gebhart/patrepeval huggingface dataset:
Macrophage Reprogramming by Mycolic Acid Promotes a Tolerogenic Response in Experimental Asthma (2006)

These results document an innate-driven Mycobacterium tuberculosis MA-triggered immune regulatory mechanism in control of pulmonary allergic responses by converting macrophages into IFN-gamma-dependent tolerogenic antigen-presenting cells.
Suppression of streptococcal cell wall–induced arthritis by a potent protease inhibitor, bis(5‐amidino‐2‐benzimidazolyl)methane (1988)

Bis(5-amidino-2-benzimidazolyl)methane, a powerful synthetic trypsin inhibitor, proved to be highly effective in suppressing the arthritis induced by streptococcal cell wall fragments in Lewis rats. It reduced not only the degree of synovitis, osteitis, and hematopoietic hyperplasia in the distal extremities, but also the degree of associated granulomatous inflammation in the liver. The results suggest that trypsin-like proteases play an important role in this arthritis model and that inhibitors may be useful in the treatment of similar arthritic conditions in humans.
VAMAS round‐robin study to evaluate a correction method for saturation effects in D‐SIMS (2014)

Recently, dynamic SIMS (D‐SIMS) is being used to analyze ions simultaneously over a wide range of concentrations, from matrix level to extremely low (ng g −1 ). However, D‐SIMS detectors, which are mostly used in pulse counting systems, have problems with detector saturation. Thus, the ion intensities of SIMS must be corrected in their high‐intensity region. It has been reported that the approximation intermediate extended dead‐time model (a‐IED model) can be used to correct saturated intensity in the higher region better than can the conventional model. In this study, we evaluated the usefulness of the a‐IED model to correct partially saturated and saturated intensities for magnetic‐sector‐type D‐SIMS and quadrupole‐type D‐SIMS for the effects of dead time. Nine organizations from five countries participated in this project. Analyzed specimens were an arsenic‐implanted silicon wafer and a diffused BN onto Si wafer. The instruments used to analyze arsenic‐implanted samples were five quadrupole‐type SIMS and four magnetic‐sector‐type SIMS. The instruments used to analyze the BN‐diffused samples were three quadrupole‐type SIMS, four magnetic‐sector‐type SIMS, and one time‐of‐flight‐type SIMS. We validated the usefulness of the a‐IED model to correct saturated intensities for all SIMS in this round‐robin test. The optimum extension parameter ρ tends to be affected by the ratio of the maximum reliable intensity to the maximum intensity. Copyright © 2014 John Wiley &amp; Sons, Ltd.
Differential Passive Circuit Modelling with Pentapole Impedance Matrices Application to an Integrated Audio Switching Amplifier for Portable Devices (2011)

International audience
Chain Mobility in Crosslinked EPDM Rubbers. Comparison of1H NMR T2Relaxometry and Double-Quantum1H NMR (2011)

1H NMR transverse relaxation and double-quantum (DQ) build up have been compared for a series of EPDM grades crosslinked with different amounts of sulfur or peroxide. The modulus at 100% elongation of the same EPDM samples correlates linearly to the effective transverse-relaxation and DQ build-up rate, suggesting that both rates are proportional to the total network density caused by chain entanglements and crosslinks. For none of the rates, however, the linear trends of sulfur- and peroxide-crosslinked EPDM coincide. This suggests that sulfur- and peroxide-crosslinked EPDM networks are qualitatively different, which is confirmed by different distributions of residual dipolar coupling constants.
Brassica ASTRA: an integrated database for Brassica genomic research (2004)

Brassica ASTRA is a public database for genomic information on Brassica species. The database incorporates expressed sequences with Swiss-Prot and GenBank comparative sequence annotation as well as secondary Gene Ontology (GO) annotation derived from the comparison with Arabidopsis TAIR GO annotations. Simple sequence repeat molecular markers are identified within resident sequences and mapped onto the closely related Arabidopsis genome sequence. Bacterial artificial chromosome (BAC) end sequences derived from the Multinational Brassica Genome Project are also mapped onto the Arabidopsis genome sequence enabling users to identify candidate Brassica BACs corresponding to syntenic regions of Arabidopsis. This information is maintained in a MySQL database with a web interface providing the primary means of interrogation. The database is accessible at http://hornbill.cspp.latrobe.edu.au.
Mesa-Free III-V Nitride Light-Emitting Diodes with Flat Surface (2014)

A mesa-free pn-junction GaInN light-emitting diode (LED) structure is proposed and demonstrated. Some of the p-type top surface area of the LED epitaxial wafer is converted from p-type to n-type by means of Si-ion implantation. The resulting pn-junction LED wafer has cathode and anode contact points at the same surface height so that no dry-etching process is needed to access the n-type region. The measured specific contact resistance on the type-converted n-type layer and the light-output power of the mesa-free pn-junction LED are very comparable to those obtained by a reference LED.
Deep centers and their spatial distribution in undoped GaN films grown by organometallic vapor phase epitaxy (1998)

Deep traps in undoped n-GaN layers grown by organometallic vapor phase epitaxy on sapphire substrates were studied by temperature dependent conductivity, photoinduced current transient spectroscopy (PICTS), thermally stimulated current, electron beam induced current (EBIC), and band edge cathodoluminescence (CL) methods. Presence of electron traps with energy levels 0.1–0.2 eV below the conduction band and hole traps with energy levels of about 0.25, 0.5, and 0.85 eV above the valence band edge was detected. CL and EBIC measurements show that the deep recombination centers in GaN are distributed inhomogeneously with well defined cellular pattern. Both carrier lifetime and luminescence intensity are enhanced at cell walls indicating lower density of recombination centers. However, the density of main hole trap (0.85 eV) is enhanced in these regions as determined by local PICTS measurements. Photoconductivity in many GaN samples exhibits very long decay times at temperatures between 100 and 300 K. The effect most probably is not related to shallow donors such as silicon, but rather is associated with unidentified deep centers with a 0.2 eV barrier for electron capture.
Statistics-Based ICI Mitigation in OFDM over High-Mobility Channels with Line-of-Sight Components (2011)

Statistics-based inter-subchannel interference (ICI) mitigation schemes are developed for orthogonal frequency division multiplexing (OFDM) transmission over high-mobility channels with line-of-sight components. By utilizing the channel statistics, we develop the Wiener filtering in the downlink and the transmit preprocessing in the uplink for ICI mitigation. Numerical and simulation results demonstrate that the proposed schemes effectively mitigate ICI and lower the error floor, especially in the presence of a strong line-of-sight path.
Introduction to the Special Section on Large-Scale Optimization for Audio, Speech, and Language Processing (2013)

The six papers in this special section on large-scale optimization for Audio, Speech, and Language Processing are summarized here.
Synthesis of Novel 3‐N‐substituted Carbazole Derivatives and Evaluation of their Abilities to Inhibit Platelet Aggregation (2018)

The carbazole moiety exhibits various biological activities, including anticancer, antiviral, anti‐inflammatory, and antimicrobial activities; some compounds containing the moiety also inhibit platelet aggregation. In the present study, we synthesized a series of 3‐ N ‐substituted carbazole derivatives and evaluated their abilities to inhibit in vitro platelet aggregation induced by collagen (5 μg/mL). Of the synthesized compounds, compound 5q (JSCa15), with a urea linkage within the carbazole framework, exhibited the strongest inhibitory activity (98.25% at 30 μM). Interestingly, reduction of the nitro group of compound 5q to an amine exhibited significantly decreased activity (compound 5r , 5.18% at 30 μM). Also, substitution of the urea moiety of compound 5q with a carbamate moiety resulted in a considerable loss of activity (compound 8a , 5.91% at 30 μM). These results suggest that the urea moieties and nitro groups of 3‐ N ‐substituted carbazole derivatives may play key roles in inhibiting in vitro platelet aggregation induced by collagen.
An EFTEM Study of Polyimide Adhesion to Single-Walled Carbon Nanotube Bundles (2002)

