gebhart/patrepeval huggingface dataset:
13.3: Novel Surface Conduction Electron Emitter (SCE) Nanogaps for Field Emission Displays (2008)

Abstract A novel nanometer scaled gap in palladium thin film strip was prepared by hydrogen absorption under high pressure conditions, and implemented in the fabrication of the surface conduction electron emitter (SCE) for flat panel display applications. The lattice constant increase in the Pd due to the phase transformation from the α‐phase to the β‐phase after hydrogen absorption, a large compressive stress occurred to the Pd thin film. with a proper geometric arrangement of the Pd/Pt/Ti emitter electrode of the SCE structure, a single nanogap per SCE device was prepared. Finite element analysis was carried out to study the hydrostatic stress distribution in the thin film emitter structure after Pd hydrogenation, and thereby the optimized thickness of thin film electrodes of the emitter was determined for the nanogap fabrication. The novel SCE emitter had an inclined protrusion structure on the cathode, which greatly enhance the local electrical field and improve electron beam focusing. The experimental measurement and theoretical analysis show that field emission properties of the novel SCE are superior to conventional SCE with the coplanar cathode.
Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity (2022)

Abstract The inhibition of tumor necrosis factor-α (TNFα) trimer formation renders it inactive for binding to its receptors thus mitigating the vicious cycle of inflammation. We designed a peptide (PIYLGGVFQ) that simulates a sequence strand of human TNFα monomer using a series of in silico methods, such as active site finding (Acsite), protein-protein interaction (PPI), docking studies (GOLD and Modeller) followed by molecular dynamics (MD) simulation studies. The MD studies confirmed the intermolecular interaction of the peptide with the TNFα. Fluorescence-activated cell sorting (FACS) and fluorescence microscopy revealed that the peptide effectively inhibited the binding of TNF to the cell surface receptors. The cell culture assays showed that the peptide significantly inhibited the TNFα-mediated cell death. In addition, the nuclear translocation of the nuclear factor kappa B (NFκB) was significantly suppressed in the peptide-treated A549 cells as observed in immunofluorescence and gel mobility-shift assays. Furthermore, peptide protected against joint damage in collagen-induced arthritis (CIA) mouse model as revealed in the microfocal-CT scans. In conclusion, this TNFα antagonist would be useful for the prevention and repair of inflammatory bone destruction and subsequent loss in the mouse model of CIA as well as human rheumatoid arthritis (RA) patients. This calls upon further clinical investigation to utilize its potential effect as an anti-arthritic drug.
Volume holographic pulse shaping (1992)

Volume holograms for subpicosecond pulse shaping are described. Experimental results with a camphorquinonedoped plastic hologram probed by a colliding-pulse mode-locked laser are presented. We observe a 2-THz beat frequency in the diffracted pulse.
A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration (2014)

To address the challenges associated with defined control over matrix properties in 3D cell culture systems, we employed a peptide functionalized poly(ethylene glycol) (PEG) hydrogel matrix in which mechanical modulus and adhesive properties were tuned. An HT-1080 human fibrosarcoma cell line was chosen as a model for probing matrix influences on tumor cell migration using the PEG hydrogel platform. HT-1080 speed varied with a complex dependence on both matrix modulus and Cys-Arg-Gly-Asp-Ser (CRGDS) adhesion ligand concentration, with regimes in which motility increased, decreased, or was minimally altered being observed. We further investigated cell motility by forming matrix interfaces that mimic aspects of tissue boundaries that might be encountered during invasion by taking advantage of the spatial control of the thiol-ene photochemistry to form patterned regions of low and high cross-linking densities. HT-1080s in 100 Pa regions of patterned PEG hydrogels tended to reverse direction or aggregate at the interface when they encountered a 360 Pa boundary. In contrast, HT-1080s were apparently unimpeded when migrating from the stiff to the soft regions of PEG peptide hydrogels, which may indicate that cells are capable of "reverse durotaxis" within at least some matrix regimes. Taken together, our results identified matrix regimes in which HT-1080 motility was both positively and negatively influenced by cell adhesion or matrix modulus.
Carbohydrate-based enolates as heterocyclic building blocks. Synthesis of the herbicidin glycoside (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbohydrate-based enolates as heterocyclic building blocks. Synthesis of the herbicidin glycosideNicholas J. Newcombe, Mary F. Mahon, Kieran C. Molloy, David Alker, and Timothy GallagherCite this: J. Am. Chem. Soc. 1993, 115, 14, 6430–6431Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://doi.org/10.1021/ja00067a076RIGHTS & PERMISSIONSArticle Views343Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (273 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Retinal and Choroidal Findings in Oxalate Retinopathy Using EDI-OCT (2012)

