gebhart/patrepeval huggingface dataset:
Homeotropic reverse-mode polymer-liquid crystal device (1997)

We have proposed a new type of reverse-mode polymer-liquid crystal device: homeotropic reverse-mode polymer-liquid crystal (HRPLC). This device consists of a liquid crystal with a dielectric constant having negative anisotropy and a pair of glass plates covered with a homeotropic alignment layer. The HRPLC’s operation is the reverse of the usual; i.e., it is clear when no voltage is applied and opaque under applied voltage. We have confirmed that the HRPLC operates well in reverse mode and have studied the dependence of its properties on liquid crystal material, curing process, and cell thickness. Experimental results indicate the HRPLC has a 30:1 contrast ratio over an operating voltage range of 0–11 V. In special fabrication conditions, the transmittance–voltage curve of the HRPLC drops to a minimum at a certain voltage level and begins to increase at that point. We have proposed a model to explain this result.
Quadrupolar (donor)2acceptor-acid chromophores for dye-sensitized solar cells: influence of the core acceptor (2014)

A series of four quadrupolar (Donor)2Acceptor-acid (D2A) sensitizers, based on two acceptor cores (dibenzophenazine (DBP) or dithienophenazine (DTP)), were synthesized and their optoelectronic and photovoltaic properties were investigated. 4-Hexyl-thien-2-yl groups were employed as donor units, to produce regioisomers depending on their connecting position to the core. This architectural design leads to the investigation of the structure–property relationships of the dyes, both in solution and upon integration in dye-sensitized solar cells (DSSCs). Within sets of regioisomers, frontier orbital levels and absorption properties differed, but the photovoltaic performances of the DSSCs were similar. When examining the effect of the core, the electronic properties (absorbance, LUMO level) predicted a more favourable electron injection for the DTP systems. However, the open circuit voltages are ∼100 mV greater for the DBP systems.
Ps-Code: A New Code for Improved Degraded Mode Read and Write Performance of RAID Systems (2016)

The newer storage systems often have to deal with multiple disk failures. Thus, RAID (Redundant Array of Independent Disk) is becoming increasingly important for two primary benefits: (1) high read performance and (2) robust fault tolerance. In addition, the recent RAID codes achieve better IO performance by using only XORs (optimal computational complexity) to compute parities. However, this achieved optimal computational complexity limits the further IO performance improvement. In this paper, we are proposing a new code called PS-code (Parity Stripe code) that employs improved Cauchy Reed Solomon codes for computing the parity to further improve write and degraded mode read performance. Furthermore, we extend the novelty by reducing the number of writes required for updating the parity. We simulated the PS-code in the DiskSim environment and devised a new metric called multi- block access complexity to perform an improved evaluation of the performance of the PS-code on workloads that represent real life scenario such as multi-block updates. Also, the experimental results demonstrate that the PS-code, on average, achieves 66%-86% better write performance and achieves 8.9%-23.6% higher degraded-mode read performance compared to previous works including P-code, RDP code, X-code, and HV-code. Finally, the comparison between the vertical and horizontal codes demonstrates that the vertical codes have better read performance than the horizontal codes in most cases.
Measurements of forces involved in vesicle adhesion using freeze-fracture electron microscopy (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurements of forces involved in vesicle adhesion using freeze-fracture electron microscopyStuart M. Bailey, Shivkumar Chiruvolu, Jacob N. Israelachvili, and Joseph A. N. ZasadzinskiCite this: Langmuir 1990, 6, 7, 1326–1329Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/la00097a024https://doi.org/10.1021/la00097a024research-articleACS PublicationsRequest reuse permissionsArticle Views297Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation (2017)

<i>Monkeypox virus</i> (MPXV) is a human pathogen that is a member of the <i>Orthopoxvirus</i> genus, which includes <i>Vaccinia virus</i> and <i>Variola virus</i> (the causative agent of smallpox). Human monkeypox is considered an emerging zoonotic infectious disease. To identify host factors required for MPXV infection, we performed a genome-wide insertional mutagenesis screen in human haploid cells. The screen revealed several candidate genes, including those involved in Golgi trafficking, glycosaminoglycan biosynthesis, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis. We validated the role of a set of vacuolar protein sorting (VPS) genes during infection, VPS51 to VPS54 (VPS51-54), which comprise the Golgi-associated retrograde protein (GARP) complex. The GARP complex is a tethering complex involved in retrograde transport of endosomes to the <i>trans</i>-Golgi apparatus. Our data demonstrate that VPS52 and VPS54 were dispensable for mature virion (MV) production but were required for extracellular virus (EV) formation. For comparison, a known antiviral compound, ST-246, was used in our experiments, demonstrating that EV titers in VPS52 and VPS54 knockout (KO) cells were comparable to levels exhibited by ST-246-treated wild-type cells. Confocal microscopy was used to examine actin tail formation, one of the viral egress mechanisms for cell-to-cell dissemination, and revealed an absence of actin tails in VPS52KO- or VPS54KO-infected cells. Further evaluation of these cells by electron microscopy demonstrated a decrease in levels of wrapped viruses (WVs) compared to those seen with the wild-type control. Collectively, our data demonstrate the role of GARP complex genes in double-membrane wrapping of MVs necessary for EV formation, implicating the host endosomal trafficking pathway in orthopoxvirus infection.<b>IMPORTANCE</b> Human monkeypox is an emerging zoonotic infectious disease caused by <i>Monkeypox virus</i> (MPXV). Of the two MPXV clades, the Congo Basin strain is associated with severe disease, increased mortality, and increased human-to-human transmission relative to the West African strain. Monkeypox is endemic in regions of western and central Africa but was introduced into the United States in 2003 from the importation of infected animals. The threat of MPXV and other orthopoxviruses is increasing due to the absence of routine smallpox vaccination leading to a higher proportion of naive populations. In this study, we have identified and validated candidate genes that are required for MPXV infection, specifically, those associated with the Golgi-associated retrograde protein (GARP) complex. Identifying host targets required for infection that prevents extracellular virus formation such as the GARP complex or the retrograde pathway can provide a potential target for antiviral therapy.
Study of Localization Based on Fingerprinting Technique Using Uplink CSI in Cloud Radio Access Network (2019)

최근 5G 표준화가 본격화되고 실내위치관련 서비스에 대한 수요가 증가하면서, 실내 측위 기술에 대한 연구가 다양한 산업분야에서 연구되고 있으며, WLAN(Wireless Local Area Network)을 이용한 핑거프린팅 기법기반의 연구가 대표적이다. 본 논문은 UDN(Ultra Dense Network) 환경에서 C-RAN(Cloud Radio Access Network) 구조와 상향링크 CSI(Channel State Information)를 측위 기반정보로 사용하는 실내 측위 기술을 제안한다. 기존의 핑거프린팅 방식에 머신러닝 기술 중 하나인 KNN(K Nearest Neighbor) 기술을 결합하여 측위정확도를 개선하였으며, 성능 분석을 위해 구축된 테스트베드에서 수행된 기존 실내 측위 기술과 제안 기술의 성능 비교 실험을 통해, 제안하는 기술이 측위 정확도를 개선함을 확인하였다.
Mixed effects models for EEG evoked response detection (2008)

Human brain signals associated with perceptual processes have been shown to be useful for visual target image search. For the purpose of online training, we develop a novel mixed effects evoked response detector, which is capable of combining individual random effects and population fixed effects, for the analysis of neural signatures associated with targets. To avoid numerical problems in high dimensional matrix computations, we develop equivalent dimension reduced expressions for the mixed models. We construct the mixed effects evoked response model using principal component analysis to provide bases for the population model and linear discriminant analysis (LDA) to provide bases for the individual models. In addition, the LDA is adopted for Elecroencephalography channel dimensionality reduction. Data collected at different time and experimental conditions from two subjects performing image search tasks are utilized to assess the quality of the models. We also compare the proposed model with the support vector machine (SVM). The results demonstrate that the mixed models approach the SVM and provide reliable inference on cross session evaluation for the single-trial evoked response detection.
A Framework for Multiaccess Support for Unreliable Internet Traffic using Multipath DCCP (2019)

Mobile nodes are typically equipped with multiple radios and can connect to multiple radio access networks (e.g. WiFi, LTE and 5G). Consequently, it is important to design mechanisms that efficiently manage multiple network interfaces for aggregating the capacity, steering of traffic flows or switching flows among multiple interfaces. While such multi-access solutions have the potential to increase the overall traffic throughput and communication reliability, the variable latencies on different access links introduce packet delay variation which has negative effect on the application quality of service and user quality of experience. In this paper, we present a new IP-compatible multipath framework for heterogeneous access networks. The framework uses Multipath Datagram Congestion Control Protocol (MP-DCCP) - a set of extensions to regular DCCP - to enable a transport connection to operate across multiple access networks, simultaneously. We present the design of the new protocol framework and show simulation and experimental testbed results that (1) demonstrate the operation of the new framework, and (2) demonstrate the ability of our solution to manage significant packet delay variation caused by the asymmetry of network paths, by applying pluggable packet scheduling or reordering algorithms.
A modified phase error detector for frequency tracking in SISO/MIMO-OFDM systems (2006)

