gebhart/patrepeval huggingface dataset:
FT-Infrared Spectroscopic Studies of Lymphoma, Lymphoid and Myeloid Leukaemia Cell Lines (2007)

This paper presents a novel method to characterise spectral differences that distinguish leukaemia and lymphoma cell lines. This is based on objective spectral measurements of major cellular biochemical constituents and multivariate spectral processing. Fourier transform infrared (FT-IR) maps of the lymphoma, lymphoid and myeloid leukaemia cell samples were obtained using a Perkin-Elmer Spotlight 300 FT-IR imaging spectrometer. Multivariate statistical techniques incorporating principal component analysis (PCA) and linear discriminant analysis (LDA) were used to construct a mathematical model. This model was validated for reproducibility. Multivariate statistical analysis of FTIR spectra collected for each cell sample permit a combination of unsupervised and supervised methods of distinguishing cell line types. This resulted in the clustering of cell line populations, indicating distinct bio-molecular differences. Major spectral differences were observed in the 4000 to 800 cm−1 spectral region. Bands in the averaged spectra for the cell line were assigned to the major biochemical constituents including; proteins, fatty acids, carbohydrates and nucleic acids. The combination of FT-IR spectroscopy and multivariate statistical analysis provides an important insight into the fundamental spectral differences between the cell lines, which differ according to the cellular biochemical composition. These spectral differences can serve as potential biomarkers for the differentiation of leukaemia and lymphoma cells. Consequently these differences could be used as the basis for developing a spectral method for the detection and identification of haematological malignancies.
Metal oxide catalyzed epitaxy (MOCATAXY) of β-Ga2O3 films in various orientations grown by plasma-assisted molecular beam epitaxy (2020)

In this work, the growth of (010), (001), and 2¯01 β-Ga2O3 by plasma assisted molecular beam epitaxy was investigated. The presence of an indium flux during growth markedly expands the growth regime for β-Ga2O3 across all orientations to higher growth temperatures and growth rates. This metal oxide catalyzed growth allows for similar growth rates of around 5 nm/min across all three orientations, more than twice that of conventional (010) growth and seven times that of (001) growth without indium. Smooth surface morphologies for (010) and (001) β-Ga2O3 were demonstrated, while 2¯01 was significantly rougher. Additionally, doping with Sn was achieved across all orientations and Hall measurements demonstrated higher electron mobility (55 cm2/Vs for a carrier concentration of 3.3 × 1018 cm−3) for (001) β-Ga2O3 grown via metal oxide catalyzed epitaxy than conventional growth.
Total phenolic acids and flavonoid contents determination in Yemeni honey of various floral sources: Folin-Ciocalteu and spectrophotometric approach (2020)

Twenty-nine Yemeni honey samples were analyzed to determine total phenolic and flavonoid contents using Folin-Ciocalteu and spectrophotometric technique. These tested honey samples were collected from different regions corresponding to various floral species: jujube, cactus and multifloral plants. Folin-Ciocalteu method was adopted for the analysis of total phenolic and flavonoid contents. Gallic acid and quercetin were considered as the best standards as the spectrophotometric response of these compounds are equivalent to most other phenolic acids and flavonoid compounds, respectively. The obtained results of honey samples were in a wide range; the highest phenolic acid concentration was obtained for honey produced from cactus, while the lowest value corresponded to monofloral honey from jujube. On the other hand, a broad variation was also observed in total flavonoid content; the highest value was obtained for honey collected from cactus area (S4) and the lowest value was found in honey produced from multifloral plants (A1).
Genetic Mutation of p53 and Suppression of the miR-17∼92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling (2014)

Lung cancer is the leading cause of cancer-related fatalities. Recent success developing genotypically targeted therapies, with potency only in well-defined subpopulations of tumors, suggests a path to improving patient survival. We used a library of oligonucleotide inhibitors of microRNAs, a class of posttranscriptional gene regulators, to identify novel synthetic lethal interactions between miRNA inhibition and molecular mechanisms in non-small cell lung cancer (NSCLC). Two inhibitors, those for miR-92a and miR-1226*, produced a toxicity distribution across a panel of 27 cell lines that correlated with loss of p53 protein expression. Notably, depletion of p53 was sufficient to confer sensitivity to otherwise resistant telomerase-immortalized bronchial epithelial cells. We found that both miR inhibitors cause sequence-specific downregulation of the miR-17∼92 polycistron, and this downregulation was toxic only in the context of p53 loss. Mechanistic studies indicated that the selective toxicity of miR-17∼92 polycistron inactivation was the consequence of derepression of vitamin D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1α,25-dihydroxyvitamin D3 metabolic pathway. Of note, high CYP24A1 expression significantly correlated with poor patient outcome in multiple lung cancer cohorts. Our results indicate that the screening approach used in this study can identify clinically relevant synthetic lethal interactions and that vitamin D receptor agonists may show enhanced efficacy in p53-negative lung cancer patients.
Risk of Progressive Sensorineural Hearing Loss and Meniere's Disease after Breast Implantation (1998)

Our data did not show evidence of a significant relationship between the presence of silicone breast implants and later development of Meniere's disease, progressive sensorineural hearing loss, or positive 68 kD serum.
Production dynamics of Withaferin A inWithania somnifera(L.) Dunal complex (2009)

Withaferin A (WA) is an important withanolide holding promise in cancer treatment and as a relatively safe radiosensitive/chemotherapeutic agent, which is present in traces in all parts of Withania somnifera except the leaves, where as it is reported to be present in only two non-Indian chemotypes (South African chemotype/Israel chemotype 1). The present studies have marked its presence in all Indian populations (wild/cultivated), as well as two identified Indian chemotypes (AGB002 and AGB025). The quantitative dynamics of WA production in Indian populations and interchemotypic hybrids developed at our institute have been studied, and the results were compared with five previously reported chemotypes from Israel, South Africa and India. An analysis on inheritance characteristics based on presence/absence of WA in hybrid plants and their respective parents is given for future studies on the chemogenetics of this complex species in greater detail. Further, the production potential of WA in vitro propagated plants of elite varieties developed at our institute is discussed, in view of maintaining chemotypic fidelity and stability from a production point of view. Also, evidence-based clues suggesting the leaves as the site of the synthesis of WA is provided.
Evaluation of SERS substrates for chemical agent detection (2012)

US Military forces are dependent on indigenous water supplies, which are considered prime targets to effect a chemical or biological attack. Consequently, there is a clear need for a portable analyzer capable of evaluating water supplies prior to use. To this end we have been investigating the use of a portable Raman analyzer with surface-enhanced Raman spectroscopy (SERS) sampling systems. The superior selectivity and exceptional sensitivity of SERS has been demonstrated by the detection of single molecules. However, the extreme sensitivity provided by SERS is attributed to "hot spot" structures, such as particle junctions that can provide as much as 10 orders of magnitude enhancement. Unfortunately, hotspots are not evenly distributed across substrates, which results in enhancements that cannot be quantitatively reproduced. Here we present analysis of uniformity for a newly developed substrate and commercial sample vials using benzenethiol and bispyridylethylene, two chemicals often used to characterize SERS substrates, and methyl phosphonic acid, a major hydrolysis product of the nerve agents.
[Immediate complications of fulguration of ventricular tachycardia and accessory pathways. Analysis of 318 endocavitary shocks]. (1989)

Abnormal events occurring immediately following electric stimulation were studied in 85 patients--mean age 38.5 years (14-78)--during the performance of 318 intracardiac shocks applied in 110 sessions. This electric stimulation was done for treatment of tachycardias related to an accessory pathway (series AP: 64 patients), or ventricular tachycardias (series VT: 21 patients). The number of shocks per session was 2.4 +/- 1.4 and 4.6 +/- 3, for the series AP and VT respectively, and the cumulative energy per session, was 405 +/- 221 J and 1,007 +/- 735 J. Only events occurring within the first 30 minutes following the shocks, were evaluated. In the series AP, the 64 patients received a total of 208 shocks in 86 sessions, and 68 abnormal events were observed (33%): 35 complete atrio-ventricular blocks, of more than 10 seconds (17%), 29 sinus pauses exceeding 3 seconds (14%) and able to stretch to 30 seconds, 3 ventricular fibrillations (1.4%) and 1 atrial fibrillation. In the series TV, 21 patients received 110 shocks in 24 sessions, and only 10 abnormal events occurred (9%): 2 transient episodes of electromechanical dissociation (1.8%), 3 uniform VT (2.7%), 1 complete atrio-ventricular block (10 min.), 1 cardiac pause (4 sec), 1 ventricular fibrillation, 1 isolated haemodynamic depression and 1 Prinzmetal syndrome. All these events were temporary, 5 ventricular arrhythmias in 6 were treated with a new intracardiac shock, and there were no deaths related to electric stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of final drawing with light reduction on the levelling of residual stress distribution in cold bar drawing (2000)

A method is proposed for producing a significant reduction in the magnitude of the residual stress generated after cold drawing of a bar. It consists basically of a skin pass at the final stage of drawing and has a good levelling effect on the residual stress distribution as long as the final reduction falls within a specific range. The method was first proposed as a result of elastic-plastic finite element analyses using the ELFEN code developed by Rockfield Software Limited at the University of Wales, Swansea. The validity of the proposed method was verified by measuring the residual stress using the Sachs method.
Black fluorescent ink and applications (2006)

Black fluorescent inks developed for postal applications exhibit contrast suitable for machine reading and fluorescence suitable for postal processing. The combination of black color and red fluorescence in one ink requires inhibition of fluorescence quenching. One way to inhibit quenching is by combining subtractive dyes and leaving an absorbance window for the emission of the red fluorescence. The absorbance and emission spectra of the ink confirm the model. Another approach is combining larger size colorants: fluorescent and non fluorescent in order to lower the collision probability and quenching by energy transfer. The covert nature of the fluorescence lends itself to security applications.
A 2x2-aperture 4-tap multi-modal tissue imager for multi-band SFDI and MELSCI (2022)

We demonstrate simultaneous multi-band spatial frequency domain imaging (SFDI) and blood flow mapping by multi-exposure laser speckle contrast imaging (MELSCI) with a laboratory-designed 2x2-aperture 4-tap CMOS image sensor. The proposed imaging device is composed of an array of sub-image sensors. This multi-aperture configuration realizes multi-wavelength imaging to estimate chromophore concentrations and wavelength-division-multiplexed imaging for multi-band SFDI and MELSCI. For SFDI, 450, 550, 660nm LEDs were used as the light sources of a DMD. For MELSCI, a 785nm LD was used for flood illumination. Reflectance and K2 maps of a human arm before and after an exercise was measured.
A reconfigurable test platform to experiment with wireless heterogeneous networks in a laboratory (2010)

A large number of wireless technologies and networks have been introduced in the telecommunication world during the last few years. Many protocols and applications (e.g., TCP, VoIP) are not specifically designed for such a variety of wireless protocols; therefore they require a deeper analysis to understand their behaviour over those radio protocols. Performance analysis in close-to-real environment represents a valid method to evaluate and model the behaviour of such protocols and applications for their improvement. This paper presents a wireless heterogeneous testbed that allows experimentation of WLANs and cellular networks in a laboratory. The paper describes also the assessment and the calibration of the testbed. It presents an extensive comparison with a commercial 3G network. Finally, the paper also presents two case studies in order to highlight the benefits of conducting experimental research in an in-lab fully controlled platform.
Self-Assembly of Aβ(10-35)-PEG Block Copolymer Fibrils (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelf-Assembly of Aβ(10-35)-PEG Block Copolymer FibrilsTimothy S. Burkoth, Tammie L. S. Benzinger, Volker Urban, David G. Lynn, Stephen C. Meredith, and P. ThiyagarajanView Author Information Departments of Chemistry and Pathology The University of Chicago, Chicago, Illinois 60637-1043 Intense Pulse Neutron Source, Argonne National Laboratory Argonne, Illinois 60439 Cite this: J. Am. Chem. Soc. 1999, 121, 32, 7429–7430Publication Date (Web):July 27, 1999Publication History Received19 April 1999Published online27 July 1999Published inissue 1 August 1999https://pubs.acs.org/doi/10.1021/ja991233xhttps://doi.org/10.1021/ja991233xrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views999Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Copolymers,Nanofibers,Nucleic acid structure,Peptides and proteins Get e-Alerts
In situ formation of highly active Ni–Fe based oxygen-evolving electrocatalysts via simple reactive dip-coating (2017)

An extremely simple <italic>in situ</italic> reactive dip-coating method is developed to prepare Ni–Fe based electrocatalysts with good catalytic performance on oxygen evolution comparable to those of state-of-the art precious catalysts.
Cross-Coupled Suspended Stripline Trisection Bandpass Filters with Open-Loop Resonators (2005)

We present two bandpass trisection filters with asymmetrical characteristics in the suspended substrate technology. The open-loop resonators are based on a meandered half-wavelength line topology thus allowing a significant size reduction. The design of these filters follows two steps: A synthesis based on the extraction of the general cross-coupled folded network parameters and coupling matrix, then the relationship between the resonators' spacings and coupling coefficients is obtained thanks to full-wave electromagnetic simulations. Transmission zeros on both sides of the passband can be achieved.
Predictions for Future Human Influenza Pandemics (1997)

Will there be another human influenza pandemic? The certainty is that there will be, and the probability is that the virus will emerge from Eurasian aquatic bird reservoirs and involve reassortment between a human and avian strain, with accumulation of mutations or true recombinational events (or both) that will permit spread and pathogenicity among humans. This process will probably occur in pigs because they possess receptors for both avian and human influenza viruses, and emergence may occur in southern China. Prediction of the subtype is impossible, but there is a hypothesis based on seroarcheology that only H1, H2, and H3 subtypes can infect humans; however, it is arguable that H7 or H2 strains might be equally capable of infecting humans.
Pyridocarbazole‐Rhodium(III) Complexes as Protein Kinase Inhibitors (2012)

Abstract Inert metal complexes are sophisticated structural scaffolds for the design of enzyme inhibitors. Whereas previous work from our laboratory was predominantly based on ruthenium(II), this study evaluates the suitability of rhodium in the +3 oxidation state to serve as a structural centre for the design of inert metal‐based enzyme inhibitors. Based on our established staurosporine‐inspired metallo‐pyridocarbazole scaffold, strategies for the convenient synthesis of rhodium(III)‐pyridocarbazole complexes were developed and applied to the synthesis of protein kinase inhibitors. The structures of several rhodium complexes were investigated by X‐ray crystallography. A stability study confirmed the high kinetic inertness of such rhodium complexes under biologically relevant conditions, such as the presence of millimolar concentrations of thiols. Finally, an extremely potent, picomolar rhodium inhibitor for the protein kinase Pim1 was discovered. Thus, it can be concluded that rhodium(III) expands the toolbox for the design of inert metal complexes with biological activity.
Study of energy transfers at the substrate during “transition steps” in magnetron sputter deposition (2014)

International audience
Multiple metal-carbon bonds. 6. The reaction of niobium and tantalum neopentylidene complexes with simple olefins: a route to metallocyclopentanes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 6. The reaction of niobium and tantalum neopentylidene complexes with simple olefins: a route to metallocyclopentanesS. J. McLain, C. D. Wood, and R. R. SchrockCite this: J. Am. Chem. Soc. 1977, 99, 10, 3519–3520Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00452a064https://doi.org/10.1021/ja00452a064research-articleACS PublicationsRequest reuse permissionsArticle Views392Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Physical adsorption of xenon in open single walled carbon nanotubes: Observation of a quasi-one-dimensional confined Xe phase (2000)

The adsorption of Xe into carbon single walled nanotubes with both closed and open ends has been investigated using temperature programmed desorption and other surface analytical tools. It has been found that opening the ends of the nanotube by chemical cutting increases both the kinetic rate and the saturation capacity of the nanotubes for Xe at 95 K. Further enhancement in Xe adsorption kinetics and capacity are achieved by treating the nanotubes in vacuum at 1073 K where CO, CO2, CH4, and H2 are evolved. On this basis it is postulated that surface functionalities such as −COOH block entry ports for adsorption at the nanotube ends and at the defect sites on the walls. The thermal destruction of these functionalities leads to enhanced adsorption. The denser phase of Xe inside the saturated nanotubes desorbs by zero-order kinetics (Ed=26.8±0.6 kJ/mol). It is postulated that a quasi-one-dimensional Xe confined phase in equilibrium, with a two-dimensional Xe gas phase on the exterior, provides a phase transition governing the zero-order kinetics desorption process.
Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice (2010)

Although HB-19 treatment failed to prevent the development of spontaneous melanoma in the RET mice, it delayed for several months the onset and frequency of cutaneous tumors, and exerted a significant inhibitory effect on visceral metastasis. Consequently, HB-19 could provide a novel therapeutic agent by itself or as an adjuvant therapy in association with current therapeutic interventions on a virulent cancer like melanoma.
A rat model to study choroidal blood flow (2009)

Abstract Purpose To develop a model for the investigation of blood flow of in the choroid of rats. Due to their similarities in ocular blood supply und availability, rats are becoming increasingly interesting models in ocular blood flow research. The ability of choroidal autoregulation during changes in perfusion pressure has been shown in various species already. The presented study aims to show autoregulation in the choroid in a new model for blood flow measurement in the choroid of rats. Methods Male Brown‐Norway rats were anesthetised with Ketamin Hydrochloride (100 mg/kg) i.p.. A catheder for blood pressure measurement was inserted into the right femoral artery and advanced to the aorta, another catheter was inserted into the right femoral vein for drug administration. Pentobarbital was used to provide adequate anaesthesia for the following procedures, subsequently the animal was respired via a tracheotomy. Endtidal CO2 was kept in the range between 35 – 45 mmHg and airway pressure was limited to 6 cm H2O. A thoracotomy was performed through the 8th intercostal space and a hydraulic occluder was placed around the inferior vena cava just above its passage through the diaphragm. Choroidal blood flow was measured with a custom‐made, non‐invasive laser Doppler Flowmeter. Results Blood pressure was reduced through a mechanical reduction of venous return, typically from 80 mmHg to 20 mmHg. Between 80 and 50 mmHg, blood flow remained virtually constant, between 50 mmHg and 20 mmHg, a linear relationship between blood pressure and blood flow was observed. Conclusion The presented model is appropriate for the investigation of blood flow in the choroid of rats. Autoregulation in the choroid of rats could be demonstrated.