gebhart/patrepeval huggingface dataset:
Computer-Controlled, Patient-Interactive, Multichannel, Implanted Neurological Stimulators (1987)

Programmable implantable neurological stimulation systems with multiple electrodes have many advantages in clinical use, but time-consuming postoperative adjustment of stimulation parameters is a distinct disadvantage. A personal computer interface to standard commercial radiofrequency-coupled devices has been developed, permitting direct patient interaction to expedite this process. In addition, the system permits simulated multichannel operation and implementation of various modulation schemes.
Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency (2023)

The sigmoid E<sub>max</sub> model was used to describe the rRNA synthesis ratio (RS ratio) response of Mycobacterium tuberculosis to antimicrobial concentration. RS-E<sub>max</sub> measures the maximal ability of a drug to inhibit the RS ratio and can be used to rank-order drugs based on their RS ratio effect. RS-EC<sub>90</sub> is the concentration needed to achieve 90% of the RS-E<sub>max</sub>, which may guide dose selection to achieve a maximal RS ratio effect <i>in vivo</i>.
SDF‐1 alpha Nanoglycan Complexes Exhibit Exended Retention Time and Beneficial Effect in Pulmonary Hypertension (2013)

SDF‐1α has been known to be an important stem cell homing factor, and exhibits pro‐angiogenic activity in vivo . Exogenously delivered SDF‐1α, however, has limited retention time in tissue, which is thought to be related to protease degradation or rapid diffusion into the circulation. In the present study, we formulated SDF‐1α nanoglycan complexes by mixing SDF‐1α with dextran sulfate and chitosan. The resulting complex particles showed diameters of 600–800 nm and a zeta potential of ~−40mV. In vitro release of SDF‐1α from the nanoglycan particles was extremely slow, 1–2% after 7 days at 37°C. In cell culture studies, the nanoglycan‐incorporated SDF‐1α (SDF‐1α NP) showed the same chemotactic activity as that of free SDF‐1α. SDF‐1α NP also activated CXCR4‐mediated phosphorylation of Akt and ERK similarly as that of free of SDF‐1α. Delivery of SDF‐1α to rat lungs by intratracheal aerosolization revealed that the retention time of SDF‐1α NP in the lung was significantly longer than that of free SDF‐1α (half‐life 2.8 hr vs 36 hr). Aerosolization of SDF‐ 1α NP, but not free SDF‐1α, was found to attenuate monocrotaline‐induced pulmonary hypertension in rats. This study demonstrated that functional SDF‐1α NPs have extended retention time in the lung and is beneficial in the treatment of pulmonary hypertension in rats. Supported by NIH grant HL107192.
ChemInform Abstract: Enhanced Reactivity in Homogeneous Gold Catalysis Through Hydrogen Bonding. (2014)

Abstract Additives that are good hydrogen‐bond acceptors increase the efficiency of gold‐catalyzed reactions in those instances where protodeauration is the rate‐determining step.
Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy (2016)

Progressing malignancies establish robust immunosuppressive networks that operate both systemically and locally. In particular, as tumors escape immunosurveillance, they recruit increasing amounts of myeloid and lymphoid cells that exert pronounced immunosuppressive effects. These cells not only prevent the natural recognition of growing neoplasms by the immune system, but also inhibit anticancer immune responses elicited by chemo-, radio- and immuno therapeutic interventions. Throughout the past decade, multiple strategies have been devised to counteract the accumulation or activation of tumor-infiltrating immunosuppressive cells for therapeutic purposes. Here, we review recent preclinical and clinical advances on the use of small molecules that target the immunological tumor microenvironment for cancer therapy. These agents include inhibitors of indoleamine 2,3-dioxigenase 1 (IDO1), prostaglandin E2, and specific cytokine receptors, as well as modulators of intratumoral purinergic signaling and arginine metabolism.
The complete sequence of a human genome (2022)

