gebhart/patrepeval huggingface dataset:
Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation (2019)

Abstract Crossovers generated during the repair of programmed double-strand breaks (DSBs) during homologous recombination are essential for fertility to allow accurate homolog segregation during the first meiotic division. Most crossovers arise through the cleavage of recombination intermediates by the Mlh1-Mlh3 (MutLγ) endonuclease and an elusive non-catalytic function of Exo1, and require the Polo kinase Cdc5. Here we show in budding yeast that MutLγ forms a constitutive complex with Exo1, and in meiotic cells transiently contacts the Msh4-Msh5 (MutSγ) heterodimer, also required for crossover formation. We further show that MutLγ-Exo1 associates with recombination intermediates once they are committed to the crossover repair pathway, and then Exo1 recruits Cdc5 through a direct interaction that is required for activating MutLγ and crossover formation. Exo1 therefore serves as a non-catalytic matchmaker between Cdc5 and MutLγ. We finally show that in vivo , MutLγ associates with the vast majority of DSB hotspots, but at a lower frequency near centromeres, consistent with a strategy to reduce at-risk crossover events in these regions. Our data highlight the tight temporal and spatial control of the activity of a constitutive, potentially harmful, nuclease.
Modélisation numérique du laminage à pas de pèlerin de tubes ODS en vu de limiter les risques d'endommagement (2010)

Pour les Reacteurs a Neutrons Rapides au sodium, les materiaux de gainage de reference pour les tres forts taux de combustion sont les nuances ferritiques/martensitiques ODS. Ces materiaux presentent en effet des bonnes proprietes en fluage, en resilience et en resistance a l'oxydation. Toutefois la presence des oxydes ODS font de ces nuances des materiaux tres difficiles a mettre en forme. Classiquement le tube de gainage est mis en forme a froid a partir d'une ebauche tubulaire par une succession de passes de laminage a pas de pelerin et de traitements thermiques. Dans le cadre de cette etude la modelisation numerique du procede de laminage dans une configuration de type HPTR a ete entreprise. Le modele prend en compte toute la complexite des phenomenes physiques, mecaniques ainsi que le modele de comportement du materiau pour simuler les deformations elastoplastiques cycliques qui apparaissent au cours de la mise forme des tubes minces. La modelisation de la cinematique du procede a deja ete realisee. L'utilisation de capteurs numeriques pour suivre le chemin de deformation de la matiere lors du procede permet d'estimer la nature et l'amplitude des deformations cycliques subies.
Dynamic Shape and Appearance Models (2006)

We propose a model of the joint variation of shape and appearance of portions of an image sequence. The model is conditionally linear, and can be thought of as an extension of active appearance models to exploit the temporal correlation of adjacent image frames. Inference of the model parameters can be performed efficiently using established numerical optimization techniques borrowed from finite-element analysis and system identification techniques.
Characteristics associated with diabetic retinopathy in Nauruans. (1983)

A recent epidemiological survey of the whole adult Micronesian population of Nauru has confirmed that Nauruans, along with Pima Indians, suffer the highest rate of abnormal glucose tolerance yet recorded. To establish the morbid effects of hyperglycaemia in this population, all responders to the diabetes survey were concurrently examined for diabetic retinopathy. In diabetic subjects, the crude prevalence of retinopathy was 24%. Specific rates were determined at various levels of the following characteristics: age, 2 hour post-load plasma glucose, body mass index, duration of diabetes and systolic blood pressure. Prevalence was found to rise with increasing 2 hour plasma glucose and duration, to fall with increasing body mass index and to have a quadratic relationship with age and systolic blood pressure. The multiple logistic regression model was used to determine whether the selected characteristics were significant in increasing the risk of retinopathy. Body mass index and systolic blood pressure did not contribute significantly to this risk after controlling for age. Increasing 2 hour plasma glucose significantly increased the risk of retinopathy, and duration of disease was the strongest predictor variable. This study shows that the consequences of hyperglycaemia in this Micronesian population are comparable to those already documented in European and American Indian communities.
Mechanism for Persistent Luminescence in Sr2MgSi2O7:Eu2+, Dy3+ (2006)

Abstract not Available.
A tyre wear modelling approach for vehicle dynamics simulation and control-oriented analyses with application to motorcycles (2023)

To increase vehicle dynamics modelling accuracy in simulation environments, in this work, we propose a model, where the mutual influence of the vehicle dynamics and tyre wear is taken into account. In this context, simulation-oriented models aim at representing the main features of the vehicle dynamics, while keeping the complexity low, making them suitable for control-oriented analyses and design. The wear model quantifies tyre wear as a tyre mass loss depending on the tyre-road interaction, derived from the vehicle dynamics and kinematics; then, the outcome of this model is consequently used to update the tyre friction characteristics, by modifying the main parameters of the Pacejka's magic formula. We also discuss the steps required to use the model in two-wheeled vehicles, where the roll dynamics plays an important role in the tyre wear. The main features of the developed model are discussed on a motorcycle, as a simulation case-study.
Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period (2016)

This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high beta* are studied.
Utility maximization in peer-to-peer systems (2008)

In this paper, we study the problem of utility maximization in P2P systems, in which aggregate application-specific utilities are maximized by running distributed algorithms on P2P nodes, which are constrained by their uplink capacities. This may be understood as extending Kelly's seminal framework from single-path unicast over general topology to multi-path multicast over P2P topology, with network coding allowed. For certain classes of popular P2P topologies, we show that routing along a linear number of trees per source can achieve the largest rate region that can be possibly obtained by (multi-source) network coding. This simplification result allows us to develop a new multi-tree routing formulation for the problem. Despite of the negative results in literature on applying Primal-dual algorithms to maximize utility under multi-path settings, we have been able to develop a Primal-dual distributed algorithm to maximize the aggregate utility under the multi-path routing environments. Utilizing our proposed sufficient condition, we show global exponential convergence of the Primal-dual algorithm to the optimal solution under different P2P communication scenarios we study. The algorithm can be implemented by utilizing only end-to-end delay measurements between P2P nodes; hence, it can be readily deployed on today's Internet. To support this claim, we have implemented the Primal-dual algorithm for use in a peer-assisted multi-party conferencing system and evaluated its performance through actual experiments on a LAN testbed and the Internet.
One Thousand Vasectomies (1973)

In a prospective study of 1,000 people treated by vasectomy at the Margaret Pyke Centre under local anaesthesia as outpatients minor sepsis occurred in 12 cases, an abscess in one, and haematoma needing drainage in seven. Spontaneous recanalization of the vasa occurred in six patients and an unsuspected third vas was found in one.Except in patients with recanalization or a third vas the semen was always free from motile spermatozoa within three months, but non-motile spermatozoa have so far persisted for up to 17 months in a few cases.
Coherent Detection - Why is it back? (2007)

There is a renewed interest in coherent detection for robust high speed optical communication. We will examine the developments which have led to the current resurgence of research, review the latest research into digital coherent receivers and finally discuss the prospects for its commercial deployment.
Surface Effects on the Dynamics of Liquid Crystalline Thin Films Confined in Nanoscale Cavities (2000)

The dynamics of 4-n-pentyl-4‘-cyanobiphenyl (5CB) nematic liquid crystalline thin films have been studied in real time using step-scan Fourier transform infrared spectroscopy (FTIR). In these studies, the liquid crystal was confined in a nanocavity defined and bounded by an interdigitated gold electrode array. The gold microstructures were microfabricated on a zinc selenide (IR-transparent) window. The 5CB interactions with the ZnSe substrate result in surface-induced ordering of the ultrathin layers (on the order of 40 nm). As the films increase in thickness, the nanoscale organization induced by the surface layer becomes a less significant contributor to the overall bulk structure of the sample. Time-resolved FTIR studies have enabled the measurement of rate constants for the orientation and relaxation of the thin films under an applied electric field as a direct function of confinement dimensions. Cell thicknesses ranging from 40 to 300 nm were studied. The measured rate behaviors demonstrate the strong effects of the interactions occurring between the surfaces of the ZnSe crystals and the 5CB on the dynamics of the liquid crystalline assembly. Time-resolved studies reveal kinetically inhomogeneous line shapes for thicker films while ultrathin films maintain kinetically homogeneous peaks, suggesting the development of liquid crystalline domains or other inhomogeneities over this length scale in the transition from the surface layer to bulk.
Secondary Hyperparathyroidism Presenting with Vocal Cord Paralysis (2011)

ABSTRACT The association of vocal cord paralysis with tumors in the neck generally raises the suspicion of an underlying malignancy. We report the clinical course, imaging and operative findings in a patient with secondary hyperparathyroidism presenting with vocal cord paralysis. The related literature is also reviewed. A 45-year-old man with end-stage renal failure was awaiting surgical treatment for secondary hyperparathyroidism. Ultrasound of the neck demonstrated hypoechoic nodules consistent with enlarged parathyroid glands. Several months later, just before the scheduled date for parathyroid surgery, he developed increasing hoarseness and vocal fatigue. Direct laryngoscopy revealed an immobile left vocal cord (VC). Neck examination and further imaging did not reveal the source of VC palsy. A presumptive diagnosis of thyroid or parathyroid malignancy involving the recurrent laryngeal nerve (RLN) was made. Intraoperatively, four enlarged parathyroid glands were encountered. The left superior gland was seen stretching and displacing the RLN without evidence of direct invasion. This was successfully dissected off while preserving the RLN. The remaining three parathyroid glands were subsequently removed with autotransplantation of a parathyroid remnant. In addition, a left thyroid lobectomy and ipsilateral level VI dissection was performed. Final pathology revealed parathyroid hyperplasia and thyroid follicular adenoma. No malignancy was seen. Three weeks later, the patient's biochemistry had normalized and his voice improved. Laryngoscopy confirmed a mobile left VC. Benign parathyroid tumors are rarely associated with RLN compression leading to VC paralysis. Such diagnoses are difficult to make preoperatively. In the absence of malignant invasion, the RLN should be preserved during surgery as it is likely to recover once the compression is relieved.
Electroluminescence: (Highly Emitting Neutral Dinuclear Rhenium Complexes as Phosphorescent Dopants for Electroluminescent Devices) Adv. Funct. Mater. 16/2009 (2009)

Neutral, dinuclear, highly luminescent rhenium(I) complexes are prepared and their photophysical and electrochemical properties investigated by Professor Luisa De Cola and co-workers. For the first time, electroluminescent devices, using a rhenium complex as dopant, obtained by sublimation and by solution processing are described.
Increased Vascular permeability produced by human platelet granule cationic extract (1970)

A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.
The ODAC chronicles: Part 1. My first ODAC experience (2004)

(2004). The ODAC chronicles: Part 1. My first ODAC experience. Expert Review of Anticancer Therapy: Vol. 4, No. 5, pp. 709-712.
Nuclear magnetic resonance imaging of the infarcted muscle: a rat model. (1983)

Eleven Sprague-Dawley rats with experimentally produced infarction of the lower extremities were imaged by nuclear magnetic resonance (NMR) immediately after infarction, and 6 and 24 hours later. Contrast between the infarcted and control muscles was noted immediately and continued to increase through 24 hours. These changes corresponded to a significant increase in the water content of the infarcted extremity at 24 hours. These results suggest promise for NMR imaging in the identification of myocardial infarction and should encourage further investigation in this area.
Ecological or Recalled Assessments in Chronic Musculoskeletal Pain? A Comparative Study of Prospective and Recalled Pain Assessments in Low Back Pain and Lower Limb Painful Osteoarthritis (2011)

For both low back pain and osteoarthritis, overall daily pain recall is a reliable measurement correlated with daily ecological measurements, whereas a rapid decrease in recall occurs after 48 hours. The most reliable period for pain recall was 7 days, but the results obtained were influenced by current pain.
Structural Effects on Swelling of Thin Phosphorylcholine Polymer Films (2002)

Spectroscopic ellipsometry (SE) has been used to monitor the time-dependent process of swelling of phosphorylcholine (PC) biocompatible polymer films of different initial dry film thicknesses. Factors including the extent of silyl cross-linker, ratio of hydrophilic and hydrophobic moieties, annealing temperature, and the composition of a set of polymer blends were assessed. The swelling of PC polymer films was found to follow a two-stage mechanism: a fast film expansion at the beginning of film immersion, followed by a much slow process controlled by the relaxation of polymer fragments. The two-stage swelling was well described by the coupled model developed by Berens and Hopfenberg, which assumed a simple superposition between the fast Fickian diffusion and the exponential decay accounting for the slow polymer fragment relaxation. Increase in annealing temperature to films incorporating 5 mol % silyl cross-linkers reduced the rate of swelling, which was attributed to the combined action of structure ordering and the strengthening of silyl cross-linking network. Increase in hydrophilic moieties substantially promoted the rate of swelling and their equilibrated water uptake, as expected. In the case of the blends from the two polymers with and without 5% silyl cross-linker, the swelling behavior was dominated by the cross-linked polymer.
Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders (2004)

Memory B cells are responsible for the rapidly emerging antibody response after antigen reexposure. The signals required for the restimulation of memory B cells have not been fully explained. We used a murine model of anti-factor VIII (FVIII) antibody responses in hemophilia A to study the requirements for the restimulation of FVIII-specific memory B cells and their differentiation into anti-FVIII antibody-producing cells. We were particularly interested in the significance of activated T cells and costimulatory interactions. Our results indicate that the restimulation of FVIII-specific memory B cells is strictly dependent on interactions with activated T cells. These activated T cells can be specific for either FVIII or third-party antigens. Restimulation by T cells specific for third-party antigens requires the presence of FVIII, indicating that signals induced by B-cell receptor (BCR) triggering and by interactions with activated T cells are important. The blockade of B7-1 or B7-2 as well as the blockade of CD40L inhibits the restimulation and differentiation of FVIII-specific memory B cells in vitro and in vivo. The interference with inducible costimulator-inducible costimulator ligand (ICOS-ICOSL) interactions, however, does not cause any modulation. As expected, the production of anti-FVIII antibodies by plasma cells is not dependent on any of the costimulatory interactions tested.
CORRECTION OF MODERATE AND SEVERE ACQUIRED FLEXIBLE FLATFOOT WITH MEDIALIZING CALCANEAL OSTEOTOMY AND FLEXOR DIGITORUM LONGUS TRANSFER (2006)

Background: Acquired flexible flatfoot encompasses a wide spectrum of disease, and there is no validated treatment protocol. We hypothesized that a medializing calcaneal osteotomy with a flexor digitorum longus transfer is adequate to correct a less severe acquired flexible flatfoot but not a more severe flatfoot. We also hypothesized that use of an additional procedure would further correct the flatfoot. Methods: The study included seven pairs of cadaver specimens, with one side randomly selected for the creation of a mild flatfoot deformity and the other, for the creation of a severe flatfoot deformity. Cyclic axial load was applied to the intact foot, to the flatfoot, after correction with a medializing calcaneal osteotomy and a flexor digitorum longus transfer, and after the addition of a subtalar arthroereisis. Radiographic and pedobarographic data were obtained at each stage. A repeated-measures analysis of variance with post hoc analysis was used to compare all parameters in the intact foot with those in the flatfoot and corrected specimens. A Student t test was used to compare flatfoot severity between the mild and severe models. Results: Compared with the intact foot, the mild and severe flatfoot models showed a significant change in the talar-first metatarsal angle (p = 0.01 and 0.03, respectively), talonavicular angle (p = 0.04 and 0.04), and medial cuneiform height (p = 0.03 and 0.05). The mild and severe models were significantly different from each other with regard to the talar-first metatarsal angle (p = 0.003) and talonavicular angle (p = 0.002). After the osteotomy and tendon transfer in the mild-flatfoot model, the talar-first metatarsal angle and talonavicular angle were not significantly different from those in the intact state. In the severe-flatfoot model, the talar-first metatarsal angle, talonavicular angle, and medial cuneiform height remained significantly undercorrected after the osteotomy and tendon transfer. After the arthroereisis, the talonavicular angle and medial cuneiform height were not significantly different from the values for the intact foot. Conclusions: In a cadaver model, the effectiveness of different procedures on radiographic and pedobarographic parameters varies with the severity of an acquired flatfoot deformity. Clinical Relevance: This study suggests that less severe acquired flexible flatfoot might be appropriately treated with a combined medializing calcaneal osteotomy and flexor digitorum longus transfer and that severe flatfoot might require an additional procedure for adequate correction.
ChemInform Abstract: A New Class of Potent RAR Antagonists: Dihydroanthracenyl, Benzochromenyl, and Benzothiochromenyl Retinoids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T epidisphaerales (2019)

Abstract Te.pi.di.sphae.ra'les. N.L. fem. n. Tepidisphaera , type genus of the order; ‐ales ending to denote an order; N.L. fem. pl. n. Tepidisphaerales , the order of genus Tepidisphaera . The order Tepidisphaerales is circumscribed on the basis of 16S rRNA gene phylogenetic analysis. The order currently contains only a single family, Tepidisphaeraceae . Cells are Gram‐negative cocci. Divide by binary fission. Grow organoheterotrophically on simple or complex carbohydrates. Aerobes, facultative anaerobes. Type genus : Tepidisphaera Kovaleva, Merkel, Novikov, Baslerov, Toshchakov and Bonch‐Osmolovskaya 2015, 553 VP . Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the order Tepidisphaerales is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Pseudomonadati / Planctomycetota / Phycisphaerae / Tepidisphaerales Tepidisphaerales could not be recovered in GTDB ** . * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
ChemInform Abstract: Highly Enantio‐ and Diastereoselective Hetero‐Diels—Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.