gebhart/patrepeval huggingface dataset:
Novel Potassium Channel Inhibitors (2020)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTNovel Potassium Channel InhibitorsBenjamin E. Blass*Benjamin E. BlassTemple University, School of Pharmacy, Moulder Center for Drug Discovery Research, Department of Pharmaceutical Sciences, Philadelphia, Pennsylvania 19140, United States*Email: [email protected]More by Benjamin E. Blasshttp://orcid.org/0000-0003-2449-4503Cite this: ACS Med. Chem. Lett. 2020, 11, 12, 2357–2358Publication Date (Web):November 23, 2020Publication History Received26 October 2020Published online23 November 2020Published inissue 10 December 2020https://pubs.acs.org/doi/10.1021/acsmedchemlett.0c00569https://doi.org/10.1021/acsmedchemlett.0c00569editorialACS PublicationsCopyright © Published by American Chemical Society 2020. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views999Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (861 KB) Get e-AlertscloseSUBJECTS:Alkyls,Calcium,Carbene compounds,Ions,Potassium Get e-Alerts
Early diagnostics of septicemia using microRNA flow cytometry (2016)

Abstract From 2000 to 2008 the incidence of sepsis in hospitals increased by 83%, but we still lack effective diagnostic methods. Recent advances in probe chemistry have enabled scientists to better detect RNA using flow cytometry. This technique could potentially be used for acute and efficient detection of sepsis. However, it still requires substantial validation before it reaches full potential in the clinic. We are in the process of creating a robust microRNA flow cytometry assay that can be used in the clinic for early detection of sepsis. In order to do this, first a reference control and diagnostic microRNA biomarkers, specific for detection of septicemia, must be identified and validated. Next, a microRNA flow cytometry assay will be developed and validated with the use of the reference control and diagnostic microRNAs both intracellularly and in serum. Lastly, the developed flow cytometry assay, including controls and diagnostic biomarkers will be verified against blood samples of clinical patients both positive and negative for sepsis. An effective sepsis diagnostic will save lives, aid in drug discovery, and decrease health care costs. This project provides a unique opportunity to create a robust flow cytometry assay to measure expression differences in microRNAs to detect septicemia in the clinic. We are hopeful that our continued efforts to validate and standardize previously published microRNA detection assays and expand the possible new targets will lead to quicker and more robust methods to survey for sepsis in clinics.
Evaluation of Femtosecond Time-bin Qubits Using Frequency Up-conversion Technique (2022)

Time-bin qubits, in which quantum information is encoded in a single photon at different times $Δ$t, are suitable for long-distance transmission via optical fibers. However, detection of time-bin qubits has been limited to the nanosecond range owing to the limited temporal resolution of single-photon detectors. In this study, we developed an up-conversion single-photon detector (UCSPD), using commercial nonlinear crystals of different lengths. By changing the crystal length and pump power, we quantitatively evaluated the efficiency and temporal resolution of the UCSPD and determined the optimal conditions for measuring femtosecond time-bin qubits. This detector achieved a temporal resolution of 415 fs and up-conversion efficiency of 10.1 %. Consequently, we successfully evaluated single-photon level pseudo femtosecond time-bin qubits with a pulse interval of only 800 fs.
TDEI issue CMD Editorial - Condition Monitoring and Diagnostics (2013)

This special issue of the IEEE Transactions on Dielectrics and Electrical Insulation (TDEI) is devoted to Condition Monitoring and Diagnostics (CMD) of high voltage insulation systems. Our intension was to pinpoint actual trends in this area of research and engineering. Especially the diagnostics of insulation systems of power equipment becomes particularly important, driven by multi-stress operational conditions and the strive for higher transmission capacity. Also the increasing requirements with respect to safety and reliability in electric power and industrial networks as well as their environmental compatibility set new and special demands.
Novel inhibitors of the osteoclast specific cysteine protease, cathepsin K (2006)

Daniel F. Veber, Dennis S. Yamashita, Hye-Ja Oh, Brian R. Smith, Kevin Salyers, Mark Levy, Chao-Pin Lee, Antonia Marzulli, Phil Smith, Ted Tomaszek, David Tew, Michael McQueney, George B. Stroup, Michael W. Lark, Ian E. James, and Maxine Gowen 6 Department of Medicinal Chemistry, Preclinical Pharmacokinetics, Bioformulations and Drug Delivery, Molecular Recognition, Protein Biochemistry, and Bone & Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, U.S.A.
T-Lymphocyte Changes Linked to Autoantibodies: Association of Insulin Autoantibodies With CD4+CD45R+ Lymphocyte Subpopulation in Prediabetic Subjects (1991)

The onset of insulin-dependent (type I) diabetes is predictable before hyperglycemia by the presence of islet cell autoantibodies (ICAs) and competitive insulin autoantibodies (CIAAs). CIAA+ICA+ first-degree relatives of individuals with type I diabetes have increased numbers of CD4 cells bearing the CD45R antigen and reciprocal depressions of the CD4 cells bearing the CD29 determinant. In addition, depressed CD4/CD8 ratios are present. In this study, we investigated the correlation between autoantibody levels and T-lymphocyte changes in the prediabetic state. The data demonstrate a clear linear relationship between rising CIAA levels, a marker of disease rate, and rising elevations in the CD4+CD45R+/CD4+CD29+ ratio in 37 CIAA+ICA+ and CIAA+ICA- relatives (r = 0.93). In marked contrast, the degree of CD4/CD8 depression found in individuals with prediabetes or long-term diabetes failed to correlate with either CIAA (r = 0.32) or ICA (r = 0.29) levels. The investigation of T-lymphocyte changes in siblings of individuals with type I diabetes with different stable autoantibody patterns (CIAAs and/or ICAs), and thus varying risks for diabetes, revealed differences in the prediabetic groups. Fifteen CIAA+ICA- relatives with high CIAA levels (greater than 80 nU/ml) had high CD4+CD45R+/CD4+CD29+ ratios (P = 0.03) and depressed CD4/CD8 ratios (P = 0.008). In contrast, CIAA+ICA- relatives with low CIAA levels (39-80 nU/ml), and thus low risk of diabetes, had no alteration in their CD4/CD8 ratio (P = 0.75) or CD4+CD45R+/CD4+CD29+ ratio (P = 0.33). Nineteen CIAA-ICA+ siblings with a predicted intermediate risk for diabetes showed heterogeneity in the presence of T-lymphocyte abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)
Supplementary Figure 2 from Functional Characterization of Filamin A Interacting Protein 1–Like, a Novel Candidate for Antivascular Cancer Therapy (2023)

Supplementary Figure 2 from Functional Characterization of Filamin A Interacting Protein 1–Like, a Novel Candidate for Antivascular Cancer Therapy
Supplementary Table 1 from <i>ATM</i> Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer (2023)

&lt;p&gt;siRNA and sgRNA sequences&lt;/p&gt;
A 40nm CMOS, 1.27nJ, 330mV, 600kHz, Bose Chaudhuri Hocquenghem 252 bits frame decoder (2010)

Following the will to answer to the energy constrained applications requirements, an Ultra-Low Voltage (ULV) 40nm Bose-Chaudhuri-Hocquenghem (BCH) error-correcting circuit is presented. Mapped on a ULV specific standard cells library, the circuit was designed following standard industrial implementation and verification flows. The BCH circuit runs at 0.330V, 600kHz frequency and needs 1.27nJ to decode a 252bits frame. With 14% of extra power compared to typical process, applying forward bias enables to compensate temperature and skewed process effects, regaining 150mV minimum operating voltage.
Supplementary Table 2 from <i>In Vitro</i> and <i>In Vivo</i> Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers (2023)

&lt;p&gt;SUPPLEMENTAL Table 2: Uterine serous cell lines with demographics, stage, histologic grade, primary site of tumor, Mean fluorescence intensity (MFI) and score for FRα (folic acid alpha receptor).&lt;/p&gt;
Reverse-type avalanche photodiode for scintillation detection and intrinsic energy resolution of BGO and GSO:Ce (2007)

In this paper we present a summary of a study of reverse-type avalanche photodiodes (APDs) used as scintillation detectors for X- and γ-ray spectroscopy. The energy resolution of the APDs was evaluated by varying the avalanche gain, M, in the range from 1 to 200. The best energy resolution recorded for the 662 keV <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs γ-ray photoabsorption peak was 8.3 ± 0.5 % using a 5 × 5 × 5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> BGO crystal coupled to a S8664-55 APD with a 5 × 5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> light sensitive window, manufactured by Hamamatsu Photonics, Inc. The measurement was made with a gain of 20 and at a temperature of −20 °C. The main advantage of this method is that an accurate value for the intrinsic resolution of the crystal can be easily obtained by subtracting the contribution to the energy resolution from circuit noise and the electron-hole pair statistics. The intrinsic energy resolution of the BGO crystal sample at 662 keV was found to be 6.5 ± 0.5%. The observed intrinsic energy resolution of BGO as a function of energy shows the same relationship as that shown in other published works. With this method the intrinsic energy resolution of GSO (Ce 0.5 % mol) was also measured. While the intrinsic energy resolution of BGO shows an energy dependence proportional to E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1/2</sup> , GSO has a step-like characteristic, with the energy resolution increasing from ∼100 keV up to ∼500 keV.
Active Learning for Linear Parameter-Varying System Identification (2020)

Active learning is proposed for selection of the next operating points in the design of experiments, for identifying linear parameter-varying systems. We extend existing approaches found in literature to multiple-input multiple-output systems with a multivariate scheduling parameter. Our approach is based on exploiting the probabilistic features of Gaussian process regression to quantify the overall model uncertainty across locally identified models. This results in a flexible framework which accommodates for various techniques to be applied for estimation of local linear models and their corresponding uncertainty. We perform active learning in application to the identification of a diesel engine air-path model, and demonstrate that measures of model uncertainty can be successfully reduced using the proposed framework.
Disturbance Effects in Extreme Ultraviolet Interferometric Lithography Affecting Interference Fringes (2010)

We set up an extreme ultraviolet (EUV) interferometer lithography tool dedicated to the study of the photoresist properties at the EUV wavelength. Two coherent beams are recombined to generate a standing wave, which can be recorded in a photoresist. However, other physical phenomena are generated by the interferometer structure which can disturb the quality of interference fringes. The Fresnel effect is one of these phenomena which is fully detailed in this work. Accurate numerical models have been compared to experimental studies to quantify the reduction of the interference area by the Fresnel effect. Depending on the Fresnel number ( N F ), several advantageous conditions are presented in order to reduce the Fresnel disturbance on resist.
Patient-reported activities after bilateral reverse total shoulder arthoplasties (2018)

Bilateral RSA can provide good functional outcome and high satisfaction. Patients manage most ADLs easily with some limitations in activities requiring extreme internal rotation.
Osmotically-induced Cleaning of Fouled Reverse Osmosis Membranes in Desalination (2019)

To counteract the effects of fouling, desalination plant operators ultimately resort to chemical cleaning, which incurs system downtime, risk of membrane damage, and the generation of chemical waste. Driven by these limitations, chemical-free cleaning has emerged as a potential alternative. Recent works have demonstrated the viability of osmotically-induced cleaning (OIC), where a membrane effectively undergoes osmotic backwashing. In light of conflicting reports, however, a deeper analysis and understanding of the underlying mechanisms involved is necessary. In this work, the effectiveness of OIC is examined, underlying mechanisms are elucidated, and potential applicability in the presence of spacers is investigated. Sodium alginate is adopted as a model organic foulant and commercial RO membranes are operated to emulate fouling conditions in practice. Video footage is presented to document the cleaning procedure and refine our understanding, while important observations are noted. Experimental results demonstrate effective cleaning, demonstrating a flux recovery of 10- 30% depending on experimental conditions, while membrane integrity is preserved. To investigate the effect of OIC on biofilms, a real biofilm of Cobetia marina is exposed to solutions of higher salinity. The results indicate that while exposure to higher salinities does impact the biofilm spread and bacterial count, the method is far from completely eliminating the biofilm or preventing its regrowth once operation is resumed. Keywords: Reverse osmosis; Membrane fouling; Chemical-free cleaning; Osmotically-induced foulant
Improving repair-based constraint satisfaction methods by value propagation (1994)

A constraint satisfaction problem (CSP) is a problem to find an assignment that satisfies given constraints. An interesting approach to CSP is a repair-based method that first generates an initial assignment, then repairs it by minimizing the number of conflicts. Min-conflicts hill climbing (MCHC) and GSAT are typical examples of this approach. A serious problem with this approach is that it is sometimes trapped by local minima. This makes it difficult to use repair-based methods for solving problems with many local minima.

We propose a new procedure, EFLOP, for escaping from local minima. EFLOP changes the values of mutually dependent variables by propagating changes through satisfied constraints. We can greatly improve the performance of repair-based methods by combining them with EFLOP.

We tested EFLOP with graph colorability problems, randomly generated binary CSPs and propositional satisfiability problems. EFLOP improved the performance of MCHC and GSAT for all experiments and was more efficient for large and difficult problems.
Langmuir‐Blodgett films of polymethacrylates with side chains containing functionalized aromatic schiff's bases (1993)

Abstract Langmuir‐Blodgett (LB) film formation has been investigated for polymers in which non‐linear optical (NLO) moieties are attached to the side chain of a polymethacrylate (PMA) backbone. Polymer monolayers were successfully transferred onto hydrophilic glass substrates using a moving‐wall type LB trough. The LB films were characterized by pressure‐area isotherms, polarized ultraviolet visible spectra, ellipsometry, and second harmonic generation measurements. The characterization shows that NLO moieties in the side chain are inclined at a shallow angle to the plane of the substrate. The second‐order nonlinear optical coefficient and molecular hyperpolarizability were also calculated. © 1993 John Wiley &amp; Sons, Inc.
ARTHROSCOPIC AUTOGRAFT OF THE ACL: PROSPECTIVE RANDOMISED STUDY OF PATELLAR TENDON VERSUS HAMSTRING GRAFTS IN 100 KNEES (2004)

Purpose: Free patellar tendon plasty is classically used for the treatment of chronic anterior instability of the knee. Good functional results may however be compromised by invalidating anterior pain. The purpose of this randomised trial was to obtain a prospective comparison of outcome after hamstring plasty or patellar tendon plasty. Material and methods: One hundred patients with an isolated tear of the anterior cruciate ligament were included in the study between May 1998 and 2001. Exclusion criteria were history of fracture, grade II laxity, and tear of the contralateral ACL. Patients were assigned to one of the treatment arms in random order in the operating room: Group A: arthroscopic free patellar tendon-bone graft; Group B: arthroscopic free four-strand hamstring graft. Two metal interference screws were used for fixation in all cases. The Aglietti method was used to calculate the position of the bore holes in all cases. The same rehabilitation protocol, in the same centre, was applied in all cases. The two groups were comparable for epidemiological, clinical, radiological, and instrumental laxity (KT1000®) data. IKDC criteria, activity level (sports), and instrumental measurement of laxity (KT1000® Medtronic) were used to assess outcome. Differences were considered significant for p Results: At mean follow-up (24 months, range 6 – 38) groups A and B were not significantly different for delay to resumed sports activity at the initial level, motion, clinical examination of ligaments, IKDC global score, and radiological evolution. At six months, 30% of the patients in group A complained of anterior pain; 20% of the patients still complained of pain at one year. In group B, femoropatellar pain or pain at the harvesting site was reported by 8% of the patients at six months and 4% at one year (p = 0.0005). These differences were no longer present at two years. The instrumental differential laxity was 0.66±1.1 mm in group A and 1±1.5 mm in group B (p =0.20). Two repeated trauma-induced tears were observed in group B. Conclusion: The preliminary results of this prospective randomised trial confirm the low morbidity of the harvesting site for hamstring grafts and the reliable stability of hamstring repair of isolated ACL laxity. A longer follow-up is however needed for long-term validation, particular concerning secondary distension of hamstring grafts as is frequently reported in the literature and which we have also observed in certain patients treated before this series.
55.4: A High‐Efficiency HTPS Projection Engine with LED Light Sources (2006)

Abstract A full high‐vision HTPS rear projection engine using light emitting‐diode (LED) light sources has been developed. Brightness comparable to that of current micro‐display projection televisions is obtained by using new collection optics and a polarization recycling system optimized for a LED light source.
Rectified catadioptric stereo sensors (2002)

It has been shown elsewhere how mirrors can be used to capture stereo images with a single camera, an approach termed catadioptric stereo. We present novel catadioptric sensors that use mirrors to produce rectified stereo images. The scanline correspondence of these images benefits real-time stereo by avoiding the computational cost and image degradation due to resampling when rectification is performed after image capture. First, we develop a theory which determines the number of mirrors that must be used and the constraints on those mirrors that must be satisfied to obtain rectified stereo images with a single camera. Then, we discuss in detail the use of both one and three mirrors. In addition, we show how the mirrors should be placed in order to minimize sensor size for a given baseline, an important design consideration. In order to understand the feasibility of building these sensors, we analyze rectification errors due to misplacement of the camera with respect to the mirrors.
BOA: Asbestos pipe insulation removal robot system. Phase 1 (1995)

The project described in this report targets the development of a mechanized system for safe, cost-efficient and automated abatement of asbestos containing materials used as pipe insulation. Based on several key design criteria and site visits, a proof-of-concept prototype robot system, dubbed BOA, was designed and built, which automatically strips the lagging and insulation from the pipes, and encapsulates them under complete vacuum operation. The system can operate on straight runs of piping in horizontal or vertical orientations. Currently we are limited to four-inch diameter piping without obstacles as well as a somewhat laborious emplacement and removal procedure -- restrictions to be alleviated through continued development. BOA removed asbestos at a rate of 4-5 ft./h compared to 3 ft./h for manual removal of asbestos with a 3-person crew. The containment and vacuum system on BOA was able to achieve the regulatory requirement for airborne fiber emissions of 0.01 fibers/ccm/ 8-hr. shift. This program consists of two phases. The first phase was completed and a demonstration was given to a review panel, consisting of DOE headquarters and site representatives as well as commercial abatement industry representatives. Based on the technical and programmatic recommendations drafted, presented and discussed during the review meeting, a new plan for the Phase II effort of this project was developed. Phase 11 will consist of a 26-month effort, with an up-front 4-month site-, market-, cost/benefit and regulatory study before the next BOA robot (14 months) is built, and then deployed and demonstrated (3 months) at a DOE site (such as Fernald or Oak Ridge) by the beginning of FY`97.