gebhart/patrepeval huggingface dataset:
Electrodeposition of portable, metal nanowire arrays (2002)

Parallel arrays of long (&gt; 500 m), dimensionally uniform nanowires composed of molybdenum, copper, nickel, gold, and palladium were electrodeposited. Nanowires with diameters in the range from 15 nm to 750 nm were obtained by electrodepositing these metals, or metal oxides, selectively at the step edges present on the surface of a highly oriented pyrolytic graphite electrode. Depending on the metal, either of two methods were used to carry out electrochemical step edge decoration (ESED): Nanowires of Ni, Cu or Mo were prepared by electrodepositing nanowires of a conductive metal oxide such as NiO, Cu<sub>2</sub>O, or MoO<sub>2</sub>. Nanowires of the parent metal were then obtained by reducing the metal oxide nanowires in hydrogen at elevated temperature. Nanowires composed of noble metals and some coinage metal can be obtained by direct electrodeposition of the metal at step edges. Direct electrodeposition involved the application of three voltage pulses in succession: An oxidizing "activation" pulse, a large amplitude, reducing "nucleation" pulse, and a small amplitude reducing "growth" pulse. These nanowires arrays were "portable": After embedding the nanowires in a polymer film, arrays of nanowires could be lifted off the graphite surface thereby facilitating the incorporation of these arrays in devices such as sensors.
On Optimal Watermarking Schemes in Uncertain Gaussian Channels (2007)

This paper describes the analytical derivation of a new watermarking algorithm satisfying optimality properties when the distortion of the watermarked signal is caused by a Gaussian process. We also extend previous work under the same assumptions and obtain more general solutions.
Performance of Iterative Digital Self-Interference Canceler with Alternating Estimate Subtraction for OFDM Using Full Duplex (2019)

In full duplex (FD), which improves the system capacity (or cell throughput) and reduces the transmission delay (or latency) through simultaneous transmission and reception in the same frequency band, self-interference (SI) from the transmitter should be suppressed using antenna isolation, an analog SI canceler, and digital SI canceler (DSIC) to a level such that the data or control channel satisfies the required block error rate (BLER). This paper proposes a structure of iterative DSIC with alternating estimate subtraction (AES-IDSIC) for orthogonal frequency division multiplexing (OFDM) using FD. We first present the required SI suppression level considering SI, quantization noise of an analog-to-digital converter, and nonlinear distortion of a power amplifier and RF receiver circuit for a direct conversion transceiver using FD. Then, we propose an AES-IDSIC structure that iterates the generation of the SI estimate, the downlink symbol estimate, and then alternately removes one of the estimates from the received signal in the downlink including SI. We investigate the average BLER performance of the AES-IDSIC for OFDM using FD in a multipath fading channel based on link-level simulations under the constraint that the derived required signal-to-SI ratio must be satisfied.
Crowdsourcing Access Network Spectrum Allocation Using Smartphones (2014)

The hundreds of millions of deployed smartphones provide an unprecedented opportunity to collect data to monitor, debug, and continuously adapt wireless networks to improve performance. In contrast with previous mobile devices, such as laptops, smartphones are always on but mostly idle, making them available to perform measurements that help other nearby active devices make better use of available network resources. We present the design of PocketSniffer, a system delivering wireless measurements from smartphones both to network administrators for monitoring and debugging purposes and to algorithms performing realtime network adaptation. By collecting data from smartphones, PocketSniffer supports novel adaptation algorithms designed around common deployment scenarios involving both cooperative and self-interested clients and networks. We present preliminary results from a prototype and discuss challenges to realizing this vision.
Chemical and Microbial Characterization of Citrus Oil‐Mill Effluent (1986)

ABSTRACT The aqueous discharge produced by centrifuges in a citrus peel‐oil recovery system was chemically and microbially characterized. The discharge contained 3.82 °Brix, 2.60% sugars, 0.28% recoverable oil, and a BOD of 22,600 mg/L. Minerals in ppm included K(604), Na(248), Fe(185), and Ca(105). Citric and malic were the major acids, 0.78 and 0.31 mg/mL, respectively. Concentration ratios of sugars were 3.6:1.7:1 for sucrose:glucose:fructose. Aerobic plate counts were 7.3 × 10 7 colony forming units (cfu) per mL while indogenous yeast and mold counts were 1.8 × 10 5 cfu/mL. Four yeasts isolated from the effluent were presumptively identified as members of the genus Saccharomyces.
Supplementary Table 2 from Dysfunctional Microvasculature as a Consequence of <i>Shb</i> Gene Inactivation Causes Impaired Tumor Growth (2023)

Supplementary Table 2 from Dysfunctional Microvasculature as a Consequence of &lt;i&gt;Shb&lt;/i&gt; Gene Inactivation Causes Impaired Tumor Growth
Deterministic High-yield Creation of Nitrogen Vacancy Centers in Diamond Photonic Crystal Cavities and Photonic Elements (2015)

We demonstrate the high-yield creation of nitrogen-vacancy centers in the mode-maxima of a variety of functional photonic elements with less than 30nm precision. We create 1.1 NVs per photonic-crystal-cavity and show strong Purcell enhancement.
Data from Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes (2023)

&lt;div&gt;Abstract&lt;p&gt;Tumor-associated macrophages (TAM) form a major component of the tumor stroma. However, important concepts such as TAM heterogeneity and the nature of the monocytic TAM precursors remain speculative. Here, we show for the first time that mouse mammary tumors contained functionally distinct subsets of TAMs and provide markers for their identification. Furthermore, in search of the TAM progenitors, we show that the tumor-monocyte pool almost exclusively consisted of Ly6C&lt;sup&gt;hi&lt;/sup&gt;CX&lt;sub&gt;3&lt;/sub&gt;CR1&lt;sup&gt;low&lt;/sup&gt; monocytes, which continuously seeded tumors and renewed all nonproliferating TAM subsets. Interestingly, gene and protein profiling indicated that distinct TAM populations differed at the molecular level and could be classified based on the classic (M1) versus alternative (M2) macrophage activation paradigm. Importantly, the more M2-like TAMs were enriched in hypoxic tumor areas, had a superior proangiogenic activity &lt;i&gt;in vivo&lt;/i&gt;, and increased in numbers as tumors progressed. Finally, it was shown that the TAM subsets were poor antigen presenters, but could suppress T-cell activation, albeit by using different suppressive mechanisms. Together, our data help to unravel the complexities of the tumor-infiltrating myeloid cell compartment and provide a rationale for targeting specialized TAM subsets, thereby optimally “re-educating” the TAM compartment. Cancer Res; 70(14); 5728–39. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
A MEMS-based approach to detection of single nucleotide polymorphisms for genetic disorder diagnosis (2012)

This paper presents an integrated, MEMS-based approach to the detection of single nucleotide polymorphisms (SNPs). This SNP detection approach aims to eliminate complicated fluidic control operations by using a single-chamber microfluidic device, which incorporates polymerase chain reaction (PCR) and single base extension (SBE) on microbeads. Experimental results demonstrate that the device is capable of performing bead-based PCR, chemical elution, thermal elution, bead-based SBE, and on-chip desalting, which together potentially allow rapid, simple, accurate, multiplexed and highly efficient detection of SNPs.
Path Diversity with Fractional Delay Transmission for Fractional Sampling-MIMO-OFDM System (2010)

Through fractional sampling (FS) it is possible to separate multipath components and achieve path diversity. However, if no path component whose delay corresponds to the sampling point, FS cannot obtain diversity gain. In this paper, a novel scheme to improve the performance with FS over a sparse multipath channel is proposed. The proposed scheme uses multiple transmit antennas and sends multiple signals with fractional delays. The performance improvement with the proposed scheme is confirmed through computer simulation. It is shown that the proposed scheme increases the capacity of a MIMO-OFDM system by a factor of 1.5 to 2 and improves the BER performance on the sparse multipath channels.
Experience Integrating a New Compiler and a New Garbage Collector Into Rotor. (2004)

Microsoft's Rotor is a shared-source CLI implementation intended for use as a research platform. It is particularly attractive for research because of its complete implementation and extensive libraries, and because its modular design allows different implementations of certain components such as just-in-time compilers (JITs). Our group has independently developed our own high-performance JIT and garbage collector (GC) and wanted to take advantage of Rotor to experiment with these components in a CLI environment. In this paper, we describe our experience integrating these components into Rotor and evaluate the flexibility of Rotor's design toward this goal. We found it easier to integrate our JIT than our GC because Rotor has a well-defined interface for the former but not the latter. However, our JIT integration still required significant changes to both Rotor and our JIT. For example, we modified Rotor to support multiple JITs. We also added support for a second JIT manager in Rotor, and implemented a new code manager compatible with our JIT. We had to change our JIT compiler to support Rotor's calling conventions, helper functions, and exception model. Our GC integration was complicated by the many places in Rotor where components make assumptions about how its garbage collector is implemented, as well as Rotor's lack of a well-defined GC interface. We also had to reconcile the different assumptions made by Rotor and our garbage collector about the layout of objects, virtual-method tables, and thread structures.
Accumulation of PEG-liposomes in the Inflamed Colon of Rats: Potential for Therapeutic and Diagnostic Targeting of Inflammatory Bowel Diseases (2002)

Therapeutic intervention in inflammatory bowel diseases (IBDs) is often associated with severe toxicity related to the nonspecific and ubiquitous interaction of drugs with the organs and tissues. In order to prevent side effects from aggressive and prolonged treatment with glucocorticoids and immunosuppressive agents, preferential accumulation of these potent drugs in diseased tissue is desired. In this work, we report that liposomes show a remarkable tendency to accumulate in inflamed colon of rats with experimental colitis. The disposition of liposomes was monitored by labeling them with Tc-99m followed by gamma camera imaging, and determining biodistribution of radioactivity in various organs. The images showed distinct accumulation of radioactivity in the colon of rats with colitis, while the abdomen of normal rats was conspicuously free of any visible radioactivity. Although images acquired 4 h after Tc-99m-liposome injection were clear enough for diagnostic indication, the real potential of liposomes for drug delivery was evident in 24 h images where the major organs of liposome accumulation were dwarfed by intense colon activity in animals with colitis. On necropsy, 13.5% +/- 5.48 of the activity accumulated in the inflamed colon as compared to only 0.1% in the normal colon, giving a target-to-nontarget ratio of 135. The blood borne radioactivity was 9% +/- 2.12 (colitis) and 25.7% +/- 4.27 (normal), indicating that the decrease in circulating liposomes is associated with an increase in liposome accumulation in the inflammatory site. The other two major organs that accumulated liposomes were spleen (10.7% normal vs. 11% colitis) and liver (8% normal vs. 10.1% colitis). In conclusion, this study demonstrates the innate propensity of liposomes to accumulate in the sites of inflammation and potential of liposomes loaded with therapeutic drugs or diagnostic agents for targeting colitis.
Multivalvular surgery for infective endocarditis (1999)

The short and the long-term results of our experience with 25 consecutive patients who underwent multivalvular surgery for infective endocarditis are analysed. Preoperatively, 20/25 (80%) patients were in New York Heart Association (NYHA) stage III or IV, and 2/25 (8%) patients were in cardiogenic shock. All the diseased valves were replaced with mechanical bileaflet prosthesis except seven mitral valves and one tricuspid valve, which could be repaired. Major postoperative complications occurred in 3/25 (12%) patients: a fatal cerebral haemorrhage, a reversible cerebellar syndrome and an intractable heart failure, which required transplantation. During a mean follow-up of 4.7 years (range 6 months to 16.8 years), 7/25 (28%) patients suffered from valve-related complications: five bleedings (one died), one embolic event and one prosthetic valve thrombosis. The actuarial freedom of valve-related event at 10 years was 61.8 +/- 12.4%. There was no prosthetic endocarditis. At follow-up, 20/21 (95%) survivors were in NYHA stage I or II. Long-term outcome in our patient population operated on for multivalvular endocarditis, is satisfactory with no recurrent infection and excellent functional results.
Glass Frit Wafer Bonding for Encapsulating Monolithic Integrated CMOS-MEMS Devices (2018)

CMOS-MEMS integration is getting a more and more important topic with growing expectations and requirements on the function and performance of micro sensors [1]. The integration of ASICs and memories to MEMS sensor structures allows by calibration the compensation of side effects (temperature influences, stress influences,...) and manufacturing tolerances. Thus, very accurate sensors, at acceptable cost structures for high volume applications become feasible. These high volume applications are often for mobile devices or other use cases where the form factor is important as well – here the wafer level integration and the wafer level packaging (wafer bonding) also offer many opportunities.
The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements (2016)

The computational properties of the human brain arise from an intricate interplay between billions of neurons connected in complex networks. However, our ability to study these networks in healthy human brain is limited by the necessity to use non-invasive technologies. This is in contrast to animal models where a rich, detailed view of cellular-level brain function with cell-type-specific molecular identity has become available due to recent advances in microscopic optical imaging and genetics. Thus, a central challenge facing neuroscience today is leveraging these mechanistic insights from animal studies to accurately draw physiological inferences from non-invasive signals in humans. On the essential path towards this goal is the development of a detailed 'bottom-up' forward model bridging neuronal activity at the level of cell-type-specific populations to non-invasive imaging signals. The general idea is that specific neuronal cell types have identifiable signatures in the way they drive changes in cerebral blood flow, cerebral metabolic rate of O2 (measurable with quantitative functional Magnetic Resonance Imaging), and electrical currents/potentials (measurable with magneto/electroencephalography). This forward model would then provide the 'ground truth' for the development of new tools for tackling the inverse problem-estimation of neuronal activity from multimodal non-invasive imaging data.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.
On the Promise and Pitfalls of Optimizing Embodied Carbon (2023)

To halt further climate change, computing, along with the rest of society, must reduce, and eventually eliminate, its carbon emissions. Recently, many researchers have focused on estimating and optimizing computing's embodied carbon, i.e., from manufacturing computing infrastructure, in addition to its operational carbon, i.e., from executing computations, primarily because the former is much larger than the latter but has received less research attention. Focusing attention on embodied carbon is important because it can incentivize i) operators to increase their infrastructure's efficiency and lifetime and ii) downstream suppliers to reduce their own operational carbon, which represents upstream companies' embodied carbon. Yet, as we discuss, focusing attention on embodied carbon may also introduce harmful incentives, e.g., by significantly overstating real carbon reductions and complicating the incentives for directly optimizing operational carbon. This position paper's purpose is to mitigate such harmful incentives by highlighting both the promise and potential pitfalls of optimizing embodied carbon.
Using Modelling to Disentangle the Relative Contributions of Zoonotic and Anthroponotic Transmission: The Case of Lassa Fever (2015)

This work explains the discrepancy between the sizes of reported LF outbreaks and a clinical perception that human-to-human transmission is low. Future assessment of risks of LF and infection control guidelines should take into account the potentially large impact of super-spreaders in human-to-human transmission. Our work highlights several neglected topics in LF research, the occurrence and nature of super-spreading events and aspects of social behavior in transmission and detection.
Identification and characterization of arginine vasopressin-like substances in the rat testis. (1985)

We have previously demonstrated the suppression of Leydig cell steroidogenesis by arginine vasopressin (AVP) in vitro. Since the circulating level of AVP is too low to mediate a testicular action of this peptide, we have conducted studies to identify testicular AVP-like substances. The supernatant of homogenized, acid-extracted rat testes was found to contain AVP immunoreactivity which showed parallelism with synthetic AVP in a specific radioimmunoassay for AVP. Chromatography of this extract on a Sephadex G-25 column produced three peaks of AVP immunoreactivity. The largest peak eluted close to the column void volume, a second smaller peak eluted at the total column volume, while a third peak co-eluted with synthetic AVP. Following acetone precipitation, ether extraction, and octadecylsilica (C18) adsorption chromatography of the acid extract, the third peak of AVP immunoreactivity (about 600 pg/testis) was fully retained by C18 chromatography and showed parallelism with synthetic AVP in both radioimmuno- and radioreceptor assays. This substance also co-migrated with synthetic AVP on both Sephadex G-25 and reverse-phase thin layer chromatography (RPTLC). The second peak was only partially retained by C18 adsorption chromatography, dilution curves were not parallel with synthetic AVP in radioimmuno- or radioreceptor assay, and this material failed to co-migrate with synthetic AVP on Sephadex G-25 and RPTLC. The first peak of apparent AVP immunoreactivity was associated with an enzyme(s) that degraded labeled AVP. This enzymatic activity, as well as the immunoreactivity, could be eliminated by heating the extract to 90 degrees C. These results demonstrate, by a number of independent criteria, that rat testes contain a substance which behaves like authentic AVP. Due to its high concentration, the AVP-like peptide may be synthesized or concentrated by testis cells. In addition, testis tissue contains enzymatic activity which degrades AVP and could represent a site of regulation of AVP action. Coupled with the previously demonstrated testis action of AVP, these results suggest a paracrine or autocrine role of the neurohypophysial hormone at the testis level.
Reactions towards enediyne heterocycles and nitroimidazoles incorporating alkynes (1999)

In this thesis it was hypothesized that the incorporation of a 2nitroimidazole (NIM) into an enedlyne system or its functionalization with a glutathione (GSH) depleting moiew may result in a new group of more effective hypoxic cell selective radiosensitizer/chemosensitizer antitumor agents.Generation of NIM incorporating enediyne proved to be diEcult and unsuccessfd.Initially, the synthetic outline was to attach 2 allrynes to 43diiodo-1-(methoxymethy1)-2-nitrormidazol (1,NIM) followed by a ring closure to obtain the cyclic NIM incorporating enediyne compound.However, due to the high reactivity of 1-NIM at the 5 position only monoalkyne M M was produced.far away.First and foremost my wife, Toufan, for her great love and patient support before and during the preparation of this thesis.My Clan, Mamoo,
The immune response of the lacrimal gland to antigenic exposure (1987)

This study probed the influence of antigenic exposure on the immunological response of the lacrimal gland. We utilized the germfree rat as a model system to monitor tissue and tear immunoglobulin changes following transfer of these animals into an antigen-laden, conventional environment. The number of IgA- and IgM-containing cells in the lacrimal glands of germfree rats was 5 to 8 fold less than that of conventional controls. This reduced immunological expression in germfree animals also extended to tear IgA levels, which were significantly decreased. No effect of germfree conditions was found on the tear content of secretory component (SC). Transfer of rats from a germfree to a conventional environment resulted in a significant increase in the number of IgA- and IgM-containing cells in the lacrimal gland. By four weeks after 'conventionalization', the number of Ig-containing cells in lacrimal tissue was similar in both ex-germfree and conventional rats. In addition, 'conventionalization' led to a significant increase in the tear content of IgA: within four weeks following exposure to a conventional environment, tear IgA levels in ex-germfree rats were equivalent to those of age-matched, conventional controls. Overall, our results demonstrate that the secretory immune system of the lacrimal gland reacts to antigenic challenge with an increased immunological response.
Measurements of jet charge with dijet events in pp collisions at s = 8 $$ \sqrt{s}=8 $$ TeV (2017)

Jet charge is an estimator of the electric charge of a quark, antiquark, or gluon initiating a jet. It is based on the momentum-weighted sum of the electric charges of the jet constituents. Measurements of three charge observables of the leading jet in transverse momentum p T are performed with dijet events. The analysis is carried out with data collected by the CMS experiment at the CERN LHC in proton-proton collisions at s = 8 TeV corresponding to an integrated luminosity of 19.7 fb -1 . The results are presented as a function of the p T of the leading jet and compared to predictions from leadingand next-to-leading-order event generators combined with parton showers. Measured jet charge distributions, unfolded for detector effects, are reported, which expand on previous measurements of the jet charge average and standard deviation in pp collisions.