gebhart/patrepeval huggingface dataset:
Supplementary Table 1, Figures 1-2 from Association of Wwox with ErbB4 in Breast Cancer (2023)

Supplementary Table 1, Figures 1-2 from Association of Wwox with ErbB4 in Breast Cancer
Dimethylene Spacers in Functionalized Polystyrenes (1988)

Modes of attachment of functional groups to crosslinked polystyrene are discussed (1). Attention is drawn to improved stability and activity of polymer-bound reagents and catalysts incorporating dimethylene spacer between polystyrene aryl and functional group heteroatom, and the simplicity and versatility of their synthesis through high-conversion functional group modifications.
Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol (2017)

To date, there is no periadventitial drug delivery method available in the clinic to prevent restenotic failure of open vascular reconstructions. Resveratrol is a promising anti-restenotic natural drug but subject to low bioavailability when systemically administered. In order to reconcile these two prominent issues, we tested effects of periadventitial delivery of resveratrol on all three major pro-restenotic pathologies including intimal hyperplasia (IH), endothelium impairment, and vessel shrinkage. In a rat carotid injury model, periadventitial delivery of resveratrol either via Pluronic gel (2-week), or polymer sheath (3-month), effectively reduced IH without causing endothelium impairment and vessel shrinkage. In an in vitro model, primary smooth muscle cells (SMCs) were stimulated with elevated transforming growth factor (TGFβ) and its signaling protein Smad3, known contributors to IH. TGFβ/Smad3 up-regulated Kruppel-like factor (KLF5) protein, and SMC de-differentiation which was reversed by KLF5 siRNA. Furthermore, TGFβ/Smad3-stimulated KLF5 production and SMC de-differentiation were blocked by resveratrol via its inhibition of the Akt-mTOR pathway. Concordantly, resveratrol attenuated Akt phosphorylation in injured arteries. Taken together, periadventitial delivery of resveratrol produces durable inhibition of all three pro-restenotic pathologies - a rare feat among existing anti-restenotic methods. Our study suggests a potential anti-restenotic modality of resveratrol application suitable for open surgery.
Fast Transient Micro-Boiling Characterization (2005)

The dynamics of Thermal Ink Jet (TIJ) micro-bubble life cycles is characterized through bubble area measurements for small planar heaters (41 μm × 45 μm). A laser visualization technique is used to measure the bubble area viewed from above. The bubbles are generated in water by 2–4 μs heating pulse and survive for 8–10 μs after the pulse. The bubble life-cycle consists of a short initiation time, fast growth, a period of maximum size, and a rapid collapse. Effect of the power inputs (2–4 W) total energy releases (8.8–13.3 μJ) and operational frequencies of 2–3 kHz is observed. Direct observations of bubble area indicate that bubble initiation time and initial growth rate correlates to the input power. The maximum bubble size and overall longevity correlates to the total energy release.
Islanding and load shedding schemes for captive power plants (1999)

This paper outlines the various schemes adopted for islanding in industrial plants with captive generation in India. Considerations in the design of islanding and load shedding schemes and reliability aspects are described. Major benefits by interfacing with SCADA are briefly given.
Acidic pH Strongly Enhances In Vitro Biofilm Formation by a Subset of Hypervirulent ST-17 Streptococcus agalactiae Strains (2014)

Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a primary colonizer of the anogenital mucosa of up to 40% of healthy women and an important cause of invasive neonatal infections worldwide. Among the 10 known capsular serotypes, GBS type III accounts for 30 to 76% of the cases of neonatal meningitis. In recent years, the ability of GBS to form biofilm attracted attention for its possible role in fitness and virulence. Here, a new in vitro biofilm formation protocol was developed to guarantee more stringent conditions, to better discriminate between strong-, low-, and non-biofilm-forming strains, and to facilitate interpretation of data. This protocol was used to screen the biofilm-forming abilities of 366 GBS clinical isolates from pregnant women and from neonatal infections of different serotypes in relation to medium composition and pH. The results identified a subset of isolates of serotypes III and V that formed strong biofilms under acidic conditions. Importantly, the best biofilm formers belonged to serotype III hypervirulent clone ST-17. Moreover, the abilities of proteinase K to strongly inhibit biofilm formation and to disaggregate mature biofilms suggested that proteins play an essential role in promoting GBS biofilm initiation and contribute to biofilm structural stability.
Cation chromatography with a conductivity detector (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCation chromatography with a conductivity detectorJames S. Fritz, Douglas T. Gjerde, and Rose M. BeckerCite this: Anal. Chem. 1980, 52, 9, 1519–1522Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ac50059a032https://doi.org/10.1021/ac50059a032research-articleACS PublicationsRequest reuse permissionsArticle Views650Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplemental methods, Supplemental tables S1-S3, Supplemental Figure S1-S8 Legends from A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients (2023)

&lt;p&gt;Supplemental methods, Supplemental tables S1-S3, Supplemental Figure S1-S8 Legends. Supplemental methods for IHC of patient TMA, qPCR of patient cDNA, HPLC protocol, and GTPase activity of patient cells. Figure legends for supplemental figures S1-S8 are included. Supplemental table S1 - Patient Characteristics for IHC Microarrays OV1005 and OV8010. Supplemental table S2 - Patient Characteristics for cDNA Microarray. Supplemental table S3 - Ketorolac enantiomer concentration in serum or peritoneal fluids&lt;/p&gt;
Kumada Coupling of Aryl and Vinyl Tosylates under Mild Conditions. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FaceLift: a transparent deep learning framework to beautify urban scenes (2020)

In the area of computer vision, deep learning techniques have recently been used to predict whether urban scenes are likely to be considered beautiful: it turns out that these techniques are able to make accurate predictions. Yet they fall short when it comes to generating actionable insights for urban design. To support urban interventions, one needs to go beyond <i>predicting</i> beauty, and tackle the challenge of <i>recreating</i> beauty. Unfortunately, deep learning techniques have not been designed with that challenge in mind. Given their 'black-box nature', these models cannot be directly used to explain why a particular urban scene is deemed to be beautiful. To partly fix that, we propose a deep learning framework (which we name FaceLift) that is able to both <i>beautify</i> existing urban scenes (Google Street Views) and <i>explain</i> which urban elements make those transformed scenes beautiful. To quantitatively evaluate our framework, we cannot resort to any existing metric (as the research problem at hand has never been tackled before) and need to formulate new ones. These new metrics should ideally capture the presence (or absence) of elements that make urban spaces great. Upon a review of the urban planning literature, we identify <i>five</i> main metrics: walkability, green spaces, openness, landmarks and visual complexity. We find that, across all the five metrics, the beautified scenes meet the expectations set by the literature on what great spaces tend to be made of. This result is further confirmed by a 20-participant expert survey in which FaceLift has been found to be effective in promoting citizen participation. All this suggests that, in the future, as our framework's components are further researched and become better and more sophisticated, it is not hard to imagine technologies that will be able to accurately and efficiently support architects and planners in the design of the spaces we intuitively love.
Antiviral Use in Canadian Children Hospitalized for Influenza (2021)

Influenza antiviral agents were underused in Canadian pediatric hospitals, including among children with high-risk chronic health conditions. Prescribing varied considerably across sites, increased over time, and was associated with patient and hospital-level characteristics. Multifaceted hospital-based interventions are warranted to strengthen adherence to influenza treatment guidelines and antimicrobial stewardship practices.
Supplementary Methods from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population (2023)

&lt;p&gt;PDF - 49K, Description of additional methods and procedures used in the study. Also includes supplementary references.&lt;/p&gt;
Evolution of a microbial acetyltransferase for modification of glyphosate: a novel tolerance strategy (2005)

N-Acetylation is a modification of glyphosate that could potentially be used in transgenic crops, given a suitable acetyltransferase. Weak enzymatic activity (k(cat) = 5 min(-1), K(M) = 1 mM) for N-acetylation of glyphosate was discovered in several strains of Bacillus licheniformis (Weigmann) Chester by screening a microbial collection with a mass spectrometric assay. The parental enzyme conferred no tolerance to glyphosate in any host when expressed as a transgene. Eleven iterations of DNA shuffling resulted in a 7000-fold improvement in catalytic efficiency (k(cat)/K(M)), sufficient for conferring robust tolerance to field rates of glyphosate in transgenic tobacco and maize. In terms of k(cat)/K(M), the native enzyme exhibited weak activity (4-450% of that with glyphosate) with seven of the common amino acids. Evolution of the enzyme towards an improved k(cat)/K(M) for glyphosate resulted in increased activity toward aspartate (40-fold improved k(cat)), but activity with serine and phosphoserine almost completely vanished. No activity was observed among a broad sampling of nucleotides and antibiotics. Improved catalysis with glyphosate coincided with increased thermal stability.
Resonant optical gradient force interaction for nano-imaging and -spectroscopy (2016)

The optical gradient force provides optomechanical interactions, for particle trapping and manipulation, as well as for near-field optical imaging in scanning probe microscopy. Based on recent spectroscopic experiments, its extension and use for a novel form of chemical scanning probe nano-imaging was proposed. Here, we provide the theoretical basis in terms of spectral behavior, resonant enhancement, and distance dependence of the optical gradient force from numerical simulations in a coupled nanoparticle model geometry. We predict an asymmetric line shape of the optical gradient force for molecular electronic or vibrational resonances, corresponding to the real part of the dielectric function of the sample materials. Yet the line shape can become symmetric and absorptive for collective polaritonic excitations. The corresponding magnitudes of the force range from fN to pN, respectively. The distance dependence scales considerably less steeply than simple point dipole model predictions due to multipole effects. The combination of these characteristics of the optical gradient force offers the chance to experimentally distinguish it from competing processes such as thermal expansion induced forces. In addition we provide a perspective for further resonant enhancement and control of optical forces.
Positive-Bias Stress Test on Amorphous In–Ga–Zn–O Thin Film Transistor: Annealing-Temperature Dependence (2014)

We performed constant positive gate bias stress tests on sputter-deposited amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs) fabricated with various annealing conditions. We found that the time evolution of threshold voltage shift (ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) during the stress test exhibits two different behaviors; a power function type and a logarithmic function type. Combining with thermal desorption spectroscopy (TDS), we found that the ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> type changes from the log-function type to the power-function type as H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> desorption increases. The power-function type is attributed to a H-diffusion limited process. As for the log-function type, the magnitude of ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> has correlation with the hysteresis width in a first transfer curve and the desorption amount of H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O and O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> species between 200 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C-300 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C. Hence, it is considered that the traps causing the log-function type ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> are meta-stable states related to O- and/or OH-related weak bonds.
Supplementary Fig 5 from HER2-Mediated Internalization of Cytotoxic Agents in <i>ERBB2</i> Amplified or Mutant Lung Cancers (2023)

&lt;p&gt;Supplementary Fig 5&lt;/p&gt;
Aspergillus fumigatus LaeA-Mediated Phagocytosis Is Associated with a Decreased Hydrophobin Layer (2009)

Aspergillus fumigatus is the causal agent of the life-threatening disease invasive aspergillosis. A. fumigatus laeA deletants, aberrant in toxin biosynthesis and spore development, are decreased in virulence. Among other characteristics, the decreased virulence is associated with increased spore susceptibility to macrophage phagocytosis. Three characteristics, cell wall microbe-associated molecular patterns (MAMPs), secreted metabolites, and rodlet content, thought to be important in macrophage-Aspergillus spore interactions were examined. Flow cytometry analysis of wild-type and DeltalaeA spores did not reveal any differences in surface-accessible MAMPs, including beta-(1,3)-glucan, alpha-mannose, chitin, and other carbohydrate ligands. Blocking experiments with laminarin and mannan supported the conclusion that differences in cell wall carbohydrates were not responsible for enhanced DeltalaeA spore phagocytosis. Aspergillus spores have been reported to secrete metabolites affecting phagocytosis. Neither spent culture exchange, transwell, nor coincubation internalization experiments supported a role for secreted metabolites in the differential uptake of wild-type and DeltalaeA spores. However, sonication assays implicated a role for surface rodlet protein/hydrophobin (RodAp) in differential spore phagocytosis. A possible role of RodAp in enhanced DeltalaeA spore uptake was further assessed by RodAp extraction and quantification, where wild-type spores were found to contain 60% more RodAp than DeltalaeA spores. After removal of the surface rodlet layer, wild-type spores were phagocytosed at similar rates as DeltalaeA spores. We conclude that increased uptake of DeltalaeA resting spores is not associated with changes in secreted metabolite production of this mutant or surface carbohydrate availability but, rather, due to a decrease in the surface RodAp content of DeltalaeA spores. We theorize that RodAp acts as an antiphagocytic molecule, possibly via physicochemical means and/or by impeding MAMP recognition by macrophage receptors.
Improved survivability with multi-layer dynamic routing (1995)

The article deals with the integrated design and analysis of a telecommunications network to achieve specified levels of survivability under various failure modes and conditions. The main goal of the article is: given a criterion for network survivability, develop a unified theory for network planning at different "layers" of the network, and for coordinated restoration methods after a failure. While most of the discussion relates to modern circuit-switching architectures, for completeness, asynchronous transfer mode technology is also considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Understanding the effects of electrochemical parameters on the areal capacitance of electroactive polymers (2014)

A fractional factorial design of experiments allowed us to optimize the areal capacitance of electropolymerized films over 7 variables using a dramatically reduced set of experiments.
The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function (2017)

Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secretion system (T9SS), a complex translocon found only in some species of the <i>Bacteroidetes</i> phylum. T9SS plays two roles, depending on the lifestyle of the bacteria. It provides either a means of movement (called gliding motility) for peace-loving environmental bacteria or a weapon for pathogens. The best-studied members of these two groups are <i>Flavobacterium johnsoniae</i>, a commensal microorganism often found in water and soil, and <i>Porphyromonas gingivalis</i>, a human oral pathogen that is a major causative agent of periodontitis. In <i>P. gingivalis</i> and some other periodontopathogens, T9SS translocates proteins, especially virulence factors, across the outer membrane (OM). Proteins destined for secretion bear a conserved C-terminal domain (CTD) that directs the cargo to the OM translocon. At least 18 proteins are involved in this still enigmatic process, with some engaged in the post-translational modification of T9SS cargo proteins. Upon translocation across the OM, the CTD is removed by a protease with sortase-like activity and an anionic LPS is attached to the newly formed C-terminus. As a result, a cargo protein could be secreted into the extracellular milieu or covalently attached to the bacterial surface. T9SS is regulated by a two-component system; however, the precise environmental signal that triggers it has not been identified. Exploring unknown systems contributing to bacterial virulence is exciting, as it may eventually lead to new therapeutic strategies. During the past decade, the major components of T9SS were identified, as well as hints suggesting the possible mechanism of action. In addition, the list of characterized cargo proteins is constantly growing. The actual structure of the translocon, situated in the OM of bacteria, remains the least explored area; however, new technical approaches and increasing scientific attention have resulted in a growing body of data. Therefore, we present a compact up-to-date review of this topic.
Designing Phage Therapeutics (2010)

Phage therapy is the application of phages to bodies, substances, or environments to effect the biocontrol of pathogenic or nuisance bacteria. To be effective, phages, minimally, must be capable of attaching to bacteria (adsorption), killing those bacteria (usually associated with phage infection), and otherwise surviving (resisting decay) until they achieve attachment and subsequent killing. While a strength of phage therapy is that phages that possess appropriate properties can be chosen from a large diversity of naturally occurring phages, a more rational approach to phage therapy also can include post-isolation manipulation of phages genetically, phenotypically, or in terms of combining different products into a single formulation. Genetic manipulation, especially in these modern times, can involve genetic engineering, though a more traditional approach involves the selection of spontaneously occurring phage mutants during serial transfer protocols. While genetic modification typically is done to give rise to phenotypic changes in phages, phage phenotype alone can also be modified in vitro, prior to phage application for therapeutic purposes, as for the sake of improving phage lethality (such as by linking phage virions to antibacterial chemicals such as chloramphenicol) or survival capabilities (e.g., via virion PEGylation). Finally, phages, both naturally occurring isolates or otherwise modified constructs, can be combined into cocktails which provide collectively enhanced capabilities such as expanded overall host range. Generally these strategies represent different routes towards improving phage therapy formulations and thereby efficacy through informed design.
Five-wavelength integrated DFB laser arrays with quarter-wave-shifted structures (1987)

Five-wavelength integrated DFB laser arrays with quarter-wave-shifted structures, using nonuniform stripe width, have been developed for high-density WDM systems around the 1.3 μm wavelength region for the first time. Each DFB laser of the five-wavelength integrated DFB laser array oscillated at the Bragg wavelength with a side mode suppression ratio of more than 30 dB. Good reproducibility of 50 ± 5 A lasing wavelength separations has been obtained.