gebhart/patrepeval huggingface dataset:
Carrier Phase Recovery without Pilot Symbols for Non-Differential Coherent Receivers (2016)

We propose a time-domain hybrid modulation technique to eliminate the cycle-slip problem in non-differential coherent receivers. The method avoids the use of pilot symbols for carrier phase recovery, achieving 0.8 dB gain over differential modulation.
Basic relationship between multipath angularspread and narrowband fading in wireless channels (1998)

A novel relationship between the azimuthal distribution of multipath power and narrowband small-scale fading characteristics is developed. The fundamental relationship is useful for studying adaptive arrays, smart antennas, equalisation, diversity, and any other wireless technology or concept that depends on the spatial characteristics of radiowave and microwave propagation.
Model-driven Per-panel Solar Anomaly Detection for Residential Arrays (2021)

There has been significant growth in both utility-scale and residential-scale solar installations in recent years, driven by rapid technology improvements and falling prices. Unlike utility-scale solar farms that are professionally managed and maintained, smaller residential-scale installations often lack sensing and instrumentation for performance monitoring and fault detection. As a result, faults may go undetected for long periods of time, resulting in generation and revenue losses for the homeowner. In this article, we present SunDown, a sensorless approach designed to detect per-panel faults in residential solar arrays. SunDown does not require any new sensors for its fault detection and instead uses a model-driven approach that leverages correlations between the power produced by adjacent panels to detect deviations from expected behavior. SunDown can handle concurrent faults in multiple panels and perform anomaly classification to determine probable causes. Using two years of solar generation data from a real home and a manually generated dataset of multiple solar faults, we show that SunDown has a Mean Absolute Percentage Error of 2.98% when predicting per-panel output. Our results show that SunDown is able to detect and classify faults, including from snow cover, leaves and debris, and electrical failures with 99.13% accuracy, and can detect multiple concurrent faults with 97.2% accuracy.
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells (2011)

We recently demonstrated that human BM cells can be treated in vitro with defined growth factors to induce the rapid generation of myeloid-derived suppressor cells (MDSCs), hereafter defined as BM-MDSCs. Indeed, combination of G-CSF + GM-CSF led to the development of a heterogeneous mixture of immature myeloid cells ranging from myeloblasts to band cells that were able to suppress alloantigen- and mitogen-stimulated T lymphocytes. Here, we further investigate the mechanism of suppression and define the cell subset that is fully responsible for BM-MDSC-mediated immune suppression. This population, which displays the structure and markers of promyelocytes, is however distinct from physiologic promyelocytes that, instead, are devoid of immuosuppressive function. In addition, we demonstrate that promyelocyte-like cells proliferate in the presence of activated lymphocytes and that, when these cells exert suppressive activity, they do not differentiate but rather maintain their immature phenotype. Finally, we show that promyelocyte-like BM-MDSCs are equivalent to MDSCs present in the blood of patients with breast cancer and patients with colorectal cancer and that increased circulating levels of these immunosuppressive myeloid cells correlate with worse prognosis and radiographic progression.
Cu-Cu wafer bonding: An enabling technology for three-dimensional integration (2014)

Wafer-level hybrid bonding with Cu/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> is a very promising technique to fabricate three-dimensional integrated circuits, because it enables high performance operation with low power consumption as well as low 3D stacking costs. For a successful hybrid bonding process, the particular bonding properties of unstructured Cu-Cu and Si-SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> wafer bonding were investigated. For Cu-Cu bonding, the Cu oxide removal prior to bonding is one of the keys to success. The combination of ex-situ citric acid and in-situ forming gas pre-treatments before bonding resulted in sufficient bonding quality at low temperature as low as 200°C. In the case of plasma activated Si-direct wafer bonding, a bonding strength similar to the Si bulk fracture strength was achieved. So far, the isolated Si-direct and Cu-Cu thermo-compression wafer bonding processes were successfully demonstrated. Finally, crucial interdependencies, such as the plasma activation on Cu surfaces and the citric acid treatment on Si surfaces, for a successfully hybrid wafer bonding were presented.
ChemInform Abstract: Cyclophanes with Self‐Recognising Components. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Perspectives for Gene Therapy of Wilson Disease (2007)

Wilson disease is a rare autosomal-recessive copper overload disorder due to mutations of the Wilson disease gene ATP7B. The disease typically manifests at late childhood or in young adults with hepatic and/or neurological symptoms. Being fatal without medical treatment or liver transplantation the long-term outcome of Wilson disease depends on the adherence to an effective treatment. Because current medical treatment options are not effective in all Wilson disease patients and adherence to therapy is a problem, gene therapy might represent an alternative curative future therapy. In the rat model of Wilson disease adenoviral and lentiviral gene transfer studies could prove that viral gene transfer is therapeutically effective and can reverse clinical symptoms. However, both approaches were limited by a more or less transient transgene expression. As several tactics can be used to overcome these current limitations, gene therapy approaches may become more efficient than standard medical treatment for Wilson disease in the future. This review discusses both, existing vectors and strategies and prospective developments towards liver-directed gene therapy, although there is still a long way to go until gene therapy can be used for safe treatment of Wilson disease in humans.
Modular Continuous Flow Synthesis of Imatinib and Analogues (2019)

A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
Advances in efficient optical links to enhance desktop multimedia processor systems (1997)

Rapid progresses in computers, telecommunication, and consumer electronics research have stimulated the emergence of powerful multimedia systems that will have profound impacts, on scientific, industrial, business endeavors, and even our daily lives. Continuous advances in deep-submicron microelectronic fabrication technologies have made possible the integration of millions of transistors on a single silicon microchip. However, one of the anticipated major technological breakthroughs will be the efficient and reliable use of optical links to increase the communication bandwidth and quality of electronic systems. Optical links can be used not only at the machine-to-machine level, but also at the board-to-board and chip-to-chip levels. The architecture, design, and associated measurement results are presented regarding the use of optical interconnections to enhance desktop multimedia computing systems.
Run-to-Run Tuning of Model Predictive Control for Type 1 Diabetes Subjects: In Silico Trial (2009)

The ARX model identification procedure offers an automatic tool for patient model individualization. The run-to-run approach is an effective way to auto-tune the aggressiveness of the closed-loop control law, is robust to meal variation, and is also capable of adapting the regulator to slow parameter variations, e.g., on insulin sensitivity.
Keratin network modifications lead to the mechanical stiffening of the hair follicle fiber (2016)

The complex mechanical properties of biomaterials such as hair, horn, skin, or bone are determined by the architecture of the underlying fibrous bionetworks. Although much is known about the influence of the cytoskeleton on the mechanics of isolated cells, this has been less studied in tridimensional tissues. We used the hair follicle as a model to link changes in the keratin network composition and architecture to the mechanical properties of the nascent hair. We show using atomic force microscopy that the soft keratinocyte matrix at the base of the follicle stiffens by a factor of ∼360, from 30 kPa to 11 MPa along the first millimeter of the follicle. The early mechanical stiffening is concomitant to an increase in diameter of the keratin macrofibrils, their continuous compaction, and increasingly parallel orientation. The related stiffening of the material follows a power law, typical of the mechanics of nonthermal bending-dominated fiber networks. In addition, we used X-ray diffraction to monitor changes in the (supra)molecular organization within the keratin fibers. At later keratinization stages, the inner mechanical properties of the macrofibrils dominate the stiffening due to the progressive setting up of the cystine network. Our findings corroborate existing models on the sequence of biological and structural events during hair keratinization.
The tumor-specific antigens landscape in acute myeloid leukemia (2019)

In theory, tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but none have been identified in acute myeloid leukemia (AML) so far. We have recently designed a proteog-enomic approach allowing the identification of MHC class I-associated peptides deriving from any reading frame of all genomic regions (not only from exons). Using this approach, we could identify 82 TSAs from 18 primary human AML samples. All these TSAs derived from unmutated transcripts which were aberrantly expressed by allegedly non-coding regions of the genome (that would have been missed by conventional exome-based approaches). In agreement with previous reports showing that high intron retention is a key feature in AML, we found that introns were the main source of TSAs (54.8%). The TSAs were presented by 24 different HLA allotypes, together covering 98,04% of the world population. The examination of the expression of the RNAs coding for the TSAs showed that most of them (68%) were expressed by at least 50% of AML samples in the “The Cancer Genome Atlas” (TCGA) cohort while all of them were either expressed at very low levels or not expressed at all in normal tissues (from the “Genotype-Tissue Expression” (GTEx) project). We have yet to discover the specific epigenetic changes leading to TSA expression in cancer cells. Meanwhile, we propose that vaccination against ab-errantly expressed TSAs could be used to treat a vast majority of patients, with minimal risks of collateral damage to healthy normal tissues.
Infection of the Diaprepes Root Weevil, Diaprepes abbreviatus (Coleoptera: Curculionidae) by an Iridovirus (2001)

