gebhart/patrepeval huggingface dataset:
The Optical Stability of Beryllium Complexes (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Optical Stability of Beryllium ComplexesDaryle H. Busch and John C. Bailar Jr.Cite this: J. Am. Chem. Soc. 1954, 76, 21, 5352–5353Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01650a027https://doi.org/10.1021/ja01650a027research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Interobserver Agreement on PSMA PET/CT Even in the Absence of Clinical Data (2023)

Applying PSMA-RADS, concordance rates were fair to excellent, whereas relevant modifications were rarely observed after providing clinical data. As such, even in the absence of patient information, standardized frameworks still provide guidance for reading PSMA PETs. Those findings may have implications for a high throughput in a busy PET practice, where patient details cannot always be retrieved at time of scan interpretation or in the context of clinical trials or central reviews in which readers may be blinded to clinical data.
Sensing using Coded Communications Signals (2022)

&lt;p&gt;A key challenge for a common waveform for Integrated Sensing and Communications (ISAC) -- widely seen as an attractive proposition to achieve high performance for both functionalities, while efficiently utilizing available resources -- lies in leveraging information-bearing channel-coded communications signals (c.c.s) for sensing. In this paper, we investigate the sensing performance of c.c.s in (multi-user) interference-limited operation, and show that it is limited by &lt;em&gt;sidelobes&lt;/em&gt; in the range-Doppler map, whose form depends on whether the c.c.s modulates a single-carrier or OFDM waveform. While uncoded communications signals -- comprising a block of &lt;em&gt;N&lt;/em&gt; i.i.d zero-mean symbols -- give rise to &lt;em&gt;asymptotically&lt;/em&gt; (i.e., at large &lt;em&gt;N&lt;/em&gt;) &lt;em&gt;zero sidelobes&lt;/em&gt; due to the law of large numbers, it is not obvious that the same holds for c.c.s, as structured channel coding schemes (e.g., linear block codes) induce dependence across codeword symbols. In this paper, we show that c.c.s also give rise to asymptotically zero sidelobes -- for both single-carrier and OFDM waveforms -- by deriving upper bounds for the tail probabilities of the sidelobe magnitudes that decay as exp( - O(code rate x block length)). This implies that for any code rate, c.c.s are effective sensing signals that are robust to multi-user interference at &lt;em&gt;sufficiently large&lt;/em&gt; block lengths, with negligible difference in performance based on whether they modulate a single-carrier or OFDM waveform. We verify the latter implication through simulations, where we observe the sensing performance (characterized by the detection and false-alarm probabilities) of a QPSK-modulated c.c.s (code rate = 120/1024, block length = 1024 symbols) to match that of a comparable interference-free FMCW waveform even at high interference levels (signal-to-interference ratio of -11dB), for both single-carrier and OFDM waveforms.&lt;/p&gt;
Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance (2016)

Our imaging studies, using PET probes specific to EGFR and HER3, show that changes in RTK expression indicative of resistance to PI3K and AKT inhibitors can be seen within days of therapy initiation and are of sufficient magnitude as to allow reliable clinical interpretation. Noninvasive PET monitoring of these RTK feedback loops should help to rapidly assess resistance to PI3K and AKT inhibitors and guide selection of an appropriate combinatorial therapeutic regimen on an individual patient basis.
Pathway Complexity in π-Conjugated Materials (2013)

To arrive at functional organic materials with optimal molecular organization, control over the aggregation process is a prerequisite. Often, however, multiple pathways are involved that compete for the same molecular building block, a phenomenon known as pathway complexity. As a result, the material—made from small molecules or polymers—can get entrapped in a metastable pathway while a more stable but slower formed morphology is aimed for. Vice versa, the equilibrium state can be obtained easily, but another, less stable morphology is desired as it has more interesting properties. In both cases, the solution processing, starting from molecularly dissolved material, should be optimized to select the desired aggregation pathway. This Perspective aims to outline the importance of mechanistic insights derived from self-assembly of 1D fibers in diluted solutions to unravel and control aggregation pathways involved in the processing of π-conjugated materials.
Immunity to Fungi (2001)

Abstract The medically important fungi are a diverse group of pathogens that employ a variety of virulence strategies to establish themselves in the host. Successful host defence against fungi requires collaboration between innate and acquired humoral and cellular immune mechanisms.
Modulation of cell growth and apoptosis response in human prostate cancer cells supplemented with tocotrienols (2008)

