gebhart/patrepeval huggingface dataset:
Effects of the near-field on shallow seismic studies (2011)

Abstract Seismic studies in the near surface typically involve path lengths that are on the order of a wavelength. However, most investigators extrapolate seismic imaging and parameter extraction techniques to the near surface without incorporating the near-field in their processing approach. For such short path lengths, we find that the near-field is strongly present in the recorded waveforms, which consequently biases seismic parameter estimation, such as Q measurement. To suppress the near-field effects, we examined the challenges of near-field removal and the issues involving the accurate modeling of the near-field. Using the mathematical expression for a source monopole, which describes an elastic impact source typically used in shallow seismic studies, we modeled the near- and far-field terms of the waveform with distance in a homogeneous elastic medium. For thiscase, we found that the near-field can be suppressed through frequen-cy-domain or polarization filtering. However, in heterogeneous media, the near-field cannot be removed through filtering due to interference of scattered P- and S-converted waves. Hence, in realistic media it is necessary to compensate for the near-field bias in Q measurement via appropriate numerical modeling in 3D. To assess the near-field bias in real data, a vertical seismic profiling study was conducted at a site in the Lawrence Livermore National Laboratory, and it was found that the apparent attenuation due to the near-field is of order comparable to the combined effects of scattering and intrinsic attenuation. These results raise caution for the interpretation of extracted Q values in the near surface if they do not account for the near-field presence and point to the necessity of incorporating a near-field term in standard seismic processing techniques when applied to the near surface.
Outpatient Randomized Crossover Automated Insulin Delivery Versus Conventional Therapy with Induced Stress Challenges (2022)

<b><i>Background:</i></b> Automated insulin delivery (AID) systems have not been evaluated in the context of psychological and pharmacological stress in type 1 diabetes. Our objective was to determine glycemic control and insulin use with Zone Model Predictive Control (zone-MPC) AID system enhanced for states of persistent hyperglycemia versus sensor-augmented pump (SAP) during outpatient use, including in-clinic induced stress. <b><i>Materials and Methods:</i></b> Randomized, crossover, 2-week trial of zone-MPC AID versus SAP in 14 adults with type 1 diabetes. In each arm, each participant was studied in-clinic with psychological stress induction (Trier Social Stress Test [TSST] and Socially Evaluated Cold Pressor Test [SECPT]), followed by pharmacological stress induction with oral hydrocortisone (total four sessions per participant). The main outcomes were 2-week continuous glucose monitor percent time in range (TIR) 70-180 mg/dL, and glucose and insulin outcomes during and overnight following stress induction. <b><i>Results:</i></b> During psychological stress, AID decreased glycemic variability percentage by 13.4% (<i>P</i> = 0.009). During pharmacological stress, including the following overnight, there were no differences in glucose outcomes and total insulin between AID and physician-assisted SAP. However, with AID total user-requested insulin was lower by 6.9 U (<i>P</i> = 0.01) for pharmacological stress. Stress induction was validated by changes in heart rate and salivary cortisol levels. During the 2-week AID use, TIR was 74.4% (vs. SAP 63.1%, <i>P</i> = 0.001) and overnight TIR was 78.3% (vs. SAP 63.1%, <i>P</i> = 0.004). There were no adverse events. <b><i>Conclusions:</i></b> Zone-MPC AID can reduce glycemic variability and the need for user-requested insulin during pharmacological stress and can improve overall glycemic outcomes. Clinical Trial Identifier NCT04142229.
Quantum photonics for secure quantum and classical computing (Conference Presentation) (2019)

The precise quantum control of single photons, together with the intrinsic advantage of being mobile make optical quantum system ideally suited for delegated quantum information tasks, reaching from well-established quantum cryptography to quantum clouds and quantum computer networks. Here I will present that the exploit of quantum photonics allows for a variety of quantum-enhanced data security for quantum and classical computers. First, I will present a homomorphic-encrypted quantum random walk using single-photon states and non-birefringent integrated optics. The client encrypts their input state in the photons’ polarization degree of freedom, while the server performs the computation using the path degree of freedom. Then I will briefly discuss the realization of a feasible hybrid classical-quantum technology, which shows promising new applications of readily available quantum photonics technology for secure classical computing by enabling probabilistic one-time programs.
An evaluation of preference clustering in large-scale multicast applications (2002)

The efficiency of using multicast in multi-party applications is constrained by preference heterogeneity, where receivers range in their preferences for application data. We examine an approach in which approximately similar sources and receivers are clustered into multicast groups. The goal is to maximize preference overlap within each group while satisfying the constraint of limited network resources. This allows an application to control the number of multicast groups it uses and thus the number of connections it maintains. We present a clustering framework with a two-phase algorithm: a bootstrapping phase that groups new sources and receivers together, and an adaptation phase that re-groups them in reaction to changes. The framework is generic in that an application can customize the algorithm according to its requirements and data characteristics. We conducted detail simulation experiments to study various issues and tradeoffs in applying clustering to different preference patterns and application classes. We found that clustering successfully exploits preference similarity and utilizes network resources more efficiently than when it is not used. Also, application-level hints can be incorporated in our algorithm, which are instrumental in the creation of an effective grouping of sources and receivers. Our algorithm handles changes dynamically, and also limits multicast "join" and "leave" disruption to the application.
Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity (2008)

We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cell-based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication.
Data from Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment (2023)

&lt;div&gt;Abstract&lt;p&gt;The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are “self,” therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor β (TGFβ) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGFβ will enhance vaccine efficacy. (Clin Cancer Res 2009;15(21):1–3) (Clin Cancer Res 2009;15(21):6476–8)&lt;/p&gt;&lt;/div&gt;
Designing Document Solutions for Airline Maintenance Advisories (2011)

At the turn of the 21st century, Xerox Global Services (XGS) was looking to build on Xerox's traditional strengths in product development and solutions sales by providing business process consulting and outsourcing services for large enterprise customers. This would expand the value Xerox could bring to its large customer base by helping customers reduce operating costs and improve processes. XGS was deploying conventional approaches such as Lean Six Sigma (LSS) as well as developing a set of assessment tools to help guide and define their consulting practices.
Evidence for Bidentate and Terdentate Coordination of the Ligand 2,2′:6′,2″-Terpyridine in Oxotechnetium(V) Complexes (1992)

Abstract Complexes formed by the ligand exchange reactions of [TcOCl4]− with the potentially terdentate nitrogen-donor ligand 2,2′:6′,2″-terpyridine (terpy) under different reaction conditions have been investigated. Both bidentate and terdentate coordination of terpy have been established in the complexes prepared. In dichloromethane as reaction medium the six-coordinate complex TcOCl3(terpy-N,N′) has been isolated, in which terpy acts as a bidentate ligand. The reaction of terpy with a twofold molar excess of [TcOCl4]− in boiling ethanol led to the formation of the cationic six-coordinate complex [TcOCI2(terpy-N,N′,N″)]+, which precipitated from solution as the pertechnetate salt. With terpy in excess to [TcOCI4]− the cationic dimeric complex μ-O[TcOCl(terpy-N,N′,N″)]2Cl2. was isolated in ethanol. The reaction of TcO− 4 with terpy in an ethanolic/HCl solution led to the precipitation of the neutral six-coordinate complex TcOCl3(terpy .HC1), which could also be prepared from [TcOCl4]−. These compounds were characterized by elemental analysis, vibrational, optical and proton nuclear magnetic resonance spectroscopy.
Characterization of perfluorocarbon nanodrops with 18-MHz plane waves (2018)

Perfluorocarbon (PF) nanodrops (NDs) undergo a phase change from liquid to vapor with an acoustic stimulation. Activation thresholds are established with relatively high-concentrations of NDs. Activating single NDs with high-frequency plane waves without the need to switch between transmit waveforms would allow uninterrupted high-speed imaging studies to be undertaken in microvasculature. Lipid-coated perfluoropentane (PFP) or perfluorohexane (PFH) NDs were made via sonication (S) or sonication and extrusion (SE). A control sample consisted of lipid blend (LB) without PF. A Verasonics Vantage with an 18-MHz array was used to acquire backscatter data from activated NDs. A test tank with a 200-μm diameter input flow channel was used to pass a diluted concentration of NDs into the image plane of the array. The injection flow rate was 55 mL/hr. Batches of 5 plane waves were transmitted over ± 5 degrees at an effective PRF of 1000 Hz. Data were collected over 10 s intervals and then processed to count activation events. An event was defined as a backscatter signal 25 dB above background noise. PFPSE showed the highest counts at a given pressure. Agents appeared to be activated prior to entering the image plane. PFPS cases showed a reduced rate of activation but with a similar linear rise. PFH and LB had minimal to no events. The data indicate a small fraction of the injected agents were activated but do not indicate a distinct activation threshold was reached.
High Temperature Unclamped Inductive Switching Mode Evaluation of SiC JFET (2013)

Silicon carbide (SiC) unipolar transistors are an efficient choice in the design of high temperature 1200 V switching power supplies and dc-dc converters. To reduce the form factor and increase the power density of the circuit, the switching frequency must be high. This intensifies the negative impact of parasitic inductance and results in high voltage spikes that can drive a switching device into breakdown, followed by rapid destruction. To study the device performance under unclamped inductive switching (UIS) conditions, a normally-ON 1200 V/13-A SiC junction field-effect transistor (JFET) is driven into punch through breakdown using a single pulse. The testing is performed using an UIS setup, in which energy initially stored in an inductor is discharged through the JFET. The testing comprises of 90 single pulses each at 25 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C and 100 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C case temperatures for different gate voltages and drain current values. The peak energy and power dissipated in the JFET are 621 mJ and 16 kW, respectively, at the rated 1200 V blocking voltage and 13-A drain current. The JFET triode breakdown characteristics are unchanged after 180 single-pulse switching events indicating the robust nature of the device under extreme breakdown conditions. In addition, the 621 mJ peak UIS energy and its corresponding 8871 mJ/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> density dissipated in the JFET are the highest reported for any SiC power device.
Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory (2008)

The use of copper surfaces within the clinical environment and application of a germination solution in infection control procedures may offer a novel way forward in eliminating C. difficile from contaminated surfaces and reducing CDAD.
Supplementary Table 1 from Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358 (2023)

Supplementary Table 1 from Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia (2008)

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine, 4 (A-987306) is a new histamine H(4) antagonist. The compound is potent in H(4) receptor binding assays (rat H(4), K(i) = 3.4 nM, human H(4) K(i) = 5.8 nM) and demonstrated potent functional antagonism in vitro at human, rat, and mouse H(4) receptors in cell-based FLIPR assays. Compound 4 also demonstrated H(4) antagonism in vivo in mice, blocking H(4)-agonist induced scratch responses, and showed anti-inflammatory activity in mice in a peritonitis model. Most interesting was the high potency and efficacy of this compound in blocking pain responses, where it showed an ED(50) of 42 mumol/kg (ip) in a rat post-carrageenan thermal hyperalgesia model of inflammatory pain.
Estimating the output power of flat pickups in complex IPT systems (2008)

Inductive power transfer (IPT) has been successfully applied to single phase track systems to transfer power to moving vehicles without contact. Such systems suffer from a rapid reduction in transferred power as the track and pickup become misaligned. This has hindered their use in vehicular systems where the pickups must be allowed to move freely. Poly-phase IPT tracks have recently been proposed as a method of increasing the tolerance of the system to horizontal misalignment of mobile pick-ups. The substantial improvement in the tolerance of the system to misalignment is complicated by the number of design variables in the system, making it difficult to produce an optimal design. This paper presents a method of obtaining a first order estimate of the output power from a standard flat pick-up when used in an IPT system with an arbitrary track. This is achieved by exploiting the linear nature of non-saturating magnetic circuits to combine the system response from one track conductor into a composite that accounts for all the conductors. The estimate can be used to quickly and easily optimize the design of an entire IPT system. The final solution can then be simulated, built and experimentally verified.
A priori wiring estimations and optimal multilevel wiring networks for portable ULSI systems (2002)

Based on Rent's rule, a well established empirical relationship, a rigorous derivation of a complete wire length distribution for on-chip random logic networks is performed and then used to describe an optimal architecture for a multilevel wiring network that provides maximum interconnect density and minimum power for a portable ULSI system.
"Metallurgical and superconducting properties of multifilamentary V&lt;inf&gt;3&lt;/inf&gt;Ga wires" (1983)

Multifilamentary V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga wires containing small additions of yttrium have been produced commercially for the Naval Research Laboratory by Airco Superconductors Inc. These conductors containing 55 and 3025 filaments were metallurgically processed through a combination of hot extrusion and wire drawing. The yttrium additions were found to soften the vanadium alloy and consequently enhance the size reductions necessary to produce the wire without detrimental effects to previously achieved growth rates and critical current properties.
A method for visual model learning during tracking (2010)

In this paper, we propose a new method for visual model learning. The algorithm learns an
 object representation by one-shot and adaptively extends a set of saliency filters. The filter coefficients
 are extracted from the environment by different views. In addition, the algorithm fuses already learned
 visual filters and derives new visual classifiers in order to gain generalized object concepts. We evaluate
 our method on tracked sequences that are resulted from a processing with a visual bottom-up attention
 model.
BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets (1993)

The human BCR-ABL oncogenes encoded by the Philadelphia chromosome (Ph) affect the pathogenesis of diverse types of leukemia and yet are rarely associated with T-lymphoid leukemia. To determine whether BCR-ABL kinases are inefficient in transforming T lymphocytes, BCR-ABL-expressing retroviruses were injected intrathymically into mice. Thymomas that expressed BCR-ABL kinase developed after a relatively long latent period. In most thymomas, deletion of 3' proviral sequences resulted in loss of tk-neo and occasionally caused expression of kinase-active carboxy-terminally truncated BCR-ABL oncoprotein. In contrast, deletion of 3' proviral sequences was not observed in thymomas induced with Abelson murine leukemia virus (A-MuLV). BCR-ABL viruses induced distinct patterns of disease and involved different thymocyte subsets than A-MuLV and Moloney murine leukemia virus (Mo-MuLV). While Mo-MuLV only induced Thy-1+ thymomas, v-abl- and BCR-ABL-induced thymomas often contained mixed populations of B220+ and Thy-1+ lymphocytes in the same tumor. In most v-abl and BCR-ABL tumors, Thy-1+ lymphoid cells expressed CD8 and a continuum of CD4 ranging from negative to positive. Conversely, Mo-MuLV thymomas contained distinct populations of CD4+ cells that were either CD8+ or CD8-. A-MuLV-transformed T-lymphoid cells did not express the CD3/T-cell receptor complex, while BCR-ABL tumors were CD3+. Thus, BCR-ABL viruses preferentially induce somewhat more differentiated T lymphocytes than are transformed by A-MuLV. Furthermore, rare B220+ lymphocytes may represent preferred v-abl and BCR-ABL transformation targets in the thymus.
Learning to Solve Voxel Building Embodied Tasks from Pixels and Natural Language Instructions (2022)

The adoption of pre-trained language models to generate action plans for embodied agents is a promising research strategy. However, execution of instructions in real or simulated environments requires verification of the feasibility of actions as well as their relevance to the completion of a goal. We propose a new method that combines a language model and reinforcement learning for the task of building objects in a Minecraft-like environment according to the natural language instructions. Our method first generates a set of consistently achievable sub-goals from the instructions and then completes associated sub-tasks with a pre-trained RL policy. The proposed method formed the RL baseline at the IGLU 2022 competition.
P4‐091: CIMA‐Q: QUEBEC's CONSORTIUM TO IDENTIFY PRODROMAL ALZHEIMER'S DISEASE (2014)

Quebec (Canada) is the second fastest aging society in the world. Concerted efforts are thus required to reduce the expected burden of Alzheimer's disease (AD). The Consortium pour l'identification précoce de la maladie d'Alzheimer - Quebec (CIMA-Q) is a newly created research structure supported by the Pfizer- Fonds de Recherche du Quebec - Santé innovation fund on AD. Investigators will develop and make available common methodological tools and platforms, which will vastly increase Quebec researchers' ability to contribute in a highly innovative fashion to acquisition of new knowledge in the field of AD. Specific objectives are to: 1) validate cognitive/clinical tests; 2) develop a standardized 'toolbox' combining biological, neuroimaging and cognitive markers; 3) identify novel AD-related molecular mechanisms; 4) identify disease progression-impacting lifestyle protective factors; and 5) implement clinical procedures allowing earlier and more accurate diagnosis of AD. All CIMA-Q data will be available to the research community. Four thematic groups (Cognitive/neuropsychiatric markers, Neuroimaging, Risk and protection factors, Therapeutic targets and biomarkers) will develop and use harmonized evaluation procedures for data collection. One hundred and fifty subjective memory impairment, 100 mild cognitive impairment, 50 AD dementia, 50 healthy older and 20 younger individuals will be recruited from five memory clinics and the NuAge cohort (a population-based cohort of 1,793 older adults). Participants will be characterized with clinical, cognitive and neuroimaging measures. Furthermore, a biobank of stem cell lines, cerebrospinal fluid, DNA/RNA, plasma/serum and progressively available autopsied brains will be established from these well-characterized subjects to identify pathological profiles, novel therapeutic targets and biomarkers. An established data management system (LORIS) will be used to store data and assist in subsequent queries and data analysis. Management policies and standardization/quality control procedures have been established. Operationalization of recruitment, data and biospecimen collection is currently under way. Subject recruitment is expected to start in the spring of 2014. The collaborative framework of CIMA-Q, federating more than 70 researchers from seven Quebec universities, will significantly increase high-impact pluridisciplinary research and productivity in the field of cognitive decline and AD. It will also increase opportunities for state of the art collaborative international research.