gebhart/patrepeval huggingface dataset:
High-pressure phase equilibria in ternary systems of propionic acid and water with ethane, sulfur hexafluoride or refrigerant 13 (chlorotrifluoromethane), 23 (trifluoromethane), or 116 (hexafluoroethane) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-pressure phase equilibria in ternary systems of propionic acid and water with ethane, sulfur hexafluoride or refrigerant 13 (chlorotrifluoromethane), 23 (trifluoromethane), or 116 (hexafluoroethane)Richard C. Willson, Athanassios Z. Panagiotopoulos, and Robert C. ReidCite this: J. Chem. Eng. Data 1991, 36, 3, 290–293Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/je00003a010https://doi.org/10.1021/je00003a010research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessing <i>In Vitro</i> Degradation of β-Tricalcium Phosphate Ceramics via Micro-Computed Tomography (2008)

This paper describes the use of micro-computed tomography for determining in vitro degradation of calcium-phosphate ceramic materials. Samples were immersed in a simulated body fluid and scanned at the initial and final timepoints. Analysis indicates degradation of material density as well as changes in mineral content and mineral density. Findings are confirmed with known methods of materials characterization (SEM, mass analysis, and Archimedes’s density calculations), indicating changes in surface morphology, mass, and pore volume.
A quad-band GSM/GPRS/EDGE SoC in 65nm CMOS (2010)

A quad-band 2.5G SoC integrates all the RF, DSP, ARM, audio and other baseband processing functions into a single 65nm CMOS die. The radio draws a battery current of 49mA in the RX-mode, and 86mA in the GMSK TX-mode. The low-IF receiver achieves a sensitivity of -110dBm at the antenna, corresponding to a noise figure of 2.4dB at the device input. The 8PSK ±400kHz modulation mask is -64.1/62.7dBc for high/low bands, with an RMS EVM of 2.45/1.95%.
Oxide–Oxide Interfaces: Atomistic and Density Functional Study of Cubic‐ZrO 2 (100) ‖ NiO (111) (2001)

The cubic‐ZrO 2 (100) ‖ NiO (111) interface provides an opportunity for comparison between atomic‐scale measurements, atomistic simulations, and theoretical electronic structures. High‐resolution electron microscopy indicates that the oxides share a common oxygen layer and that the small lattice strain is largely taken up by NiO near the interface. Using simple Coulomb plus Buckingham‐type interatomic potentials, we are able to provide a more focused picture, revealing two types of boundary. The lowest energy interface is highly planar, almost ideal in structure; there is a second interface, of higher energy, that shows a rumpled structure with strain taken up by deformation of nickel chains. Depth profiling of atomic site energies permits calculation of interface versus bulk and surface energies, and it shows that the interface effects penetrate only two to three atomic layers. Embedded cluster density functional studies of bulk and interface‐region sites permit the characterization of perturbations of electronic density around the boundaries.
Targeted Maximum Likelihood Estimation for Dynamic Treatment Regimes in Sequentially Randomized Controlled Trials (2012)

Sequential Randomized Controlled Trials (SRCTs) are rapidly becoming essential tools in the search for optimized treatment regimes in ongoing treatment settings. Analyzing data for multiple time-point treatments with a view toward optimal treatment regimes is of interest in many types of afflictions: HIV infection, Attention Deficit Hyperactivity Disorder in children, leukemia, prostate cancer, renal failure, and many others. Methods for analyzing data from SRCTs exist but they are either inefficient or suffer from the drawbacks of estimating equation methodology. We describe an estimation procedure, targeted maximum likelihood estimation (TMLE), which has been fully developed and implemented in point treatment settings, including time to event outcomes, binary outcomes and continuous outcomes. Here we develop and implement TMLE in the SRCT setting. As in the former settings, the TMLE procedure is targeted toward a pre-specified parameter of the distribution of the observed data, and thereby achieves important bias reduction in estimation of that parameter. As with the so-called Augmented Inverse Probability of Censoring Weight (A-IPCW) estimator, TMLE is double-robust and locally efficient. We report simulation results corresponding to two data-generating distributions from a longitudinal data structure.
Variational Learning in Nonlinear Gaussian Belief Networks (2001)

We view perceptual tasks such as vision and speech recognition as inference problems where the goal is to estimate the posterior distribution over latent variables (e.g., depth in stereo vision) given the sensory input. The recent flurry of research in independent component analysis exemplifies the importance of inferring the continuousvalued latent variables of input data. The latent variables found by this method are linearly related to the input, but perception requires nonlinear inferences such as decision-making. Even continuous latent variables such as depth are nonlinearly related to the input. In this paper, we present a unifying framework for stochastic neural networks with nonlinear latent variables. Nonlinear units are obtained by passing the outputs of linear Gaussian units through various nonlinearities. We present a general variational method that maximizes a lower bound on the likelihood of a training set, and give results on two visual feature extraction problems.
Fast and Accurate Closest Point Search on Triangulated Surfaces and its Application to Head Motion Estimation (2003)

The Iterative Closest Point (ICP) algorithm is widely used to register two roughly aligned surfaces. Its most expensive step is the search for the closest point. Many efficient variants have been proposed to speed up this step, however they do not guarantee that the closest point on a triangulated surface is found. Instead they might result in an approximation of the closest point. In this paper we present a method for the closest point search that is fast and exact. The method was implemented and used to evaluate the accuracy of head motion estimation using dense 3D data obtained from a stereo camera system. The results show that the accuracy of the estimated head motion is better than 1 mm for translational movements and better than 1 degree for rotations.
Ion channeling studies of epitaxial Fe and Co silicides on Si (1994)

High quality epitaxial Co and Fe silicides have been grown by molecular beam epitaxy on Si(111) and Si(001) substrates with film thicknesses ranging between 25 and 8400 Å. We used Rutherford backscattering spectrometry channeling techniques to measure the lattice distortion as a function of film thickness. The critical thickness hc corresponding to the film thickness at which strain relieving dislocations begin to appear was determined for CoSi2 on Si(111) and Si(001) as well as for Si on CoSi2(111). For CoSi2 on Si(001), a larger critical thickness was obtained than on Si(111), where hc is ∼45 Å. Epitaxial Si on CoSi2(111) was found to be under a compressive strain up to thicknesses of about 350 Å depending on substrate misorientation. Strain measurements were also performed on epitaxially stabilized Co and Fe monosilicides with the CsCl structure. Channeling measurements on thick epitaxial films of bcc-Fe, Fe3Si, FeSi, and Fe0.5Si were used to determine the crystalline quality. Excellent channeling minimum yields of 4.0% were found for bcc-Fe/Si(111). The results are compared with structural information obtained from x-ray diffraction and Brillouin scattering spectroscopy.
Figure S1 from MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by <i>TP53</i> Mutation in Preclinical Models of Colorectal Cancer (2023)

&lt;p&gt;Figure S1. MEK- and mTOR-inhibition induces cell cycle arrest and apoptosis in CRC cell lines&lt;/p&gt;
Atom Transfer Radical Polymerization of Adenine, Thymine, Cytosine, and Guanine Nucleobase Monomers (2007)

Methacrylate monomers functionalized with thymine, adenine, cytosine, and guanine were prepared by alkylation of the nucleobases with 3-bromopropyl methacrylate. Application of atom transfer radical polymerization in deuterated DMSO allowed controlled polymerization of the adenine-, thymine-, and for the first time, also of the cytosine- and guanine-modified monomers. The guanine and cytosine monomers appeared to form a complex with the copper catalyst, as could be observed with 1H NMR spectroscopy. In the case of guanine, this did not cause any problems for the polymerization process, while in the case of cytosine, a stronger copper binding ligand, PMDETA, needed to be applied to gain control over polymerization.
Cage electron-hydroxyl complex state as electron donor in mayenite (2016)

It is inferred from the chemical shift of muon spin rotation $(\ensuremath{\mu}\mathrm{SR})$ spectra that muons implanted in pristine (fully oxidized) mayenite, ${[{\mathrm{Ca}}_{12}{\mathrm{Al}}_{14}{\mathrm{O}}_{32}]}^{2+}[{\ensuremath{\square}}_{5}{\mathrm{O}}^{2\ensuremath{-}}]$ (C12A7, with $\ensuremath{\square}$ referring to the vacant cage), are bound to ${\mathrm{O}}^{2\ensuremath{-}}$ at the cage center to form ${\mathrm{OMu}}^{\ensuremath{-}}$ (where Mu represents muonium, a muonic analog of the H atom). However, an isolated negatively charged state $({\mathrm{Mu}}^{\ensuremath{-}}$, an analog of ${\mathrm{H}}^{\ensuremath{-}})$ becomes dominant when the compound approaches the state of electride ${[{\mathrm{Ca}}_{12}{\mathrm{Al}}_{14}{\mathrm{O}}_{32}]}^{2+}[{\ensuremath{\square}}_{4}2{\mathrm{e}}^{\ensuremath{-}}]$ as a result of the reduction process. Moreover, the ${\mathrm{OMu}}^{\ensuremath{-}}$ state in the pristine specimen exhibits depolarization of paramagnetic origin at low temperatures (below $\ensuremath{\sim}30$ K), indicating that ${\mathrm{OMu}}^{\ensuremath{-}}$ accompanies a loosely bound electron in the cage that can be thermally activated. This suggests that interstitial muons (and hence H) forming a ``cage electron-hydroxyl'' complex can serve as electron donors in C12A7.
Identification of IVGTT minimal glucose model by nonlinear mixed-effects approaches (2006)

Glucose minimal model parameters are commonly estimated by applying weighted nonlinear least squares to each individual subject's data. Sometimes, parameter precision is not satisfactory, especially in "data poor" conditions. In this work, the use of population analysis through nonlinear-mixed effects models is evaluated and its performance tested against the parameter estimates obtained by the standard individual approach through weighted nonlinear least squares. In particular, we compared the performance of two likelihood approximation methods to estimate nonlinear mixed-effects model parameters, i.e. the first-order conditional estimation (FOCE) and the Laplace approximation (Laplace) methods. The results show that nonlinear mixed-effects population modeling using the FOCE approximation can be successfully used in order to accurately estimate individual minimal model parameters.
[Age-related alteration of tear dynamics in normal volunteers]. (1994)

Age-related alteration of tear dynamics was studied using a newly developed fluorophotometer. The subjects, 55 eyes of 30 normal volunteers, included 32 eyes of 16 younger subjects in their twenties and 23 eyes of 14 older subjects aged 50 years and above. After instillation of 1 microliter of fluorescein solution at a concentration of 50 micrograms/ml into the temporal bulbar conjunctiva, fluorescence intensity was measured with the fluorophotometer every minute for 10 minutes after instillation. Fluorescein concentration was calculated from the intensity, and various parameters of tear dynamics were analyzed. In the younger subjects, the tear volume, initial turnover rate and basal turnover rate were 10.6 +/- 6.0 microliters, 37. 1 +/- 15.6%/min, and 25.8 +/- 15.2%/min, respectively. In the older subjects, these values were 6.5 +/- 2.6 microliters, 26.5 +/- 11.4%/min, and 20.5 +/- 13.5%/min, respectively. The basic tear flow rate, calculated from the basal turnover rate and tear volume, was 2.7 +/- 2.2 microliters/min in the younger and 1.4 +/- 1.0 microliter/min in the older subjects. There was a statistically significant difference in the tear volume, tear turnover rate, and basic tear flow rate between the younger and older subjects.
Gestural text entry on multiple devices (2005)

We present various adaptations of the EdgeWrite unistroke text entry method that work on multiple computer input devices: styluses, touchpads, displacement and isometric joysticks, four keys or buttons, and trackballs. We argue that consistent, flexible, multi-device input is important to both accessibility and to ubiquitous computing. For accessibility, multi-device input means users can switch among devices, distributing strain and fatigue among different muscle groups. For ubiquity, it means users can "learn once, write anywhere," even as new devices emerge. By considering the accessibility and ubiquity of input techniques, we can design for both motor-impaired users and "situationally impaired" able-bodied users who are on-the-go. We discuss the requirements for such input and the challenges of multi-device text entry, such as solving the segmentation problem. This paper accompanies a demonstration of EdgeWrite on multiple devices.
The anatomy of Clickbot.A (2007)

This paper provides a detailed case study of the architecture of the Clickbot.A botnet that attempted a low-noise click fraud attack against syndicated search engines. The botnet of over 100,000 machines was controlled using a HTTP-based botmaster. Google identified all clicks on its ads exhibiting Clickbot.Alike patterns and marked them as invalid. We disclose the results of our investigation of this botnet to educate the security research community and provide information regarding the novelties of the attack. 1.
ChemInform Abstract: SYNTHESIS, PHYSICAL PROPERTIES, AND STRUCTURAL CHARACTERIZATION OF μ‐CARBONATO‐DICHLOROBIS(N,N,N′,N′‐TETRAMETHYL‐1,3‐PROPANEDIAMINE)DICOPPER(II# ), LCUCL(CO3)CLCUL, A DIAMAGNETIC INITIATOR FOR THE OXIDATIVE COUPLING OF PHENOLS BY DIOXYGEN (1979)

Abstract Der Titelkomplex wurde in quantitativer Ausb. durch Reaktion des Liganden mit CuCl, CO 2 und O 2 in wasserfreiem CH 2 Cl 2 erhalten und IR‐, ESR‐ und elektronenspektroskopisch charakterisiert.
Operational versus definitional: a perspective on programming paradigms (1992)

Various paradigms that support high-level programming are discussed independently of supporting languages. The paradigms are grouped according to their approach to problem solving. The operational approach describes step-by-step how to construct a solution. The demonstrational approach is a variation on it that illustrates the solution operationally for specific examples and lets the system generalize these example solutions for other cases. The definitional approach is different. It states properties about the solution to constrain it without describing how to compute it. These three approaches are viewed on a continuum from operational to definitional. A pure language solution to the problem of sorting a list into some linear order is presented for each paradigm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Solubility of Calix[4]resorcinarene in Water from (278.15 to 308.15) K (2009)

The solubility of 2,8,14,20-tetramethyl-4,6,10,12,16,18,22,24-octahidroxyresorci[4]arene, calix[4]resorcinarene, in water has been measured for temperatures ranging from (278.15 to 308.15) K. The experimental data were correlated with the van’t Hoff equation, quadratic equation, and Apelblat equation. The thermodynamic functions of free energy and the enthalpy and entropy of solution were evaluated. The results showed that the main contributor to the standard free energy of solution is the enthalpy.
Elektrisk Design og Styring. Simulation Platform to Model, Optimize and Design Wind Turbines (2004)

This report is a general overview of the results obtained in the project ?Electrical Design and Control. Simulation Platform to Model, Optimize and Design Wind Turbines?. The report is structured in six chapters. First, the background of this project and the main goals as well as the structure of the simulation platform is given. The main topologies for wind turbines, which have been taken into account during the project, are briefly presented. Then, the considered simulation tools namely: HAWC, DIgSILENT, Saber and Matlab/Simulink have been used in this simulation platform are described. The focus here is on the modelling and simulation time scale aspects. The abilities of these tools are complementary and they can together cover all the modelling aspects of the wind turbines e.g. mechanical loads, power quality, switching, control and grid faults. New models and new control algorithms for wind turbine systems have been developed and tested in these tools. All these models are collected in dedicated libraries in Matlab/Simulink as well as in Saber. Some simulation results from the considered tools are presented for MW wind turbines. These simulation results focuses on fixed-speed and variable speed/pitch wind turbines. A good agreement with the real behaviour of these systems is obtained for each simulation tool. These models can easily be extended to model different kinds of wind turbines or large wind farms. The performance of these models is proven and they can be directly implemented in different simulation tools. Then, the general conclusions regarding the achieved results during the project are summarized and some guidelines for future work are given. Finally, the papers and reports published during the project are presented.
Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends (2018)

Telomere-binding proteins constituting the shelterin complex have been studied primarily for telomeric functions. However, mounting evidence shows non-telomeric binding and gene regulation by shelterin factors. This raises a key question-do telomeres impact binding of shelterin proteins at distal non-telomeric sites? Here we show that binding of the telomere-repeat-binding-factor-2 (TRF2) at promoters ~60 Mb from telomeres depends on telomere length in human cells. Promoter TRF2 occupancy was depleted in cells with elongated telomeres resulting in altered TRF2-mediated transcription of distal genes. In addition, histone modifications-activation (H3K4me1 and H3K4me3) as well as silencing marks (H3K27me3)-at distal promoters were telomere length-dependent. These demonstrate that transcription, and the epigenetic state, of telomere-distal promoters can be influenced by telomere length. Molecular links between telomeres and the extra-telomeric genome, emerging from findings here, might have important implications in telomere-related physiology, particularly ageing and cancer.
Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia (2020)

Allogeneic hematopoietic cell transplantation (alloHCT) can cure previously treated high-risk chronic lymphocytic leukemia (CLL) patients if they are suitable for transplant through the graft-versus-leukemia effect. However, since the emergence of targeted therapies, the role of alloHCT for high-risk CLL is less clear. To address this question, we evaluated 108 high-risk CLL patients who underwent alloHCT from 2010 to 2018. Thirty patients from the period of 2013 to 2018 received targeted therapy prior to alloHCT. The median age for the targeted therapy cohort was 60 years (range, 30-71 years), and 20% and 73% had complete and partial remission, respectively: 76% had del(17p), 46.2% had 5 or more cytogenetic abnormalities, and 78.9% were IGHV unmutated. The median number of prior therapies was 4 (range, 1-9). With a median follow-up time of 36 months (range, 10-72 months), the 3-year overall (OS) and progression-free survival (PFS) were 87% and 69%, respectively. The 3-year cumulative incidence of nonrelapse mortality and relapse was 7% and 24%, respectively. For the control cohort of 78 patients who underwent alloHCT from 2010 to 2014 and received only chemoimmunotherapy prior to transplant, the 3-year OS and PFS were 69% and 58%, respectively. Patients treated with targeted therapy prior to alloHCT had a significantly higher number of circulating T and B cells and a lower ratio of CD4 regulatory T cells to CD4 conventional T cells early after transplant. In summary, despite multiple high-risk features, the clinical outcome of CLL patients who receive targeted therapy prior to transplant is excellent and alloHCT should be offered while the disease is under control.
Structure-based drug design of chromone antagonists of the adenosine A2A receptor (2014)

Structure-based drug design identifies potent &amp; selective GPCR antagonists.
Direct observation of uniform optical properties from microphotoluminescence mapping of InGaN quantum wells grown on slightly misoriented GaN substrates (2008)

Abstract We have studied microphotoluminescence mapping of InGaN quantum wells grown on GaN (0001) substrates with misorientation toward [1 $/bar 1$ 00] direction. The fluctuation of peak energy and full width at half maximum in the mapping was large when the misorientation angle was 0.0° or 0.1°, whereas it was small when the misorientation angle was over 0.2°. The average of the full width at half maximum of InGaN peak had the minimum of below60 meV at room temperature when the misorientation angle was around 0.28°. These results indicate that InGaN quantum wells have high crystalline quality when grown on GaN (0001) substrates with misorientation angle between 0.2° and 0.3° toward [1 $/bar 1$ 00] direction. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Characterization of 6-epi-3-Anhydroophiobolin B from Cochliobolus heterostrophus (1999)

The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.
Controversies in Treating Diabetes (2008)

Diabetes Mellitus is an extremely common disorder and the number of patients is increasing every year. Controversies in Treating Diabetes: Clinical and Research Aspects addresses diabetes controversie
Tough Times for Medicinal Chemists: Are We to Blame? (2013)

In the United States, medicinal chemists continue to face job insecurity and high rates of unemployment. The situation is unlikely to improve in the near future. Is there a light at the end of the tunnel? Is there anything we can do to revitalize our community? The answer may be right in front of us.