gebhart/patrepeval huggingface dataset:
Matrix-based orthogonal polynomials for MIMO transmitter linearization (2010)

Orthogonal polynomials have been considered as a powerful tool for power amplifier behavioral modeling and Digital Predistortion (DPD) linearization. The application of orthogonal polynomials was limited to SISO systems. This paper extends the idea to MIMO applications and demonstrates the linearization of 2×2 MIMO transmitters in the presence of RF crosstalk using matrix-based orthogonal polynomial linearization architecture. The performance of the proposed DPD has been evaluated using WCDMA and WiMAX standards. By incorporating the proposed DPD linearization topology, the measured ACPR of the WCDMA signal was improved from -42 dBc to -59 dBc and the measured EVM of WiMAX signal was reduced from -25 dB to -52 dB.
Acute peripartum twin–twin transfusion syndrome: Incidence, risk factors, placental characteristics and neonatal outcome (2013)

The incidence of acute peripartum TTTS is low (2.5%). Birth order and mode of delivery appear to be associated with increased risk of acute peripartum TTTS.
Evaluation of the antiparasitic activities of imidazol‐2‐ylidene–gold(I) complexes (2020)

A series of cationic gold(I)-carbene complexes with various 4,5-diarylimidazolylidene ligands were either newly prepared or repurposed for testing against protozoal Leishmania major, Toxoplasma gondii, and Trypanosoma brucei parasites. The syntheses of the new complexes 1b and 1c were described. Ferrocene compound 1a showed the highest activities against L. major amastigotes and T. gondii and distinct selectivity for T. gondii cells when compared with the activity against nonmalignant Vero cells. The ferrocene derivatives 1a-c are generally more active against the L. major amastigotes and the T. gondii tachyzoites than the other tested anisyl gold complexes and the approved drugs atovaquone and amphotericin B. Compounds 1a and 1e showed the highest selectivities for L. major amastigotes. Compounds 1d and 1f showed the highest selectivities for L. major promastigotes; 1f was the most active compound against L. major promastigotes of this series of compounds. The 3,4,5-trimethoxyphenyl analog 1b also exhibited a much greater selectivity for T. b. brucei cells when compared with its activity against human HeLa cells.
Oscillatory model of the hippocampal memory (2003)

We describe a biologically inspired oscillatory neural network for memorizing temporal sequences of neural activity patterns. The neural network consists of interactive neural oscillators with all-to-all excitatory connections forced by a slow T-periodic signal. The dynamics of the network are viewed through a time window with duration T. The network memorizes binary patterns in terms of low and high activity of the corresponding oscillators. The learning rule is temporally asymmetric, and it takes into account the activity level of pre- and post-"synaptic" oscillators in two contiguous time windows. Recall by the network is fast: all memorized patterns of sequences are reproduced in the correct order during the same time window, but with a short time delay. The applicability of these results to studies of the hippocampus is discussed.
Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity (2015)

We demonstrate that the t(1;11) translocation is associated with reduced white matter integrity in frontal commissural and association fibre tracts. These findings overlap with those shown in affected patients with psychosis and in DISC1 animal models and highlight the value of rare but biologically informative mutations in modeling psychosis.
Inlet/Engine Interactions in an Axisymmetric Pulse Detonation Engine System (2003)

The effects of oscillatory backpressure on the air induction system for pulse detonation engines were examined for an axisymmetric, external compression cone guration at a freestream Mach number of 2.1. The pressure perturbations at the diffuser exit were produced by a rotating mechanism simulating a valve, which periodically opened and closed the detonation tubes. Theoscillation frequency wasvaried from 30 to 100 Hzfor each individual tube. Through varying the downstream blockage, the spillage was altered, and different mass e ows wereobtained. In all casestheresults indicated that e uctuations in thestatic and stagnation pressures in the inletwere within 3%, without e ow instability noted near the inlet capture.
Sensitive detection of interleukin-6 on a plasmonic chip by grating-coupled surface-plasmon-field-enhanced fluorescence imaging (2014)

A plasmonic chip, which is a grating substrate coated with metal films, was fabricated and applied to grating-coupled surface-plasmon-field-enhanced fluorescence imaging (GC-SPFI). With the enhanced fluorescence excited by the surface plasmon field on the plasmonic chip, interleukin-6 (IL-6), a marker protein of lifestyle-related diseases, was measured using a sandwich assay system. IL-6 was quantitatively determined to be up to 2 pg/mL by GC-SPFI. The detection sensitivity for IL-6 was superior to that with an enzyme-linked immunosorbent assay, and GC-SPFI was shown to be a valid method for immunosensing.
Bone Marrow Stromal Cell-Mediated Gene Therapy for Hemophilia A: In Vitro Expression of Human Factor VIII with High Biological Activity Requires the Inclusion of the Proteolytic Site at Amino Acid 1648 (1999)

To evaluate the potential of the ex vivo bone marrow stromal cell (BMSC) system as a gene therapy for hemophilia A, we studied the in vitro expression of human factor VIII (hFVIII) in canine BMSCs following transfection with plasmid vectors and transduction with retroviral vectors. Vectors were composed of B domain-deleted forms of hFVIII that either retain or delete the proteolytic site at amino acid 1648. On transfection of BMSCs, vectors supported expression and secretion of similar levels of up to 386 mU/10(6) cells/24 hr, even though only 3-9% of the cells expressed hFVIII while 42-48% of transfected cells harbored plasmid vector. Much higher percentages (approximately 70%) of cells expressing hFVIII were achieved when BMSCs were transduced by retroviral vectors, resulting in expression and secretion as high as 1000-4000 mU/10(6) cells/24 hr. Western analysis demonstrated that the B domain-deleted forms possessing the proteolytic site were secreted predominantly as heavy and light chain heterodimers that resemble native forms found in plasma. In contrast, the hFVIII lacking the proteolytic site was expressed mostly as unprocessed, single heavy-light chains. Both hFVIII forms were correctly cleaved and activated by thrombin. The proteolyzed hFVIII form possessed > or = 93% normal biological activity while the unproteolyzed form possessed consistently less than 55% normal biological activity and was therefore considered less suitable for therapeutic application. These results demonstrate that the BMSC system has potential utility in gene therapy for hemophilia A and stress the importance of selecting the appropriate hFVIII structure for prospective clinical use.
Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals (2022)

Abstract Increasing the confidence in using in vitro and in silico model-based data to aid the chemical risk assessment process is one, if not the most, important challenge currently facing regulatory authorities. A particularly crucial concern is to fully take advantage of scientifically valid Physiologically-Based Kinetic (PBK) models. Nevertheless, risk assessors remain still unwilling in employing PBK models within their daily work. Indeed, PBK models are not often included in current official guidance documents. In addition, most users have limited experience in using modelling in general. So, the complexity of PBK models, together with a lack to evaluation methods of their performances, certainly contributes to their under-use in practical risk assessment. This paper proposes an innovative and unified modelling framework, in both the writing of PBK equations as matrix ordinary differential equations (ODE), and in its exact solving simply expressed with matrix products. This generic PBK solution allows to consider as many as state-variables as needed to quantify chemical absorption, distribution, metabolism and excretion processes within living organisms when exposed to chemical substances. This generic PBK model makes possible any compartmentalisation to be considered, as well as all appropriate inter-connections between compartments and with the external medium. We first introduce our PBK modelling framework, with all intermediate steps from the matrix ODE to the exact solution. Then we apply this framework to bioaccumulation testing, before illustrating its concrete use through complementary case studies in terms of species, compounds and model complexity. Abstract Figure
Lyotropic Mesophase (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity (2022)

Identifying genetic variants associated with lower waist-to-hip ratio can reveal new therapeutic targets for abdominal obesity. We use exome sequences from 362,679 individuals to identify genes associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI), a surrogate for abdominal fat that is causally linked to type 2 diabetes and coronary heart disease. Predicted loss of function (pLOF) variants in INHBE associate with lower WHRadjBMI and this association replicates in data from AMP-T2D-GENES. INHBE encodes a secreted protein, the hepatokine activin E. In vitro characterization of the most common INHBE pLOF variant in our study, indicates an in-frame deletion resulting in a 90% reduction in secreted protein levels. We detect associations with lower WHRadjBMI for variants in ACVR1C, encoding an activin receptor, further highlighting the involvement of activins in regulating fat distribution. These findings highlight activin E as a potential therapeutic target for abdominal obesity, a phenotype linked to cardiometabolic disease.
High-quality InN grown by RF-plasma assisted molecular beam epitaxy as novel materials for optical communication (2004)

High quality InN films were grown by rf-plasma assisted molecular beam epitaxy. The fundamental bandgap was evaluated to be 0.7 eV. The room temperature photoluminescence (PL) intensity was improved with the narrow PL-FWHM of 88 meV by optimizing the V/III supply ratio and buffer layer. This result suggests that InN is a new attractive material for optical devices in the optical communication wavelength.
An Integrated Surface Micromachined Capacitive Lateral Accelerometer with 2µG/√Hz Resolution (2002)

A capacitive position measurement interface minimizes noise from parasitics in the electromechanical interface and uses correlated double sampling to achieve better than 10 -3 /Hz displacement resolution.
Bio‐Organic Chiral Nematic Materials with Adaptive Light Emission and On‐Demand Handedness (2021)

Real-time active control of the handedness of circularly polarized light emission requires sophisticated manufacturing and structural reconfigurations of inorganic optical components that can rarely be achieved in traditional passive optical structures. Here, robust and flexible emissive optically-doped biophotonic materials that facilitate the dynamic optical activity are reported. These optically active bio-enabled materials with a chiral nematic-like organization of cellulose nanocrystals with intercalated organic dye generated strong circularly polarized photoluminescence with a high asymmetric factor. Reversible phase-shifting of the photochromic molecules intercalated into chiral nematic organization enables alternating circularly polarized light emission with on-demand handedness. Real-time alternating handedness can be triggered by either remote light illumination or changes in the acidic environment. This unique dynamic chiro-optical behavior presents an efficient way to design emissive bio-derived materials for dynamic programmable active photonic materials for optical communication, optical coding, visual protection, and visual adaptation.
Epitaxial MgO on GaAs(111) as a buffer layer for z-cut epitaxial lithium niobate (1993)

The epitaxial system z-lithium niobate on GaAs(111)A and GaAs(111)B has been demonstrated by in situ pulsed laser deposition both with and without intermediate layers of MgO(111). The in-plane epitaxial relationships are LiNbO3[110]∥GaAs[2̄11] and [21̄1̄] indicating the existence of 180° boundaries in the LiNbO3 both with and without the MgO layer, which grows cube-on-cube with the GaAs. Out-of-plane texture is typically 1.0° and 1.2° for the MgO and LiNbO3 layers, respectively. In-plane texture is typically 2.8° and 4.5° for the MgO and LiNbO3 layers, respectively. This epitaxial system may be useful for monolithic electro-optic or frequency doubling applications in conjunction with semiconductor laser diodes.
Pteridines, Sterols, and Indole Derivatives from the Lithistid Sponge Corallistes undulatus of the Coral Sea (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPteridines, Sterols, and Indole Derivatives from the Lithistid Sponge Corallistes undulatus of the Coral SeaAntonio Guerriero, Michele D'Ambrosio, Francesco Pietra, Cécile Debitus, and Olivier RibesCite this: J. Nat. Prod. 1993, 56, 11, 1962–1970Publication Date (Print):November 1, 1993Publication History Published online1 July 2004Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/np50101a015https://doi.org/10.1021/np50101a015research-articleACS PublicationsRequest reuse permissionsArticle Views336Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Radiotherapy for locally advanced esophageal cancer]. (1998)

The conventional treatment for patients with locally advanced esophageal cancer has been surgery or radiotherapy. The indication of the treatment depends on the location of the primary tumor, tumor stage, resectability of the lesion and operability of the patient. Radiotherapy is used in a case refusing surgery, medical contraindications to surgery, extensive locoregional disease or poor general condition. The survival rate by surgery alone or radiotherapy alone is poor. Thus, single modality therapy is not a standard treatment, but combined multimodal therapy including chemotherapy is a standard approach for locally advanced esophageal cancer. Further studies of optimization of multimodal therapies which are surgery and/or radiotherapy combined with chemotherapy are needed to improve the results in the treatment of esophageal cancer.
Geometrical control of the resonances and mode composition in hybrid plasmonic photonic crystals (2013)

Hybrid optical materials combining metallic plasmonic and dielectric photonic crystals in one hetero-structure possess several resonance mechanisms which critically influence light transport. In particular, a hybrid consisting of a monolayer of dielectric spheres assembled on a metal film-coated substrate simultaneously supports dielectric and surface plasmon polaritons (SPPs), Fabry-Perot resonances of the effective dielectric slab and Mie resonances of individual spheres. A seemingly powerful method to control the optical behavior of such hybrids is to play with the package density of spheres in the monolayer. But up to now this approach achieved only incremental variations. However, in this report we demonstrate that reduction of the sphere size by preserving the lattice constant brings dramatic changes to the optical response of the structure, if a semitransparent metal substrate is used.
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells (2016)

NAD<sup>+</sup> is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD<sup>+</sup> precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we show that nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN for NAD<sup>+</sup> synthesis. Using genetic gain- and loss-of-function models, we further demonstrate that the role of NRK1 in driving NAD<sup>+</sup> synthesis from other NAD<sup>+</sup> precursors, such as nicotinamide or nicotinic acid, is dispensable. Using stable isotope-labelled compounds, we confirm NMN is metabolized extracellularly to NR that is then taken up by the cell and converted into NAD<sup>+</sup>. Our results indicate that mammalian cells require conversion of extracellular NMN to NR for cellular uptake and NAD<sup>+</sup> synthesis, explaining the overlapping metabolic effects observed with the two compounds.
Regioselective Generation of Single‐Site Iridium Atoms and Their Evolution into Stabilized Subnanometric Iridium Clusters in MWW Zeolite (2020)

Abstract Preparation of supported metal catalysts with uniform particle size and coordination environment is a challenging and important topic in materials chemistry and catalysis. In this work, we report the regioselective generation of single‐site Ir atoms and their evolution into stabilized subnanometric Ir clusters in MWW zeolite, which are located at the 10MR window connecting the two neighboring 12MR supercages. The size of the subnanometric Ir clusters can be controlled by the post‐synthesis treatments and maintain below 1 nm even after being reduced at 650 °C, which cannot be readily achieved with samples prepared by conventional impregnation methods. The high structure sensitivity, size‐dependence, of catalytic performance in the alkane hydrogenolysis reaction of Ir clusters in the subnanometric regime is evidenced.
Electronic Image Stabilization System for Video Cameras and VCRs (1992)

Further miniaturization (size and weight reductions) and zooming capability enhancement have made consumer-grade video cameras as popular as VCRs with general consumers. As the result of these trends, however, some problems have surfaced, such as poor playback image quality due to fluctuation of images captured by the handheld video cameras. In recognition of these problems, Matsushita has developed an image stabilization system that is based entirely on image-processing techniques and that is small enough to be incorporated into compact video cameras and VCRs.
Premenstrual Dysphoria: An Illustrative Example of How Serotonin Modulates Sex-Steroid—Related Behavior (2001)

Abstract Premenstrual dysphoria (PMD) is a severe form of premenstrual syndrome, causing a marked reduction in the quality of life for about 5% of all women of fertile age. The cardinal symptoms are irritability and anger, which surface regularly between ovulation and menstruation and disappear completely within a few days after the onset of menstruation. Other frequent symptoms are depressed mood, affect lability, tension, and carbohydrate craving. In placebo-controlled trials, the serotonin reuptake inhibitors (SRIs) clomipramine, fluoxetine, sertraline, paroxetine, and citalopram have proven very effective for PMD, with a response rate of 60% or higher; in contrast, nonserotonergic antidepressants are not effective. The onset of action of SRIs is rapid, allowing for intermittent administration during luteal phases only. The impressive effect of SRIs for PMD is probably not equivalent to the antidepressant effect of these drugs, but is more likely to be a manifestation of the well-established influence of serotonin on aggression and irritability. It strongly reinforces the assumption that a major function of serotonergic neurons in the brain is to modulate sex-steroid—driven behavior.
Poster 242 Immediate Massage Stimulates Muscle Regeneration, Angiogenesis, and Decreases Fibrosis after Muscle Injury (2014)

PM&RVolume 6, Issue 9S p. S178-S179 Best Musculoskeletal Medicine Research Poster Presentation Poster 242 Immediate Massage Stimulates Muscle Regeneration, Angiogenesis, and Decreases Fibrosis after Muscle Injury Kunj G. Patel MD, Kunj G. Patel MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorMakoto Kobayashi MD, Makoto Kobayashi MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorScott Crawford BS, Scott Crawford BS Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorBurhan Garaibeh PhD, Burhan Garaibeh PhD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorAshlee Phelps AB, Ashlee Phelps AB Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorTom Best MD, Tom Best MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorJohnny Huard PhD, Johnny Huard PhD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this author Kunj G. Patel MD, Kunj G. Patel MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorMakoto Kobayashi MD, Makoto Kobayashi MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorScott Crawford BS, Scott Crawford BS Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorBurhan Garaibeh PhD, Burhan Garaibeh PhD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorAshlee Phelps AB, Ashlee Phelps AB Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorTom Best MD, Tom Best MD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this authorJohnny Huard PhD, Johnny Huard PhD Univ of Pittsburgh, Pittsburgh, PA, United StatesSearch for more papers by this author First published: 29 September 2014 https://doi.org/10.1016/j.pmrj.2014.08.395Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat No abstract is available for this article. Volume6, Issue9SSeptember 2014Pages S178-S179 RelatedInformation