gebhart/patrepeval huggingface dataset:
In search of a hole inversion layer in $\mathrm{Pd}/\mathrm{MoO}_{x}/\mathrm{Si}$ diodes through I- V characterization using dedicated ring-shaped test structures (2019)

Palladium (Pd) capped molybdenum-oxide (MoO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) thin films deposited bye-beam evaporation on p- and n-type silicon (Si) substrates were investigated employing dedicated ring-shaped test structures. The results show diode characteristics on n-type Si with a high rectification of ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> and a low leakage current of ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> A and an ohmic contact on p-type Si, as expected from the reported high workfunction of MoO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> . Reports in the literature that an inversion layer of holes should be present at the MoO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /n -Si interface were investigated via various DC electrical measurements on lateral test structures, but no indication of any significant inversion was found.
Frontispiece: Ultra‐Fast Supercritical Hydrothermal Synthesis of Tobermorite under Thermodynamically Metastable Conditions (2017)

Mineral SynthesisThe durability of buildings—from Roman to modern ones—is partly due to the mineral tobermorite which is used in cement. In their Communication on page 3162 ff., J. J. Gaitero, C. Aymonier et al. report how tobermorite can be synthesized in seconds.
Bone marrow recovery and subsequent chemotherapy following radiolabeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 in patients (pts) with metastatic castration-resistant prostate cancer (metCRPC) (2009)

e16004 Background: Reversible myelosuppression is the dose-limiting toxicity of radioimmunotherapy (RIT). Cases of marrow damage, including myelodysplasia and acute leukemia have been reported with the RIT most used to date (that targeting CD20 in Non- Hodgkin's lymphoma), though no statistically significant association exists. In addition, post-RIT chemotherapy (chemo) may theoretically be limited. We have treated metCRPC pts with anti-PSMA RIT since 2000 and analyzed post-therapy outcomes. Methods: Follow-up across 4 prospective phase I and II trials utilizing 177 Lu-J591 and 90 Y-J591 was performed. Quality of hematologic recovery from post-RIT myelosuppression was documented. Administration of pre- and post-RIT chemo was analyzed. Specific searches for subsequent myelodysplasia and/or leukemia were performed. Results: Median age of the 109 treated pts is 70 (range 47–88). Entry criteria for all trials included progressive metCRPC, PS &lt; 2, normal baseline neutrophil and platelet counts, and hemoglobin &gt; 10 g/dL. 80 received 177 Lu-J591 at cumulative doses ranging from 10–120 mCi/m 2 and 29 received 90 Y-J591 at cumulative doses of 5–40 mCi/m 2 . 43% received at least 1 line of pre-RIT chemo, 53% received at least 1 line of post-RIT chemo, and 20% have never received chemo to date. All pts with adequate performance status received chemo except per pt choice. Excluding re-treated pts, 98% and 87% of assessable pts had full recovery of neutrophils and platelets respectively. Of the remaining, all but 4 recovered to Gr 1 neutropenia and/or thrombocytopenia. The most common reason for lack of complete hematologic recovery was CRPC progression in bone marrow (16 pts with persistent or recurrent myelosuppression underwent bone marrow biopsy). No cases of post-RIT myelodysplasia and/or leukemia were discovered. Conclusions: Anti-PSMA radioimmunotherapy is well-tolerated with efficacy previously reported. While follow-up is ongoing, reports of irreversible bone marrow damage appear unfounded and all patients with intact performance status willing to undergo post-RIT chemotherapy are able to receive it. [Table: see text]
Heterogeneous vs homogeneous MPSoC approaches for a mobile LTE modem (2010)

Applications like 4G baseband modem require single-chip implementation to meet the integration and power consumption requirements. These applications demand a high computing performance with real-time constraints, low-power consumption and low cost. With the rapid evolution of telecom standards and the increasing demand for multi-standard products, the need for flexible baseband solutions is growing. The concept of Multi-Processor System-on-Chip (MPSoC) is well adapted to enable hardware reuse between products and between multiple wireless standards in the same device. Heterogeneous architectures are well known solutions but they have limited flexibility. Based on the experience of two heterogeneous Software Defined Radio (SDR) telecom chipsets, this paper presents the homoGENEous Processor arraY (GENEPY) platform for 4G applications. This platform is built with Smart ModEm Processors (SMEP) interconnected with a Network-on-Chip. The SMEP, implemented in 65nm low-power CMOS, can perform 3.2 GMAC/s with 77 GBits/s internal bandwidth at 400MHz. Two implementations of homogeneous GENEPY are compared to a heterogeneous platform in terms of silicon area, performance and power consumption. Results show that a homogeneous approach can be more efficient and flexible than a heterogeneous approach in the context of 4G Mobile Terminals.
High-performance thin-layer chromatography/fast atom bombardment (tandem) mass spectrometry ofPseudomonas rhamnolipids (1994)

Several rhamnolipid preparations from Pseudomonas strains were studied by thin-layer chromatography/fast atom bombardment (TLC/FAB) mass spectrometry and TLC/FAB tandem mass spectrometry (MS/MS). The preparations were separated with normal-phase (Silica 60) and reversed-phase (RP-8) chromatography. Silica 60 plates appeared to be very useful in the separation of rhamnolipids according to the number of monosaccharide residues present. Spectra which show characteristic fragment ions could be obtained from components of mixtures with a total sample size of less than 200 ng. Chromatography on RP-8 plates gave a good separation of the rhamnolipids based on the length of the fatty acid alkyl chain. MS/MS of the sodium cationized molecules gave information about the sequence of the building blocks. Particularly, heterogeneity in beta-hydroxy fatty acid composition was determined for the principal as well as minor components present in natural rhamnolipid mixtures.
59. Multiplex Gene Activation by CRISPR/Cas9-Based Transcription Factors for the Direct Conversion of Fibroblasts to a Neuronal Phenotype (2015)

The reprogramming of cell lineage between mature somatic cell types has a significant potential to advance disease modeling, drug discovery, and gene and cell therapies for regenerative medicine. Several groups have established methods to reprogram cell phenotype through the ectopic delivery of cDNAs encoding master regulatory transcription factors. These factors can target epigenetically silenced genes and activate transcriptional networks specific to other cell lineages. The recent advances made in engineering the CRISPR/Cas9 system as a programmable transcriptional regulator provide an opportunity to study alternate methods to achieve cell reprogramming. The dCas9-based transcription factors (dCas9-TFs) can attain multiplex activation and repression of endogenous genes. It's simplicity of use enables a standardized method of regulating endogenous transcriptional networks in any cell type of interest. The ability of dCas9-TFs to target virtually any region of the genome within the native chromatin context provides an opportunity to study how non-coding regulatory elements and epigenetic signatures influence reprogramming outcomes. Here we demonstrate the capacity of dCas9-TFs to drive the direct conversion of murine embryonic fibroblasts (MEFs) to cells of a neuronal phenotype. We utilized a dCas9-TF with both N-terminal and C-terminal VP64 transactivation domains and demonstrated a 10-fold improvement in activation of target genes compared to dCas9-TFs with only a single VP64. Using this dCas9-TF variant, we demonstrated the multiplex activation of BRN2, ASCL1, and MYT1L (BAM factors) in MEFs. These three factors have been shown to generate functional neurons when expressed ectopically in MEFs. When compared to overexpression of the transgenes, dCas9-TFs induced significantly less mRNA and protein expression of the BAM factors, as determined by qRT-PCR and immunofluorescence staining. However, by day 14 in culture following the delivery of dCas9-TFs targeting the endogenous BAM factors, we identified cells positive for the pan-neuronal markers TUJ1 and MAP2 that exhibited complex neuronal morphologies. Furthermore, we found that dCas9-TFs were able to generate 23% more TUJ1/MAP2-co-positive cells than that achieved through the ectopic delivery of the BAM factors. Electrophysiological recordings of these cells identified single, action potential-like responses to step-depolarization by current clamp in the whole cell configuration. The cells also displayed calcium transients in response to KCl-induced depolarization, measured by monitoring fluorescence intensity of a GCaMP reporter. Ongoing work is focused on improving the functional maturity of the cells and addressing the kinetics of gene activation and epigenetic reprogramming at the target loci. We hypothesize that the targeted activation at the endogenous loci may more deterministically reprogram the chromatin to marks of active transcription that stabilize gene expression.
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy (2015)

High glucose levels in the peripheral nervous system (PNS) have been implicated in the pathogenesis of diabetic neuropathy (DN). However, our understanding of the molecular mechanisms that cause the marked distal pathology is incomplete. We performed a comprehensive, system-wide analysis of the PNS of a rodent model of DN. We integrated proteomics and metabolomics from the sciatic nerve (SN), the lumbar 4/5 dorsal root ganglia (DRG), and the trigeminal ganglia (TG) of streptozotocin-diabetic and healthy control rats. Even though all tissues showed a dramatic increase in glucose and polyol pathway intermediates in diabetes, a striking upregulation of mitochondrial oxidative phosphorylation and perturbation of lipid metabolism was found in the distal SN that was not present in the corresponding cell bodies of the DRG or the cranial TG. This finding suggests that the most severe molecular consequences of diabetes in the nervous system present in the SN, the region most affected by neuropathy. Such spatial metabolic dysfunction suggests a failure of energy homeostasis and/or oxidative stress, specifically in the distal axon/Schwann cell-rich SN. These data provide a detailed molecular description of the distinct compartmental effects of diabetes on the PNS that could underlie the distal-proximal distribution of pathology.
Salvage cryosurgery of the prostate after radiation failure. (2004)

Radiation therapy is one option for patients with localized prostate cancer. Despite advances in delivering radiation to the prostate gland with therapies such as brachytherapy and/or external beam radiation therapy, urologists will be faced with managing patients with rising prostate-specific antigen values and with positive biopsy results secondary to radiation-recurrent prostate cancer. If the cancer is detected early, salvage therapy can be initiated. Since salvage prostatectomy is associated with significant morbidity, patients are often left with the option of either watchful waiting or temporary palliation with hormone deprivation therapy, with its attendant toxicity. The introduction of third-generation cryotechnology using 17-gauge CryoNeedlestrade mark (Oncura, Inc., Plymouth Meeting, PA) and the recent modifications in the technique of salvage cryosurgery have enabled cryosurgeons to eradicate these tumors safely and with significantly decreased morbidity. Selection and management of patients, as well as the contemporary results of salvage cryosurgery, are discussed in this article.
Examination of Phonon Dissipation in 33 GHz Overmoded Bulk Acoustic Resonators (2022)

In this work we examine quality factor ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$Q$</tex> ) in an overmoded bulk acoustic resonator (OBAR) operating at 33 GHz through modeling and measurement of fabricated devices to isolate loss mechanisms. Intrinsic and extrinsic loss mechanisms are modeled using a combination of material analytical models and energy distribution determined by finite element analysis. Fabricated devices with varying area and aspect ratio are then measured. Finally, devices are characterized over temperature from 295 K to 12.5 K. By comparing geometric dependencies between models and measurements we conclude anchor and ohmic losses are not significant in these devices. However, much lower thermal dependence in measured devices indicate intrinsic loss models do not fully describe losses in these devices. Further investigation in intrinsic damping in materials at microwave frequencies are needed.
P112 <break /> Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis (2016)

Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality in disorders that include IPF. The αvβ6 integrin has been identified as playing a key role in the activation of TGFβ that is hypothesized to be pivotal in …
Ternary Ag/MgO‐SiO2 Catalysts for the Conversion of Ethanol into Butadiene (2014)

Ternary Ag/Magnesia-silica catalysts were tested in the direct synthesis of 1,3-butadiene from ethanol. The influence of the silver content and the type of silica source on catalytic performance has been studied. Prepared catalysts were characterized by (29) Si NMR, N2 sorption, small-angle X-ray scattering measurements, XRD, environmental scanning electron microscopy with energy dispersive X-ray analysis (ESEM/EDX), FTIR spectroscopy of adsorbed pyridine and CO2 , temperature-programmed desorption of CO2 and UV/Vis diffuse reflectance spectroscopy. Based on these characterization results, the catalytic performance of the catalysts in the 1,3-butadiene formation process was interpreted and a tentative model explaining the role of the different catalytically active sites was elaborated. The balance of the active sites is crucial to obtain an active and selective catalyst to form 1,3-butadiene from ethanol. The optimal silver loading is 1-2 wt% on a MgO-silica support with a molar Mg/Si ratio of 2. The silver species and basic sites (Mg−O pairs and basic OH groups) are of prime importance in the 1,3-butadiene production, catalyzing mainly the ethanol dehydrogenation and the aldol condensation, respectively.
Public key cryptanalysis using algebraic and lattice methods (2002)

We study the security of public key cryptosystems. In particular we study the RSA public key cryptosystem and several variants. We obtain our results using tools from the theory of integer lattices. 
We begin with an introduction to the theory of integer lattices and describe the main results to be used throughout the rest of the work. We then review the concept of a public key cryptosystem and in particular the RSA public key cryptosystem. Next we introduce a novel algorithm for the factorization of class of integers closely related to those used by RSA and other public key cryptosystems in the literature, showing that a new class of integers can be efficiently factored. We go on to introduce new attacks on the RSA public key cryptosystem which use partial knowledge of a user's secret key, showing that leaking one quarter of the bits of the secret key is sufficient to compromise RSA. Next we describe new attacks on the RSA public key cryptosystem when a short secret exponent is used. Lastly, we describe the three Sun-Yang-Laih key generation schemes for RSA, and introduce attacks to break two of these schemes.
Naturally-Transitioning Rate-to-Force Control in Free and Constrained Motion (1999)

The Naturally-Transitioning Rate-to-Force Controller (NTRFC) is presented for teleoperation of manipulators. Our goal is to provide a single controller which handles free motion, constrained motion, and the transition in-between without any artificial changes. In free motion the displacement of the master device (via the human operator’s hand) is proportional to the commanded Cartesian rate of the manipulator. In contact, the displacement of the human operator’s hand is proportional to the wrench (force/moment) exerted on the environment by the manipulator. The transition between free rate motion and applied-wrench contact with the environment requires no changes in control mode or gains and hence is termed natural. Furthermore, in contact, if the master enables force reflection, the wrench of the human operator’s hand exerted on the master is proportional to the wrench exerted on the environment by the manipulator. This article demonstrates the NTRFC concept via a simple 1-dof model and then discusses experimental implementation and results from a Merlin manipulator teleoperated via the force-reflecting PHANToM interface.
Experimental Demonstration of a Mode-Competing Multiline Resonant Laser (2014)

A multiline guided-mode resonance (GMR) filter is applied as a reflector to implement an external cavity laser. We design the resonant element using rigorous numerical methods and fashion an experimental prototype by thin-film deposition, patterning, and etching. A ~100-nm TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> grating layer on a ~170-μm-thick glass slab supports thousands of resonant modes. We detect ~10 narrow resonance peaks within a ~10-nm wavelength range centered at the 840-nm wavelength. We apply this multiline GMR device to a gain chip and obtain several simultaneous resonant laser lines that compete for the gain. Precise tuning enables a stable laser line that can be selected from the multiple available resonant lines.
Are interferometric encoders a reasonable alternative in servo drive applications? (2008)

In 2005 and 2006 there have been publications explaining the technical requirements of encoders to be used in electrical drives with digital control. The main statement of these papers have been that neither high resolution resolvers nor high resolution optical encoders really do provide features as good as of analogue tacho generators. The performance of servo drives with digital control, however, has improved in comparison to former drives with analogue control. Nevertheless the speed detection performance of optical encoders still cannot cope with high precision tacho generators - they still are the technical bottle neck for further improvements in digital drive control. This paper reports on some development in the field of interferometric encoders, which, provide a significant higher resolution than optical encoders. Technical results obtained by some initiative research indicate, that interferometric encoders have a good potential and should investigated more further on.
[Viewing 3D stereoscopic images in children and adults with and without strabismus: multicenter study in Japan]. (2013)

Since many patients with strabismus and/or amblyopia found some difficulty in stereoscopic viewing, precise examinations for stereopsis and convergence are needed to assess individual aptitude for 3D viewing.
Palm-Area Sensitivity To Vibrotactile Stimuli Above 1~{Khz} (2012)

The upper limit of frequency sensitivity for vibrotactile stimulation of the fingers and hand is commonly accepted as 1 kHz. However, during the course of our research to develop a full-hand vibrotactile musical communication device for the hearing-impaired, we repeatedly found evidence suggesting sensitivity to higher frequencies. Most of the studies on which vibrotactile sensitivity are based have been conducted using sine tones delivered by point-contact actuators. The current study was designed to investigate vibrotactile sensitivity using complex signals and full, open-hand contact with a flat vibrating surface representing more natural environmental conditions. Sensitivity to frequencies considerably higher than previously reported was demonstrated for all the signal types tested. Furthermore, complex signals seem to be more easily detected than sine tones, especially at low frequencies. Our findings are applicable to a general understanding of sensory physiology, and to the development of new vibrotactile display devices for music and other applications.
The Induction of Meningeal Inflammation and Blood-Brain Barrier Permeability by Haemophilus influenzae Type b Peptidoglycan (1994)

Journal Article The Induction of Meningeal Inflammation and Blood-Brain Barrier Permeability by Haemophilus influenzae Type b Peptidoglycan Get access John J. Roord, John J. Roord Reprints or correspondence: Dr. John J. Roord, University Children's Hospital, Het Wilhelmina Kinderziekenhuis, P.O. Box 18009, 3501 CA Utrecht, Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Apicella, Michael Apicella Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Michael ScheId W. Michael ScheId Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 170, Issue 1, July 1994, Pages 254–256, https://doi.org/10.1093/infdis/170.1.254-a Published: 01 July 1994
Dynamic Electromechanical Model and Position Controller Design of a New High-Precision Self-Bearing Linear Actuator (2020)

Direct drive tubular linear actuators (TLAs) may be used in various applications that require fast movements and high-precision positioning, e.g., pick-and-place robots. This article presents the analysis, dynamic electromechanical model derivation, controller design, and system operation of a TLA with integrated magnetic bearings (MBs). Furthermore, the actuator operation is verified with extensive measurements on the prototype, which include axial position step response, standard deviation of the steady-state positions and mover tilting control. Compared with any conventional TLA, which may perform only linear motion, the mover tilting control is possible due to integrated MBs. This gives the new actuator a great advantage in high-precision positioning systems, since any thermal expansions of the parallel kinematics may be compensated.