gebhart/patrepeval huggingface dataset:
Internal Resonance Phenomena in Coupled Ductile Cantilevers With Triple Frequency Ratio–Part I: Experimental Observations (2019)

This paper, the first of two companion papers, mainly reports the experimental observations of the internal resonance in a coupled ductile cantilever system from the viewpoint of mass sensing, mass perturbation effect on coupling tongues, and coupling strength effect on the non-linear vibration. In the coupled ductile cantilever system, two geometrically different Cu-based cantilevers, with a frequency ratio of three to one, are coupled by a coupling overhang. A new flow is proposed to determine the bifurcation points (boundary) of coupling range, which is believed to be more suitable for mass sensing under high energy dissipation circumstance. On one hand, the enlargement of the coupling range is founded to be with the increased exciting force, and the lateral leftward shifting of the coupling tongue is observed with increasing the mass perturbation or lengthening the coupling overhang. On the other hand, the enhancement of the coupling strength, by lengthening the coupling overhang, can make the resonant frequency ratio close to the integer one, decrease the area variation of the coupling tongue with mass perturbation, and improve the linearity of mass sensitivity. This implies that the stability of the coupled system might be improved by enhancing the coupling strength. While a mass sensitivity-amplified scheme and its mechanism will be discussed in Part II.
Chains Are More Flexible Under Tension (2010)

The mechanical response of networks, gels, and brush layers is a manifestation of the elastic properties of the individual macromolecules. Furthermore, the elastic response of macromolecules to an applied force is the foundation of the single-molecule force spectroscopy techniques. The two main classes of models describing chain elasticity include the worm-like and freely-jointed chain models. The selection between these two classes of models is based on the assumptions about chain flexibility. In many experimental situations the choice is not clear and a model describing the crossover between these two limiting classes is therefore in high demand. We are proposing a unified chain deformation model which describes the force-deformation curve in terms of the chain bending constant K and bond length b. This model demonstrates that the worm-like and freely-jointed chain models correspond to two different regimes of polymer deformation and the crossover between these two regimes depends on the chain bending rigidity and the magnitude of the applied force. Polymer chains with bending constant K>1 behave as a worm-like chain under tension in the interval of the applied forces f ≤ Kk(B)T/b and as a freely-jointed chain for f ≥ Kk(B)T/b (k(B) is the Boltzmann constant and T is the absolute temperature). The proposed crossover expression for chain deformation is in excellent agreement with the results of the molecular dynamics simulations of chain deformation and single-molecule deformation experiments of biological and synthetic macromolecules.
THz Parallel-Plate Waveguides with Resonant Cavities (2015)

We characterize the terahertz resonance due to a cavity inside a parallel-plate waveguide, and discuss its use for refractive index sensing. Inside the waveguide, we observe a broadband field enhancement associated with this narrowband resonance.
Biaxially Textured YBa2Cu3O7-δ Conductors on Rolling Assisted Biaxially Textured Substrates with Critical Current Densities of 2–3 mA/cm2 (1998)

Epitaxial YBa 2 Cu 3 O 7-δ (YBCO) films with transport critical current densities approaching 3×10 6 A/cm 2 (77 K, 0 T) were fabricated using laser ablation of YBCO onto rolling-assisted biaxially textured-substrates (RABiTS) using a combination of thin CeO 2 and thick YSZ buffer layers. The configuration of the sample was YBCO (∼0.2 µm)/YSZ (0.7 µm)/CeO 2 (0.05 µm)/Ni (125 µm). The CeO 2 and YSZ buffer layers were deposited using electron-beam evaporation and sputtering, respectively. The temperature window for successful pulsed-laser deposition of YBCO onto RABiTS was found to be between 740°C and 790°C.
Immunogenicity and tolerability of personalized mRNA vaccine mRNA-4650 encoding defined neoantigens expressed by the autologous cancer. (2019)

