gebhart/patrepeval huggingface dataset:
Recent advances in the molecular genetics of hypertension (1996)

The application of genetic strategies to studies of the pathogenesis of hypertension has proceeded on multiple fronts in the past year and has provided new insight into disease pathogenesis. Studies of monogenic forms of hypertension have led to the identification of genes causing Liddle's syndrome and the syndrome of apparent mineralocorticoid excess, while studies of essential hypertension have examined the potential roles of a number of candidate genes. Animal models have been exploited, both by mapping of naturally occurring mutations that alter blood pressure and by physiologic analysis of animals harboring specific engineered mutations.
Effect of micro-magnesium oxide admixture on rheological and compressive strength properties of class G well cement (2022)

Rheological property tuning is one key aspect of oil-well cement, not only affecting the cement slurry placement but also indirectly impacting other cementing properties such as the bonding strength and compressive strength. However, the research is scant on the rheological properties of blending magnesium oxide with class G oil-well cement, despite some studies having been conducted on its impacts on shrinkage compensation, compressive strength, bonding strength, and permeability properties of oil-well cement. This work studies the effects of micro-sized magnesium oxide on the rheological properties and compressive strength of the formulated API Class G oil-well cement slurries. Two types of micro-sized magnesium oxide (50 μm and 100 μm) were used as the mineral admixture at different dosages (3%, 9%). The base formulated slurry sample was incorporated with the silica flour and several commercialized additives such as retarder, fluid loss control agent, and defoamer. A batch of flow tests have been conducted by the use of a digital viscometer at two different temperatures, 25 and 88°C. The compressive strength has also been measured after curing the samples with the same formulation and conditions for 7 days. The variations of the rheological properties (plastic viscosity, yield stress, and gel strength), shear stress–shear rate correlations, and shear-thinning/thickening behavior are impacted by the temperature, the type, and dosage of magnesium oxide. The plastic viscosity of the tested slurries decreased by 27.0% (type II, 9%, 25°C) and 15.1% (type II, 3%, 88°C), respectively, and the yield stress increased by 258.5% (type II, 3%, 88°C) and 53.9% (type II, 9%, 25°C). The gel strength generally increases as the magnesium oxide dosage increases. However, all tested slurry samples show shear-thinning behavior and non-Newtonian characteristics. Among the tested slurry samples, it is found that better rheological performance is achieved when incorporating magnesium oxide with a smaller particle size. On the other side, the specimens of mixed magnesium oxide with a bigger particle size and medium dosage outperform their rival with a smaller particle size in compressive strength.
Pilot-based product superposition for downlink multiuser MIMO (2013)

In the fading MIMO broadcast channel, until recently the results under full CSIR and no CSIR indicated that degrees of freedom (DoF) cannot be improved beyond what is available via TDMA. Recently, however, it was discovered that when one node has full CSIR and the other has none, TDMA is no longer DoF-optimal and a product decomposition with noncoherent (Grassmannian) signaling achieves the optimal DoF under certain receiver antenna configurations. This work extends product superposition to the domain of coherent signaling with pilots, showing that it can also achieve the optimal DoF. In addition, this work demonstrates the advantages of product superposition in low-SNR as well as high-SNR, and extends the set of receiver antenna configurations under which product decomposition achieves optimal DoF.
Letter to the editor (1984)

Pain: October 1984 - Volume 20 - Issue 2 - p 209 doi: 10.1016/0304-3959(84)90103-9
Multiwalled Carbon Nanotube Crossbar Junction Formation via Microcontact Printing (2008)

Here, we present an approach to design, fabricate, and create a simple, low-cost, and rapid prototyping crossbar junction using a p-type and n-type multiwalled carbon nanotubes (MWCNTs) via microcontact printing. This is achieved using poly-dimethylsiloxane (PDMS) molds. The parallel relief structure in order of a few micrometers is used to transfer continuous horizontal arrays of these MWCNTs in aqueous suspension. Using an alignment and the stamping process, PDMS molds are inked alternatively with p-type and n-type MWCNTs suspensions and transferred in a grid-like manner onto the base microelectrode platform. Parallel alignment of these MWCNTs is achieved due to the geometry of the mold relief structures. The hierarchical assembly results in the formation of the crossbar array structures. The functionality of this circuit has been demonstrated through the current–voltage (I–V) characteristics associated with the junction formation.
Human thymocytes bind to autologous and allogeneic thymic epithelial cells in vitro. (1986)

The thymus plays a critical role in the generation of immunocompetent T lymphocytes. In the thymus, lymphocytes are in close contact with epithelial cells, and this contact is necessary for T-cell maturation. Using cultured human thymic epithelial (TE) cells, we have found that human thymocytes bind to human TE cells in vitro. Thymocytes bound to both allogeneic and autologous TE cells and to the epidermoid carcinoma cell line A431 but did not bind to epidermal keratinocytes or to thymic fibroblasts. Thymocyte binding to TE cells was trypsin- and cytochalasin B-sensitive. Indirect immunofluorescence assays showed that both mature (T6-, T3+) and immature (T6+, T3-) thymocytes bound TE cells. In our system, TE-thymocyte binding was not inhibited by antibodies to class I or class II major histocompatibility antigens. In vitro binding of thymocytes to TE cells may represent a correlate of in vivo TE-thymocyte interactions and provides a model system for the study of human intrathymic T-lymphocyte maturation and activation.
Figure S1 from Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer (2023)

&lt;p&gt;PTC-028 inhibits endometrial cancer cell viability&lt;/p&gt;
Selection of Peptide Ligands for Human Placental Transcytosis Systems Using In Vitro Phage Display (2011)

Fetal pharmacotherapy generally relies on nonspecific biodistribution of therapeutic agents to the unborn child following drug administration into the maternal circulation system. Physiologically, transfer of polar, high-molecular weight solutes across the placenta is facilitated by a specialized, vesicular transport mechanism termed transcytosis. To develop biotechnology-based drugs such as proteins, DNA, and siRNA as clinically effective therapeutics, transcytosis systems have been evaluated as a promising strategy to augment drug transfer across endothelial and epithelial barriers. Screening of random peptide libraries using phage display is a powerful technology to identify peptide sequences with high affinity for surface proteins on desired target cells. Here, we describe assembly of a diverse, cyclic heptapeptide library on the icosahedral T7 bacteriophage platform. This phage-displayed library of random peptides was used for functional in vitro screens across BeWo cell monolayers to identify peptide ligands that facilitate placental transcytosis of viral particles across this cell culture model of the human trophoblast barrier.
Neural Plasticity in Amblyopia (2021)

Early in life, the brain has a substantial capacity for change, often referred to as neuroplasticity. Disrupted visual input to the brain during an early “critical” or “sensitive period” of heightened neuroplasticity induces structural and functional changes within neural systems and causes amblyopia, a sensory disorder associated with abnormal development of the brain areas involved in perception. Amblyopia impairs a broad range of visual, multisensory, and motor functions, and recovery from amblyopia requires a substantial change in visual information processing within the brain. Therefore, not only is amblyopia caused by an interaction between visual experience and heightened neuroplasticity, recovery from amblyopia also requires significant neuroplastic change within the brain. A number of evidence-based treatments are available for young children with amblyopia whose brains are still rapidly developing and have a correspondingly high level of neuroplasticity. However, adults with amblyopia are often left untreated because of the idea that the adult brain no longer has sufficient neuroplasticity to relearn how to process visual information. In the early 21st century, it became clear that this idea was not correct. A number of interventions that can enhance neuroplasticity in the mature visual cortex have been identified using animal models of amblyopia and are now being translated into human studies. Other promising techniques for enhancing visual cortex neuroplasticity have emerged from studies of adult humans with amblyopia. Examples of interventions that may improve vision in adult amblyopia include refractive correction, patching of the amblyopic eye (reverse patching), monocular and binocular perceptual learning, noninvasive brain stimulation, systemic drugs, and exercise. The next important stage of research within this field will be to conduct fully controlled randomized clinical trials to assess which, if any, of these interventions can be translated into a mainstream treatment for amblyopia in adulthood.
Fluorophore-conjugated antibodies improve surgical resection of pancreatic cancer leading to prolonged disease-free survival and overall survival in orthotopic mouse models (2012)

Metildi, Cristina Angela MD; Kaushal, Sharmeela PhD; Talamini, Mark A. MD, FACS; Luiken, George A. MD; Hoffman, Robert M. PhD; Bouvet, Michael MD, FACS Author Information
Limit Cycle Investigations of Pulse Detonation Combustor for Pulse Detonation Turbine Engine (2010)

A pulse limit-cycle unsteady combustion calculation (PLUCC) model has been established and used for parametric study and optimization of pulse detonation combustor (PDC) for pulse detonation turbine engine (PDTE) applications. This model considers a system consisting of an inlet plenum, an air valve, a main tube with fuel injection, a convergent nozzle, and an exit plenum. A one-step chemical reaction along with variable properties for C2H4/air is implemented in the model. Pressure and heat losses are taken into account using loss coefficients. The effects of key sizing and timing parameters, including PDC length, nozzle area ratio, operation frequency, valve open time ratio, and fuel fill time ratio, were investigated systematically. A hierarchical strategy was implemented to optimize the total pressure ratio across the PDC, while satisfying the given upstream and downstream design constraints. Nomenclature f = operation frequency ff = fill fraction L = PDC length L* = PDC reference length NAR = nozzle area ratio, combustor-to-nozzle-throat area ratio inlet p = inlet pressure (supply pressure to the inlet plenum) r t p 41 = cycle average of total pressures across PDC, inlet t r t p
Characteristics of ferroelectric liquid crystal waveguide switches (1992)

The analysis, design, fabrication, and testing of ferroelectric liquid crystal (FLC) waveguides and waveguide switches are described. The TE, TM, and hybrid modes of propagation for waveguiding in the positive uniaxial FLC film are treated, including the effects of the indium tin oxide electrodes and silicon dioxide buffer layers. Grating coupling to the FLC waveguide is treated and, design for maximum diffraction efficiency is obtained. Two basic types of switch/modulator devices in single-mode waveguides are as follows: 1) cutoff (on-off) attenuation modulator and 2) deflection modulator. In both cases the modulation is produced by electrically switching the optic axis of the FLC by 45°. In the on-off modulator, this causes the propagating mode to be cut off and thus strongly attenuated. In the deflection modulator, this causes a change in the mode index, and thus the output coupled light is deflected through the grating to a new angle. The effects of attenuation in the FLC are included in this work.
O IMPACTO PSICOLÓGICO DO DIAGNÓSTICO POSITIVO DO TESTE DO PEZINHO NA RELAÇÃO MÃE–BEBÊ (2005)

Este artigo apresenta os resultados obtidos em uma pesquisa investigativa com 15 mães cujos filhos submeteram-se a um rastreamento para confirmação de fibrose cística. Dessa amostra, apenas 1 caso confirmou o diagnóstico, porém, evidenciou-se que mesmo a suspeita da doença já produz interferências no estabelecimento do laço entre mãe e bebê.
Modelling of the swelling behaviour of a fire retarded material under a cone calorimeter (2023)

Modelling the swelling behaviour of intumescent materials is an important and challenging issue because this phenomenon influences their pyrolysis process. It must be therefore considered to improve the predictability of pyrolysis models. The objective of this work was to implement a swelling model in the pyrolysis code Gpyro in order to predict the behaviour of a sample of ethylene vinyl acetate containing aluminium trihydroxide (EVA/ATH) polymer studied by cone calorimetry. This polymer is used for making the external sheath of electrical cables. Unlike existing works in the literature, the model implemented here, and adapted to EVA/ATH, does not require information on the densities of the initial and final materials, which makes it more predictive. To characterize the swelling, experiments were carried out to measure the evolution of the sample thickness as a function of time. The mass loss and the back surface temperature of the sample were also measured. This was done under different operating conditions. These measurements are compared with the swelling predicted by the model and the results were found to be in good agreement. The model can be extended easily to other materials.
Joint Pilot Sequence Design and Power Control for Max-Min Fairness in Uplink Massive MIMO (2017)

This paper optimizes the pilot assignment and pilot transmit powers to mitigate pilot contamination in Massive MIMO (multiple-input multiple-output) systems. While prior works have treated pilot assignment as a combinatorial problem, we achieve a more tractable problem formulation by directly optimizing the pilot sequences. To this end, we compute a lower bound on the uplink (UL) spectral efficiency (SE), for Rayleigh fading channels with maximum ratio (MR) detection and arbitrary pilot sequences. We optimize the max-min SE with respect to the pilot sequences and pilot powers, under power budget constraints. This becomes an NP-hard signomial problem, but we propose an efficient algorithm to obtain a local optimum with polynomial complexity. Numerical results manifest the near optimality of the proposed algorithm and show significant gains over existing suboptimal algorithms.
Vortex Nucleation Phase in Spin Torque Oscillators Based on Nanocontacts (2011)

We study the starting up phase of a current-controlled oscillator based on a magnetic vortex orbiting around a nanocontact in a spin-valve. From the idle state, current pulses down to a few nanoseconds can create the vortex, which is detected through the electrical signature of its steady-state gyration. Two ns are needed to reach the in-current equilibrium. The process can then be described by an Arrhenius law, with an activation energy that is consistent with the Oersted-field-induced separation of a vortex-antivortex pair. Requirements for deterministic nucleation are deduced, with prospects for instant-on oscillator capability.
Safety and feasibility of rhenium-186 nanoliposome (186RNL) in recurrent glioma: The ReSPECT phase 1 trial. (2021)

2061 Background: While external beam radiation therapy (EBRT) remains a central component of the management of primary brain tumors, it is limited by tolerance of the surrounding normal brain tissue. Rhenium-186 NanoLiposome ( 186 RNL) permits the delivery of beta-emitting radiation of high specific activity with excellent retention in the tumor. We report the results of the phase 1 study in recurrent glioma. Methods: A Phase 1 dose-escalation study of 186 RNL in recurrent glioma utilizing a standard 3+3 design was undertaken to determine the maximum tolerated dose of 186 RNL. 186 RNL is administered by convection enhanced delivery (CED). Infusion is followed under whole body planar imaging and SPECT/CT. Repeat SPECT/CT imaging is performed immediately following, and at 1, 3, 5, and 8 days after 186 RNL infusion to obtain dosimetry and distribution. Subjects were followed until disease progression by RANO criteria. Results: Eighteen subjects were treated across 6 cohorts. The mean tumor volume was 9.4 mL (range 1.1 – 23.4). The infused dose ranged from 1.0 mCi to 22.3 mCi and the volume of infusate ranged from 0.66 mL to 8.80 mL. From 1 – 4 CED catheters were used. The maximum catheter flow rate was 15 µl/min. The mean absorbed dose to the tumor volume was 239 Gy (CI 141 – 337; range 9 - 593), to normal brain was 0.72 Gy (CI 0.34 – 1.09; range 0.005 – 2.73), and to total body was 0.07 Gy (CI 0.04 – 0.10; range 0.001 – 0.23). The mean absorbed dose to the tumor volume when the percent tumor volume in the treatment volume was 75% or greater (n = 10) was 392 Gy (CI 306 – 478; range 143 – 593). Scalp discomfort and tenderness related to the surgical procedure did occur in 3 subjects. The therapy has been well tolerated, no dose-limiting toxicity has been observed, and no treatment-related serious adverse events have occurred despite markedly higher absorbed doses typically delivered by EBRT in patients with prior treatment. Responses have been observed supporting the clinical activity. Final results from the dose escalation will be presented. Conclusions: 186 RNL administered by CED to patients with recurrent glioma results in a much higher absorbed dose of radiation to the tumor compared to EBRT without significant toxicity. The recommended Phase 2 dose is 22.3 mCi in 8.8 mL of infusate. Clinical trial information: NCT01906385. [Table: see text]
Autocorrelation model-based identification method for ARMA systems in noise (2005)

A novel method for parameter estimation of minimum-phase autoregressive moving average (ARMA) systems in noise is presented. The ARMA parameters are estimated using a damped sinusoidal model representation of the autocorrelation function of the noise-free ARMA signal. The AR parameters are obtained directly from the estimates of the damped sinusoidal model parameters with guaranteed stability. The MA parameters are estimated using a correlation matching technique. The simulation results show that the proposed method can estimate the ARMA parameters with better accuracy as compared to other reported methods, in particular for low SNRs.
TRIM: TR independent multislice imaging (2004)

This article introduces a novel concept to overcome the dependence of image contrast on spatial positioning parameters such as the number of slices and slice separation in multislice measurements: TR-independent multislice (TRIM) acquisition allows the number of slices in a single measurement to remain independent of the repetition time TR. Ramped TRIM (rTRIM) allows the distance between the sections excited in each repetition to remain independent of the distance between the reconstructed slices. Even images from overlapping slices can be acquired without crosstalk between the images of adjacent slices due to spatially overlapping excitation profiles. This concept is based on a special reordering scheme: Within a single TR acquisition, steps are only taken from a fraction of all slices. This necessitates attribution of different phase-encoding steps to different slices within each repetition cycle. The reordering scheme can be derived by the use of a design matrix. The imaging properties of the technique are discussed theoretically and illustrated by a point spread function analysis based on simulations and phantom measurements. Potential sources of artifacts are identified and methods for their prevention are developed. Optimized implementations with different T(1)-weighted sequences such as spin echo (SE), turbo spin echo (TSE), and spoiled gradient echo acquisitions are shown on normal volunteers with imaging parameters used in routine diagnosis.
Metal-Semiconductor-Metal Directly Illuminated Electron Detector and Secondary Electron Detector with Metal Nano-Rod Array and Trench Structure to Enhance the Performance (2012)

In this work, we first fabricated the conventional metal-semiconductor-metal (MSM) interdigitated electron detector with aluminum contact as the control group, then used e-beam lithography system and reactive ion etcher (RIE) to fabricate aluminum nano-rod array structure on the contact area and used RIE to fabricate the periodic rectangle trench in the active area of the electron detector as another MSM interdigitated electron detector at the same time as the experimental group. According to the experimental data, we found that the MSM electron detectors with aluminum nano-rod array and periodic trench structure had better electricity characteristic and performance as directly illuminated and secondary electron detector.
Single-cycle, pulse-shaped critical path monitor in the POWER7+ microprocessor (2013)

A 32nm SOI critical path monitor (CPM) that can provide timing measurements to a Digital PLL for dynamic frequency adjustments in the 8-core POWER7+™ microprocessor is described. The CPM calibrates to within 2% of cycle time from nominal to turbo voltages. Its voltage sensitivity is 10mV/bit. It tracks processor temperature sensitivity to within 1.5% of nominal frequency, and has a sample jitter less than 1.5% of nominal frequency. The ability to detect noise dynamically allows the system to operate the processor closer to its optimal frequency for any given voltage, resulting in lower voltage for power savings or higher frequency for performance improvements.
Design and measurements of low power 32-kHz oscillators and a test interface in 180-nm CMOS technology (2020)

This paper presents the design and measurements of two oscillators used as oscillator cores in the 1-Hz oscillator circuit. The output frequency drift is obtained by parametric analyses varying the supply voltage from 1.1 to 1.3 V, referent current from 70 to 140 nA, bias current from 35 to 70 nA and temperature from -40°C to 80°C. The oscillator chip is processed and measured. The frequency characteristics are extracted from measurements using the test interface. The built-in test interface is supplied by an external power supply whose nominal voltage is 1.8 V. The voltage buffer within the test interface allows for indirect measurement of signals on high impedance nodes. The voltage buffer output is capable of driving standard digital multimeter (DMM) input loads.