gebhart/patrepeval huggingface dataset:
Investigation of self-interaction processes from the statistical characteristics of the scattered field (1982)

A method is proposed for the experimental investigation of the integrated characteristics of an optical beam undergoing self-interaction in the propagation medium. The method is based on analyzing the spectrum of intensity fluctuations of the scattered radiation. An experimental investigation is reported of transient thermal self-interaction in a liquid. The method can be used to estimate the operating efficiency of adaptive radiation-focusing systems and in many other applications.
Quadric Transfer for Immersive Curved Screen Displays (2004)

Abstract Curved screens are increasingly being used for high‐resolution immersive visualization environments. We describe a new technique to display seamless images using overlapping projectors on curved quadric surfaces such as spherical or cylindrical shape. We exploit a quadric image transfer function and show how it can be used to achieve sub‐pixel registration while interactively displaying two or three‐dimensional datasets for a head‐tracked user. Current techniques for automatically registered seamless displays have focused mainly on planar displays. On the other hand, techniques for curved screens currently involve cumbersome manual alignment to make the installation conform to the intended design. We show a seamless real‐time display system and discuss our methods for smooth intensity blending and efficient rendering. Categories and Subject Descriptors (according to ACM CCS): I.3.7 [Computer Graphics]: Three‐Dimensional Graphics and Realism‐ Virtual reality
Reach Extension with 32- and 64 GBaud Single Carrier vs. Multi-Carrier Signals (2017)

We show that 32 GBaud single- and multi-carrier DP-QPSK can deliver longer reach for the same capacity as 64 GBaud DP-QPSK. However, 64 GBaud multi-carrier DP-QPSK signal can provide 12% longer reach than single-carrier 32 GBaud DP-QPSK.
p-cycle network design with hop limits and circumference limits (2004)

p-cycles offer an approach to protection of optical transport networks which is as fast as a ring-based network but with mesh-like capacity efficiency. One misconception about p-cycle designs seems to be that they involve long protection paths, even though it is trivial to limit the circumference of cycles admitted to the design problem. In addition, through straddling span considerations the average protection path on a p-cycle is actually shorter than in a corresponding ring. Nonetheless there are some open questions regarding path and cycle circumference limit effects with p-cycles. One question is whether p-cycle networks exhibit a "threshold hop-limit" effect corresponding to that well-known aspect of span-restorable mesh networks. (Beyond the threshold hop-limit there are negligible savings in capacity.) To study this question we extend the existing p-cycle network design theory to include the capability of direct restriction of protection path lengths, rather than indirect restriction through circumference limits. A second, quite practical question is to ask how well simple limitation of cycle circumferences serves as a surrogate for a more involved design method of directly asserting a hop (or distance) limit on the maximum length of protection paths. The answers to the questions and the methods developed to address them both enhance our ability to design p-cycle networks in which optically transparent length may affect transmission quality, or where the length of protection paths may affect cost if regeneration is required en route of a protection path. The main findings are that p-cycles do exhibit threshold hop-limiting effects (at about two or three hops above those in corresponding mesh networks) and that cycle limiting is a simple and effective surrogate for direct limitation on path lengths in p-cycle design problems.
Verbesserung von Ortsauflösung und Dynamik in der Ultraschallbildgebung durch tiefenabhängige Mismatched-Filter-Pulskompression (1997)

Article Verbesserung von Ortsauflösung und Dynamik in der Ultraschallbildgebung durch tiefenabhängige Mismatched-Filter-Pulskompression was published on January 1, 1997 in the journal Biomedical Engineering / Biomedizinische Technik (volume 42, issue s2).
Abstract 973: Targeting cancer stem cells by a novel anti-frizzled antibody inhibits pancreatic tumor growth and induces differentiation (2011)

Abstract Clinical management of pancreatic cancer over the past years has not been improved and this disease remains the fourth most common cause of cancer-related death. It has been suggested that cancer stem cells drive tumor growth and progression and are resistant to many current therapies. The WNT/beta-catenin pathway, which signals through the Frizzled (FZD) receptor family and co-receptors, plays an important role in regulating cell fate, stem cell self-renewal and maintenance. We have recently demonstrated that inhibition of WNT/beta-catenin pathway by an anti-FZD antibody 18R5 decreased tumorigenicity and induced differentiation in solid tumors. The present study evaluated the anti-tumor effect of OMP-18R5 in a panel of pancreatic tumors. In vivo studies using primary pancreatic xenograft tumor models showed that OMP-18R5 was efficacious against both high and low grade pancreatic tumors. Histologic and gene expression analyses indicated that the 18R5-mediated anti-tumor effect was associated with inhibition of WNT target genes while inducing of mucin expression and tumor cell differentiation. Furthermore, inclusion of OMP-18R5 delayed pancreatic tumor recurrence following termination of gemcitabine. The delay in tumor recurrence by OMP-18R5 treatment was associated with a decrease in cancer stem cell frequency. The combination of OMP-18R5 and gemcitabine further decreased cancer stem cell frequency compared to the single agents. Our findings provide a rationale to target cancer stem cells through interference with WNT/beta-catenin pathway as a therapeutic approach in pancreatic cancer treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 973. doi:10.1158/1538-7445.AM2011-973
Improvement of photofatigue resistance of spirooxazine entrapped in organic-inorganic composite synthesized via the sol-gel process (1994)

A photochromic dye, spirooxazine (SO), was incorporated in organic-inorganic composite (OIC) materials by the advantages of sol-gel processing. It has been found that the photochromic response is high enough and the fading rate is similar to the dye-in-ethanol solution while the photofatigue resistance is strongly dependent on the matrix composition and the starting compounds. In the present work, we present results on the effect of matrix composition and starting compounds as well as additives on the photofatigue resistance of SO- OIC photochromic coatings. Sol-gel coatings synthesized from methyltrimethoxysilane (MTMS) and glycidyloxypropyltrimethoxysilane (GPTMS) as starting compounds, and using 1H,1H,2H,2H-perfluoroalkyltrimethoxysilane (FAS) and 1-methylimidazole (MI) as additives provide the SO dye with a favorable matrix environment in terms of photofatigue, so that the overall photochromic performance of the dye can be optimized. The photofatigue resistance reaches the same level as, while both the photochromic response and fading rate are much better than the SO-PMMA coatings.
p-Type Electrical Transport of Chemically Doped Epitaxial Graphene Nanoribbons (2012)

We present the first demonstration of p-type electrical transport in chemically doped epitaxial graphene (EG) nanoribbons produced on silicon carbide (SiC). The thermal annealing of cross-linked thin films of hydrogen silsesquioxane (HSQ) is found to be capable of overcoming intrinsic n-type doping from the SiC substrate, resulting in p-type functionality. A smooth transition from n- to p-type carriers, spanning a Fermi shift of 0.45 eV, is observed by controlling the density and chemical composition of HSQ. This technique provides a route for complementary transistor and interconnect fabrication, as well as facilitating chemically doped p-n junctions in EG.
Parallel programming in Java: pre-conference workshop (2007)

With the ever-growing demand for solving larger computational problems in all areas of science and engineering, and with the advent of multicore-CPU desktop computers which require parallel programming techniques to obtain full performance from the hardware, it is becoming imperative to teach parallel programming to all computer science students. Since more and more students are learning Java as their principal programming language, it is becoming imperative to teach parallel programming in Java to all computer science students. However, most parallel programming textbooks are written using the non object-oriented OpenMP or MPI libraries and using the C or Fortran languages, not Java. Parallel Java (PJ), a library for parallel programming in 100% Java, was developed in response to these trends. Including capabilities patterned after the OpenMP and MPI standards, PJ is a unified API for writing object oriented parallel programs that run on shared memory multiprocessor (SMP) machines such as multicore PCs, on cluster parallel computers, and on hybrid SMP cluster parallel computers. In this workshop you'll get an introduction to parallel computing, get an introduction to PJ, write small parallel programs using PJ, run your programs on shared memory and cluster parallel computers, and measure your programs' performance. You'll also receive an advance draft copy of a new textbook the presenter is writing on parallel programming in Java.
The Mitogen-Activated Protein Kinase p38-2 Is Necessary for the Inhibition of N-Type Calcium Current by Bradykinin (1998)

Calcium influx via voltage-dependent calcium channels (ICa,V) links depolarization of excitable cells to critical cellular processes, such as secretion, contraction, and gene transcription. Fast regulation of ICa,V (<1 sec) by G-protein-coupled receptors is a relatively well-defined mechanism, whereas slow (30-60 sec) actions of transmitters and hormones on the same current remain poorly understood. In NG108-15 cells, the kinetically slow inhibition of N-type ICa,V by bradykinin (BK) requires the sequential activation of two G-proteins, heterotrimeric G13 and monomeric Rac1/Cdc42. We have now defined a role in this pathway for the relatively fast-acting p38 mitogen-activated protein kinase (MAPK). The slow inhibition of ICa,V by BK was suppressed specifically by SB203580, a compound that inhibits the p38 family of MAPKs. BK potently and selectively activated a newly discovered p38 family member, p38-2. These data provide the first evidence that a MAPK is involved in the regulation of ICa,V by a receptor-mediated process.
A short and efficient synthesis of (3S,4S)-4-[(tert-Butyloxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid ethyl ester (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA short and efficient synthesis of (3S,4S)-4-[(tert-Butyloxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid ethyl esterPaul Francis Schuda, William J. Greenlee, P. K. Chakravarty, and Philip EskolaCite this: J. Org. Chem. 1988, 53, 4, 873–875Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/jo00239a036https://doi.org/10.1021/jo00239a036research-articleACS PublicationsRequest reuse permissionsArticle Views450Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
506: Restoration of Innervated Urinary Sphincter Function Using Muscle Precursor Cells (2004)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 1:00 - 5:00 pm1 Apr 2004506: Restoration of Innervated Urinary Sphincter Function Using Muscle Precursor Cells Rene Yiou, James J. Yoo, and Anthony Atala Rene YiouRene Yiou More articles by this author , James J. YooJames J. Yoo More articles by this author , and Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37768-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "506: Restoration of Innervated Urinary Sphincter Function Using Muscle Precursor Cells." The Journal of Urology, 171(4S), p. 135 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 135 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Rene Yiou More articles by this author James J. Yoo More articles by this author Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Chemiluminescent detection of arsine oxidation (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemiluminescent detection of arsine oxidationMark E. Fraser, Donald H. Stedman, Musaddiq. Nazeeri, and Marcell. NelsonCite this: Anal. Chem. 1983, 55, 11, 1809–1810Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/ac00261a038https://doi.org/10.1021/ac00261a038research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of pulse synchronicity of an independently tunable dual-wavelength theta cavity fiber laser with an FBG array (2017)

We present a discrete tuning concept based on a theta ring cavity and an FBG array as spectral filter that enables an independently tunable dual-wavelength emission. Pulse synchronicity is analyzed based on a Time-Delay Spectrometer.
Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists (2019)

Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses. The Toll-like receptor 2 and 6 (TLR2/TLR6) agonist dipalmitoyl-<i>S</i>-glyceryl cysteine (Pam<sub>2</sub>Cys) was demonstrated as an ideal candidate for synthetic vaccine adjuvants. However, the synthesis of Pam<sub>2</sub>Cys requires expensive <i>N</i>-protected cysteine as a key reactant, which greatly limits its application as a synthetic vaccine adjuvant in large-scaled studies. Here, we report the development of N-acetylated Pam<sub>2</sub>Cys analogs as TLR2/TLR6 agonists. Instead of <i>N</i>-protected cysteine, the synthesis utilizes <i>N</i>-acetylcysteine to bring down the synthetic costs. The <i>N</i>-acetylated Pam<sub>2</sub>Cys analogs were demonstrated to activate TLR2/TLR6 in vitro. Moreover, molecular docking studies were performed to provide insights into the molecular mechanism of how N-acetylated Pam<sub>2</sub>Cys analogs bind to TLR2/TLR6. Together, these results suggest <i>N</i>-acetylated Pam<sub>2</sub>Cys analogs as inexpensive and promising synthetic vaccine adjuvants to accelerate the development of cancer vaccines in the future.
Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease (1990)

Eleven insulin-dependent diabetes mellitus (IDDM) patients with angiographically normal coronary arteries and a normal hemodynamic response to an echocardiographic-dipyridamole test and 12 normal controls were studied at rest and after atrial pacing simultaneously sampling arterial and coronary sinus blood. In IDDM patients, despite hyperglycemia [10.0 +/- 2.0 (SE) mmol/l], myocardial glucose uptake was slightly lower than in controls. This process was significantly activated in both groups during atrial pacing. The isotopically calculated net flux of lactate across myocardium, in agreement with the net balance value based on unlabeled lactate-pyruvate arteriovenous differences, showed a net uptake in controls (3.5 +/- 0.6 mumol.min-1.1.73 m-2) and a net release in IDDM (12.4 +/- 2.6; P less than 0.01). Atrial pacing stimulated lactate uptake in both groups. Myocardial uptake of ketone bodies was significantly higher in IDDM (37.0 +/- 6.3 mumol.min-1.1.73 m-2) than in controls (10.1 +/- 3.4 mumol.min-1.1.73 m-2; P less than 0.01). Free fatty acid uptake was also significantly greater in IDDM than in controls (44.1 +/- 7.0 vs. 24.1 +/- 5.1 mumol.min-1.1.73 m-2; P less than 0.01). Alanine and branched amino acids were released by diabetic but not by control hearts at rest. The normalization of blood glucose concentrations restored normal patterns of lactate and ketone body kinetics across diabetic myocardium. In conclusion, 1) at rest, myocardial lactate and amino acid uptake is markedly impaired in IDDM without coronary artery disease, and 2) the metabolic abnormalities of the diabetic myocardium are not a primary phenomenon but rather a consequence of hypoinsulinemia and hyperglycemia because insulin administration, resulting in euglycemia, restored normal patterns of cardiac metabolism.
LOKALNE PROBLEMY POWODZI ROZTOPOWYCH NA PRZYKŁADZIE ZLEWNI RZEKI BOLSZEWKI (2016)

Opracowywane w ramach wdrazania Dyrektywy Powodziowej mapy zagrozenia powodziowego nie obejmują, co wynika z przyjetej metodyki ich przygotowania, wszystkich obszarow narazonych na wystepowanie powodzi. W artykule omowiono jeden z takich przypadkow odnoszący sie do powodzi roztopowej o lokalnym zasiegu. Wykorzystując materialy archiwalne Autorzy omowili przebiegi skutki tego zjawiska , wskazując na naturalne i antropogeniczne przyczyny jego wystąpienia na przykladzie zlewni Bolszewki
Kinetic Fluorescence Optical Diffusion Tomography (2004)

We present a Bayesian, three-dimensional, parametric reconstruction method for the spatially dependent dynamics of a fluorescent contrast agent in tissue. A simulation study shows that the approach clearly distinguishes between objects with different uptake rates.
Problems: 10431-10437 (1995)

Yury J. Ionin, David M. Bloom, Daniel R. L. Brown, Kenneth R. Davidson, Jeffrey Shallit, Daniel Goffinet, Jonathan L. King, Donald A. Darling, J. Maurice Rojas, Problems: 10431-10437, The American Mathematical Monthly, Vol. 102, No. 2 (Feb., 1995), pp. 169-170
Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation (2018)

A congeneric series of 21 phosphodiesterase 2 (PDE2) inhibitors are reported. Crystal structures show how the molecules can occupy a 'top-pocket' of the active site. Molecules with small substituents do not enter the pocket, a critical leucine (Leu770) is closed and water molecules are present. Large substituents enter the pocket, opening the Leu770 conformation and displacing the waters. We also report an X-ray structure revealing a new conformation of the PDE2 active site domain. The relative binding affinities of these compounds were studied with free energy perturbation (FEP) methods and it represents an attractive real-world test case. In general, the calculations could predict the energy of small-to-small, or large-to-large molecule perturbations. However, accurately capturing the transition from small-to-large proved challenging. Only when using alternative protein conformations did results improve. The new X-ray structure, along with a modelled dimer, conferred stability to the catalytic domain during the FEP molecular dynamics (MD) simulations, increasing the convergence and thereby improving the prediction of ΔΔG of binding for some small-to-large transitions. In summary, we found the most significant improvement in results when using different protein structures, and this data set is useful for future free energy validation studies.
A dynamic model for the auroral field line plasma in the presence of field‐aligned current (1983)

We have developed a dynamic numerical model of the plasma along an auroral field line in order to provide a vehicle for studying ionosphere‐magnetosphere coupling processes. The model is a multimoment, multifluid approximation of a gyrotropic plasma consisting of three species (electrons, hydrogen ions, oxygen ions) along a segment of auroral magnetic field line extending from an altitude of 800 km to 10 earth radii. We have performed simulations for the case of a current‐free polar wind equilibrium of the field line plasma and the case in which a large upward field‐aligned current is applied to the field line. In the former case, the agreement between our model and previous static results is reasonable given the differing boundary conditions inherent in the two cases. In the case of a field‐aligned current, we note that the flux tube plasma responds to the current on several time scales. After an initial rapid heating of the electrons due to precipitation in a converging magnetic field, electric field coupling of the electrons to the ions causes thermal oscillations of the flux tube plasma to persist on time scales of the order of 1 hour, illustrating the complicated nature of the response of a collisionless plasma when heat flow transport is treated in a dynamic manner.