gebhart/patrepeval huggingface dataset:
QuickSketch: Building 3D Representations in Unknown Environments Using Crowdsourcing (2018)

Disaster and emergency response operations require rapid situational assessment of the affected area for timely and efficient rescue operations. A 3D map, collected after a disaster, can provide such awareness, but constructing this map quickly is a significant challenge. In this paper, we explore the design of a capability called QuickSketch that rapidly builds 3D representations of an unknown environment using crowdsourcing. QuickSketch employs multiple vehicles equipped with 3D sensors (stereo cameras) to explore different areas of an unknown territory and then combines 3D data from all the vehicles to build a single 3D map. QuickSketch annotates the 3D map with important landmarks and enables rapid contextualization of visual intelligence (photos) received from first responders and disaster victims to guarantee timely backup and rescue operations. Our evaluation results show that QuickSketch can stitch a 3D map for a large campus with sub-meter mapping accuracy under certain conditions, position landmarks an order of magnitude more accurately than other image matching techniques, and contextualize visual intelligence accurately.
Control issues in rotary heart assist devices (2000)

Heart assist devices are mechanical pumps used in patients with cardiovascular diseases who are awaiting heart transplantation. With increasing clinical success, these devices are being used for longer periods of time, and automatic control has become an important requirement. The principal control requirement is to mimic the normal response of the heart to changes in demand for cardiac output, and control therefore provides many challenging problems for control engineers involved in this important multidisciplinary area of research. A team of engineers and physicians at the University of Pittsburgh is developing a hierarchical structure for a control system to support a rotary-type heart assist device. In this paper, we review various types of devices, the control algorithms used, and the problems that must be solved.
Super-resolution for a point source better thanλ/500 using positive refraction (2011)

Leonhardt demonstrated (2009) that the 2D Maxwell Fish Eye lens (MFE) can perfectly focus 2D Helmholtz waves of arbitrary frequency, i.e., it can perfectly transport an outward (monopole) 2D Helmholtz wave field, generated by a point source, towards a "perfect point drain" located at the corresponding image point. Moreover, a prototype with \lambda/5 super-resolution property for one microwave frequency has been manufactured and tested (Ma et al, 2010). However, software simulations or experimental measurements for a broad band of frequencies have not been reported. Here we present simulations with a non-perfect drain for a device equivalent to the MFE, called the Spherical Geodesic Waveguide (SGW), that predict up to \lambda/500 super-resolution close to discrete frequencies. These frequencies are directly connected with the well-known Schumann resonance frequencies of spherical symmetric systems. Out of these frequencies, the SGW does not show super-resolution in the analysis performed.
Phase I and Pharmacologic Study of PN401 and Fluorouracil in Patients With Advanced Solid Malignancies (2000)

Treatment with oral PN401 beginning 8 hours after 5-FU administration is well tolerated and results in sustained plasma uridine concentrations above therapeutic-relevant levels. The recommended 5-FU dosage for phase II evaluations is 1,250 mg/m(2)/wk for 3 weeks every 4 weeks with the intensified PN401 dose schedule (schedule 2). At this dose, systemic exposure to 5-FU as measured by AUC was five-fold higher than that observed after administration of a conventional 5-FU bolus.
Vision-based motion planning and exploration algorithms for mobile robots (1995)

This paper considers the problem of systematically exploring an unfamiliar environment in search of one or more recognizable targets. The proposed exploration algorithm is based on a novel representation of environments containing visual landmarks called the boundary place graph. This representation records the set of recognizable objects (landmarks) that are visible from the boundary of each configuration space obstacle. No metric information about the scene geometry is recorded nor are explicit prescriptions for moving between places stored. The exploration algorithm constructs the boundary place graph incrementally from sensor data. Once the robot has completely explored an environment, it can use the constructed representation to carry out further navigation tasks. In order to precisely characterize the set of environments in which this algorithm is expected to succeed, weprovide a necessary and sufficient condition under which the algorithm is guaranteed to discover all landmarks. This algorithm has been implemented on our mobile robot platform RJ, and results from these experiments are presented. Importantly, this research demonstrates that it is possible to design and implementprovably correct exploration and navigation algorithms that do not require global positioning systems or metric representations of the environment. Keywords--- exploration, navigation, mobile robots, landmarks I.
Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level (2014)

