gebhart/patrepeval huggingface dataset:
A patient-driven clinicogenomic partnership for metastatic prostate cancer (2022)

Molecular profiling studies have enabled discoveries for metastatic prostate cancer (MPC) but have predominantly occurred in academic medical institutions and involved non-representative patient populations. We established the Metastatic Prostate Cancer Project (MPCproject, mpcproject.org), a patient-partnered initiative to involve patients with MPC living anywhere in the US and Canada in molecular research. Here, we present results from our partnership with the first 706 MPCproject participants. While 41% of patient partners live in rural, physician-shortage, or medically underserved areas, the MPCproject has not yet achieved racial diversity, a disparity that demands new initiatives detailed herein. Among molecular data from 333 patient partners (572 samples), exome sequencing of 63 tumor and 19 cell-free DNA (cfDNA) samples recapitulated known findings in MPC, while inexpensive ultra-low-coverage sequencing of 318 cfDNA samples revealed clinically relevant <i>AR</i> amplifications. This study illustrates the power of a growing, longitudinal partnership with patients to generate a more representative understanding of MPC.
ADVANCED TECHNOLOGY IN THE DESIGN OF RAILROAD ROLLING STOCK (1973)

Requirements which modern railroad cars have to satisfy are listed and their consequences for their structural design and the materials used are discussed. Application of advanced technology, in particular the use of light alloys, stainless steel, plastics, adhesives, etc., for railroad car construction is surveyed. Examples of realization for the Circumvesuviana Railroad and for the Milan and Rome subways are presented.
Let's Talk About X (2017)

Communicating at a natural speed is a significant challenge for users of augmentative and alternative communication (AAC) devices, especially when input is provided by eye gaze, as is common for people with ALS and similar conditions. One way to improve AAC throughput is by drawing on contextual information from the outside world. Toward this goal, we present SceneTalk, a prototype gaze-based AAC system that uses computer vision to identify objects in the user's field of view and suggests words and phrases related to the current scene. We conducted a formative evaluation of SceneTalk with six people with ALS, in which we evaluated their preference for user interface modes and output preferences. Participants agreed that integrating contextual awareness into their AAC device could be helpful across a diverse range of situations.
Antibodies induced by immunization with a hypoallergenic mutant of the major fish allergen Cyp c 1 inhibit allergic symptoms in a mouse model of fish allergy (2013)

Background Fish allergy is one of the most frequently occurring allergies to animal-derived food and may cause severe anaphylactic reactions. Currently allergen-specific immunotherapy for fish allergy is not available as it may induce severe side-effects. A hypoallergenic mutant of the major carp allergen Cyp c 1 (mCyp c 1) has recently been developed for the treatment of IgE-mediated fish allergy. We analysed the effect of antibodies induced by immunization with mCyp c 1 on allergic symptoms in a mouse model of fish allergy.
Chemistry of IronN-Heterocyclic Carbene Complexes: Syntheses, Structures, Reactivities, and Catalytic Applications (2014)

Iron is the most abundant transition metal in Earth's crust. It is relatively inexpensive, not very toxic, and environmentally benign. Undoubtedly, due to the involvement in a multitude of biological processes, which heavily rely on the rich functionalities of iron-containing enzymes, iron is one of the most important elements in nature. Additionally, three-coordinate iron complexes have been reported during the past several years. In this review, the mentioned iron NHC complexes are categorized by their main structure and reactivity attributes. Thus, monocarbene and bis-monocarbene complexes are presented first. This class is subdivided into carbonyl, nitrosyl, and halide compounds followed by a brief section on other, more unconventional iron NHC motifs. Subsequently, donor-substituted complexes bearing bi-, tri-, tetra-, or even pentadentate ligands and further pincer as well as scorpionato motifs are described.
Studying Regioisomer Formation in the Pd‐Catalyzed Fluorination of Cyclic Vinyl Triflates: Evidence for in situ Ligand Modification** (2023)

