gebhart/patrepeval huggingface dataset:
Faculty Opinions recommendation of The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. (2006)

c-FLIP proteins (isoforms: c-FLIP L , c-FLIP S , and c-FLIP R ) play an essential role in the regulation of death receptor-induced apoptosis. Here, we demonstrate that the cytoplasmic NH 2 -terminal procaspase-8 cleavage product of c-FLIP (p22-FLIP) found in nonapoptotic malignant cells, primary T and B cells, and mature dendritic cells (DCs) strongly induces nuclear factor B (NF-B) activity by interacting with the IB kinase (IKK) complex via the IKK subunit. Thus, in addition to inhibiting apoptosis by binding to the death-inducing signaling complex, our data demonstrate a novel mechanism by which c-FLIP controls NF-B activation and life/death decisions in lymphocytes and DCs.
An Ultrahigh Output Rechargeable Electrode of a Hydrophilic Radical Polymer/Nanocarbon Hybrid with an Exceptionally Large Current Density beyond 1 A cm−2 (2018)

Facile charge transport by a hydrophilic organic radical-substituted polymer and the 3D current collection by a self-assembled mesh of single-walled carbon nanotube bundles lead to the operation of an ultrahigh-output rechargeable electrode. Exceptionally large current density beyond 1 A cm<sup>-2</sup> and high areal capacity around 3 mAh cm<sup>-2</sup> are achieved, which are 10<sup>1-2</sup> times larger than those of the previously reported so-called "ultrafast electrodes." A sub-millimeter-thick, flexible, highly safe organic redox polymer-based rechargeable device with an aqueous sodium chloride electrolyte is fabricated to demonstrate the superior performance.
Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study (1996)

In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hopkins University sample of 46-52 informative pedigrees for chromosomes 3 and 8, and the Medical College of Virginia sample of 156-191 informative pedigrees for chromosome 6). Primary planned analyses (New sample) were two-point heterogeneity lod score (lod2) tests (dominant and recessive affected-only models), and multipoint affected sibling pair (ASP) analysis, with a narrow diagnostic model (DSM-IIIR schizophrenia and schizoaffective disorders). Regions with positive results were also analyzed in the Original and Combined samples. There was no evidence for linkage on chromosome 3. For chromosome 6, ASP maximum lod scores (MLS) were 2.19 (New sample, nominal p = 0.001) and 2.68 (Combined sample, p = .0004). For chromosome 8, maximum lod2 scores (tests of linkage with heterogeneity) were 2.22 (New sample, p = .0014) and 3.06 (Combined sample, p = .00018). Results are interpreted as inconclusive but suggestive of linkage in the latter two regions. We discuss possible reasons for failing to achieve a conclusive result in this large sample. Design issues and limitations of this type of collaborative study are discussed, and it is concluded that multicenter follow-up linkage studies of complex disorders can help to direct research efforts toward promising regions.
Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance (2008)

Fine needle aspiration biopsy (FNAB) is a rapid and cost-effective method for obtaining a first-line diagnosis of a palpable mass of the breast. However, because it can be difficult to manually discriminate between adipose tissue and the fibroglandular tissue more likely to harbor disease, this technique is plagued by a high number of nondiagnostic tissue draws. We have developed a portable, low coherence interferometry (LCI) instrument for FNAB guidance to combat this problem. The device contains an optical fiber probe inserted within the bore of the fine gauge needle and is capable of obtaining tissue structural information with a spatial resolution of 10 mum over a depth of approximately 1.0 mm. For such a device to be effective clinically, algorithms that use the LCI data must be developed for classifying different tissue types. We present an automated algorithm for differentiating adipose tissue from fibroglandular human breast tissue based on three parameters computed from the LCI signal (slope, standard deviation, spatial frequency content). A total of 260 breast tissue samples from 58 patients were collected from excised surgical specimens. A training set (N=72) was used to extract parameters for each tissue type and the parameters were fit to a multivariate normal density. The model was applied to a validation set (N=86) using likelihood ratios to classify groups. The overall accuracy of the model was 91.9% (84.0 to 96.7) with 98.1% (89.7 to 99.9) sensitivity and 82.4% (65.5 to 93.2) specificity where the numbers in parentheses represent the 95% confidence intervals. These results suggest that LCI can be used to determine tissue type and guide FNAB of the breast.
Perioperative heart failure in coronary surgery and timing of intra‐aortic balloon pump insertion (2010)

Postponing the use of IABP may be deleterious in patients with drug-refractory HF. In the presence of the three factors independently associated with the risk of a drug-refractory HF, early IABP insertion is suggested.
Proposal of Knowledge Graph and Completion Method for Solving Social Issues: An Attempt to Improve the Bicycle Parking Environment in the University (2020)

Societies in Japan face many social issues today. To address these issues, the government is exploring ways to solve problems using data. The purpose of this study is to provide support using existing data for grasping the current situation, taking up the problem of bicycle parking environment in a university as an example of social issues. Specifically, we tried to design a unique schema and build knowledge graph for integration of various on-campus data. Then we applied and modified the knowledge graph completion methods to improve efficiency and accuracy. For the knowledge graph constructed in this study, the number of bicycles was estimated by the conventional method and the proposed method, and the transition of the sum of absolute value errors was compared. The proposed method exceeded the existing method in efficiency and accuracy. In addition, approximately 650 data aggregated at any date and place were able to be estimated about 54 units correctly, compared to the conventional method. Finally, we improved efficiency and accuracy of knowledge graph completion methods.
Helical Ferrite Devices for Non-Reciprocal Applications (2009)

This paper introduces the use of Viscous Plastic Processing (VPP) for the production of microwave ferrite materials and components. Conventional ceramic processing methods produce bulk ferrite materials restricted to relatively simple shapes and that can possess significant micro-structural defects resulting in poor mechanical properties. Using VPP the microstructures and physical strength of ferrite materials can be substantially enhanced and entirely new and unique device geometries produced, such as those based on ferrite helices. Ferrite Materials produced by VPP, such as lithium based ferrites, will be compared to those produced by standard methods of production such as powder pressing.
Wood stoves and their installation (1978)

"Literally dozens of kinds of wood burning stoves are available; many have been on the market for less than five years. Most can be described by one of the following general categories."--First page.
Abstract 14058: Transvascular Total Left Ventricular Unloading for Acute Myocardial Infarction Strikingly Reduced Myocardial Oxygen Consumption, Limited the Infarct Size and Prevented Heart Failure in the long term (2015)

Backgrounds: Despite the latest progresses of early reperfusion, myocardial infarction (MI) remains a leading cause of chronic heart failure (CHF). Left ventricular (LV) assist device (VAD) mechanically unloads LV, thus myocardial oxygen consumption (MVO2). Theoretical analysis indicates that the partial VAD (p-VAD) where LV remains ejecting decreases preload (EDV) while increases afterload (ESV), thereby marginally decreases MVO2. In contrast, total LVAD (t-VAD) where LV no longer ejects, markedly decreases ESV as well as EDV, thus markedly reduces MVO2. We examined whether t-VAD in ischemia reperfusion (IR) could reduce the infarct size and prevent heart failure in the long term. Methods: First, in normal dogs, we examined the impact of p-VAD and t-VAD on MVO2 by Fick principle (coronary flow and arterial venous O2 difference). Second, we occluded the left anterior descending coronary artery for 3 hours and reperfused. We started transvascular LVAD (Impella®) from 1 hour after ischemia to 1 hour after reperfusion. We compared cardiac function, infarct size and hormones 1 month after ischemia among 3 groups, control group (IR, n=8), p-VAD (n=6), and t-VAD (n=6). Results: t-VAD markedly decreased MVO2 (p&lt;0.05, Figure 1). 1 month after ischemia, t-VAD normalized LV end-systolic elastance (IR: 6.5±3.2, p-VAD: 9.7±1.3, t-VAD: 12.8±5.1 mmHg/ml, p&lt;0.05) and reduced LV end-diastolic pressure (16.5±2.7, 6.4±2.9, 4.4±1.5 mmHg, p&lt;0.05), and NT proBNP (3391±1364, 2084±348, 1632±228 pg/ml, p&lt;0.05) indicating the successful prevention of heart failure. t-VAD markedly reduced the infarct size by more than 80% relative to IR (p&lt;0.05, Figure 2) despite the fact that it started 1 hour after the onset of ischemia. Conclusions: Transvascular total left ventricular unloading for acute myocardial infarction strikingly reduces the MI size and prevents heart failure in the chronic phase. It might serve as a new therapeutic strategy in the management of patients with acute MI.
Estimation of deviations between stylus position and CMM scales indication in high speed probing (1997)

The Coordinale Measuring Machine(CMM) is a nexihle an&amp;lt;.lu~erullllachineror a lot or Illea~uring lasks. But il is nol used rol &amp;apos; rneasuring alJ (he mechanical parts in manufacluring Iines. beeau.se Ihis lakes [00 much lime. In order la re&amp;lt;.luce time 10 mcasure, it is importanI 10 increasc Ihe velocily in probing. However, the devialions bel ween Ihe posilioll or Ihe slylus and Ihe posilion measured by lhe linear scales of lhe CMM becollle largel &amp;apos; in high speed prohing by bending of hearns and rolalions amund axis due 10 lhe accelcralion ron;es. These devialions hecomc (hen all imporlanl mea~;uring error. Therefnre. in mder 10 reuucc these devialions, we analysed Ihe devialions when the CMM X-Guideway moved along Ihe direclion of Ihe y-axis and found arelalion bel ween lhe devialion.s, Ihe vc!ocily ana the accc!eralion. Finally wc have cOlllpensaled lhese devialions numerically wilh lhe reading or Ihe lillenr scales or Ihis CMM. Key wnrds: high speed prohing, conrdinale measuring machine. dynamic hehavior. calihration, hending, rolation
Cationic α-Diimine Nickel and Palladium Complexes Incorporating Phenanthrene Substituents: Highly Active Ethylene Polymerization Catalysts and Mechanistic Studies of syn/anti Isomerization (2020)

α-Diimine palladium complexes incorporating phenanthryl- and 6,7-dimethylphenanthrylimino groups have been synthesized and characterized. The (diimine)PdMeCl complexes prepared from 2,3-butanedione and acenaphthenequinone bearing the unsubstituted phenanthrylimino groups, 12a and 14a, respectively, exist as a mixtures of syn and anti isomers in a ca. 1:1 ratio. Separation and X-ray diffraction analysis of 14a-syn and 14a-anti isomers confirms the syn/anti assignments. The barrier to interconversion of 14a-syn and 14a-anti via ligand rotation, ΔG⧧, was found to be 25.5 kcal/mol. The corresponding (diimine)PdMeCl complex prepared from acenaphthenequinone and incorporating the 6,7-dimethylphenanthrylimino group exists solely as the anti isomer, 14b, due to steric crowding which destabilizes the syn isomer. Analogous (diimine)NiBr2 complexes were prepared from 2,3-butanedione incorporating the phenanthrylimino group, 16a, and the 6,7-dimethylphenanthrylimino group, 16b. Nickel-catalyzed polymerizations of ethylene were carried out by activation of the dibromide complexes 16a,b using various aluminum alkyl activators. Complex 16a yields a bimodal distribution polymer, the low-molecular-weight fraction originating from the syn isomer and the high-molecular-weight fraction arising from the anti isomer. Polymerizations carried out by 16b yield only high-molecular-weight polymers with monomodal distributions due to the existence of a single isomer (anti) as the active catalyst. All polymers are linear or nearly so. All catalysts are highly active, but catalysts derived from 16b are somewhat more active than 16a and exhibit turnover frequencies generally over 106 and up to 5 × 106 per hour (40 °C, 27.2 atm ethylene, 15 min). Active palladium ethylene oligomerization catalysts were generated by conversion of the neutral methyl chloride complexes 14a,b to the cationic nitrile complexes 15a,b via halide abstraction.
Immunohistochemical characterization of a 183 KD myeloid-specific-DNA- binding protein in B5 fixed, paraffin-embedded tissues, and bone marrow aspirates by monoclonal antibody BM-1 (1987)

