gebhart/patrepeval huggingface dataset:
Immunoglobulin Superantigen Protein L Induces IL-4 and IL-13 Secretion from Human FcεRI+ Cells Through Interaction with the κ Light Chains of IgE (2003)

Peptostreptococcus magnus protein L is a multidomain bacterial surface protein that correlates with virulence. It consists of up to five homologous Ig-binding domains (B1-B5) that interact with the variable domain of Ig kappa L chains. Intact protein L stimulates the synthesis and the release of IL-4 and IL-13 from human basophils in vitro. A protein L fragment covering the Ig-binding domains B1-B4 also induced IL-4 and IL-13 release from basophils. There was an excellent correlation (r(s) = 0.82; p < 0.001) between the maximal percent IL-4 release induced by protein L and that induced by anti-IgE and between intact protein L and the B1-B4 fragment (r(s) = 0.90; p < 0.01). Removal of IgE bound to basophils markedly reduced the IL-4 release induced by anti-IgE, protein L, and B1-B4. Preincubation of basophils with protein L or anti-IgE caused complete cross-desensitization to subsequent challenge with the heterologous stimulus. IgE purified from myeloma patients PS and PP (lambda chains) blocked anti-IgE-induced IL-4 release, but not the releasing activity of protein L. In contrast, IgE purified from myeloma patient ADZ (kappa chains) blocked both anti-IgE- and protein L-induced secretion. Cyclosporin A, but not cyclosporin H, inhibited protein L-induced release of IL-4 and IL-13 from basophils. Thus, protein L acts as a bacterial Ig superantigen to induce the synthesis and release of IL-4 and IL-13 from basophils by interacting with kappa L chains of the IgE isotype.
Taking the load off the conference chairs-towards a digital paper-routing assistant (1999)

This paper describes and extensively evaluates a system for the automatic routing of submitted papers to reviewers and area committees, without the need for any human annotation from the reviewers or the program chair. Routing is based on a profile of previous writings obtainable on-line for the reviewer pool, a generally stable and reusable resource that requires no manual adaptation for new submission streams. The paper explores a wide set of variations and extensions on the core model, and achieves system accuracy approaching that of several human judges on the same task.
Note sur le traitement informatique des palimpsestes (2002)

Letellier Laurent. Note sur le traitement informatique des palimpsestes. In: Le médiéviste et l'ordinateur, N°41, hiver 2002. L'apport cognitif. pp. 45-48.
Psychological Dysfunction Is Associated With Symptom Severity but Not Disease Etiology or Degree of Gastric Retention in Patients With Gastroparesis (2010)

Higher depression and anxiety scores are associated with gastroparesis severity on investigator- and patient-reported assessments. Psychological dysfunction does not vary by etiology or degree of gastric retention. Psychological features should be considered in managing gastroparesis.
Organocatalytic Asymmetric Synthesis of 1,2,3-prim,sec,sec-Triols (2006)

A tandem organocatalytic asymmetric synthesis of 1,2,3-triols using a,b-unsaturated aldehydes as the substrates and hydrogen peroxide as the oxidant is presented. The reaction can also be applied to the asymmetric synthesis of 3-chloro-1,2-propandiols.
Experimental evaluation of single‐domain antibodies predicted by molecular dynamics simulations to have elevated thermal stability (2019)

Recently Bekker et al. [Bekker G-J et al. Protein Sci. 2019;28:429-438.] described a computational strategy of applying molecular-dynamics simulations to estimate the relative stabilities of single-domain antibodies, and utilized their method to design changes with the aim of increasing the stability of a single-domain antibody with a known crystal structure. The structure from which they generated potentially stabilizing mutations is an anti-cholera toxin single domain antibody selected from a naïve library which has relatively low thermal stability, reflected by a melting point of 48°C. Their work was purely theoretical, so to examine their predictions, we prepared the parental and predicted stabilizing mutant single domain antibodies and examined their thermal stability, ability to refold and affinity. We found that the mutation that improved stability the most (~7°C) was one which changed an amino acid in CDR1 from an asparagine to an aspartic acid. This change unfortunately was also accompanied by a reduction in affinity. Thus, while their modeling did appear to successfully predict stabilizing mutations, introducing mutations in the binding regions is problematic. Of further interest, the mutations selected via their high temperature simulations, did improve refolding, suggesting that they were successful in stabilizing the structure at high temperatures and thereby decrease aggregation. Our result should permit them to reassess and refine their model and may one day lead to a usefulin silico approach to protein stabilization.
Breakage Resistance of Corn as a Function of Drying Rates (1985)

