gebhart/patrepeval huggingface dataset:
Bibliographical essays for chapters (1987)

This bibliographical essay presents a list of titles that help the reader to understand the concept of Chinese political problems. The essay talks about the reunification of China, establishment and consolidation of the new regime, China's economic development, and Chinese education. Cultural Revolution sources that appeared in 1966-69 are of two types: highly polemic "revelations" about the alleged crimes of various leaders in the pre-1966 period. The official Chinese newspapers, journals, and the occasional compendia of state laws comprise the major source materials. The easily accessible route to the Chinese originals lies through the clipping file service of the Union Research Institute, which ceased to exist in 1983. The essay also talks about the party and the intellectuals, foreign relations, and the Sino-Soviet split. The relative recentness of Sino-Soviet split precludes access to standard US Department of State sources, while the secretiveness of the Soviet Union and the People's Republic of China limits the value of Soviet and Chinese materials.
Process analysis of a reactor‐separator system: Enzymic degradation of polymeric substrates (2005)

Abstract The analysis deals with an integrated system in which enzymic de‐polymerization of a macromolecular substrate and concomitant separation of the reaction products take place. The enzyme is immobilized within a packed‐bed reactor and products are separated by ultrafiltration. A compartmental model was set up and used to simulate the performance of the system in terms of yield, purity, and productivity of the monomer obtained, and as a function of the system operating mode (batch or continuous), recirculation ratio, enzyme mode of action (preferred attack or exo‐type), and initial polymer concentration. Results, calculated using the analytical model, are in good agreement with our experimental findings concerning the depolymerization of inulin by exo‐inulinase. Future applications include engineering design of the system and optimization of its operational parameters.
Magnetic multilayer structure (2023)

A mechanism is provided for an integrated laminated magnetic device. A substrate and a multilayer stack structure form the device. The multilayer stack structure includes alternating magnetic layers and diode structures formed on the substrate. Each magnetic layer in the multilayer stack structure is separated from another magnetic layer in the multilayer stack structure by a diode structure.
Kernel Regression for Energy-Optimal Control of Fully Electric Vehicles (2021)

This paper presents a control algorithm for electric vehicles (EVs) with multiple motors. The control algorithm minimizes the EV's energy usage by optimizing the efficiency of its electric motors. The degrees of freedom exploited by the control algorithm are the torque-split ratio between multiple motors, the transmission gear ratio, as well as the velocity profile of the EV. The algorithm uses kernel regression to learn a pseudo-convex cost function for optimal control from tabulated data of the electric motors' efficiency maps. The main advantages of the algorithm are its real-time feasibility due to the pseudo-convex shape and its flexible approximation capabilities. A simulation study shows how an EV with multiple but different motors and a torque-split controller can efficiently exploit the range of operation of the individual motors. The proposed algorithm achieves energy savings of up to 20% and 40% for the US06 and Urban Dynamometer Driving Schedule (UDDS), respectively, by leveraging the strengths of the different electric motors. Finally, we show that the energy-optimal velocity profile varies for different EV specifications as a result of their motor efficiencies. In particular, compared to a profile with constant acceleration, the proposed kernel regression algorithm achieves energy savings of up to 13%.
STRUCTURE‐ACTIVITY RELATIONSHIP OF PORPHINES FOR PHOTOINACTIVATION OF BACTERIA (1995)

