gebhart/patrepeval huggingface dataset:
Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation (2006)

The myristoylated alanine-rich C kinase substrate (MARCKS) is a primary protein kinase C (PKC) substrate in brain thought to transduce PKC signaling into alterations in the filamentous (F) actin cytoskeleton. Within the adult hippocampus, MARCKS is highly expressed in the dentate gyrus (DG)-CA3 mossy fiber pathway, but is expressed at low levels in the CA3-CA1 Schaffer collateral-CA1 pathway. We have previously demonstrated that 50% reductions in MARCKS expression in heterozygous Marcks mutant mice produce robust deficits in spatial reversal learning, but not contextual fear conditioning, suggesting that only specific aspects of hippocampal function are impaired by reduction in MARCKS expression. To further elucidate the role of MARCKS in hippocampal synaptic plasticity, in the present study we examined basal synaptic transmission, paired-pulse facilitation, post-tetanic potentiation, and long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 and Schaffer collateral-CA1 pathways of heterozygous Marcks mutant and wild-type mice. We found that LTP is significantly impaired in the mossy fiber-CA3 pathway, but not in the Schaffer collateral-CA1 pathway, in heterozygous Marcks mutant mice, whereas basal synaptic transmission, paired-pulse facilitation, and post-tetanic potentiation are unaffected in both pathways. These findings indicate that a 50% reduction in MARCKS expression impairs processes required for long-term, but not short-term, synaptic plasticity in the mossy fiber-CA3 pathway. The implications of these findings for the role of the mossy fiber-CA3 pathway in hippocampus-dependent learning processes are discussed.
Control-Oriented Modeling and Analysis for Automotive Fuel Cell Systems (2004)

Fuel Cells are electrochemical devices that convert the chemical energy of a gaseous fuel directly into electricity. They are widely regarded as a potential future stationary and mobile power source. The response of a fuel cell system depends on the air and hydrogen feed, flow and pressure regulation, and heat and water management. In this paper, we develop a dynamic model suitable for the control study of fuel cell systems. The transient phenomena captured in the model include the flow and inertia dynamics of the compressor, the manifold filling dynamics (both anode and cathode), reactant partial pressures, and membrane humidity. It is important to note, however, that the fuel cell stack temperature is treated as a parameter rather than a state variable of this model because of its long time constant. Limitations and several possible applications of this model are presented.
Highly Efficient Synthesis of O‐(2,4‐Dinitrophenyl)hydroxylamine. Application to the Synthesis of Substituted N‐Benzoyliminopyridinium Ylides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (2022)

Glofitamab therapy was effective for DLBCL. More than half the patients had an adverse event of grade 3 or 4. (Funded by F. Hoffmann-La Roche; ClinicalTrials.gov number, NCT03075696.).
In Vitro Systems for the Study of T Cell Development: Fetal Thymus Organ Culture and OP9‐DL1 Cell Coculture (2006)

Most T cell development occurs within the thymus and includes a series of selection processes that are, in large part, still poorly understood. Studies of T cell development have been greatly advanced by the description of multiple phenotypic subsets of T cells and their maturational relationships. This unit describes a system for observing and modulating T cell development in vitro via the culture of entire mouse fetal thymic lobes. Methods are included for the isolation of fetal thymi and culture to allow for normal T cell development on either transwell plates or Gelfoam sponges. A method for depleting hematopoietic cells from thymic lobes using 2'-deoxyguanosine and subsequent reconstitution with precursor cells is also described. This protocol is valuable for the study of tolerance and T cell selection. A support protocol describing methods of altering and monitoring T cell development are outlined. In addition, methods for culturing fetal thymic lobes under high oxygen submersion conditions and for the preparation of reaggregate thymus organ cultures are provided. Finally, a simple and practical method that allows for the thymus-independent generation of T cells from defined sources of stem/progenitor cells by OP9-DL1 coculture is described.
Fabrication of Electrospray Thrusters with a High-Density Emitter Array Utilizing Minimal-Fab System (2018)

Using a fabrication technology of field emitter arrays (FEAs), we have fabricated a high-density emitter array with 5-10 μm pitch as ion sources to improve the thrust density of electrospray thrusters. The emitter array is made on a Si wafer and consists of double Nb electrodes with sub-μm apertures, where ionic liquid as the propellant is expected to be extracted by applying voltage to the electrodes. This array can realize the emitter density of up to four million/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , which is four orders of magnitude higher than that of conventional electrospray thrusters.
Welcome BACK to the DARK Side: DARK Classics in Chemical Neuroscience II (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTWelcome BACK to the DARK Side: DARK Classics in Chemical Neuroscience IICraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445Cite this: ACS Chem. Neurosci. 2020, 11, 23, 3849Publication Date (Web):December 2, 2020Publication History Published online2 December 2020Published inissue 2 December 2020https://pubs.acs.org/doi/10.1021/acschemneuro.0c00716https://doi.org/10.1021/acschemneuro.0c00716editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1622Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (454 KB) Get e-AlertscloseSUBJECTS:Chemical neuroscience,Neuroscience,Nicotine,Pharmaceuticals,Teaching and learning methods Get e-Alerts
Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients (2021)

'retrospectively registered'.
The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS) (2022)

Diabetes Prevention Program: NCT00004992 ; Diabetes Prevention Program Outcomes Study: NCT00038727.
Microwave-Assisted Synthesis of Silver Vanadium Phosphorus Oxide, Ag2VO2PO4: Crystallite Size Control and Impact on Electrochemistry (2016)

Silver vanadium phosphorus oxide, Ag2VO2PO4, is a promising cathode material for Li batteries due in part to its large capacity and high current capability. Herein, a new synthesis of Ag2VO2PO4 based on microwave heating is presented, where the reaction time is reduced by approximately 100× relative to other reported methods, and the crystallite size is controlled via synthesis temperature, showing a linear correlation of crystallite size with temperature. Notably, under galvanostatic reduction, the Ag2VO2PO4 sample with the smallest crystallite size delivers the highest capacity and shows the highest loaded voltage. Further, pulse discharge tests show a significant resistance decrease during the initial discharge coincident with the formation of Ag metal. Thus, the magnitude of the resistance decrease observed during pulse tests depends on the Ag2VO2PO4 crystallite size, with the largest resistance decrease observed for the smallest crystallite size. Additional electrochemical measurements indicate a quasi-reversible redox reaction involving Li+ insertion/deinsertion, with capacity fade due to structural changes associated with the discharge/charge process. In summary, this work demonstrates a faster synthetic approach for bimetallic polyanionic materials which also provides the opportunity for tuning of electrochemical properties through control of material physical properties such as crystallite size.
Innovationshürden beseitigen: wie die Einführung medizintechnischer Innovationen in die Gesundheitsversorgung beschleunigt werden kann (2009)

Die Medizintechnik ist ein wichtiger Baustein der Gesundheitsversorgung – allerdings hat diese innovative Branche viele Hürden zu überwinden: ein Kernproblem sind die langen Zulassungs- und Erstattungswege medizintechnischer Innovationen, die schnelles Wachstum und damit das Schaffen von Arbeitsplätzen erschweren. Insbesondere kleinere Unternehmen scheitern oftmals, weil sie die hohe Vorfinanzierung aufgrund langer Zulassungs- und Vergütungswege nicht leisten können. acatech – Deutsche Akademie der Technikwissenschaften drängt deshalb darauf, die Empfehlungen der Akademie umzusetzen. So könnten unnötige Hürden für medizintechnische Innovationen beseitigt werden.
Supplementary Table S1-S5 from Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis (2023)

&lt;p&gt;ST1: Composition of the modified AIN-93G diet used in the animal experiment; ST2: Sequences of primers in qRT-PCR; ST3: Concentrations of lipid mediators in the plasma of control mice (not treated with AOM/DSS) and colon cancer mice (treated with AOM/DSS); ST4: Concentrations of lipid mediators in the colon of control mice (not treated with AOM/DSS) and colon cancer mice (treated with AOM/DSS); ST5: Concentrations of lipid mediators in the colon of AOM/DSS-treated Cyp2c+/+ and Cyp2c+/- mice.&lt;/p&gt;
As-S and As-Se based photonic band gap fiber for IR laser transmission (2003)

IR transmissive As-S glass and As-Se glass triangular photonic band gap fiber structures are theoretically modeled. The potential for propagation of air-guided modes in the defect regions of these fibers is demonstrated by the large out of plane two-dimensional photonic band gaps found in these structures. Fiber design for IR light propagation is discussed.
Semiconducting single-walled carbon nanotube/graphene van der Waals junctions for highly sensitive all-carbon hybrid humidity sensors (2020)

All-carbon van der Waals junction humidity sensors exhibit high sensitivity and millisecond response/recovery times due to efficient charge transfer.
Stimulation Contractility Gradient of a Neuromuscular Choristoma Within the Sciatic Nerve: 2-Dimensional Operative Video (2018)

Neuromuscular choristoma (NMC) is a rare congenital nerve lesion that is classified by the presence of heterotopic muscle fibers intercalated within nerve fascicles.1 The presence of NMC typically causes progressive neuropathy and bony/soft tissue undergrowth, often leading to a shortened atrophic limb.2,3 The typical appearance of NMC on magnetic resonance imaging is an enlarged fusiform nerve that exhibits minimal gadolinium enhancement.4 While there is increasing documentation of pathognomonic clinical and radiographic features for various diffuse fusiform peripheral nerve lesions, nerve biopsy is still occasionally required for some patients given the rarity of these diseases and progressive neuropathic features.The intraoperative appearance of NMC and its unique electrical stimulation properties are quite interesting. Intrafascicular replacement of nerve by skeletal muscle gives the nerve a red beefy color and causes the fascicles to contract with electrical stimulation.5 In this video, we demonstrate the intraoperative appearance and contractile properties of NMC in a 60-yr-old woman with progressive sciatic neuropathy. Histologic and immunohistochemical studies identified a gradient of intralesional mature skeletal muscle within the NMC, with substantially fewer desmin-positive skeletal muscle fibers in the distal aspect. A gradient of contractility with intraoperative stimulation seemed to correlate with this pathology. These findings suggest that the lesional extent of NMC may not be clinically or grossly evident, reflecting a varying distribution of skeletal muscle within the affected nerve.The Mayo Clinic Institutional Review Board Office for Human Research Protection does not require approval for single participant case studies. The subject involved in this study was not identifiable and the general surgical consent form included permission for intraoperative photos and video.
Phase-Change and Redox-Based Resistive Switching Memories (2015)

This paper addresses the two main resistive switching (RS) memory technologies: phase-change memory (PCM) and redox-based resistive random access memory (ReRAM). It will review the basic concepts, the initial promises, and current state of the art, with focus on possible scaling pathways for low-power operation and dense, true 3-D memory. Recent physical insights and new potential concepts will be discussed.
Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli (2021)

Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its modular nature, the simplified production process in comparison to traditional chemical conjugation methods, and its amenability to scaled-up operations. As a result, a considerable reduction in production time and cost is expected, making PGCT-made vaccines a suitable vaccine technology for low-middle income countries, where vaccine coverage remains predominantly low and inconsistent. This work aims to develop an integrated whole-process automated platform for the screening of PGCT-made glycoconjugate vaccine candidates. The successful translation of a bench scale process for glycoconjugate production to a microscale automated setting was achieved. This was integrated with a numerical computational software that allowed hands-free operation and a platform adaptable to biological variation over the course of a production process. Platform robustness was proven with both technical and biological replicates and subsequently the platform was used to screen for the most favourable conditions for production of a pneumococcal serotype 4 vaccine candidate. This work establishes an effective automated platform that enabled the identification of the most suitable E. coli strain and genetic constructs to be used in ongoing early phase research and be further brought into preclinical trials.
Lamivudine treatment for fulminant hepatic failure due to acute exacerbation of chronic hepatitis B infection (2001)

Lamivudine may be useful in treating patients with fulminant hepatic failure due to exacerbation of chronic hepatitis B. Hepatitis B e antigen seroconversion was less durable in this subgroup of patients and long-term therapy may be required.
Carbon Dioxide Capture and Separation Techniques for Gasification-based Power Generation Point Sources (2007)

The capture/separation step for carbon dioxide (CO2) from large-point sources is a critical one with respect to the technical feasibility and cost of the overall carbon sequestration scenario. For large-point sources, such as those found in power generation, the carbon dioxide capture techniques being investigated by the in-house research area of the National Energy Technology Laboratory possess the potential for improved efficiency and reduced costs as compared to more conventional technologies. The investigated techniques can have wide applications, but the research has focused on capture/separation of carbon dioxide from flue gas (post-combustion from fossil fuel-fired combustors) and from fuel gas (precombustion, such as integrated gasification combined cycle or IGCC). With respect to fuel gas applications, novel concepts are being developed in wet scrubbing with physical absorption; chemical absorption with solid sorbents; and separation by membranes. In one concept, a wet scrubbing technique is being investigated that uses a physical solvent process to remove CO2 from fuel gas of an IGCC system at elevated temperature and pressure. The need to define an ideal solvent has led to the study of the solubility and mass transfer properties of various solvents. Pertaining to another separation technology, fabrication techniques and mechanistic studies for membranes separating CO2 from the fuel gas produced by coal gasification are also being performed. Membranes that consist of CO2-philic ionic liquids encapsulated into a polymeric substrate have been investigated for permeability and selectivity. Finally, dry, regenerable processes based on sorbents are additional techniques for CO2 capture from fuel gas. An overview of these novel techniques is presented along with a research progress status of technologies related to membranes and physical solvents.
The inverse problem in magnetic force microscopy—inferring sample magnetization from MFM images (2013)

Nanomagnetic structures have the potential to surpass silicon's scaling limitations both as elements in hybrid CMOS logic and as novel computational elements. Magnetic force microscopy (MFM) offers a convenient characterization technique for use in the design of such nanomagnetic structures. MFM measures the magnetic field and not the sample's magnetization. As such the question of the uniqueness of the relationship between an external magnetic field and a magnetization distribution is a relevant one. To study this problem we present a simple algorithm which searches for magnetization distributions consistent with an external magnetic field and solutions to the micromagnetic equations' qualitative features. The algorithm is not computationally intensive and is found to be effective for our test cases. On the basis of our results we propose a systematic approach for interpreting MFM measurements.
NASA/ORNL/AFRL Project Work on EBM LSHR: Additive Manufacturing of High-Temperature Gamma-Prime Strengthened Ni-Based Superalloys (2016)

Powder-bed fabrication of aerospace alloys may revolutionize production by eliminating the need for extensive machining and expensive tooling. Heated-bed electron-beam melting (EBM) offers advantages over non-heated laser additive manufacturing (AM) methods, including lower residual stress, reduced risk of contamination, slower cooling rates, and faster build times. NASA Glenn Research Center has joint project work with Oak Ridge National Lab and the Air Force Research Laboratory to explore the feasibility of fabricating advanced Ni-based gamma-prime superalloys with EBM AM.
Plant-derived single domain COVID-19 antibodies (2023)

Data show a decrease in the risk of hospitalization and death from COVID-19. To date, global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are urgently needed to prevent and cure infection among naïve and even vaccinated people. Neutralizing monoclonal antibodies are very promising for prophylaxis and therapy of SARS-CoV-2 infections. However, traditional large-scale methods of producing such antibodies are slow, extremely expensive and possess a high risk of contamination with viruses, prions, oncogenic DNA and other pollutants. The present study is aimed at developing an approach of producing monoclonal antibodies (mAbs) against SARS-CoV-2 spike (S) protein in plant systems which offers unique advantages, such as the lack of human and animal pathogens or bacterial toxins, relatively low-cost manufacturing, and ease of production scale-up. We selected a single N-terminal domain functional camelid-derived heavy (H)-chain antibody fragments (VHH, AKA nanobodies) targeted to receptor binding domain of SARS-CoV-2 spike protein and developed methods of their rapid production using transgenic plants and plant cell suspensions. Isolated and purified plant-derived VHH antibodies were compared with mAbs produced in traditional mammalian and bacterial expression systems. It was found that plant generated VHH using the proposed methods of transformation and purification possess the ability to bind to SARS-CoV-2 spike protein comparable to that of monoclonal antibodies derived from bacterial and mammalian cell cultures. The results of the present studies confirm the visibility of producing monoclonal single-chain antibodies with a high ability to bind the targeted COVID-19 spike protein in plant systems within a relatively shorter time span and at a lower cost when compared with traditional methods. Moreover, similar plant biotechnology approaches can be used for producing monoclonal neutralizing antibodies against other types of viruses.
Das Nucleus Double Array Cochlear Implant: Ein neues Konzept bei obliterierter Cochlea (1999)

In cases involving an obliterated cochlea, the number of intracochlear electrodes can be increased with the double array implant. As a result, the patients achieve significantly better auditory results.
<title>Mode-Controlled Galnasp-Inp Long Wavelength Lasers</title> (1981)

GaInAsP/InP lasers with wavelengths of 1.0-1.7µ1-7 have been intensively developed because the optical fibers have their minimum transmission losses in this wavelength region8-9. The transverse mode control obtained in index-guiding structures is very important to im-prove lasing properties, such as modulation linearity, and longitudinal mode behavior as justified experimentally and theoretically. 10-15 Recently single transverse and longitudi-nal mode operation of GaInAsP/InP lasers with index-guiding effect have been realized in various structures.18-28 Newly, 1.6pm wavelength GaInAsP/InP buried heterostructure (BH) lasers have been operated at room temperature in CW condition.21, 22 We also presented, thus far, other types of novel mode-controlled GaInAsP/InP lasers.19,28 In this paper, three types of mode controlled GaInAsP/InP lasers are discussed: (1) buried heterostructure lasers with 1.6&mu;m wavelength, (2) mesa substrate buried hetero-structure (MSB) lasers and (3) terraced substrate (TS) lasers with 1.3-&mu;m wavelength. Specially, the lasing characteristics of 1.6-&mu;m wavelength BH lasers are given. In these de-vices threshold currents as low as 28 mA and differential quantum efficiencys of 43% under room temperature CW condition could be obtained.