gebhart/patrepeval huggingface dataset:
Bragg edge tomography characterization of additively manufactured 316L steel (2022)

In this work we perform a neutron Bragg edge tomography of stainless steel 316L additive manufacturing samples, one as built via standard laser powder bed fusion, and one using the novel three-dimensional (3D) laser shock peening technique. First, we consider conventional attenuation tomography of the two samples by integrating the signal for neutron wavelengths beyond the last Bragg edge, to analyze the bulk density properties of the material. This is used to map defects, such as porosities or cracks, which yield a lower density. Second, we obtain strain maps for each of the tomography projections by tracking the wavelength of the strongest Bragg edge corresponding to the {111} lattice plane family. Algebraic reconstruction techniques are used to obtain volumetric 3D maps of the strain in the bulk of the samples. It is found that not only the volume of the sample where the shock peening treatment was carried out yields a higher bulk density, but also a deep and remarkable compressive strain region. Finally, the analysis of the Bragg edge heights as a function of the projection angle is used to describe qualitatively crystallographic texture properties of the samples.
The Copper‐Catalyzed N‐Arylation of Indoles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
In Vitro Production of Somaclones with Decreased Erucic Acid Content in Indian Mustard [Brassica juncea (Linn.) Czern&Coss] (2021)

<i>Brassica juncea</i> is a crucial cultivated mustard species and principal oilseed crop of India and Madhya Pradesh, grown for diverse vegetables, condiments, and oilseeds. Somaclonal variation was explored as a probable source of additional variability for the manipulation of fatty acids, especially low erucic acid contents that may be valuable for this commercially important plant species. The plantlets regenerated from tissue cultures (R<sub>0</sub>), their R<sub>1</sub> generation and respective parental lines were compared for morpho-physiological traits and fatty acid profile for the probable existence of somaclonal variations. The first putative somaclone derived from genotype CS54 contained 5.48% and 5.52% erucic acid in R<sub>0</sub> and R<sub>1</sub> regenerants, respectively, compared to the mother plant (41.36%). In comparison, the second somaclone acquired from PM30 exhibited a complete absence of erucic acid corresponding to its mother plant (1.07%). These putative somaclones present a source of variation for exploitation in the development of future mustard crops with low erucic acid content.
The tomato Dwarf gene isolated by heterologous transposon tagging encodes the first member of a new cytochrome P450 family. (1996)

To transposon tag the tomato Dwarf (D) gene, a tomato line that carries a T-DNA containing a maize Activator (Ac) transposable element closely linked to D was pollinated with a stock homozygous for the d mutation. Hybrid seedlings were screened for dwarf progeny, and three independent dwarf lines were obtained. Two of these lines showed inheritance of a recessive phenotype similar to that conferred by the extreme dwarf (dx) allele. Variegation for the dwarf phenotype in one of these lines suggested that D had been tagged by Ac. Genomic DNA adjacent to Ac in these two lines was isolated by use of the inverse polymerase chain reaction, and the two insertions mapped approximately 2 kb apart. Partial complementation of d was observed when the corresponding wild-type sequence was used in transformation experiments. A cDNA clone of D was sequenced, and the predicted amino acid sequence has homology to cytochrome P450 enzymes.
Gate oxide integrity issue caused by wall-related process drift in plasma etching (2003)

Different gate oxide loss in polysilicon gate etching has been found when the chamber wall condition changes, which might affect the consistency of device performance in IC production. In this work, the mechanism of wall-related process drift has been studied through etch performance evaluation and plasma diagnostics. The root cause of this issue has been identified as significant plasma property change due to the variation of surface recombination rate, of reactive free radicals with wall condition.
Response of a circular cylinder wake to superharmonic excitation (2001)

A systematic numerical analysis is performed for superharmonic excitations in a wake where a circular cylinder is rotationally oscillated in time. Emphasis is placed on identifying the secondary and tertiary lock-on in the forced wakes. The frequency responses are scrutinized by measuring the lift coefficient ( C L ). A direct numerical simulation has been conducted to portray the unsteady dynamics of wake flows behind a circular cylinder. The Reynolds number based on the diameter is Re = 106, and the forcing magnitude is 0.10 [les ] Ω max [les ] 0.40. The tertiary lock-on is observed, where the shedding frequency ( St 0 ) is one third of the forcing frequency ( S f ), i.e. the 1/3 subharmonic lock-on. The phase shift of C L with respect to the forcing frequency is observed. It is similar to that of the primary lock-on. However, in the secondary superharmonic excitation, modulated oscillations are observed, i.e. the lock-on does not exist. As Ω max increases, St 0 is gradually shifted from the natural shedding frequency ( St * 0 ) to lower values. The magnitudes and phases of S f and St 0 are analysed by the phase diagram. The vorticity contours are employed to examine the vortex formation mode against the forcing conditions.
A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat (2001)

Celecoxib was the first of a new class of nonsteroidal antiinflammatory drugs, the cyclooxygenase-2 (COX-2) specific inhibitors, marketed as having the same antiinflammatory efficacy as other nonsteroidal antiinflammatory drugs without their increased risk of gastrointestinal ulceration. Among the widest uses of nonsteroidal antiinflammatory drugs is in the treatment of acute soft tissue injuries. Although the benefits of celecoxib have been shown when used for rheumatoid arthritis and osteoarthritis, we are unaware of any studies concerning its effect on soft tissues. We used the surgically incised medial collateral ligament of male Sprague-Dawley rats as an experimental model for acute ligament injuries to investigate the effects of celecoxib on ligament healing. Fifty rats underwent surgical transection of the right medial collateral ligament. Postoperatively, half were given celecoxib for the first 6 days of recovery, the other half were not. The animals were sacrificed 14 days after the operation, and both the injured and uninjured medial collateral ligaments were mechanically tested to failure in tension. Celecoxib-treated/injured ligaments were found to have a 32% lower load to failure than untreated/injured ligaments. The results of this study do not support use of cyclooxygenase-2 specific inhibitors in the treatment of ligament injuries.
Phosphate-doped transmission fiber with over 40 THz Raman-gain bandwidth (2002)

We fabricated P-doped silicate fibers, which have two Raman gain peaks at around 13 THz and 40 THz. WDM pumping by semiconductor LDs generates over 40 THz continuous gain bandwidth with two broad gain bands.
P4‐171: Pharmacologic properties of compound‐1, a novel and orally active γ‐secretase modulator, as a therapeutic option for the treatment of Alzheimer's disease (2015)

γ-Secretase inhibitors (GSIs) and Notch-sparing GSIs reduce amyloid-β (Aβ) peptides but rise notch-related or notch-unrelated adverse effects. In this study, we examined the efficacies on Aβ processing and cognitive function, and assessed notch-related or notch-unrelated adverse effects of Compound-1, a novel and orally active compound. Aβ species were measured by ELISA. Aβ plaque was detected by immunohistochemistry. β-C-terminal fragment (β-CTF) of amyloid precursor protein was detected by immunoblotting. A cognitive function was evaluated by novel objective recognition test (NORT). Notch related adverse effect was assessed by quantification of HES1 mRNA and PAS-staining method in mice thymus and intestine, respectively. Compound-1 reduced Aβ40 and Aβ42 but inversely increased Aβ37 in Neuro2A cells thereby maintained total Aβ levels unchanged, suggesting it is a γ-secretase modulator (GSM). In a time course study, Compound-1 (3 and 10 mg/kg) reduced Aβ40 and Aβ42 in tris-soluble fraction and the peak of reduction was approximately 1-3 h after oral administration in C57BL mice. Compound-1 (1, 3 and 10 mg/kg) reduced Aβ40 and Aβ42 dose dependently in Tg2576 mice and a statistical significance was achieved at as low as 1 mg/kg. A chronic treatment of Tg2576 mice for 4 months with regular chow containing Compound-1 (10 and 30 mg/kg/day) significantly reduced both soluble and insoluble Aβ42 and ameliorated cognitive impairment. The effect of Compound-1 (1 and 3 mg/kg) on cognitive impairment was maintained even after drug withdrawal for 1 week after oral administrations for 2 months. LY450139 (30 mg/kg), a GSI, decreased HES1 mRNA expressions in thymus and increased the intensity of PAS-positive area in intestine. These alternations were not observed by Compound-1 at 100 mg/kg which is a 100-fold higher dose than that exerted a significant Aβ reduction. BMS708163, a Notch-sparing GSI, but not Compound-1 showed the APP β-C-terminal fragment accumulation in mouse primary neurons. Although BMS708163 (30 and 100 mg/kg) significantly hampered cognitive function in normal mice by administration for one month, Compound-1 (6 mg/kg) significantly improved the cognitive function. Taken together, Compound-1, a novel and orally active GSM, is a promising molecule for the treatment of pathologies associated with Aβ42/40.
ULTRASOUND MICRO-ELASTOGRAPHY: A NEW IMAGING MODALITY TO PHENOTYPE HYPERTENSION IN RAT MODELS (2007)

