gebhart/patrepeval huggingface dataset:
Prediction of hemoglobin levels in individual hemodialysis patients by means of a mathematical model of erythropoiesis (2018)

Anemia commonly occurs in people with chronic kidney disease (CKD) and is associated with poor clinical outcomes. The management of patients with anemia in CKD is challenging, due to its severity, frequent hypo-responsiveness to treatment with erythropoiesis stimulating agents (ESA) and common hemoglobin cycling. Nonlinear dose-response curves and long delays in the effect of treatment on red blood cell population size complicate predictions of hemoglobin (Hgb) levels in individual patients. A comprehensive physiology based mathematical model for erythropoiesis was adapted individually to 60 hemodialysis patients treated with ESAs by identifying physiologically meaningful key model parameters from temporal Hgb data. Crit-Line® III monitors provided non-invasive Hgb measurements for every hemodialysis treatment. We used Hgb data during a 150-day baseline period together to estimate a patient's individual red blood cell lifespan, effects of the ESA on proliferation of red cell progenitor cells, endogenous erythropoietin production and ESA half-life. Estimated patient specific parameters showed excellent alignment with previously conducted clinical studies in hemodialysis patients. Further, the model qualitatively and quantitatively reflected empirical hemoglobin dynamics in demographically, anthropometrically and clinically diverse patients and accurately predicted the Hgb response to ESA therapy in individual patients for up to 21 weeks. The findings suggest that estimated model parameters can be used as a proxy for parameters that are clinically very difficult to quantify. The presented method has the potential to provide new insights into the individual pathophysiology of renal anemia and its association with clinical outcomes and can potentially be used to guide personalized anemia treatment.
Mechanical Properties and Microstructure of Mg-Zn-Y Alloys Processed by ECAE (2006)

Development of high strength I/M Mg alloys has been tried by ECAE processing. The mechanical properties and microstructure of ECAE-processed Mg97Zn1Y2 alloy with LPSO (long-periodic stacking ordered) structure were investigated. The tensile yield strength and elongation of as-cast Mg97Zn1Y2 were improved substantially by ECAE process. ECAE-processed with yield strength of 290 MPa and elongation of 22 % was obtained. The microstructure of ECAE-processed Mg97Zn1Y2 alloy consisted of refined α-Mg with the grain size around 6.5 μm and finely dispersed LPSO phase. Furthermore, the some texture was formed by ECAE process. The improved mechanical properties seem to be originated by the microstructure refinement and texture.
Some Remarks On The Smarandache Function (1995)

Remarks on a Function in the Number Theory.
SUPPLEMENTARY DATA from <i>ESR1</i> Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients (2023)

&lt;p&gt;Supplementary Methods Figure S1 ESR1 Y537SY537N and D538G probes are mutation specific. Figure S2 Patient 1 and Patient 14's plasma DNA. Table S1 Additional patient characteristics. Table S2 Primers used in this study.&lt;/p&gt;
Effect of data placement on the reliability of data storage systems (2013)

Data redundancy, in the form of replication or advanced erasure codes, is used to protect data from storage node failures. It is known that that the placement of this redundant data across storage nodes can have a significant impact on the reliability, especially for large-scale storage systems. In particular, a declustered placement of redundant data is shown to have significantly higher reliability than the traditionally-used clustered placement for many redundancy schemes. This implies that significant gains in reliability can be obtained without losing storage efficiency by choosing the declustered placement scheme. Approximate expressions for the mean time to data loss of the system in terms of the various parameters of the system are obtained by considering the shortest paths to data loss when node failures occur and rebuild processes commence. These expressions are shown to hold true for parameters of practical interest through detailed event driven simulations.
Cellular localization of complement C3 and C4 transcripts in intestinal specimens from patients with Crohn’s disease (2000)

