gebhart/patrepeval huggingface dataset:
Solution‐Processable Carbon Nanotube Nanohybrids for Multiplexed Photoresponsive Devices (2021)

Abstract Here, the formation of carbon nanotube (CNT)‐based nanohybrids in aqueous solution is reported, where DNA‐wrapped CNTs (DNA‐CNTs) act as templates for the growth of PbS and CdS nanocrystals, toward the formation of PbS‐DNA‐CNT and CdS‐DNA‐CNT heterostructures. Solution‐processed multiplexed photoresponsive devices are fabricated from these nanohybrids, displaying a sensitivity to a broad range of illumination wavelengths (405, 532, and 650 nm). The DNA‐CNT and CdS‐DNA‐CNT devices show a drop in the current while PbS‐DNA‐CNT's current increases upon light illumination, indicating a difference in the operational mechanisms between the hybrids. Furthermore, the ON/OFF photoresponse of PbS‐DNA‐CNT is only 1 s as compared to 200 s for the other two nanohybrid devices. The mechanisms of the different photoresponses are investigated by comparing the performance under an inert and air atmosphere, and gate dependence device analysis and transient absorption spectroscopy measurements are also conducted. The results reveal that photoinduced oxygen desorption is responsible for the slower photoresponse by DNA‐CNT and CdS‐DNA‐CNT, while photoinduced charge transfer dominates the much faster response of PbS‐DNA‐CNT devices. The strategy developed is of general applicability for the bottom‐up assembly of CNT‐based nanohybrid optoelectronic systems and the fabrication of solution‐processable multiplexed devices.
Human Plasma Lecithin-Cholesterol Acyltransferase (1989)

Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyzes the transacylation of the sn-2-fatty acid of lecithin to cholesterol, forming lysolecithin and cholesteryl ester. We have recently proposed a covalent catalytic mechanism for LCAT in which lecithin cleavage proceeds via the formation of a transition state tetrahedral adduct between the oxygen atom of the catalytic serine residue and the sn-2-carbonyl carbon atom of the substrate (Jauhiainen, M., Ridgway, N.D., and Dolphin, P.J. (1987) Biochim. Biophys. Acta 918, 175-188). This proposal is evaluated here by use of nonhydrolyzable sn-2-difluoroketone phosphatidylcholine analogues, known to inhibit calcium-dependent phospholipase A2. These compounds inhibited the calcium-independent phospholipase A2 activity of LCAT in a time and concentration dependent manner. The most potent analogues had a 100-fold higher affinity for the enzyme than the substrate, lecithin, when present within lecithin/apoA-I proteoliposomes. The inhibition was dependent upon the presence of a difluoromethylene group alpha to the sn-2-carbonyl carbon of the analogues. The inhibition is attributed to the formation of a tetrahedral adduct between the catalytic serine residue of LCAT and the sn-2-carbonyl carbon atom of the analogues which is stabilized by the electronegative fluorine atoms present upon the carbon atom alpha to the carbonyl carbon. This adduct mimics that proposed by us to occur during lecithin cleavage by LCAT, and the data substantiate the existence of this transition state adduct prior to the release of lysolecithin and formation of a fatty acylserine oxyester of the enzyme.
Whole brain 3D MR fingerprinting in multiple sclerosis: a pilot study (2021)

3D-MRF has the ability to differentiate between MS and controls based on relaxometry properties from the F-NAWM and splenium. Whole brain coverage allows the assessment of quantitative properties within lesions that provide chronological assessment of the time from MS diagnosis.
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs (2017)

The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin condition actinic keratosis. IngMeb is proposed to exert its therapeutic effects through a dual mode of action involving (i) induction of cell death that is associated with mitochondrial dysfunction followed by (ii) stimulation of a local inflammatory response, at least partially driven by protein kinase C (PKC) activation. Although this therapeutic model has been well characterized, the complete set of molecular targets responsible for mediating IngMeb activity remains ill-defined. Here, we have synthesized a photoreactive, clickable analogue of IngMeb and used this probe in quantitative proteomic experiments to map several protein targets of IngMeb in human cancer cell lines and primary human keratinocytes. Prominent among these targets was the mitochondrial carnitine-acylcarnitine translocase SLC25A20, which we show is inhibited in cells by IngMeb and the more stable analogue ingenol disoxate (IngDsx), but not by the canonical PKC agonist 12-<i>O</i>-tetradecanoylphorbol-13-acetate (TPA). SLC25A20 blockade by IngMeb and IngDsx leads to a buildup of cellular acylcarnitines and blockade of fatty acid oxidation (FAO), pointing to a possible mechanism for IngMeb-mediated perturbations in mitochondrial function.
Fluid compartments influence elastography of the aging mouse brain (2023)

<i>Objective</i>. Elastography of the brain has the potential to reveal subtle but clinically important changes in the structure and composition as a function of age, disease, and injury.<i>Approach</i>. In order to quantify the specific effects of aging on mouse brain elastography, and to determine the key factors influencing observed changes, we applied optical coherence tomography reverberant shear wave elastography at 2000 Hz to a group of wild-type healthy mice ranging from young to old age.<i>Main results</i>. We found a strong trend towards increasing stiffness with age, with an approximately 30% increase in shear wave speed from 2 months to 30 months within this sampled group. Furthermore, this appears to be strongly correlated with decreasing measures of whole brain fluid content, so older brains have less water and are stiffer. Rheological models are applied, and the strong effect is captured by specific assignment of changes to the glymphatic compartment of the brain fluid structures along with a correlated change in the parenchymal stiffness.<i>Significance</i>. Short-term and longer-term changes in elastography measures may provide a sensitive biomarker of progressive and fine-scale changes in the glymphatic fluid channels and parenchymal components of the brain.
Intravitreal Aminoglycoside Toxicity Revisited-Reply (1992)

<h3>In Reply.</h3> —We thank Dr Pulido et al for their valuable comments concerning aminoglycoside toxicity. We agree with their premise that, like most biologic phenomena, drug toxicity has a certain amount of variability among individuals. We also agree that their evaluation of the data of Zachary and Forster suggests that the above premise applies to retinal toxicity from intravitreous aminoglycosides and supports the contention that doses of gentamicin sulfate previously considered safe might be toxic in some individuals. We would, however, like to offer a note of caution. While the operating premise of Dr Pulido et al is valid and their analysis is appropriate, it should be noted that any recommendation concerning drug toxicity to the retina obtained from animal experiments is a rough estimate. Species differences are likely to be more important sources of uncertainty in determining safe and toxic doses than are methods of data analysis. Trivial differences
Lagrangian Analysis and Prediction of Coastal and Ocean Dynamics (2007)

Written by a group of international experts in their field, this book is a review of Lagrangian observation, analysis and assimilation methods in physical and biological oceanography. This multidisciplinary text presents new results on nonlinear analysis of Lagrangian dynamics, the prediction of particle trajectories, and Lagrangian stochastic models. It includes historical information, up-to-date developments, and speculation on future developments in Lagrangian-based observations, analysis, and modeling of physical and biological systems. Containing contributions from experimentalists, theoreticians, and modellers in the fields of physical oceanography, marine biology, mathematics, and meteorology, this book will be of great interest to researchers and graduate students looking for both practical applications and information on the theory of transport and dispersion in physical systems, biological modelling, and data assimilation.
Dynamic Recrystallization of a Commercial Cu-Be-Co Alloy during Hot Deformation (1993)

