gebhart/patrepeval huggingface dataset:
A Mendelian Predisposition to B Cell Lymphoma Caused by IL-10R2 Deficiency (2012)

Abstract Abstract 5092 Background The fact that monogenic interleukin (IL)-10 and IL-10 receptor deficiencies cause very early-onset, severe inflammatory bowel disease demonstrates the IL-10 pathway's crucial role in preventing microbiota-driven gut inflammation. However, no other severe complications of IL-10/IL-10R deficiencies have been reported to date. Methods A cohort of six patients with IL-10/IL-10R deficiency was retrospectively surveyed for phenotypic expression. The identification of a number of cases of lymphoma prompted an in-depth characterization of available biopsy material, with immunohistochemical staining, cytogenetic studies and gene expression profiling. Results Four patients (all with a complete IL-10R2 deficiency) had developed B cell non-Hodgkin's lymphoma between the ages of 5 and 6 years. Cytogenetic and IgH clonality analyses suggested that one of the patients developed at least 3 distinct lymphomas. The patients' tumors had the characteristics of diffuse large B cell lymphomas and contained monoclonal, Epstein-Barr-virus-negative germinal center B cells. Nuclear expression of the NF-κB factor c-REL was detected in all of the six lymphomas tested. Conclusions IL-10R deficiency is associated with a high risk of developing a B cell lymphoma with an unusual phenotype. Our results highlight an unexpected role of the IL-10R pathway in the control of lymphomagenesis. Disclosures: No relevant conflicts of interest to declare.
Dynamic Light Scattering for the Characterization of Polydisperse Fractal Systems: II. Relation between Structure and DLS Results (2008)

Abstract Dynamic light scattering (DLS) is frequently used to characterize suspensions of pyrogenic silica which consists of polydisperse fractal aggregates of sintered spherical primary particles. As the method primarily measures temporal fluctuations of scattered light caused by the translational and rotational diffusive motion of the aggregates it is an important prerequisite to identify those structural properties that are measurable with DLS and to quantify the method's sensitivity to changes in these properties. In a recent paper [1] we have investigated the structure‐hydrodynamics relationship via simulations. Here, the validation of the simulation results by experimental data is presented. Therefore, the structure of different pyrogenic silica grades has been characterized by static light and X‐ray scattering and the diffusional properties were obtained by multi‐angle DLS measurements. It is shown that the hydrodynamic radii determined with DLS scale well with the mean aggregate radius of gyration but that the influence of rotational diffusion has to be accounted for in the measurements.
Antibodies against the VRT101 laminin epitope correlate with human SLE disease activity and can be removed by extracorporeal immunoadsorption (2007)

Anti-VRT101 anibodies are abundantly detected in the serum of patients with SLE and correlate with disease activity. Specific removal of serum anti-VRT101 by extracorporeal plasmapheresis with specific immunoadsorption on the VRT101-coupled sepharose columns may serve as a new therapeutic tool for specific immunoadsorption of pathogenic antibodies in SLE patients.
Suppressing pathological tremor during dextrous teleoperation (2002)

Pathological tremor is suppressed during glove-based dextrous teleoperation using the Weighted-frequency Fourier Linear Combiner algorithm. This is a computationally inexpensive approach which models the tremor and subtracts it out of the incoming command signal. By suppressing the tremor, RMS error was decreased by 57% in tests combining tremor with a simulated grasping motion.
Supplementary Table and Figure Legends from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study (2023)

&lt;p&gt;Supplementary Table and Figure Legends&lt;/p&gt;
Microarchitecture of a High-Radix Router (2005)

Evolving semiconductor and circuit technology has greatly increased the pin bandwidth available to a router chip. In the early 90s, routers were limited to 10Gb/s of pin bandwidth. Today 1Tb/s is feasible, and we expect 20Tb/s of I/O bandwidth by 2010. A high-radix router that provides many narrow Dalports is more effective in converting pin band-width to reduced latency and reduced cost than the alternative of building a router with a few wide ports. However, increasing the radix (or degree) of a router raises several challenges as internal switches and allocators scale as the square of the radix. This paper addresses these challenges by proposing and evaluating alternative microarchitectures for high radix routers. We show that the use of a hierarchical switch organization with per-virtual-channel buffers in each subswitch enables an area savings of 40% compared to a fully buffered crossbar and a throughput increase of 20-60% compared to a conventional crossbar implementation.
The piezo-hall effect in n-silicon for arbitrary crystal orientation (2006)

The piezo-Hall effect describes the change of the Hall coefficient due to mechanical stress. The question arises, if there is any distinct wafer orientation where the piezo-Hall effect is minimized. To this end, a general expression describing the piezo-Hall effect for arbitrary crystal orientation is deduced for the first time. For n-type silicon with low doping concentrations <10/sup 16/ cm/sup -3/ six plots show that the sensitivity of n-doped Hall plates in {111} planes is least influenced by mechanical stress whereas {100} wafer planes are the worst case and 15 times more sensitive to package induced mechanical stress.
A New Focus Servo Method for Magneto-Optical Disk Systems (1987)

