gebhart/patrepeval huggingface dataset:
Dioxins and related environmental contaminants increase TDP-43 levels (2017)

These results provide the first evidence that environmental AHR ligands increase TDP-43, which is the principle pathological protein associated with ALS. These results suggest novel molecular mechanisms through which a variety of prevalent environmental factors might directly contribute to ALS. The widespread distribution of dioxins, PCBs and PAHs is considered to be a risk factor for cancer and autoimmune diseases, but could also be a significant public health concern for ALS.
Multichannel, programmable, microprocessor based strain gauge telemetry system (2002)

The development of improved implantable devices and materials requires knowledge of their in vivo behavior. However, little is known about the actual loads borne by implanted devices in vivo. Direct load measurement would provide extremely valuable information, for the improvement of device designs, and for the rapid rehabilitation of individuals in which devices have been implanted. Multichannel telemetry systems, combined with strain gauges, can provide this information. Ideally, these systems should possess the flexibility that microprocessor based data acquisition can provide; including: programmable, channel specific gain, digital filtering, power conservation through multiplexing, transmission error detection, and programmable sweep rates. To achieve these advances, we have developed a multichannel, microprocessor based strain gauge telemetry system which maintains small size and low power consumption. Our completed transmitters used only four surface mount ICs, were 14 mm by 30 mm in size, and consumed only 2.8 milliamps at 3 volts DC.
Latency- and Hazard-Free Volume Memory Ar chitecture for Direct Volume Rendering (1996)

The computational power required for direct volume rendering like ray-casting or volume ray-tracing can be provided by high­ speed rendering architectures. However the increasing proces­ sor speed makes a performance bottleneck obvious - the vol­ ume memory. This paper describes a volume memory architec­ ture that achieves at least a tenfold speed-up in read-out rate with moderate additional hardware. It has been simulated suc­ cessfully. A multi-level cache system is used with software prefetching and latency hiding. Pre- and postcaches addi­ tionally speed up the read-out rate so that a 5123 data set stored in a single memory module can be rendered at 3.125 Hz.
Correlation of esophageal conductance measurements with aortic and left ventricular diameters and stroke volume (2000)

Esophageal conductance measurements were correlated with hemodynamic events in 9 dogs chronically instrumented for measurement of left ventricular (LV) and aortic pressures, LV short axis and descending aortic diameters, and aortic blood flow. A four-electrode conductance catheter was positioned in the esophagus. Both an internal and an internal/external configuration were examined during anesthesia with hemodilution, pulmonary lavage and dobutamine infusion. LV stroke volume was altered by caval occlusion at each intervention. Stroke conductance was highly correlated to aortic or LV diameters and stroke volume over a range of diameters depending on the electrode configuration. Esophageal conductance measurements are directly influenced by local hemodynamic events adjacent to the site of measurement.
The Vista Variables in the Via Lactea (VVV) ESO Public Survey: Current Status and First Results (2011)

Vista Variables in the Via Lactea (VVV) is an ESO Public Survey that is performing a variability survey of the Galactic bulge and part of the inner disk using ESO's Visible and Infrared Survey Telescope for Astronomy (VISTA). The survey covers 520 deg^2 of sky area in the ZYJHK_S filters, for a total observing time of 1929 hours, including ~ 10^9 point sources and an estimated ~ 10^6 variable stars. Here we describe the current status of the VVV Survey, in addition to a variety of new results based on VVV data, including light curves for variable stars, newly discovered globular clusters, open clusters, and associations. A set of reddening-free indices based on the ZYJHK_S system is also introduced. Finally, we provide an overview of the VVV Templates Project, whose main goal is to derive well-defined light curve templates in the near-IR, for the automated classification of VVV light curves.
Find the real speed limit: FPGA CAD for chip-specific application delay measurement (2017)

