gebhart/patrepeval huggingface dataset:
Field-Driven Hopping Transport of Oxygen Vacancies in Memristive Oxide Switches with Interface-Mediated Resistive Switching (2018)

The dynamics of mobile oxygen vacancies depend on electric field and temperature, and this is key to controlling interfacial resistive switching in BiFeO${}_{3}$ memristive devices, which are interesting especially for neuromorphic computing. The authors use impedance spectroscopy and quasistatic state measurements to reveal the dynamics of resistance changes in such devices, and relate these changes to the redistribution of oxygen vacancies via modeling. This work will also impact the use of other oxides with mobile oxygen vacancies in similar devices.
Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects (2021)

SARS-CoV-2 is one of three coronaviruses that have crossed the animal-to-human barrier and caused widespread disease in the past two decades. The development of a universal human coronavirus vaccine could prevent future pandemics. We characterize 198 antibodies isolated from four COVID-19+ subjects and identify 14 SARS-CoV-2 neutralizing antibodies. One targets the N-terminal domain (NTD), one recognizes an epitope in S2, and 11 bind the receptor-binding domain (RBD). Three anti-RBD neutralizing antibodies cross-neutralize SARS-CoV-1 by effectively blocking binding of both the SARS-CoV-1 and SARS-CoV-2 RBDs to the ACE2 receptor. Using the K18-hACE transgenic mouse model, we demonstrate that the neutralization potency and antibody epitope specificity regulates the in vivo protective potential of anti-SARS-CoV-2 antibodies. All four cross-neutralizing antibodies neutralize the B.1.351 mutant strain. Thus, our study reveals that epitopes in S2 can serve as blueprints for the design of immunogens capable of eliciting cross-neutralizing coronavirus antibodies.
Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice (2001)

Background- To investigate the role of endothelial nitric oxide synthase (NOS3) in left ventricular (LV) remodeling after myocardial infarction (MI), the impact of left anterior descending coronary artery ligation on LV size and function was compared in 2- to 4-month-old wild-type (WT) and NOS3-deficient mice (NOS3(-/-)). Methods and Results- Two days after MI, both strains of mice had a similar LV size, fractional shortening, and ejection fraction by echocardiography. Twenty-eight days after MI, both strains had dilated LVs with decreased fractional shortening and lower ejection fractions. Although the infarcted fraction of the LV was similar in both strains, LV end-diastolic internal diameter, end-diastolic volume, and mass were greater, but fractional shortening, ejection fraction, and the maximum rate of developed LV pressure (dP/dt(max)) were lower in NOS3(-/-) than in WT mice. Impairment of diastolic function, as measured by the time constant of isovolumic relaxation (tau) and the maximum rate of LV pressure decay (dP/dt(min)), was more marked in NOS3(-/-) than in WT mice. Mortality after MI was greater in NOS3(-/-) than in WT mice. Long-term administration of hydralazine normalized blood pressure in NOS3(-/-) mice, but it did not prevent the LV dilatation, impaired systolic and diastolic function, and increased LV mass that followed MI. In WT mice, capillary density and myocyte width in the nonischemic portion of the LV did not differ before and 28 days after MI, whereas in NOS3(-/-) mice, capillary density decreased and myocyte width increased after MI, whether or not hydralazine was administered. Conclusions- These results suggest that the presence of NOS3 limits LV dysfunction and remodeling in a murine model of MI by an afterload-independent mechanism, in part by decreasing myocyte hypertrophy in the remote myocardium.
Suprachoroidal–transretinal stimulation: a new approach for retinal prostheses (2019)

According to the World Health Organization, there are more than 40 million blind patients in the world. Retinitis pigmentosa (RP) and age-related macular degeneration are two common causes. Retinal prostheses for artificial vision are among the promising approaches. A retinal prosthesis is a device that restores the sense of vision by means of electrical stimulation of the retina. Electrical stimulation applied to the eye produces visual sensations called phosphenes in healthy subjects and blind patients with RP. For clinical application of suprachoroidal- transretinal stimulation (STS), it is necessary to develop a surgical technique for multielectrode array implantation. The surgical procedure for electrode implantation was accomplished without serious complications. No retinal damage was observed around the area of the electrode array on histologic examination of the retinal tissue. These results suggest that the surgery is safe and appropriate to stimulate the retina by means of STS.
Measurement of the [bar over B][0 over s] Meson Lifetime in D[+ over s]π[superscript −] Decays (2014)

We present a measurement of the ratio of the [bar over B][0 over s] meson lifetime, in the flavor-specific decay to D[+ over s]π[superscript −], to that of the [bar over B][superscript 0] meson. The pp collision data used correspond to an integrated luminosity of 1 fb[superscript −1], collected with the LHCb detector, at a center-of-mass energy of 7 TeV. Combining our measured value of 1.010 ± 0.010 ± 0.008 for this ratio with the known [bar over B][superscript 0] lifetime, we determine the flavor-specific [bar over B][0 over s] lifetime to be τ([bar over B][0 over s]) = 1.535 ± 0.015 ± 0.014 ps, where the uncertainties are statistical and systematic, respectively. This is the most precise measurement to date, and is consistent with previous measurements and theoretical predictions.
Abstract 18285: Discordant Impact of Baroreflex Activation on Cardiac Output Between the Normal Heart and Failing Heart (2014)

Introduction: Baroreflex stabilizes arterial pressure (AP) through modulating sympathetic nervous activity (SNA). We previously reported that arterial changes in resistance and stressed blood volume predominantly contribute to the baroreflex control of AP (AHA 2013). It has been well established that cardiac output (CO) of the normal heart increases greatly with increases in preload, while hardly decreases with increases in afterload. The CO dependence of preload and afterload are opposite in the failing heart. Therefore it is conceivable that the impact of baroreflex activation on CO is discordant between the normal heart and failing heart. Hypothesis: We hypothesized that baroreflex activation increases CO in the normal heart, while decreases CO in the failing heart. Methods: We used 5 normal and 5 pacing induced heart failure dogs (ejection fraction of 20-30%). Under general anesthesia, we isolated both carotid sinuses and connected them to a servo-controlled piston pump to control intra-sinus pressure (CSP). We set CSP at 80mmHg to allow hemodynamics to reach steadystate. We then increased CSP to 160 mmHg to activate baroreflex and suppress SNA in both group. We measured right atrial pressure (RAP), left atrial pressure (LAP), mean AP and CO. Results: In the normal heart, activation of baroreflex did not change LAP (5 ± 1 mmHg vs. 4 ± 1 mmHg, p=ns) or RAP (3 ± 1 mmHg vs. 3 ± 1 mmHg, p=ns) but markedly decreased AP (166 ± 21 mmHg vs. 89 ± 20 mmHg, p Conclusions: Activation of baroreflex strikingly reduces LAP and increases CO in dogs with failing heart. The beneficial impacts result from the preload insensitivity and afterload sensitivity of CO in the failing heart. This mechanism may serve as a novel therapeutic strategy for decompensated heart failure.
Projection-Based Anti-Windup for Multivariable Control with Heat Pump Application (2019)

We present an anti-windup method in which the Hanus conditioning technique is combined with a user-designed projection of the reference onto the set of feasible steady-state points. This hybrid approach allows the designer to define a policy for steady-state reference tracking which is used to define the reference projection in the case that one or more control inputs saturate. The projection is computed only when the reference input changes, and is therefore less computationally taxing when compared to a command governor or model predictive control, for some applications. We demonstrate the method with an H-infinity loop-shaping controller for a multi-zone heat pump system in simulation.
60-GHz Single Flux Quantum Pulse Transfer Circuit for Serial Biasing (2023)

Serial Biasing (SB) is a technique to reduce the total DC bias current of Rapid Single Flux Quantum (RSFQ) circuits by partitioning a design into several islands with isolated grounds and sequential biasing. In this paper we focus on the design of a driver-receiver pair (DRP) to transfer pulses between islands that are galvanically isolated for pulse streams. We discuss both DRP itself and the structure for its testing, that comprises several DRPs connected in series, on-chip pseudo random binary sequence (PRBS) generator for circuit stimulation, and HF output interface. We use the layout of DRPs’ chain as an example to illustrate the advantage of the grapevine (GV) approach, introduced earlier, to manage the bias current flowing into and out of an island. The GV current management technique is analyzed by both electromagnetic simulations and measurement, compared, and contrasted with the so-called ‘straightforward’ (SF) approach. The maximum operational frequency for SF test structure was 10 GHz with zero margins for the SB current. Measurements of the GV structure at 10 GHz demonstrated BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−12</sup> with ±5.8% margins for SB current. We observed the correct operation of the 5-island DRP chain up to 60 GHz using the grapevine approach for SB current management. All chips were fabricated at MIT Lincoln Laboratory using SFQ5ee fab node.
Multiterawatt three-cycle optical parametric chirped pulse amplifier (2007)

Optical parametric chirped pulse amplification is one of the most promising techniques for the amplification of few-cycle pulses. We show amplification and compression to the multiterawatt level of near transform-limited three-optical-cycle pulses.
Nuclear-driven flashlamp pumping of the atomic iodine laser (1992)

This report is a study of the atomic iodine laser pumped with nuclear- excited XeBr fluorescence. Preliminary experiments, conducted in the TRIGA reactor investigated the fluorescence of the excimer XeBr under nuclear pumping with {sup 10}B and {sup 3}He, for use as a flashlamp gas to stimulate the laser. These measurements included a determination of the fluorescence efficiency (light emitted in the wavelength region of interest, divided by energy deposited in the gas) of XeBr under nuclear pumping, with varying excimer mixtures. Maximum fluorescence efficiencies were approximately 1%. In order to better understand XeBr under nuclear excitation, a kinetics model of the system was prepared. The model generated the time-dependant concentrations of 20 reaction species for three pulse sizes, a TRIGA pulse, a fast burst reactor pulse, and an e-beam pulse. The modeling results predicted fluorescence efficiencies significantly higher (peak efficiencies of approximately 10%) than recorded in the fluorescence experiments. The cause of this discrepancy was not fully determined. A ray tracing computer model was also prepared to evaluate the efficiency with which nuclear-induced fluorescence generated in one cavity of a laser could be coupled into another cavity containing an iodine lasant. Finally, an experimental laser cell was constructed to verify that nuclear-induced XeBr fluorescence could be used to stimulate a laser. Lasing was achieved at 1.31 micron in the TRIGA using C{sub 3}F{sub 7}I, a common iodine lasant. Peak laser powers were approximately 20 mW. Measured flashlamp pump powers at threshold agreed well with literature values, as did lasant pressure dependency on laser operation.
Proceedings of the sixth ACM international conference on Web search and data mining (2013)

We are delighted to welcome you to the sixth ACM International Conference on Web Search and Data Mining (WSDM 2013) held on February 4-8, 2013, in Rome, Italy. As in the previous years, WSDM has attracted an impressive number of submissions tackling the most recent technical challenges in Web search and data mining, with an ever-growing interest in their social aspects. Now in its sixth year, the conference has reached maturity and has become a leading forum for disseminating the latest research developments in the field. We are happy to present here the proceedings of the conference.

We received a total of 387 submissions (compared to 362 of the last year) from 36 countries and regions, out of which 73 were accepted for full paper publication in the proceedings, thus reaching an acceptance rate of 18.9% (compared to 20.7% of last year and 22.3% of two years ago). The authors of the accepted papers are from 20 countries, spanning four continents - making this a truly international forum. Oral presentation slots were allocated to all papers. Yet, in order to maintain the single-track model that most attendees prefer, we preserved this year the format with spotlight type and type presentations. Out of the 73 accepted papers, 40 were assigned a spotlight slot, while 33 were assigned a plenary slot. The type of slot was chosen by the Program Chairs, mostly based on whether the topic and the content of the paper were best suited for a large group presentation or for a more focused and interactive spotlight style of presentation.
Feasibility of 1 terabit/s (25 ch×40 Gbit/s) global-distance, optically regenerated systems (2003)

The theoretical feasibility of 1 Tbit/s optically regenerated systems over 10,000 km is investigated. The role of key parameters (fiber dispersion slope, mode area, channel and regenerator spacing) on system performance is analyzed.
Quality Management in Middle Ear Surgery: Controversies Regarding Preoperative Imaging (2010)

Today a large variety of different imaging techniques are available for middle ear investigation. However, imaging is not suitable to give essential information in every case on the surgical strategy to be chosen. This article discusses the most frequent indications for preoperative imaging and the relevant techniques. CT scanning, MRI and rotational tomography are taken into consideration as well as traditional X-ray investigations like e.g. 'Schüller's view'. In general, preoperative imaging should only be performed in a patient if certain specific questions can be answered. The experience of the investigator to interpret the images may influence the choice of imaging as well as the equipment he has access to.
Nanostructuration of titania films prepared by self‐assembly to affect cell adhesion (2009)

Nanostructured and dense titania films prepared by evaporation-induced self-assembly (EISA) are shown to possess tunable topographical nanoscale features on the order 2-12 nm. Thermal treatment (calcination) induces a transition from amorphous titania to crystalline anatase that modifies the chemical and structural properties of the surfaces via the migration of matter. For nanostructured films, the nanoporous network changes from organized ellipsoidal pores, approximately 4 nm x 2 nm, to a grid-like structure with pores on the order of 12 nm, whereas dense films show a slight roughening of the surface. Cells seeded on templated films show measurable, statistically significant differences in morphology compared with cells seeded on dense films. Moreover, although crystallization of templated films results in surfaces that promote less well-spread cells with higher circularities, the opposite trend is observed for dense films. As such, these results represent a new method to tailor interfaces for biomaterial applications, using EISA to control material patterning on the nanoscale. This self-assembly based approach allows the patterning on size scales that are inaccessible by most traditional techniques while offering the added potential to package and control the release of bioactive molecules.
In vivo effect of hydroxyurea on orotic acid synthesis. (1966)

Hydroxyurea is thought to inhibit DNA synthesis but the site of inhibition has not been established. The urinary excretion of orotic acid was measured in 6 patients, 5 with acute leukemia and 1 with metastatic melanoma, receiving 6-azauridine which is known to inhibit orotidylic decarboxylase. The orotic aciduria observed in these patients was reversed by the addition of hydroxyurea, suggesting inhibition of de novo pyrimidine biosynthesis at a step prior to the formation of orotic acid. No clear-cut potentiation of a chemotherapeutic effect of this combination of drugs was observed.
ChemInform Abstract: SYNTHETIC INTERMEDIATES POTENTIALLY USEFUL FOR THE SYNTHESIS OF TETRODOTOXIN AND DERIVATIVES. 9. HYDROQUINAZOLINES POSSESSING THE CARBON SKELETON OF TETRODOTOXIN (1984)

Abstract Die Pyrimidinone(I), deren Darstellung in einer früheren Arbeit beschrieben wird, werden als Dienophile eingesetzt.
Functionality Demonstration of a High-Density 1.1V Self-Aligned Split-Gate NVM Cell Embedded into LP 40 nm CMOS for Automotive and Smart Card Applications (2015)

This paper successfully demonstrates a functional and reliable self-aligned, split-gate NVM cell, down to a very competitive and small cell size. This NVM cell is embedded into a 40 nm Low Power (LP) ground rule logic process with copper low-K interconnects. The self- alignment sequence with gate spacer and poly CMP (Chemical Mechanical Polishing) provides an optimized and small cell that can be easily integrated in the standard logic process, in a modular way. This is the first time that the industry has demonstrated a functional split-gate embedded Flash memory cell at 1.1V VDD. This embedded Flash process also yielded on a baseline 32 Mb high-density SRAM test chip as well as a 10% larger automotive-grade embedded Flash cell. We have further demonstrated reliability data that met the tightest market requirements, with a more relaxed 55 nm ground rule on a 16 Mb test array, using the same 40 nm LP process.
Lysosomal Hydrolases in Different Compartments of Rheumatoid and Osteoarthrotic Joints (1981)

Tissue samples from 226 rheumatoid and osteoarthrotic joints displayed increased activities of three lysosomal enzymes compared with controls. Variations in activity were evident--one tissue cannot be blamed for all joint destruction, no one enzyme can be used as a diagnostic tool. Free enzyme activities in synovial fluid reflected those in tissues, especially in cartilage and bone. Increased values in osteoarthrotic sera, close correlation of ESR to activities in joint compartments, and higher values in synovial fluid, cartilage and bone of seronegative rheumatoid patients were recorded.
Enantiomerically Pure Amino Alcohols and Diamino Alcohols from L-Aspartic Acid. Application to the Synthesis of Epi- and Diepislaframine (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiomerically Pure Amino Alcohols and Diamino Alcohols from L-Aspartic Acid. Application to the Synthesis of Epi- and DiepislaframinePeter Gmeiner, Dagmar Junge, and Annerose KaertnerCite this: J. Org. Chem. 1994, 59, 22, 6766–6776Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a042https://doi.org/10.1021/jo00101a042research-articleACS PublicationsRequest reuse permissionsArticle Views1052Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimization of directed self-assembly hole shrink process with simplified model (2014)

Application of the directed self-assembly of block copolymer to the hole shrink process has gained large attention because of the low cost and high potential for sublithographic patterning. In this study, we have employed a simplified model, called the Ohta-Kawasaki model to find the optimal process conditions, which minimize the morphological defects of the diblock copolymer, PS-b-PMMA. The model parameters were calibrated with cross-sectional transmission electron microscopy images. Our simulation results revealed that it is difficult to eliminate the morphological defects (i.e., PS residual layer) by only varying the shape of the guide hole. It turned out that changing the affinity of the bottom surface of the guide hole from "PMMA attractive" to "neutral" is a more effective way to obtain a reasonably wide, defect-free process window. Note that our simulations are not only computationally inexpensive, but are also comparable to the other detailed models such as the selfconsistent field theory; they may also be feasible for large-scale simulations such as the hotspot analysis over a large area.
Cardiac Resynchronization Therapy in Heart Failure Patients with Less Severe Left Ventricular Dysfunction (2014)

Abstract Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF &amp;gt;35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.
Treatment of experimental salmonellosis in mice with ampicillin-bound nanoparticles (1989)

We tested the effectiveness of ampicillin bound to nanoparticles of polyisohexylcyanoacrylate (PIHCA) in treating C57BL/6 mice experimentally infected with Salmonella typhimurium C5. The diameter of the nanoparticles was 187 +/- 13 nm, and the ampicillin/PIHCA ratio was 0.2/1. The proportion of ampicillin bound was 90 +/- 3%. All control mice and all those treated with nonloaded nanoparticles died within 10 days of infection. By contrast, all mice treated with a single injection of 0.8 mg of nanoparticle-bound ampicillin survived. With free ampicillin, a similar curative effect required three doses of 32 mg each. Lower doses delayed but did not reduce mortality. The sharp increase in the therapeutic index of ampicillin after linkage to PIHCA nanoparticles was explained by studies of the distribution of ampicillin, which showed that when bound to nanoparticles, the ampicillin was concentrated mainly in the liver and spleen, the primary foci of infection in the experimental model that we used. These findings warrant further development of intracellular targeting of antibiotics on biodegradable polymeric carriers such as PIHCA.