gebhart/patrepeval huggingface dataset:
Direct observation of sulfur coordination in bean plastocyanin by x-ray photoelectron spectroscopy (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect observation of sulfur coordination in bean plastocyanin by x-ray photoelectron spectroscopyEdward I. Solomon, Paula J. Clendening, Harry B. Gray, and F. J. GrunthanerCite this: J. Am. Chem. Soc. 1975, 97, 13, 3878–3879Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ja00846a087https://doi.org/10.1021/ja00846a087research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wood monitoring using MEMS acoustic sensor (2016)

This paper presents an approach for wood monitoring using a piezoresistive acoustic sensor. The sensor utilizes the structure of liquid-on-beam, which is highly sensitive and able to measure vibration in a wide frequency range. Surface of the sensor is covered with PDMS (Polydimethylsiloxane), whose acoustic impedance is matched with that of xylem. Experiments demonstrate that the sensor can monitor the crack generation on woods and the frequency response changes according to the moisture content.
Enrichment of Genistein in Soy Protein Concentrate with Hydrocolloids and β‐glucosidase (2000)

ABSTRACT: The effects of hydrocolloid (propylene glycol alginate, K‐carrageenan, citrus pectin, and xanthan gum) additions in soy protein concentrate (SPC) preparation on genistin and genistein retentions were investigated. Additions of xanthan, alginate, pectin, and carrageenan in SPC prepared with the acid leach method gave 0.711, 0.760, 0.792, and 0.825 mg/g genistein, respectively, whereas control SPC prepared without hydrocolloid gave 0.721 mg/g genistein. SPC prepared under optimum conditions for (β‐glucosidase hydrolytic activity with xanthan, alginate, carrageenan, and pectin had 0.943, 0.975, 1.015, and 1.132 mg/g genistein, respectively, compared to genistein in control SPC (0.845 mg/g) under the optimum conditions. Combined (β‐glucosidase and pectin treatment in SPC preparation resulted in high genistein SPC (1.551 mg/g).
Rethinking ASIC design with next generation lithography and process integration (2013)

Given the deployment delays for EUV, several next generation lithography (NGL) options are being actively researched. Several cost-effective NGL solutions, such as self-aligned double patterning through sidewall image transfer (SIT) and directed self-assembly (DSA), in conjunction with process integration challenges, mandate grating-like pattern design. As part of the GRATEdd project, we have evaluated the design cost of grating-based design for ASICs (application specific ICs). Based on our observations we have engineered fundamental changes to the primary ASIC design components to make scaling affordable and useful in deeply scaled sub-20 nm technologies: unidirectional-M1 based standard cells, application-specific smart SRAM synthesis, and statistical and self-healing analog design.
ChemInform Abstract: Multiple Bonds Between Main Group Elements and Transition Metals. Part 23. Multiple Bonds Between "Naked" Lead and Transition Metals ‐ the First Example. (1986)

Abstract Der aus (Ia) durch Bestrahlung in THF leicht zugängliche, substitutionslabile Lösungsmittelkomplex (Ib) setzt sich mit PbCl 2 zu dem Produkt (II) um, das in Lösung licht‐ und sauerstoffempfindlich, an Luft aber bis ca. 130°C kurzzeitig haltbar ist.
3D Dynamic Spatiotemporal Atlas of the Vocal Tract during Consonant–Vowel Production from 2D Real Time MRI (2022)

In this work, we address the problem of creating a 3D dynamic atlas of the vocal tract that captures the dynamics of the articulators in all three dimensions in order to create a global speaker model independent of speaker-specific characteristics. The core steps of the proposed method are the temporal alignment of the real-time MR images acquired in several sagittal planes and their combination with adaptive kernel regression. As a preprocessing step, a reference space was created to be used in order to remove anatomical information of the speakers and keep only the variability in speech production for the construction of the atlas. The adaptive kernel regression makes the choice of atlas time points independently of the time points of the frames that are used as an input for the construction. The evaluation of this atlas construction method was made by mapping two new speakers to the atlas and by checking how similar the resulting mapped images are. The use of the atlas helps in reducing subject variability. The results show that the use of the proposed atlas can capture the dynamic behavior of the articulators and is able to generalize the speech production process by creating a universal-speaker reference space.
Scleral Patch Graft Melt After Tube Shunt Surgery: Grading and Identification of Risk Factors (2018)

SG melts gradually after tube shunt surgery with the most dramatic melt occurring after 12 months postoperatively. This simple and consistent SG grading scale has high interrater agreement and can be may be used to assess and follow graft health over time.
Biosynthesis of a Site-Specific DNA Cleaving Protein (2008)

An E. coli catabolite activator protein (CAP) has been converted into a sequence-specific DNA cleaving protein by genetically introducing (2,2'-bipyridin-5-yl)alanine (Bpy-Ala) into the protein. The mutant CAP (CAP-K26Bpy-Ala) showed comparable binding affinity to CAP-WT for the consensus operator sequence. In the presence of Cu(II) and 3-mercaptopropionic acid, CAP-K26Bpy-Ala cleaves double-stranded DNA with high sequence specificity. This method should provide a useful tool for mapping the molecular details of protein-nucleic acid interactions.
Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus. (1998)

(a) skeletal muscle PPARgamma1 expression does not differ between normal and diabetic subjects, and is not induced by short-term hyperinsulinemia; (b) skeletal muscle PPARgamma1 expression was higher in subjects whose percent body fat exceeded 25%, and this may be a compensatory phenomenon in an attempt to maintain normal insulin sensitivity.
Robust speech recognition based on structured modeling, irrelevant variability normalization and unsupervised online adaptation (2009)

We present a new approach to robust speech recognition based on structured modeling, irrelevant variability normalization (IVN) and unsupervised online adaptation (OLA). In offline training stage, a set of generic HMMs for basic speech units relevant to phonetic classification is trained along with several sets of feature transforms with different degrees of freedom by using a maximum likelihood (ML) IVN-based training strategy. In recognition stage, after a first-pass recognition, the most appropriate set of feature transforms is identified and adapted under ML criterion by using the unknown utterance itself, which is recognized again to achieve better performance by using the adapted feature transforms and the pre-trained generic HMMs. The effectiveness of the proposed approach is confirmed by evaluation experiments on Finnish Aurora3 database.
Nanoscale investigation of a radial p–n junction in self-catalyzed GaAs nanowires grown on Si (111) (2018)

One obstacle for the development of nanowire (NW) solar cells is the challenge to assess and control their nanoscale electrical properties. In this work a top-cell made of p-n GaAs core/shell NWs grown on a Si(111) substrate by Molecular Beam Epitaxy (MBE) is investigated by high resolution charge collection microscopy. Electron Beam Induced Current (EBIC) analyses of single NWs have validated the formation of a homogeneous radial p-n junction over the entire length of the NWs. The radial geometry leads to an increase of the junction area by 38 times with respect to the NW footprint. The interface between the NWs and the Si(111) substrate does not show any electrical loss, which would have led to a decrease of the EBIC signal. Single NW I-V characteristics present a diodic behavior. A model of the radial junction single NW is proposed and the electrical parameters are estimated by numerical fitting of the I-Vs and of the EBIC map. Solar cells based on NW arrays were fabricated and analyzed by EBIC microscopy, which evidenced the presence of a Schottky barrier at the NW/ITO top contact. Improvement of the top contact quality is achieved by thermal annealing at 400 °C, which strongly reduces the parasitic Schottky barrier.
Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis (2020)

To date, no systematic analyses are available assessing concordance of molecular classifications between primary tumors (PT) and matched liver metastases (LM) of metastatic colorectal cancer (mCRC). We investigated concordance between PT and LM for four clinically relevant CRC gene signatures. Twenty-seven fresh and 55 formalin-fixed paraffin-embedded pairs of PT and synchronous LM of untreated mCRC patients were retrospectively collected and classified according to the MSI-like, BRAF-like, TGFB activated-like and the Consensus Molecular Subtypes (CMS) classification. We investigated classification concordance between PT and LM and association of TGFBa-like and CMS classification with overall survival. Fifty-one successfully profiled matched pairs were used for analyses. PT and matched LM were highly concordant in terms of BRAF-like and MSI-like signatures, (90.2% and 98% concordance, respectively). In contrast, 40% to 70% of PT that were classified as mesenchymal-like, based on the CMS and the TGFBa-like signature, respectively, lost this phenotype in their matched LM (60.8% and 76.5% concordance, respectively). This molecular switch was independent of the microenvironment composition. In addition, the significant change in subtypes was observed also by using methods developed to detect cancer cell-intrinsic subtypes. More importantly, the molecular switch did not influence the survival. PT classified as mesenchymal had worse survival as compared to nonmesenchymal PT (CMS4 vs CMS2, hazard ratio [HR] = 5.2, 95% CI = 1.5-18.5, P = .0048; TGFBa-like vs TGFBi-like, HR = 2.5, 95% CI = 1.1-5.6, P = .028). The same was not true for LM. Our study highlights that the origin of the tissue may have major consequences for precision medicine in mCRC.
Analysis of Adenovirus -Vectored Foot-and-Mouth Disease Virus Transgene Expression in Bovine Kidney Cells by Confocal, Electron, and Immuno-Electron Microscopy (2011)

Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Termschema und Energiebänder (2011)

ZusammenfassungAls Quelle von elektromagnetischen Wellen im sichtbaren Bereich haben wir im 2. Kapitel Vorgänge in Atomhüllen identifiziert, deshalb folgt nun ein kleiner Ausflug in die Atomphysik. Da Atome zu klein sind, um sie direkt zu beobachten, wurden die wesentlichen Erkenntnisse über den Bau der Atome aus spektroskopischen Untersuchungen und aus Streuexperimenten gewonnen.
Influence of morphology and rheology on the production characteristics of the basidiomyceteCyathus striatus (1998)

The influence of the pellet morphology of the basidiomycete Cyathus striatus on the production of the antibiotics striatals A, B, and C was investigated. The main operating parameters in fermenters of different sizes were the tip speed and the volumetric power input. Different methods were developed for quantification of morphological characteristics. The apparent viscosity of the suspension was measured with a cylinder rheometer. Sediment density was measured with a sedimentation apparatus. Particle size distributions were recorded with an image analysis system. By means of the presented measuring methods, morphological characteristics could be determined and enabled an early assessment of the fermentation course and the antibiotics production. During the exponential growth phase of the fungus the relative sediment height correlated with the biomass concentration. The pellet morphology at this stage influenced the later production of striatals. The yield of the striatals was markedly influenced by pellet size and sediment density. Since these morphological characteristics determine the rheological properties of the culture the measurement of the apparent viscosity of the culture in the production phase allowed predictions of the production yield.
Topical Developments in High‐Field Dynamic Nuclear Polarization (2014)

We report our recent efforts directed at improving high-field DNP experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε = 25 to 82 that demonstrate the impact of molecular structure on performance. We directly polarized low-gamma nuclei including <sup>13</sup>C, <sup>2</sup>H, and <sup>17</sup>O using trityl via the cross effect. We discuss a variety of sample preparation techniques for DNP with emphasis on the benefit of methods that do not use a glass-forming cryoprotecting matrix. Lastly, we describe a corrugated waveguide for use in a 700 MHz / 460 GHz DNP system that improves microwave delivery and increases enhancements up to 50%.
High-pressure cell for simultaneous small-angle x-ray scattering and laser light scattering measurements (2001)

A cell for in situ observation of self-assembled nanostructured materials in high-pressure fluids, including supercritical carbon dioxide, has been constructed and tested. The compact cell can be used for simultaneous small-angle x-ray scattering, laser light scattering, visual observation, and some other types of spectroscopic measurements. The light scattering plane is normal to the x-ray scattering plane with the optical axis and the x-ray axis being perpendicular to each other. The scattering is detected at the intersection of the light and x-ray beams, and thus one effectively probes the same scattering volume. Some preliminary experimental results for the micellar self-assembly of a fluorinated block copolymer in supercritical carbon dioxide are presented.
Biochemical Changes Induced in Liver and Serum of Aflatoxin B1‐Treated Male Wistar Rats: Preventive Effect of Picroliv (2001)

