gebhart/patrepeval huggingface dataset:
Impacts of Cognitive Behavioral Therapy for Insomnia and Pain on Sleep in Women with Gynecologic Malignancies: A Randomized Controlled Trial (2021)

Insomnia is an adverse cancer outcome impacting mood, pain, quality of life, and mortality in cancer patients. Cognitive Behavioral Therapy (CBT) is an evidence-based treatment for diverse psychophysiological disorders, including pain and insomnia. Primarily studied in breast cancer, there is limited research on CBT within gynecology oncology. This study examined CBT effects on subjective and behavioral sleep outcomes: Sleep Efficiency (SE), Sleep Quality (SQ), Total Wake Time (TWT), Sleep Onset Latency (SOL), and Wake After Sleep Onset (WASO). Thirty-five women with insomnia status/post-surgery for gynecologic cancer were randomized to CBT for insomnia and pain (CBTi.p., <i>N</i> = 18) or Psychoeducation (<i>N</i> = 17). Sleep was assessed via sleep diaries and wrist-worn actigraphy at baseline (T1), post-intervention (T2), and two-month follow-up (T3). Intent-to-treat analyses utilizing mixed linear modeling examined longitudinal group differences on sleep controlling for age and advanced cancer. All participants demonstrated improved (1) subjective SE (0.5, <i>p</i> < .01), SOL (-1.2, <i>p</i> < .01), TWT (-1.2, <i>p</i> < .01), and (2) behavioral SE (0.1, <i>p</i> = .02), TWT (-1.2, <i>p</i> = .03), WASO (-0.8, <i>p</i> < .01) across time. Group-level time trends were indicative of higher subjective SE (6.8, <i>p</i> = .02), lower TWT (-40.3, <i>p</i> = .01), and lower SOL (-13.0, <i>p</i> = .05) in CBTi.p. compared to Psychoeducation. Supplemental analyses examining clinical significance and acute treatment effects demonstrated clinical improvements in SE (T1), TWT (T2, T3), and SOL (T3). Remaining effects were not significant. Despite lacking power to detect interaction effects, CBTi.p. clinically improved sleep in women with gynecologic cancers and insomnia during the active treatment phase. Future research will focus on developing larger trials within underserved populations.
Design guidelines for molecules with large hyperpolarizabilities for third-order nonlinear optics (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text U. Gubler, C. Bosshard, P. Günter, R. Martin, R. R. Tykwinski, F. Diederich, V. Alain, and M. Blanchard-Desce, "Design guidelines for molecules with large hyperpolarizabilities for third-order nonlinear optics," in Organic Thin Films for Photonic Applications, OSA Technical Digest (Optica Publishing Group, 1999), paper SaE1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Ultra-low latency 5G CHARISMA architecture for secure intelligent transportation verticals (2017)

We describe low end-to-end latencies of 6.69 ms in the 5G CHARISMA network, that has been optimised for both device and system technologies speed, as well as with its virtualised, hierarchical and distributed, edge-centric architecture, that processes data as near as possible to their source and destination. Such an ultra-high speed 5G network can be utilised in intelligent transport system (ITS) applications, and we describe a public transport bus-based use case that takes advantage of the CHARISMA capabilities.
Effect of Passive Administration of Alloantiserum Containing Antibody against Putative Acceptor(s) for T Cell‐Replacing Factor (TRF) in the Neonatal Stage on Development of B Cell Activity Responsive to TRF (1986)

Previously, we showed that the antiserum raised in male (DBA/2Ha X BALB/c)F1(DCF1) mice (T cell-replacing factor [TRF]-low response animals) by immunizing them with activated B cells from BALB/c mice (TRF-high-responders) contained antibodies against putative TRF-acceptor site(s). We have now evaluated the hypothesis that neonatal treatment of mice with the above antiserum suppresses the development of B cells responsive to TRF. Male DCF1 mouse anti-BALB/c B-cell antiserum or normal DCF1 mouse serum as a control was injected into BALB/c mice within 24 hr after birth. In the antiserum-treated mice, no augmented primary immunoglobulin M (IgM) antibody responses to sheep red blood cells (SRBC) were observed under the conditions in which markedly augmented IgM anti-SRBC responses were induced in control BALB/c mice, suggesting that development of B cells reacting with male DCF1 mouse anti-BALB/c B-cell antiserum is suppressed by the neonatal treatment with the antiserum. Furthermore, the development of B cell activity responsible for helper factors derived from T cells, such as TRF, was markedly suppressed in the neonatally antiserum-treated mice, whereas activity of B cells capable of interacting directly with helper T cells through antigen-bridges was not significantly affected by the same treatment. Such suppression of the B cell activity could be induced only when the antiserum was administered within 48 hr after birth. Moreover, neonatal treatment of mice with the antiserum induced suppressed responsiveness of B cells to a T-independent type 2 antigen, TNP-Ficoll. Neither serum-borne suppressive serum components nor suppressor cells were detected by the system employed. These results support the hypothesis that TRF responsive B cells constitute a subpopulation distinct from the other B cells capable of cooperating with helper T cells via cognate interaction.
Renal Outcomes in High-Risk Hypertensive Patients Treated With an Angiotensin-Converting Enzyme Inhibitor or a Calcium Channel Blocker vs a Diuretic (2005)

In hypertensive patients with reduced GFR, neither amlodipine nor lisinopril was superior to chlorthalidone in reducing the rate of development of ESRD or a 50% or greater decrement in GFR. Participants assigned to receive amlodipine had a higher GFR than those assigned to receive chlorthalidone, but rates of development of ESRD were not different between the groups.
Supplementary Figure 7 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening (2023)

Supplementary Figure 7 from Pericentromeric Instability and Spontaneous Emergence of Human Neoacrocentric and Minute Chromosomes in the Alternative Pathway of Telomere Lengthening
ChemInform Abstract: A Titanocene‐Catalyzed Intramolecular Ene Reaction: Cycloisomerization of Enynes and Dienynes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantum-nondemolition measurement of photon arrival using an atom-cavity system (2007)

A simple and efficient quantum-nondemolition measurement (QND) scheme is proposed in which the arrival of a signal photon is detected without affecting the qubit state. The proposed QND scheme functions even if the ancillary photon is replaced with weak light composed of vacuum and one-photon states. Although the detection scheme is designed for entanglement sharing applications, it is also suitable for general purification of a single-photon state.
Providing metrics and performance feedback in a surgical simulator (2008)

One of the most important advantages of computer simulators for surgical training is the opportunity they afford for independent learning. However, if the simulator does not provide useful instructional feedback to the user, this advantage is significantly blunted by the need for an instructor to supervise and tutor the trainee while using the simulator. Thus, the incorporation of relevant, intuitive metrics is essential to the development of efficient simulators. Equally as important is the presentation of such metrics to the user in such a way so as to provide constructive feedback that facilitates independent learning and improvement. This paper presents a number of novel metrics for the automated evaluation of surgical technique. The general approach was to take criteria that are intuitive to surgeons and develop ways to quantify them in a simulator. Although many of the concepts behind these metrics have wide application throughout surgery, they have been implemented specifically in the context of a simulation of mastoidectomy. First, the visuohaptic simulator itself is described, followed by the details of a wide variety of metrics designed to assess the user's performance. We present mechanisms for presenting visualizations and other feedback based on these metrics during a virtual procedure. We further describe a novel performance evaluation console that displays metric-based information during an automated debriefing session. Finally, the results of several user studies are reported, providing some preliminary validation of the simulator, the metrics, and the feedback mechanisms. Several machine learning algorithms, including Hidden Markov Models and a Naïve Bayes Classifier, are applied to our simulator data to automatically differentiate users' expertise levels.
Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS (2005)

Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and pleiotropic actions in vivo. To promote disease proteomic based drug development for protein therapies, we have attempted to develop an optimal polymer-conjugation system for improving the therapeutic potency of proteins. In this review, we introduce this innovative protein-drug system.
Measurements of top-quark pair to Z-boson cross-section ratios at s = 13 $$ \sqrt{s}=13 $$ , 8, 7 TeV with the ATLAS detector (2017)

Ratios of top-quark pair to Z-boson cross sections measured from protonproton collisions at the LHC centre-of-mass energies of s = 13 TeV, 8 TeV, and 7 TeV are presented by the ATLAS Collaboration. Single ratios, at a given s for the two processes and at different s for each process, as well as double ratios of the two processes at different s, are evaluated. The ratios are constructed using previously published ATLAS measurements of the t t and Z-boson production cross sections, corrected to a common phase space where required, and a new analysis of Z + -where = e, at s = 13 TeV performed with data collected in 2015 with an integrated luminosity of 3.2 fb -1 . Correlations of systematic uncertainties are taken into account when evaluating the uncertainties in the ratios. The correlation model is also used to evaluate the combined cross section of the Z e + e -and the Z + -channels for each s value. The results are compared to calculations performed at next-to-next-to-leading-order accuracy using recent sets of parton distribution functions. The data demonstrate significant power to constrain the gluon distribution function for the Bjorken-x values near 0.1 and the lightquark sea for x < 0.02.
Cholecystokinin 2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma: Results of the Lumed Phase 0a Study (2019)

Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge. For more than 2 decades, it has been known that the cholecystokinin 2 receptor is a promising target for the treatment of MTC with radiolabeled minigastrin analogs. Unfortunately, kidney toxicity has precluded their therapeutic application so far. In 6 consecutive patients, we evaluated with advanced 3-dimensional dosimetry whether improved minigastrin analog <sup>177</sup>Lu-DOTA-(d-Glu)<sub>6</sub>-Ala-Tyr-Gly-Trp-Nle-Asp-PheNH<sub>2</sub> (<sup>177</sup>Lu-PP-F11N) is a suitable agent for the treatment of MTC. <b>Methods:</b> Patients received 2 injections of about 1 GBq (∼80 μg) of <sup>177</sup>Lu-PP-F11N with and without a solution of succinylated gelatin (SG, a plasma expander used for nephroprotection) in a random crossover sequence to evaluate biodistribution, pharmacokinetics, and tumor and organ dosimetry. An electrocardiogram was obtained and blood count and blood chemistry were measured up to 12 wk after the administration of <sup>177</sup>Lu-PP-F11N to assess safety. <b>Results:</b> In all patients, <sup>177</sup>Lu-PP-F11N accumulation was visible in tumor tissue, stomach, and kidneys. Altogether, 13 tumors were eligible for dosimetry. The median absorbed doses for tumors, stomach, kidneys, and bone marrow were 0.88 (interquartile range [IQR]: 0.85-1.04), 0.42 (IQR: 0.25-1.01), 0.11 (IQR: 0.07-0.13), and 0.028 (IQR: 0.026-0.034) Gy/GBq, respectively. These doses resulted in median tumor-to-kidney dose ratios of 11.6 (IQR: 8.11-14.4) without SG and 13.0 (IQR: 10.2-18.6) with SG; these values were not significantly different (<i>P</i> = 1.0). The median tumor-to-stomach dose ratio was 3.34 (IQR: 1.14-4.70). Adverse reactions (mainly hypotension, flushing, and hypokalemia) were self-limiting and not higher than grade 1. <b>Conclusion:</b><sup>177</sup>Lu-PP-F11N accumulates specifically in MTC at a dose that is sufficient for a therapeutic approach. With a low kidney and bone marrow radiation dose, <sup>177</sup>Lu-PP-F11N shows a promising biodistribution. The dose-limiting organ is most likely the stomach. Further clinical studies are necessary to evaluate the maximum tolerated dose and the efficacy of <sup>177</sup>Lu-PP-F11N.
The Rhodium-Catalyzed Cyclotetramerization of Butadiene: Isolation and Structural Characterization of an Intermediate (2000)

The bis(butadiene)rhodium(I) complexes [Rh(s-cis-η4-C4H6)2(PR3)]A readily convert into the isomeric octadienediyl derivatives [Rh(η3:η3-C8H12)(PR3)]A , which are apparently intermediates in the rhodium-catalyzed cyclotetramerization reaction of butadiene. R=iPr, Cy; A=OSO2CF3, B[3,5-(F3C)2C6H3]4; the structure of the complex with iPr and OSO2CF3 is shown. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2000/z14732_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins (2012)

Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found that copper ET sites in proteins also can be constructed without thiolate ligation (called "type zero" sites). Here we report multifrequency electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and nuclear magnetic resonance (NMR) spectroscopic data together with density functional theory (DFT) and spectroscopy-oriented configuration interaction (SORCI) calculations for type zero Pseudomonas aeruginosa azurin variants. Wild-type (type 1) and type zero copper centers experience virtually identical ligand fields. Moreover, O-donor covalency is enhanced in type zero centers relative that in the C112D (type 2) protein. At the same time, N-donor covalency is reduced in a similar fashion to type 1 centers. QM/MM and SORCI calculations show that the electronic structures of type zero and type 2 are intimately linked to the orientation and coordination mode of the carboxylate ligand, which in turn is influenced by outer-sphere hydrogen bonding.
Supplementary Data from Retinoblastoma Tumor Suppressor Gene Expression Determines the Response to Sequential Flavopiridol and Doxorubicin Treatment in Small-Cell Lung Carcinoma (2023)

Supplementary Data from Retinoblastoma Tumor Suppressor Gene Expression Determines the Response to Sequential Flavopiridol and Doxorubicin Treatment in Small-Cell Lung Carcinoma
Structural characterisation of encapsulated nanoparticles inside mesoporous MCM-48 with XRD, TEM and EXAFS (2005)

single-crystal X-ray diffraction (XRD) is not generally used. Here, we wish to show how a combination of powder XRD and advanced solidstate NMR (among other) techniques allow the resolution of the crystal structures of these materials. A brief account of some of the materials properties will also be given.
Mutual Pulling Between Two Oscillators (2014)

Behavior of two mutually coupled phase-locked or free-running oscillators with nearby frequencies is studied. In the case of two free-running mutually coupled oscillators, the two oscillators are either locked to a common frequency, or they undergo through a mutual pulling interaction. It is shown that center frequencies of the pulled oscillators come closer, however, they do not necessarily approach toward each other from opposite directions. It is also demonstrated that the strengths of mutual injections as well as the phase-shifts experienced by the mutually injected signals, affect locations of the two center frequencies. The paper also studies impacts of phase-locked loops on the location and magnitude of the sidebands, when the two mutually coupled oscillators are phase-locked. Effects of the phase-shifts endured by the mutually injected signals on the sidebands are also discussed.
Self-similarity of Internet packet delay (2002)

In this paper we present results which suggest that Internet packet delay, when viewed as a time series, is self-similar in nature. A self-similar phenomenon displays the same or similar statistical properties across a wide range of time scales. Self-similarity has previously been observed in the magnitude of traffic transmitted on local-area and wide-area networks. Our research is the first to explore the self-similarity of traffic delay rather than traffic magnitude. Our results imply that the delay experienced by application layer protocols is extremely bursty and that traditional Poisson models cannot accurately predict the degree of burstiness. Furthermore, we present evidence that the degree of self-similarity for a round-trip path in the Internet may be correlated with the packet loss observed on that path.
Extended Conjugation Platinum(II) Porphyrins for use in Near-Infrared Emitting Organic Light Emitting Diodes (2011)

A family of π-extended platinum(II) porphyrins has been synthesized and incorporated into solution processed polymer light emitting diodes (PLEDs) and vapor deposited multilayer organic light emitting diodes (OLEDs), giving rise to devices with peak emission ranging from 771 to 1005 nm. The longest wavelength emitter, platinum(II)-5,10,15,20-(3,5-di-tert-butylphenyl)tetraanthroporphyrin (Pt-Ar4TAP), shows an emission maximum at 1005 nm, an external quantum efficiency (EQE) of 0.12%, and a maximum radiant emittance (Rmax) of 0.23 mW/cm2 in single layer PLED architectures, which is enhanced to an EQE of 0.20% with an Rmax of 0.57 mW/cm2 upon vapor deposition of an electron transport layer. In an effort to understand substituent effects and enhance the performance of π-extended Pt-porphyrins in PLEDs and OLEDs, a family of Pt-tetrabenzoporphyrins (Pt-TBPs) with varying functionality was investigated. The luminescent lifetimes of the Pt-TBPs in solution and in films were measured, and a strong correlation was demonstrated between the film lifetimes and the PLED and OLED efficiencies. An improvement in external quantum efficiency (EQE) from 2.07 to 2.49% for PLEDs and from 8.0 to 9.2% for OLEDs was observed between the less substituted Pt-tetraphenyltetrabenzoporphyrin and the more substituted Pt-5,10,15,20-(3,5-di-tert-butylphenyl)tetrabenzoporphyrin. The PLED EQEs were further enhanced to 3.02% with the disubstituted Pt-5,15-(3,5-di-tert-butylphenyl)tetrabenzoporphyrin; however, this increase was not observed for the OLEDs where an EQE of 7.8% was measured.
Manufacturable and reliable millimeter wave HJFET MMIC technology using novel 0.15 μm MoTiPtAu gates (2002)

This paper describes a manufacturable and reliable millimeter-wave heterojunction FET (HJFET) MMIC technology, in which a novel 0.15 /spl mu/m MoTiPtAu T-shaped gate has been successfully employed. Excellent DC and RF device characteristics, including Imax of /spl sim/600 mA/mm, BVgd of >10 V and Fmax of /spl sim/200 GHz, were confirmed. High temperature DC-bias tests predict an MTTF of 1.5/spl times/10/sup 7/ hours at a channel temperature of 150/spl deg/C. The 2-stage MMIC amplifier, fabricated using the developed technology, exhibited a 69.5 mW output power with 14.4% power-added efficiency at 56 GHz with good uniformity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A low-noise durable transmissive stamper for multi-layer discs using phase transition mastering (2006)

ABSTRACT We developed a negative-type photoresist of WOx film and obtained a low noise groove. We also confirmed a feasibility of the transmissive stamper using the WOx film for multi-layer discs. Keywords: phase transition mastering, stamper, multi-layer, blue laser lithography, UV laser lithography, inorganic photoresist, space layer, forward stacking method 1. INTRODUCTION A considerable number of studies have been made on high-density optical disc mastering using deep UV lithography [1], near field lithography [2] or electron beam lithography [3]. Kouchiyama et al. proposed blue laser lithography (O =405nm, NA0.95) using an inorganic positive-type photoresist of transition metal oxide film [4]. Shintani et al. and Miura et al. proposed blue laser lithography ( O =405nm, NA0.85) using negative-type photoresist of GeSbTe film [5] and ZnS-SiO 2 film [6], respectively. Ito et al. proposed UV laser lithography (O =351nm, NA0.9) using the positive-type photoresist of TeOx-based f ilm [7]. These phase transition mastering (PTM ) techniques achieved an areal density of a 25GB Blu-ray disc (BD) ROM without expensive mastering equipment. On the other hand, it has been recognized that multi-layer recording [8] is very helpful in increasing the entire capacity of a disc. However, multi-layer recording suffers from deterioration in the signal to noise ratio, so it requires a low-noise groove. Th e thickness of the space layer between recording layers must also be accurately controlled, since spherical aberration due to thickness errors causes significant problems for multi-layer recording. Moreover, a disposable plastic stamper, used in the process of making the space layer, incurs much cost. In this paper, we propose a durable transmissive stamper fo r multi-layer discs instead of using a disposable plastic stamper, utilizing UV laser lithography ( O =351nm, NA0.9) with a negative-type photoresist of transmissive WOx film. The low-noise characteristics of the replicated groove from the stamper and improvement in thickness accuracy of the space layer are demonstrated.
Supplementary Figure 2 from <i>In Vitro</i> and <i>In Vivo</i> Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer (2023)

&lt;p&gt;PDF - 207K, A: Untreated KLM-1 tumors stain strongly for mesothelin. B-D: Mesothelin expression is not affected by treatment with RG7787, paclitaxel or both. IHC was done by Histoserv, Inc. according to a standard protocol. Representative pictures (10X) are shown.&lt;/p&gt;