gebhart/patrepeval huggingface dataset:
Data from A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Salt-inducible kinase 2 (SIK2) is a centrosome kinase required for mitotic spindle formation and a potential target for ovarian cancer therapy. Here, we examine the effects of a novel small-molecule SIK2 inhibitor, ARN-3236, on sensitivity to paclitaxel in ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; SIK2 expression was determined in ovarian cancer tissue samples and cell lines. ARN-3236 was tested for its efficiency to inhibit growth and enhance paclitaxel sensitivity in cultures and xenografts of ovarian cancer cell lines. SIK2 siRNA and ARN-3236 were compared for their ability to produce nuclear–centrosome dissociation, inhibit centrosome splitting, block mitotic progression, induce tetraploidy, trigger apoptotic cell death, and reduce AKT/survivin signaling.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; SIK2 is overexpressed in approximately 30% of high-grade serous ovarian cancers. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC&lt;sub&gt;50&lt;/sub&gt; of 0.8 to 2.6 μmol/L, where the IC&lt;sub&gt;50&lt;/sub&gt; of ARN-3236 was inversely correlated with endogenous SIK2 expression (Pearson &lt;i&gt;r&lt;/i&gt; = −0.642, &lt;i&gt;P&lt;/i&gt; = 0.03). ARN-3236 enhanced sensitivity to paclitaxel in 8 of 10 cell lines, as well as in SKOv3ip (&lt;i&gt;P&lt;/i&gt; = 0.028) and OVCAR8 xenografts. In at least three cell lines, a synergistic interaction was observed. ARN-3236 uncoupled the centrosome from the nucleus in interphase, blocked centrosome separation in mitosis, caused prometaphase arrest, and induced apoptotic cell death and tetraploidy. ARN-3236 also inhibited AKT phosphorylation and attenuated survivin expression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; ARN-3236 is the first orally available inhibitor of SIK2 to be evaluated against ovarian cancer in preclinical models and shows promise in inhibiting ovarian cancer growth and enhancing paclitaxel chemosensitivity. &lt;i&gt;Clin Cancer Res; 23(8); 1945–54. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Adding an authorization dimension to strong type checking (1988)

article Free Access Share on Adding an authorization dimension to strong type checking Author: Scott N. Gerard IBM Corporation, Rochester, MN IBM Corporation, Rochester, MNView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 23Issue 6June, 1988 pp 145–151https://doi.org/10.1145/44546.44561Online:01 June 1988Publication History 0citation112DownloadsMetricsTotal Citations0Total Downloads112Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Reduction in circulating monocytes correlates with persistent post-COVID pulmonary fibrosis in multi-omic comparison of long-haul COVID and IPF (2022)

Abstract Rationale: Up to 30% of COVID-19 patients experience persistent sequelae, including dyspnea, restrictive physiology, and early radiographic signs of pulmonary fibrosis (PF). The mechanisms that provoke post-COVID progressive PF are poorly understood, and biomarkers to identify at-risk patients are urgently needed. Methods: We evaluated a cohort of 14 symptomatic COVID survivors with impaired respiratory function and imaging worrisome for developing PF, including bilateral reticulation, traction bronchiectasis and/or honeycombing, and compared these to Idiopathic Pulmonary Fibrosis (IPF) patients and age-matched controls without respiratory disease. We performed single-cell RNA-sequencing and multiplex immunostaining on peripheral blood mononuclear cells collected at the COVID-19 patients’ first visit after ICU discharge. Six months later, symptoms, restriction and PF improved in some (Early-Resolving COVID PF), but persisted in others (Late-Resolving COVID PF). Results: Circulating monocytes were significantly reduced in Late-Resolving COVID PF patients compared to Early-Resolving COVID PF and non-diseased controls. Monocyte abundance correlated with pulmonary function tests FVC and DLCO. Differential expression analysis revealed MHC-II class molecules were upregulated on the CD8 T cells of Late-Resolving COVID PF patients but downregulated in monocytes. IPF patients had a similar decrease in monocyte abundance and marked decrease in monocyte HLA-DR protein expression compared to Late-Resolving COVID PF patients. Conclusion: Circulating monocyte abundance may distinguish between patients whose post-COVID PF resolves or persists. Furthermore, fibrotic progression coincided with decreases in HLA-DR expression on monocytes, a phenotype previously associated with dampened antigen stimulation and severe respiratory failure.
Characterization of pore-filling of spiro-MeOTAD in solid-state dye-sensitized solar cells and its consequence in device performance (2009)

