gebhart/patrepeval huggingface dataset:
Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma (2005)

The extracellular matrix glycoprotein tenascin-C (TNC) has been accepted as a valuable histopathological subepithelial marker for evaluating the severity of asthmatic disease and the therapeutic response to drugs. We found an association between an adult asthma and an SNP encoding TNC fibronectin type III-D (Fn-III-D) domain in a case-control study between a Japanese population including 446 adult asthmatic patients and 658 normal healthy controls. The SNP (44513A/T in exon 17) strongly associates with adult bronchial asthma (chi2 test, P=0.00019, Odds ratio=1.76, 95% confidence interval=1.31-2.36). This coding SNP induces an amino acid substitution (Leu1677Ile) within the Fn-III-D domain of the alternative splicing region. Computer-assisted protein structure modeling suggests that the substituted amino acid locates at the outer edge of the beta-sheet in Fn-III-D domain and causes instability of this beta-sheet. As the TNC fibronectin-III domain has molecular elasticity, the structural change may affect the integrity and stiffness of asthmatic airways. In addition, TNC expression in lung fibroblasts increases with Th2 immune cytokine stimulation. Thus, Leu1677Ile may be valuable marker for evaluating the risk for developing asthma and plays a role in its pathogenesis.
A FULL-BODY GESTURE DATABASE FOR HUMAN GESTURE ANALYSIS (2007)

This paper presents a full-body gesture database which contains 2D video data and 3D motion data of 14 normal gestures, 10 abnormal gestures and 30 command gestures for 20 subjects. We call this database the Korea University Gesture (KUG) database. Using 3D motion cameras and 3 sets of stereo cameras, we captured 3D motion data and 3 pairs of stereo-video data in 3 different directions for normal and abnormal gestures. In case of command gestures, 2 pairs of stereo-video data were obtained by 2 sets of stereo cameras with different focal lengths in order to capture views of whole body and upper body, simultaneously. The 2D silhouette data was synthesized by separating a subject and background in 2D stereo-video data. In this paper, we describe the gesture capture system, the organization of database, the potential usages of the database and the contact point for the KUG database. We expect that this database would be very useful for the study of 2D/3D human gesture and its application.
Steady-State Contrast Response Functions Provide a Sensitive and Objective Index of Amblyopic Deficits (2015)

We suggest that SSVEPs offer a sensitive and objective measure of the ocular imbalance in amblyopia and could be used to assess the efficacy of amblyopia therapies currently under development.
Prospective Evaluation of 68Ga-RM2 PET/MRI in Patients with Biochemical Recurrence of Prostate Cancer and Negative Findings on Conventional Imaging (2017)

<sup>68</sup>Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH<sub>2</sub> (<sup>68</sup>Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptor (GRPr). GRPr proteins are highly overexpressed in several human tumors, including prostate cancer (PCa). We present data from the use of <sup>68</sup>Ga-RM2 in patients with biochemical recurrence (BCR) of PCa and negative findings on conventional imaging. <b>Methods:</b> We enrolled 32 men with BCR of PCa, who were 59-83 y old (mean ± SD, 68.7 ± 6.4 y). Imaging started at 40-69 min (mean, 50.5 ± 6.8 min) after injection of 133.2-151.7 MBq (mean, 140.6 ± 7.4 MBq) of <sup>68</sup>Ga-RM2 using a time-of-flight-enabled simultaneous PET/MRI scanner. T1-weighted, T2-weighted, and diffusion-weighted images were acquired. <b>Results:</b> All patients had a rising level of prostate-specific antigen (PSA) (range, 0.3-119.0 ng/mL; mean, 10.1 ± 21.3 ng/mL) and negative findings on conventional imaging (CT or MRI, and a <sup>99m</sup>Tc-methylene diphosphonate bone scan) before enrollment. The observed <sup>68</sup>Ga-RM2 PET detection rate was 71.8%. <sup>68</sup>Ga-RM2 PET identified recurrent PCa in 23 of the 32 participants, whereas the simultaneous MRI scan identified findings compatible with recurrent PCa in 11 of the 32 patients. PSA velocity was 0.32 ± 0.59 ng/mL/y (range, 0.04-1.9 ng/mL/y) in patients with negative PET findings and 2.51 ± 2.16 ng/mL/y (range, 0.13-8.68 ng/mL/y) in patients with positive PET findings (<i>P</i> = 0.006). <b>Conclusion:</b><sup>68</sup>Ga-RM2 PET can be used for assessment of GRPr expression in patients with BCR of PCa. High uptake in multiple areas compatible with cancer lesions suggests that <sup>68</sup>Ga-RM2 is a promising PET radiopharmaceutical for localization of disease in patients with BCR of PCa and negative findings on conventional imaging.
Statistical Process Control for Real-World Applications (2011)