A 55-year-old woman with extensive retinal crystalline deposition secondary to primary hyperoxaluria presented with bilateral loss of vision secondary to oxalate retinopathy. Enhanced depth imaging optical coherence tomography revealed intraretinal, subretinal, and intraretinal and subretinal pigment epithelium, and choroidal focal hyperreflective structures consistent with both neurosensory and uveal deposition of oxalate crystals. Serial optical coherence tomography revealed continued crystalline deposition with progressive retinal atrophy.
Session 14: Characterization, reliability, and yield - ESD/memory reliability (2008)

The ESD and non-volatile memory reliability session focuses on recent developments in ESD and Latchup protection methodology and reliability challenges for NVMs. The invited talk on the ESD qualification for 45 nm and beyond provides first hand information about the vivid discussion on ESD target levels started in the electronics industry. For 22 nm and beyond FINFET technology might become an option which requires an appropriate ESD protection as discussed by the second paper. The growing awareness of a latchup optimized design is addressed by the study of guard ring interactions and their effect on CMOS Latchup resilience. In the second part of the session, Non-Volatile Memory reliability aspects will be presented, starting with a new method to evaluate the trapped charge distributions in SONOS-type devices. Retention implications will be discussed in this presentation, as well as in the following one, focused on the statistical investigation of leakage current in floating gate cells with a high-k interpoly dielectric. In the last paper of this session, evidence will be provided for bit flips produced in Flash memories by the atmospheric neutrons deriving as ground level byproducts of cosmic ions.
Hybrid Organic-Inorganic Photodriven Nanoimpellers for Drug Release (2012)

Mesostructured SiO2 films functionalized with the azo-chromophore Disperse Red 1 were synthesized by sol-gel method. The mesostructured long-range order in the films was determined by X-Ray Diffraction. The azo-chromophores in the films work as nano-impellers through their photo-induced trans-cis reversible isomerization. When the films are doped, they are able to control the release of the dopant by all-optical processes. We used the dye laser Rhodamine 6G as dopant, its very distinctive luminescence around 550 nm allows to follow the release. Polarized green and infrared laser light were used as pump sources to direct the movement of the nano-impellers. 299 nm light was used as a probe to induce the Rhodamine 6G luminescence, which was measured as function of the pumping time with a photomultiplier coupled to a monochromator. The results corresponding to the green and to the infrared pumping sources are compared in order to determine the feasibility to photo-control the nano-impellers movement through a two-photon absorption process.
DSC analyses of bound water in the microdomains of interpolymer complexes (1983)

Abstract Bound water in polymers and polymer complexes was analyzed quantitatively by means of differential scanning calorimetry in a temperature range from −50 to + 20°C. The water molecules were bound to the polymer chains with different strength, as reflected in a shift of the melting temperature. The existence of non‐freezing water was also confirmed from the relation between the incorporated water content and the heat of fusion. About 0,3 to 0,6 g of water was revealed to exist as non‐freezing water in 1,0 g of the polyelectrolyte complexes. This amount varied with the structure of the polymers investigated. The melting temperature of bound water increases with increasing water content of the component polymers or polymer complexes. The number of bound water molecules per monomeric unit of the polymer is about 3 to 7, and decreases by complex formation. It is speculated from the obtained results that desolvation is accompanied with complex formation, but the solvated state is maintained largely in spite of a drastic decrease in segmental motion of the polymer chains in the polymer complexes.
Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α (2007)

IFN-gamma induces its immunoregulatory activities by activating genes mainly through the Jak-STAT signaling pathway. Here we show that what was considered to be intrinsic IFN-gamma activities depend largely on the basal level of NF-kappaB, which is maintained by constitutively expressed IL-1alpha. The IL-1 receptor antagonist and antibodies to IL-1alpha, but not to IL-1beta, inhibited the antiviral activity of IFN-gamma by 90%, whereas no inhibition of type I IFN activity was observed. Similarly, the induction of many genes by IFN-gamma, including HLA-DR, ICAM-1, IL-18BP, and genes mediating its antiviral activity, greatly depended on basal IL-1alpha. Furthermore, IFN-gamma induced serum IL-18 binding protein in wild-type mice but not in IL-1alpha/beta double-deficient mice. Thus, constitutively expressed IL-1alpha is critical for numerous IFN-gamma activities.
Clinical management and outcomes of patients with Hermansky-Pudlak syndrome pulmonary fibrosis evaluated for lung transplantation (2018)

Pulmonary fibrosis is a progressive, fatal manifestation of Hermansky-Pudlak syndrome (HPS). Some patients with advanced HPS pulmonary fibrosis undergo lung transplantation despite their disease-associated bleeding tendency; others die while awaiting donor organs. The objective of this study is to determine the clinical management and outcomes of a cohort with advanced HPS pulmonary fibrosis who were evaluated for lung transplantation. Six patients with HPS-1 pulmonary fibrosis were evaluated at the National Institutes of Health Clinical Center and one of two regional lung transplant centers. Their median age was 41.5 years pre-transplant. Three of six patients died without receiving a lung transplant. One of these was referred with end-stage pulmonary fibrosis and died before a donor organ became available, and donor organs were not identified for two other patients sensitized from prior blood product transfusions. Three of six patients received bilateral lung transplants; they did not have a history of excessive bleeding. One patient received peri-operative desmopressin, one was transfused with intra-operative platelets, and one received extracorporeal membrane oxygenation and intra-operative prothrombin complex concentrate, platelet transfusion, and desmopressin. One transplant recipient experienced acute rejection that responded to pulsed steroids. No evidence of chronic lung allograft dysfunction or recurrence of HPS pulmonary fibrosis was detected up to 6 years post-transplant in these three lung transplant recipients. In conclusion, lung transplantation and extracorporeal membrane oxygenation are viable options for patients with HPS pulmonary fibrosis. Alloimmunization in HPS patients is an important and potentially preventable barrier to lung transplantation; interventions to limit alloimmunization should be implemented in HPS patients at risk of pulmonary fibrosis to optimize their candidacy for future lung transplants.
Molecular Discrimination of Type-I over Type-II Methionyl Aminopeptidases (2005)

Two residues that are conserved in type-I methionyl aminopeptidases (MetAPs) but are absent in all type-II MetAPs are the cysteine residues (Escherichia coli MetAP-I: C59 and C70) that reside at the back of the substrate recognition pocket. These Cys residues are 4.4 A apart and do not form a disulfide bond. Since bacteria and fungi contain only type-I MetAPs while all human cells contain both type-I and type-II MetAPs, type-I MetAPs represent a novel antibiotic/antifungal target if type-I MetAPs can be specifically targeted over type-II. Based on reaction of the thiol-specific binding reagent 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) with the type-I MetAP from E. coli and the type-II MetAP from Pyrococcus furiosus, the type-I MetAP can be selectively inhibited. Verification that DTNB covalently binds to C59 in EcMetAP-I was obtained by mass spectrometry (MS) from reaction of DTNB with the C59A and C70A mutant EcMetAP-I enzymes. In addition, two inhibitors of EcMetAP-I, 5-iodopentaphosphonic acid (1) and 6-phosphonohexanoic acid (2), were designed and synthesized. The first was designed as a selective-C59 binding reagent while the second was designed as a simple competitive inhibitor of EcMetAP. Indeed, inhibitor 1 forms a covalent interaction with C59 based on activity assays and MS measurements, while 2 does not. These data indicate that type-I MetAPs can be selectively targeted over type-II MetAPs, suggesting that type-I MetAPs represent a new enzymatic target for antibacterial or antifungal agents.
TRAUMATIC BRAIN INJURY (1999)

s Of Papers To Be Presented At The Fifty-Ninth Annual Meeting Of The American Association For The Surgery Of Trauma; Marriott Copley Place Hotel, Boston, Massachusetts; September 16-18, 1999
Optimizing repulsive lorentz forces for a levitating induction cooker (2014)

In this paper we study a novel way of induction cooking. Traditionally, an alternating magnetic field is used to induce currents in a ferromagnetic pan to heat foods. We use non-ferromagnetic materials and optimize the design for high repulsive forces in order to levitate the pan while simultaneously heating it and its contents. Our approach is simulation-based to study the influence of different parameters and to perform multidimensional analyses for high force versus power or loss goals. Finally, an experimental prototype has been realized and successfully operated.
A novel role of the C-terminus of b0,+AT in the ER–Golgi trafficking of the rBAT–b0,+AT heterodimeric amino acid transporter (2008)

The heterodimeric complex composed of rBAT (related to b(0,+) amino acid transporter), a single-membrane-spanning glycosylated heavy chain, and b(0,+)AT, a putative 12-membrane-spanning non-glycosylated light chain, is an amino acid transporter that mediates the activity of system b(0,+), a major apical transport system for cystine and dibasic amino acids in renal proximal tubule and small intestine. The C-terminus of b(0,+)AT has been proposed to play an important role in the functional expression of the heterodimeric transporters. In the present study, to reveal the roles of the C-terminus, we analysed b(0,+)AT mutants whose C-termini were sequentially deleted or replaced by site-directed mutagenesis in polarized MDCKII (Madin-Darby canine kidney II), non-polarized HEK-293 (human embryonic kidney-293) and HeLa cells. Although the deletion of C-terminus of b(0,+)AT did not affect the formation of a heterodimer with rBAT, it resulted in the loss of apparent transport function, owing to the failure of the plasma-membrane targeting of rBAT-b(0,+)AT heterodimeric complex associated with incomplete glycosylation of rBAT. A motif-like sequence Val(480)-Pro(481)-Pro(482) was identified in the C-terminus of b(0,+)AT to be responsible for the C-terminus action in promoting the trafficking of rBAT-b(0,+)AT heterodimeric complex from the ER (endoplasmic reticulum) to Golgi apparatus. This is, to our knowledge, the first demonstration of the active contribution of the C-terminus of a light-chain subunit to the intracellular trafficking of heterodimeric transporters. Because the motif-like sequence Val(480)-Pro(481)-Pro(482) is well conserved among the C-termini of light-chain subunits, common regulatory mechanisms could be proposed among heterodimeric amino acid transporters.
Therapeutic treatment with cryoablation and Meriva improves T cell responses to tumor-associated antigens and is highly effective against metastatic breast cancer (TUM2P.910) (2014)

Abstract Cryoablation of tumors involve the insertion of a probe into a tumor nodule to administer tissue-ablative cold temperatures. Its mechanism of action has been attributed to the mechanical forces of crystallization, the osmotic changes due to crystallization, and the ischemic effects of microvascular injury. This leads to immunogenic tumor cell death resulting in cross presentation of tumor-associated antigens (TAA) of the cryo-killed tumor cells by antigen-presenting cells (APC) to the immune system. This in turn leads to the recruitment of TAA-specific T cells, which are powerless because of the strong immune suppression in the tumor microenvironment. We found that Meriva, a Curcumin derivate with high bioavailability, reduced immune suppression by IL-6, resulting in the activation of T cell responses to TAA Mage-b and Survivin (highly expressed by tumors and metastaess), and a nearly complete elimination of metastatic breast cancer (4T1 model) when combined with Cryoablation. In addition, the overall survival of mice that received Cryoablation and Meriva was significantly increased compared to the saline group. Our results demonstrate that Meriva is a potent agent to reduce immune suppression by IL-6 and to stimulate TAA-specific T cells in a tumor microenvironment. Moreover, Meriva might be useful in other combination therapies that induce immunogenic tumor cell death like adriamycin or radiation, or with vaccines that are hampered by immune suppression in the TME.
Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction (2002)

Renal cell carcinoma (RCC) infiltrating lymphocytes (TILs) express killer cell immunoglobulinlike receptors (KIRs) that inhibit the antitumor CD8(+) T-cell lysis. In the present study, to better examine the functional consequences of KIR engagement on cytotoxic T lymphocyte (CTL)/tumor interaction, we have investigated the influence of KIR CD158a on early steps of T-cell activation. We show that coengagement of T-cell receptor (TCR) and CD158a by tumor cells inhibited tyrosine phosphorylation of early signaling proteins ZAP-70 and LAT, lipid raft coalescence, and TCR/CD3 accumulation at the CTL/tumor cell interface. In addition, the guanine exchange factor Vav was not phosphorylated, and no actin cytoskeleton rearrangement was observed. Our data indicate a role of KIR CD158a in the dynamic events induced by TCR triggering, preventing CTL membrane reorganization, and subsequent completion of CTL activation program. Accordingly, the expression of CD158 by TILs may favor tumor cell escape to the immune response.
ChemInform Abstract: Recent Advances in the Synthesis of Diketopiperazines. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Strategies for developing robust teamsmanship in the context of design education for product development: A progress report (2002)

A conceptual model that provides a framework for developing strategies to improve the performance of student teams has been developed. The model is dynamic and covers the time-dependent states that are essential for the proposed criterial of successful team-based design project experience for students. The states of design progress, team development, and knowledge acquisition can be moved to desired values at project conclusion by measurement and comparison with desired values. The main energy for moving the states is derived from the team efforts that are internally directed through the primary, single-loop feedback structure. Secondary energy is derived from coaches and instructors through interventions that are directed as part of an external secondary, or double-loop structure. Interventions include instruction in the whole process and specification of a design activity schedule. This aggressive activity schedule sets up an environment that provides tension for the team to move the states toward improved values.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Theory of Raman scattering by molecules adsorbed on electrode surfaces (1978)

In this work, we provide a simple classical model to explain the enormous intensity enhancement observed for Raman scattering from molecules adsorbed on electrode surfaces. It is proposed that the origin of the intensity enhancement arises from very large changes in the polarizability derivative with respect to a normal coordinate, by virtue of the image field at the admolecule. A qualitative discussion of the role of adsorbed counter ions is presented. We tentatively propose that the dependence of the intensity enhancement on counter ion concentration may be understood in terms of nearest neighbor dipole–dipole stabilization of surface clusters of counter ions with the adsorbate molecule. We also discuss some limitations of the classical model, and propose some further experiments that may lead to clarification of the ideas presented in this work.
Design Of High Quality Miniature Bioelectric Amplifiers In Thick Film Technology (2005)

A miniature universal front-end for analog signal acquisition in bioelectric measurements is resented. Use is made of thick film technology I ecause in this technique the specifications can be adjusted b passive components only and the best commercia{ ly avai 1 able semi conductor devices can be applied. Methods to obtain low noise and low power properties are discussed.