gebhart/patrepeval huggingface dataset:
Reactions of Metal Ions at Fluorinated SAM (Self-Assembled Monolayer) Surfaces: Formation of MFn+ (M = Ti, Cr, Fe, Mo, and W; n = 1-5) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Metal Ions at Fluorinated SAM (Self-Assembled Monolayer) Surfaces: Formation of MFn+ (M = Ti, Cr, Fe, Mo, and W; n = 1-5)T. Pradeep, D. E. Riederer Jr., S. H. Hoke II, T. Ast, R. G. Cooks, and M. R. LinfordCite this: J. Am. Chem. Soc. 1994, 116, 19, 8658–8665Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00098a028https://doi.org/10.1021/ja00098a028research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal Effect in SHG of High-Power CW Lasers in Periodically Poled LiNbO3-type crystals (2016)

A model which consists of the propagation of fundamental and second harmonic waves, light-induced heating, and the heat transports is proposed to investigate the achieved output power of second-harmonic continuous-wave generation without breakdown.
Conformational and biological analysis of α-MSH fragment analogues with sterically constrained amino acid residues (1988)

Conformational and biological analysis of the linear 4-11 fragment analogues, Ac-[Nle 4 ]-α-MSH 4-11 -NH 2 ( II ) and Ac-[Nle 4 , D-Phe 7 ]-α-MSH 4-11 -NH 2 ( III ) and related analogues have been undertaken. In solution, the peptide backbone is flexible, but in the case of D-Phe 7 analogues an interaction of the His 6 , D-Phe 7 and Arg 8 amino acid side chain groups may be present based on the shielding patterns observed in the proton NMR and on comparison of N T 1 values. The importance of the position 7 to the biological and conformational properties was further examined by substitution of either L- or D-phenylglycine (Pgl) or L- and D-1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) for phenylalanine-7. Ac-[Nle 4 , Pgl 7 ]-α-MSH 4-11 -NH 2 ( IV ), Ac-[Nle 4 , D-Pgl 7 ]-α-MSH 4-11 -NH 2 ( V ), Ac-[Nle 4 , Tic 7 ]-α-MSH 4-11 -NH 2 ( VI ), and Ac-[Nle 4 , D-Tic 7 ]-α-MSH 4-11 -NH 2 ( VII ) were prepared. These substituted analogues were examined for their biological activities and conformational properties with emphasis on the three-dimensional orientation of the aromatic ring in the position 7, and the effects of the aromatic ring on adjacent amino acids, and on biological activities. The relative potencies of the analogues in the frog skin assay system were: II (1·00); III (118); IV (82·4); V (0·18); VI (0·18); and VII (0·14); and in the lizard skin bioassay they were: II (1·00); III (10·0); IV (0·14); V (0·005); VI (0·00025); and VII (0·01). On the basis of the NMR studies the L-phenylglycine substitution results in an enhanced ring stacking interaction between the phenyl ring of Pgl 7 and the indole ring of Trp 9 . The 1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) substitution leads to significant backbone restriction and an interaction of the alpha proton of His 6 with the carbonyl of Glu 5 . The possible relationships of these effects to biological activity are discussed.
Multi-objective optimisation of split-plot designs (2022)

Modern experiments allow scientists to tackle scientific problems of increasing complexity. Often experiments are characterised by factors that have levels which are harder to set than others. A possible solution is the use of a split-plot design. Many solutions are available in the literature to find optimal designs that focus solely on optimising a single criterion. Multi-criteria approaches have been developed to overcome the limitations of the one-objective optimisation, however they mainly focus on estimating the precision of the fixed factor effects, ignoring the variance component estimation. The Multi-Stratum Two-Phase Local Search (MS-TPLS) algorithm for multi-objective optimisation of designs of experiments is extended, in order to ensure pure-error estimation of the variance components. The proposed solution is applied to two motivating problems and the final optimal Pareto front and related designs are compared with other designs from the relevant literature. Experimental results show that the designs from the obtained Pareto front represent good candidate solutions based on the different objectives.
l-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats (2009)

Even though renal hypoxia is believed to play a pivotal role in the development of acute kidney injury, no study has specifically addressed the alterations in renal oxygenation in the early onset of renal ischemia-reperfusion (I/R). Renal oxygenation depends on a balance between oxygen supply and consumption, with the nitric oxide (NO) as a major regulator of microvascular oxygen supply and oxygen consumption. The aim of this study was to investigate whether I/R induces inducible NO synthase (iNOS)-dependent early changes in renal oxygenation and the potential benefit of iNOS inhibitors on such alterations. Anesthetized Sprague-Dawley rats underwent a 30-min suprarenal aortic clamping with or without either the nonselective NO synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) or the selective iNOS inhibitor L-N(6)-(1-iminoethyl)lysine hydrochloride (L-NIL). Cortical (CmicroPo(2)) and outer medullary (MmicroPo(2)) microvascular oxygen pressure (microPo(2)), renal oxygen delivery (Do(2ren)), renal oxygen consumption (Vo(2)(ren)), and renal oxygen extraction (O(2)ER) were measured by oxygen-dependent quenching phosphorescence techniques throughout 2 h of reperfusion. During reperfusion renal arterial resistance and oxygen shunting increased, whereas renal blood flow, CmicroPo(2), and MmicroPo(2) (-70, -42, and -42%, respectively, P < 0.05), Vo(2)(ren), and Do(2ren) (-70%, P < 0.0001, and -28%, P < 0.05) dropped. Whereas L-NAME further decreased Do(2ren), Vo(2)(ren), CmicroPo(2), and MmicroPo(2) and deteriorated renal function, L-NIL partially prevented the drop of Do(2ren) and microPo(2), increased O(2)ER, restored Vo(2)(ren) and metabolic efficiency, and prevented deterioration of renal function. Our results demonstrate that renal I/R induces early iNOS-dependent microvascular hypoxia in disrupting the balance between microvascular oxygen supply and Vo(2)(ren), whereas endothelial NO synthase activity is compulsory for the maintenance of this balance. L-NIL can prevent ischemic-induced renal microvascular hypoxia.
Systematic identification of edited microRNAs in the human brain (2012)

Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA) structure. Such dsRNAs are formed as part of the microRNA (miRNA) maturation process, and it is therefore expected that miRNAs are affected by A-to-I editing. Editing of miRNAs has the potential to add another layer of complexity to gene regulation pathways, especially if editing occurs within the miRNA-mRNA recognition site. Thus, it is of interest to study the extent of this phenomenon. Current reports in the literature disagree on its extent; while some reports claim that it may be widespread, others deem the reported events as rare. Utilizing a next-generation sequencing (NGS) approach supplemented by an extensive bioinformatic analysis, we were able to systematically identify A-to-I editing events in mature miRNAs derived from human brain tissues. Our algorithm successfully identified many of the known editing sites in mature miRNAs and revealed 17 novel human sites, 12 of which are in the recognition sites of the miRNAs. We confirmed most of the editing events using in vitro ADAR overexpression assays. The editing efficiency of most sites identified is very low. Similar results are obtained for publicly available data sets of mouse brain-regions tissues. Thus, we find that A-to-I editing does alter several miRNAs, but it is not widespread.
ChemInform Abstract: SrP3N5O: A Highly Condensed Layer Phosphate Structure Solved from a Nanocrystal by Automated Electron Diffraction Tomography. (2011)

Abstract The title compound is synthesized from a mixture of SrS, OP(NH 2 ) 3 , SP(NH 2 ) 3 , and NH 4 Cl (silica glass ampule, 750 °C, 72 h).
Damping parameter and interfacial perpendicular magnetic anisotropy of FeB nanopillar sandwiched between MgO barrier and cap layers in magnetic tunnel junctions (2014)

We systematically investigated the Gilbert damping (α) and interfacial perpendicular magnetic anisotropy (Ki) in magnetic tunnel junctions with a MgO-barrier/FeB/MgO-cap layered structure using the spin-torque diode effect. By increasing the MgO cap thickness, α decreased, whereas Ki increased monotonically. Values down to 0.0054 for α and up to 3.3 erg/cm2 for Ki were obtained for a MgO cap thickness of 0.6 nm. The small α and large Ki suggest that MgO-capped FeB is a suitable free layer for spintronics devices such as spin-torque oscillators and spin-torque magnetic random access memories.
Granulocyte-Macrophage and Macrophage Colony-Stimulating Factors Activate Intramacrophage Killing of Leishmania mexicana amazonensis (1990)

Leishmania organisms are important pathogens, causing diseases worldwide. Standard therapies are often toxic and are not always effective. The effect of recombinant human granulocyte-macrophage and macrophage colony-stimulating factors (GM-CSF and M-CSF) on intramacrophage survival of Leishmania mexicana amazonensis (Lma) were compared with those of interferon-gamma (IFN-gamma). Macrophages previously infected with Lma were treated with or without GM-CSF and M-CSF. Compared with no cytokine treatment, treatment with GM-CSF (0.1-100 ng/ml) or M-CSF (1:3.5 X 10(6) - 1:3.5 X 10(3) dilutions) caused a significant dose-dependent reduction in intracellular parasites, 427 +/- 20 (mean +/- SE) Lma/100 macrophages. GM-CSF or M-CSF in combination with IFN-gamma resulted in more effective inhibition of intracellular parasites. Thus, the cytostatic activity appears to require interaction between cytokines, macrophages, and amastigotes. These cytokines are potential therapeutic agents for visceral leishmaniasis.
Determination of Monoaromatic Hydrocarbons in Water Samples by Nano-Liquid Chromatography using a Composite Carbon Nanotubes- Lauryl Polymethacrylate Capillary Monolithic Column (2018)

Background: This work reports a green analytical method for the determination of organic environmental pollutants using nano-liquid chromatography with a self-made column for rapid, sensitive, inexpensive and efficient analysis of BTX pollutants in water. The applications of monolithic nanoscale columns for quantitative analysis of environmental real samples are very limited in the literature. Methods: A capillary column containing a composite of multi-walled carbon nanotubes incorporated into a lauryl methacrylate-co-ethylene dimethacrylate porous monolithic polymer was fabricated for the determination of BTX pollutants in real water samples. Results: Baseline separation was accomplished at 0.4 µL/min flow rate with UV-detection set at 208 nm. Under the optimum conditions, the calibration curves were validated over the range of 1.0-500 µg/L with R2 more than 0.9992. The detection limits of benzene, toluene, o-xylene and m/p-xylene were 0.25, 0.05, 0.075 and 0.05 µg/L, respectively. After a simple extraction process with a theoretical preconcentration factor equal to 200, the recovery values in Milli-Q, tap and sea water samples were found to be ranged from 84.85 to 97.84% with %RSD less than 7.5. Furthermore, we reported a comparison between our prepared composite column with a commercial C18 silica based column which is the most used in such analytical field. Each column demonstrated its advantages from different analytical aspects. Conclusion: The application of monolithic columns and nano-scale LC for routine analysis of environmental samples is very promising as the use of monolithic capillary columns offers several advantages over conventional scale particulate packed columns.
Fabrication of X-ray absorption gratings by centrifugal deposition of bimodal tungsten particles in high aspect ratio silicon templates (2022)

Grating-based X-ray imaging employs high aspect ratio absorption gratings to generate contrast induced by attenuating, phase-shifting, and small-angle scattering properties of the imaged object. The fabrication of the absorption gratings remains a crucial challenge of the method on its pathway to clinical applications. We explore a simple and fast centrifugal tungsten particle deposition process into silicon-etched grating templates, which has decisive advantages over conventional methods. For that, we use a bimodal tungsten particle suspension which is introduced into a custom designed grating holder and centrifuged at over 1000×g. Gratings with 45 µm period, 450 µm depth, and 170 mm × 38 mm active area are successfully processed reaching a homogeneous absorber filling. The effective absorbing tungsten thickness in the trenches is 207 µm resulting in a filling ratio of 46.6% compared to a voidless filling. The grating was tested in a Talbot-Lau interferometer designed for clinical X-ray dark-field computed tomography, where visibilities up to 33.6% at 60 kV were achieved.
Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity (2008)

Reactive microglial cells may exacerbate the pathology in some neurodegenerative disorders. Supernatants of stimulated human microglial cells, or their surrogate THP-1 cells, are lethal to cultured human neuroblastoma SH-SY5Y cells. To explore this neurotoxicity, we examined the spectrum of proteins generated by THP-1 cells using the technique of stable isotope labeling by amino acids in cell culture (SILAC). Unstimulated cells were grown in medium with light L-[(12)C(6)] arginine while cells stimulated by lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) were grown in medium with heavy L-[(13)C(6)] arginine. Proteins isolated from the media were digested with trypsin, and relative concentrations of generated peptides determined by mass spectrometry. More than 1,500 proteins or putative proteins were identified. Of these, 174 were increased and 189 decreased by more than twofold in the stimulated cell supernatant. We selected one upregulated protein, prolyl endopeptidase (PEP), for further investigation of its potential contribution to neurotoxicity. We first confirmed its upregulation by comparing its enzymatic activity in stimulated and unstimulated cell supernatants. We then evaluated two specific PEP inhibitors, Boc-Asn-Phe-Pro-aldehyde and Z-Pro-Pro-aldehyde-dimethyl acetal, for their potential to reduce toxicity of stimulated THP-1 cell and human microglia supernatants towards SH-SY5Y cells. We found both to be partially protective in a concentration-dependent manner. Inhibition of PEP may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases.
Piezoresistive cantilever probes for simultaneous nanoscale topography and conductivity imaging (2013)

In this paper, we present the design and fabrication of piezoresistive Microwave Impedance Microscopy (MIM) cantilever probes integrated with low impedance, electrically-shielded sharp tips to enable simultaneous topographical and electrical scanning probe microscopy. The fabricated probes show a piezoresistive resolution of 2 nm in 1 Hz to 10 kHz bandwidth, which ensures high quality topographic sensing. The resistance of the center conductor is measured less than 5 Ω and the capacitance between the conductor and shield is 1.7 pF. These parameters are critical for high sensitivity MIM imaging. Piezoresistive topography and MIM images are simultaneously obtained with the fabricated probes at room temperature and cryogenic temperature. These new piezoresistive probes improve MIM capabilities and therefore broaden MIM application in scientific and engineering areas.
The Contribution of Frameshift Translation to the Generation of Novel Human Proteins (2007)

Abstract The creation of novel proteins is not simply ascribed to duplication of homologous sequences, but can be largely explained by frameshift translation. A deficiency of the TpA dinucleotide in protein‐coding deoxyribonucleic acid (DNA) sequences renders them tolerant of frameshift mutations by minimizing the opportunity for premature stop codons, and involvement of both strands can increase genomic complexity. This supports the suggestion that new coding sequences evolve from existing or ancestral exons rather than from nonexonic sequences.
TGFBI expression is an independent predictor of survival in adjuvant-treated lung squamous cell carcinoma patients (2014)

TGFBI may be useful for the identification of a subset of NSCLC who may benefit from adjuvant therapy.
Increased Metabolic Flexibility and Complexity in a Long-Lived Growth Hormone Insensitive Mouse Model (2013)

The goal of this study was to test whether the "loss of the complexity" hypothesis can be applied to compare the metabolic patterns of mouse models with known differences in metabolic and endocrine function as well as life span. Here, we compare the complexity of locomotor activity and metabolic patterns (energy expenditure, VO₂, and respiratory quotient) of the long-lived growth hormone receptor gene deleted mice (GHR(-/-)) and their wild-type littermates. Using approximate entropy as a measure of complexity, we observed greater metabolic complexity, as indicated by greater irregularity in the physiological fluctuations of the GHR(-/-) mice. Further analysis of the data also revealed lower energy costs of locomotor activity and a stronger relationship between locomotor activity and respiratory quotient in the GHR(-/-) mice relative to controls. These findings suggest underlying differences in metabolic modulation in the GHR(-/-) mice revealed especially through measures of complexity of their time-dependent fluctuations.
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (2023)

Correction to: Nature Published online 5 February 2020 In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper. The original Article has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional minor corrections to affiliations have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper. An additional affiliation has been added for Husen M. Umer (Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden). The affiliation for Erik Larsson has been changed from Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA to Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Routes to mitomycins. Application of iminium salts to the synthesis of naphthoquinone mitosene analogs (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRoutes to mitomycins. Application of iminium salts to the synthesis of naphthoquinone mitosene analogsStephen N. Falling and Henry RapoportCite this: J. Org. Chem. 1980, 45, 7, 1260–1270Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jo01295a020https://doi.org/10.1021/jo01295a020research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterizing the Effects of Ionospheric Divergence and Decorrelation on LAAS (2000)

In the Local Area Augmentation System (LAAS), as well
as other local area DGPS systems which use single-
frequency (L1) measurements only, differential ranging
error due to the ionosphere is the result of two effects: the
temporal divergence of the code and carrier and spatial
decorrelation of delay. The effect of divergence is most
significant when ground and air filter implementations are
different; but even when filter implementations are
identical, transient differential error can exist due to the
different filter start times. The effect of spatial
decorrelation is caused by variations in the delay between
the ionospheric pierce points for the aircraft and the
ground receiver. The effective separation between ground
and aircraft antennas that defines pierce point separation
is larger than the physical separation of the two antennas
by an amount proportional to the filter time constant and
the horizontal velocity of the aircraft. In this work, both
ionospheric spatial decorrelation and divergence are
analyzed with the goal of defining conditions for safe
interoperability of ground and airborne systems.