gebhart/patrepeval huggingface dataset:
Clinical and Molecular Features of the Carney Complex: Diagnostic Criteria and Recommendations for Patient Evaluation (2001)

Carney complex is a multiple neoplasia syndrome featuring cardiac, endocrine, cutaneous, and neural tumors, as well as a variety of pigmented lesions of the skin and mucosae. Carney complex is inherited as an autosomal dominant trait and may simultaneously involve multiple endocrine glands, as in the classic multiple endocrine neoplasia syndromes 1 and 2. Carney complex also has some similarities to McCuneAlbright syndrome, a sporadic condition that is also characterized by multiple endocrine and nonendocrine tumors. Carney complex shares skin abnormalities and some nonendocrine tumors with the lentiginoses and certain of the hamartomatoses, particularly Peutz-Jeghers syndrome, with which it shares mucosal lentiginosis and an unusual gonadal tumor, large-cell calcifying Sertoli cell tumor. Careful clinical analysis has enabled positional cloning efforts to identify two chromosomal loci harboring potential candidate genes for Carney complex. Most recently, at the 17q22-24 locus, the tumor suppressor gene PRKAR1A, coding for the type 1alpha regulatory subunit of PKA, was found to be mutated in approximately half of the known Carney complex kindreds. PRKAR1A acts a classic tumor suppressor gene as demonstrated by loss of heterozygosity at the 17q22-24 locus in tumors associated with the complex. The second locus, at chromosome 2p16, to which most (but not all) of the remaining kindreds map, is also involved in the molecular pathogenesis of Carney complex tumors, as demonstrated by multiple genetic changes at this locus, including loss of heterozygosity and copy number gain. Despite the known genetic heterogeneity in the disease, clinical analysis has not detected any corresponding phenotypic differences between patients with PRKAR1A mutations and those without. This article summarizes the clinical manifestations of Carney complex from a worldwide collection of affected patients and also presents revised diagnostic criteria for Carney complex. In light of the recent identification of mutations in the PRKAR1A gene, an estimate of penetrance and recommendations for genetic screening are provided.
Flüssigkeitsmodulierte Mikrowellenablation: in-vitro Experimente (2010)

Ziele: In-vitro Evaluierung verschiedener Flüssigkeiten zur Verstärkung oder zur gezielten Protektion bei der Mikrowellenablation (MWA). Methode: Jeweils 3 Proben 18 verschiedener Flüssigkeiten mit einem Volumen von 20ml wurden mit einem Mikrowellenablationssystem mit einer intern wassergekühlten Nadelantenne für den perkutanen Einsatz in den Leistungsstufen 10, 20, 30, 40 und 45 Watt erhitzt. Die Erhitzung erfolgte bis zu einer Temperatur von 80°C oder einer Dauer von 10 Minuten. Die Temperaturmessung erfolgte alle 10 Sekunden und wurde während des Erhitzungsprozesses und während der Abkühlung bis auf 30°C durchgeführt. Ergebnis: Am schnellsten ließ sich Gastrografin (370s), gefolgt von Magnograf (410s) und HES 10% (420s) auf 80°C erhitzen. Die am schlechtesten zu erhitzende Flüssigkeit war Lipiodol (10min-54,5±2,43°C), gefolgt von Aqua dest. (10min –56±2,42°C) und Glukose 5% (10min –56,6±1,69°C). Schlecht erhitzbare Flüssigkeiten wie die Glukoselösungen, Lipiodol oder Aqua dest wiesen eine geringe Steigung der Temperaturkurve in Abhängigkeit der verwendeten Leistungsstufe auf (m=0,60–0,73), wohingegen gut zu erhitzende Flüssigkeiten, wie die Natriumchlorid-Lösungen, Ringer- und HES-Lösungen und die Kontrastmittel Gastrografin, Gadovist und Magnograf eine bis zu doppelt große Steigung der Temperaturkurve aufwiesen (m=0,99 –1,20). Die Steigung der Temperaturkurven korreliert stark positiv mit der maximal erreichten Temperatur bei 45 Watt Leistung (Pearson-Korrelationskoeffizient: 0,97). Schlussfolgerung: Durch die zusätzliche Applikation einer geeigneten Flüssigkeit lassen sich verstärkende oder protektive Effekte bei der MWA erzielen. Zur Verstärkung sind besonders Gastrografin, Gadovist, Magnograf und 10%-HES geeignet, wohingegen sich eine Protektion besonders durch den Einsatz von Aqua dest, Lipiodol und 5%-Glukoselösung erzielen lässt.
Large-Signal Network Analysis for Over-the-Air Test of Up-Converting and Down-Converting Phased Arrays (2019)

We explore large-signal network analysis for the over-the-air test of up-converting and down-converting phased arrays. The approach first uses a vector network analyzer to characterize a three-dimensional test environment at RF. The vector network analyzer is then power- and phase-calibrated for the characterization of up-converting and down-converting phased arrays with an IF input or output. We illustrate the approach with measurements of a down-converting phased array.
Supplementary Figure 3 from Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues (2023)

&lt;p&gt;Figure S3. T serves as a co-substrate of 5α-reductase but does not considerably alter the kinetics of AD metabolism in primary prostate tissues under mixed substrate conditions.&lt;/p&gt;
A Transcriptomic Severity Metric that Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients (2021)

Purpose Prognostic metrics for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking. Here, we evaluated a whole blood, multiplex host mRNA expression metric, Inflammatix-Severity-2 (IMX-SEV-2), for identifying septic, hospitalized patients for 30-day mortality, development of chronic critical illness (CCI), discharge disposition, and/or secondary infections. Methods This is a retrospective, validation cohort analysis of a prospectively enrolled 335 patient study with surgical sepsis treated in the surgical intensive care unit. Whole blood collected in PAXgene ® Blood RNA collection tubes at 24 hours post sepsis diagnosis was analyzed using a custom 29-mRNA classifier (IMX-SEV-2) in a CLIA-CAP-accredited diagnostic laboratory using the NanoString FLEX ® profiler. Results Among patients meeting Sepsis-3 criteria, the IMX-SEV-2 severity score was significantly better (p&lt;0.05) at predicting secondary infections (AUROC 0.71) and adverse clinical outcomes (AUROC 0.75) than C-reactive protein (CRP), absolute lymphocyte counts (ALC), total white blood cell (WBC) count, age and Charlson comorbidity index (and better, albeit nonsignificantly, than IL-6 and APACHE II). Using multivariate logistic regression analysis, only combining the Charlson comorbidity index (AUROC 0.80) or APACHE II (AUROC 0.81) with the IMX-SEV-2 significantly improved prediction of adverse clinical outcomes, and combining with the Charlson comorbidity index for predicting 30-day mortality (AUROC 0.79). Conclusions The IMX-SEV-2 severity score was superior at predicting secondary infections and overall adverse clinical outcomes versus other common metrics. Importantly, combining a rapidly measured transcriptomic metric with clinical or physiologic indices has sufficient precision to optimize resource utilization and allow adjustments to patient management that may improve outcomes in surgical sepsis. Hospitalized patients who are septic and present with an elevated IMX-SEV2 severity score and pre-existing comorbidities would be strong candidates for clinical interventions aimed at reducing the risk of secondary infections and adverse clinical outcomes.
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1 (2011)

Aberrant DNA methylation is often associated with cancer and the formation of tumors; however, the underlying mechanisms, in particular the recruitment and regulation of DNA methyltransferases remain largely unknown. In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in vivo. Dnmt1 and USP7 formed a soluble dimer complex that associated with UHRF1 as a trimeric complex on chromatin. Complex interactions were mediated by the C-terminal domain of USP7 with the TS-domain of Dnmt1, whereas the TRAF-domain of USP7 bound to the SRA-domain of UHRF1. USP7 was capable of targeting UHRF1 for deubiquitination and affects UHRF1 protein stability in vivo. Furthermore, Dnmt1, UHRF1 and USP7 co-localized on silenced, methylated genes in vivo. Strikingly, when analyzing the impact of UHRF1 and USP7 on Dnmt1-dependent DNA methylation, we found that USP7 stimulated both the maintenance and de novo DNA methylation activity of Dnmt1 in vitro. Therefore, we propose a dual role of USP7, regulating the protein turnover of UHRF1 and stimulating the enzymatic activity of Dnmt1 in vitro and in vivo.
Surface Orientation From Two Camera Stereo With Polarizers (1990)

We present a simple method for determining the 3-D orientation of a flat surface from the specular reflection of light, exploiting the polarizing properties of materials. Existing methods which compute surface orientation from specular reflection are purely intensity based and need to rely upon precise knowledge of how specularly reflecting light rays are initially incident upon the material surface. These methods require elaborate structured lighting environments which involve much preliminary calibration. The method presented here computes surface orientation independent of any a priori knowledge of the geometry of specular reflection, as long as specular reflection occurs into the camera sensor from points of interest at which orientation is to be constrained. This obviates the need for any structured lighting. By observing how the transmitted intensity of specularly reflected light through a polarizing filter is varied by rotating the filter, one can determine the specular plane of incidence in which the path of specular reflection must lie. Under the assumption that the surface normal is contained in the specular plane of incidence, a determination of two nonparallel specular planes of incidence from a stereo pair of cameras yields a computation of the surface normal from their planar intersection. For flat surfaces the correspondence of points between the stereo pair of cameras need not be precise, only that the intersecting specular planes of incidence correspond to two points that lie on the same flat surface, or on two flat surfaces with equivalent orientation. This is a much weaker correspondence requirement than for conventional parallax stereo.
Eye of the Needle. (2021)

A retired patient visits our author, who is professor of ophthalmology and neuroscience at Johns Hopkins University School of Medicine, to find out why he is suddenly struggling with his vision and learn why but a single treatment option exists for macular degeneration, a condition that affects 200-million people worldwide.
Alzheimerâ€™s disease causation by copper toxicity and treatment with zinc (2014)

Evidence will be presented that the Alzheimer's disease (AD) epidemic is new, the disease being very rare in the 1900s. The incidence is increasing rapidly, but only in developed countries. We postulate that the new emerging environmental factor partially causal of the AD epidemic is ingestion of inorganic copper from drinking water and taking supplement pills, along with a high fat diet. Inorganic copper can be partially directly absorbed and elevate the serum free copper pool. The Squitti group has shown that serum free copper is elevated in AD, correlates with cognition, and predicts cognition loss. Thus, our inorganic copper hypothesis fits well with the Squitti group data. We have also shown that AD patients are zinc deficient compared to age-matched controls. Because zinc is a neuronal protective factor, we postulate that zinc deficiency may also be partially causative of AD. We carried out a small 6 month double blind study of a new zinc formulation and found that in patients age 70 and over, it protected against cognition loss. Zinc therapy also significantly reduced serum free copper in AD patients, so efficacy may come from restoring normal zinc levels, or from lowering serum free copper, or from both.
Effect of carrier lifetime on forward-biased silicon Mach-Zehnder modulators (2008)

We present a systematic study of Mach-Zehnder silicon optical modulators based on carrier-injection. Detailed comparisons between modeling and measurement results are made with good agreement obtained for both DC and AC characteristics. A figure of merit, static VpiL, as low as 0.24Vmm is achieved. The effect of carrier lifetime variation with doping concentration is explored and found to be important for the modulator characteristics.
Doppler Sonographic Findings in an Experimental Rabbit Model of Necrotizing Enterocolitis (2010)

The NEC+ group showed a significant increase in the PSV and RI during the 1- to 2-hour period.
Optimisation of a stereo image analysis by densify the disparity map based on a deep learning stereo matching framework (2022)

Stereo vision is used in many application areas, such as robot-assisted manufacturing processes. Recently, many different efficient stereo matching algorithms based on deep learning have been developed to solve the limitations of traditional correspondence point analysis, among others. The challenges include texture-poor objects or non-cooperative objects. One of these end-to-end learning algorithms is the Adaptive Aggregation Network (AANet/AANet+), which is divided into five steps: feature extraction, cost volume construction, cost aggregation, disparity computation and disparity refinement. By combining different components, it is easy to create an individual stereo matching model. Our goal is to develop efficient learning methods for robot-assisted manufacturing processes for cross-domain data streams. The aim is to improve recognition tasks and process optimisation. To achieve this, we have investigated the AANet+ in terms of usability and efficiency on our own test-dataset with different measurement setups (passive stereo system). Input of the AANet+ are rectified stereo pairs of the test-dataset and a pre-trained model. Instead of generating our own training dataset, we used two pre-trained models based on the KITTI-2015 and SceneFlow datasets. Our research has shown that the pretrained model based on the Scene Flow dataset predicts disparities with better object delimination. Due to the Out-of-Distribution inputs, only reliable disparity predictions of the AANet are possible for test data sets with parallel measurement setup. We compared the results with two traditional stereo matching algorithms (SemiGlobal block matching and DAISY). Compared to the traditionally computed disparity maps, the AANet+ is able to robustly detect texture-poor objects and optically non-cooperative objects.
Comparative Investigation on Different Topologies of Integrated Magnetic Structures for Current-doubler Rectifier (2007)

The advancement of technology requires that power supplies have high efficiency and high power density. The current doubler rectifier has been presented as a solution to decrease the transformer secondary power loss and increase the power efficiency. In this paper, the unified equivalent coupled inductor circuit models are constructed for different current doubler rectifier integrated magnetic structures. Based on the finite element method analysis, the impedance matrixes and coupling coefficient matrixes of different structures are compared. The efficiency and performance of different structures are also experimentally studied.
A neuro-stimulus chip with telemetry unit for retinal prosthetic device (2000)

In this retinal prosthesis project, a rehabilitative device is designed to replace the functionality of defective photoreceptors in patients suffering from retinitis pigmentosa (RP) and age-related macular degeneration (AMD). The device consists of an extraocular and an intraocular unit. The implantable component receives power and a data signal via a telemetric inductive link between the two units. The extraocular unit includes a video camera and video processing board, a telemetry protocol encoder chip, and an RF amplifier and primary coil. The intraocular unit consists of a secondary coil, a rectifier and regulator, a retinal chip with a telemetry protocol decoder, a stimulus signal generator, and an electrode array. This paper focuses on the design, fabrication, and testing of a microchip which serves as the telemetry protocol decoder and stimulus signal generator. It is fabricated by MOSIS with 1.2-mm CMOS technology and was demonstrated to provide the desired biphasic current stimulus pulses for an array of 100 retinal electrodes at video frame rates.
Sputter etching in an argon–oxygen plasma and its implications to device fabrication (1979)

The presence of oxygen in a sputter etching (SPE) plasma can have both beneficial and detrimental effects. An argon–oxygen plasma can create conditions which are particularly favorable for the fabrication of magnetic bubble devices. The effects of oxygen in a conventional diode rf SPE system on etch rates and on the magnetic properties of unmasked permalloy (NiFe) films are discussed. In particular, it is shown that the etch rate of NiFe relative to Au is suppressed and that the increase in coercivity of the NiFe caused by SPE is minimized when oxygen is introduced in the plasma. Application of these findings is made to bubble domain device fabrication. Conversely, the presence of unwanted oxygen can have a detrimental effect on pattern profiles when an organic resist mask is used and can generally lead to irreproducible etch rates. Ways to minimize these undesired effects are discussed.
N-benzyl-N-methyldecan-1-amine, a phenylamine derivative isolated from garlic cloves, induces G2/M phase arrest and apoptosis in U937 human leukemia cells (2014)

Epidemiological studies indicate that components of garlic (Allium sativum) have anti-proliferative effects against various types of cancer. In the present study, we investigated the effect of newly isolated phenylamine derivative N-benzyl-N-methyldecan-1-amine (NBNMA) from garlic cloves on the inhibition of the growth and apoptosis of human leukemia U937 cells and its potential anticancer mechanism. NBNMA exhibited an antiproliferative effect in U937 cells by inducing cell cycle arrest at the G2/M phase and apoptotic cell death. Western blot analyses revealed that NBNMA decreased the expression of the regulator genes of G2/M phase progression, cyclin dependent kinase (Cdk) 2 and Cdc2 and elevated the expression of the Cdk inhibitor p21WAF1/CIP1 in a p53-independent manner. In addition, NBNMA activated caspase-8 and caspase-9, initiator caspases of the extrinsic and intrinsic pathways of apoptosis, respectively, which led to activation of executioner caspase-3 along with degradation of poly(ADP-ribose) polymerase. NBNMA-induced apoptosis was observed in parallel with an increased ratio of pro-apoptotic Bax and Bad/anti-apoptotic Bcl-2 and Bcl-xL, and inhibition of inhibitor of apoptosis protein (IAP) family members XIAP and cIAP-1. Furthermore, NBNMA-treated cells displayed enhanced release of cytochrome c from the mitochondria into the cytosol concomitant with a loss of mitochondrial membrane potential and downregulation of Bid, suggesting that NBNMA-induced apoptosis occurred via the extrinsic and intrinsic apoptotic pathways with a possible link to Bid protein activity between the two pathways. These results indicate that NBNMA has promising potential to become a novel anticancer agent for the treatment of leukemia. We provide new insight into the mechanisms underlying the anticancer effect of NBNMA.
Geometric Computational Mechanics and Optimal Control (2011)

Abstract : The research performed during this AFOSR grant has extended the basic discrete DMOC (Discrete Mechanics and Optimal Control) framework to derive algorithms for general nonholonomic multi-body systems, with applications to a variety of problems including space mission design. A computational framework was developed which can automatically construct integration and optimization schemes by providing a high-level description of the mechanical system in terms of its physical layout, inertial properties, constraints, actuation, and external influences. This last year of the grant was focused on optimization problems with non-holonomic constraints as well as continued applications to space mission design. Besides describing the latest results and publications obtained over the past 12 months, we also describe the next steps that we expect to explore now that the work of this grant is over.
Time‐dependent diffusion tensor imaging and diffusion modeling of age‐related differences in the medial gastrocnemius and feasibility study of correlations to histopathology (2023)

The age-related patterns in λ<sub>2</sub> (t) and λ<sub>3</sub> (t) could tentatively be explained from RPBM fits; these patterns may potentially arise from a decrease in fiber asymmetry and an increase in permeability with age.
ECONOMIC FEASIBILITY ANALYSIS OF HYDROGEN PRODUCTION BY INTEGRATED CERAMIC MEMBRANE SYSTEM (2002)

Praxair has completed a technoeconomic feasibility analysis of a small scale hydrogen produc-tion system based on oxygen transport membrane (OTM) and hydrogen transport membrane (HTM). This system has a potential to significantly reduce the cost of hydrogen for use in the transportation sector for fuel-cell vehicle fueling stations and in the industrial sector as a small, on-site hydrogen supply. This paper updates the results obtained from an economic feasibility evaluation, as well as the future plan for the HTM development.
Demonstration of a pallido‐nigral projection innervating dopaminergic neurons (1975)

Abstract Afferents to the substantia nigra from the neostriatum and globus pallidus were studied in the rat by means of the autoradiographic tracing technique. 3 H‐leucine was injected stereotaxically into either the globus pallidus or neostriatum. Twenty‐four hours later the axoplasmic transport of labelled proteins to the substantia nigra was studied by light and electron microscopic autoradiography. In animals used for electron microscopy, degeneration of dopaminergic cells in the substantia nigra was induced by intraventricular injection of 6‐hydroxydopamine 72 hours before sacrifice. After neostriatal injections, light microscopic analysis revealed heavy labelling of the globus pallidus and entopeduncular nucleus, but only background labelling of the subthalamic nucleus. There was preferential labelling of the zona reticulata of the substantia nigra, with significantly less labelling of the zona compacta. After pallidal injections, light microscopic analysis showed very light labelling of those parts of the caudate‐putamen in the vicinity of the injection site. There was intense labelling of the subthalamic nucleus and heavy labelling of the entopeduncular nucleus. The zona compacta of the substantia nigra was also heavily labelled. There was considerably less labelling of the zona reticulata. The electron microscopic analyses showed that after neostriatal injections, autoradiographic grains in the substantia nigra were located preferentially over boutons which terminated on normal dendritic processes. After pallidal injections, however, grains were preferentially located over boutons synapsing with degenerating dendritic processes. The degeneration produced in these dopaminergic processes by 6‐hydroxydopamine was invariably of the dark type. Except for the different association with degenerating vs. non‐degenerating dendrites, the subcellular distribution of autoradiographic grains in the substantia nigra was the same after injection into either the globus pallidus or caudate‐putamen. Approximately 80 percent of the grains were over axons or boutons which invariably made symmetrical synaptic contacts. These observations demonstrate the existence of a pallido‐nigral projection which terminates preferentially on dopaminergic cells in the pars compacta of the substantia nigra. They also confirm previous studies indicating that the strionigral projection terminates mainly in the pars reticulata. These terminations appear to be principally to non‐dopaminergic cells.