gebhart/patrepeval huggingface dataset:
<title>Point-based registration under a similarity transform</title> (2001)

This paper investigates the problem of point-based registration under a similarity transformation. This is a transformation that consists of rotation, translation, and isotropic scaling. There are many applications for registration under a similarity transform. First, the medical applications that usually use rigid-body registration may in some cases be improved by using a scale factor to account for particular types of distortion (for example, drift in gradient strength in MR image volumes). Second, similarity transforms are often used in biometrics to analyze and compare different sets of data. It was shown by Gower in 1971 that the choice of scale factor is independent from the choice of rotation and translation. We use a well-known solution for the rotation and translation parts of the transformation, and concentrate on the problem of choosing the scale factor. We examine three different methods of scaling, one of which is a novel maximum likelihood approach. We derive the target registration error and show the bias for each method. We introduce two different models of fiducial localization error, and we show that for one error model, Gower's method of scaling to minimize the sum of squared distances between corresponding points is also the maximum likelihood solution. Under the other error model, however, maximum likelihood leads to a new method of scaling.
ABT‐122, a Bispecific Dual Variable Domain Immunoglobulin Targeting Tumor Necrosis Factor and Interleukin‐17A, in Patients With Rheumatoid Arthritis With an Inadequate Response to Methotrexate (2018)

Over the 12-week study period, dual inhibition of TNF and IL-17A with ABT-122 produced a safety profile consistent with that of adalimumb used for inhibition of TNF alone. The efficacy of ABT-122 over 12 weeks at dosages of 120 mg every other week or 120 mg every week was not meaningfully differentiated from that of adalimumab at a dosage of 40 mg every other week in patients with RA receiving concomitant methotrexate.
Relationship between Chemosensitivity, Obesity and Blood Pressure in Obstructive Sleep Apnoea (1994)

It has previously been documented that patients with obstructive sleep apnoea (OSA) have an abnormal blood pressure (pressor) response to acute hypoxia when awake. The relationship between hypoxic chemosensitivity and 24 h blood pressure in OSA is not known. Twenty-four hour ambulatory BP (ABP) was measured at 15 min intervals for 24 h using a non-invasive device (Oxford Medilog ABP or Spacelabs 90207 recorder) in 49 men (mean age 51 +/- 9 years), with OSA. The BP response to acute hypoxia was measured either directly (radial arterial line) or indirectly (Finapress) during wakefulness. The pressor response to hypoxia (expressed as the slope of the regression line of mean BP on % fall in arterial oxygen saturation) was compared with the results of the ABP recording, sleep study data and clinical variables. A pressor response to acute hypoxia was present in all patients (mean 1.4 +/- 1.1 mmHg/% delta SaO2, range 0.1-4.5). There was a relationship between the magnitude of the pressor response to hypoxia, severity of sleep apnoea (RDI and minimum SaO2) and central obesity (waist measurement). In contrast, there was no relationship between BP response to hypoxia during wakefulness and 24-h BP. However, increasing obesity and severity of OSA were associated with loss of the normal fall in BP at night. We conclude that enhanced chemosensitivity is common in OSA but there is no demonstrable link between chemosensitivity and mean daytime or night-time ABP.
Fiber optic speed sensor for advanced gas turbine engine control (1991)

A fiber optic speed sensor (FOSS) has been developed, bench tested and rig tested in a real turbine airflow environment. The FOSS employs an innovative design using a pressure tube and fiber optic microbend transducer in order to capture turbine blade pass wake frequency. The blade pass frequency can be converted by a signal processor into turbine rotational speed. The FOSS offers unique potential to meet future requirements for performance (0 to 25 KHz) and environmental tolerance (1200 F temperatures and EMI/EMP threats). Future efforts include development of the signal processor and environmental/durability testing focused on developing reliable, long life operation in the hostile environment of an advanced gas turbine engine.
Survivin as a global target of intrinsic tumor suppression networks (2009)

Despite the constant exposure to genomic insults that may lead to malignancy, cancer is surprisingly a relatively rare occurrence, and this is largely credited to an elaborate network of endogenous tumor suppression. Many effectors of tumor suppression have been identified, and their functions when activated in damaged cells have in large part been elucidated. What is less clear is whether there are common target gene(s) of tumor suppression, whose expression must be ablated in order to block transformation and preserve cellular homeostasis. Fresh experimental evidence suggests that silencing of the mitotic regulator and cell death inhibitor, survivin, is a universal requirement for successful tumor suppression in humans.
Randomized algorithms to update partial singular value decomposition on a hybrid CPU/GPU cluster (2015)

