gebhart/patrepeval huggingface dataset:
Revascularization in stable coronary artery disease: a combined perspective from an interventional cardiologist and a cardiac surgeon (2016)

It is now half a century since the start of coronary bypass graft surgery (CABG) with the first percutaneous coronary intervention (PCI) following just over a decade later. The relative merits of PCI vs. CABG for stable coronary artery disease (stable-CAD) have continued to be debated ever since and have been the focus of around 20 randomized trials and numerous registry studies, systematic reviews, and meta-analyses. The aim of this review is to identify areas of agreement, disagreement, and uncertainties in the role of PCI and CABG in patients with stable-CAD.
New scaled DCT algorithms for fused multiply/add architectures (1991)

The authors present novel scaled discrete cosine transform (DCT) and inverse scaled DCT algorithms designed for fused multiply/add architecture. Since the most popular case used in image processing involves 8*8 blocks (both emerging JPEG and MPEG standards call for DCT coding on blocks of this size), the authors discuss this case in detail. The scaled DCT and inverse scaled DCT each use 416 operations, so that, combined with scaling or descaling, each uses 480 operations. For the inverse, the descaling can be combined with computation of the IDCT (inverse DCT). If multiplicative constants, which depend on the quantization matrix, can be computed offline, then the descaling and IDCT can be computed simultaneously with 417 operations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Localization of the Dopamine D1Receptor Protein in the Human Heart and Kidney (1997)

The dopamine D1 receptor has recently been identified in the rat heart and kidney. In the present study, using Western blot analysis and light microscopic immunohistochemistry, we examined D1 receptor protein expression in the human kidney and heart. Antipeptide polyclonal rabbit antiserum was raised against the third extracellular domain of the native receptor and affinity-purified using a protein-A column. Selectivity of the antiserum was validated by recognition of the D1 receptor expressed in stably transfected LTK- cells and Sf-9 cells. The immunohistochemical staining for D1 receptor protein was distributed throughout the atrium and ventricular myocardium and in the coronary vessels. In the kidney, positive immunoreactive signal was detected in the proximal and distal tubules, the collecting ducts, and the large intrarenal vasculature, whereas staining was absent in the juxtaglomerular (JG) cells and the glomeruli. D1 receptor antiserum preadsorbed against the immunizing peptide did not produce significant staining. In Western blot analysis, a single 55-kD band was detected for the D1 receptor in membranes from the D1 receptor transfected Sf-9 cells but not in nontransfected cells. In the heart and kidney, we detected a 55-kD band as well as an additional 40-kD band, which may reflect partial degradation of the receptor protein. These results provide the first evidence for the localization of the dopamine D1 receptor protein in the human heart and kidney. The similar distribution of this subtype receptor in the human heart and kidney to that in the rat supports the possible (patho)physiological significance of the peripheral dopamine system in humans.
PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction (2013)

Collectively, our data suggest that TWEAK induces cardiac dysfunction via downregulation of PGC1α, through FN14-TRAF2-NFκB-dependent signaling. Selective targeting of the FN14-TRAF2-NFκB-dependent signaling pathway or augmenting PGC1α levels may serve as novel therapeutic strategies for cardiomyopathy and heart failure.
Delay asymptotics for a priority queueing system (2000)

In this paper, we study discrete-time priority queueing systems fed by a large number of arrival streams. We first provide bounds on the actual delay asymptote in terms of the virtual delay asymptote. Then, under suitable assumptions on the arrival process to the queue, we show that these asymptotes are the same. We then consider a priority queueing system with two queues. Using the earlier result, we derive an upper bound on the tail probability of the delay. Under certain assumptions on the rate function of the arrival process, we show that the upper bound is tight. We then consider a system with Markovian arrivals and numerically evaluate the delay tail probability and validate these results with simulations.
Flowspec Indirection-id Redirect for SRv6 (2000)

