gebhart/patrepeval huggingface dataset:
A molecular complex of Ca v 1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling (2022)

Elevation of intracellular Ca2+ concentration ([Ca2+]i) activates Ca2+/calmodulin-dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is referred to as excitation–transcription (E-T) coupling. Although vascular myocytes can exhibit E-T coupling, the molecular mechanisms and physiological/pathological roles are unknown. Multiscale analysis spanning from single molecules to whole organisms has revealed essential steps in mouse vascular myocyte E-T coupling. Upon a depolarizing stimulus, Ca2+ influx through Cav1.2 voltage-dependent Ca2+ channels activates CaMKK2 and CaMK1a, resulting in intranuclear CREB phosphorylation. Within caveolae, the formation of a molecular complex of Cav1.2/CaMKK2/CaMK1a is promoted in vascular myocytes. Live imaging using a genetically encoded Ca2+ indicator revealed direct activation of CaMKK2 by Ca2+ influx through Cav1.2 localized to caveolae. CaMK1a is phosphorylated by CaMKK2 at caveolae and translocated to the nucleus upon membrane depolarization. In addition, sustained depolarization of a mesenteric artery preparation induced genes related to chemotaxis, leukocyte adhesion, and inflammation, and these changes were reversed by inhibitors of Cav1.2, CaMKK2, and CaMK, or disruption of caveolae. In the context of pathophysiology, when the mesenteric artery was loaded by high pressure in vivo, we observed CREB phosphorylation in myocytes, macrophage accumulation at adventitia, and an increase in thickness and cross-sectional area of the tunica media. These changes were reduced in caveolin1-knockout mice or in mice treated with the CaMKK2 inhibitor STO609. In summary, E-T coupling depends on Cav1.2/CaMKK2/CaMK1a localized to caveolae, and this complex converts [Ca2+]i changes into gene transcription. This ultimately leads to macrophage accumulation and media remodeling for adaptation to increased circumferential stretch.
Observation of nonclassical photon statistics in the cavity QED microlaser (2003)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. Choi, C. M. Fang-Yen, J. Lee, K. An, R. R. Dasari, and M. S. Feld, "Observation of nonclassical photon statistics in the cavity QED microlaser," in Frontiers in Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2003), paper WGG4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Molecular characterization of a granulocyte macrophage–colony-stimulating factor receptor α subunit-associated protein, GRAP (2000)

The granulocyte macrophage-colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits, alpha and beta, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. In order to explore the role of the alpha subunit in signalling, we used a yeast-2-hybrid system to identify proteins interacting with the intracellular domain of the GMR-alpha. A cDNA encoding a predicted protein of 198 amino acids, designated GRAP (GM-CSF receptor alpha subunit-associated protein), was isolated in experiments using the intracellular portion of GMR-alpha as bait. The interaction between GRAP and GMR-alpha was confirmed by coimmunoprecipitation in mammalian cells. GRAP mRNA is widely expressed in normal human and mouse tissues and in neoplastic human cell lines, but it is not restricted to cells or tissues that express GM-CSF receptors. Three discrete GRAP mRNA species were detected in human tissues and cells, with estimated sizes of 3.3, 3.1, and 1.3 kb. GRAP is highly conserved throughout evolution, and homologues are found in yeast. The GRAP locus in Saccharomyces cerevisiae was disrupted, and mutant yeast cells showed an inappropriate stress response under normal culture conditions, manifested by early accumulation of glycogen during the logarithmic growth phase. GRAP is, therefore, a highly conserved and widely expressed protein that binds to the intracellular domain of GMR-alpha, and it appears to play an important role in cellular metabolism.
Pseudogene TNXA Variants May Interfere with the Genetic Testing of CAH-X (2023)

CAH-X is a hypermobility-type Ehlers-Danlos syndrome connective tissue dysplasia affecting approximately 15% of patients with 21-hydroxylase deficiency (21-OHD) congenital adrenal hyperplasia (CAH) due to contiguous deletion of <i>CYP21A2</i> and <i>TNXB</i> genes. The two most common genetic causes of CAH-X are <i>CYP21A1P-TNXA/TNXB</i> chimeras with pseudogene <i>TNXA</i> substitution for <i>TNXB</i> exons 35-44 (CAH-X CH-1) and <i>TNXB</i> exons 40-44 (CAH-X CH-2). A total of 45 subjects (40 families) from a cohort of 278 subjects (135 families of 21-OHD and 11 families of other conditions) were found to have excessive <i>TNXB</i> exon 40 copy number as measured by digital PCR. Here, we report that 42 subjects (37 families) had at least one copy of a <i>TNXA</i> variant allele carrying a <i>TNXB</i> exon 40 sequence, whose overall allele frequency was 10.3% (48/467). Most of the <i>TNXA</i> variant alleles were in <i>cis</i> with either a normal (22/48) or an In2G (12/48) <i>CYP21A2</i> allele. There is potential interference with CAH-X molecular genetic testing based on copy number assessment, such as with digital PCR and multiplex ligation-dependent probe amplification, since this <i>TNXA</i> variant allele might mask a real copy number loss in <i>TNXB</i> exon 40. This interference most likely happens amongst genotypes of CAH-X CH-2 with an in <i>trans</i> normal or In2G <i>CYP21A2</i> allele.
On the feasibility of frequency reuse and spatial occupation in wireless device-to-device networks (2014)

Advanced, dynamic spectrum management techniques are needed for frequency reuse in tiered and heterogeneous wireless networks. For reuse of transmission resources, feasibility in a power control sense is of prime interest. In this paper, it is shown that by transforming the signal to interference and noise ratio (SINR) to a power fraction, feasibility of resource reuse can be identified. The influence of maximum transmission powers and noise on feasibility are evaluated. It is motivated that a degree of spatial occupation can be defined with power fractions and that infeasibility occurs when the overall required occupation exceeds a finite value. Based on these findings, a system model is presented that can be used to identify communication pairs for feasible resource reuse.
Withdrawn as duplicate: Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing (2021)

This article has been withdrawn due to an error that caused the article to be duplicated. The definitive version of this article is published under DOI 10.1093/neuros/nyab288.
Quantitative mapping of intracardiac blood flow in embryonic zebrafish (2003)

Using real-time in vivo imaging and digital particle image velocimetry (DPIV) we quantitatively described the intracardiac flow environment of early zebrafish (Danio rerio) embryos. Gross cardiac dynamics were defined for two embryonic stages: 4.5 days post fertilization (dpf) and 37 hours post fertilization (hpf) using high-speed transmitted light microscopy with valve dynamics visualized through high-speed laser-scanning microscopy on transgenic embryos expressing GFP.
Gas and Vapor Sorption, Permeation, and Diffusion in Glassy Amorphous Teflon AF1600 (2002)

Sorption and permeation parameters of light gases, C1−C12 hydrocarbons, and C1−C7 perfluorocarbons were determined in a random, amorphous, glassy copolymer containing 65 mol % 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole (BDD) and 35 mol % tetrafluoroethylene (TFE) (TFE/BDD65 or AF1600). AF1600 results were compared to those of another copolymer, AF2400, which contains 87 mol % BDD. As the amount of bulky, packing-disrupting BDD increases, solubility coefficients increase systematically, primarily due to increases in the nonequilibrium excess volume of the glassy polymer. Permeability and diffusivity also increase with increasing BDD content. AF1600 is easily plasticized by larger, more soluble penetrants and is susceptible to penetrant-induced conditioning. As penetrant size increases, permeability and diffusion coefficients decrease. The rates of decrease of permeability and diffusivity with increasing penetrant size, which characterize permeability and diffusivity selectivity, are intermediate between those of conventional glassy polymers and exceptionally high free volume glassy materials such as poly(1-trimethylsilyl-1-propyne) (PTMSP). Positron annihilation lifetime spectroscopy (PALS) results suggest unusually large free volume elements and a bimodal distribution of free volume element size: this is consistent with similar results obtained earlier for other high free volume glassy polymers such as AF2400 and PTMSP. Inverse gas chromatography and PALS estimates of free volume element size distributions were consistent.
Performance Limits of Energy Detection Systems with Massive Receiver Arrays (2016)

