gebhart/patrepeval huggingface dataset:
Mechanical Properties of Acrylate Networks Formed by Visible Laser-Induced Polymerization. 2. Control of the Mechanical Properties (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanical Properties of Acrylate Networks Formed by Visible Laser-Induced Polymerization. 2. Control of the Mechanical PropertiesA. Torres-Filho and D. C. NeckersCite this: Chem. Mater. 1995, 7, 4, 744–753Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/cm00052a021https://doi.org/10.1021/cm00052a021research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data from Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics (2023)

&lt;div&gt;Abstract&lt;p&gt;Soluble ligands are important targets for therapy of cancers and other diseases. Therapeutic monoclonal antibodies (mAb) against such ligands block their interactions with corresponding receptors but do not enhance their removal from the circulation and can increase their half-lives because of the long half-lives of the antibodies. We have hypothesized that mAbs targeting two or more nonoverlapping epitopes on the same ligand could form oligomeric antibody–ligand complexes that can bind to cells expressing Fc gamma receptors (FcγRs) with high avidity leading to their fast and irreversible removal from the circulation. Insulin-like growth factor II (IGF-II) is an example of such ligands and an important target for human cancer therapy. We identified two mAbs, m610.27 and m630.3, which bound to nonoverlapping epitopes on IGF-II with nanomolar affinity, and generated a bispecific antibody, m660. m660 inhibited the interaction of human IGF-II (hIGF-II) with the human breast cancer cell line MCF-7, hIGF-II–mediated IGF receptor type I and insulin receptor phosphorylation, and cell growth. In the presence of hIGF-II, large complexes of m660 were formed that bound to FcγRII-expressing BJAB cells much more efficiently than the monospecific antibody–hIGF-II complexes and were presumably phagocytosed by phorbol 12-myristate 13-acetate–stimulated macrophage-like U937 cells. A mixture of m610.27 and m630.3 exhibited similar properties. To our knowledge, these mAbs are the first reported to target nonoverlapping epitopes on a cancer-related ligand and could represent a novel class of candidate therapeutics against cancers. This approach could also be used to irreversibly eliminate other disease-related soluble ligands. &lt;i&gt;Mol Cancer Ther; 11(7); 1400–10. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Light‐Fueled Climbing of Monolithic Torsional Soft Robots via Molecular Engineering (2021)

Azobenzene‐functionalized liquid crystalline polymer networks (azo‐LCNs) are promising candidates for light‐fueled contactless manipulation of miniaturized soft robots through embedding photoactive molecular switches into alignment‐programmable LCNs. In particular, the 3D helical geometry of azo‐LCNs is reported to achieve rapid photomotility by introducing rolling resistance. However, the maximum height of the obstacle that soft robot can overcome is limited by the helix diameter and the stress–strain responsivity. Herein, the helical diameter per unit length and photogenerated stress through molecular engineering of photoactive molecular switches are maximized. The carbon number of aliphatic spacers in the photoactive molecular switches is varied from two to eight to systematically investigate the structure–property–performance relations by studying the molecular geometry, physical properties of polymers, and photomotility of polymers. Furthermore, a finite‐element analysis simulation is presented to understand the rolling locomotion of helical torsional soft robots. Through molecular engineering, the helix diameter per unit length of 0.2 mg soft robots is maximized, demonstrating high Young's modulus (≈2 GPa) and photogenerated stress (&gt;1 MPa), as well as large velocity per body length, compared with the previously reported soft robots. Finally, the molecularly engineered soft robots successfully climb stairs, which is a key task in robotic systems.
Fluorine effects on silicidation of BF/sub 2//sup +/-implanted narrow poly lines (2003)

The use of BF/sub 2//sup +/ for p/sup +/ source/drain implant has resulted in void formation in TiSi/sub 2/ films on p/sup +/ poly and diffusion regions due to the interaction between fluorine outdiffusion and Ti silicidation. When using B/sup +/ instead of BF/sub 2//sup +/, no voids were observed. Deposition of a TEOS layer (150 /spl Aring/) as a fluorine gettering source before p/sup +/ activation anneal reduces the number of voids formed considerably. The sheet resistance of the silicided p/sup +/ narrow poly has improved substantially with the reduction or elimination of the fluorine-induced effects.
Effect of impact pulse parameters on consistency of board level drop test and dynamic responses (2005)

