gebhart/patrepeval huggingface dataset:
Preparation of a "stabilized formyl" complex from carbon monoxide and hydrogen and the crystal structure of a derivative in which the carbon-oxygen bond has been cleaved (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of a "stabilized formyl" complex from carbon monoxide and hydrogen and the crystal structure of a derivative in which the carbon-oxygen bond has been cleavedPatricia Belmonte, Richard R. Schrock, Melvyn Rowen Churchill, and Wiley J. YoungsCite this: J. Am. Chem. Soc. 1980, 102, 8, 2858–2860Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ja00528a067https://doi.org/10.1021/ja00528a067research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the channel capacity of polarization-multiplexed coherent radio-over-fiber transmissions at millimeter-wave bands (2016)

A closed-form capacity expression for polarization-multiplexed coherent MIMO radio-over-fiber (RoF) links at millimeter-wave bands is derived and the impact of the fiber's polarization rotation and the wireless antenna misalignment on the MIMO channel capacity is revealed. The analytical results are validated via an indoor W-band (75-110 GHz) 10-Gbaud MIMO-RoF transmission experiment.
A nonuniform cartesian grid algorithm for fast field evaluation on elongated domains (2011)

A fast algorithm for field evaluation of time harmonic fields of two-dimensional source constellation with elongated geometry is presented. The algorithm relies on sampling the phase- and amplitude - compensated fields produced by finite size radiating sources. Such fields behave as essentially bandlimited functions, which can be sampled over sparse nonuniform left- and right - Cartesian grids. These grids are employed for both outgoing and incoming fields. Henceforth, the algorithm uses hierarchical subdivision of the complete scatterer into a binary tree of sub-domains. The required fields are gradually aggregated via a multilevel process passing up and down the tree. The algorithm attains linear computational complexity.
Compact Multifunctional Gain Enhancing GRIN Lens for Widely Separated Frequency Band Shared Aperture Antennas (2023)

Abstract Gradient index (GRIN) lenses embody a powerful technology that enables control of electromagnetic wave propagation over wide frequency bands. However, GRIN lenses that achieve multifunctional ( i.e ., dual broadband) performance have not been realized mainly due to the limitations of conventional techniques such as Transformation Optics (TO). This paper proposes a multi‐objective inverse‐design approach for the optimization of multi‐band GRIN lenses with highly constrained aperture sizes. A candidate lens design is fabricated from a ceramic material using a new additive manufacturing approach allowing for spatially‐varying permittivities between 2–6.5 to be achieved at sub‐cm resolution. Measured results validate the candidate functionalized ceramic GRIN lens's simulated multi‐band performance and demonstrate the efficacy of the proposed inverse‐design procedure.
Uniform Amplification of Phage with Different Growth Characteristics in Individual Compartments Consisting of Monodisperse Droplets (2010)

Jeder Klon zählt! Beim Phagen-Display gehen Klone, die das Phagenwachstum hemmende Liganden präsentieren, bei der Vervielfältigung verloren. In monodispersen Emulsionen, die mithilfe eines einfachen Mikrofluidiksystems erzeugt wurden, ist die Konkurrenz zwischen langsam (S) und schnell (R) wachsenden Phagen abgemildert, sodass das R/S-Verhältnis beibehalten bleibt. Die konkurrenzfreie Vervielfältigung von Phagen bewahrt Liganden, die im normalen Phagen-Display abhanden kommen.
Non-spherical particle size and shape estimation using machine learning (2020)

A real time measurement of particles being ingested by gas turbines would prove useful for accurately monitoring engine health and ensuring safe operations. However, typical optical methods assume spherical particles, which most ingested particles are not. We present a novel application of machine learning models that takes scattering and extinction observations as inputs and estimates non-spherical particle shape (via aspect ratio) and size. The overall method of multiple classification and regression layers, as well as the results from three test cases using simulated inputs are presented.
Transplantation and gene transfer of the human glucocerebrosidase gene into immunoselected primate CD34+Thy-1+ cells (1996)

In an attempt to improve our gene transfer efficiency into hematopoietic stem cells and to evaluate the capacity of immunoselected CD34+Thy-1+(CDw90) cells to reconstitute hematopoiesis following myeloablation, bone marrow (BM) transplantation was performed using autologous, immunoselected CD34+Thy-1+ cells in rhesus macaques. BM samples were positively selected for cells that express CD34, further subdivided using high gradient immunomagnetic selection for cells that express Thy-1, and transduced using a 7-day supernatant transduction protocol with a replication-defective retroviral vector that contained the human glucocerebrosidase (GC) gene. Circulating leukocytes were evaluated using a semiquantitative polymerase chain reaction (PCR) assay for the human GC gene, with the longest surviving animal evaluated at day 558. Provirus was detected at all time points in both CD20+ B cells and CD2+ dim T cells, but long-term gene transfer was not observed in the granulocyte population. The CD2+ dim population was phenotypically identified as being CD8+ natural killer cells. By day 302 and day 330, both the CD2+ bright and dim cell populations and sorted CD4+ and CD8+ cells had detectable provirus. Vector-derived GC mRNA was detected by reverse transcriptase (RT)-PCR analysis as far out as day 588. Thus, CD34+Thy-1+ cells isolated using high gradient magnetic separation techniques can engraft, be transduced with a replication-defective retroviral vector, and contribute to CD20+ B lymphocytes, CD8+ T lymphocytes, and CD4+ T lymphocytes; making them a suitable cell population to target for gene therapies involving lymphocytes.
Antenne guide d’onde à réseau de fentes à haute efficacité pour communications sans fil en bande V (2015)

National audience
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Library Design and High-Throughput Synthesis and Screening (2003)

Novel 2,4-diaminopyrimidines bearing N,N-disubstituted aminomethyl residues at the 5-position were designed as dihydrofolate reductase (DHFR) inhibitors. These compounds were obtained by treatment of 1-[(2,4-diamino-5-pyrimidinyl)methyl]pyridinium bromide with secondary amines in a polar solvent and in the presence of triethylamine at room temperature. The procedure was found to be very efficient and suitable for application in high-throughput synthesis. In addition, we found that high-throughput screening for enzymatic and in vitro antibacterial activity could be performed on crude reaction mixtures, thus avoiding any purification step. Over 1200 proprietary secondary amines were selected for high-throughput synthesis, based on structural and diversity-related criteria, and the resulting products were submitted to high-throughput screening. A greater number of hits, and significantly more active compounds, were obtained through structure-based library design than through diversity-based library design. Different classes of inhibitors of DHFR were identified in this way, including compounds derived from di-, tri-, and tetracyclic amines. In general, these products showed high activity against the enzymes derived from both TMP-sensitive and TMP-resistant Streptococcus pneumoniae. Some compounds possessed appreciable selectivity for the bacterial over the human enzyme, whereas other compounds were not at all selective. In most cases, active enzyme inhibitors also displayed antibacterial activity.
ChemInform Abstract: Low Temperature, Aerosol‐Assisted Chemical Vapor Deposition (AACVD) of CdS, ZnS, and Cd1‐xZnxS Using Monomeric Single‐Source Precursors: M( SOCCH3)2TMEDA. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SPEC: Seeing People in the Wild with an Estimated Camera (2021)

Due to the lack of camera parameter information for in-the-wild images, existing 3D human pose and shape (HPS) estimation methods make several simplifying assumptions: weak-perspective projection, large constant focal length, and zero camera rotation. These assumptions often do not hold and we show, quantitatively and qualitatively, that they cause errors in the reconstructed 3D shape and pose. To address this, we introduce SPEC, the first in-the-wild 3D HPS method that estimates the perspective camera from a single image and employs this to reconstruct 3D human bodies more accurately. First, we train a neural network to estimate the field of view, camera pitch, and roll given an input image. We employ novel losses that improve the calibration accuracy over previous work. We then train a novel network that concatenates the camera calibration to the image features and uses these together to regress 3D body shape and pose. SPEC is more accurate than the prior art on the standard benchmark (3DPW) as well as two new datasets with more challenging camera views and varying focal lengths. Specifically, we create a new photorealistic synthetic dataset (SPEC-SYN) with ground truth 3D bodies and a novel in-the-wild dataset (SPEC-MTP) with calibration and high-quality reference bodies. Code and datasets are available for research purposes at https://spec.is.tue.mpg.de/.
Abstract 1846: Catalytic topoisomerase II inhibitors suppress the androgen receptor signaling and prostate cancer progression (2015)

Abstract Background: Although the new generation of anti-androgens (e.g. MDV) improves survival of metastatic prostate cancer patients, tumors eventually recur indicating that additional therapeutic means is required to fully block the functions of the androgen receptor (AR). Since DNA topoisomerase II (Topo II) was demonstrated to be essential for AR to initiate gene transcription, this study tested whether catalytic inhibitors of Topo II can suppress the AR signaling and block prostate tumor growth. Methods and Results: Androgen-dependent and MDV-resistant prostate cancer cells were treated with increasing doses of catalytic Topo II inhibitors, ICRF187 and ICRF193. Luciferase reporter assays showed that both inhibitors suppressed the transcriptional activities of wild-type AR, mutant AR (F876L and W741C), and AR-V7 splice variant. ICRF187 and ICRF193 decreased AR recruitment to its target promoters and reduced AR nuclear localization. Both ICRF187 and ICRF193 inhibited androgen-dependent and MDV-resistant cancer cell proliferation and delayed cell cycling at the G2/M stages. In castration-resistant LNCaP tumors, ICRF187 inhibited tumor growth, PSA secretion and expressions of several other AR regulated genes. These repressive effects became stronger when tumors were co-treated with MDV. Additionally, ICRF187 effectively inhibited tumor growth of MDV-resistant MR49F as well as castration-resistant 22RV1 xenografts. Conclusions: Catalytic Topo II inhibitors can block the AR signaling and inhibit tumor growth of castration-resistant xenografts, suggesting their potential applications in treating castration-resistant cancers in patients. Citation Format: Haolong Li, Ning Xie, Martin Gleave, Xuesen Dong. Catalytic topoisomerase II inhibitors suppress the androgen receptor signaling and prostate cancer progression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1846. doi:10.1158/1538-7445.AM2015-1846
The GluN2B‐Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand‐unbinding and domain opening (2018)

N-methyl-D-aspartate (NMDA) receptors are transmembrane glutamate-binding ion channels that mediate neurotransmission in mammals. NMDA receptor subunits are tetrameric complexes of GluN1 and GluN2A-D subunits, encoded by the GRIN gene family. Of these subunits, GluN2B is suggested to be required for normal development of the central nervous system. A mutation identified in a patient with developmental delay, E413G, resides in the GluN2B ligand-binding domain and substantially reduces glutamate potency by an unknown mechanism. GluN2B Gly413, though near the agonist, is not in van der Waals contact with glutamate. Visual analysis of the GluN2B structure with the E413G mutation modeled suggests that replacement of Glu with Gly at this position increases solvent access to the ligand-binding domain. This was confirmed by molecular modeling, which showed that the ligand is more mobile in GluN2B-E413G than WT GluN2B. Evaluation of agonist occupancy using random accelerated molecular dynamics (RAMD) simulations predicts that the glutamate exits the binding-site more rapidly for GluN2B-E413G than WT receptors. This analysis was extended to other binding-site mutations, which produced qualitative agreement between experimentally determined EC<sub>50</sub> values, deactivation time constants, and ligand motion within the binding-site. Furthermore, long sub-microsecond molecular dynamics simulations of the bi-lobed ligand-binding domain revealed that it adopted a cleft-open ligand-free state more often for GluN2B-E413G than wild-type GluN2B. This is consistent with the idea that L-glutamate binding is altered such that the ligand-binding domain occupies the open-cleft conformation associated with the closed channel.
FRE: A Fast Method For Anomaly Detection And Segmentation (2022)

This paper presents a fast and principled approach for solving the visual anomaly detection and segmentation problem. In this setup, we have access to only anomaly-free training data and want to detect and identify anomalies of an arbitrary nature on test data. We propose the application of linear statistical dimensionality reduction techniques on the intermediate features produced by a pretrained DNN on the training data, in order to capture the low-dimensional subspace truly spanned by said features. We show that the \emph{feature reconstruction error} (FRE), which is the $\ell_2$-norm of the difference between the original feature in the high-dimensional space and the pre-image of its low-dimensional reduced embedding, is extremely effective for anomaly detection. Further, using the same feature reconstruction error concept on intermediate convolutional layers, we derive FRE maps that provide pixel-level spatial localization of the anomalies in the image (i.e. segmentation). Experiments using standard anomaly detection datasets and DNN architectures demonstrate that our method matches or exceeds best-in-class quality performance, but at a fraction of the computational and memory cost required by the state of the art. It can be trained and run very efficiently, even on a traditional CPU.
Cell Killing By Enveloped Rna Viruses (2018)

