gebhart/patrepeval huggingface dataset:
Trust-Based Fast Authentication for Multiowner Wireless Networks (2008)

In multiowner wireless networks, access points (APs) are owned and operated by different administrations, leading to significant authentication delays during handoff between APs. We propose to exploit the trust between the owners of neighboring APs for reducing the authentication delay. In the proposed authentication scheme, neighboring APs that trust each other share the security key for the visiting node to avoid lengthy authentication routines each time the visiting node switches APs. The performance of the proposed trust-based authentication scheme is evaluated using a Markov model. Using numerical experiments, we first study a basic scenario where mobile nodes are not aware of the trust networks that exist in a given neighborhood. Subsequently, we consider an advanced scenario where a mobile node functionality is augmented to discover the trust network so as to minimize roaming beyond the trusted APs. We find that, even with the basic implementation, the average number of full authentications needed for a roaming mobile reduces linearly as the likelihood of two neighboring APs trusting each other increases. With the advanced implementation, our experiments show that quadratic reduction is achieved. The Markov model is validated using discrete event simulation.
Simulation-based Design and Validation of Automated Contingency Management for Propulsion Systems (2007)

Automated contingency management (ACM), or the ability to confidently and autonomously adapt to fault and/or contingency conditions with the goal of still achieving mission objectives, can be considered the ultimate technological goal of a health management system. To establish confidence on the ACM system, objective performance evaluations should be executed. The need for verification and validation (V&V) techniques for ACM has also been specifically identified by DOD agencies and within the NASA community recently. This paper presents a general process and related techniques for developing and validating ACM systems for advanced propulsion systems. A novel ACM modeling paradigm, optimization-based ACM strategies, V&V approaches and performance metrics are developed. While some well-established formal methods such as model checking techniques are applicable to some sub-problems, this research has been more focused on innovative informal methods that attempt to address ACM performance requirements, optimality, robustness, etc. A pressure fed, monopropellant propulsion system for a small space flight vehicle is utilized as initial proof-of-concept implementation for the proposed techniques and preliminary simulation results are presented.
Finger-STS: Combined Proximity and Tactile Sensing for Robotic Manipulation (2022)

This paper introduces and develops novel touch sensing technologies that enable robots to better sense and react to to intermittent contact interactions. We present Finger-STS, a robotic finger embodiment of the See-Through-your-Skin (STS) sensor that can capture 1) an “in the hand” visual perspective of an object that is being manipulated and 2) a high resolution tactile imprint of the contact geometry. We demonstrate the value of the sensor on a Bead Maze task. Here the multimodal feedback provided by the Finger-STS is leveraged by a robot to locate a bead visually and to guide it across a wire in response to tactile cues, with no additional sensing or planning required. To achieve this, we introduce a set of relevant visuotactile operations using computer vision-based algorithms. In particular, we sense the proximity of the object relative to the sensor as well as the nature of contact as a high resolution stick/slip vector field tracking the object motion in the finger.
Metal/AlQ 3 interface structures (2002)