The influence of birefringence of a polycarbonate disk upon focus error signals in a magneto-optical disk system is analyzed. We propose a useful focus servo method employing a micro-prism, which is well suited for sampling tracking method.
Stereoselective Hydrogenation of Folic Acid Dimethyl Ester Benzenesulfonate: A New Access to Optically Pure L‐Tetrahydrofolic Acid (2005)

Abstract Folic acid was converted to the corresponding dimethyl ester benzenesulfonate and stereoselectively hydrogenated in organic solvents. An extended screening with rhodium‐ and iridium‐diphosphine catalysts was performed. Under optimized conditions the asymmetric hydrogenation provided a solution of tetrahydrofolic acid dimethyl ester with up to 44% de. The de could be increased to 98% by fractional crystallization of L ‐tetrahydrofolic acid dimethyl ester benzenesulfonate from the hydrogenation mixture. Hydrolysis of the ester afforded optically pure L ‐tetrahydrofolic acid, which can be isolated or converted into its 5‐ or 10‐ or 5,10‐substituted derivatives.
LARGE SUPERFICIAL SQUAMOUS CELL CARCINOMA IN THE SETTING OF ACHALASIA TREATED BY ENDOSCOPIC SUBMUCOSAL DISSECTION: PARTICULAR FEATURES OF SUPERFICIAL CARCINOMA ON STASIS RELATED ESOPHAGEAL HYPERKERATOSIS (2022)

Results A 69-years-old man presented dysphagia and weight loss for several years was referred after the discovery of a 6mm lesion with high-grade dysplasia.
livre de comptes (1929-1934) d'un marchand general de Girardville au Lac-Saint-Jean : (2005)

L'étude que nous présentons porte sur le vocabulaire utilisé de 1929 à 1934 dans le livre de comptes d'un marchand général de Girardville au Lac-Saint-Jean. Dans un premier temps, nous décrivons les us et coutumes des gens de cette époque qui fut particulièrement difficile en milieu rural au Québec en raison de la grande crise économique de 1930. Par la suite, nous nous intéressons à la part occupée par les québécismes dans le corpus. Pour ce faire, nous procédons tout d'abord à un classement onomasiologique de toutes les unités lexicales à partir duquel nous effectuons un classement différentiel afin d'en dégager les québécismes. L'analyse de ces données est présentée dans six chapitres qui correspondent à un thème lexical particulier dans lequel nous présentons la fréquence d'usage et nous analysons la provenance historique de chaque québécisme. L'aspect synonymique est également abordé. Ces résultats sont présentés sous forme de tableaux que nous commentons de manière générale.
Wharf (2018)

Container management frameworks, such as Docker, package diverse applications and their complex dependencies in self-contained images, which facilitates application deployment, distribution, and sharing. Currently, Docker employs a shared-nothing storage architecture, i.e. every Docker-enabled host requires its own copy of an image on local storage to create and run containers. This greatly inflates storage utilization, network load, and job completion times in the cluster. In this paper, we investigate the option of storing container images in and serving them from a distributed file system. By sharing images in a distributed storage layer, storage utilization can be reduced and redundant image retrievals from a Docker registry become unnecessary. We introduce Wharf, a middleware to transparently add distributed storage support to Docker. Wharf partitions Docker's runtime state into local and global parts and efficiently synchronizes accesses to the global state. By exploiting the layered structure of Docker images, Wharf minimizes the synchronization overhead. Our experiments show that compared to Docker on local storage, Wharf can speed up image retrievals by up to 12x, has more stable performance, and introduces only a minor overhead when accessing data on distributed storage.
Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs (2007)

These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder.
Tunable electronic properties by ligand coverage control in PbS nanocrystal assemblies (2019)

Precise ligand coverage control of PbS nanocrystals has been investigated to tune both their assembly structures and electronic properties.
Extraction of Statistical Terms and Co-occurrence Networks from Newspapers (2007)

In this paper, we automatically extract statistical terms and build their co-occurrence networks from newspapers. Statistical terms are expression of the measurements of statistics to watch the movements of phenomena; birth rates, public approval rating of the Cabinet and so on. In recent years, we have a vast amount of available information because of computer-ization and the technologies of making their overview and enhancement of their values are noticed. One of them is the technology of visualizing information of so-cial trend and movements from newspapers. For visu-alizing trend information, there some approaches. In this paper, we take the approach of building networks of causal relations among the statistical terms. To ex-tract statistical terms, we propose extraction method using suffixes. To extract causal relations among sta-tistical terms, we first extract co-occurrence relations and next show them with the networks. We can ex-tract many statistical terms with high accuracy by our method and find interesting links among some statisti-cal terms by our co-occurrence networks. 1
Total synthesis of (+)-pipoxide and (+)-.beta.-senepoxide and their diene precursors (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-pipoxide and (+)-.beta.-senepoxide and their diene precursorsSeiichiro Ogawa and Tohei TakagakiCite this: J. Org. Chem. 1985, 50, 13, 2356–2359Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/jo00213a030https://doi.org/10.1021/jo00213a030research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ATR2 Cala2 from Arabidopsis -infecting downy mildew requires 4 TIR-NLR immune receptors for full recognition (2023)

