gebhart/patrepeval huggingface dataset:
Novel Bidirectional Universal 1-Phase/3-Phase-Input Unity Power Factor Differential AC/DC Converter (2023)

A common 400V dc bus for industrial motor drives advantageously allows the use of high-performance 600V power semiconductor technology in the inverter drive converter stages and to lower the rated power of the supplying rectifier system. Ideally, this supplying rectifier system features unity power factor operation, bidirectional power flow and nominal power operation in the three-phase and the single-phase grid. This paper introduces a novel bidirectional universal single-/three-phase-input unity power factor differential ac-dc converter suitable for the above mentioned requirements: The basic operating principle and conduction states of the proposed topology are derived and discussed in detail. Then, the main power component voltage and current stresses are determined and simulation results in PLECS are provided. The concept is verified by means of experimental measurements conducted in both three-phase and single-phase operation with a 6kW prototype system employing a switching frequency of 100 kHz and 1200V SiC power semiconductors.
Comparison of Total Nutrient Admixture Stability Using Two Intravenous Fat Emulsions, Soyacal and Intralipid 20% (1986)

The safe clinical use and physical stability of a total nutrient admixture (TNA) system containing a soybean oil emulsion (Intralipid) has been reported. A study was conducted to compare the physical stability of four admixtures which were divided into two groups based upon the ratios (1:1:1 and 2:1:1) of amino acids (8.5%), dextrose (70%), and fat emulsion (20%). The fat component in each group contained either a new soy bean fat emulsion, Soyacal, or Intralipid. The quantities of all electrolytes, trace elements and vitamin additives were the same. All solutions were stored at 4 degrees C for 28 days and then held at ambient temperature for 5 days for a total 33-day study period. Each admixture was serially analyzed on days 0, 1, 2, 3, 5, 7, 14, 21, 28, 29, 30, 31, 32, and 33. Examination of gross visual appearance and determinations of pH were performed. Osmolality was measured by means of freezing point depression (Advanced Digimatic Osmometer, Advanced Instruments, Inc., Needham Heights, MA). A Brookhaven particle analyzer was used to measure lipid particle size and particle size distribution. Electron and light microscopy were used to verify maximum particle size and distribution on days 0, 7, 14, 21, 28, and 29. The type of lipid emulsion used did not affect the pH or osmolality of the admixtures. Admixtures prepared with the 2:1:1 ratio had slightly higher pH (0.07) and lower osmolality (350 mOsm/kg). The range of mean diameters for the admixtures prepared with Soyacal and Intralipid were 0.283 to 0.310 micron and 0.314 to 0.351 micron, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Biofuel production by recombinant microorganisms (2023)

Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.
ChemInform Abstract: EFFICIENT SYNTHESES OF BARRELENE AND NENITZESCU′S HYDROCARBON (1976)

Abstract Efficient Syntheses of Barrelene and Nenitzescu′s Hydrocarbon.
Momentum-based reactive stepping controller on level and non-level ground for humanoid robot push recovery (2011)

This paper presents a momentum-based reactive stepping controller for humanoid robot push recovery. By properly regulating combinations of linear and angular momenta, the controller can selectively encourage the robot to recover its balance with or without taking a step. A reference stepping location is computed by modeling the humanoid as a passive rimless wheel with two spokes such that stepping on the location leads to a complete stop of the wheel at the vertically upright position. In contrast to most reference points for stepping based on pendulum models such as the capture point, our reference point exists on both level and non-level grounds. Moreover, in contrast with continuously evolving step locations, our step location is stationary. The computation of the location of the reference point also generates the duration of step which can be used for designing a stepping trajectory. Momentum-based stepping for push recovery is implemented in simulations of a full size humanoid on 3D non-level ground.
AUTOIMMUNE RETINOPATHY MIMICKING HERITABLE RETINAL DEGENERATION IN A PATIENT WITH COMMON VARIABLE IMMUNE DEFICIENCY (2019)

Autoimmune retinopathy can be seen in common variable immune deficiency and has clinical findings similar to heritable photoreceptor degeneration. Both the humoral and cellular immune responses are involved in the pathophysiology. Immune modulatory therapy has stabilized the disease course in this patient and may play an important role in the management of autoimmune retinopathy.
Mathematical model for empirically optimizing large scale production of soluble protein domains (2010)

Our mathematical modeling of protein dissection protocols indicates that the optimum number of fragments tested per domain is actually much smaller than expected a priori. The application range of our model is not limited to protein dissection, and it can be utilized for designing various large-scale mutational analyses or screening libraries.
Supplementary Figure 4 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment (2023)

&lt;p&gt;PDF file - 185K&lt;/p&gt;
Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations (2021)

