gebhart/patrepeval huggingface dataset:
P377 Impact of moderate-to-severe endoscopic disease criteria on endoscopic response, endoscopic remission, and deep remission in patients receiving ustekinumab or adalimumab in the SEAVUE study (2022)

Abstract Background Entry criteria and outcome measures of Crohn’s disease (CD) clinical trials have evolved. Patients are now required to have active inflammation on screening endoscopy, with some studies requiring moderate-severe SES-CD scores. Recent trials have endoscopic response as a co-primary endpoint and endoscopic remission (ER) and deep remission (DR) as major secondary endpoints. Pivotal CD maintenance studies typically examine only responders to induction. The SEAVUE study required ≥1 ulceration of any size (SES-CD≥3) at baseline and had a treat-through design. To examine the results in the context of these trial design characteristics, we evaluated endoscopic outcomes at wk52 in the subgroup of pts with moderate-severe baseline SES-CD scores in SEAVUE, as well as those who were in clinical response after induction. Methods Biologic-naïve pts failing or intolerant to conventional therapy with CDAI≥220/≤450 and SES-CD≥3 were eligible. Pts were randomized, 1:1 to UST (~6mg/kg IV at wk0 then, 90mg SC q8w) or ADA (SC, 160mg at wk0, 80mg at wk2, then, 40mg q2w). Endoscopic outcomes were evaluated in all pts and the subgroup with moderate-severe endoscopic disease (baseline SES-CD≥6 for ileocolonic or colonic disease or SES-CD≥4 for isolated ileal disease). Endoscopic response was a ≥50% reduction from baseline in SES-CD, SES-CD≤3, or SES-CD=0 for pts with baseline SES-CD=3. ER was SES-CD≤3 or, 0 in pts with baseline SES-CD=3. DR was CDAI&amp;lt;150 and ER. Results Endoscopic outcomes for the subgroup with moderate-severe endoscopic disease were similar to those of the full cohort of pts. In UST-treated pts, endoscopic response was achieved at wk52 in, 41.9% in the full cohort and, 43.1% in the moderate-severe subgroup (Table, 1). In ADA-treated pts, endoscopic responses were, 36.9% and, 35.4%, respectively. For pts who were in clinical response after induction (Table, 1), endoscopic response rates were, 48.2% in the full cohort and, 49.5% in the moderate-severe subgroup for UST and, 44.8% and, 43.1%, respectively, for ADA. ER and DR rates were generally similar between the full cohort and the moderate-severe subgroup (Table, 2; eg, ERs were UST, 28.5% and ADA, 30.7% in full cohort; UST, 27.1% and, 27.8% ADA in subgroup). ER and DR rates were, 3%-7% higher in induction responders compared with the full cohort. Of note, even among wk16 nonresponders, some pts attained endoscopic outcomes at wk52 (eg, endoscopic responses in wk16 nonresponders were UST, 21.4% and ADA 13.3%). Conclusion In SEAVUE, both the UST and ADA treatment groups achieved high endoscopic response, ER, and DR rates at wk52. Results in pts with moderate-severe endoscopic disease were similar to those of the full cohort, but clinical responders after induction had higher rates than the full cohort.
Electron-phonon scattering in β -Ga2O3 studied by ultrafast transmission spectroscopy (2021)

Femtosecond pump-probe experiments in a transmission geometry were performed on Sn-doped n-type β-Ga2O3. With the pump and probe wavelengths below the bandgap, the differential transmission signal was determined by the free electron dynamics. Differential transmission decay times and their spectral dependence were used to evaluate electron-phonon scattering for polar optical (PO) and intervalley phonons. The obtained average electron-PO phonon scattering time is 4.5 ± 0.4 fs, while the electron scattering to and from the side valley is 80 ± 5 fs. The energy between the absolute and second lowest conduction band minima is estimated to be 2.6 ± 0.1 eV.
Qualitative analysis of mathematical expressions using computer symbolic mathematics (1976)

Increasingly powerful computers and simplification algorithms permit us to obtain answers for increasingly complex computer-algebra problems. Consequently, we will continue to get results which often are incomprehensibly lengthy and complicated. However, a user of computer-algebra systems need not abandon hope when faced with such results. Often the user is interested in qualitative properties of a result rather than details of an analytical representation of the result. For example, is the result real? bounded? even? continuous? positive? monotonic? differentiable? or convex? Where, if any, are the singularities, zeros, and extrema? What are their orders? What is the local behavior in the neighborhood of these notable features, as exhibited perhaps by series expansions? Are there simple asymptotic representations as certain variables approach infinity?
Domain configurations due to multiple misfit relaxation mechanisms in epitaxial ferroelectric thin films. II. Experimental verification and implications (1994)

In part I, the concept of a temperature dependent domain stability map was developed for tetragonal ferroelectrics grown on cubic substrates. In this paper, a range of experimental data on domain populations in heteroepitaxial ferroelectric films is placed in the context of the stability map. Experimental data shows that differential thermal expansion, cooling rate, and applied electric fields may be effectively used to control domain structure, particularly in the system PZT, PZT/YBCO/LaAlO3, and LSCO/PLZT/LSCO/LaAlO3. It will be shown that misfit dislocations generated during growth screen the majority of the lattice mismatch with the substrate. Thus, the variety of domain patterns that develop during the Curie transition depend on processing parameters and can be successfully explained by applying the temperature dependent coherent domain stability map developed in part I.
A New Synthesis of cis-Cyclobut-3-ene-1,2-dicarboxylic Anhydride (1999)

International audience
Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues (1999)

Laser scanning confocal autofluorescence microscopy (LSCAM) using 351- to 364-nm excitation light was used to quantitatively compare fluorescent spectral emission of unstained, frozen histological sections of normal, premalignant, and malignant colonic tissues. To identify the spatial origins of fluorescent signals accurately, the same frozen section slides used for microscopy were fixed and histochemically stained immediately following LSCAM imaging. Tissue fluorescence emission was quantified in terms of the intrinsic fluorescence coefficient beta (lambda), defined as the fluorescence power per unit tissue volume per unit wavelength (centered at lambda) divided by the incident light irradiance. Over all emission wavelengths, colonic tissues emitted autofluorescence ranging from beta (lambda) approximately 10(-1.5) to 10(-3.0) cm-1. In the 530- to 610-nm spectral region, markedly increased autofluorescence (beta up to 10(-2.5)) was observed in the dysplastic cells of adenomatous polyps, as compared to normal epithelial cells. Compared to adenomatous polyps, decreased dysplastic cell autofluorescence was observed in adenocarcinoma. The brightest fluorescence in the lamina propria, which was attributed to eosinophils (beta approximately 10(-2.5)) in previous studies, was also observed in other granular structures (beta up to 10(-1.4)). LSCAM reveals quantitative significant differences in fluorescence emission between normal and diseased colonic tissues.
Managerial IT unconsciousness (2006)

A poorly designed, carelessly implemented, irresponsibly managed system can lead to company failure, along with IT failure.
Towards practical design rules for quantum communications and quantum imaging devices (2005)

A common syndrome in much of the current quantum optics and quantum computing literature is the casual switching between classical concepts (e.g., geometric rays, electromagnetic waves) and quantum concepts (e.g., state vectors, projection operators). Such ambiguous language can confuse designers not well versed in the deeper subtleties of quantum mechanics, or worse, it can lead to a flawed analysis of new designs for quantum devices. To validate that a quantum device can be constructed with the expected characteristics and that its quantum effects are correctly interpreted, a set of unambiguous design rules would be useful. In this paper we enumerate such a set of easily applied quantum rules in the hope that they might facilitate clearer communication between researchers and system developers in the field. In part, we are motivated by recently reported interferometer results that have not only led to flawed claims about disproving fundamental quantum principles, but have elicited equally flawed counter aruments from supposedly knowledgeable respondents. After one hundred years of testing Einstein's photon, it is alarming that such widespread confusion still persists. Our proposed quantum design rules are presented in a practical diagrammatic style, demonstrating their effectiveness by analyzing several interferometers that have appeared in the recent literature. Application to other quantum devices e.g., quantum ghost imaging, are also discussed. We stress that these rules are entirely quantum in prescription, being particularly appropriate for single-photon devices. Classical optics concepts e.g., refractive index, are not required since they are subsumed by our quantum rules.
Magneto-THz spectroscopy in spinel superconductor LiTi<inf>2</inf>O<inf>4</inf> thin films (2017)