Abstract Previous studies have shown that tocotrienols are powerful growth inhibitors and potent inducers of apoptosis in human breast cancer cells. The objective of the current study was to examine effects of tocotrienols on apoptotic signals in androgen‐independent PC‐3 human prostate cancer cells. We investigated the effects of the tocotrienol‐rich fraction (TRF) from palm oil, α‐tocopherol (αT), α‐tocotrienol (αT 3 ), γ‐tocotrienol (γT 3 ) and δ‐tocotrienol (δT 3 ) on PC‐3 cell growth. TRF inhibited PC‐3 growth with a nonlinear response, with complete growth suppression at 10 µg/mL. δT 3 and γT 3 showed complete cell inhibition at 8 µg/mL whilst αT had no effect. δT 3 and γT 3 showed the most promise in the cell growth assays, and all subsequent experiments were performed with δT 3 , TRF and αT. TRF and δT 3 at 8 µg/mL induced apoptosis in PC‐3 cells after 48 h of treatment. In addition, TRF and δT 3 treatments were able to affect the cell cycle, with accumulation in the S phase, G2 phase block and increases in SubG1 by 72 h. We then proceeded to investigate the expression levels of Fas receptor and Fas ligand, caspase 8, caspase 3 and bax in PC‐3 cells following treatment with tocotrienols using real‐time PCR and Western blot methods. TRF and δT 3 at 8 µg/mL increased Fas ligand expression levels by 368 and 456%, respectively, after 24 h and Fas receptor expression levels by 210% and 356%, respectively, after 48 h. TRF‐ and δT 3 ‐treated PC‐3 cells overexpressed caspase 8 and bax protein after 24 h, and caspase 3 after 48 h. In conclusion, tocotrienols are able to induce apoptosis and cell cycle arrest in PC‐3 cells, with increased expression of Fas receptor, Fas ligand, caspase 8, caspase 3 and bax, suggesting a potential role in chemoprevention of prostate cancer.
Reconciling D+1 Masking In Hardware And Software (2017)

The continually growing number of security-related autonomous devices requires efficient mechanisms to counteract low-cost side-channel analysis (SCA) attacks. Masking provides high resistance against SCA at an adjustable level of security. A high level of SCA resistance, however, goes hand in hand with an increasing demand for fresh randomness which drastically increases the implementation costs. Since hardware based masking schemes have other security requirements than software masking schemes, the research in these two fields has been conducted quite independently over the last ten years. One important practical difference is that recently published software schemes achieve a lower randomness footprint than hardware masking schemes. In this work we combine existing software and hardware masking schemes into a unified masking algorithm. We demonstrate how to protect software and hardware implementations using the same masking algorithm, and for lower randomness costs than the separate schemes. Especially for hardware implementations the randomness costs can in some cases be halved over the state of the art. Theoretical considerations as well as practical implementation results are then used for a comparison with existing schemes from different perspectives and at different levels of security.
33.1: Channel‐Etched C‐Axis Aligned Crystalline Oxide Semiconductor FET Using Cu Wiring (2014)

Abstract A channel‐etched IGZO field‐effect transistor (FET) using Cu wiring was fabricated. Because little Cu is diffused into a c‐axis aligned crystalline oxide semiconductor (CAAC‐OS), which is c‐axis aligned crystalline IGZO, the use of the CAAC‐OS provides favorable characteristics for a channel‐etched FET.
Digital Microfluidics for Automated Proteomic Processing (2009)

Clinical proteomics has emerged as an important new discipline, promising the discovery of biomarkers that will be useful for early diagnosis and prognosis of disease. While clinical proteomic methods vary widely, a common characteristic is the need for (i) extraction of proteins from extremely heterogeneous fluids (i.e. serum, whole blood, etc.) and (ii) extensive biochemical processing prior to analysis. Here, we report a new digital microfluidics (DMF) based method integrating several processing steps used in clinical proteomics. This includes protein extraction, resolubilization, reduction, alkylation and enzymatic digestion. Digital microfluidics is a microscale fluid-handling technique in which nanoliter-microliter sized droplets are manipulated on an open surface. Droplets are positioned on top of an array of electrodes that are coated by a dielectric layer - when an electrical potential is applied to the droplet, charges accumulate on either side of the dielectric. The charges serve as electrostatic handles that can be used to control droplet position, and by biasing a sequence of electrodes in series, droplets can be made to dispense, move, merge, mix, and split on the surface. Therefore, DMF is a natural fit for carrying rapid, sequential, multistep, miniaturized automated biochemical assays. This represents a significant advance over conventional methods (relying on manual pipetting or robots), and has the potential to be a useful new tool in clinical proteomics. Mais J. Jebrail, Vivienne N. Luk, and Steve C. C. Shih contributed equally to this work. Sergio L. S. Freire's current address is at the University of the Sciences in Philadelphia located at 600 South 43rd Street, Philadelphia, PA 19104.
ChemInform Abstract: Biocatalytic Deracemization of 1,4‐Benzodiazepines in the Synthesis of Enantiomerically Pure Serine. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Distinct Innate Immune Phagocyte Responses to Aspergillus fumigatus Conidia and Hyphae in Zebrafish Larvae (2014)

Aspergillus fumigatus is the most common filamentous fungal pathogen of immunocompromised hosts, resulting in invasive aspergillosis (IA) and high mortality rates. Innate immunity is known to be the predominant host defense against A. fumigatus; however, innate phagocyte responses to A. fumigatus in an intact host and their contributions to host survival remain unclear. Here, we describe a larval zebrafish A. fumigatus infection model amenable to real-time imaging of host-fungal interactions in live animals. Following infection with A. fumigatus, innate phagocyte populations exhibit clear preferences for different fungal morphologies: macrophages rapidly phagocytose conidia and form aggregates around hyphae, while the neutrophil response is dependent upon the presence of hyphae. Depletion of macrophages rendered host larvae susceptible to invasive disease. Moreover, a zebrafish model of human leukocyte adhesion deficiency with impaired neutrophil function also resulted in invasive disease and impaired host survival. In contrast, macrophage-deficient but not neutrophil-deficient larvae exhibited attenuated disease following challenge with a less virulent (ΔlaeA) strain of A. fumigatus, which has defects in secondary metabolite production. Taking these results together, we have established a new vertebrate model for studying innate immune responses to A. fumigatus that reveals distinct roles for neutrophils and macrophages in mediating host defense against IA.
Towards Automated Analysis of Minirhizotron Images (2005)

The ability to do robust, meaningful research with minirhizotron images is currently limited by the amount of time that can be spent by a human expert classifying the data. This poster focuses on presenting progress along a path towards the automated analysis of these images. It shows custom software that has been developed to aid in the classification process and filters which locate structures of interest in some cases.
Automatic Continuity of Concave Functions (1988)

A necessary and sufficient condition is given that a semicontinuous, nonnegative, concave function on a finite dimensional closed convex set $X$ necessarily be continuous at a point ${x_0} \in X$. Application of this criterion at all points of $X$ yields a characterization, due to Gale, Klee and Rockafellar, of convex polyhedra in terms of continuity of their convex functions.
The impact of software engineering research on modern programming languages (2005)

Software engineering research and programming language design have enjoyed a symbiotic relationship, with traceable impacts since the 1970s, when these areas were first distinguished from one another. This report documents this relationship by focusing on several major features of current programming languages: data and procedural abstraction, types, concurrency, exceptions, and visual programming mechanisms. The influences are determined by tracing references in publications in both fields, obtaining oral histories from language designers delineating influences on them, and tracking cotemporal research trends and ideas as demonstrated by workshop topics, special issue publications, and invited talks in the two fields. In some cases there is conclusive data supporting influence. In other cases, there are circumstantial arguments (i.e., cotemporal ideas) that indicate influence. Using this approach, this study provides evidence of the impact of software engineering research on modern programming language design and documents the close relationship between these two fields.
Oblique projector rendering on planar surfaces for a tracked user (1999)

No abstract available.
Learning Dimensional Analysis through Collaboratively Working with Manipulatives (2011)

Dimensional analysis is traditionally one of the first topics covered in a general chemistry course. Chemists use dimensional analysis as a tool to keep track of units and guide them through calculations. Although unit conversions are taught in a variety of subjects over several grade levels, many students have not mastered this topic by the time they enter college. To properly equip beginning chemistry students, a collaborative active-learning activity was developed. This article describes the activity and reports data of the effects it had on students’ performance in a first-semester general chemistry course at a large research institution.
Optimisation sur cycle de vie de systèmes photovoltaïques autonomes. Influence des profils de consommation (2007)

National audience
The Scanning Fiber Endoscope: A Novel Surgical and High-Resolution Imaging Device for Intracranial Neurosurgery (2022)

Although the SFE has been shown to be a superior device for imaging, here we demonstrate its first use as a potential therapeutic device in intracranial neurosurgery.
GHVR: One-to-One Gradient-Height Vector Routing in Wireless Mesh Networks (2009)

