gebhart/patrepeval huggingface dataset:
An enantioselective synthesis of (+)-picrasin B, (+)-.DELTA.2-picrasin B, and (+)-quassin from the R-(-) enantiomer of the Wieland-Miescher ketone (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn enantioselective synthesis of (+)-picrasin B, (+)-.DELTA.2-picrasin B, and (+)-quassin from the R-(-) enantiomer of the Wieland-Miescher ketoneMoonsun Kim, Kenji Kawada, Raymond S. Gross, and David S. WattCite this: J. Org. Chem. 1990, 55, 2, 504–511Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00289a023https://doi.org/10.1021/jo00289a023research-articleACS PublicationsRequest reuse permissionsArticle Views951Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
THE NATURAL HISTORY OF PULMONARY HYPERTENSION IN CHILDREN WITH VENTRICULAR SEPTAL DEFECTS ASSESSED BY SERIAL RIGHT-HEART CATHETERIZATION (1961)

The natural history of the pulmonary arterial pressure in 23 children with isolated ventricular septal defects has been evaluated by serial night heart catheterization. In none of the 23 patients was there a significant increase in pulmonary arterial pressure. Eight patients showed a significant decrease. The direction of shunts did not change between procedures, and the clinical status was stable. Our experience correlated well with the majority of institutions. It would appear that the natural course of pulmonary arterial pressure in ventricular septal defect is not commonly one of progressive rise.
Short Communication: Generation of Recombinant Monoclonal Antibodies against an Immunodominant HLA-A*2402-Restricted HIV Type 1 CTL Epitope (2009)

Molecular interaction between the peptide/MHC class I complexes (pMHCs) and T cell receptor (TCR) is fundamental to the effector function of cytotoxic T lymphocytes (CTLs). Monoclonal antibody against pMHC with TCR-like specificity is a possible research tool for the antigen presentation. However, it is notoriously difficult to isolate monoclonal antibodies against pMHCs by the conventional hybridoma technique. To isolate monoclonal antibodies against an immunodominant HIV-1-derived CTL epitope in the nef gene, we panned phage clones from a human scFv phage display library. Eight Nef138-10/HLA-A*24(A24)-specific scFv clones were isolated and two of them (scFv#3 and scFv#27) were selected for further analysis. The clones stained A24-positive cells pulsed with Nef138-10 peptides specifically. We reconstituted humanized immunoglobulin Gs (IgGs) using a baculovirus expression system. Reconstituted IgGs kept the original specificities of the parental scFvs. The dissociation constants were 23 μM and 20 μM by Biacore, respectively. This is the first report of a successful generation of monoclonal antibodies against an HIV-1 CTL epitope loaded on an MHC class I molecule.
Excimer-laser-induced densification in binary silica glasses (1999)

We report that the rate of excimer-laser-induced densification is a strong function of composition in the binary metal-oxide-silica system. The pulsed excimer-laser-induced densification rate is shown to increase with metal-oxide content. A good correlation was found between the densification rate and the relative softness of the glass, as indicated by the annealing temperature. The densification rate for all the glasses was also found to be a strong function of the excimer-laser wavelength in the order 157nm>193nm >248nm .
Palbociclib and fulvestrant act in synergy to modulate central carbon metabolism in breast cancer cells (2018)

Summary Palbociclib, is a selective inhibitor of cyclin-dependent kinases 4 and 6 and used as a first-line treatment for patients with estrogen receptor positive breast cancer. It has been shown that patients have improved progression-free survival when treated in combination with fulvestrant, an estrogen receptor antagonist. However, the mechanisms for this survival advantage are not known. We sought to analyze metabolic and transcriptomic changes in MCF-7 adenocarcinoma breast cancer cells following single and combined treatments to determine if selective metabolic pathways are targeted during combination therapy. Our results showed that individually, the drugs caused metabolic disruption to the same metabolic pathways, however fulvestrant additionally attenuated the pentose phosphate pathway and the production of important coenzymes. A comprehensive effect was observed when the drugs were applied together, confirming the combinatory therapy′s synergism in the cell model. This study highlights the power of merging high-dimensional datasets to unravel mechanisms involved in cancer metabolism and therapy. Highlights ○ First study employing multi-omics to investigate combined therapy on breast cancer cells ○ Fulvestrant attenuates the pentose phosphate pathway and coenzyme production ○ Synergism of palbociclib and fulvestrant was confirmed in vitro ○ Altered key pathways have been identified eTOC Blurb Johnson et al. applied an innovative multi-omics approach to decipher metabolic pathways affected by single versus combination dosing of palbociclib and fulvestrant in estrogen receptor positive breast cancer. Key metabolites and genes were correlated within metabolic pathways and shown to be involved in the drugs′ synergism.
Interference Measurement Scheme for CoMP in LTE-Advanced Downlink (2013)

Coordinated multi-point (CoMP) transmission and reception is considered to be a promising technology to improve the cell-edge user throughput by mitigating the inter-cell interference, and it is expected to be specified in long-term evolution (LTE) Release 11 in 3GPP. For CoMP, the channel state information (CSI) feedback mechanism is a key factor in achieving a better throughput performance gain. This paper proposes two interference measurement schemes for CoMP in the LTE-Advanced downlink. In the proposed schemes, the existing CSI reference signal, which is used for CSI measurement, is fully utilized considering the impact to legacy user equipment, and a sufficient number of configurations for interference measurement resources are established to facilitate operator cell-planning efforts. Based on multi-cell link level and system-level simulations, we also confirm that the proposed schemes achieve an accurate interference measurement for a single transmission point and CoMP operation.
Nonalcoholic fatty liver disease and portal hypertension (2020)

Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from portal hypertension primarily caused by advanced fibrosis and erratic tissue remodeling. However, elevated portal venous pressure has also been detected in experimental models of fatty liver and in human NAFLD when fibrosis is far less advanced and cirrhosis is absent. Early increases in intrahepatic vascular resistance may contribute to the progression of liver disease. Specific pathophenotypes linked to the development of portal hypertension in NAFLD include hepatocellular lipid accumulation and ballooning injury, capillarization of liver sinusoidal endothelial cells, enhanced contractility of hepatic stellate cells, activation of Kupffer cells and pro-inflammatory pathways, adhesion and entrapment of recruited leukocytes, microthrombosis, angiogenesis and perisinusoidal fibrosis. These pathological events are amplified in NAFLD by concomitant visceral obesity, insulin resistance, type 2 diabetes and dysbiosis, promoting aberrant interactions with adipose tissue, skeletal muscle and gut microbiota. Measurement of the hepatic venous pressure gradient by retrograde insertion of a balloon-tipped central vein catheter is the current reference method for predicting outcomes of cirrhosis associated with clinically significant portal hypertension and guiding interventions. This invasive technique is rarely considered in the absence of cirrhosis where currently available clinical, imaging and laboratory correlates of portal hypertension may not reflect early changes in liver hemodynamics. Availability of less invasive but sufficiently sensitive methods for the assessment of portal venous pressure in NAFLD remains therefore an unmet need. Recent efforts to develop new biomarkers and endoscopy-based approaches such as endoscopic ultrasound-guided measurement of portal pressure gradient may help achieve this goal. In addition, cellular and molecular targets are being identified to guide emerging therapies in the prevention and management of portal hypertension.
Coupling the Neural and Physical Dynamics in Rhythmic Movements (1996)

A pair of coupled oscillators simulating a central pattern generator (CPG) interacting with a pendular limb were numerically integrated. The CPG was represented as a van der Pol oscillator and the pendular limb was modeled as a linearized, hybrid spring-pendulum system. The CPG oscillator drove the pendular limb while the pendular limb modulated the frequency of the CPG. Three results were observed. First, sensory feedback influenced the oscillation frequency of the coupled system. The oscillation frequency was lower in the absence of sensory feedback. Moreover, if the muscle gain was decreased, thereby decreasing the oscillation amplitude of the pendular limb and indirectly lowering the effect of sensory feedback, the oscillation frequency decreased monotonically. This is consistent with experimental data (Williamson and Roberts 1986). Second, the CPG output usually led the angular displacement of the pendular limb by a phase of 90 degrees regardless of the length of the limb. Third, the frequency of the coupled system tuned itself to the resonant frequency of the pendular limb. Also, the frequency of the coupled system was highly resistant to changes in the endogenous frequency of the CPG. The results of these simulations support the view that motor behavior emerges from the interaction of the neural dynamics of the nervous system and the physical dynamics of the periphery.
Synthesis and growth of AgGaGeS4, a promising material for the frequency conversion in the mid-IR range (2013)

AgGaGeS4 is a promising non linear crystal for mid-IR laser applications. One presents the two steps of the material preparation, the synthesis of polycrystals and the crystal growth using the Bridgman-Stockbarger technique.
Processing Induced Distinct Charge Carrier Dynamics of Bulky Organic\n Halide Treated Perovskites (2022)

State-of-the-art metal halide perovskite-based photovoltaics often employ\norganic ammonium salts, AX, as a surface passivator, where A is a large organic\ncation and X is a halide. These surface treatments passivate the perovskite by\nforming layered perovskites (e.g., A2PbX4) or by AX itself serving as a surface\npassivation agent on the perovskite photoactive film. It remains unclear\nwhether layered perovskites or AX is the ideal passivator due to an incomplete\nunderstanding of the interfacial impact and resulting photoexcited carrier\ndynamics of AX treatment. In the present study, we use TRPL measurements to\nselectively probe the different interfaces of glass/perovskite/AX to\ndemonstrate the vastly distinct interfacial photoexcited state dynamics with\nthe presence of A2PbX4 or AX. Coupling the TRPL results with X-ray diffraction\nand nanoscale microscopy measurements, we find that the presence of AX not only\npassivates the traps at the surface and the grain boundaries, but also induces\nan {\\alpha}/{\\delta}-FAPbI3 phase mixing that alters the carrier dynamics near\nthe glass/perovskite interface and enhances the photoluminescence quantum\nyield. In contrast, the passivation with A2PbI4 is mostly localized to the\nsurface and grain boundaries near the top surface where the availability of\nPbI2 directly determines the formation of A2PbI4. Such distinct mechanisms\nsignificantly impact the corresponding solar cell performance, and we find AX\npassivation that has not been converted to a layered perovskite allows for a\nmuch larger processing window (e.g., larger allowed variance of AX\nconcentration which is critical for improving the eventual manufacturing yield)\nand more reproducible condition to realize device performance improvements,\nwhile A2PbI4 as a passivator yields a much narrower processing window. We\nexpect these results to enable a more rational route for developing AX for\nperovskite.\n
ChemInform Abstract: Counter‐Ion Effect in the Palladium(0)‐Catalyzed Double Allylation of a 1,5‐Dinucleophile. A Novel Eight‐Membered Ring Synthesis. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Serum Peroxiredoxin 4: A Marker of Oxidative Stress Associated with Mortality in Type 2 Diabetes (ZODIAC-28) (2014)

Prx4 is independently associated with (cardiovascular) mortality in type 2 diabetes patients. After addition of Prx4 to the traditional risk factors, there was a slightly improvement in risk prediction of (cardiovascular) mortality in this patient group.
The Natural History of Adult Crohn's Disease in Population-Based Cohorts (2009)

Crohn's disease is a disabling condition over time. The impact of changing treatment paradigms with increased use of immunosuppressants and biological agents on its natural history is poorly known.
Finger vein authentication system based on capture of moving images (2016)

It is well known that biometric information can provide convenient and reliable user authentication. Recently, the application field of biometric authentication is expanding from small-scale service to wide-scale one such as big event venue, theme park, and so on. In these situations, high-speed calculation and smooth operation are required because of a large number of users. In order to apply finger vein authentication to above services, walkthrough finger vein authentication system [1] has been studied. In our study, we propose a hand waving finger vein authentication system, in which a hand-waving movie is captured with a camera, and a biometric feature is obtained by synthesizing some finger vein patterns extracted from the movie. In this paper, we develop a prototype system of the hand-waving finger vein authentication and evaluate the verification performance of the proposed system.
Simultaneous Enzymatic Synthesis of Gluconic Acid and Sorbitol (1997)

With regard to the enzymatic synthesis of sorbitol and gluconic acid, a screening was carried out to identify promising producers of glucose-fructose oxidoreductase (GFOR) and gluconolactonase (GL). Zymomonas mobilis DSM 473 and Rhodotorula rubra DSM 70403 have been selected for the synthesis of GFOR and GL, respectively. Maximal enzyme production by these organisms has been achieved at D-glucose concentrations of 200 and 150 g/L, respectively. Both GFOR and GL were purified and characterized with respect to some of their catalytic properties. GL showed strict specificity for 1,5-(δ)-lactones and was activated by Mg2+ and Mn2+ ions. The potential use of soluble GFOR is limited by its inactivation during substrate conversion, and the effects of reaction temperature and pH on the “catalytic” stability of GFOR were evaluated. Exogenous adddition of auxiliary GL had no effect on oxidoreductase stability and did not improve productivities.
Understanding and Curing Structural Defects in Colloidal GaAs Nanocrystals (2017)

GaAs is one of the most important semiconductors. However, colloidal GaAs nanocrystals remain largely unexplored because of the difficulties with their synthesis. Traditional synthetic routes either fail to produce pure GaAs phase or result in materials whose optical properties are very different from the behavior expected for quantum dots of direct-gap semiconductors. In this work, we demonstrate a variety of synthetic routes toward crystalline GaAs NCs. By using a combination of Raman, EXAFS, transient absorption, and EPR spectroscopies, we conclude that unusual optical properties of colloidal GaAs NCs can be related to the presence of Ga vacancies and lattice disorder. These defects do not manifest themselves in TEM images and powder X-ray diffraction patterns but are responsible for the lack of absorption features even in apparently crystalline GaAs nanoparticles. We introduce a novel molten salt based annealing approach to alleviate these structural defects and show the emergence of size-dependent excitonic transitions in colloidal GaAs quantum dots.
Planning and learning in permutation groups (1989)

