gebhart/patrepeval huggingface dataset:
Prospective Randomized Comparison of Standard Hand Pump Infuser Irrigation vs an Automated Irrigation Pump During Percutaneous Nephrolithotomy and Ureteroscopy: Assessment of Operating Room Efficiency and Surgeon Satisfaction (2019)

<b><i>Introduction:</i></b> The objective of this study was to determine if use of an automated irrigation pump (AIP) during ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) affects circulating nurse labor, irrigation-related issues, and surgeon and nurse satisfaction when compared to manual hand pump (HP) irrigation. <b><i>Methods:</i></b> Eighty consecutive adult patients undergoing unilateral URS or PCNL were prospectively randomized to irrigation with the HP or AIP. Preoperative pump setup time, intraoperative pump maintenance time, total pump time (setup+maintenance), and the number of irrigation-related concerns verbalized by the surgeon intraoperatively were recorded; postoperatively, surgeons and nurses rated their satisfaction with the irrigation system (1 = highly dissatisfied to 10 = highly satisfied). <b><i>Results:</i></b> Eighty patients were enrolled (39 AIP and 41 HP); 51 patients underwent URS and 29 patients underwent PCNL. On univariate analysis, the AIP resulted in a significantly reduced total pump time for URS (2.9 <i>vs</i> 5.9 minutes) and PCNL (4.6 <i>vs</i> 33.9 minutes; <i>p</i> < 0.001). The number of irrigation-related concerns was significantly lower in the AIP group during URS (1.2 <i>vs</i> 2.8, <i>p</i> < 0.001), but not during PCNL (1.9 <i>vs</i> 4.0, <i>p</i> = 0.07). The AIP was associated with significantly higher nurse satisfaction during URS (9.2/10 <i>vs</i> 6.5/10, <i>p</i> < 0.001) and PCNL (9.4/10 <i>vs</i> 4.4/10, <i>p</i> = 0.001). There was no significant association between pump type and surgeon satisfaction. On multivariate analysis of URS cases controlling for body mass index and number of stones, use of the AIP was a predictor of total pump time <5 minutes (odds ratio 25.8, 95% confidence interval [CI] 4.0-165.4; <i>p</i> < 0.001) and favorable (8-10/10) nurse satisfaction rating (odds ratio 25.4, 95% CI 4.1-164.0; <i>p</i> < 0.001). Operative time, stone-free rate, and liters of irrigant used with the HP and AIP were similar. <b><i>Conclusions:</i></b> During URS and PCNL, the AIP was associated with a significant reduction in irrigation pump time and higher nurse satisfaction.
New insights on bottom layer thermal stability and laser annealing promises for high performance 3D VLSI (2014)

For the first time the maximum thermal budget of in-situ doped source/drain State Of The Art (SOTA) FDSOI bottom MOSFET transistors is quantified to ensure transistors stability in Sequential 3D (CoolCube™) integration. We highlight no degradation of Ion/Ioff trade-off up to 550°C. Thanks to both metal gate work-function stability especially on short devices and silicide stability improvement, the top MOSFET temperature could be relaxed up to 500°C. Laser anneal is then considered as a promising candidate for junctions activation. Based on in-depth morphological and electrical characterizations it demonstrates very promising results for high performance Sequential 3D integration.
Ketamine Does Not Increase Cerebral Blood Flow Velocity or Intracranial Pressure During Isoflurane/Nitrous Oxide Anesthesia in Patients Undergoing Craniotomy (1996)

MAYBERG, T. S.; LAM, A. M.; MATTA, B. F.; DOMINO, K. B.; WINN, H. R. Author Information
Efficient Enantioselective Synthesis of Functionalized Tetrahydropyrans by Ru-Catalyzed Asymmetric Ring-Opening Metathesis/Cross-Metathesis (AROM/CM) (2004)