Journal Article An EFTEM Study of Polyimide Adhesion to Single-Walled Carbon Nanotube Bundles Get access ND Evans, ND Evans Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831-6376 Search for other works by this author on: Oxford Academic Google Scholar C Park, C Park ICASE, NASA Langley Research Center, Hampton VA 23681-2199 Search for other works by this author on: Oxford Academic Google Scholar R Crooks, R Crooks Lockheed Martin Space Operations, NASA Langley Research Center, Hampton VA 23681-2199 Search for other works by this author on: Oxford Academic Google Scholar EJ Siochi, EJ Siochi Advanced Materials and Processing Branch, NASA Langley Research Center, Hampton VA 23681-2199 Search for other works by this author on: Oxford Academic Google Scholar EA Kenik EA Kenik Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831-6376 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 8, Issue S02, 1 August 2002, Pages 638–639, https://doi.org/10.1017/S1431927602106131 Published: 01 August 2002
A Simple and Universal Gel Permeation Chromatography Technique for Precise Molecular Weight Characterization of Well-Defined Poly(ionic liquid)s (2013)

Poly(ionic liquid)s (PILs) are an important class of technologically relevant materials. However, characterization of well-defined polyionic materials remains a challenge. Herein, we have developed a simple and versatile gel permeation chromatography (GPC) methodology for molecular weight (MW) characterization of PILs with a variety of anions. PILs with narrow MW distributions were synthesized via atom transfer radical polymerization, and the MWs obtained from GPC were further confirmed via nuclear magnetic resonance end group analysis.
Optimizing DRX for video delivery over LTE: Utilizing channel prediction and in-network caching (2017)

We jointly optimize Discontinuous Reception (DRX) cycle length and LTE scheduling to minimize mobile devices' energy usage for video delivery, utilising the now well-established potential to predict future channel conditions in cellular networks. Employing in-network caching, we set a strict buffer constraint which provides zero buffer underflow to improve Quality of Experience. Our study provides insight into the energy saving potential sophisticated DRX schemes hold, compared with the currently used static method. To this end, two novel DRX approaches are proposed and studied. The results show that more sophisticated DRX schemes (with variable DRX cycle length) can potentially save 69 percent energy for mobile devices, encouraging further research in the field.
Ibrutinib treatment improves T cell number and function in CLL patients (2017)

The National Cancer Institute.
Description of a New Mutation in Rhodopsin, Pro23Ala, and Comparison With Electroretinographic and Clinical Characteristics of the Pro23His Mutation (2000)

We describe a rare mutation in codon 23 of rhodopsin causing autosomal dominant retinitis pigmentosa. The retinal dystrophy associated with the Pro23Ala mutation is characteristically mild in presentation and course, with greater preservation of ERG amplitudes than the more prevalent Pro23His mutation. Arch Ophthalmol. 2000;118:1269-1276
Variété du travail politique et rapports à la carrière. Le cas des vice-présidents régionaux (2014)

La variété des manières de travailler, d’exercer un mandat, peut être éclairée par des investigations centrées sur les vicissitudes de l’émergence d’un « métier d’élu », caractérisant un ensemble de savoirs requis supposé guider les pratiques, renvoyant à des bonnes façons d’exercer un mandat, et adossé à des apprentissages et socialisations préalables. De façon complémentaire, l’élucidation de cette hétérogénéité du travail politique peut conduire à interroger la conceptualisation si répandue de la « professionnalisation politique », en l’entendant au-delà de son sens wébérien classique comme la capacité d’un groupe – de professionnels – à conquérir et préserver une autonomie dans la maîtrise de son travail, et ce faisant à soumettre celui-ci au contrôle des pairs, supposés définir les bonnes pratiques et assurer le respect des codes de conduite. L’enquête, centrée sur le mandat de vice-président de conseil régional, met clairement en évidence une multiplicité de pratiques chez les élus qui occupent cette fonction, et elle invite non seulement à rendre compte de cette variété mais aussi à en proposer des explications. Pour cela nous avons suivi une piste complémentaire aux voies évoquées précédemment : elle consiste à informer les manières dont les élus travaillent, et interprètent différemment leur fonction, en les articulant avec leurs positions et leurs parcours sur le marché du travail politique et au sein du monde professionnel de référence.
Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants (1997)

Electrophysiological and pharmacological studies of a cloned human dopamine transporter (hDAT) were undertaken to investigate the mechanisms of transporter function and the actions of drugs at this target. Using two-electrode voltage-clamp techniques with hDAT-expressing Xenopus laevis oocytes, we show that hDAT can be considered electrogenic by two criteria. (1) Uptake of hDAT substrates gives rise to a pharmacologically appropriate "transport-associated" current. (2) The velocity of DA uptake measured in oocytes clamped at various membrane potentials was voltage-dependent, increasing with hyperpolarization. Concurrent measurement of transport-associated current and substrate flux in individual oocytes revealed that charge movement during substrate translocation was greater than would be expected for a transport mechanism with fixed stoichiometry of 2 Na+ and 1 Cl- per DA+ molecule. In addition to the transport-associated current, hDAT also mediates a constitutive leak current, the voltage and ionic dependencies of which differ markedly from those of the transport-associated current. Ion substitution experiments suggest that alkali cations and protons are carried by the hDAT leak conductance. In contrast to the transport-associated functions, the leak does not require Na+ or Cl-, and DAT ligands readily interact with the transporter even in the absence of these ions. The currents that hDAT mediates provide a functional assay that readily distinguishes the modes of action of amphetamine-like "DA-releasing" drugs from cocaine-like translocation blockers. In addition, the voltage dependence of DA uptake suggests a mechanism through which presynaptic DA autoreceptor activation may accelerate the termination of dopaminergic neurotransmission in vivo.
Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non‐human primates (NHPs) exposed to radiation (2018)

Acetylcarnitine has been identified as one of several urinary biomarkers indicative of radiation exposure in adult rhesus macaque monkeys (non-human primates, NHPs). Previous work has demonstrated an up-regulated dose-response profile in a balanced male/female NHP cohort. As a contribution toward the development of metabolomics-based radiation biodosimetry in human populations and other applications of acetylcarnitine screening, we have developed a quantitative, high-throughput method for the analysis of acetylcarnitine. We employed the Sciex SelexIon DMS-MS/MS QTRAP 5500 platform coupled to flow injection analysis (FIA), thereby allowing for fast analysis times of less than 0.5 minutes per injection with no chromatographic separation. Ethyl acetate is used as a DMS modifier to reduce matrix chemical background. We have measured NHP urinary acetylcarnitine from the male cohorts that were exposed to the following radiation levels: control, 2, 4, 6, 7, and 10 Gy. Biological variability, along with calibration accuracy of the FIA-DMS-MS/MS method, indicates LOQ of 20 μM, with observed biological levels on the order of 600 μM and control levels near 10 μM. There is an apparent onset of intensified response in the transition from 6 to 10 Gy. The results demonstrate that FIA-DMS-MS/MS is a rapid, quantitative technique that can be utilized for the analysis of urinary biomarker levels for radiation biodosimetry.
Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer (1997)

The tumor suppressor gene CDKN2 (p16/MTS1) resides on chromosome 9p21 and encodes a 16 kDa inhibitor of the cyclin-dependent kinases. Inactivation of CDKN2 by homozygous deletion, point mutation, and recently described aberrant methylation in the 5′ promoter region may increase progression through the cell cycle in tumors. In this study, we examine the CDKN2 gene for the presence of inactivating alterations in human prostate cancer. Sequence analysis of cell lines revealed no mutation in LNCaP, PC3, and TSU-PRI and a missense mutation, GAC→TAC(asp to tyr), in exon 2 of the DU145 cell line at codon 76. No mutations were identified in three primary prostate cancers or in seven lymph node metastases. Loss of heterozygosity (LOH) was analyzed by analysis of microsatellite markers in the vicinity of the CDKN2 gene. LOH was detected in 12 (20%) of 60 primary tumors at one or more loci and in 13 (46%) of 28 metastases. Methylation analysis of the CpG-rich promoter region revealed a dense methylation of CDKN2 in cell lines PC3, PPCI, and TSU-PR1, and this was found to correlate with a lack of mRNA expression by reverse transcription-polymerase chain reaction. A demethylating agent. 5-aza-2′-deoxycytidine, induced reexpression when cells were exposed in vitro. DU145 and LNCaP expressed the CDKN2 transcript and were unmethylated in the promoter region. Three of twenty-four (13%) primary prostate cancers and 1 of 12 metastatic tumors demonstrated promoter methylation. No normal prostate tissues were methylated at the CDKN2 gene promoter. One tumor was found to contain concomitant LOH and promoter methylation indicative of biallelic inactivation. A comprehensive analysis of CDKN2 in prostate cancer reveals that point mutations are infrequent, but gene deletion and methylation combine to inactivate CDKN2 in a subset of tumors. Moreover, alterations in this gene may represent a late event in prostate cancer progression. Genes Chromosom. Cancer 19:90–96, 1997. © 1997 Wiley-Liss, Inc.
Tuning the properties of visible-light-responsive tantalum (oxy)nitride photocatalysts by non-stoichiometric compositions: a first-principles viewpoint (2014)

Finding an ideal photocatalyst for achieving efficient overall water splitting still remains a great challenge. By applying accurate first-principles quantum calculations based on DFT with the screened non-local hybrid HSE06 functional, we bring rational insights at the atomic level into the influence of non-stoichiometric compositions on essential properties of tantalum (oxy)nitride compounds as visible-light-responsive photocatalysts for water splitting. Indeed, recent experiments show that such non-stoichiometry is inherent to the nitridation methods of tantalum oxide with unavoidable oxygen impurities. We considered here O-enriched Ta3N5 and N-enriched TaON materials. Although their structural parameters are found to be very similar to those of pure compounds and in good agreement with available experimental studies, their photocatalytic features for visible-light-driven overall water splitting reactions show different behaviors. Further partial nitration of TaON leads to a narrowed band gap, but partially oxidizing Ta3N5 causes only subtle changes in the gap. The main influence, however, is on the band edge positions relative to water redox potentials. The pure Ta3N5 is predicted to be a good candidate only for H(+) reduction and H2 evolution, while the pure TaON is predicted to be a good candidate for water oxidation and O2 evolution. Non-stoichiometry has here a positive influence, since partially oxidized tantalum nitride, Ta(3-x)N(5-5x)O5x (for x≥ 0.16) i.e. with a composition in between TaON and Ta3N5, reveals suitable band edge positions that correctly bracket the water redox potentials for visible-light-driven overall water splitting reactions. Among the various explored Ta(3-x)N(5-5x)O5x structures, a strong stabilization is obtained for the configuration displaying a strong interaction between the O-impurities and the created Ta-vacancies. In the lowest-energy structure, each created Ta-vacancy is surrounded by five O-impurity species substituting the five N sites characterizing one octahedral environment.
Preface to the Chemistry of Materials Special Issue: Synthetic and Mechanistic Advances in Nanocrystal Growth (2013)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTPreface to the Chemistry of Materials Special Issue: Synthetic and Mechanistic Advances in Nanocrystal GrowthBenoit Dubertret, Jennifer Hollingsworth, Haitao Liu, Delia Milliron, Jonathan Owen, Emily Weiss, William E. Buhro, Frank Caruso, Susan M. Kauzlarich, and Michael WardCite this: Chem. Mater. 2013, 25, 8, 1153–1154Publication Date (Web):April 23, 2013Publication History Published online23 April 2013Published inissue 23 April 2013https://pubs.acs.org/doi/10.1021/cm4008359https://doi.org/10.1021/cm4008359editorialACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1226Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (120 KB) Get e-AlertscloseSUBJECTS:Crystals,Nanocrystals,Nanoparticles,Optical properties,Quantum dots Get e-Alerts