gebhart/patrepeval huggingface dataset:
A nomogram predicting disease-specific survival after nephrectomy for papillary renal cell carcinoma (2009)

5091 Background: Whereas multiple nomograms have been developed to assess outcomes of patients with clear cell renal cell carcinoma, a model to assess prognosis of papillary renal cell carcinoma (PRCC) has not yet been developed. After data collection and slide review of a large cohort of patients, the aim of this study was to develop and to internally validate a nomogram for prediction of disease-specific survival for PRCC. Methods: Out of 2,687 patients who underwent surgery for a renal tumor between 1989 and 2008 at two institutions, 258 (10%) were found to have PRCC. H&amp;E slides were reviewed by one uro-pathologist at each institution for papillary sub-type, tumor grade, microvascular invasion, sarcomatoid features, collecting system invasion and presence and extent of tumor necrosis. A nomogram was constructed as a graphical representation of significant variables of disease-specific survival in multivariate Cox proportional hazards regression analysis. The discrimination and calibration of the nomogram were assessed, both utilizing bootstrapping to obtain relatively unbiased estimates. Results: After a median follow-up of 35 months, 49 PRCC-related deaths (19%) had occurred. In univariate analysis, incidental detection, T, N, M stage, grade, microvascular invasion, collecting system invasion, papillary sub-type, sarcomatoid features, and necrosis were all associated with prognosis. Multivariate Cox proportional hazards analysis, however, identified incidental detection, T stage, M stage, microvascular invasion, and necrosis, but not papillary sub-type as independent prognostic factors of disease-specific survival. These variables formed the basis of the nomogram that predicted 5-year disease-specific survival probability. The nomogram predicted well, with a bootstrapped corrected concordance index of 0.93, and showed good calibration. Conclusions: A highly accurate tool utilizing basic clinical and pathological information for predicting disease-specific survival was developed specifically for PRCC. This tool should be helpful for identification of the subset of PRCC patients with aggressive clinical behavior, and may contribute to the ability to individualize postoperative surveillance and therapy. No significant financial relationships to disclose.
A Case of Ramsay Hunt-Like Syndrome Caused by Herpes Simplex Virus Type 2 (2005)

We report an immunocompetent patient with recurrent auricular and facial vesicles associated with painful paresthesias and facial paralysis, consistent with Ramsay Hunt syndrome, due to herpes simplex virus (HSV) type 2. Clinical and laboratory-proven acyclovir resistance developed during therapy. Immunologic assays revealed normal reactivity to HSV-2.
ChemInform Abstract: Highly Efficient Green Phosphorescent OLED Based on Pyridine‐Containing Starburst Electron‐Transporting Materials. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Speaker dependent expression predictor from text: Expressiveness and transplantation (2014)

Automatically generating expressive speech from plain text is an important research topic in speech synthesis. Given the same text, different speakers may interpret it and read it in very different ways. This implies that expression prediction from text is a speaker dependent task. Previous work presented an integrated method for expression prediction and speech synthesis which can be used to model the diverse expressions in human's speech and build speaker dependent expression predictors from text. This work extends the integrated method for expression prediction and speech synthesis into a framework for speaker and expression factorization. The expressions generated by the speaker dependent expression predictors can be represented in a shared expression space, and in this space the expressions can be transplanted between different speakers. The experimental results indicate that based on the proposed method, the expressiveness of the synthetic speech can be improved for different speakers. Furthermore this work also shows how important the speaker specific information is for the performance of the expression predictor from text.
Data for comparative proteomics analysis of the antitumor effect of CIGB-552 peptide in HT-29 colon adenocarcinoma cells (2015)

CIGB-552 is a second generation antitumor peptide that displays potent cytotoxicity in lung and colon cancer cells. The nuclear subproteome of HT-29 colon adenocarcinoma cells treated with CIGB-552 peptide was identified and analyzed [1]. This data article provides supporting evidence for the above analysis.
Superconducting-switch program. Final interim report, January 1987-April 1988 (1989)

This is the final report of work done to study the feasibility of a superconducting opening switch. This phase of the investigation considers the following: (1) The achievement of critical current densities of over 10{sup 7} power A/sq cm in NbN. (2) Determination of the power required to operate a superconducting switch. (3) Utilization of materials other than NbN in such a switch.
Rheological Study of Micro Particle Laden Polymeric Thermal Interface Materials: Part 2 — Modeling (2002)

Currently there are no models to predict the thickness or the bondline thickness (BLT) of particle laden polymeric thermal interface materials (TIM) for parameters such as particle volume fraction and pressure. TIMs are used to reduce the thermal resistance. Typically this is achieved by increasing the thermal conductivity of these TIMs by increasing the particle volume fraction, however increasing the particle volume fraction also increases the BLT. Therefore, increasing the particle volume fraction may lead to an increase in the thermal resistance after certain volume fraction. This paper introduces a model for the prediction of the BLT of these particle laden TIMs. Currently thermal conductivity is the only metric for differentiating one TIM formulation from another. The model developed in this paper introduces another metric: the yield stress of these TIMs. Thermal conductivity and the yield stress together constitute the complete set of material parameters needed to define the thermal performance of particle laden TIMs.
Search for Heavy Neutrinos andWRBosons with Right-Handed Couplings in a Left-Right Symmetric Model inppCollisions ats=7  TeV (2012)

Results are presented from a search for heavy, right-handed muon neutrinos, N(μ), and right-handed W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0 fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W(R) mass, dependent on the value of M(W(R)). The excluded region in the two-dimensional (M(W(R)), M(N(μ)) mass plane extends to M(W(R))=2.5 TeV.
Improvement of depth resolution on photoacoustic imaging using multiphoton absorption (2007)

Commercial imaging systems, such as computed tomography and magnetic resonance imaging, are frequently used powerful tools for observing structures deep within the human body. However, they cannot precisely visualized several-tens micrometer-sized structures for lack of spatial resolution. In this presentation, we propose photoacoustic imaging using multiphoton absorption technique to generate ultrasonic waves as a means of improving depth resolution. Since the multiphoton absorption occurs at only the focus point and the employed infrared pulses deeply penetrate living tissues, it enables us to extract characteristic features of structures embedded in the living tissue. When nanosecond pulses from a 1064-nm Nd:YAG laser were focused on Rhodamine B/chloroform solution (absorption peak: 540 nm), the peak intensity of the generated photoacoustic signal was proportional to the square of the input pulse energy. This result shows that the photoacoustic signals can be induced by the two-photon absorption of infrared nanosecond pulse laser and also can be detected by a commercial low-frequency MHz transducer. Furthermore, in order to evaluate the depth resolution of multiphoton-photoacoustic imaging, we investigated the dependence of photoacoustic signal on depth position using a 1-mm-thick phantom in a water bath. We found that the depth resolution of two-photon photoacoustic imaging (1064 nm) is greater than that of one-photon photoacoustic imaging (532 nm). We conclude that evolving multiphoton-photoacoustic imaging technology renders feasible the investigation of biomedical phenomena at the deep layer in living tissue.
Efficient Registration Method of Medical Images using GPU (2010)

Registration of medical images is an important task; however, automatic image-based registration is computationally
expensive. Given this task, the authors propose an efficient rigid registration method, which is based on
mutual information and uses a graphics processing unit (GPU). Mutual-information-based registration methods
require joint-histogram computation. Although a GPU can provide high performance computing, a joint histogram
has a large number of bins, and the computation of such a histogram is not suitable for a GPU (whose
shared memory is limited). Taking advantage of the fact that one image (the reference image) is not transformed
during the registration process, the proposed method computes a joint histogram by computing multiple onedimensional
histograms and combining them. The method can therefore be efficiently implemented on a GPU
even with limited shared memory. Experimental results for 256 × 256 × 256 image registration show that the
method is about 140 times faster than a standard implementation on a CPU and 2.6 times faster than previous
methods using GPUs.
Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide. (2017)

The results add to the increasing evidence that the liver is the main source of plasma and ocular factor B protein, and demonstrate that reduction of liver factor B mRNA by an ASO results in a significant reduction in plasma and ocular factor B protein levels. The results suggest that inhibition of liver factor B mRNA by factor B ASOs would reduce systemic alternative complement pathway activation and has potential to be used as a novel therapy for AMD.
Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum (2021)

A series of morpholine analogs functionalized with hydroxyethylamine (HEA) pharmacophore was synthesized and assayed for the initial screening against Plasmodium falciparum 3D7 in culture, which suggested that analog 6k is a hit molecule with an inhibitory concentration of 5.059 ± 0.2036 μM.
Testing the Equivalence between Spatial Averaging and Temporal Averaging in Highly Dilute Solutions (2017)

Diffusion relates the flux of particles to the local gradient of the particle density in a deterministic way. The question arises as to what happens when the particle density is so low that the local gradient becomes an ill-defined concept. The dilemma was resolved early last century by analyzing the average motion of particles subject to random forces whose magnitude is such that the particles are always in thermal equilibrium with their environment. The diffusion dynamics is now described in terms of the probability density of finding a particle at some position and time and the probabilistic flux density, which is proportional to the gradient of the probability density. In a time average sense, the system thus behaves exactly like the ensemble average. Here, we report on an experimental method and test this fundamental equivalence principle in statistical physics. In the experiment, we study the flux distribution of 20 nm radius polystyrene particles impinging on a circular sink of micrometer dimensions. The particle concentration in the water suspension is approximately 1 particle in a volume element of the dimension of the sink. We demonstrate that the measured flux density is exactly described by the solution of the diffusion equation of an infinite system, and the flux statistics obeys a Poissonian distribution as expected for a Markov process governing the random walk of noninteracting particles. We also rigorously show that a finite system behaves like an infinite system for very long times despite the fact that a finite system converges to a zero flux empty state.
One-Pot Synthesis of Dihalo(porphyrinato)osmium(IV) Complexes. Evidence for Monohalo(carbonyl)osmium(III) Intermediates (1996)

trans-Dichloro-, trans-dibromo-, and trans-diiodoosmium(IV) tetraarylporphyrins were obtained by extremely facile synthetic routes directly from the reactions of the corresponding (carbonyl)osmium(II) complexes with CCl(4), CBr(4), and CI(4), respectively. At short reaction times, appreciable amounts of intermediates-one for each reaction-were observed by spectroscopic investigations. These intermediates were shown to be (carbonyl)(halo)(porphyrinato)osmium(III) complexes by independent preparation of an authentic (carbonyl)(bromo)(porphyrinato)osmium(III) complex, which was identical to the reaction intermediate in the reaction of CBr(4) and very similar to those of the other reactions. This provided strong evidence for the reaction mechanism, two stepwise one-electron oxidations of the metal ion. The relatively strong binding of carbon monoxide to osmium(III) is proposed to be an important factor in avoiding dimerization of the reaction intermediates.
Achromatic Broadband Visible Imaging with a 10cm Flat Lens (2021)

We demonstrate 10 cm achromatic flat multilevel diffractive lens with a focal length and thickness of 200mm and 2.4 µm, respectively operating across the entire visible band, which is the largest flat lens ever reported till date.
Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants (2021)

Filgotinib, an oral Janus kinase-1 preferential inhibitor, is approved in Europe and Japan for adults with rheumatoid arthritis. Patients with rheumatoid arthritis are at higher risk of cardiovascular morbidity/mortality; thus, it is important to understand potential drug-drug interactions of filgotinib with lipid-lowering agents. This open-label, randomized, 2-way crossover study evaluated the pharmacokinetics of atorvastatin, pravastatin, and rosuvastatin with and without filgotinib coadministration. Healthy participants (N = 27) received single doses of atorvastatin (40 mg) and of a pravastatin (40 mg)/rosuvastatin (10 mg) cocktail-alone or with filgotinib (200 mg once daily for 11 days)-on 2 different occasions with washout in between. Serial pharmacokinetic blood samples were collected, and safety was assessed. Pharmacokinetic parameters were evaluated using 90% confidence intervals (CI) of the geometric least-squares mean (GLSM) ratio of the test treatment (statin coadministration with filgotinib) vs statin alone, with prespecified lack-of-interaction bounds of 0.70 to 1.43. Coadministration of filgotinib did not affect atorvastatin area under the plasma concentration-time curve extrapolated to infinity (AUC<sub>inf</sub> ; [GLSM ratios (90% CI): 0.91 (0.84-0.99)]), but maximum concentration [C<sub>max</sub> ] was slightly lower [0.82 (0.69-0.99)]. The exposure of 2-hydroxy-atorvastatin was unaffected (GLSM ratios [90% CI], 0.98 [0.81-1.19] for C<sub>max</sub> ; 1.11 [1.02-1.22] for AUC<sub>inf</sub> ). Pravastatin AUC<sub>inf</sub> was also unaffected (GLSM ratios, 1.22 [1.05-1.41], but C<sub>max</sub> was slightly higher 1.25 [1.01-1.54]). Rosuvastatin exposure was moderately higher with filgotinib coadministration-GLSM ratios (90% CI), 1.68 (1.43-1.97) for C<sub>max</sub> ; 1.42 (1.30-1.57) for AUC<sub>inf</sub> -but this was not considered clinically relevant. These results indicate that filgotinib has no clinically meaningful effect on exposure of atorvastatin, pravastatin, or rosuvastatin.
A caustic corrected UTD solution for the fields radiated by a source on a flat plate with a curved edge (1997)

Corrections to the uniform geometrical theory of diffraction (UTD) that account for the caustics caused by the coalescence of the diffraction points on a curved edge are derived. This creates a new curvature dependent diffraction coefficient that has not been previously accounted for in the UTD. The far-zone radiation by a short monopole mounted on an elliptic disk is analyzed using this caustic corrected UTD solution. Theoretical results are verified in the principal plane by comparison with a method of moments solution. The resulting solution for the radiated field is accurate and provides useful insight into the scattering phenomena. This insight is necessary in order to obtain more general solutions.
Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp. II. Structure Elucidation. (2000)

A novel 16-membered lactone antibiotic named tubelactomicin A was isolated from the culture broth of Nocaradia sp. MK703-102F1. The structure of tubelactomicin A was assigned by spectroscopic analysis and the absolute configuration was determined by X-ray crystallographic analysis.
On the design of signal sets with constrained magnitude spectrum and phase structure (2002)

Abstract In this paper, a new method is introduced for designing signals that have low cross‐correlation among them with constant passband magnitude spectrum and quadratic phase. It is shown that in order to get low values of the cross‐correlation magnitude between any two signals in the set, the coefficients of the phase functions should be equally spaced along one axis of an ellipse determined by the bandwidth and time duration of signals. Furthermore, as an estimate of the maximum cross‐correlation magnitude, a new tighter upper bound is also given in the paper. Copyright © 2002 John Wiley &amp; Sons, Ltd.
The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones (2023)

Inositol phosphates (InsPs) are ubiquitous in all eukaryotes. However, since there are 63 possible different phosphate ester isomers, the analysis of InsPs is challenging. In particular, InsP<sub>1</sub>, InsP<sub>2,</sub> and InsP<sub>3</sub> already amass 41 different isomers, of which some occur as enantiomers. Profiling of these "lower" inositol phosphates in mammalian tissues requires powerful analytical methods and reference compounds. Here, we report an analysis of InsP<sub>2</sub> and InsP<sub>3</sub> with capillary electrophoresis coupled to electrospray ionization mass spectrometry (CE-ESI-MS). Using this method, the bacterial effector RipBL1 was analyzed and found to degrade InsP<sub>6</sub> to Ins(1,2,3)P<sub>3</sub>, an understudied InsP<sub>3</sub> isomer. This new reference molecule then aided us in the assignment of the isomeric identity of an InsP<sub>3</sub> while profiling human samples: in urine and kidney stones, we describe for the first time the presence of defined and abundant InsP<sub>3</sub> isomers, namely Ins(1,2,3)P<sub>3</sub>, Ins(1,2,6)P<sub>3</sub> and/or Ins(2,3,4)P<sub>3</sub>.
Impact of Compressor Protection System on Rundown Characteristics (2005)

Knowledge of compressor system behaviour during trip is essential to obtain reliable operation. Experience at Troll Kollsnes gas treatment plant has shown that the compressor can suffer from surge and rotating stall in situations with voltage drops in the electricity grid. The electric motor driven compressor and the protection valves and piping has been modelled and dynamic simulations has been done to reveal the transient response. An elaborate plant model has been created with the dynamic simulation tool OTISS by AspenTech and tuned to represent the plant. The paper focuses on the impact of different compressor discharge volumes, dimensions of the recycle piping as well as the sizing, characteristics and trip signal delay of the recycle protection valve(s). Sensitivity analyses for the actual plant reveal the response and protection during compressor driver trip.
Assessment of Therapeutic Tumor Response Using 99mTc-Ethylenedicysteine-Glucosamine (2004)

Purpose: The aim of this study was to evaluate 99mTc-ethylenedicysteine-glucosamine (EC-DG) for the assessment of tumor growth. Method: To evaluate whether 99mTc-EC-DG is involved in cell nuclei activity, in vitro thymidine incorporation, and cell-cycle assays of EC-DG were conducted using lung and breast cancer cells. Biodistribution of 99mTc-EC-DG in lung tumor–bearing mice (0.5–4 hours, 1 mCi/mouse, i.v.) was used to estimate the radiation-absorbed dose. Autoradiograms of 99mTc-EC-DG and 18F-FDG were compared in nude mice bearing uterine sarcoma. Rabbits inoculated with VX-2 cells were imaged with 99mTc-EC-DG and 99mTc-EC. For therapeutic assessment studies, scintigraphic imaging studies with 99mTc-EC-DG in mammary tumor–bearing rats were conducted at various days after treatment with paclitaxel and cisplatin. The imaging findings were correlated immunohistochemical assays (mRNA expression, apoptosis, and cell-cycle changes in tumor), and flow cytometry analysis was performed. Results: In vitro cellular uptake assays indicated that cell nuclei activity could be assessed by 99mTc-ECDG. Scintigraphy and autoradiograms in animal models demonstrated that the tumor could be clearly visualized by 99mTc-EC-DG. The efficacy of paclitaxel and cisplatin treatment in rodent models could be assessed using tumor/muscle ratios. Immunohistochemical staining indicated a reduced expression of bFGF and an increased apoptosis and cell-cycle changes after paclitaxel and cisplatin treatment. Conclusion: 99mTc-EC-DG is involved in cell nuclei activity and could assess the therapeutic tumor response.
Compensation for unconstrained catheter shaft motion in cardiac catheters (2016)

Cardiac catheterization with ultrasound (US) imaging catheters provides real time US imaging from within the heart, but manually navigating a four degree of freedom (DOF) imaging catheter is difficult and requires extensive training. Existing work has demonstrated robotic catheter steering in constrained bench top environments. Closed-loop control in an unconstrained setting, such as patient vasculature, remains a significant challenge due to friction, backlash, and physiological disturbances. In this paper we present a new method for closed-loop control of the catheter tip that can accurately and robustly steer 4-DOF cardiac catheters and other flexible manipulators despite these effects. The performance of the system is demonstrated in a vasculature phantom and an <i>in vivo</i> porcine animal model. During bench top studies the robotic system converged to the desired US imager pose with sub-millimeter and sub-degree-level accuracy. During animal trials the system achieved 2.0 mm and 0.65° accuracy. Accurate and robust robotic navigation of flexible manipulators will enable enhanced visualization and treatment during procedures.