gebhart/patrepeval huggingface dataset:
Key-value store with internal key-value storage interface (2023)

A key-value store is provided having one or more key-value storage interfaces. A key-value store on at least one compute node comprises a memory for storing a plurality of key-value pairs; and an abstract storage interface comprising a software interface module that communicates with at least one persistent storage device providing a key-value interface for persistent storage of one or more of the plurality of key-value pairs, wherein the software interface module provides the one or more key-value pairs to the at least one persistent storage device in a key-value format. The abstract storage interface optionally processes one or more batch operations on the plurality of key-value pairs. A distributed embodiment for a partitioned key-value store is also provided.
Abstract 14254: Pharmacodynamic Effects of a Single Dose of CK-3773274 in Cats With Hypertrophic Cardiomyopathy (2020)

Introduction: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular (LV) hypertrophy in the absence of known causes. HCM can be due to genetic mutations that affect sarcomeric proteins, leading to myocardial hypercontractility. HCM is often complicated by left ventricular outflow tract obstruction (LVOTO) and patients may be at greater risk of cardiovascular death. Medications targeted to address the pathophysiology of HCM and ameliorate LVOTO are needed. CK-3773274 (CK-274) is a novel small molecule cardiac myosin inhibitor that reduces myocardial contractility in vitro and in vivo . Cats have naturally occurring HCM commonly complicated by LVOTO and are an excellent large animal model for investigation of HCM therapeutics. In this study, we aim to characterize the pharmacodynamic effect of a single oral dose of CK-274 on cardiac function in cats with hypertrophic cardiomyopathy and LVOTO. Methods: Eight purpose-bred cats with naturally occurring HCM and LVOTO due to the A31P mutation in cardiac myosin binding protein C (cMyBP-C) were included in a randomized, controlled, crossover study. Cats were randomized to receive vehicle, 0.3 mg/kg, or 1 mg/kg CK-274 treatment, and received echocardiograms at baseline, 6, 24, and 48 hours post-treatment. All cats were crossed over to all treatment groups. Results: CK-274 (1 mg/kg) reduced mean LV fractional shortening at 6, 24 and 48 hours post-treatment (mean reduction 13.6%, p=0.03; 15.4%, p=0.01; 11.6% p=0.02, respectively). CK-274 (1 mg/kg) increased LV systolic internal dimension at 6 and 24-hours post-treatment (mean increase 0.21 cm, p=0.046; 0.25 cm, p=0.03), and did not affect LV diastolic internal dimension. LVOT peak pressure gradient was reduced with CK-274 (0.3 mg/kg) treatment [median pressure gradient at baseline 27.1 mmHg (IQR 18.3-33.3) vs 24 hours post-drug, 7.3 mmHg (IQR 14.2-19.7) p=0.01]. Heart rate did not change for any treatment group over time. No differences were noted following vehicle administration at any time point. Conclusion: In HCM affected cats with the cMyBP-C A31P mutation, the cardiac myosin inhibitor CK-274 is well tolerated at the studied doses and caused dose-related changes in LV systolic function and reductions in LVOT peak pressure gradient.
Supplementary Figure S7 from Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors (2023)

&lt;p&gt;Supplementary Figure S7&lt;/p&gt;
Nano-micro filled conductive adhesive based 3D micro arrays for Z-axis interconnections (2008)

