gebhart/patrepeval huggingface dataset:
Clinical Cytometry in Europe, 2010 (2010)

This year, the European Society for Clinical Cell Analysis (ESCCA) and the Iberian Society for Cytometry (SIC) jointly organized in Valencia (Spain) the 10th Euroconference on Clinical Cell Analysis in conjunction with the 6th European Clinical Cytometry Course. As of September 1, 385 paying participants from 45 countries had signed up for the 3-day conference and 220 for one of six 2-day courses, respectively. The 6th European Course offered lectures, debates, practical exercises, and data analysis sessions on the six themes that were decided this year: immunophenotyping of leukemias and lymphomas, immunodeficiency, integrated cytomics, cellular biomarkers of cancer, functional cytometry, and paroxysmal nocturnal hemoglobinuria. The scientific programme of the 10th Euroconference included interdisciplinary topics favored to confront and exchange common and specific approaches. Besides the keynote lecture and the presentation of the 2009–2010 best paper in Clinical Cytometry, an extensive program with plenary and parallel lectures was provided. Six proferred abstracts were selected for oral presentation. Morethan 100 posters were on display, whereas a further 10 were highlighted during two “poster walks.” All invited presentations, selected proferred abstracts, and abstracts that were shown as posters are shown, in abstract form, in this issue of Clinical Cytometry (see Table 1). From 2005 onward, the Euroconferences make use of a so-called interactive voting system (IVS) that enable the participants to cast their votes on statements and questions prepared by the moderators of specific sessions. This year, the IVS served to structure debates on the detection of circulating tumor cells (cell-based vs. molecular-based), and on the limits of flow cytometry in rare event detection, focused on leukemia/lymphoma immunophenotyping, and circulating endothelial cells. The 7th European Clinical Cytometry Course, the 11th Euroconference on Clinical Cell Analysis and the Joint Meeting of ISAC (International Society for Advancement of Cytometry), International Clinical Cytometry Society (iCCS), Irish Society for Cytometry (ICyS), and ESCCA will be held in Dublin, Ireland, from September 13–14, 2011 (Joint Meeting and European Course) and from September 14–17, 2011 (Euroconference), under the co-chairmanship of Alfonso Blanco and Jan Gratama. For details, see www.cytometry2011.eu. As scientific organizing committee, we are very pleased for the financial support of our 23 industrial partners, and for the financial and logistical support provided by the Generalitat Valenciana, the University of Valencia, the Centro de Investigación Principe Felipe, the Valencian Council of Culture, and the International Federation of Clinical Chemistry and Laboratory Medicine. In particular, we are very grateful to the International Clinical Cytometry Society (iCCS) and the Clinical Cytometry journal to publish the abstracts of the Conference.
Heterogeneous Strain Distribution and Saturation of Geometrically Necessary Dislocations in a Ferritic–Pearlitic Steel during Lubricated Sliding (2018)

The microstructural evolution of ferritic–pearlitic steel is studied during unidirectional sliding under boundary lubrication using a ball‐on‐flat configuration. Dislocation activity as a function of distance to surface is determined using orientation gradients by electron backscatter diffraction in logarithmic intervals up to one million of sliding cycles. The orientation gradient results show the formation of geometrically necessary dislocations and low‐angle grain boundaries, followed by a consolidation of those grain boundaries as nanocrystalline grains. The density of geometrically necessary dislocations and low‐angle grain boundaries is observed to reach a steady state after around 100 000 cycles. Plastic strain is not homogeneously distributed within both material phases, that is, ferrite and pearlite. Most of the plastic deformation is carried by the ferritic phase. The heterogeneous strain distribution between the ferritic and the pearlitic phase observed in the electron backscatter diffraction measurements is attributed to stress incompatibilities at the grain boundaries. Dislocation pile‐up at the ferritic–pearlitic interface is observed at high resolution using transmission electron microscopy and transmission Kikuchi diffraction.
Parasites ofHeliothisspp. (Lepidoptera: Noctuidae): Parasitism and Seasonal Occurrence for Host Crops in the Texas Rolling Plains (1985)

Journal Article Parasites of Heliothis spp. (Lepidoptera: Noctuidae): Parasitism and Seasonal Occurrence for Host Crops in the Texas Rolling Plains Get access G. J. Puterka, G. J. Puterka Texas A&M University Agricultural Research and Extension Center at Chillicothe-Vernon, Vernon, Texas 76384 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. E. Slosser, J. E. Slosser Texas A&M University Agricultural Research and Extension Center at Chillicothe-Vernon, Vernon, Texas 76384 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Price J. R. Price 1 Texas A&M University Agricultural Research and Extension Center at Chillicothe-Vernon, Vernon, Texas 76384 1 Texas Agricultural Experiment Station, P.O. Box 1658, Vernon, TX 76384. Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 14, Issue 4, 1 August 1985, Pages 441–446, https://doi.org/10.1093/ee/14.4.441 Published: 01 August 1985 Article history Received: 16 August 1984 Accepted: 08 April 1985 Published: 01 August 1985
DISPOSABLE EYELID SPECULUM DESIGNED FOR INTRAVITREAL INJECTION (2011)

Gomi, Fumi MD*; Matsuda, Yuji PhD†; Futamura, Hideyuki†; Nishida, Kohji MD* Author Information
4‐ketoproline: An electrophilic proline analog for bioconjugation (2015)

Installing an electrophilic amino-acid residue can engender a peptide or protein with chemoselective reactivity. Such a modification to collagen, which is the most abundant protein in animals, could facilitate the development of new biomaterials. Collagen has an abundance of proline-like residues. Here, we report on the incorporation of an electrophilic proline congener, (2S)-4-ketoproline (Kep), into a collagen-mimetic peptide (CMP). An ab initio conformational analysis of Kep revealed its potential to be accommodated within a collagen triple helix. A synthetic CMP containing a Kep residue was indeed able to form a stable triple helix. Moreover, the condensation of its carbonyl group with aminooxy-biotin did not compromise the conformational stability of the triple helix. These data encourage the use of 4-ketoproline as an electrophilic congener of proline.
Reply to “Comments on `Quantization Noise as Superposition of Frequency Modulated Sinusoids' ” (2010)

The author acknowledges that the possibility of regarding the quantization noise as superposition of phase-modulated sinusoids has been described previously in the work of Claasen and Jongepier. However, to the defense of the author and the anonymous reviewers, that work has been cited only 13 times since its publication and the date of the submission of the paper of Zierhofer, and the citations do not hint at the relationship between frequency or phase modulation and quantization noise.
Tunable elastic dielectric metasurface lenses (2023)

Metasurfaces comprise an array of meta-atoms in a stretchable polymer. The dimensions and shapes of the meta-atoms and the spacing are varied to obtain desired optical properties. Any optical wavefront, for different wavelengths, illumination angles, and polarization states can be designed with proper design of the meta-atoms. As the metasurface is stretched, the distance between the meta-atoms changes, modifying the optical response, while the dimensions of the meta-atoms remains constant.
Effect of flunixin meglumine on Escherichia coli heat-stable enterotoxin-induced diarrhea in calves (1988)

In a study to evaluate the effect of flunixin meglumine on secretory diarrhea, 11 calves were assigned to 3 groups: group 1 (n = 3) served as controls, group-2 calves (n = 4) were given 2.2 mg of flunixin meglumine/kg, IM at 7 AM and 3 PM, and group-3 calves (n = 4) were given 2.2 mg of flunixin meglumine/kg, IM at 7 AM, 11 AM, and 3 PM. All calves were given approximately 200 micrograms of heat-stable Escherichia coli enterotoxin (STa) orally at 8 AM. Mean cumulative fecal output for groups 1, 2, and 3 was 1,331.0 +/- 317.2 g, 1,544.3 +/- 154.4 g, and 785.5 +/- 276.5 g, respectively. There was a significant (P less than 0.05) reduction in mean fecal output in group-3 calves, compared with that in groups 1 and 2. Calves in group 2 tended to have a delay, but not a reduction, in their fecal output. At 12 hours, hemoconcentration was significantly (P less than 0.05) greater in group-1 calves than in group-2 or group-3 calves.
P-Gate: Pushing the operator service platform towards the network edge (2009)

In order to extend the coverage of network-based services to the home environment and offload core network servers, this paper presents a novel service platform called P-Gate that resides in home gateways such as femtocells or wireless LAN access points. The P-Gate platform allows for scalability through self-organized overlay techniques and supports a full integration with centralized service nodes such as the IP Multimedia Subsystem (IMS) to provide functionality like authorization, accounting and bootstrapping. The overlay system scalability has been shown through large-scale simulations and in a Planet - Lab deployment. Further, we have implemented the P-Gate platform on the basis of wireless LAN access points. It serves as a testbed for IMS evolution concepts towards a next generation service platform based on distributed service nodes.
Linear‐nonlinear dichotomy of the rheological response of particle‐filled polymers (2014)

ABSTRACT Novel nanoparticles, polymer‐particle coupling agents, and functionalized polymers are being developed to enhance the performance of particle‐reinforced polymer systems such as advanced rubber compounds for automobile tires. Understanding the complex rheological behavior of rubber is critical to providing insights into both processability and end‐use properties. One unique aspect of the rheology of filled elastomers is that the incorporation of particles introduces a hysteretic softening (Payne effect) at small dynamic strains. This study demonstrates that this nonlinear viscoelastic behavior needs to be considered when attempting to correlate steady shear response (Mooney viscosity) to oscillatory shear measurements from test equipment such as the Rubber Process Analyzer (RPA). While a wide array of unfilled gum elastomers show good correlation between Mooney viscosity and dynamic torque from the RPA at all of the strain amplitudes used, rubber compounds containing silica and carbon black particles only exhibit good agreement between the two measures of processability when the oscillatory strain amplitude is high enough to sufficiently break up the filler network. Other features of the filler network and its influence on nonlinear rheology are considered in this investigation, including the effects of polymer–filler interactions on filler flocculation and the use of Fourier transform rheometry to illustrate the “linear‐nonlinear dichotomy” of the Payne effect. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40818.
Regional and temporal control of genetic transcription in phage lambda. (1966)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy (2023)

The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food and Drug Administration approval for treatment of estrogen receptor (ER)-positive, human epidermal growth factor receptor (Her)2-negative breast cancer in combination with the ER degrader fulvestrant. However, CDK4/6 inhibitors are not cancer-specific and may affect also other proliferating cells. Given the importance of T cells in antitumor defense, we studied the influence of palbociclib/fulvestrant on human CD3+ T cells and novel emerging T cell-based cancer immunotherapies. Palbociclib considerably inhibited the proliferation of activated T cells by mediating G0/G1 cell cycle arrest. However, after stopping the drug supply this suppression was fully reversible. In light of combination approaches, we further investigated the effect of palbociclib/fulvestrant on T cell-based immunotherapies by using a CD3-PSCA bispecific antibody or universal chimeric antigen receptor (UniCAR) T cells. Thereby, we observed that palbociclib clearly impaired T cell expansion. This effect resulted in a lower total concentration of interferon-γ and tumor necrosis factor, while palbociclib did not inhibit the average cytokine release per cell. In addition, the cytotoxic potential of the redirected T cells was unaffected by palbociclib and fulvestrant. Overall, these novel findings may have implications for the design of treatment modalities combining CDK4/6 inhibition and T cell-based cancer immunotherapeutic strategies.
Quantization errors in the computation of the discrete Hartley transform (1987)

The principal objective of this paper is the study of the arithmetic roundoff error characteristics of several discrete Hartley transform (DHT) algorithms. We first summarize a variety of efficient DHT algorithms including Bracewell's original decimation-in-time radix-2 algorithm. Statistical models for fixed- and floating-point arithmetic roundoff errors are then used as the basis for a theoretical study of roundoff noise characteristics of a number of the DHT algorithms. The results of a detailed experimental study of roundoff noise are compared to the theoretical predictions. In fixed-point implementation of the decimation-in-time and frequency radix-2 algorithms, it is found that the noise-to-signal ratio increases approximately 1.1 bits per stage. For the floating-point implementation, the number of bits of rms noise-to-signal ratio for all the algorithms increase as <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sqrt{\log_{2}N}</tex> , so that doubling the number of points produced a mild increase in the output noise.
Effects of Lithium Bis(oxalate)borate Electrolyte Additive on the Formation of a Solid Electrolyte Interphase on Amorphous Carbon Electrodes by Operando Time-Slicing Neutron Reflectometry (2022)

