gebhart/patrepeval huggingface dataset:
Distributed Opportunistic Scheduling for Wireless Ad-Hoc Networks with Block-Fading Model (2013)

In this paper, we study a distributed opportunistic scheduling problem to exploit the channel fluctuations in wireless ad-hoc networks. In this problem, channel probing is followed by a transmission scheduling procedure that is executed independently within each link in the network. We study this problem for the popular block-fading channel model, where channel dependencies are inevitable between different time instances during the channel probing phase. Different from existing works, we explicitly consider this type of channel dependencies and its impact on the transmission scheduling and hence the system performance. We use optimal stopping theory to formulate this problem, but at carefully chosen time instances at which effective decisions are made. The problem can then be solved by a new stopping rule problem where the observations are independent between different time instances. Since the stopping rule problem has an implicit horizon determined by the network size, we first characterize the system performance using backward induction. We develop one recursive approach to solve the problem and show that the computational complexity is linear with respect to the network size. Due to its computational complexity, we present an approximation for performance analysis and develop a metric to check how good the approximation is. We characterize the achievable system performance if we ignore the finite horizon constraint and apply the stopping rules based on the infinite horizon analysis nevertheless. We present an improved protocol to reduce the probing costs which requires no additional cost. We characterize the performance improvement and the energy savings in terms of the probing signals. We show numerical results based on our mathematical analysis with various settings of parameters.
Reduction of 1/f noise in multiplexed linear In/sub 0.53/Ga/sub 0.47/As detector arrays via epitaxial doping (1993)

A significant (2-5*) reduction in 1/f noise was observed in In/sub 0.53/Ga/sub 0.47/As photodetector arrays read out by a PMOS multiplexer, when the epitaxial InP cap layer doping was changed from undoped to sulfur-doped n type of about 3*10/sup 16/ cm/sup -3/. A further decrease was observed when the InP buffer layer was also changed from undoped to sulfur-doped n type of about 5*10/sup 17/ cm/sup -3/. Data was presented for the variation of 1/f noise, within a temperature range of 18 degrees C to -40 degrees C. Surface states at the InP cap/SiN interface appears to be the primary source of 1/f noise, with the bulk states at the n/sup -/In/sub 0.53/Ga/sub 0.47/As buffer hetero-interface as a secondary source. Increased n-type doping in the high-bandgap InP cap and buffer layers may reduce electron trapping, and thus 1/f noise. The measured noise spectrum of InGaAs photodetectors varies as f/sup y/ with y being approximately -0.45 for device structures with doped and undoped InP can layers. For a doped InP buffer layer, this value of y is -0.3.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors (electron spin-resonance spin trappingytetrahydrobiopterinyf lavinsyL-arginineynitric oxide synthase inhibitors) (1998)

The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide. In the absence of calciumycalmodulin, eNOS produces low amounts of superoxide. Upon activating eNOS electron transfer reac- tions by calciumycalmodulin binding, superoxide formation is increased. Heme-iron ligands, cyanide, imidazole, and the phenyl(diazene)-derived radical inhibit superoxide genera- tion. No inhibition is observed after addition of L-arginine, N G -hydroxy-L-arginine, L-thiocitrulline, and L-N G -mono- methyl arginine to activated eNOS. These results demonstrate that superoxide is generated from the oxygenase domain by dissociation of the ferrous-dioxygen complex and that occu- pation of the L-arginine binding site does not inhibit this process. However, the concomitant addition of L-arginine and tetrahydrobiopterin (BH4) abolishes superoxide generation by eNOS. Under these conditions, L-citrulline production is close to maximal. Our data indicate that BH4 fully couples L-arginine oxidation to NADPH consumption and prevents dissociation of the ferrous-dioxygen complex. Under these conditions, eNOS does not generate superoxide. The presence of f lavins, at concentrations commonly employed in NOS assay systems, enhances superoxide generation from the reductase domain. Our data indicate that modulation of BH4 concentration may regulate the ratio of superoxide to nitric oxide generated by eNOS.
High Power and High Reliability Flex-On-Board Assembly Using Solder Anisotropic Conductive Films Combined With Ultrasonic Bonding Technique (2011)

To realize an ultrathin and fine-pitch flex-on-board module assembly with high power handling capability and excellent reliability, ultrasonic (US) bonding technology with solder anisotropic conductive films (ACFs) was successfully demonstrated. This technology provides fluxless soldering within a polymer adhesive matrix on metal electrodes using solder ACFs combined with the room temperature US bonding technique. According to experimental results, the temperature of the solder ACF joints showed rapid heating rates up to 400°C/s and reached at above 250°C under US vibration. The ACF temperature could be precisely controlled from 75°C to 260°C by adjusting US vibration amplitudes from 4 to 13 μm. At above the melting temperatures of solder particles, US-bonded solder ACF joints showed stable solder metallurgical joints alloyed with metal electrodes and more than 90% curing of ACFs within 5 s bonding time. At the same time, US-bonded solder ACF joints showed about 30% reduced electrical joint resistances, more than 90% improved current handling capability and significantly enhanced reliability in an unbiased autoclave test (121°C, 2 atm, 100%RH) compared with conventional Ni ACF joints. The significance of this paper is that the fluxless solder metallurgical joining and adhesive bonding can occur at the same time, and realizes not only enhanced ACF joint properties but also reduced ACF bonding time within 5 s at room temperature.
Delamination of Tantalum Porous Coating From a TKA Due to Regional Dissemination of Debris (2013)

Metallic debris from metal-on-metal bearings is a recognized mode of failure that may lead to implant loosening and periprosthetic soft tissue reactions. The sequelae of metallosis have been most commonly reported with respect to total hip arthroplasty. The authors report a rare case of metallosis following a hybrid metal-on-polyethylene total knee arthroplasty that used a porous tantalum tibial knee component. A total knee arthroplasty patient who presented with knee pain but normal radiographs was found to have delamination of her tibial component that resulted in marked periprosthetic soft tissue metallosis.
Therapeutic Potential of Targeting PAK Signaling (2015)

The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human trails (PF-3758309). The best studied functional roles of PAK proteins are control of cell adhesion and migration. PAK proteins are known downstream effectors of Ras signaling with PAK expression elevated in cancer (pancreatic, colon, breast, lung and other solid tumors). In addition altered PAK expression is a confirmed driver of this disease, especially in tumors harboring oncogenic Ras. However, there are very few examples of gain-of-function PAK mutations, as a majority of the cancer types have elevated PAK expression due to gene amplification or transcriptional modifications. There is a substantial number of known substrates affected by this aberrant PAK activity. One particular substrate, &#946;-catenin, has garnered interest given its importance in both normal and cancer cell development. These data place PAK proteins between two major signaling pathways in cancer (Ras and &#946; -catenin), making therapeutic targeting of PAKs an intriguing approach for the treatment of a broad array of oncological malignancies.
ChemInform Abstract: Furomegistines I and II, Two Furanopyridine Alkaloids from the Bark of Sarcomelicope megistophylla. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Selective Iridium‐Catalyzed Asymmetric Hydrogenation of Trifluoromethyl Olefins: A New Route to Trifluoromethyl‐Bearing Stereocenters. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Switching of Polymer-Stabilized Vertical Alignment Liquid Crystal Pi Cell-Curing Voltage and Driving Scheme Effects (2009)

We investigate the electrooptical properties of polymer-stabilized vertically aligned (PSVA) pi cells. Curing a cell with a curing voltage causes the polymerized cell to have a low threshold voltage and a fast field-on response time, because the curing voltage gives the polymerized cell in-cell polymer structures, inhibiting the flow of the liquid crystal (LC) domains and also providing the LCs a sustained pretilt angle. Additionally, under high-voltage operation, the field-on and field-off response times of the PSVA pi cell operated under the step voltage driving scheme are found to be less than those of the cell operated under the conventional bias voltage driving scheme, because the electric torques exerted on the LCs in the step voltage driving scheme are higher than those exerted on the LCs in the bias voltage driving scheme.
The impact of obesity on the mid-term outcome of cementless total knee replacement (2009)

We evaluated 535 consecutive primary cementless total knee replacements (TKR). The mean follow-up was 9.2 years (0.3 to 12.9) and information on implant survival was available for all patients. Patients were divided into two groups: 153 obese patients (BMI > or = 30) and 382 non-obese (BMI < 30). A case-matched study was performed on the clinical and radiological outcome, comparing 50 knees in each group. We found significantly lower mean improvements in the clinical score (p = 0.044) and lower post-operative total clinical scores in the obese group (p = 0.041). There was no difference in the rate of radiological osteolysis or lucent lines, and no difference in alignment. Log rank test for survival showed no significant differences between the groups (p = 0.167), with a ten-year survival rate of 96.4% (95% confidence interval (CI) 92 to 99) in the obese and 98% (95% CI 96 to 99) in the non-obese. The mid-term survival of TKR in the obese and the non-obese are comparable, but obesity appears to have a negative effect on the clinical outcome. However, good results and high patient satisfaction are still to be expected, and it would seem unreasonable to deny patients a TKR simply on the basis of a BMI indicating obesity.
The Molecular Structure and Crystal Organization Of Rac -terfenadine/β-cyclodextrin/tartaric Acid Multicomponent Inclusion Complex (2002)

The crystalline ternary inclusion complex terfenadine/ g -cyclodextrin/tartaric acid (TFN/ g CD/TA, 2:4:1) has been prepared from a aqueous solution (terfenadine, TFN, rac - f -[4-(1,1-dimethylethyl)phenyl]-4-(hydroxy-diphenylmethyl)-1-piperidine-butanol). The solubility of the multicomponent system in water is remarkably different from that of the single components. The crystal structure shows that the TFN guest adopts an extended conformation and that the diphenyl end of the molecule is docked in the cavity formed by the association of two independent g CD molecules through hydrogen bonds connecting their wide rims. The structure of the dimer is deformed with respect to uncomplexed g CDs, due to the shape of the guest. The two aromatic rings interact differently with the macrocycles forming the dimer, one being included perpendicular in the central cavity of one g CD, the other laying parallel to the interface between the two rims. The t-Bu- end of the guest is included in the cavity of a g CD belonging to a different dimer, entering from the side of the narrow rim. The central part of the guest is surrounded by water molecules and tartaric acid, which creates a hydrophilic microenvironment in the interstices among dimers. The enhanced solubility of the multicomponent system could be related to the hydrogen bonds between the tartaric acid and the oxygens belonging to the wide rims. The overall structural arrangement of the g CD units is driven by the shape of the TFN guest which needs a hydrophobic environment at both ends. The lipophilic interactions between TFN and g CD cavities are responsible for the relevant perturbation in the regularity of the packing of the hosts. Keywords: Multicomponent ComplexesHost-guest ChemistryCyclodextrinTerfenadineTartaric AcidX-ray Crystallography
On low-slip tire friction behavior and modeling for different road conditions (2005)

There have been several experimental studies in the last fifteen years, which show that the gradient of tire static curve in the low-slip region depends on road condition. This result has been in a contrast to the traditional tire theory which relates the low-slip gradient of tire static curve to tire parameters only. This paper presents a detailed experimental analysis of low-slip static tire behavior for different road conditions such as dry concrete, dry and wet ice, and dry and wet snow. The emphasis of the paper is on an analysis of various tire/road effects which can influence the low-slip static behavior, and related tire modeling aspects.
Compact UWB Bandpass Filter as Cascaded Center-Tapped CRLH Transmission-Line ZORs for Improved Stopband (2013)

The design of a new compact UWB bandpass filter is proposed which has cascaded center-tapped microstrip composite right/left-handed transmission-line zeroth-order resonators (CRLH-TL ZORs). In an attempt to reduce the size. instead of the convention half-wavelength resonators or periodic and multiple CRLH-TL cells, only one cell ZOR geometry is adopted as each resonator in the filter. Additionally, two center-tapped ZORs are coupled to increase the slope of the skirt. Besides, stepped impedance matching parts are placed in the paths to the input and output ports to enhance passband and stopband performances. The proposed filter is shown to have the overall size of 0.69 λ g × 0.70 λ g the insertion loss much less than 1 dB, and an acceptable return loss performance in the predicted and measured results.
Supplementary Analysis from Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas (2023)

Supplementary Analysis from Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas
P‐6: Student Poster: 2731ppi OLED Display with Low Power Consumption and Wide Viewing Angle Using OS/Si VLSI Process Technology (2022)

A 2731‐ppi OLED display was fabricated. Its source and scan drivers comprise Si transistors, and its pixel circuit comprises oxide semiconductor field‐effect transistors monolithically formed directly on the Si transistors.
Transverse Relaxation of Scalar‐Coupled Protons (2010)

Abstract In a preliminary communication (B. Baishya, T. F. Segawa, G. Bodenhausen, J. Am. Chem. Soc. 2009 , 131 , 17538–17539), we recently demonstrated that it is possible to obtain clean echo decays of protons in biomolecules despite the presence of homonuclear scalar couplings. These unmodulated decays allow one to determine apparent transverse relaxation rates R 2 app of individual protons. Herein, we report the observation of R 2 app for three methyl protons, four amide H N protons, and all 11 backbone H α protons in cyclosporin A. If the proton resonances overlap, their R 2 app rates can be measured by transferring their magnetization to neighboring 13 C nuclei, which are less prone to overlap. The R 2 app rates of protons attached to 13 C are faster than those attached to 12 C because of 13 C– 1 H dipolar interactions. The differences of these rates allow the determination of local correlation functions. Backbone H N and H α protons that have fast decay rates R 2 app also feature fast longitudinal relaxation rates R 1 and intense NOESY cross peaks that are typical of crowded environments. Variations of R 2 app rates of backbone H α protons in similar amino acids reflect differences in local environments.
Biochemical Characterization of the First Essential Two-Component Signal Transduction System from <i>Staphylococcus aureus</i> and <i>Streptococcus pneumoniae</i> (2003)

The YYCFG two-component signal transduction system (TCSTS) has been shown to be essential to the viability of several gram-positive bacteria. However, the function of the gene pair remains unknown. Interestingly, while both components are essential to Staphylococcus aureus and Bacillus subtilis, only the response regulator (YYCF) is essential to Streptococcus pneumoniae. To study this essential TCSTS further, the S. pneumoniae and S. aureus truncated YycG histidine kinase and full-length YycF response regulator proteins were characterized at a biochemical level. The recombinant proteins from both organisms were expressed in Escherichia coli and purified. The YycG autophosphorylation activities were activated by ammonium. The apparent K(m )(ATP) of S. aureus YycG autophosphorylation was 130 microM and S. pneumoniae was 3.0 microM. Each had similar K(cat )values of 0.036 and 0.024 min(-1), respectively. Cognate phosphotransfer was also investigated indicating different levels of the phosphorylated YycG intermediates during the reaction. The S. pneumoniae YycG phosphorylated intermediate was not detectable in the presence of its cognate YycF, while phosphorylated S. aureus YycG and YycF were detected concurrently. In addition, noncognate phosphotransfer was demonstrated between the two species. These studies thoroughly compare the essential YycFG TCSTS from the two species at the biochemical level and also establish methods for assaying the activities of these antibacterial targets.
Analysis of solid phase crystallization in amorphized polycrystalline Si films on quartz substrates (1989)

The solid phase crystallization of amorphized Si films on quartz substances is studied by means of the transmission electron microscope observation of grain growth. The amorphous Si films are prepared by Si ion implantation into polycrystalline Si films deposited by low-pressure chemical vapor deposition. It has been found that the twin formation in grains at the early stage of the crystallization accelerates the growth rate preferentially in a 〈112〉 direction. During the twin growth about a given 〈112〉 direction, other twins also grow from the twin boundary dendritically in some other 〈112〉 directions, leading to the formation of a large grain of dendritic structure.
O Novo Regulamento Geral Sobre a Protecção de Dados e as Suas Implicações Quanto a Pedidos de Informação Dirigidos aos Profissionais de Saúde (2020)

N/a.
Data from Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival (2023)

&lt;div&gt;Abstract&lt;p&gt;Tumor-infiltrating CD8&lt;sup&gt;+&lt;/sup&gt; T cells are associated with improved survival of patients with Merkel cell carcinoma (MCC), an aggressive skin cancer causally linked to Merkel cell polyomavirus (MCPyV). However, CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration is robust in only 4% to 18% of MCC tumors. We characterized the T-cell receptor (TCR) repertoire restricted to one prominent epitope of MCPyV (KLLEIAPNC, “KLL”) and assessed whether TCR diversity, tumor infiltration, or T-cell avidity correlated with clinical outcome. HLA-A*02:01/KLL tetramer&lt;sup&gt;+&lt;/sup&gt; CD8&lt;sup&gt;+&lt;/sup&gt; T cells from MCC patient peripheral blood mononuclear cells (PBMC) and tumor-infiltrating lymphocytes (TIL) were isolated via flow cytometry. TCRβ (&lt;i&gt;TRB&lt;/i&gt;) sequencing was performed on tetramer&lt;sup&gt;+&lt;/sup&gt; cells from PBMCs or TILs (&lt;i&gt;n&lt;/i&gt; = 14) and matched tumors (&lt;i&gt;n&lt;/i&gt; = 12). Functional avidity of T-cell clones was determined by IFNγ production. We identified KLL tetramer&lt;sup&gt;+&lt;/sup&gt; T cells in 14% of PBMC and 21% of TIL from MCC patients. TRB repertoires were strikingly diverse (397 unique TRBs were identified from 12 patients) and mostly private (only one TCRb clonotype shared between two patients). An increased fraction of KLL-specific TIL (&gt;1.9%) was associated with significantly increased MCC-specific survival &lt;i&gt;P&lt;/i&gt; = 0.0009). T-cell cloning from four patients identified 42 distinct KLL-specific TCRa/b pairs. T-cell clones from patients with improved MCC-specific outcomes were more avid (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) and recognized an HLA-appropriate MCC cell line. T cells specific for a single MCPyV epitope display marked TCR diversity within and between patients. Intratumoral infiltration by MCPyV-specific T cells was associated with significantly improved MCC-specific survival, suggesting that augmenting the number or avidity of virus-specific T cells may have therapeutic benefit. &lt;i&gt;Cancer Immunol Res; 5(2); 137–47. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Classiﬁcation of Cervical Spine Trauma (2002)

Classiﬁcation of cervical spine injuries requires a clear understanding of the anatomy of the cervical spine and the mechanism of injury. Classiﬁcations are useful to clinicians when they provide treatment guidelines and have prognostic values. A better understanding of cervical trauma classiﬁcations and mechanisms of injury guides proper care of cervical spine injuries and reduces mortality and associated neurological injuries (1-5).
ESD robustness and scaling implications of aluminum and copper interconnects in advanced semiconductor technology (1997)

ESD testing results of aluminum and copper interconnect wires and vias for advanced semiconductor technologies demonstrate that interconnects will be a limiting failure mechanism in the future for ESD robustness of semiconductor chips. Comparison of copper and aluminum interconnect and via ESD robustness and failure mechanisms will be shown. Results demonstrate an improvement in the ESD robustness of a Cu-based interconnect system, compared to AI-based interconnects, with an improvement in the critical current, in the human body and machine model time regimes.
Long-chain α–ω diols from renewable fatty acids via tandem olefin metathesis–ester hydrogenation (2017)

Long chain α–ω diols were readily accessed from renewable fatty acid methyl esters following an orthogonal tandem self-metathesis–ester hydrogenation protocol.