gebhart/patrepeval huggingface dataset:
Massive MIMO with Optimal Power and Training Duration Allocation (2014)

We consider the uplink of massive multicell multiple-input multiple-output systems, where the base stations (BSs), equipped with massive arrays, serve simultaneously several terminals in the same frequency band. We assume that the BS estimates the channel from uplink training, and then uses the maximum ratio combining technique to detect the signals transmitted from all terminals in its own cell. We propose an optimal resource allocation scheme which jointly selects the training duration, training signal power, and data signal power in order to maximize the sum spectral efficiency, for a given total energy budget spent in a coherence interval. Numerical results verify the benefits of the optimal resource allocation scheme. Furthermore, we show that more training signal power should be used at low signal-to-noise ratio (SNRs), and vice versa at high SNRs. Interestingly, for the entire SNR regime, the optimal training duration is equal to the number of terminals.
The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank (2016)

RNA quality and PDXs engraftment rate were adversely affected by prolonged ischemia times. Proper tissue collection and processing reduce failure rate. Overall, NSCLC BioBanking represents an innovative modality, which can be successfully executed in routine clinical settings, when stringent Standard Operating Procedures are adopted.
Joint stochastic routing and scheduling for multihop wireless ad-hoc networks (2007)

We consider the problem of finding multihop routes in a wireless ad-hoc network jointly with scheduling transmission times of different information flows. Taking into account the unreliable nature of wireless channels, we derive a joint stochastic routing-scheduling algorithm whereby schedules and routes are selected at random with certain probabilities that we optimize. We prove that if there exists a set of (random) schedules and routes ensuring that all queues in the network are stable, our protocol converges to one such set. Our approach to the problem is to: i) characterize the set of scheduling - routing policies guaranteeing that all queues in the network are stable; ii) show that this can be reduced to finding a set of auxiliary variables in a convex polyhedron; and iii) use dual decomposition techniques to develop an algorithm converging to a point inside this convex polyhedron.
Progress in extremely high brightness LED-based light sources (2017)

Although the maximum brightness of LEDs has been increasing continuously during the past decade, their luminance is still far from what is required for multiple applications that still rely on the high brightness of discharge lamps. In particular for high brightness applications with limited étendue, e.g. front projection, only very modest luminance values in the beam can be achieved with LEDs compared to systems based on discharge lamps or lasers. With dedicated architectures, phosphor-converted green LEDs for projection may achieve luminance values up to 200-300 Mnit. In this paper we report on the progress made in the development of light engines based on an elongated luminescent concentrator pumped by blue LEDs. This concept has recently been introduced to the market as ColorSpark High Lumen Density LED technology. These sources outperform the maximum brightness of LEDs by multiple factors. In LED front projection, green LEDs are the main limiting factor. With our green modules, we now have achieved peak luminance values of 2 Gnit, enabling LED-based projection systems with over 4000 ANSI lm. Extension of this concept to yellow and red light sources is presented. The light source efficiency has been increased considerably, reaching 45-60 lm/W for green under practical application conditions. The module architecture, beam shaping, and performance characteristics are reviewed, as well as system aspects. The performance increase, spectral range extensions, beam-shaping flexibility, and cost reductions realized with the new module architecture enable a breakthrough in LED-based projection systems and in a wide variety of other high brightness applications.
Pathways to Antigen Expression after Oral Delivery of an Adenovirus-Based Vaccine (2015)

International audience
Redox Sensitivity of NMDA Receptors (2003)

The redox modulatory sites of the NMDA receptor consist of critical cysteine residues, which when chemically reduced, increase the magnitude of NMDA-evoked responses. In contrast, after oxidation, NMDA-evoked responses are decreased in size. In recent years, as endogenous sources of oxidizing and reducing agents have been discovered, redox modulation of protein function has been recognized to be an important physiologic, as well as pathologic mechanism for many cell types. For our purposes, I will confine this review of redox modulation to covalent modification of sulfhydryl (thiol) groups on protein cysteine residues of native NMDA receptors. Of note, considerable recent work has focused on the use of recombinant NMDA receptor subunits and site-directed mutagenesis to identify the critical cysteine residues involved in this redox modulation, but these recombinant methods will not be reviewed here. For a recent summary of the molecular data, see ref. . If the cysteine sulfhydryls possess a sufficient redox potential, oxidizing agents can react to form adducts on single thiol groups, or if two free sulfhydryl groups are vicinal (in close proximity), disulfide bonds may possibly be formed. Reducing agents can regenerate free sulfhydryl (—SH) groups by donating electron(s). Considering endogenous redox agents, in addition to the usual suspects, including glutathione, lipoic acid, and reactive oxygen species, nitric oxide and its redox-related species have recently come to the fore.
Design of a Human-Powered Roll Stabilization Attachment for Utilitarian Two-Wheeled Vehicles (2019)

Abstract This paper describes the motivation and development of a human-powered roll stabilization attachment for utilitarian two-wheeled vehicles. The proposed design has been built and tested by the authors in both on- and off-road conditions. It provides balance by providing a rolling platform underneath the two-wheeled vehicle (motorcycle) for the user to push against with their feet. This platform is placed under the driver’s sitting position and is towed from a three degree-of-freedom joint behind the front axle (i.e. one of the implementations uses a ball hitch joint). Fifty eight percent of the world’s motorcycles are in Asia Pacific, and Southern and Eastern Asia. In most of those countries, motorcycles greatly outnumber cars and many of these motorcycles function as utility vehicles. The uses of motorcycles include transportation of goods on the bike frame, transportation of goods on a trailer, and even pulling agricultural implements in farms. If no modifications are made to the motorcycle, at slow speeds operators of motorcycles must drag their feet on the ground and lightly push upwards as needed to retain balance. Attaching conventional outrigger wheels, similar to a motorcycle side-car, can negate some of the advantages of motorcycles that users value by: (A) preventing leaning into turns when rigid outriggers arms are used, (B) significantly increasing complexity and mass when outrigger arms mounted on suspension systems are used, and (C) increasing the vehicle’s width such that it can no longer travel between car lanes or between rows of growing crop. An additional design consideration for balancing motorcycles is the user’s need for quick conversion between a statically balanced vehicle and a vehicle can lean dynamically in turns, for example for someone who wishes to operate a motorcycle on farms but also travel quickly between agricultural fields. This conversion convenience is affected not only by the ease of attaching and detaching the balancing system but also by the ability to comfortably carry on the balancing system on the motorcycle even when it is not being used, such that it can be deployed when it is needed. This paper describes a design for a human-powered roll stabilization attachment that address these concerns and other identified user needs. It also provides with general equations to design similar human-powered roll stabilization systems for motorcycles.
Simple autoclave systems for fibre reinforced composite components (1988)

Two simple autoclave systems have been developed to produce standard tubular and flat fibre composite test specimens, using existing laboratory facilities to effect pressure, vacuum and curing temperature. An inadequate vacuum resulted in internal defects such as delamination. The choise of the vacuum bagging material and the correct application of the release agent used affected the finished surfaces of the pieces. With an intact and adequate vacuum, and the right bagging film, good quality specimens were produced using a manual layup epoxy-fibreglass system, having strengths of up to 850±65 MPa for an alternating 090 continuous fibre ply system, and 220 ± 18 MPa for a continuus random ply system, with a thickness variation for flat plate specimen of 5 ±0·05 mm.
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells (2023)

G protein-coupled receptors (GPCRs) modulate diverse cellular signaling pathways and are important drug targets. Despite the availability of high-resolution structures, the discovery of allosteric modulators remains challenging due to the dynamic nature of GPCRs in native membranes. We developed a strategy to covalently tether drug fragments adjacent to allosteric sites in GPCRs to enhance their potency and enable fragment-based drug screening in cell-based systems. We employed genetic code expansion to site-specifically introduce noncanonical amino acids with reactive groups in C-C chemokine receptor 5 (CCR5) near an allosteric binding site for the drug maraviroc. We then used molecular dynamics simulations to design heterobifunctional maraviroc analogues consisting of a drug fragment connected by a flexible linker to a reactive moiety capable of undergoing a bioorthogonal coupling reaction. We synthesized a library of these analogues and employed the bioorthogonal inverse electron demand Diels-Alder reaction to couple the analogues to the engineered CCR5 in live cells, which were then assayed using cell-based signaling assays. Tetherable low-affinity maraviroc fragments displayed an increase in potency for CCR5 engineered with reactive unnatural amino acids that were adjacent to the maraviroc binding site. The strategy we describe to tether novel drug fragments to GPCRs should prove useful to probe allosteric or cryptic binding site functionality in fragment-based GPCR-targeted drug discovery.
Science at the Interface of Chemistry and Biology at the University of Texas Southwestern Medical Center (2007)

ADVERTISEMENT RETURN TO ISSUEPREVIn FocusNEXTScience at the Interface of Chemistry and Biology at the University of Texas Southwestern Medical CenterJoseph M. Ready, * and Kristen W. Lynch, View Author Information Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390* Corresponding author, [email protected]Cite this: ACS Chem. Biol. 2007, 2, 8, 512–514Publication Date (Web):August 17, 2007Publication History Received25 July 2007Accepted25 July 2007Published online17 August 2007Published inissue 1 August 2007https://pubs.acs.org/doi/10.1021/cb700153hhttps://doi.org/10.1021/cb700153hnewsACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views335Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biochemistry,Biology,Molecular structure,Organic chemistry,Students Get e-Alerts
Modeling processing of silicone rubber: Liquid versus hard silicone rubbers (2010)

Abstract The processing of hard and liquid silicone rubbers (LSR) are compared by means of modeling and simulation. The curing process for both, hard and liquid silicone, are modeled using the auto‐catalytic Kamal‐Sourour model and a nonlinear regression method is used to find the kinetic parameters. The fitted kinetic model is then combined with the heat balance equations to simulate real processing conditions. Both resins are compared in terms of process performance and consistency of the final part. The results show that even though hard silicone rubbers are less expensive resins, its processing conditions present several issues of consistency and quality control when compared with LSR. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119:1864–1871, 2011
P-100 Anti-Drug Antibodies Separate Responses of Markers of Inflammation (C-Reactive Protein, Fecal Calprotectin) in Crohnʼs Disease Patients Treated with Certolizumab Pegol (2014)

C-reactive protein (CRP) and fecal calprotectin (FCP) are markers of inflammatory disease activity in Crohn's disease (CD).1,2 Tumor necrosis factor inhibitors (anti-TNFs) decrease inflammation and have been shown to decrease CRP and/or FCP in patients with CD. The presence of anti-drug antibodies (Abs) to anti-TNFs decrease the drug concentration in plasma. The aim of this exploratory analysis was to investigate whether occurrence of anti-certolizumab pegol (CZP) Abs is correlated with a significant decrease in CZP concentrations, and whether CRP and FCP as markers of inflammation are influenced by that decrease in patients with CD enrolled in the PRECiSE 3 (P3) study. P3 was a 7-year open-label extension study in patients who had completed a 26-week blinded qualifying study (QS) of CZP. In P3 (NCT00552058), patients received CZP 400 mg every 4 weeks from Week 2 to Week 364. CRP and FCP concentrations were measured at multiple time points over time, from screening of QS to Week 364 for CRP/Week 258 for FCP. Ab-positive was defined as plasma Ab concentration >2.4 unit/mL in ≥1 measurement from screening of QS through safety follow up. CRP and FCP concentrations were assessed against plasma CZP concentrations at the corresponding visits. At Week 0 of P3 (N = 594), 444 patients were negative for anti-CZP Abs and 150 were positive. Median CRP concentrations at screening of QS were 7.0 mg/L in the CZP Ab-negative group and 7.5 mg/L in the CZP Ab-positive group; median FCP concentrations were 337.0 µg/g stool for the CZP Ab-negative group and 281.0 µg/g stool in the CZP Ab-positive group. The geometric mean of CZP trough plasma concentrations markedly differed between the 2 groups on all of the assessments made with concentrations ranging between approximately 8-12 ug/mL (Ab-negative) and 2-4 ug/mL (Ab-positive). CZP Ab-negative patients had lower CRP levels and higher corresponding CZP trough concentrations; their median CRP decreased to <5 mg/L by week 6 of the P3 study and remained low (between 3 and 4 mg/L) through the last measurements done at week 364. Median CRP levels in CZP Ab-positive patients were approximately 50% higher through week 106 of the study compared to Ab-negative patients. After that period, the difference was less pronounced (Figure 1a). Data for FCP were similar to CRP data. After 26 weeks of treatment, patients who were CZP Ab-negative with higher CZP concentrations, also had median FCP concentrations that were considerably lower compared to the FCP levels in CZP Ab-positive patients. (Figure1b). CD patients who were anti-CZP Ab-negative had markedly higher CZP concentrations throughout the 7-year study period and lower levels of CRP and FCP. As CRP and FCP are robust markers of intestinal inflammation and response to therapy, these data are of important clinical utility. 1. Sandborn WJ. Dig Dis. 2012;30(suppl 3):140–144. 2. D'Incà R, et al. Clin Exp Gastroenterol. 2014;7:151–161.
Multi-layer spike-in spike-out representation of Hippocampus circuitry (2013)

One of the frontier research of neuroscience focuses on replacing the damaged human Hippocampus regions with a prosthetic device replicating Hippocampus neural functionality. Since neural cognition in general and memory formation in particular are the result of neural processing in multiple layers of neural circuitries, it is crucial to develop neural models mimicking the same topology principals. This paper presents a two later spike-in-spike-out model of the Hippocampus neural circuitry with the emphasis on providing a methodology for tuning parameters of the model for DG→CA1 spike-in-spike-out transformation. Volterra series expansion with Laguerre basis functions represents layers of the circuit, in which network layers are communication by spikes. Utilizing the input-output recordings of the Hippocampus, the novel model predicts spike timing of the CA1 neurons. The simulation result justifies that neurobiological recording of DG→CA1 can be successfully generated by utilizing the methodology of this paper.
Assignment and Quantification of 2-Aminopyridine Derivatized Oligosaccharide Isomers Coeluted on Reversed-Phase HPLC/MS by MSn Spectral Library (2004)

2-Aminopyridine (PA)-derivatized oligosaccharides from IgG were analyzed by using reversed-phase HPLC/mass spectrometry (RP-HPLC/MS) and a MS(n) spectral library, in particular, focusing on two pairs of isomers incompletely separated or coeluted in chromatograms. We previously reported that MS(n) spectral matching considering both major fragment ions (m/z) and intensities is useful and applicable to the structural assignment of PA-oligosaccharide isomers. In this study, MS(n) spectral matching based on the MS(n) spectral library was applied to the assignment of these PA-oligosaccharide isomers in IgG. Its usefulness was investigated by comparing it to the conventional two-dimensional mapping method based on retention time indexes. Specifically, we focus on the assignment and quantification of the isomers, which are coeluted in chromatograms. From this, we propose a new method using MS(n) spectral matching and the working curve on which are plotted the relative intensities of selected fragment ions in their MS(2) spectra versus various mixtures of the isomers. This new method demonstrated that the obtained quantities coincide very well with those estimated after separating by a combination of lectin and reversed-phase columns. This means that separation by RP-HPLC/MS is greatly simplified because complete separation of the isomers is no longer required. Application of this new method was tested by using the two other pairs of fucosylated and nonfucosylated PA-oligosaccharides from IgG. The results showed that this method works for them as well.
Visual Interaction Platform. (2000)

Abstract: The Visual Interaction Platform (VIP) is a Natural User Interface (NUI) that builds on human skills of real world object manipulation and allows unhindered human-human communication in a collaborative situation. The existing VIP is being extended towards the VIP-3 in order to allow support for new kinds of interactions. An example of a natural augmented reality interface to be realized on the VIP-3 is a pen-and-paper interface that combines properties of real pen-and-paper with typical computer functionality for flexible re-use of information. Two ongoing research projects on the VIP-3 are also briefly discussed: the first project develops supporting tools for early architectural design, while the second project aims at supporting 3D interaction for navigating and browsing through multidimensional data sets.
Dynamic spectrum sharing between active and passive users above 100 GHz (2022)

Abstract Sixth-generation wireless networks will aggregate higher-than-ever mobile traffic into ultra-high capacity backhaul links, which could be deployed on the largely untapped spectrum above 100 GHz. Current regulations however prevent the allocation of large contiguous bands for communications at these frequencies, since several narrow bands are reserved to protect passive sensing services. These include radio astronomy and Earth exploration satellites using sensors that suffer from harmful interference from active transmitters. Here we show that active and passive spectrum sharing above 100 GHz is feasible by introducing and experimentally evaluating a real-time, dual-band backhaul prototype that tracks the presence of passive users (in this case the NASA satellite Aura) and avoids interference by automatically switching bands (123.5–140 GHz and 210–225 GHz). Our system enables wide-band transmissions in the above-100-GHz spectrum, while avoiding harmful interference to satellite systems, paving the way for innovative spectrum policy and technologies in these crucial bands.
Design and Implementation of a Three-Phase Buck-Type Third Harmonic Current Injection PFC Rectifier SR (2012)

In this paper, a three-phase buck-type unity power factor rectifier is designed for high-power electric vehicle battery charging mains interfaces. The characteristics of the converter, named the Swiss Rectifier (SR), including the principle of operation, modulation strategy, suitable control structure, and dimensioning equations are described in detail. Exemplarily, a 7.5 kW hardware prototype is then designed based on the derived analytical expressions and the feasibility of the SR concept is demonstrated by the means of experimental measurements. Finally, the SR is compared with a conventional six-switch buck-type ac–dc power conversion. According to the results, the SR is the topology of choice for a buck-type PFC.
Surgeons produce innovative ideas which are frequently lost in the labyrinth of patents☆ (2009)

Thoracic and cardiovascular surgery are innovative specialties that regularly recruit the latest technological developments into their armoury of devices and equipment. The introduction of new technology is dependant on patents; an important but single component of intellectual property. Patents enable the attribution of rights to concepts, ideas and inventions and this facilitates ownership, subsequent licensing and overall management of innovation and its outcome. It is not just thoracic and cardiovascular surgery, but the healthcare world in general that experiences ongoing technological evolution; so to remain contemporary, it is important that those in positions of responsibility are familiar with the relevant processes. This requires basic medico-legal knowledge and may be entwined with significant financial responsibility. Penetrating clinical, academic and industrial environments, informed awareness of patents also contributes to important leadership skills, encouraging the incorporation of innovation into the professional milieu. We aim to present through this manuscript an overview of these issues in order to promote awareness of patents within thoracic and cardiovascular surgery using a descriptive and practical approach.