gebhart/patrepeval huggingface dataset:
Design Optimization and Experimental Verification of Centrifugal Compressors With Curvilinear Element Blades (2012)

This paper describes the optimal design and experimental verification of centrifugal compressors with leaned curvilinear element blades. The design targets were a fully shrouded centrifugal impeller and a low-solidity vaned diffuser. First, a new method of defining the curvilinear element blade was developed for centrifugal turbomachinery using coordinate transformations between a revolutionary flow-surface coordinate system and a cylindrical coordinate system. All the blade sections in the transferred cylindrical coordinate system were moved and stacked spanwise to form a new leaned blade surface. The inverse transformation results in a curvilinear element blade in the original coordinate system. The direction of movement of the blade section could be any of the existing definitions such as sweep, dihedral, or tangential lean. For simplicity, we have defined a “lean profile” as a general expression for the spanwise distribution profile of movement of the blade sections. Model compressors with curvilinear element blades were then designed at a suction flow coefficient of 0.073. Optimal lean profiles for the impeller and vaned diffuser that maximized adiabatic efficiency and uniformity of outflow were explored using a multi-objective genetic algorithm, Kriging surrogate model, and steady Reynolds-averaged Navier Stokes simulations. We chose efficiency-weighted solutions since the efficiency and uniformity had a positive correlation. A sensitivity analysis showed that tangential leans near the endwalls are keys for improving the impeller’s efficiency. The chosen optimal impeller had a concave blade suction surface and a concave leading edge. Although clear patterns in geometrical features for optimal diffuser vanes could not be captured, we found that the dihedral profile had a predominant effect on efficiency. The model compressors was experimentally measured and compared with traditional compressors as to their aerodynamic performance. The experimental apparatus was composed of a suction nozzle, impeller, diffuser, and return channel. The results demonstrated that the models’ adiabatic efficiency was higher by 1.2–1.4% at the design point. Although the stall margins slightly decreased (by 0.7%) in the experiments, the surge margins expanded (by 3.7–6.7%).
Manipulator motion control based on a robust acceleration controller (1992)

This paper proposes fast motion control of a robot manipulator based on a robust acceleration controller. This acceleration controller is constructed using a mixed sensitivity problem in H∞ control. The paper discusses the frequency performance taking sensor noise effects and disturbance rejection into account systematically. Moreover, this paper realizes a fast continuous path tracking control system based on the H∞ acceleration controller. This control system is constructed using only position information, and it makes the multi-degrees-of-freedom motion control system simpler.
ODP353 Sustained Suppression of IGF1 with AZP-3813, a Bicyclic 16-Amino Acid Peptide Antagonist of the Human Growth Hormone Receptor and a Potential New Treatment for Acromegaly (2022)

Abstract Medical treatment of acromegaly is based on either suppressing pituitary GH secretion or inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of IGF1. AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) with a KD of 1.9nM for the human GHR, and 18.5nM for the rat GHR. The circulating half-life of AZP-3813 in the rat is 11.2 hours. In previous studies, AZP-3813 was demonstrated to suppress IGF1 secretion in juvenile rats in a dose-related manner, and to maintain IGF1 suppression when given over 4 days. To examine the ability of chronic AZP-3813 treatment to maintain suppression of IGF1 levels, we injected normal, 5-week old (∼150g), male Sprague Dawley rats subcutaneously either with vehicle or with AZP-3813 at doses of either 10 or 30mg/kg QD for 19 days (n=7/group). Blood samples were collected immediately prior to either vehicle or AZP-3813 injection on days 1, 2, 3, 7, 10, 15 and 19, and 24h after the last injection (day 20). Samples were assayed for total IGF1 content by radioimmunoassay, and samples collected on days 2, 10 and 19 were also analyzed for AZP-3813 content by LC-MS/MS. At the initiation of treatment, the average body weight of the rats was 150.3 + 3.0g, and over the 20 days of the study animals treated with vehicle gained an average of 158.4 + 4.9g. In contrast, rats treated QD with 10 or 30mg/kg AZP-3813 gained 23.6 + 2.1 and 27.9 + 2.2% less weight than the vehicle-treated controls, respectively. Accumulation of AZP-3813 levels in the blood was observed with repeated daily injections of both 10 and 30mg/kg, increasing from day 2 levels by 107.1 + 12.5 and 125.2 + 36.3%, respectively, by day 19. In the vehicle-treated control rats, IGF1 levels increased from an initial 395.1 +16.3ng/ml to 674.4 + 19.8ng/ml by day 20. Twenty-four hours after the first injections of 10 and 30mg/kg AZP-3813, IGF1 levels were suppressed by 27.6 + 3.4 and 29.2 + 3.3%, respectively, versus vehicle-treated control levels, and, with continued treatment, a similar magnitude of IGF1 suppression was maintained through day 20 despite the progressively increasing levels of IGF1 observed in the vehicle-treated rats. At study termination on day 20, animals treated with 10 and 30mg/kg AZP-3813 were observed to have 4.1 and 4.6% shorter femur length, 1.1 and 3.6% shorter body length, and 7.7 and 13.3% less liver weight, respectively, as compared with vehicle-treated control rats. These results demonstrate that with continued treatment, the potent GHR antagonist activity exhibited by AZP-3813 translates to sustained in vivo suppression of IGF1 levels and associated parameters, and support its development as a potential therapy for acromegaly. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m., Monday, June 13, 2022 1:05 p.m. - 1:10 p.m.
True time-delay fiber-optic control of an ultrawideband array transmitter/receiver with multibeam capability (1995)

A true time-delay beamformer based on a fiber-optic dispersive prism is developed and characterized. The beamformer is used to control an ultrawideband time-steered array antenna, which is a significant improvement over inherently narrowband phased-array antennas. The time-steered transmitter antenna consists of eight broadband spiral elements in a sparsely-populated array. In transmit mode the bandwidth is microwave-component limited to 2-18 GHz. The transmitter shows an unprecedented performance with >100/spl deg/ azimuth steering and no observed squint over the full frequency range. We also extend the beamformer functionality and demonstrate, we believe for the first time, fully-independent dual-beam dual-frequency ultrawideband antenna transmitter operation. Furthermore, the beamformer is shown to be capable of controlling the transmitter under pulsed operation with microwave pulse-widths as short as 75 ps. In the phase-steered receive mode, the antenna is component-limited to two elements and a frequency range of 6-16 GHz. However, we can still demonstrate squint-free receiver steering over >70/spl deg/ azimuth over the full available frequency range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A board-level electro-microfluidic systems fabrication process based on electronic design methodology (2002)

Microfluidic/nanofluidic systems are a promising technology that will prove to be an essential tool in several research areas including but not limited to biotechnology. As microfluidic systems become more complex, the need for a more efficient design and implementation methodology becomes apparent. As such, this paper describes methodology that adapts Electronic Design Automation (EDA) tools to Fluidic Design Automation (FDA) that can be used to design and fabricate board-level electro-microfluidic and electro-nanofluidic systems comprised of a mix of fluidic and electronic layers.
Symbolwise MAP for Multiple Deletion Channels (2019)

We consider the problem of reconstructing a sequence from fixed number of deleted versions of itself (also called traces). The problem is motivated from recent developments in de novo DNA sequencing technologies. The main contribution of this work is to provide a polynomial time algorithm for symbolwise MAP decoding with multiple traces. The algorithm leverages a dynamic program on the edit graph. We also develop a heuristic with reduced time complexity using similar ideas and provide preliminary numerical evaluations.
HCVerso2: a phase III study of faldaprevir plus deleobuvir and ribavirin for chronic HCV genotype 1b infection in treatment naïve patients including those ineligible for pegylated interferon (2014)

peer reviewed
Fabrication of an integrated 670nm VCSEL-based sensor for miniaturized fluorescence sensing (2010)

Integrated optical semiconductor sensors are a promising technology for both lab-on-a-chip and molecular imaging applications due to their low cost, small size, high sensitivity, and flexible designs. We present the design and fabrication of a GaAs-based monolithically integrated fluorescence sensor incorporating 670nm VCSELs and PIN photodetectors. This is the first integrated, VCSEL-based fluorescence sensor with excitation at a far-red wavelength and is specifically designed for in vivo sensing applications. In addition, we discuss considerations to simultaneously achieve high power VCSELs and low dark current PIN photodetectors required for sensitive fluorescence detection. These fabricated sensors incorporate 670nm VCSELs emitting 2.0mW at room temperature (RT) with adjacent detectors exhibiting RT dark less than 2pA/mm<sup>2</sup> (100mV reverse bias). Fluorescence emission filters suitable for transmitting Cy5.5 fluorescent dye emission were integrated with the photodetectors. The sensor detects Cy5.5 molecules in vitro at 5nM concentration with linear response for concentrations up to 25&mu;M. These miniature sensors are suitable for portable diagnostic assays and in vivo rodent studies.
On-chip optical filter comprising Fabri-Perot resonator structure and spectrometer (2023)

An on-chip optical filter having Fabri-Perot resonators and a spectrometer may include a first sub-wavelength grating (SWG) reflecting layer and a second SWG reflecting layer facing each other. A plurality of Fabri-Perot resonators are formed by the first SWG reflecting layer and the second SWG reflecting layer facing each other. Each of the Fabri-Perot resonators may transmit light corresponding to a resonance wavelength of the Fabri-Perot resonator. The resonance wavelengths of the Fabri-Perot resonators may be determined according to duty cycles of grating patterns.
Antagonist binding sites of voltage-dependent calcium channels (1997)

Voltage-dependent calcium channels are crucial targets for a wide range of clinically active small organic pharmacological agents. These agents fall into several distinct classes of blockers, each associated with a unique site on the calcium channel α1 subunit. In addition, a number of peptide toxins isolated from invertebrates specifically bind to and block certain subtypes of voltage-dependent calcium channels. Voltage-dependent calcium channels are comprised of multiple subtypes, and not each of those subtypes are equally sensitive to small organic compounds and peptide blockers. Here, I present an overview of the classes of calcium channel blockers and our current understanding of their sites of action on the calcium channel protein. Drug Dev. Res. 42:131–143, 1997. © 1997 Wiley-Liss, Inc.
Metal complexes of a new bis(salicylidene) bicycle diamine ligand (1997)

The rigidity of cis-endo-2,3-diaminobicyclo[2.2.2]oct-5-ene (1) locks the nitrogens into spatial positions that are favorable to metal binding and should result in thermodynamically and kinetically more stable metal ligand complexes. Condensation of 1 and salicylaldehyde affords the N,N{prime}-bis(salicyclidene)-cis-endo-2,3-diamino-bicyclo[2.2.2]oct-5-ene (2) in high yield. X-ray diffraction of 2 shows that the nitrogens are cis and endo and that the phenolic hydrogens are hydrogen bonded to the nitrogens. The ligand 2 was found to form neutral complexes with divalent metals such as cobalt, nickel, and copper. X-ray crystal studies of the nickel complex (which contains one CHCl{sub 3} per Ni) showed a square planar arrangement of the coordinating groups around the metal. The nickel and the salicyclidene moieties roughly lie in the plane defined by carbons 2 and 3 and the two nitrogens.
RECOMMENDED PRACTICES FOR USE OF TRAFFIC BARRIER AND CONTROL TREATMENTS FOR RESTRICTED WORK ZONES (1994)