This document defines extensions to FlowSpec Redirect to indirection-
id Extended Community for SRv6. This extended community can trigger
advanced redirection capabilities to flowspec clients for SRv6. When
activated, this flowspec extended community is used by a flowspec
client to retrieve the corresponding next-hop and encoding information
within a localised indirection-id mapping table. The functionality
detailed in this document allows a network controller to decouple the
BGP flowspec redirection instruction from the operation of the
available paths.
Hydrocyclone/Filter for Concentrating Biomarkers from Soil (2008)

The hydrocyclone-filtration extractor (HFE), now undergoing development, is a simple, robust apparatus for processing large amounts of soil to extract trace amounts of microorganisms, soluble organic compounds, and other biomarkers from soil and to concentrate the extracts in amounts sufficient to enable such traditional assays as cell culturing, deoxyribonucleic acid (DNA) analysis, and isotope analysis. Originally intended for incorporation into a suite of instruments for detecting signs of life on Mars, the HFE could also be used on Earth for similar purposes, including detecting trace amounts of biomarkers or chemical wastes in soils.
A Security Methodology for Computer Networks (1988)

The world's businesses, industries, and governments are beginning to rely on computer networks for timely transmission of sensitive data between geographically distributed sites. To ensure the security integrity of the entire complex, the networks that bind these distributed facilities must be integral to all security considerations. The methodology described here provides a framework for developing the planning documentation and procedures for network security. It also bounds five security documentation and analysis problems that were previously unbounded. This methodology separates a computer network's “security life” into two phases. The first phase — design, review, and accreditation — deals with system-security planning, implementation, certification, and accreditation for operation. The second — or operational — phase involves processing unusual events that may be of security interest during the operation of a computer network. The various elements, relationships, and decisions for each phase are examined.
Novel High Efficiency Power Amplifier Mode Using Open Circuit Harmonic Loading (2019)

This paper introduces the Class O <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> power amplifier (PA) with high power-density and drain efficiency. A new waveform engineering-based design approach is proposed to realize a reliable high-efficiency PA operation while tuning both second and third harmonic impedances to open-circuit termination. The proposed theory derives the intrinsic current and voltage waveforms as a function of input second-harmonic tuning which is adopted to enable the realization of reliable Class O <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> PA operation. A multi-harmonic vector load-pull system is used for the practical validation that is carried out using a 10-W gallium nitride (GaN) transistor. On load-pull, the Class O <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> mode demonstrates a drain efficiency of 87% at an output power of 39.8 dBm with a gain of 10 dB at a frequency of 1.0 GHz.
Localization of Fe d-states in Ni-Fe-Cu alloys and implications for ultrafast demagnetization (2015)

Ni$_{80}$Fe$_{20}$ (Py) and Py-Cu exhibit intriguing ultrafast demagnetization behavior, where the Ni magnetic moment shows a delayed response relative to the Fe [S. Mathias et al., PNAS {\bf 109}, 4792 (2012)]. To unravel the mechanism responsible for this behavior, we have studied Py-Cu alloys for a wide range of Cu concentrations using X-ray magnetic circular dichroism (XMCD). The magnetic moments of Fe and Ni are found to respond very differently to Cu alloying: Fe becomes a strong ferromagnet in Py, with the magnetic moment largely unaffected by Cu alloying. In contrast, the Ni magnetic moment decreases continuously with increasing Cu concentration. Our results are corroborated by ab-initio calculations of the electronic structure, which we discuss in the framework of virtual bound states (VBSs). For high Cu concentrations, Ni exhibits VBSs below the Fermi level, which are likely responsible for an increased orbital/spin magnetic ratio at high Cu concentrations. Fe exhibits VBSs in the minority band, approximately 1 eV above the Fermi level in pure Py, that move closer to the Fermi level upon Cu alloying. A strong interaction between the VBSs and excited electrons above the Fermi level enhances the formation of localized magnons at Fe sites, which explains the different behavior between Fe and Ni during ultrafast demagnetization.
Doping Mechanism in Transparent Conductive ZnO Films Grown by Atomic Layer Deposition (2014)

