gebhart/patrepeval huggingface dataset:
Syntheses selectives de o-glycosides et d'azotures de glycosyle a partir de sucres non proteges - proprietes amphiphiles (1994)

Le travail presente dans ce memoire concerne la synthese et l'evaluation des proprietes physico-chimiques de nouveaux amphiphiles glucidiques ainsi que la preparation d'azotures de glycosyle a partir de donneurs non proteges. Dans un premier chapitre bibliographique, nous rappelons les principales methodes de o-glycosidation des hexoses actuellement utilisees pour la preparation d'oligosaccharides ou de glycoconjugues. Dans le second chapitre, nous decrivons une nouvelle methodologie de synthese stereoselective soit de glycofuranosides d'alkyle, soit de glycopyranosides d'alkyle. Nous nous sommes attaches a la recherche de reactions simples permettant d'acceder a des molecules de structures parfaitement definies. Nous avons ainsi synthetise des 1,2-trans-glycofuranosides d'alkyle derives du glucose, du galactose et du mannose, ainsi que des 1,2-cis-glycopyranosides derives du glucose, du mannose, de la n-acetyl-d-glucosamine et du fructose. A notre connaissance, ces reactions figurent parmi les toutes premieres glycosylations selectives d'alcools gras sans phenomene d'oligomerisation, au depart d'aldohexoses et d'un cetohexose non proteges. L'evaluation des proprietes tensioactives et de cristaux liquides lyotropes et thermotropes des composes amphiphiles originaux a fait l'objet du chapitre iii. Cette partie est egalement consaccree a la comparaison de ces proprietes avec celle des glycopyranosides isomeres. Le chapitre iv est consacre a un rappel bibliographique concernant les principales methodes de n-glycosylation et sur la preparation et les applications des azotures de glycosyle. Dans un second temps, nous decrivons une nouvelle voie d'acces stereoselective a des 1,2-cis-azotures de glycosyle a partir de sucres reducteurs non proteges
Silver-catalyzed 1,2-acyl migration in an optically active chlorohydrin. Evidence for neighboring-group participation by carbonyl carbon (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilver-catalyzed 1,2-acyl migration in an optically active chlorohydrin. Evidence for neighboring-group participation by carbonyl carbonJohn M. Domagala and Robert D. BachCite this: J. Am. Chem. Soc. 1979, 101, 11, 3118–3120Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/ja00505a048https://doi.org/10.1021/ja00505a048research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A new model for physical layer security in cellular networks (2014)

In this paper, we study physical layer security for the downlink of cellular networks. In a cellular network, the confidential messages transmitted to each mobile user can be eavesdropped by the other users in the same cell and also by the users in the other cells. We model the locations of base stations and mobile users as two independent two-dimensional Poisson point processes. By combining tools from stochastic geometry and random matrix theory, we analyze the secrecy rates achievable with regularized channel inversion (RCI) precoding under Rayleigh fading. Our analysis shows that unlike isolated cells, the secrecy rate in a cellular network does not grow monotonically with the transmit power. Moreover, we find that the network tends to be in secrecy outage if the transmit power grows unbounded. Furthermore, we show that there exists an optimal value for the base station deployment density that maximizes the secrecy rate.
Low Switching Frequency Deadbeat-Direct Torque and Flux Control of Wound Field Synchronous Machines (2018)

Enhancements to the deadbeat-direct torque and flux control (DB-DTFC) of wound field synchronous machines (WFSMs) are proposed allowing for operation at low switching frequency to fundamental frequency ratios. Discrete time current and flux linkage observers which properly model WFSM d-q and d-f cross-coupling are formed using a Taylor series approximated sampled Laplace approach. The affect of the Taylor series order on the discretization error and model accuracy is examined. The torque curve to determine the inverter voltage commands is derived from the flux linkage model coefficients. Experimental comparison of the WFSM torque response is made between the classical DB-DTFC with current and flux observers formed using a z-transform approach and the torque line derived from a forward Euler method and the newly proposed observers and torque curve.
A simple model of reverse roll coating (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple model of reverse roll coatingDennis J. Coyle, Christopher W. Macosko, and L. E. ScrivenCite this: Ind. Eng. Chem. Res. 1990, 29, 7, 1416–1419Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ie00103a046https://doi.org/10.1021/ie00103a046research-articleACS PublicationsRequest reuse permissionsArticle Views510Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Synthesis of endo,endo‐2,5‐Bis((diphenylphosphino)methyl)bicyclo‐(2.2.1)heptane, a Chelating Diphosphine with a Natural Bite Angle of 120°. (1990)

Abstract Reaction of the diketone (I) with the methylenephosphorane (II) produces the bismethylene derivative (III) which is hydroborated to give the diol (IV) after oxidative work‐up.
Topical Silver Treatment After Escharectomy of Infected Full Thickness Burn Wounds in Rats (2005)

White male Sprague Dawley rats (200 g.) with 20% full thickness scald burns seeded with 10 Pseudomonas aeruginosa, strain 59-1244, were used as experimental animals. Studies including the following: (1). Control groups. (2). DC pretreatment groups. (3). Treatment groups. P. aeruginosa infected burn wounds were excised, and then treated with either autograft or silver-nylon dressings, with (SNDC) or without (SN) application direct current. Excision and treatment were initiated 1, 2, 3, 4 or 5 days after burning and inoculation. (4). Groups for antimicrobial barrier function study. Mortality of each group was recorded at 21 days PB. With burns alone, there was no mortality. Without treatment 19 of 20 burn inoculated controls died. In the pretreatment study, the mortality of the group pretreated with SN was 95% while that of the group pretreated with SNDC was only 30%. With excision and autografting, PB mortality rose from 5/20 at day 2 PB to 19/20 at day 3 PB. In the excision and SN groups, mortality rose from 5/20 at day 3 PB to 18/20 at day 4 PB. In the excision and SNDC groups, mortality rose from 5/20 at day 3 PB to 18/20 at day 4 PB. In the antimicrobial barrier function study, the 10% mortality in the SN dressing group was significantly less than that of 95% in the plain nylon dressed group. Histologic examination revealed progressively deepening colonization of non-viable wound tissue, progressing to invasion of underlying viable tissue by PB day 4. With wound excision, SN, SNDC, and autografting were equally protective for the first two days, but only SN and SNDC extended this effect to the third PB day. In conclusion, SN and SNDC have a strong local anti-microbial effect on the burn wound when applied within 72 hours of the time of bacterial inoculation, but little effect if applied after the bacteria have invaded unburned vessels and viable tissue adjacent to the burn.
A Novel Role of Histone Deacetylase 11 (HDAC11) in Regulation of Myeloid-Derived Suppressor Cell (MDSC) Expansion (2011)

Abstract Abstract 2439 HDAC11 is the newest member of the HDAC family. The physiological role of this HDAC was largely unknown until the discovery by our group that HDAC11 regulates IL-10 gene expression in myeloid cells in-vitro1. To better elucidate the role of HDAC11 in these cells, we have utilized an HDAC11 promoter-driven eGFP reporter transgenic mice (TgHDAC11-eGFP) which allow us to “visualize” dynamic changes in HDAC11 gene expression /transcriptional activity in immune cells in vivo. Immature myeloid cells (IMCs) differentiate into dendritic cells, macrophages, and neutrophils and are also considered to be precursors of MDSCs in tumor-bearing hosts. Here, we show for the first time that HDAC11 plays an important role in this process. First, IMCs from the bone marrow and spleen of TgHDAC11-eGFP mice display high expression of eGFP indicative of HDAC11 transcriptional activation in these cells in the steady state. Subcutaneous injection of PANCO2 tumor cells into these mice resulted in expansion of MDSCs (identified by the expression of CD11b+/GR1+ [Ly6G and Ly6C] with variable expression of CD49d and CD115) in their lymphoid organs which was similar in magnitude to the expansion observed in tumor-bearing wild type (WT) mice. Of note, flow cytometric analysis revealed that expression of eGFP was significantly decreased in the myeloid compartment of tumor bearing TgHDAC11-eGFP mice, suggesting that the transition of IMC into MDSCs might require a decrease in HDAC11 expression. Reminiscent of our findings in the eGFP mice, studies in non-transgenic mice also demonstrated that tumor derived CD11b+ Ly6G+ MDSCs display less HDAC11 mRNA expression. Additional support for the regulatory role of HDAC11 in MDSC expansion/function has been recently provided by our studies in HDAC11KO mice, demonstrating the acquisition of a suppressive cell phenotype, by myeloid cells identical to MDSCs, in the steady state and in the absence of tumor challenge. Taken together, HDAC11 might function as a negative regulator of MDSC expansion/function in vivo. A better understanding of this previously unknown role of HDAC11 in MDSC biology might lead to targeted epigenetic therapies to influence the suppressive abilities of these cells and augment the efficacy of immunotherapeutic approaches against hematologic malignancies. 1. Villagra A, et al. Nat Immunol. 2009 Jan;10(1):92-100 Disclosures: No relevant conflicts of interest to declare.
Pharmacotherapy for people with Alzheimer's disease: a Markov-cycle evaluation of five years' therapy using donepezil (1998)

This article combines data from a clinical trial of donepezil with costing figures to evaluate expected direct costs of care over 5 years after diagnosis of Alzheimer's disease (AD) for patients aged 75 years and over at diagnosis. A Markov model simulates the progression of elderly persons through changing levels of severity. The model compares three treatment regimes for each of two patient groups; mild AD at start of treatment; moderate AD at start of treatment. Patients are followed until 5 years after the start of the treatment. Despite the acquisition costs, use of donepezil is approximately cost-neutral for both 5 mg and 10 mg treatment groups and for patients initially at either mild or moderate states of illness. Expected costs are slightly higher than for the placebo group, but higher expenditure on drugs is partly offset by lower costs of care consequent on treated patients not declining as rapidly as those untreated. The model showed that donepezil patients spent less time in the state of severe dementia, where costs of care are higher. Sensitivity analysis on key assumptions demonstrated that expected costs were highly dependent on discount rate and, more significantly, on the mortality rate.
Bit-Error-Rate Evaluation of the Distributed Raman Amplified Transmission Systems in the Presence of Double Rayleigh Backscattering Noise (2007)

A new exact bit-error-rate evaluation method for distributed Raman amplification transmission systems in the presence of both amplified spontaneous emission and double Rayleigh backscattering (DRB) is developed based on a study of statistical characterization of DRB
Emerging Neural Workloads and Their Impact on Hardware (2020)

We consider existing and emerging neural workloads, and what hardware accelerators might be best suited for said workloads. We begin with a discussion of analog crossbar arrays, which are known to be well-suited for matrix-vector multiplication operations that are commonplace in existing neural network models such as convolutional neural networks (CNNs). We highlight candidate crosspoint devices, what device and materials challenges must be overcome for a given device to be employed in a crossbar array for a computationally interesting neural workload, and how circuit and algorithmic optimizations may be employed to mitigate undesirable characteristics from devices/materials. We then discuss two emerging neural workloads. We first consider machine learning models for one- and few-shot learning tasks (i.e., where a network can be trained with just one or a few, representative examples of a given class). Notably crossbar-based architectures can be used to accelerate said models. Hardware solutions based on content addressable memory arrays will also be discussed. We then consider machine learning models for recommendation systems. Recommendation models, an emerging class of machine learning models, employ distinct neural network architectures that operate of continuous and categorical input features which make hardware acceleration challenging. We will discuss the open research challenges and opportunities within this space.
Gaze interaction from bed (2011)

This paper presents a low-cost gaze tracking solution for bedbound people composed of free-ware tracking software and commodity hardware. Gaze interaction is done on a large wall-projected image, visible to all people present in the room. The hardware equipment leaves physical space free to assist the person. Accuracy and precision of the tracking system was tested in an experiment with 12 subjects. We obtained a tracking quality that is sufficiently good to control applications designed for gaze interaction. The best tracking condition were achieved when people were sitting up compared to lying down. Also, gaze tracking in the bottom part of the image was found to be more precise than in the top part.
Stacked Neural Networks for end-to-end ciliary motion analysis (2018)

Cilia are hairlike structures protruding from nearly every cell in the body. Diseases known as ciliopathies, where cilia function is disrupted, can result in a wide spectrum of disorders. However, most techniques for assessing ciliary motion rely on manual identification and tracking of cilia; this process is laborious and error-prone, and does not scale well. Even where automated ciliary motion analysis tools exist, their applicability is limited. Here, we propose an end-to-end computational machine learning pipeline that automatically identifies regions of cilia from videos, extracts patches of cilia, and classifies patients as exhibiting normal or abnormal ciliary motion. In particular, we demonstrate how convolutional LSTM are able to encode complex features while remaining sensitive enough to differentiate between a variety of motion patterns. Our framework achieves 90% with only a few hundred training epochs. We find that the combination of segmentation and classification networks in a single pipeline yields performance comparable to existing computational pipelines, while providing the additional benefit of an end-to-end, fully-automated analysis toolbox for ciliary motion.
Method of fabricating a three-dimensionally patterned mechanical energy absorptive material (2023)

A three-dimensionally patterned energy absorptive material and fabrication method having multiple layers of patterned filaments extrusion-formed from a curable pre-cursor material and stacked and cured in a three-dimensionally patterned architecture so that the energy absorptive material produced thereby has an engineered bulk property associated with the three-dimensionally patterned architecture.
Separating Texture and Illumination for Single-Shot Structured Light Reconstruction (2014)

Active illumination based methods have a trade-off between acquisition time and resolution of the estimated 3D shapes. Multi-shot approaches can generate dense reconstructions but require stationary scenes. In contrast, single-shot methods are applicable to dynamic objects but can only estimate sparse reconstructions and are sensitive to surface texture. In this work, we develop a single-shot approach to produce dense reconstructions of highly textured objects. The key to our approach is an image decomposition scheme that can recover the illumination and the texture images from their mixed appearance. Despite the complex appearances of the illuminated textured regions, our method can accurately compute per pixel warps from the illumination pattern and the texture template to the observed image. The texture template is obtained by interleaving the projection sequence with an all-white pattern. Our estimated warping functions are reliable even with infrequent interleaved projection. Thus, we obtain detailed shape reconstruction and dense motion tracking of the textured surfaces. We validate the approach on synthetic and real data containing subtle non-rigid surface deformations.
Hybrid envelope tracking for efficiency enhancement in concurrent dual‐band PAs (2012)

Abstract A hybrid envelope tracking scheme is proposed for concurrent dual‐band power amplifiers (PAs). Ideal power supply sweeping measurement shows this scheme can improve the efficiency of dual‐band PAs effectively. The feasibility of this scheme is validated using baseband and analog co‐simulation with real large signal circuit models. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:662–664, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26667
Wie kann man den Engineering-Prozess systematisch verbessern? (2013)

In diesem Beitrag werden die Ergebnisse der Arbeit des GMA-Fachausschusses 6.12 "Durchgängiges Engineering von Leitsystemen" der letzten 1½ Jahre vorgestellt und zur Diskussion gestellt. Die Ergebnisse beinhalten eine Systematik zur Einordnung der Arbeitsweise einer Engineering-Organisation bezogen auf ihr wirtschaftliches, organisatorisches und technisches Umfeld und mögliche Maßnahmen zur Weiterentwicklung einer Engineering-Organisation.
Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils (1998)

Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a massive, sustained respiratory burst that requires cell spreading. However, the signaling pathways culminating in PMN spreading are not well characterized. Studies showing that protein tyrosine phosphorylation increases with PMN spreading suggest that phosphorylation is critical for this process. In the present study, we observed increased tyrosine phosphorylation of both focal adhesion kinase and Syk in FMLP-activated PMNs that had been plated onto fibrinogen; an increase in Syk activity, but not focal adhesion kinase activity, was apparent. The time course of Syk phosphorylation correlated with the initiation of cell spreading and H2O2 release. Pretreatment of PMNs with piceatannol, a Syk-selective inhibitor, blocked Syk activity, cell spreading, and H2O2 release, indicating that Syk activity was required for the activation of adherent PMNs. Paxillin is a cytoskeletally associated protein that is also tyrosine phosphorylated during PMN spreading and H2O2 release. Paxillin phosphorylation is kinetically slower than Syk phosphorylation and is inhibited with piceatannol, suggesting that paxillin is a substrate for Syk. An analysis of Syk immunoprecipitates indicated that Syk and paxillin associate during PMN spreading. This interaction is not mediated by the src kinases Lyn and Fgr, since neither kinase coprecipitated with Syk. Syk from FMLP-activated, adherent PMNs phosphorylated paxillin-glutathione S-transferase, suggesting that paxillin is a substrate for Syk in vivo. These results indicate that PMN spreading and H2O2 release require a Syk-dependent signaling pathway leading to paxillin phosphorylation.
Conodipine-M, a Novel Phospholipase A2 Isolated from the Venom of the Marine Snail Conus magus (1995)

We describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 kDa and is comprised of two polypeptide chains linked by one or more disulfide bonds. The amino acid sequence of conodipine-M shows little if any homology to other previously sequenced phospholipase A2 enzymes (PLA2s). Conodipine-M thus represents a new group of PLA2s. This is remarkable, since conodipine-M displays a number of properties that are similar to those of previously characterized 14-kDa PLA2s. The enzyme shows little, if any, phospholipase A1, diacyglycerol lipase, triacylglycerol lipase, or lysophospholipase activities. Conodipine-M hydrolyzes the sn-2 ester of various preparations of phospholipid only in the presence of calcium and with specific activities that are comparable to those of well known 14-kDa snake venom and pancreatic PLA2s. The Conus enzyme binds tightly to vesicles of the negatively charged phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphomethanol and catalyzes the hydrolysis of this substrate in a processive fashion. Conodipine-M does not significantly discriminate against phospholipids with unsaturated versus saturated fatty acids at the sn-2 position or with different polar head groups. Linoleoyl amide and a phospholipid analog containing an alkylphosphono group at the sn-2 position are potent inhibitors of conodipine-M. We suggest that the functional resemblance of conodipine-M to other PLA2s might be explained by the utilization of similar catalytic residues.