gebhart/patrepeval huggingface dataset:
An Encoding Scheme for Reporting Sensor Signal Values (2005)

This paper presents a novel encoding scheme as an alternative to Analog amplitude encoding for communicating sensor signals. The scheme has the potential of becoming a non-proprietary industrial standard for communicating sensor information to electronic control modules. Key features of the encoding scheme are the ability to communicate two sensor values using only 3 wires (power, ground and signal) with 12 bit resolution within 1ms. The scheme includes a checksum for error detection and a mechanism for reporting serial data such as low rate sensor information, part numbers or fault codes. Data is communicated to the receiving module by varying the time between discrete (single edge polarity) transitions. The encoding is self-calibrating and does not require an expensive crystal in the sending module (assumed to be a low-cost ASIC) to maintain signal integrity.
Novel Paenibacillus sp. Strains From the Perennial Ryegrass Seed Microbiome Reveal Bioprotectant and Biofertiliser Activity - Differentiating Similar Strains via Genomics and Transcriptomics (2021)

Abstract Paenibacillus species are Gram-positive bacteria that have been isolated from a diverse array of plant species and soils, with some species exhibiting plant growth-promoting (PGP) activities. Here we report a novel Paenibacillus sp. (strains S02 and S25) that was isolated from perennial ryegrass ( Lolium perenne ) seeds. Comparative genomics analyses showed this novel species was closely related to P. polymyxa . Genomic analyses revealed that strains S02 and S25 possess PGP genes associated with biological nitrogen fixation, phosphate solubilisation and assimilation, as well as auxin production and transportation. Moreover, secondary metabolite gene cluster analyses identified 13 clusters that are shared by both strains and three clusters unique to S25. In vitro assays demonstrated strong bioprotection activity against phytopathogens ( Colletotrichum graminicola and Fusarium verticillioides ), particularly for strain S02. A transcriptomics analysis evaluating nitrogen fixation activity showed both strains carry an expressed nif operon, but strain S02 was more active than strain S25 in nitrogen-free media. Another transcriptomics analysis evaluating the interaction of strains with F. verticillioides showed strain S02 had increased expression of core genes of secondary metabolite clusters (fusaricidin, paenilan, tridecaptin and polymyxin) when F. verticillioides was present and absent, compared to S25. Such bioactivities make strain S02 a promising candidate to be developed as a combined biofertiliser/bioprotectant.
Two-Dimensional Power-Line Selection Scheme for Low Subthreshold-Current Multi-Gigabit DRAMs (1993)

Two-dimensional power-line selection scheme for an iterative CMOS circuit block, is proposed to reduce the subthreshold current. In this scheme, a block is divided into sub-blocks of two-dimensional arrangement and selectively energized by two-dimensional power-line selection. The scheme combined with dual word-line structure permits a drastic active current reduction to one sixteenth, from 363 mA to 22 mA, for a 16-Gb DRAM.
Crystallographic and Molecular Mechanics Calculations on the Anti-Tumor Drugs N- [(2-Dimethylamino)Ethyl]-and N-[(2-Dimethyl-Amino)Butyl]-9-Aminoacridine-4-Carboxamides and their Dications: Implications for Models of DNA-Binding (1987)

The molecular structures of the N-(2-dimethylamino)ethyl and N-(2-dimethylamino)butyl derivatives of 9-aminoacridine-4-carboxamide, of current interest as potential anti-cancer agents have been determined by X-ray Crystallography. Both are in the free base form and have an intramolecular-hydrogen bond between N10 of the acridine and the nitrogen atom of the carboxamide substituent. Molecular mechanics calculations have been used to explore the conformational flexibility of this substituent with respect to the chromophore in order to determine the low-energy conformers of both free base and protonated forms. These have revealed flexibility in the system with relatively low energy cost, especially in the physiological condition when the N10 atom is protonated and suggest that a previously published model for the interaction of these compounds with DNA, is energetically feasible. Implications for interactions with DNA have also been examined by computer modelling.
New alginate-chitosan hydrogel beads with anti-inflammatory and anabolic effects on human chondrocytes (2011)

peer reviewed
Synergistic multi-source ambient RF and thermal energy harvester for green IoT applications (2023)

In a future green Internet of Things (IoT) reality, billions of devices of the IoT infrastructure should be self-powered. Harvesting ambient energy to power IoT devices is an attractive solution that can extend battery life or can completely replace batteries. Considering the global applications of IoT, ubiquitous and continuous availability is an important requirement for ambient energy sources. Radio frequency (RF) energy from mobile phone towers and thermal energy from diurnal cycle temperature fluctuations are good candidates. In this study, we present a synergistic multi-source energy harvester (MSEH) comprising an RF energy harvester (RFEH) and a thermal energy harvester (TEH) integrated through a dual-function component, heatsink antenna. Both harvesters collect ambient energy 24 h a day and are not location specific. The TEH, which is in the shape of a box, collects energy using heatsinks on its sidewalls. The same heatsinks are optimized to also serve as receiving antennas of the RFEH, which collects energy from the GSM900, GSM1800, and 3G bands. Due to the synergistic integration, radiation efficiency of the antenna doubled from 40% to 80% which resulted in ∼10% increase in power conversion efficiency of the RFEH. Similarly, the average power of the TEH without heatsinks 120 μW is doubled to 240 μW for TEH with heatsinks. Field tests have shown that the outputs of the TEH and RFEH have increased 4 and 3 times compared to the independent TEH and RFEH respectively. A temperature and humidity sensor based IoT node has been successfully powered through this energy harvesting system. Overall, the MSEH can collect 3680 μWh of energy per day which is sufficient to obtain the sensors data with a time interval of 3.5 s.
Influence of background concentration induced field on the emission rate signatures of an electron trap in zinc oxide Schottky devices (2010)

Various well-known research groups have reported points defects in bulk zinc oxide (ZnO) [ND (intrinsic): 1014–1017 cm−3] naming oxygen vacancy, zinc interstitial, and/or zinc antisite having activation energy in the range of 0.32–0.22 eV below conduction band. The attribution is probably based on activation energy of the level which seems not to be plausible in accordance with Vincent et al., [J. Appl. Phys. 50, 5484 (1979)] who suggested that it was necessary to become vigilant before interpreting the data attained for a carrier trap using capacitance transient measurement of diodes having ND greater than 1015 cm−3. Accordingly the influence of background free-carrier concentration, ND induced field on the emission rate signatures of an electron point defect in ZnO Schottky devices has been investigated by means of deep level transient spectroscopy. A number of theoretical models were tried to correlate with the experimental data to ascertain the mechanism. Consequently Poole–Frenkel model based on Coulomb potential was found consistent. Based on these investigations the electron trap was attributed to Zn-related charged impurity. Qualitative measurements like current-voltage and capacitance-voltage measurements were also performed to support the results.
Down-regulation of Fine Dusts-induced Airway Inflammation by the PDZ motif peptide of ZO-1 (2020)

Abstract BACKGROUND: Although fine airborne particulate matter (PM) has been known to play a role in many human diseases, there is no direct evidence that therapeutic drugs or proteins can diminish PM-induced diseases. Nevertheless, studies examining the negative control mechanisms of PM-induced diseases are critical to develop novel therapeutic medications. RESULTS: We found that CLB2.0, a surrogate for PM, induced production of multiple cytokines that alter airway inflammation. Interestingly, deletion of each PDZ domain in the ZO-1 protein dramatically decreased F-actin formation and increased the expression of genes for pro-inflammatory cytokines. We also found that the consensus PDZ peptide in ZO-1 downregulates the expression of pro-inflammatory cytokine genes and F-actin formation; in contrast, the GG24,25AA mutant PDZ peptide upregulates them. Moreover, CLB2.0-induced F-actin formation in 2D and 3D matrix cultures was significantly inhibited by PDZ peptide, but not by the mutant peptide. Induction of IL-8 secretion by CLB2.0 activates CXCR2 signaling, while increased RGS12 controlled by the PDZ peptide inhibits IL-8/CXCR2 signaling. The consensus PDZ peptide also inhibited CLB2.0-induced inflammatory cell infiltration, pro-inflammatory cytokine gene expression, and TEER in bronchoalveolar lavage (BAL) fluid and AM cells. CONCLUSIONS: Our data indicated that the PDZ domain in ZO-1 is critical for regulation of the CLB2.0-induced inflammatory microenvironment. Therefore, we suggest that the PDZ peptide may be a potential therapeutic candidate during PM-induced respiratory diseases.
Adjuvant Activity of Synthetic Cell‐Wall Peptidoglycan Subunits on Monoazobenzenearsonate‐N‐acetyl‐L‐tyrosine and Bacterial α‐Amylase in Guinea Pigs (1976)

It is well established that Freund's complete adjuvant composed of heat-killed mycobacterial cells and mineral oil is the most potent adjuvant for the induction of cellmediated immunity to soluble antigens Previously, the authors Data accumulated recently suggest that cell walls not only of mycobacteria but also of other bacteria such as Streptococcus, Staphylococcus, Bacillus, Escherichia, Neisseria, Moraxella and Proteus are active as adjuvants for the induction of circulating antibodies and delayed type hypersensitivity in guinea pigs
A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer (2019)

Thus, in one volunteer we show a granuloma forming by peptides combined with an efficient adjuvant in a water-in-oil-emulsion, inducing antigen specific T cells detectable in circulation and at the vaccination site, after one single vaccination only. The ex vivo T cell responses in peripheral blood were detectable for more than one year and could be strongly boosted by a second vaccination. Hence, XS15 is a promising adjuvant candidate for peptide vaccination, in particular for tumor peptide vaccines in a personalized setting.
A vaccine for HIV type 1: The antibody perspective (1997)

Antibodies that bind well to the envelope spikes of immunodeficiency viruses such as HIV type 1 (HIV-1) and simian immunodeficiency virus (SIV) can offer protection or benefit if present at appropriate concentrations before viral exposure. The challenge in antibody-based HIV-1 vaccine design is to elicit such antibodies to the viruses involved in transmission in humans (primary viruses). At least two major obstacles exist. The first is that very little of the envelope spike surface of primary viruses appears accessible for antibody binding (low antigenicity), probably because of oligomerization of the constituent proteins and a high degree of glycosylation of one of the proteins. The second is that the mature oligomer constituting the spikes appears to stimulate only weak antibody responses (low immunogenicity). Viral variation is another possible obstacle that appears to present fewer problems than anticipated. Vaccine design should focus on presentation of an intact mature oligomer, increasing the immunogenicity of the oligomer and learning from the antibodies available that potently neutralize primary viruses.
A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis (2009)

The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the specificity and functions of CD8 T cells, such as the expression of group 1 CD1 proteins that are capable of presenting Mycobacterium tuberculosis lipids antigens and the cytotoxic/bactericidal protein granulysin. Employing a more relevant nonhuman primate model of human tuberculosis, we examined the contribution of BCG- or M. tuberculosis-elicited CD8 T cells to vaccine-induced immunity against tuberculosis. CD8 depletion compromised BCG vaccine-induced immune control of M. tuberculosis replication in the vaccinated rhesus macaques. Depletion of CD8 T cells in BCG-vaccinated rhesus macaques led to a significant decrease in the vaccine-induced immunity against tuberculosis. Consistently, depletion of CD8 T cells in rhesus macaques that had been previously infected with M. tuberculosis and cured by antibiotic therapy also resulted in a loss of anti-tuberculosis immunity upon M. tuberculosis re-infection. The current study demonstrates a major role for CD8 T cells in anti-tuberculosis immunity, and supports the view that CD8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics.
Online Adjustment of Start of Injection and Fuel Rail Pressure Based on Combustion Process Parameters of Diesel Engine (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Most modern diesel engines are equipped with common fuel rail system. The common fuel rail pressure and start of injection are two important fuel path control variables which are needed to be carefully calibrated over all engine operation range. They both have big effects on engine emissions, fuel consumptions and combustion noise performance. Though there are mature techniques such as design of experiment, model based calibration together with optimization method for engine calibration task, the engine test points are still many and the calibration costs are still high. Besides, the outputs of the calibration are look up tables or maps which are used in engine open loop control strategy in engine control system. Open loop control system has no adaptive and disturbance rejection ability. So the initially optimally calibrated look up control tables will gradually become less and less optimal when the engine is aging. Furthermore, if the fuel property or the fuel injection system performance changes, those calibrated look up tables may not fit and may need to be recalibrated.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;A reliable and simple combustion process parameters based two-input-two-output feedback control structure was proposed in this paper to replace the lookup table based start of injection and fuel rail pressure control system. The controlled combustion parameters are combustion phasing and a variable consists of combined information of ignition delay and combustion width. The control strategy is a decentralized control which also can be named as two single loop control system. The references for these two combustion parameters were calculated from two linear algebra equations involved with only two engine variables: speed and load. The constants in the reference algorithm were obtained by a solution to a neural network engine model based optimization problem subjected to a specific engine transient test type. The results of engine speed and torque transient test show that this combustion parameters feedback based start of injection and fuel rail pressure online adjustment system works not only smoothly but reliably and makes engine has improved fuel consumption and exhaust gas emissions performance compared to lookup table control system. By applying this control strategy, enormous calibration work could be reduced and combustion process is closed loop controlled.&lt;/div&gt;&lt;/div&gt;
Identification of Residues of the Caenorhabditis elegans LIN-1 ETS Domain That Are Necessary for DNA Binding and Regulation of Vulval Cell Fates (2004)

LIN-1 is an ETS domain protein. A receptor tyrosine kinase/Ras/mitogen-activated protein kinase signaling pathway regulates LIN-1 in the P6.p cell to induce the primary vulval cell fate during Caenorhabditis elegans development. We identified 23 lin-1 loss-of-function mutations by conducting several genetic screens. We characterized the molecular lesions in these lin-1 alleles and in several previously identified lin-1 alleles. Nine missense mutations and 10 nonsense mutations were identified. All of these lin-1 missense mutations affect highly conserved residues in the ETS domain. These missense mutations can be arranged in an allelic series; the strongest mutations eliminate most or all lin-1 functions, and the weakest mutation partially reduces lin-1 function. An electrophoretic mobility shift assay was used to demonstrate that purified LIN-1 protein has sequence-specific DNA-binding activity that required the core sequence GGAA. LIN-1 mutant proteins containing the missense substitutions had dramatically reduced DNA binding. These experiments identify eight highly conserved residues of the ETS domain that are necessary for DNA binding. The identification of multiple mutations that reduce the function of lin-1 as an inhibitor of the primary vulval cell fate and also reduce DNA binding suggest that DNA binding is essential for LIN-1 function in an animal.
VLSI architecture: past, present, and future (1999)

This paper examines the impact of VLSI technology on the evolution of computer architecture and projects the future of this evolution. We see that over the past 20 years, the increased density of VLSI chips was applied to close the gap between microprocessors and high-end CPUs. Today this gap is fully closed and adding devices to uniprocessors is well beyond the point of diminishing returns. To continue to convert the increasing density of VLSI to computer performance we see little alternative to building multicomputers. We sketch the architecture of a VLSI multicomputer constructed from c. 2009 processor-DRAM chips and outline some of the challenges involved in building such a system. We suggest that the software transition from sequential processors to such fine-grain multicomputers can be eased by using the multicomputer as the memory system of a conventional computer.
A Method for Improving Temperature Dependence of an Optical Fiber Current Sensor (2010)

This paper is described a method for improving temperature dependent properties of an intensity modulation type optical fiber current sensor for AC detection using flint glass fiber Faraday sensing element, which has been researched and developed by us. The sensor has highly advantageous properties such as light weight and flexible in various points of view, however, it also has a drawback that its output value is dependent on the ambient temperature where the sensor is installed. The ratio error in the sensor output value changes in the range of -0.4% to +1.2% corresponding to ambient temperature change of -20°C to +80°C. Its temperature dependent property is caused by the combined temperature dependence of a magnetic garnet crystal used in the sensor system and Faraday sensor fiber. We researched this temperature dependent mechanism and devised a gain adjusting method of the signal processing circuit amplifier to an optimum value to reduce the ratio error of the sensor. We verified that the ratio error was reduced remarkably with our method by experiment. The ratio error value obtained by the experiment was -0.1% to +0.2% in relation to ambient temperature change of -20°C to +80°C. This value met the highest accuracy standard for current transformers of protection relays required in JEC 1201-1PS class.
Benchmarking Adiabatic Quantum Optimization for Complex Network Analysis (2016)

We lay the foundation for a benchmarking methodology for assessing current and future quantum computers. We pose and begin addressing fundamental questions about how to fairly compare computational devices at vastly different stages of technological maturity. We critically evaluate and offer our own contributions to current quantum benchmarking efforts, in particular those involving adiabatic quantum computation and the Adiabatic Quantum Optimizers produced by D-Wave Systems, Inc. We find that the performance of D-Wave's Adiabatic Quantum Optimizers scales roughly on par with classical approaches for some hard combinatorial optimization problems; however, architectural limitations of D-Wave devices present a significant hurdle in evaluating real-world applications. In addition to identifying and isolating such limitations, we develop algorithmic tools for circumventing these limitations on future D-Wave devices, assuming they continue to grow and mature at an exponential rate for the next several years.
Static and dynamic accuracy of vitreoretinal surgeons (2005)

Accuracy in manual manipulation in a simulated microsurgical environment has been studied. Three vitreoretinal microsurgeons completed a series of static and dynamic tasks. Results for overall rms position error, overall maximum position error, and estimated physiological tremor amplitude were calculated. The rms amplitude of the error vector in three dimensions averaged 166 mum in a stationary pointing task, and 2009-4506 mum in the dynamic tasks. The maximum error vector magnitude during the stationary task averaged 408 mum during the stationary tests, and 3531-6788 mum in the dynamic tasks. The rms amplitude of tremor during the stationary task averaged 76-101 mum in the three spatial coordinates, with an average vector magnitude of 156 mum rms.
Efficient Construction of a Physical Map by Fiber-Fish of the CLN5 Region: Refined Assignment and Long-Range Contig Covering the Critical Region on 13q22 (1996)

The variant form of late infantile neuronal ceroid lipofuscinosis (vLINCL, locus definition CLN5) represents a progressive brain disease with autosomal recessive inheritance. We have previously assigned the CLN5 locus to chromosome 13q21.1-q32 between markers D13S160 and D13S162 by linkage analysis in Finnish families. The information on ancient recombination events obtained from linkage disequilibrium provided an efficient tool for further refining the assignment of the CLN5 locus. Isolation of two novel (CA)n markers, COLAC1 and AC224, resulted in a dramatic restriction of the critical DNA region. We utilized the Fiber-FISH technique to orient and order the large DNA clones isolated by STSs and were able to eliminate almost totally the restriction digestion and PFGE step in the construction of the long-range DNA contig. Both linkage disequilibrium data and Fiber-FISH analyses assigned the CLN5 locus to a well-defined 200-kb region. Here we report a complete physical map of about 350 kb covering the critical chromosomal region of CLN5, which will facilitate the final isolation of the CLN5 gene.
Weak Localization and Time Reversal of Ultrasound in a Rotational Flow (2006)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. de Rosny, A. Tourin, A. Derode, P. Roux, and M. Fink, "Weak Localization and Time Reversal of Ultrasound in a Rotational Flow," in Photonic Metamaterials: From Random to Periodic, Technical Dgest (CD) (Optica Publishing Group, 2006), paper ThC6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article