gebhart/patrepeval huggingface dataset:
A 5G V2X testbed for cooperative automated driving (2016)

Ensuring low-latency and highly reliable communication between vehicles is one of the goals of 5G. We present a 5G Vehicle-to-everything (V2X) wireless testbed based on flexible and re-configurable software defined radio that is designed for cooperative automated driving. The use-cases and communication requirements for cooperative automated driving are discussed to motivate the system design and technical enablers that can achieve the most stringent link-level communication requirements of cooperative autonomous driving. The key building blocks include a re-configurable RF front-end, optimized base-band processing on standard Intel CPUs and a custom-built high-power external RF subsystem. The technical enablers include a new OFDM-like waveform based on Pulse-shaping, a flexible and self-contained frame-structure design, GNSS-aided hybrid synchronization and low-latency scheduled multiple-access. We finally present some experimental results from lab measurements.
Phase 3 LITESPARK-022: Pembrolizumab (pembro) plus hypoxia-inducible factor 2α (HIF-2α) inhibitor belzutifan as adjuvant treatment for clear cell renal cell carcinoma (ccRCC). (2023)

TPS748 Background: Treatment with the PD-1 inhibitor pembro produced significant improvement in disease-free survival after surgery for patients (pts) with ccRCC in the phase 3 KEYNOTE-564 trial. Based on these results, pembro was approved by the US Food and Drug Administration and the European Medicines Agency for adjuvant treatment of pts with RCC at increased risk of recurrence following nephrectomy or following nephrectomy and resection of metastatic lesions. Despite advances in the treatment landscape for RCC, more effective adjuvant treatment strategies are needed for pts at risk of recurrence after surgery. HIF-2α is an established oncogenic driver in ccRCC, and promising antitumor activity in advanced ccRCC and von Hippel-Lindau disease–associated RCC has been demonstrated with the HIF-2α inhibitor belzutifan. The multicenter, double-blind, randomized, phase 3 LITESPARK-022 study (NCT05239728) will evaluate the efficacy and safety of pembro plus belzutifan compared with placebo plus pembro as adjuvant treatment following nephrectomy in pts with ccRCC. Methods: Key eligibility criteria include adults with histologically or cytologically confirmed intermediate-high risk, high risk, or M1 with no evidence of disease (NED) RCC with a clear cell component; pts with no prior systemic therapy, nephrectomy, and/or metastasectomy ≤12 weeks before randomization; and pts who are tumor free per computed tomography/magnetic resonance imaging. Approximately 1600 pts will be randomly assigned to receive belzutifan 120 mg orally once daily plus pembro 400 mg intravenously (IV) every 6 weeks (Q6W) for ≤9 administrations (~54 weeks) or oral placebo plus pembro 400 mg IV Q6W for ≤9 administrations (~54 weeks) or until verified disease recurrence by blinded independent central review, start of new anticancer treatment, unacceptable toxicity, or decision to withdraw. Stratification factors are tumor grade (1 or 2 vs 3 or 4) and risk type (intermediate-high risk versus high risk versus M1 NED). Pts will be radiologically evaluated Q12W from randomization through year 2, Q16W in years 3 to 5, and Q24W in years 6 and beyond. Adverse events will be monitored throughout the study and for 30 days following cessation of study treatment (90 days for serious adverse events). The primary end point is disease-free survival. Secondary end points include overall survival, safety, disease recurrence–specific survival, and patient-reported outcomes. Recruitment is underway in Asia, Australia, Europe, North America, and South America. © 2022 American Society of Clinical Oncology, Inc. Reused with permission. This abstract was accepted and previously presented at the 2022 ASCO Annual Meeting. All rights reserved. Clinical trial information: NCT05239728 .
A direct method for the diagnosis of human hepatic type 1b and type 1c glycogen-storage disease (1989)

