gebhart/patrepeval huggingface dataset:
Stereoselectivity in the catalytic oligomerization of phenylsilane (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselectivity in the catalytic oligomerization of phenylsilaneJohn P. Banovetz, Kevin M. Stein, and Robert M. WaymouthCite this: Organometallics 1991, 10, 10, 3430–3432Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/om00056a009https://doi.org/10.1021/om00056a009research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fault Diagnosis and Fault Tolerant Control with Application on a Wind Turbine Low Speed Shaft Encoder (2015)

In recent years, individual pitch control has been developed for wind turbines, with the purpose of reducing blade and tower loads. Such algorithms depend on reliable sensor information. The azimuth angle sensor, which positions the wind turbine rotor in its rotation, is quite important. This sensor has to be correct as blade pitch actions should be different at different azimuth angle as the wind speed varies within the rotor field due to different phenomena. A scheme detecting faults in this sensor has previously been designed for the application of a high end fault diagnosis and fault tolerant control of wind turbines benchmark model. In this paper, the fault diagnosis scheme is improved and integrated with a fault accommodation scheme which enables and disables the individual pitch algorithm based on the fault detection. In this way, the blade and tower loads are not increased to due and individual pitch control algorithm operating with faulty azimuth angle inputs. The proposed approaches is evaluated on the previously mentioned benchmark model, which is based on the FAST aero-elastic code provided by NREL.
GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage (2020)

Pan-genotype NS5A inhibitors underpin hugely successful hepatitis C virus (HCV) therapy. The discovery of GSK2818713 (<b>13</b>), a nonstructural protein 5A (NS5A) HCV inhibitor characterized by a significantly improved genotype coverage relative to first-generation NS5A inhibitor daclatasvir (DCV), is detailed herein. The SAR analysis revealed cooperative potency effects of the biphenylene, bicyclic pyrrolidine (Aoc), and methyl-threonine structural motifs. Relative to DCV, <b>13</b> improved activity against genotype 1a (gt1a) and gt1b NS5A variants as well as HCV chimeric replicons containing NS5A fragments from genotypes 2-6. Long-term treatment of subgenomic replicons with <b>13</b> potently and durably decreased HCV RNA levels for gt1a, gt2a, and gt3a. These properties, suitable pharmacokinetics, and the lack of cross-resistance resulted in the selection of <b>13</b> as a preclinical candidate.
New Candidate Vaccines against Blood-StagePlasmodium falciparumMalaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1 (2010)

Although merozoite surface protein 1 (MSP-1) is a leading candidate vaccine antigen for blood-stage malaria, its efficacy in clinical trials has been limited in part by antigenic polymorphism and potentially by the inability of protein-in-adjuvant vaccines to induce strong cellular immunity. Here we report the design of novel vectored Plasmodium falciparum vaccines capable of overcoming such limitations. We optimized an antigenic insert comprising the four conserved blocks of MSP-1 fused to tandemly arranged sequences that represent both allelic forms of the dimorphic 42-kDa C-terminal region. Inserts were expressed by adenoviral and poxviral vectors and employed in heterologous prime-boost regimens. Simian adenoviral vectors were used in an effort to circumvent preexisting immunity to human adenoviruses. In preclinical studies these vaccines induced potent cellular immune responses and high-titer antibodies directed against MSP-1. The antibodies induced were found to have growth-inhibitory activity against dimorphic allelic families of P. falciparum. These vectored vaccines should allow assessment in humans of the safety and efficacy of inducing strong cellular as well as cross-strain humoral immunity to P. falciparum MSP-1.
Cerebellum contributes to motor timing and prediction.Behavioral and fMRI study in healthy subjects and patientswith spinocerebellar ataxia. (2005)

Cerebellum contributes to motor timing and prediction.
Behavioral and fMRI study in healthy subjects and patients with
spinocerebellar ataxia type 6 and 8.
Preparation of Monodisperse Nanoparticles by Membrane Emulsification Using Ordered Anodic Porous Alumina and Its Application to Batteries (2021)