Transparent conducting oxides (TCOs) have been one of the essential elements of various optoelectronic devices, photovoltaics, and photoelectrochemical energy-harvesting cells which require an electrically conducting layer ( s ~10 3 -10 4 S/cm) with high optical transparency (&gt;80%). The TCOs are typically doped with foreign elements, as in the cases of Sn-doped In 2 O 3 (ITO) and Al-doped ZnO (AZO), and become degenerate semiconductors with an extremely high electron concentration of 10 20 -10 21 cm -3 . While TCOs have been deposited by various methods including sputtering, pulsed laser deposition, chemical vapor deposition, and spray pyrolysis, recent emergence of nanostructured solar cells and organic light emitting diodes has accelerated necessity of ultrathin TCO coating onto complex or large surface area substrates at a low deposition temperature which are quite challengeable for the conventional deposition methods. In order to meet those emerging requirements, atomic layer deposition (ALD) has gathered great interest. Since ALD uses an alternative supply of source gases, conformal coating of desired films can be readily elucidated onto high-aspect-ratio structures and film thickness can be exactly controlled by repeating discrete ALD cycles. Therefore, there have been increasing demands of integrating ALD-grown TCOs into the emerging applications addressed above. In this presentation, we report structural and electrical properties of ‘atomic-layer-doped’ ZnO films. [1,2] Firstly, Al-doped ZnO films were deposited by ALD via alternate stacking of a ZnO matrix and AlO x dopant layers. Scanning TEM-HAADF analysis revealed that the ALD-AZO films have a unique layer-by-layer structure as those were grown. Upon correlation of the structural and electrical properties, effects of the layer-by-layer doping manner were interpreted in order to investigate a carrier generation mechanism of the ALD-AZO films. In the latter part, efforts of optimizing electrical properties of ALD-ZnO films will be given by controlling surface coverage of dopant ions incorporated in each atomic-doping layer. These efforts include two approaches; i) control of the amount of Al ions deposited during 1 ALD cycle of AlO x via process-parameter adjustment, and ii) introduction of other dopant oxides (group III: In, B, transition metals: Hf, Zr, Ti) which have different surface coverage. Among the tested dopants, it is remarkable that Ti exhibited the highest electrical conductivity (950 S/cm) and doping efficiency (51%). This finding is extraordinary compared to the conventional homogeneous compounds where Al has long been considered as one of the best dopants for the ZnO. [1] D.-J. Lee, K.-B. Kim et al. , Adv. Funct. Mater. 21 , 448 (2011). [2] D.-J. Lee, K.-B. Kim et al. , J. Electrochem. Soc. 158 , D277 (2011).
671: Defining Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy: A Proposal for a Standardized Definition (2005)

You have accessJournal of UrologyDiscussed Poster, Monday, May 23, 2005, 8:00am - 12:00 pm1 Apr 2005671: Defining Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy: A Proposal for a Standardized Definition Andrew J. Stephenson, Peter T. Scardino, James A. Eastham, Hans Lilja, Fernando J. Bianco, Zohar A. Dotan, and Michael W. Kattan Andrew J. StephensonAndrew J. Stephenson More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Hans LiljaHans Lilja More articles by this author , Fernando J. BiancoFernando J. Bianco More articles by this author , Zohar A. DotanZohar A. Dotan More articles by this author , and Michael W. KattanMichael W. Kattan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34911-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "671: Defining Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy: A Proposal for a Standardized Definition." The Journal of Urology, 173(4S), p. 183 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 183 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Andrew J. Stephenson More articles by this author Peter T. Scardino More articles by this author James A. Eastham More articles by this author Hans Lilja More articles by this author Fernando J. Bianco More articles by this author Zohar A. Dotan More articles by this author Michael W. Kattan More articles by this author Expand All Advertisement PDF downloadLoading ...
New Fluorogenic Probes for Oxygen and Carbene Transfer:  A Sensitive Assay for Single Bead-Supported Catalysts (2001)

A high-throughput screening assay for atom transfer catalysis has been developed. This assay is based on two probes, developed herein, which generate highly fluorescent products upon carbene or oxygen atom transfer. The emission wavelength of probes 1 and 5 shift significantly (up to 90 nm) upon epoxidation, allowing detection of product at 3% conversion. Probe 7 is not fluorescent, while fluorescence emission by carbene insertion/rearrangement product 8 allows detection at less than 1% conversion. Such sensitivity allows for examination of single-bead reactions in a high throughput array format (1536 wells per plate), and provides a broad detection window ranging from single to high turnover numbers. Thousands of metal complexes are evaluated in a single screening experiment. Preliminary screening of a diverse ligand library with probe 7 in the presence of Rh(II) uncovered new catalysts capable of cyclopropanation and C-H insertion.
Development of Multiplex PCR Assays for the Identification of the 33 Serotypes of Streptococcus suis (2013)

Streptococcus suis is an important zoonotic agent causing severe diseases in pigs and humans. To date, 33 serotypes of S. suis have been identified based on antigenic differences in the capsular polysaccharide. The capsular polysaccharide synthesis (cps) locus encodes proteins/enzymes that are responsible for capsular production and variation in the capsule structures are the basis of S. suis serotyping. Multiplex and/or simplex PCR assays have been developed for 15 serotypes based on serotype-specific genes in the cps gene cluster. In this study, we developed a set of multiplex PCR (mPCR) assays to identify the 33 currently known S. suis serotypes. To identify serotype-specific genes for mPCR, the entire genomes of reference strains for the 33 serotypes were sequenced using whole genome high-throughput sequencing, and the cps gene clusters from these strains were identified and compared. We developed a set of 4 mPCR assays based on the polysaccharide polymerase gene wzy, one of the serotype-specific genes. The assays can identify all serotypes except for two pairs of serotypes: 1 and 14, and 2 and 1/2, which have no serotype-specific genes between them. The first assay identifies 12 serotypes (serotypes 1 to 10, 1/2, and 14) that are the most frequently isolated from diseased pigs and patients; the second identifies 10 serotypes (serotypes 11 to 21 except 14); the third identifies the remaining 11 serotypes (serotypes 22 to 31, and 33); and the fourth identifies a new cps cluster of S. suis discovered in this study in 16 isolates that agglutinated with antisera for serotypes 29 and 21. The multiplex PCR assays developed in this study provide a rapid and specific method for molecular serotyping of S. suis.
Paper 200: Osteoarthritis Incidence Ten Years After Arthroscopic ACL Reconstruction (2012)

During the past several decades, many changes in the management of an anterior cruciate ligament (ACL) tear have occurred, regarding the preservation of the meniscal tissue, arthroscopic techniques, and rehabilitation. Limitations of previous studies, in addition to ongoing modifications in ACL deficiency management, emphasize the need for studies with long-term follow-up to evaluate contemporary practices. The purpose of this study was to evaluate the long-term outcomes specifically regarding OA incidence following a modern management of ACL tear, including arthroscopic procedure using a bone-tendon patellar-bone auto-graft (BTPB) along with early rehabilitation.
THE EFFECTS OF PLASMA AND ALBUMIN INFUSION ON ORGAN FUNCTION AND SEPSIS MARKERS IN EXPERIMENTAL GRAM-NEGATIVE SEPSIS (1994)

To study the effects of early plasma versus albumin infusion on vital organ function and the appearance of central sepsis mediators in septic shock, three groups of anesthetized piglets (n = 28) were inoculated with live Eschericia coli. Group I received fresh frozen plasma, group II received albumin, whereas group III served as nontreated septic controls. Plasma-treated animals exhibited improved survival (p < .02) compared with controls, and improved organ function compared with both controls and albumin-treated animals. Plasma infusion was associated with increased levels of endotoxin (p < .02) and terminal complement complex (TCC) (p < .03), and persisting high levels of tumor necrosis factor (TNF). Following albumin infusion TNF levels decreased to baseline values (p < .01), whereas endotoxin and TCC levels did not change significantly. Our study shows a beneficial effect of early plasma infusion on survival and vital organ function in septic animals. The effect of plasma infusion on circulating levels of endotoxin, TNF, and TCC may be potentially deleterious in uncompensated stages of septic shock.
Correlative infrared nanospectroscopic and nanomechanical imaging of block copolymer microdomains (2016)

