gebhart/patrepeval huggingface dataset:
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas (2019)

Squamous cell carcinoma (SCC), a malignancy arising across multiple anatomical sites, is responsible for significant cancer mortality due to insufficient therapeutic options. Here, we identify exceptional glucose reliance among SCCs dictated by hyperactive GLUT1-mediated glucose influx. Mechanistically, squamous lineage transcription factors p63 and SOX2 transactivate the intronic enhancer cluster of SLC2A1. Elevated glucose influx fuels generation of NADPH and GSH, thereby heightening the anti-oxidative capacity in SCC tumors. Systemic glucose restriction by ketogenic diet and inhibiting renal glucose reabsorption with SGLT2 inhibitor precipitate intratumoral oxidative stress and tumor growth inhibition. Furthermore, reduction of blood glucose lowers blood insulin levels, which suppresses PI3K/AKT signaling in SCC cells. Clinically, we demonstrate a robust correlation between blood glucose concentration and worse survival among SCC patients. Collectively, this study identifies the exceptional glucose reliance of SCC and suggests its candidacy as a highly vulnerable cancer type to be targeted by systemic glucose restriction.
Fast Functionalisation of Polypropylene (Pp) by Ultraviolet Irradiation and Compatibilised Pp/Caco3 Composite (2008)

Some oxygen-containing groups such as C–O and C=O were quickly introduced onto polypropylene (PP) chains by ultraviolet irradiation at high light intensity and high environmental temperature in air. The content of the groups increased with increasing time of ultraviolet irradiation. There was no gel in ultraviolet-irradiated PP. Compared with those of unirradiated PP, the crystal form and the phase space of ultraviolet-irradiated PP did not change, but its melt temperature decreased, and its crystallinity, liquidity and hydrophilicity increased. The ultraviolet-irradiated PP used as compatibiliser was melt blended with PP and CaCO 3 , and a PP/irradiated PP/CaCO 3 composite was prepared. Compared with those of PP/CaCO 3 composite, the compatibility and dispersion of the PP/irradiated PP/CaCO 3 composite were improved, and its tensile strength and notched impact strength were increased.
Infrared Studies on the Grafting Reactions of Poly(vinyl alcohol) (1990)

The emulsion copolymerization of vinyl acetate and butyl acrylate with poly(vinyl alcohol) of different degrees of hydrolysis as the sole emulsifier was studied. The grafting reactions of the poly(vinyl alcohol) and the vinyl acetate in the aqueous phase affect the rates of individual monomer consumption and the overall polymerization kinetics. The copolymer products of this grafting reaction were analyzed by Fourier transform infrared (FTIR) spectroscopy. A limiting value for the amount of vinyl acetate grafting to the poly(vinyl alcohol) to maintain water solubility was determined.
Distributed Multiscale Data Analysis and Processing for Sensor Networks (2005)

While multiresolution data analysis, processing, and compression hold considerable promise for sensor network applications, progress has been confounded by two factors.First, typical sensor data are irregularly spaced, which is incompatible with standard wavelet techniques.Second, the communication overhead of multiscale algorithms can become prohibitive.In this paper, we take a first step in addressing both shortcomings by introducing two new distributed multiresolution transforms.Our irregularly sampled Haar wavelet pyramid and telescoping Haar orthonormal wavelet basis provide efficient piecewise-constant approximations of sensor data.We illustrate with examples from distributed data compression and in-network wavelet de-noising.
Screw Removal Can Resolve Unexplained Anterior Pain Without Recurrence of Shoulder Instability After Open Latarjet Procedures (2020)

The present findings confirm that unexplained anterior pain after Latarjet procedures can be related to the screws used to fix bone blocks, which can safely be alleviated or reduced by screw removal.
Oxidative Dissolution of Copper and Zinc Metal in Carbon Dioxide with tert-Butyl Peracetate and a β-Diketone Chelating Agent (2004)

