gebhart/patrepeval huggingface dataset:
Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients (2009)

Reconstitution of cytomegalovirus (CMV)-specific CD8(+) T cells is essential to the control of CMV infection in CMV-positive recipients (R(+)) after allogeneic hematopoietic stem cell transplantation (HCT). Six-color flow cytometry was used to assess the functional profile of CMV-specific CD8(+) T cells in 62 of 178 R(+) HCT recipients followed virologically for CMV reactivation. R(+) recipients receiving grafts from CMV-negative donors (D(-); D(-)/R(+)) reconstituted fewer multifunctional CD8(+) T cells expressing tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-1beta (MIP-1beta), and CD107 in addition to interferon-gamma (IFN-gamma), compared with D(+)/R(+) recipients. Unlike monofunctional CD8(+) T cells secreting IFN-gamma, which were abundantly generated during CMV reactivation in D(-)/R(+) recipients, the relative lack of multifunctional CD8(+) T cells persisted until at least 1 year post-HCT. D(-)/R(+) recipients were more likely to require recurrent and prolonged use of antivirals. These findings were robust to statistical adjustment for pretransplant factors, as well as for posttransplant factors including graft-versus-host disease (GVHD) and its treatment by steroids. These analyses suggest that D(+)/R(+) transplants, on average, generate higher levels of multifunctional CMV-specific T cells and require less antiviral therapy compared with D(-)/R(+) HCT recipients. These results highlight the benefit of D(+) donors in improving outcomes of R(+) HCT recipients by reducing the duration and recurrent need of antiviral treatment, aided by increased levels of multifunctional CMV-specific T cells.
Evaluation Of A Dissolvable Ureteral Drainage Stent In A Swine Model (2002)

These temporary drainage stents appeared to dissolve in benign fashion, as evidenced by the appearance of the collecting system on excretory urography and by histological changes. In addition, inflammatory changes throughout the urinary tract were similar for each stent evaluated. Further analysis is warranted in human subjects to assess the exact time of stent retention, potential adverse symptoms, stent fragment passage and safety.
Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor (2020)

Tubastatin A, a tetrahydro-γ-carboline-capped selective HDAC6 inhibitor (HDAC6i), was rationally designed 10 years ago, and has become the best investigated HDAC6i to date. It shows efficacy in various neurological disease animal models, as HDAC6 plays a crucial regulatory role in axonal transport deficits, protein aggregation, as well as oxidative stress. In this work, we provide new insights into this HDAC6i by investigating the molecular basis of its interactions with HDAC6 through X-ray crystallography, determining its functional capability to elevate the levels of acetylated α-tubulin in vitro and in vivo, correlating PK/PD profiles to determine effective doses in plasma and brain, and finally assessing its therapeutic potential toward psychiatric diseases through use of the SmartCube screening platform.
ChemInform Abstract: ASYMMETRIC SYNTHESES VIA HETEROCYCLIC INTERMEDIATES. XV. ENANTIOSELECTIVE SYNTHESIS OF (R)-(-)-β-HYDROXYVALINE USING L-VALINE OR (S)-O,O-DIMETHYL-α-METHYLDOPA AS CHIRAL AUXILIARY REAGENTS (1983)

Die chiralen Dihydropyrazin-Derivate (I) und (V) werden durch Metallierung und Addition an Aceton in Carbinole (II) bzw. (VI) umgewandelt, aus denen nach Hydrolyse (RHS-Hydroxyvalin (IV) erhalten wird.
Color Doppler Sonographic Evaluation of Peak Systolic Velocity and Pulsatility Index in Artery after Pulsed HIFU Exposure (2011)

The objective of current study was to investigate the functional changes in arteries induced by pulsed‐HIFU with or without microbubbles. Sonication was applied at an ultrasound frequency of 1 MHz with a burst length of 50 ms and a repetition frequency of 1 Hz. The duration of the whole sonication was 6s. The abdominal aortas of Sprague‐Dawley rats were surgically exposed and sonicated with pulsed HIFU; the pulsed HIFU beam was aimed using color images of the blood flow. There was no obvious normalized peak systolic velocity (PSV) change at various acoustic powers of pulsed‐HIFU exposure in the absence of ultrasound contrast agent (UCA). However, the normalized PSV change induced by pulsed‐HIFU decreased with the injected dose of UCA at acoustic powers. At this time, the normalized pulsatility index (PI) change in the vessel subjected to pulsed‐HIFU increased in proportion to UCA dose. Additional research is needed to investigate the detailed mechanical effects of pulsed‐HIFU exposure on blood flow and the structure of vessel walls.
Pre-compensation for the effects of cascaded optical filtering on 10 Gsymbol/s DPSK and DQPSK signals (2009)

The effects of cascaded optical filtering on 10 Gsymbol/s DPSK and DQPSK signals are mitigated by pre-compensation based on the use of digital signal processing to generate the drive signals for a dual-parallel Mach-Zehnder modulator.
CEBPA Methylation and Notch1 Mutations Are Common in Immature T-ALLs but Not M0 AML and Cosegregate with TCRG Rearrangement and the TCRgd Lineage. (2007)

Abstract The CEBPA gene codes for the C/EBPa transcription factor which regulates hematopoietic stem cell homeostasis and orientates towards myeloid differentiation and against a T lymphoid fate. CEBPA silencing by promoter hypermethylation (CEBPAmeth) has recently been identified (Wouters, Blood 2007) in a minor subset of AML, all of which demonstrated T lymphoid features (expression of CD7 and CD3 transcripts, TCRG rearrangement and frequent NOTCH1 mutations (NOTCH1m)). These AML may be closer to immature T-ALLs, with CEBPa silencing and NOTCH1m determining lineage orientation. Although expression of CD7 and cytoplasmic CD3 (cCD3) are considered as defining markers in T-ALL, CD7 is commonly expressed in AML and reproducible multicenter detection of low level cCD3, when performed, can be difficult. We have classified CD7+, cCD3+ T-ALLs on the basis of their TCR profiles: immature cases arrested prior to TCRB VDJ rearrangement include TCRgd lineage precursors and can be divided into those with no TCR rearrangement (IM0), TCRd only rearrangement (IMD) or TCRd and TCRg rearrangement (IMG). The CALM-AF10 fusion transcript is found in both AML and T-ALL, where it is restricted to the TCRgd lineage. We initially searched for in CEBPAmeth by methylation specific PCR in 5 AML with downregulated CEBPand confirmed that the 3 cases (FAB-M0/M1) with CEBPAmeth expressed CD3, CD7 and/or TCRg rearrangement. Only 1/49 AML M0, all of which were cCD3 negative, demonstrated CEBPAmeth.We then searched for CEBPAmeth and mutation and NOTCH1m in 18 IM T-ALL (4 aged &lt;15y; 5 IM0, 5 IMD, 8 IMG) compared to 6 adults with TCRB VDJ+, TCRab lineage T-ALL. No CEBPA mutations were found but 11/24 (56%) demonstrated CEBPAm and 10/23 (43%) NOTCH1m. Both correlated with IMG T-ALL, when 6/8 demonstrated CEBPAmeth and NOTCH1m and a seventh only NOTCH1m, compared to only 4/10 CEBPAmeth and 1/10 NOTCH1m in IM0/D cases, with no overlap. In ab-lineage T-ALLs 2/6 demonstrated NOTCH1m, one of which was also CEBPAmeth, and notably expressed TLX1/HOX11. CEBPAmeth cases were more frequently CALM-AF10+ (5/10), CD2-, CD123/IL3R-, HOXA9 transcript+ and IgH DJ rearranged but did not differ from non-CEBPAmeth T-ALL in CD34, CD5, CD117, CD13/33, CD79a or CD56 expression. As such CEBPAmeth is rare in cCD3- M0 AML but common in cCD3+ immature T-ALL, independently of myeloid antigen expression. CEBPAmeth and NOTCH1m in IM T-ALL are preferentially associated with cases having undergone TCRG rearrangement but are not found in the majority of more immature cases, demonstrating that CEBPAmeth is not necessary for CD7 and cCD3 expression, within a T-ALL context. It also suggests that CALM-AF10 should be searched for in CEBPAmeth AML, raises issues regarding AML vs. ALL protocol assignement and the use of demethylating agents in IMG T-ALLs and suggests that the potentially misleading “biphenotypic leukaemia” label be reassessed.
ChemInform Abstract: (E)‐3‐(TRIMETHYLSILYL)‐2‐PROPEN‐1‐OL. AN IMPROVED PREPARATION (1983)

