gebhart/patrepeval huggingface dataset:
Nanoporous delivery system to treat osteomyelitis and regenerate bone: Gentamicin release kinetics and bactericidal effect (2005)

Conventional treatment of osteomyelitis involves the repeated surgical removal of dead bone tissue coupled with repeated irrigation of the wound and prolonged systemic administration of antibiotics. Therapy of bone infections could easily last the rest of the patient's life because of the poor accessibility of the infection site by common systemically administered antibiotics. The objective of the present study is to develop a novel bone bioactive resorbable nanocomposite that can serve as a delivery system for antibiotics. We synthesized three different samples of porous bioactive resorbable silica-calcium phosphate nanocomposite (C3S1, C1S1, and C1S3) that has the ability to provide a sustained release of effective dose of gentamicin for 28 days. Porosity measurements showed that the average pore diameter of C3S1, C1S1, and C1S3 samples is 44.8, 54.4, and 70.9 nm, respectively. Moreover, the silica-rich composite (C1S3) is characterized by a significantly higher surface area (155.8 m(2)/g) than the silica-poor samples (C3S1) (42.9 m(2)/g). For all samples, the release profile study showed initial burst release followed by a sustained release of gentamicin. The released gentamicin has a strong inhibitory effect on Staphylococcus aureus bacteria. In addition FTIR analysis showed the formation of a biological apatite layer on the material surface after 24 h of immersion in simulated body fluid. Results of the study suggest that the silica-calcium phosphate nanocomposite can serve as a delivery vehicle for gentamicin to treat osteomyelitis and regenerate bone.
Joint subchannel matching and power allocation for the MIMO broadcast relay channel (2010)

We propose a joint matching and relay power allocation scheme based on an interference-free architecture for the multiuser multiple-input multiple-output (MIMO) broadcast relay channel. Instead of using brute-force search, we propose a matching scheme that assigns the better subchannels at the first hop to the destinations with lower power costs. It is shown that the proposed matching scheme is optimal for certain power allocation schemes. Simulation results show that proposed matching scheme combined with water-filling power allocation is nearly optimal for the joint optimization problem of matching and power allocation.
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (1987)

The synthesis, physicochemical properties, and antitumor activity of a series of N-[2-(dialkylamino)alkyl]-acridine-4-carboxamides are reported. The compounds bind to DNA by intercalation, but exist under physiological conditions as monocations due to the weakly basic acridine chromophore (pKa = 3.5-4.5). The acridine-4-carboxamides show very broad structure-activity relationships (SAR) for antileukemic activity, with substituents at nearly all acridine positions proving acceptable. The compounds also show remarkable activity against the Lewis lung solid tumor in vivo, with several analogues capable of effecting 100% cures of the advanced disease. The broad SAR and high solid-tumor activity of the 9-acridine-4-carboxamides imply they should be considered as a completely new class of antitumor agent.
Purification of Treponema pallidum, Nichols Strain, by Percoll Density Gradient Centrifugation (1984)

The purification of motile and virulent Treponema pallidum, Nichols strain, from rabbit testicular tissue is reported. Suspensions of T. pallidum were overlayed onto 20-ml cushions of 43% Percoll and in-situ density gradients were formed by centrifugation at 34,800 g for 30 min. Gradient fractionation indicated that T. pallidum banded at a density of 1.051 g/cc3 and that soluble proteineous testicular components remained in the upper portion of the gradient. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) confirmed the removal of host testicular and serum components. Purified suspensions of T. pallidum were greater than 95% actively motile and fully virulent, and greater than 50% motility could be maintained in vitro for up to five days. As determined by electron microscopy, Percoll-purified T. pallidum was structurally unaltered and contained much less tissue debris than did crude extracts or T. pallidum prepared by differential centrifugation. The Percoll purification method has been applied successfully to physiology, recombinant DNA, and antigenic structure studies, and to the preparation of antigen for the fluorescent treponemal antibody-absorbed (FTA-Abs) test for syphilis.
Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. (1988)

We have obtained 10 mAb from two independent fusions that are anti-idiotypic to the combining site of an anti-I-Jk antibody. These mAb block Ts cell function isn a genetically restricted manner in vitro and in vivo and recognize a determinant on macrophage membranes. In addition, they do not affect the I-Ek-restricted activation of a Th cell line specific for pigeon heart cytochrome c. We conclude that these mAb may recognize a molecule other than conventional I-Ek on cells interacting with Ts cells that is involved in mediating Ts activity. The molecule recognized may be a modified I-Ek molecule or a molecule not encoded by the genes encoding I-Ek.
Measurement System For Attenuation, Numerical Aperture (NA), Dispersion, And Optical Time-Domain Reflectometry (OTDR) In Infrared (IR) Optical Fibers (1986)

A computer-based measurement system capable of measuring the attenuation, NA, dispersion, and OTDR in IR optical fibers is described. A review of measurement theory is presented. The hardware and software elements of the measurement system are discussed. The system operates from 2.8-14.0 &mu;m using Pb-salt laser diodes. 500-MHz bandwidth HgCdTe detectors and a waveform digitizer are used in the dispersion and OTDR measurements. The optical layout and computer interface is described. Measurement technique and data from chalcogenide optical fibers is presented.
Combined scalability support for the scalable extension of H.264/AVC (2005)

The scalability extension of H.264/AVC (H. Schwarz, et al., 2004) uses a layered approach for providing spatial, temporal, and SNR scalability. Due to this concept, only a restricted set of spatio-temporal-SNR points can be extracted and decoded from a global scalable bit-stream, and this set of points is defined by the chosen encoder configuration. In this paper, we present a new approach for providing flexible combined spatial, temporal, and SNR scalability. The increased flexibility is achieved by introducing NAL units that represent a refinement signal for a picture in a coarse-to-fine-description and can be truncated at any arbitrary point. The simulation results show that this approach is capable of providing flexible combined scalability while the coding efficiency is only slightly worse than that of the layered approach.
Crystallization study of “melt quenched” amorphous GeTe by transmission electron microscopy for phase change memory applications (2011)

In situ transmission electron microscopy (TEM) observations were performed for a better understanding of the “melt quenched” GeTe crystallization mechanism. The evolution of the crystallite morphology observed during annealing shows a growth-dominated crystallization behavior. Scanning transmission electron microscopy—electron dispersive x-ray spectroscopy and high resolution electron microscopy experiments were also performed on cycled GeTe devices, showing that void formation is responsible for the cell failure after 107 cycles.
Editor's Note: Diphenyl Difluoroketone: A Curcumin Derivative with Potent In Vivo Anticancer Activity (2022)

The editors are publishing this note to alert readers to concerns with this article (1). Specifically, in Fig. In addition, in Fig.
Dynamic Traffic Management for Green Open Access Femtocell Networks (2012)

The exponential increase in high rate traffic driven by the new generation of wireless services is expected to overload cellular network capacity in the near future. Femtocell networks have recently been proposed as an efficient and cost-effective solution to enhance cellular network capacity and coverage. However, dense and unplanned deployment of new Base Stations (BSs) and their uncoordinated operation may increase the system power consumption and rise co-channel interference. Thus, efficient schemes are essential for managing femtocell activity and improving the system performance. Classical cell switch off and discontinuous transmission (DTX) algorithms aim at improving the network Energy Efficiency (EE) in lightly loaded scenarios. In this paper, we propose a novel multi-cell architecture for Open Access femtocell networks, which also enables energy saving at medium and high loads without compromising the end-user performance.
Cavitation Corrosions in Capillary Pulsating Heat Pipe (2018)

When vapor bubbles are subjected to suddenly reduced pressure or immediate subcooling, it may rapidly condense, rupture, and generate cavitation corrosions. This phenomenon often occurs behind the blade of a rapidly rotating propeller or on any surface vibrating in liquid with sufficient amplitude and acceleration. In this article, we reported cavitation and its corrosive collapse occurring in capillary tubes, called pulsating heat pipes. Visualization images of cut and opened tubes show that internal copper surface was seriously etched after a certain period of operation. Sub-millimeter etching pits are observed on the tube internal surface. Copper particles in size of a few hundred micrometers are also found in the reclaimed operating fluid. Starting from this finding, the temperature effect of performance is analyzed to understand the cavitation occurrence and collapse. Pulsating heat pipe requires a certain temperature difference between the evaporator and condenser sections, typically &gt; 10°C, to generate continuous two-phase oscillating movements. However, during the transient startup period, this temperature difference could reach as high as 50°C. Large saturation temperature difference, associated with highly turbulent two-phase flow, drives the saturated vapor bubbles from the hot evaporation region to the subcooled environment in less than 100ms. During the rapid condensation, the accelerated shrinking vapor bubbles create interface instability, followed by forming a strong impingement jet to etch the solid pipe wall. The collapse of cavitation is associated with the generation of acoustically tinkling signals that are often heard during most of the operating pulsating heat pipe.
Fibroblast tubulin (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFibroblast tubulinRichard Ostlund and Ira PastanCite this: Biochemistry 1975, 14, 18, 4064–4068Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://pubs.acs.org/doi/10.1021/bi00689a022https://doi.org/10.1021/bi00689a022research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A tensorial thermodynamic framework to account for the γ ' rafting in nickel-based single crystal superalloys (2016)