Energy detection (ED) is an attractive technique for symbol detection at receivers equipped with a large number of antennas, for example in millimeter wave communication systems. This paper investigates the performance bounds of ED with pulse amplitude modulation (PAM) in large antenna arrays under single stream transmission and fast fading assumptions. The analysis leverages information-theoretic tools and semi-numerical approach to provide bounds on the information rate, which are shown to be tight in the low and high signal-to-noise ratio (SNR) regimes, respectively. For a fixed constellation size, the impact of the number of antennas and SNR on the achievable information rate is investigated. Based on the results, heuristics are provided for the choice of the cardinality of the adaptive modulation scheme as a function of the SNR and the number of antennas.
ORASIS framework - benefits to working within the linear mixing model (2004)

The Optical Real-time Adaptive Spectral Identification System (ORASIS) continues to be developed by the Naval Research Laboratory. Recently, a new method to perform target identification based on Spectral Angle Mapper (SAM) has been demonstrated. When projected into a reduced dimension space, angles between spectra are not conserved. Proper determination of the dimensions and their coordinates of the subspace can result in maximizing the angles between a spectrum of interest and the general background. This approach can be used for target identification where the "target" can be a rare spectrum or something found in the general background. In addition, new methods to compress hyperspectral data using the ORASIS in combination with wavelets have been demonstrated. Variations on this approach continue to be worked on and will be discussed. Recent improvements to these methods as well as new directions being pursued will be discussed.
Pyridine-Carbonitrile–Carbazole-Based Delayed Fluorescence Materials with Highly Congested Structures and Excellent OLED Performance (2019)

Three pyridine-carbonitrile-carbazole-based thermally activated delayed fluorescence (TADF) materials with highly sterically congested structures have been synthesized. The donor-acceptor-type TADF emitters (26-, 246-, and 35tCzPPC) consist of a 2,6-diphenylpyridine-3,5-dicarbonitrile core (PPC) as the acceptor and a di( t-butyl)carbazole-substituted phenyl group attached to C4 of the PC core as the donor. The molecules show a unique structure containing two consecutive large twisted angles along the donor and acceptor groups. The structure leads to a nearly complete space separation of the highest occupied molecular orbital and lowest unoccupied molecular orbital, a small Δ E<sub>ST</sub> value, and excellent TADF property. Moreover, the 26- and 246tCzPPC dopants favor a horizontal alignment enhancing the light outcoupling of the device. In contrast, 35tCzPPC favors a perpendicular alignment reducing the light outcoupling efficiency of the device. The 246tCzPPC-based devices show external quantum efficiency as high as 29.6% because of excellent TADF property, very high photoluminescence quantum yield, and high Θ value in the thin films. The device performance is the best among the pyridine-carbonitrile-based TADF emitters.
Digital signal injection technique for cancellation of receive-band spurious emissions in FDD cellular transmitters (2015)

In this paper, we demonstrate a new technique for cancelling the deterministic spurious emissions from the power amplifier into the corresponding receive band in Frequency-Division Duplex (FDD) systems. Some cellular bands such as band 31 (TX: 455MHz and RX: 465MHz) have very narrow duplex spacing (only 10MHz). In these bands, power amplifier emissions due to nonlinearities are strong enough to severely desensitize the receiver even with 60–70dB transmit signal rejection in the duplexer. We have developed a fully digital technique for spurious cancellation, based on accurate modeling of PA receive band emissions, characterizing the transmitter chain in receive band, and injecting into the transmitter at baseband a cancelling signal located at the duplex spacing offset from the main transmit signal. Experimental results show receiver sensitivity improvement by more than 10dB.
Precision Measurement of $CP$ Violation in the Penguin-Mediated Decay $Bs0\phi$ (2023)

A flavor-tagged time-dependent angular analysis of the decay B_{s}^{0}→ϕϕ is performed using pp collision data collected by the LHCb experiment at the center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb^{-1}. The CP-violating phase and direct CP-violation parameter are measured to be ϕ_{s}^{ss[over ¯]s}=-0.042±0.075±0.009 rad and |λ|=1.004±0.030±0.009, respectively, assuming the same values for all polarization states of the ϕϕ system. In these results, the first uncertainties are statistical and the second systematic. These parameters are also determined separately for each polarization state, showing no evidence for polarization dependence. The results are combined with previous LHCb measurements using pp collisions at center-of-mass energies of 7 and 8 TeV, yielding ϕ_{s}^{ss[over ¯]s}=-0.074±0.069 rad and |λ|=1.009±0.030. This is the most precise study of time-dependent CP violation in a penguin-dominated B meson decay. The results are consistent with CP symmetry and with the standard model predictions.
Measuring the Modes of Optical Fibers using S2 Imaging (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. W. Nicholson, J. M. Fini, S. Ghalmi, J. C. Jasapara, A. DeSantolo, E. Monberg, and F. Dimarcello, "Measuring the Modes of Optical Fibers using S2 Imaging," in Conference on Lasers and Electro-Optics 2010, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper CWL1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Role of Quinones in Electron Transfer of PQQ–Glucose Dehydrogenase Anodes—Mediation or Orientation Effect (2015)

In this study, the influence of two quinones (1,2- and 1,4-benzoquinone) on the operation and mechanism of electron transfer in PQQ-dependent glucose dehydrogenase (PQQ-sGDH) anodes has been determined. Benzoquinones were experimentally explored as mediators present in the electrolyte. The electrochemical performance of the PQQ-sGDH anodes with and without the mediators was examined and for the first time molecular docking simulations were used to gain a fundamental understanding to explain the role of the mediator molecules in the design and operation of the enzymatic electrodes. It was proposed that the higher performance of the PQQ-sGDH anodes in the presence of 1,2- and 1,4-benzoquinones introduced in the solution is due to the shorter distance between these molecules and PQQ in the enzymatic molecule. It was also hypothesized that when 1,4-benzoquinone is adsorbed on a carbon support, it would play the dual role of a mediator and an orienting agent. At the same time, when 1,2-benzoquinone and ubiquinone are adsorbed on the electrode surface, the enzyme would transfer the electrons directly to the support, and these molecules would primarily play the role of an orienting agent.
ChemInform Abstract: Facile Synthesis of Phosphorus‐Containing Heterocycles. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Report of the International Consensus Development Conference on Female Sexual Dysfunction: Definitions and Classifications (2001)

Purpose: Female sexual dysfunction is highly prevalent but not well defined or understood. We evaluated and revised existing definitions and classifications of female sexual dysfunction.Materials a...
Statistical Analysis Plan for SEARCH Phase I: Health Outcomes among Adults (2018)

This document provides the analytic plan for evaluating adult HIV incidence, health, and implementation outcomes for the first phase of the SEARCH Study. Locked: November 27, 2017. Embargoed until July 25, 2018.
A Wirelessly Rechargeable AA Battery Using Electrodynamic Wireless Power Transmission (2021)

We report the design, fabrication, and characterization of a prototype that meets the form, fit, and function of a household 1.5 V AA battery, but which can be wirelessly recharged without removal from the host device. The prototype system comprises a low-frequency electrodynamic wireless power transmission (EWPT) receiver, a lithium polymer energy storage cell, and a power management circuit (PMC), all contained within a 3D-printed package. The EWPT receiver and overall system are experimentally characterized using a 238 Hz sinusoidal magnetic charging field and either a 1000 µF electrolytic capacitor or a lithium polymer (LiPo) cell as the storage cell. The system demonstrates a minimal operating field as low as 50 µTrms (similar in magnitude to Earth’s magnetic field). At this minimum charging field, the prototype transfers a maximum dc current of 50 µA to the capacitor, corresponding to a power delivery of 118 µW. The power effectiveness of the power management system is approximately 49%; with power effectiveness defined as the ratio between actual output power and the maximum possible power the EWPT receiver can transfer to a pure resistive load at a given field strength.
Thermoelectric Power ofp-Doped Single-Wall Carbon Nanotubes and the Role of Phonon Drag (2003)

We measured thermoelectric power S of bulk single-wall carbon nanotube materials p doped with acids. In contrast to oxygen-exposed or degassed samples, S is very small at the lowest temperatures, increases superlinearly above a characteristic and sample-dependent T, and then levels off. We attribute this unusual behavior to 1D phonon drag, in which the depression of the Fermi energy cuts off electron-phonon scattering at temperatures below a characteristic T0. This idea is supported by a model calculation in which the low temperature behavior of phonon drag is specifically related to the one-dimensional character of the electronic spectrum.
An GPU-accelerated particle tracking method for Eulerian–Lagrangian simulations using hardware ray tracing cores (2021)

To address the high computational cost of particle tracking for realistic Eulerian–Lagrangian simulations, a novel efficient and robust particle tracking method (RT method) for unstructured meshes is presented. The method, for the first time, leverages both hardware ray tracing (RT) cores and GPU parallel computing technology to accelerate Eulerian–Lagrangian simulations. The method includes a hardware-accelerated hosting cell locator using bounding volume hierarchy tree (BVH) and a robust treatment of particle-wall interaction (multiple specular reflection) using an improved neighbor searching approach. The method is implemented in a GPU-accelerated open-source code, which is verified against a reference neighbor-searching particle-tracking method (NS method) and experimental observations. To evaluate the performance of our method, several numerical simulations of fluid-driven scalar transport problem are solved. Using a verification case, we show that the particle distribution simulated by our code is in a good agreement with an experimental observation. Tracking failures and stuck particles are not observed in any simulations. Benchmark results indicate that our RT method leads to a roughly 1.8−2.0× performance improvement compared to the reference NS method for large-scale simulations (millions of mesh cells and particles).
[Ca2+]-dependent Generation of Intracellular Reactive Oxygen Species Mediates Maitotoxin-induced Cellular Responses in Human Umbilical Vein Endothelial Cells (2006)

Maitotoxin (MTX) is known as one of the most potent marine toxins involved in Ciguatera poisoning, but intracellular signaling pathways caused by MTX was not fully understood. Thus, we have investigated whether intracellular reactive oxygen species (ROS) are involved in MTX-induced cellular responses in human umbilical vein endothelial cells. MTX induced a dose-dependent increase of intracellular [Ca(2+)]. MTX stimulated the production of intracellular ROS in a dose- and time-dependent manner, which was suppressed by BAPTA-AM, an intracellular Ca(2+) che-lator. Ionomycin also elevated the ROS production in a dose-dependent manner. MTX elevated transamidation activity in a time-dependent manner and the activation was largely inhibited by transfection of tissue transglutaminase siRNA. The activation of tissue transglutaminase and ERK1/2 by MTX was sup-pressed by BAPTA-AM or ROS scavengers. In addition, MTX-induced cell death was significantly de-layed by BAPTA-AM or a ROS scavenger. These results suggest that [Ca(2+)]-dependent generation of in-tracellular ROS, at least in part, play an important role in MTX-stimulated cellular responses, such as activation of tTGase, ERK phosphorylation, and in-duction of cell death, in human umbilical vein endothelial cells.
[Inhibitory effects of LHRH on LH receptors in the rat testis]. (1978)

A single injection of LHRH to the adult male rat, as of its analog [D-Ala6, des-Gly-NH102] LHRH ethylamide, resulted in a marked decrease in LH receptors in the tests. Plasma testosterone level and the weight of the seminal vesicles and prostate were also decreased after treatment. These data demonstrate that LHRH can decrease the sensitivity of LH receptors and testicular function in the rat.
Physicsforests (2017)

PhysicsForests is a fluid-simulation framework that can simulate large scenes with several million particles in real time, including surface generation, foam, rigid-body coupling, and rendering. Instead of solving underlying Navier-Stokes equations, it predicts particle behavior approximately using machine-learning-based regression-forest method that is trained on a large set of randomly generated scenes obtained by a traditional fluid solver. The result is faster and more stable than standard methods. The simulation does not diverge even if the incompressibility constraint cannot be satisfied, for example in case of an extremely aggressive impact caused by user interaction. The parametric-input feature vector allows for simulation of a wide range of materials, differing in density, viscosity, static friction, or surface tension, and coupling of fluids with rigid bodies or with each other.