gebhart/patrepeval huggingface dataset:
Motor impairment in Wilson's disease 3: the clinical impact of pyramidal tract involvement (2009)

Magnetic brain stimulation was performed on 24 patients with Wilson's disease (WD). Responses to the right and left first dorsal interosseus muscle (FDI) and to the right and left tibialis anterior muscle (TA) were analysed. In 45% of the patients prolonged central motor conduction times (CCTs) to the FDIs were found, whereas only 12% of the patients presented with prolonged CCTs to the TA muscles. No consistent significant correlations between copper metabolism and pyramidal tract function tested by magnetic brain stimulation were found. An improvement of CCTs and response amplitudes with copper elimination therapy was observed only at early phases of therapy. There was no correlation with duration of therapy or neurological symptoms. Thus magnetic brain stimulation turns out to be sensitive to detect subclinical pyramidal tract impairment in WD but seems to test a too specific aspect of motor impairment in WD to reflect the overall neurological status of the patients. Therefore, it has to be combined with other tests to be used for therapy control.
High Thermal Stability and Rigid Rod of Novel Organosoluble Polyimides and Polyamides Based on Bulky and Noncoplanar Naphthalene−Biphenyldiamine (2005)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHigh Thermal Stability and Rigid Rod of Novel Organosoluble Polyimides and Polyamides Based on Bulky and Noncoplanar Naphthalene−BiphenyldiamineDer-Jang Liaw, Feng-Chyuan Chang, Man-kit Leung, Meng-Yen Chou, and Klaus MuellenView Author Information Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC; Department of Chemistry, National Taiwan University, Taipei, Taiwan, ROC; and Max-Planck-Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany Cite this: Macromolecules 2005, 38, 9, 4024–4029Publication Date (Web):March 30, 2005Publication History Received15 July 2004Revised18 January 2005Published online30 March 2005Published inissue 1 May 2005https://pubs.acs.org/doi/10.1021/ma048559xhttps://doi.org/10.1021/ma048559xbrief-reportACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views2332Altmetric-Citations217LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Aromatic compounds,Organic polymers,Polyimides,Polymers Get e-Alerts
Chemokine receptors on peripheral blood T lymphocytes in children on peritoneal dialysis (2020)

In conclusion, we could not confirm the phenomenon of earlier senescence of T-cells in children with CKD on PD treatment. This still requires further investigation. The higher percentage of T-cells with CCR7 surface receptor could be responsible for the increase of proliferation activity in this group of children.
Energy Regeneration From Electromagnetic Induction by Human Dynamics for Lower Extremity Robotic Prostheses (2020)

Wearable robotic devices often need electrical energy. An interesting idea is to collect mechanical energy during walking and convert it into electrical energy to recharge these devices directly. In this article, we built a light-weight robotic prosthesis (1.3 kg) with the feature of self-charging. During stance phase, the prosthetic ankle joint with damping, is driven by human dynamics. The rotated ankle joint backdrives the motor, and the motor works as a generator according to the electromagnetic induction theory. Five subjects participated in experiments to verify the feasibility and five speeds walking were studied (0.7, 0.9, 1.1, and 1.3 m/s treadmill speeds and one self-selected outdoor walking speed). Experimental results demonstrate that the electrical regenerative energy per step is 1.53 ± 0.29 J on average. Meanwhile, an average consumed energy per step of the robotic prosthesis is 4.64 ± 0.15 J, which means 33 ± 5% energy can be returned to the active prosthesis (battery, 24 V, 2.6 Ah).
Prediction of Thorough QT study results using action potential simulations based on ion channel screens (2014)

This study provides a proof-of-principle for the prediction of human TQT study results using data available early in drug development. We highlight a number of areas that need refinement to improve the method's predictive power, but the results suggest that such approaches will provide a useful tool in cardiac safety assessment.
BRACELET: Hierarchical Edge-Cloud Microservice Infrastructure for Scientific Instruments’ Lifetime Connectivity (2018)

Recent advances in cyber-infrastructure have enabled digital data sharing and ubiquitous network connectivity between scientific instruments and cloud-based storage infrastructure for uploading, storing, curating, and correlating of large amounts of materials and semiconductor fabrication data and metadata. However, there is still a significant number of scientific instruments running on old operating systems that are taken offline and cannot connect to the cloud infrastructure, due to security and performance concerns. In this paper, we propose BRACELET - an edge-cloud infrastructure that augments the existing cloud-based infrastructure with edge devices and helps to tackle the unique performance and security challenges that scientific instruments face when they are connected to the cloud through public network. With BRACELET, we put a networked edge device, called cloudlet, in between the scientific instruments and the cloud as the middle tier of a three-tier hierarchy. The cloudlet will shape and protect the data traffic from scientific instruments to the cloud, and will play a foundational role in keeping the instruments connected throughout its lifetime, and continuously providing the otherwise missing performance and security features for the instrument as its operating system ages.
Synthesis of PPAR Agonist via Asymmetric Hydrogenation of a Cinnamic Acid Derivative and Stereospecific Displacement of (S)-2-Chloropropionic Acid (2005)

The synthesis of the peroxime proliferator activated receptor (PPAR) alpha,gamma-agonist (1) was accomplished with high enantio- and diastereoselectivity by employing an asymmetric hydrogenation strategy, of an alpha-alkoxy cinnamic acid derivative, to set the C-2 chiral center. A diastereospecific S(N)2 displacement under mild basic conditions established the C-10 stereochemistry without any detectable racemization of the two epimerizable chiral centers.
Optimization of immunomagnetic separation for cord blood-derived hematopoietic stem cells (2006)

The optimized protocols enable rapid enrichment of highly pure hematopoietic stem cells from both fresh and cryopreserved cord blood.
PINE: Photonic Integrated Networked Energy efficient datacenters (ENLITENED Program) [Invited] (2020)

We review the motivation, goals, and achievements of the Photonic Integrated Networked Energy efficient datacenter (PINE) project, which is part of the Advanced Research Projects Agency–Energy (ARPA-E) ENergy-efficient Light-wave Integrated Technology Enabling Networks that Enhance Dataprocessing (ENLITENED) program. The PINE program leverages the unique features of photonic technologies to enable alternative mega-datacenters and high-performance computing (HPC) system architectures that deliver more substantial energy efficiency improvements than can be achieved through link energy efficiency alone. In phase 1 of the program, the PINE system architecture demonstrated an average factor of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mn>2.2</mml:mn></mml:mrow><mml:mo>×</mml:mo></mml:math> improvement in transactions/joule across a diverse set of HPC and datacenter applications. In phase 2, PINE will demonstrate an aggressive 1.0 pJ/bit total link budget with high-bandwidth-density dense wavelength-division multiplexing (DWDM) links to enable additional <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow class="MJX-TeXAtom-ORD"><mml:mn>2.5</mml:mn></mml:mrow><mml:mo>×</mml:mo></mml:math> or more efficiency gains through deep resource disaggregation.
In vitro mechanical evaluation of torsional loading in simulated canine tibiae for a novel hourglass-shaped interlocking nail with a self-tapping tapered locking design (2006)

Abstract Objective —To describe a novel interlocking nail (ILN) and locking system and compare the torsional properties of constructs implanted with the novel ILN or a standard 8-mm ILN (ILN8) by use of a gap-fracture model. Sample Population —8 synthetic specimens modeled from canine tibiae. Procedures —An hourglass-shaped ILN featuring a tapered locking mechanism was designed. A synthetic bone model was custom-made to represent canine tibiae with a 50-mm comminuted diaphyseal fracture. Specimens were repaired by use of a novel ILN or an ILN8 with screws. Specimens were loaded for torsional measurements. Construct compliance and angular deformation were compared. Results —Compliance of the ILN8 was significantly smaller than that of the novel ILN. Mean ± SD maximum angular deformation of the ILN8 construct (23.12 ± 0.65°) was significantly greater, compared with that of the novel ILN construct (9.45 ± 0.22°). Mean construct slack for the ILN8 group was 15.15 ± 0.63°, whereas no slack was detected for the novel ILN construct. Mean angular deformation for the ILN8 construct once slack was overcome was significantly less, compared with that of the novel ILN construct. Conclusions and Clinical Relevance —Analysis of results of this study suggests that engineering of the locking mechanism enabled the novel hourglass-shaped ILN system to eliminate torsional instability associated with the use of current ILNs. Considering the potential deleterious effect of torsional deformation on bone healing, the novel ILN may represent a biomechanically more effective fixation method, compared with current ILNs, for the treatment of comminuted diaphyseal fractures.
Sensitivity Improvement of Sample Rotation Measurement Method in HTS-SQUID Magnetometer for Diamagnetic Materials (2018)

Measuring extremely low magnetic signals of diamagnetic materials such as water and ethanol with high sensitivity is important in various fields. Ethanol is widely used as a solvent in areas such as chemical industry and drug discovery; therefore, it is important to measure its concentration with high sensitivity. We have already reported a hybrid-type magnetometer using a high temperature superconductor superconducting quantum interference device (HTS-SQUID), which can measure and evaluate magnetic characteristics by vibrating and rotating a sample. However, the signal-to-noise ratio (SNR) of the system needs to be improved as magnetic signals from diamagnetism in water and ethanol are extremely low in magnitude. In this study, digital frequency filters were applied to the signals measured by the HTS-SQUID magnetometer with a rotating sample container in order to improve the SNR of the system, and then the magnetic properties of ethanol and water were studied. As a result, the SNR of the system improved about twice the level obtained by conventional signal processing method.
Shaping field correlation with entangled quantum antennas (2017)

A quantum antenna can shape spatial entanglement of emitted photons originating from entangled states of antennas emitters. In contrast to the classical antenna, the quantum antenna can shape the second and higher order correlations without affecting amplitudes of the field. The shape and directivity of the correlations can be optimized using techniques of quantum state inference. Positive and negative correlated twin-photon, and multi-photon entangled states can be produced from the same antenna for different initial states of emitters.
Siliziumcarbid zur Amplifikation der Mikrowellenablation: In-vitro Versuche (2010)

Zielsetzung: Untersuchung des hitzemodulierenden Effekts von Siliciumcarbid (SiC) bei der Mikrowellenablation (MWA) in-vitro.
Widespread translational remodeling during human neuronal differentiation (2017)

Abstract Faithful cellular differentiation requires precise coordination of changes in gene expression. However, the relative contributions of transcriptional and translational regulation during human cellular differentiation are unclear. Here, we induced forebrain neuronal differentiation of human embryonic stem cells (hESCs) and characterized genomewide RNA and translation levels during neurogenesis. We find that thousands of genes change at the translation level across differentiation without a corresponding change in RNA level. Specifically, we identify mTOR complex 1 signaling as a key driver for elevated translation of translation-related genes in hESCs. In contrast, translational repression in active neurons is mediated by transcript 3′ UTRs, through regulatory sequences. Together, our findings identify a functional role for the dramatic 3′ UTR extensions that occur during brain development, and provide insights to interpret genetic variants in post-transcriptional control factors that influence neurodevelopmental disorders and diseases.
Improved Measurement of the Hydrogen1S–2STransition Frequency (2011)

We have measured the 1S-2S transition frequency in atomic hydrogen via two-photon spectroscopy on a 5.8 K atomic beam. We obtain f(1S-2S) = 2,466,061,413,187,035 (10) Hz for the hyperfine centroid, in agreement with, but 3.3 times better than the previous result [M. Fischer et al., Phys. Rev. Lett. 92, 230802 (2004)]. The improvement to a fractional frequency uncertainty of 4.2 × 10(-15) arises mainly from an improved stability of the spectroscopy laser, and a better determination of the main systematic uncertainties, namely, the second order Doppler and ac and dc Stark shifts. The probe laser frequency was phase coherently linked to the mobile cesium fountain clock FOM via a frequency comb.
Large Deviations for Products of Non-I.i.d. Stochastic Matrices with Application to Distributed Detection (2018)

We derive the large deviation rate for convergence in probability of products of independent but not identically distributed stochastic matrices arising in time-varying distributed consensus-type networks. More precisely, we consider the model in which there exists a baseline topology that describes all possible communications and nodes are activated sparsely. At any given time, a node is active with a certain time-dependent probability, and any two nodes communicate if they are both active at that time. Under this model, we compute the exact rate for exponential decay of probabilities that the matrix products stay bounded away from their limiting matrix. We show that the rate is given by the minimal vertex cut of the baseline topology, where the node costs are defined by their limiting activation probabilities. The computed rate has many potential applications in distributed inference with intermittent communications. We provide an application in the context of consensus+innovations distributed detection. Therein, we show that optimal error exponent is achievable under a very general model of sparsified activations, thus effectively constructing asymptotically optimal detectors with significant communications savings.
32 × 32 Pixelated High-Power Flip-Chip Blue Micro-LED-on-HFET Arrays for Submarine Optical Communication (2021)

This work proposes the use of integrated high-power InGaN/GaN multiple-quantum-well flip-chip blue micro light-emitting diode (μ-LED) arrays on an AlGaN/GaN-based heterojunction field-effect transistor (HFET), also known as a high electron mobility transistor (HEMT), for various applications: underwater wireless optical communication (UWOC) and smart lighting. Therefore, we demonstrate high-power μ-LED-on-HEMT arrays that consist of 32 × 32 pixelated μ-LED arrays and 32 × 32 pixelated HEMT arrays and that are interconnected by a solder bump bonding technique. Each pixel of the μ-LED arrays emits light in the HEMT on-state. The threshold voltage, the off-state leakage current, and the drain current of the HEMT arrays are -4.6 V, <~1.1 × 10<sup>-9</sup> A at gate-to-source voltage (<i>V<sub>GS</sub></i>) = -10 V, and 21 mA at <i>V<sub>GS</sub></i> = 4 V, respectively. At 12 mA, the forward voltage and the light output power (LOP) of μ-LED arrays are ~4.05 V and ~3.5 mW, respectively. The LOP of the integrated μ-LED-on-HEMT arrays increases from 0 to ~4 mW as the <i>V<sub>GS</sub></i> increases from -6 to 4 V at <i>V<sub>DD</sub></i> = 10 V. Each pixel of the integrated μ-LEDs exhibits a modulated high LOP at a peak wavelength of ~450 nm, showing their potential as candidates for use in UWOC.
Detection and sequence analysis of tryptic peptides by microcolumn liquid chromatography‐tandem mass spectrometry using an electrospray interface (1990)

Abstract Fused‐silica packed LC capillaries were interfaced with a triple quadrupole mass spectrometer through the electrospray ionization device. The coupling of these powerful techniques is suitable for structural characterization of constituents of peptide maps generated at high sensitivity. Sequence determinations appear possible at the femtomole level following this approach.
Slow Conformational Dynamics at C2′-endo Nucleotides in RNA (2020)

RNA molecules undergo local conformational dynamics on timescales spanning picoseconds to minutes. Slower local motions have the greater potential to govern RNA folding, ligand recognition, and ribonucleoprotein assembly reactions but are difficult to detect in large RNAs with complex structures. RNA SHAPE chemistry employs acylation of the ribose 2'-hydroxyl position to measure local nucleotide flexibility in RNA and is well-characterized by a mechanism in which each nucleotide samples unreactive (closed) and reactive (open) states. We monitor RNA conformational dynamics over distinct time domains by varying the electrophilicity of the acylating reagent. Select C2'-endo nucleotides are nonreactive toward fast reagents but reactive toward slower SHAPE reagents in both model RNAs and in a large RNA with a tertiary fold. We conclude, first, that the C2'-endo conformation by itself does not govern SHAPE reactivity. However, some C2'-endo nucleotides undergo extraordinarily slow conformational changes, on the order of 10(-4) s(-1). Due to their distinctive local dynamics, C2'-endo nucleotides have the potential to function as rate-determining molecular switches and are likely to play central, currently unexplored, roles in RNA folding and function.
Nomogram to Predict Insignificant Prostate Cancer at Radical Prostatectomy in Korean Men: A Multi-Center Study (2010)

Our current nomogram provides sufficiently accurate information in clinical practice that may be useful to patients and clinicians when various treatment options for screen-detected prostate cancer are considered.
Identification and Enantiodivergent Synthesis of (5Z,9S)-Tetradec-5-en-9-olide, a Queen-Specific Volatile of the Termite Silvestritermes minutus (2018)

The queens of social insects differ from sterile colony members in many aspects of their physiology. Besides adaptations linked with their specialization for reproduction and extended lifespan, the queens also invest in the maintenance of their reproductive dominance by producing exocrine chemicals signaling their presence to the nestmates. The knowledge of the chemistry of queen-specific cues in termites is scarce. In addition to the contact recognition based on cuticular hydrocarbons, long-range signals mediated by volatiles are expected to participate in queen signaling, especially in populous colonies of higher termites (Termitidae). In queens of the higher termite Silvestritermes minutus (Syntermitinae), we have detected a previously undescribed volatile. It is present in important quantities on the body surface and in the headspace, ovaries, and body cavity. MS and GC-FTIR data analyses led us to propose the structure of the compound to be a macrolide 10-pentyl-3,4,5,8,9,10-hexahydro-2 H-oxecin-2-one. We performed enantiodivergent syntheses of two possible enantiomers starting from enantiopure ( S)-glycidyl tosylate. The synthetic sequence involved macrolide-closing metathesis quenched with a ruthenium scavenging agent. The absolute and relative configuration of the compound was assigned to be (5 Z,9 S)-tetradec-5-en-9-olide. Identification and preparation of the compound allow for investigation of its biological significance.
Quantitative Cherenkov emission spectroscopy for tissue oxygenation assessment (2012)

Measurements of Cherenkov emission in tissue during radiation therapy are shown to enable estimation of hemoglobin oxygen saturation non-invasively, through spectral fitting of the spontaneous emissions from the treated tissue. Tissue oxygenation plays a critical role in the efficacy of radiation therapy to kill tumor tissue. Yet in-vivo measurement of this has remained elusive in routine use because of the complexity of oxygen measurement techniques. There is a spectrally broad emission of Cherenkov light that is induced during the time of irradiation, and as this travels through tissue from the point of the radiation deposition, the tissue absorption and scatter impart spectral changes. These changes can be quantified by diffuse spectral fitting of the signal. Thus Cherenkov emission spectroscopy is demonstrated for the first time quantitatively in vitro and qualitatively in vivo, and has potential for real-time online tracking of tissue oxygen during radiation therapy when fully characterized and developed.
Supplementary Figure S3 from A Clinical PET Imaging Tracer ([<sup>18</sup>F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma (2023)

&lt;p&gt;Evaluation of PKM2 expression in U87-GFP/luc orthotopic GBM&lt;/p&gt;
ChemInform Abstract: Diels‐Alder Reaction of 2‐Amino‐Substituted Furans as a Method for Preparing Substituted Anilines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tenacious Endemic Typhoid Fever in Samoa (2020)

Typhoid has been endemic in Samoa in the period 2008-2019. Interventions, including mass vaccination with a Vi-conjugate vaccine coadministered with measles vaccine are planned.