gebhart/patrepeval huggingface dataset:
Nonlinear shear and extensional rheology of long-chain randomly branched polybutadiene (1998)

We present nonlinear shear and uniaxial extensional measurements on a series of polybutadienes with varying amounts of long-chain, random branching. Startup of steady shear experiments is used to evaluate the damping function of the melts. The damping function is found to show a trend toward decreased dependency on strain with increasing branching content. Interior chains, which are believed to be responsible for changing the damping function, are calculated to comprise less than 3 wt % of the melt. Extensional measurements are used to investigate the role of branching in strain hardening. We show that samples with increased branch contents do show larger deviations of the transient Trouton ratio from the linear viscoelastic limit of three. However, we also show that the extensional data can be fit using parameters determined solely by the shear measurements. Furthermore, we show that the changes in the damping function seen in shear have little impact on extensional behavior. The extensional behavior of the melt is found to be most affected by changes in the relaxation spectra which can result from both branching and increases in the high end of the molecular weight distribution. This statement runs contrary to the often expressed view that strain hardening behavior in extension is exclusively produced by branching.
Efficacy of a Nanocochleate-Encapsulated 3,5-Diaryl-s-Triazole Derivative in a Murine Model of Graft-Versus-Host Disease (2008)

We have previously demonstrated that the compound 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole exerts immunosuppressive effects in several experimental models of autoimmunity. These results were achieved by subcutaneously administering ST1959 after dissolution in an oily vehicle, because of its poor water solubility. To circumvent this problem, we sought to determine whether nanocochleate technology could be successfully exploited to deliver ST1959 and protect mice undergoing lethal acute graft-versus-host disease (GVHD). Orally-administered encochleated ST1959 significantly protected animals from lethality, resulting in survival rates of 57% and 100% at doses of 2 and 10 mg/kg, respectively, whereas oral administration of 2 mg/kg ST1959, mixed with empty nanocochleates, was completely inactive. Increased survival was associated with diminished serum chemokine levels and donor CD8+ T cells in the spleen of ST1959-treated mice. Moreover, ST1959 treatment significantly counteracted GVHD-induced normocitic anemia by increasing hemoglobin, hematocrit, platelet, and red and white blood cell counts. Overall, these data show that orally-administered encochleated ST1959 significantly protects mice from GVHD.
Localized Surface Phonon Polariton Resonators in GaN (2015)

GaN micro-disk resonator arrays were fabricated and measured within the Restrahalen band of GaN. Far-IR spectroscopy shows evidence for localized surface phonon polariton resonances, results which are confirmed by finite-element models of the fabricated structures.
Meta‐analysis and commentary: Preemptive correction of arteriovenous access stenosis (2017)

A recent meta-analysis by Ravani et al.1 studied the effect of preemptive correction of arteriovenous dialysis vascular access vs. deferred care on the risk of access loss, based on data from 14 trials. The authors reported a nonsignificant protective treatment effect of preemptive correction on access loss, while showing a significant protective effect on thrombosis rates conferred by preemptive correction. In order to understand the results better, we revisit all steps of the analysis. First, we repeated the data extraction from all publications2-11 referenced by Ravani et al.1 and identified an obvious data extraction error pertaining the count of access losses in the control group from the paper by Mayer et al.4 Second, using the rectified data we repeated the meta-analyses with access loss as the outcome for studies that recruited patients with arteriovenous fistulae (AVF) and grafts (AVG), respectively, using a random effects model with relative risk (RR) and risk difference (RD) of access loss as the outcomes of interest. This analysis revealed—contrary to the findings reported in the manuscript in question–a significant positive effect of preemptive correction on arteriovenous access loss in the overall study population [RR 0.80 (95% CI 0.64–0.99), RD −0.07 (95% CI −0.12 to −0.02); Figure 1]. Whereas the data do not conclusively show a benefit of preemptive correction for AVG (RR = 0.87, 95% CI: 0.69–1.11), they show a significant protective effect for AVF (RR = 0.5, 95% CI: 0.29–0.86). Meta-analysis of arteriovenous access loss, overall and by access type using risk ratio as the measure of association. The findings corroborate clinical observations such as superior long-term patency of AVF and the nature of AVG failure that often involve infectious causes. In conclusion, while showing a nonsignificant trend, the available data indicate no significant protective benefit of preemptive correction in the case of AVG, but clearly supports preemptive intervention for AVF. The results presented in this Research Letter have not been submitted anywhere else, but in abstract form to the American Society of Nephrology's Renal Week 2017. A detailed analysis also discussing the problem of heterogeneity in this meta-analysis can be found on http://dx.doi.org/10.1101/179580.
Circular dichroism of VapB and VapC confirmed predicted secondary structure. (2015)

