gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of Light‐Emitting Conjugated Polymers for Applications in Electroluminescent Devices (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetic Microparticles@UiO-67 Core-Shell Composites as a Novel Stationary Phase for High Performance Liquid Chromatography (2014)

Metal-organic framework UiO-67 was explored as a novel stationary phase for high performance liquid chromatography (HPLC). UiO-67 was, for the first time, homogeneously coated on carboxyl functionalized magnetic silica microparticles at low temperature (45 °C) by using a recently introduced liquid phase epitaxy (LPE) process. HPLC runs using the synthesized core-shell microparticles as stationary phase showed baseline separation for three phenol derivatives, applying gradient elution using acetonitrile and water as mobile phase. It also showed that UiO-67 has the largest affinity for 2,6-dichlorophenol among the phenol derivatives tested. The comparison of core-shell microparticles with 20 and 55 layers, respectively, of UiO-67 grown on the magnetic silica core proof that the UiO-67 shell determines separation behavior. Therefore, the use of UiO-67 core-shell microparticles as a stationary phase combines the advantages of a thin, homogenous MOF shell showing fast kinetics and good separation efficiency with the advantages of spherical silica microparticle cores offering high mechanical robustness and moderate pressure drop.
Cerebrospinal Fluid (1,3)-β- d -Glucan Detection as an Aid for Diagnosis of Iatrogenic Fungal Meningitis (2013)

This case series highlights our experience with use of the Fungitell assay for quantifying (1,3)-β-d-glucan in cerebrospinal fluid during the current U.S. outbreak of fungal meningitis related to contaminated methylprednisolone acetate. This test may prove a useful adjunct in diagnosis and management of exposed patients.
Multi-user data sharing in radar sensor networks (2007)

In this paper, we focus on a network of rich sensors that are geographically distributed and argue that the design of such networks poses very different challenges from traditional mote-class sensor network design. We identify the need to handle the diverse requirements of multiple users to be a major design challenge, and propose a utility-driven approach to maximize data sharing across users while judiciously using limited network and computational resources. Our utility-driven architecture addresses three key challenges for such rich multi-user sensor networks: how to define utility functions for networks with data sharing among end-users, how to compress and prioritize data transmissions according to its importance to end-users, and how to gracefully degrade end-user utility in the presence of bandwidth fluctuations. We instantiate this architecture in the context of geographically distributed wireless radar sensor networks for weather, and present results from an implementation of our system on a multi-hop wireless mesh network that uses real radar data with real end-user applications. Our results demonstrate that our progressive compression and transmission approach achieves an order of magnitude improvement in application utility over existing utility-agnostic non-progressive approaches, while also scaling better with the number of nodes in the network.
On‐Chip Synthesis and Label‐Free Assays of Oligosaccharide Arrays (2008)

Mit Zuckerguss: Eine neue Strategie für die Festphasensynthese von Oligosacchariden mit direkter SAMDI-TOF-massenspektrometrischer Detektion (siehe Schema) umfasst die Synthese eines Ligandenarrays auf einem Chip, eine markierungsfreie Detektion und die direkte Anwendung eines Enzymassays. (SAMDI-TOF: self-assembled monolayers for matrix-assisted laser desorption-ionization time-of-flight.) Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z704998_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Development of functional cytokine mutants bymolecular evolution and drug delivery technology (2011)