The ability of a virus to kill the host cell or to inhibit normal cellular functions underlies the pathological basis for many viral diseases. The death of cells infected with various lytic animal viruses probably represents the culmination of many structural, metabolic, and biosynthetic lesions within the infected cells. Sindbis virus and Semliki Forest virus, prototypes of the alphavirus group of the togavirus family, are small, enveloped plus-stranded ribonucleic acid viruses. Virus-induced damage to the cell membrane may occur as a consequence of envelope glycoprotein insertion and virus budding. The inhibition of host macromolecular synthesis and the induction of cell injury are not necessarily independent mechanisms that lead to cell death. L. Carrasco has shown that virus infection renders the cell membrane permeable to toxins and phosphorylated intermediates of metabolism. The induction of cell injury by rhabdoviruses is primarily due to the inherent toxicity of virion components.
Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache (2018)

Prolonged exposure to migraine treatments followed by an acute nociceptive stimulation caused long-lasting alterations in descending pain modulation, shown by a loss of diffuse noxious inhibitory controls. Morphine was more detrimental than sumatriptan, consistent with clinical observations of higher medication overuse headache risk with opioids. These data suggest a mechanism of medication overuse headache by which migraine medications combined with repeated episodes of pain may amplify the consequences of nociceptor activation and increase the probability of future migraine attacks as well as risk of medication overuse headache.
Novel Cell Architectures with Back-side Transistor Contacts for Scaling and Performance (2023)

PowerVia increases the efficiency of power delivery by adding back-side interconnects [1]. It also improves performance by relaxing the minimum front-side interconnect pitch and by optimizing them for signaling. Research to further improve performance and density synergistically with PowerVia includes back-side device contacts and device stacking. In this paper, we present an experimental demonstration of a novel cell architecture with back-side device contacts and back side power delivery. Keywords: back-side power delivery, back-side contacts, BSCON.
Chronic autonomic regulation therapy mitigates adverse remodeling induced by myocardial infarction in the guinea pig heart (2013)

Background: Myocardial infarction (MI) is associated with adverse remodeling of the cardiac neurohumoral control systems as well as ventricular structure and function. The objective of this study was to determine whether chronic autonomic regulation therapy (ART) could attenuate such adverse remodeling, thereby preserving contractile function. Methods: Guinea pigs were implanted with a vagus nerve stimulation (VNS) system on the right cervical vagus (n=6). Two weeks later, MI was produced by ligation of the coronary artery and associated vein on the dorsal surface of the heart. The ART treatment group was stimulated at 20 Hz, 0.9±0.2 mA pulse amplitude, 14 s ON, 48 s OFF for 90 days and compared to time matched MI guinea pigs that received no VNS therapy (MI Control, n=6). Echo cardiograms were performed before MI and at 90 days post MI. At termination, intracellular voltage recordings were obtained in whole mounts of the cardiac neuronal plexus to determine passive and active neuronal properties, as well as the synaptic efficacy of intrinsic cardiac (IC) neurons. Results: Left ventricular end systolic volume (LVESV) for MI controls increased 30% (p=0.027) and LV ejection fraction (EF) decreased 7% (p<0.001) at 90 days post MI, compared to their baseline level. In the ART group exposed to chronic VNS, adverse remodeling of LV function was abolished and not different from baseline levels (c.f. Table 1). In the ART group, resting membrane potential of IC neurons was lower (MI -42.4±1.5 mV; MI+ART -49.7±3.2 mV; p<0.05) and the synaptic efficacy evoked when stimulating adjacent axons at 5 and 10 Hz was reduced compared to MI controls (p<0.05). The ratio of tonic and phasic neurons as well as the neuronal excitability when injecting depolarizing intracellular currents was similar between groups. Table 1 Conclusion: Chronic ART after MI abolished adverse LV functional remodeling and adverse upregulation of synaptic efficacy/network excitability within the intrinsic cardiac nervous system.
Development of a Coordination Chemistry‐Based Approach for Functional Supramolecular Structures (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Segment Routing Conflict Resolution (2016)

In support of Segment Routing (SR) routing protocols advertise a
variety of identifiers used to define the segments which direct
forwarding of packets. In cases where the information advertised by a
given protocol instance is either internally inconsistent or conflicts
with advertisements from another protocol instance a means of
achieving consistent forwarding behavior in the network is required.
This document defines the policies used to resolve these occurrences.
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy (2019)

Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high-resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1-asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment.