gebhart/patrepeval huggingface dataset:
Electron Paramagnetic Resonance of Bovine Superoxide Dismutase. (1981)

This thesis describes the design and construction of a system to record and analyse electron paramagnetic resonance data from single crystals, and presents the results obtained by applying this system to the study of the Cu(II) ion in bovine superoxide dismutase. The electron paramagnetic resonance (EPR) machine described was designed specifically for work with protein single crystals at 9.5 GHz. To achieve high sensitivity, the design incorporates a rectangular TE(,101) microwave resonant cavity. "Two circle" rotational freedom is provided by a magnet with a rotating base and a sample goniometer which incorporates a 72-tooth antibacklash wormwheel. A unique combination of hardware and "software" allows crystal axis alignment information obtained by X-ray diffraction precession photography to be used in orienting crystals for the EPR experiments. Since the X-ray diffraction camera sample mount is the EPR sample mount, the orientation of the crystal with respect to the magnetic field of the EPR experiment is known with a very high degree of accuracy. By using this system, EPR spectra have been obtained from crystals of bovine superoxide dismutase (BSD). Spectra have also been obtained from crystals of BSD containing isotopically pure ('65)Cu, and from crystals which have been reacted with cyanide (BSD + CN). To analyse the spectra, computer programs have been written which make use of an algorithm based on a second-order perturbation theory treatment of the spin Hamiltonian of Cu(II). These programs make use of interactive computer graphics to compare simulated crystal EPR spectra with the experimental data. Programs have also been written to simulate EPR spectra obtained from frozen solutions of BSD and BSD + CN, using the same computational techniques. The results of this detailed study of the EPR properties of the Cu(II)ion in BSD are interpreted in terms of the known crystallographicstructure of the protein. Specifically, the orientation of the principal(, )axes of the Cu(II) magnetic tensors (g and A) are described with respectto the coordinates of the atoms which make up the metal binding site of the protein. A shift in the direction and magnitude of g(,z) is observed upon binding of CN to the protein; this indicates that the active site may undergo a conformational change upon CN binding.
Low-loss Waveguides Fabricated in KGd(WO 4 ) 2 by High Repetition Rate Femtosecond Laser (2007)

We report formation of low-loss waveguides in KGd(WO4)2 with a focused high repetition-rate femtosecond laser. The guiding structures support both TE and TM polarized modes and show preservation of the crystal Raman activity.
Monitoring and mining GPS traces in transit space (2013)

Users of mass transit systems such as those of buses and trains normally rely on accurate route maps, stop locations, and service schedules when traveling. If the route map, service schedule, or stop location has errors it can reduce the transit agency's ridership. In this paper, the problem of deriving transit systems by mining raw GPS data is studied. Specifically, we propose and evaluate novel classification features with spatial and temporal clustering techniques that derive bus stop locations, route geometries, and service schedules from GPS data. Subsequently, manual and expensive field visits to record and annotate the initial or updated route geometries, transit stop locations, or service schedules is no longer required by transit agencies. This facilitates a massive reduction in cost for transit agencies. The effectiveness of the proposed algorithms is validated on the third largest public transit system in the United States.
A Neural Network for the Identification of Measured Helicopter Noise (1993)

The results of a preliminary study of the components of a novel acoustic helicopter identification system are described. The identification system uses the relationship between the amplitudes of the first eight harmonics in the main rotor noise spectrum to distinguish between helicopter types. Two classification algorithms are tested; a statistically optimal Bayes classifier, and a neural network adaptive classifier. The performance of these classifiers is tested using measured noise of three helicopters. The statistical classifier can correctly identify the helicopter an average of 67 percent of the time, while the neural network is correct an average of 65 percent of the time. These results indicate the need for additional study of the envelope of harmonic amplitudes as a component of a helicopter identification system. Issues concerning the implementation of the neural network classifier, such as training time and structure of the network, are discussed.
RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression (2019)

The main obstacle to develop effective therapies for patients with t-NEPC is the lack of understanding on how t-NEPC is developed. Our study not only identifies a previously unknown BHC80-2-MyD88 signaling pathway that plays an important role during t-NEPC development, but also provides a proof of principle that targeting this signal pathway may offer an avenue to treat t-NEPC.
Electrically Controllable Saturable Absorption in Hybrid Graphene-Silicon Waveguides (2015)