It has been suggested that the increase in C3 and C4 levels in jejunal perfusates of patients with Crohn's disease (CD) results from local intestinal synthesis of complement. The present study evaluated the expression of these complement genes in inflamed tissues from patients with CD. Surgically resected specimens from patients with CD and control tissue obtained from subjects with adenocarcinoma of the colon were evaluated for C3 and C4 gene expression by the use of 35S-labelled anti-sense RNA probes. All tissue samples, diseased and normal tissue, expressed C4 mRNA throughout in the intestinal epithelium. C3 mRNA was not detected in epithelial cells in histologically normal tissue, but in diseased specimens there was a focal distribution of C3 mRNA in epithelial cells of the crypts, but not in villous epithelium. Focal C3 gene expression correlated with crypt abscess formation and the presence of polymorphonuclear leucocytes in the lumen of the crypts. In addition, C3 mRNA was also found in macrophages of the submucosa. These macrophages were CD68+, fusiform with faint cytoplasm and morphologically different from the large rounded lamina propria macrophages, which do not express C3 mRNA. Multinucleated giant cells did not express either C3 or C4 genes. In addition to its presence in intestinal epithelium, C4 mRNA was also expressed in mast cells, which however did not express C3 mRNA. These observations identify cells in the intestinal wall expressing complement genes and support the hypothesis that there is local regulated production of complement in the intestine of patients with CD, and subsequent complement activation may contribute to the inflammatory process.
Prevalence of secondary prosthesis use in lower limb prosthesis users (2023)

Results suggest that secondary prosthesis use for most LLPUs is limited and may differ based on users' demographic and clinical characteristics. Future research should determine how LLPUs' health-related quality-of-life outcomes are affected by access to and use of secondary prostheses.Implications for RehabilitationSecondary prostheses, including activity-specific, back-up, and shower prostheses, have the potential to improve function, mobility, and participation for people who use lower limb prostheses.Most lower limb prosthesis users do not use secondary prostheses, and access to these devices may be related to users' demographic and clinical characteristics.Rehabilitation professionals play a key role in facilitating prosthesis users' access to secondary prostheses and should advocate for those who need them.
Core Color Rendering Algorithms For High Dynamic Range Display (2017)

As is well-known, colors as they exist in the real world must be adjusted so as to look correct and pleasing when displayed on a television or cinema screen. In color science, the process of converting these “scene-referred” colors to “display-referred” colors is termed “rendering.” The Academy's ACES system is a good example of a set of open-source picture rendering algorithms. In this paper the authors, who both participated in the development of ACES, discuss the pros and cons of various rendering techniques and share the results of their latest work. Specifically we present a method of applying a tone curve that preserves color ratios and has better noise properties than earlier techniques. This algorithm has been successfully used as part of a larger parametric rendering system for HDR display. One of the nice properties of this algorithm is that it has a simple and robust inverse.
Fiber Bragg grating based dispersion compensator slope-matched for LEAF fiber (2006)

A dispersion compensator matching the spectrally-varying dispersion of LEAF fiber is presented, based on a multi-channel fiber Bragg grating that operates over the full C-band
Colometer: A real-time quality feedback system for screening colonoscopy (2012)

The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments. Further study is required to validate this approach.
Zero-watt Networked Standby: Reducing Power Consumption of Home A/V Network Systems (2013)

Energy conservation is an important global issue. The home is the third largest energy consumer, and 10% of the home energy use is standby power of home appliances. The proliferation of home networks increases the standby power. The conventional technologies for low networked standby power such as WoL require continuous AC power, as much as 0.5watts, to monitor wake-up signals. A large portion of the consumed power is due to the power loss in the AC-DC converter. Moreover, the technologies are applicable only to the specific network types such as Ethernet and IEEE802.11. We propose a solution to reduce the networked standby power down to zero virtually, regardless of the network type. For monitoring wake-up signals, the solution utilizes the pre-charged power in an ultra capacitor without using the AC power supply for almost all the time. In order to realize this idea, the solution also utilizes a unique and simple protocol dedicated only to the networked standby/wake-up functionality. This protocol enables the monitoring circuit to consume a very small amount of power, small enough for the capacitor to supply. The networked standby/wake-up functionality is easily combined with any conventional network application protocol by protocol address mapping. As one realization example of our solution, we implemented an experimental home A/V system which is integrated with an ultra low power wireless signal receiver and extended UPnP protocol. The system evaluation showed that our solution achieves the zero-watt networked standby while keeping network functionalities. Moreover, the analysis of the results based on a statistical survey shows that the practical networked standby power is 30mW when our solution is applied to a TV system, which corresponds to one seventeenth of a conventional technology, WoL. It means that our solution improves power consumption by 22% which corresponds to 1.11kg-CO2 emission reduction per year per product.
Carcinogenic hazard assessment of cobalt-containing alloys in medical devices: Review of in vivo studies (2021)

