gebhart/patrepeval huggingface dataset:
Association between Homesickness and the Related Factors with Happiness in the Dormitory Students of Hamadan University of Medical Sciences, Iran (2018)

Background and objectives: Admission to university is an important event in the life of youth in every country. Homesickness is one of the most significant issues faced by university students during their education life. The present study aimed to determine the association between homesickness, happiness and the related factors in the dormitory students in Hamadan University of Medical Sciences, Iran. Methods: This cross-sectional, descriptive-analytical study was conducted on 387 dormitory students at Hamedan University of Medical Sciences in Hamedan, Iran during February-March 2015. Subjects were selected via stratified random sampling with proportional allocation. Data were collected using self-report and using demographic and contextual questionnaires, Fenfelit homesickness questionnaire, and oxford happiness questionnaire. Data analysis was performed in SPSS version 23 using Pearson's correlation-coefficient and general linear model (GLM) at the significance level of 0.05.
EUV lithography introduction at Chipmakers (2011)

With the 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> NXE:3100, 0.25NA and 0.8σ conventional illumination, being operational at a Semiconductor Manufacturer, we enter the next phase in EUVL implementation. Since 2006 process and early device verification has been done using the two Alpha Demo Tools (ADT's) located at Leuven, Belgium at IMEC and Albany, New York, USA. Now process integration has started at actual Chipmakers sites. This is a major step for the development and implementation of EUVL. The focus is now on the integration of EUVL exposure tools, along with the rest of lithographic infrastructure such as mask, resist, and computational litho tools, into a manufacturing flow, preparing high volume EUVL manufacturing expected to start in late 2012. Fore high volume manufacturing with EUV, we will update on the design status of the NXE:3300B being introduced in 2012 with a productivity target of 125wph. Featuring a 0.33NA lens and off-axis illumination at full transmission, a half pitch resolution from 22nm to 16nm can be supported.
Further weight reduction of applications in long glass reinforced polymers (2014)

Long glass reinforced materials are broadly used in the automotive industry due to their good mechanical performance, competitive price and options for functional integration in order to reduce weight. With rapidly changing environmental requirements, a demand for further weight reduction is growing constantly. Designs in LGF-PP can bring light weight solutions in combination with system cost improvement. There are quite some possibilities for applying weight reduction technologies nowadays. These technologies have to be evaluated based on weight reduction potential, but also on mechanical performance of the end application, where the latter is often the key to success. Different weight reduction technologies are applied to SABIC®STAMAX{trade mark, serif} material, a long glass fiber reinforced polypropylene (LGF-PP), in order to investigate and define best application performance. These techniques include: chemical foaming, physical foaming and thin wall applications. Results from this research will be presented, giving a guideline for your development.
Coherent DSP and System Integration Technologies for 800G (2022)

This paper discusses challenges in achieving low-power coherent pluggables for 800G, and innovations required to overcome those challenges. Recent progress in the areas of system integration and low-power DSP design and implementation will be surveyed.
Vesiculovirus Neutralization by Natural IgM and Complement (2014)

Oncolytic virotherapy is a promising approach for the treatment of disseminated cancers, but antibody neutralization of circulating oncolytic virus particles remains a formidable barrier. In this work, we developed a pseudotyped vesicular stomatitis virus (VSV) with a glycoprotein of Maraba virus, a closely related but serologically distinct member of the family Rhabdoviridae, which demonstrated greatly diminished susceptibility to both nonimmune and VSV-immune serum neutralization. VSV with Maraba G substituted or lentiviral vectors should therefore be further investigated as candidates for human systemic oncolytic virotherapy and gene therapy applications.
Cancer-specific chromosome alterations in the constitutive fragile region FRA3 B (1999)

We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6. 2%), and it apparently does not harbor other genes. In a detailed analysis of the 308-kilobase region between FHIT exon 5 and the telomeric end of intron 3, a region known to encompass a human papillomavirus-16 integration site and two clusters of aphidicolin-induced chromosome 3p14.2 breakpoints, we have precisely mapped 10 deletion and translocation endpoints in cancer-derived cell lines relative to positions of specific repetitive elements, regions of high genome flexibility and aphidicolin-induced breakpoints. Conclusions are (i) that aphidicolin-induced breakpoint clusters fall close to high-flexibility sequences, suggesting that these sequences contribute directly to aphidicolin-induced fragility; (ii) that 9 of the 10 FHIT allelic deletions in cancer cell lines resulted in loss of exons, with 7 deletion endpoints near long interspersed nuclear elements or long terminal repeat elements; and (iii) that cancer-specific deletions encompass multiple high-flexibility genomic regions, suggesting that fragile breaks may occur at these regions, whereas repair of the breaks involves homologous pairing of flanking sequences with concomitant deletion of the damaged fragile sequence.
Phase II Clinical Trial of Robotic Stereotactic Body Radiosurgery for Metastatic Gynecologic Malignancies (2012)

Case Comprehensive Cancer Center.
General chairs' message (2015)

It has been our great pleasure to extend a warm welcome to all the attendees of the 9th IEEE International Conference on Advanced Networks and Telecommunications Systems (IEEE ANTS 2015) held in Indian Statistical Institute, Kolkata during December 15–18, 2015. In the previous three years, IEEE ANTS was held in Bangalore (2012), Chennai (2013) and Delhi (2014). We hope that IEEE ANTS continued its tradition of providing a forum for fruitful exchange of ideas among the participants from academia, government organizations and industry coming from different countries of the world.
Meta-gradient boosted decision tree model for weight and target learning (2016)

Labeled training data is an essential part of any supervised machine learning framework. In practice, there is a trade-off between the quality of a label and its cost. In this paper, we consider a problem of learning to rank on a large-scale dataset with low-quality relevance labels aiming at maximizing the quality of a trained ranker on a small validation dataset with high-quality ground truth relevance labels. Motivated by the classical Gauss-Markov theorem for the linear regression problem, we formulate the problems of (1) reweighting training instances and (2) remapping learning targets. We propose meta-gradient decision tree learning framework for optimizing weight and target functions by applying gradient-based hyperparameter optimization. Experiments on a large-scale real-world dataset demonstrate that we can significantly improve state-of-the-art machine-learning algorithms by incorporating our framework.
Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer (2019)

Tumors from younger and older patients with colorectal cancer demonstrated similar overall rates of genomic alteration. However, differences were noted in several genes relevant to biology and response to therapy. Further study will need to be conducted to determine whether the differences in gene alteration rates can be leveraged to provide personalized therapies for young patients with early-onset sporadic colorectal cancer.
Digital I/Q imbalance compensation in low-IF receivers: principles and practice (2003)

The current emphasis in radio transceiver design is on technologies suitable for integration on a single silicon chip. In order to simplify the receiver analog front-end and, thus, to enhance the receiver integrability, I/Q signal processing has received growing research interest. In practical analog implementations, the main barrier is vulnerability to amplitude and phase mismatches. We discuss the possibilities of using novel digital signal processing (DSP) techniques to unravel the I/Q imbalance effects. Two digital mismatch compensation algorithms are explored and analyzed using measured low-IF receiver front-end signals. Based on the obtained results, the studied algorithms can provide sufficient compensation performance also in practical operation environments, reinforcing the confidence in digital imbalance compensation techniques.
A 15 MHz &#x2013; 600 MHz, 20 mW, 0.38 mm<sup>2</sup>, fast coarse locking digital DLL in 0.13&#x03BC;m CMOS (2008)

A digital delay-locked-loop (DLL) suitable for generation of multiphase clocks in applications such as time-interleaved and pipelined ADCs locks in a very wide (40X) frequency range. The DLL provides 12 uniformly delayed phases that are free of false harmonic locking. The digital control loop has two stages: a fast-locking coarse acquisition is achieved in four cycles using binary search; a fine linear loop achieves low jitter (8.9 ps rms @ 600 MHz) and tracks PVT variations. The DLL consumes 20 mW and occupies a 470 μm X 800 μm area in 0.13μm CMOS.
Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin (2001)

This paper summarizes the peculiarities of HPMA copolymer-bound doxorubicin as an anticancer drug. It was found that polymer-bound doxorubicin demonstrated higher anticancer activity compared with free doxorubicin. This phenomenon was explained by the following mechanisms of its anticancer action: preferential accumulation in tumors, internalization in membrane-limited organelles, ability to overcome existing multidrug resistance and not to induce it de novo, high intracellular toxicity and inhibition of detoxification enzymes, cell death induction by the activation of specific signaling pathways, and triggering of caspase activation cascades.
Cyclic Melanotropins. 9. 7-D-Phenylalanine Analogues of the Active-Site Sequence (1985)

The cyclic melanotropin Ac-Ser1-Tyr2-Ser3-Cys4-Glu5-His6-Phe7-Arg8 -Trp9-Cys10-Lys11-Pro12-Val13-NH is a highly potent agonist as determined in several melanocyte bioassays. In linear melanotropins, a D-Phe7 substitution leads to increased potency and often prolonged biological activity. In order to determine if this substitution would have the same effect in cyclic melanotropins, we have prepared a series of these analogues. The D-Phe7-substituted cyclic melanotropins Ac-[Cys4,D-Phe7,Cys10]-alpha-MSH4-10-NH2 and Ac-[Cys4,D-Phe7,Cys10]-alpha-MSH4-11-NH2 were both more potent than their cyclic L-Phe7-containing counterparts in either the frog or lizard skin bioassay by more than a factor of 10. Neither peptide, however, exhibited prolongation of biological activity in either assay. Substitution of D-Phe7 into the cyclic 4-12 and 4-13 sequences led to a slight or no increase in potency in both assays relative to the L-Phe7 counterparts, but the activity of the melanotropins was ultraprolonged in each assay. Ac-[Cys4,D-Phe7,Cys10]-alpha-MSH4-12-NH2 was about equipotent to Ac-[Cys4,D-Phe7,Cys10]-alpha-MSH4-13-NH2, again demonstrating, as with certain linear and cyclic L-Phe7-containing melanotropins, that the C-terminal amino acid valine is not required for biological activity or for superpotency. Similar to the linear D-Phe7 analogues that possessed ultraprolonged melanotropic activity, the 4-12 and 4-13 cyclic D-Phe7 analogues also displayed the phenomenon of superagonism, which is a time-dependent increase in efficacy over that produced by an equipotent concentration of the native hormone. Cyclization of certain linear melanotropins resulted in analogues with increased resistance to biological degradation by serum enzymes or purified proteolytic enzymes. Further, incorporation of a D-Phe7 into in the cyclic analogues led to melanotropins that were totally resistant to enzymatic inactivation by trypsin.
Contrast of the Biological Activity of Negatively and Positively Charged Microwave Synthesized CdSe/ZnS Quantum Dots (2011)

Quantum dots (QDs) are semiconductor nanocrystals that have found use in bioimaging, cell tracking, and drug delivery. This article compares the cytotoxicity and cellular interactions of positively and negatively charged CdSe/CdS/ZnS QDs prepared by a microwave method using a murine alveolar macrophage-like cell culture model. Keeping the core semiconductor the same, QD charge was varied by altering the surface capping molecule; negatively charged QDs were formed with mercaptopropionic acid (MPA-QDs) and positively charged QDs with thiocholine (THIO-QDs). The size and charge of these two QDs were investigated in three types of media (RPMI, RPMI + FBS, and X-VIVO serum-free media) relevant for the biological studies. MPA-QDs were found to have negative zeta potential in RPMI, RPMI + FBS, and serum-free media and had sizes ranging from 8 to 54 nm. THIO-QDs suspended in RPMI alone were <62 nm in size, while large aggregates (greater than 1000 nm) formed when these QDs were suspended in RPMI + FBS and serum-free media. THIO-QDs retained positive zeta potential in RPMI and were found to have a negative zeta potential in RPMI + FBS and nearly neutral zeta potential in serum-free media. In a cell culture model, both MPA-QDs and THIO-QDs caused comparable levels of apoptosis and necrosis. Both QDs induced significant tumor necrosis factor-alpha (TNF-α) secretion only at high concentrations (>250 nM). Both types of QDs were internalized via clathrin-dependent endocytosis. Using real-time, live cell imaging, we found that MPA-QDs interact with the cell surface within minutes and progress through the endocytic pathway to the lysosomes upon internalization. With the THIO-QDs, the internalization process was slower, but the pathways could not be mapped because of spectroscopic interference caused by QD aggregates. Finally, MPA-QDs were found to associate with cell surface scavenger receptors, while the THIO-QDs did not. This study indicates that the surface charge and aggregation characteristics of QDs change drastically in biological culture conditions and, in turn, influence nanoparticle and cellular interactions.
All solid-state, 8-12 µm continuously tunable DIAL laser transmitter with patterncontrollable, rapid wavelength switching (2003)

The first demonstration of a fieldable, 8-12 µm continuously tunable, all solid-state DIAL laser transmitter is reported. The 24″ × 24″ × 8″ unit generates 10 kW pulses and can switch between two wavelengths in any pattern at 120 Hz.
Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells (2002)

IFN regulatory factor (IRF)-4 is a lymphoid/myeloid-restricted member of the IRF transcription factor family that plays an essential role in the homeostasis and function of mature lymphocytes. IRF-4 expression is tightly regulated in resting primary T cells and is transiently induced at the mRNA and protein levels after activation by Ag-mimetic stimuli such as TCR cross-linking or treatment with phorbol ester and calcium ionophore (PMA/ionomycin). However, IRF-4 is constitutively upregulated in human T cell leukemia virus type I (HTLV-I) infected T cells as a direct gene target for the HTLV-I Tax oncoprotein. In this study we demonstrate that chronic IRF-4 expression in HTLV-I-infected T lymphocytes is associated with a leukemic phenotype, and we examine the mechanisms by which continuous production of IRF-4 is achieved in HTLV-I-transformed T cells. IRF-4 expression in HTLV-1-infected cells is driven through activation of the NF-kappaB and NF-AT pathways, resulting in the binding of p50, p65, and c-Rel to the kappaB1 element and p50, c-Rel, and NF-ATp to the CD28RE element within the -617 to -209 region of the IRF-4 promoter. Furthermore, mutation of either the kappaB1 or CD28RE sites blocks Tax-mediated transactivation of the human IRF-4 promoter in T cells. These experiments constitute the first detailed analysis of human IRF-4 transcriptional regulation within the context of HTLV-I infection and transformation of CD4(+) T lymphocytes.
Degradatie van de dentinehechting, te voorkomen met MMP-inhibitoren? (2009)

Doelstelling: Ets&spoel adhesieven demineraliseren het dentine volledig tot 5 µm diep. De vrijgelegde collageenvezels vormen samen met het adhesief hars de hybride laag, die zorgt voor de retentie van de composietvulling. Tijdens de applicatie van fosforzuur worden eveneens MatrixMetalloproteïnasen (MMP’s) vrijgezet (Pashley e.a., 2004). Deze enzymen kunnen collageenvezels afbreken en zo de hechting op termijn hypothekeren. Materiaal&Methode: Een twee- en drie-stappen ets&spoel adhesief (respectievelijk Scotchbond 1 XT, 3M-ESPE en OptiBond FL, Kerr) werden aangebracht op dentinevlakken geprepareerd van recent geëxtraheerde wijsheidstanden. Vervolgens werd het adhesief aangebracht en een opbouw in composiet (Clearfil APX, Kuraray) vervaardigd. Na 1 week, 3, 6 en 12 maanden werd de microtreksterkte bepaald en de degradatie van de hechting ultra-morfologisch geëvalueerd m.b.v. transmissie- en scanning elektronenmicroscopie. Stockage van de micro-specimens in 10% natriumhypochloriet (NaOCl) fungeerde als ‘worst-case-scenario’, omdat voorgaand onderzoek heeft aangetoond dat zo’n behandeling de hechting uiterst snel aantast. Deze test werd herhaald na toevoeging van 2 verschillende MMP-inhibitoren aan de respectievelijke primers: 1) chloorhexidine, een niet-specifieke MMP-inhibitor, maar wel al veelvuldig toegepast in de tandheelkunde; 2) SB-3CT, een zeer specifieke MMP-inhibitor, maar niet geschikt voor toepassing in vivo. Resultaten: De hechtsterkte van beide adhesieven was significant (twee-weg ANOVA met herhaalde metingen, p<0.0001) gedaald na 12 maanden stockage in water. Na 12 maanden was vooral de hechting van het twee-stappen ets&spoel adhesief onvoldoende, getuige het grote aantal falingen voor de eigenlijke microtreksterktetest. De twee inhibitoren hadden een gelijkaardig effect, maar dit was verschillend voor beide adhesieven. Voor het drie-stappen ets&spoel adhesief was er een mild positief effect, terwijl er voor het twee-stappen ets&spoel adhesief een duidelijk negatief effect was. Conclusie: MMP-inhibitoren kunnen in bepaalde gevallen de hechting aan dentine over lange termijn verbeteren, maar het effect is beperkt en geldt slechts voor bepaalde adhesieven. Deze studie bevestigt andermaal dat de traditionele drie-stappen aanpak met een aparte etsgel, primer en adhesief hars effectiever is dan een ‘vereenvoudigde’ twee-stappen benadering met een gecombineerde primer/adhesief hars, ondanks dat op korte termijn bijna geen verschil genoteerd werd.
PIN detector arrays and integrated readout circuitry on high-resistivity float-zone silicon (1994)

A new silicon pin-diode-based pixel detector for ionizing particles integrating a two-dimensional array of detecting elements with readout circuitry has been developed and extensively tested. The signal charge is collected on a low-capacitance electrode avoiding loss of charge into the local readout circuitry within each pixel. The spatial resolution for a given circuitry size is optimized. The approach required back side patterning of the wafer, the only nonconventional part in the Stanford BiCMOS based manufacturing process. Thirteen masks on the front side of the wafer and three on the back yielded both CMOS readout circuitry and detecting elements. A gettering step helped obtain a high minority carrier lifetime (500 /spl mu/s). Test results obtained by infrared illumination, gamma rays, and high-energy particles, which have been described in detail elsewhere, are summarized. They include a signal to single-channel-noise performance of about 150 to 1 for a minimum ionizing particle, which is an order of magnitude better than silicon strip detectors currently used, and a record-breaking spatial resolution in the direction of smallest pixel pitch (standard deviation of about 1.8 /spl mu/m). We describe the device and chip operation of the new detector in detail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88) (2023)

&lt;p&gt;PDF file - 407K&lt;/p&gt;
All-dimensional subwavelength cavities made with metamaterials (2006)

By exploiting the reflection phase properties of metamaterial reflectors, the authors propose a method to break the size restrictions imposed strictly on conventional cavities. They design the all-dimensional subwavelength cavities and perform experiments and simulations to demonstrate their subwavelength functionalities. For the smallest cavity that they fabricated, each dimension is only a quarter of the resonance wavelength.
Model-based reconstruction for x-ray diffraction imaging (2016)

In this paper, we propose a novel 4D model-based iterative reconstruction (MBIR) algorithm for low-angle scatter X-ray Diffraction (XRD) that can substantially increase the SNR. Our forward model is based on a Poisson photon counting model that incorporates a spatial point-spread function, detector energy response and energy-dependent attenuation correction. Our prior model uses a Markov random field (MRF) together with a reduced spectral bases set determined using non-negative matrix factorization. We demonstrate the effectiveness of our method with real data sets.
Figure S15 from Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody (2023)

&lt;p&gt;Supplementary Figure 15 shows no body weight changes in response to sasanlimab treatment in mice.&lt;/p&gt;
Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial (2009)

Adjuvant treatment with docetaxel improves DDFS compared with vinorelbine. A brief course of trastuzumab administered concomitantly with docetaxel is safe and effective and warrants further evaluation.