gebhart/patrepeval huggingface dataset:
Consequences of IPv6 Addressing (2004)

The IETF has proposed a set of protocols known collectively as IPv6 to serve as the next generation of Internet Protocols. IPv6 provides Internet-layer services with functionality similar to that of IPv4, but changes many details of addressing and address assignment.
This paper argues that the proposed changes will result in a significant redefinition of the existing Internet model, and will have substantial impact on higher layer protocols, especially applications. The paper also discusses ways in which the negative effects can be ameliorated; however, none of the available solutions can completely solve the problems introduced by the changes to the Internet addressing model.
RT-QuIC detection of tauopathies using full-length tau substrates (2020)

Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for neurodegenerative disease. Here we use full-length recombinant tau substrates to detect tau seeding activity in Alzheimer's disease and other human tauopathies.
Characterizing HEC Storage Systems at Rest (2008)

Acknowledgements: I’d like to thank my advisor Dr. Garth Gibson for working closely with me through this study and providing invaluable guidance. I wish to acknowledge James Nunez from LANL for providing timely comments and feedback on the report and helping gather data from LANL over several iterations, and Akbar Mokhtarani from NERSC and Evan Felix from PNNL for providing statistics from repeated runs over months. This report will be revised into a paper for future submission to a conference and James Nunez, Akbar Mokhtarani and Evan Felix will be coauthors on it. I also wish to thank the following people who ran fsstats on their respective sites and uploaded results to us: Brad Havel from
POLYETHYLENE DAMAGE IN TOTAL KNEES AND USE OF HIGHLY CROSSLINKED POLYETHYLENE (2003)

Muratoglu, Orhun K. PhD; Mark, Arthur MD; Vittetoe, David A. MD; Harris, William H. MD, DSc; Rubash, Harry E. MD Author Information
Oral and Intestinal Bacterial Substances Associated with Disease Activities in Patients with Rheumatoid Arthritis: A Cross-Sectional Clinical Study (2022)

Intestinal bacterial compositions of rheumatoid arthritis (RA) patients have been reported to be different from those of healthy people. Dysbiosis, imbalance of the microbiota, is widely known to cause gut barrier damage, resulting in an influx of bacteria and their substances into host bloodstreams in animal studies. However, few studies have investigated the effect of bacterial substances on the pathophysiology of RA. In this study, eighty-seven active RA patients who had inadequate responses to conventional synthetic disease-modifying antirheumatic drugs or severe comorbidities were analyzed for correlations between many factors such as disease activities, disease biomarkers, intestinal bacterial counts, fecal and serum lipopolysaccharide (LPS), LPS-binding protein (LBP), endotoxin neutralizing capacity (ENC), and serum antibacterial substance IgG and IgA antibody levels by multiple regression analysis with consideration for demographic factors such as age, sex, smoking, and methotrexate treatment. Serum LBP levels, fecal LPS levels, total bacteria counts, serum anti-LPS from <i>Porphyromonas gingivalis</i> (Pg-LPS) IgG antibody levels, and serum anti-Pg-LPS IgA antibody levels were selected for multiple regression analysis using Spearman's correlation analysis. Serum LBP levels were correlated with disease biomarker levels, such as erythrocyte sedimentation rate (<i>p</i> < 0.001), C-reactive protein (<i>p</i> < 0.001), matrix metalloproteinase-3 (<i>p</i> < 0.001), and IL-6 (<i>p</i> = 0.001), and were inversely correlated with hemoglobin (<i>p</i> = 0.005). Anti-Pg-LPS IgG antibody levels were inversely correlated with activity indices such as patient global assessments using visual analogue scale (VAS) (<i>p</i> = 0.002) and painVAS (<i>p</i> < 0.001). Total bacteria counts were correlated with ENC (<i>p</i> < 0.001), and inversely correlated with serum LPS (<i>p</i> < 0.001) and anti-Pg-LPS IgA antibody levels (<i>p</i> < 0.001). These results suggest that substances from oral and gut microbiota may influence disease activity in RA patients.
Compact low-profile planar elliptical antenna for UWB applications (2016)

This paper presents a compact low-profile elliptical planner antenna for UWB applications. The antenna is fabricated using Rogers 5880 LZ substrate, conducting patch, and conducting ground plane. The antenna size is 41.95mm×21.2 mm×1.27mm. The operating bandwidth of the designed antenna is from 2.5-10.5 GHz, which make the antenna useful for UWB applications. The length of the ground plane is selected to be 10 mm as predicted in the simulation results. HFSs simulation software is used to obtain the antenna return loss S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> and antenna gain pattern. To validate the proposed antenna design concept, a prototype is fabricated and measured. Experimental results obtained show excellent agreement with the simulation results from HFSS, and both achieved the desired bandwidth.
Semi-Flocking Algorithm for Motion Control of Mobile Sensors in Large-Scale Surveillance Systems (2014)

The ability of sensors to self-organize is an important asset in surveillance sensor networks. Self-organize implies self-control at the sensor level and coordination at the network level. Biologically inspired approaches have recently gained significant attention as a tool to address the issue of sensor control and coordination in sensor networks. These approaches are exemplified by the two well-known algorithms, namely, the Flocking algorithm and the Anti-Flocking algorithm. Generally speaking, although these two biologically inspired algorithms have demonstrated promising performance, they expose deficiencies when it comes to their ability to maintain simultaneous robust dynamic area coverage and target coverage. These two coverage performance objectives are inherently conflicting. This paper presents Semi-Flocking, a biologically inspired algorithm that benefits from key characteristics of both the Flocking and Anti-Flocking algorithms. The Semi-Flocking algorithm approaches the problem by assigning a small flock of sensors to each target, while at the same time leaving some sensors free to explore the environment. This allows the algorithm to strike balance between robust area coverage and target coverage. Such balance is facilitated via flock-sensor coordination. The performance of the proposed Semi-Flocking algorithm is examined and compared with other two flocking-based algorithms once using randomly moving targets and once using a standard walking pedestrian dataset. The results of both experiments show that the Semi-Flocking algorithm outperforms both the Flocking algorithm and the Anti-Flocking algorithm with respect to the area of coverage and the target coverage objectives. Furthermore, the results show that the proposed algorithm demonstrates shorter target detection time and fewer undetected targets than the other two flocking-based algorithms.
The Impact of Carbonation Curing on the Fatigue Behavior of Polyvinyl Alcohol Engineered Cementitious Composites (PVA-ECC) (2023)

Use of Engineered Cementitious Composites (ECC) has been proven to enhance structural fatigue resistance and reduce the use-phase emissions for transportation infrastructure. Carbonation curing offers an opportunity to reduce the embodied carbon of ECC via direct CO2 sequestration. In this study, the impact of carbonation curing on ECC’s fatigue resistance was examined. ECC’s CO2 uptake, static flexural behavior, flexural fatigue performance, and single fiber pull-out behavior were studied experimentally. Midspan deflection up to 3 million cycles under fatigue load, fatigue stress-life relationship, and failure mechanism for carbonation-cured and air-cured ECC were investigated. Carbonation curing was found to significantly improved the fatigue life of ECC and lowered the midspan deflection under the same stress. Further, CO2-cured ECC can achieve >20% CO2 uptake per cement mass after 24-hour carbonation curing. Carbonation curing increased ECC’s flexural strength by 32% and promoted crack width control capability, with maximum post-fatigue crack width reduced from 148 μm to 76 μm. The positive impact of carbonation curing on the fatigue behavior of ECC simultaneously lowers the embodied and operational carbon of ECC structural members subjected to fatigue loading during service.
Fully coherent light at 13 nm using quasi phase matching in gas-filled modulated waveguides (2004)

