gebhart/patrepeval huggingface dataset:
Emergency Pancreatoduodenectomy with Preservation of Gastroduodenal Artery for Massive Gastrointestinal Bleeding due to Duodenal Metastasis by Clear Cell Renal Cell Carcinoma in a Patient with Celiac Artery Stenosis (2014)

Duodenal metastasis from renal cell carcinoma is rare, and even rarer is a massive gastrointestinal bleeding from such tumours. Coeliac occlusive disease, although rarely symptomatic, can lead to ischaemic changes with anastomotic dehiscence and leaks when a patient undergoes pancreatoduodenectomy. A 41-year-old man with known metastasis to the adrenal glands and the second part of the duodenum close to the ampulla of Vater from clear cell renal cell carcinoma was admitted to our department due to massive gastrointestinal bleeding from the duodenal metastasis. Endoscopic control of the bleed was not possible, while the bleeding vessel embolization was able to control the haemorrhage only temporarily. An angiography during the embolization demonstrated the presence of stenosis of the coeliac artery and also hypertrophic inferior pancreaticoduodenal arteries supplying the proper hepatic artery via the gastroduodenal artery (GDA). The patient underwent emergency pancreatoduodenectomy with preservation of the gastroduodenal artery. The patient had an uneventful recovery and did not experience further bleeding. Also the blood flow to the liver was compromised as shown by the normal liver function tests (LFTs) postoperatively. To the best of our knowledge, this is the first report of a preservation of the GDA during an emergency pancreatoduodenectomy.
Frequency of del(12p) is commonly underestimated in myelodysplastic syndromes: Results from a German diagnostic study in comparison with an international control group (2015)

In myelodysplastic syndromes (MDS), deletion of the short arm of chromosome 12 (del(12p)) is usually a small abnormality, rarely detected as a single aberration by chromosome banding analysis (CBA) of bone marrow metaphases. Del(12p) has been described in 0.6 to 5% of MDS patients at initial diagnosis and is associated with a good to intermediate prognosis as a sole anomaly according to current scoring systems. Here, we present the results of a systematic del(12p) testing in a German prospective diagnostic study (clinicaltrials.gov: NCT01355913) on 367 MDS patients in whom CD34+ peripheral blood cells were analysed for the presence of del(12p) by sequential fluorescence in situ hybridization (FISH) analyses. A cohort of 2,902 previously published MDS patients diagnosed by CBA served as control. We demonstrate that, using a sensitive FISH technique, 12p deletion occurs significantly more frequently in MDS than previously described (7.6% by CD34+ PB-FISH vs. 1.6% by CBA, P < 0.001) and is often associated with other aberrations (93% by CD34+ PB-FISH vs. 60% by CBA). Additionally, the detection rate can be increased by repeated analyses in a patient over time which is important for the patient´s prognosis to distinguish a sole anomaly from double or complex aberrations. To our knowledge, this is the first study to screen for 12p deletions with a suitable probe for ETV6/TEL in 12p13. Our data suggest that the supplement of a probe for the detection of a 12p deletion to common FISH probe panels helps to avoid missing a del(12p), especially as part of more complex aberrations.
Recent Advances on Pathophysiology, Diagnostic and Therapeutic Insights in Cardiac Dysfunction Induced by Antineoplastic Drugs (2015)

Along with the improvement of survival after cancer, cardiotoxicity due to antineoplastic treatments has emerged as a clinically relevant problem. Potential cardiovascular toxicities due to anticancer agents include QT prolongation and arrhythmias, myocardial ischemia and infarction, hypertension and/or thromboembolism, left ventricular (LV) dysfunction, and heart failure (HF). The latter is variable in severity, may be reversible or irreversible, and can occur soon after or as a delayed consequence of anticancer treatments. In the last decade recent advances have emerged in clinical and pathophysiological aspects of LV dysfunction induced by the most widely used anticancer drugs. In particular, early, sensitive markers of cardiac dysfunction that can predict this form of cardiomyopathy before ejection fraction (EF) is reduced are becoming increasingly important, along with novel therapeutic and cardioprotective strategies, in the attempt of protecting cardiooncologic patients from the development of congestive heart failure.
GraphCast: Learning skillful medium-range global weather forecasting (2022)

