gebhart/patrepeval huggingface dataset:
Figure S4 from Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11 (2023)

&lt;p&gt;Figure S4 shows that radiotherapy and immunotherapy can synergistically induce tumoral ferroptosis&lt;/p&gt;
BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage (2013)

Melanomas arising in SSD skin have higher mutation loads and contain a spectrum of molecular subtypes compared with BRAF- and NRAS-mutant tumors indicating multigene screening approaches and combination therapies may be required for management of these patients.
Supplementary information from E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models (2023)

&lt;p&gt;Supplementary Table legends and Supplementary Figure legends.&lt;/p&gt;
Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimericPseudomonas exotoxin (1994)

Interleukin-4 receptors (IL4R) are present on a wide variety of human cancer cells derived from both hematopoietic and epithelial malignancies. We have targeted IL4R on a human solid tumor xenograft with chimeric proteins composed of human IL4 (hIL4) and 2 different mutant forms of a powerful bacterial toxin, Pseudomonas exotoxin A (PE). The 2 chimeric toxins, termed hIL4-PE4E and hIL4-PE38QQR, showed specific, hIL4R-dependent and dose-dependent antitumor activities. Neither of the chimeric toxins showed antitumor potency when the ADP-ribosylation activity of the toxin was inactivated by mutagenesis. One of the chimeras, hIL4-PE38QQR, caused a complete although transient regression of established solid tumors. These observations indicate that hIL4-PE chimeric proteins should be further evaluated for the treatment of human malignancies.
Safety and Immunogenicity of an Inactivated Recombinant Newcastle Disease Virus Vaccine Expressing SARS-CoV-2 Spike: Interim Results of a Randomised, Placebo-Controlled, Phase 1/2 Trial (2021)

National Vaccine Institute (Thailand), National Research Council (Thailand), Bill & Melinda Gates Foundation, National Institutes of Health (USA).
Biselyngbyaside, isolated from marine cyanobacteria, inhibits osteoclastogenesis and induces apoptosis in mature osteoclasts (2011)

The mass and function of bones depend on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. An inhibitor of osteoclast differentiation and/or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid arthritis, and tumor metastasis into bone. Biselyngbyaside is a recently isolated macrolide compound from marine cyanobacteria Lyngbya sp. that shows wide-spectrum cytotoxicity toward human tumor cell lines. In this study, we investigated the effects of biselyngbyaside on osteoclast differentiation and function. Biselyngbyaside inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in mouse monocytic RAW264 cells and primary bone marrow-derived macrophages at a low concentration. Similarly, biselyngbyaside suppressed osteoblastic cell-mediated osteoclast differentiation in cocultures. In the RANKL-induced signaling pathway, biselyngbyaside inhibited the expression of c-Fos and NFATc1, which are important transcription factors in osteoclast differentiation. In mature osteoclasts, biselyngbyaside decreased resorption-pit formation. Biselyngbyaside also induced apoptosis accompanied by the induction of caspase-3 activation and nuclear condensation, and these effects were negated by the pancaspase inhibitor z-VAD-FMK. Taken together, the present findings indicate that biselyngbyaside suppresses bone resorption via inhibition of osteoclastogenesis and induction of apoptosis. Thus, biselyngbyaside may be useful for the prevention of bone lytic diseases.
Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein (2003)

IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-gamma, TNF-alpha, and IL-1. We report herein that collagen-induced arthritis (CIA) in mice is inhibited by treatment with murine IL-18 binding protein (mIL-18BP). CIA was induced in DBA/1J mice by the injection of bovine type II collagen (CII) in IFA with added Mycobacterium tuberculosis on days 0 and 21. The mice were then treated for 3 wk with PBS or with two doses of mIL-18BP (0.5 and 3 mg/kg) as a fusion protein with the Fc portion of murine IgG1. Both the clinical disease activity scores and the histological scores of joint damage were reduced 50% in mice treated with either dose of mIL-18BP. Proliferation of CII-stimulated spleen and lymph node cells as well as the change in serum levels of IgG1 and IgG2a Ab to collagen between days 21 and 42 were decreased in mice treated with mIL-18BP. The production of IFN-gamma, TNF-alpha, and IL-1beta in cultured spleen cells was reduced by in vivo treatment with low dose, but not high dose, mIL-18BP. FACS analysis showed a slight decrease in NK cells and an increase in CD4(+) T cells in spleens of mice treated with mIL-18BP. The steady state mRNA levels of IFN-gamma, TNF-alpha, and IL-1beta in isolated joints were all decreased in mice treated with both doses of mIL-18BP. The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints.
Corpus-based techniques in the AT&t nextgen synthesis system. (2000)