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium presents a complete 3.055 billion-base pair sequence of a human genome, T2T-CHM13, that includes gapless assemblies for all chromosomes except Y, corrects errors in the prior references, and introduces nearly 200 million base pairs of sequence containing 1956 gene predictions, 99 of which are predicted to be protein coding. The completed regions include all centromeric satellite arrays, recent segmental duplications, and the short arms of all five acrocentric chromosomes, unlocking these complex regions of the genome to variational and functional studies.
Seismological analysis of a train derailment (1976)

Research Article| June 01, 1976 Seismological analysis of a train derailment Leon Reiter; Leon Reiter School of Geology and Geophysics University of OklahomaNorman, Oklahoma 73069 Search for other works by this author on: GSW Google Scholar Don E. Bray Don E. Bray School of Aerospace Mechanical and Nuclear Engineering University of OklahomaNorman, Oklahoma 73069 Search for other works by this author on: GSW Google Scholar Bulletin of the Seismological Society of America (1976) 66 (3): 1007–1008. https://doi.org/10.1785/BSSA0660031007 Article history received: 10 Sep 1975 first online: 03 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Search Site Citation Leon Reiter, Don E. Bray; Seismological analysis of a train derailment. Bulletin of the Seismological Society of America 1976;; 66 (3): 1007–1008. doi: https://doi.org/10.1785/BSSA0660031007 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentBy SocietyBulletin of the Seismological Society of America Search Advanced Search This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not currently have access to this article.
Communication: Monte Carlo calculation of the exchange energy (2012)

In recent generalized Kohn-Sham (GKS) schemes for density functional theory (DFT) Hartree-Fock type exchange is important. In plane waves and grid approaches the high cost of exchange energy calculations makes these GKS considerably more expensive than Kohn-Sham DFT calculations. We develop a stochastic approach for speeding up the calculation of exchange for large systems. We show that stochastic error per particle does not grow and can even decrease with system size (at a given number of iterations). We discuss several alternative approaches and explain how these ideas can be included in the GKS framework.
Evolutionary Path Planning With Subpath Constraints (2010)

We develop an evolutionary method of planning paths that are subject to subpath constraints. These constraints can include subpaths that must be incorporated into the solution path, path intersection restrictions, and obstacle avoidance. Our method involves two stages. In the first stage, a global solution is found without consideration of any obstacles. In the second stage, local planning is performed to modify the global path to avoid obstacles. Stage one involves a fixed-length chromosome formulation of a genetic algorithm that utilizes existing operators and a new subpath reversal operator. Stage two involves a graph search process. Our algorithm is applicable to the field of printed electronics where continuous-spray processes are used to deposit electrically functional material onto flexible substrates. These processes give rise to the kinds of subpath constraints we have investigated. We evaluate our algorithm by applying it to a representative problem in the printed electronics field.
The monocyte binding domain(s) on human immunoglobulin G (1984)

Conference Article| October 01 1984 The monocyte binding domain(s) on human immunoglobulin G J. M. WOOF; J. M. WOOF 1Department of Biochemistry, University of Sheffield, Sheffield S10 2TN, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. R. BURTON D. R. BURTON 1Department of Biochemistry, University of Sheffield, Sheffield S10 2TN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1984 Biochemical Society1984 Biochem Soc Trans (1984) 12 (5): 746–747. https://doi.org/10.1042/bst0120746 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation J. M. WOOF, D. R. BURTON; The monocyte binding domain(s) on human immunoglobulin G. Biochem Soc Trans 1 October 1984; 12 (5): 746–747. doi: https://doi.org/10.1042/bst0120746 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: FcR, Fc receptor; Ig, immunoglobulin This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Mutual interference between DVB-SH and UMTS systems (2010)

