gebhart/patrepeval huggingface dataset:
Design of a rehabilitation device based on a mechanical link system (2009)

Realizing an ideal impedance control system in lower extremity rehabilitation systems is challenged by mechanical impedance of robot hardware. Although some studies in the field of control systems have been helpful in reducing the mechanical impedance of actuators, they have not been able to remove the inertia of robot hardware. This paper introduces an alternative design in which mechanical links are utilized. The mechanical links are driven by one actuator without any complicated servo systems. The design parameters are optimized for the link system to generate the normal walking motion. The simulation data shows that the normal gait patterns are realized successfully. The device is connected to a patient using elastic components, and therefore the inertia of the robot is not directly imposed on the patient. The patient's legs are guided to follow the motion of the robot with the forces generated by the elastic components.
Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with BRAF V600-mutated Metastatic Melanoma (2019)

These findings suggest that enriched immune infiltration might be a shared feature favoring response to both targeted and immune therapies, while features of innate resistance to targeted and immune therapies were distinct.
Transient complexes of redox proteins: structural and dynamic details from NMR studies (2004)

Redox proteins participate in many metabolic routes, in particular those related to energy conversion. Protein-protein complexes of redox proteins are characterized by a weak affinity and a short lifetime. Two-dimensional NMR spectroscopy has been applied to many redox protein complexes, providing a wealth of information about the process of complex formation, the nature of the interface and the dynamic properties of the complex. These studies have shown that some complexes are non-specific and exist as a dynamic ensemble of orientations while in other complexes the proteins assume a single orientation. The binding interface in these complexes consists of a small hydrophobic patch for specificity, surrounded by polar, uncharged residues that may enhance dissociation, and, in most complexes, a ring or patch of charged residues that enhances the association by electrostatic interactions. The entry and exit port of the electrons is located within the hydrophobic interaction site, ensuring rapid electron transfer from one redox centre to the next.
Design, construction, and initial performance of SciBar detector in K2K experiment (2005)

A new near detector for the K2K long baseline neutrino experiment, the SciBar, was constructed and started data taking to study neutrino interactions. In K2K, neutrino oscillation is studied by comparing the number of neutrino interactions and energy spectrum between near and far detectors. In order to study neutrino oscillations more precisely, it is necessary to improve the measurement of neutrino spectrum and interactions below 1 GeV, where the latest K2K results suggest maximum oscillation. For that purpose, SciBar is designed to be fully active with fine segmentation. We present the design and basic performance. All detector components have been working as expected. Also presented are the measurements of charged current interactions which are used in the latest K2K oscillation analysis.
Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity (2011)

78 kDa glucose-regulated protein (Grp78) is a heat shock protein (HSP) involved in protein folding that plays a role in cancer cell proliferation. Binding of adenosine-derived inhibitors to Grp78 was characterized by surface plasmon resonance and isothermal titration calorimetry. The most potent compounds were 13 (VER-155008) with KD = 80 nM and 14 with KD = 60 nM. X-ray crystal structures of Grp78 bound to ATP, ADPnP, and adenosine derivative 10 revealed differences in the binding site between Grp78 and homologous proteins.
In Situ Transmission Electron Microscopy Observation of 3C-SiC Heteroepitaxial Growth on Si Nanomembrane (2022)

Journal Article In Situ Transmission Electron Microscopy Observation of 3C-SiC Heteroepitaxial Growth on Si Nanomembrane Get access Kangsik Kim, Kangsik Kim Center for Multidimensional Carbon Materials, Institute for Basic Science (IBS), Ulsan, Republic of Korea Search for other works by this author on: Oxford Academic Google Scholar Seungwoo Son, Seungwoo Son Center for Multidimensional Carbon Materials, Institute for Basic Science (IBS), Ulsan, Republic of KoreaSchool of Materials Science and Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea Search for other works by this author on: Oxford Academic Google Scholar Seonwoo Lee, Seonwoo Lee School of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea Search for other works by this author on: Oxford Academic Google Scholar Jong-Hyun Ahn, Jong-Hyun Ahn School of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea Search for other works by this author on: Oxford Academic Google Scholar Zonghoon Lee Zonghoon Lee Center for Multidimensional Carbon Materials, Institute for Basic Science (IBS), Ulsan, Republic of KoreaSchool of Materials Science and Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea Corresponding author: zhlee@unist.ac.kr Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 28, Issue S1, 1 August 2022, Pages 1832–1833, https://doi.org/10.1017/S1431927622007218 Published: 01 August 2022
Document page classification algorithms in low-end copy pipeline (2008)

We develop real-time, low-complexity image classification algorithms suitable for a copy mode selector embedded in a low-end copier. The algorithms classify scanned images represented in RGB or in an opponent color space. Classes are the eight combinations of mono/color and text/mix/picture/photo. Classification is 30–98% accurate with misclassifications tending to be benign. The algorithms provide for improved copy quality, a simplified user interface, and increased copy rate.
Optimal Battery Energy Storage Dispatch in Energy and Frequency Regulation Markets While Peak Shaving an EV Fast Charging Station (2022)

Battery Energy Storage Systems typically procure their primary revenues from regulated energy and ancillary services markets; nonetheless, they have great potential in supporting distribution network operators and their users. This paper evaluates the potential business case of battery storage systems integrating market application and services to a photovoltaic assisted electric vehicle fast-charging station. A mathematical deterministic optimization problem is formulated using mixed-integer linear programming to combine battery storage system operation in the day-ahead and frequency regulation market and the remunerated services offered to the charging station. The technical and economic feasibility of the solution and the applicability of the proposed framework is verified through a case study reflecting an existing photovoltaic assisted charging station in the Netherlands and considering the Dutch energy market framework and prices. The study shows that such battery storage system implementation is economically and technically advantageous for the players involved. The battery storage system can stack additional revenues on top of the market revenues. The charging station benefits from a reduced peak power and a 30% tariff reduction, and the system operator would indirectly benefit from the shaved charging station profile. Furthermore, the analysis shows that providing services to the charging station from the battery storage system does not significantly impact its market-related revenues.
Tumor Microenvironment and Immune Effector Cells: Isolation, Large Scale Propagation and Characterization of CD8+ Tumor Infiltrating Lymphocytes From Renal Cell Carcinomas (2020)

Metastatic renal cell cancer has been one of the malignancies in focus for therapeutic attempts with such in vitro expanded tumor infiltrating lymphocytes (TIL). This chapter discusses a monoclonal antibody and device-based technology, developed by Applied Immune Sciences, has been used to capture CD8+ subpopulations present in renal cell carcinoma-derived TIL. Renal cell carcinoma samples were obtained from resected kidneys post-surgery after obtaining patient informed consent. Cells from bulk-cultured TIL were concentrated, and each device was loaded with the concentrated bulk cultured TIL. The non-adherent fraction was removed and the capture surface rinsed leaving the desired cells on the surface. The first phase of TIL production involved lymphocyte cultivation from whole tumor digest. Initial lymphocyte composition was highly variable, ranging from 27% to 70% immediately post-digestion. A significant correlation was also found between the antitumor cytotoxicity and the number of days that the CD8+ TIL culture was propagated ex vivo.
Randomized Phase II and Pharmacogenetic Study of Pemetrexed Compared With Pemetrexed Plus Carboplatin in Pretreated Patients With Advanced Non–Small-Cell Lung Cancer (2009)

PC as second-line treatment for relapsed NSCLC resulted in a significant 33% reduction of the hazard of disease progression as compared with pemetrexed alone.
Multiparametric Ultrasound for Prostate Cancer Detection and Localization: Correlation of B-mode, Shear Wave Elastography and Contrast Enhanced Ultrasound with Radical Prostatectomy Specimens (2019)

Multiparametric ultrasound of the prostate, consisting of B-mode, shear wave elastography and contrast enhanced ultrasound with parametric maps, improved localization and index lesion detection of clinically significant prostate cancer compared to single ultrasound modalities, yielding good sensitivity.
Smart pixel architecture for low power CMOS image sensor: Time-to-first spike with inhibition mechanism (2017)

In this paper, we present an image acquisition mechanism fitting the constraints of an advanced technology, FDSOI 28nm, while featuring low power consumption. This technique relies on reducing the data throughput of the image sensor by suppressing a part of the spatial redundancies in a pseudo asynchronous acquisition. The proposed architecture is firstly validate through a MATLAB model, then a corresponding design is presented. The power target is under 100μW for a 128-by-128 image sensor.
Liquid crystal based phase shifters in 60 GHz band (2010)

Preliminary structures and performance results of two different 60 GHz band planar phase shifters using liquid crystal (LC) are presented. The first phase shifter is based on a meandered microstrip line structure with the conductor pattern exposed to a layer of a nematic LC, while the second phase shifter is based on the reflection type microstrip line phase shifter structure whose tunable reflective loads are formed on a nematic LC substrate. The LC used in these two phase shifters is E7 with a low temperature coefficient over a wide range of temperatures. In both phase shifters, the LC is biased through a variable low voltage external source allowing for the control of the dielectric constant of the LC. To facilitate the on-wafer measurement and the application of the electric field to the LC, a broadband transition from the microstrip line to the CPW is developed and used in both phase shifters. The best figure of merit of the meandered line phase shifter, 20.8° dB, occurs at 60.7 GHz coinciding with a differential phase shift of 243 degrees, while the RTPS achieves a maximum figure of merit, 12.3° dB, at 61.31 GHz corresponding to a differential phase shift of 170 degrees.
Minor ginsenoside F1 improves memory in APP/PS1 mice (2019)

Ginseng has been shown to produce a cognitive improvement effect. The key molecular components in ginseng that produce pharmacological effects are ginsenosides. Previous studies reported a memory improvement effect of a few major ginsenosides. However, the identity of specific minor ginsenosides mediating such function remains unknown. Here, we report that a minor ginsenoside F1 improves memory function in APPswe/PSEN1dE9 (APP/PS1) double-transgenic Alzheimer's disease (AD) model mice. After 8-wk oral administration of F1 jelly, we observed that spatial working memory, but not context-dependent fear memory, was restored in AD mice. To search for a possible underlying molecular and cellular mechanism, we investigated the effect of F1 on Aβ plaque. We observed F1 administration reduced the Aβ plaque area and density in the cortex, but not in the hippocampus of AD mice. Next, we tested for the effect of F1 on the expression level of key molecules involved in learning and memory. Results from Western blot assay revealed that an abnormally reduced level of a phosphorylated form of CREB in the hippocampus of AD mice was restored to a normal level by F1 administration. Moreover, in the same animals, BDNF level was augmented in the cortex. Our results, therefore, suggest that minor ginsenoside F1 constitutes a promising target to develop therapeutic agents for AD.
Nernstian Adsorbate-like Bulk Layer of Organic Radical Polymers for High-Density Charge Storage Purposes (2008)

Redox polymer layers with 2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl (TEMPO) groups showed nernstian adsorbate-like electrochemical behaviors up to submicrometer thicknesses, based on a fast charge propagation within the bulk layer and persistency in electrolyte solutions.
Thermal energy barrier distribution measurements in perpendicular media (2002)

dc demagnetized remanent curves at different applied field time durations have been applied to measure the thermal energy barrier distribution of two sets of perpendicular alloy media. Sharrock’s formula is applied at all levels of percentages of magnetization switching. The measured energy barrier distribution width decreases with increasing intergranular exchange coupling and with reducing intergranular magnetostatic interactions. The results agree well with micromagnetic simulations.
Commande prédictive des systèmes hybrides. Application à la commande de systèmes en électronique de puissance (2014)

Groupe de Travail Systèmes Hybrides (SHY) du GDR MACS, ENSTA ParisTech, Palaiseau, France
Process Optimization Using OPE-Master and CDU Master (2013)

OPE matching and CD-Uniformity control have become inevitable steps for most of high volume manufacturing(HVM) of a state-of-the-art devices. OPE matching is a step to match CDs of various patterns from different scanners or steppers. CD-Uniformity control is to stabilize CDs across exposure fields, across wafers and across lots, for HVMs. At a current OPE matching, one usually collects tool properties from each matching tool and import them into simulation software they are using to improve its prediction accuracy. However, generally speaking, this is a time and human resource consuming process, because data acquisition from scanners usually take a lot of time of both human and machine. Furthermore, what makes it more difficult is that an OPE matching, in most cases, requires several iterations. In this paper, we will introduce our latest software named OPE-Master. By employing the software, we can expect following merits. Firstly, with the help of the software, one can be able to automatically import machine properties. This means we can expedite the iterations without sacrifice of the accuracy. Secondly, one can also be able to get better solutions, because it uses all possible adjustment knobs, some of which are ones that unable to be accessed by a third party softwares, with the help of newly developed optimization algorithm that uses a hybrid method of nonlinear optimization and rigorous simulation. Finally, intuitive interface of the software makes it possible for an engineer without much optical simulation experiences to do an OPE matching simulation. In this paper, we will also introduce one of our latest software, called CDU-Master, which will be used to control CD uniformities for a HVM. CDU-Master can analys CDs from various metrology tools, such as, CD-SEMs, OCDs or a macro inspection tools(AMI, for example). CDU-Master can decompose CD errors into focus and dose errors and then derives parameters to correct CDs. One can expect extremely high accuracy of the decomposition, because, CD-SEM as an example, it uses all possible information such as CDs and pattern 3D structure information. The correction parameters, which may include very high order coefficients to be able to deal with very high spatial frequency distribution of errors across a field or across a wafer, will be converted into a format that can be recognized by scanners and then can be exported to scanners automatically, by the software.
Mobile multimedia services (2005)

This panel will mainly focus on the role that media processing can play in creating mobile communications, information, and entertainment services. A major premise of our discussion is that media processing techniques go beyond compression and can be employed to monitor, filter, convert, and repurpose information. Such automated techniques can serve to create personalized information and entertainment services in a cost-effective way, adapt existing content for consumption on mobile devices, and circumvent the inherent limitations of mobile devices. Some examples of the applications of media processing techniques for mobile service generation will be given.
Stress dependence and effect of plastic deformation on magnetic hysteresis and anhysteretic magnetization of FeNi32% films (2007)

The magnetic hysteresis and anhysteretic magnetization of FeNi32% films were investigated as a function of isotropic stress. The magnetostriction contribution to dc magnetization under elastic stress and the effect of the plastic strain on the hysteresis loops are discussed. Also, a role of the plastic deformation interrelated with the elastic stress in the magnetization process is established. An experimental system based on a conventional vibrating sample magnetometer equipped with a specially designed loading fixture and optical resonant spectroscopy tension monitoring technique are used to measure anhysteretic permeability and magnetization curve as a function of stress. Measurements of magnetostriction as a function of magnetic field were shown to be also possible using this fixture. Stresses are deduced from the characteristic resonant frequency of the sample in the fixture and verified via pulse propagation velocity measurement. Both indirect stress measurements are contactless, relying on remote vibration measurement using a laser Doppler vibrometer. Uniaxial stresses up to 1GPa can be applied for samples down to 50μm specimens. Anhysteretic permeability was extracted from the anhysteretic B-H curves constructed by degaussing the sample at the given longitudinal (parallel to the stresses) dc field. The large positive magnetostriction constant leads to higher susceptibility and lower coercivity with tensile stress while the large volume magnetostriction results in reduced saturation magnetization. Large stresses imposed on the sample result in plastic strain of the sample which induces increase in dislocation density and domain wall pinning. This causes the gain in hysteresis loss and coercivity to increase at the highest stresses.
Charge transport, optical transparency, microstructure, and processing relationships in transparent conductive indium–zinc oxide films grown by low-pressure metal-organic chemical vapor deposition (1998)

Indium–zinc oxide films (ZnxInyOx+1.5y), with x/y=0.08–12.0, are grown by low-pressure metal-organic chemical vapor deposition using the volatile metal–organic precursors In(TMHD)3 and Zn(TMHD)2 (TMHD=2,2,6,6–tetramethyl–3,5–heptanedionato). Films are smooth (rms roughness=40–50 Å) with complex microstructures which vary with composition. The highest conductivity is found at x/y=0.33, with σ=1000 S/cm (n-type; carrier density=3.7×1020 cm3; mobility=18.6 cm2/V s; dσ/dT&amp;lt;0). The optical transmission window of such films is broader than Sn-doped In2O3, and the absolute transparency rivals or exceeds that of the most transparent conductive oxides. X-ray diffraction, high resolution transmission electron microscopy, microdiffraction, and high resolution energy dispersive X-ray analysis show that such films are composed of a layered ZnkIn2O3+k phase precipitated in a cubic In2O3:Zn matrix.
Characteristics of familial isolated pituitary adenomas (2007)

The familial occurrence of pituitary adenomas has been recognized for many years and currently accounts for approximately 5% of all cases. Molecular, genetic and clinical features of familial pituitary adenomas have been well characterized in multiple endocrine neoplasia type 1 (MEN-1) and Carney's complex (CNC), which account for the majority of familial pituitary tumor cases. These conditions are caused by MEN1 and PRKAR1A gene mutations, respectively, and the clinical and pathological features of pituitary pathology in these diseases differ from those of sporadic pituitary tumors. Familial acromegaly has been recognized for many years and, more recently, the clinical features of this clinical phenotype, referred to as isolated familial somatotropinoma, have been clarified. Over the past decade, the concept of non-MEN-1/CNC familial pituitary tumors has been expanded significantly to include all phenotypes, a condition known as familial isolated pituitary adenomas (FIPA). In FIPA, tumors can present homogeneously (same phenotype) or heterogeneously (different tumor phenotypes) within the same family. Compared with sporadic pituitary adenomas, patients with FIPA have a younger age at diagnosis and have larger tumors. The clinical features of FIPA differ from those of MEN-1 in terms of a higher frequency of somatotropinomas and a lower frequency of prolactinomas. The recent discovery of the involvement of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in association with pituitary tumors has provided new information regarding potential mechanisms of tumorigenesis in FIPA patients. While very infrequent in sporadic pituitary tumors, approximately 15% of FIPA patients have AIP mutations, rising to half of patients with familial acromegaly. In this review, we detail the clinical features of FIPA and discuss tumor pathology and genetic findings in this increasingly recognized clinical condition.
Oxazole (2014)

[288-42-6] C3H3NO (MW 69.07) 1S/C3H3NO/c1-2-5-3-4-1/h1-3H InChIKey = ZCQWOFVYLHDMMC-UHFFFAOYSA-N (2-aza Diels–Alder diene,2 precursor to N-formylformamide3) Physical Data: mp −87 to −84 °C; bp 69–70 °C; d 1.050 g cm−3; λmax 205 nm (ε 3900). Form Supplied in: colorless oil. Preparative Methods: two methods have been reported for the preparation of oxazole.4, 5 The more recent approach entails three steps (eqs 1 and 2) and an overall yield of 39%. (1) (2)