gebhart/patrepeval huggingface dataset:
Value of the resting 12 lead electrocardiogram and vectorcardiogram for locating the accessory pathway in patients with the Wolff-Parkinson-White syndrome. (1987)

The resting 12 lead electrocardiogram and vectocardiogram were reviewed in 47 patients with the Wolff-Parkinson-White syndrome (a) who had pre-excitation on the resting 12 lead electrocardiogram, (b) who had a single anterograde conducting accessory pathway assessed and located during preoperative electrophysiological study and during epicardial mapping at operation, and (c) in whom surgical division of the accessory pathway resulted in loss of pre-excitation. The site of the accessory pathway established during operation was compared with that established by evaluating the polarity of the delta wave and QRS complex on the resting 12 lead electrocardiogram. The electrocardiogram was assessed by the Rosenbaum criteria (Wolff-Parkinson-White type A, left-sided pathway; or type B, right-sided pathway), the Gallagher criteria (atrial pacing resulting in maximal pre-excitation), and the World Health Organisation criteria (a composite of previous studies). The Gallagher and World Health Organisation criteria were derived from patients demonstrating maximal pre-excitation that often required atrial pacing. The present study was designed to determine whether these criteria could be accurately applied to the resting 12 lead electrocardiogram on which the degree of pre-excitation was variable. The Rosenbaum criteria correctly identified a left sided accessory pathway in 26 of 34 patients and a right-sided accessory pathway in nine of 13 patients. The Gallagher and World Health Organisation criteria correctly identified the location in only 15 (32%) of the 47 patients. The resting vectorcardiogram was inaccurate for locating the accessory pathway. Although published criteria are useful for identifying the site of the accessory pathway from an electrocardiogram obtained when rapid atrial pacing is being used to achieve maximal pre-excitation, they are not suitable for identifying the exact site of an accessory pathway from the resting 12 lead electrocardiogram.
Process Quality Control: Troubleshooting and Interpretation of Data (1991)

Part I: Basics of Interpretation of Data.Variables Data: An Introduction.Ideas from Time Sequences of Observations.Ideas from Outliers-Variables Data.Variability--Estimating and Comparing.Attributes or Go No-Go Data.Part II: Statistical Process Control.On Sampling to Provide Feedback of Information.Narrow Limit Gauging in Process Control.On Implementing Statistical Process Control.Part III: Troubleshooting and Process Improvement.Some Basic Ideas and Methods of Troubleshooting.Some Concepts of Statistical Design of Experiments.Troubleshooting with Attributes Data.Special Strategies in Troubleshooting.Comparing Two Process Averages.Troubleshooting with Variables Data.More Than Two Levels of an Independent Variable.
ChemInform Abstract: Synthesis, Ligand Binding, and Quantitative Structure‐Activity Relationship Study of 3β‐(4′‐Substituted phenyl)‐2β‐ heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β‐Position. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
True time delay w/3D MEMs (2005)

A fiber delay integrated switch (FIDELIS) photonic beamformer using a large optical switch allows compact implementation of true time delay for phased array radars. The use of a three-level subarray architecture enables very large beamformer arrays using only a small number of photonic time delays.
Chirurgische Therapie der primär sklerosierenden Cholangitis (2020)

The majority of patients with PSC have to be operated on because of the disease with substantial risks for morbidity and mortality. Curative treatment options are lacking, thus underlining the need for effective early detection and treatment strategies for PSC-CCC.
Supplementary Figure S2 from RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across <i>FGFR2</i> Alterations and Resistance Mutations (2023)

&lt;p&gt;Supplementary Figure 2. Treatment with RLY-4008 is well-tolerated and leads to dose-dependent inhibition of FGFR2 and tumor regression in multiple FGFR2-altered tumor models.&lt;/p&gt;
Polyphonic Music Modelling with LSTM-RTRBM (2015)

