gebhart/patrepeval huggingface dataset:
Balloon-Assisted Tracking to Overcome Radial Spasm during Transradial Coronary Angiography: A Case Report (2014)

Spasm of the radial artery is the most important cause of failure to perform coronary angiography via the transradial approach. Spasmolytic cocktail may prevent radial artery spasm but is relatively contraindicated in patients with aortic stenosis or diminished left ventricular function. In this case report we describe a recently published technique to overcome severe radial spasm during transradial coronary angiography in a patient with moderate aortic valve stenosis.
Surface Plasmon mediated photoluminescence in gold nanoparticle (2006)

International audience
Towards Robust Visual Odometry with a Multi-Camera System (2018)

We present a visual odometry (VO) algorithm for a multi-camera system and robust operation in challenging environments. Our algorithm consists of a pose tracker and a local mapper. The tracker estimates the current pose by minimizing photometric errors between the most recent keyframe and the current frame. The mapper initializes the depths of all sampled feature points using plane-sweeping stereo. To reduce pose drift, a sliding window optimizer is used to refine poses and structure jointly. Our formulation is flexible enough to support an arbitrary number of stereo cameras. We evaluate our algorithm thoroughly on five datasets. The datasets were captured in different conditions: daytime, night-time with near-infrared (NIR) illumination and nighttime without NIR illumination. Experimental results show that a multi-camera setup makes the VO more robust to challenging environments, especially night-time conditions, in which a single stereo configuration fails easily due to the lack of features.
An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein (2011)

The prion protein gene PRNP directs the synthesis of one of the most intensively studied mammalian proteins, the prion protein (PrP). Yet the physiological function of PrP has remained elusive and has created controversies in the literature. We found a downstream alternative translation initiation AUG codon surrounded by an optimal Kozak sequence in the +3 reading frame of PRNP. The corresponding alternative open reading frame encodes a polypeptide termed alternative prion protein (AltPrP) with a completely different amino acid sequence from PrP. We introduced a hemagglutinin (HA) tag in frame with AltPrP in PrP cDNAs from different species to test the expression of this novel polypeptide using anti-HA antibodies. AltPrP is constitutively coexpressed with human, bovine, sheep, and deer PrP. AltPrP is localized at the mitochondria and is up-regulated by endoplasmic reticulum stress and proteasomal inhibition. Generation of anti-AltPrP antibodies allowed us to test for endogenous expression of AltPrP in wild-type human cells expressing PrP. By transfecting cells with siRNA against PrP mRNA, we repressed expression of both PrP and AltPrP, confirming endogenous expression of AltPrP from PRNP. AltPrP was also detected in human brain homogenate, primary neurons, and peripheral blood mononuclear cells. These results demonstrate an unexpected function for PRNP, which, in addition to plasma membrane-anchored PrP, also encodes a second polypeptide termed AltPrP.
Increased doses of an anti-CD30 antibody, MDX-060, results in prolonged progression free survival in subjects with CD30 positive lymphoma. (2008)

5525 MDX-060 is a human anti-CD30 IgG1kappa monoclonal antibody that inhibits the growth of CD30+ lymphoma cells. To determine the safety and efficacy of MDX-060 in patients with relapsed or refractory CD30+ lymphomas, MDX-060 was administered intravenously at doses of 0.1, 1, 5, 10 or 15 mg/kg weekly for 4 weeks in a phase I/II clinical trial. As previously reported, 72 patients were included in the study - 3 patients received 0.1mg/kg, 16 patients 1mg/kg, 20 patients 5mg/kg, 16 patients 10mg/kg and 17 patients received 15mg/kg. Treatment with MDX-060 was well tolerated with few side effects, however only 6 patients had a clinical response to therapy. Based on the premise that interference with CD30 signaling may result in the arrest of cell growth rather than lysis of the cell, we have now conducted a further analysis with longer follow up to assess whether higher doses of MDX-060 resulted in increased numbers of patients with stable disease and a longer progression free survival (PFS). When patients treated with doses of MDX-060 ≥10mg/kg (high dose group: n=33) were compared to patients who received doses of MDX-060
Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys (2017)

Highly aerobic organs like the kidney are innately susceptible to ischemia-reperfusion (I/R) injury, which can originate from sources including myocardial infarction, renal trauma, and transplant. Therapy is mainly supportive and depends on the cause(s) of damage. In the absence of hypervolemia, intravenous fluid delivery is frequently the first course of treatment but does not reverse established AKI. Evidence suggests that disrupting leukocyte adhesion may prevent the impairment of renal microvascular perfusion and the heightened inflammatory response that exacerbate ischemic renal injury. We investigated the therapeutic potential of hydrodynamic isotonic fluid delivery (HIFD) to the left renal vein 24 hours after inducing moderate-to-severe unilateral IRI in rats. HIFD significantly increased hydrostatic pressure within the renal vein. When conducted after established AKI, 24 hours after I/R injury, HIFD produced substantial and statistically significant decreases in serum creatinine levels compared with levels in animals given an equivalent volume of saline via peripheral infusion (P<0.05). Intravital confocal microscopy performed immediately after HIFD showed improved microvascular perfusion. Notably, HIFD also resulted in immediate enhancement of parenchymal labeling with the fluorescent dye Hoechst 33342. HIFD also associated with a significant reduction in the accumulation of renal leukocytes, including proinflammatory T cells. Additionally, HIFD significantly reduced peritubular capillary erythrocyte congestion and improved histologic scores of tubular injury 4 days after IRI. Taken together, these results indicate that HIFD performed after establishment of AKI rapidly restores microvascular perfusion and small molecule accessibility, with improvement in overall renal function.
ChemInform Abstract: Phenyl β‐Methoxyacrylates: A New Antimalarial Pharmacophore. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>Dynamic wavefront control in confocal microscopy</title> (1999)

We describe a simple method to impress an arbitrary amplitude and phase distribution onto an optical wave. The approach uses a ferroelectric liquid crystal spatial light modulator. Aberrations present in the optical system are measured and compensated before the system is used to tune the pupil function of a confocal microscope in a variety of ways.
ChemInform Abstract: Controlled Polymerizations with Constrained Geometries (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L’hepcidine, une histoire de fer au cœur du foie (2007)

Un petit peptide hormonal produit par le foie decouvert il y a six ans permet de mieux comprendre jour apres jour les raffinements de la regulation du metabolisme du fer. L’hepcidine est en effet l’hormone du fer tant recherchee : elle agit a distance en reglant, en fonction des besoins de l’organisme, la quantite d’exporteur cellulaire du fer, la ferroportine, controlant ainsi les quantites de fer circulant. La demonstration de son implication dans un grand nombre de maladies liees au metabolisme du fer (en particulier hemochromatoses et anemies inflammatoires) suscite de nombreuses recherches pour permettre l’elaboration de nouvelles strategies therapeutiques. Son mode d’action etant maintenant bien caracterise, les nouveaux enjeux portent sur la regulation de l’expression de l’hormone par les hepatocytes, placant le foie au cœur du metabolisme du fer.
On an (old) idea whose time has come: the use of smart antennas and space-time processing at the mobile (2003)

This paper analyzes the use of smart antennas and space-time signal processing at the mobile. First, we introduce a spatio-temporal channel model from the perspective of a multiple mobile antenna receiver and configured for a bad urban propagation scenario with frequency selective Rayleigh fading, and investigate the cochannel interference conditions in a dense future cellular structure. For this environment, we then conduct a comparative study for a temporal DFE with a preselection diversity switch, and a spatio-temporal DFE that performs joint diversity, equalization, and interference suppression, all for two and three element mobile antenna arrays. Our results indicate that for the given scenario, both techniques yield gains with respect to a single antenna receiver, with the more expensive space-time method often strongly superior to the selection-based approach considered. Finally, we briefly treat a structure of processing cells that can be used for an efficient direct implementation of the spatio-temporal DFE using a QRD type of the recursive least squares algorithm.
A classifier capable of rule refinement (2008)

In ubiquitous environment, too much information is generated from a lot of sensors, and people want to obtain the appropriately classified information from the information. Decision tree algorithm like C4.5 is much useful in the field of data mining or machine learning system. Because this is fast and deduces good result on the problem of classification. This paper proposes three methods using decision tree for solving a classification problem. First, this paper suggest about the extended data expression. Second, a classifier, UChoo, based on the extended data expression is described. Third, this paper is to describe about rule generation. The rules expressed in the newly suggested method have almost the same information contents as compared with the original data set. The information is gotten from the sensors becomes large amount of data as the ubiquitous computation environment develops, therefore it is impossible to keep all information in memory. However, using suggested method, this problem is solved smoothly without losing almost the information.
Rapid protein immobilization for thin film continuous flow biocatalysis (2016)

A versatile enzyme immobilization strategy for thin film continuous flow processing is reported. Here, non-covalent and glutaraldehyde bioconjugation are used to immobilize enzymes on the surfaces of borosilicate reactors. This approach requires only ng of protein per reactor tube, with the stock protein solution readily recycled to sequentially coat >10 reactors. Confining reagents to thin films during immobilization reduced the amount of protein, piranha-cleaning solution, and other reagents by ∼96%. Through this technique, there was no loss of catalytic activity over 10 h processing. The results reported here combines the benefits of thin film flow processing with the mild conditions of biocatalysis.
GS0328 Improvement of Sampling Frequency on Strain Measurement using Oscillator Circuit (2016)

The strain measurement method using a CMOS inverter oscillator circuit including a strain gage is simple and can reduce amplifiers, filters, and A/D converters, because the circuit output, oscillating frequency which relates with resistance changes of a strain gage are measured by a simple pulse counting device. However, the sampling frequency is low (more than 1 second) in this method because this method has used the direct counting method for downsizing and simplifying of the measurement system. In this report, the improvement of the sampling frequency using the reciprocal counting method was proposed and studied. We manufactured a frequency adjusting circuit for reciprocal method. It was shown that, although greatly affected by the contact resistance the sampling frequency was improved to 196Hz.
Response to weed control by four spring wheat genotypes differing in competitive ability (1998)

Increased crop competitiveness may complement existing weed control methods. The objective of this research was to establish whether spring wheat (Triticum aestivum L.) genotypes with contrasting competitive abilities respond differently to weed control levels. Four sibling genotypes differing in competitive ability were grown under simulated weedy conditions and subjected to four weed control levels. The competitive genotypes were superior to the less-competitive genotypes in grain yield under weedy and partially weedy conditions. Key words: Triticum aestivum L., competition, weed control, genotype × weedcontrol interaction
Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS (2017)

The formation of acquired drug resistance is a major reason for the failure of anti-cancer therapies after initial response. Here, we introduce a novel model of acquired oxaliplatin resistance, a sub-line of the non-MYCN-amplified neuroblastoma cell line SK-N-AS that was adapted to growth in the presence of 4000 ng/mL oxaliplatin (SK-N-ASrOXALI4000). SK-N-ASrOXALI4000 cells displayed enhanced chromosomal aberrations compared to SK-N-AS, as indicated by 24-chromosome fluorescence in situ hybridisation. Moreover, SK-N-ASrOXALI4000 cells were resistant not only to oxaliplatin but also to the two other commonly used anti-cancer platinum agents cisplatin and carboplatin. SK-N-ASrOXALI4000 cells exhibited a stable resistance phenotype that was not affected by culturing the cells for 10 weeks in the absence of oxaliplatin. Interestingly, SK-N-ASrOXALI4000 cells showed no cross resistance to gemcitabine and increased sensitivity to doxorubicin and UVC radiation, alternative treatments that like platinum drugs target DNA integrity. Notably, UVC-induced DNA damage is thought to be predominantly repaired by nucleotide excision repair and nucleotide excision repair has been described as the main oxaliplatin-induced DNA damage repair system. SK-N-ASrOXALI4000 cells were also more sensitive to lysis by influenza A virus, a candidate for oncolytic therapy, than SK-N-AS cells. In conclusion, we introduce a novel oxaliplatin resistance model. The oxaliplatin resistance mechanisms in SK-N-ASrOXALI4000 cells appear to be complex and not to directly depend on enhanced DNA repair capacity. Models of oxaliplatin resistance are of particular relevance since research on platinum drugs has so far predominantly focused on cisplatin and carboplatin.
Modulating the Potency of an Activator in a Yeast In Vitro Transcription System (1994)

The intrinsic stimulatory potential or potency of a eukaryotic gene activator is controlled by the interaction between the activation domain and the transcriptional machinery. To further understand this interaction, we undertook a biochemical study to identify parameters that could be used to modulate activator potency. We considered how varying the number of activation domains, their flexibility, and the number of promoter sites affects potency in a yeast nuclear extract. The effects of GAL4 derivatives bearing either one, two, or four herpes simplex virus VP16 activation domains (amino acids 413 to 454) were measured on DNA templates containing one or two GAL4 sites in a Saccharomyces cerevisiae nuclear extract. We found that multimerized VP16 activation domains acted synergistically to increase the potency of the activators. The spacing between the activation domains was critical, such that the increased flexibility imparted by a protein linker contributed to increased activator potency. With highly potent activators, the levels of transcription stimulated on a single site were saturating, whereas the stimulatory effect of weaker activators increased with the number of sites. We discuss how these biochemical studies relate to the mechanism of gene activation and synergy in a yeast in vitro system.
Anti-Mycobacterial Antibiotic Therapy Induces Remission in Active Paediatric Crohn’s Disease (2020)

