gebhart/patrepeval huggingface dataset:
A phase 1, open-label, multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in subjects with resected solid tumors and in combination with pembrolizumab in subjects with unresectable solid tumors (Keynote-603). (2019)

93 Background: T-cell targeting of mutation-derived epitopes (neoantigens) has been demonstrated to drive anti-tumor responses. Immunizing patients against such neoantigens in combination with a checkpoint inhibitor (CPI) may elicit greater anti-tumor responses than CPI alone. Mutations are rarely shared between patients, thus requiring a personalized approach to vaccine design. Methods: This is an interim report of a phase I dose escalation study of mRNA-4157 given as monotherapy in patients with resected solid tumors and in combination with pembrolizumab in patients with unresectable solid tumors. mRNA-4157 is a lipid encapsulated personalized vaccine encoding multiple neoantigens selected using a proprietary algorithm designed to induce neoantigen specific T cells and associated anti-tumor responses. Patients received up to 9 cycles (Q3W) of mRNA-4157 by IM injection (0.04 – 1 mg). In combination arm, pembrolizumab (200 mg) was administered for two cycles prior to combination with mRNA-4157 for up to 9 cycles and may continue on pembrolizumab monotherapy for up to 2 years. Results: As of 10-May-2019, 33 patients received mRNA-4157 alone or in combination. No DLTs or related SAEs or AEs ≥ grade 3 were reported. Of the 13 patients treated with monotherapy (3 melanoma, 8 NSCLC, 2 MSI-high CRC), 11 patients remain disease free on study, median follow-up of 10 months. Of the 20 patients treated in combination (1 TMB-high metastatic cutaneous squamous cell, 4 bladder, 2 HNSCC, 1 melanoma, 7 NSCLC, 2 SCLC, 3 MSI-high (CRC, prostate, endometrial), 13 had received prior CPI, 5 PRs (2 in patients previously treated with PD-1/L1 inhibitors), 6 SD, and 8 PD were reported. Neoantigen specific CD8+ T-cell responses have been detected. Conclusions: mRNA-4157 is safe and well tolerated at all dose levels tested. Clinical responses have been observed in combination with pembrolizumab and neoantigen-specific T cells have been induced, supporting the advancement of mRNA-4157 to phase 2. Clinical trial information: NCT 03739931.
Abstract 245: Cardiac Stem Cells and Myocyte Regeneration in Diabetic Cardiomyopathy (2013)

The mammalian heart contains a pool of resident c-kit-positive cardiac stem cells (CSCs), raising questions concerning their role in the etiology of the diabetic myopathy. The objective of the current study was to determine whether the negative effects of diabetes on the adult heart are dictated by defects in CSC growth and lineage commitment. Type I insulin-dependent diabetes mellitus was induced in mice by streptozotocin administration. The kinetics of CSCs and cardiomyocytes was measured 3, 7, 10, 20, and 30 days after the onset of diabetes, by implementing a hierarchically structured cell system, which allows the quantitative analysis of the rate of cell turnover. The multiple variables required to apply this mathematical model were measured by confocal microscopy. They included first the number of CSCs, LCCs (lineage committed cells: myocyte progenitors-precursors), transit amplifying myocytes, and post-mitotic myocytes in the left ventricular (LV) myocardium. Additionally, the fraction of cycling CSCs and the length of their cell cycle were measured, together with the number of cardiomyocytes dying by apoptosis and necrosis. The specificity of labeling was documented by spectral analysis. The diabetic heart was characterized by a severe time-dependent loss in LV post-mitotic myocytes, dictated primarily by a defect in cell renewal. Under control conditions, 20% of myocytes were replaced per month in the adult mouse heart through activation, cell cycle reentry, and differentiation of CSCs. This value decreased sharply to 6%, 1.4%, 0.5%, 0.07%, and 0.05% at 3, 7, 10, 20 and 30 days after the administration of streptozotocin. The myocardium showed a progressive increase in old cardiomyocytes expressing the senescence-associated protein p16INK4a and p53. Importantly, the severe impairment in myocyte regeneration was coupled with an increase in LV end-diastolic pressure, and a decrease in LV systolic pressure, LV developed pressure, positive and negative dP/dt. Thus, our data indicate that the diabetic myopathy has to be viewed as a stem cell disease in which the decrease in the number of myocytes is a secondary event, resulting from defects in replication and lineage specification of cardiac stem cells.
Observation of a new baryon state in the $$ {\Lambda}_{\mathrm{b}}^0{\pi}^{+}{\pi}^{-} $$ mass spectrum (2020)

