gebhart/patrepeval huggingface dataset:
Evaluation of Tubular Poly(Trimethylene Carbonate) Tissue Engineering Scaffolds in a Circulating Pulsatile Flow System (2011)

Tubular scaffolds (internal diameter approximately 3 mm and wall thickness approximately 0.8 mm) with a porosity of approximately 83% and an average pore size of 116 µm were prepared from flexible poly(trimethylene carbonate) (PTMC) polymer by dip-coating and particulate leaching methods. PTMC is a flexible and biocompatible polymer that crosslinks upon irradiation; porous network structures were obtained by irradiating the specimens in vacuum at 25 kGy before leaching soluble salt particles. To assess the suitability of these scaffolds in dynamic cell culturing for cardiovascular tissue engineering, the scaffolds were coated with a thin (0.1 to 0.2 mm) non-porous PTMC layer and its performance was evaluated in a closed pulsatile flow system (PFS). For this, the PFS was operated at physiological conditions at liquid flows of 1.56 ml/s with pressures varying from 80-120 mmHg at a frequency of 70 pulsations per minute. The mechanical properties of these coated porous PTMC scaffolds were not significantly different than non-coated scaffolds. Typical tensile strengths in the radial direction were 0.15 MPa, initial stiffness values were close to 1.4 MPa. Their creep resistance in cyclic deformation experiments was excellent. In the pulsatile flow setup, the distention rates of these flexible and elastic scaffolds were approximately 0.10% per mmHg, which is comparable to that of a porcine carotid artery (0.11% per mmHg). The compliance and stiffness index values were close to those of natural arteries.?In long-term deformation studies, where the scaffolds were subjected to physiological pulsatile pressures for one week, the morphology and mechanical properties of the PTMC scaffolds did not change. This suggests their suitability for application in a dynamic cell culture bioreactor.
A Comparison of Two Control-Display Gain Measures for Head-Controlled Computer Input Devices (1996)

We compared two gain measures: One, defined as angle/angle (A/A) gain, is the ratio between the angle subtended by displacement of the cursor and the corresponding angle of head extension/flexion or rotation. The alternative measure, defined as displacement/angle (D/A) gain, is the ratio between the linear displacement of the cursor on the screen and the corresponding angle of head extension/ flexion or rotation. A discrete target acquisition task using circular targets was used to compare control-display gain measures. Operator performance was evaluated for three viewing distances and three gain settings of each measure. Average movement time and root mean squared (RMS) cursor deviation from a straight line path increased as viewing distance increased for A/A gain settings 0.75 and 1.0. That no significant distance effect was observed for any of the D/A gain settings indicated that it might be more suitable to fix D/A gain rather than A/A gain for head-controlled computer input devices. Minimum movement time occurred for D/A gain settings of 0.5 cm/degree and 0.67 cm/degree. One explanation for the observed insensitivity of performance to changes in viewing distance with a fixed D/A gain may be that both angular head movement and the accompanying kinesthetic feedback do not change for a specified cursor displacement as viewing distance is changed.
Advanced and Feasible Signal Processing Algorithm for Nonlinear Mitigation (2013)

Implementation-efficient nonlinear mitigation algorithms for digital coherent transceivers are introduced. Q-improvement by different algorithm combinations is presented for different transmission scenarios. Expectations on further improvement thorough noise reshaping and cycle slip reduction are also addressed.
Quantifying Longitudinal Patterns and Trends of Objectively Measured Physical Activity Across the Age Spectrum (2016)

PURPOSE: Physical activity is fundamental to maintaining health and functional status with aging. Accelerometers present new opportunities to define and quantify daily physical activity in older adults, and to better understand the associations among physical activity and health-related outcomes. The objective of this study was to examine the onset and magnitude of the age-related decline in physical activity, and corresponding changes in circadian patterns of activity, in a large cohort of well functioning adults. METHODS: Physical activity was assessed in 308 participants (mean age 70.0, range 38 – 95, 47% male) in the Baltimore Longitudinal Study of Aging (BLSA) over a 7-day period using the Actiheart, a unidirectional chest-worn accelerometer. Activity was recorded in one-minute activity count epochs, a composite measure of physical activity intensity and duration. The primary outcome was physical activity decline over a mean three-year period (range 1-6 yrs). The association between the log of physical activity counts and age was modeled using linear regression models with generalized estimating equations for repeated measures, adjusted for age, sex, BMI, race, education, employment, functional status, and history of chronic conditions. RESULTS: In fully adjusted population average models, physical activity declined 1.6% per year (p < 0.001). The decline was attenuated in those currently employed and those with better functional status (p < 0.001), but accelerated in participants with higher BMI and those with a history of stroke (p < 0.01). Those who declined were older, more likely to be male, and to have had a history of stroke and peripheral neuropathy at baseline (p < 0.05). In models stratified by age and time-of day, the greatest decline occurred among those aged 75 and older (n = 90), specifically in the morning hours (8-12 am) (p = 0.02). CONCLUSIONS: Among well functioning, community-dwelling older adults, age-related decline in physical activity is exacerbated by the presence of chronic conditions. Such decline is most evident in the morning hours, when volitional daily activity is typically highest. Use of accelerometers that can generate detailed data on activity patterns throughout the day may provide useful information for effective interventions for maintaining activity later into life.
(Invited) Metal Oxide Thin-Film Transistors with Deep Submicron Channel Enabled By Self-Aligned Nano Gap Patterning (2022)

