gebhart/patrepeval huggingface dataset:
Buckling of a Longitudinally Jointed Curved Composite Panel Arc Segment for Next Generation of Composite Heavy Lift Launch Vehicles: Verification Testing Analysis (2014)

In this work, an all-bonded out-of-autoclave (OoA) curved longitudinal composite joint concept, intended for use in the next generation of composite heavy lift launch vehicles, was evaluated and verified through finite element (FE) analysis, fabrication, testing, and post-test inspection. The joint was used to connect two curved, segmented, honeycomb sandwich panels representative of a Space Launch System (SLS) fairing design. The overall size of the resultant panel was 1.37 m by 0.74 m (54 in by 29 in), of which the joint comprised a 10.2 cm (4 in) wide longitudinal strip at the center. NASTRAN and ABAQUS were used to perform linear and non-linear analyses of the buckling and strength performance of the jointed panel. Geometric non-uniformities (i.e., surface contour imperfections) were measured and incorporated into the FE model and analysis. In addition, a sensitivity study of the specimens end condition showed that bonding face-sheet doublers to the panel's end, coupled with some stress relief features at corner-edges, can significantly reduce the stress concentrations near the load application points. Ultimately, the jointed panel was subjected to a compressive load. Load application was interrupted at the onset of buckling (at 356 kN 80 kips). A post-test non-destructive evaluation (NDE) showed that, as designed, buckling occurred without introducing any damage into the panel or the joint. The jointed panel was further capable of tolerating an impact damage to the same buckling load with no evidence of damage propagation. The OoA cured all-composite joint shows promise as a low mass factory joint for segmented barrels.
<title>Rigid-body attitude estimation from a single view</title> (1993)

A system for estimating the yaw, pitch, roll, and the three-dimensional position of a rigid body from a single camera view is described. In addition to estimating the six degrees of freedom (six DOF), the system can automatically track the six DOF in a sequence of images. The commercially available image analysis workstation hosting the six DOF algorithm and software is described briefly. An overview of the algorithm's automatic and manual tracking cycle is given. The sensor and scenario parameters influencing the estimation accuracy are discussed. An example of video-theodolite imaging is used to demonstrate the estimation error covariance model.
ChemInform Abstract: Oxidations of 3‐Alkenyltetronic Acids with Dimethyldioxirane (DMD) and Air: Regioselectivity and Formation of a Spirotricyclic Hemiketal Endoperoxide Lactone. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Technology Mapping into General Programmable Cells (2015)

Field-Programmable Gate Arrays (FPGA) implement logic functions using programmable cells, such as K-input lookup-tables (K-LUTs). A K-LUT can implement any Boolean function with K inputs and one output. Methods for mapping into K-LUTs are extensively researched and widely used. Recently, cells other than K LUTs have been explored, for example, those composed of several LUTs and those combining LUTs with several gates. Known methods for mapping into these cells are specialized and complicated, requiring a substantial effort to evaluate custom cell architectures. This paper presents a general approach to efficiently map into single-output K-input cells containing LUTs, MUXes, and other elementary gates. Cells with to 16 inputs can be handled. The mapper is fully automated and takes a logic network and a symbolic description of a programmable cell, and produces an optimized network composed of instances of the given cell. Past work on delay/area optimization during mapping is applicable and leads to good quality of results.
719. Combination of ICOS and 4-1BB in a Third Generation CAR Exhibits Enhanced T Cell Persistence and Increased Antitumor Effect (2015)

T cell persistence is likely to promote long-term antitumor effects after adoptive T cell transfer; however, T cells expressing chimeric antigen receptors (CARs) have not persisted well in patients with solid tumors in trials reported to date. Here, we hypothesized that CD4+ and CD8+ T cells may need distinct costimulation signals to persist. To test this hypothesis, we compared the in vivo antitumor effects and persistence of combined CD4+ and CD8+ T cells redirected with CARs containing different costimulatory domains (CD28, 4-1BB or ICOS). Using multiple mouse tumor models, we demonstrate that the ICOS intracellular domain enhanced the in vivo persistence of CAR-expressing CD4+ T cells. Persistence of CD8+ T cells was highly dependent on the intracellular domain used to redirect CD4+ T cells; specifically, CD4+ T cells expressing an ICOS-based CAR significantly increased the persistence of CD8+ T cells expressing either CD28- or 4-1BB-based CARs. We further demonstrate that the combination of ICOS and 4-1BB in a third generation CAR (ICOSBBz) is more effective at eliminating large pancreatic tumors than either 4-1BB or ICOS alone. T cells redirected with ICOSBBz showed a less differentiated phenotype with superior proliferation and in vivo persistence. These results indicate that ICOSBBz-based CARs are promising therapeutics for clinical testing.
Visible Laser on Silicon Optofluidic Microcavity (2020)

Abstract Optical readout within microfluidic chips is a bottleneck limiting their industrial development. The integration of lasers operating in the visible range within a microfluidic platform is crucial for enabling in situ optical measurements in lab‐on‐a‐chip applications. In principle, microstructured single‐crystal silicon is an excellent optofluidic platform, which allows integration of microfluidic channels together with optical circuits including micro‐optics, waveguides, and resonant cavities. However, the silicon absorption below 1.1 µm is a fundamental limit that prohibits the use of silicon‐based microcavities as the feedback element for visible lasers and restricts their use to the infrared only. In this work, an ultra‐wide band silicon cavity enabled by two deeply etched hollow‐core planar waveguides is demonstrated. The proposed microcavity shows a broad bandwidth extending from 500 to 1600 nm with quality factors up to 2067. A tubular microfluidic channel is inserted between the mirrors of the optofluidic cavity. The microfluidic channel is filled with Rhodamine 6G (R6G) at 20 µL min −1 flow rate allowing successful demonstration of lasing on silicon at 562.4 nm. The laser beam propagates in‐plane (along the chip surface) and is handled with monolithically integrated input/output optical fiber grooves. This provides a unique silicon platform integrating hollow core optofluidic channels together with optical cavities, which is suitable for implementing optical readout in lab‐on‐a‐chip devices.
Collaborative navigation systems for collision avoidance (2010)

Accidents on roads are one of the main causes of human loss and damages to property every day and anywhere that vehicles travel. Communications-based approaches to reducing highway accidents include vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications. However, while V2V and V
APP+, a Fluorescent Analogue of the Neurotoxin MPP+, Is a Marker of Catecholamine Neurons in Brain Tissue, but Not a Fluorescent False Neurotransmitter (2013)

We have previously introduced fluorescent false neurotransmitters (FFNs) as optical reporters that enable visualization of individual dopaminergic presynaptic terminals and their activity in the brain. In this context, we examined the fluorescent pyridinium dye 4-(4-dimethylamino)phenyl-1-methylpyridinium (APP+), a fluorescent analogue of the dopaminergic neurotoxin MPP+, in acute mouse brain tissue. APP+ is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT), and as such represented a candidate for the development of new FFN probes. Here we report that APP+ labels cell bodies of catecholaminergic neurons in the midbrain in a DAT- and NET-dependent manner, as well as fine dopaminergic axonal processes in the dorsal striatum. APP+ destaining from presynaptic terminals in the dorsal striatum was also examined under the conditions inducing depolarization and exocytotic neurotransmitter release. Application of KCl led to a small but significant degree of destaining (approximately 15% compared to control), which stands in contrast to a nearly complete destaining of the new generation FFN agent, FFN102. Electrical stimulation of brain slices at 10 Hz afforded no significant change in the APP+ signal. These results indicate that the majority of the APP+ signal in axonal processes originates from labeled organelles including mitochondria, whereas only a minor component of the APP+ signal represents the releasable synaptic vesicular pool. These results also show that APP+ may serve as a useful probe for identifying catecholaminergic innervations in the brain, although it is a poor candidate for the development of FFNs.
Early Development of Sigma-Receptor Ligands (2010)

Sigma receptors (σ-1 and σ-2) are non-opioid proteins implicated in the pathophysiology of various neurological disorders and cancer. The σ-1 subtype is a chaperon protein widely distributed in the CNS and peripheral tissues. These receptors are involved in the modulation of K(+)- and Ca(2+)-dependent signaling cascades at the endoplasmic reticulum and modulation of neurotransmitter release. σ-1 receptors are emerging targets for the treatment of neurophychiatric diseases (schizophrenia and depression) and cocaine addiction. σ-2 receptors are lipid raft proteins. They are highly expressed on many tumor cells and hence considered potential targets for anticancer drugs. σ receptors bind to a diverse class of pharmacological compounds like cocaine, methamphetamine, benzomorphans like (±)-pentazocine, (±)-SKF-10,047 and endogenous neurosteroids and sphingolipids. In this review we focus on the early development of σ receptor-specific ligands and radiolabeling agents.
Characterization of cubic SiC films grown on thermally oxidized Si substrate (1998)

The growth of cubic SiC films on the thermally oxidized Si substrate is studied by means of hydrogen plasma sputtering of a SiC target. The cubic SiC film without the hollow voids at the film/substrate interface can be grown on the SiO2 layer/Si substrate at 650 °C. The film has stoichiometric composition, and showed well-defined (111) growth at that temperature. There is an etching effect of hydrogen plasma on the substrate before a continuous film is formed over the substrate, and the etch rate depends strongly on the substrate temperature. The plasma etching results in both the breakage of the SiO2 layer and the loss of the substrate Si leading to the hollow voids at the film/substrate interface. There is also an atom migration process between the SiC film, the SiO2 layer, and the Si substrate during the growth of the films. At the substrate temperatures above 750 °C, the adsorbed C atoms diffuse into the Si substrate by different mechanisms, and result in the SiC islands in the Si substrate.
Sodium Flux in Necturus Proximal Tubule under Voltage Clamp (1972)

Na transport and electrical properties of Necturus renal proximal tubules were analyzed, in vivo, by a voltage clamp method which utilizes an axial electrode in the tubule lumen for passage of current and simultaneous determination of net fluid (or Na) flux by the split droplet method. When the average spontaneous transepithelial potential difference of -8 mv (lumen negative) was reduced to zero by current passage, net Na flux doubled from a mean of 107 to 227 pmoles/cm(2) per sec. The relationship between flux and potential over the range -25 to +10 mv was nonlinear, with flux equilibrium at -15 mv and droplet expansion at more negative values. Calculated Na permeability at flux equilibrium was 7.0 x 10(-6) cm/sec. Voltage transients, similar to those caused by intraepithelial unstirred layers, were observed at the end of clamping periods. Tubular electrical resistance measured by brief square or triangle wave pulses (<100 msec) averaged 43 ohm cm(2). The epithelial current-voltage relationship was linear over the range -100 to +100 mv, but displayed marked hysteresis during low frequency (<0.04 Hz) triangle wave clamps. The low transepithelial resistance and large opposing unidirectional ion fluxes suggest that passive ionic movements occur across extracellular shunt pathways, while the voltage transients and current-voltage hysteresis are consistent with the development of a local osmotic gradient within epithelium.
Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome (2021)

Morquio syndrome is a rare disease caused by a disorder in the storage of mucopolysaccharides that affects multiple organs, including musculoskeletal, respiratory, cardiovascular, and digestive systems. Respiratory failure is one of the leading causes of mortality in Morquio patients; thus, respiratory function testing is vital to the management of the disease. An automated respiratory assessment methodology using the <i>pneu</i>RIP device and a machine-learning algorithm was developed. <i>pneu</i>RIP is a noninvasive approach that uses differences between thoracic and abdominal movements (thoracic-abdominal asynchrony) during respiration to assess respiratory status. The technique was evaluated on 17 patients with Morquio (9 females and 8 males) between the ages of 2 and 57 years. The results of the automated technique agreed with the clinical assessment in 16 out of the 17 patients. It was found that the inverse cumulative percentage representation of the time delay between the thorax and abdomen was the most critical variable for accurate evaluation. It was demonstrated that the technique could be successfully used on patients with Morquio who have difficulty breathing with 100% compliance. This technique is highly accurate, portable, noninvasive, and easy to administer, making it suitable for a variety of settings, such as outpatient clinics, at home, and emergency rooms.
Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases (2012)

Nt-acetylation is among the most common protein modifications in eukaryotes. Although thought for a long time to protect proteins from degradation, the role of Nt-acetylation is still debated. It is catalyzed by enzymes called N-terminal acetyltransferases (NATs). In eukaryotes, several NATs, composed of at least one catalytic domain, target different substrates based on their N-terminal sequences. In order to better understand the substrate specificity of human NATs, we investigated in silico the enzyme-substrate interactions in four catalytic subunits of human NATs (Naa10p, Naa20p, Naa30p and Naa50p). To date hNaa50p is the only human subunit for which X-ray structures are available. We used the structure of the ternary hNaa50p/AcCoA/MLG complex and a structural model of hNaa10p as a starting point for multiple molecular dynamics simulations of hNaa50p/AcCoA/substrate (substrate=MLG, EEE, MKG), hNaa10p/AcCoA/substrate (substrate=MLG, EEE). Nine alanine point-mutants of the hNaa50p/AcCoA/MLG complex were also simulated. Homology models of hNaa20p and hNaa30p were built and compared to hNaa50p and hNaa10p. The simulations of hNaa50p/AcCoA/MLG reproduce the interactions revealed by the X-ray data. We observed strong hydrogen bonds between MLG and tyrosines 31, 138 and 139. Yet the tyrosines interacting with the substrate's backbone suggest that their role in specificity is limited. This is confirmed by the simulations of hNaa50p/AcCoA/EEE and hNaa10p/AcCoA/MLG, where these hydrogen bonds are still observed. Moreover these tyrosines are all conserved in hNaa20p and hNaa30p. Other amino acids tune the specificity of the S1' sites that is different for hNaa10p (acidic), hNaa20p (hydrophobic/basic), hNaa30p (basic) and hNaa50p (hydrophobic). We also observe dynamic correlation between the ligand binding site and helix [Formula: see text] that tightens under substrate binding. Finally, by comparing the four structures we propose maps of the peptide-enzyme interactions that should help rationalizing substrate-specificity and lay the ground for inhibitor design.
Excimer laser for 157-nm lithography (1999)

Optical deep UV (DUV) lithography is aiming to reach feature sizes of below 100 nm. The likely choice of the exposure wavelength will be 157 nm, which is emitted by the F<SUB>2</SUB> excimer laser. Experience with this laser type in a variety of applications has been gained at Lambda Physik for the past 20 years. A major breakthrough in performance, in particular laser efficiency and durability, was achieved with the introduction of our metal ceramic laser tube in 1996. In this paper, we report on the progress in the development of the F<SUB>2</SUB> laser light source. A major advance in narrowing the bandwidth of a 10W laser is the achievement of output spectral width of about 1 pm. With a newly developed NovaTube based F<SUB>2</SUB> discharge chamber we show more than 19 million pulses gas lifetime without any additional gas actions. The laser achieves up to 1 kHz repetition rate. Energy stability sigma is 1 percent, dose energy stability 0.5 percent. The performance characteristics as temporal and spatial beam profile and the suitability the laser for microlithography are discussed. Typical lifetimes of the key components and a projection of the present and future cost of operation are presented.
Characterization of the organic-sulfur-degrading enzymes. [IGTS8: a derivative of Rhodococcus rhodochrous] (1991)

The objective of the proposed research is to first characterize the enzymes involved in degrading organic sulfur in coal from some of the well-characterized organic sulfur-degrading strains. After the enzymes have been successfully purified, the genes encoding these enzymes will be cloned and the suitability of these microorganisms for recombinant manipulation will also be studied. Initially, the enzymes involved in the removal of organic sulfur from coal and from model compounds in two particular strains, IGTS8 and K3B, will be characterized and analyzed. The scope of the proposed study covers the following: (1) Characterization, purification, and partial sequence analysis of the enzymes involved in the removal of organic sulfur from coal. (2) Cloning of the genes encoding the organic sulfur-degrading enzymes from these two selected species in E. coli. (3) Sequence analysis of the cloned genes. (4) Attempting to clone and overexpress the organic sulfur degrading genes in their parent hosts as well as in other hosts.
Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition (2020)

GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golgi transport and homotypic fusion of post-mitotic Golgi fragments. Recently, a broader function of mammalian Atg8s on membrane trafficking through interaction with various soluble <i>N</i>-ethylmaleimide-sensitive factor-attachment protein receptors SNAREs was suggested. By immunostaining and microscopic analysis of the Golgi network, we demonstrate the importance of the presence of individual GABARAP-type proteins on Golgi morphology. Furthermore, triple knockout (TKO) cells lacking the whole GABARAP subfamily showed impaired Golgi-dependent vesicular trafficking as assessed by imaging of fluorescently labelled ceramide. With the Golgi apparatus being central within the secretory pathway, we sought to investigate the role of the GABARAP-type proteins for cell surface protein trafficking. By analysing the surfaceome compositionofTKOs, we identified a subset of cell surface proteins with altered plasma membrane localisation. Taken together, we provide novel insights into an underrated aspect of autophagy-independent functions of the GABARAP subfamily and recommend considering the potential impact of GABARAP subfamily proteins on a plethora of processes during experimental analysis of GABARAP-deficient cells not only in the autophagic context.
Preface (2015)

The ever-increasing use of smart phone devices, multimedia applications, and social networking, along with the demand for higher data rates, ubiquitous coverage, and better quality of service, pose new challenges to the traditional mobile wireless network paradigm that depends on macro cells for service delivery. Small cell networks (SCNs) have emerged as an attractive paradigm and hold great promise for future wireless communication systems (5G systems). SCNs encompass a broad variety of cell types, such as micro, pico, and femto cells, as well as advanced wireless relays, and distributed antenna systems. SCNs co-exist with the macro cellular network and bring the network closer to the user equipment. SCNs require low power, incur low cost, and provide increased spatial reuse. Data traffic offloading eases the load on the expensive macro cells with significant savings expected to the network operators using small cells.
Developing a general strategy for the solid supported synthesis of heterocycles: Applications to the generation of molecular diversity and drug discovery (1997)

Abstract
Erhöhte Apoptose von T-regulatorischen Zellen bei Patienten mit aktiver chronisch entzündlicher Darmerkrankung (2011)

Einleitung: Es ist bekannt, dass Patienten mit chronisch entzündlicher Darmerkrankung (CED) eine verminderte Anzahl T-regulatorischer (Treg) Zellen aufweisen, die zur ungenügenden Kompensation chronisch aktivierter Effektor-T-Zellen und damit zur perpetuierten Entzündungsreaktion beitragen. Die Ursache der reduzierten Treg-Zellzahl bei CED-Patienten bleibt unklar.
A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function (2022)

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Such antibodies are typically non-opsonic. However, one antibody could effectively promote vital immune functions, including phagocytosis and in vivo protection. Remarkably, this antibody primarily interacts through a bivalent dual-Fab cis mode, where the Fabs bind to two distinct epitopes in the M protein. The dual-Fab cis-binding phenomenon is conserved across different groups of M types. In contrast, other antibodies binding with normal single-Fab mode to the same region cannot bypass the M protein's virulent effects. A broadly binding, protective monoclonal antibody could be a candidate for anti-streptococcal therapy. Our findings highlight the concept of dual-Fab cis binding as a means to access conserved, and normally non-opsonic regions, regions for protective antibody targeting.
ChemInform Abstract: SYNTHESIS OF THE ISOMERIC PHENOLS AND THE TRANS‐2,3‐DIHYDRODIOL OF FLUORANTHENE (1983)

Abstract Aus Acenaphthylen (I) oder Fluoranthen (VIII) werden die Hydroxyfluoranthene (V), (VI), (XI) und (XVl) hergestellt.
Etude comparative des principaux langages de programmation (1966)

Université : Faculté des sciences de l'Université de Grenoble