gebhart/patrepeval huggingface dataset:
Radio-over-Fiber Systems with 1-bit Digital Modulation for 5G/6G Indoor Wireless Communication (2021)

This paper introduces the radio-over-fiber systems with the two novel 1-bit digital modulators: a phase-modulated-clocking envelope ΔΣ modulator and an all-digital outphasing modulator. By these modulators, radio-over-fiber systems are realized with commercially available optical devices for digital communication systems in low cost. The simulation results show that these modulators are verified to comply with the 3GPP ACLR specifications for 100 MHz OFDM signal.
A 14 Gb/s Directly Modulated Hybrid Microring Laser Transmitter (2018)

The first demonstration of a hybrid-integrated directly modulated microring laser transmitter operating up to 14 Gb/s operation is reported. A CMOS driver with an asymmetric 2-tap feed-forward compensates for the microring laser non-linear dynamics.
c-Kit–Positive Cardiac Stem Cells Nested in Hypoxic Niches Are Activated by Stem Cell Factor Reversing the Aging Myopathy (2013)

Our findings support the notion that strategies targeting CSC activation and growth interfere with the manifestations of myocardial aging in an animal model. Although caution has to be exercised in the translation of animal studies to human beings, our data strongly suggest that a pool of functionally competent CSCs persists in the senescent heart and that this stem cell compartment can promote myocyte regeneration effectively, partly correcting the aging myopathy.
Multiphase Flow Conditioning Using Drag-Reducing Agents (1999)

Abstract Experimental study has been performed in a 10-cm diameter, 36-m long, multiphase inclinable Plexiglass flow loop. Superficial liquid velocities between 0.5 and 3 m/s andsuperficial gas velocities between 2 and 10 m/s in 2 degree inclined pipes were examined. A 2.5 cP oil at 25 °C was used and water cut was 50%. The experiments were undertaken at a pressure of 0.13 MPa and a temperature of 25 °C with carbon dioxide as the gas. Influence of DRA on the flow characteristics such as pressure gradient, slug translational velocity, the height of the liquid film, slug frequency and Froude number using Drag Reducing Agents (DRA) has been studied. The DRA concentrations of 10 ppm and 50 ppm were used in this study. The DRA was effective in reducing the pressure gradient at all liquid and gas velocities. At a superficial liquid velocity of 1 m/s and gas velocities of 2 and 6 m/s, the pressure gradient decreased from 544 Pa/m to 377 Pa/m and from 793 Pa/m to 477 Pa/m in 2 degree upward inclination at a concentration of 50-ppm DRA. The corresponding DRA effectiveness was 31% and 40% respectively. Slug translational velocity did not change much with addition of DRA. But the slug frequency and the height of the liquid film decreased with addition of DRA, which led to a decrease in pressure gradient. At a superficial liquid velocity of 0.5 m/s and gas velocities of 2 and 8 m/s, slug frequency was reduced from 21 to 16 slugs/minute and from 18 to 14 slugs/minute in 2-degree upward flow at a DRA concentration of 50 ppm. Froude number increased with addition of DRA. At a superficial liquid velocity of 0.5 m/s and superficial gas velocity of 2 m/s, the Froude number increases from 4.7 to 6.3 when 50 ppm DRA was added.
2,6-Anhydro-1-deoxy-3,4-O-isopropylidene-3-C-methyl-β-D-ribo-hex-2-ulofuranose (2007)

The relative configuration of the title compound, C10H16O4, was firmly established by X-ray crystallographic analysis. The absolute configuration was determined by the use of 2-C-methyl-d-ribono-1,4-lactone as the starting material.
Proneurotensin Predicts Cardiovascular Disease in an Elderly Population (2018)

In the elderly population, proneurotensin independently predicts development of CVD in both genders, whereas it only predicts diabetes in women.
Numerical simulation of mow strip subcomponents used with strong post guardrail systems (2005)

Abstract Pavement mow strips are being used to combat vegetation growth around guardrail posts. However, the effect of pavement post encasement on the crashworthiness of strong post guardrail systems has not been investigated. In this paper, results from numerical simulation of mow strip subcomponents are compared with field experimental testing. Mow strip dimensions, materials, and depths are considered in addition to the presence of ‘leave-out’ sections around posts. Wood and steel guardrail posts embedded in various mow strip systems and confinement conditions were subjected to dynamic impact testing with a bogie vehicle. Results from these tests are compared with numerical simulations carried out using the nonlinear, dynamic, finite-element analysis code LS-DYNA. Results of simulation indicate that most of the subcomponent models can be used with confidence in design of mow strip barriers for vehicle impact.
P-145 WELCOME 54-week Open-label Extension (2014)

Studies have suggested that patients with Crohn’s disease who respond to infliximab (IFX) then lose response may benefit from switching to another TNF antagonist. The WELCOME study (NCT00308581) assessed clinical response and remission at six weeks with certolizumab pegol (CZP) treatment in patients who previously responded to IFX and then lost response. Here, we present clinical response and remission data at 1.5 years in patients from the WELCOME open-label extension study (NCT00333788) according to baseline antibody to infliximab (ATI) status. In the WELCOME study, patients with secondary failure of IFX or adverse events with IFX (N=539) were treated with CZP 400 mg every 2 weeks at weeks 0, 2, and 4. At Week 6, responders (ΔCDAI ≥100) were randomized to CZP 400 mg either every 2 weeks or every 4 weeks for 26 weeks. After 26 weeks, patients who maintained clinical response (ΔCDAI ≥70) were given the opportunity to continue in the WELCOME open-label extension study with CZP 400 mg every 4 weeks up to an additional 54 weeks (total study time, 1.5 years). The primary outcomes include response (ΔCDAI ≥100 points) and remission (CDAI score ≤150). In this analysis, outcomes were studied at Week 54 of the open-label extension study in subsets of patients that were grouped by ATI status. Safety was monitored throughout. Of the 201 participants in the open-label extension study, 94 (47%) were positive for ATIs and 107 (53%) were negative; the mean age was 39 ± 12.1 years (ATI positive) and 38 ± 11.1 (ATI negative). At Week 54, for observed cases, 80%/59% (ATI positive/negative, respectively, p=0.04) of patients maintained response (ΔCDAI ≥100 points), and 63%/56% (p=ns) maintained remission (Table). Adverse events occurred in 87%/93% and serious adverse events occurred in 16%/17% of patients. Clinically important adverse events, including injection site reactions, arthropathies, gastrointestinal events and immune disorders were similar between the two groups (data not shown). No deaths were recorded. Patients who experienced secondary failure of IFX treatment were able to maintain response and remission during 1.5 years of treatment with CZP, irrespective of their ATI status. The incidence of adverse events was similar to previous studies. These data suggest that CZP is a good long-term treatment alternative for patients who had secondary failure of IFX treatment and are ATI positive.
Technology Area Roadmap for In Space Propulsion Technologies (2010)

This slide presentation reviews the technology area (TA) roadmap to develop propulsion technologies that will be used to enable further exploration of the solar system, and beyond. It is hoped that development of the technologies within this TA will result in technical solutions that will improve thrust levels, specific impulse, power, specific mass, volume, system mass, system complexity, operational complexity, commonality with other spacecraft systems, manufacturability and durability. Some of the propulsion technologies that are reviewed include: chemical and non-chemical propulsion, and advanced propulsion (i.e., those with a Technology Readiness level of less than 3). Examples of these advanced technologies include: Beamed Energy, Electric Sail, Fusion, High Energy Density Materials, Antimatter, Advanced Fission and Breakthrough propulsion technologies. Timeframes for development of some of these propulsion technologies are reviewed, and top technical challenges are reviewed. This roadmap describes a portfolio of in-space propulsion technologies that can meet future space science and exploration needs.
Hyperfractionated/accelerated thoracic radiation therapy (HFXRT) increased survival compared to daily RT (QDRT) for limited small cell lung cancer (LSCLC) with Concurrent Chemotherapy (ChT) (2005)

7158 Background: HFXRT has not been commonly used in community practice despite better 5-yr survival compared to QDRT with concurrent cisplatin and etoposide by randomized study. Methods: CT-staged LSCLC pts treated by HFXRT or QDRT with cisplatin-based ChT between 1985–1998 were reviewed. Complete responders received prophylactic cranial irradiation (PCI). The data were analyzed by Kaplan-Meier survival function and the Log Rank test. Results: 324 pts were treated and followed from 3–156M (median 47M). Median age: 60. Male (53%), KPS 90–100 (71%), wt loss <5% (80%). Pleural effusion (PE) in 24%. 217 received QDRT: median dose 50Gy/5W. 107 received HFXRT: median dose 45Gy/3W. 168 received PCI: 108 in QD group and 60 in HFXRT group. 5 yr-OS: 25% by HFXRT vs 12% by QDRT (p=0.02). In PCI pts, 5yr OS: 32.3% by HFXRT vs 18.9% by QDRT (p=0.02). MS of 24M by HFXRT vs 18M by QDRT. Acute Gr 3 esophagitis: 21.5% by HFXRT vs 9.2% QDRT (p=0.002). Gr 3 lung fibrosis: 30.8% by HFXRT vs 12.4% by QDRT (p< 0.0001). Multivariate analysis showed factors influencing OS were PCI (p=0.001), HFXRT (p<0.0001), and PE (p<0.0001). Conclusions: This retrospective study showed that OS was improved by concurrent ChT and HFXRT compared to QDRT and application of PCI. It is important to reduce normal tissue toxicities in the future when HFXRT and concurrent ChT are applied. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca MedImmune Speakers Bureau
Cleavage reaction of a synthetic oligoribonucleotide corresponding to the autocleavage site of a precursor RNA from bacteriophage T4 (1991)

A fragment (GUUUCGUACAAAC) having a consensus sequence for the self-cleavage domain in a precursor of an RNA molecule from T4-infected Escherichia coli cells (p2Sp1; precursor of species 1) was chemically synthesized and found to be cleaved either between CA (139-140) or between UA (137-138) in the presence of monovalent cations and a non-ionic detergent. The cleaved products had 5'-hydroxyl and 3'-phosphate groups, of which some were in the form 2',3'-cyclic phosphates.
Systems analysis of metabolism in platelet concentrates during storage in platelet additive solution (2018)

Platelets (PLTs) deteriorate over time when stored within blood banks through a biological process known as PLT storage lesion (PSL). Here, we describe the refinement of the biochemical model of PLT metabolism, iAT-PLT-636, and its application to describe and investigate changes in metabolism during PLT storage. Changes in extracellular acetate and citrate were measured in buffy coat and apheresis PLT units over 10 days of storage in the PLT additive solution T-Sol. Metabolic network analysis of these data was performed alongside our prior metabolomics data to describe the metabolism of fresh (days 1-3), intermediate (days 4-6), and expired (days 7-10) PLTs. Changes in metabolism were studied by comparing metabolic model flux predictions of iAT-PLT-636 between stages and between collection methods. Extracellular acetate and glucose contribute most to central carbon metabolism in PLTs. The anticoagulant citrate is metabolized in apheresis-stored PLTs and is converted into aconitate and, to a lesser degree, malate. The consumption of nutrients changes during storage and reflects altered PLT activation profiles following their collection. Irrespective of the collection method, a slowdown in oxidative phosphorylation takes place, consistent with mitochondrial dysfunction during PSL. Finally, the main contributors to intracellular ammonium and NADPH are highlighted. Future optimization of flux through these pathways provides opportunities to address intracellular pH changes and reactive oxygen species, which are both of importance to PSL. The metabolic models provide descriptions of PLT metabolism at steady state and represent a platform for future PLT metabolic research.
Morphology and Physical Properties of Binary Blend Based on PVDF and Multi‐Walled Carbon Nanotube (2007)

Abstract Semicrystalline Poly(vinylidene fluoride)(PVDF) was melt blended by multi‐ walled carbon nanotube (MWNT) at various contents (0.01 ∼ 5 wt%) using internal mixer. The relationships between morphology and physical properties based on PVDF and MWNT were investigated. As the MWNT content is increased, the apparent supercooling required for PVDF crystallization and the size of spherulites in PVDF decrease. In the WAXD profiles, the incorporation of MWNT produced a large shoulder at 2 θ = 20.7° with increasing the MWNT content, corresponding to the polar β ‐form crystal of PVDF. The experimental percolation threshold for the electrical conductivity in PVDF was estimated and clearly occured between 2 and 2.5 wt%. Similar tendency was also observed in thermal conductivity and permittivity.
Effects of vacuum ultraviolet and ultraviolet irradiation on ultrathin hafnium-oxide dielectric layers on (100)Si as measured with electron-spin resonance (2010)

The effects of vacuum ultraviolet (VUV) (7.2 eV) and UV (4.9 eV) irradiation on hafnium-oxide dielectric layers were studied with electron-spin resonance to detect defect states. Silicon dangling-bond defects (Pb centers) and positively charged oxygen vacancies (E′ centers) were detected with g-factor fitting. VUV irradiation increases the level of Pb states, while UV decreases the level of Pb states but increases the level of E′ states significantly. Rapid thermal annealing appears to mitigate these effects. Absolute values of the defect-state concentrations are presented.
Field method for monitoring blood glucose in beef cattle. (1999)

The purpose of this study was to determine the applicability of the Accu-Chek Easy (ACE) human self-monitoring system for monitoring glycemic status in cattle. The ACE method was compared with the Yellow Springs Instrument (YSI) analytical laboratory method in two studies. A preliminary study (62 samples) and a primary study (434 samples) involved a nine-fold range and a 10-fold range, respectively, of glucose concentrations obtained during the acute phase response of growing beef cattle to injections of varying dosages of endotoxin. The ACE monitoring method compared with the YSI analytical method resulted in similar patterns of glucose concentration change, similar ranking of glucose means across endotoxin dosages during hyper-and hypoglycemia, and a close relationship between paired YSI and ACE concentrations from common samples. The ACE method identified all nine animals that displayed hypoglycemic distress during the acute phase response to endotoxin injection. The relationship between the YSI analytical method and the ACE monitoring method was found to be nonlinear (YSI = -38.2+13.6.ACE.50; R2 = .99; Sy.x = 7.3 mg/dL), and the use of this equation to predict YSI values from ACE values in an independent data set resulted in linearity when YSI was regressed on the predicted YSI values (YSI = -.78+1.00. Predicted YSI; R2 = .87; Sy.x = 6.9 mg/dL). Even though variation seemed greater for ACE than for YSI, we concluded that a system developed for human self-monitoring of blood glucose, such as the ACE, can be used to monitor the glycemic status of cattle.
Optimal non‐recursive and recursive spatial filters for de‐multiple of OBS data (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002Optimal non‐recursive and recursive spatial filters for de‐multiple of OBS dataAuthors: Tage RøstenDirk‐Jan van ManenLasse AmundsenJohan RobertssonTage RøstenStatoil Research Centre, Dirk‐Jan van ManenWesternGeco Oslo Technology Center, Lasse AmundsenStatoil Research Centre, and Johan RobertssonWesternGeco Oslo Technology Centerhttps://doi.org/10.1190/1.1816817 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1816817FiguresReferencesRelatedDetailsCited byOn the use of multicomponent streamer recordings for reconstruction of pressure wavefields in the crossline directionJohan O. Robertsson, Ian Moore, Massimiliano Vassallo, Kemal Özdemir, Dirk-Jan van Manen, and Ali Özbek9 September 2008 | GEOPHYSICS, Vol. 73, No. 5Interferometric modeling of wave propagation in inhomogeneous elastic media using time reversal and reciprocityDirk-Jan van Manen, Andrew Curtis, and Johan O. Robertsson17 August 2006 | GEOPHYSICS, Vol. 71, No. 4Rough-sea deghosting of streamer seismic data using pressure gradient approximationsLasse Amundsen, Tage Røsten, Johan O. A. Robertsson, and Ed Kragh14 January 2005 | GEOPHYSICS, Vol. 70, No. 1Data‐driven adaptive decomposition of multicomponent seabed recordingsRemco Muijs, Johan O. A. Robertsson, and Klaus Holliger27 September 2004 | GEOPHYSICS, Vol. 69, No. 5 SEG Technical Program Expanded Abstracts 2002ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Tage Røsten, Dirk‐Jan van Manen, Lasse Amundsen, and Johan Robertsson, (2002), "Optimal non‐recursive and recursive spatial filters for de‐multiple of OBS data," SEG Technical Program Expanded Abstracts : 1022-1025. https://doi.org/10.1190/1.1816817 Plain-Language Summary PDF DownloadLoading ...
Abstract 6539: Bioinformatics algorithm of mRNA-4157 identifies neoantigens with pre-existing TIL reactivities in colorectal tumors (2020)

Abstract Background: Personalized cancer vaccines (PCVs) encode mutation-derived epitopes (neoantigens) predicted from each tumor's unique set of somatic mutations, and can trigger the activation of neoantigen-specific CD4+ and/or CD8+ T cells to target cancer cells. The accurate prediction of immunogenic neoantigens from a tumor's mutanome, which may contain hundreds of somatic mutations, is crucial for designing an effective PCV. In this study, we evaluated the performance of the bioinformatics algorithm for mRNA-4157, an mRNA-based therapeutic PCV, in identifying neoantigens that are recognized by pre-existing tumor infiltrating lymphocytes (TILs) in a cohort of colorectal cancers shared by the National Cancer Institute (NCI) [1]. Methods: Whole exome and transcriptome sequencing data from 29 patients with microsatellite stable, mismatch repair (MMR)-proficient metastatic colorectal cancer were shared by NCI. All patients had received at least one previous systemic therapy, and neoantigen-reactive TIL populations had been identified from these patients by high-throughput immunologic screening [1]. The same bioinformatics algorithm as used for mRNA-4157 was run on the sequencing data, to generate a vaccine design for each patient that included up to 34 neoantigens. Results: Overall, 41% (26/64) of the neoantigens recognized by CD8+ or CD4+ TILs according to the NCI assay were included in the vaccines designed by the mRNA-4157 bioinformatics algorithm. For 61% (18/29) of the patients, at least one neoantigen with demonstrated CD8+ or CD4+ TIL reactivity was included in the vaccines designed. For 28% (8/29) of the patients, all neoantigens associated with demonstrated CD8+ or CD4+ TIL reactivities were included in the vaccines designed. Conclusion: The bioinformatics algorithm for mRNA-4157 is able to predict and select neoantigens with pre-existing TIL reactivities based on human ex vivo assays for vaccine designs with high accuracy. [1] Parkhurst MR, et al. Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers. Cancer Discov. 2019 Aug;9(8):1022-1035. Citation Format: Shan Zhong, Ben Breton, Wei Zheng, Iain McFadyen, Kristen Hopson, Joshua Frederick, Robert S. Meehan, Tal Zaks. Bioinformatics algorithm of mRNA-4157 identifies neoantigens with pre-existing TIL reactivities in colorectal tumors [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6539.
Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide (2017)

Usher syndrome type 1C (USH1C/harmonin) is associated with profound retinal, auditory and vestibular dysfunction. We have previously reported on an antisense oligonucleotide (ASO-29) that dramatically improves auditory function and balance behavior in mice homozygous for the harmonin mutation Ush1c c.216G > A following a single systemic administration. The findings were suggestive of improved vestibular function; however, no direct vestibular assessment was made. Here, we measured vestibular sensory evoked potentials (VsEPs) to directly assess vestibular function in Usher mice. We report that VsEPs are absent or abnormal in Usher mice, indicating profound loss of vestibular function. Strikingly, Usher mice receiving ASO-29 treatment have normal or elevated vestibular response thresholds when treated during a critical period between postnatal day 1 and 5, respectively. In contrast, treatment of mice with ASO-29 treatment at P15 was minimally effective at rescuing vestibular function. Interestingly, ASO-29 treatment at P1, P5 or P15 resulted in sufficient vestibular recovery to support normal balance behaviors, suggesting a therapeutic benefit to balance with ASO-29 treatment at P15 despite the profound vestibular functional deficits that persist with treatment at this later time. These findings provide the first direct evidence of an effective treatment of peripheral vestibular function in a mouse model of USH1C and reveal the potential for using antisense technology to treat vestibular dysfunction.
CO dissociation and CO+O reactions on a nanosized iron cluster (2009)

Catalysis over metal nanoparticles is essential for the growth of carbon nanotubes and all the properties of the resulting nanotube, such as diameter and chirality, are affected by the metal particle. Thus, it is very important to understand the carbon chemistry taking place on nanometer size metal particles. Here we present the first ab initio computational study of chemical reactions on a nanosized iron cluster. The clusters have reaction sites, such as edges and vertexes between the facets, Which have not been studied before. First principles electronic structure calculations, fully incorporating the effects of spin polarization and non-collinear magnetic moments, have been used to investigate CO disproportionation on an isolated Fe55 cluster. After CO dissociation, O atoms remain on the surface while C atoms move into the cluster, presumably as the initial step toward carbide formation. Here we show that the lowest CO dissociation barrier found on the cluster (0.77 eV) is lower than on most previously studied Fe surfaces. This dissociation occurs on a vertex between the facets. Several possible paths for CO2 formation were identified. The calculated lowest reaction barrier is 1.08 eV, which is comparable to the barrier of 0.65 eV obtained by experiment.
Draft Genome Sequence of the White-Rot Fungus Phanerochaete sordida YK-624 (2021)

Here, we report the draft genome sequence of the white-rot basidiomycete fungus Phanerochaete sordida YK-624 (ATCC 90872), which was isolated in Yakushima, Kagoshima, Japan. The genome of this strain was found to be 41.2 Mbp, with a G+C content of 58.7%, and to comprise 17,108 predicted protein-coding sequences.