gebhart/patrepeval huggingface dataset:
Interdisciplinary Research at the Nation's Coastal Laboratories (1996)

The nation's coastal (i.e., marine and Great Lakes) laboratories and programs of aquatic research face serious challenges for survival in the decades to come. Although research in these institutions is strongly interdisciplinary, this characteristic and its effect are not widely recognized. Examples of successful interdisciplinary research are many, encompassing a wide range of scales of operation, from the varied technical approaches taken in individual laboratories to multi-laboratory, multi-institutional and multi-platform programs of very large scale. Our survey of interdisciplinary research in the nation's marine and coastal laboratories leads to three conclusions: (1) The trend toward collaboration in marine research is scientist-driven, rapid, and inexorable. It is driven by problems of increasing complexity, and the recognition that multiple approaches are synergistic and powerful, producing answers where single approaches cannot. (2) This trend is rapidly increasing the diversity of expertise and technical competence among coastal laboratories. (3) And the research community and its support agencies must therefore find new ways of representing this rapidly increasing diversity within the country's marine laboratories and their programs. Given past successes, we may be tempted to push forward with large multidisciplinary programs, but we should not neglect the funding required by innovative individual scientists. The marine and aquatic research community and its funding agencies face a major challenge in the years ahead: they must develop a publicly recognizable, national agenda for marine and coastal research that adequately represents the broad spectrum of interdisciplinary research entailed, while ensuring that nonconventional work and innovative "individual" science be effectively funded. Such a balanced approach is most likely to effect a sustained economic development of the nation's coastal zone.
Designing Developable Mechanisms From Flat Patterns (2020)

Abstract This paper presents tools and methods to design cylindrical and conical developable mechanisms from flat, planar patterns. Equations are presented that relate the link lengths and link angles of planar and spherical mechanisms to the dimensions in a flat configuration. These flat patterns can then be formed into curved, developable mechanisms. Guidelines are established to determine if a mechanism described by a flat pattern can exhibit intramobile or extramobile behavior. A developable mechanism can only potentially exhibit intramobile or extramobile behavior if none of the links extend beyond half of the flat pattern. The behavior of a mechanism can change depending on the location of the cut of the flat pattern. Different joint designs are discussed including lamina emergent torsional (LET) joints. Physical examples are presented.
Correlation and spectrum of Doppler signal zero crossings using a photon correlation computer (1988)

A method is described to extend the usefulness of photon correlation computers beyond the low photon density regime and through the photon pile-up regime, thereby permitting application to signals that are strong by the standards of photon correlation, but noisy by the standards of conventional Doppler signal processors. The technique correlates the pulse train obtained from the zero crossings of the analogue signal formed by filtering the photon-resolved signal. The correlation and its spectrum contain strong peaks that define the Doppler signal frequency.
Scintillation and dosimetric properties of LiF/CaF 2 :Dy eutectic composite (2021)

Abstract Scintillation and dosimetric properties of a LiF/CaF 2 :Dy eutectic composite have been studied. In the X-ray induced emission spectrum and decay curve, we observed luminescence due to self-trapped exciton of CaF 2 and 4f–4f transitions of Dy 3+ ions. The LiF/CaF 2 :Dy eutectic composite showed the light yield of 3000 photons/neutron as a neutron scintillator. The LiF/CaF 2 :Dy eutectic composite showed the measurable range from 1 mGy to 10 Gy as a thermoluminescence dosimetric material. The LiF/CaF 2 :Dy eutectic composite can act as a dual functional material for neutron detection and X-ray dosimetry.
Identification of a novel, small molecule inhibitor of KCNQ2 channels (2013)

A high-throughput screen (HTS) of the Molecular Libraries Probe Centers Network (MLPCN) library was performed using a thallium influx assay in order to identify inhibitors of potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2) channels. Structure activity relationship (SAR) studies of active compounds yielded ML252, a potent (IC50 = 69 nM) inhibitor of KCNQ2 channels in electrophysiological assays. ML252 displayed more than forty-fold selectivity for blocking KCNQ2 channels compared with KCNQ1 channels. SAR studies revealed a site on ML252 at which small structural changes caused a functional shift from antagonist to agonist activity, suggesting that ML252 interacted with a critical site for controlling gating of KCNQ2 channels. ML252 represents a novel and potent inhibitor of KCNQ2 channels with a selectivity profile that enables use of the probe for investigating the role of KCNQ2 channels in neuronal function.
Imagent Improves Endocardial Border Delineation, Inter‐reader Agreement, and the Accuracy of Segmental Wall Motion Assessment (2003)

Use of Imagent during echocardiographic imaging improves EBD, providing a significant improvement in inter-reader agreement in SWM evaluation with echo and greater than a threefold improvement in SWM scoring accuracy with MRI.
A Dictyostelium myosin II lacking a proximal 58-kDa portion of the tail is functional in vitro and in vivo. (1992)

We used molecular genetic approaches to delete 521 amino acid residues from the proximal portion of the Dictyostelium myosin II tail. The deletion encompasses approximately 40% of the tail, including the S2-LMM junction, a region that in muscle myosin II has been proposed to be important for contraction. The functions of the mutant myosin II are indistinguishable from the wild-type myosin II in our in vitro assays. It binds to actin in a typical rigor configuration in the absence of ATP and it forms filaments in a normal salt-dependent manner. In an in vitro motility assay, both monomeric and filamentous forms of the mutant myosin II translocate actin filaments at 2.4 microns/s at 30 degrees C, similar to that of wild-type myosin II. The mutant myosin II is also functional in vivo. Cells expressing the mutant myosin II in place of the native myosin II perform myosin II-dependent activities such as cytokinesis and formation of fruiting bodies, albeit inefficiently. Growth of the mutant cells in suspension gives rise to many large multinucleated cells, demonstrating that cytokinesis often fails. The majority of the fruiting bodies are also morphologically abnormal. These results demonstrate that this region of the myosin II tail is not required for motile activities but its presence is necessary for optimum function in vivo.
Estimation of Condensate Inside Dryer Cylinders During Section Shutdown (2013)

The presence of condensate inside the dryer cylinders produces a significant increase in the power requirements during starting, putting at risk the capacity of the drive to complete a successful start. In past papers, authors developed estimation algorithms for the detection of condensate during section starting. This paper proposes and evaluates a new strategy that will complement the previous algorithms. This strategy will detect the presence of condensate from the condensate collapsing during the section shutdown. The proposed correlations are derived through a complete experimental evaluation in two experimental cylinders covering rim thicknesses up to 55 mm. The estimation algorithms are split into a low-/moderate-condensate-load zone and a high-condensate-load zone. Results confirm the robustness and accuracy of the proposed algorithms.
Low Complexity Algorithms for Multi-Cell Joint Channel Estimation in TDD-CDMA Systems (2011)

In this letter, we propose two low complexity algorithms for least square (LS) and minimum mean square error (MMSE) based multi-cell joint channel estimation (MJCE). The algorithm for LS-MJCE achieves the same complexity and mean square error (MSE) performance as the previously proposed most efficient algorithm, while the algorithm for MMSE-MJCE is superior to the conventional ones, in terms of either complexity or MSE performance.
Photonic Crystal Slot Waveguide Spectroscopy for the Detection of Chemical Warfare Simulants (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Chakravarty and R. T. Chen, "Photonic Crystal Slot Waveguide Spectroscopy for the Detection of Chemical Warfare Simulants," in CLEO:2011 - Laser Applications to Photonic Applications, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper CThC4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Automated test case generation for an autopilot requirement prototype (2011)

Designing safety-critical automation with robust human interaction is a difficult task that is susceptible to a number of known Human-Automation Interaction (HAI) vulnerabilities. It is therefore essential to develop automated tools that provide support both in the design and rapid evaluation of such automation. The Automation Design and Evaluation Prototyping Toolset (ADEPT) enables the rapid development of an executable specification for automation behavior and user interaction. ADEPT supports a number of analysis capabilities, thus enabling the detection of HAI vulnerabilities early in the design process, when modifications are less costly. In this paper, we advocate the introduction of a new capability to model-based prototyping tools such as ADEPT. The new capability is based on symbolic execution that allows us to automatically generate quality test suites based on the system design. Symbolic execution is used to generate both user input and test oracles; user input drives the testing of the system implementation, and test oracles ensure that the system behaves as designed. We present early results in the context of a component in the Autopilot system modeled in ADEPT, and discuss the challenges of test case generation in the HAI domain.
On the Use of Independent Component Analysis to Denoise Side-Channel Measurements. (2018)

Independent Component Analysis (ICA) is a powerful technique for blind source separation. It has been successfully applied to signal processing problems, such as feature extraction and noise reduction, in many different areas including medical signal processing and telecommunication. In this work, we propose a framework to apply ICA to denoise side-channel measurements and hence to reduce the complexity of key recovery attacks. Based on several case studies, we afterwards demonstrate the overwhelming advantages of ICA with respect to the commonly used preprocessing techniques such as the singular spectrum analysis. Mainly, we target a software masked implementation of an AES and a hardware unprotected one. Our results show a significant Signal-to-Noise Ratio (SNR) gain which translates into a gain in the number of traces needed for a successful side-channel attack. This states the ICA as an important new tool for the security assessment of cryptographic implementations.
Are macular drusen in midlife a marker of accelerated biological ageing? (2021)

In this representative general population sample, macular drusen in midlife were not associated with accelerated ageing. Future studies tracking longitudinal changes in drusen number and severity at older ages may reveal whether drusen are a biomarker of accelerated ageing.
Highly potent cytotoxic compounds with inhibitory effects on tubulin polymerization and topoisomerase II (2007)

C218 AEZS-112 (ZEN-012) is a novel multi-targeted cytotoxic compound with inhibitory effects on tubulin polymerization, topoisomerase II and angiogenesis. This drug has demonstrated in vivo activity after oral administration in various tumor models including mammary, colon, skin and leukemic cancers and has recently entered phase I clinical trials. Here we present results of the pharmacological characterization of three novel AEZS-112 follow-up candidates.  All three compounds posess highly potent anti-proliferative activity in a diverse panel of about 30 cancer cell lines with IC50 values in the range of 30 to 160 nM. Mode-of-action studies revealed that all compounds inhibit tubulin polymerization comparable to AEZS-112 (IC50 = 1.49 µM) and are potent inhibitors of topoisomerase II. Compound 2 even exceeds the activity of the reference compound amsacrine in a decatenation assay.  It could be shown that all compounds are able to arrest KB/HeLa cells in G2/M phase at nanomolar concentrations and induce apoptosis in U937 cells as proven by caspase activity, DNA fragmentation and annexin V staining. The potency ranking of the follow-up candidates in these assays is in accordance with the cytotoxic potential of the compounds. Compound 3 shows the highest potency of 13 to 16 nM EC50.  In vitro liver microsomal and plasma stability of the potential follow-up candidates are comparable to AEZS-112 or even improved, thus demonstrating suitability for in vivo efficacy studies. In order to prepare for such studies, the impact of AEZS-112 and compound 1 on the clonogenic growth of 24 human tumor xenografts covering different classes of tumors has been analyzed. Overall, doubling of potency by compound 1 could be demonstrated. Moreover, this study allows to discriminate between more and less sensitive tumor types, hence supporting the selection of the most appropriate tumor models.  Based on their interesting pharmacological profiles all three candidates will be subjected to human tumor xenograft in vivo models before selecting an AEZS-112 follow-up candidate for preclinical development.
Hepatic Differentiation Potential of Commercially Available Human Mesenchymal Stem Cells (2006)

The ready availability and low immunogenicity of commercially available mesenchymal stem cells (MSC) render them a potential cell source for the development of therapeutic products. With cell source a major bottleneck in hepatic tissue engineering, we investigated whether commercially available human MSC (hMSC) can transdifferentiate into the hepatic lineage. Based on previous studies that find rapid gain of hepatic genes in bone marrow-derived stem cells cocultured with liver tissue, we used a similar approach to drive hepatic differentiation by coculturing the hMSC with rat livers treated or untreated with gadolinium chloride (GdCl(3)). After a 24-hour coculture period with liver tissue injured by GdCl(3) in a Transwell configuration, approximately 34% of the cells differentiated into albumin-expressing cells. Cocultured cells were subsequently maintained with growth factors to complete the hepatic differentiation. Cocultured cells expressed more hepatic gene markers, and had higher metabolic functions and P450 activity than cells that were only differentiated with growth factors. In conclusion, commercially available hMSC do show hepatic differentiation potential, and a liver microenvironment in culture can provide potent cues to accelerate and deepen the differentiation. The ability to generate hepatocyte-like cells from a commercially available cell source would find interesting applications in liver tissue engineering.
Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial (2018)

Moderate to severe skin rash after zalutumumab during radiation treatment was associated with improved OS, independent of HPV/p16-status. Genetic variants in AREG (member of the EGF family) may be associated with increased risk of skin rash.
Predictive adaptive loading for HIPERLAN II (2002)

Adaptive loading is able to significantly reduce the average symbol error rate (SER) of OFDM-based wireless local networks by exploiting the channel frequency diversity. In time-varying channels however these gains disappear quickly when the channel state feedback rate is limited. We show that by combining ML channel estimation with robust MMSE prediction filters, we can predict the optimal constellation sizes and regain most of the achievable gain of adaptive loading. With only 4 channel measurements spaced one MAC frame apart, the loss compared to the performance of adaptive loading with perfect channel knowledge is limited to 0.7 dB and a gain of 10 dB is achieved over non-adaptive OFDM for an SER=10/sup -6/.
Power control method in PWR type reactors (1987)

Purpose: To improve the adaptable property of operation patterns capable of power change to an assumed low power state and rapid power change to optional power states with no undesired effects to the power distribution. Method: Power conditioning control rod groups having neutron absorbing performance which is set lower in the lower portion and greater in the upper portion are divided into a plurality of subgroups. Upon power change, power control rods of the plurality of subgroups are successively displaced between the fuel withdrawal position and full insertion position. Accordingly, even in a case if power changes in the course of the designed low power state, only the first subgroup can, for example, be inserted fully, by which distortion in the vertical power distribution in the intermediate power state can be overcome. (Horiuchi, T.).
An Assessment of a Rapid SARS-CoV-2 Antigen Test in Bangladesh (2022)

Early detection of SARS-CoV-2 infection is crucial to prevent its spread. This study aimed to document test sensitivity/specificity, correlation with cycle threshold value from polymerase chain reaction (PCR), fitness-for-use in different populations and settings, and user perspectives that could inform large-scale implementation. In this study, we evaluated the performance of a rapid antigen detection test, BD Veritor, and compared this (and another rapid test, Standard Q) against reverse transcription PCR (RT-PCR) in terms of sensitivity and specificity in 130 symptomatic and 130 asymptomatic adults. In addition, we evaluated the suitability and ease of use of the BD Veritor test in a subsample of study participants (n = 42) and implementers (n = 5). At 95% confidence interval, the sensitivity of the BD Veritor and Standard Q test were 70% and 63% in symptomatic and 87% and 73% in asymptomatic individuals, respectively, regarding positive SARS-CoV-2 RT-PCR results. Overall, the BD Veritor test was 78% sensitive and 99.5% specific compared with RT-PCR irrespective of the cycle threshold. This warrants large field evaluation as well as use of the rapid antigen test for quick assessment of SARS-CoV-2 for containment of epidemics in the country.
A Machine Vision Identification Technique From Range Images (1988)

In this paper, we have developed an orientation-independent identification technique from three-dimensional surface maps or range images. Given the range image of an object, it is decomposed into orientation-independent patches using the sign of gaussian curvature. A relational graph is then set up such that a node represents a patch and an edge represents the adjacency of two patches. The identification of the object is achieved by matching its graph representation to a number of model graphs. The matching is performed by employing the best-first search strategy. Examples of real range images show the merit of our technique.
Single-Pulse Ultrasonic Proximal Distance Sensor with Thermoacoustic Transmitter (2013)

This paper proposes an ultrasonic proximal distance sensor, which uses a thermoacoustic device as a transmitter. Thermoacoustic transmitter doesn't have mechanical vibration and resonant frequency, thus it can emit a single-pulse ultrasonic, which width is under 10 µsec. Using a single-pulse ultrasonic, overlap of transmitting and receiving term is very short and it can measure very short rage such as 3 mm with excellent accuracy.
Properties of polyoma virus transformed cells. I. Oncogenic properties (1971)

Studies were made on the oncogenic properties of a line of polyoma virus transformed hamster cells. Passage of the cells in vivo resulted in an increase in oncogenicity. Thus the latent period for the appearance of a tumor was decreased, and as few as 5 to 10 cells were now sufficient to produce a tumor in a young hamster. Tumors were invariably restricted to the subcutaneous site of injection. In contrast, polyoma virus itself caused widespread production of tumors throughout the animal. Histological examination of tumor tissue revealed marked differences between tumors caused by virus or virus-transformed cells. It was concluded that little or no metastasis of transformed cells could have occurred, and that insignificant rescue of the polyoma virus genome must have been induced in transformed cell tumors.Powassan virus, a group B arbovirus, did not show any oncolytic activity toward tumors induced by the polyoma virus transformed cells.
Isolation of Myogenic Stem Cells from Cultures of Cryopreserved Human Skeletal Muscle (2012)

We demonstrate that subpopulations of adult human skeletal muscle-derived stem cells, myogenic endothelial cells (MECs), and perivascular stem cells (PSCs) can be simultaneously purified by fluorescence-activated cell sorting (FACS) from cryopreserved human primary skeletal muscle cell cultures (cryo-hPSMCs). For FACS isolation, we utilized a combination of cell lineage markers: the myogenic cell marker CD56, the endothelial cell marker UEA-1 receptor (UEA-1R), and the perivascular cell marker CD146. MECs expressing all three cell lineage markers (CD56(+)UEA-1R(+)CD146(+)/CD45(-)) and PSCs expressing only CD146 (CD146(+)/CD45(-)CD56(-)UEA-1R(-)) were isolated by FACS. To evaluate their myogenic capacities, the sorted cells, with and without expansion in culture, were transplanted into the cardiotoxin-injured skeletal muscles of immunodeficient mice. The purified MECs exhibited the highest regenerative capacity in the injured mouse muscles among all cell fractions tested, while PSCs remained superior to myoblasts and the unpurified primary skeletal muscle cells. Our findings show that both MECs and PSCs retain their high myogenic potentials after in vitro expansion, cryopreservation, and FACS sorting. The current study demonstrates that myogenic stem cells are prospectively isolatable from long-term cryopreserved primary skeletal muscle cell cultures. We emphasize the potential application of this new approach to extract therapeutic stem cells from human muscle cells cryogenically banked for clinical purposes.
The development and characterization of aluminum fueled power systems and a liquid aluminum fuel (2019)

This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.