Digital Video Broadcasting - Satellite services to Handhelds (DVB-SH) and UMTS networks are located in very close portions of the electromagnetic spectrum and can thus operate in adjacent frequency bands. Consequently, an assessment of their coexistence is of primary importance. This paper presents an investigation into the reciprocal interference between the two systems. A method to characterize interference based on RF coverage predictions is proposed and the expected Signal to Noise plus Interference Ratio (SNIR) degradation is quantified on the basis of the distance from the interference source. An example of the impact of these out-of-band emissions is provided for a specific use case and a set of on-field measurements is presented.
Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study (2022)

Tuberculosis (TB) education seeks to increase patient knowledge about TB, while TB counselling seeks to offer tailored advice and support for medication adherence. While universally recommended, little is known about how to provide effective, efficient, patient-centred TB education and counselling (TEC) in low-income, high HIV-TB burden settings. We sought to characterise stakeholder perceptions of TEC in a public, primary care facility in Kampala, Uganda, by conducting focus group discussions with health workers and TB patients in the TB and HIV clinics. Participants valued TEC but reported that high-quality TEC is rarely provided, because of a lack of time, space, staff, planning, and prioritisation given to TEC. To improve TEC, they recommended adopting practices that have proven effective in the HIV clinic, including better specifying educational content, and employing peer educators focused on TEC. Patients and health workers suggested that TEC should not only improve TB patient knowledge and adherence, but should also empower and assist all those undergoing evaluation for TB, whether confirmed or not, to educate their households and communities about TB. Community-engaged research with patients and front-line providers identified opportunities to streamline and standardise the delivery of TEC using a patient-centred, peer-educator model.
Hybrid Digital Optics (2009)

This chapter contains sections titled: Why Combine Different Optical Elements? Analysis of Lens Aberrations Improvement of Optical Functionality The Generation of Novel Optical Functionality Waveguide-based Hybrid Optics Reducing Weight, Size and Cost Specifying Hybrid Optics in Optical CAD/CAM A Parametric Design Example of Hybrid Optics via Ray-tracing Techniques
Protein induced lipid demixing in homogeneous membranes (2021)

Specific lipid environments are necessary for the establishment of protein signalling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model of protein induced local demixing of lipid membranes. The coupling between a local composition and a local thickness of the membrane induces lipid domains around inclusions with hydrophobic mismatch, even for temperatures above the miscibility critical point of the membrane. The model qualitatively explains the experimentally observed formation of lipid domains induced by anchoring of reconstituted actin in flat supported lipid bilayers.
Visible light communication-based monitoring for indoor environments using unsupervised learning (2021)

Visible Light Communication (VLC) systems provide not only illumination and data communications, but also indoor monitoring services if the effect that different events create on the received optical signal is properly tracked. For this purpose, the Channel State Information (CSI) that a VLC receiver computes to equalize the OFDM subcarriers can be reused to train an unsupervised learning classifier. This way, different clusters can be created on the collected CSI data, which could be then mapped into relevant events, such as the position of an object in the sensing area. When compared to supervised learning algorithms, the proposed approach does not need tags in the training data, simplifying notably the implementation. The validation of this monitoring approach was done using a software-defined VLC transmission based on OFDM, in which a reflected copy of the intensity modulated signal coming from a white LED was captured by a pair of photodetectors. The experimental evaluation of the VLC-based monitoring demo achieved a positioning accuracy in the few-centimeter-range, without the necessity of deploying a large number of sensors and/or adding a sensor on the object to-be-tracked.
Difference between 1-84 parathyroid hormone and the 1-34 fragment on renal tubular calcium transport in the dog. (1984)

Acute clearance studies were performed in chronically thyroparathyroidectomized dogs to determine similarities and differences between the effects of 1-34 and 1-84 parathyroid hormone (PTH) on urinary calcium excretion. In a small (physiological) dose, 1-84 PTH caused no mean change in percentage calcium excretion, while the 1-34 fragment was frankly calciuric. At this dose, the two hormone preparations were equally phosphaturic. Fragments of PTH in the range 25-84 did not alter calcium or phosphate transport. We conclude that the entire molecule is required in order for the distal nephron effect of the hormone to enhance net calcium transport in the kidney to become manifest.
The Effect of Daily Low Dose Gamma Irradiation on Growth and Differentiation of Human Myeloid Leukaemic Bone Marrow in Diffusion Chambers (1981)

