PD39-12 THE CO-OCCURRING SYNDROME - OVERLAP OF ED AND BPH AND THEIR CLINICAL CORRELATES IN AGING MEN: RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY. (2015)

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History1 Apr 2015PD39-12 THE CO-OCCURRING SYNDROME - OVERLAP OF ED AND BPH AND THEIR CLINICAL CORRELATES IN AGING MEN: RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY. Arthur L. Burnett, Kathryn Egan, Minhyung Suh, Kevin T. McVary, Claus Roehrborn, David Wong, Xiao Ni, and Raymond Rosen Arthur L. BurnettArthur L. Burnett More articles by this author , Kathryn EganKathryn Egan More articles by this author , Minhyung SuhMinhyung Suh More articles by this author , Kevin T. McVaryKevin T. McVary More articles by this author , Claus RoehrbornClaus Roehrborn More articles by this author , David WongDavid Wong More articles by this author , Xiao NiXiao Ni More articles by this author , and Raymond RosenRaymond Rosen More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2407AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) are highly prevalent, age-related conditions in men, with frequent co-occurrence of the two disorders worldwide. Despite this, little is known about specific factors associated with co-occurring ED/BPH and the potential increased health risks associated with co-occurrence. Using a nationally representative population of U.S. men, we established a descriptive profile of men with co-existent ED/BPH, ED only, or BPH only compared to men with neither, and, 2) we identified specific determinants of co-occurring ED/BPH in multivariable regression analyses and association differences by disease status. METHODS Complete data on prostate conditions and erectile function were collected in men age ≥40 years (N=2,142) from the 2001-2004 National Health and Nutrition Examination Surveys (NHANES) and standardized medical examinations. Analyses were weighted to account for survey design, nonresponse bias, and the probability of selection into the sample. ED and BPH were defined by self-report and/or medication use. Descriptive analyses examined the distribution of covariates by ED/BPH. Odds ratios (OR) with 95% confidence intervals were calculated using multinomial logistic regression. RESULTS Of 393 men with BPH, 57.8% had co-existent ED, confirming the moderately strong conditional probability between the conditions (p<0.0001). The overall prevalence in men aged ≥40 years of co-occurring ED/BPH was 10.6%, while 24.4% and 7.7% of men reported ED only and BPH only. After age 60, the odds of reporting ED only, BPH only, or ED/BPH almost tripled for each decade of increasing age, corresponding to an increase in the prevalence of each condition. The unadjusted odds of ED/BPH increased 1.3 times per unit increase in PSA (ng/mL) and 1.1 times per unit increase in C-reactive protein (mg/L). In addition to age, other predisposing factors for ED/BPH included higher BMI or presence of obesity (OR=2.5), increased use of prescription medications (antidiabetics (OR=2.9), proton pump inhibitors (OR=2.3)), increased number healthcare visits (OR=3.5), and more frequent urinary symptoms (voiding difficulty (OR=9.7)). CONCLUSIONS We identified a substantial overlap between ED and BPH in the NHANES surveys and related clinical correlates, such as obesity. Our findings support the need for clinicians to actively investigate the presence of either condition in at risk men. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e834-e835 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Arthur L. Burnett More articles by this author Kathryn Egan More articles by this author Minhyung Suh More articles by this author Kevin T. McVary More articles by this author Claus Roehrborn More articles by this author David Wong More articles by this author Xiao Ni More articles by this author Raymond Rosen More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...