X-ray photoelectron core level spectroscopy has been used to probe the buried metal (Au, Ag, Mg, Mg:Ag alloy)/AlQ3 interface structures from working organic light-emitting diodes. It is found that there is no chemical reaction between (Au,Ag)/AlQ3 interfaces, while there is a significant reaction/diffusion at (Mg,Mg:Ag)/AlQ3 interfaces. The reaction is AlQ3 oxidation-reduction reaction in nature, and is well explained by thermodynamic consideration of equivalent type of reaction. The reaction involves formation of MgO, metallic Al and fragmented hydroxyquinolines, gaseous N, and then followed by metallic Mg diffusion to the interface and metallic Al diffusion into the metal cathodes.
An Integrated Approach to Monitoring a Field Test ofIn SituContaminant Destruction (1999)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 1999An Integrated Approach to Monitoring a Field Test of In Situ Contaminant DestructionAuthors: Robin L. NewmarkRoger D. AinesG. Bryant HudsonRoald LeifMarina ChiarappaCharles CarriganJohn J. NitaoAllen ElsholzCraig EakerRobin L. NewmarkLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, Roger D. AinesLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, G. Bryant HudsonLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, Roald LeifLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, Marina ChiarappaLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, Charles CarriganLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, John J. NitaoLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, Allen ElsholzLawrence Livermore National Laboratory, Livermore, CA, 94550, USA, and Craig EakerSouthern California Edison Company, Rosemead, CA., 91770, USAhttps://doi.org/10.4133/1.2922648 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2922648FiguresReferencesRelatedDetailsCited byA survey of current trends in near-surface electrical and electromagnetic methodsEsben Auken, Louise Pellerin, Niels B. Christensen, and Kurt Sørensen7 September 2006 | GEOPHYSICS, Vol. 71, No. 5 Symposium on the Application of Geophysics to Engineering and Environmental Problems 1999ISSN (online):1554-8015Copyright: 1999 Pages: 997 publication data© 1999 Copyright © 1999 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished Online: 30 Sep 2008 CITATION INFORMATION Robin L. Newmark, Roger D. Aines, G. Bryant Hudson, Roald Leif, Marina Chiarappa, Charles Carrigan, John J. Nitao, Allen Elsholz, and Craig Eaker, (1999), "An Integrated Approach to Monitoring a Field Test of In Situ Contaminant Destruction," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : 527-539. https://doi.org/10.4133/1.2922648 Plain-Language Summary PDF DownloadLoading ...
Ultrasound-Mediated Transdermal Drug Delivery (2008)

The skin (cutis) is not only the largest organ, with a total weight around 3 kg and a surface of approximately 2.0m2 in humans, it is also the best and most easily accessible body part. Transcutaneous drug delivery has therefore been tried innumerable times. The problem with the approach is that most drugs cannot successfully diffuse through (permeate) intact skin. This is due to special structural, biochemical, and physiological properties of the organ, especially in its outermost 8-30mm thin layer (the stratum corneum), which has evolved into the primary skin barrier, one of the best in nature (Fig. 1, left).
Expectation of photon multiplicity in p-p collisions at LHC energies (2011)

The measurements of pseudorapidity distributions of produced particles are important to understand the particle production mechanisms, the scaling laws and the limiting fragmentation behavior. The Large Hadron Collider (LHC) at CERN can provide protonproton collisions at center of mass energies 0.9 TeV to 14 TeV. The measurements of pseudorapidity distribution of produced particles can be used to test the particles production mechanism implemented in different models like PYTHIA [1], PHOJET [2]. In this article We have compiled the data on pseudorapidity distribution of inclusive photons of UA5 [3] experiment. The pseudorapidity distribution of photons is parameterazied using a function with same physical motivation and it is used to predict [4] the distribution at higher LHC energies.
Carboxylic acids as an oxolation source for the synthesis of titanium oxo organo clusters (2001)

Abstract Three titanium oxo-isopropoxo clusters [Ti6O4(OAc)4(OPr1)12] (1) and [Ti12O16(OPr1)16] (2) and [Ti17O24(OPri)20](3) are (3) are obtained by a solvothermal approach which does not involve the direct hydrolysis of titanium alkoxide precursor. Water is generated in-situ through esterification reactions induced by acetic acid. The molecular structures of these complexes have been resolved by single crystal X-ray diffraction. The nuclearity of these clusters increases with acetic acid/Ti ratio and temperature.
Storage systems for transportation, land handling and naval applications (2012)

A confluence of industry, social, environmental and economical drivers is creating new interest in electric energy storage systems. The limitation in the energy resources availability, the continuing increasing of the fossil fuels cost and the more attention to the earth ecosystem, is making storage systems a suitable solution in many applications ranging from grid application toward the industrial and transportation ones. In this paper a review of actual electrical storage technologies suitable for transportation and naval applications is provided with particular attention to the functionalities that is possible to introduce according to the selected technology. Moreover, the applications of storage systems in land and naval handling will be analyzed in details underlining the advantages deriving by the introduction of opportunely chosen storage units.
Transparent Tx and Rx Waveform Processing for 5G New Radio Mobile\n Communications (2018)

Several different waveform processing techniques have been studied and\nproposed for the 5G new radio (NR) physical layer, to support new mixed\nnumerology and asynchronous services. The evaluation and comparison of these\ndifferent techniques is commonly based on matched waveform processing in the\ntransmitter and receiver units. In this article, it is shown that different\ntechniques can be flexibly mixed, allowing to separately optimize\ncomplexity-performance trade-offs for transmitter and receiver implementations.\nMixing of different waveform processing techniques is possible by setting\nadequate requirements for transmitter and receiver baseband processing allowing\ntransparent design. The basic framework of how transmitter and receiver units\ncan be independently applied and evaluated in the context of transparent design\nand an extensive set of examples of the achievable radio link performance with\nunmatched transmitter and receiver waveform processing are provided. The\ndiscussed approach and solutions simplify standardization, improve transparent\ntransmitter and receiver coexistence, and allow future-proof evolution path for\nperformance improvements in 5G NR physical layer hardware and algorithm design.\n
Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy (2012)

Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually screened the tertiary Metnase structure against the 550,000 compound ChemDiv library to identify small molecules that might dock in the active site of the transposase nuclease domain of Metnase. We identified eight compounds as possible Metnase inhibitors. Interestingly, among these candidate inhibitors were quinolone antibiotics and HIV integrase inhibitors, which share common structural features. Previous reports have described possible activity of quinolones as antineoplastic agents. Therefore, we chose the quinolone ciprofloxacin for further study, based on its wide clinical availability and low toxicity. We found that ciprofloxacin inhibits the ability of Metnase to cleave DNA and inhibits Metnase-dependent DNA repair. Ciprofloxacin on its own did not induce DNA damage, but it did reduce repair of chemotherapy-induced DNA damage. Ciprofloxacin increased the sensitivity of cancer cell lines and a xenograft tumor model to clinically relevant chemotherapy. These studies provide a mechanism for the previously postulated antineoplastic activity of quinolones, and suggest that ciprofloxacin might be a simple yet effective adjunct to cancer chemotherapy.
Prospective, Multicenter Study of Spinal Cord Stimulation for Relief of Chronic Back and Extremity Pain (1996)

This prospective, multicenter study confirms that spinal cord stimulation can be an effective therapy for management of chronic low back and extremity pain. Significant improvements in many aspects of the pain condition were measured, and complications were minimal.
ChemInform Abstract: Synthetic Approach to Pentaleno(2,1‐b:5,4‐b′)diindoles. (1990)

Abstract Combined Weiss reaction and Fischer indole‐cyclization of the bicyclooctanedione (I) with phenylhydrazine (II) yield the dihydropentalenodiindole (III) which is further transformed into the N‐methyl derivative (V).
Molecular mechanisms and hormonal regulation underpinning morphological dormancy: a case study using Apium graveolens (Apiaceae) (2021)