Abstract Propargylalkohol (I) wird über die Grignardverbindung zu (II) silyliert und dann der Reduktion mit Lithiumalanaten unterworfen, wobei je nach den Reaktionsbedingungen unterschiedliche Anteile an den isomeren Trimethylsilylpropenolen (III) und (IV) bzw. auch das gesättigte 3‐Trimethylsilyl‐1‐propanol (V) erhalten werden.
Imaging beyond aliasing (2016)

A sufficiently high spatial sampling is critical for high quality imaging. If the sampling criterion is not met, artifacts appear in the image generally referred to as grating lobes. Probes with a large aperture provide a large field of view, which allows for more efficient inspection. On the other hand this leads to an increase in the number of element to obey the sampling criterion. We have developed a method that reconstructs sparsely sampled data without assuming anything about the medium. The reconstruction method involves an iterative scheme using wave field extrapolation. After the reconstruction an aliasing free dataset is obtained which can be imaged properly. Aliased and non-aliased datasets were modeled based on point diffractors and reflectors with an increasing width. The datasets were imaged using a mapping in the wavenumber-frequency domain. Up to a factor four of under-sampling can be tolerated, providing the same image quality as a properly sampled dataset.
High-power laser arrays with 100% fill factor emission facet - art. no. 69091B 39 (2008)

Novel types of laser diode array with a 100% filling factor at the emission facet are reported. The arrays utilize both parallel and tapered cavity emitters that are connected via a common Laterally Unconfined Non-Absorbing Mirror (LUNAM) defined with quantum-well intermixing technology at 808 nm wavelength. Two LUNAM array types are considered: incoherent (weakly coupled) and coherent (diffraction coupled). Incoherent LUNAM arrays benefit from a reduced power density at the facet, improving reliability, and a near-uniform intensity distribution across the array aperture. Stacked laser diode arrays built with LUNAM bars deliver 950 W power under QCW operation with &amp;lt;5% degradation at 1.9 x 10(8) shots. Novel coherent arrays are realized using a monolithically integrated LUNAM Talbot cavity. The devices produce a single-lobed horizontal far-field pattern over a limited current range with &amp;lt;10% slope efficiency penalty compared to an uncoupled case. The LUNAM arrays are promising candidates for high-power, high-brightness and high-reliability operation
Neural Networks as Surrogates of Nonlinear High-Dimensional Parameter-to-Prediction Maps (2018)

We present a preliminary investigation of the use of Multi-Layer Perceptrons (MLP) and Recurrent Neural Networks (RNNs) as surrogates of parameter-to-prediction maps of com- putational expensive dynamical models. In particular, we target the approximation of Quan- tities of Interest (QoIs) derived from the solution of a Partial Differential Equations (PDEs) at different time instants. In order to limit the scope of our study while targeting a rele- vant application, we focus on the problem of computing variations in the ice sheets mass (our QoI), which is a proxy for global mean sea-level changes. We present a number of neural network formulations and compare their performance with that of Polynomial Chaos Expansions (PCE) constructed on the same data.
Calibration of Lead-Line Response Contribution in Measured Radiation Patterns of IR Dipole Arrays (2010)

A bolometer, which is in the shape of an antenna, is investigated as an infrared detector. Similar to antenna-coupled bolometers, this device can be designed to meet specific spectral, polarization, and directional criteria. The fabricated device is not an isolated antenna; it contains lead lines for biasing and signal extraction, which also respond to the incident radiation and contribute to the measured response. An additional device is designed to measure this response component, which is then removed from the measured response of the device containing the antenna. The measured radiation patterns without lead-line contributions show excellent agreement with the simulated patterns.
Interactions of thyroid hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat liver mRNA species (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteractions of thyroid hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat liver mRNA speciesChen Liaw, Steven Seelig, Cary N. Mariash, Jack H. Oppenheimer, and Howard C. TowleCite this: Biochemistry 1983, 22, 1, 213–221Publication Date (Print):January 4, 1983Publication History Published online1 May 2002Published inissue 4 January 1983https://pubs.acs.org/doi/10.1021/bi00270a031https://doi.org/10.1021/bi00270a031research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient solvent-free cationization of alkylpolyglycoside based surfactant compositions using natural glycine betaine (2015)

