gebhart/patrepeval huggingface dataset:
Highly Stereoselective Intramolecular Addition of a Hydroxyl Group to Vinylsilanes via 1,2-Silyl Migration1 (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHighly Stereoselective Intramolecular Addition of a Hydroxyl Group to Vinylsilanes via 1,2-Silyl Migration1Katsukiyo Miura, Takeshi Hondo, Hiroshi Saito, Hajime Ito, and Akira HosomiView Author Information Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Cite this: J. Org. Chem. 1997, 62, 24, 8292–8293Publication Date (Web):November 28, 1997Publication History Received7 October 1997Published online28 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/jo971847phttps://doi.org/10.1021/jo971847prapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views428Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cyclization,Genetics,Ions,Isomerization,Reactivity Get e-Alerts
ChemInform Abstract: Rapid, General Access to Chiral β‐Fluoroamines and β,β‐Difluoroamines via Organocatalysis. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tightly coupled precise point positioning and attitude determination (2015)

A method is described for joint precise point positioning and attitude determination with tight coupling of two single-frequency low-cost global navigation satellite system receivers and an inertial sensor. The sensor fusion is performed with an extended Kalman filter. The carrier phase ambiguities are determined in a constrained tree search using soft a priori information on the antenna distance. A code multipath parameter is determined for each satellite to improve the accuracy. Ionospheric corrections are estimated also by single-frequency receivers.
Recovering Population Parameters from a Single Gene Genealogy: An Unbiased Estimator of the Growth Rate (2010)

We show that the number of lineages ancestral to a sample, as a function of time back into the past, which we call the number of lineages as a function of time (NLFT), is a nearly deterministic property of large-sample gene genealogies. We obtain analytic expressions for the NLFT for both constant-sized and exponentially growing populations. The low level of stochastic variation associated with the NLFT of a large sample suggests using the NLFT to make estimates of population parameters. Based on this, we develop a new computational method of inferring the size and growth rate of a population from a large sample of DNA sequences at a single locus. We apply our method first to a sample of 1,212 mitochondrial DNA (mtDNA) sequences from China, confirming a pattern of recent population growth previously identified using other techniques, but with much smaller confidence intervals for past population sizes due to the low variation of the NLFT. We further analyze a set of 63 mtDNA sequences from blue whales (BWs), concluding that the population grew in the past. This calls for reevaluation of previous studies that were based on the assumption that the BW population was fixed.
The clock distribution system for the ATLAS Liquid Argon Calorimeter Phase-I Upgrade Demonstrator (2015)

A prototype Liquid-argon Trigger Digitizer Board (LTDB), called the LTDB Demonstrator, has been developed to demonstrate the functions of the ATLAS Liquid Argon Calorimeter Phase-I trigger electronics upgrade. Forty Analog-to-Digital converters and four FPGAs with embedded multi-gigabit-transceivers on each Demonstrator need high quality clocks. A clock distribution system based on commercial components has been developed for the Demonstrator. The design of the clock distribution system is presented. The performance of the clock distribution system has been evaluated. The components used in the clock distribution system have been qualified to meet radiation tolerance requirements of the Demonstrator.
Hemodynamic Effects of Mechanical Circulatory Support Devices in Ventricular Septal Defect (2019)

Although no form of percutaneous MCS normalized hemodynamics in AMI-VSD, pulmonary capillary wedge pressure and shunting were worsened by extracorporeal membrane oxygenation and improved by Impella. Accordingly, based on hemodynamics alone, Impella provides the optimal form of support in AMI-VSD. However, other factors, including team experience, device availability, potential for tissue ingestion, and clinical characteristics, need to be considered when choosing a percutaneous MCS device for AMI-VSD.
Analysis of residual coronary artery motion for breath hold and navigator approaches using real‐time coronary MRI (2006)

Coronary artery MRI methods utilize breath holds, or diaphragmatic navigators, to compensate for respiratory motion. To increase image quality and navigator (NAV) gating efficiency, slice tracking is used, with more sophisticated affine motion models recently introduced. This study assesses the extent of remaining coronary artery motion in free breathing NAV and single and multi breath hold coronary artery MRI. Additionally, the effect of the NAV gating window size was examined. To visualize and measure the respiratory induced motion, an image containing a coronary artery cross section was acquired at each heartbeat. The amount of residual coronary artery displacement was used as a direct measure for the performance of the respiratory motion correction method. Free breathing studies with motion compensation (slice tracking with 5 mm gating window) had a similar amount of residual motion (0.76+/-0.17 mm) as a single breath hold (0.52+/-0.20 mm) and were superior to multiple breath holds (1.22+/-0.60 mm). Affine NAV methods allowed for larger gating windows ( approximately 10 mm windows) with similar residual motion (0.74+/-0.17 mm). In this healthy adult cohort (N=10), free-breathing NAV methods offered respiratory motion suppression similar to a single breath hold.
Injectable Polymer‐Nanoparticle Hydrogel for the Sustained Intravitreal Delivery of Bimatoprost (2022)

Abstract Vision impairment resulting from chronic eye diseases, such as macular degeneration and glaucoma, severely impacts patients’ quality of life and poses an immense global financial burden. Current standard of care for such diseases includes daily eye drops or frequent intravitreal (ITV) injections, which are burdensome treatment modalities resulting in low patient compliance. There remains a growing need for easily administered long‐acting delivery technologies for prolonging exposure of ocular therapeutics with each administration. Here, this work deploys a supramolecular polymer‐nanoparticle (PNP) hydrogel for ITV delivery of the glaucoma drug bimatoprost. PNP hydrogels are shear‐thinning and self‐healing, key properties for injectability, and enable slow release of molecular cargo in vitreous humor (VH) mimics. An in vivo study in New Zealand white rabbits demonstrated intravitreally injected PNP hydrogels form depots that degrade slowly over time, maintaining detectable levels of bimatoprost in the VH up to 8 weeks following injection. Ophthalmic examinations and histopathology identified a mild foreign body response (FBR) to the hydrogel, characterized by rare clusters of foamy macrophages and giant cells associated with minimal, patchy fibroplasia. This work shows that PNP hydrogels exhibit numerous desirable traits for sustained drug delivery and further work will be necessary to optimize tolerability in the eye.
Figure S6 from A Novel Theranostic Strategy for <i>MMP-14</i>–Expressing Glioblastomas Impacts Survival (2023)

&lt;p&gt;Biodistribution and toxicity data from CLIO-ICT-treated mice&lt;/p&gt;
High coercive FePt and FePt-SiNx(001) films with small grain size and narrow opening-up of in-plane hysteresis loop by TiN intermediate layer (2011)

The effects of a TiN intermediate layer on the epitaxial growth and magnetic properties of FePt films were investigated. It was found that 5 nm TiN can effectively block the diffusion of a CrRu underlayer into a FePt magnetic layer and the magnetic dead layer on the TiN layer was negligible. Compared with an FePt film grown on a MgO intermediate layer, FePt film grown on a TiN interlayer exhibited very high out-of-plane coercivity and very narrow opening-up of in-plane hysteresis loop. With doping 40 vol. % SiNx in FePt film the grain size was reduced to 5.5 nm and the magnetic properties, such as high out-of-plane coercivity and line-like in-plane hysteresis loop, were retained.
Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4 (2021)

<b>Rationale:</b> The molecular mechanisms underlying the pathogenesis of systemic insulin resistance in type 2 diabetes remain elusive. Growth hormone receptor (GHR) deficiency has long been known to improved insulin sensitivity. However, whether hepatic GHR overexpression or activation is a cause of insulin resistance is still unknown. The aim of this study was to identify the new role of GHR in systemic insulin resistance and explore the underlying mechanism. <b>Method:</b> Different samples obtained from obese humans, <i>ob/ob</i> mice, <i>db/db</i> mice, high-fat diet (HFD)-fed mice and primary mouse hepatocytes were used to evaluate the correlations between GHR and metabolic disorders. Recombinant adeno-associated viruses encoding GHR and STAT5 and GHR knockout mice were used to investigate the roles of hepatic GHR in glucose homeostasis. Tissue H&E, Oil Red O and PAS staining were performed for histomorphological analysis. Gel filtration chromatography was employed for the separation of serum RBP4-TTR complexes. Plasmids (related to GHR, STAT5 and HIF1α), siRNA oligos (siGHR and siSTAT5), luciferase activity and ChIP assays were used to explore the potential mechanism of hepatic GHR. <b>Results:</b> Here, we found that hepatic GHR expression was elevated during metabolic disorder. Accordingly, hepatic GHR overexpression disrupted systemic glucose homeostasis by promoting gluconeogenesis and disturbing insulin responsiveness in the liver. Meanwhile, hepatic GHR overexpression promoted lipolysis in white adipose tissue and repressed glucose utilization in skeletal muscle by promoting the circulating level of RBP4, which contributed to impaired systemic insulin action. A mechanistic study revealed that hepatic GHR disrupted systemic insulin sensitivity by increasing RBP4 transcription by activating STAT5. Additionally, overexpression of hepatic GHR promoted TTR transcriptional levels by enhancing the expression of HIF1α, which not only increased the protein stability of RBP4 but also inhibited renal clearance of RBP4 in serum. <b>Conclusions:</b> Hepatic GHR overexpression and activation accelerated systemic insulin resistance by increasing hepatic RBP4 production and maintaining circulating RBP4 homeostasis. Our current study provides novel insights into the pathogenesis of type 2 diabetes and its associated metabolic complications.
Synthesis of Macrocyclic Insect-Derived Alkaloids (2000)

Macrocyclic lactonic alkaloids found in the pupal secretions of two species of a coccinellid beetle (genus Epilachna) were prepared in enantiomerically pure form via an efficient synthetic route using enantiomerically pure α-amino acids as chiral-pool starting materials. Macrocycles with rings containing up to 98 atoms were synthesized in good yield using Mukaiyama's macrolactonization conditions.
Radiation-Hard Complementary Integrated Circuits Based on Semiconducting Single-Walled Carbon Nanotubes (2017)

Increasingly complex demonstrations of integrated circuit elements based on semiconducting single-walled carbon nanotubes (SWCNTs) mark the maturation of this technology for use in next-generation electronics. In particular, organic materials have recently been leveraged as dopant and encapsulation layers to enable stable SWCNT-based rail-to-rail, low-power complementary metal-oxide-semiconductor (CMOS) logic circuits. To explore the limits of this technology in extreme environments, here we study total ionizing dose (TID) effects in enhancement-mode SWCNT-CMOS inverters that employ organic doping and encapsulation layers. Details of the evolution of the device transport properties are revealed by in situ and in operando measurements, identifying n-type transistors as the more TID-sensitive component of the CMOS system with over an order of magnitude larger degradation of the static power dissipation. To further improve device stability, radiation-hardening approaches are explored, resulting in the observation that SWNCT-CMOS circuits are TID-hard under dynamic bias operation. Overall, this work reveals conditions under which SWCNTs can be employed for radiation-hard integrated circuits, thus presenting significant potential for next-generation satellite and space applications.
<title>Packaging for 3D optoelectronic stacked processors</title> (1999)

The performance requirements of computer, telecommunication, and data-communication systems have increased considerably in recent years to a point where large-scale electronic systems nov suffer from an interconnection bottleneck Large computational systems, with tens, hundreds, or more nodes: are composed of many chip-to-chip and/or module-tomodule interconnections. These complex interconnection systems must be efficient and fast for good overall system performance. Free-space optical interconnects (FSOI) when combined with electronics offer a potential solution to relieve this communication bottleneck 4.5,6,7.8,9,10,11 Indeed, FSOI offer advantages in terms of large interconnection density, high distance-bandwidth product, low power dissipation, and superior crosstalk performance, especially at high data rates. 2,13.14,15,16 However, packaging of FSOI has become one of the major issues, in which alignment is the key factor determining the feasibility and performance of the whole system 17,18.19.20 Critical advances are required to assemble optoelectronic and optical components in a rugged yet simple system fully compatible with conventional electronic packages. In the following sections, we present how a conventional PCB board is populated with optoelectronic detector and laser chips and mated to an FSOI layer that is assembled separately. This is achieved using only commercially available devices and services and enabled b means of simple passive alignment techniques. Design considerations, system simulations, as well as experimental results are presented.
Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy (2016)

Multiple System Atrophy (MSA) is a sporadic neurodegenerative disorder characterized by parkinsonism, cerebellar ataxia and dysautonomia, in various combinations. In MSA with parkinsonism (MSA-P), the degeneration is mainly restricted to the substantia nigra pars compacta and putamen. Studies have identified alterations in DJ-1 (PARK7), a key component of the anti-oxidative stress response, in Parkinson's disease (PD) and MSA patients. Previously we have shown that a short DJ-1-based peptide named ND-13, protected cultured cells against neurotoxic insults and improved behavioral outcome in animal models of Parkinson's disease (PD). In this study, we used the 3-Nitropropionic acid (3-NP)-induced mouse model of MSA and treated the animals with ND-13 in order to evaluate its therapeutic effects. Our results show that ND-13 protects cultured cells against oxidative stress generated by the mitochondrial inhibitor, 3-NP. Moreover, we show that ND-13 attenuates nigrostriatal degeneration and improves performance in motor-related behavioral tasks in 3-NP-treated mice. Our findings suggest a rationale for using ND-13 as a promising therapeutic approach for treatment of MSA.
Parameterized surrogate models of broadband passive electronic components (2012)

A self-organizing sampling and modeling algorithm is presented for building compact multivariate surrogate models of general passive electronic components.The algorithm builds compact analytical circuit models and represents the scattering parameters of the passive components as a function of its geometrical parameters and as a function of the frequency.The model generation algorithm combines iterative sampling and modeling techniques.It groups a number of full-wave electromagnetic (EM) simulations in one multivariate analytic model.The analytical surrogate circuit models can easily be implemented and used in commercial circuit simulators.The compact models combine EM-accuracy and generality, with circuit simulation speed and flexibility.
Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. (2002)

HPV-16 infection and integration is seldom found in oral premalignant lesions and invasive carcinoma, and therefore rarely contributes to malignant progression in the oral cavity. Furthermore, quantitative PCR is a useful technique that reliably excludes contaminated samples and those with minimal HPV DNA content that is unlikely to be significant in carcinogenesis.
Refrigeration technologies for sub-ambient temperature operation of computing systems (2002)

Thermal management issues are central to development of computing systems in the next millennium. In light of performance and reliability limitations facing scaling of CMOS devices below 100 nm channel lengths at typical operating temperatures (60-100/spl deg/C), many system designers are seriously considering low temperature operation of high performance processors. Two different refrigeration technologies being developed for server applications are described here.
Tri-Band PCB Antenna for Wireless Sensor Network Transceivers in Home Automation Applications (2012)

A novel tri-band antenna design for wireless sensor network devices in home automation applications is proposed. The design is based on a combination of a conventional monopole wire antenna and discrete distributed load impedances. The load impedances are employed to ensure the degrees of freedom necessary to obtain a simultaneous optimization of input impedance and current distribution on the antenna structure. A transmission line model is presented together with 3D finite-element simulation results and measurements on the physical antenna.
Measurement of thet-Channel Single Top Quark Production Cross Section inppCollisions ats=7  TeV (2011)

Electroweak production of the top quark is measured for the first time in pp collisions at √=7 TeV, using a data set collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 pb⁻¹. With an event selection optimized for t-channel production, two complementary analyses are performed. The first one exploits the special angular properties of the signal, together with background estimates from the data. The second approach uses a multivariate analysis technique to probe the compatibility with signal topology expected from electroweak top-quark production. The combined measurement of the cross section is 83.6±29.8(stat+syst)±3.3(lumi) pb, consistent with the standard model expectation.
Comparative Analysis of Surgical Approaches and Osteotomies for the Correction of Sagittal Plane Spinal Deformity in Adults (2012)

A posterior-only or combined surgical approach had comparable radiographical outcomes. Higher morbidity was significant in regard to operative time in the combined-approach group. Deciding on the approach best suited for achieving correction in the sagittal plane likely resides on the surgeon's experience and expertise.
Supplementary Figure 1 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors (2023)

&lt;p&gt;Supplementary Figure 1: Visual depiction of the proportion of patients with at least 1 mosaic chromosomal alteration&lt;/p&gt;
Semiconductor quantum plasmons for high frequency thermal emission (2020)

Abstract Plasmons in heavily doped semiconductor layers are optically active excitations with sharp resonances in the 5–15 μm wavelength region set by the doping level and the effective mass. Here, we demonstrate that volume plasmons can form in doped layers of widths of hundreds of nanometers, without the need of potential barrier for electronic confinement. Their strong interaction with light makes them perfect absorbers and therefore suitable for incandescent emission. Moreover, by injecting microwave current in the doped layer, we can modulate the temperature of the electron gas. We have fabricated devices for high frequency thermal emission and measured incandescent emission up to 50 MHz, limited by the cutoff of our detector. The frequency‐dependent thermal emission is very well reproduced by our theoretical model that let us envision a frequency cutoff in the tens of GHz.
Experimental Evaluation of the Laser Assisted Machining of Silicon Nitride Ceramics (1999)

To assess the feasibility of the laser assisted machining (LAM) process for the machining of difficult-to-machine materials such as structural ceramics, experiments were performed on silicon nitride workpieces for a wide range of operating conditions. Data for cutting forces and surface temperatures indicate that the lower bound of the material removal temperature for avoidance of cutting tool and/or workpiece fracture corresponds to the YSiAlON glass transition temperature (920–970°C). As temperatures near the cutting tool increase to values above the glass transition temperature, the glassy phase softens, facilitating visco-plastic flow and, correspondingly, the production of semi-continuous or continuous chips. The silicon nitride workpiece machined had a surface roughness of Ra=0.39 μm at the nominal LAM operating condition. Examination of the machined surfaces and chips reveals no detectable sub-surface cracking or significant changes in microstructure, respectively. Relative to grinding, the most significant advantage of LAM is its ability to achieve much larger material removal rates with high workpiece surface quality and reasonable levels of tool wear. [S1087-1357(00)00704-8]
Determination of population, alignment, and orientation using laser induced fluorescence with unresolved emission. II (1989)

When an anisotropic ensemble of isolated atoms or molecules absorbs radiation from a polarized laser beam and the resulting fluorescence is collected independent of wavelength (1+1 unresolved LIF) with optional polarization analysis, the moments of the spatial distribution of the angular momentum J of the initial state in the ensemble may be determined. Previously, work by A. C. Kummel, G. O. Sitz, and R. N. Zare [J. Chem. Phys. 88, 7357 (1988)] correctly derived what possible moments can be found when cylindrical symmetry is present. This work shows that several additional alignment moments, not mentioned in KSZ, can be found in ensembles having noncylindrical symmetry.