Bone marrow from each of 8 untreated patients with myeloproliferative disorders was grown in diffusion chambers in 760 rad total body irradiated rats. Rats were then exposed to 11.5, 57.5, or 108.5 rad daily for 14-2l d and cell growth compared to that detected in unirradiated chambers. Cells from acute myelogenous leukaemia patients exposed to 11.5 rad per d grew for 11-21 d and there was no consistent stimulation of differentiation of immature granulocytic cells to mature granulocytes that was attributable to irradiation. Cells from a chronic myeloid leukaemia patient in chronic phase or blast crisis, and a polycythaemia vera patient with myeloid metaplasia showed significant morphologic differentiation from immature to mature granulocytes in control chambers with no additional effect of daily irradiation. Marrow specimens from 2 AML patients exposed to each of 3 daily dose fractions over 14 d revealed a dose-dependent decrease in immature granulocytes with no persistent increase in mature granulocytes. In both irradiated and control chambers, macrophages increased over 21 d. Thus, cells from patients with myeloproliferative disorders may not necessarily differentiate to mature granulocytes following in vivo exposure to ionizing irradiation.
Dealing with Multi-Scale Depth Changes and Motion in Depth Edge Detection (2006)

Sharp discontinuities in depth, or depth edges, are very important low-level features for scene understanding. Recently, we have proposed a solution to the depth edge detection problem using a simple modification of the capture setup: a multi-flash camera with flashes appropriately positioned to cast shadows along depth discontinuities in the scene. In this paper, we show that by varying illumination parameters, such as the number, spatial position, and wavelength of light sources, we are able to handle fundamental problems in depth edge detection, including multi-scale depth changes and motion. The robustness of our methods is demonstrated through our experimental results in complex scenes
Influenza A virus: sampling of the unique shorebird habitat at Delaware Bay, USA (2017)

Delaware (DE) Bay, in the northeastern USA, has long been recognized as a hotspot for avian influenza A virus (IAV); every spring, this coastal region serves as a brief stopover site for thousands of long-distance migrating shorebirds, en route to breeding grounds in the Arctic. During these stopovers, IAV has been consistently recovered from ruddy turnstones (<i>Arenaria interpres</i>) that are likely to become infected as they feed by probing sand and cobble in search of food. In May 2010-2012, we successfully isolated 19 IAV from environmental samples (sand, <i>n </i>= 18; horseshoe crab eggs, <i>n </i>= 1) obtained from DE Bay sites. Two of these viruses were subjected to laboratory conditions similar to those in the DE Bay spring-time environment, and remained infectious for 7 days. Here, through the recovery of IAV from environmental samples, temperature monitoring at and below the sand surface and simulated laboratory trials, we provide evidence that the beach environment may enable localized transmission and short-term maintenance of IAV in this unique ecosystem.
Dual-output modulation in time-wavelength interleaved photonic analog-to-digital converter based on actively mode-locked laser (2016)

This Letter demonstrates the application of dual-output modulation in a photonic analog-to-digital converter (PADC) with a high sampling rate and resolution. The PADC is time-wavelength interleaved and based on an actively mode-locked laser. According to theoretical analysis, the dual-output PADC system shows a better linearity for achieving a higher dynamic range. In the experiment, third-order distortion is significantly suppressed by ~40 dB when the dual-output modulator is used and the effective number of bits of the PADC has reached 9.0 bits below 0.2 GHz and 6.4 bits at 6.1 GHz in our PADC with a sampling rate of 20 GS/s.
Biocompatible MEMS Electrode Array for Determination of Three-Dimensional Strain (2006)

Sensor arrays for the measurement of the load condition of polyethylene spacers in the total knee arthroplasty (TKA) prosthesis have been developed. Arrays of capacitive sensors are used to determine the three-dimensional strain within the polyethylene prosthesis component. Data from these sensors can be used to give researchers better understanding of component motion, loading, and wear phenomena for a large range of activities. These sensors implemented on a large scale will give clinicians feedback for individual patient biomechanics without the requirement for patient exposure to X-ray radiation. Patients will benefit from smart prosthetic components which allow clinicians monitor biomechanics and loading by applying noninvasive remedies such as orthotics or physical therapy for patients exhibiting poor biomechanics before wear or component failure become issues. In this paper, we present research regarding the design of a biocompatible strain sensor and the fabrication of microelectrode arrays on biocompatible polymer materials
Comparative Study of Open-Loop Transmit Diversity Schemes for DFT-Precoded OFDMA in Frequency-Selective Fading Channels (2012)

This paper presents comprehensive comparisons based on the block error rate (BLER) of open-loop (OL) transmit diversity schemes considering a cubic metric (CM) for single-carrier (SC)-Frequency Division Multiple Access (FDMA) using discrete Fourier transform (DFT)-precoded OFDMA in uplink frequency-selective fading channels. The OL transmit diversity schemes assumed in the paper are space-time block code (STBC), space-frequency block code (SFBC), single-carrier (SC) - SFBC, cyclic delay diversity (CDD), and frequency switched transmit diversity (FSTD) for two antennas and a combination of STBC, SFBC, SC-SFBC and selection transmit diversity including time switched transmit diversity (TSTD) or FSTD for four antennas. We derive the most appropriate OL transmit diversity scheme for SC-FDMA using a frequency domain equalizer (FDE) with QPSK and 16QAM modulations and with various channel coding rates employing turbo coding. We investigate the best OL transmit diversity scheme under various propagation channel conditions including the fading maximum Doppler frequency and root mean square (r.m.s.) delay spread, and the fading correlation between transmitter/receiver antennas.
Electrostatics of Nanoparticle–Wall Interactions within Nanochannels: Role of Double-Layer Structure and Ion–Ion Correlations (2018)

We perform computational investigations of the electrolyte-mediated interactions of charged nanoparticles with the walls of nanochannels. We investigate the role of discrete ion effects, valence, and electrolyte strength on nanoparticle-wall interactions. We find for some of the multivalent charge regimes that the like-charged nanoparticles and walls can have attractive interactions. We study in detail these interactions and the free-energy profile for the nanoparticle-wall separation. We find there are energy barriers and energy minima giving preferred nanoparticle locations in the channel near the center and at a distance near to but separated from the channel walls. We characterize contributions from surface overcharging, condensed layers, and overlap of ion double layers. We perform our investigations using coarse-grained particle-level simulations with Brownian dynamics, classical density functional theory, and the mean-field Poisson-Boltzmann theory. We discuss the implications of our results for phenomena in nanoscale devices.
Pharmacological studies of a series of dermorphin related pentapeptides. (1983)

Pharmacological activity in vitro and in vivo of 17 pentapeptide analogs of dermorphin (opioid heptapeptide) are reported. Substitutions of the Tyr5 residue afford dermorphin related pentapeptides which are likely to discriminate between mu- and delta-receptors.
Anisotropy in magnetic and mechanical properties in textured Hiperco® FeCoV alloys (2000)

Hiperco ® FeCoV alloys are soft magnetic materials suitable for applications at high temperatures and under high stresses. We have studied the evolution of the rolling texture and its effects on the mechanical and magnetic properties after annealing the Hiperco® sheets at high temperatures. X-ray pole-figure measurements reveal that the main texture of the as-rolled HA50HS and HA50 sheets is {001}〈11̄0〉. This rolling texture causes the mechanical and magnetic properties to exhibit a uniaxial anisotropy, which is reduced by annealing.