gebhart/patrepeval huggingface dataset:
Functional connectivity magnetic resonance imaging classification of autism (2011)

Group differences in resting state functional magnetic resonance imaging connectivity between individuals with autism and typically developing controls have been widely replicated for a small number of discrete brain regions, yet the whole-brain distribution of connectivity abnormalities in autism is not well characterized. It is also unclear whether functional connectivity is sufficiently robust to be used as a diagnostic or prognostic metric in individual patients with autism. We obtained pairwise functional connectivity measurements from a lattice of 7266 regions of interest covering the entire grey matter (26.4 million connections) in a well-characterized set of 40 male adolescents and young adults with autism and 40 age-, sex- and IQ-matched typically developing subjects. A single resting state blood oxygen level-dependent scan of 8 min was used for the classification in each subject. A leave-one-out classifier successfully distinguished autism from control subjects with 83% sensitivity and 75% specificity for a total accuracy of 79% (P = 1.1 × 10(-7)). In subjects <20 years of age, the classifier performed at 89% accuracy (P = 5.4 × 10(-7)). In a replication dataset consisting of 21 individuals from six families with both affected and unaffected siblings, the classifier performed at 71% accuracy (91% accuracy for subjects <20 years of age). Classification scores in subjects with autism were significantly correlated with the Social Responsiveness Scale (P = 0.05), verbal IQ (P = 0.02) and the Autism Diagnostic Observation Schedule-Generic's combined social and communication subscores (P = 0.05). An analysis of informative connections demonstrated that region of interest pairs with strongest correlation values were most abnormal in autism. Negatively correlated region of interest pairs showed higher correlation in autism (less anticorrelation), possibly representing weaker inhibitory connections, particularly for long connections (Euclidean distance >10 cm). Brain regions showing greatest differences included regions of the default mode network, superior parietal lobule, fusiform gyrus and anterior insula. Overall, classification accuracy was better for younger subjects, with differences between autism and control subjects diminishing after 19 years of age. Classification scores of unaffected siblings of individuals with autism were more similar to those of the control subjects than to those of the subjects with autism. These findings indicate feasibility of a functional connectivity magnetic resonance imaging diagnostic assay for autism.
The Invisible Arm of Immunity in Common Cancer Chemoprevention Agents (2013)

Immunoprevention refers to a strategy of preventing pathogen-associated and spontaneous cancers through the use of vaccines, antibodies, and immune modulators. Immune modulators function by enhancing the endogenous ability of the immune system to monitor for malignancy, so-called "immunosurveillance." There is growing evidence that many of the most promising cancer chemoprevention agents including aspirin, COX-2 inhibitors, aromatase inhibitors, and bisphosphonates mediate their effects, in part, by enhancing immunosurveillance and reversing the immune evasive mechanisms that premalignant lesions use. In the following review, we introduce critical components of the human immune surveillance system-dendritic cells, T cells, and immune suppressive cells-and discuss the emerging data suggesting that common chemoprevention agents may modulate the function of these immunologic cells.
A numerical solution of the Boltzmann equation for high-powered short pulse microwave breakdown in nitrogen (1989)

A theoretical formulation that provides a basis for generating approximate solutions of the Boltzmann equation for the study of high-powered microwave pulses interacting with a background atmosphere is given. A numerical scheme is implemented using realistic cross sections for electron–nitrogen collisions, including excitation and ionization. It is found that the numerical results agree well with previous experimental and theoretical values when α is less than about 0.1 kV/cm Torr, where α is the effective electric field divided by the pressure (α=Ee/P). Results are presented providing a simple fit for the time averaged momentum transfer rate and the ionization rate as a function of the microwave electric field E, wavelength λ, and gas pressure P, for 0.1≤α≤1.0 kV/cm Torr. This fit is compared with recent experimental data for breakdown times.
Synergy between the metal nanoparticles and the support for the hydrogenation of functionalized carboxylic acids to diols on Ru/TiO2 (2011)

Ruthenium nanoparticles supported on titania are over three times more active than conventional ruthenium on carbon for the hydrogenation of lactic acid. This superior catalytic activity can be due to a combined action of small ruthenium nanoparticles and the titania support.
Design validation of prototype ultra-wideband linear polyfractal antenna arrays (2008)

This paper focuses on the design, construction, and testing of two prototype 32-element, ultra-wideband polyfractal antenna arrays and compares their performance with numerical simulations.
A heuristic to capture multi-directional lateral tactile perception (2011)

Abstract Multi-directional tactile perception adds significant complexity when interpreting haptic experimental data. In perceiving tactile stimulus direction, we often observe a lack of one-to-one stimulus-response compatibility, mostly due to confounding sensations that reinforce and/or distort a primary stimulus. This study presents the development of a metric to capture multi-directional lateral tactile perception on a finger pad. Sixty-two subjects rated the direction and magnitude of lateral motion from a single probe moving in one of the eight possible directions. A heuristic based on a vector matrix was developed to capture and integrate the relative contribution of each subject's rated directional perception in x–y coordinates. This article explains the theoretical underpinnings and the justifications for this heuristic and highlights the usefulness of this approach for future haptic system designs. Keywords: hapticsmulti-directional tactile perceptionpercept vectorjust noticeable differenceresponse magnitude Acknowledgements The authors thank Dr Kurt Palmer for his contribution to the design of experiment and the statistical data analysis.
Annexin 2 Mediates Plasminogen-Related Recruitment of Neovascular Mural Cells in Lymphoma Angiogenesis. (2007)

Abstract Malignant tumor progression requires the development of tumor-associated blood vessels through co-option of nearby host vascular cells, recruitment of marrow-derived progenitor cells, or both. The annexin 2 (A2)/p11 heterotetramer is a cell surface co-receptor for the fibrinolytic proteins plasminogen (Plg) and tPA, and strongly augments the catalytic efficiency of vascular cell plasmin generation. We showed previously that A2−/ − mice display impaired postnatal angiogenesis in the corneal pocket, oxygen-induced retinopathy, and Matrigel plug assays. Here, we examined neovascularization of experimental lymphoma in mice with fibrinolytic deficiency states. For both EL4, a T cell lymphoma, and B6RV2, a B cell lymphoma, growth of implanted tumor cells was rapid in wildtype and tPA−/ − mice, but nearly flat in both A2−/ − and Plg−/ − mice. Immunohistochemical staining of EL4 tissue on day 8 revealed reduced vascular density, frequent intravascular fibrin thrombi, and dilated microvessels in A2−/ −, compared with A2+/+, mice. Electron microscopy and immunofluorescence revealed a striking paucity of pericytes and secondary dropout of endothelial cells within A2−/ − tumor microvessels. Flow cytometric analysis of circulating progenitor cells showed reduced recruitment of VEGFR1+/CD11b+ hematopoietic precursors from bone marrow to blood in A2−/ − versus A2+/+ tumor-bearing mice. In lethally irradiated A2−/ − mice, moreover, tumor growth was rescued completely upon engraftment with A2+/+ marrow. Transplantation of green fluorescent protein (GFP)-labeled A2+/+ bone marrow revealed the appearance of abundant marrow-derived CD11b+/CD68+ cells closely apposed to developing tumor neovessels. Many of these cells also express the pericyte marker, NG2. Transplantation of A2+/+ marrow, finally, restored the investment of tumor microvessels with α-smooth muscle actin-positive pericytes. These data suggest that A2 contributes critically to tumor angiogenesis in experimental lymphoma in mice, by enabling recruitment of A2+ myelomonocytic cells that promote neovascular stabilization by pericyte-like cells. The data suggest further that targeting the A2/p11 system could offer a novel strategy for the treatment of malignant lymphoma.
Editorial: Introduction to the Special Issue on Deep Learning for High-Dimensional Sensing (2022)

The papers in this special section focus on deep learning for high-dimensional sensing. People live in a high-dimensional world and sensing is the first step to perceive and understand the environment for both human beings and machines. Therefore, high-dimensional sensing (HDS) plays a pivotal role in many fields such as robotics, signal processing, computer vision and surveillance. The recent explosive growth of artificial intelligence has provided new opportunities and tools for HDS, especially for machine vision. In many emerging real applications such as advanced driver assistance systems/autonomous driving systems, large-scale, high-dimensional and diverse types of data need to be captured and processed with high accuracy and in a real-time manner. Bearing this in mind, now is the time to develop new sensing and processing techniques with high performance to capture high-dimensional data by leveraging recent advances in deep learning (DL).
A Novel Low-Temperature Non-Corrosive Sulfate/Sulfide Scale Dissolver (2020)

The oil and gas production operations suffer from scale depositions. The scale precipitations have a damaging impact on the reservoir pores, perforations, downhole and completion equipment, pipeline network, wellhead chokes, and surface facilities. Hydrocarbon production possibly decreased because of the scale accumulation in the well tubular, leading to a well plugging, this requires wells to be shut-in in severe cases to perform a clean-out job. Therefore, scale deposition is badly affecting petroleum economics. This research aims to design a scale dissolver with low cost, non-damaging for the well equipment and has a high performance at the field operating conditions. This paper presents a novel non-corrosive dissolver for sulfate and sulfide composite scale in alkaline pH and works at low-temperature conditions. The scale samples were collected from a production platform from different locations. A complete description of the scale samples was performed as X-ray diffraction (XRD) and X-ray fluorescence (XRF). The new scale dissolver was prepared in different concentrations to examine its dissolution efficiency for the scale with time at low temperatures. The experimental design studied the solid to fluid ratio, temperature, solubility time, and dissolution efficiency in order to achieve the optimum and most economic performance of solubility in terms of high dissolution efficiency with the smallest possible amount of scale dissolver. A solubility comparison was performed with other commercial-scale-dissolvers and the corrosion rate was tested. The experimental work results demonstrated the superior performance of the new scale dissolver. The new scale dissolver showed a solubility efficiency of 91.8% at a low temperature of 45 °C and 79% at 35 °C. The new scale dissolver showed a higher solubility ratio for the scale sample than the ethylenediaminetetraacetic acid (EDTA) (20 wt. %), diethylenetriamine pentaacetic acid (DTPA) (20 wt. %), and HCl (10 wt. %). The corrosion rate for the new non-corrosive dissolver was 0.01357 kg/m2 (0.00278 lb./ft²) which was considered a very low rate and non-damaging for the equipment. The low corrosive effect of the new dissolver will save the extra cost of adding the corrosion inhibitors and save the equipment from the damaging effect of the corrosive acids.
ChemInform Abstract: Sequential Mono‐N‐arylation of Piperazine Nitrogens. Part 1. A Simplified Method and Its Application to the Preparation of a Key N,N′‐Biaryl Piperazine Antifungal Intermediate. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Voltage regulator module noise analysis for high-volume server applications (2006)

This paper presents a methodology to analyze voltage regulator module (VRM) noise coupling problems in high-volume server applications. The technique is applied on a real engineering design. The comprehensive model includes irregular power shapes, decoupling capacitors, and dielectric and conductive loss. Irregular shaped power plane modeling is cross-checked with four separate methods to demonstrate accuracy.
Pseudospin-1 Physics of Photonic Crystals (2019)

We review some recent progress in the exploration of pseudospin-1 physics using dielectric photonic crystals (PCs). We show some physical implications of the PCs exhibiting an accidental degeneracy induced conical dispersion at the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="normal">Γ</mml:mi></mml:mrow></mml:math> point, such as the realization of zero refractive index medium and the zero Berry phase of a loop around the nodal point. The photonic states of such PCs near the Dirac-like point can be described by an effective spin-orbit Hamiltonian of pseudospin-1. The wave propagation in the positive, negative, and zero index media can be unified within a framework of pseudospin-1 description. A scale change in PCs results in a rigid band shift of the Dirac-like cone, allowing for the manipulation of waves in pseudospin-1 systems in much the same way as applying a gate voltage in pseudospin-1/2 graphene. The transport of waves in pseudospin-1 systems exhibits many interesting phenomena, including super Klein tunneling, robust supercollimation, and unconventional Anderson localization. The transport properties of pseudospin-1 systems are distinct from their counterparts in pseudospin-1/2 systems, which will also be presented for comparison.
Microwave artificially structured periodic media microfluidic sensor (2011)

