gebhart/patrepeval huggingface dataset:
Formation of readiness for professional activity of technical university students as a psychological and pedagogical problem (2023)

Based on the results of empirical research, the article shows that higher education should consider the process of formation of students' readiness for professional activity as a psychological and pedagogical problem. This is due to the current system of vocational guidance in secondary schools. As a result, most applicants have no idea about their chosen profession. This makes the problem of forming students' professional readiness for future activities an urgent task of the higher education system. It is shown on the results of the study that, in the opinion of the students themselves, such a task can and should be solved. The results of the study are described, the purpose of which was to identify the level of readiness of students to perform professional activities. The forms of formation of students' readiness for professional activity are considered. Considering the problem of a person's readiness for professional activity in the article, a personality-oriented component containing the properties and qualities of a future specialist is defined as a component, according to psychology. Based on empirical data, it is concluded that the professional readiness in demand today as a set of competencies of a graduate of a higher school, acting as socially significant integrative qualities that are in demand in the field of further professional activity and personal improvement, is the basis of high-quality professional education.
Optoelectronic Smart Pixels Monallithically Integrated (2005)

The paper discusses a fabrication process for monolithically integrating MESFETs, photodiodes and light sources intended for use with PMPE optics. This process is compatible with different types of light sources such as a surface emitting LED. These smart pixel arrays are expected to be a key element in massively parallel data processing systems.
Reconstitution of immune cell interactions in free-standing membranes (2018)

Abstract The spatiotemporal regulation of signalling proteins at the contacts formed between immune cells and their targets determines how and when immune responses begin and end. It is important, therefore, to be able to elucidate molecular processes occurring at these interfaces. However, the detailed investigation of each component’s contribution to the formation and regulation of the contact is hampered by the complexity of cellular composition and architecture. Moreover, the transient nature of these interactions creates additional challenges, especially for using advanced imaging technology. One approach to circumventing these problems is to establish in vitro systems that faithfully mimic immune cell interactions, incorporating complexity that can be ‘dialled-in’ as needed. Here, we present an in vitro system making use of synthetic vesicles that mimic important aspects of immune cell surfaces. Using this system, we begin to investigate the spatial distribution of signalling molecules (receptors, kinases and phosphatases) and the intracellular rearrangements that accompany the initiation of signalling in T cells. The model system presented here is expected to be widely applicable. Summary Statement Immune cell-cell interactions are reconstituted in free-standing vesicles wherein spatiotemporal aspects of immune synapse formation can be investigated.
A wide common-mode fully-adaptive multi-standard 12.5Gb/s backplane transceiver in 28nm CMOS (2012)

This paper describes the design of a fully-adaptive backplane transceiver embedded in a state-of-the-art, low-leakage, 28nm CMOS FPGA. The receive AFE utilizes a three-stage CTLE to provide selective frequency boost for long-tail ISI cancellation. A 5-tap speculative DFE removes the immediate post-cursor ISI. Both CTLE and DFE are fully adaptive using sign-sign LMS algorithm. A novel clocking technique uses wideband LC and ring oscillators for reliable clocking from 0.6-12.5Gb/s operation. The transmitter utilizes a 3-tap FIR and provides flexibility for supply and ground referenced operation. The transceiver achieves BER <; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-15</sup> over a 33dB-loss backplane at 12.5Gb/s and over channels with 10G-KR characteristics at 10.3125Gb/s.
In Situ Fluorescence Probing of Molecular Mobility and Chemical Changes during Formation of Dip-Coated Sol−Gel Silica Thin Films (1999)

Pyranine (trisodium 8-hydroxy-1,3,6-pyrenetrisulfonate) and PRODAN (6-propionyl-2-(dimethylamino)naphthalene) are used as in situ fluorescence probes to monitor the molecular mobility and chemical evolution during sol−gel silica thin film deposition by the dip-coating process. Measurements are made on the evolving film as it emerges from the sol at thicknesses changing from <4 μm for the starting film to 300 nm for the final film. The thickness is monitored by interferometry. Results of the spatially resolved fluorescence depolarization for films withdrawn from a fresh sol show that the tumbling motion of both probes is retained until the final deposition stage when an extensive cross-linking silica framework forms. Intermediate probe mobility occurs at an earlier time in films pulled from an aged sol. A comparison between thin film deposition and monolith formation is made.
Stereochemical Elucidation of the Pentacyclopropane Antifungal Agent FR-900848 (1996)