Process variation is increasing with each successive technology node, and it has reached the point where the worst-case timing modelling employed by current FPGA CAD tools is significantly underutilizing the available silicon. Previous studies have proposed exploiting FPGA reconfigurability to reduce this underutilization using techniques such as late binding and dynamic voltage scaling. Most of the proposed solutions require the ability to measure the target application's delay on each configured chip. To accurately measure the delay of an application on a certain chip, we must measure the delay of its speed limiting paths on this specific chip. In this paper, we present a variation-aware CAD tool that automatically generates calibration bitstreams to measure the delay of any input application. Our tool identifies the statistically critical paths of the circuit and optimally selects which paths to test such that it minimizes the chances of reporting an optimistic delay, under a constraint on the number of allowed calibration bitstreams. Experimental results across a suite of benchmarks show that with one calibration bitstream we achieve 16× lower probability of reporting an optimistic delay compared to a greedy approach. With three calibration bitstreams, we reduce the probability of optimism to two chips in a million, approximately 6,000 × lower than a greedy approach.
Serving Content with Unknown Demand:the High-Dimensional Regime (2014)

In this paper we look at content placement in the high-dimensional regime: there are n servers, and O(n) distinct types of content. Each server can store and serve O(1) types at any given time. Demands for these content types arrive, and have to be served in an online fashion; over time, there are a total of O(n) of these demands. We consider the algorithmic task of content placement: determining which types of content should be on which server at any given time, in the setting where the demand statistics (i.e. the relative popularity of each type of content) are not known a-priori, but have to be inferred from the very demands we are trying to satisfy. This is the high- dimensional regime because this scaling (everything being O(n)) prevents consistent estimation of demand statistics; it models many modern settings where large numbers of users, servers and videos/webpages interact in this way. We characterize the performance of any scheme that separates learning and placement (i.e. which use a portion of the demands to gain some estimate of the demand statistics, and then uses the same for the remaining demands), showing it is order-wise strictly suboptimal. We then study a simple adaptive scheme - which myopically attempts to store the most recently requested content on idle servers - and show it outperforms schemes that separate learning and placement. Our results also generalize to the setting where the demand statistics change with time. Overall, our results demonstrate that separating the estimation of demand, and the subsequent use of the same, is strictly suboptimal.
Driver behavior characterization using multiple dynamic models (2016)

Incorporating driver behavior information into vehicle control strategies can significantly improve performance of vehicle control systems, such as active safety systems and driver assistance systems. This paper proposes an algorithm for driver behavior characterization based on handling limits. In order to implement the handling limit-based algorithm, an interacting multiple model estimation technique is applied, which accounts for probabilistic correctness of the multiple models. The proposed algorithm is validated through experimental tests, and the results illustrate potential of the proposed algorithm as a stochastic approach for driver behavior characterization based on handling limits.
Three-Dimensional Laser Cooling of Helium Beyond the Single-Photon Recoil Limit (1995)

We report the first observation of subrecoil laser cooling in three dimensions, where we use the method of velocity-selective coherent population trapping. We have cooled a cloud of trapped metastable helium atoms to 180 nK, 22 times below the single-photon recoil temperature, with an enhancement in the momentum-space density of 16. We find that the efficiency with which the velocity-selective trap is populated can be augmented by Sisyphus-type frictional forces, while the cooling process is accompanied by the diffusion of atoms to states of very high velocity.
New developments in fused deposition modeling of ceramics (2005)

Purpose To shift from rapid prototyping (RP) to agile fabrication by broadening the material selection, e.g. using ceramics, hence improving the properties (e.g. mechanical properties) of fused deposition modeling (FDM) products. Design/methodology/approach This paper presents the development of a novel extrusion system, based on the FDM technology. The new set‐up, consisting of a mini‐extruder mounted on a high‐precision positioning system, is fed with bulk material in granulated form, instead that with the more common filament. Findings Previous research showed that the applications of new materials with specific characteristics in a commercial FDM system are limited by the use of intermediate precursors, i.e. a filament. The new design described in this paper overcomes the problem thanks to the new feeding system. Research limitations/implications The work presented in this paper is only the starting point for further development. The new system design was tested and encouraging improvements of the final product were achieved. However, several parameters, e.g. size of the feeding granules, still need to be optimized. Practical implications This configuration opens up opportunities for the use of wider range of materials, making the FDM to become a viable alternative manufacturing process for specialty products. Originality/value The mini‐extruder deposition system developed in this study exploits the advantages of the RP technologies: ability to shorten the product design and development time; suitability for automation; and ability to build many geometrically complex shapes. Hence, applying the described technology, it will be possible to manufacture customer‐driven product with important cost and time (from design to final product) savings.
de.NBI Cloud Storage Tübingen. A federated and georedundant solution for large scientific data (2019)

The »German Network for Bioinformatics Infrastructure«, or in short »de.NBI«, is a national research infrastructure providing bioinformatics services to users in life sciences research, biomedicine and related fields. At five sites across Germany, cloud sites were established to host the bioinformatics services. In Tübingen an extension of the storage capabilites of the cloud was planned, implemented and brought into production. We here report about the motivation, requirements, design decisions and experiences which might serve as inspiration for other large scale storage endeavours in the academic domain.
Immunobiochemical characterization with monoclonal antibodies of Epstein-Barr virus-associated early antigens in chemically induced cells (1984)

Five monoclonal antibodies which are reactive to early antigens of Epstein-Barr virus have been produced by using somatic cell hybridization techniques. The specificity of the monoclonal antibodies to early antigens was demonstrated by indirect immunofluorescence, which showed that the antigens were localized to the nucleus of early antigen-induced Raji cells. Additional indirect immunofluorescence studies showed that like patient antisera to diffuse-staining early antigen, the monoclonal antibodies gave positive staining reactions after methanol fixation. One of the antibodies, 1150-4, was positive by the anti-complement immunofluorescence technique but differed with Epstein-Barr virus-associated nuclear antigen-positive patient sera in that it only stained induced cells. Different fixation methods were found to alter dramatically the appearance of the nuclear staining reactions produced by the monoclonal antibodies. Immunoprecipitation and immunoblot experiments revealed that monoclonal antibodies 1108-1 and 1129-1 recognized two polypeptides of 55,000 and 50,000 daltons (p55;50), 1173-6 and 1180-2 recognized just p50, and 1150-4 identified a 65,000-dalton nuclear protein. Immunobiochemical characterization of these viral antigens showed that p55 is a phosphoprotein, and p55;50 has strong DNA-binding activity preferentially to single-stranded DNA. Elucidation of the role of these nuclear proteins in Epstein-Barr virus infection and the events associated with Epstein-Barr virus-directed lymphocyte transformation may provide significant information on the pathogenicity of this important human virus.
Magnetic Josephson Junction Technology for Digital and Memory Applications (2012)

The lack of dense, fast, energy efficient memory has been the main detractor for multiple superconducting digital projects in the past. Recently, fundamental physics research in superconductor-ferromagnet thin-film tunnel structures created a new opportunity to solve this long-standing problem. Superconductivity and ferromagnetism, two deeply antagonistic electronic properties, can co-exist in form of Magnetic Josephson Junctions (MJJs). The superconducting-ferromagnetic MJJs are electrically compatible with traditional superconductor-insulator-superconductor (SIS) Josephson junctions (JJs) used for digital energy-efficient single flux quantum (eSFQ/ERSFQ) circuits. Both MJJ and JJ circuits have similar fabrication process and can be integrated on a single chip. As a result, a combination of MJJs and JJs can be used to form addressable memory cells, energy-efficient memory periphery circuits and programmable logic elements. In this paper, we present the test results of superconductor-insulator-ferromagnet-superconductor (SIFS) MJJs showing their applicability for superconducting spintronic memory and digital circuits.
New series of sulfonamides containing amino acid moiety act as effective and selective inhibitors of tumor-associated carbonic anhydrase XII (2014)

New benzenesulfonamides incorporating water solubilizing moieties were synthesized using N-α-acetyl-l-lysine or γ-aminobutyric acid as scaffolds followed by the conversion of their terminal amino group to the guanidine one. Their inhibition activity was assessed by determining their KIs values against the human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IX and XII. Some of these compounds were medium potency inhibitors of the cytosolic (CA I, II) and transmembrane (CA IX) isoforms and highly effective, nanomolar inhibitors of the second transmembrane isoform hCA XII. Some of these sulfonamides possessing good selectivity inhibition for the tumor-associated CA XII isoform over the cytosolic and physiologically dominant isoforms CA I and II may be used as tools to develop new anticancer agents.
Fcϵ receptor‐positive cells are a major source of antigen‐induced interIeukin‐4 in spleens of mice infected with Schistosoma mansoni (1993)

When cultured in vitro with either mitogen or parasite antigens, spleen cells from mice infected with Schistosoma mansoni produce significantly higher levels of IL-4 than splenocytes from control animals. Previous studies suggested that this increase in IL-4 production occurs because of a selective expansion of T helper type 2 (Th2) cells in infected mice. However, these experiments employed unfractionated spleen populations rather than purified T lymphocytes. Here we demonstrate that T-depleted spleen cells from infected animals synthesize high levels of interleukin-4 (IL-4), but no IL-5 when stimulated with parasite antigen in vitro. Nevertheless, when purified by sorting, T cells and non-B, non-T (NBNT) populations produced similar amounts of IL-4 in response to parasite antigen. The IL-4 producing NBNT cells were found to belong to an Fc epsilon receptor (Fc epsilon R)-positive population which after sort purification produced high levels of IL-4 (between 1000 and 2000 U of per 5 x 10(3) cells). FACS analysis revealed that these Fc epsilon R+ cells make up 0.53% of splenic NBNT cells in control animals while in 8-9-week-infected animals they increase to 3.8% of that population. In contrast, in mice with 8-week unisexual worm infections these cells comprise only 1.71% of NBNT cells, indicating that eggs are a major stimulus of the response. The expansion of Fc epsilon R+ cells and their production of IL-4 could be an important factor regulating the selection and induction of different CD4+ subsets in schistosome-infected hosts.
Gold geochemical anomaly in the Cortez district, Nevada (1966)

An area in the Cortez district, Nevada, previously established to be anomalous in arsenic, antimony, and tungsten has been found to be anomalous also in mercury and gold. Samples from narrow quartz veins, calcite veins, and shear zones in partially silicified limestone in the lower plate of the Roberts thrust fault (Cortez window) contain as much as 3.4 ounces gold per ton. The richest samples are from an outcrop, about 100 feet long, surrounded by gravels. Their economic significance is yet to be established.
Gender-specific postnatal demethylation and establishment of epigenetic memory (2015)

DNA methylation patterns are set up in a relatively fixed programmed manner during normal embryonic development and are then stably maintained. Using genome-wide analysis, we discovered a postnatal pathway involving gender-specific demethylation that occurs exclusively in the male liver. This demodification is programmed to take place at tissue-specific enhancer sequences, and our data show that the methylation state at these loci is associated with and appears to play a role in the transcriptional regulation of nearby genes. This process is mediated by the secretion of testosterone at the time of sexual maturity, but the resulting methylation profile is stable and therefore can serve as an epigenetic memory even in the absence of this inducer. These findings add a new dimension to our understanding of the role of DNA methylation in vivo and provide the foundations for deciphering how environment can impact on the epigenetic regulation of genes in general.
Head and Media Design for Curvature Reduction in Heat-Assisted Magnetic Recording (2017)

