gebhart/patrepeval huggingface dataset:
Observation and evaluation of flaked particle behavior in magnetically enhanced reactive ion etching equipment using a dipole ring magnet (2004)

An in situ particle monitoring system using laser light scattering method was installed onto a commercially available radio frequency (rf) plasma oxide-etching tool that is enhanced magnetically using a dipole ring magnet. We observed the behavior of particles that flaked off the deposition film. It can be proven that the flaked particles have different trajectories depending on the magnetic field. When no magnetic field is applied, the flaked particles make a reciprocating motion near the grounded electrode due to the positive charge of flaked particles within the sheath. Alternatively, flaked particles enter the bulk plasma in response to a small gradient of electrical potential near the upper electrode when the magnetic field is active. Particles typically move horizontally with vertical vibration in bulk plasma using a magnetic field. The main force acting on the particles is electrostatic in nature.
Evaluation of Drive Topologies for Macro Scale Synchronous Electrostatic Machines (2020)

Macro scale electrostatic machines have promising characteristics for low speed direct drive applications. However, their medium voltage (7kV) and low current (<; 1A) characteristics provide a unique challenge for power electronics. Models for the semiconductors, electrostatic machine, and magnetic components were combined to perform a simulation-based comparison between the standard two-level voltage and current source inverter topologies. A low current 10 kV JFET super-cascode was modelled based off static and dynamic characterizations for the switch. Inductors were designed for the CSI dc-link and the VSI output filters and the improved generalized steinmetz equation algorithm modeled magnetic core loss. System losses and harmonic content, combined with implementation considerations, form a basis to compare the two inverter topologies. The comparison shows that the current source inverter is a better choice for a variable-speed drive with a wide operating range, especially at higher speeds. The voltage source inverter topology is speed limited due to the resonance between the inductive output-filter and capacitive machine. However, at low speeds, the VSI can provide high efficiency (~90%) over a wide operating range, suitable for “position and hold” applications.
The effect of parallelism of CMUT cells on phase noise for chem/bio sensor applications (2008)

We investigated the effects of electrically connecting multiple microresonators on the frequency noise with a goal to improve the resolution of a chemical sensor based on the capacitive micromachined ultrasonic transducer (CMUT) technology. We fabricated twenty-two 50-MHz CMUTs with varying number of cells and measured the input impedance characteristics. The impedance measurement results show a linear increase in quality factor as the number of cells increases. Further, a phase noise simulation of Colpitts oscillators employing these CMUTs verifies that the phase noise of the oscillator in the 1/f <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> regime are influenced by the quality factor while the phase noise in the white noise regime are primarily affected by the motional impedance. The oscillator based on the CMUT with 1027 cells has 8.8 dB and 11.4 dB lower phase noise than that based on the CMUT with 397 cells at offset frequencies of 1 kHz and 5 MHz, respectively. Therefore, we demonstrated that electrically connecting multiple microresonators is an effective technique to improve the sensor resolution.
Hall effect measurements on epitaxial SmNiO3thin films and implications for antiferromagnetism (2013)

The rare-earth nickelates ($R$NiO${}_{3}$) exhibit interesting phenomena such as unusual antiferromagnetic order at wave vector q $=$ (\textonehalf{}, 0, \textonehalf{}) and a tunable insulator-metal transition that are subjects of active research. Here we present temperature-dependent transport measurements of the resistivity, magnetoresistance, Seebeck coefficient, and Hall coefficient (${R}_{\mathrm{H}}$) of epitaxial SmNiO${}_{3}$ thin films with varying oxygen stoichiometry. We find that from room temperature through the high temperature insulator-metal transition, the Hall coefficient is holelike and the Seebeck coefficient is electronlike. At low temperature the N\'eel transition induces a crossover in the sign of ${R}_{\mathrm{H}}$ to electronlike, similar to the effects of spin density wave formation in metallic systems but here arising in an insulating phase \ensuremath{\sim}200 K below the insulator-metal transition. We propose that antiferromagnetism can be stabilized by band structure even in insulating phases of correlated oxides, such as $R$NiO${}_{3}$, that fall between the limits of strong and weak electron correlation.
Self-Assembly of Gears at a Fluid/Air Interface (2003)

This paper describes a dynamic system-a system that develops order only when dissipating energy-comprising millimeter to centimeter scale gears that self-assemble into a simple machine at a fluid/air interface. The gears are driven externally and indirectly by magnetic interactions; they are made of poly(dimethylsiloxane) (PDMS) or magnetically doped PDMS, and fabricated by soft lithography. Transfer of torque between gears can take place through three different mechanisms: mechanical interaction, hydrodynamic shear, and capillarity/overlap of menisci. Interplay between these forces allows interactions and motions that are not possible with conventional systems of gears.
Polar States in Vanadium Pentafluoride (1970)

First Page
Kit-On-A-Lid-Assays for accessible self-contained cell (2013)

Microscale methods for cell-based assays typically rely on macroscopic reagent handling and fluidic loading protocols that are technically challenging and do not scale with the number of assays favorably. Here, we demonstrate a microfluidic platform technology called ‘‘Kit-On-A-Lid-Assay’’ (KOALA), that enables the creation of self-contained microfluidic cell-based assays, integrating all the steps required to perform cell-based assays. The KOALA platform allows the pre-packaging of reagents, cryopreservation of cell suspensions, thawing of cell suspensions, culture of cells, and operation of whole cell-based assays. The operation of the KOALA platform is user-friendly and consists of bringing together a lid containing the microchannels, and a base containing the pre-packaged reagents, thereby causing fluidic exchange in all the channels simultaneously. We demonstrate that the KOALA cell-based assays can be simply operated from start to finish without any external laboratory equipment.
High Performance SiC-FET "SIAFET" (2000)

A novel high voltage SIC MOS device named SIAFET (Static induction Injected Accumulated FET) is proposed, which has no pn junction in its on-current flow path and has a conductivity modulation by carriers injected from a p+ buried gate. SIAFET with blocking voltage (BV) of 5,500 V and specific on-resistance RonS (without the conductivity modulation) of 57 m62cm2 was designed by using the 6,200 V mesa JTE and was fabricated using 4H-Sic substrates. Its basic operation has been confirmed for the first time and it has been demonstrated that its RonS has been shown to reduce to less than 1/6 by SIAFET action. Although its achieved BV is relatively low (2,030 V and 4,580 V) and its RonS is relatively high (172 m 62 cmz and 387 m 62 cm'), RonS of 4,580V SiC-SIAFET is less than 1/25 that of the theoretical RonS limit of Si-MOSFET for this BV.
Room temperature Sieving of Hydrogen Isotopes Using 2-D Materials (2017)

Hydrogen isotope separation is critical to the DOE’s mission in environmental remediation and nuclear nonproliferation. Isotope separation is also a critical technology for the NNSA, and the ability to perform the separations at room temperature with a relatively small amount of power and space would be a major advancement for their respective missions. Recent work has shown that 2-D materials such as graphene and hexagonal boron nitride can act as an isotopic sieve at room temperature; efficiently separating hydrogen isotopes in water with reported separation ratios of 10:1 for hydrogen: deuterium separation for a single pass. The work performed here suggests that this technique has merit, and furthermore, we are investigating optimization and scale up of the required 2-D material based membranes.
Poly‐Si Thin‐Film Transistors on Polyimide Substrate for 1 mm Diameter Rollable Active‐Matrix Organic Light‐Emitting Diode Display (2021)

