gebhart/patrepeval huggingface dataset:
Expertise-Based Data Access in Content-Centric Mobile Opportunistic Networks (2014)

In mobile opportunistic networks, most existing research focuses on how to choose appropriate relays to carry and forward data. Although relay selection is an important issue, other issues such as finding content from people with the right expertise are also very important since the ultimate goal of using mobile opportunistic network is to provide the right content to mobile users (nodes). In this paper, we study expertise-based data access in content-centric mobile opportunistic networks, where the objective is to minimize the average query delay given a sequence of queries considering node expertise, node queuing delay and communication delay. To solve this problem, we propose various query forwarding approaches under deterministic and probabilistic expertise models. Specifically, we propose centralized approaches to assign queries based on a modified Dijkstra's shortest path algorithm and distributed approaches in which query forwarding is based on a utility metric. Extensive simulations on both synthetic and realistic traces demonstrate that our solutions outperform existing approaches.
Recording Physics, Design Considerations, and Fabrication of Nanoscale Bit-Patterned Media (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Recording physics, design considerations, and fabrication of bit-patterned magnetic medium for next generation data storage systems is presented. (Co/Pd)<formula formulatype="inline"><tex>$_N$</tex></formula> magnetic multilayers are evaluated as candidates for bit-patterned medium recording layer materials for their high and easily tunable magnetic anisotropy. The optimized patterned multilayers used in this study had coercivities in excess of 12–14 kOe. Bit patterning was accomplished using ion-beam proximity printing, a high-throughput direct write lithography where a large array of ion beamlets shaped by a stencil mask is used to write an arbitrary device pattern. It is found that the nature of magnetization reversal strongly depends on bit edge imperfections and is likely to contribute to switching field distribution. </para>
Supplementary Figure S10 from Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer (2023)

&lt;p&gt;Representative dot plots for data shown in figure 4D-F and additional exhaustion marker analysis of CD8+ T cells in mice bearing SHP2 manipulated 4T1 metastases.&lt;/p&gt;
Micro-structure of Intermetallic Electrodes for Li-ion Batteries : What are the Requirements for Long-term Cycling Stability? (2008)

Micro-structure of Intermetallic Electrodes for Li-ion Batteries : What are the Requirements for Long-term Cycling Stability?
A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing (2018)

We developed a screening assay in which luciferized ID8 expressing OVA was cocultured with transgenic CD8<sup>+</sup> T cells specifically recognizing the model antigen in an H-2b-restricted manner. The assay was screened with a small-molecule library to identify compounds that inhibit or enhance T cell-mediated killing of tumor cells. Erlotinib, an EGFR inhibitor, was the top compound that enhanced T-cell killing of tumor cells. Subsequent experiments with erlotinib and additional EGFR inhibitors validated the screen results. EGFR inhibitors increased both basal and IFNγ-induced MHC class-I presentation, which enhanced recognition and lysis of tumor cell targets by CD8<sup>+</sup> cytotoxic T lymphocytes. The ID8 cell line was also transduced to constitutively express Cas9, and a pooled CRISPR screen, utilizing the same target tumor cell/T-cell assay, identified single-guide (sg)RNAs targeting <i>EGFR</i> that sensitized tumor cells to T cell-mediated killing. Combination of PD-1 blockade with EGFR inhibition showed significant synergistic efficacy in a syngeneic model, further validating EGFR inhibitors as immunomodulatory agents that enhance checkpoint blockade. This assay can be screened in high-throughput with small-molecule libraries and genome-wide CRISPR/Cas9 libraries to identify both compounds and target genes, respectively, that enhance or inhibit T-cell recognition and killing of tumor cells. Retrospective analyses of squamous-cell head and neck cancer (SCCHN) patients treated with the combination of afatinib and pembrolizumab demonstrated a rate of clinical activity exceeding that of each single agent. Prospective clinical trials evaluating the combination of an EGFR inhibitor and PD-1 blockade should be conducted.
Mild Synthesis of Asymmetric 2‘-Carboxyethyl-Substituted Fluoresceins (2008)

Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second resorcinol analogue. In order to avoid an accumulation of symmetric side products, the second step was performed in two substeps: acid-catalyzed formation of a triphenylmethyl intermediate followed by base-catalyzed cyclization which furnished the desired dyes.
Mixing Identities with Ease (2010)

Anonymous credential systems are a key ingredient for a secure and privacy protecting electronic world. In their full-fledged form, they can realize a broad range of requirements of authentication systems. However, these many features result in a complex system that can be difficult to use. In this paper, we aim to make credential systems easier to employ by providing an architecture and high-level specifications for the different components, transactions and features of the identity mixer anonymous credential system. The specifications abstract away the cryptographic details but they are still sufficiently concrete to enable all features. We demonstrate the use of our framework by applying it to an e-cash scenario.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling (2023)

&lt;p&gt;Supplemental Figure S2. Intracellular BMPRIA and p-Smad-1/-5/-8 expression by CD56int and CD56hi NK cells.&lt;/p&gt;
Technical Aspects of Warm Heart Surgery (1991)

Intermittent hypothermic cardioplegia has been adopted as the method of choice for myocardial protection by most surgeons. The most important aspect of this protection is believed to be adequate hypothermia. An alternative technique has been developed, based on the principles of electromechanical arrest and normothermic aerobic perfusion using continuous warm blood cardioplegia. With this method of myocardial protection the heart is maintained at 37 degrees C throughout the operative procedure. The specific technical aspects used shall be described in detail.
Environmental and occupational disorders Abatement of cockroach allergen (Bla g 1) in low-income, urban housing: A randomized controlled trial (2003)

Background: Clinically relevant reductions in exposure to cockroach allergen, an important risk factor for asthma in inner-city households, have proven difficult to achieve in intervention trials. Objective: This study investigated a method for the abatement of cockroach allergen in low-income, urban homes. The goal was to reduce mean Bla g 1 concentrations below the previously proposed thresholds for allergic sensitization and asthma morbidity. Methods: A prerandomized, nonmasked trial with 16 intervention and 15 control homes was conducted. Study inclusion was based on 50 to 500 cockroaches trapped in a 3-day period. The interventions consisted of occupant education, placement of insecticide bait, and professional cleaning. Vacuumed dust and multiple swab samples were collected at 0, 1, 2, 4, and 6 months in intervention homes and at 0 and 6 months in control homes. Room maps containing cockroach and allergen data were used to guide and monitor the interventions. Results: From 0 to 6 months among intervention homes, geometric mean Bla g 1 concentrations (U/g dust) decreased from 633 to 24 on kitchen floors (96% reduction), from 25 to 4.3 on living room floors/sofas (83% reduction), from 46 to 7.3 on bedroom floors (84% reduction), and from 6.1 to 1.0 in bedroom beds (84% reduction). These reductions, with the exception of that on the bedroom floor (P = .06), were statistically significant relative to changes in control homes. Conclusions: Substantial reductions in cockroach allergen levels can be achieved in inner-city homes. In this study, allergen levels were reduced below the sensitization threshold (2 U/g) in beds, arguably the most relevant site for exposure, and below the asthma morbidity threshold (8 U/g) on bedroom floors and living room floors/sofas. The level on kitchen floors, although reduced 96%, remained above the asthma morbidity threshold. Future studies will test the intervention’s effectiveness in asthma prevention trials. (J Allergy Clin Immunol 2003;112:339-45.)
Recent developments in the inhibitors of neuroinflammation and neurodegeneration: inflammatory oxidative enzymes as a drug target (2010)

Extensive studies and patents recently reported in this field suggest that glial inhibitors may soon proceed to clinical trials. However, before glial inhibitors can serve as novel drugs for the treatment of neuroinflammatory disorders, the neurotoxic and neuroprotective effects of glial neuroinflammatory responses need to be better dissected.
OxRRAM-Based Analog in-Memory Computing for Deep Neural Network Inference: A Conductance Variability Study (2021)

Analog in-memory compute (AiMC) is a promising approach to efficiently process deep neural networks (DNNs). Due to its small size and nonvolatility, oxide resistive random access memory (OxRRAM) is being considered as a memory device to map neural network weights in AiMC systems. However, OxRRAM conductance variability can have a severe impact on neural network accuracy. This variability depends on the conductance range, in which the OxRRAM device is programed. In this work, the conductance variability is characterized by a range of operating regimes. Next, the DNN accuracy is determined by applying the measured conductance distributions as noise on the neural network weights during training and inference. The software equivalent accuracy is achieved for only high current compliance values on small data sets. This has implications on the AiMC system, in which this device is intended to be used.
Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein. (1998)

We have previously demonstrated that human granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to a truncated diphtheria toxin (DT388-GMCSF) kills acute myelogenous leukemia (AML) cell lines bearing the GM-CSF receptor. We now report that exposure of malignant cells from 50 different patients with AML for 48 hours in culture to DT388-GMCSF reduces by a median of 1.6 logs (range, 0 to 3.7 logs) the number of leukemic cells capable of forming colonies in semisolid media (leukemic colony-forming cells [CFU-L]) with a median IC50 of 3 x 10(-12) mol/L (range, 5 to >4,000 x 10(-12) mol/L). Furthermore, the cell kill is dependent on the presence of high-affinity GM-CSF receptors on leukemic blasts, because CFU-L from 27 of 28 AML samples expressing > or = 35 GM-CSF receptors per cell were inhibited by the toxin, whereas the colony growth from all 4 leukemic samples (2 AML, 1 acute lymphoblastic leukemia [ALL], and 1 prolymphocytic leukemia [PLL]) that had less than 35 receptors per cell was unaffected by the drug. Sensitivity of CFU-L to DT388-GMCSF was seen regardless of the clinical responsiveness of the patient's leukemia to standard chemotherapy agents. In contrast, clonogenic cells from normal bone marrow formed colonies at near control numbers after exposure to much higher toxin concentrations (4 x 10(-9) mol/L) than those required to kill CFU-L from most patients. Thus, leukemic progenitors isolated directly from the peripheral blood of most AML patients show the same sensitivity to DT388-GMCSF as previously demonstrated for AML cell lines. Under the same conditions of exposure, normal hematopoietic progenitors are relatively unaffected by DT388-GMCSF, suggesting its potential as a therapeutic agent in AML.
Midkine Induces Tumor Cell Proliferation and Binds to a High Affinity Signaling Receptor Associated with JAK Tyrosine Kinases (1998)