In this paper, microstrip-based spiral structured artificial magnetic media (metamaterial) coupled with microfluidic channel is experimentally demonstrated for sensing applications. It is found that the resonant frequency and the amplitude changes due to dielectric loading from the introduction of chemical substances in the microfluidic channels. Different concentrations of water - methanol and water - isopropanol samples are used in the characterization of the sensor. For water - methanol mixtures, the resonant frequency shifts from 2.15 GHz to 2.0 GHz with change in dielectric constant from 25 to 75. Results show that the wave propagation in LH-media can be used for interrogation of minute volumes of samples with high sensitivity.
Prostasin Is a Glycosylphosphatidylinositol-anchored Active Serine Protease (2001)

A recombinant human prostasin serine protease was expressed in several human cell lines. Subcellular fractionation showed that this serine protease is synthesized as a membrane-bound protein while a free-form prostasin is secreted into the culture medium. Prostasin was identified in nuclear and membrane fractions. Membrane-bound prostasin can be released by phosphatidylinositol-specific phospholipase C treatment, or labeled by [(3)H]ethanolamine, indicating a glycosylphosphatidylinositol anchorage. A prostasin-binding protein was identified in mouse and human seminal vesicle fluid. Both the secreted and the membrane-bound prostasin were able to form a covalently linked 82-kDa complex when incubated with seminal vesicle fluid. The complex formation between prostasin and the prostasin-binding protein was inhibited by a prostasin antibody, heparin, and serine protease inhibitors. Prostasin's serine protease activity was inhibited when bound to the prostasin-binding protein in mouse seminal vesicle fluid. This study indicates that prostasin is an active serine protease in its membrane-bound form.
Enhanced Production of Fatty Acid Ethyl Ester with Engineered fabHDG Operon in Escherichia coli (2019)

Biodiesel, or fatty acid ethyl ester (FAEE), is an environmentally safe, next-generation biofuel. Conventionally, FAEE is produced by the conversion of oil/fats, obtained from plants, animals, and microorganisms, by transesterification. Recently, metabolic engineering of bacteria for ready-to-use biodiesel was developed. In <i>Escherichia coli</i>, it is produced by fatty acyl-carrier proteins and ethanol, with the help of thioesterase (TesB) and wax synthase (WS) enzymes. One of the foremost barriers in microbial FAEE production is the feedback inhibition of the fatty acid (FA) operon (<i>fabHDG)</i>. Here, we studied the effect of biodiesel biosynthesis in <i>E. coli</i> with an engineered <i>fabHDG</i> operon. With a basic FAEE producing BD1 strain harboring <i>tes</i> and <i>ws</i> genes, biodiesel of 32 mg/L were produced. Optimal FAEE biosynthesis was achieved in the BD2 strain that carries an overexpressed operon (<i>fabH, fabD,</i> and <i>fabG</i> genes) and achieved up to 1291 mg/L of biodiesel, a 40-fold rise compared to the BD1 strain. The composition of FAEE obtained from the BD2 strain was 65% (C10:C2, decanoic acid ethyl ester) and 35% (C12:C2, dodecanoic acid ethyl ester). Our findings indicate that overexpression of the native FA operon, along with FAEE biosynthesis enzymes, improved biodiesel biosynthesis in <i>E. coli</i>.
Loop Heat Pipe Applications for Thermal Control of Martian Landers/Rovers (1999)

In early nineties Mars was designated as the planet to be explored. The present results of Mars program include the following: Background of Mars program. Thermal control design for Martian spacecraft. Loop heat pipe for Lander and Rover. Test results. and LHP applications for future Martian Lander and Rover.
Inhalation Bronchography Using Powdered Calcium loglycamic Acid (1979)

In 16 baboons, reproducible bronchograms could be achieved by inhalation of 400--800 mg of powdered calcium ioglycamic acid. Anesthesia, tracheal intubation, or premedication were not necessary. In patients and volunteers, the inhalation of the contrast medium dust caused strong cough. Local anesthesia allowed inhalation for about 10 minutes, which resulted in successful demonstration of the pharynx, larynx, and trachea with bifurcation. Lobular and segmental bronchi were demonstrated only after a longer inhalation time. The contrast medium was completely eliminated and did not cause any recognizable adverse reaction. Nonspecific inflammatory reaction of the bronchial mucosa was seen microscopically in baboons.
Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4. (1990)

cDNA clones representing the VP4 gene of symptomatic human rotavirus strain KU (VP7 serotype 1) or DS-1 (VP7 serotype 2) or asymptomatic human rotavirus strain 1076 (VP7 serotype 2) were constructed and inserted into a baculovirus expression vector under the control of the polyhedrin promoter. The resulting recombinants expressed the appropriate authentic VP4 rotavirus outer capsid protein. Guinea pigs immunized with these VP4 proteins developed antibodies that neutralized infectivity of the rotavirus from which the immunizing VP4 was derived. These antisera were then used in neutralization tests to define the extent and distribution of VP4 antigenic polymorphism among human rotaviruses. Three distinct serotypes and one subtype of the VP4 outer capsid protein were identified among 17 human rotavirus strains that had previously been assigned to five distinct VP7 serotypes. For the most part, VP4 serotype segregated independently of VP7 serotype. Ten strains of human rotavirus that were associated with symptomatic infection and that exhibited VP7 serotype 1, 3, 4, or 9 specificity, each possessed a VP4 of the same serotype and subtype, designated VP4 serotype 1A. Both symptomatic human rotavirus strains with VP7 serotype 2 specificity were related by neutralization to the VP4 serotype 1A strains and were classified as a subtype of VP4 serotype 1--i.e., serotype 1B--since viruses of serotype 1A appeared to be prime strains. Four human rotavirus strains that were recovered from healthy infants in newborn nurseries in which virus transmission persisted over a long interval, belonged to VP7 serotype 1, 2, 3, or 4, but each strain possessed the same VP4 antigenic specificity that was designated VP4 serotype 2. Finally, a single strain of symptomatic human rotavirus of VP7 serotype 1 specificity possessed a unique VP4 that was provisionally classified as VP4 serotype 3 but this remains to be confirmed because neutralization tests were performed in only one direction. Among the 10 rotavirus strains whose VP4 gene was previously sequenced, there was complete concordance between assignment of VP4 serotype by neutralization and classification according to VP4 amino acid homology. Thus, rotaviruses that exhibited a VP4 amino acid homology of 89% or greater belonged to the same VP4 serotype and subtype as determined by neutralization. Finally, evidence was obtained that the serotype-specific domain is located on the VP8 subunit of VP4.
Device for rapid sample insertion and extraction in thermal chemical vapor deposition tube furnace (2004)

In this article, a simple and inexpensive device to allow the rapid insertion and withdrawal of samples from a tube furnace is described. The device operates in an atmosphere that is separate from ambient. This device shortens sample insertion and extraction times, which allows the study of the short time kinetics of chemical vapor deposition processes, and may allow for the growth of structures that could not be achieved using the conventional sample insertion and extraction procedure. The use of magnets to provide actuation through the walls of a quartz tube furnace is entirely general to any procedure using a tube furnace.
MonteFloor: Extending MCTS for Reconstructing Accurate Large-Scale Floor Plans (2021)

We propose a novel method for reconstructing floor plans from noisy 3D point clouds. Our main contribution is a principled approach that relies on the Monte Carlo Tree Search (MCTS) algorithm to maximize a suitable objective function efficiently despite the complexity of the problem. Like previous work, we first project the input point cloud to a top view to create a density map and extract room proposals from it. Our method selects and optimizes the polygonal shapes of these room proposals jointly to fit the density map and outputs an accurate vectorized floor map even for large complex scenes. To do this, we adapt MCTS, an algorithm originally designed to learn to play games, to select the room proposals by maximizing an objective function combining the fitness with the density map as predicted by a deep network and regularizing terms on the room shapes. We also introduce a refinement step to MCTS that adjusts the shape of the room proposals. For this step, we propose a novel differentiable method for rendering the polygonal shapes of these proposals. We evaluate our method on the recent and challenging Structured3D and Floor-SP datasets and show a significant improvement over the state-of-the-art, without imposing any hard constraints nor assumptions on the floor plan configurations.