Board level solder joint reliability performance during drop test is a critical concern to semiconductor and electronic product manufacturers. JEDEC standard for board level drop test of handheld electronic products addresses requirements from test board design, material, construction and assembly of test board, component location, tester setup, and reporting format in details. However, the effects of peak acceleration, duration, and shape of impact pulse are not emphasized there, which should be key variables that affect the solder joint reliability during drop impact. In this paper, effect of impact pulse is investigated by both theoretical analysis and numerical modeling. The input acceleration (input-G) method established is a convenient tool to verify the conclusions made from theoretical analysis. The results show that not only the peak acceleration and pulse duration, but also the pulse shape and area under impact pulse significantly affect the solder joint performance during drop test. The variations of peak acceleration pulse duration, and pulse shape usually induce significant scattering of drop test results due to different testers, or operators although the impact pulses are all within JEDEC test specification. Therefore, the specification of impact pulse should be tightened. For this sake, electronic product manufacturers should have some strategy to minimize such effects for component qualification or selection. The stress levels under different test conditions are also examined. Numerical modeling makes it possible to convert the drop test result from one test condition to another test conditions without performing additional drop tests, and thus saving time and cost. Acceleration factors for different test conditions can be obtained based on good correlation of drop impact life between experiment and modeling.
Solution and Solid State Synthesis of the Discrete Polyiodide I73– under Modular Cation Templation (2012)

Discrete I73¯ polyiodide is obtained in pure form through solution and solid-state processes thanks to templation by a triammonium cation which elicits the selective formation of the size matching supramolecular anion.
Enzymic oxidation of cholesterol in reverse micelles (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleEnzymic oxidation of cholesterol in reverse micellesAnagha Gupte, R. Nagarajan, and Arun KilaraCite this: Ind. Eng. Chem. Res. 1995, 34, 8, 2910–2922Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://doi.org/10.1021/ie00047a045Request reuse permissionsArticle Views173Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Laterally oxidized long wavelength CW vertical- cavity lasers (1996)

Vertical-cavity lasers (VCLs) operating at 1.3 and 1.55 µm wavelengths are potentially low cost sources for optical communications.
Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques (2017)

Myeloid derived suppressor cells (MDSCs), which suppress anti-tumor or anti-viral immune responses, are expanded in the peripheral blood and tissues of patients/animals with cancer or viral infectious diseases. We here show that in chronic SIV infection of Indian rhesus macaques, the frequency of MDSCs in the bone marrow (BM) was paradoxically and unexpectedly decreased, but increased in peripheral blood. Reduction of BM MDSCs was found in both CD14+MDSC and Lin-CD15+MDSC subsets. The reduction of MDSCs correlated with high plasma viral loads and low CD4+ T cell counts, suggesting that depletion of BM MDSCs was associated with SIV/AIDS disease progression. Of note, in SHIVSF162P4-infected macaques, which naturally control viral replication within a few months of infection, the frequency of MDSCs in the bone marrow was unchanged. To investigate the mechanisms by which BM MDSCs were reduced during chronic SIV infection, we tested several hypotheses: depletion due to viral infection, alterations in MDSC trafficking, and/or poor MDSC replenishment. We found that the possible mobilization of MDSCs from BM to peripheral tissues and the slow self-replenishment of MDSCs in the BM, along with the viral infection-induced depletion, all contribute to the observed BM MDSC reduction. We first demonstrate MDSC SIV infection in vivo. Correlation between BM CD14+MDSC reduction and CD8+ T cell activation in tissues is consistent with decreased immune suppression by MDSCs. Thus, depletion of BM MDSCs may contribute to the pathologic immune activation during chronic SIV infection and by extension HIV infection.
Towards the Machine Comprehension of Text: An Essay (2013)

The Machine Comprehension of Text (MCT)1 has been a central goal of Artificial Intelligence for over fifty years. How does one even define “machine comprehension”? Researchers often invoke the Tur-
Bit-Operation-Based Seed Augmentation for LFSR Reseeding with High Defect Coverage (2009)

We present a design-for-testability (DFT) technique for increasing the effectiveness of LFSR reseeding for unmodeled defects. The proposed method relies on seed selection using the output-deviations metric and the on-chip augmentation of seeds using simple bit-operations. Simulation results for benchmark circuits show that compared to LFSR reseeding using output deviations alone, the proposed method provides higher coverage for transition-delay and bridging faults, and steeper coverage ramp-up for these faults for the same number of seeds. For the same pattern count (and much fewer seeds), the proposed method provides comparable unmodeled defect coverage. In all cases, complete coverage of modeled stuck-at faults is obtained. We therefore conclude that high test quality can be obtained with the proposed LFSR reseeding method using a smaller number of seeds.
A Flexible Wideband Millimeter-Wave Channel Sounder with Local Area and\n NLOS to LOS Transition Measurements (2017)

This paper presents a millimeter-wave (mmWave) wideband sliding correlator\nchannel sounder with flexibility to operate at various transmission rates. The\nchannel sounder can transmit and receive up to 1 GHz of RF null-to-null\nbandwidth while measuring a 2 nanosecond multipath time resolution. The system\narchitecture takes advantage of field-programmable gate arrays (FPGAs),\nhigh-speed digital-to-analog converters (DACs), and low phase noise Rubidium\n(Rb) references for synchronization. Using steerable narrowbeam antennas, the\nsystem can measure up to 185 dB of path loss. The channel sounder is used to\nmeasure the directional and omnidirectional received power as a receiver\ntransitions from line-of-sight to non-line-of-sight conditions down an urban\ncanyon. A 25 dB drop in omnidirectional received power was observed as the\nreceiver transitioned from line-of-sight (LOS) conditions to deeply shadowed\nnon-LOS (NLOS) conditions. The channel sounder was also used to study signal\nvariation and spatial consistency for a local set of receiver locations\narranged in a cluster spanning a 5 m x 10 m local area, where the\nomnidirectional received power in LOS and NLOS environments is found to be\nrelatively stable with standard deviations of received power of 2.2 dB and 4.3\ndB, respectively. This work shows that when implementing beamforming at the\ntransmitter at mmWave, the omnidirectional received power over a local area has\nlittle fluctuation among receiver locations separated by a few to several\nmeters.\n
Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow (1999)

Under the physiological shear condition, cultured colon cancer cells bound to laminin (LM), but not to fibronectin or vitronectin. Most of the tethered cells did not roll, but arrested immediately and spread within 10-30 min on LM under the continuous presence of shear flow. The tethering of Colo201 was partially inhibited by monoclonal antibodies (mAbs) to alpha6 integrin and a combination of mAbs to beta1 and beta4 integrins, but not by mAb to 67KD laminin receptor. Some Colo201 cells still tethered at 4 degrees C. This suggests that alpha6beta1 and alpha6beta4 integrins participate in Colo201 tethering on LM, although other non-integrin molecules play roles. In contrast, the spread of Colo201 was effectively inhibited by the mAbs to integrin alpha2, alpha6 and beta1 chains. The effect of anti-alpha2 plus anti-alpha6 mAbs was almost equal to anti-beta1, suggesting that Colo201 cells mainly use alpha2beta1 and alpha6beta1 integrins for spreading on LM. When the cells were perfused on subconfluent endothelial cells (HUVEC) cultured on LM, they did not tether on HUVEC but did on coated LM exposed at intercellular gap area. Immunohistochemistry revealed that LM abundantly existed in the cytosol of human portal and hepatic vein endothelial cells. These data suggest that LM can mediate from tethering to spreading of colon cancer cells under the blood flow and plays an essential role in haematogeneous metastasis.
Developing Multi Stimuli‐Responsive Core/Shell Microcapsules to Control the Release of Volatile Compounds (2018)

Abstract Encapsulation of 2‐oxoacetates into poly(urea‐urethane) core/shell microcapsules allows the light‐induced controlled release of volatile compounds such as fragrances, plant volatiles, pheromones, or other semiochemicals. On exposure to UVA light, 2‐oxoacetates decompose to form a carbonyl compound together with CO 2 or CO, which can build overpressure inside the capsules that expands and/or cleaves the capsule wall to release its content. The influence of the structure and ratio of the polyisocyanates and diamines used for interfacial polymerization, as well as the composition of the capsule wall and the oil phase, are investigated by dynamic headspace analysis of the released volatile compounds to optimize the performance of the delivery system. The combination of a light‐induced release with the mechanical cleavage of the capsule gives access to multi stimuli‐responsive systems that selectively respond to the different triggers applied. Furthermore, the concept outlined in the present work is generally applicable to other photolabile precursors that generate a gas inside the capsules and thus release co‐encapsulated active molecules as a direct response to light.
What Happened to the Concept of the Physician–Scientist? (2012)

Academic Medicine serves as an international forum for the exchange of ideas and information about policy, issues, and research concerning academic medicine, including strengthening the quality of medical education and training, enhancing the search for biomedical knowledge, advancing research in health services, and integrating education and research into the provision of effective health care.
Transcriptional repressor CopR: Structure model-based localization of the deoxyribonucleic acid binding motif (2000)

The plasmid pIP501 encoded transcriptional repressor CopR is one of the two regulators of plasmid copy number. CopR binds as a dimer to a nearly palindromic operator with the consensus sequence 5`-CGTG. Intermediate sequence searches revealed a significant structural relationship between CopR and the bacteriophage P22 c2 and the 434 c1 repressors. In this report we describe the experimental verification of a CopR homology model, which is based on a fairly low-sequence identity of 13.8 % to P22 c2 repressor. A model for the complex of CopR with the deoxyribonucleic acid (DNA) target was built on the basis of experimental footprinting data, the above-mentioned CopR homology model, and the crystal structure of the 434 c1 repressor-DNA complex. Site-directed mutagenesis was used to test the function of amino acids involved in sequence and nonsequence-specific DNA recognition and amino acids important for correct protein folding. CD measurements were performed to detect structural changes caused by the mutations. Exchanges of residues responsible for sequence-specific DNA recognition reduced binding to a nonspecific level. Mutations of amino acids involved in nonspecific DNA binding lead to decreased binding affinity while maintaining selectivity. Substitution of amino acids necessary for proper folding caused dramatic structural changes. The experimental data support the model of CopR as a helix-turn-helix protein belonging to the λ repressor superfamily. Proteins 2000;38:393–406. © 2000 Wiley-Liss, Inc.
RPE Cells Modulate Subretinal Neovascularization, but Do Not Cause Regression in Mice with Sustained Expression of VEGF (2003)

Despite persistent high expression of VEGF and its receptors, NV stopped growing and reached a plateau in older V-6 mice. RPE cells modulated the NV by surrounding it and reestablishing the blood-retinal barrier, but did not cause regression, although some vessels in chronic lesions were not perfused. These data do not support the conclusion of several previously reported studies, that RPE cells cause regression of CNV.
High-frequency Properties of CoZrNb/Fe-C Multilayer Films (2003)

High permeability of -500 up to the GHz frequency range was observed in a CoZrNb/Fe-C multilayer film deposited by using a facing-target sputtering apparatus at room temperature. It was found that the Fe-C layer played a key role in increasing the saturation magnetization and the anisotropy field of the multilayer film sufficiently to raise the ferromagnetic resonance frequency beyond 2.0GHz. The multilayer film was soft magnetic when the thickness of the Fe-C layer was 5-50 nm. The Fe-C layer exhibited a columnar growth feature, and the aspect ratio of the column increased with increasing the Fe-C layer thickness. Magnetic anisotropy perpendicular to the film plane appeared in multilayer films with Fe-C layer thicknesses of -80nm and above.
Magnetic ground state of nanosized β-Fe2O3and its remarkable electronic features (2015)

In this study, we report on structural, magnetic, and electric features of β-Fe<sub>2</sub>O<sub>3</sub>identifying its magnetic ground state and its potentiality in photoelectrochemical applications.
Modeling long-term dependencies and short-term correlations in patient journey data with temporal attention networks for health prediction (2022)

Building models for health prediction based on Electronic Health Records (EHR) has become an active research area. EHR patient journey data consists of patient time-ordered clinical events/visits from patients. Most existing studies focus on modeling long-term dependencies between visits, without explicitly taking short-term correlations between consecutive visits into account, where irregular time intervals, incorporated as auxiliary information, are fed into health prediction models to capture latent progressive patterns of patient journeys. We present a novel deep neural network with four modules to take into account the contributions of various variables for health prediction: i) the Stacked Attention module strengthens the deep semantics in clinical events within each patient journey and generates visit embeddings, ii) the Short-Term Temporal Attention module models short-term correlations between consecutive visit embeddings while capturing the impact of time intervals within those visit embeddings, iii) the Long-Term Temporal Attention module models long-term dependencies between visit embeddings while capturing the impact of time intervals within those visit embeddings, iv) and finally, the Coupled Attention module adaptively aggregates the outputs of Short-Term Temporal Attention and Long-Term Temporal Attention modules to make health predictions. Experimental results on MIMIC-III demonstrate superior predictive accuracy of our model compared to existing state-of-the-art methods, as well as the interpretability and robustness of this approach. Furthermore, we found that modeling short-term correlations contributes to local priors generation, leading to improved predictive modeling of patient journeys.
Rotavirus prevalence and relationships with climatological factors in gabon, africa (1985)

A one-year study of rotavirus prevalence was carried out using electron microscopy in Gabon, equatorial Africa. One hundred fifty-six nonhospitalized diarrheic children up to 10 years of age and 115 age-matched controls were investigated together with diarrheic adults and children over 10 years of age. Rotaviruses were observed only in diarrheic children under 10 years of age (10.2%). Rotaviruses were more prevalent in the dry-season months (19.2% versus 1.3%, P less than .001). Rotaviruses were the most commonly found among all the viral, bacterial, and parasitic agents we detected, with the exception of the coronaviruslike particles, which are the subject of another paper [Sitbon, 1985].