gebhart/patrepeval huggingface dataset:
Design of a Haptic Stick Interface as a Pilot's Assistant in a High Turbulence Task Environment (1997)

A study involving 8 Air Force pilots was conducted to examine the efficacy of a force-reflecting joystick to improve performance during a simulated landing task in wind turbulence. By adding certain force characteristics to a joystick, it was of interest to see if performance may change, different control effort may be utilized, and workload measures may be altered based on the joystick utilized. The main results show that certain performance measures significantly improved by having the force reflection condition on. The implications of this study are that in certain types of precision tracking tasks, subjected to external disturbances, the addition of the force characteristics to the joystick can significantly improve performance, result in less effort for control, and lower subjective workload.
Heterotopic Ossification Has Some Nerve (2010)

Heterotopic ossification, defined as the formation of bone in abnormal anatomic locations, can be clinically insignificant or devastating and debilitating, depending on the site and duration of new bone formation. There are many causes of heterotopic ossification (HO), including soft tissue trauma, central nervous system injury, vasculopathies, arthropathies, and inheritance. One of the least understood components of HO is the interaction of the peripheral nervous system with the induction of this process. Recent work has shown that, upon traumatic injury, a cascade of events termed neurogenic inflammation is initiated, which involves the release of neuropeptides, such as substance P and calcitonin gene related peptide. Release of these peptides ultimately leads to the recruitment of activated platelets, mast cells, and neutrophils to the injury site. These cells appear to be involved with both remodeling of the nerve, as well as potentially recruiting additional cells from the bone marrow to the injury site. Further, sensory neurons stimulated at the injury site relay local information to the brain, which can then redirect neuroendocrine signaling in the hypothalamus towards repair of the injured site. While numerous studies have highlighted the important role of nerve-derived signals, both central and peripheral, in the regulation of normal bone remodeling of the skeleton,1 this review focuses on the role of the local, peripheral nerves in the formation of heterotopic bone. We concentrate on the manner in which local changes in bone morphogenetic protein (BMP) expression contribute to a cascade of events within the peripheral nerves, both sensory and sympathetic, in the immediate area of HO formation.
Lavandulyl Flavonoids from Sophora flavescens Suppress Lipopolysaccharide-Induced Activation of Nuclear Factor-.KAPPA.B and Mitogen-Activated Protein Kinases in RAW264.7 Cells (2010)

Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK), key regulators of cellular inflammatory and immune responses. Previously, we examined LDL-antioxidant activities of the nine flavonoids isolated from Sophora flavescens. Among these, two lavandulyl flavonoids, kurarinone (1) and kuraridin (2) inhibited inducible nitric oxide synthase (iNOS)-dependent NO production and ROS generation, and suppressed remarkably the expression of inflammatory cytokines, CCL2, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Moreover, compounds 1 and 2 attenuated NF-kappaB activation by inhibition of IkappaBalpha proteolysis and p65 nuclear translocation, as well as phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 MAP kinases.
X-ray Dark-Field Vector Radiography—A Novel Technique for Osteoporosis Imaging (2015)

X-ray dark-field vector radiography (XVR) has emerged as an imaging technique which can efficiently yield dark-field scatter images of high quality, even with conventional X-ray tube sources. The XVR yields direction-dependent information about the X-ray scattering of the trabecular bone microstructure without the requirement of resolving the micrometer size structures directly causing the scattering. In this pilot study, we demonstrated that XVR-based degree of anisotropy correlated with femoral bone strength in the context of osteoporosis.
Five-coordinate high-spin iron(II) complexes of synthetic macrocyclic ligands (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFive-coordinate high-spin iron(II) complexes of synthetic macrocyclic ligandsDaryle H. Busch, Philip H. Merrell, Virgil L. Goedken, and John Arthur StoneCite this: J. Am. Chem. Soc. 1970, 92, 26, 7590–7591Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/ja00729a017https://doi.org/10.1021/ja00729a017research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Wear-Corrosion of Reduced Graphene Oxide Functionalized with Hyaluronic Acid on Inflammatory and Proteomic Response of J774A.1 Macrophages (2023)

The presence of a worn surface in the implanted material, as in the case of a replacement of a damaged osteoarticular joint, is the normal condition after implantation. This manuscript focuses precisely on the comparative study of the cellular behavior on worn CoCr surfaces, analyzing the effect of different surface modifications on macrophages’ responses. CoCr surfaces were modified by the deposition of electrochemically reduced graphene oxide (CoCrErGO), followed by additional surface functionalization with hyaluronic acid (CoCrErGOHA). After the wear corrosion processes, the macrophage response was studied. In addition, macrophage supernatants exposed to the surfaces, before and after wear, were also evaluated for osteoblast response through the analysis of the metabolic activity, plasma membrane damage, and phosphatase alkaline activity (ALP). The proteomic analysis and the quantitative TNF-α/IL-10 ratios of the J774A.1 macrophages exposed to the surfaces under study showed a polarization shift from M0 (basal state) to M1, associated with the pro-inflammatory response of all surfaces. A lower M1 polarization was observed upon exposure to the surface modification with ErGO, whereas posterior HA functionalization attenuated, even more, the M1 polarization. The wear corrosion process contributed to inflammation and exacerbated the M1 polarization response on macrophages to CoCr, which was diminished for the ErGO and attenuated the most for the ErGOHA surfaces. Comparative proteomics showed that the pathways related to M1 polarization were downregulated on the surfaces of CoCrErGOHA, which suggests mechanisms for the observed attenuation of M1 polarization. The suitable immuno-modulatory potential induced by the ErGOHA surface, with and without wear, together with the stimulation of ALP activity in osteoblasts induced by macrophage supernatants, promotes the mineralization processes necessary for bone repair. This makes it feasible to consider the adsorption of ErGOHA on CoCr as a recommended surface treatment for the use of biomaterials in osseous joint applications.
Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases (2022)

We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence inhibitors. We identified from high-throughput screening assays a potential activity for avasimibe, a previously characterized acyl-coenzyme A: cholesterol acyltransferase inhibitor, in inhibiting the NleB and SseK arginine glycosyltransferases from Escherichia coli and Salmonella enterica, respectively. Avasimibe inhibited the activity of the Citrobacter rodentium NleB, E. coli NleB1, and S. enterica SseK1 enzymes, without affecting the activity of the human serine/threonine N-acetylglucosamine (O-GlcNAc) transferase. Avasimibe was not toxic to mammalian cells at up to 200 µM and was neither bacteriostatic nor bactericidal at concentrations of up to 125 µM. Doses of 10 µM avasimibe were sufficient to reduce S. enterica abundance in RAW264.7 macrophage-like cells, and intraperitoneal injection of avasimibe significantly reduced C. rodentium survival in mice, regardless of whether the avasimibe was administered pre- or post-infection. We propose that avasimibe or related derivates created using synthetic chemistry may have utility in preventing or treating bacterial infections by inhibiting arginine glycosyltransferases that are important to virulence.
Prevention of Senescence in Vasculature Through Quiescence (2018)

Prevention of cell senescence is a potential means to extend healthspan and perhaps lifespan. Agents that increase NAD+ levels, which are diminished with age, may be senopreventive through restoration of SIRT1 and normal mitochondrial activity. The ketone body [Formula: see text]-hydroxybutyrate ([Formula: see text]-HB) prevents senescence by inducing quiescence in endothelial cells. [Formula: see text]-HB activates hnRNP A1, which then binds and stabilizes Oct4 mRNA. In turn, expression of Oct4 in endothelial cells induces quiescence, which protects cells from DNA-damage-induced and replicative senescence, but not p53-mediated senescence. [Formula: see text]-HB, which increases in fasting, caloric restriction, and exercise, may synergize with agents that increase NAD+ levels in middle-aged and old animals and people to reduce the rate at which senescent cells form and alter metabolism. Moreover, observed induction of Oct4 by [Formula: see text]-HB in the brain as well suggests a possible nexus with reprogramming pathways in neural stem cells should be explored. The development of and potential combined efficacy of senolytic, senomodulatory, and senopreventive therapeutics may have significant benefits for maintaining healthspan and increasing lifespan.
Measurement of J/ψ production in pp collisions at $\sqrt{s}=2.76\;\mathrm{TeV}$ (2013)

A bstract The production of J/ψ mesons is studied with the LHCb detector using data from pp collisions at $\sqrt{s}=2.76$ TeV corresponding to an integrated luminosity of 71 nb −1 . The differential cross-section for inclusive J/ψ production is measured as a function of its transverse momentum p T . The cross-section in the fiducial region 0 &lt; p T &lt; 12 GeV /c and rapidity 2.0 &lt; $y$ &lt; 4.5 is measured to be 5.6 ± 0.1 (stat) ± 0.4 (syst) μ b, with the assumption of unpolarised J/ψ production. The fraction of J/ψ production from b -hadron decays is measured to be (7 . 1 ± 0 . 6 (stat) ± 0 . 7 (syst))%.
Loss Factor Estimation Using the Impulse Response Decay Method on a Stiffened Structure (2009)

High-frequency vibroacoustic modeling is typically performed using energy-based techniques such as Statistical Energy Analysis (SEA). Energy models require an estimate of the internal damping loss factor. Unfortunately, the loss factor is difficult to estimate analytically, and experimental methods such as the power injection method can require extensive measurements over the structure of interest. This paper discusses the implications of estimating damping loss factors using the impulse response decay method (IRDM) from a limited set of response measurements. An automated procedure for implementing IRDM is described and then evaluated using data from a finite element model of a stiffened, curved panel. Estimated loss factors are compared with loss factors computed using a power injection method and a manual curve fit. The paper discusses the sensitivity of the IRDM loss factor estimates to damping of connected subsystems and the number and location of points in the measurement ensemble.
Novel experimental and software methods for image reconstruction and localization in capsule endoscopy (2018)

The reconstruction methods, detailed above, were able to achieve good quality reconstruction of the bowel model and localization of the capsule trajectory using information from the CE video and images alone.
Observation of the Fixed Fe–CN–Mn Cluster in Cesium Manganese Hexacyanoferrate (2010)

The temperature-induced phase transition of cesium manganese hexacyanoferrate is based on the charge transfer between transition metal ions, and the behavior is complex. To clarify the mechanism for the phase transition, X-ray absorption and magnetic susceptibility were measured. The magnetic susceptibility behavior was different from that of rubidium manganese hexacyanoferrate. X-ray data analyses suggested that the phase transition of cesium manganese hexacyanoferrate is the result of a local charge transfer in the fixed Fe–CN–Mn cluster and the interaction among the clusters. Calculation of the Gibbs free energy of the mean-field model indicates that the cluster interaction influences the phase transition behavior of cesium manganese hexacyanoferrate.
Two-Photon Absorption in Core-Shell and Core-Only Semiconductor Quantum-Dots (2007)

We report experimental studies of two-photon absorption spectra of CdSe and CdSe/ZnS core/shell quantum-dots. The influence of the ZnS shell on the two-photon absorption is observed and discussed. © 2007 Optical Society of America.
Inappropriate Prehospital Ventilation in Severe Traumatic Brain Injury Increases In-Hospital Mortality (2010)

In the setting of acute brainstem herniation in traumatic brain injury (TBI), the use of hyperventilation to reduce intracranial pressure may be life-saving. However, undue use of hyperventilation is thought to increase the incidence of secondary brain injury through direct reduction of cerebral blood flow. This is a retrospective review determining the effect of prehospital hyperventilation on in-hospital mortality following severe TBI. All trauma patients admitted directly to a single level 1 trauma center from January 2000 to January 2007 with an initial Glasgow Coma Scale (GCS) score <or=8 were included in the study (n = 77). Patients without documented or with late (>20 min) arterial blood gas at presentation (n = 12) were excluded from the study. The remaining population (n = 65) was sorted into three groups based on the initial partial pressure of carbon dioxide: hypocarbic (Pco(2) < 35 mm Hg), normocarbic (Pco(2) 35-45 mm Hg), and hypercarbic (Pco(2) > 45 mm Hg). Outcome was based on mortality during hospital admission. Survival was found to be related to admission Pco(2) in head trauma patients requiring intubation (p = 0.045). Patients with normocarbia on presenting arterial blood gas testing had in-hospital mortality of 15%, significantly improved over patients presenting with hypocarbia (in-hospital mortality 77%) or hypercarbia (in-hospital mortality 61%). Although there are many reports of the negative impact of prophylactic hyperventilation following severe TBI, this modality is frequently utilized in the prehospital setting. Our results suggest that abnormal Pco(2) on presentation after severe head trauma is correlated with increased in-hospital mortality. We advocate normoventilation in the prehospital setting.
Data from Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Novel therapeutic targets are critical to unravel for the most common primary brain tumor in adults, glioblastoma (GBM). We have identified a novel synthetic lethal interaction between ClpP activation and HDAC1/2 inhibition that converges on GBM energy metabolism.&lt;/p&gt;Experimental Design:&lt;p&gt;Transcriptome, metabolite, and U-13C-glucose tracing analyses were utilized in patient-derived xenograft (PDX) models of GBM. Orthotopic GBM models were used for &lt;i&gt;in vivo&lt;/i&gt; studies.&lt;/p&gt;Results:&lt;p&gt;We showed that activation of the mitochondrial ClpP protease by mutant ClpP (Y118A) or through utilization of second-generation imipridone compounds (ONC206 and ONC212) in combination with genetic interference of HDAC1 and HDAC2 as well as with global (panobinostat) or selective (romidepsin) HDAC inhibitors caused synergistic reduction of viability in GBM model systems, which was mediated by interference with tricarboxylic acid cycle activity and GBM cell respiration. This effect was partially mediated by activation of apoptosis along with activation of caspases regulated chiefly by Bcl-xL and Mcl-1. Knockdown of the ClpP protease or ectopic expression of a ClpP D190A mutant substantially rescued from the inhibition of oxidative energy metabolism as well as from the reduction of cellular viability by ClpP activators and the combination treatment, respectively. Finally, utilizing GBM PDX models, we demonstrated that the combination treatment of HDAC inhibitors and imipridones prolonged host survival more potently than single treatments or vehicle &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;Conclusions:&lt;p&gt;Collectively, these observations suggest that the efficacy of HDAC inhibitors might be significantly enhanced through ClpP activators in model systems of human GBM.&lt;/p&gt;&lt;/div&gt;
An Algorithm for Grant-Free Random Access in Cell-Free Massive MIMO (2020)

Massive access is one of the main use cases of beyond 5G (B5G) wireless networks and massive MIMO is a key technology for supporting it. Prior works studied massive access in the co-located massive MIMO framework. In this paper, we investigate the activity detection in grant-free random access for massive machine type communications (mMTC) in cell-free massive MIMO network. Each active device transmits a pre-assigned non-orthogonal pilot sequence to the APs and the APs send the received signals to a central processing unit (CPU) for joint activity detection. We formulate the maximum likelihood device activity detection problem and provide an algorithm based on coordinate descent method having affordable complexity. We show that the cell-free massive MIMO network can support low-powered mMTC devices and provide a broad coverage.
P2‐065: Change in plasma beta‐amyloid level after glucose loading: A possible biomarker for Alzheimer's disease (2011)

With the emergence of a promising approach to treat Alzheimer's disease (AD) targeting the ß-amyloid (Aß) pathway, it is necessary to establish new diagnostic biomarkers that enable the antemortem diagnosis of AD. Although plasma Aß has been suggested as a non-invasive biomarker, its significance has been inconclusive. Thus, it is important to improve the diagnostic potential of plasma Aß. One of the potential approaches is to modify plasma Aß level using various modulators. In this study, we evaluated the influence of glucometabolic status on plasma Aß level in AD transgenic mouse and AD patients. We measured plasma Aß levels in fed and fasted states in two lines of APP-Tg mice (APP/PS1 and APP23 mouse), and also examined the change in plasma Aß levels during i.p. glucose tolerance test (2g/kg). Furthermore, we assessed the change in plasma Aß levels during oral glucose tolerance test in AD and non-AD patients. Interestingly, plasma Aß level in a fed state was significantly higher than that in a fasted state in both APP-Tg mice. Furthermore, plasma Aß level rapidly increased after glucose loading. More importantly, the magnitude of the increase in plasma Aß was significantly larger in APP-Tg mice than in wild-type littermates. Finally, we found the significantly different patterns of changes in Abeta levels during oral glucose tolerance test between AD and non-AD patients. Change in plasma Aß level after glucose loading is a possible biomarker for AD.
High temperature stability, interface bonding, and mechanical behavior in [beta]-NiAl and Ni[sub 3]Al matrix composites with reinforcements modified by ion beam enhanced deposition (1993)

Diffusion-bonded NiAl-Al[sub 2]O[sub 3] and Ni[sub 3]Al-Al[sub 2]O[sub 3] couples were thermally fatigued at 900 C for 1500 and 3500 cycles. The fiber-matrix interface weakened after 3500 cycles for the Saphikon fibers, while the Altex, PRD-166, and FP fibers showed little, if any, degradation. Diffusion bonding of fibers to Nb matrix is being studied. Coating the fibers slightly increases the tensile strength and has a rule-of-mixtures effect on elastic modulus. Push-out tests on Sumitomo and FP fibers in Ni aluminide matrices were repeated. Al[sub 2]O[sub 3] was evaporated directly from pure oxide rod onto acoustically levitated Si carbide particles, using a down-firing, rod-fed electron beam hearth; superior coatings were subsequently produced using concurrent irradiation with 200-eV argon ion-assist beam. The assist beam produced adherent films with reduced tensile stresses. In diffusion bonding in B-doped Ni[sub 3]Al matrices subjected to compressive bonding at 40 MPa at 1100 C for 1 hr, the diffusion barriers failed to prevent catastrophic particle- matrix reaction, probably because of inadequate film quality. AlN coatings are currently being experimented with, produced by both reactive evaporation and by N[sup +]-ion enhanced deposition. A 3-kW rod-fed electron-beam-heated evaporation source has been brought into operation.
Assessment of risk area during coronary occlusion and infarct size after reperfusion with myocardial contrast echocardiography using left and right atrial injections of contrast. (1993)

MCE performed with LA and RA injections of contrast in the presence of pharmacologically induced coronary hyperemia can be used to determine, in vivo, the risk area during coronary occlusion and infarct size after reperfusion. These results could have important implications in this era of myocardial reperfusion.