近年のゲノミクス・プロテオミクス研究の進展により，さまざまな疾患に関与するタンパク質が同定されつつあり，それらタンパク質の医薬品化に期待が寄せられている．しかし，タンパク質は一般に体内安定性にきわめて乏しいため，治療効果を得るためには大量頻回投与が必要となる．とりわけサイトカインは，さまざまな細胞の複数種類のレセプターを介して多様なin vivo生理活性を示すため，目的とする治療作用のみならず副作用の原因となる他の作用までをも同時に発揮してしまう．そのため，タンパク質の臨床応用は制限され，医薬品化に成功した例は限られている．従って，疾患プロテオミクス研究の成果を有効活用した次世代のバイオ創薬研究を成功に導くためには，これらタンパク質固有の問題点を克服しうる創薬テクノロジー，すなわちタンパク療法の最適化に適うDrug Delivery System（DDS）の確立が不可欠である．本稿では，筆者らが確立してきたDDS技術， (1) レセプター親和性・特異性などが高く医薬価値に優れた機能性人工タンパク質を迅速創製できるタンパク質分子進化技術，および， (2) タンパク質の生体内安定性を向上させ，かつ目的治療作用の選択的発現能を付与できる高分子バイオコンジュゲーション技術を利用した次世代型バイオ医薬の開発研究について紹介する．
ChemInform Abstract: Substituted 2,2′:5′,2′′:5′′,2′′′:5′′′,2′′′′:5′′′′,2′′′′′:5′′′′′,2′′′′′′ :5′′′′′′,2′′′′′′′:5′′′′′′′,2′′′′′′′′:5′′′′′′′′,2′′′′′′′′′: 5′′′′′′′′′, 2′′′′′′′′′′‐Undecithiophenes: The Longest Characterized Oligothiophenes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure 6 from <i>TMPRSS2-ERG</i> Status Is Not Prognostic Following Prostate Cancer Radiotherapy: Implications for Fusion Status and DSB Repair (2023)

&lt;p&gt;Supplementary Figure 6 - PDF file 113K, Univariate Kaplan-Meier plots of bRFR versus time to recurrence for the Memorial Sloan Kettering Prostate Cancer cohort of patients who underwent surgery with differential TMPRSS2-ERG fusion status based on array Comparative Genome Hybridization (aCGH)&lt;/p&gt;
Clathrate hydrates in interstellar environment (2019)

Clathrate hydrates (CHs) are ubiquitous in earth under high-pressure conditions, but their existence in the interstellar medium (ISM) remains unknown. Here, we report experimental observations of the formation of methane and carbon dioxide hydrates in an environment analogous to ISM. Thermal treatment of solid methane and carbon dioxide-water mixture in ultrahigh vacuum of the order of 10<sup>-10</sup> mbar for extended periods led to the formation of CHs at 30 and 10 K, respectively. High molecular mobility and H bonding play important roles in the entrapment of gases in the in situ formed 5<sup>12</sup> CH cages. This finding implies that CHs can exist in extreme low-pressure environments present in the ISM. These hydrates in ISM, subjected to various chemical processes, may act as sources for relevant prebiotic molecules.
Correlation between the mechanical properties and the homogeneity of some photopolymerized acrylic/methacrylic networks1 (1996)

Proton T1ρ data obtained by CP/MAS solid-state 13C NMR at 100.56 MHz for different polyacrylate networks were correlated with their mechanical properties in order to determine the best mixture in terms of stress-at-break (σ), Young's modulus of elasticity (Y), and homogeneity of the monomers that are forming the solid network. The mixtures were formed by the photopolymerization of 40% trimethylolpropane triacrylate (TMPTA), 40% dipentaerythritol pentaacrylate (DPHPA), and 20% of a monomer from a series of poly(ethylene glycol) and poly(ethylene) dimethacrylate. Proton T1ρ's in networks were not quite averaged to a single value by spin diffusion as in polymer blends, indicating extensive intermixing of TMPTA and DPHPA in forming the network, but with phase separation between the dimethacrylate homopolymer and the rest of the network that is dependent on the laser power. The stress-at-break and the Young's modulus of elasticity were determined for each of the mixtures at different values of the laser power used for the polymerization. © 1996 John Wiley & Sons, Inc.
A Pseudo-distance for Shape Priors in Level Set Segmentation (2003)

We study the question of integrating prior shape knowledge into level set based segmentation methods. In particular, we investigate dissimilarity measures for shapes encoded by the signed distance function.
ChemInform Abstract: Beyond Petrochemicals: The Renewable Chemicals Industry (2012)

Abstract Review: 41 refs.
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D (1998)

DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-strand break repair and V(D)J recombination, is comprised of a DNA-targeting component termed Ku and an approximately 465-kD catalytic subunit, DNA-PKcs. Although DNA-PK phosphorylates proteins in the presence of DSBs or other discontinuities in the DNA double helix in vitro, the possibility exists that it is also activated in other circumstances via its association with additional proteins. Here, through use of the yeast two-hybrid screen, we discover that the recently identified high affinity DNA binding protein C1D interacts with the putative leucine zipper region of DNA-PKcs. Furthermore, we show that C1D can interact with DNA-PK in mammalian cells and that C1D is a very effective DNA-PK substrate in vitro. Finally, we establish that C1D directs the activation of DNA-PK in a manner that does not require DNA termini. Therefore, these studies provide a function for C1D and suggest novel mechanisms for DNA-PK activation in vivo.
Comparative Analysis Between Various High Specific Power Permanent Magnet Motor Topologies for Aerospace Applications (2022)

Electrification of the aerospace application is crucial to mitigate carbon dioxide emissions. On the other hand, electrical machines are not yet competitive to turbo jet engines in terms power-to-weight ratio, referred to as Specific Power (SP). Thus, non-traditional design techniques should be employed to magnify aerospace motors SP. In this paper, three different machine topologies enabled by Aluminum additively-manufactured coils with integrated heat pipes will be discussed and compared for direct-drive as well as geared solutions. The additively-manufactured designs feature low weight coils, and tight integration to the drive and thermal management system. The three topologies are (i) Inner rotor surface PM (SPM), (ii) Outer rotor SPM, and (iii) Axial flux dual-rotor SPM. The analysis and optimization results will show significantly improved SP compared to the state-of-art electric motors. Additionally, the pros and cons of the various designs will be highlighted.
Individualized Fluid Management Using the Pleth Variability Index (2020)

Among intermediate-risk patients having orthopedic surgery with general anesthesia, fluid administration guided by the plethysmographic variability index did not shorten the duration of hospitalization or reduce complications.
Artificial Intelligence for Healthcare (2020)

We discuss the current and future impact of artificial intelligence (AI) technologies on healthcare. We consider four hierarchical levels of healthcare data generation and processing of increasing complexity and wider implications. At the imaging scanner and instrument level, AI aims at improving, simplifying, and standardizing data acquisition and preparation. We present examples of systems for AI-driven automatic patient iso-centering before a computed tomography scan, deep learning-based image reconstruction, and creation of optimized and standardized visualizations, for example, automatic rib-unfolding. At the reading and reporting levels, AI focuses on the detection and characterization of abnormalities and on automatic measurements in images. We introduce multiple AI systems for the brain, heart, lung, prostate, and musculoskeletal disease. The third level is exemplified by the integrated nature of the clinical data in a patient-specific manner. The AI algorithms at this level focus on risk prediction and stratification, as opposed to merely detecting, measuring, and quantifying images. An AI-based approach for individualizing radiation dose in lung stereotactic body radiotherapy is discussed. The digital twin is presented as a concept of individualized computational modeling of human physiology. Finally, at the cohort and population analysis levels, the focus of AI shifts from clinical decision-making to operational decisions and process optimization.
Metal-Enhanced Fluorescence from Silver Nanowires with High Aspect Ratio on Glass Slides for Biosensing Applications (2014)

High enhancement of fluorescence emission, improved fluorophore photostability, and significant reduction of fluorescence lifetimes have been obtained from high aspect ratio (>100) silver (Ag) nanowires. These quantities are found to depend on the surface loading of Ag nanowires on glass slides, where the enhancement of fluorescence emission increases with the density of nanowires. The surface loading dependence was attributed to the creation of intense electric fields around the network of Ag nanowires and to the coupling of fluorophore excited states that takes place efficiently at a distance of 10 nm from the surface of nanowires, which was confirmed by theoretical calculations. The enhancement of fluorescence emission of fluorescein isothiocyanate (FITC) was assessed by fluorescence spectroscopy and fluorescence-lifetime imaging microscopy (FLIM) to demonstrate the potential of high aspect ratio Ag nanowires. Fluorescence enhancement factors exceeding 14 were observed on Ag nanowires with high loading by FLIM. The photostability of FITC was the highest on nanowires with medium loading under continuous laser excitation for 10 min because of the significant reduction in the fluorescence lifetime of FITC on these surfaces. These results clearly demonstrate the potential of Ag nanowires in metal-enhanced fluorescence-based applications of biosensing on planar surfaces and cellular imaging.
Amelioration of diabetes‐induced cavernosal fibrosis by antioxidant and anti‐transforming growth factor‐β1 therapies in inducible nitric oxide synthase‐deficient mice (2011)

• Both allopurinol and decorin appear as promising approaches either as a single or a combined pharmacological modality for protecting the diabetic corpora from undergoing apoptosis and fibrosis although their functional effects still need to be defined.
Combustion Variability Model for Control of Injection Timing for Diesel Exhaust Heating (2018)

Diesel engine emission cycle data shows that major portions of cycle emissions are produced at the beginning of the test, when the aftertreatment is not at operational temperature (prior to “light-off”) [1]. To reduce diesel emissions, aggressive combustion phasing retard via injection timing can be used to achieve faster aftertreatment light-off, but this method is limited because of vibration and harshness concerns associated with the combustion variability induced by the late combustion phasing. In order to achieve aggressive exhaust heating while mitigating combustion variability concerns, the premise of controlling combustion variability is explored. In particular, a controller will use real-time measurements of combustion features and control injection timing to maintain an acceptable level of combustion variability. The closed loop controller tuning requires an understanding of combustion variability behavior as a function of combustion phasing retard. The characterization of combustion variability using engine experiments is presented, and the findings are used to develop a control-oriented combustion variability model consisting of regressions of the statistics of IMEP as a function of fuel and timing offsets.
Hydrogen Incorporation Modulates Subgap Density of States in Amorphous InGaZnO Thin-Film Transistors (2021)

Incorporation of hydrogen into the channel layer of an amorphous indium gallium zinc oxide (a-IGZO) thin-film transistor leads to a negative shift in the transfer curve threshold voltage; the magnitude of the threshold voltage shift increases with increasing hydrogen content. Although several atomic models for hydrogen incorporation into a-IGZO have been proposed, hydrogen-induced changes in the sub-gap density of states have never before been directly measured. By employing ultrabroadband photoconduction (UBPC), 1,2 we directly observe a large increase in the near-valence band UBPC response in hydrogen-enriched devices; the increase in UBPC response scales with hydrogen concentration. 3 This UBPC trend is consistent with the formation of OH states resulting from the interaction of incorporated hydrogen with oxygen already present in the a-IGZO channel layer and explains the observed negative threshold voltage shift in the device transfer curve. K. T. Vogt, C. Malmberg, J. Buchanan, G. Mattson, M. Brandt, D. Fast, P. H.-Y. Cheong, J. F. Wager, M. W. Graham, (2020) Ultrabroadband Density of States of Amorphous In-Ga-Zn-O , Phys Rev Res, 2, 033358 K. T. Vogt, G. W. Mattson, J. F. Wager, M. W. Graham (2020) Ultrabroadband Photoconduction Response of Sub-gap Defects in Amorphous In-Ga-Zn-O Thin Film Transistors , ECS Transactions, 97 (7), 339-357 G. W. Mattson, K.T. Vogt, C. Malmberg, P. H.-Y. Cheong, J. F. Wager, M. W. Graham, (2020) Effect of hydrogen incorporation on sub-gap density of states in amorphous InGaZnO thin-film transistors , Proc. SPIE, Oxide-based Materials and Devices XI, 112811G, doi.org/10.1117/12.2545439 Figure 1
Multiple Actions of Neurturin Correlate with Spatiotemporal Patterns of Ret Expression in Developing Chick Cranial Ganglion Neurons (1999)

