gebhart/patrepeval huggingface dataset:
Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia (2020)

Background Type 1 interferon (IFN) has a long history in the treatment of cancer, including hematological malignancies. The anti-cancer effects induced by IFN result from a combination of 1) direct cancer cell growth inhibition by cell cycle arrest, apoptosis, or differentiation and 2) the activation of the immune system involving antigen presentation by Clec9A+ dendritic cells and priming of cytotoxic CD8+ T-cells. However, IFN therapy experienced variable and unpredictable success in the clinic. Its clinical application is severely impeded by a complex pattern of adverse side-effects, due to the multifaceted activity pattern of IFN. Therefore, safe exploitation of the anti-cancer potential of IFN requires strategies to direct their activity to selected target cells, avoiding systemic toxicity. Aims Safe exploitation of the anti-cancer potential of IFN requires strategies to direct their activity to selected target cells, avoiding systemic toxicity. Methods To improve the therapeutic index of IFN, we have developed AcTaferons (Activity-on-Target Interferon), optimized (mutant) immunocytokines. Mutated IFNa2Q124R, with a strongly reduced affinity for its receptor complex, was fused to single domain antibodies targeting cell-specific domains, which selectively restores the AcTaferon (AFN) activity in a cell-type specific manner. As such, CD8-AFN and Clec9A-AFN were generated which selectively target either CD8+ T(-ALL) cells or Clec9A+ dendritic cells. Results Using CD8- and CD8+ mouse T-ALL cell lines, we evaluated the direct and indirect anti-leukemic effects of our novel AFNs, in vitro and in vivo upon transplantation in immunocompromised and immunocompetent syngeneic hosts. A significant reduction in the leukemic burden was observed. These anti-cancer effects of AFN were similar as observed for the wildtype IFN, but in a cell-type specific manner and with drastically reduced adverse side-effects. Monotherapy was even sufficient to completely cure a proportion of leukemic mice, which highlights the strong anti-leukemic power of these optimized immunocytokines. Strinkingly only the direct effect CD8-AFN on in vivo CD8+ T-ALL was synergistic with asparaginase treatment. No synergism was observed between asparaginase and the indirect immune-mediated Clec9A-AFN anti-leukemic effect. Conclusion In conclusion, we have developed novel optimized immunocytokines as an off-the-shelve targeted immunotherapy for T-ALL.
Benchmarking Conductivity Predictions of the Advanced Electrolyte Model (AEM) for Aqueous Systems (2019)

High-concentration aqueous electrolytes have shown promise as candidates for a safer, lower-cost battery system. Ionic conductivity is a key property required in high performing electrolytes; the Advanced Electrolyte Model (AEM) has previously shown great accuracy in predicting ionic conductivity in highly-concentrated non-aqueous electrolytes. This work provides extensive experimental data for mixed and highly concentrated aqueous electrolyte systems, rapidly generated via a robotic electrolyte testing apparatus. These data demonstrate exceptional accuracy from AEM in predicting conductivity in aqueous systems, with the accuracy being maintained even in highly-concentrated and mixed-salt regimes.
Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. (2017)

Live imaging modalities facilitate real-time and nondestructive imaging of retinal organoids as they organize into lamellar structures. FLIM and HSpec enable rapid detection of lamellar structure and photoreceptor metabolism. Live imaging techniques may aid in the continuous evaluation of retinal organoid development in diverse experimental and cell therapy settings.
Antimicrobial Prophylaxis and Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology Clinical Practice Guideline (2013)

Antibacterial and antifungal prophylaxis are only recommended for patients expected to have < 100 neutrophils/μL for > 7 days, unless other factors increase risks for complications or mortality to similar levels. Inpatient treatment is standard to manage febrile neutropenic episodes, although carefully selected patients may be managed as outpatients after systematic assessment beginning with a validated risk index (eg, Multinational Association for Supportive Care in Cancer [MASCC] score or Talcott's rules). Patients with MASCC scores ≥ 21 or in Talcott group 4, and without other risk factors, can be managed safely as outpatients. Febrile neutropenic patients should receive initial doses of empirical antibacterial therapy within an hour of triage and should either be monitored for at least 4 hours to determine suitability for outpatient management or be admitted to the hospital. An oral fluoroquinolone plus amoxicillin/clavulanate (or plus clindamycin if penicillin allergic) is recommended as empiric therapy, unless fluoroquinolone prophylaxis was used before fever developed.
3B1322 Crystal structure of the bacterial tRNA(m^1G37)-methyltransferase in complex with a substrate tRNA and a methyl donor analog(3B Nucleic acid binding proteins,The 49th Annual Meeting of the Biophysical Society of Japan) (2011)

TheBiophysicalSociety of Japan General IncorporatedAssociation citrate synthase and Acety1 CoA, [n this system, the ratio ef the concentration of Acetyl CoA and NADH, 5/1 mixtuTe of Acety] CoA and NADH, was significantly important for maintaining the NADH concentration.In this condition, Ranian lines derived from FMN was decreased te -80 Y3, The positive Raman Iines were also appeured ill the lowcr frequeney ofthe redox difi'erence Raman spcctrum.
Recent Developments in Transition Metal-Catalyzed Polymerization I. Polymerization of Olefins by Tebbe-Type Ti(III) Complex/Methylaluminoxane Catalyst. (2002)

Cp2Ti (μ-C1) 2AIXY (X, Y=Cl, Et) で表される3価Tebbe型チタノセン錯体とメチルアルミノキサン (MAO) を組み合わせた触媒系によりエチレンおよびプロピレンの重合を行った. これらの重合においては, Tebbe型錯体中にアルキル基を含まないもの, またAIMe3を除去したメチルアルミノキサン (MAO) を用いた場合に高い活性を示した. また, プロピレン重合においては異種結合を多く含むポリマーが生成した.
Effect of heat and moisture transfer properties on microclimate and subjective thermal comfort of caps (2010)

The purpose of this research is to explore the effect of textile properties on the microclimate inside the cap and subjective wearing sensations in various environmental conditions, with/without radiation or air current. Heat and moisture transfer properties of cap fabrics were measured and their relationships with the microclimate inside caps and with the subjective wearing sensations in three different environmental conditions were analyzed. Principal component analysis and regression analysis were employed for the relationship of microclimatic temperature and thermal comfort. The most important fabric properties affecting the cap microclimate in a hot environment was found to be those related to liquid moisture transport and emission. Properties related to vapor transport and air permeability did not affect the microclimate much in a hot environment without radiation or air current. However, in the radiation environment, fabric with high thermal resistance generated a microclimate with low temperature and humidity, thereby giving good thermal comfort. In the environment with air current, air permeability and its related properties were the most critical fabric properties influencing the microclimate and subjective thermal comfort. According to the regression models obtained, thermal discomfort sensation starts at around 33°C, and becomes very high at 35°C.
Effect of tumor growth factor-beta on NK receptor expression by allostimulated CD8+ T lymphocytes. (1999)

We have examined the influence of the immunosuppressive cytokine TGF-beta on NK receptor expression by T lymphocytes upon allogeneic activation. Using the primary mixed lymphocyte reaction (MLR), our data show that allostimulation induced the expression of CD94/NKG2-A on alloactivated CD8+ T cells. This expression was increased in the presence of TGF-beta whereas IL-15 had no significant effect. The blockage of CD94 and NKG2-A resulted in increased lysis of targets by alloactivated cytotoxic T cells. This increase was dependent on the activation state of T cells. Using PCR, we also demonstrated that TGF-beta had no effect on the transcription of non-inhibitory NKG2 molecules. The present results show that allostimulation can induce CD94 and further point out the role of TGF-beta in the induction of the CD94/NKG2-A receptor on alloactivated T cells.
Metal-insulator transitions in IZO, IGZO, and ITZO films (2014)

