gebhart/patrepeval huggingface dataset:
Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39 (2012)

The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
Dual coupler coupled cavities optical gyroscope with enhanced performance (2018)

In recent years, the development of a reliable, low cost, miniaturized optical gyroscope has been a subject of research and development in the scientific and industrial communities. Since the sensitivity of the optical gyroscopes is reduced with the sensor footprint, multi-ring configurations, such as the coupled resonator optical waveguide (CROW) and the triple ring resonator configuration (TRR), were suggested to increase the sensitivity of the small foot print optical gyroscopes. In this work, a dual coupler coupled cavities configuration is suggested to be used in optical gyroscopes to enhance their performance. The configuration consists of two resonators directly coupled to each other. The passive cavity is a dual coupler ring resonator and is inserted in the main cavity such that the circulating light is fed back to the main cavity by the drop port of the coupled cavity. This leads to a smaller full width half maximum (FWHM) and hence better sensitivity. The passive resonator is studied to find analytical expressions for the output electric field and the effect of rotation on this field. The shot noise-limit sensitivity is calculated and compared to the conventional passive gyroscope in two cases: for a constant source power and for a constant detected power. The effect of propagation loss is also studied. An order of magnitude potential enhancement in the sensitivity is shown for silica-on-silicon technology.
Isoselectivity Distribution of Isospecific Centers in Supported Titanium‐Based Ziegler‐Natta Catalysts (2006)

Abstract Summary: This article describes the quantitative aspects of the isoselectivity distribution of isospecific centers in five supported titanium‐based Ziegler–Natta catalyst systems containing different internal and external organic donors. Highly crystalline poly(propylene) fractions of the polymers (insoluble in o ‐xylene at 95 °C) were analyzed by analytical Tref and gel permeation chromatography (GPC) methods. Separation of the Tref curves into the peaks of sterically uniform components (each represented by the Lorentz function) showed that all these “isotactic” poly(propylene) fractions are nonuniform materials. Each highly crystalline fraction contains several distinct components that differ in stereoregularity. The [ mmmm ] values for different components (which have approximately the same isotacticity in different polymers) range from as high as 0.986–0.993 to much lower values, in the 0.935–0.955 range. The number of Tref components and their relative contents are substantially different for the crystalline fractions of the polymers produced with different catalyst systems; these parameters depend on the nature of the internal and the external electron donors in the catalysts. GPC analysis of the crystalline poly(propylene) fractions showed that each consists of four or five Flory components (the components produced by kinetically uniform active centers) with widely different average molecular weights, from ≈1 × 10 4 to ≈1.3 × 10 6 . In general, the probabilities of chain transfer reactions for different active centers decrease with the increase in their isospecificity. Resolution of the Tref curve of the highly crystalline fraction of poly(propylene) prepared with catalyst system 3. magnified image Resolution of the Tref curve of the highly crystalline fraction of poly(propylene) prepared with catalyst system 3.
Comparison of stationarity regions for wireless channels from 2 GHz to 30 GHz (2017)

Millimeter wave (mmWave) communication works in the frequencies above 6 gigahertz (GHz), with the system bandwidth up to 500 megahertz (MHz) or wider. In this case, the channel situations are dramatically different from the existing wireless channels in Third Generation/Fourth Generation (3G/4G) communication systems, and the stationarity of mmWave channels could be very different from our former knowledge. The focus of this paper is to study the frequency and spatial stationarities of mmWave channels. For better understanding, we compare the stationarity regions between mmWave channels and the channels below 6 GHz. First, the general average power delay profile (APDP) method is introduced as a metric to determine the size of the stationarity regions in time, frequency, and spatial domains. Then, the general APDP method is applied in the data analysis of a channel measurement. We find that the frequency stationarity regions of the channels are much larger in mmWave bands above 6 GHz than those in conventional bands below 6 GHz, while the spatial stationarity regions of the channels are much smaller in mmWave bands above 6 GHz than those in conventional bands below 6 GHz.
Liver findings in patients with Carney complex, germline PRKAR1A pathogenic variants, and link to cardiac myxomas (2020)

