gebhart/patrepeval huggingface dataset:
Abstract A62: Three pronged strategy to enhance pharmacological effectiveness of pHLA targeting TcEs (2022)

Abstract T-cell engagers redirect T cells to a tumor specific target leading to lysis of tumor cells with demonstrated therapeutic benefit in hematological and solid tumors. Most T-cell engagers in development focus on surface exposed tumor antigens as targets. However, HLA/peptide complex directed (TCR mimic) T cell engagers enable targeting of tumour associated intracellular proteins and therefore broaden the cancer antigen space for T cell engagers. Potency and specificity are key attributes for the design of TCR mimic T cell engagers. Here, we employed a three pronged strategy to enhance pharmacological effectiveness of pHLA targeting TcEs: i) innovative bispecific formats employing avidity effect ii) TCRm affinity maturation by pHLA-Fv model based library design and phage display iii) pHLA-Fv crystal structure based affinity maturation in silico. The different strategies and combinations thereof enabled and improved lysis of tumor cells by T cell engager and informed on the structure-function relation of TCR mimic T cell engager. Citation Format: Nicolas Sabarth, Paul Adam, Sandeep Kumar, Yanyun Liu, Renate Konopitzky, Jark Boettcher, Tadas Panavas. Three pronged strategy to enhance pharmacological effectiveness of pHLA targeting TcEs [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr A62.
The decarbonylation reaction of imidazole‐2‐carbaldehydes in ethanol (1978)

Abstract Imidazole‐2‐carbaldehydes in hot ethanol undergo a decarbonylation reaction involving nucleophilic attack of the alcohol on the carbonyl to form the corresponding imidazole and ethyl formate.
Ring‐Rearrangement Metathesis of Bicyclic Amino Acid Derivatives. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021 (2022)

The Advanced Prostate Cancer Consensus Conference is a forum for discussing current diagnosis and treatment options for patients with advanced prostate cancer. An expert panel votes on predefined questions focused on the most clinically relevant areas for treatment of advanced prostate cancer for which there are gaps in knowledge. The voting results provide a practical guide to help clinicians in discussing treatment options with patients as part of shared decision-making.
On-Chip Spectrophotometry for Bioanalysis Using Nanophotonic Devices (2010)

We measure optical absorption from color-producing enzymatic reactions for biochemical antigen detection using a microscale optofluidic device. The microring cavity can detect absorbance with high sensitivity while requiring only nanoliter volumes of reagants.
Link selection schemes for avoiding channel contention (2004)

This paper describes methods to reduce channel contention during distributed setup of high-speed connections in a mesh network of Cross-Connects (XCs) (R.D. Doverspike et al., 1999). A particular aspect of contention addressed here is when two different connection requests arrive on a pair of adjacent XCs and they choose the same restoration channels from spare inventory. Such a contention problem is often referred to as "glare". This paper gives channel selection methods that considerably reduce glare, while at the same time maintaining large groups of channels (for future high speed connections) across multiple, parallel links. We establish the benefit of our approach in a typical intercity backbone network. As shown in the simulation results, our channel selection mechanism can eliminate almost all the glare compared to the previously known algorithms, "Best-fit" and "Hi-Lo".
The APACHE III score as preoperative indicator of patient outcome in liver transplantation after fulminant hepatic failure. (2011)

The major advantage of the APACHE III score is that its application and prognostic ability is independent from etiology of FHF. This accurate and reproducible evaluation system could be useful to identify patients with poor outcome.
Metrology with μCT: precision challenge (2008)

Over the last years computed tomography (CT) with conventional x-ray sources has evolved from imaging method in medicine to a well established technology for industrial applications in the field of material science, microelectronics, geology, etc. By using modern microfocus and nanofocus&#174; X-ray tubes, parts can be scanned with sub-micrometer resolutions. Currently, micro-CT is used more and more as a technology for metrological applications. Especially if complex parts with hidden or difficult accessible surfaces have to be measured, CT offers big advantages comparing with conventional tactile or optical coordinate measuring machines (CMMs): high density of measurement points and fast capturing of the complete sample's geometry. When using this modern technology the question arises how precise a CT based CMM can measure in comparison to conventional CMMs? To characterize the metrological capabilities of a tactile or optical CMM, internationally standardized characteristics like length measurement error and probing error are used. To increase the acceptance of CT as a metrological method, the definition and usage of these parameters is important. In this paper, an overview of the process chain in CT based metrology will be given and metrological characteristics will be described. With the help of a special material standard designed and calibrated by PTB-National Metrology Institute of Germany-the influence of methods for beam hardening correction and for surface extraction on the metrological characteristics will be analyzed. It will be shown that with modern micro-CT systems length measurement error of less than 1&mu;m for an object diameter of 20 mm can be reached.
Characterizing the Internal Morphology of Transition Regions in Large-Scale Extrusion Deposition Additive Manufacturing (2021)

A dual-hopper feed system that was developed for the Big Area Additive Manufacturing (BAAM) system allows for transitioning between different materials while maintaining continuous deposition. This technique creates a step-change in material feedstock by switching the pellet feeding system to alternate which hopper is currently supplying material, allowing for multi-material construction. The step-change in feedstock material produces a transition region that is characterized by a compositional gradient and blended internal morphology. Initial cross-sectional imaging of the transition region revealed a non-homogenous blend of materials with distinct domains of each material, likely due to incomplete mixing within the screw. This study used a carbon fiber reinforced acrylonitrile butadiene styrene (CF-ABS) and an unfilled ABS to characterize the internal structure and to correlate it to mechanical performance by tracking microhardness across cross-sections of the transition region.
Adsorption of poly(2-vinylpyridine)-poly (styrene) block copolymers from toluene solutions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption of poly(2-vinylpyridine)-poly (styrene) block copolymers from toluene solutionsEdward Parsonage, Matthew Tirrell, Hiroshi Watanabe, and Ralph G. NuzzoCite this: Macromolecules 1991, 24, 8, 1987–1995Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ma00008a041https://doi.org/10.1021/ma00008a041research-articleACS PublicationsRequest reuse permissionsArticle Views798Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymeric Nanolayers as Actuators for Ultrasensitive Thermal Bimorphs (2006)

Polymeric nanolayers are introduced here as active, thermal-stress mediating structures facilitating extremely sensitive thermal detection based upon the thermomechanical response of a bimaterial polymer-silicon microcantilever. To maximize the bimaterial bending effect, the microcantilever bimorph is composed of stiff polysilicon, with a strongly adhered polymer deposited via plasma-enhanced chemical vapor deposition. The polymer layers with thickness ranging from 20 to 200 nm possess a rapid and pronounced response to temperature fluctuations due to intrinsic sensitive thermal behavior. We show that by taking advantage of the thermal stresses generated by the huge mismatch of material properties in the polymer-silicon bimorph, unprecedented thermal sensitivities can be achieved. In fact, the temperature resolution of our bimaterial microcantilevers approaches 0.2 mK with thermal sensitivity reaching 2 nm/mK; both parameters are more than an order of magnitude better than the current metal-ceramic design. This new hybrid platform overcomes the inherently limited sensitivity of current sensor designs and provides the basis to develop the ultimate uncooled IR microsensor with unsurpassable sensitivity.
On-chip networks from a networking perspective (2012)

In this paper, we present network-on-chip (NoC) design and contrast it to traditional network design, highlighting similarities and differences between the two. As an initial case study, we examine network congestion in bufferless NoCs. We show that congestion manifests itself differently in a NoC than in traditional networks. Network congestion reduces system throughput in congested workloads for smaller NoCs (16 and 64 nodes), and limits the scalability of larger bufferless NoCs (256 to 4096 nodes) even when traffic has locality (e.g., when an application's required data is mapped nearby to its core in the network). We propose a new source throttling-based congestion control mechanism with application-level awareness that reduces network congestion to improve system performance. Our mechanism improves system performance by up to 28% (15% on average in congested workloads) in smaller NoCs, achieves linear throughput scaling in NoCs up to 4096 cores (attaining similar performance scalability to a NoC with large buffers), and reduces power consumption by up to 20%. Thus, we show an effective application of a network-level concept, congestion control, to a class of networks -- bufferless on-chip networks -- that has not been studied before by the networking community.
A cryogenic Yb:YAG regenerative amplifier pumped, mJ-class, 1 kHz, 3 µm wavelength ultrafast OPCPA (2022)

We report a robust long-term stable &gt;19mJ energy, 1kHz repetition rate cryogenic Yb:YAG regenerative amplifier and its application in pumping a mJ-class, 3µm wavelength OPCPA. We highlight the benefits of cryo-Yb:YAG over alternative systems.
Suppression of Akt Signaling Induces Fas Ligand Expression: Involvement of Caspase and Jun Kinase Activation in Akt-Mediated Fas Ligand Regulation (2002)

Fas and Fas ligand (FasL) expression has been detected in chronic vascular lesions, and Fas-mediated apoptosis of vascular smooth muscle cells (VSMC) may influence the integrity of the atherosclerotic plaque. Here we report that FasL is not expressed by normal VSMC, but its expression is upregulated by stresses that induce apoptosis, including serum deprivation, exposure to the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin, and ablation of Akt signaling. Conversely, constitutive activation of Akt signaling diminished FasL expression in VSMC cultures exposed to low-mitogen media or wortmannin. Under conditions of suppressed PI 3-kinase/Akt signaling, VSMC apoptosis was partially inhibited by treatment with neutralizing antibody against FasL. Suppression of Akt signaling increased the activity of c-Jun N-terminal kinase, and transduction of dominant-negative c-Jun inhibited FasL induction under these conditions. Diminished Akt signaling promoted the cleavage of caspase 3, and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant-negative caspase 9 or the caspase 8 inhibitor CrmA. Similarly, induction of FasL by the Akt-regulated forkhead transcription factor FKHRL1 was dependent upon caspase and c-Jun activation. Taken together, these results indicate that the sequential activation of caspase 3 and c-Jun participates in the induction of FasL under conditions of suppressed Akt signaling or FKHRL1 activation and that FasL participates in a positive-feedback loop to promote cell death under conditions of cellular stress.
Collagen-targeted molecular MR imaging of liver fibrosis in a mouse model (2012)

1576 Objectives Liver fibrosis is the end common pathway of chronic liver injuries. Liver biopsy, the current clinical gold standard for assessment of fibrosis, is invasive and has sampling errors, and is not optimal for screening, monitoring, or clinical decision-making. Fibrosis is characterized by excessive accumulation of extracellular matrix proteins including type I collagen. We hypothesize that a MR probe targeted to type I collagen will enable noninvasive staging of hepatic fibrosis. Methods Mice were administered carbon tetrachloride or vehicle for 6 - 18 weeks resulting in mild to severe liver fibrosis. Mice were imaged prior to and following administration of a Gd-based probe targeted to type I collagen or with non-specific Gd-DTPA. Following imaging, animals were euthanized and the livers analyzed for Gd concentration, hydroxyproline (total collagen), and stained with Sirius Red for fibrosis and scored by a board certified pathologist blinded to the study. Results MRI signal enhancement showed strong correlations with liver hydroxyproline concentration and with Ishak scoring for fibrosis. Ex vivo analysis of gadolinium showed positive linear correlations with hydroxyproline and Ishak scoring. Unenhanced MRI or Gd-DTPA enhanced MRI could not distinguish fibrotic animal from controls. Conclusions Molecular MRI with a collagen specific probe shows feasibility for non-invasive staging of liver fibrosis. Research Support Sanofi-Aventis and NCI (CA140861)
Fabrication and electro-optic characteristics of polymer-stabilized V-mode ferroelectric liquid crystal display and intrinsic H-V-mode ferroelectric liquid crystal displays: their application to field sequential fullcolor active matrix liquid crystal displays (2004)

