gebhart/patrepeval huggingface dataset:
Tilted grating phase-contrast computed tomography using statistical iterative reconstruction (2018)

Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only the differential phase-contrast (DPC) signal perpendicular to the direction of the grating lines. Having access to the full two-dimensional DPC signal can strongly reduce streak artefacts showing up as characteristic horizontal lines in the reconstructed images. GBPC-CT with gratings tilted by 45° around the optical axis, combining opposed projections, and reconstructing with filtered backprojection is one method to retrieve the full three-dimensional DPC signal. This approach improves the quality of the tomographic data as already demonstrated at a synchrotron facility. However, additional processing and interpolation is necessary, and the approach fails when dealing with cone-beam geometry setups. In this work, we employ the tilted grating configuration with a laboratory GBPC-CT setup with cone-beam geometry and use statistical iterative reconstruction (SIR) with a forward model accounting for diagonal grating alignment. Our results show a strong reduction of streak artefacts and significant increase in image quality. In contrast to the prior approach our proposed method can be used in a laboratory environment due to its cone-beam compatibility.
Supplementary Table S5 from ER-851, a Novel Selective Inhibitor of AXL, Overcomes Resistance to Antimitotic Drugs (2023)

&lt;p&gt;Supplementary Data Table S5&lt;/p&gt;
Endoglin deficiency elicits hypoxia-driven congestive heart failure in zebrafish (2021)

Abstract Hereditary hemorrhagic Telangiectasia (HHT) is a rare genetic disease relying on mutations affecting components of Bone Morphogenetic Protein and Transforming Growth Factor-β (BMP/TGF-β) signaling pathway in endothelial cells. This disorder is characterized by arterio-venous malformations prone to rupture. and ensuing hemorrhages are responsible for iron deficiency anemia. Along with Activin receptor-like kinase ALK1, Endoglin is involved in the vast majority of HHT cases. In this report, we characterized zebrafish endoglin locus and demonstrated that it produces two phylogenetically conserved protein isoforms using a distinctive alternative splicing mechanism. Functional analysis of a Crispr/Cas9 zebrafish Endoglin mutant revealed that Endoglin deficiency results in massive death during the course from juvenile stage to adulthood. Endoglin deficient fish develop a cardiomegaly resulting in heart failure and hypochromic anemia which both stem from chronic hypoxia. Histological analysis and confocal imaging evidenced structural alterations of the developing gill and its underlying vascular network that tally with hypoxia. Finally, phenylhydrazine treatment demonstrated that lowering hematocrit/blood viscosity alleviates heart failure and enhances survival of Endoglin deficient fish. Altogether, our data indicate that Endoglin is crucial for gill vascular development and that further studies using zebrafish in general and this endoglin mutant in particular will provide crucial hints regarding the molecular and cellular events altered in HHT for the development of new therapeutic strategies. Summary Statement Endoglin deficiency in zebrafish recapitulates critical aspects of Hereditary Hemorrhagic Telangiectasia (HHT) and will thus constitute a valuable model in large scale screens for HHT-active drugs.
Thermally sprayed coatings resistant to environmental degradation: Columnar-like coatings through laser ablation and surface melting approach (2023)

The limited lifespan of protective coatings attracted interest in studying the failure phenomena and investigating various coating deposition techniques. In this study, a new laser modification technique is proposed and examined on air plasma sprayed thermal barrier coatings. Thermal barrier coatings must have a minimal mechanical response to temperature variations, i.e. thermal expansion-induced stresses while having low thermal conductivity and excellent resistance to environmental agents. This paper reports a novel post-treatment approach allowing independent control of the elastic modulus in the coating and on its surface by creating a hollow internal anatomy covered by a dense protective layer. The hollow internal microstructure aims to recreate a columnar-like structure in air plasma sprayed coatings inspired by the electron-beam physical vapour deposited coatings, known for their excellent strain tolerance properties. To protect the coating from chemical and mechanical degradation and to cut the generated oxygen short path, the top surface of the coating is subsequently melted with a continuous-wave laser, creating a dense erosion and corrosion-resistant surface. The modification approach was applied to the state-of-the-art air plasma sprayed 8 wt% Yttria Stabilized Zirconia topcoats and comprehensively benchmarked against the same air plasma sprayed, non-modified, coating in terms of thermal shock, erosion resistance and response to molten silicon sand penetration, and showed significant improvements in erosion and CMAS tests, and 11 % improvement of thermal fatigue.
Genomic mining of prokaryotic repressors for orthogonal logic gates (2013)

