gebhart/patrepeval huggingface dataset:
An entropy-based approach for the optimization of rain gauge network using satellite and ground-based data (2021)

Abstract Accurate and precise rainfall records are crucial for hydrological applications and water resources management. The accuracy and continuity of ground-based time series rely on the density and distribution of rain gauges over territories. In the context of a decline of rain gauge distribution, how to optimize and design optimal networks is still an unsolved issue. In this work, we present a method to optimize a ground-based rainfall network using satellite-based observations, maximizing the information content of the network. We combine Climate Prediction Center MORPhing technique (CMORPH) observations at ungauged locations with an existing rain gauge network in the Rio das Velhas catchment, in Brazil. We use a greedy ranking algorithm to rank the potential locations to place new sensors, based on their contribution to the joint entropy of the network. Results show that the most informative locations in the catchment correspond to those areas with the highest rainfall variability and that satellite observations can be successfully employed to optimize rainfall monitoring networks.
A non-volatile memory based physically unclonable function without helper data (2014)

Stability across environmental variations such as temperature and voltage, is critically important for Physically Unclonable Functions (PUFs). Nearly all existing PUF systems to date need a mechanism to deal with “bit flips” when exact regeneration of the bitstring is required, e.g., for cryptographic applications. Error correction (ECC) and error avoidance schemes have been proposed but both of these require helper data to be stored for the regeneration process. Unfortunately, helper data adds time and area overhead to the PUF system and provides opportunities for adversaries to reverse engineer the secret bitstring. In this paper, we propose a non-volatile memory-based (NVM) PUF that is able to avoid bit flips without requiring any type of helper data. A voltage-to-digital converter technique is described for digitizing the analog entropy source and a robust median-finding algorithm is proposed as the reprograming strategy. Analysis on published experimental data is presented to demonstrate the practicability of our proposed strategy. We describe the technique in the context of emerging nano-devices, in particular, resistive random access memory (Memristor) cells, but the methodology is applicable to any type of NVM including Flash.
Cannabis and the Brain: Friend or Foe? (2022)

Legalization of cannabis in the US and other countries highlight the need to understand the health consequences of this substance use. Research indicates that some cannabis ingredients may play beneficial role in treating various medical conditions while other ingredients may pose health risks. This review is focused on the brain and mental health effects of cannabis use. The rationale for examining cannabis use in behavioral and neural conditions is that these conditions are highly widespread in the US and account for high level of medical healthcare and associated cost. The purpose of this review is to provide an overview of the known medicinal benefits of selected cannabis cannabinoids in conditions like pediatric epilepsy, attention deficit hyperactivity disorder, autism spectrum disorder, and the known side effects or contraindications in conditions such as addiction, cognition, and psychosis. Several recommendations are made as to studies that will help further understanding the increasing role of cannabis in neuropsychiatric health and disease.
Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging (2019)

As the complexity of ultrasound signal processing algorithms increases, it becomes more difficult to demonstrate their added value and thus robust validation strategies are required. We propose a method of manufacturing ultrasonic vascular phantoms mimicking an atheromatous plaque in an internal carotid artery bifurcation for applications in flow imaging and elastography. During the fabrication process, a soft inclusion mimicking a stenotic lipid pool was embedded within the vascular wall. Mechanical testing measured Young's moduli of the vascular wall and soft inclusion at 342 ± 25 kPa and 17 ± 3 kPa, respectively. B-mode, color Doppler, power Doppler, shear wave elastography, and strain elastography images of the different phantoms were produced to show the validity of the fabrication process. Because of their realistic geometries and mechanical properties, those phantoms may become advantageous for fluid-structure experimental modeling and validation of new ultrasound-based imaging technologies.
Parampl: A Simple Tool for Parallel and Distributed Execution of AMPL Programs (2018)

Due to the physical processor frequency scaling constraint, current computer systems are equipped with more and more processing units. Therefore, parallel computing has become an important paradigm in the recent years. This paper presents Parampl, a simple tool for parallel and distributed execution of AMPL programs. AMPL is a comprehensive algebraic modeling language for formulating optimization problems. However, AMPL itself does not support defining tasks to be executed in parallel. Although the parallelism is often provided by solvers, in many cases, it is more efficient to formulate the problem in a decomposed way and apply various problem specific enhancements. Parampl introduces explicit asynchronous execution of AMPL subproblems from within the program code. Such an extension yields a new view on AMPL programs, where a programmer is able to define complex, parallelized optimization tasks and formulate algorithms solving optimization subproblems in parallel or in a distributed manner.
Analysis of Constraints for Optimal Electric Vehicle Charging (2014)

The increasing uptake of electric vehicles is likely to put a significant demand on the electricity grid. However, expensive infrastructure upgrades can be avoided if some of the vehicle charging can be shifted to off-peak times. We express electric vehicle charging as a receding horizon optimisation problem in which inherent network limitations are taken into account as linear constraints. By tuning these constraints, it is possible to push total system performance in one direction or another as required, and to adapt the solution to a variety of networks and to different sets of network limitations. We explore in detail this tuning process and discuss the trade-offs involved. There are several emergent benefits from examining the constraints in this way: a capacity constraint can be used to prevent peak load increases; a phase unbalance constraint can be used to enforce system rebalancing; and a voltage limit constraint can ensure that vehicle charging does not push voltages outside allowed limits. Our conclusions are demonstrated in simulation studies that use a model of a real network, as well as real demand and vehicle travel data.
Structure of dilithio-(E)-1,4-bis(trimethylsilyl)but-2-ene by x-ray crystallography and 1H-7Li HOESY (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of dilithio-(E)-1,4-bis(trimethylsilyl)but-2-ene by x-ray crystallography and 1H-7Li HOESYLeslie D. Field, Michael G. Gardiner, Barbara A. Messerle, and Colin L. RastonCite this: Organometallics 1992, 11, 11, 3566–3570Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/om00059a020https://doi.org/10.1021/om00059a020research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Figure S13 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies (2023)

&lt;p&gt;Supplementary Figure S13. A. 3D in vitro experimental setup. Human PBMCs and SU-DHL-8 tumor cells were co-cultured in a ratio of 5:1 and treated with 0.01 nM CD20-TCB in the presence or absence of 5 μg/mL adalimumab for 24 hrs. Supernatant from the co-cultures was transferred to the bottom channel of the Mimetas OrganoPlate®. PBMCs derived from the same donor as in the co-cultures, are fluorescently labeled and seeded in the upper channel of the Mimetas OrganoPlate®, where endothelial tubules have been previously formed. Mimetas OrganoPlate® are then imaged with the Operetta System to quantify fluorescent cell transmigration at 24 hrs. B. Shown is the cell migration towards cytokine-rich supernatants in the Mimetas OrganoPlate®. TNF-α pretreatment of the endothelial tubule is a positive control. Means of technical replicates from 2 independent experiment +/- SD with ****p&lt;0.0001, **p&lt;0.001 by 2 way ANOVA.&lt;/p&gt;
Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis (2002)

Taken together these results suggest that antigenic variation in B. recurrentis may result from recombination of variable large and small protein genes at the junction between lipoprotein leader sequence and mature protein coding region. However, this hypothetical model needs to be validated by further identification of expressed and silent variant protein genes in other B. recurrentis isolates.
ChemInform Abstract: Reactions of (Cp(CO)2Fe=CHAr)+ (Ar: p‐C6H4OMe) with O=N‐Ar′ (Ar′: C6H5, p‐C6H4NMe2) and PhN=NPh. (1990)

Abstract The organometallic products formed in the title reactions reflect net insertion of the nitroso or azo unit into the iron‐carbene bond.
Graph Signal Denoising Via Unrolling Networks (2021)

We propose an interpretable graph neural network framework to denoise single or multiple noisy graph signals. The proposed graph unrolling networks expand algorithm unrolling to the graph domain and provide an interpretation of the architecture design from a signal processing perspective. We unroll an iterative denoising algorithm by mapping each iteration into a single network layer where the feed-forward process is equivalent to iteratively denoising graph signals. We train the graph unrolling networks through unsupervised learning, where the input noisy graph signals are used to supervise the networks. By leveraging the learning ability of neural networks, we adaptively capture appropriate priors from input noisy graph signals, instead of manually choosing signal priors. To validate the proposed methods, we conduct extensive experiments on both real-world datasets and simulated datasets, and demonstrate that our methods have smaller denoising errors than conventional denoising algorithms and state-of-the-art graph neural networks. For denoising a single smooth graph signal, the normalized mean square error of the proposed networks is around 40% and 60% lower than that of graph Laplacian denoising and graph wavelets, respectively.
Pyridoxine‐unresponsive homocystinuria with an unusual clinical course (1990)

Progressive premature atherosclerosis and associated thromboembolic complications are the main causes of morbidity and mortality in patients with homocystinuria. However, thrombosis is rarely the predominant or presenting manifestation leading to the diagnosis of homocystinuria. We report on an otherwise asymptomatic teenage boy of normal intelligence who had a superior sagittal sinus thrombosis documented by CT and MRI scans. He presented with pneumothoraces, papilledema, and transient right hemiparesis. He subsequently developed empyema and necrotizing pneumonia as well as deep venous thromboses. The diagnosis of pyridoxine-unresponsive homocystinuria was made on the basis of clinical chemistry analyses, enzyme assay, and clinical trial. He has remained symptom-free under treatment with betaine and methionine restriction. We suggest that there exists a subset of patients with pyridoxine-unresponsive homocystinuria who are at risk for thromboembolism, but who may remain undiagnosed because of an otherwise mild clinical course.
Towards Situated Collaboration (2012)

We outline a set of key challenges for dialog management in physically situated interactive systems, and propose a core shift in perspec-tive that places spoken dialog in the context of the larger collaborative challenge of managing parallel, coordinated actions in the open world. Multiple models for dialog management have been proposed, studied, and evaluated in the research community (i.a. Allen et al, 2001; Bohus and Rud-
Non-quasi-static model for MOSFET based on carrier-transit delay (2004)

A non-quasi-static MOSFET model for circuit simulation, which is based on the carrier-transit delay responsible for the channel formation during switching on, has been developed. The developed model was implemented into a circuit simulator, and good agreement of transient drain current with 2D simulation results was confirmed.
Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection (2021)

Monoclonal antibody (MAb) 2C7 recognizes a lipooligosaccharide epitope expressed by most clinical <i>Neisseria gonorrhoeae</i> isolates and mediates complement-dependent bactericidal activity. We recently showed that a recombinant human IgG1 chimeric variant of MAb 2C7 containing an E430G Fc modification (2C7_E430G), which enhances complement activation, outperformed the parental MAb 2C7 (2C7_WT) <i>in vivo</i> Because natural infection with <i>N. gonorrhoeae</i> often does not elicit protective immunity and reinfections are common, approaches that prolong bacterial control <i>in vivo</i> are of great interest. Advances in DNA-based approaches have demonstrated the combined benefit of genetic engineering, formulation optimizations, and facilitated delivery via CELLECTRA-EP technology, which can induce robust <i>in vivo</i> expression of protective DNA-encoded monoclonal antibodies (DMAbs) with durable serum activity relative to traditional recombinant MAb therapies. Here, we created optimized 2C7-derived DMAbs encoding the parental Fc (2C7_WT) or complement-enhancing Fc variants (2C7_E430G and 2C7_E345K). 2C7 DMAbs were rapidly generated and detected throughout the 4-month study. While all complement-engaging 2C7 variants facilitated rapid clearance following primary <i>N. gonorrhoeae</i> challenge (day 8 after DMAb administration), the complement-enhancing 2C7_E430G variant demonstrated significantly higher potency against mice rechallenged 65 days after DMAb administration. Passive intravenous transfer of <i>in vivo</i>-produced, purified 2C7 DMAbs confirmed the increased potency of the complement-enhancing variants. This study highlights the ability of the DMAb platform to launch the <i>in vivo</i> production of antibodies engineered to promote and optimize downstream innate effector mechanisms such as complement-mediated killing, leading to hastened bacterial elimination.<b>IMPORTANCE</b><i>Neisseria gonorrhoeae</i> has become resistant to most antibiotics in clinical use. Currently, there is no safe and effective vaccine against gonorrhea. Measures to prevent the spread of gonorrhea are a global health priority. A monoclonal antibody (MAb) called 2C7, directed against a lipooligosaccharide glycan epitope expressed by most clinical isolates, displays complement-dependent bactericidal activity and hastens clearance of gonococcal vaginal colonization in mice. Fc mutations in a human IgG1 chimeric version of MAb 2C7 further enhance complement activation, and the resulting MAb displays greater activity than wild-type MAb 2C7 <i>in vivo</i> Here, we utilized a DNA-encoded MAb (DMAb) construct designed to launch production and assembly of "complement-enhanced" chimeric MAb 2C7 <i>in vivo</i> The ensuing rapid and sustained MAb 2C7 expression attenuated gonococcal colonization in mice at 8 days as well as 65 days postadministration. The DMAb system may provide an effective, economical platform to deliver MAbs for durable protection against gonorrhea.
The Solid State Postcondensation of PET, 2 (2004)

International audience
Gait Analysis in Coxarthrosis (2005)

The purpose of this study was to identify temporal gait parameters in coxarthrosis.In this report, gait analysis was performed on 20 patients (all females; mean age 61.2 years) who had total hip arthroplasty from May to September 2004.All patients were tested during "free" walking along an 5-m walkway in which a ground reaction force plate (gait scan 8000; Nitta, Inc.) was installed. Normal average values reported by Murray et al.2 ) were used. As an index of pain, the Japanese Orthopaedic Association (JOA) pain score was used.Single support duration was compared with the involved and normal legs. Single support duration of the involved leg decreased in 19 patients. Moreover, compared with normal values, in the normal leg, those of most patients remained unchanged. In the involved leg, single support duration of all patients decreased from the normal value. Single support duration of the involved leg decreased as JOA pain score decreased. Double support duration of both legs increased as JOA pain score decreased. The results of gait analysis can be used as an objective index of hip pain.
Abstract 5902: Integrative genomic analysis of checkpoint blockade in lung cancer: A multi-institution SU2C collaborative (2020)

Abstract PD-1/PD-L1 checkpoint blockade has been a landmark advance for many patients suffering from advanced non-small cell lung cancer (NSCLC). However, detailed biomarkers of response beyond tumor mutational burden (TMB) are still poorly understood. As part of the effort to elucidate these additional signatures, we describe our progress on the Stand Up to Cancer Lung (SU2C-Lung) cohort. Initial characterization of exomes recapitulates mutational and copy number profiles seen in The Cancer Genome Atlas (TCGA) project. To better define expression subtypes using RNA sequencing, we performed non-negative matrix factorization (NMF) across an aggregated set of publicly available NSCLC expression data (including adenocarcinoma, squamous cell carcinoma, and large cell neuroendocrine histologies), and demonstrate good concordance in the SU2C-Lung cohort between this expression-based classifier and clinically annotated histology. To gain further insight into how immune cell infiltrates vary across our cohort, we additionally tested two common deconvolution algorithms, EPIC and CIBERSORT. While these two methods agree for some prominent cell types, such as B cells and CD4 T cells, discrepancies in minor infiltrating components such as NK cells may suggest a limit to the inference of rare subpopulations from bulk sequencing data.Finally, we describe a novel approach for determining single-gene predictors of response. Using the method, which is based on comparison of top single transcriptional features identified from random bootstraps of the full cohort as compared to a set of background shuffles, we are able to show that we remain powered for discovery of RNA response biomarkers despite the typically burdensome toll of multiple hypothesis correction at genome wide scale. Acknowledgment: Supported by Stand Up To Cancer-American Cancer Society Lung Cancer Dream Team Translational Research Grant SU2C-AACR-DT17-15. Citation Format: Monica Arniella, Arvind Ravi, Chip Stewart, Sam Freeman, Mark Awad, Patrick Forde, Valsamo Anagnostou, Brian Henick, Jonathan Riess, Don Gibbons, Nathan Pennell, Vamsidhar Velcheti, Ignaty Leshchiner, Jaegil Kim, Subba Digumarthy, Mari Mino-Kenudson, John Heymach, Nir Hacohen, Naiyer Rizvi, Roy Herbst, Victor Velculescu, Julie Brahmer, Kurt Schalper, Pasi Jänne, Jedd Wolchok, Alice Shaw, Justin Gainor, Matthew Hellmann, Gad Getz. Integrative genomic analysis of checkpoint blockade in lung cancer: A multi-institution SU2C collaborative [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5902.
Meander line loop antenna with coupled feed for multiband mobile phone (2011)

In this paper, the small loop antenna with coupled feed for multiband mobile phone is proposed. This antenna is composed of a feed monopole, radiating loop and parasitic element. This antenna is printed on the very thin flexible substrate to mount on the dielectric carrier with a volume of 40 mm×10 mm×3 mm. The bandwidth of the proposed antenna is 592 MHz (785-1377 MHz) for low band and 361 MHz (1816-2177 MHz) for high band for a 3:1 VSWR. Thus, the proposed antenna covers the four bands of GSM850 (824-894 MHz), GSM900 (880-960 MHz), PCS (1850-1990 MHz), and UMTS (1920-2170 MHz). Moreover, the measured radiation pattern and gain are appropriate for mobile handset. Therefore, this antenna is suitable for small sized multiband mobile phone applications.
Dictionary design for sensor network localization via block-sparsity (2015)

In this paper, we consider the problem of RSS-fingerprinting localization in wireless sensor networks. In particular, inspired by the recent advances in sparse approximation and compressive sensing theory, we propose a localization scheme based on the dictionary design of block-sparse signals. We show via numerical simulations and real experiments that the proposed technique outperforms traditional fingerprinting methods.
Bronchial gene expression alterations associated with radiological bronchiectasis (2022)

Genes involved in cell adhesion, Wnt signalling, ciliogenesis and interferon-γ pathways had altered expression in the bronchus of participants with widespread radiological bronchiectasis, possibly associated with decreased basal and increased ciliated cells. This gene expression pattern is not only highly enriched among individuals with radiological bronchiectasis, but also associated with airway-related symptoms in those without discernible radiological bronchiectasis, suggesting that it reflects a bronchiectasis-associated, but non-bronchiectasis-specific lung pathophysiological process.
ChemInform Abstract: Catalytic Routes to Hydro(chloro)fluorocarbons (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.