This study aimed to evaluate liver involvement in patients with Carney complex (CNC) based on a large cohort and to analyze any germline PRKAR1A genotype-phenotype association of liver disease. The study included 83 patients with CNC, followed between 1995 and 2018 at a tertiary research center. We reviewed liver images, recorded types and number of lesions and analyzed per genotype: all patients were sequenced for the PRKAR1A gene. A total of 29/83 patients (24.0%) had liver radiological findings. Patients with liver lesion had a significantly higher rate of pathogenic variants detected in the PRKAR1A gene (72.4 vs 38.9%, P = 0.005, respectively). Patients with a pathogenic variant detected on germline PRKAR1A analysis had a higher risk for having a liver lesion compared with patients with wild-type (WT) PRKAR1A alleles (21/42 (50.0%) vs 8/41 (19.5%), respectively, P = 0.004). Among patients with liver lesions, those with a nonsense PRKAR1A pathogenic-variant had more liver lesions (7/7) than among those with other pathogenic-variant types (8/22, P = 0.001). In multivariable analysis, detection of liver lesion(s) was associated with an odds ratio of 5.2 for cardiac myxomas (95% CI 1.55-17.49, P = 0.008). In conclusion, patients with CNC, particularly with a PRKAR1A pathogenic variant, have a higher rate of liver lesions. Additionally, liver lesions are associated with a high risk for cardiac myxomas in this population.
Polarimetric dynamic vision sensor p(DVS) principles (2020)

This contribution relates to the activities of the TC-19 on “Imaging Signals and Systems.” In a rapidly changing global economy, experiencing an unparalleled integration of science and technology, the development of efficient imaging systems is of extreme significance. The scope of TC-19 is to exchange and disseminate knowledge as well as bridge multidisciplinary areas leading to the creation of new knowledge and establish global collaborative multidisciplinary opportunities by tightening collaborations among government, industry, academia, and healthcare industry. The Committee explores a variety of computer vision and visualization systems spanning from medical imaging to defense, industry, and consumer electronics. These imaging systems use statistical or sophisticated artificial algorithms and require the integration of several technological and computational disciplines, such as detector physics and phenomenology, calibration, metrology, data acquisition, data analysis, image processing, feature extraction, and classification. Often, coexisting competing design requirements and trade-off introduce significant challenges to the design of imaging technologies. For instance, Autonomous Vehicles (AV)s, Unmanned Aerial Vehicles (UAV)s, Unmanned Underwater Vehicle (UUV)s, microsatellites, nanosatellites, and picosatellites for defense and civilian applications are characteristic examples with trade-off between design requirements for high performance imaging and maintaining low-power consumption, high-data transmission, low storage and memory, and reduced payload. To address these competing design challenges, TC-19 introduced the polarimetric neuromorphic vision principles which blend bioinspired principles such as human cognition with the vision of certain arthropods, and aquatic biological species.
Ku-band 10 W high efficiency HJFET power amplifier (2002)

This paper describes a record power performance of a Ku-band power amplifier fabricated with a one-chip 0.45 /spl mu/m gate GaAs-based heterojunction FET (HJFET). The developed HJFET amplifier with 16.8 mm gate periphery exhibited a 40.1 dBm (10.2 W) output power with 50% power-added efficiency (PAE) and 9.5 dB linear gain at 12 GHz. This is the highest PAE, gain and output power combination achieved by a single FET power amplifier at this frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Abstract 197: Molecular interactions of Globo H ceramide with translin-associated factor X (TRAX) underlie its proangiogenic activities (2019)

