gebhart/patrepeval huggingface dataset:
Novel insights on association and reactivity of Bispectral Index, frontal electromyogram, and autonomic responses in nociception- sedation monitoring of critical care patients (2022)

Abstract Background: Assessing nociception and sedation in mechanically ventilated patients in the ICU is challenging, with few reliable methods available for continuous monitoring. Measurable cardiovascular and neurophysiological variables, such as frontal EEG, frontal EMG, and blood pressure, are potential methods for sedation and nociception monitoring. The hypothesis of this explorative study is that the aforementioned variables predict the level of sedation, as described by the Richmond Agitation-Sedation score (RASS). Methods: Thirty adult postoperative ICU patients on mechanical ventilation and receiving intravenous sedation, excluding patients with primary neurological disorders, head injury, or need for continuous neuromuscular blockage. Bispectral Index (BIS), EMG power (EMG), EMG-derived Responsiveness Index (RI), and averaged blood pressure variability (ARV) were tested against RASS measurements. The aforementioned variables together with blood pressure and Surgical Pleth Index (SPI) were explored before and after painful stimuli (for example bronchoscopy, or pleural puncture) at varying RASS levels, to test variable responsiveness. Results: BIS, EMG, and RI predicted RASS levels with a prediction probability (P K ) of 0.776 for BIS, 0.761 for EMG, and 0.763 for RI. In addition, BIS, EMG, and ARV demonstrated responsiveness to painful stimuli during deep sedation (RASS score ≤-3). Conclusion: Variables derived from EEG and EMG are associated with sedation levels, as described by the RASS score. Furthermore, these variables, along with ARV, react with consistency to painful stimuli during deep sedation (RASS -5 to -3), offering novel tools for nociception-sedation monitoring of mechanically ventilated ICU patients requiring deep sedation.
Personalization of Mobile Multimedia Broadcasting (2008)

This special issue is devoted to a well-focused subject: personalization of mobile multimedia broadcasting. Nevertheless, the topics of the papers published here demonstrate an amazing diversity. This phenomenon suggests that our subject is both highly relevant and experiencing a period of rapid change. Until recently broadcasting has been a wellestablished, relatively stable technology. However, new usage scenarios, mobile consumers together with mobile devices, and the desire for personalized content are providing new challenges. We currently have many more questions than answers. We are confronted with a range of subtly different techniques, such as digital TV, IPTV, video-on-demand, WebTV, live casts, mobile TV, peer-to-peer TV, and video-portals, which use different encoding/decoding standards, transmission protocols, streaming methods, quality-of-service levels, and interactivity features. In addition, they often require different bandwidth and different infrastructure. In view of this diversity, it is sensible to take a fresh look at the basic concepts. The rest of this special issue is dedicated to presenting a nice selection of timely, ongoing research. Therefore, this editorial introduction starts (Sections 2–4) with a contextual overview authored by Laszlo Boszormenyi. This overview concentrates on “the past and the future of this topic”—leaving the present, together with all of its unsolved questions, to be the subject of the rest of the papers. An overview of the different contributions in this special issue closes this editorial introduction in Section 5. At first glance, broadcasting and personalization seem to contradict one another. The idea of broadcasting is to transmit a message from an authority to everybody; the idea of personalization is to exchange messages between individuals. Broadcasting offers a high degree of sharing and a low level of privacy. Personalization, on the other hand, usually offers the opposite: privacy increases, but sharing decreases. There are a number of basic issues requiring very different, often contradictory treatment, and strategies. May be the most important of these issues are (1) authenticity and popularity, (2) personalization and privacy, (3) sharing, (4) interactivity, and (5) rights management.
Mixed-clock issue queue design for energy aware, high-performance cores (2004)

Globally-asynchronous, locally-synchronous (GALS) design style has started to gain interest recently as a possible solution to the increased design complexity, power and thermal costs, as well as an enabler for allowing fine grain speed and voltage management. Due to its inherent complexity, a possible driver application for such a design style is the case of superscalar, out-of-order processors. We propose a novel mixed-clock issue queue design, and compares and contrasts this new implementation with existing synchronous or mixed-clock versions of issue queues, used in standalone mode or in conjunction with mixed-clock FIFO (first-in, first-out) buffers for inter-domain synchronization. Both transistor level, SPICE simulation, as well as cycle-accurate, microarchitectural analysis, show that cores using mixed-clock issue queues are able to provide better energy-performance operating points when compared to their synchronous or asynchronous FIFO-based counterparts.
LC-MS/MS Validation for Drug of Abuse Testing Utilizing a Split Sample Oral Fluid Collection System. (2020)

&lt;p&gt;The Substance Abuse and Mental Health Services Administration (SAMHSA) recently authorized oral fluid (OF) as a preferable biofluid for drugs of abuse (DOA) screening compared to urine, and they required that each screening method be confirmed by a laboratory test. We developed a DOA mass spectrometry (MS) assay optimized for undiluted OF as a matching confirmatory test for the EZ-Saliva point of care (POC), split sample, rapid visual test. Using a double isotope ratio standardization, we achieved a limit of detection of &lt;0.3 ng/mL for seven DOAs, with high precision in undiluted patient OF (CV&lt;7.2%), linearity of R&lt;sup&gt;2&lt;/sup&gt; = 0.99, lack of interference (&lt;1.0%) by a panel of interfering compounds at 1000-fold excess, and a dynamic range of 0-850 ng/mL, from a consented population of N=84 self-reported THC users using the collection device (device yield &gt;90%). Stability from degradation exceeded 72 hours. The lateral flow immunoassay strips of the POC exhibited a dose-dependent response, with a 90% sensitivity and 100% specificity for N=22 self-reported, THC patient OF, digitized for quantitation. We conclude that the split sample POC device in combination with the MS assay meets the SAMHSA stated requirements for a POC test with a laboratory confirmation. Split sample collection has significant advantages because it minimizes potential error created by taking a separate OF sample for laboratory confirmation. We recommend scaling to a larger validation study set and quantification of user OF THC levels that correlate with driver impairment levels. &lt;/p&gt;
Heavy-chain-only antibodies for protection against MERS-CoV (2019)

Trabajo presentado en el European Congress of Virology, celebrado en Rotterdam (Países Bajos), del 28 de abril al 1 de mayo de 2019
Food Image Recognition Using Very Deep Convolutional Networks (2016)

We evaluated the effectiveness in classifying food images of a deep-learning approach based on the specifications of Google's image recognition architecture Inception. The architecture is a deep convolutional neural network (DCNN) having a depth of 54 layers. In this study, we fine-tuned this architecture for classifying food images from three well-known food image datasets: ETH Food-101, UEC FOOD 100, and UEC FOOD 256. On these datasets we achieved, respectively, 88.28%, 81.45%, and 76.17% as top-1 accuracy and 96.88%, 97.27%, and 92.58% as top-5 accuracy. To the best of our knowledge, these results significantly improve the best published results obtained on the same datasets, while requiring less computation power, since the number of parameters and the computational complexity are much smaller than the competitors?. Because of this, even if it is still rather large, the deep network based on this architecture appears to be at least closer to the requirements for mobile systems.
Meningitis after cochlear implantation (2007)

The risk is low, and preventive measures can reduce this further
Production de froid solaire : Développement de procédés thermochimiques pour la production de froid solaire par capteurs solaires plans (2006)

International audience
Supplementary Materials, Methods, Figures and Table legends from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside (2023)

&lt;p&gt;Supplementary Materials, Methods, Figures and Table legends - PDF file 87K, Supplementary file giving details of supplementary materials and methods, figure legends and table legends&lt;/p&gt;
Slower Recovery After Two-Incision Than Mini-Posterior-Incision Total Hip Arthroplasty (2009)

Our hypothesis that the two-incision technique for total hip arthroplasty would substantially improve the short-term recovery after total hip arthroplasty compared with the mini-posterior-incision technique was not proved; instead, the patients managed with the mini-posterior-incision technique had the quicker recovery.
The response effect of pheochromocytoma (PC12) cell lines to oxidized multi-walled carbon nanotubes (<i>o</i>-MWCMTs) (2014)

In conclusion, the o-MWCNTs did not affect the growth rate and viability of the PC12 cells due to lack of considerable toxicity in the cells during the observed time period but further investigations are required to determine cell recovery mechanism.
Rapid Ether and Alcohol C–O Bond Hydrogenolysis Catalyzed by Tandem High-Valent Metal Triflate + Supported Pd Catalysts (2013)

The thermodynamically leveraged conversion of ethers and alcohols to saturated hydrocarbons is achieved efficiently with low loadings of homogeneous M(OTf)n + heterogeneous Pd tandem catalysts (M = transition metal; OTf = triflate; n = 4). For example, Hf(OTf)4 mediates rapid endothermic ether ⇌ alcohol and alcohol ⇌ alkene equilibria, while Pd/C catalyzes the subsequent, exothermic alkene hydrogenation. The relative C-O cleavage rates scale as 3° > 2° > 1°. The reaction scope extends to efficient conversion of biomass-derived ethers, such as THF derivatives, to the corresponding alkanes.
Low Band Gap Benzimidazole COF Supported Ni3N as Highly Active OER Catalyst (2016)

Covalent organic frameworks (COFs) have structures and morphologies closely resembling graphenes, whose modular construction permits atomic‐level manipulations. This, combined with their porous structure, makes them excellent catalyst supports. Here, the high electrocatalytic activity of a composite, formed by supporting Ni 3 N nanoparticles on a benzimidazole COF, for oxygen evolution reaction is shown. The composite oxidizes alkaline water with a near‐record low overpotential of 230 mV @ 10 mA cm −2 ( η 10 ). This high activity is attributed to the ability of the COF to confine the Ni 3 N nanoparticles to size regimes otherwise difficult to obtain and to its low band gap character (1.49 eV) arising from the synergy between the conducting Ni 3 N nanoparticles and the π‐conjugated COF. The COF itself, as a metal‐free self‐standing framework, has an oxygen evolution reaction activity with η 10 of 400 mV. The periodic structure of the COF makes it serve as a matrix to disperse the catalytically active Ni 3 N nanoparticles favoring their high accessibility and thereby good charge‐transport within the composite. This is evident from the amount of O 2 evolved (230 mmol h −1 g −1 ), which, to the best of our knowledge, is the highest reported. The work reveals the emergence of COF as supports for electrocatalysts.
Hand in Hand: Tools and techniques for understanding children's touch with a social robot (2016)

Robots that facilitate touch by children have special requirements in terms of safety and robustness, but little is known about how and when children actually use touch with robots. Tools and techniques are required to sense the variety of children's touch and to interpret the volumes of data generated. This explorative user study investigated children's patterns of touch during game play with a robot. We examined where the children touch the robot and their patterns of touch over time, using a raster-based visualisation of each child's time series of touches, recording patterns of touch across different games and children. We found that children readily engage with the robot, in particular spontaneously touching the robot's hands more than any other area. This user study and the tools developed may aid future designs of robots to autonomously detect when they have been touched.
Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles (2020)

