gebhart/patrepeval huggingface dataset:
Intravascular ultrasound elasticity-palpography technique for mechanicalcharacterization of coronary plaque anisotropy (2017)

International audience
Supplementary Figure 2 from Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation (2023)

Supplementary Figure 2 from Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
A wideband lumped circuit model of eddy current losses in a coil with a coaxial insulation system and a stranded conductor (2003)

This paper presents a wideband lumped circuit model of eddy current losses in a coaxially insulated coil. The wide frequency range of the model is achieved by means of dual and extended Cauer circuits, which are equivalent circuits used for eddy current modeling. The complete lumped circuit reproduces the expected response well. However, because of resonances in the coil, the model cannot be experimentally verified for higher frequencies than 5 kHz. The parameters of the lumped circuit are mainly acquired from field calculations and aggregate the eddy current losses in the stranded conductor of each turn. The aggregate considers the contact resistance between the strands. The eddy current model can be used as a part of a complete model of the coil intended for, e.g., lightning impulse simulations, as the winding is discretised into short pieces. The results of the paper are of special interest for coaxially insulated electric machines, such as the commercially available Powerformer/spl trade/ and Dryformer/spl trade/.
Biosynthetic Capacities of Actinomysetes. No.26. Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus. I. Taxonomy, Fermentation, Isolation and Biological Activities. (2002)

Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).
Scintillation Properties of Ga<sub>2</sub>O<sub>3</sub> Translucent Ceramics Annealed at Different Temperatures (2023)

Annealing temperature dependence on optical and scintillation properties of the β-gallium oxide (β-Ga2O3) translucent ceramic has been investigated. The Ga2O3 translucent ceramic was prepared by spark plasma sintering and annealed in air. All the ceramics showed the broad emissions peaking at 390—410 nm due to the recombination of defect-related donors and acceptors. The ceramics annealed at 1000—1100°C showed ultraviolet emission at around 350 nm due to increase in transmittance which was caused by decrease in oxygen vacancies. Under α-ray excitation from 241Am, the scintillation light yield of the ceramic annealed at 1000°C was the highest among all the ceramics, and the value was 2300 photons/5.5 MeV-α.
Fast and effective tuned coupling for mono-mode microwave power applicators (2016)

A new concept for variation of coupling between a mono-mode applicator and a waveguide input is described. It provides a possibility for continuous tuning of the coupling factor, so that very good matching of the applicator is maintained while temperature modifies the loss factor of the heated material. The tuning is simple and much more convenient than a typical matching with a three-stub tuner. It is a very low-loss solution applicable also at very high power, even of the order of hundreds of kW.
Method for measurement of collagen monomer orientation in fluorescence microscopy (2021)

Collagen is one of the most important proteins in mammals, conforming most animal tissues. This work explores how a basic collagen monomer unit is visualized using fluorescence microscopy and how its spatial orientation is determined. Defining the orientation of collagen monomers is not a trivial problem, as the particle has a weak contrast and is relatively small. Possible attach fluorescence tags for contrast, but the size is still a problem for detecting orientation using fluorescence microscopy. This document presents a simulation of the visualization of collagen monomers and two methods for detecting monomer and classifying its orientation. A modify Gabor filter set, and an automatic classifier, trained by convolutional neuronal network (CNN), were used. By evaluating the performance of these two approaches compare to human observation, our results show that it is possible to determine the location and orientation of a single monomer with fluorescence microscopy. These findings can contribute to understanding collagen elements as collagen fibril.
Prospective Evaluation of Terazosin for the Treatment of Autonomic Dysreflexia (1994)

Terazosin was evaluated in 21 normotensive spinal cord injured patients with autonomic dysreflexia. The patients were followed for 3 months during which the autonomic dysreflexia severity and frequency were evaluated. Autonomic dysreflexia severity mean score was significantly improved when measured at baseline and at 1 week, 1 month and 3 months (10.3 +/- 4.2, 5.08 +/- 2.3, 3.83 +/- 2.5 and 4.5 +/- 1.4, respectively, p < 0.0005). No statistically significant change was seen in erectile function and blood pressure. Three patients complained of fatigue, 1 of whom had the dosage reduced from 5 to 2.5 mg. daily. Terazosin appears to be effective in preventing serious harm from autonomic dysreflexia without erectile function impairment. The effectiveness is significant in the first week and remains for at least 3 months.
A-C temperature compensation and integrated amplifiers (1963)

