gebhart/patrepeval huggingface dataset:
Development and Characterization of a Simian Virus 40 Immortalized Bovine Endometrial Stromal Cell Line (2008)

In ruminants, interferon-tau (IFNtau) is the maternal recognition signal inhibiting prostaglandin (PG) F2alpha production by endometrial epithelial cells and stimulating interferon-stimulated genes in the stroma. Stromal cells mediate the action of progesterone on epithelial cells during pregnancy. Our working hypothesis is that IFNtau acts as a molecular switch that turns on PGE(2) production in endometrial stromal cells while suppressing PGF2alpha production from epithelial cells. In this report we document immortalization and functional characterization of a bovine stromal cell line from the caruncular region of the endometrium [caruncular stromal cell (CSC)]. Primary stromal cells were immortalized by nucleofection with simian virus 40 large T antigen and integrase. The resulting cell line, CSC, expresses stromal cell-specific vimentin, estrogen, and progesterone receptors, and is amenable for transient transfection. Basal and stimulated production of PGE2 is higher than PGF2alpha and associated with cyclooxygenase (COX) 2 expression. Phorbol myristate acetate (PMA) and IFNtau up-regulate COX2 and PG production in a dose-dependent manner. When added together, low concentrations of IFNtau inhibit PMA-induced COX2 expression; whereas this inhibition is lost at high concentrations. Expression of signal transducer and activator of transcription 1 is induced by IFNtau at all concentrations studied but is not modulated by PMA. Because expression of signal transducer and activator of transcription 1 does not exhibit the biphasic response to IFNtau, we investigated the p38 MAPK pathway using the selective inhibitor SB203580. Inhibition of the p38 MAPK pathway abolishes IFNtau action on PG production. In summary, CSC appears as a good stromal cell model for investigating the molecular mechanisms related to IFNtau action and PG production in the bovine.
The Renaissance of the West: How Europe and America Can Shape up in Confronting Putin's Russia (2015)

The West is facing challenges on many fronts. There has been crisis after crisis in the EU’s eastern and southern neighbourhoods. Terrorist movements are gaining traction in the Middle East. Authoritarian regimes are threatening the core values of the West, and even its cohesion—and no regime more so than the newly aggressive and fundamentally antagonistic Russia. This research paper argues that by countering the threat posed by Putin’s Russia, we can achieve a stronger transatlantic relationship. This will ultimately lead to a Renaissance of the West and reinforce the global liberal order.
Fabrication of Wound Capacitors Using Flexible Alkali-Free Glass (2016)

Alkali-free glasses, which exhibit high energy storage densities ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim 35$ </tex-math></inline-formula> J/cc), present a unique opportunity to couple high temperature stability with high breakdown strength, and thus provide an avenue for capacitor applications with stringent temperature and power requirements. Realizing the potential of these materials in kilovolt class capacitors with >1 J/cc recoverable energy density requires novel packaging strategies that incorporate these extremely fragile dielectrics. In this paper, we demonstrate the feasibility of fabricating wound capacitors using 50- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> -thick glass. Two capacitors were fabricated from 2.8-m-long ribbons of thin (50 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> ) glass wound into 125–140-mm-diameter spools. The capacitors exhibit a capacitance of 70–75 nF with loss tangents below 1%. The wound capacitors can operate up to 1 kV and show excellent temperature stability to 150 °C. By improving the end terminations, the self-resonance can be shifted to above 1 MHz, indicating that these materials may be useful for pulsed power applications with microsecond discharge times.
Transcriptional activity and epigenetic regulation of transposable elements in the symbiotic fungus Rhizophagus irregularis (2021)

Arbuscular mycorrhizal (AM) fungi form mutualistic relationships with most land plant species. AM fungi have long been considered as ancient asexuals. Long-term clonal evolution would be remarkable for a eukaryotic lineage and suggests the importance of alternative mechanisms to promote genetic variability facilitating adaptation. Here, we assessed the potential of transposable elements for generating such genomic diversity. The dynamic expression of TEs during <i>Rhizophagus irregularis</i> spore development suggests ongoing TE activity. We find <i>Mutator</i>-like elements located near genes belonging to highly expanded gene families. Whole-genome epigenomic profiling of <i>R. irregularis</i> provides direct evidence of DNA methylation and small RNA production occurring at TE loci. Our results support a model in which TE activity shapes the genome, while DNA methylation and small RNA-mediated silencing keep their overproliferation in check. We propose that a well-controlled TE activity directly contributes to genome evolution in AM fungi.
Deadline‐aware TCP congestion control for HTTP adaptive streaming services (2018)

Summary Over the last decades, video streaming services have gained a lot of popularity, representing over 70% of the total consumer Internet traffic worldwide. While originally dedicated streaming protocols have been used to deliver these services, for several years, the video streaming industry is steadily shifting to HTTP adaptive streaming (HAS)–based delivery over TCP. With each video segment, implicit delivery deadlines are associated in order to avoid playout interruptions. However, TCP is known to be far from minimizing the number of deadline‐missing streams. In this paper, 2 deadline‐aware congestion control mechanisms are proposed, based on a parametrization of the traditional TCP New Reno congestion control strategy. By introducing deadline awareness at the transport layer, the modulation of the congestion window size is dynamically adapted to steer the aggressiveness of the considered stream to optimize the delivery of video streaming services. The proposed approaches are thoroughly evaluated in an HAS video‐on‐demand scenario over tree‐based delivery networks. It was shown that in a realistic scenario, the proposed approaches can outperform traditional congestion control strategies by up to 12% in terms of estimated mean opinion score, mainly by reducing the average video freezing time by more than 85%.
Integrated Data Mapping Engine (DaME) for Financial Services (2022)

Enterprise organizations have vast datasets that need comprehensive analysis on a frequent basis, in order to manage data and take business decisions based on it. However, we observe that there can be a lack of industry standards for definitions of key terms. Additionally, there is a lack of governance for maintaining business processes. This typically leads to disconnected siloed datasets generated from disintegrated systems. To address these challenges, we developed a novel, integrated methodology DaME (Data Mapping Engine) that performs data mapping using ensemble of NLP techniques.The results from the industrial application and evaluation of DaME on a financial services dataset are encouraging that it can help reduce manual effort by automating data mapping and reusing the learning. The accuracy from our dataset in the application is much higher at 69% compared to the existing state-of-the-art with an accuracy of 34%. It has also helped improve the productivity of the industry practitioners, by saving them 14,000 hours of time spent manually mapping vast data stores over a period of ten months.
Pro-angiogenic and Anti-inflammatory Regulation by Functional Peptides Loaded in Polymeric Implants for Soft Tissue Regeneration (2012)

Inflammation and angiogenesis are inevitable in vivo responses to biomaterial implants. Continuous progress has been made in biomaterial design to improve tissue interactions with an implant by either reducing inflammation or promoting angiogenesis. However, it has become increasingly clear that the physiological processes of inflammation and angiogenesis are interconnected through various molecular mechanisms. Hence, there is an unmet need for engineering functional tissues by simultaneous activation of pro-angiogenic and anti-inflammatory responses to biomaterial implants. In this work, the modulus and fibrinogen adsorption of porous scaffolds were tuned to meet the requirements (i.e., ~100 kPa and ~10 nm, respectively), for soft tissue regeneration by employing tyrosine-derived combinatorial polymers with polyethylene glycol crosslinkers. Two types of functional peptides (i.e., pro-angiogenic laminin-derived C16 and anti-inflammatory thymosin β4-derived Ac-SDKP) were loaded in porous scaffolds through collagen gel embedding so that peptides were released in a controlled fashion, mimicking degradation of the extracellular matrix. The results from (1) in vitro coculture of human umbilical vein endothelial cells and human blood-derived macrophages and (2) in vivo subcutaneous implantation revealed the directly proportional relationship between angiogenic activities (i.e., tubulogenesis and perfusion capacity) and inflammatory activities (i.e., phagocytosis and F4/80 expression) upon treatment with either type of peptide. Interestingly, cotreatment with both types of peptides upregulated the angiogenic responses, while downregulating the inflammatory responses. Also, anti-inflammatory Ac-SDKP peptides reduced production of pro-inflammatory cytokines (i.e., interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor alpha) even when treated in combination with pro-angiogenic C16 peptides. In addition to independent regulation of angiogenesis and inflammation, this study suggests a promising approach to improve soft tissue regeneration (e.g., blood vessel and heart muscle) when inflammatory diseases (e.g., ischemic tissue fibrosis and atherosclerosis) limit the regeneration process.
The Hidden Costs and Characteristics of Childhood Rotavirus Emergency Visits in Canada (2011)

Both the pre- and postvisit costs contribute substantially to the societal costs associated with an ED visit for rotavirus infection. In Canada, we estimate that the annual healthcare cost for children requiring a rotavirus ED visit ranges from $4.5 to $9.3 million, but when parental costs are included, the total societal cost ranges from $8.9 to $18.4 million.
Intramolecular thermolytic carbon-hydrogen activation processes. Solid-state structural characterization of a mononuclear .eta.6-Me4C5CH2 zirconium complex and a mechanistic study of its formation from (Me5C5)2Zr(C6H5)2 (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular thermolytic carbon-hydrogen activation processes. Solid-state structural characterization of a mononuclear .eta.6-Me4C5CH2 zirconium complex and a mechanistic study of its formation from (Me5C5)2Zr(C6H5)2Laurel E. Schock, Carolyn P. Brock, and Tobin J. MarksCite this: Organometallics 1987, 6, 2, 232–241Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://doi.org/10.1021/om00145a003RIGHTS & PERMISSIONSArticle Views387Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Optical and RF stability transfer in a monolithic coupled-cavity colliding pulse mode-locked quantum dot laser (2012)

We report a novel quantum dot based laser design where a stable high-Q master laser is used to injection lock a passively mode-locked monolithic colliding pulse slave laser. Coupling between the crossed orthogonal laser cavities is achieved through a common monolithically integrated saturable absorber, which results in the locking and hence reduction of the timing jitter as well as the long-term frequency drift of the slave laser. A stable 30 GHz optical pulse train is generated with more than 10 dB reduction in the RF noise level at 20 MHz offset and close to 3 times reduction in the 10 dB average optical linewidth of the slave laser.
Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens (2022)

Abstract Interstitial lung disease (ILD), a group of disorders characterized by scarring of the lungs, often leads to fatal impairment of respiratory function. While some patients exhibit features of autoimmunity, the role of the immune system within this heterogeneous group of disorders remains a matter of debate. We previously reported the enlargement of lung-draining lymph nodes (LLN) correlates with decreased survival in ILD patients, suggesting that activation of the adaptive immune system may contribute to pathophysiology. To investigate the composition and functional state of cells in the enlarged LLN, we performed flow cytometry analysis of LLN cells from endstage ILD patients undergoing transplantation (n=53) and control organ donors (n=36). We found that T cells from the ILD LLN exhibit effector memory phenotypes and significantly upregulate activation molecules including HLA-DR, CD38, CD154 and CD137, which are indicative of an ongoing immune response. Analyses of CD4 T cells revealed that Foxp3+CD25− regulatory T cells are specifically increased in ILD LLN. Moreover, follicular helper T cells and germinal center (GC) B cells are highly enriched, suggesting that antibody responses are activated in ILD LLN. To test the hypothesis that autoantigens may drive the augmented GC response, we screened circulating antibodies from ILD patients at two medical centers against the entire human peptidome using phage immunoprecipitation sequencing. We defined novel and shared autoantigens and experimentally validated antibody bindings to 5 protein antigens. Collectively, our findings suggest that antigen-specific immune responses may be involved in the pathophysiology and identify novel autoantigens for subsets of ILD.
Soluble fullerene derivatives: The effect of electronic structure on transistor performance and air stability (2011)

The family of soluble fullerene derivatives comprises a widely studied group of electron transporting molecules for use in organic electronic and optoelectronic devices. For electronic applications, electron transporting (n-channel) materials are required for implementation into organic complementary logic circuit architectures. To date, few soluble candidate materials have been studied that fulfill the stringent requirements of high carrier mobility and air stability. Here we present a study of three soluble fullerenes with varying electron affinity to assess the impact of electronic structure on device performance and air stability. Through theoretical and experimental analysis of the electronic structure, characterization of thin-film structure, and characterization of transistor device properties we find that the air stability of the present series of fullerenes not only depends on the absolute electron affinity of the semiconductor but also on the disorder within the thin-film.
Passive acoustic mapping using optimal beamforming for real-time monitoring of ultrasound therapy (2013)

In ultrasound therapy, passive acoustic mapping (PAM) has been shown to be an effective method for imaging the acoustic emissions generated during treatment providing the potential for real-time therapy monitoring. In both high intensity ultrasound (HIFU) ablative surgery and targeted drug delivery, imaging artifacts at higher amplitude exposure conditions have been observed, which make the localization and dosimetry of therapeutically relevant cavitation activity a challenge. Due to these artifacts, correlating drug release or lesion volumes to the PAMs is hindered for many exposures. It is proposed that incorporating optimal beamforming techniques into the PAM framework can reduce and remove these artifacts, allowing determination of the extent of cavitation activity during ultrasound therapy. Additionally, optimal beaforming is found to yield improved resolution, good interference suppression, and robustness against steering vector errors. A description of the origin of the artifacts as well as reduction of them by implementing optimal beamforming within PAM will be demonstrated in the context of targeted drug delivery.
In vitro irradiation of infected root canals with a diode laser: results of microbiologic, infrared spectrometric, and stain penetration examinations. (1997)

This study aimed to examine the suitability of the diode laser with a wavelength of 810 nm for reducing bacteria in root canals. Forty-four extracted, endodontically prepared teeth were inoculated with Escherichia coli and Streptococcus faecalis. No bacterial growth was observed when the teeth were irradiated at an output power of 4 W and a pulse rate of 10 milliseconds, with breaks of 10 milliseconds between the irradiations. Exposure time was five times 5 seconds. Infrared spectroscopic examinations revealed that irradiation at 4 W under even circling movements resulted in a maximum rise in temperature of 6 degrees C on the root surface. Stain penetration tests and scanning electron microscopic examinations revealed complete closure of the dentinal tubules on the irradiated root canal walls.
Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells (2011)

Our findings indicate that these rapamycin-treated T cells may represent a unique cell model for identifying nutrients and signals critical to regulating metabolism in both effector and memory T cells, and for the development of new methods to improve the efficacy of adoptive T cell cancer therapy.
Polygonic representation of Explicit Model Predictive Control (2013)

The paper proposes to reduce complexity of explicit MPC feedback laws by representing regions over which the law is defined as (possibly non-convex) polygons. Each polygon is then represented only by its boundaries, which reduces the memory footprint of the feedback law. Even though significant amount of memory can be saved this way, the price to be paid is increased computational load associated by performing point location tasks in non-convex objects. Therefore we propose to devise inner and outer convex approximations of non-convex polygons to reduce the computational requirements. Such approximations allow to perform point location more effectively, leading to a reduction of the required on-line computational effort. Several ways to design suitable approximations are presented and efficacy of the proposed procedure is evaluated.
An effective algorithm for parallelizing hash joins in the presence of data skew (2002)

A parallel hash join algorithm based on the concept of hierarchical hashing is proposed to address the problem data skew. The proposed algorithm adds an extra scheduling phase to the usual hash and join phases. During the scheduling phase, a heuristic optimization algorithm, using the output of the hash phase, attempts to balance the load across the multiple processors in the subsequent join phase. The algorithm naturally identifies the hash partitions with the largest skew elements, splits them up, and assigns each of them to an optimal number of processors. Assuming a Zipf-like distribution of the elements in the join column, the algorithm is shown to achieve good load balancing for the join phase in a CPU-bound environment, and it is shown to be fairly robust relative to the degree of data skew and the total number of processors. The overall speedup due to this algorithm is compared with conventional parallel hash join methods and the considerable advantage of the proposed method is demonstrated even when the additional scheduling phase is taken into account.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Glass/metal interactions, leaching, waste glass, canister material (1985)

Cellular response to NCC exposure was very comparable, particularly concerning oxidative stress response, inflammation, cell cycle/proliferation, and apoptosis. In this cellular response, Nfr2 was highly centralized and participated in several multifunctional protein complexes, including several related to ER-stress. These results add evidence on the possible Ni<sup>2+</sup> induced - ER stress mainly associated with insoluble NCC. In this scenario, we also show how protein degradation mediated by ubiquitination seems to play key roles in cellular responses to Ni.
0.25-μm logic manufacturability using practical 2D optical proximity correction (1998)

Simplified 2-D Optical Proximity Correction (OPC) algorithms have been devised, calibrated and implemented on a state-of- the-art 0.25 micrometer random logic process in order to reduce metal line pullback on critical layers. The techniques used are rules-based, but are characterized by fast and robust data conversion algorithms, calibrations based on actual process data improvements in reticle manufacturability, and inspectability of the resultant OPC corrected reticles. Application to local interconnect and metal patterning has corrected fundamental yield-limiting mechanisms in these levels.
Carrier transport in dichromatic color-coded semipolar (2021) and (2021) III-N LEDs (2014)

Simulation of III-nitride color-coded multiple quantum well (MQW) LED structures was performed using as an experimental benchmark dichromatic semipolar LEDs grown in Ga-polar and N-polar crystallographic orientations (Y. Kawaguchi et.al, APL 100, 231110, 2012). Different QW depths in the color-coded LEDs and opposite interface polarization charges in Ga-polar and N-polar structures provide different conditions for carrier transport across the LED active regions. Combination of several effects was crucial for adequate reproduction of the emission spectra experimentally observed in color-coded structures with violet-aquamarine and aquamarine-violet active region layouts. A standard drift-diffusion transport model wascompleted with rate equations for nonequilibrium QW populations and several high-energy transport features, including the effects of QW carrier overshoot and Auger-assisted QW depopulation. COMSOL-based Optoelectronic Device Modeling Software (ODMS) developed at Ostendo Technologies Inc. was utilized for device simulation.