A series of beta-diketone ligands, R(1)COCH(2)COR(2) [tmhdH (R(1) = R(2) = C(CH(3))(3)); tfacH (R(1) = CF(3); R(2) = CH(3)); hfacH (R(1) = R(2) = CF(3))], in combination with tert-butyl peracetate (t-BuPA), have been investigated as etchant solutions for dissolution of copper metal into carbon dioxide solvent. Copper removal in CO(2) increases in the order tfacH < tmhdH < hfacH. A study of the reactions of the hfacH/t-BuPA etchant solution with metallic copper and zinc was conducted in three solvents: scCO(2) (supercrical CO(2)); hexanes; CD(2)Cl(2). The etchant solution/metallic zinc reaction produced a diamagnetic Zn(II) complex, which allowed NMR identification of the t-BuPA decomposition products as tert-butyl alcohol and acetic acid. Gravimetric analysis of the amount of zinc consumed, together with NMR studies, confirmed the 1:1:2 Zn:t-BuPA:hfacH reaction stoichiometry, showing t-BuPA to be an overall two-electron oxidant for Zn(0). The metal-containing products of the copper and zinc reactions were characterized by elemental analysis, IR spectroscopy, and, as appropriate, NMR spectroscopy and single-crystal X-ray diffraction [trans-M(hfac)(2)(H(2)O)(CH(3)CO(2)H) (1, M = Cu; 2, M = Zn)]. On the basis of the experimental results, a working model of the oxidative dissolution reaction is proposed, which delineates the key chemical variables in the etching reaction. These t-BuPA/hfacH etchant solutions may find application in a CO(2)-based chemical mechanical planarization (CMP) process.
Eyeriss v2: A Flexible and High-Performance Accelerator for Emerging Deep Neural Networks (2018)

The design of DNNs has increasingly focused on reducing the computational complexity in addition to improving accuracy. While emerging DNNs tend to have fewer weights and operations, they also reduce the amount of data reuse with more widely varying layer shapes and sizes. This leads to a diverse set of DNNs, ranging from large ones with high reuse (e.g., AlexNet) to compact ones with high bandwidth requirements (e.g., MobileNet). However, many existing DNN processors depend on certain DNN properties, e.g., a large number of channels, to achieve high performance and energy efficiency and do not have sufficient flexibility to efficiently process a diverse set of DNNs. In this work, we present Eyexam, a performance analysis framework that quantitatively identifies the sources of performance loss in DNN processors. It highlights two architectural bottlenecks in many existing designs. First, their dataflows are not flexible enough to adapt to the varying layer shapes and sizes of different DNNs. Second, their network-on-chip (NoC) can't adapt to support both high data reuse and high bandwidth scenarios. Based on this analysis, we present Eyeriss v2, a high-performance DNN accelerator that adapts to a wide range of DNNs. Eyeriss v2 has a new dataflow, called Row-Stationary Plus (RS+), that enables the spatial tiling of data from all dimensions to fully utilize the parallelism for high performance. To support RS+, it has a low-cost and scalable NoC design, called hierarchical mesh, that connects the high-bandwidth global buffer to the array of processing elements (PEs) in a two-level hierarchy. This enables high-bandwidth data delivery while still being able to harness any available data reuse. Compared with Eyeriss, Eyeriss v2 has a performance increase of 10.4x-17.9x for 256 PEs, 37.7x-71.5x for 1024 PEs, and 448.8x-1086.7x for 16384 PEs on DNNs with widely varying amounts of data reuse.
Initial testing of JNJ‐26854165 (Serdemetan) by the pediatric preclinical testing program (2011)

JNJ-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. In vitro, JNJ-26854165 demonstrated cytotoxic activity. The ALL cell line panel had a significantly lower median IC(50) (0.85 µM) than the remaining cell lines. In vivo JNJ-26854165 induced significant differences in EFS distribution compared to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable ALL xenografts. Objective responses were observed in 4 of 37 solid tumor xenografts, and 2 of 7 ALL xenografts achieved PR or CR. Responses were noted in xenografts with both mutant and wild-type p53.
High dose gamma irradiation effects on properties of active layers in ZnO thin film transistors (2021)

Abstract Solution-based bottom-gate zinc oxide thin film transistors (TFTs) were fabricated, remaining functional and demonstrating stability under extreme gamma irradiation conditions. Unpassivated TFTs were fabricated on samples with different number of ZnO layers grown via sol-gel spin coating technique. The devices were characterized before and after exposure to a cumulative dose of 220 MRad (air) of gamma irradiation. Atomic force microscopy (AFM), x-ray diffraction (XRD), and photoluminescence (PL) were employed to characterize the TFT active layers. Thickness measurements and optical images suggest the removal of the channel surface, conceivably due to cumulative effect of displacement damage near the ZnO surface. Device electrical characteristics were extracted from current–voltage measurements. The impact of displacement damage on the degradation/enhancement of device characteristics as a consequence of surface/bulk effects is discussed.
Parallel algorithms for the circuit value update problem (1995)

Article Parallel algorithms for the circuit value update problem Share on Authors: Charles E. Leiserson MIT Laboratory for Computer Science, 545 Technology Square, Cambridge, MA MIT Laboratory for Computer Science, 545 Technology Square, Cambridge, MAView Profile , Keith H. Randall MIT Laboratory for Computer Science, 545 Technology Square, Cambridge, MA MIT Laboratory for Computer Science, 545 Technology Square, Cambridge, MAView Profile Authors Info & Claims SPAA '95: Proceedings of the seventh annual ACM symposium on Parallel algorithms and architecturesJuly 1995 Pages 13–20https://doi.org/10.1145/215399.215406Published:20 July 1995 1citation245DownloadsMetricsTotal Citations1Total Downloads245Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
“Sounding” out crystal nuclei—A mathematical-physical and experimental investigation (2023)

We outline techniques for the control and measurement of the nucleation of crystalline materials. Small angle x-ray scattering/wide angle x-ray scattering x-ray diffraction measurements are presented that demonstrate the impact of low power, continuous, non-cavitational ultrasound on the nucleation and crystallization of a wax-n-eicosane dissolved in a heptane/toluene solvent. A mathematical-physical approach based on the rectification of heat and mass transport by such a low power oscillating pressure field is outlined, and it is suggested that this approach be combined with dissipative particle dynamics computational modeling to develop a predictive method capable of modeling the impact of low power oscillating pressure fields (acoustics and ultrasonics) on a wide range of nucleating systems. Combining the ultrasound pitch and catch speed of sound measurements with low power harmonically oscillating pressure fields to monitor and control nucleation presents the prospect of entirely new industrially significant methods of process control in crystallization. It also offers new insights into nucleation processes in general. However, for the acoustic control technique to be widely applied , further theoretical and modeling work will be necessary since, at present, we are unable to predict the precise effect of low power ultrasound in any given situation.
A DNN Based Post-Filter to Enhance the Quality of Coded Speech in MDCT Domain (2022)

Frequency domain processing, and in particular the use of Modified Discrete Cosine Transform (MDCT), is the most widespread approach to audio coding. However, at low bitrates, audio quality, especially for speech, degrades drastically due to the lack of available bits to directly code the transform coefficients. Traditionally, post-filtering has been used to mitigate artefacts in the coded speech by exploiting a-priori information of the source and extra transmitted parameters. Recently, datadriven post-filters have shown better results, but at the cost of significant additional complexity and delay. In this work, we propose a mask-based post-filter operating directly in MDCT domain of the codec, inducing no extra delay. The real-valued mask is applied to the quantized MDCT coefficients and is estimated from a relatively lightweight convolutional encoder-decoder network. Our solution is tested on the recently standardized low-delay, low-complexity codec (LC3) at lowest possible bitrate of 16 kbps. Objective and subjective assessments clearly show the advantage of this approach over the conventional post-filter, with an average improvement of 10 MUSHRA points over the LC3 coded speech.
Applications of Multidirectional Asymmetrical Microlens-Array Light-Control Films on Reflective Liquid-Crystal Displays for Image Quality Enhancement (2004)

The multidirectional asymmetrical microlens-array light-control film (MAMA-LCF) is developed for enhancing the image brightness and contrast ratio of various reflective liquid-crystal displays. By use of index-matching material, the interface reflection is greatly reduced. Through optimized designs, the surface-scattering effect is also suppressed; thus the contrast ratio is much enhanced. From experimental results, the MAMA-LCF leads to a approximately 1.5 x gain in brightness over the MgO standard white and a 15:1 contrast ratio for the reflective color super-twist nematic liquid-crystal display, 2.8 x MgO and a 23:1 contrast ratio for the polymer-dispersed liquid-crystal, and 2.8 x MgO and a 13:1 contrast ratio for the cholesteric liquid-crystal display. Potential applications of this low-cost plastic thin film for reflective liquid-crystal displays are foreseeable.
Paeonins A and B, Lipoxygenase Inhibiting Monoterpene Galactosides from Paeonia emodi. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Observation of New Resonances Decaying to J/ψK+ and J/ψϕ (2021)

The first observation of exotic states with a new quark content cc[over ¯]us[over ¯] decaying to the J/ψK^{+} final state is reported with high significance from an amplitude analysis of the B^{+}→J/ψϕK^{+} decay. The analysis is carried out using proton-proton collision data corresponding to a total integrated luminosity of 9 fb^{-1} collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV. The most significant state, Z_{cs}(4000)^{+}, has a mass of 4003±6_{-14}^{+4} MeV, a width of 131±15±26 MeV, and spin parity J^{P}=1^{+}, where the quoted uncertainties are statistical and systematic, respectively. A new 1^{+} X(4685) state decaying to the J/ψϕ final state is also observed with high significance. In addition, the four previously reported J/ψϕ states are confirmed and two more exotic states, Z_{cs}(4220)^{+} and X(4630), are observed with significance exceeding 5 standard deviations.
Designing organic phosphine oxide host materials using heteroarmatic building blocks: inductive effects on electroluminescence (2007)

Phosphine oxide substitution of small molecules with high triplet exciton energies allows development of vacuum sublimable, electron transporting host materials for blue OLEDs. Heteroaromatic building blocks (carbazole, dibenzofuran and dibenzothiophene) with E<sub>T</sub> ~ 3 eV were incorporated into phosphine oxide (PO) structures. External quantum efficiencies (EQEs) at lighting brightness (i.e., 800 cd/m<sup>2</sup>) reached as high as 9.8% at 5.2V for OLEDs using the heteroaromatic PO hosts doped with the sky blue phosphor, iridium(III)bis(4,6-(di-fluorophenyl)-pyridinato-<i>N,C</i><sup>2,</sup>) picolinate (FIrpic). Comparing device properties at a similar current density (i.e., J = 13 mA/cm<sup>2</sup>) showed the dibenzothiophene-bridged PO compound exhibits the highest EQEs and lowest operating voltages at all phosphor dopant levels. These results are explained with respect to the effects of the inductive phosphine oxide substituents on electrochemical, photophysical and electroluminescence properties of the substituted heteroaromatic building blocks.
Femtosecond Arrival Time Stability of Pump Probe Laser System at the FLASH Free Electron Laser (2020)

The arrival time of the burst-mode OPCPA laser system for XUV–NIR pump-probe experiments at the XUV free-electron laser FLASH was characterized. After 40 m beam transport to the experimental endstation we measured a fluctuation of 7.8 fs rms and 134 fs p-p in a 5 min and 24 hour period, respectively
Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs (2016)

Abstract Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β‐amino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To expand this potential utility to include systemic delivery of mRNA, hybrid polymer–lipid nanoformulations for systemic delivery to the lungs were developed. Through coformulation of PBAEs with lipid–polyethylene glycol (PEG), mRNA formulations were developed with increased serum stability and increased in vitro potency. The formulations were capable of functional delivery of mRNA to the lungs after intravenous administration in mice. To our knowledge, this is the first report of the systemic administration of mRNA for delivery to the lungs using degradable polymer–lipid nanoparticles.
Ultra high switching speed 600 V thin wafer PT-IGBT based on new turn-off mechanism (2003)

A new turn-off mechanism for 600 V thin wafer PT-IGBTs (punch-through IGBTs) has been found and ultra high speed switching has been demonstrated, for the first time, in this paper. The new turn off process makes it possible to operate IGBTs in a quasi-MOSFET mode in the turn-off transient, realizing ultra high speed switching. Most of the stored carriers in the n-drift region can be automatically removed, without any additional means, in the storage time period, before the voltage recovery process. This results in extremely low dissipated power loss and substantially eliminates tail current. Furthermore, this paper described the results of numerical investigation and measured characteristics of the sustaining mode operation. When the p-emitter efficiency of thin wafer PT-IGBTs was decreased, the sustaining voltage was larger than the static breakdown voltage and most of the current was supplied by impact ionization due to poor p-n-p transistor action. Thin wafer PT-IGBTs with reduced p-emitter efficiency behave like quasi-MOSFETs.
VEGF Expression and Receptor Activation in the Choroid during Development and in the Adult (2006)

The observations suggest that VEGF signaling is involved, not only in choroidal vessel formation, but perhaps also in the maintenance of the choriocapillaris.
Impact of Baseline Hemodynamics on the Effects of a Transcatheter Interatrial Shunt Device in Heart Failure With Preserved Ejection Fraction (2018)

Background Interatrial shunt device (IASD) effects have been described in patients with heart failure and ejection fractions (EFs) ≥40%. However, baseline characteristics that correlate with greatest hemodynamic effects are unknown. On the basis of fundamental principles, we hypothesized that larger pressure gradients between left and right atria would yield greater shunt flow and greater hemodynamic effects. Methods and Results REDUCE LAP-HF (Reduce Elevated Left Atrial Pressure in Patients With Heart Failure) was a multicenter study that investigated IASD safety and performance. Sixty-four patients with EF ≥40% underwent device implantation followed by hemodynamic assessments at rest and exercise, including pulmonary capillary wedge pressure (PCWP, surrogate for left atrial pressure) and central venous pressure (CVP). At 6 months, IASD resulted in an average pulmonary-to-systemic blood flow ratio of 1.27 and increased exercise tolerance. The PCWP-CVP gradient (ie, the driving pressure for shunt flow) decreased at peak exercise from 16.8±6.9 to 11.4±5.5 mm Hg, because of increased CVP (17.5±5.4 to 20.3±7.9 mm Hg; P=0.04) and decreased PCWP (34.1±7.6 to 31.6±8.0 mm Hg; P=0.025). Baseline PCWP-CVP gradient during exercise correlated with changes of both PCWP-CVP and PCWP: Δ(PCWP-CVP)=10.0-0.89·(PCWP-CVP)<sub>baseline</sub> ( r<sup>2</sup>=0.56) and ΔPCWP=7.54-0.60·(PCWP-CVP)<sub>baseline</sub> ( P=0.001). Hemodynamics of patients with EF ≥50% and those with EF <50% responded similarly to IASD. Conclusions In heart failure patients with EF ≥40%, IASD significantly reduced PCWP and PCWP-CVP at peak exercise. Patients with higher baseline PCWP-CVP gradient had greater reductions in both parameters at follow-up. Results were sustained through 12 months and were independent of whether EF was ≥50% or between 40% and 49%. Additional studies will help further define the baseline hemodynamic predictors of exercise, hemodynamic, and clinical efficacy of the IASD. Clinical Trial Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT01913613.
Forcing function models for structures excited by low-speed flow (2000)

Predictions of flow-induced flat plate vibrations using a finite-element structural model and the modified Corcos cross-spectral model as the forcing function [Hambric and Hwang, Proceedings of Inter-Noise 2000, Nice, France, 27–30 August (2000)] agree very well with the measured [Han et al., J. Sound Vib. 227(4), 685–709 (1999)] plate vibrations. However, extremely fine finite-element meshes had to be used to resolve the streamwise variations of the coherence function. This approach is not computationally tractable for most large complex structures. This paper discusses a practical approach of utilizing an approximated discrete forcing function model, which represents only the low-wavenumber region of the excitation in terms of the cross-spectra of grid forces. The high-wavenumber (convective ridge) content of the excitation is thus ignored. This method is believed more feasible in practice because the finite-element meshes now need only resolve the structural wave scale instead of the convective turbulence scale. This approximated forcing function model is assessed against the exact model and found to be satisfactory in most cases except when the structural mode wavenumbers are close to the convective ridge. [Work supported by ONR, Code 333.]
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality (2021)

The NLRP3 intronic variant rs10754555 is associated with increased systemic inflammation, inflammasome activation, prevalent coronary artery disease, and mortality. This study provides evidence for a substantial role of genetically driven systemic inflammation in CVD and highlights the NLRP3 inflammasome as a therapeutic target.