gebhart/patrepeval huggingface dataset:
Abstract 181: MIR-18b decreases self-renewal of glioblastoma cancer stem-like cells through targeting NOTCH2, NEDD9, and MEKK1 (2012)

Abstract Glioblastoma (GBM) is the most common malignant brain tumor in human with extremely poor prognosis and new treatment for this deadly disease is desperately needed. Cancer Stem-like cells (CSCs) have been prospectively isolated from GBM and shown required for tumor propagation. We and others have demonstrated recently that differentiation of GBM neurospheres decreases GBM cell propagation both in vitro and in vivo (Zhu et al, Cancer Research, 71:6061-72, 2011). In the current study, we found that miR-18b was up-regulated upon differentiation of GBM neurosphere. When we introduced miR-18b into GBM neurospheres by lentivirus, we found that miR-18b decreases clonogenesis and growth of three different GBM neurosphere lines, indicating that GBM CSC population was reduced by miR-18b. Mechanistically, we found that miR-18b down-regulates luciferase activity of 3′-UTR reporters of NOTCH2, NEDD9, and MEKK1. Furthermore, protein expression of NOTCH2, NEDD9, and MEKK1 are also decreased by miR-18b, suggesting that NOTCH2, NEDD9 and MEKK1 are the direct targets of miR-18b in GBM CSCs. In addition, we have demonstrated previously that NOTCH regulates GBM CSC propagation through pAKT (Fan et al, Stem Cells, 28:5-16, 2010). Here, we found that pAKT and pERK1/2 were also down-regulated in miR-10b infected GBM neurosphere lines, indicating that miR-18b reduces GBM CSC propagation through NOTCH2/pAKT pathways. Taken together, we have demonstrated that miR-18b functions as a tumor suppressor and decreases GBM CSC propagation through targeting NOTCH2, NEDD9, and MEKK1, indicating that miR-18b can be a potential therapeutic molecule to target GBM CSCs and improve GBM treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 181. doi:1538-7445.AM2012-181
Controlled Human Malaria Infection of Healthy Adults With Lifelong Malaria Exposure to Assess Safety, Immunogenicity, and Efficacy of the Asexual Blood Stage Malaria Vaccine Candidate GMZ2 (2018)

Pan-African Clinical Trials: PACTR201503001038304.
HLA-C Antigen Mismatch Is Associated with Worse Outcome in Unrelated Donor Peripheral Blood Stem Cell Transplantation (2010)

The association between HLA matching and outcome in unrelated-donor peripheral blood stem cell (PBSC) transplantation has not yet been established. In the present study, a total of 1933 unrelated donor-recipient pairs who underwent PBSC transplantation between 1999 and 2006 for acute myelogenous leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or chronic myelogenous leukemia and received high-resolution HLA typing for HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 were included in the analysis. Outcomes were compared between HLA-matched and HLA-mismatched pairs, adjusting for patient and transplant characteristics. Matching for HLA-A, -B, -C, and -DRB1 alleles (8/8 match) was associated with better survival at 1 year compared with 7/8 HLA-matched pairs (56% vs 47%). Using 8/8 HLA-matched patients as the baseline (n = 1243), HLA-C antigen mismatches (n = 189) were statistically significantly associated with lower leukemia-free survival (relative risk [RR], 1.36; 95% confidence interval [CI], 1.13-1.64; P = .0010), and increased risk for mortality (RR, 1.41; 95% CI, 1.16-1.70; P = .0005), treatment-related mortality (RR, 1.61; 95% CI, 1.25-2.08; P = .0002), and grade III-IV graft-versus-host disease (RR, 1.98; 95% CI, 1.50-2.62; P < .0001). HLA-B antigen or allele mismatching was associated with an increased risk for acute GVHD grade III-IV. No statistically significant differences in outcome were observed for HLA-C allele (n = 61), HLA-A antigen/allele (n = 136), HLA-DRB1 allele (n = 39), or HLA-DQ antigen/allele (n = 114) mismatches compared with 8/8 HLA-matched pairs. HLA mismatch was not associated with relapse or chronic GVHD. HLA-C antigen-mismatched unrelated PBSC donors were associated with worse outcomes compared with 8/8 HLA-matched donors. The study's limited power due to small sample size precludes conclusions about other mismatches.
mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia (2020)

Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, the role of the metabotropic glutamatergic receptors type 5 (mGluR5) in this disease remains unclear. In this study, we investigated their significance (using [<sup>11</sup> C]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. In the patient group, lower mGluR5 binding potential (BP<sub>ND</sub> ) values in the left temporal cortex and caudate were associated with higher general symptom levels (negative and depressive symptoms), lower levels of global functioning and worse cognitive performance. At the same time, in both groups, mGluR5 BP<sub>ND</sub> were significantly lower in smokers (F<sub>[27,1]</sub> = 15.500; p = .001), but without significant differences between the groups. Our findings provide support for the concept that the impaired function of mGluR5 underlies the symptoms of schizophrenia. They further supply a new perspective on the complex relationship between tobacco addiction and schizophrenia by identifying glutamatergic neurotransmission-in particularly mGluR5-as a possible connection to a shared vulnerability.
DPS - dynamic parallel schedules (2003)

Dynamic Parallel Schedules (DPS) is a high-level framework for developing parallel applications on distributed memory computers (e.g. clusters of PCs). Its model relies on compositional customizable split-compute-merge graphs of operations (directed acyclic flow graphs). The graphs and the mapping of operations to processing nodes are specified dynamically at runtime. DPS applications are pipelined and multithreaded by construction, ensuring a maximal overlap of computations and communications. DPS applications can call parallel services exposed by other DPS applications, enabling the creation of reusable parallel components. The DPS framework relies on a C++ class library. Thanks to its dynamic nature, DPS offers new perspectives for the creation and deployment of parallel applications running on server clusters.
Adsorption of Chlorinated Ethylenes at 1-Octadecanethiol-Modified Silver Surfaces (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption of Chlorinated Ethylenes at 1-Octadecanethiol-Modified Silver SurfacesKen. Mullen and Keith. CarronCite this: Anal. Chem. 1994, 66, 4, 478–483Publication Date (Print):February 15, 1994Publication History Published online1 May 2002Published inissue 15 February 1994https://pubs.acs.org/doi/10.1021/ac00076a010https://doi.org/10.1021/ac00076a010research-articleACS PublicationsRequest reuse permissionsArticle Views339Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxigenação de águas em colunas de borbulhamento a operar em escoamento co-corrente descendente (2009)

Apresenta-se um estudo teorico e experimental sobre transferencia de massa num escoamento co-corrente descendente de oxigenio-agua em colunas de borbulhamento verticais. As experiencias foram efectuadas num tubo de 32 mm de diâmetro interno e 5.37 m de altura. A velocidade superficial do liquido variou entre 0.3 e 0.8 m/s e a razao de caudais volumetricos gas/liquido entre 0.015 e 0.30. Desenvolve-se um modelo teorico de transferencia de massa para este tipo de escoamento. Obteve-se para a razao entre o coeficiente de transferencia de massa e o raio inicial das bolhas, kL/r0=0.12 s.
Figure S2 from JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma (2023)

&lt;p&gt;EGFR and c-Myc proteins are overexpressed to similar levels in F0 and corresponding F1 tumors.&lt;/p&gt;
ChemInform Abstract: Catalytic Enantioselective Amination of Enolsilanes Using C2‐Symmetric Copper(II) Complexes as Chiral Lewis Acids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Comprehensive Experimental Emulation for OTFS Waveform RF-Impairments (2022)

The orthogonal time-frequency space (OTFS) waveform exceeds the challenges that face orthogonal frequency division multiplexing (OFDM) in a high-mobility environment with high time-frequency dispersive channels. Since radio frequency (RF) impairments have a direct impact on waveform behavior, this paper investigates the experimental implementation of RF-impairments that affect OTFS waveform performance and compares them to the OFDM waveform as a benchmark. Firstly, the doubly-dispersive channel effect is analyzed, and then an experimental framework is established for investigating the impact of RF-impairments, including non-linearity, carrier frequency offset (CFO), I/Q imbalances, DC-offset, and phase noise are considered. The experiments were conducted in a real indoor wireless environment using software-defined radio (SDR) at carrier frequencies of 2.4 GHz and 5 GHz based on the Keysight EXG X-Series devices. The comparison of the performances of OFDM and OTFS in the presence of RF-impairments reveals that OTFS significantly outperforms OFDM.
Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer (2009)

The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed for CA IX expression by three different evaluations: positive/negative, proportion of positivity and staining intensity. The results of immunohistochemical analysis were confirmed by demonstrating CA IX protein in western blotting analysis. Forty-four percent of the operative samples were CA IX positive, of these 34% had weak and 66% moderate/strong staining intensity. In univariate survival analysis, intensity of CA IX expression was a predictor of DFS (P=0.003) and DSS (P=0.034), both being markedly longer in tumours with negative or weakly positive staining. In multivariate Cox model, number of metastatic lymph nodes and CA IX intensity were the only independent predictors of DFS. Carbonic anhydrase isozyme IX intensity was the only independent predictor of DSS, with HR=9.2 for dying of disease with moderate-intense CA IX expression as compared with CA IX-negative/weak cases. Negative/weak CA IX staining intensity is an independent predictor of longer DFS and DSS in rectal cancer.
Supplementary Table S5 from Gain-of-Function <i>RHOA</i> Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer (2023)

&lt;p&gt;Antibodies&lt;/p&gt;
Diterpenoid Acids from Grindelia nana (2000)

Two new norditerpenoid acids of the labdane-type (norgrindelic acids), 4,5-dehydro-6-oxo-18-norgrindelic acid (1) and 4beta-hydroxy-6-oxo-19-norgrindelic acid (2), as well as a new grindelic acid derivative, 18-hydroxy-6-oxogrindelic acid (3), were isolated from the aerial parts of Grindelia nana. In addition, the known compounds, 6-oxogrindelic acid, grindelic acid, methyl grindeloate, 7alpha,8alpha-epoxygrindelic acid, and 4alpha-carboxygrindelic acid were also isolated. The structures of the new compounds were characterized on the basis of spectroscopic analysis.
α-Thrombin Stimulates Urokinase Production and DNA Synthesis in Cultured Human Cerebral Microvascular Endothelial Cells (1995)

alpha-Thrombin regulation of endothelial cell (EC) fibrinolysis has been documented by using endothelia derived from a number of anatomic locations but not with those derived from the human cerebral vasculature. In the present study, the fibrinolytic properties of human cerebral microvascular ECs and their regulation by alpha-thrombin are delineated and contrasted with those of human umbilical vein and foreskin microvascular ECs. In cerebral ECs, alpha-thrombin elicited a unique dose-dependent increase in urokinase production and DNA synthesis. Maximal stimulation, observed with 10 nmol/L alpha-thrombin, resulted in a 30- to 50-fold increase in urokinase production and a concomitant fourfold increase in DNA synthesis; the increase in urokinase was reflected in higher steady-state levels of urokinase mRNA. The major urokinase product secreted is the single-chain form of the enzyme. No effect was observed with the addition of other proteases or catalytically inactive variants of alpha-thrombin. A thrombin receptor agonist peptide upregulated urokinase production but had no effect on DNA synthesis, suggesting that fibrinolysis is mediated by the thrombin receptor but that proliferation is regulated by a different pathway. These findings suggest the possibility that the cerebral microvasculature may be a specialized region of the vascular system in which urokinase-type plasminogen activator, not tissue-type plasminogen activator, is the key catalyst of fibrin lysis when the brain responds to thrombotic events and that alpha-thrombin may regulate repair of the cerebral microvascular system.
Facile preparation of porous alumina through-hole masks for sputtering by two-layer anodization (2016)

Highly ordered porous alumina through-hole masks were fabricated on a substrate by combining two-layer anodization with subsequent through-holing by selective etching. This process allowed the fabrication of porous alumina masks without an increase in pore size during the etching performed for through-holing. Additionally, the process contributed to improved operability in the setting of the masks on substrates because the second anodizing layer acts as a supporting layer for the handling of the mask. The fabrication of ordered Au nanodot arrays was demonstrated as an example application of the through-hole masks obtained by the present process.
In Vivo Wear of a Squeaky Alumina-on-Alumina Hip Prosthesis (2011)

Laurent, Michel P. PhD; Pourzal, Robin MS; Fischer, Alfons PhD; Bertin, Kim C. MD; Jacobs, Joshua J. MD; Wimmer, Markus A. PhD Author Information
Correction: Post-functionalized iridium–Zr-MOF as a promising recyclable catalyst for the hydrogenation of aromatics (2015)

Correction for ‘Post-functionalized iridium–Zr-MOF as a promising recyclable catalyst for the hydrogenation of aromatics’ by Antonia M. Rasero-Almansa <italic>et al.</italic>, <italic>Green Chem.</italic>, 2014, <bold>16</bold>, 3522–3527.
Ubiquitin-Proteasome System Stress Sensitizes Ovarian Cancer to Proteasome Inhibitor–Induced Apoptosis (2006)

The ubiquitin-proteasome system (UPS) mediates targeted protein degradation. Notably, the UPS determines levels of key checkpoint proteins controlling apoptosis and proliferation by controlling protein half-life. Herein, we show that ovarian carcinoma manifests an overstressed UPS by comparison with normal tissues by accumulation of ubiquitinated proteins despite elevated proteasome levels. Elevated levels of total ubiquitinated proteins and 19S and 20S proteasome subunits are evident in both low-grade and high-grade ovarian carcinoma tissues relative to benign ovarian tumors and in ovarian carcinoma cell lines relative to immortalized surface epithelium. We find that ovarian carcinoma cell lines exhibit greater sensitivity to apoptosis in response to proteasome inhibitors than immortalized ovarian surface epithelial cells. This sensitivity correlates with increased cellular proliferation rate and UPS stress rather than absolute proteasome levels. Proteasomal inhibition in vitro induces cell cycle arrest and the accumulation of p21 and p27 and triggers apoptosis via activation of caspase-3. Furthermore, treatment with the licensed proteasome inhibitor PS-341 slows the growth of ES-2 ovarian carcinoma xenograft in immunodeficient mice. In sum, elevated proliferation and metabolic rate resulting from malignant transformation of the epithelium stresses the UPS and renders ovarian carcinoma more sensitive to apoptosis in response to proteasomal inhibition.
Variant phasing and haplotypic expression from long-read sequencing in maize (2020)

