gebhart/patrepeval huggingface dataset:
Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma (2022)

These data provide a robust rationale for future clinical studies with mRNA-based multifunctional CAR T cells to treat malignant brain tumors.
Depth profiling of proton exchanged LiNbO3 waveguides by micro-Raman spectroscopy (1993)

Z-cut LiNbO3 wafers were proton exchanged (PE) with pyrophosphoric acid. The polished edges provided a side view of the exchanged region. The region was probed by micro-Raman spectroscopy by stepping a 488.0 nm laser at intervals as small as 0.2 μm across the edge face starting below the exchanged region and moving towards the wafer surface, thereby traversing the PE region. Profiling revealed significant changes, in the 125–800 cm−1 and 3200–3600 cm−1 frequency ranges. The PE region expanded after annealing at 300 °C indicating proton penetration into the wafer. Continued annealing resulted in the progressive recovery of spectral characteristics resembling unexchanged lithium niobate. Micro-Raman profiles provide spectroscopic information regarding which vibrational modes are affected by the exchange and the annealing processes as a function of depth.
EBCT DYNAMIC IMAGING OF THE SHOULDER RHYTHM (2005)

The motion of the shoulder complex, the scapulo-humero-thoracic rhythm, is an equilibrium between transmission of loads and positioning of the upper limb. This rhythm, which can be described by 12 spatial variables, is either responsible for, or affected by the genesis of shoulder pathology and trauma. Thus, imaging the articulations of the shoulder through a global range of motion is essential in aiding diagnosis, management decisions and interpreting operative outcome. As such, the objective of this study was to dynamically image the scapulo-humero-thoracic rhythm. The subjects were seated between the toroid of the scanner and maximally slewn table on a customised tripod which both protects the target rings and provides a degree of comfort. Each subject was asked to carryout 4 movements; adduction to abduction in the scapular plane, internal rotation to external rotation at 0° and 90° abduction and flexion to extension. Each movement was carried out over a period of 5 seconds, enabling the acquisition of 20 volumes per movement. Electron Beam Computed Tomography (EBCT) enables the scanning of a number of contiguous slices, each taking 50 msec. Previously this has facilitated real-time imaging and rendering of both cardiopulmonary function and colonography. A GE Imatron EBCT C300 scanner was used with a multislice sequence imaging protocol to collect 8 transaxial slices per volume by sweeping an x-ray beam sequentially over 4 tungsten target rings and recording x-ray intensity via two fixed detector rings after the reflected beam passes through the body. Each slice was post-processed by semi-automatic segmention using Amira software, and reconstructed to produce three-dimensional volumes of the humerus, scapula, clavicle and selected ribs. Anatomical landmarks were then identified and the normal rhythm of the shoulder was described. In conclusion, EBCT provides a quick and efficient method for direct realtime dynamic imaging of the shoulder girdle under normal conditions, the first time this has been achieved to the best of our knowledge. Not only do these reconstructions provide further input matter for preexisting and future computational shoulder models, but estabilishes an initial baseline for further clinical experience. As such, we hypothesise the ability of this modalitiy to image pathological and traumatic disruption to shoulder rhythm. The potential clinical application of this tool would include imaging of traumatic instability and impingement, facilitated by some minor ergonomic alterations to the apparatus.
OpenStereo (2007)

Recent years have promoted important evolution in remote sensing, specially taking into consideration quality improvements on satellites that are now capable of obtaining more detailed and accurate observation and producing stereoscopic views. Following market laws, once the level of detail increases the associated costs also rise. In order to take advantage of modest dataset acquisition costs the OpenStereo library (a free, open source, multiplatform, flexible and robust library for stereoscopy) is applied with the purpose of converting satellite images and similar types of geodata acquirers into stereoscopic views.
Fluorescence Polarization Assay for Small Molecule Screening of FK506 Biosynthesized in 96-Well Microtiter Plates (2017)

The fluorescence polarization (FP) assay has been widely used to study enzyme kinetics, antibody-antigen interactions, and other biological interactions. We propose that the FP assay can be adapted as a high-throughput and potentially widely applicable screen for small molecules. This is useful in metabolic engineering, which is a promising approach to synthesizing compounds of pharmaceutical, agricultural, and industrial importance using bioengineered strains. There, the development of high-yield strains is often a costly and time-consuming process. This problem can be addressed by generating and testing large mutant strain libraries. However, a current key bottleneck is the lack of high-throughput screens to detect the small molecule products. The FP assay is quantitative, sensitive, fast, and cheap. As a proof of principle, we established the FP assay to screen for FK506 (tacrolimus) produced by Streptomyces tsukubaensis, which was cultivated in 96-well plates. An ultraviolet mutagenized library of 160 colonies was screened to identify strains showing higher FK506 productivities. The FP assay has the potential to be generalized to detect a wide range of other small molecules.
A 250-Mb/s 32*32 CMOS crosspoint LSI for ATM switching systems (1990)

A 32*32 crosspoint LSI and a time-slot controlled asynchronous-transfer-mode (ATM) switch architecture utilizing the LSI are presented. The ATM switch, which is classified as an input-buffer-type ATM switch, enables 99% throughput and broadcasting capability. The crosspoint LSI is characterized by the bit-map oriented and pipelined connection control method which can switch and broadcast 160-Mb/s ATM cells, 32*32 switch cells which have less parasitic capacitance, and emitter-coupled-logic (ECL) compatible interfaces which are compatible with a 160-MHz broadband ISDN data rate. The LSI has been fabricated by a 1- mu m CMOS process. The chip size is 7.4 mm*7.4 mm. According to the evaluation, operation at 250 Mb/s is confirmed. 1.2-W power consumption is observed at 160-Mb/s operating condition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Challenges in Development of Sub-10 nm Resist Materials (2016)

In the sub-10 nm resist processes for the high volume production of semiconductor devices, the suppression of stochastic phenomena is a critical issue. In this study, the resist processes of line-and-space patterns with sub-10 nm half-pitches were calculated by the Monte Carlo method on the basis of the sensitization and reaction mechanisms of chemically amplified extreme ultraviolet (EUV) resists. The effects of thermalization distance and effective reaction radius for deprotection on line edge roughness (LER) and stochastic defect generation were evaluated for the different halt-pitches in the sub-10 nm region.
Modeling multiple communities of interest for interactive simulation and gaming: the dynamic adversarial gaming algorithm project (2007)

Nowadays, there is an increasing demand for the military to conduct operations that are beyond traditional warfare. In these operations, analyzing and understanding those who are involved in the situation, how they are going to behave, and why they behave in certain ways is critical for success. The challenge lies in that behavior does not simply follow universal/fixed doctrines; it is significantly influenced by soft factors (i.e. cultural factors, societal norms, etc.). In addition, there is rarely just one isolated enemy; the behaviors and responses of all groups in the region, and the dynamics of the interaction among them composes an important part of the whole picture. The Dynamic Adversarial Gaming Algorithm (DAGA) project aims to provide a wargaming environment for automation of simulating dynamics of geopolitical crisis and eventually be applied to military simulation and training domain, and/or commercial gaming arena. The focus of DAGA is on modeling communities of interest (COIs), where various individuals, groups, and organizations as well as their interactions are captured. The framework should provide a context for COIs to interact with each other and influence others' behaviors. These behaviors must incorporate soft factors by modeling cultural knowledge. We do so by representing cultural variables and their influence on behavior using probabilistic networks. In this paper, we describe our COI modeling, the development of cultural networks, the interaction architecture, and a prototype of DAGA.
Social Impact of Connected Landmark Lighting: A Social Sensing Approach (2020)

The benefits of using light emitting diode (LED) lighting for landmarks extend beyond energy savings to the use of illumination for creating visual identity, placemaking, and increasing tourism. While measuring energy consumption is possible with metering technologies, thereby quantifying savings in energy costs, quantification of the social impact of landmark lighting is not straightforward. Measuring and monitoring social impact metrics is key to stakeholders investing in new connected LED lighting systems or upgrades of conventional lighting in order to realize the benefits of lighting that are beyond energy sustainability. We consider social sensing as an approach to quantifying social impact of landmark lighting. Using lighting at the Empire State Building and Bay Bridge as case studies, social sensing querying and data analytics aspects are presented. A number of practical lessons and technical directions for the use of social sensing in connected landmark lighting are then laid out.
Efficient cross-effect dynamic nuclear polarization without depolarization in high-resolution MAS NMR (2017)

Dynamic nuclear polarization (DNP) has the potential to enhance the sensitivity of magic-angle spinning (MAS) NMR by many orders of magnitude and therefore to revolutionize atomic resolution structural analysis. Currently, the most widely used approach to DNP for studies of chemical, material, and biological systems involves the cross-effect (CE) mechanism, which relies on biradicals as polarizing agents. However, at high magnetic fields (≥5 T), the best biradicals used for CE MAS-DNP are still far from optimal, primarily because of the nuclear depolarization effects they induce. In the presence of bisnitroxide biradicals, magic-angle rotation results in a reverse CE that can deplete the initial proton Boltzmann polarization by more than a factor of 2. In this paper we show that these depolarization losses can be avoided by using a polarizing agent composed of a narrow-line trityl radical tethered to a broad-line TEMPO. Consequently, we show that a biocompatible trityl-nitroxide biradical, TEMTriPol-1, provides the highest MAS NMR sensitivity at ≥10 T, and its relative efficiency increases with the magnetic field strength. We use numerical simulations to explain the absence of depolarization for TEMTriPol-1 and its high efficiency, paving the way for the next generation of polarizing agents for DNP. We demonstrate the superior sensitivity enhancement using TEMTriPol-1 by recording the first solid-state 2D <sup>13</sup>C-<sup>13</sup>C correlation spectrum at natural isotopic abundance at a magnetic field of 18.8 T.
Abstract B06: Repositioning the FDA-approved antiviral drug ribavirin as targeted therapy for nasopharyngeal carcinoma (2020)

Abstract Purpose: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma that is often diagnosed at an advanced stage, leading to poor disease-free and overall survival. Accumulating literature suggests that elevated protein expression of enhancer of zeste homolog 2 (EZH2), eukaryotic initiation factor 4E (eIF4E), and inosine-5’-monophosphate dehydrogenase (IMPDH)—proteins implicated in myriad cancers—correlates with poor prognosis in NPC. These three proteins are modulated by the Food and Drug Administration-approved antiviral drug ribavirin, which has recently been repositioned by our laboratory and others as a promising anticancer agent. Based on this intersection of molecular signature and drug targets, we investigated the potential of ribavirin as a therapeutic agent for NPC. Experimental Design: We assessed antineoplastic efficacy of ribavirin on six human NPC cell lines in vitro using cellular growth assays, flow cytometry, and scratch wound assays. Mechanistic pathways involved were investigated using genomic expression datasets, Western blots, and enzymatic activity assays. The effects of combining ribavirin with radiation were assessed using clonogenic assays and flow cytometry. Finally, we evaluated the effects of ribavirin on tumor growth in vivo using two human cell line-derived xenograft models. Results: Ribavirin significantly decreased NPC cellular proliferation and migratory capacity in addition to promoting cell cycle arrest and cell death. Modulation of the EZH2, Snail, eIF4E, and IMPDH pathways was observed in response to ribavirin treatment. Ribavirin significantly enhanced the cytotoxic effects of radiation therapy in NPC. Most importantly, ribavirin significantly reduced flank tumor growth in two NPC xenograft models. Conclusions: Our work suggests that ribavirin has potent anticancer effects in NPC and could represent a safe and promising addition to current NPC treatment regimens. Citation Format: Sakibul Huq, Joshua Casaos, Michael Peters, Yuanxuan Xia, Andy Ding, Manuel Morales, Noah Gorelick, Riccardo Serra, Tianna Zhao, Wataru Ishida, Alexander Perdomo-Pantoja, Arba Cecia, Chenchen Ji, Ian Suk, David Sidransky, Mariana Brait, Henry Brem, Nicolas Skuli, Betty Tyler. Repositioning the FDA-approved antiviral drug ribavirin as targeted therapy for nasopharyngeal carcinoma [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; 2019 Apr 29-30; Austin, TX. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(12_Suppl_2):Abstract nr B06.
Uprising period and elevation of the Wenyu granitic pluton in the Xiaoqinling District, Central China (2013)

Xiaoqinling District is an important gold-producing area in China. It ranks second to Jiaodong with regard to gold deposits. The uprising period of the Wenyu granitic pluton and the wall-rocks of the deposit, as well as the mineralizing depth and reserved place of gold ore bodies, are significant to ore exploration. Fission-track (FT) analysis of zircons and apatites of granitic rocks from the Wenyu granitic pluton shows that apatite FT (AFT) data modeling indicates a rapid cooling rate of 20°C/Ma from 138 to 120 Ma after emplacement at 138 Ma. Thermal evolution and inversion curves suggest a secondary phase of fast cooling and uprising from 45 to 35 Ma, and 35 Ma, respectively, with a cooling rate of 6.7°C/Ma and a denudation quantity of ∼4.3 km. The last cooling phase took place from <4 Ma, with an average cooling rate of ∼11.3°C/Ma and a denudation amount of 1.3 km. Total exhumation quantity of 5.6 km and uprising elevation of 7.3 km are similar to the estimated results of fluid inclusions from the Dongtongyu and Wenyu gold deposits. The 39Ar/40Ar dating of sericite from the fault planes of the Xunmadao-Xiaohe and Taiyao faults demonstrate two uprising activities of the ore-host metamorphic complex. The Huashan and Wenyu granitic plutons intensively occurred during 77 and 45 Ma, respectively. These data sets are valuable for understanding the uplifting process and for preserving gold ore bodies in the Xiaoqinling area, as well as for further studies on tectonic evolutions of the Taihua Complex and the Qinling-Dabie Orogen.
SMTP Require TLS Option (2019)

The SMTP STARTTLS option, used in negotiating transport-level
encryption of SMTP connections, is not as useful from a security
standpoint as it might be because of its opportunistic nature; message
delivery is, by default, prioritized over security. This document
describes an SMTP service extension, REQUIRETLS, and message header
field, TLS-Required. If the REQUIRETLS option or TLS-Required message
header field is used when sending a message, it asserts a request on
the part of the message sender to override the default negotiation of
TLS, either by requiring that TLS be negotiated when the message is
relayed, or by requesting that recipient-side policy mechanisms such
as MTA-STS and DANE be ignored when relaying a message for which
security is unimportant.
Implementation of atomic layer deposition-based AlON gate dielectrics in AlGaN/GaN MOS structure and its physical and electrical properties (2018)

Alumina incorporating nitrogen (aluminum oxynitride; AlON) for immunity against charge injection was grown on a AlGaN/GaN substrate through the repeated atomic layer deposition (ALD) of AlN layers and in situ oxidation in ozone (O3) ambient under optimized conditions. The nitrogen distribution was uniform in the depth direction, the composition was controllable over a wide range (0.5–32%), and the thickness could be precisely controlled. Physical analysis based on synchrotron radiation X-ray photoelectron spectroscopy (SR-XPS) revealed that harmful intermixing at the insulator/AlGaN interface causing Ga out-diffusion in the gate stack was effectively suppressed by this method. AlON/AlGaN/GaN MOS capacitors were fabricated, and they had excellent electrical properties and immunity against electrical stressing as a result of the improved interface stability.
Phase separation during fast (RIM) poly‐urethane polymerization (1989)

Abstract Phase separation dynamics during a reaction injection molding process of an elastomeric polyurethane was studied via FT‐IR and rheology. 4, 4′ methylenediphenyl isocyanate and 1, 4 butanediol were mixed with 50 wt% of a 2000 molecular weight poly(proplyene oxide)polyol catalyzed by dibutyltin dilaurate. A small reaction injection molding machine was used to impingement mix the chemicals and inject these directly into a Fourier transform infrared spectrometer or into a rheometer. The reaction conversion was followed by the isocyanate absorbance and the development of inter‐urethane hydrogen bonding was related to phase separation dynamics. Isothermal dynamic mechanical modulus build‐up during reaction was monitored by a thin gap parallel plate geometry subjected to small amplitude oscillation. An optimum reaction temperature was found, below which phase separation prematurely cuts off high molecular weight build up. Above this temperature phase separation is too slow and incomplete; modulus values are lower. Increasing catalyst reduces this optimum temperature.
Noise Reduction in Industrial Control Cabinets – The New Industrial Chapter in the Emerald Book (IEEE Standard 1100) (2006)

This paper provides an introduction to the new industrial systems chapter of the Emerald Book. The basic concepts of the high frequency model, noise modes, field coupling, and shielding are explained. These concepts are then applied to the techniques of bonding, segregation and filtering to explain recommended practices for control cabinet design
Compiler Support for Sparse Tensor Computations in MLIR (2022)

Sparse tensors arise in problems in science, engineering, machine learning, and data analytics. Programs that operate on such tensors can exploit sparsity to reduce storage requirements and computational time. Developing and maintaining sparse software by hand, however, is a complex and error-prone task. Therefore, we propose treating sparsity as a property of tensors, not a tedious implementation task, and letting a sparse compiler generate sparse code automatically from a sparsity-agnostic definition of the computation. This paper discusses integrating this idea into MLIR.
High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) RF-DC Ion Mobility Spectrometry (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Bandwidth estimation for adaptive optical systems based on stochastic parallel gradient descent optimization (2004)

Adaptive system bandwidth estimation techniques that can be applied to the adaptive optical systems based on stochastic parallel gradient descent (SPGD) optimizations are described. A useful parameter characterizing temporal dynamics of phase fluctuations resulting from the pupil-plane phase distorting layer moving at a certain velocity (wind velocity) is the Greenwood frequency. The knowledge of the Greenwood frequency and clock frequency of the adaptive control system (first order controller) allows simple estimation of the performance metric Strehl ratio. The numerical analyses indicate that the system performance can be characterized through the ratio of the Greenwood frequency and the system iterative process clock-frequency. A formula that estimates how the degradation of the adaptation performance in SPGD based compensators are derived and analyzed numerically. The bandwidth estimation for SPGD control systems with different resolution and decoupled SPGD (D-SPGD) control system is detailed.
Fluorescence polarization-based detection of cancer-related mutations using target-initiated rolling circle amplification (2019)

We devised a new method to detect cancer-related mutations based on target-initiated rolling circle amplification in combination with fluorescence polarization. We then applied this method to identify the presence of KRAS G13D and G12D, two of the most frequent mutations found in colorectal cancer patients, demonstrating high sensitivity and specificity.
Reliable force-sensorless contact detection method for ball screw drive cartesian robot (2013)

This paper proposes a reliable method for contact detection in ball screw drive industrial robots. Moreover, the proposed method assumes a type of robot has no force sensor for contact detection. Reaction force observer estimates the external force without such a sensor. To succeed, however, the method requires correct modeling of the robot dynamics for obtaining precise estimation of force. A ball screw has a characteristic of complex nonlinear friction, which includes viscous friction, coulomb friction, rolling friction, etc. The friction model therefore includes some error due to variation its parameters. The contact detection must be correct even if the force estimation includes a degree of error. In this method, a jerk signal indicate the impact of contact on sensorless force estimation, even if the robot model has some identification error. In addition, the dynamic threshold is set at a level that facilitates precise contact detection by comparison with the jerk signal from the robot's motion. The validity of the proposed method is confirmed in experimental studies performed on an actual industrial robot, whose operation involves a ball screw.