gebhart/patrepeval huggingface dataset:
Feasibility of long-distance transport of thermal energy using solid sorption processes (2009)

This paper deals with the challenging transportation of thermal energy over long distances (over 10 km). The innovative concept presented in this paper is based on the transportation of a reactive fluid coupled with two sorption systems involving this fluid in two endothermal and exothermal processes respectively on source site and user site. The transport of this fluid at ambient temperature minimizes the thermal losses and it is therefore relevant for long distances. Moreover, an original concept involving a cascade of two sorption cycles can allow a heat upgrading on the user site using a distant source. This paper focuses on the feasibility of such systems. The potentialities have been detailed according to the reactive pairs, such as the well-known hydrates and ammonia solid/gas reactants, and taking into account thermodynamic and technological constraints. The cold production and transport can be carried out by numerous ammonia-based pairs. Nevertheless, such reactive pairs can perform a heat upgrading, but only if an additional heat source is available on the user site. The transportation of the reactive fluid between source and user sites has been investigated and it is not a limiting point. As it is transported at ambient temperature, the thermal losses are very weak. On the other hand, the pressure losses can be overcome with either an acceptable energetic cost or by slightly changing the operating conditions. Compared to current district heating networks based on sensible heat transportation, such thermochemical systems involving the transportation of a reactive fluid seem more efficient when the user is located more than 10 km away from the source site. Copyright © 2009 John Wiley & Sons, Ltd.
Formylpeptide receptors in GtoPdb v.2021.2 (2021)

The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [196]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as lipoxin A4 (LXA4), 15-epi-lipoxin A4, annexin I , cathepsin G, amyloid β42, serum amyloid A and spinorphin, derived from β-haemoglobin. FPR1 also serves as a plague receptor for selective destruction of human immune cells by Y. pestis [135]. The FPR1/2 agonists 'compound 17b' and 'compound 43' have shown cardiac protective functions [149, 64].
Supplementary Table S4 from Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer (2023)

&lt;p&gt;Secondary mini-pool overexpression screen data&lt;/p&gt;
Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit ofVitis coignetiaePulliat is Associated with the Activation of AMPK Signaling Pathway (2018)

Anthocyanins are naturally occurring water-soluble polyphenolic pigments in plants that have been shown to protect against cardiovascular diseases, and certain cancers, as well as other chronic human disorders. However, the anti-obesity effects of anthocyanins are not fully understood. In this study, we investigated the effects of anthocyanins isolated from the fruit of <i>Vitis coignetiae</i> Pulliat on the adipogenesis of 3T3-L1 preadipocytes. Our data indicated that anthocyanins attenuated the terminal differentiation of 3T3-L1 preadipocytes, as confirmed by a decrease in the number of lipid droplets, lipid content, and triglyceride production. During this process, anthocyanins effectively enhanced the activation of the AMP-activated protein kinase (AMPK); however, this phenomenon was inhibited by the co-treatment of compound C, an inhibitor of AMPK. Anthocyanins also inhibited the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding protein a and b, and sterol regulatory element-binding protein-1c. In addition, anthocyanins were found to potently inhibit the expression of adipocyte-specific genes, including adipocyte fatty acid-binding protein, leptin, and fatty acid synthase. These results indicate that anthocyanins have potent anti-obesity effects due to the inhibition of adipocyte differentiation and adipogenesis, and thus may have applications as a potential source for an anti-obesity functional food agent.
Enantioselektive katalytische Transfer‐Hydrierung von α,β‐ungesättigten Carbonsäuren mit Triethylammoniumformiat (1988)

Als Hydrierung ohne molekularen Wasserstoff empfiehlt sich die Transfer‐Hydrierung mit Triethylammoniumformiat (= Ameisensäure + NEt 3 ). In Gegenwart von Rhodiumkomplexen mit optisch aktiven Liganden wie (−)‐Diop werden bei der katalytischen Hydrierung von Acetylaminozimtsäure und Itaconsäure Enantiomerenüberschüsse erreicht, die denen der Hydrierung mit molekularem Wasserstoff nahe kommen oder sie sogar übertreffen. magnified image
Regulatory modules that generate biphasic signal response in biological systems (2004)

Biochemical networks might be composed of modules. It is still not clear how biochemical modules can be defined and characterised. Here we propose a functional approach to module definition, considering different classes of biphasic regulation modules, which effect optimal cell response to intermediate signal strength. Each regulation class might possess unique properties that make it especially suitable for particular biological functions.
Under 0.5W 50Gb/s full-rate 4:1MUX and 1:4 DEMUX in 0.13μm InP HEMT technology (2004)

50Gb/s full-rate 4:1 MUX and 1:4 DEMUX ICs are fabricated in an InP HEMT technology. The MUX has an rms jitter of 283fs and a peak-to-peak jitter of 1.78ps. The DEMUX has a phase margin of 250/spl deg/ and a sensitivity of 80mV at 40Gb/s. The MUX and DEMUX consume 450mW and 490mW from a -1.5V supply, respectively.
Regulation and Standardization Activities Related to Spectrum Sharing (2020)

Fifth-generation (5G) communication systems are designed to provide a 1000× to 10,000× capacity increase compared to legacy fourth-generation technology. Such objectives imply the need for substantial additional spectral resources which are made available through multiple strategies. A new technology has been introduced targeting shared exploitation of television broadcast bands, also known as TV white spaces (TVWSs) spectrum. This chapter outlines the second generation of spectrum sharing technology after a previous but commercially unsuccessful initiative in the context of TVWS technology. It presents an overview of the standards and regulation activities. The chapter explains how European Telecommunications Standards Institute and European Conference of Postal and Telecommunication Administration (CEPT) collaborate in order to ensure that the licensed shared access (LSA) standardization output and the regulation framework are well aligned and suitably complement each other. From a regulatory perspective for LSA, the European CEPT organization has acted following investigations and a corresponding mandate by the European Commission.
AnCo3, a New Member of the Emerging Family of Phage-Like Plasmids (2017)

A phage-like plasmid isolated from a clinical isolate of <i>Salmonella enterica</i> serovar Derby has strong nucleotide sequence identity to the phage-like plasmids pSTM_phi isolated from <i>Salmonella enterica</i> serovar Typhimurium L495, AnCo1 and AnCo2 from <i>Escherichia coli</i> 243 and <i>Escherichia coli</i> 244, and the virulent <i>Salmonella</i>-specific SSU5 bacteriophage.
Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis (2020)

The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have found that a high proportion of proliferating macrophages in human tumors express ERK5. ERK5 was required for supporting the proliferation of macrophages in tumor grafts in mice. Furthermore, myeloid ERK5 deficiency negatively impacted the proliferation of both resident and infiltrated macrophages in metastatic lung nodules. ERK5 maintained the capacity of macrophages to proliferate by suppressing p21 expression to halt their differentiation program. Collectively, these data provide insight into the mechanism underpinning macrophage proliferation to support malignant tumor development, thereby strengthening the value of ERK5-targeted therapies to restore antitumor immunity through the blockade of protumorigenic macrophage activation. SIGNIFICANCE: These findings offer a new rationale for anti-ERK5 therapy to improve cancer patient outcomes by blocking the proliferative activity of tumor macrophages.
Neutralizing antibodies during treatment of secondary progressive MS with interferon β-1b (2003)

These results support the conclusion that even though high NAB titers appear to have impact on treatment efficacy with respect to relapses, treatment decisions should be based primarily on clinical grounds.
Supplementary Figure Legends from Human Leukocyte Antigen–Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer (2023)

&lt;p&gt;Supplementary Figure Legends for S1-S3.&lt;/p&gt;
A 2014 Mbin/s deeply pipelined CABAC decoder for HEVC (2014)

High Efficiency Video Coding (HEVC) is the latest video standard that specifies video resolutions up to 8K Ultra-HD (UHD) at 120 fps to support the next decade of video applications. This results in high throughput requirements for the Context Adaptive Binary Arithmetic Coding (CABAC) entropy decoder, which was already a well-known bottleneck in H.264/AVC. Several modifications were made to the HEVC CABAC to address the throughput challenges. This work leverages these improvements in the design of a high throughput HEVC CABAC decoder. The proposed design uses a deeply pipelined architecture to achieve a high clock rate. Additional techniques such as state prefetch logic, latched-based context memory, and separate finite state machines are applied to minimize stall cycles, while multi-bypass bins decoding is used to further increase the throughput. The design is synthesized in a IBM 45nm SOI process, and achieves throughputs up to 2014 and 2748 Mbin/s under common and worst-case test conditions, respectively, at 1.9 GHz operating frequency. The results show that the design is sufficient to decode video bitstreams in real-time at Level 6.2, or at Level 6.0 for applications requiring sub-frame latency.
On the delay advantage of coding in packet erasure networks (2010)

We consider the delay of network coding compared to routing for a family of simple networks with parallel links. We investigate the sub-linear term in the block delay required for unicasting n packets and show that there is an unbounded gap between network coding and routing. In particular, we show that delay benefit of network coding is scaling at least as fast as √n. The main technical contribution involves showing that the delay function for the routing retransmission strategy is unbounded. This problem is equivalent to computing the expected maximum of two negative binomial random variables. This problem has also been addressed previously and we derive the first exact characterization which might be of independent interest.
Learning a projective mapping to locate animals in video using RFID (2012)

