gebhart/patrepeval huggingface dataset:
Compact inductor-capacitor resonators at sub-gigahertz frequencies (2023)

Compact inductor-capacitor (LC) resonators, in contrast to coplanar waveguide (CPW) resonators, have a simple lumped-element circuit representation but usually call for sophisticated finite-element method (FEM) simulations for an accurate modelling. Here we present an simple analytical model for a family of coplanar LC resonators where the electrical properties are directly obtained from the circuit geometry with a satisfying accuracy. Our experimental results on $10$ high-internal-quality-factor resonators ($Q_{\rm i}\gtrsim 2\times 10^{5}$), with frequency ranging roughly from $300\,{\rm MHz}$ to $1\,{\rm GHz}$, show an excellent consistency with both the derived analytical model and detailed FEM simulations. These results showcase the ability to design sub-gigahertz resonators with less than $2\%$ deviation in the resonance frequency, which has immediate applications, for example, in the implementation of ultrasensitive cryogenic detectors. The achieved compact resonator size of the order of a square millimeter indicates a feasible way to integrate hundreds of microwave resonators on a single chip for realizing photonic lattices.
Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation (2009)

Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.
Solubilization of Aromatic Solutes in Block Copolymers (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubilization of Aromatic Solutes in Block CopolymersFrederic Gadelle, William J. Koros, and Robert S. SchechterCite this: Macromolecules 1995, 28, 14, 4883–4892Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ma00118a014https://doi.org/10.1021/ma00118a014research-articleACS PublicationsRequest reuse permissionsArticle Views583Altmetric-Citations124LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates (1969)

Patients with acute leukemia were given repeated cycles consisting of infusions of methotrexate followed by "rescue" with folinic acid. Peripheral blood leukemic cells were harvested from patients before cyclical treatment, and the rates of incorporation of thymidine and of deoxyuridine into deoxyribonucleic acid (DNA) were measuared in vitro. There was no relationship between the pretreatment incorporation of either deoxynucleoside into DNA and the clinical response to therapy. Methotrexate suppressed deoxyuridine incorporation into DNA by the leukemic blasts in vitro, but the patients whose cells were most sensitive to this effect did not necessarily go into remission when treated. Leukemic cells were sampled during methotrexate infusions and the deoxynucleoside incorporation rates were determined. Thymidine incorporation into DNA was variably affected. If, by the end of the first infusion, it remained elevated, remission rarely followed, whereas if it was below the pretreatment value, remission was much more likely. In all cases, deoxyuridine incorporation was suppressed during the infusion. The greatest suppression occurred in patients who went on to remission, but the suppression did not correlate with that expected from pretreatment in vitro tests unless due weight was given to the concomitant effects of the methotrexate therapy on thymidine incorporation. Leukemic blasts surviving successive cycles of therapy became progressively more resistant to the suppressing effects of methotrexate in vitro. This resistance became especially marked in the blasts of patients who did not go into remission. During methotrexate infusions, inhibition of leukemic cell dihydrofolate reductase activity was greatest in blasts of patients whose disease subsequently remitted.
Restoration of electrophysiological signals distorted by inductive effects of magnetic field gradients during MR sequences (1999)

A generally applicable method for almost complete suppression of signal artifacts on electrophysiological signals caused by B0-gradient switching (gradient noise) is presented. The method is demonstrated for electrocardiograms (ECGs) but can also be used for other electrophysiological signals. It takes advantage of the fact that under certain conditions, the effect of switching the B0-field gradient upon an electrophysiological signal can be modeled as a linear time-invariant system and fully characterized by pulse response functions. It is shown how the system's pulse response functions of the X, Y, and Z gradients can be determined and how gradient noise can be eliminated efficiently. The elimination of gradient noise by the proposed method causes in the current arrangement a constant delay of 128 msec, which is acceptable for patient monitoring and magnetic resonance sequence triggering.
Performance Metrics and Design Parameters for a Free-space Communication Link Based on Multiplexing of Multiple Orbital-Angular-Momentum Beams (2014)

