gebhart/patrepeval huggingface dataset:
Free space optical communication a new industry and a new challenge in defining laser safety in the public sector (2001)

This article discusses the application and implications of a new class of optical wireless broadband communications technology utilizing line-of-sight optical links commonly referred to as free space optical communications (FSOC). As the emergence of this technology is likely to spawn an industry with rapid growth in the broadband access telecommunications market, the article will also briefly examine some of the technologies unique operational considerations and focus on the public safety issues associated with large-scale public deployment, and will conclude with a brief review of future directions and recent and very preliminary committee drafts on the operational and safety standards being proposed by members of ANSI Z136.6 and IEC TC76 working group 5-part 12. Comprehensive standards for FSOC applications are not expected before 2003.
Ultrafast Carrier Dynamics and Bandgap Renormalization in Layered PtSe2 (2019)

Carrier interactions in 2D nanostructures are of central importance not only in condensed-matter physics but also for a wide range of optoelectronic and photonic applications. Here, new insights into the behavior of photoinduced carriers in layered platinum diselenide (PtSe<sub>2</sub> ) through ultrafast time-resolved pump-probe and nonlinear optical measurements are presented. The measurements reveal the temporal evolution of carrier relaxation, chemical potential and bandgap renormalization in PtSe<sub>2</sub> . These results imply that few-layer PtSe<sub>2</sub> has a semiconductor-like carrier relaxation instead of a metal-like one. The relaxation follows a triple-exponential decay process and exhibits thickness-dependent relaxation times. This occurs along with a band-filling effect, which can be controlled based on the number of layers and may be applied in saturable absorption for generating ultrafast laser pulses. The findings may provide means to study many-body physics in 2D materials as well as potentially leading to applications in the field of optoelectronics and ultrafast photonics.
Orientation Parameter (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Disarrangement of the distal radioulnar joint (1993)

Log in or Register Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Register Login HomeCurrent IssuePrevious Issues Current Orthopaedic PracticeCurrent Opinion in Orthopaedics (1999-2007)Clinical Orthopaedics and Related Research (1976-2007) Published Ahead-of-PrintCOP eNewsMy CollectionsJournal Info About the JournalEditorial BoardInformation for AuthorsAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Strand-level proximity losses in PM machines designed for high-speed operation (2008)

The stator windings of surface PM synchronous machines with fractional-slot concentrated windings are vulnerable to high proximity losses when operated at high speeds due to their typically high pole numbers and resulting high electrical frequencies. The limitations of an existing 1-D flux density model are demonstrated and an improved 2-D analytical model is introduced for estimating flux densities and stand-level proximity losses inside the slots. The 2-D analytical model is shown to provide good matches with finite element analysis for the predicted flux densities and proximity losses inside a rectangular slot with a variable slot opening and electrical frequency.
CD19‐CAR engineered NK‐92 cells are sufficient to overcome NK cell resistance in B‐cell malignancies (2016)

Many B-cell acute and chronic leukaemias tend to be resistant to killing by natural killer (NK) cells. The introduction of chimeric antigen receptors (CAR) into T cells or NK cells could potentially overcome this resistance. Here, we extend our previous observations on the resistance of malignant lymphoblasts to NK-92 cells, a continuously growing NK cell line, showing that anti-CD19-CAR (αCD19-CAR) engineered NK-92 cells can regain significant cytotoxicity against CD19 positive leukaemic cell lines and primary leukaemia cells that are resistant to cytolytic activity of parental NK-92 cells. The 'first generation' CAR was generated from a scFv (CD19) antibody fragment, coupled to a flexible hinge region, the CD3ζ chain and a Myc-tag and cloned into a retrovirus backbone. No difference in cytotoxic activity of NK-92 and transduced αCD19-CAR NK-92 cells towards CD19 negative targets was found. However, αCD19-CAR NK-92 cells specifically and efficiently lysed CD19 expressing B-precursor leukaemia cell lines as well as lymphoblasts from leukaemia patients. Since NK-92 cells can be easily expanded to clinical grade numbers under current Good Manufactoring Practice (cGMP) conditions and its safety has been documented in several phase I clinical studies, treatment with CAR modified NK-92 should be considered a treatment option for patients with lymphoid malignancies.
GaN-based superluminescent diodes with long lifetime (2016)

We report on the reliability of GaN-based super-luminescent light emitting diodes (SLEDs) emitting at a wavelength of 405 nm. We show that the Mg doping level in the p-type layers has an impact on both the device electro-optical characteristics and their reliability. Optimized doping levels allow decreasing the operating voltage on single-mode devices from more than 6 V to less than 5 V for an injection current of 100 mA. Furthermore, maximum output powers as high as 350 mW (for an injection current of 500 mA) have been achieved in continuous-wave operation (CW) at room temperature. Modules with standard and optimized p-type layers were finally tested in terms of lifetime, at a constant output power of 10 mW, in CW operation and at a case temperature of 25 &deg;C. The modules with non-optimized p-type doping showed a fast and remarkable increase in the drive current during the first hundreds of hours together with an increase of the device series resistance. No degradation of the electrical characteristics was observed over 2000 h on devices with optimized p-type layers. The estimated lifetime for those devices was longer than 5000 h.
Optical Design of the PI-Test MEBT Beam Scraping System (2017)

PI-Test [1] is an accelerator facility under construction at Fermilab that will provide a platform to demonstrate critical technologies and concept of front-end of the PIP-II superconducting radio frequency (SRF) linac. It will be capable to accelerate an H⁻ ion beam with average current of 2 mA up to 25 MeV in continuous wave (CW) regime. To protect the SRF components from beam irradiation, the Medium Energy Beam Transport (MEBT) section of PI-Test includes an elaborated beam scraping system. It consists of four assemblies spread along the MEBT, with each assembly composed of four radiation-cooled, electrically isolated plates that can be moved into the beam in horizontal and vertical direction. The primary objectives of scraping system are to intercept particles with large transverse action and to protect the beamline elements and SRF linac in case of errors with beam focusing or steering. In this paper we formulate requirements for the scraping system and discuss factors affecting its efficiency. An optical design compatible with PI-Test MEBT is also presented.
"The Blood That Runs Through the Veins": The Creation of Identity and a Client's Experience of Cuban-American "Santeria Dilogun" Divination (1993)

Michael Atwood Mason, "The Blood That Runs Through the Veins": The Creation of Identity and a Client's Experience of Cuban-American "Santería Dilogún" Divination, TDR (1988-), Vol. 37, No. 2 (Summer, 1993), pp. 119-130
Comments on Marchand et al., PAIN , 45 (1991) 249–257 (1992)

Pain: April 1992 - Volume 49 - Issue 1 - p 156-157 doi: 10.1016/0304-3959(92)90206-Q
Differential expression of protein kinase C isozymes in rat cerebellum. (1990)

Protein kinase C (PKC) is a family of enzymes found throughout the body, with the greatest diversity and concentration in brain tissue. To understand further the differential role of PKC isozymes in brain, we have raised antibodies against four PKC isoforms--alpha, beta I, beta II and gamma--using specific amino acid sequences predicted from cDNA sequences. On Western blot of rat cerebellar homogenate, these antibodies stained a band of Mr 80,000, a known molecular mass for PKC, except for anti-PKC(beta II), which stained an additional minor Mr 90,000 band. On rat cerebellar sections, specific sets of cells were stained by each antibody. In the molecular layer, stellate and basket cells were stained with anti-PKC(alpha) but not with anti-PKC(beta I), -(beta II), or -(gamma). Anti-PKC (alpha) and anti-PKC(beta II) seemed to stain the Bergmann glial fibre. In the Purkinje cell layer, Purkinje cells were stained with anti-PKC[beta I) and -(gamma). Anti-PKC (alpha) and -(beta II) were negative. Interestingly, a few Purkinje cells were not stained with anti-PKC(gamma). In the granule cell layer, both granule and Golgi cells were stained with anti-PKC(beta I) and -(beta II) but not with anti-PKC(alpha) or -(gamma). Glial cells were stained with anti-PKC(beta II) but not with anti-PKC(alpha), -(beta I), or -(gamma). This study suggests a differential distribution of PKC isoforms in different cells, irrespective of their neurotransmitters. The presence of both positive and negative staining of Purkinje cells with anti-PKC(gamma) raised the possibility of their heterogeneity.
A New Data Modulation Method for Multi-Level Optical Recording (2003)

Previously, we developed a data detection method named data detection using pattern recognition (DDPR) for multi-level data recording on optical discs. We have added a new data modulation process, least significant bit (LSB) limited modulation (LLM), to DDPR in order to reduce data errors. The LLM modulates 11-bit input data into four eight-level data symbols (3 bits×4 data=12 bits). The experimental results showed that coupling LLM with DDPR was effective to reduce data errors.
Homeotropic nano-particle assembly on degenerate planar nematic interfaces: films and droplets (2015)

A continuum theory is used to study the effects of homeotropic nano-particles on degenerate planar liquid crystal interfaces. Particle self-assembly mechanisms are obtained from careful examination of particle configurations on a planar film and on a spherical droplet. The free energy functional that describes the system is minimized according to Ginzburg-Landau and stochastic relaxations. The interplay between elastic and surface distortions and the desire to minimize defect volumes (boojums and half-Saturn rings) is shown to be responsible for the formation of intriguing ordered structures. As a general trend, the particles prefer to localize at defects to minimize the overall free energy. However, multiple metastable configurations corresponding to local minima can be easily observed due to the high energy barriers that separate distinct particle arrangements. We also show that by controlling anchoring strength and temperature one can direct liquid-crystal mediated nanoparticle self-assembly along well defined pathways.
Photochemical Cyclobutanone Expansions (1987)

As a model for a new approach to bond formation at anomeric carbons, the addition of various heteroatom derivatives to oxacarbenes generated by the photochemical ring expansion of cyclobutanones has been examined.Practical procedures have been developed for the insertion of such carbenes into heteroatom-H bonds from alcohols, thiols, and mines
Large-scale live active learning: Training object detectors with crawled data and crowds (2011)

Active learning and crowdsourcing are promising ways to efficiently build up training sets for object recognition, but thus far techniques are tested in artificially controlled settings. Typically the vision researcher has already determined the dataset's scope, the labels “actively” obtained are in fact already known, and/or the crowd-sourced collection process is iteratively fine-tuned. We present an approach for live learning of object detectors, in which the system autonomously refines its models by actively requesting crowd-sourced annotations on images crawled from the Web. To address the technical issues such a large-scale system entails, we introduce a novel part-based detector amenable to linear classifiers, and show how to identify its most uncertain instances in sub-linear time with a hashing-based solution. We demonstrate the approach with experiments of unprecedented scale and autonomy, and show it successfully improves the state-of-the-art for the most challenging objects in the PASCAL benchmark. In addition, we show our detector competes well with popular nonlinear classifiers that are much more expensive to train.
Smooth Muscle and Other Cell Sources for Human Blood Vessel Engineering (2011)

Despite substantial progress in the field of vascular tissue engineering over the past decades, transition to human models has been rather challenging. The limited replicative life spans of human adult vascular cells, and their slow rate of collagenous matrix production in vitro, have posed important hurdles in the development of mechanically robust and biologically functional engineered grafts. With the more recent advances in the field of stem cells, investigators now have access to a plethora of new cell source alternatives for vascular engineering. In this paper, we review various alternative cell sources made available more recently for blood vessel engineering and also present some recent data on the derivation of smooth muscle cells from human induced pluripotent stem cells.
Performance characteristics of the VIDAS ® SARS-COV-2 IgM and IgG serological assays (2020)

ABSTRACT The COVID-19 pandemic, caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread worldwide. Serological testing for SARS-CoV-2-specific antibodies plays an important role in understanding and controlling the pandemics, notably through epidemiological surveillance. Well validated and highly specific SARS-CoV-2 serological assays are urgently needed. We describe here the analytical and clinical performance of VIDAS ® SARS-CoV-2 IgM and VIDAS ® SARS-CoV-2 IgG, two CE-marked, EUA-authorized, automated, qualitative assays for the detection of SARS-CoV-2-specific IgM and IgG, respectively. Both assays showed high within-run and within-laboratory precision (coefficients of variation &lt; 11.0%) and very low cross-reactivity towards sera of patients with a past common coronavirus or respiratory virus infection. Clinical specificity determined on up to 989 pre-pandemic healthy donors was ≥ 99% with a narrow 95% confidence interval for both IgM and IgG assays. Clinical sensitivity was determined on up to 232 samples from 130 RT-PCR-confirmed SARS-CoV-2 patients. The positive percent agreement (PPA) with SARS-CoV-2 PCR reached 100% at ≥ 16 days (VIDAS ® SARS-CoV-2 IgM) and ≥ 32 days (VIDAS ® SARS-CoV-2 IgG) of symptom onset. Combined IgM/IgG test results improved the PPA compared to each test alone. SARS-CoV-2 IgG seroconversion followed closely that of SARS-CoV-2 IgM and remained stable over time, while SARS-CoV-2 IgM levels rapidly declined. Interestingly, SARS-CoV-2-specific IgM and IgG responses were significantly higher in COVID-19 hospitalized vs. non-hospitalized patients. Altogether, the VIDAS ® SARS-CoV-2 IgM and IgG assays are highly specific and sensitive serological tests suitable for the reliable monitoring of past SARS-CoV-2 infections and for seroepidemiology investigations.
Emergent anisotropy in magnetic metamaterials (2022)

We demonstrate directional dependence of the self-modification of internal mesospin textures in magnetic metamaterials, arising from the coupling of the atomic- and mesoscopic length-scales. Dressing the mesospins in different directions enables the quantification of the degree of texture in the internal magnetization and its impact on the interaction energy of the mesospins. The emerging anisotropy is manifested in a directional dependence of the remanent magnetization with temperature.
Technologies for SOA-based distributed large scale process monitoring and control systems (2012)

In a SOA-based system the applications are organized in a manner such that interoperable services can be used from different domains. In a process industry context, different domains can refer to, for example, process instrumentation and monitoring, execution of process control, data acquisition, etc. Large process industry systems are a complex and potentially very large sets of multi-disciplinary, heterogeneous, networked distributed systems. Current industrial process control systems are typically vendor specific; in addition the different domains are associated with different layers, different standards and different technologies. In the paper the authors report about the investigations and assessments performed to find answers for four major critical questions that arise as key when technologies have to be selected and used in a true Service Oriented Architecture (SOA) based distributed large scale Process Monitoring and Control system: (1) Real-time SOA (what are the limits of bringing SOA into high performance control loops?); (2) Management of large scale industrial distributed control systems (is it feasible to manage up to tens of thousands of service-oriented devices?); (3) Distributed event-based systems are asynchronous (what are the limits compared to traditional periodic scanning systems?) and (4) Service specification (which semantics are the most suitable for specifying process control and monitoring services?).
Human Leukocyte Antigen-DQ8 Transgenic Mice: a Model To Examine the Toxicity of Aerosolized Staphylococcal Enterotoxin B (2005)

Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts of cytokines by binding to major histocompatibility complex (MHC) class II and cross-linking susceptible T-cell receptors. Efforts to develop effective therapeutic strategies to protect against SEs delivered as an aerosol have been hampered by the lack of small animal models that consistently emulate human responses to these toxins. Here, we report that human leukocyte antigen-DQ8 (HLA-DQ8) transgenic (Tg) mice, but not littermate controls, succumbed to lethal shock induced by SEB aerosols without potentiation. Substantial amounts of perivascular edema and inflammatory infiltrates were noted in the lungs of Tg mice, similar to the pathology observed in nonhuman primates exposed by aerosol to SEB. Furthermore, the observed pathologies and lethal shock correlated with an upsurge in proinflammatory cytokine mRNA gene expression in the lungs and spleens, as well as with marked increases in the levels of proinflammatory circulating cytokines in the Tg mice. Unlike the case for littermate controls, telemetric evaluation showed significant hypothermia in Tg mice exposed to lethal doses of SEB. Taken together, these results show that this murine model will allow for the examination of therapeutics and vaccines developed specifically against SEB aerosol exposure and possibly other bacterial superantigens in the context of human MHC class II receptors.
124 Investigating the Impact of Ambient Lighting on Adenoma Detection Rate and Eye Fatigue During Screening Colonoscopy (2019)

INTRODUCTION: Previous studies indicate that adenoma detection rate (ADR) decreases as the number of consecutive hours performing procedures increases. Differences in adaptation between a bright screen and a dimly lit room may contribute to eye strain and eye strain related symptoms occur in most video display users. Increasing ambient light may improve symptoms of eye strain, but ambient light effects have yet to be explored in the field of gastroenterology. We aim to determine if the use of ambient lighting, between 75–150 lux, during screening colonoscopy will maintain ADRs and decrease symptoms of eye strain. METHODS: A single center study comparing screening colonoscopies in a dimly lit room to use of ambient lighting by 9 gastroenterologists was performed. Retrospective data was collected over a 6-month period performed in procedure rooms with no lighting. Prospective data was then collected on colonoscopies with ambient lighting during the same 6 calendar months the following year. A survey on eye fatigue was completed by all gastroenterologists before and after the use of ambient lighting. Satisfaction surveys were completed by gastroenterologists, anesthesiologists, nurses and technicians. RESULTS: There were 498 low light and 611 ambient light cases. 172 adenomas (ADR = 34.5%) were detected with low light and 220 adenomas were detected with ambient light (ADR = 36.0%) ( P = 0.611). For low light cases, ADR was 37.5% for 1st cases of the day and 31.9% for last cases of the day ( P = 0.545) (Table 1). For ambient light cases, the ADR was 34.1% for 1st cases of the day and 36.9% for last cases of the day ( P = 0.266). Overall difference in ADR between 1st and last cases using ambient lighting (+2.80%) versus no lighting (−5.60%), was statistically significant ( P = 0.010) (Table 2). 41% of respondents agreed or strongly agreed fewer symptoms of eyes strain occurred with ambient light and 54% of respondents felt that ambient light improved detection of changes in patient status. CONCLUSION: Our data suggests that performing screening colonoscopies with ambient light may improve the differential change in ADR that occurs from the beginning to the end of the day, as compared with lights off. This improvement in ADR may be related to improved symptoms of eye strain, and further investigation is warranted.
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host–Pathogen Interactions and Innate Immunity (2019)

The small GTase Arf6 has several important functions in intracellular vesicular trafficking and regulates the recycling of different types of cargo internalized via clathrin-dependent or -independent endocytosis. It activates the lipid modifying enzymes PIP 5-kinase and phospholipase D, promotes actin polymerization, and affects several functionally distinct processes in the cell. Arf6 is used for the phagocytosis of pathogens and can be directly or indirectly targeted by various pathogens to block phagocytosis or induce the uptake of intracellular pathogens. Arf6 is also used in the signaling of Toll-like receptors and in the activation of NADPH oxidases. In this review, we first give an overview of the different roles and mechanisms of action of Arf6 and then focus on its role in innate immunity and host-pathogen interactions.
ChemInform Abstract: Oxidation of Alcohols by Perfluoro‐cis‐2,3‐dialkyloxaziridines. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.