gebhart/patrepeval huggingface dataset:
Accuracy aware pixel selection in multi-wavelength uDBO metrology enables higher robustness and accuracy for DRAM (2021)

Advancing technology nodes in DRAM continues to drive the reduction of on-product overlay (OV) budget. This gives rise to the need for OV metrology with greater accuracy. However, the ever increasing process complexity brings additional challenges related to metrology target deformation, which could contribute to a metrology error. Typically, an accurate OV measurement involves several engineering cycles for target and recipe optimization. In particular, process optimization in either technology development (TD) phase or high volume manufacturing (HVM) phase might influence metrology performance, which requires re-optimization. Therefore, a comprehensive solution providing accuracy and process robustness hereby minimizing the cycle time is highly desirable. In this work, we report multi-wavelength µDBO enhanced with accuracy aware pixel selection as a solution for robust OV measurement against process changes as well as improved accuracy in HVM. Accuracy aware pixel selection is capable of tackling intra-target processing variations and is established on a multi-wavelength algorithm with immunity to target asymmetry impact. DRAM use cases in FEOL critical layers will be discussed in this paper. Superior robustness and accuracy will be demonstrated together with improved on-product OV performance, promising a process of record metrology solution in specific applications throughout the TD and HVM.
Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension (2018)

Noncirrhotic portal hypertension (NCPH) is a rare disease that may lead to serious clinical consequences. Currently, noninvasive tools for the assessment of NCPH are absent. We investigated the utility of spleen and liver volumetrics as a marker of the presence and severity of portal hypertension in this population. A cohort of NCPH patients evaluated between 2003 and 2015 was retrospectively studied. The association of spleen and liver volumes with the hepatic venous pressure gradient (HVPG) level was evaluated using locally weighted scatterplot smoothing curves. A cohort of patients with viral hepatitis-related liver disease was used as controls. Of the 86 patients with NCPH evaluated during the study period, 75 (mean age, 35 ± 17; 73% males) were included in the final analysis. Patients with portal hypertension had significantly higher spleen and liver to body mass index (BMI) ratios compared to patients with HVPG <5 mm Hg (39.5 ± 27.9 versus 22.8 ± 10.6 cm<sup>3</sup>/kg/m<sup>2</sup>, <i>P =</i> 0.003; 91.1 ± 40.1 versus 71.4 ± 16.7 cm<sup>3</sup>/kg/m<sup>2</sup>, <i>P =</i> 0.014, for spleen/BMI and liver/BMI, respectively). In contrast to the patients with viral hepatitis, a positive linear correlation was observed in the NCPH cohort between spleen/BMI and liver/BMI (above a cutoff of 25 and 80 cm<sup>3</sup>/kg/m<sup>2</sup>, respectively) and HVPG level. Additionally, only in the NCPH cohort was an increase in spleen/BMI range quartile predictive of a higher prevalence of portal hypertension and clinically significant portal hypertension (trend, <i>P</i> = 0.014 and 0.031, respectively). <i>Conclusion:</i> Spleen and liver volumetrics may have utility in the assessment of NCPH as a noninvasive biomarker that can be performed using routine radiologic examinations. Further studies are needed to validate these findings. (<i>Hepatology Communications</i> 2018; 00:000-000).
A Role for the Laminin Receptor in Leukocyte Chemotaxis (1987)

Previous studies on the mechanism of leukocyte traversal of basement membranes showed that rabbit peritoneal exudate polymorphonuclear cells (PMN) preferentially used laminin, a major constituent of basement membrane, to attach to another component, type IV collagen. PMN also responded chemotactically to nanomolar levels of laminin. We have now determined that PMN possess a receptor for laminin. Scatchard analysis using 125I laminin indicates a single class of saturable high affinity binding sites (kd = 6.15 nM/L) on PMN and 3.6 X 10(4) sites per cell. A chymotryptically derived fragment of laminin, C1, which lacks both the long arm and the globular end regions of the short arm (i.e., matrix binding sites) but retains the laminin receptor binding region, gave similar results. Immunoperoxidase studies using monoclonal antibodies to the laminin receptor (mAbLR) indicated the presence of the receptor on the surface of PMN. These cells responded chemotactically to nanomolar levels of C1 and laminin, a result consonant with binding data. PMN chemotaxis to a formyl peptide was markedly inhibited by mAbLR, suggesting that the laminin receptor may be required for PMN chemotaxis in general. Our results suggest that PMN extravasation across basement membranes is aided both by reversible attachment of the cells to laminin in the matrix and by chemotaxis to a gradient of soluble intact and possibly degraded laminin. These characteristics have much in common with those of highly metastatic tumor cells.
A 26-44GHz 28nm CMOS FD-SOI Slow-Wave Tunable Hybrid Coupler for 5G Application (2023)

This paper presents a 26-44GHz multi-band 90° twisted hybrid coupler exhibiting low insertion loss for 5G application. Using a tunable 3-bit slow-wave architecture, the hybrid coupler offers eight operating modes allowing it to select the desired center frequency and covers a bandwidth of more than 51% while minimizing its losses. The hybrid coupler achieves an insertion loss lower than 2.2dB with a minimum of 1.45dB at 26GHz and a phase shift between the two output paths of 95 ± 5°. The circuit is implemented in a CMOS 28nm FD-SOI process and occupies 0.00567 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Long Term Clinical Benefit of Lenalidomide (Revlimid) Treatment in Patients with Myelodysplastic Syndrome without Del 5q Cytogenetic Abnormalities. (2006)

Abstract Background: MDSs are clonal hematopoietic stem cell malignancies characterized by cytopenias resulting from ineffective hematopoiesis. A phase 2 study of lenalidomide (MDS-002) demonstrated hematological improvement in patients with MDS without an associated deletion 5q cytogenetic abnormality (List AF, et al. Haematologica2006;91[suppl1]:379[abst 1032]). We now report multicenter results after 〉2 yrs follow-up. Methods: A total of 214 pts with transfusion-dependent anemia were categorized into the following IPSS MDS risk groups after central review of bone marrow morphology, karyotype, and peripheral blood findings: Low/Int-1 (168 [78%]); Int-2/High (8 [4%]); and unclassified (38 [18%]). Patients were unclassified for missing or inadequate marrow studies for central review (morphology [29] or cytogenetic [7]) or other diagnoses (AML [1], atypical CML [1]). Patients were evaluated for frequency and duration of red blood cell transfusion independence (RBC-TI) (IWG criteria), hemoglobin (Hgb) response, and safety. The starting dose of lenalidomide was 10 mg (daily or daily × 3 wks q28d cycle). Results: Overall, 56 (26%) of 214 enrolled patients achieved RBC-TI. Median time to RBC-TI was 5 wks, median duration of RBC-TI response was 41.0 wks (range, 8.0–136.4), and median Hgb increase achieved during RBC-TI was 3.2 g/dL (range, 1.0–9.8). An additional 36 patients experienced a ≥ 50% reduction in RBC transfusions (overall hematological improvement in 92 [43%] patients). Overall, 47 (22%) patients had an abnormal karyotype at baseline and 9 (19%) patients achieved a cytogenetic response (4 complete). The most common drug-related grade 3/4 adverse events (AEs) were neutropenia and thrombocytopenia (25% and 20%, respectively). Deep vein thrombosis occurred in only 2 (1%) patients. The duration of RBC-TI was ≥ 52 weeks in 21 (38%) patients. Among these 21 patients, 14 (67%) did not require a lenalidomide dose reduction during the first 52 weeks of treatment. Analyses of response variables will be presented. Dose-limiting neutropenia/thrombocytopenia was not reported after 52 weeks. The most commonly reported AEs after 52 weeks were mild-moderate diarrhea and fatigue (38% and 29%, respectively). Conclusion: Lenalidomide is an active, well-tolerated treatment in MDS patients with transfusion-dependent anemia that is not associated with a deletion 5q abnormality. The rate of erythroid hematologic improvement and duration of RBC-TI is encouraging and offers a possible alternative to cytokine therapy.
ChemInform Abstract: Generation of Cation Radicals from Allylic Sulfides and Their Reactions with Silyl Enol Ethers by the Use of Cerium(IV) Ammonium Nitrate. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Navigational Decision Making in Drosophila Thermotaxis (2010)

A mechanistic understanding of animal navigation requires quantitative assessment of the sensorimotor strategies used during navigation and quantitative assessment of how these strategies are regulated by cellular sensors. Here, we examine thermotactic behavior of the Drosophila melanogaster larva using a tracking microscope to study individual larval movements on defined temperature gradients. We discover that larval thermotaxis involves a larger repertoire of strategies than navigation in smaller organisms such as motile bacteria and Caenorhabditis elegans. Beyond regulating run length (i.e., biasing a random walk), the Drosophila melanogaster larva also regulates the size and direction of turns to achieve and maintain favorable orientations. Thus, the sharp turns in a larva's trajectory represent decision points for selecting new directions of forward movement. The larva uses the same strategies to move up temperature gradients during positive thermotaxis and to move down temperature gradients during negative thermotaxis. Disrupting positive thermotaxis by inactivating cold-sensitive neurons in the larva's terminal organ weakens all regulation of turning decisions, suggesting that information from one set of temperature sensors is used to regulate all aspects of turning decisions. The Drosophila melanogaster larva performs thermotaxis by biasing stochastic turning decisions on the basis of temporal variations in thermosensory input, thereby augmenting the likelihood of heading toward favorable temperatures at all times.
Synergy of insulin‐like growth factor‐1 and exercise in amyotrophic lateral sclerosis (2005)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the neuromuscular system resulting in paralysis and ultimately death. Currently, no effective therapy is prescribed for patients; however, several therapeutic strategies are showing promise. Either exercise or treatment with adeno-associated virus/insulin-like growth factor-1 alone has therapeutic benefits in an amyotrophic lateral sclerosis transgenic mouse model. We show here that activity duration affects the therapeutic benefit associated with exercise, with 6- and 12-hour exposure to a running wheel providing significant motor function benefits and increased survival. Remarkably, a combination of insulin-like growth factor-1 gene delivery and exercise has profound effects on survival and function, indicative of synergistic effects with exercise and insulin-like growth factor-1. Our results indicate that a drug treatment in combination with appropriate exercise may provide the most promising therapy for amyotrophic lateral sclerosis to date.
RSOA-based self-seeded transmitters: The ERMES project results and offsprings (2017)

The EU FP7 ERMES project focused on the development of a wavelength division multiplexed passive optical network (WDM PON) colourless self-tuning transmitter based on reflective semiconductor optical amplifiers (RSOAs) self-seeding. These transmitters represent low cost solutions to achieve self-organized wavelength access networks. The EU ERMES project developed self-tuning transmitters both in the C- and O- band with tens of kilometres reach up to 10 Gb/s. During the project we developed different self-seeding architectures with single RSOA exploitation (standard self-seeding) or two-RSOA exploitation (amplified or face-to-face self-seeding). The employment of Faraday rotators and mirrors in retracing configurations ensured polarization insensitive operation of the self-seeded architectures allowing for the exploitation of high gain C and O-band RSOAs, which present a very high polarization dependent gain. The project evaluated the coexistence of time division multiplexing (TDM) and WDM PON supporting high-numbers of users: although the burst mode operation was limited by the build-up time of the long-cavity laser, the rise time is compatible with a sleep mode for energy saving. After the project conclusion self-seeded transmitters have been exploited with alternative modulation formats including polarization division multiplexing and frequency division multiplexing in order to increase the achievable bit rates. Finally further studies to increase modulation cancellation inside self-seeded transmitters have been performed.
Machine Learning Algorithms for Disease Prediction Analysis (2023)

People suffer from a wide variety of diseases due to their environment and lifestyle factors. As a result, early disease prediction becomes critical. On the other hand, making a diagnosis solely on symptoms is too difficult for a doctor. The most difficult challenge is predicting disease accurately. In order to solve this problem, data mining is considered as an important and effective method for disease prediction. Data mining reveals hidden pattern information from massive amounts of medical data derived from disease data. To aid in early diagnosis and treatment, this research work presents a disease prediction prototype to identify potential illnesses based on their symptoms. It reduces the time required to complete the patient’s full diagnosis; additionally, the system’s recommendations can be used to determine the disease. attempts to accurately predict a disease by using machine learning techniques. The proposed system produces results that are up to 87% accurate. This method has enormous potential for more accurately predicting potential diseases. The primary goal of this study is to help nontechnical people and young doctors to make accurate opinions about the disease.
Improving Quantum Dot Light-Emitting Device Efficiency by Charge Balance Enhancement (2017)

QDLEDs promise high color quality displays but their electroluminescence efficiency remains low. In this work, the question of charge balance and its influence on device efficiency is addressed. Approaches to increase efficiency are also presented.
Component Prototypes Towards a Low-Latency, Small-Form-Factor Optical Link for the ATLAS Liquid Argon Calorimeter Phase-I Trigger Upgrade (2015)

This paper presents several component prototypes towards a low-latency, small-form-factor optical link designed for the ATLAS Liquid Argon Calorimeter Phase-I trigger upgrade. A prototype of the custom-made dual-channel optical transmitter module, the Miniature optical Transmitter (MTx), with separate transmitter optical sub-assemblies (TOSAs) has been demonstrated at data rates up to 8 Gbps per channel. A Vertical-Cavity Surface-Emitting Laser (VCSEL) driver ASIC has been developed and is used in the current MTx prototypes. A serializer ASIC prototype, operating at up to 8 Gbps per channel, has been designed and tested. A low-latency, low-overhead encoder ASIC prototype has been designed and tested. The latency of the whole link, including the transmitter latency and the receiver latency but not the latency of the fiber, is estimated to be less than 57.9 ns. The size of the MTx is 45 mm ×15 mm ×6 mm.
Dithianylium Salts as Versatile Reagents for Organofluorine Chemistry: Fluorodesulfuration in the Presence of Various O- and N-Nucleophiles (2002)

Dithianylium salts in combination with oxidative fluorodesulfuration chemistry act as a versatile new class of α,α-difluoroalkylation reagents, allowing for the first time the convenient synthesis of complex α,α-difluoroethers or α-fluoroacetals. Even relatively fragile species, such as α,α-difluoroalkyl azides or peroxides, can be obtained under very mild reaction conditions. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Microwave Heating for the Rapid Generation of Glycosylhydrazides (2013)

Conditions for simple derivatization of reducing carbohydrates via adipic acid dihydrazide microwave-assisted condensation are described. We demonstrate with a diverse set of oligo- and polysaccharides how to improve a restrictive and labor intensive conventional conjugation protocol by using microwave-assisted chemistry. We show that 5 min of microwave heating in basic or acidic conditions are adequate to generate, in increased yields, intact and functional glycosylhydrazides, whereas hours to days and acidic conditions are generally required under conventional methods.
Organising Work and Home in Same‐Sex Parented Families: Findings From the Work Love Play Study (2010)

In this article we present findings from the Work, Love and Play (WLP) study: a survey completed by 445 same‐sex attracted parents across Australia and New Zealand. Comparisons of household division of labour are made between a sub‐sample of WLP participants, who were currently cohabiting with a same‐sex partner ( n = 317), and 958 cohabiting opposite‐sex parents surveyed as part of a major Australian study, Negotiating the Life Course . This comparison showed that same‐sex couples divided household labour significantly more equally than heterosexual parents, and lesbian couples also shared parenting tasks more equally. Qualitative findings from the WLP study indicate that, for many same‐sex couples, major decisions around who gives up paid work and how many hours parents choose to work, as well as decisions around work/family balance, are negotiated on the basis of couple's preferences and circumstance rather than an assumption that one parent will be the primary child carer. It is speculated that this finding highlights an important point of difference between same‐sex couples and heterosexual couples where the division of household labour is often based on the assumption that the mother will almost always be the primary child carer and homemaker. The research is a collaborative partnership between La Trobe University, Deakin University, The University of Melbourne, and Relationships Australia Victoria.
Visualizing the process of interaction in a 3D environment (2007)

As the imaging modalities used in medicine transition to increasingly three-dimensional data the question of how best to interact with and analyze this data becomes ever more pressing. Immersive virtual reality systems seem to hold promise in tackling this, but how individuals learn and interact in these environments is not fully understood. Here we will attempt to show some methods in which user interaction in a virtual reality environment can be visualized and how this can allow us to gain greater insight into the process of interaction/learning in these systems. Also explored is the possibility of using this method to improve understanding and management of ergonomic issues within an interface.
Conformational analysis. 43. A boat-shaped piperidine ring in 3-thia-7-aza-6,8-diphenylbicyclo[3.3.1]nonan-9-ol (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational analysis. 43. A boat-shaped piperidine ring in 3-thia-7-aza-6,8-diphenylbicyclo[3.3.1]nonan-9-olErnest L. Eliel, Muthiah Manoharan, Derek J. Hodgson, Drake S. Eggleston, and R. JeyaramanCite this: J. Org. Chem. 1982, 47, 22, 4353–4356Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/jo00143a041https://doi.org/10.1021/jo00143a041research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A new pipelined decoder of error‐correction codes for a sync‐out data sequence of digital VTRs (1995)

Abstract The error‐correcting decoder is designed assuming that the input data have a constant data length. In the case of digital video technology recorders (VTR), however, there is a possibility that the length of the playback data sequence changes by desynchronization. This paper proposes an independent reset‐type error‐correcting decoder that can cope with the playback data sequence with varying data length. In the independent reset method, the signal indicating the end of processing in the operational block composing the pipeline is used as the reset signal for the operational block in the next stage. By this mechanism, a sufficient time for the operation is secured for each operational block, even if the data length of the input data varies. By applying the proposed method to the D2 digital VTR system, the miscorrection probability is examined. It is then shown that the miscorrection probability can be decreased compared to the conventional method, both in the normal and the special playback. Using the proposed independent reset method, the error‐correcting LSI decoder based on the Reed‐Solomon code is constructed. LSI is shared by the decoding processes of the inner and the outer codes of D2 system. LSI is designed so that up to 4 Bytes can be corrected for both random error and erasure corrections. The additional circuit complexity due to the independent reset mechanism is several percent of the whole LSI.