gebhart/patrepeval huggingface dataset:
Effect of Interfacial Shear Strength on Impact Properties of Nb/MoSi<SUB>2</SUB> Laminate Composites (2000)

The relationship between the interfacial shear strength and the impact properties of Nb/MoSi2 laminate composites have been investigated, in conjunction with the evaluation of their fracture strain and the thickness of interfacial reaction layer. Nb/MoSi2 laminate composites have been fabricated by stacking sintered MoSi2 sheets and Nb sheets, alternately and hot pressing in the griphite mould. The instrumented Charpy impact test, the interfacial shear test and the tensile test was carried out at the room temperature. To change the interfacial shear strength associated with the thickness of interfacial reaction layer, Nb/MoSi2 laminate composites were fabricated as the parameter of hot press temperature. It is found that the interfacial shear strength between MoSi2 and Nb increases with the growth of the interfacial reaction layer, which results from the increase of fabricating temperature. Such a increase of the interfacial shear strength leads to a localized deformation of Nb foil and then deteriorates the enhancement of impact value in Nb/MoSi2 laminate composites. There is obviously an appropriate interfacial shear strength capable of maximizing the impact value in this composite system, associated with the plastic deformation of Nb foil.
REGIONAL PULSE WAVE VELOCITY AS PROGNOSTIC IMPACT IN HYPERTENSION: PP.2.56 (2010)

Background and Aim: Many groups including our group have shown pulse wave velocity (PWV), especially between carotid and femoral would be one of the prognostic factors for hypertensive patients. We can also evaluate heart-carotid PWV (hcPWV), heart-femoral PWV (hfPWV), femoral-ankle PWV (faPWV) and brachial-ankle PWV (baPWV) using carotid and femoral sensor of form PWV/ABI. Therefore we examined prognostic impact of each regional PWV on stroke and cardiovascular disease (CVD) in the cohort study of hypertensive patients. Method: This study is a sub-analysis of hospital-based cohort study, named NOn-invasive Atherosclerotic evaluation in Hypertension (NOAH) study (Terai M, et al. Hypertens Res 2008). The present study included 387 patients with essential hypertension (male/female = 218/169, mean age 61.1±11.8, mean follow period 43months; excluded ABI<0.9) whose regional PWV could be measured from October, 2000 to December, 2004. We set up stroke (n = 20) and CVD (n = 21) as a primary end point by the questionnaire. We classified the participants by the highest quartile of each PWV; high baPWV group, high hcPWV, high hfPWV and high faPWV; by the lowest quartile of ABI as low ABI group. Kaplan Meier analysis for stroke and CVD was performed by Logrank test. Result: There was a significant correlation between baPWV and regional PWV; faPWV (r = 0.560), hcPWV (r = 0.253) and hfPWV (r = 0.506). By Kaplan-Meier analysis, high baPWV group (p = 0.0020) and hfPWV (p = 0.0225) showed the prognostic impact of stroke and CVD but not high faPWV (p = 0.6982), high hcPWV (p = 0.5740) and low ABI group (p = 0.8008). High baPWV group showed the prognostic impact of both stroke (p = 0.0161) and CVD (0.0020), but high hfPWV only showed the prognostic impact of CVD (p = 0.0125). Moreover, only low ABI group showed the prognostic impact on mortality (p = 0.0231). Conclusion: As a further, larger, multicenter cohort study is needed, our study indicated that higher level of baPWV a might be a risk factor of stroke and CVD, but prognostic impact of other regional PWV is not still unclear in hypertension.
Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs (2004)

Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases. One of the most important compound families are quinazolines : e.g. the best inhibitor of EGFR tyrosine kinase is PD153035 (6,7-dimethoxy-4-(3'-bromophenyl)amino-quinazoline) and IRESSA (gefitinib, ZD1839), developed from this compound family, is presently the only one approved and granted drug by the FDA for the treatment of advanced non-small-cell lung cancer (NSCLC). KF31327 (3-ethyl-8-[2-(4-hydroxymethylpiperidino)benzylamino]-2,3-dihydro-1H-imidazo[4,5-g]-quinazoline-2-thione dihydrochloride) from this group, showed significantly higher inhibitory activity on cyclic GMP-specific phosphodiesterase compared with those of sildenafil (Viagra). The synthetic procedures of the example compounds are based on imidoyl chloride intermediates that were prepared from the appropriate 3H-quinazoline-4-ones. Although the key intermediates, quinazoline-4-ones, have been known since more than hundred years, their synthetic procedures have been improved much only in the past ten years. In this paper we reviewed the efficient synthetic methods of quinazolin-4-ones, and presented a novel, reliable method for their synthesis. There was no considerable effect of microwave-, or traditional thermal activation on the yield and compound purity.
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse (2000)

Two G protein-coupled receptors have been identified that bind corticotropin-releasing factor (CRF) and urocortin (UCN) with high affinity. Hybridization histochemical methods were used to shed light on controversies concerning their localization in rat brain, and to provide normative distributional data in mouse, the standard model for genetic manipulation in mammals. The distribution of CRF-R1 mRNA in mouse was found to be fundamentally similar to that in rat, with expression predominating in the cerebral cortex, sensory relay nuclei, and in the cerebellum and its major afferents. Pronounced species differences in distribution were few, although more subtle variations in the relative strength of R1 expression were seen in several forebrain regions. CRF-R2 mRNA displayed comparable expression in rat and mouse brain, distinct from, and more restricted than that of CRF-R1. Major neuronal sites of CRF-R2 expression included aspects of the olfactory bulb, lateral septal nucleus, bed nucleus of the stria terminalis, ventromedial hypothalamic nucleus, medial and posterior cortical nuclei of the amygdala, ventral hippocampus, mesencephalic raphe nuclei, and novel localizations in the nucleus of the solitary tract and area postrema. Several sites of expression in the limbic forebrain were found to overlap partially with ones of androgen receptor expression. In pituitary, rat and mouse displayed CRF-R1 mRNA signal continuously over the intermediate lobe and over a subset of cells in the anterior lobe, whereas CRF-R2 transcripts were expressed mainly in the posterior lobe. The distinctive expression pattern of CRF-R2 mRNA identifies additional putative central sites of action for CRF and/or UCN. Constitutive expression of CRF-R2 mRNA in the nucleus of the solitary tract, and stress-inducible expression of CRF-R1 transcripts in the paraventricular nucleus may provide a basis for understanding documented effects of CRF-related peptides at a loci shown previously to lack a capacity for CRF-R expression or CRF binding. Other such "mismatches" remain to be reconciled.
Adventures in Supersingularland (2021)

In this paper, we study isogeny graphs of supersingular elliptic curves. Supersingular isogeny graphs were introduced as a hard problem into cryptography by Charles, Goren, and Lauter for the construction of cryptographic hash functions [CGL06]. These are large expander graphs, and the hard problem is to find an efficient algorithm for routing, or path-finding, between two vertices of the graph. We consider four aspects of supersingular isogeny graphs, study each thoroughly and, where appropriate, discuss how they relate to one another. First, we consider two related graphs that help us understand the structure: the `spine' $\mathcal{S}$, which is the subgraph of $\mathcal{G}_\ell(\overline{\mathbb{F}_p})$ given by the $j$-invariants in $\mathbb{F}_p$, and the graph $\mathcal{G}_\ell(\mathbb{F}_p)$, in which both curves and isogenies must be defined over $\mathbb{F}_p$. We show how to pass from the latter to the former. The graph $\mathcal{S}$ is relevant for cryptanalysis because routing between vertices in $\mathbb{F}_p$ is easier than in the full isogeny graph. The $\mathbb{F}_p$-vertices are typically assumed to be randomly distributed in the graph, which is far from true. We provide an analysis of the distances of connected components of $\mathcal{S}$. Next, we study the involution on $\mathcal{G}_\ell(\overline{\mathbb{F}_p})$ that is given by the Frobenius of $\mathbb{F}_p$ and give heuristics on how often shortest paths between two conjugate $j$-invariants are preserved by this involution (mirror paths). We also study the related question of what proportion of conjugate $j$-invariants are $\ell$-isogenous for $\ell = 2,3$. We conclude with experimental data on the diameters of supersingular isogeny graphs when $\ell = 2$ and compare this with previous results on diameters of LPS graphs and random Ramanujan graphs.
Multiple metal-carbon bonds. 40. Reaction of Mo(CCMe3)[OCH(CF3)2]3(dimethoxyethane) with tert-butylacetylene, an aborted acetylene polymerization (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 40. Reaction of Mo(CCMe3)[OCH(CF3)2]3(dimethoxyethane) with tert-butylacetylene, an aborted acetylene polymerizationH. Strutz, J. C. Dewan, and R. R. SchrockCite this: J. Am. Chem. Soc. 1985, 107, 21, 5999–6005Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ja00307a026https://doi.org/10.1021/ja00307a026research-articleACS PublicationsRequest reuse permissionsArticle Views360Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Antitumor Cellular Vaccine Based on a Mini-Membrane IgE (2011)

