gebhart/patrepeval huggingface dataset:
The Trafficking and Processing of Insulin and Insulin Receptors in Cultured Rat Hepatocytes* (1987)

The processing and trafficking of insulin in cultured rat hepatocytes were studied. A time course of binding of radiolabeled insulin to hepatocytes at 37 C revealed a rapid rise in cell-associated radioactivity that reached a steady state by 20 min. Using an acid medium to extract insulin bound to surface receptors, the time courses of receptor binding and internalization of the ligand were characterized. The earliest event in insulin processing was the binding of insulin to surface receptors, reaching steady state by 20 min with a t1/2 of 4 min. The internalization rate of ligand was initially slower than the binding rate, with a t1/2 of 6 min. Similar internalization rates of the insulin receptor were found by measuring the trypsin sensitivity of hepatocyte insulin receptors covalently occupied with a photo-affinity-labeled derivative of insulin [( 125I]B2 (2-nitro-4-azido-phenylacetyl)Des-PheB1-insulin). At steady state, the internalized ligand and receptor comprised approximately 40-45% of the cell-associated radioactivity. The time course of intracellular degradation was assessed by trichloroacetic acid (TCA) precipitability and Sephadex G-50 gel chromatography of solubilized cells containing only internalized radioactivity. Intracellular TCA-soluble and low mol wt degradation products first appeared by 5 min and were released from the cell 3 min later. Chloroquine (100 microM) completely inhibited the formation of intracellular low mol wt degradation products as well as their appearance in the medium. The release of intracellular radioactivity was assessed by first removing surface-bound insulin with acid extraction. Eighty percent of the intracellular radioactivity was released in 45 min with a t1/2 of 8 min. The released radioactivity was assessed by TCA precipitability and gel chromatography. These results demonstrate that after 20 min, 43% of the released intracellular radioactivity is intact insulin. The percentage of intact insulin released increases in a dose-dependent fashion as the amount of insulin bound and internalized increases. In conclusion, the earliest event in insulin processing is binding to surface receptors. After a short delay, insulin and its receptor are internalized and trafficked into either a chloroquine-sensitive degradative pathway or a chloroquine-insensitive retroendocytotic pathway. The amount of insulin that traverses the nondegradative retroendocytotic pathway is proportional to the amount of insulin bound and internalized by the cell.
Critical Components of Biofilm Models for Engineering Practice (2010)

de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Power system state estimation via feasible point pursuit (2016)

Power system state estimation (PSSE) is a critical task for grid operation efficiency and system stability. Physical laws dictate quadratic relationships between observable quantities and voltage state variables, hence rendering the PSSE problem nonconvex and NP-hard. Existing SE solvers largely rely on iterative optimization methods or semidefinite relaxation (SDR) techniques. Even when based on noiseless measurements, convergence of the former is sensitive to the initialization, while the latter is challenged by small-size measurements especially when voltage magnitudes are not available at all buses. At the price of running time, this paper proposes a novel feasible point pursuit (FPP)-based SE solver, which iteratively seeks feasible solutions for a nonconvex quadratically constrained quadratic programming reformulation of the weighted least-squares (WLS) SE problem. Numerical tests corroborate that the novel FPP-based SE markedly improves upon the Gauss-Newton based WLS and SDR-based SE alternatives, also when noisy measurements are available.
Simplified technique for polarization-sensitive optical coherence tomography (2001)

We have developed a fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system using non- polarization-maintaining fiber and a single detector, in which the polarization-sensitive components are implemented entirely in bulk optics in the sample arm.
Doppler laser radar for measuring target range and speed with high precision (2011)

In this paper, we describe an in-car laser radar schematic diagram, and propose a new modulation scheme for the in-car laser radar measuring target range and speed with high precision simultaneously. Then, we perform experiments to verify the correctness of the proposed method.
ChemInform Abstract: Preparation of Pyrrolidine and Isoxazolidine Benzamidines as Potent Inhibitors of Coagulation Factor Xa. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Micromechanical properties of colloidal structures (2013)

The production, further processing as well as the product properties of nanostructured aggregates and colloidal films are specified by characteristics of the particles and particle structures. Especially, the effect of the colloidal structure on the micromechanical properties is of particular interest. The investigation of this structure-micromechanical property relationship was the main objective of this study. Therefore, the colloidal structure and micromechanical properties of silica model aggregates and colloidal PMMA films were analyzed and compared to theoretical considerations and simulations of the deformation and fracture behavior using the discrete elements method.
NViSII: A Scriptable Tool for Photorealistic Image Generation (2021)

We present a Python-based renderer built on NVIDIA's OptiX ray tracing engine and the OptiX AI denoiser, designed to generate high-quality synthetic images for research in computer vision and deep learning. Our tool enables the description and manipulation of complex dynamic 3D scenes containing object meshes, materials, textures, lighting, volumetric data (e.g., smoke), and backgrounds. Metadata, such as 2D/3D bounding boxes, segmentation masks, depth maps, normal maps, material properties, and optical flow vectors, can also be generated. In this work, we discuss design goals, architecture, and performance. We demonstrate the use of data generated by path tracing for training an object detector and pose estimator, showing improved performance in sim-to-real transfer in situations that are difficult for traditional raster-based renderers. We offer this tool as an easy-to-use, performant, high-quality renderer for advancing research in synthetic data generation and deep learning.
IEEE 802.11be Extremely High Throughput: The Next Generation of Wi-Fi\n Technology Beyond 802.11ax (2019)

Wi-Fi technology is continuously innovating to cater to the growing customer\ndemands, driven by the digitalisation of everything, both in the home as well\nas the enterprise and hotspot spaces. In this article, we introduce to the\nwireless community the next generation Wi-Fi$-$based on IEEE 802.11be Extremely\nHigh Throughput (EHT)$-$, present the main objectives and timelines of this new\n802.11be amendment, thoroughly describe its main candidate features and\nenhancements, and cover the important issue of coexistence with other wireless\ntechnologies. We also provide simulation results to assess the potential\nthroughput gains brought by 802.11be with respect to 802.11ax.\n
Singlet−Triplet Gap, and the Electronic and Vibrational Spectra of Chlorophenylcarbene:  A Combined Theoretical and Experimental Study (1999)

Minimum energy structures of singlet and triplet chlorophenylcarbene, a prototypical carbene, were computed. The singlet−triplet energy separation was predicted to be 7.84 and 7.70 kcal/mol at the UCCSD(T)/6-31+G* and QCISD(T)/6-31+G** levels of theory, respectively, after zero-point correction. This is slightly larger than that predicted by the CAS(6,6) (4.5 kcal/mol), local spin density approximation (5.6 kcal/mol), and the BLYP (7.3 kcal/mol) methods with the 6-31G* basis set reported by Trindle et al. The UV−vis and IR spectra of chlorophenylcarbene were analyzed with the aid of the CASPT2/CASSCF(10,10) and the B3LYP/6-31G* levels of theory, respectively. The UV−vis and IR spectra of chlorophenylcarbene were assigned on the basis of these calculations. The ab initio calculations predicted the existence of strong absorption bands in the UV and a weak band in the visible in good agreement with published spectra. The long (750 nm) wavelength band corresponds to electron promotion from the lone pair σ (HOMO) to the π* (LUMO). On the basis of the calculated harmonic frequencies, we cannot assign the 1244 and 1600 cm-1 IR bands observed in an argon matrix to chlorophenyl carbene. The most intense IR band (1225 cm-1) corresponds to the symmetric C−C stretch of the carbene and aromatic carbon. The asymmetric and symmetric C−C−Cl stretches are assigned to the bands observed at 847 and 739 cm-1, respectively.
ChemInform Abstract: STICKSTOFF‐HETEROCYCLEN AUS CIS‐DIBENZOYLSTILBEN UND UND DIAMINEN (1971)

Abstract Die Umsetzung von cis‐Dibenzoylstilben (VIII) (in Eisessig oder Eisessig/Methanol unter Rückfluß) mit einem Überschuß aromatischer Diamine, wie z.B. 0‐ Phenylendiamin, 2,3‐Diamino‐naphthalin, 3,4,3′,4′‐Tetramino‐biphenyl, 1,8‐Diamino‐naphthalin bzw. 2,2′‐Diamino‐biphenyl, führt zu den Heterocyclen (I) (80% Ausbeute) (II) (80%), (III) (60%), (IV) (85%) bzw. (V) (85%) mit Brückenkopf‐Stickstoff.
Sub-Carrier Snr Estimation At The Transmitter For Reduced Feedback Ofdma (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
Photocatalytic polymers of intrinsic microporosity for hydrogen production from water (2021)

Conjugated polymers of intrinsic microporosity show excellent performance as photocatalysts for sacrificial hydrogen production from water as they combine extended conjugation with high surface areas.
First Diastereoselective Intramolecular Baylis−Hillman Reaction:  An Easy Access to Chiral α-Methylene-β-hydroxylactones (2004)

The first diastereoselective intramolecular Baylis-Hillman reaction of chiral substrates is reported wherein both aldehyde and activated olefin coexist as substituents to afford alpha-methylene-beta-hydroxylactones in good yields exclusively as single isomers under the standard base-catalyzed reaction conditions in CH(2)Cl(2). Formation of alkoxylactones by an in situ derivatization of adducts was also observed.
Trap-level-engineered common red layer for fabricating red, green, and blue subpixels of full-color organic light-emitting diode displays (2015)

We report a novel strategy to reduce one fine metal mask (FMM) step in a full-color organic light-emitting diode (OLED) display by introducing a common red layer (CRL) which replaces a hole transporting layer (HTL) with the same thickness of a red phosphorescent dye-doped layer. Because the dopant in the HTL acts as a hole trap, careful trap-level engineering is required for achieving efficient green and blue emission from the emitting layer while minimizing the red emission from the CRL. We investigated the characteristics of OLEDs depending on hole trap levels of the CRL with five different organic HTLs, and demonstrated efficient red, green and blue (RGB) emitting devices using the CRL. The electroluminescence spectrum of the devices with the CRL is nearly identical with those of the devices without the CRL. These results open up the possibility of simplified fabrication of practical full-color OLED displays with the reduced FMM steps, resulting in lower manufacturing cost.
FRACTAL DIMENSION FOR POINCARÉ RECURRENCES AS AN INDICATOR OF SYNCHRONIZED CHAOTIC REGIMES (2000)

The studies of the phenomenon of chaos synchronization are usually based upon the analysis of the existence of transversely stable invariant manifold that contains an invariant set of trajectories corresponding to synchronous motions. In this paper we develop a new approach that relies on the notions of topological synchronization and the dimension for Poincaré recurrences. We show that the dimension of Poincaré recurrences may serve as an indicator for the onset of synchronized chaotic oscillations. This indicator is capable of detecting the regimes of chaos synchronization characterized by the frequency ratio p:q.
Data Supplement from Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFNγ-Dependent Cell-Cycle Arrest (2023)

&lt;p&gt;The infiltration of CTLs into the tumor inhibited the tumor growth by both cytolytic and cytostatic activities.&lt;/p&gt;
Patient-Reported Symptom Relief Following Medical Cannabis Consumption (2018)

<b>Background:</b> The Releaf App<sup>TM</sup> mobile software application (app) data was used to measure self-reported effectiveness and side effects of medical cannabis used under naturalistic conditions. <b>Methods:</b> Between 5/03/2016 and 12/16/2017, 2,830 Releaf App<sup>TM</sup> users completed 13,638 individual sessions self-administering medical cannabis and indicated their primary health symptom severity rating on an 11-point (0-10) visual analog scale in real-time prior to and following cannabis consumption, along with experienced side effects. <b>Results:</b> Releaf App<sup>TM</sup> responders used cannabis to treat myriad health symptoms, the most frequent relating to pain, anxiety, and depressive conditions. Significant symptom severity reductions were reported for all the symptom categories, with mean reductions between 2.8 and 4.6 points (ds ranged from 1.29-2.39, <i>p</i>s < 0.001). On average, higher pre-dosing symptom levels were associated with greater reported symptom relief, and users treating anxiety or depression-related symptoms reported significantly more relief (ps < 0.001) than users with pain symptoms. Of the 42 possible side effects, users were more likely to indicate and showed a stronger correlation between symptom relief and experiences of positive (94% of sessions) or a context-specific side effects (76%), whereas negative side effects (60%) were associated with lessened, yet still significant symptom relief and were more common among patients treating a depressive symptom relative to patients treating anxiety and pain-related conditions. <b>Conclusion:</b> Patient-managed cannabis use is associated with clinically significant improvements in self-reported symptom relief for treating a wide range of health conditions, along with frequent positive and negative side effects.
Concussion in Professional Football: Recovery of NFL and High School Athletes Assessed by Computerized Neuropsychological Testing—Part 12 (2006)

Computer-based neuropsychological testing was used within the overall medical evaluation and care of NFL athletes. As found in a prior study using more traditional neuropsychological testing, NFL players did not demonstrate decrements in neuropsychological performance beyond one week of injury. High school players demonstrated more prolonged neuropsychological effects of concussion.
Persistence of Transmitted Drug Resistance among Subjects with Primary Human Immunodeficiency Virus Infection (2008)

Following interruption of antiretroviral therapy among individuals with acquired drug resistance, preexisting drug-sensitive virus emerges relatively rapidly. In contrast, wild-type virus is not archived in individuals infected with drug-resistant human immunodeficiency virus (HIV) and thus cannot emerge rapidly in the absence of selective drug pressure. Fourteen recently HIV-infected patients with transmitted drug-resistant virus were followed for a median of 2.1 years after the estimated date of infection (EDI) without receiving antiretroviral therapy. HIV drug resistance and pol replication capacity (RC) in longitudinal plasma samples were assayed. Resistance mutations were characterized as pure populations or mixtures. The mean time to first detection of a mixture of wild-type and drug-resistant viruses was 96 weeks (1.8 years) (95% confidence interval, 48 to 192 weeks) after the EDI. The median time to loss of detectable drug resistance using population-based assays ranged from 4.1 years (conservative estimate) to longer than the lifetime of the individual (less conservative estimate). The transmission of drug-resistant virus was not associated with virus with reduced RC. Sexual transmission of HIV selects for highly fit drug-resistant variants that persist for years. The prolonged persistence of transmitted drug resistance strongly supports the routine use of HIV resistance genotyping for all newly diagnosed individuals.
Increased alveolar soluble annexin V promotes lung inflammation and fibrosis (2015)

The causes underlying the self-perpetuating nature of idiopathic pulmonary fibrosis (IPF), a progressive and usually lethal disease, remain unknown. We hypothesised that alveolar soluble annexin V contributes to lung fibrosis, based on the observation that human IPF bronchoalveolar lavage fluid (BALF) containing high annexin V levels promoted fibroblast involvement in alveolar epithelial wound healing that was reduced when annexin V was depleted from the BALF. Conditioned medium from annexin V-treated alveolar epithelial type 2 cells (AEC2), but not annexin V per se, induced proliferation of human fibroblasts and contained pro-fibrotic, IPF-associated proteins, as well as pro-inflammatory cytokines that were found to correlate tightly (r>0.95) with annexin V levels in human BALF. ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium. In vivo, aerosol delivery of annexin V to mouse lung induced inflammation, fibrosis and increased hydroxyproline, with activation of Wnt, transforming growth factor-β, mitogen-activated protein kinase and nuclear factor-κB signalling pathways, as seen in IPF. Chronically increased alveolar annexin V levels, as reflected in increased IPF BALF levels, may contribute to the progression of IPF by inducing the release of pro-fibrotic mediators.
Joint optimal beamforming and power control in cell-free massive MIMO (2022)

We derive a fast and optimal algorithm for solving practical weighted max-min SINR problems in cell-free massive MIMO networks. For the first time, the optimization problem jointly covers long-term power control and distributed beam-forming design under imperfect cooperation. In particular, we consider user-centric clusters of access points cooperating on the basis of possibly limited channel state information sharing. Our optimal algorithm merges powerful power control tools based on interference calculus with the recently developed team theoretic framework for distributed beamforming design. In addition, we propose a variation that shows faster convergence in practice.
Static progressive stretch improves range of motion in arthrofibrosis following total knee arthroplasty (2009)

Arthrofibrosis is a relatively common complication after total knee arthroplasty that negatively affects function and quality of life. Static progressive stretching is a technique that has shown promising results in the treatment of contractures of the elbow, ankle, wrist and knee. This study evaluated a static progressive stretching device as a treatment method for patients who had refractory knee stiffness after total knee arthroplasty. Twenty-five patients who had knee stiffness and no improvement with conventional physical therapy modalities were treated with the device. After a median of 7 weeks (range, 3-16 weeks), the median increase in range of motion was 25 degrees (range, 8-82 degrees). The median gain in knee active flexion was 19 degrees (range, 5-80 degrees). Ninety-two percent of patients were satisfied with the results. The authors believe static progressive stretching devices may be an effective method for increasing the ranges of motion and satisfaction levels of patients who develop arthrofibrosis after total knee arthroplasty.
광 네트워크를 위한 Hybrid 스위칭 시스템의 성능 분석 (2003)

본 논문에서 광 네트워크에서 광 버스트 스위칭(Optical Burst Switching, OBS)과 광 회선 스위칭(Optical Circuit Switching, OCS) 기술의 장점을 동시에 가지는 새로운 광 hybrid 스위칭(Optical Hybrid Switching) 시스템을 제안한다. 이 시스템은 들어오는 IP 트래픽을 hybrid 스위칭을 위해 짧은(short-lived) 흐름과 긴(long-lived) 흐름 구분한다. 성능 분석을 위하여 시스템을 Markovian 환경에서 단일 서버 큐로서 모델링 한다. 버스트 생성 프로세스는 two-state Markov Modulated Poisson Process (MMPP)를 따른다고 가정하고 서비스 율은 동시에 발생하는 OCS 세션의 수에 따라 변한다. OBS 버스트에 대한 평균 지연 및 큐 사이즈의 결과를 보인다.
Reactivity and Product Selectivity of Fluoroalkyl Carbonates in Substitution Reactions with Primary Alcohols and Amines (2022)

The present study reports a systematic investigation of the substitution reactions of a series of symmetric and unsymmetric fluoroalkyl carbonates with primary alcohols or amines. The reactivity of the haloalkyl carbonate depends mainly on the electrophilicity and steric crowdedness of the carbonyl group and the leaving ability of the haloalkyl alcohols. Diethyl carbonate as a reference substrate showed no reaction with the alcohol or amine. However, bis(2,2,2-trifluoroethyl) carbonate [(F<sub>3</sub>-EtO)<sub>2</sub>CO] having electron-withdrawing trifluoroethyl groups enabled substitution reactions, with relatively higher reactivities to those for diphenyl carbonate [(PhO)<sub>2</sub>CO]. Furthermore, (F<sub>6</sub>-<i>i</i>PrO)<sub>2</sub>CO, bearing two sets of hexafluoroisopropyl groups, showed dramatic acceleration of the reactions, in which the observed reactivities were similar to those for bis(perfluorophenyl) carbonate [(F<sub>5</sub>-PhO)<sub>2</sub>CO]. The electrophilicity of the carbonyl group and the leaving ability of the alcohols in the series of haloalkyl carbonates were found to be correlated with the wavenumbers of their carbonyl groups in IR spectra and p<i>K</i><sub>a</sub> for the eliminated alcohols, respectively. Since the eliminated fluoroalkyl alcohols exhibit weak affinity with the organic products and have lower boiling points owing to a characteristic property of the fluoroalkyl group, they could be readily removed from the product by simple evaporation below 100 °C with or without reduced pressure.
Fluidity Evolution of an Al-10%B<sub>4</sub>C Metal Matrix Composite (2007)

Aluminum boron carbide particulate reinforced composites are advanced materials which have superior mechanical properties, and especially have the capability to capture neutrons. The liquid mixing process is one of the methods to produce economically and effectively the metal matrix composites. However, it was found that the fluidity of the composites was instable during liquid holding and casting. To examine the fluidity evolution over the time, the melt of an Al-10%B4C composite was hold at a constant temperature for a long period, and the fluidity was evaluated by means of a vacuum fluidity test. The microstructure of the fluidity test samples was examined by optical and electron microscopes. It is found that the interfacial reaction products between B4C and Al-matrix play an important role for the deterioration of the composite fluidity.
Possible Outbreak of Streptomycin-ResistantMycobacterium tuberculosisBeijing in Benin (2009)

Using geographic information system and molecular tools, we characterized a possible outbreak of tuberculosis caused by Mycobacterium tuberculosis Beijing strain in 17 patients in Cotonou, Benin, during July 2005-October 2006. Most patients lived or worked in the same area and frequented the same local drinking bar. The isolates were streptomycin resistant.