New ultrasound imaging methods are proposed to non-invasively characterize the mechanical properties of superficial arteries (MicroNIVE) and kidneys (MicroNIKE) in rodents. In MicroNIVE, the vessel wall is compressed/dilated by the blood flow pulsation, whereas time-sequences of high-resolution radio-frequency (RF) ultrasound data are externally acquired. The kinematics of the vascular tissue, assessed with the Lagrangian Speckle Model Estimator (LSME), provides a strain cartography also known as elastogram. Because the LSME assumes linear elasticity conditions, strain is inversely proportional to stiffness, which is an intermediate phenotype of the hypertension (HT) trait. Results are presented for the common carotid artery of spontaneously hypertensive rats (SHR, n = 5) and control normotensive Brown Norway (BN, n = 5) rats. At 15-weeksold, the SHR rats'carotid artery (4.46 ± 1.79% of strain) was found, on average, stiffer that of the BN's, which exhibited strains of 6.76 ± 1.48% (p < .059). On the other hand, in MicroNIKE, the kidney is externally compressed with the ultrasound probe while time-sequences of high-resolution RF data are acquired. For the purpose of investigating the feasibility of MicroNIKE, a fresh excised kidney from a Recombinant Inbred (RI) rat was investigated. The elastograms, computed with the LSME, clearly exhibited the medulla with distinct mechanical properties. It is concluded that MicroNIVE and MicroNIKE are promising new imaging tools to non-invasively and longitudinally study the impact of targeted genes on vascular tissue remodeling and nephroangiosclerosis in engineered rat models of HT.
On modifications of fundamental radiative processes in near-zero-index\n media of various dimensions (2020)

Spontaneous emission, stimulated emission and absorption are the three\nfundamental radiative processes describing light-matter interactions. Here, we\ntheoretically study the behaviour of these fundamental processes inside an\nunbounded medium exhibiting a vanishingly small refractive index, i.e., a\nnear-zero-index (NZI) host medium. We present a generalized framework to study\nthese processes and find that the spatial dimension of the NZI medium has\nprofound effects on the nature of the fundamental radiative processes. Our\nformalism highlights the role of the number of available optical modes as well\nas the ability of an emitter to couple to these modes as a function of the\ndimension and the class of NZI media. We demonstrate that the fundamental\nradiative processes are inhibited in 3D homogeneous lossless zero index\nmaterials but may be strongly enhanced in a zero index medium of reduced\ndimensionality. Our findings have implications in thermal, nonlinear and\nquantum optics as well as in designing quantum metamaterials at optical or\nmicrowave frequencies.\n
Bis(μ-cobaltoceniumselenolate-1:2κ2 Se:Se)bis[bis(cobaltoceniumselenolate-κSe)mercury(II)] tetrakis(hexafluoridophosphate) acetonitrile disolvate (2021)

The title compound, [Co<sub>6</sub>Hg<sub>2</sub>(C<sub>5</sub>H<sub>5</sub>)<sub>6</sub>(C<sub>5</sub>H<sub>4</sub>Se)<sub>6</sub>](PF<sub>6</sub>)<sub>4</sub>·2CH<sub>3</sub>CN or [Hg<sub>2</sub>(CcSe)<sub>6</sub>][PF<sub>6</sub>]<sub>4</sub>·2CH<sub>3</sub>CN (Cc = C<sub>10</sub>H<sub>9</sub>Co), was obtained as bright-orange needle-shaped crystals. It is a salt containing a tetra-cationic dimercury species with six cobaltoceniumseleno-late ligands, four hexa-fluorido-phosphate counter-ions and two aceto-nitrile solvent mol-ecules. The cation (point group ) has a bi-tetra-hedral {Hg<sub>2</sub>Se<sub>6</sub>} core with two bridging Se atoms and four terminal Se atoms.
COMPUTER NETWORKING TEACHING EXPERIENCES USING COTS ROUTERS AND VIRTUAL ENVIRONMENTS: THE UC3M LABORATORY (2009)

Teaching computer network design and operation is complex due to the distributed nature of its operation, the high number of configuration parameters, the different possible failure modes to which they should cope, etc Experimentation with real equipment is clearly a required step in the learning process, but this usually requires lots of resources, both in terms of equipment and personnel. In this paper, we describe the teaching framework deployed in the Telematics Engineering Department of the University Carlos III of Madrid, based on two main teaching innovations: a) the use of a real laboratory – built using commercial of-the-shelf devices – in which student teams interact with simple scenarios with commercial devices; and b) the use of a virtual laboratory, that provides the flexibility to allow students to focus on more complex problems.
Engineering Calculations and Preparation for Manufacturing of ITER Equatorial Port #11 (2020)

The current integration state of ITER Equatorial Port #11 (EP#11) is described. This port is the first plasma port and thus the integration phase is close to the final stage. The new modular design of neutron shielding is implemented in the Diagnostic shielding modules' (DSM) construction to achieve the maximum shielding efficiency within the weight restrictions and keeping fully operable the tenant diagnostics systems. The same approach was applied to Interspace structure frame design to allow the safe hand-on maintenance near the highly activated components. The current iteration of the engineering calculations, including the neutron transport and shutdown dose rate (SDDR), thermohydraulics, electromagnetics, seismic, and structure integrity calculations, showed that the current design of EP#11 satisfy all ITER requirements. The special metalworking, welding, and various other technologies are tested during the process of preparation for the manufacturing of ITER EP#11. Production technologies of the full-size DSM mock-up and various elements of its infrastructure were tested. The multizoned clean area assembly hall for the final assembly is close to getting completed and the testing of vacuum items has to be sent to ITER.
Pre-transplant Predictors for 3-Month Mortality after Living Donor Liver Transplantation (2014)

