gebhart/patrepeval huggingface dataset:
1086: Ultrasound-Mediated Microbubble Destruction to Direct Antisense Molecules into Prostate Cancer Cells in Vitro (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 1:00 - 5:00 pm1 Apr 20041086: Ultrasound-Mediated Microbubble Destruction to Direct Antisense Molecules into Prostate Cancer Cells in Vitro Iris E. Eder, Ferdinand Frauscher, Jonathan R. Lindner, Alexander L. Klibanov, Thomas Putz, Petra Haag, Georg Bartsch, and Helmut Klocker Iris E. EderIris E. Eder More articles by this author , Ferdinand FrauscherFerdinand Frauscher More articles by this author , Jonathan R. LindnerJonathan R. Lindner More articles by this author , Alexander L. KlibanovAlexander L. Klibanov More articles by this author , Thomas PutzThomas Putz More articles by this author , Petra HaagPetra Haag More articles by this author , Georg BartschGeorg Bartsch More articles by this author , and Helmut KlockerHelmut Klocker More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38323-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1086: Ultrasound-Mediated Microbubble Destruction to Direct Antisense Molecules into Prostate Cancer Cells in Vitro." The Journal of Urology, 171(4S), p. 286 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 286 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Iris E. Eder More articles by this author Ferdinand Frauscher More articles by this author Jonathan R. Lindner More articles by this author Alexander L. Klibanov More articles by this author Thomas Putz More articles by this author Petra Haag More articles by this author Georg Bartsch More articles by this author Helmut Klocker More articles by this author Expand All Advertisement PDF DownloadLoading ...
Infection of Macrophages and Dendritic Cells with Primary R5-Tropic Human Immunodeficiency Virus Type 1 Inhibited by Natural Polyreactive Anti-CCR5 Antibodies Purified from Cervicovaginal Secretions (2008)

Heterosexual contact is the primary mode of human immunodeficiency virus (HIV) type 1 (HIV-1) transmission worldwide. The chemokine receptor CCR5 is the major coreceptor that is associated with the mucosal transmission of R5-tropic HIV-1 during sexual intercourse. The CCR5 molecule is thus a target for antibody-based therapeutic strategies aimed at blocking HIV-1 entry into cells. We have previously demonstrated that polyreactive natural antibodies (NAbs) from therapeutic preparations of immunoglobulin G and from human breast milk contain NAbs directed against CCR5. Such antibodies inhibit the infection of human macrophages and T lymphocytes by R5-tropic isolates of HIV in vitro. In the present study, we demonstrate that human immunoglobulins from the cervicovaginal secretions of HIV-seronegative or HIV-seropositive women contain NAbs directed against the HIV-1 coreceptor CCR5. Natural affinity-purified anti-CCR5 antibodies bound to CCR5 expressed on macrophages and dendritic cells and further inhibited the infection of macrophages and dendritic cells with primary and laboratory-adapted R5-tropic HIV but not with X4-tropic HIV. Natural anti-CCR5 antibodies moderately inhibited R5-tropic HIV transfer from monocyte-derived dendritic cells to autologous T cells. Our results suggest that mucosal anti-CCR5 antibodies from healthy immunocompetent donors may hamper the penetration of HIV and may be suitable for use in the development of novel passive immunotherapy regimens in specific clinical settings of HIV infection.
Real-time Computer Modeling of Woodwind Instruments (1998)

Abstract: This paper presents a digital waveguide woodwind instrument tonehole implementation which, in a single model, characterizes all states of the hole from open to closed. This efficient implementation produces results which agree well with previous acoustical analyses of the tonehole. A similar model is also presented for the register hole. A complete woodwind instrument model with many toneholes and register hole(s) is implemented in a cross-platform, C++ real-time computer programming environment. A new wind controller created to control the woodwind model is also briefly discussed.
Frequency-Domain Quantum Interference with Correlated Photons from an Integrated Microresonator (2020)

Frequency encoding of quantum information together with fiber and integrated photonic technologies can significantly reduce the complexity and resource requirements for realizing all-photonic quantum networks. The key challenge for such frequency domain processing of single photons is to realize coherent and selective interactions between quantum optical fields of different frequencies over a range of bandwidths. Here, we report frequency-domain Hong-Ou-Mandel interference with spectrally distinct photons generated from a chip-based microresonator. We use four-wave mixing to implement an active "frequency beam splitter" and achieve interference visibilities of 0.95±0.02. Our work establishes four-wave mixing as a tool for selective high-fidelity two-photon operations in the frequency domain which, combined with integrated single-photon sources, provides a building block for frequency-multiplexed photonic quantum networks.
Characteristic Views Extraction Modal Based-on Deep Reinforcement Learning for 3D Model Retrieval (2019)

In this paper, we propose an effective framework for view-based 3D model retrieval based on reinforcement learning, which aims to extract the most important views from the view set of 3D models for model representation. Since the choice of the representative views can be treated as a Markov decision process (MDP), we model the view extraction as a progressive process through deep reinforcement learning. First, the visual tool developed by OpenGL is utilized to extract 12 rendered pictures in order from a 3D model. Second, these 12 views are fed into the network as a view-based sequence, and then we utilize characteristic views extraction model to extract the most informative views of the 3D model. Finally, a similarity measure between 3D models is performed to complete the last step pf the model retrieval problem. In the experiment section, the classic ModelNet40 is utilized to evaluate the performance of the proposed method. Extensive experiments and corresponding experimental results have demonstrated the superiority of our approach.
Effect of specimen size and shape on strength and deformation of high-purity aluminum single-crystal micropillars (2018)

In the present study, we have examined the compression response of single-crystal cylindrical micropillars with different diameters (approximately ranging from 1 to 10 µm) and shape parameters prepared on the sample surface of 4N purity aluminum (Al) sheets with the recrystallized microstructure. The compression tests for micropillars with various sizes demonstrated the flow stress of micropillars increases with decreasing pillar diameter. The observed size dependence of resolved shear stress for slip corresponds well to the previous studies on micropillars prepared from 3N and 5N purity Al sheets. The measured shear stress resolved onto a primary slip system (τi) scaled by shear modulus (G) and the pillar diameter (d) scaled by Burgers vector (b) shows the following correlation: (τi/G)=0.33(d/b)−0.63. The compression response of micropillars with different d1/d2 (ratio of top diameter (d1) to bottom diameter (d2) of cylindrical micropillars) revealed higher d1/d2 than 0.5 is required for precisely measuring the strength of cylindrical micropillars, which was confirmed by the observations of compressed micropillars.
Involvement of 4-hydroxymandelic acid in the degradation of mandelic acid by Pseudomonas convexa (1976)

A microorganism capable of degrading DL-mandelic acid was isolated from sewage sediment of enrichment culture and was identified as Pseudomonas convexa. It was found to metabolize mandelic acid by a new pathway involving 4-hydroxymandelic acid, 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid, and 3,4-dihydroxybenzoic acid as aromatic intermediates. All the enzymes of the pathway were demonstrated in cell-free extracts. L-Mandelate-4-hydroxylase, a soluble enzyme, requires tetrahydropteridine, nicotinamide adenine dinucleotide phosphate, reduced form, and Fe2+ for its activity. The next enzyme, L-4-hydroxymandelate oxidase (decarboxylating), a particulate enzyme, requires flavine adenine dinucleotide and Mn2+ for its activity. A nicotinamide adenine dinucleotide-dependent, as well as a nicotinamide adenine dinucleotide phosphate-dependent, benzaldehyde dehydrogenase has been resolved and partially purified.
In vivo repopulation of decellularized bovine jugular valved vein grafts with autologous cells occurs in sheep when implanted in pulmonary valve position (2007)

Introduction: Glutaraldehyd fixed bovine jugular valved vein grafts („Contegra“) used for reconstruction of the pulmonary outflow tract are unable to grow. The aim of this study was to investigate the performance of not fixed but decellularized bovine jugular valved vein grafts implanted in pulmonary position in respect to function, cellular repopulation – a prerequisite for potential growth –, and morphology in the sheep model.
Retroperitoneoscopic Living Donor Nephrectomy: A Retrospective Comparison to the Open Approach (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Feb 2005Retroperitoneoscopic Living Donor Nephrectomy: A Retrospective Comparison to the Open Approach Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)60514-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Retroperitoneoscopic Living Donor Nephrectomy: A Retrospective Comparison to the Open Approach." The Journal of Urology, 173(2), pp. 480–481 © 2005FiguresReferencesRelatedDetails Volume 173Issue 2February 2005Page: 480-481 Advertisement Copyright & Permissions© 2005MetricsAuthor Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Evolution-based discovery of hierarchical behaviors (1996)

Procedural representations of control policies have two advantages when facing the scale-up problem in learning tasks. First they are implicit, with potential for inductive generalization over a very large set of situations. Second they facilitate modularization. In this paper we compare several randomized algorithms for learning modular procedural representations. The main algorithm, called Adaptive Representation through Learning (ARL) is a genetic programming extension that relies on the discovery of subroutines. ARL is suitable for learning hierarchies of subroutines and for constructing policies to complex tasks. ARL was successfully tested on a typical reinforcement learning problem of controlling an agent in a dynamic and nondeterministic environment where the discovered subroutines correspond to agent behaviors. Introduction The interaction of a learning system with a complex environment represents an opportunity to discover features and invariant properties of the problem th...
Synthesis and Initial Structure−Activity Relationships of Modified Salicylihalamides (2000)

[reaction:see text] The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.
Geometric Data Augmentation Based on Feature Map Ensemble (2021)

Deep convolutional networks have become the mainstream in computer vision applications. Although CNNs have been successful in many computer vision tasks, it is not free from drawbacks. The performance of CNN is dramatically degraded by geometric transformation, such as large rotations. In this paper, we propose a novel CNN architecture that can improve the robustness against geometric transformations without modifying the existing backbones of their CNNs. The key is to enclose the existing backbone with a geometric transformation (and the corresponding reverse transformation) and a feature map ensemble. The proposed method can inherit the strengths of existing CNNs that have been presented so far. Furthermore, the proposed method can be employed in combination with state-of-the-art data augmentation algorithms to improve their performance. We demonstrate the effectiveness of the proposed method using standard datasets such as CIFAR, CUB-200, and Mnist-rot-12k.
Refractive-index profile and physical process determination in thick gratings in electrooptic crystals (1976)

A method for determining the refractive index profile of thick phase gratings in linear electrooptic crystals is presented. This method also determines the effective photovoltaic electric field and the relative contributions of diffusion and drift during hologram recording. The method requires only a knowledge of the modulation ratio during hologram recording and the fundamental and the higher-order diffraction efficiencies of the grating. As an illustration of the method, the refractive index profile, the effective photovoltaic field, and the relative contributions of diffusion and drift are determined from experimental measurements for a lithium niobate holographic grating.
ChemInform Abstract: Chiral Synthesis via Organoboranes. Part 13. A Highly Diastereoselective and Enantioselective Addition of ((Z)‐γ‐Alkoxyallyl)diisopinocampheylboranes to Aldehydes. (1988)

Abstract The isomerically pure borane (III) is prepared from the olefin (I) and the (+)‐α‐pinene‐derived compound (II).
Recommendations for ventilation during cardiopulmonary resuscitation (1985)

From the Departments of Anesthesiology. Pediatries, and Surgery. University of Florida College of Medicine, Gainesville, Fl.
Patients with newly diagnosed cervical cancer should be screened for anal human papilloma virus and anal dysplasia: Results of a pilot study using a STELLA computer simulation and economic model (2017)

Screening for anal HPV and treatment of anal HSIL in patients with cervical cancer is cost-effective, prevents anal cancer and reduces anal cancer deaths.
Effects of Ovariectomy on GnRH mRNA, proGnRH and GnRH Levels in the Preoptic Hypothalamus of the Female Rat (1989)

Experiments were carried out to investigate the effects of ovariectomy on gonadotropin-releasing hormone (GnRH) messenger RNA (mRNA), proGnRH and GnRH peptide levels in the hypothalamus of female rats. Intact proestrous female rats and female rats, which had been ovariectomized for 2 weeks, were sacrificed at 9.00 h and the preoptic area (POA) and basal hypothalamus (BH) were dissected out and frozen on dry ice. One group of tissues from proestrous control and ovariectomized females were extracted in acetic acid, centrifuged at 13,000 g and the supernatant purified on a C18 column. The purified extract was then radioimmunoassayed for proGnRH, using a specific antiserum to rat proGnRH (ARK-2), and for GnRH using the E1-14 antiserum. Total cellular RNA was isolated from another group of tissues and prepared as Northern blots. Hybridization with 32P-labeled GnRH cRNA was used to detect GnRH mRNA. A third group of proestrous and ovariectomized female rats were perfused, and 50 microns vibratome sections were cut. These were immunostained with proGnRH or GnRH antiserum, followed by in situ hybridization with 35S-labeled GnRH cRNA to detect GnRH mRNA. Based on the histochemical staining, mRNA was colocalized to the cell soma of neurons containing proGnRH and GnRH throughout the POA and BH. Based on the radioimmunoassay, proGnRH levels were 2 times higher in the POA versus the BH, but GnRH levels were 6-7 times higher in the BH. Ovariectomy significantly decreased proGnRH levels in both the POA and BH, while GnRH decreased in the BH. In contrast, quantitative Northern blot analysis demonstrated that ovariectomy had no effect on mRNA levels in the POA and BH. These data indicate that the effects of ovariectomy on proGnRH and GnRH levels are a result of altered translation, posttranslational processing and/or secretion of GnRH.
Degradation Characteristics of Electrospun Gas Diffusion Layers with Custom Pore Structures for Polymer Electrolyte Membrane Fuel Cells (2021)

Electrospinning has been demonstrated to be a versatile technique for producing hydrophobic gas diffusion layers (GDLs) with customized pore structures for the enhanced performance of polymer electrolyte membrane (PEM) fuel cells. However, the degradation characteristics of custom hydrophobic electrospun GDLs (eGDLs) have not yet been explored. Here, for the first time, we investigate the degradation characteristics of custom hydrophobic eGDLs via an ex situ accelerated degradation protocol using H<sub>2</sub>O<sub>2</sub>. The surface contact angle of degraded eGDLs (44 ± 12°) was lower than that of pristine eGDLs (137 ± 6°). The loss of hydrophobicity was attributed to the degradation (via hydrolysis) of the fluorinated monolayers (formed via a direct fluorination treatment) on the electrospun carbon fiber surfaces as evidenced by the reduction in surface fluorine content. Degradation of the surface monolayers affected fuel cell performance under multiple operating conditions. At 100% relative humidity (RH), the loss of monolayers led to higher liquid water content and lower cell voltages compared to the pristine eGDL. At 50% RH, the degraded eGDL led to lower cell voltages due to the lower electrical conductivity of the degraded materials. The lower electrical conductivity was attributed to the oxidation of carbon fibers upon loss of the monolayers. Our results indicate the importance of designing robust hydrophobic surface treatments for the advancement of customized GDLs for effective long-term fuel cell operation.
Efficiency improvement of human body detection with histograms of oriented gradients (2008)

In this paper we investigate improvements to the efficiency of human body detection using histograms of oriented gradients (HOG). We do this without compromising the performance significantly. This is especially relevant for embedded implementations in smart camera systems, where the on-board processing power and memory is limited. We focus on applications for indoor environments such as offices and living rooms. We present different experiments to reduce both the computational complexity as well as the memory requirements for the trained model. Since the HOG feature length is large, the total memory size needed for storing the model can become more than 50 MB. We use a feature selection based on Bayesian theory to reduce the feature length. Additionally we compare the performance of the full-body detector with an upper-body only detector. For computational complexity reduction we employ a ROI-based approach.
In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages (2016)

The lipopolysaccharide (O) and flagellar (H) surface antigens of <i>Escherichia coli</i> are targets for serotyping that have traditionally been used to identify pathogenic lineages. These surface antigens are important for the survival of <i>E. coli</i> within mammalian hosts. However, traditional serotyping has several limitations, and public health reference laboratories are increasingly moving towards whole genome sequencing (WGS) to characterize bacterial isolates. Here we present a method to rapidly and accurately serotype <i>E. coli</i> isolates from raw, short read WGS data. Our approach bypasses the need for <i>de novo</i> genome assembly by directly screening WGS reads against a curated database of alleles linked to known and novel <i>E. coli</i> O-groups and H-types (the EcOH database) using the software package srst2. We validated the approach by comparing <i>in silico</i> results for 197 enteropathogenic <i>E. coli</i> isolates with those obtained by serological phenotyping in an independent laboratory. We then demonstrated the utility of our method to characterize isolates in public health and clinical settings, and to explore the genetic diversity of >1500 <i>E. coli</i> genomes from multiple sources. Importantly, we showed that transfer of O- and H-antigen loci between <i>E. coli</i> chromosomal backbones is common, with little evidence of constraints by host or pathotype, suggesting that <i>E. coli '</i>strain space' may be virtually unlimited, even within specific pathotypes. Our findings show that serotyping is most useful when used in combination with strain genotyping to characterize microevolution events within an inferred population structure.
[Antigens of Toxoplasma gondii with a diagnostic and potential immunoprophylactic value: new strategies of identification]. (1989)

Toxoplasma gondii is an ubiquitous protozoan parasite which induces severe pathology in in utero infected children and in immunosuppressed patients (particularly in the case of AIDS). Previous work that focused on toxoplasma somatic antigens failed to demonstrate an efficient protection against highly virulent T. gondii strains. The authors therefore first studied the role of parasite excreted-secreted (ES) antigens in the immune response. They describe here the preparation of excreted-secreted antigens in cell-free medium from tachyzoites, the intracellular proliferative stage present during acute infection. Major ES antigens have Mr of 108 K, 97 K, 86 K, 57 K, 42 K, 39 K, 28.5 K, 27 K and 21 K. The protective role of ES antigens has been demonstrated using congenitally athymic (Nu/Nu) rats that are highly sensitive to T. gondii infection (+/+ Fischer rats are resistant). The humoral and cellular components of this protection have been studied by the passive transfer either of sera or of T lymphocytes from ES-immunized +/+ Fischer rats into Nu/Nu rats. Adoptive transfers were carried out 24 hours before infection with the highly virulent T. gondii RH strain. Based on the concept of concomitant immunity, the authors have characterized antigens from tachyzoites and bradyzoites (the encysted stage persisting during chronic infection) which share common epitopes. Four tachyzoite antigens, P63, GP43, P39 and GP 28.5 have been shown by immunoprecipitation to cross-react with bradyzoite antigens. Two monoclonal antibodies raised against ES antigens permitted to demonstrate the localization of the 28.5 K and 27 K antigens inside the dense granules of tachyzoites and bradyzoites.(ABSTRACT TRUNCATED AT 250 WORDS)
The Trusted Domain Machine: A Secure Communication Device For Security Guard Applications (1986)

The Trusted Domain Machine (TDM) is a secure communication device for security guard applications. Its design isolates the security-critical functions into a physically isolated processing domain. This trusted physical domain includes a layer of core software that allows applications that are implemented on the TDM to control interdomain communication. The security-relevant application software is further separated into execution domains within the trusted domain to simplify its verification.
Selective activation of hippocampal neurons (1979)

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