Thin‐film transistor (TFT) backplanes on polyimide (PI) substrate are widely used for foldable active‐matrix organic light‐emitting diode (AMOLED) display. The low‐temperature poly‐Si (LTPS) TFTs on PI substrate for AMOLED displays use the inorganic interlayer (ITL) of SiO 2 /SiN x deposited on the poly‐Si. Herein, a flexible ITL, very thin SiNx/organic PI layer stack, is introduced to improve both mechanical flexibility and environmental stability of LTPS TFT backplane on PI substrate. The electrical stabilities of LTPS TFT with various ITLs are studied such as positive bias temperature stress (PBTS) and negative bias temperature stress (NBTS). It is found that the LTPS TFTs are stable under PBTS and/or NBTS. However, the results on mechanical stability depend on the ITL used. The LTPS TFTs with hybrid ITL (SiN x /organic PI) and organic ITL(PI) are stable under mechanical stress because these TFTs have much less strain under mechanical bending because of the low Young's modulus of PI material. In addition, environmental stabilities of the LTPS TFTs with hybrid ITL is stable at 85 °C and 85% humidity in dark. Therefore, the LTPS TFTs with hybrid ITL are very suitable for rollable active matrix displays.
Supplementary Figure 1 from Sangivamycin-like Molecule 6 Exhibits Potent Anti-Multiple Myeloma Activity through Inhibition of Cyclin-Dependent Kinase-9 (2023)

&lt;p&gt;PDF file, 121K, Screening for cytotoxicity of SLM3 in cancer cell lines derived from multiple tumor types.&lt;/p&gt;
Low FT3 serum values are associated with markers of disease severity, evaluated during the acute phase of COVID-19 (2020)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Transient Amaurosis in One Eye With Simultaneous Dilatation of Retinal Veins (1963)

The occurrence of intermittent blindness in one eye associated with coincident and transient dilatation of the retinal veins was recently reported for the first time.<sup>1</sup>Just a few days prior to the publication of this extensively investigated case, I observed a similar phenomenon in a 34-year-old male patient and obtained the stereophotographs which accompany this report. It is interesting that the first two cases of this readily observed phenomenon were recognized independently within such a brief period of time. <h3>Report of Case</h3> The patient had noted transient and often complete loss of vision in his left eye as long as he could remember. There was no history of maternal disease, birth injury, or childhood disease involving the eyes. No other members of the family had similar symptoms, nor was there a family history of migraine headache or other neurologic disease. The patient considered the right eye to be his
X-ray irradiation-induced formation of luminescent silver clusters in nanoporous matrices (2013)

We report the formation of luminescent silver clusters in zeolites by a fast, highly accurate, and controlled activation of silver ions entrapped in sodalite cages of LTA and FAU zeolites using high-brilliance soft X-rays. The activated luminescent samples were investigated by employing a combination of stationary and time-resolved spectroscopic techniques.
Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus. (1992)

The T-cell receptor (TCR) is a multisubunit complex consisting of the clonotypic Ti alpha and beta (or Ti gamma and delta) subunits and the invariant CD3 gamma, CD3 delta, CD3 epsilon, CD3 zeta, and CD3 eta subunits. Herein, we describe an additional product from the CD3 zeta/eta gene locus which we have termed CD3 theta. The cDNA derives from the first seven exons common to CD3 zeta and CD3 eta, 94 base pairs (bp) of the CD3 eta-specific exon 9 and an additional exon 10 encoding the carboxyl-terminal 15 amino acids and the 3'-untranslated region. The expression of CD3 theta is equivalent to that of CD3 eta in tissue distribution and level of expression as judged by RNase protection analysis. Despite the identity of the amino-terminal 121 amino acids of CD3 zeta, CD3 eta, and CD3 theta and an additional 31 amino acids shared between CD3 eta and CD3 theta, transfection of CD3 theta into the CD3 zeta- eta- T-cell hybridoma, MA5.8, failed to restore detectable surface TCR expression in contrast to transfection with CD3 zeta or CD3 eta. Analysis of the CD3 theta protein in transfectants indicated that CD3 theta is associated with the TCR intracellularly. However, unlike with CD3 zeta, Ti alpha-beta chains remain endoglycosidase H sensitive, suggesting a role for the unique COOH-terminal segment of CD3 theta in mediating TCR retention and/or degradation in a pre-Golgi compartment.
The bacteriophage lambda integrase catalytic domain can be modified to act with the regulatory domain as a recombination-competent binary recombinase (2022)

