gebhart/patrepeval huggingface dataset:
Functional Testing in the Anterior Cruciate Ligament-Deficient Knee (1993)

Functional testing of patients with anterior cruciate ligament (ACL) deficient knees and normal subjects during stressful activities such as running to a cut and running to a stop and during activities common to daily life, such as walking, stair climbing, and jogging, is presented. Analysis focused on the application of these tests to treatment planning and clinical evaluation. Functional testing during stressful activities indicates that some patients with ACL-deficient knees have higher than normal net hamstring moments during the early phase of these activities. These results suggest dynamic muscular substitution using the hamstrings in patients with chronic ACL-deficient knees. Patients tested during less stressful activities, such as walking and stair climbing, also demonstrated substantial differences from ACL-intact subjects. The majority of patients tended to reduce the net quadriceps moment when the knee was near full extension. Approximately 75% of the patients who were ACL-deficient developed this type of adaptation, which appears to be a subconscious method of avoiding the net anterior pull of the quadriceps mechanism when the knee is near full extension. Functional testing of the ACL-deficient knee provides meaningful information that cannot be obtained by simpler clinical tests. This information can be extremely useful in the selection and evaluation of patients with certain treatment modalities, since it seems to be directly related to some patients' ability to functionally adapt to the loss of the ACL.
Improved Primary-Characteristic Basis Function Method Considering Higher-Order Multiple Scattering (2016)

We propose a novel improved characteristic basis function method (IP-CBFM) for accurately analysing the radar cross section (RCS). This new IP-CBFM incorporates the effect of higher-order multiple scattering and has major influences in analyzing monostatic RCS (MRCS) of single incidence and bistatic RCS (BRCS) problems. We calculated the RCS of two scatterers and could confirm that the proposed IP-CBFM provided higher accuracy than the conventional method while significantly reducing the number of CBF.
SARS-CoV-2 Viral Persistence Based on Cycle Threshold Value and Liver Injury in Patients With COVID-19 (2021)

Liver injury in COVID-19 is linked to a higher SARS-CoV-2 viral load during the early phase of infection, signifying a possible direct viral injury to the liver. Prolonged viral persistence of SARS-CoV-2 is associated with liver injury.
The Lumigraph (2023)

This paper discusses a new method for capturing the complete appearance of bothsynthetic and real world objects and scenes,representing this information, and then using this representation to render images of the object from new camera positions. Unlike the shape capture process traditionally used in computer vision and the rendering process traditionally used in computer graphics, our approach does not rely on geometric representations. Instead we sample and reconstruct a 4D function. which we call a Lumigraph. The Lumigraph is a subset o f the complete plenoptic fu nction that describes the flow of light at all positions in all directions. With the Lumigraph. new images of the object can be generated very quick]y,independentof the geometric or illumination complexity of the scene or object. The paper discusses a complete working system including the capture of sainples. the construction of the Lumigraph, and thesubsequent rendering of images from this new representation.
Moderne nuklearmedizinische Bildgebung - eine Philips-Perspektive (2007)

Philips Medical Systems ist ein globaler Partner bei der medizinischen Bildgebung und Diagnose. Hier wird die Vision von Philips hinsichtlich nicht-invasiver funktionaler Bildgebung beschrieben. Wir motivieren den Ansatz von Philips zur SPECT- und PET-Bildgebung. Beide Modalitäten wurden Untersuchungsverfahren für eine Vielzahl onkologischer, kardiologischer und neurologischer Indikationen. Seit seiner kommerziellen Einführung im Jahr 2001 wurde PET / CT der Goldstandard bei der onkologischen Bildgebung. Philips hat als erste Firma im Jahr 2006 ein Time-of-Flight-basiertes PET-System eingeführt und so eine Wiederbelebung einer Technologie erreicht, die nun im klinischen Alltag dank der Einführung schneller Detektormaterialien und hoch entwickelter Elektronik zur Verfügung steht. Auf Basis der zurzeit verfügbaren Technologien beschreiben wir auch Optionen für verbesserte Bildqualität bei SPECT und PET, die eine höhere diagnostische Genauigkeit für klinische Anwendungen und Forschungsanwendungen bieten könnten.
Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice (2018)

Visceral leishmaniasis (VL) is a chronic parasitic disease caused by <i>Leishmania infantum</i> in the Americas. During VL, several proinflammatory cytokines are produced in spleen, liver, and bone marrow. However, the role of interleukin-32 (IL-32) has not been explored in this disease. IL-32 can induce production of proinflammatory cytokines in innate immune cells and polarize the adaptive immune response. Herein, we discovered that <i>L. infantum</i> antigens induced expression of mRNA mainly for the IL-32γ isoform but also induced low levels of the IL-32β transcript in human peripheral blood mononuclear cells. Furthermore, infection of human IL-32γ transgenic mice (IL-32γTg mice) with <i>L. infantum</i> promastigote forms increased IL-32γ expression in the spleen and liver. Interestingly, IL-32γTg mice harbored less parasitism in the spleen and liver than wild-type (WT) mice. In addition, IL-32γTg mice showed increased granuloma formation in the liver compared to WT mice. The protection against VL was associated with increased production of nitric oxide (NO), interferon gamma (IFN-γ), IL-17A, and tumor necrosis factor alpha by splenic cells restimulated <i>ex vivo</i> with <i>L. infantum</i> antigens. In parallel, there was an increase in the number of Th1 and Th17 T cells in the spleens of IL-32γTg mice infected with <i>L. infantum</i> IL-32γ induction of IFN-γ and IL-17A expression was found to be essential for NO production by splenic cells of infected animals. These data indicate that IL-32γ potentiates the Th1/Th17 immune response during experimental VL, thus contributing to the control of <i>L. infantum</i> infection.
An Isolated Three-Port Bidirectional DC-DC Converter With Decoupled Power Flow Management (2008)

An isolated three-port bidirectional dc-dc converter composed of three full-bridge cells and a high-frequency transformer is proposed in this paper. Besides the phase shift control managing the power flow between the ports, utilization of the duty cycle control for optimizing the system behavior is discussed and the control laws ensuring the minimum overall system losses are studied. Furthermore, the dynamic analysis and associated control design are presented. A control-oriented converter model is developed and the Bode plots of the control-output transfer functions are given. A control strategy with the decoupled power flow management is implemented to obtain fast dynamic response. Finally, a 1.5 kW prototype has been built to verify all theoretical considerations. The proposed topology and control is particularly relevant to multiple voltage electrical systems in hybrid electric vehicles and renewable energy generation systems.
Priority and fair scheduling in a wireless LAN (2002)

In recent years, fair scheduling and quality of service (QoS) in wireless LAN have received significant attention from the networking research community. This paper presents a distributed protocol for priority and fair scheduling in a wireless LAN. The proposed protocol supports multiple priorities, as well as a mechanism (using weights) for controlling the way bandwidth is shared by flows within a given priority level.
Influence of the Furlow Palatoplasty for Patients With Submucous Cleft Palate on Facial Growth (2004)

The purpose of this study was to investigate the facial growth in patients with submucous cleft palate operated on using the Furlow palatoplasty. A total of 30 patients with submucous cleft palate underwent Furlow palatoplasty from 1993 to 1998. The mean follow-up period was 4 years and 3 months. Twenty-five of 30 patients were followed up. Mid-facial growth was measured using lateral cephalograms in 18 patients whose age was greater than 8 years. The parameters obtained in the lateral cephalogram were compared with those of a healthy population in Korea. Eleven (61.1%) of 18 patients observed were within the clinical normal range for the age group for the parameter of the span between the anterior nasal spine and posterior nasal spine, 6 patients (33.3%) were over the range, and 1 patient (5.6%) was below the range. For the sella-nasion-subspinale angle, 55.6% of patients were within the clinical normal range, 27.8% were over the range, and 16.6% were below the range. For the sella-nasion-supramentale angle, 55.6% of patients were within the clinical normal range, 22.2% were over the range, and 22.2% were below the range. For the sella-nasion-subspinale-sella-nasion-supramentale angle, 72.2% of patients were within the clinical normal range, 27.8% were over the range, and none were below the range. For the span between the basion and posterior nasal spine, 50.0% of patients were within the clinical normal range, 27.8% were over the range, and 22.2% were below the range. In conclusion, our results suggest that the Furlow palatoplasty is a useful procedure as an initial treatment of submucous cleft palate and that this technique has a less harmful effect on facial growth because there is no excessive surgical intervention on the hard palate and alveolar process.
Influence of λ-DNA concentration on mobilities and dispersion coefficients during agarose gel electrophoresis (1997)

Earlier works demonstrated theoretically and experimentally that during gel electrophoresis the mobility μ and the dispersion coefficient Dx [reflecting band broadening; G. W. Slater and J. Noolandi (1985) Physics Review Letters, Vol. 55, pp. 1579–1582; T. A. Duke, A. N. Semenov, and J. L. Viovy (1992) Physics Review Letters, Vol. 69, pp. 3260–3263] depend on the chain length, the electric field, and on the gel concentration. Using a Fluorescence Recovery After Photobleaching setup coupled with an electrophoretic cell, we show that they also depend of the DNA concentrationC. Two regimes are observed. The first is analogous to a “dilute” regime in the gel where μ and Dx are DNA concentration independent. In the second regime, μ and Dx decrease when C increases. These results are explained by DNA-DNA interactions. As expected the C* concentration, under which measurements must be carried out to avoid this effect, is found to be the same as the overlap concentration C* determined in solution. Using concentrations of the studied DNA lower than its C*, μ and Dx show a field dependence in good agreement with the predictions of the Biased Reptation model with Fluctuations. © 1997 John Wiley & Sons, Inc. Biopoly 42: 471–478, 1997
Evolution of Mood Symptomatology Through the COVID-19 Pandemic: Findings From the CovidSense Longitudinal Study (2022)

Background The severe acute respiratory syndrome coronavirus 2 global pandemic, with its associated coronavirus disease 2019 (COVID-19) illness, has led to significant mental, physical, social, and economic hardships. Physical distancing, isolation, and fear of illness have significantly affected the mental health of people worldwide. Several studies have documented the cross-sectional elevated prevalence of mental anguish, but due to the sudden nature of the pandemic, very few longitudinal studies have been reported, especially covering the first phase of the pandemic. CovidSense, a longitudinal adaptive study, was initiated to answer some key questions: how did the pandemic and related social and economic conditions affect depression, which groups showed more vulnerability, and what protective factors emerged as the pandemic unfolded? Methodology CovidSense was deployed from April to December 2020. The adaptive design enabled adaption to fluctuating demographics/health status. Participants were regularly queried via SMS messages about their mental health, physical health, and life circumstances. The study included 1,190 participants who answered a total of 18,783 survey panels. This was a prospective longitudinal cohort study following adult participants in the general population through the COVID-19 pandemic. The participant cohort reported self-assessed measures ranging from subjective mood ratings and substance use to validated questionnaires, such as the Quick Inventory of Depressive Symptoms (QIDS) and Cognitive and Affective Mindfulness Scale-Revised (CAMS-R). Results Participants with pre-existing physical (especially pulmonary) or mental conditions had overall higher levels of depression, as measured by the QIDS and self-reported mood. Participants with pre-existing conditions also showed increased vulnerability to the stress caused by watching the news and the increase in COVID-19 cases. Younger participants (aged 18-25 years) were more affected than older groups. People with severe levels of depression had the most variation in QIDS scores, whereas individuals with none to low depressive scores had the most variability in self-reported mood fluctuations. Conclusions The effects of pandemic-related chronic stress were predominant in young adults and individuals with pre-existing mental and medical conditions regardless of whether they had acquired COVID-19 or not. These results point to the possibility of allocating preventive as well as treatment resources based on vulnerability.
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and SARS-CoV-2 variants (2021)

