gebhart/patrepeval huggingface dataset:
Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity (2011)

UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferases (GalNAc-Ts) constitute a family of up to 20 transferases that initiate mucin-type O-glycosylation. The transferases are structurally composed of catalytic and lectin domains. Two modes have been identified for the selection of glycosylation sites by GalNAc-Ts: confined sequence recognition by the catalytic domain alone, and concerted recognition of acceptor sites and adjacent GalNAc-glycosylated sites by the catalytic and lectin domains, respectively. Thus far, only the catalytic domain has been shown to have peptide sequence specificity, whereas the primary function of the lectin domain is to increase affinity to previously glycosylated substrates. Whether the lectin domain also has peptide sequence selectivity has remained unclear. Using a glycopeptide array with a library of synthetic and recombinant glycopeptides based on sequences of mucins MUC1, MUC2, MUC4, MUC5AC, MUC6, and MUC7 as well as a random glycopeptide bead library, we examined the binding properties of four different lectin domains. The lectin domains of GalNAc-T1, -T2, -T3, and -T4 bound different subsets of small glycopeptides. These results indicate an additional level of complexity in the initiation step of O-glycosylation by GalNAc-Ts.
3. Ultra-Low-Noise CMOS Image Sensor with Reset-Gate-Less Pixel (2018)

CMOS CMOS (CIS: CMOS Image Sensor)
Scalable Wide and Deep Learning for Computer Assisted Coding (2018)

Marilisa Amoia, Frank Diehl, Jesus Gimenez, Joel Pinto, Raphael Schumann, Fabian Stemmer, Paul Vozila, Yi Zhang. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 3 (Industry Papers). 2018.
Coupled antenna scheme using filter design techniques and tunable resonators to show simultaneous transmit and receive (2013)

In order to enable multifunction arrays with simultaneous transmit and receive, high isolation must be provided between antenna elements. This isolation should ideally be independent of the waveforms being transmitted. In this paper, a tunable baffle design is presented which provides over 30 dB of improvement in isolation for bandwidths of 7.5 MHz between adjacent antennas. This isolation can be tuned in frequency to protect a given receive channel from transmitter interference. Filter approaches are used to analyze the antenna design and extract the interactions between each resonator. The antennas and the resonant baffles can be modeled as one coupling matrix just as in filter design approaches. This allows a notch filter to be created in which the direct coupling path between antenna patches is counteracted by the interaction of the resonators in the baffle.
Accelerating generalized linear models with MLWeaving: a one-size-fits-all system for any-precision learning (2019)

Learning from the data stored in a database is an important function increasingly available in relational engines.Methods using lower precision input data are of special interest given their overall higher efficiency.However, in databases, these methods have a hidden cost: the quantization of the real value into a smaller number is an expensive step.To address this issue, we present ML-Weaving, a data structure and hardware acceleration technique intended to speed up learning of generalized linear models over low precision data.MLWeaving provides a compact in-memory representation that enables the retrieval of data at any level of precision.MLWeaving also provides a highly efficient implementation of stochastic gradient descent on FPGAs and enables the dynamic tuning of precision, instead of using a fixed precision level during learning.Experimental results show that MLWeaving converges up to 16 faster than low-precision implementations of first-order methods on CPUs.
Multiuser MIMO Systems (2011)

This chapter contains sections titled: MIMO Fundamentals MIMO in LTE-Advanced and 802.16m Generic Linear Precoding with CSIT CSI Acquisition for Multiuser MIMO Future Directions of MIMO Techniques References
Grant funding: Playing the odds (2016)

Few science policy issues are more important than the allocation of research funding. Although a 2015 Report suggested that peer review has some ability to prioritize applications ([ 1 ][1]), it is not clear that the best science is being funded ([ 2 ][2]). There is evidence of poor precision and
A Novel RF Sensing Circuit Using Injection Locking and Frequency Demodulation for Cognitive Radio Applications (2009)

A novel RF sensing circuit for a cognitive radio to sense spectral environment is proposed using injection locking and frequency demodulation techniques. The research starts with deriving a generalized locking equation for oscillators as a theoretical basis, and then develops the sensing principle and circuit architecture to a practical and useful level. To accurately evaluate the sensing performance, a discrete time approach is investigated to compute the sensed output signal. In the experiments, a prototype circuit is designed in the 2.4-GHz industrial-scientific-medical band to cover a sensing frequency range from 2.4 to 2.484 GHz. The spectrum scanning over the 84-MHz bandwidth is accomplished in less than 1 ms. The experimental results agree quite well with the theoretical predictions, showing that the proposed RF sensing circuit can fast and reliably detect frequency and power for analog and digital modulation signals.
A Phase II Trial of Temozolomide and IFN- α in Patients with Advanced Renal Cell Carcinoma (2004)

The combination of temozolomide (TEM) and interferon-alpha (IFN-alpha) previously demonstrated a 30% response rate in metastatic melanoma. A single institution, phase II trial evaluating the efficacy of TEM/IFN in patients with advanced renal cell carcinoma (RCC) was conducted. Safety and tumor response were the main outcomes. Eligible patients received 200 mg/m(2)/day TEM orally on days 1-5 every 28 days, with IFN 2.5 million U/m(2)/day subcutaneously (s.c.) three alternate days/week for days 1-15 first cycle, then 5 million U/m(2)/day s.c. 3 alternate days/week throughout each 28-day cycle. Efficacy was evaluated every 8 weeks, and dose-limiting toxicities (DLTs) were treated with dose reductions of the culprit drug. Sixteen patients (ages 37-67) were initially enrolled. Of the 14 evaluable patients, there was one minor response. Best response was stable disease, with 7 patients remaining on study for > or =6 months. Five were alive for more than 2 years, and 2 remain alive at 45 and 50 months after enrollment. DLTs included TEM-induced myelosuppression and IFN-induced fever/chills. Other toxicities were mild to moderate (grades 1-3). The combination of TEM/IFN proved quite tolerable. This regimen appears inactive in terms of response in this population with poor prognosis, but the patients with stable disease > or =6 months remain of interest.
Ballistic transport and surface scattering in (In,Ga)As-InP heterostructure narrow channels (2023)

Abstract Narrow conduction channels are fabricated from an In 0.75 Ga 0.25 As-InP heterostructure using electron-beam lithography and dry etching. The etched surface is realized to be smooth by employing a reactive ion etching. The etching-induced surface conduction is eliminated by removing the damaged surface layer using a diluted HCl solution. The negligible surface depletion for the In-rich quantum well enables to create conducting channels in arbitrary geometries such as in a circular shape. We evidence the presence of a ballistic contribution in the electron transport by demonstrating a rectification of rf excitations that is achieved by the magnetic-field-tuned transmission asymmetry in the circularly-shaped channels. The absence of the surface depletion is shown to cause, on the other hand, a surface scattering for the electrons confined in the channels. An increase of the resistance, including its anomalous enhancement at low temperatures, is induced by the gas molecules attached to the sidewalls of the channels. We also report a large persistent photoconduction, which occurs as a parallel conduction in the undoped InP barrier layer.
Induction and Function of Lipocalin Prostaglandin D Synthase in Host Immunity (2007)

Although mainly expressed in neuronal cells, lipocalin-type PGD synthase (L-PGDS) is detected in the macrophages infiltrated to atherosclerotic plaques. However, the regulation and significance of L-PGDS expression in macrophages are unknown. Here, we found that treatment of macrophages with bacterial endotoxin (LPS) or Pseudomonas induced L-PGDS expression. Epigenetic suppression of L-PGDS expression in macrophages blunted a majority of PGD(2) produced after LPS treatment. Chromatin immunoprecipitation assays show that L-PGDS induction was regulated positively by AP-1, but negatively by p53. L-PGDS expression was detected in whole lung and alveolar macrophages treated with LPS or Pseudomonas. L-PGDS overexpressing transgenic mice improved clearance of Pseudomonas from the lung compared with nontransgenic mice. Similarly, intratracheal instillation of PGD(2) enhanced removal of Pseudomonas from the lung in mice. In contrast, L-PGDS knockout mice were impaired in their ability to remove Pseudomonas from the lung. Together, our results identify induction of L-PGDS expression by inflammatory stimuli or bacterial infection, the regulatory mechanism of L-PGDS induction, and the protective role of L-PGDS expression in host immune response. Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia.
Tumor Budding and Recurrence in Submucosal Invasive Colorectal Cancers of Favorable Histology: Case Reports of Two Early Colorectal Cancers with Advanced Recurrences (2012)

Complete resection of submucosal invasive colorectal cancer (SICC) showing favorable histology is regarded as curative. We report on two cases of SICC showing recurrence within 5 years despite complete resection. The first patient was a 68-year-old woman with well differentiated rectal adenocarcinoma invading the superficial submucosa, which recurred after 4.7 years. The second patient was a 53-year-old man with pT1N0 moderately differentiated colonic adenocarcinoma. He developed widespread tumor recurrence after 3.9 years. Retrospective pathologic review of the original tumors showed multiple foci of tumor budding at the invasive front. Immunohistochemical staining for D2-40 of deeper levels of the paraffin blocks showed rare foci of small lymphatic invasion. Tumor budding at the invasive front may be an important indicator for SICC aggressiveness or may reflect early lymphatic invasion. More aggressive pathologic examination and follow-up is required for patients with SICC showing tumor budding, even in the absence of unfavorable histologic findings.
Chemistry, spectroscopy, and isotope-selective infrared photochemistry of a volatile uranium compound tailored for 10-.mu. absorption: uranium hexamethoxide (U(OCH3)6) (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry, spectroscopy, and isotope-selective infrared photochemistry of a volatile uranium compound tailored for 10-.mu. absorption: uranium hexamethoxide (U(OCH3)6)Edward A. Cuellar, Steven S. Miller, Tobin J. Marks, and Eric WeitzCite this: J. Am. Chem. Soc. 1983, 105, 14, 4580–4589Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00352a013https://doi.org/10.1021/ja00352a013research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small-Angle Neutron and X-ray Scattering from Amphiphilic Stimuli-Responsive Diamond-Type Bicontinuous Cubic Phase (2007)

The structural evolution of a diamond-type bicontinuous lipid cubic phase upon application of thermal and chemical (hydration agent) stimuli is investigated by means of small-angle neutron (SANS) and X-ray scattering (SAXS). The soft-matter cubic architecture responds by dramatic swelling (DLarge cubic structure) upon incorporation of a hydration-enhancing guest component (octyl glucoside) at low and ambient temperatures, the aqueous channel diameter increasing twice to approximately 7 nm. DLarge appears to be built up from an assembly of cubosomic domains, which may coexist with an amphiphilic lamellae domain at low temperatures. The chemical stimulus concentration can be selected as to tune the hydration of the nanochannels in the DLarge phase and its transformation into a DNormal phase at temperatures above the body temperature. Two-dimensional SANS images recorded upon heating scan reveal growth of spontaneously oriented domains of single-crystal cubic nature. Phase separation and squeezing out the guest-hydrating agent from the higher-curvature regions of the amphiphilic bilayer suggest a possible mechanism for the established transformations. The order-order structural transition, cubic DLarge-cubic DNormal, is found to be reversible upon cooling. The obtained results put forward a structure-based concept for release of encapsulated guest molecules from stimuli-responsive and self-regulated cubosomic nanocarriers.
Development of Experimental Methodology for Highly Efficient Wafer-Level Evaluation of X-Ray Radiation Effects on Semiconductor Devices (2014)

A high-speed experimental method to evaluate the X-ray radiation damage of a large number of transistors has been developed. In this method, test-element groups (TEGs), including approximately 10,000 metal-oxide-semiconductor (MOS) transistors, were formed on a silicon-on-insulator (SOI) wafer and irradiated with X-rays using novel equipment. After irradiation, fuses on the wafer were cut to isolate each transistor, and the transistor characteristics were measured by an automatic probe station. This method can provide approximately 10,000 lines of I-V curves of the transistors under 31 irradiation dose conditions in 10 days. Radiation damages are known to largely depend on the bias voltage conditions of the devices. In this method, the TEGs are located apart from one another on the wafer; then, the X-ray doses and bias voltage can be controlled specifically by each TEG. Using this equipment, a large amount of experimental data can be effectively acquired. The statistical data analysis enables highly effective radiation-resistant semiconductor development and reliability examination.
Room-Temperature Spin-Transport Properties in an In0.5Ga0.5As Quantum Dot Spin-Polarized Light-Emitting Diode (2021)

An understanding of the spin-transport properties in semiconductor barriers is essential to improve the performance of spin-polarized light-emitting diodes (spin LEDs) for future optospintronics integration in information processing. Here, we report on the temperature and bias-voltage dependence of spin-transport properties in an ${\mathrm{In}}_{0.5}{\mathrm{Ga}}_{0.5}\mathrm{As}$ quantum dot (QD) spin LED using a combination of spin-dependent electroluminescence (EL) and time-resolved photoluminescence. The QD EL spin polarization increases with an increase in temperature above 125 K; this is attributed to the improved conversion efficiency from spin polarization of electrons to circular polarization of photons of the QDs. We find that both the electric field and temperature can enhance spin relaxation in the undoped $\mathrm{Ga}\mathrm{As}$ barrier above 200 K. At 298 K, the QD EL spin polarization decreases beyond 2.5 V; this is attributed to the enhanced D'yakonov Perel' spin relaxation in the undoped $\mathrm{Ga}\mathrm{As}$ barrier caused by the increase in electron temperature. This study provides valuable insights into the spin-relaxation mechanism in the semiconductor barrier during the room-temperature operation of the QD spin LED.
Transformation Induced Cyclic Behavior and Fatigue Properties of Nickel Rich NiTi Shape Memory Alloy Actuators (2013)

This chapter contains sections titled: Introduction Experimental setup and test matrix Fatigue tests results Conclusions Acknowledgments
New Nonlinear Optical Materials: Expedient Topotactic Self‐Assembly of Acentric Chromophoric Superlattices (1995)

High structural regularity, second-order nonlinear susceptibility, and thermal stability characterize the self-assembled stilbazolium chromophoric multilayers (the structure obtained after the first cycle is shown schematically on the right). A topotactic approach for the stilbazolium chromophore deposition has resulted in conceptually attractive, artificial, acentric assemblies for organic second-order nonlinear materials.
Evaluation of impact of energy storage on Effective Load Carrying Capability of wind energy (2012)

Wind energy is variable and intermittent in nature. The variations in wind speed results in a stochastic output for wind turbines. Therefore, the peak generation of wind farms and peak load demand typically do not occur at the same time. This paper studies a wind farm integrated with an energy storage device at turbine level in order to shift the wind power generation to the peak demand periods. A model of system including practical utility level battery integrated with wind farm is developed and presented. In order to measure the effect of this integration, actual profiles of load, wind energy, and other power sources is studied and the Effective Load Carrying Capability (ELCC) for wind energy, after and before adding the battery, is calculated. Results show that the battery can make significant improvements in the ELCC of wind energy.
Ultrasound coating of polydimethylsiloxanes with antimicrobial enzymes (2015)

There is an urgent need for antimicrobial functionalization of urinary catheters to prevent microbial colonization and biofilm formation on them. Here, the antimicrobial hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) producing enzyme cellobiose dehydrogenase (CDH) was for the first time grafted onto polydimethylsiloxanes (PDMS) using an ultrasound assisted coating method. This resulted in the development of an effective in situ continous H<sub>2</sub>O<sub>2</sub> producing system able to continuously prevent microbial colonization and biofilm formation on catheters. This enzyme has an added advantage that it uses various oligosaccharides including expolysaccharides (an important part of the bioflim produced by the microbes while colonizing biomaterials) as electron donors to produce H<sub>2</sub>O<sub>2</sub>. Successful immobilization of active CDH nanoparticles on PDMS was confirmed by ESEM and AFM analysis as well as quantification of H<sub>2</sub>O<sub>2</sub>. Depending on the initial enzyme concentration, CDH-nanoparticles of varying sizes from 65 ± 17 nm to 93 ± 17 nm were created by the ultrasonic waves and subsequently deposited on the PDMS surface. PDMS sheets treated for 3 min produced 18 μM of H<sub>2</sub>O<sub>2</sub> within 2 hours which was sufficient to significantly reduce the amount of viable S. aureus cells as well as the total amount of biomass deposited on the surface. The ultrasound assisted coating of antimicrobial enzymes therefore provides an easy approach to immobilize enzymes and create a surface with antimicrobial properties.
Oligomerization–transmetalation reactions of Cp*CrMe2(PMe3)/methylaluminoxane catalysts (2000)

Chain growth in the reaction of ethylene with Cp*CrMe2(PMe3) activated with methylaluminoxane is restricted by a fast Cr/Al transmetalation process.
Scaffolding depth cues and perceptual learning in VR to train stereovision: a proof of concept pilot study (2021)

Stereopsis is a valuable feature of human visual perception, which may be impaired or absent in amblyopia and/or strabismus but can be improved through perceptual learning (PL) and videogames. The development of consumer virtual reality (VR) may provide a useful tool for improving stereovision. We report a proof of concept study, especially useful for strabismic patients and/or those with reduced or null stereoacuity. Our novel VR PL strategy is based on a principled approach which included aligning and balancing the perceptual input to the two eyes, dichoptic tasks, exposure to large disparities, scaffolding depth cues and perception for action. We recruited ten adults with normal vision and ten with binocular impairments. Participants played two novel PL games (DartBoard and Halloween) using a VR-HMD. Each game consisted of three depth cue scaffolding conditions, starting with non-binocular and binocular cues to depth and ending with only binocular disparity. All stereo-anomalous participants improved in the game and most (9/10) showed transfer to clinical and psychophysical stereoacuity tests (mean stereoacuity changed from 569 to 296 arc seconds, P < 0.0001). Stereo-normal participants also showed in-game improvement, which transferred to psychophysical tests (mean stereoacuity changed from 23 to a ceiling value of 20 arc seconds, P = 0.001). We conclude that a VR PL approach based on depth cue scaffolding may provide a useful method for improving stereoacuity, and the in-game performance metrics may provide useful insights into principles for effective treatment of stereo anomalies.This study was registered as a clinical trial on 04/05/2010 with the identifier NCT01115283 at ClinicalTrials.gov.
Functional formal verification on designs of pSeries microprocessors and communication subsystems (2005)

This paper discusses our experiences and results in applying functional formal verification (FFV) techniques to the design of the IBM pSeries® microprocessor and communication subsystem. We describe the evolution of FFV deployment across several generations of this product line, including tool and algorithmic improvements, as well as methodological improvements for prioritizing the portions of the design that should be considered for formal verification coverage. Improvements made in the formal verification toolset, including the introduction of semiformal verification and bounded-model-checking algorithms, have allowed increasingly larger partitions to become candidates for formal coverage. Other tool enhancements, such as phase-abstraction techniques to deal with clock gating schemes, are presented. Overall, numerous complex design defects were discovered using formal techniques across the microprocessor and communication subsystem, many of which would likely have escaped to the test floor.