1. Type 1b and type 1c glycogen-storage disease are caused respectively by deficiencies of the glucose-6-phosphate translocase and the phosphate/pyrophosphate translocase of the human hepatic microsomal glucose-6-phosphatase system. 2. Current methods of unequivocally diagnosing type 1b and type 1c glycogen storage disease are indirect and complex. 3. We have therefore developed a simple, rapid and direct microfiltration assay for the glucose-6-phosphate translocase and the phosphate/pyrophosphate translocase. 4. We have demonstrated that the microfiltration assay can be used to directly diagnose type 1b and 1c glycogen-storage disease in microsomes isolated from hepatic needle-biopsy samples.
Learning-Based Floor-Type Identification in the ZUPT-Aided Pedestrian Inertial Navigation (2021)

We present a method to identify the floor types in the pedestrian inertial navigation with the goal of adaptive estimation of navigation states under various navigation scenarios. The floor-type detection algorithm includes three major steps. First, the inertial measurement unit readouts are divided with each partition corresponding to a full human gait cycle. Second, principal component analysis is conducted on each partition to reduce dimensionality of the data. Third, the data are fed into an artificial neural network (ANN) for the floor-type identification. In this study, we identified five different floor types: walking on hard floor, walking on grass, walking on sand, walking upstairs, and walking downstairs, with an accuracy of over 99%. To verify the effects of the floor-type detection, the classification result was used to select proper parameters in the zero-velocity-update-aided pedestrian inertial navigation in the multiple model approach. Advantages of the identification approach were experimentally verified, and resulted in a reduced navigation error in the field test.
High-accuracy Gain-isolated Volterra Nonlinear Behavior Model for Wideband Driver in Optical Coherent Transmitter (2016)

Gain-isolated Volterra nonlinear model is proposed for the electrical driver. Experiment demonstrates 0.5dB Q error when input signal is PAM 2/4/8 corresponding to 4/16/64QAM modulation. Furthermore, nonlinear impact of driver and Mach-Zehnder modulator are simulated.
Hydrogen in smoke detected by the Pd-gate field-effect transistor (1976)

A recently developed hydrogen-sensitive Pd-gate MOS-transistor was used to detect small amounts of hydrogen in smoke. It is shown that the device can be used to detect a fire before it has really started and therefore has a potential application as a fire alarm.
Electrical characterization of metal-insulator-semiconductor diodes fabricated from laser-ablated YBa2Cu3O7−δ /yttria-stabilized zirconia films on Si substrates (1991)

The purpose of this investigation is to study the electrical properties of the YBCO/YSZ/Si metal-insulator-semiconductor structure and the yttria-stabilized zirconia (YSZ)/Si interface. The YBCO and YSZ layers were epitaxially grown in situ on Si by pulsed laser deposition. Current-voltage measurements of devices fabricated on p-type Si(100) showed a small leakage current density at 292 K, which decreased further at 80 K. Comparison of capacitance-voltage measurements at 292 K for frequencies between 10 and 400 kHz showed a large variation of capacitance in the accumulation region demonstrating the presence of mobile ions in the YSZ layer. This variation is less pronounced at 80 K. A negative shift of about 5 V in threshold voltage from 292 to 80 K has been attributed to redistribution of charges in the YSZ buffer layer.
Figure s1 from Characterization of the Anti–PD-1 Antibody REGN2810 and Its Antitumor Activity in Human <i>PD-1</i> Knock-In Mice (2023)

&lt;p&gt;REGN2810 binds to PD-1 on engineered Jurkat cells and on activated human and cynomolgus monkey T cells.&lt;/p&gt;
Microsoft index turning wizard for SQL Server 7.0 (1998)

No abstract available.
Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems (2013)

We developed a microfluidic flow-control system capable of dynamically generating various flow patterns on demand. The flow-control system is based on novel magnetoactive sponges embedded in microfluidic flow channels. Applying a non-uniform magnetic field compresses the magnetoactive sponge, significantly reducing porosity and hydraulic conductivity. Tuning the applied magnetic field can dynamically vary the flow rate in the microfluidic channel. Pulsatile and physiological flow patterns with frequency between 1 and 3 Hz, flow rates between 0.5 and 10 μL min(-1) and duration over 3 weeks have been achieved. Smooth muscle cells in engineered blood vessels perfused for 7 days aligned perpendicular to the flow direction under pulsatile but not steady flow, similar to the in vivo orientation. Owing to its various advantages over traditional flow-control methods, the new system potentially has important applications in microfluidic-based microphysiological systems to simulate the physiological nature of blood flow.
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. (1994)

