gebhart/patrepeval huggingface dataset:
Big CPU, Big Data: Solving the World's Toughest Computational Problems with Parallel Computing (2016)

In the twenty-first century, scientists and engineers are tackling the world's toughest computational problems with parallel computing. Using multiple processor cores running simultaneously, parallel computers are solving these problems in less time and with greater accuracy than ever before. Even desktop PCs nowadays are powerful parallel computers. To take full advantage of the capabilities of these machines, programmers must learn to write parallel programs. BIG CPU, BIG DATA teaches you how to write parallel programs for multicore machines, compute clusters, GPU accelerators, and big data map-reduce jobs, in the Java language, with the free, easy-to-use, object-oriented Parallel Java 2 Library. The book also covers how to measure the performance of parallel programs and how to design the programs to run as fast as possible.
Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. (2009)

Abstract Abstract #3020 Background: Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a novel target for breast cancer therapy. We have previously demonstrated that EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity both in vitro and in vivo. EA5, a novel monoclonal antibody that mimicks the binding of ephrin A to EphA2, reverses the effect of EphA2 overexpression and restores tamoxifen sensitivity in EphA2-transfected MCF-7 cells (MCF-7EphA2) in vitro. Here we report the impact of EA5 on in vivo tumor growth and its ability to overcome in vivo tamoxifen resistance in MCF-7EphA2 xenografts. Furthermore, we investigated the mechanisms by which EphA2 overexpression decreases the estrogen dependence and contributes to tamoxifen resistance in ER+ breast cancer models.&amp;#x2028; Material and Methods: MCF-7 cells transfected with vector (MCF-7neo) or EphA2 (MCF-7EphA2) were implanted in the right and left mammary fat pads of athymic mice. Treatment with EA5 (5 mg/kg/i.p./5 days/week), vehicle, tamoxifen (1 mg/oral gavage/5 days/week), or EA5 and tamoxifen in combination was initiated once tumors were established. To explore the role of EphA2 overexpression on ER-dependent mechanisms, we used two different ER+/EphA2-transfected cell line models (MCF-7neo/ MCF-7EphA2 and T47Dneo/ T47DEphA2). We measured ER activity and expression of ER-dependent proteins in response to 17β-estradiol (E2;10-10 M), 4-hydroxy-tamoxifen (10-6 M, and EA5 antibody (3μg/mL). Interaction of ER and EphA2 was investigated using GST-pulldown and co-immunoprecipitation approaches. Gene array studies suggested that EphA2 may impact ER via noncanonical pathways, leading to an investigation of focal adhesion kinase (FAK) signaling.&amp;#x2028; Results: EA5 inhibits primary tumor growth and restores tamoxifen sensitivity in the MCF-7EphA2 in vivo model;EA5 had no impact on in vivo tumor growth in MCF-7neo xenografts. Using T47DEphA2 in vitro model, we verified that EphA2 decreases ER activation in response to E2 stimulation consistent with our earlier results in MCF-7EphA2 model. We found no direct interaction between ER and EphA2 and no difference in expression of canonical ER-dependent proteins, ER coactivators or corepressors. However, E2 stimulation phosphorylates FAKTyr925 in ER+/EphA2+ cell lines but not in ER+/EphA2- cell lines. Treatment of T47DEphA2 cells with EA5 and tamoxifen leads to dephosphorylation of FAKTyr925 in the presence of E2 stimulation.&amp;#x2028; Conclusion: Our data demonstrate that dual targeting of EphA2 and ER is a promising approach for delaying resistance to tamoxifen. The data support our hypothesis that EphA2 impacts ER function via a FAK dependent pathway. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3020.
How a Chemist Looks at RNA (2012)

RNA, just another starting material? Nobel Laureate Tom Cech shows that with an education steeped in kinetics, thermodynamics, and molecular structure, and armed with the ability to synthesize molecules, the chemist is ideally suited to investigate RNA.
A Beginner's View of the The Ekpyrotic Universe (2011)

In 2001, physicists Justin Khoury, Burt Ovrut, Paul Steinhardt, and Neil Turok published “Ekpyrotic universe: colliding branes and the origin of the hot big bang”. In that paper, the authors attempt to explain the origin of the universe, not as the result of the proverbial “big bang”, but rather as the collision of two membranes or “branes”, three-dimensional worlds that exist in a hidden dimension. In this short paper, we contrast the theory of the ekpyrotic universe to the big bang and accompanying inflationary model of the universe as developed in the 1980’s by Steinhardt, Alan Guth, Andre Linde, and Andreas Albrect.
Heterodoped Nanoparticles as Dual-Mode Contrast Agent for MRI (2017)

