gebhart/patrepeval huggingface dataset:
Abstract 1502: Pre-conditioning modifies the tumor microenvironment to enhance solid tumor CAR T cell efficacy and endogenous immunity (2021)

Abstract Chimeric antigen receptor (CAR) T cell therapy has led to impressive clinical responses in patients with hematological malignancies; however, its utility in patients with solid tumors has been limited. While CAR T cells for the treatment of advanced prostate cancer are being clinically evaluated and are anticipated to show bioactivity, their safety and the impact of the immunosuppressive tumor microenvironment (TME) have not been faithfully explored preclinically. Using a novel human prostate stem cell antigen knock-in (hPSCA-KI) immunocompetent mouse model and syngeneic murine PSCA CAR T cells, we performed analyses of normal and tumor tissues by flow cytometry, immunohistochemistry, and/or RNA sequencing. We further assessed the beneficial impact of cyclophosphamide (Cy) pre-conditioning on modifications to the immunosuppressive TME and impact on PSCA-CAR T cell safety and efficacy. We observed an in vivo requirement of Cy pre-conditioning in uncovering the efficacy of PSCA-CAR T cells in prostate and pancreas cancer models, with no observed toxicities in normal tissues with endogenous PSCA expression. This combination also dampened the immunosuppressive TME, generated pro-inflammatory myeloid and T cell signatures in tumors, and enhanced the recruitment of antigen-presenting cells, and endogenous as well as adoptively-transferred CAR T cells, resulting in long-term anti-tumor immunity. Citation Format: John P. Murad, Dileshni Tilakawardane, Anthony K. Park, Kelly T. Kennewick, Lupita S. Lopez, Hee J. Lee, Brenna J. Gittins, Wen-Chung Chang, Chau P. Tran, Catalina Martinez, Anna M. Wu, Robert E. Reiter, Tanya B. Dorff, Stephen J. Forman, Saul J. Priceman. Pre-conditioning modifies the tumor microenvironment to enhance solid tumor CAR T cell efficacy and endogenous immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1502.
DC-Side Impedance Interaction Analysis in an MMC-Based Back-to-Back VSC-HVDC System (2021)

In this paper, harmonic stability of a back-to-back modular multilevel converter based voltage source converter high voltage direct current system is analyzed. These systems are prone to ac- and dc-side resonances and interactions between the converter and its interconnected systems. The stability of the system can be predicted by the impedance based stability criterion, which requires the modeled or measured converter impedance. The analysis in this paper focuses on interoperability when the converters employ different control schemes in order to utilize the inherent damping properties of the sum capacitor voltage balancing control loops.
Evolving trends in the treatment of low‐risk myelodysplastic syndromes: immunomodulation and beyond—9th European Hematology Association Congress Geneva, Switzerland, 10–13 June 2004 (2007)

The 9th European Hematology Association Congress, held in Geneva, Switzerland, from 10 through 13 June 2004, offered a number of educational programmes that focused on myelodysplastic syndromes (MDS). This report will summarize the material presented at the educational symposium entitled 'Evolving Trends in the Treatment of Low-Risk MDS: Immunomodulation and Beyond'. The overview of the presentations includes a comparative review of the classification systems for MDS; a discussion of treatment strategies and management issues for patients in lower risk disease categories; a description of a novel class of immunomodulators, the IMiDs((R)), and a presentation of updated data from clinical trials of the IMiD compound, lenalidomide, in the treatment of MDS.
PRANC: Pseudo RAndom Networks for Compacting deep models (2022)

We demonstrate that a deep model can be reparametrized as a linear combination of several randomly initialized and frozen deep models in the weight space. During training, we seek local minima that reside within the subspace spanned by these random models (i.e., `basis' networks). Our framework, PRANC, enables significant compaction of a deep model. The model can be reconstructed using a single scalar `seed,' employed to generate the pseudo-random `basis' networks, together with the learned linear mixture coefficients. In practical applications, PRANC addresses the challenge of efficiently storing and communicating deep models, a common bottleneck in several scenarios, including multi-agent learning, continual learners, federated systems, and edge devices, among others. In this study, we employ PRANC to condense image classification models and compress images by compacting their associated implicit neural networks. PRANC outperforms baselines with a large margin on image classification when compressing a deep model almost $100$ times. Moreover, we show that PRANC enables memory-efficient inference by generating layer-wise weights on the fly. The source code of PRANC is here: \url{https://github.com/UCDvision/PRANC}
Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans (2019)

Aging, a universal and unique process, occurs both intrinsically (chronological) and extrinsically (photoaging). Ultraviolet-A (UV-A)-mediated stress is a growing health hazard to mankind as it is the major cause of photoaging, which could lead to much damage of skin cells and tissues ranging from tan, burn, or even cancer. The present study focuses on the role of antioxidants and other natural compounds which have been widely used in oral/topical applications to combat and delay the effects of photoaging using model nematode Caenorhabditis elegans. Compounds like green tea extract, naringenin, and naringin, which are known for their antioxidant properties, were able to extend life span and healthspan of the nematode in normal as well as under UV-A-mediated stress conditions. Regulation of both the stress-responsive genes (skn-1 and sir-2.1) and the aging-regulating genes (daf-2 and age-1) was attributable for these conditions. Interestingly, it was observed that these compounds when combined in equal ratios by weight worked synergistically to combat the aging process. Pronounced synergistic effects were observed during UV-A-mediated stress conditions, suggesting that these could be used as potential antiphotoaging compounds which will be of greater significance for health-based research.
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference (2016)

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10<sup>-12</sup>). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.
Multi-Player Pursuer Coordination for Nonlinear Reach-Avoid Games in Arbitrary Dimensions via Coverage Control (2020)

The concept of reach-avoid (RA) games via coverage control is generalized to players with nonlinear dynamics and in arbitrary dimensions. Pursuer coordination on defense surfaces is formally shown sufficient as a cooperative strategy for RA games in any dimensions. Nonlinear control synthesis strategies with convergence guarantees are provided to enforce coverage on said surfaces. The effectiveness of two coverage control formulations is verified through simulation.
The Even/Odd Synchronizer: A Fast, All-Digital, Periodic Synchronizer (2010)

We describe an all-digital synchronizer that moves multi-bit signals between two periodic clock domains with an average delay of slightly more than a half cycle and an arbitrarily small probability of synchronization failure. The synchronizer operates by measuring the relative frequency of the two periodic clocks and using this frequency measurement, along with a phase detection, to compute a phase estimate. Interval arithmetic is used for the phase estimate to account for uncertainty. The transmitter writes a pair of registers on alternating clock cycles and the receiver uses the estimate of the transmitter's phase to always select the most recently written value that is safe to sample. We show how to incorporate this design into a FIFO to give a fast periodic synchronizer with flow control. We present a number-theoretic argument that the synchronizer works for all frequency combinations. An implementation of the synchronizer using standard cells is also presented.
Encapsulating Bis(β-Ketoiminato) Polyethers. Volatile, Fluorine-Free Barium Precursors for Metal−Organic Chemical Vapor Deposition (2000)

The synthesis, characterization, and incorporation in volatile metal-organic chemical vapor deposition (MOCVD) precursors of a new class of linked beta-ketoiminate-polyether-beta-ketoiminate ligands is presented. These ligands are designed to encapsulate alkaline-earth cations having low charges and large ionic radii. Barium complexes having the general formula Ba[(RCOCHC(R')N)2(R")] (R = tert-butyl or CF3; R' = tert-butyl, methyl, or CF3; R" = -(CH2CH2O)4CH2CH2- or -(CH2CH2O)5CH2CH2)-) were prepared and characterized by 1H and 13C NMR spectroscopy, elemental analysis, and mass spectrometry. Single-crystal X-ray diffraction analysis of 2,2,5,25,28,28-hexamethyl-9,12,15,18,21-pentaoxa-4,25-diene-6,24- diimino-3,27-pentacosadionatobarium(II) reveals a monomeric, nine-coordinate, tricapped trigonal prismatic coordination geometry. Single-crystal X-ray structural analysis of 1,1,1,24,24,24-hexafluoro-4,21-ditrifluoromethyl-8,11,14,17- tetraoxa-3,21-diene-5,20-diimino-2,23-tetracosadionatobarium(II).2DMSO reveals a monomeric, ten-coordinate, distorted tetracapped trigonal prismatic coordination geometry. Volatility data are presented for these barium complexes, demonstrating viability as MOCVD precursors. In addition, it is demonstrated that thin epitaxial films of BaTiO3 can be grown on (001) MgO by low-pressure MOCVD techniques using one of these barium complexes and Ti(dipivaloylmethanate)2(isopropoxide)2 as precursors.
Field-modulated thermopower in SrTiO3-based field-effect transistors with amorphous 12CaO⋅7Al2O3 glass gate insulator (2009)

