gebhart/patrepeval huggingface dataset:
Health Care Costs Associated With Unrecognized Progression to Late-Stage Kidney Disease (2023)

Our findings indicate that costs associated with undiagnosed CKD extend to patients not yet requiring dialysis and highlight potential savings from earlier disease detection and management.
Dissociation of broadband high-frequency activity and neuronal firing in the neocortex (2019)

Broadband High-frequency Activity (BHA; 70-150 Hz), also known as "high gamma," a key analytic signal in human intracranial recordings is often assumed to reflect local neural firing (multiunit activity; MUA). Accordingly, BHA has been used to study neuronal population responses in auditory (1,2), visual (3,4), language (5), mnemonic processes (6-9) and cognitive control (10,11). BHA is arguably the electrophysiological measure best correlated with the Blood Oxygenation Level Dependent (BOLD) signal in fMRI (12-13). However, beyond the fact that BHA correlates with neuronal spiking (12, 14-16), the neuronal populations and physiological processes generating BHA are not precisely defined. Although critical for interpreting intracranial signals in human and non-human primates, the precise physiology of BHA remains unknown. Here, we show that BHA dissociates from MUA in primary visual and auditory cortex. Using laminar multielectrode data in monkeys, we found a bimodal distribution of stimulus-evoked BHA across depth of a cortical column: an early-deep, followed by a later-superficial layer response. Only, the early-deep layer BHA had a clear local MUA correlate, while the more prominent superficial layer BHA had a weak or undetectable MUA correlate. In many cases, particularly in V1 (70%), supragranular sites showed strong BHA in lieu of any detectable increase in MUA. Due to volume conduction, BHA from both the early-deep and the later-supragranular generators contribute to the field potential at the pial surface, though the contribution may be weighted towards the late-supragranular BHA. Our results demonstrate that the strongest generators of BHA are in the superficial cortical layers and show that the origins of BHA include a mixture of the neuronal action potential firing and dendritic processes separable from this firing. It is likely that the typically-recorded BHA signal emphasizes the latter processes to a greater extent than previously recognized.
ChemInform Abstract: Palladium‐Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Novel Method for Automatic Detection and Visualization of Non-Convulsive Seizures in ICU (P04.016) (2012)

Objective: To develop a method for automatically detecting non-convulsive seizures in ICU. Background Seizures are found in at least 8% of ICU patients; of these, 50-100% have only non-convulsive seizures detectable only by continuous EEG monitoring. Non-convulsive seizure duration and delay to treatment have been shown to be associated with increased mortality [1]. Seizure detection and management is problematic: a skilled electroencephalographer is not always available, generating a need for an automated seizure detection system. Design/Methods: Using a database of 179 ICU patients undergoing continuous EEG (148d) monitoring, we have developed a method that quantifies seizure-related evolution in a two-dimensional feature space consisting of EEG frequency and power. The method was evaluated in an independent data set of 53 ICU and epilepsy monitoring unit (EMU) patients (50d) [2]. All data were analyzed by an experienced electroencephalographer (BY), who marked the onsets and offsets of ten first seizures in each recording using commonly accepted seizure criteria [1]. Seizure detection was classified successful, if it took place within 15 minutes of the first marked seizure. Results: 10/19 seizure patients of the development data set were detected (false positive rates (FPR): median 0.00/hour, mean 0.34/hour). In the evaluation data set 6/8 seizure patients were detected (FPRs: 0.06/hour, 0.52/hour). Undetected patients were either in status epilepticus (SE) or had no seizures with evolutionary characteristics. Most false detections were caused by EMG. Conclusions: The method demonstrates good potential in detecting seizures with evolution, which further can be visualized in 2-D plane, facilitating seizure recognition at the bedside. To cover the full range of seizure disorders, the method needs to be integrated with methods suitable for spike detection and SE monitoring, such as WSE [3]. Further work will focus also on reducing FPR. Supported by: GE Healthcare, Finland OY. Disclosure: Dr. Tanner has received research support from GE Healthcare. Dr. Sarkela has received research support from GE Healthcare. Dr. Tolonen has received personal compensation for activities with GE Healthcare as an employee. Dr. Norton has nothing to disclose. Dr. Davies-Schinkel has nothing to disclose. Dr. Sharpe has nothing to disclose. Dr. Young has nothing to disclose.
Modeling of Wet Clutch Engagement Including a Thorough Experimental Validation (2005)

