gebhart/patrepeval huggingface dataset:
Mechanical properties of nickel ion-implanted with titanium and carbon and their relation to microstructure (1998)

Dual ion implantation of titanium and carbon into nickel was shown to produce an amorphous layer with exceptionally high strength and hardness and substantially improved tribological properties. Indentation testing at submicrometer penetrations combined with finite-element modeling permitted quantification of the intrinsic elastic and plastic properties of the amorphous layer, which was found to have a yield strength near 5 GPa. During unlubricated sliding contact with a steel pin, the implantation treatment reduced friction, suppressed adhesion-and-fracture wear, and reduced wear depth. These tribological effects may enhance the performance and lifetime of microelectromechanical systems constructed from nickel.
Preparation of epitaxial Pb(ZrxTi1−x)O3 thin films and their crystallographic, pyroelectric, and ferroelectric properties (1989)

Lead zirconate-titanate (PZT) thin films with tetragonal and rhombohedral structures have been successfully grown with good epitaxy on MgO single crystals and on [100]-oriented platinum thin films by rf-magnetron sputtering. The PZT films were obtained by using sputtering targets with compositions of Pb(ZrxTi1−x)O3, where x=0.2–0.8. The tetragonal PZT thin films have a strong [001] orientation, and the rhombohedral ones are (100) oriented. Asymmetric D-E hysteresis loops were observed on the tetragonal films. Nearly symmetric loops were observed on the rhombohedral films and the rhombohedral loops around the morphotropic phase boundary had slim loops. The tetragonal thin films of x=0.45 have a spontaneous polarization of 45 μC/cm2, a remanent polarization of 40 μC/cm2, and a coercive field of 150 kV/cm. It was found that significant pyroelectric currents are detected on both [001]-oriented tetragonal and (100)-oriented rhombohedral PZT films even without a poling treatment, and the direction is the same in all specimens. The relative dielectric constant εr achieves a maximum at the morphotropic phase boundary, as occurs for PZT ceramics. The pyroelectric coefficient γ increases with increase of Zr content and reaches a peak near the phase boundary in the tetragonal thin films. On the other hand, for the rhombohedral films, γ drops around the phase boundary and increases upon increasing Zr content. Thin films of x=0.45 have εr of 400 and γ of 4.2×10−8 (C/cm2 K). These films will be suitable for use in piezoelectric transducers and pyroelectric infrared detectors.
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases (2016)

Liver diseases are the fourth leading cause of mortality among adults in the United States. Patients with chronic liver diseases such as viral hepatitis, fibrosis, and cirrhosis have significantly higher risks of developing hepatocellular carcinoma (HCC). With a dismal five-year survival rate of 11%, HCC is the third most common cause of cancer-related deaths worldwide. Regardless of the underlying cause, late presentation and a lack of effective therapy are the major impediments for successful treatment of HCC. Therefore, there is a considerable interest in developing new strategies for the prevention and treatment of chronic liver diseases at the early stages. Cancer stem cells (CSCs), a small cell subpopulation in a tumor, exhibit unlimited self-renewal and differentiation capacity. These cells are believed to play pivotal roles in the initiation, growth, metastasis, and drug-resistance of tumors. In this review, we will briefly discuss pivotal roles of the CSC marker doublecortin-like kinase 1 (DCLK1) in hepatic tumorigenesis. Recent evidence suggests that anti-DCLK1 strategies hold promising clinical potential for the treatment of cancers of the liver, pancreas, and colon.
New and improved dispersion and recovery techniques for slurry phase catalysis. Quarterly report, January-March, 1984 (1984)

A mathematical model has been developed for predicting the effects of various parameters such as recycle rate, permanent and temporary deactivation rate constants on catalyst activity. The intent of this analysis is to evaluate the importance of the ease with which a catalyst can be regenerated and to identify important catalyst properties associated with regeneration. A reactor (hydrotreater)-regenerator system having equal catalyst inventory in each unit is used as a basis for modeling. A fixed amount of fresh catalyst supply and spent catalyst withdrawal are assumed to be applicable to the reactor. The analysis shows that a small percent increase in the permanent deactivation rate constant relative to total deactivation rate constant decreases the mean activity of the catalyst in the reactor significantly. In most cases, the mean activity of the catalyst increased with increasing recycle rate. The effect of regeneration rate constant on the catalyst activity was not significant compared to that of permanent deactivation rate constant. 13 references, 3 figures.
The Clinical, Biochemical, and Familial Presentation of Type V Hyperlipoproteinemia in Childhood (1977)

Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8-year-old sister all had endogenous hypertriglyceridemia (type IV hyperlipoproteinemia). In kindred A, an 11-year-old boy had triglyceride levels as high as 1,100 mg/100 ml and recurrent abdominal pain. His father had type V hyperlipoproteinemia; his mother was normal. All three of his older teenage siblings had type IV hyperlipoproteinemia. The enzymatic activities of lipoprotein lipase (LPL), hepatic triglyceride lipase (HTL), and histaminase (H) were studied in postheparin plasma. The LPL level was low in the children and both parents in kindred N. LPL level in kindred A was normal, except for one child with type IV hyperlipoproteinemia. HTL level was normal to above normal in both kindreds. Most patients had a normal H level, but one parent (kindred N) had no preheparin H and very low levels of postheparin H. There was a strong correlation (r = 0.58, significant at less than 1% level) between release of LPL and H but not between HTL and H (r= 0.22). The mean (+/- 1 S.D.) levels of the enzymes were as follows: LPL, 2.8 +/- 0.7 micronmol/ml/hr in kindred N and 5.4 +/- 2.2 micronmol/ml/hr in kindred A; H, 13.4 +/- 6.8 units/ml in kindred N and 22.0 +/- 11.9 units/ml in kindred A; and HTL, 18.0 +/- 7.1 micronmol/ml/hr in kindred N and 14.9 +/- 6.3 micronmol/ml/hr in kindred A. The enzymatic activities of kindreds N and A were significantly different for LPL (P less than .001) and H (.025 less than P less than .05) but not for HTL. All but one child had at least one high insulin level, which was accompanied by hyperglycemia in two children. The hypertriglyceridemia in all but one child was ameliorated on therapeutic diets. These data suggest that the genetic basis of the hypertriglyceridemia in these two families is different and that hyperchylomicronemia in childhood is not confined to the rara type I hyperliporproteinemia.
Tuning the melting point and phase stability of rare-earth oxides to facilitate their crystal growth from the melt (2022)

Abstract The challenge of growing rare-earth (RE) sesquioxide crystals can be overcome by tailoring their structural stability and melting point via composition engineering. This work contributes to the advancement of the field of crystal growth of high-entropy oxides. A compound with only small REs (Lu,Y,Ho,Yb,Er) 2 O 3 maintains a cubic C-type structure upon cooling from the melt, as observed via in-situ high-temperature neutron diffraction on aerodynamically levitated samples. On the other hand, a compound with a mixture of small and large REs (Lu,Y,Ho,Nd,La) 2 O 3 crystallizes as a mixture of a primary C-type phase with an unstable secondary phase. Crystals of compositions (Lu,Y,Ho,Nd,La) 2 O 3 and (Lu,Y,Gd,Nd,La) 2 O 3 were grown by the micro-pulling-down (mPD) method with a single monoclinic B-type phase, while a powder of (Lu,Y,Ho,Yb,Er) 2 O 3 did not melt at the maximum operating temperature of an iridium-rhenium crucible. The minimization of the melting point of the two grown crystals is attributed to the mismatch in cation sizes. The electron probe microanalysis reveals that the general element segregation behavior in the crystals depends on the composition.
ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2 (2021)

SARS-CoV-2, the etiologic agent of COVID-19, uses ACE2 as a cell entry receptor. Soluble ACE2 has been shown to have neutralizing antiviral activity but has a short half-life and no active transport mechanism from the circulation into the alveolar spaces of the lung. To overcome this, we constructed an ACE2-human IgG1 fusion protein with mutations in the catalytic domain of ACE2. A mutation in the catalytic domain of ACE2, MDR504, significantly increased binding to SARS-CoV-2 spike protein, as well as to a spike variant, <i>in vitro</i> with more potent viral neutralization in plaque assays. Parental administration of the protein showed stable serum concentrations with excellent bioavailability in the epithelial lining fluid of the lung, and ameliorated lung SARS-CoV-2 infection <i>in vivo</i>. These data support that the MDR504 hACE2-Fc is an excellent candidate for treatment or prophylaxis of COVID-19 and potentially emerging variants.
Engineering circuits for temporal control (2009)

Signaling circuits in cells are capable of generating complex outputs in response to simple inputs. In this study, we explore coarse-grained design principles behind input duration filters and sequential activators, which may elucidate mechanisms behind T cell sensitivity and selectivity as well as temporal control in the cell cycle.
Nucleate boiling heat transfer coefficients of halogenated refrigerants up to critical heat fluxes (2009)

In this work, nucleate pool boiling heat transfer coefficients (HTCs) of five refrigerants of differing vapour pressures are measured on a horizontal, smooth copper surface of 9.53×9.53 mm. The tested refrigerants are R123, R152a, R134a, R22, and R32 and HTCs are taken from 10 kW/m 2 to the critical heat flux (CHF) of each refrigerant. Wall and fluid temperatures are measured directly by thermocouples located underneath the test surface and in the liquid pool, respectively. Test results show that nucleate pool boiling HTCs of halogenated refrigerants increase as the heat flux and vapour pressure increase. This typical trend is maintained even at high heat fluxes above 200 kW/m 2 . Zuber's prediction equation for CHF is quite accurate showing a maximum deviation of 21 per cent for all refrigerants tested. For all refrigerants, Stephan and Abdelsalam's well-known correlation underpredicted nucleate boiling HTC data up to the CHF with an average deviation of 21.3 per cent, while Cooper's correlation overpredicted the data with an average deviation of 14.2 per cent. On the other hand, Gorenflo's and Jung et al.'s correlations showed 5.8 and 6.4 per cent deviations, respectively, in the entire nucleate boiling range up to the CHF.
Concomitant K- and N-ras gene point mutations in clonal murine lymphoma. (1988)

We have surveyed a panel of induced murine lymphomas for c-ras gene mutations. The K-ras gene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-ras gene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role of ras activation in tumor progression.
Intracellular cargo delivery with polymer substrates and nanosecond pulsed laser (Conference Presentation) (2018)

One major barrier to advancing fundamental studies of biological cargoes for clinical use has been effective delivery into the cytoplasm. Available methods such as electroporation, viral techniques, and liposomal reagents come with respective strengths and weaknesses depending on the application needs. We present a laser-based cargo delivery platform that combines 11-ns laser pulses and structured flexible polymer substrates to create transient pores in the plasma membrane of cells. Cells are grown on the substrates, and pores are induced form on the cells in the regions excited with nanosecond laser pulses—thus, allowing treatment selectivity in a population. The medium surrounding the cell contains the delivery cargoes in solution, and cargoes diffuse into the cell before the transient pores are sealed. Polymer-based substrates are a promising material for laser-based delivery methods because they are low-cost, have flexible spatial movements, and have simple fabrication techniques. We deliver cargos of various sizes. We use fluorescence imaging and flow cytometry to quantify the delivery efficiency and viability in a reproducible manner. We obtain delivery efficiencies of up to 40% with viabilities of 60% for calcein green in adherent cells such as HeLa and Panc-1. We also deliver molecules of up to 40 kDas and siRNA. We use scanning electron microscopy to study cell adherence and substrate surface morphology. Our data shows that polymer-based substrates can deliver biological material directly into cells in a cost-effective manner.
Using synthetic activity to design ultra-potent antibody cocktails (2021)

Abstract Drugs which independently inhibit a shared target or pathway can have synthetic activities that result in multiplicative instead of merely additive potencies. This characteristic of drug combinations can be quantified by expressing the potency of the combination as if it were a single agent. We show that by optimizing this quantity we can prospectively design drug cocktails with apparent potencies that far exceed any of its individual components. We illustrate the power of this approach, which is based on statistical design of experiments to select optimal drug combinations, and response surface methodology to determine optimal drug ratios, by building a drug cocktail comprised of three antibodies for treating C. difficile infection that is almost 1000-fold more potent than the current, clinically approved antibody monotherapy. High synthetic activities do not require unusual drug interactions, and therefore may be achievable much more readily than generally appreciated. One-Sentence Summary A development pathway is described for designing antibody cocktails with potencies that far exceed what is achievable with single antibodies
Effects of Carbohydrate Supplementation during Intense training on Dietary Patterns, Psychological Status, and Performance (1995)

The purpose of this study was to determine the effects of carbohydrate supplementation during intense training on dietary patterns, psychological status, and markers of anaerobic and aerobic performance. Seven members of the U.S. National Field Hockey Team were matched to 7 team counterparts (N = 14). One group was blindly administered a carbohydrate drink containing 1 g.kg-1 of carbohydrate four times daily, while the remaining group blindly ingested a flavored placebo during 7 days of intense training. Subjects underwent pre- and posttraining aerobic and anaerobic assessments, recorded daily diet intake, and were administered the Profile of Mood States (POMS) psychological inventory prior to and following each practice. Results revealed that the carbohydrate-supplemented group had a greater (p < .05) total energy intake, carbohydrate intake, and change (pre vs. post) in time to maximal exhaustion following training while reporting less postpractice psychological fatigue. However, no significant differences were observed in remaining psychological, physiological, or performance-related variables.
Supplementary Figure from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis (2023)

Supplementary Figure from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Communications and Signals Design for Wireless Power Transmission (2017)

Radiative wireless power transfer (WPT) is a promising technology to provide cost-effective and real-time power supplies to wireless devices. Although radiative WPT shares many similar characteristics with the extensively studied wireless information transfer or communication, they also differ significantly in terms of design objectives, transmitter/receiver architectures and hardware constraints, and so on. In this paper, we first give an overview on the various WPT technologies, the historical development of the radiative WPT technology and the main challenges in designing contemporary radiative WPT systems. Then, we focus on the state-of-the-art communication and signal processing techniques that can be applied to tackle these challenges. Topics discussed include energy harvester modeling, energy beamforming for WPT, channel acquisition, power region characterization in multi-user WPT, waveform design with linear and non-linear energy receiver model, safety and health issues of WPT, massive multiple-input multiple-output and millimeter wave enabled WPT, wireless charging control, and wireless power and communication systems co-design. We also point out directions that are promising for future research.
A comprehensive model-assisted brain shift correction approach in image-guided neurosurgery: a case study in brain swelling and subsequent sag after craniotomy (2019)

Brain shift during neurosurgery can compromise the fidelity of image guidance and potentially lead to surgical error. We have developed a finite element model-based brain shift compensation strategy to correct preoperative images for improved intraoperative navigation. This workflow-friendly approach precomputes potential intraoperative deformations (a ‘deformation atlas’) via a biphasic-biomechanical-model accounting for brain deformation associated with cerebrospinal fluid drainage, osmotic agents, resection, and swelling. Intraoperatively, an inverse problem approach is employed to provide a combinatory fit from the atlas that best matches sparse intraoperative measurements. Subsequently, preoperative image is deformed accordingly to better reflect patient’s intraoperative anatomy. While we have performed several retrospective studies examining model’s accuracy using post- or intra-operative magnetic resonance imaging, one challenging task is to examine model’s ability to recapture shift due to the aforementioned effects independently with clinical data and in a longitudinal manner under varying conditions. The work here is a case study where swelling was observed at the initial stage of surgery (after craniotomy and dura opening), subsequently sag was observed in a later stage of resection. Intraoperative tissue swelling and sag were captured via an optically tracked stylus by identifying cortical surface vessel features (n = 9), and model-based correction was performed for these two distinct types of brain shift at different stages of the procedure. Within the course of the entire surgery, we estimate the cortical surface experienced a deformation trajectory absolute path length of approximately 19.4 &plusmn; 2.1 mm reflecting swelling followed by sag. Overall, model reduced swelling-induced shift from 7.3 &plusmn; 1.1 to 1.8 &plusmn; 0.5 mm (~74.6% correction); for subsequent sag movement, model reduced shift from 6.4 &plusmn; 1.5 to 1.4 &plusmn; 0.5 mm (~76.6% correction).
Quantum Abstraction Interface: Facilitating Integration of QKD Devices in SDN Networks (2020)

This work presents and implements Quantum Abstraction Interface (QuAI). QuAI is integrated in an SDN agent to enable the vendor agnostic configuration of QKD devices. The work demonstrates the framework to provide a flexible procedure to integrate QKD devices in production networks.
Figure S12 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy (2023)

&lt;p&gt;Supplementary Figure 12: HLA-DR and NKG2D abundance on peripheral lymphocytes associate with longer progression free survival.&lt;/p&gt;
An Experimental and Theoretical Study of a Coupling Mechanism Between Longitudinal and Torsional Drillstring Vibrations at the Bit (1988)

Summary A mechanism that couples longitudinal and torsional drillstring vibrations at the bit was studied. Torsional vibrations are associated with dynamic variations of the rotational bit speed. When a roller bit runs over a multilobed pattern, these speed variations have been shown to affect the input of longitudinal vibrations. The theory for this coupling mechanism is verified experimentally by high-rate data of near-bit accelerations and torque recorded in a 1000-m [3,280-ft] -deep well.
Organization of Frequency Spectra of Atrial Fibrillation: Relevance to Radiofrequency Catheter Ablation (2006)

A higher organization index of atrial electrograms is associated with termination of AF during limited ablation. This parameter may be useful to anticipate the extent of ablation.
Supplementary Material for: The Janus Face of a-Toxin: A Potent Mediator of Cytoprotection in Staphylococci-Infected Macrophages (2017)

After phagocytosis by macrophages, <i>Staphylococcus aureus</i> evades killing in an a-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like <i>MCL-1 (myeloid cell leukemia-1)</i>. Here, using purified a-toxin and a set of <i>hla</i>-deficient strains, we show that a-toxin is critical for the induction of <i>MCL-1 </i>expression and the cytoprotection of infected macrophages. Extracellular or intracellular treatment of macrophages with a-toxin alone did not induce cytoprotection conferred by increased Mcl-1, suggesting that the process is dependent on the production of a-toxin by intracellular bacteria. The increased expression of <i>MCL-1</i> in infected cells was associated with enhanced NFκB activation, and subsequent IL-6 secretion. This effect was only partially inhibited by blocking TLR2, which suggests the participation of intracellular receptors in the specific recognition of <i>S. aureus </i>strains secreting a-toxin. Thus, <i>S. aureus</i> recognition by intracellular receptors and/or activation of downstream pathways leading to Mcl-1 expression is facilitated by a-toxin released by intracellular bacteria which permeabilize phagosomes, ensuring pathogen access to the cytoplasmatic compartment. Given that the intracellular survival of <i>S. aureus</i> depends on a-toxin, we propose a novel role for this agent in the protection of the intracellular niche, and further dissemination of staphylococci by infected macrophages.