Cobalt (Co) alloys have been used for over seven decades in a wide range of medical devices, including, but not limited to, hip and knee implants, surgical tools, and vascular stents, due to their favorable biocompatibility, durability, and mechanical properties. A recent regulatory hazard classification review by the European Chemicals Agency (ECHA) resulted in the classification of metallic Co as a Class 1B Carcinogen (presumed to have carcinogenic potential for humans), primarily based on inhalation rodent carcinogenicity studies with pure metallic Co. The ECHA review did not specifically consider the carcinogenicity hazard potential of forms or routes of Co that are relevant for medical devices. The purpose of this review is to present a comprehensive assessment of the available in vivo preclinical data on the carcinogenic hazard potential of exposure to Co-containing alloys (CoCA) in medical devices by relevant routes. In vivo data were reviewed from 33 preclinical studies that examined the impact of Co exposure on local and systemic tumor incidence in rats, mice, guinea pigs, and hamsters. Across these studies, there was no significant increase of local or systemic tumors in studies relevant for medical devices. Taken together, the relevant in vivo data led to the conclusion that CoCA in medical devices are not a carcinogenic hazard in available in vivo models. While specific patient and implant factors cannot be fully replicated using in vivo models, the available in vivo preclinical data support that CoCA in medical devices are unlikely a carcinogenic hazard to patients.
The Leiden Thrombophilia Study (LETS) (1997)

Study Design (5) LETS was designed to assess the importance at the population level of various risk factors for thrombosis, many of which had been identified by family studies. Generally, two approaches are possible: cohort studies and case-control studies. In the former, patients with and without a risk factor are followed over time, and absolute risks (probability of disease, incidence) and relative risks (incidence rate ratio) can be calculated. In a case-control study, patients with thrombosis and healthy controls are included, and relative risks (odds ratios) can be calculated. Due to the rarity of the genetic risk factors for thrombosis, a follow-up study of a truly unselected sample from the
Response: Hypertension and Low-Level Lead Exposure in African Americans: A Public Health Reality (2003)

HomeHypertensionVol. 0, No. 1Response: Hypertension and Low-Level Lead Exposure in African Americans: A Public Health Reality Free AccessOtherPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessOtherPDF/EPUBResponse: Hypertension and Low-Level Lead Exposure in African Americans: A Public Health Reality Suma Vupputuri, Vecihi Batuman and Jiang He Suma VupputuriSuma Vupputuri , Vecihi BatumanVecihi Batuman and Jiang HeJiang He Originally published28 Jul 2003https://doi.org/10.1161/01.HYP.0000085860.09080.E2Hypertension. 2003;0Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: August 1, 2018: Ahead of Print "Response: Hypertension and Low-Level Lead Exposure in African Americans: A Public Health Reality." Hypertension, , pp. – Previous Back to top Next FiguresReferencesRelatedDetails January 2019Vol 0, Issue 1 Advertisement Article InformationMetrics https://doi.org/10.1161/01.HYP.0000085860.09080.E2 Originally publishedJuly 28, 2003 PDF download Advertisement
Lensing Probabilities for Spectroscopically Selected Galaxy‐Galaxy Strong Lenses (2008)

Spectroscopic galaxy-galaxy lens searches are presently the most prolific method of identifying strong lens systems in large data sets. We study the probabilities associated with these lens searches, namely the probability of identifying a candidate with rogue [OII] emission lines in a galaxy's spectrum, and the probability that the candidate will show features of strong lensing in follow-up photometric observations. We include selection effects unique to spectroscopic data, and apply them to the Sloan Lens ACS (SLACS) survey (Bolton et al. 2006). The most significant selection effect is the finite size of the spectroscopic fiber which selects against large separation lenses and results in a non-monotonic dependence of the rogue line probability on velocity dispersion. For example, with the 3 arcsec diameter SDSS fiber and 2 arcsec FWHM seeing, we find that the probability that a given LRG has a rogue [OII] line in its spectrum decreases with velocity dispersion from 150 km/s to 300 km/s and then increases up to 400 km/s for a given source size. The total probability for observing a rogue line in a single survey spectrum is ~0.9-3.0%, and the total lensing rate is ~0.5-1.3%. The range is due to uncertainties in the physical size of [OII] emission regions, and in the evolution of the [OII] luminosity function. Our estimates are a factor of ~5 higher than the results of the SLACS survey, a discrepancy which we attribute to the SLACS requirement that multiple rogue lines be observed simultaneously.
Phase-error-free quadrature sampling technique in the ultrasonic B-scan imaging system and its application to the synthetic focusing system (1993)

The quadrature sampling technique as a means of detecting the envelope of RF waveform in the baseband is well known. If this technique is applied to a focused ultrasound imaging system using an array transducer, whether it is a synthetic or nonsynthetic focusing system, unwanted phase terms appear in the expressions of the inphase and quadrature components of the baseband signal when an appropriate delay time is introduced to each channel signal for the purpose of focusing. The expressions of the inphase and quadrature components from the point of focusing are derived and analyzed in detail, and a scheme to eliminate the unwanted phase terms is proposed. The resulting phase-error-free quadrature sampling technique is applied to the synthetic focusing system; a system block diagram together with the simulation and experimental results are presented.
Advances in the characterization of pore geometry and pore fluids by nuclear magnetic resonance (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Advances in the characterization of pore geometry and pore fluids by nuclear magnetic resonanceAuthors: Martin D. HürlimannMartin D. HürlimannSchlumberger‐Doll Research, Ridgefield, CT 06877‐4108https://doi.org/10.1190/1.1885822 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885822FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Martin D. Hürlimann, (1997), "Advances in the characterization of pore geometry and pore fluids by nuclear magnetic resonance," SEG Technical Program Expanded Abstracts : 1934-1937. https://doi.org/10.1190/1.1885822 Plain-Language Summary PDF DownloadLoading ...
Metal-Semiconductor Field-Effect Transistor Made Using Amorphous In-Ga-Zn-O Channel and Bottom Pt Schottky Contact Structure at 200 C (2012)

Amorphous In-Ga-Zn-O (a-IGZO) based metal-semiconductor field-effect transistors (MESFETs) were fabricated at 200°C. A bottom Pt structure was employed to form a good Schottky gate, and channel thickness was optimized to 230 nm to obtain high on-currents Ion > 10−6 A, on-to-off current ratios > 106 and low subthreshold voltage swing of 129 mV/decade. The field-effect mobility (μFE) was as small as 0.5 cm2(Vs)−1, which is explained quantitatively by the subgap trap density in the 200°C-annealed a-IGZO. The present result suggests that a double-layered channel with different donor densities will be effective to improve Ion and μFE of a-IGZO MESFETs.
Optimal radome design with particle swarm optimization (2008)

In this paper, we presented the optimal radome design using optimization algorithm. The radome performance is optimized by adjusting the thickness of the radome layer and the shape of the radome. The numerical results and observations indicated that MPSO, which adopts a concept of “mutation” in GA, is capable of performing better and more stably than the conventional PSO and GA with respect to searching the global optima without any burden such as tuning the parameters of the algorithms in an actual design procedure. We also confirmed that the transmission coefficients attained by the optimal radome synthesis is well above −2dB for the entire frequency bandwidth evaluated.
Production of Spliced DNA Copies of the Cottontail Rabbit Papillomavirus Genome in a Retroviral Vector (2007)