2643 Background: Therapeutic vaccination against cancer has proven very challenging with little clinical benefit. Vaccines against non-viral tumors have mainly targeted differentiation antigens, cancer testis antigens, and over-expressed antigens. However, negative selection in the thymus against these normal non-mutated antigens severely limits the ability to generate high avidity anti-cancer T-cells. The importance of neoantigens to each patient’s unique cancer as targets for immunotherapy has been extensively studied, by our group and others. It is now clear that neoantigen-specific T-cells are present in most cancers and these neoantigens derived from somatic mutations offer a specific and highly immunogenic target for personalized vaccination. We developed a process to identify immunogenic T-cell epitopes derived from tumor-specific mutations using tumor-infiltrating lymphocytes. Methods: We combined, for the first time, validated defined neoantigens, predicted neoepitopes and mutations in driver genes into a single mRNA concatemer (mRNA-4650) to vaccinate patients with metastatic common epithelial cancers. We are conducting a phase I/II trial in patients with metastatic melanoma, gastrointestinal, or genitourinary cancers with at least one lesion that is resectable. Patients must have an ECOG status of ≤1 with adequate organ and bone marrow function. Patients are vaccinated intramuscularly at two-week intervals for four cycles, and dosing may be repeated for a second course of vaccination. Key primary endpoints are safety, tolerability and the development of T-cell reactivity as well as objective response rate. Results: mRNA-4650 is safe at all dose levels studied to date with no reported DLTs or drug related SAEs. Neoantigen specific CD8 and CD4 T cells responses against neoepitopes included in the vaccine have been observed and no tumor regressions were seen. Conclusions: Our data show that such a personalized mRNA vaccination is feasible and can elicit neoantigen specific T cell responses. Combination of vaccines with checkpoint inhibitors or adoptive T cell therapy can open the possibility to develop effective immunotherapies for patients with the common epithelial cancers. Clinical trial information: NCT03480152.
Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp (2013)

Recently, we proposed a model describing the suppression of endogenous glucose production (EGP) during a meal. It assumes that EGP suppression depends on glucose concentration and its rate of change and on delayed insulin action. Hepatic insulin sensitivity (S(I)(Lmeal)) can be derived from EGP model parameters. This model was shown to adequately describe EGP profiles measured with multiple tracer techniques; however, S(I)(Lmeal) has never been compared directly with its euglycemic hyperinsulinemic clamp counterpart (S(I)(Lclamp)). To do so, 62 subjects with different degrees of glucose tolerance underwent a triple-tracer mixed meal. Fifty-seven subjects also underwent a labeled ([3-(3)H]glucose) euglycemic hyperinsulinemic clamp. From the triple-tracer meal data, virtually model-independent estimates of EGP were obtained using the tracer-to-tracee clamp technique, and the EGP model was identified in each subject. Model fit was satisfactory, and S(I)(Lmeal) was estimated with good precision. Correlation between S(I)(Lclamp) and S(I)(Lmeal) was good (r = 0.72, P < 0.001); however, S(I)(Lmeal) was lower than S(I)(Lclamp) (4.60 ± 0.64 vs. 8.73 ± 1.07 10(-4) dl·kg(-1)·min(-1) per μU/ml, P < 0.01). This difference may be due to different ranges of insulin explored during the two tests (ΔI(clamp) = 15.60 ± 1.61 vs. ΔI(meal)= 83.37 ± 10.71 μU/ml) as well as steady- vs. non-steady-state glucose and insulin profiles. In conclusion, the new EGP model provides an estimate of hepatic insulin sensitivity during a meal that is in good agreement with that derived in the same individuals with a hyperinsulinemic clamp. When used in conjunction with the minimal model, the approach potentially enables estimation of hepatic insulin sensitivity from a single-tracer labeled meal or oral glucose tolerance test.
ChemInform Abstract: The Development of CD‐Ring Modified Analogues of 1α,25‐ Dihydroxyvitamin D (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On The Use Of Second- And Higher-order Inverse Statistics (2005)

Inverse higher-order statistics of non-Gaussian, stationary random processes are introduced in this paper, as an extension of their 2nd- order counterparts, known as inverse correlations. Their use in system identification, and specifically in model order determination and parameter estimation problems, is investigated. Estimation procedures are proposed for obtaining sample estimates of inverse statistics and the corresponding (poly)spectra. The algorithms derived are illustrated by simulation examples, involving inverse 2nd- and 3rd-order statistics.
Recombinant beta-serine-interferon in hairy cell leukemia compared prospectively with results with recombinant alpha-interferon (1989)

Ten patients with hairy cell leukemia (HCL) requiring therapy were treated with recombinant beta-serine-interferon (rIFN-beta ser) (90 x 10(6) units [U] subcutaneously three times a week). Eight patients were evaluable for response and nine for toxicity. Five patients (63%) showed normalization of peripheral blood counts, and an additional two patients (25%) showed improvement in at least one hematologic variable. Persistent hairy cells were detected in the bone marrow of all patients at the completion of therapy. All patients experienced influenza-like symptoms which were not dose limiting and which resolved with continued therapy. Erythema and induration at interferon injection sites developed in five patients (56%); one required dose reduction and another was removed from the study for this reason. Data from matched historical controls treated with recombinant alpha-interferon are presented for comparison. We conclude that rIFN-beta ser has activity in HCL.
Integrated methods for production of clean char and its combustion properties. Interim final technical report, September 1, 1992--August 31, 1993 (1993)

The feasibility of using an integrated method consisting of physical coal cleaning, mild gasification (MG) and low temperature oxidation (LTO) to produce chars with SO{sub 2} emissions at least 50% lower than those of their parent coals was studied. MG and LTO studies were conducted in both a batch fluidized-bed reactor (FBR) and in continuous feed reactors. Combustion properties of coal-char blends were determined at the US EPA in a 14 kW pilot-scale combustor and ash deposition behaviors of selected fuels were determined at UNDEERC in a drop tube furnace (DTF) . This project was cost-shared with the US EPA and the US DOE through UNDEERC. MG chars were prepared from six different coals in the FBR. Under non-optimized conditions, desulfurized chars with SO{sub 2} emissions 60--71% lower than the parent coals were made, depending on the coal. Chars prepared from four of the six coals had SO{sub 2} emissions less than 2.5 lbs SO{sub 2}/MMBtu. Treatment of a high chlorine coal reduced its chlorine content over 93%. Optimization of process conditions revealed that the greatest reduction in SO{sub 2} emissions was obtained using smaller particle diameters, steam during both MG and LTO, a higher temperature and higher oxygen partial pressure. For the only coal tested under optimized conditions, SO{sub 2} emissions were reduced nearly 67%, from 4.60 to 1.49 lbs SO{sub 2}/MMBtu. Over 150 pounds of chars were prepared in the continuous feed reactors. A total of about 350 pounds of different coal-char blends were prepared for tests at the US EPA. These tests were completed July 31 and the results are currently being analyzed. Results of ash deposition tests at UNDEERC will be available for the final report.
Plasticizer migration from PVC cable insulation - a case study testing different extrapolation methods (2013)

Plasticizer migration from PVC cable insulation - a case study testing different extrapolation methods
New Design of Control System for Transmission Press (2006)

This paper introduces a new design of control system for transmission press.And it gives the description of the hardware configuration,control function and realization.The transmission press is a mechatronics machine which belongs to the transmission assembly line.The machine has automatic press function, automatic detection and alarm function.Additionally,it can communicate with assembly management system in order to achieve the function of management and control.The whole system adopts control components such as SLC500 programmable controller,touch screen,safety light curtain etc.Then safety and reliable assembly quality is ensured.
Hormonal Regulation of Testicular Descent: Experimental and Clinical Observations (1977)

Hormonal regulation of testicular descent has been investigated. Based on experimental studies using the rat and on a review of clinical material it has been determined that testicular descent is an androgen-mediated event directly under the regulation of pituitary gonadotropin. Furthermore, the active androgenic metabolite involved in this process appears to be dihydrotestosterone, which is synthesized by the testis and must be present in high local concentrations to be effective. In addition to these hormonal requirements the anatomy of the inguinal canal must provide unimpeded migration of the testis into the scrotum. Any imbalance or anomaly of these prerequisites may lead to cryptorchidism.
Reduction of lateral phosphorus diffusion in CMOS n-wells (1990)