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorption on the surface of nanoparticles (NPs) is vital for the development of clinically important protein-based nanomedicine. In this work, new insights on the effect of the different orientation of cytochrome c (cyt c) bound to gold nanoparticles (GNPs) using various ligands on its apoptotic activity is reported. Time-of-Flight Secondary-Ion Mass Spectrometry (ToF- SIMS), electrochemical and circular dichroism (CD) analyses are used to investigate the characteristics of cyt c orientation and structure on functionalized GNPs. These studies indicate that the orientation and position of the heme ring inside the cyt c structure can be altered by changing the surface chemistry on the NPs. A difference in the apoptosis inducing capability because of different orientation of cyt c bound to the GNPs is observed. These findings indicate that the biological activity of a protein can be modulated on the surface of NPs by varying its adsorption orientation. This study will impact on the rational design of new nanoscale biosensors, bioelectronics, and nanoparticle-protein based drugs.
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies (2009)

Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
ENHANCEMENT OF CO2 LASER POWER AND EFFICIENCY BY NEUTRON IRRADIATION (1971)

Experiments have been performed which show that it is possible to increase the efficiency and power of a CO2 laser by irradiating the discharge with energetic α and Li ions produced by the (n, α) reaction with B10. This effect is explained by a tailoring of the electron-energy distribution towards optimum pumping of the laser.
Therapeutic experience of basal cell epithelioma carried out in accordance with a fresh organization method of Mohs. (1992)

64歳, 女性の鼻背部基底細胞上皮腫に対し, Mohsの新鮮組織法 (Mohs micrographicsurgery fresh-tissue technique) に準じた方法で摘出し, 正中前額皮弁により再建した症例を経験した。Mohsの新鮮組織法は, 視診・触診にて, 術前に腫瘍の切除範囲が決定しにくいような基底細胞上皮腫には, 良い適応と思われた。
In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome (2021)

Abstract Late-stage cancer immunotherapy trials often lead to unusual survival curve shapes, like delayed curve separation or a plateauing curve in the treatment arm. It is critical for trial success to anticipate such effects in advance and adjust the design accordingly. Here, we use in silico cancer immunotherapy trials – simulated trials based on three different mathematical models – to assemble virtual patient cohorts undergoing late-stage immunotherapy, chemotherapy, or combination therapies. We find that all three simulation models predict the distinctive survival curve shapes commonly associated with immunotherapies. Considering four aspects of clinical trial design – sample size, endpoint, randomization rate, and interim analyses – we demonstrate how, by simulating various possible scenarios, the robustness of trial design choices can be scrutinized, and possible pitfalls can be identified in advance. We provide readily usable, web-based implementations of our three trial simulation models to facilitate their use by biomedical researchers, doctors, and trialists.
Optical coherence tomography using a continuous-wave, high-power, Raman continuum light source (2004)

High performance, short coherence length light sources with broad bandwidths and high output powers are critical for high-speed, ultrahigh resolution OCT imaging. We demonstrate a new, high performance light source for ultrahigh resolution OCT. Bandwidths of 140 nm at 1300 nm center wavelength with high output powers of 330 mW are generated by an all-fiber Raman light source based on a continuous-wave Yb-fiber laser-pumped microstructure fiber. The light source is compact, robust, turnkey and requires no optical alignment. In vivo, ultrahigh resolution, high-speed, time domain OCT imaging with <5 microm axial resolution is demonstrated.
Paraffin-Inert Atmospheric Solid Analysis Probe: A Fast and Easy Approach To Characterize Extremely Air-Sensitive Organometallic Complexes by Mass Spectrometry (2019)

Rational characterization of most organometallic compounds is hampered by their high reactivity, in particular, toward oxygen and water. Mass spectrometry experiments require physical introduction of the sample in the ionization source. So, the main challenge is to transfer air-sensitive organometallic compounds from inert atmosphere to the ionization source. In this aim, we have developed an easy technique that allows the analysis of air-sensitive compounds using the atmospheric solid analysis probe (ASAP). This method consists of a glass capillary filled with the sample (solid or liquid) and sealed by a paraffin plug to maintain the inert sample until the ionization process. It is illustrated through the structural characterization of a new highly air-sensitive dinuclear zirconium complex supported by an original switchable stilbene platform.
Natural lead-enriched biochar modifies TiO2 photocatalytic activation of sodium persulfate to degrade 2,4-dichlorophenol (2021)