This paper addresses the problem of routing packets between any nodes in a wireless mesh network (WMN) equipped with a set of reference landmarks. These reference landmarks are pre-selected Internet gateways or special nodes that broadcast beacon messages periodically. WMN nodes are then assigned multiple gradient-based coordinates, which are heights relative to the landmarks. These multiple heights of each node are treated as if they were the actual multi-dimensional geographic locations of that node. The proposed routing protocol, called GHVR, runs geographic routing with these multi-dimensional geographic locations. Unlike other similar approaches that use discrete hop counts to the landmarks, GHVR uses continuous heights expressed in real numbers. Our ns-2 simulation results demonstrate that GHVR requires fewer landmarks and improves routing performance by almost a factor of 2 over that of using the discrete hop-count coordinate.
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310 (2021)

Na<sub>v</sub>1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical profile of GDC-0276 (<b>1</b>) and GDC-0310 (<b>2</b>), selective Na<sub>v</sub>1.7 inhibitors that have completed Phase 1 trials. Our initial search focused on close-in analogues to early compound <b>3</b>. This resulted in the discovery of GDC-0276 (<b>1</b>), which possessed improved metabolic stability and an acceptable overall pharmacokinetics profile. To further derisk the predicted human pharmacokinetics and enable QD dosing, additional optimization of the scaffold was conducted, resulting in the discovery of a novel series of N-benzyl piperidine Na<sub>v</sub>1.7 inhibitors. Improvement of the metabolic stability by blocking the labile benzylic position led to the discovery of GDC-0310 (<b>2</b>), which possesses improved Na<sub>v</sub> selectivity and pharmacokinetic profile over <b>1</b>.
Coupling of a dipolar emitter into one-dimensional surface plasmon (2013)

Quantum plasmonics relies on a new paradigm for light-matter interaction. It benefits from strong confinement of surface plasmon polaritons (SPP) that ensures efficient coupling at a deep subwavelength scale, instead of working with a long lifetime cavity polariton that increases the duration of interaction. The large bandwidth and the strong confinement of one dimensional SPP enable controlled manipulation of a nearby quantum emitter. This paves the way to ultrafast nanooptical devices. However, the large SPP bandwidth originates from strong losses so that a clear understanding of the coupling process is needed. In this report, we investigate in details the coupling between a single emitter and a plasmonic nanowire, but also SPP mediated coupling between two emitters. We notably clarify the role of losses in the Purcell factor, unavoidable to achieve nanoscale confinement down to 10(-4)(λ/n)(3). Both the retarded and band-edge quasi-static regimes are discussed.
Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library. (2009)

Phage antibody library is a promising tool for rapidly creating in vitro single-chain Fv (scFv) antibodies to various antigens. The scFv can also act like a subcellularly-expressed antibody, known as intrabody, and can either be used as a novel research tool or used efficiently for targeted molecular therapy. However, there are only a few existing reports about the successful expression of scFvs as functional antibodies in the cell, mainly because poor quality scFv phage antibody libraries were used to isolate the intrabody clones. The aim of this study was to isolate intrabody-forming scFv clones from the nonimmune scFv phage antibody library we have generated. Using this library, we isolated a scFv clone against the apoptosis-related intracellular protein Bid in two weeks. To evaluate the intrabody-forming quality of this anti-Bid scFv clone, we expressed it in cultured mammalian cells after fusing it with the fluorescent protein Venus. The expression of the soluble form of anti-Bid scFv-Venus fusion protein was confirmed by fluorescence microscopy analysis. These results show that our scFv phage library is not only optimized for antibody production but can also be used to efficiently generate intrabodies.
Antibiotics for the prevention of infections in cancer patients receiving myelosuppressive chemotherapy or haematopoetic stem cell transplantation (2016)

Authors have made no progress with this protocol in several years. New authors are being sought to take over this protocol.
Supplemental Table 1 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers (2023)

&lt;p&gt;The antibodies used in this study.&lt;/p&gt;
Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons (2016)

Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox homeostasis. For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in mammalian neurons, inhibits both enzymatic activity and protective function against oxidative stress. Here, using in vitro and in vivo approaches, we identify a role and reaction mechanism of the reductase sulfiredoxin (Srxn1) as an enzyme that denitrosylates (thus removing -SNO) from Prx2 in an ATP-dependent manner. Accordingly, by decreasing S-nitrosylated Prx2 (SNO-Prx2), overexpression of Srxn1 protects dopaminergic neural cells and human-induced pluripotent stem cell (hiPSC)-derived neurons from NO-induced hypersensitivity to oxidative stress. The pathophysiological relevance of this observation is suggested by our finding that SNO-Prx2 is dramatically increased in murine and human Parkinson's disease (PD) brains. Our findings therefore suggest that Srxn1 may represent a therapeutic target for neurodegenerative disorders such as PD that involve nitrosative/oxidative stress.