gebhart/patrepeval huggingface dataset:
A Novel Continuum Robot Using Twin-Pivot Compliant Joints: Design, Modeling, and Validation (2015)

A twisting problem is identified from the central located flexible backbone continuum robot. Regarding this problem, a design solution is required to mechanically minimize this twisting angle along the backbone. Further, the error caused by the kinematic assumption of previous works is identified as well, which requires a kinematic solution to minimize. The scope of this paper is to introduce, describe and teste a novel design of continuum robot which has a twin-pivot compliant joint construction that minimizes the twisting around its axis. A kinematics model is introduced which can be applied to a wide range of twin-pivot construction with two pairs of cables per section design. And according to this model, the approach for minimising the kinematic error is developed. Furthermore, based on the geometry and material property of compliant joint, the work volumes for single/three-section continuum robot are presented, respectively. The kinematic analysis has been verified by a three-section prototype of continuum robot and adequate accuracy and repeatability tests carried out. And in the test, the system generates relatively small twisting angles when a range of end loads is applied at the end of the arm. Utilising the concept presented in this paper, it is possible to develop a continuum robot which can minimize the twisting angle and be accurately controlled. In this paper, a novel design of continuum robot which has a twin-pivot compliant joint construction that minimizes the twisting around its axis is introduced, described and tested. A kinematics model is introduced which can be applied to a wide range of twin-pivot construction with two pairs of cables per section design. Furthermore, based on the geometry and material property of compliant joint, the work volumes for single/three-section continuum robot are presented, respectively. Finally, the kinematic analysis has been verified by a three-section prototype of continuum and adequate accuracy and repeatability tests carried out.
Smoking confounds the periodontal diagnostics using saliva biomarkers (2018)

Smoking confounds the salivary diagnostics of periodontitis and should be considered when interpreting the results obtained by potential diagnostic tests.
Efficacy of Hepatitis B Immune Globulin for Prevention of De Novo Hepatitis B in Living-related Liver Transplantation (2003)

Purpose: Hepatic allografts from donors with hepatitis B core antibody have been demonstrated to transmit hepatitis B virus (HBV) infection to recipients after liver transplantation (LT).The efficacy of hepatitis B immune globulin (HBIg) to prevent de novo hepatitis B was investigated by comparing active immunization in the early phase to HBIg monotherapy in the late phase of pediatric liver transplants at Samsung Medical Center.Methods: Among pediatric liver transplants, from May, 1996 to June, 2002, 15 recipients who were hepatitis B surface antigen (HBsAg) (-) received an allograft from a donor with hepatitis B core antibody (HBcAb) (+).Except two who died from unrelated causes, eleven of 13 recipients were HBsAb (+), and 2 were naive (HBsAb(-), HBcAb(-)).All patients were vaccinated for HBV before LT.In the early phase (January, 1997November, 1997, 3 patients), HBsAb (+) recipients received booster vaccination after LT.In the late phase (December, 1997, 10 patients), all recipients were given booster vaccination and received HBIg therapy in order to maintain HBsAb titer greater than 200 IU/L.Lamivudine was given in one case because of severe side effect of HBIg.We retrospectively analyzed the effect of the preventive therapy for de novo hepatitis B through medical records.Results: De novo hepatitis B developed in three of 13 recipients (23.1%).All of 3 patients who received active immunization in the early phase became HBsAg (+) at 719 months after
ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles (2015)

The ISOpureR package estimates the fraction of cancer cells and personalized patient cancer mRNA abundance profile from a mixed tumour profile. This open-source R implementation enables integration into existing computational pipelines, as well as easy testing, modification and extension of the model.
Electrohydrodynamic Jet Printing of One‐Dimensional Photonic Crystals: Part I—An Empirical Model for Multi‐Material Multi‐Layer Fabrication (2020)

Abstract Electrohydrodynamic jet (e‐jet) printing is a high‐resolution additive manufacturing technique that holds promise for the fabrication of customized micro‐devices. In this companion paper set, e‐jet printing is investigated for its capability in depositing multilayer thin‐films with microscale spatial resolution and nanoscale thickness resolution to create arrays of 1D photonic crystals (1DPC). In this paper, an empirical model for the deposition process is developed, relating process and material parameters to the thickness and uniformity of the patterns. Standard macroscale measurements of solid surface energy and liquid surface tension are used in conjunction with microscale contact angle measurements to understand the length scale dependence of material properties and their impact on droplet merger into uniform microscale thin‐films. The model is validated with several photopolymer inks, a subset of which is used to create pixelated, multilayer arrays of 1DPCs with uniformity and resolution approaching standards in the optics manufacturing industry. It is found that the printed film topography at the microscale can be predicted based on the surface energetics at the microscale. Due to the flexibility in design provided by the e‐jet process, these findings can be generalized for fabricating additional multimaterial, multilayer micro‐ and nanostructures with applications beyond the field of optics.
Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care (2019)

Being responsible for delayed wound healing, the presence of biofilms in infected wounds leads to chronic, and difficult to treat infections. One of the reasons why antimicrobial treatment often fails to cure biofilm infections is the reduced penetration rate of antibiotics through dense biofilms. Strategies that have the ability to somehow interfere with the integrity of biofilms and allowing a better penetration of drugs are highly sought after. A promising new approach is the use of laser-induced vapor nanobubbles (VNB), of which it was recently demonstrated that it can substantially enhance the penetration of antibiotics into biofilms, resulting in a marked improvement of the killing efficiency. In this study, we examined if treatment of biofilms with laser-induced vapor nanobubbles (VNB) can enhance the potency of antimicrobials which are commonly used to treat wound infections, including povidone-iodine, chlorhexidine, benzalkonium chloride, cetrimonium bromide and mupirocin. Our investigations were performed on <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> biofilms, which are often implicated in chronic wound infections. Pre-treatment of biofilms with laser-induced VNB did enhance the killing efficiency of those antimicrobials which experience a diffusion barrier in the biofilms, while this was not the case for those compounds for which there is no diffusion barrier. The magnitude of the enhanced potency was in most cases similar to the enhancement that was obtained when the biofilms were completely disrupted by vortexing and sonication. These results show that laser-induced VNB are indeed a very efficient way to enhance drug penetration deep into biofilms, and pave the way towards clinical translation of this novel approach for treatment of wound infections.
Supplementary Figure 1 from Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein (2023)

&lt;p&gt;- PDF file 79K, GAG-HERV-K ch22q11.23 features. Endogenous retrovirus K from chromosome 22 is located on the q11.23 region, nearby the BCR, ZDHHC8P, IGLL1 and RGL4 genes. HERV-K ch22q11.23 has GAG-PRO, POL and ENV genes flanked by LTR sequences. The GAG gene has an ORF encoding a 715aa protein that contains P10, P24 and Zinc finger domains. {delta}: deletions; I: early stop codons; --&gt; primer binding regions; ABS: antibody binding site for monoclonal antibody TI-35 (see Supplementary Fig. S3C)&lt;/p&gt;
Individual Preference Probability Modeling for Video Content in Wireless Caching Networks (2017)

Caching of video files at the wireless edge, i.e., at the base stations or on user devices, is a key method for improving wireless video delivery. While global popularity distributions of video content have been investigated in the past, and used in a variety of caching algorithms, this paper investigates the statistical modeling of the individual user preferences. With individual preferences being represented by probabilities, we identify their critical features and parameters and propose a novel modeling framework as well as a parameterization of the framework based on an extensive real-world data set. Besides, an implementation recipe for generating practical individual preference probabilities is proposed. By comparing with the underlying real data, we show that the proposed models and generation approach can effectively characterize individual preferences of users for video content.
Low Temperature Elastic, Electronic and Transport Properties of Ti3SixGe1-xC2 Solid Soutions (2004)

This thesis presents a theoretical study of bulk materials using ab initio methods based on the density functional theory (DFT).Crystallographic structural phase transformations and phase stability for 5f-dioxides, ABO3 perovskites, and ABO4 compounds have been extensively studied. Different approaches such as static total energy calculations, elastic stability and dynamical stability (phonon calculations) criteria have been used to determine the phase stability. As a special case, the lattice dynamics of solid Xe has been studied as a function of pressure.Dielectric functions and optical constants have been calculated for solar energy cell system CuIn1-xGaxSe2 with concentrations x=0, 0.25, 0.5 and 1.0 as well as for C60, PbWO4 and δ-AlOOH. The absorption coefficient provides information about the optimum solar energy conversion efficiency. We have derived absorption coefficients for a number of compounds. Comparisons between the calculated and experimental dielectric functions and absorption coefficients have been made.The main part of this thesis focuses on the nanolayered ternary compounds M N+1AXN (MAX), where N = 1, 2 or 3, M is an early transition metal, A is an A-group (mostly IIIA and IVA) element, and X is either C and/or N. These ternary carbides and nitrides combine unusual properties of both metals and ceramics. They exhibit high hardness, but fully reversible plasticity, and negligible thermoelectric power. These excellent properties make the MAX phases another new class of materials with versatile technological applications. Our work presents a systematic study of the electronic, bonding, elastic and optical properties of the MAX phases. A new MAX phase-Ti4SiC3, is calculated to be stable, and at the same time also been synthesized by experimentalists. Surface energy calculations have also been performed for the (0001) surface of the Ti-Si-C system. The general relations between the electronic structure and materials properties of the MAX phases have been elaborated in the thesis.
The Role of Syntaxins in the Specificity of Vesicle Targeting in Polarized Epithelial Cells (2005)

In polarized epithelial cells syntaxin 3 is at the apical plasma membrane and is involved in delivery of proteins from the trans-Golgi network to the apical surface. The highly related syntaxin 4 is at the basolateral surface. The complementary distribution of these syntaxins suggests that they play a role in the specificity of membrane traffic to the two surfaces. We constructed a chimeric syntaxin where we removed the N-terminal 29 residues of syntaxin 3 and replaced it with the corresponding portion of syntaxin 4. When expressed in polarized epithelial cells, this chimera was exclusively localized to the basolateral surface. This indicates that the N-terminal domain of syntaxin 3 contains information for its polarized localization. In contrast to the apical localization of syntaxin 3, the basolateral localization of syntaxin 4 was not dependent on its N-terminal domain. Syntaxin 3 normally binds to Munc18b, but not to the related Munc18c. Overexpression of the chimera together with overexpression of Munc18b caused membrane and secretory proteins that are normally sent primarily to the apical surface to exhibit increased delivery to the basolateral surface. We suggest that syntaxins may play a role in determining the specificity of membrane targeting by permitting fusion with only certain target membranes.
Supplementary Figure Legend from Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity (2023)

&lt;p&gt;Figure Legend to all supplementary data&lt;/p&gt;
T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the hLa class II haplotype DRB1*0301/DQB1*0201 (2007)

Multiple DR3-restricted epitopes of hLa have been identified. These findings suggest that truncation of La produced by somatic mutation or possibly granzyme B-mediated cleavage alters the immunodominance hierarchy of T cell responsiveness to hLa and may be a factor in the initiation or maintenance of anti-La autoimmunity.
Infrared Supercontinuum Fiber Sources (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Shaw, R. R. Gattass, J. Sanghera, and I. Aggarwal, "Infrared Supercontinuum Fiber Sources," in Advanced Photonics, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper SOTuA4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Location-based Data Model for Optimized Network Slice Placement (2020)

Network Slicing has its roots in Network Function Virtualization (NFV) allowing high flexibility in the delivery of end-to-end network services. To achieve Network Slicing promises on efficiency, Network Slice Providers have to ensure optimized resource utilization and to guarantee Quality of Service when managing the life-cycle of a Network Slice. We focus in this paper on Network Slice Placement, intimately related to the VNF Placement and Chaining problem. In contrary to most studies related to VNF placement, we deal with the most complete and complex Network Slice topologies and we pay special attention to the geographic location of Network Slice Users. We propose a data model adapted to Integer Linear Programming. Extensive numerical experiments assess the relevance of taking into account the user location constraints.
Methods for the characterization of deformable membrane mirrors (2005)

We demonstrate two methods for the characterization of deformable membrane mirrors and the training of adaptive optics systems that employ these mirrors. Neither method employs a wave-front sensor. In one case, aberrations produced by a wave-front generator are corrected by the deformable mirror by use of a rapidly converging iterative algorithm based on orthogonal deformation modes of the mirror. In the other case, a simple interferometer is used with fringe analysis and phase-unwrapping algorithms. We discuss how the choice of singular values can be used to control the pseudoinversion of the control matrix.
Second-Generation Mimics of Ganglioside GM1 Oligosaccharide: A Three-Dimensional View of Their Interactions with Bacterial Enterotoxins by NMR and Computational Methods (2002)

As a step to delineate a strategy of ligand design for cholera toxin (CT), NMR studies were performed on several mimics of the GM1 ganglioside oligosaccharide. The conformation of these analogues was investigated first in solution and then upon binding to cholera toxin by transferred nuclear Overhauser effect (TR-NOE) measurements. It was demonstrated that CT selects a conformation similar to the global minima of the free saccharides from the ensemble of presented conformations. No evidence of major conformational distortions was obtained, but one or two of the available conformers of the hydroxyacid side chain appear to be selected in the bound state. The NMR data were interpreted with the aid of computer models, generated and analyzed by using a combination of different approaches (MacroModels' MC/EM and MC/SD, Autodock, and GRID). Analysis of the NMR data supported by computational studies allowed us to interpret the experimental observations and to derive workable models of the ligand:toxin complexes. These models suggest that the higher affinity of the (R)-lactic acid derivative 3 may stem from lipophilic interactions with a hydrophobic area in the toxin binding site located in the vicinity of the sialic acid side chain binding region of the CT:GM1 complex, and formed by the side chain of Ile-58 and Lys-34. Thus, the models obtained have allowed us to make useful design suggestions for the improvement of ligand affinity.
Performance of MRI-TRUS-guided fusion biopsy to detect progression on active surveillance for low- and intermediate-risk prostate cancer. (2015)

43 Background: Active surveillance (AS) is an established treatment option for men with low risk prostate cancer. Its role in intermediate prostate cancer is still being investigated. Recent studies have shown that multiparametric-MRI (mp-MRI) along with MRI-TRUS fusion-guided biopsy may better assess risk in patients eligible for AS, compared to 12-core biopsy, due to improved detection of clinically significant cancers. The objective is to determine the performance of MRI-TRUS guided biopsy for men on AS with both low and intermediate risk disease. Methods: Between 2007-2014 men on AS were included if they had complete mp-MRI and pathology data for 2 or more MRI-TRUS biopsy sessions. Fusion guided biopsy procedures consisted of MRI identified targeted biopsies as well as random 12 core biopsies. Men were allowed to participate in AS with low and intermediate risk prostate cancer, Gleason score ≤ 3+4=7. Progression was defined by patients with initial Gleason 3+3=6 to any Gleason 4, and Gleason 3+4=7 disease progressing to a primary Gleason 4 or higher. Results: 89 men met our study criteria with an average age of 62 years old (range 45-79). 75 men had low risk Gleason 3+3=6 at the outset of AS by 1st biopsy session with a median PSA 5.1 ng/ml. The other 14 men had intermediate risk prostate cancer Gleason 3+4=7 at the outset of AS and a median PSA 4.6 ng/ml. During follow-up, 25 (33%) low risk men progressed to 3+4 or above at a median of 20.6 months. Of these, 19 were found by targeted biopsy. 6 (43%) of the intermediate risk men progressed to Gleason 4+3=7 at a median of 36.8 months. 4 of these progressed on targeted fusion biopsy. In the intermediate risk men, 84 random biopsy cores were require to detect 1 progression versus 15 targeted biopsy cores to detect 1 progression. Conclusions: The majority of patients on AS who progressed were identified by MRI-TRUS targeted biopsy. Less biopsy cores are required to detect progression with targeted biopsy. These results are preliminary and a larger cohort with longer follow-up would be beneficial.
Effects of Basic Cosmetics Purchase Behavior on Customized Cosmetics Purchase Intention: Focusing on the Meditating Role of Self-efficacy (2022)

개인의 특성과 취향을 존중하고 반영하는 커스터마이징(Customizing) 산업에 맞추어 맞춤형화장품이 합법화 되었다. 개인의 피부와 취향에 맞는 소비자 중심의 화장품 조제가 가능한 것이다. 기초화장품의 선택기준은 개인의 피부타입(Type), 효능·효과의 정도, 연령, 가격, 브랜드(Brand), 품질, 주변권유 및 사용 후기 등이며 기초화장품 이용 시에는 주변의 권유를 받거나, 사용 중 불편사항에 대한 화장품제조 및 책임판매회사에 문의하거나 식품의약품안전처 홈페이지(Homepage)를 통한 정보를 이용하며 견본품(Sample)을 사용해보고, 제조사의 임상자료를 확인하기도 한다. 자기효능감의 정도는 화장품 사용에 있어서 관련 성분이나 기능을 설명하고 용어를 이해하며 관련 정보수집의 능숙함의 정도이다. 선행조사들에서 맞춤형화장품에 가장 적합한 제품이 기초화장품으로 조사된 것을 바탕으로 맞춤형화장품 구매의도에 미치는 기초화장품 영향 정도를 파악하기 위하여 기초화장품 구매행태를 구매형태(선택기준)와 이용실태(이용기준)의 하위요인으로 나누고 자기효능감의 매개효과를 검증하였다. 본 연구를 위해 수집된 자료(Data)는 2021년 9월 13일부터 10월 19일까지 모바일을 통해 부산, 경남, 경북 소재 6개 대학의 대학생을 대상으로 설문 조사하여 총 200부를 배포하여 유효 응답 193부를 분석 연구하였고 분석 방법은 실증분석 SPSS 25.0 프로그램을 이용하여 신뢰도, 타당성, 회귀분석을 실시하였다. 연구 결과, 기초화장품 구매행태 중 하위요인인 선택기준 즉, 구매형태가 자기효능감, 맞춤형화장품 구매의도에 모두 작용하고 자기효능감도 기초화장품 구매형태와 맞춤형화장품 구매의도와의 관계에서만 매개효과로 작용하였다. 본 연구가 맞춤형화장품 품목의 선정, 판매확대를 위한 전략 개발, 사용자 범위의 확대 등 맞춤형화장품 산업 활성화의 실질적인 기초자료로 활용되기를 기대한다.
Automated Driving in Complex Real-World Scenarios using a Scalable Risk-Based Behavior Generation Framework (2021)

The task of driving autonomously is difficult due to the vast number of driving situations a system may be facing. Especially higher levels of automation in less restricted scopes remain a topic of active research. In previous work, we introduced a behavior planning system which uses analytic models to evaluate the quality of behavior holistically. It uses these models to generate quality-maximizing behavior instead of selecting among predefined behavior primitives. The system was able to solve various complex urban traffic scenarios in large-scale simulations. In this paper, we verify the system using multiple prototype vehicles on proving grounds in a number of difficult urban scenarios such as prioritized intersections or overtaking. We describe the system architecture and principles which render the system embodiment-agnostic and make extensions for additional features possible without massively increasing the complexity.
ChemInform Abstract: ADDITION VON ATOMEN DER GRUPPE VIA AN TETRAMETHYLAETHYLEN, EINE ADDITIONSRK. MIT NEGATIVER AKTIVIERUNGSENERGIE (1971)

Abstract Die Kinetik der Addition von Te( 3 P 2 )‐Atomen (erzeugt durch Blitzlichtphotolyse von Dimethyltellurid in CO 2 ) an die Olefine (Ia), (Ib) und (IIa) und die der Addition von S( 3 P)‐Atomen (Blitzlicht‐Photolyse von COS/CO 2 ) an (Ia) bis (Ic), (IIa) bzw. (IIb) wird gemessen.
Effect of Synthetic Ovine Corticotropin-Releasing Factor: Prolonged Duration of Action and Biphasic Response of Plasma Adrenocorticotropin and Cortisol* (1983)

The duration of the response to synthetic ovine corticotropin-releasing factor (CRF) was studied in 13 healthy male volunteer subjects. Placebo or CRF (0.3, 3, or 30 micrograms/kg BW) was administered as an iv bolus or, in the case of the largest dose, a 30-sec infusion in single blind fashion in the late afternoon. Basal plasma immunoreactive ACTH (IR-ACTH) and IR-cortisol were 10.8 +/- 7.7 pg/ml and 5.0 +/- 1.8 micrograms/dl (mean +/- SD), respectively. IR-ACTH rose rapidly after CRF, reached an initial peak at 15 min, fell rapidly until 1.5 h after CRF, and then either fell more slowly (after the lowest dose) or rose to a second major peak at 2-3 h before falling back to baseline. After 0.3, 3, and 30 micrograms/kg CRF, IR-ACTH remained elevated for 4, 7, and 8 h, respectively. The effect on plasma IR-cortisol was similar, but more prolonged. The magnitude of both peaks of IR-ACTH, the duration of the response, and the area under the curve all appeared dose dependent. The same was true for IR-cortisol, except that the first peak height was similar after all three doses. The duration of CRF's action is probably due to its long circulating half-life. The biphasic response curve may reflect initial secretion of a readily releasable pool of ACTH, followed by later secretion of a second pool of newly synthesized and/or matured peptide. The next morning's normal circadian rise in both IR-ACTH and IR-cortisol was delayed and diminished after 3 micrograms/kg CRF; there was no increase in IR-ACTH after 30 micrograms/kg CRF, and the IR-cortisol level was diminished. Inhibition of the normal circadian rise may reflect inhibition of ACTH secretion by the sustained high plasma cortisol levels.