gebhart/patrepeval huggingface dataset:
Enantioselective Synthesis of (‐)‐Terpestacin and Structural Revision of Siccanol Using Catalytic Stereoselective Fragment Couplings and Macrocyclizations. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
<title>Reconfigurable electro-optic interconnects using holographic elements</title> (1998)

A new device concept for fabricating polymer-based reconfigurable electro-optic interconnects based on a guide-wave electro-optic beam deflector in conjunction with multiplexed waveguide holograms is presented. The presented device takes fully advantage of a thin-film electro-optic prism array and multiplexed waveguide holograms, capable of reconfiguring more than 50 optical interconnection channels using a single electrode and a single electrical driving source. No any moving component and DC bias are required. The presented device is advantageous whenever there is a need for high-speed, reliable, compact, los- loss and low-power reconfigurable optical interconnection.
Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600–Mutant Anaplastic Thyroid Cancer (2017)

Purpose We report the efficacy and safety of dabrafenib (BRAF inhibitor) and trametinib (MEK inhibitor) combination therapy in BRAF V600E-mutated anaplastic thyroid cancer, a rare, aggressive, and highly lethal malignancy with poor patient outcomes and no systemic therapies with clinical benefit. Methods In this phase II, open-label trial, patients with predefined BRAF V600E-mutated malignancies received dabrafenib 150 mg twice daily and trametinib 2 mg once daily until unacceptable toxicity, disease progression, or death. The primary end point was investigator-assessed overall response rate. Secondary end points included duration of response, progression-free survival, overall survival, and safety. Results Sixteen patients with BRAF V600E-mutated anaplastic thyroid cancer were evaluable (median follow-up, 47 weeks; range, 4 to 120 weeks). All patients had received prior radiation treatment and/or surgery, and six had received prior systemic therapy. The confirmed overall response rate was 69% (11 of 16; 95% CI, 41% to 89%), with seven ongoing responses. Median duration of response, progression-free survival, and overall survival were not reached as a result of a lack of events, with 12-month estimates of 90%, 79%, and 80%, respectively. The safety population was composed of 100 patients who were enrolled with seven rare tumor histologies. Common adverse events were fatigue (38%), pyrexia (37%), and nausea (35%). No new safety signals were detected. Conclusion Dabrafenib plus trametinib is the first regimen demonstrated to have robust clinical activity in BRAF V600E-mutated anaplastic thyroid cancer and was well tolerated. These findings represent a meaningful therapeutic advance for this orphan disease.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads (2022)

Inhibition of the <i>S</i>-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal target in cancers with the deletion of the methylthioadenosine phosphorylase (MTAP) gene. Here, we report the identification of novel MAT2A inhibitors with distinct <i>in vivo</i> properties that may enhance their utility in treating patients. Following a high-throughput screening, we successfully applied the structure-based design lessons from our first-in-class MAT2A inhibitor, <b>AG-270</b>, to rapidly redesign and optimize our initial hit into two new lead compounds: a brain-penetrant compound, <b>AGI-41998</b>, and a potent, but limited brain-penetrant compound, <b>AGI-43192</b>. We hope that the identification and first disclosure of brain-penetrant MAT2A inhibitors will create new opportunities to explore the potential therapeutic effects of SAM modulation in the central nervous system (CNS).
The Complexity of Tree Automata and Logics of Programs (Extended Abstract) (1988)

We investigate the (computational) com- plexity of testing nonemptiness of finite state automata on infinite trees. We show that for tree automata with m states and n pairs nonemptiness can be tested in time O((m~z)~), even though we show that the problem is in general NP-complete. The new nonemptiness algorithm enables us to obtain exponentially improved, essentially tight upper bounds for numerous important modal log- ics of programs, interpreted with the usual semantics over structures generated by binary relations. For example, we show that satisfiability for the full branching time logic CTL* can be tested in deterministic double exponential time. It also follows that satisfiability for Propositional Dynamic Logic with a repetition construct (PDL-delta) and for the Propositional Mu-calculus (L p) can be teated in deterministic single exponential time.
Mode Coupling and Nonlinear Resonances of MEMS Arch Resonators for Bandpass Filters (2017)

We experimentally demonstrate an exploitation of the nonlinear softening, hardening, and veering phenomena (near crossing), where the frequencies of two vibration modes get close to each other, to realize a bandpass filter of sharp roll off from the passband to the stopband. The concept is demonstrated based on an electrothermally tuned and electrostatically driven MEMS arch resonator operated in air. The in-plane resonator is fabricated from a silicon-on-insulator wafer with a deliberate curvature to form an arch shape. A DC current is applied through the resonator to induce heat and modulate its stiffness, and hence its resonance frequencies. We show that the first resonance frequency increases up to twice of the initial value while the third resonance frequency decreases until getting very close to the first resonance frequency. This leads to the phenomenon of veering, where both modes get coupled and exchange energy. We demonstrate that by driving both modes nonlinearly and electrostatically near the veering regime, such that the first and third modes exhibit softening and hardening behavior, respectively, sharp roll off from the passband to the stopband is achievable. We show a flat, wide, and tunable bandwidth and center frequency by controlling the electrothermal actuation voltage.
Effects of Display Sizes on a Scrolling Task using a Cylindrical Smartwatch (2015)

With a growing interest in wrist-worn devices, research has typically focused on expanding the available interaction area for smartwatches. In this paper, we instead investigate how different display sizes influence task performance, while maintaining a consistent input area. We conducted an experiment in which users completed a scrolling task using a small display, a large display, and a cylindrical display wrapped around the wrist. We found that the large and cylindrical displays resulted in faster task performances than the small display. We also found that the cylindrical display removed constraints on the participants' body pose, suggesting that cylindrical displays have unique benefits for mobile interactions.
Playing the trade-off game (2009)

Modern mobile devices need to be extremely energy efficient. Due to the growing complexity of these devices, energy-aware design exploration has become increasingly important. Current exploration tools often do not support energy estimation, or require the design to be very detailed before estimation is possible. It is important to get early feedback on both performance and energy consumption during all phases of the design and at higher abstraction levels. This article presents a unified optimization and exploration framework to explore source-level transformation to processor architecture design space. The proposed retargetable compiler and simulator framework can map applications to a range of processors and memory configurations, simulate, and report detailed performance and energy estimates. An accurate and consistent energy modeling approach is introduced which can estimate the energy consumption of processor and memories at a component level, which can help to guide the design process. Fast energy-aware architecture exploration is illustrated by modeling both state-of-the-art processors as well as other architectures. Various design trade-offs are also illustrated on different academic as well as industrial benchmarks from both the wireless communication and multimedia domain. We also illustrate a design space exploration on different applications and show that there is large trade-off space between application performance, energy consumption, and area. We show that the proposed framework is consistent, accurate, and covers a large design space including various novel low-power extensions in a unified framework.
Characteristics of the evolution of lasing in electron-beam-pumped semiconductor lasers (1988)

A new approach to the description of the dynamics of semiconductor lasers is suggested on the basis of a model proposed previously. It is shown that this approach can describe from a unified standpoint both spiking emission and changes in the emission spectrum during a pump pulse.
PARADISE (1997)

This paper presents PARADISE (PARAdigm for DIalogue System Evaluation), a general framework for evaluating spoken dialogue agents. The framework decouples task requirements from an agent's dialogue behaviors, supports comparisons among dialogue strategies, enables the calculation of performance over subdialogues and whole dialogues, specifies the relative contribution of various factors to performance, and makes it possible to compare agents performing different tasks by normalizing for task complexity.
Maximized Hole Trapping in a Polystyrene Transistor Dielectric from a Highly Branched Iminobis(aminoarene) Side Chain (2021)

We synthesized highly branched and electron-donating side chain subunits and attached them to polystyrene (PS) used as a dielectric layer in a pentacene field-effect transistor. The influence of these groups on dielectric function, charge retention, and threshold voltage shifts (Δ<i>V</i><sub>th</sub>) depending on their positions in dielectric multilayers was determined. We compared the observations made on an <i>N</i>-perphenylated iminobisaniline side chain with those from the same side chains modified with ZnO nanoparticles and with an adduct formed from tetracyanoethylene (TCNE). We also synthesized an analogue in which six methoxy groups are present instead of two amine nitrogens. At 6 mol % side chain, hopping transport was sufficient to cause shorting of the gate, while at 2 mol %, charge trapping was observable as transistor threshold voltage shifts (Δ<i>V</i><sub>th</sub>). We created three types of devices: with the substituted PS layer as single-layer dielectric, on top of a cross-linked PS layer but in contact with the pentacene (bilayers), and sandwiched between two PS layers in trilayers. Especially large bias stress effects and Δ<i>V</i><sub>th</sub>, larger than those in the case of the hexamethoxy and previously studied dimethoxy analogues, were observed in the second case, and the effects increased with the increasing electron-donating properties of the modified side chains. The highest Δ<i>V</i><sub>th</sub> was consistent with a majority of the side chains stabilizing the trapped charge. Trilayer devices showed decreased charge storage capability compared to previous work in which we used less donating side chains but in higher concentrations. The ZnO and TCNE modifications resulted in slightly more and less negative Δ<i>V</i><sub>th</sub>, respectively, when the side chain polystyrene was not in contact with the pentacene and isolated from the gate electrode. The results indicate a likely maximum combination of molecular charge stabilizing activity and side chain concentration that still allows gate dielectric function.
Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide (2007)

The glycosyltransferase enzymes (Lgts) responsible for the biosynthesis of the lipooligosaccharide-derived oligosaccharide structures from Moraxella catarrhalis have been investigated. This upper respiratory tract pathogen is responsible for a spectrum of illnesses, including otitis media (middle ear infection) in children, and contributes to exacerbations of chronic obstructive pulmonary disease in elderly patients. To investigate the function of the glycosyltransferase enzymes involved in the biosynthesis of lipooligosaccharide of M. catarrhalis and to gain some insight into the mechanism of serotype specificity for this microorganism, mutant strains of M. catarrhalis were produced. Examination by NMR and MS of the oligosaccharide structures produced by double-mutant strains (2951lgt1/4Delta and 2951lgt5/4Delta) and a single-mutant strain (2951lgt2Delta) of the bacterium has allowed us to propose a model for the serotype-specific expression of lipooligosaccharide in M. catarrhalis. According to this model, the presence/absence of Lgt4 and the Lgt2 allele determines the lipooligosaccharide structure produced by a strain. Furthermore, it is concluded that Lgt4 functions as an N-acetylglucosylamine transferase responsible for the addition of an alpha-D-GlcNAc (1-->2) glycosidic linkage to the (1-->4) branch, and also that there is competition between the glycosyltransferases Lgt1 and Lgt4. That is, in the presence of an active Lgt4, GlcNAc is preferentially added to the (1-->4) chain of the growing oligosaccharide, instead of Glc. In serotype B strains, which lack Lgt4, Lgt1 adds a Glc at this position. This implies that active Lgt4 has a much higher affinity/specificity for the beta-(1-->4)-linked Glc on the (1-->4) branch than does Lgt1.
Role of radiation-induced circulating myeloid-derived suppressor cells on systemic lymphopenia after chemoradiotherapy for glioblastoma (2022)

Severe and prolonged lymphopenia frequently occurs in glioblastoma patients after standard chemoradiotherapy and has been associated with significantly worse survival, but its biological mechanism is not well understood. To address this we performed a correlative study designed to prospectively collect and evaluate peripheral blood of glioblastoma patients treated with chemoradiotherapy using genomic and immune monitoring technologies. The RNA sequencing analysis of the peripheral blood mononuclear cells (PBMC) showed an elevated level of myeloidderived suppressor cells (MDSC) regulatory genes in the lymphopenic patients (LP) when compared to non-lymphopenic patients (NLP) after chemoradiotherapy. Additional analysis using flow cytometry and single-cell RNA sequencing further confirmed increased number of circulating MDSC in LP when compared to NLP after chemoradiotherapy. Preclinical murine models were also established to recapitulate this phenomenon and demonstrated a causal relationship between radiation-induced MDSC and systemic lymphopenia using transfusion and depletion experiments. Pharmacological inhibition of MDSC using arginase-1 inhibitor (CB1158) or phosphodiesterase5 inhibitor (tadalafil) during RT successfully abrogated radiation-induced lymphopenia and improved survival in the preclinical models.
Modeling of software concerns in Cosmos (2002)

Separation of concerns is a well-established principle of software engineering. Nevertheless, the failure to separate concerns effectively has been identified as a continuing cause of the ongoing software crisis. This failure arises in part because most programming and modeling formalisms enforce a dominant decomposition that allows only a few concerns to be separated, whereas software in reality is subject to multiple simultaneous, overlapping, and crosscutting concerns.Several approaches to "advanced separation of concerns" have been proposed, including subject-oriented programming, aspect-oriented programming, and Hyperspaces. These focus mainly on coding but take a multidimensional view of concerns that applies across the software life cycle. To support such approaches, we are developing Cosmos, a general-purpose concern-space modeling schema. Cosmos distinguishes logical and physical concerns. Logical concerns include classifications, classes, instances, properties, and topics, physical include instances, collections, and attributes. Cosmos also identifies four categories of relationship, including categorical, interpretive, mapping, and physical. Cosmos can support software development activities such as rationale capture, impact analysis, compositional development, change propagation, customization, and reuse.
Emission lifetimes of tungsten carbonyl complexes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEmission lifetimes of tungsten carbonyl complexesMark. Wrighton, George S. Hammond, and Harry B. GrayCite this: Inorg. Chem. 1972, 11, 12, 3122–3124Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/ic50118a054https://doi.org/10.1021/ic50118a054research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
N-acyliminium ion cyclisations in natural product chemistry: Synthesis of gelsemine (1994)

Abstract
Chemometrics—the key to sensor array development (1991)

S. J. Haswell, A. D. Walmsley, R. J. Forster and D. Diamond, Anal. Proc., 1991, 28, 115 DOI: 10.1039/AP9912800115
Envisioning a robust, scalable metacognitive architecture built on dimensionality reduction (2010)

One major challenge of implementing a metacognitive architecture lies in its scalability and flexibility. We postulate that the difference between a reasoner and a metareasoner need not extend beyond what inputs they take, and we envision a network made of many instances of a few types of simple but powerful reasoning units to serve both roles. In this paper, we present a vision and motivation for such a framework with reusable, robust, and scalable components. This framework, called Scruffy Metacognition, is built on a symbolic representation that lends itself to processing using dimensionality reduction and principal component analysis. We discuss the components of such as system and how they work together for metacognitive reasoning. Additionally, we discuss evaluative tasks for our system focusing on social agent role-playing and object classification.
Engineering Escherichia coli Co‐Cultures for Production of Curcuminoids From Glucose (2017)

Curcuminoids (cus) have attracted increasing attention because of the antioxidant, anticancer, and antitumor activities while their production is limited because of its main source, turmeric plant, demonstrates extensive seasonal variation. In this study, we constructed Escherichia coli co-culture system for the rapid production of curcuminoids from glucose. Firstly, the overexpression of curcuminoid synthase and four different strategies related to increasing the intracellular malonyl-CoA pool were conducted in engineered E. coli. We found that bisdemethoxycurcumin (BDMC) is the main product and that high level of malonyl-CoA pool is essential for BDMC production. We also obtained the maximum titer (13.8 mg L<sup>-1</sup> ) of BDMC within 4 h by fast preparation directly from p-coumaric acid. Secondly, we developed a process for BDMC synthesis from glucose using a co-culture system where an E. coli strain is used to produce p-coumaric acid from glucose and another E. coli strain converted p-coumaric acid into the final product. Compared to the mono-culture system, the co-culture is more potent and resulted in 6.28 mg L<sup>-1</sup> of BDMC from glucose within 22 h of fermentation in a 3-L bioreactor. This is the first time a co-culture method is employed for the production of curcuminoids from glucose in a lab scale bioreactor. This system provides a new method transforming inexpensive substrate into value-added products.
Biological activities of extract from Coleonema album in vitro (2019)

Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method.
Transport Property and Charge Trap Comparison for N-Channel Perylene Diimide Transistors with Different Air-Stability (2010)

N-type organic field-effect transistors (OFETs), based on two perylene diimide semiconductors (PDI-8 and PDI-8CN2) exhibiting very different air sensitivities, have been fabricated on Si/SiO2 substrates. These OFETs have been electrically characterized in vacuum both in the dark and under white-light illumination by dc transfer and output curves, bias stress experiments and variable temperature measurements. In particular, the combination of variable temperature and light illumination experiments is shown to be a powerful tool to clarify the influence of charge trapping on the device operation. Even if, in vacuum, the air-sensitive PDI-8 devices display slightly better performances in terms of field-effect mobility and maximum current values, according to our results, charge transport in PDI-8 films is much more affected by charge trap states compared to PDI8-CN2 devices. These trapping centers are mainly active above 180 K, and their physical nature can be basically ascribed to the interaction between silanol groups and water molecules absorbed on SiO2 surface that is more active above the H2O supercooled transition temperature.
Diamond machining of flats, spherics, and aspherics (1990)

This paper describes a study of single point natural diamond machining techniques applied to machining flats, spherics and aspherics. It begins by examining four critical features of the diamond machining process that must be understood and applied before flats, spherics and aspherics can be diamond machined. The four critical features are as follows:- The unique physical properties of natural diamond that make it the ideal material for micro precision machining. The high quality machine design principles that must be applied to obtain optical surfaces and form. The design features of component fixturing for successful production of metal optics. How the accuracy and form stability of precision diamond machined optical components depend on the choice of material and the quality of the blank.
Multi-contact quantum dot superluminescent diodes for optical coherence tomography (2008)

Multi-contact chirped quantum dot superluminescent diodes are characterized with regard to key parameters for image quality in optical coherence tomography systems. By independently tuning power and spectral shape, the penetration depth and resolution are decoupled.