Many construction projects require the use of traffic barriers to adequately protect the motoring public and construction workers. Geometric and operational restrictions in these work zones frequently preclude the use of the same design standards for these barriers and terminals that normally apply to permanent systems. One common example involves two-lane, two-way bridges where one-half of the bridge is repaired while maintaining alternating one-way traffic in the remaining lane (usually with temporary traffic control signals). The most common method of traffic control is to install a concrete barrier on the bridge approaches and across the bridge to protect the motorists and workers. While this practice normally provides an acceptable measure of safety for motorists and workers, problems occur when an intersecting highway or driveway that cannot be closed exists near the end of the bridge. In this example, and in other restricted situations, there is often inadequate room to install either the barrier runout at the specified flare rate, an impact attenuator, or other terminal treatments meeting the performance standards for permanent barrier systems. The objective of this research was to develop improved end treatments for temporary traffic barriers, typical traffic control plans, and user guidelines for restricted work-zone situations. This project involved the identification of restricted work zone situations, the classification of specific situations into groups having similar traffic, site, geometric, and terrain characteristics, the development of conceptual designs for barrier terminal and traffic control treatments for each group, the evaluation of proposed treatments for typical situations considering safety, traffic capacity, user delay, costs, and ease of implementation, the development of detailed designs for barrier terminal treatments, crash testing of the terminal treatments, and the preparation of a user's manual for recommended barrier terminal treatments and special traffic control plans, and guidelines for their use. An informational video was also produced to help disseminate information about the problems of restricted work zones and to introduce the recommendations for improved traffic control treatments.
Mechanistic Studies of Antibody-Catalyzed Pyrimidine Dimer Photocleavage (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic Studies of Antibody-Catalyzed Pyrimidine Dimer PhotocleavageJohn R. Jacobsen, Andrea G. Cochran, James C. Stephans, David S. King, and Peter G. SchultzCite this: J. Am. Chem. Soc. 1995, 117, 20, 5453–5461Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ja00125a004https://doi.org/10.1021/ja00125a004research-articleACS PublicationsRequest reuse permissionsArticle Views743Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Nanoparticle Shape Anisotropy Dictates the Collective Behavior of Surface-Bound Ligands (2011)

We report on the modification of the properties of surface-confined ligands in nanoparticle systems through the introduction of shape anisotropy. Specifically, triangular gold nanoprisms, densely functionalized with oligonucleotide ligands, hybridize to complementary particles with an affinity that is several million times higher than that of spherical nanoparticle conjugates functionalized with the same amount of DNA. In addition, they exhibit association rates that are 2 orders of magnitude greater than those of their spherical counterparts. This phenomenon stems from the ability of the flat, extended facets of nonspherical nanoparticles to (1) support more numerous ligand interactions through greater surface contact with complementary particles, (2) increase the effective local concentration of terminal DNA nucleotides that mediate hybridization, and (3) relieve the conformational stresses imposed on nanoparticle-bound ligands participating in interactions between curved surfaces. Finally, these same trends are observed for the pH-mediated association of nanoparticles functionalized with carboxylate ligands, demonstrating the generality of these findings.
Planar Schottky Diodes on High Quality A-plane GaN (2003)

We report on the fabrication and characterization of Schottky diodes on a-plane GaN layers grown by epitaxial lateral overgrowth (ELOG) over r-plane sapphire. An unintentional electron doping concentration of 2.4×1017 cm-3 with an electron mobility value of 400 cm2/V·s and a hole diffusion length of 2.8 µm was measured for the ELOG a-plane GaN film, confirming its high quality. Planar Schottky diodes located in the lateral overgrowth region show an ideality factor as low as 1.1. The demonstrated feasibility of Schottky barriers and ohmic contacts to ELOG a-plane GaN opens up the possibility of fabricating non-polar electron devices.
Reliable Parameter Extraction of Asymmetric GaN-Based Heterojunction Field Effect Transistors (2018)

A novel reliable small signal model parameter extraction of asymmetric GaN-based Heterojunction Field Effect Transistors (HFETs) is proposed in this paper. An efficient systematic searching procedure based on pinch-off and cold weak-forward S-parameters has been developed to consider the asymmetric structure of GaN HFETs and find the optimal values of the gate and drain pad capacitances Cpg and Cpd. Considering that the depletion region extension is varied with the gate bias voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gs</sub> slightly even below pinch-off voltage, the obtained initial values of the extracted parameters are optimized by artificial bee colony (ABC) algorithm to improve the reliability of parameter extraction. The developed parameter extraction method shows excellent accuracy and reliability. The proposed procedure can be extended to asymmetric GaN devices with various process technologies. The developed approach has been validated by an asymmetric 0.15 μm GaN HFET over a wide range of bias conditions and frequencies.
Induction of Sensitization and Resistance to Transplant Tolerance by Allogeneic Pregnancy (2017)

Introduction: Clinical data suggest allogeneic pregnancy is a sensitizing event[1][2]; yet, recent data from mouse models suggest it induces fetal-specific regulatory T cell (Treg) expansion and differentiation into memory Tregs that mediate systemic, fetal-specific immune regulation post-partum (PP)[3][4]. In this study, we sought to define the immunological consequences of allogeneic pregnancy for the induction of allograft tolerance in mice. Methods: Virgin female B/6 mice were mated with male B/c-2 W-OVA transgenic mice and conception date was confirmed with visualization of a copulation plug. Fetal-specific CD4+ and CD8+ T cell responses were tracked PP using 2 W:I-Ab and OVA:Kb tetramers, and fetal-specific antibodies were monitored using B/c targets and flow cytometry. At PP day 30–45, F1 (B/6 x B/c)-2 W-OVA heart transplants were performed and recipients were treated with anti-CD154 (POD 0, 7, 14) and donor-specific splenocytes (POD 0) to induce tolerance. Graft rejection was determined by direct palpation. Results: PP females demonstrated a fifteen-fold increase in total number of fetal-specific Tregs and seven-fold increase in number of fetal-specific conventional CD4+ and CD8+ T cells (Tconvs) at PP day 30–45, compared to virgin controls. 2 W:IAb CD4+ Tconvs showed modestly increased expression of markers of anergy (CD44+FR4+CD73+: 20% PP vs 6% V) and OVA:Kb CD8+ Tconvs markers of exhaustion (PD-1: 10% PP vs 0% V). Fetal-specific antibodies increased throughout pregnancy to a peak three-fold increase by PP day 30–45. 7 of 10 PP mice rejected their heart graft by day 21–28 post-transplant, while all virgin mice (N = 25) accepted their grafts for > 60 days (Fig 1). Conclusion: Despite sustained expansion of maternal FoxP3+ Tregs with fetal/allograft-specificity and acquisition of Tconvs with an anergic/exhausted phenotype, allogeneic pregnancy induced fetal-specific antibodies and a resistance to transplant tolerance.FIGURE 1: Pregnancy induces sensitization and an acquired resistance toCoB-induced transplant tolerance.Whwn PPmicewere used as recipients of F1-2W-OVA heart grafts and treated with costimulatory blockade (CoB: anti-CD154 and donor-specific splenocytes) to induced tolerance, 7 of 10 PP mice were rejected their graft by 21-28 postransplant. In contrast, all virgin B/6 mice (N=25) accepted thier F1-2W-OVA heart grafts for >60 days.References: 1. Redfield RR, Scalea JR, Zens TJ, et al. The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients. Nephrol Dial Transplant. 2016; 31(10):1746-53. 2. Porrett P, Bromberger B, Hashmi S, Morrison A, Sawinski D. Pregnancy excludes women from successful living donor transplantation. Am J Transplant. 2016; 16 (suppl 3). 3. Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature. 2012; 490(7418):102-106. 4. Kalekar LA, Schmiel SE, Nandiwada SL et al. CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nature. 2016; 17(3): 304-15.