gebhart/patrepeval huggingface dataset:
Continuous precipitation polymerization of acrylic acid in supercritical carbon dioxide: The polymerization rate and the polymer molecular weight (2005)

Abstract The precipitation polymerization of acrylic acid in supercritical carbon dioxide was studied in a continuous stirred tank reactor with 2,2′‐azobis(2,4‐dimethylvaleronitrile) as the free‐radical initiator. The reactor temperature was between 50 and 90 °C, the pressure was 207 bar, and the average residence time was between 12 and 40 min. The product polymer was a white, dry, fine powder that dissolved in water. A wide range of polymer molecular weights (5–200 kg/mol) was obtained. The effects of the operating variables on the polymerization rate and on the polymer molecular weight were evaluated. The observed kinetics suggested that polymerization took place in both the supercritical fluid and the precipitated polymer particles. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 2546–2555, 2005
Neuroscience via computer (2007)

article Share on Neuroscience via computer: brain exercise for older adults Author: Michael Merzenich Posit Science, [email protected] Posit Science, [email protected]View Profile Authors Info & Claims InteractionsVolume 14Issue 4July + August 2007 pp 42–45https://doi.org/10.1145/1273961.1273984Online:01 July 2007Publication History 4citation980DownloadsMetricsTotal Citations4Total Downloads980Last 12 Months125Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia (2022)

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by deficiency of the mitochondrial protein frataxin. Lack of frataxin causes neuronal loss in various areas of the CNS and PNS. In particular, cerebellar neuropathology in FRDA patients includes loss of large principal neurons and synaptic terminals in the dentate nucleus (DN), and previous studies have demonstrated early synaptic deficits in the Knockin-Knockout mouse model of FRDA. However, the exact correlation of frataxin deficiency with cerebellar neuropathology remains unclear. Here we report that doxycycline-induced frataxin knockdown in a mouse model of FRDA (FRDAkd) leads to synaptic cerebellar degeneration that can be partially reversed by AAV8-mediated frataxin restoration. Loss of cerebellar Purkinje neurons and large DN principal neurons are observed in the FRDAkd mouse cerebellum. Levels of the climbing fiber-specific glutamatergic synaptic marker VGLUT2 decline starting at 4 weeks after dox induction, whereas levels of the parallel fiber-specific synaptic marker VGLUT1 are reduced by 18-weeks. These findings suggest initial selective degeneration of climbing fiber synapses followed by loss of parallel fiber synapses. The GABAergic synaptic marker GAD65 progressively declined during dox induction in FRDAkd mice, while GAD67 levels remained unaltered, suggesting specific roles for frataxin in maintaining cerebellar synaptic integrity and function during adulthood. Expression of frataxin following AAV8-mediated gene transfer partially restored VGLUT1/2 levels. Taken together, our findings show that frataxin knockdown leads to cerebellar degeneration in the FRDAkd mouse model, suggesting that frataxin helps maintain cerebellar structure and function.
Abstract 5617: A novel genetically modified oncolytic vaccinia virus selectively replicates in tumors to activate an inflammatory TME and induce tumor regression (2022)

Abstract Oncolytic viruses (OVs) have been widely investigated as cancer immunotherapy platforms and are represented by a diverse group of DNA and RNA viruses. We are currently investigating a genetically modified oncolytic vaccinia virus as a best-in-class tumor-selective investigational product for the treatment of solid tumors. Specifically, the viral thymidine kinase (TK) has been deleted to enhance safety by greatly limiting replication in healthy tissues while taking advantage of relatively higher endogenous TK levels in tumors. In addition to tumor-selective replication, the oncolytic vaccinia virus encodes an IL-2 variant (IL-2v) protein, which diminishes preferential activation of immunosuppressive Treg cells while preserving activation of CD8+ and NK cells and avoiding toxicities associated with wild type IL-2. Using a murine surrogate of the oncolytic vaccinia virus, we assessed preclinical efficacy in multiple murine syngeneic tumor models demonstrating selective tumor localized replication resulting in tumor growth inhibition. Consistent with tumor selective virus replication, viral copy number and IL-2v transgene levels were increased and had prolonged expression in the tumors compared to the periphery. Intratumoral colocalization of the virus and IL-2v was confirmed by IHC and ISH, respectively. Tumor growth inhibition was associated with increases in tumor infiltrating CD8 and NK effector cells. Additionally, efficacy of the mouse surrogate virus was associated with systemic increases in circulating total CD8 and NK cells as well as pSTAT5+ CD8 and NK cells in the blood. In summary, we have demonstrated that arming a TK-deficient oncolytic vaccinia virus with an IL-2v transgene can effectively couple short-term destruction of tumor cells through oncolysis with the activation of anti-tumor immune response in the tumor microenvironment. These data support the study of this therapy in Phase 1 clinical trials. Citation Format: Anne-Laure Goenaga, I-Ming Wang, Bryan S. Clay, Susanne Lang, Annabel Wang, Peter Weady, Smitha P.S. Pillai, Sripad Ram, Leah Mitchell, Michael Eisenbraun, Joseph Binder, Liliana Maruri Avidal, David Kirn, Robert Hollingsworth, Clare Lees. A novel genetically modified oncolytic vaccinia virus selectively replicates in tumors to activate an inflammatory TME and induce tumor regression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5617.
Inferring the Demographics of Search Users (2013)

Knowing users’ views and demographic traits oers a great potential for personalizing web search results or related services such as query suggestion and query completion. Such signals however are often only available for a small fraction of search users, namely those who log in with their social network account and allow its use for personalization of search results. In this paper, we oer a solution to this problem by showing how user demographic traits such as age and gender, and even political and religious views can be eciently and accurately inferred based on their search query histories. This is accomplished in two steps; we rst train predictive models based on the publically available myPersonality dataset containing users’ Facebook Likes and their demographic information. We then match Facebook Likes with search queries using Open Directory Project categories. Finally, we apply the model trained on Facebook Likes to large-scale query logs of a commercial search engine while explicitly taking into account the dierence between the traits distribution in both datasets. We nd that the accuracy of classifying age and gender, expressed by the area under the ROC curve (AUC), are 77% and 84% respectively for predictions based on Facebook Likes, and only degrade to 74% and 80% when based on search queries. On a US state-by-state basis we nd a Pearson correlation of 0 :72 for political views between the predicted scores and Gallup data, and 0:54 for aliation with Judaism between predicted scores and data from the US Religious Landscape Survey. We conclude that it is indeed feasible to infer important demographic data of users from their query history based on labelled Likes data and believe that this approach could provide valuable information for personalization and monetization even in the absence of demographic data.
Lessons Learned From a Randomized Study of Oral Valganciclovir Versus Parenteral Ganciclovir Treatment of Cytomegalovirus Disease in Solid Organ Transplant Recipients: The VICTOR Trial (2016)

The VICTOR study showed comparable efficacy of treatment with intravenous ganciclovir and oral valganciclovir for cytomegalovirus (CMV) disease in solid organ transplant recipients. Oral therapy is now recommended treatment in clinical practice and guidelines. The VICTOR biobank was used in a series of post hoc analyses that yielded unique and clinically valuable insights into CMV treatment and pathogenesis. For example, the importance of tailoring therapy to initial viral load, the effect of immunosuppression on outcomes, and the need to continue therapy until undetectable viral load to prevent recurrence and emergence of resistant strains. Data were also used to validate the use of international units (IU) in quantitative measurements of CMV DNAemia, which may help future studies to define relevant cutoffs for treatment guidance. The analyses also showed the importance of inflammation on viral outcomes and identified potential targets for future studies. Here we summarize the valuable lessons learned from analysis of the VICTOR data set and sample repository.
Development of a Stereoselective Cobalt‐Mediated Dihydropyran Ring Contraction. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ecofriendly Synthesis of Silver Nanoparticles Using Aqueous Extracts of Zingiber officinale (Ginger) and Nigella sativa L. Seeds (Black Cumin) and Comparison of Their Antibacterial Potential (2020)

Applications of chemical synthetic methods for the preparation of metal nanoparticles involve toxic reagents, which are hazardous to both humans and the environment. On the other hand, ecofriendly plant-based techniques offer rapid, non-toxic, and suitable alternatives to the traditional methods. Herein, we report an eco-friendly method for the preparation of silver nanoparticles (Ag NPs) using two different aqueous extracts of Zingiber officinale (ginger) and Nigella sativa L. seeds (black cumin). Successful preparation of Ag NPs was confirmed by X-ray diffraction, ultraviolet–visible (UV-Vis) spectroscopy, and energy dispersive spectroscopy (EDX). Transmission electron microscopy (TEM) analysis revealed that Nigella sativa L. seed extract (NSE) produced a smaller size of NPs (~8 nm), whereas the ginger extract (GE) led to the formation of slightly larger Ag NPs (~12 nm). In addition, to study the effect of concentration of the extract on the quality of resulting NPs, two different samples were prepared from each extract by increasing the concentrations of the extracts while using a fixed amount of precursor (AgNO3). In both cases, a high concentration of extract delivered less agglomerated and smaller-sized Ag NPs. Furthermore, the antibacterial properties of as-prepared Ag NPs were tested against different bacterial strains. Notably, despite the slightly better quality of Ag NPs obtained from NSE (NSE-Ag), NPs prepared by using GE (GE-Ag) demonstrated superior antibacterial properties. In case of the plant-extract-based synthesis of nanoparticles, it is widely reported that during the preparation, the residual phytomolecules remain on the surface of resulting NPs as stabilizing agents. Therefore, in this case, the high antibacterial properties of GE-Ag can be attributed to the contributing or synergetic effect of residual phytomolecules of GE extract on the surface of Ag NPs, since the aqueous extract of GE has been known to possess higher intrinsic bactericidal properties when compared to the aqueous NSE extract.
Role of Semen in Modulating the Female Genital Tract Microenvironment – Implications for HIV Transmission (2014)

Semen deposition results in modulated immunity and an inflammatory response of the genital mucosa, which promotes conditions facilitating conception and pregnancy. These semen-induced alterations in the female reproductive tract can also have implications for the sexual transmission of viral infections such as HIV-1. Semen is not only a vector for HIV-1 but also a carrier for pro- and antiviral factors. Semen induces significant mucosal changes upregulating gene, and transcription factors leading to recruitment and activation of HIV target cells, stimulation of HIV replication and potentiation of Toll-like receptor responses. Although more research is needed to clearly elucidate the resulting collective effects of all these factors, semen modulation of the cervicovaginal microenvironment and immune system appears to lead, through multiple mechanisms, to mucosal changes facilitating viral entry and replication, likely resulting in enhanced susceptibility to acquire HIV-1 infection.
The influence of fixation of biological samples on cell count and marker expression stability in flow cytometric analyses (2020)

The most common applications of flow cytometry (FC) include diagnostics of haemato-oncological disorders, based on analysis of bone marrow, peripheral blood (PB), or cerebrospinal fluid (CSF) samples. A proper diagnostic process requires standardisation in setting the optimal time frame between material collection and the assay. Unfortunately, this might be difficult to achieve in daily practice due to unintended shipment delays, which might compromise large-scale multicentre studies. Thus, material fixation should be considered as a solution. The most widely used fixative agents are: paraformaldehyde, TransFix<sup>®</sup>, Cyto-Chex<sup>®</sup>, and serum-containing media. In this review, we attempted to summarise the literature data on the influence of sample storage under different temperatures and times combined with different fixation conditions on the cell count and marker expression levels. Based on the findings of several extensive studies employing fixed PB samples, it can be concluded that the performance of particular fixative greatly depends on the analysed marker and specific PB cell population expressing a given antigen. Preservation of absolute cell count was usually better in Cyto-Chex<sup>®</sup>-fixed PB samples, whereas TransFix<sup>®</sup> tended to better stabilise marker expression levels. CSF-based studies reveal that both serum-containing media and TransFix<sup>®</sup> can prevent cellular loss and enhance FC-based detection of leptomeningeal localisations of haematological malignancies, the latter being more available and having longer shelf-life. As both cell count and marker expression level are the main determinants of quality of biological samples dedicated to FC analyses, it remains to be addressed by the investigators which is the fixative of choice for their specific research aims.
Stability of Adaptive Delta Modulators with a Forgetting Factor and Constant Inputs (2006)

Motivated by applications to feedback control over communication networks where the actuation and feedback signals are transmitted over communication channels, we study the stability of Adaptive Delta Modulators (ADM) when the coded signal is a constant. The importance of such a setting arises because a common control task is to track a dc input. In an earlier paper we had shown that a standard accumulator based adaptive delta modulator has the following characteristic: that virtually all combinations of the algorithm parameters result in 4-cycles, that the avoidance of 4-cycles requires a nongeneric initialization, and that steady state oscillations that generically arise in the course of these cycles can have amplitudes that can be arbitrarily close to the initial error. Consequently, in this paper we study the use of a forgetting factor in the ADM loop, and provide a detailed stability analysis and design guidelines.
Genome Structures and Halophyte-Specific Gene Expression of the Extremophile Thellungiella parvula in Comparison with Thellungiella salsuginea ( Thellungiella halophila ) and Arabidopsis (2010)

The genome of Thellungiella parvula, a halophytic relative of Arabidopsis (Arabidopsis thaliana), is being assembled using Roche-454 sequencing. Analyses of a 10-Mb scaffold revealed synteny with Arabidopsis, with recombination and inversion and an uneven distribution of repeat sequences. T. parvula genome structure and DNA sequences were compared with orthologous regions from Arabidopsis and publicly available bacterial artificial chromosome sequences from Thellungiella salsuginea (previously Thellungiella halophila). The three-way comparison of sequences, from one abiotic stress-sensitive species and two tolerant species, revealed extensive sequence conservation and microcolinearity, but grouping Thellungiella species separately from Arabidopsis. However, the T. parvula segments are distinguished from their T. salsuginea counterparts by a pronounced paucity of repeat sequences, resulting in a 30% shorter DNA segment with essentially the same gene content in T. parvula. Among the genes is SALT OVERLY SENSITIVE1 (SOS1), a sodium/proton antiporter, which represents an essential component of plant salinity stress tolerance. Although the SOS1 coding region is highly conserved among all three species, the promoter regions show conservation only between the two Thellungiella species. Comparative transcript analyses revealed higher levels of basal as well as salt-induced SOS1 expression in both Thellungiella species as compared with Arabidopsis. The Thellungiella species and other halophytes share conserved pyrimidine-rich 5' untranslated region proximal regions of SOS1 that are missing in Arabidopsis. Completion of the genome structure of T. parvula is expected to highlight distinctive genetic elements underlying the extremophile lifestyle of this species.
Plain medicine tablet identification using geometric invariant image matching (2019)

The growing availability of counterfeit drugs has greatly increased the need for track and trace of drugs through the supply chain. Although numerous methods such as tagging, labelling, and marking are available for identifying and authenticating drug packages, none are available for the contents. A method is presented for directly identifying individual medicine tablets without any markings or additives. A lighting system is used to capture an image of a tablet’s micro-scale surface bumps, which is then used as the "fingerprint" of that tablet. Since plain unmarked tablets have no macroscopic (humanvisible) feature, the orientation of the fingerprint image cannot be controlled during capture. Tablets are thus identified by geometric invariant image matching using Fourier-Mellin phase features. Experimental results show that the proposed image matching algorithm enables accurate and robust identification of numerous plain tablets.
An Emerging Class of Volatile Organic Compound Sorbents:  Friedel−Crafts Modified Polystyrenes. 2. Performance Comparison with Commercially-Available Sorbents and Isotherm Analysis (1996)

The performance of Friedel−Crafts modified polystyrene (FCMPS) as a volatile organic compound (VOC) sorbent is compared with commercially available polymers and activated carbon. Detailed analyses of the equilibrium isotherms are presented, including vapor phase isotherm temperature dependence and isosteric heats of sorption. Although significant absorption contributions are observed for the polymeric sorbents of this study, the data are mathematically well represented by Polanyi potential analysis. FCMPS can be synthesized with desirable performance qualities such as ultimate VOC sorption capacity of ∼2 mL/g, competitively high capacity in dilute streams versus activated carbon, insensitivity to humidity in vapor phase applications, and comparative ease of regeneration.
Angiogenesis drives psoriasis pathogenesis (2009)

Psoriasis pathogenesis is closely associated with disease-inducing Th1 and Th17 cells. Yet, several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly contributes to disease manifestation. Histological hallmarks of psoriatic skin include the infiltration of multiple immune cells, keratinocyte proliferation and increased dermal vascularity. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators like vascular endothelial growth factor, hypoxia-inducible factors, angiopoietins and pro-angiogenic cytokines, such as tumour necrosis factor (TNF), interleukin (IL)-8 and IL-17, are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. Interestingly, many therapies target not only immune cells, but also protein structures of endothelial cells. Here we summarize the role of pro-angiogenic factors in psoriasis development and discuss angiogenesis as a potential target of novel therapies.
Nonlinear Model Predictive Control for power-split Hybrid Electric Vehicles (2010)

In this paper, a causal optimal controller based on Nonlinear Model Predictive Control (NMPC) is developed for a power-split Hybrid Electric Vehicle (HEV). The global fuel minimization problem is converted to a finite horizon optimal control problem with an approximated cost-to-go, using the relationship between the Hamilton-Jacobi-Bellman (HJB) equation and the Pontryagin's minimum principle. A nonlinear MPC framework is employed to solve the problem online. Different methods for tuning the approximated minimum cost-to-go as a design parameter of the MPC are discussed. Simulation results on a validated high-fidelity closed-loop model of a power-split HEV over multiple driving cycles show that with the proposed strategy, the fuel economies are improved noticeably with respect to those of an available controller in the commercial Powertrain System Analysis Toolkit (PSAT) software and a linear time-varying MPC controller previously developed by the authors.