gebhart/patrepeval huggingface dataset:
A new dawn for industrial photosynthesis (2011)

Several emerging technologies are aiming to meet renewable fuel standards, mitigate greenhouse gas emissions, and provide viable alternatives to fossil fuels. Direct conversion of solar energy into fungible liquid fuel is a particularly attractive option, though conversion of that energy on an industrial scale depends on the efficiency of its capture and conversion. Large-scale programs have been undertaken in the recent past that used solar energy to grow innately oil-producing algae for biomass processing to biodiesel fuel. These efforts were ultimately deemed to be uneconomical because the costs of culturing, harvesting, and processing of algal biomass were not balanced by the process efficiencies for solar photon capture and conversion. This analysis addresses solar capture and conversion efficiencies and introduces a unique systems approach, enabled by advances in strain engineering, photobioreactor design, and a process that contradicts prejudicial opinions about the viability of industrial photosynthesis. We calculate efficiencies for this direct, continuous solar process based on common boundary conditions, empirical measurements and validated assumptions wherein genetically engineered cyanobacteria convert industrially sourced, high-concentration CO(2) into secreted, fungible hydrocarbon products in a continuous process. These innovations are projected to operate at areal productivities far exceeding those based on accumulation and refining of plant or algal biomass or on prior assumptions of photosynthetic productivity. This concept, currently enabled for production of ethanol and alkane diesel fuel molecules, and operating at pilot scale, establishes a new paradigm for high productivity manufacturing of nonfossil-derived fuels and chemicals.
Abstract 9762: Brain Tumor Necrosis Factor-α Augments Sympathoexcitation and Left Ventricular Remodeling of Ischemia-induced Heart Failure via Dysfunction of Keap1/Nrf2-mediated Antioxidant in Brain Astrocyte (2012)

[Backgrounds] We have demonstrated, in ischemic heart failure (HF), angiotensin II increases oxidative stress and induces apoptosis of brain astrocyte, sympathoexcitation and left ventricular (LV) remodeling. In astrocyte, the oxidant-sensing Keap1/NF-E2-related factor 2 (Nrf2) pathway mediates antioxidant function. Recent studies have indicated that brain proinflammatory cytokines also contribute to sympathoexcitation. The aim of the present study was to determine whether brain tumor necrosis factor (TNF)-α augments sympathoexcitation and LV remodeling caused by apoptosis of brain astrocyte in ischemia-induced HF, and if so, whether TNF-α impairs Keap1/Nrf2-mediated antioxidant function of brain astrocyte. [Methods and Results] We treated, for 4 weeks, Sprague-Dawley rats with HF (by coronary ligation) with a continuous intracerebroventricular infusion of angiotensin II type 1 receptor blocker (ARB), ARB+etanercept (ETN; TNF-a receptor blocker), vehicle (Veh) or sham. Urinary norepinephrine excretion (UNE; an index of sympathoexcitation), brain oxidative stress, and glial fibrillary acidic protein expression (GFAP; marker of astrocyte apoptosis) in the brain were significantly higher and LV end-systolic dimension (LVESD) were significantly larger in Veh than in sham (UNE; 2.3±0.3 μg/day vs. 1.1±0.2 μg/day, n=5 for each, p&lt;0.05). Brain Nrf2 expression was significantly lower in Veh than in Sham (0.3±0.1 U vs. 1.0 U, value is expressed relative to that in sham, n=5 for each, p&lt;0.05). In comparison to Veh, ARB lowered UNE (1.8±0.1 μg/day vs. 2.3±0.3 μg/day, n=5 for each, p&lt;0.05), brain oxidative stress, GFAP expression, and LVESD. Furthermore, all of these beneficial effects were augmented in ARB+ETN to the similar levels in sham (UNE; 1.4±0.2 μg/day, n=5). Brain Nrf2 expression was significantly higher in ARB+ETN than in Veh (0.7±0.1 U vs. 0.3±0.1 U, value is expressed relative to that in sham, n=5 for each, p&lt;0.05), although it was not different between in ARB and Veh. [Conclusion] Brain TNF-α augments angiotensin II-induced sympathoexcitation and LV remodeling of ischemia-induced HF via dysfunction of Keap1/Nrf2-mediated antioxidant in brain astrocyte.
New sustained release dosage form of chlorhexidine for dental use (1982)

The purpose of this study was to develop a sustained release dosage form of chlorhexidine diacetate for topical use. Cast films of ethyl cellulose with or without polyethylene glycol containing 5, 10, and 20 % of the drug were prepared and exhibited sustained release. Chloroform and ethanol were used as casting solvents. Release rate of chlorhexidine from the film was measured by means of a UV spectrophotometer, and kinetics of release were found to conform to Higuchi's diffusional model. This study demonstrates that by embedding chlorhexidine in polymeric films it is possible to obtain sustained release of the drug for several months.
Optimal pilot waveform assisted modulation for ultra-wideband communications (2003)

Performance of ultra-wideband (UWB) communication systems can be enhanced by collecting multipath diversity gains, once the channels are acquired at the receiver. In this paper, we develop a novel pilot waveform assisted modulation (PWAM) scheme that is tailored for power-limited UWB communications, and can be implemented in analog form. The PWAM parameters are designed to jointly optimize performance and information rate. The resulting transmitter design also minimizes the mean square error (MSE) of channel estimation and thereby achieves the Cramer-Rao lower bound (CRLB).
Response to: “Spinal cord stimulation: Stimulating questions” (2008)

1Life Bridge Health Brain & Spine Institute 5051 Greenspring Avenue, Baltimore, MD, USA 2The Neuromodulation Foundation, Inc., N/A, 117 East 25th Street, Baltimore, MD, United States *Corresponding author. Tel.: +1 410 601 1950. E-mail: [email protected] E-mail: [email protected]
Automatic calibration of time of flight based non-line-of-sight reconstruction (2021)

Time of flight based Non-line-of-sight (NLOS) imaging approaches require precise calibration of illumination and detector positions on the visible scene to produce reasonable results. If this calibration error is sufficiently high, reconstruction can fail entirely without any indication to the user. In this work, we highlight the necessity of building autocalibration into NLOS reconstruction in order to handle mis-calibration. We propose a forward model of NLOS measurements that is differentiable with respect to both, the hidden scene albedo, and virtual illumination and detector positions. With only a mean squared error loss and no regularization, our model enables joint reconstruction and recovery of calibration parameters by minimizing the measurement residual using gradient descent. We demonstrate our method is able to produce robust reconstructions using simulated and real data where the calibration error applied causes other state of the art algorithms to fail.
Multiprocessor main memory transaction processing (1988)

In this paper we describe an experiment designed to evaluate the potential transaction processing system performance achievable through the combination of multiple processors and massive memories. The experiment consisted of the design and implementation of a transaction processing kernel on stock multiprocessors. We found that with sufficient memory, multiple processors can greatly improve performance. A prototype implementation of the kernel on a pair of Firefly multiprocessors (each with five 1-MIP processors) runs the standard debit-credit benchmark at over 1000 transactions per second.
Long-Term Lamivudine Treatment is Associated with a Good Maintained Response in Severe Acute Exacerbation of Chronic Hbeag-Negative Hepatitis B (2006)

Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B is difficult to treat and there is little long-term data for lamivudine treatment of severe acute exacerbation. We report a prospective, consecutive cohort of severe acute exacerbation of HBeAg-negative chronic hepatitis B patients treated by lamivudine between 1999 and 2004. All patients had respectively increased alanine aminotransferase and serum bilirubin to at least 10 and 2 times the upper limit of laboratory normal. Thirty-two patients were treated with lamivudine for 130 +/- 58 (range 48-217) weeks. Five patients had evidence of virological breakthrough (HBV DNA >10,000 copies/ml) during lamivudine treatment. The cumulative probability of maintained response without any virological breakthrough was 94% (95% confidence interval [CI], 86-100%) at year 1, 94% (95% CI, 82-100%) at year 2 and 71% (95% CI, 41-100%) at year 3. At the last follow-up visit, 31 (97%) lamivudine patients had HBV DNA <10,000 copies/ml. The prevalence of lamivudine resistance mutation was 1 in 32 patients (3%; 95% CI, 0-9%) at year 1, 1 in 17 patients (6%; 95% CI, 0-17%) at year 2, 1 in 9 patients (11%, 95% CI, 0-32%) at year 3 and 1 in 4 patients (25%; 95% CI, 0-67%) at year 4 of lamivudine treatment. In conclusion, extended lamivudine treatment is associated with a high maintained virological response and a low rate of drug resistance in severe acute exacerbation of HBeAg-negative chronic hepatitis B.
Systém dálkové správy multifunkčních zařízení a tiskáren značky RICOH (2008)

This Bachelor work deals with system of remote monitoring of reprographic devices (copy machines, printers and multifunctional devices), for the purpose of improving customer service efficiency of Impromat - which is the official RICOH distributor (RICOH Company, Ltd., Japan) for the Czech market. The goal of the work is to find the optimal monitoring solution most suitable to Ricoh products and to Impromat operating structure, with regards to operating costs, data security and feasibility. The practical part of this work is dedicated to the implementation of the pilot project. The output is a proposal of inner processes and creation of system documentation for all of the departments in the company.
Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors (2004)

Dose-independent hypersensitivity reactions and dose-dependent thrombocytopenia limited tolerance of LErafAON. Future clinical evaluation of this approach will depend on modification of the liposome composition.
Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits. (1996)

Gomisin A (Go), a lignan component of shizandra fruits, protects the liver from injury by acetaminophen (AAP). One of its possible mechanisms is supposed to be related to the suppression of lipid peroxidation. Since hepatocyte growth factor (HGF) was reported to prevent hepatotoxin-induced liver damage, we tested HGF as the intermediary of Go effects. Simultaneous analyses of HGF mRNA expression and liver histology in rats were performed at 6 and 24 hr after treatment with AAP, Go or both. HGF mRNA rapidly expressed at 6 hr after Go treatment, while no HGF mRNA was observed at 6 hr after AAP treatment. Induction of HGF mRNA at 24 hr was observed after treatment with AAP or AAP plus Go. Histological findings indicate that massive necrosis and vacuolization in the liver of rats treated with both AAP and Go were reduced in comparison with rats treated with AAP only. These data suggest that Go rapidly induces HGF mRNA through different mechanisms from AAP-induced liver injury.
A fabrication process for the monolithic integration of magnetoelastic actuators and silicon sensors (2015)

This paper describes a microfabrication process that accommodates the design considerations of wirelessly actuated magnetoelastic traveling wave and standing wave motors that are integrated with capacitive position sensors on a silicon substrate. The process—which incorporates AuIn eutectic bonding, multiple deep reactive ion etching steps, and metal electrode deposition and etching—addresses the challenges of magnetoelastic layer attachment, multi-layer structures, and robust electrode isolation. Measurements of successfully fabricated devices show that the typical resonant frequencies of the clockwise and counterclockwise modes for the standing wave stators existed at 12.1 and 22.4 kHz with 0.44 µm and 0.4 µm out-of-plane amplitudes, respectively, when a ≈2 Oe amplitude ac magnetic field and a ≈6.5 Oe dc magnetic bias field were applied. For the as-fabricated traveling wave motors, two desired mode shapes with π/2 spatial phase shift existed at typical frequencies of 28.4 and 29.9 kHz, with typical out-of-plane amplitudes of 74 and 70 nm, respectively, when a ≈6 Oe amplitude ac magnetic field and a ≈3 Oe dc magnetic bias field were applied. The frequencies were tuned with added mass, resulting in a shift to 28.37 and 28.33 kHz with out-of-plane amplitudes of 80 and 60 nm for the two modes, respectively. After tuning, a traveling wave with a continuous direction of propagation was successfully demonstrated. The capacitive position sensing scheme showed a sensitivity of ≈0.5 pF per degree over 8°.
ELTRAN® (SOI-Epi wafer™) technology (2002)