The early region of the cottontail rabbit papillomavirus (CRPV) genome has been introduced into a retroviral vector and recombinant retroviruses, produced upon transfection of the psi 2 packaging cell line, have been used to infect NIH 3T3 cells. Spliced derivatives of the CRPV early region can be rescued from the infected cells. Sequence analysis demonstrates that the major splicing event observed in RNA in tumours is faithfully reproduced in this system. This splice generates a polycistronic mRNA that contains in its 5' portion the E7 open reading frame, or both E6 and E7, and at its 3' end a reading frame with codons for three amino acids from the N-terminus of E1 linked to codons for 100 amino acids from the C-terminus of the E4 region. Recombinant retroviruses containing intact or spliced CRPV sequences can now be used to introduce the viral genes efficiently into a variety of cell lines.
Preparation of (2-Methyl-propane-2-sulfonylimino) Acetic Acid Ethyl Ester (2004)

Synthesis of (2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester from tert-butylsulfonamide, thionyl chloride and ethyl glyoxylate is described. The N-tert-butylsulfonyl imino ester has served as a substitute of the corresponding N-toluenesulfonyl imino ester in allylation reactions.
Combustion Characteristic of Catalytic Plate Burner. (1999)

A plate burner with a stack of ceramic filaments, which are catalyzed with Pd are investigated by experiment. As the features of this burner a flame is held near the burner surface because its complicated passages of premixed gas cause vortices to be produced, and also the plate is cooled well by the low temperature premixed gas due to the large passage surface area. The flame made by gas phase reaction activates the catalyst, so that catalytic reaction is caused on the plate surface. Therefore, a preheating device to heat up the burner will not be needed. Two key issues have been examined in this study ; one is the relation between gas phase reaction and surface reaction, and the other is combustion characteristics of this burner. As a result, it is confirmed that the flame made by gas phase reaction causes surface phase reaction a few minutes after ignition. Furthermore, surface reaction activities by catalyst are reduced as either combustion load or excess air ratio increases. However, the concentrations of NOx and CO can be reduced in a high activity region of catalyst.
Characterisation of gene delivery using liposomal bubbles and ultrasound (2011)

The combination of nano/microbubbles and ultrasound is a novel technique for a non‐viral gene deliver. We have previously developed novel ultrasound sensitive liposomes (Bubble liposomes) which contain the ultrasound imaging gas perfluoropropane. In this study, Bubble liposomes were compared with cationic lipid (CL)–DNA complexes as potential gene delivery carriers into tumors in vivo. The delivery of genes by bubble liposomes depended on the intensity of the applied ultrasound. The transfection efficiency plateaued at 0.7 W/cm2 ultrasound intensity. Bubble liposomes efficiently transferred genes into cultured cells even when the cells were exposed to ultrasound for only 1 s. In addition, bubble liposomes were able to introduce the luciferase gene more effectively than CL‐DNA complexes into mouse ascites tumor cells. We conclude that the combination of Bubble liposomes and ultrasound is a good method for gene transfer in vivo.
Log-likelihood detection ordering for MMSE-SIC in V-BLAST systems (2006)

In the conventional successive interference canceling (SIC) detection algorithm of V-BLAST, the detection ordering does not exploit the instantaneous effect of the noise. In some previous studies, based on zero-forcing SIC (ZF-SIC) scheme, it has been presented that the detection ordering by the magnitude of log-likelihood ratio (LLR) significantly outperforms the conventional detection ordering by signal to noise ratio (SNR) for V-BLAST. In this paper, an extension of LLR-based ordering to the minimum mean square error (MMSE) detector is proposed. We have derived an accurate formula for LLR with respect to MMSE detector. We also propose an approximate formula for LLR, which can decrease the computational complexity in a large extent. The high improvement of system performance is demonstrated via simulation results. Besides, some extensions to M-ary signaling have also been proposed.