gebhart/patrepeval huggingface dataset:
Multiplexing of Electrospray Ionization Sources Using Orthogonal Injection into an Electrodynamic Ion Funnel (2021)

In this contribution, we report an efficient approach to multiplex electrospray ionization (ESI) sources for applications in analytical and preparative mass spectrometry. This is achieved using up to four orthogonal injection inlets implemented on the opposite sides of an electrodynamic ion funnel interface. We demonstrate that both the total ion current transmitted through the mass spectrometer and the signal-to-noise ratio increase by 3.8-fold using four inlets compared to one inlet. The performance of the new multiplexing approach was examined using different classes of analytes covering a broad range of mass and ionic charge. A deposition rate of >10 μg of mass-selected ions per day may be achieved by using the multiplexed sources coupled to preparative mass spectrometry. The almost proportional increase in the ion current with the number of ESI inlets observed experimentally is confirmed using gas flow and ion trajectory simulations. The simulations demonstrate a pronounced effect of gas dynamics on the ion trajectories in the ion funnel, indicating that the efficiency of multiplexing strongly depends on gas velocity field. The study presented herein opens up exciting opportunities for the development of bright ion sources, which will advance both analytical and preparative mass spectrometry applications.
The far-infrared reflectivity of liquid Mg–Bi alloys (Extended Abstract) (1977)

not available
TAF1-BD2 in complex with Cpd27 (6-(but-3-en-1-yl)-4-(1-methyl-6-(morpholine-4-carbonyl)-1H-benzo[d]imidazol-4-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) (2018)

The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a potent and selective in vitro tool compound for TAF1(2), starting from a previously reported lead. A cocrystal structure of lead compound 2 bound to TAF1(2) enabled structure-based design and structure-activity-relationship studies that ultimately led to our in vitro tool compound, 27 (GNE-371). Compound 27 binds TAF1(2) with an IC<sub>50</sub> of 10 nM while maintaining excellent selectivity over other bromodomain-family members. Compound 27 is also active in a cellular-TAF1(2) target-engagement assay (IC<sub>50</sub> = 38 nM) and exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by 27 and further supporting the use of 27 in mechanistic and target-validation studies.
Improvement on the Johnson upper bound for error-correcting codes (2003)

Let A(n, d) denote the maximum possible number of codewords in a binary code of length n and minimum Hamming distance d. For large values of n the best known upper bound, for fixed d, is the Johnson bound. We give a new upper bound which is at least as good as the Johnson bound for all values of n and d, and for each d there are infinitely many values of n for which the new bound is better than the Johnson bound.
Pyrolysis Mass Spectrometry: A New Method to Differentiate Between the Mycobacteria of the "Tuberculosis Complex" and Other Mycobacteria (1981)

Pyrolysis mass spectrometry (p.m.s.) was applied to differentiate 91 coded mycobacteria as belonging to either the 'tuberculosis complex' (M. tuberculosis, M. bovis and M. bovis BCG) or to other species of Mycobacterium. Strains were analysed in batches; in each batch three strains each of M. tuberculosis, M. bovis and M. bovis BCG were included as references. Mass spectra were evaluated by computerized multivariate analysis. A 92% positive correlation with classical identification tests was found (2.2% false negative, 5.5% false positive). Approaches for further improvement of this score are indicated. High speed and complete automation of sample analysis, as well as computerized data-processing, make p.m.s. a potential tool for routine application. Sample transfer from peripheral laboratories to a p.m.s. facility is easy, as samples can be sterilized before shipping.
Comparison of the Coracoid, Distal Clavicle, and Scapular Spine for Autograft Augmentation of Glenoid Bone Loss: A Radiologic and Cadaveric Assessment (2022)

With "subcritical" GBL (>13.5%), all autologous bone grafts can be used to adequately restore the bony defect. However, with "critical" GBL (≥20%), only the coracoid and distal clavicle can reliably restore the bony defect.
Two-dimensional phase unwrapping in Doppler Fourier domain optical coherence tomography (2016)

For phase-related imaging modalities using interferometric techniques, it is important to develop effective method to recover phase information that is mathematically wrapped. In this paper, we propose and demonstrate a two-dimensional (2D) method to achieve effective phase unwrapping in Doppler Fourier-domain (FD) optical coherence tomography (OCT), and recover the discontinuous phase distribution in retinal blood flow successfully for the first time in Doppler OCT studies. The proposed method is based on phase gradient approach in the axial dimension, with phase denoising performed through 2D window moving average in the sampled phase image using complex Doppler OCT data. The 2D unwrapping is carried out to correct phase discontinuities in the wrapped Doppler phase map, and the abrupt phase changes can be identified and corrected accurately. The proposed algorithm is computationally efficient and easy to be implemented.
The Future Brake System for India - Optimising Safety and Life Cycle Costs (2003)

&lt;div class="htmlview paragraph"&gt;The current situation and challenge for the future regarding the brake system in India is explained and compared with the history in Europe. The result is a proposal which is based on European experience and technology, however specifically adjusted to the actual needs of India. The solution is a brake system with a more powerful compressor, an air-dryer and an ABS with load proportioning function.&lt;/div&gt;
Microarray‐based IgE serology improves management of severe atopic dermatitis in two children (2016)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Groundwater nitrate pollution risk assessment of the groundwater source field based on the integrated numerical simulations in the unsaturated zone and saturated aquifer (2020)

Groundwater pollution risk assessment in the groundwater source field (GSF) is crucial to ensure groundwater quality safety. A systematic method of assessing groundwater pollution in the GSF was established by combining the numerical models of groundwater flow and solute transport in the vadose zone and aquifer. It is featured by revealing the paramount fate of contaminant from the surface to receptor “well (wells)” via the pathway of vadose zone and aquifers. The method was verified in the phreatic and semi-confined aquifers of a vital GSF, Beijing-Tianjin-Hebei region (BTHR) in China. Nitrate was selected as the model pollutant. The results indicated that the groundwater pollution risk of the phreatic aquifer was dominated by the mediate level (45.27%), and that the second semi-confined aquifer was mainly ranked as relatively low (30.29%) and mediate (38.17%) levels. The groundwater pollution risk maps of the two aquifers were similar. The high and relatively high risk areas were affected by the high intensities of groundwater pollution sources (GPSIs) or short distances from the pollution sources to the pumping well. The low and relatively low risk areas were controlled by low GPSIs and adequate attenuation and denitrification of nitrate in the aquifer. The groundwater pollution risk in the semi-confined aquifer was lower than that in the phreatic aquifer. The groundwater pollution risk mapping provides a valuable scientific reference for the groundwater pollution prevention and control with the focus on the “pollution source” and “groundwater source field”. The proposed method can be further applied to the protections of the GSFs in the BTHR.
Direct retinal projections to GRP neurons in the suprachiasmatic nucleus of the rat (1997)

The retinal projections to gastrin-releasing peptide (GRP)-expressing neurons in the rat suprachiasmatic nucleus (SCN) were investigated by double immunofluorescence and immunoelectron microscopy. Optic nerve terminals labeled by cholera toxin B subunit (CTb) which was transported from the retinal ganglion cells were intermingled with GRP-immunoreactive cell bodies and processes in the ventrolateral portion of the SCN. Ultrastructural analysis revealed that CTb-immunoreactive retinal terminals made synaptic contacts with GRP-immunoreactive dendritic processes. These results demonstrated that photic information is directly input from the optic nerve to GRP neurons in the SCN and these GRP neurons may be involved in circadian entrainment by light.
The Role of HER1-HER4 and EGFRvIII in Hormone-Refractory Prostate Cancer (2006)

These results suggest that the HER family may have multiple roles in prostate cancer, and that expression of the proteins alone is insufficient to predict the biological response that they may elicit.
Exploring the explosive ablation regime of metals in nanosecond micromachining (2000)

We present results of single shot ablation experiments for a variety of metal samples (In, Al, Cu, Mo, W, Ti) using visible, nanosecond lasers at fluences up to approximately 10 4 J cm -2 . At low fluences, usually less than 10 2 J cm -2 , small amounts of material were removed and removal was approximately uniform across the ablation crater. As the fluence increased above approximately 10 2 J cm -2 , substantially more material was removed and a conical pit developed in the center of the ablation crater. The appearance of these conical pits is consistent with material removed by phase explosion mechanisms. In this paper, this ablation phenomenon will be investigated by presenting the crater morphology as a function of fluence. Consequences for micromachining with visible, high repetition rate, nanosecond lasers will be discussed.
A temperature-conditional mutant of simian virus 40 large T antigen requires serum to inhibit myogenesis and does not induce DNA synthesis in myotubes. (1997)

The temperature-conditional mutant tsA58 of SV40 large T antigen (Tag) increases the proliferation rate and the number of cell divisions in primary murine and human myogenic cells when expressed under permissive conditions (i.e., at 33 degrees C in medium containing high levels of serum). Under these conditions, Tag also prevents terminal differentiation. Under nonpermissive conditions (i.e., at 39 degrees C in medium containing low levels of serum) in which Tag is largely inactive, proliferation is arrested, and differentiation occurs. However, even at a permissive temperature, the removal of serum induced myosin expression and the fusion of myogenic cells, which continued to express functional Tag. Although Tag was complexed with pRb, as expected from a functional protein, proliferation was nevertheless arrested, and differentiation was induced. Consistent with these findings, the exposure of Tag-expressing differentiated myotubes to serum at 33 degrees C did not reinduce DNA synthesis in these cells. Thus, in myogenic cells, temperature-conditional mutants of Tag stimulate proliferation in the presence of serum but neither prevent terminal differentiation in the absence of serum nor induce DNA synthesis once complete withdrawal from the cycle has occurred.
Data Fusion in Information Retrieval Using Consensus Aggregation Operators (2008)

In this paper, we address the problem of unsupervised rank aggregation in the context of meta-searching in information retrieval field. The first goal of this paper is to apply aggregation operators that are defined in information fusion domain to the particular issue mentioned beforehand. Triangular norms, conorms and quasi-arithmetic means, are such kind of operators. Then, the second goal of this work is to introduce a new aggregation function, its logical foundations and its combinatorial properties. Particularly, this operator allows to take into account the relationships between experts in a flexible way. Finally, we test these different aggregation operators on the LETOR dataset. The results of our experiments show that this kind of aggregation functions can lead to better results than baseline methods such as CombSUM and CombMNZ approaches.
Spin‐Crossover Materials: Magnetic Susceptibility Study of Sub‐Pico‐emu Sample Using a Micromagnetometer: An Investigation through Bistable Spin‐Crossover Materials (Adv. Mater. 46/2017) (2017)

Spin switching in a nanosized material without an external applied magnetic field can be evidenced using a highly sensitive sub-picoemu magnetometer working at room temperature. In article 1703073, CheolGi Kim, Azzedine Bousseksou, Ferial Terki, and co-workers present an advanced approach based on an induced AC magnetic field and discuss nanoscale magnetic signatures with a resolution of 4 × 10−14 emu at room temperature.
Recent advances in bio‐based epoxy resins and bio‐based epoxy curing agents (2016)

ABSTRACT The combination of awareness of harmful industrial processes and environmental issues and depleting petroleum‐based resources has spurred much research in developing materials from renewable sources. Epoxy resins are common pre‐polymers used in a variety of industries, such as adhesives, coatings, insulations, and high performance composites. To transform epoxy resins into crosslinked networks with desirable thermal and mechanical properties, the resins must be cured with a curing agent. This review encompasses recent developments using bio‐based epoxy resins and bio‐based epoxy curing agents. Resins and curing agents synthesized from modified plant oils, sugars, polyphenols, terpenes, rosin, natural rubber, and lignin are highlighted and their thermal and mechanical properties reviewed. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44103.
Chronic safety assessment of hemostatic self-expanding foam (2015)

Foam treatment was not associated with significant evidence of end-organ dysfunction or toxicity at 28 days or 90 days. Remnant foam particles were well tolerated. These results support the long-term safety of this intervention for severely bleeding patients.
3D Pyrolyzed Carbon Electrodes for Sensing Applications. (2012)

Abstract not provided.
Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric K v 1 channels (2018)

The vast complexity of native heteromeric K<sup>+</sup> channels is largely unexplored. Defining the composition and subunit arrangement of individual subunits in native heteromeric K<sup>+</sup> channels and establishing their physiological roles is experimentally challenging. Here we systematically explored this "zone of ignorance" in molecular neuroscience. Venom components, such as peptide toxins, appear to have evolved to modulate physiologically relevant targets by discriminating among closely related native ion channel complexes. We provide proof-of-principle for this assertion by demonstrating that κM-conotoxin RIIIJ (κM-RIIIJ) from <i>Conus radiatus</i> precisely targets "asymmetric" K<sub>v</sub> channels composed of three K<sub>v</sub>1.2 subunits and one K<sub>v</sub>1.1 or K<sub>v</sub>1.6 subunit with 100-fold higher apparent affinity compared with homomeric K<sub>v</sub>1.2 channels. Our study shows that dorsal root ganglion (DRG) neurons contain at least two major functional K<sub>v</sub>1.2 channel complexes: a heteromer, for which κM-RIIIJ has high affinity, and a putative K<sub>v</sub>1.2 homomer, toward which κM-RIIIJ is less potent. This conclusion was reached by (<i>i</i>) covalent linkage of members of the mammalian Shaker-related K<sub>v</sub>1 family to K<sub>v</sub>1.2 and systematic assessment of the potency of κM-RIIIJ block of heteromeric K<sup>+</sup> channel-mediated currents in heterologous expression systems; (<i>ii</i>) molecular dynamics simulations of asymmetric K<sub>v</sub>1 channels providing insights into the molecular basis of κM-RIIIJ selectivity and potency toward its targets; and (<i>iii</i>) evaluation of calcium responses of a defined population of DRG neurons to κM-RIIIJ. Our study demonstrates that bioactive molecules present in venoms provide essential pharmacological tools that systematically target specific heteromeric K<sub>v</sub> channel complexes that operate in native tissues.
A multifunctional calmodulin‐dependent protein kinase (1983)

Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.
Fusion of regularized femtosecond filaments in air: far field on-axis emission (2016)

The fusion of several coherent 800 nm femtosecond filaments is induced experimentally and numerically by transmitting a beam through a mask with circular apertures followed by the focusing lens. The far-field image of the four-filament fusion region reveals bright on-axis maximum and differs drastically from the diffraction pattern of a low energy beam propagating through the mask in the linear regime. In 3D+time numerical simulations with the carrier wave resolved we show a factor-of-5 saturable growth in the peak plasma density with successive increase in the number of mask openings. An overall spectral blueshift of the fundamental and the third harmonics follows the plasma density increase. The simulated far-field on-axis emission agrees with the experiment and serves as the indication of nonlinear interaction in the fusion region.
HLock+: A Robust and Low-Overhead Logic Locking at the High-Level Language (2022)

With the emergence of the horizontal business model in the semiconductor industry, numerous hardware security concerns have been emerged, including intellectual property (IP) theft, malicious functionality insertion, and IC overproduction. To combat these threats, logic locking has been introduced as one of the most prominent countermeasures, and advances in logic locking have led the most recent techniques toward higher levels of abstractions, i.e., register transfer language (RTL) or high-level languages (C/C++). In this article, we propose HLock+, a robust logic locking framework at the high-level design language. HLock+ consists of two main parts to achieve multiple goals: 1) Locking in HLock+ is based on a formal analysis over design specifications, assets, and critical operations to determine locking points in the design to provide the best solution in terms of desired attack resiliency (e.g., SAT attacks), and locking key size and 2) we integrate the formal analysis with a point function locking technique, in which the locking candidates have been chosen by an optimization algorithm helping us to boost the efficiency of the approach with the given area, power, and performance constraints. Furthermore, the proposed framework ensures a dynamic/automatic locking solution based on a set of specifications, and it is well suited for large-scale designs. Apart from having lesser development/verification efforts, HLock+ at high-level language will be followed by high-level synthesis (HLS) and RTL synthesis, which provides superior uniform distribution and optimum output corruptibility. We show that HLock+ provides potent robustness against de-obfuscation attacks, e.g., SAT and machine-learning-based attacks, while the overhead is kept low.
Abstract 15051: Selective Suppression of Aldosterone Production in Non-Human Primates by SE-6440, a Potent and Highly-Selective Inhibitor of Aldosterone Synthase (CYP11B2) (2018)

Introduction: Primary aldosteronism (PA) is a major public health concern given its prevalence and associated cardiovascular and renal pathology. Compared to patients with essential hypertension, p...
Analysis of Fiber Dispersion Effects on Phase Modulated Signals Using Constellation Diagram (2009)

Effects of CD and first order PMD on the shape of the constellation diagrams of DQPSK systems are presented, and by quantifying variations in the constellation diagrams, a figure of merit is obtained which can be used for computing the amount of dispersion.
ChemInform Abstract: New Aspects of the Catalytic Chemistry of Organolanthanides. Dehydrogenative Coupling of Organotin Hydrides and Octene‐1 Hydrostannylation Catalyzed by Organoyttrium Compounds. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In Vitro Evaluation of Miniaturized Amperometric Enzyme Sensor Based on the Direct Electron Transfer Principle for Continuous Glucose Monitoring (2022)

These results indicate the superb potential of the DET-type FADGDH-based sensor with the combination of a miniaturized integrated electrode. Thus, the described miniaturized DET-type glucose sensor for CGM will be a promising tool for effective glycemic control. This will be further investigated using an in vivo study.
Toward Coactivity (2010)

This paper introduces the concept of Coactivity as a new focal point for Human-Robot Interaction to address the more sophisticated roles of partner or teammate envisioned for future human-robot systems. We propose that most approaches to date have focused on autonomy and suggest that autonomy is the wrong focal point. The envisioned roles, if properly performed, have a high level of interdependence that cannot be addressed solely by autonomy and necessitate a focus on the coactivity.
Selective C-Arylation of Free (NH)-Heteroarenes via Catalytic C−H Bond Functionalization (2003)

A new system for palladium-catalyzed arylation of a broad spectrum of free (NH)-heteroarenes has been developed (indole, pyrrole, pyrazole, 2-phenylimidazole, imidazole, benzimidazole, and purine). Remarkable selectivity has been achieved in the presence of MgO base, providing single C-arylation products, while no N-arylation and no bis-arylation products have been detected. In the case of free imidazole, exclusive C-4 arylation may be switched to exclusive 2-arylation by the addition of CuI to the Pd/Ph3P/MgO system. When free aryl-(NH)-azoles are desired, direct arylation eliminates three steps in comparison to standard methods, including N-protection, stoichiometric metalation or halogenation, and N-deprotection.