gebhart/patrepeval huggingface dataset:
Determination of active hydrogen in organic compounds by chemical ionization mass spectrometry (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of active hydrogen in organic compounds by chemical ionization mass spectrometryDonald F. Hunt, Charles N. McEwen, and R. A. UphamCite this: Anal. Chem. 1972, 44, 7, 1292–1294Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/ac60315a055https://doi.org/10.1021/ac60315a055research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data from Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies (2023)

&lt;div&gt;Abstract&lt;p&gt;Targeted imaging and therapy approaches based on novel prostate-specific membrane antigen (PSMA) inhibitors have fundamentally changed the treatment regimen of prostate cancer. However, the exact mechanism of PSMA inhibitor internalization has not yet been studied, and the inhibitors' subcellular fate remains elusive. Here, we investigated the intracellular distribution of peptidomimetic PSMA inhibitors and of PSMA itself by stimulated emission depletion (STED) nanoscopy, applying a novel nonstandard live cell staining protocol. Imaging analysis confirmed PSMA cluster formation at the cell surface of prostate cancer cells and clathrin-dependent endocytosis of PSMA inhibitors. Following the endosomal pathway, PSMA inhibitors accumulated in prostate cancer cells at clinically relevant time points. In contrast with PSMA itself, PSMA inhibitors were found to eventually distribute homogeneously in the cytoplasm, a molecular condition that promises benefits for treatment as cytoplasmic and in particular perinuclear enrichment of the radionuclide carriers may better facilitate the radiation-mediated damage of cancerous cells. This study is the first to reveal the subcellular fate of PSMA/PSMA inhibitor complexes at the nanoscale and aims to inspire the development of new approaches in the field of prostate cancer research, diagnostics, and therapeutics.&lt;/p&gt;Significance:&lt;p&gt;This study uses STED fluorescence microscopy to reveal the subcellular fate of PSMA/PSMA inhibitor complexes near the molecular level, providing insights of great clinical interest and suggestive of advantageous targeted therapies.&lt;/p&gt;&lt;/div&gt;
Diphenyliodonium Salts with Diazoxide Group for A Photo-acid Generator (2004)

We designed diphenyliodonium salts with diazoxide group for a photo-acid generator (PAG) in chemically amplified resists. The absorption coefficients at 365 nm for the new PAGs were 103 -104 orders, originating in diazoxide structure. The quantum yield for acid generation irradiating 365 nm wavelength light of diphenyliodonium 1-diazo-2-hydroxynaphthalene-4-sulfonate (AZO-DPI) and diphenyliodonium 1-diazo-2-hydroxy-6-nitronaphthalene-4-sulfonate (NO2-AZO-DPI) was 0.21 and 0.14, respectively. The thermal stability of AZO-DPI and NO2-AZO-DPI were 144.2 and 153.2°C, respectively. The photosensitivity of AZO-DPI and NO2-AZO-DPI irradiating 365 nm wavelength light in polymer bearing ethoxyethyl protecting group were 120 and 98 mJ/cm2, respectively. The diphenyliodonium salt is the promising PAG sensitizing for 365 nm chemically amplified resists.
Cloning and expression of murine interleukin-1 receptor antagonist in macrophages stimulated by colony-stimulating factor 1 (1991)

Colony-stimulating factor 1 (CSF-1) can act on mature macrophages to modulate their production of inflammatory cytokines. A cDNA encoding the interleukin-1 receptor antagonist (IL-1Ra) was cloned by subtractive hybridization from a CSF-1-stimulated murine macrophage cell line, sequenced, and expressed in mammalian and bacterial cells. Mouse IL-1Ra is a 22-Kd glycoprotein that is 76% identical to its human counterpart, shows considerably less similarity to IL-1 alpha and IL-1 beta, and competes with IL-1 alpha for binding to the type I IL-1 receptor normally expressed on T cells and fibroblasts. CSF-1 treatment of mouse bone marrow-derived macrophages led to a rapid and sustained increase in IL-1Ra mRNA during the G1 phase of the cell cycle as well as to increases in mRNAs encoding IL-1 alpha and IL-1 beta. Cycloheximide inhibited CSF-1-induced IL-1 alpha mRNA synthesis, but augmented IL-1 beta mRNA production and did not affect induction of IL-1Ra mRNA. No IL-1Ra mRNA was observed in CSF-1-stimulated mouse fibroblasts engineered to express CSF-1 receptors, demonstrating that its regulation depends on cell context and can be dissociated from the proliferative response. In agreement, bacterial lipopolysaccharide, a nonmitogenic activator, also induced IL-1Ra and IL-1 mRNAs in macrophages. Unlike IL-1 alpha and beta, IL-1Ra contains a signal peptide. The kinetics of its induction and its ability to gain access to the secretory compartment imply that IL-1Ra may be secreted more efficiently than IL-1, and suggest that macrophages both positively and negatively regulate the IL-1 response.
Singlet-singlet energy transfer studies of the internal organization of nucleosomes (1980)