A monoclonal antibody, designated BM-1, which is reactive in B5 formalin-fixed, paraffin-embedded tissues, has been generated against a cytoplasmic and nuclear antigen expressed in human myeloid precursor cells and derived leukemias. Using the avidin-biotin-complex immunoperoxidase procedure, BM-1 was found to stain selectively myeloid precursor cells in normal bone marrow and mature granulocytes in the blood. In a screen of 26 normal adult and fetal human organs fixed in B5 formalin, BM-1 was negative in all nonhematopoietic tissues with the exception of tissue granulocytes and scattered cells in the peripheral cortex of the thymus. Likewise a screen of 30 solid tumor cell lines including a spectrum of carcinomas, sarcomas, and neural-derived tumors was negative. BM-1 was also negative with 21 T and B cell lymphomas and 11 Hodgkin's disease tumors. A preliminary study of tumors of the hematopoietic system revealed that BM-1 was reactive with M2 and M3 acute myelogenous leukemias (AML), chronic myelogenous leukemias (CML) and myelomonocytic leukemias, and granulocytic sarcomas. M1, M4, M5, and M6 AML clot preparations were negative in this study, indicating that BM-1 may have a role in the histopathologic diagnosis of myelogenous leukemia. Myeloid leukemic cell lines HL-60, ML-2, KG1, and TPH-1-O showed BM-1 nuclear and/or cytoplasmic reactivity in a subpopulation of cells, but erythroid and lymphoid leukemias and all lymphoma cell lines were negative. Immunoperoxidase studies of a panel of fetal tissues showed BM-1 positive cells in the peripheral cortex of the thymus and portal myelopoietic regions of the liver at 18 weeks gestation. Finally, DNA-cellulose and solid phase radioimmunoassay (RIA) techniques developed in our laboratory demonstrate that the BM-1 antigenic domain is reactive only after binding to eukaryotic but not prokaryotic single- or double-stranded DNA. Immunoblot techniques using a DNA-cellulose purified protein sample revealed that BM-1 recognizes a 183 kD protein. These studies indicate that BM-1 is recognizing a myeloid-specific antigen that, because of its DNA binding characteristics, may have an important role in the differentiation of myeloid cells at the molecular level.
Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation (2018)

Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. We aimed to identify and validate methylated DNA markers (MDMs) for HCC detection. Reduced representation bisulfite sequencing was performed on DNA extracted from 18 HCC and 35 control tissues. Candidate MDMs were confirmed by quantitative methylation-specific PCR in DNA from independent tissues (74 HCC, 29 controls). A phase I plasma pilot incorporated quantitative allele-specific real-time target and signal amplification assays on independent plasma-extracted DNA from 21 HCC cases and 30 controls with cirrhosis. A phase II plasma study was then performed in 95 HCC cases, 51 controls with cirrhosis, and 98 healthy controls using target enrichment long-probe quantitative amplified signal (TELQAS) assays. Recursive partitioning identified best MDM combinations. The entire MDM panel was statistically cross-validated by randomly splitting the data 2:1 for training and testing. Random forest (rForest) regression models performed on the training set predicted disease status in the testing set; median areas under the receiver operating characteristics curve (AUCs; and 95% confidence interval [CI]) were reported after 500 iterations. In phase II, a six-marker MDM panel (homeobox A1 [HOXA1], empty spiracles homeobox 1 [EMX1], AK055957, endothelin-converting enzyme 1 [ECE1], phosphofructokinase [PFKP], and C-type lectin domain containing 11A [CLEC11A]) normalized by beta-1,3-galactosyltransferase 6 (B3GALT6) level yielded a best-fit AUC of 0.96 (95% CI, 0.93-0.99) with HCC sensitivity of 95% (88%-98%) at specificity of 92% (86%-96%). The panel detected 3 of 4 (75%) stage 0, 39 of 42 (93%) stage A, 13 of 14 (93%) stage B, 28 of 28 (100%) stage C, and 7 of 7 (100%) stage D HCCs. The AUC value for alpha-fetoprotein (AFP) was 0.80 (0.74-0.87) compared to 0.94 (0.9-0.97) for the cross-validated MDM panel (P < 0.0001). Conclusion: MDMs identified in this study proved to accurately detect HCC by plasma testing. Further optimization and clinical testing of this promising approach are indicated.
Improvement of laser-induced damage threshold in CZ-BBO by reducing the light scattering center with annealing (1998)

The laser-induced damage threshold in β -BaB2O4 grown by Czochralski method ( CZ-BBO ) is improved by annealing at 920 °C to reduce the intensity of scattered light in the crystal. Experiments indicate that the reduction is generated as a result of dipole radiation vibrated along the z-axis. The threshold in 266 nm of annealed CZ-BBO is improved to 3.4 GW/cm2, which is 1.70 times higher than that of as-grown CZ-BBO and 1.13 times higher than that of as-grown Flux-BBO.
Polymer-metal organic framework materials and methods of using the same (2023)

Disclosed herein, inter alia, are polymerized metal organic framework compositions and polymer compositions, and methods of making and using the same.
Supplementary Figures from Efficacy of a Cancer Vaccine against <i>ALK</i>-Rearranged Lung Tumors (2023)

