gebhart/patrepeval huggingface dataset:
Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri (2009)

Diketopiperazines (DKPs) are a well-known class of heterocycles that have emerged as promising biologically active scaffolds. Solid-phase organic synthesis has become an important tool in the combinatorial exploration of these privileged structures, expediting the synthesis and, often, the discovery of active compounds. We recently identified several DKPs that are capable of inhibiting the luminescence response of the bacterial symbiont Vibrio fischeri, and we sought to further test the scope of this biological activity. Herein, we report the synthesis of DKP macroarrays using a SPOT-synthesis approach based on an Ugi/DeBoc/Cyclize strategy. Neither a spacer nor a linker was required for macroarray construction on cellulose support, and the cyclative cleavage produced high purity DKPs in good yields. Using this protocol, we prepared a library of 400 DKPs on cellulose support and evaluated its members as luminescence inhibitors in V. fischeri. We found six DKPs capable of inhibiting luminescence by at least 80% at 500 muM. Collectively, this work serves to further highlight the utility of the small molecule macroarray platform for the synthesis and evaluation of focused libraries.
The role of NFATc1 in tumor T cell responses to lung cancer (101.6) (2010)

Abstract Nuclear factor of activated T cells (NFAT) proteins represent a Ca2+/calcineurin- regulated family of transcription factors that control T cell differentiation processes. Specifically NFATc1 and NFATc2 are highly expressed in peripheral T cells and activate the IL-2 and IL-4 promoters, suggesting that the Ca2+-regulated calcineurin/NFAT cascade controls alternative pathways of T cell activation and peripheral tolerance. NFATc1 is strongly activated upon antigen dependent T cell receptor engagement and induces genes that are involved in T cell effector function. In this study we describe that patients affected by lung Adenocarcinoma showed increased NFATc1 mRNA and protein levels in their lungs suggesting an involvement of NFATc1 on lung tumor development. To define the role of NFATc1 on lung cancer we start to analyze NFATc1 deficient mice in a murine model of lung Melanoma. Since NFATc1-deficient mice die at the embryonic stage, we bred conditional NFATc1 mice with CD4-Cre mice to gain insight into the role of NFATc1 in tumor T cell responses. Our preliminary results in this model showed a reduced tumor area in NFATc1-deficient mice compared to wild type mice. We also demonstrated here, that naïve T cells, isolated from NFATc1-deficient mice, produced less IL-17 under Th17- skewing conditions compared to those isolated from wild-type mice indicating a pathogenetic effect mediated by NFATc1 via IL-17 in lung tumor that must be further investigated.
Future Internet Bandwidth Trends: An Investigation on Current and Future Disruptive Technologies (2013)

Executive Summary New technologies sometimes result in disruptive changes to the existing infrastructure. Without adequate foresight, industry, academia, and government can be caught flat-footed. In this work, we focus on the trends surrounding home Internet bandwidth — the bandwidth required by end user applications at home. As building and managing last mile network infrastructure incurs substantial cost, the foresight of such trends is necessary to plan upgrades. Using a bottom-up approach, we look at four potentially disruptive technologies, including millimeter wave wireless (mm-wave), the Internet of Things (IoT), Fog Computing, and Software Defined Networking (SDN). We examine use cases proposed by academia and industry, delve into the bandwidth requirements for proposed applications, and use this data to forecast future traffic demands for typical home users. Our projections show that bandwidth changes at end user devices will most likely be driven by two of the above technologies: millimeter wave wireless and Fog Computing. These technologies not only change the peak bandwidth, but also have noticeable secondary effects on bandwidth such as increasing upload bandwidth use, improving flash crowd tolerance, and increasing off-peak demand. While IoT and SDN are important, innovative technologies, they will not drastically alter the bandwidth usage patterns of ordinary users at home. We hope that the data and recommendations from this study can help business leaders and policy makers get an early jump on emerging technologies before they begin to shape the economy and society. ∗This paper was written with financial support from the Time Warner Cable Research Program on Digital Communications, 2013. The views expressed are those of the author(s) and not necessarily those of Time Warner Cable or the Time Warner Cable Research Program on Digital Communications.
Dithienogermole As a Fused Electron Donor in Bulk Heterojunction Solar Cells (2011)

We report the synthesis and bulk heterojunction photovoltaic performance of the first dithienogermole (DTG)-containing conjugated polymer. Stille polycondensation of a distannyl-DTG derivative with 1,3-dibromo-N-octyl-thienopyrrolodione (TPD) results in an alternating copolymer which displays light absorption extending to 735 nm, and a higher HOMO level than the analogous copolymer containing the commonly utilized dithienosilole (DTS) heterocycle. When polyDTG-TPD:PC(70)BM blends are utilized in inverted bulk heterojunction solar cells, the cells display average power conversion efficiencies of 7.3%, compared to 6.6% for the DTS-containing cells prepared in parallel under identical conditions. The performance enhancement is a result of a higher short-circuit current and fill factor in the DTG-containing cells, which comes at the cost of a slightly lower open circuit voltage than for the DTS-based cells.
Biophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design (2013)

Biophysical fragment screening of a thermostabilized β1-adrenergic receptor (β1AR) using surface plasmon resonance (SPR) enabled the identification of moderate affinity, high ligand efficiency (LE) arylpiperazine hits 7 and 8. Subsequent hit to lead follow-up confirmed the activity of the chemotype, and a structure-based design approach using protein-ligand crystal structures of the β1AR resulted in the identification of several fragments that bound with higher affinity, including indole 19 and quinoline 20. In the first example of GPCR crystallography with ligands derived from fragment screening, structures of the stabilized β1AR complexed with 19 and 20 were determined at resolutions of 2.8 and 2.7 Å, respectively.
Isolation of T cell receptors specifically reactive with mutated tumor associated antigens (2014)

Meeting abstracts The adoptive transfer of tumor infiltrating lymphocytes (TIL) can mediate the regression of metastatic melanoma [[1][1]]. In addition, the adoptive transfer of lymphocytes expressing T cell receptors (TCRs) specifically reactive with antigens expressed on melanoma cells can
The nature of active sites for carbon dioxide electroreduction over oxide-derived copper catalysts (2021)

The active sites for CO<sub>2</sub> electroreduction (CO<sub>2</sub>R) to multi-carbon (C<sub>2+</sub>) products over oxide-derived copper (OD-Cu) catalysts are under long-term intense debate. This paper describes the atomic structure motifs for product-specific active sites on OD-Cu catalysts in CO<sub>2</sub>R. Herein, we describe realistic OD-Cu surface models by simulating the oxide-derived process via the molecular dynamic simulation with neural network (NN) potential. After the analysis of over 150 surface sites through NN potential based high-throughput testing, coupled with density functional theory calculations, three square-like sites for C-C coupling are identified. Among them, Σ3 grain boundary like planar-square sites and convex-square sites are responsible for ethylene production while step-square sites, i.e. n(111) × (100), favor alcohols generation, due to the geometric effect for stabilizing acetaldehyde intermediates and destabilizing Cu-O interactions, which are quantitatively demonstrated by combined theoretical and experimental results. This finding provides fundamental insights into the origin of activity and selectivity over Cu-based catalysts and illustrates the value of our research framework in identifying active sites for complex heterogeneous catalysts.
Rilonacept (Interleukin‐1 Trap) in the prevention of acute gout flares during initiation of urate‐lowering therapy: Results of a phase II randomized, double‐blind, placebo‐controlled trial (2012)

The current findings indicate that rilonacept significantly reduces the frequency of gout flares during the initial period of treatment with urate-lowering therapy, with a favorable safety profile.
18‐3: Free Viewpoint Teleconferencing Using Cameras Behind Screen (2021)

Natural interaction in videoconferences can be made by correcting gaze/perspective, scale, and position by using cameras placed behind a partially transparent front emitting OLED panel and frame interpolation of deep neural networks. The diffraction artifacts from through‐screen imaging are removed by a deconvolution method.
Supplemental figure legends from Altered Expression and Splicing of <i>ESRP1</i> in Malignant Melanoma Correlates with Epithelial–Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity (2023)

&lt;p&gt;Figure legends for supplemental figures&lt;/p&gt;
Figure S5 from Modulation of Endoplasmic Reticulum Stress Controls CD4<sup>+</sup> T-cell Activation and Antitumor Function (2023)

&lt;p&gt;Cytosolic Ca2+ levels discriminate CD8+ T cell population&lt;/p&gt;
Feasibility of tracked electrodes for use in epilepsy surgery (2016)

Subdural electrode recording is commonly used to evaluate intractable epilepsy. In order to accurately record electrical activity responsible for seizure, electrodes must be positioned precisely near targets of interest, often indicated preoperatively through imaging studies. To achieve accurate placement, a large craniotomy is used to expose the brain surface. With the intent of limiting the size and improving the location of craniotomy for electrode placement, we examined magnetic tracking for localization of electrode strips. Commercially available electrode strips were attached to specialized magnetic tracking sensors developed by Medtronic plc. In a rigid phantom we evaluated the strips to determine the accuracy of electrode placement on targets. We further conducted an animal study to evaluate the impact of magnetic field interference during data collection. The measured distance between the physical fiducial and lead coil of the electrode strip was 1.32 &plusmn; 1.03mm in the phantom experiments. The tracking system induces a very strong signal in the electrodes in the Very Low Frequency, an International Telecommunication Union (ITU) designated frequency band, from 3 kHz to 30 kHz. The results of the animal experiment demonstrated both tracking feasibility and data collection.
Plant Nuclear Hormone Receptors: A Role for Small Molecules in Protein-Protein Interactions (2010)

Plant hormones are a group of chemically diverse small molecules that direct processes ranging from growth and development to biotic and abiotic stress responses. Surprisingly, genome analyses suggest that classic animal nuclear hormone receptor homologs do not exist in plants. It now appears that plants have co-opted several protein families to perceive hormones within the nucleus. In one solution to the problem, the hormones auxin and jasmonate (JA) act as &#x201C;molecular glue&#x201D; that promotes protein-protein interactions between receptor F-boxes and downstream corepressor targets. In another solution, gibberellins (GAs) bind and elicit a conformational change in a novel soluble receptor family related to hormone-sensitive lipases. Abscisic acid (ABA), like GA, also acts through an allosteric mechanism involving a START-domain protein. The molecular identification of plant nuclear hormone receptors will allow comparisons with animal nuclear receptors and testing of fundamental questions about hormone function in plant development and evolution.
Diels–Alders adducts of C60 and esters of 3-(1-indenyl)-propionic acid: alternatives for [60]PCBM in polymer:fullerene solar cells (2015)

A series of new, easily synthesized C60-fullerene derivatives is introduced that allow for optimization of the interactions between rr-P3HT and the fullerene by systematic variation of the size of the ester group. Two compounds gave overall cell efficiencies of 4.8%, clearly outperforming [60]PCBM which gives 4.3% under identical conditions.
1st International Workshop on Recognition Based Augmented Reality Summary (2015)

Summary form only given. The technology of AR has evolved to a point where there are well established methods to annotate the world using known markers, and more recently, the spatial 3D information on the environment itself. This has resulted in AR been nowadays widely experienced by a large number of people in a variety of situations. However, in order to take AR to the next level, it is essential to consider methods that allow the automated detection of objects, materials and shapes. One way to fulfil this goal is to develop AR that incorporates the recognition of visual object detection and use these to enhance the places and situations where current AR methods have not explored. Of interest for this goal are methods that include large-scale object recognition to distinguish and locate objects or materials, and go beyond using traditional markers. This workshop will showcase some examples of this nascent area and hopes to attract discussion among the ISMAR community of how best to incorporate object and pattern recognition that takes AR to the next levels.
Medium Chain Acylcarnitines Dominate the Metabolite Pattern in Humans under Moderate Intensity Exercise and Support Lipid Oxidation (2010)

Medium chain acylcarnitines were identified and characterized by a functional metabolomics approach as the dominating biomarkers during a moderately intense exercise bout possessing the power to support fat oxidation. This physiological production and efflux of acylcarnitines might exert beneficial biological functions in muscle tissue.
Stress fluctuations and shear thickening in dense granular suspensions (2020)

We experimentally investigate the rheology and stress fluctuations of granules densely suspended in silicone oil. We find that both thickening strength and stress fluctuations significantly weaken with oil viscosity η 0. Comparison of our rheological results to the Wyart–Cates model for describing different dynamic jamming states suggests a transition from frictional contacts to lubrication interactions as η 0 increases. To clarify the contribution from viscous interactions to the rheology, we systematically measure stress fluctuations in various flow states. Reduction of stress fluctuations with η 0 indicates that a strong lubrication layer greatly inhibits force correlations among particles. Measuring stress fluctuations in the strong shear thickening regime, we observe a crossover from asymmetric Gamma to symmetric Gaussian distributions and associated with it a decrease of lateral (radial) correlation length ξ with increasing shear rate.
Traitements adjuvants du cancer bronchique non à petites cellules (2002)

info:eu-repo/semantics/published
Wavelength switching and routing through evanescently induced absorption (2001)

High index contrast optical micro-ring resonators have previously been proposed for large scale integrated optical circuits. Additionally, absorption has been shown to be a use-ful mechanism for switching ring resonators. In this thesis, we propose Add / Drop and Cross-Connect architectures utilizing ring resonator switching elements. The performance requirements of the elements necessary to build Add / Drop and Cross-Connect switches are considered in detail. The on-state requirements of the switching elements are met by a high index contrast silicon-core silica-clad series coupled ring resonator pair. To avoid multimode excitation and the resultant multi-peaked filter responses commonly associated with ring resonators, the resonator guides are designed with effectively single-mode single-polarization waveguides. A flat filter passband, a steep roll-off, and a 10 Terahertz free spectral range are obtained, therein lending the design to large channel count Wavelength Division Multiplexed commu-nication (WDM) systems. The electro-absorptive techniques considered in prior works, are shown to provide insuf-
Introduction to ACM SIGMOD 2006 conference papers (2007)

No abstract available.
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6 (2013)

These results unambiguously demonstrate that metabolism of PQ by CYP 2D6 is essential for anti-malarial causal prophylaxis efficacy.
Generation of Gene-Specific Mutated Rats Using Zinc-Finger Nucleases (2009)

The genetic dissection of physiological and pathological traits in laboratory model organisms is accelerated by the ability to engineer loss-of-function mutations at investigator-specified loci. This chapter describes the use of zinc-finger nucleases (ZFNs) for the targeted disruption of endogenous rat genes directly in the embryo. ZFNs can specifically disrupt target genes in cultured rat cells and in embryos from inbred and outbred strains, leading to permanently genetically modified animals. This technology allows for the rapid, targeted modification of the rat genome.
Comparison of Amorphous TiO2 with Anatase Thin-Films Grown By ALD in Terms of Rate Performance and Capacity for Li+-Insertion (2015)

In this work we compare amorphous TiO 2 to anatase thin-films for their Li + insertion/extraction properties. For this, we deposited ultra-thin (35 nm) amorphous TiO 2 and anatase films by atomic layer deposition on a TiN current collector. Such thin films are interesting since they have the same length scale as nanostructured particles or other nanostructures, e.g. nanotubes, but with the additional benefit of offering a well-defined geometry that allows for a more precise determination of the underlying lithium insertion/extraction kinetics. Furthermore, such ultra-thin electrodes might find application in 3D (micro-)batteries. The amorphous and anatase films were characterized using cyclic voltammetry and galvanostatic charging/discharging. The electrochemical properties of 35 nm amorphous TiO 2 and anatase films are shown in figure 1. The cyclic voltammograms (CV, see figure 1a) performed at 10 mV/s shows distinction between lithium insertion/extraction of the amorphous and anatase films. The average of the insertion and extraction peak potentials is 1.65 V vs Li + /Li and 1.99 V vs Li + /Li for amorphous and anatase, respectively. Also, the peaks in the CV for amorphous TiO 2 are less sharp compared to anatase, suggesting a different intercalation mechanism. Galvanostatic charge/discharge experiments show a significantly increased capacity for amorphous compared to anatase (see figure 1b). At 1C, the amorphous TiO 2 film has a capacity of 1.9 µAh/cm 2 compared to 1.2 µAh/cm 2 for the anatase film. Also, at higher C-rates the amorphous TiO 2 film shows high retention of the capacity. For example, at 20C, 63% of the capacity at 1C is retained, compared to 30% for anatase. These results show the potential benefits of using amorphous TiO 2 compared to anatase thin-films due to its significantly higher capacity and superior rate performance. Figure 1
Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEngineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificitiesRobert McDaniel, Susanne Ebert-Khosla, David A. Hopwood, and Chaitan KhoslaCite this: J. Am. Chem. Soc. 1993, 115, 25, 11671–11675Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00078a002https://doi.org/10.1021/ja00078a002research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Conferols A and B, New Antiinflammatory 4‐Hydroxyisoflavones from Caragana conferta. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A host-protein signature is superior to other biomarkers for differentiating between bacterial and viral disease in patients with respiratory infection and fever without source: a prospective observational study (2018)

Bacterial and viral infections often present with similar symptoms. Etiologic misdiagnosis can alter the trajectory of patient care, including antibiotic overuse. A host-protein signature comprising tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP) was validated recently for differentiating bacterial from viral disease. However, a focused head-to-head comparison of its diagnostic performance against other biomarker candidates for this indication was lacking in patients with respiratory infection and fever without source. We compared the signature to other biomarkers and prediction rules using specimens collected prospectively at two secondary medical centers from children and adults. Inclusion criteria included fever > 37.5 °C, symptom duration ≤ 12 days, and presentation with respiratory infection or fever without source. Comparator method was based on expert panel adjudication. Signature and biomarker cutoffs and prediction rules were predefined. Of 493 potentially eligible patients, 314 were assigned unanimous expert panel diagnosis and also had sufficient specimen volume. The resulting cohort comprised 175 (56%) viral and 139 (44%) bacterial infections. Signature sensitivity 93.5% (95% CI 89.1-97.9%), specificity 94.3% (95% CI 90.7-98.0%), or both were significantly higher (all p values < 0.01) than for CRP, procalcitonin, interleukin-6, human neutrophil lipocalin, white blood cell count, absolute neutrophil count, and prediction rules. Signature identified as viral 50/57 viral patients prescribed antibiotics, suggesting potential to reduce antibiotic overuse by 88%. The host-protein signature demonstrated superior diagnostic performance in differentiating viral from bacterial respiratory infections and fever without source. Future utility studies are warranted to validate potential to reduce antibiotic overuse.