gebhart/patrepeval huggingface dataset:
A census of the lung: CellCards from LungMAP (2021)

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional properties of existing cell types in lung. The time has come to take a new census. Initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community, we synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication will serve as the starting point of a live, up-to-date guide for lung research at https://www.lungmap.net/cell-cards/. We hope that Lung CellCards will promote the community-wide effort to establish, maintain, and restore respiratory health.
Analytical analysis of the generic SET and RESET characteristics of electrochemical metallization memory cells (2013)

We report on an analytical model which describes the bipolar resistive switching in electrochemical metallization cells. To simulate the resistive switching, we modeled the growth and dissolution of a metallic filament together with electron tunneling between the growing filament and the counter electrode. The model accounts for the controllability of the low resistive state and the RESET current by tuning the SET current. By analytical analysis the relevant conditions for these generic characteristics are identified. In addition, an explanation for the asymmetry in the SET and RESET switching characteristics is presented. The results of the analytical analysis is generalized to all types of ReRAMs.
Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo (2016)

Collectively, these data strongly suggest that targeting RTK-AXL with BMS-777607 could represent a novel and potent regimen for the treatment of primary and recurrent GBM.
Low-noise millimeter-wave synthesis from a dual-wavelength fiber Brillouin cavity (2019)

In this Letter, a photonic system is proposed to generate millimeter waves with low phase noise and ultra-high frequency stability. By locking two free-running CW lasers to the same fiber cavity whose free-spectral range is actively stabilized, millimeter waves can be synthesized in a wide frequency range with fine-tuning capability. Exploiting the spectral narrowing effect of stimulated Brillouin scattering, the generated millimeter waves exhibit low phase noise that does not scale up as the frequency increases. In the experimental demonstration, up to ∼300 GHz millimeter waves are generated, with a phase noise of <-90 dBc/Hz at 10 kHz offset limited by the local oscillator and an in-loop 60 min frequency RMS drift of 0.43 mHz. The output frequency of the system can be readily increased to sub-THz region by replacing one of the pump CW lasers.
Production of nitrogen monochloride(a) by thermal decomposition of chlorine azide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of nitrogen monochloride(a) by thermal decomposition of chlorine azideD. J. Benard, M. A. Chowdhury, B. K. Winker, T. A. Seder, and H. H. MichelsCite this: J. Phys. Chem. 1990, 94, 19, 7507–7514Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/j100382a037https://doi.org/10.1021/j100382a037research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Generating English summaries of time series data using the Gricean maxims (2003)

We are developing technology for generating English textual summaries of time-series data, in three domains: weather forecasts, gas-turbine sensor readings, and hospital intensive care data. Our weather-forecast generator is currently operational and being used daily by a meteorological company. We generate summaries in three steps: (a) selecting the most important trends and patterns to communicate; (b) mapping these patterns onto words and phrases; and (c) generating actual texts based on these words and phrases. In this paper we focus on the first step, (a), selecting the information to communicate, and describe how we perform this using modified versions of standard data analysis algorithms such as segmentation. The modifications arose out of empirical work with users and domain experts, and in fact can all be regarded as applications of the Gricean maxims of Quality, Quantity, Relevance, and Manner, which describe how a cooperative speaker should behave in order to help a hearer correctly interpret a text. The Gricean maxims are perhaps a key element of adapting data analysis algorithms for effective communication of information to human users, and should be considered by other researchers interested in communicating data to human users.
Formability of TS590 N/mm2 “Tri-Phase” Hot Rolled Steel (1993)

&lt;div class="htmlview paragraph"&gt;TS590N/mm&lt;sup&gt;2&lt;/sup&gt; hot rolled steel showing a good balance of stretch formability and stretch flangeability has been newly developed for manufacturing high strength automotive parts. A laboratory study revealed that an introduction of a small amount of martensite in ferrite · bainite microstructure remarkably improves uniform elongation of ferrite · bainite steel giving little influence on its good localized elongation. Characteristics in ductile property of this “Tri-Phase” type steel were confirmed in press forming tests.&lt;/div&gt;
Developing calendar visualizers for the information visualizer (1994)

The increasing mass of information confronting a business or an individual have created a demand for information management applications. Time-based information, in particular, is an important part of many information access tasks. This paper explores how to use 3D graphics and interactive animation to design and implement visualizers that improve access to large masses of time-based information. Two new visualizers have been developed for the Information Visualizer: 1) the Spiral Calendar was designed for rapid access to an individual's daily schedule, and 2) the Time Lattice was designed for analyzing the time relationships among the schedules of groups of people. The Spiral Calendar embodies a new 3D graphics technique for integrating detail and context by placing objects in a 3D spiral. It demonstrates that advanced graphics techniques can enhance routine office information tasks. The Time Lattice is formed by aligning a collection of 2D calendars. 2D translucent shadows provide views and interactive access to the resulting complex 3D object. The paper focuses on how these visualizations were developed. The Spiral Calendar, in particular, has gone through an entire cycle of development, including design, implementation, evaluation, revision and reuse. Our experience should prove useful to others developing user interfaces based on advanced graphics.
High Resolution Separation of Proteins in a Polymeric Micro-Fluidic Chip (2003)

An integrated micro-fluidic chip has been developed using Poly-di-methyl siloxane (PDMS) to separate proteins by isoelectric focusing (IEF). Soft lithography techniques, which offer rapid prototyping, easy multilayer fabrication, mass production capability and biocompatibility, were utilized to fabricate various parts of the micro-fluidic chip. Separately molded PDMS layers were bonded together to form three-dimensional microfluidic chips. The microfluidic chips were prepared for IEF by conditioning the channel with 1 M NaOH and then loading it with a solution of fluorescent proteins made using 0.4% MC, 4% broad-range ampholyte and 0.018 mg/ml protein in 18 MOhm water. Relatively large reservoirs on the acidic and basic ends of the channel were filled with anolyte (50 mM phosphoric acid) and catholyte (50 mM sodium hydroxide), respectively, and then current was applied along the axis of the channel until one or more bands of protein focused, usually in just a few minutes even at relatively low voltages. The focused bands were generally well-formed with sharp edges and were less than 100 microns across yielding a putative peak capacity in excess of 100 peaks in a 2-cm long channel.
Probing Nanotube-Nanopore Interactions (2005)

We demonstrate a new nanoscale system consisting of a nanotube threaded through a nanopore in aqueous solution. Its electrical and mechanical properties are sensitive to experimentally controllable conformational changes on sub-Angstrom length scales. Ionic current transport through a nanopore is significantly suppressed by the threading nanotube and the mechanical interactions between the nanotube and pore are accounted for by a folding geometry. The experiments provide first measurements of the longitudinal resolution and metrology of a solid-state nanopore "microscope." This new nanostructure provides a means to study molecule-nanotube interactions in conducting ionic solutions as well as geometrical and surface properties of nanopores and nanotubes.
Recent results from the Berkeley 0.3-NA microfield exposure tool (2007)

Operating as a SEMATECH resist test center, the Berkeley 0.3-NA EUV microfield exposure tool continues to play a crucial role in the advancement of EUV resists and masks. Here we present recent resist-characterization results from the tool as well as tool-characterization data. In particular we present lithographic-based aberration measurements demonstrating the long-term stability of the tool. We also describe a recent upgrade to the tool which involved redesign of the programmable coherence illuminator to provide improved field uniformity as well as a programmable field size.
Evaluation of a Modified Monod Model for Predicting Algal Dynamics in Lake Tai (2015)

Several modified versions of the Monod model have been proposed to simulate algal dynamics in lakes by keeping the parent model’s advantages of simplicity and low data requirement. This study evaluated the performance of a widely-used modified Monod model in predicting algal dynamics at various time scales in Lake Tai, a typical shallow lake in east China, using multiple time series. Chlorophyll-a (Chl-a) concentration was used as a surrogate for algal (CyanoHABs: cyanobacterial harmful algal blooms) growth and the independent variables were total nitrogen (TN), total phosphorus (TP), and either water temperature or air temperature. The evaluation indicated that the model parameters could have distinctly different values, depending on whether or not constraints are imposed, time scales, and types of nutrients. The model performance varied in terms of time scales as well as magnitudes and fluctuations of Chl-a and TN or TP concentrations, achieving a relative better performance for the monthly rather than three-day time scale and for the central part rather than bays of the study lake. The model with TP as the independent variable had a better performance than the model with TN as the independent variable, regardless of the time scale used. The temperature-nutrient interactions were important for algal growth when the temporal fluctuations of these two factors were large but the interactions could become minimal otherwise.
Investigation of model OPC optimization based on CD uniformity yield (2003)