Global medium-range weather forecasting is critical to decision-making across many social and economic domains. Traditional numerical weather prediction uses increased compute resources to improve forecast accuracy, but cannot directly use historical weather data to improve the underlying model. We introduce a machine learning-based method called "GraphCast", which can be trained directly from reanalysis data. It predicts hundreds of weather variables, over 10 days at 0.25 degree resolution globally, in under one minute. We show that GraphCast significantly outperforms the most accurate operational deterministic systems on 90% of 1380 verification targets, and its forecasts support better severe event prediction, including tropical cyclones, atmospheric rivers, and extreme temperatures. GraphCast is a key advance in accurate and efficient weather forecasting, and helps realize the promise of machine learning for modeling complex dynamical systems.
Volumetric CT measurement of the ischial tuberosities for designing analytical models of decubitus ulcers (2006)

Decubitus ulcers can have a deleterious effect on the quality of life for some patients, particularly those prone to chronic development of skin ulcerations. The bones of the pelvis are particularly relevant as nearly half of all ulcerations observed in the hospital are in the pelvic region. This research focuses on the development of methods to extract the ischium and adjacent anatomy from volumetric CT data of the pelvis which will be used for patient-specific modeling of high-pressure regions and the treatment of associated ulcers. Six volumetric CT scans were evaluated to determine the size and shape of the ischial tuberosities. Using oblique images computed from the CT data, cross-sectional measurements (approximately Superior-Inferior, Anterior-Posterior, and Left-Right) were made to estimate the size of the ischial tuberosities. Similar measurements were made on the ischial ramus. The mean length of the ischial tuberosities (S-I direction) is 12.35 cm. The mean dimension in the L-R and A-P directions are 2.97 cm and 3.78 cm, respectively. For the ischial ramus, the S-I, L-R, and A-P mean lengths are 6.57 cm, 1.72 cm, and 1.49 cm. Due to a limited field of view for the CT datasets, the thickness of the soft tissue (i.e. Gluteus Maximus and subcutaneous fat) could not be measured. Using the bony measurements and adjacent soft tissue measurements, an investigator would be able estimate the posterior pelvis forces for calculations of pressure on the proximal skin, which could then be used to predict ulcerations in patients, or to design new ulcer-inhibiting seating devices. Current efforts are focused on collecting a large cohort of data with both bony and soft tissue measurements. Future work will incorporate the physical properties of the soft tissue to specifically predict high-pressure regions.
Performance Improvement of Opportunistic Beamforming with Conservative Link Adaptation in the Presence of Channel Estimation Error (2006)

Opportunistic beamforming (OBF) offers a way to provide the multiuser diversity in slow fading channel by using randomly generated beam weights, leading to the substantial reduction of the required feedback from users. In spite of the advantage of the reduced feedback, the imperfect channel estimation might influence the quality of the estimated SNR and channel scheduler so bad that the selected AMC level would be higher than the achievable rate of the actual channel, which is called outage. In this paper, we propose a conservative link adaptation, where the estimated SNR is scaled down by a conservative factor which minimizes the variance of the difference between the actual channel SNR and the resultant SNR. Simulation results show that the introduction of conservative factor shows two-fold performance improvement in the presence of channel estimation error
Supplemental Systemic Oxygen Support Using an Intestinal Intraluminal Membrane Oxygenator (2000)

An intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (FiO2) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O2 content and lower arteriovenous O2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.
Research on flexible display at Ulsan National Institute of Science and Technology (2017)

Abstract Displays represent information visually, so they have become the fundamental building block to visualize the data of current electronics including smartphones. Recently, electronics have been advanced toward flexible and wearable electronics that can be bent, folded, or stretched while maintaining their performance under various deformations. Here, recent advances in research to demonstrate flexible and wearable displays are reviewed. We introduce these results by dividing them into several categories according to the components of the display: active-matrix backplane, touch screen panel, light sources, integrated circuit for fingerprint touch screen panel, and characterization tests; and we also present mechanical tests in nano-meter scale and visual ergonomics research.
Rate-Splitting Multiple Access for Intelligent Reflecting Surface aided Multi-User Communications (2021)

Intelligent reflecting surface (IRS) has recently emerged as a promising technology for 6G wireless systems, due to its capability to reconfigure the wireless propagation environment. In this paper, we investigate a Rate-Splitting Multiple Access (RSMA) for IRS-assisted downlink system, where the base station (BS) communicates with single-antenna users with the help of an IRS. RSMA relies on rate-splitting (RS) at the BS and successive interference cancellation (SIC) at the users and provides a generalized multiple access framework. We derive a new architecture called IRS-RS that leverages the interplay between RS and IRS. For performance analysis, we utilize an \textit{on-off control technique} to control the passive beamforming vector of the IRS-RS and derive the closed-form expressions for outage probability of cell-edge users and near users. Moreover, we also analyze the outage behavior of cell-edge users for a sufficiently large number of reflecting elements. Additionally, we also analyze the outage performance of cooperative RS based decode-and-forward (DF)-assisted framework called DF-RS. Through simulation results, it is shown that the proposed framework outperforms the corresponding DF-RS, RS without IRS and IRS-assisted conventional non-orthogonal multiple access (NOMA) schemes. Furthermore, the impact of various system's parameters such as the number of IRS reflecting elements and the number of users on the system performance is revealed.
Correction: Transgenic Expression of the Dicotyledonous Pattern Recognition Receptor EFR in Rice Leads to Ligand-Dependent Activation of Defense Responses (2015)

Peer-reviewed
Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C (2015)

TM3C is a simple protocol for ascertaining genome architecture and can be used to identify simultaneous contacts among three or four loci. Application of TM3C to a near-haploid human cell line revealed large-scale features of chromosomal organization and multi-way chromatin contacts that preferentially link regions of open chromatin.
Base-Station Duty-Cycling and Traffic Buffering as a Means to Achieve Green Communications (2012)

In this paper, we propose the Base-Station (BS) Discontinuous Transmission (DTX) as the means for saving energy. Traditional proposals utilize DTX at the BS to enable sleep modes under lightly loaded scenarios. However, we propose to shape the traffic to enable more frequent sleep modes at the BS, while ensuring the QoS requirements in terms of application delay are successfully met. The results show that our DTX proposal has a significant potential even under moderately loaded scenarios. The system Energy Efficiency (EE) gain is achieved in our proposal by exploiting the classical Energy-delay tradeoff. We show the performance of our scheme in the presence of realistic system power models proposed within the framework of EARTH project.
Acoustic Impedance Calculation via Numerical Solution of the Inverse Helmholtz Problem (2017)

