gebhart/patrepeval huggingface dataset:
Supplementary Materials and Methods from Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein (2023)

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Expression of Ia antigen-like molecules on cells in the corneal epithelium. (1979)

Ia antigens, known to be expressed preferentially on cells of the immune system, have been shown to be present on cells in the cornea. By immunofluorescence studies, it was shown that a specific rabbit anti-Ia antigen serum stained cells in the corneal epithelium. The stained cells were well integrated into the corneal epithelial architecture and displayed short dendritic processes. Their location in the cornea and corneal limbus and their morphological appearance make it reasonable to suggest that the Ia antigen-expressing cells of the cornea are equivalents of the Ia antigen-bearing Langerhans' cells of the epidermis.
Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of Carbon Monoxide (2011)

Analysis of the complete genome of Thermococcus sp. strain AM4, which was the first lithotrophic Thermococcales isolate described and the first archaeal isolate to exhibit a capacity for hydrogenogenic carboxydotrophy, reveals a proximity with Thermococcus gammatolerans, corresponding to close but distinct species that differ significantly in their lithotrophic capacities.
ChemInform Abstract: REACTION OF CARBONYL ISOTHIO(SELENO)CYANATES WITH TRIVALENT PHOSPHORUS ESTERS (1976)

Abstract Acetylisoselenocyanat (II), das aus Acetylchlorid (I) und Kaliumselenocyanat hergestellt wird, reagiert mit Phosphiten (III) zu Phosphonsäure‐Derivaten (IV).
REVIEWS (1978)

REVIEWS Get access Mitton and the English Revolution, By C. HILL. Pp. xviii+541. London: Faber & Faber, 1977. £12.50. MICHAEL WATTS MICHAEL WATTS Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume XXIX, Issue 2, October 1978, Pages 600-b–602, https://doi.org/10.1093/jts/XXIX.2.600-b Published: 01 October 1978
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero (2008)

As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self-reactive cells. Here, we show that the human fetal immune system takes advantage of an additional mechanism: the generation of regulatory T cells (Tregs) that suppress fetal immune responses. We find that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of CD4+CD25highFoxP3+ Tregs that suppress fetal antimaternal immunity and persist at least until early adulthood. These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth.
Stochastic Contention Resolution With Short Delays (1998)

We study contention resolution protocols under a stochastic model of continuous request generation from a set of contenders. The performance of such a protocol is characterized by two parameters: the maximum arrival rate for which the protocol is stable and the expected delay of a request from arrival to service. Known solutions are either unstable for any constant injection rate or have at least polynomial (in the number of contenders) expected delay. Our main contribution is a protocol that is stable for a constant injection rate, while achieving logarithmic expected delay. We extend our results to the case of multiple servers, with each request being targeted for a specific server. This is related to the optically connected parallel computer (or OCPC) model. Finally, we prove a lower bound showing that long delays are inevitable in a class of protocols including backoff-style protocols, if the arrival rate is large enough (but still smaller than 1).
High Rate Testing of Composite Fastener Joints With and Without Clamp-up (2018)

The NASA Advanced Composites Consortium (ACC) High Energy Dynamic Impact (HEDI) group has been investigating experimentally the effects of testing speed and fastener clamp-up on the behavior of single lap shear composite fastener joints. Two fastener types, a titanium pin and a Hi-LokÂ® fastener, were used to simulate the two conditions of clamp-up force (zero and non-zero). The tests were performed at the rates of 21Ã—10-6 m/s, 2.54 m/s, 7.62 m/s, and 12.7 m/s. Strain gages and digital image correlation (DIC) were used to measure deformations, displacements, and strain fields. This paper elaborates results from tests conducted at 12.7 m/s for pin and Hi-LokÂ® fastener types. While the strains at bearing failure initiation appeared to be slightly rate sensitive for test articles employing pin joints, no trend could be associated with that for the fastener joints. The strain levels corresponding to bearing failure initiation were much higher for test articles using Hi- LokÂ® joints (with washers), because of the clamp-up. The strain rates measured at a remote location for the pin and the Hi-LokÂ® joint approached 200 s-1 and
Generalized interpolation for motion compensated prediction (2011)

Fractional sample interpolation with FIR filters is commonly used for motion compensated prediction (MCP). The FIR filtering can be viewed as a signal decomposition using restricted basis functions. The concept of generalized interpolation provides a greater degree of freedom for selecting basis functions. We implemented generalized interpolation using a combination of short IIR and FIR filters. An efficient multiplication-free design of the algorithm that is suited for hardware implementation is shown. Compared to a 6-tap FIR interpolation filter, average rate savings of 3.1% are observed. A detailed analysis of the complexity and memory bandwidth cycles compared to existing interpolation techniques for MCP is provided.
Supplementary Table 3 from Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma (2023)

