gebhart/patrepeval huggingface dataset:
A phase I trial of cyclosporine for hospitalized patients with COVID-19 (2022)

BACKGROUNDCOVID-19 remains a global health emergency with limited treatment options, lagging vaccine rates, and inadequate healthcare resources in the face of an ongoing calamity. The disease is characterized by immune dysregulation and cytokine storm. Cyclosporine A (CSA) is a calcineurin inhibitor that modulates cytokine production and may have direct antiviral properties against coronaviruses.METHODSTo test whether a short course of CSA was safe in patients with COVID-19, we treated 10 hospitalized, oxygen-requiring, noncritically ill patients with CSA (starting at a dose of 9 mg/kg/d). We evaluated patients for clinical response and adverse events, measured serum cytokines and chemokines associated with COVID-19 hyperinflammation, and conducted gene-expression analyses.RESULTSFive participants experienced adverse events, none of which were serious; transaminitis was most common. No participant required intensive care unit-level care, and all patients were discharged alive. CSA treatment was associated with significant reductions in serum cytokines and chemokines important in COVID-19 hyperinflammation, including CXCL10. Following CSA administration, we also observed a significant reduction in type I IFN gene expression signatures and other transcriptional profiles associated with exacerbated hyperinflammation in the peripheral blood cells of these patients.CONCLUSIONShort courses of CSA appear safe and feasible in patients with COVID-19 who require oxygen and may be a useful adjunct in resource-limited health care settings.TRIAL REGISTRATIONThis trial was registered on ClinicalTrials.gov (Investigational New Drug Application no. 149997; ClinicalTrials.gov NCT04412785).FUNDINGThis study was internally funded by the Center for Cellular Immunotherapies.
Abstract 5778: Fragment-based drug discovery of selective inhibitors of fibroblast growth factor receptor (FGFr) (2010)

Abstract Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFr) signalling as being key to the molecular pathology of cancer. This poster will describe fragment based drug discovery using biophysical screening to identify initial fragments. Subsequently, in the fragments-to-leads stage a detailed structural understanding of the binding interactions between the fragment and its target protein utilised X-ray crystallography and NMR. Starting with different fragments allows several lead series to be identified, often by synthesizing only small numbers of compounds. A fragment screening campaign was conducted against the FGFr-1 to detect very low molecular weight compounds that bound to the hinge region of the kinase. The screening produced several fragment molecules (Molecular Weight &amp;lt;250 Da) which were in the micromolar range and confirmed binding mode in X-ray crystallography. One X-ray hit series that was 120 uM verse FGFr-3 will be described. Several iterations of structure-guided medicinal chemistry led to the identification of a lead compound with 3 nM affinity for FGFr-3, good cell activity and 30-fold selectivity verse VEGFr-2 with good oral activity. The lead was optimised to afford a compound that showed good PK/PD and efficacy. This poster represents first disclosure of the structure of the lead series and illustrates how a fragment-based drug discovery approach can be efficiently used to discover compounds advanced nanomolar compounds with oral bioavailability. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5778.
A secure and scalable telemonitoring system using ultra-low-energy wireless sensor interface for long-term monitoring in life science applications (2013)

A scalable telemonitoring system for secure long-term monitoring of signals in life-science applications is presented that enables unobtrusive remote patient monitoring with small and lightweight general-purpose sensor nodes. Sensor data are sent to a retail smartphone via the ultra-low-energy wireless ANT protocol and forwarded over 2G, 3G or Wi-Fi to the cloud-based IPM-mHealth Portal that provides services for administration, communication, live visualization and data analysis. Additional protocols improve reliability and flexibility of the ANT interface and all wireless transmissions are encrypted by either SSL or the computationally lightweight Hummingbird 2 (HB2) cipher. On-sensor data compression is applied to minimize communication energy. Experimental data show performance and energy balance of the ANT-based sensor interface and quantify the HB2 encryption overhead.
An easy-to-implement numerical simulation method for adhesive contact problems involving asymmetric adhesive contact (2011)

A novel numerical method to solve asymmetric adhesive contact problems in rectangular coordinates has been developed. Surface interaction is modelled using an interface potential, deformation is coupled using Green's functions for a half space, and the resulting system of equations is solved by a relaxation technique. The method can handle arbitrary surface topography and properties. Compared with previous methods, this numerical scheme is much easier to implement and is just as accurate. Here, it is applied to two adhesive contact problems: one between a sphere and a cylinder; and the other between two identical cylinders in oblique contact. The numerical results reveal inaccuracies in elliptical contact theory when the skew angles between the two cylinders are small and the resulting contact is highly eccentric. The pull-off forces show an indiscernible decrease with decreasing value of the skew angle, which is quite different from the elliptical JKR theory. This technique can be used to solve adhesive contact problems that involve partial contact or complex geometry, such as rippled or rough surfaces.
Phomol, a New Antiinflammatory Metabolite from an Endophyte of the Medicinal Plant Erythrina crista-galli. (2005)

For Abstract see ChemInform Abstract in Full Text.
The balbiani body and the concept of physiological amyloids (2016)

Amyloids (insoluble β-sheet polymers) and prions (proteinaceous infectious particles) have long been known for their roles in neurodegenerative diseases such as Parkinson Disease (PD) and Alzheimer...
A numerical study on the influence of the amount of internal fuel in a bird strike test for the external auxiliary fuel tank of rotorcraft (2017)

The main function of an aircraft fuel tank is fuel storage, but in an urgent situation, such as a crash, the integrity of the fuel tank is directly related to the survivability of the crew. Particularly, when the external fuel tank of the aircraft leaks due to a bird-strike, it is a serious threat to the survivability of the crew. For this reason, when an auxiliary fuel tank is installed outside the aircraft for the purpose of extending the range, robustness against bird-strikes must be demonstrated. The purpose of this study is to reveal the most vulnerable conditions using bird-strike tests. Numerical analysis is carried out using crash simulation commercial software (LS-DYNA) to analyse the influence of a bird-strike on a composite container used as an external auxiliary fuel tank. For the numerical simulation, the structure is modelled as a shell element and the fluid and bird are modelled using a particle method. Using numerical analysis, we calculate the maximum stress and failure index of the composite container in each analysis scenario. Finally, we propose the most vulnerable conditions from bird-strikes after a comparison of the results of each analysis condition.
Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density (2019)

Regulation of plasma membrane curvature and composition governs essential cellular processes. The material property of bending rigidity describes the energetic cost of membrane deformations and depends on the plasma membrane molecular composition. Because of compositional fluctuations and active processes, it is challenging to measure it in intact cells. Here, we study the plasma membrane using giant plasma membrane vesicles (GPMVs), which largely preserve the plasma membrane lipidome and proteome. We show that the bending rigidity of plasma membranes under varied conditions is correlated to readout from environment-sensitive dyes, which are indicative of membrane order and microviscosity. This correlation holds across different cell lines, upon cholesterol depletion or enrichment of the plasma membrane, and variations in cell density. Thus, polarity- and viscosity-sensitive probes represent a promising indicator of membrane mechanical properties. Additionally, our results allow for identifying synthetic membranes with a few well defined lipids as optimal plasma membrane mimetics.
Instabilities in Parallel Channel of Forced-Convection Boiling Upflow System, (V) (1983)

The density wave instability in a parallel boiling channel system heated electrically has been studied experimentally and analytically by the authors. In our country, the steam generator for LMFBR has been investigated with Power Reactor and Nuclear Fuel Development Corp. as the central figure for its development, and many results of this instability were reported. Their results were different from our ones as regard to the governing factor of the period of flow oscillation in the unstable region and to the effect of the slip ratio on the stability in analysis. A new linear analytical model is proposed in this paper and the analytical results are compared with ones of two-phase analyses based on the same linear method as this model. Subsequently, the effect of the slip ratio on the stability is studied analytically by this model. The parallel boiling channel system is studied experimentally and analytically, using Freon-113 as test fluid heated by hot water as simulation of the SG for LMFBR. The governing factor of the period of flow oscillation is made clear.
Supplementary Table 3 from Pharmacologic Unmasking of Epigenetically Silenced Genes in Breast Cancer (2023)

Supplementary Table 3 from Pharmacologic Unmasking of Epigenetically Silenced Genes in Breast Cancer
Design of Mechanically Reliable ULK Glasses (2020)

We show that hyperconnected ULK dielectric glasses incorporating optimal precursor geometries lead to exceptional mechanical stiffness, as well as increasing fracture bond density. Using molecular dynamics and a novel graph theory approach, we predict that hyperconnected precursors with cyclic planar geometries significantly improve the mechanical reliability of these otherwise fragile materials, by not only increasing the network stiffness but also contributing to the fracture energy. Ultimately, we conclude that characterizing the implications of structural elements, such as precursor geometry and network connectivity, on the mechanical and fracture properties is essential for mechanically much more reliable design and integration of ULK dielectric materials.
Basophil activation testing, IgG, and IgG4 in the diagnosis of dog allergy in children with and without a dog at home (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Spectral and temporal characteristics of aerosol optical depth over a wet tropical location in north east India (2004)

Abstract A network of multi wavelength solar radiometer (MWR) stations has been in operation since the 1980s in India for measurement of aerosol optical depth (AOD). This network was augmented recently with the addition of a large number of stations located across the length and breath of India covering a variety of climate regimes. The spectral and temporal variations of aerosol optical depths observed over Dibrugarh located in the North East of India (27.3°N, 94.5°E) are investigated by analyzing the data obtained from a MWR during October 2001–September 2003 using the Langley technique. AOD varies with time of the day, month of the year and season. From January to April and October to December, aerosol optical depth decreases with wavelength whereas during May–September aerosol optical depth has been found to be nearly independent of wavelengths. AOD is higher during pre-monsoon season (March–May) and lower in the monsoon (June–September) season at about all wavelengths. The temporal variation of AOD over Dibrugarh have also been compared with those reported from selected locations in India.
A Soluble Equivalent of the Supramolecular, Quasi-One-Dimensional, Semiconducting Magnus' Green Salt (2002)

A soluble supramolecular, quasi-one-dimensional semiconducting complex comprising alternately stacked [Pt(NH2dmoc)4]2+ and [PtCl4]2- units, where dmoc denotes (S)-3,7-dimethyloctyl, has been synthesized and characterized with various methods. In contrast to earlier enunciated expectations and unlike nearly all other known derivatives, [Pt(NH2dmoc)4][PtCl4] showed the color of Magnus' green salt, [Pt(NH3)4][PtCl4], which is characteristic for linearly arranged platinum atoms with considerable Pt−Pt interactions. The Pt−Pt distance in [Pt(NH2dmoc)4][PtCl4] was established to be 3.1 Å from powder X-ray and electron diffraction patterns. Similar to Magnus' green salt, [Pt(NH2dmoc)4][PtCl4] was found to be a semiconductor with a thermal activation energy of 0.24 eV and an electrical conductivity of 1.6 × 10-7 S/cm at room temperature. Although Magnus' green salt virtually is intractable, [Pt(NH2dmoc)4][PtCl4] was soluble in common organic solvents. Remarkably, strong evidence indicated that self-assembled platinum chain structures were present also in solution. Hence, [Pt(NH2dmoc)4][PtCl4] may indeed be regarded as a processible form of Magnus' green salt.
Investigations of folded waveguide TWT oscillators for THz radiation (2004)

In this paper we are investigating folded waveguide traveling wave tubes (FWGTWT). These FWGTWTs combine the power density and high frequency advantages of vacuum microelectronics with the powerful microfabrication methods of MEMS and solid state electronics. Experimental, theoretical and computer simulation investigations of a FWGTWT oscillator have been performed, including microfabrication tests of a variety of methods.
Doping dependence of the upper critical field and Hall resistivity ofLaFeAsO1−xFx(x=0, 0.025, 0.05, 0.07, 0.11, and 0.14) (2009)

The electrical resistivity $({\ensuremath{\rho}}_{xx})$ and Hall resistivity $({\ensuremath{\rho}}_{xy})$ of ${\text{LaFeAsO}}_{1\ensuremath{-}x}{\text{F}}_{x}$ have been measured over a wide fluorine-doping range $0\ensuremath{\le}x\ensuremath{\le}0.14$ using 60 T pulsed magnets. While the superconducting phase diagram $({T}_{c},x)$ displays the classic dome-shaped structure, we find that the resistive upper critical field $({H}_{c2})$ increases monotonically with decreasing fluorine concentration, with the largest ${H}_{c2}\ensuremath{\ge}75\text{ }\text{T}$ for $x=0.05$. This is reminiscent of the composition dependence in high-${T}_{c}$ cuprates and might correlate with opening of a pseudogap in the underdoped region. Furthermore, the temperature dependence of ${H}_{c2}(T)$ for superconducting samples can be understood in terms of multiband superconductivity. ${\ensuremath{\rho}}_{xy}$ data for nonsuperconducting samples show nonlinear field dependence, which is also consistent with a multicarrier scenario.
Purified Bacillus anthracis Lethal Toxin Complex Formed in Vitro and during Infection Exhibits Functional and Biological Activity (2005)

Anthrax protective antigen (PA, 83 kDa), a pore-forming protein, upon protease activation to 63 kDa (PA(63)), translocates lethal factor (LF) and edema factor (EF) from endosomes into the cytosol of the cell. The relatively small size of the heptameric PA(63) pore (approximately 12 angstroms) raises questions as to how large molecules such as LF and EF can move through the pore. In addition, the reported high binding affinity between PA and EF/LF suggests that EF/LF may not dissociate but remain complexed with activated PA(63). In this study, we found that purified (PA(63))(7)-LF complex exhibited biological and functional activities similar to the free LF. Purified LF complexed with PA(63) heptamer was able to cleave both a synthetic peptide substrate and endogenous mitogen-activated protein kinase kinase substrates and kill susceptible macrophage cells. Electrophysiological studies of the complex showed strong rectification of the ionic current at positive voltages, an effect similar to that observed if LF is added to the channels formed by heptameric PA(63) pore. Complexes of (PA(63))(7)-LF found in the plasma of infected animals showed functional activity. Identifying active complex in the blood of infected animals has important implications for therapeutic design, especially those directed against PA and LF. Our studies suggest that the individual toxin components and the complex must be considered as critical targets for anthrax therapeutics.
Quantification of Halide in Ionic Liquids Using Ion Chromatography (2004)

The determination of chloride impurities in ionic liquids using ion chromatography is described. A wide range of cation-anion combinations may be analyzed using ion chromatography, including water-immiscible ionic liquids. For all ionic liquids studied, the limit of quantification for chloride was found to be below 8 ppm.
Stability of rate and power control algorithms in wireless cellular networks (2011)

In radio resource management for cellular networks a trade-off has to be made between the congestion level, related to cell coverage and intercell interference, and the Quality of Service (QoS) or data rates of the users. This is implemented by using a fast inner power control loop and an outer rate control algorithm, working on a slower time scale.
Caspase-3 and -8 Activation and Cytokine Removal with a Novel Cellulose Triacetate Super-Permeable Membrane in an in Vitro Sepsis Model (2003)

Pro-apoptotic molecules are generated during sepsis which may be responsible for alteration of organ function in sepsis. Removal of systemic apoptotic activity may affect recovery from sepsis. Current high flux membranes might not be sufficiently permeable to eliminate pro-apoptotic factors. We evaluated the elimination of pro-apoptotic factors induced by LPS in human whole blood by a super-permeable cellulose triacetate membrane (SUREFLUX FH 150, Nipro, Osaka, Japan) in comparison to a standard high flux cellulose triacetate membrane (UT 700, Nipro, Osaka, Japan) and a polyethersulfone plasmafilter (Bellco, Mirandola Italy) in an in vitro blood circulation. We spiked human whole blood with lipopolysaccharide from Escherichia coli (Serotype 026-86, 10 mg/ml), incubated it for 3 hours to allow cytokine generation and recirculated it at 300 ml/min for 3 hours. The UF line was first returned to the blood module at 10 min. After this, the UF was drained from 10 to 60 min at a rate of 1000 ml/h. Zero balance was obtained by re-infusion of bicarbonate buffered hemofiltration fluid. Apoptosis was assessed on U937 monocytes (incubated with plasma or ultrafiltrate) by fluorescence microscopy dyes (Hoechst 33342, propidium iodide) and annexin V flow cytometry. Caspase-3 and Caspase-8 activity was assessed on the recirculated blood monocytes by spectrophotometric methods. IL-2, IL-10 and TNFalpha were determined by commercially available ELISAs. Sieving coefficients and clearances were determined for the different cytokines. Caspase-3 and Caspase-8 were activated by LPS and remained either stable or increased during in vitro circulation. Apoptosis activity of U937 cells, when incubated with the ultrafiltrate, increased in parallel with arterial plasma values (for Uf: UT700 = 23.1%; Sureflux FH150 = 42.5%). However, by 60 min the apoptotic activity recorded with the ultrafiltrate was reduced to the levels of arterial plasma (for Uf: UT700 = 19.8%; Sureflux FH150 = 11.2%). Sieving coefficients in the super-permeable membrane were significantly higher for all measured cytokines in comparison to the standard high flux membrane (e.g. TNFalpha 0.72 vs 0.03 p < 0.001) and close to the values observed for the plasmafiltration membrane. Nevertheless protein losses measured by albumin leakage were much lower with the Sureflux filter in comparison to the plasmafilter. In conclusion, pro-apoptotic factors can be eliminated by dialytic membranes with the removal rate maximized by using super high flux dialysers which may represent a compromise between hemofiltration and plasmafiltration membranes.
MR Elastography of the Liver: Defining Thresholds for Detecting Viscoelastic Changes (2013)

Purpose To define thresholds for detecting significant change in liver viscoelasticity with magnetic resonance (MR) elastography, both for whole-liver measurements and for voxel-wise measurements in relation to spatial resolution. Materials and Methods This prospective study was approved by the institutional review board, and all participants provided written informed consent. Thirty participants (16 volunteers and 14 patients with hepatitis B or C; 18 men; median age, 30.4 years; age range, 18.9–58.6 years) underwent imaging twice while in the same position (intraimage reproducibility), after repositioning (within-day reproducibility), and 1–4 weeks later (between-weeks reproducibility). MR elastography parameters comprised elasticity, viscosity, attenuation parameter α, and propagation parameter β. Bland-Altman analysis was used to calculate repeatability indexes for each parameter. Analyses were performed in a region-of-interest and a voxel-by-voxel level. Voxel-wise results were calculated in relation to spatial resolution by applying Gaussian filtering to establish the optimal trade-off point between resolution and reproducibility. Results For elasticity, α, and β, within-day and between-weeks results were significantly lower than intraimage results (P ≤ .018 for all). Within-day and between-weeks results did not differ significantly. Over-time changes of more than 22.2% for elasticity, 26.3% for viscosity, 26.8% for α, and 10.1% for β represented thresholds for significant change. The optimal trade-off between spatial resolution and reproducibility was found at a filter size of 8-mm full width at half maximum (FWHM) for elasticity and propagation parameter β and at 16-mm FWHM for viscosity and attenuation parameter α. Conclusion Repositioning causes a significant decrease in the reproducibility of MR elastography. The propagation parameter β is the most reliable parameter, with an over-time threshold for significant change of 10.1% and the ability to reproduce viscoelasticity up to a resolution of 8-mm FWHM. ©RSNA, 2013 Online supplemental material is available for this article.
ChemInform Abstract: A General Stereocontrolled Synthesis of cis‐2,3 Disubstituted Pyrrolidines and Piperidines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.