gebhart/patrepeval huggingface dataset:
Data set on Lassa fever in post-conflict Sierra Leone (2019)

Lassa fever is a rodent-borne illness that is endemic to parts of sub-Saharan Africa, including Sierra Leone, Nigeria, and Guinea. The disease is named after the town of Lassa, Nigeria where it was discovered in 1969. This data article focuses on the epidemiology of Lassa fever in Sierra Leone following a decade-long civil war that ended in 2002. The data were collected at Kenema Government Hospital (KGH) in Kenema, Sierra Leone, which maintains the country׳s only Lassa fever treatment facility and a biosafety level 3 (BSL-3) laboratory. The key data set variables include Lassa fever serostatus determined using antigen (Ag), immunoglobulin M (IgM), and immunoglobulin G (IgG) ELISA diagnostic techniques; and patient demographics, survival outcome, and treatment (ribavirin) status. The individual data used to generate the graphs and tables in the corresponding research manuscript published in <i>PLOS Neglected Tropical Diseases</i> in 2014 and its coding guide are provided as Supplementary material (Shaffer et al., 2014) [1].
Dynamic linearity improvement of phase and frequency modulated microwave photonic links using optical lattice filter discriminators (2011)

A phase modulated (PM) microwave photonic link (MPL) with linearity improvement is presented. The link demodulates the PM using a phase discriminator based on a dynamically tunable, integrated, sixth-order optical lattice filter in planar lightwave circuit (PLC) technology. The linearity of the demodulation process is optimized by using electrical spectrum monitoring and a feedback algorithm to automatically choose the filter coefficients. For a 2 GHz modulation frequency, the link achieves a 6.7 dB improvement in the third-order output intercept point (OIP3) for intermodulation distortion (IMD) over a Mach-Zehnder interferometer (MZI).
ChemInform Abstract: Aminoborohydrides. Part 4. The Synthesis and Characterization of Lithium Aminoborohydrides: A New Class of Powerful, Selective, Air‐ Stable Reducing Agents. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Improved Adaptive Power Line Interference Canceller for Electrocardiography (2006)

Power line interference may severely corrupt a biomedical recording. Notch filters and adaptive cancellers have been suggested to suppress this interference. We propose an improved adaptive canceller for the reduction of the fundamental power line interference component and harmonics in electrocardiogram (ECG) recordings. The method tracks. the amplitude, phase, and frequency of all the interference components for power line frequency deviations up to about 4 Hz. A comparison is made between the performance of our method, former adaptive cancellers, and a narrow and a wide notch filter in suppressing the fundamental power line interference component. For this purpose a real ECG signal is corrupted by an artificial power line interference signal. The cleaned signal after applying all methods is compared with the original ECG signal. Our improved adaptive canceller shows a signal-to-power-line-interference ratio for the fundamental component up to 30 dB higher than that produced by the other methods. Moreover, our method is also effective for the suppression of the harmonics of the power line interference.
A Role of Template Surface Charge in the Preparation of Porous and Hollow Particles Using Spray-drying (2009)

Abstract In this paper, the effect of template charge and morphology of particles was studied. Silica nanoparticles (as a model of an inorganic nanoparticle) and differently charged polystyrene (as a model of organic template) were used and self-assembled using a spray-drying method. As a result, particles with porous or hollow structure could be produced when negative or positive zeta-potential template were employed, respectively.
X-band printed rectenna design and experiment for wirelss power transfer (2014)

This paper presents a printed rectenna design and experimental characteristics versus distance between transmitting antenna and the rectenna. The designed rectifier shows 67% of maximum efficiency and 2×2, 4×4 conventional array antennas are connected with rectifier using via hole transition. Within 50cm, 2×2 array rectenna shows higher efficiency and outside the 60 cm, 4×4 array rectenna shows higher efficiency. The maximum efficiencies of two rectennas are 7% and 4%, respectively.
The Effect of Substrate Doping on the Behaviour of a CMOS Electrothermal Frequency-Locked-Loop (2007)

