gebhart/patrepeval huggingface dataset:
Supplementary Figure S3 from Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment (2023)

&lt;p&gt;Supplementary Figure S3 illustrates body weights for male and female monkeys after repeat dose administration of ARX788. ARX788 was administered by intravenous infusion to cynomolgus monkeys at 3.3 mg/kg/dose (n=6 females and 6 males), 10 mg/kg/dose (n=6 females and 6 males), or 15 mg/kg/dose (n=7 females and 7 males) once every 3 weeks, for 4 total doses. The control group (n=6 females and 6 males) was administered placebo once every 3 weeks, for 4 total doses. Animals treated with 15 mg/kg/dose ARX788 did not receive the third and fourth doses due to unexpected mortality and toxicity observed after the second dose. Body weights for male (A) and female (B) monkeys were monitored once weekly for the duration of the study.&lt;/p&gt;
Methane Emission Control (2016)

Natural gas is of increasing interest as an alternative fuel for vehicles and stationary engines that traditionally use gasoline and diesel fuels. Drivers for the adoption of natural gas include high abundance, lower price and reduced greenhouse gas emissions compared to other fossil fuels. Biogas is an option which could reduce such emissions further. The regulations which cap emissions from these engines currently include Euro VI and the US Environmental Protection Agency (EPA) greenhouse gas legislation. The regulated emissions limits for methane, nitrogen oxides (NOx) and particulate matter (PM) for both stoichiometric and lean burn compressed natural gas engines can be met by the application of either palladium-rhodium three-way catalyst (TWC) or platinum-palladium oxidation catalyst respectively. The drivers, policy and growth of this Pd based catalyst technology and its remaining challenges to be overcome in terms of cost and catalyst deactivation due to sulfur, water and thermal ageing are described in this short review.
Corrigendum: Insights into the Sesquiterpenoid Pathway by Metabolic Profiling and De novo Transcriptome Assembly of Stem-Chicory (Cichorium intybus Cultigroup “Catalogna”) (2017)

Stem-chicory of the 'Catalogna' group is a vegetable consumed for bitter-flavored stems. Type and levels of bitter sesquiterpene lactones (STLs) participate in conferring bitterness in vegetables. The content of lactucin- and lactucopocrin-like STLs was higher in 'Molfettese' than 'Galatina' landrace stalks, regardless of the cultivation sites, consistently with bitterness scores and gustative differences. The 'Galatina' transcriptome assembly resulted in 58,872 unigenes, 77% of which were annotated, paving the way to molecular investigation of the STL pathway. Comparative transcriptome analysis allowed the identification of 69,352 SNPs and of 1,640 differentially expressed genes that maintained the pattern independently of the site. Enrichment analyses revealed that 4 out of 29 unigenes were up-regulated in 'Molfettese' vs 'Galatina' within the sesquiterpenoid pathway. The expression of two germacrene A -synthase (GAS) and one -oxidase (GAO) genes of the costunolide branch correlated positively with the contents of lactucin-like molecules, supporting that STL biosynthesis regulation occurs at the transcriptional level. Finally, 46 genes encoding transcription factors (TFs) maintained a differential expression pattern between the two varieties regardless of the growth site; correlation analyses among TFs, GAS, GAO gene expressions and STLs contents suggest that one MYB and one bHLH may act in the pathway.
Novel Thermally Stable Polymer Materials for Second-Order Nonlinear Optics (1996)

A novel method of preparing thermally stable thin films with intrinsic second-order nonlinear optical activity is described. Design and synthesis yielded new ferroelectric bifunctional liquid crystalline acrylate monomer mixtures with a fast electro-optical response in the chiral smectic C (SmC*) phase. The ferroelectric liquid crystalline monomer mixtures were poled and subsequently cross-linked by in-situ photopolymerization in the surface-stabilized ferroelectric liquid crystal state. After cross-linking the polarization is no longer reversible, hence the material is pyroelectric and not ferroelectric. The cross-linked pyroelectric materials displayed a thermally stable nonlinear optical response.
Genetic and infectious regulators of baseline and acute immunity across ancestrally distinct human populations (2020)

