gebhart/patrepeval huggingface dataset:
In vitro immunogenicity of inactivated Parapoxvirus ovis for lymphocytes from domestic animal species and humans (2000)

In immunology, the in vitro lymphocyte cell cultures stimulated with various polyclonal stimulators are used as a correlate for the assessment of in vivo cellular immune responsiveness to wast array of microbial/parasitic antigens, antibodies, cytokines, growth factors, nutrients, allogeneic/xenogeneic cells, and cytotoxic and therapeutic agents. The aim of the current study was to establish the capacity of freeze-dried preparation of inactivated Parapoxvirus ovis recommended by manufacturer (Bayer, Leverkusen, Germany) as a new formulation of an immune response modifier (Baypamun-N, BPMN) to induce proliferation of the immune cells from domestic animal species (rabbit, goat, swine, cow, horse, dog, and cat) and humans. Blood samples were collected into heparinized syringes and PBL were cultured with or without mitogens (PHA, ConA, PWM)/specific antigens (LPS, KLH, BPMN). All three concentrations of BPMN induced comparable proliferative responses of PBL from species tested to those induced by either mitogens or specific antigens. However, concentration of 20 ľl/ml of the preparation stimulated goat, rabbit, and cat PBL much better than any of stimulators applied. BPMN at this concentration stimulated PBL from horse, dog, pig, and man to respond with at least 50% of the average stimulation index (SI) value. At 10 ľl/ml BPMN highly stimulated caprine, equine, and human PBL (>100% of average SI value), and moderately (>50%) the cells from cat and pig. The lowest concentration of BPMN tested (5 ľl/ml) induced high response of bovine, porcine, and human immune cells (>100%), and good response of equine PBL (>95%). Generally, BPMN exhibited strongest stimulatory effect for porcine, caprine and human lymphocytes, moderately high effect for horse, cat, cow, and rabbit, and rather low effect for dog PBL.
Causes of efficiency roll-off in phosphorescent organic light emitting devices: Triplet-triplet annihilation versus triplet-polaron quenching (2010)

Delayed electroluminescence measurements are used to probe and differentiate between triplet-triplet-annihilation (TTA) and triplet-polaron-quenching (TPQ) processes and their correlation with efficiency roll-off in fac-tris(2-phenylpyridine) iridium-based phosphorescent organic light emitting devices. Investigations on devices employing 4,4′-bis(9-carbazolyl)-1,1′-biphenyl (CBP) and 4,4′,4″-tris(N-carbazolyl) triphenylamine, two widely used host materials, show that the efficiency roll-off is primarily due to TPQ processes. Guest-guest TTA, on the other hand, is found to play no major role, contrary to speculations, especially at low guest concentrations. Evidence of host-host TTA in certain cases, and its possible contribution to exciton quenching in the case of devices with CBP host, is also reported.
Functional neuroanatomy of spatial working memory in children. (2000)

Functional magnetic resonance imaging (fMRI) was used to examine spatial working memory in 8- to 11-year-old children tested under three conditions. In the visual condition, children were asked to examine the location of a dot on a screen. In the motor condition, children were instructed to push a button that corresponded to the location of a dot presented on a screen. In the memory condition, children were asked to remember the location of a dot presented 1 or 2 trials previously. Subtracting the activation of the motor condition from the memory condition revealed activity in the dorsal aspects of the prefrontal cortex and in the posterior parietal and anterior cingulate cortex. These findings were also obtained in the analysis of the memory minus visual conditions except that motor cortex activation was also observed. These findings parallel those reported in comparable studies of adults and suggest that fMRI may be a useful means of examining function-structure relations in developmental populations.
Relay backhaul subframe allocation in LTE-Advanced for TDD (2010)

Relay is a key technology in LTE-Advanced (LTE-A) for both FDD and TDD. A major aspect of relay technology is the backhaul subframe allocation. In this paper, we discuss backhaul subframe allocation for TDD-LTE and analyze all seven downlink-uplink configurations for completeness. The discussion is
Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (1994)

TFIIA is thought to play an important role in transcriptional regulation in higher eukaryotes, but its precise function is unclear. A human cDNA encoding a protein with 45% identity to the small subunit of yeast TFIIA has been isolated. TFIIA activity could be reconstituted by the mixing of recombinant large (alpha beta) and small (gamma) subunits. TFIIA-depleted HeLa nuclear extracts were used to demonstrate that TFIIA is essential for basal and activated transcription by several distinct classes of activators. Recombinant TFIIA functioned in transcriptional activation whether expressed as a dimer (alpha beta+gamma) or as a trimer (alpha+beta+gamma), which closely resembles the native form. Yeast TFIIA also functioned in transcriptional activation, and the human gamma subunit was functionally interchangeable with TOA2, its yeast homolog. Recombinant TFIIA mediated the stimulation of TFIID binding to the TATA region and downstream promoter sequences by the Zta transcriptional activator. Significantly, we found that TFIIA bound directly to Zta in an activation domain-dependent manner. One consequence of the TFIIA-mediated interaction between Zta and TFIID was the formation of a promoter-bound complex resistant to TATA oligonucleotide competition. These results demonstrate that TFIIA is an evolutionarily conserved general factor critical for activator-regulated transcription.
Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation. (1997)

These results suggest that additional therapeutic benefit may be obtained from FUra regimens by (1) appropriate schedule-dependent modulation, (2) the sequential or alternating use of cycles of bolus followed by cycles of CI FUra appropriately modulated, or (3) hybrid regimens, ie, those that contain both pulse and CI schedules.
Joint capacity planning and operational management for sustainable data centers and demand response (2016)

Reducing costs plays a crucial role in building and operating data centers. Internet service providers such as Facebook and Google spend billions of dollars on capacity expansion and operations of their global data centers. Traditionally, capacity planning for data centers is done separately from operational management, which incurs inefficiency. In fact, operational management has significant impacts on capacity planning. Motivated by this gap, we propose a framework that jointly optimizes both capacity planning and operational management for sustainable data centers and data centers participating in demand response programs. Numerical results based on real-world cases highlight that the proposed framework remarkably reduces up to 50% of total expenditures and 75% of greenhouse gas emissions compared to conventional methods. Additionally, our results show that participations in various demand response programs result in vastly different capacity planning decisions and lead to emission reductions of up to 60%.
Supplementary Table 3 from Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis (2023)

&lt;p&gt;RNA sequencing result&lt;/p&gt;
Abstract 249: Combination of ONC201 with radiation exhibits synergistic efficacy in high grade gliomas and other advanced cancers (2019)

Background: Radiation is widely administered in many treatment settings for solid tumors. ONC201 is the first small molecule DRD2 antagonist for oncology that is being investigated in advanced cancer clinical trials as a single agent. ONC201 has exhibited preclinical and clinical anti-tumor activity in high grade gliomas and its immunostimulatory activity involving natural killer (NK) cells has been recently reported. Given that ONC201 exhibits broad synergy with anti-cancer drugs, excellent safety, and single activity in tumor types where radiation is used routinely, we evaluated the combination of ONC201 with radiation.Methods: Cell viability was evaluated in human and/or mouse breast, prostate and high grade glioma cell lines in response to ONC201 (1 - 10uM), radiation (2- 10 Gy), or the combination. Incubation times ranged from 24 to 96 hours and the sequence of the two agents in combination was varied.Results: Cell viability assays for ONC201 in combination with radiation in breast or prostate cancer cell lines revealed a cytotoxic response to the combination that was superior to either single agent. Western blot analysis of PC3 cells showed a synergistic induction of CHOP and ATF6 that are components of the integrated stress response. In glioblastoma or diffuse intrinsic pontine glioma (DIPG) cell lines, combination indices computed from cell viability experiments indicated modest synergy (~0.7 CI) for the combination ranging between 1-5 µM ONC201 and 2-10 Gy. In MDA-MB-468 breast cancer cells, Western blot analysis demonstrated a striking induction of PARP cleavage, a marker of caspase-mediated apoptosis, with 2 µM ONC201 in combination with 2 Gy radiation, whereas either single agent produced minimal PARP cleavage. In 4T1 murine triple-negative breast cancer subcutaneous tumors, the combination of oral ONC201 and radiation produced antitumor effects at subtherapeutic doses that required CD4+ T cells and NK cells.Conclusions: ONC201 combined with radiation produced additive or synergistic anti-cancer effects in high grade glioma, breast and prostate cancer in vitro and increased anti-tumor efficacy in an in vivo model of breast cancer that involved immune cells.Citation Format: Rohinton S. Tarapore, Sachin Jhawar, Mark Stein, Andrew Zloza, Sabine Mueller, Jie Zhang, Francesca Amoroso, Ian Mills, Wolfgang Oster, Joshua Allen. Combination of ONC201 with radiation exhibits synergistic efficacy in high grade gliomas and other advanced cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 249.
Os Acromiale as a Cause for Shoulder Pain in a Competitive Swimmer: A Case Report (2009)

Shoulder pain is the most common orthopaedic complaint of competitive swimmers. Epidemiological studies have reported the incidence and recurrence rates of shoulder pain to be as high as 80% among top US competitors.16 Although the precise origin of pain may be elusive, the term “swimmer’s shoulder” has been used to describe the inflammation resulting from dynamic impingement of the rotator cuff and coracoacromial arch. Long training seasons, repetitive overhead arm motion, overuse fatigue, increased glenohumeral laxity, and poor swimming technique may all contribute to the shoulder pain that frequently occurs in this unique group of athletes.2,10,11,15,17

In this report, we present a female Division I collegiate swimmer with shoulder pain secondary to a symptomatic os acromiale. This patient’s presentation serves to provide clinicians a sentinel reminder to consider all potential causes of shoulder pain in competitive athletes, particularly in the setting of a more common, confounding diagnosis.
α‐Interferon treatment for idiopathic hypereosinophilic syndrome (1994)

Idiopathic hypereosinophilic syndrome (HES) is a poorly understood disorder characterized by a markedly elevated peripheral blood eosinophil count in the absence of known associated causes of hypereosinophilia. Idiopathic hypereosinophilic syndrome is associated with eosinophil-induced organ damage, including endomyocardial and pulmonary fibrosis, stroke, and gastrointestinal disease. Treatment of idiopathic HES is centered on the reduction of peripheral circulating eosinophils in an effort to diminish tissue infiltration and destruction. Multiple cytotoxic agents have been tried, with variable results. Prednisone and hydroxyurea have remained the therapies of choice in long term treatment of idiopathic HES. We report here the successful 2 year treatment of aggressive idiopathic HES, refractory to hydroxyurea and prednisone, with alpha-interferon.
R)Evolutionary Bootstrapping of a Global PKI for Securing BGP. (2006)

Most secure routing proposals require the existence of a global public-key infrastructure (PKI) to bind a public/private key-pair to a prefix, in order to authenticate route originations of that prefix. A major difficulty in secure routing deployment is the mutual dependency between the routing protocol and the establishment of a globally trusted PKI for prefixes and ASes: cryptographic mechanisms used to authenticate BGP Update messages require a PKI, but without a secure routing infrastructure in place, Internet registries and ISPs have little motivation to invest in the development and deployment of this PKI. This paper proposes a radically different mechanism to resolve this dilemma: an evolutionary Grassroots-PKI that bootstraps by letting any routing entity announce self-signed certificates to claim their address space. Despite the simple optimistic security of this initial stage, we demonstrate how a Grassroots-PKI provides ASes with strong incentives to evolve the infrastructure into a full top-down hierarchical PKI, as proposed in secure routing protocols like S-BGP. Central to the Grassroots-PKI concept is an attack recovery mechanism that by its very nature moves the system closer to a global PKI. This admittedly controversial proposal offers a rapid and incentivecompatible approach to achieving a global routing PKI.
Investigation on structure and properties of arc-evaporated HfAlN hard coatings (2010)

HfAlN hard coatings were synthesized by cathodic arc evaporation from Hf0.75Al0.25 targets at different bias voltages and N2 pressures. Structural investigations by x-ray diffraction (XRD) revealed the formation of a face-centered cubic (fcc) structure with a change in the preferred orientation depending on the energetic growth conditions. This change in the crystal structure did not significantly influence the mechanical properties, e.g., hardness, where values ranging from 24 to 26 GPa were measured. The obtained fcc phase is stable up to 1000 °C as no significant changes in the crystal structure could be observed after annealing in vacuum. Similar experiments in ambient air and subsequent analysis of the coatings by XRD and Raman spectroscopy revealed an onset temperature for oxidation in the range of 700–800 °C and the formation of monoclinic HfO2 as the dominating oxide phase. Ball-on-disk tests at different temperatures were performed in order to evaluate the tribological properties. The coefficient of friction ranged from 0.8 to 1.2 depending on the testing temperature while the best wear performance was obtained in the temperature range of 300–500 °C.
Model-based biological Raman spectral imaging (2002)

Raman spectral imaging is a powerful tool for determining chemical information in a biological specimen. The challenge is to condense the large amount of spectral information into an easily visualized form with high information content. Researchers have applied a range of techniques, from peak-height ratios to sophisticated models, to produce interpretable Raman images. The purpose of this article is to review some of the more common imaging approaches, in particular principal components analysis, multivariate curve resolution, and Euclidean distance, as well as to present a new technique, morphological modeling. How to best extract meaningful chemical information using each imaging approach will be discussed and examples of images produced with each will be shown.
Pulsed metal-organic chemical vapor deposition of high-quality AlN/GaN superlattices for near-infrared intersubband transitions (2009)

A pulsed metal-organic chemical vapor deposition technique is developed for the growth of high-quality AlN/GaN superlattices (SLs) with intersubband (ISB) transitions at optical communications wavelengths. Tunability of the AlN and GaN layers is demonstrated. Indium is shown to improve SL surface and structural quality. Capping thickness is shown to be crucial for ISB transition characteristics. Effects of barrier- and well-doping on the ISB absorption are reported.
Advanced dextran based nanogels for fightingStaphylococcus aureusinfections by sustained zinc release (2014)

The growth in numbers and severity of hospital acquired infections has increased the need to target bacteria locally and specifically. Consequently, smart drug-delivery systems are being developed for local bactericidal action. The approach takes the concept of nanogels in drug delivery of small molecules to the next level by enclosing them in a shell. Versatile polysaccharide nanogels were loaded with zinc ions as antibacterial agents in a miniemulsion process, in order to target methicillin resistant strains of Staphylococcus aureus (MRSA). The encapsulation of drugs in nanogels is limited by the crosslinking density of the gel and the size of the drug. The characterization of the nanogels with inductively coupled plasma optical emission spectroscopy (ICP-OES) revealed that zinc ions cannot be retained within without an additional 'shell' layer. The nanogels were surrounded by a dextran-polyurethane shell, which can retain substances by reduction of water penetration. A delayed zinc release compared to the nanogels was confirmed by ICP-OES. Bacterial tests revealed an antibacterial effect of the shell enhanced nanogels against S. aureus. The studied nanogel system shows potential in locally addressing bacterial infections. The platform is extremely versatile and can be tailored to application as dextran and Zn(NO<sub>3</sub>)<sub>2</sub> can be replaced by other polysaccharides (e.g. hyaluronic acid) and antibacterial agents, respectively.
ChemInform Abstract: Fullerene Nanotubes, Fibers, and Wires (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highly Interpenetrated Supramolecular Networks Supported by N⋅⋅⋅I Halogen Bonding (2007)

Halogen bonding (XB) has been used to assemble tetrakis(4-pyridyl)pentaerythritol (tetradentate XB acceptor) with different alpha,omega-diiodoperfluoroalkanes (bidentate XB donors) or tetrakis(4-iodotetrafluorophenyl)pentaerythritol (tetradentate XB donor). The remarkable linearity of the XB formed, the rodlike character of alpha,omega-diiodoperfluoroalkanes and the mutual complementarities of pentaerythritol partners, translate the three-dimensional character of the XB acceptor into open primary networks, which interpenetrate to avoid the presence of voids and to ensure segregation of the modules. Two-dimensional (2D) square 4(4) layers (sql) with fourfold and fivefold interpenetration, as well as an eightfold diamondoid network (dia) of class Ia and a remarkable tenfold dia network of class IIIa, have been obtained.
Analytic Method for Estimating Aircraft Fix Displacement from Gyroscope's Allan-Deviation Parameters (2022)

The noise and drift requirements for a navigation-grade gyroscope are widely known, yet there is no simple analytic model of how the noise and drift of a gyroscope influence the fix displacement error (FDE) of an inertial navigation system (INS). This work derives simple analytical expressions for the cross-track and along-track errors of an aircraft whose INS consists solely of a three-axis gyroscope system with perfect knowledge of the vertical direction. The error signal of each gyroscope is Gaussian white noise and drift modeled as a first-order Markov random walk. These expressions provide a straightforward mean of calculating the FDE of an aircraft as a function of the flight duration, velocity, noise amplitude, drift amplitude, and drift's time constant. These expressions are validated with Monte-Carlo simulations of long flights. This model quantifies the noise-versus-drift trade-off for a gyroscope in an inertial navigation system. It can save time when estimating the noise and drift that a gyroscope must exhibit to satisfy a given position-error requirement, or vice versa. They are used in particular to confirm the values, often cited without demonstration, of the noise and drift required to meet the maximum position error of an aircraft imposed by the Federal Aviation Administration's required navigation performance 10 specification. Finally, it demonstrates that using the minimum in the measured Allan deviation of a gyroscope as a metric of the drift is incorrect, because it fails to capture the drift's time constant. The proper metric is the maximum in the Allan deviation.
Integration of Bridging-Structural SWNTs on Flexible PDMS Sheet by Stamping Transfer (2009)

This paper describes an integration method of bridging-structural single-walled carbon nanotubes (SWNTs) onto the flexible PDMS sheet by stamping transfer. Silicon microstructures and the SWNTs which directly synthesized between the gaps of the microstructures were lifted off by PDMS stamp sheets with high yield (97.8%) and accuracy (position error <100 nm). From the SEM observation of our transferred structures, we confirmed that our method could transfer the bridging-structural SWNTs on to the flexible materials without any damage to the SWNTs' bridging.
Thermal Emission from Multi-mode Optical Antennas on an Epsilon-Near-Zero Substrate (2020)

Far-field thermal emission is measured for multi-mode optical antennas fabricated on an epsilon-near-zero substrate. The evolution of the emission pattern for the Berreman and first and second antenna modes versus antenna length is presented.
Color Variation Improvement by Introducing Double Emission Layers in WPLEDs (2007)

We have fabricated white polymeric light-emitting devices (WPLEDs) from polyfluorene-based (PFO) blue and MEH-PPV polymer blending systems. A device structure of ITO/PEDOT:PSS/Blending polymer/Blue polymer/LiF/Al was employed. This double emissive structure results in the significant improvement of white color shift phenomenon. A current efficiency of 4.67 cd/A (3,900 cd/m2, 6.4 V) and a brightness value of 17,600 cd/m2 at 9.4 V with (0.34, 0.35) CIE coordinates at 5 V and (0.29, 0.29) at 9 V were obtained.
Buying a Packaged Farm Building (1993)

More than half the farm buildings constructed in Missouri today are selected from the wide variety of 'pre-engineered' structures available from commercial manufacturers or large contracting firms. These buildings, commonly referred to as "package buildings," have been designed to reduce construction costs through standardization. This guide outlines some of the options and decisions you will have to make when shopping for and purchasing a package-type farm building.