&lt;p&gt;(&lt;b&gt;A&lt;/b&gt;) The VapB and VapC CD spectra were recorded in the wavelength range of 195–255 nm as average of five scans at 20°C. Measured ellipticities, &lt;i&gt;θ&lt;/i&gt; (mdegree), were converted to molar mean residue ellipticities, [&lt;i&gt;θ&lt;/i&gt;] (degree.cm&lt;sup&gt;2&lt;/sup&gt;.dmol&lt;sup&gt;−1&lt;/sup&gt;). The assays were reproduced with at least 2 samples of each protein. (&lt;b&gt;B&lt;/b&gt;) Prediction of secondary structure by the PSIPRED algorithm using the primary sequence of the proteins. The experimental data confirmed the secondary structure predicted by computational analysis.&lt;/p&gt;
Healthcare Performance Excellence: A Comparison of Baldrige Award Recipients and Competitors (2015)

Hospitals today face pressures from a variety of stakeholders to improve performance across a comprehensive scorecard, which has become the basis for value-based purchasing and reimbursement. This study investigates relationships between the effective application of the Malcolm Baldrige Health Care version of the Criteria for Performance Excellence (HCPE) and healthcare organizational performance. There have been many studies on the value of implementing the Criteria for Performance Excellence, but due to the lack of comparable contexts and common performance measures, analysis of the differences in performance between Baldrige Award recipients and nonrecipients has been limited. This study focuses on the common context of healthcare organizations in the same geographic region along with common metrics to analyze the impact of effective HCPE application. This study compares 34 Malcolm Baldrige National Quality Award Health Care recipients (2002–2011) to 153 competitors in their geographic markets using standard Centers for Medicare & Medicaid Services (CMS) performance measures to determine if there is a relationship between the effective use of the HCPE as an organizational excellence framework and the performance of healthcare organizations. Three categories of performance were explored including the process of care (23 measures), patient experience using the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey (10 measures), and outcome of care (six measures). Process of care and patient experience data included performance from October 2009 through September 2010, and the outcomes of care measures covered performance from July 2007 through June 2010. While there was no significant difference in process of care results or outcomes between Baldrige recipients and their competitors, there was a significant difference in patient experience results. The most important finding in this study was that Baldrige recipients provided care equal to or better than competitors while at the same time providing a better patient experience. These results add to the growing evidence that the HCPE are a valid framework to align organizational design, strategy, systems, and human capital to create long-term effectiveness in an institutionalized high-performance culture.
A new model predictive control strategy for affine nonlinear control systems (1999)

This paper considers the stabilization problem for control-affine nonlinear systems. A gradient-based numerical method is proposed to solve this problem. A receding horizon strategy, from model predictive control, is used to yield a feedback control law. We show that, under certain weak assumptions, the closed-loop system is asymptotically stable. The full swing-up of the cartpole system shows the possibility of considering fast nonlinear systems.
ChemInform Abstract: STABILE MONO‐ALKOXY‐FLUORPHOSPHORANE (1973)

Abstract Methyl‐ und Phenyl‐tetrafluorphosphoran (I) bilden mit den Trimethylsilyl‐ äthern (II) die luftempfindlichen Mono‐alkoxy‐fluorphosphorane (III) und Trimethylsilylfluorid (IV).
Calculated polarizabilities of small Si clusters (2000)

The polarizabilities of Si clusters with 9 to 28 atoms are calculated using a density functional cluster method. The atomic geometries are based on those carefully optimized by energy minimization. The polarizability shows fairly irregular variation with cluster size, but all calculated values are higher than the polarizability of a dielectric sphere with bulk dielectric constant and equivalent volume.
Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors (2013)

Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological event in a wide range of illnesses and in neurodegenerative states, including Alzheimer's disease (AD). E-64 is an epoxide-containing natural product identified as a potent nonselective, calpain inhibitor, with demonstrated efficacy in animal models of AD. By use of E-64 as a lead, three successive generations of calpain inhibitors were developed using computationally assisted design to increase selectivity for Cal1. First generation analogues were potent inhibitors, effecting covalent modification of recombinant Cal1 catalytic domain (Cal1cat), demonstrated using LC-MS/MS. Refinement yielded second generation inhibitors with improved selectivity. Further library expansion and ligand refinement gave three Cal1 inhibitors, one of which was designed as an activity-based protein profiling probe. These were determined to be irreversible and selective inhibitors by kinetics studies comparing full length Cal1 with the general cysteine protease papain.
Characterization of Ti/TiN/Pt contacts on n-type 6H-SiC epilayer at 650°C (2002)

We report results of electrical characteristics of Ti/TiN/Pt contact metallization on n-type 6H-SiC epilayer as a function of impurity concentration in the range of 3.3/spl times/10/sup 17/ cm/sup -3/to 1.9/spl times/10/sup 19/ cm/sup -3/. The as-deposited contacts were rectifying, except for the highly doped sample. Only the lesser doped remained rectifying after samples were annealed at 1000/spl deg/C between .5 to 1 minute in argon. Bulk contact resistance ranging from factors of 10/sup -5/ to 10/sup -4/ /spl Omega/-cm/sup 2/ and Schottky barrier height in the range of 0.74 to 1.07 eV were obtained. The contact resistance remained appreciably stable after heat treatment at 650/spl deg/C in air for sixty-five hours. Adhesion problems associated with metal deposition on pre-processed titanium layer was not observed, indicating excellent mechanical stability. Auger electron spectroscopy (AES) revealed the out-diffusion of titanium-silicon species and probable formation of titanium carbide as the new interface layer with the 6H-SiC epilayer.
Selectors for high density crosspoint memory arrays: Design considerations, device implementations and some challenges ahead (2015)

Significant progress has been made in recent years in the research and development of Resistive RAM as future nonvolatile memory. To achieve even higher integration densities, the resistive switching element needs a two-terminal selector device, in a one-selector one-resistor (ISIR) serial cell, which enables suppression of the parasitic leakage paths in the memory array. In this paper, review a top-down approach to derive selector requirements, considering a worst-case crosspoint array model and resistive switching element characteristics. The requirements that a selector needs to meet are derived by systematic analysis of various bias schemes, considering a basic set of figures of merit, to describe array functionality and power efficiency. We furthermore briefly discuss several selector implementations to date, outlining their strengths and weaknesses. In the end, we point out selector variability impact on cell operation, which calls for even more stringent selector requirements to be met.
Extraction of semantic description of events using Bayesian networks (2002)

We use Bayesian belief networks to statistically model the trends for event detection. We automatically detect non-rigid object trajectories for object motion units. Then, we use dominant and secondary trajectories of a single object in several consecutive motion units to understand semantic actions or those of more than one object to recognize semantic interactions between objects. We demonstrate sample Bayesian networks to detect events and extract the event descriptions, such as "catch the ball", "throw the ball" and "walk".
Spontaneous Breakage of Self-Retaining Intraprostatic Stent (1990)

An unexpected late complication was observed in a patient in whom the self-retaining intraprostatic stent was inserted. Among our 32 patients in whom the device was used, instead of a long-term indwelling catheter in high operative risk patients or in those awaiting a definitive operation, the success rate was 80%, with a 20% immediate failure rate. Spontaneous breakage of the device occurred 96 days after its insertion. This device was removed endoscopically and a new unit was inserted under sonographic guidance. After 6 months the device still functioned satisfactorily.
516. Chimeric Antigen Receptors With Distinct Signaling Domains Can Reprogram T Cells (2015)

CARs have shown great promise in the field of targeted immunotherapy against cancer. These serve as a powerful tool that help redirect T cells to recognize and target tumor cells. Despite extensive clinical testing, the underlying attributes that ensure optimal T cell survival and effector functions are yet to be delineated. Here we analyze the effects of different signaling domains on the proliferation and function of CAR T cells. We report how different CAR costimulatory domains can affect cell longevity.
Serogrouping of Neisseria gonorrhoeae: Identification of Four Immunologically Distinct Acidic Polysaccharides (1976)

A series of population-specific acidic polysaccharides have been described that can be used as a basis for serogrouping of Neisseria gonorrhoeae. These polysaccharides have been designated Gc antigens, and four immunologically distinct types have been identified. With these purified serogroup antigens and appropriately absorbed antisera in hemagglutination-inhibition systems, four typing systems have been established. Their sensitivities for purified homologous antigens range from 16 to 1 mug/ml. Purified heterologus antigens fail to inhibit at concentrations of 1,000 mug/ml. Clinically isolated N. gonorrhoeae are incorporated into these systems by conversion to standardized crude Gc antigen extracts by alkaline hhydrolysis. Of the 163 strains studied, 83% could be typed; 85% of these were typed for only one serogroup. Twenty strains were typed for two serogroups, and reisolation studies demonstrated that these strains were mosaics rather than mixed cultures. Four strains from each serogroup were selected, and antisera and purified serogroup antigens were produced from them. These were identical with their respective standard serogroup antigen and antisera in hemagglutination-inhibition and immunodiffusion systems.
Signal Detection and Noise Modeling of a 1-D Pulse-Based Ultra-Wideband Ranging System and Its Accuracy Assessment (2015)

In this paper, we estimate the achievable localization error in an ultra-wideband (UWB) precise positioning system. The system is based on the time difference of arrival of narrow pulses to a multitude of base-stations. A mathematical model and simulation platform are developed to describe the behavior of the UWB indoor localization system. Limits on the location accuracy as a function of the parameters of the UWB system are described. A discussion of the dominant errors is presented including picosecond pulse generator jitter, sampling clock jitter, sampling rate, and system additive white Gaussian noise. We show a simple method to calculate the total system jitter, and describe error biasing phenomenon as the tag moves, approaching one base-station and moving away from another. Design curves are provided to determine the required specifications of the various system components to achieve a certain positioning accuracy.
Synthesis and characterization of Nb2O5@C core-shell nanorods and Nb2O5nanorods by reacting Nb(OEt)5via RAPET (reaction under autogenic pressure at elevated temperatures) technique (2006)

Abstract The reaction of pentaethoxy niobate, Nb(OEt) 5 , at elevated temperature (800 °C) under autogenic pressure provides a chemical route to niobium oxide nanorods coated with amorphous carbon. This synthetic approach yielded nanocrystalline particles of Nb 2 O 5 @C. As prepared Nb 2 O 5 @C core-shell nanorods is annealed under air at 500 °C for 3 h (removing the carbon coating) results in neat Nb 2 O 5 nanorods. According to the TEM measurements, the Nb 2 O 5 crystals exhibit particle sizes between 25 nm and 100 nm, and the Nb 2 O 5 crystals display rod-like shapes without any indication of an amorphous character. The optical band gap of the Nb 2 O 5 nanorods was determined by diffuse reflectance spectroscopy (DRS) and was found to be 3.8 eV.
Familial Glaucoma—A Pedigree Revisited With Genetic Testing After 70 Years (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing (2016)

Retinoic acid, the bioactive metabolite of beta-carotene or vitamin A, plays a pleiotropic, multifunctional role in vertebrate development. Studies in rodents revealed that a diet deficient in vitamin A results in a complex neonatal syndrome (the VAD syndrome), manifested in many organs. In humans, the function of retinoic acid (RA) extends into adulthood, where it has important roles in fertility, vision, and suppression of neoplastic growth. In recent years, it has also been suggested that retinoic acid might potentially act as a therapeutically relevant drug in attenuating or even preventing neurodegenerative diseases such as Alzheimer's disease (AD). Here, we report that VAD leads to an increase in A-beta peptide levels while only minor effects were observed on expression levels of the amyloid precursor protein (APP) processing proteinases in wild type mice. In line with these findings, rescue of hypovitaminosis reduced A-beta amount to baseline and induced sApp-alpha secretion in combination with an increase of alpha-secretase Adam10. By comparing retinoic acid treatment starting from a full nutrition status and a "VAD" situation in human neuroblastoma cells, we show that while intensities of differential gene expression were higher in replenished cells, a large overlap in AD-related, regulated genes was observed. Our data suggest that hypovitaminosis A can contribute to onset or progression of AD by increasing synthesis of A-beta peptides and that several AD-related genes such as ADAM10 or BDNF are regulated by retinoic acid. We suggest that dietary supplementation with retinoic acid derivatives is likely to have a beneficial effect on AD-pathology in individuals with hypovitaminosis and patients with normal vitamin A status.
Miniature Incandescent Lamps as Fiber-Optic Light Sources (2008)

Miniature incandescent lamps of a special type have been invented to satisfy a need for compact, rapid-response, rugged, broadband, power-efficient, fiber-optic-coupled light sources for diverse purposes that could include calibrating spectrometers, interrogating optical sensors, spot illumination, and spot heating.
Loading Molecular Hydrogen Cargo within Viruslike Nanocontainers (2008)

Space capsules: Self-organized molecular capsules based on six C-alkylpyrogallol[4]arene cavitand type molecules, held together by hydrogen bonds, can be disassembled by shearing in liquids on a rapidly rotating disk. Rapid uptake of hydrogen in the thin film on the disk is possible, which can be entrapped in the molecular capsules as they reassemble to the parent state (hexamer) in bulk solution.
ChemInform Abstract: Xylopyranoside‐Based Agonists of D‐myo‐Inositol 1,4,5‐Trisphosphate Receptors: Synthesis and Effect of Stereochemistry on Biological Activity. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.