gebhart/patrepeval huggingface dataset:
Urinary Epinephrine and Norepinephrine Excretion in Patients with Medullary Thyroid Carcinoma and Their Relatives (1982)

Medullary thyroid carcinoma can arise as a component of multiple endocrine neoplasia (MEN) syndrome which includes adrenal pheochromocytoma. Familial medullary thyroid carcinoma with no association of other components of MEN syndrome is also reported. Epinephrine and norepinephrine excreted in 24 hour urine and/or randomly voided urine were measured for screening of pheochromocytoma in patients with medullary thyroid carcinoma of either the hereditary or sporadic type and in their relatives. Six patients with clinical symptoms and signs suggesting pheochromocytoma had a markedly increased epinephrine and epinephrine/norepinephrine (E/N) ratio and a less dominant increase of norepinephrine in 24 hour urine. The diagnosis of pheochromocytoma was proved later at surgery. Among 10 patients with hereditary medullary thyroid carcinoma without any clinical symptoms and signs for pheochromocytoma, 6 patients had increased epinephrine and E/N ratio and normal norepinephrine, and the remaining 4 had normal epinephrine, norepinephrine and E/N ratio in 24 hour urine. The six patients with increased epinephrine and E/N ratios were regarded as having latent adrenal medullary hyperfunction. The mean ages of the 6 patients with proved pheochromocytoma, the 6 with latent adrenal medullary hyperfunction and the 4 with normal urinary catecholamine fractions were 51.3, 42.5 and 28.5 years, respectively. At least one patient in each family with hereditary medullary thyroid carcinoma had proved pheochromocytoma or latent adrenal medullary hyperfunction, leaving no family with hereditary medullary thyroid carcinoma only. Urinary epinephrine, norepinephrine and E/N ratios in patients with sporadic medullary thyroid carcinoma and relatives of patients with medullary thyroid carcinoma were not higher than those in normal subjects. Measurements of epinephrine and norepinephrine in randomly voided urine are also a valuable and convenient method for the screening of pheochromocytoma in patients with medullary thyroid carcinoma and their relatives, because they gave results similar to those in 24 hour urine.
RiboVision suite for visualization and analysis of ribosomes (2014)

RiboVision is a visualization and analysis tool for the simultaneous display of multiple layers of diverse information on primary (1D), secondary (2D), and three-dimensional (3D) structures of ribosomes. The ribosome is a macromolecular complex containing ribosomal RNA and ribosomal proteins and is a key component of life responsible for the synthesis of proteins in all living organisms. RiboVision is intended for rapid retrieval, analysis, filtering, and display of a variety of ribosomal data. Preloaded information includes 1D, 2D, and 3D structures augmented by base-pairing, base-stacking, and other molecular interactions. RiboVision is preloaded with rRNA secondary structures, rRNA domains and helical structures, phylogeny, crystallographic thermal factors, etc. RiboVision contains structures of ribosomal proteins and a database of their molecular interactions with rRNA. RiboVision contains preloaded structures and data for two bacterial ribosomes (Thermus thermophilus and Escherichia coli), one archaeal ribosome (Haloarcula marismortui), and three eukaryotic ribosomes (Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens). RiboVision revealed several major discrepancies between the 2D and 3D structures of the rRNAs of the small and large subunits (SSU and LSU). Revised structures mapped with a variety of data are available in RiboVision as well as in a public gallery (). RiboVision is designed to allow users to distill complex data quickly and to easily generate publication-quality images of data mapped onto secondary structures. Users can readily import and analyze their own data in the context of other work. This package allows users to import and map data from CSV files directly onto 1D, 2D, and 3D levels of structure. RiboVision has features in rough analogy with web-based map services capable of seamlessly switching the type of data displayed and the resolution or magnification of the display. RiboVision is available at .
Wearable device for remote monitoring of transcutaneous tissue oxygenation (2021)

Wearable devices have found widespread application in recent years as consumer electronics for sports and health tracking. A metric of health which is overlooked in currently available technology is the measurement of oxygen in living tissue, a key component in the cellular energy production. We report on the development of an optical wireless wearable prototype for transcutaneous oxygen monitoring based on the phosphorescence emission of a highly breathable oxygen sensing film. The device is truly wearable, weighs under 20 grams,is completely self-contained, requires no external readout electronics and is highly sensitive to oxygen in the physiological range.
Leukocyte – endothelial cell adhesion induced by ischemia and reperfusion (1993)

