gebhart/patrepeval huggingface dataset:
Abstract 259: Role of Connexin 43 in Human Bone Marrow Derived Mesenchymal Stem Cell Cardiac Integration and Cardiac Stem cell Niche Formation. (2013)

Introduction: Bone marrow-derived mesenchymal stem cells (MSCs) and cardiac progenitor cells (CPCs) have been used successfully as a cell-based approach for cardiac regeneration after myocardial infarction. While MSCs and CPCs are effective, in part due to differentiation, paracrine effect, and integration into the heart, the mechanism underlying these effects remains controversial. Objective: We hypothesized that functional connexin 43 (Cx43) gap junctions are crucial for MSC and CPCs interaction and integration into cardiac tissue and cardiac stem cell niche formation. Methods and Results: Human MSCs were co-cultured with neonatal rat ventricular cardiomyocytes (NRVMs). The ability of MSCs to form gap junctions was modulated using lentiviral constructs to either knockdown (Cx43KD) or overexpress (Cx43OE) Cx43. Co-culture of Cx43OE or control MSCs with NRVMs led to the formation of beating, three-dimensional tubes whereas Cx43KD MSCs failed to form tubes (n=5, p&lt;0.05). Furthermore, we replicated the cardiac stem cell niche by combining human CPCs and MSCs in an in vitro model (the same lentiviral constructs were used). As a result, Cx43 expressing MSCs and CPCs formed organotypic three-dimensional structures similar to human MSCs and NRVMs, whereas the lack of Cx43 significantly affected the structure formation (n=6, p&lt;0.05). Cx43KD significantly increased proliferation (n=5, p&lt;0.05) and changed culture phenotype (n=4, p&lt;0.05) of MSCs or CPCs cultured separately. The angiogenic tube length, assessed by a Matrigel assay in vitro, was significantly reduced in MSCs and HUVEC Cx43 KD groups compared to control (n=5, p&lt;0.05). The change/onset of endothelial (KDR, PECAM-1, VE-cadherin), and cardiomyocyte (Nkx2.5, Gata4, Troponin I, Na+ channel, K+ channel, Ca2+ channel, Na+-Ca2+ exchanger) gene expression was investigated in co-culture of MSCs and CPCs. Only voltage ion channel gene expression was upregulated in control and Cx43OE groups by co-culture (n=5, p&lt;0.05), but not affected in Cx43KD group. Conclusion: These findings reveal that cell−cell contact mediated by Cx43 gap junctions enables MSCs to interact with CPCs, integrate and reconstitute cardiac stem cell niches.
Die seitengetrennte Bestimmung des effektiven Nierenplasmastroms mit Radioisotopen (1971)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42 (2017)

A reliable blood-based assay is required to properly diagnose and monitor Alzheimer’s disease (AD). Many attempts have been made to develop such a diagnostic tool by measuring amyloid-β oligomers (AβOs) in the blood, but none have been successful in terms of method reliability. We present a multimer detection system (MDS), initially developed for the detection of prion oligomers in the blood, to detect AβOs. To characterize Aβ in the blood, plasma was spiked with synthetic amyloid-β (Aβ) and incubated over time. Then, the MDS was used to monitor the dynamic changes of AβO levels in the plasma. Increasing concentrations of AβOs were observed in the plasma of patients with AD but not in the plasma of normal control subjects. The plasma from patients with AD (n = 27) was differentiated from that of the age-matched normal control subjects (n = 144) with a sensitivity of 83.3% and a specificity of 90.0%. Synthetic Aβ spiked into the blood plasma of patients with AD, but that of not elderly normal control subjects, induced dynamic changes in the formation of AβOs over time. AβOs were detected by the MDS, which is a useful blood-based assay with high sensitivity and specificity for AD diagnosis.
Ultra-fast Electromagnetic Transient Model of the Modular Multilevel Converter for HVDC Studies (2016)

This paper introduces a very fast electromagnetic transient (EMT) simulation model for the HVDC modular multi-level converter (MMC) that maintains the identity of each switching level, but achieves computation speeds comparable to much simplified averaged models. In contrast with previously developed fast MMC simulation models, this model achieves its speedup by using a special time-varying Thevenin equivalent based algorithm that uses the A-stable Backward Euler (BE) integration method. The approach assumes the switch's “ON” condition as a conduction resistance, whereas the “OFF” condition is modeled by an ideal open circuit. The approach was compared with a full detailed simulation (no simplifications), and showed negligible loss in accuracy and yet had a much reduced computational time, comparable with the much less accurate averaged-value models (AVM).
Multivariate partial fraction expansion (2009)

The Derive computer-algebra program has Expand as one of the menu choices: The user is prompted for successively less main expansion variables, which can be all of the variables or any proper subset. It is clear how to proceed when the expression is a polynomial: Fully distribute with respect to all expansion variables, but collect as coefficient polynomials all terms that share the same exponents for the expansion variables. Derive uses a partially factored form, so the collected coefficient polynomials can be fortuitously partially factored. For rational expressions the expand function does partial fraction expansion because it is the most useful kind of rational expansion. However, most other computer algebra systems and examples in the literature focus on partial fraction expansion with respect to only one variable, where any other variables are considered mere parameters. For consistency with multivariate polynomial expansion, we wanted a useful and well-defined meaning for multivariate partial fraction expansion. This paper provides such a definition and a corresponding algorithm.
4-Hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one Induces Mitochondrial Dysfunction and Apoptosis upon Its Intracellular Oxidation (2004)

We investigated the mechanism of cell death induced by a furoquinolinone derivative, namely, 4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HOFQ), in the dark. Mitochondrial depolarization was found to be a causative event in HOFQ-induced apoptosis that was blunted either by replacing the 4-hydroxymethyl group with a methyl one, or by 4-methylpyrazole, an inhibitor of alcohol dehydrogenase (ADH). In vitro enzymatic assay demonstrated that HOFQ is a substrate of ADH. In isolated mitochondria HOFQ was without effect, whereas in the presence of ADH and NAD(+) it caused the opening of the permeability transition pore, indicating that HOFQ-oxidized products affect mitochondrial function directly. Finally, an analogue bearing the formyl group at the C-4 position mimicked all the effects exerted by HOFQ. In conclusion, these results suggest that the direct action on mitochondria of HOFQ-oxidized products are responsible for their cytotoxicity, which might be exacerbated, but hardly determined, by photodynamic action and/or binding to DNA.
Feasibility of Radioimmunotherapy of Experimental Pneumococcal Infection (2004)

Streptococcus pneumoniae is an important cause of community-acquired pneumonia, meningitis, and bacteremia. The problem of pneumococcal disease is exacerbated by increasing drug resistance. Furthermore, patients with impaired immunity are at high risk for invasive pneumococcal infections. Thus, there is an urgent need for new approaches to antimicrobial therapy. Antibody therapies take advantage of the specificity and high affinity of the antigen-antibody interaction to deliver antibacterial compounds to a site of infection in the form of naked or conjugated antibodies. We have recently established that radioimmunotherapy (RIT) can be used to treat experimental fungal infections in mice. In the present study, we investigated the feasibility of applying a RIT approach to the treatment of S. pneumoniae infection by evaluating the susceptibility of S. pneumoniae to radiolabeled antibody in vitro and in an animal infection model. For the specific antibody carrier, we used human monoclonal antibody D11, which binds to pneumococcal capsular polysaccharide 8. We have selected the alpha particle emitter (213)Bi as the radionuclide for conjugation to the antibody. Incubation of serotype 8 S. pneumoniae with (213)Bi-D11 resulted in dose-dependent killing of bacteria. RIT of S. pneumoniae infection in C57BL/6 mice showed that 60% more mice survived in the (213)Bi-D11-treated group (80 micro Ci) than in the untreated group (P < 0.01). The treatment did not cause hematological toxicity, as demonstrated by platelet counts. This feasibility study establishes that RIT can be applied to the treatment of bacterial infections.
An optically efficient full-color reflective display with an electrochromic device and color production units (2019)

In this paper, we report a full-color reflective display device by combining reflective electrochromic device (ECD) and different color production units (conventional color filter (CF) and transmittance controllable electrochromic color filter (TCECF)). A full-color reflective device with TCECF showed an excellent diffuse reflectance of 47.2% in the white state owing to the high transmittance of TCECF in the bleached state than that of CF (19.5%). This device structure can easily provide various colors with high brightness and saturation with a broad grayscale. Particularly, in the colored state, TCECF and CF-based full-color reflective device displayed color coordinates of (0.59, 0.34), (0.31, 0.66), (0.24, 0.30) and (0.65, 0.33), (0.27, 0.61), (0.15, 0.06), for red, green and blue, respectively, and alongside also exhibited color gamut of 36.8% (for TCECF) and 73.1% (for CF) for full color reflective devices.
Predictive Factors for Response and Progression after Treatment with Rituximab in Previously Untreated Patients with Waldenstrom’s Macroglobulinemia (WM). (2005)

