gebhart/patrepeval huggingface dataset:
Accurate prediction of acute fish toxicity of fragrance chemicals with the RTgill-W1 cell assay (2017)

Testing for acute fish toxicity is an integral part of the environmental safety assessment of chemicals. A true replacement of primary fish tissue was recently proposed using cell viability in a fish gill cell line (RTgill-W1) as a means of predicting acute toxicity, showing good predictivity on 35 chemicals. To promote regulatory acceptance, the predictivity and applicability domain of novel tests need to be carefully evaluated on chemicals with existing high-quality in vivo data. We applied the RTgill-W1 cell assay to 38 fragrance chemicals with a wide range of both physicochemical properties and median lethal concentration (LC50) values and representing a diverse range of chemistries. A strong correlation (R<sup>2</sup> = 0.90-0.94) between the logarithmic in vivo LC50 values, based on fish mortality, and the logarithmic in vitro median effect concentration (EC50) values based on cell viability was observed. A leave-one-out analysis illustrates a median under-/overprediction from in vitro EC50 values to in vivo LC50 values by a factor of 1.5. This assay offers a simple, accurate, and reliable alternative to in vivo acute fish toxicity testing for chemicals, presumably acting mainly by a narcotic mode of action. Furthermore, the present study provides validation of the predictivity of the RTgill-W1 assay on a completely independent set of chemicals that had not been previously tested and indicates that fragrance chemicals are clearly within the applicability domain. Environ Toxicol Chem 2018;37:931-941. © 2017 SETAC.
Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model (2012)

Sustained and controlled delivery of growth factors, such as bone morphogenetic protein 2 (BMP-2), from polymer scaffolds has excellent potential for enhancing bone regeneration. The present study investigated the use of novel sintered polymer scaffolds prepared using temperature-sensitive PLGA/PEG particles. Growth factors can be incorporated into these scaffolds by mixing the reconstituted growth factor with the particles prior to sintering. The ability of the PLGA/PEG scaffolds to deliver BMP-2 in a controlled and sustained manner was assessed and the osteogenic potential of these scaffolds was determined in a mouse calvarial defect model. BMP-2 was released from the scaffolds in vitro over 3 weeks. On average, ca. 70% of the BMP-2 loaded into the scaffolds was released by the end of this time period. The released BMP-2 was shown to be active and to induce osteogenesis when used in a cell culture assay. A substantial increase in new bone volume of 55% was observed in a mouse calvarial defect model for BMP-2-loaded PLGA/PEG scaffolds compared to empty defect controls. An increase in new bone volume of 31% was observed for PLGA/PEG scaffolds without BMP-2, compared to empty defect controls. These results demonstrate the potential of novel PLGA/PEG scaffolds for sustained BMP-2 delivery for bone-regeneration applications.
<title>Image processing for magnetic-resonance elastography</title> (1996)

A newly developed magnetic resonance imaging technique can directly visualize propagating acoustic strain waves in tissue-like materials. By estimating the local wavelength of the acoustic wave pattern, quantitative values of shear modulus can be calculated and images generated that depict tissue elasticity or stiffness. Since tumors are significantly stiffer than normal tissue (the basis of their detection by palpation), this technique may have potential for 'palpation by imaging,' with possible application to the detection of tumors in breast, liver, kidney, and prostate. We describe the local wavelength estimation algorithm, study its properties, and show a variety of sample results.
Peritoneal dialysis for acute kidney injury: Equations for dosing in pandemics, disasters, and beyond (2020)

The equations are intended as a practical tool to estimate solute clearances and guide prescription of continuous PD. The estimated dialysate volume required for any dose target can be calculated from cycle duration or dwell volume. However, the exact target dose of PD is uncertain and should be adjusted according to the clinical circumstances and response to treatment. The equations presented in this article facilitate the adjustment of PD prescription toward the targeted solute clearance.
Nanohardness of abrasive particles used in magnetorheological finishing (MRF) (2000)

The nanohardness of individual micron-sized magnetic and nonmagnetic abrasives used in magnetorheological finishing (MRF) has been successfully measured using novel nanoindentation techniques. Results are validated by comparison with existing microhardness data found in the literature.
Establishment of Stable hFis1 Knockdown Cells with an siRNA Expression Vector (2004)

Yeast Fis1p participates in mitochondrial fission, together with Dnm1p and Mdv1p. Recently, human Fis1 (hFis1) was reported to be involved in mitochondrial fission, together with Drp1. We established stable transformants with an hFis1 siRNA expression vector. In the stable hFis1 knockdown cells, hFis1 expression was suppressed to approximately 10%, and mitochondrial fission, induced by cisplatin treatment, was delayed. In addition, mouse Fis1 (mFis1) expression promoted mitochondrial fission and cell death in the hFis1 knockdown cells, suggesting that mFis1 complements the function of hFis1. These hFis1 siRNA expression vectors may be useful for studying the molecular function of mammalian Fis1.
A prospective randomized trial of single- or dual-chamber implantable cardioverter-defibrillators to minimize inappropriate shock risk in primary sudden cardiac death prevention (2014)

clinicaltrials.gov Identifier: NCT00787800.
Multi-stage Carrier Phase Recovery and Nonlinear Polarization Crosstalk Canceller for XPM Mitigation (2011)

Novel XPM mitigation technique by coordination of carrier phase recovery and nonlinear polarization crosstalk canceller is proposed. It doubles the Q improvement over conventional method in 112Gb/s DP-QPSK transmission over 1500km SMF link.
Improvement of Interfacial Adhesion of Biodegradable Polymers Coated on Metal Surface by Nanocoupling (2011)

A method of securing the adhesion of biodegradable polymer coating was investigated for drug-eluting metal stents, using surface-initiated ring-opening polymerization (SI-ROP) of L-lactide. Introduction of oligolactide on the stainless steel (SS) surface was successful and the thickness of the oligolactide grafts remained on the nanometer scale, as determined by ellipsometry. The presence of an oligolactide graft was also identified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA). On top of the grafts, poly(D,L-lactide-co-glycolide) (PLGA) coating was carried out on different substrates such as SS control, plasma-treated SS, and lactide-grafted (referred to as a nanocoupled) SS using electrospraying. When the adhesion forces were measured with a scratch tester, the nanocoupled SS showed the strongest interfacial adhesion between polymer coating layer and metal substrate. The outcome of the peel-off test was also consistent with the result of the scratch test. When degradation behavior of the polymer coating in vitro was examined for up to 4 weeks in a continuous fluid flow, the SEM images demonstrated that polymer degradation was obvious due to hydration and swelling of the polymer matrix. Although the matrix completely disappeared after 4 weeks for SS control and plasma-treated substrates, the nanocoupled SS was persistent with some polymer matrix. In addition, the release profiles of SRL-loaded PLGA coating appeared slightly different between control and nanocoupled groups. This work suggested that the concept of nanocoupling remarkably improved the interfacial adhesion stability between metal surface and polymer layer and controlled drug release, and showed the feasibility of drug-eluting stents.
QUASI-NEWTON MULTIMODULUSBLIND EQUALIZATION ALGORITHM (2009)

In this work, a new stochastic Newton-like algorithmfor blind equalization is developed. This is obtained by applying a com­ plex Taylor series on a recently proposed soft constraint satisf ac­ tion multi-modulu s blind equalization algorithmoforder p (SCS­ MMA-p). The proposed algorithm is a generalized versionofthe SCS-MMA-pandis named as stochastic Newton-like soft constraint satisf action multi-modulusalgorithm oforder p (SNL-SCS-MMA­ p). Great improvement inperformanceofthe proposed algorithm is obtained against thatofthe SCS-MMAfordifferent values ofp. Index Terms - Blind equalization, Newton method, SNL­ SCS-MMA-p. To solve the problem of slow convergence in the CMA algo­ rithm , Gooch and lundell [8] applied the self-orthogonalizing con­ cept to blind equalization which resulted in fast convergence . This was originally applied on CMA and was named asOrthogonalized­ CMA (O-CMA) . In this work, we propose a Newton-like algorithm by employ­ ing complex Taylor series [9] on a recently proposed cost function [10]. In [11], the same technique has been applied on the cost function proposed in [6]. However, as it will be shown later, the work in [II] is a special case of our proposed work.
Data from HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin α<sub>v</sub>β<sub>6</sub> (2023)