It is shown that it is possible to control lateral diffusion of phosphorus during an n-well drive-in through appropriate choices of surface thin-film and drive-in conditions. This permits reduced design rules with no change in lithography. The n-well drive-in process takes advantage of vacancy supersaturation caused by SiO formation. In an n-well structure, vacancies are injected only outside the well region, from the thin oxide, and virtually no vacancies are injected from the thick SiO/sub 2/-Si interface. Therefore, while normal P diffusion in the vertical direction in the well is still expected, lateral diffusion of P into the region under the thin oxide can be retarded.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function (2016)

Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is also required for neuronal network functions in murine brain, but neuronal ADAM10 substrates are only partly known. With a proteomic analysis of Adam10-deficient neurons we identified 91, mostly novel ADAM10 substrate candidates, making ADAM10 a major protease for membrane proteins in the nervous system. Several novel substrates, including the neuronal cell adhesion protein NrCAM, are involved in brain development. Indeed, we detected mistargeted axons in the olfactory bulb of conditional ADAM10-/- mice, which correlate with reduced cleavage of NrCAM, NCAM and other ADAM10 substrates. In summary, the novel ADAM10 substrates provide a molecular basis for neuronal network dysfunctions in conditional ADAM10-/- mice and demonstrate a fundamental function of ADAM10 in the brain.
Spirobifluorene modified electron transport materials for high efficiency in phosphorescent organic light-emitting diodes (2022)

Spirobifluorene modified materials developed as electron transport layers lowered device driving voltage, enhanced quantum efficiency, and more than doubled the lifetime of green phosphorescent organic light-emitting diodes.
Defects of the Lamina Cribrosa in High Myopia and Glaucoma (2015)

High myopia and glaucoma significantly increased the risk of LC damage. The LC damage in non-glaucomatous highly myopic eyes may at least partly explain the increased risk of developing glaucoma in myopic eyes.
Low-Density Parity-Check Codes for ATSC 3.0 (2016)

In this paper, we introduce the overview and detailed structure of low-density parity-check (LDPC) codes, which are adopted for the physical layer standard of Advanced Television Systems Committee (ATSC) 3.0. As one of the features to mitigate channel errors efficiently, LDPC codes are used as a main part of forward error correction scheme within the bit interleaved coded modulation chain. This paper presents two different structures of LDPC codes in the ATSC 3.0 standard: 1) irregular repeat accumulate structure and 2) multi-edge type structure. After the detailed encoding methods for the two structures are introduced, the performance results including comparison studies with other broadcasting standards such as DVB-T2 and DVB-S2 are shown.
Fundamental asymmetries between spatial and temporal boundaries in electromagnetics (2022)

Time-varying materials bring an extra degree of design freedom compared to their conventional time-invariant counterparts. However, few discussions have focused on the underlying physical difference between spatial and temporal boundaries. In this letter, we thoroughly investigate those differences from the perspective of conservation laws. By doing so, the building blocks of optics and electromagnetics such as the reflection law, Snell's law, and Fresnel's equations can be analogously derived in a temporal context, but with completely different interpretations. Furthermore, we study the unique features of temporal boundaries, such as their nonconformance to energy conservation and causality.
Clinical magnetic resonance imaging of the vascular system (1990)

Magnetic resonance imaging is extremely well suited to the diagnostic evaluation of the cardiovascular system. Over the past few years, more effective pulse sequences for imaging the heart and blood vessels have been developed, and although clinical use of cardiac MRI remains limited the use of MR angiographic techniques to evaluate major blood vessels is one of the fastest growing clinical applications of MRI today. The article reviews the current indications for vascular MRI with emphasis on those that are increasingly accepted by referring clinicians.
Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity (2014)