BREAKAGE resistance of two corn genotypes was investigated by means of breakage susceptibility tests and quasi-static compression tests. Corn samples dried at different air temperatures were used to investigate the effect of drying rates on the breakage strength of corn. As the drying rates increased, the breakage susceptibility increased; the average applied force and compressive energy absorbed at the bio-yield and rupture points for individual kernels decreased..
Partial-contact head-disk interface approach for high-density recording (2005)

A modern hard disk drive (HDD) generally requires a head-disk spacing of less than 10 nm. This paper focuses on studying slider vibration and designed several novel air bearing shapes to prevent slider vibration. An isolated pad slider and a narrow trailing edge slider were designed and fabricated for the feasibility study of the partial-contact interface. From the study, we found out that: 1) a slider with a smaller isolated pad had a smaller off-track vibration; 2) one with a smaller isolated pad had less aggressive disk lubricant depletion; and 3) a narrower trailing edge led to an easy transition from contact to flying.
Blocking Toll-Like Receptor Pathway Using an Antagonist of TLR7, 8 and 9 Reduces Inflammation in Dystrophin Deficient mdx Mice (PD3.004) (2013)

OBJECTIVE: The aim of this study was to evaluate the effect of an antagonist of Toll-like receptors (TLRs) 7, 8 and 9 in modulating disease phenotype in dystrophin deficient mdx mouse model of Duchenne muscular dystrophy (DMD).
High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer's Disease Via a Specific Tau Phosphorylation Pattern (2023)

These findings offer potential novel targets that can be used to develop tau-based therapies and biomarkers for use in AD.
Effects of mycelial culture of Phellinus linteus on ethanol‐induced gastric ulcer in rats (2006)

The gastroprotective effects of a mycelial culture of Phellinus linteus (MCPL) were evaluated by determining the ulcer index, gastric mucus content, histopathological observation and histochemical properties of mucin in an ethanol-induced ulcer model of rats. Preadministration with MCPL at doses of 20 and 60 mg/kg, showed a significant decrease of bleeding and ulcer index and alleviated the histopathological changes induced by ethanol such as hemorrhage and necrosis. Ethanol treatment decreased the gastric adhesion mucus content, but a higher level of gastric mucus persisted after preadministration of MCPL. As for the histochemical properties of mucins, marked changes were observed in both the surface and gland mucous cells in ethanol-treated rats, but these changes were detected only in the surface mucous cells in rat preadministered with MCPL. Using conventional methods for mucins, ethanol-treated rats revealed a decrease of neutral and acid mucin in the surface epithelium and mucous neck cells compared with normal rats. A marked decrease of BSL-1 by lectin histochemistry was also revealed in the ethanol-treated rats. But the MCPL preadministered rats showed similar stainabilities and lectin affinity patterns for mucins as the normal rats. These results indicate that pretreatment with MCPL provided protection of the gastric mucosa from ethanol-induced injury by maintaining the mucus barrier in rats.
Proenkephalin predicts organ failures, renal replacement therapy, and mortality in sepsis (2020)

Introduction Kidney failure frequently occurs in sepsis and is associated with high mortality. Proenkephalin (PENK) is an emerging biomarker for sepsis. We evaluated whether the PENK level could predict severity, organ failure, and 30‐day mortality in septic patients. Methods The PENK levels were measured using the sphingotest penKid assay (Sphingotec GmbH, Hennigsdorf, Germany) in a total of 215 septic patients. The PENK levels were analyzed in terms of sepsis severity, vasopressor use, 30‐day mortality, sequential (sepsis‐related) organ failure assessment (SOFA) renal subscore, the Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (CKD‐EPI eGFR) categories, and requiring renal replacement therapy (RRT). The number of organ failures, SOFA subscores, requiring RRT, and 30‐day mortality were compared according to the PENK quartiles. Results The PENK levels were significantly higher in patients with septic shock, vasopressor use, and non‐survivors than in patients with solitary sepsis, no vasopressor use, and survivors, respectively (all P &lt; 0.01). The PENK levels were significantly associated with SOFA renal subscore and CKD‐EPI eGFR categories (all P &lt; 0.0001). The PENK quartiles were associated with the number of organ failures as well as SOFA renal, cardiovascular, respiratory, and central nervous system subscores (all P &lt; 0.05). The PENK levels were significantly higher in patients who required RRT than in those who did not require RRT ( P &lt; 0.0001). High PENK level was also associated with high 30‐day mortality ( P &lt; 0.0001). Conclusions PENK could be a useful and objective marker to predict severity, organ failure, and 30‐day mortality in septic patients.
Robustness Properties in Fictitious-Play-Type Algorithms (2017)

Fictitious play (FP) is a canonical game-theoretic learning algorithm which has been deployed extensively in decentralized control scenarios. However standard treatments of FP, and of many other game-theoretic models, assume rather idealistic conditions which rarely hold in realistic control scenarios. This paper considers a broad class of best response learning algorithms that we refer to as FP-type algorithms. In such an algorithm, given some (possibly limited) information about the history of actions, each individual forecasts the future play and chooses a (myopic) best response strategy given their forecast. We provide a unified analysis of the behavior of FP-type algorithms under an important class of perturbations, thus demonstrating robustness to deviations from the idealistic operating conditions that have been previously assumed. This robustness result is then used to derive convergence results for two control-relevant relaxations of standard game-theoretic applications: distributed (network-based) implementation without full observability and asynchronous deployment (including in continuous time). In each case the results follow as a direct consequence of the main robustness result.
Robotic Cable Routing with Spatial Representation (2022)

Cable routing is a challenging task for robotic automation. To accomplish the task, it requires a high-level path planner to generate a sequence of cable configurations from the initial state to the target state and a low-level manipulation planner to plan the robot motion commands to transit between adjacent states. However, there are yet no proper representations to model the cable with the environment objects, impeding the design of both high-level path planning and low-level manipulation planning. In this letter, we propose a framework for cable routing with spatial representation. For high-level planning, by considering the spatial relations between the cable and the environment objects such as fixtures, the proposed method is able to plan a path from the initial state to the goal state in a graph. For low-level manipulation, multiple manipulation primitives are efficiently learned from human demonstration, to configure the cable to planned intermediate states leveraging the same spatial representation. We also implement a cable state estimator that robustly extracts the spatial representation from raw RGB-D images, thus completing the cable routing framework. We evaluate the proposed framework with various cables and fixture settings, and demonstrate that it outperforms some baselines in terms of reliability and generalizability.
The absolute configuration of (-)-ethyl .alpha.-formyl-.alpha.-methylphenylacetate and (-)-1,2-diphenyl-2-methyl-1,3-propanedione (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe absolute configuration of (-)-ethyl .alpha.-formyl-.alpha.-methylphenylacetate and (-)-1,2-diphenyl-2-methyl-1,3-propanedioneJohn M. Domagala and Robert D. BachCite this: J. Org. Chem. 1979, 44, 14, 2429–2433Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/jo01328a020https://doi.org/10.1021/jo01328a020research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Server-Side Local Gradient Averaging and Learning Rate Acceleration for Scalable Split Learning (2021)

In recent years, there have been great advances in the field of decentralized learning with private data. Federated learning (FL) and split learning (SL) are two spearheads possessing their pros and cons, and are suited for many user clients and large models, respectively. To enjoy both benefits, hybrid approaches such as SplitFed have emerged of late, yet their fundamentals have still been illusive. In this work, we first identify the fundamental bottlenecks of SL, and thereby propose a scalable SL framework, coined SGLR. The server under SGLR broadcasts a common gradient averaged at the split-layer, emulating FL without any additional communication across clients as opposed to SplitFed. Meanwhile, SGLR splits the learning rate into its server-side and client-side rates, and separately adjusts them to support many clients in parallel. Simulation results corroborate that SGLR achieves higher accuracy than other baseline SL methods including SplitFed, which is even on par with FL consuming higher energy and communication costs. As a secondary result, we observe greater reduction in leakage of sensitive information via mutual information using SLGR over the baselines.
Nanostructure control of age-hardenable Al 2024 alloy by high-pressure torsion (2014)

A concurrent strengthening process by high-pressure torsion (HPT) and fine precipitation hardening of an Al 2024 alloy has been studied. The HPT was conducted on disks of the alloys under an applied pressure of 6 GPa for 0.75 and 5 turns with a rotation speed of 1 rpm at room temperature. The HPT processing leads to microstructural refinement with an average grain size of ~240 nm and to an increase in hardness up to a saturation after 5 turns. Aging treatment is performed for sample after 5 turns at temperatures of 423 K for a maximum period up to 256 hours. The hardness increased above the hardness level after HPT processing through the subsequent aging. This study thus suggests that simultaneous hardening due to grain refinement and fine precipitation occurred by a combination of HPT processing and subsequent aging at 423 K.
Quantification of non–water‐suppressed MR spectra with correction for motion‐induced signal reduction (2009)

Intrascan subject movement in clinical MR spectroscopic examinations may result in inconsistent water suppression that distorts the metabolite signals, frame-to-frame variations in spectral phase and frequency, and consequent reductions in the signal-to-noise ratio due to destructive averaging. Frame-to-frame phase/frequency corrections, although reported to be successful in achieving constructive averaging, rely on consistent water suppression, which may be difficult in the presence of intrascan motion. In this study, motion correction using non-water-suppressed data acquisition is proposed to overcome the above difficulties. The time-domain matrix-pencil postprocessing method was used to extract water signals from the non-water-suppressed spectroscopic data, followed by phase and frequency corrections of the metabolite signals based on information obtained from the water signals. From in vivo experiments on seven healthy subjects at 3.0 T, quantification of metabolites using the unsuppressed water signal as a reference showed improved correlation with water-suppressed data acquired in the absence of motion (R(2) = 0.9669; slope = 0.94). The metabolite concentrations derived using the proposed approach were in good agreement with literature values. Computer simulations under various degrees of frequency and phase variations further demonstrated robust performance of the time-domain postprocessing approach.
Vertical GaN power FET on bulk GaN substrate (2016)

Lateral GaN transistors on Si substrates operating at voltage below 650 V are commercially available today. The main drawback of this lateral geometry is that the transistor area (and, therefore, its cost) is proportional to the breakdown voltage. In addition, numerous material interfaces are exposed to high electric fields, which reduces reliability and prevents avalanche breakdown. For higher-voltage high-current applications, the lateral-device size increases dramatically, and very high current levels are difficult to handle on just one surface. It is expected that vertical devices would reduce the die size and be more reliable as the electric field peaks far away from the surface. The most studied vertical GaN transistor, the current aperture vertical electron transistor (CAVET), has made significant progress in performance, but it still faces two challenges [1]. First, the CAVET structure requires a p-doped current blocking layer buried in the n-doped GaN layer. Fully activating the p-dopant Mg in GaN has been found very challenging and the vertical leakage current tends to be high. Second, the needs for a high quality regrowth of the AlGaN/GaN access region substantially increases the manufacturing cost. In this work, a novel vertical FET (VFET) structure on bulk GaN substrate has been developed to address the challenges of conventional power vertical GaN transistors (Fig. 1). This VFET structure does not require a p-doped GaN current-blocking layer or material regrowth. A GaN VFET with 0.5 V threshold voltage and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> on/off current ratio was demonstrated.
Atypical pharmacokinetics of atazanavir in an HIV‐1‐infected patient (2011)

An HIV-infected patient with very low atazanavir (ATV) plasma trough concentrations despite clinical signs of poor drug tolerability was described. By therapeutic drug monitoring (TDM), the authors found that the patient had an atypical ATV pharmacokinetics characterized by rapid drug absorption followed by very fast drug clearance probably attributable to his genetic background. This case underlines the importance of traditional and pharmacogenetic-based TDM for the individualization of ATV therapy in HIV-1 patients.
LLC-type series resonant convertor with PWM control (1994)

The steady-state analysis and performance characteristics of the LCC-type series resonant convertor (SRC) are presented. The analysis is based on the PWM control scheme for both continuous and discontinuous conduction mode of operations. By using the same control techniques, it is shown that the control characteristics of the LLC-type SRC are substantially improved over those of the conventional SRC. Convertor component stress curves are reported, and compared, under various load ranges, with the conventional SRC. Also computer simulation and experimental data are given to verify the theoretical results.
Crystal structure of chloromuconate cycloisomerase fromAlcaligenes eutrophusJMP134 (pJP4) at 3 Å resolution (1994)

Chloromuconate cycloisomerase (E.C. 5.5.1.7) is an enzyme involved in the 2,4-dichlorophenoxyacetate degradation pathway of Alcaligenes eutrophus JMP134 (pJP4). The crystal structure of this protein was determined at 3 A resolution by molecular-replacement techniques using atomic coordinates from the reported crystal structure of the homologous muconate cycloisomerase (E.C. 5.5.1.1) from Pseudomonas putida as the search model (42% identical positions in the sequences). Structure refinement by simulated-annealing and restrained least-squares techniques converged at R = 0.195. In the crystals studied, space group I4, the protein is present as two octamers per unit cell with two subunits per asymmetric unit. Each subunit consists of two globular domains, one of which forms an alpha/beta-barrel. Comparison of this structure with that of muconate cycloisomerase reveals the reasons for the altered substrate specificity of chloromuconate cycloisomerase. Marked differences are observed in polarity, accessibility and hydrogen-bonding potential in the channel leading into the active site as well as in the active center itself.