Recording curvature in magnetic data-storage technology has long been one of the significant challenges impacting on recording performance. Despite curvature occurrence in the conventional recording techniques such as perpendicular magnetic recording (PMR), heat-assisted magnetic recording (HAMR) is demonstrated to induce much more severe curvature than PMR. HAMR curvature could cause poor bit error rate and limits the maximum areal density capacity. Here we have theoretically predicted and demonstrated various approaches for curvature reduction from the aspect of either altering the near-field transducer head design or recording medium design. Optical and thermal modeling have indicated that by utilizing a crown-shape peg to change the thermal source profile and compensate for thermal expansion and rounding effect, it could potentially improve curvature figure of merit (FOM) and achieve curvature reduction by ~45%. In terms of the recording media design, by altering the heat sink and internal layer media material or geometry, it could also achieve curvature cancellation of ~40% with increased thermal gradient. The combined approach from both HAMR head and media perspectives with balanced recording FOMs, could potentially realize significant curvature reduction to be of similar or better recording curvature level to PMR.
[Intra-sellar non-adenomatous expansive process]. (1997)

More than thirty types of tumors in the sellar region can mimic pituitary adenoma on, magnetic resonance imaging. When they exist, clinical manifestations are not necessarily highly contributive to diagnosis. Headache, visual impairment, signs of antepituitary insufficiency or possible dysmenorrhea with galactorrhea attributed to hyperprolactinemia due to compression of the dopaminergic axis are not specific and may be misleading. Clinical signs of diabetes insipidis and polyphagia are however suggestive of non-pituitary tumors. Consequently, high-resolution imaging (MRI) and sometimes particular diagnostic circumstances (post partum for hypophysitis for example, or breast cancer for metastasis) orient the diagnosis. More rarely tumor enlargement, for example in certain germ cell tumors, provides a clue.
Position estimation in induction machines utilizing rotor bar slot harmonics and carrier frequency signal injection (2002)

This paper presents a simple and robust way of utilizing harmonic saliencies for the estimation of rotor position. A carrier frequency voltage excitation is used to produce a carrier frequency current, which contains the desired spatial information. A closed-loop, tracking observer is then used to estimate the rotor position. Due to its reliance on a spatial saliency and carrier frequency signal injection, the technique is very robust over a wide speed range, including low and zero speed.
Time effect on cardiometabolic risk indicators in patients with bipolar disorder: a longitudinal case–control study (2022)

Individuals with bipolar disorder are at increased risk for cardiovascular diseases. Most studies have described increases in cardiometabolic risk indicators (CMRIs) using clinical cut-off values. Further, there are no longitudinal studies on CMRIs. We aimed to investigate continuous measures of CMRIs in individuals with bipolar disorder and controls using both cross-sectional and longitudinal data. We used data from the Swedish St. Göran Bipolar project. Study individuals were examined at baseline and after a median of 6 and 7 years for the control and patient group, respectively. Data were collected December 2005-December 2020. The cohort included 281 individuals with bipolar disorder (mean age 39 years, 59% women) and 114 controls (mean age 38 years, 55% women). Of those, 155 patients and 74 controls also provided follow-up data. At baseline, individuals with bipolar disorder had significantly higher mean values of waist-to-hip ratio (WHR) (β = 0.142, p = 0.001), body mass index (β = 0.150, p = 0.006), plasma triacylglycerol (TAG) (β = 0.218, p < 0.001), total/plasma high-density lipoprotein-cholesterol (TChol/HDL-C) ratio (β = 0.103, p = 0.03), TAG/HDL-C ratio (β = 0.151, p = 0.006), and non-HDL-C (β = 0.168, p = 0.001) than controls. Most CMRIs remained higher in the patient group at follow-up. The difference between patients and controls increased over time for WHR (0.005 unit/year, p < 0.001), and systolic (1.1 mm Hg/year, p = 0.002) and diastolic (0.8 mm Hg/year, p < 0.001) blood pressure. Individuals with bipolar disorder displayed persistently higher levels of nearly all included CMRIs. Over time, a subset of CMRIs worsened in patients relative to controls. This suggests that active measures to counter cardiovascular risk in persons with bipolar disorder should be considered.