gebhart/patrepeval huggingface dataset:
Adaptive Encoders: The New Generation of MPEG-2 Encoders (2000)

Whereas current debate concerns more object-oriented technologies, such as the MPEG-4 standardization process, this paper adresses the state of the art of MPEG-2 technology. The MPEG-2 standard was adopted four years ago and is currently used for broadcasting digital television worldwide. Some comments and requirements from the first field trials require a new generation of MPEG-2 compression systems, and it was the objective of this paper to try to give some inputs for them. Whereas the first generations were mainly an optimization of the TM5 model with new motion estimators, new bit-rate control strategies and sometimes new mode selection algorithms, this new generation will be adaptive to the picture content and complexity. This adaptation concerns not only the input data (such as picture resolution, noise reduction) or the encoder itself (GOP structure, local adaptation, multipass encoding), but also the bandwidth (statistical multiplexing). From the results presented here, a 20 to 30% bit savings can be expected on average, and locally more than 50% (for special cases where the encoders fails, i.e,. noise, scene cuts, fading). After being in the cost and system software, the competition is now clearly on compression efficiency to add as many programs as possible into one single channel. The new techniques developed and introduced in this phase of optimization will certainly be exploited in future standards such as MPEG-4 or MPEG-7 where segmentation and scene characterization, respectively, will be key technologies.
Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5. (1987)

We have investigated the mechanism of action of IL 1 on T cell activation. For this purpose, we analyzed the content of specific messenger RNA for lymphokines and other genes that are associated with T cell activation in the murine IL 1-dependent T cell lymphoma LBRM33-1A5. Using cloned genes for IL 2, IL 3, TGF-beta, TY5, IL 2 receptor, Ly-1, c-myc, and p53 as probes in the S1 nuclease protection assay, we compared the amount of specific transcripts among total RNA prepared from unstimulated cells, IL 1 alpha or PHA-stimulated cells, and PHA plus IL 1 alpha-stimulated cells. IL 1 alpha augmented the PHA-induced accumulation of IL 2 mRNA with a magnitude comparable to the amount of IL 2 produced, suggesting that IL 1 alpha modulates IL 2 gene expression at the RNA level. Similar results were obtained with IL 3. We also observed that Ly-1 mRNA appears after PHA treatment and its accumulation was augmented by IL 1 alpha addition. On the basis of the effects of IL 1 alpha and/or PHA treatments on gene expression, we classified these genes into four groups. In all cases, IL 1 alpha seemed to affect mRNA levels quantitatively. These observations support previously described characteristics of this cytokine as a co-stimulator of T cell activation.
Microglial priming through the lung-brain axis: the role of air pollution-induced circulating factors (2016)

Air pollution is implicated in neurodegenerative disease risk and progression and in microglial activation, but the mechanisms are unknown. In this study, microglia remained activated 24 h after ozone (O3) exposure in rats, suggesting a persistent signal from lung to brain. Ex vivo analysis of serum from O3-treated rats revealed an augmented microglial proinflammatory response and β-amyloid 42 (Aβ42) neurotoxicity independent of traditional circulating cytokines, where macrophage-1 antigen-mediated microglia proinflammatory priming. Aged mice exhibited reduced pulmonary immune profiles and the most pronounced neuroinflammation and microglial activation in response to mixed vehicle emissions. Consistent with this premise, cluster of differentiation 36 (CD36)(-/-) mice exhibited impaired pulmonary immune responses concurrent with augmented neuroinflammation and microglial activation in response to O3 Further, aging glia were more sensitive to the proinflammatory effects of O3 serum. Together, these findings outline the lung-brain axis, where air pollutant exposures result in circulating, cytokine-independent signals present in serum that elevate the brain proinflammatory milieu, which is linked to the pulmonary response and is further augmented with age.-Mumaw, C. L., Levesque, S., McGraw, C., Robertson, S., Lucas, S., Stafflinger, J. E., Campen, M. J., Hall, P., Norenberg, J. P., Anderson, T., Lund, A. K., McDonald, J. D., Ottens, A. K., Block, M. L. Microglial priming through the lung-brain axis: the role of air pollution-induced circulating factors.
Experimental Results of Hybrid and Refractive Achromatic Doublets Made of PC and PMMA (2012)

To combine achromatic system with cost-effective technology, we propose the use or hybride (refractive/diffractive) and refractive doublets Fresnel lenses. These two technologies have been compared experimentally from an optical point of view.
A systematic analysis of intronic sequences downstream of 5′ splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation (2008)

To identify human intronic sequences associated with 5' splice site recognition, we performed a systematic search for motifs enriched in introns downstream of both constitutive and alternative cassette exons. Significant enrichment was observed for U-rich motifs within 100 nucleotides downstream of 5' splice sites of both classes of exons, with the highest enrichment between positions +6 and +30. Exons adjacent to U-rich intronic motifs contain lower frequencies of exonic splicing enhancers and higher frequencies of exonic splicing silencers, compared with exons not followed by U-rich intronic motifs. These findings motivated us to explore the possibility of a widespread role for U-rich motifs in promoting exon inclusion. Since cytotoxic granule-associated RNA binding protein (TIA1) and TIA1-like 1 (TIAL1; also known as TIAR) were previously shown in vitro to bind to U-rich motifs downstream of 5' splice sites, and to facilitate 5' splice site recognition in vitro and in vivo, we investigated whether these factors function more generally in the regulation of splicing of exons followed by U-rich intronic motifs. Simultaneous knockdown of TIA1 and TIAL1 resulted in increased skipping of 36/41 (88%) of alternatively spliced exons associated with U-rich motifs, but did not affect 32/33 (97%) alternatively spliced exons that are not associated with U-rich motifs. The increase in exon skipping correlated with the proximity of the first U-rich motif and the overall "U-richness" of the adjacent intronic region. The majority of the alternative splicing events regulated by TIA1/TIAL1 are conserved in mouse, and the corresponding genes are associated with diverse cellular functions. Based on our results, we estimate that approximately 15% of alternative cassette exons are regulated by TIA1/TIAL1 via U-rich intronic elements.
Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii (1995)

Pyrophosphate-dependent phosphofructokinase (PPi-PFK) was identified previously in Toxoplasma gondii as the only kinase that phosphorylates fructose-6-P to fructose-1,6-bisP. Since such an enzyme is not present in mammals, it was considered to be a good target for prospective selective inhibitors of the parasite. We have examined the effects of several phosphonic acid derivatives, analogs of pyrophosphate, on PPi-PFK activity, as well as on the replication of T. gondii in human foreskin fibroblast (HFF) cells. The most active compound in inhibiting PPi-PFK was tetrasodium carbonyldiphosphonate. Several bisphosphonates and related arylhydrazones showed inhibition of the enzyme, but with higher IC50 values. Although several phosphonoacetic acid derivatives also inhibited PPi-PFK, as a group they were less potent than the bisphosphonate derivatives. Comparison among the structures of various inhibitors and their effects against PPi-PFK indicates that a carbonyl (C=O) or amino (C=N) group between two phosphoryl moieties is associated with more potent enzyme inhibiton. Tetrasodium carbonyldiphosphonate did not show a significant effect against replication of T. gondii cells, probably because, as a charged molecule, it could not cross the cell membrane to reach the intracellular parasite. Tetraisopropyl carbonyldiphosphonate 2,4-dinitrophenylhydrazone showed some selective inhibitory effect against replication of the parasite in the HFF cells and protected the mammalian cells from damage by T. gondii. The results indicate that carbonyldiphosphonic acid is a good prototype compound that is amenable to chemical manipulation, which, in turn, may optimize selective inhibition of T. gondii PPi-PFK and increase accessibility to the intracellular parasite.
STUDY OF NANOPOROUS MEMBRANES WITH APPLICATIONS IN THE ENHANCED DETECTION OF CADIOVASCULAR BIOMARKER PROTEINS (2010)

The goal of this work is to understand the role of nanoconfinement in designing molecular biosensors. We have been investigating microdevices incorporated with nanoporous membranes as molecular biosensor platforms. Detection of ultra low concentration of biomolecules is the key expectation from the new class of molecular biosensors utilizing nanomaterial. In this paper we have evaluated the role of the physical attributes of nanoporous aluminum oxide membranes in nanoconfinement and enhancing sensitivity of detection of protein biomolecules. In this biosensor configuration we have generated a sandwich assay in a high density array of nanoscale confined spaces generated by overlaying the nanoporous alumina membrane over metallic microscale sensing sites. The binding of the biomolecules results in the perturbation of the electrical double layer due to the binding of the test protein (C-reactive protein). Using electrical impedance spectroscopy (EIS), the capacitance changes in the electrical double layer associated with specific protein binding has been evaluated. The sensor performance metrics of sensitivity and dynamic range have been analyzed with changes in the pore diameter.
Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer (2017)

Genomic alterations involving translocations of the ETS-related gene ERG occur in approximately half of prostate cancer cases. These alterations result in aberrant, androgen-regulated production of ERG protein variants that directly contribute to disease development and progression. This study describes the discovery and characterization of a new class of small molecule ERG antagonists identified through rational in silico methods. These antagonists are designed to sterically block DNA binding by the ETS domain of ERG and thereby disrupt transcriptional activity. We confirmed the direct binding of a lead compound, VPC-18005, with the ERG-ETS domain using biophysical approaches. We then demonstrated VPC-18005 reduced migration and invasion rates of ERG expressing prostate cancer cells, and reduced metastasis in a zebrafish xenograft model. These results demonstrate proof-of-principal that small molecule targeting of the ERG-ETS domain can suppress transcriptional activity and reverse transformed characteristics of prostate cancers aberrantly expressing ERG. Clinical advancement of the developed small molecule inhibitors may provide new therapeutic agents for use as alternatives to, or in combination with, current therapies for men with ERG-expressing metastatic castration-resistant prostate cancer.
Preparation and Permeation Properties of a pH-Responsive Polyacrylic Acid Coated Porous Alumina Membrane (2023)

A pH-responsive membrane is expected to be used for applications such as drug delivery, controlling chemical release, bioprocessing, and water treatment. Polyacrylic acid (PAA) is a pH-responsive polymer that swells at high pH. A tubular α-alumina porous support was coated with PAA by grafting to introduce appropriate functional groups, followed by polymerization with acrylic acid. The permeances of acetic acid, lactic acid, phenol, and caffeine were evaluated by circulating water inside the membrane, measuring the concentration of species that permeated into the water, and analyzing the results with the permeation model. The permeance of all species decreased with increasing pH, and that of phenol was the largest among these species. At high pH, the PAA carboxy group in the membrane dissociated into carboxy ions and protons, causing the swelling of PAA due to electrical repulsion between the negative charges of the PAA chain, which decreased the pore size of the membrane and suppressed permeation. Furthermore, the electrical repulsion between negatively charged species and the PAA membrane also suppressed the permeation. The results of this study demonstrated that the PAA-coated α-alumina porous support functioned as a pH-responsive membrane.
Supplementary Materials & Methods from YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis (2023)

&lt;p&gt;Supplementary Materials &amp; Methods&lt;/p&gt;
UAS Remote ID (2020)

This document is an Applicability Statement for various IETF Technical
Specifications, including the Host Identity Protocol (HIPv2) and the
Domain Name System (DNS), complementing emerging external standards
for Unmanned Aircraft System (UAS) remote identification (RID). The
objectives are: to facilitate use of existing Internet services to
support UAS RID and to enable enhanced RID related services; and to
enable verification that UAS RID information is trustworthy (to some
extent, even in the absence of Internet connectivity at the receiving
node).
Use of oral diabetes medications and the risk of incident dementia in US veterans aged ≥60 years with type 2 diabetes (2022)

Among patients with T2D, TZD use was associated with a lower risk of dementia, and SU use was associated with a higher risk compared with MET use. Supplementing SU with either MET or TZD may partially offset its prodementia effects. These findings may help inform medication selection for elderly patients with T2D at high risk of dementia.
Heat-assisted magnetic probe recording on a granular CoNi/Pt multilayered film (2006)

A method of heat-assisted magnetic recording potentially suitable for probe-based storage systems is characterized. Field emission current from a scanning tunnelling microscope tip is used as the heating source. Pulse voltages of 5 V were applied to a granular CoNi/Pt multilayered film. Experimental results show that an average mark size of 90–120 nm was achieved with the minimum of 70 nm. A model of dynamic domain formation is built to quantitatively explain the experimental results. It agrees with experiments. Based on this model, we will be able to figure out the proposals to achieve small marks for ultra-high recording density.
3D Framework Structure of a New Lithium Thiophosphate, LiTi2(PS4)3, as Lithium Insertion Hosts (2007)

The M2(PS4)3 (M = transition metal) structure has been investigated as a new open 3D-framework structure for electrode materials for lithium rechargeable batteries. One of these compounds, LiTi2(PS4)3, was synthesized from solid state reaction. From the single crystal X-ray diffraction analysis, it was observed that the LiTi2(PS4)3 crystallizes in the hexagonal space group P6cc (No. 184) with a = 19.8978 (4) Å, c = 11.5198(3) Å, and Z = 8. The resemblance of the powder X-ray diffraction pattern and the lattice parameters obtained from single crystal X-ray diffraction measurement indicates that the crystal structure is isomorphous with NaTi2(PS4)3. This structure is built of TiS6 octahedra linked by edges to PS4 tetrahedra and vice versa to build a 3D framework. Most attractively, very wide tunnels are obtained along the c-axis where lithium ions are mobile. Electrochemical insertion of lithium into LiTi2(PS4)3 was carried out. The initial structure of LiTi2(PS4)3 was changed with initial insertion of lithium, but ∼7 Li per formula unit could be inserted in the modified structure without decomposition of the starting material. However, such a large capacity was not retained on cycling.
Multi-resonant acoustic-wave-lumped-element resonators (AWLRs) for multi-band bandpass filters with enhanced fractional bandwidth (2017)

This paper reports on the design of multi-band acoustic-wave-resonator-(AWR)-based bandpass filters (BPFs) with enhanced-fractional-bandwidth (FBW) quasi-elliptic-type passbands. They are based on multi-resonant acoustic-wave-lumped-element resonators (AWLRs) that are shaped by the inparallel cascade of multiple (equal to the desired number of transmission bands) one-port-type AWRs and one lumped-element (LE) resonator. By cascading them in-series through impedance inverters, passbands with increased selectivity and enhanced FBW (i.e., larger than the electromechanical coupling coefficient kt <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) can be obtained. In addition, they preserve the high-quality-factor (Q) characteristics of the AWRs. For experimental-demonstration purposes, two UHF-band dual-band BPF prototypes with alternative levels of FBW were designed, manufactured, and measured. They exhibited two transmission bands centered at 418 MHz and 434 MHz, respectively, with FBWs of 1-3k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and minimum in-band insertion loss (IL) in the range of 0.5-1.25 dB (i.e., effective Q >10,000).
Spectroscopic Visualization of Vortex Flows Using Dye‐Containing Nanofibers (2007)

Which way around? A J-aggregated zinc porphyrin dendrimer can be used to detect the macroscopic chirality of a vortex. The sign of the circular dichroism response changes quickly upon switching from clockwise (CW) to counterclockwise (CCW) stirring (see picture). The observed chiroptical activity most likely arises from a macroscopic helical alignment of nanofibers formed from the polymeric J-aggregate.
Investigating SEM-contour to CD-SEM matching (2021)

