gebhart/patrepeval huggingface dataset:
ZF receive filtering for precoded MIMO systems (2013)

MIMO precoding matches the transmission to channel conditions in order to reduce or eliminate interference at the receiver. In this paper, we are interested in the case where the receiver is also equipped with a linear processor, specifically a ZF filter. We analyze the effect of the ZF receive filter on the performance of a variety of MIMO precoders. It is shown that receive-side ZF equalization can remove the error floors that sometimes appear with regularized zero-forcing precoding and matched-filter precoding.
CA: A Cancer Journal for Clinicians (2010)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Supplementary Methods, Table S2 from Co-occurring Genomic Alterations Define Major Subsets of <i>KRAS</i>-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities (2023)

&lt;p&gt;Supplementary Methods. Supplementary Table 2. Details of the antibody used for TTF1 immunostaining.&lt;/p&gt;
A 3D probabilistic atlas of normal human neuroanatomy (1997)

Phosphorylation of the regulatory (R) domain initiates cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel activity. To discover how the function of this domain is determined by its structure, we produced an R domain protein (R8) that spanned residues 708-831 of CFTR. Phosphorylated, but not unphosphorylated, R8 stimulated activity of CFTR channels lacking this domain, indicating that R8 is functional. Unexpectedly, this functional R8 was predominantly random coil, as revealed by CD and limited proteolysis. The CD spectra of both phosphorylated and nonphosphorylated R8 were similar in aqueous buffer. The folding agent trimethylamine N-oxide induced only a small increase in the helical content of nonphosphorylated R8 and even less change in the helical content of phosphorylated R8. These data, indicating that the R domain is predominantly random coil, may explain the seemingly complex way in which phosphorylation regulates CFTR channel activity.
Recent advances in temporally multiplexed and point aspect autostereoscopic displays (2006)

Implementation of an efficient 3D display with high-quality image is beneficiary for a variety of applications, including the entertainment industry, surveillance centers, advanced engineering design, etc. A number of 3D display systems are currently under the development, such as autostereoscopic 3D display (ASD), spatially multiplexed, volumetric and (electro) holographic. Temporally multiplexed ASD approaches have certain advantages as compared to other methods, especially in retaining the full resolution of the display and in providing large headboxes. The confluence of high framerate deformable mirror displays, graphical processing units (GPUs) capable of specialized rendering, high bandwidth commodity grade computer busses (particularly PCI-express) and rapidly switchable, high brightness LEDs have all served to make a high quality temporally multiplexed ASD viable. We report on the incorporation of the previously noted technologies within an ASD with multiple viewing zones and a look around capability. In addition, the same technologies allow for a practical realization of the aspect-in-point display (APD) concept, which couples the use of a temporally multiplexed display in conjunction with the faceted holographic optical elements to form a 3D image. In essence, the APD consists of a multiplex hologram that is electronically updated in a high-speed fashion, incorporating many of the advantages of the former.
Synthesis, characterization, glass transition behavior, and the electronic structure of high-molecular-weight, symmetrically substituted poly(ferrocenylsilanes) with alkyl or aryl side groups (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, glass transition behavior, and the electronic structure of high-molecular-weight, symmetrically substituted poly(ferrocenylsilanes) with alkyl or aryl side groupsDaniel A. Foucher, Ralf Ziembinski, Ben Zhong Tang, Peter M. Macdonald, Jason Massey, C. Raimund Jaeger, G. Julius Vancso, and Ian MannersCite this: Macromolecules 1993, 26, 11, 2878–2884Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ma00063a037https://doi.org/10.1021/ma00063a037research-articleACS PublicationsRequest reuse permissionsArticle Views645Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The hidden structure of human enamel (2019)

Enamel is the hardest and most resilient tissue in the human body. Enamel includes morphologically aligned, parallel, ∼50 nm wide, microns-long nanocrystals, bundled either into 5-μm-wide rods or their space-filling interrod. The orientation of enamel crystals, however, is poorly understood. Here we show that the crystalline c-axes are homogenously oriented in interrod crystals across most of the enamel layer thickness. Within each rod crystals are not co-oriented with one another or with the long axis of the rod, as previously assumed: the c-axes of adjacent nanocrystals are most frequently mis-oriented by 1°-30°, and this orientation within each rod gradually changes, with an overall angle spread that is never zero, but varies between 30°-90° within one rod. Molecular dynamics simulations demonstrate that the observed mis-orientations of adjacent crystals induce crack deflection. This toughening mechanism contributes to the unique resilience of enamel, which lasts a lifetime under extreme physical and chemical challenges.
Abstract 1634: A novel small molecule inhibitor of IRE1alpha reverses endocrine resistance in breast cancer cells (2014)

Abstract Over two-thirds of all breast cancer patients are estrogen receptor alpha positive (ER+). However, almost 50% of all ER+ breast tumors do not respond or respond and later fail on endocrine therapy. Resistance to endocrine therapy remains a significant clinical problem and advanced ER+ breast cancer is largely an incurable disease. The mechanisms of resistance to endocrine therapy remain unclear. We have reported that the unfolded protein response (UPR), a stress-induced cellular adaptive mechanism, acts as a switch controlling the balance between cell death and cell survival in response to these therapies. UPR is activated by three molecular sensors: IRE1alpha, ATF6, PERK. Several components of the UPR, including IRE1alpha, are up-regulated in endocrine resistant cells. We now report a novel small molecule inhibitor of IRE1alpha: N-(4-Phenoxy-phenyl)-2-(5-pyridin-3-yl-2H-[1,2,4]triazol-3-ylsulfanyl)-acetamide (NPPTA). We show that NPPTA interacts with IRE1alpha in vitro and can decrease IRE1alpha protein levels. NPPTA treatment alone inhibits cell proliferation in antiestrogen resistant ER+ breast cancer cells more effectively than in sensitive cells, and in a dose- and time-dependent manner. Normal breast epithelial cells are unaffected by NPPTA. In addition, NPPTA and TAM synergistically inhibit cell proliferation in TAM resistant breast cancer cells. NPPTA's activities are associated with induced G1 cell cycle arrest, increased apoptosis/necrosis, and inhibition of anti-apoptotic signaling. Targeting IRE1alpha may be a new and effective strategy to reverse endocrine resistance in breast cancer. Citation Format: Ayesha N. Shajahan-Haq, Jacqueline Smith, Siva Dakshanamurthy, Difei Wang, Ahreej E. Eltayeb, Milton L. Brown, Robert Clarke. A novel small molecule inhibitor of IRE1alpha reverses endocrine resistance in breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1634. doi:10.1158/1538-7445.AM2014-1634
Advancing Your Arduino Game (2022)

This fun, hands-on workshop will show how to include significant computing concepts in engaging, creative activities that are accessible to students who have completed CS1. Participants will use Arduinos (provided) and experience a studio-style learning environment which can serve as an example for studio-based learning in the classroom. The maker movement is taking off, with accessible microcontrollers, sensors, actuators, and 3-D printing capability enabling do-it-yourself hobbyists of all ages to tinker in ways that previously were unavailable to the general public. At the heart of many maker projects is computer control, yet computer science education (especially in the early years) is primarily centered around traditional computing platforms: desktops, laptops, and servers, not the microcontrollers that are prevalent in the maker community. This workshop introduces curricular materials that can turn amateur makers into professional designers, understanding the underlying principles that drive the artifacts that makers make. The theoretical concepts covered include principles that are often present when computers interact with the physical world, e.g., timing as a functional requirement, physical inputs and outputs, etc. Finite automata are also introduced, in the form of finite-state machines, as an example of a computational formalism that has immediate practical use. The materials for a semester-long course (textbook, lecture videos, studios, assignments) are all freely available. The course expands upon the workshop subjects to also include the concepts of information representation, computer communications, and basic computer organization/architecture.
Image sequences and wavelets for vibration analysis: Part 1: Edge detection and extraction of natural frequencies (2002)

The paper presents the application of the wavelet edge detection algorithm for structural vibration analysis based on image sequences. A number of different edge detection operators are briefly discussed and illustrated using a simple image example. The wavelet-based edge detection algorithm is then used to identify natural frequencies of a simple cantilever beam. The paper discusses a number of important issues that need to be confronted when using image sequences for vibration analysis. These include correspondence of image features from image to image and image calibration. The paper compares the natural frequencies obtained using such an approach and also another non-contact method and finds them in good agreement.
Sinus mucosal IL-8 gene expression in chronic rhinosinusitis (1999)

Sinus mucosal expression of the gene for IL-8 is increased in patients with chronic rhinosinusitis, and the level of IL-8 gene expression correlates with disease severity.
Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment (2020)

Biomarker PTEN/PAX2 signatures offer a valuable diagnostic aid to identify residual AH in progestin-treated endometrial samples for which the biomarker status from preprogestin treated AH is known. The findings of this study are promising for a possible future change of diagnostic practice.
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors (2023)

Abstract Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration. Here we show that the transcription factor Osr1 is essential for FAPs to communicate with MuSCs and infiltrating macrophages, thus coordinating muscle regeneration. Conditional inactivation of Osr1 impaired muscle regeneration with reduced myofiber growth and formation of excessive fibrotic tissue with reduced stiffness. Osr1-deficient FAPs acquired a fibrogenic identity with altered matrix secretion and cytokine expression resulting in impaired MuSC viability, expansion and differentiation. Immune cell profiling suggested a novel role for Osr1-FAPs in macrophage polarization. In vitro analysis suggested that increased TGFβ signaling and altered matrix deposition by Osr1-deficient FAPs actively suppressed regenerative myogenesis. In conclusion, we show that Osr1 is central to FAP function orchestrating key regenerative events such as inflammation, matrix secretion and myogenesis.
Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells (1993)

Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells is known to be down-regulated by the action of phorbol myristate acetate (PMA). We show here that in addition to suppressing the rate of transcription of the CFTR gene, PMA treatment stimulates degradation of the CFTR protein. HT-29 colon epithelial cells and the CFTR-transfected pancreatic cells PLJ-4.7 lost 55-80% of their CFTR protein after 3-6 h of treatment with 100 nM PMA, as analyzed by quantitative Western blotting. In contrast to PMA, actinomycin D and cycloheximide reduced the CFTR protein content by 19 and 9% in HT-29 cells and by 22 and 40% in PLJ-4.7 cells, respectively, while inhibiting total cellular RNA and protein synthesis by over 80%. The PMA-induced loss of CFTR was partially reversed by the protein kinase C inhibitor GF109203X. The PMA-induced degradation of CFTR may represent a regulatory pathway for terminating CFTR-mediated chloride and mucin secretion.
Interactive Error Control for Mobile Video Telephony (2007)

Error robust video communication for hand-held devices is a delicate task because of limited computational resources and hostile channel conditions in mobile environments. The loss of coded video data on the channel can result in spatio-temporal error propagation in the video. In addition, stringent end-to-end delays for conversational applications make this challenge even more difficult. In this work, we investigate several techniques which exploit feedback from the receiver to enhance the performance of conversational video in realistic mobile communication environments. Specifically, we show how a low-complexity interactive error tracking technique can be combined with multiple reference picture selection (RPS) based on the existing syntax of H.264/AVC. This technique outperforms other interactive error protection strategies by a margin of more than 2 dB for moderate channel loss rates, with minimal impact on end-to-end delays.
Design and operation of a human color vision inspired sensor for proximate standoff detection (2020)

The proliferation of chemical threats in the modern world requires the development of new, low cost, flexible sensors, with the ability to be widely deployed. Ideally these sensors will be capable of both proximate and standoff sensing of threats (i.e. not require intimate contact with the chemical) without the need for highly trained/specialized operators. To meet this unique set of requirements, we are developing a bio-inspired chemical sensing method modeled on human color vision. This bio-inspired approach provides the ability to quickly and reliably discriminate between chemicals based on the interaction of infrared chemical absorption bands with selected broadband infrared filters. Here we describe the capabilities of a prototype bio-inspired sensor for standoff detection of threat chemicals on surfaces versus common interferents. We discuss the design and operation of the bio-inspired sensor and preliminary data demonstrating its ability to discriminate between a nerve agent simulant dimethyl methylphosphonate (DMMP) and the common background interferent US Army insect repellant (containing N,N-Diethyl-meta-toluamide (DEET)) in a laboratory environment. We discuss paths forward for this technology, as well as how the bio-inspired sensing approach can result in high-confidence discrimination of threats at proximate standoff distances.
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis (2020)

Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance because such mechanisms can be leveraged as a therapy for obesity and related disorders. Here, we show that a designer protein-deprived diet enriched in free essential amino acids can <i>1</i>) promote the brown fat thermogenic program and fatty acid oxidation, <i>2</i>) stimulate uncoupling protein 1 (UCP1)-independent respiration in subcutaneous white fat, <i>3</i>) change the gut microbiota composition, and <i>4</i>) prevent and reverse obesity and dysregulated glucose homeostasis in multiple mouse models, prolonging the healthy life span. These effects are independent of unbalanced amino acid ratio, energy consumption, and intestinal calorie absorption. A brown fat-specific activation of the mechanistic target of rapamycin complex 1 seems involved in the diet-induced beneficial effects, as also strengthened by in vitro experiments. Hence, our results suggest that brown and white fat may be targets of specific amino acids to control UCP1-dependent and -independent thermogenesis, thereby contributing to the improvement of metabolic health.
Virtual cutter path display for dental milling machine (2009)

This paper presents the prototype of a mixed reality system using the computer controlled dental milling machine, which is called MRD Mill. First, overview of the core dental milling machine developed in this study is presented, showing its kinematics and mechanisms to achieve the objective of the dental treatment. Then the paper covers its basic functions, including joystick-based control, NC code-based control, manipulation recording, and replay operation for the manual manipulation. MRD Mill system was installed with a mixed reality technology using the dental milling machine as the core unit. MRD Mill system is designed to support the operation of the dental mill using the mixed reality technology. This paper shows superimpose of trajectory of cutting tool path and virtual objects over the physical model. Then discussion and future direction will be followed.
Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus (2017)

Favipiravir is a broad-spectrum antiviral agent that has demonstrated efficacy against Ebola virus (EBOV) in rodents. However, there are no published reports of favipiravir efficacy for filovirus infection of nonhuman primates (NHPs). Here we evaluated the pharmacokinetic profile of favipiravir in NHPs, as well as in vivo efficacy against two filoviruses, EBOV and Marburg virus (MARV). While no survival benefit was observed in two studies employing once- or twice-daily oral dosing of favipiravir during EBOV infection of NHPs, an antiviral effect was observed in terms of extended time-to-death and reduced levels of viral RNA. However, oral dosing in biosafety level-4 (BSL-4) presents logistical and technical challenges, and repeated anesthesia events may potentially worsen survival outcome in animals. For the third study of treatment of MARV infection, we therefore made use of catheters, jackets, and tethers for intravenous (IV) dosing and blood collection, which minimized the requirement for repeated anesthesia events. When MARV infection was treated with IV favipiravir, five of six animals (83%) survived infection, while all untreated NHPs succumbed. An accompanying report presents the results of favipiravir treatment of EBOV infection in mice.
A Portable Inhalation System for Personal Exposure to Ozone (1996)

A low-cost portable inhalation system was developed for exposing an individual subject to 60-600 parts per billion of ozone in a 30-l clear-plastic head dome. The inhalation system had the following novel features: a canister vacuum cleaner that supplied room air without the need for precleaning or humidification; a 7% oxygen-in-nitrogen feed to a commercial ultraviolet ozonator that avoided an excess production of ozone; a compact inline mixer that assured homogeneous mixing of the 200-300 liters per minute room air supply with the 0.5-1.0 liters per minute of ozonated gas flow, positioning of gas inlet and exhaust hoses on the head dome that provided fresh gas delivery in the vicinity of the mouth; a quick-disconnect neck seal that allowed rapid donning of the head dome by the subject, and mounting of most system components on a small mobile cart. Temperature, humidity, and ozone and carbon dioxide concentrations were measured inside the dome while a subject exercised on a bicycle ergometer. An air flow of 200 liters per minute between rest and light exercise created a suitable microenvironment in the dome. During moderate and heavy exercise, however, a higher flow of 300 liters per minute should be used to suppress the build-up of carbon dioxide and humidity.
Integrated Mode-Locked Lasers in a CMOS-Compatible Silicon Photonic Platform (2015)

Integrated components necessary for a mode-locked laser are demonstrated on a platform that allows for monolithic integration with active silicon photonics and CMOS circuitry. CW lasing and Q-switched mode-locking are observed in the full structures.
Unusual cerium(III) chloride‐promoted reactions of alkenyl grignard reagents or alkenyl‐lithiums with 1,3‐diphenyl‐2‐propanone: Formation and trapping of diorganometallic species (1995)

Abstract Treatment of vinylmagnesium chloride with anhydrous cerium(III) chloride in tetrahydrofuran at −20°C, followed by reaction with 1,3‐diphenyl‐2‐propanone, afforded ( Z )‐2,7‐dibenzyl 1,8‐diphenyl‐4‐octene‐2,7‐diol and ( Z )‐2,7‐dibenzyl‐1,8‐diphenyl‐4,6‐octadien‐2‐ol in 19% and 9% yield, respectively. Isopropenyl‐magnesium bromide underwent trimerization on treatment with cerium chloride at 20°C, and the subsequent reaction with the same ketone provided ( Z , Z )‐2,9‐dibenzyl‐4,5,7‐trimethyl‐1,10‐diphenyl‐4,6‐decadiene‐2, 9‐diol in 22% yield. Under similar conditions, the reaction of 2‐methyl‐1‐propenylmagnesium bromide provided ( Z )‐2,6‐dibenzyl‐4‐methyl‐1,7‐diphenyl‐3,5‐heptadien‐2‐ol in 7% yield. Vinyl‐lithium and isopropenyl‐lithium were also subjected to dimerization by the action of cerium chloride, and the generated diorganometallic species were trapped by 1,3‐diphenyl‐2‐propanone.
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine (2020)

A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older. Safety over a median of 2 months was similar to that of other viral vaccines. (Funded by BioNTech and Pfizer; ClinicalTrials.gov number, NCT04368728.).