gebhart/patrepeval huggingface dataset:
Tumor Necrosis Factor-Alpha Antagonists Twenty Years Later (2014)

In 1998, the U.S. Food and Drug Administration granted regulatory approval to the first tumor necrosis factor-α antagonist, infliximab, for the treatment of moderately to severely active Crohn's disease. As of 2013, there were 3 additional tumor necrosis factor-α antagonists commercially available for the treatment of inflammatory bowel disease in the United States: adalimumab, certolizumab pegol, and golimumab. Despite a vast literature describing both clinical trial and clinical practice experience with these agents, there remain important questions regarding the efficacy and safety of tumor necrosis factor-α antagonists for the treatment of inflammatory bowel disease. These questions and the best available evidence to answer them were discussed during a Cochrane Collaboration session held at the 2013 Digestive Diseases Week annual meeting. This article reviews the data from that session.
Large Scale Unmanned Vehicles Oceanic Exercise REP(MUS)19 Field Report (2021)

&lt;div&gt;The REP(MUS)19 is an exercise that takes place annually&lt;/div&gt;&lt;div&gt;since 2010 in the south of continental Portugal. LSTS (Underwater Systems and Technology Laboratory) has co-organized these events, since the beginning, together with the Portuguese Navy and, in more recent years, with NATO-CMRE. NATO’s MUS (Maritime Unmanned Systems Initiative) initiative joined the event in 2019. The target of these exercises is to have technological experimentation activities that engage armed forces, universities, and industry, in the unmanned system’s operation. The event operational environment enables interactions between all parties to share experiences and needs to drive research in the direction of real-life needs. LSTS’ participation in the 2019 event consisted of eight exercises.&lt;/div&gt;
Embarking on a 5 Year Journey to Highlight Genetic and Rare Diseases of the Central Nervous System (2017)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTEmbarking on a 5 Year Journey to Highlight Genetic and Rare Diseases of the Central Nervous SystemCraig W. LindsleyCite this: ACS Chem. Neurosci. 2017, 8, 11, 2349Publication Date (Web):November 15, 2017Publication History Published online15 November 2017Published inissue 15 November 2017https://pubs.acs.org/doi/10.1021/acschemneuro.7b00401https://doi.org/10.1021/acschemneuro.7b00401editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views613Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (171 KB) Get e-AlertscloseSUBJECTS:Central nervous system,Chemical neuroscience,Color,Genetics,Peptides and proteins Get e-Alerts
Many faces of Dengue encephalitis -Diversity of MRI Brain imaging findings (2020)

Poster: ECR 2020 / C-05937 / Many faces of Dengue encephalitis -Diversity of MRI Brain imaging findings by: S. KALE 1, D. P. kumar1, N. Panchal2, S. Agrawal3; 1Bengaluru+/IN, 2Mumbai/IN, 3Bangalore/IN
Complex of dipeptidyl peptidase II with adenosine deaminase (2008)

Dipeptidyl peptidase II (DPPII) from bovine kidney cortex and lung was purified to the electrophoretically homogeneous state. The molecular and catalytic characteristics of the enzyme were determined. It was revealed that DPPII preparations possess adenosine deaminase (ADA) activity at all purification steps. For the first time, the ADA-binding ability of DPPII has been shown similar to the well-known ADA-binding enzyme, DPPIV. The dissociation constant of the DPPII-ADA complex was estimated using a resonant mirror biosensor (80 nM), fluorescence polarization (60 nM), and differential spectroscopy (36 nM) techniques. The data demonstrate that DPPII can form a complex with ADA, but with one order of magnitude higher dissociation constant than that of DPPIV (7.8 nM).
Stress perception and response in a facultative halophyte: the regulation of salinity‐induced genes in Mesembryanthemum crystallinum (1993)

ABSTRACT The facultative halophyte Mesembryanthemum crystallinum (ice plant) shifts from C 3 to CAM photosynthesis in response to water stress. The switch to CAM can also be induced by high salinity, presumably because osmotic stress causes water loss from leaf and stem tissues. A number of mRNAs ( Ppc1, Imt1, B5 and Gpd1 ) that encode proteins involved in different biochemical pathways accumulate in M. crystallinum leaf tissues when plants are salt‐stressed. We hypothesized that environmental challenges that result in water stress invoke a common mechanism that triggers the coordinated induction of mRNAs involved in different aspects of the ice plant's adaptive stress response. Nuclear run‐on experiments indicated that Ppc1, Imt1, B5 and Gpd1 are all transcriptional I y activated in salt‐stressed leaf tissue. However, a comparison of Ppc1, Imt1 , and B5 transcript levels after exposure of plants to growth regulators (6‐benzylamino purine and abscisic acid) and to different environmental stress treatments that affect plant water status (drought, low temperature and salinity) indicated that, despite the coordinated transcriptional activation of these genes during salt stress, their repsonses to other stimuli that also upset water balance are not the same. Our results are consistent with a model involving multiple control mechanisms governing stress perception and molecular response in the ice plant.
Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses (2015)

Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into the kinetics of brain distribution of f-MWNTs in vivo has been reported. This study employed a wide range of qualitative and quantitative techniques with the aim of shedding the light on f-MWNT's brain distribution following intravenous injection. γ-Scintigraphy quantified the uptake of studied radiolabelled f-MWNT in the whole brain parenchyma and capillaries while 3D-single photon emission computed tomography/computed tomography imaging and autoradiography illustrated spatial distribution within various brain regions. Raman and multiphoton luminescence together with transmission electron microscopy confirmed the presence of intact f-MWNT in mouse brain, in a label-free manner. The results evidenced the presence of f-MWNT in mice brain parenchyma, in addition to brain endothelium. Such information on the rate and extent of regional and cellular brain distribution is needed before further implementation into neurological therapeutics can be made.
Formation of dodecaphenylporphodimethene via facile protonation of saddle-distorted dodecaphenylporphyrin (2008)

A saddle-distorted dodecaphenylporphyrin undergoes protonation followed by two-electron reduction by SnCl(2) to give a roof-shaped dodecaphenylporphodimethene which exhibits reversible one-electron reduction and oxidation behaviour in benzonitrile to allow us to observe an ESR spectrum of pi-cation radical in the course of electrochemical oxidation.
Molecular Pathogenesis of Lung Cancer (2002)

Lung cancer is the most common cause of cancer death in the United States, killing more than 156,000 people every year. In the past two decades, significant progress has been made in understanding the molecular and cellular pathogenesis of lung cancer. Abnormalities of proto-oncogenes, genetic and epigenetic changes of tumor suppressor genes, the role of angiogenesis in the multistage development of lung cancer, as well as detection of molecular abnormalities in preinvasive respiratory lesions, have recently come into focus. Efforts are ongoing to translate these findings into new clinical strategies for risk assessment, chemoprevention, early diagnosis, treatment selection, and prognosis and to provide new targets and methods of treatment for lung cancer patients. All these strategies should aid in reducing the number of newly diagnosed lung cancer cases and in increasing the survival and quality of life of patients with lung cancer.
Citations et références et dans les ouvrages historiques de Voltaire (2009)

info:eu-repo/semantics/published
ChemInform Abstract: Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773‐88K4. Part 1. Taxonomy, Fermentation, Isolation, Physico‐chemical Properties, and Biological Activities. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Co-design and optimization of a 256-GB/s 3D IC package with a controller and stacked DRAM (2012)

This paper presents a double-sided flip-chip package. The package consists of a memory controller on one side of an organic substrate, and 3D-stacked, disaggregated memory chips, integrated with TSVs, on the opposite side. Thermal isolation is one of the key motivations for this configuration. Co-design of all physical layers is required to optimize the integrated 3D package within electrical and manufacturing constraints. Double-sided flip-chip packaging also presents unique challenges in the design of the power delivery network (PDN). A pre-layout design strategy is described, which optimizes the PDN design across 11 power domains to meet stringent impedance targets.
Comparison of Test Methodologies for Foot-and-Mouth Disease Virus Serotype A Vaccine Matching (2014)

Vaccination has been one of the most important interventions in disease prevention and control. The impact of vaccination largely depends on the quality and suitability of the chosen vaccine. To determine the suitability of a vaccine strain, antigenic matching is usually studied by in vitro analysis. In this study, we performed three in vitro test methods to determine which one gives the lowest variability and the highest discriminatory capacity. Binary ethylenimine inactivated vaccines, prepared from 10 different foot-and-mouth disease (FMD) virus serotype A strains, were used to vaccinate cattle (5 animals for each strain). The antibody titers in blood serum samples 3 weeks postvaccination (w.p.v.) were determined by a virus neutralization test, neutralization index test, and liquid-phase blocking enzyme-linked immunosorbent assay (ELISA). The titers were then used to calculate relationship coefficient (r1) values. These r1 values were compared to the genetic lineage using receiver operating characteristic (ROC) analysis. In the two neutralization test methods, the median titers observed against the test strains differed considerably, and the sera of the vaccinated animals did not always show the highest titers against their respective homologous virus strains. When the titers were corrected for test strain effect (scaling), the variability (standard error of the mean per vaccinated group) increased because the results were on a different scale, but the discriminatory capacity improved. An ROC analysis of the r1 value calculated on both observed and scaled titers showed that only r1 values of the liquid-phase blocking ELISA gave a consistent statistically significant result. Under the conditions of the present study, the liquid-phase blocking ELISA showed less variation and still had a higher discriminatory capacity than the other tests.
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells (2019)

In AML, KIT<sup>N822K</sup> mislocalizes to EL. Our findings, however, suggest that the mutant transduces phosphorylation signals on lipid rafts of the Golgi in leukemia cells. Unexpectedly, the KIT<sup>V560G</sup> signal platform in MCL is similar to that of KIT<sup>N822K</sup> in AML. These observations provide new insights into the pathogenic role of KIT mutants as well as that of other mutant molecules.
The postantifungal effect of 5-fluorocytosine on Candida albicans (1992)

The in-vitro postantifungal effect (PAFE) of 5-fluorocytosine for Candida albicans for short periods of time was investigated. Yeast cells were exposed for 0.5, 1 or 2 h to a range of concentrations (0.1-3.2 mg/L) of 5-fluorocytosine. The PAFE was quantitated by determinations of the number of colony forming units at hourly intervals (0-10 h) after removal of the drug by dilution. The length of the PAFE was dependent upon the concentration of 5-fluorocytosine and the duration of exposure. An exposure time of 0.5 h resulted in PAFE's ranging from 0 to 4.2 h. Exposure times of 1 and 2 h resulted in longer PAFEs and in many instances suppression of cell growth was seen for the entire evaluation period (up to ten hours).
Advances in Livestock Nuclear Transfer (2000)

Abstract. Cloning and transgenic animal production have been greatly enhanced by the development of nuclear transfer technology. In the past, genetic modification in domestic animals was not tightly controlled. With the nuclear transfer technology one can now create some domestic animals with specific genetic modifications. An ever‐expanding variety of cell types have been successfully used as donors to create the clones. Both cell fusion and microinjection are successfully being used to create these animals. However, it is still not clear which stage(s) of the cell cycle for donor and recipient cells yield the greatest degree of development. While for the most part gene expression is reprogrammed in nuclear transfer embryos, all structural changes may not be corrected as evidenced by the length of the telomeres in sheep resulting from nuclear transfer. Even after these animals are created the question of “are they really clones?” arises due to mitochondrial inheritance from the donor cell versus the recipient oocyte. This review discusses these issues as they relate to livestock.
Arthroscopic Repair of Type II SLAP Lesions: Clinical and Magnetic Resonance Imaging Arthrogram Follow‐up (SS‐12) (2008)

Outcomes of arthroscopically repaired type II SLAP lesions were examined clinically and using MR-arthrography in this study. Twenty-five patients were reviewed and 20 agreed to have a postoperative MRI arthrogram to assess the integrity of the repair. Clinical outcomes following arthroscopic repair of type II SLAP lesions showed statistically significant improvement in shoulder scores (ASES, SST, patient satisfaction) from pre to post-operative. However, MRI arthrogram results did not necessarily correlate with clinical outcome.
Combining Full-Field Measurements and Inverse Techniques for Smart Material Testing (2017)

Traditionally, material properties (such as Young’s modulus, yield stress, etc.) are determined from a series of simple tensile and shear tests performed under various temperatures, strain rates, etc. This process is time-consuming and expensive. Additionally, material properties determined from simplified stress states may not adequately describe material behaviour under more complex loading conditions. In the past decade, full-field deformation measurements such as Digital Image Correlation (DIC) and inverse techniques such as the Virtual Fields Method (VFM) have reached a maturity level that takes them from the realm of development to the realm of application. This paper will present a concerted effort beginning at Sandia National Laboratory to explore a new experimental protocol for high-throughput, high-quality material identification by combining DIC, full-field temperature measurements, and VFM. Our current thrust is focused on identifying visco-plastic material parameters of 304L stainless steel. In particular, we will discuss the question of uniqueness of the material model and how parameter covariance affects material identification. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy’s National Nuclear Security Administration under contract No. DE-AC04-94AL85000.
22. LARGE OR MASSIVE ROTATOR CUFF TEARS BEFORE 65 YEARS: WHAT CAN BE DONE WHEN ANATOMIC REPAIR IS IMPOSSIBLE? (2011)

Purpose of the study: For patients aged less than 65 years who have a large rotator cuff tear, potential solutions include anatomic repair, palliative treatment, non-anatomic repair with flaps or cuff prosthesis, and reversed prosthesis. The later solution is not recommended at this age and anatomic repair is not always possible. In this situation, what is best, palliative treatment or flap or prosthesis repair? Material and method: This retrospective multicentric study included 142 patients, 74 men and 68 women with a large or massive cuff tear. Palliative treatment (group A) involved acromioplasty (n=48) associated as needed with a biceps procedure and partial repair (n=41). Non-anatomic repair (group B) included supra-spinatous translation (n=16), deltoid flaps (n=22), and cuff prostheses (n=15). Preoperatively, the two groups were not statistically different for acromiohumeral height (AH, 6 mm in group A versus 7.5 mm in group B) and percent of fatty infiltration of the infraspinatus > II (55% in group A versus 26% in group B). The Constant score, active and passive range of motion, gain in elevation and external rotation were noted. Results: Mean follow-up was 74 months in group A and 90 months in group B; the Constant score was 64 and 65, active elevation 145 and 147 and external rotation 17 and 26 respectively. The two groups were not significantly different. For patients with deficient elevation (n=46), the gain was 62 without any difference between the two groups. For patients with deficient external rotation (n=37), the gain was nil in both groups. Discussion: Although group A had a more severe condition than group B (narrower AH and more advanced fatty degeneration, the final outcome as assessed by the Constant score and range of motion was similar. Both groups recovered active elevation well, but not external rotation. Nevertheless, there were no cases of latissimus dorsi transfer in this series. Repair with a deltoid flap, supraspinatus translation, or cuff prosthesis does not appear to add any supplementary benefit despite the more aggressive surgery.
Variable span filters for speech enhancement (2016)

In this work, we consider enhancement of multichannel speech recordings. Linear filtering and subspace approaches have been considered previously for solving the problem. The current linear filtering methods, although many variants exist, have limited control of noise reduction and speech distortion. Subspace approaches, on the other hand, can potentially yield better control by filtering in the eigen-domain, but traditionally these approaches have not been optimized explicitly for traditional noise reduction and signal distortion measures. Herein, we combine these approaches by deriving optimal filters using a joint diagonalization as a basis. This gives excellent control over the performance, as we can optimize for noise reduction or signal distortion performance. Results from real data experiments show that the proposed variable span filters can achieve better performance than existing filters. In terms of output SNR, the gain was more than 8 dB, and more than 0.1 in mean opinion score in the conducted experiments.
A Wideband Lumped Circuit Model of the Terminal and Internal Electromagnetic Response of Rotating Machine Windings with a Coaxial Insulation System (2004)

The polyphase model can be used to simulate the terminal and internal electromagnetic response of, for example, Powerformer/spl trade/: a new power generator. The circuit parameters are based on geometrical and material data. The slot leakage is modeled by means of a reluctance circuit, which is coupled to the electric circuit by means of winding templates. The capacitive current and its losses in the outer semiconducting layer of the cable are modeled with a simplified version of an RC model that has been used previously for other coaxially insulated windings. The eddy current losses were neglected; however, it is presented how they can be included in the model. The simulated frequency and transient response of the lumped circuit is compared with measurements on an 11-MVA/45-kV, 600-r/min hydro Powerformer. With exception of the damping, the agreement is good, qualitatively, up to 100 kHz.
Synthesis and reactivity of sulphinyldithioacetate and sulphonyldithioacetate esters and some related compounds (1984)

(Methylsulphinyl)ketene dithioacetals (3) or alkyl (methylsulphinyl)dithioacetates (4), and (methyl-sulphonyl)ketene dithioacetals (16) or alkyl (methylsulphonyl)dithioacetates (17) were prepared from dimethyl sulphoxide and dimethyl sulphone, respectively. Then, bis-[2,2-bis(ethylthio)vinyl]sulphide, bis-[2,2-bis(ethylthio) vinyl] sulphoxide, and bis-[2,2-bis(methylthio)vinyl] sulphone were derived from (4) or (17). The reactivity of these compounds was examined.
Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum (2012)

Xeroderma pigmentosum (XP) is an orphan autosomal recessive disorder of DNA repair. When exposed to genotoxic stress, XP patients have reduced capacity to remove bulky adducts by nucleotide excision repair and are thus greatly predisposed to cancer. Unfortunately, given the nature of their underlying genetic defect, tumor-bearing XP patients cannot be treated with conventional DNA damaging therapies. Engineered strains of the poxvirus Vaccinia have been shown to cure cancer in numerous preclinical models, and based on promising Phase I/II clinical trials have recently been approved for late phase evaluation in humans. As poxviruses are nongenotoxic, we investigated whether clinical-candidate strains of Vaccinia can safely and effectively treat cancers arising from XP. In vitro, Vaccinia virus was highly cytotoxic against tumor-derived cells from XP patients, on average 10- to 100-fold more so than on nontumor derived control cells from similar patients. In vivo, local or systemic administration of Vaccinia virus led to durable tumor resolution in both xenograft and genetic models of XP. Importantly, Vaccinia virus was well tolerated in the genetic models, which are each null for a critical component of the DNA repair process. Taken together, our data suggest that oncolytic Vaccinia virus may be a safe and effective therapy for cancers arising from XP, and raise the possibility of similar therapeutic potential against tumors that arise in patients with other DNA repair disorders.