gebhart/patrepeval huggingface dataset:
Data from A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;We sought to evaluate whether combining a humanized antidisialoganglioside mAb (hu14.18K322A) with induction chemotherapy improves early responses and outcomes in children with newly diagnosed high-risk neuroblastoma.&lt;/p&gt;Patients and Methods:&lt;p&gt;We conducted a prospective nonrandomized, single-arm, two-stage, phase II clinical trial. Six courses of induction chemotherapy were coadministered with hu14.18K322A and followed with granulocyte–macrophage colony-stimulating factor (GM-CSF) and low-dose IL2. Consolidation was performed with a busulfan/melphalan preparative regimen. An additional course of hu14.18K322A was administered with parent-derived natural killer cells, when available, during consolidation. Hu14.18K322A, GM-CSF, IL2, and isotretinoin were then administered. Secondary outcomes included reduced tumor volume and semiquantitative &lt;sup&gt;123&lt;/sup&gt;I-metaiodobenzylguanidine scoring [i.e., Curie scores (CS)] at the end of induction.&lt;/p&gt;Results:&lt;p&gt;Forty-two patients received hu14.18K322A and induction chemotherapy. This regimen was well tolerated, with continuous-infusion narcotics adjusted to patient tolerance. Partial responses (PR) or better after the first two chemoimmunotherapy courses occurred in 32 patients [76.2%; 95% confidence interval (CI), 60.6–88.0]. This was accompanied by primary tumor volume reductions (median, –76%; range, –100% to 5%). Of 35 patients with stage IV disease who completed induction, 31 had end-of-induction CSs of 2 or less. No patients experienced progression during induction. Two-year event-free survival (EFS) was 85.7% (95% CI, 70.9–93.3).&lt;/p&gt;Conclusions:&lt;p&gt;Adding hu14.18K322A to induction chemotherapy produced early PR or better in most patients, reduced tumor volumes, improved CSs at the end of induction, and yielded an encouraging 2-year EFS. These results, if validated in a larger study, may change the standard of care for children with high-risk neuroblastoma.&lt;/p&gt;&lt;/div&gt;
On mode-I and mode-II interlaminar crack migration and R-curves in carbon/epoxy laminates with hybrid toughening via core-shell rubber particles and thermoplastic micro-fibre veils (2022)

This study investigates the influence of hybrid toughening—via core-shell rubber (CSR) particles and non-woven thermoplastic veils—on the delamination resistance, crack migration and R-curve behaviour in carbon fibre/epoxy laminates under mode-I and mode-II conditions. Core-shell rubber particles, varying in size from 100 nm to 3 μm, with 0–10 wt% content, are dispersed within the epoxy resin, and thermoplastic micro-fibre veils with polyphenylene sulfide (PPS) fibres, with 5–20 g/m2 areal weight, are introduced at the interlaminar region to achieve hybrid toughening. Carbon fibre/epoxy laminates are manufactured with a two-part resin using vacuum infusion and out-of-autoclave curing. Double cantilever beam (DCB) and four-point end-notch-flexure (4ENF) specimens are used to obtain mode-I and mode-II fracture energies and R-curves. Damage mechanisms and crack paths are characterised using fractography that provide understanding of energy dissipation. The results show that the hybrid toughening significantly improves fracture initiation and propagation energies (i.e. mode I initiation by ∼245% and propagation by ∼275%, and mode-II initiation by ∼64% and propagation ∼215%) by extrinsic and intrinsic toughening mechanisms. Moreover, it is shown that rising R-curves can be achieved with hybrid toughening when compared with falling R-curves obtained with just thermoplastic veil toughening. Fractography revealed that the hybrid toughening constrained the crack predominantly within the veil region, making it harder to grow and absorb more energy.
Comparison of Centralized and Distributed Provisioning of Lightpaths in Optical Networks (2001)

This paper compares centralized and distributed online provisioning approaches in optical networks. In the centralized approach, complete network state is available for path computation. In the distributed approach, summarized information is available for path computation.
Multi-channel Environmental Sound Segmentation utilizing Sound Source Localization and Separation U-Net (2021)

This paper proposes a multi-channel environmental sound segmentation method. Environmental sound segmentation is an integrated method that deals with sound source localization, sound source separation and class identification. When multiple microphones are available, spatial features can be used to improve the separation accuracy of signals from different directions; however, conventional methods have two drawbacks: (a) Since sound source localization and sound source separation using spatial features and class identification using spectral features are trained in the same neural network, it overfits to the relationship between the direction of arrival and the class. (b) Although the permutation invariant training used in speech recognition could be extended, it is not practical for environmental sounds due to the maximum number of speakers limitation. This paper proposes multi-channel environmental sound segmentation method that combines U-Net which simultaneously performs sound source localization and sound source separation, and convolutional neural network which classifies the separated sounds. This method prevents overfitting to the relationship between the direction of arrival and the class. Simulation experiments using the created datasets including 75-class environmental sounds showed that the root mean squared error of the proposed method was lower than that of the conventional method.
Evaluation of frequency stability of terahertz waves generated by Mach-Zehnder-modulator-based flat comb generator (2013)

In order to generate a reference signal used in phase locking of quantum cascade lasers (QCLs) operating in the THz range, we adopted a photonic down-conversion technique. Optical two-tone signals are created by a combination of a Mach-Zehnder-modulator-based flat comb generator (MZ-FCG) and a dispersion-flattened dispersion-decreasing fiber (DF-DDF). THz signals generated from the two-tone signal by using a uni-traveling carrier diode (UTC-PD). We have demonstrated generation of 700 GHz signals, and confirmed that the signal has the C/N ratio of greater than 30 dB and the frequency stability of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> at the averaging time of 1 sec.
Ultrasonic Shear Wave Velocities of MgSiO 3 Perovskite at 8 GPa and 800 K and Lower Mantle Composition (1998)

Ultrasonic interferometric measurements of the shear elastic properties of MgSiO3 perovskite were conducted on three polycrystalline specimens at conditions up to pressures of 8 gigapascals and temperatures of 800 kelvin. The acoustic measurements produced the pressure (P) and temperature (T) derivatives of the shear modulus (G), namely ( partial differentialG/ partial differentialP)T = 1.8 +/- 0.4 and ( partial differentialG/ partial differentialT)P = -2.9 +/- 0.3 x 10(-2) gigapascals per kelvin. Combining these derivatives with the derivatives that were measured for the bulk modulus and thermal expansion of MgSiO3 perovskite provided data that suggest lower mantle compositions between pyrolite and C1 carbonaceous chondrite and a lower mantle potential temperature of 1500 +/- 200 kelvin.
Thermoelectric properties of pnictogen-substituted skutterudites with alkaline-earth fillers using first-principles calculations (2016)

First-principles calculations have been performed to investigate electronic band structures, vibrational characters, and related transport properties of pnictogen-substituted skutterudites filled with alkaline-earth elements (MxCo4A6B6, where M = Ca, Sr, or Ba, A = Ge or Sn, B = Se or Te, and x = 0.5 or 1). Electronic transport properties related to thermoelectricity, including the Seebeck coefficient and the electrical conductivity, are computed by using the Boltzmann transport formalism within the constant-relaxation-time approximation. The results are compared against the corresponding properties of the unfilled pnictogen-substituted ternary skutterudites (CoA1.5B1.5) to identify the effects of filling to estimate the potential for thermoelectric applications. The changes in the ionic character of the interatomic bonding between the Group 14 (A) and Group 16 (B) elements, which was suspected to be a major scattering source in unfilled pnictogen-substituted ternary skutterudites, are probed by analyzing the projected density of states, the charge densities, and the Born effective charges, in an attempt to identify a potential path for improvement of the thermoelectric performance. Our computational results suggest that the analyzed performance of the filled pnictogen-substituted skutterudites should exhibit no significant improvement over that of the corresponding unfilled pnictogen-substituted ternary skutterudites, unless significant reduction in thermal conductivity is achieved by the rattling motion of the filler atoms.
Bayesian Rule Sets for Interpretable Classification (2016)

A Rule Set model consists of a small number of short rules for interpretable classification, where an instance is classified as positive if it satisfies at least one of the rules. The rule set provides reasons for predictions, and also descriptions of a particular class. We present a Bayesian framework for learning Rule Set models, with prior parameters that the user can set to encourage the model to have a desired size and shape in order to conform with a domain-specific definition of interpretability. We use an efficient inference approach for searching for the MAP solution and provide theoretical bounds to reduce computation. We apply Rule Set models to ten UCI data sets and compare the performance with other interpretable and non-interpretable models.
Gas source molecular epitaxy of Ge1−ySny materials and devices using high order Ge4H10 and Ge5H12 hydrides (2021)

This paper describes the fabrication of Ge1−ySny layers with 2%–13% Sn, utilizing a unique method that combines high-order Ge4H10 and Ge5H12 hydrides and gas source molecular epitaxy techniques. The latter operate at very low working pressures of 10−6–10−7 Torr leading to molecular flow regime conditions, promoting layer-by-layer epitaxy of crystalline materials at ultralow-temperatures (250–160 °C) that cannot be achieved by conventional thermal CVD. In both cases, a “direct injection” approach is employed, using the pure vapor of Ge4H10 and Ge5H12 as the source of the Ge flux, which is then reacted on the substrate surface with SnD4 in the absence of gaseous carriers. Ge4H10 reactions were conducted at 215–190 °C, producing 6%–12% Sn samples. These were grown on both conductive, resistive, single-side, and double-side polished Si(100) with n-type Ge1−xSix buffer layers (x = 2%–3%) to explore conditions and substrate formats that facilitate back-side illumination, enabling transparency and enhanced responsivity at 1550 nm in prototype p-i-n devices. Exploratory reactions of Ge5H12 with SnD4 produced Ge1−ySny with 2%–13% Sn at 250–160 °C for the first time. All samples were characterized by XRD, RBS, IR-ellipsometry, AFM, and TEM to investigate the structure, composition, strain state, and morphology. The samples grow partially relaxed (T &amp;gt; 180 °C) and their compressive strains gradually diminish in situ with increasing film thickness (up to 700 nm) without epitaxial breakdown and Sn segregation. Residual strains are further reduced by RTA processing. The experiments described here demonstrate the practicality of our chemistry-based method as an alternative to thermal CVD for the fabrication of high crystal quality samples on larger area wafers for potential applications in IR devices.
Measurements, modelling and electrical simulations of lateral PIN photodiodes in thin film-SOI for high quantum efficiency and high selectivity in the UV range (2004)

The present paper investigates the influence of the SOI structure and in particular the presence of the buried oxide on the Quantum efficiency vs. wavelength characteristics of fully-depleted thin film silicon-on-insulator (SOI) lateral photodetectors by measurements, modelling and simulations.
Thermal cycling fatigue analysis of copper pillar-to-solder joint reliability (2008)

This paper evaluates two novel copper pin-head pillar interconnection structures with solder joints suitable for fine-pitch, low stand-off height interconnection for flip chip technology. Current flip chip interconnection requires underfill encapsulation to meet the requirements in thermal cycling fatigue test. An alternative to underfill encapsulation for improving solder joint reliability is to implement copper pillar-to-solder joint assembly. Such a copper pillar solder joint method is designed to meet the solder joint reliability requirements of 500 cycles suitable for telecom and portable electronic products. Parametric studies were conducted using finite element analysis to investigate the effects of different copper pillar-to-solder joint geometries on the solder fatigue performance.
Abstract 14026: Intermittent Occlusion of the Superior Vena Cava Reduces Estimated Stressed Blood Volume in Patients With Acutely Decompensated Heart Failure (2022)

BACKGROUND: Stressed blood volume (SBV) refers to intravascular volume that produces hydrostatic pressure and contributes to congestion in acutely decompensated heart failure (ADHF). The VENUS HF Early Feasibility Study (EFS) is the first clinical trial testing intermittent occlusion of the superior vena cava (SVC) with the preCARDIA system, a catheter mounted balloon and pump console, to improve decongestion in ADHF. We hypothesized that preCARDIA therapy reduces SBV in ADHF. Methods: In a multicenter, prospective, single-arm exploratory safety and feasibility trial, 32 patients with ADHF were assigned to preCARDIA therapy for 24 hours. Invasive hemodynamics were measured before, immediately after, and for 3 hours after preCARDIA treatment. SBV was estimated (eSBV) using the hemodynamic simulator, Harvi, with heart rate (HR), cardiac output (CO), central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), systolic and diastolic systemic arterial and pulmonary artery (PA) pressures, and left ventricular ejection fraction (LVEF) from 27 enrolled subjects. Results: Mean LVEF was 28±13%. Freedom from device or procedure related major adverse events was observed in 96% (n=26/27) of patients. Compared to pre-treatment values, CVP, PCWP, and PA pressures were significantly reduced, while systemic mean arterial pressures, HR and CO remained unchanged (Table 1). Daily urine output (2.6±1.9 vs 5.2±3.8 L, p=0.0072) and net fluid balance (-1.7±1.4 vs -3.4±2.6 L/24hr, p=0.0098) improved with 24-hours of treatment. Compared to pre-treatment values, eSBV decreased by 22% or -709±551 mL/70kg from baseline to 3 hours after treatment completion (3217±426 vs 2507±694 mL/70kg, p&lt;0.000001). Conclusions: We report for the first time that intermittent SVC occlusion using the preCARDIA system reduced estimated stressed blood volume in patients with ADHF. These results support future studies characterizing the clinical utility of the preCARDIA system.
A Terahertz Leaky-Wave Antenna using a Parallel-Plate Waveguide (2014)

A terahertz leaky-wave antenna was implemented using the TE1 mode of a parallel-plate waveguide with a plate separation of 4 mm. Peak frequencies of leaky wave radiation are shown to be consistent with predicted values.
Phytochemical and antimicrobial screening of the aqueous extract of Cassia arereh Del. stem-bark (2010)

The phytochemical constituents and antimicrobial properties of the aqueous extract of Cassia arereh stem-bark were evaluated. The extract was subjected to qualitative chemical screening of active chemical constituents and disc diffusion method was performed to determine the antimicrobial properties. The results revealed the presence of tannins, phlobatannins, carbohydrate, saponin, flvonoids, terpenes and steroids while anthraquinones, alkaloids and cardiac glycosides were not detected. The extracts (100, 200, 400 and 800 mg/ml) inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Pseudomonas aerogenosa and Enterobacter species. However, Escherichia coli, Klebsiella pneumoniae, Corynebacterium pyogenes and Candida albicans were resistant. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were 50 mg/ml for S. aureus and B. subtilis, and 100 mg/ml for P. aeurogenosa. It was concluded that the aqueous extract of C. arereh stem-bark contained active principles having antibacterial properties and thus support the folkloric use of the plant.
PSC-Watermark: Power Side Channel Based IP Watermarking Using Clock Gates (2023)

With the ever-increasing re-use of intellectual property (IP) cores in modern system-on-chips (SoCs), it is crucial to prevent security risks such as IP piracy and overuse. Considering that IP watermarking is a potential solution to the copyright protection of IP cores, this paper proposes PSC-Watermark as a power side-channel-based IP authentication methodology using clock gates. PSC-Watermark embeds a power signature with very minimal modification to the IP core. It is done by reusing the existing clock gates to modify the dynamic power consumption inside the IP (in an SoC) based on an applied challenge, and it generates a unique power trace that works as a signature of the IP. Our experimental results show that this power signature can be robustly/effectively verified, even with the interferences emanating from the rest of the functional cores in complex SoCs. We evaluate our technique on several benchmarks of varying size (i.e., MIPS, openMSP430, or1200) in the presence of multiple non-watermarked cores operating in parallel and obtain > 90% confidence rate in proving the ownership of each watermarked IP core. Furthermore, the IP cores are watermarked in a subtle and obfuscated way with < 4% overhead, which makes the proposed technique hard to detect, remove or modify.
The Effects of Yttrium Element on Microstructure and Mechanical Properties of Mg-5 mass%Al-3 mass%Ca Based Alloys Fabricated by Gravity Casting and Extrusion Process (2008)

The as-cast microstructure of Mg-5Al-3Ca-xY alloy consists of dendritic α-Mg matrix, (Mg, Al)2Ca eutectic phase and Al2Y intermetallic compounds. These two kind of (Mg, Al)2Ca compounds were observed: coarse irregular-shape structure at grain boundary and fine needle-shape structure in the α-Mg matrix grain. This (Mg, Al)2Ca phase of the extruded alloys was elongated to extrusion direction and size of this phase was refined comparing with that of as-cast alloys because of severe deformation during hot extrusion. Maximum yield and ultimate strength value of extruded alloys was 326 and 331 MPa at Mg-5Al-3Ca-3Y alloy, respectively. From these results, it is conclusively demonstrated that Y additions on Mg-5Al-3Ca alloy have more effect to improve mechanical properties.
Acid Placement: An Effective VES System to Stimulate High-Temperature Carbonate Formations (2012)

Abstract The gelling performance of VES acid systems dramatically weakens at high temperature. Therefore, these fluids are typically limited to placement in relatively low-temperature carbonate formations. This study was conducted to introduce a new VES system that can gel and maintain useful viscosity up to 300F. The new surfactant system is completely compatible with HCl, brine, and even high iron contamination. Rheological studies defined the operational temperature limit where viscosity was sufficient for the new VES system to be used successfully as diversion agent. It was found that initial acid concentration and the degree of acid neutralization were critical parameters affecting the new VES system diversion performance at elevated temperatures. The effects of four corrosion inhibitors were examined. One is recommended for use with this system because it minimizes negative effects on the operational temperature range. Also, it enhances the values of elastic modulus, which enhances the VES system's diversion performance. Coreflood studies using limestone and dolomite cores confirmed that the new VES system increased differential pressure sufficiently to achieve diversion. For limestone cores, the pressure drop increased by a factor of 10 during VES acid injection; for dolomite cores, the pressure drop increased by a factor of 100. The pressure drop changed in a cycling manner, where the crest and trough of each cycle increased with time. Cycling of the pressure drop indicates that the acid was able to change its direction inside the core. Coreflood testing also indicated that there is no need for a breaker, as 18% permeability enhancement was observed with CaCl2 brine flowback. This paper will discuss the results obtained and recommend the conditions under which the new system is most likely to be successful in the field.
The Binding of Alpinia galanga Oil and Its Nanoemulsion to Mammal GABAA Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform (2022)

The anesthetic effect of <i>Alpinia galanga</i> oil (AGO) has been reported. However, knowledge of its pathway in mammals is limited. In the present study, the binding of AGO and its key compounds, methyl eugenol, 1,8-cineole, and 4-allylphenyl acetate, to gamma-aminobutyric acid type A (GABA<sub>A</sub>) receptors in rat cortical membranes, was investigated using a [<sup>3</sup>H]muscimol binding assay and an in silico modeling platform. The results showed that only AGO and methyl eugenol displayed a positive modulation at the highest concentrations, whereas 1,8-cineole and 4-allylphenyl acetate were inactive. The result of AGO correlated well to the amount of methyl eugenol in AGO. Computational docking and dynamics simulations into the GABA<sub>A</sub> receptor complex model (PDB: 6X3T) showed the stable structure of the GABA<sub>A</sub> receptor-methyl eugenol complex with the lowest binding energy of -22.16 kcal/mol. This result shows that the anesthetic activity of AGO and methyl eugenol in mammals is associated with GABA<sub>A</sub> receptor modulation. An oil-in-water nanoemulsion containing 20% w/w AGO (NE-AGO) was formulated. NE-AGO showed a significant increase in specific [<sup>3</sup>H]muscimol binding, to 179% of the control, with an EC<sub>50</sub> of 391 µg/mL. Intracellular studies show that normal human cells are highly tolerant to AGO and the nanoemulsion, indicating that NE-AGO may be useful for human anesthesia.