gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of Highly Potent RXR‐Specific Retinoids: Use of a Cyclopropyl Group as a Double Bond Isostere. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stroke neuroprotection revisited: Intra-arterial verapamil is profoundly neuroprotective in experimental acute ischemic stroke (2015)

While clinical trials have now solidified the role of thrombectomy in emergent large vessel occlusive stroke, additional therapies are needed to optimize patient outcome. Using our previously described experimental ischemic stroke model for evaluating adjunctive intra-arterial drug therapy after vessel recanalization, we studied the potential neuroprotective effects of verapamil. A calcium channel blocker, verapamil is often infused intra-arterially by neurointerventionalists to treat cerebral vasospasm. Such a direct route of administration allows for both focused targeting of stroke-impacted brain tissue and minimizes potential systemic side effects. Intra-arterial administration of verapamil at a flow rate of 2.5 µl/min and injection volume of 10 µl immediately after middle cerebral artery recanalization in C57/Bl6 mice was shown to be profoundly neuroprotective as compared to intra-arterial vehicle-treated stroke controls. Specifically, we noted a significant (P ≤ 0.05) decrease in infarct volume, astrogliosis, and cellular apoptosis as well as a significant increase in neuronal survival and functional outcome over seven days. Furthermore, intra-arterial administration of verapamil was well tolerated with no hemorrhage, systemic side effects, or increased mortality. Thus, verapamil administered intra-arterially immediately following recanalization in experimental ischemic stroke is both safe and neuroprotective and merits further study as a potential therapeutic adjunct to thrombectomy.
EFFECT OF NITROGEN INCORPORATION ON ELECTRICAL PROPERTIES OF HIGH-K NANOMIXED HfxAlyOz FILM CAPACITORS GROWN ON RU METAL ELECTRODES BY ATOMIC LAYER DEPOSITION (2005)

ABSTRACT The HfxAlyOz nanomixed capacitors grown by atomic layer deposition were treated by N2-plasma to improve electrical properties. Especially, leakage current characteristics was studied as a function of rf power and treatment temperature. The dielectric constant of the films was not varied irrespective of an increase of rf power and treatment temperature. The leakage current densities of the films treated by N2-plasma were effectively influenced by the treatment temperature rather than rf power. The N2-plasma treatment at 300°C and 70 W exhibits the most effective influence on improvement of the leakage current characteristics. The dielectric constant, dielectric loss, and leakage current density at 2.0 V in 6 nm-thick Hf0.27Al0.24O0.49 nanomixed films treated by N2-plasma at 300°C and 70 W were approximately 16, 0.5%, and 2 × 10− 6 A/cm2, respectively.
A Novel Peptide Antagonist of the Human Growth Hormone Receptor (2021)

Abstract The human growth hormone (GH) secreted by the anterior pituitary, binds to its cognate growth hormone receptor (GHR) and regulates longitudinal growth, organ development, metabolism of carbohydrate, protein, and lipid, as well as disease states like diabetes and cancer. GH action has also found to be a critical determinant of human lifespan. Consequently, there is considerable interest around developing an inhibitor of the GH action. The first and only antagonist of the GHR - pegvisomant - was developed at our lab more than 20 years back and is currently an FDA approved prescription drug for treating acromegaly, a condition of GH excess. Here we present the design, development, and initial characterization of a novel peptide antagonist of the human GHR. The novel antagonist termed ‘S1H’ is a 16-amino-acid peptide designed as a direct sequence mimetic of a unique fragment of the site-1 binding helix of the human GH molecule. To this end we have characterized S1H with mass spectrometry, circular dichroism spectropolarimetry, and in vitro biological assays using human cell lines expressing GHR. S1H inhibited GH induced STAT5 phosphorylation, a hallmark of GH induced intracellular signaling, in a dose-dependent manner in multiple cell lines. Furthermore, using alanine scanning mutagenesis studies, we identified a strong correlation between the helical propensity and biological activity of S1H. Taken together, our results confirm that S1H is a novel GHR inhibitor with prospective applications in human disease conditions on one hand, and also is a valuable molecular tool to study the nature of human GH-GHR interactions. We currently continue to characterize S1H for binding kinetics and in vivo effects on suppressing GH action.
Design and analysis of a multipacket signature detection system (2007)

