gebhart/patrepeval huggingface dataset:
Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules (2002)

Although platelets have been implicated in the pathogenesis of vascular diseases, little is known about factors that regulate interactions between platelets and the vessel wall under physiological conditions. The objectives of this study were to 1) define the contribution of nitric oxide (NO) to endotoxin (lipopolysaccharide, LPS)-induced platelet-endothelial cell (P/E) adhesion in murine intestinal venules and 2) determine whether the antiadhesive action of NO is mediated by soluble guanylate cyclase (sGC). Adhesive interactions between platelets and endothelial cells were monitored by intravital microscopy. LPS administration into control wild-type mice (WT) resulted in a >15-fold increase in P/E adhesion. Similar responses were observed using endothelial NO synthase (eNOS)-deficient platelets. However, treatment with the NO donor diethylenetriamine-nitric oxide (DETA-NO) attenuated the P/E adhesion response to LPS, whereas the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester or eNOS deficiency resulted in an exacerbation. P/E adhesion response did not differ between LPS-treated WT and inducible NOS-deficient mice. Inhibition of sGC abolished the attenuating effects of DETA-NO, whereas the sGC activator 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) reduced LPS-induced P/E adhesion. These findings indicate that 1) eNOS-derived NO attenuates endotoxin-induced P/E adhesion and 2) sGC is responsible for the antiadhesive action of NO.
Pulmonary Hypertension and Risk of Death in Cardiomyopathy (2002)

Baseline mPA is particularly important for stratifying risk in myocarditis. These findings suggest that secondary pulmonary hypertension may have different biological features in myocarditis and that patients with pulmonary hypertension and myocarditis should be targeted for aggressive medical therapy.
The Influence of Hapten Size and Hydrophobicity on the Catalytic Activity of Elicited Polyclonal Antibodies (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Influence of Hapten Size and Hydrophobicity on the Catalytic Activity of Elicited Polyclonal AntibodiesMichael B. Wallace and Brent L. IversonView Author Information Department of Chemistry and Biochemistry The University of Texas at Austin Austin, Texas 78712 Cite this: J. Am. Chem. Soc. 1996, 118, 1, 251–252Publication Date (Web):January 10, 1996Publication History Received21 July 1995Published online10 January 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9524311https://doi.org/10.1021/ja9524311rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views214Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Biopolymers,Catalytic activity,Hydrophobicity,Immunology,Peptides and proteins Get e-Alerts
Drug Compliance in the Elderly. (1992)

In order to clarify the characteristics of elderly patients concerning their attitudes toward taking prescribed medicine, self-reported compliance with prescriptions was compared among different age groups. We performed a survey in 626 outpatients and their attending physicians in 4 of our affiliated hospitals, and analyzed self-reported compliance by the patients to the prescription and their answers to questions related to drug-taking along with the diagnoses and prescriptions reported by the physician. The number of prescribed medicine was 2.3 tablets on the average for patients younger than 40, while 5.1 tablets were prescribed for patients over 70. However, self-reported compliance was best in patients over 70 than in other age groups. Compliance was good in 76% of patients who answered that the amount of medicine was appropriate, while good compliance was lower in those who thought the prescription excessive (67%). Likewise, compliance of patients who had concerns with drug side effects or who were not feeling well under medication was lower than that of patients who felt well under medication. Prescriptions for after lunch were most liable to be forgotten than those for other times of the day. Moreover, a high percentage of elderly patients attended more than 2 departments or medical facilities, and one third of those patients did not inform the physician of the fact suggesting that they were at higher risks of overdosing and unexpected drug interaction. Furthermore, the percentage of patients who did not receive explanation from physicians was higher in the elderly thus demonstrating that elderly patients have quite different characteristics in attitude with regard to medicine from younger age group patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Patterns of intraneural ganglion cyst descent (2008)

On the basis of the principles of the unifying articular theory, predictable patterns of proximal ascent have been described for fibular (peroneal) and tibial intraneural ganglion cysts in the knee region. The mechanism underlying distal descent into the terminal branches of the fibular and tibial nerves has not been previously elucidated. The purpose of this study was to demonstrate if and when cyst descent distal to the articular branch-joint connection occurs in intraneural ganglion cysts to understand directionality of intraneural cyst propagation. In Part I, the clinical records and MRIs of 20 consecutive patients treated at our institution for intraneural ganglion cysts (18 fibular and two tibial) arising from the superior tibiofibular joint were retrospectively analyzed. These patients underwent cyst decompression and disconnection of the articular branch. Five of these patients developed symptomatic cyst recurrence after cyst decompression without articular branch disconnection which was done elsewhere prior to our intervention. In Part II, five additional patients with intraneural ganglion cysts (three fibular and two tibial) treated at other institutions without disconnection of the articular branch were compared. These patients in Parts I and II demonstrated ascent of intraneural cyst to differing degrees (12 had evidence of sciatic nerve cross-over). In addition, all of these patients demonstrated previously unrecognized MRI evidence of intraneural cyst extending distally below the level of the articular branch to the joint of origin: cyst within the proximal most portions of the deep fibular and superficial fibular branches in fibular intraneural ganglion cysts and descending tibial branches in tibial intraneural ganglion cysts. The patients in Part I had complete resolution of their cysts at follow-up MRI examination 1 year postoperatively. The patients in Part II had intraneural recurrences postoperatively within the articular branch, the parent nerve, and the terminal branches, although in three cases they were subclinical. The authors demonstrate that cyst descent distal to the take-off of the articular branch to the joint of origin occurs regularly in patients with fibular and tibial intraneural ganglion cysts. The authors believe that parent terminal branch descent follows ascent up the articular branch from an affected joint of origin. This mechanism for bidirectional flow explains cyst within terminal branches of the fibular and tibial nerves and is dependent on pressure fluxes and resistances. This new pattern is consistent with principles previously described in a unified (articular) theory, is generalizable to other intraneural ganglion cysts arising from joints, and has important implications for pathogenesis and treatment of these intraneural cysts.
New construction of Costas sequences (1989)

A new construction of Costas sequences, based on the logarithm of the linear congruence function over GF(p), when p is prime, is presented. It is shown that for every prime p, the set of p−1 Costas sequences of length p−1 can be generated.
A formal model of the Document Object Model (2018)

In this AFP entry, we formalize the core of the Document Object Model (DOM). At its core, the DOM defines a tree-like data structure for representing documents in general and HTML documents in particular. It is the heart of any modern web browser. Formalizing the key concepts of the DOM is a prerequisite for the formal reasoning over client-side JavaScript programs and for the analysis of security concepts in modern web browsers. We present a formalization of the core DOM, with focus on the node-tree and the operations defined on node-trees, in Isabelle/HOL. We use the formalization to verify the functional correctness of the most important functions defined in the DOM standard. Moreover, our formalization is 1) extensible, i.e., can be extended without the need of re-proving already proven properties and 2) executable, i.e., we can generate executable code from our specification.
Evaluation of performance enhancing proxies in internet over satellite (2003)

Abstract Performance enhancing proxies (PEPs) are widely used to improve the performance of TCP over high delay‐bandwidth product links and links with high error probability. In this paper we analyse the performance of using TCP connection splitting in combination with web caching via traces obtained from a commercial satellite system. We examine the resulting performance gain under different scenarios, including the effect of caching, congestion, random loss and file sizes. We show, via analysing our measurements, that the performance gain from using splitting is highly sensitive to random losses and the number of simultaneous connections, and that such sensitivity is alleviated by caching. On the other hand, the use of a splitting proxy enhances the value of web caching in that cache hits result in much more significant performance improvement over cache misses when TCP splitting is used. We also compare the performance of using different versions of HTTP in such a system. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Keratinocytes inhibit expression of connective tissue growth factor in vitro by an interleukin-1α-dependent mechanism (2002)

In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. Previous studies suggest that keratinocytes downregulate the production of collagen and profibrotic factors in fibroblasts. We hypothesized that keratinocytes downregulate the expression of the profibrotic factor connective tissue growth factor (CTGF) in fibroblasts, and regulate fibroblast expression of genes important to wound healing. In keratinocyte-fibroblast cocultures, keratinocytes downregulated CTGF mRNA and protein in fibroblasts, through the secretion of interleukin-1 (IL-1) α. Using Affymetrix DNA microarrays, it was demonstrated that factors from keratinocytes regulate the expression of 69 genes important to wound healing. The regulation of 16 of these genes was confirmed by Northern blotting, and IL-1α from keratinocytes regulated all the 16 genes examined. IL-1-mediated CTGF gene regulation was further investigated. Both IL-1 isoforms, α and β, suppressed CTGF expression through an inhibition of CTGF promoter activity. Interestingly, transforming growth factor-β-stimulated Smad phosphorylation was not affected by IL-1. Finally, we hypothesized that CTGF is downregulated in burn wound by split-thickness skin grafting and that the expression of CTGF is suppressed during reepithelialization. The expression of CTGF protein was decreased in successfully skin-grafted wound areas, and increased in open, granulating burn wounds. Moreover, CTGF protein expression was absent beneath the migrating edge of reepithelialization ex vivo. In conclusion, we demonstrate that, in in vitro models, keratinocyte-derived IL-1α regulates the expression of CTGF and other genes with importance to wound healing. Furthermore, it is shown that CTGF expression is suppressed by epidermal wound coverage i burn wounds. These findings may have implications for the understanding of keratinocyte-fibroblast interplay during wound healing and in hypertrophic scar pathogenesis.
25 Jahre retikuläre Chemie (2021)

Abstract Im Wesentlichen hat die retikuläre Chemie die Präzision und Expertise der organischen und anorganischen Synthese auf den festen Zustand übertragen. Während die anfängliche Aufregung über Metall‐organische Gerüstverbindungen (MOFs) und kovalente organische Gerüstverbindungen (COFs) zweifellos durch ihre beispiellose Porosität und Oberfläche befeuert wurde, war die tiefgreifendste wissenschaftliche Innovation des Feldes die Ausarbeitung von Designstrategien für die Synthese von erweiterten kristallinen Festkörpern durch starke gerichtete Bindungen. In diesem Aufsatz beleuchten wir die verschiedenen Klassen von retikulären Materialien, die entwickelt worden sind, wie solche Gerüstverbindungen funktionalisiert werden können und wie Komplexität in ihr Grundgerüst eingeführt werden kann. Schließlich zeigen wir, wie die strukturelle Kontrolle über diese Materialien von der molekularen Skala über ihre Kristallmorphologie und Form auf der Nanoskala bis hin zu ihrer Gestaltung auf der Bulk‐Skala erweitert wird.
Polarization dependence of light intensity distribution from nanometer metallic slits (2004)

In this work, the near-field and far-field electric magnetic (EM) wave distributions of metallic slits was observed using tapered fiber probe and modelled using finite difference time domain (FDTD) computer simulations. The EM wave field distribution from rectangular slits with widths 100 nm, 300 nm, and 500 nm was mapped with excitation wavelength /spl lambda/ = 532 nm. /spl lambda//2 can be considered a characteristic length for the problem. From the experiments and FDTD simulation, E/sub /spl perp// wave is found to be governed by the surface plasmon wave (SPW) which results in ill near field pattern and cannot be confined in the slit. On the contrary, E/sub /spl par// wave has a well-shaped field distribution and can be confined in the slit.
Quantifying Response in a Class of Nonlinear Sensors with a Noise-Floor (2009)

Oscillations in unidirectionally coupled overdamped bistable systems are, now, known to occur when a control parameter is swept through a critical value. Here, we use a protype device—the Coupled Core Fluxgate Magnetometer (CCFM)‐ as an example system and demonstrate how its response, quantified by a suitably defined non‐spectral figure of merit, can be quantified in the presence of a noise floor.
Über Sauerstoffradikale, XXIV. Untersuchungen an Selen‐haltigen Aroxylen mittels der Elektronenresonanz (1962)

Abstract Es wird die Herstellung von Lösungen Selen‐haltiger Aroxyle beschrieben und mit Hilfe von EPR‐Spektren versucht, die mesomeren Grenzzustände dieser Radikale festzulegen. Unter besonderen Bedingungen gelingt es, in einigen Spektren die Kopplung zwischen dem Einzelelektron und dem 77 Se aufzufinden, so daß es sich bei den vorliegenden Verbindungen um mesomere Sauerstoff‐Kohlenstoff‐Selenradikale handelt.
CCDC 640414: Experimental Crystal Structure Determination (2007)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The Power and Potential of Doxorubicin‐DNA Adducts (2005)

Abstract Doxorubicin (trade name Adriamycin) is a widely used anticancer agent which exhibits good activity against a wide range of tumors. Although the major mode of action appears to be normally as a topoisomerase II poison, it also exhibits a number of other cellular responses, one of which is the ability to form adducts with DNA. For adduct formation doxorubicin must react with cellular formaldehyde to form an activated Schiff base which is then able to form an aminal (N‐C‐N) linkage to the exocyclic amino group of guanine residues. The mono‐adducts form primarily at G of 5'‐GCN‐3' sequences where the chromophore of the drug is intercalated between the C and N base pair. The structure of the adducts has have been well defined by 2D NMR, mass spectrometry and X‐ray crystallography. The formation of these anthracycline adducts in cells grown in culture has been unequivocally demonstrated. The source of formaldehyde in cells can be endogenous, provided by coadministration of prodrugs that release formaldehyde or by prior complexation of anthracyclines with formaldehyde. Since the adducts appear to be more cytotoxic than doxorubicin alone, and also less susceptible to drug‐efflux forms of resistance, they offer new approaches to improving the anticancer activity of the anthracyclines. IUBMB Life, 57: 73‐81, 2005
Comparison between the midamble and the hopping-pilots schemes for estimation of the downlink mobile channel. (2003)

Two possible modifications to the downlink IEEE 802.16a OFDM FFT-256 PHY have been proposed to tackle the issue of estimating the time -varying mobile channel - one is to insert midamble symbols every several 'regular' symbols, the other is to use the already existing pilots by varying their location from symbol to symbol. The document compares the performance, in terms of signal-to-noise ratio, of the two schemes. It is shown that the hopping-pilots scheme outperforms the midamble scheme while requiring no additional overhead. Purpose The document is submitted for consideration in the 802.16e WG. Notice This document has been prepared to assist IEEE 802.16. It is offered as a basis for discussion and is not binding on the contributing individual(s) or organization(s). The material in this document is subject to change in form and content after further study. The contributor(s) reserve(s) the right to add, amend or withdraw material contained herein. Release The contributor grants a free, irrevocable license to the IEEE to incorporate material contained in this contribution, and any modifications thereof, in the creation of an IEEE Standards publication; to copyright in the IEEE's name any IEEE Standards publication even though it may include portions of this contribution; and at the IEEE's sole discretion to permit others to reproduce in whole or in part the resulting IEEE Standards publication. The contributor also acknowledges and accepts that this contribution may be made public by IEEE 802.16. Patent
Charge-Based Separation of Micro- and Nanoparticles (2020)

Deterministic Lateral Displacement (DLD) is a label-free particle sorting method that separates by size continuously and with high resolution. By combining DLD with electric fields (eDLD), we show separation of a variety of nano and micro-sized particles primarily by their zeta potential. Zeta potential is an indicator of electrokinetic charge-the charge corresponding to the electric field at the shear plane-an important property of micro- and nanoparticles in colloidal or separation science. We also demonstrate proof of principle of separation of nanoscale liposomes of different lipid compositions, with strong relevance for biomedicine. We perform careful characterization of relevant experimental conditions necessary to obtain adequate sorting of different particle types. By choosing a combination of frequency and amplitude, sorting can be made sensitive to the particle subgroup of interest. The enhanced displacement effect due to electrokinetics is found to be significant at low frequency and for particles with high zeta potential. The effect appears to scale with the square of the voltage, suggesting that it is associated with either non-linear electrokinetics or dielectrophoresis (DEP). However, since we observe large changes in separation behavior over the frequency range at which DEP forces are expected to remain constant, DEP can be ruled out.
AFM-Induced Amine Deprotection:  Triggering Localized Bond Cleavage by Application of Tip/Substrate Voltage Bias for the Surface Self-Assembly of Nanosized Dendritic Objects (2004)

An alpha,alpha-dimethyl-3,5-dimethoxybenzyloxycarbonyl (DDZ)-protected amine monolayer can be selectively deprotected by the application of a voltage bias from a conducting AFM tip to afford localized nanoscale patterns that can be visualized by self-assembly of dendritic molecular objects with terminal carboxylic acid groups and different aspect ratios.
Reservation mechanisms for efficient resource management in internetworks (2002)

Distributed multimedia applications with quality of service requirements that must be guaranteed by the underlying network are evolving at a fast pace. Resource reservation protocols are therefore essential to enable efficient resource management in internetworks. We survey existing resource reservation protocols and the reservation styles they support. Current protocols do not permit different reservation styles to be combined within the same session. We show, using simulation of realistic scenarios, that allowing different reservation styles to coexist within the same session yields more efficient resource management and provides more satisfactory service to the applications. We then propose a complete mechanism for implementing the shared dynamic reservation style, along with three techniques to enhance its effectiveness in managing the network resources. The effectiveness of these three techniques is evaluated using simulation.
Intrachannel versus Interchannel Application of Angiogenic Factors in Transmyocardial Laser Revascularization (2001)

In this porcine model, the addition of a bovine bone derived growth factor mixture to TMLR significantly stimulates angiogenesis in the areas adjacent to the channels. The place of injection does not influence the angiogenesis intensity.