gebhart/patrepeval huggingface dataset:
Saturation of the hyperpolarizability of oligothiophenes (1990)

We report the observation of saturation with chain length of the second hyperpolarizability of a series of long, well-defined, conjugated oligothiophenes. This saturation occurs at the same length as that of the band gap and of the polarizability, and is attributed to a saturation of the effective conjugation length. Solvatochromic and thermochromic measurements indicate that conformational effects play a role.
The nucleoside analog clitocine is a potent and efficacious readthrough agent (2017)

Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a large number of the most common forms of cancers and are known to cause or contribute to the progression of disease. Low molecular weight compounds that induce readthrough of nonsense mutations offer a new means of treating patients with genetic disorders or cancers resulting from nonsense mutations. We have identified the nucleoside analog clitocine as a potent and efficacious suppressor of nonsense mutations. We determined that incorporation of clitocine into RNA during transcription is a prerequisite for its readthrough activity; the presence of clitocine in the third position of a premature stop codon directly induces readthrough. We demonstrate that clitocine can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. In these cells, clitocine restored production of full-length and functional p53 as evidenced by induced transcriptional activation of downstream p53 target genes, progression of cells into apoptosis, and impeded growth of nonsense-containing human ovarian cancer tumors in xenograft tumor models. Thus, clitocine induces readthrough of nonsense mutations by a previously undescribed mechanism and represents a novel therapeutic modality to treat cancers and genetic diseases caused by nonsense mutations.
A novel multi-drug metronomic chemotherapy significantly delays tumor growth in mice (2016)

The novel multi-drug daily metronomic chemotherapy evaluated in the present study was very effective in counterbalancing the immunosuppressive tumor microenvironment. Consequently, the intrinsic anti-tumor T cell immunity could exert its function, targeting specific TAA and significantly containing tumor growth. Overall, the results show that this represents a promising adjuvant approach to significantly enhance efficacy of intrinsic or vaccine-elicited tumor-specific cellular immunity.
Internet Addiction and Attention Deficit Hyperactivity Disorder Among Schoolchildren. (2015)

These findings indicate an association of ADHD, sleep disorders and internet/videogame addiction.
Multicore Fiber Fusion Splicer Suitable for Practical Applications (2022)

A compact and light weight side-view fusion splicer with core identification number recognition function of MCF is demonstrated. Average splice loss of 125 µm-4-core MCF and 183 µm-7-core MCF are successfully reduced to 0.06dB and 0.10dB.
141 MULTIVARIATE STATISTICAL ANALYSIS: AN APPROACH TO ASSESS `GALA' APPLE QUALITY. (1994)

`Gala' apples were harvested at weekly intervals for 6 weeks, refrigerated at 0C, and evaluated by a consumer panel monthly over a 6 month period for overall liking, firmness, sweetness, tartness and flavor intensities. Firmness, titratable acidity and soluble solids concentration were also measured. Initial analysis of sensory data revealed multicollinearity for overall liking, sweetness, and flavor. The five descriptors explained 75 % of the dataset variation in the first two factors. An orthogonal rotation separated overall liking, flavor and sweetness, and firmness and tartness into two independent factors. The distribution of mean scores along these independent factors showed that panelists could perceive changes due to ripening and maturation. The multivariate factor analysis was better than univariate ANOVA at illustrating how apple maturity stages were apparent to untrained panelists. Firmness was the only instrumental variable correlated to firmness ratings in the sensory tests. None of the analytical measurements could explain overall liking.
Wide area tentative scaling (WATS) for quick response in distributed cloud computing (2014)

As cloud computing is increasingly adopted by enterprises, a stringent service level agreement such as response time is required by the cloud in order to run business applications. This can be problematic because activity from geographically distributed terminals owing to globalization often increases the average response time. Federating various clouds enables to utilize datacenters in various geographical regions regardless of their servicers. The response time can be reduced by replicating the applications and related data at datacenters near the terminals by considering the factors of delay (e.g., data synchronization, distribution of multi-tier applications, and influence of other applications). However, it is unrealistic to accurately analyze all of the factors without any errors. We propose wide area tentative scaling (WATS) to improve the response time in a phased manner by repetitively replicate a part of the application and related data at other datacenters and selecting a better organization. The WATS approach is to repetitively change the organization to reduce the response time even if the analysis is incorrect, unlike mathematical-formulae-based approaches that require precise analysis. The drawback of this approach is that it consumes more computing resources due to repeating the replication. We therefore, applied Bayesian inference to search for a better organization with fewer trials. Evaluation results showed that WATS successfully reduced the response time in a phased manner.
A Particle Filtering Based Approach for Gear Prognostics (2012)

In this chapter, a particle filtering based gear prognostics method using a one-dimensional health index for spiral bevel gear subject to pitting failure mode is presented. The presented method effectively addresses the issues in applying particle filtering to mechanical component remaining useful life (RUL) prognostics by integrating a couple of new components into particle filtering: (1) data mining based techniques to effectively define the degradation state transition and measurement functions using a one-dimensional health index obtained by a whitening transform; and (2) an unbiased l-step ahead RUL estimator updated with measurement errors. The presented prognostics method is validated using data from a spiral bevel gear case study.
Anti-Endotoxin Agents. 3. Rapid Identification of High-Affinity Lipopolysaccharide-Binding Compounds in a Substituted Polyamine Library (2005)

Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are an integral part of the outer leaflet of the outer-membrane of Gram-negative bacteria. Lipopolysaccharides play a pivotal role in the pathogenesis of 'Septic Shock', a major cause of mortality in the critically ill patient, worldwide. The sequestration of circulatory endotoxin may be a viable therapeutic strategy for the prophylaxis and treatment of Gram-negative sepsis. We have earlier shown that the pharmacophore necessary for small molecules to bind LPS involves two protonatable cationic functions separated by about 15 A, permitting the simultaneous interaction with the negatively charged phosphates on lipid A, the toxically active center of endotoxin. In this report, screening of a multi-thousand membered polyamine library through the combined use of computational and bioassay-guided screens resulted in the discovery of two novel classes of LPS-binding agents. These are represented by the 1) spermine sulfonamides and 2) C-aryl-substituted spermine analogs. We present the selection approach, screening results, computational multivariate analyses and initial structure-activity relationship evaluation herein.
Ultrafast dynamics of photoexcitations in 2D Ti3C2Tz, Mo2Ti2C3Tz, and Nb2CTz MXenes (2023)

MXenes are a new class of intrinsically metallic 2D materials. Their wide range of optoelectronic properties they demonstrate as a function of their chemical composition suggest applications in electronic and photonic devices. In this work we present a comprehensive study of the optical properties of three members of the MXene family, Ti<sub>3</sub>C<sub>2</sub>T<sub>z</sub>, Mo<sub>2</sub>Ti<sub>2</sub>C<sub>3</sub>T<sub>z</sub>, and Nb<sub>2</sub>CT<sub>z</sub>, using ultrafast transient optical absorption and THz spectroscopy. We find that those properties result from a complicated interaction between free carriers, interband transitions and localized surface plasmon resonances. Elucidating the nature of photoexcitation and dynamics of carriers in these emergent materials will lay the foundation for their potential for optoelectronic applications.
Integrated devices for active plasmonics and surface enhanced Raman scattering (2011)

Nanophotonic waveguides based on surface plasmons have experienced a rapid development in terms of their design, fabrication and understanding of their plasmonic properties. For eventual applications it will be crucial to efficiently interface these waveguides with fast electronics. Therefore, we have looked both into an efficient detection and generation of surface plasmons in deep-subwavelength plasmon waveguides. We have based this work on metal-dielectric-metal (MDM) waveguides, as these waveguides have been extensively investigated before and show promising properties in terms of field confinement and propagation lengths. We have coupled these waveguides to both integrated detectors and light-emitting diodes, resulting in scalable and potentially very fast transducers between the electronic and plasmonic domain. Moreover, we are currently working on active sources to generate coherent surface plasmons in these highly confined waveguides.
Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A- selective adrenoceptor antagonist (2002)

The convergent synthesis of a potent α 1A -selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4'-dipyridyl.Key words: dihydropyrimidinone, enzymatic resolution, palladium coupling.
Multi-tone signaling for high-speed backplane electrical links (2005)

A multi-tone architecture is proposed for high-speed backplane serial links. To limit complexity, the links use analog multi-tone rather than the more modern DMT. The tradeoffs involved in the design of such a system are examined and the performance of a serial link based on this approach is compared to a baseband architecture in terms of data rate and complexity using a convex optimization framework. Slightly less than 2/spl times/ improvement in data rate at reasonable complexity is shown to be achievable with the proposed architecture.
Electrochemical cell stack assembly (2023)

Multiple stacks of tubular electrochemical cells having a dense electrolyte disposed between an anode and a cathode preferably deposited as thin films arranged in parallel on stamped conductive interconnect sheets or ferrules. The stack allows one or more electrochemical cell to malfunction without disabling the entire stack. Stack efficiency is enhanced through simplified gas manifolding, gas recycling, reduced operating temperature and improved heat distribution.
Extracting biological meaning from global proteomic data on circulating-blood platelets: Effects of diabetes and storage time (2008)

Transfusion of platelets into patients suffering from trauma and a variety of disease is a common medical practice that involves millions of units per year. Partial activation of platelets can result in the release of bioactive proteins and lipid mediators that increase the risk of adverse post-transfusion effects. Type-2 diabetes and storage are two factors known to cause partial activation of platelets. A global proteomic study was undertaken to investigate these effects. In this paper we discuss the methods used to interpret these data in terms of biological processes affected by diabetes and storage. The main emphasis is on the processing of proteomic data for gene ontology enrichment analysis by techniques originally designed for microarray data.
Supplementary Methods from <i>In Vivo</i> Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution (2023)

&lt;p&gt;PDF file, 118KB, Histology and Image processing information.&lt;/p&gt;
Supplementary Tables 1 to 3 and Supplementary Figures 1 to 7 from Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2 (2023)

&lt;p&gt;PDF - 128K, Supplemental Table 1: Clinical and molecular characteristics of cell lines; Supplemental Table 2: Sequences of primers used for Q-RT-PCR and CHIP; Supplemental Table 3: Targeting sequences of shRNA constructs; Supplemental Figure S1: JQ1 inhibits STAT5-dependent gene expression; Supplemental Figure S2: JQ1 inhibits expression of endogenous STAT5 target genes; Supplemental Figure S3: RNA interference constructs targeting bromodomain proteins show specificity; Supplemental Figure S4: Among bromodomain proteins, only inhibition of Brd2 reduces STAT5 transcriptional function; Supplemental Figure S5: Brd2 depletion reduces expression of STAT5 target genes only in cells with constitutively active STAT5. shRNA to Brd2 or GFP (as a control) was introduced into cells with (A) or without (B) activated STAT5, and quantitative RT-PCR analysis was performed for the indicated genes; Supplemental Figure S6: A. JQ1 reduces viability of T lymphocytic leukemia cells. B. JQ1 reduces Myc protein expression in T-ALL; Supplemental Figure S7. A. JQ1 has minimal effects on the viability of mononuclear cells from human cord blood. B. Kinase inhibitors have minimal effects on the viability of mononuclear cells from human cord blood.&lt;/p&gt;
Mutation in human CLPX elevates levels of δ- aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria (2017)

Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyrias, eight forms of which have been described. The genetic penetrance of the porphyrias is clinically variable, underscoring the role of additional causative, contributing, and modifier genes. We previously discovered that the mitochondrial AAA+ unfoldase ClpX promotes heme biosynthesis by activation of δ-aminolevulinate synthase (ALAS), which catalyzes the first step of heme synthesis. CLPX has also been reported to mediate heme-induced turnover of ALAS. Here we report a dominant mutation in the ATPase active site of human CLPX, p.Gly298Asp, that results in pathological accumulation of the heme biosynthesis intermediate protoporphyrin IX (PPIX). Amassing of PPIX in erythroid cells promotes erythropoietic protoporphyria (EPP) in the affected family. The mutation in <i>CLPX</i> inactivates its ATPase activity, resulting in coassembly of mutant and WT protomers to form an enzyme with reduced activity. The presence of low-activity CLPX increases the posttranslational stability of ALAS, causing increased ALAS protein and ALA levels, leading to abnormal accumulation of PPIX. Our results thus identify an additional molecular mechanism underlying the development of EPP and further our understanding of the multiple mechanisms by which CLPX controls heme metabolism.
Sir John Did His Duty [Book Review] (1983)

Publishing details for: Garfield Barwick, Sir John Did His Duty, Serendip Publications, Sydney, 1983 pp. i-xi, 1-129 p., ISBN 094937900X. Includes footnotes.
Multivariate Statistical Analysis of Orthogonal Mass Spectral Data for the Identification of Chemical Attribution Signatures of 3-Methylfentanyl (2016)

Critical to many modern forensic investigations is the chemical attribution of the origin of an illegal drug. This process greatly relies on identification of compounds indicative of its clandestine or commercial production. The results of these studies can yield detailed information on method of manufacture, sophistication of the synthesis operation, starting material source, and final product. In the present work, chemical attribution signatures (CAS) associated with the synthesis of the analgesic 3- methylfentanyl, N-(3-methyl-1-phenethylpiperidin-4-yl)-N-phenylpropanamide, were investigated. Six synthesis methods were studied in an effort to identify and classify route-specific signatures. These methods were chosen to minimize the use of scheduled precursors, complicated laboratory equipment, number of overall steps, and demanding reaction conditions. Using gas and liquid chromatographies combined with mass spectrometric methods (GC-QTOF and LC-QTOF) in conjunction with inductivelycoupled plasma mass spectrometry (ICP-MS), over 240 distinct compounds and elements were monitored. As seen in our previous work with CAS of fentanyl synthesis the complexity of the resultant data matrix necessitated the use of multivariate statistical analysis. Using partial least squares discriminant analysis (PLS-DA), 62 statistically significant, route-specific CAS were identified. Statistical classification models using a variety of machine learning techniques were then developed with the ability to predict the method of 3-methylfentanyl synthesis from three blind crude samples generated by synthetic chemists without prior experience with these methods.
Power Allocation Algorithms for ZF-THP Sum Rate Optimization in Multi-user Multi-antenna Systems (2012)

이 논문에서 우리는 Tomlinson-Harashima precoding (THP)를 이용한 다중 입력 단일 출력 다중 사용자 하향링크 시스템을 위한 전력할당 기법에 대해 알아본다. Zero-forcing THP 시스템의 sum rate를 최대화하기 위해 우리는 이전 방법과는 달리 mutual information 방법을 적용하였다. 나아가서, 모듈로 오퍼레이션을 사용하는 유저에 적절한 전력 레벨을 할당하기 위해 간단한 전력 할당 알고리즘을 제안한다. 실험 결과는 제안된 기법이 기존의 water-filling 기법보다 성능이 우수하고, 시스템의 최적의 성능을 내는 기법과 성능은 유사하면서 보다 작은 복잡도로 이루는 것을 보여준다. In this paper, we study a power allocation technique for Tomlinson-Harashima precoding (THP) in multi-user multiple input single output (MISO) downlink systems. In contrast to previous approaches, a mutual information based method is exploited for maximizing the sum rate of zero-forcing THP systems. Then, we propose a simple power allocation algorithm which assigns proper power level for modulo operated users. Simulation results show that the proposed scheme outperforms a conventional water-filling method, and it provides similar performance with near optimal method with much reduced complexity.
Effects of Ultrasound and Microwaves on Selective Reduction: Catalyst Preparation and Reactions (2014)

Abstract The reduction of organic compounds through catalytic hydrogenation is an important transformation in organic chemistry, especially in the synthesis of fine chemicals, natural products, and pharmaceuticals. This review mainly focuses on the selective reduction of substrates with multiple functional groups. Literature from the last two decades has proved the pivotal role that ultrasound and microwaves can play not only in the preparation of environmentally friendly, efficient catalysts but also in their use in catalytic reactions. Owing to the specific selective activation of the solid catalyst surface, dielectric heating and acoustic cavitation may dramatically enhance the reaction rate and selectivity. A thorough literature survey was the first step in the MAPSYN project (EU 7th Framework Program) and has the goal of the industrial demonstration of selective hydrogenations intensified by microwaves and ultrasound. Both techniques are irreplaceable tools in heterogeneous catalysis and can be expected to bring even greater success in the near future as processes are scaled up with suitable flow reactors equipped with on‐line analytical monitoring.
Building Hardened Internet-of-Things Clients with Language-Theoretic Security (2017)

Unprincipled input handling has caused many of the most prevalent and severe vulnerabilities in the Internet era, and this trend appears to continue in the emerging Internet of Things (IoT). In this paper, we present a methodology to build secure input-handling functionality for application-layer IoT protocols by applying the Language-theoretic Security (LangSec) philosophy. We have built working implementations for the XMPP and MQTT protocols and demonstrated that our clients, which consist of less than a hundred lines of code, correctly recognize all valid messages in our tests. With respect to CPU time, our clients compare well against the most widely deployed implementations of these two protocols.
Influence of Test Conditions on Tribological Behavior (2005)

A series of cooperative interlaboratory tests (RR, round robins) was conducted annuallly from 1997 to 2005 by the DIN 51834 Working Group on Tribological Tests using a Translatory Oscillation Apparatus (SRV™®) in cooperation with ASTM D02. The statistical analysis of these test results shows the influence of cleaning solvent and seizure criteria on the tribological properties regarding O.K.-load of the lubricants tested. Coefficients of friction and wear results are ranked according to the effects of ten different cleaning solvents, where isopropanol gave the lowest values and isoparaffin solvents the highest. The wear volume is more descriptive than the wear scar diameter. The effect of machine model on coefficients of friction varied from about 0.2% to 0.9% of mean. Wear results were not affected. The load step interval of 1, 3 or 6 minutes influences the pass load of solid bonded films.
Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. (1992)

We inoculated rabbits with synthetic phosphopeptides, duplicating a major autophosphorylation site of the c-erbB-2 protooncogene product. The rabbits produced antisera that, after reverse immunoaffinity purification, selectively recognize the erbB-2 protein in its enzymatically active configuration. These anti-phosphopeptide antisera identify a subset of erbB-2-positive human cell lines wherein the protein is constitutively active as a tyrosine kinase. Synthetic phosphopeptides incorporating informative protein phosphorylation sites may prove useful for generating antibodies that indicate the activation state of additional tyrosine kinases and perhaps other proteins phosphorylated on serine and threonine residues.
Interference management with partial uplink/downlink spectrum overlap (2016)

Simultaneous reuse of spectral resources by uplink and downlink, denoted as in-band full duplex (FD) communication, is promoted to double the spectral efficiency when compared to its half-duplex (HD) counterpart. Interference management, however, remains challenging in FD cellular networks, especially when high disparity between uplink and downlink transmission powers exists. The uplink performance can be particularly deteriorated when operating on channels that are simultaneously occupied with downlink transmission. This paper considers a cellular wireless system with partial spectrum overlap between the downlink and uplink. The performance of the system becomes, therefore, a function of the overlap fraction, as well as the power levels of both the uplink and downlink transmissions. The paper considers the problem of maximizing an overall network utility to find the uplink/downlink transmission powers and the spectrum overlap fraction between the uplink and downlink spectrum in each cell, and proposes solving the problem using interior point method. Simulations results confirm the vulnerability of the uplink performance to the FD operation, and show the superiority of the proposed scheme over the FD and HD schemes. The results further show that explicit uplink and downlink performance should be considered for efficient design of cellular networks with overlapping uplink/downlink resources.