gebhart/patrepeval huggingface dataset:
Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion (2022)

ABSTRACT Synaptotagmin 9 (SYT9) is a tandem C2-domain Ca 2+ sensor for exocytosis in neuroendocrine cells; its function in neurons remains unclear. Here, we show that endogenous SYT9 does not trigger rapid synaptic vesicle exocytosis in cultured cortical, hippocampal, or striatal neurons; rather, synaptotagmin 1 (SYT1) fulfills this function. SYT9 is able to regulate evoked synaptic vesicle exocytosis, but only when massively over-expressed. In striatal neurons, loss of SYT9 reduced the rate of spontaneous miniature neurotransmitter release events (minis). To delve into the underlying mechanism, we localized SYT9 within these neurons and found that it is targeted to dense core vesicles, where it regulates the release of substance P (SP), a neuropeptide known to modulate mini frequency. Exogenous SP, but not other striatal peptide hormones, completely rescued the Syt9 KO mini phenotype. Biochemical experiments revealed that Ca 2+ -binding to the C2A domain of SYT9 triggers membrane fusion in vitro , and mutations that disrupt this activity abolished the ability of SYT9 to regulate both SP release and mini frequency in striatal neurons. We conclude that SYT9 indirectly regulates synaptic transmission in striatal neurons by controlling SP release.
High Spatial Density 6-Mode 7-Core Fiber Amplifier for L-Band Operation (2020)

We present a high spatial density space division multiplexed fiber amplifier (i.e., 6-mode 7-core multicore fiber amplifier) supporting 42 spatial channels. A high average modal gain of 23.1 dB is obtained in the L-band with an average differential modal gain of 3.2 dB and a minimum output power of 17.5 dBm per core per mode. The total power consumption of the amplifier is improved by a power reduction factor of 0.36 and a fully fiberized optical amplifier is realized in a cladding-pumped configuration. The assembled amplifier is then tested in a few-mode multicore fiber transmission link and simultaneously amplified 42 spatial channel fiber transmission is demonstrated with the highest spatial density and energy efficiency to date.
Modal response uncertainty in structural acoustic systems using generalized polynomial chaos expansion (2017)

When knowledge of material design parameters is lacking, it is important to understand how this uncertainty effects the system response. Generalized polynomial chaos (gPC) expansions provide a means for quantifying this uncertainty and typically show good agreement with Monte Carlo techniques at a much reduced cost [K. Sepahvand et al. / Applied Acoustics 87 (2015) 23-29]. In this work, we apply gPC expansions to study the effects of design parameter uncertainty on a structure’s modal characteristics—both eigenvalues and eigenfunctions. The gPC expansions permit the propagation of uncertainty from the design parameters to the modes and natural frequencies, which then characterize the vibration response of the system as a function of the random parameters. The response uncertainty can then be described using the solutions of the deterministic system sampled carefully over the parameter space. Uncertainty in the forcing function can also be included in this formulation. Numerical calculations demonstrate these techniques to predict the structural acoustic uncertainty of a vibrating plate with the results validated against Monte Carlo simulations. The effects of uncertain forcing functions will also be discussed.
Real-Time and Low-Power Streaming Source Separation Using Markov Random Field (2018)

Machine learning (ML) has revolutionized a wide range of recognition tasks, ranging from text analysis to speech to vision, most notably in cloud deployments. However, mobile deployment of these ideas involves a very different category of design problems. In this article, we develop a hardware architecture for a sound source separation task, intended for deployment on a mobile phone. We focus on a novel Markov random field (MRF) sound source separation algorithm that uses expectation-maximization and Gibbs sampling to learn MRF parameters on the fly and infer the best separation of sources. The intrinsically iterative algorithm suggests challenges for both speed and power. A real-time streaming FPGA implementation runs at 150MHz with 207KB RAM, achieves a speed-up of 22× over a software reference, performs with an SDR of up to 7.021dB with 1.601ms latency, and exhibits excellent perceived audio quality. A 45nm CMOS ASIC virtual prototype simulated at 20MHz shows that this architecture is small (&lt;10 million gates) and consumes only 70mW, which is less than 2% of the power of an ARM Cortex-A9 software version. To the best of our knowledge, this is the first Gibbs sampling inference accelerator designed in conventional FPGA/ASIC technology that targets a realistic mobile perceptual application.
Analysis of channel characteristics for motor cable communication with inductive signal coupling (2010)

It has been shown that power line communication (PLC) is a feasible method for data transmission between a low-voltage (LV) motor and a frequency converter through the power cable. In this paper, attenuation and noise power spectrum of the communication channel are analyzed. The analysis is based on a laboratory test setup, laboratory measurements, simulation models, and known power spectral density (PSD) limits for commercial PLC equipment. Based on the analysis, a feasible frequency band for the motor cable communication with an inductive coupling circuit and without inverter output filter is proposed for different cable lengths covering typical lengths used in industrial LV motor drive applications.
Elastomeric Polypropylene from Unbridged 2-Arylindenyl Zirconocenes:  Modeling Polymerization Behavior Using ansa-Metallocene Analogues (1998)

Bis(2-arylindenyl)zirconium dichlorides activated by methylaluminoxane (MAO) produce elastomeric polypropylene. The elastic properties of this material are proposed to arise from a stereoblock microstructure. The silyl bridged catalysts rac- and meso-dimethylsilyl(bis(2-phenylindenyl))zirconium dichloride were prepared and used to model the polymerization behavior of the unbridged catalysts. The meso isomer is approximately twice as productive as the rac isomer in propylene polymerization. Additionally, blends of isotactic and atactic polypropylene were prepared by using varying amounts of the rac and meso isomers until the IR and NMR characteristics matched polypropylenes produced from bis(2-phenylindenyl)zirconium dichloride. These studies suggest (1) that the rac isomer is favored in the isomerization equilibrium for the unbridged catalysts and (2) that the larger fraction of atactic polymer in the elastomeric polypropylene is a consequence of the higher rate of polymerization for the meso isomer.
Joint Linearization for Radio-over-Fiber Links Equipped with High Power Amplifiers (2016)

In this study, we experimentally investigated the adjacent channel leakage ratio (ACLR) performance degradation for the output signal of the RF HPA equipped with the adaptive linearization caused by RoF links placed in both direct and feedback paths of the transmitting system. We show that ACLR exceeding -57 dBc @ 5 MHz offset, which completely satisfy the requirement defined in the 3GPP technical specification, can be achieved for a 20 W class Doherty power amplifier linearized through 1 km fiber with commercial RoF links. With the experimental results, we show that the achieved ACLR strongly depends on the RoF link noise figure; meanwhile most of the nonlinear distortions caused by RoF can be successively suppressed with the proposed joint linearization approach.
Impact of N-substitution of a carbazole unit on molecular packing and charge transport of DPP–carbazole copolymers (2013)

Two diketopyrrolopyrrole (DPP)–carbazole (Cz) based π-conjugated copolymers, PDBTCz-H (P1) and PDBTCz-Me (P2), were designed and synthesized to study the effects of N-substitution of the carbazole unit on the molecular ordering, main chain conjugation, and charge transport properties of these polymers. It was found that the existence of hydrogen bonding interaction between the N–H group in the carbazole unit and the CO group in the DPP unit has a significant impact on the UV absorption, crystallinity, thin film morphology, as well as charge transport characteristics of P1. The hydrogen bonding is a very competitive force with the π–π stacking interaction, leading to the more twisted backbone structure and poorer molecular ordering of P1 in the solid state. Although the crystallinity of the P1 thin films could be somewhat improved by thermal annealing, the polymer main chains of P1 remain rather twisted and less conjugated in comparison with P2. The poorer main chain conjugation of P1 caused by the hydrogen bonding led to a dramatic drop in charge transport performance in organic thin film transistors (OTFTs). The highest hole mobility achieved for P1 is 8.9 × 10−3 cm2 V−1 s−1, which is almost two orders of magnitude lower than that of P2 (0.53 cm2 V−1 s−1).
Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.8.2410 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8708739 Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. G A FyfexG A FyfeSearch for articles by this author , R I FisherxR I FisherSearch for articles by this author , S A RosenbergxS A RosenbergSearch for articles by this author , M SznolxM SznolSearch for articles by this author , D R ParkinsonxD R ParkinsonSearch for articles by this author , A C LouiexA C LouieSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.8.2410 PDF "Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy.." Journal of Clinical Oncology, 14(8), pp. 2410–2411© 1996 by American Society of Clinical Oncology
StyleProp: Real‐time Example‐based Stylization of 3D Models (2020)

