gebhart/patrepeval huggingface dataset:
Ultrathin Highly Luminescent Two‐Monolayer Colloidal CdSe Nanoplatelets (2019)

Abstract Surface effects in atomically flat colloidal CdSe nanoplatelets (NLPs) are significantly and increasingly important with their thickness being reduced to subnanometer level, generating strong surface related deep trap photoluminescence emission alongside the bandedge emission. Herein, colloidal synthesis of highly luminescent two‐monolayer (2ML) CdSe NPLs and a systematic investigation of carrier dynamics in these NPLs exhibiting broad photoluminescence emission covering the visible region with quantum yields reaching 90% in solution and 85% in a polymer matrix is shown. The astonishingly efficient Stokes‐shifted broadband photoluminescence (PL) emission with a lifetime of ≈100 ns and the extremely short PL lifetime of around 0.16 ns at the bandedge signify the participation of radiative midgap surface centers in the recombination process associated with the underpassivated Se sites. Also, a proof‐of‐concept hybrid LED employing 2ML CdSe NPLs is developed as color converters, which exhibits luminous efficacy reaching 300 lm W opt −1 . The intrinsic absorption of the 2ML CdSe NPLs (≈2.15 × 10 6 cm −1 ) reported in this study is significantly larger than that of CdSe quantum dots (≈2.8 × 10 5 cm −1 ) at their first exciton signifying the presence of giant oscillator strength and hence making them favorable candidates for next‐generation light‐emitting and light‐harvesting applications.
Intrauterine growth restriction – a population‐based study of the association with academic performance and psychiatric health (2014)

SGA had a small negative impact on academic achievements in adolescent girls, but not boys. There was no association between SGA and psychiatric problems in either gender.
Nysiad: practical protocol transformation to tolerate Byzantine failures (2008)

The paper presents and evaluates Nysiad, 1 a system that implements a new technique for transforming a scalable distributed system or network protocol tolerant only of crash failures into one that tolerates arbitrary failures, including such failures as freeloading and malicious attacks. The technique assigns to each host a certain number of guard hosts, optionally chosen from the available collection of hosts, and assumes that no more than a configurable number of guards of a host are faulty. Nysiad then enforces that a host either follows the system’s protocol and handles all its inputs fairly, or ceases to produce output messages altogether—a behavior that the system tolerates. We have applied Nysiad to a link-based routing protocol and an overlay multicast protocol, and present measurements of running the resulting protocols on a simulated network. 1
Crystallographic structure of ChitA, a glycoside hydrolase family 19, plant class IV chitinase from Zea mays (2014)

Maize ChitA chitinase is composed of a small, hevein-like domain attached to a carboxy-terminal chitinase domain. During fungal ear rot, the hevein-like domain is cleaved by secreted fungal proteases to produce truncated forms of ChitA. Here, we report a structural and biochemical characterization of truncated ChitA (ChitA ΔN), which lacks the hevein-like domain. ChitA ΔN and a mutant form (ChitA ΔN-EQ) were expressed and purified; enzyme assays showed that ChitA ΔN activity was comparable to the full-length enzyme. Mutation of Glu62 to Gln (ChitA ΔN-EQ) abolished chitinase activity without disrupting substrate binding, demonstrating that Glu62 is directly involved in catalysis. A crystal structure of ChitA ΔN-EQ provided strong support for key roles for Glu62, Arg177, and Glu165 in hydrolysis, and for Ser103 and Tyr106 in substrate binding. These findings demonstrate that the hevein-like domain is not needed for enzyme activity. Moreover, comparison of the crystal structure of this plant class IV chitinase with structures from larger class I and II enzymes suggest that class IV chitinases have evolved to accommodate shorter substrates.
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019)

Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but there are no current therapies to eliminate these tau species. We employed targeted protein degradation technology to convert a tau PET-probe into a functional degrader of pathogenic tau. The hetero-bifunctional molecule QC-01-175 was designed to engage both tau and Cereblon (CRBN), a substrate-receptor for the E3-ubiquitin ligase CRL4<sup>CRBN</sup>, to trigger tau ubiquitination and proteasomal degradation. QC-01-175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls, indicating specificity for disease-relevant forms. QC-01-175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated <i>MAPT</i>-knockout. This work demonstrates that aberrant tau in FTD patient-derived neurons is amenable to targeted degradation, representing an important advance for therapeutics.
Generalized TCP congestion avoidance and its effect on bandwidth sharing and variability (2002)

To model possible suggested changes in TCP window adaptation in response to randomized feedback, such as ECN (explicit congestion notification), we formulate a generalized version of the TCP congestion avoidance algorithm. We first consider multiple such generalized TCP flows sharing a bottleneck buffer under the assured service model and use a fixed point technique to obtain the mean window sizes and throughputs for the TCP flows, To further study how changes in the adaptation algorithm affect the variability in the throughput, we use an analytical-cum-numerical technique to derive the window distribution (and related statistics) of a single generalized flow under state-dependent randomized congestion feedback.
Distributed Fiber-Optic Chemical Sensor with Chemically Modified Plastic Cladding (1998)

A novel method for modification of the polymer cladding of an optical fiber has been developed for use in distributed chemical sensing. The usefulness of the new technique is illustrated by means of a distributed sensor for ammonium ions based on a 9 m long plastic-clad silica fiber modified with phenol red. The stability of the immobilized indicator made it possible, for the first time, to use a chemically modified fiber for the reversible detection of ammonium ions in highly alkaline solution (pH 11–14). The new sensor offers a broader dynamic range (four orders of magnitude) and shorter response time (30 s) than point sensors for ammonium ions reported in the past.
Advancing MIM Electronics: Amorphous Metal Electrodes (2010)

Amorphous metal thin films with atomically smooth surfaces are employed as contact layers for the realization of metal-insulator-metal (MIM) devices operating on the basis of controlled quantum mechanical tunneling through an ultrathin dielectric.
Stilbenoids fromHopea acuminata (2016)

Two resveratrol oligomers, a dimer (1) and a tetramer (2), were isolated from the ethyl acetate extracts of the leaves of Hopea acuminata along with vaticanol B, vaticaphenol A, vateriaphenol B, hopeaphenol, ε-viniferindiol, balanocarpol, and ampelopsin A. The structures of these compounds were established on the basis of spectroscopic data including two-dimentional nuclear magnetic resonance experiments. Compound 2, vaticanol B, vaticaphenol A, vateriaphenol B, hopeaphenol were found to inhibit protein splicing mediated by the Mycobacterium tuberculosis RecA intein in a nonspecific manner.
Strain-hardening behavior of polycarbonate in the glassy state (2000)

This paper presents an experimental characterization of the three-dimensional strain-hardening response of polycarbonate in the glassy state. Using a special mechanical conditioning technique, large homogeneous deformations were obtained in tension, compression, and shear. The experimental results are compared to a number of existing network models. It was found that the state-of deformation dependence of the strain-hardening response was adequately described by neo-Hookean behavior with a shear modulus G=26 MPa. Up to the deformations applied in this study, no sign of a finite extensibility of the entanglement network was observed.
Systematic Design Methodology of Broadband Doherty Amplifier Using Unified Matching/Combining Networks With an Application to GaN MMIC Design (2020)

This paper presents a new design methodology for broadband Doherty architecture using the three-port input and output networks technique. The proposed topology was developed to overcome the Doherty power amplifier (DPA) bandwidth limitations. The output three-port network performs the impedance matching from any load impedance to the optimum loads for both main and peaking transistors and also combines the power delivered from the two devices at any power ratio. On the other hand, the input-splitting network is proposed for matching the input impedances of the two transistors to the source impedance. The freedom in choosing the power division ratio of the input network enables us to achieve a tradeoff between efficiency and linearity. Also, it provides a way to accomplish the phase compensation using an arbitrary phase difference between the two branches of the Doherty power amplifier and thus, helps obviate the need of the highly bandwidth limiting offset lines found in the Doherty design. A two-stage broadband Doherty power amplifier is implemented using 0.25-um GaN HEMT MMIC process to validate the proposed topology. The fabricated DPA was measured under both continuous wave (CW) and modulated signal at different operating frequencies. Across 3.3-3.7 GHz, the implemented DPA delivers a maximum output power exceeding 42 dBm, power added efficiency (PAE) over 52 % at the peak power and over 38 % in the back-off state over the operating 400 MHz bandwidth. The fully integrated circuit has a chip-size of 4.4 mm × 3.5 mm.
Abstract 19600: Inhibition of Increased Thrombin Receptor Activity Attenuated Monocrotaline-induced Pulmonary Hypertension in Rats (2014)

Background and Objectives: Thrombin contracts the normal pulmonary artery (PA), while it relaxes the normal systemic artery endothelium-dependently. This unique property of pulmonary artery may contribute to the pathogenesis of pulmonary artery hypertension (PAH), because it frequently associated with thrombus formation and thrombotic pulmonary arteriopathy. However, the responsiveness to thrombin and its role in PAH remain unknown. We investigated, in monocrotaline (MCT)-induced PH in rats, the contractile responsiveness to thrombin and explored a therapeutic potential of antagonizing the thrombin receptors. Methods and Results: Three weeks after a single subcutaneous injection of MCT (60 mg/kg), MCT increased right ventricular (RV) systolic pressure (SP) (Normal: 23±3 vs. MCT: 74±4 mmHg, n=6~10, p Conclusions: This study provides the first evidence that the contractile response of PA to thrombin is increased in PAH. We conclude that antagonizing the increased thrombin receptor activity in PAH may serve as a novel therapeutic target.
A Digital Particle Image Velocimetry Investigation of Flow Field Instabilities of Axial-Flow Impellers (1997)

Digital particle image velocimetry (DPIV) has been used to examine the flow field in a vessel agitated by an axial-flow impeller in turbulent operation. Both a pitched-blade turbine and a high-efficiency impeller were studied. Time series analysis indicates that the flow field is not steady; rather, it is subject to transients with frequencies well below the blade passage frequency (periods ranging from 40 to over 300 impeller revolutions have been observed). This result has important implications for computational modeling because current descriptions of agitated vessels are based upon time-averaged flow fields with superimposed turbulence. This modeling approach may not accurately capture the mixing associated with the low-frequency phenomena observed in this study.
RECEIVE DIVERSITY (2003)

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Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia (2010)

Several classes of PHD enzyme inhibitors have been disclosed and several are currently in clinical trials for the development of small molecule-based therapeutics for the treatment of anemia.
Benefiting from Sobol Sequences Experiment Design Type for Model-based Calibration (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Design of Experiments (DOE) introduces a number of design types such as space filling design and optimal design. However, optimal design type is best for a system with high prior knowledge. Meanwhile, space-filling design is good for unknown systems, which is normal for engine calibration. It would be best to have a design that can support constructive model building, where a block of engine test is run for most of the day and followed by engine modeling at the end of the day. However, this needs separate space filling design for each day and separate design is susceptible to redundant test points. Among of the five space-filling design type, Sobol sequences and Halton sequences can support constructive model building due to the deterministic random sequence characteristic. When the model is good enough for system prediction, the remaining engine test can stop and proceed to model optimization. This made is possible because Sobol sequences is a quasi-random sequence, in which test points are scattered in a purely random manner. This behavior supports progressive augmentation of test sequences. Sobol sequences is typically use in statistical engine modeling. This paper discussed the fundamental building block of the Sobol sequences in experimental point of view in which the design benefits calibration engineers.&lt;/div&gt;&lt;/div&gt;
Data from Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages (2023)

&lt;div&gt;Abstract&lt;p&gt;Accumulation of tumor-associated macrophages (TAM) correlates with malignant progression, immune suppression, and poor prognosis. In this study, we defined a critical role for the cell-surface guidance molecule SEMA3A in differential proliferative control of TAMs. Tumor cell–derived SEMA3A restricted the proliferation of protumoral M2 macrophages but increased the proliferation of antitumoral M1, acting through the SEMA3A receptor neuropilin 1. Expansion of M1 macrophages &lt;i&gt;in vivo&lt;/i&gt; enhanced the recruitment and activation of natural killer (NK) cells and cytotoxic CD8&lt;sup&gt;+&lt;/sup&gt; T cells to tumors, inhibiting their growth. In human breast cancer specimens, we found that immunohistochemical levels of SEMA3A correlated with the expression of genes characteristic of M1 macrophages, CD8&lt;sup&gt;+&lt;/sup&gt; T cells, and NK cells, while inversely correlating with established characters of malignancy. In summary, our results illuminate a mechanism whereby the TAM phenotype is controlled and identify the cell-surface molecule SEMA3A as a candidate for therapeutic targeting. &lt;i&gt;Cancer Res; 76(11); 3166–78. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Evolution of nanocrystallinity in periodic mesoporous anatase thin films (2005)

angle was 0.7 or 0.9 times the critical angle for total reflection. Thus, a depth of 2 and 3 nm, respectively, of the top-layers was probed.
MODELING OF MAGNETRON TRANSMITTER FOR THE PROJECT X CW 1 GeV LINAC (2013)

Abstract Not Provided
Self-Protecting Disk Lubricant: D-MH2 (2017)

In disk drives of current generation, the thickness of the disk lubricant has been reduced to the level of a sub-monomolecular film. For a mono- or a sub-monomolecular film of a perfluoropolyether terminated with a primary hydroxyl unit at both ends, each lubricant molecular chain is chemically bound to the carbon substrate at both termini, and if it has a hydrocarbon sector inserted at its center, the hydrocarbon sectors would assemble at the top of the film. They are thus poised most aptly to react as a Lewis base (an electron donor) to the Lewis acid centers on the slider thus abating the Lewis acid-catalyzed lubricant degradation. A TOF-SIMS study of lubricant films of various thicknesses was performed. The study substantiated the envisaged lubricant posture.
Another look at security definitions (2013)

We take a critical look at security models thatare often used to give 'provable security'guarantees. We pay particular attention todigital signatures, symmetric-key encryption, andleakage resilience. We find that there has beena surprising amount of uncertainty about whatthe 'right' definitions might be. Evenwhen definitions have an appealinglogical elegance and nicely reflect certainnotions of security, they fail to take intoaccount many types of attacks and do not provide a comprehensivemodel of adversarial behavior.
Wave Field Synthesis: Implications for live music performances (2008)

cote interne IRCAM: Caulkins08a
Multi-path interferometric Josephson directional amplifier for qubit readout (2018)

We realize and characterize a quantum-limited, directional Josephson amplifier suitable for qubit readout. The device consists of two nondegenerate, three-wave-mixing amplifiers that are coupled together in an interferometric scheme, embedded in a printed circuit board. Nonreciprocity is generated by applying a phase gradient between the same-frequency pumps feeding the device, which plays the role of the magnetic field in a Faraday medium. Directional amplification and reflection-gain elimination are induced via wave interference between multiple paths in the system. We measure and discuss the main figures of merit of the device and show that the experimental results are in good agreement with theory. An improved version of this directional amplifier is expected to eliminate the need for bulky, off-chip isolation stages that generally separate quantum systems and preamplifiers in high-fidelity, quantum-nondemolition measurement setups.
ARSM: a cross-layer auto rate selection multicast mechanism for multi-rate wireless LANs (2007)

Multicast is an efficient paradigm for transmitting data from a sender to a group of receivers. According to the IEEE 802.11 standard, the multicast service is defined as an unreliable service, that is, it does not include the use of ACK frames. Furthermore, different to the unicast service, the multicast service makes use of a single rate out of the various rates included in the basic service set defined by the IEEE 802.11 standard. Even though various proposals have recently appeared in the literature addressing these issues, none of them has come out with a structured set of control mechanisms taking into account the varying conditions characterising the wireless channels as well as the requirements of various applications. A novel cross-layer auto rate selection multicast mechanism for multi-rate wireless LANs, namely auto rate selection for multicast, capable of adapting the data transmission to the varying conditions of the channel and taking into account the characteristics of various applications, is introduced. The simulation results show that our proposal outperforms the IEEE 802.11 standard and the mechanisms recently proposed in the literature.
Nmnat1 protects neuronal function without altering phospho‐tau pathology in a mouse model of tauopathy (2016)

Our results demonstrate that cytNmnat1 partially preserves neuronal function and decreases biochemically insoluble tau in a mouse model of chronic tauopathy without preventing tau phosphorylation, formation of soluble aggregates, or tau-induced inflammation and atrophy. Nmnat1 might thus represent a therapeutic target for tauopathies.
Microbial BOD Sensor Utilizing Thermophilic Bacteria (1989)

Abstract A microbial sensor for BOD(Biochemical Oxygen Demand) measurement was developed by utilizing thermophilic bacteria isolated from Japanese hot spring. the optimum temperature for BOD measurement
Time‐Lapse Microscopy Approaches to Track Cell Cycle Progression at the Single‐Cell Level (2005)

Time-lapse microscopy can be described as the repeated collection of a field of view from a microscope at discrete time intervals. The duration of the time interval defines the temporal resolution, which in turn characterizes the type of event detected. This unit describes the implementation of time-lapse microscopy to link initial cell cycle position during acute exposures to anti-cancer agents with anti-proliferative consequences for individual cells. The approach incorporates fundamental concepts arising from the ability to capture simple video sequences of cells from which it is possible to extract kinetic descriptors that reflect the interplay of mitosis and cell death in the growth of an unsynchronized tumor population. Utilizing a multi-well format enables the user to test different drug derivatives, multiple dose ranges, or cell cultures with unique genetic backgrounds. The objective of this unit is to present a generic methodology for capturing time-lapse sequences and subsequently mining the data for comprehensive event analysis.
High dynamic range video with synthesized gain control (2012)

HDR (High Dynamic Range) image processing is quite common, but there is much less study in HDR processing for videos. AGC (Automatic Gain Control), a general method for camera to adjust the brightness of image, has been used in most camera devices. This paper introduced a novel way of utilizing AGC function to produce HDR videos. Our approach does not need extra devices and no extra information is recorded during the whole process. In this paper, a new model called SGV is introduced which combines gain value and exposure settings and can be estimated from the intensities of frames. After processing, a video with uniform brightness in every frame can be obtained. As a byproduct, we can also get a HDR panoramic image at the same time.
Molecular determinants of allergen-induced effector cell degranulation (2006)

Background Allergen-induced effector cell degranulation is a key event in allergic inflammation and leads to early-phase symptoms, such as allergic rhinitis, conjunctivitis, urticaria, or bronchial asthma. Objective We sought to study molecular determinants of effector cell degranulation using a monoclonal IgE antibody specific for a peptide epitope of one of the most important respiratory allergens, the major grass pollen allergen Phl p 1, as a model system. Methods A hybridoma cell line producing a monoclonal IgE antibody against a Phl p 1–derived peptide, P1, was established by means of immunization of mice and used to sensitize rat basophil leukemia cells, which were exposed to P1 monomer, P1 dimer, and P1 polymer. Results It is demonstrated that the number of IgE epitopes on an allergen molecule and the concentration of allergen-specific IgE antibodies determine the extent of degranulation. The P1 monomer did not cause mediator release and prevented degranulation induced by polymeric P1. Conclusion Our results suggest that the number of IgE epitopes on an allergen molecule determines its allergenic activity and explains why increases of allergen-specific IgE levels make patients more sensitive to allergens. Allergen-derived monomeric structures isolated by means of combinatorial chemistry might be used to develop new therapeutic strategies for allergy. Clinical implications Our study reveals molecular factors that determine the immediate allergenic activity of allergens and hence influence clinical sensitivity to these allergens.
Optical cone beam tomography of Cherenkov‐mediated signals for fast 3D dosimetry of x‐ray photon beams in water (2015)

The results from this study demonstrate the use of optical cone beam computed tomography using CEF for the profiling of the imparted dose distribution from large area megavoltage photon beams in water.