gebhart/patrepeval huggingface dataset:
Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca2+ Overload in Retinal Pigment Epithelial Cells Independently of ROS (2021)

Retinal pigment epithelial (RPE) cells occupy the outer layer of the retina and perform various biological functions. Oxidative damage to RPE cells is a major risk factor for retinal degeneration that ultimately leads to vision loss. In this study, we investigated the role of spermidine in a hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced oxidative stress model using human RPE cells. Our findings showed that 300 μM H<sub>2</sub>O<sub>2</sub> increased cytotoxicity, apoptosis, and cell cycle arrest in the G2/M phase, whereas these effects were markedly suppressed by 10 μM spermidine. Furthermore, spermidine significantly reduced H<sub>2</sub>O<sub>2</sub>-induced mitochondrial dysfunction including mitochondrial membrane potential and mitochondrial activity. Although spermidine displays antioxidant properties, the generation of intracellular reactive oxygen species (ROS) upon H<sub>2</sub>O<sub>2</sub> insult was not regulated by spermidine. Spermidine did suppress the increase in cytosolic Ca<sup>2+</sup> levels resulting from endoplasmic reticulum stress in H<sub>2</sub>O<sub>2</sub>-stimulated human RPE cells. Treatment with a cytosolic Ca<sup>2+</sup> chelator markedly reversed H<sub>2</sub>O<sub>2</sub>-induced cellular dysfunction. Overall, spermidine protected against H<sub>2</sub>O<sub>2</sub>-induced cellular damage by blocking the increase of intracellular Ca<sup>2+</sup> independently of ROS. These results suggest that spermidine protects RPE cells from oxidative stress, which could be a useful treatment for retinal diseases.
A solvatochromic dye for probing significantly the dipolarity/polarizability of HBD (hydrogen bond donating) environments (2003)

The solvatochromism of the novel dye 4-tert-butyl-2-(dicyanomethylene)-5-[4-(diethylamino)benzylidene]-Δ3-thiazoline (1) has been investigated in 26 solvents of different polarity. 1 exhibits a positive solvatochromism, its solvent-induced bathochromic UV/Vis absorption band shift ranges from n-hexane (λmax = 566 nm) to dimethyl sulfoxide (λmax = 640 nm). The molar absorption energy of the solvatochromic band shift of 1 can be well correlated with Kamlet–Taft's and Catalàn's solvent polarity scales. 1 is mainly sensitive to the solvent's dipolarity/polarizability (π* of SPPN term) rather than of its HBD (hydrogen-bond donating) or HBA (hydrogen-bond accepting) property. It is emphasized that the UV/Vis absorption band maximum of 1 in the strong HBD solvents acetic acid, 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoropropan-2-ol fit well in the LSE (linear solvation energy) relationship with Kamlet and Taft's π* and Catalàn's SPPN scale, respectively, which makes this dye important as a dipolarity/polarizability indicator for various solid acids.
CLIPS++: Embedding CLIPS into C++ (1994)

This paper describes a set of C++ extensions to the CLIPS language and their embodiment in CLIPS++. These extensions and the implementation approach of CLIPS++ provide a new level of embeddability with C and C++. These extensions are a C++ include statement and a defcontainer construct; (include (c++-header-file.h)) and (defcontainer (c++-type)). The include construct allows C++ functions to be embedded in both the LHS and RHS of CLIPS rules. The header file in an include construct is the same header file the programmer uses for his/her own C++ code, independent of CLIPS. The defcontainer construct allows the inference engine to treat C++ class instances as CLIPS deftemplate facts. Consequently existing C++ class libraries may be transparently imported into CLIPS. These C++ types may use advanced features like inheritance, virtual functions, and templates. The implementation has been tested with several class libraries, including Rogue Wave Software's Tools.h++, GNU's libg++, and USL's C++ Standard Components. The execution speed of CLIPS++ has been determined to be 5 to 700 times the execution speed of CLIPS 6.0 (10 to 20X typical).
Abstract 3685: Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy (2023)

