gebhart/patrepeval huggingface dataset:
Synthesis of N-Phosphonamidothionate Derivatives of Glutamic Acid (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of N-Phosphonamidothionate Derivatives of Glutamic AcidHaiyan Lu, Karyn L. Mlodnosky, Trang T. Dinh, Azar Dastgah, Vinh Q. Lam, and Clifford E. BerkmanView Author Information Department of Chemistry & Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132 Cite this: J. Org. Chem. 1999, 64, 23, 8698–8701Publication Date (Web):October 15, 1999Publication History Received7 July 1999Published online15 October 1999Published inissue 1 November 1999https://pubs.acs.org/doi/10.1021/jo991090xhttps://doi.org/10.1021/jo991090xbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views199Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Inhibitors,Organic compounds,Peptides and proteins,Phosphorus,Protective groups Get e-Alerts
High electrocatalytic activity of tethered multicopper oxidase–carbon nanotube conjugates (2010)

Multicopper oxidases linked to multiwall carbon nanotubes via the molecular tethering reagent, 1-pyrenebutanoic acid, succinimidyl ester, displayed high bioelectrocatalytic activity for oxygen reduction.
Mapping of the VP40-Binding Regions of the Nucleoprotein of Ebola Virus (2007)

Expression of Ebola virus nucleoprotein (NP) in mammalian cells leads to the formation of helical structures, which serve as a scaffold for the nucleocapsid. We recently found that NP binding with the matrix protein VP40 is important for nucleocapsid incorporation into virions (T. Noda, H. Ebihara, Y. Muramoto, K. Fujii, A. Takada, H. Sagara, J. H. Kim, H. Kida, H. Feldmann, and Y. Kawaoka, PLoS Pathog. 2:e99, 2006). To identify the region(s) on the NP molecule required for VP40 binding, we examined the interaction of a series of NP deletion mutants with VP40 biochemically and ultrastructurally. We found that both termini of NP (amino acids 2 to 150 and 601 to 739) are essential for its interaction with VP40 and for its incorporation into virus-like particles (VLPs). We also found that the C terminus of NP is important for nucleocapsid incorporation into virions. Of interest is that the formation of NP helices, which involves the N-terminal 450 amino acids of NP, is dispensable for NP incorporation into VLPs. These findings enhance our understanding of Ebola virus assembly and in so doing move us closer to the identification of targets for the development of antiviral compounds to combat Ebola virus infection.
Ligand-independent modulation of GIPR signaling by splice variants (2022)

Abstract Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a potential drug target for metabolic disorders. It works with glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in humans to maintain glucose homeostasis. Unlike the other two receptors, GIPR has at least 7 reported (EMBL-EBI, 2022; NCBI, 2022a, 2022b) splice variants (SVs) with previously undefined functions. To explore their roles in endogenous peptide mediated GIPR signaling, we investigated the outcome of co-expressing each of the four SVs in question with GIPR in terms of ligand binding, cAMP accumulation, G s activation, β-arrestin recruitment and cell surface localization. The effects of these SVs on intracellular cAMP responses modulated by receptor activity-modifying proteins (RAMPs) were also studied. It was found that while SVs of GIPR neither bound to the hormone nor affected its signal transduction per se , they differentially regulated GIPR-mediated cAMP and β-arrestin responses. Specifically, SV1 and SV4 were preferable to G s signaling, SV3 was biased towards β-arrestin recruitment, whereas SV2 was inactive on both pathways. In the presence of RAMPs, only SV1 and SV4 synergized the repressive action of RAMP3 on GIP-elicited cAMP production. The results suggest a new form of signal bias that is constitutive and ligand-independent, thereby expanding our knowledge of biased signaling beyond pharmacological manipulation ( i . e ., ligand specific) as well as constitutive and ligand-dependent ( e . g ., SV1 of the growth hormone-releasing hormone receptor).
Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity (2014)

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.
Theory of beam coupling and pulse shaping of mode-locked laser pulses in a photorefractive crystal (1990)

We describe how optical beams from a mode-locked laser will couple in a photorefractive crystal. We show that the two-beam-coupling gain coefficient is proportional to the square of the electric field correlation of the incoming light pulses. Consequently we show that two-beam-coupling experiments can measure the average coherence length of mode-locked laser pulses. We also describe how the temporal envelopes of the mode-locked optical pulses distort as they couple and propagate through the photorefractive crystal, and we give examples of how pulses can be shaped by using photorefractive coupling.
Inflammatory, Serological and Vascular Determinants of Cardiovascular Disease in Systemic Lupus Erythematosus Patients (2019)

SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.
Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates (2009)

The temporal and spatial control over the delivery of materials such as siRNA into cells remains a significant technical challenge. We demonstrate the pulsed near-infrared (NIR) laser-dependent release of siRNA from coated 40 nm gold nanoshells. Tat-lipid coating mediates the cellular uptake of the nanomaterial at picomolar concentration, while spatiotemporal silencing of a reporter gene (green fluorescence protein) was studied using photomasking. The NIR laser-induced release of siRNA from the nanoshells is found to be power- and time-dependent, through surface-linker bond cleavage, while the escape of the siRNA from endosomes occurs above a critical pulse energy attributed to local heating and cavitation. NIR laser-controlled drug release from functional nanomaterials should facilitate more sophisticated developmental biology and therapeutic studies.
Voxar Puzzle: An Innovative Hardware/Software Computer Vision Game for Children Development (2015)

This paper exposes how we united computervision technology and tangible user interfaces to conceive aninnovative product targeting children audience. Voxar Puzzle isa digital game in which children have to choose a puzzle froma virtual library and assemble it by manipulating physicalblocks. Furthermore, the process used for the development ofthe game platform had innovation in mind. A Blue Oceanstrategy was used to define the functionalities and features ofthe game platform, comparing it with relevant competitors.The final result was a prototype with a professional interfacethat was validated with children from a local public school.
Thermal conductivity measurements of suspended graphene with and without wrinkles by micro-Raman mapping (2012)

The thermal conductivity (κ) of suspended graphene membranes made by chemical vapor deposition (CVD) was measured by micro-Raman mapping. Cracks and wrinkles present in these suspended graphene membranes were identified by micro-Raman mapping, and κ values and their statistics were obtained on membranes free of such imperfections in a single mapping. Based on this new technique, an average κ value of 1875 ± 220 W m(-1) K(-1) at 420 K was measured on 26 suspended graphene membranes that were free of wrinkles, ~27% higher than the average value measured from 12 graphene membranes with wrinkles. These results suggest that the variation in published thermal conductivity values for suspended graphene samples could, at least in part, be due to the presence or absence of wrinkles.
Weakly But Deeply Supervised Occlusion-Reasoned Parametric Road Layouts (2022)

We propose an end-to-end network that takes a single perspective RGB image of a complex road scene as input, to produce occlusion-reasoned layouts in perspective space as well as a parametric bird's-eye-view (BEV) space. In contrast to prior works that require dense supervision such as semantic labels in perspective view, our method only requires human annotations for parametric attributes that are cheaper and less ambiguous to obtain. To solve this challenging task, our design is comprised of modules that incorporate inductive biases to learn occlusion-reasoning, geometric transformation and semantic abstraction, where each module may be supervised by appropriately transforming the parametric annotations. We demonstrate how our design choices and proposed deep supervision help achieve meaningful representations and accurate predictions. We validate our approach on two public datasets, KITTI and NuScenes, to achieve state-of-the-art results with considerably less human supervision.
Současné možnosti antimykotické léčby invazivní kandidózy na jednotkách intenzivní péče (2010)

SUMMARY Hamal P., Raclavský V., Svobodova L., Koukalova D.: Current options for antifungal therapy of invasive candidiasis in intensive careunitsCandidemia and invasive candidiasis are the most frequent mycoses in critically ill patients in intensive care units. Recently, the num-ber of systemic antifungal agents has increased, leading to improved treatment options. Yet these infections remain to be characteri-zed by poor prognosis and high mortality rates. The most important predisposing factors are yeast colonization of the mucosa or skinand damage to the integrity of the host’s natural barriers. Early diagnosis of invasive candidiasis is difficult, since its clinical manifes-tations are not characteristic and the laboratory techniques are time-consuming and not completely reliable. The currently availabletreatments comprise three groups of antifungals: triazoles, polyenes and echinocandins. For its effectiveness, low toxicity and reaso-nable price, fluconazole is the most widespread drug currently used to treat systemic yeast infections. However, despite high t reatmentcosts, echinocandins are becoming the drug of choice. The advantages are a broad spectrum of species, safe administration to pat ientswith kidney and liver damage, minimal drug interactions and fungicidal effects. Candidemia may often be positively influenced b y re-placing an intravenous catheter. Despite earlier controversy, the latest treatment strategies clearly recommend its removal. Althoughantifungal prophylaxis lowers the incidence of invasive candidiasis, it is considered to be useful only if targeted to high-risk groups ofpatients. Empirical treatment of febrile patients not responding to broad-spectrum antibiotic therapy is only effective in wards witha higher incidence of systemic candidiasis, in patients with risk factors and if other causes are reliably excluded.
Evaluation of Surface Sorption Processes Using Spectral Induced Polarization and a 22Na Tracer (2015)

We investigate mechanisms controlling the complex electrical conductivity of a porous media using noninvasive spectral induced polarization (SIP) measurements of a silica gel during a pH dependent surface adsorption experiment. Sorption of sodium on silica gel surfaces was monitored as the pH of a column was equilibrated at 5.0 and then successively raised to 6.5 and 8.0, but the composition of the 0.01 M NaCl solution was otherwise unchanged. SIP measurements show an increase in the imaginary conductivity of the sample (17.82 ± 0.07 μS/cm) in response to the pH change, interpreted as deprotonation of silanol groups on the silica gel surface followed by sorption of sodium cations. Independent measurements of Na(+) accumulation on grain surfaces performed using a radioactive (22)Na tracer support the interpretation of pH-dependent sorption as a dominant process controlling the electrical properties of the silica gel (R(2) = 0.99) and confirms the importance of grain polarization (versus membrane polarization) in influencing SIP measurements of silicate minerals. The number of surface sorption sites estimated by fitting a mechanistic, triple-layer model for the complex conductivity to the SIP data (13.22 × 10(16) sites/m(2)) was 2.8 times larger than that estimated directly by a (22)Na mass balance (5.13 × 10(16) sites/m(2)), suggesting additional contributions to polarization exist.
Prediction of two-dimensional momentumless wake by k-epsilon-gamma model (1995)

The k-e-γ model peformance is extended to resolve the jet/wake anomaly, which is encountered in calculating free shear flows by the standard k-e model. In the k-e-γ model, the relation between the rate of dissipation e and the level of intermittency γ is well incorporated. The model is run to predict the two-dimensional momentumless wake where a jet and a wake coexist. The predictions of the k-e-γ model are compared with those of the k-e model as well as the experiment.
ChemInform Abstract: Stereoselective Epoxidations and Electrophilic Additions to Partial Ergot Alkaloids and Conformationally‐Fixed Styrenes. Experimental and Theoretical Modeling Evidence for the Importance of Torsional Steering as a Stereocontrol Element. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A 1S Direct-Battery-Attach Integrated Buck Voltage Regulator with 5-Stack Thin-Gate 22nm FinFET CMOS Featuring Active Voltage Balancing and Cascaded Self-Turn-ON Drivers (2021)

A 1S direct-battery-attach buck converter with a 5-stack, thin-gate-FinFET power train delivers a peak efficiency of 89.2% for a 3.8V in to 1.8V out, with 10x higher power density (~15A/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), switching at up to 10x higher frequency (40MHz) using 4x-10x lower inductance (10-100nH) than state of the art. Cascaded self-timed drivers and soft-switching low-side drivers minimize complexity in driving 10 individual power switches safely.
An Improved Process for the N-Alkylation of Indoles Using Chiral N-Protected 2-Methylaziridines (2002)

An improved process for the N-alkylation of indoles using N-protected homochiral aziridines has been developed. This procedure allows reduced quantities of homochiral starting material to be used and leads to improved overall yields and operability.
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment (2018)

BACKGROUND: In soldiers with posttraumatic stress disorder (PTSD), symptom provocation was found to induce increased connectivity within the salience network, as measured by functional magnetic resonance imaging (fMRI) and global brain connectivity with global signal regression (GBCr). However, it is unknown whether these GBCr disturbances would normalize following effective PTSD treatment. METHODS: 69 US Army soldiers with (n = 42) and without PTSD (n = 27) completed fMRI at rest and during symptom provocation using subject-specific script imagery. Then, participants with PTSD received 6 weeks (12 sessions) of group cognitive processing therapy (CPT) or present-centered therapy (PCT). At week 8, all participants repeated the fMRI scans. The primary analysis used a region-of-interest approach to determine the effect of treatment on salience GBCr. A secondary analysis was conducted to explore the pattern of GBCr alterations post-treatment in PTSD participants compared to controls. RESULTS: Over the treatment period, PCT significantly reduced salience GBCr (p = .02). Compared to controls, salience GBCr was high pretreatment (PCT, p = .01; CPT, p = .03) and normalized post-PCT (p = .53), but not post-CPT (p = .006). Whole-brain secondary analysis found high GBCr within the central executive network in PTSD participants compared to controls. Post hoc exploratory analyses showed significant increases in executive GBCr following CPT treatment (p = .01). CONCLUSION: The results support previous models relating CPT to central executive network and enhanced cognitive control while unraveling a previously unknown neurobiological mechanism of PCT treatment, demonstrating treatment-specific reduction in salience connectivity during trauma recollection.
Evaluation of different methods for measuring the impedance of Lithium-ion batteries during ageing (2015)

