gebhart/patrepeval huggingface dataset:
NuSAP is essential for chromatin-induced spindle formation during early embryogenesis (2010)

Mitotic spindle assembly is mediated by two processes: a centrosomal and a chromosomal pathway. RanGTP regulates the latter process by releasing microtubule-associated proteins from inhibitory complexes. NuSAP, a microtubule- and DNA-binding protein, is a target of RanGTP and promotes the formation of microtubules near chromosomes. However, the contribution of NuSAP to cell proliferation in vivo is unknown. Here, we demonstrate that the expression of NuSAP highly correlates with cell proliferation during embryogenesis and adult life, making it a reliable marker of proliferating cells. Additionally, we show that NuSAP deficiency in mice leads to early embryonic lethality. Spindle assembly in NuSAP-deficient cells is highly inefficient and chromosomes remain dispersed in the mitotic cytoplasm. As a result of sustained spindle checkpoint activity, the cells are unable to progress through mitosis, eventually leading to caspase activation and apoptotic cell death. Together, our findings demonstrate that NuSAP is essential for proliferation of embryonic cells and, simultaneously, they underscore the importance of chromatin-induced spindle assembly.
Photosensitisation of inkjet printed graphene with stable all-inorganic perovskite nanocrystals (2022)

All-inorganic perovskite nanocrystals (NCs) with enhanced environmental stability are of particular interest for optoelectronic applications. Here we report on the formulation of CsPbX<sub>3</sub> (X is Br or I) inks for inkjet deposition and utilise these NCs as photosensitive layers in graphene photodetectors, including those based on single layer graphene (SLG) as well as inkjet-printed graphene (iGr) devices. The performance of these photodetectors strongly depends on the device structure, geometry and the fabrication process. We achieve a high photoresponsivity, <i>R</i> > 10<sup>6</sup> A W<sup>-1</sup> in the visible wavelength range and a spectral response controlled by the halide content of the perovskite NC ink. By utilising perovskite NCs, iGr and gold nanoparticle inks, we demonstrate a fully inkjet-printed photodetector with <i>R</i> ≈ 20 A W<sup>-1</sup>, which is the highest value reported to date for this type of device. The performance of the perovskite/graphene photodetectors is explained by transfer of photo-generated charge carriers from the perovskite NCs into graphene and charge transport through the iGr network. The perovskite ink developed here enabled realisation of stable and sensitive graphene-based photon detectors. Compatibility of inkjet deposition with conventional Si-technologies and with flexible substrates combined with high degree of design freedom provided by inkjet deposition offers opportunities for partially and fully printed optoelectronic devices for applications ranging from electronics to environmental sciences.
ChemInform Abstract: APPARENT FLUXIONALITY IN DIETHYL(TRIETHYLPHOSPHINE)PLATINUM(II), A COORDINATIVELY UNSATURATED INTERMEDIATE IN β‐HYDRIDE ELIMINATION (1981)

Abstract Der Mechanismus der thermischen Zersetzung des Pt‐Komplexes (I) in Cyclohexanlösung wird anhand kinetischer und Isotopenmarkierungs‐Untersuchungen diskutiert.
Iron, cobalt, and nickel complexes having anomalous magnetic moments (1968)

E. K. Barefield, D. H. Busch and S. M. Nelson, Q. Rev. Chem. Soc., 1968, 22, 457 DOI: 10.1039/QR9682200457
Blood Flow Characterization in a Perfused Collagen Vessel Bioreactor Using X-Ray Micro-PIV (2012)

Newly developed cancer therapies must pass through a series of increasingly complex testing regimens before obtaining FDA approval as valid treatments. The costs of these tests increase rapidly as the physiological accuracy of the platform increases, from initial proof-of-concept in static tissue cultures, to treatment of animal models, and ultimately to human clinical trials. Three-dimensional engineered blood-perfused tumor models are becoming increasingly important as intermediate platforms for the study and treatment of cancer, as they are superior to static two-dimensional cultures in their reproduction of relevant physiological conditions and are inexpensive in comparison to animal models. Because of this, the design of well-characterized adaptable in vitro vascular tumor models has become a central objective of the emerging field of tumor engineering. Characterization of the flow within three-dimensional tumor models is critical for quantifying fluid shear stress and determining its role in pivotal tumor development processes such as tumor cell angiogenesis and metastasis. Ultimately, this knowledge will provide new avenues for therapeutic modulation of the tumor microenvironment.
Meeting report for the 1st skin microbiota workshop, boulder, CO October 15-16 2012 (2014)

This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The workshop was arranged to bring Department of Defense personnel together with experts in microbial ecology, human skin physiology and anatomy, and computational techniques for interrogating the microbiome to define research frontiers at the intersection of these important areas. The workshop outlined a series of questions and created several working groups to address those questions, specifically to promote interdisciplinary activity and potential future collaboration. The US Army provided generous grant support and the meeting was organized and hosted by the University of Colorado at Boulder. A primary forward vision of the meeting was the importance of understanding skin microbial communities to improve the health and stealth of US Army warfighters.
Ultraschallbasiertes Knochenschneiden in der Oralchirurgie: eine Übersicht anhand von 60 Patientenfällen (2008)

Piezosurgery is an advantageous osteotomy technique for delicate structures in the oral and maxillofacial region. With respect to osteotomies of thin and fragile bones, the application of ultrasound is superior to other mechanical instruments because of the extremely precise and virtually arbitrary cut geometries, easy handling, efficient bone ablation and minimal accidental damage to adjacent soft tissue structures.
Extrasynaptic volume transmission: A novel route for neuropeptide signaling in nematodes (2020)

Abstract Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for our understanding of nematode nervous system function. However, other non-synaptic routes of communication are known in invertebrates including extrasynaptic volume transmission (EVT), which enables short- and/or long-range communication in the absence of synaptic connections. Although EVT has been highlighted as a facet of Caenorhabditis elegans neurosignaling, no experimental evidence identifies body cavity fluid (pseudocoelomic fluid; PCF) as a vehicle for either neuropeptide or biogenic amine transmission. In the parasitic nematode Ascaris suum FMRFamide-like peptides encoded on flp -18 potently stimulate female reproductive organs but are only expressed in cells that are anatomically distant from the reproductive organ, with no known synaptic connections to this tissue. Here we report a new non-synaptic mode of signaling in nematodes mediated by neuropeptides within the PCF. Our data show that: (i) A. suum PCF (As-PCF) contains a catalogue of neuropeptides including FMRFamide-like peptides and neuropeptide-like proteins; (ii) the A. suum FMRFamide-like peptide As-FLP-18A dominates the As-PCF peptidome; (iii) As-PCF potently modulates nematode reproductive muscle function ex vivo , mirroring the effects of synthetic FLP-18 peptides; (iv) As-PCF activates the C. elegans FLP-18 receptors NPR-4 and -5; (v) As-PCF alters C. elegans behavior and, (vi) FLP-18 and FLP-18 receptors display pan-phylum distribution in nematodes. Here we provide the first direct experimental evidence that supports an extrasynaptic volume route for neuropeptide transmission in nematodes. These data demonstrate non-synaptic signaling within the nematode functional connectome and are pertinent to receptor deorphanisation approaches underpinning drug discovery programs for nematode pathogens.
To fix or to learn? How production bias affects developers' information foraging during debugging (2015)

Developers performing maintenance activities must balance their efforts to learn the code vs. their efforts to actually change it. This balancing act is consistent with the “production bias” that, according to Carroll's minimalist learning theory, generally affects software users during everyday tasks. This suggests that developers' focus on efficiency should have marked effects on how they forage for the information they think they need to fix bugs. To investigate how developers balance fixing versus learning during debugging, we conducted the first empirical investigation of the interplay between production bias and information foraging. Our theory-based study involved 11 participants: half tasked with fixing a bug, and half tasked with learning enough to help someone else fix it. Despite the subtlety of difference between their tasks, participants foraged remarkably differently-making foraging decisions from different types of “patches,” with different types of information, and succeeding with different foraging tactics.
MECP2 mutation analysis in patients with mental retardation (2004)

Abstract Mutations in the methyl‐CpG‐binding protein 2 ( MECP2 ) gene are known to underlie Rett' syndrome, the most common cause of mental retardation (MR) in girls. Since the original report, phenotypes resulting from MECP2 mutations have been shown to extend, for example, to several Rett variants, autism, atypical Angelman syndrome, and nonspecific MR. It was earlier proposed that MECP2 mutations might account for ∼2% of the male cases with nonspecific MR. Thereby, the frequency of MECP2 mutations in the mentally retarded population would be comparable to that of Fragile‐X syndrome. The aim of this study was to analyze well‐characterized cases with MR and to clarify the role of the MECP2 gene in the etiology of MR and atypical Angelman syndrome. The coding sequence of the MECP2 gene was analyzed in a sample of 118 patients (103 males, 15 females) by direct sequencing. Two coding sequence variants, 602C &gt; T (A201V) and 1189G &gt; A (E397K), were identified. In addition, we identified four variants in the intronic or 3′UTR regions. None of these variants is likely to be causal. We conclude that the evidence across all the mutation screening studies implies that MECP2 mutations do not represent a major cause of nonspecific MR. © 2004 Wiley‐Liss, Inc.
Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success (2016)

Acute kidney injury (AKI) remains a vexing clinical problem that results in unacceptably high patient mortality, development of chronic kidney disease, and accelerated progression to end-stage kidney disease. Although clinical risks factors for developing AKI have been identified, there is no reasonable surveillance technique to definitively and rapidly diagnose and determine the extent of severity of AKI in any patient. Because patient outcomes correlate with the extent of injury, and effective therapy likely requires early intervention, the ability to rapidly diagnose and stratify patients by their level of kidney injury is paramount for translational progress. Many groups are developing and characterizing optical measurement techniques using novel minimally invasive or noninvasive techniques that can quantify kidney function independent of serum or urinary measurements. The use of both one- and two-compartment models, as well as continuous monitoring, are being developed. This review documents the need for glomerular filtration rate measurement in AKI patients and discusses the approaches being taken to deliver this overdue technique that is necessary to help propel nephrology to individualization of care and therapeutic success.
Moisture in cellulose insulation of power transformers - statistics (2013)

The article presents the results of extensive investigations aimed at determining the moisture content in a large population of power transformers (161 units). The project was carried out during the period of 2003-2011 in Poland, Germany, and Sweden. All results were obtained by means of the Frequency Response Spectroscopy (FDS) method. Among the transformers tested were grid transformers, generator step-up (GSU) transformers, and distribution transformers. According to the classification rules established by IEEE, 30% among the investigated transformers could be classified as “wet” (2-4% moisture content). The observed moisture variation with age was found to depend on transformer design and operating conditions. It is suggested that, based on the presented statistical results and knowledge concerning transformer type and age, one may discriminate between probably dry transformers and transformers that require actual moisture analysis and therefore prioritize further condition assessment.
An efficient method for calculating finite‐difference seismograms after model alterations (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999An efficient method for calculating finite‐difference seismograms after model alterationsAuthors: Johan O. A. RobertssonChris H. ChapmanJohan O. A. RobertssonSchlumberger and Chris H. ChapmanSchlumbergerhttps://doi.org/10.1190/1.1820903 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820903FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Johan O. A. Robertsson and Chris H. Chapman, (1999), "An efficient method for calculating finite‐difference seismograms after model alterations," SEG Technical Program Expanded Abstracts : 1848-1851. https://doi.org/10.1190/1.1820903 Plain-Language Summary PDF DownloadLoading ...
Role of Ca 2+ -Activated K + Channels in the Regulation of Membrane Potential and Tone of Smooth Muscle in Human Pial Arteries (1996)

Smooth muscle cells (SMCs) in 58% of human pial arteries obtained during surgery showed no spontaneous contractions and displayed a stable resting membrane potential (MP) of -54.7 +/- 1.5 mV. Those that exhibited periodic spontaneous contractions associated with periodic depolarization and generation of spontaneous action potentials (APs) had a less negative MP of -43.1 +/- 0.5 mV (42%). Inhibition of calcium-activated potassium (KCa) channels in the silent arteries by charybdotoxin (CTX) and tetraethylammonium ions (TEA) induced dose-dependent depolarization, AP generation, and contraction. TEA and CTX enhanced the spontaneous depolarization and force in arteries that exhibited spontaneous activity. They also prolonged the spontaneous APs up to several times and increased their upstroke amplitude. Both TEA and CTX failed to produce significant depolarization in arteries treated with nifedipine. It is concluded that KCa channels are important regulators of human pial artery SMC resting MP and tone. They are also involved in the control of AP amplitude and duration and the associated contractions. These data suggest that alterations in the activity of SMC KCa channels could be responsible for the appearance of spontaneous activity in human pial arteries in vitro and that impaired function of these channels might be related to vasospastic phenomena in human cerebral circulation.
AR-HITOKE (2015)

We propose a shopping support system (AR-HITOKE) that visualizes the popularity of brick and mortar shops by aggregating online and offline information using augmented reality technology that can be understood intuitively. In the proposed method, 3D-animated human-shaped icons in queues and user comments are overlaid above a shop's location on a physical map. Popularity is expressed visually by adjusting the queues length depending on offline sales data. We also visualize user comments related to each shop that are extracted from online reviews using our sentiment analysis framework. The proposed method offers new evaluation information for decision making in a physical environment and new online shopping experiences. Through exhibition of the proposed system at an actual event, we found that users are able to recognize the popularity of shops intuitively.
Placement of an esophageal self-expandable metal stent through a percutaneous endoscopic gastrostomy tract, for endoscopic therapy of upper gastrointestinal bleeding (2012)

Slim endoscopes can be passed through gastrostomy tracts, but dilation is required for the passage of standard endoscopes, which may result in tract disruption. Large-diameter covered self-expandable metal stents (CSEMS) have been placed through percutaneous tracts to enable endotherapy.
COCOI: Contact-aware Online Context Inference for Generalizable Non-planar Pushing (2021)

General contact-rich manipulation problems are long-standing challenges in robotics due to the difficulty of understanding complicated contact physics. Deep reinforcement learning (RL) has shown great potential in solving robot manipulation tasks. However, existing RL policies have limited adaptability to environments with diverse dynamics properties, which is pivotal in solving many contact-rich manipulation tasks. In this work, we propose Contact-aware Online COntext Inference (COCOI), a deep RL method that encodes a context embedding of dynamics properties online using contact-rich interactions. We sample sensor data using a novel contact-aware strategy and formulate an interpretable dynamics transition module. We study this method based on a novel and challenging non-planar pushing task, where the robot uses a monocular camera image and wrist force torque sensor reading to push an object to a goal location while keeping it upright. We run extensive experiments to demonstrate the capability of COCOI in a wide range of settings and dynamics properties in simulation, and also in a sim-to-real transfer scenario on a real robot (Webpage: https://context-inference.github.io/).
Why Compete When You Can Work Together: FPGA-ASIC Integration for Persistent RNNs (2019)

Interactive intelligent services, such as smart web search, are important datacenter workloads. They rely on dataintensive deep learning (DL) algorithms with strict latency constraints and thus require balancing both data movement and compute capabilities. As such, a persistent approach that keeps the entire DL model on-chip is becoming the new norm for realtime services to avoid the expensive off-chip memory accesses. This approach is adopted in Microsoft's Brainwave and is also provided by Nvidia's cuDNN libraries. This paper presents a comparative study of FPGA, GPU, and FPGA+ASIC in-package solutions for persistent DL. Unlike prior work, we offer a fair and direct comparison targeting common numerical precisions (FP32, INT8) and modern high-end FPGA (Intel® Stratix®10), GPU (Nvidia Volta), and ASIC (10 nm process), all using the persistent approach. We show that Stratix 10 FPGAs offer 2.7× (FP32) to 8.6× (INT8) lower latency than Volta GPUs across RNN, GRU, and LSTM workloads from DeepBench. The GPU can only utilize ~6% of its peak TOPS, while the FPGA with a more balanced on-chip memory and compute can achieve much higher utilization (~57%). We also study integrating an ASIC chiplet, TensorRAM, with an FPGA as system-in-package to enhance on-chip memory capacity and bandwidth, and provide compute throughput matching the required bandwidth. We show that a small 32 mm2 TensorRAM 10nm chiplet can offer 64 MB memory, 32 TB/s on-chiplet bandwidth, and 64 TOPS (INT8). A small Stratix 10 FPGA with a TensorRAM (INT8) offers 15.9× better latency than GPU (FP32) and 34× higher energy efficiency. It has 2× aggregate on-chip memory capacity compared to a large FPGA or GPU. Overall, our study shows that the FPGA is better than the GPU for persistent DL, and when integrated with an ASIC chiplet, it can offer a more compelling solution.
Un Mécanisme de Commutation pour Réduire les Problèmes de Direction Aveugle dans les Réseaux à Balayage (2017)

International audience
Topical Rosiglitazone Is an Effective Anti-Scarring Agent in the Cornea (2013)

Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome proliferator activated receptor gamma (PPARγ), can effectively block scar formation in a cat model of corneal damage. Adult cats underwent bilateral epithelial debridement followed by excimer laser ablation of the central corneal stroma to a depth of ~160 µm as a means of experimentally inducing a reproducible wound. Eyes were then left untreated, or received 50 µl of either 10 µM Rosiglitazone in DMSO/Celluvisc, DMSO/Celluvisc vehicle or Celluvisc vehicle twice daily for 2 weeks. Cellular aspects of corneal wound healing were evaluated with in vivo confocal imaging and post-mortem immunohistochemistry for alpha smooth muscle actin (αSMA). Impacts of the wound and treatments on optical quality were assessed using wavefront sensing and optical coherence tomography at 2, 4, 8 and 12 weeks post-operatively. In parallel, cat corneal fibroblasts were cultured to assess the effects of Rosiglitazone on TGFβ-induced αSMA expression. Topical application of Rosiglitazone to cat eyes after injury decreased αSMA expression and haze, as well as the induction of lower-order and residual, higher-order wavefront aberrations compared to vehicle-treated eyes. Rosiglitazone also inhibited TGFβ-induced αSMA expression in cultured corneal fibroblasts. In conclusion, Rosiglitazone effectively controlled corneal fibrosis in vivo and in vitro, while restoring corneal thickness and optics. Its topical application may represent an effective, new avenue for the prevention of corneal scarring with distinct advantages for pathologically thin corneas.
Proceedings of the 5th Annual Symposium and Bootcamp on Hot Topics in the Science of Security (2018)

The goal of HotSoS is to bring together researchers, practitioners, and thought leaders from government, industry, and academia, and to provide a forum for dialog centered upon the development and advancement of scientific foundations in cybersecurity. The technical emphasis of HotSoS lies on building a foundational science of security, incorporating scientific methods, data gathering and analysis, experimental approaches, mathematical models, and the interactions among them. The HotSoS vision is one of engaging and growing a community including researchers and skilled practitioners from diverse disciplines that is focused around the advancement of scientific methods as applied to cybersecurity.
Functionality-rich versus minimalist platforms (2011)

Should a new "platform" target a functionality-rich but complex and expensive design or instead opt for a bare-bone but cheaper one? This is a fundamental question with profound implications for the eventual success of any platform. A general answer is, however, elusive as it involves a complex trade-off between benefits and costs. The intent of this paper is to introduce an approach based on standard tools from the field of economics, which can offer some insight into this difficult question. We demonstrate its applicability by developing and solving a generic model that incorporates key interactions between platform stakeholders. The solution confirms that the "optimal" number of features a platform should offer strongly depends on variations in cost factors. More interestingly, it reveals a high sensitivity to small relative changes in those costs. The paper's contribution and motivation are in establishing the potential of such a cross-disciplinary approach for providing qualitative and quantitative insights into the complex question of platform design.