Supplementary Table 3 from Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma
Electric Propulsion of a Different Class: The Challenges of Testing for MegaWatt Missions (2012)

Peer Reviewed
Adaptive work stealing with parallelism feedback (2007)

We present an adaptive work-stealing thread scheduler, A-Steal, for fork-join multithreaded jobs, like those written using the Cilk multithreaded language or the Hood work-stealing library. The A-Steal algorithm is appropriate for large parallel servers where many jobs share a common multiprocessor resource and in which the number of processors available to a particular job may vary during the job's execution. A-Steal provides continual parallelism feedback to a job scheduler in the form of processor requests, and the job must adaptits execution to the processors allotted to it. Assuming that the job scheduler never allots any job more processors than requested by thejob's thread scheduler, A-Steal guarantees that the job completes in near-optimal time while utilizing at least a constant fraction of the allotted processors.
CTNI-58. A PROSPECTIVE TRIAL OF RESECTION AND SURGICALLY TARGETED RADIATION THERAPY FOR INITIAL OR SALVAGE TREATMENT OF AGGRESSIVE MENINGIOMA (2020)

Abstract INTRODUCTION Achieving durable local control (LC) for aggressive or recurrent meningiomas remains problematic. Resection (R) alone is insufficient and even with the addition of radiation therapy (RT), outcomes are suboptimal in many series. OBJECTIVE Hypothesizing R plus Surgically Targeted Radiation Therapy (STaRT) may improve LC, we evaluated a permanently implanted brachytherapy device consisting of Cs-131 seeds positioned within modular resorbable collagen carrier/spacer tiles (GammaTile, GT Medical Technologies, Tempe AZ). METHODS From 2/2013-2/2018 recurrent and newly diagnosed aggressive meningiomas were treated on a prospective single-arm study (NCT#03088579). At completion of maximum safe resection the tumor bed was lined with collagen tiles imbedded with Cs-131, delivering 60–80 Gy at 5 mm depth. No additional local therapy was given absent progression. RESULTS 35 meningiomas in 28 patients were treated; 29 recurrent (22 prior R+RT, 6 R only, and 1 RT only) and 6 without prior therapy. WHO grade was I in 2 patients, II in 28, and III in 5. Median age was 66 years (range 37–82), KPS 80 (70–100), female: male ratio 15:13. Mean time for implantation was 5 minutes. At a median radiographic follow-up of 25.5 months (range 0.1–71) LC was 80% (28/35) and median time to progression had not been reached (95% CI &amp;gt; 35.6 months). LC at 12/24/36/48 months was 100/89/72/72% for all tumors, 100/93/79/79% for Grade II, and 100/50/0/0% for Grade III, respectively. No patient receiving STaRT as their initial RT failed. Median overall survival was 50 months. Four symptomatic adverse events occurred, 2 wound breakdowns requiring surgery and 2 radiation-related brain changes, medically treated. CONCLUSION R+STaRT demonstrates favorable safety and LC outcomes in this single-arm prospective trial that includes heavily pre-treated patients. A commercial version of the device recently received FDA clearance for use in newly diagnosed malignant or recurrent intracranial neoplasms including meningiomas.
Fluid permeabilities of triply periodic minimal surfaces (2005)

It has recently been shown that triply periodic two-phase bicontinuous composites with interfaces that are the Schwartz primitive (P) and diamond (D) minimal surfaces are not only geometrically extremal but extremal for simultaneous transport of heat and electricity. The multifunctionality of such two-phase systems has been further established by demonstrating that they are also extremal when a competition is set up between the effective bulk modulus and electrical (or thermal) conductivity of the bicontinuous composite. Here we compute the fluid permeabilities of these and other triply periodic bicontinuous structures at a porosity using the immersed-boundary finite-volume method. The other triply periodic porous media that we study include the Schoen gyroid (G) minimal surface, two different pore-channel models, and an array of spherical obstacles arranged on the sites of a simple cubic lattice. We find that the Schwartz P porous medium has the largest fluid permeability among all of the six triply periodic porous media considered in this paper. The fluid permeabilities are shown to be inversely proportional to the corresponding specific surfaces for these structures. This leads to the conjecture that the maximal fluid permeability for a triply periodic porous medium with a simply connected pore space at a porosity is achieved by the structure that globally minimizes the specific surface.
ChemInform Abstract: Asymmetric Alkylations of a Sultam‐Derived Glycinate Equivalent: Practical Preparation of Enantiomerically Pure α‐Amino Acids. (1990)

