gebhart/patrepeval huggingface dataset:
Single-Molecule Magnets:  A New Approach To Investigate the Electronic Structure of Mn12 Molecules by Scanning Tunneling Spectroscopy (2007)

A new approach to the deposition of Mn12 single-molecule magnet monolayers on the functionalized Au(111) surface optimized for the investigation by means of scanning tunneling spectroscopy was developed. To demonstrate this method, the new Mn12 complex [Mn12O12(O2CC6H4F)16(EtOH)4].4.4CHCl3 was synthesized and characterized. In MALDI-TOF mass spectra the isotopic distribution of the molecular ion peak of the latter complex was revealed. The complex was grafted to Au(111) surfaces via two different short conducting linker molecules. The Mn12 molecules deposited on the functionalized surface were characterized by means of scanning tunneling microscopy showing homogeneous monolayers of highest quality. Scanning tunneling spectroscopy measurements over a wider energy range compared with previous results could be performed because of the optimized Au(111) surface functionalization. Furthermore, the results substantiate the general suitability of short acidic linker molecules for the preparation of Mn12 monolayers via ligand exchange and represent a crucial step toward addressing the magnetic properties of individual Mn12 single-molecule magnets.
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience (2021)

The coronavirus disease 2019 (COVID-19) pandemic has revealed that even the best-resourced hospitals may lack sufficient ventilators to support patients under surge conditions. During a pandemic or mass trauma, an affordable, low-maintenance, off-the-shelf device that would allow health care teams to rapidly expand their ventilator capacity could prove lifesaving, but only if it can be safely integrated into a complex and rapidly changing clinical environment. Here, we define an approach to safe ventilator sharing that prioritizes predictable and independent care of patients sharing a ventilator. Subsequently, we detail the design and testing of a ventilator-splitting circuit that follows this approach and describe our clinical experience with this circuit during the COVID-19 pandemic. This circuit was able to provide individualized and titratable ventilatory support with individualized positive end-expiratory pressure (PEEP) to 2 critically ill patients at the same time, while insulating each patient from changes in the other's condition. We share insights from our experience using this technology in the intensive care unit and outline recommendations for future clinical applications.
Preliminary measurement results from an adaptive antenna array testbed for GSM/UMTS (2002)

This paper presents preliminary measurement results for an 8 element adaptive antenna array in an urban environment. The results show that in most cases the received signal consists of a single narrowly scattered component impinging from the direction towards the mobile. The angular spread (AS) is found to be no larger than 5 degrees for the test measurements. The correlation coefficient between slow fading and AS is -0.56, indicating that the AS increases when the local signal strength fades. The paper also shows the results for a direction of arrival (DoA) algorithm, which is designed for downlink beamsteering in a GSM related system. The results indicate that an averaging window size of one SACCH frame (0.48 s) is a wise choice for DoA estimation in a non-FH network.
Optical Antennas for Vector Near-Field Imaging (2009)

A new method for nano-engineering the optical antenna properties of scanning probe tips by combining focused ion beam milling with nano-CVD is presented. We demonstrate the capabilities by probing specific vector-field components of plasmonic nanostructures.
Definitive identification of the structures of dicyclopentadienyldiiron tetracarbonyl in solution (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDefinitive identification of the structures of dicyclopentadienyldiiron tetracarbonyl in solutionJ. G. Bullitt, F. Albert Cotton, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1970, 92, 7, 2155–2156Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ja00710a070https://doi.org/10.1021/ja00710a070research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Antitumor cellular immunotherapy: the breakthrough of dendritic cells]. (2000)

Introduction et bases rationnelles L’immunotherapie cellulaire, hier et aujourd’hui Le terme d’immunotherapie cellulaire a ete utilise initialement pour designer le transfert adoptif de cellules effectrices du systeme immunitaire dans le but d’augmenter ou de restaurer une reponse immune antitumorale. Cette forme d’immunotherapie, dite « passive », a ete opposee a l’approche, dite « active », visant a l’induction in vivo, chez un hote porteur de cancer, d’une immunisation antitumorale. Developpee en cancerologie au debut des annees quatre-vingt sur la base des travaux de l’equipe de S. Rosenberg, l’immunotherapie cellulaire adoptive a ete principalement appliquee a la generation et a l’expansion ex vivo, par culture des cellules mononucleees peripheriques en presence de fortes doses d’interleukine 2 (IL2), de cellules dites lymphokine-activated killer (LAK), possedant de fortes capacites de cytotoxicite in vitro contre des lignees tumorales, et efficaces in vivo dans divers modeles murins [1]. Chez l’homme, les essais cliniques reposant sur la reinjection de cellules LAK et d’IL2 ont permis d’obtenir des resultats encourageants dans certains cancers avances et refractaires, en particulier le melanome malin et l’adenocarcinome renal [2]. D’emblee, il est cependant apparu evident que les LAK, exercant essentiellement une activite cytolytique non complexe majeur d’histocompatibilite (CMH)-restreinte, ne constituaient pas une population cellulaire specifique de la tumeur autologue. Les efforts ont alors porte sur l’expansion des populations lymphocytaires infiltrant la tumeur, au contact de laquelle des cellules T specifiques pourraient etre amplifiees. Grâce a une methode de culture et d’expansion des tumor-infiltrating lymphocyte (TIL) a partir de biopsies tumorales de melanome, sarcome et adenocarcinome, les essais cliniques initiaux ont pu rapporter des taux de reponses objectives interessants (de l’ordre de 30 a 40 %) correles a l’existence dans les preparations de TIL d’une activite cytolytique contre la tumeur autologue [3, 4]. Les resultats de ces essais pionniers n’ont cependant pas ete confirmes, en particulier dans les etudes de phase II randomisees ulterieures [5, 6]. Ces premieres tentatives d’immunotherapie cellulaire ont ete freinees par les obstacles methodologiques, les resultats cliniques finalement decevants, enfin leurs couts eleves dans un contexte reglementaire devenu de plus en plus strict. Ces difficultes sont actuellement en passe d’etre resolues.
DSD: Dense-Sparse-Dense Training for Deep Neural Networks (2016)

Modern deep neural networks have a large number of parameters, making them very hard to train. We propose DSD, a dense-sparse-dense training flow, for regularizing deep neural networks and achieving better optimization performance. In the first D (Dense) step, we train a dense network to learn connection weights and importance. In the S (Sparse) step, we regularize the network by pruning the unimportant connections with small weights and retraining the network given the sparsity constraint. In the final D (re-Dense) step, we increase the model capacity by removing the sparsity constraint, re-initialize the pruned parameters from zero and retrain the whole dense network. Experiments show that DSD training can improve the performance for a wide range of CNNs, RNNs and LSTMs on the tasks of image classification, caption generation and speech recognition. On ImageNet, DSD improved the Top1 accuracy of GoogLeNet by 1.1%, VGG-16 by 4.3%, ResNet-18 by 1.2% and ResNet-50 by 1.1%, respectively. On the WSJ'93 dataset, DSD improved DeepSpeech and DeepSpeech2 WER by 2.0% and 1.1%. On the Flickr-8K dataset, DSD improved the NeuralTalk BLEU score by over 1.7. DSD is easy to use in practice: at training time, DSD incurs only one extra hyper-parameter: the sparsity ratio in the S step. At testing time, DSD doesn't change the network architecture or incur any inference overhead. The consistent and significant performance gain of DSD experiments shows the inadequacy of the current training methods for finding the best local optimum, while DSD effectively achieves superior optimization performance for finding a better solution. DSD models are available to download at this https URL.
ADC Quantification of the Vertebral Bone Marrow Water Component: Removing the Confounding Effect of Residual Fat (2016)

By taking into account the presence of residual fat in a modified signal model that incorporates additional individual measurements of PDFF and T<sub>2w</sub> , good agreement of imaging-based ADC with MRS-based ADC can be achieved in vertebral bone marrow. Magn Reson Med 78:1432-1441, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
A phase I trial of humanized monoclonal antibody huA33 in patients with early gastric cancer: Imaging studies, biodistribution, pharmacokinetics, immunohistochemistry, and quantitative tumor uptake (2004)

4142 Background: An open label dose escalation biopsy-based Phase I trial of huA33 in patients with early gastric carcinoma Methods: Thirteen patients were entered onto one of four dose levels (1.0, 2.0, 5.0, 10.0mg/m2.Patients with early gastric carcinoma received infusion of 131I-huA33 one week prior to surgery. Adverse events, imaging studies, biodistribution, tumor biopsies, and immunohistochemical analysis were performed and evaluated. Results: No dose-limiting toxicity was observed during the trial; the maximum tolerated dose was therefore not reached. Although cancer tissues with (+) or (±) by immunostaining in biopsied frozen sections did not show positive imaging or postoperative dosimetry findings, cancers with (++) or (+++) by frozen and paraffin sections in the biopsied specimen showed positive ex-vivo scan and positive antigen expression in resected gastric cancer specimen, and the biodistribution of the huA33 showed uptake of 131I-huA33. Conclusions: Humanized monoclonal antibody huA33 demonstrated selective localization to gastric cancer that strongly expresses A33 antigen. These excellent targeting characteristics of the huA33 indicate potential for the targeted therapy of advanced gastric cancer that is refractory to cytotoxic therapy, and could also be exploitable for curatively resected early gastric cancer in an adjuvant setting. No significant financial relationships to disclose.
Broadband ultra-compact nanophotonic optical modulators and switches (2008)

As multi-core processor architectures continue to evolve as a promising platform for high-performance computing, an additional set of challenges emerges for the global interconnects between cores. In particular, the limited throughput and large power consumption of electrical interconnects become dominant factors limiting the continued scaling of power performance. One promising solution is to replace conventional global interconnects with a CMOS-compatible intra-chip optical network, based on Silicon-On-Insulator (SOI) nanophotonic integrated circuits.
Photo Responses of Pure and Doped Rutile (1980)

Photoconductivity, photosensitized electron spin resonance (ESR), and photosensitized electrochemical reactions of pure and doped rutile are summarized. The first two measurements have revealed the energies of metastably occupied, localized states—both native-defect and impurity 3dn states—relative to the band edges. Electrochemical studies suggest the general shape of the density of donor surface states in reduced rutile; they also reveal both a fast (t1/2 < 0.1 sec) anodic and a slow (t ≈ 10 sec) cathodic photocurrent in rutile photosensitized with [Ru(bipy)3]Cl2. The data are related to the questions of localized versus itinerant 3d electrons in oxides, the possible formal valence states of transition metal ions, and the design of a suitable anode for the photoelectrolysis of water with sunlight.
Emphysema-associated Autoreactive Antibodies Exacerbate Post–Lung Transplant Ischemia–Reperfusion Injury (2018)

Chronic obstructive pulmonary disease-associated chronic inflammation has been shown to lead to an autoimmune phenotype characterized in part by the presence of lung autoreactive antibodies. We hypothesized that ischemia-reperfusion injury (IRI) liberates epitopes that would facilitate preexisting autoantibody binding, thereby exacerbating lung injury after transplant. We induced emphysema in C57BL/6 mice through 6 months of cigarette smoke (CS) exposure. Mice with CS exposure had significantly elevated serum autoantibodies compared with non-smoke-exposed age-matched (NS) mice. To determine the impact of a full preexisting autoantibody repertoire on IRI, we transplanted BALB/c donor lungs into NS or CS recipients and analyzed grafts 48 hours after transplant. CS recipients had significantly increased lung injury and immune cell infiltration after transplant. Immunofluorescence staining revealed increased IgM, IgG, and C3d deposition in CS recipients. To exclude confounding alloreactivity and confirm the role of preexisting autoantibodies in IRI, syngeneic Rag1<sup>-/-</sup> (recombination-activating protein 1-knockout) transplants were performed in which recipients were reconstituted with pooled serum from CS or NS mice. Serum from CS-exposed mice significantly increased IRI compared with control mice, with trends in antibody and C3d deposition similar to those seen in allografts. These data demonstrate that pretransplant CS exposure is associated with increased IgM/IgG autoantibodies, which, upon transplant, bind to the donor lung, activate complement, and exacerbate post-transplant IRI.
A Quad-Output Elastic Switched Capacitor Converter and Per-Core LDO with 87% Power Efficiency and 2.5× Core-Frequency Range Improvement (2020)

A quad-output elastic switched capacitor converter with four cores and per-core digital low dropout regulators (LDOs) is designed in 130nm CMOS. This design routes power on demand by sharing the total switching capacitance network across all the cores and delivering power to each core in a time interleaved manner. As the current demand of a core increases, more switching capacitance and switch area resources are automatically allotted to the core. In case of further power demand, if the power delivery module can no longer allocate further resources, then it autonomously changes the voltage conversion ratio till the demand is met. Measurements reveal 87% peak power efficiency and 2.5× increase in core-frequency range, thus enabling wider dynamic voltage and frequency scaling (DVFS).
How a Multidisciplinary ‘One Health’ Approach can Combat the Tick-Borne Pathogen Threat in Europe (2015)

In Europe, ticks are the major arthropod vectors of disease agents to humans and domestic animals. They are capable of transmitting many pathogens most of which have been discovered or identified as tick-borne pathogens in the last 20 years. In recent years, unexplained syndromes occurring after a tick bite have become an increasingly important issue in public and animal health. Ticks and wildlife (the main reservoir of tick-borne pathogens) are highly susceptible to global environmental and socio-economic changes, which in turn may lead to an increased burden of tick-borne diseases. In this review, we explain the importance of a 'One Health' approach to better combat tick-borne diseases.
N-face GaN/AlGaN Transistors Through Substrate Removal (2008)

