gebhart/patrepeval huggingface dataset:
Effect of Donor Age and Donor Relatedness on Time to Allogeneic Hematopoietic Cell Transplantation in Acute Leukemia (2018)

Relapse after allogeneic hematopoietic cell transplantation (HCT) for acute leukemia can be reduced when pursued early after first complete remission. The impact of donor age and donor relatedness on the time from diagnosis to transplant in patients with acute leukemia was examined to clarify the design of future prospective studies that can address optimal donor choice. Files of 100 consecutive patients undergoing transplantation for leukemia were reviewed. Recipients of related donors (RDs) and unrelated donors (UDs) were not significantly different in terms of recipient gender, age, underlying diagnosis, disease risk index, graft source, or donor HLA match. UDs were significantly younger than RDs (median age, 29 versus 51, P < .001). Multivariate linear regression revealed that when controlling for age of donor and recipient, the time from diagnosis to transplant was 35% longer with UDs compared with RDs (P = .018). No significant correlation was observed between donor and recipient age on length of time to transplant (P = .134 and P = .850, respectively), when controlling for other variables. The steps in UD procurement that contribute most to the longer time to transplant relate to activating the donor workup and scheduling the donor workup before cell collection. Understanding sources of delay in the transplant process will help transplant centers and UD registries reduce the time to transplant for patients with acute leukemia and will provide necessary insight for the design of prospective controlled studies that can address optimal donor choice.
ChemInform Abstract: Olefin Epoxidation by Methyltrioxorhenium: A Density Functional Study on Energetics and Mechanisms. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Magnetic field-free measurements of the total cross sections for positron–neon and positron–argon scattering (2012)

Magnetic field-free measurements of the total cross sections for positron-neon and positron-argon scattering have been performed using an electrostatic high-brightness slow positron beam apparatus.
Learned Uncertainty Calibration for Visual Inertial Localization (2021)

The widely-used Extended Kalman Filter (EKF) provides a straightforward recipe to estimate the mean and covariance of the state given all past measurements in a causal and recursive fashion. For a wide variety of applications, the EKF is known to produce accurate estimates of the mean and typically inaccurate estimates of the covariance. For applications in visual inertial localization, we show that inaccuracies in the covariance estimates are systematic, i.e. it is possible to learn a nonlinear map from the empirical ground truth to the estimated one. This is demonstrated on both a standard EKF in simulation and a Visual Inertial Odometry system on real-world data.
Glutathione disulfide and S‐nitrosoglutathione detoxification by Mycobacteriumtuberculosis thioredoxin system (2009)

Mycobacterium tuberculosis resides within alveolar macrophages. These phagocytes produce reactive nitrogen and oxygen intermediates to combat the invading pathogens. The macrophage glutathione (GSH) pool reduces nitric oxide (NO) to S-nitrosoglutathione (GSNO). Both glutathione disulfide (GSSG) and GSNO possess mycobactericidal activities in vitro. In this study we demonstrate that M. tuberculosis thioredoxin system, comprises of thioredoxin reductase B2 and thioredoxin C reduces the oxidized form of the intracellular mycothiol (MSSM) and is able to efficiently reduce GSSG and GSNO in vitro. Our study suggests that the thioredoxin system provide a general reduction mechanism to cope with oxidative stress associated with the microbe's metabolism as well as to detoxify xenobiotics produced by the host.
Modeling muscle regeneration in RNA toxicity mice (2021)

RNA toxicity underlies the pathogenesis of disorders such as myotonic dystrophy type 1 (DM1). Muscular dystrophy is a key element of the pathology of DM1. The means by which RNA toxicity causes muscular dystrophy in DM1 is unclear. Here, we have used the DM200 mouse model of RNA toxicity due to the expression of a mutant DMPK 3'UTR mRNA to model the effects of RNA toxicity on muscle regeneration. Using a BaCl2-induced damage model, we find that RNA toxicity leads to decreased expression of PAX7, and decreased numbers of satellite cells, the stem cells of adult skeletal muscle (also known as MuSCs). This is associated with a delay in regenerative response, a lack of muscle fiber maturation and an inability to maintain a normal number of satellite cells. Repeated muscle damage also elicited key aspects of muscular dystrophy, including fat droplet deposition and increased fibrosis, and the results represent one of the first times to model these classic markers of dystrophic changes in the skeletal muscles of a mouse model of RNA toxicity. Using a ligand-conjugated antisense (LICA) oligonucleotide ASO targeting DMPK sequences for the first time in a mouse model of RNA toxicity in DM1, we find that treatment with IONIS 877864, which targets the DMPK 3'UTR mRNA, is efficacious in correcting the defects in regenerative response and the reductions in satellite cell numbers caused by RNA toxicity. These results demonstrate the possibilities for therapeutic interventions to mitigate the muscular dystrophy associated with RNA toxicity in DM1.
Electrodeposition of Ni‐Zn Alloy: II . Electrocrystallization of Zn, Ni, and Ni‐Zn alloy (1993)

The initial stages of the electrodeposition of nickel, zinc, and nickel‐zinc alloy were investigated by nucleation analysis. A novel deconvolution technique was applied to obtain the individual chronoamperometry of each species and elucidate the nucleation and growth mechanism of nickel‐zinc alloy deposition. In agreement with earlier conclusions (part I of this study), codeposition of hydrogen and nickel occurs in the initial stage of deposition. Adsorption and evolution of hydrogen are significant and cause the enhancement of nickel content. From the deconvoluted chronoamperograms of nickel‐zinc deposition, we see that the nucleation and growth mechanism of the alloy is similar to that of the pure metals (i.e., nickel or zinc). This similarity implies a weak interaction between nickel and zinc nuclei in the initial stages of deposition.
Spectroscopy of the neutron-deficient nucleus 167Os91 (2009)

Excited states of the nucleus 167 Os have been populated by the reaction 92 Mo( 78 Kr, 2pn). The JUROGAM γ-ray detector array has been used in conjunction with the RITU gas-filled separator and the GREAT spectrometer to observe prompt γ rays in coincidence with recoiling fusion-evaporation residues and their subsequent decay by α particle emission. By correlating prompt γ radiation with the characteristic α radioactivity of 167 Os, it has been possible to extend the level scheme for this nucleus significantly. In particular, an extension of the yrast band and four previously unobserved bands are reported. In addition, the recoil distance Doppler-shift method was used to determine a lifetime of τ = 20(4) ps for The I π = 17/2 + state in 167 Os. Hence, the level of collectivity and magnitude of deformation of the low spin yrast band of this nucleus is established.
Relationship among neuroimaging indices of cerebral health during normal aging (2007)

Abstract Sensitive measures of brain aging show great promise for gauging factors that affect aging and degenerative processes, such as risk genes or therapy. Here we examined age‐related trends for three indices of cerebral health: gyral gray matter (GM) thickness, dilation of sulcal spaces with CSF, and the volume of T2‐hyperintense white matter (HWM) lesions. The study involved 31 healthy adults age 57–82 years old. Measurements of average GM thickness, average sulcal span and HWM volume were performed using high‐resolution 3D T1‐ and T2‐weighted brain MR images. Age‐related trends for the three cerebral health indices were consistent with previously published work though the analysis of their covariance led to a previously unreported relationship. Simultaneous multiple regression found that dilation of cortical sulci were primarily ( t = 2.59, P &lt; 0.01) related to the increases in HWM volume and secondarily related ( t = −2.51, P &lt; 0.01) to the reductions of the cortical GM thickness. The are‐corrected correlation between reduction in GM thickness and increases in HWM volume, was not significant ( P = 0.34). These findings are of interest in designing quantitative measures of brain aging for monitoring individual patients and in large‐scale clinical trials. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.
Economic lot scheduling of fully loaded processes with external setups (1991)

Without restricting the class of permissible schedules, we derive optimal schedules for economic lot scheduling problems that are fully loaded, have external setups, and have only two products. The fully loaded condition accurately represents certain types of bottlenecks. We show that the optimal schedule must have the Wagner-Whitin property. We also develop a measure of aggregate inventory, derive an optimal steady-state aggregate inventory policy, and provide conditions under which the aggregate inventory level of an optimal schedule must approach a steady state. By restricting the class of permissible schedules to rotation cycle schedules, we extend these results to more than two products.
<title>Proteus: a reconfigurable computational network for computer vision</title> (1992)

The Proteus architecture is a highly parallel MIMD, multiple instruction, multiple-data machine, optimized for large granularity tasks such as machine vision and image processing The system can achieve 20 Giga-flops (80 Giga-flops peak). It accepts data via multiple serial links at a rate of up to 640 megabytes/second. The system employs a hierarchical reconfigurable interconnection network with the highest level being a circuit switched Enhanced Hypercube serial interconnection network for internal data transfers. The system is designed to use 256 to 1,024 RISC processors. The processors use one megabyte external Read/Write Allocating Caches for reduced multiprocessor contention. The system detects, locates, and replaces faulty subsystems using redundant hardware to facilitate fault tolerance. The parallelism is directly controllable through an advanced software system for partitioning, scheduling, and development. System software includes a translator for the INSIGHT language, a parallel debugger, low and high level simulators, and a message passing system for all control needs. Image processing application software includes a variety of point operators neighborhood, operators, convolution, and the mathematical morphology operations of binary and gray scale dilation, erosion, opening, and closing.
T‐Lymphocytes Expressing CC Chemokine Receptor‐5 Are Increased in Frail Older Adults (2008)

These initial results suggest an expansion of the CCR5(+) T-cell subpopulation in frailty. They provide a basis for further characterization of CCR5(+) T-cells and their role in frailty, with potential therapeutic implications.
Determinants Of Participation Behavior Of Limited Resource Farmers In Conservation Reserve Program In Alabama (2003)

This study investigated factors that affect participation behavior of limited resource farmers (LRF) in Conservation Reserve Program (CRP) in Alabama. A binary logit model was employed to analyze data obtained from 611 respondents. Results indicated that males, part-time occupation, total acres, participation in non-conservation related programs, direct method of receiving CRP information, and respondents' interest in receiving CRP information, were strong predictors of participation in the CRP. Key words: Limited resource, CRP, minorities, participation behavior
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma (2020)

B-cell receptor (BCR) signaling pathway inhibitors (including Bruton’s tyrosine kinase [BTK] inhibitors, and phosphatidylinositol-3 kinase inhibitors [PI3Ki]) have shown clinical efficacy in non-Hodgkin lymphoma (NHL). However, responses to these agents have been limited in depth and duration. This may be due to resistance to PI3Kδ and BTK inhibitors as monotherapy. The emergence of resistant clones may be addressed by combining these 2 classes of drugs. Furthermore, tolerability of these drug classes has been a concern. Combination therapy using lower doses of one or more classes of inhibitor may address some limitations.
On OFDMA Resource Allocation and Wavelength Assignment in OFDMA-Based WDM Radio-Over-Fiber Picocellular Networks (2011)

This paper addresses the orthogonal frequency-division multiple access (OFDMA) resource allocation and wavelength assignment problems in wavelength-division multiplexing (WDM) radio-over-fiber picocellular networks with OFDMA as the wireless modulation and access scheme. We consider the case that the number of WDM wavelengths is limited in which one wavelength is shared among multiple picocells. The set of picocells sharing the same wavelength is referred to as a nanocell in this paper. Since picocells in the same nanocell cannot be allocated with OFDMA resource block (RB) of the same frequency at a time, the intra-nanocell interference is eliminated. However, picocells in different nanocells may be allocated with OFDMA RBs of the same frequency at a time, thus posing interference to each other. To minimize the inter-nanocell interference, OFDMA RBs of the same frequency are assigned to picocells which pose the least interference to each other. However, this may result in some picocells being allocated with a large number of OFDMA RBs, leading to the limited power share received by each OFDMA RB because of the power constraint of the picocell. To minimize the inter-nanocell interference with consideration of the power constraints of picocells, we recast the OFDMA resource allocation and wavelength assignment problems into graph problems, and then propose corresponding solutions.
Ductal Carcinoma In Situ: Challenges, Opportunities, and Uncharted Waters (2012)

Ductal carcinoma in situ (DCIS) is a heterogeneous group of diseases that differ in biology and clinical behavior. Until 1980, DCIS represented less than 1% of all breast cancer cases. With the increased utilization of mammography, DCIS now accounts for 15% to 25% of newly diagnosed breast cancer cases in the United States. Although our ability to detect DCIS has radically improved, our understanding of the pathophysiology and factors involved in its progression to invasive carcinoma is still poorly defined. In many patients, DCIS will never progress to invasive breast cancer and these women are overtreated. In contrast, some DCIS cases are clinically aggressive and the women may be undertreated. We are able to define some of the predictors of aggressive DCIS compared with DCIS of low malignant potential. However, our ability to risk-stratify DCIS is still in its infancy. Clinical risk factors that predict aggressive disease and increased risk of local recurrence include young age at diagnosis, large lesion size, high nuclear grade, comedo necrosis, and involved margins. Treatment factors such as wider surgical margins and radiation therapy reduce the risk of local recurrence. DCIS represents a key intermediate in the stepwise progression to malignancy, but not all aggressive breast cancers appear to have a DCIS intermediate, notably within triple-negative breast cancer. Ongoing studies of the genetic and epigenetic alterations in precancerous breast lesions (atypia and DCIS) as well as the breast microenvironment are important for developing effective early detection and individualized targeted prevention.
Analysis and Simulation of Adjacent Service Interference to Vehicle-Equipped Satellite Digital Radio Receivers From Cellular Mobile Terminals (2010)

This paper provides detailed analysis and simulation for explol'ing the impact of out-of-band emissions (OOBE) of adjacent wireless services to the Sirius XM digital satellite radio service. Based on an extensive analysis of interference from vehicles with mobile cellular users in realistic roadway conditions, we propose proper methods for determining out of band emission spectral masks that should be used by new WCS cellular subscriber transmitters. in the 2.3 GHz band. Analysis for roadway and propagation conditions in various US cities resulted in the suggested masks. This work presents the first simulation of its ldnd and offers approaches that federal regulators may use to determine spectral masks that allow harmonious co-existence of existing mobile radio listeners with new cellular and fixed broadband mobile services in adjacent spectrum bands.
Democratizing Chatbot Debugging: A Computational Framework for Evaluating and Explaining Inappropriate Chatbot Responses (2023)

Evaluating and understanding the inappropriateness of chatbot behaviors can be challenging, particularly for chatbot designers without technical backgrounds. To democratize the debugging process of chatbot misbehaviors for non-technical designers, we propose a framework that leverages dialogue act (DA) modeling to automate the evaluation and explanation of chatbot response inappropriateness. The framework first produces characterizations of context-aware DAs based on discourse analysis theory and real-world human-chatbot transcripts. It then automatically extracts features to identify the appropriateness level of a response and can explain the causes of the inappropriate response by examining the DA mismatch between the response and its conversational context. Using interview chatbots as a testbed, our framework achieves comparable classification accuracy with higher explainability and fewer computational resources than the deep learning baseline, making it the first step in utilizing DAs for chatbot response appropriateness evaluation and explanation.
In-situ growth of superconducting SmO1−xFxFeAs thin films by pulsed laser deposition (2016)

Oxypnictide thin film growth by pulsed laser deposition (PLD) is one of many insufficiently resolved issues in the research of iron-based superconductors. Here we report on the successful realization of superconducting SmO<sub>1-x</sub>F<sub>x</sub>FeAs oxypnictide thin film growth by in-situ PLD on CaF<sub>2</sub> (fluorite) substrates. CaF<sub>2</sub> acts as fluorine supplier by diffusion and thus enables superconducting oxypnictide thin film growth by PLD. Films are grown heteroepitaxially and characteristically have a broad resistive normal-to-superconducting transition. Best films have onset transition temperatures around 40 K. The proposed in-situ PLD film growth offers an alternative and cheap route for the fabrication of iron oxypnictides. PLD becomes now an additional option for iron oxypnictide synthesis.
A discontinuity detector for building extraction from Digital Elevation Models by stochastic geometry (2004)

This work presents a framework to use stochastic geometry for auto-matic building extraction from different kinds of Digital Elevation Models (DEM). The goal is to extract some vectorial information from a DEM in order to ease precise 3 dimensional reconstruction. Using a spatial point process framework, we model cities as config-urations of unknown number of rectangles. An energy is defined, which takes into account both a low level information provided by the altimetry of the scene, and some geometric knowledge on the location of buildings in towns. The estimation is done by minimiz-ing an energy using simulated annealing. We present results on real data provided by IGN (French National Geographic Institute) con-sisting of laser and optical DEMs. 1.
Abstract 10689: Vascular Senescence and Potential Mechanisms for Increased Susceptibility to Cardiovascular Diseases (2011)

Purpose of the study: Aging is a primary non-modifiable risk factor for cardiovascular diseases including atherosclerosis and hypertension. Several studies have shown complex bi-directional shifts ...
The sensitivity of the ice-nucleating ability of minerals to heat and the implications for the heat test for biological ice nucleators (2021)

Abstract. Ice-nucleating particles (INPs) are atmospheric aerosol particles that can strongly influence the radiative properties and precipitation onset in mixed-phase clouds by triggering ice formation in supercooled cloud water droplets. The ability to distinguish between INPs of mineral and biological origin in samples collected from the environment is needed to better understand their distribution and sources, but this is challenging. A common method for assessing the relative contributions of mineral and biogenic INPs in samples collected from the environment (e.g., aerosol, rainwater, soil) is to determine the ice-nucleating ability (INA) before and after heating, where heat is expected to denature proteins associated with biological ice nucleants. The key assumption is that the ice nucleation sites of biological origin are denatured by heat, while those associated with mineral surfaces remain unaffected; we test this assumption here. We exposed atmospherically relevant mineral samples to wet heat (INP suspensions warmed to above 90 °C) or dry heat (dry samples heated to 250 °C) and assessed the effects on their immersion mode INA using a droplet freezing assay. K-feldspar, thought to be the dominant mineral-based atmospheric INP type where present, was not significantly affected by wet heating, while quartz, plagioclase feldspars and Arizona test Dust (ATD) lost INA when heated in this mode. We argue that these reductions in INA in the aqueous phase result from direct alteration of the mineral particle surfaces by heat treatment rather than from biological or organic contamination. We hypothesise that degradation of active sites by dissolution of mineral surfaces is the mechanism in all cases due to the correlation between mineral INA deactivation magnitudes and their dissolution rates. Dry heating produced minor but repeatable deactivations in K-feldspar particles but was generally less likely to deactivate minerals compared to wet heating. We also heat tested proteinaceous and non-proteinaceous biogenic INP proxy materials and found that non-proteinaceous samples (cellulose and pollen) were relatively heat resistant. In contrast, the proteinaceous ice-nucleating samples were highly sensitive to wet and dry heat, as expected, although their activity remained non-negligible after heating. We conclude that, while INP heat tests have the potential to produce false positives, i.e., deactivation of a mineral INA that could be misconstrued as the presence of biogenic INPs, they are still a valid method for qualitatively detecting proteinaceous biogenic INP in ambient samples, so long as the mineral-based INA is controlled by K-feldspar.
Study of the mechanical behavior of welded tubular joints for a better prediction of their life under thermo mechanical fatigue (2007)

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