We report transistor characteristics and field-modulated thermopower (S) for single crystal SrTiO3-based field-effect transistors (FETs). We use 150-nm-thick amorphous 12CaO⋅7Al2O3 glass as the gate insulator of the SrTiO3-FET. The resulting SrTiO3-FET exhibits excellent transistor characteristics at room temperature: on-to-off current ratio greater than 106, threshold gate voltage of +1.1 V, subthreshold swing of approximately 0.3 V decade−1, and effective mobility of 2 cm2 V−1 s−1. The field-modulated S-value of the SrTiO3-FET varied from −900 to −580 μV K−1 with electric fields of up to 2 MV cm−1, demonstrating the effectiveness of the FET structure for the exploration of thermoelectric materials.
Neural correlates of efficacy of voice therapy in Parkinson's disease identified by performance–correlation analysis (2009)

LSVT LOUD (Lee Silverman Voice Treatment) is efficacious in the treatment of speech disorders in idiopathic Parkinson's disease (IPD), particularly hypophonia. Functional imaging in patients with IPD has shown abnormalities in several speech regions and changes in these areas immediately following treatment. This study serves to extend the analysis by correlating changes of regional neural activity with the main behavioral change following treatment, namely, increased vocal intensity. Ten IPD participants with hypophonia were studied before and after LSVT LOUD. Cerebral blood flow during rest and reading conditions were measured by H(2)(15)O-positron emission tomography. Z-score images were generated by contrasting reading with rest conditions for pre- and post-LSVT LOUD sessions. Neuronal activity during reading in the pre- versus post-LSVT LOUD contrast was correlated with corresponding change in vocal intensity to generate correlation images. Behaviorally, vocal intensity for speech tasks increased significantly after LSVT LOUD. The contrast and correlation analyses indicate a treatment-dependent shift to the right hemisphere with modification in the speech motor regions as well as in prefrontal and temporal areas. We interpret the modification of activity in these regions to be a top-down effect of LSVT LOUD. The absence of an effect of LSVT LOUD on the basal ganglion supports this argument. Our findings indicate that the therapeutic effect of LSVT LOUD in IPD hypophonia results from a shift in cortical activity to the right hemisphere. These findings demonstrate that the short-term changes in the speech motor and multimodal integration areas can occur in a top-down manner.
Experimental and numerical analyses of the effectiveness of high‐frequency peening processes (2017)

Abstract Dedicated to Prof. Dr. Akimitsu Kurita on his 70th birthday To assess fatigue behaviour, experimental tests were conducted on material specimens furnished with hammer peening tracks, with two different types of treatment being employed. The results of fatigue tests on treated specimens were compared with those of untreated specimens and assessed. Non‐linear analyses with the FE program ADINA, taking into account the stress–distortion behaviour of a material subjected to fatigue, were conducted as part of the test concept, specimen analysis, evaluation of the test results and probing the mode of action of both techniques.
High affinity of α-foetoprotein for arachidonate and other fatty acids (1980)

Fatty acid analysis of purified bovine alpha-foetoprotein showed it to contain 2.7 mol of fatty acid/mol of alpha-foetoprotein. Purified alpha-foetoprotein focused at isoelectric point 4.8. Removal of bound ligands from alpha-foetoprotein by charcoal treatment changed its isoelectric point to 5.2. This change could be reversed by addition of exogenous fatty acids to the defatted alpha-foetoprotein. Albumin isolated from the same foetal calf serum source as alpha-foetoprotein contained 1.4 mol of fatty acid/mol of protein. alpha-Foetoprotein and albumin contained comparable amounts of fatty acids with 14 to 18 carbon atoms, but alpha-foetoprotein contained 16 times as much of the long-chain polyunsaturated fatty acids as albumin. alpha-Foetoprotein was found to have slightly higher affinity for palmitate and linoleate and severalfold higher affinity for arachidonate than albumin. These findings suggest that alpha-foetoprotein may play a role in the foetal metabolism of the long-chain polyunsaturated fatty acids.
Influence of Oxygen Addition and Wafer Bias Voltage on Bromine Atom Surface Reaction in a HBr/Ar Inductively Coupled Plasma (2013)

The influence of the wafer surface material and wafer bias voltage on the Br radical density in HBr/Ar and HBr/Ar/O 2 inductively coupled plasmas was investigated by appearance mass spectrometry. By increasing the bias voltage, a monotonic decrease in the Br radical density was observed irrespective of the surface material (Si, Al 2 O 3 ) of the wafer. A drastic increase in Br radical density was observed after O 2 addition to HBr/Ar plasma in the case of a bare Si wafer, whereas almost the same density was observed in the case of an Al 2 O 3 -sputtered Si wafer. X-ray photoelectron spectroscopy (XPS) analysis indicated that O 2 addition promotes oxide formation on the Si surface. Measurement of the decay time constant for a Br radical after turning off the plasma indicated that O 2 addition results in a longer decay time constant, suggesting the decrease of the surface loss probability of Br radicals for the surface-oxidized Si surface.
Laser microchemical etching of silicon (1996)

Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
Determination of theX(3872)Meson Quantum Numbers (2013)

The quantum numbers of the X(3872) meson are determined to be J(PC)=1(++) based on angular correlations in B(+)→X(3872)K(+) decays, where X(3872)→π(+)π(-)J/ψ and J/ψ→μ(+)μ(-). The data correspond to 1.0 fb(-1) of pp collisions collected by the LHCb detector. The only alternative assignment allowed by previous measurements J(PC)=2(-+) is rejected with a confidence level equivalent to more than 8 Gaussian standard deviations using a likelihood-ratio test in the full angular phase space. This result favors exotic explanations of the X(3872) state.
3-Hydroxypyridin-2-thione as Novel Zinc Binding Group for Selective Histone Deacetylase Inhibition (2013)

Small molecules bearing hydroxamic acid as the zinc binding group (ZBG) have been the most effective histone deacetylase inhibitors (HDACi) to date. However, concerns about the pharmacokinetic liabilities of the hydroxamic acid moiety have stimulated research efforts aimed at finding alternative nonhydroxamate ZBGs. We have identified 3-hydroxypyridin-2-thione (3-HPT) as a novel ZBG that is compatible with HDAC inhibition. 3-HPT inhibits HDAC 6 and HDAC 8 with an IC50 of 681 and 3675 nM, respectively. Remarkably, 3-HPT gives no inhibition of HDAC 1. Subsequent optimization led to several novel 3HPT-based HDACi that are selective for HDAC 6 and HDAC 8. Furthermore, a subset of these inhibitors induces apoptosis in various cancer cell lines.
Hydrogenation-Induced Surface Polarity Recognition and Proton Memory Behavior at Protic-Ionic-Liquid/Oxide Electric-Double-Layer Interfaces (2010)

