gebhart/patrepeval huggingface dataset:
Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii (2006)

The nucleus tractus solitarii (NTS) is the first site of integration for primary baroreceptor afferents, which release glutamate to excite second-order neurones through ionotropic receptors. In vitro studies indicate that glutamate may also activate metabotropic receptors (mGluRs) to modulate the excitability of NTS neurones at pre- and postsynaptic loci. We examined the functional role of metabotropic glutamate receptors (mGluRs) in modulating the baroreceptor reflex in the rat NTS. Using the working heart-brainstem preparation, the baroreflex was activated using brief pressor stimuli and the consequent cardiac (heart rate change) and non-cardiac sympathetic (T8-10 chain) baroreflex gains were obtained. Microinjections of glutamate antagonists were made bilaterally into the NTS at the site of termination of baroreceptor afferents. NTS microinjection of kynurenate (ionotropic antagonist) inhibited both the cardiac and sympathetic baroreflex gains (16 +/- 5% and 59 +/- 11% of control, respectively). The non-selective mGluR antagonist MCPG produced a dose-dependent inhibition of the cardiac gain (30 +/- 3% of control) but not the sympathetic gain. Selective inhibitions of the cardiac gain were also seen with LY341495 and EGLU suggesting the response was mediated by group II mGluRs. This effect on cardiac gain involves attenuation of the parasympathetic baroreflex as it persists in the presence of atenolol. Prior NTS microinjection of bicuculline (GABA(A) antagonist) prevented the mGluR-mediated attenuation of the cardiac gain. These results are consistent with the reported presynaptic inhibition of GABAergic transmission by group II mGluRs in the NTS and constitute a plausible mechanism allowing selective feed-forward disinhibition to increase the gain of the cardiac limb of the baroreflex without changing the sympathoinhibitory component.
Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines (1992)

Systemic and pulmonary vascular responses to pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide with 68% sequence homology to vasoactive intestinal peptide (VIP), were investigated in the anesthetized cat. Intravenous injections of PACAP in doses of 0.1-3.0 nmol/kg produced decreases in arterial pressure (AP) at low doses and biphasic changes (decreases followed by increases) at higher doses, which were accompanied by increases in central venous pressure (CVP) and cardiac output (CO), and decreases and biphasic changes in systemic vascular resistance (SVR). In contrast, VIP in doses of 0.1-3.0 nmol/kg produced only dose-dependent decreases in AP and SVR and produced little change in CVP and CO. PACAP produced increased pulmonary arterial pressure (PAP), left atrial pressure (LAP), and increases in pulmonary vascular resistance (PVR). PACAP increased heart rate (HR) and right ventricular contractile force (RVCF), while VIP had no effect. Increases in AP and SVR in response to PACAP were changed to decreases following the administration of phentolamine or after adrenalectomy. Under constant flow conditions, PACAP and VIP produced dose-dependent decreases in lobar arterial pressure when tone was elevated, with PACAP being threefold more potent than VIP. Meclofenamate and nitro-L-arginine methyl ester (L-NAME) had no effect on pulmonary responses to the peptides. PACAP produced dose-dependent biphasic changes in hindquarters perfusion pressure, whereas VIP produced only decreases that were unchanged by indomethacin, L-NAME, and glibenclamide. Phentolamine and adrenalectomy eliminated the hindquarters pressor response to PACAP and D-Phe2-VIP, a VIP antagonist, reduced responses to VIP but not to PACAP. These data suggest that responses to PACAP and VIP are mediated by distinct receptors and that pressor responses to PACAP are due to the release of catecholamines from the adrenal gland.
Nanosession: 2D Electron Systems ‐ Correlation Effects and Transport (2012)

This chapter discusses the two-dimensional electron gas (2DEG) at the vacuum-cleaved surface of KTaO3 (KTO). The surfaces and interfaces of SrTiO3 have attracted intense interest in many fields ranging from solidstate physics to surface chemistry and oxide electronics. The chapter also discusses the scanning tunneling microscopy (STM) and density functional theory (DFT) calculations study of the SrTiO3(110) surface. In spite of many years of intensive researches, there are still many open questions concerning the properties of the LaAlO3 (LAO)/SrTiO3 (STO) n-type interface which, beyond a critical LAO thickness,exhibits a confined distribution of charge carriers at the interface. Based on first-principles density functional calculations, the chapter addresses the origin of the ferromagnetic phase and investigate the nature of the electronic states at the interface of ideal defect-free (001) LAO/STO heterostructures. Oxide interfaces have shown a variety of intriguing phenomena such as metallic conduction between band insulators, interface magnetism, and interface superconductivity. Controlled Vocabulary Terms band theory; density functional theory; scanning tunnelling microscopy; two-dimensional electron gas
X-cut LiNbO3 Coupled Resonators for Narrow-band Filtering Applications (2020)

This paper reports the first implementation of a narrow-band filter exploiting two electrically coupled high performance X-cut Lithium Niobate (LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> or LN) Laterally Vibrating Resonators (LVRs) operating around 108 MHz. By selecting the proper coupling capacitance at the common node, the series of identical resonators attains a bandpass response with insertion loss of 2.8 dB and an average return loss of 10 dB in 300 kHz with 50 Ω terminations. The group delay is approximately 1.8 μs and it varies less than 7% inside a 0.09% fractional bandwidth (BW%). The out-of-band rejection is > 60 dB and the 20dB-shape factor is 2.33. This filter topology is a perfect candidate for spectral sensing and interferes removal in new Radio Frequency (RF) modules, as the channel selective filter exhibits low losses and narrow-band response combined with constant group delay and high rejection, within a simple 2-mask process fabrication and small form factor. The overall performances can be further improved through a monolithic integration of the filter, drastically reducing the impact of parasitics coming from the test board. Simulated and measured results are shown along with an even-odd mathematical analysis.
Imprinting of fine-scale magnetic patterns in electroplated hard magnetic films using magnetic foil masks (2014)

This paper presents a batch-fabrication approach to imprint complex magnetic pole patterns (perpendicular north/south poles) into hard magnetic films using fine-scale, laser-machined iron foil “masks.” In this approach, pulsed magnetic fields varying between 0.1 and 1.0 T are used in conjunction with the field-concentrating effect of the iron foil masks to selectively reverse the magnetization of selected regions of 10-μm-thick Co80Pt20 films (Br = 1 T, Hci = 340 kA/m). Simple stripe array patterns are systematically studied both experimentally and via simulation, achieving patterned feature sizes (poles) down to 30 μm. Double exposures are also explored to create checkerboard patterns from simple stripe-like masks. Finally, masks with more complex patterns are used to demonstrate the viability of the approach to imprint arbitrary features.
Abstract 963: Epigenetic silencing of cancer-specific methylation may converge on therapeutic targets on human cancers (2012)

Abstract (Background) We have identified numerous candidate tumor suppressor genes (TSGs) which are inactivated by cancer-specific CpG island methylation. We reviewed differential patterns of cancer-specific methylation in esophageal squamous cell carcinoma, gastric adenocarcinoma, and colorectal adenocarcinoma. (Matherials and Methods) A modified pharmacological unmasking microarray in combination with tissue expression patterns identified novel cancer-specific methylation in each organ site, and we tabulated methylation frequency for each type of cancer. (Results) (1) In esophageal squamous cell carcinoma, we discovered cancer-specific methylation for NEFH (84%), NMDAR2B (78%), DCC (74%), cyclin A1 (60%), CRBP1 (52%), HOPX (50%), trypsinogen-4 (50%), and PGP9.5 (42%). (2) In gastric adenocarcinoma, we validated cancer-specific methylation for HOPX (87%), Reprimo (78%), PGP9.5 (70%), NMDAR2B (70%), and RIZ1 (40%). (3) In colorectal adenocarcinoma, we identified cancer-specific methylation for Beta 4 GalT1 (82%), Oncostatin MR (80%), DFNA5 (65%), LIFR (65%), and HOPX (52%). (4) From our estimates, about 300 genes were frequently methylated specifically in cancer tissues, and among them, and around 70% of these genes were upstream or downstream of the p53 pathway (NMDAR2AB, DCC, cyclin A1, PGP9.5, HOPX, Reprimo, DFNA5). Apoptotic pathways other than those in the p53 pathway, including death receptor signaling was also observed. Another 30% of methylated genes antagonize unique oncogenic pathways in individual cancers. Either NEFH or HOPX was involved in inactivation of pAkt through an unknown mechanism or PTEN induction in ESCC. RIZ1 uniquely inactivated in gastric cancer, is an inhibitor of the IGF receptor pathway. Oncostatin M R or LIFR in CRC are inhibitors of pStat3. All inactivated TSG candidates were demonstrated to be robustly reactivated by de-methylating agents. (Conclusion) In GI cancers, numerous genes involved in p53 activation are commonly suppressed in expression, and epigenetic reversion of p53 activity may be beneficial for killing cancer cells more efficiently. Moreover, unique oncogenic inhibitors will need to be developed for specific targets in similar but related pathways for varied organ sites. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 963. doi:1538-7445.AM2012-963
ChemInform Abstract: CHARACTERIZATION OF CHLOROCLOSOBORANE ACIDS AS ELECTROLYTES FOR ACID FUEL CELLS (1985)

Abstract H2B"C1" und HzßmCllo werden durch Ionenaustausch oder Elektrolyse durch eine Nation 125‐Membran aus den entsprechenden handelsüblichen Li‐Salzen in hochreiner Form dargestellt (Entwicklung von Reinigungprozeduren) und durch IR‐, Elektronen‐, N MR‐ und Massenspektren charakterisiert.
Photonic device fabrication in glass by use of nonlinear materials processing with a femtosecond laser oscillator (2001)

Single-mode X couplers and three-dimensional waveguides are fabricated in transparent glasses by use of an unamplified femtosecond laser generating energies of up to 100 nJ. Changing fabrication parameters such as power and scanning speed permits creation of waveguides with a wide range of structures and refractive-index difference. Optical coherence tomography shows large refractive-index changes of up to ∼10-2 in the waveguides; these changes are consistent with guided mode analysis.
User body effects on mobile antennas and wireless systems of 5G communication (2020)

User body effects on mobile antennas and wireless systems for the fifth-generation (5G) mobile network are analyzed in this paper. Effects on different antenna technologies in mobile handsets include single antenna systems, multiple antenna systems, and the antenna arrays are discussed with simulations and measurements. The corresponding impacts on wireless networks are studied as well with raytracing simulations. Several technologies on mitigating user body effects have also been provided.
Polycystic kidney disease: genes, prevalence and diagnosis (2013)

Polycystic kidney diseases (PKDs) are a group of genetic diseases that result in bilateral fluid-filled renal cysts. The cysts destroy renal parenchyma, which inevitably results in a decline of renal function. In 2009, 4.8% of patients in the USA progressing to end-stage renal disease were diagnosed with cystic kidney disease [1]. Most common among this group of diseases are the autosomal dominant PKD and autosomal recessive PKD. Additionally, PKD is a common feature in a number of rare syndromes. In this chapter, an overview of the genes and proteins involved in PKD is given. Furthermore, clinical diagnostic criteria are outlined.
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer (2021)

Numerous mechanisms of resistance arise in response to treatment with second-generation androgen receptor (AR) pathway inhibitors in metastatic castration-resistant prostate cancer (mCRPC). Among these, point mutations in the ligand binding domain can transform antagonists into agonists, driving the disease through activation of AR signaling. To address this unmet need, we report the discovery of JNJ-63576253, a next-generation AR pathway inhibitor that potently abrogates AR signaling in models of human prostate adenocarcinoma. JNJ-63576253 is advancing as a clinical candidate with potential effectiveness in the subset of patients who do not respond to or are progressing while on second-generation AR-targeted therapeutics.
Open systems in TLA (1994)

Article Open systems in TLA Share on Authors: Martín Abadi Digital Equipment Corporation, Systems Research Center Digital Equipment Corporation, Systems Research CenterView Profile , Leslie Lamport Digital Equipment Corporation, Systems Research Center Digital Equipment Corporation, Systems Research CenterView Profile Authors Info & Claims PODC '94: Proceedings of the thirteenth annual ACM symposium on Principles of distributed computingAugust 1994 Pages 81–90https://doi.org/10.1145/197917.197960Online:14 August 1994Publication History 12citation270DownloadsMetricsTotal Citations12Total Downloads270Last 12 Months11Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
High performance, rapid thermal/UV curing epoxy resin for additive manufacturing of short and continuous carbon fiber epoxy composites (2023)

An additive manufacturing resin system includes a container; a build platform in the container; a build platform drive; an additive manufacturing resin that forms an additive manufacturing resin bath; an additive manufacturing print head; a build material supply connected to the additive manufacturing print head; an infill resin in the container, wherein the infill resin is supported by the additive manufacturing resin bath; a computer controller; and an extruded material that forms the product, wherein the infill resin at least partially surrounds the extruded material that forms the product. An infill resin supply provides the infill resin into the container and a control valve is connected to the infill resin supply. An IR light sensor is connected to the control valve and operatively connected to the infill resin in the container.
Compact ion source neutron generator (2023)

A neutron generator includes a conductive substrate comprising a plurality of conductive nanostructures with free-standing tips and a source of an atomic species to introduce the atomic species in proximity to the free-standing tips. A target placed apart from the substrate is voltage biased relative to the substrate to ionize and accelerate the ionized atomic species toward the target. The target includes an element capable of a nuclear fusion reaction with the ionized atomic species to produce a one or more neutrons as a reaction by-product.
Polar In-Plane Surface Orientation of a Ferroelectric Nematic Liquid Crystal: Field-Free Electrical Poling and Twisted State Electro-Optics (2020)

We demonstrate that the surface polarity of a ferroelectric nematic can be configured to generate vectorial control of the orientation of its bulk polarization field. The contact between a surface with in-plane polarity and a ferroelectric nematic liquid crystal generates preferred in-plane orientation of the ferroelectric polarization field at that interface, which can lead to the formation of fluid or glassy monodomains of high polarization without the need for electric field poling. Polyimide films, for example, unidirectionally buffed to provide both director pretilt and in-plane anisotropy, in addition provide macroscopic, in-plane polar order at the surface, as a route to making planar-aligned cells with a variety of azimuthal director/polarization structures, including twisted states. In a pi-twist cell, obtained with antiparallel, unidirectional buffing on opposing surfaces, we demonstrate three distinct modes of ferroelectric nematic electro-optic response: intrinsic, viscosity-limited field induced molecular reorientation; field-induced motion of domain walls separating twisted states of opposite chirality; and propagation of polarization reorientation solitons from the cell plates to the cell center upon field reversal.
Magnetic design for an IPT based wireless intraocular pressure regulating implant (2017)

Glaucoma is a serious ophthalmic disease threatening people all over the world. Intraocular pressure (IOP) measurement and regulation has been proved to be effective in detection and treatment of glaucoma. Currently, most of the IOP monitoring implants use RF technology and therefore cannot be easily integrated with automated drug delivery systems due to the limited power transfer capability. This paper introduces an IPT based continuous IOP monitoring device combined with an automated drug delivery system. An orthogonal polarized transmitter coil design and 4 mm circular receiver coil design that will facilitate efficient power and data transfer through magnetic induction are presented together with simulation results to validate the viability of the proposed IOP monitoring/regulating ocular implant. In comparison to conventional rectangular and DD type coil designs the proposed design significantly improves the magnetic coupling as well as the spatial freedom.
Corticosteroid Withdrawal after Complete Resection of Recurrent IgG4-Related Ophthalmic Disease (2020)

Corticosteroids are the first-line treatment for immunoglobulin G4-related ophthalmic disease (IgG4-ROD). However, the therapeutic effect of corticosteroids is unpredictable, and recurrences occur frequently. We present a case of a 60-year-old woman with IgG4-ROD of the lacrimal fossa. She was first treated with oral prednisolone, which was tapered within three months. However, proptosis recurred two months after prednisolone withdrawal. En bloc excision of the lesion was performed via the eyelid crease approach. The patient is lesion-free without corticosteroids at 18 months after surgery. Complete resection can be a powerful strategy for IgG4-ROD if a well-defined lesion is located in accessible areas.
Experimental Investigation of ERSFQ Circuit for Parallel Multibit Data Transmission (2017)

We present test results for parallel data communication ERSFQ circuits with clock recovery. We experimentally study on-chip and chip-to-chip parallel data communication circuits with 4-, 8- and 16-bit word lengths. The largest circuit is a 16-bit chip-to-chip communication test circuit embedded into a testbed with clock distributed over a combination of active and passive transmission lines with transmitter/receiver pairs, and is comprised of 3464 Josephson junctions in total. All ERSFQ circuits are fabricated using MITLL 10-kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SFQ5ee process. For the chip-to-chip communication experiment, a multi-chip module (MCM) is assembled using Hypres' MCM flip-chip bonding process which connected the MIT-LL-made flip-chip to the Hypres-made MCM carrier using 220 signal bumps with 50 um pitch. We experimentally confirmed correct functionality of 4-, 8- and 16-bit circuits and measured their current bias margins. For the 16- bit chip-to-chip communication circuit mounted to a MCM, we measured ±12% dc bias margins similar to the margins measured for the on-chip version of the same circuit. The MCM circuit is also evaluated at high clock speed generated by an external source, while the data words are changed at low speed. The correct functionality is observed without significant reduction in the bias margins using average-voltage test approach.
Synthesis, characterization, and thermodynamic analysis of a 1 + 1 self-assembling structure based on the cyanuric acid.cntdot.melamine lattice (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, and thermodynamic analysis of a 1 + 1 self-assembling structure based on the cyanuric acid.cntdot.melamine latticeChristopher T. Seto and George M. WhitesidesCite this: J. Am. Chem. Soc. 1993, 115, 4, 1330–1340Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ja00057a016https://doi.org/10.1021/ja00057a016research-articleACS PublicationsRequest reuse permissionsArticle Views684Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pomegranate juice: is it the new, all-natural phosphodiesterase type 5 inhibitor? (2008)

Pomegranate juice, which is derived from the pomegranate fruit, has been shown to have potent antioxidants, supposedly even more than in wine or green tea. It has recently been shown that it seems to protect nitric oxide (NO) in its continuing battle against oxidative stress, and it thereby has the potential to enhance the effect of NO on certain biologic systems.1 Because tumescence occurs as a result of an intact NO-cyclic guanosine monophosphate (cGMP) pathway within the cavernosal nerve and cavernosal smooth muscle cells, it seems logical to determine whether pomegranate juice can cause improvement in erectile function.
Thermal Conductivity of Polyimide/Carbon Nanofiller Blends (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.