gebhart/patrepeval huggingface dataset:
LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers (2016)

Abstract LIM kinases (LIMK) are emerging targets for cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics. When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are stabilized. Owing to their stabilizing effect on microtubules, LIMK inhibitors may provide a therapeutic strategy to treat taxane-resistant cancers. In this study, we investigated the effect of LIMK inhibition on breast tumor development and on paclitaxel-resistant tumors, using a novel selective LIMK inhibitor termed Pyr1. Treatment of breast cancer cells, including paclitaxel-resistant cells, blocked their invasion and proliferation in vitro and their growth in vivo in tumor xenograft assays. The tumor-invasive properties of Pyr1 were investigated in vivo by intravital microscopy of tumor xenografts. A striking change of cell morphology was observed with a rounded phenotype arising in a subpopulation of cells, while other cells remained elongated. Notably, although Pyr1 decreased the motility of elongated cells, it increased the motility of rounded cells in the tumor. Pyr1 administration prevented the growth of metastasis but not their spread. Overall, our results provided a preclinical proof of concept concerning how a small-molecule inhibitor of LIMK may offer a strategy to treat taxane-resistant breast tumors and metastases. Cancer Res; 76(12); 3541–52. ©2016 AACR.
3D Front crawl swimming kinematics analysis: markerless vs marker based approach (2012)

Research on motion analysis of swimmers is commonly based on video recordings of the subject's motion, which are analyzed by manual digitization of feature points by an operator. This procedure has two main drawbacks: it is time-consuming, and it is affected by low repeatability. In order to overcome these drawbacks, the authors recently developed a video-based, markerless system for the analysis of arm movements during front crawl swimming (Ceseracciu et al. 2011). The aim of the present contribution is to evaluate accuracy of the proposed technique in estimating three-dimensional (3D) joint kinematics either in term of joints coordinates or angles. 3D coordinates of shoulder, elbow and wrist joints centers together with 3D elbow joints’ angles of an elite sprint swimmer, while performing front crawl swimming, were determined. Both markerless technique and the Calibrated Anatomical Systems Technique (CAST) (Cappozzo et al. 1995) were adopted. An automatic tracking technique was developed and employed in order to track the features necessary to apply the CAST technique. Root mean square distance (RMSD) values between trajectories and joint angles estimated with the two techniques were determined. Results showed good accuracy, and reliability (RMSD
Multi-Gateway Cooperation in Multibeam Satellite Systems (2011)

Multibeam systems with hundreds of beams have been recently deployed in order to provide higher capacities by employing fractional frequency reuse. Furthermore, employing full frequency reuse and precoding over multiple beams has shown great throughput potential in literature. However, feeding all this data from a single gateway is not feasible based on the current frequency allocations. In this context, we investigate a range of scenarios involving beam clusters where each cluster is managed by a single gateway. More specifically, the following cases are considered for handling intercluster interference: a) conventional frequency colouring, b) joint processing within cluster, c) partial CSI sharing among clusters, d) partial CSI and data sharing among clusters. CSI sharing does not provide considerable performance gains with respect to b) but combined with data sharing offers roughly a 40% improvement over a) and a 15% over b).
392 A Morphological Study of Non-Stenotic Carotid Atheromas Causing Recurrent Strokes: Chronicle of Disruption and Stabilization (2023)

INTRODUCTION: Symptomatic non-stenotic carotid (SyNC) artery disease is a recognized etiology of ischemic strokes with a putative thromboembolic mechanism. To date, the structural phenotypes expressed at the lumen/wall interface of these lesions are not completely understood resulting in misdiagnosis and hindering the development of targeted therapies. METHODS: After IRB approval, en block endarterectomy specimen were obtained from patients with recurrent strokes from SyNC (n=9). Additionally, segments of superficial temporal artery (STA) of patients undergoing cerebral artery bypass surgeries were obtained as controls (n=3). The endovascular surfaces of the samples were imaged with laser microangioscopy and scanning electron microscopy (SEM). Images were benchmarked with histological sections and immunohistochemistry (IHC). RESULTS: Normal endothelial surfaces in STA were light pink, smooth and homogenous by angioscopy with typical cobblestone endothelial pattern. Features recognized as those associated with plaque disruption and thrombosis were de-endothelialization, inflammatory infiltrates within and under the endothelium, delamination (flaps oriented to the flow) with superficial intimal hemorrhages, plaque erosion and disruption of the fibrous cap with fissuring, ulceration, excavation and plaque hemorrhage. Additionally, cellular and acellular structures actively involved in plaque stabilization, seen on SEM and confirmed with histology and IHC, were also identified including activated platelets, fibrin band, bridges and webs, neutrophil extracellular traps and endothelial progenitor cells. CONCLUSIONS: This ultrastructural study of the vascular surface of SyNC specimens reveals concurrent phenotypes of flow-dependent disruption and stabilization that could become new imaging biomarkers and enable the development of targeted therapies.
Opposed-Piston 2-Stroke Multi-Cylinder Engine Dynamometer Demonstration (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;With mounting pressure on Indian manufacturers to meet future fuel economy and emissions mandates-including the recently passed Corporate Average Fuel Consumption (CAFC) standards for light-duty vehicles-many are evaluating new technologies. However, to provide an economically sustainable solution, these technologies must increase efficiency without increasing cost.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;One promising solution to meet both current, and future, standards is the opposed-piston engine. Widely used in the early 20&lt;sup&gt;th&lt;/sup&gt; century for on-road applications, use of the opposed-piston engine waseventually discontinued due to challenges with emissions and oil control. But advancements in computer-aided engineering tools, combined with state-of-the-art engineering practices, has enabled Achates Power to develop a modern opposed-piston diesel engine architecture that is clean, significantly more fuel efficient and less expensive to manufacture than today's four-stroke engines.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In addition to a short explanation of the opposed-piston engine and its inherent efficiency benefits, this technical paper will provide detailed performance and emissions results of a multi-cylinder Achates Power opposed-piston engine configured to meet commercial truck requirements. These results, which will be presented for the first time in India, demonstrate the engine's ability to: &lt;ul class="list disc"&gt;&lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Substantially improve fuel economy over the best diesels in the same class&lt;/div&gt;&lt;/li&gt;&lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Comply with U.S. 2010/Euro 6 emissions standards&lt;/div&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper also provides a detailed overview of the opposed-piston multi-cylinder test engine's indicated thermal efficiency, friction and pumping losses.&lt;/div&gt;&lt;/div&gt;
Highly Efficient Representation Of Reconfigurable Code Based On A Radio Virtual Machine: Optimization To Any Target Platform (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
Technical Evaluation of a New Immunoradiometric and a New Immunoluminometric Assay for Thyroglobulin (2002)

The new assays have improved precision for Tg <1 microg/L, and even low measured Tg concentrations respond physiologically to thyroxine withdrawal. The assays are free of a high-dose hook effect up to a Tg concentration of at least 38 000 microg/L and may further reduce Tg antibody interference.
Measurement of the W-boson helicity in top-quark decays from $ \mathrm{t}\overline{\mathrm{t}} $ production in lepton+jets events in pp collisions at $ \sqrt{s}=7 $ TeV (2013)

A bstract The W-boson helicity fractions in top-quark decays are measured with $ \mathrm{t}\overline{\mathrm{t}} $ events in the lepton+jets final state, using proton-proton collisions at a centre-of-mass energy of 7 TeV, collected in 2011 with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 5.0 fb −1 . The measured fractions of longitudinal, left-, and right-handed helicity are F 0 = 0 . 682 ± 0 . 030 (stat.) ± 0 . 033 (syst.), F L = 0 . 310 ± 0 . 022 (stat.) ± 0 . 022 (syst.), and F R = 0 . 008 ± 0 . 012 (stat.) ± 0 . 014 (syst.), consistent with the standard model predictions. The measured fractions are used to probe the existence of anomalous Wtb couplings. Exclusion limits on the real components of the anomalous couplings g L , g R are also derived.
About the effects of combining Latent Semantic Analysis with natural language processing techniques for free-text assessment (2005)

Este artículo presenta la combinación de Análisis Semántico Latente (LSA) con otras técnicas de procesamiento del lenguaje natural (lematización, eliminación de palabras funcionales y desambiguación de sentidos) para mejorar la evaluación automática de respuestas en texto libre. El sistema de evaluación de respuestas en texto libre llamado Atenea (Alfonseca &amp; Pérez, 2004) ha servido de marco experimental para probar el esquema combinacional. Atenea es un sistema capaz de realizar preguntas, escogidas aleatoriamente o bien conforme al perfil del estudiante, y asignarles una calificación numérica. Los resultados de los experimentos demuestran que para todos los conjuntos de datos en los que las técnicas de PLN se han combinado con LSA la correlación de Pearson entre las notas dadas por Atenea y las notas dadas por los profesores para el mismo conjunto de preguntas mejora. La causa puede encontrarse en la complementariedad entre LSA, que trabaja a un nivel semántico superficial, y el resto de las técnicas NLP usadas en Atenea, que están más centradas en los niveles léxico y sintáctico.
Correction to: Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma (2019)

Following publication of the original article [1], the author reported that the current funding section “Kidney Cancer Association Young Investigator Grant provided funding for this project” should be replaced with “Kidney Cancer Association Young Investigator Grant and Bucks County Board provided funding for this project.”
An inertial and environmental wireless platform with advanced energy harvesting capabilities (2015)

This work presents neMEMSi-TEG, an ultra-low power MEMS based inertial and magnetic platform with embedded processing and wireless communication capabilities. The platform embeds an advanced energy management IC that allows an extremely high efficiency energy harvesting suitable for low-power and miniaturized Thermoelectric Generators. This paper aims to provide a description of the architecture of the system, the embedded orientation estimation algorithm and the performance in terms of power consumption and orientation accuracy.
Aggresomeâ€“Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 Gene (2014)

The four-and-half LIM domain protein 1 (FHL1) is highly expressed in skeletal and cardiac muscle. Mutations of the FHL1 gene have been associated with diverse chronic myopathies including reducing body myopathy, rigid spine syndrome (RSS), and Emery-Dreifuss muscular dystrophy. We investigated a family with a mutation (p.C150R) in the second LIM domain of FHL1. In this family, a brother and a sister were affected by RSS, and their mother had mild lower limbs weakness. The 34-year-old female had an early and progressive rigidity of the cervical spine and severe respiratory insufficiency. Muscle mass evaluated by DXA was markedly reduced, while fat mass was increased to 40%. CT scan showed an almost complete substitution of muscle by fibro-adipose tissue. Muscle biopsy showed accumulation of FHL1 throughout the cytoplasm and around myonuclei into multiprotein aggregates with aggresome/autophagy features as indicated by ubiquitin, p62, and LC3 labeling. DNA deposits, not associated with nuclear lamina components and histones, were also detected in the aggregates, suggesting nuclear degradation. Ultrastructural analysis showed the presence of dysmorphic nuclei, accumulation of tubulofilamentous and granular material, and perinuclear accumulation of autophagic vacuoles. These data point to involvement of the aggresome-autophagy pathway in the pathophysiological mechanism underlying the muscle pathology of FHL1 C150R mutation.
InGaAsP thin-film microdisk resonators fabricated by polymer wafer bonding for wavelength add-drop filters (2000)

10-μm-diameter InGaAsP thin-film microdisk resonators have been fabricated using polymer-wafer bonding with benzocylobutene. This wafer bonding process is to provide strong two-dimensional mode confinement in the waveguide and reduce the optical propagation loss. The measured resonance linewidth at wavelength 1.55 μm is about 0.22 nm with a free-spectral range of 20 nm. The narrow linewidth and large free-spectral range make these devices conducive to the applications in dense wavelength division multiplexed systems.
Competition between organic superconductivity and a displacive structural modulation in the molecular stacks in bis(ethylenedithio) tetrathiafulvalene perrhenate, (BEDT-TTF)2ReO4 (1986)

The pressure-induced organic superconductor bis(ethylenedithio) tetrathiafulvalene perrhenate, (BEDT-TTF${)}_{2}$${\mathrm{ReO}}_{4}$, is shown to undergo a first-order structural phase transition with an associated metal-to-insulator transition near T=77 K at ambient pressure. Superstructure reflections with reduced wave vectors q=((1/2),0,(1/2)) are found using single-crystal x-ray diffraction. Evidence is presented that these are not associated with a change of the anion ordering but result from a displacive structural modulation, which most probabably involves both the ${\mathrm{ReO}}_{4}$${\mathrm{}}^{\mathrm{\ensuremath{-}}}$ anion and BEDT-TTF molecular sublattices.
Applications of the Jefferson Lab free-electron laser for photobiology (2000)

A versatile free electron laser (FEL) user facility has recently come on line at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) providing high average (kilowatt-level) power laser light in the infrared. A planned upgrade of the FEL in this facility will extend the wavelength range through the visible to the deep UV and provide the photobiology community with a unique light source for a variety of studies. Planned and potential applications of this FEL include: IR studies of energy flow in biomolecules, IR and visible imaging of biomedical systems, IR and visible studies of photodynamic effects and UV and near visible studies of DNA photodamage.
2.3 SOLI: A Tiny Device for a New Human Machine Interface (2021)

With the introduction of the Internet of Things (IoT), there is an increasing focus on human-to-machine interaction. Nowadays, sensors make system and robots to see, hear, feel, and intuitively “understand” their surroundings. 60GHz radar [1] provides a very attractive solution for the sensing of human motion, enabling specific use cases such as: smart presence, hand gesture, and vital signs monitoring. Those can enhance the user experience in wearables, mobile devices, TVs, smart homes, automotive infotainment systems and AR-VR applications. The high bandwidth allocated in the 60GHz band (from 57 to 64GHz) enables very high range resolution sensing (≈2cm), which, when complemented with micro-Doppler and time domain analysis [2], offers a powerful tool for discriminating complex hand movements with millimeter accuracy. The solution presented in this paper represents the a tiny radar system integrated into a smartphone, the Google Pixel 4. The simplified signal flow pipeline, from the radar sensor up to the signal transformation and classification, is presented in Fig. 2.3.1 [3]. The radar sensor is designed primarily taking into account all the integration boundaries, which includes in primis power consumption and package size (including antenna). Specifically, the power consumption requirement translates to a very stringent requirement for the maximum number of chirps the sensor could run per frame, impacting the process gain, and so the maximum detection range.
Supp Figure Legends from Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia (2023)

&lt;p&gt;Supp Fig 1-3 Legends&lt;/p&gt;
Thermometry of Filamentary RRAM Devices (2015)

Since thermal effects play a major role in filamentary RRAM devices, we compare the two localized thermometry methods developed for such devices. One method is based on short-pulsed measurements and the other on the measurement of minority-carrier injection from the filament into a semiconductor electrode by thermionic emission. We carried out and compared the measurements on the same functional oxide layer. Both methods indicate that the filament temperature is at least ~550 K during device operation. Furthermore, comparison between the measured thermal resistance and the thermal simulations of both techniques shows that under the conditions of low forming current compliance (~10 μA), the filament dimensions are below ~5 nm. We show that the thermionic emission method is useful for high-resistance (>100 kQ) devices operating at low-power conditions (<;10 μW), whereas the pulsed thermometry is more suitable for lower resistance devices (<;500 kQ) operated above 1 μW. The average thermal resistance measured by the pulse technique decreases with applied power. Our simulations indicate that the expansion of the heated zone surrounding the filament can explain the observed reduction in thermal resistance with applied power. The underlying physics of the two methods is discussed.
[Prevention and early detection of colorectal cancer in average risk population--summary of a meeting and the Israeli gastroenterology policy]. (2003)

Current data on fecal occult blood test, sigmoidoscopy, and colonoscopy was presented, including the reduction of cancer incidence and mortality, safety and cost-effectiveness of each modality. Worldwide and Israeli results on colonoscopy in average-risk persons age 50-75, demonstrated a considerable prevalence of neoplasia, a low morbidity rate, no mortality and a high cost-effectiveness. Based on these results and the literature evidence of up to 90% reduction of CRC mortality following colonoscopy, CRC justifies all the criteria for organizing a prevention program by the health authorities for average-risk population age 50-75. Screening colonoscopy for CRC prevention should be included in this program.
Extracellular microRNAs and oxidative stress in liver injury: a systematic mini review (2018)

Recent evidence has suggested that extracellular microRNAs have crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury. Endothelial cell-specific miR-126-3p was the most studied extracellular miRNA associated with oxidative stress. In addition, we highlight some reports that describe the mechanisms of how oxidative stress affects extracellular microRNA profiles in liver injury. In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera. The release of miR-122-5p, miR-192-5p, and miR-1224-5p from hepatocytes may be attributed to oxidative stress. miR-223-3p could be released from neutrophils and suppress oxidative stress in the liver. Elucidation of the mechanisms of the interaction between extracellular microRNAs and oxidative stress would improve our pathophysiological understanding as well as future medical practice.
TheS-Thioester Enolate/Imine Condensation: A Shortcut to β-Lactams (2000)

The condensation between imines and S-thioester metal enolates provides a mild, efficient, and straightforward route to the preparation of β-lactams. The synthetic applications and the stereochemical aspects of this reaction are discussed.
The N-acetylglucosamine sensor NagC regulates LEE gene expression in EHEC (2017)

National audience
Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation. (1987)

The role of the T-cell-derived lymphokine B-cell stimulatory factor 1 (BSF-1) in the early activation, proliferation, and antibody-forming cell (AFC) clone formation of single fluorescein-specific B lymphocytes isolated from normal mouse spleens by hapten-gelatin adherence has been studied in vitro. BSF-1 acting alone induced early B-cell activation, as assessed by a significant increase in cell diameter of single B cells cultured for 24 hr. A small but significant number of these B cells formed proliferating clones, some of which secreted antibody. When acting with the specific antigen fluorescein-polymerized flagellin, BSF-1 augmented early cell enlargement and markedly enhanced proliferation, but it did not increase the frequency of AFC clones stimulated by fluorescein-polymerized flagellin alone. The further addition of recombinant murine interleukin 1 (IL-1) marginally enhanced proliferation caused by antigen plus BSF-1. No synergy was observed between BSF-1 and IL-1 for antibody formation. In the presence of fibroblast filler cells, BSF-1 substantially inhibited AFC clone development achieved by antigen plus IL-1. BSF-1 was also found to be inhibitory to AFC clone development stimulated by specific antigen acting with either recombinant human interleukin 2 (IL-2) or with IL-2 plus IL-1, both in the presence or absence of filler cells. The results suggest that BSF-1 plays a complex role in the regulation of the B-cell activation pathway by enhancing early activation and antigen-specific proliferation as well as inhibiting the effects of other B-cell factors on antibody formation. BSF-1 is the only cytokine so far tested in the single B-cell system that acts with antigen to promote proliferation without concomitant antibody production.
Cascaded reconfigurable optical add/drop multiplexer (ROADM) in metro add/drop network applications (2006)

We experimentally studied the cascadability of a 200 GHz channel spaced ROADM for Metro network applications using a re-circulating loop. After seven cascaded nodes and 1100-km transmission, a 2.5 dB sensitivity penalty was observed.