We demonstrate the fabrication technology of metal oxide semiconductor thin-film transistors (TFTs) with deep submicron channel length and their electrical characterization. We call the method as self-aligned nano gap patterning (SANP), where the pattern resolution is limited not by optical diffraction in photolithography, but by the details in etching and deposition process. Therefore, this makes it enable to overcome the obstacle in the scale down of large area electronic devices, for which high resolution photolithography tools such as VUV or XUV used in semiconductor industry are almost useless due to the extremely low throughput and high cost. In this work, we employ the contact aligner with line and space resolution of 3 μm, and the oxides TFTs with 0.1μm channel length was successfully fabricated with field-effect mobility of 12 cm 2 /Vs, subthreshold swing of 100 mV/dec, I on /I off of 10 10 , and turn-on voltage of -0.88 V.
Acceleration of Lung Regeneration by Platelet-Rich Plasma Extract through the Low-Density Lipoprotein Receptor–Related Protein 5–Tie2 Pathway (2015)

Angiogenesis, the growth of new blood vessels, plays a key role in organ development, homeostasis, and regeneration. The cooperation of multiple angiogenic factors, rather than a single factor, is required for physiological angiogenesis. Recently, we have reported that soluble platelet-rich plasma (PRP) extract, which contains abundant angiopoietin-1 and multiple other angiogenic factors, stimulates angiogenesis and maintains vascular integrity in vitro and in vivo. In this report, we have demonstrated that mouse PRP extract increases phosphorylation levels of the Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) and thereby activates angiogenic factor receptor Tie2 in endothelial cells (ECs) and accelerates EC sprouting and lung epithelial cell budding in vitro. PRP extract also increases phosphorylation levels of Tie2 in the mouse lungs and accelerates compensatory lung growth and recovery of exercise capacity after unilateral pneumonectomy in mice, whereas soluble Tie2 receptor or Lrp5 knockdown attenuates the effects of PRP extract. Because human PRP extract is generated from autologous peripheral blood and can be stored at -80°C, our findings may lead to the development of novel therapeutic interventions for various angiogenesis-related lung diseases and to the improvement of strategies for lung regeneration.
Role of Spleen in Choline Stimulation of Reticuloendothelial System and Resistance to Acute Hemorrhage (1978)

Experiments were undertaken, with rats, to determine whether the spleen plays a role in choline chloride-induced reticuloendothelial system (RES) phagocytic stimulation and protection against circulatory shock. Choline pretreatment of normal, intact, but not splenectomized rats, resulted in heightened RES phagocytic stimulation and protection against acute hemorrhagic shock. Choline pretreatment significantly increased spleen size in normal intact rats. Wet liver or lung weights were not significantly affected by choline pretreatment of either normal or splenectomized rats. Untreated, splenectomized animals did not demonstrate any significant alterations in either RES phagocytic activity or RE organ wet weights when compared to normal, intact controls or to sham-operated animals. Although the results of these experiments make it clear that the presence of a functioning spleen is necessary for choline-induced RES stimulation and shock protection, it is not clear as to just how these actions are brought about. Further exploration is warranted in view of the clinical implications of these findings.
Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation (2020)

(-)-Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6-step synthesis of (-)-finerenone, which features an enantioselective partial transfer hydrogenation of a naphthyridine using a chiral phosphoric acid catalyst with a Hantzsch ester. The process is complicated by the fact that the naphthyridine exists as a mixture of two atropisomers that react at different rates and with different selectivities. The intrinsic kinetic resolution was converted into a kinetic dynamic resolution at elevated temperature, which enabled us to obtain (-)-finerenone in both high yield and high enantioselectivity. DFT calculations have revealed the origin of selectivity.
Simplified non-uniform constellation demapping scheme for the next broadcasting system (2015)

This paper proposes a simplified non-uniform constellation (NUC) demapping scheme for the next generation broadcasting systems which adopt NUC as an advanced modulation technique. The proposed scheme provides a reduced demapping complexity by considering only effective bits within a modulated symbol while the performance loss is negligible.
Treatment of Wilson’s disease: our patients deserve better (2014)

This editorial represents my opinion on the best management of treatment for Wilson’s disease (WD) following 40 years of experience.Unlike many rare inherited diseases, there are multiple effective...
One pot synthesis of bioactive benzopyranones through palladium-catalyzed C–H activation and CO insertion into 2-arylphenols (2013)

Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.
Synthese von Aminobenzothiazolderivaten mit unterschiedlichen fluorhaltigen Piperidin- und Piperazin-Substituenten für die PET-Bildgebung des Adenosin-A 2A -Rezeptors (2020)

Ziel/Aim Eine Veränderung der A2AR-Expression im menschlichen Gehirn ist häufig mit neurodegenerativen Erkrankungen verbunden. A2AR-Konzentrationsänderungen auf molekularer Ebene können mit A2AR-spezifischen Radioliganden potenziell visualisiert werden.(1) Im Rahmen dieses Projektes wurde eine Reihe von sieben fluorierten Aminobenzothiazolderivaten, die sich potenziell für PET-Diagnostik eignen, synthetisiert.
No Reservations: A First Look at Amazon's Reserved Instance Marketplace (2020)

Cloud users can significantly reduce their cost (by up to 60\%) by reserving virtual machines (VMs) for long periods (1 or 3 years) rather than acquiring them on demand. Unfortunately, reserving VMs exposes users to \emph{demand risk} that can increase cost if their expected future demand does not materialize. Since accurately forecasting demand over long periods is challenging, users often limit their use of reserved VMs. To mitigate demand risk, Amazon operates a Reserved Instance Marketplace (RIM) where users may publicly list the remaining time on their VM reservations for sale at a price they set. The RIM enables users to limit demand risk by either selling VM reservations if their demand changes, or purchasing variable- and shorter-term VM reservations that better match their demand forecast horizon. Clearly, the RIM's potential to mitigate demand risk is a function of its price characteristics. However, to the best of our knowledge, historical RIM prices have neither been made publicly available nor analyzed. To address the problem, we have been monitoring and archiving RIM prices for 1.75 years across all 69 availability zones and 22 regions in Amazon's Elastic Compute Cloud (EC2). This paper provides a first look at this data and its implications for cost-effectively provisioning cloud infrastructure.
LED-based projection source based on luminescent concentration (2016)

The concept of an LED-based source with high lumen density is described. It contains a luminescent rod in which LED light is converted to light with a longer wavelength that is extracted from a small face of the rod. The fundamental limitations and possibilities are discussed, as well as the constituents needed. Results are shown for two realized high lumen density sources. A source with YAG:Ce as phosphor is extensively characterized and the results are compared to modeling results. A source with an optimized green emitting phosphor is used for projection. With 64 pump LEDs at 490 W peak electrical input and 50% duty cycle, a peak luminous flux of 18000 lm and a peak luminance of over 1000 cd/mm<sup>2</sup> is obtained, with an efficacy of 37 peak lm/W.
Ovarian Carcinoma Expresses the NKG2D Ligand Letal and Promotes the Survival and Expansion of CD28− Antitumor T Cells (2004)

The role of the NKG2D immunoreceptor and its ligands in antitumor immune response is incompletely understood. Here, we report that effector immune cells infiltrating ovarian carcinoma are mostly CD8+ lymphocytes lacking CD28 but expressing the NKG2D costimulatory receptor. Human ovarian carcinoma expresses the novel NKG2D ligand lymphocyte effector cell toxicity-activating ligand (Letal). Letal was found to be an independent prognosticator of improved survival in advanced ovarian cancer. Higher levels of tumor-derived Letal were associated with stronger lymphocyte infiltration. Letal exerted marked costimulatory effects and induced type-1 polarization in CD8+CD28- tumor-infiltrating lymphocytes ex vivo. Letal engagement increased the expression of the glucose transporter Glut-1, enhanced glucose up-take, and protected CD8+ lymphocytes from cisplatin-induced killing. Letal also down-regulated the expression of Fas in CD8+ cells and rendered them resistant to Fas ligand-induced apoptosis. Our results indicate that Letal promotes tumor immune surveillance by promoting the survival and intratumoral expansion of antitumor cytotoxic lymphocytes. We propose that Letal could be used for the ex vivo expansion of apoptosis-resistant tumor-reactive cytotoxic lymphocytes for adoptive transfer.
Early Detection of an Underperforming Implantable Cardiovascular Device Using an Automated Safety Surveillance Tool (2012)

