gebhart/patrepeval huggingface dataset:
P2‐071: Development and validation of a salivary tau biomarker in Alzheimer disease (2015)

Abnormally increased hyperphosphorylated tau (p-tau) and total tau (t-tau) are found in the brain and cerebrospinal fluid (CSF) of Alzheimer Disease (AD) patients and correlate with degree of cognitive decline. Increased levels of p-tau and t-tau are also found in tauopathies such as frontotemporal dementia (FTD) and Progressive Supranuclear Palsy (PSP). Hence, a biomarker for abnormal brain tau could become critical in delineating which mildly impaired patients may be candidates for future anti-tau therapy. An inexpensive, accurate, and easily quantifiable tau biomarker, which can also be frequently repeated, will remain a major goal in the field of dementia. A salivary biomarker offers a promising way of achieving this ideal. We have been pursuing the potential for a salivary tau biomarker that could be performed in a basic laboratory setting. Our studies have revealed that salivary tau can be detected by simple Western blot analysis. We have found that tau in healthy adult saliva is on the order of picograms and that the amount does not vary significantly across subjects. Furthermore, using site-specific p-tau antibodies, we have determined that the phosphorylation sites of salivary tau are similar to those of tau in the brain. Furthermore, saliva from 10 AD and 10 mild cognitive impairment (MCI) subjects showed significant elevation of p-tau and t-tau compared to normal subjects. These data indicate that salivary tau offers the exciting potential to emerge as a simple and cost-effective early AD biomarker. We acknowledge the support of the W. Garfield Weston Foundation in this research.
Imidazole‐Analogues of 6‐Epicastanospermine and of 3,7a‐Diepialexine (1991)

Abstract The chiral bicyclic imidazol derivatives 7 and 8 were obtained from D‐glucose derivative 9 by a sequence of selective protection/deprotection and intramolecular S N 2 reactions. Triols 7 and 8 are analogues of 6‐epica‐stanospermine ( 4 ) and of 3,7a‐diepialexine ( 6 ), respectively, and are potential glycosidase inhibitors. However, their anti‐HIV activity proved to be only marginal.
Optimal multi-channel equalizer design for underwater acoustic communications (2014)

Adaptive equalization is a widely used method of mitigating the effects of multipath propagation and Doppler spreading in underwater acoustic communication channels. This paper examines some specifics associated with the design of a multi-channel equalizer for time-varying underwater acoustic channels. More specifically, we study how the number of sensors and separation between them impact the equalization performance of a sparse time-varying channel. We develop a theoretical model and, to illustrate the ideas, find the optimal equalizer for a particular arrival model. Finally, we show how the BER performance depends on sensor separation via processing experimental data.
533: Targeting Isolectin B4-Binding C-Fiber Afferent Neurons in Dorsal Root Ganglia for the Treatment of Neurogenic Detrusor Overactivity in Spinal Cord Injury (2004)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 1:00 - 5:00 pm1 Apr 2004533: Targeting Isolectin B4-Binding C-Fiber Afferent Neurons in Dorsal Root Ganglia for the Treatment of Neurogenic Detrusor Overactivity in Spinal Cord Injury Jun Nishiguchi, Katsumi Sasaki, Satoshi Seki, Michael B. Chancellor, William C. De Groat, Hiromi Kumon, and Naoki Yoshimura Jun NishiguchiJun Nishiguchi More articles by this author , Katsumi SasakiKatsumi Sasaki More articles by this author , Satoshi SekiSatoshi Seki More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , William C. De GroatWilliam C. De Groat More articles by this author , Hiromi KumonHiromi Kumon More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37795-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "533: Targeting Isolectin B4-Binding C-Fiber Afferent Neurons in Dorsal Root Ganglia for the Treatment of Neurogenic Detrusor Overactivity in Spinal Cord Injury." The Journal of Urology, 171(4S), p. 142 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 142 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jun Nishiguchi More articles by this author Katsumi Sasaki More articles by this author Satoshi Seki More articles by this author Michael B. Chancellor More articles by this author William C. De Groat More articles by this author Hiromi Kumon More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF DownloadLoading ...
Triple Source Isolation: Results from a North Sea Field Test (2018)

Summary Seabed seismic data have proven critical for addressing long-standing challenges in seismic imaging both for exploration and reservoir development and management. Significant advances have been made to bring down the cost and increase efficiency for deploying and retrieving ocean bottom nodes, such that the efficiency on the source side increasingly becomes the bottleneck for efficient operations. We present results from a recent field test in the North Sea where three source lines were acquired simultaneously from a single vessel without compromising inline sampling such that the fold is doubled compared to conventional flip-flop acquisition. The acquisition and processing technology is partially based on the science of signal apparition that allows for an optimally large part of the data corresponding to the individual sources to be exactly recovered while accurately reconstructing the full bandwidth beyond the region in frequency-wavenumber space of exact reconstruction. For the triple source field test presented here, the productivity increases 50% compared to conventional flip-flop acquisition or three-fold compared to conventional single-source full-fold acquisition suitable for reservoir development and management applications.
Electrical stability of inkjet-patterned organic complementary inverters measured in ambient conditions (2009)

Complementary organic inverters were fabricated by inkjet patterning of both the metal contacts and the semiconductors. Bottom-gate, bottom-contact organic thin-film transistors with Ta2O5-polymer bilayer dielectrics, inkjet-printed silver electrodes, and inkjet-printed organic semiconductors exhibit hole and electron mobilities as high as ∼10−2 cm2/V s. Complementary inverters based on these transistors operate in ambient and exhibit a gain of −4.4 with supply voltage VDD=+20 V and −3 dB cutoff at 100 kHz with a load of 0.02 pF. The electrical stability of the inverters was evaluated for analog and digital operation, and a noise margin ≥1.1 V at VDD=+15 V was measured with bias-stress effects included.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling (2023)

&lt;p&gt;Supplemental Figure S3. Effects of dorsomorphin on NK cells phenotype and functionality.&lt;/p&gt;
New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies (2023)

Semisynthetic modifications of natural products have bestowed us with many anticancer drugs. In the present work, a natural product, eugenol, has been modified synthetically to generate new anticancer agents. The final compounds were structurally confirmed by NMR, IR, and mass techniques. From the cytotoxicity results, compound <b>17</b> bearing morpholine was found to be the most active cytotoxic agent with IC<sub>50</sub> 1.71 (MCF-7), 1.84 (SKOV3), and 1.1 μM (PC-3) and a thymidylate synthase (TS) inhibitor with an IC<sub>50</sub> of 0.81 μM. Further cellular studies showed that compound <b>17</b> could induce apoptosis and arrest the cell cycle at the S phase in PC-3 carcinoma. The docking study strongly favors compound <b>17</b> to be a TS inhibitor as it displayed a similar interaction to 5-fluorouracil. The in silico pharmacokinetics and DFT computational studies support the results obtained from docking and biological evaluation and displayed favorable pharmacokinetic profile for a drug to be orally available. Compound <b>17</b> was found to be a promising TS inhibitor which could suppress DNA synthesis and consequently DNA damage in prostate cancer cells.
Preparation of the Disperse Systems of Sulfathiazole-Polyvinylpyhrolidone by Mechanical Activation (1994)

AbstractThe potential value of solid-state dispersions of insoluble drugs in water-soluble matrices is known to bring about enhancement of solubility, dissolution rate and bioavailability of the drugs. The conventional methods of preparation of solid dispersions such as fusion or solvent technique are somewhat limited. The method of mechanical activation analogous to that which is employed in the mechanical alloying method may be used in preparation of dispersions of organic solids. In this paper, the method of mechanical activation is applied to obtain a solid-state dispersion of sulfathiazole in polyvinylpyrrolidone. The mechanical treatment of sulfathiazole with polyvinylpyrrolidone in a planetary ball mill transfers crystalline drug into amorphous state, the process being accompanied by formation of hydrogen bonds of sulfathiazole with matrice. The apparent solubility and rate of solvation of sulfathiazole were greatly increased if it was previously mechanically treated with polyvinyl -pyrrolidone. The release of sulfathiazole from solid dispersions with polymer to drug ratio of 1:3, 1:1, 3:1 was examined, a polymer to drug ratio of 3:1 gave the highest solubility.
Metamaterials in applications: tunable filters and resonant detectors. (2012)

Abstract not provided.
A Manifesto for Future Generation Cloud Computing: Research Directions for the Next Decade (2017)

The Cloud computing paradigm has revolutionised the computer science horizon during the past decade and has enabled the emergence of computing as the fifth utility. It has captured significant attention of academia, industries, and government bodies. Now, it has emerged as the backbone of modern economy by offering subscription-based services anytime, anywhere following a pay-as-you-go model. This has instigated (1) shorter establishment times for start-ups, (2) creation of scalable global enterprise applications, (3) better cost-to-value associativity for scientific and high performance computing applications, and (4) different invocation/execution models for pervasive and ubiquitous applications. The recent technological developments and paradigms such as serverless computing, software-defined networking, Internet of Things, and processing at network edge are creating new opportunities for Cloud computing. However, they are also posing several new challenges and creating the need for new approaches and research strategies, as well as the re-evaluation of the models that were developed to address issues such as scalability, elasticity, reliability, security, sustainability, and application models. The proposed manifesto addresses them by identifying the major open challenges in Cloud computing, emerging trends, and impact areas. It then offers research directions for the next decade, thus helping in the realisation of Future Generation Cloud Computing.
3‐Azabicyclo[3.1.0]hex‐1‐ylamines by Ti‐Mediated Intramolecular Reductive Cyclopropanation of α‐(N‐Allylamino)‐Substituted N,N‐Dialkylcarboxamides and Carbonitriles. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
DSC and13C‐NMR studies of the imidazole‐accelerated reaction between epoxides and phenols (1989)

Abstract The imidazole‐accelerated reaction between epoxides and phenols has been studied through DSC and 13 C‐NMR of model compounds. The selectivity of the accelerator has been found to be strongly dependent on its concentration. If a low amount of accelerator is used, the reaction takes place almost exclusively through the addition of phenols to epoxides even if the latter are used in excess. However, a larger amount of accelerator will cause the secondary hydroxyls (produced by the main reaction) to react with the epoxides. In any case, the lower reactivity of the secondary hydroxyls prevents them from reacting to any significant extent as long as there are any phenols present. When polyfunctional resins are used, the effect of the selectivity of the reaction on the properties of the crosslinked network is very clear. If a low amount of accelerator is used (to promote only the epoxy–phenol reaction), the maximum glass transition temperature ( T g ) occurs when the epoxides and phenols are stoichiometrically balanced, reaching 178°C. However, when an excess of epoxides over phenols is used, along with a larger amount of accelarator, the maximum T g increases its value to 199°C.
Jointing Edge Labeling and Geometrical Constraint for Lane Detection and its Application to Suspicious Driving Behavior Analysis (2011)

This paper presents a novel lane detection scheme for detecting and tracking various lanes directly from videos in real time. The key contribution of this paper is to propose a new edge labeling scheme for labeling each edge point to different types. Even under different lighting and weather conditions, different lane segments still can be effectively extracted from the labeling result. Only the subtraction and counting operators are involved in the labeling process. It is also flexible for detecting lanes with different types especially from an interchange area. To filter out false lane segments, this paper uses a pinhole camera model to derive a geometrical constraint for lane verification. The constraint is invariant to shadows and lighting changes. Thus, each lane line can be verified and then detected more accurately from roads. Since lanes seldom change their colors during two adjacent frames, we propose a kernel-based technique for tracking them even fragmented into pieces of segments. Then, different lanes can be more efficiently detected and tracked from videos captured under various lighting and weather conditions. With the lane information, different dangerous driving events like lane departure can be easily analyzed for driver assistances. All the involved operations are very simple and effective for hardware implementation. Extensive experimental results reveal the feasibility and superiority of the proposed approach in lane detection.
Thermal heliox proteome. High-temperature heliox does not cause destruction of human respiratory system cells (2020)

Most exhaled proteins are the same before, after the procedure, and for three hours of relaxation. The results obtained demonstrate the relative safety of the use of high temperature heliox as a therapeutic agent.
Clinical trial: impact of prior infliximab therapy on the clinical response to certolizumab pegol maintenance therapy for Crohn’s disease (2010)

Certolizumab pegol is an effective maintenance therapy in Crohn's disease regardless of prior infliximab use. Efficacy is higher in patients receiving CZP therapy as a first-line biologic, but approximately 50% of infliximab-experienced patients benefited from second-line CZP therapy.
Development of High Content Imaging Assays for Lethal Viral Pathogens (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
Tissue Kallikrein Reverses Insulin Resistance and Attenuates Nephropathy in Diabetic Rats by Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B and Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathways (2007)

