gebhart/patrepeval huggingface dataset:
Electrochemical Modulation of Carbon Monoxide‐Mediated Cell Signaling (2021)

Despite the critical role played by carbon monoxide (CO) in physiological and pathological signaling events, current approaches to deliver this messenger molecule are often accompanied by off-target effects and offer limited control over release kinetics. To address these challenges, we develop an electrochemical approach that affords on-demand release of CO through reduction of carbon dioxide (CO<sub>2</sub> ) dissolved in the extracellular space. Electrocatalytic generation of CO by cobalt phthalocyanine molecular catalysts modulates signaling pathways mediated by a CO receptor soluble guanylyl cyclase. Furthermore, by tuning the applied voltage during electrocatalysis, we explore the effect of the CO release kinetics on CO-dependent neuronal signaling. Finally, we integrate components of our electrochemical platform into microscale fibers to produce CO in a spatially-restricted manner and to activate signaling cascades in the targeted cells. By offering on-demand local synthesis of CO, our approach may facilitate the studies of physiological processes affected by this gaseous molecular messenger.
Eni Carbon Silicates: Innovative Hybrid Materials for Room-Temperature Gas Sensing (2017)

The purpose of this work was to satisfy both materials and technological sciences, on the one hand implementing innovative hybrid materials referred to as ECS (Eni Carbon Silicate) in gas sensors manufacturing, and on the other hand verifying their possible operation at room temperature as a technological progress. The ECS-14 and ECS-13 phases were employed as functional materials for films deposited by drop coating onto alumina substrates. Room-temperature gas tests were performed to study their potential sensing properties. In humidity conditions, the ECS-14 based sensor showed outstanding performance and a complete calibration vs. moisture concentration was obtained.
LTE-advanced: next-generation wireless broadband technology [Invited Paper (2010)

LTE Release 8 is one of the primary broadband technologies based on OFDM, which is currently being commercialized. LTE Release 8, which is mainly deployed in a macro/microcell layout, provides improved system capacity and coverage, high peak data rates, low latency, reduced operating costs, multi-antenna support, flexible bandwidth operation and seamless integration with existing systems. LTE-Advanced (also known as LTE Release 10) significantly enhances the existing LTE Release 8 and supports much higher peak rates, higher throughput and coverage, and lower latencies, resulting in a better user experience. Additionally, LTE Release 10 will support heterogeneous deployments where low-power nodes comprising picocells, femtocells, relays, remote radio heads, and so on are placed in a macrocell layout. The LTE-Advanced features enable one to meet or exceed IMT-Advanced requirements. It may also be noted that LTE Release 9 provides some minor enhancement to LTE Release 8 with respect to the air interface, and includes features like dual-layer beamforming and time-difference- of-arrival-based location techniques. In this article an overview of the techniques being considered for LTE Release 10 (aka LTEAdvanced) is discussed. This includes bandwidth extension via carrier aggregation to support deployment bandwidths up to 100 MHz, downlink spatial multiplexing including single-cell multi-user multiple-input multiple-output transmission and coordinated multi point transmission, uplink spatial multiplexing including extension to four-layer MIMO, and heterogeneous networks with emphasis on Type 1 and Type 2 relays. Finally, the performance of LTEAdvanced using IMT-A scenarios is presented and compared against IMT-A targets for full buffer and bursty traffic model.
Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. (1997)