SUMMARY Underdeveloped (small) embryos embedded in abundant endosperm tissue, and thus having morphological dormancy (MD) or morphophysiological dormancy (MPD), are considered to be the ancestral state in seed dormancy evolution. This trait is retained in the Apiaceae family, which provides excellent model systems for investigating the underpinning mechanisms. We investigated Apium graveolens (celery) MD by combined innovative imaging and embryo growth assays with the quantification of hormone metabolism, as well as the analysis of hormone and cell‐wall related gene expression. The integrated experimental results demonstrated that embryo growth occurred inside imbibed celery fruits in association with endosperm degradation, and that a critical embryo size was required for radicle emergence. The regulation of these processes depends on gene expression leading to gibberellin and indole‐3‐acetic acid (IAA) production by the embryo and on crosstalk between the fruit compartments. ABA degradation associated with distinct spatiotemporal patterns in ABA sensitivity control embryo growth, endosperm breakdown and radicle emergence. This complex interaction between gibberellins, IAA and ABA metabolism, and changes in the tissue‐specific sensitivities to these hormones is distinct from non‐MD seeds. We conclude that the embryo growth to reach the critical size and the associated endosperm breakdown inside MD fruits constitute a unique germination programme.
ChemInform Abstract: PREPARATION OF ALKYL ARYL SULFIDES VIA PHASE‐TRANSFER CATALYZED DISPLACEMENT OF AROMATIC CHLORIDE BY ALKYL THIOLATES (1984)

Abstract Die im Formelschema zusammengestellten Substitutionsreaktionen an Chlorbenzolen werden unter Phasen‐Transfer‐Bedingungen untersucht.
Bounds for Binary Codes that are Multiple Coverings of the Farthest-Off Points (1995)

A binary code $C \subseteq \mathbb{F}_2^n$ with M codewords is called an $( n,M,r,u )$ multiple covering of the farthest-off points (MCF) if the Hamming spheres of radius r centered at the codewords cover the whole space $\mathbb{F}_2^n $ and every $x \in \mathbb{F}_2^n $ such that $d( x,C ) = r$ is covered by at least $\mu $ codewords. The minimum possible cardinality $F( n,r,\mu )$ of such a code is studied and tables of upper bounds on $F ( n,r,\mu )$ for $n \leq 16,r \leq 4,\mu \leq 4$ are given.
Flow of a falling film into a pool (1978)

Abstract Complete interfacial profiles are generated for the gravity flow of a thin film into a stagnant pool. The profiles show standing waves and a rapid thinning of the film just above the static meniscus over the pool. Such effects are encountered, for example, at the bottom of wetted wall columns.
Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1β (2009)

Caspase 1 deficiency does not affect neutrophil-dominated joint inflammation, whereas in chronic arthritis, the lack of caspase 1 results in reduced joint inflammation and cartilage destruction. These findings suggest that inhibitors of caspase 1 are not able to interfere with the whole spectrum of IL-1beta production, and therefore such inhibitors may be of therapeutic value only in inflammatory conditions in which limited numbers of neutrophils are present.
Resonance Ion Ejection (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
High-quality reference genome for Clonorchis sinensis (2021)

The Chinese liver fluke, Clonorchis sinensis, causes the disease clonorchiasis, affecting ~35 million people in regions of China, Vietnam, Korea and the Russian Far East. Chronic clonorchiasis causes cholangitis and can induce a malignant cancer, called cholangiocarcinoma, in the biliary system. Control in endemic regions is challenging, and often relies largely on chemotherapy with one anthelmintic, called praziquantel. Routine treatment carries a significant risk of inducing resistance to this anthelmintic in the fluke, such that the discovery of new interventions is considered important. It is hoped that the use of molecular technologies will assist this endeavour by enabling the identification of drug or vaccine targets involved in crucial biological processes and/or pathways in the parasite. Although draft genomes of C. sinensis have been published, their assemblies are fragmented. In the present study, we tackle this genome fragmentation issue by utilising, in an integrated way, advanced (second- and third-generation) DNA sequencing and informatic approaches to build a high-quality reference genome for C. sinensis, with chromosome-level contiguity and curated gene models. This substantially-enhanced genome provides a resource that could accelerate fundamental and applied molecular investigations of C. sinensis, clonorchiasis and/or cholangiocarcinoma, and assist in the discovery of new interventions against what is a highly significant, but neglected disease-complex.
Redox‐Dependent Hepatocyte TNFα Secretion Following Reoxygenation Injury (2013)

Cell line studies have previously shown that hypoxia/reoxygenation (H/R) leads to the production of NADPH Oxidase 1 and 2 (NOX1 and NOX2)‐dependent reactive oxygen species (ROS) required for the activation of c‐Src and NFκB. We now extend these studies into mouse models to evaluate the contribution of hepatocytes to the NOX‐ and c‐Src‐dependent TNFα production that follows H/R and liver ischemia/reperfusion (I/R). In vitro , c‐Src‐knockout (KO) primary hepatocytes produced less ROS and TNFα following H/R than controls. In vivo , c‐Src KO mice also had impaired TNFα and NFκB responses following partial liver I/R. We found that NOX1 and p47 phox are partially required for H/R‐mediated TNFα production by primary hepatocytes. In vivo experiments in KO mice deficient for NOX1, NOX2, p47 phox , Rac1, and/or Rac2 showed that compared to controls, all of these KO mice, except NOX1 KO, had significantly decreased serum TNFα after I/R injury. These results demonstrate that NOX2 and its activator subunits p47 phox and Rac control liver secretion of TNFα following I/R. Interestingly, NOX1 played a major role in secretion of TNFα by primary hepatocytes following in vitro H/R, but not following in vivo I/R. Thus, NOX2 can compensate for loss of NOX1 in vivo . We conclude that c‐Src and NADPH oxidase components are necessary for redox‐mediated production of TNFα following liver I/R and that hepatocytes play an important role in this process.
Spectral properties of angled-grating high-power semiconductor lasers (1999)

We study the spectral properties of angled-grating high-power semiconductor lasers, also known as /spl alpha/ distributed feedback (DFB) lasers. We have derived a closedform expression to describe the cavity resonance. The results of this model are shown to compare favorably with experimental data. Intrinsic device parameters such as coupling coefficient and grating period are shown to be correlated to spectral and nearfield characteristics. The formulations and insights developed in this paper allow one to calculate these critical design parameters for optimum performance.
Living polymerization of methacrylic esters with aluminium porphyrin initiators. Axial ligand exchange activities of alkyl‐ and enolate‐aluminium porphyrins in relation to the polymerization Mechanism (1995)

Abstract Polymerization of methacrylic esters such as benzyl methacrylate using as initiator an‐equimolar mixture of methylaluminium 5,10,15,20‐tetraphenylporphine [(TPP)AlMe] and 2,7,12,17‐tetramethyl‐3,8,13,18‐tetramethylporphine [(EtioP)AlMe] proceeded from both initiators, affording a unimodal polymer of narrow molecular weight distribution, although the reactivities of (TPP)AlMe and (EtioP)AlMe are very different from each other. 1 H NMR studies on a mixture of two different (porphinato)aluminium enolates, the growing species, and a mixture of a (porphinato)aluminium enolate and an alcoholate, in the absence and presence of methyl methacrylate (MMA or MMA‐ d 8 ), indicated an acyclic transition state polymerization mechanism by the participation of two aluminium porphyrin molecules, where the growing species always exchange their enolate ligands whenever it grows.
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1 (2011)

Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibition of DGAT-1 may represent an attractive target for the treatment of obesity or type II diabetes. Herein, we report the discovery and characterization of a potent and selective DGAT-1 inhibitor PF-04620110 (3). Compound 3 inhibits DGAT-1 with an IC50 of 19 nM and shows high selectivity versus a broad panel of off-target pharmacologic end points. In vivo DGAT-1 inhibition has been demonstrated through reduction of plasma triglyceride levels in rodents at doses of ≥0.1 mg/kg following a lipid challenge. On the basis of this pharmacologic and pharmacokinetic profile, compound 3 has been advanced to human clinical studies.
The Impact of Cancer on the Clinical Outcome of Patients After Inferior Vena Cava Filter Placement (2014)

Cancer patients have elevated risks of thrombotic complications compared with noncancer patients; however, these risks are not higher than expected based on historical controls.