&lt;div&gt;Abstract&lt;p&gt;Enhanced expression levels of integrin α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; have been linked to more aggressive invasive carcinoma cell behavior and poorer clinical prognosis. However, how α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; determines invasion and the dynamics of integrin α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; regulation in tumor cells are poorly understood. We have identified the 35-kDa HS1-associated protein X-1 (HAX-1) protein as a novel binding partner of the β&lt;sub&gt;6&lt;/sub&gt; cytoplasmic tail using a yeast two-hybrid screen. We show that α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt;-dependent migration is blocked following small interfering RNA (siRNA)–mediated depletion of HAX-1 in oral squamous cell carcinoma cell lines. Using both siRNA and membrane-permeable peptides, we show that α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt;-dependent migration and invasion require HAX-1 to bind directly to β&lt;sub&gt;6&lt;/sub&gt; and thereby regulate clathrin-mediated endocytosis of α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; integrins. Progression of oral cancer is associated with enhanced expression of α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt; and HAX-1 proteins in patient tissue. This report establishes that integrin endocytosis is required for α&lt;sub&gt;v&lt;/sub&gt;β&lt;sub&gt;6&lt;/sub&gt;-dependent carcinoma cell motility and invasion and suggests that this process is an important mechanism in cancer progression. [Cancer Res 2007;67(11):5275–84]&lt;/p&gt;&lt;/div&gt;
Conformation perturbation of p-sulfonatocalix[5]arene via complexation of 1,4-diazabicyclo[2.2.2]octane (2004)

A novel conformation of p-sulfonatocalix[5]arene has been established in the solid state with two calixarenes organised in a 'bis-molecular capsule' shrouding two di-protonated DABCO molecules and two water molecules within.
Laparoscopic Nephrectomy (2010)

SAGE-Journals-Accessible-Video-Player 10.1089/vid.2009.0025.M1 sj-vid-1-vid-10.1089_vid.2009.0025
Autonomy and interdependence in human-agent-robot teams (2012)

There is a common belief that making systems more autonomous will improve the system and is therefore a desirable goal. Though small scale simple tasks can often benefit from automation, this does not necessarily generalize to more complex joint activity. When designing today's more sophisticated systems to work closely with humans, it is important not only to consider the machine's ability to work independently through autonomy, but also its ability to support interdependence with those involved in the joint activity. We posit that to truly improve systems and have them reach their full potential, designing systems that support interdependent activity between participants is the key. Our claim is that increasing autonomy, even in a simple and benign environment, does not always result in an improved system. We will show results from an experiment in which we demonstrate this phenomena and explain why increasing autonomy can sometimes negatively impact performance.
Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals. (1994)

Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and that functional events occurring after cross-linking of membrane-bound IgE on these cells are mediated by these receptors. Here we demonstrate that peripheral blood monocytes can bind monomeric IgE via the high affinity IgE receptor (Fc epsilon RI) and that Fc epsilon RI expression on these cells is upregulated in atopic persons. Further, we demonstrate that, upon monocyte adherence to substrate, bridging of monocyte Fc epsilon RI is followed by cell activation. We propose that direct interaction of multivalent allergen with Fc epsilon RI(+)-bound IgE on mononuclear phagocytes results in cell signaling via Fc epsilon RI and that the biological consequences of this event may critically influence the outcome of allergic reactions.
Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography (2009)

Double circular scanning using Doppler FD-OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.
Photonic Packaging: Transforming Silicon Photonic Integrated Circuits into Photonic Devices (2016)

Dedicated multi-project wafer (MPW) runs for photonic integrated circuits (PICs) from Si foundries mean that researchers and small-to-medium enterprises (SMEs) can now afford to design and fabricate Si photonic chips. While these bare Si-PICs are adequate for testing new device and circuit designs on a probe-station, they cannot be developed into prototype devices, or tested outside of the laboratory, without first packaging them into a durable module. Photonic packaging of PICs is significantly more challenging, and currently orders of magnitude more expensive, than electronic packaging, because it calls for robust micron-level alignment of optical components, precise real-time temperature control, and often a high degree of vertical and horizontal electrical integration. Photonic packaging is perhaps the most significant bottleneck in the development of commercially relevant integrated photonic devices. This article describes how the key optical, electrical, and thermal requirements of Si-PIC packaging can be met, and what further progress is needed before industrial scale-up can be achieved.
Investigation of parameter tolerance on digitally controlled DC-DC converter with pole-zero-cancellation technique (2010)

This paper proposes an interesting control technique which cancels the transfer function of the converter by using pole-zero-cancellation method. The system stabilization design is easy to be realized by applying this technique. The impaired system stability caused by parameter variation is investigated, especially the influence of the output capacitance variation. Moreover, a parameter tracking method is included to solve the stability problem.
Synergistic Electrocatalytic Syngas Production from Carbon Dioxide by Bi‐Metallic Atomically Dispersed Catalysts (2022)

Abstract The production of syngas by traditional processes such as steam methane reforming is energetically intensive and produces a large amount of CO 2 emissions. In contrast, the electrochemical CO 2 reduction reaction (CO 2 RR) enables the carbon neutral production of syngas at ambient conditions. Among non‐precious metal catalysts, metal‐nitrogen‐carbon electrocatalysts are inexpensive and highly selective towards syngas production. This study examined the selectivity of mono‐ and bi‐metallic (M−N−C, M=Fe, Mo or FeMo) electrocatalysts towards syngas production. The ratio of the CO : H 2 in the syngas was tuned by modifying the ratio of the metallic precursors in the bi‐metallic FeMo−N−C catalysts, tailoring the catalysts’ selectivity towards the CO 2 RR or the hydrogen evolution reaction (HER). The catalyst synthesis temperature(s) were considered as they influence the catalyst morphology and activity. Further, the dependence of the ratio of CO : H 2 in the syngas as a function of the potential was explored for the different bi‐metallic catalysts. This work showed that by tailoring both the ratio of Fe : Mo in the bi‐metallic catalyst and optimizing the reductive potential, a CO : H 2 ratio between 0.25 to 5 was achievable. This study demonstrated a novel approach in which the ratio of the product syngas composition could be tailored in a single reaction, without the need for further downstream processing to reach a desired composition.
Chain Growth Polymerizations in Liquid and Supercritical Carbon Dioxide (1999)

The use of carbon dioxide as an alternative to traditional solvents has emerged recently as an important development in polymer chemistry. The past year has witnessed major advances in the synthesis of a variety of polymeric materials in carbon dioxide, with primary emphasis on utilizing carbon dioxide as an inert reaction medium. The scope of the studies conducted in our laboratories on chain-growth polymerizations covers free radical, cationic, and transition-metal-catalyzed polymerizations in liquid and supercritical carbon dioxide. These systems have included homogeneous and heterogeneous (including precipitation and dispersion) polymerizations, as well as hybrid carbon dioxide/aqueous phases. As will be shown, an array of polymers can be readily prepared using these polymerization methods in the environmentally friendly medium of liquid and supercritical carbon dioxide.
23.3: Surface Fluorination of MgO Protective Film to Reduce Chemical Reactivity with H 2 O and CO 2 (2003)

Abstract Just after fabrication of a MgO protective film by EB deposition, a surface modification of the film with a fluorinating gas was performed. This technique achieved a remarkable reduction in the amount of outgassing from the film, and therefore it can be expected to shorten the duration of the gas‐evacuation process in PDP manufacturing.
A putative plant organelle RNA recognition protein gene is essential for maize kernel development (2014)