Glycosphingolipids (GSLs) are ubiquitous glycolipids in eukaryotic plasma membranes that consist of a polar glycan chain and a hydrophobic sphingosine- containing ceramide tail. Although GSLs display various diversities and functions, the mechanistic details of GSL interactions with membranous or intracellular components are poorly understood. Globo H ceramide (GHCer), a tumor-associated GSL overexpressed in most types of epithelial cancers, is a potential target of cancer immunotherapy. Previously, we showed that GHCer is shed by cancer cells to mediate immune suppression and promote angiogenesis in the tumor microenvironment. At the cellular level, GHCer from cancer cells binds to translin-associated factor (TRAX), with consequent release of PLCB1 from TRAX to trigger Ca2+ mobilization. Herein, we found that Gb5-ceramide (Gb5Cer), the pentasaccharide precursor of GHCer, could not promote angiogenesis nor Ca2+ mobilization. At the molecular level, ELISA and biacore analysis revealed that GHCer binds to TRAX with a distinct dissociation constant of 4.09×10-8 M, while its precursors, galactosyl-, lactosyl-, Gb4-, and Gb5Cer- showed negligible binding to TRAX. Molecular docking and molecular dynamics indicated that the fucose residue of Globo H is an important contributor to a favorable glycan conformation for interaction with TRAX, consistent with the finding that Gb5Cer had no proangiogenic activities. In addition, GHCer competed with recombinant C-terminus region of phospholipase C β1 (PLCB1) for binding to TRAX, thus providing a molecular mechanism for the proangiogenic effect of GHCer on tumor microenvironment. This study provides the first evidence for interaction of TRAX with a non-protein GSL, deciphered distinct regions of TRAX for interacting with glycan and lipid portions of GHCer, and illustrated the crucial contribution of fucose moiety on GHCer for its interaction with TRAX and angiogenic activity.Citation Format: John Yu, Sheng-Hung Wang, Jing-Yan Cheng, Jung-Tung Hung, Chun-Cheng Lin, Fei-Yun Lo, Chien-Wei Lee, Alice L. Yu. Molecular interactions of Globo H ceramide with translin-associated factor X (TRAX) underlie its proangiogenic activities [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 197.
Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins (2005)

The DNMT3A (DNA methyltransferase 3A) and DNMT3B genes encode putative de novo methyltransferases and show complex transcriptional regulation in the presence of three and two different promoters respectively. All promoters of DNMT3A and DNMT3B lack typical TATA sequences adjacent to their transcription start sites and contain several Sp1-binding sites. The importance of these Sp1-binding sites was demonstrated by using a GC-rich DNA-binding protein inhibitor, mithramycin A, i.e. on the basis of decrease in the promoter activities and mRNA expression levels of DNMT3A and DNMT3B. Overexpression of Sp1 and Sp3 up-regulated the promoter activities of these two genes. The physical binding of Sp1 and Sp3 to DNMT3A and DNMT3B promoters was confirmed by a gel shift assay. Interestingly, Sp3 overexpression in HEK-293T cells (human embryonic kidney 293T cells) resulted in 3.3- and 4.0-fold increase in DNMT3A and DNMT3B mRNA expression levels respectively by quantitative reverse transcriptase-PCR, whereas Sp1 overexpression did not. Furthermore, an antisense oligonucleotide to Sp3 significantly decreased the mRNA levels of DNMT3A and DNMT3B. These results indicate the functional importance of Sp proteins, particularly Sp3, in the regulation of DNMT3A and DNMT3B gene expression.
Impact of Geometry on the Performance of Cantilever-Based Piezoelectric Vibration Energy Harvesters (2019)

This paper aims at comparing micromachined cantilever structures with the purpose of providing design guidelines towards high performance energy harvesters such that they provide a good output power, resonant frequency and volume tradeoff, while considering microfabrication process limitations. Increasing the power output of piezoelectric energy harvesters by tapering the beams has been presented as promising solution in the literature. This paper investigates the power output of several geometric variations of cantilever beams, and examines the advantages of balancing the strain distribution throughout the beam. A comparison of the impact of different geometries is presented, and recommendations are given. Namely, eight rectangular and trapezoidal T-shaped designs are fabricated and benchmarked. Their resonant frequencies and power outputs are compared for the same available area (1800 μm× 800 μm). Measurements show that the trapezoidal designs can have a higher output power depending on the beam length to mass length ratio, in comparison to the rectangular T-designs that have lower frequencies. Resonant frequencies ranging from 2.9 to 7.2 kHz and power outputs ranging from 2.2 to 7.1 nW are reported.
Principles of Neurocomputing for Science and Engineering (2000)

From the Publisher:
This exciting new text covers artificial neural networks,but more specifically,neurocomputing. Neurocomputing is concerned with processing information,which involves a learning process within an artificial neural network architecture. This neural architecture responds to inputs according to a defined learning rule and then the trained network can be used to perform certain tasks depending on the application. Neurocomputing can play an important role in solving certain problems such as pattern recognition,optimization,event classification,control and identification of nonlinear systems,and statistical analysis. 
Principles of Neurocomputing for Science and Engineering, unlike other neural networks texts,is written specifically for scientists and engineers who want to apply neural networks to solve complex problems. For each neurocomputing concept,a solid mathematical foundation is presented along with illustrative examples to accompany that particular architecture and associated training algorithm. 
The book is primarily intended for graduate-level neural networks courses,but in some instances may be used at the undergraduate level. The book includes many detailed examples and an extensive set of end-of-chapter problems.
Prediction of Postprandial Glycemic Exposure (2006)

Isolated measures of fasting or 2-h glucose concentrations alone or in combination with more complex measures of body composition and function are poor predictors of postprandial glycemic exposure or peak glucose concentration. This may explain, at least in part, the weak and at times inconsistent relationship between these parameters and cardiovascular risk.
DeepThin: A Self-Compressing Library for Deep Neural Networks (2018)

As the industry deploys increasingly large and complex neural networks to mobile devices, more pressure is put on the memory and compute resources of those devices. Deep compression, or compression of deep neural network weight matrices, is a technique to stretch resources for such scenarios. Existing compression methods cannot effectively compress models smaller than 1-2% of their original size. We develop a new compression technique, DeepThin, building on existing research in the area of low rank factorization. We identify and break artificial constraints imposed by low rank approximations by combining rank factorization with a reshaping process that adds nonlinearity to the approximation function. We deploy DeepThin as a plug-gable library integrated with TensorFlow that enables users to seamlessly compress models at different granularities. We evaluate DeepThin on two state-of-the-art acoustic models, TFKaldi and DeepSpeech, comparing it to previous compression work (Pruning, HashNet, and Rank Factorization), empirical limit study approaches, and hand-tuned models. For TFKaldi, our DeepThin networks show better word error rates (WER) than competing methods at practically all tested compression rates, achieving an average of 60% relative improvement over rank factorization, 57% over pruning, 23% over hand-tuned same-size networks, and 6% over the computationally expensive HashedNets. For DeepSpeech, DeepThin-compressed networks achieve better test loss than all other compression methods, reaching a 28% better result than rank factorization, 27% better than pruning, 20% better than hand-tuned same-size networks, and 12% better than HashedNets. DeepThin also provide inference performance benefits ranging from 2X to 14X speedups, depending on the compression ratio and platform cache sizes.
Human Segmentation with Dynamic LiDAR Data (2021)

Consecutive LiDAR scans compose dynamic 3D sequences, which contain more abundant information than a single frame. Similar to the development history of image and video perception, dynamic 3D sequence perception starts to come into sight after inspiring research on static 3D data perception. This work proposes a spatio-temporal neural network for human segmentation with the dynamic LiDAR point clouds. It takes a sequence of depth images as input. It has a two-branch structure, i.e., the spatial segmentation branch and the temporal velocity estimation branch. The velocity estimation branch is designed to capture motion cues from the input sequence and then propagates them to the other branch. So that the segmentation branch segments humans according to both spatial and temporal features. These two branches are jointly learned on a generated dynamic point cloud dataset for human recognition. Our works fill in the blank of dynamic point cloud perception with the spherical representation of point cloud and achieves high accuracy. The experiments indicate that the introduction of temporal feature benefits the segmentation of dynamic point cloud.
Influence of androgen receptor repeat polymorphisms on personality traits in men. (2009)

Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.
Ultra-Wideband Cavity-Backed Four-Arm Sinuous Antenna with Low Height and Uniform Gain Characteristics (2021)

In this study, an ultra-wideband cavity-backed four-arm sinuous antenna with low height and wide gain bandwidth is proposed. To reduce the antenna height, a feeding structure is applied with a coaxial bundle and two-port balun. In addition, a multi-layer radio absorber and metallic cavity are applied to obtain certain characteristics, such as a unidirectional radiation pattern, low profile, and stable reflection coefficient. Additionally, a radiator with low input impedance is applied for a wide gain bandwidth. The proposed antenna operates at 0.4~6.0 GHz and has a relatively low height and large gain bandwidth compared to the performance of previously studied antennas.
Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51 (2010)

Our results establish Rad51 and/or Bax as potential candidates that can be targeted for development of individualized chemotherapeutic interventions that are effective, but minimal in toxicity. The use of Rad51 and Bax modulating compounds could offer women the opportunity to maintain fully functional germ cells despite cancer treatments or aging.
Self-induced transparency in a dispersive and nonlinear Kerr host medium (1991)

A steady-state solution that describes pulse propagation in inhomogeneously broadening two-level atoms embedded in a dispersive and nonlinear Kerr lossless host medium has been found. The solution is of an unchirped hyperbolic-secant form with a linear spatial phase delay. The features of the solution are (i) the group velocity, the amplitude, and the width of the pulse are uniquely determined for given parameters of the medium and the carrier frequency; (ii) the group velocity is independent of the density of the resonant atoms; and (iii) the solution can exist in the positive dispersion region.
Population Modeling of Selexipag Pharmacokinetics and Clinical Response Parameters in Patients With Pulmonary Arterial Hypertension (2017)

Selexipag (Uptravi) is an oral selective IP prostacyclin receptor agonist approved for the treatment of pulmonary arterial hypertension (PAH). The pivotal GRIPHON study was the largest clinical study ever conducted in PAH patients, providing long-term data from 1,156 patients. PAH comedication did not affect exposure to selexipag, while exposure to its active metabolite ACT-333679 was reduced by 30% when taken in combination, clinically not relevant in the context of individual dose up-titration. Using log-linear regression models linking model-predicted steady-state exposure to pharmacodynamics (PD), exposure to selexipag and ACT-333679 showed some statistically significant, albeit not clinically relevant, effects on exercise capacity, laboratory values, and the occurrence of prostacyclin-related adverse events, but not on vital signs or adverse events denoting hemorrhage. Using suitable modeling techniques, the GRIPHON study yielded clinically relevant data with limited burden of pharmacokinetics (PK) blood sampling, demonstrating that PK/PD modeling enables firm conclusions even with sparse PK and PD sampling.
O→C Rearrangements: A Powerful Strategy for the Synthesis of Functionalized Carbocycles (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simultaneous administration of pure antiandrogens, a combination necessary for the use of luteinizing hormone-releasing hormone agonists in the treatment of prostate cancer. (1984)

Although castration levels of serum androgens are consistently achieved after 2-3 weeks of treatment with luteinizing hormone-releasing hormone (LHRH) agonists, the administration of these peptides alone in adult men is always accompanied by a transient increase in plasma testosterone and dihydrotestosterone levels, which lasts for 5-15 days at the beginning of treatment and is accompanied by disease flare-up in some cases, thus seriously limiting the acceptability of this otherwise efficient and well-tolerated treatment. The present data show that the simultaneous administration of a pure antiandrogen neutralizes the influence of the transient increase in serum androgens on prostate cancer, as indicated by the 60% decrease in serum prostatic acid phosphatase observed within 5 days of combined treatment with an LHRH agonist and a pure antiandrogen. The addition of a pure antiandrogen thus makes fully acceptable the use of LHRH agonists as an advantageous substitute for surgical castration and estrogens in the treatment of prostate cancer.