gebhart/patrepeval huggingface dataset:
Klinokinetic and klinotactic humidity reactions of the beetles Hylobius abietis and Tenebrio molitor (1980)

ABSTRACT. The effects of spatially uniform but temporally changing air humidity stimuli on the orientation behaviour of the large pine weevil ( Hylobius abietis L.) and the flour beetle ( Tenebrio molitor L.) were studied in a specially constructed vertical air flow chamber. Moist‐acclimatized but hygronegative pine weevils were exposed for 10 s to a moist air stream ( c. 85% R.H.) and then for 10 s to a dry air stream ( c. 50% R.H.). The Tenebrio were divided into two groups acclimatized to moist and dry air respectively. For each group the humidity during the initial 5 s in the air stream was the same as during acclimatization, and then changed to the alternative level. In Hylobius the change from moist to dry air caused a decrease in spatial displacement brought about by a decrease in walking speed and an increase in the amount of turning per unit time. In Tenebrio the change from dry to moist air caused a decrease of walking speed and a turning‐back reaction based, presumptively, on idiothetic information about the insect's previous walking direction. The average angle turned during 2 s after the humidity change was 165°. In moist‐adapted beetles the dry air stream caused an identical orthokinetic arrestment, but no klinokinetic or klinotactic reaction. Klinokinesis is redefined as a change in the circular variance of turning angles per unit time, which does not change the mean direction (or directions in cases of multimodal distributions) of the circular distribution. Accordingly, klinotaxis consists of a change in the mean directions) of the circular distribution of angular velocities. In both species the turning frequency was more constant than turning per unit distance, suggesting a temporal control in the nervous system of klinokinetic and klinotactic behaviour.
Molecular Monolayer Nonvolatile Memory with Tunable Molecules (2009)

Einfach unvergesslich: 3 nm dicke selbstorganisierte Monoschichten aus Metallkomplexen mit Dialkylthiolatresten (siehe Bild) ergeben einen stabilen, reproduzierbar arbeitenden, nichtflüchtigen Datenspeicher aus einer molekularen Monoschicht (MMNVM) mit charakteristischen I-V-Hysteresekurven und Retentionszeiten für gepulste Zyklen aus Lesen, mehrfachem Schreiben, Löschen und mehrfachem Schreiben. Dies ist der erste spannungsgetriebene MMNVM, der allein auf Basis einer molekularen Monoschicht arbeitet. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Autoantibodies to neutrophil cytoplasmic enzymes in Felty's syndrome. (1993)

In this study we determined the occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) and the specificity of these antibodies (Ab) in the serum of patients with Felty's syndrome (FS) and in serum of patients with uncomplicated rheumatoid arthritis (RA). ANCA, detected by indirect immunofluorescence on ethanol-fixed neutrophils, was found in 77% of 30 patients with FS and in 36% of 50 RA patients. Ab against lactoferrin (LF) occurred more frequently in FS patients (50%) than in RA patients (4%), whereas reactivity against the other cytoplasmic antigens tested (proteinase-3, myeloperoxidase and elastase) did not differ significantly between these patient groups. The specific reactivity of FS sera with LF was established by demonstrating that the Ab reactivity resided in IgG, was located in the F(ab')2 fragments and could be inhibited from binding to the ELISA plate-bound LF by purified LF in the fluid phase. These results demonstrate that anti-LF Ab occur in FS and suggest that the detection of anti-LF Ab in patients with FS may be useful in the diagnosis of FS.
Development of a high-performance cutting device based on hybrid actuation for ultra-precision machining (2022)

In ultra-precision cutting, the inherent working frequency and positioning accuracy of actuators are decisive. It is challenging to generate multi-scale cutting motions with high accuracy on hierarchical scale simultaneously. In this study, a novel micro and nano-cutting device with complex-axis is developed, consisting of a customized designed linear voice coil motor and a piezoelectric actuated flexure-hinge mechanism to generate micro and nano-cutting motions, respectively, for overcoming the challenge. The structure of the cutting device is designed with a small form factor in dimension in comparison to other auxiliary cutting devices for ultra-precision machine tools. The magnetic field simulation is also used to optimize the output force of the voice coil motor with the simulation results validated by experiments using a force sensor. The operation mechanism of the flexure-hinge is investigated by finite element analysis. The device can perform ± 0.5 mm stroke at 10 Hz and ± 8 µm at 3300 Hz for generation of microstructures with experimental validation. The significance and originality of this study lie in the successful development of a novel hybrid actuation cutting system that can generate multi-scale cutting motions with high accuracy and flexibility on a hierarchical scale for the generation of microstructured surfaces in ultraprecision machining.
Cellular Characterization of Algal Biomass Acid-Catalyzed Conversion using Hyperspectral Imaging . (2020)

Abstract not provided.
BBN VISER TRECVID 2014 Multimedia Event Detection and Multimedia Event Recounting Systems. (2014)

In this paper, we describe the Raytheon BBN Technologies (BBN) led VISER system for the TRECVID 2014 Multimedia Event Detection (MED) and Recounting (MER) tasks. We present a comprehensive analysis of the different modules: (1) Metadata Generator (MG) – a large suite of audio-visual low-level and sematic features; a set of deep convolutional neural network (DCNN) features trained on the ImageNet dataset; automatic speech recognition (ASR); videotext detection and recognition (OCR). For the low-level features, we used D-SIFT, Opponent SIFT, dense trajectories (HOG+HOF+MBH), MFCC and Fisher Vector (FV) representation. For the semantic concepts, we have trained 1,800 weakly supervised concepts from the Research Set videos and a set of YouTube videos. These concepts include objects, actions, scenes, as well as noun-verb bigrams. We also consider the output layer of the DCNN as a 1,000-dimensional semantic feature. For the speech and videotext content, we leveraged rich confidence-weighted keywords and phrases obtained from the BBN ASR and OCR systems. (2) Event Query Generation (EQG)- linear SVM event models are trained for each feature and combined using probabilistic late fusion framework. Our system involves both SVM-based and query-based detections, to achieve superior performance despite the varying number of positive videos in the different training conditions. We present a thorough study and evaluation of different
PI3 KINASE INHIBITION PROMOTES TOLEROGENIC CD8 T CELL FUNCTION IN LUNG TRANSPLANT RECIPIENTS (2020)

Purpose: Lung transplant (LTx) recipients with significant cigarette smoke (CS) exposure histories continue to have poorer long-term outcomes. We utilized a systems biology approach to analyze a novel murine model of allogeneic LTx into CS exposed recipients. Our model system mapped the clinical scenario and through in-silico modeling, we sought to identify therapeutic targets that could modulate post-Tx outcomes in the CS exposed patient population. Methods and Results: C57Bl/6 mice were either chronically exposed to CS, or room air (NS) prior to receiving a LTx from non-smoke exposed Balb/cage matched controls. Lungs were harvested at 7 days post-LTx upon which histological, nanostring mRNA immune profiling, and flow cytometry assays were performed. We demonstrate that acute rejection is exacerbated in CS recipients as compared to NS controls (Figure 1). Principle component analysis of nanostring data revealed significant differences IL17A, CTLA4, IL6, and IL4 pathways in CS vs NS. In-silico modeling predicted PI3K pathway inhibitor LY294002 (LY) could reverse this exacerbated rejection phenotype. LY294002 therapy restored the CS recipient to a rejection profile in keeping with that seen in NS recipients (Figure 1). The nanostring analysis suggested a significant role for CD8+ T cells in these responses. Given this, we then reconstituted untreated CD8+ cells into CD8 KO mice prior to LTx. This experiment replicated our observed rejection patterns, thus implicating the CD8+ population as a key regulator of CS-related alloimmunity (Figure 2). Flow cytometry further revealed significant alterations in splenic CD8 central memory (CM) versus effector memory (EM) ratios, with EM predominating in CS mice pre-LTx, as compared to NS. Treatment with LY restored the CM:EM ratio in CS samples, both in-vitro and in-vivo. We then expanded CS and NS CM CD8+ T cells in vitro and reconstituted CD8 KO mice prior to LTx with these CM CD8+ T cells. At 7 days post-LTx, rejection was ameliorated in the CS CM CD8+ group versus non-reconstituted controls and was similar to the NS CM CD8+ group (Figure 3). Conclusion: Pre-transplant CS exposure, particularly in COPD and IPF patients, pre-disposes to poorer post-Tx outcomes. Using a novel LTx system and in-silico modeling we have identified PI3K inhibition as a novel therapeutic approach predicted to be efficacious in CS exposed LTx recipients. The mechanism is at least in part mediated through a preferential skewing of CD8+ T cells towards a central memory phenotype, which appears to have a protective effect in LTx of CS-exposed recipients.
ChemInform Abstract: A Convenient, Efficient Method for Conjugate Reductions Using Catalytic Quantities of Cu(I). (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Limitations of cancer care in Central and South-Eastern Europe: results of the international conference organized by the Central European Cooperative Oncology Group (CECOG) (2020)

Profound disparities in cancer incidence and treatment outcomes, as well as accessibility of innovative EMA approved medications and technologies exist between Central, Eastern and South-Eastern (CEE) European countries and neighbouring Western European (WE) countries. An international expert conference was held to discuss the current situation regarding the availability and affordability of innovative anti-cancer drugs in CEE, to define shortcomings in cancer care and to specify possible solutions to overcome the lack of access to anti-cancer medications in the region. Consequently, all experts agreed that national prevention programs targeting smoking, obesity and alcohol consumption, and cancer screening programmes should be widely implemented in CEE countries. Considering limited healthcare resources in most CEE countries, an efficient allocation in a more structured way with clear cancer patient pathways to contain costs is needed. Also, more rapid reimbursement decisions and introduction of novel drugs in routine clinical practice, along with better access to clinical trials, are needed. There was consensus that higher investments into cancer care and more organized, value-oriented application of novel diagnostic and treatment approaches are necessary. Furthermore, it was suggested that patient organisations should be more involved in cancer research, clinical research and reimbursement processes. Postulated were also higher investments into cancer care and more organized, value-oriented application of novel diagnostic and treatment approaches.
Human <em>in situ </em>Study of the Effect of bis(2-methacryloyloxyethyl) Dimethylammonium Bromide Immobilized in Dental Composite on Controlling Mature Cariogenic Biofilm (2018)

Cariogenic oral biofilms cause a considerable amount of recurrent dental caries around composite restorations every year, resulting in unprosperous oral health status and expensive restorative treatment for many patients. Quaternary ammonium monomers that can be copolymerized with the current dental resin systems have been increasingly explored for modulation of dental plaque biofilm growth over dental composite surfaces. Here, we investigated the effect of bis(2-methacryloyloxyethyl) dimethylammonium bromide (QADM), against human overlying mature oral biofilms grown intra-orally in human participants for 7 and 14 days, for the first time. Seventeen volunteers wore palatal devices containing composite specimens containing 10% by mass of QADM or a control composite without QADM. After 7 and 14 days, the adherent biofilms were collected for determination of bacterial counts via colony-forming unit (CFU) counts. The biofilm viability, chronological changes, and percentage coverage were also determined by live/dead staining. QADM composites caused a significant inhibition of S. mutans biofilm formation for up to seven days. No difference in the CFU values were found for the 14-day period. Our findings suggest that (1) QADM composite was successful in inhibiting 1-3 day biofilms in the oral environment in vivo; (2) QADM significantly reduced the portion of S.mutans group in a time course where patients at high risk of caries would develop initial enamel carious lesions; and (3) stronger antibiofilm activity is required for the control of mature long-term cariogenic biofilms. These results provide a perspective on the value of integrating bioactive restorative materials with traditional caries management approaches into clinical practice. Contact-killing strategies via dental materials aiming to prevent or at least reduce high numbers of cariogenic bacteria seem to be a promising approach in patients at high risk of recurrence of dental caries around composites.
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities (2012)

Conventional chemotherapy not only kills tumor cells but also changes gene expression in treatment-damaged tissues, inducing production of multiple tumor-supporting secreted factors. This secretory phenotype was found here to be mediated in part by a damage-inducible cell-cycle inhibitor p21 (CDKN1A). We developed small-molecule compounds that inhibit damage-induced transcription downstream of p21. These compounds were identified as selective inhibitors of a transcription-regulating kinase CDK8 and its isoform CDK19. Remarkably, p21 was found to bind to CDK8 and stimulate its kinase activity. p21 and CDK8 also cooperate in the formation of internucleolar bodies, where both proteins accumulate. A CDK8 inhibitor suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts and reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with a chemotherapeutic drug. The inhibitor also increases the efficacy of chemotherapy against xenografts formed by tumor cell/fibroblast mixtures. Microarray data analysis revealed striking correlations between CDK8 expression and poor survival in breast and ovarian cancers. CDK8 inhibition offers a promising approach to increasing the efficacy of cancer chemotherapy.
ChemInform Abstract: Practical Application of the Palladium‐Catalyzed Amination in Phenylpiperazine Synthesis: An Efficient Synthesis of a Metabolite of the Antipsychotic Agent Aripiprazole. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CAIRN: Dedicated Integer Factoring Devices (2010)

The integer factoring problem is known as one of the hard problem in cryptology, and some public-key cryptosystems including RSA are designed based of this fact. Recently, several dedicated integer factoring devices have been proposed, however, no implementational or even experimental results are not shown. This paper proposes a novel design of a dedicated integer factoring device. In order to verify the do ability of the design, we actually developed the dedicated integer factoring devices CAIRN 1, 2 and 3. CAIRN 1 is the first and concept proof device implemented on DAP-DNA2, while CAIRN 2 is implemented on Xilinx's FPGA and succeeded factoring a 128-bit composite integer whose factor was unknown at that time. CAIRN 3 is also implemented on Xilinx's FPGA, and is about 38 times faster than CAIRN 2 in the experimental sieving for a 768-bit integer (RSA 768). It is estimated that the full sieving for RSA 768 requires about 270 years with single CAIRN 3.
Immune and Cell Therapy in Non-Hodgkin Lymphoma (2020)

The promise of immunotherapy has shone brightly for decades in hematologic malignancies and specifically in non-Hodgkin lymphoma. The last decade has witnessed the emergence of completely novel forms of immunotherapy, including immune checkpoint blockade, bispecific antibodies, and chimeric antigen receptor T cells. These treatments have shown phenomenal, and in some cases possibly curative, successes in various relapsed/refractory lymphomas. This review summarizes the most notable successes and promising findings as well as some of the attendant failures. These treatments will doubtlessly transform the treatment paradigms across many lymphoma subtypes. Yet, only if we can better understand their mechanisms of action, toxicity, and resistance will be able to maximize their therapeutic benefit.
Transcription of deleted mitochondrial DNA in human colon adenocarcinoma cells (1992)

Journal Article Transcription of deleted mitochondrial DNA in human colon adenocarcinoma cells Get access Isabelle Savre-Train, Isabelle Savre-Train Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Centerat Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235–9039, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Mieczyslaw A. Piatyszek, Mieczyslaw A. Piatyszek Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Centerat Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235–9039, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Jerry W. Shay Jerry W. Shay * Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Centerat Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235–9039, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 1, Issue 3, June 1992, Pages 203–204, https://doi.org/10.1093/hmg/1.3.203 Published: 01 June 1992 Article history Received: 07 April 1992 Published: 01 June 1992
A Super-Extended Zel'dovich Mechanism for Nox Modeling and Engine Calibration (1998)