Solvent-free transformation of alkylpolyglycosides into 100% bio-based cationic sugar surfactants proceeded efficiently using a natural glycine betaine-derived cationizing agent.
Novel Expandable Cement System for Prevention of Sustained Casing Pressure and Minimization of Lost Circulation (2021)

Sustained casing pressure (SCP) is a common issue in the oil and gas industry. There were several solutions applied to contain it either by mechanical means or by injecting high-performing cement slurries. There are some limitations associated with these solutions such as volume loss, mechanical failures, limited expansion, exact spotting, and material deterioration with time. In this study, a novel expandable cement system contains a novel silicate aqueous alkali alumino silicate (AAAS) and zinc (Zn) metal slurry, and class G cement is introduced as an expandable solution to prevent annulus flow between the casing and formation. The silicate-based admixture reacts with the Zn metal slurry to generate hydrogen gas that results in the expansion of the cement slurry. The reaction and expansion can be controlled by optimizing the quantities of silicate systems and metal slurry. The expansive properties of the silicate system can be utilized to formulate a cement mix for plugging off the annulus flow. Cement slurries with different percentages such as 3, 5, and 8% by weight of water (BWOW) of AAAS silicate and Zn metal slurry were prepared and tested for their expansion. Several laboratory tests such as expansion, consistency, viscosity, and unconfined compressive strength were performed to assess the percentage expansion. The expansion was tested in the plastic tube as well as in expansion molds. The cement slurries were cured at 50 °C temperature in a water bath. It was observed that metal slurry upon reaction with AAAS silicate resulted in cement expansion by several percentages. The cement expansion was reduced by 16% at 8% BWOW concentration of AAAS silicate as compared to the expansion gained at 3% BWOW concentration. Further, the temperature triggers the expansion of cement slurry. The consistency and viscosity were impacted by the addition of AAAS and metal slurry. The application of expandable slurry can help in preventing the annulus flow and eliminating the safety issues associated with SCP. The expansion solution can be applied in loss circulation zones.
2013 IEEE Symposium on Visual Languages and Human Centric Computing (2013)

It was our pleasure to welcome you to the 2016 IEEE Symposium on Visual Languages and Human-Centric Computing, held at the University of Cambridge, UK.For 2016, the conference had a special theme, on which submissions were particularly encouraged: Tools and Techniques for Early Stage Problem Formulation.For VL/HCC 2016 we have assembled an excellent technical program, and the colocation with Psychology of Programming (PPIG) 2016 offered even more opportunities to attend high-quality research presentations.
Automatic recording method for holographic three-dimensional animation (1992)

We propose a new method for the automatic printing of holographic three-dimensional (3-D) animation viewed under white-light illumination. One can display the animated 3-D image near the hologram plane by vertically scrolling the hologram. Since the hologram consists of small elemental holograms that are individually recorded at multiple exposures, the image size and the playback length are not restricted by the size of the recording optical system. A 3-D animation of 25 frames is experimentally recorded. Clear 3-D images can be observed by pulsed-light illumination.
Disjoint combinations profiling (DCP): a new method for the prediction of antibody CDR conformation from sequence (2014)

The accurate prediction of the conformation of Complementarity-Determining Regions (CDRs) is important in modelling antibodies for protein engineering applications. Specifically, the Canonical paradigm has proved successful in predicting the CDR conformation in antibody variable regions. It relies on canonical templates which detail allowed residues at key positions in the variable region framework or in the CDR itself for 5 of the 6 CDRs. While no templates have as yet been defined for the hypervariable CDR-H3, instead, reliable sequence rules have been devised for predicting the base of the CDR-H3 loop. Here a new method termed Disjoint Combinations Profiling (DCP) is presented, which contributes a considerable advance in the prediction of CDR conformations. This novel method is explained and compared with canonical templates and sequence rules in a 3-way blind prediction. DCP achieved 93% accuracy over 951 blind predictions and showed an improvement in cumulative accuracy compared to predictions with canonical templates or sequence rules. In addition to its overall improvement in prediction accuracy, it is suggested that DCP is open to better implementations in the future and that it can improve as more antibody structures are deposited in the databank. In contrast, it is argued that canonical templates and sequence rules may have reached their peak.
Velocity Gap Theory Developed for Magnifying Resolutions without Changing Separation Mechanisms or Separation Lengths (2009)

Separation techniques, such as chromatography and electrophoresis, form the basis in many fields and are continually developed for better separation efficiency. The efforts normally involve a new mechanism together with sufficient separation length. We develop a velocity gap theory to make things simple. The theory is based on the discovery that the velocity gap (VG) effect could enlarge the distance between two moving objects. Mathematical deduction certified that the resolution may be magnified infinitely without changing the separation mechanism or the separation length. DNA separation confirmed its practical feasibility by achieving 2-5 times higher resolution on a microchip. Our results indicate that VG effect could enlarge the distance between two moving objects and may potentially be utilized to ameliorate separation efficiency.
Electro-Deposition and Dissolution of MnO2on a Graphene Composite Electrode for Its Utilization in an Aqueous Based Hybrid Supercapacitor (2012)

The electro-deposition and dissolution of MnO2 is studied for its potential utilization in hybrid supercapacitors. A commercially available graphene powder is used as high surface area substrate and capacitive type electrode. An aqueous electrolyte composed of 0.5 M H2SO4 + 0.5 M MnSO4 is used. The deposition-dissolution reaction of MnO2 is shown to provide the bulk of the charge storable in the battery type electrode. Furthermore, the potential window of stability of this electrode reaction is compatible with the aqueous electrolyte. Two complete systems were assembled and tested for their charge/discharge behavior. It is shown that energy and power densities of 25 Wh kg-1 and 980 W kg -1, respectively, can be achieved for at least 5000 cycles. Limitations of the system in terms of cycle numbers and electrolyte volume are discussed in more detail. The electrolyte volume to electrode mass ratio is shown to be a critical factor in determining the charge/discharge cycle number of the device. This is believed to be due to the fact that the efficiency of the MnO2 electro-dissolution/deposition process is less than 100%. This, in turn, could result in gradual pH changes and a lower Mn2+ concentration in the electrolyte during continues charging and discharging. This eventually results in lowering the energy and power density of the system. However, it is shown that an energy density of 25 Wh kg-1 is achievable, thus being comparable with similar hybrid systems. © 2012 The Electrochemical Society. All right reserved.
Current Distribution Measurement of YBCO Thin Film for Superconducting Fault Current Limiter. (2002)

Current distribution in the superconducting film for a resistive fault current limiter is important because it influences AC loss and a uniformity of S/N transition. The lateral current distribution of the film was reconstructed from the magnetic field distribution, which is measured by multiple Hall probes. The following results were obtained. (1) Non-uniform current distribution in the superconducting film was observed when the current was less than 1.3times critical current (Ic). (2) The current in a superconducting film was uniform when the current was much higher than Ic. The current can be considered uniform when the film works as a fault current limiter because the S/N transition starts at about twice Ic. (3) The validity of the measurement was verified by the comparison with the electric circuit simulation.
Control Architecture Modeling using Functional Energetic Method - Demonstration on a Hybrid Electric Vehicle (2017)

International audience
Gene copy number variation in pediatric mental illness in a general population (2022)

Abstract We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognitive biomarkers in a community sample of 7,100 unrelated European, and East Asian children and youth (Spit for Science). Diagnoses of mental health disorders were found in 17.5% of participants and 27.6% scored in the highest 10% on either or both ADHD and OCD trait measures. Clinically relevant CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of ADHD ( p =5.0×10 −3 ), on a cognitive biomarker of mental health (response inhibition ( p =1.0×10 −2 )), and on prevalence of mental disorders ( p =1.9×10 −6 , odds ratio: 3.09). With a rise of mental illness, our data establishes a baseline for delineating genetic contributors in paediatric-onset conditions. One Sentence Summary Copy number variation predicts neurodevelopmental and mental health phenotypes in the general population.