gebhart/patrepeval huggingface dataset:
Abstract 2491: Nuclear exporter protein XPO1 a novel prognostic and therapeutic target in gastric cancer (2018)

Abstract The high mortality rate associated with Gastric Cancer (GC) indicates the urgent need for actionable therapeutic targets. The nuclear exporter protein exportin 1 (XPO1/CRM1) is the exclusive exporter of many tumor suppressor proteins (TPSs) and growth regulators. XPO1 is often over-expressed in different malignancies leading to aberrant cytoplasmic localization of TSPs and subsequent inactivation. A detailed analysis on the correlation of XPO1 with inflammation-metaplasia-dysplasia-carcinoma sequence progression was performed using immunohistochemistry in 70 GC cases: (a) 10 cases from normal gastric mucosa, (b) 10 cases of stomach with intestinal metaplasia with and without inflammation, (c) 10 cases of mucosa with low-grade dysplasia (d) 10 cases of mucosa with high-grade dysplasia, (e) 10 cases of gastric adenocarcinoma and (f) 20 cases of metastatic gastric carcinoma. A correlation between XPO1 expression, the pathological and clinical features of the disease as well as survival were analyzed. Gastric cancer cell lines were exposed to the Selective Inhibitors of Nuclear Export (SINE) compounds (selinexor, KPT-8602, KPT-185, or the natural agent, leptomycin B (LMB), then analyzed using cytotoxicity and molecular assays. In addition, the activity of selinexor was evaluated in a sub-cutaneous xenograft of gastric cancer cell line NCI-N87. XPO1 served as a prognostic marker for poor outcome as positive staining of XPO1 in GC correlated with aggressive behavior of the disease. Targeting XPO1 using SINE compounds or LMB resulted in inhibition of GC cellular growth (IC50&amp;lt;200 nM), induction of apoptosis and suppression of colony formation (p&amp;lt;0.01). Molecular analysis revealed nuclear retention of several important TSPs, induction of pro-apoptotic proteins and suppression of pro-survival factor Bcl-2. Selinexor given orally at doses of 15 mg/kg twice a week for three weeks caused statistically significant reduction of NCI-N87 tumors in mice (p&amp;lt;0.05). Efficacy studies of SINE compounds in patient derived models of GC are ongoing. Our findings strongly demonstrate the potential of XPO1 to serve not only as a prognostic marker but also as a therapeutic marker in GC that warrants further clinical investigations. Citation Format: Irfana Muqbil, Zaid Mahdi, Rahman Choudhary, Erkan Baloglu, William Senapedis, Yosef Landesman, Sharon Shacham, Michael Kauffman, Steve Kim, Rafic Beydoun, Richard N. Berri, Anthony Shields, Ramzi M. Mohammad, Asfar S. Azmi. Nuclear exporter protein XPO1 a novel prognostic and therapeutic target in gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2491.
Use of Active Surveillance vs Definitive Treatment Among Men With Low- and Favorable Intermediate–Risk Prostate Cancer in the US Between 2010 and 2018 (2023)

This cross-sectional study of data from the Surveillance, Epidemiology and End Results database assesses temporal trends in the use of active surveillance and watchful waiting vs definitive treatment in men with low- and favorable intermediate–risk prostate cancer in the US between 2010 and 2018.
Electron paramagnetic resonance properties ofn-type silicon in the intermediate impurity-concentration range (1975)