For data analysis, a partial singular value decomposition (SVD) of the sparse matrix representing the data is a powerful tool. However, computing the SVD of a large matrix can take a significant amount of time even on a current high-performance supercomputer. Hence, there is a growing interest in a novel algorithm that can quickly compute the SVD for efficiently processing massive amounts of data that are being generated from many modern applications. To respond to this demand, in this paper, we study randomized algorithms that update the SVD as changes are made to the data, which is often more efficient than recomputing the SVD from scratch. Furthermore, in some applications, recomputing the SVD may not be possible because the original data, for which the SVD has been already computed, is no longer available. Our experimental results with the data sets for the Latent Semantic Indexing and population clustering demonstrate that these randomized algorithms can obtain the desired accuracy of the SVD with a small number of data accesses, and compared to the state-of-the-art updating algorithm, they often require much lower computational and communication costs. Our performance results on a hybrid CPU/GPU cluster show that these randomized algorithms can obtain significant speedups over the state-of-the-art updating algorithm.
The use of a MEMS mirror for closed loop adaptive optics in the human eye (2003)

Summary from only given. Both a MEMS mirror and a liquid crystal spatial light modulator (LC-SLM) have been incorporated into the current Rochester adaptive optical system and are being characterized for use with the human eye.
Discovery of a Substrate Selectivity Motif in Amino Acid Decarboxylases Unveils a Taurine Biosynthesis Pathway in Prokaryotes (2013)

Taurine, the most abundant free amino acid in mammals, with many critical roles such as neuronal development, had so far only been reported to be synthetized in eukaryotes. Taurine is the major product of cysteine metabolism in mammals, and its biosynthetic pathway consists of cysteine dioxygenase and cysteine sulfinic acid decarboxylase (hCSAD). Sequence, structural, and mutational analyses of the structurally and sequentially related hCSAD and human glutamic acid decarboxylase (hGAD) enzymes revealed a three residue substrate recognition motif (X1aa19X2aaX3), within the active site that is responsible for coordinating their respective preferred amino acid substrates. Introduction of the cysteine sulfinic acid (CSA) motif into hGAD (hGAD-S192F/N212S/F214Y) resulted in an enzyme with a >700 fold switch in selectivity toward the decarboxylation of CSA over its preferred substrate, l-glutamic acid. Surprisingly, we found this CSA recognition motif in the genome sequences of several marine bacteria, prompting us to evaluate the catalytic properties of bacterial amino acid decarboxylases that were predicted by sequence motif to decarboxylate CSA but had been annotated as GAD enzymes. We show that CSAD from Synechococcus sp. PCC 7335 specifically decarboxylated CSA and that the bacteria accumulated intracellular taurine. The fact that CSAD homologues exist in certain bacteria and are frequently found in operons containing the recently discovered bacterial cysteine dioxygenases that oxidize l-cysteine to CSA supports the idea that a bona fide bacterial taurine biosynthetic pathway exists in prokaryotes.
Process–structure–property relationships of erodable polymeric biomaterials, I: Poly(desaminotyrosyl arylates) (2002)

Abstract Polymeric biomaterials, especially new compositions, are often tested for biocompatibility, bioerosion rate or cell growth specificity without regard to the morphological structures introduced during materials processing. It will be shown that in addition to the potential influence on biological response, processing induced structure profoundly influences materials properties under bio‐relevant conditions. Using a combinatorial library of erodable Polyarylates, these issues will be explored with emphasis on in‐vivo dimensional stability and mechanical property retention. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Polydispersity and conformation of diluted branched molecules prepared by cross-linking of polystyrene solutions (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolydispersity and conformation of diluted branched molecules prepared by cross-linking of polystyrene solutionsFrancois Schosseler and Ludwik LeiblerCite this: Macromolecules 1985, 18, 3, 398–403Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ma00145a017https://doi.org/10.1021/ma00145a017research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Samarium‐Mediated Reactions (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dual Capillary-based Vibrating Sharp-edge Spray Ionization (cVSSI) with On-line Solution-phase Hydrogen/Deuterium Exchange for Distinguishing Carbohydrates Isomers (2022)

In-droplet hydrogen-deuterium exchange (HDX) combined with mass spectrometry (MS) has been used to characterize the reactivities of monosaccharide (3 pairs), disaccharide (4 pairs), and glycan (1 pair) isomer compounds. To accomplish in-droplet HDX, capillary vibrating sharp-edge spray ionization (cVSSI) employing a dual emitter tip setup is utilized. The solution-phase HDX technique is shown to be extremely reproducible for these measurements such that several different isomer sets can be distinguished by their unique isotopic distributions in the mass spectrum. The results are discussed in light of their applicability toward identifying metabolite compounds in complex metabolomics mixtures.
A Generalized Proportionate-Type Normalized Subband Adaptive Filter (2021)

We show that a new design criterion, i.e., the least squares on subband errors regularized by a weighted norm, can be used to generalize the proportionate-type normalized subband adaptive filtering (PtNSAF) framework. The new criterion directly penalizes subband errors and includes a sparsity penalty term which is minimized using the damped regularized Newton's method. The impact of the proposed generalized PtNSAF (GPtNSAF) is studied for the system identification problem via computer simulations. Specifically, we study the effects of using different numbers of subbands and various sparsity penalty terms for quasi-sparse, sparse, and dispersive systems. The results show that the benefit of increasing the number of subbands is larger than promoting sparsity of the estimated filter coefficients when the target system is quasi-sparse or dispersive. On the other hand, for sparse target systems, promoting sparsity becomes more important. More importantly, the two aspects provide complementary and additive benefits to the GPtNSAF for speeding up convergence.
Prediction of the failure interval with maximum power based on the remaining useful life distribution (2015)

Prognosis of the Remaining Useful Life (RUL) of a unit or system plays an important role in system reliability analysis and maintenance decision making. One key aspect of the RUL prognosis is the construction of the best prediction interval for failure occurrence. The interval should have a reasonable length and yield the best prediction power. In current practice, the center-based interval and traditional confidence interval are widely used. Although both are easy to construct, they do not provide the best prediction performance. In this article, we propose a new scheme, the Maximum Power Interval (MPI), for estimating the interval with maximum prediction power. The MPI guarantees the best prediction power under a given interval length. Some technical challenges involved in the MPI method were resolved using the maximum entropy principle and truncation method. A numerical simulation study confirmed that the MPI has better prediction power than other prediction intervals. A case study using a real industry data set was conducted to illustrate the capability of the MPI method.
All-optical data format conversions and reconversions between the wavelength and time domains for dynamically reconfigurable WDM networks (1996)

We demonstrate all-optical error-free 2 Gb/s data format conversions and reconversions between the wavelength and time domains. Conversion between these two domains is accomplished by performing single-stage TDM-to-WDM and WDM-to-TDM conversions. We also perform the function of converting back all-optically to the original domain by performing both WDM-to-TDM-to-WDM and TDM-to-WDM-to-TDM reconversions. All conversions and reconversions are realized by using the cross gain compression mechanism inherent in semiconductor optical amplifiers (SOA's). We first demonstrate our TDM-to-WDM converter by simultaneously time demultiplexing and wavelength shifting a four-channel 2 Gb/s TDM data stream into four 500 Mb/s WDM channels. Moreover, we extend this single-stage approach by demonstrating a two-stage TDM-to-WDM converter consisting of two cascaded single-stage TDM-to-WDM modules. This two-stage converter selectively time demultiplexes and wavelength shifts a four-channel 2 Gb/s TDM data stream into two 500 Mb/s WDM channels after the second stage. Furthermore, we demonstrate a WDM-to-TDM converter by simultaneously time multiplexing and wavelength shifting the data from two 1 Gb/s WDM channels into one 2 Gb/s TDM signal. Finally, we demonstrate reconversion between the wavelength and time domains for two channels by performing both WDM-to-TDM-to-WDM and then TDM-to-WDM-to-TDM reconversions. In order to demonstrate system robustness, we use 80 km of fiber and three EDFA's between the conversion and reconversion stages. We show that reconverting back to the TDM data format requires an interstage WDM channel wavelength range less than /spl sim/4 nm, due to the power penalty induced by the interstage relative phase shift between the channels. This constraint limits the operation of the TDM-to-WDM-to-TDM reconverter to data rates up to 10 Gb/s and interstage distances to /spl sim/100 km. All demonstrated conversion and reconversion processes are accomplished with low power penalties. These conversion and reconversion schemes could be useful in WDM switching nodes and may serve as key building blocks for all-optical WDM networks.
Modeling of Hi-Q Embedded Inductors for RF-SOP Applications (2006)

A new broadband nine-element single-stage model is developed for the high-Q spiral inductor buried into the organic laminate package substrate. The technique utilizes only one RLC resonator incorporated in modified T equivalent circuit to accurate characterize high-frequency effects such as skin, proximate, and fringing effects, and that led to the model more compact. Parameter extraction of model is used analytical all-mathematical formulations to evaluate frequency-independent elements. This enables the modeling procedure effectively integrated in SPICE-compatible simulators feasible and facile for efficient design of RFIC modules. The proposed model has been verified using embedded inductor in a 4-layer BT laminate, one of today's most popular package substrate. Good agreement between measurements and modeling results over the whole interesting frequency regime has been shown to demonstrate the validity of proposed method
Blistering1 Modulates Penicillium expansum Virulence Via Vesicle-mediated Protein Secretion (2019)

The blue mold fungus, <i>Penicillium expansum,</i> is a postharvest apple pathogen that contributes to food waste by rotting fruit and by producing harmful mycotoxins (<i>e.g.</i> patulin). To identify genes controlling pathogen virulence, a random T-DNA insertional library was created from wild-type <i>P. expansum</i> strain R19. One transformant, T625, had reduced virulence in apples, blistered mycelial hyphae, and a T-DNA insertion that abolished transcription of the single copy locus in which it was inserted. The gene, <i>Blistering1,</i> encodes a protein with a DnaJ domain, but otherwise has little homology outside the Aspergillaceae, a family of fungi known for producing antibiotics, mycotoxins, and cheese. Because protein secretion is critical for these processes and for host infection, mass spectrometry was used to monitor proteins secreted into liquid media during fungal growth. T625 failed to secrete a set of enzymes that degrade plant cell walls, along with ones that synthesize the three final biosynthetic steps of patulin. Consequently, the culture broth of T625 had significantly reduced capacity to degrade apple tissue and contained 30 times less patulin. Quantitative mass spectrometry of 3,282 mycelial proteins revealed that T625 had altered cellular networks controlling protein processing in the endoplasmic reticulum, protein export, vesicle-mediated transport, and endocytosis. T625 also had reduced proteins controlling mRNA surveillance and RNA processing. Transmission electron microscopy of hyphal cross sections confirmed that T625 formed abnormally enlarged endosomes or vacuoles. These data reveal that <i>Blistering1</i> affects internal and external protein processing involving vesicle-mediated transport in a family of fungi with medical, commercial, and agricultural importance.
Toward effectively generating environment maps (2003)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Decarb/Desal: Separation of Carbon Dioxide from Flue Gas with Simultaneous Fresh Water Production (2009)

If fossil fuels continue to be a major part of the world's energy supply, effective means must be developed to deal with the carbon emissions. Geologic sequestration of supercritical CO{sub 2} is expected to play a major role in mitigating this problem. Separating carbon dioxide from other gases is the most costly aspect of schemes for geologic sequestration. That cost is driven by the complexity and energy intensity of current chemical-stripping methods for separating carbon dioxide. Our experience in water treatment technology indicated that an entirely new approach could be developed, taking advantage of water's propensity to separate gases that ionize in water (like CO{sub 2}) from those that do not (like N{sub 2}). Even though water-based systems might not have the extreme selectivity of chemicals like substituted amines used in industrial systems today, they have the potential to tolerate NO{sub x}, SO{sub x}, and particulates while also producing clean drinking water as a valuable byproduct. Lower capital cost, broader range of applicability, environmental friendliness, and revenue from a second product stream give this approach the potential to significantly expand the worldwide application of carbon separation for geologic sequestration. Here we report results for separation of CO{sub 2} from flue gas by two methods that simultaneously separate carbon dioxide and fresh water: ionic pumping of carbonate ions dissolved in water, and thermal distillation. The ion pumping method dramatically increases dissolved carbonate ion in solution and hence the overlying vapor pressure of CO{sub 2} gas, allowing its removal as a pure gas. We have used two common water treatment methods to drive the ion pumping approach, reverse osmosis and electrodialysis to produce pure CO{sub 2}. This novel approach to increasing the concentration of the extracted gas permits new approaches to treating flue gas, because the slightly basic water used as the extraction medium is impervious to trace acid gases that destroy existing solvents, and no pre-separation is necessary. Thermal distillation uses boiling water to steam strip solid sorbents - the steam is recovered as fresh water. We anticipate that our method will compete favorably with current chemical stripping systems used for CO{sub 2} separation at power plants, which incur a 35% energy penalty. Thus we expect to offer a dramatically improved solution for removing carbon from hydrocarbon combustion. Our method can be demonstrated on small sources, which will enable us to conduct the demonstrations required to build confidence in the method. If successful, we will be in a position to advance a follow-on proposal for a demonstration at the 10-MW scale.