In this paper, the pore filling of spiro-MeOTAD (2,2',7,7'-tetrakis-(N,N-di-p-methoxyphenylamine)9, 9'-spirobifluorene) in mesoporous TiO<sub>2</sub> films is quantified for the first time using XPS depth profiling and UVVis absorption spectroscopy. We show that spiro-OMeTAD can penetrate the entire depth of the film, and its concentration is constant throughout the film. We determine that in a 2.5-&bull;m-thick film, the volume of the pores is 60-65% filled. The pores become less filled when thicker films are used. Such filling fraction is much higher than the solution concentration because the excess solution on top of the film can act as a reservoir during the spin coating process. Lastly, we demonstrate that by using a lower spin coating speed and higher spiro-OMeTAD solution concentration, we can increase the filling fraction and consequently the efficiency of the device.
Comprehensive Understanding of the Spatial Configurations of CeO2 in NiO for the Electrocatalytic Oxygen Evolution Reaction: Embedded or Surface‐Loaded (2018)

Abstract Introducing cerium (Ce) species into electrocatalysts has been recently developed as an effective approach to improve their oxygen evolution reaction (OER) performance. Importantly, the spatial distribution of Ce species in the hosts can determine the availability of Ce species either as additives or as co‐catalysts, which would dictate their different contributions to the enhanced electrocatalytic performance. Herein, the comprehensive investigations on two different catalyst configurations, namely CeO 2 ‐embedded NiO (Ce‐NiO‐E) and CeO 2 ‐surface‐loaded NiO (Ce‐NiO‐L), are performed to understand the effect of their specific spatial arrangements on OER characteristics. The Ce‐NiO‐E catalysts exhibit a smaller overpotential of 382 mV for 10 mA cm −2 and a lower Tafel slope of 118.7 mV dec −1 , demonstrating the benefits of the embedded configuration for OER, as compared with those of Ce‐NiO‐L (426 mV and 131.6 mV dec −1 ) and pure NiO (467 mV and 140.7 mV dec −1 ), respectively. The improved OER property of Ce‐NiO‐E originates from embedding small‐sized CeO 2 clusters into the host for the larger specific surface area, richer surface defects, higher oxygen adsorption capacity, and better optimized electronic structures of the surface active sites, as compared with Ce‐NiO‐L. Above findings provide a valuable guideline for and insight in designing catalysts with different spatial configurations for enhanced catalytic properties.
Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (1985)

We have isolated and characterized overlapping clones from phage lambda and cosmid human genomic libraries that predict the entire structure of the gene encoding the precursor to human growth hormone-releasing factor. The gene includes five exons spanning 10 kilobase pairs of human genomic DNA. There appears to be a segregation of distinct functional regions of the GRF precursor and its mRNA into the five exons of the gene. The DNA sequences of all exons, intron/exon boundaries, and 5' and 3' flanking regions are presented. Dot-blot analysis of DNA from high resolution dual-laser-sorted human chromosomes indicates that the single-copy growth hormone-releasing factor gene is located on human chromosome 20.
Self-termination in the gas-phase layer-by-layer growth of an aza silane and water on planar silicon and nylon substrates (2014)

The authors report the gas phase, layer-by-layer deposition of an organosilane (N-n-butyl-aza-2,2-dimethoxysilacyclopentane, 1) and either water or aqueous ammonium hydroxide onto two substrates: Si/SiO2 and nylon. This process results in smooth, water resistant, inorganic-organic barrier layers. The layer-by-layer deposition of 1 appears to be self-limiting to a few nanometers, which may make it useful where ultrathin films of controllable dimensions and uniformity are desired. The authors are unaware of another thin film system that has these properties. Films were characterized by spectroscopic ellipsometry, water contact angle goniometry, x-ray photoelectron spectroscopy, and atomic force microscopy. Interestingly, film thicknesses on nylon were much higher than on silicon, and films prepared in the presence of the ammonia “catalyst” were thinner than those prepared with water. Test circuits coated only with a fluorosilane showed higher penetration of water compared to those coated with a barrier layer of 1/H2O and the fluorosilane.
Effects of image preprocessing/resizing on diagnostic quality of compressed medical images [chest radiographs application] (2002)

The effect of prefiltering and resizing on the diagnostic quality of compressed images at various compression ratios is examined in this paper. A key object of the work is to get an insight on selecting an optimal combination of resolution and quantizer coarseness for a given ratio of compression of medical images. Test images were decimated by several decimation factors, and compressed to achieve a target file size. The decompressed images were assessed for their diagnostic quality. The authors' results demonstrate two things: (1) the higher sampling rates allow a quality margin that may offset the effects of subsequent quantization; and (2) gains in quality due to higher resolution levels may eventually be outstripped by the degrading effects of compression as the compression ratio increases. The result suggests a more gradual reduction in resolution would provide better control over loss of quality.
Entrapment Into Nanoemulsions Potentiates the Anticancer Activity of Tocotrienols Against the Highly Malignant (+SA) Mouse Mammary Epithelial Cells (2014)

The highly malignant +SA mouse mammary epithelial cells were used as the model cell line over the years to establish the anticancer activity of tocotrienols. Tocotrienols, however, have poor oral bioavailability and were therefore entrapped into parenteral nanoemulsions for parenteral administration. The objective of this work was to test whether the activity of tocotrienols in lipid nanoemulsions against the +SA cells was retained. A secondary objective was to test whether stabilizing the nanoemulsions with poloxamer or sodium oleate would affect their activity. Nanoemulsions were found to be significantly more potent than tocotrienol/albumin conjugate. The IC50 values of the poloxamer and sodium oleate nanoemulsions were 3 and 6 microM, respectively, whereas the IC50 value of the conjugate was 10 microM. The antiproliferative activity of the nanoemulsions was also found to inversely correlate with particle size. No activity was observed with nanoemulsions loaded with alpha-tocopherol or vehicle, which confirmed the cytotoxic activity of tocotrienols and the potential use of nanoemulsions in cancer therapy.
Autocrine insulin‐like growth factor‐II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis†‡ (2008)

In human HCC cells, IGF-IR but not IR is involved in oncogenic IGF-II signaling. Autocrine stimulation of IGF-II induces HCC motility by integration of paracrine signals for full malignant competence. Thus, activation of IGF-II/IGF-IR signaling is likely a progression switch selected by function that promotes tumor cell dissemination and aggressive tumor behavior.
Narrowband Midinfrared Reflectance Filters Using Guided Mode Resonance (2010)

There is a need to develop mid-infrared (IR) spectrometers for applications in which the absorbance of only a few vibrational mode (optical) frequencies needs to be recorded; unfortunately, there are limited alternatives for the same. The key requirement is the development of a means to discretely access a small set of spectral positions from the wideband thermal sources commonly used for spectroscopy. We present here the theory, design, and practical realization of a new class of filters in the mid-infrared (IR) spectral regions based on using guided mode resonances (GMR) for narrowband optical reflection. A simple, periodic surface-relief configuration is chosen to enable both a spectral response and facile fabrication. A theoretical model based on rigorous coupled wave analysis is developed, incorporating anomalous dispersion of filter materials in the mid-IR spectral region. As a proof-of-principle demonstration, a set of four filters for a spectral region around the C-H stretching mode (2600-3000 cm(-1)) are fabricated and responses compared to theory. The reflectance spectra were well-predicted by the developed theory and results were found to be sensitive to the angle of incidence and dispersion characteristics of the material. In summary, the work reported here forms the basis for a rational design of filters that can prove useful for IR absorption spectroscopy.
A functional programming interpreter (2013)

Functional Programming (FP) sup BAC87 is an alternative to conventional imperative programming languages. This thesis describes an FP interpreter implementation. Superficially, FP appears to be a simple, but very inefficient language. Its simplicity, however, allows it to be interpreted quickly. Much of the inefficiency can be removed by simple interpreter techniques. This thesis describes the Illinois Functional Programming (IFP) interpreter, an interactive functional programming implementation which runs under both MS-DOS and UNIX. The IFP interpreter allows functions to be created, executed, and debugged in an environment very similar to UNIX. IFP's speed is competitive with other interpreted languages such as BASIC.
Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland (2018)

Finland provides unique opportunities to investigate population and medical genomics because of its adoption of unified national electronic health records, detailed historical and birth records, and serial population bottlenecks. We assembled a comprehensive view of recent population history (≤100 generations), the timespan during which most rare-disease-causing alleles arose, by comparing pairwise haplotype sharing from 43,254 Finns to that of 16,060 Swedes, Estonians, Russians, and Hungarians from geographically and linguistically adjacent countries with different population histories. We find much more extensive sharing in Finns, with at least one ≥ 5 cM tract on average between pairs of unrelated individuals. By coupling haplotype sharing with fine-scale birth records from more than 25,000 individuals, we find that although haplotype sharing broadly decays with geographical distance, there are pockets of excess haplotype sharing; individuals from northeast Finland typically share several-fold more of their genome in identity-by-descent segments than individuals from southwest regions. We estimate recent effective population-size changes through time across regions of Finland, and we find that there was more continuous gene flow as Finns migrated from southwest to northeast between the early- and late-settlement regions than was dichotomously described previously. Lastly, we show that haplotype sharing is locally enriched by an order of magnitude among pairs of individuals sharing rare alleles and especially among pairs sharing rare disease-causing variants. Our work provides a general framework for using haplotype sharing to reconstruct an integrative view of recent population history and gain insight into the evolutionary origins of rare variants contributing to disease.
Improved insulator/semiconductor interfaces in Al2O3/AlGaN/GaN structures by AlGaN layer regrowth (2019)

We investigated the effect of AlGaN regrown layer on the device characteristics of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /AlGaN/GaN metal-oxide-semiconductor high-electron-mobility transistors (MOS-HEMTs). From capacitance-voltage (C-V) investigations, it was confirmed that the quality of the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /AlGaN interfaces are improved by AlGaN regrowth as evidenced by negative shift of threshold voltage and the appearance of a second step in the C-V profile. Consequently, enhancement of transfer characteristic curves in terms of increased linearity and drain current density was also observed.
Comparison of the Permeation of MgCl2versus NaCl in Highly Charged Sulfonated Polymer Membranes (2011)

Sulfonated polymers have been considered for use as chlorine tolerant desalination membrane materials. The hydrophilic nature of these materials results from inclusion of sulfonate moieties on the polymer backbone. These sulfonate groups can dissociate into a fixed and a mobile ion. As such, ion exchange can occur when the polymer is contacted with an electrolyte solution. Different counter-ion forms of the same sulfonated polymer may exhibit very different transport properties. The sodium chloride permeability of a sulfonated pentablock copolymer increases as sodium chloride concentration in the upstream solution increases. However, the magnesium chloride permeability of the material does not show a strong dependence on salt concentration. These observations can be explained by Donnan theory and consideration of the effect of sodium and magnesium ions on the concentration of fixed charge groups in the polymer matrix. Greater association between magnesium ions and the polymer’s sulfonate groups reduces the effective fixed charge of the polymer, and Donnan exclusion becomes less effective compared to the sodium ion case.
Outdoor-to-Indoor Channel Dispersion and Power-Delay Profile Models for the 700-MHz and 4.9-GHz Bands (2015)

We present outdoor-to-indoor channel dispersion results based on measurements made in several representative urban environments. Root-mean-square delay spread values of less than 90 ns were extracted from measured power-delay profiles. We represent the power-delay profiles by exponential functions that can describe the multipath profiles for 700-MHz and 4.9-GHz frequency bands and extract a power-delay profile model for the 700-MHz band that utilizes seven taps.
Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects (2019)

Tebipenem pivoxil hydrobromide (TBPM-PI-HBr, formerly SPR994) is an orally available prodrug of tebipenem, a carbapenem with activity versus multidrug-resistant (MDR) Gram-negative pathogens, including quinolone-resistant and extended-spectrum-β-lactamase-producing <i>Enterobacteriaceae</i> The safety and pharmacokinetics (PK) of tebipenem were studied after administration of single and multiple ascending oral doses of TBPM-PI-HBr in fed and fasted states. Healthy adults received single oral doses of TBPM-PI-HBr at 100 mg to 900 mg or placebo (<i>n</i> = 108) or multiple doses of 300 mg or 600 mg every 8 h or placebo (<i>n</i> = 16) for 14 days. In the single-ascending-dose (SAD) phase, mean tebipenem plasma concentrations increased in a linear and dose proportional manner for doses of 100 to 900 mg and were comparable in the fasted and fed states for the 300- and 600-mg doses. In the MAD phase, tebipenem maximum concentration (<i>C</i><sub>max</sub>) was reached within 1.5 h and was dose proportional on day 1 and higher than dose proportional (2.7-fold) on day 14. AUC was more than 2-fold greater on day 1 (2.7-fold) and day 14 (2.5-fold) for 600 mg q8h than for 300 mg q8h. Approximately 55% to 60% of tebipenem was recovered in the urine. TBPM-PI-HBr was well tolerated; mild, transient diarrhea was the most commonly reported adverse event. TBPM-PI-HBr provides an orally bioavailable carbapenem option to treat serious infections caused by MDR <i>Enterobacteriaceae</i> and has the potential to decrease the need for intravenous antibiotic therapy in the hospital or outpatient setting. (This study has been registered at ClinicalTrials.gov under identifier NCT03395249.).
Mapping the Response of a Double-Sided Strip High-Purity Germanium Detector (2017)

We are developing a dual-headed small-animal SPECT system using double-sided strip IIPGe detectors. IIPGe provides superior energy resolution (approximately 1 % FWIIM at 140 keV), which allows for good scatter rejection and facilitates dualor multi-isotope imaging. Reconstructed images in our first prototype small-animal SPECT system exhibited artifacts, which we attributed to mis-positioning of events near the strip edges. To study the detector response and acquire data to facilitate the development of methods to recover multi-strip events, we have scanned a detector with a focused beam (approximately 25×25μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> @ 131 keV) at the Advanced Photon Source. These data showed dependencies with our position ratios (calculated using the fast signal from adjacent strips), the position of the beam on the strip, and the depth of interaction. Furthermore, the data also show position dependence of charge-shared events near and within the gap. We are using these data to develop an improved position estimation using maximum likelihood estimation that will to remove the spatial distortions and recover multi-strip events. We expect that this will lead to higher contrast and sensitivity in our SPECT images.
Clinical and Biochemical Presentation of Gouty Diathesis: Comparison of Uric Acid Versus Pure Calcium Stone Formation (1995)

The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment.
Politiques de la fusion (2016)

La multiplication récente des fusions dans les administrations publiques a alimenté une riche littérature sur les transformations des bureaucraties. À partir d’une perspective de process tracing déductif, cet article propose d’analyser les mécanismes de changement au cœur du vaste processus de réforme par fusion de l’administration territoriale de l’État en France (services déconcentrés des ministères et système préfectoral) de 2002 à 2008. En étudiant minutieusement les séquences de la réforme, il teste l’influence de quatre mécanismes explicatifs pour comprendre les mutations de l’État territorial à la française : le poids de l’exécutif politique sur les choix de structure ; la diffusion de formes organisationnelles légitimes ; le rôle d’entrepreneurs institutionnels dans les réorganisations ; l’influence des luttes bureaucratiques dans le redécoupage des frontières des administrations publiques.