gebhart/patrepeval huggingface dataset:
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models (2020)

Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lining the arterial lumen. Here, using zebrafish embryos and endothelial cell models, we describe an alternative, flow independent model, involving enlargement of arterial endothelial cells, which results in the formation of large diameter arteries. Endothelial enlargement requires the GEF1 domain of the guanine nucleotide exchange factor Trio and activation of Rho-GTPases Rac1 and RhoG in the cell periphery, inducing F-actin cytoskeleton remodeling, myosin based tension at junction regions and focal adhesions. Activation of Trio in developing arteries in vivo involves precise titration of the Vegf signaling strength in the arterial wall, which is controlled by the soluble Vegf receptor Flt1.
Supply and demand: Will we have enough vascular surgeons by 2030? (2015)

The increase in prevalence of certain cardiovascular risk factors increases susceptibility to vascular disease, which may create demand for surgical intervention. In our study, data collected by the American Association of Medical Colleges Physician Specialty Databook of 2012, the United States Census Bureau, and other nationwide organizations were referenced to calculate future changes in vascular surgeon supply and prevalence of people at risk for vascular disease. In 2010, there were 2853 active vascular surgeons. By 2040, the workforce is expected to linearly rise to 3573. There will be an exponential rise in people with cardiovascular risk factors. Adding to concern, in 2030, an estimated 3333 vascular surgeons will be available for 180,000,000 people with at least one risk factor for peripheral arterial disease. The paucity of properly trained surgeons entering the workforce needs to be addressed before this shortage becomes a larger burden on healthcare providers and governmental spending.
ChemInform Abstract: New Indolium and Quinolinium Dyes Sensitive to Aqueous Halide Ions at Physiological Concentrations. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Platinum Supported on NbRuyOz as Electrocatalyst for Ethanol Oxidation in Acid and Alkaline Fuel Cells (2011)

Platinum supported on a mixed metal oxide, NbRuyOz (8Nb:1Ru), was evaluated as an electrocatalyst for the ethanol oxidation reaction (EOR) in 0.1 M HClO4 and 1 M KOH. The support was synthesized from a liquid precursor solution of metal chlorides that was aerosolized and thermally decomposed into a powder via the spray pyrolysis (SP) process. Two samples were of primary interest: 30%Pt deposited onto the support by dry impregnation and 60%Pt as part of the precursor solution that underwent in situ SP Pt dispersion. TEM, SEM, and XRD were used to confirm morphology and deposition of Pt. XPS and XAS studies confirmed elemental distribution and oxidation state of Pt catalyst. In situ IRRAS studies in 0.1 M HClO4 show that these electrocatalysts are capable of facilitating the complete oxidation pathway of EOR, involving scission of the C−C bond and CO oxidation.
Genome‐wide Association Study of Agronomic Traits in a Spring‐Planted North American Elite Hard Red Spring Wheat Panel (2018)

Inbred cultivars and advanced breeding lines have been subjected to numerous recombination cycles, have strong allelic selection for desired traits, and share important attributes for adaptation and agronomic performance. Genetic variation in elite gene pools captured using molecular markers is immediately useful for cultivar development. The primary goal of this study was to implement a genome‐wide association study for 17 agronomic traits using elite inbred lines. A panel consisting of 237 elite hard red spring wheat ( Triticum aestivum L.) lines from different wheat breeding institutions in North America were evaluated in 11 locations over 2 yr. A total of 19,192 polymorphic single‐nucleotide polymorphism (SNP) markers from the Illumina 90K SNP array and markers linked to major genes controlling plant height, photoperiod sensitivity, and vernalization were used to assay the population. Linkage disequilibrium was observed to decay within a map distance of ∼3 cM in the A and B genomes and 7 cM in the D genome. A total of 226 marker‐trait associations were identified. Potentially novel associations were detected for grain yield on chromosome 2B and kernels per spike on 1B and 7D, whereas others colocalized with well‐known adaptation loci for photoperiod response, vernalization, and plant height. The frequency of positive alleles for specific marker‐trait associations differed among the programs, suggesting targets for introgression by the respective breeding programs.
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion (2018)

