gebhart/patrepeval huggingface dataset:
Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens (2016)

Within the EuroVacc clinical trials, we previously assessed the immunogenicity of HIV clade C antigens delivered in a DNA prime/NYVAC boost regimen. The trials showed that the DNA prime crucially improved the responses, and three DNA primes with a NYVAC boost appeared to be optimal. Nevertheless, T cell responses were primarily directed toward Env, and humoral responses were modest. The aim of this study was to assess improved antigens for the capacity to elicit more potent and balanced responses in rhesus macaques, even with various simpler immunization regimens. Our results showed that the novel antigens in fact elicited larger numbers of T cells with a polyfunctional profile and a good Env-GagPolNef balance, as well as high-titer and Fc-functional antibody responses. Finally, comparison of the different schedules indicates that a simpler regimen of only two DNA primes and one NYVAC boost in combination with protein may be very efficient, thus showing that the novel antigens allow for easier immunization protocols.
Performance Testing of the Wireless Sensor Network System for Hurricane Monitoring (2010)

A wireless pressure monitoring system was developed by Florida Institute of Technology to measure wind induced pressure on low-rise structures during hurricanes. This study presents tests made to evaluate the performance of the sensors and their ability to measure accurate pressure variations. To test the reliability of the pressure sensors, a series of tests were designed. The resulting measurements were then compared to secondary references. The measurements were also compared to the basic Bernoulli theory. Further, the wind tunnel measurement allowed for the development of the first comparative computational fluid dynamics simulation and experimental results. Due to the components packaging in the remote, the sensor case cannot be completely streamlined. The resulting shape caused some aerodynamic disturbances. In order to study the sensor shape's influence on the pressure measurements, different experiments were set up. Specifically, by using a roof shaped ramp model mounted on a van, a highway test was performed, allowing examination of the error caused by the sensor's shape. Another test was performed at the University of Florida Hurricane Simulator to study the gust (unsteady) effects. This test revealed that the sensors were sensitive to mechanical vibrations. The paper addresses the sensor network systems topic of the conference.
Runnemede: An architecture for Ubiquitous High-Performance Computing (2013)

DARPA's Ubiquitous High-Performance Computing (UHPC) program asked researchers to develop computing systems capable of achieving energy efficiencies of 50 GOPS/Watt, assuming 2018-era fabrication technologies. This paper describes Runnemede, the research architecture developed by the Intel-led UHPC team. Runnemede is being developed through a co-design process that considers the hardware, the runtime/OS, and applications simultaneously. Near-threshold voltage operation, fine-grained power and clock management, and separate execution units for runtime and application code are used to reduce energy consumption. Memory energy is minimized through application-managed on-chip memory and direct physical addressing. A hierarchical on-chip network reduces communication energy, and a codelet-based execution model supports extreme parallelism and fine-grained tasks. We present an initial evaluation of Runnemede that shows the design process for our on-chip network, demonstrates 2-4x improvements in memory energy from explicit control of on-chip memory, and illustrates the impact of hardware-software co-design on the energy consumption of a synthetic aperture radar algorithm on our architecture.
Treatment Refractory Psychosis Remitted Upon Treatment with Continuous Positive Airway Pressure: A Case Report (2025)

We suggest that this case highlights an issue that might become more common in the future with increasing prevalence of overweight. Indeed, some atypical neuroleptics might even counteract their own therapeutic effect by inducing excessive weight gain that increases the risk for OHS. We recommend taking a careful sleep history in schizophrenic patients with obesity and to perform a polysomnography in suspect cases.
Pathogenese einer akuten hyperkapnischen Hyperammoniämie (1979)

Alterations in the ammonia concentration in arterial blood due to drug-induced portal vasoconstriction (oxprenolol 1 mg/kg) or vasodilatation (phentolamine 0.5 mg/kg) were studied in anaesthetized and artificially respirated mongrel dogs during normal air ventilation, during hypercapnia induced by ventilation with an appropriate gas mixture, and during episodes. The NH3 values in arterial-blood plasma were in the region of 41 microgram/100 ml and those in portal-blood plasma 3--4 times higher. The induction of progressive levels of hypercapnia opened the portal-to-systemic venous shunt, producing an increase in arterial NH3 and, to a lesser extent, NH3 in the CSF. The portal vasoconstriction caused by oxprenolol 1 mg/kg i.v. resulted in the functional elimination of the shunt during normoxia or hypercapnia, leading to a decrease in the NH3 concentration in the arteral blood and hence also in the CSF. The vasodilating effect of phentolamine 0.5 mg/kg i.v., on the other hand, caused a transient, stastically significant increase in arterial NH3 during normoxia; during hypercapnia the NH3 values did not differ from the controls.
Observation and Compensation of Guided Acoustic-Wave Brillouin Scattering in Modulated Channels (2019)

We explore the SNR penalty introduced by GAWBS over trans-oceanic distances. A digital compensation technique is proposed, and its limitations are investigated. In simulations we demonstrate an uncompensated penalty of 0.4 dB after 7000 km.
Insecticide resistance in disease vectors of public health importance (2007)

Vector-borne diseases are a global problem--a trend that may only increase if global temperature rises and demographic trends continue--and their economic and social impact are enormous. Insecticides play a vital role in the fight against these diseases by controlling the vectors themselves in order to improve public health; however, resistance to commonly used insecticides is on the rise. This perspective outlines the major classes of disease vector control agents and the mechanisms of resistance that have evolved, arguing that effective resistance management strategies must carefully monitor resistance in field populations and use combinations of the limited modes of action available to best effect. Moreover, the development of novel insecticide classes for control of adult mosquitoes and other vectors becomes increasingly important.
Mild conversion of carboxamides and carboxylic acid hydrazides to acids and esters (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMild conversion of carboxamides and carboxylic acid hydrazides to acids and estersWilliam J. Greenlee and Eugene D. ThorsettCite this: J. Org. Chem. 1981, 46, 26, 5351–5353Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://doi.org/10.1021/jo00339a019RIGHTS & PERMISSIONSArticle Views1450Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (408 KB) Get e-Alerts Get e-Alerts
Brillouin/erbium fiber lasers (1997)

Brillouin/erbium fiber lasers (BEFLs) have been recently demonstrated as a novel mode of operation of a fiber laser. In a hybrid Brillouin/erbium fiber laser, the combination of two gain media, the gain from the erbium-doped fiber (EDF) and Brillouin gain in single-mode optical fibers allows a resonator to be constructed which supports a laser comb with /spl sim/10 GHz or /spl sim/0.1 nm line spacing at room temperature. In this paper, we present a detailed discussion of the operation of BEFLs. Single and multiple wavelength generation is discussed, and modeling of single wavelength operation is described.
G0200-3-2 Muscle Force Estimation of Individual Forearm Muscles Using Surface Electromyography (2010)

Human hand achieves complex and various actions with cooperative activities of muscles in the forearm. Muscles' activity measurements are available to evaluate the work efficiency of human hands operations and quantify the degree of disease related in the hands. Surface electromyography (EMG) is a generally used method for the measurement using some electrodes attached on the skin surface. Though, for the forearm muscles, the measurement of the activity of individual muscle is difficult because of the superimposition of the EMG signals from muscles, called "cross-talk problem". Previously we developed a muscle analytical system to estimate the individual muscle activity from the surface EMG distributions detected on the skin of forearm. In this study, we apply the system to analyze the synergetic activities of the forearm muscles during the palmar flexion load applying to the carpal joint. The result shows that both the synergetic muscles and antagonist muscles operated against the palmar flexion load. The individual muscle activity could be identified from the surface EMG measurements analyzed in this system.
Data warehouses evolution: trade-offs between quality and cost of query rewritings (1999)

Query rewriting with relaxed semantics has been proposed as a means of retaining the validity of a data warehouse (i.e., materialized queries) in a changing environment. Attributes in the query interface can be classified as essential or dispensable (if it cannot be retained) according to the query definer's preferences. Similarly, preferences for query extent can be specified, for example, to indicate whether a subset of the original result is acceptable or not. The paper discusses the trade-off between quality and cost of query rewriting.
Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation (2022)

<i>Objective</i>. Neural prosthetics often use intracortical microstimulation (ICMS) for sensory restoration. To restore natural and functional feedback, we must first understand how stimulation parameters influence the recruitment of neural populations. ICMS waveform asymmetry modulates the spatial activation of neurons around an electrode at 10 Hz; however, it is unclear how asymmetry may differentially modulate population activity at frequencies typically employed in the clinic (e.g. 100 Hz). We hypothesized that stimulation waveform asymmetry would differentially modulate preferential activation of certain neural populations, and the differential population activity would be frequency-dependent.<i>Approach</i>. We quantified how asymmetric stimulation waveforms delivered at 10 or 100 Hz for 30 s modulated spatiotemporal activity of cortical layer II/III pyramidal neurons using<i>in vivo</i>two-photon and mesoscale calcium imaging in anesthetized mice. Asymmetry is defined in terms of the ratio of the duration of the leading phase to the duration of the return phase of charge-balanced cathodal- and anodal-first waveforms (i.e. longer leading phase relative to return has larger asymmetry).<i>Main results</i>. Neurons within 40-60<i>µ</i>m of the electrode display stable stimulation-induced activity indicative of direct activation, which was independent of waveform asymmetry. The stability of 72% of activated neurons and the preferential activation of 20%-90% of neurons depended on waveform asymmetry. Additionally, this asymmetry-dependent activation of different neural populations was associated with differential progression of population activity. Specifically, neural activity tended to increase over time during 10 Hz stimulation for some waveforms, whereas activity remained at the same level throughout stimulation for other waveforms. During 100 Hz stimulation, neural activity decreased over time for all waveforms, but decreased more for the waveforms that resulted in increasing neural activity during 10 Hz stimulation.<i>Significance.</i>These data demonstrate that at frequencies commonly used for sensory restoration, stimulation waveform alters the pattern of activation of different but overlapping populations of excitatory neurons. The impact of these waveform specific responses on the activation of different subtypes of neurons as well as sensory perception merits further investigation.
A novel capacity maximization scheme for multimedia wireless ATM systems providing QoS guarantees for handoffs (2002)

Wireless ATM (WATM) is expected to provide significantly high bit-rate services to meet the demand for handling multimedia information. In a mobile wireless environment, handoff provisioning is a challenging problem and much effort has been contributed for efficient utilization of the limited radio resources. In this paper, we propose a capacity maximization method in a multimedia wireless ATM system, which can be used for handoff prioritization by bandwidth reservation. Specifically, we propose to regulate the buffer by the selective-delay push-in (SDPI) scheme, and search for the optimal percentage of total bandwidth to be reserved for handoffs. Simulation results show that our scheme significantly improves spectrum efficiency and reduces handoff failure probability.
Skeletal and body composition evaluation (1983)

Research on radiation detectors for absorptiometry; analysis of errors affective single photon absorptiometry and development of instrumentation; analysis of errors affecting dual photon absorptiometry and development of instrumentation; comparison of skeletal measurements with other techniques; cooperation with NASA projects for skeletal evaluation in spaceflight (Experiment MO-78) and in laboratory studies with immobilized animals; studies of postmenopausal osteoporosis; organization of scientific meetings and workshops on absorptiometric measurement; and development of instrumentation for measurement of fluid shifts in the human body were performed. Instrumentation was developed that allows accurate and precise (2% error) measurements of mineral content in compact and trabecular bone and of the total skeleton. Instrumentation was also developed to measure fluid shifts in the extremities. Radiation exposure with those procedures is low (2-10 MREM). One hundred seventy three technical reports and one hundred and four published papers of studies from the University of Wisconsin Bone Mineral Lab are listed.
Compact distributed RLC interconnect models-Part II: Coupled line transient expressions and peak crosstalk in multilevel networks (2000)

For pt. I see ibid., vol. 47, no. 11, (Nov. 2000). Novel compact expressions that describe the transient response of high-speed resistance, inductance, and capacitance (RLC) coupled interconnects are rigorously derived. These new distributed rlc models reveal that peak crosstalk voltage is over 60% larger for 3 GHz high-speed interconnects than predicted by current distributed RC models. Simplified forms of the compact models enable physical insight and accurate estimation of peak crosstalk voltage between two and three distributed RLC interconnects.
Immunosuppression with Cyclosporine during the Incubation Period of Experimental Woodchuck Hepatitis Virus Infection Increases the Frequency of Chronic Infection in Adult Woodchucks (1992)

The immunosuppressive agent cyclosporine was given to adult woodchucks during acute experimental infection with woodchuck hepatitis virus (WHV). All 17 woodchucks given WHV alone or with a vehicle resolved the infection (i.e., zero chronicity), but when cyclosporine was given throughout the incubation and acute phases of infection (0-12 or 14 weeks; n = 12), the rate of chronic infection increased to 92%. When cyclosporine was given only during the incubation period (0-4 weeks; n = 10) or only during the acute phase of infection (2-12 weeks; n = 9), the rates increased to 50% and 55%, respectively. However, when the drug was given after the acute phase (8-18 weeks; n = 9), the chronic infection rate (11%) did not differ from that in untreated and vehicle controls. Immune responses inhibited by cyclosporine are important in resolution of acute WHV infection and occur mainly during the first 8 weeks. Immunosuppression of these responses for even short intervals during incubation (e.g., 0-4 weeks) increases the risk of chronicity.
Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7. (1995)

Modulator is an endogenous low-molecular-weight regulator of both glucocorticoid and mineralocorticoid receptors as well as protein kinase C. Structural analysis of modulator purified to apparent homogeneity suggests that it is a novel ether aminophosphoglyceride. In this report, we show that modulator inhibits cytosolic human glucocorticoid receptor (GR) complex activation as measured by DNA-cellulose binding. In addition, modulator blocks glucocorticoid-induced nuclear translocation of the GR in intact human leukemic (CEM C-7) cells, as illustrated by immunocytochemical localization. Furthermore, we demonstrate that modulator, by blocking the activation and subsequent translocation of GR, inhibits glucocorticoid-mediated apoptosis, characterized by chromatin condensation, internucleosomal DNA fragmentation, and cell death in glucocorticoid-sensitive CEM C-7 cells. Modulator inhibits glucocorticoid-induced c-myc gene repression and glucocorticoid receptor gene up-regulation. These data suggest that modulator functions to regulate the GR in intact cells as well as in cytosolic preparations. In addition, the inhibition of glucocorticoid-induced programmed cell death by modulator sheds light on the cellular function of modulator as well as on the mechanism by which apoptosis occurs in CEM C-7 cells.
Complementary Learning for Overcoming Catastrophic Forgetting Using Experience Replay (2019)

Despite huge success, deep networks are unable to learn effectively in sequential multitask learning settings as they forget the past learned tasks after learning new tasks. Inspired from complementary learning systems theory, we address this challenge by learning a generative model that couples the current task to the past learned tasks through a discriminative embedding space. We learn an abstract generative distribution in the embedding that allows generation of data points to represent past experience. We sample from this distribution and utilize experience replay to avoid forgetting and simultaneously accumulate new knowledge to the abstract distribution in order to couple the current task with past experience. We demonstrate theoretically and empirically that our framework learns a distribution in the embedding, which is shared across all tasks, and as a result tackles catastrophic forgetting.
Supplementary Figure S2 from Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation (2023)

&lt;p&gt;Prodigiosin targets CRCSC self-renewal in vivo.&lt;/p&gt;
Machine Learning-Based Line-Of-Sight Prediction in Urban Manhattan-Like Environments (2023)

This paper considers the problem of predicting whether or not a transmitter and a receiver are in Line-of-Sight (LOS) condition. While this problem can be easily solved using a digital urban database and applying ray-tracing, we consider the scenario in which only a few high-level features descriptive of the propagation environment and of the radio link are available. LOS prediction is modelled as a binary classification Machine Learning problem, and a baseline classifier based on Gradient Boosting Decision Trees (GBDT) is proposed. A synthetic ray-tracing dataset of Manhattan-like topologies is generated for training and testing a GBDT classifier, and its generalization capabilities to both locations and environments unseen at training time are assessed. Results show that the GBDT model achieves good classification performance and provides accurate LOS probability modelling. By estimating feature importance, it can be concluded that the model learned simple decision rules that align with common sense.
3D stacking of Co- and Ni-based microbumps (2016)

In this paper,the wettability, quality of joint formation and electrical yield of daisy chains in 3D stacks when using Cobalt and Nickel as UBM with different finish layers such as immersion Au, ELD NiB, ELD Cu and SAM are investigated. The performance of the stacks are characterized by cross-section SEM images, EDS analysis and electrical resistance measurement of the daisy chains.
Scanning thermal microscope tip-induced chemical reaction on solid organometallic compound thin films (1997)

This article has successfully demonstrated for the first time a chemical reaction induced by a resistive thermal tip. The resulting structures were subsequently imaged by scanning thermal microscopy (SThM) and atomic force microscopy. The thermal conductivity contrast in SThM images suggested that palladium acetate thin film could be decomposed to palladium metal. The resulting palladium metallic features can form down to the substrate and adhere well on the substrate by using thinner precursor palladium acetate film. The effect of control resistance and tip scan rate on resulting features has also been studied. The results obtained indicate the potential application of SThM tip induced chemical reaction in device fabrication.
Template based inter-layer prediction for high dynamic range scalable compression (2015)

This paper presents a scalable high dynamic range (HDR) image coding framework in which the base layer is a low dynamic range (LDR) version of the image that may have been generated by an arbitrary Tone Mapping Operator (TMO). Our method successfully handles the case of complex local TMOs thanks to a block-wise and non-linear approach. A novel template based Inter Layer Prediction (ILP) is designed in order to perform the inverse tone mapping of a block without the need to transmit any additional parameter to the decoder. This method enables the use of a more accurate inverse tone mapping model than the simple linear regression commonly used for block-wise ILP. Our experiments have shown an average bitrate saving of 34% on the HDR enhancement layer, compared to state of the art methods.
Pharmacogenomic Study of Heart Failure and Candesartan Response from the CHARM Programme (2022)

We have identified a candidate genetic variant potentially predictive of the progression of heart failure in patients with preserved ejection fraction. The findings require further replication, and we cannot exclude the possibility that the results may be chance findings.