"Statistical Process Control for Real-World Applications." Journal of Quality Technology, 43(4), pp. 383–384
Identification of Novel and Improved Antimitotic Agents Derived from Noscapine (2005)

Analogues of the natural product noscapine were synthesized and their potential as antitumor agents evaluated. The discovery of a novel regioselective O-demethylation facilitated the synthesis of the potent aniline 6, which arrests mammalian cells in the G2/M phase of the cell cycle at 0.1 microM and also affects tubulin polymerization. Aniline 6 is orally bioavailable and is 250-fold more potent than noscapine in reducing cell proliferation in rapidly dividing cells.
Selective production of furfural from the dehydration of xylose using Zn doped CuO catalyst (2019)

Furfural is a versatile biomass-derived platform compound used for the synthesis of several strategic chemicals. The sonochemically synthesized Zn doped CuO nanoparticles (NPs) were used for the production of furfural. The catalytic activity of the Zn doped CuO NPs was examined, as a model, during the dehydration reaction of xylose to furfural. In addition to that, we have also compared the catalytic activity of the Zn doped CuO NP with ZnO NPs, ZnO bulk, CuO NPs, CuO bulk, etc. This nanoscale catalyst (Zn doped CuO NP) has a large surface area, which enhances its catalytic activity and enables it to completely convert the xylose to furfural at 150 °C within 12 h without any trace of by-products, as confirmed by HPLC, <sup>13</sup>C NMR and <sup>1</sup>H NMR. HPLC analysis demonstrated that the yield of furfural is up to 86 mol %, compared to the 45 mol % obtained with ZnO NPs, ZnO bulk, CuO NPs, CuO bulk, etc. as catalysts.
Substituted Tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and Tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as Hypoglycemic Agents (1998)

A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. The in vivo hypoglycemic efficacy and potency of these compounds were evaluated in a model of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus), the ob/ob mouse. 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
Computing and visualizing the impact of change with Java PathFinder extensions (2012)

Change impact analysis techniques estimate the potential effects of changes made to software. Directed Incremental Symbolic Execution (DiSE) is a Java PathFinder extension that computes the impact of changes on program execution behaviors. The results of DiSE are a set of impacted path conditions that can be efficiently processed by a subsequent client analysis. Path conditions, however, may not be intuitive for software developers without the context of the source code. In this paper we present a framework for visualizing the results of DiSE. The visualization includes annotated source code and control ow graphs indicating program statements that are changed and statements that may be impacted by the changes. A simulation mode enables users to also observe the impact of changes on symbolic execution of the program, by showing the changes to the path conditions as the user steps through the sequences of statements executed.
Laser spectrophotometer for measuring differential cross sections of biological particles (1976)

A tunable laser spectrophotometer is described that can accurately measure the differential scattering cross sections of small particle suspensions in the visible spectral range. The instrument was calibrated using a suspension of latex spheres of known size and index of refraction. By increasing the intensity of the illuminating laser, it should be possible to study differential scattering processes of individual particles on a microsecond time scale.
Vibration insensitive interferometer using sinusoidal phase-modulation and feedback control (2006)

It is easy to extract a signal proportional to a phase fluctuation from a sinusoidally phase-modulated interference signal. This fluctuation is caused by mechanical vibration or air turbulence. In a sinusoidal phase-modulating interferometer using a laser diode (LD) the phase fluctuation is reduced by changing the injection current of the LD with a feedback control system. This control is very useful to a Fizeau type interferometer for surface profile measurement of a large size object. IC wafers of 100 mm diameter are measured with an interferometer insensitive to mechanical vibration and air turbulence. The phase fluctuation with nearly constant amplitude which corresponds to 30nm in surface height is reduced by about 10%. However the reduction in the phase fluctuation is not performed well for an instantaneous and large phase fluctuation. In order to be insensitive to all kinds of phase fluctuations the feedback signal is always observed, so that the interference signal is captured when the amplitude of the feedback signal is less than a specified level during the capturing time of 0.53 s. Thus surface profiles of the IC wafers can be measured with a high repeatability of a few nm even when any kind of vibration exists.
ChemInform Abstract: An Improved Large‐Scale Preparation of Benzimidazole‐2‐sulfonic Acids and 2‐Chlorobenzimidazoles. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Noninvasive Neuromonitoring of Hypothermic Circulatory Arrest in Aortic Surgery (2019)

The hemispheric asymmetry of frontal electroencephalogram is inherently resistant to generalized dampening effects and is predictive of primary neurological outcome. The brain symmetry index provides an easy-to-use, noninvasive neuromonitoring method for surgery of the thoracic aorta and postoperative intensive care.
Vacuum Surface Science Meets Heterogeneous Catalysis: Dehydrogenation of a Liquid Organic Hydrogen Carrier in the Liquid State (2015)

Ultrahigh vacuum (UHV) surface science techniques are used to study the heterogeneous catalytic dehydrogenation of a liquid organic hydrogen carrier in its liquid state close to the conditions of real catalysis. For this purpose, perhydrocarbazole (PH), otherwise volatile under UHV, is covalently linked as functional group to an imidazolium cation, forming a non-volatile ionic liquid (IL). The catalysed dehydrogenation of the PH unit as a function of temperature is investigated for a Pt foil covered by a macroscopically thick PH-IL film and for Pd particles suspended in the PH-IL film, and for PH-IL on Au as inert support. X-ray photoelectron spectroscopy and thermal desorption spectroscopy allows us to follow in situ the catalysed transition of perhydrocarbazole to carbazole at technical reaction temperatures. The data demonstrate the crucial role of the Pt and Pd catalysts in order to shift the dehydrogenation temperature below the critical temperature of thermal decomposition.
Evaluation of Endothelial and Vascular-Derived Progenitor Cell Populations in the Proximal and Distal UCL of the Elbow: A Comparative Study (2018)

These findings investigate one of the possible contributors to UCL healing after injury, which may provide insight into operative and nonoperative management of UCL injuries in the future. This study also indicates that reasons other than differences in progenitor cell density alone may explain the clinical healing differences seen between proximal and distal UCL tears. A better understanding of the microvascular environment and associated blood supply is warranted to understand the healing capability of the UCL.
RegulonDB (version 3.0): transcriptional regulation and operon organization in Escherichia coli K-12 (2000)

RegulonDB is a database on transcription regulation and operon organization in Escherichia coli. The current version describes regulatory signals of transcription initiation, promoters, regulatory binding sites of specific regulators, ribosome binding sites and terminators, as well as information on genes clustered in operons. These specific annotations have been gathered from a constant search in the literature, as well as based on computational sequence predictions. The genomic coordinates of all these objects in the E.coli K-12 chromosome are clearly indicated. Every known object has a link to at least one MEDLINE reference. We have also added direct links to recent expression data of E.coli K-12. The version presented here has important modifications both in the structure of the database, as well as in the amount and type of information encoded in the database. RegulonDB can be accessed on the web at URL: http://www.cifn.unam. mx/Computational_Biology/regulondb/
Extending test signal generation using sigma-delta encoding beyond the voltage/amplitude domain (2011)

This thesis extends signal generation techniques using sigma-delta encoding principles for synthesizing test signals of all types. In fact, sigma-delta encoding is used to generate repeatable and programmable noise-like signals; phase domain signals such as accurate phase offsets, sinusoidal and Gaussian jitter; and frequency domain signals used for accurate frequency synthesis. For the synthesis of noise-like signals, a Gaussian noise with the desired frequency characteristic is encoded in the voltage/amplitude domain in software using sigma-delta modulation. The resulting sequence of bits is then captured and applied cyclically to an analog filter to reconstruct the noise-like signal with the desired frequency spectrum (e.g. spectrum with a notch for noise-power ratio test). Moreover, a novel bit-to-bit mapping algorithm that converts digital signals to either phase or frequency, is proposed. A digital-to-time conversion (DTC) algorithm is used to convert a digital signal to the phase domain; likewise, a digital-to-frequency conversion (DFC) algorithm is used to convert a digital signal to the frequency domain. The DTC or DFC conversion algorithm is implemented in software together with the sigma-delta encoding process in order to digitally encode a phase or frequency domain signal. The resulting bit sequence with the desired phase or frequency signal is then captured and applied cyclically to an analog time/frequency-mode reconstruction filter. The time/frequency-mode filtering is realized by a PLL structure with the desired phase/frequency domain transfer function. All signal generation schemes (amplitude, noise, phase and frequency) consist of a digital bit-stream with the desired signal encoded and a reconstruction filtering device in the appropriate domain. Using the proposed techniques and circuits, robust, programmable, repeatable, and portable test signals in the amplitude, phase, and frequency domains can be synthesized at low-cost. Although the techniques are demonstrated in a production test environment using a commercial mixed-signal tester, the methodology can be implemented in any testing environment: production test, characterization test, design-for-test (DFT), or built-in self-test (BIST).
Distributed estimation with ad hoc wireless sensor networks (2006)

We consider distributed estimation of a deterministic parameter vector using an ad hoc wireless sensor network. The estimators derived are obtained as solutions of constrained convex optimization problems. Using the method of multipliers in conjunction with a block coordinate descent approach we demonstrate how the resultant algorithms can be decomposed into a set of simpler tasks suitable for distributed implementation. We show that these algorithms have guaranteed convergence to properly defined optimum estimators, and further exemplify their applicability to solving estimation problems where the signal model is completely or partially known at individual sensors. Through numerical experiments we illustrate that our algorithms outperform existing alternatives.
Metabolomic Profiling of Amino Acids and β-Cell Function Relative to Insulin Sensitivity in Youth (2012)

In youth, increased plasma AA concentrations are not associated with a heightened metabolic risk profile for T2DM; rather, they are positively associated with β-cell function relative to insulin sensitivity. These contrasting observations between adults and youth may be a reflection of developmental differences along the lifespan dependent on the combined impact of the aging process together with the impact of progressive obesity.
Single-image RGB Photometric Stereo With Spatially-varying Albedo (2016)

We present a single-shot system to recover surface geometry of objects with spatially-varying albedos, from images captured under a calibrated RGB photometric stereo setup---with three light directions multiplexed across different color channels in the observed RGB image. Since the problem is ill-posed point-wise, we assume that the albedo map can be modeled as piece-wise constant with a restricted number of distinct albedo values. We show that under ideal conditions, the shape of a non-degenerate local constant albedo surface patch can theoretically be recovered exactly. Moreover, we present a practical and efficient algorithm that uses this model to robustly recover shape from real images. Our method first reasons about shape locally in a dense set of patches in the observed image, producing shape distributions for every patch. These local distributions are then combined to produce a single consistent surface normal map. We demonstrate the efficacy of the approach through experiments on both synthetic renderings as well as real captured images.
Profiling Management for Personalised Multimedia Delivery On-Demand within the AXMEDIS Framework (2006)

Media content distribution on-demand becomes more complex when performed on a mass scale involving various channels with distinct and dynamic network characteristics, and, deploying a variety of terminal devices offering a wide range of capabilities. It is practically impossible to create and prepackage various static versions of the same content to match all the varying demand parameters of clients for various contexts. In this paper we present a profiling management approach for dynamically personalised media content delivery on-demand integrated with the AXMEDIS Framework. The client profiles comprise the representation of user, device, network and context of content delivery based on MPEG-21:DIA. Although the most challenging proving ground for this personalised content delivery has been the mobile testbed, i.e. the distribution to mobile handsets, the framework described here can be deployed for distribution, by the AXMEDIS PnP module, through other channels, e.g. satellite, Internet to a range of client terminals, e.g. desktops, kiosks, IPtv and other terminals whose baseline terminal capabilities can be made available by the manufacturers as is normal
A Switch to High-Flux Helixone<sup>®</sup> Membranes Reverses Suppressed Interferon-γ Production in Patients on Low-Flux Dialysis (2003)

Compared to low-flux polysulfone HD with ultrafiltered dialysate, high-flux HD with the synthetic Helixone membrane did not result in a significant change in plasma levels of proinflammatory (IL-6, CRP, IL-18) and anti-inflammatory (IL-1Ra, IL-18BP) cytokines. However, high-flux HD restores whole blood IFN-gamma production without significant changes in free IL-18. Therefore, the immune modulation in high-flux HD is likely due to removal of inhibitors of IFN-gamma production other than IL-18BP.
ChemInform Abstract: Synthesis of (.+‐.)‐7,8‐Epoxy‐4‐basmen‐6‐one by a Transannular Cyclization Strategy. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Promising Novel Technique for Tumor Localization in Laparoscopic Colorectal Surgery Using Indocyanine Green-Coated Endoscopic Clips (2020)

Lee, Dong Woon M.D.; Sohn, Dae Kyung M.D., Ph.D.; Han, Kyung Su M.D., Ph.D.; Hong, Chang Won M.D., Ph.D.; Park, Hyoung Chul M.D., Ph.D.; Oh, Jae Hwan M.D., Ph.D.Author Information
Rare-earth doped GaN electroluminescent devices for robust flat panel displays (2002)

The authors discuss the improvements required to make GaN:RE AC-ELDs overtake ZnS-based AC ELDs and possibly other flat panel devices (FPD) devices. Similar to the potential of other AC-ELD technologies, advances in GaN:RE AC-ELDs could be strongly considered for applications such as flat TVs.
Novel Electrolyte for Lithium Ion Batteries: Lithum Tetrafluorooxalatophosphate (LiPF4C2O4) (2009)

A novel salt for lithium ion battery electrolytes, lithium tetrafluorooxalatophosphate (LiPF4(C2O4)), has been prepared and investigated. The conductivity, electrochemical stability, and cycling performance of 1.0 M LiPF4(C2O4) in 1:1:1 ethylene carbonate:dimethyl carbonate:diethyl carbonate are comparable to the industry standard LiPF6 electrolyte. However, the LiPF4(C2O4) electrolyte has much better thermal stability. LiPF4(C2O4) electrolytes are a promising alternative for lithium ion batteries.
Plasma Growth Hormone is a Strong Predictor of Risk at 1 Year in Acute Heart Failure (2015)

GH offers incremental prognostic information over the ADHERE score clinical predictors and NT-proBNP for risk stratification of acute HF patients.
Object Recognition from Short Videos for Robotic Perception (2015)

Deep neural networks have become the primary learning technique for object recognition. Videos, unlike still images, are temporally coherent which makes the application of deep networks non-trivial. Here, we investigate how motion can aid object recognition in short videos. Our approach is based on Long Short-Term Memory (LSTM) deep networks. Unlike previous applications of LSTMs, we implement each gate as a convolution. We show that convolutional-based LSTM models are capable of learning motion dependencies and are able to improve the recognition accuracy when more frames in a sequence are available. We evaluate our approach on the Washington RGBD Object dataset and on the Washington RGBD Scenes dataset. Our approach outperforms deep nets applied to still images and sets a new state-of-the-art in this domain.