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. Patients have few therapeutic options, and disease progression is inevitable. Anti-PD-1/PD-L1 antibodies can induce potent anti-tumor immunity and have been approved as a first-line therapy for non-small cell lung cancer (NSCLC). However, only ~20% of all NSCLCs benefit from checkpoint blockade, underscoring the critical need for the development of new and innovative approaches to identify actionable therapeutic targets to treat NSCLC. We identified the Transmembrane Serine Protease TMPRSS11B as a novel gene that promotes the transformation of human bronchial epithelial cells in vitro and induces tumorigenesis in vivo (Updegraff et al., Cell Reports, 2018). Our data show that TMPRSS11B promotes solubilization of Basigin, an obligate chaperone of the lactate monocarboxylate transporters MCT1 and MCT4, and that TMPRSS11B interacts and co-localizes with Basigin and MCT4. Moreover, Basigin release mediated by TMPRSS11B enhances lactate export and glycolytic metabolism, thereby promoting tumorigenesis. This is of significant interest because TMPRSS11B is frequently overexpressed in human lung squamous cell cancers (LSCC) and high expression is associated with poor survival of NSCLC patients. Moreover, as a cell surface protein and enzyme, TMPRSS11B represents an exciting putative target for therapeutic intervention. Our new studies demonstrate that the catalytic activity of TMPRSS11B may be important for the interaction with Basigin and enhanced lactate export. We also evaluated the effect of Tmprss11b depletion in the KLN205 syngeneic LSCC mouse model. CRISPR/Cas9 knockout of Tmprss11b in KLN205 LSCC cells significantly reduced tumor burden in immunocompetent DBA/2 WT mice. Moreover, mass spectrometry analysis revealed TMPRSS11B-interacting proteins that may represent novel substrates of this enzyme. Current studies are focused on elucidating the molecular mechanisms through which TMPRSS11B promotes tumorigenesis and investigating the efficacy of TMPRSS11B inhibition in syngeneic and autochthonous mouse models of LSCC, where the effects on immune cell function will be assessed. Citation Format: Hari Shankar Sunil, Barrett Updegraff, Jingfei Zhu, Bret M. Evers, John D. Minna, Ralph J. Deberardinis, Trudy G. Oliver, Kathryn A. O'Donnell. Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3685.
Visually Fingerprinting Humans without Face Recognition (2015)

This paper develops techniques using which humans can be visually recognized. While face recognition would be one approach to this problem, we believe that it may not be always possible to see a person?s face. Our technique is complementary to face recognition, and exploits the intuition that human motion patterns and clothing colors can together encode several bits of information. Treating this information as a "temporary fingerprint", it may be feasible to recognize an individual with reasonable consistency, while allowing her to turn off the fingerprint at will.
Widely tunable compact terahertz gas lasers (2019)

The terahertz region of the electromagnetic spectrum has been the least utilized owing to inadequacies of available sources. We introduce a compact, widely frequency-tunable, extremely bright source of terahertz radiation: a gas-phase molecular laser based on rotational population inversions optically pumped by a quantum cascade laser. By identifying the essential parameters that determine the suitability of a molecule for a terahertz laser, almost any rotational transition of almost any molecular gas can be made to lase. Nitrous oxide is used to illustrate the broad tunability over 37 lines spanning 0.251 to 0.955 terahertz, each with kilohertz linewidths. Our analysis shows that laser lines spanning more than 1 terahertz with powers greater than 1 milliwatt are possible from many molecular gases pumped by quantum cascade lasers.
DNA Methylation in Lysogens of Pathogenic Burkholderia spp. Requires Prophage Induction and Is Restricted to Excised Phage DNA (2005)

Burkholderia mallei-specific phage PhiE125 encodes DNA methyltransferases in both the lysogenic and replication modules within its genome. Characterization of DNA methylation in recombinant systems, specifically in PhiE125 lysogenic strains of B. mallei and Burkholderia thailandensis, revealed that, upon induction, cytosine methylation was targeted specifically to the phage episome but not the phage provirus or the host chromosome.
Least in-sequence probability heuristic for mixed-volume production lines (1999)

http://deepblue.lib.umich.edu/bitstream/2027.42/35666/2/b2014294.0001.001.pdf
Diagnostic and Prognostic Significance of Tryptase in Clinical Hematology: A Single Center Experience from 1070 Patients. (2006)

Abstract Recent data suggest that tryptase is expressed in neoplastic cells in various myeloid neoplasms. In this study, serum tryptase levels were determined by a fluoroenzyme-immunoassay in 165 healthy subjects, in 925 patients (pts) with hematologic malignancies (myeloproliferative disorders, MPD, n=150; myelodysplastic syndromes, MDS, n=233; acute myeloid leukemia, AML, n=317; acute lymphatic leukemia, ALL, n=26, Non Hodgkin′s lymphomas, NHL, n=30; systemic mastocytosis, SM, n=89), and in a large cohort of control cases (pregnant women, n=11; hepathopathy, n=7; renal failure, n=18; helminth infections, n=29; reactive leukocytosis/thrombocytosis or idiopathic cytopenia, n=115). In healthy subjects, the 95%-percentile ranged between 2.4 and 9.5 ng/ml (median 5.7 ng/ml). Healthy controls aged ≤ 16 years had a slightly lower median serum tryptase level compared to older control subjects (p=0.03). Among pts with non hematologic disorders, slightly elevated serum tryptase levels (up to 24 ng/ml) were detectable in 6/18 pts with severe renal failure and in 3/29 pts with helminth infections. When analyzing hematologic malignancies, tryptase levels &gt;15 ng/ml could be detected in pts with myeloid neoplasms exclusively, whereas in most pts with lymphoproliferative disorders, tryptase levels were normal. Among myeloid neoplasms, elevated tryptase levels were recorded in 83% of the pts with SM, 36% of pts with AML, 34% of the pts with CML, and 29% of the pts with MDS. The highest tryptase levels, sometimes exceeding 1000 ng/ml, were found in pts with SM or AML-M4eo. In pts with CML, elevated tryptase levels were found to be associated with an unfavorable prognosis concerning survival (survival in CML pts with tryptase &lt;15 ng/ml: 100% vs 71% in those with &gt;15 ng/ml, after 60 months, p&lt;0.007). In most pts with AML, SM, or CML, the initially enhanced serum tryptase levels decreased in response to successful cytoreductive or targeted therapy. In pts with AML, a persistently elevated serum tryptase in complete hematologic remission (CR) was found to be associated with an increased risk of relapse compared to those with normal tryptase in CR. In summary, tryptase is a new and simple diagnostic marker of myeloid neoplasms. In SM, AML, and CML, tryptase is also a useful marker to monitor (minimal residual) disease during treatment with cytoreductive or targeted drugs. Moreover, in AML and CML, measurement of tryptase is of prognostic significance. All in all, tryptase is recommended as a new important serum-marker in clinical hematology.
ChemInform Abstract: POLAR EFFECTS IN FREE RADICAL REACTIONS. INDUCED DECOMPOSITIONS OF PEROXO COMPOUNDS IN THE SUBSTITUTION OF HETEROAROMATIC BASES BY NUCLEOPHILIC RADICALS (1985)

Abstract Die Zersetzung der Peroxide (II) bzw. (X) bzw. von K 2 S 2 O 8 in verschiedenen Lösungsmitteln führt zur selektiven Substitution in Stellung 2 von protoniertem Lepidin (I) durch die entsprechenden bei den Reaktionen erzeugten nucleophilen Radikale [‐ (VII), (IXa) + (lXb), (XI) bzw. (XV)] [Ausb.‐Angaben (Tabellen) in mmol].
Investigation of Bismuth Triiodide (BiI3) for Photovoltaic Applications (2015)

