gebhart/patrepeval huggingface dataset:
Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. (1993)

To determine the effects of acute myocardial infarction on the regulation of angiotensin II (Ang II) receptors and contractile performance of left and right ventricular myocytes, coronary artery ligation was surgically induced in rats, and Ang II receptor density and affinity and the mechanical properties of surviving muscle cells were examined 1 week later. Physiological determinations of cardiac pump function revealed the presence of ventricular failure, which was associated at the cellular level with a depression in the velocity of myocyte shortening and relengthening, a prolongation of time to peak shortening, and a reduction in the extent of cell shortening. These abnormalities in single-cell function were more prominent in left than in right ventricular myocytes. Cellular hypertrophy was documented by increases in cell length and width, which were also greater in the spared myocytes of the infarcted left ventricle. Reactive hypertrophy was accompanied by a 1.84- and 1.85-fold increase in the density of Ang II receptors on left and right myocytes, respectively. On the other hand, the affinity of Ang II receptors for the radiolabeled antagonist was not altered. However, Ang II-stimulated phosphoinositol turnover was enhanced by 3.7- and 2.5-fold in left and right myocytes, respectively, after infarction. Ventricular myocytes were found to possess the AT1 receptor subtype exclusively. In conclusion, myocardial infarction leads to impairment in the contractile behavior of the remaining cells and to the activation of Ang II receptors and effector pathway associated with these receptors, which may be involved in the reactive growth adaptation of the viable myocytes.
Sedation-analgesia with propofol and remifentanil : new model for individualized BIS prediction (2011)

Sedation-analgesia with propofol and remifentanil : new model for individualized BIS prediction
The capacity of a class of broadcast channels (1979)

The capacity region is established for those discrete memoryless broadcast channels <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p(y,z \mid x)</tex> for which <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I(X;Y) \geq I(X;Z)</tex> holds for all Input distributions. The capacity region for this class of channels resembles the capacity region for degraded message sets considered by Körner and Marton.
Software-Defined Cloud Computing: Architectural Elements and Open\n Challenges (2014)

The variety of existing cloud services creates a challenge for service\nproviders to enforce reasonable Software Level Agreements (SLA) stating the\nQuality of Service (QoS) and penalties in case QoS is not achieved. To avoid\nsuch penalties at the same time that the infrastructure operates with minimum\nenergy and resource wastage, constant monitoring and adaptation of the\ninfrastructure is needed. We refer to Software-Defined Cloud Computing, or\nsimply Software-Defined Clouds (SDC), as an approach for automating the process\nof optimal cloud configuration by extending virtualization concept to all\nresources in a data center. An SDC enables easy reconfiguration and adaptation\nof physical resources in a cloud infrastructure, to better accommodate the\ndemand on QoS through a software that can describe and manage various aspects\ncomprising the cloud environment. In this paper, we present an architecture for\nSDCs on data centers with emphasis on mobile cloud applications. We present an\nevaluation, showcasing the potential of SDC in two use cases-QoS-aware\nbandwidth allocation and bandwidth-aware, energy-efficient VM placement-and\ndiscuss the research challenges and opportunities in this emerging area.\n
Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications (2019)

Cystic fibrosis (CF) is a complex, potentially life-threatening disease that is most effectively treated through the administration of antibiotics (e.g., colistimethate sodium). Chronic infection with <i>Pseudomonas aeruginosa</i> is one of the most significant events in the pathogenesis of cystic fibrosis, and tobramycin is the treatment of choice for those patients with chronic <i>P. aeruginosa</i> infection who are deteriorating despite regular administration of colistimethate sodium. Effective treatment can be challenging due to the accumulation of thickened mucus in the pulmonary environment, and here we describe the results of our investigation into the development of alginate/chitosan particles prepared via precipitation for such environments. Tobramycin loading and release from the alginate/chitosan particles was investigated, with evidence of both uptake and release of sufficient tobramycin to inhibit <i>P. aeruginosa</i> in vitro. Functionalisation of the alginate/chitosan particles with secretory leukocyte protease inhibitor (SLPI) was shown to help inhibit the inflammatory response associated with lung infections (via inhibition of neutrophil elastase activity) and enhance their interaction with cystic fibrosis mucus (assayed via reduction of the depth of particle penetration into the mucus) in vitro, which have prospects to enhance their efficacy in vivo.
Somatically generated mouse myeloma variants synthesizing IgA half-molecules. (1981)

Whereas mouse myelomas that secrete IgA half-molecules have been shown to arise in vivo, their origin has not been definitely established. We show that somatic variants secreting phenotypically similar molecules can arise directly from the normal IgA-secreting myelomas S107 and W3082. In addition to being improperly assembled, the variant proteins have distinct carboxy-terminal deletions and an aberrant heavy-light chain disulfide bond. For at least one of the variants, variable region serology and affinity for hapten are both unaffected by these changes. Southern and Northern blot analyses indicate normal size DNA restriction fragments and mRNA, suggesting premature termination as the mechanism of deletion. These results are discussed in relation to possible mutational hot spots and long-range interdomain interactions.
Reliable 4H-SiC MOSFET with High Threshold Voltage by Al<sub>2</sub>O<sub>3</sub>-Inserted Gate Insulator (2015)

We investigated the effect of an Al 2 O 3 insertion layer in the gate insulator to make V th higher and to improve the transconductance G m in a SiC-MOSFET. Insertion of the Al 2 O 3 layer successfully enlarged Vth by about 4 V. The Vth difference sub-threshold Id-Vg characteristics measured by sweeping the gate voltage bi-directionally indicates that insertion of the Al 2 O 3 layer decreased the number of traps of electrons in the gate insulator. Due to this decrease, device reliability in long-term operation was improveed by smaller Vth shift in PBTI. It was also found that the insertion of the Al 2 O 3 layer improved G m by two times. Using this gate insulator, we succeeded in fabricating 600 V 20 A-class vertical SiC DMOSFETs with a high Vth (&gt;5 V) and low Ron of 3 mΩcm 2 .
A 4.7 T/11.1 T NMR Compliant 50 nW Wirelessly Programmable Implant for Bioartificial Pancreas In Vivo Monitoring (2016)

This paper presents a 50 nW wirelessly powered implant for the noninvasive monitoring of a bioartificial pancreas postimplantation in nuclear magnetic resonance (NMR) animal studies. The proposed implant increases NMR signal sensitivity across a 190-470 MHz frequency range in both 4.7 and 11.1 T magnetic fields through the use of a wirelessly programmable resonator. An integrated split capacitive array provides 51.8 pF tuning range and 52 fF resolution while maintaining resonant Q and reducing parasitic contributions. The implant supports forward data telemetry at 5-250 kbit/s using an envelope detector front-end and a 2.4 MHz oversampling clock/data recovery (CDR) receiver. An integrated logic-controlled RF-DC converter and strongly coupled resonant wireless link provide sustained reliable energy transfer during NMR acquisition. NMR signal isolation from the wireless power transmissions is achieved through frequency allocation and orthogonally embedded coil design that provides increased mechanical strength for incorporating device components. Experimental results in tissue-equivalent gel phantoms and small animal studies show an increase in acquired signal-to-noise ratio (SNR) by 141% (7.7 dB) and 83% (5.3 dB) within 4.7 and 11.1 T magnetic field strengths, respectively, with an approximate 100% (6 dB) increase in SNR within the region of interest (ROI) at higher image resolutions.
Hydraulic clutch modeling for automotive control (2013)

A low-order dynamic model of a clutch for hydraulic control in an automatic transmission is developed by separating dynamics of the shift into four regions based on clutch piston position. The first three regions of the shift are captured by a physics-based model and the fourth region is represented by a system identification model. These models are determined using nominal values and validated against nominal and off-nominal experimental data. The model provides two lumped flow parameters to be used for tuning to the desired hydraulic clutch system.
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases (2013)

The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase. Recent work suggests they play important roles in regulating key biological processes including Myc-driven tumorigenesis, senescence, cell adhesion and neuronal polarity. In the present paper we describe the first highly specific protein kinase inhibitors of NUAK kinases namely WZ4003 and HTH-01-015. WZ4003 inhibits both NUAK isoforms (IC50 for NUAK1 is 20 nM and for NUAK2 is 100 nM), whereas HTH-01-015 inhibits only NUAK1 (IC50 is 100 nM). These compounds display extreme selectivity and do not significantly inhibit the activity of 139 other kinases that were tested including ten AMPK family members. In all cell lines tested, WZ4003 and HTH-01-015 inhibit the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser(445). We also identify a mutation (A195T) that does not affect basal NUAK1 activity, but renders it ~50-fold resistant to both WZ4003 and HTH-01-015. Consistent with NUAK1 mediating the phosphorylation of MYPT1 we find that in cells overexpressing drug-resistant NUAK1[A195T], but not wild-type NUAK1, phosphorylation of MYPT1 at Ser(445) is no longer suppressed by WZ4003 or HTH-01-015. We also demonstrate that administration of WZ4003 and HTH-01-015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound-healing assay to a similar extent as NUAK1-knockout. WZ4003 and HTH-01-015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout and U2OS cells to the same extent as NUAK1 shRNA knockdown. We find that WZ4003 and HTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. The results of the present study indicate that WZ4003 and HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases.
Multifocal Electroretinography as a Function of Age: The Importance of Normative Values for Older Adults (2003)

The age-associated mfERG alterations are presented to emphasize the importance of appropriate normative data in interpretation of mfERGs.
A quantitative method for assessing smoke associated molecular damage in lung cancers (2018)

We have established and validated a quantitative assay that will be of use in assessing the presence and degree of smoke associated molecular damage in lung cancers arising in ever and never smokers.
Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes (2009)

The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter flow cytometry (FCM) in the diagnosis and prognostication of myelodysplastic syndromes. In March 2008, representatives from 18 European institutes participated in a European LeukemiaNet (ELN) workshop held in Amsterdam as a first step towards standardization of FCM in myelodysplastic syndromes. Consensus was reached regarding standard methods for cell sampling, handling and processing. The group also defined minimal combinations of antibodies to analyze aberrant immunophenotypes and thus dysplasia. Examples are altered numbers of CD34(+) precursors, aberrant expression of markers on myeloblasts, maturing myeloid cells, monocytes or erythroid precursors and the expression of lineage infidelity markers. When applied in practice, aberrant FCM patterns correlate well with morphology, the subclassification of myelodysplastic syndromes, and prognostic scoring systems. However, the group also concluded that despite strong evidence for an impact of FCM in myelodysplastic syndromes, further (prospective) validation of markers and immunophenotypic patterns are required against control patient groups as well as further standardization in multi-center studies. Standardization of FCM in myelodysplastic syndromes may thus contribute to improved diagnosis and prognostication of myelodysplastic syndromes in the future.
Alternative Splicing of MR1 regulates antigen presentation to MAIT cells (2019)

Abstract Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These cells are activated upon encountering microbial antigen(s) displayed by MR1 on the surface of an infected cell. Human MR1 undergoes alternative splicing. The full length isoform, MR1A, can activate MAIT cells, while the function of the isoforms, MR1B and MR1C, are not well characterized. In this report, we sought to characterize these splice variants. Using a transcriptomic analysis in conjunction with qPCR, we find that that MR1A and MR1B transcripts are widely expressed. Despite the widespread expression of MR1A and MR1B, only MR1A can present mycobacterial antigen to MAIT cells. Coexpression of MR1B with MR1A serves to decrease MAIT cell activation following bacterial infection. However, expression of MR1B prior to MR1A lowers total MR1A abundance, suggesting competition between MR1A and MR1B for either ligands or chaperones required for folding and/or trafficking. Finally, we evaluated CD4/CD8 double positive thymocytes expressing surface MR1. Relative MR1A/MR1B expression in MR1-expressing thymocytes is associated with their prevalence. Our results suggest alternative splicing of MR1 represents a means of regulating MAIT activation in response to microbial ligand. Funding This work was supported by NIH T32HL083808 (EK, GAN, EM), VA Merit Award I01CX001562 (MJH), NIH R01AI29976 (MJH), NIH R01AI048090 (DML), NIH R21AI124225-01A1 (FT) and VA Merit Award I01BX000533 (DML). The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.
Carbon nanotube thin film transistors based on aerosol methods (2009)

We demonstrate a fabrication method for high-performance field-effect transistors (FETs) based on dry-processed random single-walled carbon nanotube networks (CNTNs) deposited at room temperature. This method is an advantageous alternative to solution-processed and direct CVD grown CNTN FETs, which allows using various substrate materials, including heat-intolerant plastic substrates, and enables an efficient, density-controlled, scalable deposition of as-produced single-walled CNTNs on the substrate directly from the aerosol (floating catalyst) synthesis reactor. Two types of thin film transistor (TFT) structures were fabricated to evaluate the FET performance of dry-processed CNTNs: bottom-gate transistors on Si/SiO2 substrates and top-gate transistors on polymer substrates. Devices exhibited on/off ratios up to 10(5) and field-effect mobilities up to 4 cm(2) V(-1) s(-1). The suppression of hysteresis in the bottom-gate device transfer characteristics by means of thermal treatment in vacuum and passivation by an atomic layer deposited Al(2)O(3) film was investigated. A 32 nm thick Al(2)O(3) layer was found to be able to eliminate the hysteresis.
Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer (2017)

Thyroid cancer is the most common cancer in Korea. Several susceptibility loci of differentiated thyroid cancer (DTC) were identified by previous genome-wide association studies (GWASs) in Europeans only. Here we conducted a GWAS and a replication study in Koreans using a total of 1,085 DTC cases and 8,884 controls, and validated these results using expression quantitative trait loci (eQTL) analysis and clinical phenotypes. The most robust associations were observed in the NRG1 gene (rs6996585, P=1.08 × 10<sup>-10</sup>) and this SNP was also associated with NRG1 expression in thyroid tissues. In addition, we confirmed three previously reported loci (FOXE1, NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SEPT11 and SLC24A6) associated with DTC. Furthermore, we identified specific variants of DTC that have different effects according to cancer type or ethnicity. Our findings provide deeper insight into the genetic contribution to thyroid cancer in different populations.
Intersubband semiconductor lasers without population inversion (1995)

We propose a new class of intersubband lasers and amplifiers that achieve net gain without population inversion, as well as parametric amplifiers that realize resonantly enhanced χ(2) without absorption. Gain calculations and data from emission and absorption measurements on unipolar double-quantum-well structures are presented.
Supplementary Figure 2 from Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480 (2023)

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Micro- and mesoporous carbide-derived carbon prepared by a sacrificial template method in high performance lithium sulfur battery cathodes (2014)

Hierarchical micro- and mesoporous CDC materials prepared by sacrificial templating with high performance in lithium–sulfur battery cathodes are presented.
GR-2397: Review of the Novel Siderophore-like Antifungal Agent for the Treatment of Invasive Aspergillosis (2022)

GR-2397 (previously VL-2397, ASP2397) is a first-in-class antifungal agent for the treatment of invasive aspergillosis. This siderophore-like molecule resembles ferrichrome; however, it is differentiated by three amino acid changes and an aluminum rather than iron chelate. GR-2397 is transported into fungal cells via the Sit1 transporter, which is not found in humans, leading to fungal specificity. Although the precise mechanism of action is currently unknown, GR-2397 is active against <i>Aspergillus</i> spp. including azole-resistant strains, <i>Fusarium solani</i>, and <i>Candida glabrata</i> in addition to other organisms. Efficacy has been demonstrated in several animal models of invasive aspergillosis, including a 24 h delayed-treatment model where rapid fungicidal activity was observed. Phase 1 single- and multiple-ascending intravenous dose studies showed that GR-2397 was safe and well-tolerated in humans. No signs of GR-2397 accumulation were observed following IV infusions of 300, 600, and 1200 mg every 24 h (q24h) for 7 days. The favorable safety, tolerability and drug-drug interaction profile, along with good tissue distribution, support further development of GR-2397 as a new treatment option for patients with invasive aspergillosis. This systematic review summarizes the published findings of GR-2397.
A new E-O focusing lens for higher-density optical disks (1992)

We describe a new electro-optic focusing lens using PLZT as a fine focus adjustment for an SHG green laser optical disk pickup system.
BIOEFFICACY OF CRUDE AND FRACTIONS OF ARGEMONE MEXICANA AGAINST TOBACCO CATERPILLAR, SPODOPTERA LITURA FAB. (NOCTUIDAE: LEPIDOPTERA) (2008)

The insecticidal activity of crude extracts and fractions of Argemone mexicana L. (Papaveraceae)was investigated against Spodoptera litura Fab. (Noctuidae: Lepidoptera). The different treatments differed significantly in their efficacy. Pupation was nil in chloroform extract and acetone extract, while water extract treated larvae resulted in least pupal weight and maximum malformed adults. The adult life span was least in acetone solvent followed by hexane and petroleum ether extracts. Most of the treatments resulted in nil fecundity. Among the chloroform fractions, the first fraction arrested the pupation. In addition, disturbed moulting, larval-pupal intermediates and malformed moth emergence/dead pupae were also observed.
Micellar structure and mechanical properties of block copolymer‐modified epoxies (2001)

Abstract Amphiphilic block copolymers provide a unique means for toughening epoxy resins because they can self‐assemble into different inclusion shapes before epoxy curing. The two examples reported here are spherical micelles and vesicles, which form in blends containing epoxy and symmetric or asymmetric poly(ethylene oxide)–poly(ethylene‐ alt ‐propylene) (PEO–PEP) block copolymer with PEO volume fractions of 0.5 and 0.26, respectively. The vesicles and spherical micelles were characterized by transmission electron microscopy and small‐angle X‐ray scattering (SAXS), respectively. SAXS data from the spherical micelles were fit to the Percus–Yevick model for a liquid‐like packing of spheres with hard‐core interactions. Mechanical properties of spherical‐micelle‐modified and vesicle‐modified epoxies in the dilute limit are compared. The glass‐transition temperature and Young's (storage) modulus were tested with dynamic mechanical spectroscopy, and compact‐tension experiments were performed to determine the critical plane‐strain energy release rate for fracture. Vesicles were most effective in improving the epoxy fracture resistance. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part B: Polym Phys 39: 2996–3010, 2001