gebhart/patrepeval huggingface dataset:
Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. (2009)

68 subjects completed the 12-week study. No statistically significant differences from baseline scores were indicated at the Post-Scaling Examinations for either the Test Paste or Control Paste groups. Immediately following product application and 4 weeks after product application, subjects assigned to the Test Paste group exhibited statistically significant improvements from baseline with respect to baseline-adjusted mean air blast (44.1% and 45.9% respectively) and mean tactile hypersensitivity scores (156.2% and 170.3% respectively). At the same time points, subjects assigned to the Control Paste group exhibited statistically significant improvements from baseline with respect to baseline-adjusted mean air blast (15.1% and 8.9% respectively) and mean tactile hypersensitivity scores (43.1% and 8.3% respectively). Immediately following application of the assigned paste and 4 weeks later, the Test Paste group demonstrated statistically significant reductions in dentin hypersensitivity with respect to baseline-adjusted mean air blast (34.1% and 40.6% respectively) and mean tactile hypersensitivity scores (79.0% and 149.6% respectively), compared to the Control Paste group. No statistically significant differences were exhibited between paste groups at the Post-Scaling and 12-week examinations with respect to mean tactile and baseline-adjusted mean air blast hypersensitivity scores.
Assessment of local blowing and suction in a turbulent boundary layer (2002)

Effects of local blowing or suction from a spanwise slot on a turbulent boundary layer flow are investigated using the direct numerical simulation technique. Three different blowing or suction velocities are imposed on the slot keeping blowing or suction flow rate constant. The recoveries of mean wall pressure for the different blowing velocities collapse well on the same recovery line. However, each wall pressure recovers just after the slot for suction. In the blowing case, the relaxation of rms wall pressure fluctuations and pressure gradient after the slot is seen and the relaxation distance from the slot center is nearly constant for three different blowing velocities. In the suction case, the flow recovers from the immediate rear of the slot. These features are also observed in three-dimensional views of the near-wall vortices.
Signature Genes for Type 2 Diabetes in an African American Population (2021)

BACKGROUND AND AIM: Diabetes disproportionately affects racial/ethnic minority populations. Type 2 Diabetes Mellitus (T2DM) is viewed as an outcome of the interaction of environmental and biological risk factors. Our previous studies established the biomarkers (genes) of T2DM-related biological pathways in Caucasian and Asian populations. This present work aims to investigate on T2DM-related metabolic pathways in a diabetic African American population. METHODS: RNAs were extracted from blood samples of an African American (AA) population (n=48 Diabetic-cases) compared to Calibrator (matched non-diabetic-Controls; Male/Female) recruited in Washington DC, between the ages of 45-65 years; High-throughput Taqman Low Density Array (TLDA) provided analysis of differential gene expression. We used a custom array containing genes (24 transcripts) related to diabetes and metabolic dysfunction. RESULTS:Differential gene expression analysis revealed distinct differences in T2DM compared to controls in the AA population. 90% of the 24 genes were downregulated in the participants with T2DM, including INSR, ARNT, CYP2D6, RRAD, IL6, HNF1B, INS, and SLC2A2, which are associated with dysregulated homeostasis and xenobiotic metabolism. CONCLUSIONS:The importance of gene-environment (GxE) interactions lies not only in a better understanding of the complex interplay of genetic and environmental risk factors relevant to human diseases; the identification of GxE can also influence risk prediction and identify subgroups of individuals that are most genetically susceptible developing diabetes. The results obtained here contrast with our previous results and therefore tend to confirm the GxE model. Further large-scale population validation with the addition of gender- age, smoking, and other epigenomic conditions may further delineate the sensitivity of relative gene expressions in fine tuning towards clinical application of these markers. KEYWORDS: Exposures, Obesity & Metabolic Disorders, Omics Technologies
High-Density and Low-Power Nonvolatile Static Random Access Memory Using Spin-Transfer-Torque Magnetic Tunnel Junction (2012)

A novel nonvolatile static random access memory cell is proposed that consists of four transistors and two spin-transfer-torque magnetic tunnel junctions (STT-MTJs). In the case of the NFET driver cell, the free layers of the magnetic tunnel junctions are connected to the transistors' sources and drains to make the cell read-disturb free. The static power is totally eliminated as the power line is shut down during data hold. The static noise margin of the cell is calculated based on the experimental data on MTJ switching that is enhanced from the resistive load SRAM cell due to the MTJ's switching operation. The cell size is estimated to become smaller than the 6-transistor SRAM cell when it is designed at 45 nm node and beyond owing to the MTJ's area shrink as well as the thinning of its tunnel dielectrics (MgO).
17a-Oxa-17a-homobrassinosteroid Analogues (1998)