Basal endosperm transfer layer (BETL) cells are responsible for transferring apoplastic solutes from the maternal pedicel into the endosperm, supplying the grain with compounds required for embryo development and storage reserve accumulation. Here, we analyze the maize (Zea mays L.) empty pericarp6 (emp6) mutant, which causes early arrest in grain development. The Emp6+gene function is required independently in both the embryo and endosperm. The emp6 mutant causes a notable effect on the differentiation of BETL cells; the extensive cell wall ingrowths that distinguish BETL cells are diminished and BETL marker gene expression is compromised in mutant kernels. Transposon tagging identified the emp6 locus as encoding a putative plant organelle RNA recognition (PORR) protein, 1 of 15 PORR family members in maize. The emp6 transcript is widely detected in plant tissues with highest levels in embryos and developing kernels. EMP6-green fluorescent protein (GFP) fusion proteins transiently expressed in Nicotiana benthamiana leaves were targeted specifically to mitochondria. These results suggest that BETL cell differentiation might be particularly energy intensive, or alternatively, that mitochondria might confer a developmental function.
Noise and Aliasing Aspects in a Multiharmonic-Dielectric-Response-Measurement System (2011)

Dielectric-response measurements are commonly performed with frequency-domain spectroscopy, polarization/depolarization-current measurements, or return-voltage measurements. These techniques operate in a frequency or time domain, and all have high requirements on the voltage source in order to acquire accurate results. This limits dielectric-response measurements to offline applications. A new technique, which is called arbitrary-waveform-impedance spectroscopy, has been developed, which makes use of the harmonics of any voltage waveform to perform dielectric-response measurements. The technique provides possibilities for online measurements facilitating the monitoring of materials and components in high-voltage applications. Here, the different aspects of the measurement system are presented, including circuit modeling, normalization, and discussions on aliasing and noise; all of them are necessary to control in order to perform accurate measurements.
Effect of auxiliary on hysteresis property of ferroelectric film by aerosol deposition (2008)

Concerning the ferroelectric films produced by AD method, the effects by adding auxiliary agents to injection powder and the effects by grain size were investigated for the purpose of realizing higher ferroelectric property. Ferroelectricity of AD film was found to be improved by adding low melting point auxiliary agents and using calcined powder, and was also found to depend on the grain size of injection powder, and to be improved by increasing the size to an appropriate value. By optimizing the conditions, good ferroelectricity was realized; such as Pr = 25.4 J.tC/cm 2 in the heat treatment at 600C (63% of sintered film, calcined powder added with low melting point glass) and Pr = 38.0 J.iCicm 2 in the heat treatment at 700C (95% of sintered film, calcined powder added with Bi 2 0 3 -Zn0).
Vaginal Lubrication After Cervicovaginal Stimulation is Facilitated by Phosphodiesterase Type 5 Inhibition in Ovariectomized Mice (2013)

Irrespective of the hormonal status, sildenafil increased vaginal lubrication. The vaginal effect of sildenafil was independent of the nNOS pathway and more pronounced in ovariectomized animals.
TimeML-compliant text analysis for temporal reasoning (2005)

Reasoning with time 1 needs more than just a list of temporal expressions. TimeML—an emerging standard for temporal annotation as a language capturing properties and relationships among timedenoting expressions and events in text—is a good starting point for bridging the gap between temporal analysis of documents and reasoning with the information derived from them. Hard as TimeMLcompliant analysis is, the small size of the only currently available annotated corpus makes it even harder. We address this problem with a hybrid TimeML annotator, which uses cascaded finite-state grammars (for temporal expression analysis, shallow syntactic parsing, and feature generation) together with a machine learning component capable of effectively using large amounts of unannotated data. 1 Temporal Analysis of Documents Many information extraction tasks limit analysis of time to identifying a narrow class of time expressions, which literally specify a temporal point or an interval. For instance, a recent (2004) ACE task is that of temporal expression recognition and normalisation (TERN; see