In this paper, we present a new method to fabricate N-face GaN/AlGaN HEMTs based on the substrate removal of a Ga-face AlGaN/GaN layer grown on Si. A new substrate removal and transfer technology with no degradation to the GaN active layer. This technology has allowed the fabrication of N-face GaN transistors with record sheet resistance values. The Ga-face surface was bonded to a Si carrier wafer by using a hydrogen silsesquioxane (HSQ) interlayer. HSQ is a flowable oxide with excellent thermal stability.
A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene (2011)

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.
Simple, rapid and cost-effective drug-susceptibility testing of leukemia by intelligent whole-blood imaging flow cytometry (Conference Presentation) (2020)

We present an extreme-throughput (>1 million cells per second) imaging flow cytometer with deep learning to achieve a highly simple, rapid, and cost-effective liquid biopsy for ex-vivo drug-susceptibility testing of leukemia. The drug resistance of leukemia cells was detected in whole blood with only 24-hour drug treatment without hemolysis or dilution, making the sample preparation extremely simple, rapid and cost-effective. Our method also accurately evaluated the drug susceptibility of white blood cells from untreated patients with acute lymphoblastic leukemia, holding great promise for affordable precision medicine.
HYDRATED ELECTRON FORMATION ON LASER EXCITATION OF P‐PYRIDOXYL AMINO ACIDS and PROTEINS (1991)

Evidence from a characteristic transient spectrum, its lifetime and quenching by N2O demonstrates that XeCl excimer laser excitation of the reduced form of pyridoxal 5'-phosphate bound to lysine residues will produce the hydrated electron. The phenoxyl-type radical coproduct was also observed. The results identify a useful label of protein structures for site-specific electron generation which can occur outside the region of light absorption by aromatic residues of protein. The results also represent the first observation of hydrated electron formation from flash excitation of a vitamin B6 cofactor.
Supplementary Table D from Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215 (2023)

Supplementary Table D from Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215
Heterogeneous Microinfarcts Caused by Coronary Microemboli: Evaluation with Multidetector CT and MR Imaging in a Swine Model (2010)

Modern multidetector CT and MR imaging are sensitive modalities with which to depict heterogeneous microinfarcts and determine regional LV dysfunction and decreased perfusion in the territory of intervention. (c) RSNA, 2010.
P3599Minicare high sensitivity troponin: a novel point-of-care tool to improve ACS workflows (2019)

Abstract Background Cardiac troponin (cTn) has been broadly accepted as the biomarker of choice in the diagnosis of patients presenting with Acute Coronary Syndrome (ACS). Point-of-care (POC) cTn testing, defined as testing near the patient with rapid availability of results, has attracted a strong interest in the emergency department (ED) setting. It offers the potential to improve workflows, expedite clinical decisions and to reduce the length of stay. Workflows could be further optimized when a first measurement can already be performed by the emergency medical services prior to admission to the hospital. Advances in assay technology have led to high sensitive (HS) cTn assays that have a profound impact on clinical practice, providing early results at presentation and 1 hour after admission which speed up clinical decision-making. Here we evaluate the Minicare HS cTnI POC test under development, which has the potential to combine the benefits of HS-cTnI protocols with a POC workflow. Objective Evaluate the analytical and clinical capability of the Minicare HS-cTnI test under development to meet the criteria‡ for HS cTn of having a 10% CV &lt;99th percentile and a percentage measurable (&gt;LoD) of &gt;50%. Methods The evaluation is based on the Clinical Laboratory Standards Institute (CLSI) guidelines. Li-heparin whole blood and Li-heparin plasma samples were used to establish LoB, LoD, and LoQ, sample matrix comparison and linearity in the low range. The clinical performance for Minicare HS-cTnI was assessed and compared to Abbott Architect high-sensitivity troponin using banked samples from patients with ACS and collected at t=2–4h after admission. The percentage measurable was assessed and compared to Abbott Architect high-sensitivity troponin in a healthy population of 165 individuals. Results With a time to result within 10 minutes, the LoB is determined at 1.0 ng/L and the LoD at 2.1 ng/L. Plasma and whole blood results correlated well and showed comparable results. The 10% and 20% CV LoQ are established at 7.9 ng/L and 3.1 ng/L, well below the anticipated 99th percentile of 26 ng/L. With a percentage measurable of 77%, the criteria for a HS-cTnI assay are met in a POC device. A sensitivity of 93% and an NPV of 99% are found for Minicare HS-cTnI for a t=2–4h protocol vs 90% and 98% for Abbott Architect high-sensitivity troponin. In this study the area under the curve is 0.98 for Minicare HS-cTnI and 0.97 for Architect HS-cTnI. ROC curve t=2-4 h Conclusions With HS-cTnI capability on the Minicare platform, we show the potential to support a 0/1 h sampling protocol, combined with the speed of a POC workflow. This may enable even more rapid and safe rule-out of patients with ACS.