gebhart/patrepeval huggingface dataset:
FINDING JOBS IN BIOPHARMA (2008)

RETURN TO ISSUEPREVBook ReviewNEXTFINDING JOBS IN BIOPHARMABook is a guide to MYRIAD PATHWAYS in the biotech industry for all playersKENNETH J. BARRCite this: Chem. Eng. News 2008, 86, 20, 48–49Publication Date (Print):May 19, 2008Publication History Published online14 November 2010Published inissue 19 May 2008https://pubs.acs.org/doi/10.1021/cen-v086n020.p048https://doi.org/10.1021/cen-v086n020.p048book-reviewACS PublicationsCopyright © 2008 AMERICAN CHEMICAL SOCIETYArticle Views11Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Biotechnology,Pharmaceuticals,Phase transitions Get e-Alerts
A 12- or 48-V Input, 0.9-V Output Active-Clamp Forward Converter Power Block for Servers and Datacenters (2019)

DC-to-DC power supplies are critical components for processors in high performance computing and datacenter servers. Conversion from an intermediate bus voltage (e.g., 12 or 48 V) to the core voltage (∼0.9 V) of processors must be efficient, compact, and cost effective. This paper proposes two versions of active-clamp forward converter (ACFC) power blocks to supply core voltage from either 12 or 48 V intermediate bus voltage. The ACFC power block can be individually tested prior to assembly and vertically soldered onto the motherboard to fit in a standard 1U server. A low loss, compact planar transformer is designed into the ACFC power block printed circuit board (PCB). A custom, standing slab inductor not only provides high inductance and high saturation current but also helps to mechanically support the power block. A one-piece copper winding connects the transformer to the inductor, thereby reducing the dc loss in the current path. Thorough analysis is performed to model the conversion loss of the proposed power block. Experimental results show a peak efficiency of 90.4% (12 V input) and 89.5% (48 V input) with 0.9-V output.
Fabrication and Surface Characterization of DNA Microarrays Using Amine- and Thiol-Terminated Oligonucleotide Probes (2002)

A versatile chemistry utilizing the homobifunctional cross-linker 1,4-phenylene diisothiocyanate (PDC) to attach both amine- and thiol-terminated oligonucleotides to aminosilane-coated slides was examined in a microarray format. Three common aminosilanes, 3-aminopropyltriethoxysilane (APS), N-(2-aminoethyl)-3-aminopropyltrimethoxysilane, and m,p-(aminoethyl-aminomethyl) phenethyltrimethoxysilane, were coated onto glass slides and silicon wafers and characterized using contact angle goniometry, ellipsometry, and X-ray photoelectron spectroscopy. Evaluation of the aminosilane-modified surfaces using contact angle measurements, UV−vis spectroscopy, and covalent attachment of a Cy5-conjugated N-hydroxysuccinimide ester reporter molecule suggested that derivatization of the surface with APS + PDC resulted in the best overall coverage. Microarrays printed using APS + PDC chemistry to immobilize both amine- and thiol-terminated oligonucleotides resulted in rapid attachment, uniform spot morphology, and minimal background fluorescence. Both amine- and thiol-terminated oligonucleotides showed comparable attachment, although greater attachment and hybridization efficiencies were observed with amine-functionalized molecules at saturating printing densities. The data highlight the influence of surface chemistry on both immobilization and hybridization and, by extrapolation, on microarray data analysis.
Impact of Via Stub Position on High Speed Serial Links (2018)

While designing any interface, the impact of channel components like vias, trace, materials, stack-up, connectors, cables, transmitter/receiver packages, and other parasitic effects need to be considered. This paper discusses the impact of via and more importantly the impact of via stub position and length on high speed serial links. Via stub resonance impacts high speed signals but in this paper it is shown that their position also has an impact. Depending on where the via stubs are located on a high speed channel, sometimes their effect could be insignificant (no eye degradation) and sometimes their impact could be significant (major eye degradation). High speed analysis is performed at 16Gbps and 20Gbps to demonstrate the margin loss due to various positions of via stubs.
ChemInform Abstract: A Rapid Screening Test to Determine the Antioxidant Potencies of Natural and Synthetic Antioxidants. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Robust Mean-field Game of Boltzmann-Vlasov-like Traffic Flow (2021)

Historically, traffic modelling approaches have taken either a particle-like (microscopic) approach, or a gas-like (meso- or macroscopic) approach. Until recently with the introduction of mean-field games to the controls community, there has not been a rigorous framework to facilitate passage between controls for the microscopic models and the macroscopic models. We begin this work with a particle-based model of autonomous vehicles subject to drag and unknown disturbances, noise, and a speed limit in addition to the control. We formulate a robust stochastic differential game on the particles. We pass formally to the infinite-particle limit to obtain a robust mean-field game PDE system. We solve the mean-field game PDE system numerically and discuss the results. In particular, we obtain an optimal control which increases the bulk velocity of the traffic flow while reducing congestion.
Vascular Structure and Function Is Correlated to Cognitive Performance and White Matter Hyperintensities in Older Hypertensive Patients With Subjective Memory Complaints (2009)

Our data suggest that vascular abnormalities, independently of blood pressure levels, may play a role in the setting of subjective memory complaints as well as of WMH in elderly hypertensive patients. Arterial thickness and stiffness as well as endothelial function should be assessed simultaneously and may represent additional targets for the prevention of subjective memory complaints and WMH.
Message from the chairs (2010)

AMPS is the first Workshop at an international level, sponsored by the IEEE Instrumentation and Measurement Society, in the field of measurement in power systems. AMPS 2010 is aimed at highlighting measurement issues and challenges in modern electric power networks and at encouraging broad discussion about methodologies and results among participants.
Contribution à l'étude et à la réalisation de lasers à fibre dopée aux ions de terres rares (1991)

L'objet de cette these est l'etude et la realisation de lasers a fibre dopee aux ions de terres rares. Dans ces structures guidantes, le confinement de la lumiere autorise des seuils d'oscillation laser tres bas, le fonctionnement en continu de systemes a trois niveaux, de nouvelles transitions laser et l'utilisation de diodes de pompage a semi-conducteur. L'abondance de phenomenes et de types de fonctionnements font des fibres dopees un sujet d'etude passionnant. Le travail presente comprend une premiere partie de spectroscopie des ions neodyme, erbium, holmium, praseodyme dans des fibres silice et verre fluore en vue d'application laser. Une deuxieme partie est consacree a l'etude du laser nd#3#+ a 1. 08 microns dans la silice. Le modele presente repose sur une forme d'equations de bloch tenant compte des pertes dependant de la frequence et de l'elargissement non-homogene de la transition a 1. 08 microns. Il permet de calculer et d'expliquer pour la premiere fois la dynamique de l'allumage d'un laser ainsi que d'autres proprietes liees a la competition de modes
Apoptosis, proliferation, and hormone receptors in endometrial carcinoma: Results depending on methods of analysis (2003)

Apoptosis and proliferation were studied in 29 endometrial adenocarcinomas of the endometrioid type and characterized by the immunohisto-chemical pattern of estrogen receptor (ER) alpha and progesterone receptor (PR) expression. Intratumoral heterogeneous distribution of both ER and PR as well as of the proliferation marker Ki-67 was studied and quantified. Both density and heterogeneity of the two steroid receptors and Ki-67 varied, depending on the histological malignancy grade (grades 1-3, or G1-3); interestingly, however, the apoptotic index (Ai) was in the same range for all grades. Receptor staining was evaluated by three different methods: i) counting the percentage of stained cells (staining index), according to stereological principles; ii) the mixed method, a combination of the staining index results and ranking staining intensity; and iii) a superficial and rapid visual scoring. The three methods gave equal results. Apoptotic cells and bodies were generally scattered in the endometrial carcinoma but more frequently observed adjacent to necrotic foci. Bcl-2, known as anti-apoptotic factor, showed no correlation to apoptotic index, Ki-67 expression, ER, or PR. Overexpression of p53 was seen in two tumors of grade 3. In a detailed study of intra-tumoral microfoci performed on consecutively taken tissue sections, a higher staining index of both ER and PR was found in the areas of maximal proliferation compared with the areas of minimal proliferation in tumors of grades 1-2, but not in G3 tumors. Other covariations were also found when non-specified areas were studied. The Ki-67 index was both higher and more heterogeneous in G2-3 tumors than in G1 tumors. Our results indicate that there is an increasing discrepancy between cell death and cell proliferation with progressing tumor grade, which may contribute to the differences in tumor aggressivity.
Component Stress−Strain Behavior and Small-Angle Neutron Scattering Investigation of Stereoblock Elastomeric Polypropylene (2003)

Elastomeric polypropylene (ePP) produced from unbridged 2-arylindene metallocene catalysts was studied by uniaxial tensile and small-angle neutron scattering (SANS) techniques. The ePP can be separated into the following: a low tacticity fraction soluble in ether (ES), an intermediate tacticity fraction soluble in heptane (HS), and a high tacticity fraction insoluble in heptane (HI). Tensile properties of ePP were compared to its solvent fractions, and the role of each solvent fraction residing within ePP was investigated by blending 5 wt % deuterated fraction with ePP. The tensile properties of each fraction vary considerably, exhibiting properties from a weak gum elastomer for ES, to a semicrystalline thermoplastic for HI. The intermediate tacticity HS fraction exhibits elastic properties similar to the parent elastomer (ePP). In the melt at 160 °C, SANS shows that all deuterated fractions are homogeneously mixed with ePP. Slow cooling from the melt to 25 °C causes the low tacticity fraction to preferentially segregate in amorphous domains due to different crystallization temperatures and kinetics although, despite its low crystallinity (≤2%), the low tacticity fraction can cocrystallize with the matrix. The dES-ePP shows little or no relaxation when held under strain and recovers readily upon the release of stress. The high tacticity component (dHI-ePP) retains its plastic properties in the blend.
Derivation and application of hard deadlines for real-time control systems (1992)

A method for calculating the hard deadlines in linear time-invariant control systems by considering system stability and the allowed state-space is presented. To derive necessary conditions for asymptotic system stability, the state difference equation is modified based on an assumed maximum delay and the probability distribution of delays whose magnitudes are less than, or equal to, the assumed maximum delay. The allowed state-space-which is derived from given input and state constraints-is used to calculate the hard deadline as a function of time and the system state. A one-shot delay model in which a single event causes a dynamic failure is considered. The knowledge of hard deadline is applied to the design of error recovery in a triple modular redundant controller computer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
High-Frequency Resonant Inverter for Power Transfer Between Distributed Modules of a Biomedical Implant (2019)

This paper presents a resonant inverter architecture appropriate for wired power transfer between distributed modules of a biomedical implant. The proposed inverter comprises a full-bridge inverter and two T-LCC resonant networks that help generate the required ac output voltage. It is demonstrated that this T-LCC resonant inverter topology can maintain near-constant output voltage across a wide load range without closed-loop control. The proposed inverter can also achieve high efficiency by minimizing circulating currents and maintaining soft-switching across a wide load range. A 130-mW, 1-MHz prototype T-LCC resonant inverter achieves a full-power efficiency of 86% and maintains efficiency above 80% across a two-to-one power range.
Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development (2017)

Airway submucosal glands (SMGs) are facultative stem cell niches for the surface epithelium, but the phenotype of the SMG-derived progenitor cells remains unclear. In other organs, glandular myoepithelial cells (MECs) have been proposed to be multipotent progenitors for luminal cells. We sought to determine the developmental phase during which mouse tracheal glandular MECs are born and whether these MECs are progenitors for other cell phenotypes during SMG morphogenesis. To approach this question, we localized two MEC protein markers (α-smooth muscle actin [αSMA/ACTA2] and smooth muscle myosin heavy chain 11 [SMMHC/MYH11]) during various stages of SMG development (placode, elongation, branching, and differentiation) and used ACTA2-Cre<sup>ERT2</sup> and MYH11-Cre<sup>ERT2</sup> transgenic mice to fate map MEC-derived lineages during SMG morphogenesis. Both αSMA- and SMMHC-expressing cells emerged early after placode formation and during the elongation phase of SMG development. Lineage tracing in newborn mice demonstrated that lineage-positive MECs are born at the tips of invading tubules during the elongation phase of gland development. Lineage-positive MECs born within the first 7 days after birth gave rise to the largest percentage of multipotent progenitors capable of contributing to myoepithelial, serous, mucous, and ductal cell lineages. Serial tamoxifen-induction of both Cre-driver lines demonstrated that lineage-positive multipotent MECs contribute to ∼ 60% of glandular cells by 21 days after birth. In contrast, lineage-traced MECs did not contribute to cell types in the surface airway epithelium. These findings demonstrate that MECs born early during SMG morphogenesis are multipotent progenitors with the capacity to differentiate into other glandular cell types.
Equilibrium Morphology of Face-Centered Cubic Gold Nanoparticles >3 nm and the Shape Changes Induced by Temperature (2005)

Many of the unique properties of metallic nanoparticles are determined not only by their finite size but also by their shape, defined by the crystallographic orientation of the surface facets. These surfaces (and therefore the nanoparticles themselves) may differ in a number of ways, including surface atom densities, electronic structure, bonding, chemical reactivities, and thermodynamic properties. In the case of gold, it is known that the melting temperature of nanoparticles strongly depends on the crystal size and that the shape may alter considerably (and yet somewhat unpredictably) during annealing. In this work we use first principle calculations and a thermodynamic model to investigate the morphology of gold nanoparticles in the range 3-100 nm. The results predict that the equilibrium shape of gold nanoparticles is a modified truncated octahedron and that the (size-dependent) melting of such particles is preceded by a significant change in the nanoparticle's morphology.
Demonstration of a FPGA-Based CPRI-over-Ethernet Real-Time System Achieving 120 Gb/s Throughput over a 10-km SSMF Link with 16 Bi-Directional 10GE Connections (2017)

We experimentally demonstrate a real-time CPRI-over-Ethemet system for mobile fronthaul using four Xilinx Virtex-7 FPGAs. Error-free transmission over a 10-km SSMF link has been achieved with a total throughput of 120 Gb/s and a round-trip processing latency of <20 μs.
ChemInform Abstract: A Disaccharide Polyphosphate Mimic of 1D‐myo‐Inositol 1,4,5‐ Trisphosphate. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The role of the armadillo and sooty mangabey monkey in human leprosy (2008)

Leprosy in armadillos and sooty mangabeys has been manipulated by human experimentation. In the case of the armadillo, further study, including molecular techniques, is required to elucidate the role of the armadillo as a zoonosis in human leprosy. Experimentation with the sooty mangabey led to the discovery of an interaction between SIV and leprosy in rhesus monkeys, and prompted the continued investigation of the relationship between HIV and leprosy.
Multi-Velocity Neural Networks for Facial Expression Recognition in Videos (2017)

We present a new action recognition deep neural network which adaptively learns the best action velocities in addition to the classification. While deep neural networks have reached maturity for image understanding tasks, we are still exploring network topologies and features to handle the richer environment of video clips. Here, we tackle the problem of multiple velocities in action recognition, and provide state-of-the-art results for facial expression recognition, on known and new collected datasets. We further provide the training steps for our semi-supervised network, suited to learn from huge unlabeled datasets with only a fraction of labeled examples.
Supplementary Figure Legend 1, Table Legends 1-3 from Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression (2023)

Supplementary Figure Legend 1, Table Legends 1-3 from Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression
Multilevel Converter for 4.16- and 6.6-kV Variable Speed Drives (2020)