The neurotrophic effects of neurturin (NRTN) on chick cranial ganglia were evaluated at various embryonic stages in vitro and related to its receptor expression. NRTN promoted the outgrowth and survival of ciliary ganglion neurons at early embryonic (E) stages (E6-E12), trigeminal ganglion neurons at midstages (E9-E16), and vestibular ganglion neurons at late stages (E12-E16). NRTN had no positive effects on cochlear ganglion neurons throughout development. In accordance with the time and order of onset in NRTN responsiveness, Ret protein was first detected in ciliary ganglia at E6, subsequently in trigeminal ganglia at E9, and in vestibular ganglia at E12. Ret was absent in E16 ciliary ganglia as well as in cochlear ganglia at all developmental stages that were tested. Exogenous application of retinoic acid induced NRTN responsiveness and Ret protein expression from E9 vestibular ganglion neurons, suggesting that retinoic acid can regulate Ret protein expression in peripheral sensory neurons in vitro. Ret was confined to the neuron cell body, whereas GFRalpha was localized predominantly in peripheral and central neurite processes. No noticeable change in GFRalpha expression was seen in any cranial ganglia throughout the developmental stages that were tested (E6-E16). These results demonstrate that NRTN exerts neurotrophic effects on different cranial ganglia at different developmental stages and that the onset and offset of NRTN responsiveness are regulated mainly by the spatiotemporal patterns of Ret, but not of GFRalpha receptors. The results also substantiate the recently emerging view that NRTN may be an essential target-derived neurotrophic factor for parasympathetic neurons during development.
A Sustainable Autonomic Architecture for Organically Reconfigurable Computing Systems (2011)

A Sustainable Autonomic Architecture for Organically Reconfigurable Computing System based on SRAM Field Programmable Gate Arrays (FPGAs) is proposed, modeled analytically, simulated, prototyped, and measured. Low-level organic elements are analyzed and designed to achieve novel self-monitoring, self-diagnosis, and self-repair organic properties. The prototype of a 2-D spatial gradient Sobel video edge-detection organic system use-case developed on a XC4VSX35 Xilinx Virtex-4 Video Starter Kit is presented. Experimental results demonstrate the applicability of the proposed architecture and provide the infrastructure to quantify the performance and overcome fault-handling limitations. Dynamic online autonomous functionality restoration after a malfunction or functionality shift due to changing requirements is achieved at a fine granularity by exploiting dynamic Partial Reconfiguration (PR) techniques. A Genetic Algorithm (GA)-based hardware/software platform for intrinsic evolvable hardware is designed and evaluated for digital circuit repair using a variety of well-accepted benchmarks. Dynamic bitstream compilation for enhanced mutation and crossover operators is achieved by directly manipulating the bitstream using a layered toolset. Experimental results on the edge-detector organic system prototype have shown complete organic online refurbishment after a hard fault. In contrast to previous toolsets requiring many milliseconds or seconds, an average of 0.47 microseconds is required to perform the genetic mutation, 4.2 microseconds to perform the single point conventional crossover, 3.1 microseconds to perform Partial Match Crossover (PMX) as well as Order Crossover (OX), 2.8 microseconds to perform Cycle Crossover (CX), and 1.1 milliseconds for one input pattern intrinsic evaluation. These represent a performance advantage of three orders of magnitude over the JBITS software framework and more than seven orders of magnitude over the Xilinx design flow. Combinatorial Group Testing (CGT) technique was combined with the conventional GA in what is called CGT-pruned GA to reduce repair time and increase system availability. Results have shown up to 37.6% convergence advantage using the pruned technique. Lastly, a quantitative stochastic sustainability model for reparable systems is formulated to evaluate the Sustainability of FPGA-based reparable systems. This model computes at design-time the resources required for refurbishment to meet mission availability and lifetime requirements in a given fault-susceptible missions. By applying this model to MCNC benchmark circuits and the Sobel Edge-Detector in a realistic space mission use-case on Xilinx Virtex-4 FPGA, we demonstrate a comprehensive model encompassing the inter-relationships between system sustainability and fault rates, utilized, and redundant hardware resources, repair policy parameters and decaying reparability.
Effect of Varying Polyethylene Glycol Chain Length on Enzyme Activity (2014)

It is well-established in research literature that ceria nanoparticles (CNPs) are able to undergo redox reaction with several oxygen-containing species in single or double electron transfers. The oxidase-mimetic ability of these particles, specifically, has found use in several biosensor devices. In this study we sought to characterize and optimize the use of ceria nanoparticles coated in polyethylene glycol (PEG) for use in biosensors. Specifically, molecular weight of adsorbed polymer was varied, particles were allowed to age in solution, and each solution was assayed for catalase activity. Interestingly, this study revealed that different polymer chain lengths of PEG influence self-assembly of particles in solution, thus varying oxidase activity.