Crohn's disease is increasing in incidence and prevalence in younger people and is of a particularly aggressive nature. One emerging treatment targets <i>Mycobacterium avium paratuberculosis</i> (MAP), an organism implicated in the causation of Crohn's disease. This study reviewed a cohort of paediatric patients with active Crohn's disease treated with Anti-Mycobacterial Antibiotic Therapy (AMAT). Sixteen paediatric patients, the majority of whom had failed conventional immunosuppressive therapy, were treated with AMAT. Endoscopic remission was scored using the Simple Endoscopic Score for Crohn's Disease and clinical remission was assessed using the Weighted Paediatric Crohn's Disease Activity Index (wPCDAI). Inflammatory blood markers were also routinely recorded. Patients were followed up clinically and endoscopically during treatment after an average of two months (range 1-6) and 17 months (range 2-49), respectively. A significant reduction in both scores assessing clinical improvement (<i>p</i> < 0.001) and mucosal healing (<i>p</i> < 0.0078) was observed at these timepoints; 47% of patients had achieved clinical remission and 63% endoscopic remission. Haemoglobin and serum inflammatory markers normalised for more than 50% of the cohort by six months of treatment. No adverse effects were reported throughout treatment. This is the first report of Anti-Mycobacterial Antibiotic Therapy offering a safe and efficacious therapy for paediatric patients with Crohn's disease. Further larger randomised studies are required in order to validate these findings.
Contamination of paper machine press fabric materials by ASA studied with a new deposition tester (2007)

Article Contamination of paper machine press fabric materials by ASA studied with a new deposition tester was published on December 1, 2007 in the journal Nordic Pulp & Paper Research Journal (volume 22, issue 4).
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice (2021)

A shorter treatment time provides the best energy efficiency, and the best reproducibility is obtained for a 10 min treatment duration. The system tested provides an interesting reproducibility in both lung and liver measurements. Our results may help interventional radiologists in the optimal selection of treatment parameters.
Growth behavior of Type I-IR ultrafast laser induced gratings in hydrogen loaded SMF-28 fiber (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. W. Smelser, S. J. Mihailov, and D. Grobnic, "Growth behavior of Type I-IR ultrafast laser induced gratings in hydrogen loaded SMF-28 fiber," in Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper BWB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
[Long-term evolution following shelf procedure for hip dysplasia in adults. Shelf survival analysis in 68 cases and retrospective review of 44 with at least 26 years follow-up]. (1999)

Using Kaplan-Meier's method, the authors found a survival probability of 50% after 25 years in a group of 68 shelf arthroplasties in adult hips. Forty-four shelf procedures, performed at a mean age of 33 years, had sufficient clinical and radiological data to perform a retrospective study with at least 26 years of follow-up. There were 16 dysplastic non-dislocated hips, 19 subluxated hips and 9 dislocated hips. Fifteen shelves (34%) were still in place in 1996 with a mean follow-up of 31.6 years and 29 (66%) underwent reintervention after a mean interval of 20.4 years. The functional result at the latest follow-up, or just prior to reintervention for the reoperated shelves, was good in 13 cases (30%), fair in 28 and poor in 3. Progressive deterioration following shelf procedures was mainly associated with two factors: preoperative congruency (ratio of the largest to smallest joint line thickness), especially if below 0.7, and preoperative osteoarthritis. Reoperation rate climbed from 30% for grade 1 or 2 osteoarthritis, to 73% for grade 3 and to 88% for grade 4. The mean age at the time of reintervention was 54.5 years. Shelf arthroplasties performed for secondary hip osteoarthritis with joint space narrowing (77% in this series) had a mean survival of 20.5 years. The authors believe that a shelf procedure has its place in the conservative surgical management of painful acetabular dysplasia in the adult, even in the presence of osteoarthritis.
Asparagine Metabolic Pathways in Arabidopsis (2015)

Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis. The asparagine amide group is liberated by the reaction catalyzed by asparaginase (ASPG) and also the amino group of asparagine is released by asparagine aminotransferase (AsnAT) for use in the biosynthesis of amino acids. Asparagine plays a primary role in nitrogen recycling, storage and transport in developing and germinating seeds, as well as in vegetative and senescence organs. A small multigene family encodes isoenzymes of each step of asparagine metabolism in Arabidopsis, except for asparagine aminotransferase encoded by a single gene. The aim of this study is to highlight the structure of the genes and encoded enzyme proteins involved in asparagine metabolic pathways; the regulation and role of different isogenes; and kinetic and physiological properties of encoded enzymes in different tissues and developmental stages.
Optical Chirp Chain BOTDA with 150 km sensing range based on Brillouin loss scheme (2022)

Long range distributed optical fiber sensing is urgently needed in many areas, such as pipeline safety, road and bridge monitoring, and so on. Optical chirp chain Brillouin optical time-domain analysis is considered successfully scheme of fast distributed optical fiber sensing, and here, we proposed a fast-monitoring sensing scheme with ultra-long sensing range, which is based on optical chirp chain and Brillouin loss spectrum, and a final parameter of 3.2-s measurement time, 6-m spatial resolution and 150-km sensing range have been achieved over a single-mode fiber.
Asymmetric Total Synthesis of (+)-Coprophilin (2017)

In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.