gebhart/patrepeval huggingface dataset:
COMPARISON OF DAY AND NIGHT IMAGERY IN SUPPORT OF THE NORMALIZED DIFFERENCE THERMAL INDEX (NDTI) 1 (2009)

This paper expands on the authors’ previous research in the development of a Normalized Difference Thermal Index (NDTI) to distinguish pavements from roofs as part of a remote sensing application. In the previous study, a single daytime data set from the multispectral Advanced Thermal and Land Applications Sensor (ATLAS) system was used to differentiate between urban pavements and roofs on the basis of differences in their thermal infrared (TIR) signatures. In this study, a daytime TIR data set was compared with a nighttime data set of the same geographic area, collected within a 2 day period, to determine whether differences in material heating and cooling rates could help to produce more accurate imagery than by using a single data set alone. Statistical analyses of the data sets supports the viability of the NDTI as a TIR imaging technique for urban infrastructure.
Origins of the Journal of the Catholic Psychotherapy Association: Integratus (2023)

A MISSION WITHIN A MISSION As the inaugural issue of Integratus: The Journal of the Catholic Psychotherapy Association is published, we celebrate the actualization of one of the dreams of the founding members of our organization. The Catholic Psychotherapy Association (CPA) grew out of a small group of professionals in the Atlanta, Georgia, area who began meeting to support each other in the ethical integration of the Catholic faith in clinical practice. This original group gained recognition as a Catholic organization by Archbishop John Francis Donohue in 2002. Upon joining together with others across the United States, the first meeting of the professional organization that we now know as the CPA occurred in 2007. At that time, the eventual publication of a scholarly journal was high on the list of dreams of how the organization may one day bloom. To our knowledge, Integratus is the first journal to integrate Catholic theology and anthropology with the mental health sciences and fills a gap in the respective spheres of professional and theological scholarship.
Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ (2011)

Cancer cells exhibit the ability to proliferate indefinitely, but paradoxically, overexpression of cellular oncogenes in primary cells can result in a rapid and irreversible cell cycle arrest known as oncogene-induced senescence (OIS). However, we have shown that constitutive overexpression of the oncogene c-MYC in primary human foreskin fibroblasts results in a population of cells with unlimited lifespan; these immortalized cells are henceforth referred to as iMYC. Here, in order to further elucidate the mechanisms underlying the immortalization process, a gene expression signature of three independently established iMYC cell lines compared to matched early passage c-MYC overexpressing cells was derived. Network analysis of this "iMYC signature" indicated that a large fraction of the down-regulated genes were functionally connected and major nodes centered around the TGFβ, IL-6 and IGF-1 signaling pathways. Here, we focused on the functional validation of the alteration of TGFβ response during c-MYC-mediated immortalization. The results demonstrate loss of sensitivity of iMYC cells to activation of TGFβ signaling upon ligand addition. Furthermore, we show that aberrant regulation of the p27 tumor suppressor protein in iMYC cells is a key event that contributes to loss of response to TGFβ. These findings highlight the potential to reveal key pathways contributing to the self-renewal of cancer cells through functional mining of the unique gene expression signature of cells immortalized by c-MYC.
Effects of Moisture and Redox Reactions in VCM and ECM Resistive Switching Memories (2016)

Redox-based memristive devices (ReRAM) have been intensively studied in recent years with respect to their functions as applications in non-volatile memories, selector devices and building units for beyond von Neumann computing. Despite the fact that many details regarding the switching mechanism have been reported and that significant improvements in the device performance have been achieved, the large variability remains a serious disturbing factor. One of the sources of this variability was shown to be moisture. It can be absorbed from the local environment or during device fabrication. The role of the water molecules is multifold—a source for a counter electrode reaction, they provide additional charges in the oxide matrix, i.e. protons or oxygen, they enhance the ion diffusion and act as a corrosive agent.In this review, we discuss how moisture is incorporated in oxides and its impact on the ReRAM device operation. We show that it affects not only the electrochemical redox characteristics, but that it also increases the conductivity of the material and modulates the switching kinetics. The particular influence of H2O for both electrochemical metallization memories (ECM) and valence change memories (VCM) is exemplarily demonstrated and discussed. The importance of controlled moisture content as a component in the ReRAM devices as a memory and neuromorphic units is highlighted.
Treatment of polyethylene and polypropylene with chlorosulphonic acid to study the surface morphology (1992)

Samples of low- and high-density polyethylene (PE) and polypropylene (PP) have been treated with chlorosulphonic acid at room temperature for various periods of time. Optical microscopy showed that the chlorosulphonic acid penetration rate was constant with time in bulk low-density PE. The treated polymers became black, and the chlorosulphonic acid penetration depth was also determined on the basis of a colour (blackness) scale. The blackness scale allowed the determination of chlorosulphonic acid penetration depth values smaller than 14μm. Mild surface oxidation of low-density PE caused a significant increase in the initial chlorosulphonic acid penetration rate. A method for estimating the thickness of the oxidized surface layer is presented in this paper. The chlorosulphonic acid penetration rate was also found to decrease markedly with increasing crystallinity of PE. Chlorosulphonic acid treatment of PP led to digestion of the polymer without any appreciable formation of a black surface layer.
Direct N9-arylation of purines with aryl halides (2014)

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.
Porous Molecular Solids (2014)

Organic molecules have been discovered, which can be utilized as synthetically prefabricated molecular pore templates for the construction of self-assembled porous molecular materials. They have shown permanent porosity to gas molecules or selective guest binding in either crystalline or amorphous solid state. The porosity of these materials is a result of both of the intrinsic molecular voids and extrinsic voids from the inefficient packing. Moreover, the packing motifs can be directed by the functionality of molecules, giving control over the pore connectivity. Pore molecular solids are of interest for a wide range of applications in gas storage, separation, and molecular recognition. Herein, we describe a series of porous organic molecules in terms of both synthetic and computational approaches. Molecular simulations offer a unique perspective by allowing the examination of the structures on the molecular level, and also give additional insight into understanding the nature of these materials and assist in the design and tailoring for specific applications.
Tata Center for Technology and Design at MIT (2020)

His research focuses on the marriage of mechanical design theory and usercentered product design to create simple, elegant technological solutions for use in highly constrained environments.His work includes design for emerging markets and developing countries, biomimetic design, fluid/solid/granular mechanics, biomechanics, and the design of ocean systems.Prof. Winter is the principal inventor of the Leveraged Freedom Chair (LFC), an all-terrain wheelchair designed for developing countries that was a winner of a 2010 R&D 100 award and was named one of the Wall Street Journal's top innovations in 2011.His Ph.D. work focused on adapting the burrowing mechanisms of razor clams to create compact, low power, and reversible burrowing systems for subsea applications such as anchoring, oil recovery, and cable installation.Prof.
Green Communication: Where Can It Really Help and How It Is Related to RFID (2009)

In the recent years, the awareness about the harmful long-term effects of the greenhouse gases (GHG) has markedly increased. As information and communication technologies (ICT) have successfully and irreversibly pervaded everyday life, many technology leaders have started to look into the green ICT, i. e. ICT solutions that have reduced carbon emissions. A sobering report from WWF has indicated that only 2 % of the carbon emissions can be attributed to the ICT systems. Therefore, the real green impact of ICT can be made by using ICT to make the other systems more energy-efficient, such as the buildings, transportation, power grid, industry and production. In this paper we argue that the RFID technology can be one of the key drivers for implementing green ICT solutions in the systems that are not originally associated with ICT, e. g. transportation. In particular, the passive, battery-less RFID systems have potential to map the physical world to the virtual one and drive actions back from the virtual to the physical world with positive carbon balance, i. e. the carbon emissions saved by those actions are larger than the carbon emissions caused to operate the RFID systems. Motivated by that observation, we list several example green applications of the RFID systems.
The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment (2005)

MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
Fabrication of polymer antireflection structures by injection molding using ordered anodic porous alumina mold (2014)

Polymer antireflection structures were fabricated by injection molding using anodic porous alumina or a Ni replica as a mold. An ordered array of tapered pillars or holes was successfully formed on the surface of polycarbonate plates. The obtained polymer antireflection structures exhibit a lower reflectance than a smooth polycarbonate surface.
Unsupervised environment recognition and modeling using sound sensing (2013)

We discuss the problem of automatically discovering different acoustic regions in the world, and then labeling the trajectory of a robot using these region labels. We use quantized Mel Frequency Cepstral Coefficients (MFCC) as low level features, and a temporally smoothed variant of Latent Dirichlet Allocation (LDA) to compute both the region models, and most likely region labels associated with each time step in the robot's trajectory. We validate our technique by showing results from two datasets containing sound recorded from 51 and 43 minute long trajectories through downtown Montreal and the McGill University campus. Our preliminary experiments indicate that the regions discovered by the proposed technique correlate well with ground truth, labeled by a human expert.
Designing a Low Activation Pressure Drip Irrigation Emitter With Constraints for Mass Manufacturing (2016)

This work discusses the modeling and optimization of a drip irrigation emitter for reducing activation pressure. Our model formulation focuses on analytically characterizing fluid-structure interactions in an existing 8 liters per hour (lph) pressure-compensating online emitter. A preliminary experimental validation of the resulting model was performed for three different emitter architectures. This model was used as a basis for a genetic algorithm-based optimization algorithm that focused on minimizing activation pressure. The design variables considered in our formulation include, geometric features of the emitter architecture, and practical constraints from manufacturing. We applied our optimization approach to four emitters (with flow rates of 4, 6, 7 and 8.2 lph) and were able to lower activation pressure by more than half in each case. The optimization results for all four emitters were experimentally validated in lab-studies. We performed a more exhaustive validation study for the 8.2 lph emitter with an emitter manufacturer. Results from these experiments (which followed ISO standards) showed that the optimized 8.2 lph emitter had a 75% lower activation pressure when compared to the original emitter design.
Tremor varies as a function of the temporal regularity of deep brain stimulation (2008)

The frequency of stimulation is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal pattern of stimulation. We conducted intraoperative measurements of the effect of temporally irregular DBS (nonconstant interpulse intervals) on tremor. As the coefficient of variation of irregular high frequency DBS trains increased, they became less effective at reducing tremor (mixed effects regression model, P<0.04). These data provide evidence that the effects of DBS are dependent not only on the average frequency of DBS, but also on the regularity of the temporal spacing of DBS pulses.
Continuous Dyeing of Piece Goods Using Radio‐frequency Heating. Part 2‐Migration Induced During Dyeing (1986)

Reactive dyes on open‐width cotton fabric migrate during drying using r.f energy. This migration, contrary to expectations, is greater than that obtained when using conventional hot‐air drying. The extent of dye migration is reduced by an increase in the electrolyte concentration of the dye pad liquor. A possible explanation for r.f.‐induced dye migration is proposed.
Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis (1998)

The AGTR1 allele C is associated with high activity of SACE in patients with sarcoidosis. It is another predisposing factor for high levels of SACE in patients with sarcoidosis and is considered to be an independent factor from the ACE D allele for high levels of SACE in sarcoidosis. This fact could be one of the explanations for the increased SACE activity in sarcoidosis.
C2A activates a cryptic Ca 2+ -triggered membrane penetration activity within the C2B domain of synaptotagmin I (2002)

Synaptotagmin (syt) I, an integral membrane protein localized to secretory vesicles, is a putative Ca(2+) sensor for exocytosis. Its N terminus spans the membrane once, and its cytoplasmic domain contains two conserved C2 domains, designated C2A and C2B. The isolated C2A domain penetrates membranes in response to Ca(2+); isolated C2B does not. Here, we have addressed the function of each C2 domain, but in the context of the intact cytoplasmic domain (C2A-C2B), by using fluorescent reporters placed in the Ca(2+)-binding loops of either C2A or C2B. Surprisingly, these reporters revealed that, analogous to C2A, a Ca(2+)-binding loop in C2B directly penetrates into lipid bilayers. Penetration of each C2 domain was very rapid (k(on) approximately 10(10) M(-1) x s(-1)) and resulted in high affinity C2A-C2B-liposome complexes (K(d) approximately 13-14 nM). C2B-bilayer penetration strictly depended on the presence, but not the membrane binding activity, of an adjacent C2A domain, severing C2A from C2B after protein synthesis abolished the ability of C2B to dip into bilayers in response to Ca(2+). The activation of C2B by C2A was also displayed by the C2 domains of syt III but not the C2 domains of syt IV. A number of proteins contain more than one C2 domain; the findings reported here suggest these domains may harbor cryptic activities that are not detected when they are studied in isolation.
Critical issues in 157 nm lithography (1998)

Projection lithography at 157 nm is a candidate technology for the 100–70 nm generations, and possibly beyond. It would provide an evolutionary extension to the current primary photolithographic processes and components: excimer lasers, refractive optics, and transmissive masks. This article presents data on the transmission of optical materials at 157 nm, the performance of optical coatings, the issues that must be faced by photomasks, and the considerations related to engineering resists at this wavelength.
1H and 15N assignments and secondary structure of the PI3K SH3 domain (1993)

The sequential 1 H and 15 N assignments of the SH3 domain of human phosphatidyl inositol 3'‐kinase (PI3K) were determined by a combination of homonuclear and heteronuclear NMR experiments. With the exception of several protons belonging to lysine and proline residues, all proton and proton‐bearing amide nitrogen resonances were assigned. Based on the sequential nuclear Overhauser effects (NOEs), 3 J NH‐CαH coupling constants and locations of slowly exchanging amide protons, we determined that the secondary structures of the protein consists of six β‐strands, two β‐turns and four short helices. Additional long range NOEs indicate that these β‐strands form two antiparallel β‐sheets. The topology of secondary structural elements of the PI3K SH3 domain is similar to those of the SH3 domains from c‐Src and α‐spectrin, suggesting that the SH3 family has a common tertiary structural motif.
Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration (2023)

Remote and precisely controlled activation of the brain is a fundamental challenge in the development of brain-machine interfaces for neurological treatments. Low-frequency ultrasound stimulation can be used to modulate neuronal activity deep in the brain, especially after expressing ultrasound-sensitive proteins. But so far, no study has described an ultrasound-mediated activation strategy whose spatiotemporal resolution and acoustic intensity are compatible with the mandatory needs of brain-machine interfaces, particularly for visual restoration. Here we combined the expression of large-conductance mechanosensitive ion channels with uncustomary high-frequency ultrasonic stimulation to activate retinal or cortical neurons over millisecond durations at a spatiotemporal resolution and acoustic energy deposit compatible with vision restoration. The in vivo sonogenetic activation of the visual cortex generated a behaviour associated with light perception. Our findings demonstrate that sonogenetics can deliver millisecond pattern presentations via an approach less invasive than current brain-machine interfaces for visual restoration.
Probing the functions of NAAG via NAAG peptidases and MGLUR3 (2002)

We have characterized N‐acetylaspartylglutamate (NAAG) and found that the peptide inhibits transmitter release by activation of mGluR3 receptors at presynaptic endings. To learn more about the synaptic activity of NAAG, we have synthesized a series of novel compounds that are potent inhibitors of brain NAAG peptidase activity as well as the activity of cloned human and rat glutamate carboxypeptidase II (GCPII), an enzyme that was believed to be solely responsible for inactivation of NAAG following synaptic release. We tested two of these compounds in models of chronic and neuropathic pain and found them to be antinociceptive. We have produced and characterized a strain of GCPII knock‐out mice and discovered a residual NAAG peptidase activity in their brains and spinal cords. They appear quite similar to their wild type littermates in terms of growth, reproduction, basic neurological features, acute pain threshold, rotor rod and open field behavior, and NAAG, glutamate, and mGluR3 mRNA levels. These data support the hypothesis that one or more uncharacterized enzymes may be involved in the inactivation of NAAG. We have found several differences between the NAAG peptidase activity found in the knock‐out vs. wild type brain membranes, including differential sensitivity to the peptidase inhibitor 2‐PMPA. The cloning of an additional gene(s) coding for nervous system NAAG peptidase and the development of selective inhibitors of NAAG peptidase activity have the potential to contribute to understanding the role of NAAG in excitotoxicity and chronic pain perception.
Characterization of Fe-doped In-Sb-Te (Fe: 10 at.%) material with individual electrical-phase-change and magnetic properties (2011)

We propose a new electrical-phase-change magnetic material, namely Fe-doped In-Sb-Te (FIST), for possible non-volatile multi-bit memory applications. FIST was formed by typical co-sputter method with Fe 10 at.% doping in In3Sb1Te2. FIST offers the electrical-phase-change and magnetic properties by way of the change of In 4d chemical bonding density and embedded Fe nanoclusters with the size of 4∼5 nm, respectively. It maintained the amorphous phase on the electrical-phase-change. Chemical state of In was only changed to increase the density of In-In chemical bonding during the electrical-phase-change without Fe nanoclusters contribution. Also, the magnetic property by Fe nanoclusters was not changed by the electrical-phase-change. On this basis, we propose the FIST material with the individual electrical-phase-change and magnetic properties for the multi-bit nonvolatile memory materials.
DDQ Oxidation of Ring-A Methoxylated 11b-Methoxycarbonyl-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino[8,7-b]indoles (1991)

A study of the oxidation of ring-A methoxylated 11b-methoxycarbonyl-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino[8,7-b]indoles (8a-8e) with DDQ in aqueous tetrahydrofuran was carried out. Treatment of 8a-8c under these conditions effected regiospecific oxidation at C-6 in yields ranging from 40-76% to provide the corresponding ring-A methoxylated 3,6-dioxo-1H-indolizino[8,7-b]indoles (12a-12c), respectively. The oxidation of the 7,8,9-trimethoxy analog (8d) also gave the 6-oxo derivative (12d), albeit in low yield. In contrast, the reaction of 8,10-dimethoxyindolizino[8,7-b]indole (8e) with DDQ (aq. THF) generated the quinone (12e), the structure of which is reminescent of the mitomycins. A proposed pathway for the origin of quinone (12e) is presented
Benefits of Using Decorrelated Color Information for Face Segmentation/Tracking (2008)

We analyze in this paper the benefits that can be derived from employing color image alignment techniques in the context of face segmentation or tracking based on texture (defined as the patch of intensities) template matching. By making full use of the decorrelated color information, improvements on the accuracy of the segmentation are demonstrated. This is intended to enhance the face segmentation algorithm by increasing its robustness to differences in images caused by various image acquisition devices or settings or by variations in the ambient illumination conditions.