The EPR properties of phosphorus-doped silicon are investigated in detail for impurity concentrations $5\ifmmode\times\else\texttimes\fi{}{10}^{16}\ensuremath{\le}{N}_{D}\ensuremath{\le}1.6\ifmmode\times\else\texttimes\fi{}{10}^{18}$ ${\mathrm{d}\mathrm{o}\mathrm{n}\mathrm{o}\mathrm{r}\mathrm{s}/\mathrm{c}\mathrm{m}}^{3}$ and temperatures $1.1\ensuremath{\le}T\ensuremath{\le}35$ K. Particular care is taken to ensure that the inhomogeneously broadened spectra obtained correspond to well-defined experimental "passage cases." Rapid-passage and slow-passage spectra are converted into directly comparable "absorption envelope" forms which are convolutions of Lorentzian spin packets and Gaussian envelope functions. Spin-lattice relaxation times, spin-packet widths, and $g$ values are presented for both the hyperfine and broad-center-line (BCL) components of the spectra. The hyperfine-line spin-packet widths exhibit a concentration dependence and have magnitudes which are larger than those expected from spin-echo measurements of ${T}_{2}$. A previously unreported concentration dependence is also observed for the hyperfine-line $g$ value. Although similar $g$-value and spin-packet-width concentration dependences are noted for the BCL, the BCL parameters exhibit temperature dependences which are distinct from those observed for the corresponding hyperfine-line quantities. A comparison of the fractional spin susceptibility associated with the BCL and the results of a percolation calculation indicates that the BCL can be attributed to clusters of three or more interacting donor atoms. Evidence is also presented for a hyperfine-line spin-lattice relaxation process which proceeds through cross relaxation with fast relaxing cluster (BCL) centers. This process is shown to be consistent with the experimental temperature dependences of the BCL and hyperfine relaxation rates.
Rho Family GTPases Bind to Phosphoinositide Kinases (1995)

Rho family GTPases appear to play an important role in the regulation of the actin cytoskeleton, but the mechanism of regulation is unknown. Since phosphoinositide 3-kinase and phosphatidylinositol 4,5-bisphosphate have also been implicated in actin reorganization, we investigated the possibility that Rho family members interact with phosphoinositide kinases. We found that both GTP- and GDP-bound Rac1 associate with phosphatidylinositol-4-phosphate 5-kinase in vitro and in vivo. Phosphoinositide 3-kinase also bound to Rac1 and Cdc42Hs, and these interactions were GTP-dependent. Stimulation of Swiss 3T3 cells with platelet-derived growth factor induced the association of PI 3-kinase with Rac in immunoprecipitates. PI 3-kinase activity was also detected in Cdc42 immunoprecipitates from COS7 cells. These results suggest that phosphoinositide kinases are involved in Rho family signal transduction pathways and raise the possibility that the effects of Rho family members on the actin cytoskeleton are mediated in part by phosphoinositide kinases.
ChemInform Abstract: Formation and Characterization of the Gallium and Indium Subhydride Molecules Ga2H2 and In2H2: A Matrix Isolation Study. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Etude de l'agitation liée aux vagues dans un bassin portuaire de forme circulaire (2009)

Cette tude est effectue dans le cadre du projet collaboratif MAREVA (MAquette de REalisation Virtuelle des Amnagements portuaires), port par SCE Amnagement & Environnement, labellis par le Ple Gnie Civil Ecoconstruction et soutenu financirement par le Fonds Unique Interministriel. Dans cette note sont abordes les contraintes d'agitation lies aux vagues en relation avec le dveloppement du nouveau concept d'amnagement portuaire brevet BlueRing . Dans sa configuration de base, il s'agit d'un port circulaire avec dans sa partie centrale un puits d'accs un espace souterrain amnag. Sa configuration en symtrie de rvolution, semblable celle du cothon de Carthage, permet l'obtention d'un linaire de quais utiles maximum.
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice (2001)

The scavenger receptor class B type I (SR-BI), which is expressed in the liver and intestine, plays a critical role in cholesterol metabolism in rodents. While hepatic SR-BI expression controls high density lipoprotein (HDL) cholesterol metabolism, intestinal SR-BI has been proposed to facilitate cholesterol absorption. To evaluate further the relevance of SR-BI in the enterohepatic circulation of cholesterol and bile salts, we studied biliary lipid secretion, hepatic sterol content and synthesis, bile acid metabolism, fecal neutral sterol excretion, and intestinal cholesterol absorption in SR-BI knockout mice. SR-BI deficiency selectively impaired biliary cholesterol secretion, without concomitant changes in either biliary bile acid or phospholipid secretion. Hepatic total and unesterified cholesterol contents were slightly increased in SR-BI-deficient mice, while sterol synthesis was not significantly changed. Bile acid pool size and composition, as well as fecal bile acid excretion, were not altered in SR-BI knockout mice. Intestinal cholesterol absorption was somewhat increased and fecal sterol excretion was slightly decreased in SR-BI knockout mice relative to controls. These findings establish the critical role of hepatic SR-BI expression in selectively controlling the utilization of HDL cholesterol for biliary secretion. In contrast, SR-BI expression is not essential for intestinal cholesterol absorption.
Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses (2020)

The liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent years, attention has been directed towards the liver sinusoidal endothelial cells (LSECs), which play a central role in liver innate immunity by their ability to scavenge pathogen- and damage-associated molecular patterns. Every day our bodies are exposed to billions of gut-derived pathogens which must be efficiently removed from the circulation to prevent inflammatory and/or immune reactions in other vascular beds. Here, we have used GFP-labelled Enterobacteria phage T4 (GFP-T4-phage) as a model virus to study the viral scavenging function and metabolism in LSECs. The uptake of GFP-T4-phages was followed in real-time using deconvolution microscopy, and LSEC identity confirmed by visualization of fenestrae using structured illumination microscopy. By combining these imaging modalities with quantitative uptake and inhibition studies of radiolabelled GFP-T4-phages, we demonstrate that the bacteriophages are effectively degraded in the lysosomal compartment. Due to their high ability to take up and degrade circulating bacteriophages the LSECs may act as a primary anti-viral defence mechanism.
Innovative Structural Topology Optimization Approach for Rotordynamics Components Using Innovative Materials and New Manufacturing Techniques (2017)

Topology optimization is an innovative strategy applied in the turbomachinery field with the aim of substantially improving the performances of turbomachinery components in terms of weights, stress levels and rotation speed, with a very remarkable economic impact. Being very flexible, topology optimization allows to manage the structures topology, significantly improving material distribution within a given design space for a given set of loads and boundary conditions. In this paper, the authors, in cooperation with General Electric Nuovo Pignone, develop a new concept design of a turbine disk and the optimized component is compared to the benchmark, in order to verify the achieved improvements. Special attention is paid to the use of innovative materials with lattice structures, characterized by complex three-dimensional geometries. Thanks to advanced technologies, as additive manufacturing, it is now possible to effectively exploit topology optimization to develop new components featured by complex structures. The developed prototypes will be manufactured and tested in the near future together with the industrial partners.
Language virtualization for heterogeneous parallel computing (2010)

As heterogeneous parallel systems become dominant, application developers are being forced to turn to an incompatiblemix of low level programming models (e.g. OpenMP, MPI, CUDA, OpenCL). However, these models do little to shield developers from the difficult problems of parallelization, data decomposition and machine-specific details. Most programmersare having a difficult time using these programming models effectively. To provide a programming modelthat addresses the productivity and performance requirements for the average programmer, we explore a domainspecificapproach to heterogeneous parallel programming. We propose language virtualization as a new principle that enables the construction of highly efficient parallel domain specific languages that are embedded in a common host language. We define criteria for language virtualization and present techniques to achieve them.We present two concrete case studies of domain-specific languages that are implemented using our virtualization approach.
Two-section DBR laser transmitters with accurate channel spacing and fast arbitrary-sequence tuning for optical FDMA networks (1994)

The N-frequency two-section distributed-Bragg-reflector (DBR) Iaser is a promising candidate for use in optical frequency-division multiple-access (FDMA) networks.1 The present design has an active gain section, a Bragg section, and an integrated photodetector in an AT&amp;T ASTROTEC package with a high-efficiency microlens, a built-in thermoelectric cooler, and a solid-state temperature sensor. The laser operates in a single longitudinal rnode with excellent side-mode suppression (&gt;35 dB), offering more than 1 mW of fiber-coupled power with typical bias currents of 50 mA. Figure 1(a) shows the optical frequency as a function of the Bragg current, demonstrating 23 frequency channels spaced equally by approximately 49.8 GHz. The tuning hysteresis effect is small. The channel frequency spacing is inversely proportional to the laser Fabry-Perot cavity length, with a length ≈800 µm for 50-GHz spacing. Thus precise cleaving allows for a matching of the laser channel spacing to a desired value with the same fractional accuracy as the cleave length. We have achieved ±0.5% channel-spacing accuracy for the 50-GHz range. The laser temperature is adjusted ( − 12 GHz/°C) for alignment of the laser modes to standard optical frequency-division-multiplexing (FDM) channel frequencies. Figure 1 (b) shows the frequency offset from channel center. Each mode spans a frequency band ~4-6 GHz wide.
Coated Porous Carbon Cathodes for Lithium Ion Batteries (2008)