We demonstrate the generation of fully spatially coherent EUV light at 13 nm for the first time using high harmonic upconversion. This is a significant improvement over past work.
First Measurement of the Z→μ+μ− Angular Coefficients in the Forward Region of pp Collisions at s=13  TeV (2022)

The first study of the angular distribution of μ^{+}μ^{-} pairs produced in the forward rapidity region via the Drell-Yan reaction pp→γ^{*}/Z+X→ℓ^{+}ℓ^{-}+X is presented, using data collected with the LHCb detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.1 fb^{-1}. The coefficients of the five leading terms in the angular distribution are determined as a function of the dimuon transverse momentum and rapidity. The results are compared to various theoretical predictions of the Z-boson production mechanism and can also be used to probe transverse-momentum-dependent parton distributions within the proton.
Image processing: some challenging problems. (1993)

Image processing can be broadly defined as the manipulation of signals which are inherently multidimensional. The most common such signals are photographs and video sequences. The goals of processing or manipulation can be (i) compression for storage or transmission; (ii) enhancement or restoration; (iii) analysis, recognition, and understanding; or (iv) visualization for human observers. The use of image processing techniques has become almost ubiquitous; they find applications in such diverse areas as astronomy, archaeology, medicine, video communication, and electronic games. Nonetheless, many important problems in image processing remain unsolved. It is the goal of this paper to discuss some of these challenging problems. In Section I, we mention a number of outstanding problems. Then, in the remainder of this paper, we concentrate on one of them: very-low-bit-rate video compression. This is chosen because it involves almost all aspects of image processing.
Stability Analysis and Control of a Rotary Transformer-Based Synchronous Motor Field Excitation System (2019)

This paper analyses the stability and control of a rotary transformer-based field excitation system. Rotary transformers enable wireless and contactless power transfer to rotating components of a system such as the rotor of a wound field synchronous motor. Their use in the field excitation of synchronous motor for electric vehicle and similar applications overcomes the disadvantages associated with the traditional slip rings-brushes arrangement such as frequent maintenance requirement, significant friction losses at high speed, contact cooling issues, increased overall motor weight and size and reduced reliability and life. The rotary transformer studied in this paper is series-series compensated with the transmitter coil supplied from a single-phase inverter, and the receiver coil connected to a full bridge diode rectifier that feeds the rotor field winding. Harmonic balance technique is used to obtain a complex variable dynamic model of the system. Using this model and the concept of the bimatrix, the controllability and observability of the rotary transformer is analyzed for different output variables. The controllability and observability matrices are not of full rank indicating the existence of states which are unaffected by the control input. The concept of zero dynamics of the system is used to determine these states and the condition for the stability of the zero dynamics is determined.
Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose (2019)

Abstract A new dicationic diboronic acid structure, DBA2+ , was designed to exhibit good affinity ( K d ≈1 m m ) and selectivity toward glucose. Binding of DBA2+ to glucose changes the p K a of DBA2+ from 9.4 to 6.3, enabling opportunities for detection of glucose at physiological pH. Proton release from DBA2+ is firmly related to glucose concentrations within the physiologically relevant range (0–30 m m ), as verified by conductimetric monitoring. Negligible interference from other sugars (for example, maltose, fructose, sucrose, lactose, and galactose) was observed. These results demonstrate the potential of DBA2+ for selective, quantitative glucose sensing. The nonenzymatic strategy based on electrohydrodynamic effects may enable the development of stable, accurate, and continuous glucose monitoring platforms.
PLGA-Based Microparticles for the Sustained Release of BMP-2 (2011)

The development of growth factor delivery strategies to circumvent the burst release phenomenon prevalent in most current systems has driven research towards encapsulating molecules in resorbable polymer matrices. For these polymer release techniques to be efficacious in a clinical setting, several key points need to be addressed. This present study has investigated the encapsulation of the growth factor, BMP-2 within PLGA/PLGA-PEG-PLGA microparticles. Morphology, size distribution, encapsulation efficiency and release kinetics were investigated and we have demonstrated a sustained release of bioactive BMP-2. Furthermore, biocompatibility of the PLGA microparticles was established and released BMP-2 was shown to promote the differentiation of MC3T3-E1 cells towards the osteogenic lineage to a greater extent than osteogenic supplements (as early as day 10 in culture), as determined using alkaline phosphatase and alizarin red assays. This study showcases a potential BMP-2 delivery system which may now be translated into more complex delivery systems, such as 3D, mechanically robust scaffolds for bone tissue regeneration applications.
The characteristics and outcomes of toxin-induced massive rhabdomyolysis (2020)

Massive rhabdomyolysis seems to be the effect of coincidence of several factors rather than the myotoxic effect alone. A creatinine concentration difference between days 2 and 1 of hospitalization was a good prognostic factor for the need for further dialysis. Int J Occup Med Environ Health. 2020;33(5):661-73.
Total Syntheses of 3-epi-Litsenolide D2 and Lincomolide A (2018)

The first total syntheses of 3- epi-litsenolide D<sub>2</sub> and its enantiomer lincomolide A were achieved. The synthetic highlights of our approach include olefin cross metathesis and bromine addition to the generated double bond, followed by the regioselective HBr-elimination and intramolecular carbonylation using bis(triphenylphosphine)dicarbonylnickel. This investigation also revealed that the previously reported specific optical rotation of 3- epi-litsenolide D<sub>2</sub> should be revised.
Jean Dausset (1916-2009) (2009)

Jean Dausset nous a quittés le 6 juin 2009 à l’âge de 93 ans. Titulaire de la chaire de Médecine expérimentale de 1977 à 1987, il fut à l’origine d’une des découvertes les plus importantes jamais faites en immunologie : celle du système HLA. En 1952, il observe que le mélange de globules blancs d’un malade avec le sérum d’un autre donneur provoque une réaction d’agglutination. Il en déduit qu’il existe dans ce dernier des anticorps anti-globules blancs, et montre que ceux-ci sont le résultat ...
Investigation of double-barrier Nb-Al-AlO/sub 2/-Al-AlO/sub x/-(Al-)Nb junctions under high-frequency irradiation (2001)

We have studied experimentally the current-voltage characteristics of double-barrier Nb-Al-AlO/sub x/-Al-AlO/sub x/-(Al-)Nb junctions exposed to microwave radiation at 4.2 K. Both integer and fractional Shapiro steps were observed. A complicated behavior of the step heights was observed as a function of both the microwave power and an applied magnetic field. Reasonable agreement with the RSJ model was obtained only for the steps 0 to 2 observed in current-voltage characteristics of the junctions with a "clean" middle Al layer. A deviation from RSJ-like behavior was found for higher-order integer steps and fractional steps. Devices with a "dirty" middle Al layer displayed more significant deviation from RSJ-like behavior. Step heights vs. magnetic field dependences in some cases were found to be qualitatively different from the field dependence of the dc Josephson current.
Advanced Diagnostic and Prognostic Technologies for Gas Turbine Engine Risk Assessment (2000)

Real-time, integrated health monitoring of gas turbine engines that can detect, classify, and predict developing engine faults is critical to reducing operating and maintenance costs while optimizing the life of critical engine components. Statistical-based anomaly detection algorithms, fault pattern recognition techniques and advanced probabilistic models for diagnosing structural, performance and vibration related faults and degradation can now be developed for real-time monitoring environments. Integration and implementation of these advanced technologies presents a great opportunity to significantly enhance current engine health monitoring capabilities and risk management practices. This paper describes some novel diagnostic and prognostic technologies for dedicated, real-time sensor analysis, performance anomaly detection and diagnosis, vibration fault detection, and component prognostics. The technologies have been developed for gas turbine engine health monitoring and prediction applications which includes an array of intelligent algorithms for assessing the total ‘health’ of an engine, both mechanically and thermodynamically. This includes the ability to account for uncertainties from engine transient conditions, random measurement fluctuations and modeling errors associated with model-based diagnostic and prognostic procedures. The implementation of probabilistic methods in the diagnostic and prognostic methodology is critical to accommodating for these types of uncertainties.
Search for Diphoton Events with Large Missing Transverse Energy inpp¯Collisions at=1.8TeV (1997)

A search for new physics has been carried out in the channel $p\overline{p}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\gamma}+{E}_{T}$, as expected in various supersymmetric models. We require two photons with transverse energy ${E}_{T}^{\ensuremath{\gamma}}&gt;12\mathrm{GeV}$ and pseudorapidity $|{\ensuremath{\eta}}^{\ensuremath{\gamma}}|&lt;1.1$. The distribution of missing transverse energy ( ${E}_{T}$) is consistent with background and no events have ${E}_{T}&gt;25\mathrm{GeV}$. We set limits on production cross sections for selectron, sneutrino, and neutralino pairs, decaying into photons, which range from about 400 fb to 1 pb depending on the sparticle masses. A general limit of 185 fb (95% C.L.) is set on $\ensuremath{\sigma}(p\overline{p}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\gamma}{E}_{T}+X)$, where ${E}_{T}^{\ensuremath{\gamma}}&gt;12\mathrm{GeV}$, $|{\ensuremath{\eta}}^{\ensuremath{\gamma}}|&lt;1.1$, and ${E}_{T}&gt;25\mathrm{GeV}$.
Deficiency of GABAergic synaptic inhibition in the Kölliker–Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome (2015)

Life threatening breathing irregularity and central apnoeas are highly prevalent in children suffering from Rett syndrome. Abnormalities in inhibitory synaptic transmission have been associated with the physiopathology of this syndrome, and may underlie the respiratory disorder. In a mouse model of Rett syndrome, GABAergic terminal projections are markedly reduced in the Kölliker-Fuse nucleus (KF) in the dorsolateral pons, an important centre for control of respiratory rhythm regularity. Administration of a drug that augments endogenous GABA localized to this region of the pons reduced the incidence of apnoea and the respiratory irregularity of Rett female mice. Conversely, the respiratory disorder was recapitulated by blocking GABAergic transmission in the KF area of healthy rats. This study helps us understand the mechanism for generation of respiratory abnormality in Rett syndrome, pinpoints a brain site responsible and provides a clear anatomical target for the development of a translatable drug treatment. Central apnoeas and respiratory irregularity are a common feature in Rett syndrome (RTT), a neurodevelopmental disorder most often caused by mutations in the methyl-CpG-binding protein 2 gene (MECP2). We used a MECP2 deficient mouse model of RTT as a strategy to obtain insights into the neurobiology of the disease and into mechanisms essential for respiratory rhythmicity during normal breathing. Previously, we showed that, systemic administration of a GABA reuptake blocker in MECP2 deficient mice markedly reduced the occurrence of central apnoeas. Further, we found that, during central apnoeas, post-inspiratory drive (adductor motor) to the upper airways was enhanced in amplitude and duration in Mecp2 heterozygous female mice. Since the pontine Kölliker-Fuse area (KF) drives post-inspiration, suppresses inspiration, and can reset the respiratory oscillator phase, we hypothesized that synaptic inhibition in this area is essential for respiratory rhythm regularity. In this study, we found that: (i) Mecp2 heterozygous mice showed deficiency of GABA perisomatic bouton-like puncta and processes in the KF nucleus; (ii) blockade of GABA reuptake in the KF of RTT mice reduced breathing irregularity; (iii) conversely, blockade of GABAA receptors in the KF of healthy rats mimicked the RTT respiratory phenotype of recurrent central apnoeas and prolonged post-inspiratory activity. Our results show that reductions in synaptic inhibition within the KF induce rhythm irregularity whereas boosting GABA transmission reduces respiratory arrhythmia in a murine model of RTT. Our data suggest that manipulation of synaptic inhibition in KF may be a clinically important strategy for alleviating the life threatening respiratory disorders in RTT.