gebhart/patrepeval huggingface dataset:
A Model for Signatories in Cyber-Physical Systems (2020)

Distributed Internet of Things and cyber-physical systems can potentially be used as agents to automatically sign events and transactions on behalf of users. To accomplish this, there is a need for a model that can represent the relationships, credentials and organizational hierarchies of people and devices, facilitating agents acting as signatories in a controlled way. This paper proposes such a model, where people in different positions are entitled to sign on behalf of organizations or departments therein and extend that to representing machines. Central in this model is the Power of Attorney (PoA), which is a self-contained and signed digital document that for a limited time and in a defined context, authorizes a particular agent (whether a person or device) to sign on behalf of a principal. Although such self-contained PoAs can be stored anywhere, we propose a conceptual architecture based on PoAs and include a signatory registry that keeps track of organizational hierarchies in terms of people and devices according to the defined model and stored PoAs in that context.
Targeting the Epigenetic Non-Coding RNA MALAT1/Wnt Signaling Axis as a Therapeutic Approach to Suppress Stemness and Metastasis in Hepatocellular Carcinoma (2020)

Background: With recorded under-performance of current standard therapeutic strategies as highlighted by high rates of post-treatment (resection or local ablation) recurrence, resistance to chemotherapy, poor overall survival, and an increasing global incidence, hepatocellular carcinoma (HCC) constitutes a medical challenge. Accumulating evidence implicates the presence of HCC stem cells (HCC-SCs) in HCC development, drug-resistance, recurrence, and progression. Therefore, treatment strategies targeting both HCC-SCs and non-CSCs are essential. Methods: Recently, there has been an increasing suggestion of MALAT1 oncogenic activity in HCC; however, its role in HCC stemness remains unexplored. Herein, we investigated the probable role of MALAT1 in the SCs-like phenotype of HCC and explored likely molecular mechanisms by which MALAT1 modulates HCC-SCs-like and metastatic phenotypes. Results: We showed that relative to normal, cirrhotic, or dysplastic liver conditions, MALAT1 was aberrantly expressed in HCC, similar to its overexpression in Huh7, Mahlavu, and SK-Hep1 HCC cells lines, compared to the normal liver cell line THLE-2. We also demonstrated a positive correlation between MALAT1 expression and poor cell differentiation status in HCC using RNAscope. Interestingly, we demonstrated that shRNA-mediated silencing of MALAT1 concomitantly downregulated the expression levels of β-catenin, Stat3, c-Myc, CK19, vimentin, and Twist1 proteins, inhibited HCC oncogenicity, and significantly suppressed the HCC-SCs-related dye-effluxing potential of HCC cells and reduced their ALDH-1 activity, partially due to inhibited MALAT1-β-catenin interaction. Additionally, using TOP/FOP (TCL/LEF-Firefly luciferase) Flash, RT-PCR, and western blot assays, we showed that silencing MALAT1 downregulates β-catenin expression, dysregulates the canonical Wnt signaling pathway, and consequently attenuates HCC tumorsphere formation efficiency, with concurrent reduction in CD133+ and CD90+ HCC cell population, and inhibits tumor growth in SK-Hep1-bearing mice. Conclusions: Taken together, our data indicate that MALAT1/Wnt is a targetable molecular candidate, and the therapeutic targeting of MALAT1/Wnt may constitute a novel promising anticancer strategy for HCC treatment.
Les animaux embarqués vivants sur les vaisseaux du voyage de découvertes aux Terres australes (2010)

http://www.editions-universite-bruxelles.be/fiche/view/2643
The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review (2011)

Several candidates presently under development look promising as P-gp inhibitors, e.g., tariquidar and elacridar. Pharmaceutical excipients currently constitute the most promising class of P-gp inhibitors and are considered safe and pharmaceutically acceptable for use in formulations. In addition, lipid-based excipients and thiolated polymers play an active role in affecting P-gp-mediated transport not only by altering the membrane fluidity or ATPase activity but by down regulating P-gp expression. An additional overture such as the prodrug derivatization of P-gp substrates is a feasible approach to bypass P-gp-mediated efflux.
How to evaluate the performance of a truck in the car to truck frontal crash (1995)

In the future a second step in the protection of car occupants in car to truck frontal crashes will include some form of energy absorption by the frontal structure of the truck. The results of recent studies into this type of crash permits to determine the most likely causes from the diversity of real life conditions, from which one or two typical situations can be brought out. More difficult is a sufficiently accurate evaluation of the situations surrounding the two vehicles involved, which is necessary when deciding upon a test speed representative of the majority of real crashes. At least, the choice in the method of testing, which should reproduce the situations of the car, its occupants and also the truck is questionable: how to obtain a method, sufficiently simple, which is representative of the complexity of the crash, will remain valid for several years and does not limit the choice in the improvement of the structures of trucks? (A) For the covering abstract of the conference see IRRD 894848.
Follicular dendritic cell (FDC)‐FcγRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development (2006)

Follicular dendritic cell (FDC)-FcgammaRIIB levels are up-regulated 1-3 days after challenge of actively immunized mice with Ag. This kinetics suggested that memory cells are not driving this response, prompting the hypothesis that immune complex (IC)-FDC interactions lead to FDC activation. To test this, mice passively immunized with anti-OVA Ab were OVA challenged to produce IC. After 3 days, levels of IC, FcgammaRIIB, ICAM-1, and VCAM-1 on FDC were analyzed. FDC were also stimulated with IC in vitro, and mRNA for FcgammaRIIB, ICAM-1, and VCAM-1 was quantified by quantitative RT-PCR. IC labeling in passively immunized WT and FcgammaRIIB-/- mice revealed five to six FDC-reticula per LN midsagittal section. In WT mice, these IC-bearing FDC-reticula corresponded with FDC-reticula labeling for FcgammaRIIB, ICAM-1, and VCAM-1. Increases in these molecules on IC-stimulated FDC were confirmed by flow cytometry. In marked contrast, in FcgammaRIIB-/- mice, no increased VCAM-1 or ICAM-1 was seen on IC-bearing FDC-reticula or on purified FDC. Addition of IC in vitro resulted in dramatic increases in mRNA for FcgammaRIIB, ICAM-1 and VCAM-1 in WT FDC, but not in FDC from FcgammaRIIB-/- mice, 2.4G2-pretreated WT FDC, B cells, or macrophages. Thus, although FDC-FcgammaRIIB was not essential for IC trapping, engagement of FDC-FcgammaRIIB with IC initiated an FDC activation pathway.
Reference Governors and Maximal Output Admissible Sets for Linear\n Periodic Systems (2018)

In this paper, we consider the problem of constraint management in Linear\nPeriodic (LP) systems using Reference Governors (RG). First, we present the\nperiodic-invariant maximal output admissible sets for LP systems. We extend the\nearlier results in the literature to Lyapunov stable LP systems with output\nconstraints, which arise in RG applications. We show that, while the invariant\nsets for these systems may not be finitely determined, a finitely-determined\ninner approximation can be obtained by constraint tightening. We further show\nthat these sets are related via simple transformations, implying that it\nsuffices to compute only one of them for real-time applications. This greatly\nreduces the memory burden of RG, at the expense of an increase in processing\nrequirements. We present a thorough analysis of this trade-off. In the second\npart of this paper, we discuss two RG formulations and discuss their\nfeasibility criteria and algorithms for their computation. Numerical\nsimulations demonstrate the efficacy of the approach.\n
Effect of Influenza Vaccination of Children on Infection Rates in Hutterite Communities (2010)

clinicaltrials.gov Identifier: NCT00877396.
Adaptive vehicle traction force control for intelligent vehicle highway systems (IVHSs) (2003)

This paper is concerned with robust longitudinal control of vehicles in intelligent vehicle highway systems by adaptive vehicle traction force control. Two different traction force controllers, adaptive fuzzy logic control and adaptive sliding-mode control, are proposed and applied to the fastest stable acceleration/deceleration and robust vehicle platooning problems. The motivation for investigating adaptive techniques arises from the unknown time-varying nature of the tire/road surface interaction that governs vehicle traction. Synchronous application of the engine or brake torques is also proposed for more stable vehicle maneuvers. The lack of controllability during braking (only one net input torque for the two control objectives, i.e., front and rear wheel slips) is partly overcome by applying auxiliary engine torque. Simulations of the two control methods are conducted using a complex nonlinear vehicle model which fully describes the dynamic behavior of the vehicle. Both controllers result in good performance under time-varying operating conditions.
Rhesus Monkey ( Macaca mulatta ) Mucosal Antimicrobial Peptides Are Close Homologues of Human Molecules (2001)

One component of host defense at mucosal surfaces appears to be epithelium-derived antimicrobial peptides. Molecules of the defensin and cathelicidin families have been studied in several species, including human and mouse. We describe in this report the identification and characterization of rhesus monkey homologues of human mucosal antimicrobial peptides. Using reverse transcriptase PCR methodology, we cloned the cDNAs of rhesus monkey beta-defensin 1 and 2 (rhBD-1 and rhBD-2) and rhesus monkey LL-37/CAP-18 (rhLL-37/rhCAP-18). The predicted amino acid sequences showed a high degree of homology to the human molecules. The expression of the monkey antimicrobial peptides was analyzed using immunohistochemistry with three polyclonal antibodies to the human molecules. As in humans, rhesus monkey antimicrobial peptides are expressed in epithelia of various organs. The present study demonstrates that beta-defensins and cathelicidins of rhesus monkeys are close homologues to the human molecules and indicate that nonhuman primates represent valid model organisms to study innate immune functions.
Studies on antigenic variability of C strains of foot‐and‐mouth disease virus by means of synthetic peptides and monoclonal antibodies (1992)

Peptides representing the sequence of the immunodominant loop of foot-and-mouth disease virus strain C-S8 (YTASARGDLAHLTTTHARHLP, residues 136-156 of VP1) and of several variant viruses have been prepared by solid phase methods. In addition, five peptides with single-residue replacements at Leu147 (Ile, Nle, Val, Ala, Gly) have been synthesized. Tosyl and dinitrophenyl protections for histidine have been compared, the latter being found to give better synthetic products. The peptides have been tested in an immunodot assay against a panel of monoclonal antibodies directed towards the VP1 loop. Immunochemical results are discussed on the basis of the mobility of the region reproduced by the peptides and the nature of the side chain of residue 147.
The Impact of Age on Skeletal Muscle Progenitor Cell Survival and Fate After Injury (2017)

Sarcopenia is defined as the loss of skeletal muscle mass and function due to age, and represents a major cause of disability in the elderly population. The contributing factors to the onset of sarcopenia are not well defined, but appear to involve age-dependent changes in both the tissue microenvironment and muscle progenitor cell (MPC) population. MPC transplantation has the potential to be a novel therapy for treatment of muscle dysfunction due to aging or injury, but has not shown significant clinical efficacy to date. The goal of this research was to use a rat model of skeletal muscle injury to examine the differential effects of age on MPC survival, differentiation, and tissue regeneration after transplantation. Fluorescently labeled MPCs, derived from young (YMPCs) and adult (AMPCs) donor rats, were transplanted in the injured tibialis anterior (TA) muscles of young, adult, and aged rats. Our results demonstrated that integration and maturation of YMPCs into mature myofibers were dependent on the age of the host microenvironment; whereas, the integration and maturation of AMPCs were less dependent on age and more dependent on intrinsic cellular changes. These data suggest that the age of both the host microenvironment and cells for transplantation must be considered when designing cell therapy regimens.
Heart rhythm characterization through induced physiological variables (2017)

Atrial fibrillation remains a major cause of morbi-mortality, making mass screening desirable and leading industry to actively develop devices devoted to automatic AF detection. Because there is a tendency toward mobile devices, there is a need for an accurate, rapid method for studying short inter-beat interval time series for real-time automatic medical monitoring. We report a new methodology to efficiently select highly discriminative variables between physiological states, here a normal sinus rhythm or atrial fibrillation. We generate induced variables using the first ten time derivatives of an RR interval time series and formally express a new multivariate metric quantifying their discriminative power to drive state variable selection. When combined with a simple classifier, this new methodology results in 99.9% classification accuracy for 1-min RR interval time series (n = 7,400), with heart rate accelerations and jerks being the most discriminant variables. We show that the RR interval time series can be drastically reduced from 60 s to 3 s, with a classification accuracy of 95.0%. We show that heart rhythm characterization is facilitated by induced variables using time derivatives, which is a generic methodology that is particularly suitable to real-time medical monitoring.
Managing Knee Osteolysis (2005)

Total knee arthroplasty has evolved into a reliable method of achieving pain relief and restoring essential knee functions. One of the current challenges is to maximize longevity of the total knee prosthesis. Bearing wear and osteolysis have emerged as signiﬁcant problems jeopardizing the longevity of contemporary designs. Engh et al. (1) suggested that the most common reason for revision of modular-type total knee arthroplasty is polyethylene wear and osteolysis. This chapter brieﬂy reviews the pathophysiology and natural history of osteolysis in total knee arthroplasty. These subjects are vital to proper diagnosis and management. The clinical presentation and work-up of patients with suspected osteolysis and polyethylene wear will be discussed. The principles of treatment are reviewed along with speciﬁc techniques necessary for surgical management. Finally, this chapter will review the results of these operative treatment methods.
An Object-Oriented Architecture for the Simulation of Rigid-Body Kinematics (1993)

Kinematic simulation involves finding simultaneous zeros for a set of functions representing mechanical linkages which constrain the positions and orientations of a set of bodies. Evaluation of these functions, and of their Jacobians with respect to the positions and orientations of the bodies, is sufficient to allow the use of a multidimensional Newton-Raphson procedure to solve the kinematic constraint equations. An abstraction comprising such a function and its Jacobian may be implemented as a virtual class in an object-oriented language, yielding a software architecture embodying benefits of object-oriented design and implementation: abstraction, encapsulation, extensibility and reusability. An implementation in Eiffel is described. » » 3 Introduction Kinematics is the study of time-independent qualities of motion, i.e. the study of motion without regard to velocities, forces or accelerations (Haug (1989)). Kinematics is the basis of the study of dynamics, which has become cen...
ChemInform Abstract: Synthesis of 4‐Amino‐8‐(2,2‐difluoro‐2‐deoxy‐β‐D‐ribofuranosyl amino)pyrimido(5,4‐d)pyrimidine (DFARPP). Stability and Cellular Cytotoxicity. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Some aspects of the syntheses of beta-lactam antibiotics and D, L-2'-epi-showdomycin (1979)

\ \,," -t Les deux compo.' uivant.ont .~.ynth'ti.'.s leoc'pheme (11).Le. deux po ldent' de haut tr'quene d' ab.orption dans l'infrarouge, 1760 CIl-l pour .1 B .t l 1790 cm-1 pour.n.Ce dernier t trop in.table pour .urvivre le temps requis pour .ttectuerle.te.ta biologique., puisqu'il d.compo en moin. 1 de trente minute., dan.le dimlthyl .u1foxide.oeuxil_ ..section La s'qenee aynth'tique menant au ~,L-2-'pi-show4omycin.(III) ,1:6 am:61ior'e, et pluieur.lnt.ermMiair ont 't' -.car.c:t'ri.'..an. ambigu!tes pour 1. p~eai.retoi..
Drug‐Drug Interaction Studies of Paliperidone and Divalproex Sodium Extended‐Release Tablets in Healthy Participants and Patients with Psychiatric Disorders (2015)

The objective of these 2 phase 1, open-label, 2-treatment, single-sequence studies was to evaluate the effect of repeated oral doses of divalproex sodium extended-release (ER) on the pharmacokinetics (PK) of a single dose of paliperidone ER in healthy participants (study 1), and the effect of multiple doses of paliperidone ER on the steady-state PK of valproic acid (VPA) in patients with psychiatric disorders (study 2), respectively. In study 1 healthy participants received, in a fixed sequential order, treatment A, paliperidone ER 12 mg (day 1); treatment B, VPA 1000 mg (2 × 500 mg divalproex sodium ER) once daily (days 5 to 18) and paliperidone ER 12 mg (day 15). In study 2 patients received treatment A, VPA (days 1-7); treatment B, VPA + paliperidone ER 12 mg (days 8-12). Divalproex sodium ER doses (study 2) were individualized such that systemic therapeutic VPA exposure from prior treatment was maintained on entry into the study. PK assessments were performed at prespecified time points (paliperidone days 1 and 15 [study 1]; VPA days 7 and 12 [study 2]). The oral bioavailability of paliperidone was increased by an estimated 51% (Cmax ) and 51%-52% (AUCs) when coadministered with divalproex sodium ER. No effect on the steady-state plasma concentration of VPA was observed following repeated coadministration with paliperidone ER: the 90%CI around the VPA exposure ratios for the 2 treatments was within the 80%-125% bioequivalence criteria for Cmax,ss and AUCτ . Both VPA and paliperidone ER were well tolerated, and no new safety concerns were identified.
Properties of the surface of silicas modified with bi-and trifunctional perfluorohexylsilanes: Adsorption of benzene (2007)

Diffuse reflection IR spectroscopy, static adsorption, and gas chromatography were used to study the chemistry and adsorption properties of the surface of silicas modified by chemically grafted bi-(C6F13(II)) and trifunctional (C6F13(III)) perfluorohexylsilanes. It was established that the modification of silica (SiO2) results in a nearly complete screening of free silanols. At the same time, IR spectra featured absorption bands belonging to weakly perturbed OH groups capable of interacting with benzene molecules. The IR spectroscopy data on benzene adsorption were found to be in close agreement with the results of static adsorption and chromatographic measurements, according to which the specific amount of benzene adsorbed decreases in the series SiO2 > C6F13(III) > C6F13(II). It was demonstrated that the heat of adsorption of benzene on the C6F13(III) sample is higher than that on the initial carrier. Grafted layers prepared from the trifunctional modifier exhibited higher efficiency in preventing benzene molecules from reaching the carrier surface.
Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis (2002)

Central to inflammatory responses are the integrin-mediated adhesive interactions of cells with their ECM-rich environment. We investigated the role of the collagen-binding integrin alpha(1)beta(1) in intestinal inflammation using the mouse model of colitis induced by dextran sodium sulfate (DSS). mAb's directed against murine alpha(1) were found to significantly attenuate inflammation and injury in DSS-treated wild-type mice; similar protection was seen in mice deficient for alpha(1)beta(1) integrin. Blockade or loss of alpha(1)beta(1) was also associated with decreased mucosal inflammatory cell infiltrate and cytokine production. Importantly, we demonstrated that development and alpha(1)-mediated inhibition of DSS-induced colitis occurred independently of lymphocytes (Rag-2(-/-) mice), and identified the monocyte as a key alpha(1)beta(1)-expressing cell type involved in the development of colitis in this model. In response to DSS, both alpha(1) deficiency and anti-alpha(1) mAb treatment significantly reduced monocyte accumulation and activation within the lamina propria. In summary, the data demonstrate that engagement of leukocyte-associated alpha(1)beta(1) receptors with ECM plays a pivotal role in mediating intestinal inflammation via promotion of monocyte movement and/or activation within the inflamed interstitium. Therapeutic strategies designed to disrupt such interactions may prove beneficial in treating intestinal inflammation.
Removal and Isolation of Germ‐Rich Fractions from Hull‐less Barley Using a Fitzpatrick Comminuting Mill and Sieves (2013)

ABSTRACT A process was developed to produce a germ‐enriched fraction from hull‐less barley using a Fitzpatrick comminuting mill (FitzMilling) followed by sieving. Hulled and hull‐less barleys contain 1.5–2.5% oil and, like wheat kernels, which contain wheat germ oil, much of the oil in barley kernels is in the germ fraction. A process that combined FitzMilling and sieving produced a germ‐enriched fraction with an oil content of ≈15% and a yield of ≈1.1%. For comparison, this is higher than the levels of oil in most samples of commercial wheat germ. Experimental conditions were also described to produce a germ‐enriched fraction with a higher yield (2.16%), but it would have lower oil content (10.24%). Germination and compositional analysis studies suggested that FitzMilling hull‐less barley for 2 min or longer reduced germination rates to 1% or less, which was interpreted to mean that almost the entire viable germ was removed. In contrast, FitzMilling conventional hulled barley for 4 min had no effect on germination, and milling for 6 and 8 min resulted in germination rates of 36 and 12%, respectively. The oil extracted from germ‐enriched fractions was rich in free phytosterols (≈1%), phytosterol esters (3–7%), and free fatty acids (2–10%). These germ‐enriched fractions and the extracted oil they contain may have value as nutraceuticals or premium edible oils.
New die-to-database mask inspection system with i-line optics for 256-Mb and 1-Gb DRAMs (1997)

For mask defect inspection in 256 Mbit and 1 Gbit DRAMs, it is necessary to have high sensitivity of 0.2 - 0.1 micrometer. A new die-to-database mask inspection system MC-2000 for 256 Mbit and 1 Gbit DRAMs has been developed. This system has high resolution optics with i-line light and high NA lens, and high speed and high accuracy data processing circuit by new multilevel bit map pattern generator, so the system has both high detectability and high throughput. This paper describes system configuration which include optical system and mechanical system, the defect inspection method, and inspection performance including defect sensitivity.