gebhart/patrepeval huggingface dataset:
Processing High Volume Scan Test Results for Yield Learning (2007)

Yield of nanometer-scale devices is increasingly challenging due to the increasing contribution of systematic defects that are affected by the product design itself. While inline inspection has been the conventional tool used to detect and isolate significant yield limiting mechanisms, there is a need to augment this information with the analysis of electrical test results obtained using electrical structural test of the final product. The biggest challenge is employing new methods and tools that can accommodate the voluminous amount of data that can accumulate during this process. This paper describes the methods and tools required to manage the data in both time and data-volume efficiency. The described methodology includes the levels of data accumulation and the processing at the various levels; at the tester, offline pre-processing to convert the electrical failures to the specific physical circuit elements causing the fault, and then to the yield management system
Preemptive Action (2019)

We enable preemptive force-feedback systems to speed up human reaction time without fully compromising the user's sense of agency. Typically these interfaces actuate by means of electrical muscle stimulation (EMS) or mechanical actuators; they preemptively move the user to perform a task, such as to improve movement performance (e.g., EMS-assisted drumming). Unfortunately, when using preemptive force-feedback users do not feel in control and loose their sense of agency. We address this by actuating the user's body, using EMS, within a particular time window (160 ms after visual stimulus), which we found to speed up reaction time by 80 ms in our first study. With this preemptive timing, when the user and system move congruently, the user feels that they initiated the motion, yet their reaction time is faster than usual. As our second study demonstrated, this particular timing significantly increased agency when compared to the current practice in EMS-based devices. We conclude by illustrating, using examples from the HCI literature, how to leverage our findings to provide more agency to automated haptic interfaces.
Heavy-Duty Engine Intake Manifold Pressure Virtual Sensor (2019)

Increasing demands for more efficient engines and stricter legislations on exhaust emissions require more accurate control of the engine operating parameters. Engine control is based on sensors mon ...
Optimization of the manufacturing process of macro and nano structures for power modules' interconnection (2019)

International audience
SUPRAMOLECULAR RELATIONSHIPS OF MEMBRANE ANTIGENS ON THE MURINE THYMOCYTE (1982)

The topographical relationships of Thy-1, Ly-1, Ly-2, and T200 were examined on the murine thymocyte. The inhibition of the binding of radiolabelled monoclonal antibody after incubation with unlabelled heterologous antibody was used as a measure of the proximity of the target antigens on the cell surface. On unfixed cells, prior incubation with anti-Thy-1.2 impeded the attachment of labelled anti-Ly-1, anti-Ly-2, and anti-T200. Anti-T200, but not anti-Ly-1, or anti-Ly-2, was capable of impeding the attachment of labelled anti-Thy-1.2 on unfixed cells. In general, gentle fixation with paraformaldehyde did not alter these inter-relationships. The possible functional contributions of such supramolecular relationships are discussed.
ChemInform Abstract: Supramolecular Catalysis. Part1. Non‐Covalent Interactions as a Tool for Building and Modifying Homogeneous Catalysts (2014)

Abstract Review: 605 refs.
Analysis of three-level buck-boost converter operation for improved renewable energy conversion and smart grid integration (2014)

The increased smart grid integration of renewable energy sources demands high power handling and wide controllability for the enabling power conversion technologies. The conventional energy conversion techniques are inadequate to efficiently handle the highly varying nature of renewable energy sources like wave, solar, tidal and wind. The present work examines the advantages of using a three-level buck-boost DC-DC converter to aid three-level neutral-point-clamped inverter based grid integration. There are two main reasons for using this converter. It can provide the conventional buck-boost capability at higher power levels for absorbing and conditioning the renewable source output. Besides, it can be used as a voltage balancing device to satisfy the input requirement for the three-level neutral-point-clamped inverter. The work includes complete operating range analysis of the converter for the combined buck-boost action and voltage balancing effects to understand its suitability for various applications. The converter switching modes of operation are also presented in detail along with essential example waveforms. The final results show good controllability bandwidth for the converter which makes it an attractive solution for smart grid integration of renewable energy sources.
Distribution of trinucleotide repeat sequences across a 2 Mbp region containing the Huntington's disease gene (1994)

The recent observation that the mutation underlying a number of genetic diseases including fragile sites, FRAXA and FRAXE (associated with mental retardation), myotonic dystrophy, spinal and bulbar muscular atrophy (Kennedy's disease), Huntington's disease and spinocerebellar ataxia type 1 are caused by the expansion of a trinucleotide repeat sequence will lead to interest in the identification of such sequences in regions related to other diseases. We report here the identification of all ten classes of trinucleotide repeats within a 2 Mbp region of 4p16.3 containing the Huntington's disease (HD) gene. Fifty one triplet repeats were identified and localised on a high resolution restriction map of a cosmid contig covering this region. This included the triplet repeat (CAG)n, which has subsequently been shown to be expanded in Huntington's disease patients.
Base-induced decomposition of methyl dialkylcyanodiazenecarboxylates. Transformation of ketones into nitriles, .alpha.-carbomethoxynitriles, and .alpha.-methylnitriles (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBase-induced decomposition of methyl dialkylcyanodiazenecarboxylates. Transformation of ketones into nitriles, .alpha.-carbomethoxynitriles, and .alpha.-methylnitrilesFrederick E. Ziegler and Paul A. WenderCite this: J. Am. Chem. Soc. 1971, 93, 17, 4318–4319Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://doi.org/10.1021/ja00746a052Request reuse permissionsArticle Views221Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (244 KB) Get e-Alertsclose Get e-Alerts
Envelope-Based Spatial Parameter Estimation in Directional Audio Coding (2012)

Directional Audio Coding provides an efficient description of spatial sound in terms of few audio downmix signals and parametric side information, namely the direction-of-arrival (DOA) and diffuseness of the sound. This representation allows an accurate reproduction of the recorded spatial sound with almost arbitrary loudspeaker setups. The DOA information can be efficiently estimated with linear microphone arrays by considering the phase information between the sensors. Due to the microphone spacing, the DOA estimates are corrupted by spatial aliasing at higher frequencies affecting the sound reproduction quality. In this paper we propose to consider the signal envelope for estimating the DOA at higher frequencies to avoid the spatial aliasing problem. Experimental results show that the presented approach has great potential in improving the estimation accuracy and rendering quality.
Life-threatening intoxication with methylene bis(thiocyanate): clinical picture and pitfalls. A case report (2006)

Intoxication with MBT is a potentially life-threatening intoxication causing severe methemoglobinemia and multi-organ failure. Extracorporeal liver albumin dialysis (MARS) appears to be an effective treatment to allow recovery of hepatic function.
ChemInform Abstract: Nickel‐Catalyzed [2 + 2 + 2] Cycloaddition of Two Enones and an Alkyne. (2010)

Abstract The reaction proceeds stereoselectively to give one diastereomer as a sole product.
A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo (2021)

Severe acute respiratory syndrome (SARS) is a highly lethal emerging disease caused by coronavirus SARS-CoV. New lethal animal models for SARS were needed to facilitate antiviral research. We adapted and characterized a new strain of SARS-CoV (strain v2163) that was highly lethal in 5–6 week old BALB/c mice. It had nine mutations affecting 10 amino acid residues. Strain v2163 increased IL-1α, IL-6, MIP-1α, MCP-1, and RANTES in mice, and high IL-6 expression correlated with mortality. The infection largely mimicked human disease, but lung pathology lacked hyaline membrane formation. In vitro efficacy against v2163 was shown with known inhihibitors of SARS-CoV replication. In v2163-infected mice, Ampligen™ was fully protective, stinging nettle lectin (UDA) was partially protective, ribavirin was disputable and possibly exacerbated disease, and {"type":"entrez-nucleotide","attrs":{"text":"EP128533","term_id":"135416603","term_text":"EP128533"}}EP128533 was inactive. Ribavirin, UDA and Ampligen™ decreased IL-6 expression. Strain v2163 provided a valuable model for anti-SARS research.
LAPAROSCOPIC RETROPERITONEAL LIVE DONOR RIGHT NEPHRECTOMY FOR PURPOSES OF ALLOTRANSPLANTATION AND AUTOTRANSPLANTATION (2000)

In the occasional patient requiring renal autotransplantation live donor nephrectomy can be performed laparoscopically with renal extraction and subsequent transplantation through a single standard extraperitoneal Gibson incision, thus, minimizing the overall operative morbidity. Furthermore, these data demonstrate that live donor nephrectomy of the right kidney can be performed safely using a retroperitoneal approach with an adequate length of the right renal vein obtained for allotransplantation or autotransplantation.
The three conformations of 3,5-dichloro-2-hydroxythiophenol in solution (1981)

The long-range spin–spin coupling constants for the sidechain protons in 3,5-dichloro-2-hydroxythiophenol show that the compound exists as a mixture of three conformers in CCl 4 solution at 305 K. The conformer, in which the S—H bond is held roughly perpendicular to the ring plane by an [Formula: see text] hydrogen bond, is 13% abundant. The other two conformers, of roughly equal proportions, contain an [Formula: see text] hydrogen bond. One of these has the S—H bond cis to the OH group, the other has it trans. The chemical shifts of the SH proton and of H-6 are in agreement with these conclusions. The free energy preference of the [Formula: see text] over the [Formula: see text] bond is 1140 ± 100 cal/mol at 305 K. The five-bond coupling between the sidechain protons is negative and very likely involves proximate interactions via lone pairs on oxygen and/or sulfur.
Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion (1995)

The objectives of this study were to determine whether oxidatively modified chylomicrons (oxCM) can elicit leukocyte-endothelial cell adhesion in the mesenteric microcirculation and to define the mechanisms underlying the oxCM-induced adhesive interactions. Oxidation of chylomicrons (CM) with the peroxyl radical generator 2,2'-azobis(2-amidinopropane)hydrochloride was associated with the formation of thiobarbituric acid-reactive substances and lipid hydroperoxides. Leukocyte rolling, adherence, and emigration as well as erythrocyte velocity were monitored in rat mesenteric venules infused with either native CM or oxCM. oxCM, but not native CM, increased the numbers of rolling, adherent, and emigrated leukocytes. The oxCM-induced leukocyte adherence was significantly blunted by pretreating the animals with either superoxide dismutase, a platelet-activating factor (PAF) receptor antagonist, or monoclonal antibodies (MAb) directed against either CD11/CD18 or intracellular adhesion molecule 1. A MAb against P-selectin reduced oxCM-induced leukocyte rolling but not adherence. These findings suggest that the increased plasma oxCM levels associated with ingestion of oxidized lipids may promote leukocyte adhesion through a mechanism that involves the superoxide anion, PAF, and adhesion receptors on leukocytes and endothelial cells.
Homodimerization of Human Bilirubin-Uridine-diphosphoglucuronate Glucuronosyltransferase-1 (UGT1A1) and Its Functional Implications (2001)