The control and the characterization of semiconductor very fine devices on a wafer are commonly performed by mean of a scanning electron microscope (SEM) to derive a critical dimension (CD) from a pair of parallel edges extracted from the images. However, this approach is often not very reliable when dealing with complex 2D patterns. An alternative is to use SEM contour technique to extract all the edges of the image. This method is more versatile and robust but before being implemented in a manufacturing environment, it must demonstrate that it can be matched well with traditional CD-SEM. Aim: The objective of this work is to present a method to evaluate and optimize the CD matching between a reference standard SEM-CD and SEM-Contours. Approach: After describing the metric used to assess the matching performance, we propose to screen some important influent parameters to give an evaluation of the best matching that we achieved with our experimental data. Results: After optimizing the matching calibration parameters and optimizing the selection of the best anchor pattern for the matching we could achieve a 3s-Total Measurement Uncertainty of 0.8 nm and 3.2 nm for 1D and 2D patterns. Conclusions: We established a method to achieve good matching performance that should facilitate the introduction of SEM contour in a manufacturing environment.
Wavefront propagation from one plane to another with the use of Zernike polynomials and Taylor monomials (2009)

In wavefront-driven vision correction, ocular aberrations are often measured on the pupil plane and the correction is applied on a different plane. The problem with this practice is that any changes undergone by the wavefront as it propagates between planes are not currently included in devising customized vision correction. With some valid approximations, we have developed an analytical foundation based on geometric optics in which Zernike polynomials are used to characterize the propagation of the wavefront from one plane to another. Both the boundary and the magnitude of the wavefront change after the propagation. Taylor monomials were used to realize the propagation because of their simple form for this purpose. The method we developed to identify changes in low-order aberrations was verified with the classical vertex correction formula. The method we developed to identify changes in high-order aberrations was verified with ZEMAX ray-tracing software. Although the method may not be valid for highly irregular wavefronts and it was only proven for wavefronts with low-order or high-order aberrations, our analysis showed that changes in the propagating wavefront are significant and should, therefore, be included in calculating vision correction. This new approach could be of major significance in calculating wavefront-driven vision correction whether by refractive surgery, contact lenses, intraocular lenses, or spectacles.
Analytical and chemometric approaches for quality characterization of Cannabis sativa L. with focus on cannabinoids (2021)

The quality characterization of Cannabis sativa L., especially with respect to its containing cannabinoids, is associated with many analytical challenges. Within this context, the power of chemometrics is recognized for interpretation and optimization of analytical procedures [1], as was undertaken in this work. Initially, Design of Experiments was employed for the optimization of extraction conditions following rational comparison of extraction techniques [2]. In parallel, effective chromatographic methods based on UPLC-PDA and GC-MS were developed for quantitative purposes and characterization of extracts. Pattern recognition techniques were then applied on HPTLC chromatograms to investigate the effect of extraction solvent on metabolite fingerprints and cannabinoid yield. Furthermore, classification and discrimination of hemp samples from different Greek regions and cultivars was attempted through chemometric processing. To this end, both first- and second-order data from LC-PDA were analyzed with multivariate techniques, also exploiting the multi-way nature of data. Finally, an NMR-based workflow was developed for metabolic profiling of C. sativa samples and identification of potential biomarker compounds.
Seeing trees but not the forest (2001)

PD may affect the patient's ability to perceive large spatial configurations. As global configurations in subjects may be perceived preferentially over local patterns, it is possible that DA depletion induces an aberrant perceptual-attentional bias, such that patients have a narrowed attentional floodlight.
Figure S7 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer (2023)

&lt;p&gt;ERCC3 interacting proteins.&lt;/p&gt;
Bearing currents and their relationship to PWM drives (1997)

This paper examines AC motor shaft voltages and the resulting bearing currents when operated under pulse width modulation (PWM) voltage source inverters. The paper reviews the mechanical and electrical characteristics of the bearings and motor in relation to shaft voltages and bearing currents. A brief review of previous work is addressed, including the system model and experimental results. The theory of electric discharge machining (EDM) is presented, including component calculations of the system elements. The effect of system elements on shaft voltages and bearing currents are evaluated experimentally and the results compared to theory. A design calculation is proposed that provides the relative potential for EDM. Finally, the paper presents quantitative results on one solution to the shaft voltage and bearing current problem.