We present a method to locate animals in video based on their reported positions using noisy and biased measurements from a radio frequency identification (RFID) system. The system uses a kernel regression method to learn a mapping from reported X, Y, Z locations in the environment to X, Y pixel locations in video with minimal calibration and training data. Our goal is for this system to facilitate animal behavior research by enabling automatic identification of interactions between animals and then providing the location of the animals in video so that the details of each interaction can be examined more closely by either humans or machines. The primary contribution of this work is achieving efficient and reliable 3D to 2D projective mapping in a non-parametric way while also overcoming challenges that would otherwise affect accuracy. Our system successfully addresses issues regarding noisy positional data, position bias, occlusion of RFID tags, and wide angle lens distortion. We validate the system experimentally indoors as well as in the field and compare the accuracy of our system with the standard camera projection model-based procedure.
Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function (2018)

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to study its biological role. MALT1 has recently been suggested as a therapeutic target in rheumatoid arthritis. Here, we analyzed the effect of mepazine on the receptor activator of nuclear factor κ-B (RANK)-induced osteoclastogenesis. The treatment of mouse bone marrow precursor cells with mepazine strongly inhibited the RANK ligand (RANKL)-induced formation of osteoclasts, as well as the expression of several osteoclast markers, such as TRAP, cathepsin K, and calcitonin. However, RANKL induced osteoclastogenesis equally well in bone marrow cells derived from wild-type and <i>Malt1</i> knock-out mice. Furthermore, the protective effect of mepazine was not affected by MALT1 deficiency. Additionally, the absence of MALT1 did not affect RANK-induced nuclear factor κB (NF-κB) and activator protein 1 (AP-1) activation. Overall, these studies demonstrate that MALT1 is not essential for RANK-induced osteoclastogenesis, and implicate a MALT1-independent mechanism of action of mepazine that should be taken into account in future studies using this compound.
Indirect frequency synthesizer using second order digital time delay tanlock loop (2008)

This paper presents a new indirect frequency synthesizer based on a digital time delay tanlock loop. The loop used is a second order one and that results in a zero steady state error once the system is in lock. The process of locking the complete system following the introduction of the divider is achieved through the incorporation of a special adaptive locking mechanism. The adaptation block includes a finite state machine that eventually controls the loop digital filter and the digital controlled oscillator.
Requirements for discrete actuator and segmented wavefront correctors for aberration compensation in two large populations of human eyes (2007)

Numerous types of wavefront correctors have been employed in adaptive optics (AO) systems for correcting the ocular wavefront aberration. While all have improved image quality, none have yielded diffraction-limited imaging for large pupils (>/=6 mm), where the aberrations are most severe and the benefit of AO the greatest. To this end, we modeled the performance of discrete actuator, segmented piston-only, and segmented piston/tip/tilt wavefront correctors in conjunction with wavefront aberrations measured on normal human eyes in two large populations. The wavefront error was found to be as large as 53 microm, depending heavily on the pupil diameter (2-7.5 mm) and the particular refractive state. The required actuator number for diffraction-limited imaging was determined for three pupil sizes (4.5, 6, and 7.5 mm), three second-order aberration states, and four imaging wavelengths (0.4, 0.6, 0.8, and 1.0 microm). The number across the pupil varied from only a few actuators in the discrete case to greater than 100 for the piston-only corrector. The results presented will help guide the development of wavefront correctors for the next generation of ophthalmic instrumentation.
Sampling Techniques (2017)

Aerosol collection can be achieved through a myriad of techniques. These techniques can be used to select aerosols based on their size and nature. Typical techniques include passive sampling, air filtration, liquid- or solid-phase inertial impaction, and electrostatic sampling. The sampling method selected must be guided by the scientific questions posed and be compatible with specific downstream analytical procedures targeting the bioaerosols of interest. Here we present examples of the most frequently used offline aerosol sampling techniques applied for bioaerosol collection, i.e., methods not directly coupled with analyses.
Acoustic Array Processing for Speech Enhancement (2010)

This chapter contains sections titled: Introduction Signal Processing in Subband Domain Multichannel Echo Cancellation Speaker Localization Beamforming Sensor Calibration Postprocessing Conclusions References
Antenna Deployment of 5G Ultra High-Density Distributed Massive MIMO by Low-SHF-Band Indoor and Outdoor Experiments (2017)

In order to tackle rapidly increasing traffic, distributed Massive MIMO (DM-MIMO) has been proposed for fifth-generation (5G) mobile communication systems. DM-MIMO coordinates lots of distributed transmission points (TPs) that are located in ultra-high density (UHD) and that use an appropriate number of antenna elements. Furthermore, DM-MIMO with UHD-TPs can create user-centric virtual cells corresponding to user mobility. To deploy TPs for DM-MIMO, some key parameters such as the number of the distributed TPs, the number of antenna elements for each TP, and proper distance between TPs should be determined. Conventional works have shown such key parameters for DM-MIMO with UHD-TPs by computer simulations. However, these parameters have not been evaluated in actual deployment environments. We measure low-SHF- band (4.5 GHz) radio propagation channel in indoor and outdoor experiments of DM-MIMO with UHD-TPs. Then, by exploiting the experimental results, the appropriate numbers of antenna elements based on maximum system throughput criterion are shown for 5G DM-MIMO by computer simulations.
CHAPTER 1. Supramolecular Approaches to Protein Recognition (2020)

This chapter begins with an account of the early developments in protein chemistry and supramolecular chemistry. We have attempted to summarize the seminal achievements in each of these vast fields, highlighting how one has informed the other over the past century. We focus on the central topic of molecular recognition and noncovalent interactions. Classic examples of molecular recognition in Nature (as evidenced by X-ray crystallography) and the corresponding motifs developed by supramolecular chemists are described. Synthetic scaffolds that mimic peptide and protein structures are also presented in the context of interaction inhibitors. By bringing together these illustrious examples we hope to encourage new collaborations between supramolecular chemists and biomedical scientists.
An analysis on the possibility of using capacitors of a three-level capacitor clamped inverter as power smoothing elements for wind power systems (2011)

This paper presents a new direct integration scheme for supercapacitors that are used to mitigate short term power fluctuations in wind power systems. The idea is to replace ordinary capacitors of a 3-level flying capacitor inverter by supercapacitors and operate them under variable voltage conditions. This approach eliminates the need of interfacing dc-dc converters for supercapacitor integration and thus considerably improves the overall efficiency. However, the major problem of this unique system is the change of supercapacitor voltages. An analysis on the effects of these voltage variations are presented. A space vector modulation method, built from the scratch, is proposed to generate undistorted current even in the presence of dynamic changes in supercapacitor voltages. A supercapacitor voltage equalisation algorithm is also proposed. Furthermore, resistive behavior of supercapacitors at high frequencies and the need for a low pass filter are highlighted. Simulation results are presented to verify the efficacy of the proposed system in suppressing short term wind power fluctuations.
Supplementary Figure S1 from Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;p&gt;Graph showing IC50 values for USPC-ARK-1 cell line after 72 hrs exposure to increasing concentration of neratinib.&lt;/p&gt;
Cytokinin signaling in Mycobacterium tuberculosis (2017)

Summary It was reported the human-exclusive pathogen Mycobacterium (M.) tuberculosis secretes cytokinins, which previously had only been known as plant hormones. Cytokinins are adenine-based signaling molecules in plants that have never been shown to participate in signal transduction in other kingdoms of life. Here, we show that cytokinins induce the strong expression of the M. tuberculosis gene, Rv0077c. We found that a TetR-like transcriptional regulator, Rv0078, directly repressed expression of the Rv0077c gene. Strikingly, cytokinin-induced expression of Rv0077c resulted in a loss of acid-fast staining of M. tuberculosis . Although acid-fast staining is thought to be associated with changes in the bacterial cell envelope and virulence, Rv0077c-induced loss of acid-fastness did not affect antibiotic susceptibility or attenuate bacterial growth in mice. Collectively, these findings show cytokinins signal transcriptional changes that affect the M. tuberculosis cell envelope, and that cytokinin signaling is no longer limited to the kingdom plantae.
Peptides for Diagnosis and Treatment of Colorectal Cancer (2014)

Colorectal cancer (CRC) is a major health concern worldwide, as it is the third most frequently diagnosed cancer and the second leading cause of cancer-related death. There are a number of treatment options for CRC, however many of them are disappointing. Therefore, significant efforts are directed towards the development of new biological therapies with improved efficacy. The use of peptides in CRC treatment holds promise as emerging novel anti-cancer agents. Targeted therapy based on the use of peptides that can directly target tumor cells without affecting normal cells is evolving as an alternative strategy to conventional therapies and particularly, chemotherapy. The main advantages of peptides are their relatively easy and rapid synthesis process, and the vast possibilities for chemical modifications that can be exploited for novel peptide design and improved delivery. Peptides can be utilized directly as cytotoxic agents or indirectly as they can act as carriers of cytotoxic agents, drugs, or radioisotopes by specifically targeting tumor cells. They can also be used for diagnostic purposes. Current research focuses on developing peptides that can serve as tumor targeting moieties, permeabilize membranes to induce cytotoxicy, radiolabeled peptides, and peptide vaccines. In addition, improving targeting to tumors, reducing side effects, due to non-specific toxicity, and unraveling the pharmacokinetic characteristics of potential peptides, for either therapeutic or diagnostic use, are also subjects of intensive investigation. This review provides a brief overview on the role of peptides in CRC diagnosis and therapy that are currently being investigated, and their potential applications in the clinical setting.