A new model is developed in order to account for the effect of microstructural degradation (i.e. precipitate-directional-coarsening) on the viscoplastic behavior of single crystal superalloys under high temperature exposure. Microstructural changes are modeled by a tensorial description of γ channel width evolution formulated in the natural anisotropy basis of the material. The tensorial description of microstructural evolution is combined with the Kelvin modes based viscoplasticity laws thanks to the coupling with the Orowan stress performed within a thermodynamics framework. Isotropic and directional coarsening of the γ ′ hardening phase are modeled as well as its dissolution with temperature changes. Results are presented for isothermal creep of CMSX-4 alloy at 1050 • C along < 001 > and < 111 > crystal directions but the formulation allows to account for anisothermal loadings, isotropization of the creep response at high temperature and misaligned loadings. This newly developed tensorial framework for rafting can also apply to single crystal superalloys having a positive misfit.
Capillary Zone Electrophoresis Separation of Recombinant Human Interleukin-3 and Related Proteins (1989)

Zone electrophoresis separations of human recombinant interleukin-3 (rh IL-3) and related proteins in untreated fused silica capillaries are presented. Results using pH 9 CHES buffer show that rh IL-3 is easily separated from a common carrier, human serum albumin, in a commercial preparation.
The NEBULA RPC-Optimized Architecture (2020)

Large-scale online services are commonly structured as a network of software tiers, which communicate over the datacenter network using RPCs. Ongoing trends towards software decomposition have led to the prevalence of tiers receiving and generating RPCs with runtimes of only a few microseconds. With such small software runtimes, even the smallest latency overheads in RPC handling have a significant relative performance impact. In particular, we find that growing network bandwidth introduces queuing effects within a server's memory hierarchy, considerably hurting the response latency of fine-grained RPCs. In this work we introduce NEBULA, an architecture optimized to accelerate the most challenging microsecond-scale RPCs, by leveraging two novel mechanisms to drastically improve server throughput under strict tail latency goals. First, NEBULA reduces detrimental queuing at the memory controllers via hardware support for efficient in-LLC network buffer management. Second, NEBULA's network interface steers incoming RPCs into the CPU cores' L1 caches, improving RPC startup latency. Our evaluation shows that NEBULA boosts the throughput of a state-of-the-art key-value store by 1.25- 2.19 x compared to existing proposals, while maintaining strict tail latency goals.
Adaptive Activity and Environment Recognition for Mobile Phones (2014)

In this paper, an adaptive activity and environment recognition algorithm running on a mobile phone is presented. The algorithm makes inferences based on sensor and radio receiver data provided by the phone. A wide set of features that can be extracted from these data sources were investigated, and a Bayesian maximum a posteriori classifier was used for classifying between several user activities and environments. The accuracy of the method was evaluated on a dataset collected in a real-life trial. In addition, comparison to other state-of-the-art classifiers, namely support vector machines and decision trees, was performed. To make the system adaptive for individual user characteristics, an adaptation algorithm for context model parameters was designed. Moreover, a confidence measure for the classification correctness was designed. The proposed adaptation algorithm and confidence measure were evaluated on a second dataset obtained from another real-life trial, where the users were requested to provide binary feedback on the classification correctness. The results show that the proposed adaptation algorithm is effective at improving the classification accuracy.
The Effect of Tetanus-Diphtheria-Acellular-Pertussis Immunization During Pregnancy on Infant Antibody Responses: Individual-Participant Data Meta-Analysis (2021)

CRD42017079171.
Plasmonic Planet–Satellite Analogues: Hierarchical Self-Assembly of Gold Nanostructures (2012)

In the past few years, a remarkable progress has been made in unveiling novel and unique optical properties of strongly coupled plasmonic nanostructures, known as plasmonic molecules. However, realization of such plasmonic molecules using nonlithographic approaches remains challenging largely due to the lack of facile and robust assembly methods. Previous attempts to achieve plasmonic nanoassemblies using molecular ligands were limited to dipolar assembly of nanostructures, which typically results in polydisperse linear and branched chains. Here, we demonstrate that core-satellite structures comprised of shape-controlled plasmonic nanostructures can be achieved through self-assembly using simple molecular cross-linkers. Prevention of self-conjugation and promotion of cross-conjugation among cores and satellites plays a key role in the formation of core-satellite heteroassemblies. The in-built electromagnetic hot-spots and Raman reporters of core-satellite structures make them excellent candidates for surface-enhanced Raman scattering probes.
Isolation and characterization of transducing phage coding for sigma subunit of Escherichia coli RNA polymerase. (1979)