This paper discusses nano-micro filled electrically conductive adhesive (ECA) based 3D micro array interconnects to connect multiple electronic layers. Adhesives formulated using controlled-sized particles, ranging from nanometer scale to micrometer scale, were used to form micro arrays of contact pads having diameters ranging from 5 mum to 300 mum for internal and external interconnect applications. SEM and optical microscopy were used to investigate the micro-structure, and conducting and sintering mechanisms. This work also discusses micro-filled epoxy-based conducting adhesives modified with nanoparticles for low temperature sintering. A variety of nanoparticles ranging from 10-15 nm was used to modify micro adhesive composites. Addition of in-situ nanoparticles reduces sintering temperature without compromising electrical conductivity. Adhesives exhibited volume resistivity ranging from 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> ohm-cm to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> ohm-cm, depending on composition, particle size, and loading of the adhesives. It was found that with increasing curing temperature of the adhesive, the volume resistivity decreased due to sintering of metal particles. Adhesives modified with nanoparticles or in-situ nanoparticles showed 30-90% resistance drop when cured at 240-265 degC instead of 200 degC. A few optimized metal-epoxy adhesives were used for hole fill applications to fabricate Z-axis interconnections in laminates. Conductive joints were formed during composite lamination using the ECA. Around 5,000 to 200,000 through holes in the joining cores, formed by laser or mechanical drilling, and having diameters ranging from 50 mum to 300 mum, were filled with an optimized conducting adhesive. The adhesive-filled joining cores were laminated with circuitized subcomposites to produce a composite structure. High temperature/pressure lamination was used to cure the adhesive in the composite and provide Z-interconnection among the circuitized subcomposites. A variety of joining core and subcomposite structures such as OS/IP, 0S/2P, 2S/1P, 2S/2P were used for hole fill applications. As a case study, an example of nano-micro filled conductive adhesives used in a z-axis interconnect construction of a 26 metal layer package with a 300 mum pad pitch is given. The present work describes processing of conductive adhesives used to achieve smaller feature dimensions, satisfy stringent registration requirements, and achieve robust electrical interconnections.
A surface flattening method for characterizing the surface stress, drained Poisson's ratio and diffusivity of poroelastic gels (2021)

When a poroelastic gel is released from a patterned mold, surface stress drives deformation and solvent migration in the gel and flattens its surface profile in a time-dependent manner. Specifically, the gel behaves like an incompressible solid immediately after removal from the mold, and becomes compressible as the solvent is able to squeeze out of the polymer network. In this work, we use the finite element method (FEM) to simulate this transient surface flattening process. We assume that the surface stress is isotropic and constant, the polymer network is linearly elastic and isotropic, and that solvent flow obeys Darcy's law. The short-time and long-time surface profiles can be used to determine the surface stress and drained Poisson's ratio of the gel. Our analysis shows that the drained Poisson's ratio and the diffusivity of the gel can be obtained using interferometry and high-speed video microscopy, without mechanical measurement.
The AFRL-MITLL WMT17 Systems: Old, New, Borrowed, BLEU (2017)

This paper describes the AFRL-MITLL machine translation systems and the improvements that were developed during the WMT17 evaluation campaign. This year, we explore the continuing proliferation of Neural Machine Translation toolkits, revisit our previous data-selection efforts for use in training systems with these new toolkits and expand our participation to the Russian-English, Turkish-English and Chinese-English translation pairs.
Analysis and selection of optimal function implementations in massively parallel computer (2023)

An apparatus, program product and method optimize the operation of a parallel computer system by, in part, collecting performance data for a set of implementations of a function capable of being executed on the parallel computer system based upon the execution of the set of implementations under varying input parameters in a plurality of input dimensions. The collected performance data may be used to generate selection program code that is configured to call selected implementations of the function in response to a call to the function under varying input parameters. The collected performance data may be used to perform more detailed analysis to ascertain the comparative performance of the set of implementations of the function under the varying input parameters.
Improvements in the Efficiency of Ocean Bottom Sensor Surveys through the Use of Multiple Independent Seismic Sources (2014)

Summary Improving the efficiency of ocean bottom sensor (OBS) surveys has been a long time goal of both oil companies and acquisition contractors. Full azimuth and offset OBS surveys have historically been time consuming to acquire due to limitations in the amount of equipment and the efficiency of the crews. A large increase in efficiency can be realized through the use of multiple independent source vessels working simultaneously. The field of Compressive Sensing (CS) provides the necessary framework to allow the vessels to work simultaneously and be able to produce comparable data sets to a traditionally acquired OBS survey. We describe the operational issues of acquiring a survey with multiple source vessels including the CS techniques used.
Nanoconfinement effects of chemically reduced graphene oxide nanoribbons on poly(vinyl chloride) (2018)

Polymeric nanocomposites with graphene-based nanocarbons (GNCs) have been extensively studied with emphasis on the percolation of nanofillers toward electrical, rheological, and mechanical reinforcement. In this study, we report an unusual indirect reinforcing phenomenon of highly defective GNCs dispersed in the poly(vinyl chloride) (PVC) matrix via densification of the polymer packing originating from nanoscale confinement. Herein, chemically reduced graphene oxide nanoribbons (C-rGONRs) are employed as a nanofiller. The inclusion of defective and oxygen-functionalized C-rGONRs resulted in a dramatic densification of the PVC host with extremely low C-rGONR loading, largely exceeding the theoretical calculation from a rule of mixture. Along with the densification, the glass transition temperature of PVC also increased by 28.6 °C at 0.1 wt% filler loading. Remarkably, the oxygen barrier property and mechanical toughness under tension for the PVC/C-rGONR nanocomposite were the maximum when the greatest densification occurred. The structure-property relationship of the nanocomposites has been discussed with an emphasis on the nanoscale confinement phenomenon.
Procalcitonin as a prognostic marker in patients with acute myocardial infarction (2010)

Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.
18F-FPRGD2 PET/CT Imaging of Integrin αvβ3 in Renal Carcinomas: Correlation with Histopathology (2015)

(18)F-FPRGD2 uptake reflects the expression of integrin αvβ3 in renal tumors but represents angiogenesis only when tumor cells do not express the integrin.
UAV-based Maritime Communications: Relaying to Enhance the Link Quality (2023)

Providing a stable connectivity in maritime communications is of utmost importance to unleash the full potential of smart ports. Nonetheless, due to the crowded nature of harbor environments, it is likely that some ships are shadowed by others, resulting in reduced received power that subsequently diminishes their data rates-even threatens basic connectivity requirements. Given that uncrewed aerial vehicles (UAVs) have been regarded as an integral part of future generations of wireless communication networks, they can be employed in maritime communications as well. In this paper, we investigate the use of UAV-mounted relays in order to help mitigate the reduced data rates of blocked links in maritime communications. Various communication architectures are considered based on the positioning mechanism of the UAV; in this regard, fixed, k-means algorithm-based, and landing spot-based positioning approaches are examined. Additionally, since UAVs are predominantly battery-operated, the energy consumption performances of these approaches are also measured. Results reveal that the landing spot-based UAV relay positioning approach finds the best trade-off between the data rate and energy consumption.
ChemInform Abstract: Rapid, Efficient, Room Temperature Aromatization of Hantzsch‐1,4‐dihydropyridines with Vanadium(V) Salts: Superiority of Classical Technique versus Microwave Promoted Reaction. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Estimation of the mechanical strength of nanotube bundle (2001)

Mechanical strength of a nanotube bundle has been measured by using quartz glass enclosed-purified SWNTs as the specimen. These specimens were prepared by fast stretching quartz glass tube that contained purified nanotube bundles, at temperatures ranging from 900 to 1490 °C. The maximum average critical load was 42.3 kg/mm2 for the specimen prepared at 900 °C. However, at temperatures higher than 900 °C, the critical load value decreased and became almost equal to that of quartz glass at 1490 °C. It was believed that the decrease in the critical load value at temperatures higher than 900 °C was due to the partial conversion of nanotubes into amorphous carbon. Since the cross-sectional area used in arriving at the critical load value was that of nanotube and the quartz glass, the cross-sectional area ratio of the quartz to that of the nanotube suggested that the mechanical strength of nanotube would be two orders of magnitude higher than the value reported here.
Regulation and compensation of source harmonics for the boost converter-based power factor precompensator (2002)

In this paper, the authors present an adaptive controller for the boost-based power factor precompensator which guarantees fast regulation of the output voltage towards a desired constant value with a power factor close to unity. This twofold control objective is fulfilled even in the presence of harmonics on the voltage source and uncertainties on the system parameters and load. The key for the solution to this problem is to express the model in terms of the input current instead of the inductor current. The resulting controller is reduced, through transformations, to the cascade interconnection of two controllers, namely the inner and the outer control loop. It is shown that while the latter turns out to be a simple lead-lag plus integration, the former is composed mainly of second order filters tuned at the frequencies of the considered harmonics and with transfer functions that follow a well defined pattern. Simulations are provided to assess the performance of the proposed controller.
Distance-incorporated opportunistic scheduling (2009)

This paper highlights the deficiencies of classical figures of merit such as throughput and fairness index to evaluate different scheduling algorithms and proposes a new complementary figure of merit called as transport-throughput, which has been inspired from information theory literature to better represent trade-offs among throughput, fairness and coverage associated with a given scheduling algorithm. Furthermore, new objective functions for opportunistic scheduling are proposed that utilize the knowledge about the geographic distance of mobile terminals from the base station. The proposed concept can be easily integrated as an extension to classical scheduling algorithms and provides the ability to control the effective distribution of throughput across the network
Skeletal effects of Oxytocin and Vasopressin (2018)

