gebhart/patrepeval huggingface dataset:
Effects of estrogen in vivo on coronary vascular resistance in perfused rabbit hearts (1995)

Estrogen or its vehicle was given daily to three groups of ovariectomized rabbits for various lengths of time, after which coronary flow was measured in their isolated perfused hearts. In one group, intramuscular injections of estrogen (40 micrograms/kg) for 7 or 14 days increased coronary flow by 40-50% (P < 0.05). In rabbits given estrogen intramuscularly for 7 days, the coronary flow returned to the basal level within 7 days after the estrogen injections were discontinued. In a second group of animals, intravenous injections of estrogen (10 micrograms/kg) for 4 days increased the coronary flow by 45% (P < 0.01). In a third group, we administered the estrogen transdermally for 4 days, and we measured the plasma estrogen levels at the end of this period. The coronary flow in this group was increased by 52% (P < 0.001), and the plasma estrogen levels ranged from 39 to 800 pg/ml. In all groups of experiments, the increments in coronary flow evoked by estrogen were virtually abolished by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase. We conclude that estrogen regulates coronary blood flow, in part by upregulating nitric oxide synthase in the coronary vasculature.
1607: Longitudinal Evaluation of Molecular PSA Isoforms and Human Glandular Kallikrein 2 in Predicting Biochemical Failure following Radical Prostatectomy (2007)

You have accessJournal of UrologyModerated Poster 50, Tuesday, May 22, 2007, 3:30 - 5:30 pm1 Apr 20071607: Longitudinal Evaluation of Molecular PSA Isoforms and Human Glandular Kallikrein 2 in Predicting Biochemical Failure following Radical Prostatectomy Ruslan Korets, Angel M. Serio, Sven Wenske, Andrew J. Vickers, Ville Vaisanen, Martin Fleisher, Howard I. Scher, Peter T. Scardino, James A. Eastham, and Hans G. Lilja Ruslan KoretsRuslan Korets More articles by this author , Angel M. SerioAngel M. Serio More articles by this author , Sven WenskeSven Wenske More articles by this author , Andrew J. VickersAndrew J. Vickers More articles by this author , Ville VaisanenVille Vaisanen More articles by this author , Martin FleisherMartin Fleisher More articles by this author , Howard I. ScherHoward I. Scher More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , James A. EasthamJames A. Eastham More articles by this author , and Hans G. LiljaHans G. Lilja More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31795-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1607: Longitudinal Evaluation of Molecular PSA Isoforms and Human Glandular Kallikrein 2 in Predicting Biochemical Failure following Radical Prostatectomy." The Journal of Urology, 177(4S), pp. 532–533 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 532-533 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Ruslan Korets More articles by this author Angel M. Serio More articles by this author Sven Wenske More articles by this author Andrew J. Vickers More articles by this author Ville Vaisanen More articles by this author Martin Fleisher More articles by this author Howard I. Scher More articles by this author Peter T. Scardino More articles by this author James A. Eastham More articles by this author Hans G. Lilja More articles by this author Expand All Advertisement PDF downloadLoading ...
Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines. (2002)

Cyclooxygenase-2 (COX-2) is an important cellular target for both therapy and/or prevention of inflammatory disorders and cancer. The advent of selective COX-2 inhibitors now allows a more precise and safer treatment approach. The screening of an array of cancer cell lines for growth inhibitory effects of COX-2-selective and -nonselective inhibitors, including celecoxib (Celebrex) and rofecoxib (Vioxx), produced two unanticipated findings. Firstly, the antiproliferative effects of celecoxib were noted to be of very similar magnitude for both hematopoietic and epithelial cancer cell lines. Most hematopoietic cell lines had no detectable COX-2 expression by reverse transcription-PCR, and none expressed COX-2 protein. In addition, COX-2-negative epithelial lines were found to have IC50s for celecoxib that were very similar to their COX-2+ counterparts. Thus, important antiproliferative effects were observed that were independent of both the cell lineage and COX-2 status. Secondly, it was also observed that COX-2 inhibitor drugs, celecoxib and rofecoxib, with similar COX-2-selectivity and clinical efficacy for inflammatory indications, differed significantly in their in vitro antiproliferative effects on cancer cell lines. IC50s of 35-65 microM were observed for celecoxib across this entire panel of cell lines. Finally, no difference in the mode or degree of cytotoxicity was apparent between cell lines, because similar levels of apoptosis were observed in COX-2+ and -negative cell lines after treatment with celecoxib, with correspondingly lower levels after rofecoxib treatment. These data are important in that they provide the first direct comparison of epithelial and hematopoietic cancer cell lines, as well as a direct comparison of the in vitro anticancer effects of the two clinically available COX-2 inhibitors.
CIMOSFET: A New MOSFET on SiC with a Superior R<sub>on</sub>·Q<sub>gd </sub>Figure of Merit (2015)

A new MOSFET structure named the CIMOSFET (Central Implant MOSFET) has been presented and experimentally confirmed on SiC. The novelty of the CIMOSFET lies in a p-type implant introduced in the middle of the JFET area to shield the oxide interface field from the drain bias. Compared to the commercially available 1200 V SiC DMOSFET, this new concept has significantly reduced the on-resistance (R on ) and gate-drain capacitance (C gd ) simultaneously, produced a record low R on ·Q gd Figure of Merit of 455 mΩ·nC at 25°C, and 700 mΩ·nC at 150°C (~30% of the best data found). Only a 55% increase in R on from 25°C to 150°C has been achieved due to the highly doped drift layer used on the CIMOSFET. Inductive load switching measurements have shown the CIMOSFET exhibits a fast switching performance. The CIMOSFET blocks 1600 V even though its drift doping is higher than that of the conventional DMOSFETs.
Ultrafast nonlinearities in semiconductor laser amplifiers (1994)

The bound-electronic optical nonlinearities in highly excited semiconductors (i.e., semiconductor lasers) have been calculated using a two-parabolic-band model. The nonlinear absorption spectrum is first obtained using a dressed-state formalism taking into account the contributions from two-photon absorption, electronic Raman, and optical Stark effects. The nonlinear refractive index (${\mathit{n}}_{2}$) is then found by performing a Kramers-Kronig transformation on the nonlinear absorption spectrum. It is also shown that the quadratic Stark splitting of the bands leads to a shift in the quasi-Fermi levels, which introduces additional absorptive and refractive nonlinearities. The sign, magnitude, and the current-density dependence of the calculated ${\mathit{n}}_{2}$ agree well with some recently published experimental results for Al-Ga-As and In-Ga-As-P diode lasers.
Sigma receptor ligands attenuate methamphetamine‐induced hyperthermia but do not modulate IL‐1B mRNA expression in select brain regions (2012)

Methamphetamine is one of the most widely abused drugs worldwide, with hyperthermia being a primary cause of death. Methamphetamine‐induced hyperthermia involves a variety of cellular mechanisms, including increases in IL‐1β. Previous studies indicate methamphetamine interacts with sigma receptors and selective sigma receptor ligands attenuate some of the effects of methamphetamine, including hyperthermia. The purpose of the current study was to determine if sigma receptor ligands can attenuate acute increases in body temperature following methamphetamine administration and whether these protective effects occur through modulation of IL‐1β. To evaluate the role of sigma receptors, male, Swiss Webster mice were pretreated with AZ66 or SN79 15 min prior to an acute bolus dose of methamphetamine and body temperatures were recorded for up to 45 min. Acute, bolus administration of methamphetamine caused a significant, dose dependent increase in body temperature, and pretreatment with each of the sigma receptor ligands significantly attenuated methamphetamine‐induced hyperthermia. To determine if these protective effects were related to the modulation of IL‐1β, the mouse striatum, cortex and hypothalamus were collected 45 min after drug administration and evaluated for IL‐1β mRNA expression. Methamphetamine produced a significant increase in IL‐1β mRNA in each of these brain regions; however, sigma receptor ligands failed to attenuate the changes in IL‐1β mRNA expression. It appears that sigma ligands can mitigate methamphetamine‐induced hyperthermia through a different mechanism from that involved in the modulation of IL‐1β mRNA expression. (Supported by NIDA DA013978, DA023205)
ChemInform Abstract: Synthesis of Natural and Modified Trapoxins, Useful Reagents for Exploring Histone Deacetylase Function. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Graph Representation Learning based Vulnerable Target Identification in Ransomware Attacks (2022)

