gebhart/patrepeval huggingface dataset:
Small Signal Model of Dual Active Bridge Converter for Multi-Phase Shift Modulation (2020)

The derivation of small signal model of bidirectional dc-dc dual active bridge (DAB) converter under multi-phase shift including the conventional single phase shift (SPS), dual phase shift (DPS) and triple phase shift (TPS) modulation is presented in this paper. Full order continuous time generalized average model has been developed for different modulation strategies and control variables to output voltage transfer functions analytical equations have been derived. Also, open loop responses of the DAB converter based on the developed model have been plotted and frequency response estimation simulation is performed in Simulink to compare the accuracy of the model. Finally, a proportional integral (PI) controller has been designed for each of the modulation methods and the effectiveness of the controller has been demonstrated through simulation.
Frequency selectable induction heating targets (2004)

This paper examines a scheme for developing frequency selectable induction heating targets for stimulating temperature sensitive polymer actuators. "Frequency selectable" implies that each target has a frequency at which it heats preferentially compared to other remaining targets. Single-turn conductors whose critical dimensions are small compared to their associated skin depth (over the frequency range of interest) are examined. One way to achieve selectivity with frequency is by designing each target to have the same self-inductance, while forcing the resistance of each target to differ from the previous one by a specified factor, /spl alpha/. In this way, a target driven at its R/L break-point frequency, will heat by at least a factor of (/spl alpha//sup 2/ + 1)/(2/spl alpha/) more than the remaining targets.
Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single‐Step Process (2009)

Surface-engineered microparticles with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free-flowing dispersions below 37 °C, but form porous space-filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Synthetic SOD/Catalase Mimic Compound for the Treatment of ALS (2021)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. To date, the etiology of the disease is still unclear, with evidence of reactive oxygen species, mitochondrial dysfunction, iron homeostasis perturbation, protein misfolding and protein aggregation as key players in the pathology of the disease. Twenty percent of familial ALS and two percent of sporadic ALS instances are due to a mutation in Cu/Zn superoxide dismutase (SOD1). Sporadic and familial ALS affects the same neurons with similar pathology; therefore, the underlying hypothesis is that therapies effective in mutant SOD1 models could be translated to sporadic ALS. Corrole metal complexes have lately been identified as strong and potent catalytic antioxidants with beneficial effects in oxidative stress-related diseases such as Parkinson's disease, Alzheimer's disease, atherosclerosis, diabetes and its complications. One of the most promising candidates is the iron complex of an amphiphilic corrole, <b>1-Fe</b>. In this study we used the SOD1 G93R mutant zebrafish ALS model to assess whether <b>1-Fe</b>, as a potent catalytic antioxidant, displays any therapeutic merits in vivo. Our results show that <b>1-Fe</b> caused a substantial increase in mutant zebrafish locomotor activity (up to 30%), bringing the locomotive abilities of the mutant treated group close to that of the wild type untreated group (50% more than the mutated untreated group). Furthermore, <b>1-Fe</b> did not affect WT larvae locomotor activity, suggesting that <b>1-Fe</b> enhances locomotor ability by targeting mechanisms underlying SOD1 ALS specifically. These results may pave the way for future development of <b>1-Fe</b> as a viable treatment for ALS.
Stigmata of amyloidosis; external manifestations of internal disease (2019)

A 62-year-old man was referred for evaluation for heart transplantation for refractory non-ischaemic cardiomyopathy diagnosed a year previously. Physical examination showed non-blanching purpuric skin lesions involving the upper trunk and neck, suggestive of amyloid purpura, macroglossia (top) and dystrophic changes of the nails (bottom). He had first noted the relapsing and remitting skin rash 4 years previously and the gradually progressive nail changes had developed over the previous 3 years. He reported surgical release of median nerves 2 years previously for bilateral carpal tunnel syndrome. An electrocardiogram showed low QRS voltage and “pseudoinfarct pattern or Q waves in V1–V3”. Further evaluation revealed nephrotic range proteinuria and markedly elevated serum lambda light chains of 700 mg/l (normal range: 5·7–26·3 mg/l). An endomyocardial biopsy stained with Congo red was diagnostic of amyloidosis. Amyloidosis is a rare and often fatal disease in which an amyloidogenic protein is deposited in tissues, causing organ damage. Diagnosis is made by biopsy of the involved organ or a surrogate site, such as abdominal fat pad. On tissue biopsy stained with Congo red and viewed microscopically under polarized light, amyloid produces a pathognomonic apple green birefringence. Light chain-associated amyloidosis (AL amyloidosis) is the most common type and is caused by deposition of altered free light chain protein produced by an underlying plasma cell neoplasm. The neoplastic clone can be therapeutically targeted using a proteasome inhibitor, such as bortezomib, or autologous haematopoietic stem cell transplantation following melphalan-based conditioning, leading to improved survival. It is important to recognize amyloid purpura, macroglossia, onychodystrophy and carpal tunnel syndrome as external manifestations of amyloidosis. Clinicians should suspect a diagnosis of amyloidosis with such findings. Unfortunately, the patient died suddenly as a result of a fatal cardiac arrhythmia after receiving one cycle of bortezomib-based therapy. AL amyloidosis with advanced cardiac involvement carries very poor prognosis.
Extraction of instantaneous and rms sinusoidal jitter using an analytic signal method (2003)

This paper describes a new method for extracting both instantaneous and rms sinusoidal jitter from phase-locked loops (PLL) output signals. The method is based on analytic signal theory and utilizes the Hilbert transform to extract phase information from a PLL signal. Both the theoretical basis and fundamental concepts of the new method are explained. A unified review of conventional methods is also presented. Results of Matlab simulations validate the performance of the new method for measuring jitter, and it is further validated by comparing experimental sinusoidal jitter results with those of a time interval analyzer.
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness (2015)

By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mammary stemlike cells and found that such cells apportion aged mitochondria asymmetrically between daughter cells. Daughter cells that received fewer old mitochondria maintained stem cell traits. Inhibition of mitochondrial fission disrupted both the age-dependent subcellular localization and segregation of mitochondria and caused loss of stem cell properties in the progeny cells. Hence, mechanisms exist for mammalian stemlike cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties.
Alleviating a form of electric vehicle range anxiety through On-Demand vehicle access (2013)

On-demand vehicle access is a method that can be used to reduce types of range anxiety problems related to planned travel for electric vehicle owners. Using ideas from elementary queueing theory, basic QoS metrics are defined to dimension a shared fleet to ensure high levels of vehicle access. Using mobility data from Ireland, it is argued that the potential cost of such a system is very low.
Molecular and immunological paradigms of hepatocellular carcinoma: Special reference to therapeutic approaches (2020)

The development of hepatocellular carcinoma (HCC) is a multistep process with a complex interaction of various genetic backgrounds and the tumor microenvironment. In addition to the development of rational approaches to epidemiologic research, early detection, and diagnosis, considerable progress has been made in systemic treatment with molecular-targeted agents for patients with advanced HCC. Moreover, encouraging reports of recent clinical trials of combination therapy with immune-checkpoint inhibitors (ICIs) has raised high hopes. Each HCC is the result of a unique combination of somatic alterations, including genetic, epigenetic, transcriptomic, and metabolic events, leading to conclusive tumoral heterogeneity. Recent advances in comprehensive genetic analysis have accelerated molecular classification and defined subtypes with specific characteristics, including immune-associated molecular profiles reflecting the immune reactivity in the tumor. In considering the development of therapeutic strategies in combination with immunotherapy, proper interpretation of molecular pathological characterization could lead to effective therapeutic deployment and enable individualization of the management of HCC. Here, we review distinctive molecular alterations in the subtype classification of HCC, current therapies, and representative clinical trials with alternative immune-combination approaches from a molecular pathological point.
Distributional Similarity Model for Multi-modality Clustering in Social Media (2007)

User generated content (UGC) has become the fastest growing sector of the WWW. Data mining from UGC presents challenges not typically found in text mining from documents. UGC can be semi-structured and its content can be very short and informal, containing relatively little content similar to a chat or an email conversation. In addition UGC can be viewed as a multi-modality data. These characteristics pose big challenges and research questions for scholars to cope with. To cluster UGC data, we can construct multiple contingency tables of modalities and employ the multi-way distributional clustering (MDC) algorithm. However, by considering a contingency table which summarizes the co-occurrence statistics of two modalities, it is not robust to represent the information entropy between two modalities in UGC data. In this paper, we propose a novel similarity measurement, called distributional similarity model (DSM), to solidify the graph model in the MDC algorithm to deal with the unique characteristics of the UGC data.
Performance evaluation of spatial compounding in the presence of aberration and adaptive imaging (2003)