Hot deformation as well as dynamic recrystallization (DRX) of a commercial Cu-Be25(Cu-1.8Be-0.25Co) alloy were studied by means of tensile testing and microstructural observation at the temperature ranging 923 K to 1123 K under strain rates of 10−5 to 10−1 s−1. The flow curves showed a sharp yield point phenomenon followed by work softening and steady state flow at higher Z (=\dotεexp(Q⁄RT)), although they showed normal yielding, work hardening and then steady state flow at lower Z. DRX took place during work softening or hardening and led to an equilibrium or stable grain structure at high strains. The stable structure, which was dependent on T or \dotε, consisted of a mixture of fine grains and comparatively coarse grains with many sided irregular boundaries at higher Z. In contrast, almost equiaxial grains with smooth or straight boundaries were observed at lower Z. A relationship between the steady state flow stress σs and the stable dynamic grain size Ds is almost the same as that of Cu at higher Z, but it shifted towards a finer grain side at lower Z. Such different types of DRX are discussed by considering the roles of alloying elements of Be and Co. It is concluded that yielding flow can be controlled by the viscous motion of dislocations which drag the solute atmosphere composed of Be atoms, and on the other hand, steady state flow can be controlled by DRX assisted by the volume diffusion of Cu atoms.
Strategies to stabilize exohedral η 5 - and η 6 -fullerene transition metal organometallic complexes: a molecular orbital treatment (1999)

Transition metal fragments are designed to overcome the unfavourable interaction arising from the splayed-out π-orbitals of the five-and six-membered rings of C60 in complex formation. Semiemprical studies at the PM3(tm) level on a series of C60MCnHn complexes suggest that, with the appropriate transition metal fragment, it is possible to stabilize η6-complexes of C60. Isodesmic equations of the type CmHmMCnHn + C60→ C60MCnHn + CmHm indicate that C3H3Co and C3H3Rh are ideal fragments in stabilizing η6-C60 complexes. In comparison, η5-complexes are less favourable; structural modifications such as those in the recently synthesized C60Ph5- should readily help η5-bonding.
Investigating the Alteration of Sandstone Pore System and Rock Features by Role of Weighting Materials (2021)

Drilled formations are commonly invaded by drilling fluids during the drilling operations, and as a result, the rock pore system will have alterations that consequently alter the rock properties. The objective of this study is to investigate the impact of the most commonly used weighting materials in water-based mud (WBM) on the Berea Buff sandstone pore system and rock characteristics. Rock-mud interaction was imposed by using a customized high-pressure high-temperature filtration test cell under 300 psi differential pressure and 200 °F temperature to simulate downhole conditions during drilling that affect the rock-mud interaction. Extensive lab analysis was accomplished to investigate the rock characteristic alterations in terms of rock porosity, permeability, pore size distribution, flow characteristics, resistivity, and acoustic properties. Ilmenite-WBM showed the maximum values (8.3 cm<sup>3</sup> filtrate volume and 7.6 mm cake thickness), while barite recorded the lowest filtrate volume (5.3 cm<sup>3</sup>) and thickness (3 mm). Nuclear magnetic resonance profiles illustrated the changes in the rock pore system due to the dominant precipitation or dissolution effects. A general porosity reduction was recorded with all mud types that ranged from 4.2 to 9.9% for ilmenite and Micromax, respectively. The rock permeability showed severe damage after mud exposure and a reduction in the pore throat radius. After mud invasion, the rock electrical resistivity showed alterations based on the mineralogical composition of the weighting materials that replaced the saturated brine from the rock pores. Compressional wave velocities (<i>V</i> <sub>p</sub>) showed an increasing trend as <i>V</i> <sub>p</sub> of Micromax-WBM increased by 4.5%, while hematite- and ilmenite-WBMs recorded the minimum increase of 1.8%. A general reduction was found for shear wave velocities (<i>V</i> <sub>s</sub>); Micromax-WBM showed the highest <i>V</i> <sub>s</sub> reduction by 6.6%, while ilmenite-WBM recorded the minimum reduction of 1.8%. The pore system alterations are the main reason behind <i>V</i> <sub>p</sub> increase, where the rock lithology alterations controlled the <i>V</i> <sub>s</sub> changes. The study findings will add more for the rock logging interpretation and rock properties alterations after the mud exposure.
Insulin-Ricin B Chain Conjugate Has Enhanced Biological Activity in Insulin-Insensitive Cells* (1983)

Insulin-ricin B chain conjugate, a hybrid molecule consisting of insulin covalently linked to the binding chain of ricin, was tested for insulin-like biological activity in HTC and H35 rat hepatoma cells, rat adipocytes, rat thymocytes, and human fibroblasts. In H35 cells and adipocytes, cells that have abundant insulin receptors and are very sensitive to insulin (ED50 of 30 pM and 50 pM, respectively), the conjugate had 5% the biological activity of native insulin (ED50 of 500 pM and 1000 pM, respectively). Since the insulin portion of the conjugate has 5% the potency of native insulin in binding to the insulin receptor, these observations suggested that (in these cells) the conjugate was acting via the insulin receptor. Moreover lactose and galactose, potent inhibitors of ricin binding to its receptor, had no effect on the action of the conjugate on H35 cells. In contrast, in thymocytes, HTC cells, and fibroblasts cells that have relatively few insulin receptors and require high concentrations of insulin to elicit biological actions (ED50 of 10 nM, 20 nM, and 1 nM, respectively), the conjugate had more biological activity than was predicted on the basis of its ability to bind to the insulin receptor. In addition, in these three insulin-insensitive cell types, the activity of the conjugate was inhibited by either lactose or galactose. Thus, these observations indicate that in cells which are relatively insensitive to insulin, the biological effects of the conjugate require the interaction of the ricin B chain moiety with the ricin receptor. In addition, in fibroblasts, the activity of the conjugate was inhibited by the addition of a monoclonal antibody to the insulin receptor which inhibits the response of fibroblasts to insulin. These data suggest, therefore, that in insulin-insensitive cells the binding of the ricin B chain moiety to its receptor enhances the interaction of the insulin portion of the conjugate with the insulin receptor.
Modulation of lnterleukin-2-Driven Proliferation of Human Large Granular Lymphocytes by Carbaryl, an Anticholinesterase Insecticide (1991)

Modulation of Interieukin-2-Driven Proliferation of Human Large Granular Lymphocytes by Carbaryl, an Anticholinesterase Insecticide. Bavari, S., Casale, G. P., Gold, R. E., and Vitzthum, E. F. (1991). Fundam. Appl. Toxicol. 17,61-74. Studies in other laboratories have provided evidence that the interleukin-2 (IL2) signaling pathway in lymphocytes includes essential, serine proteases. Since the anticholinesterase (antiCHE) insecticides are potent serine hydrolase (esterase and protease) inhibitors, we assessed the ability of carbaryl (CA, a widely used antiCHE insecticide) and a-naphthol (NA, a major metabolite of carbaryl) to modulate IL2-driven proliferation of large granular lymphocytes (LGL) purified from human peripheral blood. These cells express nearly all of the natural killer (NK.) activity of human peripheral Wood. NK cells are normal lymphocytes that respond to IL2 by proliferating and increasing their tumoricidal activity on a per cell basis. Cultures of purified LGL, initiated in the presence of human recombinant IL2, were harvested on culture Day 4, then proliferation was measured as [3H]thymidine incorporation. When added only at the time cultures were initiated, CA inhibited incorporation 10-32%, 35-53%, and 54-57% at 0.5, 5.0, and 50 mm, respectively. In contrast, NA had no effect at 0.5 and 5.0 mm, but was inhibitory (16-17%) at 50 mm. Reexposure to CA or NA, during the incorporation assay, had little effect on the observed inhibition profiles. Chemically induced changes in cell number during an 8-day culture period reflected the chemically induced changes in [3H]thymidine incorporation. Neither CA nor NA produced cell death. Quantitation of both CA and NA by HPLC indicated a rapid loss of CA (ca. 95% in 24 hr) and a much slower loss of NA from the culture medium. CA inhibited human LGL proliferation at concentrations producing little or no inhibition of serum CHE, an indicator of exposure to antiCHE insecticides.
Chromium-Catalyzed Intramolecular Enyne Metathesis (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromium-Catalyzed Intramolecular Enyne MetathesisSusumu Watanuki, Nagisa Ochifuji, and Miwako MoriCite this: Organometallics 1995, 14, 11, 5062–5067Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/om00011a027https://doi.org/10.1021/om00011a027research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3D Flame Measurements at 5 kHz on a Jet Fueled Aviation Combustor (2015)

This paper describes the measurements of three-dimensional (3D) flame measurements at 5 kHz from an optically accessible, atmospheric combustor burning Jet A. The measurements were performed by 3D tomography of flame chemiluminescence emissions. Such measurements resolve the instantaneous flame topography generated by the combustor in all three spatial directions and at a temporal resolution of 5 kHz (0.2 ms), essentially providing 4D information about the combustor. This paper reports the measurement technique, the experimental implementation, the results and their expected use for the continued development of future combustor concepts.
Fundamental Use of Surgical Energy (FUSE) (2015)

In Brief Traditional medical education curricula for students, residents, and trainees do not address the rapidly growing number of technological devices that are fundamentally changing health care delivery today, exposing both operators and patients to increasing risk for injury. The gap in adequate education and training prompted the development of the Fundamental Use of Surgical Energy (FUSE) program. The FUSE program and future educational curricula represent a necessary paradigm shift in traditional medical education.
for Casimir Forces in Chiral Metamaterials (2010)

Department of Mathematics, Massachusetts Institute of Technology, Cambridge MA 02139, USA(Dated: June 30, 2010)We examine a recent prediction for the chirality-dependence of the Casimir force in chiral meta-materials by numerical computation of the forces between the exact microstructures, rather thanhomogeneous approximations. We compute the exact force for a chiral bent-cross pattern, as well asforces for an idealized \omega-particle medium in the dilute approximation and identify the e ectsof structural inhomogeneity (i.e. proximity forces and anisotropy). We nd that these microstructuree ects dominate the force for separations where chirality was predicted to have a strong inuence.To get observations of chirality free from microstructure e ects, one must go to large separationswhere the e ect of chirality is at most ˘10
Designing a nanoantenna-superlens system for sensing applications (2012)

We demonstrate near field enhancement generation in a silver nanoantenna-superlens system. Using near-field coupling effect and genetic algorithm for optimization we can design a nanoantenna-superlens system with mismatched permittivities for sensing applications.
5,5′-Methylenebis[6-amino-3-methyl-2-methylsulfanylpyrimidin-4(3H)-one]: an unusual molecular geometry within a hydrogen-bonded molecular ribbon (2013)

The molecules of the title compound, C13H18N6O2S2, lie across twofold rotation axes in the space group C2/c. Although the pyrimidine ring is effectively planar, the bridging methylene C atom is displaced from the plane of the pyrimidine ring by 0.213 (2) Å, while the C-C-C angle at the bridging C atom is 120.3 (2)°. The molecule contains two symmetry-related N-H···O hydrogen bonds, generating S(8) motifs, and intermoecular N-H···O hydrogen bonds link the molecules into a ribbon of edge-fused rings.
Multicenter study of comparative outcomes of hematopoietic stem cell transplant for peripheral T cell lymphoma and natural killer/T-cell lymphoma (2011)

10.3109/10428194.2011.569038
Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics (2014)

Cancer is a complex disease; glioblastoma (GBM) is no exception. Short survival, poor prognosis, and very limited treatment options make it imperative to unravel the disease pathophysiology. The critically important identification of proteins that mediate various cellular events during disease is made possible with advancements in mass spectrometry (MS)-based proteomics. The objective of our study is to identify and characterize proteins that are differentially expressed in GBM to better understand their interactions and functions that lead to the disease condition. Further identification of upstream regulators will provide new potential therapeutic targets. We analyzed GBM tumors by SDS-PAGE fractionation with internal DNA markers followed by liquid chromatography-tandem mass spectrometry (MS). Brain tissue specimens obtained for clinical purposes during epilepsy surgeries were used as controls, and the quantification of MS data was performed by label-free spectral counting. The differentially expressed proteins were further characterized by Ingenuity Pathway Analysis (IPA) to identify protein interactions, functions, and upstream regulators. Our study identified several important proteins that are involved in GBM progression. The IPA revealed glioma activation with z score 2.236 during unbiased core analysis. Upstream regulators STAT3 and SP1 were activated and CTNNα was inhibited. We verified overexpression of several proteins by immunoblot to complement the MS data. This work represents an important step towards the identification of GBM biomarkers, which could open avenues to identify therapeutic targets for better treatment of GBM patients. The workflow developed represents a powerful and efficient method to identify biomarkers in GBM.