This article presents a new transformerless multilevel converter topology. This power converter is owned by Nidec ASI and is implemented in the medium-voltage drive SILCOVERT-FH. The topology is composed by the series association of two Macro cells, which can be extended in order to increase the number of output levels, and one external selector cell. Among the advantages, the number of devices directly connected in series does not depend on the dc bus voltage. The same devices can be used in 5L and 7L configurations to address the 4.16- and 6.6-kV applications, which is a significant advantage from the industrialization point of view. Moreover, due to its inherent feature, the zero-crossing is performed naturally at zero-voltage switching on the selector cell. Experimental and simulation results are shown in order to validate the performance of the converter, highlighting the main benefits and features of the proposed topology.
Altered linkage pattern of N-glycan sialic acids in pseudomyxoma peritonei (2020)

Pseudomyxoma peritonei (PMP) is a highly mucinous adenocarcinoma growing in the peritoneal cavity and most commonly originating from the appendix. Glycans play an important role in carcinogenesis, and glycosylation is altered in malignant diseases, including PMP. We have previously demonstrated that fucosylation of N-glycans is increased in PMP, but we did not observe modulation of overall sialylation. As sialic acids can be attached to the rest of the glycan via α2,3- or α2,6-linkage, we have now analyzed the linkage patterns of sialic acids in tissue specimens of normal appendices, low-grade appendiceal mucinous neoplasms (LAMN), low-grade (LG) PMP and high-grade (HG) PMP. For the linkage analysis, the enzymatically released acidic N-glycans were first treated with ethyl esterification or α2,3-sialidase digestion followed by MALDI-TOF mass spectrometry. Significant increase in the relative abundance of α2,6-sialylated and decrease in α2,3-sialylated N-glycans was observed in PMP tumors as compared to the normal appendices (P < 0.025). More specifically, increased α2,6-sialylation (P < 0.05) and decreased α2,3-sialylation (P < 0.01) were detected in afucosylated and monofucosylated N-glycans of PMPs, whereas the less abundant multifucosylated glycans, containing terminal fucose, demonstrated increased α2,3-sialylation (P < 0.01). Importantly, the increase in α2,6-sialylation was also detected between PMP and the appendiceal precursor lesion LAMN (P < 0.01). The identified glycosylation alterations produce ligands for sialic acid-binding immunoglobulin-like lectins (Siglecs) and sialofucosylated glycans binding selectins, which play a role in the peritoneal dissemination and progression of the disease.
A Pictorial Approach to Helical Macrostructures in Smectic Liquid Crystals (1997)

Abstract Physical theories concerning the structures and properties of chiral smectic liquid crystals abound, however, very few are of practical use in the design and subsequent synthesis of materials. The development of macroscopic theories, although very useful in the explanation of physical phenomena, are not readily transferable to the microscopic state. Thus, the design of materials depends more on a qualitative approach supported by property-structure correlations than it does on quantitative deliberation. However, viewing the formation and stabilisation of mesophase structures from the microscopic molecular aspect can lead to some very interesting perspectives. In this article, crude or gross molecular shapes are used to investigate local packing arrangements of chiral molecules in layered mesophases. The formation of helical macrostructures is readily described using this form of modelling, and in turn the formation of antiferroelectric and twist grain boundary phases can be rationalised in terms of property-structure correlations. Key Words: Chiralityhelicityferroelectricantiferroelectric liquid crystals
64 EVALUATION OF THE EMIT® MYCOPHENOLIC ACID ASSAY ON THE COBAS MIRA® (1997)

Dias, V. C.; Martens, C.; Zimmermann, L.; Yatscoff, R. W.; LeGatt, D. F. Author Information
Relevance of Endocavitary Structures in Ablation Procedures for Ventricular Tachycardia (2009)

During VT ablation procedures, ECS should be considered for specific mapping and targeted ablation. Once recognized, these structures can be successfully targeted for ablation without valve damage.