gebhart/patrepeval huggingface dataset:
18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer (2011)

(18)FDG-PET seems to serve as a rapid, noninvasive PD marker of IGF-1R/IR inhibition following a single dose of OSI-906 and should be explored clinically as a predictive clinical biomarker in patients undergoing IGF-1R/IR-directed cancer therapy.
Endovascular Repair of Abdominal Aortic Aneurysm: Follow-up with Noninvasive Vascular Elastography in a Canine Model (2015)

NIVE may be able to help characterize endoleak and thrombus organization, regardless of the size, pressure, and type of endoleak.
Abstract #5487: XmAb®5592: Fc-engineered anti-HM1.24 monoclonal antibody with potent in vitro and in vivo efficacy against multiple myeloma (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

HM1.24 (also known as CD317 or BST2) is a type II glycoprotein that is preferentially and highly expressed on malignant plasma cells, representing an attractive immunotherapy target for multiple myeloma. Here we present the characterization of a novel Fc-engineered and humanized anti-HM1.24 antibody (XmAb5592) that was generated using our XmAb® antibody engineering technologies. The main features of this antibody are i) increased affinity for Fc gamma receptors (Fc\#947;R), ii) improved effector function, and iii) significantly increased antitumor potency. The Fv region was humanized and engineered to maintain high affinity and specificity, increase stability and expression, and decrease immunogenicity. The antibody-dependent cell-mediated cytotoxicity (ADCC) of XmAb5592 was substantially higher relative to a native/non Fc-engineered version (anti-HM1.24 IgG1) of the antibody when tested in vitro against a panel of multiple myeloma cell lines including RPMI 8226, OPM-2, U266, LP-1 and EJM. ADCC efficacy (% lysis) of Fc-engineered antibody ranged from 50-90%, whereas the IgG1 version mediated little ADCC (10-30% lysis) on different cell lines. HM1.24 antigen is expressed on the surface of these myeloma cell lines to a varying degree, with maximal expression seen on RPMI 8226. XmAb5592 also induced robust anti-proliferative activity against RPMI 8226. The in vivo efficacy of XmAb5592 was evaluated in murine subcutaneous (sc) xenograft models using the RPMI 8226 myeloma cell line. Administration of XmAb5592 (9mg/kg, ip, 2x/week for 4 weeks) led to a significant reduction in growth of established tumors compared to a non-engineered IgG1 anti-HM1.24 analog. At the end of the study 7/15 mice were tumor free in XmAb treatment group versus only 1/15 tumor free mice in the IgG1 group. An anti-HM1.24 antibody with Fc region engineered to completely ablate binding to Fc\#947;Rs (knock-out) behaved equivalent to the PBS vehicle control in these studies, again underlining the significance of interaction with Fc\#947;R for anti-tumor efficacy. These results suggest that XmAb5592, an anti-HM1.24 antibody engineered for increased effector function is a promising next-generation immunotherapeutic for the treatment of multiple myeloma.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5487.
SGN-30 (Seattle genetics). (2006)

Seattle Genetics is developing SGN-30, an intravenously administered recombinant anti-CD30 monoclonal antibody for the potential treatment of Hodgkin's disease, certain non-Hodgkin's lymphomas, specific leukemia, and immunological diseases such as multiple sclerosis and systemic lupus erythematosus. Phase II trials in patients with Hodgkin's disease, anaplastic large cell lymphoma, and cutaneous lymphoma have been conducted in the U.S. and Europe.
Beam-array combination with planar integrated optics for three-dimensional multistage interconnection networks (1997)

We propose a configuration of planar integrated optics for three-dimensional multistage interconnection networks. To show the feasibility of cascading operations in the planar integrated optics, we present experimental results on the beam combination of signal- and power-beam arrays at a node stage. The beam-combination efficiency measured in the experiment is ~42% of the theoretical limit.
Increased sympathetic nerve activity and reduced cardiac baroreflex sensitivity in rheumatoid arthritis (2016)

Rheumatoid arthritis (RA) is a chronic inflammatory condition associated with increased cardiovascular morbidity/mortality and an incompletely understood pathophysiology. In animal studies, central and blood borne inflammatory cytokines that can be elevated in RA evoke pathogenic increases in sympathetic activity and reductions in baroreflex sensitivity (BRS). We hypothesized that muscle sympathetic nerve activity (MSNA) was increased and BRS decreased in RA. MSNA, blood pressure and heart rate (HR) were recorded in age- and sex-matched RA-normotensive (n = 13), RA-hypertensive patients (RA-HTN; n = 17), normotensive (NC; n = 17) and hypertensive controls (HTN; n = 16). BRS was determined using the modified Oxford technique. Inflammation and pain were determined using serum high sensitivity C-reactive protein (hs-CRP) and a visual analogue scale (VAS), respectively. MSNA was elevated similarly in RA, RA-HTN and HTN patients (32 ± 9, 35 ± 14, 37 ± 8 bursts min<sup>-1</sup> ) compared to NC (22 ± 9 bursts min<sup>-1</sup> ; P = 0.004). Sympathetic BRS was similar between groups (P = 0.927), whereas cardiac BRS (cBRS) was reduced in RA, RA-HTN and HTN patients [5(3-8), 4 (2-7), 6 (4-9) ms mmHg<sup>-1</sup> ] compared to NC [11 (8-15) ms mmHg<sup>-1</sup> ; P = 0.002]. HR was independently associated with hs-CRP. Increased MSNA and reduced cBRS were associated with hs-CRP although confounded in multivariable analysis. VAS was independently associated with MSNA burst frequency, cBRS and HR. We provide the first evidence for heightened sympathetic outflow and reduced cBRS in RA that can be independent of hypertension. In RA patients, reported pain was positively correlated with MSNA and negatively correlated with cBRS. Future studies should assess whether therapies to ameliorate pain and inflammation in RA restores autonomic balance and reduces cardiovascular events.
A Review of Disparities in Oncology Care for Patients with Limited Access and Minorities, in an Oncology Setting, an Unmet Need for this Group of Patients to Experimental Therapies (2021)

It is expected that half of the population in the US by 2045 are expected to be non Hispanic white, per US census Bureau projections.
Einfluß der Chemolyse auf die physikalischen Eigenschaften und die Steindesintegration künstlicher Harnsteine (BON(N)-STONES) (1999)

Fragestellung: Die verschiedenen Steinarten weisen deutliche Unterschiede zwischen den akustischen und mechanischen Eigenschaften auf, welche wichtige Parameter für die Bestimmung der Desintegrationsfähigkeit unter Stoßwelleneinfluß sind. Es sollte überprüft werden, ob eine Beeinflussung der Desintegrationsfähigkeit und damit der Effektivität einer Stoßwellenlithotripsie (ESWL) durch Veränderung der physikalischen Eigenschaften der Harnsteine mittels Chemolyse (Kalziumoxalatsteine mit EDTA und Harnsäuresteine mit Tromethamin) möglich ist.
Improved high-temperature performance of 1.3-1.5-/spl mu/m InNAsP-InGaAsP quantum-well microdisk lasers (1997)

We report for the first time lasing action in the InNAsP-InGaAsP material system. Dramatic improvement in lasing action in a microdisk cavity was observed at elevated temperature up to 70/spl deg/C, which is about 120/spl deg/C higher than that of InGaAs-InGaAsP microdisk. This resulted in the first optically pumped InNAsP-InGaAsP microdisk lasers capable of above room-temperature lasing. The improvement of lasing temperature can be attributed to a large conduction band offset between the quantum well and barriers in the InNAsP-InGaAsP material system.
Five-Year Incidence of Amyotrophic Lateral Sclerosis in British Columbia (2010-2015) (2016)

The incidence of ALS in BC was found to be consistent with international findings though nominally higher than that in other Canadian provinces to date.
Microfibrous Entrapped ZnO-Support Sorbents for High Contacting Efficiency H2S Removal from Reformate Streams in PEMFC Applications (2005)

A sintered microfibrous carrier consisting of 2.0 - 3.0 vol% of 4 and 8 µm (dia.) Ni fibers is utilized to entrap from 20 to 30 vol% of 150-250 µm (dia.) carbon and SiO2 support particulates. Zinc oxide is then placed onto the supports by impregnation at loadings ranging from 15 to 20 wt%. Two different sorbent recipes have been developed. ZnO/Carbon entrapped material for low temperature use is envisioned to operate as a last line of defense at stack temperatures. ZnO/SiO2 entrapped material is employed for regenerable use in a continuous batch mode at ca. 400°C to scavenge bulk H2S. The nano-dispersed nature of ZnO combined with the use of small support particulates promotes high ZnO utilization, high contacting efficiency, and high accessibility of ZnO. At equivalent bed volumes, microfibrous entrapped sorbents provide 2- to 3-fold longer breakthrough time for H2S (with a 67% reduction in sorbent loading), compared to packed beds of commercial 1-2 mm extrudates. Five-log reductions in H2S concentration with up to 67% ZnO utilization at breakthrough are achieved. Hydrogen sulfide concentrations from 50 ppmv (up to 20,000 ppmv) can be reduced to as little as 0.1 ppmv (at R.T.) and 0.6 ppmv (at 400°C) in 30% H2O at face velocities of 1.2-1.7 cm/s for layers as thin as 1.0 mm. Regenerability in air at 500-600°C is also facilitated by the nano-dispersed nature of the ZnO and the use of small support particulates. The recovery percentage of ZnO utilization using microfibrous entrapped sorbents is up to 5-fold higher than that for packed beds of 1-2 mm commercial extradates. Furthermore, composite beds consisting of packed beds of large extradates (ca. 1-2 mm dia.) followed by the above noted microfibrous entrapped sorbents as polishing layers has been demonstrated with a great extension in gas life. This approach synergistically combines the high volume loading of packed beds and the overall contacting efficiency of small particulates.
Bioactivity of Small Intestinal Submucosa and Oxidized Regenerated Cellulose/Collagen (2008)

SISWM shows much greater bioactivity than ORC. This is likely related to its close structural and biochemical approximation to natural dermal extracellular matrix and may help explain the strong clinical successes of SISWM.
Weaving the model web: a multi-modeling approach to concepts and features in domain engineering (2002)

This paper describes an advance in understanding the semantics of concepts and features in domain modeling for software reuse, incorporated into Organization Domain Modeling (ODM) Version 2. Previous approaches to feature modeling, such as FODA, use a single model with a particular semantics (AND/OR linkages, constraints) and a specific feature typology. ODM V2 utilizes a multi-modeling approach based on Sigma, a mathematical formalism (developed at Synquiry) for reasoning about how multiple abstractions of sets of instances interrelate and combine to give a unified understanding of a subject. Sigma defines a number of semantic relationships that can hold between separate conceptual models linked into a larger model web. One of these inter-model relationships captures the needed semantics for a flexible and general notion of features within a domain modeling context. The paper describes previous approaches to feature modeling in domain engineering, ODM's goals of general applicability which created requirements for a different approach, and key elements of the Sigma approach and its application to domain concept and feature modeling.
High-quality Si_3N_4 circuits as a platform for graphene-based nanophotonic devices (2013)

Hybrid circuits combining traditional nanophotonic components with carbon-based materials are emerging as a promising platform for optoelectronic devices. We demonstrate such circuits by integrating single-layer graphene films with silicon nitride waveguides as a new architecture for broadband optical operation. Using high-quality microring resonators and Mach-Zehnder interferometers with extinction ratios beyond 40 dB we realize flexible circuits for phase-sensitive detection on chip. Hybrid graphene-photonic devices are fabricated via mechanical transfer and lithographic structuring, allowing for prolonged light-matter interactions. Our approach holds promise for studying optical processes in low-dimensional physical systems and for realizing electrically tunable photonic circuits.
Characteristics of plume plasma and its effects on ablation depth during ultrashort laser ablation of copper in air (2012)

Abstract The characteristics of plume plasma induced by ultrashort laser ablation of copper in air are studied experimentally and theoretically in this paper. The plasma front evolutions are captured using a high-speed intensified charge-coupled device camera, while the plasma temperature and electron number density evolutions are obtained from the plasma emission spectra measured by a high-precision spectrometer. For the theoretical study, a hybrid simulation model is proposed to combine an atomistic model for the early stage and a hydrodynamic model for the later stage. The simulation model is validated against the measurement results and shown to be capable of predicting plasma properties for a broader range of fluence, without being constrained by the signal strength as in the measurements. Both experimental and theoretical results show that the nonlinear relationship between plasma properties and laser fluence directly relates to the relationship between ablation depth and laser fluence. Therefore, the measurable and predictable plasma properties reveal the underlying ablation mechanism that has been studied primarily by theory.
Single-molecule measurements in microwells for clinical applications (2019)

The ability to detect and analyze proteins, nucleic acids, and other biomolecules is critical for clinical diagnostics and for understanding the underlying mechanisms of disease. Current detection methods in clinical and research laboratories rely upon bulk measurement techniques such as immunoassays, polymerase chain reaction, and mass spectrometry to detect these biomarkers. However, many potentially useful protein or nucleic acid biomarkers in blood, saliva, or other biofluids exist at concentrations well below the detection limits of current methods, necessitating the development of more sensitive technologies. Single-molecule measurements are poised to address this challenge, vastly improving sensitivity for detecting low abundance biomarkers and rare events within a population. Microwell arrays have emerged as a powerful tool for single-molecule measurements, enabling ultrasensitive detection of disease-relevant biomolecules in easily accessible biofluids. This review discusses the development, fundamentals, and clinical applications of microwell-based single-molecule methods, as well as challenges and future directions for translating these methods to the clinic.
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance (2011)

These data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions. The early-onset insulin resistance during HFD feeding is more likely related to acute tissue lipid overload.
An Analysis of Enrollment and Query Attacks on Hierarchical Bloom Filter-Based Biometric Systems (2021)

A Hierarchical Bloom Filter (HBF) -based biometric framework was recently proposed to provide compact storage, noise tolerance, and fast query processing for resource-constrained environments, e.g., Internet of things (IoT). While security and privacy were also touted as features of the HBF, it was not thoroughly evaluated. Compared to the classical BFs, the HBF uses a threshold parameter to make robust authentication decisions when the HBF encounters noise in the biometric input which one would think might lead to security issues. In this paper, the attack vectors that could compromise the HBF security by increasing the false positive authentication of non-members and by leaking soft information about enrolled members are explored. With quantitative analyses, HBF-based biometric system security under these well-defined attack vectors is evaluated and it is concluded that the framework is more difficult to attack than the classical Bloom Filter. Further, experimental results show that soft biometric information is also kept private.
Aerodynamic-Shape Optimization of Supersonic-Missiles Using Monte-Carlo (2016)

This paper presents a fast and reliable technique for aerodynamic shape optimization of supersonic missiles using Monte Carlo optimization method. The technique is based on two modules: Aerodynamics module and optimization module. The aerodynamic module is based on components build-up method where analytical, and semi-empirical of different missile components were added together, with some interference factors, to calculate the overall aerodynamics of the missile. The Aerodynamics module is validated against known wind tunnel data and showed good agreement. The optimization module is aimed at finding Missile geometry (such as length, fins dimensions and fins location, etc.) which maximize lift-over-drag using Monte Carlo technique. Monte Carlo simulation Technique has proved itself as a simple and easy to implement tool for aerospace vehicles shape optimization.
Anionic Ring-Opening Polymerization of Octamethylcyclotetrasiloxane in the Presence of 1,3-Bis(aminopropyl)-1,1,3,3-tetramethyldisiloxane (1985)

Polyorganosiloxanes are probably the most widely used and studied class of "semi-inorganic" polymers. There are a variety of interesting and useful properties exhibited by these materials that make them worthy of study. For example, they exhibit high lubricity, low glass transition temperatures, good thermal stability, high gas permeability, unique surface properties, and low toxicity (1). Cyclic organosiloxanes and silanol oligomers may be readily prepared by the hydrolysis of chlorosilanes, according to Scheme 1 (1). The predominant cyclics are those corresponding to x=4 or 5, while the strained cyclic trimer is present only in small quantities. Scheme 1. Preparation of cyclic organosiloxanes and chlorosilanes.(1) Polydimethylsiloxane oligomers may be easily prepared by the acid or base catalyzed ring opening polymerization of the cyclic tetramer, octamethylcyclotetrasiloxane. The molecular weight of the polymer prepared may be controlled by the addition of a linear disiloxane as an endblocker (2,3,4). When the disiloxane is hexamethyldisiloxane, this is the well-studied case of the preparation of
Bunching visibility of parametric emission in Semiconductor 1D Microcavities (2012)

Poster
Electron microscopy may reveal structure of docosahexaenoic acid‐rich oil within Schizochytrium sp (2000)

Schizochytrium sp. is an algae-like microorganism utilized for commercial production of docosahexaenoic acid (DHA)-rich oil and dried microalgae for use as a source of DHA in foods, feeds, and nutritional supplements. Electron microscopic analysis of whole cells of Schizochytrium sp. employing sample preparation by high-pressure freeze substitution suggests the presence of secondary and tertiary semicrystalline structures of triacylglycerols within the oil bodies in Schizochytrium sp. A fine secondary structure consisting of alternating light- and dark-staining bands was observed inside the oil bodies. Dark bands were 29 +/- 1 A in width, and light bands were 22 +/- 1 A in width. The tertiary (three-dimensional) structure may be a multilayered ribbon-like structure which appears coiled and interlaced within the oil body. In freeze-fracture photomicrographs, Schizochytrium oil bodies exhibited fracture planes with terraces averaging 52 +/- 7 A in height which could correspond to the combined width of two halves of two light bands and one dark band observed in the high-pressure freeze substitution photomicrographs. The results suggest that triacylglycerols within Schizochytrium sp. oil bodies may be organized in a triple chain-length structure. High-pressure freeze substitution electron micrographs of two other highly unsaturated oil-producing species of microalgae, Thraustochytrium sp. and Isochrysis galbana, also revealed this fine structure, whereas microalgae containing a higher proportion of saturated oil did not. The results suggest that the staining pattern is not an artifact of preparation and that the triple chain-length conformation of triacylglycerols in Schizochytrium sp. oil bodies may be caused by the unique fatty acid composition of the triacylglycerols.
Regional multilineage differentiation potential of meniscal fibrochondrocytes: Implications for meniscus repair (2007)

The knee menisci are wedge-shaped semilunar fibrocartilaginous structures that reside between the femur and tibia and function to transmit and distribute load. These structures have characteristics of both fibrous and cartilaginous tissues. The cartilage-like inner region and the fibrous vascularized outer region each has a distinct extracellular matrix, and resident meniscal fibrochondrocytes (MFCs) with distinct morphologies dependent on their location. Damage to the meniscus is common, and disruption of tissue structure and function result in erosion of the underlying articular cartilage. It has been observed that damage in the vascular periphery undergoes spontaneous repair, whereas damage of the inner region does not heal. While vascularity of the peripheral region plays a role in healing, recent findings have also suggested that local cellular composition influences local healing capacity. This study examined the variation in multipotential characteristics of cell populations isolated from different regions of the bovine meniscus. MFCs were isolated from the outer (vascular), inner (avascular), and horn (mixed) regions and induced toward chondrogenic, adipogenic, and osteogenic lineages. The results of this study suggest that MFCs from all regions of the meniscus possess a multilineage differentiation capability, particularly toward chondrogenesis and adipogenesis. MFCs from the outer region were most plastic, differentiating along all three mesenchymal lineages. These findings may underlie the experimental observation of improved integration of meniscus grafts from the outer zone and may have implications for developing strategies of cell-based meniscus repair.
Characterization of Markerless Tumor Tracking Using the On-Board Imager of a Commercial Linear Accelerator Equipped With Fast-kV Switching Dual-Energy Imaging (2020)

Fast-kV switching, DE imaging was implemented on the on-board imager of a commercial linear accelerator. DE imaging resulted in improved MTT accuracy over SE imaging. Such an approach may have application for MTT of patients with lung cancer receiving stereotactic body radiation therapy, particularly for small tumors where MTT with SE imaging may fail.