In this paper, a Modified Phase Error Detector (MPED) for frequency tracking in OFDM systems is proposed. The goal is to prevent the need for complete channel state (im- pulse response) information. The proposed algorithm explores both spatial and frequency diversity to improve the quality of the synchronization. When used as part of a DPLL (Digital Phase Locked Loop) in a frequency tracking loop, the proposed MPED delivers close to optimum performance without the need for channel state information.
13C NMR chemical shift assignments for some carbazole derivatives (1988)

Abstract 13 C NMR chemical shift assignments have been made for a series of 1‐substituted carbazoles, 8‐substituted 1,2,3,4‐tetra‐hydrocarbazoles, 1‐substituted benzo[ a ]carbazoles and 6‐substituted dibenzo‐[ c,g ]carbazoles. Single examples were examined of other classes of substituted carbazoles: 3‐butylcarbazole and its tetrahydro precursor 6‐butyl‐1,2,3,4‐tetra‐hydrocarbazole, 8‐butyl‐ and 8,10‐diethylbenzo[ a ]carbazoles and their 5,6‐dihydro precursors, dibenzo[ a,i ]carbazole and its 5,6,7,8‐tetrahydro precursor, benzo[ c ]carbazole and its 6‐chloro derivatives and 5,6‐dihydrobenzo[ c ]carbazole and 5,6,8,9‐tetrahydrodibenzo[ c,g ]carbazole and their N ‐methyl derivatives. In addition, the N ‐(1‐pyrrolidinomethyl) derivatives of carbazole, 1,2,3,4‐tetrahydrocarbazole, benzo[ c ]carbazole and dibenzo[ c,g ] carbazole were also studied.
Facile one-pot synthesis of polymer–phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy (2011)

This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.
ELF, Language Change, and Social Networks (2020)

This article extends ELF studies towards variationist and computational sociolinguistics. It uses social network theory to explore how ELF is embedded in the social structures in which it is used and explores the size and nature of social networks in ELF. The empirical part investigates if multilingual and often mobile ELF users have larger networks and more weak ties than others, and if they therefore could be more likely to act as innovators or early adopters of change than the other speaker groups. Our empirical material consists of real-time social media data from Twitter. The results show that, statistically speaking, social embedding of ELF creates conditions that favor change. ELF users have larger networks and more weak ties than the other groups examined here. With regard to methods, social embedding needs to be taken into account in future studies, and we illustrate that variationist and computational sociolinguistics offers a useful theoretical and methodological toolbox for this task.
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract (2020)

Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h<sup>2</sup> = 0.48), but little is known about specific genetic factors underlying this condition. Here we report findings from the largest to date multi-ethnic meta-analysis of genome-wide association studies (discovery cohort N = 14,151 and replication N = 5299) of the International Cataract Genetics Consortium. We confirmed the known genetic association of CRYAA (rs7278468, P = 2.8 × 10<sup>-16</sup>) with nuclear cataract and identified five new loci associated with this disease: SOX2-OT (rs9842371, P = 1.7 × 10<sup>-19</sup>), TMPRSS5 (rs4936279, P = 2.5 × 10<sup>-10</sup>), LINC01412 (rs16823886, P = 1.3 × 10<sup>-9</sup>), GLTSCR1 (rs1005911, P = 9.8 × 10<sup>-9</sup>), and COMMD1 (rs62149908, P = 1.2 × 10<sup>-8</sup>). The results suggest a strong link of age-related nuclear cataract with congenital cataract and eye development genes, and the importance of common genetic variants in maintaining crystalline lens integrity in the aging eye.
Fusion energy without radioactivity: laser ignition of solid hydrogen–boron (11) fuel (2010)

The advent of ultra-high power lasers allows laser power levels that are about 1000 times the power of all the power stations in the USA. This opens the way to new approaches for inertial confinement fusions (ICF) that in turn can drastically reduce the laser input energy needed to achieve practical ICF power. The specific approach discussed here involves inducing a fusion burn wave by laser-driven impact of a relatively large block of plasma on the outside of a solid density fusion target. This new method is specifically selected to enable the extremely attractive, but demanding, neutron-free proton–B-11 fusion that potentially can lead to the long sought goal of an ultra “clean” fusion power plant.
Supplemental Figure 8 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer (2023)

