gebhart/patrepeval huggingface dataset:
Estimation of the second crossover in insulators using the electrostatic mirror in the scanning electron microscope (1997)

A technique for measuring the second secondary emission crossover in insulators was developed. The method utilizes the behavior of an electrostatic mirror formed on insulating samples to estimate the current equilibrium point as well as the mirror potential. Current results show that the value of the second crossover for glass passivation obtained using this method is in general agreement with previous techniques.
Nanoscale Porous Framework of Lithium Titanate for Ultrafast Lithium Insertion (2012)

Mesoporöses Lithiumtitanat wurde hergestellt, das die Titanatmorphologie für die schnellste Lithium-Insertion darstellt. Das Material zeigt eine gravimetrische Kapazität von 175 mA h g−1 und kann bis zu 73 % der Maximalkapazität mit bis zu 800 C (4.5 s) in über 1000 stabilen Zyklen bereitstellen. Ein Schlüsselmerkmal ist die vollständig kristalline vernetzte poröse Gerüststruktur bestehend aus nur wenige nm großen Spinell-Nanokristallen. Skalierung: 10 nm.
Special issue on computational image sensors and smart camera hardware (2017)

Authors from academia and industry working in the above or closely related research areas are requested to submit original manuscripts that have not been published previously and are not currently under review in other journals or conferences. All manuscripts must be electronically submitted through IJCTA Manuscript Central Website, https://mc.manuscriptcentral.com/ijcta. Indicate that you are submitting your article to the special issue on ‘Computational Image Sensors and Smart Camera Hardware’. Please, visit IJCTA website for detailed author guidelines: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-007X/homepage/ForAuthors.html Paper submission: September 30, 2017. Publication date: September, 2018. Guest Editors
Strong selection during the last millennium for African ancestry in the admixed population of Madagascar (2018)

While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history.
Biomechanics of unilateral compared with bilateral lumbar pedicle screw fixation for stabilization of unilateral vertebral disease (2008)

Unilateral fixation is inadequate for stabilizing a 2-level unilateral lesion. Bilateral fixation, whether symmetrical or asymmetrical, provides good stabilization for this injury. It is not important for stability to include the level of the lesion within the long construct contralaterally.
A 6-DoF Position Sensor for Bearingless Slice Motors (2023)

This paper describes a position sensor with six degrees of freedom (DoF) measurement capability. This sensor is designed for the position sensing of the rotor in a bearingless slice motor to enable active control. The sensor is designed to fit entirely under the rotor and operates by accessing the rotor bottom surface only, enabling packaging of the pump on the top of the rotor. The sensor has two parts; both operate using eddy currents. One of these parts measures the two radial DoF of the rotor. The other part measures the axial, angular rotation and tip/tilt DoF. The sensor utilizes a conductive target fixed to the underside of the rotor. Motion of this target varies the magnetic fields which can then be measured by the sensor as variation in either induced voltage or inductance value. The design and fabrication of the sensor along with the signal processing methods are presented in detail. The radial position measurements are the most critical for active levitation due to the small working gaps in these DoF, hence a resolution of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo><</mml:mo> <mml:mn>1.2</mml:mn> <mml:mtext>​</mml:mtext> <mml:mo> </mml:mo> <mml:mi>μ</mml:mi> <mml:mtext>m</mml:mtext></mml:mrow> </mml:math> and bandwidth of 1 kHz is achieved. This paper also describes the closed-loop behavior of a bearingless motor using this sensor.
Favorable Immune Signature in CLL Patients, Defined By Antigen-Specific T-Cell Responses, Might Prevent Secondary Skin Cancers (2015)

Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. The course of disease predisposes patients to the development of secondary malignancies, which might be due to a generalized immunosuppression induced by the disease and/or the therapies used for treatment. Skin cancer, including melanoma, is the most common secondary malignancy reported in these patients. In a recent study we reported on spontaneous memory T cell responses against CLL-associated antigens defined by HLA ligandome analysis in CLL patients. Moreover, retrospective analysis suggests a significant survival benefit for CLL patients showing immune reactions to more than one of the tested antigens (Kowalewski et. al., PNAS 2015). Here we analyzed our CLL patient cohort for the incidence of secondary malignancies, and in particular for skin cancers. A total of 15 CLL-associated HLA-peptides (6 A*02, 3 A*03, 6 B*07) were implemented for stimulation of HLA-matched PBMC obtained from CLL patients. 45 CLL patients (Binet A n=15, Binet B, n=15, Binet C n=15, median age, 33.3% (15/45) with prior CLL specific therapy) were analyzed for antigen-specific memory T-cell responses in IFNγ-ELISPOT assays. 13 patients (28.9%, response cohort) showed specific T cell response against &gt; 1 antigen, while 32 patients (71.1%, negative cohort) showed none or only one immune response. The median age was 71 in the response cohort and 73 in the negative cohort. 40.0% (6/15) of CLL patients with Binet stage A and 33.3% (5/15) with stage B were classified as responders whereas only 13.3% (2/15) of patients with stage C showed &gt;1 immune responses. Of the included CLL patients with prior therapy only one patient (8%) showed &gt; 1 immune responses. In the analyzed CLL patient cohort 7 skin cancers (melanoma: n=2, squamous cell carcinoma: n=2, basal cell carcinoma: n=3), 3 precancerous skin lesions and 9 other secondary malignancies including renal cell carcinoma (n=2), colon (n=3), breast (n=2) and prostate cancer (n=2) were observed. In the negative cohort 34.4% (11/32) of the patients developed a secondary malignancy, while only 15.4% (2/13) in the immune response cohort presented with secondary neoplasms. Strikingly all skin cancers and precancerous skin lesions were observed in the non-immune responder cohort. Furthermore multiple secondary malignancies (e.g. squamous cell carcinoma and colon cancer) were only observed in the cohort that showed no immune response. Taken together our data suggest that a favorable immune signature in CLL patients, i.e. the ability to mount T-cell responses against CLL-associated antigens not only is associated with improved overall survival but also might protect these patients from the development of secondary skin cancers. Disclosures No relevant conflicts of interest to declare.
Enzymatic bioremediation of chemical pesticides (2001)

Enzyme-based bioremediation technologies are potentially capable of\nqualitatively quicker action than traditional microbial bioremediation\nprocesses. This in turn qualitatively expands their potential\napplications. CSIRO and Orica Australia are developing an enzyme\ntechnology for remediating pesticide residues in applications as\ndiverse as waste irrigation waters, surface contaminated fruit and\nvegetables, and spent dip liquors for a variety of agricultural\nproductions and processing industries. Effective and affordable\nremediation under these circumstances requires some highly specialised\nenzymes. However early trials on the team's first organophosphate\ndegrading enzyme have shown it is feasible to achieve remediation in\nsuch circumstances.
Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices (2016)

Right heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the in vitro test bench, which simulates the hemodynamic behavior of the native circulatory system. To model healthy and diseased arterial-pulmonary hemodynamics in adults (mild and severe PH and RHF), a right heart mock circulation loop (MCL) was developed. Incorporating an anatomically shaped silicone RV and a silicone atrium, it not only enables investigations of hemodynamic values but also suction events or the handling of minimal invasive RVADs in an anatomical test environment. Ventricular pressure-volume loops of all simulated conditions as well as pressure and volume waveforms were recorded and compared to literature data. In an exemplary test, an RVAD was connected to the apex to further test the feasibility of studying such devices with the developed MCL. In conclusion, the hemodynamic behavior of the native system was well reproduced by the developed MCL, which is a useful basis for future RVAD tests.
The X'tal cube PET detector of isotropic (0.8 mm)3 crystal segments (2014)

Depth-of-interaction measurement is essential for PET to reduce the parallax error, resulting in improved spatial resolution with maintaining sensitivity. One of ultimate goals of improvement in DOI detectors is achieving isotopic spatial resolution. For this purpose, we have developed an isotropic 3D position sensitive PET detector named X'tal cube. The X'tal cube is composed of a scintillation crystal block segmented into cubes. Arrays of multi pixel photon detectors (MPPCs) cover all surfaces of the crystal block. In our previous study, we achieved 1.0 mm isotropic spatial resolution. In this study, we finally succeeded to develop the X'tal cube with (0.8 mm) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> isotropic segments. The scintillation crystal block was a 13.6 × 13.6 × 13.6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> monolithic LYSO. 3D segmentation of 17 × 17 × 17 array of 0.8 mm × 0.8 mm × 0.8 mm grids was made by the laser processing. We used 96 MPPCs (S12642-0404PB-50(X)). For each face of the crystal block, monolithic 4 × 4 array of MPPCs with about 0.2 mm gaps was coupled. The position histograms were made by the 3D Anger-type calculation from uniform irradiation data, which showed good identification of each segments. We obtained 9.0% energy resolution for the central part of the crystal block. In conclusion, we succeeded to develop a prototype PET detector with the world's finest segments of (0.8 mm) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> grids.
IRW (2002)

We present a new representation for image-based interactive walk-throughs. The target applications reconstruct a scene from novel viewpoints using samples from a spatial image dataset collected from a plane at eye-level. These datasets consist of pose augmented 2D images and often have a very large number of samples. Our representation exploits spatial coherence and rearranges the input samples as epipolar images. The base unit corresponds to a column of the original image that can be individually addressed and accessed. The overall representation, IRW, supports incremental updates, efficient encoding, scalable performance, and selective inclusion used by different reconstruction algorithms. We demonstrate the performance of our representation on a synthetic as well as a real-world environment.
Heterologous Expression of a Trypanosoma cruzi Surface Glycoprotein (gp82) Indicates that Requirements for Glycosylphosphatidylinositol Anchoring are Different in Mammalian Cells and this Trypanosome (1999)

Made available in DSpace on 2015-06-14T13:24:54Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-07-01. Added 1 bitstream(s) on 2015-08-11T03:59:16Z : No. of bitstreams: 1 S0074-02761999000400018.pdf: 182080 bytes, checksum: 2df2937761b692d57315c335baa7723c (MD5)
Crystal structure ofN-(3-oxobutanoyl)-L-homoserine lactone (2016)

The structure and absolute configuration of the title compound, C8H11NO4, which is a known quorum-sensing modulator, have been determined. The mol-ecule exhibits signs of an intra-molecular attractive carbon-yl-carbonyl n→π* inter-action between the amide and lactone ester groups, specifically - a short contact of 2.709 (2) Å between the amide oxygen atom and ester carbon atom, approach of the amide oxygen atom to the ester carbonyl group along the Bürgi-Dunitz trajectory, at 99.1 (1)°, and pyramidalization of the ester carbonyl group by 1.1 (1)°. Moreover, a similar n→π* inter-action is observed for the amide carbonyl group approached by the ketone oxygen donor. These inter-actions apparently affect the conformation of the uncomplexed mol-ecule, which adopts a different shape when bound to protein receptors. In the crystal, the mol-ecules form translational chains along the a axis via N-H⋯O hydrogen bonds.
Monodisperse InAs Quantum Dots from Aminoarsine Precursors: Understanding the Role of Reducing Agent (2018)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMonodisperse InAs Quantum Dots from Aminoarsine Precursors: Understanding the Role of Reducing AgentVishwas SrivastavaVishwas SrivastavaDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, United StatesMore by Vishwas Srivastava, Eleanor DunietzEleanor DunietzDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, United StatesMore by Eleanor Dunietz, Vladislav KamysbayevVladislav KamysbayevDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, United StatesMore by Vladislav Kamysbayev, John S. AndersonJohn S. AndersonDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, United StatesMore by John S. Andersonhttp://orcid.org/0000-0002-0730-3018, and Dmitri V. Talapin*Dmitri V. TalapinDepartment of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, United StatesCenter for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, United States*D. V. Talapin. E-mail: [email protected]More by Dmitri V. Talapinhttp://orcid.org/0000-0002-6414-8587Cite this: Chem. Mater. 2018, 30, 11, 3623–3627Publication Date (Web):May 21, 2018Publication History Received16 March 2018Revised2 May 2018Published online21 May 2018Published inissue 12 June 2018https://pubs.acs.org/doi/10.1021/acs.chemmater.8b01137https://doi.org/10.1021/acs.chemmater.8b01137rapid-communicationACS PublicationsCopyright © 2018 American Chemical SocietyRequest reuse permissionsArticle Views4664Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption spectroscopy,Indium arsenide,Nucleation,Precursors,Quantum dots Get e-Alerts
Simulation of Impact Energy on Coil Spring by Shot Peening (2003)

This subject focuses on the simulated shot peening analysis of the impact energy and simulated impact energy distribution on coil spring. The authors studied hit condition by changing peening angle, and checked relationship between impact energy and residual stress. There have been no report that describes an analysis on the simulated shot peening effect on helical material whereas reports on flat material exist. In this paper, shot size, peening angle, and spring wire overlapping are considered. The effectiveness of this analysis is verified in comparison with the previous test result where light was used to check the shadow of shot shower.
Synthesis, Structure, and Properties of Alternating and Random Poly(styrene-b-butadiene) Multiblock Copolymers (2013)

We report a synthetic method for the preparation of well-defined poly(styrene-b-butadiene) (PS-PB)n multiblock copolymers using a combination of living anionic polymerization and urethane based polycondensation along with an assessment of the associated microphase morphology and thermal and mechanical properties. The prepolymers, α,ω-dihydroxy polystyrene (HO-PS-OH) and α,ω-dihydroxy polybutadiene (HO-PB-OH), were prepared using a protected initiator, followed by deprotection and condensation with isophorone diisocyanate (IPDI) leading to the (PS-PB)n multiblock copolymers. Two types of block sequences were generated, one with random block sequences (PS-ran-PB)n and the second with alternating (PS-alt-PB)n block architectures. Size exclusion chromatography (SEC), 1H nuclear magnetic resonance (NMR), and Fourier transform infrared spectrometry (FTIR) confirmed that the synthetic procedures yielded the desired products. Differential scanning calorimetry (DSC) revealed microphase separation and small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) demonstrated that the multiblock materials, containing between 69% and 85% by volume glassy PS, are characterized by a disordered bicontinuous-like morphology. Tensile tests demonstrated yielding followed by necking and an overall ductility that translates into much greater toughness than that typically found in glassy continuous SBS triblock copolymers.
The Sulfur Dioxide Removal and Regeneration Properties of MgO-Based Sorbents Promoted with Ceria and Iron Oxide (2010)

Nano-size MgO-based sorbents that were promoted with ceria and iron oxide were prepared using the coprecipitation method. The sulfur removing capacity and the role of ceria and iron oxide promoters were investigated using a fixed-bed reactor and X-ray diffraction (XRD). The ceria played an important role in the catalytic oxidation of SO 2 to SO 3 which could be easily absorbed by the MgO. In order for sulfate absorption to occur, SO 2 must be oxidized to SO 3 before absorption to a pure MgO. The iron oxide exhibited a lowering of the regeneration temperature of the sulfated sorbent under a residue fluid catalytic cracking (RFCC) condition. These results can be explained by the presence of iron oxide particles that interact strongly with MgO support. The MgO-based sorbent that was promoted with ceria and iron oxide showed excellent characteristics in that it could satisfy a large amount of SO 2 absorption and fast regeneration.
Profiling Cell-Biomaterial Interactions Via Cell-Based Fluororeporter Imaging (2007)

Cell-based, high-throughput screening has revolutionized the development of small-molecule pharmaceuticals. A similar paradigm for the accelerated development of biomaterials for cell and tissue engineering involves the iterative use of combinatorial biomaterial synthesis, rapid cellular response screens, and computational modeling methods. However assays to probe cell responses to biomaterials are frequently subjective, lack dynamic responsiveness, and are limited to low-throughput experimentation. In this report, we highlight the use of high-resolution imaging of cell-based fluororeporters to establish and correlate quantifiable metrics of cell functional endpoints (e.g., cell growth, cell adhesion, cell attachment strength), as well as of intracellular cytoskeletalfeatures (e.g., descriptors of actin organization) on a set of model biomaterial substrates synthesized by combinatorial variations. Selected mammalian cell lines were genetically engineered with a series of green fluorescent protein (GFP)fusion genes to allow for live cell imaging on biomaterials. We demonstrate that high-content imaging yields a large number of quantifiable morphometric descriptors of ultrastructural cell features (e.g., cell cytoskeleton) in conjunction with densitometric descriptors of cell behaviors (e.g., cell apoptosis). We illustrate how such descriptors can be used to discern combinatorial variations in substrate composition, and how living GFP reporters are uniquely suited to generate such descriptors unlike fixed tissue preparations. This quantitative approach of live fluororeporter cell imaging could be valuable for metrology of cell-material interactions.
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors (2017)

Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies to target PTCL biology represents an urgent need. Here we report that PTCL are sensitive to transcription-targeting drugs, and, in particular, to THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7). The STAT-signalling pathway is highly vulnerable to THZ1 even in PTCL cells that carry the activating STAT3 mutation Y640F. In mutant cells, CDK7 inhibition decreases STAT3 chromatin binding and expression of highly transcribed target genes like MYC, PIM1, MCL1, CD30, IL2RA, CDC25A and IL4R. In surviving cells, THZ1 decreases the expression of STAT-regulated anti-apoptotic BH3 family members MCL1 and BCL-XL sensitizing PTCL cells to BH3 mimetic drugs. Accordingly, the combination of THZ1 and the BH3 mimetic obatoclax improves lymphoma growth control in a primary PTCL ex vivo culture and in two STAT3-mutant PTCL xenografts, delineating a potential targeted agent-based therapeutic option for these patients.
Social distancing estimation using an IoT-based system and Bluetooth signal detection (2021)

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