gebhart/patrepeval huggingface dataset:
Qualification of Dynamic Pressure Distribution on Wafer by Pressure Sensing Sheet during Polishing (2009)

A dynamic pressure distribution on wafer in real time measured by a pressure sensing sheet during polishing was studied. A correlation between non-uniformity of pressures on wafer during polishing and that of removal rate was observed, when the applied down pressure or flatness of wafer suceptor was changed. When the platen rotation rate increased, significant leading edge phenomenon observed by a dynamic pressure measurement resulted in degradation of the non-uniformity of removal rate. The dynamic pressure distribution measurement by the pressure sensing sheet was proposed to be a feasible method to improve quality of polishing process, such as non- uniformity of removal rate as well as to study polishing mechanism.
NeuroChat with Professor Clinton E. Canal (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNeuroChat with Professor Clinton E. CanalCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttp://orcid.org/0000-0003-0168-1445 and Clinton E. CanalClinton E. CanalMore by Clinton E. Canalhttp://orcid.org/0000-0002-7940-933XCite this: ACS Chem. Neurosci. 2020, 11, 21, 3485–3487Publication Date (Web):November 4, 2020Publication History Published online4 November 2020Published inissue 4 November 2020https://pubs.acs.org/doi/10.1021/acschemneuro.0c00565https://doi.org/10.1021/acschemneuro.0c00565editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1116Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1006 KB) Get e-AlertscloseSUBJECTS:Neurophysiology,Pharmaceuticals,Pharmacology,Receptors Get e-Alerts
Maintenance of gearbox bearings in a wind turbine: single versus group replacements (2015)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Tailoring Micrometer-Long High-Integrity 1D Array of Superparamagnetic Nanoparticles in a Nanotubular Protein Jacket and Its Lateral Magnetic Assembling Behavior (2015)

Tailoring of a micrometer-long one-dimensional (1D) array of superparamagnetic iron oxide nanoparticles (SNPs) was achieved by Mg(2+)-mediated supramolecular polymerization of a SNP-containing chaperonin protein (GroELMC⊃SNP). The inclusion complex GroELMC⊃SNP formed when ligand-modified SNPs were mixed with GroELMC, a GroEL mutant having multiple merocyanine (MC) units at its apical domains. Upon mixing with MgCl2 in phosphate buffer, GroELMC⊃SNP polymerized via the formation of multiple MC-Mg(2+)-MC coordination bonds, yielding thermodynamically stable micrometer-long nanotubes encapsulating 1D-arrayed SNPs (NTGroEL⊃SNP). When the NTGroEL⊃SNP nanotubes in phosphate buffer were incubated in a 0.5 T magnetic field, they began to assemble laterally and then organized into thick 1D bundles, where longer nanotubes were more preferentially incorporated. When the applied magnetic field was turned off, such bundles disassembled back to the individual 1D nanotubes. Lateral assembly of 1D SNP arrays in a magnetic field has been theoretically predicted but never been proven experimentally.
A simplified approach to a nonlinear loudspeaker modeling (1997)

Exact solutions of the nonlinear equations for a loudspeaker are extremely difficult to solve as they involve Volterra series expansions and higher-order system functions and impulse responses [A. R. Kaiser et al., J. Audio Eng. Soc. 35, 421–433]. Indeed, these complex methods are required for exact system simulations, however, they can be greatly simplified with a reasonable assumption about the system. By assuming that the distortion (or nonlinearity) is not so large that it causes an excessive amount of distortion, say about 20% THD, a vastly simplified approach can be developed. It is not always the case that this near-linear assumption can be made, but clearly, it should be accurate for higher performance units. This presentation will show how to use an algebra processor (Maple) to develop these simplified predictions given the nonlinearities of the parameters. These equations will then be used to show the effect that various loudspeaker enclosure designs have on the distortion of a given (typical) loudspeaker using a commercially available software package written by the author.
Overview for the Second Shared Task on Language Identification in\n Code-Switched Data (2019)

We present an overview of the second shared task on language identification\nin code-switched data. For the shared task, we had code-switched data from two\ndifferent language pairs: Modern Standard Arabic-Dialectal Arabic (MSA-DA) and\nSpanish-English (SPA-ENG). We had a total of nine participating teams, with all\nteams submitting a system for SPA-ENG and four submitting for MSA-DA. Through\nevaluation, we found that once again language identification is more difficult\nfor the language pair that is more closely related. We also found that this\nyear's systems performed better overall than the systems from the previous\nshared task indicating overall progress in the state of the art for this task.\n
Performance boost of crystalline in-Ga-Zn-O material and transistor with extremely low leakage for IoT normally-off CPU application (2017)

The worldwide first 100MHz dynamic oxide semiconductor RAM (DOSRAM) is successfully demonstrated using a new high-mobility crystalline In-Ga-Zn-O (IGZO) material. The new IGZO exhibits around two times carrier mobility of conventional IGZO, while still achieving an extremely low off-state leakage (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ) at ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-21</sup> A (zA) level. Attributed to DOSRAM performance improvement, 100MHz normally-off (Noff) CPU is successfully demonstrated with drastically reduced power consumption (~94% power reduction for ARM Cortex-M0 and ~70% power reduction for memory), making it a promising candidate for IoT application. In addition, an OS-FPGA is successfully fabricated by integration of 65nm SiFET and 60nm oxide semiconductor FET (OSFET) with an operation frequency of 360MHz. The application of the OSFET in analog circuits will also be discussed in this paper.
Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin (2013)

Putative cancer stem cells are a subpopulation of cancer cells that give rise to chemotherapy resistance and are therefore of prognostic and therapeutic interest, though their identification remains elusive in colon cancer due to lack of reliable and accurate markers. We previously identified a p53-dependent putative cancer stem cell population, the calcein low population (C(lo)P), based on their exclusive efflux of the fluorescent dye Calcein. This functional identification method enables comparative live cell studies of subpopulations without differential toxicity that occurs with traditional Hoechst methods, which has confounded conclusions and limited the utility of this cancer stem cell marker. In this study, we examined the cancer stem cell-like properties of the C(lo)P population in vivo in comparison with the parental and calcein-high population (C(hi)P) in human colon cancer xenografts. Serial dilution xenograft experiments in NOD/SCID mice revealed that the C(lo)P is only marginally more tumorigenic compared to the C(hi)P or parental cells. However, serial passage of these tumors revealed that the C(lo)P is uniquely enriched for self-renewal capacity in vivo compared to the other populations. Immunohistochemical analysis of these tumors revealed that the C(lo)P possesses increased levels of nuclear β-catenin and furthermore, siRNA-mediated knockdown of β-catenin significantly reduced the C(lo)P population. These findings highlight the C(lo)P as an important subpopulation of tumor cells that are exclusively endowed with the ability to self-renew and propagate tumors. The dependency of the C(lo)P on β-catenin provides a molecular explanation for this ability and suggests that this population can and should be therapeutically targeted by inhibition of Wnt signaling.
Evidence for the co‐storage and co‐release of neuropeptide y and noradrenaline from large dense cored vesicles in sympathetic nerves of the bovine vas deferens (1988)

The subcellular localization and the secretion of neuropeptide Y were studied in sympathetic nerve endings of bovine vas deferens. Immunostaining revealed a parallel distribution for neuropeptide Y and dopamine-beta-hydroxylase immunoreactivity in the network of varicose nerve fibers in the smooth muscle layers of the vas deferens. Following differential centrifugation and sucrose density gradient centrifugation, neuropeptide Y was found to coincide with noradrenaline in the more dense region of the gradient, where the large dense cored vesicles are found. Superfusion experiments demonstrated the release of neuropeptide Y and noradrenaline upon electrical stimulation. Furthermore, the neuropeptide Y secretion was shown to be Ca2+-dependent. We conclude that in the bovine vas deferens neuropeptide Y is only present in large dense cored vesicles of adrenergic neurons and that the peptide and noradrenaline are co-released from these vesicles in a calcium dependent manner.
Semiconductor ZnO Nano-Rods Thin Film Grown on Silver Wire for Hemoglobin Biosensor Fabrication (2015)

Wurtzite hexagonal ZnO semiconductor nano-rods (NRs) thin films were grown on silicon substrates and silver wire with diameter equal 68 nm. Sol gel (SG) and aqueous chemical growth (ACG) methods by two steps of preparation (seed layers and nano-rod growth) are used for samples preparation. The structural and morphological properties are evaluated using X-ray diffraction (XRD) and scanning electron microscope (SEM). The proposed iron ion sensor has shown good linearity for a wide concentration range from 0.078 M/L to 0.26 M/L of iron ions. The results show that the electrode is highly sensitive to iron ions with a slope around 47.8 mV/decade with a regression coefficient R2 = 0.96.
Effect of Acidity on the Deintercalation of Organically Modified Layered Silicates (2002)

We are very grateful to the financial support from the Korean Ministry of Education through the Brain Korea 21 Program, the National&#13;\nResearch Laboratory Fund from the Ministry of Science and Techlogy (MOST), and the Seoul National University Nanoelectronics Institute.
Injection Cryolipolysis: First-in-human Study (2021)

Ice slurry injections are feasible, with an observed safety and tolerability profile comparable to topical cryolipolysis. The ice slurry can cool tissue to induce cryolipolysis, as observed by thermal imaging, ultrasound, and tissue histology, and is selective for ice-injected sites. No significant changes were observed in control sites. The ice slurry may be a promising candidate to enable more precise, effective, and customizable aesthetic fat reduction that warrants further investigation.
Surface Modification Using Spiropyran-Derivative and Its Analysis of Surface Potential Induced by UV (2011)

스파이로파이란이 함유된 물질은 자외선의 조사(irradiation)에 의해 메로시아닌 파생물로 변화되는데 이 물질은 페놀레이트 음이온과 아민 양이온으로 구성된 쌍극성(zwitterion) 이온을 가지고 있다. 이와 같은 메로시아닌 표면위에서 페놀레이트 음이온과 니켈 금속 양이온의 복합화는 표면 전하의 변화를 일으키며, 이를 Kelvin prove force microscopy (KFM)를 이용하여 측정하였다. 자외선 노출 시간에 따라 쌍극성 이온의 발생량의 정도가 달라지고, 이것을 표면 전위를 통해서 금속 이온을 매개로 간접적으로 측정할 수 있었으며 표면 전위는 자외선 노출시간이 증가함에 따라 선형적으로 감소하다가 결국 포화상태가 됨을 관측하였다. 또한 자외선 노출 시간이 증가함에 따라 니켈 이온의 부착된 양이 증가되는 결과를 XPS 방법을 사용하여 분석할 수 있었다. 이러한 성질은 다른 금속 이온의 검출 및 양적 분석을 위해 이용될 수 있을 것으로 생각되며, 금속이온과 결합 가능한 단백질이나 세포와 같은 생체물질을 양적 변화를 표면 전하량에 따라 제어할 수 있는 가능성을 제시하였다. 지금까지의 결과를 바탕으로 고선택성, 고감도를 가지고, 생체 물질의 정량적인 제어가 가능한 지지체 혹은 바이오칩을 만들 수 있을 것으로 예상한다. Merocyanine derivatives transformed from spiropyran-containing compounds by irradiating the light of ultraviolet (UV) include zwitterion of phenolate anion and amine cation. Complexation of this phenolate anion on merocyaninemodified surface and Ni ion among metal ions led to a change of surface charge and it was measured with kelvin prove force microscopy (KFM). We found that the resultant surface potential decreased linearly as UV-exposed time increased, and finally were saturated. Also it was analyzed through XPS the immobilized amount of Ni ions was increased according to increase of UV-exposed time. It is considered that these properties could be applied for detection and a quantitative control of different metal ions. Further research is to aim construct specific scaffold/matrix which enable high selective, high sensitive and, especially, a quantitative immobilization of metal ions-binding biomaterials such as proteins and cells.
A Longitudinal Molecular Surveillance Study of Human Polyomavirus Viremia in Heart, Kidney, Liver, and Pancreas Transplant Patients (2005)

In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.
Motion Blur Compensation Of CCD Endoscope Images By Color Deviation Method (1987)