Intermolecular interactions and nanoscale phase separation govern the properties of many molecular soft-matter systems. Here, we combine infrared vibrational scattering scanning near-field optical microscopy (IR s-SNOM) with force-distance spectroscopy for simultaneous characterization of both nanoscale optical and nanomechanical molecular properties through hybrid imaging. The resulting multichannel images and correlative analysis of chemical composition, spectral IR line shape, modulus, adhesion, deformation, and dissipation acquired for a thin film of a nanophase separated block copolymer (PS-b-PMMA) reveal complex structural variations, in particular at domain interfaces, not resolved in any individual signal channel alone. These variations suggest that regions of multicomponent chemical composition, such as the interfacial mixing regions between microdomains, are correlated with high spatial heterogeneity in nanoscale material properties.
Clinical praxis and laboratory procedures in subrenal capsule assay (SRCA). (1985)

Subrenal capsule assay (SRCA) is a promising method in cancer research and in the selection of individual chemotherapy for cancer patients. The laboratory procedures of SRCA are as follows: on day zero 1 X 1 X 1 mm pieces of fresh human tumour are carefully prepared. The pieces are transferred by a trocar under the outer capsule of normal immunocompetent mice, one piece to each. The mice (about 30-40/test) are divided randomly into groups of at least five. The size of each piece (initial size) is measured in situ by a stereomicroscope fitted with an ocular micrometer. On days 1-5 cytostatics are administered to the animals. On day 6 the animals are killed and the final tumour size is measured. The difference between the final and initial tumour size describes the response of the tumour to the treatments. The critical point of the assay is the selection of the tumour fragment which has to be representative, as homogeneous as possible and contain living tumour cells. When the sample is in pieces of about 3 X 3 mm (4-5 tumour fragments are sufficient for the assay) in the culture medium, it may be stored in an ice bath or at room temperature for one day. During this time, though as rapidly as possible, the sample has to be delivered to a research laboratory where the SRCA is carried out.
Metal filled porous carbon (2023)

A porous carbon scaffold with a surface and pores, the porous carbon scaffold containing a primary metal and a secondary metal, where the primary metal is a metal that does not wet the surface of the pores of the carbon scaffold but wets the surface of the secondary metal, and the secondary metal is interspersed between the surface of the pores of the carbon scaffold and the primary metal.
Relationships between C-reactive protein concentration and genotype in healthy volunteers (2008)

Selected genetic polymorphisms of the CRP gene are independently associated with higher basal hs-CRP concentrations in healthy adults. Larger studies are needed to perform haplotype analyses and to adequately evaluate the relationship between hs-CRP and genetic polymorphisms with lower allelic frequencies.
Associative memory of weakly connected oscillators (2002)

It is a well-known fact that oscillatory networks can operate as Hopfield-like neural networks, the only difference being that their attractors are limit cycles: one for each memorized pattern. The neuron activities are synchronized on the limit cycles, and neurons oscillate with fixed phase differences (time delays). We prove that this property is a natural attribute of general weakly connected neural networks, and it is relatively independent of the equations that describe the network activity. In particular, we prove an analogue of the Cohen-Grossberg convergence theorem for oscillatory neural networks.
Rapid and Sustained Symptom Relief in Patients With Ulcerative Colitis Treated With Filgotinib: Data From the Phase 2b/3 SELECTION Trial (2022)

Filgotinib 200 mg daily resulted in rapid and sustained improvements in both UC symptoms and HRQoL.