gebhart/patrepeval huggingface dataset:
Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine (2021)

The Hippo pathway is an evolutionary conserved signaling network that regulates essential processes such as organ size, cell proliferation, migration, stemness and apoptosis. Alterations in this pathway are commonly found in solid tumors and can lead to hyperproliferation, resistance to chemotherapy, compensation for mKRAS and tumor immune evasion. As the terminal effectors of the Hippo pathway, the transcriptional coactivators YAP1/TAZ and the transcription factors TEAD1-4 present exciting opportunities to pharmacologically modulate the Hippo biology in cancer settings, inflammation and regenerative medicine. This review will provide an overview of the progress and current strategies to directly and indirectly target the YAP1/TAZ protein-protein interaction (PPI) with TEAD1-4 across multiple modalities, with focus on recent small molecules able to selectively bind to TEAD, block its autopalmitoylation and inhibit YAP1/TAZ-TEAD-dependent transcription in cancer.
Assisted needle guidance using smart see-through glasses (2018)

Accurate needle placement largely depends on physicians’ visuospatial skills in CT-guided interventions. To reduce the reliance on operator experience and enhance accuracy, we developed an augmented reality system using smart seethrough glasses to facilitate and assist bedside needle angle guidance. The AR system was developed using Unity and Vuforia SDK. It displays the planned needle angle on the glasses’ see-through screens in real-time based on the glasses orientation. The displayed angle is always referenced to the CT table and independent from the physical orientation of the glasses. The see-through feature allows the operator to compare the actual needle and the planned needle angle continuously. The glasses’ orientation was tracked by its built-in gyroscope. The offset between the embedded gyroscope and the glasses’ display frame was pre-calibrated. A quick one-touch calibration method between the glasses and CT frame was implemented. Hardware accuracy and guidance accuracy was evaluated in phantom studies. In the first test, a needle was inserted in the phantom and scanned with CT. The measured angle in the CT scan was set on the glasses. We took a snapshot from the lens and compared the needle vector and guideline in the saved snapshot. The hardware accuracy was within 0.98 ± 0.85 degree. In the second test, after each insertion guided by the glasses, a CT scan was taken to validate the insertion angle error. The accuracy of the guidance was within 1.33 &plusmn; 0.73 degree. Smart glasses can provide accurate guidance for needle based interventions with minimal disturbance of the standard clinical workflow.
Isabelle Landry-Deron (éd.), La Chine des Ming et de Matteo Ricci (1552-1610). Le premier dialogue des savoirs avec l’Europe (2016)

Les 27 et 28 mai 2010 s’est tenu à Paris, au siège de l’Unesco, un colloque international consacré au quatrième centenaire de la mort, à Pékin le 11 mai 1610, de Matteo Ricci, supérieur jésuite de la première mission en Chine. On sait que l’attitude conciliante des jésuites, qu’il inaugura, envers les rites confucéens fut l’une des causes de la célèbre « Querelle des rites » qui opposa, jusqu’au milieu du xviiie siècle, la Compagnie de Jésus aux nombreux adversaires de tout accommodement avec...
Efficient Ruthenium‐Catalyzed Aerobic Oxidation of Amines Using a Biomimetic Coupled Catalytic System. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: A Stereospecific Synthesis of Tetrasubstituted Chiral Piperazines. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytic asymmetric heterogeneous aziridination of styrene using CuHY: effect of nitrene donor on enantioselectivity (2001)