Guided by predictive discovery framework, we investigate bismuth triiodide (BiI3) as a candidate thin-film photovoltaic (PV) absorber. BiI3 was chosen for its optical properties and the potential for "defect-tolerant" charge transport properties, which we test experimentally by measuring optical absorption and recombination lifetimes. We synthesize phase-pure BiI3 thin films by physical vapor transport and solution processing and single-crystals by an electrodynamic gradient vertical Bridgman method. The bandgap of these materials is ∼1.8 eV, and they demonstrate room-temperature band-edge photoluminescence. We measure monoexponential recombination lifetimes in the range of 180-240 ps for thin films, and longer, multiexponential dynamics for single crystals, with time constants up to 1.3 to 1.5 ns. We discuss the outstanding challenges to developing BiI3 PVs, including mechanical and electrical properties, which can also inform future selection of candidate PV absorbers.
<title>Development Of A New Synchroscan Tube Incorporating A Microchannel Plate</title> (1983)

In the development of synchroscan tube operated over wide sweeping frequency, multi-pactor discharge which increases back ground noise of the tube, has been investigated in detail. It has been found that the problem of discharge can be solved mainly by suppressing the secondary electron emission from the electrodes in the deflecting section in the tube. On this result, a new synchroscan tube has been developed. This tube can be operated over wide sweeping frequency from 80MHz to 160MHz and the limiting time resolution of the tube itself of about 8ps has been obtained at 80MHz. Driving the tube in synchroscan mode is very easy because the tube has high deflection sensitivity, 50mm/kVp-p. Moreover, this tube incorporating a microchannel plate(MCP) is very high sensitive, by adding the effect of synchroscan mode.
G020034 Differential Pressure Distribution of a Butterfly Wing during Takeoff (2011)

This paper reports on direct measurement of differential pressure distribution on a butterfly wing during takeoff. Differential pressure was measured with a micro-fabricated sensor. A MEMS (Micro Electro Mechanical Systems) piezo-resistive cantilever was used as the differential pressure sensor. The sensor chip was 1.0 mm x 1.0 mm x 0.3 mm in size and 0.7 mg in weight. The sensor was attached to a butterfly (Papilio protenor) wing surface through a Cu/Polyimide substrate and Au wires. The total weight was 30 mg so that it did not interfere with flight condition. The distribution of five points to the spanwise direction at the forewing and one point at the center of the hindwing was measured during takeoff. As a result, it was clarified that the maximum differential pressure was 20 Pa on the forewing tip. Additionally, the maximum aerodynamic force generated on the wing was 3 times larger than the gravity acting on the body.
Optical activity of a chiral bicyclic orthoester (1993)

The circular dichroism (CD) spectra of two optically active bicyclic orthoesters have been measured in the vacuum UV (VUV) region; transitions to 3s, 3p and 3d Rydberg states are detected in the CD spectra; no indication for excitonic interaction between the three non-identical oxygen chromophores is observed.
Palladium/Chiral Amine Co‐catalyzed Enantioselective β‐Arylation of α,β‐Unsaturated Aldehydes (2012)

Palladium and a simple chiral amine are used as co-catalysts for the enantioselective conjugate addition of aryl boronic acids to α,β-unsaturated aldehydes (see scheme). The synthetic utility of this co-catalyzed reaction was demonstrated in the short total syntheses of (R)-(−)-curcumene and 4-aryl-2-ones. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Ionized physical vapor deposition of Cu using a mixture of rare gases (2001)

Ionized physical vapor deposition of Cu in a mixture of three rare gases (He–Ar–Xe) is explored in this article. Results indicate that total Cu flux to the wafer, ionization fraction of Cu at the wafer, and ratio of total effective ion flux to total Cu flux increase with increasing Xe concentration in the gas mixture. This is because of enhancement of electron density and Xe+ ions having a larger sputter yield on Cu than other ions. Increase in He concentration decreases the ionization fraction due to a lower electron density. However, Cu flux to the wafer increases because He is less effective in thermalizing the hot sputtered neutrals. One major consequence of these trends is that one can independently control total Cu flux to the wafer (corresponding to deposition rate) and ionization fraction (a major factor controlling the deposition profile) over a wide range by means of the buffer gas composition.
Diffraction Patterns of Si-based Polygonal Grating for 1-to-many Optical Interconnects (1996)

With the advent of higher clock speeds and distributed multiprocessor computer architectures, a great deal of interest has arisen in synchronously distributing a clock signal over all the processors in a computer with an acceptable clock skew [1]. Unfortunately, at clock speeds above 500 MHz, a synchronous global clock distribution system is very difficult to attain using electrical interconnects due to their inherent limitations. Because of the high bandwidth capability in optical signals, various guided wave optical clock distribution schemes have been investigated to alleviate such a problem. Photopolymer-based multiplexed volume holograms [2], surface relief gratings working at different diffraction orders [3] have been employed to achieve massive fanouts. However, due to the nature of non-multiplexibility, a surface relief grating is primarily employed as 1-to-l interconnect device with relatively low interconnectivity [4]. For 1-to-many fanout optical interconnects employing surface relief material with a single fanout node, a new device configuration is needed to solve this problem.
Tailoring the Permselectivity of Water Desalination Membranes via Nanoparticle Assembly (2014)

Thin film composite membranes can selectively separate mono- and divalent ions from water via solution-diffusion of each species through a dense but ultrathin, highly cross-linked polymer "skin" layer; water is transported across the membrane faster than associated salts. Changing the selectivity of the "skin" layer typically requires adjusting the monomer chemistries that make up the polymer "skin" layer, but doing so also impacts a host of other membrane properties. Here, we employ electrostatic layer-by-layer deposition of inorganic nanoparticles to enhance the permselectivity of an existing commercial nanofiltration membrane. We chose this approach because it is simple and robust and does not require any change to the underlying chemistry of the thin film composite (TFC) membrane. We found that a single layer of nanoparticles was sufficient to increase the permselectivity of the membrane by nearly 50%, compared to the virgin TFC membrane. In order to understand the mechanism for permselectivity enhancement, we developed a modified solution-diffusion model to account for the additional hydraulic resistance of the nanoparticle layer, which can faithfully capture the effect of nanoparticle layer thickness on the observed water and salt flux of the modified TFC membrane.
Development of a driftless Johnson noise thermometer for nuclear applications (2020)

Existing temperature sensors such as thermocouples and platinum resistance thermometers suffer from calibration drift, especially in harsh environments, due to mechanical and chemical changes (and transmutation in the case of nuclear applications). A solution to the drift problem is to use temperature sensors based on fundamental thermometry (primary thermometers) where the measured property is related to absolute temperature by a fundamental physical law. A Johnson noise thermometer is such a sensor and uses the measurement of the extremely small thermal voltage noise signals generated by any resistive element to determine temperature using the Johnson-Nyquist equation. A Johnson noise thermometer never needs calibration and is insensitive to the condition of the sensor material, which makes it ideally suited to long-term temperature measurement in harsh environments. These can include reactor coolant circuits, in-pile measurements, nuclear waste management and storage, and severe accident monitoring. There have been a number of previous attempts to develop a Johnson noise thermometer for the nuclear industry, but none have achieved commercialization because of technical difficulties. We describe the results of a collaboration between the National Physical Laboratory and Metrosol Limited, which has led to a new technique for measuring Johnson noise that overcomes the previous problems that have prevented commercialization. The results from a proof-of-principle prototype that demonstrates performance commensurate with the needs of nuclear applications is presented, together with details of progress towards the commercialization of the technology. The development partners have effected a step change in the application of primary thermometry to industrial applications and seek partners for field trials and further exploitation.
Vibrational analysis of 13-cis-retinal (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVibrational analysis of 13-cis-retinalBo Curry, Ilona Palings, Albert Broek, Johannes A. Pardoen, Patrick P. J. Mulder, Johan Lugtenburg, and Richard MathiesCite this: J. Phys. Chem. 1984, 88, 4, 688–702Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://doi.org/10.1021/j150648a015RIGHTS & PERMISSIONSArticle Views105Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Supporting Info (1)»Supporting Information Supporting Information Get e-Alerts