gebhart/patrepeval huggingface dataset:
Response and resistance to cladribine in patients with advanced systemic mastocytosis: a registry-based analysis (2023)

We sought to evaluate the efficacy of the purine analogue cladribine in 79 patients with advanced systemic mastocytosis (AdvSM) using data from the 'German Registry on Disorders of Eosinophils and Mast Cells (GREM)'. The overall response rate according to modified Valent criteria (46 evaluable patients) for first- (1L) and second-line (2L) cladribine treatment was 41% (12/29) and 35% (6/17, P = 0.690), respectively, and the median overall survival (OS, all patients evaluable) was 1.9 years (n = 48) and 1.2 years (n = 31; P = 0.311). Univariate and multivariable analyses of baseline and on-treatment parameters identified diagnosis of mast cell leukemia (hazard ratio [HR] 3.5, 95% confidence interval [CI, 1.3-9.1], P = 0.012), eosinophilia ≥ 1.5 × 10<sup>9</sup>/L (HR 2.9 [CI 1.4-6.2], P = 0.006) and < 3 cycles of cladribine (HR 0.4 [CI 0.2-0.8], P = 0.008) as independent adverse prognostic parameters for OS. There was no impact of other laboratory (anemia, thrombocytopenia, serum tryptase) or genetic markers (mutations in SRSF2, ASXL1 or RUNX1) on OS. In consequence, none of the recently established prognostic scoring systems (MARS, IPSM, MAPS or GPSM) was predictive for OS. Modified Valent criteria were superior to a single factor-based response assessment (HR 2.9 [CI 1.3-6.6], P = 0.026). In conclusion, cladribine is effective in 1L and 2L treatment of AdvSM. Mast cell leukemia, eosinophilia, application of < 3 cycles and a lack of response are adverse prognostic markers.
Avian Paramyxovirus 4 Antitumor Activity Leads to Complete Remissions and Long-term Protective Memory in Preclinical Melanoma and Colon Carcinoma Models (2022)

Avulaviruses represent a diverse subfamily of non-segmented negative strand RNA viruses infecting avian species worldwide. To date, 22 different serotypes have been identified in a variety of avian hosts, including wild and domestic birds. APMV-1, also known as Newcastle disease virus (NDV), is the only avulavirus that has been extensively characterized due to its relevance for the poultry industry and, more recently, its inherent oncolytic activity and potential as a cancer therapeutic. An array of both naturally-occurring and recombinant APMV-1 strains has been tested in different preclinical models and clinical trials, highlighting NDV as a promising viral agent for human cancer therapy. To date, the oncolytic potential of other closely related avulaviruses remains unknown. Here, we have examined the <i>in vivo</i> anti-tumor capability of prototype strains of APMV serotypes -2, -3, -4, -6, -7, -8 and -9 in syngeneic murine colon carcinoma and melanoma tumor models. Our studies have identified APMV-4 Duck/Hong Kong/D3/1975 virus as a novel oncolytic agent with greater therapeutic potential than one of the NDV clinical candidate strains, La Sota. Intratumoral administration of the naturally-occurring APMV-4 virus significantly extends survival, promotes complete remission, and confers protection against re-challenge in both murine colon carcinoma and melanoma tumor models. Furthermore, we have designed a plasmid rescue strategy that allows us to develop recombinant APMV-4-based viruses. The infectious clone rAPMV-4 preserves the extraordinary antitumor capacity of its natural counterpart, paving the way to a promising next generation of viral therapeutics.
Comparison of Somatostatin Receptor Agonist and Antagonist for Peptide Receptor Radionuclide Therapy: A Pilot Study (2014)

Treatment of neuroendocrine tumors with radiolabeled sst antagonists is clinically feasible and may have a significant impact on peptide receptor radionuclide therapy.
Electrocorticographic high gamma activity versus electrical cortical stimulation mapping of naming (2005)

Subdural electrocorticographic (ECoG) recordings in patients undergoing epilepsy surgery have shown that functional activation is associated with event-related broadband gamma activity in a higher frequency range (>70 Hz) than previously studied in human scalp EEG. To investigate the utility of this high gamma activity (HGA) for mapping language cortex, we compared its neuroanatomical distribution with functional maps derived from electrical cortical stimulation (ECS), which remains the gold standard for predicting functional impairment after surgery for epilepsy, tumours or vascular malformations. Thirteen patients had undergone subdural electrode implantation for the surgical management of intractable epilepsy. Subdural ECoG signals were recorded while each patient verbally named sequentially presented line drawings of objects, and estimates of event-related HGA (80-100 Hz) were made at each recording site. Routine clinical ECS mapping used a subset of the same naming stimuli at each cortical site. If ECS disrupted mouth-related motor function, i.e. if it affected the mouth, lips or tongue, naming could not be tested with ECS at the same cortical site. Because naming during ECoG involved these muscles of articulation, the sensitivity and specificity of ECoG HGA were estimated relative to both ECS-induced impairments of naming and ECS disruption of mouth-related motor function. When these estimates were made separately for 12 electrode sites per patient (the average number with significant HGA), the specificity of ECoG HGA with respect to ECS was 78% for naming and 81% for mouth-related motor function, and equivalent sensitivities were 38% and 46%, respectively. When ECS maps of naming and mouth-related motor function were combined, the specificity and sensitivity of ECoG HGA with respect to ECS were 84% and 43%, respectively. This study indicates that event-related ECoG HGA during confrontation naming predicts ECS interference with naming and mouth-related motor function with good specificity but relatively low sensitivity. Its favourable specificity suggests that ECoG HGA can be used to construct a preliminary functional map that may help identify cortical sites of lower priority for ECS mapping. Passive recordings of ECoG gamma activity may be done simultaneously at all electrode sites without the risk of after-discharges associated with ECS mapping, which must be done sequentially at pairs of electrodes. We discuss the relative merits of these two functional mapping techniques.
Photonic Floquet media with a complex time-periodic permittivity (2018)

We study the formation of exceptional points (EPs) in a photonic medium with a complex time-periodic permittivity, i.e., $\ensuremath{\varepsilon}(t)={\ensuremath{\varepsilon}}_{o}+{\ensuremath{\varepsilon}}_{r}sin(\mathrm{\ensuremath{\Omega}}t)$. We formulate Maxwell's equations in the form of a first-order non-Hermitian Floquet Hamiltonian matrix and solve it analytically for the Floquet band structures. In the case when ${\ensuremath{\varepsilon}}_{r}$ is real, to the first order in ${\ensuremath{\varepsilon}}_{r}$, the band structures show a phase transition from an exact phase with real quasienergies to a broken phase with complex quasienergies inside a region of wave-vector space, the so-called $k$ gap. We show that the two EPs at the upper and lower edges of the $k$ gap have opposite chiralities in the stroboscopic sense. By picking up the mode with a positive imaginary quasienergy, the wave propagation inside the $k$ gap can grow exponentially. In three dimensions, such pairs of EPs span two concentric spherical surfaces in the $\stackrel{P\vec}{k}$ space and repeat themselves periodically in the quasienergy space with $\mathrm{\ensuremath{\Omega}}$ as the period. However, in the case when ${\ensuremath{\varepsilon}}_{r}$ is purely imaginary, the $k$ gap disappears and gaps in the quasienergy space are opened. Our analytical results agree well with finite-difference time domain simulations. To second order in ${\ensuremath{\varepsilon}}_{r}$, additional EP pairs are found for both the cases of real and imaginary ${\ensuremath{\varepsilon}}_{r}$. We also extend our theory to the case where the permittivity is simultaneously modulated in both space and time, i.e., $\ensuremath{\varepsilon}(x,t)={\ensuremath{\varepsilon}}_{o}+{\ensuremath{\varepsilon}}_{r}sin(\mathrm{\ensuremath{\Omega}}t\ensuremath{-}\ensuremath{\beta}x+\ensuremath{\phi})$. For a real ${\ensuremath{\varepsilon}}_{r}$, we find that EPs also exist when the modulation speed ${c}_{m}=\mathrm{\ensuremath{\Omega}}/\ensuremath{\beta}$ is faster than the speed of the wave travelling inside the medium.
Multiplier Theory and Operator Square Roots: Application to Robust and Time-Varying Stability (1996)

This paper considers the extension of a number of passive multiplier theory based results, previously known only for linear time invariant scalar systems, to time varying and multivariable settings. The extensions obtained here have important applications to the stability of both adaptive systems and linear systems in general. We demonstrate in this paper that at the heart of the extensions carried out here lies the result that if a stable multivariable and/or linear time varying system is stable under all scalar constant, positive feedback gains, then it has a well defined square root. The existence of this square root is demonstrated through a constructive Newton-Raphson based algorithm. The extensions provided here (dealing with robust stability and introduction of time-varying gains) though different in form from their linear time invariant scalar counterparts, do recover these as a special case.
Evaluation of the A/Seal/Mass/1/80 virus in squirrel monkeys (1983)

An influenza A virus isolated from seals [A/Seal/Mass/1/80 (H7N7)] and an isolate of this virus obtained from a human conjunctiva were evaluated for replication and virulence in squirrel monkeys. When the seal virus was administered intratracheally, it replicated in lungs and nasopharynges and induced illness almost to the same extent that a human influenza A virus [A/Udorn/72 (H3N2)] did. In one monkey that died of pneumonia, the seal virus was recovered from spleen, liver, and muscle as well as lung. After conjunctival administration in monkeys, the seal virus replicated to a peak titer in the conjunctivae 30-fold greater than that attained by the human virus, but this difference was not statistically significant. In contrast, the seal virus replicated less well than the human virus in the tracheae and nasopharynges when administered by the conjunctival route. These results indicate that the seal virus can replicate efficiently in primates, that it can spread systemically, and that it might differ from human virus in being able to replicate slightly better in primate conjunctival tissue.
Wearable computing for older adults (2014)

With recent interest in industry, wearable computers with head-mounted displays are about to become mainstream. As it is typical for novel technologies, development is directed towards early adopters. This typically excludes special target groups such as older adults with age related special needs. However, it is necessary to consider their requirements when the technology matures, as they can benefit from wearable computing. In this paper we present an explorative, qualitative study with three older adults that used a wearable computer with a head mounted display during everyday activities. We derive requirements from the usage of existing applications, describe emerging usage patterns, highlight promising applications, and the reaction of the public.
Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification (2019)

Abstract Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h −1 .
P‐198: Optically Clear Adhesives Enabling Foldable and Flexible OLED Displays (2017)

Flexible, foldable organic light emitting diode (OLED) displays have been conceptually demonstrated but not yet commercialized in a consumer electronics device. We will share progress and understanding of how 3M TM Optically Clear Adhesives (OCAs) can be used to laminate cover windows and touch sensors to enable active, dynamic folding of flexible OLED displays.
A Gibbs sampler for the identification of gene expression and network connectivity consistency (2006)

Our algorithm is available on request from the authors and soon to be posted on the web. See author's homepage for details, http://www.seas.ucla.edu/~liaoj/
Single dopant impact on electrical characteristics of SOI NMOSFETs with effective length down to 10nm (2010)

Although single dopant signatures have been observed at low temperature [1-2], the impact on transistor performance of a single dopant atom at room temperature is not yet well understood. Here, for the first time, we provide an in-depth understanding of single dopant influence on NMOSFETs characteristics by linking low and room temperature transport. We demonstrate that, for gate length of 30 nm and below (channel length down to 10 nm), the presence of a single dopant dramatically alters the subthreshold behaviour when the dopant is located in the middle of the channel. Moving the dopants away from the channel leads to enhanced variability above the threshold voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> .
Linear Superposition Electrical Impedance Tomography Imaging With Multiple Electrical/Biopsy Probes (2009)

In medical diagnostics, tissue is often examined with multiple discrete biopsies taken under ultrasound placement. In a previous theoretical study, we have suggested that the linear nature of the equations used in electrical impedance tomography (EIT) can be employed with the conventional practice of biopsy sampling to produce an image of the tissue between the biopsy samplings. Specifically, the biopsy probes can be used to record EIT-type electrical data during the discrete tissue sampling. The location of the discrete biopsy needle insertions available from the ultrasound placement of the probes can be combined with the electrical measurement data and used with linear superposition to produce a complete EIT image of the tissue between the sampled sites. In this study, we explore the concept experimentally using gel phantoms to simulate tissue and heterogeneities in the tissue. The experiments are performed in 2-D and 3-D configurations, and data are taken discretely, one at a time, through single electrical probe insertions. In the 2-D configuration, we were able to produce images of reasonable quality for heterogeneities with a diameter larger than 3 mm (conductivity ratio 1:5) and with relative conductivity differences above 50% (diameter 5 mm).
Enhanced Gene Transfer Efficiency in the Murine Striatum and an Orthotopic Glioblastoma Tumor Model, Using AAV-7- and AAV-8-Pseudotyped Vectors (2006)

In this study, recombinant AAV vectors pseudotyped with viral capsids derived from AAV serotypes 7 and 8 were evaluated for gene transfer in the murine striatum relative to vectors pseudotyped with AAV serotypes 2, 5, and 6. In comparison with rAAV serotype 2, pseudotyped vectors derived from AAV-7 and AAV-8 have increased transduction efficiency in the murine CNS, with the rank order rAAV-7 > rAAV-8 > rAAV-5 > rAAV-2 = rAAV-6, with all vectors demonstrating a marked tropism for neuronal transduction. Pseudotyped rAAV vector gene transfer in the brain after preimplantation of a murine 4C8 glioblastoma tumor was also evaluated. Efficiency of gene transfer to the orthotopic tumor was increased when using AAV-6, -7, and -8 capsid proteins in comparison with serotype 2, with the order rAAV-8 = rAAV-7 > rAAV-6 > rAAV-2 > rAAV-5. The increased gene transfer efficiency of rAAV vectors pseudotyped with the rAAV-8 capsid also provided enhanced therapeutic efficacy in a mouse model of glioblastoma multiforme, using vectors encoding an inhibitor of the vascular endothelial growth factor pathway. These studies demonstrate that rAAV vectors pseudotyped with capsids derived from AAV serotypes 7 and 8 provide enhanced gene transfer in the murine CNS and may offer increased therapeutic efficacy in the treatment of neurological disease.
New Helical Complexes with a Bis(bidentate) Schiff Base Ligand Containing a Flexible Spacer (2002)

Neutral complexes with the general empirical formula M(PTs) [M: Mn, Fe, Co, Cu, Zn, and Cd; H2PTs: N,N′-bis(2-tosylaminobenzylidene)-1,3-diaminopropane] were obtained by means of an electrochemical procedure. All complexes were characterised by elemental analyses, mass spectrometry, IR and 1H NMR spectroscopy, and magnetic measurements, where appropriate. Recrystallisation of the cobalt, copper, and zinc complexes yielded single crystals of [Co(PTs)] (1), [Cu(PTs)]·1.5CH3CN (2) and [Zn(PTs)]2·1.5H2O·CH3CN (3). Their X-ray characterisation shows that 1 and 2 are mononuclear tetrahedral single-stranded helical complexes in the solid state, while 3 is a double-helical compound containing a major and a minor groove, with the Schiff base acting as a bis(bidentate) N4 donor.
Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor (2013)

Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chemistry optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor. These dihydrothiazolopyridones potentiate receptor responses in recombinant systems. In vitro and in vivo drug metabolism and pharmacokinetic (DMPK) evaluation allowed us to select compound 16a for its assessment in a preclinical animal screen of possible antipsychotic activity. 16a was able to reverse amphetamine-induced hyperlocomotion in rats in a dose-dependent manner without showing any significant motor impairment or overt neurological side effects at comparable doses. Evolution of our medicinal chemistry program, structure activity, and properties relationships (SAR and SPR) analysis as well as a detailed profile for optimized mGlu5 receptor PAM 16a are described.
PERFORMANCE-BASED SEISMIC DESIGN PROVISIONS NEWLY INTRODUCED TO THE BUILDING STANDARD LAW OF JAPAN (2004)

The seismic design provisions of buildings in Japan was revised toward a performance-based structural engineering framework in 2000. The provisions provide two performance objectives: life safety and damage limitation of a building at two corresponding levels of earthquake motions. The design earthquake motions are defined in terms of the acceleration response spectra specified at the engineering bedrock to take account of the soil conditions and soil-structure interaction effects as properly as possible. The seismic performance shall be verified by comparing the predicted response values with the estimated limit values of a building.
Vertical Cavity Surface Emitting Lasers for Optical Signal Processing and Optical Computing Applications. (1994)

Abstract : This final technical report outlines the development of Vertical-Cavity Surface-Emitting Lasers (VCSELs) for use in high-speed parallel data links. During this contract, Optical Concepts has produced VCSELs with greatly improved performance, and has developed packaging technologies for VCSELs. VCSELs have been developed that operate at greater than 5 GHz with sub-milliamp threshold currents. With low turn on delays, these devices have demonstrated GHz data rates with no pre-bias. VCSEL arrays have been incorporated into high-speed, parallel1 fiber coupled packages. Optical Concepts has demonstrated packages using both top and bottom emitting VCSELs, and has developed an integrated microlens technology to ease packaging tolerances.
Evaluation of experimental epoxy monomers (1985)

Future generation aircraft need higher performance polymer matrices to fully achieve the weight savings possible with composite materials. New resins are being formulated in an effort to understand basic polymer behavior and to develop improved resins. Some polymer/curing agent combinations that could be useful are difficult to process. In the area of epoxies, a major problem is that some components have physical properties which make them difficult to utilize as matrix resins. A previous study showed that the use of ultrasonic energy can be advantageous in the mixing of curing agents into a standard epoxy resin, such as MY 720 (Ciba-Geigy designation). This work is expanded to include three novel epoxides.
Impact of through silicon via induced mechanical stress on fully depleted Bulk FinFET technology (2012)

This work provides for the first time an experimental assessment of the impact of thermo-mechanically induced stresses by copper through-silicon vias, TSVs, on fully depleted Bulk FinFET devices. Both n and p type FinFETs are significantly affected by TSV proximity, exhibiting lower impact on drive current with respect to the planar devices. The obtained results are in agreement with the thermo-mechanical models for Cu-TSV and are supported by the 4 point bending stress calibration.
Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis (2022)

Overall, the fucose residue in GHCer dictated the glycan conformation for its complexing with TRAX to release TRAX-sequestered PLCβ1, leading to Ca<sup>2+</sup> mobilization in endothelial cells and enhancing angiogenesis in tumor microenvironments.
ChemInform Abstract: Fluorine‐Enabled Cationic Gold Catalysis: Functionalized Hydration of Alkynes. (2011)

Abstract A one‐pot tandem addition/oxidative coupling/fluorination sequence performed with the alkyne, an arylboronic acid, water, and Selectfluor in the presence of a gold(I) catalyst affords α‐aryl‐α‐fluoroketones.
Synthesis and Properties of a Novel Polythiophene Derivative with a Side-Chain NLO Chromophore (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Properties of a Novel Polythiophene Derivative with a Side-Chain NLO ChromophoreK. G. Chittibabu, L. Li, M. Kamath, J. Kumar, and S. K. TripathyCite this: Chem. Mater. 1994, 6, 4, 475–480Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/cm00040a023https://doi.org/10.1021/cm00040a023research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts