gebhart/patrepeval huggingface dataset:
Gas Flow Monitoring in High and Low Reynolds Regimes Based on Compensated FMCW-Radar Phase Measurements (2016)

Abstract In this contribution, a composite measurement concept for the gas flow determination in diverse stream scenarios is presented. The approach utilizes the pressure- and mixing-dependent relative permittivity of gaseous media, which, in case of a vortex or a marker gas, creates a detectable variation in the measuring beam of the radar. Since the measurement effect is very small, phase measurements based on highly precise and low jitter frequency-modulated continuous-wave radar systems in different frequency bands are applied. Moreover, disturbances caused by vibrations of the measurement setup are compensated out of the measurement signal.
An Advanced Hardware Platform to Verify 5G Wireless Communication Concepts (2015)

Verification of first 5G concepts of a new air interface with real hardware prototypes is challenging. In this paper, we highlight a flexible software-defined radio (SDR) platform which can be used to implement novel 5G communication concepts. The proposed software and hardware architecture was previously used to implement early LTE-Advanced features, e.g. flexible multiband carrier-aggregation (CA). Furthermore, the prototype was used for transmission experiments of new multi carrier waveforms. The proposed setup allows early proof-of-concepts (PoC) by extending hardware-in-the-loop (HILO) experiments to small laboratory experiments and finally real outdoor test trials of a novel 5G air interface and concepts.
The natural product argentatin C attenuates postoperative pain via inhibition of voltage‐gated sodium and T‐type voltage‐gated calcium channels (2022)

These results suggest that the dual effect of argentatin C on voltage-gated sodium and calcium channels supports its potential as a novel treatment for painful conditions.
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay (1986)

A series of 60 newly synthesized and known quinolone antibacterials, including quinoline- and 1,8-naphthyridine-3-carboxylic acids, pyrido[2,3-d]pyrimidine-6-carboxylic acids, and some monocyclic 4-pyridone-3-carboxylic acids, were tested and compared in a newly established, easy to perform, DNA gyrase assay. The results were correlated with minimum inhibitory concentrations (MICs) against a variety of organisms. Among the known quinolones were 14 clinically significant drugs (oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, etc.) which were used as standards and compared side-by-side. The study focused on the changes in DNA gyrase inhibition brought about by certain features of the molecules, namely, the C6-fluorine or the nature of the C7 substituent. The intrinsic gyrase inhibition of the fused parent rings, quinoline vs. naphthyridine vs. pyrido[2,3-d]pyrimidine, was also explored. In all cases, loss of enzyme inhibition produced poor MICs, but some compounds with good DNA gyrase inhibition did not correspondingly inhibit bacterial growth. Possible explanations for this phenomena and the benefits of a DNA gyrase-MIC strategy for developing future structure-activity relationships are discussed.
The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface (2018)

This study was sponsored by Mitotech SA Pharmaceuticals.
ChemInform Abstract: PD 165929 ‐ The First High Affinity Non‐Peptide Neuromedin‐B (NMB) Receptor Selective Antagonist. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Unique, Real Internal Rate of Return: Caveat Emptor! (1978)

The purpose of this paper is to show that the internal rate of return (IRR) even when unique and real may nevertheless be an incorrect measure of the return on investment, and to prove that all projects characterized by negative flows occurring only at the beginning and end will be mixed investments for which the IRR, whether unique and real or not, is not a correct measure of investment return.
Location-Based Message Aggregation in Vehicular Ad Hoc Networks (2007)

In vehicular ad hoc networks, vehicles cooperate in receiving and delivering messages to each other in ad hoc manner without the need for an expensive fixed infrastructure. Nevertheless, inter-vehicle communications require solving the problem of message routing, where the location of the destination node is unknown due to node mobility and lack of adequate infrastructure. Hence, the problem of finding the location of the destination node (node localization) becomes very complex. One of the most recent solution approaches for node localization in VANET is to use location service management protocols. However, major impediments in leveraging such promising solutions include the large volume of signaling overhead which results from the increase in the number of vehicles and/or the non-local communication traffic in the network. In this paper, a region-based location service management protocol (RLSMP) is proposed. This protocol is a self-organizing framework, which uses message aggregation enhanced by geographical clustering to minimize the volume of the signaling overhead. RLSMP is the first protocol that uses message aggregation in querying, and promises scalability, locality awareness, minimum signaling overhead and maximum channel utilization.
Liquid Cooling for Thermal Management of Data Centers (2008)

The power trend for Server systems continues to grow thereby making thermal management of Data centers a very challenging task. Although various configurations exist, the raised floor plenum with Computer Room Air Conditioners (CRACs) providing cold air is a popular operating strategy. The air cooling of data center however, may not address the situation where more energy is expended in cooling infrastructure than the thermal load of data center. Revised power trend projections by ASHRAE TC 9.9 predict heat load as high as 5000W per square feet of compute servers’ equipment footprint by year 2010. These trend charts also indicate that heat load per product footprint has doubled for storage servers during 2000–2004. For the same period, heat load per product footprint for compute servers has tripled. Amongst the systems that are currently available and being shipped, many racks exceed 20kW. Such high heat loads have raised concerns over limits of air cooling of data centers similar to air cooling of microprocessors. Thermal management of such dense data center clusters using liquid cooling is presented.
A constrained asymmetry LMS algorithm for PRML disk drive read channels (2001)

We present an implementation of a constrained least mean square (C-LMS) algorithm with application to high-speed magnetic disk drive read channels. The main advantage offered by the presented C-LMS algorithm is improved stability of the outer timing recovery loop while the spectral shaping of read-back data is performed in the inner adaptation loop. This eliminates any unstable behavior of the timing recovery loop during C-LMS algorithm adaptation. Another benefit derived from this approach is reduction in coefficient switching gradient noise. The proposed algorithm has been implemented and fabricated in a commercial read channel using a 0.18 /spl mu/m L-effective CMOS technology. It operates at 550 MHz worst case.
Ambiguity functions, processing gains, and Cramer-Rao bounds for matched illumination radar signals (2015)

Ambiguity functions (AFs) are obtained for a radar using matched illumination (MI) transmit signals for the detection of range-spread targets in the presence of clutter. The transmit signals are adapted to target and interference spectra and are filtered optimally in the receiver; they are designed to maximize signal-to-interference-and-noise ratio (SINR) power ratios at receiver output. In this paper, expressions for processing gains, spread AFs, and Cramer-Rao bounds on range and Doppler estimates are derived based on likelihood functions. Here, for extended targets, AFs resulting from using optimal MI constant envelope waveforms obtained via phase retrieval techniques demonstrate superior resolution characteristics compared with classic linear frequency-modulated (LFM) signals employing optimal pulse compression. For various target and clutter spectral models, simulation results show that optimally filtered MI signals provide significantly enhanced SINR behavior compared with LFM radar signals. Hopefully, these results set the stage for the induction of MI signaling and receive techniques into conventional radar signal processing and pave the way for realization of one methodology for achieving cognition in radar systems.
Long-Term Administration of Estradiol Decreases Expression of Hepatic Lipogenic Genes and Improves Insulin Sensitivity in ob/ob Mice: A Possible Mechanism Is through Direct Regulation of Signal Transducer and Activator of Transcription 3 (2006)

In this study, we used ob/ob mice as a model to investigate the effects of long-term estradiol administration on insulin sensitivity and to explore the mechanisms that underlie the antidiabetic effects of estrogen on mouse liver. Female ob/ob mice were randomly divided into two groups and given estradiol (100 μg/kg·d) or vehicle alone for 4 wk. Estrogen administration improved glucose tolerance and insulin response to glucose in ob/ob mice. Moreover, insulin resistance and liver triglyceride levels were decreased in response to estrogen administration. Microarray analysis revealed that expression of genes involved in hepatic lipid biosynthesis was decreased in ob/ob mouse livers after estradiol treatment. Further searches for direct estrogen target genes revealed increased hepatic mRNA expression of signal transducer and activator of transcription 3 (Stat3) and several known Stat3 target genes in ob/ob livers after long-term estradiol treatment. Furthermore, Stat3 and phosphorylated Stat3 protein is induced in ob/ob mouse liver after long-term estrogen treatment. We also present data showing that Stat3 is rapidly induced by estradiol in mouse livers. This, together with data showing recruitment of ERα to the promoter of Stat3 in vivo, suggests that Stat3 is a direct target gene for estradiol. In conclusion, estradiol treatment improves glucose tolerance and insulin sensitivity in ob/ob mice. We propose that this may be mediated, at least partially, via estrogen stimulation of the hepatic expression of Stat3, leading to decreased expression of hepatic lipogenic genes, and thereby to antidiabetic effects.
Giving a voice to adults with COVID-19: An analysis of open-ended comments from smell longhaulers and non-longhaulers (2023)

Abstract Smell disorders are commonly reported with COVID-19 infection. Some patients show prolonged smell-related issues, even after the respiratory symptoms are resolved. To explore the concerns of patients, and to provide an overview for each specific smell disorder, we explored the longitudinal survey that was conducted by 1 , and contained self-reports on the changes of smell that participants experienced at two time points. People who still suffered from smell disorders at the second time point, hence named ‘longhaulers’, were compared to those who were not, hence named ‘non-longhaulers’. Specifically, three aims were pursued in this study. First, to classify smell disorders based on the participants’ self-reports. Second, to classify the sentiment of each self-report using a machine learning approach, and third, to find specific keywords that best describe the smell dysfunction in those self-reports. We found that the prevalence of parosmia and hyposmia was higher in longhaulers than in non-longhaulers. Furthermore, the results suggest that longhaulers stated self-reports with more negative sentiment than non-longhaulers. Finally, we found specific keywords that were more typical for either longhaulers compared to non-longhaulers. Taken together, our work shows consistent findings with previous studies, while at the same time, provides new insights for future studies investigating smell disorders.
Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo (2020)

Effective vaccine delivery and coverage to rural and resource-poor countries is hindered by the dependence on cold chain storage. As such, developments of cold chain-free technologies are highly sought. Although spray dried adenoviral vectors have shown long term stability at ambient temperatures and relatively low humidity, it remains to be determined whether similar excipient formulations are applicable to other viral vectors. To address this, we have spray dried vesicular stomatitis virus (VSV)-vectors with a panel of well-characterized sugar excipients to determine the optimal formulation for vector stabilization. Upon reconstitution, we show that trehalose conferred superior stability of VSV both in vitro and in vivo. Importantly, following cold chain-free storage at elevated temperatures at 37 °C for 15 days, we show that a VSV-vectored vaccine retains its in vivo immunogenicity, whereas a liquid control completely lost its immune-stimulating ability. Our results provide foundational evidence that spray drying with properly tested excipients can stabilize viral vectors such as VSV, allowing them to be stored long-term at elevated temperatures without dependency on cold chain conditions.
Genome‑based vaccine development: A short cut for the future (2008)

Bacterial infectious diseases remain a major cause of deaths and disabilities in the world. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed in providing efficient vaccines against many others. Together to the sequencing of the first genome, a new chapter in the vaccinology history started to be written. Reverse vaccinology changed the way to think about vaccine development, using the information provided by the microorganisms' genome against themselves. Since then, reverse vaccinology has evolved and helped researchers to overcome the limits of the conventional vaccinology approaches and led to the discovery and development of novel vaccines concerning emerging diseases, like Neisseria meningitidis B and Streptococcus agalactiae. A lot of work must be done, but deciphering the information provided by genome sequences and using it to better understand the host-pathogen interactions has proved to be the key for protection.
Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants (2020)

This work provides a framework able to track down SARS-CoV-2 genomic variability.
OPC model generation procedure for different reticle vendors (2003)

The challenge of delivering acceptable semiconductor products to customers in timely fashion becomes more difficult as design complexity increases. The requirements of current generation designs tax OPC engineers greater than ever before since the readiness of high-quality OPC models can delay new process qualifications or lead to respins, which add to the upward-spiraling costs of new reticle sets, extend time-to-market, and disappoint customers. In their efforts to extend the printability of new designs, OPC engineers generally focus on the data-to-wafer path, ignoring data-to-mask effects almost entirely. However, it is unknown whether reticle makers' disparate processes truly yield comparable reticles, even with identical tools. This approach raises the question of whether a single OPC model is applicable to all reticle vendors. LSI Logic has developed a methodology for quantifying vendor-to-vendor reticle manufacturing differences and adapting OPC models for use at several reticle vendors. This approach allows LSI Logic to easily adapt existing OPC models for use with several reticle vendors and obviates the generation of unnecessary models, allowing OPC engineers to focus their efforts on the most critical layers.
Supplemental Figure S5 from MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies (2023)

&lt;p&gt;MGD011 inhibited tumor dissemination and improved survival in a disseminated leukemia/lymphoma model in humanized mice&lt;/p&gt;
Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells (2014)

Apoptosis is coupled with recruitment of macrophages for engulfment of dead cells, and with compensatory proliferation of neighboring cells. Yet, this death process is silent, and it does not cause inflammation. The molecular mechanisms underlying anti-inflammatory nature of the apoptotic process remains poorly understood. In this study, we found that the culture supernatant of apoptotic cells activated the macrophages to express anti-inflammatory genes such as Nr4a and Thbs1. A high level of AMP accumulated in the apoptotic cell supernatant in a Pannexin1-dependent manner. A nucleotidase inhibitor and A2a adenosine receptor antagonist inhibited the apoptotic supernatant-induced gene expression, suggesting AMP was metabolized to adenosine by an ecto-5'-nucleotidase expressed on macrophages, to activate the macrophage A2a adenosine receptor. Intraperitoneal injection of zymosan into Adora2a- or Panx1-deficient mice produced high, sustained levels of inflammatory mediators in the peritoneal lavage. These results indicated that AMP from apoptotic cells suppresses inflammation as a 'calm down' signal. DOI: http://dx.doi.org/10.7554/eLife.02172.001.
Analysis of Nonlinear Torsional Dynamics Using Second-Order Solutions (2010)

Based on the modal series method, this paper derives the second- and first-order solutions of torques for investigating nonlinear torsional dynamics. The derivatives of the two types of solutions are compared to explain the advantage of the second-order solutions. The index is given for evaluating the feasibility of solutions. Subsequently, several nonlinearity indices are defined to quantify the effects of nonlinear modal interactions on torsional dynamics, and the suitable indices are determined for analyzing nonlinear torsional dynamics. The systematic method is developed for the analysis of nonlinear torsional dynamics. Furthermore, the concept of nonlinear modal interactions is extended to deal with both the fundamental and the combination modes; the nonlinearity contribution factors are emphasized. The study is implemented on two modified cases from the IEEE first benchmark model, which validates the presented method for investigating torsional dynamics in the stressed case and gives new engineering insights into nonlinear torsional dynamics.
An advanced RFID system to avoid collision of RFID reader, using channel holder and dual sensitivities (2007)

Abstract Recently, RFID system has become popular and has been growing rapidly. Due to using many readers in limited area, RFID reader collision problem occurs when the reader is interfered with the signals from neighbor readers or other devices. Even if 50 channels are available in North America, 15 channels in Europe and 25 channels in Korea are available. Moreover, in the future, if many mobile (cellular) RFID readers might be used in limited area simultaneously, the number of channels is not enough, and the collision problem might be more serious. Therefore, this paper proposes an advanced RFID system with a channel holder and dual reader sensitivities/reduced reader output power. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2643–2647, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22808
The HD‐ZIP IV transcription factor OCL4 is necessary for trichome patterning and anther development in maize (2009)

Among the genes controlling the differentiation and maintenance of epidermal cell fate are members of the HD-ZIP IV class family of plant-specific transcription factors, most of which are specifically expressed in the epidermis of tissues. Here, we report the functional analysis of the maize HD-ZIP IV gene OCL4 (outer cell layer 4) via the phenotypic analysis of two insertional mutants, and of OCL4-RNAi transgenic plants. In all three materials, the macrohairs, one of the three types of trichomes present on adult maize leaf blades, developed ectopically at the margin of juvenile and adult leaves. Consistent with this phenotype, OCL4 is expressed in the epidermis of the leaf blade, with a maximum at the margin of young leaf primordia. Expression of OCL4 in the model plant Arabidopsis under the control of the GLABRA2 (GL2) promoter, a member of the Arabidopsis HD-ZIP IV family involved in trichome differentiation, did not complement the gl2-1 mutant, but instead aggravated its phenotype. The construct also caused a glabrous appearance of rosette leaves in transformed control plants of the Ler ecotype, suggesting that OCL4 inhibits trichome development both in maize and Arabidopsis. Furthermore, insertional mutants showed a partial male sterility that is likely to result from the presence of an extra subepidermal cell layer with endothecium characteristics in the anther wall. Interestingly, the epidermis-specific OCL4 expression in immature anthers was restricted to the region of the anther locule where the extra cell layer differentiated. Taken together these results suggest that OCL4 inhibits trichome development and influences division and/or differentiation of the anther cell wall.
Pomare project, first results on marine invertebrates quorum sensing inhibitors (2014)

International audience
Genetic control of epithelial tube fusion during Drosophila tracheal development (1996)

During development of tubular networks such as the mammalian vascular system, the kidney and the Drosophila tracheal system, epithelial tubes must fuse to each other to form a continuous network. Little is known of the cellular mechanisms or molecular control of epithelial tube fusion. We describe the cellular dynamics of a tracheal fusion event in Drosophila and identify a gene regulatory hierarchy that controls this extraordinary process. A tracheal cell located at the developing fusion point expresses a sequence of specific markers as it grows out and contacts a similar cell from another tube; the two cells adhere and form an intercellular junction, and they become doughnut-shaped cells with the lumen passing through them. The early fusion marker Fusion-1 is identified as the escargot gene. It lies near the top of the regulatory hierarchy, activating the expression of later fusion markers and repressing genes that promote branching. Ectopic expression of escargot activates the fusion process and suppresses branching throughout the tracheal system, leading to ectopic tracheal connections that resemble certain arteriovenous malformations in humans. This establishes a simple genetic system to study fusion of epithelial tubes.
ChemInform Abstract: Synthesis and HIV‐1 Reverse Transcriptase Inhibition Properties of Two New Methylenephosphonate Analogues of 3′‐Azido‐3′‐deoxythymidine‐5′‐ triphosphate. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.