gebhart/patrepeval huggingface dataset:
Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition (2009)

Gemfibrozil-1-O-beta-glucuronide (GEM-1-O-gluc), a major metabolite of the antihyperlipidemic drug gemfibrozil, is a mechanism-based inhibitor of P450 2C8 in vitro, and this irreversible inactivation may lead to clinical drug-drug interactions between gemfibrozil and other P450 2C8 substrates. In light of this in vitro finding and the observation that the glucuronide conjugate does not contain any obvious structural alerts, the current study was conducted to determine the potential site of GEM-1-O-gluc bioactivation and the subsequent mechanism of P450 2C8 inhibition (i.e., modification of apoprotein or heme). LC/MS analysis of a reaction mixture containing recombinant P450 2C8 and GEM-1-O-gluc revealed that the substrate was covalently linked to the heme prosthetic heme group during catalysis. A combination of mass spectrometry and deuterium isotope effects revealed that a benzylic carbon on the 2',5'-dimethylphenoxy group of GEM-1-O-gluc was covalently bound to the heme of P450 2C8. The regiospecificity of substrate addition to the heme group was not confirmed experimentally, but computational modeling experiments indicated that the gamma-meso position was the most likely site of modification. The metabolite profile, which consisted of two benzyl alcohol metabolites and a 4'-hydroxy-GEM-1-O-gluc metabolite, indicated that oxidation of GEM-1-O-gluc was limited to the 2',5'-dimethylphenoxy group. These results are consistent with an inactivation mechanism wherein GEM-1-O-gluc is oxidized to a benzyl radical intermediate, which evades oxygen rebound, and adds to the gamma-meso position of heme. Mechanism-based inhibition of P450 2C8 can be rationalized by the formation of the GEM-1-O-gluc-heme adduct and the consequential restriction of additional substrate access to the catalytic iron center.
A New Latent Trait Modeling Approach with Contributions to Assessing Latent Unidimensionality and Ability Test Bias (1988)

Abstract : The objectives and progress are summarized with references to reports, unpublished works, and published papers detailing this work. Important accomplishments include: (a) correction of Stout's statistical test of unidimensionality for preasymptotic performance bias, (b) a large scale simulation study suggesting that the statistical test should perform well in applications, (c) development of a new IRT modeling approach capable of assessing the number of dominant latent dimensions and, (d) a rigorous definition of ability test bias and a statistical test of ability test bias. Keywords: Test of unidimensionality, Local independence, Essential unidimensionality, Test bias, Psychological testing.
Two-color-mixed white organic light-emitting diodes with a high color temperature (2011)

Efficient two-color-mixed white organic light-emitting diodes are presented herein by employing a sky-blue phosphorescent dopant of iridium(III)bis[4,6-(difluorophenyl)-pyridinato-N,C 2′]picolinate (FIrpic) and an orange phosphorescent dopant of bis(2-phenylquinoline)(acetylacetonate)iridium(III) (Ir(phq)2acac) on the emissive layer. Very stable color variation under Δ 0.02 until a 5000 cd/m2 brightness value was realized by efficient carrier control in a multi-stacked emitting layer of blue/red/blue colors. Maximum current and power efficiencies of 23.8 cd/A and 22.9 lm/W in the forward direction were obtained. With balanced emission from the two emitters, the white-light emission of high correlated color temperature of 7308 K and the Commission Internationale de I'Eclairage coordinates of (0.30, 0.33) were achieved.
Minimal realization of dynamically balanced lumped mass WA gyroscope: dual foucault pendulum (2015)

We report a new type of MEMS rate integrating gyroscope. The Dual Foucault Pendulum (DFP) gyroscope consists of two dynamically equivalent, mechanically coupled proof masses, oscillating in anti-phase motion, creating a dynamically balanced resonator with x-y symmetry in frequency and damping. Phase synchronization is established by mechanical coupling of the two proof masses, whereas quadrature suppression is achieved by four differential shuttle pairs placed in-between. Dual axis tuning fork behavior provides vibration immunity and anchor loss mitigation, resulting in a Qfactor over 100,000 on both modes at a center frequency of 2.7 kHz. Whole angle mechanization is demonstrated by FPGAbased closed loop control of the gyroscope, showing a scale factor variation of 22 ppm RMS over 2 hours of measurement. We believe Dual Foucault Pendulum is the minimal realization of a dynamically balanced lumped mass whole angle (WA) gyroscope.
Preconditioners for Large Scale-Free Graphs. (2016)

Abstract not provided.
Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted (2012)

Epoprostenol AM has improved thermal stability and does not support the growth of any microorganism tested for up to 14 days. This extended stability under ambient conditions has the potential to improve convenience for patients.
Proposal of New Molecular Characterization Methods in Phylogenetic Studies and Genotypings of Pathogenic Fungi (2008)

Sequence information of 25S rRNA gene was useful for the genotype determination in Candida albicans. Genotypes of 301 C. albicans strains by this single PCR method were determined, and out of them, two strains of new genotype (genotype E) which are closely related to C. dubliniensis in its intron structure were discovered. Analysis of internal transcribed spacer (ITS) region sequence including 5.8S rRNA region in three varieties of C. neoformans was found to be an useful method for genotype determination, and a new genotype (Africa genotype) of var. gattii was discovered. In comparison with other traditional taxonomic methods in pathogenic fungi, usefulness of these genotype determination methods in their epidemiological studies was discussed. New PCR identification systems which were developed based on RAPD band pattern analyses for Histoplasma capsulatum, Paracoccidioides brasiliensis and Penicillium marneffei were also introduced. These genetic studies lead to a development of new DNA microarray identification method, and their usefulness was discussed.
Tensile strength of the medial patellofemoral ligament before and after repair or reconstruction (2005)

The tensile strength of the medial patellofemoral ligament (MPFL), and of surgical procedures which reconstitute it, are unknown. Ten fresh cadaver knees were prepared by isolating the patella, leaving only the MPFL as its attachment to the medial femoral condyle. The MPFL was either repaired by using a Kessler suture or reconstructed using either bone anchors or one of two tendon grafting techniques. The tensile strength and the displacement to peak force of the MPFL were then measured using an Instron materials-testing machine. The MPFL was found to have a mean tensile strength of 208 N (SD 90) at 26 mm (SD 7) of displacement. The strengths of the other techniques were: sutures alone, 37 N (SD 27); bone anchors plus sutures, 142 N (SD 39); blind-tunnel tendon graft, 126 N (SD 21); and through-tunnel tendon graft, 195 N (SD 66). The last was not significantly weaker than the MPFL itself.
The Structure of Sodium Tellurite Glasses: Sodium Cation Environments from Sodium-23 NMR (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Sodium Tellurite Glasses: Sodium Cation Environments from Sodium-23 NMRS. L. Tagg, R. E. Youngman, and J. W. ZwanzigerCite this: J. Phys. Chem. 1995, 99, 14, 5111–5116Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/j100014a035https://doi.org/10.1021/j100014a035research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Has the change to acellular pertussis vaccine improved or worsened pertussis control? (2006)

Between July 1997 and April 1998, all provinces and territories in Canada switched from using a combination vaccine of diphtheria and tetanus toxoids, whole-cell pertussis, inactivated poliovirus and Haemophilus influenzae type b conjugate vaccine (DTwP–IPV–Hib) to a combination vaccine
FTIR spectroscopic determination of soap in refined vegetable oils (2002)

Abstract A new analytical method was developed for the determination of soap in palm and groundnut oils by FTIR spectroscopy. Soap from 0 to 80 mg/kg oil was produced in situ in the oils by adding sodium hydroxide. The FTIR spectroscopy was with a sodium chloride transmission cell, and the partial least‐squares statistical method was used to calibrate a model for each oil. The accuracy of the method was comparable to that of AOCS Method Cc17‐95, with coefficients of determination ( R 2 ) of 0.98 and 0.98 for both palm and groundnut oils. The standard errors of calibration were 1.84 and 1.36 for the two oils, respectively. The calibration models were cross‐validated, and the R 2 of cross‐validation and standard errors of cross validation were computed. The standard deviation of the difference for repeatability of the FTIR method was better than that for the chemical method used for determining soap in palm and groundnut oils. With its speed and ease of data manipulation by computer software, FTIR spectroscopy is a possible alternative to the standard wet chemical methods for rapid (2 min) and accurate routine determination of soap in chemically refined vegetable oils.
A continuously tunable and filterless optical millimeter-wave generation via frequency octupling (2009)

This work proposes a cost-effective, continuously tunable and filterless optical millimeter-wave (MMW) signal generation employing frequency octupling. Optical MMW signals with 30-dB undesired sideband suppression ratios can be obtained. Since no optical filtering is required, the proposed system can be readily implemented in wavelength-division-multiplexing (WDM) systems. V-band 60-GHz and W-band 80-GHz optical MMW signals are experimentally demonstrated. Because of the high undesired sideband suppression ratio, 60-GHz waveform with 50% duty cycle is observed. The single-sideband (SSB) phase noise of the generated 60-GHz signal is -73 dBc/Hz at 10 kHz. The proposed system is a viable solution for the future ultra-high frequency MMW applications up to 320 GHz using the external modulator with a limited bandwidth of 40 GHz.
On the experimental characterization of electromagnetic emissions from printed circuit boards (2002)

An experimental procedure for the characterization of the spurious emissions from printed circuits as a function of the load impedance is presented. The results obtained agree, at least in a qualitative sense, with those predicted by a rigorous spectral domain analysis.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A donor-like trap at the InGaN/GaN interface with net negative polarization and its possible consequence on internal quantum efficiency (2013)

Deep-level transient spectroscopy was performed on InGaN HEMTs and revealed a donor-like trap at the InGaN/GaN interface with net negative polarization. The trap was found to have an energy level of 0.071 eV. A photo-assisted capacitance–voltage (CV) measurement was performed on an InGaN diode. CV curves were measured before and after exposure to a broadband ultraviolet (UV) lamp. The UV lamp caused capacitance to increase as a result of traps being ionized. The trap density was found to be at least 4 × 1011 cm−2.
Deprotonative metallation of ferrocenes using mixed lithium–zinc and lithium–cadmium combinations (2010)

A mixed lithium-cadmium amide and a combination of lithium and zinc amides were reacted with a range of ferrocenes; deprotonative mono- or dimetallation in general occurred chemoselectively at room temperature, as evidenced by subsequent quenching with iodine.
An analysis of extinguishing characteristics of A Cs-Ba tacitron (1992)

The switching frequency, forward conduction drop, and hold‐off voltage determines in which applications the Cs‐Ba tacitron can best be used. Therefore, understanding how the operating conditions affect the above parameters is imperative. This report focuses on the ignition and extinguishing processes of the device and describes how the operating parameters affect the repetition rate. In the Cs‐Ba tacitron, because the degree of ionization is high, most of the heavy components in the interlectrode gap are Cs ions. The removal of ions from the gap allows quenching of the discharge current in the device but makes the subsequent discharge difficult to ignite. When the Cs pressure and/or emitter temperature are increased, the forward conduction voltage drop decreases and ignition becomes easier, but extinguishing becomes much harder because the density of the heavy components in the gap remains higher than its threshold for interrupting the discharge current.
Abstract 2310: With a little help from CD4 T cells in adoptive T-cell transfer (2016)

Abstract Adoptive transfer of genetically engineered T cells offers great opportunities in cancer immunotherapy, however until recently, HLA-Class II-restricted TCRs have been largely ignored. We have identified and cloned HLA class II-restricted CD4+ T cells isolated from patients vaccinated with long peptides derived from antigens such as hTERT, survivin and frameshift mutated TGFβRII. Several of these cancer patients demonstrated outstanding clinical responses to peptide- or dendritic cell based cancer vaccines with &amp;gt;10-year survival. In these patients strong T-cell responses against peptides other than those used for vaccination were detected, suggesting epitope spreading. Responses against certain peptides associated with clinical benefit were identified and CD4+ T-cell clones recognizing such peptides were isolated. In depth studies of their specificities lead to the selection of HLA-DR and -DQ restricted T-cells having high functional avidity for the HLA-peptide complexes. We studied tumor cell and/or protein recognition and found one telomerase-specific CD4+ T-cell clone recognizing a melanoma cell line with the corresponding HLA allele. The TCR sequences of the interesting clones were identified. The ribosome skipping 2A sequence technique was used to express these TCRs in an mRNA expression vector or retrovirus. When expanded T cells were electroporated with these TCRs, both redirected CD8+ and CD4+ T cells produced TNF-α, IFN-γ and the degranulation marker (CD107a) following co-incubation with specific peptide-loaded targets. We have demonstrated that choosing highly functional CD4+ T-cell clones specific for tumor-associated or -specific antigens from patients with clinical responses after immunotherapy treatment is a successful method for identifying highly functional HLA class II restricted TCRs for adoptive T-cell transfer. The use of HLA class II-restricted TCRs may be of therapeutic value both in haematopoietic malignancies and in melanoma where tumor cells often express HLA class II. In addition, combining the redirection of T cells with both HLA class I- and class II-restricted TCRs may provide a more powerful therapeutic effect in adoptive T cell therapy. Citation Format: Else M. Inderberg, Sébastien Wälchli, Marit R. Myhre, Kari Lislerud, Gunnar Kvalheim, Gustav Gaudernack. With a little help from CD4 T cells in adoptive T-cell transfer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2310.
Blue light induced response in the absence of free oxygen (1975)

The absence of oxygen had no effect on the photoinduced conidiation of Trichoderma, a system (unlike previously used systems) where the transient photoinduction and the prolonged respiratory oxygen requirements are separable. The nature of the presumably ubiquitous blue-light absorbing pigment is not restricted to those requiring oxygen.
Elemental Quantification and Visualization of GaN Structures using APT and SIMS (2014)

The in-depth knowledge of focused ion beam (FIB) specimen preparation combined with the sustained development of laser-pulsed atom probe tomography (APT) in the past decade has led to a rapid expansion of applications However, apart from in a limited number of structures, for example dopants of B, P, and As in Si [3], standard protocols for quantification for a broad range of materials have not yet been defined
Microcutting Materials on Polymer Substrates (2002)

The production of micrometer and sub-micrometer features over large areas for use in electronic and optical structures remains challenging, particularly as requirements extend beyond traditional electronic materials to ceramics and polymers. We demonstrate that the technique of microcutting allows patterning of such structures on polymer substrates of these materials as exemplified by the ceramic indium tin oxide (ITO) and the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT). Given the brittleness of most ceramics such as ITO, this is very unexpected, but we find no evidence for microcracking and find high electrical conductivities in narrow tracks (∼2.5 μm) that are separated by less than 500 nm. The micrometer-scale patterns also act as very efficient alignment layers for liquid crystals (LCs), and allow complex alignment patterns.
Resilient Backhaul Network Design Using Hybrid Radio/Free-Space Optical Technology (2015)

The radio-frequency (RF) technology is a scalable solution for the backhaul planning. However, its performance is limited in terms of data rate and latency. Free Space Optical (FSO) backhaul, on the other hand, offers a higher data rate but is sensitive to weather conditions. To combine the advantages of RF and FSO backhauls, this paper proposes a cost-efficient backhaul network using the hybrid RF/FSO technology. To ensure a resilient backhaul, the paper imposes a given degree of redundancy by connecting each node through $K$ link-disjoint paths so as to cope with potential link failures. Hence, the network planning problem considered in this paper is the one of minimizing the total deployment cost by choosing the appropriate link type, i.e., either hybrid RF/FSO or optical fiber (OF), between each couple of base-stations while guaranteeing $K$ link-disjoint connections, a data rate target, and a reliability threshold. The paper solves the problem using graph theory techniques. It reformulates the problem as a maximum weight clique problem in the planning graph, under a specified realistic assumption about the cost of OF and hybrid RF/FSO links. Simulation results show the cost of the different planning and suggest that the proposed heuristic solution has a close-to-optimal performance for a significant gain in computation complexity.
Thermal Performance of a Thin Loop Heat Pipe for Mobile Applications (2016)

This paper describes a new cooling solution for the thermal management of mobile electronics. A thin loop heat pipe (LHP) with a thickness of 0.6 mm for the evaporator was fabricated by using a chemical-etching and diffusion-bonding process for thin copper plates, and it was designed in a size of 107 mm×58 mm to be embedded in a smartphone. The thermal performance of the thin LHP was evaluated under various operating conditions by measuring the temperature, and its effect on the smartphone was demonstrated. The thermal resistance of 0.8 K/W between the thin LHP’s evaporator and condenser was achieved at 5 W, at an evaporator temperature of 50 ℃ in the horizontal operation of the thin LHP, and minimum resistance was 0.12 K/W at 20 W. We confirmed that the performance of the thin LHP slightly depends on its operating orientation.
Data from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity (2023)

&lt;div&gt;Abstract&lt;p&gt;The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages. We developed a retroviral CAR construct specific for the mouse fibroblast activation protein (FAP), comprising a single-chain Fv FAP [monoclonal antibody (mAb) 73.3] with the CD8α hinge and transmembrane regions, and the human CD3ζ and 4-1BB activation domains. The transduced muFAP-CAR mouse T cells secreted IFN-γ and killed FAP-expressing 3T3 target cells specifically. Adoptively transferred 73.3-FAP-CAR mouse T cells selectively reduced FAP&lt;sup&gt;hi&lt;/sup&gt; stromal cells and inhibited the growth of multiple types of subcutaneously transplanted tumors in wild-type, but not FAP-null immune-competent syngeneic mice. The antitumor effects could be augmented by multiple injections of the CAR T cells, by using CAR T cells with a deficiency in diacylglycerol kinase, or by combination with a vaccine. A major mechanism of action of the muFAP-CAR T cells was the augmentation of the endogenous CD8&lt;sup&gt;+&lt;/sup&gt; T-cell antitumor responses. Off-tumor toxicity in our models was minimal following muFAP-CAR T-cell therapy. In summary, inhibiting tumor growth by targeting tumor stroma with adoptively transferred CAR T cells directed to FAP can be safe and effective, suggesting that further clinical development of anti-human FAP-CAR is warranted. &lt;i&gt;Cancer Immunol Res; 2(2); 154–66. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Molecular Imaging of Cardiac Cell Transplantation in Living Animals Using Optical Bioluminescence and Positron Emission Tomography (2003)

The location(s), magnitude, and survival duration of embryonic cardiomyoblasts were monitored noninvasively. With further development, molecular imaging studies should add critical insights into cardiac cell transplantation biology.