Genetic lesions of bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) completely or partially abolish hepatic bilirubin glucuronidation, causing Crigler-Najjar syndrome type 1 or 2, respectively. Clinical observations indicate that some mutant forms of human UGT1A1 (hUGT1A1) may be dominant-negative, suggesting their interaction with the wild-type enzyme. To evaluate intermolecular interaction of hUGT1A1, Gunn rat fibroblasts were stably transduced with hUGT1A1 cDNA. Gel permeation chromatography of solubilized microsomes suggested dimerization of hUGT1A1 in solution. Nearest-neighbor cross-linking analysis indicated that, within microsomal membranes, hUGT1A1 dimerized more efficiently at pH 7.4 than at pH 9. Two-hybrid analysis in yeast and mammalian systems demonstrated positive interaction of hUGT1A1 with itself, but not with another UGT isoform, human UGT1A6, which differs only in the N-terminal domain. Dimerization was abolished by deletion of the membrane-embedded helix from the N-terminal domain of hUGT1A1, but not by substitution of several individual amino acid residues or partial deletion of the C-terminal domain. A C127Y substitution abolished UGT1A1 activity, but not its dimerization. Coexpression of mutagenized and wild-type hUGT1A1 in COS-7 cells showed that the mutant form markedly suppressed the catalytic activity of wild-type hUGT1A1. Homodimerization of hUGT1A1 may explain the dominant-negative effect of some mutant forms of the enzyme.
Suppl Fig 7 from Intrathecal Viral Vector Delivery of Trastuzumab Prevents or Inhibits Tumor Growth of Human HER2-Positive Xenografts in Mice (2023)

&lt;p&gt;AAV9.trastuzumab tumor prophylaxis in the setting of continuous NK cell depletion&lt;/p&gt;
Joint resource allocation and receiver map estimation in underlay cognitive radios (2013)

Conventional spectrum sensing schemes can detect active transmitters but not passive receivers, which have to be nevertheless protected from excessive interference whenever their bands are reused. In this paper, a resource allocation scheme for underlay cognitive radios is formulated, taking into account uncertainty of both propagation gains and locations of incumbent receivers. The performance of orthogonal access by secondary users is maximized under average interference constraints, using channel statistics and maps that pin-point areas where primary receivers are likely to reside. These maps are tracked using a Bayesian approach, based on a 1-bit message sent by the primary system whenever a communication disruption occurs due to interference.
Signed Network Modeling Based on Structural Balance Theory (2018)

The modeling of networks, specifically generative models, has been shown to provide a plethora of information about the underlying network structures, as well as many other benefits behind their construction. There has been a considerable increase in interest for the better understanding and modeling of networks, and the vast majority of existing work has been for unsigned networks. However, many networks can have positive and negative links (or signed networks), especially in online social media. It is evident from recent work that signed networks present unique properties and principles from unsigned networks due to the added complexity, which pose tremendous challenges on existing unsigned network models. Hence, in this paper, we investigate the problem of modeling signed networks. In particular, we provide a principled approach to capture important properties and principles of signed networks and propose a novel signed network model guided by Structural Balance Theory. Empirical experiments on three real-world signed networks demonstrate the effectiveness of the proposed model.
Testing concurrent programs: a formal evaluation of coverage criteria (2002)

While the literature on testing sequential programs is rich, there has been very little work on testing concurrent programs. One major trend in testing sequential code is to define program-based, test data adequacy criteria. Different criteria are often evaluated using a set of properties which are intended to capture the intuition of what constitutes good testing. The work considers the adaptation of techniques for evaluating sequential program-based coverage criteria to an abstract concurrent language. The authors define two sequential and two concurrent program-based criteria which are evaluated with respect to a set of properties. Based upon their analysis, they are able to define new criteria which combine the sequential and concurrent aspects of the program. They also propose a new property that has no parallel in the field of sequential testing. Finally, they discuss the application of the new criteria to the testing of concurrent programs.
An in vitro model to optimize dose scheduling of multimodal radioimmunotherapy and chemotherapy: Effects of p53 expression (2003)

Several reports have appeared on the use of combined radioimmunotherapy (RAIT) and chemotherapy. The choice of drug to use with RAIT and how to space the two treatments has not been completely addressed. Because every patient's cancer presents with a specific molecular phenotype, we hypothesized that it may be necessary to tailor therapy based on specific gene expression. We addressed how the form of expression of a single gene, the p53 tumor suppressor, would impact the choice of agents, as well as sequence and spacing of agents. p53 regulates cell cycle arrest to allow for DNA repair after therapy-induced small DNA damage or induction of apoptosis if damage is great and has been shown to affect chemo- and radiosensitivity of cancer cells. We established 3 stable p53 transfectants of the SKOV-3 p53null parental line (p53(wt), p53(143mut) or p53(273mut)). p53 expression was confirmed using flow cytometry, using the DO1 pan-p53 Ab and the PAb240 anti-p53mut Ab. The colorimetric MTT assay was then used to measure dose-dependent growth inhibition from single modality chemotherapy (doxorubicin, carboplatin, paclitaxel or topotecan) or radioimmunotherapy (90Y-RS-7 IgG anti-EGP1). The % survival vs. log [drug] were plotted to obtain the IC50. We then used a matrix design in which we varied the sequence of the first and second modality of treatment and the spacing between the 2 treatments to determine the most synergistic and antagonistic combinations for the parental SKOV-3 and each of the 3 transfectants. The IC50 for each therapeutic agent varied as a function of the form of p53 expressed. For example, of the 4 lines, the p53wt transfectant was the most resistant to topotecan and the 143mut was the most resistant to carboplatin. The 273mut was quite sensitive to both doxorubicin and paclitaxel, whereas the p53null and wt were not. For multimodal treatments, most combinations of RAIT and chemotherapy resulted in a 30-40% growth inhibition (GI) and were either additive or moderately antagonistic. The 3 best (>60% GI) and 3 worst (<25% GI) combinations were identified and were unique to the parental p53null and to the 3 transfectants. Certain combinations showed clear synergy and others were antagonistic, with the first treatment modality blocking the growth inhibitory effects of the second treatment modality. The form of p53 expressed affects chemosensitivity and radiosensitivity and will influence optimal multimodal therapy with RAIT and chemotherapy and the dose-schedule (sequential with RAIT first or with drug first) when more than 1 agent is used.
An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels (2006)

The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of vertebrate cells via N,N'-diacetylchitobiose lectin-like activity. In the present study, we show that CCF-induced membrane depolarization results in the release of TNF, IL-6 and nitric oxide (NO) by macrophages via nuclear factor-kappaB signaling. Interestingly, our data suggest that TNF contributes, through lectin-saccharide interaction, to the secretion of IL-6 and NO induced by CCF. This experimental non-physiological setting based on the interaction of an invertebrate defense lectin with vertebrate cells involved in the innate immune response may have highlighted an evolutionarily ancient mechanism of macrophage activation in vertebrates.
Detecting physiologic fluctuations in the S-nitrosohemoglobin micropopulation: triiodide versus 3C (2006)

It is now established that erythrocytes can dilate blood vessels by generating NO bioactivity.[1][1]-[3][2] Singel and Stamler[2][3] have proposed that this dilator function is conveyed by a micropopulation of hemoglobins (Hb's) that have undergone the addition of NO to a critical cysteine (cysβ93
Modelling binaural receivers in finite difference simulation of room acoustics (2013)

Binaural room impulse responses are important for auralisation as well as for objective research in room acoustics. In geometrical room simulation methods, obtaining such responses is easily achieved by convolving each computed reflection tap with a corresponding pre-measured angle-dependent head-related impulse response. Unfortunately, employing such an approach in wave based methods is challenging due to temporal overlap of room reflections in the calculated response. One alternative is to physically embed a listener geometry in the grid. Whilst this method is straightforward, it requires voxelization of a geometrically-complex object. Furthermore, with non-conformal boundary conditions, the voxelized geometry is sample-rate dependent, meaning that numerical consistency may become compromised. In this paper we discuss the merits and drawbacks of embedding different listener geometries in the grid, ranging from a simple rigid sphere to a fully featured laser-scan of a Kemar mannikin. Results are analysed in terms of generated auditory cues, and are discussed in light of room acoustics modelling using the FDTD method.