&lt;p&gt;Supplementary Figure S1. ALK Tg mice develop lung multifocal adenocarcinomas similar to human ALK-rearranged NSCLC. Supplementary Figure S2. Therapeutic ALK vaccine impairs tumor growth of ALK-rearranged lung tumors. Supplementary Figure S3. Immunophenotype of EML4-ALK transgenic mice Supplementary Figure S4. Human ALK-rearranged NSCLC show a pattern of low expression of T cell markers. Supplementary Figure S5. PD-L1 expression is dependent on ALK kinase activity in ALK-rearranged NSCLC cells. Supplementary Figure S6. Schematic protocols of the in vivo treatment with anti-PD-1 blocking antibody. Supplementary Figure S7. ALK vaccine can be combined with ALK inhibitor TAE684. Supplementary Figure S8. Immunophenotype of intratumoral T cells in ALK vaccinated mice.&lt;/p&gt;
Monitoring boiling histotripsy with bubble-based ultrasound techniques (2014)

Cavitation phenomena have been always considered as a predominant mechanism of concern in mechanical tissue damage induced by therapeutic ultrasound. Corresponding methods have been developed to monitor cavitation. Recently, a new high intensity focused ultrasound technology, called boiling histotripsy (BH), was introduced, in which the major physical phenomenon that initiates mechanical tissue damage is vapor bubble growth associated with rapid tissue heating to boiling temperatures. Caused by nonlinear propagation effects and the development of high-amplitude shocks, this tissue heating is localized in space and can lead to boiling within milliseconds. Once a boiling bubble is created, interaction of shock waves with the cavity results in tissue disintegration. While the incident shocks can lead to cavitation phenomena and accompanying broadband emissions, the presence of a millimeter-sized vapor cavity in tissue produces strong echogenicity in ultrasound (US) imaging that can be exploited with B-mode diagnostic ultrasound. Various other methods of imaging boiling histotripsy, including passive cavitation detection (PCD), Doppler or nonlinear pulse-inversion techniques, and high speed photography in transparent gel phantoms are also overviewed. The role of shock amplitude as a metric for mechanical tissue damage is discussed. [Work supported by NIH EB007643, T32DK007779, and NSBRI through NASA NCC 9-58.]
Multi variable control of filamentation of femtosecond laser pulses propagating in air (2015)

A comprehensive approach for control of filamentation and generation of a high density conductive channel during femtosecond intense laser pulse propagation in air is being reviewed. Imposing astigmatism on the beam with a tilted lens allows obtaining a single stable filament out of a high power pulse (orders of magnitude higher than the critical power), which would otherwise generate random multiple filamentation pattern. The collapse distance of filaments is controlled with a double lens setup. Once the filament is stabilized, a substantially extended lifetime of the high density plasma channel generated in its wake is experimentally demonstrated using combination of femtosecond and nanosecond laser pulses. Free electron density above 1015 cm−3 in the formed plasma filament is measured to sustain for over 30 ns. This high density plasma lifetime prolongation of more than one order of magnitude is achieved by properly timed irradiation of the filament with a relatively low intensity nanosecond laser pulse, in comparison to a filament without such irradiation. The experimental results are in good agreement with our theoretical model that follows the evolution of the temperature and density of various molecules, atoms and ion species. The results point to the possibility of generating substantially long time duration, stable high density plasma filaments in air.
Cytometry microchip using polymer-based saltbridge electrodes (2005)

We developed a cytometry glass chip using polymer-based saltbridge electrodes. Saltbridge electrodes were placed at lateral sides of channel to increase the sensitivity and robustness of detection. The dimension of saltbridge electrodes which are exposed to channel was 50mum by 20mum (width, height). The saltbridge electrode was formed at a specific position in a predefined shape by photopolymerization technique. UV light sensitive monomer DMAC (dially dimethyl ammonium chloride) was used for polymerization. Polymer-based saltbridge electrode enabled the DC impedance analysis of the channel for cytometry. Moreover, the lateral positioning of saltbridge electrode is easily accomplished by photopolymerization technique. We validated the detection sensitivity of developed chip using 10mum fluorescent bead.
Characterizing local dose perturbations due to gas cavities in magnetic resonance‐guided radiotherapy (2020)

We show that local dose perturbations around unplanned spherical air cavities during MRgRT can be well characterized analytically. We present an equation that can be incorporated into the clinical workflow to allow for fast evaluation of dose effects of unplanned gas. We also envision this method contributing to the clinical implementation of real time adaptive radiotherapy (ART) for MRgRT using MRI planning.