An efficient method for enantioselective synthesis of highly functionalized pyrans (up to 98% ee) through Ru-catalyzed asymmetric ring-opening metathesis/cross-metathesis is described. Reactions are promoted by a recyclable chiral Ru-chloride or a new chiral Ru-iodide complex; the latter catalyst is less efficient but gives rise to significantly higher levels of enantioselectivity. Catalytic reactions can be performed in undistilled solvent and with a wide range of substrates, including those that contain secondary and tertiary alcohols. Representative regioselective functionalizations that highlight the utility of the catalytic method are also presented.
CCDC 170720: Experimental Crystal Structure Determination (2001)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
1282: Chronic Cystitis with Urinary Frequency Induced by Continuous Hyperpermeability of Urothelial Layer in Rats (2006)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 23, 2006, 1:00 - 4:00 pm1 Apr 20061282: Chronic Cystitis with Urinary Frequency Induced by Continuous Hyperpermeability of Urothelial Layer in Rats Yukio Hayashi, Atsumi Tamura, Masahito Kawatani, Hiroko Matsuyoshi, Shim Hiragata, Michael B. Chancellor, William C. de Gmat, and Naoki Yoshimura Yukio HayashiYukio Hayashi More articles by this author , Atsumi TamuraAtsumi Tamura More articles by this author , Masahito KawataniMasahito Kawatani More articles by this author , Hiroko MatsuyoshiHiroko Matsuyoshi More articles by this author , Shim HiragataShim Hiragata More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , William C. de GmatWilliam C. de Gmat More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33495-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1282: Chronic Cystitis with Urinary Frequency Induced by Continuous Hyperpermeability of Urothelial Layer in Rats." The Journal of Urology, 175(4S), p. 413 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 413 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Yukio Hayashi More articles by this author Atsumi Tamura More articles by this author Masahito Kawatani More articles by this author Hiroko Matsuyoshi More articles by this author Shim Hiragata More articles by this author Michael B. Chancellor More articles by this author William C. de Gmat More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
Les douleurs de la gonarthrose. Comment les prendre en charge? Que dire à vos patients ? (2020)

La douleur est le principal symptôme qui conduit le patient arthrosique à consulter. Elle est généralement chronique et non linéaire. Sa prise en charge est essentiellement non pharmacologique et multidisciplinaire. Elle doit comprendre de l’information, de l’éducation au patient, une perte de poids si nécessaire, de l’activité physique (y compris des exercices) et une approche cognitivo-comportementale.
Composite Peptide–Agarose Hydrogels for Robust and High-Sensitivity 3D Immunoassays (2022)

Canonical immunoassays rely on highly sensitive and specific capturing of circulating biomarkers by interacting biomolecular baits. In this frame, bioprobe immobilization in spatially discrete three-dimensional (3D) spots onto analytical surfaces by hydrogel encapsulation was shown to provide relevant advantages over conventional two-dimensional (2D) platforms. Yet, the broad application of 3D systems is still hampered by hurdles in matching their straightforward fabrication with optimal functional properties. Herein, we report on a composite hydrogel obtained by combining a self-assembling peptide (namely, Q3 peptide) with low-temperature gelling agarose that is proved to have simple and robust application in the fabrication of microdroplet arrays, overcoming hurdles and limitations commonly associated with 3D hydrogel assays. We demonstrate the real-case scenario feasibility of our 3D system in the profiling of Covid-19 patients' serum IgG immunoreactivity, which showed remarkably improved signal-to-noise ratio over canonical assays in the 2D format and exquisite specificity. Overall, the new two-component hydrogel widens the perspectives of hydrogel-based arrays and represents a step forward towards their routine use in analytical practices.
Infections with enteropathogenic Yersinia species (1998)

Bacteria that infect the body via mucosal surfaces typically display one or more of the following characteristics: (i) colonization and penetration of mucosal epithelia; (ii) evasion of host defences; (iii) multiplication in vivo, and (iv) production of tissue damage. The Gram-negative enteric pathogens, Yersinia enterocolitica and Y. pseudotuberculosis, display all of these to some extent and thus serve as excellent models for the investigation and understanding of bacterial pathogenesis. Several virulence determinants of Y. enterocolitica and Y. pseudotuberculosis have been identified and characterized. These factors act in concert at various stages of the infection to permit bacterial survival and replication in the myriad of environments present in host tissues, including the lumen of the gastrointestinal tract, and the intra- and extracellular compartments of reticulo-endothelial tissues. Expression of many of these virulence determinants is genetically regulated ensuring that they are produced when the bacteria require them. Together, they contribute to the remarkable versatility of Y. enterocolitica and Y. pseudotuberculosis as pathogens. Several of the factors involved in virulence have homologues in other human intestinal pathogens, including Salmonella and Shigella species and diarrhoea-associated strains of Escherichia coli, thus emphasizing the relevance of research into yersiniosis as a means of furthering our understanding of bacterial virulence in general, while providing tantalizing clues to the origin and evolution of bacterial pathogens.
Bringing multi-functionality to tissue scaffolds through deposition of hybrid coating (2018)

Abstract <br/><br/>Introduction<br/>Hybrid coating consists of alternative layers of positively charged chitosan (CS) and negatively charged graphene oxide (GO) has been deposited onto a porous polyurethane (PU) scaffold through an electrostatic layer-by-layer (LbL) assembly technique. The resulting scaffold allows for high photothermal conversion efficiency and pH controlled co-delivery of multiple therapeutic agents. <br/><br/>Methods<br/>PU foam templates were immersed in 1M NaOH solution for 10 mins before dipping in 0.01 M PEI solution to generate a primer layer. The foams were then immersed into GO (2mg/ml) and 0.5 wt% CS solution (in 2% (v/v) acetic acid aqueous solution) alternatively. This procedure was repeated until a desired number of layers were formed. FL (Fluorescein Sodium, 1.2 wt%) loaded GO and MB (Methylene blue, 0.2 mg/ml) loaded CS were used for the preparation of the scaffolds for drug release tests.<br/><br/>Results and Discussion<br/>FL from the coated scaffold shows a pH dependent release (high releases under pH 7.4 and minimal release under pH 4). Whereas MB, shows an opposite trend where drug release was greater under pH4 than pH 7.4. The scaffold also exhibits strong photo-thermal conversion under irradiation of a NIR laser (808nm, 0.15 W) due to the presence of GO. Specifically, the irradiated scaffold surface temperature exceeded 55 °C after 1min of laser irradiation, a temperature range suitable for photothermal cancer therapy. In vitro study confirmed that this multi-functional scaffolds exhibit excellent biocompatibility. <br/><br/>Conclusions<br/>Electrostatic layer-by-layer assembly technique has been successfully deployed to deposit a novel nanoscale GO/CS hybrid coating onto a porous polyurethane scaffold. The coated scaffold is biocompatible and can offer pH-dependent delivery of multiple therapeutic agents as well as on-demand localized photo hyperthermia. It may be potentially used for applications such as cancer photo chemeotherapy. . <br/>
Real-Time Seamless Single Shot 6D Object Pose Prediction (2017)

We propose a single-shot approach for simultaneously detecting an object in an RGB image and predicting its 6D pose without requiring multiple stages or having to examine multiple hypotheses. Unlike a recently proposed single-shot technique for this task (Kehl et al., ICCV'17) that only predicts an approximate 6D pose that must then be refined, ours is accurate enough not to require additional post-processing. As a result, it is much faster - 50 fps on a Titan X (Pascal) GPU - and more suitable for real-time processing. The key component of our method is a new CNN architecture inspired by the YOLO network design that directly predicts the 2D image locations of the projected vertices of the object's 3D bounding box. The object's 6D pose is then estimated using a PnP algorithm. For single object and multiple object pose estimation on the LINEMOD and OCCLUSION datasets, our approach substantially outperforms other recent CNN-based approaches when they are all used without post-processing. During post-processing, a pose refinement step can be used to boost the accuracy of the existing methods, but at 10 fps or less, they are much slower than our method.
OPTIMUM DUTY-CYCLE FOR LOSSY CLASS E AMPLIFIER DEPENDING ON PARASITIC'S TRADE-OFFS (2006)

Class E amplifiers are widely used in microwave (MW) applications due to the high efficiency obtained, theo- retically 100%. This value is realistically limited by losses in the parasitic elements and in the device. Also, as this paper will show, the nonlinearities of the output capacitance of the device influence the maximum achievable efficiency, specially if no additional external shunt capacitor needs to be added (typical in MW). In this paper, an optimum switching duty-cycle is obtained depending on the trade-off of the different loss resistances and the nonlinear effects. Losses in the device are considered both during cutoff and conduction as well as losses in all of the elements. Experimental verification shows good agreement with the proposed theoretical results.
Identification of a Selective Allosteric Agonist of mGlu5 (2013)

Allosteric modulators for G-protein-coupled receptors (GPCRs) provide numerous advantages over orthosteric ligands, including greater sub-type selectivity, reduced receptor desensitization, saturability of effect, and potential for enhanced therapeutic index. Positive allosteric modulators (PAMs) of the group I metabotropic glutamate receptor mGlu5 are being pursued as a novel approach to treat all three symptom domains of schizophrenia. Interestingly, we have noted that mGlu5 PAMs within a single chemotype have the propensity to demonstrate in vitro profiles ranging from pure potentiation, requiring the presence of orthosteric agonist for activation, to robust agonistic activity in the absence of an orthosteric ligand coupled with PAM activity (ago-PAM). Highly selective orthosteric agonists of mGlu5 are not available; additionally, effective agonists of mGlu5 with an allosteric mechanism of activation are not known. Herein we describe the SAR and in vitro profile of a series mGlu5 selective allosteric agonists within an acetylenic picolinamide scaffold. VU0424465 (ML273, SID 125311644/CID 53384845) is the most potent and efficacious ago-PAM within this series and is being declared as a MLPCN probe molecule. ML273 will serve as a significant ago-PAM tool compound for the field with potential for studies within native systems.
Lung morphology assessment by using PETRA sequence at 1.5 Tesla: initial experience in patients (2015)

Poster: ECR 2015 / C-1654 / Lung morphology assessment by using PETRA sequence at 1.5 Tesla: initial experience in patients by: G. Dournes 1, J. Macey1, M. Fayon1, D. Grodzki2, M. Montaudon3, O. Corneloup3, V. Latrabe3, J.-F. Chateil4, F. Laurent3; 1Bordeaux/FR, 2Erlangen/DE, 3Pessac/FR, 4Bordeaux /FR
Using Fourier-Plane Imaging Microscopy for Determining Transition-Dipole-Moment Orientations in Organic Light-Emitting Devices (2020)

We use Fourier-plane imaging microscopy (FIM) to determine the transition-dipole-moment orientation in doped organic emissive thin films. The use of FIM enables precise, sensitive, and rapid measurement of dipole orientation in the emission layer of an organic light-emitting device (OLED). An optical model of a stratified birefringent multilayer is introduced for interpreting results obtained by FIM. Using the model, we determine the average orientation of transition-dipole-moment vectors of three phosphorescent dopant emitters. The dipole alignment measured by FIM quantitatively explains the difference in OLED efficiencies using these archetype dopant molecules. FIM provides a nondestructive tool to measure and ultimately improve the outcoupling efficiency of OLEDs and other light-emitting devices.
DCAFE: A Distributed Cyber Security Automation Framework for Experiments (2014)

Cyber security has quickly become an overwhelming challenge for governments, businesses, private organizations, and individuals. In an increasingly connected world, the trend is for resources to be accessible from anywhere at any time. Greater access to resources implies more targets and potentially a larger surface area for attacks, which makes securing systems more difficult. Automated and semi-automated solutions are needed to keep up with the deluge of modern threats, but designing such systems requires a distributed architecture to support development and testing. Several such architectures exist, but most only focus on providing a platform for running cyber security experiments as opposed to automating experiment processes. In response to this need, we have built a distributed framework based on software agents which can manage system roles, automate data collection, analyze results, and run new experiments without human intervention. The contribution of this work is the creation of a model for experiment automation and control in a distributed system environment, and this paper provides a detailed description of our framework based on that model.
MoS2 Synthesized by Atomic Layer Deposition as Cu Diffusion Barrier (2023)

Abstract Miniaturization in integrated circuits requires that the Cu diffusion barriers located in interconnects between the Cu metal line and the dielectric material should scale down. Replacing the conventional TaN with a 2D transition metal dichalcogenide barrier potentially offers the opportunity to scale to 1–2 nm thick barriers. In this article, it is demonstrated that MoS 2 synthesized by atomic layer deposition (ALD) can be employed as a Cu diffusion barrier. ALD offers a controlled growth process at back‐end‐of‐line (BEOL) compatible temperatures. MoS 2 films of different thicknesses (i.e., 2.2, 4.3, and 6.5 nm) are tested by time‐dependent dielectric breakdown (TDDB) measurements, demonstrating that ALD‐grown MoS 2 can enhance dielectric lifetime by a factor up to 17 at an electric field of 7 MV cm −1 . Extrapolation to lower E‐fields shows that the MoS 2 barriers prepared by ALD have at least an order of magnitude higher median‐time‐to‐failure during device operation at 0.5 MV cm −1 compared with MoS 2 barriers prepared by other methods. By scaling the thickness further down in future work, the ALD MoS 2 films can be applied as ultrathin Cu diffusion barriers.
In vivo imaging of developing mouse embryos using a high-frequency annular-array and chirp-coded excitation. (2009)

High-frequency ultrasound (HFU) offers great potential for in vivo imaging of developing mouse embryos. Nevertheless, mouse-embryo imaging remains challenging because of the random orientation of the embryos and of the limited acoustic penetration depth of HFU. In this study, a 34-MHz, five-element annular array was excited using conventional mono-cycle and chirp-coded excitations. Synthetic focusing and pulse compression (for the chirp excitation) were used to form images with increased depth of field and penetration depth (for the chirp excitation). Three-dimensional (3-D) datasets were acquired from 11-, 12-, and 13-day-old mouse-embryo heads using both excitation schemes and a respiratory-gating algorithm that limited motion artifacts. 3-D reconstructions of the brain ventricles were formed and compared to MRI-based reconstructions. The chirp-based reconstructions were more morphologically accurate than the mono-cycle-based reconstructions. Furthermore, only chirp datasets provided sufficient penetration depth to correctly segment the brain ventricles lying deep inside the mother. Differences between the calculated brain-ventricle volumes obtained using chirp and mono-cycle excitations were as high as 80%. The results of this study suggest that high-frequency chirp-annular-array imaging could become a valuable tool for translational studies and non-invasive efficient phenotyping of the early mouse central nervous system. [Work supported by NIH Grants EB006509 and EB008606.]
Study of adhesion for Cu/Ru(Zn) on dielectrics by an improved four-point bending measurement (2020)

An asymmetric sample preparation method was used in the four-point bending measurement. By using 304 stainless steel with good ductility as lower beam instead of brittle Si, the yield can be increased to more than 75%. It is found that by Ru(Zn) has very good adhesion with the dielectrics because of Zn cooperation. Formation of Zn silicate helps significantly improve the interface adhesion.
Intermediate filament proteins during carcinogenesis and apoptosis (Review). (1999)

The intermediate filament network spreading from the cell periphery to the nucleus forms dynamic linkages between nuclear matrix, actin microfilaments, and the extracellular matrix. The six different types (types I-VI) of IF proteins consisting of nearly 50 different proteins form at least nine different kinds of filaments depending on the tissue types: keratins, lamins, vimentin, desmin, neurofilaments, peripherin, alpha-internexin, glial fibrillary acidic protein and nestin. Their tissue specific expression in normal cells and differential expression/assembly in neoplasia has been of immense value in tumor diagnosis. At the same time, recent in vitro studies point out that keratins, lamins and vimentin are subject to caspase-mediated proteolysis in an apoptosis-related manner. We reviewed the experimentally demonstrated P4-P1 motif specificities of caspases in the selection of substrates in the IF protein family. In addition, we provided clues to possible cleavage of additional IF proteins during programmed cell death, based on acceptable cut site motifs indicated by searches using the PIR protein sequence database. The present review concludes with presentation of evidence on the emerging roles of IFs in association with intermediate filament associated proteins in the dynamic remodeling of the cell during development of neoplastic phenotype and execution of apoptosis.
Enabling hyperpolarized 129Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin (2013)

It is now possible to examine the dynamics and spatial distribution of pulmonary gas uptake by the RBCs of mice using HP (129) Xe MR spectroscopy and imaging. When combined with ventilation imaging, this ability will enable translational "mouse-to-human" studies of impaired gas exchange in a variety of pulmonary diseases.