The increased digitization of commercial and consumer workflows, accelerated cloud adoption, and the growing sophistication of cyber criminals have resulted in ransomware emerging as a major threat of cyber attacks in cloud and data services. While research in malware detection can be partially adapted for ransomware, specific ransomware infection patterns can be leveraged to improve the detection efficiency. In this paper, we focus on identifying vulnerable targets in ransomware attacks, aiming to accelerate the ransomware detection process as well as enable better data backup policies design. Specifically, we make three contributions. First, we characterize lexical features and hierarchical file structure features on those ransomware infected files and folders. Second, we model the data backup as an attributed tree graph, learn a new feature representation of the nodes with graph neural networks, and train a classifier based on the new features. Third, with real-world snapshot backup instances, we demonstrate the superior performance of the graph representation learning based approach over several baselines. Compared to the traditional full-scan approaches, our finding suggests that the vulnerable ransomware attack target identification can result in a more efficient ransomware detection process via focused inspection of most vulnerable data in the backups. Our method can also be easily integrated into existing ransomware detection systems for accelerated cyber resiliency.
Tip-enhanced optical spectroscopy (2004)

Spectroscopic methods with high spatial resolution are essential for understanding the physical and chemical properties of nanoscale materials including biological proteins, quantum structures and nanocomposite materials. In this paper, we describe microscopic techniques which rely on the enhanced electric field near a sharp, laser-irradiated metal tip. This confined light-source can be used for the excitation of various optical interactions such as two-photon excited fluorescence or Raman scattering. We study the properties of the enhanced fields and demonstrate fluorescence and Raman imaging with sub-20 nm resolution.
Location of a VIPoma by iodine-123-vasoactive intestinal peptide scintigraphy. (1998)

A major problem in patients with small endocrine tumors is the difficulty in localizing the primary tumor site. Many endocrine tumors possess larger amounts of high affinity vasoactive intestinal peptide (VIP) binding sites compared with normal tissue or blood cells. We used radiolabeled VIP to localize the tumor site in a patient with Verner-Morrison syndrome (VMS). Under octreotide therapy, the VIP levels had declined in this patient, but a tumor site could not be detected by conventional techniques or by radiolabeled octreotide. However, using 123I-VIP, the tumor was detectable in the pancreatic tail. Surgical resection of the tumor was followed by complete remission of the VMS. Expression of VIP binding sites in the tumor was confirmed by a radioreceptor assay and showed cross-competition between VIP and octreotide. The identity of the VIP binding site in the tumor was analyzed by Northern blotting and revealed the expression of somatostatin receptor subtype 3, which binds both somatostatin-14 and VIP with higher affinity than octreotide. Iodine-123-VIP scintigraphy would be an effective tracer to identity the tumor site in VMS patients.
Temperature and gain tuning of plasmonic coherent perfect absorbers (2015)

We experimentally demonstrate temperature-tuned and gain-assisted surface-plasmonic coherent perfect absorbers. In these devices, coherent perfect absorption (CPA) is supported by balancing the absorber's radiative and non-radiative decay rates under thermal tuning of free-electron collision frequency in the Ag layer and optical tuning of the amplification rate in the adjacent dielectric film with optical gain, respectively. The results show that these methods are experimentally feasible and applicable to various CPA configurations.
<title>Ultra-thin silicon-on-sapphire for high-density active-matrix liquid crystal display (AMLCD) drivers</title> (1994)

Single-crystal ultra-thin (&lt; 100 nm) silicon on sapphire (UTSOS) has been fabricated using solid-phase epitaxy and regrowth techniques to produce a high quality semiconductor material on a transparent substrate ideal for active-matrix liquid crystal display (AMLCD) applications. MOS devices fabricated in this material have lower leakages, small thresholds, and higher transconductances than those fabricated in conventional unimproved SOS.
Immunohistochemical analysis of mesothelin protein in lung tissue from <i>FoxN null/Msln</i>(+/+) and <i>FoxN null/Msln</i>(–/–) mice. (2015)

