gebhart/patrepeval huggingface dataset:
Data from Mitochondrial/Cell-Surface Protein p32/gC1qR as a Molecular Target in Tumor Cells and Tumor Stroma (2023)

&lt;div&gt;Abstract&lt;p&gt;A tumor homing peptide, LyP-1, selectively binds to tumor-associated lymphatic vessels and tumor cells in certain tumors and exhibits an antitumor effect. Here, we show that the protein known as p32 or gC1q receptor is the receptor for LyP-1. Various human tumor cell lines were positive for p32 expression in culture, and the expression was increased in xenograft tumors grown from the positive cell lines. Fluorescence-activated cell sorting analyses with anti-p32 antibodies showed that p32-positive cell lines expressed p32 at the cell surface. These cells bound and internalized LyP-1 peptide in proportion to the cell-surface expression level, which correlated with malignancy rather than total p32 expression in the cells. Like the LyP-1 peptide, p32 antibodies highlighted hypoxic areas in tumors, where they bound to both tumor cells and cells that expressed macrophage/myeloid cell markers and often seemed to be incorporated into the walls of tumor lymphatics. Significant p32 expression was common in human cancers and the p32 levels were often greatly elevated compared with the corresponding normal tissue. These results establish p32, particularly its cell-surface–expressed form, as a new marker of tumor cells and tumor-associated macrophages/myeloid cells in hypoxic/metabolically deprived areas of tumors. Its unique localization in tumors and its relative tumor specificity may make p32 a useful target in tumor diagnosis and therapy. [Cancer Res 2008;68(17):7210–8]&lt;/p&gt;&lt;/div&gt;
Gateway placement for latency and energy efficient data aggregation [wireless sensor networks] (2004)

We propose the use of multiple gateways to significantly reduce latency and energy consumption in multi-hop wireless sensor networks during data aggregation. We have derived efficient integer linear programming formulations as well as a novel negative selection statistically-tuned heuristics. The heuristics are based on newly developed relaxation based lower bounds that are also used to quantify the effectiveness of the proposed heuristics. Our simulation study indicates that the use of gateways can often reduce latency and energy consumption by several times.
Waveguide dispersion effects in silicon-on-insulator coupled-resonator optical waveguides (2010)

The dispersion of the waveguides that constitute microring resonators can considerably affect the dispersion characteristics of coupled-resonator optical waveguides (CROWs). We derive expressions for CROW dispersion and group delay for silicon-on-insulator microring CROWs, showing both theoretically and experimentally the band-to-band dependence of the bandwidth and group delay on the dispersion properties of the constituent single-mode silicon waveguide.
Target transformation factor analysis with linear inequality constraints applied to spectroscopic-chromatographic data (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTarget transformation factor analysis with linear inequality constraints applied to spectroscopic-chromatographic dataPaul J. GemperlineCite this: Anal. Chem. 1986, 58, 13, 2656–2663Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/ac00126a018https://doi.org/10.1021/ac00126a018research-articleACS PublicationsRequest reuse permissionsArticle Views230Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract A27: Airway molecular alterations associated with premalignant lesion progression and lung cancer development (2012)

Abstract Recently, the National Lung Screening Trial reported a 20% reduction in lung cancer mortality and lung cancer chemoprevention trials targeting the arachidonic acid pathway have demonstrated decreases in lung cancer associated markers. These studies highlight possibilities for future reductions in lung cancer mortality through early detection and chemoprevention. Our group has previously identified smoking- and lung cancer-specific gene expression alterations in cytologically normal airway epithelial cells that can serve as a clinically-relevant biomarker for the early detection of lung cancer. Here, in an effort that could lead to markers of lung cancer risk, we identify changes in these cells associated with regression of premalignant airway lesions. Airway epithelial cells were collected via bronchoscopy from patients with bronchial dysplasia at baseline, on-treatment, and post-treatment with green tea extract (GTE) or placebo ranging from 2 to 6 months (n=27 patients, n=63 samples). RNA from the samples was processed and hybridized to Affymetrix Human Gene 1.0 ST microarrays. A linear mixed effect model was used to identify a gene expression signature predictive of subsequent dysplasia regression. Further a paired t-test was used to identify genes associated with dysplasia regression over time. Using gene set enrichment analysis (GSEA) we identified that the baseline dysplasia regression signature was enriched (FDR&amp;lt;0.05) among genes whose altered expression was associated with: dysplasia regression over time; the presence or future development of lung cancer; and human bronchial biopsies at successive morphological stages of lung squamous carcinogenesis. The genes associated with dysplasia regression were validated small cohorts of independent samples from chemoprevention trials testing Sulindac, Myo-inositol, and GTE. Analysis of the Connectivity Map identified compounds that reverse the dysplasia regression signature in vitro and are therefore candidate chemoprevention agents. Our studies suggest that the airway “field of injury” is modulated by bronchial premalignant lesions. The molecular signatures identified may be important tools for stratifying high-risk smokers for chemoprevention trials, as surrogate endpoints of efficacy in these trials, and for identification of novel molecular targets for chemoprevention. In addition, the molecular signature of regression of airway dysplasia may have additional utility as a biomarker predictive of the presence of or future lung cancer development. Citation Format: Jennifer Ebel Beane, Kahkeshan Hijazi, Katrina Steiling, Gang Liu, Sherry Zhang, Stephen Lam, Marc Lenburg. Airway molecular alterations associated with premalignant lesion progression and lung cancer development. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr A27.
Erhöhte Anreicherung von F-18-DCFPyL in den Spinalganglien eines Mausmodells für schmerzhafte rheumatoide Arthritis (2020)

Ziel/Aim Der PSMA-spezifische PET-Tracer F-18-DCFPyL reichert sich nicht nur in Läsionen des Prostatakarzinoms, sondern auch in den Spinalganglien aufgrund deren physiologischer PSMA-Expression an. Da PSMA-Inhibitoren bei der Therapie chronischer Schmerzen wirksam sind, liegt eine Beteiligung dieses Enzyms bei der spinalen Schmerzverarbeitung nahe. Wir untersuchten mit F-18-DCFPyL-PET die ganglionäre PSMA-Expression in Abhängigkeit von der Schmerzsensitivität in einem Mausmodell für rheumatoide Arthritis.
RIDS: Implicit Detection of a Selection Gesture Using Hand Motion Dynamics During Freehand Pointing in Virtual Reality (2022)

Freehand interactions with augmented and virtual reality are growing in popularity, but they lack reliability and robustness. Implicit behavior from users, such as hand or gaze movements, might provide additional signals to improve the reliability of input. In this paper, the primary goal is to improve the detection of a selection gesture in VR during point-and-click interaction. Thus, we propose and investigate the use of information contained within the hand motion dynamics that precede a selection gesture. We built two models that classified if a user is likely to perform a selection gesture at the current moment in time. We collected data during a pointing-and-selection task from 15 participants and trained two models with different architectures, i.e., a logistic regression classifier was trained using predefined hand motion features and a temporal convolutional network (TCN) classifier was trained using raw hand motion data. Leave-one-subject-out cross-validation PR-AUCs of 0.36 and 0.90 were obtained for each model respectively, demonstrating that the models performed well above chance (=0.13). The TCN model was found to improve the precision of a noisy selection gesture by 11.2% without sacrificing recall performance. An initial analysis of the generalizability of the models demonstrated above-chance performance, suggesting that this approach could be scaled to other interaction tasks in the future.
Inhibition of choline uptake byN-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood–brain barrier (2005)

The blood-brain barrier (BBB) choline transporter (CHT) may have utility as a drug delivery vector for drugs that act in the central nervous system. Previous studies suggested the importance of hydrophobic moieties on the cationic nitrogen of choline for improved affinity for this transporter. In a pilot study, we therefore designed five novel N-cycloalkyl derivatives of choline, one of which showed promising inhibition properties. This choline analogue had a cyclohexyl (UMBB-5) moiety substituting one of the methyl groups attached to the cationic nitrogen in choline. In situ experimental data were obtained from in situ rat brain perfusion studies. The binding affinity for the BBB-choline transporter found for UMBB-5 was K(i)=1.9 microM. Comparative molecular field analysis (CoMFA) suggested that the cyclohexyl moiety orientates towards a steric favourable area. Taken together, the results of these in situ and in silico studies provide further evidence or restrictions that occur with binding to this brain drug delivery vector.
Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma (2010)

Waldenstrom's macroglobulinemia (WM) is a distinct clinicopathologic entity resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphocytes, lymphoplasmacytic cells, and plasma cells which secrete a monoclonal IgM protein (Figure 12.1). This condition is considered to correspond to the lymphoplasmacytic lymphoma (LPL) as defined by the Revised European–American Lymphoma (REAL) and World Health Organization (WHO) classification systems. Most cases of LPL are WM, with less than 5% of cases made up of IgA, IgG, and non-secreting LPL.
Low-overhead byzantine fault-tolerant storage (2007)

This paper presents an erasure-coded Byzantine fault-tolerant block storage protocol that is nearly as efficient as protocols that tolerate only crashes. Previous Byzantine fault-tolerant block storage protocols have either relied upon replication, which is inefficient for large blocks of data when tolerating multiple faults, or a combination of additional servers, extra computation, and versioned storage. To avoid these expensive techniques, our protocol employs novel mechanisms to optimize for the common case when faults and concurrency are rare. In the common case, a write operation completes in two rounds of communication and a read completes in one round. The protocol requires a short checksum comprised of cryptographic hashes and homomorphic fingerprints. It achieves throughput within 10% of the crash-tolerant protocol for writes and reads in failure-free runs when configured to tolerate up to 6 faulty servers and any number of faulty clients.
Two-Mode Semiconductor Laser for mm-Wave in Radio over Fiber Transmission (2010)

In this investigation, an mm-wave RoF transmission link with dual beat-mode optical source is investigated. We demonstrate a 170 GHz band millimeter-wave source using an external dual-mode-locked Fabry-Perot laser diode (FP-LD) with a 1.38 nm mode-spacing. Two distributed feedback (DFB) lasers are used to inject the corresponding modes of FP-LD to generate dual-beat-mode output. The proposed dual-mode laser is not only stable, but also has single-longitudinal-mode (SLM) output characteristics. Moreover, we also investigate the relationship between two external-injected wavelengths for the dual-wavelength output.
Ultrafast Ultrasound Imaging of Ocular Anatomy and Blood Flow (2016)

Newly developed high-frequency linear arrays in combination with plane-wave techniques present opportunities for the evaluation of ocular anatomy and blood flow, as well as visualization and analysis of other transient phenomena such as vessel wall motion over the cardiac cycle and saccade-induced vitreous motion.
The relationship between binocular rivalry and strabismic suppression. (1985)

Increment-threshold spectral sensitivity functions were determined for normal observers during binocular rivalry and for esotropic observers during strabismic suppression and under viewing conditions that normally induce binocular rivalry. Depending on the spatial and temporal properties of the test stimulus, the normal observers exhibited a wavelength-specific loss in sensitivity during the suppression phase of rivalry, which suggests that binocular rivalry differentially attenuates the sensitivity of the chromatic mechanisms relative to the luminance mechanisms. In contrast, regardless of the test stimulus dimensions, the esotropic observers did not manifest a wavelength-specific loss in sensitivity either during strabismic suppression or under conditions that normally induce binocular rivalry. The different patterns of suppression shown by the normal and esotropic subjects suggest that strabismic observers do not demonstrate normal binocular rivalry, and that strabismic suppression and normal binocular rivalry suppression are mediated by different neural mechanisms.
Second-Order Nonlinear Optical Devices In Poled Polymers (1990)

Guest-host poled polymer films have become an active area of research as potential candidates for second-order nonlinear optical and electro-optic devices. This interest derives mainly from their large nonlinear optical coefficients, ease of fabrication, and high optical quality. Progress has been rapid in producing stable, efficient materials, and in building demonstration devices. The second-order nonlinear optical properties arise from the orientational order induced in a collection of highly nonlinear molecules incorporated in a glassy polymer matrix. After reviewing the alignment physics, we present results of nonlinear optical measurements on a methacrylate polymer functionalized with a dicyanovinyl terminated azo dye. Device issues concerning nonlinear optical devices are described with-particular attention to phase-matching. We present data on the demonstration of anomalous-dispersion phase matched second harmonic generation in dye solutions. We also present results on electro-optic modulators.
Data from <i>PIK3CA</i> C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3K<b>α</b> Inhibitors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We describe herein a novel P447_L455 deletion in the C2 domain of &lt;i&gt;PIK3CA&lt;/i&gt; in a patient with an ER&lt;sup&gt;+&lt;/sup&gt; breast cancer with an excellent response to the PI3Kα inhibitor alpelisib. Although &lt;i&gt;PIK3CA&lt;/i&gt; deletions are relatively rare, a significant portion of deletions cluster within amino acids 446–460 of the C2 domain, suggesting these residues are critical for p110α function.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A computational structural model of &lt;i&gt;PIK3CA&lt;/i&gt;&lt;sup&gt;delP447-L455&lt;/sup&gt; in complex with the p85 regulatory subunit and MCF10A cells expressing &lt;i&gt;PIK3CA&lt;/i&gt;&lt;sup&gt;delP447-L455&lt;/sup&gt; and &lt;i&gt;PIK3CA&lt;/i&gt;&lt;sup&gt;H450_P458del&lt;/sup&gt; were used to understand the phenotype of C2 domain deletions.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Computational modeling revealed specific favorable inter-residue contacts that would be lost as a result of the deletion, predicting a significant decrease in binding energy. Coimmunoprecipitation experiments showed reduced binding of the C2 deletion mutants with p85 compared with wild-type p110α. The MCF10A cells expressing &lt;i&gt;PIK3CA&lt;/i&gt; C2 deletions exhibited growth factor–independent growth, an invasive phenotype, and higher phosphorylation of AKT, ERK, and S6 compared with parental MCF10A cells. All these changes were ablated by alpelisib treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; C2 domain deletions in &lt;i&gt;PIK3CA&lt;/i&gt; generate PI3K dependence and should be considered biomarkers of sensitivity to PI3K inhibitors. &lt;i&gt;Clin Cancer Res; 24(6); 1426–35. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Distributed implementation of coordinated multi-cell beamforming (2009)

A distributed implementation of coordinated multi-cell beamforming with single-antenna users in a time-correlated fading scenario is considered. The minimum power beamformers are obtained locally at each base station (BS) relying on limited backhaul information exchange between adjacent BSs. The original centralised problem is reformulated such that the BSs are coupled by real-valued inter-cell interference terms. The problem is then decoupled by a standard dual decomposition approach leading to a distributed algorithm. The method is able to guarantee feasible solutions even if the interference information is incomplete or outdated. Occasional high peaks in the transmitted power due to outdated interference terms are alleviated by switching to interference nulling mode when necessary. The performance of the proposed coordinated multi-cell transmission is compared with the coherent multi-cell beamforming, as well as, with interference nulling in different time-correlated fading scenarios with varying interference. The numerical examples demonstrate that a near-optimal performance can be achieved even with significantly reduced backhaul information exchange and with relatively high velocities and/or low signalling rates.
Homogeneous chitosan‐PLGA composite fibrous scaffolds for tissue regeneration (2007)

Novel chitosan-poly(lactide-co-glycolide) (PLGA) composite fibers and nonwoven fibrous scaffolding matrices were designed for cartilage regeneration. A homogenous one-phase mixture of chitosan and PLGA at a ratio of 50:50 (w/w %) was successfully produced using cosolvents of 1,1,1,3,3,3-hexafluoroisopropanol and methylene chloride. A wet spinning technique was employed to fabricate composite fibrous matrices. Physical characterizations of one-phase chitosan-PLGA composite (C/Pc) matrices were performed for their homogeneity, in vitro degradability, mechanical property and wettability in comparison to two-phase chitosan and PLGA composite fibrous matrices in which PLGA was dispersed in a continuous chitosan phase. The one-phase property of C/Pc matrices was confirmed from thermal analysis. Significantly retarded degradation was observed from the composite C/Pc fibrous matrices in contrast to the PLGA-dispersed chitosan (C/Pd) fibrous matrices due to the effective acid-neutralizing effect of chitosan on acid metabolites of PLGA. The composition of chitosan with PLGA resulted in a characteristic soft and strong mechanical property that could not be retained by either PLGA or the chitosan fibers. In addition, the presence of chitosan in the composite matrices provided proper wettability for cell cultivation. The C/Pc matrices were further investigated for their scaffolding function using chondrocytes for cartilage regeneration. Enhanced cell attachment was observed on the composite matrix compared with the PLGA fibrous matrices. The mRNA expression of type II collagen and aggrecan was upregulated in the composite matrix owing to the superior cell compatibility of chitosan. These results suggest an excellent potential for C/Pc one-phase composite fibrous matrices as scaffolding materials for tissue regeneration.
A Role for Adrenergic Receptors in the Uterotonic Effects of Ergometrine in Isolated Human Term Nonlaboring Myometrium (2017)

These results provide novel evidence for a role for α-adrenergic signaling mechanisms in the action of ergometrine on human myometrial smooth muscle in the in vitro setting. Information that sheds light on the mechanism of action of ergometrine may have implications for the development of further uterotonic agents.
Development of energy‐rich protein bars and in vitro determination of angiotensin I‐converting enzyme inhibitory antihypertensive activities (2022)

Three energy-rich protein (ERP) bars were prepared to meet the daily recommended dietary allowance (RDA) for the protein of Pakistani athletes. The bars were developed using dates, cheddar cheese (CC), whey protein isolate (WPI), roasted chickpea flour, and rice flour in different proportions. Bar #1 contained 64 g dates, 16 g dried apricots, 12 g WPI, and 8 g ripened CC. Bar #2 contained the same proportion of these ingredients with an addition of 12.5 g roasted chickpea flour, while bar #3 contained 6.25 g roasted rice and 6.25 g roasted chickpea flour. All the ingredients were homogeneously mixed into paste to form bars weighing 100-110 g per serving size. These bars were studied for the compositional analysis (moisture, protein, and lipid content), protein characterization through sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and in vitro determination of the angiotensin I-converting enzyme (ACE-I) antihypertensive activity. Moisture and lipid content in bars were 22% and 0.057%-0.313%, respectively, while protein, fiber, and ash contents varied from 22.3% to 23.6%, 6.66 to 5.81, and 2.12% to 2.44%, respectively. The minimum energy content was recorded (272.70 Kcal/100 g) in bar #1 while bar #3 showed the highest energy content 274.65 Kcal/110 g with the addition of (5%) roasted chickpea and rice flour, respectively. Electrophoresis analysis of proteins in bar # 1 (cheese +WPI) showed the four bands at 62, 24, 20, and 12 kDa. Bar #2 (10% roasted chickpea flour) showed some additional bands at 40, 36, 34, and 28 kDa while relatively lower antihypertensive activity than bars #1 and 3. The study revealed that adding 10% roasted chickpea flour (bar #2) increased the protein content and diversity in proteins. It provided 40% proteins to athletes and could be helpful to meet their R.D.A. by consuming two bars/day.