gebhart/patrepeval huggingface dataset:
Automated modeling of complex data center applications (2013)

As online services become increasingly common, the complexity of backend distributed server applications in data centers has also continued to grow. At the same time, there is an increasing need to enhance the manageability of these large applications by automating common management tasks, which requires a good understanding of the run-time behavior of the application under different scenarios. However, the rising complexity of these applications makes the tasks of manually modeling and analyzing their run-time behavior increasingly difficult. In this talk, I will argue for the need to automate the modeling of the run-time performance of distributed data center applications. I will present techniques for automatically deriving application models using statistical methods from machine learning. I will describe how we have put these ideas into practice into two systems that we have built, Modellus and Predico, and will present case studies of using these systems for management tasks such as capacity planning and what-if analysis of data center applications.
A two-stage acquisition scheme based on multiple correlator outputs for UWB signals (2011)

In ultra-wideband (UWB) channels, the signal energy in the acquisition receiver spreads over correlator outputs due to rich multipaths, making the output of each correlator have only a small portion of the total energy. To enhance the acquisition performance for UWB signals by exploiting the signals spread over a number of correlator outputs, this paper proposes a two-stage acquisition scheme. In the proposed scheme, decision variables are formed by combining a multiple of correlator outputs, allowing it possible to make use of the signal energy spread over the outputs jointly. Simulation results show that the proposed scheme can provide a gain of about 0.6dB over the conventional schemes in various UWB channel environments.
Comparative Study of Inflow Conditions for Spatially Evolving Simulation (1997)

A new spatiotemporal inflow condition is devised and evaluated with other methods, i.e., temporal, phase jittering and amplitude jittering, and random noise. These methods are validated by testing a large-eddy simulation of turbulent channel flow. Computational results are presented to disclose the ability of inflow conditions to capture the turbulent statistics with correct phase information and dynamics. The present spatiotemporal inflow condition is found to be generally satisfactory in CPU time and data management.
Reconstitution of the Functional lnterleukin-5 Receptor: The Cytoplasmic Domain of Alpha-Subunit Plays an Important Role in Growth Signal Transduction (1994)

The receptor for interleukin-5 (IL-5) is composed of two distinct subunits, alpha and beta. The cDNAs that encode the mouse and human alpha-subunit were transfected into the mouse IL-3-dependent cell line, FDC-P1 expressing the mouse beta-chain intrinsically. The resulting transfectants became responsive to human and mouse IL-5, respectively. Using the mutant alpha-subunits, we found that the alpha-subunit as well as the beta-subunit participated in IL-5-mediated growth signal transduction. The FDC-P1 transfectants expressing the alpha-subunit which lacks its whole cytoplasmic domain did not respond to IL-5, though the interaction of the mutant alpha- and beta-subunits was not impaired. The transfectants expressing the alpha-subunit which lacks the C-terminal half of its cytoplasmic domain proliferated in the presence of IL-5. These results indicate that the transmembrane-proximal cytoplasmic portion of the alpha-subunit plays an important role in IL-5-mediated growth signal transduction.
Load Forecasting of Privacy-Aware Consumers (2019)

The roll-out of smart meters (SMs) in the electric grid has enabled data-driven grid management and planning techniques. SM data can be used together with short-term load forecasts (STLFs) to overcome polling frequency constraints for better grid management. However, the use of SMs that report consumption data at high spatial and temporal resolutions entails consumer privacy risks, motivating work in protecting consumer privacy. The impact of privacy protection schemes on STLF accuracy is not well studied, especially for smaller aggregations of consumers, whose load profiles are subject to more volatility and are, thus, harder to predict. In this paper, we analyse the impact of two user demand shaping privacy protection schemes, model-distribution predictive control (MDPC) and load-levelling, on STLF accuracy. Support vector regression is used to predict the load profiles at different consumer aggregation levels. Results indicate that, while the MDPC algorithm marginally affects forecast accuracy for smaller consumer aggregations, this diminishes at higher aggregation levels. More importantly, the load-levelling scheme significantly improves STLF accuracy as it smoothens out the grid visible consumer load profile.
Projective rectification-based view interpolation for multiview video coding and free viewpoint generation (2009)

A projective rectification-based view interpolation algorithm is developed for multiview video coding and free viewpoint video. It first calculates the fundamental matrix between two views without using any camera parameter. The two views are then resampled to have horizontal and matched epipolar lines. One-dimensional disparity is estimated next, which is used to interpolate the image for an intermediate viewpoint. After unrectification, the interpolated view can be displayed directly for free viewpoint video purpose. It can also be used as a reference to encode data of an intermediate camera. Experimental results show that the interpolated views can be 3 dB better than existing method. Video coding results illustrate that the method can provide up to 1.3 dB improvement over JMVC.
Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. (1995)

In vitro studies indicate that muscarinic cholinergic inhibition of beta-adrenergic cardiac responses may be modulated in part by nitric oxide (NO). To evaluate the role of NO in parasympathetic inhibition of the beta-adrenergic contractile response in vivo, we assessed the inotropic response to dobutamine before and during bilateral vagus nerve stimulation in closed-chest dogs. Dobutamine administration and vagal stimulation were repeated during intracoronary infusion of the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA, 10 mumol/min) and again following infusion of L-arginine (100 mg/kg). In eight dogs, intracoronary dobutamine infusion at rates of 25 and 50 micrograms/min increased peak +dP/dt by 131 +/- 24 and 168 +/- 22%, respectively (P < 0.0001). Vagal stimulation (2.5 Hz) attenuated the responses to dobutamine (25 and 50 micrograms/min) by 23 +/- 4 and 21 +/- 4%, respectively (P < 0.001). L-NMMA reduced (by 44-62%; P < 0.001) and L-arginine restored vagal inhibition of the dobutamine-stimulated inotropic response. In a second group of nine dogs, dobutamine was administered systemically to assure a constant concentration in the coronary circulation. Vagal stimulation (2.5 Hz) attenuated the dobutamine-stimulated inotropic response (2.5 and 5.0 micrograms/kg per min) by 40 +/- 12% and 57 +/- 8%, respectively (P < 0.004). As with intracoronary dobutamine, L-NMMA diminished and L-arginine restored vagal inhibition of the inotropic response to dobutamine. Intracoronary infusion of atropine (12 micrograms/min) abolished the vagal inhibitory effect, and intracoronary infusion of 8-bromo-cyclic GMP (1 and 10 mM) caused a dose-dependent attenuation of the dobutamine-stimulated increase in +dP/dt. These data suggest that NO mediates, at least in part, vagal inhibition of the inotropic response to beta-adrenergic stimulation by dobutamine, and thus may play a role in normal physiologic regulation of myocardial autonomic responses.
Foundation Design for High Tension Cable Guardrails (2010)

High tension cable guardrail is becoming increasing popular in median and roadside applications due to the promise of reduced deflections upon impact and reduced maintenance. As the performance of these systems is observed in service, there is a growing concern over the end anchorage foundation performance of current systems. Foundations for high tension systems must not only be capable of restraining the impact load of a vehicle but must also restrain the initial pretension on the cable system as well as temperature induced loads. While it may be acceptable for many roadside safety devices to require foundation repair after impact, foundation failure due to environmentally induced loads would be a serious maintenance problem. As initial tension and temperature induced loads can be greater than those loads applied during impact, this type of loading must be considered in foundation design. Foundation deflection can reduce cable tension, increasing deflection of the system during impact and letting the cables sag after impact. The soil conditions in which these foundations are placed vary significantly. This report considers the potential impact, tension, and temperature loads and develops a set of suggested foundation designs to accommodate a range of in situ soil conditions. These designs will vary significantly in different areas around the nation due to variations in both weather and in situ soil conditions. Deflection during full-scale crash tests may not accurately represent the foundation deflection that will be experienced in the field.
Biomechanical and Biochemical Cellular Response Due to Shock Waves (2008)

Our research provides a first step towards a systematic, cell-level study of the effects of shock waves on the mechanical and biochemical properties of cells on solid supports. Motivated to better understand the relationship between shock exposure and heterotopic ossification (HO) a type of soft tissue injury, we designed an experimental setup to expose cell sheets of adipose derived stem cells to shock waves. A key guideline in the experimental design was to suppress cavitation. To this end we built a spark transducer and used a pressurized sample chamber. Cell viability tests and cytoskeletal staining showed little difference between shock-exposed cells and controls. We attribute this to the absence of cavitation. Time-resolved gene expression revealed that a large number of genes were affected by the shock wave exposure. Importantly, the experimental setup and the procedures we developed provide a basis for further studies of shock wave effects on a broad range of other cells. Specifically, they could be adopted to gain further understanding of cellular level causes of traumatic brain injury. 1.
Room-temperature preparation of β-FeSi2 microprecipitates by the KrF excimer laser ablation of an iron disilicide alloy target (2003)

We have fabricated β-FeSi2 microprecipitates at room temperature using KrF excimer laser ablation of an α-FeSi2 alloy target. Raman spectra with a spatial resolution of 1 μm confirmed that the micron-sized droplets generated by laser ablation precipitate as the β-FeSi2 crystalline phase on a silicon substrate maintained at RT, whereas the rest of the deposited film is amorphous. It was also found that films containing a high density of β-FeSi2 precipitates exhibited 1.55 μm photoluminescence at low temperature (up to 200 K) after annealing at 800 °C for 6 h in an argon atmosphere.
Functional heterogeneity of nociceptin/orphanin FQ receptors revealed by (+)-5a Compound and Ro 64-6198 in rat periaqueductal grey slices (2010)

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a non-opioid branch of the opioid receptor family implicated in several neurological and psychological disorders, such as pain, anxiety, depression, involuntary movement, addiction, seizure and dementia. Heterogeneity of NOP receptors has been proposed based on the findings of splicing variants and from binding and functional studies. We have previously reported that Ro 64-6198, a NOP receptor agonist, activated a subset, but not all, of N/OFQ-sensitive NOP receptors in midbrain ventrolateral periaqueductal grey (vlPAG). In this study, we found that a new NOP receptor ligand, (+)-5a Compound ((3aS, 6aR)-1-(cis-4-isopropylcyclohexyl)-5'-methyl-2'-phenylhexahydrospiro[piperidine-4,1'-pyrrolo[3, 4-c]pyrrole]), also activated a subset of NOP receptors in vlPAG neurons. (+)-5a Compound (0.1-30 μm) concentration-dependently activated G-protein-coupled inwardly-rectifying potassium (GIRK) channels mediated through the NOP receptors in about 35% of the recorded vlPAG neurons. (+)-5a Compound (EC50: 605 nm) was less potent (1/12) and efficacious (47%) than N/OFQ. In (+)-5a Compound-insensitive neurons, Ro 64-6198 was also ineffective, and vice versa, but N/OFQ activated GIRK channels through NOP receptors. In (+)-5a Compound-sensitive neurons, (+)-5a Compound precluded the effect of Ro 64-6198. Immunofluorecent and morphometric studies showed that most of the (+)-5a Compound-sensitive neurons were multipolar with intensive dendritic arborization and immunoreactive to glutamic acid decarboxylase-67. It is suggested that (+)-5a Compound activates a subset of NOP receptors, similar to the Ro 64-6198-sensitive subset, in the vlPAG neurons which are mostly GABAergic. These results further support the presence of functional heterogeneity of NOP receptors in the midbrain PAG.
Quantitative Driving Style Estimation for Energy-Oriented Applications in Road Vehicles (2013)

Energy-consumption in ground transportation systems is a major cause of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> emissions and related environmental concerns. A relevant part of such an energy use can be saved by devising systems that can help promoting an economical driving style. To address this challenging issue, this paper presents a method and system that allow providing a quantitative description the driving style and illustrating it to the driver by means of real time visual feedback. The driving style assessment is based on the definition of appropriate energy-oriented cost functions that can be evaluated based on inertial measurements only, thereby providing a vehicle-independent methodology. The effectiveness of the approach, and the savings enabled by the interaction with the driver are assessed with an experimental campaign carried out on urban and extra-urban routes by different drivers.
Binary systemforregulating transgene expression inmice: Targeting int-2 geneexpression withyeast GAL4/UAS control elements (1991)

ABSTRACT Wehavedeveloped a binary transgenic sys-temthatactivatesanotherwisesilenttransgeneintheprogenyofasimple genetic cross. Thesystemconsists oftwo types oftransgenicmousestrains, targetsandtransactivators. Atargetstrain bears a transgene controlled by yeast regulatory se-quences (UAS) that respond only to the yeast transcriptionalactivator GALA. Atransactivator strain expresses an activeGAL4gene that canbedriven byany selected promoter. The current paradigm uses the murinegrowth factor int-2 cDNA as the target gene and the GAL4gene driven by the mousemammary tumorvirus long terminal repeat as the transacti-vator. Both target and transactivator strains are phenotypi- cally normal. Bycontrast, the bigenic offspring ofthese two strainsexpresshighlevels ofthe target int-2 gene in eachorganexpressing the GAL4transactivator. They also display achar-acteristic dominant int-2 phenotype that consists of epithelialhyperplasia in mammary and salivary glands, as well as prostatic andepididymal hypertrophy, which results
Hodgkin's Lymphoma in Adolescents Treated With Adult Protocols: A Report From the German Hodgkin Study Group (2009)

PURPOSE The standard of care for adolescent patients with Hodgkin's lymphoma (HL) is undefined, particularly the choice between pediatric and adult protocols. Thus, we compared risk factors and outcome of adolescents and young adults treated within study protocols of the German Hodgkin Study Group (GHSG). PATIENTS AND METHODS Three thousand seven hundred eighty-five patients treated within the GHSG studies HD4 to HD9 were analyzed; 557 patients were adolescents age 15 to 20 years, and 3,228 patients were young adults age 21 to 45 years. Results Large mediastinal mass and involvement of three or more lymph node areas were more frequent in adolescents (P < .001). The incidence of other risk factors did not differ significantly between age groups. With a median observation time of 81 months for freedom from treatment failure (FFTF) and 85 months for overall survival (OS), log-rank test showed no significant differences between age groups regarding FFTF (P = .305) and a superior OS (P = .008) for adolescents. Six-year estimates for FFTF and OS were 80% and 94%, respectively, for adolescents and 80% and 91%, respectively, for young adults. After adjustment for other predictive factors, Cox regression analysis revealed age as a significant predictor for OS (P = .004), with a higher mortality risk for young adults. Secondary malignancies were more common in young adults (P = .037). CONCLUSION Outcome of adolescent and young adult patients treated within GHSG study protocols is comparable. These data suggest that adult treatment protocols exhibit a safe and effective treatment option for adolescent patients with HL. However, longer follow-up, including assessment of late toxicity, is necessary for final conclusions.
Dynamics of bicontinuous microemulsion phases with and without amphiphilic block-copolymers (2001)

Neutron Spin Echo and Dynamic Light Scattering techniques are used for an extensive investigation of the bicontinuous phase in water/decane microemulsions. The dynamical behavior of different surfactant systems, decyl polyglycol ether (C10E4), C10E4 mixed with polyethylenepropylene/polyethyleneoxide amphiphilic block-copolymers-(PEPx/PEOy), and sodium-bisethylhexylsulfosuccinate (AOT) is investigated under comparable conditions. At scattering wave numbers q large compared to the inverse of the structure length scale, q0=2π/d, always stretched exponential relaxations ∝e−(Γqt)β with Γq∝q3 are found, as predicted theoretically. The relaxation rate increases almost linearly as function of the bicontinuous structure correlation scale—ξ≃d/2. The apparent bare bending modulus κ determined by fitting theoretical predictions to the experimental high-q data yields values of about 1.3kBT—as inferred from previous small angle neutron scattering (SANS) studies and from other methods. The effect of increasing rigidity of the surfactant layers by anchoring amphiphilic block-copolymers, predicted theoretically and revealed experimentally in structural investigations, could not be clearly resolved due to its small influence on the dynamics. At structural length scales, the relaxation rate in water–oil contrast shows a minimum corresponding to the maximum of the static structure factor. At length scales much larger than the typical structure length the relaxation is single-exponential with a q2 dependent rate. In this regime we find indications of the additional membrane interaction due to the presence of block-copolymers.
Biochemical Characterization of the Wheat Waxy A Protein and Its Effect on Starch Properties (1999)

ABSTRACT Granule bound starch synthase1 (GBSS1) is a key enzyme in amylose biosynthesis and is encoded by the A, B and D GBSS1 wx loci in wheat. Wheat lines with mutations at the three GBSS1 loci have been identified. We have characterized and compared the grain starch of CDCW6 wheat line (null B and D for GBSS1) with PI235238 (null A and B for GBSS1), waxy (null A, B and D for GBSS1), and AC Reed (wild type wheat) grain starches. The grain starch of waxy, CDCW6, PI235238, and AC Reed lines contained ≈0, 12, 23, and 25% amylose (w/w), respectively. Waxy, partially waxy, and wild wheat grain starches showed significant differences in onset and peak transition temperatures as determined by differential scanning calorimetric analysis. Grain starches extracted from waxy, CDCW6, and PI235238 also had higher enthalpy of gelatinization values than did wild wheat starch. X‐ray diffraction analysis revealed the highest crystallinity for starch extracted from waxy wheat, followed by CDCW6. The starch produced from the CDCW6 line may find special food and industrial applications because of its relatively low amylose concentration.
Frontiers in bronchoscopic imaging (2011)

Bronchoscopy is a minimally invasive method for diagnosis of diseases of the airways and the lung parenchyma. Standard bronchoscopy uses the reflectance/scattering properties of white light from tissue to examine the macroscopic appearance of airways. It does not exploit the full spectrum of the optical properties of bronchial tissues. Advances in optical imaging such as optical coherence tomography (OCT), confocal endomicroscopy, autofluorescence imaging and laser Raman spectroscopy are at the forefront to allow in vivo high-resolution probing of the microscopic structure, biochemical compositions and even molecular alterations in disease states. OCT can visualize cellular and extracellular structures at and below the tissue surface with near histological resolution, as well as to provide three-dimensional imaging of the airways. Cellular and subcellular imaging can be achieved using confocal endomicroscopy or endocytoscopy. Contrast associated with light absorption by haemoglobin can be used to highlight changes in microvascular structures in the subepithelium using narrow-band imaging. Blood vessels in the peribronchial space can be displayed using Doppler OCT. Biochemical compositions can be analysed with laser Raman spectroscopy, autofluorescence or multispectral imaging. Clinically, autofluorescence and narrow-band imaging have been found to be useful for localization of preneoplastic and neoplastic bronchial lesions. OCT can differentiate carcinoma in situ versus microinvasive cancer. Endoscopic optical imaging is a promising technology that can expand the horizon for studying the pathogenesis and progression of airway diseases such as COPD and asthma, as well as to evaluate the effect of novel therapy.
Study of Surface Morphology, Impurity Incorporation and Defect Generation during Homoepitaxial Growth of 4H-SiC Using Dichlorosilane (2014)

The growth of 4° off-axis 4H-SiC epilayers by chemical vapor deposition is studied using dichlorosilane as the Si precursor in a chimney reactor. The unintentional and intentional nitrogen doping at various C/Si ratios and N2 flow rates are investigated. The C/Si ratio has a significant influence on the growth rate, surface morphology, conversion of basal plane dislocations (BPDs), and generation of other defects (e.g., in-growth stacking faults and morphological defects). Addition of N2 has no obvious influence on growth rate and BPD conversion. It is preferable to grow high quality n+ epilayers at a C/Si ratio in the range of 1.3–1.8 along with the addition of a suitable amount of N2 in consideration of high growth rate, good surface morphology, and low defect density. In this case, the conversion ratio of BPDs to threading edge dislocations is greater than 99.8% regardless of N2 addition. Therefore >99.8% substrate BPDs can be buried in an n+ buffer layer, which is beneficial to SiC bipolar power devices. No special treatment prior to, during or after the epigrowth is necessary. The epilayers with doping concentration all the way from p− (∼1e15 cm−3) to semi-insulating, then to n+ (∼1e18 cm−3), can be achieved, giving a great range of flexibility in growth using dichlorosilane precursor. Further optimization of in-situ etching and growth conditions to eliminate step bunching has also been suggested.