gebhart/patrepeval huggingface dataset:
Interaction of Radiolabeled Antibodies with Fungal Cells and Components of the Immune System In Vitro and during Radioimmunotherapy for Experimental Fungal Infection (2006)

The present results suggest that the antimicrobial efficacy of RIT involves killing through promotion of fungal cell apoptosis-like death, reduction in yeast capsule size, cooperation with macrophages, and modulation of the inflammatory response.
A low Loss and Steerable Reflect Array Antenna in Ka Band (2004)

International audience
Observation of tW production in the single-lepton channel in pp collisions at $$ \sqrt{s} $$ = 13 TeV (2021)

A bstract A measurement of the cross section of the associated production of a single top quark and a W boson in final states with a muon or electron and jets in proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV is presented. The data correspond to an integrated luminosity of 36 fb − 1 collected with the CMS detector at the CERN LHC in 2016. A boosted decision tree is used to separate the tW signal from the dominant t $$ \overline{\mathrm{t}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> background, whilst the subleading W+jets and multijet backgrounds are constrained using data-based estimates. This result is the first observation of the tW process in final states containing a muon or electron and jets, with a significance exceeding 5 standard deviations. The cross section is determined to be 89 ± 4 (stat) ± 12 (syst) pb, consistent with the standard model.
Unravelling the Nature of Gold Surface Sites by Combining IR Spectroscopy and DFT Calculations. Implications in Catalysis (2009)

A combination of XPS, IR spectroscopy of adsorbed CO, and DFT calculations has allowed us to identify different gold sites on Au/TiO2 catalysts, and to analyze the electronic and structural changes induced on the supported gold nanoparticles when adsorbing CO. The characteristics of low coordinated neutral Au0, slightly positively charged Auδ+, and cationic AuIII species have been studied, and the IR bands associated with CO adsorbed on these species have been determined. The shift in the νCO frequency not only depends on the charge on the particle or on the particular gold atom to which CO binds but also on the degree of coordination of gold atoms, that is, particle shape, and the capability of CO to modify this particle shape. It has been unequivocally shown by combining IR/DFT results and H/D isotopic exchange experiments that, among the different gold species identified, only the low coordinated neutral gold atoms not involved in Au−O−Ti linkages are responsible for H2 dissociation on Au/TiO2 catalysts.
A new double epitaxial layer dielectric isolation technology for HVICs (2002)

A novel double epitaxial layer dielectric isolation (DELDI) technology suitable for high-voltage integrated circuits (HVICs) is presented. The application of the reduced surface field (RESURF) concept to enhance the breakdown voltage of a lateral double-diffused MOS (LDMOS) structure employing the DELDI technology is studied in detail. The breakdown voltage behavior of a DELDI structure is similar to that of an equivalent junction-isolated structure. The performances of various lateral power MOS controlled devices such as the LDMOS and lateral insulated gate bipolar transistors employing the DELDI technology are compared with those of their counterparts employing the conventional single layer DI technology. The performance of a lateral-emitter-switched thyristor structure using both technologies is examined. The performance of a new lateral-transistor-controlled thyristor is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Preparation of dehydrated powder of hemoglobin vesicles (1992)

Abstract The carbonyl hemoglobin (CO‐Hb), which was used to prevent denaturation (metHb) during the preparation of samples, was encapsulated into lipid vesicles constituted from unsaturated phospholipid, cholesterol and unsaturated fatty acid. Unsaturated components were polymerized by γ‐irradiation to enhance the stability of bilayer membrane. An aqueous dispersion of resulting Hb vesicles was freeze‐dried in the presence of saccharides (50–200 mM) to obtain a dehydrated powder of Hb vesicles. Change in the vesicle size, the leakage of encapsulated Hb and the oxidation of Hb to metHb were not observed. Therefore, the long‐term storage of Hb vesicles can be realized as a dry powder.
Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads (2022)

Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped reduce infection rates and thus prevent transmission of both infections. However, success depends on high population coverage that is maintained for the duration of the adult worm's lifespan. Given that these filarial worms can live up to 14 years in their human hosts, a macrofilaricidal drug would vastly accelerate elimination efforts. Here, we have evaluated the repurposed drug pyrvinium pamoate as well as newly synthesized analogs of pyrvinium for their efficacy against filarial worms in vitro and in vivo. We found that pyrvinium pamoate, tetrahydropyrvinium and one of the analogs were highly potent in inhibiting worms in in vitro whole-worm screening assays, and that all three compounds reduced female worm fecundity and inhibited embryogenesis in the <i>Brugia pahangi</i>-gerbil in vivo model of infection.
Determination of the maximum investment in a capital project (1995)