We study the design parameters for an orbital angular momentum (OAM) multiplexed free-space data link. Power loss, channel crosstalk and power penalty of the link are analyzed in the case of misalignment between the transmitter and receiver (lateral displacement, receiver angular error, or transmitter pointing error). The relationship among the system power loss and link distance, transmitted beam size and receiver aperture size are discussed based on the beam divergence due to free space propagation. We also describe the trade-offs for different receiver aperture sizes and mode spacing of the transmitted OAM beams under given lateral displacements or receiver angular errors. Through simulations and some experiments, we show that (1) a system with a larger transmitted beam size and a larger receiver aperture is more tolerant to the lateral displacement but less tolerant to the receiver angular error; (2) a system with a larger mode spacing, which uses larger OAM charges, suffers more system power loss but less channel crosstalk; thus, a system with a small mode spacing shows lower system power penalty when system power loss dominates (e.g., small lateral displacement or receiver angular error) while that with a larger mode spacing shows lower power penalty when channel crosstalk dominates (e.g., larger lateral displacement or receiver angular error); (3) the effects of lateral displacement and receiver angular error are not necessarily independent; as an example of them combined, the effects of the transmitter pointing error on the system are also investigated.
Spectroscopy and laser properties of Nd sup 3+ -doped CaF sub 2 , SrF sub 2 and BaF sub 2 (1990)

The optical properties of Nd{sup 3+} in CaF{sub 2}, SrF{sub 2}, and BaF{sub 2} have been investigated in order to determine if these materials are useful as laser-pumped amplifier media. The CaF{sub 2}:Nd crystal was found to not be useful because the impurities tend to cluster at very low concentration, leading to the formation of nonluminescent centers. On the other hand, the Nd{sup 3+} centers in BaF{sub 2} exhibit unacceptably low transition strengths. SrF{sub 2}:Nd appears to have adequate absorption strength, and, in addition, to have a remarkably long emission lifetime of 1280 {mu}s. A maximum doping of 0.20 atomic % Nd{sup 3+} can be tolerated in SrF{sub 2} without the occurrence of detrimental clustering. The peak emission cross section of SrF{sub 2}:Nd is 1.7 {times} 10{sup {minus}20} cm{sup 2} at 1036.5 nm. Direct measurement of the gain spectrum of SrF{sub 2}:Nd{sup 3+} reveals the presence of the {sup 4}F{sub 3/2} {r arrow} {sup 2}G{sub 9/2} excited state absorption lines, although the impact on the emission cross section is minor. 19 refs., 7 figs.
Abstract 1750: Human KIT+myeloid cells facilitate visceral organ colonization by melanoma (2021)

Abstract Metastasis is a major risk factor for poor melanoma outcome, but mechanisms supporting distant organ colonization by melanoma are not fully understood. Here, we found that metastatic melanoma tumors from patients are infiltrated by CD33+ myeloid cells. To determine the role of CD33+ cells in melanoma metastasis, we used NSG mice humanized by engraftment of human CD34+ hematopoietic progenitor cells and transgenic expression of human hematopoietic cytokines SCF/GM-CSF/IL-3 (SGM3). Humanized (h)NSG-SGM3 mice enabled development of human CD33+ myeloid cells in the bone marrow and peripheral tissues, and when implanted subcutaneously with human melanoma cell line, supported melanoma colonization of the spleen, liver, lung, and kidneys. Melanoma growth in distant organs was dependent on host SGM3 expression and facilitated by human CD33+ myeloid cells. Deeper characterization attributed this activity to a rare human IL-3- and SCF-dependent CD33+CD11b+CD117+ progenitor cell subset comprising &amp;lt;4% of the total CD45+ leukocyte population. Metastatic tumor-infiltrating CD33+ cells from patients and hNSG-SGM3 mice showed converging transcriptional profiles. Single-cell RNAseq analysis identified a gene signature of a KIT/CD117 expressing CD33+ subset that correlated with decreased overall survival in TCGA melanoma samples. Thus, human CD33+CD11b+CD117+ myeloid cells facilitate metastatic colonization of distant organs by melanoma, representing a novel candidate biomarker as well as a therapeutic opportunity for metastatic melanoma. Citation Format: Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Rick Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K. Oliveira, Victor G. Wang, Jeffrey H. Chuang, Paul Robson, Jacques Banchereau, Karolina Palucka. Human KIT+myeloid cells facilitate visceral organ colonization by melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1750.
Nanofibrillar Patches of Commensal Skin Bacteria (2018)

We demonstrate entrapment of the commensal skin bacteria Staphylococcus epidermidis in mats composed of soft nanotubes made by membrane-templated layer-by-layer (LbL) assembly. When cultured in broth, the resulting nanofibrillar patches efficiently delay the escape of bacteria and their planktonic growth, while displaying high steady-state metabolic activity. Additionally, the material properties and metabolic activity can be further tuned by postprocessing the patches with additional polysaccharide LbL layers. These patches offer a promising methodology for the fabrication of bacterial skin dressings for the treatment of skin dysbiosis while preventing adverse effects due to bacterial proliferation.
Cancer-testis antigen expression and immunogenicity in AL amyloidosis (2012)