A CMOS electrothermal frequency-locked-loop (FLL) is presented, whose output frequency is determined by the temperature-dependent thermal diffusivity of the silicon substrate. Measurements show that this temperature dependence is essentially process independent. After a batch calibration, the electrothermal FLL has an untrimmed inaccuracy of less than ±0.7°C (3σ) over the temperature range -40°C to 100°C.
Effet du pas de temps sur la simulation d'un système éolien-stockage (2016)

International audience
Abrupt coupling between strongly dissimilar waveguides with 100% transmission (2011)

We present numerical experiments showing how coupled-mode theory can be systematically applied to join very dissimilar photonic crystal waveguides with 100% transmission. Our approach relies on appropriately tuning the coupling of the evanescent tail of a cavity mode to each waveguide. The transition region between the waveguides may be as short as a few lattice spacings. Moreover, this technique only requires varying a small number of parameters (two for each waveguide in our example) and the tuning to each waveguide may be done separately, greatly simplifying the computations involved.
<title>Ultra-low-loss polymeric waveguides for optical interconnection</title> (1997)

AlliedSignal scientists have developed new polymeric materials for ultra-low-loss optical interconnection, particularly for the key wavelengths of 0.83, 1.3, and 1.55 microns. Developments of these materials has required a thorough understanding of fundamental principles of optical absorption due to both vibrational and electronic resonant absorptions. We have thus created materials with measure losses at 830 nm which are in the range of 0.02 dB/cm/ At longer wavelengths, the losses can be higher due to the vibrational absorption within the polymer. However through careful selection of chemical structure, polymeric materials with intrinsic loss below 0.08 dB/cm have been demonstrated at 1.55 micron wavelength. For wavelengths longer than 830 nm, single-mode and multimode waveguides with losses equal to the intrinsic loses have been fabricated.
Impaired Function is a Common Feature of Neuropathy-Associated Glycyl-tRNA Synthetase Mutations (2014)

Charcot-Marie-Tooth disease type 2D (CMT2D) is an autosomal-dominant axonal peripheral neuropathy characterized by impaired motor and sensory function in the distal extremities. Mutations in the glycyl-tRNA synthetase (GARS) gene cause CMT2D. GARS is a member of the ubiquitously expressed aminoacyl-tRNA synthetase (ARS) family and is responsible for charging tRNA with glycine. To date, 13 GARS mutations have been identified in patients with CMT disease. While functional studies have revealed loss-of-function characteristics, only four GARS mutations have been rigorously studied. Here, we report the functional evaluation of nine CMT-associated GARS mutations in tRNA charging, yeast complementation, and subcellular localization assays. Our results demonstrate that impaired function is a common characteristic of CMT-associated GARS mutations. Additionally, one mutation previously associated with CMT disease (p.Ser581Leu) does not demonstrate impaired function, was identified in the general population, and failed to segregate with disease in two newly identified families with CMT disease. Thus, we propose that this variant is not a disease-causing mutation. Together, our data indicate that impaired function is a key component of GARS-mediated CMT disease and emphasize the need for careful genetic and functional evaluation before implicating a variant in disease onset.
Implementation and performance evaluation of a broad-band digital harmonic vector voltmeter (2002)

A broad-band digital harmonic vector voltmeter previously proposed and theoretically studied by the authors was implemented by using a special-purpose random sampling strategy to avoid the bandwidth limitations due to the finite conversion time of the S/H-ADC devices. The experimental results showed that the bandwidth of the instrument is limited only by that of the S/H devices of the acquisition channels, according to the theoretical findings. The maximum amplitude error was not greater than 2%.
A unified approach to lapped orthogonal transforms (1992)

The general conditions of exact reconstruction and a recursive design procedure for lapped orthogonal transform (LOT) with arbitrary length of overlapping are presented. It is shown that LOT can be realized with any standard block transform, discrete cosine transform (DCT), for example, and an additional processing. This processing must also satisfy the same conditions for exact reconfigurations and it may be pretransform processing in the time domain or post-transform processing in the transform domain. In a few examples it is shown that the LOT has a higher coding gain and smaller blocking effects then DCT. With the proposed LOT design procedure, two optimizations, the coding gain maximization and the blocking effect minimization, are presented and compared.
Measurement method of light transmittance of layered metal-dielectric metamaterial (2013)

We propose a measurement method of light transmittance of metamaterials by directly contacting the metamaterial on a Si photodiode. Our measurement method enables direct detection of not only the propagation wave component but also the evanescent wave component through the metamaterial. In this paper, we fabricated a layered metal-dielectric metamaterial composed of Ag/Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> layers on the Si photodiode. The transmittance property of evanescent wave was measured. This result indicates that our measurement system detects evanescent wave transferred through the fabricated metamaterial.
The NIKA2 Sunyaev-Zeldovich Large Program (2024)

The NIKA2 camera operating at the IRAM 30-m telescope excels in high-angular resolution mapping of the thermal Sunyaev-Zel’dovich effect towards galaxy clusters at intermediate and high-redshift. As part of the NIKA2 guaranteed-time, the SZ Large Program (LPSZ) aims at tSZ-mapping a representative sample of SZ-selected galaxy clusters in the catalogues of the Planck satellite and of the Atacama Cosmology Telescope, and also observed in X-ray with XMM-Newton or Chandra . Having completed observations in January 2023, we present tSZ maps of 38 clusters spanning the targeted mass (3 &lt; M 500 /10 14 M ⊙ &lt; 10) and redshift (0.5 &lt; z &lt; 0.9) range. The first in-depth studies of individual clusters highlight the potential of combining tSZ and X-ray observations at similar angular resolution for precised mass measurements under the hydrostatic assumption M HSE . These were milestones for the development of a standard data analysis pipeline to go from NIKA2 raw data to the thermodynamic properties of galaxy clusters for the upcoming LPSZ data release. Final products will include measurements of the mean pressure profile of unprecedented quality and M HSE -observable scaling relation using a distinctive SZ-selected sample, which will be key for ultimately improving the accuracy of cluster-based cosmology.
CaO-based sorbents for CO2 capture prepared by ultrasonic spray pyrolysis (2013)

We report the ultrasonic spray pyrolysis (USP) synthesis and characterization of composite calcium oxide-based sorbents for carbon dioxide capture. Inclusion of a small amount of Al2O3 into the CaO matrix (as low as Al/Ca: 0.03) yielded significant enhancement of resistance to recycling degradation. The effective homogenous dispersion of additives in the CaO matrix and the relatively high surface area materials obtained via USP explain the sorbent's high performance. All materials were characterized by XRD, STEM, TEM, SEM, and TGA (for CO2 uptake measurements). Two common phases of CaAlxOy, Ca12Al14O33 and Ca3Al2O6, were formed during multiple cycles of calcination and CO2 uptake.
Magnetic Resonance Imaging Characteristics of Fibrocystic Change of the Breast (2005)

Although FCC has a wide spectrum of morphologic and kinetic features on MRI, it most often presents as a mass or a nonmass-like regional enhancing lesion with benign enhancement kinetics.
Leflunomide Confers Rapid Recovery from COVID-19 and is Coupled with Temporal Immunologic Changes (2023)

Background: Vaccines for SARS-CoV-2 have been considerably effective in reducing rates of infection and severe COVID-19. However, many patients, especially those who are immunocompromised due to cancer or other factors, as well as individuals who are unable to receive vaccines or are in resource-poor countries, will continue to be at risk for COVID-19. We describe clinical, therapeutic, and immunologic correlatives in two patients with cancer and severe COVID-19 who were treated with leflunomide after failing to respond to standard-of-care comprising remdesivir and dexamethasone. Both patients had breast cancer and were on therapy for the malignancy. Methods: The protocol is designed with the primary objective to assess the safety and tolerability of leflunomide in treating severe COVID-19 in patients with cancer. Leflunomide dosing consisted of a loading dose of 100 mg daily for the first three days, followed by daily dosing, at the assigned dose level (Dose Level 1: 40 mg, Dose Level -1, 20 mg; Dose Level 2, 60 mg), for an additional 11 days. At defined intervals, serial monitoring of blood samples for toxicity, pharmacokinetics, and immunologic correlative studies were performed, as well as nasopharyngeal swabs for PCR analysis of SARS-CoV-2. Results: Preclinically, leflunomide impaired viral RNA replication, and clinically, it led to a rapid improvement in the two patients discussed herein. Both patients completely recovered, with minimal toxicities; all adverse events experienced were considered unrelated to leflunomide. Single-cell mass-cytometry analysis showed that leflunomide increased levels of CD8+ cytotoxic and terminal effector T cells and decreased naïve and memory B cells. Conclusions: With ongoing COVID-19 transmission and occurrence of breakthrough infections in vaccinated individuals, including patients with cancer, therapeutic agents that target both the virus and host inflammatory response would be helpful despite the availability of currently approved anti-viral agents. Furthermore, from an access to care perspective, especially in resource-limited areas, an inexpensive, readily available, effective drug with existing safety data in humans is relevant in the real-world setting.
Channel quantization design in multiuser MIMO systems: Asymptotic versus practical conclusions (2011)

Feedback of channel state information (CSI) is necessary to achieve high throughput and low outage probability in multiuser multi antenna systems. There are two types of CSI: directional and quality information. Many papers have analyzed the importance of these in asymptotic regimes. However, we show that such results should be handled with care, as very different conclusions can be drawn depending on the spatial correlation and number of users. There fore, we propose a quantization framework and evaluate the tradeoff between directional and quality feedback under practical conditions.
Microfabricated thin silicon vapor chamber for low profile thermal management (2017)

This paper presents thermal performance characterization of ultra-thin silicon vapor chambers suitable for integration into packages, including possibly interposers. 720±10 μm thick silicon vapor chambers at three different wick porosities have been fabricated using photolithography and deep reactive ion etching (DRIE) to create chambers, followed by inkjet printing and self-assembly to create patterned bi-porous monolayer copper powder wick structures within the chambers, and finally completed by the use of a low outgassing epoxy to bond the vapor chambers. Vapor chambers were attached with copper tubing using epoxy and were evacuated to 1.2 Pa, prior to charging with de-ionized water. A resistance heater provided heat to the evaporator, and a pin fin heat sink rejected heat to the ambient from the peripheral extension of the vapor chamber. The effect of wick porosity and wick saturation ratio on the performance and reliability of the vapor chambers were studied. Experimental results showed that at a porosity of 0.767, with wick saturation ratio of approximately 50%, the thermal resistance with air cooling was 2.5 K/W, at a heat flux of 7.6 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The lowest thermal resistance of a charged sample was 38% of an uncharged sample's, and was 74% of a 750±25 μm solid silicon substrate's thermal resistance. Testing for 120 hrs showed no significant degradation of the performance of the vapor chambers.
Platform Dependencies in Bottom-up Hydrogen/Deuterium Exchange Mass Spectrometry (2012)

Hydrogen-deuterium exchange mass spectrometry is an important method for protein structure-function analysis. The bottom-up approach uses protein digestion to localize deuteration to higher resolution, and the essential measurement involves centroid mass determinations on a very large set of peptides. In the course of evaluating systems for various projects, we established two (HDX-MS) platforms that consisted of a FT-MS and a high-resolution QTOF mass spectrometer, each with matched front-end fluidic systems. Digests of proteins spanning a 20-110 kDa range were deuterated to equilibrium, and figures-of-merit for a typical bottom-up (HDX-MS) experiment were compared for each platform. The Orbitrap Velos identified 64% more peptides than the 5600 QTOF, with a 42% overlap between the two systems, independent of protein size. Precision in deuterium measurements using the Orbitrap marginally exceeded that of the QTOF, depending on the Orbitrap resolution setting. However, the unique nature of FT-MS data generates situations where deuteration measurements can be inaccurate, because of destructive interference arising from mismatches in elemental mass defects. This is shown through the analysis of the peptides common to both platforms, where deuteration values can be as low as 35% of the expected values, depending on FT-MS resolution, peptide length and charge state. These findings are supported by simulations of Orbitrap transients, and highlight that caution should be exercised in deriving centroid mass values from FT transients that do not support baseline separation of the full isotopic composition.
Adenovirus type 7 penton (2000)

Adenoviral gene therapy vectors suffer from the disadvantages of toxicity and immunogenicity associated with the expression of adenoviral genes from the vector backbone. We report here an alternative strategy for gene delivery that utilizes a single component of the adenoviral type 7 capsid, the penton base (Ad7PB). The Ad7PB gene was sequenced and its amino-acid composition was deduced from its nucleotide sequence. The penton was expressed in Escherichia coli as a soluble C-terminal fusion with glutathione S-transferase (GST-Ad7PB) and was purified by single-step affinity chromatography. Both GST-Ad7PB and cleaved (GST-free) Ad7PB retained the ability to fold into pentamers as observed by electron microscopy. GST-Ad7PB was able to bind a synthetic peptide (FK20) derived from the Ad type 7 fiber and retard DNA through a polylysine chain present at the C-terminus of this linker peptide. GST-Ad7PB was an effective cell transfecting agent when assayed on 293 cells. Transfection was not dependent upon the presence of lysosomotropic agents indicating efficient endosome escape capability. Excess of an RGD-containing peptide derived from Ad7PB was able to inhibit transfection indicating specific integrin-mediated uptake of the GST-Ad7PB-FK20-DNA complexes. We propose that Ad7 pentons can be developed into integrin-specific gene delivery agents.
A low leakage poly-gated SCR device for ESD protection in 65nm CMOS process (2013)

A low-leakage, low triggering polysilicon bounded SCR design is introduced for on-chip electrostatic discharge (ESD) protection in CMOS applications. The advantages of replacing the shallow trench isolation (STI) with a polysilicon gate in the device formation are discussed. The device response to fast transients, emulating ESD CDM-type events, is discussed through VFTLP measurements. The low-leakage characteristics of the SCR clamp are also demonstrated via high temperature measurements.
The electronic structure of oxygen in silicon as revealed by volume visualization of Ab initio calculations (2002)

Volumetric rendering is applied to the interpretation of atomic-scale data generated from quantum molecular dynamics computations. In particular, for silicon computations it is found that volumetric visualization of the computed 3D electronic charge density is a valuable tool for identifying defect states in silicon lattices in which oxygen atoms occur as impurities. Rendering of several judiciously selected ranges of charge density in translucent colors provides an effective means of identifying broken or altered molecular bonds and induced charge excesses in the lattice. The resulting 3D images reveal important features missed previously in 2D charge density contour maps. Stereoscopic 'blink comparison' of image pairs is an extremely valuable way to study the structural differences among various configurations, and animation provides significant insight into the molecular dynamics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cu(II)‐Catalyzed Enantioselective Aldol Condensation Between Malonic Acid Hemithioesters and Aldehydes. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Nonreciprocal Transport in a Rashba Ferromagnet, Delafossite PdCoO2 (2021)

Rashba interfaces yield efficient spin-charge interconversion and give rise to nonreciprocal transport phenomena. Here, we report magnetotransport experiments in few-nanometer-thick films of PdCoO<sub>2</sub>, a delafossite oxide known to display a large Rashba splitting and surface ferromagnetism. By analyzing the angle dependence of the first- and second-harmonic longitudinal and transverse resistivities, we identify a Rashba-driven unidirectional magnetoresistance that competes with the anomalous Nernst effect below the Curie point. We estimate a Rashba coefficient of 0.75 ± 0.3 eV Å and argue that our results qualify delafossites as a new family of oxides for nanospintronics and spin-orbitronics, beyond perovskite materials.
Safety, Pharmacokinetics and Pharmacodynamics of Gs-9620, An Oral Toll-Like Receptor 7 Agonist (2013)

GS-9620 demonstrates safety and pharmacodynamic activity at doses up to 12 mg. Pharmacodynamic activity is seen before adverse events, suggesting the potential for induction of an antiviral response without systemic adverse events in subjects with chronic viral hepatitis.