gebhart/patrepeval huggingface dataset:
Real-Time Huffman Encoder with Pipelined CAM-Based Data Path and Code-Word-Table Optimizer (2007)

This paper presents a novel optimized real-time Huffman encoder using a pipelined data path based on CAM technology and a parallel code-word-table optimizer. The exploitation of CAM technology enables fast parallel search of the code word table. At the same time, the code word table is optimized according to the frequency of received input symbols and is up-dated in real-time. Since these two functions work in parallel, the proposed architecture realizes fast parallel encoding and keeps a constantly high compression ratio. Evaluation results for the JPEG application show that the proposed architecture can achieve up to 28% smaller encoded picture sizes than the conventional architectures. The obtained encoding time can be reduced by 95% in comparison to a conventional SRAM-based architecture, which is suitable even for the latest end-user-devices requiring fast frame-rates. Furthermore, the proposed architecture provides the only encoder that can simultaneously realize small compressed data size and fast processing speed.
System power management support in the IBM POWER6 microprocessor (2007)

The IBM POWER6™ microprocessor chip supports advanced, dynamic power management solutions for managing not just the chip but the entire server. The design facilitates a programmable power management solution for greater flexibility and integration into system- and data-center-wide management solutions. The design of the POWER6 microprocessor provides real-time access to detailed and accurate information on power, temperature, and performance. Together, the sensing, actuation, and management support available in the POWER6 processor, known as the EnergyScale™ architecture, enables higher performance, greater energy efficiency, and new power management capabilities such as power and thermal capping and power savings with explicit performance control. This paper provides an overview of the innovative design of the POWER6 processor that enables these advanced, dynamic system power management solutions.
AI AS A MICROSERVICE (AIMS) OVER 5G NETWORKS (2018)

As data-driven decision-making services are being infused into Internet of Things (IoT) applications, especially at the 5G networks, Artificial Intelligence (AI) algorithms such as deep learning, reinforcement learning, etc. are being deployed as monolithic application services for autonomous decision processes based on data from IoT devices. However, for latency sensitive IoT applications such as health-monitoring or emergency-response applications, it is inefficient to transmit data to the Cloud data centers for storage and AI based processing. In this article, 5G integrated architecture for intelligent IoT based on the concepts of AI as a microservice (AIMS) is presented. The architecture has been conceived to support the design and development of AI microservices, which can be deployed on federated and integrated 5G networks slices to provide autonomous units of intelligence at the Edge of Things, as opposed to the current monolithic IoT-Cloud services. The proposed 5G based AI system is envisioned as a platform for effective deployment of scalable, robust, and intelligent cross-border IoT applications to provide improved quality of experience in scenarios where realtime processing, ultra-low latency and intelligence are key requirements. Finally, we highlight some challenges to give future research directions.
Flavin-oligonucleotide conjugates: sequence specific photocleavage of DNA (1998)

A flavin–oligonucleotide conjugate forms a stable triple helix with a double-stranded DNA sequence of HIV-1, and selectively photocleaves it at the 3′-G of a GG doublet located 7 bases away from the flavin position.
Target discrimination in the extended SWIR (eSWIR) band (2-2.5µm) compared to Vis, NIR, and SWIR in degraded visual environments (2022)

Long-range target identification is well studied in the Visible (Vis) and near-infrared (NIR) bands, and more recently in the shortwave infrared (SWIR). The longer wavelength of SWIR (1-1.7&mu;m) improves target detection for both long ranges and under challenging atmospheric conditions because it is less limited by scattering and absorption in the atmosphere. For these reasons, SWIR sensors are proliferating on military platforms. The extended shortwave infrared (eSWIR) band spanning from 2 to 2.5&mu;m is not typically limited by diffraction, and, as a result, the band benefits target acquisition both at long ranges and for degraded visual environments. Theoretical and experimental data compare eSWIR to Vis, NIR, and SWIR for atmospheric transmission, reflectivity, illumination, and sensor resolution and sensitivity. The experimental setup includes two testbeds, each with four cameras. The first is a wide field of view (FOV) testbed matching FOV at 20 degrees for each camera. The second is a narrow FOV telescope testbed to match instantaneous FOV (IFOV) for consistent resolution across all four bands at long ranges. Both the theory and experiment demonstrate advantages of using eSWIR for long-range target identification under degraded visual environments.
Formation of a tetrahedral WC3 framework from a cyclic WC3(tungstenacyclobutadiene) system via attack on tungsten by nitrogen-doner ligands: X-ray study of W[C3Me2(But)][Me2N(CH2)2NMe2]Cl3 (1984)