&lt;p&gt;A portion of lung tissues were fixed in 4% paraformaldehyde embedded in paraffin and sectioned 5 to 6 µm in thickness, then stained for MSLN. &lt;b&gt;A–C:&lt;/b&gt; Lung tissue form &lt;i&gt;FoxN null/Msln&lt;/i&gt;(+/+) stained with anti-Msln antibody (A: 100X; B: 200X magnification); or secondary antibody only (C: 100X magnification) as negative control. &lt;b&gt;D–F:&lt;/b&gt; Lung tissue form &lt;i&gt;FoxN null/Msln&lt;/i&gt;(–/–) stained with anti-Msln antibody (D: 100X; E: 200X magnification); or secondary antibody only (F: 100X magnification) as negative control. As expected strong mesothelin expression was detected in the mesothelial cell lining of the lung from &lt;i&gt;FoxN null/Msln&lt;/i&gt;(+/+) mice but no expression in lung from &lt;i&gt;FoxN null/Msln&lt;/i&gt;(–/–) mice.&lt;/p&gt;
Modelling of powder die compaction for press cycle optimization (2016)

A new electromechanical press for fuel pellet manufacturing was built last year in partnership between CEA-Marcoule and ChampalleAlcen. This press was developed to shape pellets in a hot cell via remote handling. It has been qualified to show its robustness and to optimize the compaction cycle, thus obtaining a better sintered pellet profile and limiting damage. We will show you how 400 annular pellets have been produced with good geometry's parameters, based on press settings management. These results are according to a good phenomenological pressing knowledge with Finite Element Modeling calculation. Therefore, during die pressing, a modification in the punch displacement sequence induces fluctuation in the axial distribution of frictional forces. The green pellet stress and density gradients are based on these frictional forces between powder and tool, and between grains in the powder, influencing the shape of the pellet after sintering. The pellet shape and diameter tolerances must be minimized to avoid the need for grinding operations. To find the best parameters for the press settings, which enable optimization, FEM calculations were used and different compaction models compared to give the best calculation/physical trial comparisons. These simulations were then used to predict the impact of different parameters when there is a change in the type of powder and the pellet size, or when the behavior of the press changes during the compaction time. In 2016, it is planned to set up the press in a glove box for UO2 manufacturing qualification based on our simulation methodology, before actual hot cell trials in the future.
Associative memory with fully parallel nearest-Manhattan-distance search for low-power real-time single-chip applications (2004)

A fully-paralled minimum Manhattan-distance search associative memory has been designed in 0.35μm CMOS with 3-metal layers. The nearest-match unit consumes only 1.02mm2, while the chip area is 7.49mm2. The measured winner-search time of this chip, the time to determine the best-matching reference-data word for an input-data word among a database of 128 reference words (5-bit, 16 units), is < 180nsec. This corresponds to a performance requirement of 16 GOPS/mm2, if a 32-bit computer with the same chip area would have to run the same workload. Furthermore the power dissipation of the designed test chip is only about 26.7mW/mm2.
CDMA-Based Analog Network Coding for Underwater Acoustic Sensor Networks (2015)

We propose ANC-CDMA, a CDMA-based analog network coding scheme for underwater acoustic sensor networks (UW-ASNs) that can significantly improve the underwater acoustic channel utilization. First, we analyze a unidirectional multihop network, in which two acoustic nodes separated by two hops are assigned the same code-division channel (i.e., spreading code) to transmit concurrently. The packets transmitted by the two nodes will collide at the intermediate (relay) node. However, we show that, by exploiting a priori information, i.e., the interfered packet previously received from one of the nodes, and applying joint channel estimation through pilot supervision along with a newly designed adaptive RAKE receiver, the relay node can cancel the interference before decoding the packet of interest. We then extend our analysis to a bidirectional network, in which two nodes first concurrently transmit their packets to the relay using the same spreading code. The relay amplifies and forwards the received interfered packet to the two nodes. We show that either node can still decode the packet of interest after equalizing the channel effects introduced during the propagation from the relay to itself and jointly estimating multipath affected channels and suppressing the self-interference signal before applying the adaptive RAKE receiver. The proposed ANC-CDMA scheme is implemented in a testbed based on Teledyne Benthos Telesonar SM-975 underwater modems and tested extensively in Lake LaSalle. Experiments and simulations demonstrate that for a 1-2 dB tradeoff in signal-to-noise ratio (SNR), the proposed scheme can significantly improve the channel utilization of a unidirectional and bidirectional networks by up to 50% and 100%, respectively, compared with conventional multiuser DS-CDMA scheme.
0315 Effects of Mach Number on Impeller Flow Fields In a Transonic Centrifugal Compressor at Near-Surging Conditions (2012)

