gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of Sr[sub 2]MgMoO[sub 6−δ] (2006)

The double-perovskite (SMMO) was investigated as an anode material of a solid oxide fuel cell. Via a synthetic method based on thermal decomposition of metal complexes with ethylenediaminetetraacetic acid as the complexant, phase-pure SMMO was readily obtained. Oxygen vacancies are introduced by reduction with 5% at . With a thick disk as the electrolyte and as the cathode, the SMMO anode showed power densities of in and in at . Moreover, it performed stably on power cycling and tolerated sulfur and moisture well. Only 1% degradation in the output was observed in containing and 16% degradation in containing compared with the output in pure . Thermogravimetric analysis showed a drop in mass at around in the atmospheres of both air and 5% , indicative of the formation of oxygen vacancies. The mean thermal expansion coefficient was at the operating temperatures. The conductivity strongly depended on the atmosphere, and the electronic activation energies were in and in . Our results show that SMMO is a potential anode material for operation with natural gas.
Influence of Surface Anchoring Energy and Mesogenic Polymer-Stabilization on the Electro-Optic Characteristics of FLCD Exhibiting Half-V-Switching (2002)

In this paper, we report that the electrooptic (EO) performance of a polymer stabilized ferroelectric liquid crystal display (PS-FLCD) exhibiting half-V-shaped switching using an FLC material which has no SmA phase-R2301 (Clariant Japan) depends on the surface alignment conditions such as photoalignment and rubbing. It is shown that an FLCD cell fabricated using the photoalignment technique, which produces weak azimuthal anchoring, results in a superior EO performance at a low saturation operation voltage and for a wide cone (deflection) angle compared to those fabricated under a weak-rubbing condition.
Feasibility optimality of periodwise static priority policies for a quality of service model in wireless networks and convergence analysis for an online recommendation system (2011)

In the first part of this thesis, we consider a proposed Quality of Service&#13;\n(QoS) model in which a set of clients require their own timely-throughput&#13;\nfrom an access point, with packet deadlines restricted to be in one period. It is&#13;\nknown that two debt-based policies, including time-based debt and weighted&#13;\ndelivery-based debt, are feasibility optimal in the sense that they can fulfill&#13;\nthe requirements of all sets of feasible clients. We analyze why these poli-&#13;\ncies are optimal by considering a class of periodwise static priority policies.&#13;\nWe prove that this latter class of policies can achieve whatever a history-&#13;\ndependent policy can, i.e., it suffices to consider only this class of policies&#13;\nfor such a scheduling problem. Our approach proceeds by investigating the&#13;\nsubmodularity of the complement of the idle time function. We thereby show&#13;\nthat the set defined by the timely-throughput constraints is a polymatroid,&#13;\nfrom which the optimality within the class of periodwise static priority poli-&#13;\ncies follows.&#13;\nThe second part of the thesis analyzes the convergence of an algorithm&#13;\nfor the problem of learning with expert advice. At the present time, several&#13;\nweb-based recommendation systems use votes from experts or other users to&#13;\nrecommend objects to other customers. We apply the `learning from expert&#13;\nadvice' framework for this system, and propose a recommendation algorithm&#13;\nthat uses a weighted update rule. Often, recommendation algorithms make&#13;\nassumptions that do not hold in practice, such as requiring a large number of&#13;\ngood objects, presence of experts with the identical taste as the user receiving&#13;\nthe recommendation, or experts who vote on all or a majority of objects. Our&#13;\nalgorithm relaxes these assumptions by allowing an arbitrary proportion of&#13;\nbad objects as well as arbitrary tastes of experts. Moreover, it can deal with&#13;\nthe issues that arise because of the existence of sleeping-experts, i.e., experts&#13;\nwho are not available for voting at all rounds. A key attribute of our approach&#13;\nis to define the concept of the best expert on the basis of both availability&#13;\nand accuracy of experts. We then prove that the algorithm converges almost&#13;\nsurely to the best expert(s) regardless of whether the predictions of experts&#13;\nare binary or continuous valued. Moreover, we derive an upper bound on&#13;\nloss of the proposed algorithm by comparing it to the loss of an appropriately&#13;\ndefined `current best' and show that the regret of our algorithm is logarithmic&#13;\nin the number of experts. Besides theoretical performance guarantees, we&#13;\npresent simulation results that show the proposed algorithm outperforms&#13;\nDsybil, the current state-of-the-art recommendation algorithm.
ChemInform Abstract: Investigation of the S3 Site of Thrombin: Design, Synthesis, and Biological Activity of 4‐Substituted 3‐Amino‐2‐pyridones Incorporating P1‐Argininals (VIII). (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ability of Bacteriophages Isolated from Different Sources to Reduce Salmonella enterica Serovar Enteritidis In Vitro and In Vivo (2007)

Salmonella enterica serovar Enteritidis-lysing bacteriophages isolated from poultry or human sewage sources were used to reduce Salmonella Enteritidis in vitro and in experimentally infected chicks. Cocktails of 4 different bacteriophages obtained from commercial broiler houses (CB4Ø) and 45 bacteriophages from a municipal wastewater treatment plant (WT45Ø) were evaluated. In experiment 1, an in vitro crop assay was conducted with selected bacteriophage concentrations (10(5) to 10(9) pfu/mL) to determine ability to reduce Salmonella Enteritidis in the simulated crop environment. Following 2 h at 37 degrees C, CB4Ø or WT45Ø reduced Salmonella Enteritidis recovery by 1.5 or 5 log, respectively, as compared with control. However, CB4Ø did not affect total SE recovery after 6 h, whereas WT45Ø resulted in up to a 6-log reduction of Salmonella Enteritidis. In experiment 2, day-of-hatch chicks were challenged orally with 3 x 10(3) cfu/chick Salmonella Enteritidis and treated cloacally with 1 x 10(9) WT45Ø pfu/chick 1 h postchallenge. One hour later, chicks were treated or not with a commercially available probiotic (Floramax-B11). Both treatments significantly reduced Salmonella Enteritidis recovery from cecal tonsils at 24 h following vent lip application as compared with controls, but no additive effect was observed with the combination of bacteriophages and probiotic. In experiment 3, day-of-hatch chicks were challenged orally with 9 x 10(3) cfu/chick Salmonella Enteritidis and treated via oral gavage with 1 x 10(8) CB4Ø pfu/chick, 1.2 x 10(8) WT45Ø pfu/chick, or a combination of both, 1 h postchallenge. All treatments significantly reduced Salmonella Enteritidis recovered from cecal tonsils at 24 h as compared with untreated controls, but no significant differences were observed at 48 h following treatment. These data suggest that some bacteriophages can be efficacious in reducing SE colonization in poultry during a short period, but with the bacteriophages and methods presently tested, persistent reductions were not observed.
Organocatalytic enantioselective conjugate addition of aldehydes to maleimides (2007)

The highly enantioselective direct organocatalytic conjugate addition of aldehydes to maleimides is presented.
Synthese und Struktur von Stibaindolen (1990)

Einen einfachen Zugang zu Stibaindolen eröffnet die Reaktion (a), bei der die monomeren 1‐Cl‐ und 1‐Phenylstibaindole in Ausbeuten von 71–86% entstehen. Das Interesse an heterocyclischen Verbindungen der schweren Hauptgruppenelemente hat in den letzten Jahren wegen ihren Anwendungen in den Materialwissenschaften stark zugenommen. Y, Z  H, OMe, C 4 H 4 . magnified image
Flight 1 technical report for experiment 74-36: Thermal migration of bubbles and their interaction with solidification interfaces (1976)

Specimens of gas saturated carbon tetrabromide were directionally solidified in a transparent furnace using a gradient freeze technique. The original temperature gradient was 5 C/cm and the cooling rate was 40 C/h. Progress of the experiment was monitored photographically. Gas bubbles were generated at the advancing solidification front in each of the three specimens. The gas bubbles were observed to increase in size, coalesce, and eventually be grown into the solid specimen under low gravity conditions. No bubble detachment from the interface was observed. Identical specimens processed in the laboratory showed bubble nucleation, bubble growth, and eventual bubble detachment due to buoyancy forces. Examination of the specimens showed a significantly greater void content in the low gravity processed samples. The grain size was observed to be finer in the low gravity processed samples.
The Synthesis of Disaccharides Terminating in D-Septanosyl Residues Using Acyclic Intermediates (1998)

A general method for the construction of disaccharides containing D-septanosyl residues from acyclic intermediates has been developed. The synthesis of an analogue of N-acetyl d-lactosamine with a d-galactoseptanosyl unit has also been accomplished with the aim of determining the behaviour of this compound as a substrate for several glycosyltransferases.
Conformation of the anticodon loop of phenylalanine transfer ribonucleic acid. Effect of environment on the fluorescence of the Y base (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of the anticodon loop of phenylalanine transfer ribonucleic acid. Effect of environment on the fluorescence of the Y baseKenneth Beardsley, Terence Tao, and Charles R. CantorCite this: Biochemistry 1970, 9, 18, 3524–3532Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/bi00820a005https://doi.org/10.1021/bi00820a005research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and synthesis of multiple-loop receptors based on a calix〚4〛arene scaffold for protein surface recognition (2002)

We have recently reported a synthetic protein binding agent with fourfold symmetry containing four identical peptide loops attached to the four phenyl groups of a calix〚4〛arene core. One of these first generation derivatives not only bound strongly to cytochrome c but also blocked its ability to interact with protein partners or simple reducing agents. In developing second generation protein binding agents with better affinity and selectivity, we required a synthetic approach that would lead to a less symmetrical arrangement of the peptide loops around the core calix〚4〛arene scaffold. We herein report an important step in the wider application of this strategy with the preparation of a series of unsymmetrical receptors in which two different loops are attached to the core calixarene.
Shape analysis of brain ventricles for improved classification of Alzheimer&#x2019;s patients (2008)

One of the hallmarks of Alzheimer's disease (AD) is the loss of neurons in the brain. In many cases, the medical experts use MR (magnetic resonance) images to qualitatively measure the neuronal loss by the shrinkage (atrophy) of the structures-of-interest, or sometimes more easily by the enlargement of the fluid-filled structures, such as the ventricles. For quantitative analysis, volume is the common choice. Volume, or area in 2D, is a gross measure and it cannot capture shape differences that can improve the diagnostic accuracy. Because most existing methods use complex and difficult- to-reproduce shape descriptors, the experts prefer more easily and robustly extractable area and volume in their diagnosis. In this paper, we introduce several novel and easily-extractable 2D shape descriptors for brain ventricle, and show that they and some of the well-known simple shape descriptors, such as perimeter, are better descriptors in the classification of AD patients and healthy controls.
Data from A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;High levels of type I T cells are needed for tumor eradication. We evaluated whether the HER2-specific vaccine–primed T cells are readily expanded &lt;i&gt;ex vivo&lt;/i&gt; to achieve levels needed for therapeutic infusion.&lt;/p&gt;Patients and Methods:&lt;p&gt;Phase I/II nonrandomized trial of escalating doses of &lt;i&gt;ex vivo&lt;/i&gt;–expanded HER2-specific T cells after &lt;i&gt;in vivo&lt;/i&gt; priming with a multiple peptide–based HER2 intracellular domain (ICD) vaccine. Vaccines were given weekly for a total of three immunizations. Two weeks after the third vaccine, patients underwent leukapheresis for T-cell expansion, then received three escalating cell doses over 7- to 10-day intervals. Booster vaccines were administered after the T-cell infusions. The primary objective was safety. The secondary objectives included extent and persistence of HER2-specific T cells, development of epitope spreading, and clinical response. Patients received a CT scan prior to enrollment and 1 month after the last T-cell infusion.&lt;/p&gt;Results:&lt;p&gt;Nineteen patients received T-cell infusions. Treatment was well tolerated. One month after the last T-cell infusion, 82% of patients had significantly augmented T cells to at least one of the immunizing epitopes and 81% of patients demonstrated enhanced intramolecular epitope spreading compared with baseline (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). There were no complete responses, one partial response (6%), and eight patients with stable disease (47%), for a disease control rate of 53%. The median survival for those with progressive disease was 20.5 months and for responders (PR+SD) was 45.0 months.&lt;/p&gt;Conclusions:&lt;p&gt;Adoptive transfer of HER2 vaccine–primed T cells was feasible, was associated with minimal toxicity, and resulted in an increased overall survival in responding patients.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-23-1244" target="_blank"&gt;See related commentary by Crosby et al., p. 3256&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans (2017)

Organic compounds from plants are an attractive alternative to conventional antimicrobial agents. Therefore, two compounds namely M-1 and M-2 were purified from Origanum vulgare L. and were identified as carvacrol and thymol, respectively. Antimicrobial and antibiofilm activities of these compounds along with chlorhexidine digluconate using various assays was determined against dental caries causing bacteria Streptococcus mutans. The IC<sub>50</sub> values of carvacrol (M-1) and thymol (M-2) against S. mutans were 65 and 54 µg/ml, respectively. Live and dead staining and the MTT assays reveal that a concentration of 100 µg/ml of these compounds reduced the viability and the metabolic activity of S. mutans by more than 50%. Biofilm formation on the surface of polystyrene plates was significantly reduced by M-1 and M-2 at 100 µg/ml as observed under scanning electron microscope and by colorimetric assay. These results were in agreement with RT-PCR studies. Wherein exposure to 25 µg/ml of M-1 and M-2 showed a 2.2 and 2.4-fold increase in Autolysin gene (AtlE) expression level, respectively. While an increase of 1.3 and 1.4 fold was observed in the super oxide dismutase gene (sodA) activity with the same concentrations of M-1 and M-2, respectively. An increase in the ymcA gene and a decrease in the gtfB gene expression levels was observed following the treatment with M-1 and M-2. These results strongly suggest that carvacrol and thymol isolated from O. vulgare L. exhibit good bactericidal and antibiofilm activity against S. mutans and can be used as a green alternative to control dental caries.
Abstract 4151: Mutual feedback activation of PI3K and MAPK pathways support combining inhibitors of the two pathways to enhance efficacy (2010)

Abstract There has been increasing interest in developing cancer therapies targeting PI3K pathway nodes. Unfortunately, the number of tumor types responding to PI3K pathway inhibitors as monotherapy has been limited, since most cancer cells accumulate genetic alterations that result in the constitutive activation of a complex network of proliferation and survival signals. As such, the inhibition of a single survival/proliferation pathway or node within this broader network may be circumvented by constitutive activation (or feedback activation) of an alternative survival pathway, and thus be insufficient for inducing a clinical response. Therefore, in most tumor types, dual pathway inhibition, guided by an in-depth understanding of feedback and cross-talk between pathways, may be required to induce tumor regression. Here we present a nonclinical study exploring mutual feedback activation of MAPK and PI3K pathways. Inhibition of the PI3K pathway by MK-2206 (AKT inhibitor) or MK-8669 (mTOR inhibitor) resulted in feedback activation of MAPK pathway nodes in subsets of lung cell lines. Similarly, inhibition of the MAPK pathway by a MEK inhibitor resulted in feedback activation of the PI3K pathway. Notably, a lack of such feedback activation was associated with sensitivity to the mono inhibitors. The strength of the feedback activation correlated with changes of several receptor tyrosine kinases, suggesting them as a part of the feedback mechanism. Finally, combined inhibition of both MAPK and PI3K pathways synergistically inhibited the feedback activation of both pathways and led to improved in vitro efficacy. Taken together, our findings identify mutual feedback activation of the PI3K and MAPK pathways in response to specific inhibitors and underscore the importance of combined therapeutic approaches with inhibitors to both pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4151.
The General Asymmetric Synthesis of syn‐ and anti‐β‐Substituted Cysteine and Serine Derivatives (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice (2006)

The Th2 cytokines IL-4 and IL-13 mediate allergic pulmonary inflammation and airways hyperreactivity (AHR) in asthma models through signaling dependent upon the IL-4 receptor-alpha chain (IL-4Ralpha). IL-13 has been further implicated in the overproduction of mucus by the airway epithelium and in lung remodeling that commonly accompanies chronic inflammation. IL-4Ralpha-deficient mice are resistant to allergen-induced asthma, highlighting the therapeutic promise of selective molecular inhibitors of IL-4Ralpha. We designed a chemically modified IL-4Ralpha antisense oligonucleotide (IL-4Ralpha ASO) that specifically inhibits IL-4Ralpha protein expression in lung eosinophils, macrophages, dendritic cells, and airway epithelium after inhalation in allergen-challenged mice. Inhalation of IL-4Ralpha ASO attenuated allergen-induced AHR, suppressed airway eosinophilia and neutrophilia, and inhibited production of airway Th2 cytokines and chemokines in previously allergen-primed and -challenged mice. Histologic analysis of lungs from these animals demonstrated reduced goblet cell metaplasia and mucus staining that correlated with inhibition of Muc5AC gene expression in lung tissue. Therapeutic administration of inhaled IL-4Ralpha ASO in chronically allergen-challenged mice produced a spectrum of anti-inflammatory activity similar to that of systemically administered Dexamethasone with the added benefit of reduced airway neutrophilia. These data support the potential utility of a dual IL-4 and IL-13 oligonucleotide inhibitor in allergy/asthma, and suggest that local inhibition of IL-4Ralpha in the lung is sufficient to suppress allergen-induced pulmonary inflammation and AHR.
Toward a disposable low-cost LOC device: heterogeneous polymer micro valve and pump fabricated by UV/ozone-assisted thermal fusion bonding (2020)

Herein, a heterogeneous polymer micro valve and pump with a polypropylene (PP) membrane was developed in a low-cost manner <i>via</i> UV/ozone-assisted thermal fusion bonding. The proposed fabrication technique allowed for a geometrically selective bonding; consequently, the membrane was prevented from bonding with the valve seat of the diaphragm micro-valve, without patterning a protection layer or introducing an additional structure. The developed device withstands 480 kPa of static pressure and up to 350 kPa of a vibration pressure, providing sufficient bonding strength for microfluidic actuations. The fabricated micro valve and pump are fully characterized and compared with a poly(dimethylsiloxane) (PDMS) membrane glass device, showing comparable valving and pumping performance. As a result, the robust PP membrane micro valve and pump are simply implemented in a facile manner, and demonstrated excellent performance, which is highly desirable for mass production of disposable lab-on-a-chip (LOC) devices.
Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain (2015)

Overall, our findings provide proof of concept for a new class of analgesics that target T-type channel deubiquitination.
34.1: Recent Improvements for Applications of Droplet‐Driven Electrowetting Displays [D 3 ] (2009)

Abstract First applications of a new electrowetting display approach have been developed by adt. This technique is environmental friendly because of its bistability (e.g. replacement of LED indicators), and materials used. Those displays are highly suitable for household applications because they appear white in powerless state. Printer‐like subtractive color mixture and high ambient light contrast ratio pave the way towards electronic billboards.
The cluster compiler—a tool for the design of time-triggered real-time systems (1995)

An off-line planning tool that supports the programmer in developing his real-time application is mandatory in the design of time-triggered real-time systems. This paper describes the architecture and the functions of such a tool, the Cluster Compiler, that is in development at our institute. We emphasize on the principle of a strict separation of the local from the global parts of a distributed system and on the consequences for the structure of the design tool arising from this principle.