gebhart/patrepeval huggingface dataset:
Learning Non-Markovian Quantum Noise from Moiré-Enhanced Swap Spectroscopy with Deep Evolutionary Algorithm (2019)

Two-level-system (TLS) defects in amorphous dielectrics are a major source of noise and decoherence in solid-state qubits. Gate-dependent non-Markovian errors caused by TLS-qubit coupling are detrimental to fault-tolerant quantum computation and have not been rigorously treated in the existing literature. In this work, we derive the non-Markovian dynamics between TLS and qubits during a SWAP-like two-qubit gate and the associated average gate fidelity for frequency-tunable Transmon qubits. This gate dependent error model facilitates using qubits as sensors to simultaneously learn practical imperfections in both the qubit's environment and control waveforms. We combine the-state-of-art machine learning algorithm with Moiré-enhanced swap spectroscopy to achieve robust learning using noisy experimental data. Deep neural networks are used to represent the functional map from experimental data to TLS parameters and are trained through an evolutionary algorithm. Our method achieves the highest learning efficiency and robustness against experimental imperfections to-date, representing an important step towards in-situ quantum control optimization over environmental and control defects.
The ASM Journals Committee Values the Contributions of Black Microbiologists (2020)

Black lives matter. The ongoing problem of police brutality and the resulting deaths of George Floyd (1), Breonna Taylor (2), and many other Black people in the United States (3) has rightly shaken the country. Acts of racism should cause us to question the level to which we have personally participated in the systems of racial inequity that facilitate such acts. We all have an obligation to identify the ways that systemic racism functions in our society and in science. As scientists, we prefer to believe that we are driven by data and are immune to such detrimental behaviors. Yet, if we are honest, we know that this is not always true.
Stereoselective Synthesis of 2,6-Disubstituted 3-Piperidinols:  Application to the Expedient Synthesis of (+)-Julifloridine (2005)

[reaction: see text] The asymmetric synthesis of 2,6-disubstituted 3-piperidinols having a 2,3-cis and 2,6-trans relative stereochemistry was accomplished in three steps using the following sequence: stereocontrolled nucleophilic addition of an organomagnesium reagent to a chiral pyridinium salt; monohydrogenation of the resulting 2-substituted 1,2-dihydropyridine; and a one-pot, highly diastereoselective epoxidation-nucleophilic addition with a heteroatom nucleophile or an organometallic reagent. This methodology was applied to the expedient asymmetric synthesis of (+)-julifloridine in four steps.
ROCSAN trial (GINECO-EN203b/ENGOT-EN8): A multicentric randomized phase II/III evaluating dostarlimab in combination with niraparib versus niraparib alone compared to chemotherapy in the treatment of endometrial/ovarian carcinosarcoma after at least one line of platinum based chemotherapy. (2021)

TPS5604 Background: Gynecological carcinosarcomas (CS) are rare and highly aggressive tumors with a 5-year overall survival (OS) &lt; 10%. After initial treatment majority of patients (pts) relapse and receive diverse chemotherapies (CT) producing modest benefits. The median PFS in relapse after platinum based CT is less than 4 months and median OS less than 1 year. New innovative strategies are urgently needed. Since CS showed high DNA damage response activity and potentially a high tumor mutation load resulting in neo-antigens, a synergy between PARPi and anti-PD1 is expected. Methods: ROCSAN is a multicentric, randomized, open-label, integrated Phase II/III study. In the Phase II, 63 pts with recurrent or progressing endometrial or ovarian CS after at least a first line of platinum-based CT will be randomized (2:2:1) to receive either niraparib in monotherapy, niraparib in combination with dostarlimab or standard CT (paclitaxel, doxorubicine, gemcitabine, topotecan). Stratification factors include the number of previous CT lines (1 vs 2-3), FIGO stage at diagnosis (I-II vs III-IV), CS localisation (ovarian vs endometrial), and performance status (0-1 vs 2). The primary objective of the Phase II is to select the best experimental strategy between niraparib and dostarlimab/niraparib combination based on Response Rate at 4 months (RR-4M by RECIST1.1). A single stage design with a 10% unacceptable RR-4M and a 30% targeted RR-4M was used to determine Phase II sample size, assuming a 10% one sided alpha for each comparison and more than 90% power. A pick-the-winner selection design could be used in case of promising efficacy in each experimental arm. At the interim analysis, an Independent Data Monitoring Committee will make recommendation for the selection of the optimal experimental arm. The Steering committee could then support to continue enrolment for the international Phase III which is calibrated to detect an improvement in median OS from 7 months (Standard CT) to 11.7 months (best experimental arm). Assuming a 5% alpha level and 80% power, 133 additional pts could be randomized (2:1). Secondary endpoints include safety, PFS, PFS2, TTST, ORR, duration of response, patient report outcomes (assessed via EORTC QLQ-C30 OV28, HADS, PRO-CTCAE). A translational program supported by European Community is associated to the clinical study to identify predictive biomarkers of response/resistance to study treatments, to correlate with immune environment, a special focus on genetic instability and the EMT process will be included. Trial is currently recruiting only in France for the phase II part, the first pt was randomized in July 2020. Clinical trial information: NCT 03651206.
Kinetic Modeling of Hydrogen Production by Dehydrogenation of Polycyclic Naphthenes with Varying Degrees of Condensation (2022)

The kinetics of reactions of dehydrogenation of polycyclic naphthenes (cyclohexane, decalin, bicyclohexyl, <i>ortho</i>-, <i>meta</i>-, and <i>para</i>-isomers of perhydroterphenyl) is modeled on the basis of a formal comparison of kinetic equations of the 1st and 2nd orders based on real experimental data. It is shown that the reaction of the 1st order is predominating in the series of cyclohexane-bicyclohexyl-perhydroparatherphenyl. For all other substrates, the probability of describing the reaction in accordance with the equation of the 2nd order increases markedly, and for trans-decalin it becomes the predominant form of describing the kinetics of the reaction.
Structure and surface reactivity of transition-metal–oxo–organo clusters: contribution of liquid- and solid-state NMR to the characterization of the cluster Ti16O16(OEt)32 (2004)

Nano-building blocks, as metal–oxo–alkoxo clusters, defined as perfectly calibrated nanometric species, are good models for spectroscopic studies and good candidates for elaboration, by soft chemistry processes, of hybrid organic-inorganic materials. We focus our work on the cluster Ti 16 O 16 (OEt) 32 and its reactivity against propyl alcohol. A better understanding of the surface reactivity allows the elaboration optimisation of hybrid materials by a better control of the hybrid interface. The use of high-resolution liquid (COSY, HMQC) and solid-state (Cross Polarization, MAS) NMR spectroscopies will be described, in order to characterize properly the surface organic groups.
Beamforming Network Based on Novel Continuously Tunable Couplers (2022)

In this paper a new beamforming network for a given number of antenna elements is presented. The new architecture is capable of adaptively distributing an input RF signal among all individual antenna elements with an arbitrary selection of magnitudes and phases. The presented architecture is based on a novel coupler design, which is theoretically capable of an arbitrary division of power between its two output ports. The control of power division ratio is achieved by means of active elements capable of modulating its reactance, such as varactor diodes. As a demonstrator of the proposed beamforming concept, a feeder network for an array of 16 antenna elements is designed, simulated and fabricated to operate at a frequency of 2.5 GHz. The obtained results indicate an unprecedented level of reconfigurability, showing that the input signal can be divided among the antenna elements with arbitrary values of magnitudes and phases. The results are discussed.
615 X-Ray CT Observation of Macroscopic Casting Defects in ADC12 during Fatigue Process (2007)

Aim of this study is to unravel the effect of macroscopic casting defects on fatigue life of pressure die cast aluminium alloy. Macroscopic casting defects are highly dependent on the product shape or casting process. Therefore, a methodology of fatigue design is strongly demanded to take account of casting defects specific to the product. In this study, observation of casting defects by X-ray CT and tension-compression fatigue test are carried out. Three-dimensional image processing visualizes actual shape and configuration of casting defects, such as porosities, in the specimen before fatigue test. Visualization of porosities during fatigue test or after failure can also be used to investigate the fracture process. We found that crack initiation is almost restricted to from surface or near-surface defects, and shrinkage porosities can accelerate the crack propagation and reduce the failure life. Moreover, a plane defect, which was hardly observed by the X-ray CT, extremely decreased the fatigue life notwithstanding its location.
Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice (2018)

The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for developing idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a mucin thought to be restricted to conducting airways, is co-expressed with surfactant protein C (SFTPC) in type 2 alveolar epithelia and in epithelial cells lining honeycomb cysts, indicating that cell types involved in lung fibrosis in distal airspace express MUC5B. In mice, we demonstrate that Muc5b concentration in bronchoalveolar epithelia is related to impaired mucociliary clearance (MCC) and to the extent and persistence of bleomycin-induced lung fibrosis. We also establish the ability of the mucolytic agent P-2119 to restore MCC and to suppress bleomycin-induced lung fibrosis in the setting of Muc5b overexpression. Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.
Downloading SRA data using the SRA toolkit v1 (2016)

The Sequence Read Archive (SRA) is a database for biological sequence data and ismaintained by the National Center for Biotechnology Information (NCBI). Sequence files can be obtained by using the SRA Toolkit. This protocol provides the stepsnecessary to use the SRA toolkit to get sequence data in fastq format.
Interlaminar shear strength after high-temperature exposure of polyimide three-dimensional composites (2003)

For the realization of the next generation super sonic transports, the structure material requires high heat resistance property and lightweight. This research deals with the effect of high temperature exposure on inter-laminar shear strength of three-dimensional polyimide composite material which is one of the candidate materials for the structures of next generation super sonic transports. Polyimide composite material is exposured in the circumference with 180℃. After the exposure, the weight change is investigated and the inter-laminar shear strength test is carried out. The results are as follows; The weight of composite material slightly increases with the exposures. The inter-laminar shear strength of the composites decreases about 30% after 3000 hours exposure.
Endotoxin administration decreases plasma insulin-like growth factor (IGF)-I and IGF-binding protein-2 in Angus × Hereford steers independent of changes in nutritional intake (1995)

Endotoxemia and sepsis cause severe shifts in metabolism towards catabolic events. The objective of the research was to determine whether endotoxin administration changes plasma concentrations of IGF-I and IGF-binding protein-2 (IGFBP-2) in Angus x Hereford steers. In Experiment 1, mean feed intake in endotoxin-treated steers (n = 6) decreased 60% within the first 24 h after endotoxin and averaged, for the duration of the 96 h test period, an intake 35.5% lower than the mean ad libitum intake recorded prior to endotoxin. Plasma concentrations of IGF-I averaged 182 ng/ml in steers before endotoxin (E. coli, 055:B5, 0.2 micrograms/kg, i.v. bolus) and decreased an average of 24.2% at 24 to 96 h after endotoxin. In Experiment 2, a paired feeding strategy was used to determine whether the reduced feed intake was a significant factor in changing plasma concentrations of IGF-I and IGFBP-2 after endotoxin challenge. Steers were divided into endotoxin (0.2 micrograms/kg, i.v., n = 6) or control (saline, i.v., n = 3) treatments. Each of three endotoxin-treated steers was paired to a specific control. In this fashion, the adjusted feed intake of each endotoxin-treated steer was fed to it's paired control every 24 h through 96 h after endotoxin.(ABSTRACT TRUNCATED AT 250 WORDS)
Conclusions (2004)

Abstract This chapter synthesizes the findings of the case studies in this volume. These include the convergence of old local productive systems and weak national models towards models of networked firms, new high-tech activities, and the rise of small- and medium-sized enterprises (SMEs) despite new governance patterns in steel cities. Governance modes, local collective competition goods production, and policy implications are discussed.
Ease of use and comfort of a novel sensor insertion device for continuous glucose monitoring. (2015)

Background: In continuous glucose monitoring (CGM) the accurate positioning of the sensor in the subcutaneous tissue is a prerequisite for adequate sensor performance. In this study a novel insertion device was investigated with regard to success and reliability of sensor insertion, ease-of-use of the device and discomfort associated with the insertion procedure.

Methods: 50 people with diabetes inserted themselves two sensors, one at the abdomen and a second at the hip/buttock. To determine the insertion length, a sensor with a special scaling was used. The study was approved by the Institutional Review Board and subjects had signed written informed consent.

Results: The sensors were inserted successfully with an insertion length ≥8 mm leading to a success rate of sensor insertion of 100%. Pain upon sensor insertion was reported to be low (77.5%) or moderate (18.3%). In comparison to any of the compared measures in diabetes treatment, the discomfort associated with insertion was reported to be equal or less than finger pricking (79.6%), insulin injection (77.6%) and applying other CGM systems (83.3%). Regarding the handling of the insertion device, 80% of the subjects assessed it very easy to use, and 98% rated the operating steps easy to understand.

Conclusion: The novel CGM sensor insertion device can provide people with diabetes a reliable and easy to perform procedure for safe and successful sensor insertion with a minimum of discomfort, also when compared to other CGM devices and in comparison to other measures in diabetes treatment like insulin administration or finger pricking.
SAR Image Classification Using Few-Shot Cross-Domain Transfer Learning (2019)

Data-driven classification algorithms based on deep convolutional neural networks have reached human-level performance for many tasks within Electro-Optical (EO) computer vision. Despite being the prevailing visual sensory data, EO imaging is not effective in applications such as environmental monitoring at extended periods, where data collection at occluded weather is necessary. Synthetic Aperture Radar (SAR) is an effective imaging tool to circumvent these limitations and collect visual sensory information continually. However, replicating the success of deep learning on SAR domains is not straightforward. This is mainly because training deep networks requires huge labeled datasets and data labeling is a lot more challenging in SAR domains. We develop an algorithm to transfer knowledge from EO domains to SAR domains to eliminate the need for huge labeled data points in the SAR domains. Our idea is to learn a shared domain-invariant embedding for cross-domain knowledge transfer such that the embedding is discriminative for two related EO and SAR tasks, while the latent data distributions for both domains remain similar. As a result, a classifier learned using mostly EO data can generalize well on the related task for the SAR domain.
Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α1d Adrenergic Receptor (2004)

In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and synthesized. Structural variations of each part of the reference molecule have been introduced, obtaining highly selective ligands for the alpha(1d) adrenergic receptor. The molecular determinants for selectivity at this receptor are essentially held by the phenyl substituent in the phenylpiperazine moiety. The integration of an extensive SAR analysis with docking simulations using the rhodopsin-based models of the three alpha(1)-AR subtypes and of the 5-HT(1A) receptor provides significant insights into the characterization of the receptor binding sites as well as into the molecular determinants of ligand selectivity at the alpha(1d)-AR and the 5-HT(1A) receptors. The results of multiple copies simultaneous search (MCSS) on the substituted phenylpiperazines together with those of manual docking of compounds BMY 7378 and 69 into the putative binding sites of the alpha(1a)-AR, alpha(1b)-AR, alpha(1d)-AR, and the 5-HT(1A) receptors suggest that the phenylpiperazine moiety would dock into a site formed by amino acids in helices 3, 4, 5, 6 and extracellular loop 2 (E2), whereas the spirocyclic ring of the ligand docks into a site formed by amino acids of helices 1, 2, 3, and 7. This docking mode is consistent with the SAR data produced in this work. Furthermore, the binding site of the imide moiety does not allow for the simultaneous involvement of the two carbonyl oxygen atoms in H-bonding interactions, consistent with the SAR data, in particular with the results obtained with the lactam derivative 128. The results of docking simulations also suggest that the second and third extracellular loops may act as selectivity filters for the substituted phenylpiperazines. The most potent and selective compounds for alpha(1d) adrenergic receptor, i.e., 69 (Rec 26D/038) and 128 (Rec 26D/073), are characterized by the presence of the 2,5-dichlorophenylpiperazine moiety.
Forum (2006)

American Archivist, let me suggest that he read the article again, because he was apparently in a hurry the first time through or he is completely blinded by his own partisanship.The point of the address and the subsequent article was that the government classifies too much information contained in public records and keeps it classified for too long.As a result, many people do not take the system seriously, and genuinely important classified information is placed at risk.There is virtually universal agreement on this point.It is not, as Mr. Berry tries to portray the situation, Democrat versus Republican or liberal versus conservative.The article illustrates that overuse of classification is a longstanding concern that has pitted Congress against the executive branch of government.To convey the bipartisan nature of congressional concern, I used as examples quotes from such Republicans as Donald Rumsfeld and Trent Lott.Of the numerous examples cited, the
Speed of Efficacy and Delayed Toxicity Characteristics of Fast-Acting Fire Ant (Hymenoptera: Formicidae) Baits (2006)

Efficacy and speed of action of fire ant (Hymenoptera: Formicidae) baits that claim fast control of colonies were compared with a standard bait. More than 85% of red imported fire ant, Solenopsis invicta Buren, laboratory colonies provided bait containing the active ingredient indoxacarb died within 3 d, and all colonies were dead in 6 d. Standard bait containing hydramethylnon resulted in death of 60% of the colonies in 9 d. Bait containing spinosad did not cause colony death. Under field conditions, one-half of the areas treated with the indoxacarb bait did not have any active fire ant nests within 3 d, whereas 11 d was needed to reach the same level of control with the hydramethylnon bait. Spinosad had a maximum of 17% of the treated areas without nests after 3 d. The delay in death of S. invicta adults treated in the laboratory with the indoxacarb and spinosad baits was shorter than the standard hydramethylnon bait, which had mortality similar to the traditional delayed toxicity criterion of <15% mortality after 24 h and >89% mortality over the test period. Indoxacarb caused mortality of 57% at 24 h and 100% at 48 h; however, visual symptoms of toxicity were not readily observed for at least 8 h before the abrupt increase in death. Spinosad caused 96% mortality by 24 h, and initial mortality became apparent at 4 h. Time required for death of 15% of a treated population (LT15) of spinosad, indoxacarb, and hydramethylnon was 3, 9, and 16 h, respectively. Delayed toxicity characteristics of the fast-acting indoxacarb bait may be useful for the development of other fast-acting ant baits.
Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins (2023)

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.