The purpose of this work is to synthesize Mn-Fe heterodoped ZnSe tetrapod nanocrystals (NCs) as dual-mode MRI contrast agent to offer synergetic beneficial over the single contrast tracer. Also, in vivo feasibility of the Mn-Fe heterodoped ZnSe tetrapod NCs as a dual-mode contrast agent has been studied.
A pharmacokinetic and pharmacodynamic study of flunitrazepam. (1982)

Flunitrazepam was given as an induction agent i.v. to 12 patients undergoing otologic operations. Pharmacokinetics were evaluated from serum samples at 5 min-72 h by 63Ni-EC-GLC. Pharmacodynamic characteristics were estimated subjectively by simple questionnaire and objectively by the anesthetist during and after anesthesia. The dose of flunitrazepam required for anesthesia varied from 14 to 33 (mean 21) micrograms/kg and was not related to age. The mean distribution volumes of flunitrazepam, calculated by the three-compartment open model, were Vd1 0.61 (SD = 0.36) l/kg, Vd2 1.4 (SD = 0.70) l/kg, and Vd3 3.6 (SD = 1.39) l/kg. The mean elimination half-life was 25 h and serum clearance was 94 ml/min. The maximum decreases in blood pressure during anesthesia correlated with the age of the patients. The general assessment of the anesthetist about this form of anesthesia was positive in 75% of the 12 cases. A clear anterograde amnesia was found.
Congenital Aneurysm of the Left Ventricle Associated With Supravalvular Aortic Stenosis and Aneurysm of the Left Main Coronary Artery: Case Report and Review of the Literature (1975)

We report a unique case of a 33 year old female with congenital aneurysm of the left ventricular apex associated with an aneurysm of the left main coronary artery and surgically repaired supravalvular aortic stenosis. The congenital aneurysm of the left ventricular apex was not associated with a midline thoraco-abdominal defect, as reported in the medical literature. The patient survived two episodes of thrombo-embolism and is well after 10 years of medical follow-up.
ChemInform Abstract: Synthesis of Both Enantiomers of Optically Pure Saturated and α,β‐Unsaturated γ‐Substituted γ‐Lactones from Chiral Sulphoxides. X‐Ray Molecular Structure of (3R,4S)‐4‐Methyl‐4‐t‐butyl‐3‐(p‐tolylthio)butanolide and of (3R,4R)‐4‐(Cyclohex‐1‐enyl)‐4‐methyl‐3‐(p‐tolylthio)butanolide. (1986)

Abstract The acids (III) are prepared from the sulphoxides (I); dimetallation produces a chiral homoenolate dianion equivalent which adds to the carbonyl compounds (IV) to give the sulphinyl hydroxy acids (V).
Demonstration of automatic dispersion control for 160 Gbit/s transmission over 275 km of deployed fibre (2004)

The first demonstration of automatic dispersion control suitable for ultra-high-speed 160 Gbit/s transmission over field-deployed fibre is described. Results illustrate the need for adaptive compensation to achieve reliable data transmission at this speed.
Learning to Separate Object Sounds by Watching Unlabeled Video (2018)

Perceiving a scene most fully requires all the senses. Yet modeling how objects look and sound is challenging: most natural scenes and events contain multiple objects, and the audio track mixes all the sound sources together. We propose to learn audio-visual object models from unlabeled video, then exploit the visual context to perform audio source separation in novel videos. Our approach relies on a deep multi-instance multi-label learning framework to disentangle the audio frequency bases that map to individual visual objects, even without observing/hearing those objects in isolation. We show how the recovered disentangled bases can be used to guide audio source separation to obtain better-separated, object-level sounds. Our work is the first to learn audio source separation from large-scale “in the wild” videos containing multiple audio sources per video. We obtain state-of-the-art results on visually-aided audio source separation and audio denoising. Our video results: http://vision.cs.utexas.edu/projects/separating_object_sounds/.
Wederom een geval van hantavirusinfectie in Nederland. (1989)

In a serological survey among Dutch patients suspected of leptospirosis, using a recently developed enzyme-linked immunosorbent assay, a patient was traced with a high antibody titre to Hantaan virus. No anti-leptospira antibodies were detected in this 27-year-old man. Shortly before he had been admitted to the hospital with progressive dyspnoea and coughing, accompanied with high fever. An interstitial pneumonia was diagnosed. He subsequently developed a progressive renal failure with proteinuria and polyuria. Later a liver failure accompanied with thrombocytopenia, anaemia and coagulation disturbances occurred. Before an aetiological diagnosis was made, the patient was treated with erythromycin. The patient eventually recovered completely. Based on the clinical symptoms and the positive serology, it was concluded that the disease diagnosed had probably been caused by a Hantaan virus infection. The diagnostic value of Hantaan virus serology in patients with similar symptoms is stressed.
Modeled and measured mutual impedances, element patterns, and sensitivity for a 19 element focal plane array (2008)

The dipole array has an approximate analytical electrical model, which facilitates the development and testing of signal processing algorithms for the FPA. To verify the accuracy of the analytical approach, we have also modeled the array using the finite element method (FEM). In this paper, we compare the approximate analytical and FEM models to preliminary experimental measurements. Results are given for mutual and self impedances, element patterns for the bare array (no reflector antenna), and the sensitivity of the FPA on the Green Bank 20 Meter Telescope.
Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases (2016)

Cyclin-dependent kinase 5 (CDK5) is a multifunctional serine/threonine kinase that regulates a large number of neuronal processes essential for nervous system development and function with its activator p35 CDK5R1. Upon neuronal insults, p35 is proteolyzed and cleaved to p25 producing deregulation and hyperactivation of CDK5 (CDK5/p25), implicated in tau hyperphosphorylation, a pathology in some neurodegenerative diseases. A truncated, 24 amino acid peptide, p5, derived from p35 inhibits the deregulated CDK5 phosphotransferase activity and ameliorates Alzheimer's disease (AD) phenotypes in AD model mice. In the present study, we have screened a diverse panel of 70 human protein kinases for their sensitivities to p5, and a subset of these to p35. At least 16 of the tested protein kinases exhibited IC50 values that were 250 μM or less, with CAMK4, ZAP70, SGK1, and PIM1 showing greater sensitivity to inhibition by p5 than CDK5/p35 and CDK5/p25. In contrast, the p5 peptide modestly activated LKB1 and GSK3β. A sub set of kinases screened against p35 showed that activity of CAMK4 in the absence of calcium and calmodulin was also markedly inhibited by p35. The Cyclin Y-dependent kinases PFTK1 (CDK14) and PCTK1 (CDK16) were activated by p35 at least 10-fold in the absence of Cyclin Y and by approximately 50% in its presence. These findings provide additional insights into the mechanisms of action for p5 and p35 in the regulation of protein phosphorylation in the nervous system.
Human-robot collaborative handling of highly deformable materials (2017)

Robotic manipulation of highly deformable materials like cloth is a challenging problem due to the high dimensionality and the need for multiple grasped points to fully manipulate the material. Previous methods focused on developing detailed models for the material representation and its interaction with the robot in order to generate a motion plan. In this paper, we expand on our previous work in co-robotic manipulation by considering the collaborative transport of a deformable material by human and a mobile dual-arm robot. Our approach is to first determine optimal position and velocity setpoints from human pose information; the mobile dual-arm robot then attempts to follow these setpoints while satisfying other constraints. The goal is to stably and efficiently transport the material to a desired state. As the human changes his/her pose, the robot determines the relative optimal pose of its end effectors and uses a feedback control law to determine desired end effector velocities. The control signal to the actuators that meets the desired end effector velocities is then calculated according a constrained quadratic program. We evaluate the controller in simulation using the Bullet physics engine to approximate the cloth behavior.
Optimizing large organ scale micro computed tomography imaging in pig and human hearts using a novel air-drying technique (2021)

Abstract Underlying electrical propagation in the heart and potentially fatal arrhythmia is the cardiac microstructure. Despite the critical role of muscle architecture, a non-destructive approach to examine not only myocyte orientation, but cellular arrangement in to laminar organization is lacking in hearts from translational animal models and humans. X-ray micro computed tomography using contrast enhancing agents achieves three-dimensional images at near-histological resolutions. However, imaging large mammalian hearts presents challenges including X-ray over-attenuation and loss of image contrast. The goal of this study was to rethink tissue pre-treatment to optimize, and benefit from micro computed tomography imaging resolution in large tissues. Whole pig and human hearts were dehydrated and perfused with a tissue reinforcing agent, hexamethyldisilazane, and slowly air-dried. Heart morphology was conserved and temporally stable. This enabled direct air-mounting for micro computed tomography imaging. Moreover, the desiccated tissue density was significantly reduced compared to the initial hydrated state (P=0.04). Three-dimensional image reconstructions of air-dried hearts segmented using a single intensity threshold revealed detailed microstructural architecture of myolaminae. Conversely, one-step segmentation of hearts loaded with contrast agents poorly estimated the gross anatomical morphology of the heart and lacked identification of tissue microarchitecture. Air-drying large mammalian hearts optimizes X-ray imaging of cardiac microstructure.
Channel estimation in time-varying flat-fading channel using superimposed pilots with interference avoidance (2010)

Superimposed (SI) pilots have been proposed as an alternative pilot insertion method against conventional time-division multiplexed pilots. Due to the negative effect of non-orthogonal multiplexing of SI pilots, various algorithms have been developed in order to enhance the channel estimation accuracy. Probably the most promising approaches include an additional feedback from pre-detected data symbols. This, however, increases the computational complexity of the receiver. Inspired by some recent studies related to block-transmission scenarios, we propose a novel channel estimation method applicable to narrowband systems. The method is based on preprocessing the signal waveform already in the transmitter. Furthermore, no additional feedback loop is required in the receiver. It is shown by analytic derivations and computer simulations that the proposed approach has considerable benefits over other available methods in the literature.
The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva (2023)

TS improved the sensitivity of all interpreters in detecting emerging or growing ectopic bone lesions in patients with FOP. TS could be applied further, including the areas of systematic bone disease.
Liquid phase oxidations of cyclic alkenes. II (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid phase oxidations of cyclic alkenes. IIDale E. Van Sickle, Frank R. Mayo, and Richard M. ArluckCite this: J. Org. Chem. 1967, 32, 11, 3680–3681Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a090https://doi.org/10.1021/jo01286a090research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thin‐layer chromatography and mass spectrometry coupled using proximal probe thermal desorption with electrospray or atmospheric pressure chemical ionization (2010)

An atmospheric pressure proximal probe thermal desorption sampling method coupled with secondary ionization by electrospray or atmospheric pressure chemical ionization was demonstrated for the mass spectrometric analysis of a diverse set of compounds (dyestuffs, pharmaceuticals, explosives and pesticides) separated on various high-performance thin-layer chromatography plates. Line scans along or through development lanes on the plates were carried out by moving the plate relative to a stationary heated probe positioned close to or just touching the stationary phase surface. Vapors of the compounds thermally desorbed from the surface were drawn into the ionization region of a combined electrospray ionization/atmospheric pressure chemical ionization source where they merged with reagent ions and/or charged droplets from a corona discharge or an electrospray emitter and were ionized. The ionized components were then drawn through the atmospheric pressure sampling orifice into the vacuum region of a triple quadrupole mass spectrometer and detected using full scan, single ion monitoring, or selected reaction monitoring mode. Studies of variable parameters and performance metrics including the proximal probe temperature, gas flow rate into the ionization region, surface scan speed, read-out resolution, detection limits, and surface type are discussed.
Segmented Integer Counter Mode: Specification and Rationale (2000)

We propose a specification for counter mode which is useful for securing packetized media such as network protocols and low-level storage media (e.g., disk sectors). Our specification is simple, yet is flexible enough to adapt to different domains of use. Counter mode is well described in [8], which summarizes its advantages and reviews its security properties.
Alkoxyphenyl Group-Containing Starburst Host Materials for Efficient Blue and Green Organic Light-Emitting Devices (2011)

We designed and synthesized alkoxyphenyl group containing starburst host materials 1. Using 1 as a host material, efficient phosphorescent OLEDs with the power efficiencies of 32lm W-1 for blue, and 85lm W-1 for green at 100cd m-2 were developed.
Figures S1-S6 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα<sup>WT</sup> and ERα<sup>MUT</sup> Breast Cancer (2023)

&lt;p&gt;ESR1 mutants are resistant to endocrine therapies in vitro and in vivo and H3B-5942 can suppress ER pathway activity.&lt;/p&gt;
Sensitized Central Controller of Ventilation in Rats with Chronic Heart Failure Contributes to Hyperpnea Little at Rest but More during Exercise (2006)

Central hypersensitivity alone would not explain hyperpnea at rest in CHF rats. Considering the right and upward shift of V(E) to Pa(CO2) relation, central hypersensitivity contributes more to hyperpnea during exercise. The potential difference between normal and CHF rats in exercise-induced changes in controller and plant should be examined to fully understand the mechanism of exercise hyperpnea and to develop a method to attenuate this.
MiRNAs Derived from Cancer-Associated Fibroblasts in Colorectal Cancer (2019)

Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis.
Physical Properties of Multi-Walled Carbon Nanotube-Filled PVDF Composites Prepared by Melt Compounding (2007)

Abstract Multi-walled carbon nanotube (MWNT)/Poly(vinylidene fluoride) (PVDF) composites with various loading levels (0.01 ∼ 10 wt%) have been prepared by the simple melt-compounding approach. Morphology and electrical properties of the composites were investigated. The experimental percolation threshold for the electrical conductivity was estimated and clearly occurred between 2 and 2.5 wt%. MWNT/PVDF composites presented a shoulder posterior to the main melting peak and an increased endpoint of the peak. In the WAXD profiles, the incorporation of MWNT produced a larger shoulder at 2θ = 20.7° with increase in the loading levels, corresponding to the β-form crystal of PVDF. In the rheological properties, dynamic viscosity, the extent of shear thinning behaviors and relaxation time were notably increased with the MWNT content. Keywords: β-form crystaldynamic viscosityelectrical conductivitymulti-walled carbon nanotubepoly(vinylidene fluoride)