The Diaprepes root weevil (DRW), Diaprepes abbreviatus (L.), is now regarded as a principal threat to sustainability of the citrus industry in Florida. Since its introduction into Florida in 1964, the weevil has spread throughout the citrus producing areas of peninsular Florida. Adult females oviposit on leaves. Neonate larvae fall to the ground and burrow into the soil where they feed on progressively larger roots as the larvae grow. Tree
Identification of lignans by liquid chromatography‐electrospray ionization ion‐trap mass spectrometry (2007)

The fragmentation pattern of 30 compounds belonging to different classes of the lignan family was studied by liquid chromatography-electrospray ionization ion-trap mass spectrometry. On the basis of the observed fragmentation patterns, identification of different types of lignans was achieved. For example, dibenzylbutyrolactone lignans showed a characteristic fragmentation pathway by the loss of 44 Da (CO(2)) from the lactone moiety, whereas dibenzylbutanediols showed a loss of 48 Da by a combined loss of formaldehyde and water from the 1,4-butanediol moiety. Lignan glycosides readily lost the sugar residue to give the parent lignan as their primary product ion. In addition, several compound-specific fragmentations were observed and used for identification of individual compounds.A versatile method for analyses of lignans was developed using LC separation on a C8 column followed by fragmentation and detection of ions produced in the ion trap.
Video compression by mean-corrected motion compensation of partial quadtrees (1997)

This paper describes Iterated Systems' submission to the MPEG-4 committee in January 1996. A system for compressing video is presented which expresses predictive frames of a sequence by means of motion vectors applied to variable-size blocks with a constant intensity adjustment. The motion vectors are organized into a partial quadtree, which allows incomplete splitting of blocks into zero to four quadrants. The motion vectors, mean intensity offsets, and partial quadtree structure are arrived at by a joint optimization process which may be carried out in a bottom-up fashion. A form of generalized overlapped block motion compensation applicable at all block sizes is presented, and a method for encoding segmented video is shown. The performance of the algorithm is compared with that of Telenor's H.263 for three of the MPEG-4 test sequences which show that the former is comparable or superior to the latter for low bit rates.
Supplementary Figure 1 from Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example (2023)

&lt;p&gt;Radiation schedule for the cell culture and xenograft experiments. Human prostate cancer cells were either plated or injected subcutaneously into the flanks of the right hind legs of athymic nude mice. After 24 h (in vitro) or tumors reached a tumor size of 5 mm x 5 mm (in vivo), tumors were irradiated with different fractionation regimens including a single dose of 10 Gy at day 5, 10 fractions of 1 Gy (2 fractions per day), or 5 fractions of 2 Gy (1 fraction per day). Unirradiated cells or tumors were used as control.&lt;/p&gt;
Structure of Metal–Organic Framework Glasses by Ab Initio Molecular Dynamics (2020)

&lt;div&gt; &lt;div&gt; &lt;div&gt; &lt;p&gt;While metal–organic frameworks have been mostly studied in their crystalline form, recent advances have been made on their amorphous phases, both in fundamental understanding and in relation to possible applications. In particular, the zeolitic imidazolate (ZIF) glasses, that can be obtained from quenching liquid ZIFs, have shown promise. However, the details of their microscopic structure are very hard to probe experimentally. Here we use ab initio molecular dynamics simulations to investigate the nature of the ZIF glasses obtained from quenching molten ZIFs in silico. Through computational modeling of the melt–quench process on three different ZIF crystals, we aim to understand the effect of topology and chemistry upon the structure of the glass, compared to crystalline precursor and high temperature liquid. It is the first direct computational description of MOF glasses at the quantum chemical level. &lt;/p&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;
KCNQ1/KCNE1 K + channel and P2Y 4 receptor are co-expressed from the time of birth in the apical membrane of rat strial marginal cells (2007)

Chromanol 293B, a blocker of KCNQ1/KCNE1 K(+) channel, inhibited short-circuit currents (I ( sc )) from P1 to P21. Similarly, I ( sc ) were found to be decreased by uridine 5'-triphosphate at all ages. The antagonist profiles indicated that the apical P2Y receptor is P2Y(4) subtype. KCNQ1, KCNE1, and P2Y(4) were immunolocalized in the apical region of stria vascularis at P1.
PEF treatment of apples and the biochemical interactions for brown compounds formation (2013)

International audience
Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes (2015)

Controlling the relative and absolute configuration of octahedral metal complexes constitutes a key challenge that needs to be overcome in order to fully exploit the structural properties of octahedral metal complexes for applications in the fields of catalysis, materials sciences, and life sciences. Herein, we describe the application of a proline-based chiral tridentate ligand to decisively control the coordination mode of an octahedral rhodium(III) complex. We demonstrate the mirror-like relationship of synthesized enantiomers and differences between diastereomers. Further, we demonstrate, using the established pyridocarbazole pharmacophore ligand as part of the organometallic complexes, the importance of the relative and absolute stereochemistry at the metal toward chiral environments like protein kinases. Protein kinase profiling and inhibition data confirm that the proline-based enantiopure rhodium(III) complexes, despite having all of the same constitution, differ strongly in their selectivity properties despite their unmistakably mutual origin. Moreover, two exemplary compounds have been shown to induce different toxic effects in an ex vivo rat liver model.
Large-System Comparison of Space-Time Transmit Diversity and Orthogonal Transmit Diversity for Downlink W-CDMA (2006)

In this paper, we continue our study of the performance of W-CDMA transmit diversity (TD) that we started in B. Mouhouche et al. (2005). We compare the performance of two open-loop TD techniques for W-CDMA: The space time transmit diversity (STTD) and the orthogonal transmit diversity (OTD). We use the output SENR provided by a RAKE receiver when combined with each of these diversity techniques. It is impossible to obtain useful conclusions about the performance of the two techniques because the SENR depend in a complex way on many parameters like the spreading codes, the channel, etc. In order to obtain positive results, we follow the classical approach used for the first time in D.N.C. Tse and S. Hanly (1999) and assume that the spreading codes are random following a certain distribution. In this case, the SINRs can be interpreted as random variables. We consider the limit of the these SENRs when the spreading factor N and the number of users K tend to oo with fixed ratio. Under these conditions, the output SENRs can be shown to converge to deterministic limits independent of the "random" spreading codes. We interpret the output SENRs and discuss the different parameters influencing the performance of the two techniques
Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combination (2009)

Catheters coated with the triclosan + DspB combination showed synergistic, broad-spectrum and durable antimicrobial activity. Furthermore, the in vivo efficacy of catheters coated with this unique antimicrobial/antibiofilm composition prompts clinical evaluation of such an innovative approach.
Figure S5 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues (2023)

&lt;p&gt;Viability (evaluated after one doubling time) of PSMA-positive HUVEC in monolayers after treatment by targeted radiolabeled constructs.&lt;/p&gt;
Evaluated kinetic and photochemical data for atmospheric chemistry: Part 1 ? gas phase reactions of Ox, HOx, NOx and SOx species (2003)

International audience
Augmented Cognition Transition (2009)

Abstract : This report details the work done by Honeywell Aerospace Advanced Technology to address two key challenges in the transition of Augmented Cognition (AugCog) technology to the Army's Future Force: 1) integration of the Honeywell AugCog system into the Future Force Warrior (FFW) Soldier system and 2) deployment and evaluation of the dry electrodes for the collection of electroencephalogram (EEG) data under the helmet in an operational environment. Separate evaluations were conducted to test the success of both efforts. The Honeywell team successfully integrated and executed the AugCog hardware and software within the FFW Leader System Software during the U.S. Army's Command, Control, Communication, Computers, Intelligence, Surveillance, and Reconnaissance (C4ISR) 2007 on-the-Move (OTM) Event. The team then collected electrocardiogram (ECG) and EEG data on the third squad leader, during force-on-force exercises, of a signal quality sufficient to classify cognitive state classification in a harsh operational environment. Accordingly, encouraging results showed >80% classification of workload in the field with EEG alone, thereby advancing the deployability of EEG sensor systems. Together, these successes represent an advance in integration maturity of the AugCog system as it moves towards transition into the Army's future systems.
Directed Incremental Symbolic Execution (2014)

The last few years have seen a resurgence of interest in the use of symbolic execution—a program analysis technique developed more than three decades ago to analyze program execution paths. Scaling symbolic execution to real systems remains challenging despite recent algorithmic and technological advances. An effective approach to address scalability is to reduce the scope of the analysis. For example, in regression analysis, differences between two related program versions are used to guide the analysis. While such an approach is intuitive, finding efficient and precise ways to identify program differences, and characterize their impact on how the program executes has proved challenging in practice. In this article, we present Directed Incremental Symbolic Execution (DiSE), a novel technique for detecting and characterizing the impact of program changes to scale symbolic execution. The novelty of DiSE is to combine the efficiencies of static analysis techniques to compute program difference information with the precision of symbolic execution to explore program execution paths and generate path conditions affected by the differences. DiSE complements other reduction and bounding techniques for improving symbolic execution. Furthermore, DiSE does not require analysis results to be carried forward as the software evolves—only the source code for two related program versions is required. An experimental evaluation using our implementation of DiSE illustrates its effectiveness at detecting and characterizing the effects of program changes.