Electrical tunability of saturable absorption is demonstrated in a graphene/SOI hybrid waveguide. The saturation modulation depth is tunable between 0 and 2.2 dB (∼0–40% decrease of absorption at saturation), with saturation powers between ∼1.25–2.5 W.
An Efficiency Optimization Scheme for Bidirectional Inductive Power Transfer Systems (2014)

Unidirectional inductive power transfer systems allow loads to consume power, while bidirectional inductive power transfer (BIPT) systems are more suitable for loads requiring two-way power flow such as vehicle to grid applications with electric vehicles. Many attempts have been made to improve the performance of BIPT systems. In a typical BIPT system, the output power is controlled using the pickup converter phase shift angle, while the primary converter regulates the input current. This paper proposes an optimized phase-shift modulation strategy to minimize the coil losses of a series-series compensated BIPT system. In addition, a comprehensive study on the impact of power converters on the overall efficiency of the system is also presented. A closed-loop controller is proposed to optimize the overall efficiency of the BIPT system. Theoretical results are presented in comparison to both simulations and measurements of a 0.5 kW prototype to show the benefits of the proposed concept. Results convincingly demonstrate the applicability of the proposed system offering high efficiency over a wide range of output power.
MP41-04 URINARY CORRELATES OF PATHOLOGIC COMPLETE RESPONSE IN BLADDER CANCER PATIENTS RECEIVING NEOADJUVANT CHEMOTHERAPY (2018)

months, 343 (32.1%) recurrence was recorded. Of these, 213 (20.0%) recorded single site recurrence and 130 (12.2%) multiple site recurrence. Considering single site recurrence, 151 (14.2%), 18 (1.7%) and 44 (4.1%) were distant, urothelial or local recurrence, respectively. At univariable analyses, small cell variant was associated with an increased risk of overall recurrence when compared to urothelial recurrence (Hazard ratio [HR]: 2.58 (1.52-3.47), p: 0.01). Similar results were found at multivariable analyses (HR: 3.47 (1.58-7.61), p<0.001). Multiple mixed variants were associated to local recurrence (HR: 3.60 (1.18-10.94), p:0.02). No predictors were found considering urothelial or distant recurrences.
Universitätsbibliothek Kiel: Jahresbericht 2018 (2020)

Der Jahresbericht informiert über die wichtigsten Aktivitäten der Universitätsbibliothek Kiel und stellt ausgewählte Daten, Zahlen und Fakten zur Verfügung. Als wichtiger Eckpfeiler im Berichtswesen der Bibliothek beschreibt er unser vielfältiges Spektrum an Services und Projekten.
VLSI Algorithms and architectures for JPEG2000 (2006)

In this paper, we presented VLSI algorithms and architectures for JPEG2000. JPEG2000 is the new standard for image compression. We briefly described the core algorithms for JPEG2000 standard and its several features desirable in many interactive multimedia applications. The core compression algorithm has three major components - discrete wavelet transform (DWT), fractional bit plane coding (BPC), and context adaptive binary arithmetic coding. DWT and BPC are very computationally, as well as memory expensive operations. As a result, special purpose VLSI implementations of these algorithms are desirable for many devices to compress large size images in real time. Traditionally, the DWT is realized by convolution based finite impulse response (FIR) filtering techniques. However, Lifting based implementation of DWT is found to be computationally efficient and suitable for VLSI implementations. The basic principle behind the lifting based scheme is to decompose the finite impulse response filters in wavelet transform into a finite sequence of simple filtering steps. Lifting based DWT implementation have been recommended in JPEG2000 standard. Consequently, this has become an area of active research and several architectures have been proposed in recent years. In this paper, we reviewed some of the key lifting architectures suitable for VLSI implementation. The embedded block coding with optimized truncation (EBCOT) algorithm has been adopted for computation of BPC in JPEG2000. This algorithm is complex and inefficient to implement in a general purpose machine. We have described a special purpose architecture suitable for VLSI implementation of EBCOT algorithm. We also reviewed some elegant architectures in the literature which exploit the underlying data and computational parallelism inherent in the EBCOT algorithms. We also presented a top-level systems architecture for VLSI implementation of the JPEG2000 standard.
Characterization of cyanobacterial phycobilisomes in zwitterionic detergents (1979)