The IgE-mediated immune system activation can be redirected to combat tumors. Mouse and human IgE have been shown to provide a potent adjuvant effect in antitumor vaccination, with a crucial role played by FcεRI. This effect results from T cell-mediated adaptive immune response. Modified vaccinia virus Ankara (MVA) has been used to infect IgE-loaded tumor cells. These results led to a shift toward a highly safe protocol employing membrane IgE (mIgE), thus eliminating any possible anaphylactogenicity caused by circulating IgE. Evidence that human mIgE and a truncated version lacking IgE Fabs (tmIgE) bind and activate FcεRI has been fundamental and forms the core of this report. Human tmIgE has been engineered into a recombinant MVA (rMVA-tmIgE), and the expression of tmIgE and its transport to the surface of rMVA-tmIgE-infected cells has been detected by Western blot and cytofluorimetry, respectively. FcεRI activation by tmIgE has been confirmed by the release of β-hexosaminidase in a cell-to-cell contact assay using human FcεRI-transfected RBL-SX38 cells. The rMVA-tmIgE antitumor vaccination strategy has been investigated in FcεRIα(-/-) human FcεRIα(+) mice, with results indicating a level of protection comparable to that obtained using soluble human IgE tumor cell loading. The rMVA-tmIgE vector represents a device that suits safe IgE-based antitumor vaccines, harboring the possibility to couple tmIgE with other gene insertions that might enhance the antitumor effect, thus bringing the field closer to the clinics.
HTS Identifies Novel and Specific Uncompetitive Inhibitors of the Two-Component NS2B-NS3 Proteinase of West Nile Virus (2007)

West Nile virus (WNV), a member of the Flavividae family, is a mosquito-borne, emerging pathogen. In addition to WNV, the family includes dengue, yellow fever, and Japanese encephalitis viruses, which affect millions of individuals worldwide. Because countermeasures are currently unavailable, flaviviral therapy is urgently required. The flaviviral two-component nonstructural NS2B-NS3 proteinase (protease [pro]) is essential for viral life cycle and, consequently, is a promising drug target. We report here the results of the miniaturization of an NS2B-NS3pro activity assay, followed by high-throughput screening of the National Institutes of Health's 65,000 compound library and identification of novel, uncompetitive inhibitors of WNV NS2B-NS3pro that appear to interfere with the productive interactions of the NS2B cofactor with the NS3pro domain. We anticipate that following structure optimization, the identified probes could form the foundation for the design of novel and specific therapeutics for WNV infection. We also provide the structural basis for additional species-selective allosteric inhibitors of flaviviruses.
Selatogrel, the reversible and specific P2Y12 receptor antagonist, does not interfere with haemostasis (2020)

