gebhart/patrepeval huggingface dataset:
Thrombocytopenia in Trypanosomiasis (1975)

In all of four patients with African trypanosomiasis, thrombocytopenia was present on admission to hospital or developed during the course of the illness. One patient with severe thrombocytopenia died following gastrointestinal haemorrhage shortly after admission to hospital. Kinetic studies in the other three patients showed marked pooling of platelets in the spleen in all, but severe shortening of platelet life-span in only one. Evidence of disseminated intravascular coagulation (DIC) was found in 3 patients, 2 of whom received heparin therapy. These findings provide evidence that thrombocytopenia is a feature of African trypanosomiasis and is due mainly to hypertrophy of the reticuloendothelial system which accompanies the infection. In some patients immune damage to platelets or platelet consumption as part of DIC may be an additional factor contributing to the thrombocytopenia.
P018 CERTOLIZUMAB PEGOL IS EFFECTIVE IN PATIENTS REGARDLESS OF CRP LEVEL AND DISEASE DURATION: DATA FROM PRECISE 2 (2007)

Background and Aim: Thalidomide has been shown to be an effective treatment in Crohn' s disease (CD). We retrospectively assessed the efficacy and tolerability of thalidomide in refractory CD patients. Methods: Twenty-five patients with CD (eight luminal, 11 fistulising, 4 luminal and fistulising, 2 perianal ulcerating disease) refractory to standard therapy, including infliximab, were treated for a mean of 32 weeks. All patients had active luminal disease with a Crohn`s Disease Activity Index (CDAI) > 200 and/or draining fistulising disease. Thalidomide was started at a dose of 50mg or 100mg at night and increased stepwise if tolerated. Retrospective "estimated" CDAIs were assessed at baseline and at end of follow-up. Clinical response was defined as symptomatic improvement and a reduction in the "estimated" CDAI of >100 points, >50% reduction in draining fistulas or clinical improvement in perianal ulcers. Clinical remission was defined as symptom resolution and an "estimated" CDAI < 150, complete fistula closure, or complete ulcer healing. Results: Six of eight patients treated for luminal disease responded to thalidomide at a median follow-up of 12 months (3 clinical responses, 3 clinical remissions). The median reduction in "estimated" CDAI was 212 points (p=0.005). Nine of eleven patients with active fistulising disease responded to thalidomide (6 responses; 3 remissions). The four patients treated for both luminal and fistulising disease had fistula response. Three of them had a response in luminal disease activity. One of two patients with ulcerating perianal disease responded. Three of seven steroid-dependent patients discontinued steroids. Twelve patients discontinued treatment because of adverse effects (3 sedation; 2 abdominal pain; 1 leucopenia; 6 neuropathy).
Time-Resolved Resonance Raman Observation of the 2-Fluorenylnitrenium Ion Reaction with Guanosine to Form a C8 Intermediate (2005)

Time-resolved resonance Raman spectroscopy was used to directly observe the reaction of the 2-fluorenylnitrenium ion with guanosine to produce a C8 intermediate species. Comparison of the Raman spectra with results of density functional theory calculations indicates the C8 intermediate forms two C=N conjugated bonds in ring 1 of the guanosine moiety.
Distribution of carboxypeptidase M on lymphoid and myeloid cells parallels the other zinc-dependent proteases CD10 and CD13 (1995)

Monoclonal antibody (MoAb) M27 was generated after immunization of mice with the human B-lineage acute lymphoblastic leukemia cell line Pre-ALP. Under reducing conditions, MoAb M27 precipitated a 60-kD surface-membrane molecule from Pre-ALP cells. Expression cloning of Pre-ALP cDNA showed that M27 recognizes carboxypeptidase M (CPM), a cell-surface, zinc-dependent protease known to cleave off basic C-terminal amino acids from peptide hormones. Using M27 antibody, CPM was detected only at discrete B lymphocyte developmental stages, namely on committed precursors and on germinal center cells. CPM was also expressed on mature T cells, mainly after activation. These results provide the first description of a carboxy-peptidase on lymphoid cells. In addition, CPM was found on granulocytes and monocytes, but not on their progenitors. Strikingly, CPM was present only on CD38+ cells, irrespective of lineage affiliation. Of interest, CPM displayed a largely overlapping distribution with the CD10 and CD13 peptidases, with which it shares common substrates (enkephalins, bradykinin). Collectively, the present data show a previously unrecognized distribution pattern of CPM on lymphoid and myeloid cells and suggest that CPM may cooperate with CD10 and CD13 to regulate biologic activity of peptide hormones on leukocytes.
Machine programming (2022)

Machine programming is an emerging research area that improves the software development life cycle from design through deployment. We present a tutorial on machine programming research highlighting aspects relevant to the data systems community. We divide this tutorial into three parts: We begin with an introduction to machine programming introducing its three pillars: intention, invention, and adaptation. Then, we provide an overview of the data ecosystem central to all machine programming systems, highlighting challenges and novel opportunities relevant to the data systems community. Finally, we describe recent advances in machine programming research and how these directions use various data sets to improve the ease of creating and maintaining performant software systems.
The Synthesis and Light Absorption Behaviour of Novel Coumarin Chromophores (2014)

The synthetic route to coumarin systems is well established and one approach of particular interest leads to the intermediate 7-diethylamino-3-formylcoumarin. A combination of the N,N-diethylamino-coumarin donor with a wide range of acceptor groups of varying electron withdrawing strength should permit the synthesis of a series of extended coumarin dyes with absorption maxima range from 500 to 600 nm, or even beyond. In this communication, a novel efficient synthesis of indoles, benzothiazole and benzoxazole based on coumarin chromophores were achieved and the coloristic and fluorophoric properties of these chromophores were studied.
Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality (2019)

Contemporary chemical biology and drug discovery are increasingly focused on the discovery of inhibitory molecules that interact with enzyme targets in specific ways, such as allosteric or orthosteric binding. Hence, there is increasing interest in evaluating hit compounds from high-throughput diversity screening to determine their mode of interaction with the target. In this work, the common inhibition modalities are reviewed and clarified. The impact of substrate concentration, relative to substrate K<sub>M</sub>, for each common inhibition modality is also reviewed. The pattern of changes in IC<sub>50</sub> that accompany increasing substrate concentration are shown to be diagnostic of specific inhibition modalities. Thus, replots of IC<sub>50</sub> as a function of the ratio [S]/K<sub>M</sub> are recommended as a simple and rapid means of assessing inhibition modality. Finally, specific recommendations are offered for ideal experimental conditions for the determination of inhibition modality through the use of IC<sub>50</sub> replots.
AR-v7 protein expression is regulated by protein kinase and phosphatase (2015)

Failure of androgen-targeted therapy and progression of castration-resistant prostate cancer (CRPC) are often attributed to sustained expression of the androgen receptor (AR) and its major splice variant, AR-v7. Although the new generation of anti-androgens such as enzalutamide effectively inhibits AR activity, accumulating pre-clinical and clinical evidence indicates that AR-v7 remains constitutively active in driving CRPC progression. However, molecular mechanisms which control AR-v7 protein expression remain unclear. We apply multiple prostate cancer cell models to demonstrate that enzalutamide induces differential activation of protein phosphatase-1 (PP-1) and Akt kinase depending on the gene context of cancer cells. The balance between PP-1 and Akt activation governs AR phosphorylation status and activation of the Mdm2 ubiquitin ligase. Mdm2 recognizes phosphorylated serine 213 of AR-v7, and induces AR-v7 ubiquitination and protein degradation. These findings highlight the decisive roles of PP-1 and Akt for AR-v7 protein expression and activities when AR is functionally blocked.
Correlation between texture, anisotropy, and vector magnetization processes investigated by two-dimensional vector vibrating sample magnetometry in BaO(Fe2O3)6 thin film (2008)

High ferromagnetic resonance frequencies and low linewidths in BaO(Fe2O3)6 thin films are achieved by obtaining a low-dispersion of crystallite easy c axes normal to the film. X-ray diffraction and magnetic force microscopy are used to characterize texture and magnetic domain structure for a BaO(Fe2O3)6 film deposited on (0001) SiC with a MgO (111) template layer. Strong c-axis texture normal to the film is observed resulting in strong uniaxial anisotropy. The consequent vector magnetization processes due to a combination of domain wall motion and magnetization rotation are characterized by two dimensional vector coil vibrating sample magnetometry (VVSM).
Pilot testing of a membrane system for postcombustion CO<sub>2</sub> capture (2015)

This final report summarizes work conducted for the U.S. Department of Energy, National Energy Technology Laboratory (DOE) to scale up an efficient post-combustion CO2 capture membrane process to the small pilot test stage (award number DE-FE0005795). The primary goal of this research program was to design, fabricate, and operate a membrane CO2 capture system to treat coal-derived flue gas containing 20 tonnes CO2/day (20 TPD). Membrane Technology and Research (MTR) conducted this project in collaboration with Babcock and Wilcox (B&W), the Electric Power Research Institute (EPRI), WorleyParsons (WP), the Illinois Sustainable Technology Center (ISTC), Enerkem (EK), and the National Carbon Capture Center (NCCC). In addition to the small pilot design, build and slipstream testing at NCCC, other project efforts included laboratory membrane and module development at MTR, validation field testing on a 1 TPD membrane system at NCCC, boiler modeling and testing at B&W, a techno-economic analysis (TEA) by EPRI/WP, a case study of the membrane technology applied to a ~20 MWe power plant by ISTC, and an industrial CO2 capture test at an Enerkem waste-to-biofuel facility. The 20 TPD small pilot membrane system built in this project successfully completed over 1,000 hours of operation treating flue gas at NCCC. The Polaris™ membranes used on this system demonstrated stable performance, and when combined with over 10,000 hours of operation at NCCC on a 1 TPD system, the risk associated with uncertainty in the durability of postcombustion capture membranes has been greatly reduced. Moreover, next-generation Polaris membranes with higher performance and lower cost were validation tested on the 1 TPD system. The 20 TPD system also demonstrated successful operation of a new low-pressure-drop sweep module that will reduce parasitic energy losses at full scale by as much as 10 MWe. In modeling and pilot boiler testing, B&W confirmed the viability of CO2 recycle to the boiler as envisioned in the MTR process design. The impact of this CO2 recycle on boiler efficiency was quantified and incorporated into a TEA of the membrane capture process applied to a full-scale power plant. As with previous studies, the TEA showed the membrane process to be lower cost than the conventional solvent capture process even at 90% CO2capture. A sensitivity study indicates that the membrane capture cost decreases significantly if the 90% capture requirement is relaxed. Depending on the process design, a minimum capture cost is achieved at 30-60% capture, values that would meet proposed CO2 emission regulations for coal-fired power plants. In summary, this project has successfully advanced the MTR membrane capture process through small pilot testing (technology readiness level 6). The technology is ready for future scale-up to the 10 MWe size.
On The Construction of Non-coherent Space Time Codes from High-dimensional Spherical Codes (2006)

This paper analyzes the performance of noncoherent space time codes obtained from a new class of spherical codes by mapping the surface of a higher-dimensional half-sphere to the Grassmann manifold. The deployed spherical code contains a structure which can be exploited by the receiver, leading to a reasonable decoding complexity. Therefore, high-dimensional coding spaces (Grassmann manifolds) can be used as a basis for the construction. This corresponds to codes with larger block lengths, as opposite to the usual construction of space time codes from small-dimensional spaces, such as the unitary group U(n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ), where n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> is the number of transmit antennas. The construction is flexible, meaning that codes of various dimensions and rates (spectral efficiency) may be constructed. Additionally, because of the properties of the deployed mapping, the structure of the spherical codes applies to the Grassmannian constellations as well
Electronic structure of carbonyl nitrenes. Mechanism of insertion and abstraction reactions (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure of carbonyl nitrenes. Mechanism of insertion and abstraction reactionsPaul F. Alewood, Peter M. Kazmaier, and Arvi. RaukCite this: J. Am. Chem. Soc. 1973, 95, 17, 5466–5475Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/ja00798a006https://doi.org/10.1021/ja00798a006research-articleACS PublicationsRequest reuse permissionsArticle Views466Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Linear multichannel blind equalizers of nonlinear FIR Volterra channels (1997)

Truncated Volterra expansions model nonlinear systems encountered with satellite communications, magnetic recording channels, and physiological processes. A general approach for blind deconvolution of single-input multiple-output Volterra finite impulse response (FIR) systems is presented. It is shown that such nonlinear systems can be blindly equalized using only linear FIR filters. The approach requires that the Volterra kernels satisfy a certain coprimeness condition and that the input possesses a minimal persistence-of-excitation order. No other special conditions are imposed on the kernel transfer functions or on the input signal, which may be deterministic or random with unknown statistics. The proposed algorithms are corroborated with simulation examples.
A Holistic Development Framework for Hybrid Bonding (2022)

This paper presents a modeling framework to optimize the development of hybrid bonding, starting with dielectric interface interactions, chemical-mechanical polishing (CMP) process, electrical performance, and thermo-mechanical reliability. The scale of analysis extends from the atomistic effects to the system-level effects, ensuring an all-round understanding and optimization of hybrid bonded interconnects.
A Holistic Approach to Develop New Rigorous Empirical Correlation for Static Young's Modulus (2016)

Abstract Evaluating the elastic parameters of reservoir section are very essential for oil and gas industry in alleviating the risks associated with the drilling and production phases of the reservoir. These parameters are used in the optimization of the well placement, well bore instability, completion design, and draw-down limits to avoid sanding, hydraulic fracturing, reservoir subsidence and in many more applications. To carry out any aforementioned operations, a continuous profiles of rock elastic parameters are needed. Misleading estimation of elastic parameters may wrongly lead to heavy investment decisions and inappropriate field development plans. Retrieving reservoir rock samples throughout the depth of the reservoir section and performing laboratory tests on them are extremely expensive as well as time consuming. Therefore, these parameters are estimated from empirical correlations. Most of the previous models/correlations were developed using linear or non-linear regression techniques. Artificial intelligence tool once optimized for training can successfully model elastic parameters since these tools are capable of capturing highly complex and non-linear relationship between the input parameters and the target parameter. The objective of this study is to develop a robust and an accurate model for static Young's modulus based on the wireline logs as an input using three artificial intelligence tools (artificial neural network, adaptive neuro fuzzy inference system and support vector machine). The data on which these AI models are built comprises of more than 680 real field data points from different fields covering a wide range of values. Based on the minimum error and the highest coefficient of determination between actual and simulated data artificial neural network is selected as the proposed AI model to predict static Young's modulus. A comparison between the static Young's moduli predicted by the proposed model with the published models /correlations reveals that neural network model gives significantly less average absolute percentage error. Finally, a rigorous empirical correlation is developed using the weights of ANN model in order to make the AI black box model as a white box and universal that can be usable for field applications.
In UteroExposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy (2015)

Congenital heart defects (CHD) are the most common birth anomaly and while many resolve spontaneously by 1 year of age, the lifelong burden on survivors is poorly understood. Using a rat model of chemically induced CHD that resolve postnatally, we sought to characterize the postnatal changes in cardiac function, and to investigate whether resolved CHD affects the ability to adapt to the increased the cardiovascular (CV) burden of pregnancy. To generate rats with resolved CHD, pregnant rats were administered distilled water or dimethadione (DMO) [300 mg/kg b.i.d. on gestation day (gd) 9 and 10] and pups delivered naturally. To characterize structural and functional changes in the heart, treated and control offspring were scanned by echocardiography on postnatal day 4, 21, and 10–12 weeks. Radiotelemeters were implanted for continuous monitoring of hemodynamics. Females were mated and scanned by echocardiography on gd12 and gd18 during pregnancy. On gd18, maternal hearts were collected for structural and molecular assessment. Postnatal echocardiography revealed numerous structural and functional differences in treated offspring compared with control; however, these resolved by 10–12 weeks of age. The CV demand of pregnancy revealed differences between treated and control offspring with respect to mean arterial pressure, CV function, cardiac strain, and left ventricular gene expression. In utero exposure to DMO also affected the subsequent generation. Gd18 fetal and placental weights were increased in treated F2 offspring. This study demonstrates that in utero chemical exposure may permanently alter the capacity of the postnatal heart to adapt to pregnancy and this may have transgenerational effects.
Spherical aberration yielding optimum visual performance: Evaluation of intraocular lenses using adaptive optics simulation (2009)

There was intersubject variability in the measurements; however, the mean visual performance was best with the introduction of a small positive spherical aberration.
Phase switching at low field and large sustainable strain output in domain engineered ferroic crystals (2012)

Abstract Fundamental shortcomings of ferroelectrics (FEs) are low induced strain and high electric field often required for practical application in actuation, sensors, and acoustics. Although domain engineered FE single crystals deliver an order of magnitude improvement, fatigue remains another drawback in achieving reliable multiple domain switching crucial for memory storage. We demonstrate that under specially compressive stresses FE relaxors exhibit low field induced reversible and sustainable strain associated with FE–FE phase switching and unusual and unexpected lack of fatigue after several millions cycles is believed due to strain accommodation occurring in ferroics. Polarized light microscopy and X‐ray diffraction are in a very good agreement with macroscopic observation and phenomenological model confirming proposed transformational path. The phenomena presented in this work are envisioned to be universal in domain engineered ferroics enabling mechanical stress to be used for strain and polarization control of electromechanical energy conversion.
The Effect of Co-rumination on Adolescent Depression: Mediating Effect of Rumination and Empathy (2021)

본 연구에서는 청소년의 공동 반추 관계가 반추와 공감을 통해 우울 증감에 양가적 영향을 주는 경로를 검증하고자 하였다. 이를 위해 만 15세 이상 17세 이하의 청소년 411명을 대상으로 설문을 진행하였으며, 수집된 자료를 바탕으로 공동 반추와 우울 관계에서 반추와 공감의 이중 매개 효과를 분석하였다. 분석 결과는 다음과 같다. 첫째, 공동 반추가 우울에 직/간접적으로 미치는 영향은 유의하지 않은 것으로 나타났다. 둘째, 공동 반추는 자책을 증가시켰고, 증가한 자책이 자기 지향적 공감을 증가시키는 경로로 우울이 증가하였다. 셋째, 공동 반추는 숙고를 증가시켰고, 증가한 숙고가 인지적 공감을 증가시키는 경로로 우울이 감소하였다. 이와 같은 결과는 공동 반추가 복합적인 구성 개념이며, 우울에 양가적 영향을 줄 수 있음을 의미한다. 본 연구는 공동 반추가 우울에 영향을 미치는 과정에 대한 세부적인 이해를 제공하고, 공동 반추 관계를 적응적으로 이끌 방향성을 제시했다는데 주요한 의의가 있다.