The sensitivity of investment NPV (net present value) to the discount rate is widely known. However, no current finance or real estate textbook investigates the sensitivity of NPV to the net investment outlay, or the installed purchase price of the asset. Such information can be critical, particularly in situations in which the investment is to be acquired by bidding against other interested parties. The maximum investment, even assuming certainty in the estimates of cash flows, and so on, is complicated by a dependence of the depreciation on the investment in the project and the applicable tax laws. This paper offers a solution to the problem of calculating an estimate for the maximum price that can be paid for a capital investment and still achieve a positive NPV.
Effect of image reconstruction bias upon spectroscopy-based quantification of chromophorcs in near-infrared tomography (2004)

Accuracy of chromophore concentrations in near-infrared tomography is affected by negative bias in the recovery of absorption coefficients and availability of limited wavelengths. The effect of these factors has been studied with suitable error models.
Surface and interface structure of epitaxial CoSi2 films on Si(111) (1991)

The surface and interface structures of molecular beam epitaxially grown CoSi2 films on Si(111) have been studied by scanning tunneling microscopy and by transmission electron microscopy, respectively. All surfaces are found to be inhomogeneous, exhibiting (2×1) and (2×2) reconstructed domains along with unreconstructed areas, depending on their stoichiometry. All of them could be imaged with atomic resolution. The surface step structure and the formation of pinholes have been examined for a wide range of growth conditions. Evidence is presented for micron-scale surface diffusion of Si on CoSi2 at temperatures as low as 800 K. The interface step structure, studied by transmission electron microscopy, has been found to depend critically on the details of the growth procedure.
Experimental and Theoretical Study of CO2 Insertion into Ruthenium Hydride Complexes (2016)

The ruthenium hydride [RuH(CNN)(dppb)] (1; CNN = 2-aminomethyl-6-tolylpyridine, dppb = 1,4-bis(diphenylphosphino)butane) reacts rapidly and irreversibly with CO2 under ambient conditions to yield the corresponding Ru formate complex 2. In contrast, the Ru hydride 1 reacts with acetone reversibly to generate the Ru isopropoxide, with the reaction free energy ΔG°(298 K) = -3.1 kcal/mol measured by (1)H NMR in tetrahydrofuran-d8. Density functional theory (DFT), calibrated to the experimentally measured free energies of ketone insertion, was used to evaluate and compare the mechanism and energetics of insertion of acetone and CO2 into the Ru-hydride bond of 1. The calculated reaction coordinate for acetone insertion involves a stepwise outer-sphere dihydrogen transfer to acetone via hydride transfer from the metal and proton transfer from the N-H group on the CNN ligand. In contrast, the lowest energy pathway calculated for CO2 insertion proceeds by an initial Ru-H hydride transfer to CO2 followed by rotation of the resulting N-H-stabilized formate to a Ru-O-bound formate. DFT calculations were used to evaluate the influence of the ancillary ligands on the thermodynamics of CO2 insertion, revealing that increasing the π acidity of the ligand cis to the hydride ligand and increasing the σ basicity of the ligand trans to it decreases the free energy of CO2 insertion, providing a strategy for the design of metal hydride systems capable of reversible, ergoneutral interconversion of CO2 and formate.
Synergistic Tumor Suppression by Coexpression of FHIT and p53 Coincides with FHIT-Mediated MDM2 Inactivation and p53 Stabilization in Human Non-Small Cell Lung Cancer Cells (2004)

Aberrations of the tumor suppressor genes FHIT and p53 are frequently associated with a wide range of human cancers, including lung cancer. We studied the combined effects of FHIT and p53 proteins on tumor cell proliferation and apoptosis in human non-small cell lung carcinoma (NSCLC) cells in vitro and on tumor growth in animal models by adenoviral vector-mediated cotransfer of wild-type FHIT and p53 genes. We found that the coexpression of FHIT and p53 synergistically inhibited tumor cell proliferation in NSCLC cells in vitro and suppressed the growth of human tumor xenografts in nude mice. Furthermore, we found that this synergistic inhibition of tumor cell growth corresponded with the FHIT-mediated inactivation of MDM2, which thereby blocked the association of MDM2 with p53, thus stabilizing the p53 protein. Our results therefore reveal a novel molecular mechanism consisting of FHIT-mediated tumor suppression and the interaction of FHIT with other cellular components in the pathways regulating p53 activity. These findings show that combination treatment with synergistic tumor-suppressing gene therapy such as Ad-FHIT and Ad-p53 may be an effective therapeutic strategy for NSCLC and other cancers.
Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells (2023)

Supplementary Figure 6 from Cancer Immunotherapy Based on Killing of &lt;i&gt;Salmonella&lt;/i&gt;-Infected Tumor Cells
A Compact Circuit Model for Si-Ge Avalanche Photodiodes over a Wide Range of Gain (2019)

A Si-Ge avalanche photodiode circuit model is demonstrated, which includes carrier transit time, avalanche buildup time, and electrical parasitics. Electrical and optical dynamics are accurately captured over a wide range of gain. Excellent matching between simulated and measured 50 Gb/s PAM4 eye diagrams is achieved.
Longitudinal medium vibrations in dielectrics excited by ultrashort optical pulses (2003)

Summary form only given. We show in the present paper that the propagation of TM polarized ultrashort pulses in a two dimensional geometry, even though detuned very far from its resonance for transverse fields, shows the possibility of resonant matter-field interaction. Namely, the interaction of longitudinal fields with longitudinal medium vibrations. As we expect the longitudinal fields to be also present in three dimensional pulse propagation, our two dimensional investigation of the TM polarized pulses serves as a paradigm for an additional mechanism with the potential to modify the critical self-focusing of intense ultrashort pulses.
Multi-flick: an evaluation of flick-based scrolling techniques for pen interfaces (2008)

Multi-flick, which consists of repeated flick actions, has received media attention as an intuitive and natural docu-ment-scrolling technique for stylus based systems. In this paper we put multi-flick to test, by designing several flick-based scrolling techniques. We map out the design space of multi-flick and identify mapping functions that make multi-flick a natural and intuitive technique for document naviga-tion. We then compare several multi-flick variations for navigating lists on three different devices – a PDA, a ta-bletPC, and a large table. Our study shows that compound-multi-flick (CMF) is the most preferred technique and it is at least as fast, if not faster than the traditional scrollbar. In a follow-up study, we evaluate multi-flick for scrolling text-based documents. Results show that all implementa-tions of multi-flick are as good as the scrollbar for short distances while CMF is the most preferred. We discuss the implications of our findings and present several design guidelines. ACM Classification: H5.2 [Information interfaces and presen-
Effects of Discontinuous Fiber Reinforcement on the Mechanical and Thermomechanical Properties of a Shape Memory Polymer (2007)

Over the last few years, we have developed shape memory polymers (SMPs) with several properties suitable for use in minimally-invasive biomedical devices. These properties include biocompatibility, the ability to fully recover large strains, the potential to serve as medication reservoirs for drug delivery, and low production cost. We and others have proposed use of shape memory polymers for various applications including cardiovascular stents, an endovascular clot removal system, and a self-tying suture.
Special Session: Countering IP Security threats in Supply chain (2019)

The continuing decrease in feature size of integrated circuits, and the increase of the complexity and cost of design and fabrication has led to outsourcing the design and fabrication of integrated circuits to third parties across the globe, and in turn has introduced several security vulnerabilities. The adversaries in the supply chain can pirate integrated circuits, overproduce these circuits, perform reverse engineering, and/or insert hardware Trojans in these circuits. Developing countermeasures against such security threats is highly crucial. Accordingly, this paper first develops a learning-based trust verification framework to detect hardware Trojans. To tackle Trojan insertion, IP piracy and overproduction, logic locking schemes and in particular stripped functionality logic locking is discussed and its resiliency against the state-of-the-art attacks is investigated.
Mobile Data explosion and planning of heterogeneous networks (2012)

With the continuous increase in Mobile Data traffic, limited availability of wireless spectrum and increased pressure on unit costs, operators have been looking at heterogeneous network architectures as an opportunity to solve the capacity and cost issues of mobile networks. In this paper, we will address the expected growth in traffic, and how the use of a combination of macro, small 3G/4G cells and carrier-grade WiFi access points can provide an optimized architecture to handle the services and resulting traffic. The paper will also address the issues that need to be resolved to fully leverage the potential of heterogeneous networks including interference management, geo-location of hotspots, low cost backhaul for small cells, and deployment cost.
Contact stress assessment of conventional and highly crosslinked ultra high molecular weight polyethylene acetabular liners with finite element analysis and pressure sensitive film (2006)

Stress magnitude and distribution of both conventional polyethylene versus a crosslinked polyethylene in the liner of a total hip replacement (THR) were examined using finite element analysis and pressure sensitive film. Both types of polyethylene were assessed against head sizes of 22 and 28 mm with 5-mm thick polyethylene liners and head sizes of 28, 38, and 46 mm with 3-mm thick polyethylene liners. Liners with 5-mm conventional polyethylene represented successful combinations with long track records. Our hypothesis was that although the combination of the large head and the lower modulus of the highly crosslinked polyethylene would lead to lower stresses, the stresses would be excessive if the liner was extremely thin at 3 mm. Von Mises stresses at the articulating surface of the highly crosslinked liners were lower, when compared to conventional polyethylene, in every THR size examined. Specifically, however, the 38- and 46-mm inner diameter (ID) highly crosslinked polyethylene even at the extreme of only 3-mm thick had lower stresses than the 22-mm ID conventional liner of 5-mm thickness. These data indicate that the use of a large head against highly crosslinked material even at 3-mm thickness results in lower stresses than in an existing conventional 22-mm head and 5-mm thick combination. Obviously, other considerations will influence the minimum thickness to be recommended.
Efficient and versatile synthesis of dipeptide isosteres containing .gamma.- or .delta.-lactams (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient and versatile synthesis of dipeptide isosteres containing .gamma.- or .delta.-lactamsThomas M. Zydowsky, Joseph F. Dellaria Jr., and Hugh N. NellansCite this: J. Org. Chem. 1988, 53, 24, 5607–5616Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/jo00259a003https://doi.org/10.1021/jo00259a003research-articleACS PublicationsRequest reuse permissionsArticle Views540Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Real-time decentralized control with CAN (2002)

This paper deals with two important concerns in decentralized control: (1) communication over field bus and (2) the transition from a single powerful, centralized controller to many smaller, distributed controllers. The former requires real-time network scheduling for the field bus to ensure that messages get delivered in a timely manner, while the latter requires a low-overhead real-time operating system to cater to the specific needs of distributed control. We present solutions to both of these problems in the form of a network scheduling scheme for the controller area network (CAN) field bus and the EMERALDS real-time operating system which we have designed with the needs of the decentralized control application designer in mind.
Transcriptional control in Alicyclobacillus acidocaldarius and associated genes, proteins, and methods (2023)

Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription or transcription or transcriptional control using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.
Sufficient Tissue Engineered Heart Valves: A Question of Cell Source? (2012)

Abstract A promising approach to solve the problems of currently used heart valve prostheses, e.g. degeneration, need for anticoagulation and risk of endocarditis, is the tissue engineering of heart valves. By using patient derived cells and fibrin as a scaffold for these valves we aim at completely autologous heart valves which have the potential to grow and hence are especially interesting for valve replacement in paediatric surgery. However, a major obstacle on the way to clinical application of tissue engineered heart valves (TEHV) is the cell-mediated tissue contraction which leads to the shrinkage of the valve’s leaflets and thus to its insufficiency. Several groups tested TEHV in the pulmonary position in the sheep model and reported mild to moderate regurgitation already at a short postimplantation time. Our goal was to analyse the influence of the cell source on the sufficiency of TEHV. Different cell sources, among which ovine carotid artery (OCA) and umbilical artery (OUA), were compared on their contractility and contraction of fibrin gels in which the cells were embedded. Cell phenotype was characterized by immunostaining of α-smooth muscle actin (α-SMA) and myosin light-chain kinase (MLCK) as markers for cell contractile activity. For the gel contraction assay, fibrin gels with a cell concentration of 5 × 10^6/ml were moulded in a 24-well plate (n ≥ 3) and their retraction was evaluated over 15 days by measuring the gels' area in relation to their original area. Hydroxyproline content, cell proliferation and burst strength were also determined. Ovine carotid artery cells exhibited a highly contractile myofibroblast phenotype (high α-SMA and MLCK expression), while OUA cells were mostly non-contractile fibroblasts with only few cells expressing α-SMA and MLCK. After 15 days, OCA embedded gels were contracted to 30.6 ± 2.0% of the original size while OUA gels maintained a size of 83.2 ± 3.7% of the initial area. To directly correlate cell contractility and valve sufficiency we moulded fibrin based heart valves using OUA and OCA cells. All valves were conditioned statically for 14 days in the closed-leaflet configuration and successively dynamically in the open-leaflet configuration in bioreactors for 30 days. While the leaflets of TEHV with OCA cells contracted and led to insufficient valves at the end of the conditioning protocol, we were able to produce completely sufficient heart valves after in vitro conditioning using non-contractile OUA cells. In an on-going animal study OUA embedded TEHV, after being seeded with endothelial cells, are implanted in the pulmonary artery in lambs to analyse their growth potential and their hemodynamic performance in vivo. Transesophageal echocardiography showed both in colour Doppler and in cw Doppler mode that after fourteen weeks a first implanted valve was still completely sufficient and showed no sign of cell-mediated tissue contraction.
Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy (2016)

Abstract We present a collection of Galaxy tools representing many popular algorithms for detecting somatic genetic alterations from cancer genome and exome data. We implemented methods for parallelization of these tools within Galaxy to accelerate runtime and have demonstrated their usability on cloud-based infrastructure and commodity hardware. Some tools represents extensions or refinement of existing toolkits to yield visualizations suited to cohort-wide cancer genomic analysis. For example, we present Oncocircos and Oncoprintplus, which generate data-rich summaries of exome-derived somatic mutation. Workflows that integrate several of these to perform some standard data integration and visualization tasks are demonstrated on a cohort of 96 diffuse large B-cell lymphomas, enabling the discovery of multiple candidate lymphoma-related genes that have not been reported previously.