gebhart/patrepeval huggingface dataset:
Structural Basis of Protein Kinase C Activation by Tumor Promoters (1998)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Basis of Protein Kinase C Activation by Tumor PromotersYoshito Kishi and Robert R. RandoView Author Information Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115 Cite this: Acc. Chem. Res. 1998, 31, 4, 163–172Publication Date (Web):March 18, 1998Publication History Received29 August 1997Published online18 March 1998Published inissue 1 April 1998https://doi.org/10.1021/ar9600751Copyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views531Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (202 KB) Get e-AlertscloseSUBJECTS:Hydrophilicity,Molecular structure,Peptides and proteins,Pharmacophores,Tumors Get e-Alerts
Measurement of the W±Z boson pair-production cross section in pp collisions at s=13 TeV with the ATLAS detector (2016)

The production of W Z events in proton-proton collisions at a centre-of-mass energy of 13 TeV is measured with the ATLAS detector at the LHC. The collected data correspond to an integrated luminosity of 3.2 fb -1 . The W Z candidates are reconstructed using leptonic decays of the gauge bosons into electrons or muons. The measured inclusive cross section in the detector fiducial region for leptonic decay modes is fid.
Comparative Analysis of Gene Expression in Normal and Degenerative Human Tendon Cells (2014)

These data might have future applications, including the identification of markers for early diagnosis, targets for drug design, and indicators for treatment responsiveness and prognosis.
Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner (2019)

Mitochondria affect cellular functions alone or in cooperation with other cellular organelles. Recent research has demonstrated the close relationship of mitochondria with the endoplasmic reticulum (ER), both at the physical and the functional level. In an effort to define the combined effect of mitochondrial dysfunction (MD) and ER stress in the proinflammatory activities of macrophages, the human macrophage-like monocytic leukemia cell line THP-1 was treated with mitochondrial electron transport chain (ETC) blockers, and changes in the cellular responses upon stimulation by interferon (IFN)-γ were analyzed. Inducing mitochondrial dysfunction (MD) with ETC blockers resulted in suppression of IFN-induced activation of JAK1 and STAT1/3, as well as the expression of STAT1-regulated genes. In addition, experiments utilizing pharmacological modulators of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and liver kinase B1 (LKB1)-deficient HeLa cells demonstrated that these suppressive effects are mediated by the LKB1-AMPK pathway. Treatment with pharmacological inhibitors of ER stress sensors failed to affect these processes, thus indicating that involvement of ER stress is not required. These results indicate that MD, induced by blocking the ETC, affects IFN-induced activation of JAK-STAT and associated inflammatory changes in THP-1 cells through the LKB1-AMPK pathway independently of ER stress.
Printable thermo-optic polymer switches utilizing imprinting and ink-jet printing (2013)

We demonstrate a printable Thermo-Optic (TO) switch utilizing imprinting and ink-jet printing techniques. The material system, optical and thermal designs are discussed. Imprinting technique is used to transfer a 2 × 2 switch pattern from a flexible mold into a UV15LV polymer bottom cladding. Ink-jet printing is further used to deposit a SU-8 polymer core layer on top. Operation of the switch is experimentally demonstrated up to a frequency of 1 kHz, with switching time less than 0.5 ms. The printing technique demonstrates great potential for high throughput, roll-to-roll fabrication of low cost photonic devices.
Advancements in shear strengthening of prestressed concrete I-girders using fiber reinforced polymers (2021)

&lt;p&gt;A number of attempts were made by different researchers in the last couple of decades to strengthen prestressed concrete (PC) I-girders in shear using externally bonded FRP (fibre reinforced polymer) reinforcement. The unanimous observation reported in the literature is the early debonding of FRP shear reinforcement around the internal angles of the I-section. Because of this undesirable phenomenon, the strength of the FRP is utilized inefficiently. This paper gives an overview of the techniques utilized in the past and their relative performance in order to develop a rational solution to the debonding problem, particularly for I-sections. The anchoring techniques used in the past includes different types of FRP anchors as well as mechanical anchors to protect FRP shear reinforcement from debonding on the I-section. It can be concluded that the definite solution to the debonding problem on I-sections has not been obtained yet. This is because of the complex failure modes of FRP shear reinforcement and PC I-girders.&lt;/p&gt;
Structure of Fluorinated Side-Chain Smectic Copolymers:  Role of the Copolymerization Statistics (2002)

International audience
Human cone photoreceptor dependence on RPE65 isomerase (2007)

The visual (retinoid) cycle, the enzymatic pathway that regenerates chromophore after light absorption, is located primarily in the retinal pigment epithelium (RPE) and is essential for rod photoreceptor survival. Whether this pathway also is essential for cone photoreceptor survival is unknown, and there are no data from man or monkey to address this question. The visual cycle is naturally disrupted in humans with Leber congenital amaurosis (LCA), which is caused by mutations in RPE65, the gene that encodes the retinoid isomerase. We investigated such patients over a wide age range (3-52 years) for effects on the cone-rich human fovea. In vivo microscopy of the fovea showed that, even at the youngest ages, patients with RPE65-LCA exhibited cone photoreceptor loss. This loss was incomplete, however, and residual cone photoreceptor structure and function persisted for decades. Basic questions about localization of RPE65 and isomerase activity in the primate eye were addressed by examining normal macaque. RPE65 was definitively localized by immunocytochemistry to the central RPE and, by immunoblotting, appeared to concentrate in the central retina. The central retinal RPE layer also showed a 4-fold higher retinoid isomerase activity than more peripheral RPE. Early cone photoreceptor losses in RPE65-LCA suggest that robust RPE65-based visual chromophore production is important for cones; the residual retained cone structure and function support the speculation that alternative pathways are critical for cone photoreceptor survival.
Evaluation and Management of the Atrial Fibrillation Patient (2013)

Atrial fibrillation (AF) is the most common cardiac dysrhythmia, and its prevalence is growing. The care of patients with AF is complex and involves multiple specialties and venues of care. Guideline recommendations are available for AF therapy; however, their implementation can be challenging. The Society of Cardiovascular Patient Care has developed an accreditation program, formulated by an expert committee on AF. Accreditation is based on specific criteria in 7 domains: (1) community outreach, (2) prehospital care, (3) early stabilization, (4) acute care, (5) transitions of care, (6) clinical quality measures, and (7) governance. This document presents the rationale, discussion, and supporting evidence for these criteria, in an effort to maximize effective and efficient AF care.
New combined system of biological process and intermittent ozonation for advanced wastewater treatment (1998)

A new system combining both biological treatment and intermittent ozonation has been developed to reduce excess sludge production with a small amount of ozone. In this system, activated sludge in the aeration tank was circulated via intermittent ozonation. Experimental results have shown that 50% of the sludge generation was cut down with only 30% of the ozone dose required for continuous ozonation. Furthermore, the process had a remarkable effect on maintaining the sludge settling characteristics. The sludge ozonation was almost of little influence on the effluent quality though the slight degradation of effluent quality was observed in few cases. These facts suggested the effectiveness of the newly proposed system for saving costs and stabilizing treatment performance of biological waste water treatment processes.
A Decentralized Damage Detection System for Wireless Sensor and Actuator Networks (2015)

The unprecedented capabilities of monitoring and responding to stimuli in the physical world of wireless sensor and actuator networks (WSAN) enable these networks to provide the underpinning for several Smart City applications, such as structural health monitoring (SHM). In such applications, civil structures, endowed with wireless smart devices, are able to self-monitor and autonomously respond to situations using computational intelligence. This work presents a decentralized algorithm for detecting damage in structures by using a WSAN. As key characteristics, beyond presenting a fully decentralized (in-network) and collaborative approach for detecting damage in structures, our algorithm makes use of cooperative information fusion for calculating a damage coefficient. We conducted experiments for evaluating the algorithm in terms of its accuracy and efficient use of the constrained WSAN resources. We found that our collaborative and information fusion-based approach ensures the accuracy of our algorithm and that it can answer promptly to stimuli (1.091 s), triggering actuators. Moreover, for 100 nodes or less in the WSAN, the communication overhead of our algorithm is tolerable and the WSAN running our algorithm, operating system and protocols can last as long as 468 days.
Angiotensin I-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction, but Not With Retinopathy or Nephropathy, in NIDDM (1995)

These data indicate that ACE gene polymorphism is associated with MI, but not with retinopathy or nephropathy, in patients with NIDDM and suggest that the ACE gene confers susceptibility to diabetic macroangiopathy but not to microangiopathy.
Biodegradable Fiber Reinforced Ti Composite Fabricated by Spark Plasma Sintering Method (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Perceptual organization in an interactive sketch editing application (2002)

The paper shows how techniques from computational vision can be deployed to support interactive sketch editing. While conventional computer supported drawing tools give users access to visible marks or image objects at a single level of abstraction, a human user's visual system rapidly constructs complex groupings and associations among image elements according to his or her immediate purposes. We have been exploring perceptually supported sketch editors in which computer vision algorithms run continuously, behind the scenes, to afford users efficient access to emergent visual objects in a drawing. We employ a flexible image interpretation architecture based on token grouping in a multiscale blackboard data structure. This organization supports multiple perceptual interpretations of line drawing data, domain specific knowledge bases for interpreting visual structures, and natural gesture based selection of visual objects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Molecular simulation of lignin-related aromatic compound permeation through gram-negative bacterial outer membranes (2022)

Lignin, an abundant aromatic heteropolymer in secondary plant cell walls, is the single largest source of renewable aromatics in the biosphere. Leveraging this resource for renewable bioproducts through targeted microbial action depends on lignin fragment uptake by microbial hosts and subsequent enzymatic action to obtain the desired product. Recent computational work has emphasized that bacterial inner membranes are permeable to many aromatic compounds expected from lignin depolymerization processes. In this study, we expand on these findings through simulations for 42 lignin-related compounds across a gram-negative bacterial outer membrane model. Unbiased simulation trajectories indicate that spontaneous crossing for the full outer membrane is relatively rare at molecular simulation timescales, primarily due to preferential membrane partitioning and slow diffusion within the lipopolysaccharide layer within the outer membrane. Membrane partitioning and permeability coefficients were determined through replica exchange umbrella sampling simulations to overcome sampling limitations. We find that the glycosylated lipopolysaccharides found in the outer membrane increase the permeation barrier to many lignin-related compounds, particularly the most hydrophobic compounds. However, the effect is relatively modest; at industrially relevant concentrations, uncharged lignin-related compounds will readily diffuse across the outer membrane without the need for specific porins. Together, our results provide insight into the permeability of the bacterial outer membrane for assessing lignin fragment uptake and the future production of renewable bioproducts.
A samarium(II) iodide promoted tandem radical cyclization. The total synthesis of (.+-.)-hypnophilin and the formal synthesis of (.+-.)-coriolin (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA samarium(II) iodide promoted tandem radical cyclization. The total synthesis of (.+-.)-hypnophilin and the formal synthesis of (.+-.)-coriolinThomas L. Fevig, Richard L. Elliott, and Dennis P. CurranCite this: J. Am. Chem. Soc. 1988, 110, 15, 5064–5067Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00223a026https://doi.org/10.1021/ja00223a026research-articleACS PublicationsRequest reuse permissionsArticle Views1924Altmetric-Citations159LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gene expression profiling of progressive and stable childhood pilocytic astrocytomas (2004)

8546
Study on Instantaneous Voltage Control Method for Auxiliary Power Supply Systems Used in Rolling Stocks. (1996)

Auxiliary power supply systems, or SIVs (Static Inverters), which feed electric loads in rolling stocks have been used instead of motor-generator systems (MGs), because they have many advantages over the MGs including weight, seize and ease of maintenance. Recently, SIVs using the IGBTs (Isolated Gate Bipolar Transistors) with high switching frequency have been developed, which are expected to achieve stable and high response of the output voltage. In the SIVs, it is needed to suppress resonance of LC filter which is connected to reduce harmonics of the output voltage. Therefore, in order to realize high response of the output voltage, instantaneous voltage control which can suppress the resonance is needed. This paper proposes a new instantaneous voltage control method for SIV, which can suppress the resonance of LC filter and achieve high response to disturbance without static error with simple structure of control system. Simulation results show effectiveness of the method.
Cameras in mobile phones (2006)

One of the fastest growing markets in consumer markets today are camera phones. During past few years total volume has been growing fast and today millions of mobile phones with camera will be sold. At the same time resolution and functionality of the cameras has been growing from CIF towards DSC level. From camera point of view the mobile world is an extremely challenging field. Cameras should have good image quality but in small size. They also need to be reliable and their construction should be suitable for mass manufacturing. All components of the imaging chain should be well optimized in this environment. Image quality and usability are the most important parameters to user. The current trend of adding more megapixels to cameras and at the same time using smaller pixels is affecting both. On the other hand reliability and miniaturization are key drivers for product development as well as the cost. In optimized solution all parameters are in balance but the process of finding the right trade-offs is not an easy task. In this paper trade-offs related to optics and their effects to image quality and usability of cameras are discussed. Key development areas from mobile phone camera point of view are also listed.
Adsorption of Cerium Salts and Cerium Oxide Nanoparticles on Microbubbles Can Be Induced by a Fluorocarbon Gas (2018)

Retrieving heavy metals from wastewaters has become an important environmental challenge. We report that exposing dilute aqueous solutions or dispersions of cerium compounds (CeO2, Ce(SO4)2, CeF4) to perfluorohexane-saturated air results in substantial adsorption of these salts at the air/water interface, as consistently reflected by a marked decrease in interfacial tension, as assessed by bubble-shape profile analysis tensiometry. No detectable adsorption is observed in the absence of the fluorocarbon. Adsorption to the interface is also achieved when, and only when, CeO2 nanoparticle dispersions are exposed to the fluorocarbon vapor. We also found that microbubbles could be generated in cerium salt solutions and CeO2 nanoparticle dispersions when they are formed in the presence of perfluorohexane-saturated air, without need for any surfactant or chelating agent. Optical microscopy, static light scattering, and ζ potential measurements were used to establish the ability for the fluorocarbon to induce the formation and stabilize these microbubbles. These findings could provide the basis for a new approach to heavy metal (including radioactive element) recovery and recycling from industrial and other effluents that would combine ionic flotation and fluorocarbon gas-driven adsorption on microbubbles. Extraction of critical raw materials from dilute solutions could also be considered.
A generic topology selection method for analog circuits demonstrated on the OTA example (2015)

A generic, knowledge-based method for automatic topology selection of analog circuits in a predefined analog reuse library is presented in this paper on the OTA (Operational Transconductance Amplifier) example. Analog circuits of a given circuit class are classified in a topology tree, where each node represents a specific topology. Child nodes evolve from their parent nodes by an enhancement of the parent node's topological structure. Topology selection is performed by a depth-first-search in the topology tree starting at the root node, thus checking topologies of increasing complexity. The decisions at each node are based on solving equations or - if this is not possible - on simulations. The search ends at the first (and thus the simplest) topology which can meet the specification after an adequate circuit sizing. The advantages of the generic, tree based topology selection method presented in this paper are shown in comparison to a pool selection method and to heuristic approaches. The selection is based on an accomplished chip investigation.
Visual Camera Re-Localization from RGB and RGB-D Images Using DSAC (2021)

We describe a learning-based system that estimates the camera position and orientation from a single input image relative to a known environment. The system is flexible w.r.t. the amount of information available at test and at training time, catering to different applications. Input images can be RGB-D or RGB, and a 3D model of the environment can be utilized for training but is not necessary. In the minimal case, our system requires only RGB images and ground truth poses at training time, and it requires only a single RGB image at test time. The framework consists of a deep neural network and fully differentiable pose optimization. The neural network predicts so called scene coordinates, i.e., dense correspondences between the input image and 3D scene space of the environment. The pose optimization implements robust fitting of pose parameters using differentiable RANSAC (DSAC) to facilitate end-to-end training. The system, an extension of DSAC++ and referred to as DSAC*, achieves state-of-the-art accuracy on various public datasets for RGB-based re-localization, and competitive accuracy for RGB-D based re-localization.
Open-source speech-processing platforms: An application example (2018)

Speedy assessment of frequency-importance functions for a variety of speech materials is possible with an Open-source Speech-Processing (OSP) platform. One such platform is that developed at the University of California San Diego. It provides real-time, six-band, processing of microphone input from ear-level transducer assemblies. This platform was used to provide normative data on a new consonant-contrast test developed for use in studies of hearing-aid self-fitting. Performance of young normally hearing adults was measured under various conditions of low-pass filtering. Because the UCSD system includes two sets of filters whose center and crossover frequencies differ by half an octave, it was possible to test with cut-off frequencies at half-octave intervals from 250 through 8000 Hz. Group mean composite contrast score, after correction for chance, fell to around 50% at a (6 dB) cut-off frequency of 660 Hz. With a cut-off frequency of 1 kHz, group-mean contrast scores were in the region of 30 to 35% for place and clustering, 70% for continuance, and over 90% for voicing. Determining the frequency-importance functions of various speech materials and speech features is just one example of the potential value of OSPs in hearing-science and hearing-aid research.