This chapter has dealt quite exhaustively with a relatively new method of fabricating bonded SOI wafers. As in other SOI wafer bonding techniques that utilize epitaxially grown layers, such as BESOI and Smart Cut® with epi, crystal originating defects (COPs) should be a minor concern. Some key elements of the technique involve the growth of high quality epitaxial films on top of a porous silicon layer, made possible through the use of hydrogen induced smoothing of the surface and the splitting of the bonded pair using a water jet. This method should be compared to the hydrogen gas induced exfoliation of the SOI films, described in Chapter 3 on Smart Cut®, with which it shares some common characteristics; but there are important differences, notably the details of how the interfacial stress is induced. As with other wafer bonding techniques, attention to cleanliness and bonding environment are paramount. However, significant progress has been made since the early 1990s as outlined in this chapter and at the time of writing prototype production of SOI wafers has begun with plans to expand into 300 mm diameter wafers at the opportune time.
Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice (2022)

Deletion of both the Dectin-1 and Dectin-2 receptors triggered a global shift in the microbial gut environment, affecting, surprisingly, mainly the bacterial population and driving protective effects in colitis. Members of the Lachnospiraceae family seem to play a central role in this protection. These findings provide new insights into the role of the Dectin receptors, which have been described to date as affecting only the fungal population, in intestinal physiopathology and in IBD. Video Abstract.
CiteSight (2014)

A person often uses a single search engine for very different tasks. For example, an author editing a manuscript may use the same academic search engine to find the latest work on a particular topic or to find the correct citation for a familiar article. The author's tolerance for latency and accuracy may vary according to task. However, search engines typically employ a consistent approach for processing all queries. In this paper we explore how a range of search needs and expectations can be supported within a single search system using differential search. We introduce CiteSight, a system that provides personalized citation recommendations to author groups that vary based on task. CiteSight presents cached recommendations instantaneously for online tasks (e.g., active paper writing), and refines these recommendations in the background for offline tasks (e.g., future literature review). We develop an active cache-warming process to enhance the system as the author works, and context-coupling, a technique for augment sparse citation networks. By evaluating the quality of the recommendations and collecting user feedback, we show that differential search can provide a high level of accuracy for different tasks on different time scales. We believe that differential search can be used in many situations where the user's tolerance for latency and desired response vary dramatically based on use.
Recent trends in 8–14 μm type-II superlattice infrared detectors (2021)

Type-II superlattices (T2SLs) hold enormous potential for next-generation 8 – 14 μm long-wavelength infrared (LWIR) detectors for use at high operating temperature (HOT). The inherit flexibility of the material system has enabled the incorporation of unipolar barriers to eliminate generation-recombination currents and enhance device performance. In addition to suppressed Auger recombination and tunneling currents, this has led to sustained research interest in this material system over the past several decades. For these reasons, they are theoretically predicted to outperform the current state-of-the-art Mercury Cadmium Telluride (MCT) detectors. This review provides an overview of LWIR T2SL detectors and highlights some recent developments towards HOT applications. Recent studies on the minority carrier lifetime and diffusion length of T2SLs are examined to appraise the extent to which they limit the performance of HOT LWIR T2SL detectors. Strategies for mitigating these limitations are also explicated.
Bandwidth and Cache Leasing in Wireless Information Centric Networks: a Game Theoretic Study (2016)

Information-centric networking (ICN) is a novel paradigm that aims at improving the performance of today's Internet by supporting caching and multicast content delivery on every network device. The main contribution of this paper is to propose a centralized strategy to stimulate third parties to jointly lease the unused bandwidth and storage available on wireless access points (APs) in an ICN. We formulate this problem as a combinatorial reverse auction run by a content provider (CP) willing to increase the number of users reached by its service. We show that the optimal allocation with partial coverage problem is NP-hard, provide greedy heuristics that guarantee the individual rationality and truthfulness properties, and compare their performance numerically. We evaluate the benefits of our proposed mechanisms in terms of the cost savings for the CP obtained by offloading its infrastructure through the caches and the reduced computational time to execute the allocation algorithms. We compare the results obtained in this centralized setting with those that can be observed when the mobile clients autonomously choose which AP they prefer to use, among those activated by the auction mechanism. We model this second scenario as a congestion game, showing that it exhibits the desired properties (i.e., existence and uniqueness of a Nash equilibrium) and by comparing its social welfare with the centralized case.
Angiogenic Property of Hepatocyte Growth Factor Is Dependent on Upregulation of Essential Transcription Factor for Angiogenesis, ets-1 (2003)

Here, we demonstrated that HGF stimulated the expression of MMP-1, VEGF, HGF itself, and c-met in human endothelial cells and vascular smooth muscle cells. Upregulation of angiogenesis-related genes was largely dependent on the induction of ets, especially ets-1. These data provide new information about the mechanisms of angiogenesis.
Comparison of UWB Dual-Antenna Systems Using Diversity (2009)

International audience
A novel approach for designing GaAs FET frequency multipliers with optimum conversion gain and power efficiency (1992)

Abstract This article reports a new experimental design technique for GaAs FET frequency multipliers based on harmonic load‐pull measurements [1]. The choices of biasing point, input power level, and load impedances at the fundamental and harmonic frequencies are examined to optimize the conversion gain and the multiplier power efficiency. This technique was validated by designing a 2.5–7.5‐GHz frequency tripler, using the NE 71083 GaAs FET. The performance of the frequency tripler built in MIC technology was found comparable to the multiharmonic load‐pull results and simulation results. © 1992 John Wiley &amp; Sons, Inc.
In Vitro Study of HA and CMP Grit-Blasted and Acid Etched of Ti Surface (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Pulse wave measurement in human using piezoresistive cantilever on liquid (2015)

We propose a device that can measure pulse waves at various points on human body with high sensitivity. Pulse wave velocity was calculated from a synchronized pulse wave measurement on two points. The device had a piezoresistive cantilever placed on silicone oil. The cantilever with oil was embedded in polydimethylsiloxane (PDMS). Pressure waves from arteries can be well conveyed to the cantilever, for the human-skin-like acoustic impedance of the silicone oil and PDMS. The signal to noise ratio of the device was ~80 dB in 10-100 Hz, when excited ~1 μm in displacement.
Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis (2017)

A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%).
MiR‐1285‐5p/TMEM194A axis affects cell proliferation in breast cancer (2019)

The onset of breast cancer among young patients is a major issue in cancer etiology. Our previous study has shown that poor prognosis in young women with breast cancer is associated with lower expression of the microRNA miR-1285-5p. In this study, we showed that the expression of miR-1285-5p is lower in tumor tissues than in normal tissues. Accumulating evidence suggests that miR-1285-5p plays critical roles in various types of cancers. However, the functional role of miR-1285-5p in breast cancer remains to be elucidated. Here, we showed the tumor-suppressive role of miR-1285-5p and detailed its mechanism of action in breast cancer. Overexpression of miR-1285-5p significantly inhibited cell proliferation in breast cancer cells regardless of the tumor subtype. Among the target genes of miR-1285-5p, we found that transmembrane protein 194A (TMEM194A) was directly regulated by miR-1285-5p. Notably, separation of centrosomes from the nuclear envelope was observed upon knockdown of TMEM194A or overexpression of miR-1285-5p. In conclusion, our findings show that miR-1285-5p is a tumor suppressor via TMEM194A inhibition in breast cancer.