Spatial compounding has been used for years to reduce speckle in ultrasonic images and to resolve anatomical features hidden behind the grainy appearance of speckle. Adaptive imaging restores image contrast and resolution by compensating for beamforming errors caused by tissue-induced phase errors. Spatial compounding represents a form of incoherent imaging, whereas adaptive imaging attempts to maintain a coherent, diffraction-limited aperture in the presence of aberration. Using a Siemens Antares scanner, we acquired single channel RF data on a commercially available 1-D probe. Individual channel RF data was acquired on a cyst phantom in the presence of a near field electronic phase screen. Simulated data was also acquired for both a 1-D and a custom built 8x96, 1.75-D probe (Tetrad Corp.). The data was compounded using a receive spatial compounding algorithm; a widely used algorithm because it takes advantage of parallel beamforming to avoid reductions in frame rate. Phase correction was also performed by using a least mean squares algorithm to estimate the arrival time errors. We present simulation and experimental data comparing the performance of spatial compounding to phase correction in contrast and resolution tasks. We evaluate spatial compounding and phase correction, and combinations of the two methods, under varying aperture sizes, aperture overlaps, and aberrator strength to examine the optimum configuration and conditions in which spatial compounding will provide a similar or better result than adaptive imaging. We find that, in general, phase correction is hindered at high aberration strengths and spatial frequencies, whereas spatial compounding is helped by these aberrators.
Durable Link Slabs for Jointless Bridge Decks Based on Strain-Hardening Cementitious Composites (2003)

The research presented herein describes the development of durable link slabs for jointless bridge decks based on strainhardening cementitious composite - engineered cementitious composite (ECC). Specifically the superior ductility of ECC was utilized to accommodate bridge deck deformations imposed by girder deflection, concrete shrinkage, and temperature variations, providing a cost-effective solution to a number of deterioration problems associated with bridge deck joints. Current design concept of link slabs was first examined to form the basis of design for ECC link slabs. Microstructurally optimized ECC material, with good workability and satisfactory mechanical properties was then developed. After the material design, the shrinkage, shrinkage crack resistance and the freeze-thaw behavior of the pre-selected mix proportion was investigated and revealed excellent for the durability concern. Improved design of ECC link slab/concrete deck slab interface was confirmed in numerical analysis and further strengthened by excellent reinforcement pullout and shear stud pushout behavior in ECC. Based on the above findings, monotonic and subsequent cyclic tests of full-scale ECC link slab specimens were performed and compared with those of a conventional concrete link slab. It was revealed that the inherent tight crack width control of ECC decouples the dependency of crack width on the amount of reinforcement. This decoupling allows the simultaneous achievement of structural need (lower flexural stiffness of the link slab approaching the behavior of a hinge) and durability need (crack width control) of the link slab. Overall investigation supports the contention that durable jointless concrete bridge decks may be designed and constructed with ECC link slabs. Finally, a simple design guideline is presented.
Supplementary Data from Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation (2023)

&lt;p&gt;PBMC RNAseq Raw Transcript Counts&lt;/p&gt;
Facile Deposition of Nb2O5 Thin Film as an Electron-Transporting Layer for Highly Efficient Perovskite Solar Cells (2018)

In a typical high-performance perovskite solar cell (PSC), the electron-transporting layer (ETL) plays a critical role in facilitating the transportation of the photogenerated carriers from perovskite to electrode. In the present work, the solution-processed Nb2O5 film is successfully prepared to serve as an alternative for replacing the overwhelmingly dominated TiO2 ETL with a facile deposition approach. By adjusting the spin-coating process of the precursor solution, the best power conversion efficiency of 19.2% is achieved in the Nb2O5-based planar PSC when the thickness of C–Nb2O5 ETL is about 100 nm. The characterization including ultraviolet photoelectron spectroscopy, electronic impedance spectroscopy, and photoluminescence spectrum results elucidate that the impressive photovoltaic performances can be attributed to the proper Nb2O5 ETL conductive band, the lower charge recombination rate, the more efficient extraction, and transportation of the photogenerated carriers from the perovskite absorber.
Switched-current technique for video compression and quantization (2003)

Portable consumer products need low-cost, low-power chips for realization of signal processing and image compression functions. In this paper a modification of such a chip for a digital video camera is presented. The chip contains an image sensing array composed of photodiodes, a two-dimensional DCT processor and an entropy coding section. The processor is designed in a switched-current (SI) technique and contains current mirrors and memory cells. In order to examine these elementary cells, an experimental chip in AMS 0.8 /spl mu/m technology was fabricated.
3D Cell‐Migration Studies using Two‐Photon Engineered Polymer Scaffolds (2008)

We use two-photon polymerization to fabricate 3D scaffolds with precise control over pore size and shape for studying cell migration in 3D. These scaffolds allow movement of cells in all directions. The fabrication, imaging, and quantitative analysis method developed here can be used to do systematic cell studies in 3D.
TALE-induced bHLH transcription factors that activate a pectate lyase contribute to water soaking in bacterial spot of tomato (2017)

AvrHah1 [avirulence (avr) gene homologous to avrBs3 and hax2, no. 1] is a transcription activator-like (TAL) effector (TALE) in Xanthomonas gardneri that induces water-soaked disease lesions on fruits and leaves during bacterial spot of tomato. We observe that water from outside the leaf is drawn into the apoplast in X. gardneri-infected, but not X. gardneriΔavrHah1 (XgΔavrHah1)-infected, plants, conferring a dark, water-soaked appearance. The pull of water can facilitate entry of additional bacterial cells into the apoplast. Comparing the transcriptomes of tomato infected with X. gardneri vs. XgΔavrHah1 revealed the differential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effector binding elements (EBEs) for AvrHah1. We mined our RNA-sequencing data for differentially up-regulated genes that could be direct targets of the bHLH transcription factors and therefore indirect targets of AvrHah1. We show that two pectin modification genes, a pectate lyase and pectinesterase, are targets of both bHLH transcription factors. Designer TALEs (dTALEs) for the bHLH transcription factors and the pectate lyase, but not for the pectinesterase, complement water soaking when delivered by XgΔavrHah1 By perturbing transcriptional networks and/or modifying the plant cell wall, AvrHah1 may promote water uptake to enhance tissue damage and eventual bacterial egression from the apoplast to the leaf surface. Understanding how disease symptoms develop may be a useful tool for improving the tolerance of crops from damaging disease lesions.
ChemInform Abstract: Radical Isomerization and Allylation Reactions of 2‐Iodo‐3,3‐dimethyl‐ 4‐pentenoate Esters. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetic capture of endothelial cells to vascular stents within an externally applied magnetic field. (2013)

A method based on the high-frequency ultrasonic guided waves (UGWs) of a piezoelectric sensor array is proposed to monitor the depth of transverse cracks in rail bottoms. Selecting high-frequency UGWs with a center frequency of 350 kHz can enable the monitoring of cracks with a depth of 3.3 mm. The method of arranging piezoelectric sensor arrays on the upper surface and side of the rail bottom is simulated and analyzed, which allows the comprehensive monitoring of transverse cracks at different depths in the rail bottom. The multi-value domain features of the UGW signals are further extracted, and a back propagation neural network (BPNN) is used to establish the evaluation model of the transverse crack depth for the rail bottom. The optimal evaluation model of multi-path combination is reconstructed with the minimum value of the root mean square error (RMSE) as the evaluation standard. After testing and comparison, it was found that each metric of the reconstructed model is significantly better than each individual path; the RMSE is reduced to 0.3762; the coefficient of determination R<sup>2</sup> reached 0.9932; the number of individual evaluation values with a relative error of less than 10% and 5% accounted for 100% and 87.50% of the total number of evaluations, respectively.
Viscosity Peak due to Shape Transition from Wormlike to Disklike Micelles: Effect of Dodecanoic Acid (2018)

Here, we have investigated the synergistic growth of long wormlike micelles and their transformation into disklike micelles, which occurs in three-component solutions composed of sodium lauryl ether sulfate (SLES; anionic), cocamidopropyl betaine (CAPB; zwitterionic), and dodecanoic acid (HC12; nonionic). The solution rheology is characterized in terms of zero-shear viscosities and characteristic times for micellar breaking and reptation. Furthermore, the microstructure evolution, leading to the observed rheological behavior, is revealed by cryo-transmission electron microscopy (TEM) micrographs. In all cases, the CAPB-to-SLES ratio is fixed, whereas the fatty acid concentration is varied. At a certain HC12 concentration, the solution viscosity passes through a maximum. The cryo-TEM imaging indicates that wormlike micelles appear before the peak, grow further up to the peak, and finally transform into disklike aggregates (a very rare micellar structure) after the peak. The transformation of worms into disks leads to a drop in viscosity because the length-to-thickness aspect ratio of the disks is significantly lower than that of the worms. In this article, we elucidate the structure-rheology relations in micellar solutions that might be applied for the design of personal-care and household formulations.
Marine Natural Products as Prototype Insecticidal Agents (1997)

In an attempt to characterize additional structural classes that could serve as prototypes for insecticides, 26 structurally diverse marine compounds were examined for insecticidal activity in a diet overlay assay against newly hatched larvae of the southern corn rootworm, Diabrotica undecimpunctata howardi, and the tobacco budworm, Heliothis virescens. Several new classes of compounds have been identified as having potential as lead compounds for the development of new marine-derived insecticides. Keywords: Insecticidal activity; marine natural products; briaranes; halichondramide; swinholides