The impedance represents one of the most important performance parameters of the Lithium-ion batteries since it used for power capability calculations, battery pack and system design, cooling system design and also for state-of-health estimation. In the literature, different approaches are presented for measuring the impedance of Lithium-ion batteries and electrochemical impedance spectroscopy and dc current pulses are the most used ones; each of these approaches has its own advantages and drawbacks. The goal of this paper is to investigate which of the most encountered impedance measurement approaches is the most suitable for measuring the impedance of Lithium-ion batteries during ageing.
Crystallization of and preliminary X-ray data for the plasma retinol-binding protein. (1984)

Crystals of the human and rabbit plasma retinol-binding proteins have been grown from solutions of polyethylene glycol 6000 and CdCl2. Two crystal forms have been observed for the human protein, while the rabbit protein has only crystallized in one form which is isomorphous with one of the human serum retinol-binding protein crystals. The crystals differ in their morphologies, but are both in space group P212121 and have similar unit cell sizes (a = 45.9, b = 53.3, c = 72.0 A and a = 45.7, b = 48.7, and c = 76.5 A). The crystals diffract to approximately 2.0 A resolution. In both cases there is 1 molecule/asymmetric unit.
Data from TGFβ Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models (2023)

&lt;div&gt;Abstract&lt;p&gt;The immune infiltrate in colorectal cancer has been correlated with outcome, such that individuals with higher infiltrations of T cells have increased survival independent of the disease stage. For patients with lower immune infiltrates, overall survival is limited. Because the patients with colorectal cancer studied have received conventional cancer therapies, these data may indicate that the pretreatment tumor environment increases the efficacy of treatments such as chemotherapy, surgery, and radiotherapy. This study was designed to test the hypothesis that an improved immune environment in the tumor at the time of treatment will increase the efficacy of radiotherapy. We demonstrate that inhibition of TGFβ using the orally available small-molecule inhibitor SM16 improved the immune environment of tumors in mice and significantly improved the efficacy of subsequent radiotherapy. This effect was not due to changes in radiosensitivity, epithelial–mesenchymal transition, or changes in vascular function in the tumor; rather, this effect was dependent on adaptive immunity and resulted in long-term protective immunity in cured mice. These data demonstrate that immunotherapy is an option to improve the immune status of patients with poor tumor infiltrates and that pretreatment improves the efficacy of radiotherapy. &lt;i&gt;Cancer Immunol Res; 2(10); 1011–22. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Delay and reliability-constrained VNF placement on mobile and volatile 5G infrastructure (2020)

The ongoing research and industrial exploitation of SDN and NFV technologies promise higher flexibility on network automation and infrastructure optimization. Choosing the location of Virtual Network Functions is a central problem in the automation and optimization of the software-defined, virtualization-based next generation of networks such as 5G and beyond. Network services provided for autonomous vehicles, factory automation, e-health and cloud robotics often require strict delay bounds and reliability constraints, which are influenced by the location of its composing Virtual Network Functions. Robots, vehicles and other end-devices provide significant capabilities such as actuators, sensors and local computation which are essential for some services. Moreover, these devices are continuously on the move and might lose network connection or run out of battery power, which further challenge service delivery in this dynamic environment. This work tackles the mobility, and battery restrictions; as well as the temporal aspects and conflicting traits of reliable, low latency service deployment over a volatile network, where mobile compute nodes act as an extension of the cloud and edge computing infrastructure. The problem is formulated as a cost-minimizing Virtual Network Function placement optimization and an efficient heuristic is proposed. The algorithms are extensively evaluated from various aspects by simulation on detailed real-world scenarios.