The electric-double-layer (EDL) formed at liquid/solid interfaces provides a broad and interdisciplinary attraction in terms of electrochemistry, photochemistry, catalysts, energy storage, and electronics. Especially in recent years, much effort has been devoted to the fundamental understanding and practical applications of transistor configurations with EDLs because of their ability for high-density charge accumulation. However, to exploit additional new functionalities of such an emerging interface is not only of great importance but also a huge challenge. Here, we demonstrate that, by introducing protic ionic liquid (PIL) as the gate dielectric for ZnO EDL transistors (EDLTs), small and chemically active ions, such as protons and hydroxyls, can serve as an adsorption medium to extend the interfacial functionalities of EDLTs. By selectively driving the H(+) or OH(-) groups onto ZnO channel surfaces with an electric field, the charged adsorbates interact with surface atoms in different adsorption mechanisms, showing remarkable variations in electron transport and providing a possibility for the recognition of surface polarity. Most significantly, the large hysteresis in the transfer characteristics of PIL-EDLTs makes the device available and promising for nonvolatile proton memory devices via surface hydrogenation and dehydrogenation processes. Such a finding provides us with new opportunities to understand liquid/solid heterogeneous interface phenomena and to extend the practical functions of EDLs through controllable interfacial interaction.
Intestinal capillary filtration in experimental diabetes mellitus (1987)

There is indirect evidence that indicates that intestinal transcapillary fluid and solute exchange is significantly altered in diabetes mellitus. To directly assess the dynamics of microvascular fluid and solute exchange in the small intestine (jejunum-ileum), we measured lymph flow, capillary pressure, capillary filtration coefficient, plasma and lymph oncotic pressures, and the osmotic reflection coefficient in anesthetized, fasted control rats and in rats in which diabetes was induced by a single injection of streptozotocin (65 mg/kg ip) 4 wk before the experiments. Diabetes was associated with an increase in lymph flow (by 120%), capillary pressure (by 34%), and capillary filtration coefficient (by 75%) when compared with values from control rats. The transcapillary oncotic pressure gradient was not altered by diabetes. Interstitial fluid pressure, calculated from the measured parameters in the Starling equation, was increased from -1.6 mmHg in control rats to +2.5 mmHg in diabetic animals. Analysis of lymph-to-plasma protein concentration ratios at various lymph flows suggests that the osmotic reflection coefficient in the diabetic intestine is comparable to that obtained in control animals. The results of this study indicate that experimental diabetes mellitus is associated with increases in intestinal capillary pressure and capillary filtration rate but that intestinal capillary permeability is not altered in this disorder.
Move it there, or not? (2012)

This paper presents an experiment that was conducted to investigate gaze combined with voice commands. There has been very little research about the design of voice commands for this kind of input. It is not known yet if users prefer longer sentences like in natural dialogues or short commands. In the experiment three different voice commands are compared during a simple task in which participants had to drag & drop, rotate, and resize objects. It turned out that the shortness of a voice command -- in terms of number of words -- is more important than it being absolutely natural. Participants preferred the voice command with the fewest words and the fewest syllables. For the voice commands which had the same number of syllables, the users also preferred the one with the fewest words, even though there were no big differences in time and errors.
Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro (2014)

The use of human whole blood for transcriptomic analysis has potential advantages over the use of isolated immune cells for studying the transcriptional response to pathogens and their products. Whole blood stimulation can be carried out in a laboratory without the expertise or equipment to isolate immune cells from blood, with the added advantage of being able to undertake experiments using very small volumes of blood. Toll like receptors (TLRs) are a family of pattern recognition receptors which recognise highly conserved microbial products. Using the TLR2 ligand (Pam3CSK4) and the TLR4 ligand (LPS), human whole blood was stimulated for 0, 1, 3, 6, 12 or 24 hours at which times mRNA was isolated and a comparative microarray was undertaken. A common NFκB transcriptional programme was identified following both TLR2 and TLR4 ligation which peaked at between 3 to 6 hours including upregulation of many of the NFκB family members. In contrast an interferon transcriptional response was observed following TLR4 but not TLR2 ligation as early as 1 hour post stimulation and peaking at 6 hours. These results recapitulate the findings observed in previously published studies using isolated murine and human myeloid cells indicating that in vitro stimulated human whole blood can be used to interrogate the early transcriptional kinetic response of innate cells to TLR ligands. Our study demonstrates that a transcriptomic analysis of mRNA isolated from human whole blood can delineate both the temporal response and the key transcriptional differences following TLR2 and TLR4 ligation.