Abstract The chiral sultam (I) derived from camphorsulfonic acid, is coupled with the N‐(bis(methylthio)methylene)glycinate (II) to form the sulfonamide (III).
Parametric Maps of Extraordinary Optical Transmission Through Arrays of Metallic Nanoscale Slits (2011)

We present a method of expedient visualization that clearly maps operative mechanisms of extraordinary optical transmission (EOT) in parametric space. The parametric maps reveal the essential physics of EOT through one-dimensional slit arrays.
Statistical Modeling and Reconstruction of Rebinned PET Measurements (2022)

Positron emission tomography (PET) provides insight into the physiology of living subjects and is an invaluable tool for the detection and staging of cancer. A PET scanner detects photons emitted from targeted regions inside the body and reconstructs them into images. These emission measurements are inherently noisy due to the limitations of the detection system and the physics of the decay. Consequently, this noise causes poor representations of the region of interest and ultimately complicates diagnoses. One primary method for reducing the influence of the noise is to improve the models used in the image reconstruction. This dissertation defends that the statistics of the PET measurements provide valuable information for improving the system and data model.In particular, this work develops a successful method for estimating geometric system parameters directly from data measurements. These parameters are then used to accurately describe the system model. Along with refining the system model, this research improves the data model for rebinned PET measurements. Rebinning represents an approach for simplifying high sensitivity 3D PET data into a form that can be quickly reconstructed into a meaningful image. The proposed improved data models are incorporated into direct and statistical reconstruction algorithms, leading to techniques tailored for the statistics of rebinned measurements. Results prove that some of the new tailored methods significantly outperform conventional 2D reconstruction algorithms.
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening (2023)

Enediyne antibiotics are a striking family of DNA-cleaving natural products with high degrees of cytotoxicity and structural complexity. Microbial genome sequences, which have recently accumulated, point to an untapped trove of "cryptic" enediynes. Most of the cognate biosynthetic gene clusters (BGCs) are sparingly expressed under standard growth conditions, making it difficult to characterize their products. Herein, we report a fluorescence-based DNA cleavage assay coupled with high-throughput elicitor screening for the rapid, targeted discovery of cryptic enediyne metabolites. We applied the approach to <i>Streptomyces clavuligerus</i>, which harbors two such BGCs with unknown products, identified steroids as effective elicitors, and characterized 10 cryptic enediyne-derived natural products, termed clavulynes A-J with unusual carbonate and terminal olefin functionalities, with one of these congeners matching the recently reported jejucarboside. Our results contribute to the growing repertoire of enediynes and provide a blueprint for identifying additional ones in the future.
Emerging area: biomaterials that mimic and exploit protein motion (2011)

Traditional dynamic hydrogels have been designed to respond to changes in physicochemical inputs, such as pH and temperature, for a wide range of biomedical applications. An emerging strategy that may allow for more specific "bio-responsiveness" in synthetic hydrogels involves mimicking or exploiting nature's dynamic proteins. Hundreds of proteins are known to undergo pronounced conformational changes in response to specific biochemical triggers, and these responses represent a potentially attractive toolkit for design of dynamic materials. This "emerging area" review focuses on the use of protein motions as a new paradigm for design of dynamic hydrogels. In particular, the review emphasizes early examples of dynamic hydrogels that harness well-known protein motions. These examples then serve as templates to discuss challenges and suggest emerging directions in the field. Successful early examples of this approach, coupled with the fundamental properties of nature's protein motions, suggest that protein-based materials may ultimately achieve specific, multiplexed responses to a range of biochemical triggers. Applications of this new class of materials include drug delivery, biosensing, bioactuation, and tissue engineering.
EUV lithography industrialization progress (2017)

This presentation will provide an overview of the industrialization of EUV Lithography, including the latest data on imaging, overlay, defectivity and source power/ productivity. The focus of the presentation will be on the NXE:3400B scanner, ASML’s fifth generation EUV lithography tool intended for the sub 10 nm volume production Furthermore the ASML roadmap, NXE:3300B and NXE:3350B field data and field performance data will be shown
Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70null flies (2008)

Modification of Hsp70 copy number quantitatively and qualitatively affects the expression of multiple other stress-response genes. A positive association between absolute expression levels of Hsp70 and other Hsps after thermal pretreatment suggests novel regulatory mechanisms. Severe heat shocks induce both novel gene expression patterns and almost total mortality in the Hsp70 null strain: alteration of gene expression in this strain does not compensate for Hsp70 loss but suggests candidates for overexpression studies.
3D Nano-characterisation of materials by FIB-SEI/EDS tomography (2010)

Focus ion beam-tomography is able to characterize materials from > 10 nm. The 3D-volumes are generated from serial FIB cross-sections, which can be imaged by the different modes of a scanning electron microscope (SEM) like secondary electrons (SE), energy-dispersive X-ray spectroscopy analysis (EDS), etc. This article reports on different examples of FIB-tomography in Al-alloys and porous Ni sample, as well as on the different methods for an adequate sectioning and imaging of the serial cross sections.
Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method. (1999)

Protein-losing enteropathy is frequently overlooked in patients suffering from congestive heart failure. Although textbooks often quote heart failure as one of the causes of protein-losing enteropathy, this association has not been clearly documented in the literature. Furthermore, conventional diagnostic techniques for protein-losing enteropathy are both cumbersome and time-consuming. We report the first case of protein-losing enteropathy of a 79 year-old lady who suffered from dilated cardiomyopathy. The profound hypoalbuminemia could not be explained by urinary loss or impaired hepatic synthesis. Protein-losing enteropathy was confirmed by means of Technetium-99m- (99mTc) labelled human serum albumin scintigraphy which showed diffuse activity in the entire colon. The use of this simple and non-invasive diagnostic technique in protein-losing enteropathy is discussed.
ChemInform Abstract: BIS(DINITROGEN) AND DIETHYLENE COMPLEXES OF MOLYBDENUM(0) (1982)

Abstract Der Molybdänkomplex (I) reagiert mit Ethylen (II) zum Komplex (III), der in Lösung von Kohlenwasserstoffen mit (V) im Gleichgewicht steht.
Dispersion of Polymer-Grafted Nanorods in Homopolymer Films: Theory and Experiment (2013)

An understanding of the dispersion of nanoparticles into polymer melts is needed in order to control material properties of polymer nanocomposites. Here we study the dispersion of polymer-grafted nanorods in homopolymer melts of the same chemistry, using both experiment and theory. The theoretical calculations are performed over the range of experimental system parameters. Polymer-grafted gold nanorods (Au NRs) were found to be dispersed when the matrix chain lengths were small relative to the brush chain lengths, and aggregated at higher matrix chain lengths. Both classical density functional theory (DFT) and self-consistent field theory (SCFT) are used to calculate the structure of a polymer brush around an isolated NR in a polymer melt. Both theories predict a gradual transition from a “wet” to a “dry” brush as the grafting density, the NR radius, and/or the ratio of matrix to brush chain lengths is increased. DFT calculations of the interaction free energy between two NRs find an attractive well at intermediate NR separations, with a repulsive barrier at closer NR separations. The strength of the attraction increases as the brushes become more dry. Including the van der Waals attractions between the NRs gives an estimate of their total interaction free energy, which can be used to predict at which values of the system parameters the NRs are dispersed or aggregated. A dispersion map shows good agreement between DFT calculations and experimental observations of dispersed and aggregated nanorods.
Preoperative Nomograms for Predicting Extracapsular Extension in Korean Men with Localized Prostate Cancer: A Multi-institutional Clinicopathologic Study (2010)

We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5%) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy.
Early estimation of defect density using an in-process Haskell metrics model (2005)

Early estimation of defect density of a product is an important step towards the remediation of the problem associated with affordably guiding corrective actions in the software development process.This paper presents a suite of in-process metrics that leverages the software testing effort to create a defect density prediction model for use throughout the software development process.A case study conducted with Galois Connections, Inc. in a Haskell programming environment indicates that the resulting defect density prediction is indicative of the actual system defect density.
High-energy collision-induced dissociation mass spectrometry of synthetic mannose-6-phosphate oligosaccharides (1996)

The high-energy collision-induced dissociation spectra of a series of linear and branched synthetic mannosyl oligosaccharides that contain 6-phosphate substituents on either or both non-reducing terminal or penultimate residues have been studied. These phosphorylated structures were designed to mimic those of naturally derived N-glycans (Man-6-PO4) on lysosomal enzymes and to probe the minimally required binding motif for the Man-6-PO4 receptors. When a phosphate group was present, the spectra were dominated by ions that arise from cleavages at the glycosidic bonds (single and double) with charge retention on the phosphate-containing fragments. The spectra of linear structures that bear the nonreducing terminal Man-6-phosphate residues were devoid of Y-type ions, unlike those with similar phosphorylation at the penultimate residue. The location of the phosphorylated residue was deduced from the presence or absence of unique B and Y ions. In neutral branched structures, the ions were formed by cleavage at the glycosidic bond at either one or both of the branch points and the aglycon, which was attached to the disubstituted mannosyl residue. Branched oligosaccharides that contained one or two terminal Man-6-PO4 residues also showed double cleavages with charge retention on the phosphate-containing fragment. Our investigation shows that positive mode high energy collision-induced dissociation mass spectrometry can determine the location-terminal or penultimate-of Man-6-PO4 residues in N-linked type oligosaccharides.