Comprehensive analyses were performed using neutron reflectivity and hard X-ray photoelectron spectroscopy to understand the structure and composition of the solid electrolyte interphase (SEI) layer during charge-discharge processes and because of the addition of lithium bis(oxalate)borate (LiBOB) to improve the battery performance. The chemical composition of the SEI was assessed using these methods, and the amount of Li<sup>+</sup> intercalated in the anode during the electrochemical reaction was evaluated. The results demonstrated that Li<sub>2</sub>C<sub>2</sub>O<sub>4</sub> was produced initially but later decomposed to Li<sub>2</sub>CO<sub>3</sub> on the first charge cycle. Presumably, the SEI layer formed by the decomposition of LiBOB was a single dense layer and chemically stable during the further charge-discharge processes owing to the difference in the reaction process. Therefore, the reduced Li<sup>+</sup> transfer resistance and charging capacity accounted for the substantial improvement contributed by adding LiBOB. Moreover, the charges used for the intercalation of Li<sup>+</sup> and SEI formation during the two-cycle processes were analyzed. The addition of LiBOB increased the discharge capacity of the anode and provided an additional charge used for SEI formation, presumably for decomposing Li<sub>2</sub>C<sub>2</sub>O<sub>4</sub>, which could reflect the durability of the Li-ion batteries. The electrode, electrolyte, and charge-discharge reactions affect the SEI properties and consequently the electrochemical reactions. Therefore, additional investigations under different charge-discharge conditions would reveal important characteristics such as the charge and discharge efficiency, output performance, and safety.
A sampled-grating model of moire patterns from digital imaging (2018)

Abstract: "Traditional "crossed-grating" moire, as well as newer "sampled-grating" (scanning) moire, have proven to be effective methods of shape measurement. There is speculation that the moire patterns of a sampled grating, which are due to aliasing, can be modeled with crossed gratings. We compare the two and show that while crossed gratings can correctly predict the frequencies of a sampled grating, they cannot correctly predict the amplitudes. We go on to formulate a new model which accounts for multiple stages of sampling and transmission, and show how neglecting multiple stages can lead to mistakes in moire analysis. We demonstrate our model with an experiment using a digital imaging system."
Reactions of Tempo with Alkylsamarium and Other Organometallic Reagents (1996)

Reactions of various alkylmetals with Tempo have been studied. Depending on the metal, the alkyl-Temp adduct was obtained in poor to good yield. Alkylsamarium reagents are useful because they are easily to prepare and highly reactive towards Tempo.
Selective ammonia oxidation on vanadia-titania catalysts (2014)

Trabajo presentado en la 248th American Chemical Society National Meeting &amp; Exposition (Chemistry &amp; Global Stewardship), celebrada en San Francisco del 10 al 14 de agosto de 2014.
Assembly and preliminary testing of the prototype 650 GHz BWO (2008)

Approximately twenty intricate diamond structures have been fabricated, selectively metallized and assembled into prototype 650 GHz backward wave oscillators (BWOs). The chemical vapor deposition (CVD) diamond structure is grown into a silicon mold fabricated using deep reactive ion etching. The lithographic fabrication processes employed produce dozens of devices from each lot. The RF power generated is radiated directly from the BWO for compatibility with a quasi-optical sub-mm system. The interdigital slow wave circuit, the electron gun, the output coupler and the antenna are fabricated as a single piece of diamond to eliminate difficulties with alignment. We will describe the processes of fabrication and assembly, and present available preliminary results of prototype testing.
A simple test for the cleavage activity of customized endonucleases in plants (2016)

A convenient procedure to assay the cleavage activity of customized endonucleases has been established. The system is independent of the endonuclease platform and operates in both di- and monocotyledonous hosts. It not only enables the validation of a TALEN/RGEN's functionality prior to the creation of stable mutants, but also serves as a suitable tool to optimize the design of endonuclease constructs.
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018)

Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly one in nine elderly people in the United States. Population studies have shown that an inheritance of the apolipoprotein E (APOE) variant APOE4 allele increases the risk of developing AD, whereas APOE2 homozygotes are protected from late-onset AD. It was hypothesized that expression of the "protective" APOE2 variant by genetic modification of the central nervous system (CNS) of APOE4 homozygotes could reverse or prevent progressive neurologic damage. To assess the CNS distribution and safety of APOE2 gene therapy for AD in a large-animal model, intraparenchymal, intracisternal, and intraventricular routes of delivery to the CNS of nonhuman primates of AAVrh.10hAPOE2-HA, an AAVrh.10 serotype coding for an HA-tagged human APOE2 cDNA sequence, were evaluated. To evaluate the route of delivery that achieves the widest extent of APOE2 expression in the CNS, the expression of APOE2 in the CNS was evaluated 2 months following vector administration for APOE2 DNA, mRNA, and protein. Finally, using conventional toxicology assays, the safety of the best route of delivery was assessed. The data demonstrated that while all three routes are capable of mediating ApoE2 expression in AD relevant regions, intracisternal delivery of AAVrh.10hAPOE2-HA safely mediated wide distribution of ApoE2 with the least invasive surgical intervention, thus providing the optimal strategy to deliver vector-mediated human APOE2 to the CNS.
extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant population of human lymphoma cells (2006)

4401 Sphingolipids and their metabolites participate in cellular signaling and proliferation, and modify several other cellular functions. Of these, ceramide has ability to coordinate a cell’s response to various forms of stress, including cell cycle arrest, cell senescence and apoptosis. In ceramide metabolism, ceramidases catalyze the breakdown of ceramide to sphingosine and the inhibition of ceramidase activity results in the intracellular accumulation of ceramide leading to apoptosis. Herein, we report that modulation of ceramide metabolism by extended treatment with a ceramidase inhibitor allows cells to acquire resistance to radiation-induced apoptosis in a radiosensitive human T cell lymphoma cell line. H9 cells, a human T cell lymphoma cell line, were cultured in medium with the acid ceramidase inhibitor N-oleoyl-ethanolamine (NOE), starting at a concentration level of 10 μM, with gradual increases to an NOE concentration of 100 μM. The cells were maintained in culture at a final NOE concentration of 100 μM. The period for treatment of NOE in medium was 2 days, every 2 weeks. For these experiments, H9 cells were cultured with NOE for more than 6 months. Both untreated and NOE-treated H9 (NOE-H9) cells were irradiated with doses of 0 to 8 Gy. Lipid analysis in these cells was investigated by mass spectrometry. Intracellular accumulation of ceramide was observed in untreated H9 cells after 48hr culture with 100 μM NOE, and greater than 50% of the cells died by apoptosis. Interestingly, there was no intracellular accumulation of ceramide in NOE-treated H9 cells, even after exposure to 100μM NOE. The viability of NOE-treated H9 cells at 48hr post-irradiation with a dose of 8 Gy was significantly higher than that in untreated H9 cells (74.0 ± 3.9% vs. 42.5 ± 1.1%, p=0.0002). Moreover, the intracellular accumulation of ceramide in NOE-H9 cells at 48hr after irradiation with a dose of 8 Gy was significantly less than that in untreated H9 cells (p=0.003). These results suggest that the absence of intracellular accumulation of ceramide following irradiation, through the modulation of ceramide metabolism using an acid ceramidase inhibitor for extended periods of time in culture, represents one potential mechanism for the development of radioresistance.
Mechanical properties, morphology, and flame retardance of glass fiber-reinforced polyamide-toughened novolac-type phenolic resin (1999)

The mechanical properties (tensile, flexural modulus, and impact strength) and the flame retardance of glass fiber-reinforced novolac-type phenolic resin modified with polyamide (PA-6, PA-66) were investigated. Results show that polyamide improves the mechanical properties of composites, especially for the impact strength up to 1.5-fold which shows a maximum value at 7 wt % of polyamide content. The interface between the matrix and glass fiber is increased due to the hydrogen-bonding function present in the polyamide chain. This modified phenolic composite shows excellent flame retardance, that is, UL-94, V-0, and LOI is higher than 55. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 73: 881–887, 1999