Magnetic resonance imaging (MRI) with T2-weighting is routinely performed to assess intervertebral disc degeneration. Standard clinical evaluations of MR images are qualitative, however, and do not focus on region-specific alterations in the disc. Utilizing a rabbit needle puncture model, T2 mapping was performed on injured discs to develop a quantitative description of the degenerative process following puncture. To do so, an 18G needle was inserted into four discs per rabbit (L3/L4 to L6/L7) and T2 maps were generated pre- and 4 weeks post-injury. Individual T2 maps were normalized to a disc-specific coordinate system and then averaged for pre- and post-injury population composite T2 maps. We also developed a method to automatically segment the nucleus pulposus by fitting the NP region of the T2 maps with modified 2-D and 3-D Gaussian distribution functions. Puncture injury produced alterations in MR signal intensity in a region-specific manner mirroring human degeneration. Population average T2 maps provided a quantitative representation of the injury response, and identified deviations of individual degenerate discs from the pre-injury population. We found that the response to standardized injury was modest at lower lumbar levels, likely as a result of increased disc dimensions. These tools will be valuable for the quantitative characterization of disc degeneration in future clinical and pre-clinical studies.
Performance of a 4-State Turbo Code with Data Puncturing and a BCH Outer Code (2006)

The performance of a concatenated turbo code with an outer BCH code is examined. The turbo code was based on simple 4-state constituent codes with a constrained high spread random (HSR) inter-leaver. Data puncturing, as opposed to puncturing only the parity bits, was used with the Turbo code to improve the convergence performance in the waterfall region. It is shown that this simple approach achieves performance better than the rate frac12 DVB-S2 concatenated LDPC-BCH code
Neonatal gastric intubation: Differential respiratory effects between nasogastric and orogastric tubes (1990)

The acute effects of nasogastric (NG) and orogastric (OG) tube placement on pulmonary function of neonates was assessed as a function of infant weight. Lung function was obtained on 14 healthy infants weighing less than 2 kg and 10 infants heavier than 2 kg with an NG and an OG tube in place. Additionally, 15 infants were studied for a third time without gastric intubation. Lung function was determined with an esophageal balloon and by pneumotachography (PeDS) via the least mean square analysis technique. Neither the below-2 kg infants nor the above-2 kg infants had apparent clinical compromise with NG and OG tube placement. Infants weighing less than 2 kg, however, demonstrated diminished minute ventilation and respiratory rate and had increased pulmonary resistance, resistive work of breathing, and peak transpulmonary pressure change with NG tube, as compared to OG tube, placement. The above-2 kg infants demonstrated no change in pulmonary function with NG vs. OG tube placement. These data indicate that small neonates demonstrate significant pulmonary compromise with NG placement that may not be clinically apparent.
Dinucleotide repeat polymorphism at the DXS1683 locus (1994)

Journal Article Dinucleotide repeat polymorphism at the DXS1683 locus Get access M.J. Econs, M.J. Econs * * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Francis, F. Francis 1Genome Analysis Laboratory, Impenal Cancer Research FundLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar P.S.N. Rowe, P.S.N. Rowe 2Department of Medicine, Middlesex HospitalLondon, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar M.C. Speer, M.C. Speer Search for other works by this author on: Oxford Academic PubMed Google Scholar J.L.H. O'Riordan, J.L.H. O'Riordan 2Department of Medicine, Middlesex HospitalLondon, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Lehrach, H. Lehrach 1Genome Analysis Laboratory, Impenal Cancer Research FundLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar P.A. Becker P.A. Becker Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 3, Issue 4, April 1994, Page 680, https://doi.org/10.1093/hmg/3.4.680 Published: 01 April 1994
New anthracycline antibiotics: Serirubicin and 1-hydroxyserirubicin. (1985)

New anthracycline antibiotics, serirubicin (1) and 1-hydroxyserirubicin (2) have been found in the culture filtrate of Streptomyces cyaneus MG344-hF49 (FERM BP-314), which had been previously reported to produce ditrisarubicins A, B (3) and C1). In the present paper, the production, isolation and characterization of anthracyclines 1 and 2 are reported.
Compressão de Documentos Digitalizados Baseada no Casamento de Padrões Utilizando o H.264/AVC (2009)

mtodo proposto supera objetiva
Clinical Efficacy of Carvedilol in Severe Hypertension (1991)

In an open clinical study, the efficacy and safety of carvedilol was investigated in 26 severely hypertensive patients controlled inadequately on a diuretic [diastolic blood pressure (DBP) greater than 120 mm Hg at first visit and greater than 110 mm Hg following more than 1 week administration of a diuretic]. Following diuretic treatment all patients were initially administered 5 mg of carvedilol once daily. The dose was gradually increased to 10 mg and 20 mg until DBP was reduced below 100 mm Hg or until it was reduced by at least 10 mm Hg. Antihypertensive activity of carvedilol (5 mg) was sufficient in only three cases, but after 4 weeks (inpatients) or 8 weeks (outpatients) administration of carvedilol (10 mg or 20 mg), DBP/systolic blood pressure was significantly reduced from 176 +/- 6/117 +/- 3 to 145 +/- 3/94 +/- 2 mm Hg (p less than 0.001) in all patients. Overall, a sufficient antihypertensive effect was observed in 80% of the patients. Heart rate was significantly decreased from 76 +/- 2 to 67 +/- 2 beats/min, but no patient experienced bradycardia. Carvedilol was generally well tolerated. These findings suggest that 10-20 mg of carvedilol once daily, in combination with a diuretic, is an effective and safe treatment for patients with severe hypertension.
A new era in HVDC? (2000)

The authors review the advantages of high-voltage DC transmission, and discuss the benefits that the use of voltage-sourced converters could bring. They start by giving a simple representation of an HVDC interconnection and then discuss the use and benefits of HVDC for bulk power transmission, power transmission via cables, termination between unsynchronised AC systems, parallel AC/DC transmission, and minimising short circuit capacity increases. New power semiconductor devices for HVDC are discussed, in particular, the voltage source converter and its applications in HVDC for rotating machines and reactive power control.
Preparation of Clinical‐Grade Recombinant Canarypox–Human Immunodeficiency Virus Vaccine–Loaded Human Dendritic Cells (2002)

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good manufacturing practice-grade ALVAC-HIV vaccine constructs. ALVAC infection, HIV gene expression, and DC viability and function were monitored by use of immunohistochemistry, flow cytometry, blastogenesis assays, antigen-specific interferon (IFN)-gamma enzyme-linked immunospot assay, and enzyme-linked immunosorbent assay protein detection. The vaccines infected both immature and mature DCs, and intracellular HIV-1 Gag protein was detected within hours. ALVAC-HIV induced DC maturation that was mediated by tumor necrosis factor-alpha and induced DC apoptosis that was directly related to the length of vaccine exposure. Of importance, the infected DCs remained functional in T cell stimulation assays and induced HIV antigen-specific CD8(+) T cell production of IFN-gamma from cells of HIV-1-infected individuals. These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers.
Biorthogonal modified coiflet filters for image compression (2002)

The selection of the filter bank in wavelet compression is crucial, affecting the image quality and system design. The biorthogonal coiflet (cooklet) family of wavelet filters has been constructed, and explicit frequency domain formulae have been developed in the Bernstein polynomial basis. We use the Bernstein basis for the frequency domain design and construction of biorthogonal nearly coiflet wavelet bases. In particular, we construct a previously unpublished nearly coiflet 17/11 biorthogonal wavelet filter pair. Key filter quality evaluation metrics due to Villasenor (see IEEE Trans. on Image Proc., vol.4, no.8, p.1053-1060, 1995) demonstrate this filter pair to be well suited for image compression. Comparison is made to the 17/11 biorthogonal coiflet (cooklet), Villasenor 10/18, Odegard 9/7, and classical CDF 9/7 wavelet bases. Simulation results with the SPIHT algorithm due to Said and Pearlman (see IEEE Trans. on Circ. and Systems, vol.6, no.3, p.243-250, 1996), and with our SR/sub SFQ/, confirm that the new 17/11 wavelet basis outperforms the others for still image compression.
Effect of HIV‐1 Tat on enteric neuropathogenesis (653.6) (2014)

The gastrointestinal (GI) tract is a major target and reservoir of the HIV virus. Acute and chronic HIV infection induces a higher level of CD4 T cell depletion in the GI tract compared to peripheral blood and affects motility and digestion. Since the enteric nervous system regulates these processes, it may be a potential target of HIV infection. The majority of HIV effects are not achieved by lytic propagation of the virus but by viral proteins. HIV‐1 Tat, a regulatory protein between 86 to 101 amino acids is released by infected cells and together with other HIV proteins has been shown to modulate neuronal function in the central nervous system. However little is known about its effects on the GI tract. In this study, we examined the effects of Tat on single isolated enteric neurons and in isolated ileum tissue. At the cellular level, in whole cell patch clamp experiments, Tat increased enteric neuronal excitability both in Tat treated (n=20) and in ileum neurons isolated from mice expressing the tat gene (n=9) by a significant increase in number of action potentials evoked, decrease in rheobase (from 20pA to 10pA) and threshold potential (from ‐13.2mV to ‐16.1 mV). This increase was mediated by a leftward shift of the sodium channel activation curve (‐ 10mV decrease in V0.5 of activation) thereby increasing the steady state availability of sodium channels. Tat selectively increased the mRNA and protein expression of Nav1.7 and Nav1.8 isoforms of the sodium channel. In isolated ileum tissues, Tat elicited an inflammatory response which was observed by an up regulation of pro‐inflammatory cytokines and increased GI motility thereby contributing to the HIV mediated GI dysmotilities observed in HIV patients Grant Funding Source : Supported by the National Institute of Health grants DK046367 and DA024009 and the VCU‐IMSD 541332
HARB: A Hypergraph-Based Adaptive Consortium Blockchain for Decentralized Energy Trading (2020)

The emergence of the Internet of Things (IoT) and distributed energy resources (DERs), has given rise to collaborative communities that manage their energy production and consumption load through peer-to-peer decentralized energy trading (P2P DET). To address the issue of distributed trust in these communities, blockchain technology is widely considered as a promising solution due to its ability to provide records provenance and visibility. However, the current blockchain-based platforms are known to compromise on scalability and privacy in favor of trustless interactions and often do not support interoperability. In this work, we propose a hypergraph-based adaptive consortium blockchain (HARB) framework, which coordinates DERs through high-order relationships rather than P2P pairwise relationships. HARB is presented in a three-layered network architecture to address the aforementioned challenges. The bottom layer (Underlay) addresses the issue of scalability, by exploiting the rich representation ability of hypergraphs to describe complex relationships among DERs and end users. We use the described complex relations to form scalable network clusters with intra- and inter-community energy trading relationships. The middle layer (Overlay) presents a blockchain service model to describe adaptive blockchain modules that support interoperability between the network clusters. To preserve privacy, we present a data tagging and anonymization model in the top layer (Contract), which attributes transactions to specific network clusters. To evaluate our framework, we modeled various IoT devices with different computing resource profiles to simulate a distributed energy trading (DET) environment. The analyzed results have shown that our proposed framework can effectively improve the performance of blockchain-based DET systems.
Future Requirements of Modeling Software for Integrated Optical Communication Systems (2012)

As silicon photonics processes mature and become available to an ever growing user base, the infrastructure needed to support large scale design needs to follow suit. We discuss here future requirements for modeling of integrated optical communication systems.
HALOGENATED TRIAZINEDIONES BEHAVE AS ANTAGONISTS OF PKR1: IN-VITRO AND IN-VIVO PHARMACOLOGICAL CHARACTERIZATION (2014)

Different prokineticin receptor antagonists, based on the triazinedione scaffold, were synthesized by a new efficient method. Here we demonstrated that 5-benzyl triazinediones substituted in position para of the benzyl group with halogens provide compounds endowed with interesting selectivity for the Prokineticin receptor 1 (PKR 1 ). BRET technology indicates that such substitution results in increased affinity for the PKR 1 .The affinity for PKR 2 , always in M range, was never significantly affected by the parahalogen-benzyl pharmacophores. The analog bearing a para-bromobenzyl pharmacophore (PC-25) displayed the highest affinity for PKR 1 (~18 times higher than the reference PC-1 that bears a para-ethyl benzyl group) and the highest selectivity (~300 times). The other halogen substituted analogs (PC-7, PC-18 and PC-35), showed selectivity for PKR 1 more than 100 times higher than for PKR 2 . Using transgenic mice lacking one of the two PKRs we demonstrated that all these compounds were able to abolish the Bv8-induced hyperalgesia in mice still expressing the PKR 1 at doses lower than those necessary to abolish hyperalgesia in mice expressing only the PKR 2 . The dose ratio reflected the invitro evaluated receptor selectivity.
Correction: Induction of cyclooxygenase‐2 expression by allergens in lymphocytes from allergic patients conversion via the transcription factor E2A (2006)

Due to an error, the name of Francisco Sobrino (Departamento de Bioquímica Médica y Biología Molecular, Universidad de Sevilla, Sevilla, Spain) was unfortunately omitted from the list of authors. The correct list of authors is as given above.
Mantra project - Part A: Design, implementation and test of a multi-model systolic neural network accelerator (1994)

. A multi-model neural network computer has been designed and realized. A compute intensive application using the Kohonen self-organizing map, in the field of power system monitoring, has been ported onto the neural machine. The system is described and its performance is evaluated and discussed. 1. INTRODUCTION This paper overviews the first phase of the MANTRA project, now reaching the final stage. A digital neuro-computer has been developed to fulfill the computational requirements of demanding neural network applications. The hardware has been designed to support several popular neural network algorithms. Section 2 describes the basic principles of the systolic processing element used in the computations and of the machine that has been built around that chip. A few other artificial neural systems exist today and display features not too dissimilar from those of the neuro-computer presented here. Each implies specific modifications to the algorithms to suit the implemented hardware...