gebhart/patrepeval huggingface dataset:
COP1, the Negative Regulator of p53, Is Overexpressed in Breast and Ovarian Adenocarcinomas (2004)

The tumor suppressor protein p53 plays a central role in protecting normal cells from undergoing transformation. Thus, it is fitting that cancer cells selectively dampen the p53 response to gain a selective growth advantage. In fact, the p53 gene is the most commonly mutated tumor suppressor gene in human cancers, and if the gene is not mutated, then other components of the p53 pathways are skewed to dampen the p53 response to stress. We recently identified COP1 as a novel and critical negative regulator of p53. COP1 is a RING finger-containing protein that targets p53 for degradation to the proteasome and is necessary for p53 turnover in normal and cancer cells. However, the association between COP1 and cancer remains to be determined. We performed expression analysis of COP1 in ovarian and breast cancer tissue microarrays. COP1 is significantly overexpressed in 81% (25 of 32) of breast and 44% (76 of 171) of ovarian adenocarcinoma as assessed by in situ hybridization and immunohistochemistry. Overexpression of COP1 correlated with a striking decrease in steady state p53 protein levels and attenuation of the downstream target gene, p21, in cancers that retain a wild-type p53 gene status. Overall, these results suggest that overexpression of COP1 contributes to the accelerated degradation of p53 protein in cancers and attenuates the tumor suppressor function of p53.
Regiospecific Azidoiodination of Alkenes with Sodium Periodate, Potassium Iodide, and Sodium Azide: A High-Yield Synthesis of β-Iodoazides (2010)

The combination of sodium periodate, potassium iodide, and sodium azide has been found to be an efficient, simple, and inexpensive reagent system for azidoiodination of alkenes. The regiospecific 1,2-azidoiodination proceeds in an anti-Markovnikov fashion to produce β-iodoazides in excellent yields.
ChemInform Abstract: COMPLEX CHEMISTRY OF REACTIVE ORGANIC COMPOUNDS. XXXIV. INCORPORATION OF DIAZOMETHANE INTO CARBONYLMANGANESE AND ‐RHENIUM COMPLEXES (1980)

Abstract Eine Lösung des Mn‐Carbonylkomplexes (Ia) reagiert mit Diazomethan (II) in THF unter Bildung der Verbindungen (III) und (IVa).
Nephrogenic Systemic Fibrosis and Gadolinium-Containing Radiological Contrast Agents: An Update (2011)

Nephrogenic systemic fibrosis (NSF), originally described as “scleromyxedema-like cutaneous disease,” is an entity that has emerged recently in patients with renal dysfunction.1 NSF is a rare but severely disabling disease that manifests as fibrosis of skin and viscera. Numerous reports have highlighted an association between NSF and gadolinium (Gd)-based contrast agents (GBCAs) used for magnetic resonance imaging. The exact mechanisms underlying this association are still under investigation.2,3 There were apparently no reports of NSF prior to 1997, when the first cases were described.1 Clinical Pharmacology & Therapeutics (2011) 89 6, 920–923. doi:10.1038/clpt.2010.346
Enhanced scattering from nano-particles trapped in photonic crystal membranes (2012)

We present simulations showing how light scattered by isolated particles increases by a factor 10, when they are placed in photonic crystal membranes. Exploiting this effect, single nano-particles have been detected with an optical microscope.
Experimental Characterization of Transient Tone Deviation in Print Jobs for Color Electrophotography (2012)

Print quality tests using off-the-shelf color electrophotographic printers revealed systematic tone fluctuations among the first several pages in print jobs after idle periods as short as 1 min, under certain environmental conditions. It can be shown that the tone values on the first few pages of a print job after 1 min of idle are statistically different from the tone values on the other pages of the same job. In the mid-tone ranges, the mean tone value difference between pages can differ by 4 &#x394;E76 units under low temperature and low humidity conditions. This article presents an experimental approach to characterize this type of transient tone deviation in a print job for tone consistency control and improvement. A first-order difference model is employed to approximate the transient tone deviation. The resulting model can accurately predict the transient tone deviation over pages to within 1.3 &#x394;E76 units, based on cross-validation.
Brief Discussion of 802.11n and Concluding Remarks (2007)

This chapter contains sections titled: Need for 802.11n 802.11a/b/g/n MIMO Transceiver Concluding Remarks
Faster, parametric trajectory-based macromodels via localized linear reductions (2006)

Trajectory-based methods offer an attractive methodology for automated, on-demand generation of macromodels for custom circuits. These models are generated by sampling the state trajectory of a circuit as it simulates in the time domain, and building macromodels by reducing and interpolating among the linearizations created at a suitably spaced subset of the time points visited during training simulations. However, a weak point in conventional trajectory models is the reliance on a single, global reduction matrix for the state space. We develop a new, faster method that generates and weaves together a larger set of smaller localized linearizations for the trajectory samples. The method not only improves speedups to 30X over SPICE, but as a side benefit also provides a platform for parametric small-signal simulation of circuits with variational device/process parameters, at a speedup of roughly 200X over SPICE.
Isolation of Adipose-Derived Stem/Stromal Cells from Cryopreserved Fat Tissue and Transplantation into Rats with Spinal Cord Injury (2018)

Adipose tissue contains multipotent cells known as adipose-derived stem/stromal cells (ASCs), which have therapeutic potential for various diseases. Although the demand for adipose tissue for research use remains high, no adipose tissue bank exists. In this study, we attempted to isolate ASCs from cryopreserved adipose tissue with the aim of developing a banking system. ASCs were isolated from fresh and cryopreserved adipose tissue of rats and compared for proliferation (doubling time), differentiation capability (adipocytes), and cytokine (hepatocyte growth factor and vascular endothelial growth factor) secretion. Finally, ASCs (2.5 × 10⁶) were intravenously infused into rats with spinal cord injury, after which hindlimb motor function was evaluated. Isolation and culture of ASCs from cryopreserved adipose tissue were possible, and their characteristics were not significantly different from those of fresh tissue. Transplantation of ASCs derived from cryopreserved tissue significantly promoted restoration of hindlimb movement function in injured model rats. These results indicate that cryopreservation of adipose tissue may be an option for clinical application.
Supplementary Data from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors (2023)

Supplementary Data from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
Network-Efficient Distributed Word2vec Training System for Large Vocabularies (2016)

Word2vec is a popular family of algorithms for unsupervised training of dense vector representations of words on large text corpuses. The resulting vectors have been shown to capture semantic relationships among their corresponding words, and have shown promise in reducing a number of natural language processing (NLP) tasks to mathematical operations on these vectors. While heretofore applications of word2vec have centered around vocabularies with a few million words, wherein the vocabulary is the set of words for which vectors are simultaneously trained, novel applications are emerging in areas outside of NLP with vocabularies comprising several 100 million words. Existing word2vec training systems are impractical for training such large vocabularies as they either require that the vectors of all vocabulary words be stored in the memory of a single server or suffer unacceptable training latency due to massive network data transfer. In this paper, we present a novel distributed, parallel training system that enables unprecedented practical training of vectors for vocabularies with several 100 million words on a shared cluster of commodity servers, using far less network traffic than the existing solutions. We evaluate the proposed system on a benchmark data set, showing that the quality of vectors does not degrade relative to non-distributed training. Finally, for several quarters, the system has been deployed for the purpose of matching queries to ads in Gemini, the sponsored search advertising platform at Yahoo, resulting in significant improvement of business metrics.
NOMA Aided Narrowband IoT for Machine Type Communications with User\n Clustering (2018)

To support Machine Type Communications (MTC) in next generation mobile\nnetworks, NarrowBand-IoT (NB-IoT) has been released by the Third Generation\nPartnership Project (3GPP) as a promising solution to provide extended coverage\nand low energy consumption for low cost MTC devices. However, the existing\nOrthogonal Multiple Access (OMA) scheme in NB-IoT cannot provide connectivity\nfor a massive number of MTC devices. In parallel with the development of\nNB-IoT, Non-Orthogonal Multiple Access (NOMA), introduced for the fifth\ngeneration wireless networks, is deemed to significantly improve the network\ncapacity by providing massive connectivity through sharing the same spectral\nresources. To leverage NOMA in the context of NB-IoT, we propose a power domain\nNOMA scheme with user clustering for an NB-IoT system. In particular, the MTC\ndevices are assigned to different ranks within the NOMA clusters where they\ntransmit over the same frequency resources. Then, we formulate an optimization\nproblem to maximize the total throughput of the network by optimizing the\nresource allocation of MTC devices and NOMA clustering while satisfying the\ntransmission power and quality of service requirements. We prove the\nNP-hardness of the proposed optimization problem. We further design an\nefficient heuristic algorithm to solve the proposed optimization problem by\njointly optimizing NOMA clustering and resource allocation of MTC devices.\nFurthermore, we prove that the reduced optimization problem of power control is\na convex optimization task. Simulation results are presented to demonstrate the\nefficiency of the proposed scheme.\n
Consensus-based perioperative protocols during the COVID-19 pandemic (2020)

Urgent and emergent invasive procedures need to be performed during the COVID-19 pandemic. The consensus-based protocols in this study may assist healthcare providers to optimize perioperative care during the pandemic.
Virtual Cells for 5G V2X Communications (2018)

The virtual cell (VC) is an emergent concept in cellular networks that shifts the base-station-centric point of view to a user-centric one. Instead of a single base station, VCs consist of a number of transmission points with an association pattern that is created for, and moves with, every user in the network. A particularly challenging application of VCs is that of V2X communications, where V2X messages are broadcast to groups of vehicles. In this scenario, a VC is not created for a single device but for hotspots that move over time. In this article, we present a realization of the VC concept for V2X broadcast groups. The proposed solution consists of three optimization stages, which are admission control, transmission weight selection, and power control.
Lyophilic (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
The p14ARF Alternate Reading Frame Protein Enhances DNA Binding of Topoisomerase I by Interacting with the Serine 506-Phosphorylated Core Domain (2013)

In addition to its well-characterized function as a tumor suppressor, p14ARF (ARF) is a positive regulator of topoisomerase I (topo I), a central enzyme in DNA metabolism and a target for cancer therapy. We previously showed that topo I hyperphosphorylation, a cancer-associated event mediated by elevated levels of the protein kinase CK2, increases topo I activity and the cellular sensitivity to topo I-targeted drugs. Topo I hyperphosphorylation also increases its interaction with ARF. Because the ARF-topo I interaction could be highly relevant to DNA metabolism and cancer treatment, we identified the regions of topo I involved in ARF binding and characterized the effects of ARF binding on topo I function. Using a series of topo I deletion constructs, we found that ARF interacted with the topo I core domain, which encompasses most of the catalytic and DNA-interacting residues. ARF binding increased the DNA relaxation activity of hyperphosphorylated topo I by enhancing its association with DNA, but did not affect the topo I catalytic rate. In cells, ARF promoted the chromatin association of hyperphosphorylated, but not basal phosphorylated, topo I, and increased topo I-mediated DNA nicking under conditions of oxidative stress. The aberrant nicking was found to correlate with increased formation of DNA double-strand breaks, which are precursors of many genome destabilizing events. The results suggest that the convergent actions of oxidative stress and elevated CK2 and ARF levels, which are common features of cancer cells, lead to a dysregulation of topo I that may contribute both to the cellular response to topo I-targeted drugs and to genome instability.
Silicon-platformed nonlinear waveguide in lithium niobate membrane (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Utsugida, S. Kurimura, Y. Muranaka, E. Mochizuki, and H. Nakajima, "Silicon-platformed nonlinear waveguide in lithium niobate membrane," in CLEO: 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper CW1O.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
Physically constrained maximum likelihood mode filtering (2010)

Mode filtering is most commonly implemented using the sampled mode shapes or pseudoinverse algorithms. Buck et al. [J. Acoust. Soc. Am. 103, 1813-1824 (1998)] placed these techniques in the context of a broader maximum a posteriori (MAP) framework. However, the MAP algorithm requires that the signal and noise statistics be known a priori. Adaptive array processing algorithms are candidates for improving performance without the need for a priori signal and noise statistics. A variant of the physically constrained, maximum likelihood (PCML) algorithm [A. L. Kraay and A. B. Baggeroer, IEEE Trans. Signal Process. 55, 4048-4063 (2007)] is developed for mode filtering that achieves the same performance as the MAP mode filter yet does not need a priori knowledge of the signal and noise statistics. The central innovation of this adaptive mode filter is that the received signal's sample covariance matrix, as estimated by the algorithm, is constrained to be that which can be physically realized given a modal propagation model and an appropriate noise model. Shallow water simulation results are presented showing the benefit of using the PCML method in adaptive mode filtering.
Process Characterization for Integration of Esaki Diodes into Aspect Ratio Trapping Material (2008)

A process for forming Esaki Diodes in Germanium bulk material was characterized. In doing so its processing characteristics were studied to determine whether it could be transferred into Aspect Ratio Trapping, ART, material. It was determined that transfer was feasible with the optimization of the spin on dopant process and strict control of the wet etching of the spin on dopant and Aluminum. Following process characterization electrical data was collected for a range of devices with varying process parameters. The maximum peak to valley current ratio was 1.5 and maximum peak current density was 5kA/cm2. The PVCR value was very close to data collected by a group at Notre Dame who’s process was the basis for the one used in this project4. However, the maximum peak current density was much lower, most likely due the decreased dopant concentration of the spin on dopant. Upon completion of the project a process, which could be transferred to ART, was obtained and baseline data was collected for comparison to future devices.
ChemInform Abstract: Fluorescent Properties of Model Chromophores of Tyrosine‐66 Substituted Mutants of Aequorea Green Fluorescent Protein (GFP). (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photo-patternable ion gel-gated graphene transistors and inverters on plastic (2013)

We demonstrate photo-patternable ion gel-gated graphene transistors and inverters on plastic substrates. The photo-patternable ion gel can be used as a negative photoresist for the patterning of underlying graphene as well as gate dielectrics. As a result, an extra graphene-patterning step is not required, which simplifies the device fabrication and avoids a side effect arising from the photoresist residue. The high capacitance of ion gel gate dielectrics yielded a low voltage operation (~2 V) of the graphene transistor and inverter. The graphene transistors on plastic showed an on/off-current ratio of ~11.5, along with hole and electron mobilities of 852 ± 124 and 452 ± 98 cm(2) V(-1) s(-1), respectively. In addition, the flexible graphene inverter was successfully fabricated on plastic through the potential superposition effect from the drain bias. These devices show excellent mechanical flexibility and fatigue stability.
Room Temperature Hydroalkylation of Electron-Deficient Olefins:  sp3 C−H Functionalization via a Lewis Acid-Catalyzed Intramolecular Redox Event (2005)

A practical method for the intramolecular hydroalkylation of electron-deficient olefins has been developed. The direct transformation of benzylic, tertiary, and sterically hindered secondary sp3 C-H bonds into C-C bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.
Arterial and venous blood flow: noninvasive quantitation with MR imaging. (1992)

Quantitative measurements of arterial and venous blood flow were obtained with phase-contrast cine magnetic resonance (MR) imaging and compared with such measurements obtained by means of implanted ultrasound (US) blood flow probes in anesthetized dogs. The US flowmeter was enabled during a portion of each MR imaging sequence to allow virtually simultaneous data acquisition with the two techniques. MR imaging data were gated by means of electrocardiography and divided into 16 phases per cardiac cycle. The rates of portal venous blood flow measured with MR imaging and averaged across the cardiac cycle (710 mL/min +/- 230 [standard deviation]) correlated well with those measured with the flowmeter and averaged in like fashion (751 mL/min +/- 238) (r = .995, slope = 1.053). The correspondence in arterial blood flow was almost as good. No statistically significant difference existed between the paired measurements of blood flow obtained with MR imaging and the implanted probe. It is concluded that, as a noninvasive means of accurate quantification of blood flow, phase-contrast MR imaging may be especially useful in deep blood vessels in humans.
A micro-bead device to explore Plasmodium falciparum-infected, spherocytic or aged red blood cells prone to mechanical retention by spleen endothelial slits (2010)

Présentation orale
regulatory T cells on CTL function against MHC alloantigens (2008)

Anterior chamber associated immune deviation (ACAID) is an antigen-specific form of peripheral immunetolerance that is induced to exogenous antigens placed in the ocular anterior chamber, which leads to a suppression indelayed-type hypersensitivity (DTH). Considerable work has been done on ACAID induction to major histocompatibility(MHC) alloantigens. However, its role on cytotoxic T lymphocyte (CTL) activity is currently unknown.
Use of caries prevention services in the Northwest PRECEDENT dental network (2010)

This study reports that aside from prophylaxis, which more than 85% of the patients had received, about one-third of the patients overall received preventive services consisting of either sealants or some type of fluoride treatment in private dental practices in the Northwest PRECEDENT network.
Magnetic Core−Shell Nanoparticles from Nanoscale-Induced Phase Segregation (2016)

Nanoscaling of the nickel phosphides profoundly alters their domains of stability. An original mechanism of “nanoscale-induced phase segregation” was uncovered in the present study: the appearance of two crystallized phases inside each single nanoparticle (here, Ni&lt;sub&gt;2&lt;/sub&gt;P and Ni fcc), where the single-phase product (Ni&lt;sub&gt;3&lt;/sub&gt;P) would have been preferred at the bulk scale. This behavior was obtained by reacting at low temperature (&lt;220 °C) substoichiometric amounts of white phosphorus (P&lt;sub&gt;4&lt;/sub&gt;) on well-defined monodisperse Ni nanoparticles in solution. Phosphorus insertion inside the Ni fcc nanoparticles triggers the crystallization of a Ni&lt;sub&gt;2&lt;/sub&gt;P core surrounded by a Ni shell. The crystallization process was monitored by HRTEM, EFTEM, XRD, and SQUID analyses and revealed a direct transformation of Ni fcc to a core−shell structure without any other Ni&lt;sub&gt;&lt;i&gt;x&lt;/i&gt;&lt;/sub&gt;P&lt;sub&gt;&lt;i&gt;y&lt;/i&gt;&lt;/sub&gt; crystallized intermediate. This core−shell Ni−P system was tuned by adjusting the amount of P&lt;sub&gt;4&lt;/sub&gt; added, providing tunable magnetic shells supported on monodisperse nanoparticles.