Coated porous carbons for cathodes in automotive lithium batteries are being developed with the goal of overcoming the problems with capacity fade and poor thermal management in conventional polymer-bonded cathodes. The active cathode material (lithium iron phosphate nanoparticles) is carbon-bonded to the porous carbon support material. Cathodes have been developed with high specific energy and power and with good cycling behavior.
Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models (2018)

Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio of proinflammatory M1 (classically activated) macrophages to anti-inflammatory M2 (alternatively activated). To decrease the inflammatory activity, we locally delivered the C-C motif chemokine ligand 2 (CCL2) using controlled-release microparticles (MPs). CCL2 is known to promote chemotaxis of M0 or M2 phenotype macrophages to the inflamed site and induce M2 phenotype polarization locally. Our in vitro data showed that CCL2 increased the number of M2 phenotype macrophages, decreased TNF-α secretion, and enhanced chemotaxis of RAW264.7 cells toward CCL2 MPs. Moreover, we induced periodontal disease in 2 animal models through inoculation of Porphyromonas gingivalis and ligature around the murine molar. Micro-computed tomography analysis showed significant reduction of alveolar bone loss in the CCL2 MP treatment group when compared with a blank MP group and a no-treatment periodontitis group in both models. Immunohistologic analysis showed a significant increase in the M2 phenotype subset and a decrease in the M1 phenotype subset in the CCL2 MP group of the P. gingivalis-induced model. Also, in both models, tartrate-resistant acidic phosphatase staining showed significantly fewer numbers of osteoclasts in the CCL2 MP group in alveolar bone area. Moreover, quantitative polymerase chain reaction results showed a significant increase in IL-1RA (interleukin 1 receptor antagonist) mRNA expression and a decrease in RANKL (receptor activator of nuclear factor kappa-Β ligand) mRNA expression in the CCL2 MP group in the ligature model. In summary, manipulation of endogenous M2 phenotype macrophages with CCL2 MPs decreased the M1 phenotype:M2 phenotype ratio and prevented alveolar bone loss in mouse periodontitis models. The delivery of CCL2 MPs provides a novel approach to treat periodontal disease.
Aortoiliac Occlusive Disease in Patients with Known or Suspected Peripheral Vascular Disease: Safety and Efficacy of Gadofosveset-enhanced MR Angiography—Multicenter Comparative Phase III Study (2005)

On the basis of substantial improvements over non-contrast MR angiography in efficacy and a minimal and transient side-effect profile, gadofosveset was found to be safe and effective for MR angiography in patients known or suspected to have peripheral vascular disease.
The relationship between anxiety about prostate cancer among patients with biochemical cancer recurrence and the use of complementary and alternative medicines, diet, and exercise (2017)

<h3>Objective</h3> We aimed to explore associations between anxiety and specific health behaviors such as complementary and alternative medicine (CAM), diet, and exercise among prostate cancer patients. <h3>Methods</h3> PCa patients enrolled in a prospective cohort study of men with biochemical cancer recurrence were surveyed about use of CAM, diet, and exercise. Anxiety was measured with the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the anxiety subscale of the Hospital Anxiety and Depression Scale. <h3>Results</h3> Nearly 70% (44 of 67) of the original cohort of patients completed the supplementary CAM survey. The mean age was 68 years. Eighty percent of respondents reported engaging in a relevant health behavior, and 64% reported doing so in direct response to their PCa diagnosis. Overall, the most prevalent specific behaviors were exercising (56%), making dietary changes (50%), taking calcium supplements (41%), and taking vitamin D supplements (39%). Elevated baseline PCa-specific anxiety (MAX-PC score &gt;16) after biochemical cancer recurrence was associated with use of any CAM (<i>P</i>=0.01), use of herbs/supplements (<i>P</i>=0.01), and dietary changes (<i>P</i>=0.04). <h3>Conclusion</h3> PCa patients commonly use CAM, dietary changes, and exercise in response to their diagnosis, and these changes are associated with elevated general and PCa-specific anxiety.
Immune Mechanisms in Thyroid Eye Disease (2008)

Thyroid eye disease (TED) is an inflammatory condition of the orbit closely associated with Graves' disease. During the course of TED, fibrosis can develop around the extraocular muscles, and excess extracellular matrix and fat accumulates in the periorbital space. This dramatic remodeling results in protrusion of the eye, also known as exophthalmos. Current treatments are sometimes effective in alleviating the symptoms of the disease, but there remains a demand for treatments that prevent or reverse the pathological alterations of orbital tissues. Such treatments may become available as a result of research aimed at understanding the mechanism by which Graves' disease leads to specific remodeling of orbital tissues. Recent findings have uncovered the importance of intercellular communication between autoreactive T cells and orbital fibroblasts. When orbital fibroblasts are activated, possibly by Graves' disease-related autoantibodies, they release T cell chemoattractants, initiating an interaction in which these cells activate each other. These interactions ultimately result in fibroblasts expressing extracellular matrix molecules, proliferating and differentiating into myofibroblasts or lipofibroblasts. Although the mechanisms underlying these processes are not completely understood, several currently available therapeutic strategies might interrupt the signaling between B and T cells and fibroblasts, thereby treating the clinical manifestations of TED.
Experiences Deploying an Always-on Farm Network (2017)

Data-driven techniques for agriculture can help farmers reduce waste, increase farm output and ensure sustainability for the environment. The key enabler for such techniques is an always-on connected IoT system that can sense the different characteristics of the farm and generate short-term and long-term actionable insights for the farmer. Yet building such a system is very challenging due to sparse Internet connectivity and lack of reliable power sources. This is further exacerbated by weather variability that stresses the system in numerous ways. We discuss how we built and deployed Farmbeats [6] in the face of these challenges. We hope our experiences will aid researchers who are beginning to explore deployments in farming or other weakly connected, power-starved scenarios, such as construction, oil fields, mining, and others.
Studies of the resonance structure in $D^0 \to K^\mp \pi^\pm \pi^\pm \pi^\mp$ decays (2016)

Amplitude models are constructed to describe the resonance structure of ${D^{0}\to K^{-}π^{+}π^{+}π^{-}}$ and ${D^{0} \to K^{+}π^{-}π^{-}π^{+}}$ decays using $pp$ collision data collected at centre-of-mass energies of 7 and 8 TeV with the LHCb experiment, corresponding to an integrated luminosity of $3.0\mathrm{fb}^{-1}$. The largest contributions to both decay amplitudes are found to come from axial resonances, with decay modes $D^{0} \to a_1(1260)^{+} K^{-}$ and $D^{0} \to K_1(1270/1400)^{+} π^{-}$ being prominent in ${D^{0}\to K^{-}π^{+}π^{+}π^{-}}$ and $D^{0}\to K^{+}π^{-}π^{-}π^{+}$, respectively. Precise measurements of the lineshape parameters and couplings of the $a_1(1260)^{+}$, $K_1(1270)^{-}$ and $K(1460)^{-}$ resonances are made, and a quasi model-independent study of the $K(1460)^{-}$ resonance is performed. The coherence factor of the decays is calculated from the amplitude models to be $R_{K3π} = 0.459\pm 0.010\,(\mathrm{stat}) \pm 0.012\,(\mathrm{syst}) \pm 0.020\,(\mathrm{model})$, which is consistent with direct measurements. These models will be useful in future measurements of the unitary-triangle angle $γ$ and studies of charm mixing and $C\!P$ violation.
Multilayer Electron-Beam Curing of Polymer Dielectric for Electrical Interconnections (1999)

Electron‐beam curing of a low dielectric constant polymer was investigated as an alternative process to conventional thermal curing for microelectronic interconnection applications. Electron‐beam irradiation was used to cross‐link polynorbornene, which was formulated so that no thermal cross‐linking occurred. It was found that the electron‐beam exposure made the polymer solvent resistant, and improved surface planarity in a multilayer structure. Further, it was also shown that electron‐beam curing resulted in films with properties similar to those of thermally treated films. The degree of cross‐linking was estimated. ©2000 The Electrochemical Society