Abstract The COVID-19 pandemic has demonstrated a clear need for high-throughput, multiplexed, and sensitive assays for detecting SARS-CoV-2 and other respiratory viruses as well as their emerging variants. Here, we present microfluidic CARMEN (mCARMEN), a cost-effective virus and variant detection platform that combines CRISPR-based diagnostics and microfluidics with a streamlined workflow for clinical use. We developed the mCARMEN respiratory virus panel (RVP) and demonstrated its diagnostic-grade performance on 533 patient specimens in an academic setting and then 166 specimens in a clinical setting. We further developed a panel to distinguish 6 SARS-CoV-2 variant lineages, including Delta and Omicron, and evaluated it on 106 patient specimens, with near-perfect concordance to sequencing-based variant classification. Lastly, we implemented a combined Cas13 and Cas12 approach that enables quantitative measurement of viral copies in samples. mCARMEN enables high-throughput surveillance of multiple viruses and variants simultaneously.
Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484–509 (2008)

Coagulation factor VIII interacts with several members of the low-density lipoprotein receptor family including low-density lipoprotein receptor-related protein, low-density lipoprotein receptor, and very low-density lipoprotein receptor. The present study was aimed to compare the mechanisms of factor VIII interaction with low-density lipoprotein receptor-related protein, megalin, low-density lipoprotein receptor, and very low-density lipoprotein receptor in order to reveal a general mode of these interactions. Binding of plasma-derived factor VIII and its fragments to recombinant soluble ligand-binding domain of low-density lipoprotein receptor (sLDLR1-7) and purified megalin was studied in solid phase and surface plasmon resonance assays. Full-length factor VIII and its light chain bound to the receptors with similar affinities (KD = 260 +/- 9 and 156 +/- 4 nmol/l, respectively, for megalin and KD = 210 +/- 3 and 174 +/- 13 nmol/l, respectively, for sLDLR1-7). Von Willebrand factor inhibited factor VIII binding to both receptors. In contrast to the light chain, exposure of the high-affinity receptor-binding site within the heavy chain (KD = 22 +/- 4 nmol/l for megalin and 17 +/- 3 nmol/l for sLDLR1-7) required proteolytic cleavage by thrombin. This site was mapped to the A2 domain residues 484-509, based on the inhibitory effects of anti-A2 monoclonal antibody 413, and is shared by all four receptors. Using a panel of A2 mutants, we identified key amino acid residues- positively charged K466, R471, R489 and R490, and hydrophilic residues Y487 and S488- which form the frame of this 'consensus' binding site. We conclude that interaction of factor VIII with the members of the low-density lipoprotein receptor family follows the general mode, requires dissociation of factor VIII from von Willebrand factor, and is activation sensitive.
Chemical Derivatization for Electrospray Ionization Mass Spectrometry. 2. Aromatic and Highly Conjugated Molecules (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Derivatization for Electrospray Ionization Mass Spectrometry. 2. Aromatic and Highly Conjugated MoleculesGary J. Van Berkel and Keiji G. AsanoCite this: Anal. Chem. 1994, 66, 13, 2096–2102Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ac00085a027https://doi.org/10.1021/ac00085a027research-articleACS PublicationsRequest reuse permissionsArticle Views686Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microwave Harmonic Generation in Semiconductors at Low Temperatures. II. Silicon (1969)

A resonance type third harmonic generation (THG) in a magnetic field is observed in n -type silicon under illumination at liquid helium temperatures as in the case of n -type germanium (T. Kamiya et al. : J. Phys. Soc. Japan 27 (1969) 679). A photo-response of the THG is investigated in detail, and the THG shows complicated decay below 2°K after the illumination. This shows that the resonance type THG arises from the multiphoton resonance of electrons in very shallow trapping states. A phenomenological analysis of the complicated dacay is made based on a model, in which there are two series of energy levels in the trapping center, and the thermal ionization energies are obtained to be .63±0.13 meV and 0.42±0.07 meV for each ground state. This result seems to indicate that the obsorved trapping center is attributed to the donor negative ion (D - ). Another experiment on thermally stimulated current (TSC) in n -type silicon is carried out below 1°K, and the depth of the trapping state obtained is almost the same as that observed in the THG experiment.
Joint wireless information and power transfer in a three-node autonomous MIMO relay network (2015)

This paper investigates a three-node amplify-and-forward (AF) multiple-input multiple-output (MIMO) relay network, where an autonomous relay harvests power from the source information flow and is further helped by an energy flow in the form of a wireless power transfer (WPT) at the destination. An energy-flow-assisted two-phase relaying scheme is proposed, where a source and relay joint optimization is formulated to maximize the rate. By diagonalizing the channel, the problem is simplified to a power optimization, where a relay channel pairing problem is solved by an ordering operation. The proposed algorithm, which iteratively optimizes the relay and source power, is shown to converge. Closed-form solutions can be obtained for the separate relay and source optimizations. Besides, a two-phase relaying without energy flow is also studied. Simulation results show that the energy-flow-assisted scheme is beneficial to the rate enhancement, if the transmit power of the energy flow is adequately larger than that of the information flow. Otherwise, the scheme without energy flow would be preferable.
Development of a diva vaccine against Peste des Petits Ruminants by reverse genetic. (2007)

Peste des Petits Ruminants (PPR) is a contagious viral disease of goats, sheep and wildlife in sub-Saharan African countries, Middle East and South-West of Asia. It is caused by a single strand negative RNA virus, belonging to the Paramyxoviridae family and Morbillivirus genus. Current vaccines consist of viral strains attenuated by several passages on cell cultures. These vaccines protect animals against PPR but do not permit the distinction between vaccinated and infected animals, a possibility which could improve surveillance and eradication of the disease. Development of reverse genetic to manipulate negative strand RNA genome is helping us to generate an infectious clone of PPR after cloning the whole genome of the PPR vaccine strain. Then, the objective is to mark this genome with a negative tag by changing B epitopes on the N gene and a positive mark by insertion of a tag between P and M genes. A double marked vaccine of PPR is necessary for the discrimination of vaccinated, infected or vaccinated and concomitantly infected animals. Development of appropriate companion diagnosis tests are also in progress.
Search for physics beyond the standard model in dilepton mass spectra in proton-proton collisions at s = 8 $$ \sqrt{s}=8 $$ TeV (2015)

Dimuon and dielectron mass spectra, obtained from data resulting from protonproton collisions at 8 TeV and recorded by the CMS experiment, are used to search for both narrow resonances and broad deviations from standard model predictions. The data correspond to an integrated luminosity of 20.6 (19.7) fb -1 for the dimuon (dielectron) channel. No evidence for non-standard-model physics is observed and 95% confidence level limits are set on parameters from a number of new physics models. The narrow resonance analyses exclude a Sequential Standard Model Z SSM resonance lighter than 2.90 TeV, a superstring-inspired Z lighter than 2.57 TeV, and Randall-Sundrum Kaluza-Klein gravitons with masses below 2.73, 2.35, and 1.27 TeV for couplings of 0.10, 0.05, and 0.01, respectively. A notable feature is that the limits have been calculated in a model-independent way to enable straightforward reinterpretation in any model predicting a resonance structure. The observed events are also interpreted within the framework of two non-resonant analyses: one based on a large extra dimensions model and one based on a quark and lepton compositeness model with a left-left isoscalar contact interaction. Lower limits are established on M S , the scale characterizing the onset of quantum gravity, which range from 4.9 to 3.3 TeV, where the number of additional spatial dimensions varies from 3 to 7. Similarly, lower limits on , the energy scale parameter for the contact interaction, are found to be 12.0 (15.2) TeV for destructive (constructive) interference in the dimuon channel and 13.5 (18.3) TeV in the dielectron channel.