gebhart/patrepeval huggingface dataset:
Can cholesterol metabolism and prostate function be relevant co-factors in Can f 5-related human seminal plasma allergy? (2022)

Human seminal plasma allergy (HSPA) is a rare condition referred as hypersensitization to the non-spermatozoa part of semen. The mechanism involved is usually IgE-mediated. Clinical presentation is often non-specific and age of onset it’s widely variable. Can f 5 is a recently discovered major allergen for respiratory sensitization resulted to be a prostatic kallikrein that cross-reacts with prostatic specific antigen (PSA). Risk factors have been hypothesized based on single case reports. In the case we are reporting the only known lifestyle or clinical modification other than the adoption of a male dog was the patient’s partner taking ezetimibe for hypercholesterolemia. The symptoms disappeared when the partner introduced a statin in combination with ezetimibe. Therapy with ezetimibe was not suspended and so it was not demonstrated that the drug assumption was related with the symptoms. In one case in literature symptoms have been reported after the woman’s partner underwent a partial prostatectomy. One of the factors that elicited our clinical case may be correlated to cholesterol metabolism and prostate function; lipid disorders and prostatic hyperplasia being very common their correlation is still not completely understood.
Quantitative Ultrasonic Tissue Characterization Can Identify High-Risk Atherosclerotic Alteration in Human Carotid Arteries (2000)

In conjunction with conventional B-mode imaging, IBS analysis with carotid ultrasonography appeared to provide prognostic information to identify a high-risk group with systemic atherosclerosis, which could lead to coronary heart disease in individuals with early-stage disease.
A Study on Reduced/Absent Adhesion/Cap Layers for Optimized BEOL RC Performance (2019)

Abstract Lower RC delay is vital to achieve optimal and competitive circuit performance and hence drives the endlessly pursued BEOL integration scheme advancement. To date low-k dielectric materials, i.e., fluorine-doped oxides, carbon-doped oxide (SiCOH), to porous carbon-doped oxides (p-SiCOH) have been implemented. However, due to the process integration challenges with inherently weak low-k materials, the trend to pursue lower k dielectrics has come to a plateau as technology nodes scale down past 20/14nm. On the other hand, the trend of geometry layer thickness shrinking down, such as trench CD and height, via CD and height, etc., still continues for each advanced technology node. In the BEOL stack adhesion layers (oxide + gradient layers) (ALs) with higher k value were introduced to enhance interface adhesion strength between SiCOH/p-SiCOH and dielectric cap film (SiCN), which offset the intrinsic RC benefit from low-k dielectric material. At more advanced nodes and beyond, the combined ALs and cap film could be up to via or trench height, which poses a huge challenge to meet desired RC performance and technology node scaling. Therefore, the thickness reduction of ALs and cap film becomes necessary for further technology node scaling. In this study, samples with interfacial full ALs, reduced ALs and bulk only (no ALs) for p-SiCOH (k=2.75) on various cap films were prepared, such as SiCN, SiCN/ODC, SiCN/AlONx, etc. TOF-SIMS analyses was used to confirm the composition of the dielectric stacks and later check the debonded surface morphology. Four-point bend adhesion tests were conducted to evaluate interfacial adhesion strength. Results show the interfacial adhesion strength on samples with reduced Als and bulk only (no ALs) is dropped by ~20% and ~30%, respectively. Additional ODC layer on top of SiCN would increase the interfacial adhesion strength by ~10%. It is suggested that reduced ALs may be adequate to satisfy overall CPI requirement for the BEOL integration scheme of p-SiCOH on advanced dielectric cap films (AlN + ODC). The coupling capacitance reduction for a combined reduced ALs and advanced dielectric cap can be up to 16% at M0 level and 10% at Mx level for a 40nm metal pitch.
Mining predicted crystal structure landscapes with high throughput crystallisation: old molecules, new insights (2019)

Organic molecules tend to close pack to form dense structures when they are crystallised from organic solvents. Porous molecular crystals defy this rule: they contain open space, which is typically stabilised by inclusion of solvent in the interconnected pores during crystallisation. The design and discovery of such structures is often challenging and time consuming, in part because it is difficult to predict solvent effects on crystal form stability. Here, we combine crystal structure prediction (CSP) with a robotic crystallisation screen to accelerate the discovery of stable hydrogen-bonded frameworks. We exemplify this strategy by finding new phases of two well-studied molecules in a computationally targeted way. Specifically, we find a new 'hidden' porous polymorph of trimesic acid, δ-<b>TMA</b>, that has a guest-free hexagonal pore structure, as well as three new solvent-stabilized diamondoid frameworks of adamantane-1,3,5,7-tetracarboxylic acid (<b>ADTA</b>). Beyond porous solids, this hybrid computational-experimental approach could be applied to a wide range of materials problems, such as organic electronics and drug formulation.
Revisiting password rules: facilitating human management of passwords (2016)

Password rules were established in the context of past security concerns. Recent work in computer security challenges the conventional wisdom of expert password advice, such as change your passwords often, do not reuse your passwords, or do not write your passwords down. The effectiveness of these rules for protecting user accounts against real world attacks is questioned. We review the latest research examining password rules for general-purpose user authentication on the web, and discuss the arguments behind the continued acceptance or the rejection of the rules based on empirical evidence and solid justifications. Following the review, we recommend an updated set of password rules.
Data from Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Nicotinamide phosphoribosyltransferase (Nampt) regulates intracellular NAD&lt;sup&gt;+&lt;/sup&gt; pool and is highly expressed in a number of malignancies. FK866, a selective inhibitor of Nampt, depletes intracellular NAD&lt;sup&gt;+&lt;/sup&gt; levels, thereby blocking cellular metabolism and triggering sensitization to other drugs and cell death. Here we characterized the antitumor effects of Nampt inhibition in Waldenström macroglobulinemia.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We investigated Nampt role in MW cells using both mRNA and protein expression analyses. We have also used loss-of-function approaches to investigate the growth and survival effects of Nampt on MW cells and further tested the anti-MW activity of dual Nampt and BTK inhibition &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We found that Waldenström macroglobulinemia cells exhibit high levels of Nampt compared with normal B cells. Loss of function studies suggested a potential oncogenic role of Nampt in Waldenström macroglobulinemia cells, and BTK-inhibitor ibrutinib and FK866 resulted in a significant and synergistic anti-Waldenström macroglobulinemia cell death, regardless of MYD88 and CXCR4 mutational status. Cell death was associated with: (i) activation of caspase-3, PARP and downregulation of Mcl-1, (ii) enhanced intracellular ATP and NAD&lt;sup&gt;+&lt;/sup&gt; depletion, (iii) inhibition of NF-κB signaling, and (iv) inhibition of multiple prosurvival signaling pathways. In a murine xenograft Waldenström macroglobulinemia model, low-dose combination FK866 and ibrutinib is well tolerated, significantly inhibits tumor growth, and prolongs host survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our results show intracellular NAD&lt;sup&gt;+&lt;/sup&gt; level as crucial for proliferation and survival of Waldenström macroglobulinemia cells, and provides the mechanistic preclinical rationale for targeting Nampt, either alone or with Ibrutinib, to overcome drug resistance and improve patient outcome in Waldenström macroglobulinemia. &lt;i&gt;Clin Cancer Res; 22(24); 6099–109. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Surface-Only Spectroscopy for Diffusion-Limited Systems Using Ultra-Low Temperature DNP MAS NMR at 16.4 T (2020)

Conventional dynamic-nuclear-polarization (DNP) technique at T ~100 K can enhance sensitivity of magic-angle spinning (MAS) NMR over 100-fold for standard samples containing urea/proline at high-field conditions, B0= 9.4–16.4 T. In the scene of real applications, however, the achievable enhancement is often much lower than for urea/proline due to faster 1H relaxation (T1H) promoted by molecular-segmental fluctuations and methyl-group rotations active even at low temperatures, hindering an efficient polarization diffusion within the system. Here, we show at 16.4 T that ultra-low temperature (T≪100 K) provides a general way to improve the DNP efficiency for such diffusion-limited systems as we demonstrate on microcrystalline sample of a tripeptide N-f-MLF-OH. In a further step, the hyperpolarization localized at the crystal surface enabled “surface-only” spectroscopy eliminating background signals from the crystal core. The surface-only data, rather than the currently popular surface-enhanced data, should prove to be useful in many applications in biological and material sciences.
Immune evasion by CD200: New approaches to targeted therapies for chronic lymphocytic leukemia (CLL) (2006)

2519 Background: Although the human immune system is capable of raising an immune response against many cancer types, that response is insufficient to eradicate the cancer in most patients, possibly due to immune evasion through negative regulation of the immune system by the tumor. We identified the immune-suppressive molecule CD200 to be upregulated 1.5–5.4-fold on CLL cells in all 80 patients examined. Interaction of CD200 with its receptor alters cytokine profiles from Th1 to Th2 in mixed lymphocyte reactions, and results in the induction of regulatory T cells, which are thought to hamper tumor-specific effector T cell immunity. We addressed whether CD200 expression on tumor cells plays a role in immune evasion, thereby preventing elimination of tumor cells by the immune system in a xenograft hu/SCID mouse model, and whether treatment with an antagonistic anti-CD200 antibody affects tumor growth. Methods: The human non-Hodgkins lymphoma cell lines RAJI and Namalwa were transduced with human CD200 and injected subcutaneously together with human peripheral blood lymphocytes (PBL) into NOD/SCID mice. Tumor growth over time was compared among mice that either received CD200-expressing tumor cells or received tumor cells lacking CD200 expression. In subsequent experiments, mice were treated with chimeric or humanized anti-CD200 antibodies (doses ranged from 1 to 20 mg/kg) by intravenous injection. Treatment was either started immediately or 7 days after tumor cell injection. Results: As expected, PBLs reduced CD200-negative RAJI or Namalwa tumor growth by up to 75%. In contrast, growth of RAJI or Namalwa tumors expressing CD200 at levels comparable to that of CLL was not reduced by PBLs. Administration of anti-CD200 antibodies at 5 mg/kg resulted in nearly complete tumor growth inhibition (1/10 mice developed a small tumor) over the course of the study even when treatment was started 7 days after tumor cell injection. Conclusions: CD200 expression on tumor cells inhibits the ability of human lymphocytes to eradicate tumor cells. Treatment of CD200-expressing tumors with antagonistic anti-CD200 antibodies inhibits tumor growth, indicating the potential for anti-CD200 therapy as a promising approach for CLL. No significant financial relationships to disclose.
Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes (2017)

Multiwalled carbon nanotubes (MWCNTs) are nanomaterials composed of multiple layers of graphene cylinders with unique properties that make them valuable for a number of industries. However, rising global production has led to concerns regarding potential occupational exposures to them as raw materials during handling. This is especially true for long MWCNT fibers, whose aspect ratio has been posited to initiate pathology similar to that of asbestos. Matrix metalloproteinases (MMPs) are a class of extracellular endopeptidases that control various processes related to tissue repair, inflammation, and more. Stromelysin-2 (MMP-10) has roles in modulating macrophage activation and function, and hence, we used an MMP-10 null (<i>Mmp10</i><sup>-/-</sup>) mouse model to assess its role in controlling lung responses to inhaled long MWCNTs. Oropharyngeal aspiration of long MWCNTs (80 µg/mouse) by wild-type mice induced expression of <i>Mmp10</i> mRNA, which was accompanied by a robust inflammatory response characterized by elevated expression of <i>Tnfa</i>, <i>Il6</i>, and <i>Il1b</i>. In <i>Mmp10</i><sup>-/-</sup> mice, we found that absence of MMP-10 led to impaired pulmonary clearance of MWCNTs and reduced macrophage cell survival. Exposure of wild-type bone marrow-derived macrophages (BMDMs) and alveolar macrophages to MWCNTs caused a rapid, dose-dependent upregulation of <i>Mmp10</i> mRNA expression, which was accompanied by expression of pro-inflammatory products (<i>Il6</i> and <i>Il1b</i>). These products were further enhanced in <i>Mmp10</i><sup>-/-</sup> macrophages, resulting in increased caspase-3-dependent cell death compared with wild-type cells. These findings indicate that MMP-10 facilitates the clearance of MWCNTs and moderates the pro-inflammatory response of exposed alveolar and infiltrated macrophages.
Early onset Alzheimer's disease in a South American pedigree from Argentina (1995)

We report the clinical, SPET, immunohistochemical and DNA features of an early-onset familial Alzheimer's disease (FAD) in an Argentine pedigree of South American indian ethnic background. Pedigree spans 5 generations comprising more than 110 biological relatives. Clinical data supported the diagnosis of early onset FAD (mean age at onset 38.9 years) in 10 family members, including 3 with pathological confirmation (mean age at death 48.5). The pattern of transmission suggested autosomal dominant inheritance. Prominent features were mood changes, early language impairment, myoclonus, seizures and cerebellar signs. SPET displayed bilateral frontal, temporo-parietal and cerebellar hypoperfusion in early stages and in an asymptomatic member at risk, suggesting that SPET may have predictive value in this family. Immunohistochemistry showed beta amyloid deposits within neuritic plaques and vessel walls and no anti-PrP immunoreactivity. DNA analysis showed no abnormalities in the beta amyloid precursor protein gene. The identification of additional genetic defects in well characterized independent FAD pedigrees will contribute to the understanding of the pathogenesis of Alzheimer's disease.
Single Scattering Albedo Monitor for Airborne Particulates (2015)

We describe a robust, compact, field deployable instrument (the CAPS PMssa) that simultaneously measures airborne particle light extinction and scattering coefficients and thus the single scattering albedo (SSA) on the same sample volume. With an appropriate change in mirrors and light source, measurements have been made at wavelengths ranging from 450 to 780 nm. The extinction measurement is based on cavity attenuated phase shift (CAPS) techniques as employed in the CAPS PMex particle extinction monitor; scattering is measured using integrating nephelometry by incorporating a Lambertian integrating sphere within the sample cell. The scattering measurement is calibrated using the extinction measurement. Measurements using ammonium sulfate particles of various sizes indicate that the response of the scattering channel with respect to measured extinction is linear to within 1% up to 1000 Mm−1 and can be extended further (4000 Mm−1) with additional corrections. The precision in both measurement channels is less than 1 Mm−1 (1s, 1σ). The truncation effect in the scattering channel, caused by light lost at extreme forward/backward scattering angles, was measured as a function of particle size using monodisperse polystyrene latex particles (n = 1.59). The results were successfully fit using a simple geometric model allowing for reasonable extrapolation to a given wavelength, particle index of refraction, and particle size distribution, assuming spherical particles. For sub-micron sized particles, the truncation corrections are comparable to those reported for commercial nephelometers. Measurements of the optical properties of ambient aerosol indicate that the values of the SSA of these particles measured with this instrument (0.91 ± 0.03) using scattering and extinction agreed within experimental uncertainty with those determined using extinction measured by this instrument and absorption measured using a multi-angle absorption photometer (0.89 ± 0.03) where the uncertainties are derived from best estimates of the accuracy of the two approaches.Copyright 2015 American Association for Aerosol Research
Time Resolved FRET Strategy with Fluorescent Ligands to Analyze Receptor Interactions in Native Tissues: Application to GPCR Oligomerization (2011)

G protein-coupled receptors (GPCRs) play a key role in the regulation of physiological functions. Deregulation of their activities often results in pathological disorders and therefore these receptors constitute major targets for drug development. The emergence of new concepts such as GPCR oligomerization has modified our understanding of these proteins, and identifying the role of receptor complexes is probably a major challenge for the next decade. Various experimental strategies have been developed to study GPCR oligomers and energy transfer experiments between partners within a complex constitute one of the most convenient approaches. These experimental strategies usually require receptor fusion to tags or fluorescent or luminescent proteins and therefore cannot be easily applied to native tissues. We developed a new experimental approach based on the labeling of receptors with high affinity fluorescent ligands compatible with time-resolved energy transfer measurements. Because of the very high signal-to-noise ratio of the time-resolved fluorescent energy transfer (TR-FRET) signals, this approach constitutes a breakthrough since it allows the direct identification of wild-type GPCR oligomers in native tissues.
Evaluating active learning for blind imbalanced domains (2023)

Deep learning, which has been very successful in recent years, requires a large amount of data. Active learning has been widely studied and used for decades to reduce annotation costs and now attracts lots of attention in deep learning. Many real-world deep learning applications use active learning to select the informative data to be annotated. In this paper, we first investigate laboratory settings for active learning. We show significant gaps between the results from different laboratory settings and describe our practical laboratory setting that reasonably reflects the active learning use cases in real-world applications. Then, we introduce a problem setting of blind imbalanced domains. Any data set includes multiple domains, e.g., individuals in handwritten character recognition with different social attributes. Major domains have many samples, and minor domains have few samples in the training set. However, we must accurately infer both major and minor domains in the test phase. We experimentally compare different methods of active learning for blind imbalanced domains in our practical laboratory setting. We show that a simple active learning method using softmax margin and a model training method using distance-based sampling with center loss, both working in the deep feature space, perform well.
Retinoic acid enhances sensitivity of neuroblastoma cells for imatinib mesylate (2010)

The combination of retinoids with kinase inhibitors might be worth exploring further for the treatment of NB patients.
Evaporative intrachip hotspot cooling with a hierarchical manifold microchannel heat sink array (2016)

A hierarchical manifold microchannel heat sink is used to dissipate heat from a small hotspot region superposed on a larger region of uniform background heat flux. A 5 mm × 5 mm overall chip footprint area is cooled using a 3 × 3 array of intrachip silicon microchannel heat sinks fed in parallel using a manifold distributor. Each heat sink consists of a bank of 25 high-aspect-ratio microchannels that are nominally 30 μm wide and 300 μm deep. The uniform background heat flux is generated with a 3 × 3 array of thin-film heaters fabricated on the chip; temperature sensors placed in each of these nine heating zones provide spatially resolved chip surface temperature measurements. An individually powered 200 μm × 200 μm hotspot heater is centered on the chip. The heat sink thermal and hydraulic performance is evaluated using HFE-7100 as the working fluid and for mass fluxes ranging from 600 kg/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> s to 2070 kg/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> s at a constant inlet temperature of 60°C and outlet pressure of 122 kPa. Background heat fluxes up to 450 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and hotspot fluxes of greater than 2500 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> are simultaneously dissipated. The chip temperature uniformity and maximum temperature rise during hotspot heating are assessed. For the case with the highest simultaneous background and hotspot heat fluxes, the measured heat sink pressure drop is ~75 kPa and the average chip temperature is ~30°C above the fluid inlet temperature.
(Invited) Fabrication of Ordered Metal Nanostructures for Plasmonic Devices Using Anodic Porous Alumina (2013)

Abstract not Available.
The band alignment of Cu2O/ZnO and Cu2O/GaN heterostructures (2012)

Using photoelectron spectroscopy, we investigate the band alignments of the Cu2O/ZnO heterointerface and compare the findings with the corresponding values for Cu2O/GaN. While for Cu2O/ZnO, we find a valence band offset (VBO) of 2.17 eV and a conduction band offset (CBO) of 0.97 eV, both values are considerably reduced for Cu2O/GaN where the numbers are 1.47 eV (VBO) and 0.24 eV (CBO), respectively. The large CBO between ZnO and Cu2O will very likely result in low photovoltaic power conversion efficiencies as is the current status of Cu2O/ZnO solar cells.
Sodium glucose co-transporter 2 (SGLT2) inhibitors: novel antidiabetic agents (2012)

SGLT2 inhibitors offer a new fundamentally different approach for treatment of diabetes. To date, the clinical results suggest that for non-renally impaired patients this class of inhibitors could be safely used at any stage of T2DM either alone or in combination with other marketed antidiabetic medications.
Simulation, Fabrication and Characterization of 4H-SiC Floating Junction Schottky Barrier Diodes (Super-SBDs) (2007)

The calculation for 4H-SiC floating junction Schottky barrier diodes (Super-SBDs) was carried out by device simulation and the optimized device structure was fabricated. The best characteristics of the Super-SBDs were breakdown voltage of 2700V and the specific on-resistance of 2.57m*cm2. The world record of Bariga’s Figure of Merit (BFOM) for SiC-SBD expressed by 4Vbd 2/Ron was improved to 11,354MW/cm2.