gebhart/patrepeval huggingface dataset:
Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors (2023)

Abstract Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient’s tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Paediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This new PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and new treatments development in advanced pediatric malignancies.
Efficacy and Safety of Enteral Recombinant Human Insulin for Reduction of Time-to-Full Enteral Feeding in Preterm Infants: A Randomized, Double-blind, Placebo-Controlled Trial. (2021)

Our trial demonstrated that administration of enteral rh-insulin as supplement to enteral nutrition significantly reduced time to achieve full enteral feeding in preterm infants with a gestational age of 26-33 weeks.
Beam Management for IAB Network in 5G-Advanced Wireless Communication Systems (2021)

This paper proposes a novel beam management (BM) method for integrated access and backhaul (IAB) network. From both specification and commercialization perspectives, it has been spotlighted that IAB network is promising for coverage extension of 5G wireless communication systems at millimeter wave (mmWave) frequency range. In this paper, it is shown that due to the parallelized specification works on 1) BM for access link and 2) resource allocation / topology management for backhaul link, IAB networks can be suffered from high signaling overhead for beam control. The proposed BM method can address the overhead issues (less than 10% signaling overhead is required compared with legacy system in the narrow beam scenarios) by enabling simultaneous update of activated beams across multiple component carriers in IAB networks.
Dynamic memory model based framework for optimization of IP address lookup algorithms (2005)

The design of software-based algorithms for fast IP address lookup targeted for general purpose processors has received tremendous attention in recent years due to its low cost implementation and flexibility. However, all work to date fails to account for the hierarchical memory structure of the processor when designing algorithms. In this work, we propose a dynamic memory model that captures data movement between hierarchical memories and the memory access cost. Using the model, we formulate the design of IP address lookup algorithms as a well-defined optimization problem that minimizes an algorithm's average lookup time. We first show the problem is NP-hard. We then present an optimization framework and associated algorithm based on Lagrange multipliers that terminates in a bounded-error solution. Simulation shows the synthesized algorithm has noticeable performance gain over existing techniques.
In vivo testing of an intra-annular aortic valve annuloplasty ring in a chronic calf model (2012)

In vivo testing of a three-dimensional aortic annuloplasty ring in a chronic calf model proved to be very successful and safe. Using the sizing and implant strategies developed, human trials seem indicated.
<title>Low-temperature approaches for fabrication of high-frequency microscanners</title> (1999)

Within this paper novel applications of low temperature silicon wafer bonding technologies for the fabrication of high frequency silicon microscanners are presented. Two technological approaches are discussed, both using low temperature bonding as a key technological step. Results of the integration of a special low temperature bonding process within the bulk technology approach are shown. Micromirror arrays fabricated with this technology are presented and show promising results for optical applications.
Mechanism of the lithiumiodine exchange in an iodothiophene (2005)

Solutions of 2-lithio-5-methylthiophene (4) were characterized using DNMR techniques and shown to be a mixture of monomer and dimer in THFEt 2 O (3:2). The hypervalent iodine ate complex 5 (Ar 2 I  Li + ), a presumed intermediate in the LiI exchange with 2-iodo-5-methylthiophene, was observed by 13 C and 7 Li NMR spectroscopy at low temperatures (130 °C). At higher temperatures, the ate complex coalesced with 2-lithio-5-methylthiophene. A kinetic scheme was developed, which accounts for the exchange of the monomer 4M, dimer 4D, and 2-iodo-5-methylthiophene (6) with the ate complex 5. The rates of the various exchanges were obtained through a DNMR analysis of the variable temperature 13 C and 7 Li NMR spectra, and the thermodynamic and activation parameters were calculated. The monomer 4M and the ate complex 5 have similar reactivity as aryl donors in the LiI exchange reaction, but 4M is at least 1000 times as reactive as the dimer 4D towards the iodide.Key words: halogenmetal exchange, lithium iodinate, iodine ate complex, lithium reagent, aggregate reactivity.
Abstract IA5: Functional genomics and synthetic lethality (2013)

