gebhart/patrepeval huggingface dataset:
Colibration: A Collaborative Approach to In-Place Sensor Calibration (2003)

Numerous factors contribute to errors in sensor measure- ments. In order to be useful, any sensor device must be calibrated to adjust its accuracy against the expected measurement scale. In large- scale sensor networks, calibration will be an exceptionally dicult task since sensor nodes are often not easily accessible and manual device-by- device calibration is intractable. In this paper, we present a two-phase post-deployment calibration technique for large-scale, dense sensor de- ployments. In its ï¿½rst phase, the algorithm derives relative calibration relationships between pairs of co-located sensors, while in the second phase, it maximizes the consistency of the pair-wise calibration func- tions among groups of sensor nodes. The key idea in the ï¿½rst phase is to use temporal correlation of signals received at neighboring sensors when the signals are highly correlated (i.e. sensors are observing the same phenomenon) to derive the function relating their bias in amplitude. We formulate the second phase as an optimization problem and present an algorithm suitable for localized implementation. We evaluate the perfor- mance of the ï¿½rst phase of the algorithm using empirical and simulated data.
On the helix sense of gramicidin A single channels (1992)

In order to resolve whether gramicidin A channels are formed by right- or left-handed beta-helices, we synthesized an optically reversed (or mirror image) analogue of gramicidin A, called gramicidin A-, to test whether it forms channels that have the same handedness as channels formed by gramicidin M- (F. Heitz et al., Biophys. J. 40:87-89, 1982). In gramicidin M- the four tryptophan residues have been replaced with phenylalanine, and the circular dichroism (CD) spectrum therefore reflects almost exclusively contributions from the polypeptide backbone. The CD spectrum of gramicidin M- in dimyristoylphosphatidylcholine vesicles is consistent with a left-handed helical backbone folding motif (F. Heitz et al., Biophys. Chem. 24:149-160, 1986), and the CD spectra of gramicidins A and A- are essentially mirror images of each other. Based on hybrid channel experiments, gramicidin A- and M- channels are structurally equivalent, while gramicidin A and A- channels are nonequivalent, being of opposite helix sense. Gramicidin A- channels are therefore left-handed, and natural gramicidin A channels in phospholipid bilayers are right-handed beta 6.3-helical dimers.
Supplementary Tables 1-3 from Frequent Inactivation of <i>Cysteine Dioxygenase Type 1</i> Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines (2023)

&lt;p&gt;PDF File - 77K, Supplementary Table 1 displays baseline characteristics of normal breast donors and breast cancer patients.&lt;/p&gt;
Revolutionary active array using solid state 'models' and fiber optics (2002)

An active array radar concept and design is discussed. It uses advanced multichip module microwave and photonic technology in order to provide the basis for the next generation shared, conformal aperture and to meet the highest-priority military and commercial radar needs. A 3-D stack of AlN wafers is composed of GaAs MMIC chips that have been designed and manufactured in a flip chip configuration. Electronic and optoelectronic components on each subarray tile are put in the 3-D wafer stack to support the total subarray functions, and fiber optic links are used to manifold the transmit, the receive, and control signals to and from the subarray tile.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 1 from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene (2023)

Supplementary Figure 1 from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene
Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus. (1992)

Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination, they have widely spread in natural populations of the house mouse (10-40% in frequency) because of the meiotic drive advantage. We sequenced 14 Tcp-1 (t-complex polypeptide 1) genes from four t haplotypes, nine wild mice, and a rat as a reference. From a comparison of intron sequences of 610 base pairs, we dated the origin of t haplotypes to 2.9 +/- 0.7 million years ago, which predates the splitting of Mus musculus subspecies (approximately 1 million years ago). However, the Tcp-1 intron sequences of t haplotypes from different M. musculus subspecies from various parts of the world show no divergence, indicating the recent introgression (no earlier than 0.8 million years ago) of a single ancestral type. Nucleotide changes in coding regions are also consistent with this conclusion. Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies.
Efficient extraction of Cs and Sr into hydrocarbons using modified cobalt dicarbollide (1995)

Processing of defense-related nuclear wastes requires separation of the highly radioactive fission products cesium and strontium from both acidic and alkaline waste streams. The cobalt dicarbollide process, while known to be efficient and selective for Cs and Sr removal from acidic wastes, has received little attention in this country due to the use of toxic nitrobenzene as diluent. By preparing alkyl-functionalized cobalt dicarbollide derivatives, we have developed a system that utilizes non-hazardous, inexpensive hydrocarbons as diluents. The performance of this system in acidic and alkaline media, including distribution coefficients, selectivity over relevant cations, capacity, and chemical stability, will be discussed.
Supplementary Figure 3 from Progesterone Receptor Signaling in the Microenvironment of Endometrial Cancer Influences Its Response to Hormonal Therapy (2023)

&lt;p&gt;PDF - 183K, Measurement of proliferative index and ER � expression in PTENKO tumors treated under different hormonal conditions.&lt;/p&gt;
Inversion of microseismic data by least‐squares time reversal and waveform fitting (2008)

An inversion procedure is described wherein microseismic data recorded by a network of three component geophones are assumed to be represented as the sum of a compressional (P) and one or two shear (S) arrivals. The inversion operates in the frequency‐space domain and includes a linear inversion for source waveforms and a nonlinear inversion for model properties or source locations. The linear inversion effectively reverses time using a ray trace Green function to recover the source‐time functions. For the nonlinear inversion two waveform fitting functionals are constructed; one captures moveout and polarization information through a reconstructed data misfit, another captures information from arrival time differences through a spectral coherence functional. The two may be scaled and summed to form a joint χ2 misfit which may be combined with soft prior information in a Bayesian posterior. This is then maximized using global search techniques. Model calibration is accomplished by inverting waveform data from known locations (e.g. perforation shots) for anisotropy and optionally for model smoothness and Q. Micro‐earthquake event locations are determined by inverting waveform data given the calibrated model. Since the procedure involves fitting waveforms, time picking is not required. The beam‐forming property of the receiver array and the complete polarization vector are used to enhance the signal to noise ratio of arrivals. The presence of a P arrival is not necessary to determine a location. The algorithm implementation uses layered VTI models, includes losses due to spreading, transmission and Q and handles an arbitrary distribution of receivers (e.g. from horizontal or multiple wells or surface locations). The inversion permits automated, objective data analysis with quantified uncertainties in estimated unknowns.
Software Development PBL Focusing on Communication Using Scrum (2014)

In this paper, we improved the PBL (Project-Based Learning) environment aiming at the collaborative-software development education by industry-university cooperation. In the fiscal year 2011, the agile technique adopted as the software development process, and the small-scale project was tried. However, there were problems like the shortage of communication between members, the customers and difference of a member's technical capabilities and the burden was placed to the individual. In the fiscal year 2012/2013, in order to solve these problems, the development process "Scrum" was adopted. We analyzed the result of projects. In the result, Scrum was being able to perform problem solving in which the member's diversity was harnessed. It could carry out improved relations as the team by the positive participation in customer's projects. And, it could build the communication base by "making the place team". Therefore, we understood using Scrum for success of projects.
Dereplicating and Spatial Mapping of Secondary Metabolites from Fungal Cultures in Situ (2015)

Ambient ionization mass spectrometry techniques have recently become prevalent in natural product research due to their ability to examine secondary metabolites in situ. These techniques retain invaluable spatial and temporal details that are lost through traditional extraction processes. However, most ambient ionization techniques do not collect mutually supportive data, such as chromatographic retention times and/or UV/vis spectra, and this can limit the ability to identify certain metabolites, such as differentiating isomers. To overcome this, the droplet-liquid microjunction-surface sampling probe (droplet-LMJ-SSP) was coupled with UPLC-PDA-HRMS-MS/MS, thus providing separation, retention times, MS data, and UV/vis data used in traditional dereplication protocols. By capturing these mutually supportive data, the identity of secondary metabolites can be confidently and rapidly assigned in situ. Using the droplet-LMJ-SSP, a protocol was constructed to analyze the secondary metabolite profile of fungal cultures without any sample preparation. The results demonstrate that fungal cultures can be dereplicated from the Petri dish, thus identifying secondary metabolites, including isomers, and confirming them against reference standards. Furthermore, heat maps, similar to mass spectrometry imaging, can be used to ascertain the location and relative concentration of secondary metabolites directly on the surface and/or surroundings of a fungal culture.
Morphology and Stability of Growing Multiwall Carbon Nanotubes (1997)

We use ab initio and parametrized calculations to investigate the morphology and structural stability at the growing edge of multiwall carbon nanotubes. We find that these open-ended structures are stabilized against dome closure by strong covalent bonds connecting the exposed edges of adjacent walls. Growth at the open edge involves rearrangement of these bonds, which are mediated by carbon atoms bridging the gap and change the tip morphology significantly. Presence of a strong ``lip-lip'' interaction can explain formation of carbon nanotubes under annealing conditions.
Novel methyl transfer reactions: expanding the chemistry of radical SAM enzymes (2012)

Événement(s) lié(s) : - 37. FEBS Congress; Seville (ESP) - (2012-09-04 - 2012-09-09)
Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity (2020)

There is a vital need to develop in vitro models of the developing human brain to recapitulate the biological effects that toxic compounds have on the brain. To model perineural vascular plexus (PNVP) in vitro, which is a key stage in embryonic development, human embryonic stem cells (hESC)-derived endothelial cells (ECs), neural progenitor cells, and microglia (MG) with primary pericytes (PCs) in synthetic hydrogels in a custom-designed microfluidics device are cocultured. The formation of a vascular plexus that includes networks of ECs (CD31+, VE-cadherin+), MG (IBA1+), and PCs (PDGFRβ+), and an overlying neuronal layer that includes differentiated neuronal cells (βIII Tubulin+, GFAP+) and radial glia (Nestin+, Notch2NL+), are characterized. Increased brain-derived neurotrophic factor secretion and differential metabolite secretion by the vascular plexus and the neuronal cells over time are consistent with PNVP functionality. Multiple concentrations of developmental toxicants (teratogens, microglial disruptor, and vascular network disruptors) significantly reduce the migration of ECs and MG toward the neuronal layer, inhibit formation of the vascular network, and decrease vascular endothelial growth factor A (VEGFA) secretion. By quantifying 3D cell migration, metabolic activity, vascular network disruption, and cytotoxicity, the PNVP model may be a useful tool to make physiologically relevant predictions of developmental toxicity.
Defective Interfering Particles of Poliovirus IV. Mechanisms of Enrichment (1973)

Infection of HeLa cells by mixtures of standard poliovirus and defective, interfering (DI) poliovirus particles leads to a higher ratio of DI particles in the progeny than in the inoculum. The extent of this enrichment could be varied by various manipulations of the co-infected cells. At any time during the infection cycle, virions made within short times after addition of radioactive uridine were hyperenriched in DI particles; this transient hyperenrichment fell to the equilibrium enrichment level within 45 min after uridine addition. A shift of the temperature of infection from 37 to 31 C also led to a hyperenrichment of DI particles and pulse-labeling revealed a superimposed transient hyperenrichment. By contrast, cells continuously infected at 31 C showed a severe decrement in DI particles apparently because poliovirus DI particles behave as cold-sensitive mutants for RNA synthesis. Cycloheximide treatment early in the infection cycle also led to hyperenrichment. Study of the cycloheximide effect showed that the drug acted as if to change the input ratio of standard to DI particles. These effects on enrichment can be explained as aspects of two different phenomena: enrichment due to preferential DI RNA synthesis and enrichment due to preferential encapsidation of DI RNA. Both mechanisms probably play a role in the normal level of enrichment.
ChemInform Abstract: A Novel One‐Pot Conversion of Methyl Sulfones to Sulfonamides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Loss of FHIT function in lung cancer and preinvasive bronchial lesions. (1998)

We previously cloned and characterized the tumor suppressor gene FHIT (fragile histidine triad) at chromosome 3p14.2 and found that this gene is altered by deletions in human tumors, including lung cancer. To assess the frequency and specificity of inactivation and its relevance in a clinical setting, we have produced antibodies against the Fhit protein and studied its expression in a series of non-small cell lung cancers and normal bronchial mucosa and a spectrum of preinvasive lesions by immunohistochemistry. The data indicate that the loss of Fhit protein is the most frequent alteration in non-small cell lung cancer (73%) and precancerous lesions (93%), is significantly higher in the tumors of smokers (75%) than in those of nonsmokers (39%; P < 0.0005), and is an independent and more frequent event than p53 overexpression in tumors and precancerous lesions (73 versus 46%). The percentage of cases lacking Fhit expression was higher in the squamous type compared to adenocarcinoma (87 versus 57%; P < 0.00001), whereas other histotypes (large cell, mucoepidermal) showed an intermediate value (69%). Loss of Fhit expression in a very high percentage of primary lung carcinomas and precancerous lesions supports the notion that FHIT alterations play an important role in the growth control of bronchial cells. FHIT inactivation is particularly important in squamous cell carcinomas that are often associated with precursor dysplastic lesions. The overall high frequency and precocity of Fhit loss in lung carcinogenesis and the development of the presently described immunohistochemical approach suggest a potential use of this gene in the early detection of lung cancer and in chemopreventive studies as an intermediate biomarker.
Supplementary Table 6 from Tumor Subtype-Specific Cancer–Testis Antigens as Potential Biomarkers and Immunotherapeutic Targets for Cancers (2023)

&lt;p&gt;XLSX file - 29K, Supplemental Table S6. List of Coxph Regression P values of CT genes in eight cancer types.&lt;/p&gt;
High-$Q$ Tunable Evanescent-Mode Cavity SIW Resonators and Filters With Contactless Tuners (2019)

This paper presents a novel method to widely tune high-quality factor evanescent-mode cavity resonators and filters using contactless tuners. The proposed method resolves multiple challenges facing reliable manufacturing and operation of these filters by avoiding the attachment of the flexible tuner to the cavity and replacing it with capacitive contactless tuners. This paper discusses the design consideration and tradeoffs as well as demonstrates the performance of the proposed concept using the substrate-integrated-waveguide technology. The resonators demonstrate more than octave tuning range (TR), quality factor up to 650, and power handling exceeding 100 W. In addition, the second-order bandpass filters are demonstrated, along with the long-term measurements, showing better than 1.17% frequency error after a 15-h stability test, and less than 1.47% frequency error after a 450 cycles repeatability test over an octave TR from 1.8 to 3.6 GHz.
Methods and apparatus for transparent display using scattering nanoparticles (2023)

Transparent displays enable many useful applications, including heads-up displays for cars and aircraft as well as displays on eyeglasses and glass windows. Unfortunately, transparent displays made of organic light-emitting diodes are typically expensive and opaque. Heads-up displays often require fixed light sources and have limited viewing angles. And transparent displays that use frequency conversion are typically energy inefficient. Conversely, the present transparent displays operate by scattering visible light from resonant nanoparticles with narrowband scattering cross sections and small absorption cross sections. More specifically, projecting an image onto a transparent screen doped with nanoparticles that selectively scatter light at the image wavelength(s) yields an image on the screen visible to an observer. Because the nanoparticles scatter light at only certain wavelengths, the screen is practically transparent under ambient light. Exemplary transparent scattering displays can be simple, inexpensive, scalable to large sizes, viewable over wide angular ranges, energy efficient, and transparent simultaneously.
Validation of a new wearable device for type 3 sleep test without flowmeter (2021)

The X10X and X10Y devices are able to provide a correct grading of sleep respiratory disorders without the need of a nasal cannula for respiratory flow measurement and can be considered as a type 3 sleep test device for screening tests.
Live Demonstration: Smart tracker and gesture capturer for people with Parkinson’s diseases (2019)

Parkinson's disease is classified as a chronic movement disorder whose incidence is proportional to the age. It is a common progressive neurodegenerative condition associated with significant disability and negative impact on the quality of life. Its manifestations involve difficulty with coordinated movements such as asymmetric resting tremor, rigidity, and bradykinesia. These symptoms and their response to levodopa constitute the basis for a clinical diagnosis of Parkinson's disease (PD) [1] . A recent study of this disease in North America showed the prevalence of PD among those aged 45 years to be 572 per 100,000, with 680,000 individuals in the US aged 45 years with PD in 2010 and the estimative to rise to approximately 930,000 in 2020 and 1,238,000 in 2030 based on the US Census Bureau's populational projections [2] .
Synthesis of Functional Aromatic Multisulfonyl Chlorides and Their Masked Precursors (2001)

The synthesis of functional aromatic bis(sulfonyl chlorides) containing an acetophenone and two sulfonyl chloride groups, i.e., 3,5-bis[4-(chlorosulfonyl)phenyl]-1-acetophenone (16), 3,5-bis(chlorosulfonyl)-1-acetophenone (17), and 3,5-bis(4-(chlorosulfonyl)phenyloxy)-1-acetophenone (18) via a sequence of reactions, involving in the last step the quantitative oxidative chlorination of S-(aryl)- N,N'-diethylthiocarbamate, alkyl- or benzyl thiophenyl groups as masked nonreactive precursors to sulfonyl chlorides is described. A related sequence of reactions was used for the synthesis of the aromatic trisulfonyl chloride 1,1,1-tris(4-chlorosulfonylphenyl)ethane (24). 4-(Chlorosulfonyl)phenoxyacetic acid, 2,2-bis[[[4-(chlorosulfonyl)phenoxyacetyl]oxy]methyl]-1,3-propanediyl ester (27), 5,11,17,23-tetrakis(chlorosulfonyl)-25,26,27,28-tetrakis(ethoxycarbonylmethoxy)calix[4]arene (38), 5,11,17,23,29,35-hexakis(chlorosulfonyl)-37,38,39,40,41,42-hexakis(ethoxycarbonylmethoxy)calix[6]arene (39), 5,11,17,23,29,35,41,47-octakis(chlorosulfonyl)-49,50,51,52,53,54,55,56-octakis(ethoxycarbonylmethoxy)calix[8]arene (40), 5,11,17,23-tetrakis(tert-butyl)-25,26,27,28-tetrakis(chlorosulfonyl phenoxyacetoxy)calix[4]arene (44), 5,11,17,23,29,35-hexakis(tert-butyl)-37,38,39,40,41,42-hexakis(chlorosulfonylphenoxyacetoxy)calix[6]arene (45), and 5,11,17,23,29,35,41,47-octakis(tert-butyl)-49,40,51,52,53,54,55,56-octakis(chlorosulfonylphenoxyacetoxy)calix[8]arene (46) were synthesized by two different multistep reaction procedures, the last step of both methods consisting of the chlorosulfonation of compounds containing suitable activated aromatic positions. 2,4,6-Tris(chlorosulfonyl)aniline (47) was obtained by the chlorosulfonation of aniline. The conformation of two series of multisulfonyl chlorides i.e., 38, 39, 40 and 44, 45, 46, was investigated by (1)H NMR spectroscopy. The masked nonreactive precursor states of the functional aromatic multisulfonyl chlorides and the aromatic multisulfonyl chlorides reported here represent the main starting building blocks required in a new synthetic strategy elaborated for the preparation of dendritic and other complex organic molecules.
Antiviral Effect and Pharmacokinetic Interaction between Nevirapine and Indinavir in Persons Infected with Human Immunodeficiency Virus Type 1 (1999)

Nevirapine and indinavir have the potential of affecting the pharmacokinetics of each other. In a prospective trial, 24 human immunodeficiency virus (HIV)-infected subjects on stable nucleoside or no therapy were treated with 800 mg of indinavir every 8 h. After 7 days, 200 mg of nevirapine a day was added for 14 days and then increased to 200 mg twice a day. At day 7 (before nevirapine), there was a sevenfold difference among the subjects in indinavir area under the curve (AUC), and there was a significant correlation between indinavir AUC (r2=0.378, P=.019), minimum plasma concentration (Cmin; r2=0.359, P=.023), maximum plasma concentration (Cmax; r2=0.340, P=.028), and plasma HIV RNA decline. Nevirapine significantly reduced median indinavir Cmin (47.5%) and AUC (27.4%) and, to a lesser extent, Cmax (11%). Plasma HIV RNA values were </=20 copies/mL in 10 of 17 (58.8%) subjects at 58 weeks or last visit. These data suggest that indinavir dosing should be dependent on drug exposure and not on cotherapy with nevirapine.