gebhart/patrepeval huggingface dataset:
Supplementary Figure 5 from Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response (2023)

&lt;p&gt;Kaplan-Meier curves for survival differences between investigated chemotherapeutic regimens after stratification for molecular subtype of PDAC. P-values calculated by log rank test.&lt;/p&gt;
A Case of Large-Intestine Signet Ring Cell Carcinoma with Prostatic Metastasis and Long-term 2-year Survival (2011)

症例は51歳の男性で，2006年11月より前立腺印環細胞癌の診断の下，放射線治療およびホルモン療法を施行されていた．2007年6月頃よりイレウス症状を認め，下部消化管内視鏡にて回盲部末端にbridging fold様に見える部位を伴う腫瘍を認め，印環細胞癌が検出された．手術所見では腹腔内は広範に腹膜播種を来しており，根治性はなくイレウス解除を目的に回盲部切除を施行した．病理所見では免疫染色で盲腸，前立腺の腫瘍共にサイトケラチン20（CK20）（+），サイトケラチン7（CK7）（-），前立腺特異抗原（PSA）（-）であることから，盲腸原発の印環細胞癌の前立腺転移であると考えられた．術後化学療法にFOLFOX+bevacizumab，FOLFIRIを行い，24か月の無症状生存期間を得，27か月目に原病死された．大腸癌の前立腺転移の報告例は自験例が本邦2例目であり文献的考察を加え報告する．
Un dysfonctionnement des cordes vocales d'origine professionnelle ? (2008)

Notre attention a ete attiree recemment par un cas de dysphonie intriquee a un asthme professionnel chez une employee d'une graineterie. La visualisation a la fibroscopie d'un mouvement paradoxal des cordes vocales nous a fait evoquer la possibilite d'un dysfonctionnement des cordes vocales du aux irritants. Cette entite recemment decrite est commentee ici. Le dysfonctionnement des cordes vocales non du a des irritants entraine une multitude de signes cliniques lors des crises, a type de toux, souffle court et plus rarement enrouement, dysphonie, poitrine oppressee et difficultes a avaler. Une toux chronique ou un enrouement isoles comme dans notre cas peuvent etre les seules manifestations observees. Divers facteurs declenchant ont ete evoques. La forte ressemblance clinique a l'asthme fait toute la difficulte de cette pathologie. Un retard diagnostic de 4,8 ans en moyenne lorsque le dysfonctionnement est isole a pu etre observe. Ce probleme est frequent puisque 56 % des 95 cas de dysfonctionnement des cordes vocales etudies par Newman etaient associes a un asthme. Le diagnostic est authentifie grâce a la fibroscopie laryngee directe, indirecte, ou, mieux, une video-laryngoscopie qui permet l'observation d'une fermeture paradoxale des cordes vocales au cours du cycle respiratoire des deux-tiers anterieurs avec persistance de l'ouverture d'un losange posterieur larynge. Une fois le diagnostic pose, l'approche therapeutique consiste dans tous les cas a rassurer le patient. A long terme, la prise en charge consiste en seances d'orthophonie basee sur l'apprentissage de la respiration diaphragmatique, de maniere a ne plus etre focalise sur le larynx, et en entretiens psychologiques lorsque l'on suspecte un terrain favorable.
Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity (2011)

ABT-737 and ABT-263 are potent inhibitors of the BH3 antiapoptotic proteins, Bcl-x(L) and Bcl-2. This class of putative anticancer agents invariantly contains an acylsulfonamide core. We have designed and synthesized a series of novel quinazoline-based inhibitors of Bcl-2 and Bcl-x(L) that contain a heterocyclic alternative to the acylsulfonamide. These compounds exhibit submicromolar, mechanism-based activity in human small-cell lung carcinoma cell lines in the presence of 10% human serum. This comprises the first successful demonstration of a quinazoline sulfonamide core serving as an effective benzoylsulfonamide bioisostere. Additionally, these novel quinazolines comprise only the second known class of Bcl-2 family protein inhibitors to induce mechanism-based cell death.
E.P.R. Experiment in oriented Fe8 Molecular Nanomagnets: Mesoscopic Quantum Coherence in High-Spin Molecules (1998)

