gebhart/patrepeval huggingface dataset:
A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5‐ht7 receptor in rat brain (1996)

1. Receptor autoradiography and in situ hybridization histochemistry have been used to delineate the distribution of the 5-ht7 receptor and its mRNA in rat brain. Receptor autoradiographic studies were performed using [3H]-5-carboxamidotryptamine (5-CT) as the radioligand. The binding characteristics of the masking compounds were determined in Cos-7 cells transfected with a panel of 5-HT receptor subtype cDNAs, including the rat 5-ht7 cDNA. In situ hybridization studies were carried out with 35S-labelled oligonucleotide probes to the rat 5-ht7 mRNA. 2. Specific binding of [3H]-5-CT was observed in many areas of the rat brain. Following co-incubation with 1 microM ergotamine, this binding was completely eliminated. After addition of the masking ligands, [3H]-5-CT binding remained in layers 1-3 of cortex, septum, globus pallidus, thalamus, hypothalamus, centromedial amygdala, substantia nigra, periaquaductal gray, and superior colliculus. Addition of the antagonist, methiothepin, to the incubation regimen eliminated most of the remaining [3H]-5-CT binding in the brain, with the exception of the globus pallidus and substantia nigra. 3. The 5-ht7 mRNA was discretely localized in rat brain. The most intense hybridization signals were observed over the thalamus, the anterior hippocampal rudiment, and over the CA3 region of the hippocampus. Other regions containing hybridization signals included the septum, the hypothalamus, the centromedial amygdala and the periaquaductal gray. The regions exhibiting a modest receptor binding signal after methiothepin incubation, the globus pallidus and the substantia nigra, contained no 5-ht7 hybridization signals, suggesting a non-5-ht7 subtype in these two related structures. 4. The distribution of the 5-ht7 receptor and its mRNA is suggestive of multiple roles for this novel 5-HT receptor, within several brain systems. The limbic system (centromedial amygdala, anterior hippocampal rudiment, hypothalamus) is particularly well-represented, indicating a potential role for the 5-ht7 receptor in affective processes.
M (1992)

Magnetic resonance spectroscopy (MRS) is a technique that permits chemically specific, noninvasive measurement of some compounds of biological importance in living tissue. MRS methods applicable to the study of functioning brain in vivo are new, and many scientists may not be familiar with them. Interested readers can gain access to the literature of the subject through the works listed under Further Reading.
LinkDroid: reducing unregulated aggregation of app usage behaviors (2015)

Usage behaviors of different smartphone apps capture different views of an individual's life, and are largely independent of each other. However, in the current mobile app ecosystem, a curious party can covertly link and aggregate usage behaviors of the same user across different apps. We refer to this as unregulated aggregation of appusage behaviors. In this paper, we present a fresh perspective of unregulated aggregation, focusing on monitoring, characterizing and reducing the underlying linkability across apps. The cornerstone of our study is the Dynamic Linkability Graph (DLG) which tracks applevel linkability during runtime. We observed how DLG evolves on real-world users and identified real-world evidence of apps abusing IPCs and OS-level identifying information to establish linkability. Based on these observations, we propose a linkability-aware extension to current-mobile operating systems, called LinkDroid, which provides runtime monitoring and mediation of linkability across different apps. LinkDroid is a client-side solution and compatible with the existing smartphone ecosystem. It helps end-users sense this emerging threat and provides them intuitive opt-out options.
Resistance degradation behavior of Ba0.7Sr0.3TiO3 thin films compared to mechanisms found in titanate ceramics and single crystals (1998)

Abstract The resistance degradation behavior of Ba0.7Sr0.3TiO3 (BST) and SrTiO3 (ST) thin films is compared to the degradation behavior of titanate single crystals and ceramics with respect to the dependence on parameters such as temperature, thickness of the sample, applied voltage, acceptor dopant concentration and electrode material. Different model considerations to explain the resistance degradation in titanate thin films are discussed. Key Words: Resistance degradationBSTthin film
Regulation of Gene Expression by Small RNAs (2009)

New Findings Revolutionize Concepts of Gene FunctionEndogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 p
Mapping the human plasma proteome by SCX-LC-IMS-MS (2007)

The advent of on-line multidimensional liquid chromatography-mass spectrometry has significantly impacted proteomic analyses of complex biological fluids such as plasma. However, there is general agreement that additional advances to enhance the peak capacity of such platforms are required to enhance the accuracy and coverage of proteome maps of such fluids. Here, we describe the combination of strong-cation-exchange and reversed-phase liquid chromatographies with ion mobility and mass spectrometry as a means of characterizing the complex mixture of proteins associated with the human plasma proteome. The increase in separation capacity associated with inclusion of the ion mobility separation leads to generation of one of the most extensive proteome maps to date. The map is generated by analyzing plasma samples of five healthy humans; we report a preliminary identification of 9087 proteins from 37,842 unique peptide assignments. An analysis of expected false-positive rates leads to a high-confidence identification of 2928 proteins. The results are catalogued in a fashion that includes positions and intensities of assigned features observed in the datasets as well as pertinent identification information such as protein accession number, mass, and homology score/confidence indicators. Comparisons of the assigned features reported here with other datasets shows substantial agreement with respect to the first several hundred entries; there is far less agreement associated with detection of lower abundance components.
Modification of Photoluminescence via Strong Coupling of Vibronic Transitions in Organic Molecules to Surface Plasmons (2018)

We demonstrate redistribution of the spectral intensities of the luminescence associated with different vibronic transitions in organic molecule, Diindenoperylene through strong coupling of excitons to surface plasmons.
2D Nmr Study of Residual Lignin in Beech Kraft Pulp Combined with Selective Cleavage with Pivaloyl Iodide (1992)

ABSTRACT Structures of acetylated residual lignin obtained from unbleached beech kraft pulp were investigated by 2D NMR in combination with selective cleavage of non-phenolic α-alkyl ether bonds with pivaloyl iodide generated in situ from pivaloyl chloride / sodium iodide. β-O-4 and resinol structures still remained in this polymer lignin. Furthermore, carbohydrates were proved to be linked glycosidically to benzyl carbons of lignin. Possibly this inhibits complete delignification during kraft pulping.
Bonding Pad Over Active Structure for Chip Shrinkage of High-Power AlGaN/GaN HFETs (2015)

This paper reports a bonding pad over active (BPOA) structure with photosensitive polyimide (PSPI) as the intermetal dielectric layer to reduce the chip size of high-power enhancement-mode AlGaN/GaN heterojunction FETs (HEFTs) on a 150-mm (6-in) Si substrate. The fabricated AlGaN/GaN HFETs with a BPOA structure exhibited a threshold voltage and a maximum current of 0.6 V and 38.6 A, respectively, at VGS of 6 V. The leakage current was 4.3 × 10-5 A at 700 V, which was the same value as that of the AlGaN/GaN HFETs without a BPOA structure. The reliability of the AlGaN/GaN HFETs with the BPOA structure during the packaging process was improved by the PSPI layer and a modified bonding pad structure, which endured the stress during the wedge wire bonding and epoxy molding processes.
A High-Performance Generalized (1998)

In this paper, a generalized discontinuous pulsewidth modulation (GDPWM) method with superior high modulation operating range performance characteristics is developed. An algorithm which employs the conventional space-vector PWM method in the low modulation range, and the GDPWM method in the high modulation range, is established. As a result, the current waveform quality, switching losses, voltage linearity range, and the overmodulation region performance of a PWM voltage-source inverter (PWM-VSI) drive are on-line optimized, as opposed to conventional modulators with fixed characteristics. Due to its compactness, simplicity, and superior performance, the algorithm is suitable for most high-performance PWM-VSI drive applica- tions. This paper provides detailed performance analysis of the method and compares it to the other methods. The experimental results verify the superiority of this algorithm to the conventional PWM methods.
Off-Target Effect of Sildenafil on Postsurgical Erectile Dysfunction: Alternate Pathways and Localized Delivery System (2016)

Sildenafil showed the most profound neuroprotective effect compared with tadalafil and vardenafil. Sildenafil- or rolipram-loaded NSP delivery to the site of nerve injury prevented erectile dysfunction and led to increased neurofilament, nitric oxide synthase, smooth muscle content in rat penile tissue after BCNI.
Analysis of the Interaction of the Novel RNA Polymerase II (pol II) Subunit hsRPB4 with Its Partner hsRPB7 and with pol II (1998)

Under conditions of environmental stress, prokaryotes and lower eukaryotes such as the yeast Saccharomyces cerevisiae selectively utilize particular subunits of RNA polymerase II (pol II) to alter transcription to patterns favoring survival. In S. cerevisiae, a complex of two such subunits, RPB4 and RPB7, preferentially associates with pol II during stationary phase; of these two subunits, RPB4 is specifically required for survival under nonoptimal growth conditions. Previously, we have shown that RPB7 possesses an evolutionarily conserved human homolog, hsRPB7, which was capable of partially interacting with RPB4 and the yeast transcriptional apparatus. Using this as a probe in a two-hybrid screen, we have now established that hsRPB4 is also conserved in higher eukaryotes. In contrast to hsRPB7, hsRPB4 has diverged so that it no longer interacts with yeast RPB7, although it partially complements rpb4- phenotypes in yeast. However, hsRPB4 associates strongly and specifically with hsRPB7 when expressed in yeast or in mammalian cells and copurifies with intact pol II. hsRPB4 expression in humans parallels that of hsRPB7, supporting the idea that the two proteins may possess associated functions. Structure-function studies of hsRPB4-hsRPB7 are used to establish the interaction interface between the two proteins. This identification completes the set of human homologs for RNA pol II subunits defined in yeast and should provide the basis for subsequent structural and functional characterization of the pol II holoenzyme.
Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro (1999)

We have grown expanded populations of epidermal growth factor (EGF)-responsive mouse striatal precursor cells and subsequently co-cultured these with primary E14 rat ventral mesencephalon. The aim of these experiments was to induce dopaminergic (DA) neuronal phenotypes from the murine precursors. While no precursor cell-derived neurons were induced to express tyrosine hydroxylase (TH), there was a dramatic 30-fold increase in the survival of rat-derived TH-positive neurons in the co-cultures. The effect was not explicable solely in terms of total plating density, and was accompanied by a significantly enhanced capacity for [3H]dopamine uptake in the co-cultures compared to rat alone cultures. The present data show that, although primary rat E14 mesencephalic cells are incapable of inducing the development of DA neurons from EGF-responsive mouse neural precursor cells, such precursors will differentiate into cells capable of enhancing the survival and overall functional efficacy of primary embryonic dopamine neurons.
ChemInform Abstract: Pillared Smectite Clay Coatings for Ceramic‐Matrix Composites. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Implementation and Use of a Manual Multi-Rule Quality Control Procedure (1985)

Journal Article Implementation and Use of a Manual Multi-Rule Quality Control Procedure Get access H. Elizabeth Broome, MD, H. Elizabeth Broome, MD Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the William Pepper Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104. Search for other works by this author on: Oxford Academic PubMed Google Scholar George S. Cembrowski, MD, PhD, George S. Cembrowski, MD, PhD Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the William Pepper Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sidney N. Kahn, MB, PhD, Sidney N. Kahn, MB, PhD Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the William Pepper Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104. Search for other works by this author on: Oxford Academic PubMed Google Scholar Penny L. Martin, MT(ASCP), Penny L. Martin, MT(ASCP) Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the William Pepper Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104. Search for other works by this author on: Oxford Academic PubMed Google Scholar Carol A. Patrick Carol A. Patrick Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and the William Pepper Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 16, Issue 9, 1 September 1985, Pages 533–537, https://doi.org/10.1093/labmed/16.9.533 Published: 01 September 1985
Metabolism of Monoterpenes (1987)

The bicyclic monoterpene ketone (+)-camphor undergoes lactonization to 1,2-campholide in mature sage (Salvia officinalis L.) leaves followed by conversion to the beta-d-glucoside-6-O-glucose ester of the corresponding hydroxy acid (1-carboxymethyl-3-hydroxy-2,2,3-trimethyl cyclopentane). Analysis of the disposition of (+)-[G-(3)H]camphor applied to midstem leaves of intact flowering plants allowed the kinetics of synthesis of the bis-glucose derivative and its transport from leaf to root to be determined, and gave strong indication that the transport derivative was subsequently metabolized in the root. Root extracts were shown to possess beta-glucosidase and acyl glucose esterase activities, and studies with (+)-1,2[U-(14)C]campholide as substrate, using excised root segments, revealed that the terpenoid was converted to lipid materials. Localization studies confirmed the radiolabeled lipids to reside in the membranous fractions of root extracts, and analysis of this material indicated the presence of labeled phytosterols and labeled fatty acids (C(14) to C(20)) of acyl lipids. Although it was not possible to detail the metabolic steps between 1,2-campholide and the acyl lipids and phytosterols derived therefrom because of the lack of readily detectable intermediates, it seemed likely that the monoterpene lactone was degraded to acetyl CoA which was reincorporated into root membrane components via standard acyl lipid and isoprenoid biosynthetic pathways. Monoterpene catabolism thus appears to represent a salvage mechanism for recycling mobile carbon from senescing oil glands on the leaves to the roots.
Application of streamer criteria for calculations of flashover voltages of gaseous insulation with solid dielectric barrier (2013)

Streamer inception and propagation criteria are used for evaluations of ac breakdown voltages of sphere-sphere gaps employing a dielectric barrier in dry air. For such an arrangement, an optimal location of the barrier is expected to exist providing maximum value of the breakdown voltage. To reproduce the barrier effect, different calculation approaches are considered including models based on undisturbed electrostatic field distributions and models accounting for charging of the barrier due to a pre-breakdown streamer. The breakdown voltages calculated for different positions of the barrier in the inter-electrode gap are examined and are compared with the results of the\nmeasurements. It is revealed that charges on barrier surfaces have to be considered when using the streamer criterion for a quantitative prediction of the barrier effect.
Figure S3. Inhibition of histone acetyl transferase (HAT). from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma (2023)

&lt;p&gt;Inhibition of HAT with C646 resulted in decreased histone acetylation and Myc expression in L428 (HL) and Jurkat (TCL) cells on Western blot.&lt;/p&gt;
An Endoluminal Method of Hemorrhage Control and Repair of Ruptured Abdominal Aortic Aneurysms (2000)

Endovascular repair of ruptured aortic aneurysms is feasible. Proximal aortic control is readily attainable with the use of an aortic occlusion balloon placed through the left axillary artery. The absence of a laparotomy, extensive retroperitoneal dissection, and aortic cross-clamping likely contributes to patient survival; however, the delay in operative therapy to obtain adequate imaging and construct an endograft could be a hindrance to the ultimate success of this approach. The concepts of alternative aortic imaging techniques and endograft design, construction, and storage must be addressed.
Role of biomarkers in monitoring antiblastic cardiotoxicity (2016)

Early detection of anticancer drug-induced cardiotoxicity (CTX) has been evaluated by most international scientific cardiology and oncology societies. High expectations have been placed on the use of specific biomarkers. In recent years, conventional biomarkers and molecules of more recent interest have been tested and compared in the context of anticancer drug-related CTX. Encouraging results were obtained from studies on molecules of myocardial damage, such as troponin and markers of myocardial wall stress, including circulating natriuretic peptides, as well as from the assessment of the products of inflammation or circulating levels of free radicals. However, clear guidelines on their sensitivity, specificity, and accuracy are not yet available, and many challenges, such as the optimal time of assessing, optimal schedule for evaluation, optimal cut-off point for positivity with the highest level of specificity, and optimal comparability of different assays for the measurements, remain unresolved. Given the importance of having a reliable and accurate tool for monitoring anticancer drug-induced CTX, this review will focus on the available data on the most effective and widely used biomarkers and the studies that are currently underway that aim to identify the effectiveness of new approaches in this therapeutic setting.
THE QUASI-CHEMICAL KINETICS MODEL FOR THE INACTIVATION OF MICROBIAL PATHOGENS USING HIGH PRESSURE PROCESSING (2005)

ISHS III International Symposium on Applications of Modelling as an Innovative Technology in the Agri-Food Chain; MODEL-IT THE QUASI-CHEMICAL KINETICS MODEL FOR THE INACTIVATION OF MICROBIAL PATHOGENS USING HIGH PRESSURE PROCESSING
GENETIC STUDIES ON THREE STALK TRAITS IN MAIZE USING CHROMOSOMAL INTERCHANGES (1979)

Yield losses due to stalk-lodging in maize (Zea mays L.) have been estimated at 5 to 25% annually. Information on chromosomal arms carrying gene(s) favorable to stalk-quality improvement would be useful to maize breeders. Reciprocal chromosomal translocations (interchanges) were used to locate genes for three stalk-quality traits, viz, stalk-section weight, crushing strength, and rind thickness, in two inbred lines (B14A and B37) with excellent stalk-quality, using two testers (Oh43 and N31) with poor stalk-quality. Genes conditioning stalk-section weight were located in nearly all the ten linkage groups. Six and seven chromosome arms were found to carry gene(s) for stalk crushing strength in B14A and B37, respectively. Rind thickness was found to be controlled by four chromosome arms in B37 and possibly by two arms in B14A. This information may be helpful to maize breeders in improving stalk-quality in maize by transferring favorable chromosome arms by means of chromosomal interchanges. Certain chromosome arms could not be conclusively ruled out. Additional translocations involving each of the following chromosome arms should be studied for this purpose: 1L, 3L, 5S, 6S, 8S, 10S, and 10L. The shriveled (semi-sterile) versus non shriveled (fertile) anther classification method could be reliably used to determine semi-sterility and fertility in a normal growing season.
Enhancing LTE-Advanced Relay Deployments via Relay Cell Extension (2011)

Relaying is a promising enhancement to current radio access networks. Relay enhanced LTE-Advanced networks are expected to fulfill the demanding coverage and capacity requirements in a cost-efficient way. However, due to low transmit power, the coverage areas of the relay nodes will be small. Therefore, the performance of relay deployments may be limited by load imbalances. In this study, we present a practical solution for this problem by introducing a bias to cell selection and handover decisions along with a reduction in eNB transmit power. This method results in an extension of the relay cells and an appropriate load balance can then be achieved. Moreover, it is shown that a proper power control setting is necessary in the uplink and that power control optimization can further enhance the system performance. Comprehensive system level simulations confirm that the proposed solution yields significant user throughput gains both in the uplink and the downlink.
Topography of the Distal Tibial Nerve and Its Branches (2003)

The tibial nerve trunk and its branches were dissected in 20 embalmed cadaver legs and the relative topographic anatomy was defined at 3-cm intervals up to 15 cm proximal to the medial malleolar-calcaneal (MMC) axis. Each nerve branch was found in various locations. The calcaneal nerve was found to descend from medial to posteromedial. It was never found anterolaterally and only rarely laterally. The lateral plantar nerve was found to rotate externally from lateral and posterolateral to lateral and posteromedial as it descends. This nerve was not found medially or anteromedially. The first branch of the lateral plantar nerve was indistinguishable from the trunk of the tibial nerve descending medially to between the lateral plantar and calcaneal nerves. The overall pattern of the medial plantar nerve was an internal rotation from anteromedial (proximal) to anterior (distally). It was not found posteriorly. The flexor hallucis longus motor branch was located an average of 17.9 cm (range, 10-24 cm) proximal to the MMC axis. Preliminary application of these data has facilitated surgical dissection and afforded an understanding of how tibial nerve trunk pathology correlates with clinical manifestations.