A transducing phage has been isolated with codes for the sigma subunit of Escherichia coli RNA polymerase. Transducing phage were selected from E. coli shotgun collections of HindIII or Sac I fragments cloned into Charon 25, a new bacteriophage lambda vector that is capble of forming lyosogens at high temperature. Transduction of an E. coli strain carrying a temperature-sensitive mutation in the sigma gene was used for the selection. The positions of restriction sites for Sac I, HindIII, Xho I, Bgl II, and Kpn I in the cloned bacterial DNA segments were determined. Phage containing the HindIII fragment complement both primase (dnaG) and sigma (rpoD) whereas those containing the Sac I fragment complement only sigma. Results of analyses of the proteins made both in vivo after infection of UV-irradiated cells and in vitro in a coupled transcription/translation system suggest that a Sac I site separates the promoter for sigma from the sigma structural gene. The direction of transcription of sigma was determined to be clockwise with respect to the E. coli genetic map.
NATIVE PLANTS FOR OPTIMIZING CARBON SEQUESTRATION IN RECLAIMED LANDS (2001)

Carbon emissions and atmospheric concentrations are expected to continue to increase through the next century unless major changes are made in the way carbon is managed. Managing carbon has emerged as a pressing national energy and environmental need that will drive national policies and treaties through the coming
Prediction of the Inductance in a Synchronous Linear Permanent Magnet Generator (2011)

This paper presents calculations of the varying inductances profile for a synchronous linear surface mounted permanent magnet generator in an ABC reference system. Calculations are performed by utilizing the reluctance term, known from analytic calculations and finite element method simulations. With the inductance term identified, the voltage difference between the generator’s no load and load voltage can be calculated and an external circuit can be designed for optimal use of the generator. Two different operation intervals of the linear generator are considered and the results are discussed. The result indicates that time costly finite element simulations can be replaced with simple analytical calculations for a surface mounted permanent magnet linear generator.
The Monolanthanide‐Containing Silicotungstates [Ln(β2‐SiW11O39)2] 13‐ (Ln: La, Ce, Sm, Eu, Gd, Tb, Yb, Lu): A Synthetic and Structural Investigation. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A high data rate LiFi integrated system with inter-cell interference management (2018)

In this paper, we describe the first fully integrated Optical Wireless Communication (OWC) network solution with inter-cell interference management. This network uses novel LiFi integrated and real-time modems that implement advanced physical (PHY), Medium Access Control (MAC) and Logical Link Control (LLC) layers allowing adaptive rates up to 42 Mbit/s at PHY layer and a configurable number of supported users per lamp. On top of that, a network layer is designed and implemented to manage inter-cellular interference optimizing the spatial reuse of the resources. Hence, link quality of interfered unserved users is improved and the aggregated network throughput is drastically increased for typical indoor deployment compared to existing solutions without interference management. This whole system eases the deployment of LiFi lighting access points' networks in a dynamic auto-discovery manner (i.e., reconfiguration without operator's intervention).
Propulsion motor concepts for airplanes (2019)

Compact, lightweight, highly efficient motors are being sought for airplane electric propulsion. Superconducting motors rated 3 MW, 4500 RPM have been identified as possible candidate propulsion systems for commercial aircraft. Based on a preliminary parametric design analysis, this paper discusses three types of superconducting motors for such applications; • Synchronous motors employing superconducting field winding on the rotor • Induction motors employing superconducting squirrel cage winding • Homopolar AC synchronous motors employing superconducting field winding The performance characteristics and component challenges for each type of machine are discussed. Parameters included in the comparison are size, mass and efficiency. It appears that the superconducting wound rotor motors have characteristics of highest power density and efficiency but have significant challenges in supplying coolant and electric power to the rotating field winding. An induction motor employing superconducting squirrel cage windings only requires cooling of the rotor i.e. no current needs to be transferred to the rotor. The squirrel cage is expected to be carried on the rotor in a copper cylinder which is non-magnetic in nature. Thus, there is high reluctance between the stator winding and the squirrel cage. The larger reluctance considerably weakens the magnetic coupling between the two, which makes the machine bulkier and less efficient than the synchronous machine. It might be possible to build the induction motor with a superconducting stator, but that would require a large amount of superconductor. Lastly, the AC homopolar machine is expected to be less compact and power-dense than the synchronous machine but has the advantage of carrying all windings on the stator which are easy to cool, thus eliminating challenges of supplying power or coolant to the rotor.
Characterization of Thiol‐Ene Crosslinked PEG Hydrogels (2012)

The properties of synthetic hydrogels can be tuned to address the needs of many tissue-culture applications. This work characterizes the swelling and mechanical properties of thiol-ene crosslinked PEG hydrogels made with varying prepolymer formulations, demonstrating that hydrogels with a compressive modulus exceeding 600 kPa can be formed. The amount of peptide incorporated into the hydrogel is shown to be proportional to the amount of peptide in the prepolymer solution. Cell attachment and spreading on the surface of the peptide-functionalized hydrogels is demonstrated. Additionally, a method for bonding distinct layers of cured hydrogels is used to create a microfluidic channel.