Interferon (IFN) consensus sequence binding protein (ICSBP) is a transcription factor expressed mostly in the cells of the immune system. ICSBP belongs to the IFN regulatory factor (IRF) family, which also includes IRF-1, IRF-2, and the IFN-alpha-stimulated gene factor 3 gamma (ISGF3 gamma). We show here that ICSBP forms a complex with IRF-1 or IRF-2 both in vivo and in vitro and, in the presence or absence of the target DNA, with the IFN-stimulated response element (ISRE). Further, electrophoretic mobility shift assays show that this interaction greatly enhances the otherwise very low binding affinity of ICSBP to the ISRE. We show, on the other hand, that ICSBP inhibits binding of the IFN-alpha-stimulated gene factor 3 gamma to the ISRE. Through these interactions ICSBP is likely to exert complex modulatory functions in the regulation of IFN-stimulated genes.
Toward Artificial Mitochondrion: Mimicking Oxidative Phosphorylation in Polymer and Hybrid Membranes (2017)

For energy supply to biomimetic constructs, a complex chemical energy-driven ATP-generating artificial system was built. The system was assembled with bottom-up detergent-mediated reconstitution of an ATP synthase and a terminal oxidase into two types of novel nanocontainers, built from either graft copolymer membranes or from hybrid graft copolymer/lipid membranes. The versatility and biocompatibility of the proposed nanocontainers was demonstrated through convenient system assembly and through high retained activity of both membrane-embedded enzymes. In the future, the nanocontainers might be used as a platform for the functional reconstitution of other complex membrane proteins and could considerably expedite the design of nanoreactors, biosensors, and artificial organelles.
Electron spin resonance detected by a superconducting qubit (2012)

A new method for detecting the magnetic resonance of electronic spins at low temperature is demonstrated. It consists in measuring the signal emitted by the spins with a superconducting qubit that acts as a single-microwave-photon detector, resulting in an enhanced sensitivity. We implement such an electron-spin resonance spectrometer using a hybrid quantum circuit in which a transmon qubit is coupled to a spin ensemble consisting of nitrogen-vacancy (NV) centers in diamond. With this setup we measure the NV center absorption spectrum at 30 mK at an excitation level of $\ensuremath{\sim}15\phantom{\rule{0.16em}{0ex}}{\ensuremath{\mu}}_{B}$ out of an ensemble of ${10}^{11}$ spins.
Nanoparticles in the clinic: An update post COVID‐19 vaccines (2021)

Nanoparticles are used in the clinic to treat cancer, resolve mineral deficiencies, image tissues, and facilitate vaccination. As a modular technology, nanoparticles combine diagnostic agents or therapeutics (e.g., elements, small molecules, biologics), synthetic materials (e.g., polymers), and biological molecules (e.g., antibodies, peptides, lipids). Leveraging these parameters, nanoparticles can be designed and tuned to navigate biological microenvironments, negotiate biological barriers, and deliver therapeutics or diagnostic agents to specific cells and tissues in the body. Recently, with the Emergency Use Authorization of the COVID-19 lipid nanoparticle vaccines, the advantages and potential of nanoparticles as a delivery vehicle have been displayed at the forefront of biotechnology. Here, we provide a 5-year status update on our original "Nanoparticles in the Clinic" review (also a 2-year update on our second "Nanoparticles in the Clinic" review) by discussing recent nanoparticle delivery system approvals, highlighting new clinical trials, and providing an update on the previously highlighted clinical trials.
Vortex (1996)

Previously, techniques such as class hierarchy analysis and profile-guided receiver class prediction have been demonstrated to greatly improve the performance of applications written in pure object-oriented languages, but the degree to which these results are transferable to applications written in hybrid languages has been unclear. In part to answer this question, we have developed the Vortex compiler infrastructure, a language-independent optimizing compiler for object-oriented languages, with front-ends for Cecil, C++, Java, and Modula-3. In this paper, we describe the Vortex compiler's intermediate language, internal structure, and optimization suite, and then we report the results of experiments assessing the effectiveness of different combinations of optimizations on sizable applications across these four languages. We characterize the benchmark programs in terms of a collection of static and dynamic metrics, intended to quantify aspects of the "object-orientedness" of a program.
Dialkyl and diaryl carbonates by carbonate interchange reaction with dimethyl carbonate (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDialkyl and diaryl carbonates by carbonate interchange reaction with dimethyl carbonateAbbas Alli G. Shaikh and Swaminathan SivaramCite this: Ind. Eng. Chem. Res. 1992, 31, 4, 1167–1170Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ie00004a028https://doi.org/10.1021/ie00004a028research-articleACS PublicationsRequest reuse permissionsArticle Views1251Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neutrophil recruitment limited by high affinity bent β2 integrin binding ligand in cis (2016)

Abstract Neutrophils are essential in innate immunity and inflammation. Many neutrophil functions are β2 integrin-dependent. Integrins can extend (E+) and acquire a high affinity conformation with an “open” headpiece (H+). The canonical switchblade model of integrin activation proposes that the E+ conformation precedes H+, and the two are believed to be structurally linked. Here, by using high-resolution quantitative dynamic foot printing (qDF) microscopy combined with a homogenous conformation-reporter binding assay in a microfluidic device, we show that a substantial fraction of β2 integrins on human neutrophils acquires an unexpected E−H+ conformation. Beside the observations consistent with the canonical switchblade model, we discovered a new alternative model that some β2 integrins transition from E−H− to E−H+ to E+H+ during activation. Using flow cytometry based Förster resonance energy transfer (FRET) assay, we find out that E−H+ β2 integrin binds its ligand intercellular adhesion molecule 1 (ICAM-1) in cis. And this cis binding significantly inhibits the conformational transitioning of β2 integrin from E−H+ to E+H+ and the neutrophil adhesion under flow, which indicates a novel endogenous anti-inflammatory mechanism inhibits neutrophil accumulation and inflammation.
Management of Severe Bone Loss in Revision Total Knee Arthroplasty (2009)

Severe bone loss may be encountered in a multitude of scenarios during revision total knee arthroplasty, such as osteolysis and component subsidence, and is a challenge for the joint replacement surgeon. The appropriate reconstructive techniques are dictated by the quantity and location of the tibia
Working memory performance in bipolar disorder (2012)

Sellgren, Ca; Engberg, Gb; Erhardt, Sb; Lichtenstein, Pa; Landèn, Ma,c Author Information
Hydrophobic Determinants of α-Defensin Bactericidal Activity (2014)

Mammalian α-defensins are approximately 4- to 5-kDa broad-spectrum antimicrobial peptides and abundant granule constituents of neutrophils and small intestinal Paneth cells. The bactericidal activities of amphipathic α-defensins depend in part on electropositive charge and on hydrophobic amino acids that enable membrane disruption by interactions with phospholipid acyl chains. Alignment of α-defensin primary structures identified conserved hydrophobic residues in the loop formed by the Cys(III)-Cys(V) disulfide bond, and we have studied their role by testing the effects of mutagenesis on bactericidal activities. Mouse α-defensin 4 (Crp-4) and rhesus myeloid α-defensin 4 (RMAD-4) were selected for these studies, because they are highly bactericidal in vitro and have the same overall electropositive charge. Elimination of hydrophobicity by site-directed mutagenesis at those positions in Crp-4 attenuated bactericidal activity markedly. In contrast to native Crp-4, the (I23/F25/L26/G)-Crp-4 variant lacked bactericidal activity against Salmonella enterica serovar Typhimurium and did not permeabilize Escherichia coli ML35 cells as a result of removing aliphatic side chains by Gly substitutions. Ala replacements in (I23/F25/L26/A)-Crp-4 restored activity, evidence that hydrophobicity contributed by Ala methyl R-groups was sufficient for activity. In macaques, neutrophil α-defensin RMAD-6 is identical to RMAD-4, except for a F28S difference, and (F28S)-RMAD-4 mutagenesis attenuated RMAD-4 bactericidal activity and E. coli permeabilization. Interestingly, (R31/32D)-Crp-4 lacks activity in these assays despite the presence of the Ile23, Phe25, and Leu26 hydrophobic patch. We infer that electrostatic interactions between cationic α-defensin residues and negative charge on bacteria precede interactions between critical hydrophobic residue positions that mediate membrane disruption and bacterial cell killing.
A Novel Common Cavity Approach for Coherent Beam Combining with Reducing Path-Length Sensitivity (2008)

We investigate a new beam-combining architecture with reduced sensitivity to path-length variations. Additional feedback allows the cavity to oscillate in several supermodes. By selecting the proper supermode, perfect coherence and higher output radiance is achieved.
Glucocorticoids increase skeletal muscle NF‐κB inducing kinase (NIK): links to muscle atrophy (2016)

Glucocorticoids (GC) are a frontline therapy for numerous acute and chronic diseases because of their demonstrated efficacy at reducing systemic inflammation. An unintended side effect of GC therapy is the stimulation of skeletal muscle atrophy. Pathophysiological mechanisms responsible for GC-induced skeletal muscle atrophy have been extensively investigated, and the ability to treat patients with GC without unintended muscle atrophy has yet to be realized. We have reported that a single, standard-of-care dose of Methylprednisolone increases in vivo expression of NF-κB-inducing kinase (NIK), an important upstream regulatory kinase controlling NF-κB activation, along with other key muscle catabolic regulators such as Atrogin-1 and MuRF1 that induce skeletal muscle proteolysis. Here, we provide experimental evidence that overexpressing NIK by intramuscular injection of recombinant human NIK via adenoviral vector in mouse tibialis anterior muscle induces a 30% decrease in the average fiber cross-sectional area that is associated with increases in mRNA expression of skeletal muscle atrophy biomarkers MuRF1, Atrogin-1, myostatin and Gadd45. A single injection of GC induced NIK mRNA and protein within 2 h, with the increased NIK localized to nuclear and sarcolemmal locations within muscle fibers. Daily GC injections induced skeletal muscle fore limb weakness as early as 3 days with similar atrophy of muscle fibers as observed with NIK overexpression. NIK overexpression in primary human skeletal muscle myotubes increased skeletal muscle atrophy biomarkers, while NIK knockdown significantly attenuated GC-induced increases in NIK and Atrogin-1. These results suggest that NIK may be a novel, previously unrecognized mediator of GC-induced skeletal muscle atrophy.
The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. (1995)

We report overexpression of the proto-oncogene bcl-2 in gastrointestinal adenocarcinoma and its precursor lesions. The bcl-2 proto-oncogene is centrally involved in the oncogenesis of human follicular lymphoma via a chromosomal translocation t(14;18)(q32;q21) and is also expressed in the epithelial regenerative compartment or the basal crypts of the normal colon and small intestine. We describe an immunohistochemical analysis of fixed, paraffin-embedded tissue using both a polyclonal rabbit and a monoclonal mouse antibody to the Bcl-2 protein. In addition to confirming bcl-2 expression in normal colonic and small intestinal crypts, we also observed expression in the gastric epithelial regenerative compartment, the mucous neck region. No increased expression was found in nonneoplastic or inflammatory gastrointestinal conditions, including ulcerative colitis, Crohn's disease, or inflammatory or hamartomatous polyps. Increased bcl-2 expression, however, was present in hyperplastic colonic polyps and in the majority of dysplastic lesions, from the earliest precursors through large adenomas, high grade flat dysplasia, and adenocarcinoma, all in comparison with adjacent internal control normal epithelium. Increased expression was present in dysplastic glandular lesions from all gastrointestinal sites, including colon, small bowel, and stomach. Furthermore, bcl-2 expression was frequently abnormal in nondysplastic epithelium surrounding dysplastic lesions, suggesting that altered expression occurred before the development of morphological dysplasia. Specifically, directly contiguous morphologically nondysplastic epithelium often showed abnormal bcl-2 expression throughout the full length of the crypt-villus axis. This expression pattern gradually diminished to involve only the crypt base (the normal pattern of expression), proceeding away from malignant or dysplastic lesions. Abnormal bcl-2 immunoreactivity in 1), the earliest precursor dysplastic lesions and its persistence throughout neoplastic progression and 2), contiguous morphologically unaltered nondysplastic epithelium suggests that bcl-2 alterations occur early during the morphological and molecular sequence of events leading to gastrointestinal epithelial neoplasia.