The G401 cell line derived from a rhabdoid tumor of the kidney secretes the heparin-binding growth factors midkine and pleiotrophin. Both proteins act as mitogens for diverse cells, but only midkine serves as an autocrine mitogen for G401 tumor cells. We show that midkine specifically binds a protein or complex of molecular mass greater than 200 kDa with high affinity (Kd = 0.07 +/- 0.01 nM). Midkine, but not pleiotrophin, stimulates tyrosine phosphorylation of several cellular proteins with molecular mass of 100, 130, and 200+ kDa. Upon midkine binding, the midkine-receptor complex associates with the Janus tyrosine kinases, JAK1 and JAK2. MK stimulates tyrosine phosphorylation of JAK1, JAK2, and STAT1alpha. Our initial characterization of the midkine receptor suggests that midkine autocrine stimulation of tumor cell proliferation is mediated by a cell-surface receptor which in turn might activate the JAK/STAT pathway.
NADPH Oxidase Activation: A Mechanism of Hypertension-Associated Erectile Dysfunction (2008)

These data suggest that activation of NADPH oxidase is a molecular mechanism for hypertension-associated ED. Apocynin treatment exerted protective effects on erectile function through inhibition of NADPH oxidase activity, thereby reducing oxidative stress in Ang II-infused hypertensive rats. This is the first study to identify the importance of NADPH oxidase in the regulation of erectile function in vivo.
Resonant control for power converters connected to weak and micro grid systems with variant frequency (2016)

Controlled Power Converters are extensively used in industrial applications as they can adapt the electrical energy as required by the application. However, these devices must be properly commutated in order to control voltages and currents. Indeed, power converters are known to be multivariable, coupled, and nonlinear systems; therefore, the control technique needs to be chosen carefully. There are several control techniques reported in the literature for power converters and one of them is the Resonant Control (RC) mainly used on ac based systems. Advantageously, RC guarantees zero steady state error for a sinusoidal reference with a constant frequency and, in addition, it does not need a stationary to rotating reference frame transformation. However, the conventional RC approach requires the exact ac mains frequency value to ensure zero steady state error, being a significant drawback for applications where variable frequency environments are expected. This paper proposes an enhanced RC scheme capable to work under variable frequency scenarios, as in weak and micro grid systems while guaranteeing zero steady state error. The scheme results in a simple algorithm based upon discrete mathematics whose parameters become independent of the ac grid frequency. Results show the feasibility of the proposed approach even under severe ac frequency variations (over 100%) while featuring a stable control loop operation and zero steady state error.
An Iterative Method to Stabilise a Transfer function in the s - and z -Domains (2006)

Stability of the identified model is crucial in simulation and prediction applications. This paper proposes a two step procedure that generates guaranteed stable transfer function models from noisy data. It consists of an unconstrained optimal noise removal step followed by a stable approximation of the possible unstable estimate. The proposed method is applicable to continuous-time as well as discrete-time and multi input, multivariable systems
Magnetic resonance imaging in diagnosis of chronic posterolateral rotatory instability of the elbow. (2003)

Posterolateral rotatory instability of the elbow can be difficult to diagnose and requires a high degree of clinical suspicion. Cases of chronic posterolateral rotatory instability (symptoms present more than 1 year) may be an even more perplexing subgroup. This is a case report of a patient with a 30-year history of intermittent elbow instability. Clinical examination was equivocal, and magnetic resonance imaging was unable to define any ligamentous injury around the elbow. Examination under anesthesia and surgical findings were consistent with complete disruption of the lateral ulnar collateral ligament. The 12-month follow-up after surgical reconstruction showed complete resolution of symptoms. Posterolateral rotatory instability is a diagnosis largely made by examination under anesthesia. A thorough history and a high clinical suspicion are necessary to support the physician's decision to place the patient under anesthesia. Confirmation of a chronic tear of the lateral ulnar collateral ligament of the elbow with magnetic resonance imaging can be difficult and sometimes misleading.
Recombinant activated factor VII in cardiac surgery (2007)