Abstract Introduction: Rituximab is an active agent for the treatment of WM. However many patients do not respond to this agent and several others develop secondary resistance. The purpose of this study was to identify clinical and laboratory parameters which could predict a higher likelihood of benefit in previously untreated WM patients who received treatment with rituximab. Patients and methods: We evaluated clinical and laboratory characteristics of 35 patients with WM who received primary treatment with single agent rituximab. We correlated these characteristics with response to treatment and time to progression. Results: Between 8/98 and 12/03, 35 WM patients, median age 68 (range 39–90), 24 male, received primary treatment with extended rituximab as previously described (Dimopoulos et al, JCO 2002 and Treon et al, Ann Oncol 2005). Anemia (Hgb&amp;lt;10g/dL) was present in 55%, thrombocytopenia (PLT&amp;lt;100,000/mm3) in 31%, lymphadenopathy in 40%, splenomegaly, hyperviscosity and B-symptoms were present in 17% of the patients each. 43% of the patients had M-peak levels 4gr/dL, 37% had albumin &amp;lt;3.5g/dL and 56% had 2 microglobulin &amp;gt;3,5mg/dL. Fifteen patients (43%) achieved at least 50% reduction of M-peak and of tumor infiltrates at all involved sites. Patients with Hg10 g/dL and monoclonal kappa light chain had a significantly higher probability to respond [65% vs 22% (pvalue 0.01) and 50% vs 10 % (p value 0,037) respectively]. Patients with higher albumin and lower serum M-peak levels had also a higher frequency of response (p=0,15 and 0,09 respectively). After a median follow-up of 43 months, 19 patients have progressed, (5 responders and 14 non responders) with a median PFS of 23,6 months for the whole patient population and not reached for the responders (75% without progression at 26 months). In the univariate analysis the most important factor predicting longer PFS was hemoglobin 10gr/dL (median 57,8 vs 5,4 months). Other factors associated with longer PFS was albumin 3,5gr/L (median 25,5 vs 5,3 months), serum M-peak &amp;lt;4gr/L (48 vs 6,2), absence of hyperviscosity (23 vs 3,5) and presence of k light chain (25,4 vs 5,1). Conclusion: Our analysis which included a large number of patients with long-term follow-up indicates that primary treatment with rituximab is associated with objective response in 43% of patients with WM and with a median PFS of 2 years. Patients most likely to benefit from rituximab include those without significant anemia, with k light chain, with lower levels of M-peak and with higher levels of albumin.
Measurements of the correlation between plasma bubble dynbamics and electron trapping in a laser wakefield accelerator (2010)

Summary form only given. Generation of conically emitted second harmonic radiation has recently been observed in a laser wakefield accelerator experiment at the U.S. Naval Research Laboratory. This second harmonic is the result of frequency mixing within the sheath surrounding a fully cavitated plasma region, "plasma bubble," created by the pondermotive force of a laser. Using this second harmonic signature, we have indirectly studied the dynamics of a plasma bubble. It has been observed that the plasma bubble dynamics are strongly correlated to the generation of electrons. Specifically, the onset of the bubble is connected to the generation of off-axis electrons, while forward accelerated electrons have been observed when the conical distribution of second harmonic is broken, signifying the disruption of the plasma bubble. Further results on bubble dynamics and its connection to electron beam production will be presented.
Biotic elicitation as a tool to improve strawberry and raspberry extract potential on metabolic syndrome‐related enzymes in vitro (2018)

It is good to include these two fruits in the diet because they improve the activity of metabolic syndrome-related enzymes. Applying either strain during plant growth modifies the bioactive profile of the plants, improving the effects of the fruit extracts on human health. © 2018 Society of Chemical Industry.
[Papillomavirus infection in a woman with cervix dysplasia]. (1998)

Les examens cytologiques des frottis cervicovaginaux de Madame H.M., 38 ans, realises au cours de ces dernieres annees, ont mis en evidence des lesions de type Ascus (atypies malpighiennes de signification indeterminee). Madame H.M. est vue en consultation de gynecologie pour un controle en decembre 1997. Ses frottis sont anormaux avec un aspect de lesion malpighienne de haut grade selon la classification de Bethesda. La colposcopie est douteuse. La biopsie du col presente des lesions intraepitheliales de haut grade (CIN 2 ou dysplasie moderee et focalement CIN 3 ou dysplasie severe) ; il n'y a pas de signe de micro-invasion sur les differents plans realises. Un bilan virologique est effectue par la recherche d'ADN de papillomavirus (HPV), dans un prelevement cervical, a l'aide de la technique d'hybridation Hybrid Capture® (Digene) en tube. Les HPV retrouves correspondent a des HPV a risque eleve. Une conisation a l'anse diathermique est alors realisee en fevrier 1998 ; l'examen histologique de la piece operatoire revele une dysplasie de haut grade avec un debut de micro-invasion. En regard des resultats de ces examens, une hysterectomie avec conservation des ovaires sera pratiquee prochainement.
Magnetorheological Jet (MR JetTM) Finishing Technology (2005)

Conformal (or freeform) and steep concave optics are important classes of optics that are difficult to finish using conventional techniques due to mechanical interferences and steep local slopes. One suitable way to polish these classes of optics is by using a jet of abrasive/fluid mixture. The energy required for polishing may be supplied by the radial spread of a liquid jet, which impinges a surface to be polished. Such fluid flow may generate sufficient surface shear stress to provide material removal in the regime of chemical mechanical polishing. Once translated into a polishing technique, this unique tool may resolve a challenging problem of finishing steep concave surfaces and cavities. A fundamental property of a fluid jet is that it begins to lose its coherence as the jet exits a nozzle. This is due to a combination of abruptly imposed longitudinal and lateral pressure gradients, surface tension forces, and aerodynamic disturbance. This results in instability of the flow over the impact zone and consequently polishing spot instability. To be utilized in deterministic high precision finishing of remote objects, a stable, relatively high-speed, low viscosity fluid jet, which remains collimated and coherent before it impinges the surface to be polished, is required. A method of jet stabilization has been proposed, developed, and demonstrated whereby the round jet of magnetorheological fluid is magnetized by an axial magnetic field when it flows out of the nozzle. It has been experimentally shown that a magnetically stabilized round jet of magnetorheological (MR) polishing fluid generates a reproducible material removal function (polishing spot) at a distance of several tens of centimeters from the nozzle. The interferometrically derived distribution of material removal for an axisymmetric MR Jet™ , which impinges normal to a plane glass surface, coincides well with the radial distribution of rate of work calculated using computational fluid dynamics (CFD) modeling. Polishing results support the assertion that the MR Jet finishing process may produce high precision surfaces on glass and single crystals. The technology is most attractive for the finishing of complex shapes like freeform optics, steep concaves, and cavities.
Spectroscopic light scattering for real-time measurements of thin film and surface evolution (1998)

We describe a light scattering technique for measuring the real-time evolution of thin film and surface morphology. By using spectroscopic detection, the technique requires no motion of the sample during the measurement, which makes it compatible with many processing geometries. Results from the growth of strained heteroepitaxial layers of SixGe1−x on Si(001) are presented to demonstrate the technique.
Recent Progress in the Surface Science Approach to Hydrodesulfurization Catalyst Development. (2000)

For the purpose of developing high performance hydrodesulfurization catalyst, increased numbers of work, based on precise analysis of catalyst active site structure using model support technique, have been carried out. Among those, we introduce following very attractive works. i.e. structural analysis of MoS2 clusters in atomic level by SPM, precise analysis of sulfidation mechanism by XPS, and study of the effect of support on the orientation of MoS2 clusters by HRTEM. New high performance catalysts are expected to be developed thorough these approach of surface science.
A 5 GHz floating point multiply-accumulator in 90 nm dual V/sub T/ CMOS (2003)

