gebhart/patrepeval huggingface dataset:
A Randomized, Double‐blind, Placebo‐controlled Trial to Evaluate Efficacy and Tolerability of an Optimized Botanical Combination in the Management of Patients with Primary Hypercholesterolemia and Mixed Dyslipidemia (2011)

This study compared the efficacy and tolerability of an optimized botanical combination containing policosanol, tomato extract, orally bioavailable grape procyanidins and Oenothera biennis oil against placebo in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Such a combination is endowed with biological properties targeted to cholesterol control and vasoprotection. This randomized, double-blind, parallel-group trial consisted of a 6 week treatment period following 4 week baseline period, and a 2 week post-treatment follow-up. At baseline, both the groups were comparable to each other. Both the active treatment and the placebo group included 30 patients (active treatment: mean age 46.80 ± 7.43 years, nine males; placebo: mean age 45.50 ± 6.76 years, eight males). Significant reductions in the LDL-cholesterol (LDL-C; -17.33% from baseline, p < 0.001) and total cholesterol (TC; -13.38% from baseline, p < 0.0001) values over the treatment period were observed with the tested product. The treatment also resulted in reductions in C-reactive protein (CRP), malondialdehyde (MDA) and superoxide dismutase (SOD) values, which are indices of oxidative stress. This rational combination of different compounds is effective and safe in lowering the elevated LDL-C and TC values. It is also effective in the modulation of the oxidation indices values; however, a further long term study in a larger population would be needed in order to confirm these preliminary findings.
200&#x00B0;C direct bonding copper interconnects : Electrical results and reliability (2012)

Copper direct bonding is one of the most promising approaches for three dimensional integrated circuits (3D IC). This process has reached a maturity already reported in publications for wafer to wafer and die to wafer stacking. Anyway, its reliability has to be demonstrated. In this paper Electromigration (EM) and Stress Induced Voiding (SIV) tests are also performed on 200°C bonded daisy chains to investigate the reliability behaviour of such structures, first electrical tests on bonded dies is also reported.
(Student Battery Slam Best Presentation Award Winner) Enhancing the Stability of the Electrode/Electrolyte Interface in Solid State Li-Ion Batteries (2021)

All-solid-state Lithium-ion batteries (LIBs) based on solid ceramic electrolytes are a promising next-generation energy storage technology for high energy density and enhanced cycle life. A key requirement for such batteries is packing high energy in low form factor (i.e. in thin-film form) to increase both the gravimetric and volumetric energy densities. Lithium superionic conducting (LISICON) solid electrolytes are prominent candidates among liquid, gel, polymer and solid electrolytes that can enable safety and optimum performance in a high energy density battery with thin-film cell components. One particular LISICON material, lithium aluminum germanium phosphate (LAGP), is a promising solid-electrolyte due to its high ionic conductivity (~ 5 mS/cm at 23 °C), high electrochemical stability window (&gt; 5V), and single Li + ion conduction (high transference number, low porosity mitigating dendrite propagation), enabling a high energy battery and mitigating safety and packaging issues of conventional LIBs. However, most solid electrolytes, suffer from low chemical stability with the lithium (Li) anode. This is especially true for LAGP, with such chemical instability invariably leading to the formation of a highly resistive electrode/electrolyte interface which is detrimental for high power and cell longevity. Therefore, despite the promise of solid ceramic electrolytes for next-generation solid-state LIBs, if they are to be practical for use in solid-state LIBs with Li metal anodes, it is very important to design a chemically stable interface with kinetically efficient charge transport processes (i.e. Li + transport). In order to enhance the chemical stability of the electrode/electrolyte interface, we identified lithium compatible materials (such as thin film of lithium phosphorus oxynitride (LIPON), gold (Au), carbon nanotube (CNT) layer, aluminium oxide (Al 2 O 3 ) and suitable methods to apply them at the Li metal/LAGP interface. The evolution of the interfacial resistance as a function of time was monitored using Electrochemical Impedance Spectroscopy (EIS). We will present data showing that the application of the lithium-compatible, thin film interfacial layer, results in enhanced stability and a significant reduction in resistance compared with the unmodified Li metal/LAGP interface, offering an interfacial engineering approach for improved performance of an all-solid-state LIB.
Energy Saving RTS-TMP Puloing and its Pulp Quality (2003)

RTSTM is a new Low Retention, High Temperature and High Speed TMP pulping method developed by Andritz. While the pulp quality is kept the same as conventional TMP, the energy is 15-17% less than the conventional TMP.Extensive studies were conducted to evaluate the development of pine pulp properties and energy requirements using two different thermomechanical refining processes at a southern U. S. paper mill.The processes included both a low intensity (TMP) and a high intensity (RTSTM) refining configuration. The pulps produced with the RTS process had 15%-17% lower energy consumption compared to TMP pulps produced at similar freeness and handsheet physical properties. Despite similar average fiber length results between the two processes, the low intensity pulps had a higher percent by weight of fiber retained on the Bauer McNett 14/28 fractions, whereas the high intensity pulps had a higher percent by weight retained on the middle fractions. Calendered newsprint produced from the high intensity pulp had a lower roughness, which may be related to the lower fiber size distribution. Light was thrown on this finding by porometry measurements of the newsprint, which revealed a slightly lower pore size distribution from paper produced with the higher intensity pulp. Standard ink printing tests, however, provided similar results between newsprint paper produced from the TMP and RTSTM processes.
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE (2022)

Bacteria produce a remarkably diverse range of glycoside hydrolases to metabolize glycans from the environment as a primary source of nutrients, and to promote the colonization and infection of a host. Here we focus on EndoE, a multi-modular glycoside hydrolase secreted by Enterococcus faecalis, one of the leading causes of healthcare-associated infections. We provide X-ray crystal structures of EndoE, which show an architecture composed of four domains, including GH18 and GH20 glycoside hydrolases connected by two consecutive three α-helical bundles. We determine that the GH20 domain is an exo-β-1,2-N-acetylglucosaminidase, whereas the GH18 domain is an endo-β-1,4-N-acetylglucosaminidase that exclusively processes the central core of complex-type or high-mannose-type N-glycans. Both glycoside hydrolase domains act in a concerted manner to process diverse N-glycans on glycoproteins, including therapeutic IgG antibodies. EndoE combines two enzyme domains with distinct functions and glycan specificities to play a dual role in glycan metabolism and immune evasion.
Data-Driven Design Optimization for Composite Material Characterization (2011)

Abstract The main goal of the present paper is to demonstrate the value of design optimization beyond its use for structural shape determination in the realm of the constitutive characterization of anisotropic material systems such as polymer matrix composites with or without damage. The approaches discussed are based on the availability of massive experimental data representing the excitation and response behavior of specimens tested by automated mechatronic material testing systems capable of applying multiaxial loading. Material constitutive characterization is achieved by minimizing the difference between experimentally measured and analytically computed system responses as described by surface strain and strain energy density fields. Small and large strain formulations based on additive strain energy density decompositions are introduced and utilized for constructing the necessary objective functions and their subsequent minimization. Numerical examples based on both synthetic (for one-dimensional systems) and actual data (for realistic 3D material systems) demonstrate the successful application of design optimization for constitutive characterization.
Geometric interpretation of multiaccess joint detection and the alternating projection algorithm (2002)

The joint detection of all users in a multiple access (MA) communication system in which user transmissions are correlated has been shown in recent literature to enhance the system performance relative to that achieved without joint detection. Over the past several years the area of low complexity joint detectors has received much attention. This paper explains the problem of multiple access joint detection in geometrical terms. Geometric interpretation leads to the proposal of an alternating projection joint detection algorithm (APJD). Due to some similarities between our APJD and the multistage joint detector (MJD) of Varansi and Aazhang (1990), the MJD is also discussed. The APJD is guaranteed to converge and a proof is given. The geometric interpretation of the MA joint detection problem allows for the exploration of determining, a priori, the error probability of a joint detector and user waveform set in the absence of noise. Simulations offer empirical characterization of the error behavior of both detectors.
Time course of lesion development in the hairless guinea‐pig model of sulfur mustard‐induced dermal injury (2011)

The objective of these studies was to provide detailed analyses of the time course of sulfur mustard (SM) vapor-induced clinical, histological, and biochemical changes following cutaneous exposure in hairless guinea-pigs. Three 6 cm(2) sites on the backs of each guinea-pig were exposed to SM vapor (314 mg(3) ) for 6 minutes (low dose) or 12 minutes (high dose). Animals were killed at 6, 24, and 48 hours, or 2 weeks postexposure. Erythema, edema, histopathology, and analysis of matrix metalloproteinase (MMP)-2 and -9 content were evaluated. Erythema was observed by 6 hours, and edema by 24 hours postexposure. Vapor exposure caused epidermal necrosis with varying degrees of dermatitis, ulceration, hemorrhage, and separation of the dermis from the epidermis. Later changes included epidermal regeneration with hyperplasia and formation of granulation tissue in the dermis with loss of hair follicles and glandular structures. Relative amounts of pro and active MMP-2 and MMP-9 were significantly increased in the high-dose SM group at 2 weeks. Erythema, edema, and histologic changes are consistent with findings among human victims of SM attack. This model, with observations to 2 weeks, will be useful in assessing the efficacy of countermeasures against SM.
ChemInform Abstract: Synthesis and Biological Activities of a New Set of Irreversibly Acting 2‐(4′‐Isothiocyanatobenzyl)imidazoline Analogues in Rat Thoracic Aorta. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Mycophenolic Acid. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Per-user policy enforcement on mobile apps through network functions virtualization (2014)

Due to the increasing popularity of smartphones and tablets, mobile apps are becoming the preferred portals for users to access various network services in both residential and enterprise environments. Predominantly using generic HTTP or HTTPS protocols, traffic from different mobile apps is largely indistinguishable. This loss of visibility into mobile app traffic brings new challenges to network management and traffic analysis. It has became very hard to implement network policies based on the differentiation between traffic from compliant and non-compliant mobile apps. This paper presents a system that not only provides network administrators the much desired capability of enforcing policies on mobile app traffic, but also does that at a fine per-user granularity. The proposed system takes a Network Functions Virtualization (NFV) approach and virtualizes an edge router into multiple virtual data planes. Specifically, each data plane serves solely to one particular user and consists of user-specific virtualized network functions. The independence of the virtual data planes facilitates enforcing network policies at the per-user level. To enable policy enforcement on mobile apps, our system includes a sophisticated mobile app identification module to recognize traffic from different apps using preloaded traffic signatures. By exploiting TLS proxying, our system can even enforce policies on those mobile apps adopting traffic encryption. We have implemented a prototype of the proposed system as a wireless access point (AP) using a commodity small form factor PC. Our preliminary experimental evaluations show that the system can scale to modest number of users without much impacting user experience in using the network.
Prevalence and risk factors of cardiac thrombus prior to ventricular tachycardia catheter ablation in structural heart disease (2022)

Cardiac thrombus can be identified in 11% of patients referred for scar-related VT ablation. These findings underscore the importance of systematic thrombus screening to minimize embolic risk.
Time-resolved x-ray photoabsorption and diffraction on timescales from ns to fs (2000)

Time-resolved x-ray diffraction with picosecond time resolution is used to observe scattering from coherent acoustic phonons in laser-excited InSb crystals. The observed oscillations in the crystal reflectivity are in agreement with a model based on dynamical diffraction theory. Synchrotron radiation pulses of ∼300 fs in duration have been generated by femtosecond laser pulses modulating the electron beam in the Advanced Light Source.
A model for thermal ablation of biological tissue using laser radiation (1987)

We present a theory of thermal laser ablation based on the heat equation and on an energy balance equation derived from it. Ablation is assumed to be brought about by the heating and evaporation of tissue water. The model is three-dimensional, and scattering and the water-steam phase transition are explicitly taken into account. The model predicts threshold parameters and a steady-state ablation velocity in terms of the optical and thermal properties of the tissue and the laser beam intensity and spot diameter.
[Adhesion of composite to dentin. Mechanical and clinical results]. (1993)

Although an efficient bond of resin composites to enamel can be realized since quite a long time, reliable dentine bonding is nowadays still a clinical problem. After the failure of the dentine-etch technique, followed by the misfortunes of the chemical dentine adhesion technique, modern dentine adhesive systems are believed to function by a micromechanical attachment mechanism. Based on a morphological study of the resin-dentine interface, a broad selection of dentine adhesive systems was classified following their adhesion-strategy. In a second part, eight dentine adhesive systems were clinically tested in terms of retention.
Identification and Characterization of a cDNA for Mouse Ameloblastin (1998)

Ameloblastin was first identified as one of the most abundant novel transcripts from a random screening of a rat incisor cDNA library. In situ hybridization experiments have shown ameloblastin expression to be specific to ameloblasts, with highest levels in secretory and maturation stage ameloblasts and cells of the epithelial root sheath. Ameloblastin has been identified as a candidate gene for the local hypoplastic form of autosomal dominant amelogenesis imperfecta, by virtue of it's location within the critical disease locus. The purpose of this study was to isolate a full length mouse ameloblastin cDNA and determine its temporal expression pattern during odontogenesis. A newborn mouse molar cDNA library was screened using a rat ameloblastin cDNA probe. Positive clones were confirmed by PCR analysis with ameloblastin-specific primers, and their size determined with vector-specific primers. Phage clones were rescued to phagemid using Exassist helper phage and the nucleotide sequence determined. We report here the identification of two clones, exhibiting alternative splicing of the putative open reading frame, and use of multiple polyadenylation signals. Nucleotide sequence analysis indicated a high degree of similarity to rat ameloblastin, rat amelin 1 and 2 and porcine sheathlin. Reverse transcriptase-PCR analysis using mouse first and second mandibular molar mRNA indicated initial expression at E-14. This is one day after the initial expression of tuftelin (E-13) and one day prior to that of amelogenin (E-15).
Supplementary Figure 6 from <i>miR-152</i> Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer (2023)

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Infrared scattering scanning near-field optical microscopy using an external cavity quantum cascade laser for nanoscale chemical imaging and spectroscopy of explosive residues (2013)

Infrared scattering scanning near-field optical microscopy (s-SNOM) is an apertureless superfocusing technique that uses the antenna properties of a conducting atomic force microscope (AFM) tip to achieve infrared spatial resolution below the diffraction limit. The instrument can be used either in imaging mode, where a fixed wavelength light source is tuned to a molecular resonance and the AFM raster scans an image, or in spectroscopy mode where the AFM is held stationary over a feature of interest and the light frequency is varied to obtain a spectrum. In either case, a strong, stable, coherent infrared source is required. Here we demonstrate the integration of a broadly tunable external cavity quantum cascade laser (ECQCL) into an <i>s</i>-SNOM and use it to obtain infrared spectra of microcrystals of chemicals adsorbed onto gold substrates. Residues of the explosive compound tetryl was deposited onto gold substrates. <i>s</i>-SNOM experiments were performed in the 1260-1400cm<sup>-1</sup> tuning range of the ECQCL, corresponding to the N0<sub>2</sub> symmetric stretch vibrational fingerprint region. Vibrational infrared spectra were collected on individual chemical domains with a collection area of ~500 nm<sup>2</sup> and compared to ensemble averaged far-field reflection-absorption infrared spectroscopy (RAIRS) results.
Atomic Crosschain Transactions for Ethereum Private Sidechains (2021)

The Atomic Crosschain Transaction for Ethereum Private Sidechains protocol allows composable programming across permissioned Ethereum blockchains. It allows for inter-contract and inter-blockchain function calls that are both synchronous and atomic: if one part fails, the whole call tree of function calls is discarded. The protocol is not based on existing techniques such as Hash Time Locked Contracts, relay chains, block header transfer, or trusted intermediaries. It uses (a) threshold signatures to prove values across blockchains, (b) coordination contracts to manage the state of crosschain transactions, and (c) a function call tree commitment scheme to allow users to commit to a call tree and then later check that the correct function calls have been executed. This paper analyses the processing overhead of using this technique compared to using multiple standard non-atomic single blockchain transactions. The additional processing is analysed for four scenarios involving multiple blockchains: a Trade–Finance system, the Hotel–Train problem, a Supply Chain with Provenance, and an Oracle. The protocol is shown to have both safety and liveness properties.
The influence of hip circumference on the relationship between abdominal obesity and mortality (2012)

The effect of central obesity on mortality risk is seriously underestimated without adjustment for hip circumference. Adding waist and hip circumference to a Framingham-type model for CVD mortality substantially increased predictive power. Both may be important inclusions in CVD risk prediction models.
ChemInform Abstract: Synthesis of β‐C‐Glycosides of N‐Acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ternary Porphyrinato HfIV and ZrIV Polyoxometalate Complexes (2009)

We report a facile, high yield synthesis and characterization of discrete, ternary porphyrin-metal-polyoxometalate (Por-M-POM) complexes where a group (IV) transition metal ion is bound both to the porphyrin core and to the lacunary site of a Keggin POM, PW(11)O(39) (-7). The remarkably robust complexes exploit the fact that Hf(IV) and Zr(IV) are 7-8 coordinate and reside outside the plane of the porphyrin macrocycle, thus enabling the simultaneous coordination to meso-tetraphenylporphyrin (TPP) or meso-tetra(4-pyridyl)porphyrin (TPyP) and to the defect site in the Keggin framework. The physical properties of the (TPP)Hf(PW(11)O(39))[TBA](5), (TPyP)Hf(PW(11)O(39))[TBA](5), and (TPP)Zr(PW(11)O(39))[TBA](5) complexes are similar because the metal ions have similar oxidation states, and coordination chemistry.This architecture couples the photonic properties of the porphyrin to the POM because the metal ion is incorporated into both frameworks. Thus the ternary complexes can serve as a basis for the characterization of Hf(IV) and Zr(IV) porphyrins bound to oxide surfaces via the group (IV) metal ions. The Hf(Por) and Zr(Por) bind strongly to TiO(2) nanoparticles and indium tin oxide (ITO) surfaces, but significantly less binds to crystalline SiO(2) or TiO(2) surfaces. Together, the strong binding of the metalloporphyrins to the POM, nanoparticles, and the ITO surfaces, and paucity of binding to crystalline surfaces, suggests that the 3-4 open coordination sites on the Hf(Por) and Zr(Por) are predominantly bound at surface defect sites.
Reconfiguration in Argus (1992)

Early work on reconfiguration of distributed applications was done as part of the Argus project at MIT. The authors review that work, examine the lessons that they learned, and relate their Argus experience to current plans for building Thor: a distributed, highly-available object database management system. They emphasize the type system, communication model, and persistence model of Argus, and the interaction of those models with reconfiguration requirements. >