Abstract We present a novel approach to the real‐time non‐photorealistic rendering of 3D models in which a single hand‐drawn exemplar specifies its appearance. We employ guided patch‐based synthesis to achieve high visual quality as well as temporal coherence. However, unlike previous techniques that maintain consistency in one dimension (temporal domain), in our approach, multiple dimensions are taken into account to cover all degrees of freedom given by the available space of interactions (e.g., camera rotations). To enable interactive experience, we precalculate a sparse latent representation of the entire interaction space, which allows rendering of a stylized image in real‐time, even on a mobile device. To the best of our knowledge, the proposed system is the first that enables interactive example‐based stylization of 3D models with full temporal coherence in predefined interaction space.
CMOS-compatible, Ge-SiO2 core-shell nanowire for label-free, highly sensitive detection of cancer biomarker (2016)

In this study, arrays of controllable, Ge-SiO2 core-shell structure nanowire (NW) were fabricated by combining the complementary metal-oxide semiconductor (CMOS) compatible technology and Ge-condensation technology. Meanwhile, based on this novel nanostructure, the biosensor application in label-free, highly sensitive detection of lung cancer biomarker was investigated. This nanosensor illuminated highly sensitive concentration dependent conductance change in response to targets and had high specificity in one-base mismatched target DNA discrimination.
Magnetite-embedded cellulose fibers prepared from ionic liquid (2007)

A dry-jet wet spinning process for making magnetically active cellulose fibers has been developed using the ionic liquid (IL) 1-ethyl-3-methylimidazolium chloride ([C2mim]Cl). Cellulose from different sources with various degrees of polymerization (DP) was used for making fibers by first dissolving the cellulose in the IL, dispersing particles of magnetite in the solution, and then coagulating the fibers in a water bath under appropriate spinning conditions. The variation of fiber properties with cellulose source and concentration of magnetite is discussed. Fiber texture was found to be related to overall magnetite concentration, cellulose concentration, and molecular weight in the spinning solution. In general, it was found that increasing DP and/or cellulose concentration resulted in more robust fibers, and conversely the addition of magnetite particles weakened the overall mechanical properties.
ChemInform Abstract: Diastereoselective Synthesis und Molecular Structure of 2,3‐Dihydrobenzofuran Derivatives. (1985)

Abstract Die vinylogen Amide (I) reagieren mit dem Chinon (II) regio‐ und stereospezifisch zu den Benzofuranderivaten (III) (Diskussion des Reaktionsverlaufs).
Motion and Mode Mapping for MPEG-2 to H.264/AVC Transcoding (2006)

This paper describes novel low-complexity transcoding techniques for an efficient MPEG-2 to H.264/AVC transcoder. We present a motion and mode mapping algorithm that directly maps incoming MPEG-2 motion information to H.264/AVC motion vectors as well as coding modes. Refinement strategies are also presented to improve performance. Experiment results demonstrate the effectiveness of the proposed low-complexity transcoder
CELL BIOLOGY AND SIGNALING (2013)

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in a variety of tissue including the brain, suggesting that Ikaros may be involved in the physiological functions of glial growth. Other recent studies have shown that Ikaros can regulate the transition of neural progenitor cells to postmitotic neurons which eventually differentiate into glial cells. Deregulation of glial development and/or growth has been shown to initiate glioblastoma (GBM) growth suggesting that Ikaros may be involved in GBM tumorigenesis. The goal of this study was to determine if Ikaros plays an important role in glial tumorigenesis. Analysis using the TCGA and Rembrandt databases demonstrated that decreased expression of Ikaros leads to worse prognosis in GBM patients (P , 0.01). In addition, the Ikaros promoter was found to be hypermethylated (85% of samples) in GBM samples suggesting that inhibition of Ikaros may contribute to glial tumorigenesis. To determine if Ikaros is involved in glial tumorigenesis we generated stable GBM cell lines that were transduced with HA-Ikaros. Enhanced expression of Ikaros resulted in a 3-to 4-fold reduction in proliferation and a 2-to 3-fold reduction in colony formation. In addition, exogenous expression of Ikaros inhibited the migration of GBM cells suggesting that Ikaros may also be involved in the invasiveness of glial cancers. Together our data suggests that Ikaros may play an important role in suppressing glial tumor formation and may be a novel biomarker for GBMs.
High-temperature stable fiber Bragg gratings with ultrastrong cladding modes written using the phase mask technique and an infrared femtosecond laser (2019)

Bragg gratings with ultrastrong cladding modes are inscribed in a standard telecom optical fiber (i.e., SMF-28) using the phase mask technique and an infrared femtosecond laser. 1000°C-resistant fiber Bragg gratings (FBGs) whose cladding modes exceed 30 dB in transmission and spectrally span more than 250 nm can be produced with only a few (i.e., less than five) laser pulses, provided that the light intensity in the fiber core is kept at the level of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>∼</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>6</mml:mn> </mml:mrow> <mml:mo>×</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>10</mml:mn> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>13</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">W</mml:mi> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>/</mml:mo> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">c</mml:mi> <mml:mi mathvariant="normal">m</mml:mi> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> . The use of FBGs fabricated under the above conditions for refractometry is demonstrated.
Thermally tunable SOI CMOS photonics circuits (2010)

Ring waveguide resonating structures with high quality factors are the key components in the silicon photonics portfolio boosting up its functionality and circuit performance. Due to a number of manufacturing reasons their peak wavelengths are often prone to deviate from designed values. In order to keep the ring resonator operating as specified, its peak wavelength then needs to be corrected in a reliable and power efficient way. We demonstrate the performance of the thermally tunable mux/demux filter ring structures fabricated in the commercial 130 nm SOI CMOS line.
Overcoming Intrinsic Resistance of Cancer Cells to CAR T-Cell Killing (2021)

In the past few years, chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment for cancers that failed standard treatments. Such therapies have already been approved in several blood cancers, such as B-cell leukemia and lymphoma. Despite this progress, a significant proportion of patients experience primary or secondary resistance to CAR T-cell therapy. Here, we review the mechanisms by which CAR T cells eliminate their target and how cancer cells may be insensitive to such killing (here referred to as intrinsic resistance). Recent studies suggest that the activation of apoptosis through death receptor signaling is responsible for a major part of CAR T-cell cytotoxicity <i>in vivo</i> Indeed, cancer cells harboring aberrant apoptotic machinery may be insensitive to CAR T-cell killing. This intrinsic resistance of cancer cells to CAR T-cell killing could be responsible for a significant portion of treatment failure. Finally, we discuss strategies that may be envisioned to overcome such resistance to enhance CAR T-cell efficacy.
Optical Nonlinearities In Crystalline Organiz Multiple Quantum Wells (1990)

This paper reports new results arising from the studies of optical interaction in newly demonstrated crystalline organic multiple quantum wells. Recently, these novel materials have been grown by means of organic molecular beam epitaxy ¹ , and their excitonic energy levels have been shown to experience a blue shift as the spatial dimension of the well decreased. The constituent materials were 3,4,9,10 perylenetetracarboxylic dianhydride (PTCDA) as the well and 3,4,7,8 naphthalenetetra­ carboxylic dianhydride (NTCDA) as the barrier.
ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activities (2016)