Summary Arabidopsis Col-0 RPP2A and RPP2B confer recognition of Arabidopsis downy mildew ( Hyaloperonospora arabidopsidis [ Hpa ]) isolate Cala2, but the identity of the recognized ATR2 Cala2 effector was unknown. To reveal ATR2 Cala2 , an F 2 population was generated from a cross between Hpa -Cala2 and Hpa -Noks1. We identified ATR2 Cala2 as a non-canonical RxLR-type effector that carries a signal peptide, a dEER motif, and WY domains but no RxLR motif. Recognition of ATR2 Cala2 and its effector function were verified by biolistic bombardment, ectopic expression and Hpa infection. ATR2 Cala2 is recognized in accession Col-0 but not in Ler-0 in which RPP2A and RPP2B are absent. In ATR2 Emoy2 and ATR2 Noks1 alleles, a frameshift results in an early stop codon. RPP2A and RPP2B are essential for the recognition of ATR2 Cala2 . Stable and transient expression of ATR2 Cala2 under 35S promoter in Arabidopsis and Nicotiana benthamiana enhances disease susceptibility. Two additional Col-0 TIR-NLR (TNL) genes ( RPP2C and RPP2D ) adjacent to RPP2A and RPP2B are quantitatively required for full resistance to Hpa -Cala2. We compared RPP2 haplotypes in multiple Arabidopsis accessions and showed that all 4 genes are present in all ATR2 Cala2 -recognizing accessions.
Ab initio and semiempirical calculations of the hetero‐Diels‐Alder reaction of 1‐aza‐1,3‐butadiene with ethene (1995)

Abstract The transition structures of the hetero‐Diels‐Alder reaction of ( E )‐ and ( Z )‐1‐aza‐1,3‐butadiene ( 8 and 11 ) were studied by means of ab initio (UHF/6‐31+G* and RHF/6‐31+G*) and semiempirical (AM1, PM3) methods. The energy surface of the title reaction was calculated with AM1/CI. Two competing reaction channels exist, a concerted and a two‐step path. All methods used show a preference for the two‐step mechanism in agreement with experimental observations.
Immune and clinical responses in melanoma patients vaccinated with dendritic cells loaded with killed allogeneic melanoma cells (2005)

2509 Background: We demonstrated that dendritic cells (DCs) loaded with killed allogeneic tumors can cross-prime tumor-specific naïve CD8+T cells in vitro. This approach would overcome HLA restriction inherent to peptide vaccines and allow diversification of immune responses including priming of many clones of CD8+ and CD4+T cells. Methods: We now vaccinated 20 patients with metastatic melanoma with autologous monocyte-derived DCs loaded with killed allogeneic Colo829 melanoma cell line (8 vaccines on monthly basis). DCs were generated from monocytes by culturing with GM-CSF and Il-4 and activated by additional culture with TNF and CD40 ligand. KLH was used as a control antigen. Results: As of December 2004, fourteen out of 20 patients are alive. The range of overall survival is 2–22 months, and the range of event-free survival is 1–19 months. Median survival cannot be calculated as yet since 70% of patients are alive. Vaccination is: 1) safe (no autoimmunity); 2) led to the induction of melanoma-specific T cell immunity and, 3) in two patients, long lasting objective clinical responses (one CR and one PR). In this study we have demonstrated in an HLA-A*0201+ patient an induction of melanoma specific immunity thus suggesting cross-priming since the killed melanoma cells used to load the DC vaccine are HLA-A*0201 negative. Furthermore, we have demonstrated the expansion of melanoma-specific T cell immunity in HLA-A*0201 negative patients. Conclusions: The present results justify the design of larger follow up studies to assess the immunological and clinical response to DC vaccines in patients with cancer. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Argos Therapeutics, ODC Therapy
Novel Generation Mycobacterial Adjuvant Based on Liposome-Encapsulated Monomycoloyl Glycerol from Mycobacterium bovis Bacillus Calmette-Guérin (2009)

The immunostimulatory activity of lipids associated with the mycobacterial cell wall has been recognized for several decades and exploited in a large variety of different adjuvant preparations. Previously, we have shown that a mycobacterial lipid extract from Mycobacterium bovis bacillus Calmette-Guérin delivered in cationic liposomes was a particular efficient Th1-inducing adjuvant formulation effective against tuberculosis. Herein, we have dissected the adjuvant activity of the bacillus Calmette-Guérin lipid extract showing that the majority of the activity was attributable to the apolar lipids and more specifically to a single lipid, monomycoloyl glycerol (MMG), previously also shown to stimulate human dendritic cells. Delivered in cationic liposomes, MMG induced the most prominent Th1-biased immune response that provided significant protection against tuberculosis. Importantly, a simple synthetic analog of MMG, based on a 32 carbon mycolic acid, was found to give rise to comparable high Th1-biased responses with a major representation of polyfunctional CD4 T cells coexpressing IFN-gamma, TNF-alpha, and IL-2. Furthermore, comparable activity was shown by an even simpler monoacyl glycerol analog, based on octadecanoic acid. The use of these synthetic analogs of MMG represents a promising new strategy for exploiting the immunostimulatory activity and adjuvant potential of components from the mycobacterial cell wall without the associated toxicity issues observed with complex mycobacterial preparations.
Efficient Sum-Rate Maximization for Medium-Scale MIMO AF-Relay Networks (2016)

We consider the problem of sum-rate maximization in multiple-input multiple-output (MIMO) amplify-and-forward relay networks with multi-operator. The aim is to design the MIMO relay amplification matrix (i.e., the relay beamformer) to maximize the achievable communication sum rate through the relay. The design problem for the case of single-antenna users can be cast as a non-convex optimization problem, which, in general, belongs to a class of NP-hard problems. We devise a method based on the minorization–maximization technique to obtain quality solutions to the problem. Each iteration of the proposed method consists of solving a strictly convex unconstrained quadratic program. This task can be done quite efficiently, such that the suggested algorithm can handle the beamformer design for relays with up to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim 70$ </tex-math></inline-formula> antennas within a few minutes on an ordinary personal computer. Such a performance lays the ground for the proposed method to be employed in medium-scale (or lower regime massive) MIMO scenarios.
Dupilumab: Basic aspects and applications to allergic diseases (2020)

Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding to two types of receptors sharing the IL-4R α chain (IL-4Rα). Since IL-4 and IL-13 play important and redundant roles in the pathogenesis of allergic diseases, blocking both the IL-4 and IL-13 signals would be a powerful and effective strategy for treating allergic diseases. Dupilumab (Dupixent®) is a fully human monoclonal antibody recognizing IL-4Rα and blocking both the IL-4 and IL-13 signals. Dupilumab was first prescribed for atopic dermatitis (AD) patients and has been widely approved for adult patients with moderate to severe AD since 2018. Dupilumab has since been used for asthma, receiving approval for uncontrolled asthma in 2019. A phase 3 study using dupilumab for chronic rhinosinusitis with nasal polyps (CRSwNP) has been just completed, with positive results. Several clinical trials of dupilumab for other diseases in which type 2 inflammation is dominant are now underway. It is hoped that dupilumab will open the door to a new era for treating allergic patients with AD, asthma, and CRSwNP, and for more patients with type 2 inflammations.
Joint 3D reconstruction and deghosting of multisensor streamer data by generalized matching pursuit (2012)

Multichannel reconstruction and 3D deghosting techniques based on multisensor streamer measurements of the pressure wavefield and its associated gradients were recently introduced in literature. In particular, the Generalized Matching Pursuit (GMP) technique was applied to 3D-4C synthetic data bringing significant improvements to address the aliasing arising from sparse crossline sampling. In this abstract, we present an example of real data acquired by an experimental 3D-4C towed cable array and show the performance of GMP applied to the multisensor measurements. The real data examples illustrate that GMP reconstructs and deghosts the pressure wavefield onto a 2D receiver grid uniformly sampled at 6.25 m in both, the inline and the crossline directions, starting from a very limited number of crossline samples at realistic spacings (i.e., 75 m). We describe the main technical challenges due to the nature of the signal and the limitations of the experiment. Despite these challenges, we show that GMP has produced a very effective reconstruction of the three-dimensional wavefield back-scattered by the subsurface for each recorded seismic shot.
Causal complexity demands community coordination (2022)

Yarkoni's argument risks skepticism about the very possibility of social science: If social phenomena are too causally complex, normal scientific methods could not possibly untangle them. We argue that the problem of causal complexity is best approached at the level of scientific communities and institutions, not the modeling practices of individual scientists.
An Edge Detection Approach To Digital Image Stabilization Based On Tri-state Adaptive Linear Neurons (2005)

A new approach to digital image stabilization for video cameras is proposed by using an edge detection method, which is based on tr-state adaptive linear neurons (ADALlNES) [1]. The proposed image stabilizing system efficiently reduces image fluctuation effects caused by human hand instability.