Current dry powder formulations for inhalation deposit a large fraction of their emitted dose in the upper respiratory tract where they contribute to off-target adverse effects and variability in lung delivery. The purpose of the current study is to design a new formulation concept that more effectively targets inhaled dry powders to the large and small airways. The formulations are based on adhesive mixtures of drug nanoparticles and nanoleucine carrier particles prepared by spray drying of a co-suspension of leucine and drug particles from a nonsolvent. The physicochemical and aerosol properties of the resulting formulations are presented. The formulations achieve 93% lung delivery in the Alberta Idealized Throat model that is independent of inspiratory flow rate and relative humidity. Largely eliminating URT deposition with a particle size larger than solution pMDIs is expected to improve delivery to the large and small airways, while minimizing alveolar deposition and particle exhalation.
WE‐B‐I‐609‐01: The Ultrasound Research Interface: A New Tool for Biomedical Investigations (2005)

Digitally controlled ultrasound scanners offer extensive levels of programmability, which enable manufacturers to explore and to readily incorporate alternative beam formation, signal and image processing, networking, and interfacing capabilities. Recent efforts have led manufacturers to share these tools for innovation with academic and clinical researchers. This discussion will present capabilities of two such machines and present examples of research uses. The Axius Direct Ultrasound Research Interface (URI) available on the Siemens SONOLINE Antares ™ scanner enables users to acquire raw radio frequency data from regions of interest throughout the image plane. Echo data are available in B‐mode, M‐mode, pulse Doppler and color flow imaging modes. Data can be acquired to a file with a simple button press. Also, user defined scripts can be used to record and reproduce RF acquisitions for combinations of front panel control settings such as transmit level, center frequency, beam angle, and focal depth. The NIH supported development of the interface is complemented by a set of Matlab tools developed at the University of California at Davis, which read echo and image data and perform image processing operations. The Sonix RP research system from Ultrasonix is based on an open PC platform, in which the conventional exam software can run either as a single application or as one of separate windows on the display. The PC also runs connectivity, interface and control software in parallel. The computer can control imaging parameters and apply various post‐processing and display methods in real‐time on RF, I/Q and envelope data to output and store the ultrasound information. When in research mode, users can build, develop, and run client software applications in the Microsoft Visual Studio environment to do customized signal processing, carry out special echo acquisition sequences, and synchronize with external devices, such as stepper motors. These tasks can be accomplished either locally or over a network. Examples of the use of these systems that will be outlined include parametric ultrasound imaging, elasticity imaging, and measuring the speed of sound in pulse‐echo mode.
ChemInform Abstract: Synthesis and Structural Characterization of Helix‐Forming β‐Peptides: trans‐2‐Aminocyclopentanecarboxylic Acid Oligomers. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Color-dependent banding characterization and simulation on natural document images (2011)

Print defects like banding from a digital press involve not only luminance variation, but also chrominance variation. As digital presses place one color separation at a time, the contrast and spatial pattern of the print defects are color-space dependent. Characterizing the color-dependent features of the banding signal enables us to simulate the banding on natural document images in a more accurate way that matches the characteristics of the banding generation mechanism within the digital press. A framework is described for color-dependent banding characterization including the following steps: printing and scanning uniform patches that sample colorant combinations throughout the input document sRGB color space, extracting banding signals in the CMYK color space of the target device, and modeling the banding features in a perceptually uniform color space. We obtain a full banding features LUT for every color point in the input sRGB space by interpolating banding features extracted from measured color points. The color-dependent banding simulation framework is developed based on the banding features LUT. Using the information contained in this LUT, a single banding prototype signal is modulated in a color-space-dependent fashion that varies spatially across the natural document image. Proper execution of the framework of banding characterization and simulation requires careful calibration of each system component, as well as implementation of a complete color management pipeline.
On the Secondary Capacity of the Communication Protocols (2009)

In this paper we consider secondary communication channels, defined via utilization of the protocol overhead information in legacy communication systems, here referred to as primary systems. The secondary communication is carried out by rearranging the order of the packets which are put forward for transmission by the primary system. To motivate the models, we provide several scenarios with wireless primary communication systems. The secondary communication can be seen as a special case of cognitive radio, since additional information is sent by using the same spectrum as the primary system and without affecting the performance of the primary system. The primary system is frame-based and it determines a set of packets that need to be delivered within a frame. The arrangements of the packets within the frame is irrelevant for the primary system and that is creating the opportunity for secondary communication. We define two generic communication models, the permutation model and the combinatorial model, respectively. For both models, we define suitable discrete communication channels, where the error models are obtained by suitably transforming the packet erasures in the primary system. The capacity of these channels is analyzed. It turns out that the capacity results for the combinatorial communication model are related to the fundamental result by Shannon regarding channels with causal side information at the transmitter. The ideas presented in this paper set several interesting directions for future work.
Technical Reports Interbody device endplate engagement effects on motion segment biomechanics (2009)

BACKGROUND CONTEXT: Stand-alone nonbiologic interbody fusion devices for the lumbar spine have been used for interbody fusion since the early 1990s. However, most devices lack the stability found in clinically successful circumferential fusion constructs. Stability results from cage geometry and device/vertebral endplate interface integrity. To date, there has not been a published comparative biomechanical study specifically evaluating the effects of endplate engagement of interbody devices. PURPOSE: Lumbar motion segments implanted with three different interbody devices were tested biomechanically to compare the effects of endplate engagement on motion segment rigidity. The degree of additional effect of supplemental posterior and anterior fixation was also investigated. STUDY DESIGN/SETTING: A cadaveric study of interbody fusion devices with varying degrees of endplate interdigitation. OUTCOME MEASURES: Implanted motion segment range of motion (ROM), neutral zone (NZ), stiffness, and disc height. METHODS: Eighteen human L23 and L45 motion segments were distributed into three interbody groups (n56 each) receiving a polymeric (polyetheretherketone) interbody spacer with small ridges; a modular interbody device with endplate spikes (InFix, Abbott Spine, Austin, TX, USA); or dual tapered threaded interbody cages (LT [Lordotic tapered] cage; Medtronic, Memphis, TN, USA). Specimens were tested intact using a 7.5-Nm flexion-extension, lateral bending, and axial torsion flexibility protocol. Testing was repeated after implantation of the interbody device, anterior plate fixation, and posterior interpedicular fixation. Radiographic measurements determined changes in disc height and intervertebral lordosis. ROM and NZ were calculated and compared using analysis of variance. RESULTS: The interbody cages with endplate spikes or threads provided a statistically greater increase in disc height versus the polymer spacer (p5.01). Relative to intact, all stand-alone devices significantly reduced ROM in lateral bending by a mean 37% to 61% (p#.001). The cages with endplate spikes or threads reduced ROM by ~50% and NZ by ~60% in flexion-extension (p#.02). Only the cage with endplate spikes provided a statistically significant reduction in axial torsion ROM compared with the intact state (50% decrease, p!.001). Posterior fixation provided a significant reduction in ROM in all directions versus the interbody device alone (p!.001). Anterior plating decreased ROM over interbody device alone in flexion-extension and torsion but did not have additional effect on lateral bending ROM.
Spatial Correlation Variability in Multiuser Systems (2018)

Spatial correlation across an antenna array is known to be detrimental to the terminal signal-to- interference-plus-noise-ratio (SINR) and system spectral efficiency. For a downlink multiuser multiple-input multiple-output system (MU-MIMO), we show that the widely used, yet overly simplified, correlation models which generate fixed correlation patterns for all terminals tend to underestimate the system performance. This is in contrast to more sophisticated, yet physically motivated, remote scattering models that generate variations in the correlation structure across multiple terminals. The remote scattering models are parameterized with measured data from a recent 2.53 GHz urban macrocellular channel measurement campaign in Cologne, Germany. Assuming spatially correlated Ricean fading, with maximum-ratio transmission precoding, tight closed-form approximations to the expected (average) SINR, and ergodic sum spectral efficiency are derived. The expressions provide clear insights into the impact of variable correlation patterns on the above performance metrics. Our results demonstrate the sensitivity of the MU-MIMO performance to different correlation models, and provide a cautionary tale of its impact.
Ada usage/performance specification (1990)

article Free Access Share on Ada usage/performance specification Authors: M. W. Borger View Profile , J. B. Goodenough View Profile Authors Info & Claims ACM SIGAda Ada LettersVolume XIssue 9Fall 1990 pp 65–69https://doi.org/10.1145/102456.102474Online:01 June 1990Publication History 0citation152DownloadsMetricsTotal Citations0Total Downloads152Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Evidence for Direct Cross‐talk between AMP‐activated kinase (AMPK) and O‐linked β‐N‐Acetylglucosaminyltransferase (OGT) (2011)

Cycling of O ‐linked β ‐ N ‐acetylglucosamine ( O ‐GlcNAc; a Ser/Thr specific post‐translational modification on nucleocytoplasmic proteins) is a nutrient sensing process regulated by O ‐GlcNAc transferase (OGT). Activation of AMP‐activated kinase (AMPK), a vital regulator of cellular energy homeostasis, is also a nutrient sensing process. AMPK and OGT share many downstream targets with the net effect to prolong cell viability under metabolic stress, suggesting significant overlap in AMPK and OGT signaling. However, no studies have investigated whether AMPK and OGT are capable of direct cross‐talk with each other. We demonstrate that: 1) The α and γ subunits of AMPK are GlcNAcylated, 2) Pharmacological and glucose deprivation induced activation of AMPK increases GlcNAcylation of the γ1 subunit, 3) global elevation of GlcNAcylated protein inhibits glucose deprivation induced activation of AMPK, 4) AMPK phosphorylates Thr 172 of OGT in vitro, 5) Acute AMPK activation alters OGT's substrate selectivity. All experiments were performed in differentiated C2C12 myotubes. Collectively, these results demonstrate significant cross‐talk between the AMPK and O ‐GlcNAc systems, possibly via coordinated signaling between AMPK and OGT. (Supported by NIH grant R01 DK61671 and R01 CA42486. Dr. Hart receives a share of royalty received by the university on sales of the CTD 110.6 antibody. Terms of this arrangement are managed by JHU).
Crystalline Nanorods as Possible Templates for the Synthesis of Amorphous Biosilica during Spicule Formation in Demospongiae (2009)

High-resolution microscopy shows that, during the initial stages of demosponge spicule formation, a primordial crystalline structure is formed within the axial filament. The recently developed electron diffraction tomography technique reveals that the nanorods have a layered structure that matches smectitic phyllosilicates. These intracellular nanorods have been considered as precursors of mature spicules.
Design of Tracking Controller for Holographic Digital Data Storage (2007)

In this paper we present a new tracking control method for holographic digital data storage systems. Holographic data storage systems that use disk media need a different tracking method from those of optical and hard disk drives. Here we present the design and implementation of the controller. Due to the intermittent characteristics of the tracking error signal (TES), the tracking controller is designed to regulate the tracking error only while valid TES is generated. Since the valid TES appears intermittently, we use a feedforward controller while the TES is not valid. Furthermore, the feedback control and feedforward control are mode switched depending on the radio frequency sum signal level. We also show the stability of the closed loop system employing the mode switching controller. Experimental results show the effectiveness of the proposed tracking control algorithm. For a plusmn100 mum repeatable runout at 1 Hz, we were able to reduce the TES to 3.13 mum (1sigma) with feedforward mode switching control.
Abstract A44: Predictive biomarkers of efficacy to the hedgehog pathway inhibitor, GDC-0449, in advanced basal cell carcinoma and medulloblastoma in phase I studies (2009)

Abstract The Hedgehog (Hh) signaling pathway has been directly implicated in the pathogenesis of basal cell carcinoma (BCC) and medulloblastoma (MB). Constitutive Hh signaling, most often due to underlying loss of function mutations in the inhibitory receptor Patched1 (PTCH1), has been demonstrated in a majority of common localized BCCs and approximately 25–30% of sporadic MB cases. In this study, we examined molecular correlatives of clinical efficacy in locally-advanced / metastatic BCC and MB patients treated with GDC-0449, an inhibitor of the Hh pathway that targets the serpentine receptor Smoothened (SMO). An analysis of Hh pathway transcriptional target gene expression in archival tissue biopsies provided evidence for active Hh signaling in patients exhibiting clinical benefit (objective response or disease stabilization) on therapy. This was further supported by the identification of either loss of function or activating mutations in PTCH1 or SMO, respectively. We were unable to provide evidence for active Hh signaling in 2 patients with progressive disease as best response, potentially underlying the reason for lack of efficacy in these patients. In addition to providing molecular support for Hh pathway activity in patients exhibiting treatment benefit, this is the first evidence for Hh pathway dysregulation in the previously uncharacterized, advanced BCC setting. Furthermore, the results begin to support the utility of transcriptional-based tests as a strategy to potentially select the subset of MB patients with Hh-driven disease that would likely benefit on GDC-0449. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):A44.
Cloud-Based Model Calibration Using OpenStudio (2014)

OpenStudio is a free, open source Software Development Kit (SDK) and application suite for performing building energy modeling and analysis. The OpenStudio Parametric Analysis Tool (PAT) was extended to allow cloud-based simulation of multiple OpenStudio models parametrically related to a baseline model. This paper describes the new cloud-based simulation functionality and presents a model calibration case study. Calibration is initiated by entering actual monthly utility bill data into the baseline model. Multiple parameters are then varied over multiple iterations to reduce the difference between actual energy consumption and model simulation results, as calculated and visualized by billing period and by fuel type. Simulations are performed in parallel using the Amazon Elastic Compute Cloud service. This paper highlights model parameterizations (measures) used for calibration, but the same multinodal computing architecture is available for other purposes; for example, recommending combinations of retrofit energy saving measures using the calibrated model as the new baseline.
A phase II study of laquinimod in Crohn's disease (2014)

NCT00737932.
Search for new physics in the monophoton final state in proton-proton collisions at s = 13 $$ \sqrt{s}=13 $$ TeV (2017)

A search is conducted for new physics in a final state containing a photon and missing transverse momentum in proton-proton collisions at s = 13 TeV. The data collected by the CMS experiment at the CERN LHC correspond to an integrated luminosity of 12.9 fb -1 . No deviations are observed relative to the predictions of the standard model.