One of the more troublesome characteristics of a transistor is its rather pronounced sensitivity to temperature.1,2 Consequently, in the design of a transistor circuit it is necessary to provide diligently for changes in device parameters resulting from both self-heating effects and ambient variations. Of primary importance is the stabilization of the d-c operating point.3,4 In addition, it is often necessary to obtain temperature-stable a-c performance in a transistor circuit. In the case of small signal amplifiers, an analytical basis for a-c temperature compensation is not generally available at the present time.5 This paper describes a fairly simple yet accurate design theory whereby the temperature variations in the transistor small signal parameters are effectively compensated by a minimum of passive elements. The result is an integrated amplifier whose current gain, voltage gain, power gain, input impedance, and output impedance are virtually insensitive to temperature. The amplifier is termed integrated since the required compensation may best be accomplished first, by analyzing the circuit as an entity, and second, by mounting all components on or within a common substrate.
H- ras Activation in Benign and Self-Regressing Skin Tumors (Keratoacanthomas) in Both Humans and an Animal Model System (1988)

The involvement of the ras oncogenes in tumorigenesis was investigated in keratoacanthomas, which are benign and self-regressing skin tumors, both in humans and in a corresponding animal model system. Keratoacanthomas were induced on rabbit ears by repeated applications of 7,12-dimethylbenz(a)anthracene. About 60% of the tumor DNAs produced transformed foci after transfection into NIH 3T3 cells, and in all of them the transforming gene was identified as H-ras by Southern and Northern (RNA) hybridization. Immunoprecipitation experiments suggested that the transforming rabbit H-ras protein carried a mutation in codon 61. In addition, an activated H-ras gene was detected in a human keratoacanthoma by using a nude mouse tumorigenesis assay after transfection of tumor DNA into NIH 3T3 cells. This is the first report of ras activation in a benign human tumor. The transforming human H-ras gene showed a point mutation in codon 61 that would result in leucine instead of the glutamine present in the normal gene product. The finding of ras activation in tumors that are not only benign but also self-regressing indicates that activated ras genes are not sufficient to maintain a neoplastic phenotype, although they likely play a role in early stages of tumorigenesis.
Maximum Incorporation of Oxygen Radicals, O- and O2-, into 12CaO·7Al2O3 with a Nanoporous Structure (2003)

The effects of oxygen partial pressure (pO2) up to 400 atm on the generation of active oxygen radicals in 12CaO·7Al2O3 (C12A7) was examined using a hot isostatic pressing technique. Concentrations of superoxide (O2-) and oxygen anion radicals (O-), which were analyzed from a combination of electron paramagnetic spin resonance (EPR) and Raman spectroscopy, increased with pO2. The total concentration of the radicals reached 1.7 × 1021 cm3, which is comparable to the theoretical maximum, confirmed that dominant radical incorporation process is O2- (cage) + O2 (atmosphere) → O- (cage) + O2- (cage). The radical incorporated C12A7 has a large magnetic susceptibility that obeys Curie's law down to 2.5 K without magnetic ordering, although a weak exchange interaction was suggested by the line narrowing of the EPR signal.
Quantitative description of charge-carrier transport in a white organic light-emitting diode (2011)

We present a simulation model for the analysis of charge-carrier transport in organic thin-film devices, and apply it to a three-color white hybrid organic light-emitting diode (OLED) with fluorescent blue and phosphorescent red and green emission. We simulate a series of single-carrier devices, which reconstruct the OLED layer sequence step by step. Thereby, we determine the energy profiles for hole and electron transport, show how to discern bulk from interface limitation, and identify trap states.
Discrete Phase Analysis of Self Heating Particles Over an Immersion Liquid Cooled High Power Blue Light-Emitting Diode With Suspended Phosphor Particles (2022)

Abstract In recent years, the interaction of unrestricted particles with dispersed multiphase flows has been linked to a number of important engineering applications. Among these applications, the novel idea of immersion-cooled phosphor particles, which has the potential of significantly increasing the thermal limits of phosphor converted white light-emitting diode (LEDs) (Pc-WLEDs), has yet to be thoroughly investigated. With this objective, this research utilizes the discrete phase modeling (DPM) technique for the characterization of phosphor location and movements within a buoyancy-driven flow, which is the determining factor in the optical behavior of the newly proposed Pc-WLED configuration. Two-phase flow analysis is conducted to characterize particle movement. Heat transfer, flow, and energy paths of self-heating phosphor particles are extracted, and the influence of particle sizes is analyzed in detail. The results show that with immersion liquid cooling, the highest phosphor particle temperature is recorded to be under 420 K, while larger size particles introduce higher heat transfer rates to the Pc-WLED package for the same number of particles. Moreover, depending on the particle size and position, individual phosphor particles can follow a different trajectory that can affect the probability of obtaining white light emission.
Influence of Defects on the Properties of a 2D Ferroelectric: A Monte-Carlo Simulation Study (2002)

