gebhart/patrepeval huggingface dataset:
Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ (2016)

Coronary reactive hyperemia (CRH) is a physiological response to ischemic insult that prevents the potential harm associated with an interruption of blood supply. The relationship between the pharmacologic inhibition of soluble epoxide hydrolase (sEH) and CRH response to a brief ischemia is not known. sEH is involved in the main catabolic pathway of epoxyeicosatrienoic acids (EETs), which are converted into dihydroxyeicosatrienoic acids (DHETs). EETs protect against ischemia/reperfusion injury and have numerous beneficial physiological effects. We hypothesized that inhibition of sEH by t-AUCB enhances CRH in isolated mouse hearts through changing the oxylipin profiles, including an increase in EETs/DHETs ratio. Compared to controls, t-AUCB-treated mice had increased CRH, including repayment volume (RV), repayment duration, and repayment/debt ratio (p < 0.05). Treatment with t-AUCB significantly changed oxylipin profiles, including an increase in EET/DHET ratio, increase in EpOME/DiHOME ratio, increase in the levels of HODEs, decrease in the levels of mid-chain HETEs, and decrease in prostanoids (p < 0.05). Treatment with MS-PPOH (CYP epoxygenase inhibitor) reduced CRH, including RV (p < 0.05). Involvement of PPARγ in the modulation of CRH was demonstrated using a PPARγ-antagonist (T0070907) and a PPARγ-agonist (rosiglitazone). T0070907 reduced CRH (p < 0.05), whereas rosiglitazone enhanced CRH (p < 0.05) in isolated mouse hearts compared to the non-treated. These data demonstrate that sEH inhibition enhances, whereas CYP epoxygenases-inhibition attenuates CRH, PPARγ mediate CRH downstream of the CYP epoxygenases-EET pathway, and the changes in oxylipin profiles associated with sEH-inhibition collectively contributed to the enhanced CRH.
Phenolic acid amides of phenolic benzylamines against UVA‐induced oxidative stress in skin¶ (2001)

UVA-radiation is suspected to be a main cause for extrinsic skin ageing in humans. Recent studies showed that topically administered molecular antioxidants are able to protect skin against UVA-generated oxidative stress. Therefore, new phenolic acid amides of phenolic benzylamines were synthesized as potential antioxidants by reaction of (if necessary protected) N-succinimidylesters of ferulic acid, sinapic acid, caffeic acid, 3-(4-hydroxy-3-methoxyphenyl)propanoic acid, 3-(3,4-dihydroxyphenyl)propanoic acid, 2-(4-hydroxy-3-methoxyphenyl)acetic acid and 2-(3,4-dihydroxyphenyl) acetic acid with different phenolic benzylamines in moderate to good yields. The radical scavenging activities of the compounds were determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and by a superoxide radical anion trapping assay. Antioxidant activities in bulk lipids were tested by accelerated peroxidation with or without test compounds performed in the Rancimat apparatus. Stripped soybean oil and the skin sebum component squalene were used as lipids. The synthesized compounds were found to be efficient radical scavengers and antioxidants, especially the hydroxyphenylacetic amides and the hydroxydihydrocinnamic acid amides of polyhydroxybenzylamines, which are superior to the standards alpha-tocopherol and l-ascorbic acid. A topically applied 0.1% 1,3-butyleneglycol solution of N-(3,4-dihydroxybenzyl)-2-(4-hydroxy-3-methoxyphenyl)acetic acid amide 19 inhibits the UVA-induced sebum peroxidation in human skin significantly, by 39%.
Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study (2014)

Our findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes. For men, taking Prx4 into consideration can improve type 2 diabetes prediction over a validated diabetes risk score; in contrast, there is no improvement in risk prediction for women.
Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Prospective Cohort Study (2019)

Active articular RA was associated with an increased risk of developing RA-ILD. These results suggest that decreasing systemic inflammation may alter the natural history of RA-ILD development.
One- vs Two-Burr-Hole Technique for Combined Endoscopic Third Ventriculostomy and Pineal Region Biopsy: Volumetric Analysis of Brain at Risk (2020)

Using 1 burr hole for both the ETV and tumor biopsy is less likely to traumatize the brain parenchyma than using 2 burr holes. However, 1 burr hole predisposes the fornix to stretch injury. We recommend tailoring the entry to each patient according to their anatomy rather than using a 1-size-fits-all approach.
Measurement of the W gamma and Z gamma inclusive cross sections in pp collisions at root s=7 TeV and limits on anomalous triple gauge boson couplings (2014)

Made available in DSpace on 2014-07-30T13:40:37Z (GMT). No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-10T18:32:14Z : No. of bitstreams: 1 000335829100002.pdf: 1251071 bytes, checksum: 39d43c1865f8a781f6190f0608652586 (MD5)
Three-dimensional Nanoantenna Inverse-design (2019)

Realizing a diverse set of high-performance nanoantennas for phase-gradient applications can be extremely challenging without the aid of formal inverse-design techniques. To this end, an inverse-design procedure based on the Multi-Objective Lazy Ant Colony Optimization (MOLACO) algorithm is proposed for the synthesis of three-dimensional nanoantenna geometries that achieve high transmission performance and a wide range of phase options. A unit cell geometry suitable for a Membrane Projection Lithography fabrication technique is presented and explored by MOLACO in order to discover a set of highly transmissive nanoantennas that achieve a full 2π phase range. Finally, future research directions and applications are briefly discussed.
Mechanical and thermal properties of nanomaterials at sub-50nm dimensions characterized using coherent EUV beams (2015)

Coherent extreme ultraviolet beams from tabletop high harmonic generation offer several revolutionary capabilities for observing nanoscale systems on their intrinsic length and time scales. By launching and monitoring hypersonic acoustic waves in such systems, we characterize the mechanical properties of sub-10nm layers and find that the material densities remain close to their bulk values while their elastic properties are significantly modified. Moreover, within the same measurement, by following the heat dissipation dynamics from 30-750nm-wide nanowires, we uncover a new thermal transport regime in which closely-spaced nanoscale heat sources can surprisingly cool more efficiently than widelyspaced heat sources of the same size.
Plasma Copeptin, A Unifying Factor behind the Metabolic Syndrome (2011)

Our data suggest that increased activity of the AVP system is a unifying factor in the MetS and point to a new pharmacologically modifiable system of potential importance in the treatment of MetS and prevention of cardiovascular disease.
Improving the analysis of near-infrared spectroscopy data with multivariate classification of hemodynamic patterns: a theoretical formulation and validation (2018)

The results obtained suggest that the outcome of GLM analysis is highly vulnerable to violations of theoretical assumptions, and that therefore a data-driven approach such as that provided by the proposed LDA-based method is to be favored.
Decoupling and Reprogramming the Wiggling Motion of Midge Larvae Using a Soft Robotic Platform (2022)

The efficient motility of invertebrates helps them survive under evolutionary pressures. Reconstructing the locomotion of invertebrates and decoupling the influence of individual basic motion are crucial for understanding their underlying mechanisms, which, however, generally remain a challenge due to the complexity of locomotion gaits. Herein, a magnetic soft robot to reproduce midge larva's key natural swimming gaits is developed, and the coupling effect between body curling and rotation on motility is investigated. Through the authors' systematically decoupling studies using programmed magnetic field inputs, the soft robot (named LarvaBot) experiences various coupled gaits, including biomimetic side-to-side flexures, and unveils that the optimal rotation amplitude and the synchronization of curling and rotation greatly enhance its motility. The LarvaBot achieves fast locomotion and upstream capability at the moderate Reynolds number regime. The soft robotics-based platform provides new insight to decouple complex biological locomotion, and design programmed swimming gaits for the fast locomotion of soft-bodied swimmers.
Enhanced Business Intelligence using EROCS (2008)

The EROCS technology automatically links unstructured data with relevant structured data from an external relational database. We demonstrate how EROCS can be used for enhancing business intelligence by allowing OLAP tools to analyze structured and unstructured data in a consolidated manner. Our demonstration showcases the use of EROCS in exploiting latent information in customer emails, which helps in building a complete view of the customer. This results in new insights about the business which are not possible with the existing state of the art.
Influenza D Virus Infection in Feral Swine Populations, United States (2018)

Influenza D virus (IDV) has been identified in domestic cattle, swine, camelid, and small ruminant populations across North America, Europe, Asia, South America, and Africa. Our study investigated seroprevalence and transmissibility of IDV in feral swine. During 2012-2013, we evaluated feral swine populations in 4 US states; of 256 swine tested, 57 (19.1%) were IDV seropositive. Among 96 archived influenza A virus-seropositive feral swine samples collected from 16 US states during 2010-2013, 41 (42.7%) were IDV seropositive. Infection studies demonstrated that IDV-inoculated feral swine shed virus 3-5 days postinoculation and seroconverted at 21 days postinoculation; 50% of in-contact naive feral swine shed virus, seroconverted, or both. Immunohistochemical staining showed viral antigen within epithelial cells of the respiratory tract, including trachea, soft palate, and lungs. Our findings suggest that feral swine might serve an important role in the ecology of IDV.
Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator (2016)

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel in the apical surface of epithelial cells in the airway and gastrointestinal tract, and mutation of CFTR is the underlying cause of cystic fibrosis. However, the precise molecular details of the structure and function of CFTR in native and disease states remains elusive and cystic fibrosis researchers are hindered by a lack of high specificity, high affinity binding reagents for use in structural and biological studies. Here, we describe a panel of synthetic antigen-binding fragments (Fabs) isolated from a phage-displayed library that are specific for intracellular domains of CFTR that include the nucleotide-binding domains (NBD1 and NBD2), the R-region, and the regulatory insertion loop of NBD1. Binding assays performed under conditions that promote the native fold of the protein demonstrated that all Fabs recognized full-length CFTR. However, only the NBD1-specific Fab recognized denatured CFTR by western blot, suggesting a conformational epitope requirement for the other Fabs. Surface plasmon resonance experiments showed that the R-region Fab binds with high affinity to both the phosphorylated and unphosphorylated R-region. In addition, NMR analysis of bound versus unbound R-region revealed a distinct conformational effect upon Fab binding. We further defined residues involved with antibody recognition using an overlapping peptide array. In summary, we describe methodology complementary to previous hybridoma-based efforts to develop antibody reagents to CFTR, and introduce a synthetic antibody panel to aid structural and biological studies.
ChemInform Abstract: Practical EPC Synthesis of 1,2‐ and 1,3‐Amino Alcohols. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structured Interview Guide and Template for Specification of Woody Biomass Fuel and Feedstocks (2011)

Lack of full technical specification for biomass fuels and feedstocks is a major source of confusion, uncertainty, and conflict throughout the supply chain. With support from US Department of Agriculture and US Department of Energy, we have interviewed scores of industry participants and reviewed both the scientific and commercial literature to develop a template for specification of biomass materials. The resulting structured interview guide and template for documenting specifications can be situationally modified for various feedstocks, conversion processes and end products. The template emphasizes physical properties, biogeometric dimensional properties, and anatomical content.
SILANE-TERMINATED LIQUID POLY(BUTADIENES) IN TREAD FORMULATIONS: A MECHANISTIC STUDY (2020)

ABSTRACT Liquid poly(butadienes) are materials that exhibit flow properties as their molecular weights are at or below that for significant chain entanglement. When applied to tire compound formulation in additive amounts, these low-molecular-weight oligomers are compatible with the elastomeric phase and can influence viscoelastic behavior. The present article will catalogue the history of the use of liquid poly(butadiene) materials in tire compounding, linking their varied application to the evolution of structure–property relationships as a function of microstructure changes. The result of this evolution is the commercialization of functionalized liquid polybutadienes, specifically silane-terminated grades designed for silica-filled systems. It has been found that these materials are not replacements for the typical silane coupling agents ubiquitously used in silica formulating but are rather synergistic with the established technology. The application of silane-terminated liquid poly(butadienes) can both improve traction indicators and limit the negative hysteresis effect commonly associated with the use of liquid poly(butadiene) resins. The mechanism behind the specific changes in viscoelastic and mechanical properties attributed to the addition of silane-terminated liquid poly(butadienes) is explored. It is found that the terminal silane function of the liquid poly(butadienes) may both interact with the silane coupling agent–modified surface of the dispersed silica particles and be available to condense with each other, forming a higher-molecular-weight structure that may effectively increase the apparent crosslink density and therefore bound rubber as an interpenetrating network that extends well into the elastomer phase.
Long-term Water Distribution Design (2013)

Water distribution piping has a useful life on the order of a century while pipe-sizing decisions are usually based on a planning horizon on the order of 20 years. Because of the substantial economy of scale in pipe sizing and the long useful life, there may be benefits to installing piping with some excess capacity in the short term depending on expected long-term growth. The analysis presented in this paper shows the value in considering long-term growth in demand even if the planning horizon for the study is much shorter. While the only decision that needs to be made in the current year is the size of the initial pipe, it is important that the pipe fits into a long-term plan for the distribution system but the exact diameter doesn't make much difference.
VEGF-mediated cross-talk within the neonatal murine thymus (2008)

Although the mechanisms of cross-talk that regulate the hematopoietic and epithelial compartments of the thymus are well established, the interactions of these compartments with the thymic endothelium have been largely ignored. Current understanding of the thymic vasculature is based on studies of adult thymus. We show that the neonatal period represents a unique phase of thymic growth and differentiation, marked by endothelium that is organized as primitive, dense networks of capillaries dependent on vascular endothelial growth factor (VEGF). VEGF dependence in neonates is mediated by significantly higher levels of both VEGF production and endothelial VEGF receptor 2 (VEGF-R2) expression than in the adult thymus. VEGF is expressed locally in the neonatal thymus by immature, CD4(-)CD8(-) "double negative" (DN) thymocytes and thymic epithelium. Relative to adult thymus, the neonatal thymus has greater thymocyte proliferation, and a predominance of immature thymocytes and cortical thymic epithelial cells (cTECs). Inhibition of VEGF signaling during the neonatal period results in rapid loss of the dense capillaries in the thymus and a marked reduction in the number of thymocytes. These data demonstrate that, during the early postnatal period, VEGF mediates cross-talk between the thymocyte and endothelial compartments of the thymus.
Self-Assembled Hexa- peri -hexabenzocoronene Graphitic Nanotube (2004)

An amphiphilic hexa-peri-hexabenzocoronene self-assembles to form a pi-electronic, discrete nanotubular object. The object is characterized by an aspect ratio greater than 1000 and has a uniform, 14-nanometer-wide, open-ended hollow space, which is an order of magnitude larger than those of carbon nanotubes. The wall is 3 nanometers thick and consists of helical arrays of the pi-stacked graphene molecule, whose exterior and interior surfaces are covered by hydrophilic triethylene glycol chains. The graphitic nanotube is redox active, and a single piece of the nanotube across 180-nanometer-gap electrodes shows, upon oxidation, an electrical resistance of 2.5 megohms at 285 kelvin [corrected]. This family of molecularly engineered graphite with a one-dimensional tubular shape and a chemically accessible surface constitutes an important step toward molecular electronics.
Quantum Systems on Non-$k$-Hyperfinite Complexes: a generalization of classical statistical mechanics on expander graphs (2014)

We construct families of cell complexes that generalize expander graphs. These families are called non-$k$-hyperfinite, generalizing the idea of a non-hyperfinite (NH) family of graphs. Roughly speaking, such a complex has the property that one cannot remove a small fraction of points and be left with an object that looks $k-1$-dimensional at large scales. We then consider certain quantum systems on these complexes. A future goal is to construct a family of Hamiltonians such that every low energy state has topological order as part of an attempt to prove the quantum PCP conjecture. This goal is approached by constructing a toric code Hamiltonian with the property that every low energy state without vertex defects has topological order, a property that would not hold for any local system in any lattice $Z^d$ or indeed on any $1$-hyperfinite complex. Further, such NH complexes find application in quantum coding theory. The hypergraph product codes\cite{hpc} of Tillich and Z\'{e}mor are generalized using NH complexes.
Introduction: Nonlinear Optics (NLO) 2017 feature issue (2018)

The editors introduce the feature issue on "Nonlinear Optics 2017," based on the topics presented at the NLO 2017 conference, which was held in Waikoloa, Hawaii, USA from July 17-21, 2017. This feature issue is jointly published by Optics Express and Optical Materials Express.
Induction of p53 and p21WAF1CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells (1996)

In this study, human and rat cancer cells were used to investigate the expression of p53 and p21/WAF1/CIP1 and their association with apoptosis after exposure to nitric oxide (NO). It was found that NO induced nuclear accumulation of p53 protein in a dose- and time-dependent manner. The level of p53 protein was elevated by about fivefold compared with that of mock-treated cells 48 h after exposure to 300 ppm NO. The induction of p53 by NO was found by pulse-chase analysis to be mainly regulated by post-translational modification. The correlation between p53 status and apoptosis induced by NO in human cancer cells was also investigated in this study. We found that apoptosis was easily induced in cells containing wild-type p53 (COLO 205 and Hep G2) after exposure to NO. The p21/WAF1/CIP1 protein was induced by NO in cells containing wild-type p53 (Hep G2) but not in cells without p53 (Hep 3B) or with mutated p53 (HT-29). Our results indicate that wild-type p53 and p21/WAF1/CIP1 expression was elevated in human cancer cells by exposure to NO and suggest that this may eventually promote apoptosis. © 1996 Wiley-Liss, Inc.
Electromechanical Tuning of Self-Sensing Piezoelectric Transducers (1998)

The application of a self-sensing piezoelectric transducer included in a bridge readout network is here investigated taking into account the electromechanical interaction. The parametric uncertainties and the piezoelectric device losses as well as the tolerances of the electric components make the balancing of the bridge difficult to achieve in practice. A loss and uncertainties compensation, based on a real-time software implementation of the bridge reference arm is here presented and validated. The standard electrical and the proposed electromechanical balancing are both theoretically and experimentally compared in the case of a simple beam. The bridge output signal that is proportional to the strain rate is then fed back by means of a sharp phase second order low pass filter which is aimed at increasing the damping of the first bending mode of the beam.
Structure elucidation of omphalotin, a cyclic dodecapetide with potent nematicidal activity isolated fromOmphalotus olearius (1998)

The structure and absolute configuration of omphalotin, a cyclic dodecapeptide isolated from the basidiomycete fungus Omphalotus olearius and possessing potent and selective activity against the plant pathogenic nematode Meloidogyne incognita, was determined by a combination of spectroscopic and chemical techniques. © 1998 Society of Chemical Industry
G-Protein-Coupled Receptor Signaling in Cilia (2017)

G-protein-coupled receptors (GPCRs) are the largest and most versatile family of signaling receptors in humans. They respond to diverse external signals, such as photons, proteins, peptides, chemicals, hormones, lipids, and sugars, and mediate a myriad of functions in the human body. Signaling through GPCRs can be optimized by enriching receptors and downstream effectors in discrete cellular domains. Many GPCRs have been found to be selectively targeted to cilia on numerous mammalian cell types. Moreover, investigations into the pathophysiology of human ciliopathies have implicated GPCR ciliary signaling in a number of developmental and cellular pathways. Thus, cilia are now appreciated as an increasingly important nexus for GPCR signaling. Yet, we are just beginning to understand the precise signaling pathways mediated by most ciliary GPCRs and how they impact cellular function and mammalian physiology.
Maggots and wound healing: an investigation of the effects of secretions fromLucilia sericatalarvae upon interactions between human dermal fibroblasts and extracellular matrix components (2003)

L. sericata larval secretions modify fibroblast adhesion and spreading across ECM protein surfaces, while keeping cells viable. Proteolytic activity of the ES played a significant role. If transferred to the wound situation, such alteration of fibroblast-ECM interactions may enhance new tissue formation.