A bstract A new baryon state is observed in the $$ {\Lambda}_{\mathrm{b}}^0{\pi}^{+}{\pi}^{-} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>Λ</mml:mi> <mml:mi>b</mml:mi> <mml:mn>0</mml:mn> </mml:msubsup> <mml:msup> <mml:mi>π</mml:mi> <mml:mo>+</mml:mo> </mml:msup> <mml:msup> <mml:mi>π</mml:mi> <mml:mo>−</mml:mo> </mml:msup> </mml:math> mass spectrum with high significance using a data sample of pp collisions, collected with the LHCb detector at centre-of-mass energies $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 7 , 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb − 1 . The mass and natural width of the new state are measured to be $$ {\displaystyle \begin{array}{l}m=6072.3\pm 2.9\pm 0.6\pm 0.2\ \mathrm{MeV},\\ {}\Gamma =72\pm 11\pm 2\ \mathrm{MeV},\end{array}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mtable> <mml:mtr> <mml:mtd> <mml:mi>m</mml:mi> <mml:mo>=</mml:mo> <mml:mn>6072.3</mml:mn> <mml:mo>±</mml:mo> <mml:mn>2.9</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.6</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.2</mml:mn> <mml:mspace/> <mml:mi>MeV</mml:mi> <mml:mo>,</mml:mo> </mml:mtd> </mml:mtr> <mml:mtr> <mml:mtd> <mml:mi>Γ</mml:mi> <mml:mo>=</mml:mo> <mml:mn>72</mml:mn> <mml:mo>±</mml:mo> <mml:mn>11</mml:mn> <mml:mo>±</mml:mo> <mml:mn>2</mml:mn> <mml:mspace/> <mml:mi>MeV</mml:mi> <mml:mo>,</mml:mo> </mml:mtd> </mml:mtr> </mml:mtable> </mml:math> where the first uncertainty is statistical and the second systematic. The third uncertainty for the mass is due to imprecise knowledge of the $$ {\Lambda}_{\mathrm{b}}^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>Λ</mml:mi> <mml:mi>b</mml:mi> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> baryon mass. The new state is consistent with the first radial excitation of the $$ {\Lambda}_{\mathrm{b}}^0 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>Λ</mml:mi> <mml:mi>b</mml:mi> <mml:mn>0</mml:mn> </mml:msubsup> </mml:math> baryon, the Λ b (2S) 0 resonance. Updated measurements of the masses and the upper limits on the natural widths of the previously observed Λ b (5912) 0 and Λ b (5920) 0 states are also reported.
Polymer Thin Films on Patterned Si Surfaces (1998)

The propagation of roughness from a patterned silicon surface by polymer thin films was measured as a function of film thickness, time, and surface interaction using atomic force microscopy and synchrotron X-ray reflection. In the presence of an interacting surface, the decay length of the surface modulation was much longer than that observed in simple liquids. By measuring the time dependence of the surface corrugation amplitude, we were able to extract a surface diffusion coefficient by applying a modified version of the Mullins theory for surface diffusion in crystalline solids. The measured diffusion coefficients were an order of magnitude smaller than in the bulk, and scaled as 1/M3/2, in agreement with previous SIMS results. The results are interpreted in terms of surface interactions confining polymer chains over distances larger than the radii of gyration.
Gait Analysis of Patients with Hip Ankylosis: Post Operative Change (2005)

The gait of five patients with unilateral hip ankylosis was analyzed both before and after operation (total hip arthroplasty) in terms of distribution of stance phase rate (stance phase/gait cycle), step length, stride width, and foot angle. After operation, stride width and foot angle significantly improved. Step length was shortened with the decrease of gait speed. There was no significant change in the stance phase rate. Gait functions that do not depend on the knee, pelvis, and the ankle were achieved after total hip arthroplasty.
Recent Advances in Waste Plastic Transformation into Valuable Platinum‐Group Metal‐Free Electrocatalysts for Oxygen Reduction Reaction (2021)

Plastic waste causes severe environmental hazards, owing to inadequate disposal and limited recycling. Under the framework of circular economy, there are urgent demands to valorize plastic waste more safely and sustainably. Therefore, much scientific interest has been witnessed recently in plastic waste-derived electrocatalysts for the oxygen reduction reaction (ORR), where the plastic waste acts as a cost-effective and easily available precursor for the carbon backbone. The ORR is not only a key efficiency indicator for fuel cells and metal-air batteries but also a major obstacle for their commercial realization. The applicability of the aforementioned electrochemical devices is limited, owing to sluggish ORR activity and expensive platinum-group metal electrocatalysts. However, waste-derived ORR electrocatalysts are emerging as a potential substitute that could be inexpensively fabricated upon the conversion of plastic waste into active materials containing earth-abundant transition metals. In this Minireview, very recent research developments regarding plastic waste-derived ORR electrocatalysts are critically summarized with a prime focus on the followed synthesis routes, physicochemical properties of the derived electrocatalysts, and their ultimate electrochemical performance. Finally, the prospects for the future development of plastic waste-derived electrocatalysts are discussed.
Ozonation:  A Unique Route To Prepare Nickel Oxyhydroxides. Synthesis Optimization and Reaction Mechanism Study (2005)

This paper details the reacting paths involved during the oxidation of αII-Ni(OH)2 and βII-Ni(OH)2 with ozone, which is compared to the oxidation process conducted in aqueous solution. The main advantage of the ozone method lies in the control of the reaction medium steps owing to the feasibility of operating in the presence or absence of alkaline cations. This enables the preparation of the pure βIII-NiOOH phase, well-known to be difficult to obtain in aqueous media without γIII-NiOOH traces. The reaction mechanisms for both oxidation processes were found to be similar, and to yield the same final products, except for αII-Ni(OH)2, where ozonation allowed the preparation of a new oxidized phase that was isolated and characterized by means of complementary techniques such as X-ray diffraction, chemical analysis, HRTEM, TGA, and FT-IR. A mechanism to account for the formation of this phase is proposed.
Poly(ethylene glycol) with Observable Shedding (2010)

Die Spaltung eines Polyethylenglycol(PEG)-Nanopartikel(NP)-Konjugats mit FRET resultiert in einer Fluoreszenz bei 520 nm (siehe Bild). Wurden die Nanopartikel auf Krebszelllinien als Ziel gerichtet, bewirkte die reduzierende Umgebung des Endosoms die Spaltung der Disulfidbindung und das Auflösen der PEG-Schicht.
Aeroelastic simulation of multi-MW wind turbines using a free vortex model coupled to a geometrically exact beam model (2016)

The current paper investigates the aeroelastic modelling of large, flexible multi- MW wind turbine blades. Most current performance prediction tools make use of the Blade Element Momentum (BEM) model, based upon a number of simplifying assumptions that hold only under steady conditions. This is why a lifting line free vortex wake (LLFVW) algorithm is used here to accurately resolve unsteady wind turbine aerodynamics. A coupling to the structural analysis tool BeamDyn, based on geometrically exact beam theory, allows for time-resolved aeroelastic simulations with highly deflected blades including bend-twist, coupling. Predictions of blade loading and deformation for rigid and flexible blades are analysed with reference to different aerodynamic and structural approaches. The emergency shutdown procedure is chosen as an examplary design load case causing large deflections to place emphasis on the influence of structural coupling and demonstrate the necessity of high fidelity structural models.
Chemical Synthesis of Burkholderia Lipid A Modified with Glycosyl Phosphodiester‐Linked 4‐Amino‐4‐deoxy‐β‐L‐arabinose and Its Immunomodulatory Potential (2015)

Modification of the Lipid A phosphates by positively charged appendages is a part of the survival strategy of numerous opportunistic Gram-negative bacteria. The phosphate groups of the cystic fibrosis adapted Burkholderia Lipid A are abundantly esterified by 4-amino-4-deoxy-β-L-arabinose (β-L-Ara4N), which imposes resistance to antibiotic treatment and contributes to bacterial virulence. To establish structural features accounting for the unique pro-inflammatory activity of Burkholderia LPS we have synthesised Lipid A substituted by β-L-Ara4N at the anomeric phosphate and its Ara4N-free counterpart. The double glycosyl phosphodiester was assembled by triazolyl-tris-(pyrrolidinyl)phosphonium-assisted coupling of the β-L-Ara4N H-phosphonate to α-lactol of β(1→6) diglucosamine, pentaacylated with (R)-(3)-acyloxyacyl- and Alloc-protected (R)-(3)-hydroxyacyl residues. The intermediate 1,1'-glycosyl-H-phosphonate diester was oxidised in anhydrous conditions to provide, after total deprotection, β-L-Ara4N-substituted Burkholderia Lipid A. The β-L-Ara4N modification significantly enhanced the pro-inflammatory innate immune signaling of otherwise non-endotoxic Burkholderia Lipid A.
In vitro studies on the activity of amphotericin B and lipid‐based amphotericin B formulations against Aspergillus conidia and hyphae (2002)

The minimum inhibitory concentrations (MICs) of amphotericin B and lipid-based amphotericin B formulations against isolates of Aspergillus spp. were tested using a broth microdilution method. Twelve isolates of Aspergillus fumigatus, eight of Aspergillus flavus, six of Aspergillus niger and seven of Aspergillus terreus were examined. In addition, an assay for hyphae of Aspergillus spp. was performed since the invasive form is manifested by the appearance of hyphal structures. MICs of hyphae against lipid-based amphotericin B formulations were within three dilutions higher than those against conidia for almost all isolates of Aspergillus spp. (P < 0.01). In contrast, the differences in the in vitro efficacies of amphotericin B were the lowest for Aspergillus spp. This study demonstrates the importance of the type of inoculum used to test antifungal susceptibilities of Aspergillus spp. The significance of these results for in vivo outcome needs to be determined.
Association of Dapagliflozin vs Placebo With Individual Kansas City Cardiomyopathy Questionnaire Components in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction (2023)

ClinicalTrials.gov Identifier: NCT03619213.
Demonstrating Adaptive Imaging on Complex Source Scenes made with Special Nuclear Material (2020)

Abstract not provided.
Supplementary Fig S8 from Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing (2023)

&lt;p&gt;Supplementary Fig S8 and legend&lt;/p&gt;
Blind chip- and symbol rate CDMA receivers (2003)

This paper deals with the problem of blind (and semi-blind) estimation of linear DS-CDMA receivers using multiple antennas in asynchronous intersymbol interference (ISI) channels. We introduce simple relations between receivers at the symbol rate and at the chip rate and derive deterministic constraints that can be used to determine these receivers in a blind manner, with small sample sizes. The chip rate receiver is shown to be close to the MMSE receiver. Connections with existing techniques are discussed.
Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy (2021)

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety and hyperactivity. Despite their availability, so far advances in drug development have not yielded new treatments. Therefore, testing novel drugs that can ameliorate FXS' cognitive and behavioral impairments is imperative. ANAVEX2-73 (blarcamesine) is a sigma-1 receptor (S1R) agonist with a strong safety record and preliminary efficacy evidence in patients with Alzheimer's disease and Rett syndrome, other synaptic neurodegenerative and neurodevelopmental disorders. S1R's role in calcium homeostasis and mitochondrial function, cellular functions related to synaptic function, makes blarcamesine a potential drug candidate for FXS. Administration of blarcamesine in 2-month-old FXS and wild type mice for 2 weeks led to normalization in two key neurobehavioral phenotypes: open field test (hyperactivity) and contextual fear conditioning (associative learning). Furthermore, there was improvement in marble-burying (anxiety, perseverative behavior). It also restored levels of BDNF, a converging point of many synaptic regulators, in the hippocampus. Positron emission tomography (PET) and ex vivo autoradiographic studies, using the highly selective S1R PET ligand [<sup>18</sup>F]FTC-146, demonstrated the drug's dose-dependent receptor occupancy. Subsequent analyses also showed a wide but variable brain regional distribution of S1Rs, which was preserved in FXS mice. Altogether, these neurobehavioral, biochemical, and imaging data demonstrates doses that yield measurable receptor occupancy are effective for improving the synaptic and behavioral phenotype in FXS mice. The present findings support the viability of S1R as a therapeutic target in FXS, and the clinical potential of blarcamesine in FXS and other neurodevelopmental disorders.
An exploratory study of input configuration and group process in a negotiation task using a large display (2007)