In this study, we measured the low-temperature resistivity of amorphous two- and three-dimensional (2D and 3D) indium-zinc oxide, indium-gallium-zinc oxide, and indium-tin-zinc oxide films with a wide range of carrier densities. To determine their critical characteristics at the metal-insulator transition (MIT), we used the Ioffe–Regel criterion. We found that the MIT occurs in a narrow range between kFℓ = 0.13 and kFℓ = 0.25, where kF and ℓ are the Fermi wave number and electron mean free path, respectively. For films in the insulating region, we analyzed ρ(T) using a procedure proposed by Zabrodskii and Zinov'eva. This analysis confirmed the occurrence of Mott and Efros–Shklovskii (ES) variable-range hopping. The materials studied show crossover behavior from exp(TMott/T)1/4 or exp(TMott/T)1/3 for Mott hopping conduction to exp(TES/T)1/2 for ES hopping conduction with decreasing temperature. For both 2D and 3D materials, we found that the relationship between TMott and TES satisfies TES ∝ TMott2/3.
Automated Parallel Solid-Phase Synthesis of Non-Peptide CCR1 Receptor Antagonists (2002)

An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (K(i) < 100 nM).
Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in theBBS4Gene (2005)

Recent discoveries have lead to the hypothesis that ciliary dysfunction is a mechanism underlying the pathogenesis of Bardet-Biedl syndrome (BBS). Here, we describe two individuals with decreased olfaction who are members of an extended family affected with BBS caused by a homozygous deletion (c.77-220del) in the BBS4 gene. These findings correlate with the evidence that several BBS proteins, including BBS4, are expressed in the olfactory epithelium (OE). Although the prevalence and the spectrum of impaired olfaction in BBS are not known, the causal relationship of the BBS4 deletion in this family and the decreased olfaction is corroborated by evidence that Bbs2 and Bbs4 knockout mice have severe olfaction deficits and that also patients with BBS caused by mutations in other BBS genes can have impaired olfaction. This finding broadens the spectrum of clinical manifestations associated with BBS, confirms the role of BBS4 in olfaction, and lends support to the hypothesis that ciliary dysfunction is an important aspect of BBS pathogenesis.
PaceMaker: When ZooKeeper Arteries Get Clogged in Storm Clusters (2016)

As the use of Apache Storm, a distributed real-time computation platform, becomes more widespread in community, scalability of the platform has become a key challenge. Currently, Apache Storm leverages Apache Zookeeper as a message broker for heartbeats and metrics. Using Apache Zookeeper in this manner may have been a good implementation choice at the inception of Apache Storm since it leverages the use of an existing proven open source technology instead of having to implement a proprietary message broker for Storm. However, using Apache Zookeeper in such a fashion has created one of the biggest bottlenecks in scaling Storm. In this paper, we first explore the key scalability issues that this architecture was creating as cluster and workload sizes grow at Yahoo. Next, we discuss in detail a new heartbeat and metrics service, called PaceMaker to address this scalability problem. Finally, we present experimental results to demonstrate that PaceMaker greatly relieves the workload and resource pressure on the ZooKeeper nodes which enables Storm to scale much further.
Supplemental Methods-References-Tables from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells (2023)

&lt;p&gt;Detailed supplemental methods and key references are provided. Tables S1-S2-S3-S4 provide antibody information, mouse study design information, PCR primer information, and an abbreviations list, respectively.&lt;/p&gt;
Figure S3(A-C) from Dual Targeting of EGFR and IGF1R in the TNFAIP8 Knockdown Non–Small Cell Lung Cancer Cells (2023)

&lt;p&gt;Increased expression of SNX1&lt;/p&gt;
Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Supplementary Table S4 from The Pharmacokinetic–Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST (2023)

&lt;p&gt;PKPD data utilized to establish the level and duration of target inhibition required for AZD3229&lt;/p&gt;
Suppressing aflatoxin biosynthesis is not a breakthrough if not useful (2017)

Liver-affecting, carcinogenic aflatoxins produced by Aspergillus spp. are a major problem, especially in the humid developing world where storage conditions are often optimal for the fungi. Peanuts and maize have been transformed with RNAi constructs targeting Aspergillus flavus polyketide-synthase, an early key enzyme in aflatoxin biosynthesis. Aflatoxin biosynthesis was suppressed in developing immature grain, less so in late maturing grain, and it is doubtful that the technology will be effective in near dry mature grain. The infected grain was still mouldy. As Aspergillus that infects grain preharvest can continue to grow and produce aflatoxin in poorly stored grain, and grain storage insects vector further infections, this technology seems to have little potential utility in the humid tropics. The biotechnological approaches of RNAi directly targeting Aspergillus, coupled with transgenic insecticidal proteins should be far more effective. These biotechnological approaches can be used in tandem with the RNAi against polyketide-synthase, as well as with irradiation, biocontrol and better grain drying and hermetic dry storage in a controlled atmosphere. © 2017 Society of Chemical Industry.
Role of antineutrophil cytoplasmic antibodies in an ethnically distinct population: Korean patients with ulcerative colitis. (1995)

High sensitivity and specificity of ANCA in an ethnically distinct group of patients with UC show that ANCA expression may not be ethnically determined, and they confirm the utility of ANCA as a useful diagnostic indicator of UC in an ethnically diverse groups of patients.
Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance (2013)

These findings show that jejunal proteins either from db/db mice or from insulin resistant subjects impair muscle insulin signaling, thus inducing insulin resistance.
Influence of temperature on the magnetic properties of electroplated Co-rich Co–Pt thick films (2013)

In this paper, the magnetic properties of 10 µm thick Co-rich Co–Pt films (~80:20 atomic ratio) hard magnetic films electroplated on silicon substrates are characterized at temperatures from 300 to 1000 K. With an increase in temperature up to 500 K, the coercivity and remanence of the films both decrease rapidly, dropping to only 10% of their respective as-deposited values. Above 500 K, the coercivity and remanence continue declining but at a slower rate, reaching nearly zero at 1000 K. Conversely, the saturation magnetization reduces by only 15% at 800 K and 40% at 1000 K from the as-deposited value. In addition to these measurements at elevated temperature measurements, thermal cycling tests are performed to examine the influence of various thermal exposures. Cycles up to 500 K are shown to have little impact on the film morphology but notably reduce the layer adhesion. Most importantly, a thermal cycle to just 400 K is shown to essentially destroy the hard magnetic properties. Because of these temperature sensitivities, Co-rich Co–Pt films may be significantly limited for end applications.
Timing of the endometrial biopsy may be critical for the accurate diagnosis of luteal phase deficiency (1994)

Our findings indicate that an endometrial biopsy performed in the midluteal phase may detect a greater number of women with delayed endometrial maturation during the temporal window of embryo implantation. The observation that most of the women with out-of-phase midluteal biopsies had normal late luteal endometrium may represent a cryptic form of luteal phase deficiency.
Deep Graphics Encoder for Real-Time Video Makeup Synthesis from Example (2021)

International audience
Identification of a Synthetic Polyhydroxyphenolic Resveratrol Analogue, 3,3′,4,4′,5,5′-Hexahydroxy-trans-Stilbene with Anti-SARS-CoV-2 Activity (2023)

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has been causing the COVID-19 pandemic since December 2019, with over 600 million infected persons worldwide and over six million deaths. We investigated the anti-viral effects of polyphenolic green tea ingredients and the synthetic resveratrol analogue 3,3',4,4',5,5'-hexahydroxy-<i>trans</i>-stilbene (<b>HHS</b>), a compound with antioxidant, antitumor and anti-HIV properties. In the TCID<sub>50</sub> assay, four out of nine green tea constituents showed minor to modest cell protective effects, whereas HHS demonstrated the highest reduction (1103-fold) of the TCID<sub>50</sub>, indicating pronounced inhibition of virus replication. <b>HHS</b> was also a highly effective inhibitor of SARS-CoV-2 proliferation in VeroE6 cells with an IC<sub>50</sub> value of 31.1 µM. <b>HSS</b> also inhibited the binding of the receptor-binding domain (RBD) of the spike protein to the human angiotensin-converting enzyme 2 (ACE2) receptor (RBD-ACE2) binding with 29% at 100 µM and with 9.2% at 50 µM indicating that the SARS-CoV-2 inhibitory effect might at least in part be attributed to the inhibition of virus binding to ACE2. Based on the chemical similarity to other polyphenols, the oral bioavailability of <b>HHS</b> is likely also very low, resulting in blood levels far below the inhibitory concentration of <b>EGCG</b> against SARS-CoV-2 observed in vitro. However, administration of <b>HHS</b> topically as a nose or throat spray would increase concentrations several-fold above the minimal inhibitory concentration (MIC) in the mucosa and might reduce virus load when administered soon after infection. Due to these promising tissue culture results, further preclinical and clinical studies are warranted to develop <b>HHS</b> as an additional treatment option for SARS-CoV-2 infection to complement vaccines, which is and will be the main pillar to combat the COVID-19 pandemic.
Benzothiadiazole- and pyrrole-based polymers bearing thermally cleavable solubilizing groups as precursors for low bandgap polymers (2006)

We report the design, synthesis and characterization of new benzothiadiazole- and pyrrole-based copolymers whose solubility and bandgap drastically change after thermal treatment of their thin films.
Enhancing the Infrared Photoresponse of Silicon by Controlling the Fermi Level Location within an Impurity Band (2014)

Strong absorption of sub‐band gap radiation by an impurity band has recently been demonstrated in silicon supersaturated with chalcogen impurities. However, despite the enhanced absorption in this material, the transformation of infrared radiation into an electrical signal via extrinsic photoconductivity—the critical performance requirement for many optoelectronic applications—has only been reported at low temperature because thermal impurity ionization overwhelms photoionization at room temperature. Here, dopant compensation is used to manipulate the optical and electronic properties and thereby improve the room‐temperature infrared photoresponse. Silicon co‐doped with boron and sulfur is fabricated using ion implantation and nanosecond pulsed laser melting to achieve supersaturated sulfur concentrations and a matched boron distribution. The location of the Fermi level within the sulfur‐induced impurity band is controlled by tuning the acceptor‐to‐donor ratio, and through this dopant compensation, three orders of magnitude improvement in infrared detection at 1550 nm is demonstrated.
Quantifying the sustainability impact of Google Maps: A case study of Salt Lake City (2021)

Google Maps uses current and historical traffic trends to provide routes to drivers. In this paper, we use microscopic traffic simulation to quantify the improvements to both travel time and CO$_2$ emissions from Google Maps real-time navigation. A case study in Salt Lake City shows that Google Maps users are, on average, saving 1.7% of CO$_2$ emissions and 6.5% travel time. If we restrict to the users for which Google Maps finds a different route than their original route, the average savings are 3.4% of CO$_2$ emissions and 12.5% of travel time. These results are based on traffic conditions observed during the Covid-19 pandemic. As congestion gradually builds back up to pre-pandemic levels, it is expected to lead to even greater savings in emissions.
Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma (2021)

Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14<sup>pos</sup> CD16<sup>neg</sup>) and intermediate- (iMO, CD14<sup>pos</sup> CD16<sup>pos</sup>) monocytes accumulated in DLBCL peripheral blood and exhibited an inflammatory phenotype. On the opposite, nonclassical monocytes (ncMOSlan<sup>pos</sup>, CD14<sup>low</sup> CD16<sup>pos</sup> Slan<sup>neg</sup> and ncMOSlan<sup>neg</sup>, CD14<sup>low</sup> CD16<sup>pos</sup>, Slan<sup>neg</sup>) were decreased in peripheral blood. Tumor-conditioned monocytes presented similarities with ncMO phenotype from DLBCL and were prone to migrate in response to CCL5 and CXCL12, and presented similarities with DLBCL-infiltrated myeloid cells, as defined by mass cytometry. Finally, we demonstrated the adverse value of an accumulation of nonclassical monocytes in 2 independent cohorts of DLBCL.