gebhart/patrepeval huggingface dataset:
1-Hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) (2009)

[104439-77-2] C62H42O6Ru2 (MW 1085.13) InChI = 1S/2C29H21O.4CO.2Ru/c2*30-29-27(23-17-9-3-10-18-23)25(21-13-5-1-6-14-21)26(22-15-7-2-8-16-22)28(29)24-19-11-4-12-20-24;4*1-2;;/h2*1-20,30H;;;;;; InChIKey = CJXMWRIOTYFOAD-UHFFFAOYSA-N (oxidation, reduction, racemization, dynamic kinetic resolution, dynamic kinetic asymmetric transfermation) Alternative Name: Shvo's catalyst. Physical Data: melting point 223–227 °C. Solubility: most polar solvents (toluene, CH2Cl2, THF, 2-propanol); reacts with alcohols. Formed Supplied in: light orange crystalline solid. Analysis of Reagent Purity: 1H NMR. Integrate the bridging hydride to the aromatic region (40:1). Preparative Methods: recrystallized from CH2Cl2 and pentane. Handling, Storage, and Precautions: solid Shvo's catalyst is substantially stable to air.
Real-Time Time-Resolved Optical Measurements using a Digital Adaptive Filter (2018)

We demonstrate a novel phosphorescence lifetime imaging microscopy technique using a pseudo-random modulated laser source for excitation, and an adaptive filter for resolving the detected emission. Our results show clear lifetime differences between the oxygenated and deoxygenated solutions of a ruthenium dye.
Antimalarial Activities of Novel SyntheticCysteine ProteaseInhibitors (2003)

Among promising new targets for antimalarial chemotherapy are the cysteine protease hemoglobinases falcipain-2 and falcipain-3. We evaluated the activities of synthetic peptidyl aldehyde and alpha-ketoamide cysteine protease inhibitors against these proteases, against cultured Plasmodium falciparum parasites, and in a murine malaria model. Optimized compounds inhibited falcipain-2 and falcipain-3, blocked hemoglobin hydrolysis, and prevented the development of P. falciparum at nanomolar concentrations. The compounds were equally active against multiple strains of P. falciparum with varied sensitivities to standard antimalarial agents. The peptidyl inhibitors were consistently less active against vinckepain-2, the putative falcipain-2 and falcipain-3 ortholog of the rodent malaria parasite Plasmodium vinckei. The lead compound morpholinocarbonyl-leucine-homophenylalanine aldehyde, which blocked P. falciparum development at low nanomolar concentrations, was tested in a murine P. vinckei model. When infused continuously at a rate of 30 mg/kg of body weight/day, the compound delayed the progression of malaria but did not eradicate infections. Our data demonstrate the potent antimalarial activities of novel cysteine protease inhibitors. Additionally, they highlight the importance of consideration of the specific enzyme targets of animal model parasites. In the case of falcipains, differences between P. falciparum and rodent parasites complicate the use of the rodent malaria model in the drug discovery process.
Drug targeting to lysosomes (1984)

Conference Article| December 01 1984 Drug targeting to lysosomes RUTH DUNCAN; RUTH DUNCAN *Department of Biological Sciences, University of Keele, Keele, Staffs. ST5 5BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar JINDŘICH KOPEČEK; JINDŘICH KOPEČEK †Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, 162 06 Prague 6, Czechoslovakia Search for other works by this author on: This Site PubMed Google Scholar JOHN B. LLOYD JOHN B. LLOYD *Department of Biological Sciences, University of Keele, Keele, Staffs. ST5 5BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (6): 913–915. https://doi.org/10.1042/bst0120913 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation RUTH DUNCAN, JINDŘICH KOPEČEK, JOHN B. LLOYD; Drug targeting to lysosomes. Biochem Soc Trans 1 December 1984; 12 (6): 913–915. doi: https://doi.org/10.1042/bst0120913 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Ion Substitution Effect on Defect Formation in Two-Dimensional Transition Metal Nitride Semiconductors, AETiN2 (AE = Ca, Sr, and Ba) (2021)

A layered semiconductor, SrTiN<sub>2</sub>, has an interesting crystal structure as a two-dimensional (2D) electron system embedded in a three-dimensional bulk periodic structure because it has alternate stacking of a SrN blocking layer and a TiN conduction layer, in which the Ti 3d<sub>xy</sub> orbital forms the conduction band minimum (CBM) similar to the SrTiO<sub>3</sub>-based thin-film heterostructure. However, SrTiN<sub>2</sub> has been reported to exhibit nearly degenerate conduction, but we reported that it would be due to the easy formation of nitrogen vacancies and oxygen impurities from air. In this paper, we extend the materials to family compounds, alkaline earth (<i>AE</i>) ion-substituted, <i>AE</i>TiN<sub>2</sub> (<i>AE</i> = Ca, Sr, and Ba), and investigated how we can suppress the defect formation by (hybrid) density functional theory calculations. All <i>AE</i>TiN<sub>2</sub> compounds possess thermodynamic stability in the wide nitrogen (N) chemical potential window. Especially, CaTiN<sub>2</sub> is the most stable even against N-poor conditions. Unintentional carrier generation occurs due to the nitrogen vacancies (<i>V</i><sub>N</sub>), oxygen substitution (O<sub>N</sub>), and hydrogen anion substitution (H<sub>N</sub>) at the nitrogen sites. The <i>V</i><sub>N</sub> and H<sub>N</sub> impurities can be suppressed under N-moderate and N-rich conditions. The O<sub>N</sub> defect is easily formed in SrTiN<sub>2</sub> and also in BaTiN<sub>2</sub> under N-rich conditions, but its formation can be suppressed in CaTiN<sub>2</sub>. Present results suggest that high-purity CaTiN<sub>2</sub> can be obtained under wider N chemical conditions, which would lead to the realization of the novel functional properties originating from Ti 3d<sub>xy</sub> 2D bands embedded in the bulk crystal structure.
Hugh Charles Brent Reed (2021)

A vet who was well known in the field of artificial insemination of pigs.
#5093 DIALYSIS PATIENTS AND BNT162B2MRNA VACCINE TYPE ARE RISK FACTORS FOR IMMUNITY FADING 9 MONTHS AFTER SARS-COV-2MRNA VACCINATION (DIA-VACC STUDY) (2023)

Abstract Background and Aims SARS-CoV-2mRNA vaccination related seroconversion rates are reduced in dialysis (DP) and kidney transplant patients (KTR). Recently, we demonstrated that established vaccination related immunity (via positive seroconversion) fades faster in DP and at a lesser extent in KTR compared to medical personnel (MP).[1] We hypothesized that a longer follow up period might be able to profoundly show immunity fading differences specific to different patient groups and identify strong fading risk factors that are relevant for patient management especially in vulnerable groups. Method We evaluated nine months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 880 participants including healthy MP (125), DP (595), KTR (111), and apheresis patients (49-AP) with positive seroconversion (de novo IgA or IgG antibody positivity by ELISA) after eight weeks. Results Nine months after first vaccination, receptor binding domain (RBD) antibodies were still positive in 90 % of MP, 86 % of AP, but only 55 %/48 % of DP/KTR, respectively. Seroconversion remained positive in 100 % of AP and 99·2 % of MP, but 86 %/81 % of DP/KTR, respectively. Compared to MP, DP but not KTR or AP were at risk for a strong RBD decline, while KTR kept lowest RBD values over time (see Fig. 1 and Table 1). By multivariate analysis, BNT162b2mRNA versus 1273-mRNA vaccine type was an independent risk factor for a strong decline of RBD antibodies. Within the DP group, only time on dialysis was another (inverse) risk factor for the DP group. Compared to humoral immunity, T-cell immunity decline was less prominent. Conclusion While seroconverted KTR reach lowest RBD values over time, DP are at specific risk for a strong decline of RBD antibodies after successful SARS-CoV-2mRNA vaccination, which also depends on the vaccine type being used. Therefore, booster vaccinations for DP should be considered earlier compared to normal population.
The Electronic Structures of Octahedral Metal Complexes. I. Metal Hexacarbonyls and Hexacyanides (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electronic Structures of Octahedral Metal Complexes. I. Metal Hexacarbonyls and HexacyanidesHarry B. Gray and N. A. BeachCite this: J. Am. Chem. Soc. 1963, 85, 19, 2922–2927Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ja00902a014https://doi.org/10.1021/ja00902a014research-articleACS PublicationsRequest reuse permissionsArticle Views1355Altmetric-Citations211LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-throw low-pressure sputtering technology for very large-scale integrated devices (1995)

For the next generation of semiconductor devices, new metal deposition technologies (such as Cu and Ti chemical vapor deposition) are being developed. As very large-scale integrated fabrication becomes more highly integrated, the size of contact/via holes must shrink, producing higher aspect ratios. These geometries create major difficulties in obtaining acceptable step coverage of the barrier/glue layer within the contact/via holes. A new technology has been developed, called long-throw sputter (LTS), for achieving acceptable step coverage particularly for geometries below 0.5 μm without employing collimators in the system. LTS (patent pending) provides more than 40% bottom coverage of barrier metal films in 0.35 μm contact holes with 3.0 aspect ratio while maintaining a high deposition rate and acceptable film uniformity. Additionally, LTS may facilitate Al alloy flow and/or reflow application.
A Cooperative Computing Strategy for Blockchain-Secured Fog Computing (2020)

Fog computing is an emerging paradigm in provisioning computing and storage resources for the Internet-of-Things (IoT) devices. In a fog computing system, all devices can offload their data or computationally intensive tasks to nearby fog nodes, instead of to the distant cloud. As compared with cloud computing, fog computing can significantly reduce the transmission delay between IoT devices and computing servers. However, the current fog system is rather susceptible to malicious attacks. To increase the security level, we propose to partition the fog system into fog node clusters (FNCs), with fog nodes (FNs) in one cluster sharing the same access control list (ACL) which is protected by a blockchain. Generating blockchains requires tremendous computing power and can rapidly drain the computing capacities of FNs. In this article, we first customize the blockchain for FNC to reduce the required computing power consumption and storage spaces. Second, a new scheme is designed for the blockchain-based FNC (BFNC) to recover ACL automatically. In addition, we propose a heuristic algorithm to reduce the time to acquire hash values of blocks by computing cooperatively with all available devices. The simulation results have demonstrated that using the cooperative computing strategy can reduce the time of computing a block hash than noncooperative strategies.
Shorter SRv6 SID Requirements (2020)

This document describes a list of requirements for the use of a
shortened identifier in a segment routing network with the IPv6 data
plane.
Ontogeny of the Stress Response in the Rat: Role of the Pituitary and the Hypothalamus* (1986)

The neonatal rat shows a period of decreased responsiveness to noxious stimuli during the first 3 weeks of life, but the nature of this impairment is still controversial. To test the functionality of the hypothalamus-pituitary-adrenal axis during this period, we studied pituitary and adrenal responsiveness to exogenous ovine CRF and the ability of various stressors (ether vapors, electroshocks, and hypoxia) to elicit ACTH and corticosterone secretion. We also measured hypothalamic CRF content and pituitary ACTH content as well as CRF-binding sites in the anterior pituitary. From days 3-10, small elevations in plasma ACTH and corticosterone levels were observed after a 3-min exposure to ether vapors or electroshocks. In contrast, during this period, a 20-min exposure to hypoxia (5% O2 in N2) was unable to trigger measurable ACTH secretion, while corticosterone was significantly elevated. From days 14-21, plasma ACTH and corticosterone levels increased significantly after exposure to ether stress, hypoxia, and, to a lesser extent, electroshocks. By contrast, administration of urethane (1.2 g/kg BW) caused a significant increase in ACTH secretion on days 3, 5, and 10, an effect that was partially suppressed by pretreatment with an anti-CRF serum. This suggests that endogenous CRF can be released by at least some stimuli as early as day 3. Direct stimulation of the pituitary with synthetic oCRF (10 micrograms/kg BW) caused significant elevations in plasma ACTH levels at all ages tested (days 3 through 21), though these increases were significantly (P less than or equal to 0.01) smaller on day 3 (2.7-fold) than on day 21 (4.3-fold). Hypothalamic CRF content as well as ACTH content increased gradually with age, but the values reached by the third week of life were still low compared to the values on day 45. Finally, anterior pituitary CRF-binding sites averaged 317 +/- 48 fmol/mg protein on day 5 and 158 +/- 22 fmol/mg protein on day 17. The affinity (Kd) of the receptor for CRF was not significantly different on day 5, 17, or 45. These results show that although pituitary corticotrophs appear to be functional at birth, exposure to stress does not elicit marked increases in plasma ACTH until day 14 of age.
Static and dynamic performance of micropower transistor logic circuits (1964)

Digital transistor circuits operating in the "micropower" range (viz., 1 to 1000 µw per gate) are needed in the portable electronic equipments of a modern field army. The most basic micropower transistor requirements are, 1) junction reverse currents which are small compared with minimum operating currents, 2) useable device current gains at minimum operating currents, and 3) minimum junction capacitances in order to enhance switching speed. The micropower performance capabilities of modified direct coupled transistor logic (DCTL), diode transistor logic (DTL) and transistor transistor logic (TTL) circuits are sufficient to satisfy the present and projected requirements of many portable equipment applications. The normal operating temperature range, logic capability, and tolerance immunity of the circuits need not be compromised. Somewhat reduced stability margins may be necessary but are permissible due to lower operating power levels. Markedly reduced operating speeds are unavoidable but not at all detrimental since audio clock frequencies suffice for many portable equipments. In order to maintain adequate over-all performance, a minimum saturated transistor collector current I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CS</inf> is required in a micropower logic gate. This minimum is most sensitive to the maximum operating temperature of the circuit. The feasibility of implementing a particular micropower circuit design by means of hybrid thin-film techniques or integrated silicon techniques depends principally on the large total circuit resistance values encountered in micropower designs.
Arthroscopic Management of Anterior Glenoid Bone Loss (2020)

Anterior glenohumeral instability is a complex problem that requires careful attention to osseous and soft-tissue lesions in order to treat it effectively. The arthroscopic soft-tissue Bankart repair is considered first-line treatment for patients with anterior glenohumeral instability. However, recent long-term outcome studies have shown surprisingly high failure rates, specifically in the setting of anterior glenoid bone loss. The definition of "critical" glenoid bone loss that cannot be overcome by a soft-tissue procedure alone continues to evolve and may in fact be lower than the previously published total of 20%. Arthroscopic reconstruction of the anterior glenoid margin can be performed with either autograft or allograft. The arthroscopic Latarjet procedure has emerged as a reliable and effective technique for autograft augmentation, while the distal aspect of the tibia appears to be a promising source of allograft.
Integrated Lasers on Silicon at Communication Wavelength: A Progress Review (2022)

Abstract With the emerging trend of big data and internet of things, silicon (Si) photonics technology has been developed and applied for high‐bandwidth data transmission. Contributed by the advantages of Si including high refractive index, low loss, significant thermal‐optical effect, and CMOS compatibility, various functional photonic devices have been demonstrated. One exception is the laser source, which is limited by the indirect bandgap of Si. Researchers have come up with different ways to make lasers on Si. This review presents the development progress of integrated laser sources on Si, with the focus on the wavelength regimes for communication. These lasers are categorized based on their gain media, including III–V semiconductor‐based laser, germanium/germanium tin‐based laser, Raman‐based laser, and rare‐earth‐doped laser. The laser performance and characteristics are summarized in tables for comparison. The key results are discussed. Future perspectives on the development of integrated lasers on Si have also been provided.
Metabolic pre‐conditioning of cultured cells in physiological levels of insulin: Generating resistance to the lipid‐accumulating effects of plasma in hepatocytes (2002)

Figure Freshly isolated hepatocytes were pre-conditioned in high insulin (s,h) or low insulin (d,j) containing medium for 6 days prior to switching to culture in unsupplemented plasma (s,d) or amino acid-supplemented plasma (h,j). Plasma culture was initiated on Day 0. n 9. *: p<0.05.
Supplementary Material for: Cotton Wool Spots after Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Associated with Central Retinal Vein Occlusion (2016)

<b><i>Purpose:</i></b> To report a case series, whereby we encountered a transient increase in retinal cotton wool spots (CWS) following anti-vascular endothelial growth factor (anti-VEGF) therapy for the treatment of macular edema secondary to central retinal vein occlusion (CRVO). <b><i>Methods:</i></b> Eighteen eyes were treated with intravitreal aflibercept (IVA), and 5 were treated with intravitreal ranibizumab (IVR). Fundus photographs obtained 1 month after initial IVA or IVR injections were retrospectively evaluated for the presence of CWS. <b><i>Results:</i></b> Twenty-one (91.3%) patients had the following systemic diseases: hypertension, diabetes mellitus without retinopathy, dyslipidemia, or chronic renal failure requiring dialysis. One month after treatment, reduced macular edema was observed in 21 (91.3%) eyes. Initial injections facilitated complete resolution in 14 eyes, and CWS gradually became fainter with additional injections. <b><i>Conclusion:</i></b> Some eyes with CRVO-related macular edema can show a transient increase in CWS after initial anti-VEGF therapy; however, macular edema, retinal hemorrhage, and visual acuity were improved in almost every case.
In vitro evaluation of antiviral activity of Sisybrium irio (Khaksi) against SARS-COV-2. (2022)

SARS-CoV-2 pandemic, drawn attention to the need of virus culture. In vitro SARS-COV-2 culture was performed to carry out therapeutic, environmental and virus genome studies. Isolation of virus from nasopharyngeal swab was performed by inoculating virus positive samples in available cell lines. SARS-CoV-2 topography was observed by using Scanning Electron Microscopy (SEM). Virus specificity was defined by serological confirmation through neutralization assay with COVID 19 convalescent sera. The SARS-COV-2 virus replicated successfully in Vero cell lines (both in E6 and CCL-81). The TCID50 and PFUs of isolated virus were defined as 10<sup>7</sup> TCID<sub>50</sub>/mL and 1.4 Х 10<sup>6</sup> pfu/mL respectively. The virus particles with the SARS-CoV morphology was <150ɳM size. Virus inhibition in presence of convalescent sera of COVID-19 patients was observed. Sisybrium irio (Khaksi) was found cytotoxic on Vero E6 cell line and its antiviral activity could not be established against SARS-COV-2 virus in vitro. Successful isolated and archived native SARS-COV-2 may be utilized further for therapeutic, environmental and virus genome sequencing studies.
Thermal micropressure sensor for pressure monitoring in a minute package (2001)

A thermal micropressure sensor suitable for pressure measurements in the range from 7×10−3 to 1×105 Pa has been fabricated by forming a titanium (Ti) thin-film resistor on a floating nondoped silica glass membrane, with the sensing area being as small as 60 μm×60 μm. The sensor performance is raised by: (1) increasing the ratio of gaseous thermal conduction in the total thermal conduction by sensor structure design; (2) compensating the effect of ambient-temperature drift by using a reference resistor located close to the sensing element but directly on the silicon substrate; and (3) utilizing an optimized novel constant-bias Wheatstone bridge circuit. By choosing a proper bias voltage, which can be found by simple calculation, the circuit extracts information on gaseous thermal conduction from the directly measurable total heat loss of the heated sensing element. The sensor was enclosed in a metal package with a capacity of about 0.5 ml by projection welding and was successfully applied to monitoring the pressure in the minute space.
Scanning Fiber Endoscopy with New Technologies and Forward-Viewing Applications (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. Seibel, "Scanning Fiber Endoscopy with New Technologies and Forward-Viewing Applications," in Frontiers in Optics 2016, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper FF1A.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article