Genetic circuits perform computational operations based on interactions between freely diffusing molecules within a cell. When transcription factors are combined to build a circuit, unintended interactions can disrupt its function. Here, we apply 'part mining' to build a library of 73 TetR-family repressors gleaned from prokaryotic genomes. The operators of a subset were determined using an in vitro method, and this information was used to build synthetic promoters. The promoters and repressors were screened for cross-reactions. Of these, 16 were identified that both strongly repress their cognate promoter (5- to 207-fold) and exhibit minimal interactions with other promoters. Each repressor-promoter pair was converted to a NOT gate and characterized. Used as a set of 16 NOT/NOR gates, there are >10[superscript 54] circuits that could be built by changing the pattern of input and output promoters. This represents a large set of compatible gates that can be used to construct user-defined circuits.
Modeling the Indoor Channel for the MIMO System using Dual Polarization Antennas (2006)

This work presents a quasi-three dimensional MIMO channel model to predict the polarization characteristics of an indoor radio channel. The model considers not only the effects of the polarization of the transmitting and receiving antenna elements, but also the types of indoor environment scatterers. The proposed model is based on an ellipse model and a patch scattering model. Furthermore, the channel model expands the ellipse model to a quasi-three dimensional model. The proposed model is suitable for indoor MIMO channels and can expect ergodic capacities of a multi-polarized MIMO channel, which considers polarization and 3-D geometry
Un naturaliste aux Terres australes: Jean-Baptiste Leschenault de La Tour (1773-1826) (2010)

http://www.editions-universite-bruxelles.be/fiche/view/2643
Efficient generation of the 7th harmonic of Ti:sapphire (114.6 nm) vacuum ultraviolet pulses with 60 fs duration by non-collinear four-wave mixing in argon (2022)

The recent advances in femtosecond vacuum UV (VUV) pulse generation, pioneered by the work of Noack et al., has enabled new experiments in ultrafast time-resolved spectroscopy. Expanding on this work, we report the generation of 60 fs VUV pulses at the 7th harmonic of Ti:sapphire with more than 50 nJ of pulse energy at a repetition rate of 1 kHz. The 114.6 nm pulses are produced using non-collinear four-wave difference-frequency mixing in argon. The non-collinear geometry increases the phase-matching pressure, and results in a conversion efficiency of ∼10<sup>-3</sup> from the 200 nm pump beam. The VUV pulses are pre-chirp-compensated for material dispersion with xenon, which has negative dispersion in this wavelength range, thus allowing almost transform-limited pulses to be delivered to the experimental chamber.
Development of High-Strength Steel Line Pipe For SBD Applications (2008)

A strain-based design (SBD) has been widely discussed in recent years. Line pipes for the design applications are required to have high deformability as well as toughness and weldability. We studied how to simultaneously improve toughness and deformability in high-strength steel line pipes through laboratory work. A dual-phase (bainite/ferrite) microstructure was effective, and the optimized volume fraction and grain size of polygonal ferrite were confirmed. In addition, we revealed that the accelerated cooling condition in hot rolling absolutely correlated with thermal aging during anti-coating treatment. Based on the experimental results, we experimentally manufactured X80 UOE pipes for SBD.
Resolution enhancement of low resolution wavefields with POCS algorithm (2003)

The problem of enhancing the resolution of wavefield or beam profile measurements obtained using low resolution sensors is addressed by solving the problem of interpolating signals from partial fractional Fourier transform information in several domains. The iterative interpolation algorithm employed is based on the method of projections onto convex sets (POCS).
Evolution of Automated Peritoneal Dialysis Machines (2019)

Peritoneal dialysis (PD) has undergone several improvements over the years. Among the numerous advances, we may recall the improvement in the quality of fluids, safety of catheters and connections, knowledge of the peritoneal membrane in the process of mass transfer separation typical of PD. In parallel with these achievements, PD techniques have also displayed significant improvements mainly due to the evolution of machines and cyclers. Originally, bottles or containers were used to deliver and drain fluid to and from the peritoneal cavity by gravity using manual techniques. Subsequently, the development of semiautomatic or automatic machines have permitted to deliver an adequate treatment during night-time without the need of patient or care giver intervention. These advances solved the problem of treatment delivery, but other aspects including complications and adherence to prescription could only be managed using magnetic cards containing data from different treatments and brought by the patient at the following routinely planned hospital consultation. Today these limitations have been overcome by the new cycler "HOMECHOICE CLARIA" equipped with SHARESOURCE software featuring a bidirectional communication protocol that allows a full remote patient management (RPM). RPM has demonstrated significant advantages including higher technique survival, reduced rate of complications, and reduced costs in patients undergoing long-term PD.
Remotely biasing, controlling, and monitoring a network routing node based on optically provided signals (2022)

Optical routing typically makes use of nodes located at various places around the optical network. However, many locations can be vulnerable to failure due to the potential for power to be interrupted at optical networks, leading to performance degradation, because the network routing node itself typically requires an electrical DC bias voltage and a control signal. In addition, another key challenge is monitoring the state of the node, especially due to bias and temperature drifts that are common in typical Mach–Zehnder interferometers (MZIs) or nonlinear waveguides such as periodicallypoled- lithium-niobate (PPLN) waveguides. One approach could be to use bidirectional transmission of multiple laser sources over an optical link. Subsequently, (i) arrays of photodiodes that are driven from remote laser sources are used to enable biasing and controlling; (ii) pilot tones are transmitted and their ratios after backpropagation are observed in the transmitter side to monitor the state of operation and adjust the optical powers accordingly. This paper highlights certain architectures for remotely biasing, controlling, and monitoring a network node that lacks local power, which might enable flexible optical networking. These architectures include: (i) an MZI-based optical switch with optically delivered control and data signals as well as a remotely controlled and monitored optical correlator based on either (ii) delay line interferometer (DLI) or (iii) nonlinear wave-mixing in a PPLN waveguide for a QPSK data.
Fast broadband macromodeling technique of sampled time/frequency data using z-domain vector-fitting method (2008)

The vector-fitting algorithm has been used as the main macromodeling tool for approximating frequency domain responses of complex interconnects and electrical packages (Gustavsen, 1999). In this paper, a new methodology is proposed to fit transfer functions of frequency response data obtained from numerical electromagnetic simulation or measured frequency-domain or time-domain response data. This new method, z-domain vector-fitting (ZDVF), is a formulation of vector- fitting method in the z domain; it has an advantage of faster convergence and better numerical stability compared to the s-domain vector-fitting method(VF). The fast convergence of the method reduces the overall macromodel generation time. The accuracy, numerical stability and convergence speed of VF and ZDVF are compared. Examples are provided to demonstrate the advantage of the ZDVF.
Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infection (2021)

T cell immunity is crucial for control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been studied widely on a quantitative level. However, the quality of responses, in particular of CD8<sup>+</sup> T cells, has only been investigated marginally so far. Here, we isolate T cell receptor (TCR) repertoires specific for immunodominant SARS-CoV-2 epitopes restricted to common human Leukocyte antigen (HLA) class I molecules in convalescent individuals. SARS-CoV-2-specific CD8<sup>+</sup> T cells are detected up to 12 months after infection. TCR repertoires are diverse, with heterogeneous functional avidity and cytotoxicity toward virus-infected cells, as demonstrated for TCR-engineered T cells. High TCR functionality correlates with gene signatures that, remarkably, could be retrieved for each epitope:HLA combination analyzed. Overall, our data demonstrate that polyclonal and highly functional CD8<sup>+</sup> TCRs-classic features of protective immunity-are recruited upon mild SARS-CoV-2 infection, providing tools to assess the quality of and potentially restore functional CD8<sup>+</sup> T cell immunity.
In vitro immunosuppressive properties of spergualins to murine T cell response. (1989)

Deoxyspergualin has strong immunosuppressive activity in animals. However, it shows less in vitro immunosuppressive activity at the therapeutic concentration used for in vivo administration. Recently, we reported that there are some technical problems with in vitro experiments. In this report, the effects of spergualins were examined under in vitro conditions which excluded these problems, and compared with cyclosporine A (CYA). Spergualins have suppressive effects on mixed lymphocyte response (MLR) and cytotoxic T lymphocyte induction. Furthermore, interleukin-2 (IL-2) induced proliferation of concanavalin A blasts and CTLL-2 were inhibited at low concentration. However, spergualins have little effect in the early stage of MLR or the mitogen response. These results suggest that spergualins act on the proliferation and differentiation of T cells which respond to growth factors, such as IL-2.
Right Parasternal Lead Placement Increases Eligibility for Subcutaneous Implantable Cardioverter Defibrillator Therapy in Adults With Congenital Heart Disease (2016)

Utilization of both left and right parasternal screening should be used in evaluation of CHD patients for S-ICD eligibility. ECG repolarization characteristics were also identified as novel predictors of screening failure in this group. (Circ J 2016; 80: 1328-1335).
Reconstruction Hidden Objects with Multiple Spackle Images using Microlens Array for Medical Diagnostics (2006)

A new method of seeing objects hidden in scattering medium from multiple speckle images is demonstrated. The entire noisy images from lens array are digitally processed to obtain the desired image of the hidden objects.
A low noise and low cost YIG-oscillator in the frequency range from 4.5 GHz to 12 GHz (1996)

A low noise and low cost YIG-oscillator has been developed. In order to achieve a good phase noise performance it has been simulated employing only the linear scattering parameters of the transistors. Measurements on self built prototype circuits showed a good correspondence with the calculation. The frequency range up to 12 GHz was achieved using only standard Surface-Mounted-Devices (SMD). This grants for a low cost design because the components are not expensive and the circuit is easy to produce.
Bichalcophenes: A concise synthesis of formyl ester‐ and cyano ester‐substituted bithiophenes, bifurans, and furanothiophenes (2010)

Syntheses of new formyl ester- and cyano ester-substituted bithiophenes, bifurans, and furanothiophenes in good yield are described. The key synthetic step uses Stille coupling of appropriately substituted bromo 5-ring heterocycles with stannyl-substituted 5-ring heterocycles.
Implementation of QoS control system with QoE parameters on multimedia services (2010)

In this paper, we propose a method to enhance service user's experience quality when various multimedia services is provided in converged network environment. With the growth of service experience quality interest, multimedia service providers need a method to control experience quality when experience quality is not satisfied by service users. In order to enhance user's experience quality, we design quality control system which can actively control transport QoS parameter according to media quality level. Service and network providers can offer enhanced quality of media service (IPTV, VoD etc) through the proposed system.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha (2018)

Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1α is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Importantly, genetic deletion of IRE1α in iNKT cells reduces cytokine production and protects mice from oxazolone colitis. We therefore propose that an IRE1α-dependent signaling cascade couples constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Deep Reinforcement Learning for DER Cyber-Attack Mitigation (2020)

The increasing penetration of DER with smart-inverter functionality is set to transform the electrical distribution network from a passive system, with fixed injection/consumption, to an active network with hundreds of distributed controllers dynamically modulating their operating setpoints as a function of system conditions. This transition is being achieved through standardization of functionality through grid codes and/or international standards. DER, however, are unique in that they are typically neither owned nor operated by distribution utilities and, therefore, represent a new emerging attack vector for cyber-physical attacks. Within this work we consider deep reinforcement learning as a tool to learn the optimal parameters for the control logic of a set of uncompromised DER units to actively mitigate the effects of a cyber-attack on a subset of network DER.
Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location (2019)

Small RNA profiling in colon cancer tissue revealed novel RNAs associated with MSI and tumor location. We show that Fusobacterium nucleatum are detectable at the RNA-level in colon tissue, and that both Fusobacterium nucleatum and Epstein-Barr virus separate tumor and normal tissue.
Growth Hormone Is Required for Ovarian Follicular Growth (2002)

To analyze the consequences of the absence of GH receptor (GHR) and GH-binding protein (GHBP) on female reproductive function, we used a mouse model in which the GHR/GHBP gene has been disrupted by homologous recombination. The major effect on reproductive function seen in GHR/GHBP knockout (KO) compared with wild-type animals is a dramatic decrease in litter size; this defect is due to a reduction of the ovulation rate. The ovulatory response to exogenous gonadotropin treatment is also 3-fold reduced in GHR/GHBP KO compared with the wild-type ovaries. These results establish that the reduced rate of ovulation is essentially due to an ovarian defect rather than a deficiency in pituitary gonadotropins. The number of follicles per ovary is markedly reduced, although all categories of follicles are represented. Interestingly, the number of healthy follicles from antral and preovulatory stages is dramatically decreased in GHR/GHBP KO in comparison with wild-type follicles. The capacity of follicles to bind LH, FSH, and IGF-I was not diminished. IGF-I treatment using micropumps is not able to rescue either fertility or ovarian responsiveness to exogenous gonadotropins, suggesting that the effect of GH is independent of IGF-I. In conclusion, these results indicate that the reduction of litter size in GHR/GHBP KO mice is the consequence of an alteration of the growth of follicles and suggest that the effects of GH effects on follicular growth are independent of IGF-I.
Three-Dimensional Orientation Mapping and Quantification of Collagen Fibers in a Hormone-Sensitive Breast Tissue Model (2015)

CONFERENCE PAPER (PUBLISHED)"Three-Dimensional Orientation Mapping and Quantification of Collagen Fibers in a Hormone-Sensitive Breast Tissue Model"1 Sep 2015, TISSUE ENGINEERING PART A, 21:S384Co-authors Liu Z, Speroni L, Quinn KP, Sonnenschein C, Soto AM...VIEW MORE INFO
Time-domain and frequency-domain muting schemes for interference co-ordination in LTE heterogeneous networks (2013)

The need for Inter-cell Interference Coordination (ICIC) schemes in LTE heterogeneous networks, is well elucidated in literature [1]. We consider distributed scheduling mechanisms so that multiple base-station vendors can co-exist. Moreover, in legacy LTE networks, fast timescale coordination across base-stations may not be possible due to the inherent backhaul latency. In such a framework, we study the relative performance of frequency-domain and time-domain interference coordination schemes. We also compare the performance of legacy users who are agnostic to the ICIC scheme employed by the network, with users who can intelligently report channel measurements, depending on the param-eters used in the ICIC scheme. Surprisingly, we find that network can efficiently compensate for the legacy user's inadequacy in reporting. Overall, these studies can help the cellular operator to prioritize the strategy for network evolution and decide the timelines to offer advanced user equipment.
Fixed-rate tiling encoders for 2-D constraints (2010)

A new fixed-rate tiling-based coding scheme is presented for two-dimensional (2-D) constraints. The new scheme is shown to improve on the best known rates of formerly published fixed-rate encoders for certain constraints, such as the “no isolated bits” constraint and several 2-D runlength limited (RLL) constraints. Methods of efficient implementation of the suggested scheme are discussed.