Site-specific recombinase Int mediates integration of the bacteriophage λ genome into the Escherichia coli chromosome. Integration occurs once the Int tetramer, assisted by the integration host factor IHF, forms the intasome, a higher order structure, within which Int, a heterobivalent protein, interacts with two nonhomologous DNA sequences: the core recombination sites and the accessory arm sites. The binding to these sites is mediated by the catalytic C-terminal domain (CTD) and the regulatory N-terminal domain (NTD) of Int, respectively. Within Int, the NTD can activate or inhibit the recombination activity of the CTD depending on whether the NTD is bound to the arm sites. The CTD alone cannot mediate recombination, and even when the NTD and the CTD are mixed together as individual polypeptides, the NTD cannot trigger recombination in the CTD. In this work, we set to determine what modifications can unlock the recombination activity in the CTD alone and how the CTD can be modified to respond to recombination-triggering signals from the NTD. For this, we performed a series of genetic analyses, which showed that a single mutation that stabilizes the CTD on DNA, E174K, allows the CTD to recombine the core DNA sequences. When the NTD is paired with the CTD (E174K) that also bears a short polypeptide from the C terminus of the NTD, the resulting binary Int can recombine arm-bearing substrates. Our results provide insights into the molecular basis of the regulation of the Int activity and suggest how binary recombinases of the integrase type can be engineered.
Supplementary Methods, Figure Legends 1-3 from Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation (2023)

Supplementary Methods, Figure Legends 1-3 from Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation
Tratamiento percutáneo de las fracturas de escafoides (2013)

Las fracturas de escafoides son las más frecuentes de todos los huesos del carpo suponiendo un 60-70% del total. La mayoría de ellas se localizan a nivel de la cintura. Clásicamente, las fracturas no desplazadas se han tratado de manera conservadora durante largos periodos de inmovilización con férulas u ortesis, obteniéndose buenas tasas de consolidación. Una de las alternativas al tratamiento conservador es la osteosíntesis percutánea con tornillo a compresión; técnica que ha demostrado ser efectiva en el tratamiento de este tipo de fracturas obteniendo excelentes tasas de consolidación, con menor tiempo de recuperación y escaso número de complicaciones relacionadas con el acto quirúrgico. El menor tiempo de inmovilización y la rápida reincorporación del paciente a sus actividades cotidianas ha supuesto un auge de este método frente a la decadencia cada vez mayor del tratamiento ortopédico. El objetivo de este artículo es revisar conceptos actuales en la fijación percutánea del escafoides.
A Turing Test for Molecular Generators (2020)

Machine learning approaches promise to accelerate and improve success rates in medicinal chemistry programs by more effectively leveraging available data to guide a molecular design. A key step of an automated computational design algorithm is molecule generation, where the machine is required to design high-quality, drug-like molecules within the appropriate chemical space. Many algorithms have been proposed for molecular generation; however, a challenge is how to assess the validity of the resulting molecules. Here, we report three Turing-inspired tests designed to evaluate the performance of molecular generators. Profound differences were observed between the performance of molecule generators in these tests, highlighting the importance of selection of the appropriate design algorithms for specific circumstances. One molecule generator, based on match molecular pairs, performed excellently against all tests and thus provides a valuable component for machine-driven medicinal chemistry design workflows.
PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies (2020)

PEGylated nanomedicines are known to induce infusion reactions (IRs) that in some cases can be life-threatening. Herein, we report a case study in which a patient with rare mediastinal and intracardiac IgG4-related sclerosing disease received 8 treatments of intravenously administered PEGylated liposomal methylprednisolone-succinate (NSSL-MPS). Due to the ethical requirements to reduce IRs, the patient received a cocktail of premedication including low dose of steroids, acetaminophen and H2 blockers before each infusion. The treatment was well-tolerated in that IRs, complement activation, anti-PEG antibodies and accelerated blood clearance of the PEGylated drug were not detected. Prior to the clinical study, an in vitro panel of assays utilizing blood of healthy donors was used to determine the potential of a PEGylated drug to activate complement system, elicit pro-inflammatory cytokines, damage erythrocytes and affect various components of the blood coagulation system. The overall findings of the in vitro panel were negative and correlated with the results observed in the clinical phase.
Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia (2018)

Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a putative mechanism linking FGR and abnormal trajectory of the developing brain. While the oxytocin system was also found to be impaired following adverse perinatal events, its role in the modulation of neuroinflammation in the developing brain is still unknown. We used a double-hit rat model of perinatal brain injury induced by gestational low protein diet (LPD) and potentiated by postnatal injections of subliminal doses of interleukin-1β (IL1β) and a zebrafish model of neuroinflammation. Effects of the treatment with carbetocin, a selective, long lasting, and brain diffusible oxytocin receptor agonist, have been assessed using a combination of histological, molecular, and functional tools in vivo and in vitro. In the double-hit model, white matter inflammation, deficient myelination, and behavioral deficits have been observed and the oxytocin system was impaired. Early postnatal supplementation with carbetocin alleviated microglial activation at both transcriptional and cellular levels and provided long-term neuroprotection. The central anti-inflammatory effects of carbetocin have been shown in vivo in rat pups and in a zebrafish model of early-life neuroinflammation and reproduced in vitro on stimulated sorted primary microglial cell cultures from rats subjected to LPD. Carbetocin treatment was associated with beneficial effects on myelination, long-term intrinsic brain connectivity and behavior. Targeting oxytocin signaling in the developing brain may be an effective approach to prevent neuroinflammation - induced brain damage of perinatal origin.
Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial (2021)

The efficacy and safety of efpeglenatide appear to be independent of concurrent SGLT2 inhibitor use. These data support combined SGLT2 inhibitor and glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03496298.
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase (2005)

Certain leukocytes release serine proteases that sustain inflammatory processes and cause disease conditions, such as asthma and chronic obstructive pulmonary disease. We identified beta-ketophosphonate 1 (JNJ-10311795; RWJ-355871) as a novel, potent dual inhibitor of neutrophil cathepsin G (K(i) = 38 nm) and mast cell chymase (K(i) = 2.3 nm). The x-ray crystal structures of 1 complexed with human cathepsin G (1.85 A) and human chymase (1.90 A) reveal the molecular basis of the dual inhibition. Ligand 1 occupies the S(1) and S(2) subsites of cathepsin G and chymase similarly, with the 2-naphthyl in S(1), the 1-naphthyl in S(2), and the phosphonate group in a complex network of hydrogen bonds. Surprisingly, however, the carboxamido-N-(naphthalene-2-carboxyl)piperidine group is found to bind in two distinct conformations. In cathepsin G, this group occupies the hydrophobic S(3)/S(4) subsites, whereas in chymase, it does not; rather, it folds onto the 1-naphthyl group of the inhibitor itself. Compound 1 exhibited noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and lipopolysaccharide-induced airway inflammation. In addition to a marked reduction in neutrophil influx, 1 reversed increases in inflammatory mediators interleukin-1alpha, interleukin-1beta, tissue necrosis factor-alpha, and monocyte chemotactic protein-1 in the glycogen model and reversed increases in airway nitric oxide levels in the lipopolysaccharide model. These findings demonstrate that it is possible to inhibit both cathepsin G and chymase with a single molecule and suggest an exciting opportunity in the treatment of asthma and chronic obstructive pulmonary disease.
Evaluation of Cox Fe3-x O 4 cobaltites as ethanol sensing material (2019)

International audience
Association of Transoral Robotic Surgery With Short-term and Long-term Outcomes and Costs of Care in Oropharyngeal Cancer Surgery (2017)

The use of TORS for surgical resection of OPC is increasing in the United States and is associated with significantly lower use of adjuvant chemoradiation, late gastrostomy and tracheostomy dependence, and lower overall treatment-related costs of care. These data have implications for discussions of value in OPC care at a time of health care reform.