Abstract Studies have identified genetic, viral, and immunological associations with the quality of anti-influenza immunity and/or influenza disease severity, however, there has not been an integrative analysis of these factors, both at baseline and during acute infection. Using samples from healthy or flu infected human cohorts across 5 countries, we found that herpesviruses (HVs) have unique and interactive effects on cytokine levels specific to anatomic location during flu infection. Similar cytokine associations were also observed in healthy controls. Additionally, HV infection is also associated with decreased flu severity and virus shedding, and increased antibody titers. Associations between cytokine levels and flu severity were consistent in cohorts of similar ancestral and environmental backgrounds, however unique correlates were observed in populations from distinct backgrounds. Further, we identified ~100 variants in immune related genes either enriched in or absent from a given ancestral population, a portion of which are eQTLs at baseline, supporting the potential of host genetics to impact immune variation. Ongoing work focuses on assessing which SNPs are eQTLs in response to bacterial and viral TLR agonists. Ancestry informative marker PCA values and eQTLs will be included in the statistical models to account for the collective effects of infectious, biological, and genetic factors. These results will provide insight into which factors predominantly affect a given immune measure and how this contributes to immune competence and variation across distinct populations. Understanding these interactions will have implications for other infectious diseases, autoimmunity, clinical study design, and immunotherapy.
A computational method for the analysis and prediction of protein:phosphopeptide‐binding sites (2004)

Phosphopeptide-binding domains, including the FHA, SH2, WW, WD40, MH2, and Polo-box domains, as well as the 14-3-3 proteins, exert control functions in important processes such as cell growth, division, differentiation, and apoptosis. Structures and mechanisms of phosphopeptide binding are generally diverse, revealing few general principles. A computational method for analysis of phosphopeptide-binding domains was therefore developed to elucidate the physical and chemical nature of phosphopeptide binding, given this lack of structural similarity. The surfaces of nine phosphopeptide-binding proteins, representing seven distinct classes of phosphopeptide-binding modules, were discretized, and encoded with information about amino acid identity, surface curvature, and electrostatic potential at every point on the surface in order to identify local surface properties enriched in phosphoresidue contact sites. Cross-validation indicated that propensities corresponding to this enrichment calculated from a subset of the training data could be used to predict the phosphoresidue contact site on proteins not used in training with no false negative results, and with few unconfirmed positive predictions. The locations of phosphoresidue contact sites were then predicted on the surfaces of the checkpoint kinase Chk1 and the BRCA1 BRCT repeat domain, and these predictions are consistent with recent experimental evidence.
Karola Fings, Sinti e rom. Storia di una minoranza, Bologna, il Mulino, 128 pp., € 12,00 (ed. or. München, Beck C.H., 2016, traduzione di Alessandro Dal Lago) (2019)

recensione del volume più recente su storia delle minoranze rom e Sinti dal punto di vista storico-educativo in contesto europeo. L'autrice è riferimento a livello internazionale sulle tematiche affrontate
Activating C-H Bonds Over C-Br Bonds to Make Oligothiophenes (2006)

Expanding on previous work, Mori and co-workers have developed an efficient method to preferentially activate the C-H bond located alpha to the sulfur in thiophene, even in brominated thiophenes. While their previous work utilized AgF, the less expensive and more robust combination of AgNO3 and KF is preferred here, though in both cases a superstoichiometric amount is required. Precaution should be taken when working up the reaction because hydrofluoric acid is a byproduct, along with metallic silver. The use of the resulting brominated oligothiophenes in the Stille and Sonogashira reaction is demonstrated.
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications. (1990)