Reperfusion of ischemic tissues is associated with an enhanced production of inflammatory mediators, increased rolling, adherence, and emigration of leukocytes in postcapillary venules, and vascular protein leakage. There is a growing body of evidence that the leukocyte--endothelial cell interactions are largely responsible for the microvascular dysfunction induced by ischemia--reperfusion. Oxygen radicals, produced by xanthine oxidase and other enzymes, appear to play an important role in initiating and amplifying the inflammatory response elicited by ischemia--reperfusion, while neutrophilic proteases contribute significantly to the injury response. The magnitude of the inflammatory responses observed during ischemia and reperfusion is also influenced by adhesion forces generated by specific glycoproteins expressed on the surface of granulocytes and microvascular endothelium, as well as shear forces that are generated by the movement of blood within the microcirculation. Manipulation of free-radical production, leukocyte--endothelial cell adhesion, and (or) intravascular shear forces provides an effective means for attenuating the deleterious influences of ischemia--reperfusion on the microvasculature.
Patient Safety Center Organization (2006)

Abstract : With patient safety and improved outcomes as its focus, the Institute for Surgical and Interventional Simulation (ISIS) is dedicated to the training of medical professionals in technical and procedural skills, and research and development of emerging simulation technologies and educational strategies. ISIS is a collaborative Instituted on the University of Washington School of Medicine. It connects fifteen departments within the School of Medicine, the School of Nursing, the Biorobotics Laboratory, the Human Interface Technology Lab, and the Center of Videoendoscopic Surgery. It offers educational opportunities across the spectrum of medicine, including practicing physicians, residents, medical students, nurses, and other medical professions. This model has applicability in civilian and military settings, as expertise from both can be combined into comprehensive simulation programs. ISIS and the Anderson Simulation Center at Madigan Army Medical Center (MAMC) represent an excellent opportunity to demonstrate the benefits of such a relationship.
Metal‐free phthalimide‐labeled peptide nucleic acids for electrochemical biosensing applications (2022)

Abstract Peptide nucleic acids (PNAs) are neutral mimics of natural DNA and RNA biopolymers that have caught the attention of researchers working on the identification of specific sequences of nucleobases in DNA/RNA strands. For this purpose, specific analytical protocols need to be developed to optimize the nucleic acid recognition ability of PNAs, exploiting both the high intrinsic affinity of PNA/DNA(RNA) couples as well as suitable markers, either linked to the PNA backbone or properly interacting with it in the working medium. In this context, the paper reports on phthalimide and 4‐nitrophthalimide as two cheap, metal‐free electroactive markers covalently bound to the pseudo‐peptide backbone of a PNA decamer. After a preliminary characterization of the markers, as such and in PNA conjugates, attention has been moved toward the optimization of the detectability of the labeled PNA decamers in aqueous solutions. Exploiting the potentiometric stripping analysis on hanging mercury drop electrode it has been possible to reach satisfactory detection limits of ca. 10 nM avoiding the use of expensive transition metal complexes as labels and/or of co‐reagents.
DESIGNING SIDEWALKS AND TRAILS FOR ACCESS. PART I OF II: REVIEW OF EXISTING GUIDELINES AND PRACTICES (1999)

People with disabilities make up nearly one-fifth of the population of this country. Their access to public facilities, such as schools, commercial and recreation areas and government offices, is often very limited. This report focuses on how sidewalks and trails can be made accessible and usable by the widest possible segment of the population. Sponsored by the Federal Highway Administration, a project to research existing conditions on sidewalks and trails for people with disabilities was designed in two parts. Part I, covers literature surveys, site surveys and interviews along with the history of accessibility legislation, travel characteristics of the disabled and engineering and construction design practices. Topics include: Disability Rights Legislation, Characteristics of Pedestrians, Planning Processes, Sidewalk Design Guidelines, and Trail Designs.
X-Ray photoelectron spectroscopic study of captodative olefins: electronic structure of α-thio-acrylonitrile derivatives (1985)

J. Riga, J. J. Verbist, S. Mignani, Z. Janousek, R. Merenyi and H. G. Viehe, J. Chem. Soc., Perkin Trans. 2, 1985, 883 DOI: 10.1039/P29850000883
Erschöpfende oxidative Decarbonylierung von Carbonylmetall-Komplexen durch Licht und Sauerstoff: Das Beispiel (η5-C5Me5)ReO3 (1984)

Der Trioxorheniumkomplex 3 – zitronengelb, luftbeständig, kristallin – bildet sich überraschenderweise bei der Photolyse des Tricarbonylrheniumkomplexes 1 in THF. Unter strengem Sauerstoffausschluß entsteht zunächst 2, das (anders als analoge Mangankomplexe) von der Luft zu 3 oxidiert wird.
28.3: Invited Paper : Progress on Phosphorescent OLED Materials (2015)