Light-chain amyloidosis (AL) is a plasma cell dyscrasia closely related to multiple myeloma. In multiple myeloma, the cancer-testis antigens (CTAs) CT7 (MAGE-C1), CT10 (MAGE-C2) and MAGE-A CTAs are expressed in up to 80% of cases. In this study, we investigated the expression and immunogenicity of several CTAs in patients with AL amyloidosis in a total of 38 bone marrow specimens by employing standard immunohistochemistry techniques on paraffin-embedded archival tissues. Plasma samples from 35 patients (27 with matched bone marrow samples) were also analyzed by ELISA for sero reactivity to a group of full-length CTA proteins. CT7 was present in 25/38 (66%) while CT10 was demonstrated in 3/38 and GAGE in 1/38 AL amyloid cases. The expression pattern was mostly focal. There were no significant differences with regard to organ involvement, response to treatment, or prognosis in CTA positive compared to negative cases. None of the specimens showed spontaneous humoral immunity to CT7, but sero reactivity was observed in individual patients to other CTAs. This study identifies CT7 as the prevalent CTA in plasma cells of patients with AL amyloidosis. Further analyses determining the biology of CTAs in AL amyloidosis and their value as potential targets for immunotherapy are warranted.
Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements. (1999)

In a study involving 10 different sites, independent results of measurements of ultrasonic properties on equivalent tissue-mimicking samples are reported and compared. The properties measured were propagation speed, attenuation coefficients, and backscatter coefficients. Reasonably good agreement exists for attenuation coefficients, but less satisfactory results were found for propagation speeds. As anticipated, agreement was not impressive in the case of backscatter coefficients. Results for four sites agreed rather well in both absolute values and frequency dependence, and results from other sites were lower by as much as an order of magnitude. The study is valuable for laboratories doing quantitative studies.
Soliton walls paired by polar surface interactions in a ferroelectric nematic liquid crystal (2022)

Surface interactions are responsible for many properties of condensed matter, ranging from crystal faceting to the kinetics of phase transitions. Usually, these interactions are polar along the normal to the interface and apolar within the interface. Here we demonstrate that polar in-plane surface interactions of a ferroelectric nematic N<sub>F</sub> produce polar monodomains in micron-thin planar cells and stripes of an alternating electric polarization, separated by [Formula: see text] domain walls, in thicker slabs. The surface polarity binds together pairs of these walls, yielding a total polarization rotation by [Formula: see text]. The polar contribution to the total surface anchoring strength is on the order of 10%. The domain walls involve splay, bend, and twist of the polarization. The structure suggests that the splay elastic constant is larger than the bend modulus. The [Formula: see text] pairs resemble domain walls in cosmology models with biased vacuums and ferromagnets in an external magnetic field.
Percolation network dynamicity and sheet dynamics governed viscous behavior of polydispersed graphene nanosheet suspensions (2013)

The viscosity of polydispersed graphene nanosheet (5 nm-1.5 mu m) suspensions (GNS) and its behavior with temperature and concentration have been experimentally determined. A physical mechanism for the enhanced viscosity over the base fluids has been proposed for the polydispersed GNSs. Experimental data reveal that enhancement of viscosity for GNSs lies in between those of carbon nanotube suspensions (CNTSs) and nano-alumina suspensions, indicating the hybrid mechanism of percolation (like CNTs) and Brownian motion-assisted sheet dynamics (like alumina particles). Sheet dynamics and percolation, along with a proposed percolation network dynamicity factor, have been used to determine a dimensionally consistent analytic model to accurately determine and explain the viscosity of polydispersed GNSs. The model also provides insight into the mechanisms of viscous behavior of different dilute nanoparticle suspensions. The model has been found to be in agreement with the GNS experimental data, and even for CNT (diameter 20 nm, length 10 mu m) and nano-alumina (45 nm) suspensions.
Accurate Measurement of Copper Overload in an Experimental Model of Wilson Disease by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (2020)