We investigate a spinel superconductor, LiTi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> using continues wave(CW) terahertz spectroscopy combined with THz TDS under magnetic fields. We observed a clear superconducting gap opening in about 0.4THz and a residual real part of the conductivity below the superconducting phase transition temperature, which indicates a pair-breaking effect. It was the first time that the superconducting gap was observed in the strong spin fluctuation compounds LiTi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> by a continues wave terahertz spectroscopy.
Effective direct recycling of inhomogeneously aged Li-ion battery cathode active materials (2023)

There is growing interest in lithium ion battery materials recycling, and specifically direct recycling, wherein the cathode material is harvested and rejuvenated for use in new batteries. A key risk associated with this process is the fact that materials collected from aged batteries will be inhomogeneous due to the variable experience they incur during use, both between cells and even within cells themselves. In this paper, we investigate the direct recycling process factors that address the effect of three properties of aged and harvested LiNi0.815Co0.15Al0.035O2 (NCA) materials: variation of state-of-charge (SoC), the inconsistent existence of a surface reconstruction layer on the material, and the inhomogeneous growth of the solid electrolyte interface (SEI). We will explore how each property impacts the consistency of the recycled NCA in terms of several key materials properties.
Watt-level, gigahertz-linewidth difference-frequency generation in PPLN pumped by an nanosecond-pulse fiber laser source (2015)

We obtained >1 W average power and up to 5 μJ pulse energy at ∼3520 nm wavelength via difference-frequency generation (DFG) of an all-fiber, few-ns pulse, variable pulse-repetition-frequency laser source operating at 1064 nm and 10 mW, continuous-wave, 1525 nm single-frequency diode laser, within a 5 cm-long periodically poled lithium niobate (PPLN) crystal. To the best of our knowledge, this result amounts to the highest-average-power, spectrally bright mid-infrared radiation obtained via DFG.
Expression of inflammatory cytokines and adhesion molecules in haemodialysis-associated amyloidosis (1995)

These data suggest that upregulated expression of inflammatory cytokines and adhesion molecules promotes activation and infiltration of macrophages causing CTS in haemodialysis-associated amyloidosis patients.
One-Component Approximation for Binary Diblock Copolymer Blends (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleOne-Component Approximation for Binary Diblock Copolymer BlendsM. W. Matsen and F. S. BatesCite this: Macromolecules 1995, 28, 21, 7298–7300Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ma00125a041https://doi.org/10.1021/ma00125a041research-articleACS PublicationsRequest reuse permissionsArticle Views397Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electronic and thermal properties of Ti3Al(C0.5,N0.5)2, Ti2Al(C0.5,N0.5) and Ti2AlN (2008)

In this paper we report on the electronic, magnetotransport, thermoelectric, and thermal properties of Ti3Al(C0.5,N0.5)2, Ti2Al(C0.5,N0.5), and Ti2AlN. The electrical conductivities, Hall coefficients, and magnetoresistances are analyzed within a two-band framework and compared with the end members, Ti2AlC and Ti3AlC2. The analysis shows that all compounds are compensated conductors with hole and electron carrier densities of about 1.5×1027 m−3. The room temperature thermal conductivities of the carbonitrides are both over ≈50 W/mK, with the phonon contribution of Ti3Al(C0.5,N0.5)2 particularly large at over 35 W/mK. The low-temperature specific heat of Ti3Al(C0.5,N0.5)2 and Ti2Al(C0.5,N0.5) yield Debye temperatures of 685 and 724 K, respectively, comparable to those of the end members.
Evaluation of Zirconium and Hafnium Complexes that Contain the Electron-Withdrawing Diamido/Donor Ligand [(2,6-Cl2C6H3NCH2CH2)2NCH3)]2- for the Polymerization of 1-Hexene (2005)

The triamine (2,6-Cl2C6H3NHCH2CH2)2NMe (H2[ArClN2NMe]) can be prepared through the Pd-catalyzed coupling between 2-bromo-1,3-dichlorobenzene and (H2NCH2CH2)2NH to give (2,6-Cl2C6H3NHCH2CH2)2NH, followed by methylation of the central nitrogen with MeI. Zirconium and hafnium complexes that were prepared include [ArClN2NMe]M(NMe2)2 (M = Hf or Zr), [ArClN2NMe]MCl2, [ArClN2NMe]MMe2, [ArClN2NMe]HfCl(i-Bu), [ArClN2NMe]HfMe(i-Bu), and [ArClN2NMe]Hf(i-Bu)2. An X-ray crystal structure shows [ArClN2NMe]Hf(i-Bu)2 to be a square pyramid in which one of the isobutyl groups occupies the apical position. Activation of dimethyl species with {Ph3C}{B(C6F5)4}, B(C6F5)3, or {PhNMe2H}{B(C6F5)4} yielded {[ArClN2NMe]MMe}+ cations paired with {B(C6F5)4}- or {MeB(C6F5)3}- anions; these species are active for the polymerization of 1-hexene. Activation of [ArClN2NMe]Hf(i-Bu)2 with {Ph3C}{B(C6F5)4} or B(C6F5)3 produced {[ArClN2NMe]Hf(i-Bu)}{B(C6F5)4} and {[ArClN2NMe]Hf(i-Bu)}{HB(C6F5)3}, which are also active for the polymerization of 1-hexene. Isobutene was found to insert slowly into the M−R bond of these initiators in a 1,2 manner and was oligomerized at high concentrations of isobutene. Activation of [ArClN2NMe]HfMe(i-Bu) with B(C6F5)3 resulted in selective abstraction of a methyl group to generate 95% {[ArClN2NMe]Hf(i-Bu)}{MeB(C6F5)3}. The rate of consumption of 1-hexene followed a first-order dependence on 1-hexene (and hafnium or zirconium), and zirconium was faster than hafnium. Although poly[1-hexene] generated by the zirconium catalyst was characteristic of a living system, significant β-hydride elimination was observed in polymerizations by hafnium catalysts. The hafnium product of β-hydride elimination was observed to reinitiate the polymerization of 1-hexene. We conclude that by replacing the mesityl substituents in the analogous [(MesitylN2NMe]2- ligand with 2,6-Cl2C6H3 groups, decomposition is attenuated significantly, although living behavior is observed for zirconium catalysts only.
Why do verification approaches in automation rarely use HIL-test? (2013)

Nowadays, model-driven formal verification approaches are much researched for testing industrial control applications. However, these approaches can't check the system for bus errors, faulty hardware configurations and compatibility problems efficient. For sufficient testing, Hardware-in-the-Loop (HIL) test should be used. But the HIL-test is rarely used in the field of automation because of missing experience with it and great costs by using vendor-dependent solutions. This paper will discusses the current problems of HIL-tests for verifying the control applications and presents a promising vendor-independent approach for its implementation.
SpeedGate: A smart data pricing testbed based on speed tiers (2013)

The explosive growth of cellular traffic and its highly dynamic nature often make it increasingly expensive or even infeasible for a cellular service provider to provision enough cellular resources to support the peak traffic demands. Some service providers have started exploring various economic incentives, including smart data pricing, to manage network congestion. We present SpeedGate, a smart mobile data pricing testbed that allows a service provider to experiment with different dynamic pricing strategies. SpeedGate maintains persistent VPN connections to smartphones as users roam between different wireless networks (3G, 4G/LTE, WiFi). The maximum available bandwidth per user session can be adjusted according to various data pricing strategies. We report preliminary results on two trials with a total of 29 users for assessing their willingness to pay (WTP) for various speed tiers. Preliminary observations suggest the challenges of QoS guarantees through speed tiers in the field, the limited dynamic range of WTP values from individual users for different speed tiers, and potential opportunities for auction-based dynamic pricing.
Supplementary Figure S1 from NAP1051, a Lipoxin A4 Biomimetic Analogue, Demonstrates Antitumor Activity Against the Tumor Microenvironment (2023)

&lt;p&gt;Figure S1 shows the gating strategy for PMN apoptosis analysis, RT-PCR, immunofluorescence staining, and flow cytometry analyses of FPR2/ALX-transfected HEK cells, effect of NAP1051 on dTHP-1 cells with selective kinase inhibitors, and Western blot with normal HEK cells and FPR2/ALX-transfected HEK cells&lt;/p&gt;
NADPH‐dependent 5‐keto‐D‐gluconate reductase is a part of the fungal pathway for D‐glucuronate catabolism (2017)

NADPH-dependent 5-keto-D-gluconate reductase was identified as a missing element in the pathway for D-glucuronate catabolism in fungi. The disruption of the gene, gluF, by CRISPR/Cas9 in the filamentous fungus Aspergillus niger resulted in a strain unable to catabolise D-glucuronate. The purified GluF protein was characterized and k<sub>cat</sub> and K<sub>m</sub> values of 23.7 ± 1.8 s<sup>-1</sup> and 3.2 ± 0.1 mm for 5-keto-D-gluconate, respectively, were determined. The enzyme is reversible and is active with NADP<sup>+</sup> and D-gluconate. We suggest a pathway for D-glucuronate catabolism with the intermediates L-gulonate, 2-keto-L-gulonate, L-idonate, 5-keto-D-gluconate, D-gluconate and D-gluconate-6-phosphate which is a part of the pentose phosphate pathway. A fungal enzyme activity for the conversion of L-gulonate to 2-keto-L-gulonate remains to be identified.
A Visual Analytics Field Experiment to Evaluate Alternative Visualizations for Cyber Security Applications (2014)

The analysis and exploration of emerging threats in the Internet is important to better understand the behaviour of attackers and develop new methods to enhance cyber security. Fully automated algorithms alone are often not capable of providing actionable insights about the threat landscape. We therefore combine a multi-criteria clustering algorithm, tailor-made for the identification of such attack campaigns with three interactive visualizations, namely treemap representations, interactive node-link diagrams, and chord diagrams, to allow the analysts to visually explore and make sense of the resulting multi-dimensional clusters. To demonstrate the potential of the system, we share our lessons learned in conducting a field experiment with experts in a security response team and show how it helped them to gain new insights into various threat landscapes.
Automated assembly inspection using a multiscale algorithm trained on synthetic images (2002)

An important part of a robust automated assembly process is an accurate and efficient method for the inspection of finished assemblies. This paper presents a novel multiscale assembly inspection algorithm that is used to detect errors in an assembled product. The algorithm is trained on synthetic images generated using the CAD model of the different components of the assembly. The CAD model guides the inspection algorithm through its training stage by addressing the different types of variations that occur during manufacturing and assembly. Those variations are classified into those that can affect the functionality of the assembled product and those that are unrelated to its functionality. Using synthetic images in the training process adds to the versatility of the technique by removing the need to manufacture multiple prototypes and control the lighting conditions. Once trained on synthetic images, the algorithm can detect assembly errors by examining real images of the assembled product. The effectiveness of the system is illustrated on a typical mechanical assembly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mixed reality technologies for immersive interactive broadcast (2016)

Up until now, TV has been a one-to-many proposition apart from a few exceptions. The TV Stations produced and packaged their shows and the consumers had to tune in at a specific time to watch their favourite show. However, new technologies are changing the way we watch and produce television programs. For example, viewers often use second screen applications and are engaged in lively discussions via social media channels while watching TV. Nevertheless, immediate live interaction with broadcast media is still not possible. In this paper, the latest results of the European funded project ACTION-TV, which is developing novel forms of user interaction based on advanced Computer Vision and Mixed-Reality technologies, are presented. The aim of this research project is to let viewers actively participate in pre-produced live-action television shows. This expands the horizon of the interactive television concept towards engaging television shows. The paper explains the concept, challenges and solutions resulting in a first prototype real-time demonstrator for novel interactive TV services.