Haplotype phasing maize genetic variants is important for genome interpretation, population genetic analysis and functional analysis of allelic activity. We performed an isoform-level phasing study using two maize inbred lines and their reciprocal crosses, based on single-molecule, full-length cDNA sequencing. To phase and analyze transcripts between hybrids and parents, we developed IsoPhase. Using this tool, we validated the majority of SNPs called against matching short-read data from embryo, endosperm and root tissues, and identified allele-specific, gene-level and isoform-level differential expression between the inbred parental lines and hybrid offspring. After phasing 6907 genes in the reciprocal hybrids, we annotated the SNPs and identified large-effect genes. In addition, we identified parent-of-origin isoforms, distinct novel isoforms in maize parent and hybrid lines, and imprinted genes from different tissues. Finally, we characterized variation in cis- and trans-regulatory effects. Our study provides measures of haplotypic expression that could increase accuracy in studies of allelic expression.
Nanoparticulated Dense and Stress‐Free Ceramic Thick Film for Material Integration (2013)

A dense, thick, and organic-binder-free ceramic film consisting of stress-free nanoparticles could be obtained at room temperature by making use of the unstable and high-surface energy amorphous phase on the surface of particles. Photolithography and wet etching can be adapted to the thick ceramic green-state film. A multilayered structure consisting of various ceramics with different sintering temperatures and Cu wiring can form on a Cu foil below 1000 °C.
Synthesis and SAR of Highly Potent and Selective Dopamine D3‐Receptor Antagonists: Variations on the 1H‐Pyrimidin‐2‐one Theme. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of a MEMS Based Integrated Hot-Film Flow Sensor (2010)

Previous research at BAE Systems has developed a MEMS based hot-film sensor that can be flush mounted into a surface with sub-surface connections. The work described in this paper covers the development of a device that integrates this MEMS sensor, with an integrated, miniaturized constant temperature anemometer circuit, and a miniaturized laminar/turbulent flow detection circuit. Attention has also been paid to addressing how this might be incorporated into an aircraft structure and systems. The ultimate aim is a flightworthy sensor that includes all the necessary components into a single package of the order of a few cm 3 , which only requires three wires - power, earth and data, and which can easily be integrated into an aircraft structure.
An architecture for real time television audience measurement (2011)

Currently, audience measurement reports of television programs are only available after a significant period of time, for example as a daily report. This paper proposes an architecture for real time measurement of television audience. Real time measurement can give channel owners and advertisers important information that can positively impact their business. We show that television viewership can be captured by set top box devices which detect the channel logo and transmit the viewership data to a server over internet. The server processes the viewership data and displays it in real time on a web-based dashboard. In addition, it has facility to display charts of hourly and location-wise viewership trends and online TRP (Television Rating Points) reports. The server infrastructure consists of in-memory database, reporting and charting libraries and J2EE based application server.
Reservoir Fluid Analysis As A Proxy For Connectivity In Deepwater Reservoirs (2010)

In deepwater prospects, reservoir connectivity is often the largest uncertainty for defining recoverable reserves. As no single measurement provides a complete solution, it is desirable to combine multiple methods to address this risk. Traditional geochemical measurements have been coupled with downhole fluid analysis (DFA) measurements to demonstrate compartmentalization and to provide better screening for connectivity. DFA helps uncover compartments by looking for density inversions (higher density fluids higher in the oil column) and by identifying discontinuities in fluid properties. To identify compartmentalization, it is essential to differentiate between discontinuous fluid profiles versus continuous or smoothly varying profiles, which are typical of connected reservoirs. A variety chemical analytes can be used to explore connectivity including methane, asphaltene, and isotope analysis. In this paper, fluid profiles are examined by a variety of measurements. Different fluid data streams are shown to be sensitive to different attributes enabling several analysis methods to explore sealing barriers. The analysis of asphaltene gradients by DFA is now known to provide an excellent method to interrogate black oil columns. Case studies are shown to provide indications of connectivity; risk factors are also discussed along with the integration with pressure measurements.