Worm epidemics in the last few years have shown that manual defences against worm epidemics are not practical. Recently, various automatic worm identification methods have been proposed to be deployed at high-speed network nodes to respond in time to fast infection rates of worms. Unfortunately, these methods can easily be evaded by fragmentation of the worm packets. The straightforward defragmentation method is not applicable for these high-speed nodes due to its high storage (memory) requirement. In this paper, this multipacket signature detection problem is addressed using a defragmentation-free, space-efficient solution. A new data structure – Prefix Bloom Filters (PBFs) – along with a new heuristic, called the Chain Heuristic (CH) is proposed to significantly reduce the storage requirement of the problem, so that multipacket signature detection becomes feasible for high-speed network nodes.
Phase transfer and characterization of poly(ε-caprolactone) and poly(L-lactide) microspheres (2000)

A method suitable for transfer of poly(epsilon-caprolactone) and poly(L-lactide) microspheres (synthesized by pseudoanionic dispersion polymerization of epsilon-caprolactone and L-lactide in heptane-1,4-dioxane mixed solvent) from heptane to water was developed. This method consists of treating the microspheres with KOH-ethanol in the presence of surfactants (nonionic Triton X-405, anionic sodium dodecyl sulfate (SDS), and zwitterionic ammonium sulfobetaine-2 (ASB)). Partial hydrolysis of polyesters results in the formation of hydroxyl and carboxyl groups in the surface layer of microspheres and enhances their stability in water-based media. Minimal concentrations of surfactants, needed to obtain stable suspensions of particles, were equal to 3 x 10(-2) and 6 x 10(-2), and 3 x 10(-2) mol l(-1) for Triton X-405. SDS, and ASB, respectively. In the case of poly(epsilon-caprolactone) microspheres, suspensions in water were stable for all three surfactants for pH values ranging from 3 to 11. Suspensions of poly(L-lactide) were stable in the same range of pH values only for ASB. Surface charge density determined by electrophoretic mobility varied for poly(epsilon-caprolactone) microspheres from 2.6 x 10(-7) to 8.9 x 10(-7) mol m(-2), for particles stabilized with Triton X-405 and ASB. respectively. In the case of poly(L-lactide) microspheres, surface charge density varied from 3.9 x 10(-7) (stabilizer: Triton X-405) to 7.4 x 10(-7) mol m(-2) (stabilizer: ASB). Carboxyl groups located in the surface layer of poly(L-lactide) microspheres were used for covalent immobilization of 6-aminoquinoline, a fluorophore with an amino group. Maximum surface concentration of immobilized 6-aminoquinoline was equal to 1.9 x 10(-6) mol m(-2). Poly(epsilon-caprolactone) microspheres transferred into water were loaded with ethyl salicylate. Loading up to 38% (w/w) was obtained.
Incidence of dementia in elderly Latin Americans: Results of the Maracaibo Aging Study (2017)

Among Maracaibo Aging Study participants younger than 65 years, the incidence of dementia was higher than that of US Whites. Among individuals older than 65 years, the incidence was comparable to the mean of previous incidence estimates for other populations worldwide.
A Novel Approach for Mitigation of RF Oscillator Pulling in a Polar Transmitter (2011)

A novel technique for mitigation of self interference in a highly integrated SoC transmitter is presented. The interference originates from the internal power amplifier (i.e., aggressor) that leads to injection pulling of the local RF oscillator (i.e., victim). The characteristic of injection pulling was found to be dependent on the AM signal applied to the power amplifier. A hypothesis describing the mechanism of injection pulling of the local oscillator is presented. A mathematical model is developed to study the characteristics of this self interference verified then by measurements. Based on this model, a digitally controlled delay circuit is proposed and implemented in a digital polar GSM/EDGE transmitter that makes the system less susceptible to injection pulling through automatic phase adjustment between the aggressor and the victim. Compliant EVM and spectrum performance is measured on SoC fabricated in 65-nm CMOS showing the effectiveness of the proposed solution.
Alkoxyamine-Mediated Radical Synthesis of Indolinones and Indolines (2003)

Thermolysis of alpha-alkoxyamino propionanilides produces indolinones, whereas thermal reaction of N-allylaniline derivatives with various Tordo-type alkoxyamines results in formation of indolines in the radical regime. [reaction: see text]
A review on hexacyanoferrate-based materials for energy storage and smart windows: challenges and perspectives (2017)

Well-known since the 18th century,<italic>hexacyanoferrate</italic>, or “<italic>Prussian blue</italic>”, is currently getting its “second life” as a promising material for Li-ion batteries and electrochromic devices.
Stacking with No Planarity? (2016)

This viewpoint describes the results obtained from matched molecular pair analyses and quantum mechanics calculations that show unsaturated rings found in drug-like molecules may be replaced with their saturated counterparts without losing potency even if they are engaged in stacking interactions with the side chains of aromatic residues.
The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers (2010)

Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a propylsulfonamide-containing benzamide and was labeled with either carbon-11 or fluorine-18. [¹¹C]CMPyPB was synthesized by the alkylation of a 3-hydroxypyridine precursor using [¹¹C]MeI, and [¹⁸F]MK-6577 was synthesized by a nucleophilic aromatic substitution reaction using a 2-chloropyridine precursor. Each tracer shows good uptake into rhesus monkey brain with the expected distribution of highest uptake in the pons, thalamus, and cerebellum and lower uptake in the striatum and gray matter of the frontal cortex. In vivo blockade and chase studies of [¹⁸F]MK-6577 showed a large specific signal and reversible binding. In vitro autoradiographic studies with [¹⁸F]MK-6577 showed a large specific signal in both rhesus monkey and human brain slices and a distribution consistent with the in vivo results and those reported in the literature. In vivo metabolism studies in rhesus monkeys demonstrated that only more-polar metabolites are formed for each tracer. Of these two tracers, [¹⁸F]MK-6577 was more extensively characterized and is a promising clinical positron emission tomography tracer for imaging GlyT1 and for measuring GlyT1 occupancy of therapeutic compounds.
Transfer Hydrogenation of Aldehydes, Allylic Alcohols, Ketones, and Imines Using Molybdenum Cyclopentadienone Complexes (2018)

The molybdenum tetraphenylcyclopentadienone complex (C5Ph4O)Mo(CO)3(CH3CN) 1a is an effective precatalyst for the transfer hydrogenation of aldehydes, allylic alcohols, ketones, and imines under mild conditions with either 2-propanol or formic acid as reducing reagent. Mechanistic studies suggest that these molybdenum cyclopentadienone complexes can be reduced to the corresponding hydroxycyclopentadienyl Mo hydrides. These complexes, by virtue of the hydroxyl group on the cyclopentadienyl ligand, are more reactive and chemoselective than the analogous cyclopentadienyl molybdenum complexes for the reduction of ketones, aldehydes, and imines.
A system-level synthesis approach from formal application models to generic bus-based MPSoCs (2010)

System-level synthesis is the task of automatically implementing application models as hardware/software systems. It encompasses four basic sub tasks, namely decision making and refinement for both computation and communication. In the past, several system-level synthesis approaches have been proposed. However, it was shown that each of these approaches has drawbacks in at least one of the four sub tasks. In this paper, we present our efforts towards a comprehensive system-level synthesis by combining two academic system-level solutions into a seamless approach that automatically generates pin-accurate implementation-level models starting from a formal application model and generic MPSoC architecture templates. We analyze the system-level synthesis flow and define intermediate representations in terms of transaction level models that serve as link between existing tools. Furthermore, we present the automated transformation between models for combining two design flows. We demonstrate the combined flow on an industrial-strength example and show the benefits of fully automatic exploration and synthesis for rapid and early system-level design.
9 ppm NOx/CO Combustion System for “F” Class Industrial Gas Turbines (2001)

The Dry Low NOx (DLN) -2.6 combustion system has achieved emission rates of lower than 9 ppm NOx (dry, corrected to 15 percent O2) and CO from 50 to 100 percent load for the GE MS7001FA industrial gas turbine on natural gas. The system uses lean premixed combustion with fuel staging for low load stability. The first unit achieved commercial operation in March of 1996 with a firing temperature of 2350°F. As of September 9, 1999, it has accumulated over 11,800 hours of operation in peaking and base load service. Sixteen more units have since entered commercial service. Emissions data are shown for operation on natural gas. The DLN-2.6 system can operate on liquid fuel with water injection for NOx abatement. Power augmentation with steam injection is allowable while operating on natural gas. The premixed gas nozzles utilize swirl for flame stabilization. Aerodynamically shaped natural gas injectors are applied for flashback or flame-holding resistance.
Preparation and Characterization of Nitrogen and Oxygen Containing Graphite-like Pyropolymers from 5-(2-Pyridyl)-2,4-pentadiyn-1-ol (1997)

5-(2-Pyridyl)-2,4-pentadiyn-1-ol was polymerized over NbCl5- or TaCl5-based catalysts followed by pyrolysis to obtain graphite-like pyropolymers. The black metathesis polymer, poly[5-(2-pyridyl)-2,4-pentadiyn-1-ol], has the structure of a fully conjugated backbone and was converted into a polyacene-based polymer having pyridyl pendant groups. The pyropolymers prepared by vacuum pyrolysis over 700 °C have nitrogen atoms incorporated into graphene sheets. The polymers were characterized by elemental analysis, TGA, FT-IR, laser Raman, NMR, XPS, X-ray diffraction, temperature-programmed desorption experiments, charge/discharge experiments, and SEM and TEM studies.
Development of HPLC Method for Ixabepilone (Oncology Drug) in Bulk and Dosage Form: Quantification of Impurities and Forced Degradation Studies (2023)

The objective of study is to develop a new stability-indicating HPLC method for quantifying ixabepilone degradation products and known process impurities (EPO-2 and Epothilone B) in bulk and injectable dose forms. A gradient stability-indicating RP-HPLC approach was developed to determine the known impurities of ixabepilone in ixabepilone API and ixabepilone for injection. Ixabepilone was subjected to base, acid, oxidation, photolytic and thermal degradations. The gradient approach was used to optimize the mobile phase-A [pH 4.8 acetate buffer (10 mM) and acetonitrile 90:10 v/v] and mobile phase-B [pH 4.8 acetate buffer (10 mM) and acetonitrile 20:80 v/v] of a USP L1 column. A wavelength of 250 nm was chosen based on known impurities and degradation products response, with a 1.0 mL/min flow rate. In compliance with ICH criteria Q2(R1), the developed technique was validated. The stability-indicating-related impurities technique was proven to be appropriate for estimating degrading impurities and known impurities in ixabepilone API and ixabepilone injection.
Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells (1998)

Human peripheral blood mononuclear cells (PBMC) were stimulated with three nonpathogenic Lactobacillus strains and with one pathogenic Streptococcus pyogenes strain, and cytokine gene expression and protein production were analyzed. All bacteria strongly induced interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha mRNA expression and protein production. S. pyogenes was the most potent inducer of secretion of IL-12 and gamma interferon (IFN-gamma), and two of three Lactobacillus strains induced IL-12 and IFN-gamma production. All strains induced IL-18 protein production. IL-10 and IL-4 production was induced weakly and not at all, respectively. Our data show that nonpathogenic lactobacilli and pathogenic streptococci can induce Th1 type cytokines IL-12, IL-18, and IFN-gamma in human PBMC.
When and Why does a Model Fail? A Human-in-the-loop Error Detection Framework for Sentiment Analysis (2021)

Although deep neural networks have been widely employed and proven effective in sentiment analysis tasks, it remains challenging for model developers to assess their models for erroneous predictions that might exist prior to deployment. Once deployed, emergent errors can be hard to identify in prediction run-time and impossible to trace back to their sources. To address such gaps, in this paper we propose an error detection framework for sentiment analysis based on explainable features. We perform global-level feature validation with human-in-the-loop assessment, followed by an integration of global and local-level feature contribution analysis. Experimental results show that, given limited human-in-the-loop intervention, our method is able to identify erroneous model predictions on unseen data with high precision.
GPU-Assisted Learning on an Autonomous Marine Robot for Vision-Based Navigation and Image Understanding (2018)

We present a GPU-based integrated robotic platform that enables collision avoidance, navigation, and image understanding on a single underwater vehicle. The platform enables observational tasks such as coral reef health assessment by enabling simultaneous operation of multiple image analysis taskswhile navigating in close proximity to obstacles. The integration of a GPU allows us to leverage deep neural networks for collision avoidance and automated object detection and classification while a general purpose CPU processes images to perform visual Simultaneous Localization and Mapping (SLAM). In this paper, we describe the system architecture and summarize experimental results for coral detection and collision-free navigation.
Dynamic host configuration for managing mobility between public and private networks (2001)

The usage and service options of a pubic network generally differ from a private (enterprise or home) network and consequently, the two networks are often configured differently. The existence of both types of networks motivates our need to improve support and management of nomadic users who frequently roam between them. We describe a solution that allows client devices to configure themselves dynamically to adapt to the local network configuration. In addition to supporting mobility, we describe how our solution also provides fail-over mechanisms for providing highly available service, load balancing, and location services. Furthermore, our solution can be used to scale networks that are deployed in a large setting. We discuss in detail the various issues that need to be dealt with for achieving true device-level mobility, pointing out several unsolved problems in this area. The algorithms and software proposed in this paper have been implemented, are deployed, and are currently being used in a real-world public network that is operational at the Crossroads Mall in Bellevue, Washington.
Abstract 5032: New insights of miR-221 and miR-222 cluster functions in Burkitt lymphoma. (2012)

Abstract Burkitt lymphoma (BL) is a mature aggressive B-cell neoplasm, with a characteristic clinical presentation, morphology and immunophenotype. Several studies have indicated the importance of miRNAs in B cell maturation and in the development of B cell lymphomas. MicroRNAs (miRNA) are a class of naturally occurring, small, non-coding RNA that can control gene expression by targeting mRNA molecules for translational repression or cleavage. They are usually expressed in a tissue-specific manner and play important roles in apoptosis, differentiation and cell proliferation; therefore their deregulation may be involved in carcinogenesis or tumor progression by altering normal gene expression patterns. Over the past years microRNAs signatures have been described to characterize and classify different types of BL or to investigate the expression of miRNAs possibly regulated by c-Myc in BL cases positive or negative for Myc traslocation. Howhever, it remained unclear the functional role of miRNAs that have been found differentially expressed and no further studies have been conducted. We performed miRNA expression profile to gain further insights into the molecular pathology of BL. We conducted array analysis on a set of 5 sporadic BL patients, 3 endemic BL patients, 9 reactive tissues and 11 cases of mononucleosis. A common trend of miRNAs altered expression was also observed by NanoString analysis in 10 BL cell lines compared to 5 normal CD-19+ B cells. Among several miRNAs previously described be deregulated in BL we identified a severe down-regulation of miR-221, miR-222 in all classes of comparisons we analyzed. The down-regulation of miR-221 and miR-222 associated to BL has been also confirmed by q-RT-PCR method in a different cohort of BL patients (20) compared to the healthy controls (6). When miR-221 and miR-222 expressions have been restored in BL cancer cell lines, lacking of their expression, by gene expression profile we identified the differentially expression of several genes involved in ncRNAs processing, ncRNA metabolic process and also in the regulation of cell differentiation and cell cycle. Furthermore, functional experiments identified many of these genes as new direct targets of miR-221 and miR-222. In conclusion, our study reveals new insights into the functional significance in loss of miR-221 and miR-222 expression in BL pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5032. doi:1538-7445.AM2012-5032