Recently, medical endoscopes with CCD camera devices have been developed and aroused great interest because of a larger number of picture elements than conventional endoscopes with optical fiber bundles. One type of image acquisition system is such that color images are sequentially taken with red (R), green (G) and blue (B) illuminations. This type has the merit of a good spatial resolution but constructed images are sometimes blurred or color shifted because of a rapid object motion while recording three primary color images. Since three primary color images have strong correlation, this problem can be solved by a compensation method using phase correlation l). This paper shows an advanced technique named the color deviation method which is much simpler than the previous method.
Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways (2017)

The aggregation into amyloid fibrils of amyloid-β (Aβ) peptides is a hallmark of Alzheimer's disease. A variety of Aβ peptides have been discovered <i>in vivo</i>, with pyroglutamate-modified Aβ (pEAβ) forming a significant proportion. pEAβ is mainly localized in the core of plaques, suggesting a possible role in inducing and facilitating Aβ oligomerization and accumulation. Despite this potential importance, the aggregation mechanism of pEAβ and its influence on the aggregation kinetics of other Aβ variants have not yet been elucidated. Here we show that pEAβ(3-42) forms fibrils much faster than Aβ(1-42) and the critical concentration above which aggregation was observed was drastically decreased by one order of magnitude compared to Aβ(1-42). We elucidated the co-aggregation mechanism of Aβ(1-42) with pEAβ(3-42). At concentrations at which both species do not aggregate as homofibrils, mixtures of pEAβ(3-42) and Aβ(1-42) aggregate, suggesting the formation of mixed nuclei. We show that the presence of pEAβ(3-42) monomers increases the rate of primary nucleation of Aβ(1-42) and that fibrils of pEAβ(3-42) serve as highly efficient templates for elongation and catalytic surfaces for secondary nucleation of Aβ(1-42). On the other hand, the addition of Aβ(1-42) monomers drastically decelerates the primary and secondary nucleation of pEAβ(3-42) while not altering the pEAβ(3-42) elongation rate. In addition, even moderate concentrations of fibrillar Aβ(1-42) prevent pEAβ(3-42) aggregation, likely due to non-reactive binding of pEAβ(3-42) monomers to the surfaces of Aβ(1-42) fibrils. Thus, pEAβ(3-42) accelerates aggregation of Aβ(1-42) by affecting all individual reaction steps of the aggregation process while Aβ(1-42) dramatically slows down the primary and secondary nucleation of pEAβ(3-42).
Rician Modeling and Prediction for Wireless Packet Data Systems (2008)

Wireless systems exploiting multi-user diversity require accurate channel state information. In this paper we examine channel prediction as a method to improve the performance of these systems. We model the outdoor channel by the Rician model, which combines diffuse spectra with a single specular component. Prediction accuracy is determined for the Rician model given various ratios (K factors) of specular to diffuse power. Simulation results show that accurate channel prediction further than one wavelength can be achieved at 30 dB SNR when the channel K factor is greater than ten. The predictor was evaluated on measured channels, and the Rician model was found to be appropriate as prediction intervals of the measured data are similar to those of synthetic data with same K factor. Using measurements some results regarding channel stationarity and optimal filter order are presented. We show for a proportionally fair scheduled downlink packet system that the predictor reduces fade margin at fixed packet outage leading to an improvement in throughput.
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses (2021)

Antibodies that block immune regulatory checkpoints (programmed cell death 1, PD-1 and cytotoxic T-lymphocyte-associated antigen 4, CTLA-4) to mobilise immunity have shown unprecedented clinical efficacy against cancer, demonstrating the importance of antigen-specific tumour recognition. Despite this, many patients still fail to benefit from these treatments and additional approaches are being sought. These include mechanisms that boost antigen-specific immunity either by vaccination or adoptive transfer of effector cells. Other than neoantigens, epigenetically regulated and shared antigens such as NY-ESO-1 are attractive targets; however, tissue expression is often heterogeneous and weak. Therefore, peptide-specific therapies combining multiple antigens rationally selected to give additive anti-cancer benefits are necessary to achieve optimal outcomes. Here, we show that Ropporin-1 (ROPN1) and 1B (ROPN1B), cancer restricted antigens, are highly expressed and immunogenic, inducing humoral immunity in patients with advanced metastatic melanoma. By multispectral immunohistochemistry, 88.5% of melanoma patients tested (<i>n</i> = 54/61) showed ROPN1B expression in at least 1 of 2/3 tumour cores in tissue microarrays. Antibody responses against ROPN1A and ROPN1B were detected in 71.2% of melanoma patients tested (<i>n</i> = 74/104), with increased reactivity seen with more advanced disease stages. Thus, ROPN1A and ROPN1B may indeed be viable targets for cancer immunotherapy, alone or in combination with other cancer antigens, and could be combined with additional therapies such as immune checkpoint blockade.
Extracellular membrane vesicles from umbilical cord blood‐derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning (2013)

