gebhart/patrepeval huggingface dataset:
Perinadine A, a Novel Tetracyclic Alkaloid from Marine-Derived Fungus Penicillium citrinum (2005)

A novel tetracyclic alkaloid, perinadine A (1), was isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from the gastrointestine of a marine fish, and the structure was elucidated on the basis of spectroscopic data including 2D NMR spectra. Biogenetically, perinadine A (1) may be derived from citrinin (4), a well-known mycotoxin, and a scalusamide A-type pyrrolidine alkaloid.
EXTRACTION OF THE INHERENT NATURE OF WIND USING WAVELETS (2014)

Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.
Microscopy of the morphology in low styrene emission glass fiber/unsaturated polyester laminates (1999)

Low styrene emission (LSE) unsaturated polyester resins are of interest in the context of increasing environmental concerns in the society. LSE resins have been developed to decrease styrene emission during the processing of composites based on unsaturated polyesters. In this article we applied a microscopy methodology to study morphology effects in laminates based on LSE polyesters. The study connects to the longer term objective to improve the understanding of how additives reduce styrene emission without imparting delamination resistance in composite laminates based on LSE polyesters. The major morphology differences between laminates made from different polyesters are discussed, including birefringent layers present as an interphase between different layers. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 1555–1562, 1999
Adaptive feedback linearization using multivariable spline functions (2005)

This paper presents a method to construct an adaptive feedback-linearizing control law using multivariable spline functions. Unlike the majority of results in adaptive control, the plant is not required to be linearly parameterized. Computational complexity issues are discussed in detail. Of particular relevance is the extremely simple form that the regressor assumes. A numerical example illustrates the controller construction and performance.
Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells (2010)

Glycoprotein isolated from Laminaria japonica (LJGP) is known to exhibit significant cytotoxic activity against human cancer cells; however, the mechanisms of its cytoxicity are poorly understood. In this study, we investigated further possible mechanisms by which LJGP exerts its anti-cancer action in cultured human gastric carcinoma AGS cells. LJGP treatment of AGS cells resulted in inhibition of growth and induction of apoptosis in a time- and concentration-dependent manner, as determined by MTT assay, fluorescence microscopy, and flow cytometry analysis. The increase in apoptosis was associated with up-regulation of pro-apoptotic Bax expression, down-regulation of anti-apoptotic Bcl-2 and IAP family members, and activation of caspase-3 and -9. LJGP treatment markedly down-regulated the activity of telomerase and expression of human telomerase reverse transcriptase, a main determinant of telomerase enzymatic activity, with inhibition of Sp1 and c-Myc expression in a concentration-dependent manner. Furthermore, LJGP treatment also caused a progressive decrease in the expression levels of cyclooxygenase (COX)-2 without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 synthesis. These results provide important new insights into the possible molecular mechanisms of the anti-cancer activity of LJGP.
A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure (2020)

A p-isothiocyanate phenylalanine\nmutant of the homodimeric protein\nhomoserine o-succinyltransferase (MetA) was isolated in a temperature\ndependent selection from a library of &lt;i&gt;metA&lt;/i&gt; mutants\ncontaining noncanonical amino acids. This mutant protein has a dramatic\nincrease of 24 °C in thermal stability compared to the wild type\nprotein. Peptide mapping experiments revealed that the isothiocyanate\ngroup forms a thiourea cross-link to the N terminal proline of the\nother monomer, despite the two positions being &gt;30 Å apart\nin\nthe X-ray crystal structure of the wild type protein. These results\nshow that an expanded set of building blocks beyond the canonical\n20 amino acids can lead to significant changes in the properties of\nproteins.
Reflective afocal broadband adaptive optics scanning ophthalmoscope (2011)

A broadband adaptive optics scanning ophthalmoscope (BAOSO) consisting of four afocal telescopes, formed by pairs of off-axis spherical mirrors in a non-planar arrangement, is presented. The non-planar folding of the telescopes is used to simultaneously reduce pupil and image plane astigmatism. The former improves the adaptive optics performance by reducing the root-mean-square (RMS) of the wavefront and the beam wandering due to optical scanning. The latter provides diffraction limited performance over a 3 diopter (D) vergence range. This vergence range allows for the use of any broadband light source(s) in the 450-850 nm wavelength range to simultaneously image any combination of retinal layers. Imaging modalities that could benefit from such a large vergence range are optical coherence tomography (OCT), multi- and hyper-spectral imaging, single- and multi-photon fluorescence. The benefits of the non-planar telescopes in the BAOSO are illustrated by resolving the human foveal photoreceptor mosaic in reflectance using two different superluminescent diodes with 680 and 796 nm peak wavelengths, reaching the eye with a vergence of 0.76 D relative to each other.
P2‐167: Alzheimer disease tangles and threads display multiple tau phosphorylation sites (2008)