Abstract Recent advances in genomics now make it possible to consider enumerating all of the genetic lesions in specific cancers. While these approaches will yield critical information regarding the identify, number, and types of alterations found in human tumors, a complementary approach to decipher the molecular basis of malignant transformation depends upon the application of genome scale tools to annotate the function of genes involved in cancer initiation and progression. The integration of such functional approaches with on-going efforts to identify and enumerate genetic alterations in human tumors will provide a path to discover and validate cancer vulnerabilities. Many commonly occurring and well-validated oncogenes and tumor suppressor genes remain refractory to molecularly targeted therapies. We have used systematic loss and gain of function approaches to identify cancer vulnerabilities in the context of oncogenes and tumor suppressor genes. Specifically, we have launched Project Achilles to systematically identify essential genes in more than 500 cancer cell lines that have been characterized genomically. These studies have provided new insights into genes dependent in cancers that express specific oncogenes, loss of genetic elements and in cancers in which particular signaling pathways are activated. Taken together, these studies suggest that combining forward and reverse genetic approaches with information derived from the cancer genome characterization projects provides a path toward a comprehensive understanding of genes involved in cancer. Citation Format: William C. Hahn. Functional genomics and synthetic lethality. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Synthetic Lethal Approaches to Cancer Vulnerabilities; May 17-20, 2013; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(5 Suppl):Abstract nr IA5.
Harmonic Generation in Tissue with Matrix Arrays for 4D Cardiac THI (2019)

Combining 4D echocardiography and tissue harmonic imaging (THI) may improve image quality and consequently diagnosis of heart disease. Beamforming considerations such as methodology for sampling the volume with ultrasound beams, beam shape, and the magnitude of the 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic component generated in tissue are important for 4D cardiac THI. No studies have yet investigated harmonic generation produced by diagnostic matrix arrays for 4D cardiac THI. The objective of the present work is to evaluate harmonic generation in tissue by matrix arrays by considering different 4D beamforming approaches with a numerical model based on the KZK equation. We evaluated the spatial extent, level of the produced 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic component in tissue, and the volume rate of 4D cardiac THI performed by different beamforming approaches. We used different source pressures (applied voltage to the elements) that resulted in peak MI=1.9 in tissue. Beamforming approaches with shallow foci produced the highest peak 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic in tissue (1.2 MPa) yet lowest volume rate (1.7 Hz). Beamforming approaches with deep foci produced the highest 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic at imaging depth of 150 mm (0.3 MPa). The volume rate of 4D cardiac THI performed with focused ultrasound, PWI, and DWI is 1.7-20, 81, and over 1275 Hz, respectively.
Data-driven fault diagnosis in a hybrid electric vehicle regenerative braking system (2012)

Regenerative braking is one of the most promising and environmentally friendly technologies used in electric and hybrid electric vehicles to improve energy efficiency and vehicle stability. In this paper, we discuss a systematic data-driven process for detecting and diagnosing faults in the regenerative braking system of hybrid electric vehicles. The process involves data reduction techniques, exemplified by multi-way partial least squares, multi-way principal component analysis, for implementation in memory-constrained electronic control units and well-known fault classification techniques based on reduced data, such as support vector machines, k-nearest neighbor, partial least squares, principal component analysis and probabilistic neural network, to isolate faults in the braking system. The results demonstrate that highly accurate fault diagnosis is possible with the pattern recognition-based techniques. The process can be employed for fault analysis in a wide variety of systems, ranging from automobiles to buildings to aerospace systems.
Ceramide: A New Approach to Hair Protection and Conditioning. (1994)

Structural lipids may be considered integral components of the human hair fiber. Associated with a proteinaceous matrix, these lipids form the cell membrane complex (CMC), which acts as a cement, ensuring cohesion between the hair (cuticle and cortex) cells. In addition, they provide a barrier to the diffusion process within the hair fiber. We report the results of a study on the vulnerability of these components to physical and chemical insults and illustrate the properties of hair treated with a homolog of a type II ceramide, a synthesized acyl derivative of sphinganine, the N-oleylsphinganine
Magnetic exchange interactions in transition-metal dimers. 14. Binuclear copper(II) Schiff base compounds of salicylaldehyde with aromatic polyamines (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic exchange interactions in transition-metal dimers. 14. Binuclear copper(II) Schiff base compounds of salicylaldehyde with aromatic polyaminesElvira F. Hasty, Lon J. Wilson, and David N. HendricksonCite this: Inorg. Chem. 1978, 17, 7, 1834–1841Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ic50185a028https://doi.org/10.1021/ic50185a028research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multicore Surprises: Lessons Learned from Optimizing Sweep3D on the Cell Broadband Engine (2007)

The Cell Broadband Engine (BE) processor provides the potential to achieve an impressive level of performance for scientific applications. This level of performance can be reached by exploiting several dimensions of parallelism, such as thread-level parallelism using several synergistic processing elements, data streaming parallelism, vector parallelism in the form of 128-bit SIMD operations, and pipeline parallelism by issuing multiple instructions in the same clock cycle. In our exploration to achieve the optimum level of performance for Sweep3D, we have enjoyed many pleasant surprises, such as a very high floating point performance, reaching 64% of the theoretical peak in double precision, and an over all performance speedup ranging from 4.5 times when compared with "heavy iron" processors, up to over 20 times with conventional processors.
Trust based security for cognitive radio networks (2010)

With the rapid increase of wireless applications, Cognitive Radio (CR) has been considered as a promising concept to improve the utilization of limited radio spectrum resources for future wireless communications and mobile computing. Because of the dynamic behavior of Cognitive Radio Networks (CRNs), secure communication in CRNs becomes more critical than for other conventional Wireless networks. So, in this paper we propose a trust-based security solution for CRNs. Trust is calculated from the requesting node depending on various communication attributes and the evaluated trust is compared with the trust threshold value. Depending on the resultant decision, the requested service is available to the requesting user. We prove the security of our proposed scheme in terms of security analysis.
Gold nanoplasmonic particles in tunable porous silicon 3D scaffolds for ultra-low concentration detection by SERS (2021)

A composite material of plasmonic nanoparticles embedded in a scaffold of nano-porous silicon offers unmatched capabilities for use as a SERS substrate. The marriage of these components presents an exclusive combination of tightly focused amplification of Localised Surface Plasmon (LSP) fields inside the material with an extremely high surface-to-volume ratio. This provides favourable conditions for a single molecule or extremely low concentration detection by SERS. In this work the advantage of the composite is demonstrated by SERS detection of Methylene Blue at a concentration as low as a few picomolars. We systematically investigate the plasmonic properties of the material by imaging its morphology, establishing its composition and the effect on the LSP resonance optical spectra.
X129e−XeMolecular Spin Relaxation (2002)

We identify the formation of bound 129Xe-Xe molecules as the primary fundamental spin-relaxation process at densities below 14 amagat. Low pressure Xe relaxation rate measurements as a function of gas composition show that Xe-Xe molecular relaxation contributes 1/T1 = 1/4.1 h to the total observed relaxation rate. The measured rate is consistent with theoretical estimates deduced from previously measured NMR chemical shifts. At atmospheric pressure the molecular relaxation is more than an order of magnitude stronger than binary relaxation. Confusion of molecular and wall relaxation mechanisms has historically caused wall relaxation rates to be overestimated.
Supplementary Figure 3 from <i>miR-152</i> Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer (2023)

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Reconstruction of non-uniformly sampled signal using transposed Farrow structure (2004)

The non-uniform sampling of the signal can be product of an intentional or unintentional process. For example jitter sampling is an unintentional process which is a consequence of time error of sampling circuits. In many DSP applications it is very important to reconstruct the signal from its non-uniformity distributed samples, especially to obtain a uniformly sampled sequence. This paper presents an efficient and accurate technique to obtain an uniform sequence from the non-uniform input. The reconstruction is done by using the transposed Farrow structure. The reconstruction can also be done in a decimating way, reducing the number of samples. The transposed Farrow structure can be designed to satisfy given frequency or time domain requirement according to the application at hand.
Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors (2020)

Two clinical scenarios were identified where FC can be used with confidence for monitoring treatment response to biologics or tofacitinib in patients with UC without the requirement for endoscopy.
Low ICI Symbol Boundary Alignment for 5G Numerology Design (2017)

Symbol boundary alignment, with respect to waveform selection, has an important impact on the numerology design for fifth-generation mobile applications. The current symbol boundary alignment, along with orthogonal frequency division multiplexing (OFDM) waveform, strongly suffers from intercarrier interference (ICI) especially in unmanned aerial vehicles (UAV) communications. This happens when the mobility causes Doppler effect which results in loss of orthogonality in OFDM. The available solutions for overcoming the ICI problem suffer from high complexity, low spectral efficiency, and incompatibility with the current radio access technologies. This paper presents a novel symbol boundary alignment, called Low ICI Symbol (LICIS) boundary alignment numerology, to avoid the disadvantages of the available solutions. LICIS utilizes large subcarrier-spacing to reduce the ICI power (e.g., around 5-dB ICI power reduction with subcarrier spacing of 30 kHz in high-speed UAV communications). Moreover, LICIS is based on the same reference clock as local thermal equilibrium (LTE) which guarantees its compatibility with the current LTE numerology. In addition, this approach places only one guard-interval at the end of a sequence of OFDM symbols and creates a subslot. This leads to less overhead and preserves the spectral efficiency. Furthermore, a pre-fast Fourier transform (FFT) multipath channel equalizer is considered for removing the intersymbol interference between the OFDM symbols occurring within the subslot. Only one additional FFT and IFFT operations are required for the equalizer which creates an acceptable complexity increment compared to the complexity of other available solutions. Numerical and analytical evaluations show the superior performance of the proposed technique in terms of reliability and spectral efficiency
Raman study of strained Ge1−xSnx alloys (2011)

The Ge-Ge longitudinal optical Raman peak has been measured in strained Ge1−xSnx alloy layers grown on top of relaxed InyGa1−yAs buffer layers on GaAs substrates by molecular beam epitaxy. The experimental result shows that the peak frequency shift increases linearly from the value for bulk Ge with the Sn fraction x and the strain ɛ, Δω = ω − ωGe = ax + bɛ. In these experiments alloy and strain contributions are decoupled and measured separately, and a and b are determined to be a = − 82 ± 4 cm−1 and b = − 563 ± 34 cm−1, over the entire composition and strain range investigated.
MHC-I binding affinity derived metrics fail to predict tumor specific neoantigen immunogenicity (2022)

Abstract Tumor-specific antigens emerging through somatic genomic rearrangements, known as neoantigens, play a critical role in current anticancer immunotherapy. They may or may not elicit an immune response when presented on the tumor cell surface bound to the MHC-I molecule, whose strength has been assumed as an indicator of immunogenicity. Several in silico peptide-MHC-I binding affinity predictors are used to prioritize putative immunogenic neoantigens to be experimentally and clinically explored either as biomarkers or targets for anticancer vaccines. This claims for a fair evaluation of such predictors, making essential the development of appropriate databases with experimentally validated, immunogenic/non-immunogenic neoantigens. Thus far, such a database is lacking. We herein present ITSNdb, a new and curated immunogenic neoantigen database and use it to benchmark current neoantigen immunogenicity predictors. Benchmark results failed to support the application of the predicted peptide- MHC-I binding affinity or its derived metrics as a tool to estimate neoantigen immunogenicity and the tumor neoantigen burden as an immunotherapy response biomarker. Moreover, binding affinity based immunogenicity definition leads to identifying wild-type peptide counterparts as predictors of immunotherapy response. We demonstrate that MHC-I binding affinity is insufficient to define neoantigen immunogenicity, despite being necessary for neoantigen tumor cell presentation suggesting that a paradigm shift for the emergence of new rules to identify immunogenic neoantigens is required.
Anal Human Papillomavirus Testing with Digene's Hybrid Capture 2 Using Two Different Sampling Methods (2007)

Anal screening for human papillomavirus-DNA by hybrid capture 2 is a useful method for detection of human papillomavirus-associated disease. Sample collection using Dacron swabs identifies more human papillomavirus-positive patients, and yields higher relative light unit values than using the cervical brush. Further studies are needed to determine the exact value of hybrid capture 2 in the screening for (pre)cancerous lesions of the anal canal.
Preparation of Polystyrene and Surfactant Co-intercalated MoO3 Nano Hybrids and their VOC Gas Sensing Properties (2006)

A new kind of polystyrene and surfactant, didodecyldimethylammonium, co-intercalated MoO3 nano hybrids was prepared by chemical vapor deposition combined with wet process of simple immersion in an organic solution. The hybrid thin films have a characteristic structure of polystyrene and surfactant co-intercalation into MoO3 with b-axis orientation on the LaAlO3 (100) single crystal substrate. The hybrid thin films show a distinct response to acetaldehyde vapor by decreasing the electrical resistance. We discuss the possible sensing mechanism for acetaldehyde gas.