Wilson disease is a rare inherited autosomal recessive disorder. As a consequence of genetic alterations in the <i>ATP7B</i> gene, copper begins to accumulate in the body, particularly in the liver and brain. Affected persons are prone to develop liver cancer and severe psychiatric and neurological symptoms. Clinically, the development of corneal Kayser-Fleischer rings and low ceruloplasmin concentrations (<20 mg/dL) are indicative of Wilson disease. However, the detection of elevated hepatic copper content (>250 µg/g dry weight) alone is still considered as the best but not exclusive diagnostic test for Wilson disease. Presently, specific copper stains (e.g., rhodanine) or indirect staining for copper-associated proteins (e.g., orcein) are widely used to histochemically visualize hepatic copper deposits. However, these procedures only detect lysosomal copper, while cytosolic copper is not detectable. Similarly, elemental analysis in scanning electron microscope with energy dispersive X-ray analysis (EDX) often leads to false negative results and inconsistencies. Here, we tested the diagnostic potential of laser ablation inductively-coupled mass spectrometry (LA-ICP-MS) that allows quantitative analysis of multiple elements. Comparative studies were performed in wild type and the <i>Atp7b</i> null mouse model. We propose LA-ICP-MS as a versatile and powerful method for the accurate determination of hepatic copper in people with Wilson disease with high spatial resolution.
Heat-removal performance scaling of interlayer cooled chip stacks (2010)

Interlayer cooling is the only heat removal concept which scales with the number of active tiers in a vertically integrated chip stack. In this work, we numerically and experimentally characterize the performance of a three tier chip stack with a footprint of 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The implementation of 100 μm pitch area array interconnect compatible heat transfer structures results in a maximal junction temperature increase of 54.7 K at 1bar pressure drop with water as coolant for 250 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> hot-spot and 50 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> background heat flux. The total power removed was 390 W which corresponds to a 3.9 kW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> volumetric heat flow. An efficient multi-scale modeling approach is proposed to predict the temperature response in the complete chip stack. The experimental validation confirmed an accuracy of +/- 10%. Detailed sub-domain modeling with parameter extraction is the base for the system level porous-media calculations with thermal field-coupling between solid fluid and solid solid interfaces. Furthermore, the strength and weakness of microchannel and pin fin heat transfer geometries in 2-port and 4-port fluid architectures is identified. Microchannels efficiently mitigate hot spots by distributing the dissipated heat to multiple cavities due to their low porosity. Pin fins with improved permeability and convective heat dissipation are advantageous at small power map contrast and aligned hot spots on the different tiers. Large stacks of 4 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> can be cooled sufficiently by the 4-port fluid delivery architecture. The flow rate is improved four times compared to the 2-port fluid manifold. The nonuniformity of the flow in case of the 4-port demands a more careful floor-planning. Furthermore optimization schemes such as hot-spot distribution, individual hot-spot heat flux adjustment, as well as hot-spot sub-millimeter dimensioning to minimize pumping power and maximize chip stack performance are proposed.
A multiresolution control method using view directional feature (1998)

Article A multiresolution control method using view directional feature Share on Authors: HyungSeok Kim Department of Computer Science, KAIST YooSungGoo, Taejon, Korea Department of Computer Science, KAIST YooSungGoo, Taejon, KoreaView Profile , Soon Ki Jung Department of Computer Engineering, Kyungpook National University PookGoo, Taegu, Korea Department of Computer Engineering, Kyungpook National University PookGoo, Taegu, KoreaView Profile , KwangYun Wohn Department of Computer Science, KAIST, YooSungGoo, Taejon Department of Computer Science, KAIST, YooSungGoo, TaejonView Profile Authors Info & Claims VRST '98: Proceedings of the ACM symposium on Virtual reality software and technologyNovember 1998 Pages 163–169https://doi.org/10.1145/293701.293723Online:02 November 1998Publication History 3citation863DownloadsMetricsTotal Citations3Total Downloads863Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
The feasibility and acceptability of a brief psychological intervention for adults with long-term health conditions and subthreshold depression delivered via community pharmacies: a mixed methods evaluation—the Community Pharmacies Mood Intervention Study (CHEMIST) (2022)

ISRCTN11290592.
The molecular structure of allenes and ketenes. 17. Excited states of the allene chromophore: photoelectron, circular dichroism and absorption spectroscopy of alkyl- and halogenoallenes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe molecular structure of allenes and ketenes. 17. Excited states of the allene chromophore: photoelectron, circular dichroism and absorption spectroscopy of alkyl- and halogenoallenesCornelis J. Elsevier, Peter Vermeer, Aharon Gedanken, and Wolfgang RungeCite this: J. Am. Chem. Soc. 1985, 107, 8, 2537–2547Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/ja00294a055https://doi.org/10.1021/ja00294a055research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts