gebhart/patrepeval huggingface dataset:
The histone deacetylase-3 complex contains nuclear receptor corepressors (2000)

Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase (HDAC) enzymes have been identified to date. The class I deacetylases HDAC1 and HDAC2 are components of multisubunit complexes, one of which could associate with the nuclear hormone receptor corepressor, N-CoR. N-CoR also interacts with class II deacetylases HDAC4, HDAC5, and HDAC7. In comparison with HDAC1 and HDAC2, HDAC3 remains relatively uncharacterized, and very few proteins have been shown to interact with HDAC3. Using an affinity purification approach, we isolated an enzymatically active HDAC3 complex that contained members of the nuclear receptor corepressor family. Deletion analysis of N-CoR revealed that HDAC3 binds multiple N-CoR regions in vitro and that all of these regions are required for maximal binding in vivo. The N-CoR domains that interact with HDAC3 are distinct from those that bind other HDACs. Transient overexpression of HDAC3 and microinjection of Abs against HDAC3 showed that a component of transcriptional repression mediated by N-CoR depends on HDAC3. Interestingly, data suggest that interaction with a region of N-CoR augments the deacetylase activity of HDAC3. These results provide a possible molecular mechanism for HDAC3 regulation and argue that N-CoR is a platform in which distinct domains can interact with most of the known HDACs.
Fabrication of 4 × 1 signal combiner for high-power lasers using hydrofluoric acid (2018)

We report a new method to fabricate a 4 × 1 signal combiner that comprises an output fiber port and a tapered fused bundle (TFB) with four input fiber ports. The TFB is etched in a solution of hydrofluoric acid and spliced with an output fiber of core diameter 105 μm and cladding diameter 125 μm. Each cladding of the four input optical fiber is etched to approximately 72.5 μm. The etched TFB was fabricated by tapering after forming a bundle of four etched optical fibers. Subsequently, the 4 × 1 signal combiner is fabricated by fusion splicing between the fabricated TFB and output optical fiber with a numerical aperture of 0.15. The efficiency of each port of the fabricated 4 × 1 signal combiner is in the range of 93.3-98.3%. When an optical power of approximately 624.5 W was input to the signal combiner, the maximum output was ~612 W and the efficiency was ~98%. The beam quality factor, M 2is measured to be approximately 14.6, which is calculated as the beam parameter product (BPP) of 5.02 mm·mrad.
Divergent Patterns of Colonization and Immune Response Elicited from Two IntestinalLactobacillusStrains That Display Similar Properties In Vitro (2002)

Lactobacilli derived from the endogenous flora of normal donors are being increasingly used as probiotics in functional foods and as vaccine carriers. However, a variety of studies done with distinct strains of lactobacilli has suggested heterogeneous and strain-specific effects. To dissect this heterogeneity at the immunological level, we selected two strains of lactobacilli that displayed similar properties in vitro and studied their impact on mucosal and systemic B-cell responses in monoxenic mice. Germfree mice were colonized with Lactobacillus johnsonii (NCC 533) or Lactobacillus paracasei (NCC 2461). Bacterial loads were monitored for 30 days in intestinal tissues, and mucosal and systemic B-cell responses were measured. Although both Lactobacillus strains displayed similar growth, survival, and adherence properties in vitro, they colonized the intestinal lumen and translocated into mucosal lymphoid organs at different densities. L. johnsonii colonized the intestine very efficiently at high levels, whereas the number of L. paracasei decreased rapidly and it colonized at low levels. We determined whether this difference in colonization correlated with an induction of different types of immune responses. We observed that colonization with either strain induced similar germinal center formation and immunoglobulin A-bearing lymphocytes in the mucosa, suggesting that both strains were able to activate mucosal B-cell responses. However, clear differences in patterns of immunoglobulins were observed between the two strains in the mucosa and in the periphery. Therefore, despite similar in vitro probiotic properties, distinct Lactobacillus strains may colonize the gut differently and generate divergent immune responses.
Wnt10b and Dkk-1 gene therapy differentially influenced trabecular bone architecture, soft tissue integrity, and osteophytosis in a skeletally mature rat model of osteoarthritis (2016)

The Wnt-inhibitor Dkk-1 does not appear to completely inhibit the effects of Wnt signaling on bone remodeling. In vivo upregulation of Wnt10b and its inhibitor, Dkk-1, can produce both parallel or contrasting phenotypic responses depending on the specific parameter measured and the fidelity of the examined joint. These observations elucidate different roles for Wnt signaling in stable versus destabilized joints and may help to explain the conflicting results previously reported for the role of Dkk-1 in joint disease.
Comparative modelling of differential through‐silicon vias up to 40 GHz (2013)

The three‐dimensional integrated circuit has attracted considerable attention because of the evolving functions of today's integrated circuit products and a continuing demand for reduced power consumption and miniature chip size. Through‐silicon vias (TSVs) provide a vertical interconnection between stacked dies; they are much shorter and have a denser connectivity than the hybrid horizontal and bondwire interconnects in conventional use. Differential interconnects are more commonly used in high‐speed digital circuits rather than single‐ended ones because of their higher immunity to common‐mode noise. Accordingly, presented is a scalable physical model for differential TSVs. Mixed‐mode S ‐parameters were generated using the established model and the electrical performance of a GSSG‐type differential TSV was compared with that of a GSGSG‐type differential TSV. Furthermore, four‐port S ‐parameters were measured up to 40 GHz to validate the modelled results.
Initial experience establishing an EUV baseline lithography process for manufacturability assessment (2007)

The International Venture for Nanolithography (INVENT) initiative announced in mid 2005, a unique industry-university consortium between the College of Nanoscale Science and Engineering at Albany and a group of leading edge integrated device manufacturers, has launched an extensive R&D program on EUV lithography (EUVL). The overall scope of the INVENT EUVL program, the status of our efforts to establish a baseline lithography process on a full-field EUVL scanner, and our progress in evaluating EUV resist materials, in designing a custom reticle for scanner characterization and in developing an actinic EUV mask imaging microscope, are discussed.
The Role of Influenza A Virus Hemagglutinin Residues 226 and 228 in Receptor Specificity and Host Range Restriction (1998)

Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza viruses do not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino acids at positions 226 and 228 of hemagglutinin (HA) of the H3 subtype are known to be important for this host range restriction, the contributions of specific amino acids at these positions to restriction were not known. Here, we address this issue by generating HAs with site-specific mutations of a human virus that contain different amino acid residues at these positions. We also let ducks select replication-competent viruses from a replication-incompetent virus containing a human virus HA by inoculating animals with 10(10.5) 50% egg infectious dose of the latter virus and identified a mutation in the HA. Our results showed that the Ser-to-Gly mutation at position 228, in addition to the Leu-to-Gln mutation at position 226 of the HA of the H3 subtype, is critical for human virus HA to support virus replication in duck intestine.
Secretory component: a glandular epithelial cell marker. (1981)

Secretory component (SC) has been demonstrated to be produced by both normal and malignantly transformed glandular epithelial cells. By an indirect immunofluorescent technique, this study surveys tumors of varied cellular origin in order to determine the reliability of SC as a marker for tumor cells derived from glandular epithelium. Both primary and metastatic tumors of glandular epithelial origin demonstrated SC fluorescence, while nonglandular epithelial tumors did not. This observation was extended to live single-cell preparations, which demonstrated intense cell-surface fluorescence only when glandular epithelial tumors cells were examined. Additionally, fixed, cytocentrifuged, single-cell preparations of glandular epithelial tumors demonstrated cytoplasmic SC fluorescence. When breast carcinoma was examined, all cases demonstrated SC, regardless of the degree of differentiation. This assay appears to have useful clinical application in that the finding of SC provides indication of the glandular epithelial origin of a malignantly transformed cell.
Semiconductor wafer printing simulation by digital apodization of high-resolution actinic photomask images (2003)

Aerial images formed by exposure tool simulation microscopes provide valuable information in determining the printability of photomask patterns prior to actual photoresist exposure. Exact simulation of production-grade step-and-scan exposure tools generally requires a complex optical system. This paper describes an accurate aerial imaging simulation technique using a relatively simple actinic, high-resolution inspection microscope incorporating image processing software. A high-resolution aerial image is captured by the inspection tool's CCD camera. The photomask spatial frequency information is multiplied by a digital low-pass apodization filter which preferentially attenuates the higher spatial frequencies. The exact shape of the filter depends upon the imaging and illumination configuration of the exposure tool under simulation, and is adjustable in software. The technique is well-suited to both manual and high-speed automated photomask inspection and defect detection and classification using a single low-cost platform.
Proceedings of the Tenth International Workshop on Health Text Mining and Information Analysis (LOUHI 2019) (2019)

International audience
A Practical Synthesis ofm-Prostaglandin E Synthase-1 Inhibitor MK-7285 (2009)

A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proximity-induced anionic cyclization, followed by imidazole synthesis and late-stage cyanation.
Tandem Pd(II)‐Catalyzed Vinyl Ether Exchange—Claisen Rearrangement as a Facile Approach to γ,δ‐Unsaturated Aldehydes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Light-degradable hydrogels as dynamic triggers for gastrointestinal applications (2020)

Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe the development of a modular and tunable light-triggerable hydrogel system capable of interfacing with implantable devices. We apply these materials to two applications in the gastrointestinal (GI) tract: a bariatric balloon and an esophageal stent. We demonstrate biocompatibility and on-demand triggering of the material in vitro, ex vivo, and in vivo. Moreover, we characterize performance of the system in a porcine large animal model with an accompanying ingestible LED. Light-triggerable hydrogels have the potential to be applied broadly throughout the GI tract and other anatomic areas. By demonstrating the first use of light-degradable hydrogels in vivo, we provide biomedical engineers and clinicians with a previously unavailable, safe, dynamically deliverable, and precise tool to design dynamically actuated implantable devices.
Functionalization of Tactile Sensation for Robot Based on Haptograph and Modal Decomposition (2009)

In the real world, robots should be able to recognize the environment in order to be of help to humans. A video camera and a laser range finder are devices that can help robots recognize the environment. However, these devices cannot obtain tactile information from environments. Future human-assisting-robots should have the ability to recognize haptic signals, and a disturbance observer can possibly be used to provide the robot with this ability. In this study, a disturbance observer is employed in a mobile robot to functionalize the tactile sensation.This paper proposes a method that involves the use of haptograph and modal decomposition for the haptic recognition of road environments. The haptograph presents a graphic view of the tactile information. It is possible to classify road conditions intuitively. The robot controller is designed by considering the decoupled modal coordinate system, which consists of translational and rotational modes. Modal decomposition is performed by using a quarry matrix. Once the robot is provided with the ability to recognize tactile sensations, its usefulness to humans will increase.
Establishment of a New Human Pneumococcal Standard Reference Serum, 007sp (2011)

Lot 89SF has been the reference standard serum pool used in pneumococcal enzyme-linked immunosorbent assays (ELISAs) since 1990. In 2005, it was estimated that there remained between 2 and 5 years' supply of lot 89SF. Since lot 89SF was the reference standard used in the evaluation of the seven-valent pneumococcal conjugate vaccine Prevnar (PCV7), the link to clinical efficacy would be severed if stocks became completely depleted. Furthermore, demonstration of immune responses comparable to those elicited by PCV7 is a licensure approach used for new pneumococcal conjugate vaccines, so a replacement reference standard was required. A total of 278 volunteers were immunized with the 23-valent unconjugated polysaccharide vaccine Pneumovax II, and a unit of blood was obtained twice within 120 days following immunization. Plasma was prepared, pooled, and confirmed to be free from hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV. The pooled serum was poured at 6 ml per vial into 15,333 vials and lyophilized. Immunological bridging of 007sp to 89SF was used to establish equivalent reference values for 13 pneumococcal capsular serotypes (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) by five independent laboratories. Antibody concentrations in 007sp were established relative to the lot 89SF reference preparation using the WHO reference ELISA. Subsequently, 12 existing WHO calibration sera had concentrations reassigned for 13 pneumococcal serotypes using new serum 007sp as the reference, and these were compared to concentrations relative to the original reference serum. Agreement was excellent for the 12 WHO calibration sera. The 007sp preparation has replaced 89SF as the pneumococcal reference standard. Sufficient quantity of this new preparation is available such that, with judicious use, it should be available for at least 25 years.
Effect of Screw Type and Distribution on the Torsional Stability of 3.5 mm String of Pearls Locking Plate Constructs (2014)

A minimum of 1 bicortical screw/fragment should be used to increase torsional stability of 3.5 mm SOP constructs. Positioning this screw at the inner- or outermost positions relative to the fracture is preferred, with the innermost position providing the greatest improvement in stability. Should further torsional stability be desired, increasing the number of bicortical screws is recommended. Clinically, these results may assist with preoperative planning of various fracture patterns.
Clinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia (2015)

Thiazide diuretics are associated with an increased risk of hyponatremia. The aim of this study was to investigate possible predictors of thiazide-induced hyponatremia.A total of 48 patients admitted to the ward or to the emergency department due to severe thiazide-induced hyponatremia (Na < 125 mmol/L) were enrolled in our study as the case group. Another 211 hypertensive patients with normal sodium levels after treatment with thiazide diuretics were selected as the control group. Twelve tag single nucleotide polymorphism markers were selected from the Potassium Channel, Inwardly Rectifying Subfamily J, Member 1 (KCNJ1) gene: rs1231254, rs2238009, rs1148058, rs675482, rs673614, rs12795437, rs2855800, rs2509585, rs3016774, rs881333, rs4529890, and rs7116606. Clinical and genetic parameters between patients with thiazide-induced hyponatremia and the control group were compared. Logistic regression was used to analyze data.The patients with thiazide-induced hyponatremia were older (P < 0.001), predominantly female (P = 0.008), had a lower mean body mass index (BMI) (P < 0.001), and more commonly used angiotensin II receptor antagonist (P < 0.001) and spironolactone (P = 0.007) compared with the control groups. Analysis with multivariate logistic regression revealed that age (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.08-1.19, P < 0.001), female gender (OR, 4.49; 95% CI, 1.54-13.11, P = 0.006), BMI (OR, 0.80; 95% CI, 0.69-0.93, P = 0.003), and KCNJ1 rs2509585 C/T or T/T polymorphisms (OR, 5.75; 95% CI, 1.25-26.45, P = 0.03) were independent predictors for thiazide-induced hyponatremia.Older female patients with lower BMIs and KCNJ1 rs2509585 C/T or T/T polymorphisms were more likely to develop thiazide-induced hyponatremia.
Search for light long-lived neutral particles produced in pp collisions at $$\sqrt{s} = 13~\mathrm {TeV}$$ and decaying into collimated leptons or light hadrons with the ATLAS detector (2020)

Abstract Several models of physics beyond the Standard Model predict the existence of dark photons, light neutral particles decaying into collimated leptons or light hadrons. This paper presents a search for long-lived dark photons produced from the decay of a Higgs boson or a heavy scalar boson and decaying into displaced collimated Standard Model fermions. The search uses data corresponding to an integrated luminosity of 36.1 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/><mml:mrow><mml:mo>-</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:math> collected in proton–proton collisions at $$\sqrt{s} = 13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math> $$\text {Te}\text {V}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mtext>Te</mml:mtext><mml:mspace/></mml:mrow></mml:math> recorded in 2015–2016 with the ATLAS detector at the Large Hadron Collider. The observed number of events is consistent with the expected background, and limits on the production cross section times branching fraction as a function of the proper decay length of the dark photon are reported. A cross section times branching fraction above 4 pb is excluded for a Higgs boson decaying into two dark photons for dark-photon decay lengths between 1.5 mm and 307 mm.
Electro-Optic Responses of Antiferroelectric Liquid Crystals with Very Short Reverse Pulse Voltage (1993)

Electro-optic responses accompanied by field induced phase transitions from the ferroelectric state to the antiferroelectric state have been studied. The response time obtained with very short pulse of reverse polar voltage is seven hundred times as short as that without reverse pulse voltage. From the viewpoint of application, a two-field matrix-addressing waveform is also proposed.
Integrated Module Antenna for Automotive UWB Application (2022)

In this paper, an integrated module antenna for automotive UWB application is proposed. The target applications of the proposed antenna are for UWB localization and rear passenger detection. The purpose of this work is to design an antenna with a wide and narrow beamwidth that can be attached to the exterior/interior of a vehicle for simultaneous UWB localization and a rear passenger detection sensor with a single-module substrate in a limited space. For UWB localization, the wide beam coverage is required so the antenna receives the signal from any incident angle in horizontal plane. Meanwhile, the rear passenger detection sensor requires a relatively narrower beamwidth than the localization antenna for accurate detection within the vehicle. To integrate two different antennas into a single compact module substrate, modified ground stubs and parasitic radiators are applied. The size of the entire antenna structure is 35 mm × 65 mm × 1.156 mm. The proposed antenna designed on the multi-layered FR-4 substrate with a dielectric constant of 4.3. The bandwidth of the monopole is 6.14~8.24 GHz, and the patch array is 6.95~8.47 GHz. The isolation between the monopole and the patch array is less than −23 dBi in the target band. The performance of the proposed antenna is verified with simulation and measurement. In addition, a simulation of the proposed antenna with the real vehicle model is also conducted to verify the feasibility on actual vehicle. Based on this work, the proposed antenna can be applied to multi-function antenna for automotive application with low cost.
Generative Deep Learning Model for a Multi-level Nano-Optic Broadband Power Splitter (2020)

A novel Conditional Variational Autoencoder (CVAE) model with the adversarial censoring is presented to help to generate the 550nm broad bandwidth (1250nm to 1800nm) power splitter with arbitrary splitting ratio.
Extending the range of vision using diffractive intraocular lens technology (2015)

All authors are employees of Abbott Medical Optics, Inc.
Sensitized near-infrared emission from ytterbium(iii) via direct energy transfer from iridium(iii) in a heterometallic neutral complex (2008)

A tetrametallic iridium-ytterbium complex has been synthesised that shows sensitized near-infrared emission (lambda(max) = 976 nm) upon excitation of the iridium unit in the visible region (400 nm) due to efficient energy transfer from the iridium units to the Yb(III) ion. The iridium phosphorescence is quenched nearly quantitatively while the ytterbium ion emits brightly in the NIR.