gebhart/patrepeval huggingface dataset:
DL-MOTIF: Deep Learning Based Motion Transformation Integrated Forward-Fourier Reconstruction for Free-Breathing Liver DCE-MRI (2023)

Dynamic contrast-enhanced MRI (DCE-MRI) of the liver offers structural and functional information for assessing the contrast uptake visually. However, respiratory motion and the requirement of high temporal resolution make it difficult to generate high-quality DCE-MRI. In this study, we proposed a novel deep learning based motion transformation integrated forward-Fourier (DL-MOTIF) reconstruction using motion fields derived from a deep learning Phase2Phase (P2P) network and deep learning priors from a residual network on severely undersampled DCE. This approach reconstructs sharp motion-free DCE images with artifacts removal by incorporating deep learning motion fields for motion integration and deep learning priors for regularization.
Reaction of Phenyl Isocyanate and Phenyl Isothiocyanate with the Ge(100)-2 × 1 Surface (2010)

The adsorption of phenyl isocyanate and phenyl isothiocyanate at the Ge(100)-2 × 1 surface was probed using multiple internal reflection Fourier transform infrared (FTIR) spectroscopy, density functional theory (DFT), and X-ray photoelectron spectroscopy (XPS). Results for phenyl isocyanate indicate that the saturation product is a [2 + 2] cycloaddition reaction product across the C═N bond, forming a surface-bound carbonyl. DFT reveals that this is the most stable of the expected products, and its calculated vibrational spectrum agrees closely with experimental spectra. FTIR spectroscopy studies of phenyl isothiocyanate reveal multiple surface adducts, with the product of the [2 + 2] cycloaddition reaction across the C═S bond as the major species and the product of the [2 + 2] cycloaddition reaction across the C═N bond as a minor product. In addition to these products, an excess of sulfur measured by XPS indicates the presence of a dissociative desorption product. The DFT calculated pathways and vibrational spectra for phenyl isothiocyanate confirm the FTIR and XPS assignments, and suggest the 1,3-dipolar cycloaddition product as a potential pathway for dissociative desorption.
Abstract 4104: Development of adoptive T-cell therapies to target heterogeneity of mCRPC (2023)

Abstract Metastatic castration resistant prostate cancer (mCRPC) remains a significant challenge with limited durable therapeutic responses, and innovative and effective treatment strategies are needed. Advanced mCRPC often comprises a heterogeneous population of prostate adenocarcinoma (PrAd) and neuroendocrine prostate cancer (NEPC), and current targeted therapies often result in transient anti-tumor responses. Chimeric antigen receptor (CAR) T-cell therapies are being actively investigated to target mCRPC, including CARs targeting antigens that are overexpressed in PrAd. Our group has developed a CAR T cell targeting the PrAd antigen, prostate stem cell antigen (PSCA), and have an ongoing phase 1 trial at City of Hope in patients with mCRPC. However, we anticipate that targeting NEPC in addition to PrAd will be required to achieve durable anti-tumor responses in patients. Here, we have developed novel dual-targeting approaches for the simultaneous treatment of both PrAd and NEPC. Our first approach optimizes a tandem CAR T-cell approach capable of targeting distinct antigens found on both PrAd and NEPC. Additionally, we are actively developing combinations of PSCA-CAR T-cells with secretable T-cell bispecific antibodies to target NEPC antigens. Our studies encompass the in vitro and in vivo safety and efficacy of CAR T-cells engineered to co-target PrAd and NEPC for the treatment of heterogeneous mCRPC. Citation Format: Lupita S. Lopez, Nathanael Bangayan, Owen Witte, Saul J. Priceman. Development of adoptive T-cell therapies to target heterogeneity of mCRPC. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4104.
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins (2007)

Next-generation photodynamic therapy agents will minimize extraneous phototoxicity by being active only at the target site. To this end, we have developed a model system to systematically investigate the excited-state quenching ability of a number of metalloporphyrins. Central metal ions that prefer four-coordinate, square planar orientations (Ag(II), Cu(II), Ni(II), Pd(II), and Zn(II)) were used. Porphyrin dimers based on 5-(4-aminophenyl)-10,15,20-triphenylporphyrin and comprising both a free base porphyrin and a metalloporphyrin covalently linked through a five-carbon alkyl chain were synthesized. The fluorescence and singlet oxygen quantum yields for the dimers were probed at 630 and 650 nm, respectively, resulting in the excitation of only the free base porphyrin and allowing a comparison of the quenching efficacy of each central metal ion. These results demonstrate that metalloporphyrins can serve as efficient quenchers, and may be useful in the design of novel light-activated therapeutic agents.
Liquid ventilation during early development: theory, physiologic processes and application. (1990)

Clinical statistics indicate that extrauterine viability becomes increasingly compromised at earlier gestational ages. It is generally accepted that this trend is largely due to the immaturity of the pulmonary system. Investigators have attributed the high degree of instability during the perinatal period of the preterm infant to incomplete biochemical development of the lung. Whereas disruption in biochemical development results in alveolar surfactant deficiency, elevated interfacial tension, alveolar instability, and inadequate pulmonary gas exchange, it is possible that incomplete development of other components within the pulmonary as well as other organ systems may also influence ultimate extrauterine viability of the preterm neonate. However, until recently, little was known in this regard as conventional gas ventilation techniques have been unsuccessful in supporting a stable animal preparation for controlled experimental investigation of physiologic processes before approximately 85% gestation. In the early 1970s, the concept of liquid ventilation was applied to the preterm and newborn animal. Since this time, technological advances in liquid delivery systems have established this experimental approach as a viable means to support the preterm infant during the transition from the liquid-filled intrauterine to gas-filled extrauterine environment. Reduction of surface tension, improvement in lung mechanics, effective pulmonary gas exchange, acid-base balance, improved distribution of pulmonary blood flow, and cardiovascular stability in the liquid ventilated preterm animal support the use of this alternative method of ventilation as a valuable experimental tool and potential clinical therapeutic modality during early development. The evolution of this approach is presented in this article.
Formation of Germa-ketenimine on the Ge(100) Surface by Adsorption of tert-Butyl Isocyanide (2017)

Reactions of the (100) surfaces of Ge and Si with organic molecules have been generally understood within the concept of "dimers" formed by the 2 × 1 surface reconstruction. In this work, the adsorption of tert-butyl isocyanide on the Ge(100)-2 × 1 surface at large exposures is investigated under ultrahigh vacuum conditions. A combination of infrared spectroscopy, X-ray photoelectron spectroscopy, and temperature-programmed desorption experiments along with dispersion-corrected density functional theory calculations is used to determine the surface products. Upon adsorption of a dense monolayer of tert-butyl isocyanide, a product whose structure resembles a germa-ketenimine (N=C=Ge) with σ donation toward and π back-donation from the Ge(100) surface appears. Formation of this structure involves divalent-type surface Ge atoms that arise from cleavage of the Ge(100)-2 × 1 surface dimers. Our results reveal an unprecedented class of reactions of organic molecules at the Ge(100) surface.
Lessons Learned from a Personal Sensing Architecture (2005)

For the past two years we’ve been using a personal sensing system we call SPEC. Because it has different goals it has a different design philosophy, and thus its architecture is quite different from the more common environmental sensing system. It was designed to monitor a user’s activities for their own purposes, in order to support everyday information processing activities. In other words, it is not a surveillance system. It uses collections of personal, private sensors, called SPECs, which can be worn, or deployed where each individual user needs them. This P2P system is designed on the principle that for widespread adoption the users must feel confident that whatever information they sense about themselves is kept under their own control, and not some central agency – however apparently benign. This places it in sharp distinction to RFID technology for example. After two years experience building applications with our system, we are convinced that this approach has a lot to offer, and we are embarking on a program to build an improved version, and take this opportunity to review the consequence of our design philosophy, and architecture, and identify areas for further research.
Effect of pressurization methods on the accuracy of wrist blood pressure measurement (2010)

In developing a wrist blood pressure monitor of high and reliable accuracy, the effect of different pressurization methods on the accuracy of blood pressure measurement at the wrist using oscillometry is investigated in this paper. 30 volunteers are recruited and blood pressure readings are taken with three different methods of pressurizing the wrist. It was found that measurement of mean arterial pressure (MAP) is more accurate when the wrist is locally compressed directly over the radial artery (-2.6 ± 11.4 mmHg) or with a region of surrounding tissue (10.3 ± 6.0 mmHg) than when the whole wrist is compressed by a conventional, constricting cuff (-11.4 ± 16.4 mmHg). Characteristics of accuracy, however, differ between the two local pressurization methods. While a square airbag that compresses the wrist directly over the radial artery may measure the most accurate MAP on average, the range of errors among individuals is large. Contrarily, measurements taken by pressurizing a region over the radial artery with a bladder are least affected by individual variability. In order to measure blood pressure accurately at the wrist while unbiased by the population-based algorithmic compensation to ensure accuracy among different individuals, therefore, the use of local pressurization method may be the most appropriate.
Job Recommendation from Semantic Similarity of LinkedIn Users’ Skills (2016)

Until recently job seeking has been a tricky, tedious and time consuming process, because people looking for a new position had to collect information from many different sources. Job recommendation systems have been proposed in order to automate and simplify this task, also increasing its effectiveness. However, current approaches rely on scarce manually collected data that often do not completely reveal people skills. Our work aims to find out relationships between jobs and people skills making use of data from LinkedIn users' public profiles. Semantic associations arise by applying Latent Semantic Analysis (LSA). We use the mined semantics to obtain a hierarchical clustering of job positions and to build a job recommendation system. The outcome proves the effectiveness of our method in recommending job positions. Anyway, we argue that our approach is definitely general, because the extracted semantics could be worthy not only for job recommendation systems but also for recruiting systems. Furthermore, we point out that both the hierarchical clustering and the recommendation system do not require parameters to be tuned.
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (2017)

Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents and the C8 position on the FQ core scaffold resulted in a remarkable enhancement of microbiological potency toward both Gram-positive and Gram-negative bacteria. Focused optimization of seven-membered ring composition, stereochemistry, and amine placement led to the discovery of the two lead compounds that were selected for further progression.
Predicting Progression of Autosomal Dominant Polycystic Kidney Disease by Changes in the Telomeric Epigenome (2022)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease with <i>Polycystin</i>&nbsp;(<i>PKD</i>) 1 and 2 gene mutation. However, the intra-familial variability in symptoms further suggests a non-Mendelian contribution to the disease. Our goal was to find a marker to track the epigenetic changes common to rapidly progressing forms of the disease. The risk of ADPKD increases with age, and aging shortens the telomere length (TL). Telomeres are a nucleoprotein structure composed mainly of three complexes, shelterin, CST and <i>RNA-containing telomere repeat</i><i>(TERRA)</i>, which protects the ends of chromosomes from degradation and fusion, and plays a role in maintaining cellular stability and in the repair of telomeric damage. <i>TERRAs</i> are transcribed from telomeric regions and a part of them is engaged in a DNA/RNA hybrid (R-loop) at each chromosome end. We tracked TL and <i>TERRA</i> levels in blood samples of 78 patients and 20 healthy control. Our study demonstrates that TL was shortened and <i>TERRA</i> expression levels in the DNA-attached fraction increased in autosomal dominant polycystic kidney patients with mutations in <i>PKD1</i> and <i>PKD2</i> compared to the control group. Moreover, it was observed that the expression of <i>TERRA</i> engaged in the R-loop was higher and the length of telomeres shorter in patients with ADPKD who showed rapid disease progression. Intrafamilial variation in TL and <i>TERRA</i> levels with the same mutation would indicate reliable epigenetic potential biomarkers in disease monitoring.
The use of cellulose (chromatography paper) as a cheap, versatile and non-covalent support for organic molecules during multi-step synthesis (2002)

Cellulose chromatography paper provides a novel non-covalent support for synthesis and in-situ purification of multi-dimensional arrays.
Novel Power Si/4H-SiC Heterojunction Tunneling Transistor (HETT) (2006)

We demonstrate a novel power Si/4H-SiC heterojunction tunneling transistor (HETT) on the basis of theoretical analysis and experimental results. The HETT is an insulated gate drive device and has a unique switching mechanism. In the off-state, the heterojunction barrier prevents current flow between the Si source region and the 4H-SiC drift region. In the on-state, the width of the heterojunction barrier is controlled by the gate bias to allow tunneling current to flow. The HETT has a zero channel length structure that is more independent of channel mobility compared with a conventional 4H-SiC MOSFET. As a result, the HETT is expected to have low on-resistance. A HETT was fabricated with n+-type polycrystalline silicon on an n--type 4H-SiC epitaxial wafer for power devices. The fabricated HETT shows a low specific on-resistance of 6.8 mcm2 (at Jd=500 A/cm2).
Wheat Gluten-Laminated Paperboard with Improved Moisture Barrier Properties: A New Concept Using a Plasticizer (Glycerol) Containing a Hydrophobic Component (Oleic Acid) (2012)

This paper presents a novel approach to reduce the water vapor transmission rate (WVTR) and water absorbance of wheat gluten/paperboard laminates by introducing a hydrophobic component (oleic acid (OA)) into the hydrophilic plasticizer (glycerol). Whereas the paperboard showed immeasurably high WVTR, the laminate with gluten/glycerol yielded finite values. More importantly, by incorporating 75 wt.% OA into the plasticizer, the WVTR and water absorbance were reduced by, respectively, a factor of three and 1.5–2. Of particular interest was that the mechanical properties were not changing dramatically between 0 and 50 wt.% OA. The results showed clear benefits of combining a gluten film with paperboard. Whereas the paperboard provided toughness, the WG layer contributed with improved moisture barrier properties. In addition, WVTR indicated that the paperboard reduced the swelling of the outer gluten/glycerol layer in moist conditions; a free standing gluten/glycerol film would yield infinite, rather than finite, WVTR values.
Surface Analysis of Reactive Ion Etched PZT Thin Films in SF6 Plasma (2007)

Reactive ion etching of sol-gel deposited Pb(Zr(0.52) Ti(0.48)03 thin films was performed in SF6 plasmas. Etch rate was determined as a function of cathode power and chamber pressure, attaining a value of 65 nm/min at 300 W. Auger electron spectroscopy measurements revealed an excess Pb 10 nm thin layer on as-deposited film surfaces. X -ray photoelectron spectroscopy measurements showed the existence of ZrF4 and PbS04 species on etched surfaces, in addition to traces of S and F. These measurements also indicated that Ti is relatively easy to remove while Pb removal is the rate limiting step in the etch process.
Axinellins A and B: New Proline-Containing Antiproliferative Cyclopeptides from the Vanuatu SpongeAxinella carteri (1998)

Two new bioactive cyclopeptides, named axinellins A (1) and B (2) have been isolated from the marine sponge Axinella carteri. Their structure elucidation was based on two-dimensional (2D) NMR (500 MHz) as well as HRFABMS and ESMS/MS data. All amino acid residues derived from axinellins A and B were found to possess L configuration at Cα by HPLC analysis of their FDAA derivatives (Marfey's method). The amino acid sequence of 1 and 2 was established on the basis of tandem mass spectrometry data (ESMS/MS) and on 1H-1H through-space connectivities observed in NOESY and ROESY spectra. Axinellins A (1) and B (2) exhibited moderate in vitro antitumor activity against human broncopulmonary non-small-cell-lung-carcinoma lines (NSCLC-N6) with IC50 values of 3.0 and 7.3 μg/ml, respectively.
Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion. (1994)

Previous studies have reported increased secretion of IL-1-like activity from mononuclear cells and increased circulating levels during the luteal phase of the menstrual cycle. In this investigation, specific RIAs for the agonists IL-1 alpha and IL-beta as well as IL-1 receptor antagonist (IL-1Ra) were used to determine whether differential IL-1 secretory patterns exist between men and women or between phases of the menstrual cycle. Mononuclear cells were isolated from six men and five women at 4-h intervals from 8 am to 8 pm, with the women studied once in midfollicular phase and once in midluteal phase. In the absence of any intentional stimulation, significant differences in secretion were observed between groups (p < 0.03) for all three species of IL-1: women's cells isolated during the luteal phase secreted 5- to 10-fold more than cells from men, and women's cells isolated during the follicular phase secreted 13- to 28-fold more than cells from men. In addition, total 24-h urine samples were collected in intervals with end points coinciding with the blood samples. Urinary excretion correlated with cellular secretion for IL-beta and IL-1Ra (p = 0.024 and 0.028, respectively), indicating that the in vitro results may correspond to differential processes occurring in vivo. Although greater absolute amounts of each species of IL-1 were secreted during the follicular phase, the ratio of agonist to antagonist secreted was greater in the luteal phase (p < 0.05), in agreement with previous studies of bioactivity. These results indicate that the regulation of IL-1 secretion is fundamentally different in women compared with men and alludes to the possibility that IL-1 may serve different biologic functions in women than men.
Error-Monitoring and Post-Error Compensations: Dissociation between Perceptual Failures and Motor Errors with and without Awareness (2013)

Whether humans adjust their behavior in response to unaware errors remains a controversial issue relevant to insight in neuropsychiatric conditions. Initial error awareness studies found that the error-related negativity (ERN), an event-related potential (ERP) originating in the medial prefrontal cortex after errors, activated equally for aware and unaware errors, suggesting a candidate preconscious mechanism. However, recent studies demonstrate that the ERN decreases after unaware errors. We hypothesized that the ERN is dependent upon awareness, and predicted that previous discrepancies might be due to unaware errors not being differentiated from perceptually uncertain, low-confidence responses that might increase the ERN amplitude. Here we addressed this hypothesis by distinguishing between aware errors, unaware errors, and uncertain responses, and using stimuli (faces) associated with well established sensory ERPs to evaluate the degree of stimulus processing for each trial type. We found that while aware and unaware errors were related to failures at the time of response, uncertain responses were due to failures at the time of stimulus processing indexed by lower amplitude sensory ERPs. Moreover, uncertain responses showed similar ERN activity as aware errors, in comparison with decreased activity for unaware errors. Finally, compared with aware errors, uncertain responses and unaware errors showed reduced neural compensations, such as alpha suppression. Together these findings suggest that the ERN is activated by aware motor errors as well as sensory failures, and that both awareness and certainty are necessary for neural adaptations after errors.
Mode-locked laser Raman spectroscopy. New technique for the rejection of interfering background luminescence signals (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMode-locked laser Raman spectroscopy. New technique for the rejection of interfering background luminescence signalsRichard P. Van Duyne, David L. Jeanmaire, and D. F. ShriverCite this: Anal. Chem. 1974, 46, 2, 213–222Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/ac60338a012https://doi.org/10.1021/ac60338a012research-articleACS PublicationsRequest reuse permissionsArticle Views413Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts