gebhart/patrepeval huggingface dataset:
Multi-objective stable matching with ties (2017)

Stable Matching (SM) has received a lot of attention from researchers due to its useful applications in practice. Gale and Shapley were the first to propose a polynomial-time algorithm to find an SM solution, for matching with strict preferences. However, their algorithm often produces extreme stable solutions, favouring either men or women. In practice, the real-life problems have multiple objectives (equitable and welfare) and preferences are not strict, consequently ties occur. With the inclusion of ties and objectives, the problem becomes NP-hard. A few researchers proposed local search and evolutionary algorithms to solve multi-objective SM problem with ties, but these methods were not scalable. In this paper, we propose an efficient Goal Programming and Repair Heuristics based approach to solve this problem. On comparison with other related works, our approach shows significant improvement in respective objectives (equity and welfare). This approach with slight modification can be proved useful for solving other hard variants of the SM problem.
Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis (2017)

This work describes the first example of using chiral catalysts to control site-selectivity for the glycosylations of complex polyols such as 6-deoxyerythronolide B and oleandomycin-derived macrolactones. The regiodivergent introduction of sugars at the C3, C5, and C11 positions of macrolactones was achieved by selecting appropriate chiral acids as catalysts or through introduction of stoichiometric boronic acid-based additives. BINOL-based chiral phosphoric acids (CPAs) were used to catalyze highly selective glycosylations at the C5 positions of macrolactones (up to 99:1 rr), whereas the use of SPINOL-based CPAs resulted in selectivity switch and glycosylation of the C3 alcohol (up to 91:9 rr). Additionally, the C11 position of macrolactones was selectively functionalized through traceless protection of the C3/C5 diol with boronic acids prior to glycosylation. Investigation of the reaction mechanism for the CPA-controlled glycosylations revealed the involvement of covalently linked anomeric phosphates rather than oxocarbenium ion pairs as the reactive intermediates.
Risico op verspreiding van Xanthomonas tijdens CATT aardbeiplanten (2015)

Risico tijdens CATT op overdracht van Xanthomonas zeer gering De belangrijkste conclusie uit het onderzoek naar de overdracht van Xanthomonas van plant naar plant tijdens CATT is dat dit risico uitermate klein is. Bij latent geinfecteerd plantmateriaal werden geen aanwijzingen gevonden voor de verspreiding van Xanthomonas tijdens CATT. Dit suggereert dat in een partij zonder symptomatische planten het risico op verspreiding van Xanthomonas nagenoeg afwezig is. Werd zwaar besmet symptomatisch plantmateriaal blootgesteld aan CATT dan werd af en toe met de Bio-TaqMan een aanwijzing voor besmetting van doelplanten gevonden. Dit leidde overigens in geen van deze gevallen tot het daadwerkelijk isoleren van de Xanthomonas bacterie. Ook werd geen symptoomontwikkeling in de doelplanten waargenomen, nadat deze waren uitgeplant en nageteeld. Dit geeft aan dat hoewel verspreiding tijdens CATT niet geheel uit te sluiten is, het risico van infectie van Xanthomonas-vrije planten zeer klein is.
100 GHz-32 ch athermal AWG with extremely low temperature dependency of center wavelength (2004)

New athermal AWG with 100 GHz-32 ch has been developed. This novel athermal AWG exhibits excellent property in temperature dependency of center wavelength less than /spl plusmn/0.01 nm under the temperature range 0 to 70/spl deg/C.
Listen and whisper: security mechanisms for BGP (2004)

BGP, the current inter-domain routing protocol, assumes that the routing information propagated by authenticated routers is correct. This assumption renders the current infrastructure vulnerable to both accidental misconfigurations and deliberate attacks. To reduce this vulnerability, we present a combination of two mechanisms: Listen and Whisper. Listen passively probes the data plane and checks whether the underlying routes to different destinations work. Whisper uses cryptographic functions along with routing redundancy to detect bogus route advertisements in the control plane. These mechanisms are easily deployable, and do not rely on either a public key infrastructure or a central authority like ICANN. The combination of Listen and Whisper eliminates a large number of problems due to router misconfigurations, and restricts (though not eliminates) the damage that deliberate attackers can cause. Moreover, these mechanisms can detect and contain isolated adversaries that propagate even a few invalid route announcements. Colluding adversaries pose a more stringent challenge, and we propose simple changes to the BGP policy mechanism to limit the damage colluding adversaries can cause. We demonstrate the utility of Listen and Whisper through real-world deployment, measurements and empirical analysis. For example, a randomly placed isolated adversary, in the worst case can affect reachability to only 10% of the nodes.
The Biological Effects of Combining Metals in a Posterior Spinal Implant:In VivoModel Development Report of the First Two Cases (2014)

Study Design . Combinations of metal implants (stainless steel (SS), titanium (Ti), and cobalt chrome (CC)) were placed in porcine spines. After 12 months, tissue response and implant corrosion were compared between mixed and single metal junctions. Objective. Model development and an attempt to determine any detriment of combining different metals in posterior spinal instrumentation. Methods . Yucatan mini-pigs underwent instrumentation over five unfused lumbar levels. A SS rod and a Ti rod were secured with Ti and SS pedicle screws, SS and Ti crosslinks, SS and CC sublaminar wires, and Ti sublaminar cable. The resulting 4 SS/SS, 3 Ti/Ti, and 11 connections between dissimilar metals per animal were studied after 12 months using radiographs, gross observation, and histology (foreign body reaction (FBR), metal particle count, and inflammation analyzed). Results . Two animals had constructs in place for 12 months with no complications. Histology of tissue over SS/SS connections demonstrated 11.1 ± 7.6 FBR cells, 2.1 ± 1.7 metal particles, and moderate to extensive inflammation. Ti/Ti tissue showed 6.3 ± 3.8 FBR cells, 5.2 ± 6.7 particles, and no to extensive inflammation (83% extensive). Tissue over mixed components had 14.1 ± 12.6 FBR cells and 13.4 ± 27.8 particles. Samples surrounding wires/cables versus other combinations demonstrated FBR (12.4 ± 13.5 versus 12.0 ± 9.6 cells, P = 0.96), particles (19.8 ± 32.6 versus 4.3 ± 12.7, P = 0.24), and inflammation (50% versus 75% extensive, P = 0.12). Conclusions . A nonfusion model was developed to study corrosion and analyze biological responses. Although no statistical differences were found in overlying tissue response to single versus mixed metal combinations, galvanic corrosion between differing metals is not ruled out. This pilot study supports further investigation to answer concerns when mixing metals in spinal constructs.
Spatially Segregated SNARE Protein Interactions in Living Fungal Cells (2007)

The machinery for trafficking proteins through the secretory pathway is well conserved in eukaryotes, from fungi to mammals. We describe the isolation of the snc1, sso1, and sso2 genes encoding exocytic SNARE proteins from the filamentous fungus Trichoderma reesei. The localization and interactions of the T. reesei SNARE proteins were studied with advanced fluorescence imaging methods. The SSOI and SNCI proteins co-localized in sterol-independent clusters on the plasma membrane in subapical but not apical hyphal regions. The vesicle SNARE SNCI also localized to the apical vesicle cluster within the Spitzenkörper of the growing hyphal tips. Using fluorescence lifetime imaging microscopy and Foerster resonance energy transfer analysis, we quantified the interactions between these proteins with high spatial resolution in living cells. Our data showed that the site of ternary SNARE complex formation between SNCI and SSOI or SSOII, respectively, is spatially segregated. SNARE complex formation could be detected between SNCI and SSOI in subapical hyphal compartments along the plasma membrane, but surprisingly, not in growing hyphal tips, previously thought to be the main site of exocytosis. In contrast, SNCI.SSOII complexes were found exclusively in growing apical hyphal compartments. These findings demonstrate spatially distinct sites of plasma membrane SNARE complex formation in fungi and the existence of multiple exocytic SNAREs, which are functionally and spatially segregated. This is the first demonstration of spatially regulated SNARE interactions within the same membrane.
Fundamental mode operation of a ribbon fiber laser by way of volume Bragg gratings (2014)

Selection of the fundamental mode of an active large mode area "ribbon" fiber laser with core dimensions of 107.8 μm by 8.3 μm was produced by a transmitting Bragg grating (TBG) in a free-space resonator. The multimode performance of the original laser was characterized to have an M2 of 11.3 with an absorbed power slope efficiency of 76%. With the TBG aligned to provide maximum diffraction efficiency for the fundamental mode, the M2 improved to 1.45 at an absorbed power slope efficiency of 54% and enhanced the brightness by 5.1 times.
Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy (2006)

Acid-base properties of the natural polyamine wasp toxin PhTX-433 (1) and seven synthetic analogues [PhTX-343 (2), PhTX-334 (3), PhTX-443 (4), PhTX-434 (5), PhTX-344 (6), PhTX-444 (7), and PhTX-333 (8)], each having four protolytic sites, were characterized by 13C NMR spectroscopy. Nonlinear, multiparameter, simultaneous fit of all chemical shift data obtained from the NMR titration curves yielded macroscopic pKa values as well as intrinsic chemical shift data of all differently protonated macrospecies. Analyses of the chemical shift data demonstrated strong interactions between all four sites and provided information about complex relationships between chemical shift values and protonation state. Deprotonation of fully protonated forms starts at the central amino group of the polyamine moiety, and the extent of this trend depends on the distance to the flanking, protonated amino groups. The pKa1 values of 1-8 are in the range 8.2-9.4. Hence, some of the toxins are incompletely protonated at the pH and ionic strength conditions used for assessment of their interactions with ionotropic glutamate and nicotinic acetylcholine receptors, and the degree of protonation is expected to have pharmacological importance in the ion-channel binding event.
Oxygen Exchange at the Internal Surface of AmorphousSiO2Studied by Photoluminescence of Isotopically Labeled Oxygen Molecules (2009)

The exchange between lattice and interstitial oxygen species in an oxide was studied by the 16O-18O isotope shift of the a1Deltag(v=0)-->X3Sigmag-(v=1) infrared photoluminescence band of the oxygen molecules (O2) incorporated into the interstitial voids of amorphous SiO2 (a-SiO2) by thermal annealing in 18O2 gas. A large site to site variation of the oxygen exchange rate, originating from structural disorder of a-SiO2, is found. The average exchange rate has an activation energy of approximately 2 eV, which is much larger than that for the diffusion of interstitial O2 (approximately 0.8-1.2 eV). The average exchange-free diffusion length of interstitial O2 exceeds approximately 1 microm below 900 degrees C, providing definite evidence that oxygen diffuses as interstitial molecules in a-SiO2.
Mechanical Unloading by Fulminant Myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA, and PROPELLA Concepts (2018)

Mechanical circulatory support (MCS) is often required to stabilize patients with acute fulminant myocarditis with cardiogenic shock. This review gives an overview of the successful use of left-sided Impella in the setting of fulminant myocarditis and cardiogenic shock as the sole means of MCS as well as in combination with right ventricular (RV) support devices including extracorporeal life support (ECLS) (ECMELLA) or an Impella RP (BI-PELLA). It further provides evidence from endomyocardial biopsies that in addition to giving adequate support, LV unloading by Impella exhibits disease-modifying effects important for myocardial recovery (i.e., bridge-to-recovery) achieved by this newly termed "prolonged Impella" (PROPELLA) concept in which LV-IMPELLA 5.0, implanted via an axillary approach, provides support in awake, mobilized patients for several weeks. Finally, this review addresses the question of how to define the appropriate time point for weaning strategies and for changing or discontinuing unloading in fulminant myocarditis.
Filamentary and Homogeneous Modes of Dielectric Barrier Discharge (DBD) in Air: Investigation through Plasma Characterization and Simulation of Surface Irradiation (2010)

Abstract The reported dielectric barrier discharge (DBD) source comprises of a ceramic‐covered copper electrode, and plasma can be ignited in ambient air with grounded ‘opposite’ electrodes or with objects of high capacitance (e.g., human body), when breakdown conditions are satisfied. Filamentary plasma mode is observed when the same source is operated using grounded opposite electrodes like aluminium plate and phosphate buffered saline solution, and a homogeneous plasma mode when operated on glass. When the source is applied on human body, both homogeneous and filamentary discharges occur simultaneously which cannot be resolved into two separate discharges. Here, we report the characterization of filamentary and homogeneous modes of DBD plasma source using the above mentioned grounded electrodes, by applying optical emission spectroscopy, microphotography and numerical simulation. Averaged plasma parameters like electron velocity distribution function and electron density are determined. Fluxes of nitric oxide, ozone and photons reaching the treated surface are simulated. These fluxes obtained in different discharge modes namely, single‐filamentary discharge (discharge ignited in same position), stochastical filamentary discharge and homogeneous discharge are compared to identify their applications in human skin treatment. It is concluded that the fluxes of photons and chemically‐active particles in the single filamentary mode are the highest but the treated surface area is very small. For treating larger area, the homogeneous DBD is more effective than stochastical filamentary discharge. magnified image
Modulation of Tumor-Infiltrating Lymphocytes Derived from Human Renal Cell Carcinoma by Interleukin-4 (1992)

