gebhart/patrepeval huggingface dataset:
Intergrown New Zeolite Beta Polymorphs with Interconnected 12-Ring Channels Solved by Combining Electron Crystallography and Single-Crystal X-ray Diffraction (2012)

Two new polymorphs of zeolite beta, denoted as SU-78A and SU-78B, were synthesized by employing dicyclohexylammonium hydroxides as organic structure-directing agents. The structure was solved by combining transmission electron microscopy and single-crystal X-ray diffraction. SU-78 is an intergrowth of SU-78A and SU-78B and contains interconnected 12-ring channels in three directions. The two polymorphs are built from the same building layer, similar to that for the zeolite beta family. The layer stacking in SU-78, however, is different from those in zeolite beta polymorph A, B, and C, showing new zeolite framework topologies. SU-78 is thermally stable up to 600 °C.
Paving the Way Toward Mobile IAB: Problems, Solutions and Challenges (2022)

Deploying access and backhaul as wireless links, a.k.a. integrated access and backhaul (IAB), is envisioned as a viable approach to enable flexible and dense networks. Even further, mobile IAB (mIAB) is a candidate solution to enhance the connectivity of multiple user equipment (UE) moving together. In this context, different of other works from the literature, the present work overviews the basis for the deployment of mIAB by presenting: 1) the current status of IAB standardization in the fifth generation (5G) new radio (NR); 2) a new taxonomy for state-of-the-art works regarding fixed IAB and mIAB; 3) an extensive performance analysis of mIAB based on simulation results; and 4) open challenges and potential future prospects of mIAB. Specifically, the proposed taxonomy classifies IAB works according to different perspectives and categorizes mIAB works according to the type of mobile node. For each type of mobile node, the main studied topics are presented. Regarding the performance evaluation, we consider an urban macro scenario where mIAB nodes are deployed in buses in order to improve the passengers’ connection. The results show that, compared to other network architectures, the deployment of mIAB nodes remarkably improves the passengers’ throughput and latency in both downlink and uplink.
Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. VOLUME 283 (2008) PAGES 27644-27652 (2009)

Dr. Bao's name was inadvertently omitted from the list of authors. The correct author list is shown above. Dr. Bao's affiliation is as follows: Department of Pharmacology, Xuzhou Medical College, Tongshan Road 209, Xuzhou 221004, Jiangsu Province, China.
Abstract 3207: Application of an antibody-free, highly sensitive PRISM-SRM proteomics approach for monitoring low abundance proteins and protein isoforms in cell lines and tumor tissue. (2013)

Abstract Stable-isotope dilution coupled to targeted mass spectrometry, applying selected reaction monitoring (SRM), provides good selectivity, reproducibility, and sensitivity rendering it highly suitable for robust and high-throughput protein quantification. Historically, SRM sensitivity for measuring protein concentration in biofluids such as blood plasma has been limited to the low μg/mL level. Application of front-end sample preparation methods such as immunoaffinity depletion and strong cation exchange (SCX) chromatographic fractionation has improved the SRM detection limit to low ng/mL level. The ability to detect and quantify low abundance proteins present in blood plasma/serum at sub-ng/mL levels, however, relies on the availability of specific affinity reagents (e.g., antibodies that have the associated disadvantage of an expensive, lengthy, and high failure rate de novo process). To address this limitation, we have recently developed an antibody-free, targeted quantification capability that enables protein quantification of prostate-specific antigen and other exogenous proteins at 50-100 pg/mL levels in plasma/serum. Unlike the traditional SCX fractionation approach where all resulting fractions are analyzed by the second dimension LC-SRM, this new capability, PRISM (high-pressure high-resolution separations with intelligent selection and multiplexing), uses high resolution. Citation Format: Jintang He, Xuefei Sun, Tujin Shi, Athena Schepmoes, Thomas Fillmore, Vladislav Petyuk, Fang Xie, Marina Gritsenko, Feng Yang, Naoki Kitabayashi, Sung Suk Chae, Mark Rubin, Javed Siddiqui, John Wei, Arul Chinnaiyan, Wei-Jun Qian, Richard Smith, Jacob Kagan, Sudhir Srivastava, Tao Liu, Karin Rodland, David Camp. Application of an antibody-free, highly sensitive PRISM-SRM proteomics approach for monitoring low abundance proteins and protein isoforms in cell lines and tumor tissue. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3207. doi:10.1158/1538-7445.AM2013-3207
Identifying optimal indicators and purposes of population segmentation through engagement of key stakeholders: a qualitative study (2020)

The study was approved by the SingHealth Institutional Review Board (CIRB Reference number: 2017/2597).
Supplementary Figure 4 from <i>De novo</i> Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation (2023)

Supplementary Figure 4 from &lt;i&gt;De novo&lt;/i&gt; Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Genome-wide gene expression in experimental arthritis: defining new targets of chronic/destructive rheumatoid arthritis (RA) (2002)

Vascular changes are consistent early findings in patients with SSc and often precede the development of fibrosis. Despite a significant reduction in the capillary density, there is paradoxically no sufficient angiogenesis in the skin of SSc patients. By using a pO 2 histograph, we showed that low pO 2 values are overt in involved skin of patients with SSc. In vitro, real-time PCR revealed a 3.7-fold upregulation of the potent angiogenic growth factor VEGF in SSc fibroblasts after hypoxic exposure compared to normoxic controls. In situ hybridization for VEGF in skin biopsies of patients with SSc showed an overexpression of VEGF mRNA by fibroblasts and mononuclear infiltrates, whereas its expression was limited to keratinocytes in healthy control biopsies. In contrast to the SSc skin, HIF-1 alpha protein was found to be coexpressed with VEGF in healthy skin samples, indicating that the constitutive VEGF synthesis in the skin is driven by this transcription factor. Additionally, we showed that the lack of angiogenesis in SSc is not due to a reduced bioavailability of the overexpressed VEGF, since the VEGF receptors Flk-1 and Flt-1 were found to be expressed on endothelial cells of patients with SSc, but not in healthy controls, and since SSc patients had severely elevated serum levels of VEGF compared to healthy controls. Despite the enhanced levels of VEGF, serum samples of SSc patients did not induce angiogenesis in the vivo chorion allantois membrane assay, indicating that the proangiogenic effects of VEGF may be outweighed by angiostatic factors. The hypothesis that VEGF synthesis has to be above an individual threshold in SSc patients to induce angiogenesis was further strengthened by the finding that patients without fingertip ulcers had significantly higher levels than patients with fingertip ulcers. Interestingly, the angiostatic factor endostatin was elevated in a subset of patients and thus may counteract directly the bio-logic effects of VEGF in SSc patients. Serum levels of VEGF were also correlated significantly with disease severity parameters including antitopoisomerase antibodies. These results suggest that therapeutic application of VEGF by either gene transfer or as a recombinant protein might be a novel option in SSc.
Diet induced atherogenic hyperlipoproteinaemia and liver injury in cynomolgus macaques. (1986)

This study was conducted to determine the efficacy of an experimental anti-atherosclerosis drug in the adult male cynomolgus monkey. A semipurified diet containing 0.5% cholesterol and 25.5% butter was fed to groups of 20, each, drug and placebo-treated animals for 18 months. Similar liver and arterial changes were present in both groups. However, we report here tissue changes seen in animals given placebo only, with plasma lipid and lipoprotein values of placebo-treated animals compared to those in animals fed nonatherogenic commercial ration. Animals fed atherogenic diet had enlarged livers (mean 3.9% b.w.), and all had evidence of hepatocellular lipid accumulation which was often marked and diffuse. Cholangitis was common including mononuclear cell infiltration, bile ductule proliferation and portal tract fibrosis. Five animals had severe portal fibrosis with bands of connective tissue extending into and around lobules (bridging fibrosis). All animals fed atherogenic diet developed hypercholesterolemia (greater than 600 mg/dl) which was the result of a three-fold increase in five cholesterol and cholesterol ester. Oleic acid was increased and linoleic acid was reduced in plasma phospholipids and cholesterol esters. Plasma lipoprotein distribution was altered with a marked increase in low density lipoproteins, increased very low density lipoproteins and decreased high density lipoproteins. These changes were undoubtedly caused by diet, i.e., high in cholesterol and saturated fat and limiting in linoleic acid. It is probable that diet-induced liver injury would affect the pathogenesis of atherosclerosis in this model since the liver is central in the synthesis and metabolism of lipoproteins.
Catabolic effects of endothelial cell‐derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration (2016)

Neovascularization of intervertebral discs, a phenomenon considered pathological since normal discs are primarily avascular structures, occurs most frequently in annulus fibrosus (AF) of degenerated discs. Endothelial cells (ECs) are involved in this process, but the mechanism of the interaction between AF and endothelial cells is unclear. In this study, we evaluated the effects on matrix catabolic activity of AF cells by the extracellular endothelial microparticles (EMPs) and soluble protein factors (SUP fraction) produced from ECs. Passage 1 human AF cells grown in monolayer cultures were treated for 72 h with 250 µg of EMPs or SUP fraction isolated from culture of the microvascular endothelial cell line, HEMC-I. Live-cell imaging revealed uptake of EMPs by AF cells. RT-PCR analysis demonstrated increased mRNA expression of MMP-1 (50.3-fold), MMP-3 (4.5-fold) and MMP-13 (5.5-fold) in AF cell cultures treated with EMPs compared to untreated control. Western analysis also demonstrated increased MMP protein expression in EMP-treated AF cells. AF cells treated with the SUP fraction also exhibited a dramatic increase in MMP mRNA and protein expression. Increased MMP expression is primarily due to EMP or SUP stimulation of AF cells since EMPs or SUP fraction alone contained negligible amount of MMPs. Interestingly, MMP activity was elevated in AF cell cultures treated with EMPs but not with SUP. This study revealed enhanced matrix catabolism as a molecular consequence of action of ECs on AF cells via EMPs, which might be expected during neo-angiogenesis of degenerating disc. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1466-1474, 2016.
Scanning-free imaging through a single fiber by random spatio-spectral\n encoding (2014)

We present an approach for two-dimensional (2D) imaging through a single\nsingle-mode or multimode fiber without the need for scanners. A random\nscattering medium placed next to the distal end of the fiber is used to encode\nthe collected light from every imaged pixel with a different random spectral\nsignature. 2D objects illuminated by a white-light source are then imaged from\na single measured spectrum at the fiber's proximal end. The technique is\ninsensitive to fiber bending, an advantage for endoscopic applications.\n
ChemInform Abstract: TOTAL SYNTHESIS OF (+)‐PIPOXIDE AND (+)‐β‐SENEPOXIDE AND THEIR DIENE PRECURSORS (1985)

Abstract In einer vom Bromlacton (I) ausgehenden Synthesefolge werden die im Titel genannten Verbindungen hergestellt.
ETL, a Novel Seven-transmembrane Receptor That Is Developmentally Regulated in the Heart (2001)

Using differential display of rat fetal and postnatal cardiomyocytes, we have identified a novel seven-transmembrane receptor, ETL. The cDNA-predicted amino acid sequence of ETL indicated that it encodes a 738-aa protein composed of a large extracellular domain with epidermal growth factor (EGF)-like repeats, a seven-transmembrane domain, and a short cytoplasmic tail. ETL belongs to the secretin family of G-protein-coupled peptide hormone receptors and the EGF-TM7 subfamily of receptors. The latter are characterized by a variable number of extracellular EGF and cell surface domains and conserved seven transmembrane-spanning regions. ETL mRNA expression is up-regulated in the adult rat and human heart. In situ hybridization analyses revealed expression in rat cardiomyocytes and abundant expression in vascular and bronchiolar smooth muscle cells. In COS-7 cells transfected with Myc-tagged rat ETL, rat ETL exists as a stable dimer and undergoes endoproteolytic cleavage of the extracellular domain. The proteolytic activity can be abolished by a specific mutation, T455A, in this domain. In transfected mammalian cells, ETL is associated with cell membranes and is also observed in cytoplasmic vesicles. ETL is the first seven-transmembrane receptor containing EGF-like repeats that is developmentally regulated in the heart.
Recent advances in near-field optics: instrumental and applications (1996)

We present a recently constructed near field scanning optical microscope. This microscope features an ultrafine tip/sample approach using a 4:1 mechanical gear reduction of an 80 pitch thread giving an effective pitch of 320. The piezo-driven 12 /spl mu/m x-y scan range is complimented by a generous 4 mm coarse mechanical translation range in each direction. The construction materials used in the feedback loop have been carefully chosen for thermal compatibility to reduce differential expansion and contraction between the tip and sample. A novel pressure-fit sample mounting allows for quick and reliable sample exchange.
Case Report: Delayed Onset Multi-Organ Toxicities in a Melanoma Patient Achieving Complete Response to BRAF/MEK Inhibition (2022)

Autoimmune toxicities, while common following treatment with cancer immunotherapies, are not well-characterized in patients treated with BRAF/MEK inhibitors. Emerging data suggest that autoimmune effects may be linked with superior responses to both treatment modalities; however, there is little evidence describing mechanisms of immune-related toxicity for patients on BRAF/MEK inhibitors. Here we describe the experience of a 59-year-old HLA-A2, A29, B27-positive male with recurrent/metastatic melanoma. After progression on checkpoint inhibitor therapy, he was treated with dabrafenib/trametinib followed by encorafenib/binimetinib, which were well-tolerated and resulted in a complete response. Eighteen months into BRAF/MEK inhibitor therapy, and three months after initially finding a complete response, he developed a series of sudden-onset, severe toxicities: namely, bilateral panuveitis, cytopenias, joint pain, skin rash, hypercalcemia, and interstitial nephritis, which led to BRAF/MEKi cessation. Immunological analyses revealed induction of a peripheral type-17 cytokine signature characterized by high IL-23, IL-6, IL-10, IL-17A/F, IL-1β, and IL-21 among other cytokines in plasma corresponding with the height of symptoms. These findings highlight a novel instance of delayed autoimmune-like reaction to BRAF/MEK inhibition and identify a possible role for Th/Tc17 activation in their pathogenesis thus warranting future clinical and immunological characterization.
Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids (2022)

An aminooxy click chemistry (AOCC) strategy was used to synthesize nucleoside building blocks for incorporation during solid-support synthesis of oligonucleotides to enable bis-homo and bis-hetero conjugation of various biologically relevant ligands. The bis-homo aminooxy conjugation leads to bivalent ligand presentation, whereas the bis-hetero conjugation allows the placement of different ligands with either the same or different chemical linkages. This facile synthetic methodology allows introduction of two different ligands with different biological functions simultaneously.
1P157 Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006)

A serie$ of L-nitroarginine-based dipeptide inhibitors are highll, selective foT neuronal ninic oxide synthuse <nNOS) oyer the endothelial isolbrm (cNOS).
DONOR DOPAMINE FOR THE PREVENTION OF DELAYED GRAFT FUNCTION AFTER RENAL TRANSPLANTATION: A RANDOMIZED CONTROLLED TRIAL (2008)

Schnuelle, P1; Goettmann, U1; Hoeger, S1; Brinkkoetter, P1; Boesebeck, D2; Lauchart, W3; Smith, M4; Rahmel, A4; van der Woude, F1; Yard, B1 Author Information
Ultra-Fast Optical Signal Encoding and Analysis for Communications and Data Fusion Networks (2000)

Abstract : We describe the distributed Bragg pulse shaper, the quantum dot spectrometer and interferometric imaging systems developed under this program. The distributed Bragg pulse shaper is a series of partially reflecting Bragg mirrors constructed over an integrated optical waveguide. Through parallel electrical modulation of the Bragg mirror resonances one can encode terahertz bandwidth optical signals with this device. Quantum dot detectors and interferometric sensors provide complementary technologies for detecting such signals. Quantum dot spectrometers combine the spectral discrimination of quantum confined absorption with resonant tunneling for channel isolation. Interferometric systems map spectral or temporal signal features onto spatially separate channels. In this sense, interferometry acts as a serial-to-parallel complement to the parallel-to-serial action of the pulse shaper.
Follicular dendritic cell–dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion–mediated Bim down-regulation through induction of microRNA-181a (2010)

Follicular dendritic cells (FDCs), an essential component of the lymph node microenvironment, regulate and support B-lymphocyte differentiation, survival, and lymphoma progression. Here, we demonstrate that adhesion of mantle cell lymphoma and other non-Hodgkin lymphoma cells to FDCs reduces cell apoptosis and is associated with decreased levels of the proapoptotic protein, Bim. Bim down-regulation is posttranscriptionally regulated via up-regulation of microRNA-181a (miR-181a). miR-181a overexpression decreases, whereas miR-181a inhibition increases Bim levels by directly targeting Bim. Furthermore, we found that cell adhesion-up-regulated miR-181a contributes to FDC-mediated cell survival through Bim down-regulation, implicating miR-181a as an upstream effector of the Bim-apoptosis signaling pathway. miR-181a inhibition and Bim upregulation significantly suppressed FDC-mediated protection against apoptosis in lymphoma cell lines and primary lymphoma cells. Thus, FDCs protect B-cell lymphoma cells against apoptosis, in part through activation of a miR-181a-dependent mechanism involving down-regulation of Bim expression. We demonstrate, for the first time, that cell-cell contact controls tumor cell survival and apoptosis via microRNA in mantle cell and other non-Hodgkin lymphomas. Regulation of microRNAs by B-cell-FDC interaction may support B-cell survival, representing a novel molecular mechanism for cell adhesion-mediated drug resistance and a potential therapeutic target in B-cell lymphomas.
Influence of Seasons, Extenders, Slow and Rapid Freezing on Seminal Characters in Korean Native Bucks (2006)

The success of AI technology is based on both semen quality and freezing process. In order to establish the semen freezing techniques in Korean native bucks, factors affecting the success were evaluated in the present study. Semen collected by electro-ejaculation from bucks during four distinct seasons was evaluated for semen volume and pH, sperm motility and survivability. The semen volume, concentration and total cell were higher in spring, summer and less in winter. Yet, there were no seasonal differences in the proportional data of live sperm, motility score and pH of semen among seasons. The percentage of live sperm after thawing was found to increase with increased concentration of lactose in Tris-Egg yolk-glycerol (TY-G), being highest in TY-G supplemented with 180 mm lactose (TYL180-G), but did not differ between TY-G and TYL120-G. Sperm motility was enhanced by employing 2.0 h equilibration time with rapid freezing method. In conclusion, semen could be frozen with high success rates for further use of AI in breeding techniques and to preserve the Korean native bucks.
Structure and strength of a polyethylene pipe grade containing glass spheres and low‐molar‐mass linear polyethylene (1997)

Abstract The resistance to slow crack growth and to internal over‐pressure of pipes based on a commercial polyethylene gas pipe grade (BPE; 0.6 mol% butyl branches and M̄ W = 197,000 g/Mol) blended with both an injection molding grade linear polyethylene (LPE; M̄ W = 42,000 g/mol) and 0.5 ± 0.1 mm glass spheres was studied. The blends and the pure polymer components were characterized by density measurements, differential scanning calorimetry, small‐angle X‐ray scattering, and transmission electron microscopy. The fracture properties of extruded pipes were measured using hydrostatic pressure testing and notched uniaxial testing on samples cut from the pipe wall. The polymer components were macroscopically uniformly blended and differential scanning calorimetry indicated the occurrence of partial co‐crystallization between the branched and linear components. Transmission electron microscopy showed molar mass segregation on a 100 nm level. Notched uniaxial testing showed that the slow crack growth resistance of pure BPE was considerably higher than that of the LPE/BPE blend with 30% LPE. Fractography indicated that the fracture‐initiating particles were larger in pipes failing after shorter period of time in the hydrostatic pressure testing. The lifetimes of hydrostatic pressure tested pipes based on the BPE grade containing glass spheres were similar to those of pipes based on the LPE/BPE blend with 30% LPE.
Phase Matched Generation of Coherent Soft-X-rays (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Rundquist, C. G. Durfee III, Z. Chang, C. Heme, S. Backus, M. M. Murnane, and H. C. Kapteyn, "Phase Matched Generation of Coherent Soft-X-rays," Optics & Photonics News 9(12), 54-55 (1998) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article