高規則性ポーラスアルミナを用いた膜乳化プロセスにより，Liイオン二次電池用の単分散正極活物質微粒子の作製を行った．金属塩とモノマーを溶解した水溶液を分散相として，細孔サイズの均一なポーラスアルミナ膜を介して連続相中に押し出すことにより，サイズの揃った液滴形成を行った後，各液滴を重合固化することで前駆体微粒子を得た．得られた微粒子に，熱処理を行うことで正極活物質微粒子の作製が可能であった．また，得られる微粒子のサイズは，乳化膜として用いるポーラスアルミナの細孔径を変化させることによって制御可能であった．本検討で得られた微粒子を用いて定電流充放電試験を行った結果，各微粒子は正極として機能することが確かめられ，また，微粒子サイズの変化に伴って電池性能も変化する様子が確認された．
Ferroelectric Properties of MBi4Ti4O15 (M = Sr, Pb, Ca) Thin Films (2004)

Abstract Among the ferroelectric bismuth layered perovskites belonging to Aurivillius family, the MBi4Ti4O15 (MBT15, M = Sr, Ca, Pb) thin films have been fabricated by a chemical solution deposition technique, and their structures and ferroelectric properties were investigated in this work. The SrBi4Ti4O15 (SBT15) film fabricated on IrO2 presented the highest remanent polarization (Pr) among the films in this series. It demonstrated a saturated hysteresis loop at 5 V with Pr of 19 μ C/cm2 and coercive field (Ps) of 116 kV/cm. The PbBi4Ti4O15 (PBT15) thin films were selectively controlled in c-axis and off-c-axis orientation on Pt layer by adjusting the annealing condition. The off-c-axis oriented PbBi4Ti4O15 film demonstrated considerably higher Pr (8.7 μ C/cm2) than that of c-axis oriented film (3.7 μ C/cm2). Regardless of grain orientation, however, PBT15 films were not fatigued up to 1010 cycles under 9V application. The CaBi4Ti4O15 (CBT15) thin films were also produced on Pt and IrO2 electrode, respectively, by controlling the annealing condition. The CBT15 film on IrO2 presented higher Pr (∼10.8 μ C/cm2) than that of film (∼ 6.7 μ C/cm2) on Pt. † Present address: Samsung Advanced Institute of Technology, P.O. Box 111, Suwon 440-600, Korea Keywords: Ferroelectriclayered perovskitehysteresis loopfatiguethin filmSrBi4Ti4O15 PbBi4Ti4O15 CaBi4Ti4O15 ACKNOWLEDGMENT This work has been supported by the Ministry of Information & Communication of Korea (Support Project of University ITRC Program supervised by KIPA). Notes † Present address: Samsung Advanced Institute of Technology, P.O. Box 111, Suwon 440-600, Korea
Dimethyl Methylphosphonate Adsorption Capacities and Desorption Energies on Ordered Mesoporous Carbons (2017)

In this study, we determine effective adsorption capacities and desorption energies for DMMP with highly ordered mesoporous carbons (OMCs), 1D cylindrical FDU-15, 3D hexagonal CMK-3, 3D bicontinuous CMK-8, and as a reference, microporous BPL carbon. After exposure to DMMP vapor at room temperature for approximately 70 and 800 h, the adsorption capacity of DMMP for each OMC was generally proportional to the total surface area and pore volume, respectively. Desorption energies of DMMP were determined using a model-free isoconversional method applied to thermogravimetric analysis (TGA) data. Our experiments determined that DMMP saturated carbon will desorb any weakly bound DMMP from pores >2.4 nm at room temperature, and no DMMP will adsorb into pores smaller than 0.5 nm. The calculated desorption energies for high surface coverages, 25% DMMP desorbed from pores ≤2.4 nm, are 68-74 kJ mol<sup>-1</sup>, which is similar to the DMMP heat of vaporization (52 kJ mol<sup>-1</sup>). At lower surface coverages, 80% DMMP desorbed, the DMMP desorption energies from the OMCs are 95-103 kJ mol<sup>-1</sup>. This is overall 20-30 kJ mol<sup>-1</sup> higher in comparison to that of BPL carbon, due to the pore size and diffusion through different porous networks.
Highly reliable multisensor array (MSA) smart transducers (2006)

Many developments in the field of multisensor array (MSA) transducers have taken place in the last few years. Advancements in fabrication technology, such as Micro-Electro-Mechanical Systems (MEMS) and nanotechnology, have made implementation of MSA devices a reality. NASA Kennedy Space Center (KSC) has been developing this type of technology because of the increases in safety, reliability, and performance and the reduction in operational and maintenance costs that can be achieved with these devices. To demonstrate the MSA technology benefits, KSC quantified the relationship between the number of sensors (<i>N</i>) and the associated improvement in sensor life and reliability. A software algorithm was developed to monitor and assess the health of each element and the overall MSA. Furthermore, the software algorithm implemented criteria on how these elements would contribute to the MSA-calculated output to ensure required performance. The hypothesis was that a greater number of statistically independent sensor elements would provide a measurable increase in measurement reliability. A computer simulation was created to answer this question. An array of <i>N</i> sensors underwent random failures in the simulation and a life extension factor (LEF equals the percentage of the life of a single sensor) was calculated by the program. When LEF was plotted as a function of <i>N</i>, a quasiexponential behavior was detected with marginal improvement above <i>N</i> = 30. The hypothesis and follow-on simulation results were then corroborated experimentally. An array composed of eight independent pressure sensors was fabricated. To accelerate sensor life cycle and failure and to simulate degradation over time, the MSA was exposed to an environmental tem-perature of 125°C. Every 24 hours, the experiment's environmental temperature was returned to ambient temperature (27°C), and the outputs of all the MSA sensor elements were measured. Once per week, the MSA calibration was verified at five different pressure points. Results from the experiment correlated with the results obtained in the computer simulation, in which the overall LEF of the MSA transducer was extended. Furthermore, it was concluded that the MSA approach was capable of extending calibration cycle times at least three times when compared to single-element transducers. These characteristics provided not only an increase in sensor reliability but also a reduction in operational and maintenance costs.
Dual glucagon‐like peptide‐1 receptor/glucagon receptor agonist SAR425899 improves beta‐cell function in type 2 diabetes (2019)

After 28 days of treatment, SAR425899 improved postprandial glucose control by significantly enhancing β-cell function and slowing glucose absorption rate.
Long-Term Survival After Mitral Valve Replacement in Children Aged <5 Years (2001)

Background Short- and long-term outcomes after prosthetic mitral valve replacement (MVR) in children aged &lt;5 years are ill-defined and generally perceived as poor. The experience of the Pediatric Cardiac Care Consortium (45 centers, 1982 to 1999) was reviewed. Methods and Results MVR was performed 176 times on 139 patients. Median follow-up was 6.2 years (range 0 to 20 years, 96% complete). Age at initial MVR was 1.9±1.4 years. Complications after initial MVR included heart block requiring pacemaker (16%), endocarditis (6%), thrombosis (3%), and stroke (2%). Patient survival was as follows: 1 year, 79%; 5 years, 75%; and 10 years, 74%. The majority of deaths occurred early after initial MVR, with little late attrition despite repeat MVR and chronic anticoagulation. Among survivors, the 5-year freedom from reoperation was 81%. Age-adjusted multivariable predictors of death include the presence of complete atrioventricular canal (hazard ratio 4.76, 95% CI 1.59 to 14.30), Shone’s syndrome (hazard ratio 3.68, 95% CI 1.14 to 11.89), and increased ratio of prosthetic valve size to patient weight (relative risk 1.77 per mm/kg increment, 95% CI 1.06 to 2.97). Age- and diagnosis-adjusted prosthetic size/weight ratios predicted a 1-year survival of 91% for size/weight ratio 2, 79% for size/weight ratio 3, 61% for size/weight ratio 4, and 37% for size/weight ratio 5. Conclusions Early mortality after MVR can be predicted on the basis of diagnosis and the size/weight ratio. Late mortality is low. These data can assist in choosing between MVR and alternative palliative strategies.
Advanced Current–Voltage Model of Electrical Contacts to GaAs- and Ge-Based Active Silicon Photonic Devices (2023)

A new compact model, incorporating bias-dependent Schottky barrier height (SBH), is developed to precisely describe the forward-biased current–voltage characteristic of electrical contacts to Ge and GaAs layers in active silicon photonic (SiPho) components. This generic model enables direct evaluation of both the contact doping concentration and the effective barrier height of any semiconductor diode with a single-sided Schottky contact. Extracted parameters greatly agree with scanning spreading resistance microscopy (SSRM) results and literature reports. Process variabilities and design impacts were studied, and insights brought by the model enlightens future device improvements to realize Ohmic contacts.
OR08-3 Untargeted Nuclear Receptor-Wide Screening reveals Novel Ligands From the Brain and Gut. (2022)

Abstract The 48-member family of human nuclear receptors (NRs) plays major roles in metabolic homeostasis, immunity, and inflammatory responses, largely under the control of small lipophilic molecule interactions. A critical barrier precluding major breakthroughs in the discovery of new metabolic ligands is a lack of new methods that allow comprehensive mining of the natural metabolome, most of which remains uncharacterized in terms of identity and function. To address this challenge, our group has developed and optimized an NR pulldown and untargeted metabolomics pipeline that can identify novel NR ligands from various complex mixtures, including tissues, fecal samples, microbiotic cultures, environmental waste and compound libraries. In a first proof of concept screen using brain extracts, a novel omega-3 fatty acid ligand was identified using PPARα as bait. 7(S)-HDHA was selectively isolated despite the presence of other more abundant previously published PPARα ligands. Mass spectrometric detection of 7(S)-HDHA in mouse and rat brain, time-resolved FRET analyses, and thermal shift assay results collectively show that 7(S)-HDHA is the strongest activator and highest affinity natural PPARα ligand identified to date. We also show that 7(S)-HDHA activation of PPARα in cortical neurons effectively stimulates neuronal growth and arborization, key measurements of synaptic capacity in neurons. Since many NRs are expressed in or near the gut, and the interplay between NRs and gut-derived metabolites is largely unaddressed, we have since focused the majority of our efforts on intestinal and microbiome extracts. Dozens of new ligands for xenobiotic-sensing receptors have been identified, including fatty acid, phytoestrogen, peptide, and secondary bile acid, with identities soon to be made available in a public database. A subset will be pursued in-house or with collaborators to identify bacterial sources and receptor-based outcomes. Examples of new PPARα, CAR, PXR, and/or RORα ligand-NR interactions and outcomes will be presented. These discoveries will facilitate new directions for drug development, nutritional supplements and probiotic therapies for the prevention and treatment of a wide spectrum of diseases. Presentation: Saturday, June 11, 2022 12:00 p.m. - 12:15 p.m.
Short Lecture “New insights into the mechanism of action and bioavailability of oleocanthal and oleacein from olive oil” (2022)

Oleocanthal (OC) and oleacein (OL) are highly bioactive secoiridoids found in olive oil at elevated concentrations, especially when it is produced from unripe olives (Olea europaea L.). Both compounds have been correlated with strong activities against serious diseases through recent clinical trials. The most important clinical trials have been performed in patients against chronic lymphocytic leukemia [1], against mild cognitive impairment [2] and against platelet aggregation of normal [3] or diabetic patients. Carefully designed nutritional interventions in humans using olive oil with high OC/OL content or olive oil without OC/OL have provided strong evidence about the unique therapeutic role of those compounds. However, both compounds do not actually circulate in the body and cannot be found in any biological fluid. Recent studies have shown that OC and OL react spontaneously with plasma aminoacids like glycine to form new highly bioactive chemical entities like oleoglycine that circulate in the blood and can also reach the brain of experimental animals [4]. During our continuous effort to understand the mechanisms of action of OC/OL, we investigated the reactions of both compounds with aminoacids and peptides found in human plasma. During this study we screened the selectivity and the rate of this reaction, and we discovered new metabolites with unique structures and properties like oleocysteine (1a, b), oleoserine (2a, b) or oleoglutathione (3a, b) ([Fig. 1]). The synthesized metabolites were structurally elucidated using NMR and MS. The obtained results can shed light on the mechanism of action of OC/OL and more significantly explain their bioavailability.
Optimal conditions for high-speed all-optical SOA-based wavelength shifting (1995)

