gebhart/patrepeval huggingface dataset:
The Effect of Anti-Chemokine Oral Drug XC8 on Cough Triggered by The Agonists of TRPA1 But Not TRPV1 Channels in Guinea Pigs (2022)

XC8 acts against cough evoked by the activation of TRPA1 (citric acid/cinnamaldehyde) but not TRPV1 (capsaicin) channels. XC8 inhibits the cough reflex and suppresses the cough potentiation by IFN-γ. XC8 might be of significant therapeutic value for patients suffering from chronic cough associated with inflammation.
Preliminary investigation for application of MEMS acceleration sensor to SF<inf>6</inf> gas circuit breaker (2008)

With an aim of applying a MEMS (Micro Electrical Mechanical System) acceleration sensor as a diagnosis tool for a mechanical degradation of a SF6 gas circuit breaker, we investigated the fundamental characteristics. It is confirmed that the MEMS acceleration sensor with a maximum acceleration number of 250G and a frequency band width up to 400Hz can be applied to measure an acceleration number of the model GCB, while all tests were carried out under no electromagnetic stresses on the GCB. In addition an optical acceleration sensor by using a photo-reflector was developed to be applied in a severe electromagnetic field. The first model of the optical sensor showed insufficient frequency band width for the purpose.
Structure-activity relationships of C-terminal tri- and tetrapeptide fragments that inhibit gastrin activity (1985)

A series of tri- and tetrapeptide derivatives, analogues of the gastrin C-terminal region with no phenylalanine residue, were synthesized. These peptides were tested for their ability to inhibit gastrin-stimulated acid secretion in vivo as well as binding of [125I]-(Nle11)-HG-13 to gastric mucosal cell receptors in vitro. Most of the peptides tested exhibited gastrin antagonist activity in vivo and in vitro. Most active derivatives were 20-30 times more potent than the well-known gastrin antagonist derivatives proglumide and benzotript and had 20-200 times more binding affinity. The smallest fragment exhibiting antagonist activity was the tripeptide Boc-L-tryptophyl-L-methionyl-L-aspartic acid amide.
Test Results of the PEFP 3MeV RFQ Upgrade (2006)

A 3MeV RFQ for 100MeV proton accelerator has been developed at PEFP (Proton Engineering Frontier Project). The tuning results of the cavity showed that both the frequency and field profile were beyond the tuner limit. To check the cavity characteristics, RF test including proton beam acceleration has been done. To solve the problems in existing RFQ, new RFQ so called RFQ Upgrade has been fabricated. Because the main problem of the existing one is improper tuning of the cavity, the important step for development of RFQ Upgrade is to adjust the vanes before brazing. In this paper, the test results of the existing PEFP RFQ and the pre-brazing tuning are presented.
Identification of Chronic Hepatitis B Patients without Significant Liver Fibrosis by a Simple Noninvasive Predictive Model (2005)

Our noninvasive model comprising BMI and three routine laboratory tests was accurate in predicting absence of significant fibrosis. Application of this model could provide useful additional information on the stage of disease, guide future management decisions, and potentially decrease the need for liver biopsy in some CHB patients.
Significant suppression of surface leakage in GaSb/AlAsSb heterostructure with Al 2 O 3 passivation (2019)

Abstract This work develops a (NH 4 ) 2 S/Al 2 O 3 passivation technique for photodiode-based GaSb/AlAsSb heterostructure. Surface-sulfurated GaSb/AlAsSb heterostructure mesas show a significant suppression of reversed-bias dark current by 4–5 orders of magnitude after they are further passivated by Al 2 O 3 layers. So the mesa sidewalls treated with (NH 4 ) 2 S/Al 2 O 3 layers can effectively inhibit the shunt path of dark carriers. The activation energies for both bulk and surface components are extracted from temperature-dependent current–voltage characteristics, which suggest that the bulk characteristics remain unchanged, while Fermi-level pinning at surfaces is alleviated. Additionally, temperature coefficients of the breakdown voltage are extracted, confirming that the breakdown process is confined entirely in the large bandgap AlAsSb regions. This study shows that the implementation of (NH 4 ) 2 S/Al 2 O 3 passivation can lead to room temperature GaSb-based photodiodes and GaSb/AlAsSb-based avalanche photodiodes for highly efficient photodetection.
Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation (2013)

Epithelial organ morphogenesis involves reciprocal interactions between epithelial and mesenchymal cell types to balance progenitor cell retention and expansion with cell differentiation for evolution of tissue architecture. Underlying submandibular salivary gland branching morphogenesis is the regulated proliferation and differentiation of perhaps several progenitor cell populations, which have not been characterized throughout development, and yet are critical for understanding organ development, regeneration, and disease. Here we applied a serial multiplexed fluorescent immunohistochemistry technology to map the progressive refinement of the epithelial and mesenchymal cell populations throughout development from embryonic day 14 through postnatal day 20. Using computational single cell analysis methods, we simultaneously mapped the evolving temporal and spatial location of epithelial cells expressing subsets of differentiation and progenitor markers throughout salivary gland development. We mapped epithelial cell differentiation markers, including aquaporin 5, PSP, SABPA, and mucin 10 (acinar cells); cytokeratin 7 (ductal cells); and smooth muscle α-actin (myoepithelial cells) and epithelial progenitor cell markers, cytokeratin 5 and c-kit. We used pairwise correlation and visual mapping of the cells in multiplexed images to quantify the number of single- and double-positive cells expressing these differentiation and progenitor markers at each developmental stage. We identified smooth muscle α-actin as a putative early myoepithelial progenitor marker that is expressed in cytokeratin 5-negative cells. Additionally, our results reveal dynamic expansion and redistributions of c-kit- and K5-positive progenitor cell populations throughout development and in postnatal glands. The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis.
Autoimmune Polyendocrine Syndrome Type 1 : NALP5 in Autoimmune Polyendocrine Syndrome Type 1 (2006)

Background Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent studies concerning AIRE def ...
A New Method of Ground Fault Location in 2 × 25 kV Railway Power Supply Systems (2017)

Owing to the installation of autotransformers at regular intervals along the line, distance protection relays cannot be used with the aim of locating ground faults in 2 × 25 kV railway power supply systems. The reason is that the ratio between impedance and distance to the fault point is not linear in these electrification systems, unlike in 1 × 25 kV power systems. Therefore, the location of ground faults represents a complicated task in 2 × 25 kV railway power supply systems. Various methods have been used to localize the ground fault position in 2 × 25 kV systems. The method described here allows the location of a ground fault to be economically found in an accurate way in real time, using the modules of the circulating currents in different autotransformers when the ground fault occurs. This method first needs to know the subsection and the conductor (catenary or feeder) with the defect, then localizes the ground fault’s position.
A New Reconfigurable Bandpass Filter With Adaptive Resonators for Switchable Passband and In-Band Notch (2019)

A reconfigurable bandpass filter (BPF) with adaptive resonators is proposed for a switchable in-band notch. The adaptive resonator has two identical arms in parallel. When tuning the varactors in the two arms in different manner, the adaptive resonator results to different equivalent circuits. The prototype filter discussed here is an intrinsically switchable BPF. Comparing its even-and odd-mode resonances, it shows three different states, i.e. two bandpass and all-stop states. The adaptive resonators are integrated into this prototype filter. The obtained filtering responses are that each state of the prototype filter has a switchable in-band notch. Since both adaptive resonators and the prototype filter are reconfigurable with varactors, both the passband and in-band notch are tunable and switchable. An implemented experimental circuit has soundly verified the proposed technique.
ChemInform Abstract: η5‐CYCLOHEXADIENYLTRICARBONYLCHROMIUM(0) INTERMEDIATES IN THE REACTION OF CARBANIONS WITH η6‐ARENETRICARBONYLCHROMIUM(0) (1976)

Abstract Bei der Reaktion des Komplexes (I) mit Li‐Salzen von Carbanionen, die sich von Carbonsäuren mit pKa 25 ableiten, entstehen Zwischenprodukte wie die Komplexe (II), die NMR‐spektroskopisch charakterisiert werden.
Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin–proteasome system in response to intracellular calcium level (2011)

Cyclooxygenase (COX)-1 and hematopoietic prostaglandin (PG) D synthase (H-PGDS) proteins, which are both involved in the arachidonate cascade, were stable in human megakaryocytic MEG-01 cells. In contrast, once the intracellular calcium level was increased by treatment with a calcium ionophore, both protein levels rapidly decreased with a half-life of less than 30 and 120 min for COX-1 and H-PGDS, respectively. In the presence of a proteasome inhibitor, COX-1 and H-PGDS proteins accumulated within 10 and 30 min, respectively, and concurrently appeared as the high-molecular-mass ubiquitinated proteins within 30 and 60 min, respectively, after an increase in the intracellular calcium level. The ubiquitination of these proteins was also observed when ADP, instead of a calcium ionophore, was used as an inducer to elevate the intracellular calcium level. When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination. These results indicate that COX-1 and H-PGDS were rapidly ubiquitinated and degraded through the ubiquitin-proteasome system in response to the elevation of the intracellular calcium level.
Ring lasers and photodetectors on the hybrid III–V-on-Si platform (2016)

Silicon photonics, the art of achieving photonic functions on the Si-based platform, have been regarded as the most feasible solution for the growing request on data transmission, particularly in data center and high-performance computing applications. Higher bandwidth, lower cross talk, lower latency and lower power consumption are major advantages over the conventional metal interconnects. Consisting of a III-V epi bonded onto the Silicon-on-insulator (SOI) substrate, the III-V-on-Si platform has gained a lot of interest due to its practical solution to combine the desirable electrical and passive optical properties of Si and active optical properties of III-V. It is also compatible with Si metal-oxide-semiconductor (MOS) structure, which makes it promising for mass production. In this talk, we will review our recent work on the two critical components for an efficient hybrid transceiver, i.e., ring lasers with unprecedentedly low tuning power, and photodetectors with high speed, high responsivity, and low leakage current optimized at the same time.
Total synthesis of (+)-dihydromevinolin (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-dihydromevinolinScott J. Hecker and Clayton H. HeathcockCite this: J. Am. Chem. Soc. 1986, 108, 15, 4586–4594Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ja00275a053https://doi.org/10.1021/ja00275a053research-articleACS PublicationsRequest reuse permissionsArticle Views1310Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Quality Assessments of Persufflation and Cold Storage Preservation in Subnormothermic Isolated Porcine Kidneys (2017)

Alternative approaches for preservation methods are being studied to extend preservation time and minimize damage. This can enable the use of organs that are being discarded, especially donation after cardiac death (DCD) organs. Preventing complete energy depletion of the organ by providing gaseous oxygen using persufflation has the potential to prevent ischemic damage that occurs during and after preservation. For this study, kidneys from porcine donors were persufflated at hypothermic conditions while the other served as a static cold storage control, and subnormothermic liquid perfusion was performed for organ flushing and quality assessments. Porcine kidneys were procured post euthanasia to mimic a DCD model. After the isolated kidneys were exposed to 30 minutes of warm ischemia time (WIT), they were flushed with SPS-1 and preserved at 4°C for 24 hours in their respective conditions. After the preservation period, the organs were gradually rewarmed for 30 minutes to subnormothermic temperatures. Whole organ oxygen consumption rate (WOOCR) and glomerular filtration rate (GFR) were measured at 25°C to assess renal viability and function. Renal perfusate and biopsies were collected post preservation to evaluate renal damage using molecular analyses, biomarkers and histology. Results show significantly higher WOOCR of 281.8 nmol/(min*g) in the persufflated kidney compared to 225.5 nmol/(min*g) of the static cold storage control. The GFR was on average higher in the persufflated kidney at 17.7 ml/min and 3.67 ml/min in the cold storage group. Accumulated lactate levels overnight were significantly higher in the cold storage group at 3.17 nmol/L and 1.5 nmol/L in the persufflated group. Glutathione s-transferase levels were on average higher in the cold storage kidneys at 1.24 ug/ml with 1.01 ug/ml in the persufflated kidneys. Hematoxylin and eosin stained renal biopsies show that static cold storage kidneys on average exhibit more renal damage such as tubular epithelial necrosis, nephritis, tubulitis and multifocal, subcortical early infarct. Persufflated kidneys trend towards having more viable, oxygen consuming tissue and increased filtration activity and less indication of renal damage post preservation. Persufflation is a promising tool that has the potential to find a niche as a preservation method, especially since organs with a wide range of cold and warm ischemic damage are being used for transplantation.
Feasibility Study on Short Period Power Fluctuation Compensation Using Heat Pump Air Conditioning System (2012)

In order to compensate power fluctuations caused by loads and renewable energy sources, the concept of controllable load has been proposed. In this paper, the use of heat pump air conditioning system as a controllable load is focused. To analyze the feasibility of using the heat pump for power fluctuation compensation, basic characteristics of heat pump concerning its power consumption and processed heat are measured by experiments and reported in this paper. The COP characteristics show that the efficiency of the heat pump is not affected so much by power consumption as long as it is operated above a certain level of power consumption. The Bode diagram of sinusoidal reference signal test shows that the heat pump can compensate power fluctuation which is in a certain region in the frequency domain without giving a large effect on processed heat.
Optical multiplanar VLSI interconnects based on multiplexed waveguide holograms (1990)

Optical interconnects for very large scale integration systems based on planar waveguide holograms are analyzed. The combination of low loss waveguides and multiplexed waveguide holograms allows the construction of various compact planar architectures with high interconnect density and low insertion loss. The long interaction lengths possible in planar structures result in high angular and wavelength selectivity. Holographic grating couplers and multiplexed planar holograms for 1-to-3 interconnects and 1-to-3 multiple wavelength interconnects were fabricated.
Directed evolution of APEX2 for electron microscopy and proximity labeling (2014)

APEX is an engineered peroxidase that functions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics. Because limited sensitivity precludes applications requiring low APEX expression, we used yeast-display evolution to improve its catalytic efficiency. APEX2 is far more active in cells, enabling the use of electron microscopy to resolve the submitochondrial localization of calcium uptake regulatory protein MICU1. APEX2 also permits superior enrichment of endogenous mitochondrial and endoplasmic reticulum membrane proteins.
Aspects of luteovirus molecular biology in relation to the interaction between BYDV-PAV and the Yd2 resistance gene of barley / by John Paul Rathjen. (1995)

Chapter SixFult-length cDNA Clones of BYDY-RPV and BYDV'PAV Genomic RNAs for Agroinfection 6.1 Introduction 6.2 Materials and Methods ...... Generation of plant material infected with BYDV-RPV-Vic Purification of BYDV-RPV double-stranded RNA (dsRNA) PCR verification of BYDV-RPV dsRNA .............. RACE-PCR of the BYDV-RPV-Vic 5'and 3'genomic termini..... PCR amplification and cloning of cDNA segments covering the BYDV-RPV-Vic genome ............... Restriction analysis of PCR segments 1-4 ............ Overlapping cDNA segments of the BYDV-RPV-Vic genome 6.2.t 6.2.2 6.2.3 6.2.4 6.2.5 6.2.6 6.2.7 93 94 94 95 96 96 97 99 mutated to contain restriction sites in the overlaps......................
Correction (2005)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Heme-Binding Properties of HupD Functioning as a Substrate-Binding Protein in a Heme-Uptake ABC-Transporter System in Listeria monocytogenes (2014)

Abstract The HupDCG protein complex is a putative ABC-transporter for heme in the pathogenic Gram-positive bacterium Listeria monocytogenes, where HupD functions as a heme-binding protein. UV–vis absorption, EPR, and resonance Raman spectroscopy have revealed that HupD binds a heme with two histidine residues as the axial ligands. His105 and His259 are identified as the axial ligands by site-directed mutagenesis. HupD is the first example of a heme-binding protein having a bis-histidine coordination environment among the heme-binding proteins working in bacterial heme acquisition systems. While mutation of His259 to Ala resulted in a loss in the heme-binding ability of HupD, the H105A variant of HupD retained its heme-binding ability with lower heme-binding affinity compared with the wild type. These results suggest that His259 is an essential ligand for heme acquisition by HupD and that His105 might be responsible for regulation of the heme-binding affinity of HupD during the heme-transport process.
Novel form of the Michaelis–Menten equation that enables accurate estimation of (kcat/KM)*KI with just two rate measurements; utility in directed evolution (2017)

One of applications of directed evolution is to desensitize an enzyme to an inhibitor. kcat,1/KM and KI are three dimensions that when multiplied measure an enzyme's intrinsic capacity for catalysis in the presence of an inhibitor. The ideal values for the individual dimensions depend on substrate and inhibitor concentrations under the conditions of the application. When attempting to optimize those values by directed evolution, (kcat/KM)*KI can be an informative parameter for evaluating libraries of variants, but throughput is limited. We describe a manipulation of the Michaelis-Menten equation for competitive inhibition that isolates (kcat/KM)*KI on one side of the equation. If velocity is measured at constant enzyme and substrate concentrations with two different inhibitor concentrations (one of which can be 0), the data are sufficient to calculate (kcat/KM)*KI with just two rate measurements. The procedure is validated by correlating values obtained by the rapid method with those obtained by substrate saturation kinetics.
Effects of Phytic Acid, Divalent Cations, and Their Interactions on α‐Amylase Activity (1984)

ABSTRACT The effects of phytic acid and its interactions with divalent cations (Ca ++ and Mg ++ ) on α‐amylase activity were investigated in model systems. Amylase activity was influenced by both preincubation time with phytate as well as phytate concentration. At 6‐30 mM concentrations, Ca ++ and Mg ++ ions lowered the enzyme activity by 9‐34% and 24‐49%, respectively. When divalent cations were added simultaneously with phytate, a slight increase in enzyme activity with Ca ++ and lowered enzyme activity with Mg ++ were observed, as compared to when added independently. The enzyme activity was only moderately lowered when phytate was first preincubated with the divalent cations. Amylase inhibition by phytate was found to be of noncompetative type with an apparent inhibitor constant of 1.75 mM under the assay conditions.
Photonic crystal optical waveguides for on-chip Bose-Einstein condensates (2006)

We propose an on-chip optical waveguide for Bose-Einstein condensates based on the evanescent light fields created by surface states of a photonic crystal. It is shown that the modal properties of these surface states can be tailored to confine the condensate at distances from the chip surface significantly longer that those that can be reached by using conventional index-contrast guidance. We numerically demonstrate that by index-guiding the surface states through two parallel waveguides, the atomic cloud can be confined in a two-dimensional trap at about $1\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{m}$ above the structure using a power of $0.1\phantom{\rule{0.3em}{0ex}}\mathrm{mW}$.