We previously reported that iv delivery of the human tissue kallikrein (HK) gene reduced blood pressure and plasma insulin levels in fructose-induced hypertensive rats with insulin resistance. In the current study, we evaluated the potential of a recombinant adeno-associated viral vector expressing the HK cDNA (rAAV-HK) as a sole, long-term therapy to correct insulin resistance and prevent renal damage in streptozotocin-induced type-2 diabetic rats. Administration of streptozotocin in conjunction with a high-fat diet induced systemic hypertension, diabetes, and renal damage in rats. Delivery of rAAV-HK resulted in a long-term reduction in blood pressure, and fasting plasma insulin was significantly lower in the rAAV-HK group than in the control group. The expression of phosphatidylinositol 3-kinase p110 catalytic subunit and the levels of phosphorylation at residue Thr-308 of Akt, insulin receptor B, and AMP-activated protein kinases were significantly decreased in organs from diabetic animals. These changes were significantly attenuated after rAAV-mediated HK gene therapy. Moreover, rAAV-HK significantly decreased urinary microalbumin excretion, improved creatinine clearance, and increased urinary osmolarity. HK gene therapy also attenuated diabetic renal damage as assessed by histology. Together, these findings demonstrate that rAAV-HK delivery can efficiently attenuate hypertension, insulin resistance, and diabetic nephropathy in streptozotocin-induced diabetic rats.
ChemInform Abstract: The Electroreduction of Oxygen on Pyrolytic Graphite. (1987)

Abstract It is shown that the O 2 reduction in alkaline solution on pyrolytic graphite (PG) is influenced by the nature and concentration of active surface groups.
The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis (2017)

The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study. We applied monomeric periostin, total periostin detected by a conventional kit, and the conventional biomarkers-KL-6, SP-D, and LDH-to diagnose IPF and to predict its short-term progression as estimated by short-term changes of %VC and % DL, CO. Moreover, we compared the fraction ratios of monomeric periostin to total periostin in IPF with those in other periostin-high diseases: atopic dermatitis, systemic scleroderma, and asthma. Monomeric periostin showed the greatest ability to identify IPF comparable with KL-6 and SP-D. Both monomeric and total periostin were well correlated with the decline of %VC and % DL, CO. Clustering of IPF patients into high and low periostin groups proved useful for predicting the short-term progression of IPF. Moreover, the relative ratio of monomeric periostin was higher in IPF than in other periostin-high diseases. Measuring monomeric periostin is useful for diagnosing IPF and predicting its short-term progression. Moreover, the ratio of monomeric periostin to total periostin is elevated in IPF compared to other periostin-high diseases.
XML search (2006)

The development of approaches to access XML content has generated a wealth of issues in information retrieval (IR) and database (DB) (e.g., [2, 15, 17, 20, 19, 47, 26, 32, 24]). While the IR community has traditionally focused on searching unstructured content, and has developed various techniques for ranking query results and evaluating their effectiveness, the DB community has focused on developing query languages and efficient evaluation algorithms for highly structured content. Recent trends in DB and IR research demonstrate a growing interest in merging IR and DB techniques for accessing XML content. Support for a combination of "structured" and full-text search for effectively querying XML documents was unanimous in a recent panel at SIGMOD 2005 [3], and is being widely studied in the IR community [20].
Next generation of long-reach coherent WDM/TDM access network leveraging tunable directly modulated hybrid silicon lasers (2013)

We demonstrate 10 Gbit/s symmetric WDM/TDM PON based on high output power hybrid III-V/silicon tunable laser. At the OLT, coherent detection allows long-reach transmission over 100-km single-mode fiber with high optical budget beyond 35 dB.
18F-labeled fluorouracil positron emission tomography and the prognoses of colorectal carcinoma patients with metastases to the liver treated with 5-fluorouracil (1998)

Patients with high 18F-FU uptake values are more likely to achieve at least stabilization of disease with planned chemotherapy. 18F-FU PET may be a valuable new tool for determining, prior to 5-FU-based chemotherapy, which patients are likely to have good responses and prolonged survival.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk (2011)

Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (&gt;= 140 mm Hg systolic blood pressure or &gt;= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Prefiltered space-time M-BCJR equalizer for frequency-selective channels (2002)

This paper addresses the problem of soft equalization for space-time-coded transmissions over frequency-selective fading channels. The structure of the space-time code is embedded in the channel impulse response for efficient joint equalization and decoding. The proposed equalization/decoding approach uses a prefilter to concentrate the effective channel power in a small number of taps followed by a reduced-complexity maximum a posteriori probability (MAP) equalizer/decoder to produce soft decisions. The prefilter introduces residual intersymbol interference which degrades the performance of MAP when applied to the trellis of the shortened channel. However, the shape of the overall shortened channel impulse response allows the M-algorithm to approximate the prefiltered MAP performance with a small number of states. Based on this general framework, we investigate several enhancements such as using different prefilters for the forward and backward recursions, concatenating two trellis steps during decoding, and temporal oversampling. The performance is evaluated through simulations over the EDGE typical urban channel.