The AT&T text-to-speech (TTS) synthesis system has been used as a framework for experimenting with a perceptuallyguided data-driven approach to speech synthesis, with primary focus on data-driven elements in the \back end. Statistical training techniques applied to a large corpus are used to make decisions about predicted speech events and selected speech inventory units. Our recent advances in automatic phonetic and prosodic labeling and a new faster harmonic plus noise model (HNM) and unit preselection implementations have signi cantly improved TTS quality and speeded up both development time and runtime.
Author response: Mechanical instability and interfacial energy drive biofilm morphogenesis (2019)

Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
Precise positioning of semiconductor laser cleaves (1985)

The mirrors of a semiconductor laser are usually formed by manually scribing the crystal to induce a cleaved facet. This procedure is adequate for simple lasers where the cleaves do not have to be aligned with any feature on the surface or when the exact length of the laser is not critical. However, there are many devices where the cleave must be aligned with features on the top surface such as a waveguide, electrode, or other integrated optical or electrical component. In addition, the performance of some devices such as cleaved-coupled-cavity (C3) lasers depends critically on the cavity lengths. For these reasons, we have developed a technique for precise positioning of the laser mirror cleaves. This paper describes use of photoelectrochemical (PEC) etching1 of deep narrow grooves into the laser substrate to weaken the crystal along specific lines and induce cleaves along these lines when the wafer is flexed. Our goal was wafer production of C3 lasers with a 40-μm long cavity coupled to a 210-μm long cavity. The two cavities of a C3 laser were held together with a 1-μm thick Au pad on the p side [Fig. 1(a)]. Groove-induced cleaves were used for the end facets as well as the internal facet. An SEM photo of a pair of grooves is shown in Fig. 1(b). Starting from a mask opening of 5μm, grooves 60 μm deep were routinely etched. Straight-walled flat-bottomed grooves [Fig. 1(c)] were etched when a stop-etch layer was used, such as p-type material or a wider band gap semiconductor that was transparent to the incident light.
The i Blood Group Antigen as a Marker for Umbilical Cord Blood-Derived Mesenchymal Stem Cells (2011)

Multipotent mesenchymal stem cells (MSCs) offer great promise for future regenerative and anti-inflammatory therapies. However, there is a lack of methods to quickly and efficiently isolate, characterize, and ex vivo expand desired cell populations for therapeutic purposes. Single markers to identify cell populations have not been characterized; instead, all characterizations rely on panels of functional and phenotypical properties. Glycan epitopes can be used for identifying and isolating specific cell types from heterogeneous populations, on the basis of their cell-type specific expression and prominent cell surface localization. We have now studied in detail the cell surface expression of the blood group i epitope (linear poly-N-acetyllactosamine chain) in umbilical cord blood (UCB)-derived MSCs. We used flow cytometry and mass spectrometric glycan analysis and discovered that linear poly-N-acetyllactosamine structures are expressed in UCB-derived MSCs, but not in cells differentiated from them. We further verified the findings by mass spectrometric glycan analysis. Gene expression analysis indicated that the stem-cell specific expression of the i antigen is determined by β3-N-acetylglucosaminyltransferase 5. The i antigen is a ligand for the galectin family of soluble lectins. We found concomitant cell surface expression of galectin-3, which has been reported to mediate the immunosuppressive effects exerted by MSCs. The i antigen may serve as an endogenous ligand for this immunosuppressive agent in the MSC microenvironment. Based on these findings, we suggest that linear poly-N-acetyllactosamine could be used as a novel UCB-MSC marker either alone or within an array of MSC markers.
NiFe-based Ball-limiting-metallurgy (BLM) for microbumps at 50&#x03BC;m pitch in 3D chip stacks (2013)