Insoluble tau accumulations are characteristic of AD and many other tauopathies. They occur primarily in the form of neurofibrillary tangles (NFTs) and threads. Tau is known to be phosphorylated in these abnormal accumulations but it is still uncertain as to which phosphokinases are primarily involved. To explore this question, we epitope mapped a series of anti-tau antibodies directed at specific sites of phosphorylation and compared their ability to detect NFTs and threads in paraformaldehyde fixed sections of AD brain. We synthesized on cellulose membranes by robotic methods, arrays of 11-mer peptides covering specific sequences in tau where each peptide was shifted by one amino acid. Matching arrays were prepared where one array was phosphorylated at key threonine and serine sites and the other non phosphorylated. We found that specific antibodies raised against peptides phosphorylated at threonine 181, 205, 212 and 217 and at serine 198, 214, and 396 each recognized the specific phosphorylated peptides but not the corresponding non phosphorylated peptides. By immunohistochemistry, each antibody strongly recognized both NFTs and threads in AD tissue with no apparent qualitative differences. We conclude that each of these threonine and serine sites of tau is abundantly phosphorylated in the threads and NFTs that develop in AD brain. The phosphokinase GSK3b has been reported to phosphorylate recombinant tau at each of these sites and the phosphokinase cdk5 has been reported to phosphorylated the same sites except for serine 198. These phosphokinases could be playing a key role in the development of tau pathology in AD. Supported by the Pacific Alzheimer Research Foundation.
Solid‐phase peptide synthesis: a silver anniversary report* (1987)

It has been a quarter of a century since Merrifield's initial report on solid-phase peptide synthesis. The field has matured significantly in recent years with a better understanding of the underlying chemistry. This is reflected by new, milder orthogonal protection schemes and more efficient coupling methods, some of which have been incorporated into automated systems. Advances in purification, especially high performance liquid chromatography, have had a major impact. The efficacy of these improvements has been demonstrated by an impressive litany of applications to biological problems.
HIV-1 Vaccine Development (2015)

A thorough and up-to-date review of vaccinology research in age of omics technologies. Part I covers the key innovations that are dramatically changing the field. In Part II chapters are focused on vaccines for diseases for which current treatment is ineffective. Essential reading for everyone working in vaccine R and D.
Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro (2019)

The FDA approval of two anti-HER2 monoclonal antibodies, trastuzumab and pertuzumab, and an antibody-drug conjugate, trastuzumab emtansine, has transformed clinical practice for HER2-positive cancers. However, not all patients respond to therapy, and the majority of responders eventually develop resistance. In addition, cardiotoxicity is a major safety concern for their clinical use. Thus, there remains a need for the discovery and development of novel classes of HER2-targeted therapeutics with high efficacy and specificity. In this study, we report the identification and characterization of fully human single-domain antibodies (dAbs) targeting HER2 epitopes that are highly conserved among various species and non-overlapping with those of trastuzumab and pertuzumab. An Fc-fusion protein of the best binder demonstrated much higher inhibitory activity against HER2-amplified human breast cancer cell lines than trastuzumab and pertuzumab. Unlike the latter, however, it did not have an effect on gastric and ovarian cancer cell lines with HER2 overexpression. The dAb-Fc fusion protein showed poor pharmacokinetics in mice, thus limiting its potential for therapeutic use. It could be useful as an agent for the exploration of functionally important conserved structures on HER2 with implications for the design of novel therapeutics and elucidation of mechanisms of HER2-mediated tumorigenesis.
To AND or To OR: How shall the fusion center rule in energy-constrained cognitive radio networks? (2014)