Administration of aflatoxin B1 to rats (2 mg/kg intraperitoneally) caused significant increase in the activities of gamma-glutamyl transpeptidase, 5'-nucleotidase, acid phosphatase, acid ribonuclease as well as content of lipid peroxides in liver after six weeks. However, the activities of succinate dehydrogenase, glucose-6-phosphatase, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase and glutathione reductase in liver were decreased. The levels of glycogen and reduced glutathione were also decreased. There were significant elevations in the levels of serum transaminases, phosphatases (acid and alkaline), dehydrogenases (sorbitol, lactate and glutamate) and bilirubin following aflatoxin B1 administration. Picroliv (25 mg/kg/day orally for six weeks), an iridoid glycoside isolated from the roots and rhizomes of Picrorhiza kurroa, significantly prevented the biochemical changes induced by aflatoxin B1.
Meta‐analysis of clinical trials as a scientific discipline. II: Replicate variability and comparison of studies that agree and disagree (1987)

The replicate variability of meta-analyses of controlled clinical trials has been assessed as a measure of scientific precision. 46 of 91 known meta-analysis papers were divided into 20 cohorts of studies of the same therapies. Ten cohorts contained meta-analyses with different statistical conclusions; 14 contained differing clinical conclusions with a wider spread than the statistically differing studies. Possible causes of variability, such as different trials included, different policies regarding the inclusion of non-randomized and unpublished trials, and different statistical methodologies, were not obvious causes of differing conclusions. Further work in this area should include multivariate analyses in order to explore possible interactions in the factors accounting for the variability found in replicate meta-analyses.
Reassessing the Host Defense Peptide Landscape (2019)

Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (AMPs) these additional roles have prompted a shift in terminology to use the broader term host defense peptides (HDPs) to capture the multi-functional nature of these molecules. In this review, we critically examined the role of AMPs and HDPs in infectious diseases and inflammation. It is generally accepted that HDPs are multi-faceted mediators of a wide range of biological processes, with individual activities dependent on their polypeptide sequence. In this context, we explore the concept of chemical space as it applies to HDPs and hypothesize that the various functions and activities of this class of molecule exist on independent but overlapping activity landscapes. Finally, we outline several emerging functions and roles of HDPs and highlight how an improved understanding of these processes can potentially be leveraged to more fully realize the therapeutic promise of HDPs.
Diffusivities of Dialkyl Phthalates in Plasticized Poly(vinyl butyral): Impact on Binder Thermolysis (1990)

Hot‐stage/Fourier transform infrared microspectroscopy (FTIR‐M) was used to determine the diffusivities of a series of dialkyl phthalates in poly(vinyl butyral) (PVB) spin‐coated films. The diffusivities ranged from 10 −12 to 10 −10 cm 2 /s for the isotherms investigated (60° to 150°C). In their respective temperature regimes, dimethyl phthalate and diethyl phthalate exhibited nonlinear diffusion behavior, while dibutyl phthalate (DBP) and dioctyl phthalate (DOP) exhibited Fickian behavior in PVB. The activation energies for DBP and DOP diffusion in the PVB‐based films were calculated to be 76.3 and 114.7 kJ/mol, respectively. The diffusitivity of DBP was used to compare the relative importance of diffusion and capillary migration in the thermolysis of PVB‐DBP binders from ceramic greenware. Comparison of the calculated DBP loss due to diffusion alone could not account for the observed removal rates. A characteristic diffusion length is calculated from the experimental observations.
Phase I report from a multicenter trial of perifosine (PERI) + sunitinib (SUT) in patients with advanced cancers including renal cell carcinoma (RCC) (2008)

14565 Background: PERI is an oral alkylphosphocholine that affects multiple signaling pathways, most importantly Akt, and is active in multiple tumor types including sarcoma and RCC. In a phase II trial, 6/9 (66%) RCC patients (pts) derived clinical benefit from PERI: 3 PR’s, 3 SD ≥ 6 mo’s (ASCO 2007 Abstract 15622). Pre-clinical data suggests the combination of PERI with other signal transduction inhibitors results in significantly more apoptosis. This potential synergism along with encouraging RCC results with both PERI and suninitib (SUT), led to a phase 1 trial to determine the MTD combining PERI with SUT. Methods: The trial was designed for 4 cohorts of 3 - 6 pts. The PERI dose was escalated from 50mg qd to 50mg tid and SUT from 25mg to 50mg qd for 4 weeks out of 6. NCI CTCAE v3.0 was used for toxicity assessment; DLT was defined as any grade (G) 3 non-hematologic toxicity or G4 hematologic toxicity. The MTD is the dose cohort below that in which 2 DLT’s are observed. Response assessed by RECIST criteria was a secondary endpoint. Results: 14 pts (8 m / 6 f, median age 62 y, range 28 - 81) had been enrolled by 12/31/07. Disease type was as follows: RCC (3), Sarcoma (3), Other (8). 13/14 pts are evaluable for toxicity with most common related AE’s as follows: One DLT has been reported in cohort 4. 6 pts are evaluable for response with best response to PERI + SUT after ≥ 2 cycles as follows: PR - 1 pt, SD - 3 pts and PD in 2 pts. 3/3 RCC patients are evaluable for response with 1 PR, 1 SD and 1 PD. Conclusions: Pts to date have tolerated PERI + SUT well with no unexpected toxicities and clinical activity has been noted within the first 3 cohorts with 4 of 6 (67%) evaluable pts with advanced cancer achieving at least SD (≥ 6 mo’s). 1 PR has been seen. Accrual is in the last cohort and final results in this phase I will be updated at the meeting. Adverse Event Cohort 1 N=3 Cohort 2 N=3 Cohort 3 N=6 Cohort 4 N=2 PERI Dose (mg) 50 50 100 150 SUT Dose (mg) 25 50 50 50 Nausea 3 G1 2 G1 4 G1 1 G1, 1G2 Vomiting 1 G1 2 G1 1 G1, 1 G2 1 G3 Diarrhea 1 G1 3 G1, 1 G1 Fatigue 1 G1, 1 G2 1 G1, 1 G2 2 G2 2 G3 Hand/foot Syndrome 1 G1 1 G1 Rash 1 G1 1 G1 Hypertension 1 G3 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Keryx Biopharmaceuticals Keryx Biopharmaceuticals Keryx Biopharmaceuticals Keryx Biopharmaceuticals
A new synthesis of substituted dienes and its application to an alkylated taxane model system (1987)

A new synthesis of highly substituted dienes using LiCMe2SePh is reported, along with its application to the synthesis of the taxane model compound 8,12,15,15-tetramethyltricyclo[9.3.1.03,8]pentadecane.
Crystal structure of a putative aspartate aminotransferase belonging to subgroup IV (2004)

Protein TT0402 from Thermus thermophilus HB8 exhibits about 30-35% sequence identity with proteins belonging to subgroup IV in the aminotransferase family of the fold-type I pyridoxal 5'-phosphate (PLP)-dependent enzymes. In this study, we determined the crystal structure of TT0402 at 2.3 A resolution (R(factor) = 19.9%, R(free) = 23.6%). The overall structure of TT0402 exhibits the fold conserved in aminotransferases, and is most similar to that of the Escherichia coli phosphoserine aminotransferase, which belongs to subgroup IV but shares as little as 13% sequence identity with TT0402. Kinetic assays confirmed that TT0402 has higher transamination activities with the amino group donor, L-glutamate, and somewhat lower activities with L-aspartate. These results indicate that TT0402 is a subgroup IV aminotransferase for the synthesis/degradation of either L-aspartate or a similar compound.