gebhart/patrepeval huggingface dataset:
[Traumatic rupture of the diaphragm]. (1990)

Traumatic ruptures of the diaphragm occur most frequently at blunt injuries of the abdomen or thorax as a component of polytraumatism. At the acute stage they present a serious diagnostic problem since signs of polytrauma are predominant. The authors report 3 cases of traumatic rupture of the diaphragm with thoracotomy as the therapeutic approach. The first patient presented with severe polytraumatism and shock, rupture of the diaphragm, pericardium and lungs, along with serial fracture of the left ribs. The second patient was not in shock, he had suffered serial fracture of the left ribs and fracture of the pelvis. In both these cases of blunt injury to the thorax, careful examination of the patients resulted in early diagnosis and surgery. The third patient presented with open injury of the right side of the thorax, injured diaphragm and liver, serial fracture of the ribs, fractured sternum, and was in a state of deep shock. There was no mortality, all three patients recovered.
Origin of periodic and chaotic dynamics due to drops moving in a microfluidic loop device (2014)

Droplets moving in a microfluidic loop device exhibit both periodic and chaotic behaviors based on the inlet droplet spacing. We observe that the periodic behavior is an outcome of carrier phase mass conservation principle, which translates into a droplet spacing quantization rule. This rule implies that the summation of exit spacing is equal to an integral multiple of inlet spacing. This principle also enables identification of periodicity in experimental systems with input scatter. We find that the origin of chaotic behavior is through intermittency, which arises when drops enter and leave the junctions at the same time. We derive an analytical expression to estimate the occurrence of these chaotic regions as a function of system parameters. We provide experimental, simulation, and analytical results to validate the origin of periodic and chaotic behavior.
Is the ability to identify deviations in multiple trajectories compromised by amblyopia? (2006)

Amblyopia results in a severe loss of positional information and in the ability to accurately enumerate objects (V. Sharma, D. M. Levi, & S. A. Klein, 2000). In this study, we asked whether amblyopia also disrupts the ability to track a near-threshold change in the trajectory of a single target amongst multiple similar potential targets. In the first experiment, we examined the precision for detecting a deviation in the linear motion trajectory of a dot by measuring deviation thresholds as a function of the number of moving trajectories (T). As in normal observers, we found that in both eyes of amblyopes, threshold increases steeply as T increases from 1 to 4. Surprisingly, for T = 1-4, thresholds were essentially identical in both eyes of the amblyopes and were similar to those of normal observers. In a second experiment, we measured the precision for detecting a deviation in the orientation of a static, bilinear "trajectory" by again measuring deviation thresholds (i.e., angle discrimination) as a function of the number of oriented line "trajectories" (T). Relative to the nonamblyopic eye, amblyopes show a marked threshold elevation for a static target when T = 1. However, thresholds increased with T with approximately the same slope as in their preferred eye and in the eyes of the normal controls. We conclude that while amblyopia disrupts static angle discrimination, amblyopic dynamic deviation detection thresholds are normal or very nearly so.
New approach to the formation of the basic waveguide radiation mode in a high-power slab-type CO 2 laser (2005)

The paper presents a new approach for radiation mode formation, based on the proper choice of the discharge electrode's shape and the distance from the resonator's mirrors to the butt-end of electrodes. In theory and in experiment was shown the possibility to select the basic waveguide mode of radiation. For 2.5 KW slab CO<sub>2</sub> laser, excited at 40,68MHz, was obtained the near diffraction-limited divergence.
A 5GHz Sub-Harmonic Direct Down-Conversion Mixer for Dual-Band System in 0.35μ SiGe BiCMOS (2005)

A 5-6 GHz sub-harmonic mixer for a dual-band direct-down conversion transceiver is presented. The sub-harmonic technique is used to alleviate the self-mixing problem of the zero-IF architecture, which deteriorates the system sensitivity by generating a dynamic DC offset. The mixer adopts a single balanced topology that provides easy connection with single-ended LNA and ensures lower power consumption. Both differential output and single-ended output configuration are used. The design is implemented in a commercial 0.35 /spl mu/m SiGe BiCMOS process and features a differential conversion gain of 0 dB at 50 /spl Omega/ load and 15 dB for high-Z load, an IIP/sub 3/ of +2.7 dBm, and a power consumption of 3.7 mA with 3 V supplies.
Plasma Levels of Soluble Interleukin-2 Receptor α (2015)

These results support a role for sIL-2Rα in atherosclerosis and provide evidence for multiple-associated single-nucleotide polymorphisms at chromosome 10p15-14.
Reverse Engineering and Prevention Techniques for Physical Unclonable Functions Using Side Channels (2014)

This paper investigates and addresses the vulnerabilities of existing physical unclonable functions (PUFs). We first develop a PUF reverse engineering approach by conducting gate-level characterization (GLC). Based on the gate-level delay properties, we emulate the target PUF by designing a functionally equivalent PUF replication. Furthermore, in order to prevent such an attack, we develop a new sequential PUF architecture that is resilient to side channel-based reverse engineering. We obtain accurate results in emulating the timing behavior of the existing arbiter-based PUFs. Also, the randomness obtained from the sequential PUFs is significantly higher compared to the existing PUFs.
Sol‐Gel Entrapped Pyridinium Hydrobromide Perbromide as a Recyclable Bromination Agent: Its Application to a One‐Pot Bromination and Dehydrobromination Process (2006)

Abstract Silica sol‐gel encaged pyridinium hydrobromide perbromide can be used for clean, odorless bromination of a variety of substrates, including alkenes, ketones, and arenes. The used heterogenized bromination reagent can be recharged with bromine and recycled. In the presence of sol‐gel entrapped 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene, dibromides are dehydrobrominated to give vinyl monobromides and/or alkynes. Encapsulation of the pyridinium derivative and the guanidine base within separate sol‐gel matrices enables the use of both opposing reagents in one‐pot reactions without their mutual destroying each other. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2006)
Na Reactivity toward Carbonate-Based Electrolytes: The Effect of FEC as Additive (2016)

Na-ion batteries have regained attention because they offer sustainability advantages over the Li-ion technology, hence their interest for massive electrochemical storage. Although the Na-ion electrochemistry is analogous to that of the Li-ion concept, there are a few notable differences such as the stability of carbonated-based electrolytes toward the Li or Na metal anodes. Herein we report on the positive effect of FEC as electrolyte additive on the efficiency of Na-half cells which unfortunately comes with a side effect involving the sudden onset of polarization during discharge at unpredictable capacity values. We show that these anomalies, associated to an inefficient plating-stripping at the sodium metal anode, do not appear in full Na-ion cells. Therefore, FEC-based electrolytes are not the panacea and alternative additives must be sought to enable building of reliable half cells with metal anodes.
The Structure and Function of Proline Recognition Domains (2003)

One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling.
Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy (2017)

IL-7 therapy has been evaluated in patients who do not regain normal CD4 T cell counts after virologically successful antiretroviral therapy. IL-7 increases total circulating CD4 and CD8 T cell counts; however, its effect on HIV-specific CD8 T cells has not been fully examined. TRAF1, a prosurvival signaling adaptor required for 4-1BB-mediated costimulation, is lost from chronically stimulated virus-specific CD8 T cells with progression of HIV infection in humans and during chronic lymphocytic choriomeningitis infection in mice. Previous results showed that IL-7 can restore TRAF1 expression in virus-specific CD8 T cells in mice, rendering them sensitive to anti-4-1BB agonist therapy. In this article, we show that IL-7 therapy in humans increases the number of circulating HIV-specific CD8 T cells. For a subset of patients, we also observed an increased frequency of TRAF1<sup>+</sup> HIV-specific CD8 T cells 10 wk after completion of IL-7 treatment. IL-7 treatment increased levels of phospho-ribosomal protein S6 in HIV-specific CD8 T cells, suggesting increased activation of the metabolic checkpoint kinase mTORC1. Thus, IL-7 therapy in antiretroviral therapy-treated patients induces sustained changes in the number and phenotype of HIV-specific T cells.
Chemodivergent coupling of azoarenes with benzyl alcohols via a borrowing hydrogen strategy using a well-defined nickel catalyst (2023)

A chemodivergent protocol for the (de)hydrogenative coupling of azoarenes with benzyl alcohol is described via the NN bond activation using an inexpensive and well-defined nickel catalyst.
Re: Intravesical TRPV4 Blockade Reduces Repeated Variate Stress-Induced Bladder Dysfunction by Increasing Bladder Capacity and Decreasing Voiding Frequency in Male Rats (2014)

No AccessJournal of UrologyInvestigative Urology1 Mar 2015Re: Intravesical TRPV4 Blockade Reduces Repeated Variate Stress-Induced Bladder Dysfunction by Increasing Bladder Capacity and Decreasing Voiding Frequency in Male Rats Anthony AtalaMD Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.12.030AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Intravesical TRPV4 Blockade Reduces Repeated Variate Stress-Induced Bladder Dysfunction by Increasing Bladder Capacity and Decreasing Voiding Frequency in Male Rats." The Journal of Urology, 193(3), pp. 1060–1061 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 3March 2015Page: 1060-1061Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF DownloadLoading ...
Persistent luminescence in nanophosphors for long termin-vivobio-imaging (2015)

We presently introduce a novel generation of optical nanoprobes, based on chromium-doped zinc gallate, whose persistent luminescence can be activated<i> in vivo </i>through living tissues using highly penetrating low energy photons from the red region of the visible spectrum. Surface functionalization of this photonic nanoprobe can be adjusted to favor multiple challenging biomedical applications.
Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration (2021)

Abstract Purpose To determine feasibility of plant-derived recombinant human collagen type I (RHCI) for use in corneal regenerative implants Methods RHCI was crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to form hydrogels. Application of shear force to liquid crystalline RHCI aligned the collagen fibrils. Both aligned and random hydrogels were evaluated for mechanical and optical properties, as well as in vitro biocompatibility. Further evaluation was performed in vivo by subcutaneous implantation in rats and corneal implantation in Göttingen minipigs. Results Spontaneous crosslinking of randomly aligned RHCI (rRHCI) formed robust, transparent hydrogels that were sufficient for implantation. Aligning the RHCI (aRHCI) resulted in thicker collagen fibrils forming an opaque hydrogel with insufficient transverse mechanical strength for surgical manipulation. rRHCI showed minimal inflammation when implanted subcutaneously in rats. The corneal implants in minipigs showed that rRHCI hydrogels promoted regeneration of corneal epithelium, stroma, and nerves; some myofibroblasts were seen in the regenerated neo-corneas. Conclusion Plant-derived RHCI was used to fabricate a hydrogel that is transparent, mechanically stable, and biocompatible when grafted as corneal implants in minipigs. Plant-derived collagen is determined to be a safe alternative to allografts, animal collagens, or yeast-derived recombinant human collagen for tissue engineering applications. The main advantage is that unlike donor corneas or yeast-produced collagen, the RHCI supply is potentially unlimited due to the high yields of this production method. Lay Summary A severe shortage of human-donor corneas for transplantation has led scientists to develop synthetic alternatives. Here, recombinant human collagen type I made of tobacco plants through genetic engineering was tested for use in making corneal implants. We made strong, transparent hydrogels that were tested by implanting subcutaneously in rats and in the corneas of minipigs. We showed that the plant collagen was biocompatible and was able to stably regenerate the corneas of minipigs comparable to yeast-produced recombinant collagen that we previously tested in clinical trials. The advantage of the plant collagen is that the supply is potentially limitless.
Effect of piroxicam on gait in patients with osteoarthritis of the knee (1993)

NSAID treatment in patients with knee OA results in a reduction in symptomatic pain and an increase in loading of the knee. Whether the increased loading is due to the analgesic effects of the treatment is unknown, but if so, the development of agents capable of relieving pain while reducing loads at the knee may be desirable.
Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss (2015)

We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.
Influence of boundary conditions on time-reversal focusing through heterogeneous media (1998)

This letter presents a way to overcome ultrasonic focusing degradations through strongly diffracting nondissipative layers. A first set of experiments shows that, using finite aperture transducer arrays, neither the time-reversal technique, nor other focusing techniques are able to achieve proper focusing through this kind of aberrator. These experimental results show the limits of a finite aperture time-reversal mirror compared to the theoretical behavior of a time-reversal cavity. To simulate a time-reversal cavity, totally reflecting walls are set between the time-reversal mirror and the aberrator. The experiments and numerical simulations presented in this letter show that as soon as we introduce these reflecting boundaries, the time-reversal focusing becomes optimal and the spatial resolution is strongly improved.
On Network Performance Indicators for Network Promoter Score Estimation (2019)

Estimation of user perceived quality of offered services, from massive number of Key Performance Indicator (KPI)'s that are measured in diverse components, has been a necessity for mobile network operators. The goal is first to have a good estimator for poor Quality of Experience (QoE), which can potentially be achieved with machine learning, and then pinpoint the features that are contributing to the poor performance. There is often a tradeoff between accuracy and interpretability of models. In this paper, we address this tradeoff by first developing a robust but complex teacher machine learning model to map the subjective Net Promoter Score (NPS) values computed from the user quality feedback to the underlying subset of KPI metrics. Next, we develop a rather interpretable student model supervised by the pre-trained teacher model. Eventually the compact student decision tree model learns to mimic the behavior of the teacher model with an at least 10 % improved accuracy in testset as compared to conventional way of directly training using the decision tree model. In the last step, we extract the rules and important influential features of the distilled student model.
CBC8: A 0.25 &#x00B5;m SiGe-CBiCMOS technology platform on thick-film SOI for high-performance analog and RF IC design (2010)

A production released complementary-SiGe BiCMOS technology on SOI has been developed for high speed analog and RFIC applications. It features matched SiGe:C PNP and NPN transistors. The PNP shows cutting edge performance metrics with β·V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">A</sub> = 17,000 and near record f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ·BVCEO ≥ 195GHz·V for a 5V process while demonstrating best in class linearity on a fully differential amplifier design. A modular process flow was leveraged to enhance the Analog design needs for the platform. For higher-speed lower power, we also demonstrate a low voltage SiGe NPN with peak f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of 50 GHz at low-bias (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE</sub> = 0.5V), ideal for load line drive. Finally, we discuss core CMOS devices which utilize a dual-gate oxide process for improved mixed-signal mixed-voltage design and better optimization of digital blocks.
Rear Door Heat Exchanger Cooling Performance in Telecommunication Data Centers (2010)

The increase in the data center server heat density waves a scope for developing improved cooling technologies without raising the power consumption. It is commonly observed that 40% of the total data center energy is consumed by its cooling equipments. For higher server density cabinets, typical air cooling techniques leads to a substantial increase in the power consumption. Rear door heat exchanger, an open looped cooling technique is one of the solutions for such scenarios. In this paper, emphasis is laid on the analytical determination of the optimum heat load after calculating the effectiveness of heat exchanger at given operating conditions of the data center and heat exchanger. Later, thermal analysis is performed and the working of heat exchanger is compared for different data center heat loads. Based on the results, a ‘rule of thumb’ is verified that rear door heat exchanger could be 100% efficient in cooling the cabinets of heat loads up to 27kW. Thus, for rack heat loads less than 27KW, CRAC units can be non-operational resulting in energy savings. Furthermore, effect of RDHx in different configuration is studied and compared.
Path Diversity with Fractional Delay Transmission for Fractional Sampling-MIMO-OFDM System (2009)

Through fractional sampling (FS) it is possible to separate multipath components and achieve path diversity. However, if no path component whose delay corresponds to the sampling point, FS cannot obtain diversity gain. In this paper, a novel scheme to improve the performance with FS over a sparse multipath channel is proposed. The proposed scheme uses multiple transmit antennas and transmit multiple signals with fractional delays. The performance improvement with the proposed scheme is confirmed through computer simulation. It is shown that the proposed scheme increases the capacity of a MIMO-OFDM system by a factor of 1.5 to 2.
Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway (2016)

Chikungunya virus (CHIKV) has been spreading rapidly, with over one million confirmed or suspected cases in the Americas since late 2013. Infection with CHIKV causes devastating arthritic and arthralgic symptoms. Currently, there is no therapy to treat this disease, and the only medications focus on relief of symptoms. Recently, protein kinase C (PKC) modulators have been reported to inhibit CHIKV-induced cell death in cell assays. The salicylate-derived bryostatin analogues described here are structurally simplified PKC modulators that are more synthetically accessible than the natural product bryostatin 1, a PKC modulator and clinical lead for the treatment of cancer, Alzheimer's disease, and HIV eradication. Evaluation of the anti-CHIKV activity of these salicylate-derived bryostatin analogues in cell culture indicates that they are among the most potent cell-protective agents reported to date. Given that they are more accessible and significantly more active than the parent natural product, they represent new therapeutic leads for controlling CHIKV infection. Significantly, these analogues also provide evidence for the involvement of a PKC-independent pathway. This adds a fundamentally distinct aspect to the importance or involvement of PKC modulation in inhibition of chikungunya virus replication, a topic of recent and growing interest.
Intelligent fractional-order PID (FOPID) heart rate controller for cardiac pacemaker (2016)

Efficient and robust control of cardiac pacemaker is essential for providing life-saving control action to regulate Heart Rate (HR) in a dynamic environment. Several controller designs involving proportional-integral-derivative (PID) and fuzzy logic controllers (FLC) have been reported but each have their limitations to face the dynamic challenge of regulating HR. Fractional-order control (FOC) systems provide controllers that are described by fractional-order differential equations that offers fine tuning of the control parameters to provide robust and efficient performance. In this work a robust fractional-order PID (FOPID) controller is designed based on Ziegler-Nichols tuning method. The stable FOPID controller outperformed PID controllers with different tuning methods and also the FLC in terms of rise time, settling time and % overshoot. The FOPID controller also demonstrated feasibility for rate-adaptive pacing. However, the FOPID controller designed in this work is not optimal and is limited by the tuning procedure. More efficient design using optimization techniques such as particle swarm intelligence or genetic algorithm tuning can offer optimal control of the cardiac pacemaker.