Full structural elucidation of FR-900848, an antifungal pentacyclopropane nucleoside natural product from Streptoverticillium fervens, is reported. A series of model compounds were prepared using multiple asymmetric Simmons−Smith cyclopropanation reactions. Comparisons of spectroscopic data of synthetic alkenes 9 and 10, quatercyclopropanes 11 and 12, and imidazolidines 13 and 14 with FR-900848 and its degradation products 2, 3, and 4 were consistent with the full structural assignment of the natural product as structure 7.
[Psychiatric disorders in juvenile myoclonic epilepsy]. (2001)

Mild personality problems have been described in patients with juvenile myoclonic epilepsy (JME), but clinical practice shows that JME can be diagnosed in patients with more or less severe psychiatric disorders (PD). The presence in JME patients of personality disorders has been described repeatedly, but never quantified. We thus decided to evaluate, using the DSM IV, the current prevalence and types of PD in a large series of consecutive, newly referred patients with JME. Among 170 consecutive JME cases referred to two departments of epileptology (Marseilles and Nice) between 1981 and 1998 (66 males, 104 females; aged 11.7-70; mean+/-SD 32.4+/-10.4 follow-up 12.7+/-10 [0.5-52]), we found 45 patients (26.5p.100) with PD. According to the DSM IV, they could be classified as severe mental retardation (main diagnosis) (one case); pervasive developmental disorders (2 cases); tic disorder (1 case); enuresis (1 case); psychotic disorders (5 cases, including schizophrenia paranoid type (1 case), disorganized type (1 case), delusional disorder (1 case), unspecified (2 cases)); depressive disorders (3 cases); generalized anxiety (6 cases); anorexia nervosa (2 cases); personality disorders (24 cases, including borderline personality (11 cases), dependent personality (5 cases), histrionic personality (2 cases), obsessive-compulsive personality (1 case), not specified (5 cases)). Sudden unexplained death occurred in 2 cases (borderline personality and pervasive developmental disorder not otherwise specified, respectively) and death due to pneumonia in 1 cases (anorexia). Although uncommonly severe cases of JME may have been selected in our referral centers, it appears that JME may be associated with PD. Comparatively mild personality disorders are the most common finding, and may be part of the clinical picture to some extent, while severe PD are less common, and probably coincidental. The presence of PD does not exclude the diagnosis of JME, and PD may represent a further challenge in the comprehensive care of these patients.
Purification of the 33,000‐dalton ligand binding‐protein constituent of the lymphoblast substance P receptor (1987)

Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000, 78,000, and 116,000 can be specifically affinity labeled using [125I]-SP Bolton-Hunter reagent and disuccinymidyl suberate (DSS). Peptide-mapping studies of these individually purified affinity labeled proteins have shown that the 33,000 MW membrane protein is present in the higher molecular weight cross-linked proteins. In the present studies, the 33,000 MW affinity-labeled protein was purified using semipreparative sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) followed by high-performance hydroxylapatite chromatography. Starting with 800 mg of affinity-labeled protein, the final yield was 39.0 micrograms of 33,000 MW affinity-labeled protein. Based on an estimate of 53 mg receptor per 800 mg membrane protein, this represents an overall yield of greater than 70%. Peptide mapping was done by digesting 20 micrograms of the receptor protein with bovine trypsin. The proteolytic fragments were separated by reverse-phase high-performance liquid chromatography, and the amino acid content of 13 distinct peptides was determined. With this procedure, sufficient receptor can now be purified so that partial amino acid sequences can be obtained for further structural studies.
Intelligent control for automotive manufacturing-rule based guided adaptation (2002)

Numerous industrial control problems, especially in automotive manufacturing, deal with control of MIMO nonlinear systems that are either static or have dynamics that can be ignored with respect to the sampling rate. <P xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We expand the adaptive control algorithm by introducing a new control law that is derived from the LQR design. We analyze the convergence of the adaptive control algorithm under this control law and compare it to the control law based on the modified Levenberg-Marquardt (LM) algorithm. We also demonstrate how these two control laws can be dynamically adjusted to handle control constraints. Finally, we revise and simplify the algorithm for generation of the rule base of initial conditions.</P>
Security analysis of the message authenticator algorithm (MAA) (1997)

Abstract The security of the ISO banking standard Message Authenticator Algorithm (ISO 8731‐2), also known as MAA, is considered. The attacks presented herein, which exploit the internal structure of the algorithm, are the first computationally feasible attacks on MAA. First a MAC forgery attack is presented that requires 2 17 messages of 256 kbytes or 2 24 messages of 1 kbyte; the latter circumvents the special MAA mode for long messages defined in the standard. Next a key recovery attack on MAA is described which requires 2 32 chosen texts consisting of a single message block. The number of off‐line multiplications for this attack varies between 2 44 for one key in 1000 to about 2 51 for one key in 50. This should be compared to about 3 2 65 multiplications for an exhaustive key search. Finally it is shown that MAA has 2 33 keys for which it is rather easy to create a large cluster of collisions. These keys can be detected and recovered with 2 27 chosen texts. From these attacks follows me identification of several classes of weak keys for MAA.
A REVIEW OF TELEOPERATION SYSTEM CONTROL (2003)

This work presents a survey of control methods applied to teleoperation systems. Although the topic is kept general, emphasis in the review is placed on force-reflecting manual controllers, which experience time delays, and suffer stability problems. Various theoretical and experimental methods that have been developed over the years are presented and the more promising ones are outlined for further study, and development of efficient, real-time control software, which is the ultimate goal of the current work.
An Approach to α-Keto Vinyl Carbinols (2011)

Adducts from the radical addition of xanthates to ethyl vinyl sulfide readily undergo elimination of the xanthate group upon thermolysis to give vinylic and/or allylic sulfides, depending on the structure. In the case of α-xanthyl ketones, the adducts are converted into α-keto vinyl carbinols by rearrangement of the sulfoxides derived from the vinylic and allylic sulfides.
Exciton Dynamics in Carbon Nanotubes (2007)

Abstract not Available.
The effect of surface interactions on the viscosity of polymer thin films (2006)

We have measured the viscosity of thin polymer films as a function of film thickness using three independent techniques. The results of all methods indicated that the viscosity of the film increases about two orders of magnitude near the solid substrate. Measurements performed on split layer substrates indicated that a layer of polymer chains remained permanently adsorbed at the Si substrate. This layer was responsible for trapping subsequent layers, and propagating the effect of surface interactions to chains without direct contacts to the solid substrate. If this layer was applied prior to the rest of the film, it can screen the surface interactions and even initiate auto-dewetting of other chemically identical layers above it.
Tables S1 - S10 from Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition (2023)

&lt;p&gt;An excel file containing Supplementary Tables S1 - S10&lt;/p&gt;
Venice Chart International Consensus Document on Atrial Fibrillation Ablation: 2011 Update (2012)

Peer Reviewed
Latency Constrained Simultaneous Wireless Information and Power Transfer (2021)

This paper studies a power splitting (PS)-based simultaneous wireless information and power transfer (SWIPT) multi-user system. Specifically, an optimization problem is formulated to minimize the average transmit power of the base station (BS) by jointly optimizing the transmit beamformer and receive PS ratios, while meeting user-specific latency and energy harvesting (EH) requirements. We employ the Lyapunov optimization framework and provide a dynamic control algorithm for the time-average problem. The coupled and non-convex constraints are handled via the Successive Convex Approximation (SCA) technique, and a low-complexity iterative algorithm, where each step is computed in closed-form, is proposed by solving a system of Karush-Kuhn-Tucker (KKT) optimality conditions. The numerical results provide insights on the robustness of the proposed design to realize a power-efficient SWIPT system while ensuring latency and EH requirements in a dynamic network.
Supplementary Figure 1 from Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target (2023)

&lt;p&gt;PDF file - 576K, Immunohistochemical staining of patient #946's urethra metastasis (A) and LTL352 xenograft (B) for AR protein. Panels C and D show staining of the patient's urethra metastasis and xenograft respectively for TP63 protein.&lt;/p&gt;
Frequency Synthesis for 60 GHz OFDM Systems (2005)

This paper presents a frequency plan for a super-heterodyne OFDM transceiver for the 60 GHz band. We derive an approximation for the rms phase error of the phase-locked loop (PLL). The phase error is related to the phase noise levels of the voltage- controlled oscillator (VCO) and the crystal reference, the PLL division factor, the second-order loop pa- rameters, and the OFDM carrier spacing. We verify our approach by comparison with the simulated phase error and BER including correction of the common phase error for a 16-QAM OFDM system. The model drastically simplifies noise optimization of PLLs.
A Multicomponent Ni‐, Zr‐, and Cu‐Catalyzed Strategy for Enantioselective Synthesis of Alkenyl‐Substituted Quaternary Carbons (2014)

The availability of enantiomerically enriched carbonyl-containing compounds is essential to the synthesis of biologically active molecules. Since catalytic enantioselective conjugate addition (ECA) reactions directly generate the latter valuable class of molecules, the design and development of such protocols represents a compelling objective in modern chemistry. Herein, we disclose the first solution to the problem of ECA of alkenyl groups to acyclic trisubstituted enones, an advance achieved by adopting an easily modifiable and fully catalytic approach. The requisite alkenylaluminum reagents are synthesized with exceptional site- and/or stereoselectivity by a Ni-catalyzed hydroalumination process, and the necessary enones are prepared through a site- and stereoselective zirconocene-catalyzed carboalumination/acylation reaction. The all-catalytic procedure is complete within four hours, furnishing the desired products in up to 77 % overall yield and 99:1 enantiomeric ratio.
The Effect of Flooring Surface Compliance on Plantar Pressures and Discomfort During Prolonged Standing. (2011)

Prolonged standing is common in the workplace, and is a cause of pain and discomfort in the feet, legs, and lower back. Anti-fatigue mats are often used in industry to reduce discomfort resulting from prolonged standing. However, there are currently no means for predicting the effectiveness of a particular mat in mitigating discomfort, and there is little understanding of how discomfort develops during prolonged standing. The main objective of this research was to investigate the cause of discomfort during prolonged standing, and the role of mats in reducing discomfort. The effect of flooring material properties on discomfort and behavior was investigated during four-hour periods of standing. Touch sensitivity of the foot was also measured before and after standing to test for changes in sensitivity. Plantar pressure was investigated as a potential mechanism for discomfort during standing by testing the pain-pressure threshold at different levels of constant pressures on the foot. Finally, the effects of flooring and shoes on plantar pressure were studied. During prolonged standing, mats reduced discomfort when compared to a hard floor, but no differences in discomfort were observed among mats. During standing, weight-shifting was correlated to discomfort and demonstrated lower statistical variance than subjective ratings of discomfort. These findings suggest that weight-shifting may offer a more sensitive measurement for discomfort than subjective ratings. Finally, as a result of prolonged standing, touch sensitivity of the feet increased, suggesting potential unintended bias in clinical touch sensitivity testing. During pain-pressure threshold testing, elevated levels of constant plantar pressure were associated with an earlier onset of pain, indicating that plantar pressure is a mechanism that contributes discomfort. Flooring significantly affected plantar pressure during barefoot standing and walking, but when shoes were worn the effects of flooring on pressure were very small or not significant. This suggests that for reducing plantar pressure, attention should be focused on the design of footwear rather than the design of mats. Because flooring does not affect plantar pressure, mats must reduce discomfort through some other unknown mechanism.
The reduced form of the antibody CH2 domain (2021)

Among the immunoglobulin domains, the CH2 domain has the lowest thermal stability, which also depends on amino acid sequence and buffer conditions. To further identify factors that influence CH2 folding and stability, we characterized the domain in the reduced form using differential scanning fluorimetry and nuclear magnetic resonance. We show that the CH2 domain can fold, similarly to the disulfide-bridged form, without forming a disulfide-bridge, even though the protein contains two Cys residues. Although the reduced form exhibits thermal stability more than 15°C lower than the disulfide-bridged form, it does not undergo immediate full oxidization. To explain this phenomenon, we compared CH2 oxidization at different conditions and demonstrate a need for significant fluctuation of the folded conformation to enhance CH2 disulfide-bridge formation. We conclude that, since CH2 can be purified as a folded, semi-stable, reduced protein that can coexist with the oxidized form, verification of the level of oxidization at each step is critical in CH2 engineering studies.
Cellular Level Classification of Breast Cancer Through Proteomic Markers Using Nanochannel Array Sensors (2013)

Aims: A nanochannel-based sensor for cellular level classification of breast cancer metastasis has been designed. Our approach to the classification of cell’s likelihood to metastasize is based on screening for levels of expression of specific proteomic biomarkers associated with breast cancer stem cells. Materials & methods: Proteomic activity for four breast cancer cell lines for three specific markers (PDGFR, ALDH1A1 and ALDH1A3) was quantified. The nanochannel sensor is an electrochemical immunoassay and comprises of alumina nanochannel arrays integrated on to a gold microelectronic platform. The sensor operates on the principle of electrochemical impedance spectroscopy. Results & conclusion: Test cell lysate samples from SUM159 invasive, SUM159 noninvasive, HC1143 and DCIS cell lines were classified as those having a high likelihood of metastases based on the levels of proteomic activity evaluated against the three key markers. The lowest proteomic activity measured was 0.1 ng/ml with PDGFR, 100 ng/ml with ALDH1A1 and 100 ng/ml with ALDH1A3, correlating to the detection of unit stem cell count. Original submitted 9 November 2012; Revised submitted 29 July 2013
QoS Based Multicast Routing for Multimedia Communications (1997)

Quality of service (QoS) routing is important to support emerging multicast multimedia services. In this paper, we propose a routing metric and use it with two heuristic algorithms to find the multicast tree for guaranteed QoS services. The simulation results shows a marked improvement in network utilizations expressed in terms of cost over other proposed schemes like QOSPF.
Na3MnZr(PO4)3: A High-Voltage Cathode for Sodium Batteries (2018)

Sodium batteries have been regarded as promising candidates for large-scale energy storage application, provided cathode hosts with high energy density and long cycle life can be found. Herein, we report NASICON-structured Na<sub>3</sub>MnZr(PO<sub>4</sub>)<sub>3</sub> as a cathode for sodium batteries that exhibits an electrochemical performance superior to those of other manganese phosphate cathodes reported in the literature. Both the Mn<sup>4+</sup>/Mn<sup>3+</sup> and Mn<sup>3+</sup>/Mn<sup>2+</sup> redox couples are reversibly accessed in Na<sub>3</sub>MnZr(PO<sub>4</sub>)<sub>3</sub>, providing high discharge voltage plateaus at 4.0 and 3.5 V, respectively. A high discharge capacity of 105 mAh g<sup>-1</sup> was obtained from Na<sub>3</sub>MnZr(PO<sub>4</sub>)<sub>3</sub> with a small variation of lattice parameters and a small volume change on extraction of two Na<sup>+</sup> ions per formula unit. Moreover, Na<sub>3</sub>MnZr(PO<sub>4</sub>)<sub>3</sub> exhibits an excellent cycling stability, retaining 91% of the initial capacity after 500 charge/discharge cycles at 0.5 C rate. On the basis of structural analysis and density functional theory calculations, we have proposed a detailed desodiation pathway from Na<sub>3</sub>MnZr(PO<sub>4</sub>)<sub>3</sub> where Mn and Zr are disordered within the structure. We further show that the cooperative Jahn-Teller distortion of Mn<sup>3+</sup> is suppressed in the cathode and that Na<sub>2</sub>MnZr(PO<sub>4</sub>)<sub>3</sub> is a stable phase.