In this article, Monte-Carlo simulation methods were used to investigate the influence of different types of defects on the properties of a 2-dimensional ferroelectric. To this end, a recently published model by B. G. Potter et al. [J. Appl. Phys. 87 (2000) 4415] was extended to include simple defects. The effect of these defects on the hysteresis curves was analyzed. The interaction of a single domain wall with a defect cluster was also investigated with this model. Furthermore, the simulation could be used to verify the dependence of the Rayleigh constant on the defect concentration, predicted by Boser [J. Appl. Phys. 62 (1987) 1344] theoretically and recently found to be valid for donor-doped lead zirconate titanate (PZT) thin films [Bolten et al., Appl. Phys. Lett. 77 (2000) 3830]. The simulation provided evidence for the existence of a defect-driven relaxation process in ferroelectrics similar to the relaxation found in heavily disturbed systems.
Thermal stability of nanocrystalline fcc and hcp Ni(Si) synthesized by mechanical alloying of Ni90Si10 (2001)

The thermal stability of nanocrystalline fcc and hcp Ni(Si), obtained by mechanical alloying of Ni90Si10, has been studied. The allotropic transformation from fcc to hcp Ni(Si) is accompanied by a volume expansion of 8.6% and is observed when fcc Ni(Si) reaches a critical crystallite size of 10nm. The hcp phase transforms to stable fcc Ni(Si) at 573K. It has been identified that the lattice distortion in nanometre-sized crystallites from the equilibrium configuration and the decrease in the interfacial energy with grain refinement act as self obstacles in controlling the grain growth of nanocrystalline materials.
Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria (2019)

These results suggest that apo-transferrin may have promise to suppress the emergence of antibiotic-resistant mutants when treating infections caused by Gram-negative bacteria.
Improved Synthesis of CMP-Sialates Using Enzymes from Frog Liver and Equine Submandibular Gland (1979)

An efficient method for the preparation of CMP-N-acetylneuraminic acid using crude or partially purified CTP:N-acylneuraminate cytidylyltransferase from equine submandibular gland or frog liver is described. The yield of the sugar nucleotide after purification by ion-exchange chromatography and gel filtration was 95%. The compound was studied by 360 MHz 1H NMR spectroscopy in addition to the usual chemical and physical analyses. The preparation of radioactive or unlabelled CMP 4-O-methyl-N-acetylneuraminic acid, which is not known to occur in nature, was achieved in 17% yield with the aid of the equine enzyme.
Why overlearned sequences are special: distinct neural networks for ordinal sequences (2012)

Several observations suggest that overlearned ordinal categories (e.g., letters, numbers, weekdays, months) are processed differently than non-ordinal categories in the brain. In synesthesia, for example, anomalous perceptual experiences are most often triggered by members of ordinal categories (Rich et al., 2005; Eagleman, 2009). In semantic dementia (SD), the processing of ordinal stimuli appears to be preserved relative to non-ordinal ones (Cappelletti et al., 2001). Moreover, ordinal stimuli often map onto unconscious spatial representations, as observed in the SNARC effect (Dehaene et al., 1993; Fias, 1996). At present, little is known about the neural representation of ordinal categories. Using functional neuroimaging, we show that words in ordinal categories are processed in a fronto-temporo-parietal network biased toward the right hemisphere. This differs from words in non-ordinal categories (such as names of furniture, animals, cars, and fruit), which show an expected bias toward the left hemisphere. Further, we find that increased predictability of stimulus order correlates with smaller regions of BOLD activation, a phenomenon we term prediction suppression. Our results provide new insights into the processing of ordinal stimuli, and suggest a new anatomical framework for understanding the patterns seen in synesthesia, unconscious spatial representation, and SD.
GENERAL SESSION (1991)

The biological behaviour of the endocrine-paracrine cells (EP ce-
The Lowest Approximation for Inelastic Acoustic Phonon Scattering Consideration in a Monte Carlo Procedure (1993)

Abstract A simple algorithm to account for acoustic scattering inelasticity in the Monte Carlo procedure is suggested. The temperature range is evaluated at which the proposed method is suitable. Good agreement of the computed results using the proposed algorithm with an analytical solution of the kinetic equation and the data obtained by other techniques is established.
Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones (2003)

A practical and environmentally friendly organocatalytic process for the synthesis of optically active highly substituted spiro[5,5]undecane-1,5,9-triones was achieved through the reaction of an aldehyde, an enone, and Meldrum's acid in the presence of a catalytic amount of chiral amino acid (see scheme). The Diels–Alder products were obtained as single diastereomers in excellent yields and enantiomeric excesses.
The time-triggered model of computation (2002)

The Time-Triggered (TT) model of computation is a model for the representation and analysis of the design of large hard real time systems. Central to this model is the concept of temporal accuracy of real time information. The TT model consists of four building blocks, interfaces that contain temporally accurate data, a communication subsystem that connects interfaces, a host computer that reads input data from interfaces and writes output data to interfaces and a transducer that transforms the information representation in the environment into the digital form of the interface and vice versa. These four building blocks can be used recursively to describe arbitrary large hard real time systems. The TT model separates cleanly the design of the interaction pattern among components from the design of the components themselves. It thus supports a compositional design. In the final section the TT model is compared to the client server model.
Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa (2019)

