gebhart/patrepeval huggingface dataset:
Photophysical Properties of an Alkyne-Bridged Bis(zinc porphyrin)−Perylene Bis(dicarboximide) Derivative (2009)

We report the synthesis, electrochemistry, and photophysical properties of a new donor-acceptor-donor molecule in which the meso carbon atoms of two zinc porphyrin (POR) units are linked through ethynylene bridges to the 1,7-positions of a central perylene-3,4:9,10-bis(dicarboximide) (PDI). In contrast to previously studied systems incorporating POR and PDI groups, this alkyne-based derivative shows evidence of through-bond electronic coupling in the ground state; the new chromophore exhibits absorption features similar to those of its constituent parts as well as lower energy features (at wavelengths up to ca. 1000 nm), presumably arising from donor-acceptor interactions. Transient absorption measurements show that excitation at several visible and near-IR wavelengths results in the formation of an excited-state species with a lifetime of 290 ps in 1% (v/v) pyridine in toluene. The absorption spectrum of this species resembles the sum of the spectra for the chemically generated radical cation and radical anion of the chromophore. The chromophore shows moderate two-photon absorption cross sections (2000-7000 GM) at photon wavelengths close to the onset of its low-energy one-photon absorption feature.
Differential image sensor with high common mode rejection (2005)

Image processing applications like tracking of moving objects typically involve the subtraction of two successive images. Doing this without the need for a large digital memory requires a sensor chip that does the subtraction in the analog domain. This paper provides insight in the critical issues of the design of such a differential image sensor. The presented sensor has two operation modes: a very low noise correlated double sampling (CDS) mode and a differential image (DI) mode. This sensor is optimized to have a high common mode rejection ratio (CMRR) which results in a small influence from the content of the image onto the differential image.
Induction of a simple morphology for highly-inflecting languages (2004)

This paper presents an algorithm for the unsupervised learning of a simple morphology of a natural language from raw text. A generative probabilistic model is applied to segment word forms into morphs. The morphs are assumed to be generated by one of three categories, namely prefix, suffix, or stem, and we make use of some observed asymmetries between these categories. The model learns a word structure, where words are allowed to consist of lengthy sequences of alternating stems and affixes, which makes the model suitable for highly-inflecting languages. The ability of the algorithm to find real morpheme boundaries is evaluated against a gold standard for both Finnish and English. In comparison with a state-of-the-art algorithm the new algorithm performs best on the Finnish data, and on roughly equal level on the English data.
The incidence of contrast medium induced acute tubular necrosis following arteriography. (1981)

Twenty-one patients slated for high-dose arteriography were studied to investigate the impact of predisposing medical conditions upon contrast medium induced acute renal failure. The study suggests that predisposing medical conditions are the most important factor determining the incidence of acute renal failure and the probability, speed, and degree of recovery of renal function. Patients with diabetes mellitus incur the highest risk of contrast medium induced acute renal failure. A dose relationship is also suggested. Contrast medium doses containing more than 100 g of iodine uniformly produced acute tubular necrosis in patients with predisposing medical conditions. Conversely, contrast medium doses containing less than 80 g of iodine produced clinically manifest acute renal failure in only one of 14 patients with predisposing medical conditions. Subclinical levels of acute renal failure were recognized in a large number of patients by routine measurement of radionuclide filtration fractions, serum creatinine levels, and urine osmolality and sodium concentration.
Mid-infrared pulse dynamics in Si nanophotonic wires near the two-photon absorption edge (2009)

We present an experimental and simulation study of the pulse dynamics in SOI nanophotonic wires at mid-infrared wavelengths beyond the telecommunications band, and illustrate the significantly reduced role of two-photon absorption.
Patterns of psoriatic arthritis in Orientals. (1997)

The commonest pattern of PsA in all ethnic groups was asymmetric polyarthritis. Ethnicity affected the development and presentation of PsA in our series: Indians with psoriasis had double the risk of developing PsA compared to Chinese with psoriasis, and lumbar spondylitis when present in Chinese subjects was asymptomatic in 45%, being detectable only on radiological examination.
Fluorescence detection of proteins in sodium dodecyl sulfate-polyacrylamide gels using environmentally benign, nonfixative, saline solution (2000)

SYPRO Tangerine stain is an environmentally benign alternative to conventional protein stains that does not require solvents such as methanol or acetic acid for effective protein visualization. Instead, proteins can be stained in a wide range of buffers, including phosphate-buffered saline or simply 150 mM NaCl using an easy, one-step procedure that does not require destaining. Stained proteins can be excited by ultraviolet light of about 300 nm or with visible light of about 490 nm. The fluorescence emission maximum of the dye is approximately 640 nm. Noncovalent binding of SYPRO Tangerine dye is mediated by sodium dodecyl sulfate (SDS) and to a lesser extent by hydrophobic amino acid residues in proteins. This is in stark contrast to acidic silver nitrate staining, which interacts predominantly with lysine residues or Coomassie Blue R, which in turn interacts primarily with arginine and lysine residues. The sensitivity of SYPRO Tangerine stain is similar to that of the SYPRO Red and SYPRO Orange stains - about 4—10 ng per protein band. This detection sensitivity is comparable to colloidal Coomassie blue staining and rapid silver staining procedures. Since proteins stained with SYPRO Tangerine dye are not fixed, they can easily be eluted from gels or utilized in zymographic assays, provided that SDS does not inactivate the protein of interest. This is demonstrated with in-gel detection of rabbit liver esterase activity using α-naphthyl acetate and Fast Blue BB dye as well as Escherichia coli β-glucuronidase activity using ELF-97 β-D-glucuronide. The dye is also suitable for staining proteins in gels prior to their transfer to membranes by electroblotting. Gentle staining conditions are expected to improve protein recovery after electroelution and to reduce the potential for artifactual protein modifications such as the alkylation of lysine and esterification of glutamate residues, which complicate interpretation of peptide fragment profiles generated by mass spectrometry.
The Spontaneous Induction of Anamnestic Antibody Synthesis in Lymph Node Cell Cultures Many Months after Primary Immunization (1973)

Abstract An in vitro model system was developed in which interactions between persisting antigen, humoral antibody, and the various lymphoid cells involved in the immune response may be analyzed. In this system IgG antibody synthesis was spontaneously induced—no extrinsic antigen required—simply by transferring lymphoid cells from a human serum albumin (HSA) immunized rabbit into cell culture. Vigorous spontaneous antibody responses were obtained in cell cultures from 1 month up to a year after immunizing with 1 mg of polymerized-HSA. Induction of the spontaneous antibody response requires a 2- to 3-day period in vitro. The quantity of antibody synthesized per day, for a 3-day period after induction, was as high as 1000 times the amount obtained on the 1st day of culture. Addition of specific antibody to cultures inhibited the inductive but not the synthetic phase of the response. Addition of microgram quantities of antigen inhibited spontaneous induction, whereas nanogram quantities inhibited in some experiments and induced additional antibody synthesis in others. Initiation of the spontaneous in vitro response was attributed to cell-associated persisting antigen, whose activity is subject to an antibody feedback mechanism.
EFFICIENT EXPRESSION OF IL12 AFTER TRANSDUCTION OF TUMOR CELLS WITH A RETROVIRAL VECTOR ENCODING BOTH SUBUNITS OF HUMAN IL12 (1993)

Journal of Immunotherapy with Emphasis on Tumor Immunology: November 1993 - Volume 14 - Issue 4 - p 364
Nickel α‐Keto‐β‐Diimine Initiators for Olefin Polymerization (2008)

Aktivierung aus der Distanz: Eine neuartige Katalysatorvorstufe, die kationisch ist und vom zusätzlichen Abzug von Elektronendichte durch Einwirkung einer Lewis-Säure auf das Ligandengerüst profitiert (siehe Bild, Ni grün, Br braun, N blau, O rot, C grau), ist in Gegenwart einer Vielzahl an Aktivatoren hoch aktiv bei der Ethylenpolymerisation und überführt α-Olefine in hochmolekulare Polymere. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
DDRE-33. MOLECULAR DIFFERENTIATION OF IMIPRIDONES ONC201 AND ONC206 (2020)

Abstract ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and agonist of ClpP in oncology. In clinical trials, the small molecule has induced durable tumor regressions and clinical benefit in H3 K27M-mutant glioma patients while being well tolerated. ONC206 is a chemical derivative of ONC201 with nanomolar anti-cancer potency. In this study, we describe receptor pharmacology, gene expression profiling, acquired resistance and biodistribution studies that suggest ONC206 exhibits distinct therapeutic properties relative to ONC201. ONC206 exhibited a nanomolar Ki for DRD2 with complete specificity across human GPCRs and complete DRD2 antagonism. Schild analyses of ONC206 in cAMP and β-Arrestin recruitment assays revealed hallmarks of non-competitive DRD2 antagonism, unlike antipsychotics but similar to ONC201. Shotgun mutagenesis across DRD2 identified 7 residues critical for ONC206-mediated antagonism at orthosteric and allosteric sites. Six residues were critical for ONC201 and ONC206, however the impact varied between the two compounds and one allosteric residue was exclusive to ONC206. Structural mapping revealed that some ONC206-critical allosteric residue interactions are located at the interface of TM-IV and –V that mediates the DRD2 homodimer interface. Gene expression profiling revealed ONC206 and ONC201 induce distinct signatures in U87 glioblastoma cells, further supporting distinct functional effects. Similarly, T98G glioblastoma cells with acquired resistance to ONC201 or ONC206 reveal partial cross resistance. Finally, rat biodistribution studies revealed nanomolar CSF concentrations that exceed therapeutic thresholds, unlike ONC201. In summary, ONC206 exhibits increased non-competitive DRD2 antagonism, nanomolar potency, distinct biodistribution, differentiated gene expression and disruption of DRD2 dimers relative to ONC201. Thus, ONC206 may be uniquely poised to address tumors that are not addressed by ONC201 or have developed acquired resistance.
Electrochemiluminescence Performances of Compositing Films of Polyluminol with Metal Ions and Its Analytical Application (2007)

In this paper, it was found that the compositing films made from polyluminol and some metal ions(such as Ni2+, Fe2+ and Co2+ ) can be easily generated on the surface of the graphite electrode by electropolymerization of luminol and these metal ions in the acidic medium. Compared to other resulting films, the compositing films made from polyluminol and Ni2+ presented the better electrochemiluminescence(ECL) analytical performance for urea based on its sensing effect for weak ECL signal of electro-oxidation polyluminol. On the basis of these results, a novel ECL method for the determination of urea in urine samples was developed, and a new method to improve the ECL analytical performances of polyluminol by compositing metal ions was also proposed. Under the optimum experimental conditions, the ECL response was linearly to the concentration of urea within the range of 2.0×10-9—1.0×10-7 g/mL with a detecting limit of 1.7×10-10 g/mL.
Supplementary Figures from Clinical Response to a Lapatinib-Based Therapy for a Li-Fraumeni Syndrome Patient with a Novel <i>HER2</i><sup>V659E</sup> Mutation (2023)

&lt;p&gt;Supplementary Figures - PDF file 585K, Supplementary Figure 1. Fluorescence in situ hybridization (FISH) of HER2. Supplementary Figure 2. EGFR and HER2 mutations identified. Supplementary Figure 3. Comparisons of allele frequencies. Supplementary Figure 4. HER2-V659E response to erlotinib and neratinib in MCF10A cells&lt;/p&gt;
High emission power and Q factor in spin torque vortex oscillator consisting of FeB free layer (2014)

Microwave oscillation properties of spin torque vortex oscillators (STVOs) consisting of an FeB vortex free layer were investigated. Because of a high MR ratio and large DC current, a high emission power up to 3.6 µW was attained in the STVO with a thin FeB free layer of 3 nm. In STOs with a thicker FeB layer, e.g., 10 nm thick, we obtained a large Q factor greater than 6400 while maintaining a large integrated emission power of 1.4 µW. Such excellent microwave performance is a breakthrough for the mutual phase locking of STVOs by electrical coupling.
Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine (2015)

Chemokines and their receptors control cell migration during development, immune system responses, and in numerous diseases, including inflammation and cancer. The structural basis of receptor:chemokine recognition has been a long-standing unanswered question due to the challenges of structure determination for membrane protein complexes. Here, we report the crystal structure of the chemokine receptor CXCR4 in complex with the viral chemokine antagonist vMIP-II at 3.1 angstrom resolution. The structure revealed a 1:1 stoichiometry and a more extensive binding interface than anticipated from the paradigmatic two-site model. The structure helped rationalize a large body of mutagenesis data and together with modeling provided insights into CXCR4 interactions with its endogenous ligand CXCL12, its ability to recognize diverse ligands, and the specificity of CC and CXC receptors for their respective chemokines.
Relationship between Aggressiveness, Self-Confidence, and Perceived Coach Support and Head Impact Exposure in Youth Football (2022)

This study evaluated head impact exposure (HIE) metrics in relation to individual-level determinants of HIE. Youth (n = 13) and high school (n = 21) football players were instrumented with the Head Impact Telemetry (HIT) system during one season. Players completed the Trait-Robustness of Self-Confidence Inventory (TROSCI), Sports Climate Questionnaire (SCQ), and Competitive Aggressiveness and Anger Scale (CAAS), measuring self-confidence, perceived coach support, and competitive aggressiveness, respectively. Relationships between HIE metrics (number of impacts, median and 95th percentile accelerations, and risk-weighted exposure (RWE)) and survey scores were evaluated using linear regression analysis. For middle school athletes, TROSCI scores were significantly negatively associated with the number of competition impacts and the mean number of impacts per player per competition. SCQ scores were significantly positively associated with median linear acceleration during practice. CAAS scores were not significantly associated with biomechanical metrics at either level of play. Perceived coach support and self-confidence might influence HIE among middle school football players. Football athletes' competitive aggressiveness may have less influence their HIE than other factors.
Materials Development in Magnetorheological Finishing: The work of Dr. Stephen Jacobs (2016)

The materials development in Magnetorheological Finishing (MRF) has been substantial over the past few decades. In this presentation, we will review the considerable contributions from Dr. Stephen Jacobs.
Nonionic Aliphatic Polycarbonate Diblock Copolymers Based on CO2, 1,2-Butylene Oxide, and mPEG: Synthesis, Micellization, and Solubilization (2019)

Carbon dioxide (CO<sub>2</sub>) is a renewable carbon source that is easily available in high purity and is utilized as a co-monomer in the direct ring-opening polymerization of epoxides to obtain aliphatic polycarbonates. In this work, degradable aliphatic polycarbonate diblock copolymers (mPEG- b-PBC) are synthesized via catalytic copolymerization of CO<sub>2</sub> and 1,2-butylene oxide, starting from monomethoxy poly(ethylene glycol) (mPEG) as a chain transfer reagent. The polymerization proceeds at low temperatures and high CO<sub>2</sub> pressure, utilizing the established binary catalytic system ( R, R)-Co(salen)Cl/[PPN]Cl. Amphiphilic nonionic diblock copolymers with varying PBC block lengths and hydrophilic-lipophilic balance values between 9 and 16 are synthesized. The polymers are characterized via NMR and Fourier transform infrared spectroscopies as well as size exclusion chromatography, exhibiting molecular weights ranging from 2400 to 4100 g mol<sup>-1</sup> with narrow dispersities ( Đ = M<sub>w</sub>/ M<sub>n</sub>) from 1.07 to 1.18. Furthermore, the thermal properties, i.e., T<sub>g</sub>, T<sub>m</sub>, and T<sub>d</sub>, are determined. Surface tension measurements prove that the amphiphilic polymers form micelles above the critical micelle concentration, whereas small-angle neutron scattering shows that they are of nearly spherical shape. Adding small amounts of the synthesized mPEG- b-PBC polymers to different microemulsion systems, we found that the polymers were able to strongly increase the efficiency of medium-chain surfactants to solubilize polar oils.
CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity (2022)

In many solid cancers, tumor-associated macrophages (TAM) represent the predominant myeloid cell population. Antigen (Ag) cross-presentation leading to tumor Ag-directed cytotoxic CD8+ T cell responses is crucial for antitumor immunity. However, the role of recruited monocyte-derived macrophages, including TAM, as potential cross-presenting cells is not well understood. Here, we show that primary human as well as mouse CD206+ macrophages are effective in functional cross-presentation of soluble self-Ag and non-self-Ag, including tumor-associated Ag (TAA), as well as viral Ag. To confirm the presence of cross-presenting TAM in vivo, we performed phenotypic and functional analysis of TAM from B16-F10 and CT26 syngeneic tumor models and have identified CD11b+F4/80hiCD206+ TAM to effectively cross-present TAA. We show that CD11b+CD206+ TAM represent the dominant tumor-infiltrating myeloid cell population, expressing a unique cell surface repertoire, promoting Ag cross-presentation and Ag-specific CD8+ T cell activation comparable with cross-presenting CLEC9A+ DCs (cDC1). The presence of cross-presenting CD206+ TAM is associated with reduced tumor burden in mouse syngeneic tumor models and with improved overall survival in cutaneous melanoma patients. Therefore, the demonstration of effective Ag cross-presentation capabilities of CD206+ TAM, including their clinical relevance, expands our understanding of TAM phenotypic diversity and functional versatility.
Meningococcal polysaccharide-protein conjugate vaccines (1997)

oligosaccharide-and polysaccharide-protein conjugate vaccines are under investigation in humans for prevention of disease caused by serogroup A and C organisms.
Protecting the NOEKEON Cipher against SCARE Attacks in FPGAs by Using Dynamic Implementations (2009)

Protecting an implementation against side channel analysis for reverse engineering (SCARE) attacks is a great challenge and we address this challenge by presenting a first proof of concept. White-box cryptography has been developed to protect programs against an adversary who has full access to their software implementation. It has also been suggested as a countermeasure against side channel attacks and we examine here these techniques in the wider perspective of SCARE. We consider that the adversary has only access to the cryptographic device through its side channels and his goal is to recover the specifications of the algorithm. In this work, we focus on FPGA (field-programmable gate array) technologies and examine how to thwart SCARE attacks by implementing a block cipher following white-box techniques. The proposed principle is based on changing dynamically the implementations. It is illustrated by an example on the Noekeon cipher and feasibility in different FPGAs is studied.
Outcomes and Practical Information for Patients Choosing Nonoperative Treatment for Distal Biceps Ruptures (2010)

The goal of this study was to evaluate the outcomes of patients selecting nonoperative treatment for distal biceps tendon ruptures to provide information to patients and caregivers to consider in decision making. Five men conservatively treated for distal biceps tendon rupture between November 2002 and December 2006 were compared to 5 age-matched controls treated operatively. Outcomes at 4.5 years included supination strength, range of motion, and American Shoulder and Elbow Surgeons (ASES) score. Two groups of 9 normal volunteers--1 young group averaging 30.7 years and 1 older group averaging 48.8 years--served as controls. In nonoperative patients, elbow supination strength in the injured arm was 4.14 Nm (SD 0.94) and in the uninjured arm was 4.91 Nm (SD 0.65). In operative patients, supination strength was 4.25+/-1.08 Nm in the operatively repaired arm and 5.74+/-1.27 Nm in the uninjured arm. Age-matched normal patients had supination strength of 5.78+/-1.46 Nm in the dominant arm and 5.59+/-1.32 Nm in the nondominant arm. The ASES score averaged 89.57, with 3 patients reporting pain, compared to a score of 87.5 in the operative patients. Patients choosing conservative treatment for distal biceps ruptures have residual pain and weakness approximately double that seen between normal dominant and non-dominant extremities.
8.1 μ m-emitting InP-based quantum cascade laser grown on Si by metalorganic chemical vapor deposition (2023)

This study presents the growth and characterization of an 8.1 μm-emitting, InGaAs/AlInAs/InP-based quantum cascade laser (QCL) formed on an InP-on-Si composite template by metalorganic chemical vapor deposition (MOCVD). First, for the composite-template formation, a GaAs buffer layer was grown by solid-source molecular-beam epitaxy on a commercial (001) GaP/Si substrate, thus forming a GaAs/GaP/Si template. Next, an InP metamorphic buffer layer (MBL) structure was grown atop the GaAs/GaP/Si template by MOCVD, followed by the MOCVD growth of the full QCL structure. The top-surface morphology of the GaAs/GaP/Si template before and after the InP MBL growth was assessed via atomic force microscopy, over a 100 μm2 area, and no antiphase domains were found. The average threading dislocation density (TDD) for the GaAs/GaP/Si template was found to be ∼1 × 109 cm−2, with a slightly lower defect density of ∼7.9 × 108 cm−2 after the InP MBL growth. The lasing performance of the QCL structure grown on Si was compared to that of its counterpart grown on InP native substrate and found to be quite similar. That is, the threshold-current density of the QCL on Si, for deep-etched ridge-guide devices with uncoated facets, is somewhat lower than that for its counterpart on native InP substrate, 1.50 vs 1.92 kA/cm2, while the maximum output power per facet is 1.64 vs 1.47 W. These results further demonstrate the resilience of QCLs to relatively high residual TDD values.