Recent interest in music information retrieval and related technologies is exploding. However, very few of the existing techniques take advantage of the recent advancements in neural networks. The challenges of developing effective browsing, searching and organization techniques for the growing bodies of music collections call for more powerful statistical models. In this paper, we present LSTM-RTRBM, a new neural network model for the problem of creating accurate yet flexible models of polyphonic music. Our model integrates the ability of Long Short-Term Memory (LSTM) in memorizing and retrieving useful history information, together with the advantage of Restricted Boltzmann Machine (RBM) in high dimensional data modelling. Our approach greatly improves the performance of polyphonic music sequence modelling, achieving the state-of-the-art results on multiple datasets.
Performance of planar ortho-mode transducers for CMB satellite missions (2010)

Planar waveguide E-field probes have been used in a number of millimeter wave instruments although usually for single polarization detection in rectangular waveguide. The coupling efficiency of these types of probes is found to be high over the full waveguide bandwidth. Because of the advantages in integration, scalability and mass of planar OMTs compared to external waveguide OMTs, a planar OMT coupled to a corrugated horn is a good option for future CMB polarisation missions such as B-Pol. We estimate the performance of planar OMTs where the signals from the probes are combined after detection (power combination) and before detection (field combination) and show that under ideal circumstances the two methods give equivalent performance over a 20% bandwidth. However, field combination suppresses coupling to higher order waveguide modes and therefore enables wider bandwidth operation (up to 40%). We present a design of an ortho-mode transducer (OMT) to separate two orthogonal linearly polarized signals traveling in a circular waveguide in the frequency band from 190-250 GHz band using 4 probes in circular waveguide. In this design, the power in each linear polarisation is divided between two opposite probes. A field combiner (hybrid coupler) combines the signals from the probes on opposite sides of the waveguide before detection using planar microstrip structures. We use Ansoft/HFSS 3-D electromagnetic simulation software and the Agilent Advanced Design System (ADS) to evaluate the performance of the design and to determine the optimal probe geometry and feed impedance. The main questions have been investigated for this technology are coupling efficiency and cross-polarization response, achievable bandwidth, and scalability. Performance of Planar Ortho-Mode Transducers for CMB satellite missions Jin Zhang1, Philip Mauskopf1, Stafford Withington2, David Goldie2, Dorota Glowacka2
Micellization and adsorption of surfactant in a nonpolar liquid in micrometer scale geometries (2010)

Mixtures of nonpolar liquid and surfactant are used increasingly in applications with microscopic dimensions. However, most methods to characterize them are performed on bulk solutions. We measure electrical transient currents in thin layers of nonpolar liquid with surfactant and derive several properties from these measurements. This paper reports the results for different liquid layer thicknesses and surfactant concentrations. We observe a dependence on the layer thickness of the inverse micelle concentration, which cannot be explained by bulk micellization alone. A model including surface adsorption is proposed that describes surfactant behavior in microscale geometries.
Anonymous Attestation Using the Strong Diffie Hellman Assumption Revisited. (2016)

Direct Anonymous Attestation (DAA) is a cryptographic protocol for privacy-protecting authentication. It is standardized in the TPM standard and implemented in millions of chips. A variant of DAA is also used in Intel’s SGX. Recently, Camenisch et al. (PKC 2016) demonstrated that existing security models for DAA do not correctly capture all security requirements, and showed a number of flaws in existing schemes based on the LRSW assumption. In this work, we identify flaws in security proofs of a number of qSDH-based DAA schemes and point out that none of the proposed schemes can be proven secure in the recent model by Camenisch et al. (PKC 2016). We therefore present a new, provably secure DAA scheme that is based on the qSDH assumption. The new scheme is as efficient as the most efficient existing DAA scheme, with support for DAA extensions to signature-based revocation and attributes. We rigorously prove the scheme secure in the model of Camenisch et al., which we modify to support the extensions. As a side-result of independent interest, we prove that the BBS+ signature scheme is secure in the type-3 pairing setting, allowing for our scheme to be used with the most efficient pairing-friendly curves.
Motion vector analysis based homography estimation for efficient HEVC compression of 2D and 3D navigation video sequences (2013)

Navigation systems have become complex devices in automobiles nowadays. As part of large in-car infotainment systems, these devices undergo extensive hardware and software tests in order to assert correct system behavior under all circumstances. During field tests, the display output is typically recorded in compressed form for days or weeks, followed by a thorough analysis of the video data. In this paper, we demonstrate how to setup an HEVC-based compression solution specifically designed for navigation sequence content. We show how rotational motion, which is a dominant characteristic, can be estimated and compensated in an efficient way. We avoid any complex feature-based approaches for global motion estimation but find precise motion parameters by analyzing and filtering motion vector sets produced by HEVC during encoding. While achieving compression efficiency similar to a feature-based approach, processing time for global motion estimation can be significantly reduced.
Supplementary Methods and Figure Legend from Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling (2023)

&lt;p&gt;PDF file - 112K&lt;/p&gt;
Protecting privacy while sharing medical data between regional healthcare entities. (2007)

Economies of scale, corporate partnerships and a need to increase the efficiency of Information Technology in the Healthcare sector are leading to the construction of Regional Health Information Organizations (RHIOs) across the United States. RHIOs are normally aligned by service provision given by particular healthcare payers (e.g. Blue Cross-Blue Shield, PacifiCare etc.) in particular geographies. Globalization has created a transient workforce that may require their healthcare provider access their patient data across several sovereign RHIOs. The barrier to enabling RHIO to RHIO collaboration lies in the need to respect the data disclosure policy of each RHIO, to adhere to the geography-specific healthcare legislation and also to not violate the express privacy wishes of the patient(s) involved. In this paper, we propose a data-level control called Sticky Policy Enforcement which allows sharing to occur across RHIOs, while adhering to the concerns mentioned.
SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. (1993)

P210 BCR/ABL is a chimeric oncogene implicated in the pathogenesis of chronic myelogenous leukemia. BCR sequences have been shown to be required for activation of the tyrosine kinase and transforming functions of BCR/ABL. In this work, we show that two other structural requirements for full transforming activity of P210 BCR/ABL include a functional tyrosine kinase and the presence of tyrosine 1294, a site of autophosphorylation within the tyrosine kinase domain. Replacement of tyrosine 1294 with phenylalanine (1294F) greatly diminishes the transforming activity of BCR/ABL without affecting the specific activity of the protein tyrosine kinase. Expression of an exogenous myc gene in fibroblasts partially complements the transforming capacity of mutant P210 BCR/ABL (1294F). Surprisingly, tyrosine 1294 is not required for efficient induction of growth factor-independence in hematopoietic cell lines by P210 BCR/ABL. These results suggest that autophosphorylation at tyrosine 1294 may be important for recognition and phosphorylation of cellular substrates in the pathway of transformation, but it is not critical for mediating the events which lead to growth factor independence.
Modulation of P-Glycoprotein (PGP) Mediated Multidrug Resistance (MDR) Using Chemosensitizers: Recent Advances in the Design of Selective MDR Modulators (2001)

Over the past two decades, a number of chemical entities have been investigated in the continuing quest to reverse P-glycoprotein (PGP) mediated multidrug resistance (MDR) in cancer. The complexity of interactions between these agents and the proteins responsible for MDR in conjunction with the challenges associated with developing SAR/QSAR relationships for MDR modulators has hampered our ability to develop agents that modulate MDR with enhanced specificity of target, increased efficacy, and minimized toxicity when coadministered with anticancer drugs. With an increased understanding of the molecular interaction, target-mediated SAR and combinatorial chemistry approaches, newer more selective inhibitors have been recently reported. These agents have shown remarkable promise in preclinical trials; although their ultimate clinical therapeutic utility remains to be established. The emphasis of this review is placed on the current understanding of modulator-drug transport protein interactions and to review the advances in the structure-based design, synthetic efforts and the cellular pharmacology of MDR modulating activity of a number of known PGP inhibitors.
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement (2005)

FTY720 is an immunosuppressive agent that modulates lymphocyte trafficking. It is phosphorylated in vivo to FTY720-phosphate (FTY-P) and binds to a family of G protein-coupled receptors recognizing sphingosine 1-phosphate (S1P) as the natural ligand. It has previously been reported that FTY-P blocks egress of lymphocytes from the thymus and lymph nodes, resulting in peripheral blood lymphopenia. We now report that FTY-P also causes displacement of marginal zone (MZ) B cells to the splenic follicles, an effect that is similar to that observed after in vivo administration of lipopolysaccharide. This effect is specific to B cells in the MZ, as treatment with FTY-P does not cause redistribution of the resident macrophage population. A small but statistically significant decrease in the expression of beta1 integrin on MZ B cells was observed with FTY-P treatment. The redistribution of MZ B cells from the MZ sinuses does not abolish the ability of these cells to respond to the T-independent antigen, trinitrophenol-Ficoll. It has been proposed that the displacement of MZ B cells to the follicles is an indication of cell activation. Consistent with this, FTY-P caused an increase in percentage of MZ B cells expressing activation markers CD9, CD1d, and CD24. These results suggest that S1P receptors on MZ B cells are responsible for their mobilization to follicles.
High Sensitivity Collisionally-activated Decomposition Tandem Mass Spectrometry on a Novel Quadrupole/Orthogonal-acceleration Time-of-flight Mass Spectrometer (1996)

Consideration of the special problems encountered in ultra-high sensitivity biopolymer sequencing studies has led to the development of a novel quadrupole/erthogonal-acceleration time-of-flight tandem mass spectrometer described for the first time here. The performance characteristics of this new geometry are demonstrated, including fully resolved daughter-ion spectra with mass accuracies of 0.1 dalton, which allow removal of interpretation ambiguities and easy differentiation of charge states even in weak collisionally-activated decomposition tandem mass spectra. The instrument has been applied to a variety of biopolymer research problems, including the structure determination of major histocompatibility complex peptide antigens using liquid chromatography/electrospray mass spectrometry and nanoflow-electrospray tandem mass spectrometry, and sequencing capability in the low-femtomole and attomole ranges is demonstrated.
Bile acids with cyclopropane-containing side chain. 2. Synthesis and properties of 3.alpha.,7.beta.-dihydroxy-22,23-methylene-5.beta.-cholan-24-oic acid (2-sulfoethyl)amide (1985)

The preparation of 3 alpha,7 beta-dihydroxy-22,23-methylene-5 beta-cholan-24-oic acid (2-sulfoethyl)amide (5) by the one-step EEDQ-induced conjugation between ursodeoxycholic acid "cyclopropylog" (4) and taurine is described. The presence of a cyclopropyl ring adjacent to the amide bond is shown to make it resistant to degradation by intestinal bacteria. This new cyclopropylog is neither deconjugated at the C-24 amide bond nor 7-dehydroxylated when incubated with human stools in anaerobic conditions.
A Naturally Occurring Single-Residue Mutation in the Translocator Domain of Neisseria meningitidis NhhA Affects Trimerization, Surface Localization, and Adhesive Capabilities (2011)

Neisseria meningitidis NhhA (Neisseria hia/hsf homologue A) is an oligomeric outer membrane protein belonging to the family of trimeric autotransporter adhesins. NhhA mediates the interaction of N. meningitidis with human epithelial cells and components of the extracellular matrix. The recombinant protein is able to induce bactericidal antibodies and hence has also been considered a potential vaccine candidate. In this study, we analyzed the production of NhhA in a large panel of N. meningitidis strains belonging to different serogroups and clonal complexes. We found that trimeric NhhA was produced at different levels by the various strains tested. In some strains belonging to the clonal complex ST41/44, the protein is detectable only as a monomer. Sequencing of the nhhA gene and generation of complementing strains in different genetic backgrounds have proved that a single mutation (Gly to Asp) in the translocator domain affected both trimerization and surface localization of NhhA. In vitro infection assays showed that this mutation impairs meningococcal NhhA-mediated adhesion, suggesting that strains carrying the mutation may rely on different strategies or molecules to mediate interaction with host cells. Finally, we demonstrated that N. meningitidis ST41/44 strains producing the mutated form did not induce killing mediated by NhhA-specific bactericidal antibodies. Our data help to elucidate the secretion mechanisms of trimeric autotransporters and to understand the contribution of NhhA in the evolutionary process of host-Neisseria interactions. Also, they might have important implications for the evaluation of NhhA as a vaccine candidate.
Soot Oxidation Kinetics: A Comparison Study of Two Tandem Ion-Mobility Methods (2013)

The oxidation kinetics of laboratory-generated soot particles has undergone extensive studies because of its importance in combustion-generated emissions and their control. In this study, we employed and compared two tandem ion-mobility methods, a tandem differential mobility analyzer (TDMA) and a differential mobility analyzer–aerosol particle mass analyzer (DMA–APM), to resolve the oxidation kinetics of soot. Whereas the TDMA method measures changes in particle mobility (i.e., size) from which a mass-based reaction rate can be inferred, the DMA–APM is a direct determination of particle mass change. We monitored the structure evolution of soot during oxidation by determining the mass-mobility scaling exponent of the particle population and found that soot structural changes due to oxidative sintering can perturb and corrupt the apparent reaction kinetics extracted from the TDMA method and suggest that the DMA–APM method probably is a more reliable approach to pursue such measurements. By combining the mass change data from DMA–APM with size change data from TDMA, we obtained the material density and primary particle size of soot aggregates during oxidation. Two reaction regimes were identified with oxidation fully penetrating the particle at low temperatures and partial penetration at high temperatures. The activation energies were determined for the two reaction regimes to be 79 and 201 kJ mol–1, respectively. The results should be useful in designing soot oxidation abatement units.
Infrared phase modulators with graded multiple quantum wells (1989)

We investigate the feasibility of a graded multiple quantum well as an infrared phase modulator. The existence of infrared intraband transitions in multiple quantum wells is well known. 1 By applying an external voltage to the well, the wavelength of the transition can be altered. This shifting absorption center induces a corresponding refractive index change of the material, which provides the basis of the electrooptic phase modulator. The introduction of a linear composition gradient in the well causes the well potential to vary across its width. The external voltage also introduces a linear variation in the potential, but now both inside and outside the well. In the absence of a material gradient, the refractive index change is a quadratic function of the voltage. We show that including a built-in composition gradient changes a weak quadratic electrooptic effect into a strong linear one. In particular, for a Ga 1 _ x -Al x As well with AlAs barriers we find the voltage needed for a 180° phase change to be of the order of 150 V, 2 orders of magnitude less than a conventional electrooptic material. The combination of index change linearity and low power consumption makes this structure an excellent candidate as a mid-infrared index modulator.
子どもの経験を階層的に生かす幼小連携カリキュラムの開発(7) : 自然事象に焦点を当てて (2010)

本研究は, 広島大学附属三原幼稚園及び広島大学附属三原小学校での実践を事例として, 幼稚園と小学校低学年の教育内容を子どもの経験の蓄積という観点から見直し, 子どもの経験が階層的に生かされるカリキュラムとして提案することを目的としている。小学校第1・2学年に, 認識の基礎を育成する発見科, 表現力を育成する表現科を, さらに幼稚園年長に「発見・表現の時間」を設定した。本小論では, 今年度は文部科学省の研究開発指定を受けていないため, これまでの発見科, 表現科, 「発見・表現の時間」のカリキュラムの特徴を生かして, 自然事象に焦点を当てて「生活科」の単元開発をした。授業中の子どもたちの発話の検証により, 自分の思いつきや考えを大事にし, 表現し合いながら試行錯誤し, 問題解決に取り組む態度が見られ感覚の意図的使用や試行錯誤の組み入れの効果を確認することができた。また, 単元を実践する際の授業形態については, どの時期にどの内容を個の活動とするかグループでの活動とするか等考え, 計画することが協同しながら問題解決の力を伸ばす上で大切であることが明らかになった。
All-dielectric chiral-field-enhanced Raman optical activity (2021)

Raman optical activity (ROA) is effective for studying the conformational structure and behavior of chiral molecules in aqueous solutions and is advantageous over X-ray crystallography and nuclear magnetic resonance spectroscopy in sample preparation and cost performance. However, ROA signals are inherently minuscule; 3-5 orders of magnitude weaker than spontaneous Raman scattering due to the weak chiral light-matter interaction. Localized surface plasmon resonance on metallic nanoparticles has been employed to enhance ROA signals, but suffers from detrimental spectral artifacts due to its photothermal heat generation and inability to efficiently transfer and enhance optical chirality from the far field to the near field. Here we demonstrate all-dielectric chiral-field-enhanced ROA by devising a silicon nanodisk array and exploiting its dark mode to overcome these limitations. Specifically, we use it with pairs of chemical and biological enantiomers to show >100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurements.