gebhart/patrepeval huggingface dataset:
Dielectric Response of Cytoplasmic Water and Its Connection to the Vitality of Human Red Blood Cells. II. The Influence of Storage (2017)

Maintaining an appropriate inventory of packaged blood products is a critical part of modern medicine. Consequently, the assessment of red blood cell (RBC) functionality is instrumental for the monitoring of the quality of stored RBC (sRBC) in the blood bank. We present a comprehensive study of sRBC lesion kinetics in SAGM (saline, adenine, glucose, mannitol) solution, using microwave dielectric spectroscopy (0.5-50 GHz) and cell deformability. As part of the research, we have isolated the microwave dielectric response of cytoplasmic water in sRBC. The extracted dielectric parameters are sensitive to the age of the cells and, in particular, to the critical moment of transition from discocyte to echinocyte. From the analysis of the dielectric relaxation as a function of storage-duration, we postulate that the behavior is rooted in the delicate interplay between bound and bulk water in the cellular interior. In particular, the microwave dielectric response reflects the moment when the continuous diffusion of oxygen to the cell and the oxygenation of hemoglobin affects the role played by water in the maintenance of cell integrity. These results open a possible new avenue for the noninvasive inspection of stored red blood cells, permitting a true inventory system for the modern blood bank.
Mixed Micelle Formation through Stereocomplexation between Enantiomeric Poly(lactide) Block Copolymers (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTMixed Micelle Formation through Stereocomplexation between Enantiomeric Poly(lactide) Block CopolymersSung Ho Kim†‡, Jeremy P. K. Tan§, Fredrik Nederberg†‡, Kazuki Fukushima†, Yi Yan Yang§, Robert M. Waymouth‡, and James L. Hedrick*†View Author Information IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120; Department of Chemistry, Stanford University, Stanford, California 94305; and Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669* Corresponding author: Tel 408-927-1632; Fax 408-927-3310; e-mail [email protected]†IBM Almaden Research Center.‡Stanford University.§Institute of Bioengineering and Nanotechnology.Cite this: Macromolecules 2009, 42, 1, 25–29Publication Date (Web):December 15, 2008Publication History Received30 July 2008Revised26 November 2008Published online15 December 2008Published inissue 13 January 2009https://pubs.acs.org/doi/10.1021/ma801739xhttps://doi.org/10.1021/ma801739xrapid-communicationACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views3523Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Micelles,Micellization,Organic polymers,Plastics Get e-Alerts
ChemInform Abstract: Continuous‐Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts. (2013)

Abstract The method involves the diazotation of anilines followed by a Meerwein arylation sequence with ethyl vinyl ether.
Figure 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities (2023)

&lt;p&gt;&lt;b&gt;A,&lt;/b&gt; Mutation combinations represented in H3&lt;sup&gt;K27M&lt;/sup&gt; models and the acronyms used to refer to them. &lt;b&gt;B,&lt;/b&gt; IHC detection of hematoxylin and eosin (H&amp;E), GFP, K27M, and Ki-67 in coronal hindbrain sections from tumor-bearing, symptomatic mice. Embryos were electroporated with vectors encoding (i) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, p53&lt;sup&gt;LOF&lt;/sup&gt; (KP); (ii) H3.1&lt;sup&gt;K27M&lt;/sup&gt;, p53&lt;sup&gt;LOF&lt;/sup&gt; (H3.1KP); (iii) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, FGFR1&lt;sup&gt;N457K&lt;/sup&gt; (KF); (iv) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, NF1&lt;sup&gt;LOF&lt;/sup&gt; (KN); (v) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, p53&lt;sup&gt;LOF&lt;/sup&gt;, FGFR1&lt;sup&gt;N457K&lt;/sup&gt; (KPF); and (vi) H3.3&lt;sup&gt;K27M&lt;/sup&gt;, p53&lt;sup&gt;LOF&lt;/sup&gt;, CCND2&lt;sup&gt;WT&lt;/sup&gt; (KPC). Tumor cells are GFP&lt;sup&gt;+&lt;/sup&gt;. Higher magnification panels below each low-magnification panel are of the tumor bulk in the brainstem, i.e., pons and medulla, which are directly below the cerebellum and fourth ventricle. Scale bars, 2 mm in the low-magnification panels and 200 μm in the high-magnification panels. &lt;b&gt;C,&lt;/b&gt; Kaplan–Meier survival curves of IUE, tumor-bearing mice carrying different combinations of mutations. KP (&lt;i&gt;n&lt;/i&gt; = 6), H3.1KP (&lt;i&gt;n&lt;/i&gt; = 6), KF (&lt;i&gt;n&lt;/i&gt; = 10), KN (&lt;i&gt;n&lt;/i&gt; = 7), KPF (&lt;i&gt;n&lt;/i&gt; = 16), and KPC (&lt;i&gt;n&lt;/i&gt; = 9). Statistical comparisons using the log-rank Mantel–Cox tests are described in Supplementary Table S2.&lt;/p&gt;
Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains: Detergents Destabilize Extramembranous Soluble Domains (2021)

Detergent interaction with extramembranous soluble domains (ESDs) is not commonly considered an important determinant of integral membrane protein (IMP) behavior during purification and crystallization, even though ESDs contribute to the stability of many IMPs. Here we demonstrate that some generally nondenaturing detergents critically destabilize a model ESD, the first nucleotide-binding domain (NBD1) from the human cystic fibrosis transmembrane conductance regulator (CFTR), a model IMP. Notably, the detergents show equivalent trends in their influence on the stability of isolated NBD1 and full-length CFTR. We used differential scanning calorimetry (DSC) and circular dichroism (CD) spectroscopy to monitor changes in NBD1 stability and secondary structure, respectively, during titration with a series of detergents. Their effective harshness in these assays mirrors that widely accepted for their interaction with IMPs, i.e., anionic > zwitterionic > nonionic. It is noteworthy that including lipids or nonionic detergents is shown to mitigate detergent harshness, as will limiting contact time. We infer three thermodynamic mechanisms from the observed thermal destabilization by monomer or micelle: (i) binding to the unfolded state with no change in the native structure (all detergent classes); (ii) native state binding that alters thermodynamic properties and perhaps conformation (nonionic detergents); and (iii) detergent binding that directly leads to denaturation of the native state (anionic and zwitterionic). These results demonstrate that the accepted model for the harshness of detergents applies to their interaction with an ESD. It is concluded that destabilization of extramembranous soluble domains by specific detergents will influence the stability of some IMPs during purification.
High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors. (1977)

From the first day of dimethylbenzanthracene administration, daily treatment with 8 or 24 mug of the new antiestrogen 11alpha-methoxy ethinyl estradiol (RU 16117) completely prevented the appearance of mammary tumors in all animals up to the last time interval studied (130 days after dimethyl benzanthracene administration). At daily doses of 0.5 and 2.0 mug RU 16117, the tumor incidence was reduced to 78.6 and 40%, respectively. Not only was the number of animals developing tumors reduced after injection of low doses of RU 16117, but the number of tumors per rat and the size of tumors were also markedly reduced. The levels of receptors for estradiol, progesterone, and prolactin in tumor tissue were reduced after treatment with 2.0 mug RU 16117, while the binding of growth hormone and insulin was not affected. Whereas plasma luteinizing hormone levels decreased after treatment with 8 or 24 mug RU 16117, plasma prolactin levels slightly increased in animals receiving the highest dose of the antiestrogen. It is thus likely that the potent inhibitory effect of RU 16117 on the development of dimethylbenzanthracene-induced mammary tumors results from actions at both the hypothalamic-pituitary and the tumor (mammary gland) levels, the action at the peripheral level possibly being secondary to a reduced sensitivity of the tissue to circulating hormones through lowering of hormone receptor concentrations.
Control of relative stereochemistry in the cycloadditive route to .beta.-hydroxy carbonyls. Regio- and stereoselective exo alkylation of .DELTA.2-isoxazolines (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTControl of relative stereochemistry in the cycloadditive route to .beta.-hydroxy carbonyls. Regio- and stereoselective exo alkylation of .DELTA.2-isoxazolinesDennis P. Curran and Jyh Chyang ChaoCite this: J. Am. Chem. Soc. 1987, 109, 10, 3036–3040Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ja00244a027https://doi.org/10.1021/ja00244a027research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Free radical polymerization for narrow polydispersity resins: electron spin resonance studies of the kinetics and mechanism. [Erratum to document cited in CA119:160868] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleFree radical polymerization for narrow polydispersity resins: electron spin resonance studies of the kinetics and mechanism. [Erratum to document cited in CA119:160868]Richard P. N. Veregin, Michael K. Georges, Peter M. Kazmaier, and Gordon K. HamerCite this: Macromolecules 1994, 27, 18, 5238Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ma00096a062https://doi.org/10.1021/ma00096a062research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Gas Atmosphere on Graphitization of Carbon Powder (2014)

現在，黒鉛化処理した炭素材は，さまざまな分野で使用されている．しかし，黒鉛化処理には，莫大なエネルギーが必要であり，大気中に炭素ガスなどを放出するという問題を抱えている．そこで本研究では，環境負荷が少なく，電気エネルギーを削減でき，かつ，十分黒鉛化度を上げることができる熱処理方法について検討した．具体的には，炭素材を種々の黒鉛化炉で黒鉛化処理を行い，粉体特性の変化について検討した．その中で，黒鉛化時の雰囲気ガスの影響について着目した．その結果，窒素ガス中での黒鉛化処理は，アルゴンガス中での黒鉛化処理に比べて，黒鉛化が進行し易い事が確認され，また，黒鉛化温度も300˚C低減できた．
Characterization of matteuccin, the 2.2S storage protein of the ostrich fern (1990)

The 2.2S spore storage protein (matteuccin) of the ostrich fern, Matteuccia struthiopteris, has been isolated and characterized. It is a small basic protein consisting of two disulfide-linked polypeptides with approximate molecular masses of 3.0 kDa and 8.0 kDa. At least four different isoforms exist where two of the forms differ from the other by having a slightly smaller heavy chain. Amino acid analysis reveals that the 2.2S protein is rich in arginine. Almost complete amino acid sequence information was obtained for the light chain and a partial sequence for the heavy chain. Amino acid sequence comparison reveals that this protein shows a high similarity to seed storage proteins in different angiosperm species in spite of the fact that the common ancestor of ferns and angiosperms lived more than 300 million years ago.
Replex: a scalable, highly available multi-index data store (2016)

The need for scalable, high-performance datastores has led to the development of NoSQL databases, which achieve scalability by partitioning data over a single key. However, programmers often need to query data with other keys, which data stores provide by either querying every partition, eliminating the benefits of partitioning, or replicating additional indexes, wasting the benefits of data replication.

In this paper, we show there is no need to compromise scalability for functionality. We present Replex, a datastore that enables efficient querying on multiple keys by rethinking data placement during replication. Traditionally, a data store is first globally partitioned, then each partition is replicated identically to multiple nodes. Instead, Replex relies on a novel replication unit, termed replex, which partitions a full copy of the data based on its unique key. Replexes eliminate any additional overhead to maintaining indices, at the cost of increasing recovery complexity. To address this issue, we also introduce hybrid replexes, which enable a rich design space for trading off steady-state performance with faster recovery. We build, parameterize, and evaluate Replex on multiple dimensions and find that Replex surpasses the steady-state and failure recovery performance of Hyper-Dex, a state-of-the-art multi-key data store.
‘Inlet suction’, a load support mechanism in non-convergent, pocketed, hydrodynamic bearings (2006)

It is shown that a simple parallel pad bearing containing a closed pocket can support load if it operates in an ambient pressure that is appreciably in excess of the cavitation pressure of the lubricating fluid. This arises due to fluid flow driven by subambient pressures in the inlet region of the pad (‘inlet suction’). Maximum load capacity occurs when the pocket is located near the inlet to the bearing and under conditions such that cavitation is just provoked.
Codebit parsers for adaptive bit loading over MIMO channels (2006)

Adaptive bit loading (ABL) can be employed to compensate for the signal strength variation across spatial channels in MIMO system that employs SVD beamforming. Due to the significant spread of singular values across the spatial streams, it is beneficial to load each stream with a different number of codebits. In the so called vertically encoded MIMO system, all spatial channels share one channel encoder, and a codebit parser distributes the contiguous codebits into multiple spatial channels, where the ABL scheme determines the load per channel. It is desirable that the codebits in each spatial channel are evenly spaced in the original codeword in order to maximize spatial diversity. The existing block codebit parser (2002) assigns the continuous blocks of codebits to each stream respectively. In the paper, we derive a few codebit parsers, including the optimal one. The simulation results over 802.11n convolutionally coded channels demonstrate the superiority.
Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy (2012)

We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.
On Recursive and Fast Recursive Computation of the Capon Spectrum (2007)

The Capon spectrum, which is known to have better resolution than the periodogram, has been widely used in various applications. Normally, the Capon spectrum is estimated through the direct computation of the inverse of the data correlation (or covariance) matrix. This so-called direct inverse approach is, however, computationally very expensive due to the high computational cost involved in the matrix inversion. This paper deals with fast and efficient algorithms in computing the Capon spectrum. Inspired from the recursive idea established in the area of adaptive signal processing, we first derive a recursive Capon algorithm. This new algorithm does not require an explicit matrix inversion, and hence is more efficient to implement than the direct inverse method. We then develop a fast version of the recursive algorithm, which can further reduce the complexity of the recursive one by an order of magnitude.
End to End Learning based Self-Driving using JacintoNet (2018)

Automated driving functions, like highway driving and parking assist, are getting increasing deployed in high-end cars with the trend moving towards the self-driving car. With the advent of deep learning, many traditional computer vision techniques have been replaced by deep convolutional neural networks (CNN). End to end learning is one of the paradigm for self-driving, in which user provides a input images from the front facing camera to the given neural network and the network outputs the car control signals such as throttle, steering and braking. The paper proposes an embedded friendly convolutional neural network, `Jacintonet', to demonstrate self-driving using end to end learning paradigm in a virtual simulation environment. Paper discusses key learning during the training methodology and presents the results on embedded platform. Texas Instruments (TI) TDA2x System on Chip (SoC) is used as embedded platform for running `Jacintonet', real-time to demonstrate self-driving car in the virtual simulator.
Directional Self‐Assembly of Fluorinated Star Block Polymer Thin Films Using Mixed Solvent Vapor Annealing (2019)

We demonstrate the directional alignment of perpendicular‐lamellae domains in fluorinated three‐armed star block polymer (BP) thin films using solvent vapor annealing with shear stress. The control of orientation and alignment was accomplished without any substrate surface modification. Additionally, three‐armed star poly(methyl methacrylate‐block‐styrene) [PMMA‐PS] and poly(octafluoropentyl methacrylate‐block‐styrene) were compared to their linear analogues to examine the impact of fluorine content and star architecture on self‐assembled BP feature sizes and interdomain density profiles. X‐ray reflectometry results indicated that the star BP molecular architecture increased the effective polymer segregation strength and could possibly facilitate reduced polymer domain spacings, which are useful in next‐generation nanolithographic applications. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1663–1672
Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice (2016)

Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FcεRI. Tumor protection was also lost after depletion of CD8(+) T cells, highlighting a cross-talk between IgE and T cell-mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology.
La critique des spectacles par les diplomates au XVIIe siècle (2023)

This article seeks to examine the diplomatic archive as a rich source for the study of seventeenth-century dramatic criticism. Ambassadors and other foreign ministers made up a privileged sector of the audience for theatrical entertainments staged in European courts and capitals. Documenting their experiences of spectatorship, diplomats’ official correspondence particularly highlights the centrality of sociability in discussions of theater in this period.
Benefit estimation model for pedestrian auto brake functionality (2010)

Accident data show that the vast majority of pedestrian accidents involve a passenger car. A refined method for estimating the potential effectiveness of a technology designed to support the car driver in mitigating or avoiding pedestrian accidents is presented. The basis of the benefit prediction method consists of accident scenario information for pedestrian-passenger car accidents from GIDAS, including vehicle and pedestrian velocities. These real world pedestrian accidents were first reconstructed and the system effectiveness was determined by comparing injury outcome with and without the functionality enabled for each accident. The predictions from Volvo Cars' general benefit estimation model are refined by including the actual system algorithm and sensing models for a relevant car in the simulation environment. The feasibility of the method is proven by a case study on an authentic technology; the auto brake functionality in collision warning with full auto brake and pedestrian detection (CWAB-PD). Assuming the system is adopted by all vehicles, the case study indicates a reduction of 24 percent in pedestrian fatalities for crashes where the pedestrians were struck by the front of a passenger car. (A) Paper to the session Driver Assistant Strategies and Accident Causation of the 4th International Conference on ESAR Expert Symposium on Accident Research, 16th to 18th September 2010 in Hannover. For the covering abstract of the conference, see ITRD D366702.