&lt;div class="htmlview paragraph"&gt;A new reaction scheme for NO&lt;sub&gt;x&lt;/sub&gt; production is incorporated into a steady state quasi-dimensional engine combustion simulation. The reaction kinetics includes 67 reactions and 13 chemical species, and assumes equilibrium concentration for all other chemical species. The General Engine SIMulation (GESIM) developed by Ford Motor Company is used to model the engine cycle. The new reaction scheme is a super-extended Zel'dovich mechanism (SEZM) which predicts NO&lt;sub&gt;x&lt;/sub&gt; formation levels to within 10% of engine test data for several engines, whereas the 3 reaction, extended Zel'dovich mechanism (EZM) is shown to have errors of approximately 50% or more for similar conditions. Analytical engine mapping, under NO&lt;sub&gt;x&lt;/sub&gt; constrained calibration, requires accurate modeling of NO&lt;sub&gt;x&lt;/sub&gt; emissions over varying engine operating conditions. A methodology for performing an analytical engine map will be presented and the benefits of the SEZM will be shown, as well as a detailed comparison with the EZM for two complete engine maps.&lt;/div&gt;
Host plant use of Helicoverpa spp. (Lepidoptera: Noctuidae) in the Brazilian agricultural landscape (2020)

Regional differences in the host use and population dynamics of H. armigera among the regions evaluated may be attributed to variation in alternative host utilization (crops, noncrops, and weeds) and the possible occurrence of facultative diapause and or migration.
L’EJP One Health, projet européen de programmation conjointe et de financement de la recherche sur les zoonoses alimentaires (2018)

L’EJP One health est un projet européen de recherche destiné à éclairer la décision publique dans le domaine de la sécurité sanitaire des aliments (One Health EJP). Il a pour objectif de contribuer à renforcer les liens existants entre santé animale, santé humaine et l’environnement selon la démarche “Une seule santé”. Co-financé par la Commission Européenne et les états membres de l’Union Européenne, ce projet regroupe 39 partenaires de 19 états membres. Ces centres publics de recherche, soit en santé publique soit en santé animale, mènent des travaux de recherche sur les zoonoses alimentaires, l’antibiorésistance et les maladies émergentes alimentaires tout en assurant les mandats de référence correspondants. La mise en œuvre de la démarche “Une seule santé” se fait par la mobilisation des deux communautés “Med” et “Vet”, dans une approche multidisciplinaire. Les priorités thématiques de recherche sont définies par les instituts de recherche après consultation des agences nationales et européennes d’évaluation des risques. Par cette approche l’EJP One Health est un projet de recherche destinée à générer des informations scientifiques essentielles à l’analyse et à l’évaluation des risques sanitaires, et à ce titre est en appui à la décision publique.
Toward the massive genome of Proteus anguinus — illuminating longevity, regeneration, convergent evolution, and metabolic disorders (2021)

Perspective on the sequencing of the olm's (<em>Proteus anguinus</em>) genome and its impact on evolutionary biology, biomedical research, and conservation. Assembling the large genome of the olm is a challenge, but will also offer new insights into the structure and evolution of massive genomes. The olm's ability to regenerate limbs and its extreme longevity offer insights of biomedical interests, while its cave-adapted traits will help to illuminate the evolutionary processes and genetic mechanisms involved in the transition from surface to the subterranean realm.
Approximate Search on Massive Spatiotemporal Datasets (2012)

Efficient time series similarity search is a fundamental operation for data exploration and analysis. While previous work has focused on indexing progressively larger datasets and has proposed data structures with efficient exact search algorithms, we motivate the need for approximate query methods that can be used in interactive exploration and as fast data analysis subroutines on large spatiotemporal datasets. We formulate a simple approximate range query problem for time series data, and propose a method that aims to quickly access a small number of high quality results of the exact search result set. We propose an evaluation strategy on the query framework when the false dismissal class is very large relative to the query result set, and investigate the performance of indexing novel classes of time series subsequences.
Supplementary Figures 1-3 from The High-Mobility Group A1 Gene Up-Regulates Cyclooxygenase 2 Expression in Uterine Tumorigenesis (2023)

Supplementary Figures 1-3 from The High-Mobility Group A1 Gene Up-Regulates Cyclooxygenase 2 Expression in Uterine Tumorigenesis