Assigning homogeneous boundary conditions, such as acoustic impedance, to the thermoviscous wave equations (TWE) derived by transforming the linearized Navier-Stokes equations (LNSE) to the frequency domain yields a so-called Helmholtz solver, whose output is a discrete set of complex eigenfunction and eigenvalue pairs. The proposed method -- the inverse Helmholtz solver (iHS) -- reverses such procedure by returning the value of acoustic impedance at one or more unknown impedance boundaries (IBs) of a given domain via spatial integration of the TWE for a given real-valued frequency with assigned conditions on other boundaries. The iHS procedure is applied to a second-order spatial discretization of the TWEs derived on an unstructured grid with staggered grid arrangement. The momentum equation only is extended to the center of each IB face where pressure and velocity components are co-located and treated as unknowns. One closure condition considered for the iHS is the assignment of the surface gradient of pressure phase over the IBs, corresponding to assigning the shape of the acoustic waveform at the IB. The iHS procedure is carried out independently for each frequency in order to return the complete broadband complex impedance distribution at the IBs in any desired frequency range. The iHS approach is first validated against Rott's theory for both inviscid and viscous, rectangular and circular ducts. The impedance of a geometrically complex toy cavity is then reconstructed and verified against companion full compressible unstructured Navier-Stokes simulations resolving the cavity geometry and one-dimensional impedance test tube calculations based on time-domain impedance boundary conditions (TDIBC). The iHS methodology is also shown to capture thermoacoustic effects, with reconstructed impedance values quantitatively in agreement with thermoacoustic growth rates.
Synthesis and optical properties of Eu3+-doped inorganic–organic hybrid materials based on siloxane networks (2004)

Transparent polydimethylsiloxane–metal oxide (PDMS–MxOy) hybrid materials have been studied as host matrices of Eu3+ ions for their application as optical devices. The versatility of these nanocomposites and the different nature of the metal–oxo domains allow the modulation of the emitting ion coordination and, therefore, of its luminescent response. The optical characterization of Eu3+-doped PDMS–metal oxide hybrid materials (where the metal, M = Al(III), Ge(IV), Sn(IV), Ti(IV), Zr(IV), Nb(V) and Ta(V)) is reported. UV-Vis absorption, excitation and emission spectra, lifetime-resolved measurements, selective excitation experiments and the effect on the optical properties of a post-curing of the doped-nanocomposites are discussed. From the optical results and taking into account the structure of the nanocomposites, the capability of the matrices for encapsulating and dispersing the rare earth ions is analyzed. In this sense, the matrix which contains Ta(V) as cross-linking metal allows the dispersion of the emitting ion in a very effective way, and consequently, its luminescence is highly enhanced (long lifetime value and high emission intensity), even before heat treatment.
<title>Piezoelectric shunt vibration damping of an F-15 panel under high-acoustic excitation</title> (2000)

At last year's SPIE symposium, we reported results of an experiment on structural vibration damping of an F-15 underbelly panel using piezoelectric shunting with five bonded PZT transducers. The panel vibration was induced with an acoustic speaker at an overall sound pressure level (OASPL) of about 90 dB. Amplitude reductions of 13.45 and 10.72 dB were achieved for the first and second modes, respectively, using single- and multiple-mode shunting. It is the purpose of this investigation to extend the passive piezoelectric shunt- damping technique to control structural vibration induced at higher acoustic excitation levels, and to examine the controllability and survivability of the bonded PZT transducers at these high levels. The shunting experiments was performed with the Thermal Acoustic Fatigue Apparatus (TAFA) at the NASA Langley Research Center using the same F-15 underbelly panel. The TAFA is a progressive wave tube facility. The panel was mounted in one wall of the TAFA test section using a specially designed mounting fixture such that the panel was subjected to grazing-incidence acoustic excitation. Five PZT transducers were used with two shunt circuits designed to control the first and second modes of the structure between 200 and 400 Hz. We first determined the values of the shunt inductance and resistance at an OASPL of 130 dB. These values were maintained while we gradually increased the OASPL from 130 to 154 dB in 6-dB steps. During each increment, the frequency response function between accelerometers on the panel and the acoustic excitation measured by microphones, before and after shunting, were recorded. Good response reduction was observed up to the 148dB level. The experiment was stopped at 154 dB due to wire breakage from vibration at a transducer wire joint. The PZT transducers, however, were still bonded well on the panel and survived at this high dB level. We also observed shifting of the frequency peaks toward lower frequency when the OASPL was increased. Detailed experimental results will be presented.
Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly (2007)

The rate of aqueous humor formation sequentially across the pigmented (PE) and nonpigmented (NPE) ciliary epithelial cell layers may not be uniform over the epithelial surface. Because of the tissue's small size and complex geometry, this possibility cannot be readily tested by conventional techniques. Rabbit iris-ciliary bodies were divided, incubated, quick-frozen, cryosectioned, and freeze-dried for electron probe X-ray microanalysis of the elemental contents of the PE and NPE cells. We confirmed that preincubation with ouabain to block Na(+),K(+)-ATPase increases Na(+) and decreases K(+) contents far more anteriorly than posteriorly. The anterior and posterior regions were the iridial portion of the primary ciliary processes and the pars plicata, respectively. Following interruption of gap junctions with heptanol, ouabain produced smaller changes in anterior PE cells, possibly reflecting higher Na(+) or K(+) permeability of anterior NPE cells. Inhibiting Na(+) entry selectively with amiloride, benzamil, or dimethylamiloride reduced anterior effects of ouabain by approximately 50%. Regional dependence of net secretion was also assessed with hypotonic stress, which stimulates ciliary epithelial cell regulatory volume decrease (RVD) and net Cl(-) secretion. In contrast to ouabain's actions, the RVD was far more marked posteriorly than anteriorly. These results suggest that 1) enhanced Na(+) reabsorption anteriorly, likely through Na(+) channels and Na(+)/H(+) exchange, mediates the regional dependence of ouabain's actions; and 2) secretion may proceed primarily posteriorly, with secondary processing and reabsorption anteriorly. Stimulation of anterior reabsorption might provide a novel strategy for reducing net secretion.
Ceramide Generation in Situ Alters Leukocyte Cytoskeletal Organization and β2-Integrin Function and Causes Complete Degranulation (2002)

Ceramide levels increase in activated polymorphonuclear neutrophils, and here we show that endogenous ceramide induced degranulation and superoxide generation and increased surface beta(2)-integrin expression. Ceramide accumulation reveals a bifurcation in integrin function, as it abolished agonist-induced adhesion to planar surfaces, yet had little effect on homotypic aggregation. We increased cellular ceramide content by treating polymorphonuclear neutrophils with sphingomyelinase C and controlled for loss of sphingomyelin by pretreatment with sphingomyelinase D to generate ceramide phosphate, which is not a substrate for sphingomyelinase C. Pretreatment with the latter enzyme blocked all the effects of sphingomyelinase C. Ceramide generation caused a Ca(2+) flux and complete degranulation of both primary and secondary granules and increased surface beta(2)-integrin expression. These integrins were in a nonfunctional state, and subsequent activation with platelet-activating factor or formyl-methionyl-leucyl-phenylalanine induced beta(2)-integrin-dependent homotypic aggregation. However, these cells were completely unable to adhere to surfaces via beta(2)-integrins. This was not due to a defect in the integrins themselves because the active conformation could be achieved by cation switching. Rather, ceramide affected cytoskeletal organization and inside-out signaling, leading to affinity maturation. Cytochalasin D induced the same disparity between aggregation and surface adhesion. We conclude that ceramide affects F-actin rearrangement, leading to massive degranulation, and reveals differences in beta(2)-integrin-mediated adhesive events.
Speech Signal Processing (2018)

The goal of speech coding, or speech compression, is to represent speech in digital form with as few bits as possible while maintaining the intelligibility and quality required for the particular application. Speech and audio coding can be classified according to the bandwidth occupied by the input and the reproduced source. The term intelligibility usually refers to whether the output speech is easily understandable, while the term quality is an indicator of how natural the speech sounds. The mean opinion score (MOS) is an often-used performance measure. To establish a MOS for a coder, listeners are asked to classify the quality of the encoded speech in one of five categories: excellent, good, fair, poor, or bad. The diagnostic acceptability measure developed by Dynastat is an attempt to make the measurement of speech quality more systematic. The MPEG-4 audio coding standard specifies a complete toolbox of compression methods for everything including low bit rate narrowband speech, wideband speech, and high-quality audio.