Cathepsin D is a ubiquitously expressed lysosomal protease. Initially synthesized as an inactive precursor of 52 kD (pro-cathepsin D), the enzyme is subsequently converted to its active forms by proteolytic processing. Breast cancer cells, unlike normal cells, secrete high levels of pro-cathepsin D; this abnormal secretion is due to both overexpression of the gene and altered processing of the protein. Recent transfection experiments indicate that overexpression of cathepsin D can increase the metastatic potential of tumor cells in nude mice. This study complements clinical studies, which have shown than high cathepsin D concentrations in the cytosol of primary breast cancers may be predictive of subsequent metastasis, particularly for patients with axillary node-negative tumors. These results, and the potential mechanisms by which cathepsin D may promote metastasis, are considered here.
Vegf or EphA2 Antisense Polyamide-nucleic acids; Vascular Localization and Suppression of Retinal Neovascularization (2007)

Localized gene knockdown is a valuable tool for investigating the function of gene products in tissues. It may also be a good therapeutic strategy for selective targeting of a gene product implicated in disease pathogenesis. While small interfering RNAs (siRNAs) are useful for localized gene knockdown and have achieved well-deserved attention, other strategies may also have applications. Polyamide nucleic acids (PNAs) are DNA-protein chimeric molecules that can be designed with modifications so as to allow good cell entry and high affinity binding to complementary RNA. After intraocular injection of fluorescein isothiocyanate (FITC)-labeled antisense PNAs directed against Vegf or EphA2 (genes that are highly expressed in retinal vessels), labeling was observed to persist in retinal blood vessels even after staining elsewhere in the retina had faded. This did not occur after injection of FITC-labeled antisense human cAMP responsive element binding protein 1 (hCreb) PNA. Subretinal injection of antisense EphA2 PNA was seen to label choroidal blood vessels. Intraocular injection of antisense Vegf PNA or antisense EphA2 PNA significantly reduced their respective target messenger RNAs (mRNAs) in ischemic retinas and suppressed retinal neovascularization (NV). These data suggest that signaling through EphA2 contributes to retinal NV, and that antisense PNAs may be an advantageous way to target EphA2 and other endothelial cell receptors that contribute to ocular NV.
Nucleotide sequence of tDNA(Cys)GCA and its flanking regions fromZea mayschloroplasts (1988)

An isolated tRNA(Cys) gene upstream and on the opposite strand to the rpoB gene in maize chloroplasts is localized analogously to the gene in tobacco (1) and liverwort (2). A "-35"-type promoter sequence (3) in maize is underlined.
Ivy Bridge Server: A Converged Design (2015)

The Intel microarchitecture code named Ivy Bridge (IVB) represents Intel's first processor (CPU) design that services product markets from high-end desktops to mission-critical computing. With one converged design, IVB enables a rich portfolio of products and meets power, performance, and cost targets through multiple die options and configurations. IVB is the first server CPU using Intel's 22-nm process technology. It achieves scalability in die size, core count, cache size, socket count, and memory size while improving power efficiency and decreasing idle power.
Role of PSMA PET-guided metastases-directed therapy in oligometastatic recurrent prostate cancer (2022)

Oligometastatic prostate cancer (OMPC) has been proposed as an intermediary state between localised disease and widespread metastases, with varying definitions including 1, 3, or ≤5 visceral or bone metastasis. Traditional definitions of OMPC are based on staging with conventional imaging, such as computerised tomography (CT) and whole-body bone scan (WBBS). Novel imaging modalities such as prostate-specific membrane antigen positron emission tomography (PSMA PET) have improved diagnostic utility in detecting early metastatic prostate cancer (PC) metastases compared with conventional imaging. Specifically, meta-analytical data suggest that PSMA PET is sensitive in detecting oligometastatic disease in patients with biochemical recurrence (BCR) post-radical treatment of PC. Recent trials have evaluated PSMA PET-guided metastases-directed therapy (MDT) in oligometastatic recurrent disease, typically with salvage surgery or radiotherapy (RT). To date, these preliminary studies demonstrate promising results, potentially delaying the need for systemic therapy. We aim to report a comprehensive, multidisciplinary review of PSMA-guided MDT in OMPC. In this review, we highlight the utility of PMSA PET in biochemically recurrent disease and impact of PSMA PET on the definition of oligometastatic disease and outline data pertaining to PSMA-guided MDT.
Suppl Figure S11 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma (2023)