Over the last decade, the relevance of the pituitary-bone axis has been recognized.  Oxytocin (OXT), arginine vasopressin (AVP), growth hormone (GH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH) and prolactin have a dominant action on the skeleton as demonstrated by the fact that genetically modified mice lacking their ligands or receptors exhibit a skeletal phenotype, although the primary target organs remain unaltered.  Unraveling these new mechanisms of action of the pituitary hormones has paved the way for new therapeutic opportunities in the treatment of osteoporosis.  Here, we summarize the action and interaction of OXT and AVP, closely related small peptides that modulate reciprocal secretion and receptor expression on bone cells, in the physiologic context of the skeletal homeostasis.
Surface Energy Characterization for Die-Level Cu Hybrid Bonding (2022)

The characteristics and quality of the bonding interface in hybrid bonding vary greatly depending on physical and chemical factors during the bonding process. Quantitative understanding and evaluation of the surface energy of the bond are essential to improve reliability. While destructive razor blade testing has been commonly used to quantify the surface energy and interface toughness in wafer-level bonding for years, there is currently no standard quantitative method for evaluating die-level direct bonding. In this study, the displacement control of single-beam cantilever (SBC) was specially developed as a new quantitative characterization method to evaluate the surface energy at the die level. For this characterization test, we first used a 10 × 10 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die size with controlled bond surfaces, followed by a 6.3 × 10.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Cu hybrid bonding sample with an array of Cu bond pad size of 6 μm in diameter and 12 μm pitch. The pre-bonding process (wafer protection, dicing, cleaning, and surface activation), and die-level bonding methods were evaluated using this new characterization method. Process optimization resulted in die-level bonding consistency with surface energy higher than 2.0 J/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and voids-free bonding.
Molecular Alignment in Polyethylene during Cold Drawing Using In-Situ SANS and Raman Spectroscopy (2017)

Changes in the crystalline and mesoscale lamellar structure during plastic deformation of semicrystalline polymers have been extensively studied by X-ray diffraction techniques. However, direct measurements of single chain conformations during stretching have not been realized, although they are key to fully understand the structural transitions during cold drawing and their relation with the state of uniaxial stress. We report direct measurements of molecular alignment of a semicrystalline polymer during cold drawing by combining in-situ small-angle neutron scattering (SANS) and polarized Raman spectroscopy. The sample investigated is a linear low-density polyethylene (LLDPE) with density of 918 kg/m3 and melt index of 1.0 g/10 min. A multifaceted protocol consisting of hydrogen–deuterium exchange, followed by fractionation (by molecular weight, MW) and blending of selected deuterated fractions with protonated LLDPE, was used to elucidate, via SANS measurements, the response of the different fractions to uniaxial deformation. Under tensile deformation significant chain stretching occurs in the initial elastic regime. Further plastic deformation causes additional chain stretching, but to a lesser degree, that eventually plateaus in the strain hardening regime. Concurrently, the fraction of trans conformers increases linearly, as measured by in-situ Raman spectroscopy. The total orientation, quantified using an alignment factor, is lower for the lower MW fractions. We hypothesize through simple geometric arguments that this is directly related to the probability of forming intercrystal tie chains.
Magnetic guidance of ferrofluidic nanoparticles in anin vitromodel of intraocular retinal repair (2003)

Agarose gel at a concentration of 0.6% was used to simulate the vitreous body of the eye during the infusion of a ferrofluid and the subsequent magnetic concentration of it onto a surrogate retinal surface. The 10 nm Fe3O4 particles in the ferrofluid served to mimic the cobalt particles in a silicone magnetic fluid that is being developed for use as a tamponading agent in magnetic fluid therapies designed to alleviate retinal detachments and other types of retinopathy. Magnetically guided interstitial diffusion of the nanoparticles through up to 20 mm of the gel over periods of 72 h was shown to be possible, thus demonstrating that essentially all points on the retinal surface are reachable from elsewhere in the ocular interior. The nanodynamics of the magnetic and viscous forces at work on the particles during movement through the gel are discussed; in particular the diffusion speeds of the particles are estimated and compared with observations.
Molecular MR Imaging of Renal Fibrogenesis in Mice (2023)

Magnetic resonance imaging using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis.
Cadmium accrual in combined wastewater treatment-aquaculture system (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCadmium accrual in combined wastewater treatment-aquaculture systemWilliam B. Kerfoot and S. Andrew. JacobsCite this: Environ. Sci. Technol. 1976, 10, 7, 662–667Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/es60118a003https://doi.org/10.1021/es60118a003research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts