gebhart/patrepeval huggingface dataset:
Outdoor Experiments on Long-Range and Mobile Communications Using 39-GHz Band for 5G and Beyond (2019)

This paper presents results of outdoor experiments conducted in the 39-GHz band. In particular, assuming mobile communications such as the fifth generation mobile communications (5G) and beyond, we focus on achieving 1Gbit/s or greater throughput at transmission distances exceeding 1km in the experiments. In order to enhance the data rate and capacity, the use of higher frequency bands above 6GHz for mobile communications is a new and important technical challenge for 5G and beyond. To extend further the benefits of higher frequency bands to various scenarios, it is important to enable higher frequency bands to basically match the coverage levels of existing low frequency bands. Moreover, mobility is important in mobile communications. Therefore, we assume the 39-GHz band as a candidate frequency for 5G and beyond and prepare experimental equipment that utilizes lens antenna and beam tracking technologies. In the experiments, we achieve the throughput values of 2.14Gbit/s at the transmission distance of 1850m and 1.58Gbit/s at 20-km/h mobility. Furthermore, we show the possibility of achieving high throughput even under non-line-of-sight conditions. These experimental results contribute to clarifying the potential for the 39-GHz band to support gigabit-per-second class data rates while still providing coverage and supporting mobility over a coverage area with distance greater than 1km.
Review of Experimental Characterization of Active Sites and Determination of Molecular Mechanisms of Adsorption, Desorption and Regeneration of the Deep and Ultradeep Desulfurization Sorbents for Liquid Fuels (2010)

Abstract This review analyzes the recent literature on the direct experimental determination of molecular and atomic-level nature of adsorption sites, mechanisms of adsorption under the mild (close to ambient) conditions, desorption of sulfur-aromatic compounds, and surface chemical reactions upon regeneration of the "spent" sorbents for desulfurization of the liquid fuels. Supported noble, transition metals and metal oxides, binary, and ternary metal oxides, activated carbons, zeolites, supported polymers, pervaporation membranes and other advanced adsorptive desulfurization materials are discussed. The recent trends in developing the deep and ultradeep desulfurization sorbents are discussed, and challenges of the direct determination of molecular mechanisms are described. Keywords: Active sitesDesorptionDesulfurization sorbentsMolecular mechanismsRegeneration ACKNOWLEDGMENT The authors thank the US Army (TACOM LCMC Contract W56HZV-05-C-0686) for the financial support of this work.
Broadly Applicable Z‐ and Diastereoselective Ring‐Opening/Cross‐Metathesis Catalyzed by a Dithiolate Ru Complex (2014)

A broadly applicable Ru-catalyzed protocol for Z-selective ring-opening/cross-metathesis (ROCM) is disclosed. In addition to reactions relating to terminal alkenes of different sizes, the first examples of Z-selective ROCM processes involving heteroaryl olefins, 1,3-dienes, and O- and S-substituted alkenes as well as allylic and homoallylic alcohols are reported. Z-Selective transformations with an α-substituted allylic alcohol are shown to afford congested Z alkenes with high diastereoselectivity. Transformations are performed in the presence of 2.0-5.0 mol % of a recently disclosed Ru-based dithiolate complex that can be easily prepared in a single step from commercially available starting materials. Typically, transformations proceed at ambient temperature and are complete within eight hours; products are obtained in up to 97 % yield, >98:2 Z/E, and >98:2 diastereomeric ratio. The present investigations reveal a mechanistically significant attribute of the Ru-based dithiolates that arises from electrostatic interactions with anionic S-based ligands.
A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium (2007)

Enteropathogenic Escherichia coli induces characteristic attaching-effacing (A/E) lesions on the intestinal mucosa during infection. The locus of enterocyte effacement is essential for A/E lesion formation and encodes a type III secretion system that translocates multiple effector proteins into the host cell. Following translocation, EspI/NleA localizes to the Golgi. Using the yeast two-hybrid system (Y2HS) and PSD-95/Disk-large/ZO-1 (PDZ)-domain protein array overlays, we identified 15 putative host-interacting partners of EspI. All but two of the target proteins contained PDZ domains. Examination of the EspI amino acid sequence revealed a C-terminal consensus class I PDZ binding motif. Deletion of the last 7 amino acids of EspI to generate EspI(DeltaC7) abrogated the Y2HS interaction between EspI and 5 of the 6 putative host cell target proteins tested. Deletion of the EspI PDZ binding motif also resulted in delayed trafficking of EspI to the Golgi. Using a mouse model of infection, we showed that Citrobacter rodentium expressing truncated EspI(DeltaC7) was attenuated when in competition with C. rodentium expressing full-length EspI. Overall, these results suggested that EspI may modulate the virulence of A/E pathogens by binding host PDZ-domain proteins.
Synthesis of Carbocyclic and Heterocyclic Fused Quinolines by Cascade Radical Annulations of UnsaturatedN-Aryl Thiocarbamates, Thioamides, and Thioureas (2003)

[reaction: see text] Tandem radical cyclizations of suitably substituted N-aryl thiocarbamates, thioamides, and thioureas are induced by exposure to tris(trimethylsilyl)silane (TTMSH) and UV light and provide furoquinolines, isofuroquinolines, cyclopentaquinolines, indoloquinolines, and related ring systems. The intermediacy of an alpha-thioalkylamino radical, which is the synthetic equivalent of an imidoyl radical, is invoked.
On Lab Test of Coherence in Event Horizon Imager (2021)

Event horizon imaging requires a third-generation space Very Long Baseline Interferometer on a 500 GHz band. The interferometer challenges available frequency standards. Namely, the practical coherent integration time is about 45 times shorter than needed. A self-calibration could aid this though a 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> satellite is needed hence, an increased mission cost. This paper is devoted to experimental verification of a novel concept for two-way frequency transfer.We built a dedicated breadboard, test set-up, and run tests with and without temperature differences between branches of the breadboard. A phase difference between derived oscillators is the white noise-like function of the time with 1-σ of 0.5° at 103.2 GHz over more than 3 hours. Varying the temperature difference between branches ±3 C during 4.5 hours, being the orbit period, confirmed that the phase difference is the function of this temperature difference too. The Allan Deviation demonstrated between two derived 103.2 GHz oscillators is of 1.1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−14</sup> /τ over 10 ms < τ < 1000 s, where τ is the averaging time, and the optical communication link path length is 5 km (17 ms). Degradation of this Allan Deviation is of 2 times at the longest-possible delay of 0.2 s in the interferometer system; the 0.2 s is the biggest sum of geometric and communication delays. This worst-case satisfies the requirement with a margin of 11 times. An obtained coherence is in the range of 0.997−0.9998 which is beneficial for the interferometer, at 557 GHz. This is one of the key technology enablers for black hole imaging from space.
A multi-centered controlled clinical trial comparing clips to suture for construction of vascular access sites for hemodialysis (1995)

BioGlue Surgical Adhesive (CryoLife, Inc, Kennesaw, GA) is used to reinforce anastomoses during cardiovascular operations. Previous reports have raised concerns that adhesives may leak through suture-line needle holes and that resulting intraluminal glue may embolize. The purpose of this study was to determine if BioGlue leaks through anastomotic needle holes in aortic tissue and two common prosthetic graft materials.Polypropylene suture was used to create end-to-end anastomoses in gelatin-sealed woven polyester grafts (n = 45), expanded polytetrafluoroethylene (ePTFE) grafts (n = 45), and fresh porcine aortas (n = 45). An additional 45 anastomoses were created in ePTFE grafts using ePTFE sutures. The outer surface of each anastomosis was covered with BioGlue. Anastomoses underwent inspection with direct magnification or histology.BioGlue leaked through needle holes and into the lumen in 10% of anastomoses (18 of 180). Leaks were significantly more common in fresh aorta (10 of 45, 22%) than in prosthetic grafts (8 of 135, 6%; p = 0.003). Suture size did not significantly affect the incidence of leak. The use of ePTFE sutures did not eliminate BioGlue leakage. Prosthetic graft leaks created discreet round adhesive particles. In contrast, aortic tissue leaks resulted in thin, friable flakes of glue extending along the intimal surface. Aortic histology confirmed that BioGlue reached the vessel lumen via the suture channels.BioGlue leaked through the needle holes in fresh aortic tissue and prosthetic grafts. Intraluminal adhesive particles were easily dislodged, supporting concerns regarding embolization. The potential for adhesive embolization should be a factor when considering the relative risks and benefits of using BioGlue.
Fluorescent labeling of major honeybee allergens Api m 1 and Api m 2 with quantum dots and the development of a multiplex basophil activation test (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Templated growth of graphenic materials (2009)

A novel strategy is proposed for the topologically controlled synthesis of extended graphenic sheets by additively reacting carbon into a pre-existing graphene sheet which is on top of a templating substrate. This concept is implemented and demonstrated using chemical vapor deposition (CVD). Novel morphological features observed in this study suggest unusual aspects of the CVD growth process. CVD results demonstrate the basic soundness of the synthesis strategy but highlight the sensitivity of the process to certain types of disruption and the need for alternative forms of embodiment.
Assessing the value of delandistrogene moxeparvovec (SRP-9001) gene therapy in patients with Duchenne muscular dystrophy in the United States (2023)

<b>Background</b>: Delandistrogene moxeparvovec (SRP-9001) is an investigational gene therapy that may delay progression of Duchenne muscular dystrophy (DMD), a severe, rare neuromuscular disease caused by <i>DMD</i> gene mutations. Early cost-effectiveness analyses are important to help contextualize the value of gene therapies for reimbursement decision making. <b>Objective</b>: To determine the potential value of delandistrogene moxeparvovec using a cost-effectiveness analysis. <b>Study design</b>: A simulation calculated lifetime costs and equal value of life years gained (evLYG). Inputs included extrapolated clinical trial results and published utilities/costs. As a market price for delandistrogene moxeparvovec has not been established, threshold analyses established maximum treatment costs as they align with value, including varying willingness-to-pay up to $500,000, accounting for severity/rarity. <b>Setting</b>: USA, healthcare system perspective <b>Patients</b>: Boys with DMD <b>Intervention</b>: Delandistrogene moxeparvovec plus standard of care (SoC; corticosteroids) versus SoC alone <b>Main outcome measure</b>: Maximum treatment costs at a given willingness-to-pay threshold <b>Results</b>: Delandistrogene moxeparvovec added 10.30 discounted (26.40 undiscounted) evLYs. The maximum treatment cost was approximately $5 M, assuming $500,000/evLYG. Varying the benefit discount rate to account for the single administration increased the estimated value to #$5M, assuming $500,000/evLYG. <b>Conclusion</b>: In this early economic model, delandistrogene moxeparvovec increases evLYs versus SoC and begins to inform its potential value from a healthcare perspective.
Input vector control for post-silicon leakage current minimization in the presence of manufacturing variability (2008)

We present the first approach for post-silicon leakage power reduction through input vector control (IVC) that takes into account the impact of the manufacturing variability (MV). Because of the MV, the integrated circuits (ICs) implementing one design require different input vectors to achieve their lowest leakage states. We address two major challenges. The first is the extraction of the gatelevel characteristics of an IC by measuring only the overall leakage power for different inputs. The second problem is the rapid generation of input vectors that result in a low leakage for a large number of unique ICs that implement a given design, but are different in the post-manufacturing phase. Experimental results on a large set of benchmark instances demonstrate the efficiency of the proposed methods. For example, the leakage power consumption could be reduced in average by more than 10.4%, when compared to the previously published IVC techniques that did not consider MV.
Selective Intermodulation Compensation in a Multi-Stage Digital Predistorter for Nonlinear Multi-Band Power Amplifiers (2017)

This paper presents a technique for suppressing the intermodulation distortion caused by nonlinear multi-band power amplifiers with minimal modeling complexity. The technique is based on generating a narrowband static predistorter for the power amplifier. Then, the intended multi-band signals are resampled and shifted into their representative carrier frequencies before applying the static predistorter in order to accommodate the intermodulation distortion products produced by the nonlinearity. Since the resampling frequency may be high, a study is presented, using filtering techniques to represent low-bandwidth transmitter schemes, to show the accuracy of the intermodulation distortion suppression. Results are presented for the proposed predistorter for two amplifiers: one in a tri-band carrier aggregated LTE scenario in the sub 3 GHz frequencies and another in the millimeter-wave band, demonstrating the effectiveness of reducing the intermodulation products using 5G signals.
Preliminary Characterization of Bioreactivity of Novel Carbonaceous Pitches Extracted in N-Methylpyrrolidone (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreliminary Characterization of Bioreactivity of Novel Carbonaceous Pitches Extracted in N-MethylpyrrolidoneC. S. Cohen, P. G. Stansberry, A. H. Stiller, G. Hobbs, K. Vavro, and M. R. MillerCite this: Energy Fuels 1995, 9, 6, 1051–1057Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ef00054a018https://doi.org/10.1021/ef00054a018research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rapid Levodopa Augmentation Following Inhaled CVT-301 Results in Rapid Improvement in Motor Response When Administered to PD Patients in the OFF State (S7.007) (2014)

OBJECTIVE: To evaluate levodopa pharmacokinetics (PK) and pharmacodynamics following CVT-301 inhalation in PD patients with motor fluctuations. BACKGROUND: Variability in oral levodopa absorption and pharmacokinetics (PK) contributes to the development of OFF states, the major problem of levodopa-treated PD patients. In nonclinical models, following intrapulmonary delivery, levodopa was more rapidly absorbed and PK was less variable, resulting in rapid motor function improvement. CVT-301, a dry powder inhaled levodopa formulation is being developed for the treatment of intermittent OFF episodes. DESIGN/METHODS: This was a double-blind (DB), placebo-controlled, crossover study of CVT-301 in 24 PD motor fluctuators experiencing >2hr/day OFF time. Subjects received single doses of study drug ~4-5hrs following usual morning oral PD medications, following their first OFF. Open-label oral Sinemet™ (25/100mg) was administered on the first treatment day; DB inhaled CVT-301 (25mg and 50mg levodopa fine particle dose [FPD]) or placebo were administered randomly on days 2, 3 and 4. Levodopa concentrations [levodopa], motor response (timed tapping, UPDRS III) and safety were evaluated over 3hrs postdose. RESULTS: Baseline-adjusted levodopa Cmax and AUC increased dose proportionally. Incremental [levodopa] following inhaled CVT-301 (50 mg FPD) approached therapeutically-relevant increments by 5min (mean baseline adjusted Cmax 698 ng/mL). Levodopa variability was considerably lower following CVT-301 than with oral Sinemet. Timed tapping and UPDRS responses were dose-ordered. Relative to placebo, only CVT-301 50 mg FPD resulted in statistically significant improvements in average and maximal changes in timed tapping and UPDRS; onset of motor response improvement was observed at 5min post-dose. There was no increase in frequency or severity of dyskinesia. CVT-301 was generally safe and well tolerated. There were no adverse events resulting in discontinuation or serious AEs. There were no adverse changes in spirometry measures at either inhaled CVT-301 dose. CONCLUSIONS: Inhaled CVT-301 rapidly augments [levodopa] and results in rapid motor function improvement in PD patients experiencing an OFF episode. Study Supported by: Grant from the Michael J. Fox Foundation for Parkinson's Research
Coupling Polymorphism/Solvatomorphism and Physical Stability Evaluation with Early Salt Synthesis Optimization of an Investigational Drug (2011)

The need for effective solid-form screening approaches, especially designed for the early discovery phases, is well recognized within the pharmaceutical industry. Here we report on the early polymorphism and solvatomorphism evaluation of a new drug candidate for selective α2C-adrenoceptor antagonists ORM10921·HCl. The approach we use is based on the systematic batch-to-batch characterization of the solids generated during the salt synthesis optimization. Within this study three crystalline forms, two anhydrous and one hemihydrate, were discovered and identified by X-ray powder diffraction (XRPD), differential scanning calorimery (DSC), and thermal gravimetry (TGA). Moreover, coupling the gravimetric vapor sorption analysis with a conventional XRPD enabled the relative stability of these solid-state forms at ambient conditions to be established and the most stable form, the hemihydrate, to be selected for further development. Hence, the utilized approach has proven to be an effective and fast tool for initial polymorphism and solvatomorphism tendency evaluation of drug candidates. While it is not obvious that this approach is sufficient for a comprehensive assessment of polymorphism, it demonstrates the importance of mindful solid-state characterization during crystallization process development.
Time synchronization mechanisms for the industrial marketplace (2015)

This paper investigates heavy industry power distribution systems and identifies a need for time synchronization within the network. Various methods of time synchronization are presented with pros and cons to each method. The goal of this paper is to educate the reader of various forms of time synchronization and how they can be applied in their industrial application.
Neuronal activity under transcranial radio-frequency stimulation in metal-free rodent brains in-vivo (2022)

As the use of Radio Frequency (RF) technologies increases, the impact of RF radiation on neurological function continues to receive attention. Whether RF radiation can modulate ongoing neuronal activity by non-thermal mechanisms has been debated for decades. However, the interactions between radiated energy and metal-based neural probes during experimentation could impact neural activity, making interpretation of the results difficult. To address this problem, we modified a miniature 1-photon Ca<sup>2+</sup> imaging device to record interference-free neural activity and compared the results to those acquired using metal-containing silicon probes. We monitored the neuronal activity of awake rodent-brains under RF energy exposure (at 950 MHz) and in sham control paradigms. Spiking activity was reliably affected by RF energy in metal containing systems. However, we did not observe neuronal responses using metal-free optical recordings at induced local electric field strengths up to 230 V/m. Our results suggest that RF exposure higher than levels that are allowed by regulatory limits in real-life scenarios do not affect neuronal activity.
Induction of Apoptosis and G2/M Cell Cycle Arrest by Cordycepin in Human Prostate Carcinoma LNCap Cells (2014)

Cordycepin은 Cordyceps militaris에서 처음 유래된 nucleoside adenosine 유도체의 일종으로 면역증강 및 항암활성을 포함한 다양한 약리 기능이 있는 것으로 알려져 있다. 본 연구에서는 LNCap 인체 전립선 암세포 모델을 이용하여 cordycepin에 의한 항암활성 기전을 연구하였다. Cordycepin 처리에 따라 LNCap 세포는 처리 농도 의존적으로 증식이 억제되었으며, 이는 apoptosis 유발과 연관성이 있음을 poly ADP-ribose polymerase의 단편화 현상과 Annexin V 염색에 의한 정량적 분석으로 확인하였다. Cordycepin 처리에 따른 flow cytometric analysis 결과로서 cordycepin이 세포주기 G2/M기 정체 현상을 유발하였음을 알 수 있었으며, 이는 cyclin B1 및 cyclin A의 발현 감소와 연관성이 있었다. 또한 cordycepin이 처리된 LNCap 세포에서 cyclin-dependent kinase (CDK) inhibitor p21Waf1/Cip1의 발현이 증가되었지만, CDK2, CDC2 및 Cdc25C의 발현에는 큰 영향을 미치지 않았으며, cordycepin에 의하여 증가된 p21 단백질은 CDK2 및 CDC2와의 복합체를 형성하고 있었다. 본 연구의 결과는 LNCap 전립선 암세포에서 cordycepin에 의한 G2/M 및 apoptosis 유발은 p53 비존적인 CDK inhibitor p21의 발현 증가가 중요한 역할을 하고 있음을 보여주는 것이다. Cordycepin, an active component originally isolated from the traditional medicine Cordyceps militaris, is a derivative of the nucleoside adenosine, which has been shown to possess a number of pharmacological properties, including antioxidant and anti-inflammatory activities, immunological stimulation, and antitumor effects. This study was conducted on cultured human prostate carcinoma LNCap cells to elucidate the possible mechanisms by which cordycepin exerts its anticancer activity, which, until now, has remained poorly understood. Cordycepin treatment of LNCap cells resulted in dose-dependent inhibition of cell growth and the induction of apoptotic cell death as detected by an MTT assay, cleavage of poly ADP-ribose polymerase, and annexin V-FITC staining. Flow cytometric analysis revealed that cordycepin resulted in G2/M arrest in cell cycle progression and downregulation of cyclin B1 and cyclin A expression in a concentration-dependent manner. Moreover, the incubation of cells with cordycepin caused a striking induction in the expression of the cyclin-dependent kinase (CDK) inhibitor p21Waf1/Cip1 without affecting the expression of the tumor suppressor p53. It also resulted in a significant increase in the binding of CDK2 and CDC2 to p21. These findings suggest that cordycepin-induced G2/M arrest and apoptosis in human prostate carcinoma cells is mediated through p53-independent upregulation of the CDK inhibitor p21.