Current methods of expanding tumor-infiltrating lymphocytes (TILs) from renal cell carcinoma bulk cultures result in a heterogeneous population of cells with low tumor-killing specificity. To improve the yield of cells with higher autologous and lower nonspecific cytotoxicity, interleukin-4 (IL-4) was added to high (1,000 U/ml)- and low (20 U/ml)-dose IL-2 and compared to cultures grown without IL-4 for proliferation, phenotype, and cytotoxicity against targets including autologous and allogeneic tumors. When compared to culture in IL-2 alone, the addition of IL-4 improved overall expansion in both high-dose (mean fold expansion of 2,061 vs. 1,087) and low-dose (mean fold expansion of 1,904 vs. 262) IL-2. Enhancement of TIL proliferation was dependent on the timing of IL-4 addition to the culture; augmented growth occurred only when IL-4 was added with or following activation by IL-2. The phenotype consisted primarily of CD3+/CD4+ lymphocytes with a reciprocal reduction in CD56+/CD16+ cells. Finally, there was a significant reduction in nonspecific cytotoxicity against K-562, M-14, and allogeneic tumor targets, but no significant change against autologous tumor. We conclude that IL-4 has an important regulatory effect on the expansion of renal cell carcinoma TILs in IL-2 by the promoting growth of CD3+/CD4+ lymphocytes and inhibiting the growth and nonspecific cytotoxicity associated with LAK-like CD16+/CD56+ cells. These findings may be beneficial in extracting more potent effector cells from bulk TIL culture for use in clinical trials.
Relative costs and benefits of implementing desiccant bead drying/hermetic storage and alternative drying and storage technologies for vegetable seeds in Kenya and Tanzania (2020)

This paper assesses the relative costs and benefits of desiccant beads drying/hermetic storage and alternative drying and storage technologies. The study was conducted in Kenya and Tanzania in areas producing and trading vegetable seeds using a sample size of 280 respondents. The study revealed that costs of desiccant bead drying/hermetic storage are relatively higher for smaller quantities of seeds compared to alternative technologies. No storage losses are incurred with hermetic storage but high losses occur for ordinary storage. Using a combination of desiccant bead drying and hermetic storage is relatively more economical compared to using desiccant drying alone. There are economies of scale in the use of desiccant bead drying/hermetic storage compared to alternative technologies. Quantities of seeds that generate equal net benefits for both desiccant bead/hermetic storage and sun drying/ordinary storage range from 120 to 900 kg for African night shade and Amaranthus, and 300 to 1500 kg for beans. Efficiency in production and marketing is likely to encourage the use of desiccant bead drying/hermetic storage, which would be beneficial to farmers. Taking 15 kg of African night shade seeds and 18 kg of Amaranthus seeds, price premiums that would be necessary for farmers to receive for there to be an economic incentive for them to use the beads are approximately 35% for Amaranthus and 20% for the African night shade. Given efficiency of desiccant bead drying/hermetic storage it is likely to offer more benefits to farmers and traders compared to sun drying and other storage technologies. Key words: Drying, storage, desiccant beads, moisture content, costs and benefits. &nbsp;
Sparsity in Topic Models (2014)

This is a draft containing only sra chapter.tex and an abbreviated front matter. Please check that the formatting and small changes have been performed correctly. Please verify the affiliation. Please use this version for sending us future modifications. The MIT Press
ChemInform Abstract: All Eight Stereoisomeric D‐Glyconic‐δ‐lactams: Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Spin profiles reconstruction in low-PMD fibers by long range polarization-sensitive optical coherence tomography (2006)

Polarization-sensitive optical coherence tomography is proved an efficient nondestructive technique for spin profile reconstruction along spun fiber coils, allowing birefringence parameter spatial evolution to be recovered from Stokes analysis of backscattered light, with sub-centimetric resolution.
Deposition of diamond films at low pressures and their characterization by positron annihilation, Raman, scanning electron microscopy, and x-ray photoelectron spectroscopy (1990)

We have deposited diamond films with micron-size crystals on Si〈111〉 using low-pressure hot-filament-assisted chemical vapor deposition. These films have been characterized by positron annihilation, Raman spectroscopy, scanning electron microscopy, and x-ray photoelectron spectroscopy. In addition to the results for the electronic structure and morphology, we also present new results for the lattice defects present in these films.
Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells (2019)

Frequent mutation of genes in the PI3K/AKT/mTOR signaling pathway in human cancers has stimulated large investments in therapeutic drugs but clinical successes have been rare. As a result, many cancers with high PI3K pathway activity such as triple-negative breast cancer (TNBC) are still treated primarily with conventional chemotherapy. By systematically analyzing responses of TNBC cells to a diverse collection of PI3K pathway inhibitors, we find that one drug, Torin2, is unusually effective because it inhibits both mTOR and PI3K-like kinases (PIKKs). In contrast to mTOR-selective inhibitors, Torin2 exploits dependencies on several kinases for progression of S-phase and for cell cycle checkpoints, thereby causing accumulation of single-stranded DNA and death by replication catastrophe or mitotic failure. Thus, Torin2 and its analogs represent a mechanistically distinct class of PI3K pathway inhibitors that are uniquely cytotoxic to TNBC cells. This insight could be translated therapeutically by further developing Torin2 analogs or combinations of existing mTOR and PIKK inhibitors.
Average performance and variability (2000)

‘The continued fantasy that there is, will be, or should be a single computer architecture for all problem spaces (or a single yardstick to measure such things) continues to fascinate me. Why should computing be different from everything else in Human experience?’Keith Bierman, in comp.benchmarks
Synthesis and Physical Investigation of Donor–Donor and Acceptor–Acceptor End-Functionalized Monodisperse Poly(triacetylene) Oligomers (2000)

Two series of monodisperse, terminally donor-donor [D-D, D=4-(dimethylamino)phenyl] and acceptor-acceptor [A-A, A=4-nitrophenyl] functionalized poly(triacetylene) (PTA) oligomers ranging from monomer to hexamer were synthesized by oxidative Hay oligomerization under end-capping conditions. The corresponding D-D and A-A end-substituted polymers with an average degree of polymerization (DP) of n approximately 18 and n approximately 12, respectively, were also prepared and served as reference points for the corresponding infinitely long polymers. These terminally functionalized PTA oligomers and polymers are yellow- to orange-colored compounds, displaying excellent solubility in aprotic solvents with melting points above 200 degrees C for the hexamers. For the 4-(dimethylamino)phenyl substituted compounds, a consistent first oxidation potential around +0.42 V versus Fc/Fc+ (ferrocene/ferricinium) was observed, whereas the 4-nitrophenyl functionalized systems underwent a reversible reductive two-electron transfer around -1.40V versus Fc/Fc+. The nature of the end-groups has a dramatic influence on the electronic absorption spectra. Saturation of the linear optical properties in the D-D series occurs at significantly shorter chain-length [effective conjugation length (ECL) of n approximately 4 monomer units] than in the A-A substituted or the previously reported Me3Si- and Et3Si-end-capped PTA oligomer series (ECL: n approximately 10 monomer units). Similar observations with respect to the ECL were made by measurement of the Raman-active v(C triple bound C) stretches. Third-harmonic generation (THG) and degenerate four-wave mixing (DFWM) experiments showed that shorter oligomers of terminally D-D or A-A functionalized PTAs display higher second hyperpolarizabilities gamma than the corresponding R3Si-end-capped series (R=alkyl). Moreover, they disclose a distinct peak of the nonlinearity per monomer unit at intermediate backbone lengths. In THG experiments, the second hyperpolarizabilities for long D/A-functionalized PTA oligomers attained the same saturation values as observed for the corresponding R3Si-end-capped rods. The nonlinearities measured by DFWM of the D-D and A-A substituted PTAs were found to be larger than for the silylated ones, which can be explained by the closeness of the two-photon resonance.