The antibacterial photodynamic effects of uncharged (o-tetrahydroxyphenyl porphine [THPP], m-THPP and p-THPP), cationic (5,10,15,20-tetra[4-N-methylpyridyl]porphine [TMPyP]) and anionic (5,10,15,20-tetra[4-sulfonatophenyl porphine] [TPPS4]) porphines on Staphylococcus aureus and Escherichia coli bacteria inactivation were examined. The results show that uncharged porphines provoked antibacterial photodynamic activity on S. aureus, and also on E. coli in the presence of the membrane-disorganizing peptide polymixin B nonapeptide (PMNP). The TMPyP compound was highly photoactive toward gram-positive bacteria but only marginally effective on gram-negative cells, whereas TPPS4 showed no activity on either gram-positive or gram-negative bacteria. The photoactivity of TMPyP is due to the electrostatic attraction between the positively charged sensitizer molecule and the negatively charged membrane of the gram-positive target cells. For TPPS4, the inactivity toward gram-positive bacteria is due to electrostatic repulsion between the charged sensitizer molecule and the cell membrane. For gram-negative bacteria, the inactivity is conceivably due to preferential (electrostatic) binding to the positively charged PMNP, which is an adjuvant for membrane disorganization, but has no effect on cell viability. For hydrophobic sensitizers, the photoactivity depends on the state of aggregation. The extent of deaggregation of the different THPP isomers was determined by fluorescence measurements of bound sensitizers and could be positively correlated with their photoinactivation capacity. We conclude that the structure-activity relationships of these porphines are affected by their net charge and by aggregation.
An explorative survey of pharmacy students` and practicing pharmacists` perception towards medical technology education in the Nordic and Baltic countries (2015)

ISBN 978-9955-15-410-5.
Genetic variants linked to education predict longevity (2016)

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n<sub>deaths</sub> = 79,702) and ∼2.4% lower risk for fathers (total n<sub>deaths</sub> = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
Procuring Universal Service: Putting Auction Theory to Work (1997)

United States and the kinds of solutions that had been previously proposed. Similar issues arise in every economically developed country, particularly in democracies, as well as in some other industries, such as the electrical power industry. The third part shows how Vickrey&amp;apos;s ideas and those of his intellectual descendants can be and are being used to generate new and superior alternatives for dealing with these issues. The final part points out some of the remaining limitations of the analysis. Vickrey and Auction Theory Before turning our attention to the details of Vickrey&amp;apos;s analyses of auctions, let us pause for a moment to admire the remarkable concept behind them. Before Vickrey&amp;apos;s work, economic theorizing about markets abstracted from the detailed rules that determine who trades how much with whom and at what price. In the writings of classical economists like Smith and Marshall and neoclassical Nobel laureates like Samuelson, Arrow, Hicks and Debreu, analysis focused on the
Macrofragments et microfragments dans un segment de la grille de programmes de la chaîne publique France 5 (2011)

http://www.unicaen.fr/colloques/cnriut2011/spip.php?rubrique2
A Pt(0) complex with cyclic (alkyl)(amino)silylene and 1,3-divinyl-1,1,3,3-tetramethyldisiloxane ligands: synthesis, molecular structure, and catalytic hydrosilylation activity (2017)

A platinum(0) complex bearing a cyclic (alkyl)(amino)silylene and a 1,3-divinyl-1,1,3,3-tetramethyldisiloxane (DVTMS) was synthesized and isolated in the form of colorless crystals. The single-crystal X-ray diffraction analysis of this complex in combination with theoretical calculations indicated that the Pt→Si π-back-donation in this complex is weaker than that in the corresponding cyclic-dialkylsilylene-ligated Pt complex. The performance of this complex in the catalytic hydrosilylation of (Me<sub>3</sub>SiO)<sub>2</sub>MeSi-H with various terminal alkenes that contain functional groups was comparable to that of the corresponding cyclic dialkylsilylene/DVTMS Pt(0) complex.
Optical properties of NTN-FSC-LCD and ECB cells with the doping of nanoparticles (2013)

The doping of nanoparticles of PγCyD-ZrO2 and those hydrophobic SiO2 and TiO2 into brings tremendous changes in their optical properties such as the reduction of birefringence, the creation of an optical homogenizing effect and the enhancement of the performance of FSC-LCD that produces a large value of Luminance Efficiency; this paper reports these novel optical effects in LCDs.
Topology of the electrostatic potential in the analysis of molecular reactivities and hydrogen bonds (2008)