Distributed spectrum sensing enhances the detection reliability of a cognitive radio network. However, this comes at the price of a higher energy consumption. To solve this problem, a combined censoring and sleeping scheme is considered where the cognitive radios switch off their sensing module with a specific sleeping rate in each sensing period. The awake cognitive radios send their local decisions to the fusion center only if it is deemed to be informative. The fusion center either employs the OR or the AND rule to make the final decision about the presence or absence of the primary user. This paper investigates which rule performs better in terms of energy efficiency under various conditions. The underlying sensing parameters are derived by minimizing the maximum average energy consumption per sensor subject to a constraint on the probabilities of false alarm and detection. This way, it can be ensured that the spectrum opportunities are utilized efficiently while the primary users are not interfered with. A case study based on IEEE 802.15.4/ZigBee is considered for performance evaluation. It is shown that significant energy savings can be obtained by employing combined censoring and sleeping.
ChemInform Abstract: Doubly Cyclopalladated Complexes of N,N,N′,N′‐Tetraethylbenzene‐1,3‐bis(methylamine). (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Full-wave simulation of enhanced outcoupling of organic light-emitting devices with an embedded low-index grid (2009)

Enhancement of light outcoupling into substrate modes by a grid of low-refractive-index material embedded into the organic layer of an organic light-emitting device (OLED) is analyzed using full-wave electromagnetic simulations. The low-index grid (LIG) redirects modes normally trapped within the high-index organic and indium tin oxide layers (waveguide modes) into the substrate where they can be further extracted into free space using methods such as microlens arrays or roughened surfaces. This increases the external quantum and power efficiencies without affecting the electroluminescent spectrum. The dependence on grid geometry, dimensions, and refractive index is explored to optimize the structure. Simulations show that up to 50% more light can be extracted from the high-index region using an ultralow-index (n=1.03) grid than a conventional device, and provided efficient substrate-to-air outcoupling, the external quantum efficiencies of LIG OLEDs can reach &amp;gt;50%.
Measurement of the lifetime of excited-state electron bubbles in superfluid helium (2005)

We report on the measurement of the lifetime of bubbles in superfluid helium that contain an electron in the $1P$ state. The $1P$ bubbles are produced by laser excitation of ground-state bubbles, and are detected by ultrasonic cavitation. Our measurements show that the lifetime of these excited bubbles is much less than the calculated lifetime for radiative decay and, hence, is determined by a nonradiative mechanism.
Synthesis of a Conformationally Restricted Cyclic Phosphate Analog of Inositol Triphosphate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a Conformationally Restricted Cyclic Phosphate Analog of Inositol TriphosphateAndrew M. Riley and Barry V. L. PotterCite this: J. Org. Chem. 1995, 60, 16, 4970–4971Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/jo00121a006https://doi.org/10.1021/jo00121a006research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
How to find a battleship (1989)

Abstract Consider a “sea” of M squares which contains (at some unknown location) a “battleship” of K squares. Both the sea and the battleship can assume any rectangular shape. Our goal is to find the battleship by probing at least one of its squares. In this paper we describe a deterministic strategy for this problem which is guaranteed to locate the battleship in at most c 1 M/K probes, where c 1 ≈︁ 3.065.
Blood supply of pulmonary metastases (1987)

There is a widely held belief that metastases to the lung (like primary lung tumors) are supplied by the bronchial arteries and that pulmonary neovascularization does not occur. In 17 human lungs, we have demonstrated, both in vitro and in vivo, pulmonary circulation to metastases. We have confirmed this in a series of animal studies in which we implanted tumors of various histologies into rats' tails and induced metastases from these tumors into the lungs. Forty-eight percent of these metastases had an entirely pulmonary circulation, 36% a primarily pulmonary circulation with a small bronchial component, and only 16% of metastases, located in the central one third of the lung, had an exclusively bronchial circulation. We have now shown that these supplying pulmonary vessels to metastases can be clearly demonstrated on thin-section computed tomography of the lungs. This may prove to be a helpful, noninterventional diagnostic criterion for distinguishing a primary from a metastatic lesion.
X-ray reflectivity measurement of interdiffusion in metallic multilayers during rapid heating (2017)

A technique for measuring interdiffusion in multilayer materials during rapid heating using X-ray reflectivity is described. In this technique the sample is bent to achieve a range of incident angles simultaneously, and the scattered intensity is recorded on a fast high-dynamic-range mixed-mode pixel array detector. Heating of the multilayer is achieved by electrical resistive heating of the silicon substrate, monitored by an infrared pyrometer. As an example, reflectivity data from Al/Ni heated at rates up to 200 K s<sup>-1</sup> are presented. At short times the interdiffusion coefficient can be determined from the rate of decay of the reflectivity peaks, and it is shown that the activation energy for interdiffusion is consistent with a grain boundary diffusion mechanism. At longer times the simple analysis no longer applies because the evolution of the reflectivity pattern is complicated by other processes, such as nucleation and growth of intermetallic phases.
(η 5 ‐Cyclopentadienyl)Diruthenium Complexes (1989)

This chapter contains sections titled: Tetracarbonylbis(η5-cyclopentadienyl)diruthenium μ-Carbonyl-carbonylbis(η5-cyclopentadienyl)(μ-3-oxol,2-diphenyl-1-η:-1,2,3-η-1-propen-1,3-diyl)diruthenium(Ru-Ru), [Ru2(CO)(μ-CO){μ-η1:η3-C(O)C2Ph2}(η5C5H5)2](I) μ-Carbonyl-μ-methylene-bis[carbonyl(η5-cyclopentadienyl)ruthenium] μ-Carbonyl-μ-ethenylidene-bis[carbonyl(η5-cyclopentadienyl)ruthenium] μ-Carbonyl-μ-ethenylidene-bis[carbonyl(η5-cyclopentadienyl)ruthenium]Tetrafluoroborate μ-Carbonyl-μ-ethenylidene-bis[carbonyl(η5-cyclopentadienyl)ruthenium]
Doppler Aided Tracking Loops for SRGPS Integrity Monitoring (2003)

This paper evaluates the potential benefit of using Doppler aided carrier tracking loops as part of the JPALS integrity monitoring scheme. It is envisioned that Doppler aided carrier tracking loops will be used as part of the radio frequency spatial environment estimator. Using a frequency domain performance analysis of a third order Costas loop the contributions to the total phase error from local oscillator instability, satellite clock error, platform dynamic stress and platform vibration are quantified. The benefit of Doppler aiding to mitigate phase errors due to platform dynamic stress is quantified. The performance analysis shows that without external Doppler aiding the minimum carrier to-noise ratio (C/N0) that can be tracked is approximately 26 dB-Hz. The achievable tracking loop noise bandwidth at this C/N0 is approximately 10 Hz. Removing platform dynamics using an estimate of carrier Doppler provides an approximately 5 dB-Hz margin allowing signals with C/N0 as low as 21 dB-Hz to be tracked. This is achieved by narrowing the carrier loop noise bandwidth to 1 Hz. Some of the error models and analysis results are confirmed by postprocessing experimental data. Finally, the implications of these results on JPALS integrity monitoring are discussed.
New Fluorescent Porphyrins with High Two-Photon Absorption Cross-Sections Designed for Oxygen-Sensitization: Impact of Changing the Connectors in the Peripheral Arms (2023)

In the continuation of our sustained interest in porphyrin-based dendrimers and their use as luminescent photosensitizers for two-photon photodynamic therapy (2P-PDT), we wondered about the effect of changing the connectors in our macromolecular structures. We also wanted to initiate preliminary studies on meso-tetraarylporphyrins decorated with more electron-releasing arms. Thus, various meso-tetrafluorenylporphyrin-cored star-shaped and dendrimeric derivatives have been synthesized and characterized, as well as their zinc(II) complexes. In the new dendrimeric derivatives, the peripheral fluorenyl units of the dendrons are linked to the inner core either by N-phenylcarbazole (CCbz) or triphenylamine (CTpa) connectors instead of the more classic 1,3,5-phenylene (CPh) linkers previously used by us. Selected linear and non-linear optical (LO and NLO) properties were then determined for these compounds via absorption or emission studies and by two-photon excited fluorescence (TPEF) measurements. It was found that the CCbz-containing dendrimer, which has the most rigid structure, exhibits a significantly lower two-photon absorption (2PA) cross-section than its CTpa analog, presenting a more flexible structure while rather similar luminescence and singlet oxygen activation quantum yields are found for both. The origin of this unexpected discrepancy is briefly discussed based on our photophysical data. It is then demonstrated that the latter dendrimer also outperforms several closely related dendrimers in terms of 2PA action cross-section and 2PA-oxygen sensitization, making its molecular architecture quite appealing for developing new 2PA photosensitizers suited to theranostic uses.
Molecular Investigation of Iron–Sulfur Cluster Assembly Scaffolds under Stress (2014)

Fe/S biosynthesis is controlled in Escherichia coli by two machineries, the housekeeping ISC machinery and the SUF system that is functional under stress conditions. Despite many in vivo studies showing that SUF is more adapted for Fe/S assembly under stress, no molecular data supporting this concept have been provided so far. This work focuses on molecular studies of key actors in Fe/S assembly, the SufB and IscU scaffolds under oxidative stress and iron limitation. We show that the IscU Fe2S2 cluster is less stable than the SufB Fe2S2 cluster in the presence of hydrogen peroxide, oxygen, and an iron chelator.