gebhart/patrepeval huggingface dataset:
HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum (2012)

Soilborne fungal pathogens cause devastating yield losses and are highly persistent and difficult to control. During the infection process, these organisms must cope with limited availability of iron. Here we show that the bZIP protein HapX functions as a key regulator of iron homeostasis and virulence in the vascular wilt fungus Fusarium oxysporum. Deletion of hapX does not affect iron uptake but causes derepression of genes involved in iron-consuming pathways, leading to impaired growth under iron-depleted conditions. F. oxysporum strains lacking HapX are reduced in their capacity to invade and kill tomato (Solanum lycopersicum) plants and immunodepressed mice. The virulence defect of ΔhapX on tomato plants is exacerbated by coinoculation of roots with a biocontrol strain of Pseudomonas putida, but not with a siderophore-deficient mutant, indicating that HapX contributes to iron competition of F. oxysporum in the tomato rhizosphere. These results establish a conserved role for HapX-mediated iron homeostasis in fungal infection of plants and mammals.
Implementation of a FFT radix 2 butterfly using serial RSFQ multiplier-adders (1995)

We have designed a Decimation-in-Time (DIT) radix 2 butterfly integrated circuit. This circuit will be used to implement the 32-point Fast Fourier Transform (FFT) in a parallel data flow architecture. The radix 2 butterfly circuit uses serial RSFQ math and consists of four single bit-wide serial multipliers and eight carry-save serial adders. The circuit with 16-bit word-length employs only 3400 junctions, occupies an area of 3.8/spl times/2.0 mm/sup 2/, and dissipates less than 1.1 mW power. The multiplier is implemented using the unique RSFQ bit-clock-pipelined schema. We have successfully tested a library of serial multiply-add elements: the 8-bit multiplier at 6.3 GHz and adders with dc bias margin /spl plusmn/20%. Finally, we have demonstrated full operation of the radix 2 butterfly chip with 5-bit word length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies (2021)

A library of novel naproxen based 1,3,4-oxadiazole derivatives (<b>8</b>-<b>16</b> and <b>19</b>-<b>26</b>) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((<i>S</i>)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)methyl)-1<i>H</i>-1,2,3-triazol-1-yl)phenol(<b>15</b>) was the most potent compound against MCF-7 and HepG2cancer cells with IC<sub>50</sub> of 2.13 and 1.63 µg/mL, respectively, and was equipotent to doxorubicin (IC<sub>50</sub> 1.62 µg/mL) towards HepG2. Furthermore, compound <b>15</b> inhibited EGFR kinase with IC<sub>50</sub> 0.41 μM compared to standard drug Erlotinib (IC<sub>50</sub> 0.30 μM). The active compound induces a high percentage of necrosis towards MCF-7, HePG2 and HCT 116 cells. The docking studies, DFT and MEP also supported the biological data. These results demonstrated that these synthesized naproxen hybrids have EGFR inhibition effects and can be used as leads for cancer therapy.
Cooperative Resolvability and Secrecy in the Cribbing Multiple-Access\n Channel (2018)

We study channel resolvability for the discrete memoryless multiple-access\nchannel with cribbing, i.e., the characterization of the amount of randomness\nrequired at the inputs to approximately produce a chosen i.i.d. output\ndistribution according to KL divergence. We analyze resolvability rates when\none encoder cribs (i) the input of the other encoder; or the output of the\nother encoder, (ii) non-causally, (iii) causally, or (iv) strictly-causally.\nFor scenarios (i)-(iii), we exactly characterize the channel resolvability\nregion. For (iv), we provide inner and outer bounds for the channel\nresolvability region; the crux of our achievability result is to handle the\nstrict causality constraint with a block-Markov coding scheme in which\ndependencies across blocks are suitably hidden. Finally, we leverage the\nchannel resolvability results to derive achievable secrecy rate regions for\neach of the cribbing scenarios under strong secrecy constraints.\n
64.2: Full Color 100 dpi AMOLED Displays on Flexible Stainless Steel Substrates (2006)

Abstract We demonstrate full color, top emission, active matrix OLED displays on flexible stainless steel substrates. The 100 dpi QVGA displays are driven by LTPS TFT backplane with excimer laser annealed poly‐Si. To our knowledge this is the world's highest resolution full color flexible AMOLED display on steel foil demonstrated to date. Encapsulation is by a multilayer thin film.
Guiding of long-range surface plasmon polaritons along channels in periodic arrays of scatterers (2004)

We investigate waveguiding of long-range surface plasmon polaritons in periodic arrays of scatterers at telecommunication wavelengths. A propagation loss of approximately 6 dB/mm and a coupling loss of 0.5 dB is reported for 8-µm-wide channels.
Mannose‐6‐Phosphate Receptor: A Target for Theranostics of Prostate Cancer (2015)

