gebhart/patrepeval huggingface dataset:
Notch and Cdk5 in Zebrafish mindbomb Mutant: Co-regulation or Coincidence? (2018)

Notch signalling is critical for the development of the nervous system. In the zebrafish mindbomb mutants, disruption of E3 ubiquitin ligase activity inhibits Notch signalling. In these mutant embryos, precocious development of primary neurons leading to depletion of neural progenitor cells results in a neurogenic phenotype characterized by defects in neural patterning and brain development. Cyclin-dependent kinase 5 (Cdk5), a predominant neuronal kinase, is involved in a variety of essential functions of the nervous system. Most recently, mammalian studies on Notch and Cdk5 regulating each other's function have been emerging. The status of Cdk5 in the mindbomb mutant embryos with excessive primary neurons is not known. In situ hybridization of the zebrafish mindbomb mutant embryos uncovered a robust upregulation in Cdk5 expression but with a reduced Cdk5 activity. The implications of these findings in both the mammalian system and zebrafish are discussed in this mini-review to provide a glimpse into the relationship between Notch and Cdk5 that may explain certain neurodevelopmental defects associated with either mutations in ubiquitin ligase or altered expression of Cdk5.
In-plane switching dual-frequency liquid crystal cell (2007)

The electro-optical responses of the in-plane switching (IPS) dual-frequency liquid crystal (LC) cell operated with the amplitude-modulation method and the frequency-modulation method were investigated. The obtained results reveal that the electric torque exerted to the LCs and the strong anchoring energy produced from the rubbed polyimide dominate the reorientation of the LCs. With the frequency-modulation method, the generated electric torque combined with the strong surface anchoring energy give the cell a very short fall time, which is independent of the applied frequency. A new waveform composed of the amplitude modulation and the frequency modulation of the supplied voltage-pulse to achieve a fast responding IPS LC cell is proposed. The obtained response time is much less than that of the conventional amplitude-modulation method.
Development of a Single Detector Ring Micro Crystal Element Scanner: QuickPET II (2005)

This article describes a single ring version of the micro crystal element scanner (MiCES) and investigation of its spatial resolution imaging characteristics for mouse positron emission tomography (PET) imaging. This single ring version of the MiCES system, referred to as QuickPET II, consists of 18 MiCE detector modules mounted as a single ring in a vertical gantry. The system has a 5.76-cm transverse field of view and a 1.98-cm axial field of view. In addition to the scanner and data acquisition system, we have developed an iterative reconstruction that includes a model of the system's detector response function. Evaluation images of line sources and mice have been acquired. Using filtered backprojection, the resolution for a reconstructed line source has been measured at 1.2 mm full width at half maximum. F-18-2-fluoro-2-deoxyglucose mouse PET images are provided. The result shows that QuickPET II has the imaging characteristics to support high-resolution, static mouse PET studies using 18-F labeled compounds.
Kinetics and mechanism for the photolysis of nitrogen dioxide in air (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism for the photolysis of nitrogen dioxide in airD. H. Stedman and H. NikiCite this: J. Phys. Chem. 1973, 77, 22, 2604–2609Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/j100640a005https://doi.org/10.1021/j100640a005research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Search for higgsino pair production in pp collisions at $\\sqrt{s}$ = 13 TeV in final states with large missing transverse momentum and two Higgs bosons decaying via $\\mathrm{H} \\to\\mathrm{b}\\overline{\\mathrm{b}}$ (2017)

Results are reported from a search for new physics in 13 TeV proton-proton collisions in the final state with large missing transverse momentum and two Higgs bosons decaying via $\\mathrm{H} \\to\\mathrm{b}\\overline{\\mathrm{b}}$. The search uses a data sample accumulated by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb$^{-1}$. The search is motivated by models based on gauge-mediated supersymmetry breaking, which predict the electroweak production of a pair of higgsinos, each of which can decay via a cascade process to a Higgs boson and an undetected lightest supersymmetric particle. The observed event yields in the signal regions are consistent with the standard model background expectation obtained from control regions in data. Higgsinos in the mass range 230-770 GeV are excluded at 95% confidence level in the context of a simplified model for the production and decay of approximately degenerate higgsinos.
Incremental Enhancement of SEU Hardened 90 nm CMOS Memory Cell (2011)

SEU enhancements were introduced into a radiation hardened 90 nm CMOS technology to achieve upset immunity. An incremental enhancement approach that enables various SEU/performance trade-off was demonstrated on the same basic SRAM cell to achieve various degrees of hardness, by the selective utilization of enhancement features. Single event upset testing, as well as MRED simulation, have demonstrated a significant enhancements achieved with a minimal performance penalty.
Resistive Switching Characteristics in MnO Nanoparticle Assembly and Ag2Se Thin Film Devices (2017)

Ligand-capped monodisperse manganese oxide nanoparticles were chemically synthesized via thermal decomposition. A close-packed nanoparticle monolayer was formed on a Au bottom electrode via dip-coating and annealing. As2Se/MnO heterostructures with a Ag top electrode and a Au bottom electrode were fabricated. The Ag/Ag2Se/MnO/Au devices presented stable bipolar resistive switching behaviors, with low voltage operation (-0.5/+0.8 V) and good endurance and retention properties. The bipolar resistive switching characteristics were attributed to the formation of conductive filaments in the Ag2Se/MnO bilayers. The conduction mechanisms were explained by the ohmic conduction, Schottky emission, and space-charge-limited conduction (SCLC) mechanisms for the low resistance state and high resistance state, respectively.
Three dimensional microfluidic design with spincoated micrometer-thin elastomer multilayer (2012)

We propose a method to fabricate three dimensional microfluidic channel systems with spincoated micrometer-thin elastomer multilayer. We use the molecular diffusion of thin elastomer layers to our advantage and propose a microfluidic fabrication process free of molding and bonding steps. We achieved various expandable three dimensional multilayer channel designs that can have interesting applications.
Porous Fe/CeO2 Nanozyme-Based Hydrogel Colorimetric Platform for on-Site Detection of Kanamycin (2023)

Excessive use of antibiotics causes their residues in the environment and food, seriously threatening ecosystem and human health. Designing a portable and sensitive sensor for on-site analysis of antibiotics is therefore in high demand. In this study, we have developed a smartphone-capable hydrogel colorimetric platform for ultrasensitive detection of kanamycin (KAN) based on aptamer-regulated nanozyme activity. The synthesized Fe/CeO2 hexagonal bipyramidal microcrystals (Fe/CeO2 HBs) exhibited excellent peroxidase-like activity, but it could be obviously inhibited by the aptamer, and the inhibition effect was further enhanced with the specific recognition between target and aptamer, making it possible to design a facile colorimetric method for KAN analysis. Moreover, the aptamer-functionalized Fe/CeO2 HBs (Fe/CeO2 HBs@Apt) were introduced into the hydrogel to fabricate a portable analytical tube, whose colorimetric signal was read out by a smartphone platform, realizing the on-site analysis of KAN. The linear response range was 0.05–48.45 ng mL–1 with an ultralow detection limit of 0.035 ng mL–1 and the recovery rate ranging from 99.57 to 103.76% for spiked real samples, demonstrating its superior accuracy and reliability. This work provides new insights into designing the solid-phase hydrogel-based colorimetric method for on-site analysis of antibiotic residues.
In‐Situ Switching from Barrier‐Limited to Ohmic Anodes for Efficient Organic Optoelectronics (2014)

Injection and extraction of charges through ohmic contacts are required for efficient operation of semiconductor devices. Treatment using polar non‐solvents switches polar anode surfaces, including PEDOT:PSS and ITO, from barrier‐limited hole injection and extraction to ohmic behaviour. This is caused by an in‐situ modification of the anode surface that is buried under a layer of organic semiconductor. The exposure to methanol removes polar hydroxyl groups from the buried anode interface, and permanently increases the work function by 0.2–0.3 eV. In the case of ITO/PEDOT:PSS/PBDTTT‐CT:PC71BM/Al photovoltaic devices, the higher work function promotes charge transfer, leading to p‐doping of the organic semiconductor at the interface. This results in a two‐fold increase in hole extraction rates which raises both the fill factor and the open‐circuit voltage, leading to high power conversion efficiency of 7.4%. In ITO/PEDOT:PSS/F8BT/Al polymer light‐emitting diodes, where the organic semiconductor's HOMO level lies deeper than the anode Fermi level, the increased work function enhances hole injection efficiency and luminance intensity by 3 orders of magnitude. In particular, hole injection rates from PEDOT:PSS anodes are equivalent to those achievable using MoO 3 . These findings exemplify the importance of work function control as a tool for improved electrode design, and open new routes to device interfacial optimization using facile solvent processing techniques. Such simple, persistent, treatments pave the way towards low cost manufacturing of efficient organic optoelectronic devices.
Tandem and Triple-Junction Polymer:Nanocrystal Hybrid Solar Cells Consisting of Identical Subcells (2014)

Tandem and triple-junction polymer:nanocrystal hybrid solar cells with identical subcells based on P3HT:CdSe nanocrystal bulk heterojunctions (BHJs) are reported for the first time showing 2-fold and 3-fold increases of open-circuit voltage (VOC), respectively, relative to the single-junction cell. A combination of nanocrystalline ZnO and pH-neutral PEDOT:PSS is used as the interconnecting layer, and the thicknesses of subcells are optimized with the guidance of optical simulations. As a result, the average power conversion efficiency (PCE) exhibits a significant increase from 2.0% (VOC = 0.57 V) in single-junction devices to 2.7% (champion 3.1%, VOC = 1.28 V) in tandem devices and 2.3% (VOC = 1.98 V) in triple-junction devices.
Antileukemia Activity of JNJ-26481585, a Potent Second-Generation Histone Deacetylase Inhibitor (2008)

Abstract Background: Histone Deacetylases (HDACs) play key roles in tumor cell proliferation, survival and angiogenesis. HDAC inhibitors have been shown to induce cell cycle arrest, terminal differentiation and/or apoptosis in broad spectrum of human tumors and xenograft animal models. JNJ-26481585 is a hydroxamic acid derivative second-generation pan-HDAC inhibitor with nM potency in pre-clinical studies. In animal models, no evidence of cardiac toxicity has been observed, which suggests a better therapeutic index than other HDAC inhibitors. Aim: We evaluated the anti-leukemia and molecular activity of JNJ-26481585 in human leukemia cell lines (HL60, MOLT4, THP1 and U937) and primary leukemia cells. Results: JNJ-26481585 potently inhibited proliferation of leukemia cells, with IC50 between 25 nM and 250 nM after 24-hour of treatment. In contrast, analysis of other HDAC inhibitors, including vorinostat and MGCD0103, had IC50 in the μM range. JNJ-26481585 also induced dose-dependent apoptosis (aprox. 25–35% at concentration of 25 nM) of leukemia cell lines by Annexin V staining after 24-hour treatment. A synergistic apoptotic effect was observed by co-treating with hypomethylating agent 5-aza-2′-deoxycytidine (25% with JNJ-26481585 25 nM, 5% with decitabine 1 μM, and 70% for the combination). Acetylation of histones H3, H4 and phosphorylation of H2AX was also observed after exposure to JNJ-26481585 at concentration of 12.5 nM or higher. We also studied fresh primary leukemia cells from 9 patients (ALL N=1, MDS N=1, AML N=7). Six of the 9 patients (67%) had relapsed/refractory disease. Their median white cell counts were 32×103/L (range 6–407×103/L), with 25% to 95% blasts in the peripheral blood. Treatment with JNJ-26481585 for 24-hours induced significant growth arrest and apoptosis (20–50% apoptosis at 25 nM) in a dose-dependent manner (between 12.5–500 nM), but not in mononuclear cells from healthy donors (N=2). It also induced acetylation of histones H3, H4, phosphorylation of H2AX, induction of p21 and HSP70, activation of caspase-3, cleavage of PARP in these primary leukemia cells after 24-hour treatment at concentrations of 12.5–500 nM. Conclusion: JNJ-26481585 is a potent second generation pan-HDAC inhibitor with activity in human leukemias. It is a promising new agent for future clinical studies either as single agent or combination epigenetic therapy with DNA hypomethylating agents and should be tested in clinical trials.
Oxygen uptake and carbohydrate metabolism by in vitro derived bovine embryos (1996)

The consumption of oxygen, uptake of pyruvate and glucose and production of lactate were determined for groups of bovine embryos produced in vitro from the one-cell to the blastocyst stage (day 0-6 of culture). Measurements were made in Hepes-buffered synthetic oviduct fluid medium supplemented with 1.0 mmol pyruvate l-1, 10 mmol D,L-lactate l-1 and 1.5 mmol glucose l-1 and also 3 mg BSA ml-1 and, from day 5 of development, 10% (v/v) fetal calf serum. The amount of ATP production was determined from oxygen consumption and the proportion of glucose taken up that could be accounted for by lactate production. The data revealed that oxygen consumption was relatively constant from days 0-4 of culture (0.24-0.27 nl per embryo h-1), but increased with the initiation of compaction (0.39 nl per embryo h-1) and continued to increase with the formation and expansion of the blastocoel (0.9 nl per embryo h-1). Both pyruvate and glucose uptake followed similar patterns. Furthermore, when plotted against oxygen consumption, both pyruvate and glucose uptake increased significantly (P < 0.001) in a linear relationship (R2 = 0.61 and 0.49, respectively). Lactate production also increased with development and accounted for 40% of glucose uptake at day 0 of culture (putative zygotes), increasing to 70% by day 2 (eight-cell stage) and 100% of glucose uptake from day 4 of culture onwards. ATP production followed a similar pattern to that of oxygen consumption (60-85 pmol per embryo h-1 from day 0 to day 4) increasing with compaction (124 pmol per embryo h-1) and blastulation (221 pmol per embryo h-1). For precompaction stages, 93-96% of ATP production was derived from oxidative phosphorylation, decreasing to 82% with compaction. ATP produced by oxidative phosphorylation could be accounted for by the uptake of pyruvate, suggesting that bovine embryos produced in vitro utilize little endogenous substrates when appropriate exogenous substrates are present in the culture medium. The data revealed that bovine embryos were dependent on oxidative phosphorylation for energy (ATP) production at all stages of pre-elongation development, with perhaps a shift in dependence towards glycolysis in conjunction with compaction. It follows that oxidizable substrates, such as pyruvate and certain amino acids, are preferred in embryo culture medium during development in vitro.
Amblyopic Suppression: Passive Attenuation, Enhanced Dichoptic Masking by the Fellow Eye or Reduced Dichoptic Masking by the Amblyopic Eye? (2018)

We conclude that the reduced dichoptic masking by the amblyopic eye, within the context of normally balanced interocular inhibition, produces the amblyopic suppression at mid to low frequencies.
Compartments, Connectivity & Baffling Analyzed by the Extent of Equilibration of Asphaltene Gradients Using DFA (2016)

This paper describes how the combination of Downhole Fluid Analysis (DFA) optical density for measuring asphaltene gradients combined with Flory-Huggins-Zuo (FHZ) EoS thermodynamic analysis is the method of choice to identify (in real time) three major field economical risks: compartments, connectivity and baffling. A deepwater field example from exploration/appraisal phase to development phase is reviewed. In this particular case, and for the first time within one field, DFA oil color measurements reveal initial or preserved charges, equilibrated charges and an intermediate state (monotonic gradient of asphaltenes but in disequilibrium). When part of the field is equilibrated and another part not equilibrated, the implication is that baffling impedes equilibration and production; both expectations are confirmed herein. Production data confirms that the region of the reservoir with equilibrated asphaltenes had much better production rates than the region with asphaltenes in disequilibrium. Moreover, the baffles are found to be associated with deformation banding seen in core and borehole image log. In addition, the improved understanding on controls over production rates helps to project wellbore results away from wellbore. The paper describes the detailed workflow using DFA asphaltene measurements and the FHZ EoS to successfully address many key reservoir properties at early and all stages of reservoir exploration and production.
Implant‐Related Complications: Relevant Anatomy and an Approach for Prevention (2012)

Pacemaker and implantable cardioverter-defibrillator (ICD) implantations have been associated with multiple potential complications. Especially concerning complications include cardiac perforation, pneumothorax, cardiovascular implantable electronic device infections, thromboembolism, and bleeding. Many pacemaker and ICD complications can be reduced by careful attention to implantation technique.
ecursive Computation and Real-Time rallel Architectures: A Framework (1995)

Abstract-The time-recursive computation has been proven a particularly useful tool in real-time data compression, in trans-form domain adaptive filtering, and in spectrum analysis. Unlike the FFT-based ones, the time-recursive architectures require only local communication. Also, they are modular and regular, thus they are very appropriate for VLSI implementation and they allow a high degree of parallelism. In this two-part paper, we establish an architectural framework for parallel time-recursive computation. We clonsider a class of linear operators that consists of the discrete time, time invariant, compactly supported, but otherwise arbitrary kernel functions. We show that the structure of the realization of a given linear operator is dictated by the decomposition of the latter with respect to proper basis functions. An optimal way for carrying out this decomposition is demonstrated. The parametric forms of the basis functions are identified and their properties pertinent to the architecture design are studied. A library of architectural building modules capable of realizing these functions is developed. An analysis of the implementatioin complexity for the aforementioned modules is conducted. Based on this framework, the time-recursive archi-tecture of a given hear operator can be derived in a systematic routine way. I.
Electrostatic analysis of n-doped SrTiO3 metal-insulator-semiconductor systems (2015)

Electron doped SrTiO3, a complex-oxide semiconductor, possesses novel electronic properties due to its strong temperature and electric-field dependent permittivity. Due to the high permittivity, metal/n-SrTiO3 systems show reasonably strong rectification even when SrTiO3 is degenerately doped. Our experiments show that the insertion of a sub nanometer layer of AlOx in between the metal and n-SrTiO3 interface leads to a dramatic reduction of the Schottky barrier height (from around 0.90 V to 0.25 V). This reduces the interface resistivity by 4 orders of magnitude. The derived electrostatic analysis of the metal-insulator-semiconductor (n-SrTiO3) system is consistent with this trend. When compared with a Si based MIS system, the change is much larger and mainly governed by the high permittivity of SrTiO3. The non-linear permittivity of n-SrTiO3 leads to unconventional properties such as a temperature dependent surface potential non-existent for semiconductors with linear permittivity such as Si. This allows tuning of the interfacial band alignment, and consequently the Schottky barrier height, in a much more drastic way than in conventional semiconductors.
Sparsity-based super-resolution for offline handwriting recognition (2011)

We present a sparsity-based approach to super-resolution for handwritten document images, and demonstrate that it improves handwriting recognition accuracy. Given high resolution training images, low and high resolution dictionaries are constructed by extracting patches. The low resolution patches are adapted to expected distortions in the out-ofdomain test data using image filters. The intuition is that the low-resolution patches would match with artifacts in the test images and the pristine high-resolution patches would be back-projected to get a high-resolution version of test image. Patches from test images are projected onto the lowresolution dictionary under sparsity constraints. The projections coefficients are used to back-project high-resolution dictionary elements for super-resolution. Our experiments indicate that this super-resolution produces substantial improvements in handwriting recognition over bicubic. An important feature is the use of a separate, out-of-domain high resolution dataset for learning the dictionary and adapting it due to the unavailability of high resolution versions of the test data.
The Origin of the Positive Effect of Cadmium Acetate on the Action of Supported Palladium Catalysts (1998)

An unusually strong promoter effect on Pd catalysts is obtained from the complex [CdPd(CH3COO)4⋅CH3COOH]2 (depicted on the right), which could be isolated from a solution of Pd(OAc)2 and Cd(OAc)2 in acetic acid. In the total oxidation of ethylene, supported catalysts prepared from this precursor complex exhibited a higher catalytic activity than catalysts prepared from binary palladium acetate.