gebhart/patrepeval huggingface dataset:
New Developments in Gallium Nitride and the Impact on Power Electronics (2006)

Wide bandgap III-nitride semiconductor materials possess superior material properties as compared to silicon, GaAs and other III-V compound materials. Recent achievements in gallium nitride (GaN) technology for optoelectronics have resulted in ultra-bright blue light emitting diodes and lasers, ultraviolet emitters, and solar-blind optical detectors. In the electronic area, drastic improvement of microwave device performance has been achieved, yielding record high power densities of 20-30 W/mm. Novel applications of these materials in high-power electronics for switching, energy conversion and control are just emerging. This paper provides an overview of the state-of-the-art III-nitride wide bandgap technologies and it explores power electronic applications while illustrating the enormous potential that GaN based devices have for overcoming the major challenges of power electronics in the 21st century. The paper discusses the unique material and device properties of GaN-based semiconductors that make them promising for high-power, high-temperature applications. These include high electron mobility and saturation velocity, high sheet carrier concentration at heterojunction interfaces, high breakdown voltages, and low thermal impedance (when grown over SiC or bulk AIN substrates). The chemical inertness and radiation hardness of nitrides are other key properties. As applied to power electronics, the Ill-Nitride technology allows for high-power switching with sub-microsecond and nano-second switching times. The paper will present the innovations that further improve the performance of high-power DC-DC converters, switches and other building blocks. These include novel insulated gate HFET design that significantly expands the allowable input voltage amplitude, further increases the device peak currents, and most importantly, tremendously improves the large-signal stability and reliability. Insulated gate switching devices have been shown to operate at up to 300 degC with no noticeable parameter degradation. Novel monolithic integrated circuits of high-power switches and DC-DC converters and their performance parameters will be presented. The paper also discusses the major challenges associated with modern GaN technology and work in progress to overcome them
Repair of porcine articular cartilage defect with autologous chondrocyte transplantation (2005)

Articular cartilage is known to have poor healing capacity after injury. Autologous chondral grafting remains the mainstay to treat well-defined, full-thickness, symptomatic cartilage defects. We demonstrated the utilization of gelatin microbeads to deliver autologous chondrocytes for in vivo cartilage generation. Chondrocytes were harvested from the left forelimbs of 12 Lee-Sung pigs. The cells were expanded in monolayer culture and then seeded onto gelatin microbeads or left in monolayer. Shortly before implantation, the cell-laden beads were mixed with collagen type I gel, while the cells in monolayer culture were collected and re-suspended in culture medium. Full-thickness cartilage defects were surgically created in the weight-bearing surface of the femoral condyles of both knees, covered by periosteal patches taken from proximal tibia, and sealed with a porcine fibrin glue. In total, 48 condyles were equally allotted to experimental, control, and null groups that were filled beneath the patch with chondrocyte-laden beads in gel, chondrocytes in plain medium solution, or nothing, respectively. The repair was examined 6 months post-surgery on the basis of macroscopic appearance, histological scores based on the International Cartilage Repair Society Scale, and the proportion of characteristic chondrocytes. Tensile stress-relaxation behavior was determined from uniaxial indentation tests. The experimental group scored higher than the control group in the categories of matrix nature, cell distribution pattern, and absence of mineralization, with similar surface smoothness. Both the experimental and control groups were superior to the null group in the above-mentioned categories. Viable cell populations were equal in all groups, but the proportion of characteristic chondrocytes was highest in the experimental group. Matrix stiffness was ranked as null > native cartilage > control > experimental group. Transplanted autologous chondrocytes survive and could yield hyaline-like cartilage. The application of beads and gel for transplantation helped to retain the transferred cells in situ and maintain a better chondrocyte phenotype.
Bit-Wise Iterative Decoding of Polar Codes using Stochastic Computing (2018)

Polar codes have received recent attention due to their potential to be applied in advanced wireless communication protocols such as the fifth generation mobile communication system (5G). Among the existing decoding algorithms, Belief Propagation (BP) exhibits high-throughput, low-latency and soft output with a high hardware cost. A form of approximate computing called stochastic computing provides a low-cost implementation solution for the BP algorithm. However, existing stochastic BP decoders suffer from a relatively long decoding latency resulting in low hardware efficiency. In this paper, a novel bit-wise iterative stochastic decoding architecture for the BP algorithm is proposed to improve the throughput and hardware efficiency. Multiple methods at the algorithm and architecture levels are presented to further speed up convergence and hardware efficiency.
O2-inhalation T2* BOLD and dual-VENC 4D flow MRI: hypoxic evaluation of pediatric transplanted kidneys (2023)

For pediatric patients with end-stage renal failure, kidney transplantation is the only treatment that can provide growth and long-term survival. Although rejection is the common cause of renal dysfunction, there are other causes of chronic transplant nephropathy, in which the transplanted kidney develops fibrosis. Hypoxia is considered as possible causes of this order. We used O2-inhalation T2*-BOLD and dual-VENC 4D flow MRI to assess hypoxia in pediatric transplanted kidneys. In patients with chronic transplant nephropathy, hypoxia was found in the renal medulla and small vessel&amp;rsquo;s flow was reduced. This analysis is an effective means of monitoring hypoxia in transplanted kidneys.
Hybrid Manufacturing of Conformal Cooling Channels for Tooling (2023)

Computer-aided manufacturing (CAM) techniques for hybrid manufacturing have led to new application areas in the manufacturing industry. In the tooling industry, cooling channels are used to enable specific heating and cooling cycles to improve the performance of the process. These internal cooling channels have been designed with limited manufacturing processes in mind, so, until recently, they were often straight in shape for cross-drilling operations and manufactured from a cast billet. To show a novel application of this common technology, a tool with integrated conformal cooling channels was manufactured using hybrid manufacturing (blown-powder DED and CNC machining) techniques. The computer-aided manufacturing strategy used, and the lessons learned are presented and discussed to enable future work in this industrial application space.
Accumulation of m 6 A exhibits stronger correlation with MAPT than β-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer’s disease (2023)

The study for the pathophysiology study of Alzheimer's disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular β-amyloid (Aβ) deposition, intracellular aggregation of microtubule associated protein tau (MAPT), inflammation and neurodegeneration. We now report on a double transgenic APP<sup>NL-G-F</sup> MAPT<sup>P301S</sup> mouse that at 6 months of age exhibits robust Aβ plaque accumulation, intense MAPT pathology, strong inflammation and extensive neurodegeneration. The presence of Aβ pathology potentiated the other major pathologies, including MAPT pathology, inflammation and neurodegeneration. However, MAPT pathology neither changed levels of amyloid precursor protein nor potentiated Aβ accumulation. The APP<sup>NL-G-F</sup>/MAPT<sup>P301S</sup> mouse model also showed strong accumulation of N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), which was recently shown to be elevated in the AD brain. M6A primarily accumulated in neuronal soma, but also co-localized with a subset of astrocytes and microglia. The accumulation of m6A corresponded with increases in METTL3 and decreases in ALKBH5, which are enzymes that add or remove m<sup>6</sup>A from mRNA, respectively. Thus, the APP<sup>NL-G-F</sup>/MAPT<sup>P301S</sup> mouse recapitulates many features of AD pathology beginning at 6 months of aging.
A smart mask for active defense against airborne pathogens (2021)

Face masks are a primary preventive measure against airborne pathogens. Thus, they have become one of the keys to controlling the spread of the COVID-19 virus. Common examples, including N95 masks, surgical masks, and face coverings, are passive devices that minimize the spread of suspended pathogens by inserting an aerosol-filtering barrier between the user's nasal and oral cavities and the environment. However, the filtering process does not adapt to changing pathogen levels or other environmental factors, which reduces its effectiveness in real-world scenarios. This paper addresses the limitations of passive masks by proposing ADAPT, a smart IoT-enabled "active mask". This wearable device contains a real-time closed-loop control system that senses airborne particles of different sizes near the mask by using an on-board particulate matter (PM) sensor. It then intelligently mitigates the threat by using mist spray, generated by a piezoelectric actuator, to load nearby aerosol particles such that they rapidly fall to the ground. The system is controlled by an on-board micro-controller unit that collects sensor data, analyzes it, and activates the mist generator as necessary. A custom smartphone application enables the user to remotely control the device and also receive real-time alerts related to recharging, refilling, and/or decontamination of the mask before reuse. Experimental results on a working prototype confirm that aerosol clouds rapidly fall to the ground when the mask is activated, thus significantly reducing PM counts near the user. Also, usage of the mask significantly increases local relative humidity levels.
Disappearance of partonic collectivity in sNN=3GeV Au+Au collisions at RHIC (2022)

We report on the measurements of directed flow v1 and elliptic flow v2 for hadrons (π±, K±, KS0, p, ϕ, Λ and Ξ−) from Au+Au collisions at sNN=3 GeV and v2 for (π±, K±, p and p‾) at 27 and 54.4 GeV with the STAR experiment. While at the two higher energy midcentral collisions the number-of-constituent-quark (NCQ) scaling holds, at 3 GeV the v2 at midrapidity is negative for all hadrons and the NCQ scaling is absent. In addition, the v1 slopes at midrapidity for almost all observed hadrons are found to be positive, implying dominant repulsive baryonic interactions. The features of negative v2 and positive v1 slope at 3 GeV can be reproduced with a baryonic mean-field in transport model calculations. These results imply that the medium in such collisions is likely characterized by baryonic interactions.
Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate. (1981)

By using polyethylene glycol 1540, BW5147 AKR T lymphoma cells were fused with splenocytes from A/J mice treated so as to induce suppressor T cells specific for azobenzenearsonate (ABA). Of 576 microwells originally seeded, 132 demonstrated growing cell clones, 4 of which produced an ABA-binding supernatant factor. When tested in vivo for suppression of delayed-type hypersensitivity to ABA, two of these cell lines, A4 and F12, were shown to produce suppressive supernatant factors. Fluorescence analysis of the F12 cells with appropriate antisera demonstrated this T cell hybrid to be Thy 1.2+, Lyt 1+,2-, and surface immunoglobulin negative, the surface marker phenotype of conventional ABA-specific suppressor T cells. This cloned suppressor cell line, F12, produces a culture supernatant factor that is suppressive at dilutions up to 1:100 and has provided material for genetic and immunochemical analysis.
Trefoil Factor 2 Regulates Airway Remodeling in Animal Models of Asthma (2011)

The current study demonstrates a role of TFF2 in airway remodeling in mouse models of airway disease. Further studies into the mechanisms of action of TFF2 and its role in asthma are warranted.
Supplementary Figures 1- 7 from ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells (2023)

&lt;p&gt;Figure S1A-C - Dot plots and histograms from flow cytometry analysis of SK-MEL-5-educated M-MDSCs and PBMCs cultured in medium alone.&lt;/p&gt;&lt;p&gt;Figure S1D - FACS result of cell surface staining of cytokine-induced M-MDSCs and PBMCs cultured in medium alone.&lt;/p&gt;&lt;p&gt;Figure S1E - Cell surface staining of monocytes cultured in the presence of M-CSF and IL4 and SK-MEL-5-educated M-MDSCs by staining with HLA-DR.&lt;/p&gt;&lt;p&gt;Figure S2 A-B - ILT3 is highly expressed on CD45+CD33+CD14+ myeloid cells in SK-MEL-5 tumor-infiltrating lymphocytes.&lt;/p&gt;&lt;p&gt;Figure S3 - Single-cell RNAseq (scRNAseq) of human immune cells in non-small cell lung cancer (NSCLC) public dataset.&lt;/p&gt;&lt;p&gt;Figure S4 - Association of LILRB4 expression with deconvoluted cell fractions for human tumor types in the TCGA database.&lt;/p&gt;&lt;p&gt;Figure S5 - Suppression of autologous CD8+ T cell proliferation by cytokine-induced M-MDSCs.&lt;/p&gt;&lt;p&gt;Figure S6 - CD33+ cells from PBMCs cultured in medium alone are not suppressive.&lt;/p&gt;&lt;p&gt;Figure S7 - Differentially expressed genes (DEG) between SK-MEL-5 educated M-MDSCs and monocytes.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;&lt;/p&gt;
An organic optical bistable switch (2003)

