gebhart/patrepeval huggingface dataset:
Identification of IL-40, a Novel B Cell–Associated Cytokine (2017)

We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (<i>C17orf99</i>; chromosome 17 open reading frame 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peripheral B cells upon activation. <i>C17orf99</i> is only present in mammalian genomes, and it encodes a small (∼27-kDa) secreted protein unrelated to other cytokine families, suggesting a function in mammalian immune responses. Accordingly, <i>C17orf99</i> expression is induced in the mammary gland upon the onset of lactation, and a <i>C17orf99</i><sup>-/-</sup> mouse exhibits reduced levels of IgA in the serum, gut, feces, and lactating mammary gland. <i>C17orf99</i><sup>-/-</sup> mice have smaller and fewer Peyer's patches and lower numbers of IgA-secreting cells. The microbiome of <i>C17orf99<sup>-/-</sup></i> mice exhibits altered composition, likely a consequence of the reduced levels of IgA in the gut. Although naive B cells can express <i>C17orf99</i> upon activation, their production increases following culture with various cytokines, including IL-4 and TGF-β1, suggesting that differentiation can result in the expansion of <i>C17orf99</i>-producing B cells during some immune responses. Taken together, these observations indicate that <i>C17orf99</i> encodes a novel B cell-associated cytokine, which we have called IL-40, that plays an important role in humoral immune responses and may also play a role in B cell development. Importantly, IL-40 is also expressed by human activated B cells and by several human B cell lymphomas. The latter observations suggest that it may play a role in the pathogenesis of certain human diseases.
Unitary equivalence: a new twist on signal processing (1995)

Unitary similarity transformations furnish a powerful vehicle for generating infinite generic classes of signal analysis and processing tools based on concepts different from time, frequency, and scale. Implementation of these new tools involves simply preprocessing the signal by a unitary transformation, performing standard processing on the transformed signal, and then (in some cases) transforming the resulting output. The resulting unitarily equivalent systems can focus on the critical signal characteristics in large classes of signals and, hence, prove useful for representing and processing signals that are not well matched by current techniques. As specific examples of this procedure, we generalize linear time-invariant systems, orthonormal basis and frame decompositions, and joint time-frequency and time-scale distributions. These applications illustrate the utility of the unitary equivalence concept for uniting seemingly disparate approaches proposed in the literature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Methods from RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis (2023)

&lt;p&gt;Supplementary information on cell maintenance, and antibody selection and characterization&lt;/p&gt;
A new technique to achieve zero voltage switching in resonant reset single switch forward converter (2007)

Zero voltage switching (ZVS) or soft switching is gaining prominence for a variety of reasons. The benefits and the limitations of ZVS are well documented in the literature. Though the true ZVS is possible in full bridge converters, special design considerations need to be addressed in forward converters to achieve true ZVS. In this paper a new technique is proposed to achieve true ZVS without the loss of duty cycle or increased primary circulating currents in a single switch forward converter. Resonant reset technique is adapted for the transformer reset and the same is extended to achieve ZVS .This principle is demonstrated by developing a practical 240 watts DC to DC converter operating at 250 KHz and from a high voltage 400 V DC bus. The measured data depict an improvement in the converter efficiency.
Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity (1996)

Castration in the rat reduces both the erectile response and penile nitric oxide synthase (NOS) activity, and these effects are prevented by androgen administration. In this study we determined that the decrease of penile NOS in the castrated rat is due to NOS enzyme inhibition rather than to a reduction of its content and that this inhibition may be reversed. Adult rats were either castrated or left intact, and, after 1 wk, electrical field stimulation (EFS) was applied to the cavernosal nerve and the penises were excised either at the peak of erection or after detumescence. Penile NOS activity in the non-EFS castrates decreased by 70% as compared with the intact non-EFS-treated controls, but neuronal NOS content remained unaffected despite changes in regional distribution. NOS activity in the castrated penis was restored to normal values by EFS at the peak of stimulation, and then decreased on detumescence. This was in contrast to the intact controls in which EFS did not stimulate penile NOS activity. These data indicate that androgen depletion in the rat reduces penile NOS activity rather than NOS content and that this enzyme inhibition is reversed by cavernosal nerve stimulation.
System Analysis for a Kinematic Positioning System Based on the Global Positioning System (1992)

Destroy this report when no longer needed. Do not return it to the originator. The contents of this report are not to be used for advertising, publication, or promotional purposes. Cilation of trade names does not constitute an official endorsement or approval of the use of such commercial products. form Appiow d
48.2: Light field rendering of multi‐view contents for high density light field 3D display (2013)

Abstract Though the light field display which can reconstruct the directional light field information has several advantages in representing more realistic 3D images, one of the key problems is to generate the light field information from the natural scene. In this paper, we propose a generalized light field rendering method from the multi‐view video contents and show the experiment results in the developed 300Mpixels light field display.
Therapeutic Angiogenesis Using HGF Plasmid (2020)

Hepatocyte growth factor (HGF) is secreted from stromal and mesenchymal cells, and its receptor cMet is expressed on various types of cells such as smooth muscle cells, fibroblast, and endothelial cells. HGF stimulates epithelial and endothelial cell proliferation, motility, and morphogenesis in a paracrine and autocrine manner, organizing multistep of angiogenesis in many organs. In addition, HGF is recognized as a potent anti-inflammatory and anti-fibrotic growth factor, which has been proved in several animal studies, including neointimal hyperplasia and acute myocardial infarction model in rodent. Thus, as compared to other angiogenic growth factors, HGF exerts multiple effects on ischemic tissues, accompanied by the regression of tissue inflammation and fibrosis. These data suggest the therapeutic potential of the HGF for peripheral artery disease as it being accompanied with chronic tissue inflammation and fibrosis. In the present narrative review, the pleiotropic action of the HGF that differentiates it from other angiogenic growth factors is discussed first, and later, outcomes of the human clinical study with gene therapy are overviewed.
Messenger RNA: An Evaluation (1966)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Strong light confinement in a metal-assisted silicon slot waveguide (2014)

A metal-assisted silicon slot waveguide is presented. Numerical results show that the proposed structure achieves a strong light confinement in a low-index region, which leads to the improvement of the sensitivity in refractive index sensors.
Complete Genome Sequence of Brucella abortus Phage EF4, Determined Using Long-Read Sequencing (2020)

Brucellaphage EF4 was isolated from elk feces. The 38,321-bp double-stranded DNA genome is predicted to contain 72 coding regions, 38 of which have been assigned predicted functions. This phage displays nucleotide similarity to other brucellaphages of the genus <i>Perisivirus</i>.
T lymphocyte development and function in dogs with X-linked severe combined immunodeficiency. (1994)

Canine X-linked severe combined immunodeficiency disease (XSCID) is characterized by a failure to thrive, thymic dysplasia, and a lack of a T lymphocyte mitogenic response. As in human XSCID, affected dogs in our colony have a mutation in the IL-2R-gamma gene. This mutation dramatically altered T lymphocyte development, because XSCID thymi were severely reduced in size and cellularity, contained an increased proportion of immature CD4-CD8- thymocytes, a decreased proportion of intermediate CD4+CD8+ thymocytes, and a normal proportion of CD4+CD8- and CD4-CD8+ thymocytes. XSCID thymi were also deficient in the percentage of CD3-L+ thymocytes. Interestingly, several XSCID dogs had normal percentages of CD3-L+ PBL. Although the mutation did not interfere with IL-2 production, PHA-activated XSCID PBL demonstrated severely diminished IL-2 binding and were nonresponsive to IL-2. These results indicate that the lack of a functional IL-2R-gamma chain in dogs with XSCID primarily affects developing CD4-CD8- thymocytes as they acquire the cell surface Ag CD3-L and interferes with the ability of peripheral T lymphocytes to bind and respond to IL-2.
A 30 Gb/s CMOS driver integrated with silicon photonics MZM (2015)

A voltage mode modulator driver is proposed in the TSMC 65nm low power CMOS process. In the electrical testing, the driver itself can achieve a bit rate of 40Gb/s with the single-ended output swing of 1.65V. Unlike equivalent CML modulator drivers, when the proposed driver is integrated with the silicon photonic MZM, it does not require an additional biasing network. The integrated electro-optic transmitter can achieve 30Gb/s with an extinction ratio of 4.05dB, with the power consumption of main driver being 323mW.
Copper-2 Hypothesis for Causation of the Current Alzheimer’s Disease Epidemic Together with Dietary Changes That Enhance the Epidemic (2017)

Alzheimer's disease, the most common cause of dementia, is at epidemic proportions (15 to 44% depending on age, of those age 65 to 84) in the U.S. and other developed countries but remains relatively rare in undeveloped countries. Surprisingly, solid historical data reveal the epidemic is a creature of the last century. That is, the disease was also rare in developed countries, until the 20th century. It is disappointing that these historical and demographic facts have been ignored by the Alzheimer's disease scientific community. Disappointing because these facts clearly point at an environmental change in the 20th century in developed countries as a major factor in causing the epidemic. Some scientists have discarded the claimed rarity of the disease in the 19th century as incorrect, saying that Alzheimer's disease is a disease of aging and that the increasing lifespan of people accounts for the current high prevalence of the disease, but this cavalier attitude ignores historical data indicating there were many elderly people in the 19th century who were not getting Alzheimer's disease with any significant frequency. In this review, after documenting that the observed assertions about historical and demographic facts are correct, evidence is amassed that the main environmental culprit causing the Alzheimer's epidemic is ingestion of divalent copper or copper-2. The two sources of copper-2 ingestion are drinking water and multimineral supplement pills containing copper. The increase in copper plumbing use in developed countries parallels the increasing prevalence of Alzheimer's disease. It has been shown that enough copper is leached from copper plumbing in most households to cause Alzheimer's disease, using the Alzheimer's disease animal model studies as a guide to toxic levels. It is relatively easy to avoid or greatly diminish copper-2 ingestion by not using copper containing supplement pills and testing drinking water for copper levels. If the copper in water is too high, a simple device can be put on the tap to remove copper. In addition to the copper-2 hypothesis, this review covers dietary changes that enhance the epidemic.
Studien zur Chemie der Cinchona Alkaloide (1999)

[no abstract]
Cover Picture: Selective Catalytic Synthesis Using the Combination of Carbon Dioxide and Hydrogen: Catalytic Chess at the Interface of Energy and Chemistry (Angew. Chem. Int. Ed. 26/2016) (2016)

The combination of CO2 and H2 … …as building blocks offers attractive synthetic pathways ranging from large-volume base chemicals to highly functionalized complex molecules. J. Klankermayer, W. Leitner et al. describe in their Review on page 7296 ff. how efficient catalysts are becoming available to master the bond breaking and bond formation events required for these processes like strategic moves on a molecular chess board. The combination of CO2 and H2 … …as building blocks offers attractive synthetic pathways ranging from large-volume base chemicals to highly functionalized complex molecules. J. Klankermayer, W. Leitner et al. describe in their Review on page 7296 ff. how efficient catalysts are becoming available to master the bond breaking and bond formation events required for these processes like strategic moves on a molecular chess board. Metalloborophenes Hierarchical Nanomaterials siRNA Delivery
A comprehensive strategy for longitudinal vehicle control with fuzzy supervisory expert system (2002)

The main objectives of vehicle motion control on an automated highway system are stable and safe automatic longitudinal and/or lateral path following in a platoon of vehicles. Various controllers can be used to satisfy the same objectives, but they may require different variables to be sensed or different conditions to be met. Supervision can select a controller and switch to a different controller depending on the conditions. Specifically, a fuzzy supervisory expert system checks for various system conditions and chooses a controller from PID, PI, sliding mode and a fuzzy controller or gives a distress signal. The choice between PID and PI controllers is based on the availability of the error derivative. Robust and complex sliding mode control can counter the external disturbances which the PID and PI controllers cannot handle. The fuzzy controller is used when the sensors are not working perfectly but the sensor values are still reliable enough to define corresponding fuzzy linguistic variables.
Supplementary Data 1-9 from Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer (2023)

Supplementary Data 1-9 from Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer
Glutamate Decarboxylase from Lactic Acid Bacteria—A Key Enzyme in GABA Synthesis (2020)

Glutamate decarboxylase (l-glutamate-1-carboxylase, GAD; EC 4.1.1.15) is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes the irreversible α-decarboxylation of l-glutamic acid to γ-aminobutyric acid (GABA) and CO<sub>2</sub>. The enzyme is widely distributed in eukaryotes as well as prokaryotes, where it-together with its reaction product GABA-fulfils very different physiological functions. The occurrence of <i>gad</i> genes encoding GAD has been shown for many microorganisms, and GABA-producing lactic acid bacteria (LAB) have been a focus of research during recent years. A wide range of traditional foods produced by fermentation based on LAB offer the potential of providing new functional food products enriched with GABA that may offer certain health-benefits. Different GAD enzymes and genes from several strains of LAB have been isolated and characterized recently. GABA-producing LAB, the biochemical properties of their GAD enzymes, and possible applications are reviewed here.
4′-C-Methyl-β-D-ribofuranosyl Purine and Pyrimidine Nucleosides Revisited (2003)

In order to evaluate their antiviral properties, a series of 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4'-branched nucleosides showed any antiviral activity or cytotoxcity when tested against HIV, HBV, and Yellow Fever virus.
Compact Fabry-Perot cavities in X-band with PEC and PMC boundary conditions (2007)

International audience
Solution NMR structure of the N‐terminal domain of the human DEK protein (2008)

The human DEK protein has a long-standing association with carcinogenesis since the DEK gene was originally identified in the t(6:9) chromosomal translocation in a subtype of patients with acute myelogenous leukemia (AML). Recent studies have partly unveiled DEK's cellular functions including apoptosis inhibition in primary cells as well as cancer cells, determination of 3' splice site of transcribed RNA, and suppression of transcription initiation by polymerase II. It has been previously shown that the N-terminal region of DEK, spanning residues 68-226, confers important in vitro and in vivo functions of DEK, which include double-stranded DNA (ds-DNA) binding, introduction of constrained positive supercoils into closed dsDNA, and apoptosis inhibition. In this paper, we describe the three-dimensional structure of the N-terminal domain of DEK (DEKntd) as determined using solution NMR. The C-terminal part of DEKntd, which contains a putative DNA-binding motif (SAF/SAP motif), folds into a helix-loop-helix structure. Interestingly, the N-terminal part of DEKntd shows a very similar structure to the C-terminal part, although the N-terminal and the C-terminal part differ distinctively in their amino acid sequences. As a consequence, the structure of DEKntd has a pseudo twofold plane symmetry. In addition, we tested dsDNA binding of DEKntd by monitoring changes of NMR chemical shifts upon addition of dsDNAs. We found that not only the C-terminal part containing the SAF/SAP motif but the N-terminal part is also involved in DEKntd's dsDNA binding. Our study illustrates a new structural variant and reveals novel dsDNA-binding properties for proteins containing the SAP/SAF motif.
Longitudinal writing of vertical waveguides in fused silica: Toward new integrated photonic technologies (Conference Presentation) (2018)

In this century of continuous exponential growth of communications worldwide, traditional electrical interconnection is finding increasingly difficult to respond to the bandwidth pressure, and photonic interconnection will most likely be the future standard. Planar lightwave circuit (PLC) technology is capable of high-throughput fabrication of low loss waveguides, but is in general limited to its 2D geometry. On the other hand femtosecond direct writing (FDW) provides a solid tool for the fabrication of optical circuits with great flexibility, exploiting its truly 3D properties, but suffers from higher losses and lower throughput. By combining with PLC technology, FDW could aid in the bridging of different layers of optical circuits, exponentially decreasing their footprint. We report in this work the fabrication of such optical vias. The fabrication of vertical waveguides in fused silica, using a IR femtosecond fiber laser, with parameters optimised to induce the previously reported micro-explosions mechanism inside fused silica. By using a long working distance water immersion objective, we reduced spherical aberrations due to a better phase matching with the glass. A helix path was applied to create a cone of damaged material, leaving a stress-induced central waveguide, with propagation losses lower than 1 dB/mm. Finally, we analyse the possibility of tilting these waveguides and its effect on their optical properties. This feature adds to the flexibility of this method, that could for example accommodate input/output angles of common coupling strategies used with PLC technologies.
On the use of AM1 calculations for the study of intramolecular hydrogen bonding phenomena in simple amides (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the use of AM1 calculations for the study of intramolecular hydrogen bonding phenomena in simple amidesGregory P. Dado and Samuel H. GellmanCite this: J. Am. Chem. Soc. 1992, 114, 8, 3138–3139Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://doi.org/10.1021/ja00034a070RIGHTS & PERMISSIONSArticle Views129Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (304 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Stacked chip scale packages: manufacturing issues, reliability results, and cost analysis (2004)

System requirements for high density packaging have driven the development of chip scale package (CSP) technology. Continuing pressure for improved performance and reduced cost is dictating even greater improvements in functional density. A prime example of this can be found in the escalating requirements for DRAM and other memory modules. Functional integration within the silicon and bare chip stacking are two approaches to these challenges, but they present problems related to cost, time-to-market, testing, and business logistics. Stacking of tested CSPs - rather than bare chips-can address each of the issues because of increased design flexibility, the ability to extend the life of existing products, an established manufacturing infrastructure, and elimination of the technical and business challenges associated with procuring and testing bare die. With proper design, CSP stacking is a straightforward extension of standard packaging and surface mount processes. This paper reviews the manufacturing flow for one such stacked CSP technology, the /spl mu/Z/sup TM/-Ball Stack package. For any such high volume process, reliability is a critical issue, and reliability results for stacked CSP structures are presented. Most often, cost is the ultimate deciding factor in the selection of manufacturing technology, and a detailed cost analysis of package stacking versus die stacking is also presented. Much of the benefit can be found in the impact of the packaging technology on other parts of the supply chain, so the scope of the cost analysis extends beyond just the cost of the package. This approach can be used for analysis of any CSP stacking technology.
Energetics of Formation and Oxidation of Microporous Calcium Aluminates: A New Class of Electrides and Ionic Conductors. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.