In order to improve the performance and operating range of centrifugal compressors, it is indispensable to understand unsteady behavior of vortical flows. In this study, the flow fields at different rotational speed in a transonic centrifugal compressor with single splitter blades have been investigated by Detached Eddy Simulation(DES). The simulation showed that the detached shock wave ahead of full blade, which interacts with the tip leakage vortex as well as the suction surface of adjacent full blade, became strong with a rise in rotational speed, so that the shock wave caused the tip leakage vortex breakdown in almost all pitches. Moreover, it was found that early occurrence of the vortex breakdown at higher flow rate led to a reduction in operating range.
Channel Equalization for Multi-Antenna FBMC/OQAM Receivers (2011)

In this paper, the problem of channel equalization in filter bank multicarrier (FBMC) transmission based on the offset quadrature-amplitude modulation (OQAM) subcarrier modulation is addressed. Finite impulse response (FIR) per-subchannel equalizers are derived based on the frequency sampling (FS) approach, both for the single-input multiple-output (SIMO) receive diversity and the multiple-input multiple-output (MIMO) spatially multiplexed FBMC/OQAM systems. The FS design consists of computing the equalizer in the frequency domain at a number of frequency points within a subchannel bandwidth, and based on this, the coefficients of subcarrier-wise equalizers are derived. We evaluate the error rate performance and computational complexity of the proposed scheme for both antenna configurations and compare them with the SIMO/MIMO OFDM equalizers. The results obtained confirm the effectiveness of the proposed technique with channels that exhibit significant frequency selectivity at the subchannel level and show a performance comparable with the optimum minimum mean-square-error equalizer, despite a significantly lower computational complexity. The possibility of tolerating significant subchannel frequency selectivity gives more freedom in the multicarrier system parameterization. For example, it is possible to use significantly wider subcarrier spacing than what is feasible in OFDM, thus relieving various critical design constraints.
Resonance Raman spectroscopy as a probe of the crystallite size of MoS2 nanoparticles (2016)

Irregularly shaped and inorganic fullerene-like MoS 2 compounds were characterized by Resonance Raman spectroscopy using an exciting line at 633 nm. It was shown that the relative intensity of the longitudinal acoustic mode at 226 cm −1 and its overtone strongly depends on the MoS 2 crystallite size but not on the size of the particles made of agglomerated crystallites. This technique appeared as a promising probe to characterize in situ very small crystallites that are not observed by XRD.
Poly(propylenedioxy)thiophene-Based Supercapacitors Operating at Low Temperatures (2010)

A mixture of the ionic liquids 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (EMIBTI) and 1-ethyl-3-methylimidazolium hexafluorophosphate (EMIPF6) was formulated. The thermal properties of the binary mixture were determined by differential scanning calorimetry and cloud point measurement. No evidence of crystallization or phase separation during cooling at was found. The devices constructed in this study were light weight, flexible, and hermetically sealed. These sealed devices proved effective against electrolyte leakage and performance degradation during temperature cycling. The performance of poly(propylenedioxy) thiophene (PProDOT)-based type I supercapacitors using a EMIBTI/EMIPF6 electrolyte mixture was compared to the performance using neat EMIBTI. It was difficult to deposit PProDOT films directly from the ionic liquid mixtures. However, it was possible to deposit PProDOT films from EMIBTI and then assemble and test the devices using the mixture. The low temperature performance of the EMIBTI/EMIPF6 supercapacitors was superior to that of the EMIBTI-based supercapacitors, evidenced by the retention of capacitive behavior below . The high temperature performance of the EMIBTI/EMIPF6 supercapacitors was nearly as good as the EMIBTI-based supercapacitors with 10% loss after at 70% depth of discharge at .