We report observation of coherent quantum oscilations in spin-10 Fe8 molecular clusters. The powder of magnetically oriented Fe8 crystallites was placed inside a resonator, in a dc magnetic field perpendicular to the magnetization axis. The field dependence of the ac-susceptibility was measured up to 5 T, at 680 MHz, down to 25 mK. Two peaks in the imaginary part of the susceptibility have been detected, whose positions coincide, without any fitting parameters, with the predicted two peaks corresponding to the quantum splitting of the ground state in the magnetic field parallel and perpendicular to the hard magnetization axis.
Open Reduction Internal Fixation and Primary Total Hip Arthroplasty of Selected Acetabular Fractures (2009)

Treatment of acetabular fractures remains challenging particularly in the presence of severe osteopenia, comminution, or associated femoral head fracture. In appropriately selected patients, ORIF and primary THA provide an acceptable treatment option.
Pathogenesis of herpesviruses in lower vertebrates: influence of ictalurid herpesvirus 1 (IcHV-1) on macrophage and lymphocyte activities in fish (2010)

Interest of lower vertebrates viruses has recently increased for a variety of reasons despite the fact that none of them infect warm-blooded animals and man. Several DNA viruses infecting fish have been studied for analysis the pathogenesis and for developing the effective methods of prevention and therapy. In this paper, we present the in vitro influence of ictalurid herpesvirus-1 (IcHV-1) on the phagocytic activity of splenic macrophages and proliferative response of pronephric lymphocytes stimulated by mitogens ConA and LPS isolated from wels catfish (Silurus glanis) and tench (Tinca tinca). The results showed that IcHV-1 induced suppressive influence on the phagocytic ability of splenic macrophages in wels catfish, compared to the tench. Also the results showed that IcHV-1 decreased the proliferative response of pronephros lymphocytes stimulated by mitogens ConA in wels catfish, compared to the tench where the immunostimulating effect was observed. The analyses of this study suggested that IcHV-1 inhibited of cell-mediated immunity only in wels catfish.
Electroforming of Copper Structures at Nanometer-Sized Gaps of Self-assembled Monolayers on Silver (2002)

This paper describes a method to fabricate micro- and nanostructures of copper by electrodeposition onto nanometer-sized gaps in self-assembled monolayers (SAM) of alkanethiolates on metal surfaces. We have demonstrated that the approach can produce large numbers of metallic micro- or nanostructures over large (2 cm2) areas with features as small as ≈70 nm. The electrodeposited copper structures can be transferred using Scotch tape onto both flat and curved substrates. Linear arrays of copper structures have been tested for use as optical polarizers. A polarization ratio R = ≈2.0 was found for light with λ = 633 nm in transmission mode for linear arrays of copper wires (≈220 nm, with a 1-μm pitch) mounted on antireflective windows.
Using the Processing Programming Environment in Engineering Education (2020)

There I worked on the Learning Applied to Ground Robotics project, developing a ground vehicle that can not only navigate unknown terrain, but be able to learn from
Feasibility of Aeration for Management of Maize Weevil Populations in Corn Stored in the Southern United States: Model Simulations Based on Recorded Weather Data (1998)

Recorded data from weather stations in 11 southern states were used to determine the optimum initial activation temperatures for immediate cooling of corn that is stored after harvest. Hours of temperature accumulation in September and October that were below 12.8 and 15.6C (55 and 60 OF),levels that often are recommended for fall cooling of hard red winter wheat stored in the midwestern United States, were calculated and plotted, along with hours of accumulation below 18.3 C (65F). Five geographic zones were delineated based on weather data from 53 stations; and a bin-cooling model, which was integrated with a model for maize weevil development, was used to predict weevil population growth in unaerated corn and corn aerated at 12.3, 15.6, and 18.3C with airflow rates of 0.0013, 0.0026, and 0.0039 m 3/s/m 3 (0.1, 0.2, 0.3 cubic feet per minute per bushel). The time required to compete a cooling cycle within each region was estimated for each of the 9 temperature-airflow rate combinations. Aeration at 15.6 or 18.3C, depending on the geographic zone, and an airflow rate of 0.0013 m 3/s/m 3 resulted in the lowest number of maize weevils. In all zones, aeration dramatically reduced the predicted number of maize weevils compared to population levels in una erated corn.
Relative loss rate differentiation: performance of short-lived TCP flows (2004)

The relative differentiated service model provides assurances for the relative quality ordering between service classes, rather than for the actual service level in each class. In this paper, we describe a relative loss rate differentiation scheme where packet drop probabilities are determined according to an active queue management (AQM) mechanism based on random early detection (RED) in a first-in first-out (FIFO) queue, are weighted in inverse proportion to the price that the network operator assigns to each service class. Basically, we describe a scheme where relative loss rate differentiation is incorporated directly into AQM. Most TCP flows today, particularly Web flows, can be characterized as short-lived flows. Using simulations with short-lived TCP flows, we show that the scheme is very effective in ensuring relative loss rate differentiation between service classes during times of network congestion. Copyright © 2004 John Wiley & Sons, Ltd.
Device, circuit and system-level analysis of noise in multi-bit phase-change memory (2010)

We present a comprehensive investigation of noise in multi-bit phase-change memory (PCM). The impact of noise on data integrity was quantified with a combination of experiments and simulations. A prototype chip was fabricated to support our system-level analysis, which shows that a raw bit error rate of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> is achievable at 3-bit/cell. At the circuit level, we identified the bit line capacitance and the voltage regulator noise as the critical elements determining the electronic readout circuit noise. In addition, device-level measurements showed that 80% of the total noise can be traced back to the fluctuations in the PCM cell current itself. Our analysis captures for the first time how these fluctuations ultimately limit the achievable bit error rate in future multi-level-cell (MLC) PCM chips.
Mesure de Trajectoire par Stéréo-Vision pour des Applications de Suivi de Véhicules à Basse Vitesse (2007)

National audience
Optimization of an electret-based electrostatic energy scavenger (2010)

International audience
Importance of Disordered Polymer Segments to Microstructure-Dependent Photovoltaic Properties of Polymer–Fullerene Bulk Heterojunction Solar Cells (2011)

While regulation of the nanoscale microstructure of the active layers in organic bulk heterojunction (BHJ) solar cells, particularly for conjugated polymer–fullerene blend systems, has been shown to be highly important when maximizing power conversion efficiency, little is known about the role of disordered polymer chains in the photovoltaic (PV) behaviors and electrochemical potential drops of polymer–fullerene interfaces. In this study, the microstructural-dependent PV properties of a series of poly(3-hexylthiophene) (P3HT):fullerene (i.e., [6,6]-phenyl-C61-butyric acid methyl ester, or PCBM) blending films with different compositions have been investigated using several experiments (i.e., absorption spectroscopy, Raman spectroscopy, X-ray diffraction, and atomic force microscopy) and theoretical methods (i.e., spectroscopic simulation and quantum mechanical calculations). A strong correlation exists between amorphous P3HT chain properties, characterized by degree of conjugation (Leff), and PV parameters. The impact of Leff of amorphous P3HT on exciton dissociation is addressed, thus providing an ideal structural model for organic BHJ solar cells. Although bigger P3HT and PCBM domains favor carrier transport, the control of disordered P3HT segments and PCBM contact is crucial to exciton dissociation, which can consequently optimize PV performance.
A 16-Channel 13C Array Coil for Magnetic Resonance Spectroscopy of the Breast at 7T (2021)

Development of the 16-channel breast array coil opens possibilities of in vivo lipidomics studies to elucidate the link between breast cancer incidence and lipid metabolics.
Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-κB and the glucocorticoid receptor (2000)

Negative transcriptional regulation or cross-coupling between NF-kappa B (RelA) and the glucocorticoid receptor (GR) is proposed to play a regulatory role in human physiology and disease. Despite previous advances, the biochemical basis of this phenomenon remains a subject of controversy. We show here that the inhibition of GR activity by RelA does not require the RelA DNA binding, transactivation, or nuclear localization domains. Surprisingly, RelA repression of GR is abolished by mutation of the conserved protein kinase A (PKA) site at amino acid residue 276 of RelA. We show that GR associates in vivo and in vitro with the catalytic subunit of PKA (PKAc) in a ligand-independent manner and that GR transcription depends on PKA signaling. Indeed, we demonstrated that GR-mediated inhibition of NF-kappa B transactivation is PKAc-dependent. In contrast to previous models, we suggest that the cross-coupling requires a cytoplasmic step and is regulated by a PKAc-associated signaling.
Novel procedure- and device-based strategies in the management of systemic hypertension (2011)

Despite the considerable advances in the treatment of hypertension that have been made over the past few decades, adequate management and control of this condition remains poor, and efforts are ongoing to develop new strategies to improve related outcomes. Novel therapeutic approaches to the management of systemic hypertension fall into two major categories: (i) those that seek to improve blood pressure-lowering efficacy using new therapeutic strategies in addition to standard non-pharmacological and pharmacological approaches and (ii) novel ways to optimize and improve the efficacy and utility of existing therapies. Novel procedure- and device-based strategies to control hypertension include renal sympathetic denervation and baroreflex sensitization. These two techniques will be the focus of the present review.
Gonadoblastoma (1987)

We report a patient with a disorder of sexual differentiation who presented with a 46,XY karyotype, absent internal Müllerian ducts, a vaginal pouch, hypospadias, and bilateral cryptorchidism with a gonadoblastoma in one testis. A human chorionic gonadotropin stimulation test and tissue 5-alpha-reductase and androgen receptor assays were normal. Except for the absence of internal Müllerian ducts, this patient most closely resembles the disorder of dysgenetic male pseudohermaphroditism (DMP). On this basis, we hypothesize that the internal Müllerian ducts in DMP may manifest anywhere along a spectrum that extends from normal to complete absence of structures depending on the degree of gonadal dysgenesis. This case also illustrates the importance of testicular biopsy in patients with dysgenetic testes because of the high likelihood of germ cell neoplasms in these gonads.
Poly(vinyltriethoxysilane) modified MWCNT/polyimide nanocomposites—Preparation, morphological, mechanical, and electrical properties (2007)

Abstract Multi‐walled carbon nanotube (MWCNT) modified by vinyltriethoxysilane (VTES) via free radical reaction has been prepared (poly (vinyltriethoxysilane) modified MWCNTs, PVTES‐MWCNT). Precursor of polyimide, polyamic acid has been synthesized by reacting 4,4′‐oxydianiline with 3,3′,4,4′‐benzophenone tetracarboxylic dianhydride. PVTES‐MWCNT were then mixed with polyamic acid and heated to 300 °C to form CNT/polyimide composite. During the imidization processes, the silanes on CNT surface reacted with each other and may be connected together by covalent bond (SiOSi). The PVTES‐MWCNT was analyzed by Fourier transform infrared and X‐ray photoelectron spectroscopy. The PVTES‐MWCNT/polyimide composites were analyzed by CP/MAS solid state 29 Si nuclear magnetic resonance (NMR) spectroscopy. Morphological properties of the PVTES‐MWCNT/polyimide composites were investigated by scanning electron microscope and transmission electron microscope. Electrical conductivity increased dramatically comparing to the unmodified MWCNT/polyimide composites. Mechanical properties of nanocomposite were enhanced significantly by PVTES‐MWCNT. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 803–816, 2008
Shift- and rotation-invariant object reconstruction using the bispectrum (1992)

Triple correlations and their Fourier transforms, called bispectra, have properties desirable for image-sequence analysis and reconstruction. Specifically, the triple correlation of a two-dimensional sequence is shift invariant, vanishes for symmetric probability-distribution-function processes including Gaussian random processes of unknown covariance, and can be used to recover the original sequence uniquely to within a linear phase shift. Discrete analysis is carried out for a deterministic signal in an additive random-noise field. This approach yields discrete algorithms for implementation and permits explicit treatment of the additive noise. Recursive and least-squares fast-Fourier-transform-based algorithms for reconstructing a two-dimensional discrete Fourier transform from the bispectrum are reviewed in detail. While phase retrieval using the least-squares algorithm requires phase unwrapping, the recursive method requires a more simple correction. The bispectrum is applied to the estimate of a randomly translating or rotating object from a sequence of noisy images. The technique does not require solution of the correspondence problem, which is the primary advantage. The method works in low signal-to-noise-ratio cases, when conventional solutions to estimating the object correspondence may fail. Experimental results presented include application of the method to a sequence of infrared images.
Plasma NT-proBNP increases in response to LPS administration in healthy men (2008)

Circulating levels of B-type natriuretic peptide (BNP) and NH(2)-terminal-proBNP (NT-proBNP) increase in response to volume overload and help in the differential diagnosis of acute heart failure. Elevated plasma BNP levels are observed also in sepsis and do not always correspond to left ventricular dysfunction. Here, we investigated plasma NT-proBNP fluctuations in response to human bacterial endotoxinemia, an experimental model of systemic infection and inflammation. Escherichia coli endotoxin (LPS) (2 ng/kg) was administered to 10 healthy volunteers in a randomized, placebo-controlled, cross-over design. Plasma NT-proBNP, C-reactive protein (CRP), COOH terminal pro-endothelin-1 (CT-proET-1), and midregional-pro-adrenomedullin (MR-proADM) were measured at hourly intervals for 6 h. LPS administration induced a continuous increase in plasma NT-proBNP that reached peak values after 6 h (40.7 +/- 7.9 vs. 16.1 +/- 3.2 pg/ml in placebo days, mean +/- SE; P = 0.023). The profile of changes in NT-proBNP correlated to changes in body temperature (P < 0.001), heart rate (P = 0.005), CRP (P < 0.001), and CT-proET-1 (P = 0.008), but not to blood pressure values. Our results demonstrate that plasma NT-proBNP increases in a model of systemic infection/inflammation in healthy men with normal heart function. This finding emphasizes the necessity to consider concomitant infections when interpreting elevated circulating NT-proBNP concentrations.
Optimization of a finned heat sink array based on thermoeconomic analysis (2006)

The design and specification of heat sinks for electronic systems is not easily accomplished through the use of standard thermal design and analysis tools since geometric and boundary conditions are not typically known in advance. A second-law based thermoeconomic optimization procedure is presented for a finned heat sink array. This involves including costs associated with material, and irreversible losses due to heat transfer and pressure drop. The influence of important physical, geometrical and unit cost parameters on the overall finned array are optimized for some typical operating conditions that are representative of electronic cooling applications. The optimized cost results are presented in terms of ReD, ReL, λP / λH, and q for a finned system in a graphical form. In addition the methodology of obtaining optimum parameters for a finned heat sink system which will result in minimum operating cost is demonstrated. Copyright © 2006 John Wiley & Sons, Ltd.
Exchange economies and loss exposure: Experiments (1997)

Exchange economies were created in which individuals faced losses. If people are risk seeking in the losses, as predicted by prospect theory, then due to the nonconvexity, the competitive equilibria are all on the boundaries of the Edgeworth box. The experimental results are that risk-seeking behavior is observed in many people and appears in markets as predicted. In addition, market behavior is consistent with answers to hypothetical questionnaires. Contrary to prospect theory, risk seeking seems to diminish with experience: preferences in the market setting are not labile; and risk-seeking preferences are not simply a result of framing effects. Copyright 1997 by American Economic Association.
Hepatic Telangiectasia and Cirrhosis (1988)

In a woman with hereditary hemorrhagic telangiectasia (HHT) (Osler-Weber-Rendu disease) who died of fulminant hepatitis B, autopsy revealed cirrhosis of the liver and diffuse hepatic telangiectasia. Her daughter and grandson also suffered from the hepatic involvement of HHT. Sufficient laboratory investigations were available to exclude known causes of cirrhosis. We review the relationship between Osler-Weber-Rendu disease and liver cirrhosis or fibrosis.
High performance and reliable 1.3 μm InAs quantum dot lasers epitaxially grown on Si (2018)

1.3 μm InAs quantum dot lasers on Si show a CW threshold current of 4.8 mA and extrapolated lifetimes of ten million hours at 35°C and ~65,000 hours at 60°C.
Predictors of Morbidity and Mortality After Colorectal Surgery in Patients With Cirrhotic Liver Disease–A Retrospective Analysis of 54 Cases at a Tertiary Care Center (2022)

Morbidity and mortality after CRS in patients with CLD remains high and is not only influenced by liver function but also by surgical variables. Considering the high rate of anastomotic leakage, creating a protective or definitive ostomy must be considered with regard to the underlying pathology, the extent of CLD, and the patient's condition. Moreover, our data suggest that surgery in these most fragile patients should be performed only in experienced centers with immediate contact to hepatologists and experts in hemostasis.
Synthesis and Structure Determination of Gibberellin-Derived Antheridiogens From Fern Gametophytes of the Lygodium Genus (1995)

Two successful and two unsuccessful synthetic routes are described for the conversion of commercially available fungal gibberellins to the antheridiogen GA73 methyl ester (5), originally isolated from gametophytes of the fern Lygodium japonicum. The more efficient route began with the Birch reduction of either the GA7 derivative (31) or methyl gibberellate 3,13-dimesylate (32) to give the ?1(10),16-diene acid (33), which was converted into the ?1,9-diene acid (40) by means of a four step procedure. This intermediate could be selectively hydrogenated to the ?9-ene derivative which underwent iodolactonization and then elimination of HI to afford enone (29), Wittig methylenation of which furnished the target antheridiogen (5). In addition, (29) was functionalized at C12 by free radical bromination to give access to the 12ß-hydroxy derivative of (5), i.e. (6), a new antheridiogen isolated from Lygodium circinnatum.