gebhart/patrepeval huggingface dataset:
Staphylococcus aureus vWF-binding protein triggers a strong interaction between clumping factor A and host vWF (2021)

The Staphylococcus aureus cell wall-anchored adhesin ClfA binds to the very large blood circulating protein, von Willebrand factor (vWF) via vWF-binding protein (vWbp), a secreted protein that does not bind the cell wall covalently. Here we perform force spectroscopy studies on living bacteria to unravel the molecular mechanism of this interaction. We discover that the presence of all three binding partners leads to very high binding forces (2000 pN), largely outperforming other known ternary complexes involving adhesins. Strikingly, our experiments indicate that a direct interaction involving features of the dock, lock and latch mechanism must occur between ClfA and vWF to sustain the extreme tensile strength of the ternary complex. Our results support a previously undescribed mechanism whereby vWbp activates a direct, ultra-strong interaction between ClfA and vWF. This intriguing interaction represents a potential target for therapeutic interventions, including synthetic peptides inhibiting the ultra-strong interactions between ClfA and its ligands.
Amorphous Co-Ti alloy as a single layer barrier for Co local interconnect structure (2016)

This paper reports a new local interconnect structure using Co M0/contact and a Co-Ti amorphous single layer barrier. Good adhesion and low film resistivity were obtained for as-deposited and annealed samples. The metal-oxide-semiconductor samples of Co/Co-Ti/SiO2/p-Si showed a high breakdown voltage and no negative shift of flat band voltage after annealing up to 700 °C for 10 min. The amorphous structure of the Co-Ti layer was maintained throughout annealing and prevented Co diffusion into dielectric. The obtained results indicated that Co-Ti could be a potential candidate to replace conventional local interconnect structure of Ti/TiN.
Informatics-assisted Protein Profiling in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (2006)

One of the causes of amyotrophic lateral sclerosis (ALS) is due to mutations in Cu,Zn-superoxide dismutase (SOD1). The mutant protein exhibits a toxic gain of function that adversely affects the function of neurons in the spinal cord, brain stem, and motor cortex. A proteomic analysis of protein expression in a widely used mouse model of ALS was undertaken to identify differences in protein expression in the spinal cords of mice expressing a mutant protein with the G93A mutation found in human ALS. Protein profiling was done on soluble and particulate fractions of spinal cord extracts using high throughput two-dimensional liquid chromatography coupled to tandem mass spectrometry. An integrated proteomics-informatics platform was used to identify relevant differences in protein expression based upon the abundance of peptides identified by database searching of mass spectrometry data. Changes in the expression of proteins associated with mitochondria were particularly prevalent in spinal cord proteins from both mutant G93A-SOD1 and wild-type SOD1 transgenic mice. G93A-SOD1 mouse spinal cord also exhibited differences in proteins associated with metabolism, protein kinase regulation, antioxidant activity, and lysosomes. Using gene ontology analysis, we found an overlap of changes in mRNA expression in presymptomatic mice (from microarray analysis) in three different gene categories. These included selected protein kinase signaling systems, ATP-driven ion transport, and neurotransmission. Therefore, alterations in selected cellular processes are detectable before symptomatic onset in ALS mouse models. However, in late stage disease, mRNA expression analysis did not reveal significant changes in mitochondrial gene expression but did reveal concordant changes in lipid metabolism, lysosomes, and the regulation of neurotransmission. Thus, concordance of proteomic and mRNA expression data within multiple categories validates the use of gene ontology analysis to compare different types of "omic" data.
High-power picosecond soliton fiber lasers using chirped fiber Bragg gratings (1995)

Applications in telecommunication and instrumentation currently drive a vigorous research effort towards the construction of tunable high power sources of picosecond pulses.1 Particularly, passively-mode-locked fiber lasers appear very attractive for providing these functions; however, a problem has been that passively-mode-locked fiber lasers typically tend to produce pulses near the bandwidth limit of the gain medium, giving rise to pulses significantly shorter than 1 ps.2
Two-channel emission controlled by a conjugation valve for the color switching of thermally activated delayed fluorescence emission (2019)

Herein, we demonstrate the first example of molecular design concept combining the two channel emission process and conjugation managing valve structure for emission color control and high light-emitting efficiency of the TADF emitters.
On the performance of IEEE 802.11 QoS mechanisms under spectrum competition (2006)

WLANs based on IEEE 802.11 are becoming more and more popular both in commercial and residential settings. However, the very success of 802.11 may become a threat to the technology itself. Since there are only a limited number of non-overlapping channels available in the IEEE 802.11 WLAN standards, this can lead to interference among WLANs in dense areas. In this paper, we investigate the effects of interference on WLANs when they operate in DCF, PCF, and EDCA modes in order to support QoS sensitive traffic, such as Voice over IP (VoIP). The results show that DCF, PCF, and EDCA will suffer considerably under these conditions and will not be able to provide good support for real-time applications. From our results, we can infer that the polling mechanism with centralized control on which the 802.11e standard is based will not be a suitable access control mechanism under spectrum competition. Thus, there is a need to change the current technical direction of QoS support in WLANs for future dense deployments.
Integrated multi-operand electro-optic logic gates for optical computing (2019)

Integrated optical computing has the potential to enhance the computation abilities in terms of computing speed and power consumption during the post-Moore's law era. As one of the widely investigated approaches, electro-optic logic uses electro-optic switches as the building blocks to achieve complex functions. In this paper, we propose and experimentally demonstrate a multioperand electro-optic logic gate that contains multiple active regions in a single gate to further increase the versatility of gates. Thus, one gate can be controlled by several electrical inputs simultaneously. The ability of multioperand logic gates is thoroughly explored. The detailed comparison shows that the proposed gate can largely improve the circuit performance in terms of the area, latency, power, and insertion loss. We believe the multioperand logic gate has the potential to contribute to a more compact and power-efficient integrated optical computing system.
On the role of self-interstitials in impurity diffusion in silicon (1980)

The question of whether the monovacancy or the self-interstitial is the point defect responsible for impurity diffusion is reviewed in the light of buried marker diffusion experiments and irradiation-enhanced diffusion data. It is concluded that coupled vacancy-impurity diffusion is the preferred interpretation, but no definite conclusions can be drawn. However, the role of the self-interstitial in diffusion is proposed through a model which assumes that during oxidation, exchanges can take place between vacancies, self-interstitials, impurity interstitials, and substitutional impurities. By assuming a partial interstitialcy diffusion model it is shown that ?10–20% of the impurity flux during nonoxidizing diffusion conditions is due to impurity interstitials displaced by self-interstitials in equilibrium in the silicon. Calculations of impurity interstitial formation energies are consistent with the degree of oxidation enhanced diffusion measured for boron, phosphorus, and arsenic.
Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer (2021)

Erlotinib was covalently linked to 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) and structurally related chlorins and bacteriochlorins at different positions of the tetrapyrrole ring. The functional consequence of each modification was determined by quantifying the uptake and subcellular deposition of the erlotinib conjugates, cellular response to therapeutic light treatment in tissue cultures, and in eliminating of corresponding tumors grown as a xenograft in SCID mice. The experimental human cancer models the established cell lines UMUC3 (bladder), FaDu (hypopharynx), and primary cultures of head and neck tumor cells. The effectiveness of the compounds was compared to that of HPPH. Furthermore, specific functional contribution of the carboxylic acid side group at position 17<sup>2</sup> and the chiral methyl group at 3(1') to the overall activity of the chimeric compounds was assessed. Among the conjugates investigated, the PS <b>10</b> was identified as the most effective candidate for achieving tumor cell-specific accumulation and yielding improved long-term tumor control.
High-speed and high-definition technology by multibeam scanning in laser printing (2001)

Multi-beam scanning is the effective method for high speed and high definition in Laser Printing, and there are three systems for this method as follows: (1) Laser Diode (LD) Array system, (2) System for dividing a single light source, (3) System for combining beams of multiple LDs by optical devices. Each of these systems has both advantage and disadvantage, and which one to use among these three depends on application requirements. The third system above allows for the use of conventional LDs and therefore it is low cost and offers a large degree of freedom in selecting light sources. We have already developed a Two LD Prism-based Light Source Unit that uses a prism to combine the beams emitted by two LDs. This system achieves stable optical characteristics with any conventional scanning optical elements. We have further enhanced this system. We have determined an optimum design that includes scanning lens and have developed the Two LD Beam-crossing Light Source Unit which performs multi-beam scanning using two LDs without a prism. In this paper, we report on recent multi-beam-scanning technologies and introduce our newly developed the Two LD Beam-crossing Light Source Unit.
Abstract 1550: Bruteforcing immune oncology discovery with computational immuno-engineering (2019)

Abstract Recent Nobel awards in immune checkpoint inhibitor biology, phage display discovery and protein evolution highlight our current golden age of immune oncology research. While it took 15 years to bring anti-CTLA4 and anti-PD1 therapeutics from conception to global patient populations, new advances in synthetic and data driven immune engineering are enabling new therapeutics to be discovered and engineered in weeks rather than years. Here we review ten years of progress in computational optimization of antibody discovery libraries through the lens of high-throughput data collection technologies, with specific case studies of modern repertoire design principles applied to a panel of immune checkpoint targets. We emphasize the case study of PD1, where a computationally optimized library generated over 6500 unique anti-PD1 antibodies in two weeks, including picomolar binders, mouse/cyno/human triple cross-reactive epitopes, antagonists, agonists, and saturated epitope coverage of the target. Citation Format: Sarah Ives, David Maurer, Christina Pettus, Raymond Newland, Valerie Chiou, Shahrad Daraeikia, Chelsea Jones, Kieran Hervold, Giles Day, Chris Smith, Ian D. Waddell, Sawsan Youssef, Jacob Glanville. Bruteforcing immune oncology discovery with computational immuno-engineering [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1550.
Ionitronic manipulation of current-induced domain wall motion in synthetic antiferromagnets (2021)

Abstract The current induced motion of domain walls forms the basis of several advanced spintronic technologies. The most efficient domain wall motion is found in synthetic antiferromagnetic (SAF) structures that are composed of an upper and a lower ferromagnetic layer coupled antiferromagnetically via a thin ruthenium layer. The antiferromagnetic coupling gives rise to a giant exchange torque with which current moves domain walls at maximum velocities when the magnetic moments of the two layers are matched. Here we show that the velocity of domain walls in SAF nanowires can be reversibly tuned by several hundred m/s in a non-volatile manner by ionic liquid gating. Ionic liquid gating results in reversible changes in oxidation of the upper magnetic layer in the SAF over a wide gate-voltage window. This changes the delicate balance in magnetic properties of the SAF and, thereby, results in large changes in the exchange coupling torque and the current-induced domain wall velocity. We also illustrate the potential of ionitronic spintronic logic devices with a ‘knot’ racetrack device.
Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases (2006)

PAX6/Pax6 gene encodes a transcription factor that is crucially required for eye development. Pax6 heterozygous mutant mouse (Pax6(Sey/+)) shows various ocular defects, especially in the anterior segment. It has been well known that the induction of the lens and development of the cornea and retina are dependent on PAX6/Pax6 in a cell-autonomous fashion, although the influence of PAX6/Pax6 on the other tissues derived from the ocular mesenchyme is largely unknown. Using transgenic mouse lines in which neural crest cells are genetically marked by LacZ or EGFP, we revealed the extensive contribution of neural crest derived cells (NCDCs) to the ocular tissues. Furthermore, various eye defects in Pax6(Sey/+) mouse were accompanied by abnormal distribution of NCDCs from early developmental stages to the adult. In Pax6(Sey/+) mouse mice, neural crest cells abnormally migrated into the developing eye in a cell nonautonomous manner at early embryonic stages. These results indicate that normal distribution and integration of NCDCs in ocular tissues depend on a proper dosage of Pax6, and that Pax6(Sey/+) eye anomalies are caused by cell autonomous and nonautonomous defects due to Pax6 haploinsufficiency.
Quantification of the binding kinetics of targeted ultrasound contrast agent for molecular imaging of cancer angiogenesis (2015)

Cancer growth requires angiogenesis; imaging of angiogenesis holds thus great potential for improved cancer detection and treatment. In this context, ultrasound molecular imaging permits the visualization of cancer angiogenesis by use of novel targeted contrast agents (tUCA). These consist of ligand-bearing microbubbles designed to specifically bind molecular angiogenic expressions, thus providing selective enhancement especially in the late phase after injection. Discrimination between bound and free microbubbles is crucial to assess the degree of binding and thus to quantify angiogenesis. Currently, binding is mainly assessed by the differential targeted enhancement, i.e., the difference in signal intensity in the late phase before and after the application of a high-pressure destructive pulse. However, this method is not quantitative, and it requires long acquisitions and a high-pressure pulse, which may damage the endothelial tissue. To overcome these limitations, here we propose a new method for quantification of the microbubble binding kinetics by fitting a dedicated compartmental model to the tUCA first-pass. We investigated the feasibility of the method in three prostate tumor-bearing rats. The novel information provided by the proposed method may be combined with the late enhancement analysis to gain deeper insight into tumor angionesis, and thus potentially improve cancer diagnosis and management.
Integrated GMR angle sensor for electrical commutated motors including features for safety critical applications (2010)

An integrated GMR (Giant Magneto Resistance) angle sensor will be presented which is designed to fulfill requirements for electrical commutated motor-drives. These motors use sine-commutation for the coils and need the angle of the motor-shaft in accuracy ranges below 1∘ with update-rates of 50- 100 μs. This integrated GMR Angle sensor solves this problem using integrated GMR Angle-Sensors on top of the silicon signal processing chip. The differential GMR-bridge signals are converted to the digital domain by sigma-delta ADCs and these raw-signals are error-compensated. An additional autocalibration feature is implemented to improve the accuracy during operation. The very fast angle-measurement is performed using parallel analog signal processing, 24 MHz finite state machine with dedicated peripherals and an 8 Mbit/s SPI interface. An additional feature to reduce the time delay is the implemented angle-value prediction. Built-in selftests, switchable voltages for signal-path tests and multiple safety voltage comparators are implemented for safety-critical applications.
Safe increase of the TCP's Initial Window Using Initial Spreading (Internet Draft) (2014)

INTERNET-DRAFT
Activation Parameters and Stereochemistry of an Antibody‐Catalyzed Claisen Rearrangement (1992)

The catalysis of the same reaction through different mechanisms was attributed to the diversity of the immune response. The chorismate–prephenate conversion 1 → 3 can be catalyzed by antibodies raised against an analogue of the transition state 2. These antibodies give rise to a variety of activation parameters for the catalysis. An extremely low activation entropy was found for the antibody 11F1-2E11, which supports the notion that conformational restriction may play an important role in antibody catalysis.
Coding for Multilevel Heterogeneous Memories (2010)

We consider the problem of information storage in multilevel heterogeneous memories, where different cells can support different data level-sets. Such heterogeneity arises due to variability in the physical cell characteristics in emerging technologies such as Phase Change Memory (PCM) technology, which is our specific motivation. We show that the heterogeneous memory problem can be formulated in terms of the information-theoretic `Channel Coding with Side-Information at Transmitter' (CSIT) paradigm. We present a binary decomposition of the problem, and show that this decomposition allows for simple binary code constructions. We discuss one such code-construction based on binary Luby Transform (LT) code matrices. We present simulation results using cell variability data collected from a PCM test array, and show that the proposed approach can yield a significant advantage in storage capacity.
Photoelectron spectra of tris(dialkylaminophosphines). A controversy (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoelectron spectra of tris(dialkylaminophosphines). A controversyJ. H. Hargis and S. D. WorleyCite this: Inorg. Chem. 1977, 16, 7, 1686–1689Publication Date (Print):July 1, 1977Publication History Published online1 May 2002Published inissue 1 July 1977https://doi.org/10.1021/ic50173a023RIGHTS & PERMISSIONSArticle Views32Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (538 KB) Get e-Alertsclose Get e-Alerts
Novel Heterocycle-Based Two-Photon\nAbsorbing Dyes (2016)

The synthesis and nonlinear optical characterization of two novel heteroaromatic-based chromophores is described. The new dyes present an\nA−π−D−π−A general framework, where A is a π-deficient heteroaromatic ring (pyridine, quinoline, benzothiazole) and D a π-excessive pyrrolyl\nmoiety. Both systems exhibit large two-photon absorption (TPA) values in the femtoseconds regime (TPA cross section as high as 150 × 10&lt;sup&gt;-50&lt;/sup&gt;\ncm&lt;sup&gt;4&lt;/sup&gt; s photon&lt;sup&gt;-1&lt;/sup&gt; molecule&lt;sup&gt;-1&lt;/sup&gt; with 150 fs laser pulses). Their TPA-based optical limiting activity is also shown.
Highly luminescent lanthanide complexes based on salicylamide-type ligands: Versatile molecules for luminescence applications in water (2000)

LCSL
Dynamics of the metal-insulator transition of donor-dopedSrTiO3 (2016)

The electrical properties of donor-doped $\mathrm{SrTi}{\mathrm{O}}_{3}$ $(n$-STO) are profoundly affected by an oxidation-induced metal-insulator transition (MIT). Here we employ dynamical numerical simulations to examine the high-temperature MIT of $n$-STO over a large range of time and length scales. The simulations are based on the Nernst-Planck equations, the continuity equations, and the Poisson equation, in combination with surface lattice disorder equilibria serving as time-dependent boundary conditions. The simulations reveal that $n$-STO, upon oxidation, develops a kinetic space charge region (SCR) in the near-surface region. The surface concentrations of the variously mobile defects (electrons, Sr vacancies, and O vacancies) are found to vary over time and to differ considerably from the values of the new equilibrium. The formation of the SCR in which electrons are strongly depleted occurs within nanoseconds, i.e., it yields a fast MIT in the near-surface region during the oxidation process. As a result of charge (over-)compensation by Sr vacancies incorporated at the surface of $n$-STO, this SCR is much more pronounced than conventionally expected. In addition, we find an anomalous increase of O vacancy concentration at the surface upon oxidation caused by the SCR. Our simulations show that the SCR fades in the long term as a result of the slow in-diffusion of Sr vacancies. We discuss implications for the electrical conductivity of $n$-STO crystals used as substrates for epitaxial oxide thin films, of $n$-STO thin films and interfaces, and of polycrystalline $n$-STO with various functionalities.
Message from the Chairman (2012)

On behalf of the Technical and Local Committee of the IEEE International Conference on Imaging Systems and Techniques (IST 2012), I would like to welcome you to the vibrant city of Manchester, United Kingdom, a city with a rich history in engineering and technology.