Planning is defined as the problem of synthesizing a desired behavior from given basic operations, and learning is defined as the dual problem of analyzing a given behavior to determine the unknown basic operations. Algorithms for solving these problems in the context of invertible operations on finite-state environments are developed. In addition to their obvious artificial intelligence applications, the algorithms can efficiently find the shortest way to solve Rubik's cube, test ping-pong protocols, and solve systems of equations over permutation groups.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Involvement in Decision-Making for Daily Care and Cognitive Decline among Older Adults Who Need Care in Japan (2021)

Abstract Effective decision-making regarding daily care for older adults with needs could reduce the risk of dementia by preventing loss of motivation and improving care quality. However, empirical studies are scarce, particularly in non-Western countries with different socio-cultural backgrounds. By using 2-year longitudinal data of older Japanese adults aged 65 years and above who were receiving care at home, as well as of their family caregivers, we examined the association of involvement in decision-making with the onset of cognitive decline among older Japanese adults requiring care. The analysis included 219 cases of individuals with normal cognition and no missing variables at baseline and responded to the follow-up survey. An MMSE score of 23 or lower at follow-up was defined as the onset of cognitive decline. The level of involvement in decision-making was assessed by one item and dichotomized (not involved/involved). The covariates were age, gender, education, MMSE score, eligibility level for long-term care, and others at baseline. At baseline, 67.1% were 75 years or older, 58.9% were female, and 91.8% responded being “involved” in the decision-making. The incidence of cognitive decline at follow-up was 30.6%. The multivariable logistic regression analysis showed that involvement in decision-making (OR=0.298 [95% CI: 0.10-0.88], p=0.029) was negatively and significantly associated with the onset of cognitive decline. Our findings show the importance of involvement in the decision-making for daily care to reduce the risk of subsequent cognitive decline in older adults requiring care, even in a culture of familism.
Accelerated aging test of Solid-State DC Circuit Breaker based on 2.5 kV Reverse Blocking IGCT (2020)

This paper presents the accelerated ageing test results of solid-state circuit breaker based on the 2.5 kV Reverse Blocking IGCT (RB-IGCT). Solid-State Circuit Breakers (SSCB) are protection and safety devices and must have high reliability, especially when a system fault or overload happens. Because circuit breakers operate very differently from the typical power converter and undergo different sets of stresses (continuous on-state gate bias, surge currents and short-circuit withstanding, etc.), a specific reliability and accelerated aging study is necessary. This paper presents the results of accelerated ageing tests, by performing 10,000 short-circuit current interruptions at 1 kV, 4.7 kA, on an RB-IGCT based breaker module and presents the ageing characteristics of the RB-IGCT and the parallel metal oxide varistor (MOV) over the course of testing. The experimental results show about 5-6% increase in on-state forward voltage of the RB-IGCT and a similar percentage increase in the MOV clamping voltage.
Photochromism and Its Application to a High-density Optical Memory (1998)

Abstract In order to solve problems of photochromic memory, a super-low power readout method and a crosstalk reduction method for multi-wavelength recording were proposed. In the demonstration of 2-wavelength recording using photochromic diarylethenes, the crosstalk between multiplexed channels, which is caused from broad absorption bands of compounds, was effectively reduced by the method. A new high density optical memory, a super-resolution disk with a photochromic mask layer, was also introduced. The super-resolution method has enabled us to increase the recording density of conventional optical disks.
K97-0239A and B, new inhibitors of macrophage foam cell formation, produced by <i>Streptomyces</i> sp. K97-0239 (2002)

Streptomyces sp. K97-0239, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. Two compounds, K97-0239A and B, were isolated from the culture broth of the producing strain, and their structures were elucidated by spectroscopic analyses including various NMR experiments. They were cyclic lipopeptides comprising 2, 3-diaminopropionic acid, 4-(aminomethyl)-2, 2-dimethyl-5-oxo-1-imidazolidineacetic acid and phenylalanine/leucine as ring units, and 3-(13-hydroxytetradeca-2, 4-dienoylamino)-acrylic acid as lipophilic side chains. They caused a dose-dependent reduction in the number and size of cytosolic lipid droplets in macrophages at least up to 15μM without any cytotoxic effect on macrophages. [14C] Cholesteryl ester synthesis from [14C] oleic acid by macrophages was inhibited by K97-0239s with IC50 values of 1.5-1.7μM.