Microbial aromatic catabolism offers a promising approach to convert lignin, a vast source of renewable carbon, into useful products. Aryl-O-demethylation is an essential biochemical reaction to ultimately catabolize coniferyl and sinapyl lignin-derived aromatic compounds, and is often a key bottleneck for both native and engineered bioconversion pathways. Here, we report the comprehensive characterization of a promiscuous P450 aryl-O-demethylase, consisting of a cytochrome P450 protein from the family CYP255A (GcoA) and a three-domain reductase (GcoB) that together represent a new two-component P450 class. Though originally described as converting guaiacol to catechol, we show that this system efficiently demethylates both guaiacol and an unexpectedly wide variety of lignin-relevant monomers. Structural, biochemical, and computational studies of this novel two-component system elucidate the mechanism of its broad substrate specificity, presenting it as a new tool for a critical step in biological lignin conversion.
Synthesis of Lipophilic Clovamide Derivatives and Their Antioxidative Potential against Lipid Peroxidation (2003)

Some N-(hydroxycinnamoyl)-L-tyrosine and L-DOPA alkyl esters were synthesized and evaluated as a variation of the clovamide (N-caffeoyl-L-3,4-dihydroxyphenylalanine) structure, a known antioxidant found in red clover. The amides were prepared in good yields starting from methyl and dodecylesters of L-tyrosine and L-DOPA by reacting with the N-hydroxysuccinimidyl esters of ferulic, sinapic, and acetyl-protected caffeic acid, respectively. In the DPPH* (2,2-diphenyl-1-picrylhydrazyl) and superoxide radical quencher assays they showed radical scavenging activity equal to or higher than those of the standard antioxidants ascorbic acid and tocopherol. The antioxidative potentials of the clovamide derivatives against bulk lipid oxidation, as determined by the accelerated autoxidation of oils, were equal to or higher than those of the standard antioxidants; some of the compounds were able to protect an emulsion of linoleic acid/beta-carotene against oxidation. N-Caffeoyl L-tyrosine methyl ester and the N-cinnamoyl L-DOPA alkyl esters especially were potent antioxidants in bulk lipids and moderate protectants in emulsions.
Targets development at Sandia National Laboratories (2002)

Summary form only given. For many years, Sandia National Laboratories under contract to the Department of Energy has produced targets designed to understand complex ion beam and Z-pinch plasma physics. This poster focuses on the features of target designs that make them suitable for Z-pinch plasma physics applications. Precision diagnostic targets will prove critical in understanding the plasma physics model needed for future ion beam and Z-pinch design. Targets are designed to meet specific physics needs; in this case we have fabricated targets to maximize information about the end-on versus side-on X-ray emission and Z-pinch hohlraum development. In this poster we describe the fabrication and characterization techniques. We will include discussion of current targets under development as well as target fabrication capabilities.
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit (1995)

The cytoplasmic domains of integrin beta subunits are involved in bidirectional transmembrane signaling. We report that the cytoplasmic domain of the integrin beta 3 subunit undergoes limited proteolysis by calpain, an intracellular calcium-dependent protease. Calpain cleavage occurs during platelet aggregation induced by agonists such as thrombin. Five cleavage sites have been identified. Four of these sites (C-terminal to Thr741, Tyr747, Phe754, and Tyr759) are utilized in intact platelets and flank two NXXY motifs (Asn744-Pro-Leu-Tyr747 and Asn756-Ile-Thr-Tyr759). The fifth site (Ala735) is accessible to calpain after EDTA treatment of the alpha IIb beta 3 heterodimer. The NXXY motif is critical to the bidirectional signaling functions of beta 3 integrins and their association with the cytoskeleton. Thus, calpain cleavage of the beta 3 cytoplasmic domain may provide a means to regulate integrin signaling functions.
De Duitse Greiferin Helga Zweig. Een Joodse Jodenjaagster bij de Brusselse Sipo-SD (2020)

is een zeer gecompliceerd geval en hier schijnt mij veel Joodsche intrige in het spel. Het meisje is geheel gebroken en is vrijwel ontroostbaar. Daarbij komt dat de gevangenisdirectie een rustig en vertrouwelijk gesprek niet toestaat. Een zeer somber geval. Zij leest het haar gegeven evangelie. 1 Iedereen die een beetje vertrouwd is met de geschiedenis van de Jodenvervolging in Brussel kent ongetwijfeld de figuur van "le Gros Jacques" oftewel de Joodse verklikker van Poolse origine Icek Glogowski, die als collaborateur werkte voor de Sicherheitspolizei-Sicherheitsdienst (Sipo-SD) van Brussel, en daar bijzonder actief was in het aanwijzen, opsporen en aanhouden van mede-Joden 2 . Glogowski werkte vanaf september
Regulation of voltage-induced Ca<sup>2+</sup> release machinery by cell-cell fusion in skeletal myogenesis (2022)

One of the most dynamic processes during skeletal myogenesis is cell-cell fusion, which promotes skeletal myoblast to form a large multi-nucleated myofiber equipped with EC-coupling machinery. Recently discovered transmembrane protein Myomixer (Mymx) executes cell-cell fusion, although the physiological significance of Mymx-mediated fusion on myogenic cell differentiation remains largely unknown. The current study focuses on the intracellular Ca2+ signaling mechanism to understand the physiological importance of Mymx mediated cell fusion in regulating voltage-induced Ca2+release in the developing skeletal muscle cells. C2C12 cells were used as an in vitro myogenesis model of skeletal muscle cells. We investigated intracellular Ca2+ release upon electric field stimulation applied to differentiated Mymx-KO cells and Mymx-rescued cells. We found that the efficiency of Ca2+ response was dependent on the Mymx gene expression. Importantly, expression levels of MyoD and myogenin were almost unaltered by the gene rescue of Mymx, suggesting that the Mymx-dependent Ca2+ response is regulated independently of these transcription factors. In conclusion, we found a novel regulatory linkage between Mymx expression and the voltage-induced Ca2+ release essential for EC coupling.
Biaxially self‐reinforced high‐density polyethylene prepared by dynamic packing injection molding. I. Processing parameters and mechanical properties (2004)

Abstract Uniaxial oscillating stress field by dynamic packing injection molding (DPIM) is well established as a means of producing uniaxially self‐reinforced polyethylene and polypropylene. Here, the effects on the mechanical properties of high‐density polyethylene (HDPE) in both flow direction (MD) and transverse direction (TD) of packing modules and processing parameters in DPIM are described. Both biaxially and uniaxially self‐reinforced HDPE samples are obtained by uniaxial shear injection molding. The most remarkable biaxially self‐reinforced HDPE specimens show a 42% increase of the tensile strength in both MD and TD. The difference of stress–strain behavior and impact strength between MD and TD for the DPIM moldings indicates the asymmetry of microstructure in the two directions. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 1584–1590, 2004
Communication Through Jamming over a Slotted ALOHA Channel (2008)

This work derives bounds on the jamming capacity of a slotted ALOHA system. A system with n legitimate users, each with a Bernoulli arrival process is considered. Packets are temporarily stored at the corresponding user queues, and a slotted ALOHA strategy is used for packet transmissions over the shared channel. The scenario considered is that of a pair of illegitimate users that jam legitimate transmissions in order to communicate over the slotted ALOHA channel. Jamming leads to binary signaling between the illegitimate users, with packet collisions due to legitimate users treated as (multiplicative) noise in this channel. Further, the queueing dynamics at the legitimate users stochastically couples the jamming strategy used by the illegitimate users and the channel evolution. By considering various i.i.d. jamming strategies, achievable jamming rates over the slotted ALOHA channel are derived. Further, an upper bound on the jamming capacity over the class of all ergodic jamming policies is derived. These bounds are shown to be tight in the limit where the offered system load approaches unity.
Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki 'Fuyu') on Melanin Biosynthesis (2010)

We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
Enantioselective Organocatalytic Hydrophosphination of α,β‐Unsaturated Aldehydes (2007)

Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99 % ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700916_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Ternary, Tunable Polyelectrolyte Complex Fluids Driven by Complex Coacervation (2014)

Complex coacervation was achieved by combining poly(allylamine) (PAH) or branched poly(ethylenimine) (PEI) with poly(acrylic acid) (PAA) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA). We systematically investigated the effects of stoichiometry, salt concentration, and pH. Ternary coacervates formed over a broader range of stoichiometries compared to the base PAA/PDMAEMA system. An enhanced resistance to salt, that is, resistance to dissolution of the complex with added salt, was observed for ternary coacervates. PEI-containing systems showed a considerable difference in salt resistance at pH 6–8 due to the dramatic change in charge density. This change was interpreted in the context of a theoretical treatment that relies on the Voorn–Overbeek model for free energy. Coacervate stability and viscoelastic behavior were affected by stoichiometry, salt, and pH. Ternary coacervates maintain the characteristics and tunability of typical binary coacervates, but the choice of the third component is important, as it significantly affects the response and material properties.
Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of HDM-2 antagonist JNJ-26854165 in patients with advanced refractory solid tumors (2009)

3514 Background: JNJ-26854165 is a novel first-in-clinic oral Human Double Minute-2 (HDM-2) ubiquitin ligase antagonist. It increases the level of HDM-2 client proteins (e.g. p53) by inhibiting the association of HDM-2-client protein complex with the proteosome. Preclinical studies have demonstrated potent anti-proliferative and apoptosis-inducing activity of JNJ-26854165 in a broad range of p53 wild type and mutant tumor models. Methods: A 3+3 dose escalation study with the primary objectives to determine the adverse event (AE) profile, dose limiting toxicities (DLT) and maximum tolerated dose of JNJ-26854165 is ongoing. Secondary objectives include evaluation of PK and PD activity. Eligible patients have ECOG PS≤2 and adequate hematological, renal and hepatic function. JNJ-26854165 is administered orally once daily on a continuous schedule (21-day cycles). Sequential skin and tumor biopsies are taken, and evaluations for HDM-2, p53 and other pathway related markers are performed, including further molecular analyses for HDM-2 activity. Results: 37 pts have been treated at 9 dose levels (DL), 4–300 mg qd. AEs included nausea, vomiting, fatigue, anorexia, insomnia, electrolyte disturbances, liver function tests and creatinine elevations, and asymptomatic QTc prolongation, mostly grade 1–2. A DLT, grade 3 QTcF prolongation, was observed in one patient at DL 9. The patient was asymptomatic and the QTc prolongation recovered after treatment discontinuation. PK data showed dose-proportionality. After dosing at 300 mg, steady state Cmax and AUC0–24h were 2–3 μg/mL and ≈50 μg.h/mL, respectively, well exceeding the expected effective exposure modeled by preclinical studies. PD data showed engagement of the targeted pathway such as dose-dependent p53 upregulation in skin, upregulation of HDM-2 levels in tumors after treatment, and an increase in plasma MIC-1 levels. No objective responses have been observed so far. Conclusions: JNJ-26854165 was well tolerated at doses beyond the expected effective exposure modeled by preclinical studies. PD activity was observed at the 150–300 mg dose levels. The trial continues with cohort expansion at 300 mg. Updated results will be presented. [Table: see text]
Dynamic Shaping of Femtoliter Dew Droplets (2018)

Herein, we show that wetting properties such as giant wetting anisotropy and dynamic shaping can be observed when femtoliter (submicron scale) dew droplets are condensed on nanopatterned mildly hydrophilic surfaces. Large-scale, optically transparent, nanopatterned TiO<sub>2</sub> surfaces were fabricated by direct nanoimprinting lithography of sol-gel-derived films. Square, infinitely elongated, or circular droplets were obtained with square, line, or concentric patterns, respectively, and were visualized in situ during formation and recession using optical microscopy and environmental scanning electronic microscopy. We first describe how extremely elongated droplets could form on mildly hydrophilic surfaces, naturally contaminated in real environmental conditions. In this configuration, the dew droplet shape can be dynamically and reversibly varied by controlling the out-of-equilibrium conditions associated with condensation/evaporation kinetics. As an example of the application, we propose a "morphological" sensor that exploits the shape of the dew droplets as a transduction mode for detecting organic vapors in the outer atmosphere. Importantly, this study is underlining that environmentally stable, purely hydrophilic surfaces can be smartly engineered to induce wetting phenomena at very small scale never observed so far for hydrophobic or heterogeneous surfaces. Our versatile approach based on nanoimprinted, transparent sol-gel films could open great perspectives for the implementation of environmentally stable, mildly hydrophilic materials for "dew engineering" applications such as open microfluidics, fuming for fingerprints, vapor sensing, or water harvesting on glass windows, for instance.
MR imaging of Maffucci syndrome (1988)

MR imaging of Maffucci syndromeEC Unger, HB Kessler, MJ Kowalyshyn, RD Lackman and GT MoreaAudio Available | Share
Binuclear tantalum hydride complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinuclear tantalum hydride complexesPatricia A. Belmonte, Richard R. Schrock, and Cynthia S. DayCite this: J. Am. Chem. Soc. 1982, 104, 11, 3082–3089Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ja00375a023https://doi.org/10.1021/ja00375a023research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fabrication of Out-of-Plane Branching Mirrors on Polymer Channel Waveguide (1995)

Noncrystalline polymers are suitable as a low cost and high-power optical waveguide material because they have little optical damage. Optical waveguides with large core and high-A (LCHD) are effective for a high-power application, because of low power density and easy assembly. High optical power is necessary for driving an optical amplifier 1 or optical devices with nonlinear optical effects or light-to-heat conversion. 2 To couple these devices utilizing the waveguide, out-of-plane branching mirrors are useful (Fig. 1). These mirrors are also applicable to the coupling of optical fiber or OEIC chips 3 with the optical waveguide. A channel waveguide and the mirror are usually fabricated by different mask processes. 4 These complicated processes require precise mask alignment procedure. In this report, we propose a process of simultaneously fabricating out-of-plane branching mirrors and polymer channel waveguides from a slab structure by reactive ion etching (RIE).