Due to the rapid development of the modern chemical industry, a large amount of chlorophenol pollutants remain in the environment. It poses a serious threat to the ecological environment and human health. Advanced oxidation technologies (AOPs) have the characteristics of mild reaction conditions and strong oxidation capacity, and are currently recognized as safe and effective pollutant treatment technologies. In this study, natural lead-rich biochar materials were used to activate sodium persulfate to degrade 2,4-dichlorophenol, and natural lead-rich biochar modified TiO 2 photocatalytically degraded 2,4-dichlorophenol. Then, using natural lead-rich metal biochar/TiO 2 material, photocatalysis combined with active sodium persulfate to degrade 2,4-dichlorophenol. The experimental results show that the combination of photocatalysis and activated sodium persulfate reaction can completely degrade 100 mg/L 2,4-dichlorophenol under UV light for 3 h, and the degradation efficiency is much higher than the sum of the two separate reactions. Quenching experiments show that SO 4 - • radicals play the most important role in the three free radicals (SO 4 - •, •OH and •O 2 - ) in the advanced oxidation combination system. Finally, the reaction mechanism of the two advanced oxidation combined systems are speculated.
D-band Transceiver Utilizing 70-nm GaAs-mHEMT Technology for FDD System (2019)

This paper presents a D-band transceiver utilizing a 70-nm GaAs metamorphic high electron mobility transistor (mHEMT) technology for a frequency division duplex (FDD) system. The transceiver includes a duplexer, transmitter and receiver modules, an LO and IF circuit board, and a real-time modem. Each module comprises a silica-based package on which D-band converter and E-band multiplier monolithic microwave integrated circuits (MMICs) are mounted using a flip-chip bonding technique. Real-time communication tests are performed at 142- and 157-GHz duplex frequencies. A 10-Gbps transmission with a high spectral efficiency are achieved using a 128 quadrature amplitude modulation (QAM) signal.
Luminescence of Anion Vacancies and Dopant-Vacancy Associates in Stabilized Zirconia (2023)

The desired properties of solid-oxide ionic conductors depend upon the concentration and local environment of mobile ionic species. These species are lattice-oxygen vacancies and vacancy associates. The identity and concentration of these species are implied from the influence of oxygen stoichiometry, dopant concentration, and structure on electrolytic properties. We have recently reported a dependence of the optical properties (absorption and luminescence) on the oxygen stoichiometry and dopant in yttria-stabilized zirconia (YSZ) and erbia-stabilized bismuth oxide (ESB) [1–3]. Absorbance, excitation and emission spectra were ascribed to electronic transitions of F-center type defects (electron-occupied oxygen-vacancies). We proposed a tentative band diagram and defect energy levels for YSZ based upon these results. The spectroscopic characteristics of these materials can provide a better understanding of the behavior of dopants and anion vacancies on the material, and the influence of these species on conductivity and electrocatalysis. In the present paper we present additional luminescence spectra of stabilized zirconia as a function of dopant and dopant concentration.
Multiple WW domains of Nedd4‐1 undergo conformational exchange that is quenched upon peptide binding (2017)

The third WW domain (WW3*) of the ubiquitin ligase human neuronal precursor cell expressed developmentally downregulated gene 4-1 (hNedd4-1) was reported to bind its PY motif peptide by a coupled folding-binding equilibrium. However, it is unknown whether these thermodynamic properties are retained in the context of neighboring hNedd4-1 domains. In this report, NMR data show that the WW3* displays a fold-unfold equilibrium in the presence of neighboring WW domains, and that similar fold-unfold equilibria also likely exist for neighboring WW domains. These equilibria are quenched upon interaction with peptide. Thus, the binding mechanism of hNedd4-1 WW domains to proteins involves coupled folding and binding equilibria, and this mechanism may be a general feature that modulates peptide affinities of WW domains.