In this work, Pb-free microbumps at 50μm pitch with NiFe-based Ball-limiting-metallurgy (BLM) are fabricated and tested. Detailed microstructural analysis has been performed, which shows a uniform thin layer (~0.2μm) of FeSn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Intermetallic Compound (IMC) is formed between the Pb-free solder and NiFe BLM after the first reflow. In comparison, the NiCuSn IMC can grow more than 2μm in microbumps with the conventional Ni BLM or solder-caped Cu pillar after the first reflow. An excessive lateral “thermal-undercut” has been discovered in NiFe BLM structures during solder reflows due to good edge wettability of NiFe. A dual-layer BLM structure is proposed and demonstrated to mitigate the “thermal-undercut”. Moreover, addition of NiFe layer on a micro-Cu pillar structures have been demonstrated and characterized.
High triplet energy host materials for blue phosphorescent organic light-emitting diodes derived from carbazole modified orthophenylene (2014)

Carbazole modified orthophenylene compounds, 9-([1,1′:2′,1′′-terphenyl]-3-yl)carbazole (Cz-Ter), 9-([1,1′:2′,1′′:2′′,1′′′-quaterphenyl]-3-yl)carbazole (Cz-Quat), 9-([1,1′:2′,1′′:2′′,1′′′:2′′′,1′′′′-quinquephenyl]-3-yl)carbazole (Cz-Quin), were synthesized as host materials for blue phosphorescent organic light emitting diodes. The carbazole modified orthophenylene based host materials showed high triplet energy of above 2.90 eV and there was no reduction of triplet energy according to the increase in the number of phenyl units of the orthophenylene moieties. Cz-Ter, Cz-Quat and Cz-Quin showed maximum quantum efficiencies of 16.2%, 17.3% and 20.9% in blue PHOLEDs, respectively.
ZERODUR glass ceramics: design of structures with high mechanical stresses (2008)

Designing highly mechanically loaded structures made of the zero expansion glass ceramic material ZERODUR&reg; means to analyze the stress for the whole loaded surface, considering changes of the stress state occurring over the total lifetime. Strength data are obtained from specimens with small size and relatively short loading duration, making them not directly applicable to the much larger areas that occur in practical cases. This publication gives guidelines for calculating a fracture probability for mirrors and structures on the basis of existing strength data.
Autoxidation of esters. I. Isobutyl acetate (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutoxidation of esters. I. Isobutyl acetateDale E. Van SickleCite this: J. Org. Chem. 1972, 37, 9, 1392–1397Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jo00974a022https://doi.org/10.1021/jo00974a022research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modelling heat transfer during flow through a random packed bed of spheres (2017)

Heat transfer in a random packed bed of monosized iron ore pellets is modelled with both a discrete three-dimensional system of spheres and a continuous Computational Fluid Dynamics (CFD) model. Results show a good agreement between the two models for average values over a cross section of the bed for an even temperature profiles at the inlet. The advantage with the discrete model is that it captures local effects such as decreased heat transfer in sections with low speed. The disadvantage is that it is computationally heavy for larger systems of pellets. If averaged values are sufficient, the CFD model is an attractive alternative that is easy to couple to the physics up- and downstream the packed bed. The good agreement between the discrete and continuous model furthermore indicates that the discrete model may be used also on non-Stokian flow in the transitional region between laminar and turbulent flow, as turbulent effects show little influence of the overall heat transfer rates in the continuous model.
Chemical analysis of high quality rose oil, rose water and rose vinegar from Greece using enantiomeric gas chromatography-mass spectrometry (2008)

Rose, (Rosa damascena Mill.) has been cultivated systematically, for the first time in Greece, during the last 4 years, for the production of rose oil, one of the most expensive essential oils widely used in perfume industry and cosmetology. Roses were cultivated in two areas of Kozani prefecture (West Macedonia, Greece) and the flowers were separated manually from the aerial parts and were hydrodistilled for 3 hours within 6 hours after their collection. The rose oil yield was up to 0.045%. The obtained rose oil was analyzed using GCMS first with a DB-5 column and then with an enantiomeric column b-Dex sm. The main constituent of rose oil was found to be (-)-citronellol with optical purity &gt;99.9%. The high quality rose oil is characterized by the ratio (citronellol+nerol)/geraniol, which must be between 1.2 and 1.3 [1]. In the studied sample the ratio was found to be 1.23. The proportion of phenylethanol, another characteristic value, was 0.97% in the studied sample, while in Bulgarian rose oil it is &lt;0.1% [2]. Rose oil was also obtained after treatment of rose water with NaCl and pentane, according to Greek Pharmacopoeia III [3]. After GCMS analysis of this rose oil, phenylethanol, which is partially soluble to water, was found to be the major compound (31.4%). Rose water and rose vinegar, another product acquired by roses after fermentation of the petals, were treated with XAD4 resin, and the adsorbed compounds were desorbed using diethylether. In both cases, GCMS analysis showed that phenylethanol was again the major compound (86.5% and 52.3% respectively). The superior yield of the rose oil as well as its high quality confirmed the observation of the ancient historian Herodotus about the excellent odor of the roses of Kozani and supports the further exploitation of the rose cultivation in western Macedonia (Greece).
Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case–control analysis replicated across two independent samples (2023)

The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2–5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite case–control study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary: The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research.
Two-stage complex Rosenbrock schemes for stiff systems (2009)

New two-stage Rosenbrock schemes with complex coefficients are proposed for stiff systems of differential equations. The schemes are fourth-order accurate and satisfy enhanced stability requirements. A one-parameter family of L1-stable schemes with coefficients explicitly calculated by formulas involving only fractions and radicals is constructed. A single L2-stable scheme is found in this family. The coefficients of the fourth-order accurate L4-stable scheme previously obtained by P.D Shirkov are refined. Several fourth-order schemes are constructed that are high-order accurate for linear problems and possess the limiting order of L-decay. The schemes proposed are proved to converge. A symbolic computation algorithm is developed that constructs order conditions for multistage Rosenbrock schemes with complex coefficients. This algorithm is used to design the schemes proposed and to obtain fifth-order accurate conditions.
Quantitativein vivoanalysis of the kinematics of carpal bones from three-dimensional CT images using a deformable surface model and a three-dimensional matching technique (2000)

The purpose of this study was to obtain quantitative information of the relative displacements and rotations of the carpal bones during movement of the wrist. Axial helical CT scans were made of the wrists of 11 volunteers. The wrists were imaged in the neutral position with a conventional CT technique, and in 15-20 other postures (flexion-extension, radial-ulnar deviation) with a low-dose technique. A segmentation of the carpal bones was obtained by applying a deformable surface model to the regular-dose scan. Next, each carpal bone, the radius, and ulna in this scan was registered with the corresponding bone in each low-dose scan using a three-dimensional matching technique. A detailed definition of the surfaces of the carpal bones was obtained from the regular-dose scans. The low-dose scans provided sufficient information to obtain an accurate match of each carpal bone with its counterpart in the regular-dose scan. Accurate estimates of the relative positions and orientations of the carpal bones during flexion and deviation were obtained. This quantification will be especially useful when monitoring changes in kinematics before and after operative interventions, like mini-arthrodeses. This technique can also be applied in the quantification of the movement of other bones in the body (e.g., ankle and cortical spine).
Correlation between Ge E′ Centers and Optical Absorption Bands in SiO2:GeO2 Glasses (1996)

Correlations between optical absorptions in ultraviolet and vacuum ultraviolet regions and Ge E ′ centers were examined using 9SiO 2 ·1GeO 2 glasses irradiated with ArF excimer laser light in order to determine the optical absorption bands due to Ge E ′ centers and the oscillator strength. A good correlation between the band peaking at 6.3 eV and Ge E ′ centers was found in the isochronal annealing experiment. The oscillator strength of the 6.3 eV band was determined to be 0.5±0.1 on the assumption of the above correlation. The large oscillator strength of the 6.3 eV band due to Ge E ′ centers is compatible with the Kramers-Kronig mechanism for photoinduced Bragg grating formation.
Parallel Bayesian Active Learning using Dropout for Optimizing High-Speed Channel Equalization (2021)

This work realizes the parallelization of Bayesian Active Learning using Dropout (BAL-DO) and is successfully applied for optimizing equalization settings for high-speed channel receivers (RX). In this paper, parallel BAL-DO can achieve the largest horizontal eye (HEYE) opening and its corresponding equalization setting 12 times faster, on average, than the previously reported sequential BAL-DO. This corresponds to an average of 40–50 times faster than standard exhaustive time-domain simulations. Moreover, the HEYE prediction accuracy across the whole design space is close to 3 times better while using parallelization than sequential BAL-DO. With these outstanding results, parallel BAL-DO dramatically improves the efficiency for RX equalization optimization and greatly reduces the computing resources and time needed.