We analyze the system performance of gain-saturated semiconductor optical amplifier (SOA)-based all-optical wavelength shifting with respect to its dynamic characteristics. When considering the risetime, contrast ratio and intersymbol interference, we find that there exists an optimal probe power and wavelength for high-speed wavelength shifting which reduces the power penalty by 3 dB. The minimum power penalties for the data rates of 10 and 20 Gb/s are 25 and 5 dB, respectively. >
Electrical behavior of high impact polystyrene/liquid crystalline polymer blends containing low content of carbon black (2006)

Abstract This article presents a study of the structure and electrical behavior of carbon black (CB) containing immiscible polymer blends. A series of electrically conductive blends of high impact polystyrene (HIPS), liquid crystalline polymer (LCP), and CB was compounded and followed by a capillary rheometer extrusion process or by injection molding. In these immiscible blends, HIPS serves as a low surface tension matrix and LCP as a polar dispersed phase. Shear and elongational flow result in blend morphology consisting of highly elongated and oriented LCP particles dispersed in the HIPS matrix. The enhancement of conductivity in these blends is due to the affinity of CB to LCP and the formation of cocontinuous phase morphology, giving rise to conductive networks. Blends of various compositions were prepared using various processing conditions, emphasizing the relationship between morphology, rheology, and electrical properties. The presence of at least 20 wt % LCP and 2 phr CB under certain processing conditions (mixing sequence and temperature) is necessary to obtain stable resistivity, independent of the studied extrusion shear rate, and low resistivity values. In addition, the processing mode significantly affects the blends' structure and the resultant electrical properties. Hence, injection molding due to high shear rates, elongational flow, and fast cooling results in high structural and electrical anisotropy. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1688–1696, 2006
Dynamic and Static Examinations of the Larynx (2016)

The examination of the larynx is important not only for diagnostic purposes but also for planning the optimal treatment strategy. The usefulness of the laryngeal stroboscope, flexible laryngoscopy and neck computed-tomography, all of which are generally used to examine dysphonia patients is reported.
Antioxidant properties of coenzyme Q10 in food systems (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntioxidant properties of coenzyme Q10 in food systemsPierre. Lambelet, Juerg. Loeliger, Francoise. Saucy, and Umberto. BraccoCite this: J. Agric. Food Chem. 1992, 40, 4, 581–584Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://doi.org/10.1021/jf00016a010RIGHTS & PERMISSIONSArticle Views142Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (471 KB) Get e-Alertsclose Get e-Alerts
Differentiation of Dental Pulp Stem Cells on Gutta-Percha Scaffolds (2016)

Advances in treatment of tooth injury have shown that tooth regeneration from the pulp was a viable alternative of root canal therapy. In this study, we demonstrated that Gutta-percha, nanocomposites primarily used for obturation of the canal, are not cytotoxic and can induce differentiation of dental pulp stem cells (DPSC) in the absence of soluble mediators. Flat scaffolds were obtained by spin coating Si wafers with three Gutta-percha compounds: GuttaCore™, ProTaper™, and Lexicon™. The images of annealed surfaces showed that the nanoparticles were encapsulated, forming surfaces with root mean square (RMS) roughness of 136⁻211 nm. Then, by culturing DPSC on these substrates we found that after some initial difficulty in adhesion, confluent tissues were formed after 21 days. Imaging of the polyisoprene (PI) surfaces showed that biomineral deposition only occurred when dexamethasone was present in the media. Spectra obtained from the minerals was consistent with that of hydroxyapatite (HA). In contrast, HA deposition was observed on all Gutta-percha scaffolds regardless of the presence or absence of dexamethasone, implying that surface roughness may be an enabling factor in the differentiation process. These results indicate that Gutta-percha nanocomposites may be good candidates for pulp regeneration therapy.