In this paper, we present the development of phosphorescent host materials, having triplet energy more than 2.5 eV, to sensitize red phosphorescent dopants. Some of the new phosphorescent hosts exhibited lifetimes (T 70 ) of about 40,000h at an initial luminance of 1000 cd/m 2 , with efficiencies as high as 28 cd/A at a driving voltage of about 4.2 V.
Characterization and Optimization of Silicon Nanoparticle Anodes (2016)

Lithium-ion batteries with higher energy and power density are required as power sources. Silicon is very attractive as an anode material for lithium-ion batteries because of its high capacity. Silicon anode has problems, which include the expansion and cracking of silicon particles by electrochemical lithiation. In order to overcome this problem, silicon nanoparticle as an anode material is proposed. Since the silicon nanoparticle can be easily oxidized the influence of oxygen content of silicon particle was investigated. The initial coulombic efficiency of lithium extraction/insertion decreased when the oxygen content increased. It was found that adding of metal elements such as Al, Zr, La, Ca during preparing silicon nanoparticles by a thermal plasma method is effective to decrease the formation of silicon oxide. In particular, a cell with an anode formed from Al adding silicon particles exhibited high power density of 2835 W kg−1 like a capacitor. Conductive agent content gives influence to the performance of the electrode. The choice of a binder is very important to solve the problem of the large capacity fade observed along cycling. Thus, the influences of conductive additive contents and polymer binders of silicon electrodes on the electrochemical performance were investigated.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Cinnamolide and (.+‐.)‐Methylenolactocin ‐ An Approach to Butenolides Using S‐Alkoxycarbonyl Xanthates. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-γ (2012)

The ERRγ is a hypoxia-independent inducer of neoangiogenesis that can promote reparative revascularization.
Generation of transform-limited 32-fs pulses from a self-mode-locked Ti:sapphire laser (1992)

We show that near-transform-limited 32-fs pulses can be generated directly from a self-mode-locked titanium-doped sapphire oscillator. The laser operates at a center wavelength of 813 nm with a bandwidth of 22 nm in a TEM00 mode. Correct choice of the glass for the intracavity prism pair results in improved compensation of group-velocity dispersion, which yields near-transform-limited output pulses. Compensation for group-velocity dispersion in the output coupler and autocorrelator optics is necessary in order to measure this transform-limited pulse width.
Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells (2017)

Emerging evidence from epidemiological studies suggests a link between environmental chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically distinct types of breast cancers, the most lethal phenotypic variant is inflammatory breast cancer (IBC). Overexpression of epidermal growth factor receptors (EGFR/HER2) along with estrogen receptor (ER) negativity is common in IBC tumor cells, which instead of a solid mass present as rapidly proliferating diffuse tumor cell clusters. Our previous studies have demonstrated a role of an adaptive response of increased antioxidants in acquired resistance to EGFR-targeting drugs in IBC. Environmental chemicals are known to induce oxidative stress resulting in perturbations in signal transduction pathways. It is therefore of interest to identify chemicals that can potentiate EGFR mitogenic effects in IBC. Herein, we assessed in ER-negative IBC cells a subset of chemicals from the EPA ToxCast set for their effect on EGFR activation and in multiple cancer phenotypic assays. We demonstrated that endocrine-disrupting chemicals such as bisphenol A (BPA) and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane can increase EGFR/ERK signaling. BPA also caused a corresponding increase in expression of SOD1 and anti-apoptotic Bcl-2, key markers of antioxidant and anti-apoptotic processes. BPA potentiated clonogenic growth and tumor spheroid formation in vitro, reflecting IBC-specific pathological characteristics. Furthermore, we identified that BPA was able to attenuate the inhibitory effect of an EGFR targeted drug in a longer-term anchorage-independent growth assay. These findings provide a potential mechanistic basis for environmental chemicals such as BPA in potentiating a hyperproliferative and death-resistant phenotype in cancer cells by activating mitogenic pathways to which the tumor cells are addicted for survival.
ChemInform Abstract: Inhibition of Herpes Simplex Virus Type 1 Ribonucleotide Reductase by Substituted Tetrapeptide Derivatives. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vortex Fiber Mode Amplitude Estimation (2012)

Fibers that support stable propagation of orbital angular momentum states require novel methods of characterization. We present a method for coherently estimating the mode amplitudes present in such fibers, from near-field intensity measurements.
Advanced low viscosity synthetic passenger vehicle engine oils (1999)

