MP63-03 PROBE-BASED CONFOCAL LASER ENDOMICROSCOPY DURING TRANSURETHRAL RESECTION OF BLADDER TUMORS IMPROVES THE DIAGNOSTIC ACCURACY AND THERAPEUTIC EFFICACY (2019)

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology III (MP63)1 Apr 2019MP63-03 PROBE-BASED CONFOCAL LASER ENDOMICROSCOPY DURING TRANSURETHRAL RESECTION OF BLADDER TUMORS IMPROVES THE DIAGNOSTIC ACCURACY AND THERAPEUTIC EFFICACY Jongsoo Lee*, Doo Yong Chung, Hyeok Jun Goh, Don Gu Lee, Jin Hyung Jeon, Hyun Ho Han, Ji Eun Heo, Jae Won Park, Young Sig Kim, Dong Hoon Lim, Joong Shik Lee, Rae Cho In, Won Sik Jang, Won Sik Ham, and Young Deuk Choi Jongsoo Lee*Jongsoo Lee* More articles by this author , Doo Yong ChungDoo Yong Chung More articles by this author , Hyeok Jun GohHyeok Jun Goh More articles by this author , Don Gu LeeDon Gu Lee More articles by this author , Jin Hyung JeonJin Hyung Jeon More articles by this author , Hyun Ho HanHyun Ho Han More articles by this author , Ji Eun HeoJi Eun Heo More articles by this author , Jae Won ParkJae Won Park More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , Dong Hoon LimDong Hoon Lim More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Rae Cho InRae Cho In More articles by this author , Won Sik JangWon Sik Jang More articles by this author , Won Sik HamWon Sik Ham More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556846.79866.c7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: To assess the diagnostic accuracy and therapeutic efficacy of probe-based confocal laser endomicroscopy (pCLE), which provides real-time, in vivo histological information during transurethral resection of bladder tumors. METHODS: We performed a prospective study between August 2013 and August 2014. pCLE was carried out on a total of 119 lesions in 75 patients. We analyzed the diagnostic accuracy of pCLE by comparing the confocal image reports with the pathology reports of surgical specimen. Confocal images were interpreted by a single urologist blinded to the pathology reports. The therapeutic efficacy was analyzed by comparing the outcomes in pCLE and non-pCLE groups. RESULTS: In a total of 119 lesions, 23 were benign and 96 were malignant. The detection accuracy for malignant lesions with pCLE was determined with a sensitivity and a positive predictive value (PPV) of 91.7% and 93.6%, respectively. For high-grade versus low-grade bladder cancer, sensitivity and PPV of pCLE were 94.5% and 89.7%, respectively. Distinguishing carcinoma in situ (CIS) from inflammatory lesions was also accurate with sensitivity, specificity, and PPV of 71.4%, 81.3%, and 83.3%, respectively. The Kaplan-Meier curves revealed that the recurrence-free survival rate was significantly higher in the pCLE group than in the non-pCLE group (p=0.031). CONCLUSIONS: Probe-based confocal laser endomicroscopy is a promising method to provide the surgeon during the transurethral resection of a bladder tumor with real-time tumor histology, regardless of the tumor's gross appearance. Furthermore, it may also improve the therapeutic efficacy with longer recurrence-free periods. Source of Funding: None Seoul, Korea, Republic of; Goyang, Korea, Republic of; Gwangju, Korea, Republic of; Seoul, Korea, Republic of; Goyang, Korea, Republic of; Seoul, Korea, Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e897-e897 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jongsoo Lee* More articles by this author Doo Yong Chung More articles by this author Hyeok Jun Goh More articles by this author Don Gu Lee More articles by this author Jin Hyung Jeon More articles by this author Hyun Ho Han More articles by this author Ji Eun Heo More articles by this author Jae Won Park More articles by this author Young Sig Kim More articles by this author Dong Hoon Lim More articles by this author Joong Shik Lee More articles by this author Rae Cho In More articles by this author Won Sik Jang More articles by this author Won Sik Ham More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement PDF downloadLoading ...