Synthesis of a 17a-oxa-17a-homobrassinosteroids, i.e. brassinosteroids having two lactone rings, is described. In the bean second internode bioassay, dilactone 16 was the most effective of the compounds synthesized. In the same test, the castasterone analogue 12 exhibited a growth-retarding effect.
Session details: PAPER SESSION 5: Interaction in Contexts (2016)

No abstract available.
Synthesis, Structural Analysis and Application of Aryl‐Diadamantyl Phosphine ligands in Palladium Catalyzed Cross‐Coupling Reactions (2020)

We would like to highlight that reference 111 in our original article2 describes one example of the para substituted ligands. The morpholino derivative was prepared by Stradiotto and co-workers and its reactivity was compared to the Mor-DalPhos ligands in Buchwald–Hartwig amination. The Authors
Simultaneous Optimal Design Method of Primary Radiator and Main Reflector for Shaped Beam Antennas (2017)

Shaped beam reflector antennas are widely used because they can achieve a shaped beam even with a single primary feed. Because coverage shapes depend on service areas, optimum primary radiators and reflector shapes are determined by the service areas. In this paper, we propose a simultaneous optimal design method of the primary radiator and reflector for the shaped beam antenna. Particle swarm optimization and the conjugate gradient method are adopted to optimize the primary radiator and reflector. The design method is applied to Japan coverage to verify its effectiveness.
High-power laser power measurement based on principle of light pressure (2022)

大功率激光功率测量常用量热法，但溯源复杂。介绍了具有较高测量精度的基于光压原理的大功率激光功率测量方法，设计了利用1/10<sup>5</sup>精度天平大功率激光测量实验，测试了基于GaAs半导体材料制作的反射镜的反射率及损伤阈值，确定了基于GaAs半导体材料反射镜的相关性能。得到了普通实验室条件下的功率测量重复性及线性，验证了1/10<sup>5</sup>精度天平用于大功率激光测量的可行性。通过实验结果结合理论计算，得出利用1/10<sup>5</sup>精度天平的光压测量功率的测量上限可以达到3×10<sup>4</sup> W以上。
Advanced wide field of view millimeter-wave radar using orthogonal complementary codes (2014)

This paper reports a radar system design using 79GHz millimeter-wave for vehicular and pedestrian safety around intersections. The proposed system design and associated key algorithms are embedded into a prototype and verified in an anechoic chamber and a field experiment. The system covers the distance of 40m and the azimuth angle of 120° range with high range and angular resolution (20cm, 5-degree), and can detect pedestrians within short budget of 100ms by using orthogonal complementary codes which are transmitted by Tx dual beamscanning to suppress the interference between the two divided area. The results therefore prove the system feasibility for future automotive safety application.
Supplemental Table 1 from Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain (2023)

&lt;p&gt;Supplemental Table 1. MS intensity value (MSIV per 1.0Ã—106 cells) of 13C labeled metabolites shown in Figure 5D-5N&lt;/p&gt;
Integrating surface nanotextures into thin crystalline-Si solar cells: The case of a 1-μm-thin nanoimprinted heterojunction cell (2016)

Texturing of crystalline silicon at the light wavelength scale is a promising approach for light management in ever thinner cells. However, this approach requires adapting the device design and process, which has so far revealed to be a challenging task. Indeed, successful integration requires compromising the excellent optical properties for preserving the electrical ones. We briefly summarize what has been learned so far in the community and illustrate some of these learnings with the fabrication and improvement of 1-μm-thin monocrystalline nanotextured silicon solar cells.
An autonomous distributed demand-side energy management network using fluorescent lamp sensors (2008)

This paper demonstrates the building blocks of a new autonomous demand-side energy management system. The system uses a network of lamp sensors interfaced with frequency-controlled dimming ballasts. The auto-dimming lamps detect occupants and automatically adjust their own brightness levels. These occupancy detections may be used to adjust power consumption of other systems such as heating, ventilation and air-conditioning (HVAC) as well. This paper also demonstrates a quasistatic frequency-modulated (FM) wireless link to network auto-dimming lamps with each other. The wireless link reuses the frequency-controlled action of the dimming ballast to transmit data and the lamp sensor electric field measurement to receive data. All of the electronics are made to fit inside a ballast box with the intent to create a drop-in replacement for standard ballasts. This paper presents critical system characterizations and design strategies as well as a demonstration of an auto-dimming lamp and the wireless link.
Asymmetric Total Synthesis of (+)-Luciduline: Toward a General Approach to Related Lycopodium Alkaloids (2011)

As part of a research program directed toward the synthesis of Lycopodium alkaloids, a multigram scale asymmetric synthesis of intermediate 11 was achieved in 11 steps from pyridine (17). In addition to our alkene metathesis strategy, a key feature of this synthetic approach consists of a Fukuyama's Diels-Alder cycloaddition between 1,2-dihydropyridine and acrolein using MacMillan's catalyst (18) on a 50 g scale. This led to a 12-step catalytic asymmetric synthesis of (+)-luciduline (1). A broader subset of Lycopodium alkaloids could also be obtained, as demonstrated by the derivatization of 11 into advanced intermediates for the synthesis of some of these natural products.
How Does Body Mass Index Influence Outcomes in Patients After Lumbar Fusion? (2019)

3.
Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants (2021)

Instrumented implants are being developed with a radically innovative design to significantly reduce revision surgeries. Although bone replacements are among the most prevalent surgeries performed worldwide, implant failure rate usually surpasses 10%. High sophisticated multifunctional bioelectronic implants are being researched to incorporate cosurface capacitive architectures with ability to deliver personalized electric stimuli to peri-implant target tissues. However, the ability of these architectures to detect bone-implant interface states has never been explored. Moreover, although more than forty technologies were already proposed to detect implant loosening, none is able to ensure effective monitoring of the bone-implant debonding, mainly during the early stages of loosening. This work shows, for the first time, that cosurface capacitive sensors are a promising technology to provide an effective monitoring of bone-implant interfaces during the daily living of patients. Indeed, in vitro experimental tests and simulation with computational models highlight that both striped and circular capacitive architectures are able to detect micro-scale and macro-scale interface bonding, debonding or loosening, mainly when bonding is weakening or loosening is occurring. The proposed cosurface technologies hold potential to implement highly effective and personalized sensing systems such that the performance of multifunctional bioelectronic implants can be strongly improved. Findings were reported open a new research line on sensing technologies for bioelectronic implants, which may conduct to great impacts in the coming years.
Supplementary Figures 1 - 2, Table 1 from A Multiantigen Vaccine Targeting Neu, IGFBP-2, and IGF-IR Prevents Tumor Progression in Mice with Preinvasive Breast Disease (2023)

&lt;p&gt;PDF file - 3266K, Supplemental Figure 1. Protein expression of vaccine component antigens in preinvasive lesions derived from TgMMTV-neu mice. Supplemental Figure 2. Multi-antigen peptide vaccine controls tumor growth in a TgC3(I)-Tag implant model. Supplemental Table 1. Vaccine component peptides.&lt;/p&gt;
for a High Through-Put Vitamin D 1, 25-Dihydroxy Assay (2000)

The Vitamin D 1, 25-Dihydroxy assay has a testing through-put in excess of 20,000 samples a month. The assay is performed in two parts, the first comprising of protein precipitation of serum or plasma followed by solid phase extraction (SPE) and purification of the Vitamin D 1, 25-Dihydroxy on C18OH columns. The second half is a competitive RIA procedure, using an I125 labeled Vitamin D 1, 25-Dihydroxy analog. None of the SPE extractors on the market met all of our laboratories requirements of small foot print, organic solvent compatibility, multiple solvent capability, 1 mL column compatibility, 96-sample through-put, SBS format compatibility, positive pressure displacement, and dry down. An automated SPE extractor was developed in house. The extractor was developed around KD Scientific’s UltraSpense 2000 reagent dual plate dispenser. The UltraSpense has a small footprint and can pipette organic solvents with high accuracy into SBS formatted consumables. Multiple reagents were accessed with the addition of a 6 channel selector valve. The dispenser has positions for two plates, one in front of the other. Above each position a 96-port manifold was placed for positive displacement of the reagents through the columns. The back position was designed to handle vacuum removal of the wash waste. The front position was designed for sample elution and drying, with a heated base and retractable heated needle dryer. Software programming for walk away extraction was done in Lab View. Total time for the processing of 96 samples for column activation, 3 washes, elution and dry down was approximately 40 minutes. The automated extractor was evaluated against the manual method for validation. Studies for precision, accuracy, linearity, sensitivity and carry-over were performed and results reported. Five sample pools were created for precision determination, spanning the range of 17 to 90 pg/mL. Within run CV’s varied from 8.2% at 17 pg/mL to 10.5% at 90 pg/mL. Higher CV’s were observed at higher concentrations due to the inverse relationship between counts and concentration in the RIA procedure. Correlation between values obtained through the manual and automated were good (y = 0.928x + 1.876, r 2 =0.893). Better correlation was seen with samples prepared for LC-MS/MS (y = 1.19x + 0.841, r 2 = 0.95). The assay was found to be linear over the standard range of 6 to 274 pg/mL with the lowest level of detection at 6 pg/mL. No evidence of cross contamination was observed when samples were extracted in a “checker board” layout with samples in excess of 250 pg/mL. Based on these results, the extractor has been placed into the production lab for daily use. We conclude that this design for automated solid phase extraction may be of greater benefit for a clinical laboratory then those currently available.
Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New Target for Antiretroviral Therapy (2001)

ABSTRACT Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-α) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-α then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-α via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
Novel adhesive development for CMOS-compatible thin wafer handling (2010)

3D integration is a promising technology for advancing the performance of semiconductors since it can provide higher density, faster speed and better power efficiency in a smaller form factor. The Through Silicon Via (TSV) is an important component for achieving the benefits of 3D integrated semiconductors. However, depending on the temporary wafer bonding technology's behavior during processing at temperatures above 250°C, the TSV formation process can be limited. Process integration steps where high temperature tolerance is critical include PECVD, PVD, and solder reflow. In the case of PECVD, the difficulty and challenge is to obtain sufficient thin film insulator performance at low process temperatures because the quality of plasma-deposited insulating films is known to degrade as processing temperatures are reduced. Furthermore, stress builds up in the thinned wafer due to CTE difference in the various layers of films on the chips and the adhesive/carrier system must be able to control any movement induced by this stress. The thin wafer handling system from TOK called Zero Newton was used in this study. The Zero Newton system provides low stress bonding and debonding capabilities by utilizing perforated glass carriers with solvent dissolvable adhesives. By specially engineering the adhesives for use over higher temperature ranges, it is possible to deposit good quality insulating PECVD films and still debond the wafer from the temporary carrier without stress and without adhesive residue. The focus of this paper is to report on the development of a novel temporary adhesive with a temperature tolerance of up to 280°C for use during PECVD processing. Temporary adhesives can be made from various polymers but the thermal stability is a very important consideration in the selection process. Factors such as out-gassing and cross-linking affect the ultimate thermal budget of integration processing as well as the speed of dissolution during the debonding process. Two other important parameters that need to be considered include the glass transition point (Tg) of the adhesive, and a parameter we call the “softening point”. We have found that the softening point needs to be sufficiently high in order to process CMOS-compatible wafers at high temperatures. Thinned wafers fabricated with TSVs and Cu damascene wiring layers can give rise to significant stress during processing. This stress can manifest itself as non-planarity or warpage in the wafer and in individual die. Thus, a temporary adhesive must not only provide bonding between a mechanical handler and the thinned wafer but also must constrain micro and macro level warpage in the wafer during processing.
Transcriptional profiling of cecal gene expression in probiotic- and Salmonella- challenged neonatal chicks (2011)

Probiotics are currently used to improve health and reduce enteric pathogens in poultry. However, the mechanisms by which they reduce or prevent disease are not known. Salmonella are intracellular pathogens that cause acute gastroenteritis in humans, and infections by nontyphoid species of Salmonella also can result in diarrhea, dehydration, and depression in poultry. Frequently, however, no clinical signs of infection are apparent in poultry flocks. In this study, day-of-hatch chicks were challenged with Salmonella enterica serovar Enteritidis (SE) and treated 1 h later with a poultry-derived, Lactobacillus-based probiotic culture (FloraMax-B11, Pacific Vet Group USA Inc., Fayetteville, AR). Cecae were collected 12 and 24 h posttreatment for Salmonella detection and RNA isolation for microarray analysis of gene expression. At both 12 and 24 h, SE was significantly reduced in chicks treated with the probiotic as compared with the birds challenged with only SE (P < 0.05). Microarray analysis revealed gene expression differences among all treatment groups. At 12 h, 170 genes were expressed at significantly different levels (P < 0.05), with a minimum difference in expression of 1.2-fold. At 24 h, the number of differentially regulated genes with a minimum 1.2-fold change was 201. Pathway analysis revealed that at both time points, genes associated with the nuclear factor kappa B complex, as well as genes involved in apoptosis, were significantly regulated. Based on this analysis, probiotic-induced differential regulation of the genes growth arrest-specific 2 (GAS2) and cysteine-rich, angiogenic inducer, 61 (CYR61) may result in increased apoptosis in the cecae of chicks. Because Salmonella is an intracellular pathogen, we suggest that increased apoptosis may be a mechanism by which the probiotic culture reduces Salmonella infection.
Fall-curve (2018)

The proliferation of Internet of Things (IoT) devices has led to the deployment of various types of sensors in the homes, offices, buildings, lawns, cities, and even in agricultural farms. Since IoT applications rely on the fidelity of data reported by the sensors, it is important to detect a faulty sensor and isolate the cause of the fault. Existing fault detection techniques demand sensor domain knowledge along with the contextual information and historical data from similar near-by sensors. However, detecting a sensor fault by analyzing just the sensor data is non-trivial since a faulty sensor reading could mimic non-faulty sensor data. This paper presents a novel primitive, which we call the Fall-curve - a sensor's voltage response when the power is turned off - that can be used to characterize sensor faults. The Fall-curve constitutes a unique signature independent of the phenomenon being monitored which can be used to identify the sensor and determine whether the sensor is correctly operating.