gebhart/patrepeval huggingface dataset:
Increased Serpin A5 levels in the cervicovaginal fluid of HIV-1 exposed seronegatives suggest that a subtle balance between serine proteases and their inhibitors may determine susceptibility to HIV-1 infection (2014)

HIV-exposed seronegative individuals (HESNs) are persons who remain seronegative despite repeated exposure to HIV, suggesting an in vivo resistance mechanism to HIV. Elucidation of endogenous factors responsible for this phenomenon may aid in the development of new classes of microbicides and therapeutics. We compared cervicovaginal protein abundance profiles between high-risk HESN and two control groups: low-risk HESN and HIV-positives. Four iTRAQ-based quantitative experiments were performed using samples classified based on presence/absence of particular gynaecological conditions. After statistical analysis, two proteins were shown to be differentially abundant between high-risk HESNs and control groups. Serpin A5, a serine proteinase inhibitor and Myeloblastin, a serine protease, were up- and downregulated, respectively. Commercially available ELISA assays were used to confirm differential Serpin A5 levels. These results suggest that HIV resistance in CVF of HESNs is the result of a delicate balance between two complementary mechanisms: downregulation of serine proteinases and upregulation of their inhibitors.
Koios: A Deep Learning Benchmark Suite for FPGA Architecture and CAD Research (2021)

With the prevalence of deep learning (DL) in many applications, researchers are investigating different ways of optimizing FPGA architecture and CAD to achieve better quality-of-results (QoR) on DL-based workloads. In this optimization process, benchmark circuits are an essential component; the QoR achieved on a set of benchmarks is the main driver for architecture and CAD design choices. However, current academic benchmark suites are inadequate, as they do not capture any designs from the DL domain. This work presents a new suite of DL acceleration benchmark circuits for FPGA architecture and CAD research, called Koios. This suite of 19 circuits covers a wide variety of accelerated neural networks, design sizes, implementation styles, abstraction levels, and numerical precisions. These designs are larger, more data parallel, more heterogeneous, more deeply pipelined, and utilize more FPGA architectural features compared to existing open-source benchmarks. This enables researchers to pin-point architectural inefficiencies for this class of workloads and optimize CAD tools on more realistic benchmarks that stress the CAD algorithms in different ways. In this paper, we describe the designs in our benchmark suite, present results of running them through the Verilog-to-Routing (VTR) flow using a recent FPGA architecture model, and identify key insights from the resulting metrics. On average, our benchmarks have 3.7× more netlist primitives, 1.8× and 4.7× higher DSP and BRAM densities, and 1.7× higher frequency with 1.9× more near-critical paths compared to the widely-used VTR suite. Finally, we present two example case studies showing how architectural exploration for DL-optimized FPGAs can be performed using our new benchmark suite.
Efficient Photocatalytic Oxygenation of Aromatic Alkene to 1,2-Dioxetane with Oxygen via Electron Transfer (2005)

[reaction: see text] Photocatalytic oxygenation of tetraphenylethylene (TPE) with oxygen occurs efficiently via electron-transfer reactions of TPE and oxygen with a photogenerated electron transfer state of 9-mesityl-10-methylacridniium ion, followed by the radical-coupling reaction between TPE radical cation and O2*- to produce 1,2-dioxetane selectively. The further photocatalytic cleavage of the O-O bond of dioxetane affords benzophenone as the final oxygenated product.
Efficiency Enhancement of GaN/InGaN Vertical-Injection Light Emitting Diodes Using Distinctive Indium-Tin-Oxide Nanorods (2009)

Distinctive indium-tin-oxide nanorods are demonstrated using glancing-angle deposition. The nanostructured material exhibit enhanced transmission and is employed to enhance the light-output-power of GaN/InGaN vertical-injection light emitting diodes by 20% at an injection current of 350mA.
On-Road Emissions in Asia Measured by Remote Sensing (2005)

On-road emissions are precisely the emissions which are impacting the air quality and which need to be controlled if air quality improvements are desired. Remote sensing measures mass emissions of CO, HC, NO and smoke per kg (or per L) of fuel burned. On-road emissions are not certification emissions for new vehicles, although new vehicles measured on-road most often provide remote sensing readings well within their certification values. On-road emissions are not the same as readings from scheduled emission tests, although on average the two correlate very well. The major difference between scheduled emission tests and on-road emissions readings is how emissions variability is treated. All emissions tests show low variability when testing new, well controlled vehicles and show very high variability when testing older, and especially older broken, vehicles. Because on-road remote sensing readings can be obtained with a throughput of 10,000 vehicles per day, the variability of readings taken day after day on the same vehicle is readily apparent. By contrast, scheduled emission tests tend to be performed only once for vehicles which pass the first time (most vehicles) and are only repeated for vehicles which fail the first time. It has been shown from analysis of US data that many of the vehicles which subsequently receive passing readings do so because their emissions naturally vary and happen on the first test to be high and the second test low. Roadside tests in California carried out by their Bureau of Automotive Repair show that vehicles identified as on-road gross emitters by means of remote sensing and pulled over immediately by a policeman have an 83-88 % (depending on the pollutant) chance of failing a California emissions test performed on the spot. On road emissions measured in Asia show large geographic variability and everywhere that a few vehicles are responsible for most of the on-road emissions.
Demand estimation in dense and efficient small cell architectures (2015)

We consider a heterogeneous network scenario where macro cells provide continuous coverage and many small cells with short transmission ranges within the coverage area of each macro cell provide high capacity access. We focus on scenarios where most small cells can be put on the sleep mode and macro cell capacity is sufficient for serving a large fraction of user population. Few users generate high demand and thus a small fraction of small cell base stations (SC-BS) that can serve these users should be ideally powered on to offload the macro cell base station (MC-BS). As different sets of users create demand surge over time, a network controller should keep track of peak demand locations and power on a minimal number of SC-BSs. We propose a new solution to this end. Our solution iteratively determines which SC-BSs should be turned on and performs power control to dictate the coverage area of each SC-BS. We use the flow byte counters on the MC-BS and active SC-BSs to form a system of linear equations and use linear optimization using L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> norm of the demand vector as the objective function to localize the demand. Our evaluations indicate that the solution is quite effective in tracking the peak demand locations. For instance in one particularly challenging scenario with heavy-tailed i.i.d. spatial distribution for peak demand, 80% of the peak demand locations were identified correctly more than 90% of the time using less than 7% of the SC-BSs.
Influence of Adsorption and Catalytic Reaction on Sensing Properties of a Potentiometric La[sub 2]CuO[sub 4]∕YSZ∕Pt Sensor (2007)

This study describes the gas-sensing properties of a potentiometric sensor and discusses its sensing mechanism in terms of the adsorptive and catalytic behavior of the electrode materials. The sensor is highly sensitive to , , and , but virtually no response is observed for and detection. Optimal sensing is obtained at . Above , there is an abrupt decrease in sensitivity. Below , there is a saturation of the response. The sensor is selective against , but its sensitivity is affected significantly by and . This selectivity behavior is in good agreement with temperature-programmed desorption results, indicating that the response is very likely adsorption-related. For example, the chemisorption peak disappears in the presence of , which agrees with the sensor results showing a significant decrease in the sensitivity by addition even though itself shows no sensor response.
Identification of a methyltransferase catalyzing the final step of methyl anthranilate synthesis in cultivated strawberry (2017)

These analyses indicate that the methyltransferase, now noted ANTHRANILIC ACID METHYL TRANSFERASE (FanAAMT), mediates the ultimate step of MA production in cultivated strawberry. Identification of this gene and its associated molecular marker may hasten breeding efforts to introduce this important volatile into modern cultivars.
Synthetic Talc and Talc‐Like Structures: Preparation, Features and Applications (2017)

This contribution gives a comprehensive review about the progress in preparation methods, properties and applications of the different synthetic talc types: i) crystalline nanotalc synthesized by hydrothermal treatment; ii) amorphous and/or short-range order nanotalc obtained by precipitation, and iii) organic-inorganic hybrid talc-like structures obtained through a sol-gel process or a chemical grafting. Several advantages of nanotalc such as high chemical purity, high surface area, tunable submicronic size, high thermal stability, and hydrophilic character (leading to be the first fluid mineral) are emphasized. Synthetic nanotalc applications are also considered including its use as nanofiller in composite materials, as absorbers of organic compounds, as anticorrosion coatings and as agents for cosmetic applications. Regarding their high industrial application potential, intensive research has been carried out to better understand their behavior and develop processes to produce them. To facilitate further research and development, scientific and technical challenges are discussed in this Review article.
ChemInform Abstract: Novel Esters and Amides of Nonsteroidal Antiinflammatory Carboxylic Acids as Antioxidants and Antiproliferative Agents. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Learning Continuous Treatment Policy and Bipartite Embeddings for Matching with Heterogeneous Causal Effects (2020)

Causal inference methods are widely applied in the fields of medicine, policy, and economics. Central to these applications is the estimation of treatment effects to make decisions. Current methods make binary yes-or-no decisions based on the treatment effect of a single outcome dimension. These methods are unable to capture continuous space treatment policies with a measure of intensity. They also lack the capacity to consider the complexity of treatment such as matching candidate treatments with the subject. We propose to formulate the effectiveness of treatment as a parametrizable model, expanding to a multitude of treatment intensities and complexities through the continuous policy treatment function, and the likelihood of matching. Our proposal to decompose treatment effect functions into effectiveness factors presents a framework to model a rich space of actions using causal inference. We utilize deep learning to optimize the desired holistic metric space instead of predicting single-dimensional treatment counterfactual. This approach employs a population-wide effectiveness measure and significantly improves the overall effectiveness of the model. The performance of our algorithms is. demonstrated with experiments. When using generic continuous space treatments and matching architecture, we observe a 41% improvement upon prior art with cost-effectiveness and 68% improvement upon a similar method in the average treatment effect. The algorithms capture subtle variations in treatment space, structures the efficient optimizations techniques, and opens up the arena for many applications.
Cationic electron‐beam curing of a high‐functionality epoxy: effect of post‐curing on glass transition and conversion (2004)

Abstract This paper reports on the cationic electron‐beam curing of a high‐functionality SU8 epoxy resin, which is extensively used as a UV‐curing negative photoresist for micro‐electronics machine systems (MEMS) applications. Results show that elevated post‐curing treatment significantly increased both the conversion and the glass transition. The degree of conversion and the glass transition temperature were measured by using Fourier‐transform infrared (FTIR) spectroscopy and modulated differential scanning calorimetry (MDSC ® ), respectively. The glass transition temperature ( T g ), which has been observed to be dependent on the degree of conversion, reaches a maximum of 162 °C at 50 Mrad and post‐curing at 90 °C. The degradation pattern of the cured resin does not show much variation for exposure at 5 Mrad, but does show significant variation for 50 Mrad exposure at various post‐curing temperatures. A degree of conversion of more than 0.8 was achieved at a dosage of 30 Mrad with post curing at 80 °C, for the epoxy resin with an average functionality of 8 a feature simply not achievable when using UV‐curing. Copyright © 2004 Society of Chemical Industry
Supplementary Figure 3 from Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity (2023)

&lt;p&gt;PDF file, 86K, In-vitro activity of MBV on DC.&lt;/p&gt;
Interface pressure and shear stress changes with amputee weight loss (2002)

Interface pressures and shear stresses were measured at monthly intervals on two trans-tibial amputee subjects who lost more than 12% of their body weight over the course of the study. For one subject interface pressures and shear stresses during the weight-acceptance phase of gait decreased over the study interval at all 13 sites monitored, while the other subject experienced increased pressures distally but decreased pressures proximally. Subjects' stumps appeared to atrophy over the study interval, increasing distal end and patellar tendon loading, but not increasing interface shear stresses at other locations. Adding socks at the end of the study did not return interface pressures to first session values at all sites. It is expected that local stump shape changes occurred, causing a non-uniform change in interface stress patterns.
Serology Enhances Molecular Diagnosis of Respiratory Virus Infections Other than Influenza in Children and Adults Hospitalized with Community-Acquired Pneumonia (2016)

Both molecular and serological assays have been used previously to determine the etiology of community-acquired pneumonia (CAP). However, the extent to which these methods are correlated and the added diagnostic value of serology for respiratory viruses other than influenza virus have not been fully evaluated. Using data from patients enrolled in the Centers for Disease Control and Prevention (CDC) Etiology of Pneumonia in the Community (EPIC) study, we compared real-time reverse transcription-PCR (RT-PCR) and serology for the diagnosis of respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza virus 1 to 3 (PIV1, PIV2, and PIV3), and adenovirus (AdV) infections. Of 5,126 patients enrolled, RT-PCR and serology test results were available for 2,023, including 1,087 children below the age of 18 years and 936 adults. For RSV, 287 (14.2%) patients were positive by RT-PCR and 234 (11.6%) were positive by serology; for HMPV, 172 (8.5%) tested positive by RT-PCR and 147 (7.3%) by serology; for the PIVs, 94 (4.6%) tested positive by RT-PCR and 92 (4.6%) by serology; and for AdV, 111 (5.5%) tested positive by RT-PCR and 62 (3.1%) by serology. RT-PCR provided the highest number of positive detections overall, but serology increased diagnostic yield for RSV (by 11.8%), HMPV (by 25.0%), AdV (by 32.4%), and PIV (by 48.9%). The method concordance estimated by Cohen's kappa coefficient (κ) ranged from good (for RSV; κ = 0.73) to fair (for AdV; κ = 0.27). Heterotypic seroresponses observed between PIVs and persistent low-level AdV shedding may account for the higher method discordance observed with each of these viruses. Serology can be a helpful adjunct to RT-PCR for research-based assessment of the etiologic contribution of respiratory viruses other than influenza virus to CAP.
Novel mRNA Targets for Tristetraprolin (TTP) Identified by Global Analysis of Stabilized Transcripts in TTP-Deficient Fibroblasts (2006)

Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice and cells derived from them showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRNA deadenylation and destruction. Known physiological target mRNAs for TTP include tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and interleukin-2beta. Here we used microarray analysis of RNA from wild-type and TTP-deficient fibroblast cell lines to identify transcripts with different decay rates, after serum stimulation and actinomycin D treatment. Of 250 mRNAs apparently stabilized in the absence of TTP, 23 contained two or more conserved TTP binding sites; nine of these appeared to be stabilized on Northern blots. The most dramatically affected transcript encoded the protein Ier3, recently implicated in the physiological control of blood pressure. The Ier3 transcript contained several conserved TTP binding sites that could bind TTP directly and conferred TTP sensitivity to the mRNA in cell transfection studies. These studies have identified several new, physiologically relevant TTP target transcripts in fibroblasts; these target mRNAs encode proteins from a variety of functional classes.
ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration (2019)

Tremendous amount of whole-genome sequencing data have been provided by large consortium projects such as TCGA (The Cancer Genome Atlas), COSMIC and so on, which creates incredible opportunities for functional gene research and cancer associated mechanism uncovering. While the existing web servers are valuable and widely used, many whole genome analysis functions urgently needed by experimental biologists are still not adequately addressed. A cloud-based platform, named CG (ClickGene), therefore, was developed for DIY analyzing of user's private in-house data or public genome data without any requirement of software installation or system configuration. CG platform provides key interactive and customized functions including Bee-swarm plot, linear regression analyses, Mountain plot, Directional Manhattan plot, Deflection plot and Volcano plot. Using these tools, global profiling or individual gene distributions for expression and copy number variation (CNV) analyses can be generated by only mouse button clicking. The easy accessibility of such comprehensive pan-cancer genome analysis greatly facilitates data mining in wide research areas, such as therapeutic discovery process. Therefore, it fills in the gaps between big cancer genomics data and the delivery of integrated knowledge to end-users, thus helping unleash the value of the current data resources. More importantly, unlike other R-based web platforms, Dubbo, a cloud distributed service governance framework for 'big data' stream global transferring, was used to develop CG platform. After being developed, CG is run on an independent cloud-server, which ensures its steady global accessibility. More than 2 years running history of CG proved that advanced plots for hundreds of whole-genome data can be created through it within seconds by end-users anytime and anywhere. CG is available at http://www.clickgenome.org/.
1α-Hydroxyarteether, a New Microbial Transformation Product (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1α-Hydroxyarteether, a New Microbial Transformation ProductCharles D. Hufford, Sherief I. Khalifa, Khaled Y. Orabi, Frank T. Wiggers, Ramu Kumar, Robin D. Rogers, and Charles F. CampanaCite this: J. Nat. Prod. 1995, 58, 5, 751–755Publication Date (Print):May 1, 1995Publication History Published online1 July 2004Published inissue 1 May 1995https://doi.org/10.1021/np50119a016RIGHTS & PERMISSIONSArticle Views98Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (326 KB) Get e-Alertsclose Get e-Alerts
[Radiotherapy in advanced osseous destruction in chronic myeloid leukemia. A case report]. (1996)

This case report confirms the high effectiveness of palliative radiotherapy even in advanced cases of myelosarcomas which has been described in literature.
Readability assessment of patient educational materials for shoulder arthroplasty from top academic orthopedic institutions (2021)

Shoulder arthroplasty online patient educational material at top-ranked orthopedic institutions have poor readability and are likely not suitable for the majority of patients in the United States.
Effects of estrogen on vaginal innervation (2012)

Menopause: June 2012 - Volume 19 - Issue 6 - p 604-605 doi: 10.1097/gme.0b013e31824f5cbb
Toward the potential of electrowetting microprisms: High performance liquids, low voltage dielectrics, and 3D lithography (2008)

Electrowetting microprisms are projected to provide high performance for beam steering. To achieve this goal, high performance liquids, low voltage dielectrics, and 3D lithography are now in development. In this paper, we will review the operational basics of electrowetting microprisms, and the above-mentioned three key factors.