Properties of cyanobacterial phycobilisomes (from Synechococcus spp. 6301 and 6312 and Synechocystis sp. 6701) prepared in the presence of two different zwitterionic detergents were compared to those of phycobilisomes detached from membranes with the nonionic detergent Triton X-100 and then freed from Triton by sedimentation through high-salt sucrose density gradients. The absorption spectra, polypeptide composition, and ultrastructure of phycobilisomes were independent of the detergent used during the preparation. Phycobilisomes from certain cyanobacteria aggregated in the absence of detergent. Such aggregation was not seen in preparations containing zwitterionic detergents. Aggregation of phycobilisomes led to a partial quenching of their fluorescence. Electron microscopy showed the three types of phycobilisomes to have a hemi-disc appearance, although their detailed structures were quite different.
Carnitine Profile by Tandem Mass Spectrometry and Dialysis Patients (2019)

Tandem mass spectrometry has recently revealed the relationships between carnitine profile and dialysis patients' anemia, reduced physical function, and survival rate. Fatty acid and organic acid metabolism, which could previously only be evaluated qualitatively, can now be quantitatively assessed. Key Message: The applications of tandem mass spectrometry are expected to expand not only in the field of dialysis but also in clinical medicine in general.
Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals (2006)

Substantial evidence indicates that the locus ceruleus (LC)-norepinephrine (NE) projection system regulates behavioral state and state-dependent processing of sensory information. Tonic LC discharge (0.1-5.0 Hz) is correlated with levels of arousal and demonstrates an optimal firing rate during good performance in a sustained attention task. In addition, studies have shown that locally applied NE or LC stimulation can modulate the responsiveness of neurons, including those in the thalamus, to nonmonoaminergic synaptic inputs. Many recent investigations further indicate that within sensory relay circuits of the thalamus both general and specific features of sensory information are represented within the collective firing patterns of like-modality neurons. However, no studies have examined the impact of NE or LC output on the discharge properties of ensembles of functionally related cells in intact, conscious animals. Here, we provide evidence linking LC neuronal discharge and NE efflux with LC-mediated modulation of single-neuron and neuronal ensemble representations of sensory stimuli in the ventral posteriomedial thalamus of waking rats. As such, the current study provides evidence that output from the LC across a physiologic range modulates single thalamic neuron responsiveness to synaptic input and representation of sensory information across ensembles of thalamic neurons in a manner that is consistent with the well documented actions of LC output on cognition.
Long‐term Animal Survival with an Implantable Axial Flow Pump as a Left Ventricular Assist Device (1996)

We are developing an axial flow blood pump with Nimbus Inc. (AxiPump). For in vivo evaluation the AxiPump has been used as a left ventricular assist device with a left ventricular and descending aorta cannulation and implantation in a small pocket on the left lateral abdominal wall just posterior to the costal margin. Electrical and flow probe leads exit the body transcutaneously. A purge line that delivers the purge fluid for lubrication of the seal between the rotor and stator bodies in the purge fluid bearing system is tunneled with the other leads. Following acute animal studies, 3 animals have been supported for over 1 month with this AxiPump system. All laboratory results were within normal limits except during a recovery period from surgical damage. Hemolysis was not a serious problem. In the first case, the purge system failed at 28 days, and in the second and third cases, the nonpurge bearing system worked well for 57 and 52 days, respectively. Bearings are still under development in this kind of pump. However, this success encourages us to improve the AxiPump as a long-term assist device.
Detection of GroEL in activated sludge: a model for detection of system stress (2000)

GroEL is a ubiquitous constitutively synthesized protein that is also stress inducible. Activated sludge, which is a standard biological process used in wastewater treatment systems, is made up of a diverse microbial consortium. The synthesis of GroEL in activated sludge was significantly induced after heat (42 degrees C) shock. The increased level of GroEL expression was shown to be due to de novo protein synthesis. We have demonstrated a method which shows that stress proteins can be detected in activated sludge, and propose their use as specific indicators of system stress.
Robust Object-Based Watermarking Using Feature Matching (2008)

We present a robust object-based watermarking algorithm using the scale-invariant feature transform (SIFT) in conjunction with a data embedding method based on Discrete Cosine Transform (DCT). The message is embedded in the DCT domain of randomly generated blocks in the selected object region. To recognize the object region after being distorted, its SIFT features are registered in advance. In the detection scheme, we extract SIFT features from the distorted image and match them with the registered ones. Then we recover the distorted object region based on the transformation parameters obtained from the matching result using SIFT, and the watermarked message can be detected. Experimental results demonstrated that our proposed algorithm is very robust to distortions such as JPEG compression, scaling, rotation, shearing, aspect ratio change, and image filtering.
Antibacterial Narrow‐Band‐Gap Conjugated Oligoelectrolytes with High Photothermal Conversion Efficiency (2017)

Two conjugated oligoelectrolytes (COEs), WMG1 and WMG2, were designed with the goal of achieving near infrared absorption and high photothermal conversion efficiency. Specifically, electron-rich thiophene and electron-poor benzo[1,2-c:4,5-c']bis[1,2,5]thiadiazole subunits were introduced into the conjugated core to modulate the optical gap and to reduce the fluorescence emission efficiency. WMG1 and WMG2 show absorption maxima at around 800 nm, which favors tissue penetration. Although relatively small in size, WMG1 and WMG2 exhibit photothermal conversion efficiencies of circa 60 % and 54 %, respectively. WMG1 shows dark toxicity to the Gram positive bacterium B. subtilis and good photothermal killing efficiency toward both B. subtilis and Gram negative E. coli, features that demonstrate the promising potential of the COE molecular design for photothermal applications.
Optimal Gossip with Direct Addressing (2014)

Gossip algorithms spread information by having nodes repeatedly forward information to a few random contacts. By their very nature, gossip algorithms tend to be distributed and fault tolerant. If done right, they can also be fast and message-efficient. A common model for gossip communication is the random phone call model, in which in each synchronous round each node can PUSH or PULL information to or from a random other node. For example, Karp et al. [FOCS 2000] gave algorithms in this model that spread a message to all nodes in $Θ(\log n)$ rounds while sending only $O(\log \log n)$ messages per node on average. Recently, Avin and Elsässer [DISC 2013], studied the random phone call model with the natural and commonly used assumption of direct addressing. Direct addressing allows nodes to directly contact nodes whose ID (e.g., IP address) was learned before. They show that in this setting, one can "break the $\log n$ barrier" and achieve a gossip algorithm running in $O(\sqrt{\log n})$ rounds, albeit while using $O(\sqrt{\log n})$ messages per node. We study the same model and give a simple gossip algorithm which spreads a message in only $O(\log \log n)$ rounds. We also prove a matching $Ω(\log \log n)$ lower bound which shows that this running time is best possible. In particular we show that any gossip algorithm takes with high probability at least $0.99 \log \log n$ rounds to terminate. Lastly, our algorithm can be tweaked to send only $O(1)$ messages per node on average with only $O(\log n)$ bits per message. Our algorithm therefore simultaneously achieves the optimal round-, message-, and bit-complexity for this setting. As all prior gossip algorithms, our algorithm is also robust against failures. In particular, if in the beginning an oblivious adversary fails any $F$ nodes our algorithm still, with high probability, informs all but $o(F)$ surviving nodes.
An investigation into momentum and temperature fields of a meso-scale synthetic jet (2014)

Thermal management has become a critical part of advanced micro and nano electronics systems due to high heat transfer rates. More constraints such as compactness, small footprint area, lightweight, high reliability, easy-access and low cost are exposed to thermal engineers. Advanced electronic systems such as laptops, tablets, smart phones and slim TV systems carry those challenging thermal needs. For these devices, smaller thermal real estates with higher heat fluxes than ever have created issues that current thermal technologies cannot meet those needs easily. Therefore, innovative cooling techniques are necessary to fulfill these aggressive thermal demands. Synthetic jets have been studied as a promising technology to satisfy the thermal needs of such tight electronics devices. The effect of nozzle-to-surface distance for a synthetic jet on its cooling performance has neither been studied extensively nor been well-understood. In a few available experimental studies, it was reported that synthetic jet performance is very sensitive to this distance and when the jet gets closer to the hot surface its performance degrades. Therefore, a computational study has been performed to understand the flow physics of a small-scale synthetic jet for a jet-to-surface spacing of H/D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</sub> =5. Spatial discretization is implemented via a second order upwind scheme and a second order implicit scheme is used for temporal discretization to ensure stability. It is found that pulsating flow at the nozzle exit generates vortices and these vortices seem to have minimal effect on the target surface profiles. Local surface pressure, velocity, turbulence profiles and heat transfer coefficient distributions are determined, then the effects of jet frequency as well as near-wall vortices are discussed.
Three‐dimensional analysis of the tibial resection plane relative to the arthritic tibial plateau in total knee arthroplasty (2017)

Use of this analysis on a larger population can quantify the effectiveness of the tibial resection for correcting pathologies, potentially reduce imprecisions in the surgical technique, and enable development of instrumentation that reduces the risk of resection recuts. The kinematic alignment technique consistently corrects varus deformities.
LASER THERAPY FOR MULTIPLE BlLlARY PAPILLOMATOSIS VIA CHOLEDOCHOSCOPY (1997)

Laser therapy via choledochoscopy is a satisfactory mode of treatment for multiple biliary papillomatosis. It enables complete and precise ablation of the tumour which certainly changes the prognosis of this condition.
Energy Modeling of a Lead-Acid Battery within Hybrid Wind/Photovoltaic Systems (2003)

International audience
The asymptotic behaviour and a near linear time algorithm for isometry\n invariants of periodic sets (2020)

The fundamental model of a periodic structure is a periodic point set up to\nrigid motion or isometry. Our recent paper in SoCG 2021 defined isometry\ninvariants (density functions), which are complete in general position and\ncontinuous under perturbations. This work introduces much faster isometry\ninvariants (average minimum distances), which are also continuous and\ndistinguish some sets that have identical density functions. We explicitly\ndescribe the asymptotic behaviour of the new invariants for a wide class of\nsets including non-periodic. The proposed near linear time algorithm processed\na dataset of hundreds of thousands of real structures in a few hours on a\nmodest desktop.\n
Supplemental Table 1. Thirty-nine cell lines used in combination screen. from An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies (2023)

&lt;p&gt;RAS mutation/signature does not predict response to mTOR/Wee1 combination.&lt;/p&gt;
A possible mechanism for visible light‐induced wound healing (2008)

Visible light at high intensity can kill bacteria in infected wounds. Thus, illumination of infected wounds with intense visible light, prior to low intensity illumination for stimulating wound closure, may reduce infection and promote healing.
Vertical transition with elastomeric connectors (2003)

Several prototypes of vertical transitions with the application of Shin-Etsu elastomeric connectors are designed and tested. The insertion loss of a holder with an elastomeric connector coupling two ground coplanar lines, spaced at distance 5 mm, is lower than 0.5 dB at lower frequencies only (below 2 GHz). A transition with properly separated elastomeric connectors is appropriate up to 4-5 GHz. And a hybrid transition consisting of a coaxial line terminated with an elastomeric connector can operate up-to Ku-band.
Contrast enhanced nanoCT for volumetric analyses of in vitro manufactured tissue-engineered bone constructs: a soft tissue case study (2013)

sponsorship: GK and LG acknowledge support by the European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013)/ERC grant agreement n°279100. MS is supported by a Ph.D. grant of the Agency for Innovation by Science and Technology (IWT/ 111457). IP is funded by the ENDEAVOUR project G.0982.11N of the Research Foundation Flanders (FWO Vlaanderen). This work is part of Prometheus, the Leuven Research & Development Division of Skeletal Tissue Engineering of the Katholieke Universiteit Leuven: www.kuleuven.be/prometheus