Abstract Background Combination of a P2Y12 receptor (P2Y12R) antagonist (clopidogrel, prasugrel, ticagrelor) with aspirin is the recommended standard of care for patients with acute coronary syndrome. Selatogrel is a reversible and potent antagonist of P2Y12R. Interestingly, in an experimental thrombosis model in rat, at equivalent antithrombotic effect, blood loss was lower in the presence of selatogrel, compared with clopidogrel or ticagrelor. Purpose To characterise the lower risk of bleeding previously observed with selatogrel Methods Mechanistic studies were performed to profile laser-induced thrombosis in wild-type and P2Y12 deficient mice with real-time intravital microscopy. Ticagrelor and clopidogrel were used as selatogrel comparators. Results Selatogrel, ticagrelor and clopidogrel dose-dependently inhibited laser-induced platelet thrombus formation. At maximal antithrombotic effect, only small mural platelets aggregates, corresponding to the haemostatic seals, were present. The phenotype of these haemostatic seals depended on the P2Y12R antagonist used. In the presence of clopidogrel or ticagrelor, the stability of haemostatic seals was reduced. In contrast, in the presence of selatogrel, the apparent stability was not disturbed. Moreover, equivalent antithrombotic dosing regimens of ticagrelor and clopidogrel interfered with laser-induced calcium mobilisation in the endothelium, restricted subsequent neutrophil adhesion and thus reduced fibrin-mediated stabilisation of the haemostatic seals in wild type mice. The effects of ticagrelor were also observed in P2Y12R-deficient mice, indicating that the effects are P2Y12R independent and off-target. In contrast, an equivalent antithrombotic dosing regimen of selatogrel did not interfere with the process of haemostasis in wild-type or P2Y12R-deficient mice. The degree of interference with the stability of the haemostatic seals correlated with the blood loss profile. The dosing regimens of clopidogrel and ticagrelor, corresponding to the equivalent antithrombotic effects, induced a more pronounced increase in blood loss than that observed with selatogrel. Conclusion Our data offer a novel mechanistic explanation for the differences in bleeding risk of clopidogrel, ticagrelor and selatogrel. Clopidogrel and ticagrelor were found to interfere with haemostasis due to off-target activities. In contrast, selatogrel did not interfere with haemostasis in wild-type and P2Y12-deficient mice, inferring that the process of haemostasis, as defined by formation of haemostatic seals, is independent of P2Y12R. In addition, our data emphasize that the absence of interference with haemostasis is paramount to preserve the advantage of P2Y12R antagonism. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Idorsia Pharmaceuticals Ltd. Allschwil, Switzerland
Power deposition properties of a travelling-wave applicator for interstitial hyperthermia (1992)

A permittivity of (51-j31) has been used which is typical of muscle, skin and other tissue having high water content [2) at the frequencies considered here (915 MHz). The radiator has been modeled as a lossy transmission line with empirically determined characteristics. Figures 2 and 3 show the power density along a line parallel to the axis of the applicator at various radial distances with the diode biased on. The rapid rate of decay with radial distance could be reduced by operating at a lower frequency. Figure 4 illustrates the movement of the peak power density as the diodes are switched on or off. In Figure 5 the length of the applicator has been increased to one half wavelength. The two modes are shown to provide uniform heating over a 6 cm range of depth
ChemInform Abstract: Lipophilic Cage Ligands Containing Two Tightly Connected 1,7‐Dioxa‐4,10‐diazacyclododecane Rings: Synthesis and X‐Ray Structure of a Sodium Perchlorate Complex. (1989)

Abstract 4‐Tosyl‐1,7‐dioxa‐4,10‐diazacyclododecane (VII), prepared from the chloroethoxyethanol (I) and p‐toluenesulfonamide (II), is converted into the propanediyl‐bis(dioxadiazacyclododecanes) (X) which undergo sodium‐templated cyclocondensation with the bissulfonates (XI), yielding the sodium perchlorate complexes (XIII).
The design of inverter power system for plasma generator (2005)

A sterilizer equipment by using electrical energy has merits that have no process of chemical and no second environmental pollution. Moreover, the power conversion circuit for sterilizer equipment has merits that are reducing switching loss for soft switching topology by using zero current and zero voltage switching, and miniaturizing size of equipment. The proposed power device which has lower output current than other devices is possible to be compacted in its size and reduced its price if the proposed power device is used for power system. Therefore, it is adapted for both less power consumption and sudden power conversion.
Three‐Component Enantioselective Synthesis of Propargylamines Through Zr‐Catalyzed Additions of Alkyl Zinc Reagents to Alkynylimines. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Substrate Dependence of Conformational Changes in the RNA-Binding Domain of Tristetraprolin Assessed by Fluorescence Spectroscopy of Tryptophan Mutants (2006)

Association of tristetraprolin (TTP) with mRNAs containing selected AU-rich mRNA-destabilizing elements (AREs) initiates rapid cytoplasmic degradation of these transcripts. The RNA-binding activity of TTP is mediated by an internal tandem zinc finger domain that preferentially recognizes U-rich RNA ligands containing adjacent UUAU half-sites and is accompanied by conformational changes within the peptide. Here, we have used analogues of the TTP RNA-binding domain containing specific tryptophan substitutions to probe the Zn2+ and RNA substrate dependence of conformational events within individual zinc fingers. Fluorescence methods demonstrate that the N-terminal, but not C-terminal, zinc finger domain adopts a stably folded conformation in the presence of Zn2+. Denaturant titrations suggest that both the N- and C-terminal zinc fingers exhibit limited structural heterogeneity in the absence of RNA substrates, although this is more pronounced for the C-terminal finger. Binding to a cognate ARE substrate induced significant conformational changes within each zinc finger, which also included increased resistance to chemical denaturation. Studies with mutant ARE ligands revealed that a single UUAU half-site was sufficient to induce structural modulation of the N-terminal finger. However, RNA-dependent folding of the C-terminal zinc finger was only observed in the presence of tandem UUAU half-sites, suggesting that the conformation of this domain is linked not only to RNA substrate recognition but also to the ligand occupancy and/or conformational status of the N-terminal finger. Coupled with previous structural and thermodynamic analyses, these data provide a mechanistic framework for discrimination of RNA substrates involving ligand-dependent conformational adaptation of both zinc fingers within the TTP RNA-binding domain.
Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors (2012)

The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified the pyrazolo[1,5-a]pyrimidine scaffold as a potent inhibitor of Jak2. Optimization of lead compounds 7a-b and 8 in this chemical series for activity against Jak2, selectivity against other Jak family kinases, and good in vivo pharmacokinetic properties led to the discovery of 7j. In a SET2 xenograft model that is dependent on Jak2 for growth, 7j demonstrated a time-dependent knock-down of pSTAT5, a downstream target of Jak2.
ACTH-Independent Cushing’s Syndrome with Bilateral Micronodular Adrenal Hyperplasia and Ectopic Adrenocortical Adenoma (2009)

This case suggests that unknown molecular defects can favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma associated with Cushing's syndrome.
Fibrous Nanozyme Dressings with Catalase-Like Activity for H2O2 Reduction To Promote Wound Healing (2017)

The concentrations of the redox pair hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and oxygen (O<sub>2</sub>) can promote or decelerate the progression and duration of the wound healing process. Although H<sub>2</sub>O<sub>2</sub> can reach critically high concentrations and prohibit healing, a sufficient O<sub>2</sub> inflow to the wound is commonly desired. Herein, we describe the fabrication and use of a membrane that can contemptuously decrease H<sub>2</sub>O<sub>2</sub> and increase O<sub>2</sub> levels. Therefore, hematite nanozyme particles were integrated into electrospun and cross-linked poly(vinyl alcohol) membranes. Within the dual-compound membrane, the polymeric mesh provides a porous scaffold with high water permeability and the nanozymes act as a catalyst with catalase-like activity that can efficiently convert H<sub>2</sub>O<sub>2</sub> into O<sub>2</sub>, as shown by a catalase assay. When comparing the growth of fibroblasts at an H<sub>2</sub>O<sub>2</sub> concentration of 50 μM, the growth was largely enhanced when applying the nanozyme dressing. Thus, application of the nanozyme dressing can significantly reduce the harmful effect of higher H<sub>2</sub>O<sub>2</sub> concentrations. The described catalytic membranes could be used in the future to provide an improved environment for cell proliferation in wounds and thus applied as advanced wound healing dressings.
Theory-Informed Interventions to Improve the Quality of Tuberculosis Evaluation at Ugandan Health Centers: A Quasi-Experimental Study (2015)

Performance feedback and same-day microscopy should be considered along with ISTC training as part of a multi-faceted intervention to improve the quality of TB evaluation in other high TB burden countries.