We demonstrate an organic optical bistable switch by integrating an organic photodetector on top of a transparent electrophosphorescent organic light-emitting diode. Optical bistability is achieved with an external field-effect transistor providing positive feedback. This integrated device has potential applications for automatic brightness control, image-retaining displays, and other photonic logic circuits.
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation (2007)

Differentiation of hematopoietic stem cells (HSCs) after birth is largely restricted to the bone marrow cavity, where HSCs are associated closely with osteoblasts (OBs). How OBs localize HSCs to the endosteal niche remains unclear. To explore adhesive interactions between HSCs and OBs, a cell blot analysis was used that revealed 2 major bands that corresponded to monomers and multimers of annexin II (Anxa2). Immunohistochemistry revealed that OBs and marrow endothelial cells express Anxa2 at high levels. Function-blocking studies confirmed that Anxa2 mediates HSC adhesion mainly via the N-terminal portion of the Anxa2 peptide. Adhesion of HSCs to OBs derived from Anxa2-deficient animals (Anxa2(-/-)) was significantly impaired compared with OBs obtained from wild-type animals (Anxa2(+/+)). Moreover, fewer HSCs were found in the marrow of Anxa2(-/-) versus Anxa2(+/+) animals. Short-term lodging, engraftment, and survival of irradiated mice with whole marrow cells were substantially inhibited by N-terminal peptide fragments of Anxa2 or anti-Anxa2 antibodies. Similar findings were noted in long-term competitive repopulation studies. Collectively, these findings reveal that Anxa2 regulates HSC homing and binding to the bone marrow microenvironment and suggest that Anxa2 is crucial for determining the bone marrow niche of HSCs.
Digital signal pre-processing to boost the linear power of 3G radio transmitters (2005)

In this paper, a software-reconfigurable transmitter architecture for 3G systems is presented Embedded digital signal pre-processing module is used in order to boost the linear power of the transmitter along with its power efficiency. Concurrent digital implementation of I/Q vector modulation and base-band predistortion when applied to 100 watts peak power transmitter led to a 2 dB raise of the linear output power while meeting the 3GPP standard requirements in terms of adjacent channel power ratio (ACPR) and error vector magnitude (EVM).
High-throughput dental biofilm growth analysis for multiparametric microenvironmental biochemical conditions using microfluidics (2016)

Dental biofilm formation is not only a precursor to tooth decay, but also induces more serious systematic health problems such as cardiovascular disease and diabetes. Understanding the conditions promoting colonization and subsequent biofilm development involving complex bacteria coaggregation is particularly important. In this paper, we report a high-throughput microfluidic 'artificial teeth' device offering controls of multiple microenvironmental factors (e.g. nutrients, growth factors, dissolved gases, and seeded cell populations) for quantitative characteristics of long-term dental bacteria growth and biofilm development. This 'artificial teeth' device contains multiple (up to 128) incubation chambers to perform parallel cultivation and analyses (e.g. biofilm thickness, viable-dead cell ratio, and spatial distribution of multiple bacterial species) of bacteria samples under a matrix of different combinations of microenvironmental factors, further revealing possible developmental mechanisms of dental biofilms. Specifically, we applied the 'artificial teeth' to investigate the growth of two key dental bacteria, Streptococci species and Fusobacterium nucleatum, in the biofilm under different dissolved gas conditions and sucrose concentrations. Together, this high-throughput microfluidic platform can provide extended applications for general biofilm research, including screening of the biofilm properties developing under combinations of specified growth parameters such as seeding bacteria populations, growth medium compositions, medium flow rates and dissolved gas levels.
Interobserver reliability in the endoscopic diagnosis and grading of Barrett’s esophagus: an Asian multinational study (2010)

Despite the uncommon occurrence of Barrett's esophagus in Asia, our endoscopists exhibited excellent agreement in the endoscopic diagnosis and grading of Barrett's esophagus using the Prague C & M Criteria. However, in view of the low interobserver reliability in recognizing Barrett's segments of < 1 cm, future studies in Asia should take this into account when selecting the study population.
Localization and Physical Mapping of the Prostate-Specific Membrane Antigen (PSM) Gene to Human Chromosome 11 (1995)

The prostate-specific membrane antigen (PSM) was identified by the monoclonal antibody 7E11-C5.3, which was raised against the human prostatic carcinoma cell line LNCaP (3). The PSM antigen is expressed by normal, neoplastic, and metastatic prostatic tissues. The 2.65-kb cDNA encoding the 100-kDa PSM glycoprotein was cloned from LNCaP cells (4). Studies have shown that the expression of PSM is tissue-specific (5). In the present study monochromosomal somatic cell hybrids were used to localize the PSM gene to human chromosome 11. Using this information, initial mapping studies identified two potential PSM gene loci at 11p11.1-p13 and 11q14. Further high-stringency analysis using cosmid probes identified the 11q14 region as the location of the PSM gene.
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1 (2020)

Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transcriptional co-activators YAP/TAZ. We were interested whether fibroblasts can be sensitized to TGFβ1 by activation of the GPCR/YAP/TAZ axis and whether this mechanism explains the profibrotic properties of diverse GPCR ligands. We found that LPA, S1P and thrombin cooperate in human dermal fibroblasts with TGFβ1 to induce extracellular matrix synthesis, myofibroblast marker expression and cytokine secretion. Whole genome expression profiling identified a YAP/TAZ signature behind the synergistic profibrotic effects of LPA and TGFβ1. LPA, S1P and thrombin stimulation led to activation of the Rho-YAP axis, an increase of nuclear YAP-Smad2 complexes and enhanced expression of profibrotic YAP/Smad2-target genes. More generally, dermal, cardiac and lung fibroblast responses to TGFβ1 could be enhanced by increasing YAP nuclear levels (with GPCR ligands LPA, S1P, thrombin or Rho activator) and inhibited by decreasing nuclear YAP (with Rho inhibitor, forskolin, latrunculin B or 2-deoxy-glucose). Thus, we present here a conceptually interesting finding that fibroblast responses to TGFβ1 can be predicted based on the nuclear levels of YAP and modulated by stimuli/treatments that change YAP nuclear levels. Our study contributes to better understanding of fibrosis as a complex interplay of signalling pathways and proposes YAP/TAZ as promising targets in the treatment of fibrosis.
15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis (2005)

DSG and CYC, but not MMF, prolong life, limit renal damage and prevent autoantibody formation in SCG/Kj mice.
End-to-End Learning of Geometry and Context for Deep Stereo Regression (2017)

We propose a novel deep learning architecture for regressing disparity from a rectified pair of stereo images. We leverage knowledge of the problem's geometry to form a cost volume using deep feature representations. We learn to incorporate contextual information using 3-D convolutions over this volume. Disparity values are regressed from the cost volume using a proposed differentiable soft argmin operation, which allows us to train our method end-to-end to sub-pixel accuracy without any additional post-processing or regularization. We evaluate our method on the Scene Flow and KITTI datasets and on KITTI we set a new stateof-the-art benchmark, while being significantly faster than competing approaches.
Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles (2011)

Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.
High energy bursts from a solid state laser operated in the heat capacity limited regime (1996)

High energy bursts are produced from a solid state laser operated in a heat capacity limited regime. Instead of cooling the laser, the active medium is thermally well isolated. As a result, the active medium will heat up until it reaches some maximum acceptable temperature. The waste heat is stored in the active medium itself. Therefore, the amount of energy the laser can put out during operation is proportional to its mass, the heat capacity of the active medium, and the temperature difference over which it is being operated. The high energy burst capacity of a heat capacity operated solid state laser, together with the absence of a heavy, power consuming steady state cooling system for the active medium, will make a variety of applications possible. Alternately, cooling takes place during a separate sequence when the laser is not operating. Industrial applications include new material working processes.