Background and objective: Recombinant activated factor VII (rFVIIa) is a pharmacologic compound approved for the use in patients with congenital or acquired hemophilia and inhibiting antibodies toward factor VIII or IX. In recent years its use has been proposed in surgical patients demonstrating a lifethreatening bleeding, refractory to the standard therapies. The present study is a review of the clinical information available on the use of rFVIIa in cardiac surgery patients. Methods: Current literature was investigated using a Pubmed search with appropriate key words (rFVIIa OR recombinant activated factor VII AND cardiac surgery). Results: 35 articles were found. These are 11 case reports, 12 case series, 5 review articles, 3 retrospective studies, 2 letters to the Editor, and only one prospective, double-blinded, randomized clinical trial (RCT). The majority of the case reports and case series report a beneficial effect of this drug in the treatment of refractory bleeding. Comparative retrospective studies show conflicting results, and the only RCT demonstrate a significant reduction of allogeneic blood products use in patients treated with rFVIIa. No definitive information is available with respect to thromboembolic complications and general safety of this therapy. Conclusions: rFVIIa is a promising agent for intractable bleeding in surgical patients. However, large prospective randomized trials are needed to define efficacy, dose, and potential side-effects.
Candidate Gene Association Study for Diabetic Retinopathy in Persons with Type 2 Diabetes: The Candidate Gene Association Resource (CARe) (2011)

Genes associated with DN, T2D, and vascular diseases do not appear to be consistently associated with DR. A few genetic variants associated with DR, particularly those in SELP and near IDUA, should be investigated in additional DR cohorts.
From yeast to patient neurons and back again: Powerful new discovery platforms (2014)

No disease-modifying therapies are available for synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA). The lack of therapies has been impeded by a paucity of validated drug targets and problematic cell-based model systems. New approaches are therefore needed to identify genes and compounds that directly target the underlying cellular pathologies elicited by the pathological protein, α-synuclein (α-syn). This small, lipid-binding protein impinges on evolutionarily conserved processes such as vesicle trafficking and mitochondrial function. For decades, the genetically tractable, single-cell eukaryote, budding yeast, has been used to study nearly all aspects of cell biology. More recently, yeast has revealed key insights into the underlying cellular pathologies caused by α-syn. The robust cellular toxicity caused by α-syn expression facilitates unbiased high-throughput small-molecule screening. Critically, one must validate the discoveries made in yeast in disease-relevant neuronal models. Here, we describe two recent reports that together establish yeast-to-human discovery platforms for synucleinopathies. In this exemplar, genes and small molecules identified in yeast were validated in patient-derived neurons that present the same cellular phenotypes initially discovered in yeast. On validation, we returned to yeast, where unparalleled genetic approaches facilitated the elucidation of a small molecule's mode of action. This approach enabled the identification and neuronal validation of a previously unknown "druggable" node that interfaces with the underlying, precipitating pathologies caused by α-syn. Such platforms can provide sorely needed leads and fresh ideas for disease-modifying therapy for these devastating diseases.
CSOI: Beyond Silicon-on-Insulator Photonics (2022)

Compound semiconductor on insulator—an emerging, potentially revolutionary platform-is enabling radically new photonic devices with superb functionality.
Application of the stress interaction failure criterion in platelet composite compression molded parts (2021)

Abstract The stress interaction failure criterion was applied to three compression‐molded sheet molding compound (SMC) materials. Two are epoxy‐based compounds with randomly oriented carbon fiber tows, and the third material consists of glass fiber bundles randomly oriented in a vinyl ester resin. The failure surface was built using tensile test results at different orientations with respect to the flow direction, resulting in combined loads in the principal stress coordinate system. Three unknown variables arise from using only tensile strength values. Solving a system of three equations derived from the criterion function and using the failure values obtained from destructively testing at three different orientations, the unknown variables as well as the interaction strength components were determined. Results show good agreement for all three materials. Overprediction was found in some instances, attributed to the effect of fiber orientation distribution in the part, and to the complex interactions of the filled structures. To allow a more direct comparison between predicted and experimental data, the resulting failure surface was translated to the global coordinate system ( σ xx ) and compared to the data derived from destructive tensile tests. Good agreement for all materials was observed, with underprediction noted for some orientations, attributed in part to the equation solving method and the nature of the mesostructures of the composites, where interactions between the tows, resin, mold walls, and fibers are present. The results of this work show that the methodology described permits the development of a failure surface for SMC materials when limited data is available.
Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306 (2022)

jRCTs031180003.
Tissue Inhibitor of Metalloproteinases-3 Promoter Methylation is an Independent Prognostic Factor for Bladder Cancer (2007)

These results suggest that TIMP-3 promoter methylation could be a clinically applicable marker for bladder cancer progression.