The Maximum Entropy Method (MEM) is applied to lowtemperature single crystal x-ray diffraction data of amino acids and peptides. The resulting electron density maps are analyzed according to Bader's Atoms in Molecules theory (Bader, 1994) towards the determination of the electron density and its Laplacian at bond critical points (BCPs). Energy densities at BCPs are calculated according to Abramov (1997), employing the local virial theorem. Geometrical, topological and energetic properties of 52 hydrogen bonds are studied. The electron densities, their principal curvatures and the energy densities at BCPs are found to depend systematically on the distance between hydrogen and acceptor atom. These relations appear different from the corresponding relations as described by Espinosa et al. (1999) for multipole densities. MEM electron densities at the BCPs of hydrogen bonds are higher than the multipole densities. The difference between MEM and multipole densities is more pronounced for stronger hydrogen bonds. The contribution of the prior density (overlapping spherical atomic electron densities) to the MEM density is studied. The prior density seems to contribute a large part to topological and energetic properties at BCPs of hydrogen bonds. However, the properties at BCPs of covalent bonds of MEM densities differ significantly from the prior. Thus, for research into chemical bonds an experimental electron density should not be substituted by a promolecule.
Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1 (2022)

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting PBD based on acyclic phosphopeptide PMQSpTPL. The inhibitory activities of <b>16e</b> on Plk1-PBD is >30-fold higher than those of PMQSpTPL. Both <b>16a</b> and <b>16e</b> possess excellent selectivity for Plk1-PBD over Plk2/3-PBD. Analysis of the cocrystal structure of Plk1-PBD in complex with <b>16a</b> reveals that the 3-(trifluoromethyl)benzoyl group in <b>16a</b> interacts with Arg516 through a π-stacking interaction. This π-stacking interaction, which has not been reported previously, provides insight into the design of novel and potent Plk1-PBD inhibitors. Furthermore, <b>16h</b>, a PEGlyated macrocyclic phosphopeptide derivative, induces Plk1 delocalization and mitotic failure in HeLa cells. Also, the number of phospho-H3-positive cells in a zebrafish embryo increases in proportion to the amount of <b>16a</b>. Collectively, the novel macrocyclic peptidomimetics should serve as valuable templates for the design of potent and novel Plk1-PBD inhibitors.
Synthesis and Stereoselective CC Bond‐forming Reactions of Peptide Aldehydes (1996)

Abstract The reaction of the activated form of N ‐protected amino acids 6 and 10 or peptides 14 and 18 with chiral amino alcohols derived from the corresponding α‐amino acids affords peptide alcohols which can be oxidized under Swern conditions to produce the corresponding peptide aldehydes 9, 12, 16 and 20 . The rational synthesis of diastereomeric di‐ and tripeptide aldehydes, e.g., ( S,S )‐ or ( R,S )‐dipeptides as well as ( S,S,S )‐ or ( R,S,S )‐tripeptides is possible by proper choice of the respective building blocks [( S )‐ versus ( R )‐amino acids]. The compounds can be prepared without any undesired α‐epimerization. However, the long‐term configurational stability depends upon the configuration at the remote stereogenic center, e.g., ( R,S )‐dipeptide aldehydes epimerize faster than the ( S,S ) diastereomers. Di‐ and tripeptide aldehydes 9, 12, 16 and 20 undergo chelation‐controlled Grignard‐type additions with Me 2 CuLi that involve little or no undesired α‐epimerization. The ( S,S )‐ and ( R,S )‐dipeptide aldehydes 9 and 12 undergo chelation‐controlled pinacol reactions induced by the low‐valent vanadium reagent [V 2 Cl 3 (THF) 6 ] 2 [Zn 2 Cl 6 ]. The major products in both cases are the corresponding C 2 ‐symmetric diols 33 and 36 , respectively, which are of interest as potential HIV‐protease inhibitors. The degree of stereoselectivity is significantly higher in the case of the ( S,S )‐dipeptide aldehydes relative to the ( R,S ) analogs, an observation which can be explained on the basis of three‐point binding of the peptides to vanadium.
Trastuzumab deruxtecan in recurrent uterine serous carcinoma resistant to trastuzmab based-chemotherapy (2023)

T-DXd may present a new treatment option for chemotherapy-resistant uterine serous carcinoma.
Several new lower bounds for football pool systems. (1998)

We derive several new lower bounds on the size of ternary covering codes of lengths 6, 7 and 8 and with covering radii 2 or 3. 1 Introduction Ternary covering code C of length n and radius R is a collection of ternary vectors of length n possessing the property that every ternary vector of length n differs from at least one codeword in at most R coordinates. We wish to minimize the size of C. The search for ternary covering codes attracted a big deal of attention due to its equivalence to constructing systems for football pools. A survey of what is known on the problem can be found in [8, 7, 11]. Along with constructing such codes, lower bounds on their size are extensively studied [2, 4, 5, 6, 9, 12, 13]. The known lower bounds give reasonably good results in cases when R is relatively small in comparison with n. In the paper we present an approach giving several better lower bounds in some situations when R is relatively big. Let K 3 (n; R) be the minimal size of a ternary code of l...
Experimental demonstration of intermodal nonlinear effects between full vectorial modes in a few moded fiber (2013)

We experimentally investigate intermodal nonlinear interactions, such as Raman scattering and four wave mixing. The fiber used is a specially designed few moded fiber, which splits the degeneracy of the first mode group, leading to stable propagation of the two full vectorial modes, TM01 and TE01. For the Raman experiments pumping occur in either the fundamental mode or the two full vectorial modes, whereas the signal is in the fundamental mode. In all three experiments approximately 40 dB of gain is achieved using 307 W of pump peak power. When pumping in either of the full vectorial modes four wave mixing is observed.
<title>Multilayer write-once media with Te-O-Pd films utilizing violet laser</title> (2002)

Multi-layer write-once optical disks with tellurium suboxide palladium-doped phase-change recording films were designed and adopted to read/write utilizing a violet laser. A dual- layer medium showed carrier to noise ratios (CNRs) of more than 50 dB within a laser power of 7 mW at a linear velocity of 5 m/s in each the condition of numerical aperture (NA) equals 0.65 and NA equals 0.85, which corresponds to a recording capacity of 27 GB and 45 GB on a dual-layer disk of (phi) 120 mm in diameter, respectively. Furthermore, a quadruple-layer medium showed CNRs of more than 48 dB within a laser power of 12 mW at a linear velocity of 5 m/s in the condition of NA equals 0.85, which corresponds to a recording capacity of 90 GB on a quadruple-layer disk of (phi) 120 mm.
Human Erythrocyte Antigens (1987)

Human erythrocyte membrane proteins express antigens which serve as markers for erythroid differentiation as well as targets for human blood group alloantibodies. We have produced and characterized a new panel of five monoclonal antibodies to erythrocyte membrane proteins. Three monoclonal antibodies (E3, E4, E5) were specific for erythrocyte glycophorins. One antibody (E3) identified the sialoglycoprotein alpha and beta homologous regions proximal to the plasma membrane, a second antibody (E4) was specific for sialoglycoprotein alpha, while a third (E5) was a sialoglycoprotein-beta-specific antibody. Two antibodies (E6 and TE10) to the 65,000-dalton chymotrypsin cleavage product of band 3 were also produced. These antibodies constitute a new panel of probes for investigation of normal erythroid differentiation, erythroleukemia, and the expression of normal and anomalous blood group antigens.
SELECTION OF PERFORMANCE LEVELS FOR LONGITUDINAL BARRIERS (1986)

There is a demand within the highway community for multi-service level safety features, including traffic barriers. The need has become more acute in recent years as revenues decline and as the demand for highway safety increases. This paper examines an array of longitudinal traffic barriers, having varying service or performance levels, to identify traffic conditions for which the respective barriers would have applications. A benefit/cost procedure was used in the analysis. The end result was a tentative set of suggested barrier performance limits that have application for practically all possible traffic conditions.
Petroleum geostatistics for nongeostatisticians (2000)

This is the first of two articles intended to describe petroleum geostatistics for the nongeostatistician. There are many misconceptions about geostatistics, what it is, and what it can or can't do for the petroleum industry.
Synthesis of the Entomopathogenic Fungus Metabolites Militarinone C and Fumosorinone A (2018)

Militarinone C and fumosorinone A, 3-oligoenoyltetramic acids produced by insect pathogenic fungi, were synthesized for the first time. The pyrrolidine-2,4-dione ring was closed through a late-stage Dieckmann condensation of N-(β-ketoacyl) derivatives of tyrosine, obtained by its acylation with either thioesters or Meldrum's acid derivatives bearing the all- trans-polyene side chain. The latter was built up from ( S)-citronellol via an Evans methylation and Wittig or HWE olefinations.
Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor. (2012)

Abstract Abstract 2218 The purinergic P2X7 receptor contributes to thrombosis by promoting tissue factor (TF) activation and the release of prothrombotic microparticles (MP). On primed macrophages, P2X7 stimulation induces the procoagulant activity of cell surface TF and the release of MP that carry TF, integrin β1 and protein disulfide isomerase (PDI). The generation of TF+ MP is dependent on extracellular thiol-disulfide exchange, but intermediates leading to MP generation downstream of P2X7 signaling are incompletely defined. Tracking of cell surface TF by confocal microscopy shows that constitutive internalization of TF is prevented by P2X7 activation. In non-stimulated cells, inhibition of dynamin-dependent endocytosis retains TF on the cell surface, rapidly upregulates TF activity, and releases procoagulant MP carrying TF and integrin β1. Integrin recycling is dependent on the small GTPase ARF6 that is found incorporated into MP released when internalization is blocked. In contrast, activation of P2X7 releases ARF6 into the MP-depleted supernatant rather than associated with MP. Decreased ARF6 GTP loading in P2X7-stimulated cells and additional data in integrin α4 S988A mutant mice with reduced ARF6 activity support the conclusion that P2X7 interrupts constitutive ARF6 recycling to increase cell surface availability of TF-integrin complexes for incorporation into MP. Confocal imaging shows that P2X7 stimulation promotes filopodia formation and the peripheral transport of TF to the tips of filipodia. Proteomics identifies γ-actin as a thiol-regulated MP protein that is released by P2X7 signaling. We show that specific inhibition of thioredoxin reductase attenuates P2X7-induced actin remodeling and filopodia formation, the generation of highly procoagulant MP carrying γ-actin and PDI, and the increased availability of extracellular thioredoxin and free thiols. Importantly, inhibition of thioredoxin reductase also prevented the processing and release of the pro-inflammatory cytokine IL1β. Thus, the thioredoxin reductase system is a crucial intermediate downstream of P2X7 activation that may couple coagulation and inflammation in cardiovascular diseases. Disclosures: No relevant conflicts of interest to declare.
Diffusion of Water in Nafion Using Time-Resolved Fourier Transform Infrared−Attenuated Total Reflectance Spectroscopy (2009)

Hydrogen fuel cells are attractive alternative power sources for applications such as transportation; however, fuel cell performance is a strong function of water equilibrium content and water sorption and desorption kinetics in polymer electrolyte membranes (e.g., Nafion). Although similar water sorption isotherms for Nafion have been reproduced in many laboratories, reported diffusion coefficients of water in Nafion vary by 4 orders of magnitude. In this study, sorption and desorption dynamics of water vapor in Nafion were measured as a function of water vapor activity and flow rate using time-resolved Fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy. Both integral and differential experiments were performed, where integral experiments consisted of increasing the vapor activity from 0% RH to one of five values (22, 43, 56, 80, or 100% RH), while in differential experiments the activity was sequentially increased in smaller steps from 0 to 22 to 43 to 56 to 80 to 100% RH. For integral experiments, non-Fickian behavior was observed at both low and high vapor activities, while Fickian behavior was observed at moderate vapor activities. For differential experiments, Fickian behavior was observed at all vapor activities except at low vapor activities (0-22% RH). Sorption kinetics was found to be a function of flow rate, where mass transfer resistance at the vapor/polymer interface was significant at low flow rates but was insignificant at high flow rates. Accurate sorption and desorption diffusion coefficients were calculated in this study (measured at high flow rates with no mass transfer resistance) and were similar, on the order of 10(-7) cm(2)/s, and weak functions of water vapor activity.
Magneto-fluorescent core-shell supernanoparticles (2014)

Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms *Correspondence to: