gebhart/patrepeval huggingface dataset:
Performance of multiple access channels with asymmetric feedback (2008)

Channel state feedback at the transmitter is extensively used to increase the reliability of wireless transmissions. In multiuser systems, the downlink capacity to different users is often different due to the near-far effect. We capture this asymmetry by introducing an asymmetric feedback model where different users get a different amount of feedback from the base station. First, we derive the outage probability for the optimum maximum-likelihood receiver which forms an upper bound on the diversity-multiplexing performance. This is accompanied by the conditions under which these bounds can be achieved. Second, we analyze the performance of two popular suboptimal receivers: the spatial decorrelator and the successive interference cancellation receiver. As a special case, when there is no asymmetry, the performance matches feedback-based single-user performance in many scenarios.
Dispersion of Terahertz Surface Plasmon Polaritons on Metal Wire Waveguides (2006)

Dispersive behavior of terahertz surface waves on metal wires is experimentally and theoretically studied. This behavior is different from that of surface plasmon polaritons on planar metal surfaces or on metal nanorods at optical frequencies.
A Monolithically-Integrated Chip-to-Chip Optical Link in Bulk CMOS (2015)

Silicon-photonics is an emerging technology that can overcome the tradeoffs faced by traditional electrical I/O. Due to ballooning development costs for advanced CMOS nodes, however, widespread adoption necessitates seamless photonics integration into mainstream processes, with as few process changes as possible. In this work, we demonstrate a silicon-photonic link with optical devices and electronics integrated on the same chip in a 0.18 µm bulk CMOS memory periphery process. To enable waveguides and optics in process-native polysilicon, we introduce deep-trench isolation, placed underneath to prevent optical mode leakage into the bulk silicon substrate, and implant-amorphization to reduce polysilicon loss. A resonant defect-trap photodetector using polysilicon eliminates need for germanium integration and completes the fully polysilicon-based photonics platform. Transceiver circuits take advantage of photonic device integration, achieving 350 fJ/b transmit and 71 µA pp BER = 10 -12 receiver sensitivity at 5 Gb/s. We show high fabrication uniformity and high-Q resonators, enabling dense wavelength-division multiplexing with 9-wavelength 45 Gb/s transmit/receive data-rates per waveguide/fiber. To combat perturbations to variation- and thermally-sensitive resonant devices, we demonstrate an on-chip thermal tuning feedback loop that locks the resonance to the laser wavelength. A 5 m optical chip-to-chip link achieves 5 Gb/s while consuming 3 pJ/b and 12 pJ/bit of circuit and optical energy, respectively.
The Epigenetic Modifier PRDM5 Functions as a Tumor Suppressor through Modulating WNT/β-Catenin Signaling and Is Frequently Silenced in Multiple Tumors (2011)

PRDM5 functions as a tumor suppressor at least partially through antagonizing aberrant WNT/β-catenin signaling and oncogene expression. Frequent epigenetic silencing of PRDM5 is involved in multiple tumorigeneses, which could serve as a tumor biomarker.
Millimeter Wave Channel Estimation using Data-Aided DoA Estimation (2018)

In this paper, we study channel estimation for multiuser millimeter wave (mmWave) systems. Since most conventional channel estimation schemes rely entirely on pilot signals, such methods cannot accurately estimate mmWave channels with low signal-to-noise ratio (SNR). To address this challenge, a direction of arrival (DoA)-assisted channel estimation scheme exploiting the sparsity of mmWave channels is developed. The proposed scheme utilizes data symbols as well as the pilot signals to estimate DoA of effective paths, and the estimated DoA information is used to suppress the noise given that the number of effective path directions is much smaller than the number of antennas. Furthermore, it is shown that sparse Bayesian learning (SBL) approach is suitable for DoA estimation in mmWave communications scenarios where signals from different angles are highly correlated as a result of multipath propagation, and a low complexity SBL algorithm for this setup is derived. By utilizing data symbols and adopting the SBL approach, the proposed scheme can identify the directions of effective path even in low SNR regime, enabling accurate estimation of mmWave channels.
Hybrid Algorithm For Hammerstein System Identification Using Genetic Algorithm And Particle Swarm Optimization (2009)

This paper presents a method of model selection and identification of Hammerstein systems by hybridization of the genetic algorithm (GA) and particle swarm optimization (PSO). An unknown nonlinear static part to be estimated is approximately represented by an automatic choosing function (ACF) model. The weighting parameters of the ACF and the system parameters of the linear dynamic part are estimated by the linear least-squares method. On the other hand, the adjusting parameters of the ACF model structure are properly selected by the hybrid algorithm of the GA and PSO, where the Akaike information criterion is utilized as the evaluation value function. Simulation results are shown to demonstrate the effectiveness of the proposed hybrid algorithm.
Silicon photonic link in CMOS quilt package (2012)

A multifunction low-power, high-speed silicon photonic chip consisting of a resonant modulator and germanium detector is quilt packaged with CMOS receiver and driver electronics. Experimental data demonstrates this new route for intimate 2D-integration.
Optimizing matching and analysis combinations for estimating causal effects (2016)

Matching methods are common in studies across many disciplines. However, there is limited evidence on how to optimally combine matching with subsequent analysis approaches to minimize bias and maximize efficiency for the quantity of interest. We conducted simulations to compare the performance of a wide variety of matching methods and analysis approaches in terms of bias, variance, and mean squared error (MSE). We then compared these approaches in an applied example of an employment training program. The results indicate that combining full matching with double robust analysis performed best in both the simulations and the applied example, particularly when combined with machine learning estimation methods. To reduce bias, current guidelines advise researchers to select the technique with the best post-matching covariate balance, but this work finds that such an approach does not always minimize mean squared error (MSE). These findings have important implications for future research utilizing matching. To minimize MSE, investigators should consider additional diagnostics, and use of simulations tailored to the study of interest to identify the optimal matching and analysis combination.
Sound speed estimation in layered media using the angular coherence of plane waves (2020)

We present a refraction-corrected sound speed reconstruction technique for layered media based on the angular coherence of plane waves. Previous work has successfully shown that sound speed estimation and refraction- corrected image reconstruction can be achieved using the coherence of full-synthetic aperture channel data. However, methods for acquiring the full-synthetic aperture dataset require a large number of transmissions, which can confound sound speed estimation due to the scatterer motion between transmit events, especially for in-vivo application. Furthermore, sound speed estimation requires producing full-synthetic aperture coherence images for each trial sound speed, which can make the overall computational cost quite burdensome. The angular coherence beamformer, initially devised as a quicker alternative to the more conventional spatial coherence beamformer, measures coherence between fully-beamformed I/Q channel data for each plane wave as opposed to the receive channel data prior to receive beamforming. As a result, angular coherence beamforming can significantly reduce the computation time needed to reconstruct a coherence image by taking advantage of receive beamforming. Previous work has used the coherence maximization of full-synthetic aperture channel data to perform sound speed estimation. By replacing spatial coherence with angular coherence, we apply a similar methodology to channel data from plane-waves to significantly reduce the computational cost of sound speed estimation. This methodology has been confirmed by both simulated and experimental channel data from plane waves.
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? (2009)

1. It is well known that respiration markedly modulates the sympathetic nervous system. Interactions between pontine and medullary neurons involved in the control of sympathetic and respiratory functions are the main mechanism underlying the respiratory related oscillations in sympathetic nerve activity. 2. Recently, in rats treated with chronic intermittent hypoxia, we demonstrated that alterations in respiratory pattern may drive increased sympathetic outflow and hence the development of systemic hypertension. These experiments, performed in the in situ working heart-brain stem preparation, raise the possibility that enhanced central coupling between respiratory and sympathetic activities could be a potential mechanism underpinning the development and/or the maintenance of neurogenic hypertension. 3. In the present review, we discuss the neural basis of the enhanced entrainment between respiratory and sympathetic neurons in the brain stem that can be induced by chronic intermittent hypoxia and the possible implications of these mechanisms in the genesis of sympathetic overactivity and, consequently, hypertension.
Fully flexible terahertz Bragg reflectors based on titania loaded polymers (2008)

We demonstrate fully flexible, high performance terahertz Bragg reflectors and filters based on TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -loaded polymers. Broadband terahertz reflection measurements with corresponding transfer matrix simulations are shown and the effect of curvature is analyzed.
The Isolation of cDNAs from OATL1 at Xp11.2 Using a 480-kb YAC (1993)

Using an ornithine-delta-aminotransferase (OAT) cDNA, we identified five YACs that cover two nonadjacent OAT-related loci in Xp11.2-p11.3, designated OATL1 (distal) and OATL2 (proximal). Because several retinal degenerative disorders map to this region, we used YAC2 (480 kb), which covers the most distal part of OATL1, as a probe to screen a retinal cDNA library. From 8 x 10(4) plaques screened, we isolated 13 clones. Two were OAT cDNAs. The remaining 11 were divided into eight groups by cross-hybridization. Groups 1-4 contain cDNAs that originate from single-copy X-linked genes in YAC2. Each has an open reading frame of > 500 bp and detects one or more transcripts on a Northern blot. The gene for each was sublocalized and ordered in YAC2. The cDNAs in groups 5-8 contained two or more Alu sequences, had no open reading frames, and did not detect transcripts. The cDNAs from groups 1-4 provide expressed sequence tags and identify candidate genes for the genetic disorders that map to this region.
Prediction of the Structure of Complexes Comprised of Proteins and Glycosaminoglycans Using Docking Simulation and Cluster Analysis (2007)

A typical docking simulation provides information on the structure of ligand-receptor complexes and their binding affinity in terms of a docking energy. We have developed a potent method combining a docking simulation with cluster analysis to extract adequate docking structures from the many possible output structures of the simulation. First, we tried to predict the structure of basic fibroblast growth factor (bFGF) bound to heparin, using the docking simulation program AutoDock 3.0. Two X-ray crystal structures had already been obtained for bFGF. One was a complex of the protein and heparin, a kind of glycosaminoglycan, and the other, only the protein itself, hereafter called a simplex. We docked a heparin molecule onto the protein simplex and generated many trial structures for the bFGF-heparin complex. The structures of those docked complexes were optimized through energy minimization by AMBER8. Although neither the docking energy calculated by AMBER8 nor that calculated by AutoDock 3.0 could be used satisfactorily by themselves to select a proper heparin-binding complex from the output structures, the majority of the structures generated by AutoDock 3.0 were fairly close to each other in atom geometry, and the averaged geometry over these structures was also close to that of the crystal. Hence, we utilized only the atom geometry for evaluation and carried out cluster analysis with the collection of geometries. This procedure enabled selection of a structure considerably close to the crystal's. We applied this approach to two other heparin-binding proteins: antithrombin and annexin V. Two crystal structures, a complex and a simplex, had been elucidated for these proteins as well as for bFGF. Our trials gave an exact prediction of the heparin-binding structures of these proteins, showing the approach in this study is effective in studying the docking of ligands that have a variety of docking conformations due to the presence of multiple rotatable bonds and charged chemical groups.
Effects of gas pockets on high-intensity focused ultrasound field (2011)

The paper describes experimental and numerical studies of the effects of gas pockets on a high-intensity focused ultrasound (HIFU) field. Air bubbles ranging from 0.8 to 2.4 mm in radius were produced in transparent polyacrylamide tissue-mimicking gels. A single-element 3.5-MHz HIFU transducer was used to sonicate the gel phantoms. The changes in the HIFU beam pattern for air bubbles at different positions were visualized by the Schlieren method. Quantitative measurements of pressure at the HIFU focus by a calibrated needle hydrophone showed considerable reduction in the focal pressure with the presence of an air pocket. The presence of a single 1.2-mm-radius air bubble, at a 5 mm axial pre-focal position, reduced the focal intensity by 50% and increased the lateral focal dimension by 50%. For air bubbles at pre-focal position close to the focus, lesion formation was observed not at the theoretical focus, but in front of the air bubble and the air bubble became a barrier for the post-focal ultrasound propagation. The effects of reflection were simulated numerically and were compared with the experiments. The results can be used as guidelines for evaluation of potential safety concerns produced by trapped gas-pockets in various HIFU therapies.
Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. (1994)

The 2-amino-3-benzoylthiophene derivative PD 81,723 is an allosteric enhancer of agonist binding to brain A1 adenosine receptors. One aim of this study was to characterize and contrast the effects of PD 81,723 on the A1 receptor-mediated negative dromotropic and A2a receptor-mediated vasodilatory actions of adenosine and of a nonmetabolizable and unselective N6-(3-pentyl)adenosine derivative. A second aim was to determine the mechanism of action of PD 81,723. In guinea pig isolated hearts, PD 81,723 potentiated the adenosine and the N6-(3-pentyl)adenosine derivative-induced prolongations of the stimulus-to-His bundle (S-H) interval in a concentration-dependent manner. PD 81,723 (30 mumol/L) decreased the EC50 value for adenosine to prolong the S-H interval by ninefold from 7.4 +/- 1.2 to 0.8 +/- 0.1 mumol/L but did not increase the content of adenosine in cardiac effluent. PD 81,723 (30 mumol/L) increased the specific binding of the A1 agonist [3H]cyclohexyladenosine ([3H]CHA) to human atrial and guinea pig atrial and brain membranes by 38%, 78%, and 300%, respectively. PD 81,723 also increased the fraction of A1 receptors in the high-affinity binding state by an average of 56 +/- 13%. The dissociation rate of [3H]CHA from guinea pig brain membranes was decreased in the presence of PD 81,723 (10 mumol/L) from 0.55 +/- 0.01/min to 0.35 +/- 0.01/min. PD 81,723 did not alter the binding of the A1 antagonist [3H]cyclopentyldipropylxanthine to guinea pig brain membranes. The IC50 values for 5'-guanylylimidodiphosphate to reduce specific binding of [3H]CHA to guinea pig cardiac and brain membranes were increased from 1.5 +/- 0.2 and 2.0 +/- 0.2 mumol/L in the absence of PD 81,723 to 10 +/- 3.3 and 18 +/- 0.5 mumol/L, respectively, in the presence of PD 81,723 (30 mumol/L). PD 81,723 did not potentiate the coronary vasodilatory actions of the N6-(3-pentyl)adenosine derivative. Specific binding of the A2a agonist [3H]CGS 21680 to brain membranes and the nucleoside transporter ligand [3H]nitrobenzylthioinosine to cardiac membranes was unchanged in the presence of PD 81,723. The results suggest that PD 81,723 specifically potentiates the action of adenosine on A1 receptors by stabilizing receptor-G protein interactions in the presence of agonists.
Kinetik der Reaktion von CO2 und OH–-Ionen in wässrigen Lösungen (2002)

No translation.
Cyproheptadine Versus Propranolol for the Treatment of Acute Neuroleptic-Induced Akathisia: A Comparative Double-Blind Study (2001)

The purpose of this study was to investigate the efficacy of cyproheptadine, an antiserotonergic agent, in the treatment of neuroleptic-induced akathisia (NIA), as compared with propranolol, the current gold standard. In a double-blind trial, 30 patients with schizophrenia and NIA received either cyproheptadine 16 mg/day (N = 18) or propranolol 80 mg/day (N = 12) for 4 days, followed by 3 days without any anti-NIA treatment. The Barnes Akahisia Scale, Simpson-Angus Extrapyramidal Effects Rating Scale, and Brief Psychiatric Rating Scale were used to assess the severity of NIA, parkinsonism, and psychosis, respectively. In both groups, the severity of NIA decreased significantly over time (cyproheptadine, -46%; propranolol, -42%), with no significant intergroup difference. The NIA symptoms worsened significantly when cyproheptadine and propranolol were discontinued. We conclude that cyproheptadine 16 mg/day is as effective as propranolol for the treatment of acute NIA. The antiakathisic effect of cyproheptadine may be mostly attributable to its serotonin antagonistic activity.
Millimeter-wave-lightwave converters using X-Cut Ti: LiNbO3 waveguide suspended to patch antennas embedded with a gap on low-k dielectric substrate (2013)

The demand for high quality multimedia services by mobile devices increases continuously [1]. To meet the demand, large capacity of wireless communication is required. The capacity can be enhanced using millimeter- wave (MMW) carriers with large bandwidth. However, one drawback of the MMW carrier is high transmission losses in the free space. It can be used to realize short range and indoor wireless communication. The small coverage area can be expanded by adopting radio-over-fiber (ROF) technology. The key device in the ROF technology is MMW to lightwave (LW) converters.
Data from Efficacy of Systemically Administered Mutant Vesicular Stomatitis Virus (VSVΔ51) Combined with Radiation for Nasopharyngeal Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck region that is associated with EBV latency. Curative treatments for NPC achieve modest survival rates, underscoring a need to develop novel therapies. We evaluated the therapeutic potential of a mutant vesicular stomatitis virus (VSVΔ51) as single treatment modality or in combination with ionizing radiation (RT) in NPC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; MTS assay was used to assess cell viability &lt;i&gt;in vitro&lt;/i&gt;; apoptosis was measured using propidium iodide staining and caspase activation. &lt;i&gt;In vivo&lt;/i&gt; experiments were conducted using tumor-bearing nude mice with or without local RT (4 Gy). Apoptosis was assessed in excised tumor sections with terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling staining.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Our data showed that NPC cells are exquisitely sensitive to VSVΔ51 oncolysis, which correlated with the presence of EBV. Efficacy of VSVΔ51 against NPC cells was further augmented when combined with RT. A single systemic injection of VSVΔ51 achieved 50% survival in treated mice, which increased to 83% when combined with local tumor RT. In addition to induction of apoptosis, an antiangiogenic effect of VSVΔ51 was observed &lt;i&gt;in vivo&lt;/i&gt;, suggesting a novel tumoricidal mechanism for VSVΔ51. This virus also prevented growth of NPC sphere-forming cells &lt;i&gt;in vitro&lt;/i&gt;, showing potential utility in targeting NPC-initiating cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our data represent the first report showing that EBV-positive NPC cells are exquisitely sensitive to VSVΔ51 oncolysis and documenting the successful utilization of this combinatorial regimen as a novel curative therapeutic strategy for NPC.&lt;/p&gt;&lt;/div&gt;
Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms (2020)

Waveform had substantial effects on block thresholds, and the amplitude relative to block threshold had substantial effects on onset response. These data inform choice of waveform in subsequent studies and clinical applications, enhance effective use of block in therapeutic applications, and facilitate the design of parameters that achieve block with minimal onset responses.
Association of Ebola Virus Matrix Protein VP40 with Microtubules (2005)

Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for many viruses. A variety of viral proteins have been identified that interact with microtubules, either directly or via a microtubule-associated motor protein. Here, we report that Ebola virus associates with microtubules via the matrix protein VP40. When transfected into mammalian cells, a fraction of VP40 colocalized with microtubule bundles and VP40 coimmunoprecipitated with tubulin. The degree of colocalization and microtubule bundling in cells was markedly intensified by truncation of the C terminus to a length of 317 amino acids. Further truncation to 308 or fewer amino acids abolished the association with microtubules. Both the full-length and the 317-amino-acid truncation mutant stabilized microtubules against depolymerization with nocodazole. Direct physical interaction between purified VP40 and tubulin proteins was demonstrated in vitro. A region of moderate homology to the tubulin binding motif of the microtubule-associated protein MAP2 was identified in VP40. Deleting this region resulted in loss of microtubule stabilization against drug-induced depolymerization. The presence of VP40-associated microtubules in cells continuously treated with nocodazole suggested that VP40 promotes tubulin polymerization. Using an in vitro polymerization assay, we demonstrated that VP40 directly enhances tubulin polymerization without any cellular mediators. These results suggest that microtubules may play an important role in the Ebola virus life cycle and potentially provide a novel target for therapeutic intervention against this highly pathogenic virus.