Shunsuke KobayashiJun XuHirokazu FurutaYuji MurakamiSatoru KawamotoMasafumi Oh-kouchiTokyo University of ScienceLiquid Crystal Institute and the GraduateSchool of Engineering ScienceYamaguchi, OnodaYamaguchi 756-0884, JapanHiroshi HasebeHaruyoshi TakatsuDainippon Ink. and Chemical Ind.Ina-machi, Kitaadachi-gunSaitama 362-8577, JapanAbstract. We fabricate ferroelectric liquid crystal display (FLCD) de-vices exhibiting a thresholdless V-shaped switching by adopting a me-sogenic liquid crystal polymer stabilization and also FLCDs exhibitinghalf-V-shaped switching using an undoped FLC material. These FLCDsare respectively called polymer-stabilization (PS)-V-mode FLCDs and in-trinsic H-V-mode FLCDs. By using especially developed polyimide ma-terials such as RN-1199 and RN-1411 series (from Nissan Chem., Ind.)for the surface alignment and together with a well-controlled rubbingtechnique, photoalignment, and ion-beam alignment, we succeed in fab-ricating zigzag defect-free FLCDs. In particular, the PS-V-mode FLCDfabricated in this way exhibits continuous operation with a high contrastratio of 700:1, and the intrinsic H-V-mode FLCD has good temperaturestability by using the combined alignment technique. Particularly, a ﬁeld-sequential full-color (FS-FC) LCD using PS-V-mode FLCD shows goodlong-term stability for a continual operation. Using these FLCDs, we alsodevelop several prototype models of FS-FC active matrix LCDs with thespeciﬁcation of video graphics arrays (VGAs) and extended graphicsarrays (XGAs), where we take advantage of their high-speed response(time constants 100 to 500 ms).
Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines (2018)

1: ESGE suggests using contrast-enhanced computed tomography (CT) as the first-line imaging modality on admission when indicated and up to the 4th week from onset in the absence of contraindications. Magnetic resonance imaging (MRI) may be used instead of CT in patients with contraindications to contrast-enhanced CT, and after the 4th week from onset when invasive intervention is considered because the contents (liquid vs. solid) of pancreatic collections are better characterized by MRI and evaluation of pancreatic duct integrity is possible. Weak recommendation, low quality evidence. 2: ESGE recommends against routine percutaneous fine needle aspiration (FNA) of (peri)pancreatic collections. Strong recommendation, moderate quality evidence. FNA should be performed only if there is suspicion of infection and clinical/imaging signs are unclear. Weak recommendation, low quality evidence. 3: ESGE recommends initial goal-directed intravenous fluid therapy with Ringer's lactate (e. g. 5 - 10 mL/kg/h) at onset. Fluid requirements should be patient-tailored and reassessed at frequent intervals. Strong recommendation, moderate quality evidence. 4: ESGE recommends against antibiotic or probiotic prophylaxis of infectious complications in acute necrotizing pancreatitis. Strong recommendation, high quality evidence. 5: ESGE recommends invasive intervention for patients with acute necrotizing pancreatitis and clinically suspected or proven infected necrosis. Strong recommendation, low quality evidence.ESGE suggests that the first intervention for infected necrosis should be delayed for 4 weeks if tolerated by the patient. Weak recommendation, low quality evidence. 6: ESGE recommends performing endoscopic or percutaneous drainage of (suspected) infected walled-off necrosis as the first interventional method, taking into account the location of the walled-off necrosis and local expertise. Strong recommendation, moderate quality evidence. 7: ESGE suggests that, in the absence of improvement following endoscopic transmural drainage of walled-off necrosis, endoscopic necrosectomy or minimally invasive surgery (if percutaneous drainage has already been performed) is to be preferred over open surgery as the next therapeutic step, taking into account the location of the walled-off necrosis and local expertise. Weak recommendation, low quality evidence. 8: ESGE recommends long-term indwelling of transluminal plastic stents in patients with disconnected pancreatic duct syndrome. Strong recommendation, low quality evidence. Lumen-apposing metal stents should be retrieved within 4 weeks to avoid stent-related adverse effects.Strong recommendation, low quality evidence.
Targeting serotonin and norepinephrine receptors in stress urinary incontinence (2004)

Stress urinary incontinence (SUI) in women is prevalent, and there are no globally developed or widely approved drugs for the disease. One strategy for improving urinary continence is to augment the function of the urethral rhabdosphincter through neuropharmacology. The present review describes the innervation of the urethra, and the role of the central nervous system in controlling nerve activity. Targeting serotonin and norepinephrine (or noradrenaline) receptors in Onuf's nucleus is shown to augment the function of the urethral rhabdosphincter by increasing pudendal nerve efferent activity. It is proposed that the ability of serotonin and norepinephrine to enhance the effects of glutamate (the primary excitatory neurotransmitter for pudendal sphincter motor neurons) while having no direct effects of their own, allow facilitation of rhabdosphincter activity during urine storage while allowing complete relaxation during micturition. Duloxetine, a potent and balanced dual serotonin (5-HT)-norepinephrine reuptake inhibitor (SNRI), potentiates these physiological effects of endogenous serotonin and norepinephrine (by inhibiting the reuptake of these neurotransmitters in the pre-synaptic element) and thereby enhances the central nervous system's natural continence control mechanisms.
Improvement in retinal venous oxygen saturation after panretinal photocoagulation is predictive of progression of proliferative diabetic retinopathy (2016)

We performed a prospective, interventional clinical study on patients with proliferative diabetic retinopathy (PDR) in order to investigate changes in retinal oximetry before and three months after panretinal photocoagulation (PRP) and to correlate this to PDR-activity.<br/><br/>Thirty-nine eyes from 34 patients with diagnosed PDR were included. We performed wide-field fluorescein angiography (WFA) (Optomap; Optos PLC., Dunfermline, Scotland, UK) and retinal oximetry (Oxymap model T1; Oxymap, software version 2.4.2, Reykjavik, Iceland) at baseline and three months after PRP by a navigated laser (NAVILAS®; OD-OS GmbH, Berlin, Germany). At follow-up, WFA was used to evaluate PDR activity and patients were categorized into two groups: progression (Group 1, n=10) or stability/regression of PDR (Group 2, n=29).<br/>Retinal oximetry measurements were performed on optic disc centered images using the in-built software that automatically marked the vessels; one larger arteriole and venule in each quadrant were identified for measurements, pre-specified protocol. <br/><br/>At baseline, mean age and duration of diabetes were 54.8± years and 21.7± years, respectively, and 72% were male. HbA1c was 67±mmol/mol, and the mean blood pressure was 152/84mmHg. Retinal arterial and venous saturation was 96.7% and 67.4%, respectively. <br/>Patients in Group 1 and 2 did not differ in baseline retinal arterial and venous oxygen saturation, number of laser spots delivered, total laser energy delivered, or change in retinal arterial oxygen saturation after PRP (-1.2% vs. -0.4%, p=0.92).<br/>In contrast, as compared to baseline, the improvement in retinal vein oxygen saturation was significantly different between the groups (+2.7% for Group 1 vs. -3.5% for Group 2, p=0.02). <br/>In a multivariable logistic regression analysis, adjusted for the mentioned variables, the change in retinal vein oxygen saturation between baseline and follow-up independently predicted PDR-progression (OR 1.31 per 1% increment in retinal venous oxygen saturation between baseline and follow-up, 95% CI 1.03-1.61, p=0.03).<br/><br/>Lack of reduction in retinal venous oxygen saturation after PRP was independently associated with PDR-activity. This might reflect absence in reduction in vascular endothelial growth factor (VEGF) and could be a potential non-invasive marker of disease activity.<br/><br/><br/>
Phosphonylated 8-Azahypoxantines as Acyclic Nucleotide Analogs (2015)

GRAPHICAL ABSTRACTPhosphonylated 8-Azahypoxantines as Acyclic Nucleotide AnalogsAll authorsAnna Zdzienicka, Dominique Schols, Graciela Andrei, Robert Snoeck & Iwona E. Głowackahttps://doi.org/10.1080/10426507.2015.1054931Published online:10 December 2015