gebhart/patrepeval huggingface dataset:
Abstract P3-05-13: Estrogen-independent growth of ESR1-mutant breast cancer cells requires CDK4/6 (2016)

Abstract A recent breakthrough in cancer treatment has been the development of highly specific cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. CDK4/6 inhibitors, such as palbociclib, prevent cell cycle progression from growth phase (G1) to the DNA synthesis (S) phase of the cell cycle. Palbociclib, however, is only approved for first-line treatment of patients with estrogen receptor positive (ER+) breast cancer in combination with an aromatase inhibitor, letrozole. Approximately 20% of metastatic breast cancer patients, harbor an activating mutation in the ligand-binding domain (LBD) of the estrogen receptor gene, ESR1, which confers resistance to estrogen deprivation. It is unclear whether tumors harboring these endocrine treatment-associated mutations will also respond to CDK4/6 inhibition. We have found that estrogen-independent growth of ESR1 -mutant breast cancer cells requires CDK4/6. Thus, ESR1-mutant breast cancer cells are sensitive to CDK4/6 inhibition. Mechanistically, ERS1 LBD-mutant cells upregulate key mediators of the G1-S cell cycle transition. Furthermore, the sensitivity of ESR1-mutant breast cancer cells to CDK4/6 inhibition requires RB1. While cells expressing RB1 respond to CDK4/6 inhibition, knockout of RB1 via CRISPRs enables ESR1-mutant breast cancer cells to resist combined estrogen depletion and CDK4/6 inhibition. Our studies suggest that tumors harboring ESR1 LBD mutations and an intact RB1 will respond to combined CDK4/6 inhibition and estrogen deprivation. Citation Format: Luo F, Le X, Jeselsohn R, Brown M, Garraway L. Estrogen-independent growth of ESR1-mutant breast cancer cells requires CDK4/6. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-05-13.
Processing of zero offset vertical seismic profile data (1982)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1982Processing of zero offset vertical seismic profile dataAuthors: Paul TarielDominique MichonCharles NavilleGildas OmnesPaul TarielCGG, Dominique MichonCGG, Charles NavilleCGG, and Gildas OmnesCGGhttps://doi.org/10.1190/1.1826863 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826863FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1982ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1982 Pages: 520 publication data© 1982 Copyright © 1982 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION Paul Tariel, Dominique Michon, Charles Naville, and Gildas Omnes, (1982), "Processing of zero offset vertical seismic profile data," SEG Technical Program Expanded Abstracts : 152-154. https://doi.org/10.1190/1.1826863 Plain-Language Summary PDF DownloadLoading ...
ChemInform Abstract: Total Synthesis of Plagiochins C (VII), and D (VI), Macrocyclic Bis(bibenzyl) Constituents of Plagiochila acantophylla. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Clinical Relevance of Fcγ Receptor Polymorphisms (1997)

Human IgG receptors are very heterogeneous and we currently distinguish three Fc gamma receptor classes specifying at least 12 receptor isoforms. On top of this complexity, Fc gamma R are further found to differ between different individuals. Polymorphisms have been identified for all three Fc gamma R classes. The best-studied ones represent allelic variation of Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16). The Fc gamma RIIa polymorphism is now considered to be a heritable risk factor for autoimmune and infectious diseases, and support for a relevant role of the IIIb polymorphism has also been obtained. A detailed analysis of the exact contribution of each of these Fc gamma R polymorphisms in relation to previously implicated risk factors should unravel the pathophysiological importance of Fc gamma R polymorphisms in the near future.
Stimulation of apolipoprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells. (1991)

Although steroid hormones are known to play a predominant role in the regulation of cell growth in hormone-sensitive cancers, their mechanisms of action, especially their interaction with growth factors and/or growth inhibitors, is poorly understood. We have recently observed that the effects of androgens and estrogens on the expression of the major protein found in human breast gross cystic disease fluid, protein-24, are opposite to their respective action on cell proliferation in human breast cancer cell lines. Somewhat surprisingly, the recent elucidation of the amino acid sequence of this progesterone binding protein reveals that this tumor marker is apolipoprotein D (apo D), a member of a superfamily of lipophilic ligand carrier proteins. The present study was designed to determine whether apo D is secreted by human prostate cancer cells and could thus be a new marker of steroid action in these cancer cells, and whether the sex steroid-induced stimulation of apo D secretion coincides with inhibition of cell proliferation. We took advantage of the biphasic pattern of the effect of steroids on the proliferation of the human prostate cancer LNCaP cell line, which offers the opportunity to discriminate between positive and negative steroid receptor-regulated cell growth processes. A 10-day exposure to low concentrations of dihydrotestosterone and testosterone caused a potent stimulation of LNCaP cell proliferation, whereas incubation with higher concentrations of these androgens led to a progressive decrease in cell proliferation towards basal levels. The biphasic action of androgens was also observed on apo D secretion, the effects on apo D secretion being inversely related to their action on LNCaP cell proliferation. Similar opposite biphasic effects were also observed with 9 other steroids, thus indicating that the stimulation of secretion of this new biochemical marker coincides with inhibition of cell proliferation in LNCaP human prostatic cancer cells.
Stress and structural damage sensing piezospectroscopic coatings validated with digital image correlation (2015)

The piezospectroscopic effect, relating a material’s stress state and spectral signature, has recently demonstrated tailorable sensitivity when the photo-luminescent alpha alumina is distributed in nanoparticulate form within a matrix. Here, the stress-sensing behavior of an alumina-epoxy nanoparticle coating, applied to a composite substrate in an open hole tension configuration, is validated with the biaxial strain field concurrently determined through digital image correlation. The coating achieved early detection of composite failure initiation at 77% failure load, and subsequently tracked stress distribution in the immediate vicinity of the crack as it progressed, demonstrating non-invasive stress and damage detection with multi-scale spatial resolution.
SVEF: an open-source experimental evaluation framework for H.264 scalable video streaming (2009)

This paper describes the H.264 scalable video coding streaming evaluation framework (SVEF). This is the first open-source framework for experimental assessment of H.264 scalable video coding (SVC) delivery over real networks. Effectively adapting of the transport of an H.264 SVC stream to time-varying, bandwidth constrained, and loss prone networks is an important research area. However, very little experimental work has been performed due to the unavailability of real-time H.264 SVC players, the limitations of existing decoding software libraries when challenged with network-imparied received SVC streams (e.g., affected by random loss of Network Abstraction Layer Units - NALUs), and the lack of solutions for SVC streaming support. SVEF overcomes these issues by developing missing components and by integrating them in a hybrid online/offline experimental framework. We believe SVEF will be of significant help to the research community interested in experimentally benchmarking their own proposed SVC adaptation approaches and delivery mechanisms. As a proof-of-concept of SVEF, we provide the experimental performance evaluation of an SVC cross-layer in-network scheduler in a wireless LAN hot spot scenario.
Single‐Feature Polymorphism Mapping in Bread Wheat (2009)

Probe hybridization data from the Affymetrix GeneChip platform can be used to identify genetic polymorphisms. Developed from gene expression data, these single‐feature polymorphism (SFP) markers are located in or are tightly associated with gene sequences. Using two different methods to identify SFPs, 1035 and 875 SFPs were mapped in a segregating population of 64 doubled haploid lines from the Triticum aestivum L. cross RL4452 × ‘AC Domain’. Statistical associations between the SFP maps and the rice ( Oryza sativa L. ssp. japonica ) genome were in agreement with known cereal syntenic blocks, and the mapping data were corroborated by previously established physical locations for wheat expressed sequence tags. This approach allowed the rapid identification of markers from the genic regions of the complex hexaploid wheat genome.
Modeling and Signal Processing of Acoustic Gunshot Recordings (2006)

Audio recordings of gunshots can provide information about the gun location with respect to the microphone(s), the speed and trajectory of the projectile, and in some cases the type of firearm and ammunition. Recordings obtained under carefully controlled conditions can be well-modeled by geometrical acoustics. Special acoustic processing systems for real time gunshot detection and localization are used by the military and law enforcement agencies for sniper detection. Forensic analysis of audio recordings is also used to provide evidence in criminal and civil cases. This paper reviews the distinctive features and limitations of acoustic gunshot analysis using DSP techniques
Short-term effects of carbohydrates differing in glycemic index (GI) consumed at lunch on children’s cognitive function in a randomized crossover study (2020)

No evidence of short-term effects of lunch dietary GI on cognition of schoolchildren was found. Potential positive effects on single parameters of working memory updating and tonic alertness favoring hGI rice need to be verified.
A Theory of Memory Models (Extended Abstract) (2006)

A memory model for a concurrent imperative programming lan-guage specifies which writes to shared variables may be seen by reads performed by other threads. We present a simple mathemat-ical framework for relaxed memory models for programming lan-guages. To instantiate this framework for a specific language, the designer must choose the notion of atomic steps supported by the language (e.g. 32-bit reads and writes) and specify how a composite step may be broken into a sequence of atomic steps (the decompo-sition rule). This rule determines which sequence of intermediate writes (if any) are visible to concurrent reads by other threads. Dif-ferent choices of the rule lead to models which permit a read to re-turn any value if there is a concurrent write (race), or models which satisfy a “No Thin Air Read ” property. The former is suitable for languages such as C++ (programs with races have undefined behav-ior), and the latter for Java. Other intermediate models are possible, useful and interesting. We establish that all models in the framework satisfy the Fun-damental Property of relaxed memory models: programs whose se-quentially consistent (SC) executions have no races must have have only SC executions. We show how to define synchronization con-structs (such as volatiles of various kinds) in the framework, and discuss the causality test cases from the Java Memory Model.
Synergistic effect of zeolite in an intumescence process. Study of the interactions between the polymer and the additives (1996)

The chemical effect of the zeolite 4A added to the intumescent ammonium polyphosphate (APP)–pentaerythritol (PER) system in a fire retardant (FR) ethylene–butyl acrylate–maleic anhydride terpolymer (LRAM3.5)-based formulation has been studied. Thermogravimetric (TG) analysis defines the different steps of the degradation of the formulation and shows that the presence of the zeolite leads to an increase in the stability of the material at high temperature (T > 550 °C). Spectroscopic characterisations, mainly 31P, 13C, 1H and 27Al NMR of the solid state, demonstrate that there are interactions between the polymer and the additives. In the case of the LRAM3.5–APP–PER formulation, the protection arises principally from the additives which make a thermal barrier between the flame and the material. When zeolite is present it plays an essential role, because it allows the formation of structures stabilising the polymer which can then participate in the formation of the intumescent protective shield and hence in its own protection. Moreover, we prove that the FR properties of the protective material obtained from the formulations depend on the ‘quality’ of the intumescent coating obtained from the additives. In particular, the presence of the zeolite decreases the size of the amorphous domains of the carbon.
Avoid the kinks when measuring mobility (2016)

Transistor measurements can overstate organic semiconductor charge carrier mobility
5 kV 4H-SiC SEJFET with low RonS of 69mΩcm/sup 2/ (2003)

A normally-off type 5.3 kV 4H-SiC JFET with low specific on-resistance, called a SEJFET (Static Expansion channel JFET), has been fabricated. By an adoption of area-efficient cell structure and a proper JTE termination (Junction Termination Extension), high performance is realized. The specific on resistance (RonS) is 69 m/spl Omega/cm/sup 2/ and the turn off time is 47 ns. The highest current capability is 3.3 A. In all reported FETs, the SEJFET has the best trade-off between RonS and blocking voltage (BV), which is about 1/230/sup th/ lower than theoretical limit of a Si FET. Furthermore, the figure of merit (BV/sup 2//RonS) is 407MW/cm/sup 2/, and this value is the highest among reported normally off SiC FETs.
ChemInform Abstract: THE FORMATION OF TRAPPED ELECTRONS UPON THE THERMAL DEHYDRATION‐CONDENSATION OF HYDRATED HYDROGENORTHOPHOSPHATES (1979)

Abstract Hydratisierte Hydrogenorthophosphate wie z.B. NaH 2 PO 4 ·2 H 2 O, Ca(H 2 PO 4 ) 2 · H 2 O oder Mg(H 2 PO 4 ) · 2 H 2 O verfärben sich im Verlaufe ihrer thermischen Dehydratisierung‐Kondensation, die zu Pyro‐ oder Metaphosphat führt, grau.
PNA synthesis using a novel Boc/acyl protecting group strategy (2001)

The synthesis of novel Boc/acyl protected monomers for the synthesis of peptide nucleic acid (PNA) is described. The oligomerization protocol using these new monomers has been optimized with regard to coupling reagents. The use of base-labile acyl protecting groups at the exocyclic amines of the heterocyclic bases (isobutyryl for guanine and benzoyl for adenine and cytosine) and a PAM-linked solid support offers an attractive alternative to the present procedures used in PNA synthesis. This strategy has been applied for the synthesis of a test 17mer PNA on both control pore glass (CPG) and a polystyrene MBHA support and was used in the preparation of PNA-DNA chimeras.
Synergistic apoptotic effect of miR-183-5p and Polo-Like kinase 1 inhibitor NMS-P937 in breast cancer cells (2021)

MicroRNAs (miRNAs) are small noncoding RNAs that act as endogenous regulatory molecules targeting specific mRNAs for translational repression. Studies of breast cancer genomics indicate that breast cancer subtypes are distinguished and regulated by specific sets of miRNAs which affect activities such as tumor initiation, progression, and even drug response. Polo-like Kinase 1 (PLK1) is widely considered to be a proto-oncogene due to its increased expression in multiple tumor types, as well as its crucial role in regulating mitosis. Pharmacological inhibition of PLK1 can reduce tumor volume and induce tumor cell death in solid and hematologic malignancies. This prompted us to investigate how PLK1 inhibition with the target-specific inhibitor NMS-P937 would impact breast cancer cells, and how miRNAs may influence the overall response of these cells to this inhibition. We found that miR-183-5p targets PLK1 gene, effectively reducing its protein expression. Such miRNA-driven regulation of PLK1 expression sensitizes breast cancer cells to NMS-P937, resulting in synergistically increased apoptosis. We also show that the miRNA-regulated reduction of PLK1 influences the expression of apoptosis-related key proteins and possibly inducing further indirect PLK1 downmodulation through a DNMT1-p53 axis. These results suggest a potential biologically significant link between the expression of miR-183-5p and the efficacy of PLK1-specific inhibitors in breast cancer cells. Our work further elucidates how miR-183-5p regulates PLK1 gene while also enhancing NMS-P937 effect in breast cancer. Future studies assessing the role of miR-183-5p as a novel biomarker for anti-PLK1 chemotherapy agents are warranted.
PREDICTION OF TEMPERATURE VARIATION IN AN EXPERIMENTAL BUILDING (2011)

Godkänd; 2011; 20111018 (ysko)
Clinical and Prognostic Relevance of Cardiac Wasting in Patients With Advanced Cancer (2023)

Low LV mass is associated with poor functional status and increased all-cause mortality in cancer. These findings provide clinical evidence of cardiac wasting-associated cardiomyopathy in cancer.
<title>Fast JPEG encoding for color fax using HVQ</title> (2000)

We derive a JPEG compliant image compressor which is based on hierarchical vector quantization (HVQ). The goal is to reduce complexity while increasing compression speed. For each block, the DCT DC coefficient is encoded in the regular way while the residual is mapped through HVQ to a pre-computed bit-stream corresponding to the compressed DCT AC coefficients. Approximation quality is generally good for high compression ratios. Color Fax is the primary application target for the proposed system.
Radio resource management in femtocell downlink exploiting location information (2011)

Femtocells (HeNB) deployed within macrocells (MeNB) coverage area may use the same spectrum for communication, causing interference on both MeNB users (MUE) and other HeNB users (HUE). Under this scenario, radio resource management (RRM) is a challenging task to mitigate the interference on both the users. In order to minimize this, we propose an interference-aware local cartography-based RRM (LC-RRM) technique for HeNB with the knowledge of corresponding HUEs location. In particular, with the measured interference values on each resource block (RB) at existing HUEs location, we compute interference cartography (IC) diagram for HeNB coverage area using spatial interpolation algorithm. Using IC diagram, HeNB applies interference classification algorithm to classify the RBs and uses them according to the proposed dynamic fractional frequency reuse (FFR) scheme at desired location, and uses them for transmission with appropriate transmit power without producing interference above the critical values at both MUEs and neighbouring HUEs. Our analysis reveals that the proposed approach achieves higher throughput than interference-unaware RRM techniques, while the interference introduced to the MUE remains within a tolerable limit.
High‐Performance n‐Type Organic Electrochemical Transistors Enabled by Aqueous Solution Processing of Amphiphilicity‐Driven Polymer Assembly (2022)

Abstract Despite the growing attention on organic electrochemical transistors (OECTs), most research has focused on the design of p‐type active materials, and the number of high‐performance n‐type materials is limited. Herein, a series of naphthalene diimide‐based polymers incorporated with asymmetrically branched oligo(ethylene glycol) (OEG) side chains are developed to enable green‐solvent‐processed, high‐performance n‐type OECTs. The branched OEG side chains afford sufficient solubility in eco‐friendly ethanol/water solvent mixtures. Importantly, taking advantage of the amphiphilic nature of OEG‐based polymers, ethanol/water solvents selectively solvate hydrophilic OEG side chains, while producing assembled π−π stacks of hydrophobic backbones. This enables highly ordered polymer packing with a preferential edge‐on orientation, and thus excellent lateral charge transport. In particular, the fine‐tuned OEG side chains of P(NDIMTEG‐T) provide compact backbone packing, effective polaron generation, and superior electrochemical stability with optimized swelling capability. The resultant n‐type OECT shows the best electrical/electrochemical performance in the family, represented by a high transconductance ( g m ) of 0.38 S cm −1 and a large figure‐of‐merit (µ C *) of 0.56 F V −1 cm −1 s −1 . This study demonstrates the use of aqueous processing in OECTs, for the first time, and suggests important guidelines for the design of n‐type organic mixed ionic‐electronic conductors with excellent OECT characteristics.
Strategic Virtualized-Elastic-Regenerator Placement and Adaptive Modulation Selection for Translucent Elastic Optical Networks (EONs) (2019)

We show that strategic virtualized-elastic-regenerator (VER) placement, which considers node-degree and node-separation in the regeneration-site selection, and adaptive modulation mitigate excessive link congestion while lowering the necessary number of VERs in a translucent EON.
Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo (2011)

The spleen tyrosine kinase (Syk) is a key mediator of immunoreceptor signaling in immune cells. Thus, interfering with the function of Syk by genetic deletion or pharmacological inhibition might influence a variety of allergic and autoimmune processes. Since conventional Syk knockout mice are not viable, studies addressing the effect of Syk deletion in adult animals have been limited. To further explore functions of Syk in animal models of allergy and to shed light on the role of Syk in the in vivo migration of neutrophils and monocytes, we generated inducible Syk knockout mice. These mice harbor a floxed Syk gene and a tamoxifen-inducible Cre recombinase under the control of the ubiquitously active Rosa26-promoter. Thus, treatment of mice with tamoxifen leads to the deletion of Syk in all organs. Syk-deleted mice were analyzed in mast cell-dependent models and in models focusing on neutrophil and monocyte migration. We show that Syk deletion in adult mice reduces inflammatory responses in mast cell-driven animal models of allergy and asthma but has no effect on the migration of neutrophils and monocytes. Therefore, the inducible Syk knockout mice presented here provide a valuable tool to further explore the role of Syk in disease-related animal models.
Impact of power system partitioning on the efficiency of distributed multi-step optimization (2017)

Recent studies have shown that multi-step optimization based on Model Predictive Control (MPC) can effectively coordinate the increasing number of distributed renewable energy and storage resources in the power system. However, the computation complexity of MPC is usually high which limits its use in practice. To improve the efficiency of MPC, in this paper, we apply a distributed optimization method to MPC. The approach consists of a partitioning technique based on spectral clustering that determines the best system partition and an improved Optimality Condition Decomposition method that solves the optimization problem in a distributed manner. Results of simulations conducted on the IEEE 118-bus system show that the distributed MPC problem can be solved significantly faster by using a good partition of the system and that this partition is applicable to multiple time steps without frequent changes.