The tungstenacyclobutadiene complex W[C3Me2(But)]Cl3 reacts with Me2N(CH2)2 NMe2 to form the 1:1 adduct W[C3Me2(But)][Me2N(CH2)2 NMe2]Cl3; a single-crystal X-ray diffraction study of this product shows it to possess a ‘tungstenatetrahedrane’-like core with short W–C distances[2.040(7),2.115(7), 2.133(7)Å].
Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population (2014)

Disease awareness was associated with lower HRQoL across the diseases studied, with PCS associations partially mediated by comorbidities. Equally importantly, undiagnosed disease was not associated with HRQoL deficits, which may partly explain why these individuals do not seek medical care.
S1138 Malnutrition and Post-ERCP Complications: Nationwide Inpatient Sample Database Analysis (2022)

Introduction: Complications can arise from endoscopic retrograde cholangiopancreatography (ERCP). Few studies have studied the relationship between malnutrition and post-ERCP complications. One study identified malnutrition as a risk factor for post-ERCP cholangitis. Another study found malnourished patients had increased post-ERCP inpatient mortality and higher risks for sepsis, hemorrhage, and intestinal perforation. We seek to elucidate the relationship between malnutrition and post-ERCP complications. Methods: The National Inpatient Sample database was used to identify hospitalized patients over 18 years old who had an ERCP procedure between 2007 - 2017 using ICD-9 and ICD-10 codes. Patients were divided into two groups, those with and without malnutrition. Primary outcomes were length of stay, payor status, and total charges. Secondary outcomes were rates of post-ERCP pancreatitis, cholangitis, cholecystitis, infection, hemorrhage, perforation, and overall mortality. Patients were matched by age, race, sex, and Elixhauser comorbidity index. Chi-squared tests compared categorical data, independent t-tests compared continuous data, and multivariate analyses assessed primary outcomes. Results: Of 282,526 patients who met inclusion criteria, 141,285 had malnutrition. For both groups, the mean ages were 67 years old with 49% males, 69.7% White and 11.6% Black. The Elixhauser Comorbidity Index was 19.8 in the malnutrition group and 15.0 in the control group. Primary outcomes were significant for length of stay (13.9 days vs 7.9 days, p< 0.001), payor status (p< 0.001) with more patients in the malnutrition group having Medicare or Medicaid, and higher total charges ($139,346 vs $80,136, p< 0.001). Secondary outcomes were significant (p< 0.001) for the odds ratio of post-ERCP pancreatitis (OR 2.3), perforation (OR 2.4), cholangitis (OR 1.8), cholecystitis (OR 3.6), infection (OR 3.3), hemorrhage (OR 3.8), and mortality (OR 2.0). Conclusion: Malnutrition can be characterized as increased catabolic state versus decreased anabolic state. Catabolism, which involves the body expending energy, can occur in response to an acute stressor. Decreased anabolism can occur due to food insecurity or feeding issues. Malnutrition increases morbidity and mortality for patients undergoing procedures. Our data shows malnourished patients have increased risks for multiple post-ERCP complications. Patients’ nutritional statuses should be assessed and optimized prior to ERCP.
Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing (2012)

Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing John Brothers II, Rebecca Kusko, Gang Liu, Lingqi Luo, Brenda Juan Guardela, John Tedrow, Yuriy Alekesyev, Ivana V Yang, Mick Correll, Mark Geraci, John Quackenbush, Frank Sciurba, Paola Sebastiani, Marc Lenburg, Naftali Kaminski, David A Schwartz, Avrum Spira, Jennifer Beane
Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia (2017)

Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter phase 1 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (N = 55). Moxetumomab pasudotox was administered as a 30-minute IV infusion at doses of 5 to 50 µg/kg every other day for 6 (cohorts A and B) or 10 (cohort C) doses in 21-day cycles. Cohorts B and C received dexamethasone prophylaxis against capillary leak syndrome (CLS). The most common treatment-related adverse events were reversible weight gain, hepatic transaminase elevation, and hypoalbuminemia. Dose-limiting CLS occurred in 2 of 4 patients receiving 30 µg/kg of moxetumomab pasudotox every other day for 6 doses. Incorporation of dexamethasone prevented further dose-limiting CLS. Six of 14 patients receiving 50 µg/kg of moxetumomab pasudotox for 10 doses developed hemolytic uremic syndrome (HUS), thrombotic microangiopathy (TMA), or HUS-like events, exceeding the MTCD. Treatment expansion at 40 µg/kg for 10 doses (n = 11) exceeded the MTCD because of 2 HUS/TMA/HUS-like events. Dose level 6B (ie, 50 µg/kg × 6 doses) was the MTCD, selected as the recommended phase 2 dose. Among 47 evaluable patients, an objective response rate of 32% was observed, including 11 (23%) composite complete responses, 5 of which were minimal residual disease negative by flow cytometry. Moxetumomab pasudotox showed a manageable safety profile and evidence of activity in relapsed or refractory childhood ALL. This trial was registered at www.clinicaltrials.gov as #NCT00659425.
Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701):  A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia (1997)

ADVERTISEMENT RETURN TO ISSUELetterNEXTSynthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3',4':4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701): A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia 1Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, Steven W. Elmore, Paul P. Ehrlich, Suzanne A. Lebold, Karin Tietje, Kevin B. Sippy, Michael D. Wendt, Daniel J. Plata, Fred Plagge, Steven A. Buckner, Michael E. Brune, Arthur A. Hancock, and James F. KerwinView Author Information Neurological and Urological Diseases Research, D-47C, and Process Research, D-45L, Abbott Laboratories, Abbott Park, Illinois 60064-3500 Cite this: J. Med. Chem. 1997, 40, 20, 3141–3143Publication Date (Web):September 26, 1997Publication History Received2 June 1997Published online26 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/jm970364ahttps://doi.org/10.1021/jm970364arapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views508Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Anatomy,Antagonists,Receptors,Selectivity Get e-Alerts
The role of excitons within the hole transporting layer in quantum dot light emitting device degradation (2019)

This work investigates the root causes of the limited stability of electroluminescent quantum dot light-emitting devices (QDLEDs). Studies using electrical measurements, continuous UV irradiation, and both steady-state and transient photoluminescence (PL) spectroscopy reveal that exciton-induced degradation of the hole transporting material (HTM) in QDLEDs plays a role in limiting their electroluminescence (EL) stability. The results indicate that there is a correlation between device EL stability and the susceptibility of the HTM to exciton-induced degradation. The presence of quenchers in the HTM layer can lead to a decrease in the luminescence quantum yield of QDs, suggesting that energy transfer between the QD and HTM films may play a role in this behavior. The results uncover a new degradation mechanism where excitons within the HTM limit the EL stability of QDLEDs.
Increased Stability Toward Oxygen Reduction Products for Lithium-Air Batteries with Oligoether-Functionalized Silane Electrolytes (2011)

The successful development of Li-air batteries would significantly increase the possibility of extending the range of electric vehicles. There is much evidence that typical organic carbonate based electrolytes used in lithium ion batteries form lithium carbonates from reaction with oxygen reduction products during discharge in lithium-air cells so more stable electrolytes need to be found. This combined experimental and computational study of an electrolyte based on a tri(ethylene glycol)-substituted trimethylsilane (1NM3) provides evidence that the ethers are more stable toward oxygen reduction discharge species. X-ray photoelectron spectroscopy (XPS) and FTIR experiments show that only lithium oxides and no carbonates are formed when 1NM3 electrolyte is used. In contrast XPS shows that propylene carbonate (PC) in the same cell configuration decomposes to form lithium carbonates during discharge. Density functional calculations of probable decomposition reaction pathways involving solvated oxygen reduction species confirm that oligoether substituted silanes, as well as other ethers, are more stable to the oxygen reduction products than propylene carbonate. These results indicate that the choice of electrolyte plays a key role in the performance of Li-air batteries.
Incommensurately Modulated Crystal Structure and Photoluminescence Properties of Eu2O3- and P2O5-Doped Ca2SiO4 Phosphor (2019)

We prepared four types of Eu<sub>2</sub>O<sub>3</sub>- and P<sub>2</sub>O<sub>5</sub>-doped Ca<sub>2</sub>SiO<sub>4</sub> phosphors with different phase compositions but identical chemical composition, the chemical formula of which was (Ca<sub>1.950</sub>Eu<sup>3+</sup><sub>0.013</sub>☐<sub>0.037</sub>)(Si<sub>0.940</sub>P<sub>0.060</sub>)O<sub>4</sub> (☐ denotes vacancies in Ca sites). One of the phosphors was composed exclusively of the incommensurate (IC) phase with superspace group <i>Pnma</i>(0<i>β</i>0)00<i>s</i> and basic unit-cell dimensions of <i>a</i> = 0.68004(2) nm, <i>b</i> = 0.54481(2) nm, and <i>c</i> = 0.93956(3) nm (<i>Z</i> = 4). The crystal structure was made up of four types of β-Ca<sub>2</sub>SiO<sub>4</sub>-related layers with an interlayer. The incommensurate modulation with wavelength of 4.110 × <i>b</i> was induced by the long-range stacking order of these layers. When increasing the relative amount of the IC-phase with respect to the coexisting β-phase, the red light emission intensity, under excitation at 394 nm, steadily decreased to reach the minimum, at which the specimen was composed exclusively of the IC-phase. The coordination environments of Eu<sup>3+</sup> ion in the crystal structures of β- and IC-phases might be closely related to the photoluminescence intensities of the phosphors.
ChemInform Abstract: Selective Catalytic Hydrogenation of Nitro Groups in the Presence of Activated Heteroaryl Halides. (2012)

Abstract An efficient and widely applicable method is presented
MEMS Piezo Pressure Sensor for Military Applications (2004)

The structural integrity and ballistic accuracy of gun-launched projectiles are related to the in-bore environment, and to date, these parameters cannot be routinely measured. The ability to measure these quantities and to compare them to design parameters during the system development would vastly improve the performance and reliability of projectiles. Insertion of smart material MEMS (Micro-machined Electro-Mechanical Systems) sensors into projectiles will provide the methodology required to develop more precise and lethal projectiles for future combat systems.
Hydrolysis profiling: An in vitro methodology to predict in vivo absorption time (2013)

An in vitro method was developed for estimating in vivo degradation time of sutures made from synthetic bioresorbable polyesters. Model compounds and a number of commercially available bioresorbable suture products were used to establish the applicability of this hydrolysis profile methodology. Hydrolysis profiles on tested bioresorbable sutures were determined as a function of size and chemical composition. This method of accelerated absorption testing may shorten product development time and reduce the need for animal testing. In addition, the methodologies presented have the potential to provide insight into the loss of mechanical properties with time.
Ion Channels from Linear and Branched Bola‐Amphiphiles. (2003)

The synthesis and characterization of the ion channel activity of three new bola-amphiphiles is\ndescribed. These compounds are conceptually derived from a previously reported bis-cyclophane\nbola-amphiphile through opening of the cyclophanes to acyclic structures and were found to readily\nform ion channels in planar bilayer membranes as assessed by bilayer clamp single-channel analysis.\nAll three compounds behaved very similarly: the dominant channels formed by all three are Ohmic\nwith specific conductance of 10 ± 1 pS (NaCl electrolyte) and 39 ± 1 pS (CsCl electrolyte). Single-ion permeability ratios, determined from dissymmetric electrolyte experiments, showed the\nselectivity &lt;i&gt;P&lt;/i&gt;(Cs&lt;sup&gt;+&lt;/sup&gt;) &gt; &lt;i&gt;P&lt;/i&gt;(Na&lt;sup&gt;+&lt;/sup&gt;) &gt; &lt;i&gt;P&lt;/i&gt;(Cl&lt;sup&gt;-&lt;/sup&gt;). Less frequently, lower conductance channels were also observed\nto act independently of the dominant channels. The lifetimes of the dominant channels range from\n70 to 280 ms for the three compounds with some very long-lived openings (20−40 s) observed for\ntwo of the three. The lower conductance states have shorter lifetimes. This study demonstrates\nthat bis-macrocyclic compounds are not essential for channel formation by bola-amphiphiles, and\nopens a new class of channel-forming compounds for structure−activity optimization.
Modified growth kinetics of ion induced yttrium–silicide layers during subsequent thermal annealing (1991)

Yttrium and amorphous silicon bilayers were irradiated with 600-keV inert ions between −190 and 265 °C. Ion-induced YSi1.7 layers occurred in those samples irradiated above ≥ (R18)205 °C. These ion-mixed samples were thermally annealed at temperatures between 325 and 380 °C. The diffusion-limited growth was observed only in those samples which had an ion-induced YSi1.7 layer present prior to thermal annealing. This type of growth is distinctly different from the interface limited, nonuniform, and irreproducible growth seen during typical thermal annealing of yttrium and silicon bilayers. This type of growth still occurred in those samples annealed after ion irradiations at ≤190 °C.
Interface and thickness tuning for blade coated small-molecule organic light-emitting diodes with high power efficiency (2013)

We developed a general method based on fluorescence microscopy to characterize the interface dissolution in multi-layer organic light-emitting diodes (OLEDs) by blade coating. A sharp bi-layer edge was created before blade coating, with the bottom layer being insoluble and top layer soluble. After blade coating, fluorescence images showed that the edge of the top layer shifted when the layer dissolved completely, whereas the bottom layer's edge remained in place as a positioning mark. The dissolution depth was determined to be 15–20 nm when the emissive-layer host of 2,6-bis (3-(9H-carbazol-9-yl)phenyl) pyridine (26DCzPPy) was coated on the hole-transport layer of N,N′-bis(naphthalen-1-yl)-N,N′-bis(phenyl)-benzidine(NPB), which was consistent with a sudden drop in efficiency of orange OLEDs with layer thickness below 20 nm. Thus, the layer thickness of OLEDs was optimized to stay more than 20 nm for blade coating. For a two-color white OLED with the structure TCTA/26DCzPPy:PO-01-TB:FIrpic/TPBI, efficiency was 24 cd/A and 8.5 lm/W at 1000 cd/m2. For a three-color white OLED with Os(fptz)2(dhpm) added as the emitter, the efficiency was 12.3 cd/A and 3.7 lm/W at 1000 cd/m2. For a green device with the structure TCTA/26DCzPPy:Ir(mppy)3/TPBI, the efficiency was 41.9 cd/A and 23.4 lm/W at 1000 cd/m2.
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis (2011)

The ubiquitin-editing enzyme A20 (tumor necrosis factor-α-induced protein 3) serves as a critical brake on nuclear factor κB (NF-κB) signaling. In humans, polymorphisms in or near the A20 gene are associated with several inflammatory disorders, including psoriasis. We show here that epidermis-specific A20-knockout mice (A20(EKO)) develop keratinocyte hyperproliferation, but no signs of skin inflammation, such as immune cell infiltration. However, A20(EKO) mice clearly developed ectodermal organ abnormalities, including disheveled hair, longer nails and sebocyte hyperplasia. This phenotype resembles that of mice overexpressing ectodysplasin-A1 (EDA-A1) or the ectodysplasin receptor (EDAR), suggesting that A20 negatively controls EDAR signaling. We found that A20 inhibited EDAR-induced NF-κB signaling independent from its de-ubiquitinating activity. In addition, A20 expression was induced by EDA-A1 in embryonic skin explants, in which its expression was confined to the hair placodes, known to be the site of EDAR expression. In summary, our data indicate that EDAR-induced NF-κB levels are controlled by A20, which functions as a negative feedback regulator, to assure proper skin homeostasis and epidermal appendage development.