&lt;div class="htmlview paragraph"&gt;A detailed experimental validation has been carried out to point to limitations of static wet-clutch friction model for typical clutch engagement transients. The model accuracy can be increased by incorporating the fluid film dynamics, as done in the lumped-parameter dynamic clutch model developed at the University of Purdue. That model is extended herein in order to increase its accuracy especially in the case of grooved clutches. The extensions include a description of clutch actuator dynamics and introduction of an empirical scaling factor for the fluid film thickness state equation. More rigorous treatment of fluid dynamics for the grooved clutch is also presented.&lt;/div&gt;
Effects of type‐I and ‐II interferons on 90K antigen expression in ovarian carcinoma cells (1994)

Antigen 90K is produced by several tumor-cell lines and by patients with cancer. Its function has not yet been clarified, although recent reports suggest that it plays a role in the tumor-host relationship--for example by stimulation of natural killer and lymphokine-activated killer-cell activity. Previous studies have indicated that 90K expression may be under the influence of interferon-alpha. Here, we provide evidence that both interferon-alpha and -gamma can enhance the secretion of 90K and augment the level of specific mRNA expression in 3 ovarian carcinoma cell lines (OVCAR-3, HTB-77 and SKOV-6). However, interferon-gamma leads to depletion of cellular 90K whereas interferon-alpha increases both secreted and cellular 90K levels. In equimolar concentrations, Interferon-alpha was always superior to interferon-gamma in augmenting 90K protein or mRNA levels. Combinations of TNF with interferon-gamma were highly synergistic both in reducing cell proliferation and in increasing 90K secretion and mRNA expression. This synergism was seen to a lesser extent with interferon-alpha.
Hydrophilic Anthraquinone-Substituted Polymer: Its Environmentally Friendly Preparation and Efficient Charge/Proton-Storage Capability for Polymer–Air Secondary Batteries (2021)

Organic redox-active materials have been extensively studied as electrode-active materials to enable innovative battery designs with low environmental burdens. Facile condensation of 4,5-dihydroxyanthraquinone-2-carboxylic acid and poly(allylamine) in water produces hydrophilic 1,8-dihydroxyanthraquinone (DHA)-substituted poly(allylamine) (PDHA). Its high hydrophilicity originates from the poly(allylamine) main chain, and the distorted structure of the DHA inhibits intermolecular stacking of the polymer side chain. This made it possible to achieve a high electron and proton diffusion coefficient of 10–11 cm2/s, which is an order of magnitude higher than that of conventional redox polymers that have one-step, two-electron redox capability. The electrode, composed of appropriately synthesized PDHA, showed a full capacity of 140 mAh g–1 with excellent cyclability (>97% capacity maintenance after 500 cycles) and high rate capabilities (e.g., 120 C) in an acidic aqueous electrolyte under inert gas. These electrochemical properties were maintained even in air, making PDHA a promising candidate for a robust, electrode-active material. A polymer–air secondary battery was fabricated with PDHA, Pt/C, and a 0.5 M H2SO4 aqueous solution as the anode material, cathode material, and electrolyte, respectively, without any separator, inert gas, or strict sealing. This open-air battery displayed a discharge voltage of 1.05 V, with high cyclability greater than 500 cycles and high rate capabilities (e.g., 60 C), demonstrating a new battery concept and potential for large-scale applications.
Abstract 3743: Bioluminescent, non-lytic, real-time cell viability assay (2014)

Abstract Cell-based assay development for cancer drug discovery continues to advance toward more innovative methods that provide efficient workflow and meaningful data. Rapid, sensitive techniques that are non-lytic and therefore facilitate multiplexing with a wide range of assays allow more data to be gained per well and conserve precious samples. Real time measurement of cell viability also allows numerous measurements over time without the need for separate plates at each time point. Real time measurements allow unique analyses including interrogation of the timing of drug killing, identification of static vs toxic drug effects, and determination of the ideal time to multiplex an additional assay. Cancer drug discovery would benefit from novel assay technologies that allow real time measurements with multiplexing capability. We have developed a homogeneous, non-lytic, and bioluminescent method to analyze cell viability in real time through measurement of the reducing potential of the cell. The signal correlates with the number of viable cells making it well-suited for cytotoxicity studies. This Real Time Cell Viability Assay utilizes the NanoLuc luciferase enzyme, which is 100-fold brighter than either firefly (Photinus pyralis) or Renilla reniformis luciferase, and the novel substrate, furimazine. Together these reagents produce high intensity luminescence through an ATP-independent reaction. The assay can be performed in two formats, live cell endpoint or continuous read. The live cell endpoint method is sensitive, rapid, and enables extensive multiplexing opportunities due to the non-lytic measurement and signal depletion upon cell lysis. When the assay is set up in the continuous read format, the cell viability reagents can be added at the same time as cell plating, drug dosing, or at whatever point in the assay the researcher would like to start obtaining viability readings. The luminescent signal can be continually monitored from the same wells over an extended period of time to analyze cell viability in real time. This real time cell viability assay enables non-lytic cell viability measurements, extensive multiplexing options including both fluorescent and luminescent assays with no special filter requirements, straightforward normalization studies, conservation of precious samples and reagents, and a sensitive, real time measurement of cell viability. Citation Format: Sarah J. Duellman, Jolanta Vidugiriene, Wenhui Zhou, Jean Osterman, Ruslan Arbit, Laurent Bernad, Poncho Meisenheimer, James J. Cali. Bioluminescent, non-lytic, real-time cell viability assay. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3743. doi:10.1158/1538-7445.AM2014-3743
Renal Nerve Deafferentation Attenuates the Fall in GFR during Intravenous Infusion of Furosemide in Anesthetized Rats (2020)

The fall in GFR over 60 min of furosemide infusion is independent of volume depletion or activation of AT1 receptors but is largely dependent on renal afferent nerves.
Ferroelectric dielectric technology (2002)

Ferroelectric thin film, which is a kind of functional dielectric, especially provided with hysteresis characteristics in P-E curve, has drawn wide attention in the LSI field, because of its ideal features, like nonvolatility and fast programming operation at low voltage. From various points of view, for example, academic, industry and so on, basic studies have been drastically advanced for this decade. Recently, ferroelectric memory, called FeRAM, succeeds practically in volume production. At this stage, interestis in the theoretical prediction of life of the products and their application to logic devices. This paper has described a leading study on reliability physics and some applications of ferroelectric dielectric technology. Finally promising perspectives on the ferroelectric dielectric technology are shown.
Tendon Contraction After Cyclic Elongation Is an Age-Dependent Phenomenon (2014)

The age- and time-dependent contraction of tendons, elongated after repetitive loading, could result in transient alterations in the mechanobiological environment of tendon cells. This, in turn, could induce the onset of catabolic changes associated with the pathogenesis of tendinopathy. These results suggest the importance of allowing time for contraction between bouts of repetitive exercise and may explain why age is a predisposing factor in tendinopathy.
Performance Comparison of Probabilistically Shaped QAM Formats and Hybrid Shaped APSK Formats With Coded Modulation (2020)

We study and compare performance of probabilistically shaped (PS)-64QAM formats (with spectral efficiency ranging from 3.6 to 8.6 b/s/Hz) and coded modulation (CM)-64/16APSK formats with PS or geometric shaping (GS) or hybrid shaping (HS) with spectral efficiency ranging from 4.8 to 8.8 b/s/Hz. We show that a well-designed CM-64/16APSK format could exceed the performance of PS-64QAM formats by a small margin both in back-to-back and transmission. This was verified for transmission distances from 4,435 to 22,176 km using laboratory hardware and our implemented FEC. We show similar nonlinearity compensation (NLC) benefit for both PS and CM formats using 3-stage NLC schemes. The NLC benefit increases from 1.2 to 1.6 dB as the transmission distance increases from 4,435 to 9,504 km and then nearly saturates at ~1.6 dB after ~10,000 km. Furthermore, we experimentally demonstrate 71.6 Tb/s (7.36 b/s/Hz) using a CM-64/16APSK format and 70.3 Tb/s (7.22 b/s/Hz) with a PS-64QAM format over 6,970 km using C+L band EDFA testbed.
Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche (2019)

Abstract: The ability of breast cancer cells to interconvert between epithelial and mesenchymal states contributes to their metastatic potential. As opposed to cell autonomous effects, the impact of epithelial-mesenchymal plasticity (EMP) on primary and metastatic tumor microenvironments remains poorly characterized. Herein we utilize global gene expression analyses to characterize a metastatic model of EMP as compared to their non-metastatic counterparts. Using this approach we demonstrate that upregulation of the extracellular matrix crosslinking enzyme tissue transglutaminase-2 (TGM2) is part of novel gene signature that only emerges in metastatic cells that have undergone induction and reversion of epithelial-mesenchymal transition (EMT). Consistent with our model system patient survival is diminished when primary tumors demonstrate enhanced levels of TGM2 in conjunction with its substrate, fibronectin. Targeted depletion of TGM2 inhibits metastasis, while overexpression of TGM2 is sufficient to enhance this process. In addition to being present within cells, we demonstrate a robust increase in the amount of TGM2 and crosslinked fibronectin present within extracellular vesicle (EV) fractions derived from metastatic breast cancer cells. Confocal microscopy of these EVs suggests that FN becomes fibrillated on their surface via a TGM2 and Tesin1-dependent process. Upon in vivo administration, the ability of tumor-derived EVs to induce metastatic niche formation and enhance subsequent pulmonary tumor growth requires the presence and activity of TGM2. Finally, we develop a novel 3D model of the metastatic niche to demonstrate that education of pulmonary fibroblasts via pretreatment with tumor-derived EVs promotes subsequent growth of breast cancer cells in a TGM2-dependent fashion. Overall, our studies illustrate a novel mechanism through which EMP contributes to metastatic niche development and distant metastasis via tumor-derived EVs containing abberent levels of TGM2 and fibular FN.
Copper Oxide-Loaded Tin Dioxide Thin Film for Detection of Dilute Hydrogen Sulfide (1995)

The H 2 S sensing characteristics of SnO 2 thin films loaded with CuO were found to be much improved by reducing the film thickness. A 40-nm-thick film showed sensitivity as high as 20000 and 2000 to 1.5 and 0.3 ppm H 2 S in air, respectively, at 200° C, while the rate of response to 0.3 ppm H 2 S was rather slow.
Catalysis for Environmentally Benign Processing (1994)

A short overview of the types of catalytic processes that have shown progress in creating clean technology and are likely through continued material improvements to lead to new environmentally benign processing is presented. Chemistries involving solid acid/base catalysis, clean oxidation catalysis, catalysis in water, and asymmetric catalysis are discussed. Suggested reactions and catalytic materials for future clean processing are enumerated and unifying concepts for implementing catalysis for environmentally benign technologies are outlined.
An informatic model of human operator control (2003)

A preliminary informatic model has previously accounted for information processing that represents the movement time of the human operator. However, the human operator response time is the sum of both reaction time (RT) and movement time (MT). The human informatic model described herein now also accounts for the additional information processing that occurs during choice RT. The final human operator informatic model (accounting for both MT and RT) is a transfer function of a linear and time invariant system (LTI) and is of single input-single output (SISO) configuration and has been applied to describe a feedforward human control system.
Table S1 from Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer (2023)

&lt;p&gt;List of hubs and raw data for network analysis.&lt;/p&gt;
A Privacy Reinforcement Approach against De-identified Dataset (2011)

Protection of individual privacy has been a key issue for the corresponding data dissemination. Nowadays powerful search utilities increase the re-identification risk by easier information collection as well as validation than before. Despite there usually performs certain de-identified process, attackers may recognize someone from released dataset with which attacker-owned information is matched. In this paper, we propose an approach to mitigate the identity disclosure problem by generating plurals in a given dataset. The approach leverages decision tree to help selection of quasi-identifier and several masking techniques can be employed for privacy reinforcement. In addition to different privacy metrics applicability, the approach can achieve better trade-off between data integrity and privacy protection through flexible data masking.
Staging of metastatic pancreatic cancer in orthotopic mouse models by fluorescence laparoscopy is improved by an LED light source (2011)

Metildi, Cristina Angela MD; Kaushal, Sharmeela PhD; Hardamon, Chanae BSc; Cao, Hop Tran MD; Luiken, George A. MD; Hoffman, Robert M. PhD; Bouvet, Michael MD, FACS Author Information
Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure (2006)

[reaction: see text] The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atmospheric pressure is reported.
Immunohistochemical Localization of Blood-Retinal Barrier Breakdown Sites Associated with Post-Surgical Macular Oedema (1995)

Post-surgical macular oedema results from blood-retinal barrier breakdown, but it is not accompanied by structural abnormalities in the retinal vessels or retinal pigmented epithelium. Previous studies, using horseradish peroxidase in a primate model, suggested that leakage occurs primarily through this epithelium. This study was conducted to localize sites of the barrier breakdown in humans following different types of intra-ocular surgery and to compare them with eyes affected with ocular inflammatory disease, ocular infection, and choroidal melanoma. Paraffin sections of eyes were immunohistochemically stained for albumin to localize extravascular albumin, which was graded in a masked study. With aphakia/pseudophakia, penetrating keratoplasty, ocular inflammatory disease, ocular infection, and choroidal melanoma, barrier breakdown occurred primarily at the inner blood-retinal barrier (retinal vasculature), but leakage also occurred at the outer barrier (retinal pigmented epithelium). After retinal re-attachment surgery, the inner and outer blood-retinal barriers were equally compromised. Vascular leakage in the optic nerve head coincided with barrier failure in these disorders. The widespread pattern of blood-retinal barrier compromise with leakage at multiple sites suggests that soluble mediators are likely to play a role in postsurgical macular oedema, ocular inflammatory disease, and choroidal melanoma.
S. Cerevisiae Est1/H. sapiens SMG6 protein family members function in telomere metabolism (2005)

UPLIN
Stereochemical Structure of Polypropylene Obtained in the Presence of Half‐Sandwich Titanium Complexes (2004)

Abstract Summary: The polymerization of propene in the presence of CpTi(CH 3 ) 3 /B(C 6 F 5 ) 3 , at low temperature, affords prevailingly syndiotactic elastomeric polypropylene. In the presence of methylalumoxane (MAO) and under the same polymerization conditions, both CpTi(CH 3 ) 3 and CpTiCl 3 afford elastomeric polypropylene with a stereochemical structure ranging from prevailingly syndiotactic to prevailingly isotactic, depending on the concentration of MAO. A tentative rationalization of these results is provided. The methyl regions of the 13 C NMR spectra of polypropylenes obtained for different amounts of MAO (0.001 mol: top and 0.09 mol: bottom). magnified image The methyl regions of the 13 C NMR spectra of polypropylenes obtained for different amounts of MAO (0.001 mol: top and 0.09 mol: bottom).
Direct Conversion of Agarose into Alkyl Mono‐ and Disaccharide Surfactants Based on 3,6‐Anhydro L‐ and D‐Galactose Units (2021)

Abstract In this work, a new type of agaran‐derived non‐ionic surfactants has been prepared through the one‐pot transformation of agarose into 3,6‐anhydro L‐ and D‐galactose acetal monomers and dimers possessing one or two alkyl chains according to the cyclic or open form of the L‐ and D‐galactose units. The two steps process involves the butanolysis of agarose into butyl mono‐ and disaccharide 3,6‐anhydro L‐ and D‐galactose acetals promoted by the presence of Amberlyst‐15Dry, followed by the transacetalization with n ‐dodecanol using the same acid catalyst. The chemical structures of the alkyl mono‐ and disaccharide surfactants were fully characterized by 1D and 2D NMR experiments. Surface activities of these products in a pure form or as mixtures were investigated depending on their hydrophilicity/hydrophobicity and quite low values of superficial tensions (&lt;27 mN m −1 ) and sunflower seed oil/water interfacial tensions (∼5 mN m −1 ) were obtained.