gebhart/patrepeval huggingface dataset:
Silicon-Microresonator-Based Mid-Infrared Dual-Comb Source (2016)

We demonstrate a microresonator-based dual-comb source. Operation is achieved in the mid-infrared with a single continuous-wave pump source using two silicon microresonators that are each modelocked using thermal control and free-carrier injection.
Multicentric reticulohistiocytosis associated with Burkitt lymphoma and adenocarcinoma. (2008)

Multicentric reticulohistiocytosis (MRH) is a rare disease of unknown etiology characterized by cutaneous nodules and destructive, sometimes crippling, polyarthritis. The diagnosis is confirmed by histopathologic features of the cutaneous nodules or synovial tissue, including an infiltrate composed of histiocytes, many of them multinucleate, with a ground glass appearance. Multicentric reticulohistiocytosis has been associated with a number of chronic conditions and various malignancies. We report a case of MRH in a patient with Burkitt lymphoma and metastatic adenocarcinoma of the gastrointestinal tract.
Inter- and Intramolecular Thermal Activation of sp3 C−H Bonds with Ruthenium Bisallyl Complexes (1999)

Complexes of type [{R2P(CH2)nPR2}Ru(2-Me-all)2] (2-Me-all = 2-methylpropenyl; R = Cy, n = 1−3, 5a−c; R = Me, n = 2, 6; R2 = −(CH2)4−, n = 2, 7) have been synthesized from the reaction of the corresponding electron-rich diphosphines with [(cod)Ru(2-Me-all)2] (4) at 50−70 °C. The new complexes were fully characterized by multinuclear NMR spectroscopy and mass spectroscopic techniques. Reacting 4 with Cy2P(CH2)nPCy2 containing hydrocarbon bridges with n = 3 (1c) and n = 4 (1d) at 95 and 50 °C, respectively, led to [κ2P,P‘-{(η3-C6H8)CyP(CH2)nPCy2}Ru(η3-C8H13)] (n = 3, 4; 8c,d) via intramolecular C−H bond activation and concomitant hydride transfer to cyclooctadiene. The molecular structure of 8c was unambiguously assigned by multinuclear 1D and 2D NMR spectroscopy and confirmed by single-crystal X-ray diffraction. The new complexes were tested as homogeneous catalyst precursors in thermal intermolecular C−H activation processes. In dehydrogenation of cyclooctane (coa), an initial turnover frequency of 1.9 h-1 was observed using complex 5a under refluxing conditions without the need of a hydrogen scavenger. A maximum total number of 5 catalytic turnovers was achieved after 48 h. Ligand degradation by dehydrogenation was detected under catalytic conditions, presumably initiated via intramolecular C−H activation as in species of type 8. Attempts to utilize complexes 5 for C−H activation in scCO2 as the reaction medium resulted in insertion of CO2 into the Ru−allyl moiety, yielding catalytically inactive ruthenium carboxylates.
Elastic stability of high coupling ternary single crystals (2013)

A sub-hertz harmonic force was used to investigate the elastic response of ternary (1-y-x)Pb(In1/2Nb1/2)O3-yPb(Mg1/3Nb2/3)O3-xPbTiO3 (PIN-PMN-PT) single crystal with compositions (x = 0.30 and x = 0.33) near the Morphotropic Phase Boundary (MPB) under isothermal and zero-field conditions. The observed instability under mechanical compression is attributable to a ferroelectric rhombohedral FR-ferroelectric orthorhombic FO phase transformation. The associated strain is a function of proximity to MPB and is consistent with the prediction of the classical Devonshire theory. Isothermal resonance-antiresonance frequency sweeps versus temperature revealed a non-vertical MPB with (∂TRT/∂x)&amp;lt;0, where TRT is the rhombohedral-tetragonal transition temperature. These results provide insights into the role of PT content on the stability of PIN-PMN-PT crystals used for electromechanical devices and sound projectors.
<title>Random encoded reference beam for secure data storage in a holographic memory</title> (2000)

A method is presented to store biometric and/or other important information on an ID card in the form of a Card Hologram that cannot be read or duplicated without the use of a special Key Hologram that is secured inside of an automated reader. The Key Hologram produces the unique wavefront required to release the information contained in a complex, 3- D diffraction pattern recorded in a volume hologram attached to the card. Experimental results are presented in which the image of an Air Force resolution target are recorded and reconstructed in a volume material using a random speckle wavefront and that cannot be viewed using a simple wavefront such as a collimated or diverging laser beam.
Rituximab monotherapy is effective in patients with poor risk refractory aggressive non-Hodgkin's lymphoma. (2004)

We report the results of rituximab monotherapy in 21 patients with refractory or relapsed aggressive non Hodgkin s lymphoma (NHL). The majority of the patients (16/21) were refractory to conventional treatment and not eligible for high dose chemotherapy. Responses (1 complete and 6 partial) were achieved in some of these patients and their median overall survival was 8 months.
High temperature mechanical behavior of porous ceria and ceria‐based solid‐oxide fuel cells (2019)

Abstract Multiple environment mechanical testing of solid‐oxide fuel cells (SOFCs) and SOFC materials is critical to ensure appropriate compressive sealing in stack designs. Establishing the effects of temperature, environment, and porosity on the flexural strength of ceria‐based SOFCs is a significant step toward practical deployment of the technology. This article presents research into these properties by use of a temperature and atmosphere controlled 3‐point bend fixture capable of reaching Intermediate Temperature (IT)‐SOFC operating conditions (650°C). Gadolinium‐doped ceria (GDC) samples with varying porosity and pore geometry were tested and it was determined that more spherical porosity contributed to improved flexural strength as compared with higher aspect ratio porosity. A linear strengthening effect was also observed with increasing temperature from ambient to 650°C for GDC‐based anode support layers and half‐cell samples. Scanning electron microscopy was performed on fracture surfaces to identify fracture modes and to examine internal pore structures. Directionality of the applied stress with respect to the layered microstructure was found to have no measurable impact on mechanical properties in air, but orientation had a significant impact on strength of cells with reduced anodes. Additionally, with the support of thermogravimetric analysis, it was determined that after reduction, exposure to oxygen below 100°C does not influence mechanical properties of the cells.
RTCA SC-159: 30 Years of Aviation GPS Standards (2015)

This paper summarizes the accomplishments of RTCA, Inc.’s Special Committee 159 (SC-159) over the past 30 years including the many documents that SC-159 has produced. The paper emphasizes the importance of these documents towards the adoption of the Global Positioning System (GPS) for civil aviation applications through their widespread use by the Federal Aviation Administration (FAA), other civil aviation authorities, the International Civil Aviation Organization (ICAO), and other organizations. Lastly, the paper describes a recently approved update to SC-159’s Terms of Reference for new products to be developed from the present time through 2023.
Inhibition of Telomerase Recruitment and Cancer Cell Death (2013)

Continued proliferation of human cells requires maintenance of telomere length, usually accomplished by telomerase. Telomerase is recruited to chromosome ends by interaction with a patch of amino acids (the TEL patch, for TPP1 glutamate (E) and leucine (L)-rich patch) on the surface of telomere protein TPP1. In previous studies, interruption of this interaction by mutation prevented telomere extension in HeLa cells, but the cell culture continued to grow. We now show that the telomerase inhibitor BIBR1532 acts together with TEL patch mutations to inhibit the growth of HeLa cell lines and that apoptosis is a prominent mechanism of death of these cells. Survivor cells take over the population beginning around 40 days in culture. These cells no longer express the TEL patch mutant TPP1, apparently because of silencing of the expression cassette, a survival mechanism that would not be available to cancer cells. These results provide hope that inhibiting the binding of telomerase to the TEL patch of TPP1, perhaps together with a modest inhibition of the telomerase enzyme, could comprise an effective anticancer therapy for the ∼90% of human tumors that are telomerase-positive.
AUA-recommended Antibiotic Prophylaxis for Primary Penile Implantation Results in a Higher, Not Lower, Risk for Postoperative Infection: A Multicenter Analysis (2022)

Vancomycin + gentamicin alone for antibiotic prophylaxis for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard antibiotic regimens while antifungal use is associated with lower infection risk. A critical review of the recommended antimicrobial prophylactic regimens is needed. Prospective research is needed to further elucidate best practices in inflatable penile prosthesis antimicrobial prophylaxis.
Abstract 3515: LHX9 is a novel oncogene bypassing KRAS addiction (2017)

Abstract Background Oncogenic mutations of RAS are detected in approximately 30% of human cancers. KRAS is highly mutated in pancreatic, colorectal and lung cancers. Direct therapeutic targeting of Ras and its membrane association has been challenging due to high affinity of GTP to Ras and unexpected mechanism of alternative post-translational modification. While few inhibitors of downstream RAS effectors - MAPK and PI3K pathways - show some clinical efficacy, they are complicated by complex feedback loops, and as single agents are not effective in KRAS-mutant cancers. Combination therapies may be promising yet limited by narrow therapeutic window. Identification of alternative strategies to directly inhibiting RAS and MAPK/PI3K pathways is key to address this unmet need. Methods To this end, we performed a genome-scale open reading frames screen to identify genes capable of restoring viability to KRAS-dependent cells following KRAS suppression. We tested the top 5-standard-deviation hits in low-throughput manner. One of the top hits included LIM homeobox 9 (LHX9), a homeobox family transcription factor essential for mouse gonad, limb, and brain development. While LHX9 is amplified in several cancers, little is known regarding its roles in cancers. We used hypothesis-driven as well as unbiased approaches including RNA-seq, ChIP-seq, and IP-mass spectrometry to investigate the basis of LHX9-mediated bypass of KRAS dependency. Results We showed that LHX9 rescued KRAS suppression in multiple cell lines as well as xenograft. LHX9 overexpression substituted for KRAS in KRAS-driven xenograft. Moreover, in activated-MEK-overexpressing HA1E cells, LHX9 formed tumors as robustly as myristoylated AKT. LHX9 rescued KRAS suppression by both restoring KRAS-dependent pathways and activating KRAS-independent pathways. First, LHX9 reactivated the main KRAS effectors - MAPK and PI3K pathways and conferred resistance to MEK inhibitor Trametinib. Second, using ChIP- and RNA-seq, we observed LHX9 binding to promoters/enhancers of genes whose expression was regulated by KRAS, particularly YAP1. Third, LHX9 increased expression and activation of KRAS-independent genes, including STAT3. Conclusions Here, we identified LHX9 as a novel bypass of KRAS addiction. Multiple unbiased approaches revealed at least three mechanisms by which LHX9 rescued KRAS suppression. Our findings contribute to our understanding of KRAS biology. Further investigation of downstream effectors of LHX9 may highlight potentially novel therapeutic targets for KRAS-dependent cancers. Citation Format: Seav Huong Ly, Chao Dai, Andrew L. Hong, Nina Ilic, Elsa B. Krall, William C. Hahn. LHX9 is a novel oncogene bypassing KRAS addiction [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3515. doi:10.1158/1538-7445.AM2017-3515
Complementary and alternative treatments for migraine (2007)

Abstract A large percentage of patients do not respond to pharmacological interventions for migraine headaches, develop unacceptable side effects, or are reluctant to take medications. As a result, patients have been seeking nontraditional modes of therapy for the management of headaches. Among the alternative approaches are behavioral treatments (relaxation therapy, biofeedback therapy, and cognitive‐behavioral therapy), acupuncture, and nutritional therapies (herbal remedies and vitamin or mineral supplementation). This article reviews the scientific evidence for the use of magnesium, riboflavin, coenzyme Q 10 , α‐lipoic acid, feverfew, and butterbur in the treatment of migraine headaches. Drug Dev Res 68:424–427, 2007. © 2008 Wiley‐Liss, Inc.
Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes (2000)

Interactions between cell surface receptors are important regulatory elements in the complex host responses to infections. In this study, it is shown that a classic chemotactic factor, the bacterial chemotactic peptide N-formyl-methionyl-leucylphenyl-alanine (fMLF), rapidly induced a protein-kinase-C-mediated serine phosphorylation and down-regulation of the chemokine receptor CCR5, which serves as a major human immunodeficiency virus (HIV)-1 coreceptor. The fMLF binding to its receptor, formyl peptide receptor (FPR), resulted in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1-envelope-glycoprotein-mediated fusion and infection of cells expressing CD4, CCR5, and FPR. The finding that the expression and function of CCR5 can be regulated by peptides that use an unrelated receptor may provide a novel approach to the design of anti-inflamatory and antiretroviral agents. (Blood. 2000;96:2887-2894)
Thalidomide as treatment for digestive tract angiodysplasias. (2006)

An 80-year-old man with von Willebrand's disease was admitted with severe melaena. Despite suppletion with von Willebrand concentrate he continued to be dependent on blood transfusions. Endoscopic examination did not show a bleeding focus. Video capsule endoscopy showed active bleeding from angiodysplasias in the proximal section of the small intestine. Ultimately, treatment with thalidomide was initiated at a dose of 100 mg/day. Soon after starting treatment his stools became normal and his haemoglobin level stabilised. No bleeding problems occurred for 11 months, after which the thalidomide treatment was stopped because of the potential side effects. Two months later he again developed melaena and treatment with thalidomide was restarted with a successful outcome. Trying to lower the dose to 50 mg resulted in rebleeding after three months with stabilisation after increasing the dose to 100 mg again. Monotherapy with thalidomide improves the clinical picture but may not be sufficient in the long term. Additional therapy, such as argon plasma coagulation or the use of the novel drug lenalidomide, might be necessary.
Zwitterionic pyrrolidine-2,2-diylbis(phosphonic acid) at 100, 150 and 293 K (2000)

The title compound, C4H11NO6P2, reveals a two-dimensional network of P—O—H⋯O=P and N—H⋯O=P hydrogen-bond interactions, forming molecular slabs parallel with the (010) plane. One O—H⋯O interaction is distinct within these sets: whilst forming the shortest intermolecular hydrogen bond, it possesses a short P—O(H) bond of 1.5291 (10) Å. Weak C—H⋯O contacts link individual stacks to produce a three-dimensional array. The compound is zwitterionic: one H atom from a P—O—H group has transferred to the pyrrolidine ring N atom.
Cell-surface anchoring of Listeria adhesion protein on L. monocytogenes is fastened by internalin B for pathogenesis (2023)

Listeria adhesion protein (LAP) is a secreted acetaldehyde alcohol dehydrogenase (AdhE) that anchors to an unknown molecule on the Listeria monocytogenes (Lm) surface, which is critical for its intestinal epithelium crossing. In the present work, immunoprecipitation and mass spectrometry identify internalin B (InlB) as the primary ligand of LAP (K<sub>D</sub> ∼ 42 nM). InlB-deleted and naturally InlB-deficient Lm strains show reduced LAP-InlB interaction and LAP-mediated pathology in the murine intestine and brain invasion. InlB-overexpressing non-pathogenic Listeria innocua also displays LAP-InlB interplay. In silico predictions reveal that a pocket region in the C-terminal domain of tetrameric LAP is the binding site for InlB. LAP variants containing mutations in negatively charged (E<sub>523</sub>S, E<sub>621</sub>S) amino acids in the C terminus confirm altered binding conformations and weaker affinity for InlB. InlB transforms the housekeeping enzyme, AdhE (LAP), into a moonlighting pathogenic factor by fastening on the cell surface.
Small interfering RNAs targeting cyclin D1 and cyclin D2 enhance the cytotoxicity of chemotherapeutic agents in mantle cell lymphoma cell lines (2011)

Cyclin D1 (CCND1) is a known cell cycle regulator whose overexpression is a hallmark of mantle cell lymphoma (MCL). Although molecular techniques have unified the diagnostic approach to MCL, no therapeutic advances have been made to target this particular pathway. The significance of CCND1 in the pathogenesis and treatment of MCL has yet to be defined. We have taken advantage of RNA interference (RNAi) to down-regulate CCND1 expression in two MCL cell lines (Granta-519 and Jeko-1) to investigate the cytotoxic effect of combining RNAi with conventional chemotherapeutic agents. We designed four small interfering RNAs (siRNAs) specific to CCND1, one specific to CCND2, and one dual-targeting siRNA that simultaneously down-regulates CCND1 and CCND2. Etoposide and doxorubicin were used as chemotherapeutics in combination with the siRNAs. The transfected siRNAs in MCL cell lines triggered 40-60% reduction in target mRNA and protein levels. Importantly, the siRNA-mediated reduction in cyclins resulted in decreased IC(50) (50% inhibitory concentration) values for both doxorubicin and etoposide. The combination of siRNA-mediated inhibition of the cyclins along with chemotherapeutic agents could potentially be used to lower the effective doses of the chemotherapeutic agents and reduce drug-related toxicities.
Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over (2017)

Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n = 29) CD26 was increased on CD4<sup>+</sup> lymphocytes, CD39 and CD73 were generally reduced on patients' T-cells. In CD4<sup>+</sup> cells significant differences in CD73 expression were confined to memory CD45RA<sup>-</sup> cells, while in CD4<sup>-</sup> lymphocytes differences were significant in both naïve CD45RA<sup>+</sup> and memory CD45RA<sup>-</sup> cells. The percentage of CD4<sup>-</sup>CD73<sup>+</sup> cells correlated with micro-RNA (miR)-31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4<sup>-</sup>CD73<sup>+</sup> cells and serum CRP or eGFR require further functional elucidation.
Implementation of a Statewide Web-Based Caregiver Resource Information System (CareNav): Mixed Methods Study (Preprint) (2022)

<sec> <title>BACKGROUND</title> With the aging population, family caregivers provide increasingly complex and intense care for older adults and persons with disabilities. There is growing interest in developing community-based services to support family caregivers. Caregiving occurs around the clock, and caregivers face challenges in accessing community-based services at convenient times owing to the demands of care. Web-based resources hold promise for accessible real-time support. CareNav (TM), a caregiver resource information system, is a web-based platform designed to support real-time universal caregiver assessment, a record of client encounters, development of a care plan, tailored information and resource content, access to web-based caregiver resources, the capacity to track service authorization and contracts, and secure communications. The assessment includes needs and health conditions of both the care recipient and caregiver; current resources; and priorities for support, information, and referral. In 2019, the California Department of Health Care Services funded the 11 nonprofit California Caregiver Resource Centers (CRCs) to expand and improve family caregiver services and enhance CRC information technology services. Deployment of a statewide information system offered a unique opportunity to examine structures and processes facilitating implementation, providing feedback to the sites as well as lessons learned for similar projects in the future. </sec> <sec> <title>OBJECTIVE</title> The aim of this paper was to describe the statewide implementation of the comprehensive CareNav system using the Consolidated Framework for Implementation Research as an organizing structure for synthesizing the evaluation. </sec> <sec> <title>METHODS</title> This mixed methods study used two major approaches to evaluate the implementation process: a survey of all staff who completed training (n=82) and in-depth qualitative interviews with 11 CRC teams and 3 key informants (n=35). We initially analyzed interview transcripts using qualitative descriptive methods and then identified subthemes and relationships among ideas, mapping the findings to the Consolidated Framework for Implementation Research. </sec> <sec> <title>RESULTS</title> We present findings on the outer setting, inner setting, characteristics of the intervention, characteristics of the staff, and the implementation process. The critical elements for success were leadership, communication, harmonization of processes across sites, and motivation to serve clients in more accessible and convenient ways. </sec> <sec> <title>CONCLUSIONS</title> These findings have implications for technology deployment in diverse community-based agencies that aspire to enhance web-based services. </sec>
Miniaturized proteomics and peptidomics using capillary liquid separation and high resolution mass spectrometry (2004)

Knowledge of the protein and peptide content in a tissue or a body fluid is vital in many areas of medical and biomedical sciences. Information from proteomic and peptidomic studies may reveal alterations in expression due to, e.g., a disease and facilitate the understanding of the pathophysiology and the identification of biological markers. In this minireview, we discuss miniaturized proteomic and peptidomic approaches that have been applied in our laboratory in order to investigate the protein and peptide contents of body fluids (such as plasma, cerebrospinal and amniotic fluid), as well as extracted tissues. The methods involve miniaturized liquid separation, i.e., capillary liquid chromatography and capillary electrophoresis, combined with high resolution mass spectrometry (MS), i.e., Fourier transform ion cyclotron resonance MS. These approaches provide the opportunity to analyze samples of small volumes with high throughput, high sensitivity, good dynamic range and minimal sample handling. Also, the experiments are relatively easy to automate.