&lt;p&gt;S11: Immunohistological analysis of orthologic slice cultures.&lt;/p&gt;
Evaluation of five different renal recovery definitions for estimation of long-term outcomes of cardiac surgery associated acute kidney injury (2019)

ADQI or ATN-equivalent criteria may overestimate the extent of renal recovery, while KDIGO, Pannu and Bucaloiu equivalent criteria may be more appropriate for clinical use. Our analyses revealed that SCr at discharge > 30% or > 0.4 mg/dL of baseline, or eGFR < 70% of baseline led to significant 3-year MAE incidence differences, which may serve as hints for new definitions of renal recovery.
Assessing the capability of conventional in-cylinder insulation materials in achieving temperature swing engine performance benefits (2017)

Materials that enable wall temperature swing to follow the gas temperature throughout a reciprocating internal combustion engine cycle promise the greatest benefits from in-cylinder insulation without detriments to volumetric efficiency or fuel autoignition behavior. An anisotropic barium–neodymium–titanate insulation was selected as a promising off-the-shelf material to begin investigating temperature swing characteristics while maintaining adequate strength and adherence to the aluminum components it was applied to. Experimental analysis showed that permeable porosity within the barium–neodymium–titanate coating resulted in increased heat losses despite thermal insulation, fuel absorption losses, and a reduction in compression ratio. Additionally, the thickest coating suffered severe degradation throughout testing. Any potential benefits of temperature swing insulation were dominated by these losses, emphasizing the need to maintain a sealed coating surface.
A Method Using Laser Doppler Flowmetry to Study Intestinal and Pancreatic Perfusion during an Acute Intestinal Ischaemic Injury in Rats with Pancreatitis (2001)

Intestinal ischaemia is implicated in the pathogenesis of severe acute pancreatitis, a disorder characterized by acinar necrosis. To study the relationship between pancreatic and intestinal microvascular perfusion during 40 min of intestinal ischaemia and 30 min of reperfusion in rodents with acute pancreatitis, a model utilizing laser Doppler flowmetry was developed. It is reported here together with practical solutions for (1) a modified method of vessel cannulation; (2) a novel method for the temperature-controlled optical coupling between laser Doppler probes and rodent tissues, and (3) a simple technique of inducing intestinal ischaemia-reperfusion while continuously monitoring the microvascular perfusion in both pancreas and intestine. The utility of the model is demonstrated in a pilot study that showed that the pancreatic perfusion fell acutely to 58% (p = 0.029) of baseline during the intestinal reperfusion phase. This reduced perfusion continued for 30 min despite recovery of both the intestinal perfusion and the mean arterial blood pressure to baseline levels.
Biaxial deformation of collagen and elastin fibers in coronary adventitia (2013)

The microstructural deformation-mechanical loading relation of the blood vessel wall is essential for understanding the overall mechanical behavior of vascular tissue in health and disease. We employed simultaneous mechanical loading-imaging to quantify in situ deformation of individual collagen and elastin fibers on unstained fresh porcine coronary adventitia under a combination of vessel inflation and axial extension loading. Specifically, the specimens were imaged under biaxial loads to study microscopic deformation-loading behavior of fibers in conjunction with morphometric measurements at the zero-stress state. Collagen fibers largely orientate in the longitudinal direction, while elastin fibers have major orientation parallel to collagen, but with additional orientation angles in each sublayer of the adventitia. With an increase of biaxial load, collagen fibers were uniformly stretched to the loading direction, while elastin fibers gradually formed a network in sublayers, which strongly depended on the initial arrangement. The waviness of collagen decreased more rapidly at a circumferential stretch ratio of λθ = 1.0 than at λθ = 1.5, while most collagen became straightened at λθ = 1.8. These microscopic deformations imply that the longitudinally stiffer adventitia is a direct result of initial fiber alignment, and the overall mechanical behavior of the tissue is highly dependent on the corresponding microscopic deformation of fibers. The microstructural deformation-loading relation will serve as a foundation for micromechanical models of the vessel wall.
Multilocus Analysis of Hypertension: A Hierarchical Approach (2004)