We report the measurement of two specific protein to DNA distances in several conformational states of core nucleosomes by singlet-singlet energy transfer. A distance of 50-53 A separates each DNA terminus from cysteine-110 of chicken erythrocyte histone H3 in the native nucleosome. This cysteine residue must therefore be located very near the center of the nucleosome. The H3-DNA distance remained nearly constant in several unfolded forms of the core particles, as found in very low salt, in 0.6 M NaCl, and in high urea. Furthermore, it was shown that each DNA end lies within 32 A of cysteine-73 of Arbacia lixula sperm histone H4 in both the compact and the low-salt unfolded forms of the nucleosome. Because of the invariance of the two measured distances in the various conformational states of the nucleosome, we conclude that the cysteine-containing C-terminal segments of histones H3 and H4 maintain a very strong and close association with the terminal positions of the 146 base pair nucleosomal DNA. This binding may provide the primary interactions necessary for the folding of DNA into nucleosomes and for protection of 146 base pair nucleosomes from further nuclease digestion.
Controlling Plane-Jet Flame by a Fluidic Oscillation Technique (2013)

A plane-jet flame was manipulated by passing the fuel jet through a jet-impingement fluidic oscillator. The plane fuel jet bifurcated into two streams of self-sustained pulsating jets in the cavity of the fluidic oscillator and issued out of two slits on the exit plane of the fluidic oscillator. The oscillation of the bifurcated plane fuel jets caused the flame behavior and combustion characteristics to change significantly compared with the corresponding behavior and characteristics of a nonoscillating plane-jet flame. The oscillation frequency, flame behavior, thermal structure, and combustion-product distributions of the fluidic-oscillator flame were experimentally examined and compared with the nonoscillating plane-jet flame. The flame behavior was studied with instantaneous and long-exposure photography. The temperature distributions were measured with a fine-wire thermocouple. The combustion-product concentrations were detected with a gas analyzer. The results showed that the length and width of the fluidic-oscillator flame were reduced by approximately 45% and enlarged by approximately 40%, respectively, compared with the length and width of the nonoscillating plane-jet flame. The transverse temperature profiles of the fluidic-oscillator flame presented a wider spread than did the plane-jet flame. The fluidic-oscillator flame’s maximum temperature was approximately 100 °C higher than that of the plane-jet flame. The fluidic-oscillator flame presented a larger CO2 concentration and a smaller unburned C3H8 concentration than did the plane-jet flame. The experimental results indicated that the combustion in the fluidic-oscillator flame was more complete than that in the plane-jet flame.
Carbohydrate Meeting Spring 1993: First Circular Structure, Function and Synthesis of Glycoconjugates (1993)

Carbohydrate Meeting Spring 1993: First Circular Structure, Function and Synthesis of Glycoconjugates Get access T. Ogawa, T. Ogawa 1Saltama Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Potter, B. Potter 2Bath Search for other works by this author on: Oxford Academic PubMed Google Scholar J. van Boom, J. van Boom 3Leiden Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Downes, P. Downes 4Dundee Search for other works by this author on: Oxford Academic PubMed Google Scholar M. McConville, M. McConville 5Dundee Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Hounsell, E. Hounsell 6Harrow Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Ashford, D. Ashford 7Oxford Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Stanley, P. Stanley 8New York Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Drickamer, K. Drickamer 9New York Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Gallagher, T. Gallagher 10Bath Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more N. Turner, N. Turner 11Exeter Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Perez, S. Perez 12Nantes Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Bush, A. Bush 13Baltimore Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Gidley, M. Gidley 14Bedford Search for other works by this author on: Oxford Academic PubMed Google Scholar O. Hindsgaul, O. Hindsgaul 15Alberta Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Lehmann, J. Lehmann 16Freiburg Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Gravestock, M. Gravestock 17Bracknell Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Gigg, R. Gigg 18London Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Dell, A. Dell 19London Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Hall, L. Hall 20Cambridge Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Crout D. Crout 21Warwick Search for other works by this author on: Oxford Academic PubMed Google Scholar Glycobiology, Volume 3, Issue 1, February 1993, Page 5, https://doi.org/10.1093/glycob/3.1.5-c Published: 01 February 1993
Design and Validation of a GPS Logger System for Recording Aerially Deployed Herbicide Ballistic Technology Operations (2014)

Herbicide ballistic technology (HBT) is an electro-pneumatic delivery system designed for administering 17.3-mm herbicide-filled projectiles (e.g., paintballs) to visually acquired weed targets. Currently, HBT is being deployed from a Hughes 500D helicopter platform in aerial surveillance operations to eliminate satellite invasive weed populations in remote natural watershed areas of Maui (HI, USA). In an effort to improve operations, we have integrated GPS and other sensor hardware into the electropneumatic device for instantaneous recording of time, origin, and trajectory of each projectile discharged by the applicator. These data are transmitted wirelessly to a custom android application that displays target information in real time both textually and graphically on a map.
Changes to TMC and its Editorial Board (2011)

STARTING in 2012, TMC will be going paperless! The journal will be published in a form called OnlinePlus (http:// www.computer.org/onlineplus), in which the format and pagination of a paper issue is maintained, since citation indices and academic promotion processes heavily depend upon these. Subscribers will, at a lower subscription rate, be given access to the full online archive. They will also receive, once every quarter, a small booklet containing abstracts of published articles from three issues and a CD-ROM containing electronic copies of these articles. I would like to take the opportunity to thank Dr. Mani Srivastava for his phenomenal service to the community as Editor-in-Chief. During his tenure, he has raised the quality and the visibility of the journal and has managed its growth and evolution in impressive fashion. He has left big shoes to fi ll! I would also like to welcome our new Associate Editor-in-Chief, Dr. Ram Ramanathan, who is Principal Research Scientist at Raytheon BBN. The journal has grown in size and stature over the years and has reached a point where it can benefi t greatly from a second person at the helm, and Ram has graciously agreed to take on that responsibility. Ram has played a leadership role in the fi eld of mobile computing for nearly two decades, and was also a former associate editor of TMC. Our Editorial Board continues to evolve, and I would like to take this opportunity to introduce the new members, whose biographies appear below, and thank the outgoing ones. I would like to welcome aboard several new Associate Editors to fi ll gaps left by Associate Editors whose terms expired, and to strengthen the Editorial Board’s expertise in emerging areas. It is my pleasure to introduce Fan Bai, Ranveer Chandra, Olivier Dousse, Michael Fang, Christina Fragouli, Allen MacKenzie, and Mihail Sichitiu. Together, they bring expertise in vehicular networks, cognitive radios, cellular networks, network information theory, game theory, location management, and localization. They also increase our international and industry representation. I would like to thank them for taking time from their busy schedules to volunteer for this important service to the community. Finally, I would like to acknowledge the contributions of four Associate Editors whose terms ended recently or who stepped down for personal reasons: Samir Das, Aura Ganz, Srikanth Krishnamurthy, and Marwan Krunz. They brought unique perspectives and expertise to the journal, and we are the richer for it. I greatly appreciate the dedication, diligence, and promptness they have shown during their terms. TMC continues to be a very desirable publication venue for mobile and wireless computing and networking, and this would not be possible without the support of our readers and authors, the members of the Editorial Board, the Steering Committee, and the Computer Society staff. I look forward to hearing feedback from our readership and receiving suggestions for ways to improve the journal in the coming years.
Statistical Modeling of Integrated Sensors for Automotive Applications (2018)

In this paper we show a way to solve the need for improved, faster and more reliable development of integrated sensor systems. This can only be achieved when production and calibration uncertainties are considered already in design phase. In our approach, we employ statistical methods base on known or estimated variances and correlations of system parameters. This allows us to model the system completely (under the assumption of Gaussian distributions), by using a reduced parameter set which only contains the aforementioned parameters and their covariance matrix. Since the proposed methodology is especially valuable for the automotive industry, a case-study is presented where we applied this methodology to an integrated automotive magnetic angle sensor system. We can thus show how effectively and reliably this methodology solves statistical requirement needs already in an early development-phase.
Supplementary Table 6 from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation (2023)

&lt;p&gt;Statistics over-represented peptides HLA class I&lt;/p&gt;
Molecular Signatures of Localized Clear Cell Renal Cell Carcinoma to Predict Disease-Free Survival after Nephrectomy (2009)

A molecular signature consisting of five molecular markers (Ki-67, p53, endothelial VEGFR-1, epithelial VEGFR-1, and epithelial VEGF-D) can predict DFS for localized clear cell RCC. The prognostic ability of the signature and nomogram may be superior to clinical and pathologic factors alone and may identify a subset of localized patients with aggressive clinical behavior. Independent, external validation of the nomogram is required.
Effect of the alkyl chain length of C70-PCBX acceptors on the device performance of P3HT : C70-PCBX polymer solar cells (2010)

