gebhart/patrepeval huggingface dataset:
Multi frequency excited MEMS cantilever beam resonator for Mixer-Filter applications (2016)

Wireless communication uses Radio Frequency waves to transfer information from one point to another. The modern RF front end devices are implementing MEMS in their designs so as to exploit the inherent properties of MEMS devices, such as its low mass, low power consumption, and small size. Among the components in the RF transceivers, band pass filters and mixers play a vital role in achieving the optimum RF performance. And this paper aims at utilizing an electrostatically actuated micro cantilever beam resonator's nonlinear frequency mixing property to realize a Mixer-Filter configuration through multi-frequency excitation. The paper studies about the statics and dynamics of the device. Simulations are carried out to study the added benefits of multi frequency excitation. The modelling of the cantilever beam has been done using a Reduced Order Model of the Euler-Bernoulli's beam equation by implementing the Galerkin discretization. The device is shown to be able to down-convert signals from 960 MHz of frequency to an intermediate frequency around 50 MHz and 70 MHz in Phase 1 and 2, respectively. The simulation showed promising results to take the project to the next level.
Bioactivities of the Leaf Essential Oil of <I>Curcuma Longa</I> (Var. Ch-66) On Three Species of Stored-Product Beetles (Coleoptera) (2002)

Essential oil extracted from the leaves of turmeric, Curcuma longa L., was investigated for contact and fumigant toxicity and its effect on progeny production in three stored-product beetles, Rhyzopertha dominica F. (lesser grain borer), Sitophilus oryzae L. (rice weevil), and Tribolium castaneum Herbst (red flour beetle). Oviposition-deterrent and ovicidal actions of C. longa leaf oil were also evaluated against T. castaneum. The oil was insecticidal in both contact and fumigant toxicity assays. The adults of R. dominica were highly susceptible to contact action of C. longa leaf oil, with LD50 value of 36.71 microg/mg weight of insect, whereas in the fumigant assay, adults of S. oryzae were highly susceptible with LC50 value of 11.36 mg/liter air. Further, in T. castaneum, the C. longa oil reduced oviposition and egg hatching by 72 and 80%, respectively at the concentration of 5.2 mg/cm2. At the concentration of 40.5 mg/g food, the oil totally suppressed progeny production of all the three test insects. Nutritional indices indicate >81% antifeedant action of the oil against R. dominica, S. oryzae and T castaneum at the highest concentration tested.
Thermal properties of electrodeposited bismuth telluride nanowires embedded in amorphous alumina (2004)

Bismuth telluride nanowires are of interest for thermoelectric applications because of the predicted enhancement in the thermoelectric figure-of-merit in nanowire structures. In this letter, we carried out temperature-dependent thermal diffusivity characterization of a 40nm diameter Bi2Te3 nanowires∕alumina nanocomposite. Measured thermal diffusivity of the composite decreases from 9.2×10−7m2s−1 at 150Kto6.9×10−7m2s−1 at 300K and is lower than thermal diffusivity of unfilled alumina templates. Effective medium calculations indicate that the thermal conductivity along nanowires axis is at least an order of magnitude lower than thermal conductivity of the bulk bismuth telluride.
Unusually located lymphocutaneous nocardiosis caused by Nocardia brasiliensis (2006)

We report a patient with primary lymphocutaneous Nocardia brasiliensis infection affecting the face and left arm. The mode of infection was via skin abrasions which occurred 2 weeks prior to the development of the skin lesions. Treatment with intravenous minocycline for 4 weeks resulted in a cure. We also review 12 previously reported Japanese cases of lymphocutaneous nocardiosis.
SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model (2019)

The incidence of hepatocellular carcinoma (HCC) or hepatoma has steadily increased over the past few decades with the ever-increasing prevalence of both Hepatitis -B and -C viral infections and chronic liver diseases. Human HCC tumor cells express growth hormone receptors (GHRs). It has been shown that GHR signaling is important for the metabolism and progression of more than ten human cancers including breast cancer and melanoma. We hypothesized that growth hormone (GH) induced signaling is important for cell growth and metabolism in HCC. Therefore, GHR antagonism will inhibit the progression of malignancy both in vitro and in vivo. To test this hypothesis, we used a syngeneic mouse model using Hepa-1-6 murine HCC cells in C57BL6/J mice and assayed cell proliferation along with western blotting (WB), ELISA, and RT-qPCR of several genes. We observed that GHR-expressing Hepa1-6 mouse hepatoma cells had a significantly upregulated proliferative response to GH treatment. This result could be attributed to GH alone, or to both, GH and insulin-like growth factor-1 (IGF-1). We found that both IGF-1 protein and mRNA levels in Hepa1-6 cells remained unaffected irrespective of GH concentrations. Cells also failed to exhibit the same proliferative response to IGF-1 as seen with GH treatment, further substantiating the IGF-1-independent growth-promoting role of GH in the progression of HCC. To evaluate the effects of GH on the development and progression of HCC in vivo, Hepa-1-6 cells were subcutaneously inoculated into both a transgenic mouse model expressing a growth hormone antagonist (GHA) with characteristically decreased circulating IGF-1 levels but supraphysiological GH levels, and WT controls. Subsequent tumor growth was evaluated and a decreased tumor size in GHA animals was observed. Moreover, excised tumors from the GHA mice were significantly smaller by mass than those found in their WT counterparts. These results suggest a therapeutic role for GHA in offsetting the pro-tumorigenic effects of GH action on HCCs in mice. Further studies are ongoing to elucidate the effects of GH antagonism on HCC in vitro and in vivo, on specific processes like Epithelial-to-mesenchymal transition (EMT) and drug efflux. Our preliminary results implicate GH inhibition as a prospective therapeutic agent against the progression of HCC. Unless otherwise noted, all abstracts presented at ENDO are embargoed until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.
Effect of acid pre-treatment on AuPd/SiO2catalysts for the direct synthesis of hydrogen peroxide (2012)

The direct synthesis of hydrogen peroxide is investigated using silica supported Au, Pd and AuPd catalysts. Acid pre-treatment of the silica leads to an increase in the activity of the Pd-containing catalysts and also gives rise to a synergistic enhancement in activity when Au and Pd are combined that is absent in the untreated catalysts. The acid pre-treated mono and bi metallic catalysts show much reduced H2O2 hydrogenation activity compared to their untreated counterparts. The acid pre-treatment increases the concentration of the hydroxyl groups on the support, as demonstrated using inelastic neutron scattering, which helps to disperse the metals on the support. Pd can be dispersed effectively on silica, but Au is very poorly dispersed although this is enhanced marginally by the acid pre-treatment. The origin of the synergistic effect is discussed and is considered to be related to the incorporation of a small amount of Au within the Pd nanoparticles.
Preferential Cytoplasmic Localization of p34 cdc2 in Recurrent Human Squamous Cell Carcinoma after Radiotherapy (1997)

Elizabeth Cohen-Jonathan, Christine Toulas, Philippe Rochaix, Jean-Marc Bachaud, Nicolas Daly-Schveitzer, Gilles Favre, Preferential Cytoplasmic Localization of ${\rm p}34^{{\rm cdc2}}$ in Recurrent Human Squamous Cell Carcinoma after Radiotherapy, Radiation Research, Vol. 147, No. 3 (Mar., 1997), pp. 277-283
Efficient Inhibition of Human Telomerase Reverse Transcriptase Expression by RNA Interference Sensitizes Cancer Cells to Ionizing Radiation and Chemotherapy (2005)

Telomerase activation plays critical roles in tumor growth and progression in part through the maintenance of telomere structure. Indeed, the ubiquitous expression of telomerase in human cancers makes telomerase a promising target for cancer therapy. Genetic, pharmacologic, and antisense methods to inhibit telomerase have been described; however, in most cases, cancer cell death was observed only after many cell divisions. Here, using retroviral delivery of small interfering RNAs (siRNAs) specific for the human telomerase reverse transcriptase (hTERT), we successfully inhibited telomerase activity in cervical cancer cell lines. Cells lacking hTERT expression exhibited significantly decreased telomerase activity and showed shortened telomeres and telomeric 3' overhangs with passage. These cells entered replicative senescence after a considerable number of cell divisions. Notably, the proliferative rate of these cells was significantly impaired, compared with control cells with telomerase activity, even in low-passage cells (population doubling 5). Likewise, colony-forming ability and tumorigenicity in mice were attenuated in low-passage cells lacking hTERT. We further examined the effects of chemotherapy and ionizing radiation on cells in which hTERT expression was suppressed. Cells lacking hTERT showed a significantly increased sensitivity, compared with control cells, to ionizing radiation or chemotherapeutic agents that induce DNA double- strand breaks, such as topoisomerase inhibitors or bleomycin. These findings suggest that an siRNA-based strategy can be applied to the development of novel telomerase inhibitors, the antitumor effects of which may be enhanced in combination with ionizing radiation and chemotherapy.
Identification, cloning and initial characterisation of FeuPQ inBrucella suis: a new sub-family of two-component regulatory systems (1998)

To cause disease, Brucella species have to adapt to a range of different environments. Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence analysis of response regulators from Brucella species identified a response regulator sequence with 96% similarity to Rhizobium leguminosarum FeuP. In R. leguminosarum, the FeuPQ two-component system is involved in the regulation of iron uptake. A Brucella suis feuP isogenic mutant was constructed but was not attenuated in the murine brucellosis model. The survival and multiplication of the mutant in macrophages was also unaffected. The FeuPQ regulon represents a newly characterised sub-family of response regulators.
A Powder Neutron Diffraction Investigation of the Two Rhombohedral NASICON Analogues:  γ-Na3Fe2(PO4)3 and Li3Fe2(PO4)3 (2000)

The crystal structures of polycrystalline rhombohedral γ-Na3Fe2(PO4)3 and Li3Fe2(PO4)3 obtained through Na ↔ Li ion exchange have been determined for the first time, from neutron diffraction data recorded at 473 and 300 K, respectively. Na3Fe2(PO4)3 crystallizes in the space group R3̄c at 473 K (γ-form, a = 8.7270(2) Å, and c = 21.8078(5) Å). A progressive transfer of Na+ ions from the M(1) (6-coordinate) to the M(2) (8-coordinate) sites occurs upon raising the temperature from ambient (α-form, τM(1) = 1) to 393 K (β-form, τM(1) = 0.91) and then to 473 K (γ-form, τM(1) = 0.85). This is associated with a significant increase of Fe−Fe distances through the M(1) site and with relaxation of the framework such that the FeO6 octahedra become less distorted. Ion exchange from Na3Fe2(PO4)3 leads to the rhombohedral form of Li3Fe2(PO4)3 (space group R3̄; a = 8.3162(4) Å, and c = 22.459(1) Å). The M(1) and M(2) sites of the NASICON structure are empty in Li3Fe2(PO4)3 which is isotypic with Li3In2(PO4)3. Removal of Na+ from M(1) results in a strong increase of the c parameter due to stronger repulsions between adjacent FeO6 octahedral faces along [001]. Lithium is located on one single-crystallographic site, M(3), with four Li−O distances ranging between 1.91 and 2.09 Å which span a regular tetrahedral geometry and gives rise to one signal in the 6Li spectrum at 152 ppm. Two crystallographic sites are clearly distinguished for iron: Fe(1)O6 shares three of its vertexes only with LiO4 tetrahedra and is far more distorted than Fe(2)O6 which shares three edges with LiO4 tetrahedra.
A novel Aaproach to increase cell wall saccharification for efficient biofuel production (2011)

The conversion of biomass to biofuels requires heat, pressure and acid treatments to overcome the recalcitrance of the cell wall and remove lignin that hinders access to cellulose. Economic production of biofuels from lignocellulosic biomass and efficient sugar release depends on the ability to reverse and overcome this natural recalcitrance of the plant cell wall. Most of the current ideas and methods to generate lignocellulose feedstock which is more amenable to saccharification, are limited to the modification or downregulation of the lignin biosynthesis. This often results in dwarfing, xylem vessel collapse or reduced fitness to stress. In order to overcome these limitations, we present here a novel approach for cell wall remodeling. By introducing new trans-genes from algae, fungi and viruses we create “Trojan Horses: polymer pockets of enhanced solubility within the cell wall, thus increasing cellulose accessibility to solvents and enzymes. Two different methodologies are presented. The first includes transgenic introduction of soluble polysaccharides such as hyaluronan into the cell wall during its development, leading to its intercalation with the cellulose microfibrils. Upon processing, these soluble intercalated polysaccharides are washed away, resulting in highly porous cell walls with increased accessibility to hydrolytic enzymes. The second methodology involves modification of the cellulose by expression of recombinant cellobiose dehydrogenase (CDH) in plant cell walls, leading to disruption of the cellulose microcrystalline lattice and thus increasing hydrolytic enzymes accessibility. Both methodologies result in transgenic plants that exhibit significantly enhanced cellulose hydrolysis, while maintaining their physiological and structural integrity. This novel concept provides new prospects for more economical production of liquid biofuel to substitute fossil fuels.
Multi-watt, 780 nm, single-frequency CW fiber-based by SHG in PPLN and PPKTP (2005)

SHG of single-frequency CW Yb/Er fiber source in PPKTP and PPLN is investigated. 30% conversion efficiency and 9 W output power at 780 nm are demonstrated in single pass configuration. Possible applications for laser cooling are discussed.
Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis (2011)

Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this study was to ascertain whether patients with multiple sclerosis or neuromyelitis optica develop retinal neuronal layer pathology following acute optic neuritis, and to systematically characterize such changes in vivo over time. Spectral domain optical coherence tomography imaging, including automated retinal layer segmentation, was performed serially in 20 participants during the acute phase of optic neuritis, and again 3 and 6 months later. Imaging was performed cross-sectionally in 98 multiple sclerosis participants, 22 neuromyelitis optica participants and 72 healthy controls. Neuronal thinning was observed in the ganglion cell layer of eyes affected by acute optic neuritis 3 and 6 months after onset (P < 0.001). Baseline ganglion cell layer thicknesses did not demonstrate swelling when compared with contralateral unaffected eyes, whereas peripapillary retinal nerve fibre layer oedema was observed in affected eyes (P = 0.008) and subsequently thinned over the course of this study. Ganglion cell layer thickness was lower in both participants with multiple sclerosis and participants with neuromyelitis optica, with and without a history of optic neuritis, when compared with healthy controls (P < 0.001) and correlated with visual function. Of all patient groups investigated, those with neuromyelitis optica and a history of optic neuritis exhibited the greatest reduction in ganglion cell layer thickness. Results from our in vivo longitudinal study demonstrate retinal neuronal layer thinning following acute optic neuritis, corroborating the hypothesis that axonal injury may cause neuronal pathology in multiple sclerosis. Further, these data provide evidence of subclinical disease activity, in both participants with multiple sclerosis and with neuromyelitis optica without a history of optic neuritis, a disease in which subclinical disease activity has not been widely appreciated. No pathology was seen in the inner or outer nuclear layers of eyes with optic neuritis, suggesting that retrograde degeneration after optic neuritis may not extend into the deeper retinal layers. The subsequent thinning of the ganglion cell layer following acute optic neuritis, in the absence of evidence of baseline swelling, suggests the potential utility of quantitative optical coherence tomography retinal layer segmentation to monitor neuroprotective effects of novel agents in therapeutic trials.
One‐Step C‐Terminal Deprotection and Activation of Peptides with Peptide Amidase from Stenotrophomonas maltophilia in Neat Organic Solvent (2014)

Abstract Chemoenzymatic peptide synthesis is a rapidly developing technology for cost effective peptide production on a large scale. As an alternative to the traditional C → N strategy, which employs expensive N ‐protected building blocks in each step, we have investigated an N →C extension route that is based on activation of a peptide C ‐terminal amide protecting group to the corresponding methyl ester. We found that this conversion is efficiently catalysed by Stenotrophomonas maltophilia peptide amidase in neat organic media. The system excludes the possibility of internal peptide cleavage as the enzyme lacks intrinsic protease activity. The produced peptide methyl ester was used for peptide chain extension in a kinetically controlled reaction by a thermostable protease. magnified image
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐ZOAPATANOL (1981)

Abstract Ausgehend von dem Glycidether (I) wird über die Stufen (IIIa), (IIIb) und (IIIc) ‐ durch Umsetzung von (IIIc) mit dem Grignardderivat des Bromids (IV) und nachfolgende Oxidation ‐ das Keton (IIId) (Diastereomerengemisch) dargestellt, das über die Stufen (Va) und (Vb) in das Epoxid (VI) (Epimerengemisch) übergeführt wird.
Heavy hole doping of epitaxial thin films of a wide gap p-type semiconductor, LaCuOSe, and analysis of the effective mass (2007)

The high density hole doping (1.7×1021cm−3) for a wide gap (Eg=∼2.8eV) p-type semiconductor was achieved on 40nm thick Mg-doped LaCuOSe epitaxial films. These films exhibited distinct free carrier absorption, and the effective mass and momentum relaxation time were analyzed. Its small hole mobility [∼3.5cm2∕(Vs)] compared to the electron mobilities of wide gap n-type semiconductors is attributed to a heavy effective mass of 1.6±0.2me. Regardless of the heavy hole doping, a band filling effect was not observed. These results are discussed with a rigid band model and an acceptor band model.
ChemInform Abstract: ELECTRONIC EXCITATION TRANSFER IN POLYMERS. 3. SINGLET‐SINGLET, TRIPLET‐SINGLET, AND TRIPLET‐TRIPLET ENERGY TRANSFERS. EVIDENCE FOR TRIPLET MIGRATION AMONG PENDANT PHENYL GROUPS OF POLYSTYRENE (1978)

Abstract Mittels Chemilumineszenz‐Technik wird der Energieübergang von Keton‐Donatoren (Aceton, Acetophenon) auf Acceptoren ( ;z.B. 9,10‐Diphenyl‐anthracen oder Biphenyl) in Polystyrol‐ und Polymethylmethacrylat‐ Filmen bei 50°C untersucht.
1B08 Relationship between EMG signal and muscle acceleration during elbow flexion/extension (2013)

The movement ofhuman arm is controlled by muscle force.
Toroidal and magnetic spectral responses of four split-ring resonators (2011)

The toroidal as well as magnetic spectral responses at optical frequencies by integrating four gold U-shaped split-ring resonators (SRRs) are numerically studied. We study two kinds of toroidal structures; the first one is consisted of four-up U-shaped SRRs. The second kind, two of the four U-shaped SRRs is reversed showing two-up-two-down configuration. By reversing two SRRs of toroidal structure, their toroidal resonance and magnetic resonance are also reversed between higher and lower ones. The optical properties of toroidal resonance are also investigated in this paper.
IPv4 to IPv6 Transformation Schemes (2010)

According to the recent observations of IPv4 (Internet Protocol version 4) address allocation status, it will be running out within few years. Consequently, to ensure the continuous extension of the Internet operation, introducing IPv6 (Internet Protocol version 6) protocol is surely needed. But at the same time, such transformation must be “smooth” for every Internet users and be compatible with today's IPv4 based practices. This paper describes several techniques and usage scenario which are discussed mainly in the IETF — Internet Engineering Task Force — and tried to be implemented as prototype products to transform today's Internet towards the IPv6 based one.
Modeling of eddy current loss in the magnets of permanent magnet machines for hybrid and electric vehicle traction applications (2009)

The eddy current loss in the magnets of permanent magnet (PM) motors in a hybrid electric vehicle (HEV) and plugin HEV is usually not taken into consideration in traditional motor design and analysis. However, due to the high conductivity of the rare-earth magnet, neodymium-iron-boron (NdFeB), and slot/tooth harmonics, there is eddy current loss generated inside the magnets. This loss may not attribute very much to the efficiency of the motor, but the temperature-rise inside the magnets caused by this loss can lead to the unpredictable deterioration of the magnets. In addition, the output voltage of pulse-width-modulated (PWM) inverter contains abundant high frequency harmonics, which induce additional loss in the magnets. This paper presents the modeling and analysis of eddy current loss in surface-mounted-magnets of PM motors operated by PWM inverters for HEV/PHEV and electric vehicle traction applications. In order to evaluate the loss from pure sinusoidal and PWM inverter supply, an analytical method is implemented, in conjunction with time-stepped finite-element analysis (FEA). The simulation results validated the proposed model.