Abstract Premium quality synthetic passenger vehicle engine oils have been marketed by the authors' company since the early 1970s. During this time, the performance benefits of synthetic‐based engine oils have been documented in a wide variety of engine and vehicle tests. The purpose of this paper is to demonstrate that, with the use of synthetic base oils and advanced additive technology, low viscosity oils can be formulated that have high fuel efficiency but which retain superior engine protection and performance reserves. Specifically, two synthetic engine oils, an SAE OW–40 and an SAE OW–30, have been developed that exceed the highest industry standards in both US (AP1)and European (ACEA) fuel economy and durability engine tests. The high quality of this technology is demonstrated in industry‐standard engine and laboratory performance tests, as well as non‐standard tests, such as extended‐length engine tests, vehicle fuel economy tests, high mileage chassis rolls tests, and extended oil drain ‘over‐the‐road’ vehicle tests.
ChemInform Abstract: The Asymmetric Hydrogenation of Enones: Access to a New L‐Menthol Synthesis (2011)

Abstract Review: 47 refs.
Sol-Gel Derived Titanium Carboxylate Thin Films for Optical Detection of Analytes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSol-Gel Derived Titanium Carboxylate Thin Films for Optical Detection of AnalytesDilum D. Dunuwila, B. A. Torgerson, C. K. Chang, and Kris A. BerglundCite this: Anal. Chem. 1994, 66, 17, 2739–2744Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ac00089a022https://doi.org/10.1021/ac00089a022research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
NIMG-44. DSC-MRI FRACTIONAL TUMOR BURDEN VOLUME PREDICTS OVERALL SURVIVAL IN UNMETHYLATED NEWLY DIAGNOSED HIGH GRADE GLIOMA (2022)

Abstract OBJECTIVE Image maps of Fractional Tumor Burden (FTB), derived from dynamic susceptibility contrast (DSC) perfusion MRI, provide clinically meaningful information for glioma treatment management. The goal of this study was to determine if presurgical FTB is predictive of overall survival (OS) in high-grade glioma (HGG) classified according to WHO 2016 criteria. METHODS Standardized relative cerebral blood volume (sRCBV) maps were created and co-registered with T1+C images using Horos (Version 4.0.0) and Imaging Biometrics software (Version 21.05) (Elm Grove, WI). Enhancing tumor volumes were determined from calibrated pre/post T1 difference (dT1) maps. Tissue-validated sRCBV thresholds were used to create FTB class maps within enhancing lesion with red regions (sRCBV &amp;gt; 1.556) indicating a high probability of vascular tumor, blue regions (sRCBV&amp;lt; 1.0) indicating avascular (non-tumor) tissue and yellow representing tissue with a lower probability of vascular tumor. FTB volume fractions (FTBv) for all vascular tumor (sRCBV &amp;gt;1.0) or the most vascular tumor (sRCBV &amp;gt; 1.566) were determined. Subjects were separated by MGMT methylation status. GraphPad Prism statistical software (Version 9.3.1) was used for Kaplan Meier survival analysis at 12 and 24 months with patients stratified by median FTBv. RESULTS Forty-one subjects (23 males, 18 females) with a median age of 59.45 years were included. Median 12-month and overall survival of unmethylated groups stratified by FTBv (rCBV &amp;gt; 1.0) of 8.33cc was 10.69 and 15.35 months (p=.0453; p=.0317). Unmethylated subjects stratified with FTBv (rCBV &amp;gt; 1.566) of 7.13cc had a median survival of 10.69 and 15.20 with short- and long-term survival distinguished at 12 months (p=0.0033), 24 months (p=0.0002) and overall (p=0.0002). No significant difference in survival was found between the methylated subgroups with FTBv (rCBV &amp;gt; 1.0) or FTBv (rCBV &amp;gt; 1.566) stratified analyses. CONCLUSION These results demonstrate that pre-surgical FTBv is predictive of OS in newly diagnosed unmethylated high-grade glioma.
Active Vibration Control of a Deployable Optical Telescope (2008)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
The Use of Prayer by Coronary Artery Bypass Patients (2000)

Little is known about the use of private prayer following coronary artery bypass graft (CABG) surgery. Using information from a computerized database and responses to two questionnaires, this study gathered retrospective information from a sample of CABG patients (N = 151) about post-CABG emotional health, religious activities, social support, and noncardiac chronic conditions. The majority of patients (68%) reported that they used private prayer to cope following CABG. A path model found that the use of prayer to cope was associated with better postoperative emotional health. The predictors of the use of prayer differed across patient age groups. Older patients (over age 65) were more likely to pray if religion were important to them, whereas younger patients (under age 65) were more likely to pray if they had lower incomes, better preoperative health, and more education.