This paper reports on an exploratory study of the effects of input configuration on group behavior and performance in a collaborative task performed by a collocated group using a large display. Twelve groups completed a mixed-motive negotiation task under two conditions: a single, shared mouse and one mouse per person. Results suggest that the multiple mouse condition allowed for more parallel work, but the quality of discussion was higher in the single mouse condition. Moreover, participants were more likely to act in their own best interest in the multiple mouse condition.
Erratum: Search for the associated production of the Higgs boson with a top-quark pair (2014)

The x-axis of figure 2, lower left panel ("Lepton + 6 jets + 2 b-tags") should be replaced with "3 rd highest CSV output".
Accessible, Open-source Hardware and Process Designs for 3D Bioprinting and Culturing Channels Lined with iPSC-derived Vascular Endothelial Cells (2021)

Abstract Indirect bioprinting for cell culture requires the use of several technologies and techniques which currently prevent many researchers not specialized in electrical engineering or materials science from accessing these new tools. In this paper, a printer and all necessary associated hardware was developed and tested for the purpose of seeding human induced Pluripotent Stem Cell (iPSC)-derived endothelial cells (iECs) onto all surfaces of a fibringelatin channel. Immature iECs were seeded onto all channel surfaces and completed differentiation along channel walls. All required tools and methods, including engineering drawing, printable files, code, and hand-tool templates, have been provided with sufficient clarity to enable full, open-source replication of all technique employed.
Rapid Ion Exchange during Redox Switching of Poly(3-methylthiophene) Studied by X-ray Photoelectron Spectroscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid Ion Exchange during Redox Switching of Poly(3-methylthiophene) Studied by X-ray Photoelectron SpectroscopyCynthia M. G. Bach and John R. ReynoldsCite this: J. Phys. Chem. 1994, 98, 51, 13636–13642Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/j100102a033https://doi.org/10.1021/j100102a033research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Defining genes that govern longevity inCaenorhabditis elegans (1996)

We previously identified five regions on the chromosomal map of Caenorhabditis elegans, containing genes that help specify life span in this species, by comparing the genotypes of young and long-lived progeny from a cross between strains Bristol-N2 and Bergerac-BO [Ebert et al. (1993): Genetics 135:1003-1010]. Analyses of additional crosses, and of putative polymorphisms for the implicated genes, are necessary to clarify the roles of naturally occurring polymorphic alleles in determining longevity. We therefore carried out a second multigenerational cross, between strains Bristol-N2 and DH424 (both nonmutators at 20 degrees C), to create a different heterogeneous recombinant-inbred population. We again found strong evidence implicating multiple genes, which differ between the parental strains, in the determination of life span. Increased variance of survival, for F2 and homozygous F25 worms relative to F1 hybrids, is consistent with such alleles assorting randomly in the cross progeny. Moreover, chromosome mapping data corroborate the polygenic nature of this quantitative trait. Genotypes of young and very long-lived adult worms from a synchronous F15 population were determined by polymerase chain reaction, to identify the parental strain of origin for each of 10 polymorphic loci. Two regions, on chromosomes II and IV, each contain at least one gene with allelic differences in associated longevity. A recombinant-inbred Bergerac-BO x Bristol-N2 population, derived from the earlier cross between those strains, was exposed to an acute toxic level of hydrogen peroxide. Genotyping of H2O2-resistant worms implicated at least one of the five chromosomal regions previously identified in the same cross progeny as harboring a longevity-determining gene. Superoxide dismutase and catalase levels, determined for the three parental strains as they aged, confirm the existence of polymorphisms in the corresponding genes (or their regulatory mechanisms) inferred from the chromosome-II mapping data, and are consistent with the hypothesis that increased longevity is conferred by high levels of these enzymes late in life.