gebhart/patrepeval huggingface dataset:
Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks (2003)

Chronic lead exposure has been associated with elevated blood pressure in epidemiological studies. It is not known whether the previously observed relation between blood lead and hypertension persists after significant reductions have been made in environmental lead contamination. We examined the relation between blood lead levels and blood pressure in a representative sample of 14 952 whites and blacks aged 18 years or older who participated in the Third National Health and Nutrition Examination Survey. Blood lead was measured by atomic absorption spectrophotometry and blood pressure by standard sphygmomanometry. Mean blood lead levels were significantly higher for black men and women (5.4 and 3.4 microg/dL, respectively) compared with white men and women (4.4 and 3.0 microg/dL, respectively). After multivariate adjustment for important covariables, each standard deviation higher blood lead (3.3 microg/dL) was associated with a 0.82 (95% confidence interval [CI], 0.19 to 1.44) mm Hg and a 1.55 (95% CI, 0.47 to 2.64) mm Hg higher systolic blood pressure among black men and women, respectively. In contrast, blood lead level was not associated with blood pressure among white men or women. The multivariate-adjusted odds ratio (95% CI) of hypertension associated with a 1-SD higher level of blood lead was 1.08 (95% CI, 0.99 to 1.19) for black men and 1.39 (95% CI, 1.21 to 1.61) for black women. These findings suggest that increased levels of blood lead remain an important environmental risk factor for elevated blood pressure in blacks.
rapmad: Robust analysis of peptide microarray data (2011)

rapmad allows the robust and sensitive, automated analysis of high-throughput peptide array data. The rapmad R-package as well as the data sets are available from http://www.tron-mz.de/compmed.
Collaborative resource exchanges for peer-to-peer video streaming over wireless mesh networks (2007)

Peer-to-peer collaboration paradigms fundamentally change the passive way wireless stations currently adapt their transmission strategies to match available resources, by enabling them to proactively influence system dynamics through exchange of information and resources. In this paper, we focus on delay-sensitive multimedia transmission among multiple peers over wireless multi-hop enterprise mesh networks. We propose a distributed and efficient framework for resource exchanges that enables peers to collaboratively distribute available wireless resources among themselves based on their quality of service requirements, the underlying channel conditions, and network topology. The resource exchanges are enabled by the scalable coding of the video content and the design of cross-layer optimization strategies, which allow efficient adaptation to varying channel conditions and available resources. We compare our designed low complexity distributed resource exchange algorithms against an optimal centralized resource management scheme and show how their performance varies with the level of collaboration among the peers. We measure system utility in terms of the multimedia quality and show that collaborative approaches achieve ~50% improvement over non-collaborative approaches. Additionally, our distributed algorithms perform within 10% system utility of a centralized optimal resource management scheme. Finally, we observe 2-5 dB improvement in decoded PSNR for each peer due to the deployed cross-layer strategy
Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy. (1986)

Monocyte-derived macrophages from 14 patients with lepromatous leprosy respond to rIFN-gamma with an enhanced secretion of H2O2 in a fashion similar to that of cells obtained from normal donors. The activation is not dependent on the cutaneous bacterial index, the length of treatment, or the stage and activity of the disease. H2O2 release can be triggered in these cells both by phorbol myristate acetate and by intact irradiated Mycobacterium leprae. Uptake of M. leprae by both normal donors' and patients' macrophages is proportional to the number of bacilli added. Prior ingestion of M. leprae does not interfere with the ability of macrophages to respond to IFN-gamma by the production of oxygen intermediates. We conclude that the immune defect in lepromatous leprosy probably results from a lack of response to M. leprae by the patients' T cells rather than an inability of mononuclear phagocytes to respond to IFN-gamma.
Low-power high-speed 1-V LSI using a 0.25-μm MTCMOS/SIMOX technique (2002)

A 1-V low-power high-speed circuit technique has been developed using a multi-threshold CMOS (MTCMOS) scheme with separation by implanted oxygen (SIMOX) SOI technology. The combination of MTCMOS and SIMOX results in 60%-faster operation and 80%-lower power consumption, compared to a conventional CMOS/bulk circuit. In order to reduce the power of not only the circuit but also the system, we propose an interface scheme that is compatible with conventional LSIs or transfers signal at high speed and low power. A standard-cell-based MPU was fabricated using 0.25-/spl mu/m MTCMOS/SIMOX. The maximum operating frequency is over 100 MHz and the energy consumption is 0.5 mW/MHz at the supply voltage of 1.0 V.
30 Gbit/s InP DHBT 2:1 selector-driver IC for external laser modulation (1997)

A high speed 2:1 selector-driver IC developed for external laser modulation is presented. The IC delivers a maximum output voltage swing of 2.2 Vpp at 30 Gbit/s on a 50Ω load. The circuit was fabricated in a laboratory InP/InGaAs double heterojunction bipolar transistor technology with Ft ≃ 56 GHz and Fmax ≃ 43 GHz.
Variations in the Optical Characteristics of 200 μm and 250 μm Coated Multicore Fibres Owing to Cabling (2021)

The optical characteristics of cabled four-core multicore fibres (4CFs) with 200 μm and standard 250 μm coating diameters are compared, and are found to be identical. Effective bending diameter of 4CFs in a cable is estimated to be small, which leads to low crosstalk.
One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine (2017)

In Africa around 625 000 mortalities per annum (20% of HIV/AIDS related deaths) are due to the affects of the Cryptococcal meningitis (CM) fungal infection. Recently, the World Health Organisation (WHO) and the Infectious Disease Society of America (IDSA) recommended that the first line treatment for CM is a combination of amphotericin B and flucytosine, both now WHO Essential Medicines. However, flucytosine is not even registered for use in any African nation due, in part, to its relatively high cost of manufacture and lack of generic manufacturers. Currently, flucytosine is manufactured by an expensive four-step manufacturing process. Here we report a one-step continuous flow process involving the reaction of inexpensive cytosine with fluorine gas using stainless steel tubular laboratory and pilot-scale silicon carbide reactor devices which is readily scaleable to a manufacturing process with a low initial capital expenditure.
SILDENAFIL INHIBITS PHOSPHODIESTERASE TYPE 5 IN HUMAN CLITORAL CORPUS CAVERNOSUM SMOOTH MUSCLE (1999)

Abstract Phosphodiesterases play an important physiological role by regulating the intracellular levels of cyclic nucleotides. In this study, we investigated the kinetic parameters of inhibition of phosphodiesterase (PDE) type 5 (EC 3.1.4.35, 3′,5′-cyclic GMP phosphodiesterase) by a novel, high-affinity, selective PDE type 5 inhibitor, sildenafil, in intact cells and in soluble extracts of human clitoral corpus cavernosum smooth muscle cells. Sildenafil inhibited cGMP hydrolysis in the crude extract (Ki= 7.2 ± 2.7) and in partially purified preparations (Ki= 9 nM) in a competitive manner, as determined by Dixon plots. Sildenafil was a more effective PDE type 5 inhibitor than zaprinast (Ki= 400.0 ± 76.4 nM, crude extracts; 250 nM, partially purified). Stimulation of intracellular cGMP synthesis by the nitric oxide donor sodium nitroprusside resulted in a 3.3- and 2.9-fold increase in cGMP concentration in the presence of sildenafil or zaprinast, respectively, compared to sodium nitroprusside treatment alone in intact cells at physiological temperatures. These observations suggest that human clitoral corpus cavernosum smooth muscle tone may be regulated by the synthesis and release of nitric oxide and that this pathway is dependent on PDE type 5 activity.
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade (2020)

Abstract While neoantigen-specific tumor infiltrating lymphocytes (TIL) can be derived from in antigen-expressing tumors, their adoptive transfer fails to consistently elicit durable tumor regression. There has been much focus on the role of activation/exhaustion markers such as PD1, CD39 and TOX in TIL senescence. We found these markers were inversely expressed to Cytokine-Induced SH2 protein (CISH), a negative regulator of TCR signaling and tumor immunity in mice. To evaluate the physiological role of CISH in human TIL we developed a high-efficiency CRIPSR-based method to knock out CISH in fully mature TIL. CISH KO resulted in increased T cell receptor (TCR) avidity, tumor cytolysis and neoantigen recognition. CISH expression in the tumor resections correlated with TIL inactivity against p53 hotspot mutations and CISH KO in TIL unmasked reactivity against these universal neoantigens. While CISH KO resulted in T cell hyperactivation and expansion it did not alter maturation, perhaps by preferential PLCγ-1 and not AKT inhibition. Lastly, CISH KO in T cells increased PD1 expression and the adoptive transfer of Cish KO T cells synergistically combines with PD1 antibody blockade resulting in durable tumor regression and survival in a preclinical animal model. These data offer new insights into the regulation of neoantigen recognition, expression of activation/exhaustion markers, and functional/maturation signals in tumor-specific T cells.
The evolution of the infrared emission from the Type II supernova 1980k in NGC 6946 - The dust formation model (1983)

The paper presents 1-4 micron photometry of supernova 1980 k in NGC 6946 obtained over a period of 1 year following the outburst. During the period between 1980 November 1 and December 19, the infrared emission probably originated from the extended atmosphere of the expanding star. The JHKL colors and a 1.3-2.6-micron spectrum observed during this period correspond to those of a blackbody with an average temperature of about 5000 K. Observations around 1981 May 31 showed that the supernova developed an infrared excess after 1980 December. This infrared excess persisted through 1981 October and is consistent with the appearance of thermal emission from about 700 to 900 K dust in addition to a hotter photosphere. The similarity of this behavior to that of the infrared evolution of some novae suggests that dust formation may be occurring in the supernova ejecta. The hypothesis, that the emission arises from preexisting grains in a circumstellar shell which are heated by the supernova outburst, is also consistent with the data.
Modeling of a multi-megawatt grid connected PV system with integrated batteries (2016)

The multi-megawatt grid connected photovoltaic (PV) system studied in the paper includes parallel arrays and power electronic units, each with their own DC-DC and DC-AC converters. In one configuration, the DC-AC converters of adjacent parallel sections are connected in cascade, in order to effectively operate as a multilevel inverter, thereby reducing the filtering requirements. Grid voltage oriented control is employed for inverters and a battery is incorporated for energy storage and performance improvement. Modeling is performed with the PSCAD/EMTDC software, such that both the power electronics components, controls and subsystem aspects, and the electric grid power system issues, can be studied during steady-state and transient operation. The system simulation is demonstrated on a modified IEEE 14-bus test case.
A Diffusion-Corrected Sigma Algorithm for a Four-Detector Pulsed-Neutron Logging Tool (2018)

Abstract Sigma logging is a proven method for determining oil/water saturation behind casing. In this paper, we present a new, diffusion-corrected, sigma algorithm for a four-detector pulsed-neutron logging tool. Since the diffusion effect is inversely related to the distance between source and detector, there is an advantage in having multiple detectors at varying distances from the source. We will show how we use this advantage to design a diffusion-corrected sigma algorithm, and will verify the results using lab data, MCNP simulation, and field logs. Furthermore, we will discuss our use of a dual-exponential fit to cleanly separate the borehole decay from the formation decay. We will show that this approach works well, and can provide a certain advantage relative to the "moments method".
Novel antifungal antibiotics maniwamycins A and B. II. Structure determination. (1989)

The structures of the new azoxy antibiotics maniwamycins A and B have been determined by means of spectral analyses and chemical studies.
Kinetic and Mechanistic Parameters of Laccase Catalyzed Direct Electrochemical Oxygen Reduction Reaction (2011)

This article presents the kinetic studies of oxygen reduction by one of the most important multicopper oxidases (fungal laccase) using the classic tool of electrochemistry: rotating ring-disk electrode (RRDE). Laccase was immobilized on a multiwalled carbon nanotube (MWNT) modified inert disk electrode using 1-pyrenebutanoic acid succinimidyl ester (PBSE), as a tethering agent. The conditions for laccase immobilization on MWNT were optimized to prepare a highly active composite electro-catalyst for O2 reduction. The mechanistic as well as kinetic parameters such as Tafel slopes, number of electrons transferred, electrochemical rate constants (for heterogeneous charge transfer) and electron transfer rate constant were calculated from the RRDE experiment results. The Tafel slope obtained was close to the value of that of ideal four-electron reduction of O2 to water indicating a highly active laccase in the tethered composite. The RRDE results also suggested the presence of intermediate steps in the oxygen reduction reaction. A model pathway for O2 reduction reaction at the laccase composite modified electrode was postulated, and rate constants for individual reactions in the pathway were calculated. The rate constant for four-electron O2 reduction was determined to be 1.46 × 10–3 mol s–1, indicating excellent electro-catalytic activity of the laccase-MWNT composite catalyst.
Constitutive overexpression of periostin delays wound healing in mouse skin (2018)

Periostin is a matricellular protein involved in development, maintenance, and regulation of tissues and organs via by binding to cell surface integrin receptors. Pathologically, periostin plays an important role in the process of wound healing: as a deficiency of the Postn gene delays wound closure and periostin is consistently up-regulated in response to injury and skin diseases. However, the functional role of elevated periostin in the process of wound healing has not been tested. In this study, we generated Postn-transgenic mice under the control of the CAG promoter/enhancer to investigate the effects of constitutive overexpression of full length periostin during its pathophysiological roles. Transgenic mice showed significant overexpression of periostin in skin, lung, and heart, but no morphological changes were observed. However, when these transgenic mice were injured, periostin overexpression delayed the closure of excisional wounds. Expression of IL-1β and TNFα, pro-inflammatory cytokines important for wound healing, was significantly decreased in the transgenic mice, prior to delayed healing. Infiltration of neutrophils and macrophages, the main sources of IL-1β and TNFα, was also down-regulated in the transgenic wound sites. From these data, we conclude that enforced expression of periostin delays wound closure due to reduced infiltration of neutrophils and macrophages followed by down-regulation of IL-1β and TNFα expression. This suggests that regulated spatiotemporal expression of periostin is important for efficient wound healing and that constitutive periostin overexpression interrupts the normal process of wound closure.
INITIAL EXPERIENCE WITH THE TRANSURETHRAL SELF-DETACHABLE BALLOON SYSTEM FOR URINARY INCONTINENCE IN PEDIATRIC PATIENTS (2000)

A new endoscopic technique to treat urinary incontinence in children using a self-detachable balloon device was studied.The study includes 11 patients with a mean age of 14.6 years and all of whom had intrinsic sphincter deficiency due to myelomeningocele in 9, spinal artery bleed in 1 and cloacal exstrophy in 1. All patients were on clean intermittent catheterization preoperatively and postoperatively. Endoscopic balloon treatment was performed on an outpatient basis. A mean of 5 balloons (range 2 to 8) were placed per patient. All patients underwent formal urodynamic study preoperatively and at 6 weeks and 6 months following balloon placement.Of the 9 patients without prior bladder neck surgery 7 had improvement in urodynamic parameters, including urethral pressure profile in all 7 and functional bladder capacity in 6, 4 were markedly improved clinically and 2 were dry. Two patients with prior bladder neck surgery were clinically unchanged following balloon placement, although 1 had urodynamic improvement.Our initial experience with the transurethral self-detachable balloon system as a minimally invasive outpatient procedure to treat urinary incontinence in children has been encouraging. To date this procedure appears most applicable to the patient who has not undergone surgery and has a neurogenic etiology for urinary incontinence.
A Data Gathering Scheme in Wireless Sensor Networks Based on Synchronization of Chaotic Spiking Oscillator Networks (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hidehiro Nakano, Akihide Utani, Arata Miyauchi, Hisao Yamamoto; A Data Gathering Scheme in Wireless Sensor Networks Based on Synchronization of Chaotic Spiking Oscillator Networks. AIP Conf. Proc. 19 April 2011; 1339 (1): 56–66. https://doi.org/10.1063/1.3574844 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
The effect of Rhodiola kirilowii extracts on pigs' blood leukocytes metabolic (RBA) and proliferative (LPS) activity, and on the bacterial infection and blood leukocytes number in mice (2012)

Rhodiola kirilowii roots and rhizomes extracts are used in Asiatic medicine independently of their adaptogenic properties also as antimicrobial and anti-inflammatory drugs. The aim of this work was to study the in vitro modulatory potential of aqueous and hydro-alcoholic extracts of under-ground parts of Rhodiola kirilowii (RK) on respiratory burst activity (RBA) and on the proliferative response to lipopolysaccharide (LPS) in blood leukocyte cultures of pigs. Both extracts in concentration up to 10 μg/ml stimulated this parameter. Higher concentrations of RK extracts were ineffective (20 μg/ml) or inhibitory (50 μg/ml). Further, the effect of feeding mice with Rhodiola kirilowi aqueous (RKW) and 50% hydro-alcoholic (RKA) extracts on Pseudomonas aeruginosa infection was studied. It was found that the infection intensity was significantly lower, in comparison to the control, when mice obtained daily, for 7 days before P. aeruginosa i.p. inoculation, 0.4 mg of RKA or RKW extract. Accordingly, feeding mice with both extracts for 7 days, in 0.1 and 0.2 mg (RKW) and 0.1 mg (RKA) daily doses, increased blood leukocytes (both lymphocytes and granulocytes) number.
Whole-genome sequencing to improve sarcoma diagnosis and patient care. (2021)

11540 Background: With more than 70 different histological subtypes, accurate classification sarcomas is challenging. Although pathognomonic genetic events aid accurate classification, large-scale molecular profiling is generally not incorporated in regular diagnostic workflows for sarcoma patients. We hypothesized that whole genome sequencing (WGS) optimizes clinical care of sarcoma patients by detection of pathognomonic and actionable variants, and of underlying hereditary conditions. Methods: WGS of tumor and germline DNA was incorporated in the diagnostic work-up of 83 patients with a (presumed) sarcoma as part of the WIDE (Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient) study in a tertiary referral center. WGS results were reported back to the pathologist and treating clinician. Clinical follow-up data were collected prospectively to assess impact of WGS on clinical decision making. Results: WGS analysis had impact on multiple levels. First, in 14% of cases (12/83 patients), the genomic profile led to a revision of the diagnosis (table). All patients had undergone multiple diagnostic procedures (mean number: 4) and pathologist assessments (mean: 6) before WGS analysis was performed. Secondly, actionable biomarkers with therapeutic potential were detected for 36/83 patients and finally, 8 pathogenic germline variants were present. Taken together, WGS had implications for clinical decision making in 52% of patients with (presumed) sarcomas. Conclusions: WGS is an important extension of the diagnostic arsenal of pathologists and has contributed to change of care in 52% of patients with sarcomas. Given the diagnostic complexity and high unmet need for new treatment opportunities in sarcomas we advocate the use of WGS for sarcoma patients early in the disease course. Clinical trial information: NL68609.031.18. [Table: see text]
Characteristics of the Interaction between Thrombin Exosite1 and the Sequence 269-297 of Platelet Glycoprotein Ibα (1998)

The interaction between GPIb and thrombin promotes platelet activation elicited via the hydrolysis of the thrombin receptor and involves structures located on the segment 238-290 within the N-terminal domain of GPIbalpha and the positively charged exosite 1 on thrombin. We have investigated the ability of peptides derived from the 269-287 sequence of GPIbalpha to interact with thrombin. Three peptides were synthesized, including Ibalpha 269-287 and two scrambled peptides R1 and R2 which are comparable to Ibalpha 269-287 with regards to their content and distribution of anionic residues. However, R2 differs from both Ibalpha 269-287 and R1 by the shifting of one proline from a central position to the N-terminus. By chemical cross-linking, we observed the formation of a complex between 125I-Ibalpha 269-287 and alpha-thrombin that was inhibited by hirudin, the C-terminal peptide of hirudin, sodium pyrophosphate but not by heparin. The complex did not form when gamma-thrombin was substituted for alpha-thrombin. Ibalpha 269-287 produced only slight changes in thrombin amidolytic activity and inhibited thrombin binding to fibrin. R1 and R2 also formed complexes with alpha-thrombin, modified slightly its catalytic activity and inhibited its binding to fibrin. Peptides Ibalpha 269-287 and R1 inhibited platelet aggregation and secretion induced by low thrombin concentrations whereas R2 was without effect. Our results indicate that Ibalpha 269-287 interacts with thrombin exosite 1 via mainly electrostatic interactions, which explains why the scrambled peptides also interact with exosite 1. Nevertheless, the lack of effect of R2 on thrombin-induced platelet activation suggests that proline 280 is important for thrombin interaction with GPIb.