&lt;p&gt;Supplemental Figure 8&lt;/p&gt;
Segmentation problems (2004)

We study a novel genre of optimization problems, which we call segmentation problems , motivated in part by certain aspects of clustering and data mining. For any classical optimization problem, the corresponding segmentation problem seeks to partition a set of cost vectors into several segments , so that the overall cost is optimized. We focus on two natural and interesting (but MAXSNP-complete) problems in this class, the hypercube segmentation problem and the catalog segmentation problem, and present approximation algorithms for them. We also present a general greedy scheme, which can be specialized to approximate any segmentation problem.
Thermospray liquid chromatograph/mass spectrometer interface with direct electrical heating of the capillary (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermospray liquid chromatograph/mass spectrometer interface with direct electrical heating of the capillaryMarvin L. Vestal and Gordon J. FergussonCite this: Anal. Chem. 1985, 57, 12, 2373–2378Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ac00289a047https://doi.org/10.1021/ac00289a047research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
940 COMBINED EFFECTS OF ANGIOTENSIN II RECEPTOR ANTAGONIST AND CALCIUM CHANNEL BLOCKER IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES- (2012)

Objective: We comparatively studied the combined effects of 2 types of calcium channel blocker (CCB) (Azelnidipine tablet: AZL, Nifedipine CR tablet: NCR) in hypertensive patients with diabetes who have failed to achieve target blood pressure levels by usual dose of angiotensin II receptor antagonist (ARB). Methods: AZL 8-16 mg/day or NCR 10-40 mg/day was randomly allocated to 58 hypertensive patients with type 2 diabetes combined with valsartan 80 mg once after breakfast, and the dose was increased until they achieved their target blood pressure <130/80 mmHg (JSH2009). During the study, measurement of blood pressure/heart rate and hematology/urinalysis were performed for 6 months. Results: The doses of CCB were 17.1±9.4 mg/day in the AZL group and 13.2±3.9 mg/day in the NCR group (mean±SD). No significant difference was observed in the patients characteristics between the two groups. Twenty-two patients were with eGFR <60, and 46 patients with normal albuminuria. Although 65% or higher patients achieved target blood pressure level in month 6 in both groups, the blood pressure was significantly lower in the NCR group than the AZL group after month 2, and the rate of target attainment was significantly higher in the NCR group in month 4. The heart rate was decreased significantly in the NCR group. No changes were observed in the blood glucose, HbA1c, and urinary Alb/Cr in both groups, and eGFR was maintained favorably. No significant difference was observed in the changes in blood pressure and renal function in 22 patients with eGFR <60 at the study initiation in both groups. Conclusions: In type 2 diabetes patients with the stage 1-2 nephropathy, both high dose AZL and low dose NCR combined with ARB achieved target blood pressure levels, and could maintain the renal function favorably. It was confirmed that NCR has superior early antihypertensive effect and cost-effectiveness than AZL.
Microcavities for Cavity-QED in Single-Crystal Diamond (2009)

Optical microcavites fabricated by etching whispering gallery mode and photonic crystal structures in a high-index gallium phosphide layer and an underlying single-crystal diamond substrate are studied experimentally and theoretically.
Cation Ordering in Pb(Mg 1/3 Nb 2/3 )O 3 –Pb(Sc 1/2 Nb 1/2 )O 3 (PMN–PSN) Solid Solutions (2002)

Extended thermal annealing treatments were used to modify the B‐site cation order in the (1 − x )PMN– x PSN perovskite system (where PMN is lead magnesium niobate, Pb(Mg 1/3 Nb 2/3 )O 3 , and PSN is lead scandium niobate, Pb(Sc 1/2 Nb 1/2 )O 3 ). Extensive 1:1 ordering could be induced in compositions with x ≥ 0.1. The substitution of PSN into PMN produced a large increase in the thermal stability of the 1:1 ordered phase, with the maximum disordering temperature of ∼1360°C being observed for the x = 0.5 composition. By monitoring the change in the degree of order with temperature, the order–disorder boundary for the PMN–PSN system was established and the transition temperature for pure PMN was estimated to be ∼950°C. The changes in stability across the system were consistent with the “random‐site” description of the cation order. The change in enthalpy associated with the ordering was affected by the size difference of the two ordered cation sites and by the size and charge mismatch of the metal cations that occupy the random‐ site position.