A series of soluble C70-derivatives (C70-PCBX) was synthesized by varying the alkyl chain length of the adduct (X = R1, R3, R5, R7, R9) attached to the C70-polyhedron. After blending with P3HT, bulk heterojunction polymer solar cells were fabricated, and their performances were evaluated. As the alkyl chain length increased, phase segregation between the P3HT and C70-PCBX domains in the P3HT : C70-PCBX blend active layer increased, which enhanced the device performance to a moderate degree. The performance enhancement may have been due to the increased solubility and self-aggregation of C70-PCBX as a result of the longer alkyl chains, as was predicted by molecular simulations. The nanomorphologies of the P3HT : C70-PCBX active layers offered an explanation for the trend in solar cell performance: as the series progressed from C70-PCBR1 to C70-PCBR7, the open circuit voltage and the short circuit current gradually increased, followed by a slight drop for C70-PCBR9. An optimal overall power conversion efficiency was observed for C70-PCBR7 with a P3HT : C70-PCBR7 blend ratio of 1 : 0.8 to 1 : 0.9.
Design and simulation of infrared energy harvesting devices (2011)

Despite a recent focus in developing energy harvesting technologies from a variety of sources, no work has been done in capturing blackbody radiation from the surrounding environment. This work aims to extend semiconductor-based solar energy harvesting into the infrared (IR) range of the electromagnetic spectrum so as to take advantage of this blackbody radiation. We have investigated the use of mercury cadmium telluride (HgCdTe) p-n junction devices in order to achieve this goal. A device simulation tool, named MCT-SIM, was developed in order to obtain the photovoltaic characteristics of P+/N-/N+ structures exposed to blackbody radiation and an applied voltage bias. An IR energy harvesting system was developed and evaluated with the use of this tool. When this system is exposed to blackbody radiation at a temperature of 300 K, it generates a series-limited photocurrent of 28.115 mA/cm<sup>2</sup>; this value can be increased through further optimization. Subsequent analysis shows that performance limitations of this system are due to the presence of a large intrinsic carrier concentration and associated Auger effects within the absorbing layer of HgCdTe.
Abstract 3035: Decomposing oncogenic transcriptional signatures to generate maps of divergent cellular states (2017)

Abstract The systematic sequencing of the cancer genome has provided a powerful framework for identifying genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework, and associated experimental and computational methodology, to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. Using this approach, we generated series of RAS/MAPK sub-signatures that reflect known and novel downstream pathways. These sub-signatures were then used to classify KRAS and BRAF mutant cancers into sub groups or cell states, as represented in the novel visual paradigm “OncoGPS map”. OncoGPS approach was first applied to cancers with BRAF mutations. The approach not only accurately classified three groups of BRAF mutant cancers that aligned with sensitivity to BRAF inhibitors, but also identified resistance mechanisms associated with each state, validating the overall approach. OncoGPS also identified four major cell states associated with KRAS mutant cancers. Further characterization of the four cell states showed that multiple molecular features representing epithelial-EMT states and activation of NF-κB pathway delineated two major “axes” of KRAS mutant cancers. In addition to the pathways and cell states defined in each group, the OncoGPS approach is able to identify effective drug combinations which was experimentally tested and confirmed. These results show that the Onco-GPS is an effective analytic framework to explore the complex landscape of oncogenic cellular states across cancers, and a powerful framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms. Citation Format: William J. Kim, William C. Hahn, Jill Mesirov, Pablo Tamayo. Decomposing oncogenic transcriptional signatures to generate maps of divergent cellular states [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3035. doi:10.1158/1538-7445.AM2017-3035
ChemInform Abstract: Enzymatic Synthesis of Kdn Oligosaccharides by a Bacterial α‐(2→6)‐Sialyltransferase. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Environmental and health impact assessment of Liquid Organic Hydrogen Carrier (LOHC) systems – challenges and preliminary results (2015)

This paper presents the first account on the ecotoxicological profile of some potential LOHC structures.
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking (2019)

What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the transition from moderate to compulsive drinking remain poorly understood. We longitudinally tracked the development of compulsive drinking across a binge-drinking experience in male mice. Binge drinking unmasked individual differences, revealing latent traits in alcohol consumption and compulsive drinking despite equal prior exposure to alcohol. Distinct neural activity signatures of cortical neurons projecting to the brainstem before binge drinking predicted the ultimate emergence of compulsivity. Mimicry of activity patterns that predicted drinking phenotypes was sufficient to bidirectionally modulate drinking. Our results provide a mechanistic explanation for individual variance in vulnerability to compulsive alcohol drinking.