A 32 b single-cycle floating point accumulator that uses base 32 and carry-save format with delayed addition is described. Combined algorithmic, logic and circuit techniques enable multiply-accumulate operation at 5 GHz. In a 90 nm 7M dual-V/sub T/ CMOS process, the 2 mm/sup 2/ prototype contains 230K transistors and dissipates 1.2 W at 5 GHz, 1.2 V and 25/spl deg/C.
ChemInform Abstract: NEW SYNTHESIS AND ASSIGNMENT OF ABSOLUTE CONFIGURATION OF ENANTIOMERS OF O,S‐DIMETHYL PHOSPHORODITHIOATE (1980)

Abstract Das durch Kondensation des P‐chlorids (I) mit (S)‐ α‐Methylbenzylamin (II) gebildete (S)‐P‐amid (III) (Ausb. 74%) wird durch Behandlung mit einem Überschuß an Methyliodid in ein Gemisch zweier P‐enantiomerer Diastereomeren von (IV) (ca.
Abstract 16244: Survival, Reintervention, and Pulmonary Vascular Status After Stage II Palliation for Neonate with Hypoplastic Left Heart Syndrome: Hybrid vs. Norwood Strategies (2011)

BACKGROUND: Our previous study showed equivalent survival and pulmonary artery (PA) growth after Stage I palliation between infants with hypoplastic left heart syndrome (HLHS) palliated with a Norw...
Tissue-Specific Roles of NKT Cells in Tumor Immunity (2018)

NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-classical class-I-like molecule, rather than peptides presented by conventional MHC molecules. Type I NKT cells use a semi-invariant T cell receptor and almost all recognize a common prototype lipid, α-galactosylceramide (α-GalCer). Type II NKT cells are any lipid-specific CD1d-restricted T cells that use other receptors and generally don't recognize α-GalCer. They play important regulatory roles in immunity, including tumor immunity. In contrast to type I NKT cells that most have found to promote antitumor immunity, type II NKT cells suppress tumor immunity and the two subsets cross-regulate each other, forming an immunoregulatory axis. They also can promote other regulatory cells including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and can induce MDSCs to secrete TGF-β, one of the most immunosuppressive cytokines known. In some tumors, both Tregs and type II NKT cells can suppress immunosurveillance, and the balance between these is determined by a type I NKT cell. We have also seen that regulation of tumor immunity can depend on the tissue microenvironment, so the same tumor in the same animal in different tissues may be regulated by different cells, such as type II NKT cells in the lung vs Tregs in the skin. Also, the effector T cells that protect those sites when Tregs are removed do not always act between tissues even in the same animal. Thus, metastases may require different immunotherapy from primary tumors. Newly improved sulfatide-CD1d tetramers are starting to allow better characterization of the elusive type II NKT cells to better understand their function and control it to overcome immunosuppression.
Fiber Formation by Highly CO2‐Soluble Bisureas Containing Peracetylated Carbohydrate Groups (2007)

Like dissolves like: Bisureas containing environmentally benign CO2-philic groups derived from peracetylated gluconic acid dissolve in supercritical CO2 at 298 K and 62 MPa. Upon depressurization of the CO2, the initially powdery bisureas (left image) form microfibrillar foams (right image). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604844_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Are my Children Old Enough to Read these Books? Age Suitability Analysis (2011)

In general, books are not appropriate for all ages, so the aim of this work was to find an effective method of representing the age suitability of textual documents, making use of automatic analysis and visualization. Interviews with experts identified possible aspects of a text (such as ’is it hard to read?’) and a set of features were devised (such as linguistic complexity, story complexity, genre) which combine to characterize these age related aspects. In order to measure these properties, we map a set of text features onto each one. An evaluation of the measures, using Amazon Mechanical Turk, showed promising results. Finally, the set features are visualized in our age-suitability tool, which gives the user the possibility to explore the results, supporting transparency and traceability as well as the opportunity to deal with the limitations of automatic methods and computability issues.
Graphene-Based Quantum Hall Effect Infrared Photodetector Operating at liquid Nitrogen temperatures. (2011)

at liquid Nitrogen temperatures Nikolai G. Kalugin, Lei Jing, Wenzhong Bao, Lee Wickey, Christopher Del Barga, Mekan Ovezmyradov, Eric A. Shaner, and Chun Ning Lau Materials Engineering Department, New Mexico Tech, Socorro, New Mexico 87801, USA Physics Department, University of California-Riverside, Riverside California 92521, USA Center for Integrated Nanotechnologies and Sandia National Laboratories, Albuquerque, New Mexico 87185, USA