Glutathione-independent prostaglandin D synthase (PGDS) is an enzyme responsible for biosynthesis of prostaglandin D2 in the CNS and is identical to a major cerebrospinal fluid protein, beta-trace. Although PGDS has been identified recently in rat leptomeninges, little information is available about human meninges or meningiomas. Here, we report PGDS to be expressed consistently in 10 human arachnoid and arachnoid villi and in 21 meningiomas by immunohistochemistry, Western blot, and reverse transcription (RT)-PCR analyses. In arachnoid, PGDS immunoreactivity was seen in arachnoid barrier cells but was negligible in arachnoid trabecula and pia mater. In contrast, in arachnoid villi, PGDS was seen in core arachnoid cells rather than in the cap cell cluster or arachnoid cell layer. Meningioma cells also showed intense immunoreactivity in the perinuclear region, and it was often concentrated within meningocytic whorls and around calcifying psammoma bodies. Immunoelectron microscopic data, when compared with the ultrastructure, showed that PGDS was localized at rough endoplasmatic reticulum of arachnoid and meningioma cells. Western blot showed a 29 kDa immunoreactive band indicating PGDS, but the extent of expression was variable from case to case, which was compatible with immunohistochemical data. RT-PCR revealed PGDS gene expression in all meningiomas studied, regardless of histological subtypes, and also in human arachnoid villi. Because human arachnoid and meningioma cells exclusively express PGDS, it can be considered their specific cell marker. These results show functional differences in various types of meningeal cells attributable to differences in PGDS expression.
Porous SiOCH Integration: Etch Challenges with a Trench First Metal Hard Mask Approach (2011)

The use of a metallic hard mask approach for porous dielectric film integration implies for patterning processes, different difficulties like dimensional control, bottom line roughness and residue formation or chamber conditioning. In this paper we propose to present these issues and associated solutions for p-SiOCH integration in dual damascene structure using a trench first metallic hard mask approach.
Effect of acute and chronic administration of clonidine on hypothalamic content of growth hormone-releasing hormone and somatostatin in the rat (1991)

Hypothalamic GH-releasing hormone (GHRH) and somatostatin contents were determined in male rats at pre- and mid-pubertal stages following acute (0.15 mg/kg) or chronic (0.1 mg/kg twice daily for 7 days) administration of clonidine. Hypothalamic GHRH content increased markedly during transition from pre- to mid- and late-pubertal stages (2.05 +/- 0.17 vs 3.13 +/- 0.26 and 3.46 +/- 0.20 ng/hypothalamus respectively, means +/- S.E.M.). Hypothalamic GHRH content was markedly decreased 1 h after clonidine administration in mid-pubertal but not in prepubertal rats (3.67 +/- 0.23 vs 2.65 +/- 0.22 ng/hypothalamus). Hypothalamic somatostatin content, on the other hand, decreased in both age groups, although the decrease in the mid-pubertal group was more pronounced (51% and 38% respectively). In addition, the GH responsiveness to clonidine was higher at mid-puberty than at prepuberty. Determination of hypothalamic somatostatin and GHRH content in the chronic experiment 4 h after the last drug administration revealed a marked decrease in GHRH in the mid-pubertal rats and a slight decrease in the prepubertal rats (1.78 +/- 0.32 vs 3.15 +/- 0.31 and 2.01 +/- 0.30 vs 2.35 +/- 0.15 ng/hypothalamus; P less than 0.005 and P less than 0.05 respectively) whereas somatostatin levels were not altered. It is suggested that the clonidine-induced GH secretion is modulated by a chain of events which involves primary stimulation of GHRH release resulting in increased GH secretion which, via a negative-feedback mechanism, triggers an enhancement of somatostatin release which ultimately normalizes the system. This mechanism is age-dependent and reaches full maturity only at the onset of puberty.
Submicrometer Particle Formation and Mercury Speciation Under O2−CO2 Coal Combustion (2006)

The characteristics of the submicrometer mode of ash and mercury speciation on combustion of coal in an oxygen−carbon dioxide and air (conventional) system were compared. The experiments were conducted at different O2:CO2 and O2:N2:CO2 mixing ratios. On replacing the nitrogen in air with carbon dioxide, the total mass of the particles in the submicrometer mode (<0.5 μm) of ash was smaller. Correspondingly, the geometric mean size (dpg) of the submicrometer aerosol was smaller by approximately 28%. When the O2:CO2 ratio was increased from 1:4 to 4:4, the geometric mean size of the submicrometer mode increased from 29 to 54 nm because of a faster vaporization rate as a result of a higher coal particle temperature. An increase in the geometric mean size was observed on increasing the N2:CO2 ratio at a fixed O2 concentration because of the same reasons. The shape of the primary particles was spherical in all the tests, indicating that a vapor to particle transformation pathway was prevalent. The ratios of elemental to oxidized mercury (approximately 4:1) were similar for O2−CO2 and air combustion.
An enzymatic activation of formaldehyde for nucleotide methylation (2021)

Folate enzyme cofactors and their derivatives have the unique ability to provide a single carbon unit at different oxidation levels for the de novo synthesis of amino-acids, purines, or thymidylate, an essential DNA nucleotide. How these cofactors mediate methylene transfer is not fully settled yet, particularly with regard to how the methylene is transferred to the methylene acceptor. Here, we uncovered that the bacterial thymidylate synthase ThyX, which relies on both folate and flavin for activity, can also use a formaldehyde-shunt to directly synthesize thymidylate. Combining biochemical, spectroscopic and anaerobic crystallographic analyses, we showed that formaldehyde reacts with the reduced flavin coenzyme to form a carbinolamine intermediate used by ThyX for dUMP methylation. The crystallographic structure of this intermediate reveals how ThyX activates formaldehyde and uses it, with the assistance of active site residues, to methylate dUMP. Our results reveal that carbinolamine species promote methylene transfer and suggest that the use of a CH<sub>2</sub>O-shunt may be relevant in several other important folate-dependent reactions.
A Base-Station Antenna Array Receiver with Interference Cancellation for Wideband CDMA (1999)

This paper is concerned with a combining technique of adaptive array antenna and multiple access interference (MAI) cancellation to increase system capacity in wideband code division multiple access (W-CDMA) systems. With fading vector channels and base stations using coherent demodulation, the performance of the proposed combining multi- user detector is analyzed through several simulations and the effects of power and cross-correlation thresholds of interfering signals are also analyzed. The experimental results show that the combining array antenna system achieves improvement in overall system capacity with reduced system complexity.
Changes in the proteomics of exhaled breath condensate under the influence of inhaled hydrogen in patients with post-COVID syndrome (2023)

Aim . To study the effect of inhalation therapy with an active hydrogen (AH) on the protein composition of exhaled breath condensate (EBC) in patients with post-COVID syndrome (PCS). Material and methods . This randomized controlled parallel prospective study included 60 patients after coronavirus disease 2019 (COVID-19) with PCS during the recovery period and clinical manifestations of chronic fatigue syndrome who received standard therapy according to the protocol for managing patients with chronic fatigue syndrome (CFS). The patients were divided into 2 groups: group 1 (main) — 30 people who received standard therapy and AH inhalations (SUISONIA, Japan) for 10 days, and group 2 (control) — 30 medical workers who received only standard therapy. Patients in both groups were comparable in sex and mean age. All participants in the study were sampled with EBC on days 1 and 10. Samples were subjected to tryptic digestion and high-performance liquid chromatography combined with tandem mass spectrometry analysis using a nanoflow chromatograph (Dionex 3000) in tandem with a high-resolution time-of-flight mass spectrometer (timsTOF Pro). Results . A total of 478 proteins and 1350 peptides were identified using high resolution mass spectrometry. The number of proteins in samples after AH therapy, on average, is 12% more than before treatment. An analysis of the distribution of proteins in different groups of patients showed that only half of these proteins (112) are common for all groups of samples and are detected in EBC before, after, and regardless of hydrogen therapy. In addition to the qualitative difference in the EBC protein compositions in different groups, quantitative changes in the concentration of 36 proteins (mainly structural and protective) were also revealed, which together made it possible to reliably distinguish between subgroups before and after treatment. It is worth noting that among these proteins there are participants of blood coagulation (а-1-antitrypsin), chemokine- and cytokine-mediated inflammation, and a number of signaling pathways (cytoplasmic actin 2), response to oxidative stress (thioredoxin), glycolysis (glyceraldehyde-3- phosphate dehydrogenase), etc. Conclusion . The use of hydrogen therapy can contribute to the switching of a number of physiological processes, which may affect the success of recovery in PCS patients. In particular, the obtained results indicate the activation of aerobic synthesis of adenosine triphosphate in mitochondria by hydrogen therapy, which correlates well with the decrease in the blood lactate level detected by laboratory studies. At the same time, this therapy can inhibit pro-inflammatory activity, negatively affecting the coagulation and signaling pathways of integrins and apoptosis, and, in addition, activate protective pathways, tricarboxylic acid cycle, FAS signaling, and purine metabolism, which may be essential for effective recovery after COVID-19.
Elastic full waveform Inversion for land walkaway VSP data (2014)

Summary Full waveform inversion (FWI) is capable of handling multicomponent borehole seismic data and reveals quantitative values of the subsurface medium properties, including compressional and shearwave velocities. Careful treatment of the source wavelet is crucial for FWI and is a challenging task for land data due to drastic variations of the near-surface conditions. We present a feasibility study of anisotropic elastic FWI for land walkaway vertical seismic profiling (VSP) data acquired in northeast British Columbia, Canada, with a vibrator source. FWI explained the data at medium frequencies and recovered a layered structure of the subsurface that agrees to reasonable accuracy with sonic measurements. The source signature inversion compensated the variation of the near-surface conditions for different offsets.
Multi-scale approach for the electromagnetic modeling of metallic FSS grids of finite thickness with non-uniform cells (2009)

In this communication, the Scale Changing Technique is used for the global electromagnetic simulation of frequency selective surfaces consisting of non-uniform rectangular waveguides perforating a thick metallic plate. Excellent agreement between the Scale Changing Technique and the Finite Element Method is observed with substantial reduction in computation time and memory when using the proposed technique, which may be compatible with an optimization process.
Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy (2008)

Polypoidal lesions of PCV are treatable with PDT; however, they often recur. The branching vascular networks do not regress and allow the recurrence of polypoidal lesions at the network termini. Alterations of the vascular features may occur; careful observation is needed after PDT.
A comprehensive study of monolithic 3D cell on cell design using commercial 2D tool (2015)

In this paper we present a methodology allowing an emulated-3D two tiers physical implementation of any design using 2D commercial tools. Place and Route is achieved through similar steps as required by 2D designs: pre clock tree synthesis (including placement), clock tree synthesis and routing; to which we added a folding step in order to emulate the 3D placement. Routing of both tiers in parallel using inter-tier metal layers is made possible by modifying input files of the tools. Our study covers power supply network on both tiers, forbidden inter-tier via on active placement and inter-tier back end flavors in order to refine quality of results. Benchmark results on two tiers 3D Monolithic integration have been done on several IPs (microcontroller, reconfigurable FFT and LDPC) using as reference ST 28nm FDSOI technology and show the correlation between cell density, routing congestion, wire length, operating frequency and power consumption. To our knowledge, this paper is the first one to evaluate monolithic 3D physical implementation using full 3D Back End description and taking into account power supply distribution on both tiers.
Odor Mitigation from Lime Stabilized Biosolids (2001)

Odor Mitigation from Lime Stabilized BiosolidsSeveral studies were conducted to evaluate odors from biosolids that arise from upstream processes and from storage. One study that evaluated biosolids odors originating from upstream processes demonstrated that wastewater solids that was odorous prior to stabilization (such as from back-ups during processing), would remain odorous after stabilization. The biosolids odors produced during high...Author(s)Sudhir N. MurthyThomas SadickWalter BaileyChris PeotMary StrawnSourceProceedings of the Water Environment FederationSubjectSession 10: Odor Control Issues and AnswersDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2001ISSN1938-6478SICI1938-6478(20010101)2001:1L.725;1-DOI10.2175/193864701784993056Volume / Issue2001 / 1Content sourceResiduals and Biosolids ConferenceFirst / last page(s)725 - 736Copyright2001Word count276
Development of a Unique Heterogeneous Palladium Catalyst for the Suzuki–Miyaura Reaction using (Hetero)aryl Chlorides and Chemoselective Hydrogenation (2017)

Abstract A unique heterogeneous palladium catalyst (7% Pd/WA30) supported on an anion exchange resin, which contains N , N ‐dimethylaminoalkyl functionalities on the polymer backbone, was developed. 7% Pd/WA30 could smoothly catalyze Suzuki–Miyaura reactions of even less reactive heteroaryl chlorides and heteroarylboronic acids to afford various (hetero)biaryls due to the electron‐donating effect of the tert ‐amines on WA30 to Pd species. It was also applicable as a chemoselective hydrogenation catalyst, showing inactivity for the hydrogenolysis of tert ‐butyldimethylsilyl (TBS) ethers, alkyl benzyl ethers, and benzyl alcohols. The tert ‐amines on WA30 acted as moderate catalyst poisons for Pd, resulting in chemoselective hydrogenation. 7% Pd/WA30 was reused for at least five times without any loss of the hydrogenation catalytic activity. magnified image
The in Vitro Structure-Related Anti-Cancer Activity of Ginsenosides and Their Derivatives (2011)

Panax ginseng has long been used in Asia as a herbal medicine for the prevention and treatment of various diseases, including cancer. The current study evaluated the cytotoxic potency against a variety of cancer cells by using ginseng ethanol extracts (RSE), protopanaxadiol (PPD)-type, protopanaxatriol (PPT)-type ginsenosides fractions, and their hydrolysates, which were prepared by stepwise hydrolysis of the sugar moieties of the ginsenosides. The results showed that the cytotoxic potency of the hydrolysates of RSE and total PPD-type or PPT-type ginsenoside fractions was much stronger than the original RSE and ginsenosides; especially the hydrolysate of PPD-type ginsenoside fractions. Subsequently, two derivatives of protopanaxadiol (1), compounds 2 and 3, were synthesized via hydrogenation and dehydration reactions of compound 1. Using those two derivatives and the original ginsenosides, a comparative study on various cancer cell lines was conducted; the results demonstrated that the cytotoxic potency was generally in the descending order of compound 3 > 20(S)-dihydroprotopanaxadiol (2) > PPD (1) > 20(S)-Rh2 > 20(R)-Rh2 ≈ 20(R)-Rg3 ≈ 20(S)-Rg3. The results clearly indicate the structure-related activities in which the compound with less polar chemical structures possesses higher cytotoxic activity towards cancer cells.
On slot allocation for time-constrained messages in DQDB networks (2002)

The paper addresses the issue of guaranteeing the timely delivery of isochronous messages with hard deadlines in a distributed queue dual bus (DQDB) network. The authors propose a slot allocation scheme which can allocate bandwidth for a set of isochronous message streams and provide deterministic deadline guarantees. The allocation scheme is guaranteed to find a feasible slot allocation (in the sense that all messages can be transmitted in a timely manner) as long as the total message density is less than or equal to a certain threshold, where the total message density is defined as the summation (over all message streams) of the ratio of maximum message size to message deadline. The implementation of this scheme is simple and does not require any change of the current DQDB standard.
Detection of EGFR Mutations by TaqMan Mutation Detection Assays Powered by Competitive Allele-Specific TaqMan PCR Technology (2013)

Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) are predictive of response to treatment with tyrosine kinase inhibitors. Competitive Allele-Specific TaqMan PCR (castPCR) is a highly sensitive and specific technology. EGFR mutations were assessed by TaqMan Mutation Detection Assays (TMDA) based on castPCR technology in 64 tumor samples: a training set of 30 NSCLC and 6 colorectal carcinoma (CRC) samples and a validation set of 28 NSCLC cases. The sensitivity and specificity of this method were compared with routine diagnostic techniques including direct sequencing and the EGFR Therascreen RGQ kit. Analysis of the training set allowed the identification of the threshold value for data analysis (0.2); the maximum cycle threshold (Ct = 37); and the cut-off ΔCt value (7) for the EGFR TMDA. By using these parameters, castPCR technology identified both training and validation set EGFR mutations with similar frequency as compared with the Therascreen kit. Sequencing detected rare mutations that are not identified by either castPCR or Therascreen, but in samples with low tumor cell content it failed to detect common mutations that were revealed by real-time PCR based methods. In conclusion, our data suggest that castPCR is highly sensitive and specific to detect EGFR mutations in NSCLC clinical samples.