Pd-catalyzed nucleophilic fluorination reactions are important methods for the synthesis of fluoroarenes and fluoroalkenes. However, these reactions can generate a mixture of regioisomeric products that are often difficult to separate. While investigating the Pd-catalyzed fluorination of cyclic vinyl triflates, we observed that the addition of a substoichiometric quantity of TESCF<sub>3</sub> significantly improved the regioselectivity of the reaction. Herein, we report a combined experimental and computational study on the mechanism of this transformation focusing on the role of TESCF<sub>3</sub> . The poor regioselectivity of the reaction in the absence of additives results from the formation of LPd-cyclohexyne complexes (L=biaryl monophosphine ligand). When TESCF<sub>3</sub> is added to the reaction mixture, the generation of the Pd-cyclohexyne complexes is diminished by an unexpected pathway involving the dearomatization of the ligand by nucleophilic attack from a trifluoromethyl anion (CF<sub>3</sub> <sup>-</sup> ).
PTH-077 De-escalating therapy in patients with crohn’s disease receiving adalimumab: subgroup analysis of the calm study (2019)

<h3>Introduction</h3> This analysis evaluated the impact of de-escalating therapy on mucosal healing 48 weeks (wks) after randomization in patients (pts) with Crohn’s disease (CD) in the CALM study. <h3>Methods</h3> Pts with moderate-to-severe CD naïve to immunomodulators and biologics were randomized 1:1 to a tight control group (TCG) or clinical management group (CMG) after 8 wks of prednisone therapy. Treatment was escalated from no treatment to 40 mg adalimumab (ADA) every other wk (EOW) to 40 mg ADA every wk (EW) to 40 mg ADA EW+2.5 mg/kg azathioprine (AZA)/day at 12, 24, and 36 wks after randomization based on failure criteria (CD Activity Index [CDAI]=200 or decrease &lt;70 points [1 wk pre-randomisation] or &lt;100 points versus baseline [at wk 11, 23, 35] and prednisone use for the CMG; CDAI=150, C-reactive protein=5 mg/L, faecal calprotectin=250µg/g, and prednisone use for the TCG). At 24 and 36 wks, if failure criteria were not met, patients de-escalated ADA EW dose to 40 mg ADA EOW. Pts re-escalated if failure criteria were met at the next visit. The primary endpoint (mucosal healing [CD Endoscopic Index of Severity &lt;4] and no deep ulcers at 48 wks post-randomisation) was evaluated in pts who de-escalated treatment. Analyses were performed in pts who completed the study and did not move to rescue therapy. Non-responder imputation was used for missing data. <h3>Results</h3> 15 pts in the CMG and 31 pts in the TCG de-escalated treatment during the study. Of those, 2 pts in the CMG and 8 pts in the TCG re-escalated to 40 mg ADA EW. Overall, 54% of pts in the CMG and 61% of pts in the TCG who de-escalated to 40 mg ADA EOW ± AZA achieved the primary endpoint (table 1). Of the pts who re-escalated to ADA EW, 0% in the CMG, and 75% in the TCG achieved the primary endpoint (table 1). The overall adverse event rates have been previously reported (Colombel, 2018) <h3>Conclusions</h3> Our data suggest that repeated dose optimization based on tight control is a more refined approach resulting in mucosal healing compared with clinical management. Larger data sets are needed to confirm our observation on repeated dose optimization. <h3>Reference</h3> Colombel, et al. <i>Lancet</i> 2018;390:2779–89.
Protein Extraction from Heat‐stabilized Defatted Rice Bran: II. The Role of Amylase, Celluclast, and Viscozyme (2003)

ABSTRACT: The effectiveness of 3 carbohydrases for protein extraction from heat‐stabilized defatted rice bran (HDRB) was evaluated. Amylase, viscozyme and celluclast extracted a maximum of 45.4, 12.1, and 28.5% protein, respectively. Further study showed that extracted protein ranged from 9.5 to 58.4% under conditions of water to bran ratio (5:1 to 20:1), α‐amylase (0 to 110000 units/10 g rice bran), temperature (35 to 55 °C), and time (1 to 8 h). The maximum protein extracted was 58.4% with a water to bran ratio of 17:1, 87637 units amylase, and 50.9 °C. These results suggest that impure food‐grade amylase containing protease is more effective than celluclast and viscozyme in protein extraction from HDRB.
Honey I shrunk the world (2007)

This article provides a brief snapshot of some of the agricultural, biological, electronics, medical, and manufacturing applications currently under active research and development at the University of Illinois Center for Nanoscale Silence and Technology (CNST) collaboratory. The trend has been to prefix the word nano to any application (such as nanoagriculture, nanoelectronics, nanomedicine, etc.) that leverages features at the nanoscale to design and develop materials, processes, sensors, devices, and systems.
How do T-type calcium channels control low-threshold exocytosis? (2012)

Low-voltage-activated T-type calcium channels act as a major pathway for calcium entry near the resting membrane potential in a wide range of neuronal cell types. Several reports have uncovered an unrecognized feature of T-type channels in the control of vesicular neurotransmitter and hormone release, a process so far thought to be mediated exclusively by high-voltage-activated calcium channels. However, the underlying molecular mechanisms linking T-type calcium channels to vesicular exocytosis have remained enigmatic. In a recent study, we have reported that Ca(v)3.2 T-type channel forms a signaling complex with the neuronal Q-SNARE syntaxin-1A and SNAP-25. This interaction that relies on specific Ca(v)3.2 molecular determinants, not only modulates T-type channel activity, but was also found essential to support low-threshold exocytosis upon Ca(v)3.2 channel expression in MPC 9/3L-AH chromaffin cells. Overall, we have indentified an unrecognized regulation pathway of T-type calcium channels by SNARE proteins, and proposed the first molecular mechanism by which T-type channels could mediate low-threshold exocytosis.
Differential Expression and Network Inferences through Functional Data Modeling (2008)

Time course microarray data consist of mRNA expression from a common set of genes collected at different time points. Such data are thought to reflect underlying biological processes developing over time. In this article, we propose a model that allows us to examine differential expression and gene network relationships using time course microarray data. We model each gene-expression profile as a random functional transformation of the scale, amplitude, and phase of a common curve. Inferences about the gene-specific amplitude parameters allow us to examine differential gene expression. Inferences about measures of functional similarity based on estimated time-transformation functions allow us to examine gene networks while accounting for features of the gene-expression profiles. We discuss applications to simulated data as well as to microarray data on prostate cancer progression.
Polymorphisms in the thallus morphogenesis ofSphaerocarpos donnelliiAust. as a result of different substrate combinations (1981)

Sphaerocarpos donnellii Aust. develops a substrate-specific morphology when grown under sterile conditions on the same medium for a period of 10 months. Media containing monosaccharides gave an increase in total chlorophyll content, and increase in growth rates of 35-50% and increased the production of sexual organs.
Analysis of Security Frameworks for Mobile Cloud (2016)

The concept of Mobile Cloud Computing is relatively new in the research. It brings various advantages for mobile devices since it enables the use of Cloud resources and services. This paper gives a survey of MCC security frameworks, which helps general readers have an overview of the MCC. The issues, existing solutions, and approaches are presented. The paper is organized as follows. In the next section, we will go through some papers and get a brief idea about MCC, which helps general readers have an overview of the MCC. The issues, existing solutions, and what is actually going on in the current cloud based mobile security research and analyze two frameworks for security of mobile cloud computing.
Tyrosine‐Targeted Spin Labeling and EPR Spectroscopy: An Alternative Strategy for Studying Structural Transitions in Proteins (2011)

Tyrosin im Blick: Durch eine Mannich-Dreikomponentenreaktion gelingt die ortsselektive Spinmarkierung des Tyrosinrests im CP12-Protein (siehe Bild). Die EPR-spektroskopische Untersuchung des markierten Proteins zeigte, dass die Sonde auch nach der Komplexierung mit GAPDH ihre hohe Mobilität beibehält.
Patient outcomes after circumferential minimally invasive surgery compared with those of open correction for adult spinal deformity: initial analysis of prospectively collected data (2021)

When cMIS was compared with open adult scoliosis correction with propensity matching, HRQOL improvement, spinopelvic parameters, revision surgery rates, and proportions of patients who reached MCID were similar between cohorts. However, well-selected cMIS patients had less blood loss, comparable results, and longer operative times in comparison with open patients.
Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs). (2021)

An established antiviral T cell memory may turn out to be an anticancer T cell memory, able to control the growth of a cancer developed during the lifetime if the expressed TAA is similar to the viral epitope. This may ultimately represent a relevant selective advantage for patients with cancer and may lead to a novel preventive anticancer vaccine strategy.
Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model (2019)

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known, with a human LD<sub>50</sub> of ~1 ng/kg. Equine antitoxin has a half-life in circulation of less than 1 day and is limited to a treatment rather than a prevention indication. The development of monoclonal antibodies (mAbs) may represent an alternative therapeutic option that can be produced at high quantities and of high quality and with half-lives of >10 days. Two different three mAb combinations are being developed that specifically neutralize BoNT serotypes A (BoNT/A) and B (BoNT/B). We investigated the pharmacokinetics of the anti-BoNT/A and anti-BoNT/B antibodies in guinea pigs (<i>Cavia porcellus</i>) and their ability to protect guinea pigs against an aerosol challenge of BoNT/A1 or BoNT/B1. Each antibody exhibited dose-dependent exposure and reached maximum circulating concentrations within 48 h post intraperitoneal or intramuscular injection. A single intramuscular dose of the three mAb combination protected guinea pigs against an aerosol challenge dose of 93 LD<sub>50</sub> of BoNT/A1 and 116 LD<sub>50</sub> of BoNT/B1 at 48 h post antibody administration. These mAbs are effective in preventing botulism after an aerosol challenge of BoNT/A1 and BoNT/B1 and may represent an alternative to vaccination to prevent type A or B botulism in those at risk of BoNT exposure.
Physiological and Hemodynamic Evaluation of Nonuniform Direct Cardiac Compression (1999)

Nonuniform DCC significantly improves the left and right ventricular pressure-generating capability and, in the setting of acute heart failure, can increase CO and mean arterial pressure. Such DCC devices can potentially avoid the complications associated with currently available ventricular support devices that involve a blood/device interface.
Bifurcation and frequency analysis of mutually delay-coupled semiconductor lasers in photonic integrated circuits (2017)

A system of two mutually delay-coupled semiconductor lasers for integration in a photonic integrated circuit is investigated. Multi-stabilities and bifurcation scenarios are presented, followed by a comprehensive frequency analysis of the symmetric and symmetry-broken, 1-colour and 2-colour states.
Lissage anisotrope Doppler par extension de l'opérateur de diffusion de Laplace-Beltrami dans le cadre de la géométrie Riemannienne de l'information de Chentsov (2003)

Resume – Nous traitons le probleme du debruitage spatial de l’estimation des parametres de lois statistiques grâce au flot geometrique nonlineaire de Laplace-Beltrami. Cet operateur , recemment introduit par N. Sochen et R. Kimmel [2] en traitement d’image, est etendu au cas d’un espace hybride forme des coordonnees spatiales (geometrie Euclidienne de la mesure) et des parametres des lois statistiques (geometrie de l’information de Chentsov dont la metrique est donnee par la matrice d’information de Fisher). Cet operateur EDP agissant intrinsequement sur la variete entropique possede la propriete de conserver les discontinuites, ce qui permet de lisser les estimateurs des parametres de lois statistiques de facon anisotrope. Nous appliquons ce formalisme au lissage spatial de parametres statistiques de processus autoregressifs via la metrique de Siegel, en deduisant l’expression des operateurs agissant sur les coefficients de reflexion qui permettent de lisser anisotropiquement des spectres Doppler. Que ce soit, pour la theorie des « Espaces d’Echelle », pour la metrique de Chentsov des densites gaussiennes, ou pour les modeles AR, le modele de geometrie hyperbolique de Poincare dans le disque unite semble jouer un role central. Abstract Our problem adresses the spatial denoising of statistical parameters estimation via the geometric non-linear Laplace-Beltrami Flow based on the embedding space geometry deduced from Information geometry. Input of our problem is a map W where Σ is a ndimensional Riemannian manifold and M → Σ : X is the embedding of this manifold in a space which is hybrid space of spatial coordinates and statistical parameters coordinates (Chentsov space of Information geometry deduced from Fisher metric). Then, our problem is solved viewing parameters space of Chentsov as embedding maps, that flow toward minimal surfaces.This spatial denoising, recently introduced by N.Sochen & R. Kimmel [2] in Image processing, and presently extended for spatial statistical parameters estimation denoising preserves discontinuities (The operator has the good behaviour that the projection is edge preserving.). After the definition of the Laplace-Beltrami flow for any statistical parameters space based on Fisher metric, we provide different applications for anisotropic spatial smoothing of Gaussian law parameters and reflection coefficient in Doppler analysis. In case of Doppler analysis, the hybrid space is the Embedding Siegel space. In all cases, Poincare’s hyperbolic geometry model in unit disk seems to play a central role.
Learning to Think Outside the Box: Wide-Baseline Light Field Depth Estimation with EPI-Shift (2019)

We propose a method for depth estimation from light field data, based on a fully convolutional neural network architecture. Our goal is to design a pipeline which achieves highly accurate results for small-and wide-baseline light fields. Since light field training data is scarce, all learning-based approaches use a small receptive field and operate on small disparity ranges. In order to work with wide-baseline light fields, we introduce the idea of EPI-Shift: To virtually shift the light field stack which enables to retain a small receptive field, independent of the disparity range. In this way, our approach "learns to think outside the box of the receptive field"'. Our network performs joint classification of integer disparities and regression of disparity-offsets. A U-Net component provides excellent long-range smoothing. EPI-Shift considerably outperforms the state-of-the-art learning-based approaches and is on par with hand-crafted methods. We demonstrate this on a publicly available, synthetic, small-baseline benchmark and on large-baseline real-world recordings.
Storm rising! The Obamacare exchanges will catalyze change: why physicians need to pay attention to the weather (2018)

The Patient Protection and Affordable Care Act (ACA) of 2010, commonly known as Obamacare has had a large effect on healthcare delivery to millions of Americans.1–3 There are many elements of the ACA that could impact NeuroInterventionalists. One prominent example is the formation of independent boards with the power to unilaterally modify physician payment structures and use comparative effectiveness research to change medicine and healthcare delivery.4 5 

Additionally, the ACA established a formal framework for considering the transition from ‘volume to value-based’ healthcare through the creation of the Innovation Center.6 Among the seven broad approaches for achieving this migration, two methodologies were of particular relevance to NeuroInterventionalists; the Bundled Payment for Care Improvement Initiative and Accountable Care Organizations, with both approaches remaining active elements into the present day.7–11 Prior to passage of the ACA, the problem of Americans lacking adequate health insurance coverage (absent or insufficient) grew worse each year. In 2010, 55.3% of Americans were covered by employer-based insurance.12 The elderly and poor, as well as some additional vulnerable groups, were already covered by Medicare and Medicaid (14.5% and 15.9% 13 of the population respectively).13 Additional programs, such as the Veterans Health Administration, provided coverage to a small proportion of the population. Shockingly, by 2010, almost 50 million Americans had no form of medical insurance. The drafters of the ACA legislation considered expanding coverage to be mission-critical. Ultimately, they decided on two main strategies to achieve that goal.

The first strategy was Medicaid expansion. By increasing the number of patients eligible to receive Medicaid, many more people would obtain insurance coverage. To enable this expansion, the ACA loosened the criteria required for becoming a Medicaid beneficiary and millions of additional patients signed up for the program. Nonetheless, a large cohort of patients remained uninsured …
Bénéfices des activités physiques adaptées au cours de l'allogreffe de cellules souches hématopoïétiques : étude de faisabilité Adapted Physical Activity Program (Dance) in Adults Treated by Hematopoietic Stem Cell Transplantation: a Feasibility Study (2015)

Objectives: The aim of this study is to assess the feasibility of an Adapted Physical Activity (APA) program of dance in adults with blood cancer treated by hematopoietic stem cell transplantation (HSCT). Materials and methods: A controlled study was set up comparing 2 groups: APA and control. The subjects were adults treated by HSCT. During the intervention (dance, 3 weeks, 3 sessions per week), the following criteria were selected to study feasibility: acceptability, adherence, satisfaction, heart target rate. The comparison was based on inter-group assessment of perceived fatigue, level of anxiety and depression. Results: An adherence rate of 90.6% was noted. Perceived fatigue decreased in the APA group, but this difference was not significant after controlling for scores at baseline. Conclusion: An APA program is feasible in patients treated by HSCT.