While hypertension is a complex disease with a well-documented genetic component, genetic studies often fail to replicate findings. One possibility for such inconsistency is that the underlying genetics of hypertension is not based on single genes of major effect, but on interactions among genes. To test this hypothesis, we studied both single locus and multilocus effects, using a case-control design of subjects from Ghana. Thirteen polymorphisms in eight candidate genes were studied. Each candidate gene has been shown to play a physiological role in blood pressure regulation and affects one of four pathways that modulate blood pressure: vasoconstriction (angiotensinogen, angiotensin converting enzyme – ACE, angiotensin II receptor), nitric oxide (NO) dependent and NO independent vasodilation pathways and sodium balance (G protein-coupled receptor kinase, GRK4). We evaluated single site allelic and genotypic associations, multilocus genotype equilibrium and multilocus genotype associations, using multifactor dimensionality reduction (MDR). For MDR, we performed systematic reanalysis of the data to address the role of various physiological pathways. We found no significant single site associations, but the hypertensive class deviated significantly from genotype equilibrium in more than 25% of all multilocus comparisons (2,162 of 8,178), whereas the normotensive class rarely did (11 of 8,178). The MDR analysis identified a two-locus model including ACE and GRK4 that successfully predicted blood pressure phenotype 70.5% of the time. Thus, our data indicate epistatic interactions play a major role in hypertension susceptibility. Our data also support a model where multiple pathways need to be affected in order to predispose to hypertension.
Photoaffinity inactivation of the gastric (H+ + K+)-ATPase at a site involved in ion translocation (1988)

Conference Article| October 01 1988 Photoaffinity inactivation of the gastric (H+ + K+)-ATPase at a site involved in ion translocation COLIN FALLOWFIELD; COLIN FALLOWFIELD 1Smith Kline & French (Research) Ltd, The Frythe, Welwyn, Herts AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar KENNETH W. M. LAWRIE; KENNETH W. M. LAWRIE 1Smith Kline & French (Research) Ltd, The Frythe, Welwyn, Herts AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID SAUNDERS; DAVID SAUNDERS 1Smith Kline & French (Research) Ltd, The Frythe, Welwyn, Herts AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROBERT J. IFE; ROBERT J. IFE 1Smith Kline & French (Research) Ltd, The Frythe, Welwyn, Herts AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID J. KEELING DAVID J. KEELING 1Smith Kline & French (Research) Ltd, The Frythe, Welwyn, Herts AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1988) 16 (5): 823. https://doi.org/10.1042/bst0160823 Article history Received: April 04 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation COLIN FALLOWFIELD, KENNETH W. M. LAWRIE, DAVID SAUNDERS, ROBERT J. IFE, DAVID J. KEELING; Photoaffinity inactivation of the gastric (H+ + K+)-ATPase at a site involved in ion translocation. Biochem Soc Trans 1 October 1988; 16 (5): 823. doi: https://doi.org/10.1042/bst0160823 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: SCH 28080, 2-methyl-8-(phenylmethoxy)-imidazo[1,2-α]pyridine-3-acetonitrile, AT1P1, 8-(3-azidobenzyloxy)-1,2,3-trimethylimidazo[1,2-α]pyridinium iodide This content is only available as a PDF. © 1988 Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Filterless Ultraviolet Detector Based on Cerium Fluoride Thin Film Grown by Pulsed Laser Deposition (2012)

We report on an ultraviolet photoconductive detector based on cerium fluoride (CeF 3 ) thin films. CeF 3 thin films were grown on quartz glass substrates by the pulsed laser deposition (PLD) method. Optimization of the substrate temperature using the PLD method successfully increased the photocurrent of the CeF 3 detector. The photocurrent increases linearly up to at least 600 V. The sample grown at 670 K shows the highest crystallinity and orientation. This sample shows a response in the wavelength range below 310 nm without any filters. Additionally, the measured dielectric-breakdown field of this detector exceeded 15 kV/cm.