Two decades of research have uncovered the mechanism by which the complex of tissue factor (TF) and the plasma serine protease factor VIIa (FVIIa) mediates the initiation of blood coagulation. Membrane-anchored TF directly interacts with substrates and induces allosteric effects in the protease domain of FVIIa. These properties are also recapitulated by the soluble ectodomain of TF (sTF). At least two interdependent allosteric activation pathways originate at the FVIIa:sTF interface are proposed to enhance FVIIa activity upon sTF binding. Here, we sought to engineer an sTF-independent FVIIa variant by stabilizing both proposed pathways, with one pathway terminating at segment 215-217 in the activation domain and the other pathway terminating at the N terminus insertion site. To stabilize segment 215-217, we replaced the flexible 170 loop of FVIIa with the more rigid 170 loop from trypsin and combined it with an L163V substitution (FVIIa-VY T ). The FVIIa-VYT variant exhibited 60-fold higher amidolytic activity than FVIIa, and displayed similar FX activation and antithrombin inhibition kinetics to the FVIIa.sTF complex. The sTF-independent activity of FVIIa-VY T was partly mediated by an increase in the N terminus insertion and, as shown by X-ray crystallography, partly by Tyr-172 inserting into a cavity in the activation domain stabilizing the S1 substrate-binding pocket. The combination with L163V likely drove additional changes in a delicate hydrogen-bonding network that further stabilized S1-S3 sites. In summary, we report the first FVIIa variant that is catalytically independent of sTF and provide evidence supporting the existence of two TFmediated allosteric activation pathways. A. B.
Holography in museums (2011)

This paper discusses some aspects of holographic display techniques pertinent for museum applications. In particular, it revises the features and requirements for three-dimensional (3D) holographic displays, examines the practical use of holographic interferometry as an effective tool for non-destructive inspection of museum items, discusses holographic methods for high-density data storage and outlines how 3D images can be integrated into a large coverage area.
An implementation method for the discrete Kalman filter with applications to large-scale systems (1984)

An interesting implementation procedure is developed for use in a covariance propagation problem involving a discrete Kalman filter. Using a matrix continued fraction (MCF) method for the calculation of the covariance matrix, the final implementation requires one matrix inversion involving a sequence of controllability matrices, observability matrices, and an initial condition matrix. Using procedures as discussed by Mendel (1971), Bierman (973, 1977) Kaminski et al. (1971) and Carlson (1973), a numerical comparison in terms of computing time and computer storage is made between the approach developed here and the conventional method. This algorithm is intended to be used as an alternative method to implement the Kalman filter. For certain classes of large-scale systems, the MCF method provides both a reduction of computer time and computer storuge. An example is worked to illustrate the applicability of the approach presented here.
Measurement of D⁎±, D± and Ds± meson production cross sections in pp collisions at s=7 TeV with the ATLAS detector (2016)

The production of D⁎±, D± and Ds± charmed mesons has been measured with the ATLAS detector in pp collisions at s=7 TeV at the LHC, using data corresponding to an integrated luminosity of 280 nb−1. The charmed mesons have been reconstructed in the range of transverse momentum 3.5<pT(D)<100 GeV and pseudorapidity |η(D)|<2.1. The differential cross sections as a function of transverse momentum and pseudorapidity were measured for D⁎± and D± production. The next-to-leading-order QCD predictions are consistent with the data in the visible kinematic region within the large theoretical uncertainties. Using the visible D cross sections and an extrapolation to the full kinematic phase space, the strangeness-suppression factor in charm fragmentation, the fraction of charged non-strange D mesons produced in a vector state, and the total cross section of charm production at s=7 TeV were derived.
Rapid Molecular Genotyping and Clonal Complex Assignment of Staphylococcus aureus Isolates by PCR Coupled to Electrospray Ionization-Mass Spectrometry (2009)

We describe a high-throughput assay using PCR coupled to electrospray ionization-mass spectrometry (PCR/ESI-MS) to determine the genotypes of Staphylococcus aureus isolates. The primer sets used in the PCR/ESI-MS assay were designed to amplify the same genes analyzed in multilocus sequence typing (MLST). The method was used to identify the clonal complex and USA type of each isolate and is suitable for use in a clinical or public-health setting. The method was validated using a panel of diverse isolates from the Centers for Disease Control and Prevention that were previously characterized by MLST and pulsed-field gel electrophoresis (PFGE). Clinical isolates from two geographically distinct hospitals were characterized, and the clustering results were in agreement with those for repetitive-element PCR and PFGE. The PCR/ESI-MS method enables genotyping of over 180 samples of S. aureus per day in an automated fashion.