CDU is probably one of the most important process control parameters for poly gate printing process. As the design rule has been shrunk to below 100nm node and k1 approaching 0.35, the required specifications for CDU are more stringently tightened. For low k1 lithogrpahy, optical proximity effect can severely impact CDU of the cirtical features from different neighboring environments, such as, isolated versus dense regions, or near the crowded corners and intersections, etc. Conventional model OPC has been assumed to correct mask feature CD at a best process setting condition. The approach has been widely adopted but it is increasingly becoming less satisfactory since this method does not take into account the process variation within the acceptable process window. In ASMLs LithoCruiser, for a selected CD cut-line, we use a Monte Carlo approach to randomly generate process conditions within the process window to simulate thousands of CDs. Based on the predicted CD distribution, we can calculate the predicted CDU Yield within the process window. Using LithoCruiser's Application Programming Interface (API) we can set up an optimization loop to adjust mask feature snippets for a desired imaging and process condition to achieve user specified CDU yield. Depending on the neighboring environment, mask snippets with the same target CD may need different biases and so are the features with different target CDs due to different degrees of optical proximity effects.
Hyrtioseragamines A and B, New Alkaloids from the Sponge Hyrtios Species (2011)

Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.
Global optimization of nonconvex mixed-integer nonlinear programming (MINLP) problems in process synthesis (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlobal optimization of nonconvex mixed-integer nonlinear programming (MINLP) problems in process synthesisGary R. Kocis and Ignacio E. GrossmannCite this: Ind. Eng. Chem. Res. 1988, 27, 8, 1407–1421Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ie00080a013https://doi.org/10.1021/ie00080a013research-articleACS PublicationsRequest reuse permissionsArticle Views1417Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Influence of the Si-H2 Bond on the Light-Induced Effect in a-Si Films and a-Si Solar Cells (1989)

The influence of the Si-H 2 bond on light-induced degradation and the thermal recovery of a-Si films and a-Si solar cells were studied. The influence of the Si-H 2 bond on light-induced degradation depends on the impurity content in a-Si films, and light-induced degradation can be reduced by decreasing the Si-H 2 bond density in a-Si films with impurity content of 10 18 cm -3 . The activation energy of the thermal recovery process was about 1.0 eV, and it did not depend on the Si-H 2 bond density. However, an irreversible phenomenon was observed in film properties and solar cell characteristics with high Si-H 2 bond density. It is thought that the structural flexibility of the Si-H 2 bond is related to this irreversible phenomenon.
Mechanism of molecular interactions for tRNAVal recognition by valyl-tRNA synthetase (2003)

The molecular interactions between valyl-tRNA synthetase (ValRS) and tRNA(Val), with the C34-A35-C36 anticodon, from Thermus thermophilus were studied by crystallographic analysis and structure-based mutagenesis. In the ValRS-bound structure of tRNA(Val), the successive A35-C36 residues (the major identity elements) of tRNA(Val) are base-stacked upon each other, and fit into a pocket on the alpha-helix bundle domain of ValRS. Hydrogen bonds are formed between ValRS and A35-C36 of tRNA(Val) in a base-specific manner. The C-terminal coiled-coil domain of ValRS interacts electrostatically with A20 and hydrophobically with the G19*C56 tertiary base pair. The loss of these interactions by the deletion of the coiled-coil domain of ValRS increased the K(M) value for tRNA(Val) 28-fold and decreased the k(cat) value 19-fold in the aminoacylation. The tRNA(Val) K(M) and k(cat) values were increased 21-fold and decreased 32-fold, respectively, by the disruption of the G18*U55 and G19*C56 tertiary base pairs, which associate the D- and T-loops for the formation of the L-shaped tRNA structure. Therefore, the coiled-coil domain of ValRS is likely to stabilize the L-shaped tRNA structure during the aminoacylation reaction.
Performance optimization of room temperature Deflection Transistors through modified geometry (2008)

In this paper, the current status of the ballistic deflection transistor (BDT) project is described. The project focuses on a development of a new class of devices based on the steering of the electron flux and the ballistic deflection effect. The results of the latest experiments show significant current response improvement through optimized geometry modifications.
CRIM-positive mutations of acute intermittent porphyria in Finland (1992)

Acute intermittent porphyria (AIP) is a dominantly inherited metabolic disease caused by a partial deficiency of the third enzyme, porphobilinogen deaminase (PBGD), in the heme biosynthetic pathway. AIP has been divided into two subtypes according to the ratio of enzyme polypeptide concentration and enzyme activity measured in erythrocytes: cross-reacting immunologic material (CRIM) positive or negative. In this study six out of the seven known CRIM-positive AIP families in Finland were analyzed and two also previously identified mutations in the PBGD gene were found to be responsible for AIP in this genetically isolated population. The search for mutations was focused on exon 10 based on previously found mutations. SSCP analysis revealed a known polymorphism but the two mutations in that region were found only by direct sequencing of the PCR products. A G518-->A substitution changing Arg173 to Gln was found in three families and a C499-->T substitution changing Arg167 to Trp was detected in three families. DNA analyses of the family members revealed that conventional assays of erythrocyte PBGD activity identified correctly only 72% of the carriers for the AIP mutation.
Blinding efficacy and adverse events following repeated transcranial alternating current, direct current, and random noise stimulation (2022)

Abstract As transcranial electrical stimulation (tES) protocols advance, assumptions underlying the technique need to be retested to ensure they still hold. Whilst the safety of stimulation has been demonstrated mainly for a small number of sessions, and small sample size, adverse events (AEs) following multiple sessions remain largely untested. Similarly, whilst blinding procedures are typically assumed to be effective, the effect of multiple stimulation sessions on the efficacy of blinding procedures also remains under question. This is especially relevant in multisite projects where small unintentional variations in protocol could lead to inter-site difference. We report AE and blinding data from 1,019 participants who received up to 11 semi-consecutive sessions of active or sham transcranial alternating current stimulation (tACS), direct current stimulation (tDCS), and random noise stimulation (tRNS), at 4 sites in the UK and US. We found that AEs were often best predicted by factors other than tES, such as testing site or session number. Results from the blinding analysis suggested that blinding was less effective for tDCS and tACS than tRNS. The occurrence of AEs did not appear to be linked to tES despite the use of smaller electrodes or repeated delivery. However, blinding efficacy was impacted in tES conditions with higher cutaneous sensation, highlighting a need for alternative stimulation blinding protocols. This may be increasingly necessary in studies wishing to deliver stimulation with higher intensities.
RAB11A Is Essential for Transport of the Influenza Virus Genome to the Plasma Membrane (2011)

Influenza A virus assembly is a complex process that requires the intersection of pathways involved in transporting viral glycoproteins, the matrix protein, and viral genomes, incorporated in the viral ribonucleoprotein (vRNP) complex, to plasma membrane sites of virion formation. Among these virion components, the mechanism of vRNP delivery is the most incompletely understood. Here, we reveal a functional relationship between the cellular Rab11 GTPase isoform, RAB11A, and vRNPs and show that RAB11A is indispensable for proper vRNP transport to the plasma membrane. Using an immunofluorescence-based assay with a monoclonal antibody that recognizes nucleoprotein in the form of vRNP, we demonstrate association between RAB11A and vRNPs at all stages of vRNP cytoplasmic transport. Abrogation of RAB11A expression through small interfering RNA (siRNA) treatment or disruption of RAB11A function by overexpression of dominant negative or constitutively active proteins caused aberrant vRNP intracellular accumulation, retention in the perinuclear region, and lack of accumulation at the plasma membrane. Complex formation between RAB11A and vRNPs was further established biochemically. Our results uncover a critical host factor with an essential contribution to influenza virus genome delivery and reveal a potential role for RAB11A in the transport of ribonucleoprotein cargo.
Feedforward and Repetitive Control for Machine Tool Feed Drives (1989)

A feed drive control method to improve the accuracy of periodic trajectory is described and evaluated. The method is based on the combination of feedforward control (zero phase error tracking control) and repetitive control. Adding the repetitive control compensates for the model mismatching which generally degrades feedforward control performance. Investigations on robust stability and disturbance effects reveal some tips on controller design. A repetitive controller is proposed to assure robust stability for unmodelled dynamics and dead-time while maintaining tracking performance in low frequencies. The regulation error, however, is increased in certain frequencies by adding the repetitive controller under the existence of load disturbances and measurement noise. Simulation results indicate that the proposed approach greatly decreases the tracking error.