Nuri Lee, M.D., Jong Man Kim, M.D., Choon Hyuck David Kwon, M.D., Jae-Won Joh, M.D., Dong Hyun Sinn, M.D., Joon Hyeok Lee, M.D., Mi Sook Gwak, M.D., Seung Woon Paik, M.D. and Suk-Koo Lee, M.D.. J Korean Soc Transplant 2014;28:226-35. https://doi.org/10.4285/jkstn.2014.28.4.226
Application of Optimal Preview Control to Power Plant Cooling Systems (1979)

This paper deals with the application of dynamic control to cooling systems of power plants. The operation of heat dispersal systems with control can result in a saving of power and cooling water. The performance of all cooling systems depends, mainly, upon the ambient conditions and the heat load to be dissipated. Hence, a control scheme that makes use of information obtained by previewing the weather and load conditions, i.e., preview control, is ideally suited for this problem. An iterative procedure is presented for determining the optimal preview control policy for a dynamical system whose dynamics vary depending upon the mode of operation that the controller selects. The algorithm is applied to two types of cooling systems: one consisting of a spray pond and a natural draft wet cooling tower, and the other consisting of a spray pond and a dry cooling tower. The preview control scheme is shown to be a substantial improvement over the uncontrolled case.
Silicon carbide power MOSFETs: Breakthrough performance from 900 V up to 15 kV (2014)

Since Cree, Inc.'s 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> generation 4H-SiC MOSFETs were commercially released with a specific on-resistance (R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON, SP</inf> ) of 5 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a 1200 V-rating in early 2013, we have further optimized the device design and fabrication processes as well as greatly expanded the voltage ratings from 900 V up to 15 kV for a much wider range of high-power, high-frequency, and highvoltage energy-conversion and transmission applications. Using these next-generation SiC MOSFETs, we have now achieved new breakthrough performance for voltage ratings from 900 V up to 15 kV with a R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON, SP</inf> as low as 2.3 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a breakdown voltage (BV) of 1230 V and 900 V-rating, 2.7 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a BV of 1620 V and 1200 V-rating, 3.38 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a BV of 1830 V and 1700 V-rating, 10.6 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a BV of 4160 V and 3300 V-rating, 123 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a BV of 12 kV and 10 kV-rating, and 208 mΩ·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for a BV of 15.5 kV and 15 kV-rating. In addition, due to the lack of current tailing during the bipolar device switching turn-off, the SiC MOSFETs reported in this work exhibit incredibly high frequency switching performance over their silicon counter parts.
Computer-aided design of liposomal drugs: In silico prediction and experimental validation of drug candidates for liposomal remote loading (2020)

Previously we have developed and statistically validated Quantitative Structure Property Relationship (QSPR) models that correlate drugs’ structural, physical and chemical properties as well as experimental conditions with the relative efficiency of remote loading of drugs into liposomes (Cern et al, Journal of Controlled Release, 160(2012) 14–157). Herein, these models have been used to virtually screen a large drug database to identify novel candidate molecules for liposomal drug delivery. Computational hits were considered for experimental validation based on their predicted remote loading efficiency as well as additional considerations such as availability, recommended dose and relevance to the disease. Three compounds were selected for experimental testing which were confirmed to be correctly classified by our previously reported QSPR models developed with Iterative Stochastic Elimination (ISE) and k-nearest neighbors (kNN) approaches. In addition, 10 new molecules with known liposome remote loading efficiency that were not used in QSPR model development were identified in the published literature and employed as an additional model validation set. The external accuracy of the models was found to be as high as 82% or 92%, depending on the model. This study presents the first successful application of QSPR models for the computer-model-driven design of liposomal drugs.
Fucosyltransferase 2 inhibitors: Identification via docking and STD-NMR studies (2021)

Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey. The production of these glycans is increased in various cancers, hence to design and develop specific inhibitors of FUT2 is a therapeutic strategy. The current study was designed to identify the inhibitors for FUT2. In silico screening of 300 synthetic compounds was performed. Molecular docking studies highlighted the interactions of ligands with critical amino acid residues, present in the active site of FUT2. The epitope mapping in ligands was performed using the STD-NMR experiments to identify the interactions between ligands, and receptor protein. Finally, we have identified 5 lead compounds 4, 5, 26, 27, and 28 that can be studied for further development as cancer therapeutic agents.