The EGF receptor (EGFR) is amplified and mutated in glioblastoma, in which its common mutation (ΔEGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect. This range of activities suggested to us that ΔEGFR might exert its influence through pleiotropic effectors, and we hypothesized that microRNAs might serve such a function. Here, we report that ΔEGFR specifically suppresses one such microRNA, namely miR-9, through the Ras/PI3K/AKT axis that it is known to activate. Correspondingly, expression of miR-9 antagonizes the tumor growth advantage conferred by ΔEGFR. Silencing of FOXP1, a miR-9 target, inhibits ΔEGFR-dependent tumor growth and, conversely, de-repression of FOXP1, as a consequence of miR-9 inhibition, increases tumorigenicity. FOXP1 was sufficient to increase tumor growth in the absence of oncogenic ΔEGFR signaling. The significance of these findings is underscored by our finding that high FOXP1 expression predicts poor survival in a cohort of 131 patients with glioblastoma. Collectively, these data suggest a novel regulatory mechanism by which ΔEGFR suppression of miR-9 upregulates FOXP1 to increase tumorigenicity.
Data from Ubiquitin-Proteasome System Stress Sensitizes Ovarian Cancer to Proteasome Inhibitor–Induced Apoptosis (2023)

&lt;div&gt;Abstract&lt;p&gt;The ubiquitin-proteasome system (UPS) mediates targeted protein degradation. Notably, the UPS determines levels of key checkpoint proteins controlling apoptosis and proliferation by controlling protein half-life. Herein, we show that ovarian carcinoma manifests an overstressed UPS by comparison with normal tissues by accumulation of ubiquitinated proteins despite elevated proteasome levels. Elevated levels of total ubiquitinated proteins and 19S and 20S proteasome subunits are evident in both low-grade and high-grade ovarian carcinoma tissues relative to benign ovarian tumors and in ovarian carcinoma cell lines relative to immortalized surface epithelium. We find that ovarian carcinoma cell lines exhibit greater sensitivity to apoptosis in response to proteasome inhibitors than immortalized ovarian surface epithelial cells. This sensitivity correlates with increased cellular proliferation rate and UPS stress rather than absolute proteasome levels. Proteasomal inhibition &lt;i&gt;in vitro&lt;/i&gt; induces cell cycle arrest and the accumulation of p21 and p27 and triggers apoptosis via activation of caspase-3. Furthermore, treatment with the licensed proteasome inhibitor PS-341 slows the growth of ES-2 ovarian carcinoma xenograft in immunodeficient mice. In sum, elevated proliferation and metabolic rate resulting from malignant transformation of the epithelium stresses the UPS and renders ovarian carcinoma more sensitive to apoptosis in response to proteasomal inhibition. (Cancer Res 2006; 66(7): 3754-63)&lt;/p&gt;&lt;/div&gt;
Synthesis of Isoindole Derivatives by Palladium-Catalyzed Domino Reaction of (2-Alkynyl)phenylketone O-Pentafluorobenzoyloximes (2011)

Isoindole derivatives were synthesized by the palladium-catalyzed cyclization of (2-alkynyl)phenylketone O-pentafluoro­benzoyloximes in the presence of organometallic compounds such as sodium formate and aryl boronic acid.
Intracavity laser tomography of C_2 in an oxyacetylene flame (1981)

C(2) may play an important role in soot formation in some flames and is a major species in acetylene combustion chemistry. In this Letter the technique of intracavity spectroscopy has been combined with a simple tomographic analysis to measure spatially resolved C(2)-concentration profiles in an oxyacetylene flame. We find that ground-state and excited-state C(2) are located in the same region of the flame, suggesting that conditions required for their formation are the same. Our results indicate that the C(2) concentration in the mantle region is close to its equilibrium value.
Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study (2017)

ClinicalTrials.gov, study number: NCT00998556.
Supplementary Figure 3 from Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth (2023)

&lt;p&gt;PDF file, 1238K, Effect of the pPB-HSA-IFNγ conjugate on the infiltration of inflammatory cells in tumors (CD68+, CD4+ and CD8+ cells) and livers (CD68+).&lt;/p&gt;