The development of personalized and non-invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over-expression of a membrane lectin, the cation-independent mannose 6-phosphate receptor (M6PR), was specifically demonstrated in prostate cancer cell lines and tissues. To efficiently target this lectin a mannose-6-phosphate analogue was synthesized in six steps and grafted onto the surface of functionalized mesoporous silica nanoparticles (MSNs). These MSNs were used for in vitro and ex vivo photodynamic therapy to treat prostate cancer cell lines and primary cell cultures prepared from patient biopsies. The results demonstrated the efficiency of M6PR targeting for prostate cancer theranostic.
In situ recovery of bio-based carboxylic acids (2018)

The economics of chemical and biological processes is often dominated by the expense of downstream product separations from dilute product streams.
Foundations for Smarter Cities (2010)

This paper describes the information technology (IT) foundation and principles for Smarter Cities™. Smarter Cities are urban areas that exploit operational data, such as that arising from traffic congestion, power consumption statistics, and public safety events, to optimize the operation of city services. The foundational concepts are instrumented, interconnected, and intelligent. <emphasis emphasistype="bold" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Instrumented</emphasis> refers to sources of near-real-time real-world data from both physical and virtual sensors. <emphasis emphasistype="bold" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Interconnected</emphasis> means the integration of those data into an enterprise computing platform and the communication of such information among the various city services. <emphasis emphasistype="bold" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Intelligent</emphasis> refers to the inclusion of complex analytics, modeling, optimization, and visualization in the operational business processes to make better operational decisions. This approach enables the adaptation of city services to the behavior of the inhabitants, which permits the optimal use of the available physical infrastructure and resources, for example, in sensing and controlling consumption of energy and water, managing waste processing and transportation systems, and applying optimization to achieve new efficiencies among these resources. Additional roles exist in intelligent interaction between the city and its inhabitants and further contribute to operational efficiency while maintaining or enhancing quality of life.
FECAL LACTOFERRIN MEASUREMENTS ARE USEFUL IN THE INTERVAL ASSESSMENT OF PATIENTS WITH ACTIVE AND INACTIVE INFLAMMATORY BOWEL DISEASE (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: INFLAMMATORY BOWEL DISEASE: PDF Only
Observation of defect formation in metamaterials (2008)

We report subwavelength localization of electromagnetic fields within cavities based on metamaterials. Cavity resonances are observed in the transmission spectrum of a split ring resonator and composite metamaterials cavity structures. These cavity resonances are shown to exhibit high quality factors. Since the unit cells of metamaterials are much smaller than the operation wavelength, subwavelength localization is possible within these metamaterial cavity structures. In the present paper, we show that the electromagnetic field is localized into a region of λ/8, where λ is the cavity resonance wavelength.
Total phenol content of guava fruit and development of an in vitro regeneration protocol amenable to genetic improvement (2011)

Total soluble phenolics in two white (‘Allahabad Safeda’ and ‘Lucknow-49’), two pink (‘Beaumont’ and ‘Gushiken Sweet’), and three red fleshed (‘Ka Hua Kola’, ‘Ruby Supreme’ and ‘Red Fleshed’) guava ( Psidium guajava L.) fruits were assessed using the Folin-Ciocalteu procedure. ‘Allahabad Safeda’ and ‘Ruby Supreme’ contained the highest level of phenols (1,967.5 and 1,921.25 μg/g gallic acid equivalents). No significant difference in phenolic content was observed between white and red fleshed guava fruits. An in vitro method was developed for clonal propagation of ‘Lucknow-49’ and ‘Gushiken Sweet’ cultivars. Five concentrations of six-benzylaminopurine (BAP) and kinetin (KIN) plant growth regulators were tested for in vitro regeneration. A maximum of 4.5 shoots per explant was produced on Murashige and Skoog medium supplemented with 8.9 μM BAP + 9.4 μM KIN. These studies indicate that guava, a rich source of natural phenolic antioxidants, can be efficiently micropropagated for genetic studies to enhance its nutraceutical value.
Simulation and stability of multi-port DC-DC converter (2014)

In this paper, the simulation and stability of multi-port DC-DC converter will be presented. Traditional DC-DC converter topologies interface two power terminals: a source and a load. The construction of diverse and flexible power management and distribution systems with such topologies is governed by a tight compromise between converter count, efficiency, and control complexity. The DC-DC converter may be considered as an advanced environment-friendly electronic conversion system, since it is a greenhouse emission eliminator. By utilizing the advancement of these renewable energy sources, we minimize the use of fossil fuel and thus contribute to a cleaner and pollution-free environment. Finally, comparison between the averaged model and the actual switching converter model is been studied.
"Microstrip-fed quasi-Yagi antenna array for a different DSRC system", (2012)

International audience
Antioxidants (2017)

Well before the mechanism of hydrocarbon oxidation was thoroughly investigated, researchers had come to understand that some oils provided greater resistance to oxidation than others. The difference was eventually identified as being due to naturally occurring antioxidants, which varied depending upon the nature of the crude oil, and refining techniques. Some of these natural antioxidants were found to contain sulfur- or nitrogen-bearing functional groups. An engine lubricant with antioxidant and corrosion inhibition characteristics was obtained from sulfurizing terpenes. Paraffin wax has also been employed to prepare sulfur compounds. Naturally occurring phosphorus compounds such as lecithin have been utilized as antioxidants, and many patents have been issued on these materials for use alone or in combination with other additives. Alkylated aromatic amines and hindered phenols are most important single-purpose, ashless antioxidants in many lubricant applications today. Organocopper compounds including copper naphthenates have been reported to be synergistic with multi-ring aromatic compounds in controlling high-temperature deposit formation in synthetic base oils.
Effect of admixed high‐density polyethylene (HDPE) spheres on contraction stress and properties of experimental composites (2003)

Additives that provide stress relief may be incorporated into dental composites to reduce contraction stress (CS). This study attempted to test the hypothesis that conventional fillers could be replaced by high-density polyethylene (HDPE) spheres in hybrid and nanofill composites to reduce CS, but with minimal effect on mechanical properties. Nanofill and hybrid composites were made from a Bis-GMA/TEGDMA resin having either all silica nanofiller or 75 wt.% strontium glass + 5 wt.% silica and replacing some of the nanofiller or the glass with 0%, 5% (hybrid only), 10% or 20 wt.% HDPE. The surface of the HDPE was either left untreated or had a reactive gas surface treatment (RGST). Contraction stress (CS) was monitored for 10 min in a tensilometer (n = 5) after light curing for 60 s at 390 mW/cm(2). Other specimens (n = 5) were light cured 40 s from two sides in a light-curing unit and aged 1 d in water before testing fracture toughness (K(Ic)), flexure strength (FS), and modulus (E). Results were analyzed by ANOVA with Tukey's multiple comparison test at p < 0.05. There was no difference between composites with RGST and untreated HDPE except for FS-10% HDPE hybrid (RGST higher). An increased level of HDPE reduced contraction stress for both types of composites. Flexure strength, modulus (hybrid only), and fracture toughness were also reduced as the concentration of HDPE increased. SEM showed evidence for HDPE debonding and plastic deformation during fracture of the hybrid composites. In conclusion, the addition of HDPE spheres reduces contraction stress in composites, either through stress relief or a reduction in elastic modulus.
Circumventing the Heisenberg principle: A rigorous demonstration of filter-diagonalization on a LiCN model (1994)

In a previous paper [J. Chem. Phys. 93, 2611 (1990)] a new method, filter diagonalization, was introduced for extracting highly excited rovibrational states from an arbitrary Hamiltonian, in any desired energy range. In the method, an arbitrary initial wave packet is propagated for a short time and during the propagation a ‘‘short time filter’’ of the wave packet is accumulated at various energies in any desired ‘‘window,’’ yielding a small set of functions which span the eigenfunctions of the Hamiltonian in the desired range. A small Hamiltonian matrix is then evaluated in the filtered-functions basis, to yield the eigenvalues in the desired range. The combination of the time-dependent (TD) propagation with the small matrix diagonalization eliminates the uncertainty-relation limitation associated with a pure TD approach and the large-matrix diagonalization necessary in a purely time-independent approach. In this paper we give the first demonstration of the power of filter diagonalization for a molecular Hamiltonian exhibiting accidental near degeneracies, thereby supplying a stringent test of our approach. A two-dimensional model of LiCN (J=0) is used. Good agreement is established with previous results for high-energy states. For a further check of consistency, we perform a large-scale direct diagonalization of the Hamiltonian, and verify a very-high accuracy even for nearly degenerate levels. Extraction of these levels by a purely TD approach would have necessitated ≊700-fold increase in propagation time.
Preparation of Tl-System Superconducting Thin Films by the Mist Microwave-Plasma Chemical Vapor Deposition Method (1994)

Superconducting thin films of Tl–Sr–Ca–Cu–O were prepared on single-crystal MgO(100) substrates by the mist microwave-plasma chemical vapor deposition method, and the dependence of T c-zero of films on the input molar ratio of oxygen O R =F O 2 /(F O 2 +total F A r ) was investigated. In addition, the effect of the Bi addition on Tl–Sr–Ca–Cu–O superconducting thin films was studied. The prepared films were constituted of the 1212 and/or 1223 phases with c -axis orientation perpendicular to the substrates. The maximum T c-zero (zero resistance; 102 K) of as-deposited films was obtained at the input molar ratio of oxygen ( O R ) of 0.30, the microwave power of 300 W and the addition amount ( x = Bi/(Tl+Bi)) of 0.30.
Estimation of the effects of angioplasty on coronary stenosis using quantitative video angiography (1985)

In this study, we compared stenosis severity by quantitative coronary angiography from video and cine images with visual estimation in 14 patients who underwent PTCA. Both cine and video analysis demonstrated a change from 65.2 +/- 2.5 to 36.5 +/- 3.1% diameter stenosis following PTCA, whereas visual estimation (average of three observers) showed improvement from 89.9 +/- 1.7 to 36.0 +/- 3.2%. Percent area stenosis from quantitative angiography showed improvement from 87.9 +/- 1.8 to 56.4 +/- 5.8. These data indicate that visual assessment overestimated percent diameter of severe lesions. To determine if video analysis could provide rapid quantitative assessment of PTCA results, we compared percent diameter and percent area stenosis by video with cine (diameter: correlation coefficient, 0.82; slope, 0.79; area: correlation coefficient, 0.86; slope, 0.83). These results indicate that video-based measurements are not different from cine-derived measurements. Quantitative coronary angiography provides an accurate estimate of changes produced by PTCA and can be performed rapidly and accurately on video images, thus making results available during the PTCA procedure.
Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones (2010)

The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1 H -benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl) - 1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1 H -benzo[ d ]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.
Cationic brush‐like terpolymer with pH responsive thickening behavior in a surfactant system (2014)

A new kind of cationic brush‐like terpolymer was synthesized by copper(I)‐mediated atom transfer radical polymerization ( ATRP ) of methyl ether poly(ethylene glycol) methacrylate ( mPEGMA ), poly(propylene glycol) methacrylate ( PPGMA ) and dimethylaminoethyl methacrylate ( DMAEMA ) in the presence of ethyl α‐bromoisobutyrate as ATRP initiator. The poly( PEG / PPG / DMAEMA ) terpolymer was featured with a cationic backbone containing PDMAEMA segments and amphiphilic side chains composed of hydrophilic PEG and hydrophobic PPG short branches. The copolymer was characterized by 1 H NMR , Fourier transform IR and gel permeation chromatography. The thickening behavior of this copolymer in a surfactant system (sodium dodecyl sulfate, SDS ) was extensively investigated by a rheological study. It was found that the copolymer can effectively thicken the SDS surfactant system at low concentrations of both copolymer and surfactant. More interestingly, the thickened SDS system by this copolymer showed dramatic pH responsive rheological behavior in the pH range 4–10. Thus the rheological behavior of the thickened SDS system was tunable by pH value. Based on our findings, a novel thickening mechanism is proposed for this kind of cationic brush‐like terpolymer. This kind of cationic brush‐like copolymer would be a new type of rheology modifier for advanced hair/skin care systems. © 2014 Society of Chemical Industry
Modeling: Possibilities and Limitations (2007)

No AccessCo-Rotating Twin-Screw ExtruderNov 2007Modeling: Possibilities and LimitationsKlemens KohlgrüberKlemens Kohlgrüberhttps://doi.org/10.3139/9783446433410.006SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2007Pages: 105-120Print ISBN: 978-3-446-41372-6eISBN: 978-3-446-43341-0 Copyright & Permissions© 2008 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Neural network pruning and hardware acceleration (2020)

Neural network pruning is a critical technique to efficiently deploy neural network models on edge devices with limited computing resources. Although many neural network pruning methods have been published, it is difficult to implement such algorithms due to their inherent complexity. In this work, we propose a functional pruning tool for neural network models. Our pruning procedure is simple and easy to be implemented, and efficient for deployment. Our pruning tool automatically detects redundancy inside neural network models and prunes the redundant channels. Doing so reduces the total number of model parameters and hence, compresses the size of the model. This approach significantly reduces the number of FLOPs needed for executing the neural network model and improves the inference runtime. To further improve the inference runtime of the pruned model, we leveraged Apache TVM to deploy the pruned model on the DPU FPGA-based hardware accelerator. To demonstrate our approach, we pruned the VGG-16 model on Flower dataset and reached 53-fold reduction in model size with only 7% drop in validation accuracy. The inference latency is reduced 4-fold on CPU and 16-fold on FPGA for the pruned models, compared with the latency of the base model on CPU.
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group (2020)

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.