Sphingolipid synthesis is tightly regulated in eukaryotes. This regulation in plants ensures sufficient sphingolipids to support growth while limiting the accumulation of sphingolipid metabolites that induce programmed cell death. Serine palmitoyltransferase (SPT) catalyzes the first step in sphingolipid biosynthesis and is considered the primary sphingolipid homeostatic regulatory point. In this report, Arabidopsis (Arabidopsis thaliana) putative SPT regulatory proteins, orosomucoid-like proteins AtORM1 and AtORM2, were found to interact physically with Arabidopsis SPT and to suppress SPT activity when coexpressed with Arabidopsis SPT subunits long-chain base1 (LCB1) and LCB2 and the small subunit of SPT in a yeast (Saccharomyces cerevisiae) SPT-deficient mutant. Consistent with a role in SPT suppression, AtORM1 and AtORM2 overexpression lines displayed increased resistance to the programmed cell death-inducing mycotoxin fumonisin B<sub>1</sub>, with an accompanying reduced accumulation of LCBs and C16 fatty acid-containing ceramides relative to wild-type plants. Conversely, RNA interference (RNAi) suppression lines of AtORM1 and AtORM2 displayed increased sensitivity to fumonisin B<sub>1</sub> and an accompanying strong increase in LCBs and C16 fatty acid-containing ceramides relative to wild-type plants. Overexpression lines also were found to have reduced activity of the class I ceramide synthase that uses C16 fatty acid acyl-coenzyme A and dihydroxy LCB substrates but increased activity of class II ceramide synthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB substrates. RNAi suppression lines, in contrast, displayed increased class I ceramide synthase activity but reduced class II ceramide synthase activity. These findings indicate that ORM mediation of SPT activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.
Experimental and Theoretical Study of Deviations from Vegard's Law in the SnxGe1-x System (2003)

First principles density functional theory is used to study the compositional dependence of the structural, elastic, electronic, and bonding properties of newly prepared SnxGe1-x alloys and compounds. The calculated variation of lattice constant a(x) with composition for tin content (% Sn, x < 0.20) exhibits a small and systematic positive deviation of the lattice constants from ideal Vegard behavior, in agreement with our measurements on SnxGe1-x alloys synthesized in this range. Over this range the compressibility also exhibits a concomitant increase relative to the Vegard average. To elucidate this structural behavior, we treat SixGe1-x, GexC1-x, and SixC1-x using the same computational procedure and find the expected negative deviations in a(x) from Vegard's Law behavior in all of these cases. Calculations on molecular analogues, consisting of tetrahedral A(XH3)4 clusters with {A,X} = {Sn,Ge}, {Si,Ge}, {Si,C}, and {Ge,C}, reveal that both the sign and magnitude of the deviations from ideal behavior are also present at the molecular level. The calculated bond lengths in all of these clusters agree well with available molecular structure data for these systems.
IUPAC Critical Evaluation of Thermochemical Properties of Selected Radicals. Part 1. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
U-cache: a cost-effective solution to synonym problem (2002)

This paper proposes a cost-effective solution to the synonym problem. In this proposed solution, a minimal hardware addition guarantees the correctness whereas the software counterpart helps improve the performance. The key to this proposed solution is an addition of a small physically-indexed cache called U-cache. The U-cache maintains the reverse translation information of the cache blocks that belong to un-aligned virtual pages only, where aligned means that the lower bits of the virtual page number match those of the corresponding physical page number. A U-cache, even with only one entry, ensures correct handling of synonyms. A simple software optimization in the form of page alignment, helps improve the performance. Performance evaluation based on ATUM traces shows that a U-cache, with only a few entries, performs almost as well as (in some cases outperforms) a fully-configured hardware-based solution when more than 95% of the pages are aligned.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>