The copper-catalysed aziridination of styrene with copper-exchanged zeolite Y (CuHY) and copper(II) triflate (trifluoromethanesulfonate) (Cu(OTf)2) as catalysts is described in detail. Two nitrene donors, [N-(p-tolylsulfonyl)imino)]phenyliodinane (PhINTs) and [N-(p-nitrophenylsulfonyl)imino]phenyliodinane (PhINNs) are compared. Modification of the catalyst with bis(oxazolines) affords enantioselective catalysts and a range of chiral bis(oxazolines) has been studied. The ratio of nitrene donor to styrene is shown to be an important factor controlling both the yield and ee of aziridine formed. The best results are obtained with PhINNs; ee, ≥ 90%, together with high yields (≥ 85%), can readily be achieved with this nitrene donor using acetonitrile as solvent. Addition of the nitrene donor over a period of time, rather than all at the start of the reaction, is shown to enhance the yield of the aziridine but the ee is significantly decreased for both the homogeneous and the heterogeneous catalysts. Experiments in which the breakdown products of the nitrene donor, iodobenzene and the corresponding sulfonamide, are added at the start of the reaction show that a complex interplay exists at the copper active site between the reactants, products, chiral modifier and the solvent. However, the heterogeneous catalyst, CuHY, is found to give enhanced enantioselection for a range of bis(oxazolines) compared to the homogeneous catalyst, and the effect is considered to be due to the confinement of the catalyst within the micropores of the zeolite.
SARS-CoV-2 and Assisted Reproductive Technology Practice: An Asia Pacific Initiative on Reproduction (ASPIRE) Position Paper (2020)

Background: Asia Pacific Initiative on Reproduction (ASPIRE) aims to improve knowledge and awareness of Assisted Reproductive Technology (ART) and infertility-related services, with the aim of improving the quality of patient care. Methods: A survey was developed and responded by a group of 10 ASPIRE board members to gather in-depth information about current practices, recommendations, and perceptions about SARS-CoV-2 and ART. The collected data were summarized and individual responses pooled among questions requiring voting. The overall rates were computed by response category. The group discussed the summary evidence, until a consensus was reached concerning a series of recommendation on how to make decisions concerning ART service provision during the current (and any future) pandemic. A two-tier recommendation was developed based on agreement rate and implementation priority. Tier 1 comprises recommendations in which the rate of “absolutely agree” responses were [Formula: see text]60%, whereas tier 2 refers to recommendations in which the rate of “absolutely agree” plus “agree” was &gt;60%, but the rate of “absolutely agree” was [Formula: see text]50%. Results: The survey was responded by all participants between July 24 and July 30, 2020. Nine tier 1 and five tier 2 recommendations are provided concerning prevention, testing, personal protective equipment, informed consent, and quality management. The former indicates the situations in which most individuals should receive the intervention/procedure, whereas the latter relates to those that may be suitable for individual clinics and patients. Conclusions: This document provides the ASPIRE viewpoint on better managing infertile patients seeking ART during the COVID-19 pandemic. This expert opinion guide aims to help both competent authorities and healthcare providers to deliver quality and safe ART.
Peripheral Lymphocyte Populations (1971)

Blood lymphocytes from rabbits immunized against BSA were stimulated by this antigen &lt;i&gt;in vitro&lt;/i&gt; and their response determined by the increase in uptake of &lt;sup&gt;3&lt;/sup&gt;HT. The rabbits were immunized with different doses of antigen in complete adjuvant or in saline solution and the lymphocytes, collected at intervals of 3 to 270 days were stimulated &lt;i&gt;in vitro&lt;/i&gt; by concentrations of antigen, ranging from 10&lt;sup&gt;––2&lt;/sup&gt;&lt;i&gt;&amp;#181;&lt;/i&gt;g to 2 &amp;#215; 10&lt;sup&gt;4&lt;/sup&gt;&lt;i&gt;&amp;#181;&lt;/i&gt;g/culture. Lymphocytes from rabbits immunized with 20 mg BSA in adjuvant showed a marked increase in sensitivity toward the antigen (up to 10&lt;sup&gt;5&lt;/sup&gt;-fold) when collected at intervals up to a month after immunization, while lymphocytes from rabbits immunized with 0.5 mg BSA in adjuvant reached a peak by day 16 and decreased thereafter. This increase was expressed by a decrease in the minimal dose of antigen needed to stimulate a significant response. The increase in sensitivity was faster and the levels of response were higher in rabbits immunized with 0.5 mg than with 20 mg. Lymphocytes collected at different intervals late after immunization with the above doses of antigen showed periodical changes in the levels of response with alternating high and low responses. Cells from animals immunized with 10 &lt;i&gt;&amp;#181;&lt;/i&gt;g BSA in adjuvant, on the other hand, showed low levels of response and a diminished increase in sensitivity, compared to cells from the other 2 groups. Cells from rabbits injected with BSA in saline did not react to antigen in culture. This form of antigen was found also to induce a partial unresponsiveness as shown by decreased responses after subsequent challenge with antigen in adjuvant.
Importing plants into the Netherlands: an assessment of the risk of plant parasitic nematodes and a survey on their entry with adhering soil (2016)

Few plant parasitic nematodes are currently included in the European Union (EU) regulated pest lists. However, many plant parasitic nematodes not present in the EU are known to be damaging and present a risk to Europe. Therefore a study was performed to assess the risk of importing plant parasitic nematodes with the soil attached to plants for planting, with emphasis on plants in pots. Prior to the survey, a list of harmful plant parasitic nematodes not present within Europe was prepared per continent based on a literature review. This resulted in a Risk List of 26 species. Additionally, over a 3‐year period a survey was carried out on plants for planting imported to the Netherlands with adhering soil, focusing on all plant parasitic nematodes and with special attention to the nematodes on the Risk List. A total of 258 soil samples were studied, originating from 54 different plant species and 20 different countries. Despite the small number of samples, several quarantine nematodes and species from the Risk List were detected, including new nematode–plant combinations. This survey illustrates that plants with adhering soil can be a pathway for the introduction of listed nematodes, including those from the Risk List, to the EU / EPPO region. This information might encourage a more risk‐based approach to performing import inspections.
Geographic grouping of Cryptococcus neoformans var. gattii by random amplified polymorphic DNA fingerprint patterns and ITS sequence divergence. (2000)

Eleven reference strains of Cryptococcus neoformans var. gattii were analyzed by random amplified polymorphic DNA (RAPD) patterns using three oligo primers. Three major RAPD pattern profiles (profiles I, II and III) were identified with A-1 oligo primer. Each profile was found to relate to a geographic region. Since the strains which belong to profiles I and II were mainly the isolates from America, and profile III from Asia with A-1 primer, these three profiles were assigned to the geographic grouping of America-1, America-2 and Asia, respectively. Analysis of rDNA sequences coding an internal transcribed spacer (ITS) region of C. neformans var. gattii revealed that the fungus with each RAPD profile has characteristic base sequences at the four positions (10 and 15 positions in ITS1 and 8 and 56 positions at ITS2) of the ITS regions. On the basis of the combinations of the four bases specific for the ITS regions, four ITS types, AAGG (America-1), AAAC (America-2), GGGC (Asia-1) and AGGC (Asia-2) were identified: the geographic group of Asia was further classified into two subgroups of Asia-1 and Asia-2 based on the ITS typing. Clinical isolates from Thailand (6 strains) and Brazil (7 strains) were found to belong to the geographic group of America-1 nd America-2, respectively. Five reference strains of C. neoformans var. gattii from the CBS culture collection were classified into two America-2, one Asia-1 and two Asia-2 groups. This ITS region analysis allowed us to distinguish all isolates of C. neoformans var. gattii into four geographic groups based on the ITS base sequence, and further molecular epidemiological and ecological research on this fungus is recommended.
Networks-on-Chip based Deep Neural Networks Accelerators for IoT Edge Devices (2019)

The need for performing deep neural network inferences on resource-constrained embedded devices (e.g., Internet of Things nodes) requires specialized architectures to achieve the best trade-off among performance, energy, and cost. One of the most promising architectures in this context is based on massive parallel and specialized cores interconnected by means of a Network-on-Chip (NoC). In this paper, we extensively evaluate NoC-based deep neural network accelerators by exploring the design space spanned by several architectural parameters including, network size, routing algorithm, local memory size, link width, and number of memory interfaces. We show how latency is mainly dominated by the on-chip communication whereas energy consumption is mainly accounted by memory (both on-chip and off-chip). The outcome of the analysis, thus, pushes toward a research line devoted to the optimization of the on-chip communication fabric and the memory subsystem for performance improvement and energy efficiency, respectively.
Supplementary Table 2 from Epithelial–Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression (2023)

&lt;p&gt;Supplementary Table 2. Diagnostic cutoff&lt;/p&gt;
Can cloned receptors aid drug research? (1992)

Synopsis: Over 50 different neurotransmitter and hormone receptors have been cloned, transfected and characterised. Within the pharmaceutical industry, the thrust of this research is now moving from receptor cloning to focussed application of these new tools to the task of drug development. With human receptor clones now available, it is possible to target drug design to single human proteins from the inception of a drug-design project. A critical question is whether human genes will express a human pharmacology when expressed in non-human, non-neuronal cell lines. Relevant results from studies with the human serotonin 5-HT 2 and 5-HT 1D receptors are presented, including the cloning of a rat 5-HT 1B receptor which is homologous to a human 5-HT 1D receptor gene. Another issue is the relationship between agonist and antagonist binding sites. The ability to study individual human receptors in selected cell lines which are free from interfering receptors has helped to advance our understanding of this relationship. Studies comparing agonist and antagonist binding sites of the human 5-HT 2 receptor are described. Finally, the fact that so many neurotransmitter receptors belong to the same gene superfamily, the G-protein-coupled or 7TM (7 transmembrane domain) receptor superfamily, allows us to form new insights about receptor structure and function. Examples where comparative studies of gene sequences are helping to predict pharmacological properties of drugs are described.
Alkylsulfonioarylene and Thioarylene Polymers Derived from Sulfonium Electrophiles (2003)

Abstract Superacidification of sulfoxides and sulfinates effects the electrophilic substitution reaction of the resulting hydroxysulfonium ions onto aromatic rings with the elimination of H2O at room temperature. The present account emphasizes the utility of the reaction for use as an elementary step in organic synthesis. The product, the alkyldiarylsulfonium ion, often quantitatively obtained, allows the synthesis of alkylsulfonio-bridged (λ4-alkylsulfanyliumdiyl) aromatic polymers. High molecular-weight poly(alkylsulfonioarylene) salts with a wide range of structural dimensionalities from linear to network architectures have been made accessible by the regioselective condensation of aryl sulfoxides. The polymers possess interesting properties such as good solubility in polar organic solvents and sometimes even in H2O, susceptibility to nucleophiles to provide thioarylene derivatives, photo-degradability, and electric semiconductivity, according to the dimensionality of the molecule. The synthetic chemistry of the alkylsulfonioarylene polymers as well as their possible applications in high molecular-weight poly(thioarylene) synthesis, photochemical recycling processes of an engineering plastic poly(thio-1,4-phenylene), and photo-resist technologies, are reviewed.
Recognition of Host Immune Activation by Pseudomonas aeruginosa (2005)

It is generally reasoned that lethal infections caused by opportunistic pathogens develop permissively by invading a host that is both physiologically stressed and immunologically compromised. However, an alternative hypothesis might be that opportunistic pathogens actively sense alterations in host immune function and respond by enhancing their virulence phenotype. We demonstrate that interferon-gamma binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin. These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.
New Transceiver Designs for Interleaved Frequency Division Multiple Access (2019)

This paper puts forth a class of new transceiver designs for interleaved frequency division multiple access (IFDMA) systems. These transceivers are significantly less complex than conventional IFDMA transceiver. The simple new designs are founded on a key observation that multiplexing and demultiplexing of IFDMA data streams of different sizes are coincident with the IFFTs and FFTs of different sizes embedded within the Cooley-Tukey recursive FFT decomposition scheme. For flexible resource allocation, this paper puts forth a new IFDMA resource allocation framework called Multi-IFDMA, in which a user can be allocated multiple IFDMA streams. Our new transceivers are unified designs in that they can be used in conventional IFDMA as well as multi-IFDMA systems. Two other well-known multiple-access schemes are localized FDMA (LFDMA) and orthogonal FDMA (OFDMA). In terms of flexibility in resource allocation, Multi-IFDMA, LFDMA, and OFDMA are on an equal footing. With our new transceiver designs, however, IFDMA has the following advantages (besides other known advantages not due to our new transceiver designs): 1) IFDMA/Multi-IFDMA transceivers are significantly less complex than LFDMA transceivers; in addition, IFDMA/Multi-IFDMA has better Peak-to-Average Power Ratio (PAPR) than LFDMA; 2) IFDMA/Multi-IFDMA transceivers and OFDMA transceivers are comparable in complexity; but IFDMA/Multi-IFDMA has significantly better PAPR than OFDMA.
Enhancement of Spin-Charge Conversion Efficiency for Co$_{3}$Sn$_{2}$S$_{2}$ across Transition from Paramagnetic to Ferromagnetic Phase (2022)

Co$_{3}$Sn$_{2}$S$_{2}$ (CSS) is one of the shandite compounds and becomes a magnetic Weyl semimetal candidate below the ferromagnetic phase transition temperature ($\textit{T}_\textrm{C}$). In this paper, we investigate the temperature ($\textit{T}$) dependence of conversion between charge current and spin current for the CSS thin film by measuring the spin-torque ferromagnetic resonance (ST-FMR) for the trilayer consisting of CSS / Cu / CoFeB. Above $\textit{T}_\textrm{C}$ ~ 170 K, the CSS / Cu / CoFeB trilayer exhibits the clear ST-FMR signal coming from the spin Hall effect in the paramagnetic CSS and the anisotropic magnetoresistance (AMR) of CoFeB. Below $\textit{T}_\textrm{C}$, on the other hand, it is found that the ST-FMR signal involves the dc voltages ($\textit{V}_\textrm{dc}$) not only through the AMR but also through the giant magnetoresistance (GMR). Thus, the resistance changes coming from both AMR and GMR should be taken into account to correctly understand the characteristic field angular dependence of $\textit{V}_\textrm{dc}$. The spin Hall torque generated from the ferromagnetic CSS, which possesses the same symmetry as that for spin Hall effect, dominantly acts on the magnetization of CoFeB. A definite increase in the spin-charge conversion efficiency ($ξ$) is observed at $\textit{T}$ &lt; $\textit{T}_\textrm{C}$, indicating that the phase transition to the ferromagnetic CSS promotes the highly efficient spin-charge conversion. In addition, our theoretical calculation shows the increase in spin Hall conductivity with the emergence of magnetic moment at $\textit{T}$ &lt; $\textit{T}_\textrm{C}$, which is consistent with the experimental observation.
Visual Analytics on the Financial Market: Pixel-based Analysis and Comparison of Long-Term Investments (2008)

In this paper, we describe solutions how pixel-based visualization techniques can support the decision making process for investors on the financial market. We especially focus on explorative interactive techniques where analysts try to analyze large amounts of financial data for long-term investments, and show how visualization can effectively support an investor to gain insight into large amounts of financial time series data. After presenting methods for improving the traditional performance/risk computation in order to take user-specific regions of interest into account, we present a novel visualization approach that demonstrates how changes in these regions of interest affect the ranking of assets in a long-term investment strategy.
Results of High-Spatial Resolution Mid-IR Imaging of NGC7172 (2007)

"We present results from an analysis of high-spatial resolution images of the Seyfert 2galaxy NGC 7172, as observed by T-ReCS onGemini South at 10.4 microns. We model theIR SED of this AGN using our observationsand archival data. We find that a best fitmodel describes the observed SED with areddened stellar population and 2 thermalcomponents."
An Analysis of Thermal Regulation in Hemodialysis with One and Three Compartment Models (1989)

A one compartment model of heat kinetics in hemodialysis (HD) was formulated, solved for the body surface heat transfer coefficient, and used to analyze reported clinical data. The analysis showed a linear relationship between percent change in body surface (y) and fractional dialyzer (x) heat loss, such that y = −25–44X, p< 0.001. Thus, when X = 0, surface heat loss decreases 25% and core temperature (T) rises, and μst equal 45% of heat production to stabilize core T during HD. A three compartment model predicts that skin clothing insulation will have to increase 2.5 times to avoid thermal discomfort when X = 45% of heat production. A theoretic mechanism for decreased symptomatic hypotension resulting from stabilization of core T is proposed.