We demonstrate by both in vitro and in vivo models accompanied with a detailed analysis of molecular characteristics that inflammatory conditioning of MSCs influence on the protein content and functional properties of MVs revealing the complexity of the MSC paracrine regulation.
Post resection circulating residual disease monitoring in early stage lung and colorectal cancer patients using a circulating cell-free DNA assay with ultra-high accuracy and specificity. (2017)

e23068 Background: Analysis of cell-free circulating tumor DNA (ctDNA) by next-generation sequencing (NGS) is a promising method for detecting and monitoring earlier stage cancers. Liquid biopsies have a large potential to detect cancer earlier upon initial recurrence and to aid in adjuvant decision making through a non-invasive and highly accurate mechanism. Methods: We developed a 30kb ctDNA capture panel based on the landscape of genomic alterations in ctDNA of over 10,000 advanced cancer patients with high theoretical clinical sensitivity for colorectal (96%) and lung (87-93%) cancers. The panel was validated with high analytical PPV (86% at MAFs &lt; 0.025%, 96% at MAFs &gt; 0.025%). We applied the panel to a clinical study of 63 healthy donors and also 40 early stage (II/III) CRC and lung cancer patients with both pre- and post-tumor resection blood draws. Tumor samples were also collected at the time of the surgical resection. Results: Overall, the detection rate of ctDNA in pre-op blood draws was 72% (13/18) in CRC and 67% (12/18) in lung cancer patients. In the post-op blood draws ctDNA was detectable in 11% (2/18) of CRC and 11% (2/18) of lung cancer cases. For lung cancer patients, the median MAF in pre-op was 0.06% (0.01%-8.47%, n = 51) and in post-op was 0.06% (0.02%-4.14%, n = 38). For CRC patients, the median MAF in pre-op was 0.18% (0.01%-9.26%, n = 51) and in post-op was 0.36% (0.04%-9.5%, n = 18). Sixty-three healthy donor plasma samples were screened at similar cfDNA input amounts and nine (14%) had mutations; the majority of the mutations were also detected in matched leukocyte DNA. To assess a clinically relevant biological false positive background rate in lung cancer patients, screening of cancer-free smokers is ongoing. Conclusions: We have developed a highly sensitive and specific universal assay for the detection of ctDNA in early stage CRC and lung cancer patients without the requirement of a priori knowledge of tumor mutations. This technology allows for a promising non-invasive route for molecular monitoring of residual disease post-surgery and for early detection of relapse compared to traditional methodologies.
α-Phosphonovinyl Carbanions in Organic Synthesis (2001)

The generation of several α-phosphono-substituted vinyl carbanions is described. The α-phosphonovinyl carbanions have been used to afford versatile vinylphosphonate reagents capable of a wide range of synthetic transformations.
Cell cycle dependence of inositol phosphate levels in neuroblastoma cells (1988)

To investigate the timing of inositol lipid turnover in relation to the cell cycle, inositol phosphates and lipids were measured in neuroblastoma (Neuro-2A) cells that were prelabeled with [3H]inositol and synchronized by a mitotic shakeoff technique. Distinct early and late phases of inositol phosphate production were identified. The early peak occurs between the 2nd and 4th hour after mitosis near the G1/S transition. A later peak occurs around the peak of S phase (DNA synthesis) at 7-8 h after mitosis. These findings suggest that activation of phosphatidylinositol turnover generates signals that play a role in cell cycle progression.