assigns the Philippine Institute of Traditional and Alternative Health Care (PITAHC) to lead the way for Filipinos to produce more nature-based products that are of international quality and attuned with local health needs. The blueprint has identified “9 Optimizations” in the realization of this aspiration, including an expanded role for PITAHC, a national database, an ethical researchers list, and to produce at least five commercial products and 20 intellectual property rights within 5 years with an estimated total investment of approximately PhP 816 M.
Remote atmospheric breakdown for standoff detection using intense short laser pulse compression (2004)

A remote atmospheric breakdown (RAB) is a very rich source of ultraviolet (UV) and broadband visible light that could provide the early warning to the presence of CW/BW agents through spectroscopic detection, identification and quantification at extended standoff distances. A low-intensity negatively chirped laser pulse propagating in air compresses in time due to linear group velocity dispersion and focuses transversely due to non-linear effects resulting in rapid laser intensity increase and ionization near the focal region that can be located kilometers away from the laser system. Proof of principle laboratory experiments are being performed at the Naval Research Laboratory on the generation of RAB and the spectroscopic detection of mock BW agents. We have demonstrated pulse compression and focusing up to 105 meters in the laboratory using femtosecond pulses generated by a high power Ti:Sapphire laser. We observed nonlinear modifications to the temporal frequency chirp of the laser pulse and their effects on the laser compression and the positions of the final focus. We have generated third harmonics at 267 nm and white light in air from the compressed pulse. We have observed fluorescence emission from albumin aerosols as they were illuminated by the compressed femtosecond laser pulse.