gebhart/patrepeval huggingface dataset:
Karyotype-specific microRNA signature in chronic lymphocytic leukemia (2009)

Abstract Chromosomal abnormalities, immunoglobulin heavy chain variable–region (IGHV) gene mutation status, and ζ-associated protein 70 (ZAP-70) expression levels have independent prognostic relevance in chronic lymphocytic leukemia (CLL); however, their concordance is variable. Because deregulation of microRNAs has been linked to disease initiation and progression in CLL, we studied the value of the microRNAs as a signature for CLL patients with specific chromosomal abnormalities. We identified 32 microRNAs able to discriminate the 11q deletion, 17p deletion, trisomy 12, 13q deletion, and normal karyotype cytogenetic subgroups. The expression values of 9 among the 32 microRNAs (miR-151-3p, miR-34a, miR-29c, miR-29b, miR-155, miR-148a, miR-146a, miR-146b5p, and miR-640) were correlated with gene expression data from the same samples to assess their biologic impact on CLL. In this study we also found that IGHV unmutated, high expression of ZAP-70 protein, and low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion, whereas in those harboring trisomy 12 only high expression of the miR-181a, among the analyzed parameters, suggested more aggressive disease. Thus, the use of the microRNA-based classifications may yield clinically useful biomarkers of tumor behavior in CLL.
High spatial resolution fiber optical sensors for simultaneous temperature and chemical sensing for energy industries (2017)

This paper demonstrates optical fibers as high-temperature sensor platforms. Through engineering and onfiber integration of functional metal oxide sensory materials, we report the development of an integrated sensor solution to perform temperature and chemical measurements for high-temperature energy applications. Using the Rayleigh optical frequency domain reflectometry (OFDR) distributed sensing scheme, the temperature and hydrogen concentration were measured along the fiber. To overcome the weak Rayleighbackscattering intensity exhibited by conventional optical fibers, an ultrafast laser was used to enhance the Rayleigh scattering by a direct laser writing method. Using the Rayleigh-enhanced fiber as sensor platform, both temperature and hydrogen reaction were monitored at high temperature up to 750&deg;C with 4-mm spatial resolution.
Cost analysis and complication rate comparing open, mini-open, and all arthroscopic rotator cuff repair (2021)

In this investigation, the median standardized costs for RCR inclusive of 60-day workup and 90-day postoperative care were $10,704.15, $11,418.25, and $11,691.65 for oRCR, CRCR (average added cost $714.10), and ARCR (added cost $987.50), respectively. The group complication, reoperation, and readmission rate were 0.5%, 0.5%, and 1.8% with no significant differences between the varying techniques, respectively. This retrospective cost analysis and complication profile may serve as a useful reference as surgeons consider engaging in bundled payment for RCR. As value based initiatives continue to progress, implant cost may serve as an actionable area for cost reduction.
Table S4 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Table 4: Summary statistics for cellularity between 4-chemokinehi and 4-chemokinelo groups in liver metastases&lt;/p&gt;
Vessel Tracking: Prospective Adjustment of Section-selective MR Angiographic Locations for Improved Coronary Artery Visualization over the Cardiac Cycle (2000)

To follow the motion of the coronary artery in magnetic resonance angiography, the authors evaluated vessel tracking, a method for prospective adjustment of the section location as a function of the delay from the cardiac trigger. In 10 volunteers and four patients, this method allowed the vessel to be maintained in the plane of acquisition throughout the cardiac cycle. With a single-phase multisection sequence, vessel-tracking acquisitions had an efficiency of 0.68 +/- 0.04 for both the right and left coronary arteries compared with 0.19 +/- 0.03 for a non-vessel-tracking acquisition (P < .001).
007, con licencia para regresar: El norteamericano Jeffery Deaver pone al día al famoso agente secreto en "Carta blanca" (Umbriel) (2011)

Through sharing the process that we undertook, we aim to support other abdominal wall units who wish to develop and improve their own consent process.
Suppressed UDP-galactose: Ceramide galactosyltransferase and myelin protein mRNA in twitcher mouse brain (1998)

The developmental changes in expression of steady-state mRNA that encode proteins that are important for myelination (myelin basic protein, myelin-associated glycoprotein, proteolipid protein, UDP-galactose: ceramide galactosyltransferase) and glial fibrillary acidic protein were investigated in the brain of the twitcher mouse, a model of human globoid cell leukodystrophy. This disease is caused by a mutation in the gene encoding the lysosomal enzyme, galactosylceramidase, which catalyzes the degradation of the myelin lipid galactosylceramide. Before postnatal day (PND) 20, the levels of myelin protein mRNA were similar in twitcher and normal mice. With progression of demyelination after PND 25-30, myelin protein mRNA levels gradually decreased. The period of maximum expression of the myelin protein genes in twitcher mice was, however, similar to that of normal control mice. mRNA levels for the gene that encodes the enzyme UDP-galactose:ceramide galactosyltransferase which is responsible for catalyzing the final step in galactosylceramide synthesis, was exceptionally down-regulated from the early stages of the disease. The increase of glial fibrillary acidic protein (GFAP) mRNA levels preceded morphological evidence of demyelination.
Chemical and structural relationships among the oligomeric compounds MFe(CO)4 (M = zinc, cadmium, mercury), iron lead tetracarbonyl, cobalt silver tetracarbonyl, and their Lewis base adducts (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical and structural relationships among the oligomeric compounds MFe(CO)4 (M = zinc, cadmium, mercury), iron lead tetracarbonyl, cobalt silver tetracarbonyl, and their Lewis base adductsRichard D. Ernst and Tobin J. MarksCite this: Inorg. Chem. 1978, 17, 6, 1477–1484Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ic50184a017https://doi.org/10.1021/ic50184a017research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Book and software reviews (1996)

S. J. Haswell, M. Cooke, M. Cresser, P. Towlson, R. M. Harrison, K. D. Bartle, A. D. Walmsley, R. B. Taylor, M. Cave and M. R. Smyth, Analyst, 1996, 121, 73N DOI: 10.1039/AN996210073N
Co-evolutionary Modular Neural Networks for Automatic Problem Decomposition (2005)

Decomposing a complex computational problem into sub-problems, which are computationally simpler to solve individually and which can be combined to produce a solution to the full problem, can efficiently lead to compact and general solutions. Modular neural networks represent one of the ways in which this divide-and-conquer strategy can be implemented. Here we present a co-evolutionary model which is used to design and optimize modular neural networks with task-specific modules. The model consists of two populations. The first population consists of a pool of modules and the second population synthesizes complete systems by drawing elements from the pool of modules. Modules represent a part of the solution, which co-operates with others in the module population to form a complete solution. With the help of two artificial supervised learning tasks created by mixing two sub-tasks we demonstrate that if a particular task decomposition is better in terms of performance on the overall task, it can be evolved using this co-evolutionary model.
Time Series Optimization-Based Characteristic Curve Calculation for Local Reactive Power Control Using <em>pandapower</em>-<em>PowerModels</em> Interface (2023)

The local reactive power control in distribution grids with a high penetration of distributed energy resources (DERs) is essential in future power system operation. Appropriate control characteristic curves for DERs support stable and efficient distribution grid operation. However, the current practice is to configure local controllers collectively with constant characteristic curves that may not be efficient for volatile grid conditions or the desired targets of grid operators. To address this issue, this paper proposes a time series optimization-based method to calculate control parameters, which enables each DER to be independently controlled by an exclusive characteristic curve for optimizing its reactive power provision. To realize time series optimizations, the open-source tools pandapower and PowerModels are interconnected functionally. Based on the optimization results, Q(V)- and Q(P)-characteristic curves can be individually calculated using the linear decision tree regression to support voltage stability and provide reactive power flexibility and potentially reduce grid losses and component loadings. In this paper, the newly calculated characteristic curves are applied in two representative case studies, and the results demonstrate that the proposed method outperforms the reference ones suggested by grid codes.
Micropower Pulse Frequency Modulator for Use in an Optically Isolated Catheter System (1982)

A micropower pulse frequency modulator (PFM) has been developed for implementing an opticaily isolated system capable of making sensor voltage measurements. The PFM circuit is powered with an array of solar cells which converts light energy into electrical energy. An input port receives the sensor voltage. The PFM signal generated by the circuit drives an infrared emitting diode which provides the frequency-modulated output signal. The PFM circuit can accept sensor output voltages in the range ±500 mV and has a minimum bandwidth of 500Hz.
Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. (1995)

Signal transduction by tyrosine kinase growth factor receptors involves the activation of multiple intracellular signaling pathways. In many cases, this occurs via direct binding of a downstream signaling protein to the phosphorylated receptor via src-homology 2 domains on the signaling protein. In this review of the hepatocyte growth factor receptor c-met, the ability of the amino acid sequence of the receptor to dictate which signaling proteins are activated is described, with particular emphasis on association with the phosphatidylinositol 3-kinase. Recent developments that provide new understanding of the mechanisms of downstream signal transduction by the phosphatidylinositol 3-kinase are discussed, including how these might be involved in the mitogenic, motogenic, and tubulogenic effects of hepatocyte growth factor on renal epithelial cells.
Cavity QED with N-V centers in diamond (2006)

Nitrogen-vacancy centers in diamond can provide a Lambda-type energy level structure with long-lived ground-state spin coherence. This talk reports progress toward demonstration of EIT in a single center coupled to an optical cavity.
(N-Benzyl-bis-N′,N″-salicylidene)-cis-1,3,5-triaminocyclohexane copper(ii): a novel catalyst for the aerobic oxidation of benzyl alcohol (2005)

Reaction of Cu(BF(4))(2).6H(2)O with the N(3)O(2) donor ligand H(2)L (where H(2)L = N-benzyl-N',N''-di-tert-butyl-disalicyl-triaminocyclohexane) results in the formation of a novel Cu(II)L complex, 1. X-Ray crystallography of it shows the Cu(II) centre coordinated by two phenolate oxygens and two imine nitrogens in a distorted square plane with an elongated bond to the amine nitrogen (2.512 A) in the axial position. EPR spectroscopy gives g values of g(1) = 2.277, g(2) = 2.100, g(3) = 2.025, and A(1) = 15.6 mT which are consistent with the distorted square pyramidal coordination environment determined from the X-ray structure. UV/visible and electrochemical analysis of shows that it undergoes two reversible processes assigned to the successive oxidation of the phenolate oxygens to phenoxyl radicals, the first at E((1/2)) = 0.89 V (DeltaE = 81 mV, vs. Ag/AgCl) and the second at E((1/2)) = 1.13V (DeltaE = 84 mV, vs. Ag/AgCl). Chemical oxidation results in the formation of a species, assigned as [1](+)(.) which is EPR silent due to antiferromagnetic coupling between the Cu(II) centre and the bound phenoxyl radical. The oxidised species catalyses the oxidation of benzyl alcohol to benzaldehyde.
IV.C.3 Hydrogen Trapping through Designer Hydrogen Spillover Molecules with Reversible Temperature and Pressure-Induced Switching (2013)

Synthesize designer microporous metal-organic • frameworks (MMOFs) mixed with catalysts to enable H-spillover for H2 storage at 300 K to 400 K and moderate pressures. Adapted volumetric measurements to enable rapid • screening tests (RSTs) at high-pressure, towards Go/No-Go decision point. Validate RSTs against published activated carbon and spillover materials at P<80 bar and 298 K. Use RST to down-select MMOFs and determine • effect of structure and surface chemistry. Explore methods for pressure-induced hydrogen/gas • trapping.
Nucleophilic Addition to Electron‐Rich Heteroaromatics: Dearomatizing Anionic Cyclizations of Pyrrolecarboxamides. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Surgical management of aortic dissection in patients with the Marfan syndrome. (1994)

Despite satisfactory early results, the long-term survival of patients with the Marfan syndrome was suboptimal (albeit similar to those without the Marfan syndrome). Future progress will pivot on reducing the incidence of aortic dissection in these patients with medical therapy and/or earlier surgical intervention and enhanced postoperative serial imaging surveillance of the entire aorta.
Applications Of Fourier Transform Raman Spectroscopy To Polymeric Systems (1990)

Raman spectroscopy is an extremely sensitive technique used to characterize structure and local order in polymeric systems. Unfortunately it has never attained the routine analytical utility which other techniques such as infrared spectroscopy have due to the presence, in most long chain polymers, of trace amounts of impurities (chemical initiators, catalyst residues, stabilizers, etc.). These impurities give rise to strong fluorescence in the visible which interferes with the recording of a Raman spectrum in this region. Recently, however, with the advent of cw Nd:YAG lasers and low temperature InGaAs detectors, Raman spectroscopy in the near infrared has become possible. Near infrared photons do not give rise to fluorescence and hence Raman scattering from polymeric materials containing chromophores either as an inherent part of their molecular structure or as an impurity can be routinely obtained. The spectral distribution of the scattered light is obtained using a commercially available Fourier transform IR (FTIR) spectrometer thus giving name to the technique. Since the inception of this technique in 1985, Fourier transform Raman spectroscopy has been utilized to investigate the structure of biomolecules, the nature of order-disorder transitions in polysilanes and the orientation of side chain chromophores in carbon backbone polymers useful for nonlinear optical applications. Several examples will be used to explicitly illustrate the utility of this new spectroscopic technique.
Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line. (1981)

Abstract We have attempted to determine the requirements for slg and T cell factors in the polyclonal activation of murine 6 lymphocytes. Highly enriched normal (neonatal or adult) or neoplastic B cells were cultured with T cell supernatants in the absence or presence of Sepharosecoupled anti-µ or anti-δ and assayed for polyclonal IgM secretion. The T cell supernatants were derived from Con A pulsed normal spleen cells, the C.C3.11.75 T cell line stimulated with antigen, or the B151K12 hybridoma (not pulsed with Con A). Unlike the spleen cell supernatants, the C.C3.11.75 and B151K12 supernatants lack Interleukin-1 (IL-1) and lnterleukin-2 (IL-2); all 3 supernatants contain T cell-replacing factor (TRF). We have confirmed previous data which demonstrated that a) anti-Ig induces proliferation of mature B cells, and b) terminal differentiation to IgM secretion requires the presence of both anti-Ig and supernatant from Con A-pulsed spleen cells (CAS). In addition, we have shown that immature B cells, which do not proliferate in response to anti-Ig, can be induced to secrete IgM by anti-Ig plus CAS. In contrast to supernatants from Con A-pulsed spleen cells, supernatants from the C.C3.11.75 and B151K12 cell lines alone induced polyclonal IgM secretion by all populations of B cells tested; this was not accompanied by detectable proliferation. Furthermore, the polyclonal responses induced by the supernatants from the line and the hybridoma were not enhanced by anti-Ig. These results suggest that there are at least 2 pathways for T cell-induced B cell differentiation in vitro and that these pathways may involve different subpopulations of B cells. The 1st pathway requires 2 signals: 1 is provided by soluble macrophage or T cell factor(s) and the other is provided by cross-linking of slg. The 2nd pathway involves differentiation of some B cells in response to T cell help alone. These pathways can be distinguished by the source of the T cell supernatants.
Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers (2013)

The development of new therapeutics for the treatment of neurodegenerative pathophysiologies currently stands at a crossroads. This presents an opportunity to transition future drug discovery efforts to target disease modification, an area in which much still remains unknown. In this Perspective we examine recent progress in the areas of neurodegenerative drug discovery, focusing on some of the most common targets and mechanisms: N-methyl-d-aspartic acid (NMDA) receptors, voltage gated calcium channels (VGCCs), neuronal nitric oxide synthase (nNOS), oxidative stress from reactive oxygen species, and protein aggregation. These represent the key players identified in neurodegeneration and are part of a complex, intertwined signaling cascade. The synergistic delivery of two or more compounds directed against these targets, along with the design of small molecules with multiple modes of action, should be explored in pursuit of more effective clinical treatments for neurodegenerative diseases.
Gigahertz speed operation of compact, non-resonant epsilon-near-zero silicon photonic modulators (2018)

We describe the design, fabrication, and performance of a fast, compact electroabsorption modulator based on transparent conducting oxides. The modulator works by using bias voltage to increase carrier density in the conducting oxide which changes the permittivity and, hence, optical attenuation by almost 10 dB. Under bias, light is tightly confined to the conducting oxide layer through non-resonant epsilon-near-zero (ENZ) effects which enable modulation over a broad range of wavelengths in the telecommunications band. Our approach features simple integration with passive silicon waveguides, the use of stable inorganic materials, and the ability to modulate both transverse electric (TE) and magnetic (TM) polarizations with the same device design. Using a 4 micrometer long modulator and a drive voltage of 2 Vpp, we demonstrate digital modulation at rates of 2.5 Gb/s. This work verifies that high-speed ENZ devices can be created using conducting oxide materials and paves the way for additional technology development that could have broad impact on future optical communications systems.
Space-Frequency Coding for Dual Polarized Hybrid Mobile Satellite Systems (2012)

An increasing number of hybrid mobile systems comprising a satellite and a terrestrial component are becoming standardized and realized. The next generation of these systems will employ higher dimensions adopting multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) techniques. In this work, we build upon recent studies of dual polarization MIMO for each component and propose the use of full-rate full-diversity (FRFD) codes adopting a space-frequency paradigm. We also propose a scheme taking advantage of the separation between the subcarriers to enhance the coding gain. By critically assessing the different options for the 4 transmit, 2 receive hybrid scenario taking into account system and channel particularities, we demonstrate that the proposed scheme is a solution for enhancing the performance of next generation hybrid mobile satellite systems.
Radically Coarse-Grained Approach to the Modeling of Chemical Degradation in Fuel Cell Ionomers (2014)

We present a kinetic model of chemical degradation in perfluorosulfonic acid ionomer membranes. It accounts for pathways of radical formation along with mechanisms of ionomer degradation through radical attack. Simplifications in the set of model equations leads to analytical expressions for the concentration of hydroxyl radicals as a function of initial concentrations of iron ions and hydrogen peroxide. The coarse-grained ionomer degradation model distinguishes units that correspond to ionomer head groups, trunk segments of ionomer side chains, and backbone segments between two side chains. A set of differential equations is formulated to describe changes in concentrations of these units. The model is used to study the impact of different degradation mechanisms and ionomer chemistries on fluorine loss and change in ion exchange capacity. Comparison of the model with experimental degradation data for Nafion and Aquivion membranes allows rate constants of degradation processes to be determined. Results of these analyses are discussed in view of strategies to mitigate chemical degradation of ionomer membranes.
Nonlinear Absorption in Quantum Confined Semiconductors (2012)

We show how the semiconductor band structure influences the size dependence trends of two-photon absorption in quantum dots. We demonstrate, via two-photon spectroscopy, that parity symmetry does not hold in small lead-chalcogenides quantum-dots