gebhart/patrepeval huggingface dataset:
Calorie Restriction Improves Cognitive Decline via Up-Regulation of Brain-Derived Neurotrophic Factor (2014)

In metabolic syndrome (MetS), previous studies have suggested that cognitive decline is worsened. Among the factors associated with cognition, decreased brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. We previously reported that exercise training with calorie restriction yielded protection against cognitive decline via BDNF in the hippocampus of hypertensive rats. The aim of the present study was to determine whether or not calorie restriction results in protection against cognitive decline via BDNF and its receptor tropomyosin-related kinase B (TrkB) in the hippocampus of MetS model rats. We divided dietary-induced obesity-prone and hypertensive rats (OP), as metabolic syndrome model rats, into three groups, fed with a high fat diet (HF), treated with calorie restriction (CR) plus vehicle, and treated with CR and ANA-12 (a TrkB antagonist) (CR+A). After treatment for 28 days, body weight, insulin, fasting blood glucose, adiponectin, systolic blood pressure, and oxidative stress in the hippocampus were significantly lower, and BDNF expression in the hippocampus was significantly higher in CR and CR+A than in HF. Cognitive performance determined by the Morris water maze test was significantly higher in CR than in HF, whereas the benefit was attenuated in CR+A. In conclusion, calorie restriction protects against cognitive decline via up-regulation of BDNF/TrkB through an antioxidant effect in the hippocampus of dietary-induced obesity rats.
S4-Net: Geometry-Consistent Semi-Supervised Semantic Segmentation (2018)

We show that it is possible to learn semantic segmentation from very limited amounts of manual annotations, by enforcing geometric 3D constraints between multiple views. More exactly, image locations corresponding to the same physical 3D point should all have the same label. We show that introducing such constraints during learning is very effective, even when no manual label is available for a 3D point, and can be done simply by employing techniques from 'general' semi-supervised learning to the context of semantic segmentation. To demonstrate this idea, we use RGB-D image sequences of rigid scenes, for a 4-class segmentation problem derived from the ScanNet dataset. Starting from RGB-D sequences with a few annotated frames, we show that we can incorporate RGB-D sequences without any manual annotations to improve the performance, which makes our approach very convenient. Furthermore, we demonstrate our approach for semantic segmentation of objects on the LabelFusion dataset, where we show that one manually labeled image in a scene is sufficient for high performance on the whole scene.
Influence of Second Phase Particles on Thermal Conductivity of Bi Alloys (2022)

High-Bi alloys are being explored to understand their potential as replacement for high-Pb alloys in high-temperature die-attach applications. Thermal conductivity of these alloys is an important consideration for die-attach applications, where heat dissipation is necessary for reliable operation of the devices. Pure Bi has a thermal conductivity of about 8 W/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}\cdot \text{K}$ </tex-math></inline-formula> , which is the lowest among metals. The addition of the alloying elements to Bi had been explored to tailor its thermal, mechanical, and other physical properties. In this study, the role of Cu and Sb on the effective thermal conductivity of the resultant alloys was investigated. The thermal conductivities of these alloys in the bulk form and the three-layer die-attach form were measured using a flash diffusivity technique. Test specimens were developed to replicate a die-attach assembly between the Ni-metallized Si die and Cu substrate using the Bi– <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$x$ </tex-math></inline-formula> Sb–10Cu alloy (where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$x =10$ </tex-math></inline-formula> –20 wt%). The three-layered structure was modeled with the unknown diffusivity of an intermediate layer of the Bi alloy. The alloy microstructure comprises a composite of Bi–Sb solid solution filled with Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Sb intermetallic particles. The presence of these intermetallic phases is responsible for an effective increase in thermal conductivity of this alloy. With the optimized microstructure developed, the resultant thermal conductivity was obtained at <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim 24$ </tex-math></inline-formula> W/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{m}\cdot \text{K}$ </tex-math></inline-formula> , which is a threefold increase compared to pure Bi.
Supplementary Data Figure 2 from Functional Silencing of <i>HSD17B2</i> in Prostate Cancer Promotes Disease Progression (2023)

&lt;p&gt;HSD17B2 knockout in MDA-Pca-2b cells.&lt;/p&gt;
Vaccination experiments conducted with <i>Brugia malayi</i> (<i>Bm</i>) recombinant proteins <i>Bm</i>-RAL-2, <i>Bm</i>-103, the <i>Bm</i>-103—<i>Bm</i>-RAL-2 fusion protein and with <i>Bm</i>-103 + <i>Bm</i>-RAL-2 concurrently. (2016)

&lt;p&gt;Vaccination experiments conducted with &lt;i&gt;Brugia malayi&lt;/i&gt; (&lt;i&gt;Bm&lt;/i&gt;) recombinant proteins &lt;i&gt;Bm&lt;/i&gt;-RAL-2, &lt;i&gt;Bm&lt;/i&gt;-103, the &lt;i&gt;Bm&lt;/i&gt;-103—&lt;i&gt;Bm&lt;/i&gt;-RAL-2 fusion protein and with &lt;i&gt;Bm&lt;/i&gt;-103 + &lt;i&gt;Bm&lt;/i&gt;-RAL-2 concurrently.&lt;/p&gt;
The SDM Hand as a Prosthetic Terminal Device: A Feasibility Study (2007)

In this paper we discuss the potential of applying our concept for a robotic hand fabricated via Shape Deposition Manufacturing (SDM) as a prosthetic terminal device. Experimental results with the hand have shown a level of robustness, adaptability, and other performance properties as yet unseen in a robotic hand. Besides reliable performance, the hand is durable, is produced using a molding process that allows both for inexpensive mass production as well as a realistic appearance without the need for a cosmetic glove, and incorporates a simple design that requires only a single actuator for the eight active degrees of freedom. All of these factors make it a good candidate as a basis for either a body-powered or externally-powered prosthetic terminal device that is realistic, functional, robust, and inexpensive.
The Untimely in Globalization’s Time: Don DeLillo’s Cosmopolis (2018)

Globalization’s time is made possible through the elision or devaluation of other times and the attempt to control and foreclose the future through the technological acceleration of its own temporality. But global time remains haunted by traces of the non-global and the untimely. My paper will examine both the temporal framework capitalist globalization imposes on the world and the times outside that framework that, by their untimeliness, disturb globalization’s time. I will focus my discussion on Don DeLillo’s Cosmopolis, a novel that not only provides us with a description of capitalist globalization’s temporal regime but also tracks the disruptive emergence of the untimely. The untimely emerges as persistent anachronistic matter and the body in pain: both remain resistant to global capitalism’s desire to annul time itself. My paper, therefore, attempts to make a case for heterotemporality against capitalist globalization’s isochrony, which seeks to put an end to time.
An exact method for integration of the cylindrical wire kernel (2002)

The cylindrical wire kernel possesses a singularity which must be properly treated in order to evaluate the uniform current vector potential. Traditionally, the singular part of the kernel is extracted resulting in a slowly varying function which is convenient for numerical integration. This paper introduces a highly convergent exact series representation of the remaining singular integral which is valid except in the immediate vicinity of the singularity. This new exact expression, when used in conjunction with an existing exact expression which is valid for /spl rho/=a and z=0, provides an extremely accurate as well as efficient means for evaluating this integral.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
INTERACTIVE EFFECTS OF CREATIVITY AND IQ ON NINTH‐GRADE ACHIEVEMENT (1969)

The interactive effects of IQ and creativity upon ninth‐grade achievement were examined, with special focus upon the IQ threshold concept of Torrance He hypothesized that achievement is predicted better by IQ than by creativity below the IQ threshold, while IQ validity decreases as creativity validity increases above the threshold. This implies an IQ X Creativity interactive effect on achievement. If an IQ threshold exists, regression weights for IQ X Creativity interactive predictors should be statistically significant when included in multiple regression equations. Three creativity factor scores were estimated and were each multiplied by IQ to define three moderated or interactive predictor variables. A slight though statistically significant increase in validity resulted by adding the moderated variables to IQ and the three factor scores in multiple regression equations. Thus, there was weak support for the existence of an IQ threshold, but the regression of achievement on creativity decreased rather than increased with higher IQ.
The Effect of Electron-Donating Groups and Hydrogen Bonding on H2S Capture over Polyethylene Glycol/Amine Sites (2015)

The reversible adsorption of H2S on tetraethylenepentamine (TEPA) was investigated using attenuated total reflection infrared (ATR-IR) spectroscopy, mass spectrometry, and density functional theory (DFT). The in situ infrared method revealed H2S ability to selectively poison the TEPA amine active site by the formation of a strongly adsorbed species in the form of (HS–) NH3+-TEPA. In addition, the H2S–amine interaction, in the presence of oxygen, resulted in the oxidative degradation of the amine, indicated by the formation of an −NO2 species. The addition of polyethylene glycol (PEG) affects the H2S-amine interactions and prevents the amine site from oxidative degradation. Both experimental IR and DFT calculations revealed that PEG affected the electronic and geometric environment around the amine binding site through hydrogen bonding and electron-donating effects. The addition of PEG decreased the (+) charge of the ammonium ion site, effectively decreasing electrostatic anion–cation interaction of the strongly bound HS– species at the amine active site. This decrease in anion–cation interaction brought about by PEG resulted in lowering the binding energy of H2S on the amine site and decreasing the extent of oxidative degradation of the amine site. The addition of PEG also increased the adsorption capacity of the TEPA sorbent from 0.71 μmol H2S to 1.10 μmol H2S/g sorbent at 9.1 wt % PEG in the TEPA thin film, increasing the H2S adsorption capacity by 1.5 times. The qualitative aspect of this study suggests a way to tailor the amine active site using PEG to improve the adsorption capacity and regenerability of amine-based sorbents.
Stochastic signaling in biochemical cascades and genetic systems in genetically engineered living cells (2010)

Living cells, either prokaryote or eukaryote, can be integrated within whole-cell biochips (WCBCs) for various applications. We investigate WCBCs where information is extracted from the cells via a cascade of biochemical reactions that involve gene expression. The overall biological signal is weak due to small sample volume, low intrinsic cell response, and extrinsic signal loss mechanisms. The low signal-to-noise ratio problem is aggravated during initial detection stages and limits the minimum detectable signal or, alternatively, the minimum detection time. Taking into account the stochastic nature of biochemical process, we find that the signal is accompanied by relatively large noise disturbances. In this work, we use genetically engineered microbe sensors as a model to study the biochips output signal stochastic behavior. In our model, the microbes are designed to express detectable reporter proteins under external induction. We present analytical approximated expressions and numerical simulations evaluating the fluctuations of the synthesized reporter proteins population based on a set of equations modeling a cascade of biochemical and genetic reactions. We assume that the reporter proteins decay more slowly than messenger RNA molecules. We calculate the relation between the noise of the input signal (extrinsic noise) and biochemical reaction statistics (intrinsic noise). We discuss in further details two cases: (1) a cascade with large decay rates of all biochemical reactions compared to the protein decay rate. We show that in this case, the noise amplitude has a positive linear correlation with the number of stages in the cascade. (2) A cascade which includes a stable enzymatic-binding reaction with slow decay rate. We show that in this case, the noise strongly depends on the protein decay rate. Finally, a general observation is presented stating that the noise in whole-cell biochip sensors is determined mainly by the first reactions in the genetic system with weak dependence on the number of stages in the cascade.
Combined Ion Conductance and Atomic Force Microscope for Fast Simultaneous Topographical and Surface Charge Imaging (2018)

We report here an advanced approach for simultaneous and independent submicroscale imaging of local surface charge and topography using microchanneled cantilevers, also known as FluidFM nanopipette probes. These hollow cantilevers with a 300 nm opening are employed for ion current measurements that provide access to the local properties of the electrical double layer using the phenomenon of ion current rectification, while also taking advantage of the force sensing capabilities for accurate probe vertical positioning and topography imaging. The independent nature of this atomic force microscope (AFM) feedback opens up a possibility to significantly increase the sensitivity for probing local surface charges in a wider range of salt concentrations, especially in electrolytes of low ionic strength (below 10 mM), where classical local ion conductance measurements with glass nanopipettes would suffer from inaccuracies and instabilities, but where the electrical double layer extends further into the liquid medium and has stronger effect on the measured ion currents for charge imaging. We demonstrate that the measurements with FluidFM do not compromise the positioning accuracy and enable accurate and simultaneous topographical and charge imaging in contact mode (similar to AFM) at high scanning rates, approaching thousands of pixels per second, therefore overtaking state-of-the-art techniques for charge mapping by at least 2 orders of magnitude (the probes reach translation rates of 120 μm s<sup>-1</sup> equating to 2 ms per image pixel). We also reveal experimentally the physical limit of this high speed scanning, constrained by the rate of ion redistribution in surface-induced rectification required for double layer sensing and charge mapping.
A Voltage-Gated Ion Channel Based on a Bis-Macrocyclic Bolaamphiphile (1998)

The synthesis and characterization of a dissymmetric bis-macrocyclic bolaamphiphile ion channel is described. Bilayer-clamp experiments give rectified macroscopic current−voltage responses in which current is carried only at cis-negative potentials. Voltage and orientation-dependent irregular single-channel activity is also observed. Partial protonation of the carboxylate headgroups of the bolaamphiphile results in long-lived single channels with additional shorter-lived states of higher conductance. Single channels are also stabilized in the presence of barium cations. Vesicle experiments establish that transport activity is strongly cation- and concentration-dependent, suggesting the formation of aggregates. The voltage-gating process apparently involves the interaction of the applied potential with the molecular dipole of the bolaamphiphile which stabilizes an active aggregate.
HIV-1 Enhancing Effect of Prostatic Acid Phosphatase Peptides Is Reduced in Human Seminal Plasma (2011)

We recently reported that HIV-1 infection can be inhibited by innate antimicrobial components of human seminal plasma (SP). Conversely, naturally occurring peptidic fragments from the SP-derived prostatic acid phosphatase (PAP) have been reported to form amyloid fibrils called "SEVI" and enhance HIV-1 infection in vitro. In order to understand the biological consequence of this proviral effect, we extended these studies in the presence of human SP. PAP-derived peptides were agitated to form SEVI and incubated in the presence or absence of SP. While PAP-derived peptides and SEVI alone were proviral, the presence of 1% SP ablated their proviral activity in several different anti-HIV-1 assays. The anti-HIV-1 activity of SP was concentration dependent and was reduced following filtration. Supraphysiological concentrations of PAP peptides and SEVI incubated with diluted SP were degraded within hours, with SP exhibiting proteolytic activity at dilutions as high as 1:200. Sub-physiological concentrations of two prominent proteases of SP, prostate-specific antigen (PSA) and matriptase, could degrade physiological and supraphysiological concentrations of PAP peptides and SEVI. While human SP is a complex biological fluid, containing both antiviral and proviral factors, our results suggest that PAP peptides and SEVI may be subject to naturally occurring proteolytic components capable of reducing their proviral activity.
Flow Injection Electrochemical Quartz Crystal Microbalance with ICP-OES Detection: Recovery of Silver by Electrodeposition with Redox Replacement in a Flow Cell (2021)

We developed a new on-line hyphenated flow injection analysis technique (FI-EQCM-ICP-OES) that allows electrochemical deposition and stripping with mass detection and elemental analysis. This technique was used to study a new system for electrochemical recovery of silver from a 0.5 mM Ag + /5 mM Cu 2+ /0.5 M H 2 SO 4 solution by pulsed electrodeposition with redox replacement (EDRR) in a small flow cell. The metal ions in a 500 μ l sample are injected into the sulfuric acid carrier stream and deposited onto an electrochemical quartz crystal microbalance (EQCM) electrode housed in a 50 μ l flow cell. The deposits are subsequently stripped off electrochemically in the same cell and analyzed downstream in an ICP-OES. The stripped metal layer was found to be composed of Ag with no detectable Cu for a redox replacement time of 10 s, and 91 wt.% Ag–9 wt.% Cu for a redox replacement time of 5 s. Microscopy measurements demonstrated that the electrode was covered with silver particles, some of which contain Cu in the case of the 5 s replacement time. This technique allowed the study of mass changes on the electrode during electrodeposition and open circuit times in each EDRR cycle in flowing solutions.
1D Alignment of PEDOT in a Buckypaper for High‐Performance Solid Supercapacitors (2016)

Abstract A flexible solid‐state supercapacitor is prepared from carbon nanotube (CNT)‐based buckypaper after forming a thin layer of polyethylenedioxythiophene (PEDOT) on the surface of the CNTs in the paper. A highly conducting PEDOT phase is obtained by interfacial polymerization, in which polymerization is confined at the interface of two immiscible liquids. The hydrophilic interaction between the functionalized CNTs and the oxidizing agent (iron perchlorate, Fe(ClO 4 ) 3 ), which is located in the aqueous phase, and the restricted interaction of the oxidizing agent with the EDOT monomer in the organic layer at the immiscible interface play a vital role in establishing a uniform and aggregate‐free growth pattern of PEDOT on CNT. By carefully optimizing the amount of polymer in the paper, an electrode with a sheet resistance of 3.4 Ω □ −1 and equivalent series resistance of 0.95 Ω can be prepared. A thin and flexible solid‐state supercapacitor device with an overall thickness of 210 μm is made by using this paper as the electrodes and poly(vinyl alcohol)/lithium chloride as the gel electrolyte. The power density and energy density of the electrode are 9.94 W cm −3 and 8.85 mWh cm −3 , respectively. The device also delivers a high volumetric capacitance of 18 F cm −3 and areal capacitance of 354 mF cm −2 . The demonstrated strategy is scalable and hence the process can be conveniently applied to prepare large‐area PEDOT‐modified buckypapers in a short time.
Phase II study of fixed‐duration single‐agent ibrutinib in relapsed nodular lymphocyte‐predominant Hodgkin lymphoma: A report from the German Hodgkin Study Group (2022)

The peer review history for this article is available at https://publons.com/publon/10.1002/hon.2986. The analyzed data can be requested. Decisions regarding data sharing will be made on a case-by-case basis by the corresponding author considering data protection and other applicable regulations.
Distribution of trace impurities in microvolumes and analysis of concentration using laser sputtered neutral mass spectrometry (2021)

The performance of semiconductor devices has been improved by the miniaturization and the adoption of various materials. Together with this improvement, it has become difficult to measure the amount of injected impurities to control the electrical conductivity under the three-dimensional microstructure. As the volume decreases, the lower limit of the concentration that can be defined increases. In a 10-nm cubic region of silicon, there are approximately 64 000 atoms. One atom is approximately 16 ppm, and concentrations below that level cannot be defined. The limitation on the measurement accuracy of the PN junction position becomes unclear. Generally, the electrical characteristics of a semiconductor device are determined by the position of the PN junction and the concentrations in the P and N regions. In this paper, we elucidate the interface state of a minute PN junction. Based on the above, we will examine the lowest extent to which the concentration of impurities can be measured in a microvolume, with the current physical analysis technology, assuming ideal measurement conditions without any disturbance. Finally, we measure the sensitivity improvement of mass spectrometry using postionization technology with a femtosecond pulse infrared laser and demonstrate that it is possible to improve the performance of the impurity measurement.