An active automated safety surveillance system could have identified this implantable cardiovascular device problem substantially sooner than was achieved through existing postmarket surveillance methods. Such a tool, when applied to clinical registries and remote monitoring databases, may limit the exposure of large populations to underperforming and potentially hazardous cardiovascular devices.
Early Return to Surgery for Evacuation of a Postoperative Hematoma After Primary Total Knee Arthroplasty (2008)

Patients who return to the operating room within thirty days after the index total knee arthroplasty for evacuation of a postoperative hematoma are at significantly increased risk for the development of deep infection and/or undergoing subsequent major surgery. These results support all efforts to minimize the risk of postoperative hematoma formation.
Optical Coherence Tomography (OCT) for Automatic Registration in Spinal Surgery (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Hauger, W. Pöltinger, T. Mergenthaler, V. Braun, O. Schneider, and A. Schneider, "Optical Coherence Tomography (OCT) for Automatic Registration in Spinal Surgery," in Biomedical Optics, OSA Technical Digest (Optica Publishing Group, 1999), paper JWA4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Enabling UTBB Strained SOI Platform for Co-Integration of Logic and RF: Implant-Induced Strain Relaxation and Comb-Like Device Architecture (2020)

For the first time, ion implant was used to partially relax the tensile strain by half in the fully-depleted (FD) strained SOI (SSOl) so that SiGe pFETs with a higher compressive strain can be realized at a fixed Ge composition. This enables the co-integration of highly tensile-strained Si nFETs and compressive-strained SiGe pFETs on the same substrate, achieving significant improvement in electrical performance over the unstrained counterpart verified by both experiment and simulation results. We also propose a Comb-like strained SOI architecture to further boost RF performance, demonstrating peak G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> improved by 47% over unstrained n-type FinFET SOI, as well as an improvement of 22% and 36% for f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> , respectively, over n-type FinFETs SSOI.
Three-dimensional OCT imaging of the embryonic chick heart (2003)

Optical coherence tomography (OCT) is a powerful new high resolution imaging modality which can provide new insight into normal and abnormal cardiac development in animal models. Here we demonstrate for the first time the application of OCT for three-dimensional imaging of the developing cardiovascular system of the chick embryo. Using this three-dimensional data, we compared cross-sectional OCT images with histological cross-sections and we generated volumetric reconstructions of the early heart tube.
Performance of Whole-Cell Electrochemical Biosensor Using Integrated Microbes/Si Nano-Forest Structure (2016)

A new structure, integrating microbial cells on Si nano-forest, combines whole cell biosensors with a functional nanostructured electrode is described in the current work. E.Coli microbes that expressed and displayed recombinant ZZ proteins were immobilized to a functionalized electrode using IgG antibodies. The presence of E.Coli cells was verified visually and electrochemically using scanning electron microscopy and impedance spectroscopy, respectively. Such structure produces unique electrochemical impedance spectrum that was affected by the analyte concentration. That signal, which is analyzed by both Nyquist diagram and the Bode plot, provide a proof of concept for the feasibility of such integrated whole cell biosensor. Moreover, the selectivity of the system was also confirmed using control cells displaying proteins different form ZZ.
Aircraft Vibration Detection and Diagnosis for Predictive Maintenance using a GLR Test (2018)

International audience
“Grip-that-there”: An Investigation of Explicit and Implicit Task Allocation Techniques for Human-Robot Collaboration (2021)

In ad-hoc human-robot collaboration (HRC), humans and robots work on a task without pre-planning the robot's actions prior to execution; instead, task allocation occurs in real-time. However, prior research has largely focused on task allocations that are pre-planned - there has not been a comprehensive exploration or evaluation of techniques where task allocation is adjusted in real-time. Inspired by HCI research on territoriality and proxemics, we propose a design space of novel task allocation techniques including both explicit techniques, where the user maintains agency, and implicit techniques, where the efficiency of automation can be leveraged. The techniques were implemented and evaluated using a tabletop HRC simulation in VR. A 16-participant study, which presented variations of a collaborative block stacking task, showed that implicit techniques enable efficient task completion and task parallelization, and should be augmented with explicit mechanisms to provide users with fine-grained control.
Analysis of reverse tunnelling current in GaInN light-emitting diodes (2010)

The characteristics of the reverse leakage current of GaInN/GaN multiple quantum well light-emitting diodes (LEDs) are examined with various n-type GaN doping concentrations and interpreted by using a tunnelling current model. Changing the doping concentration of the n-type GaN influences the tunnelling probability of electrons into the conduction band and thus the reverse leakage current. Reducing the doping concentration of the top 150 nm portion of the n-type GaN layer by half decreases the tunnelling probability, resulting in decrease of the reverse leakage current by 80% at −10 V without deterioration of any forward electrical properties of LEDs.