gebhart/patrepeval huggingface dataset:
Analysis of recurrent germline mutations in theMEN1 gene encountered in apparently unrelated families (1998)

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder that manifests as varying combinations of tumors of endocrine and other tissues (parathyroids, pancreatic islets, duodenal endocrine cells, the anterior pituitary and others). The MEN1 gene is on chromosome 11q13; it was recently identified by positional cloning. We previously reported 32 different germline mutations in 47 of the 50 familial MEN1 probands studied at the NIH. Eight different germline MEN1 mutations were encountered repeatedly in two or more apparently unrelated families. We analyzed the haplotypes of families with recurrent MEN1 mutations with seven polymorphic markers in the 11q13 region surrounding the MEN1 gene (from D11S1883 to D11S4908). Disease haplotypes were inferred from germline DNA and also from tumors with 11ql3 loss of heterozygosity. Two different disease haplotype cores were shared by apparently unrelated families for two mutations in exon 2 (five families with 416delC and six families with 512delC). These two repeat mutations were associated with the two founder effects that we reported in a prior haplotype analysis. The disease haplotypes for each of the other six repeat mutations (seen twice each) were discordant, suggesting independent origins of these recurrent mutations. Most of the MEN1 germline mutations including all of those recurring independently occur in regions of CpG/CpNpG, short DNA repeats or single nucleotide repeat motifs. In conclusion, recurring germline mutations account for about half of the mutations in North American MEN1 families. They result from either founder effects or independent occurrence of one mutation more than one time.
Combinatorial synthesis of Co∕Pd magnetic multilayers (2006)

A combinatorial approach to the synthesis of high anisotropy Co∕Pd magnetic multilayer thin films is explored. Combinatorial libraries of Co∕Pd multilayer thin films were prepared using magnetron sputtering where the thicknesses of Co and Pd layers in the bilayer stack are varied. Application of multivariate regression and neural network models to the analysis of Co∕Pd multilayer combinatorial libraries is studied and the predictive capabilities of the two models are compared. The influences of the thicknesses of Co and Pd layers on magnetic properties are investigated. The models are used to design Co∕Pd multilayers with the desired magnetic properties. It is found that the neural network model enables higher accuracy than the multivariate analysis model and that the inverse design problem produces results within a good degree of precisions.
Credentials Provisioning and Management via EAP (EAP-CREDS) (2019)

With the increase number of devices, protocols, and applications that
rely on strong credentials (e.g., digital certificates, keys, or
tokens) for network access, the need for a standardized credentials
provisioning and management framework is paramount. The 802.1x
architecture allows for entities (e.g., devices, applications, etc.)
to authenticate to the network by providing a communication channel
where different methods can be used to exchange different types of
credentials. However, the need for managing these credentials (i.e.,
provisioning and renewal) is still a hard problem to solve. EAP-CREDS,
if implemented in Managed Networks (e.g., Cable Modems), could enable
our operators to offer a registration and credentials management
service integrated in the home WiFi thus enabling visibility about
registered devices. During initialization, EAP- CREDS also allows for
MUD files or URLs to be transferred between the EAP Peer and the EAP
Server, thus giving detailed visibility about devices when they are
provisioned with credentials for accessing the networks. The
possibility provided by EAP-CREDS can help to secure home or business
networks by leveraging the synergies of the security teams from the
network operators thanks to the extended knowledge of what and how is
registered/authenticated. This specifications define how to support
the provisioning and management of authentication credentials that can
be exploited in different environments (e.g., Wired, WiFi, cellular,
etc.) to users and/or devices by using EAP together with standard
provisioning protocols.
Describing Buildings by 3-Dimensional Details Found in Aerial Photography (2010)

A description of Real Properties is of interest in connection with Location-Based Services and urban resource management. The advent of Internet-maps and location aware Web-search inspires the development of such descriptions to be developed automatically and at very little incremental cost from aerial photography and its associated data products. Very important on each real property are its buildings. We describe how one can recognize and reconstruct buildings in 3 dimensions with the purpose of extracting the building size, its footprint, the number of floors, the roof shapes, the number of windows, the existence or absence of balconies. A key to success in this task is the availability of aerial photography at a greater overlap than has been customary in traditional photogrammetry, as well as a Ground Sampling Distance GSD exceeding the traditional values. We use images at a pixel size of 10 cm and with an overlap of 80% in the direction of flight and 60% across the flight direction. Such data support a robust determination of the number of floors and windows. Initial tests with data from the core of the City of Graz (Austria) produced an accuracy of 90% regarding the count of the number of floors and an accuracy of 87% regarding the detection of windows.
TESTOSTERONE INDUCED HYPOTHALAMIC MASCULINIZATION OF FEMALE RATS IS PREVENTED BY ESTRADIOL AND IS AUGMENTED DIHYDROTESTOSTERONE. (1979)

Journal Article TESTOSTERONE INDUCED HYPOTHALAMIC MASCULINIZATION OF FEMALE RATS IS PREVENTED BY ESTRADIOL AND IS AUGMENTED DIHYDROTESTOSTERONE Get access K-D Döhler, K-D Döhler Institut für Physiologische Chemie, Tierärztliche Hochschule, and Abteilung Klinische Endokrinologib, Medizinische Hochschule, D-3000 Hannover, FRG Search for other works by this author on: Oxford Academic Google Scholar J L Hancke J L Hancke Institut für Physiologische Chemie, Tierärztliche Hochschule, and Abteilung Klinische Endokrinologib, Medizinische Hochschule, D-3000 Hannover, FRG Search for other works by this author on: Oxford Academic Google Scholar Acta Endocrinologica (Norway), Volume 92, Issue 2_Supplement_b, Aug 1979, Pages S245–S253, https://doi.org/10.1530/acta.0.091S245 Published: 01 August 1979
Nonlinear sampling (2014)

In this chapter we depart from the linear sampling model treated until now and consider recovering signals that lie in a subspace, from their nonlinear samples. Surprisingly, we will see that many types of nonlinearities that are encountered in practice can be completely compensated for without having to increase the sampling rate. Thus, even though typically nonlinearities result in bandwidth expansion, using the algorithms discussed in this chapter we will be able to recover an input from its nonlinear samples at the rate associated with the input space.
DINOMO: An Elastic, Scalable, High-Performance Key-Value Store for Disaggregated Persistent Memory (Extended Version) (2022)

We present Dinomo, a novel key-value store for disaggregated persistent memory (DPM). Dinomo is the first key-value store for DPM that simultaneously achieves high common-case performance, scalability, and lightweight online reconfiguration. We observe that previously proposed key-value stores for DPM had architectural limitations that prevent them from achieving all three goals simultaneously. Dinomo uses a novel combination of techniques such as ownership partitioning, disaggregated adaptive caching, selective replication, and lock-free and log-free indexing to achieve these goals. Compared to a state-of-the-art DPM key-value store, Dinomo achieves at least 3.8x better throughput on various workloads at scale and higher scalability, while providing fast reconfiguration.
Distributed approximation of capacitated dominating sets (2007)

We study local, distributed algorithms for the capacitated minimum dominating set (CapMDS) problem, which arises in various distributed network applications. Given a network graph G = (V,E), and a capacity cap(v) ∈ N for each node v ∈ V , the CapMDS problem asks for a subset S ⊆ V of minimal cardinality, such that every network node not in S is covered by at least one neighbor in S, and every node v ∈ S covers at most cap(v) of its neighbors. We prove that in general graphs and even with uniform capacities, the problem is inherently non-local, i.e., every distributed algorithm achieving a non-trivial approximation ratio must have a time complexity that essentially grows linearly with the network diameter. On the other hand, if for some parameter ε > 0, capacities can be violated by a factor of 1 + ε, CapMDS becomes much more local. Particularly, based on a novel distributed randomized rounding technique, we present a distributed bi-criteria algorithm that achieves an O(log Δ)-approximation in time O(log3n + log(n)/ε), where n and Δ denote the number of nodes and the maximal degree in G, respectively. Finally, we prove that in geometric network graphs typically arising in wireless settings, the uniform problem can be approximated within a constant factor in logarithmic time, whereas the non-uniform problem remains entirely non-local.
Magnetic-field-dependent plasma composition of a pulsed arc in a high-vacuum ambient (2000)

The effect of a magnetic field on the plasma composition of a pulsed Au plasma stream in a high-vacuum ambient is described. The plasma was formed with a pulsed vacuum-arc-plasma source, and the time-resolved plasma composition was measured with time-of-flight charge-to-mass spectrometry. Plasma impurities due to ionization of nonmetallic species (H+, O+, and N+) were found to be below the detection limit in the absence of a magnetic field. However, in the presence of a magnetic field (0.4 T), the contribution of ionized nonmetal species to the plasma composition was up to 0.22 atomic ratio. These results are characteristic of plasma-based techniques where magnetic fields are employed in a high-vacuum ambient. In effect, the impurity incorporation during thin-film growth pertains to the present findings.
<title>Nanometer x-ray lithography</title> (1999)

New developments for x-ray nanomachining include pattern transfer onto non-planar surfaces coated with electrodeposited resists using synchrotron radiation x-rays through extremely high-resolution mask made by chemically assisted focused ion beam lithography. Standard UV photolithographic processes cannot maintain sub-micron definitions over large variation in feature topography. The ability of x-ray printing to pattern thin or thick layers of photoresist with high resolution on non-planar surfaces of large and complex topographies with limited diffraction and scattering effects and no substrate reflection is known and can be exploited for patterning microsystems with non-planar 3D geometries as well as multisided and multilayered substrates. Thin conformal coatings of electro-deposited positive and negative tone photoresist have been shown to be x-ray sensitive and accommodate sub-micro pattern transfer over surface of extreme topographical variations. Chemically assisted focused ion beam selective anisotropic erosion was used to fabricate x-ray masks directly. Masks with feature sizes less than 20 nm through 7 microns of gold were made on bulk silicon substrates and x-ray mask membranes. The technique is also applicable to other high density materials. Such masks enable the primary and secondary patterning and/or 3D machining of Nano-Electro-Mechanical Systems over large depths or complex relief and the patterning of large surface areas with sub-optically dimensioned features.
Privacy in machine-to-machine communications A state-of-the-art survey (2012)

With the rapid deployment of M2M services, countless smart “things” with sensing and communication capabilities are collecting data about the physical world we live in. These data can be used by various service providers to make their services more customized with high quality. On the other hand the availability of personal information raises serious concerns over individual privacy. In order to prevent unauthorized identification, localization and tracking of humans and things, privacy preserving mechanisms must be an integral part of M2M based systems. This survey gives an overview of existing approaches to information privacy, focusing on technical solutions.
The first stable high silica zeolite with extra-large 24-ring channels (2013)

Electron crystallography has evolved as a powerful method for structural characterization of a wide range of materials. It has two significant advantages over other methods for structure determination, e.g. X-ray diffraction. Electrons interact much more strongly with matter compared to X-rays and they can be focused by electromagnetic lenses to form images with atomic resolution. These advantages make electron crystallography a unique tool for characterization of crystalline materials suffering from small crystal size and complex or disordered structures. Zeolites are a class of microporous materials with significance in several applications. They often possess complex and disordered structures, which demand large efforts in the structure determination. Over the last years, two new electron crystallographic methods have been developed; the rotation electron diffraction (RED) and the structure projection reconstruction from a through-focus series of high resolution transmission electron microscopy (HRTEM) images. In this thesis, they will be applied for structure determination of four new zeolite structures, including EMM-25 and EMM-23 with two ordered structures, and ITQ-39 and ITQ-38 with disordered structures. Each of the structure solutions have different challenges to overcome. The high silica borosilicate EMM-25 was solved by the RED method. The aluminosilicate EMM-23 was solved by a combination of HRTEM and RED. The structure solution of two materials with disordered structures, ITQ-39 and ITQ-38, will be described. For materials containing disorders, structure projection images are of utmost importance. Furthermore, the mesoporosity inside hierarchically porous ZSM-5 crystals was studied by a combination of focused ion beam (FIB) and HRTEM imaging. The last part of this thesis explores STEM imaging for use in structure determination from 3D reconstruction.
Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. (1997)

Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila embryogenesis, is regulated by Hemipterous (Hep) and Basket (Bsk), homologs of JNKK and JNK, respectively. Embryos lacking Jun activity exhibit a dorsal closure phenotype, very similar to that of bsk and hep mutants, indicating that Jun is a target of Hep/Bsk signaling. In eye and wing development Jun participates in a separate signaling pathway that is comprised of Ras, Raf, and the ERK-type kinase Rolled. In contrast to the strict requirement for Jun in dorsal closure, its role in the eye is redundant but can be uncovered by mutations in other signaling components. The redundant function of Jun in eye development may contribute to the precision of photoreceptor differentiation and ommatidial assembly.
Spatio-energetic cross-talk in photon counting detectors: N×N binning and sub-pixel masking (2018)

Smaller pixels sizes of x-ray photon counting detectors (PCDs) have the two conflicting effects as follows. On one hand, smaller pixel sizes improve the ability to handle high count rates of x-rays (i.e., pulse pileups) because incident rates onto each PCD pixel decreases with decreasing the size. On the other hand, smaller pixel sizes increase chances of crosstalk and double-counting (or n-tuple-counting in general) between neighboring pixels, because, while the same size of electron charge cloud generated by a photon is independent of PCD sizes, the charge cloud size relative to the PCD size increases with decreasing the PCD size. In addition, the following two aspects are practical configurations in actual PCD computed tomography systems: N&times;N-pixel binning and anti-scatter grids. When n-tuple-counting occurs and those data are binned/added during post-acquisition process, the variance of the data will be larger than its mean. The anti-scatter grids may eliminate or decrease the cross-talk and n-tuple-counting by blocking primary x-rays near pixel boundaries or for the width of one pixel entirely. In this study, we studied the effects of PCD pixel sizes, N&times;N-pixel binning, and pixel masking on soft tissue contrast visibility using newly developed Photon Counting Toolkit (PcTK version 3.2; https://pctk.jhu.edu).
Laminate package trends for high-speed system interconnects (2003)

As the performance of processors and their associated supporting components increases with improvements in process technologies, the demand on packaging solutions is also increasing. High-speed devices require complex thermal, power delivery and signal integrity solutions at relatively low cost to be competitive in the present marketplace. This paper presents the rapidly evolving laminate package trends and advances for high-speed system-level interconnects. The importance of properly designing the substrate for high-speed signaling is discussed including identification of key parameters and design tradeoffs.
American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies – Secondary Publication (2020)

ABSTRACT Cell‐based therapies, defined here as the delivery of cells in vivo to treat disease, have recently gained increasing public attention as a potentially promising approach to restore structure and function to musculoskeletal tissues. Although cell‐based therapy has the potential to improve the treatment of disorders of the musculoskeletal system, there is also the possibility of misuse and misrepresentation of the efficacy of such treatments. The medical literature contains anecdotal reports and research studies, along with web‐based marketing and patient testimonials supporting cell‐based therapy. Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are committed to ensuring that the potential of cell‐based therapies is realized through rigorous, reproducible, and clinically meaningful scientific discovery. The two organizations convened a multidisciplinary and international Task Force composed of physicians, surgeons, and scientists who are recognized experts in the development and use of cell‐based therapies. The Task Force was charged with defining the state‐of‐the art in cell‐based therapies and identifying the gaps in knowledge and methodologies that should guide the research agenda. The efforts of this Task Force are designed to provide researchers and clinicians with a better understanding of the current state of the science and research needed to advance the study and use of cell‐based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols will be critical to leveraging these innovative treatments and optimizing clinical and functional patient outcomes. In addition to providing specific recommendations and ethical considerations for preclinical and clinical investigations, this report concludes with an outline to address knowledge gaps in how to determine the cell autonomous and nonautonomous effects of a donor population used for bone regeneration. © 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:485–502, 2020
Metric engineering of supramolecular borromean rings (2005)

info:eu-repo/semantics/published
Structure in Thin and Ultrathin Spin-Cast Polymer Films (1996)

The molecular organization in ultrathin polymer films (thicknesses less than 1000 angstroms) and thin polymer films (thicknesses between 1000 and 10,000 angstroms) may differ substantially from that of bulk polymers, which can lead to important differences in resulting thermophysical properties. Such constrained geometry films have been fabricated from amorphous poly(3-methyl-4-hydroxy styrene) (PMHS) and semicrystalline poly(di-n-hexyl silane) (PD6S) by means of spin-casting. The residual solvent content is substantially greater in ultrathin PMHS films, which suggests a higher glass transition temperature that results from a stronger hydrogen-bonded network as compared with that in thicker films. Crystallization of PD6S is substantially hindered in ultrathin films, in which a critical thickness of 150 angstroms is needed for crystalline morphology to exist and in which the rate of crystallization is initially slow but increases rapidly as the film approaches 500 angstroms in thickness.
Aplicando Model-Driven Development à Plataforma GPGPU (2009)

GPUs (Graphics Processing Units) são dispositivos gráficos que vêm ganhando destaque nos últimos anos pela sua eficiência em processamento paralelo. Neste contexto, o termo GPGPU (General-Purpose computation on GPU) é um novo conceito que visa explorar as vantagens das GPUs em áreas não necessariamente relacionadas a processamento gráfico. Este trabalho aplica princípios do MDD (Model-Driven Development) ao desenvolvimento de aplicações para GPU, visando produzir um ambiente mais adequado para a construção desse tipo de software. O resultado do trabalho foi o desenvolvimento de uma ferramenta que enxerga uma aplicação como um modelo e gera automaticamente parte significativa do código desta aplicação. O código gerado é expresso na linguagem definida por CUDA (Compute Unified Device Architecture), uma plataforma de programação para GPGPU.
Ciprokiren (Ro 44-9375). A renin inhibitor with increasing effects on chronic treatment. (1994)

The present study characterizes the new transition-state renin inhibitor ciprokiren (Ro 44-9375) in squirrel monkeys. Arterial blood pressure was monitored by telemetry in freely moving, chronically instrumented conscious animals. In vitro at pH 7.4, ciprokiren inhibited human renin in buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. It was equipotent against primate plasma renin and also inhibited plasma renin from dog and guinea pig in the nanomolar range (IC50, 29 and 65 nmol/L, respectively). After acute oral administration it reduced arterial blood pressure dose dependently in normotensive sodium-depleted and cyclosporin-induced hypertensive squirrel monkeys, starting with the minimal oral dose of 3 micrograms/kg. Daily oral doses of 1 microgram/kg showed a progressive blood pressure decrease, with a maximal response reached after 1 week. The drug could also be applied transdermally with similar hemodynamic effects without any decrease of plasma renin activity or plasma immunoreactive angiotensin II. Thus, ciprokiren is characterized in squirrel monkeys as a renin inhibitor with high in vivo potency that might act mainly in the tissular compartment.
ChemInform Abstract: A Simple and Efficient New Glycal Synthesis. (1989)

Abstract Reaction of the O‐isopropylidenefuranosyl halides (I) and (VII) with potassium graphite laminate (II) leads to the formation of the furanosyl potassium salts (III) and (VIII) from which the glycals (IV) and (IX) are obtained upon aqueous work‐up.