gebhart/patrepeval huggingface dataset:
Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10. (1988)

The rat thoracic aortic smooth muscle cell line, A-10, expresses vasopressin receptors of the V1 subtype. Vasopressin treatment of these cells stimulated the release of arachidonic acid and the formation of diacylglycerol and phosphocholine. These responses to vasopressin were inhibited by the V1-specific antagonist SK&F 100273, indicating that these were receptor-mediated phenomena. The mechanisms by which V1 receptors mediate arachidonic acid release appeared to be unaffected by cycloheximide or actinomycin D, suggesting that the release is independent of protein and RNA synthesis. The V1 receptors also appeared to be coupled to a phospholipase C which can hydrolyze phosphatidylcholine, a possible source of the released arachidonic acid. Phosphocholine and diacylglycerol were also generated. The release of arachidonic acid, phosphocholine, or diacylglycerol was not affected by prior treatment of the cells with pertussis toxin (islet-activating protein). Thus, the release of these second messengers is not mediated by the guanine nucleotide-binding protein Gi or other pertussis toxin-sensitive substrates. We conclude that V1 receptors induce the release of arachidonic acid and the formation of diacylglycerol and phosphocholine via the activation of both a phosphatidylinositol- and phosphatidylcholine-specific phospholipase C.
Shift Scheduling for Third Level IT Support: Challenges, Models and Case Study (2007)

Outsourcing IT support of an enterprise requires that third level IT support is provided as a service by the outsourcer. Although there is a large body of existing work regarding demand forecasting and shift schedule creation for various domains such as call centers, very little work exists for third level IT support. Moreover, there is a significant difference between such support and other types of services. As a result, current best practices for scheduling such work are not based on demand, but rather, on primitive rules of thumb. Due to the increasing number of people providing such support, theory and practice is sorely needed for scheduling third level support shifts according to actual demand. We discuss the issues associated with forecasting and scheduling such work. We also present an end-to-end methodology for forecasting and scheduling this type of work. We discuss this methodology and subsequent results in the context of a specific case study in which this methodology demonstrated significant potential savings in terms of manpower resources.
Insights into the Early Dissolution Events of Amlodipine Using UV Imaging and Raman Spectroscopy (2011)

Traditional dissolution testing determines drug release to the bulk, but does not enable an understanding of the events happening close to the surface of a solid or a tablet. UV imaging is a new imaging approach that can be used to study the dissolution behavior of chemical compounds. The UV imaging instrumentation offers recording of absorbance maps with a high spatial and temporal resolution which facilitates the abundant collection of information regarding the evolving solution concentrations. In this study, UV imaging was used to visualize the dissolution behavior of amlodipine besylate (amorphous and dihydrate forms) and amlodipine free base. The dissolution of amlodipine besylate was faster from the amorphous form than from the crystalline forms. The UV imaging investigations suggested that a solvent mediated phase transformation occurred for the amorphous amlodipine besylate and the amlodipine free base samples. Raman spectroscopy was used to confirm and probe the changes at the solid surface occurring upon contact with the dissolution media and verified the recrystallization of the amorphous form to the monohydrate. The combination of UV imaging and Raman spectroscopy is an efficient tool to obtain a deeper insight into the early events of the dissolution process.
Conformational studies by nuclear magnetic resonanceVI: CC and CN rotation barriers in various enamine derivatives (1973)

Abstract Delocalisation of the nitrogen lone electron pair by an acyl and acylvinylogue group simultaneously, results in a lowering of both CN rotational barriers. MeC(O)CBrCHNMe 2 and MeC(O)C(OCOMe)CHNMe 2 exhibit restricted rotation around what is formally a double bond CC.
Supramolecular Cross-Linking of Thiophenylene Polymers via Multiple Hydrogen Bonds toward High Refractive Index (2023)

Dihydroxy-substituted poly(phenylene sulfide) (DOHPPS) was synthesized via oxidative polymerization of bis(2,6-dimethoxyphenyl) disulfide and subsequent deprotection. The synergistic effect of multiple-hydrogen-bond cross-links and the rigidity of the thiophenylene backbone afforded dense yet amorphous supramolecular networks, resulting in a polymer with visible transparency and an ultrahigh refractive index (nD = 1.85).
Cytokinin oxidase/dehydrogenase inhibitors: outlook for selectivity and high efficiency (2022)

Inhibitors of cytokinin oxidase/dehydrogenase (CKX) reduce the degradation of cytokinins in plants, and this effect can be exploited in agriculture and in plant tissue culture. In this study, we examine the structure-activity relationship of two series of CKX inhibitors based on diphenylurea. The compounds of Series I were derived from the recently published CKX inhibitors 3TFM-2HM and 3TFM-2HE, and we identified key substituents with increased selectivity for maize ZmCKX1 and ZmCKX4a over AtCKX2 from Arabidopsis. Series II contained compounds that further exceled in CKX inhibitory activity as well as in the ease of their synthesis. The best inhibitors exhibited half-maximal inhibitory concentration (IC50) values in low nanomolar ranges with ZmCKX1 and especially with ZmCKX4a, which is generally more resistant to inhibition. The activity of the key compounds was verified in tobacco and lobelia leaf-disk assays, where N6-isopentenyladenine was protected from degradation and promoted shoot regeneration. All the prepared compounds were further tested for toxicity against Caenorhabditis elegans, and the assays revealed clear differences in toxicity between compounds with and without a hydroxyalkyl group. In a broader perspective, this work increases our understanding of CKX inhibition and provides a more extensive portfolio of compounds suitable for agricultural and biotechnological research.
A novel angiotensin II peptide vaccine without an adjuvant in mice (2020)

AJ-Ang II may be a simple and useful therapeutic peptide vaccine without the addition of any adjuvants.
Two-Element Biomimetic Antenna Array Design for Power Extraction / Phase Amplification Tradeoff (2020)

Two-element arrays composed of closely-spaced antennas with mutual coupling have recently been investigated in conjunction with electrical coupling networks that amplify the phase difference in the measurements. These systems have biomimetic analogies to the hearing mechanism in small insects that exhibit exceptional direction finding capabilities. Several coupling networks have been considered with varying complexity and performance relative to the fundamental tradeoff between power extraction and phase difference amplification. In this paper we present a general design method that establishes the achievable region for the power extraction/ phase amplification tradeoff, and we present a four-port Pi coupling network that realizes the entire achievable region. An example illustrates the design method for two closely-spaced dipole antennas at 40 MHz.
Investigating a physically-based signal power model for robust low power wireless link simulation (2008)

We propose deriving wireless simulation models from experimental traces of radio signal strength. Because experimental traces have holes due to packet losses, we explore two algorithms for filling the gaps in lossy experimental traces. Using completed traces, we apply the closest-fit pattern matching (CPM) algorithm, originally designed for modeling external interference, to model signal strength.
Network-on-chip for reconfigurable systems: From high-level design down to implementation (2004)

SCOPUS: ar.k
Ammonia synthesis over Co–Mo alloy nanoparticle catalyst prepared via sodium naphthalenide-driven reduction (2016)

We report the synthesis of Co-Mo alloy nanoparticles with a uniform distribution of the alloy elements on CeO<sub>2</sub>via sodium naphthalenide-driven reduction. The resulting sample functions as a highly efficient and stable catalyst for ammonia synthesis. Based on the metal weight, the catalytic activity is ca. 20 times higher than that of Co<sub>3</sub>Mo<sub>3</sub>N.
Reduced Subset Analysis for Multi-Constellation ARAIM (2014)

Advanced Receiver Autonomous Integrity Monitoring (ARAIM) seeks to exploit the large number of ranging signals provided by the multiplicity of Global Navigation Satellite System (GNSS) core constellations. Including more satellites increases the number of potential fault modes and the number of subset solutions that need to be evaluated by the receiver. In this paper we describe methods for reducing the total number of subsets to be evaluated. This approach neglects many of the less likely scenarios and uses subsets that exclude entire constellations to evaluate other multiple satellite fault scenarios. We further specify which subsets to evaluate given certain ranges for the probability satellite and constellation fault modes. By specifying a reduced number of overall evaluations, and the conditions that separate using one set of subsets versus another, we can dramatically simplify the overall user airborne algorithm. This approach reduces the computational load for each given set of satellite and constellation fault probabilities.
ChemInform Abstract: A Synthesis of the Spiroketal Subunit of (‐)‐Calyculin A. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stacking Interactions: A Supramolecular Approach to Upgrade Weak Halogen Bond Donors (2022)

The co-crystallization of tetracyanobenzene (TCB) with haloarenes ArX provided six new co-crystals TCB ⋅ ArX (ArX=PhCl, PhBr, 4-MeC<sub>6</sub> H<sub>4</sub> Cl, 4-MeC<sub>6</sub> H<sub>4</sub> Br, 4-MeOC<sub>6</sub> H<sub>4</sub> Cl, 1,2-Br<sub>2</sub> C<sub>6</sub> H<sub>4</sub> ) which were studied by X-ray diffraction. In these systems, the strong collective effect of π⋅⋅⋅π stacking interactions and lone pair-(X)⋅⋅⋅π-hole-(C) bondings between TCB and ArX promote the strength of X⋅⋅⋅N<sub>cyano</sub> halogen bonding (HaB). Theoretical studies showed that the stacking interactions affect the σ-hole depth of the haloarenes, thus significantly boosting their ability to function as HaB donors. According to the molecular electrostatic potential calculations, the σ- hole-(Cl) value (1.5 kcal/mol) in the haloarene 4-MeOC<sub>6</sub> H<sub>4</sub> Cl (featuring an electron-rich arene moiety and exhibiting very poor σ-hole-(Cl) ability) increases significantly in the stacked trimer (TCB)<sub>2</sub> ⋅ 4-MeOC<sub>6</sub> H<sub>4</sub> Cl (12.5 kcal/mol). Theoretical DFT calculations demonstrate the dramatic increase of X⋅⋅⋅N<sub>cyano</sub> HaB strength for stacked trimers in comparison with parent unstacked haloarenes.
High-throughput optofluidic profiling of Euglena gracilis with morphological and chemical specificity (2016)

The world is faced with environmental problems and the energy crisis due to the combustion and depletion of fossil fuels. The development of reliable, sustainable, and economical sources of alternative fuels is an important, but challenging goal for the world. As an alternative to liquid fossil fuels, algal biofuel is expected to play a key role in alleviating global warming since algae absorb atmospheric CO2 via photosynthesis. Among various algae for fuel production, Euglena gracilis is an attractive microalgal species as it is known to produce wax ester (good for biodiesel and aviation fuel) within lipid droplets. To date, while there exist many techniques for inducing microalgal cells to produce and accumulate lipid with high efficiency, few analytical methods are available for characterizing a population of such lipid-accumulated microalgae including E. gracilis with high throughout, high accuracy, and single-cell resolution simultaneously. Here we demonstrate a high-throughput optofluidic Euglena gracilis profiler which consists of an optical time-stretch microscope and a fluorescence analyzer on top of an inertial-focusing microfluidic device that can detect fluorescence from lipid droplets in their cell body and provide images of E. gracilis cells simultaneously at a high throughput of 10,000 cells/s. With the multi-dimensional information acquired by the system, we classify nitrogen-sufficient (ordinary) and nitrogen-deficient (lipid-accumulated) E. gracilis cells with a low false positive rate of 1.0%. This method provides a promise for evaluating the efficiency of lipid-inducing techniques for biofuel production, which is also applicable for identifying biomedical samples such as blood cells and cancer cells.
Energy relaying in mobile wireless sensor networks (2013)

In wireless sensor networks, limited battery capacity in each sensor node restricts the reliability of the network. This restriction can be somewhat removed by recharging the node batteries through wireless energy transmission. In a mobile wireless sensor network, if there is only one energy station that can transmit energy, the sensor nodes have to rely on their mobility to receive energy from an energy station. When a node battery is depleted, the node stops activating and stays idle until it recharges its battery. As the number of such idle nodes increases, the reliability of the wireless sensor network will decrease. If energy can be relayed via mobile nodes, a battery-depleted node can recharge its battery with higher rate, which affects the reliability of the network. In this paper, we show that if the energy transmission efficiency exceeds a certain threshold then the reliability of the network can always be improved.
Hydrocarbon and Perfluorocarbon Gas Sorption in Poly(dimethylsiloxane), Poly(1-trimethylsilyl-1-propyne), and Copolymers of Tetrafluoroethylene and 2,2-Bis(trifluoromethyl)-4,5- difluoro-1,3-dioxole (1999)

Sorption of a series of gases, perfluorocarbon vapors (CF4, C2F6, and C3F8) and their hydrocarbon analogues in poly(dimethylsiloxane) [PDMS], poly(1-trimethylsilyl-1-propyne) [PTMSP], and two random copolymers of tetrafluoroethylene [TFE] and 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole [BDD] are reported as a function of penetrant pressure at 35 °C. Sorption isotherms for all penetrants in rubbery PDMS are linear or slightly convex to the pressure axis, while those in the glassy polymers are concave and are well described by the dual mode model. Fluorocarbon sorption levels are lower than sorption levels of their hydrocarbon analogues in the hydrocarbon-based PDMS and PTMSP matrixes, while the reverse is true in the fluorinated TFE/BDD copolymers. Exceptionally low fluorocarbon solubilities in PDMS are ascribed to poor penetrant/polymer energetic interactions.
Decision analysis tools for GENCO dispatchers (1999)

This paper outlines a decision analysis procedure to guide dispatchers in applying corporate policy for economic decisions when risk is involved. These techniques enable dispatchers to implement corporate policies without waiting for an answer from another group or groups within accepted guidelines. The intent of the procedure is to reduce the guidelines to expert system rules, which may be applied without extensive analysis. Such a set of tools is often used in other industries by administrative staff instead of engineering staff. Tools such as the one reported here are needed for the new business environment for profit opportunities to be achieved while maintaining security. The tool described within this paper was designed for a mid-western generation company to handle reserve or contingent contract requests.
Investigation of Self-Assembled Monolayer Resists for Hafnium Dioxide Atomic Layer Deposition (2005)

In this paper, a series of self-assembled monolayers (SAMs) has been investigated as deactivating agents for the atomic layer deposition (ALD) of HfO2. Three important factors that determine the capacity of self-assembled monolayers to prevent ALD of HfO2, chain length, tailgroup structure, and reactive headgroup, have been investigated. We show that to achieve satisfactory deactivation toward atomic layer deposition, it is crucial to form densely packed, highly hydrophobic monolayers. This in turn requires deactivating agents with high reactivity and nonbulky tailgroups comprised of a minimum chain length. A mechanism for the blocking process is proposed in which the role of the SAMs is both to remove reactive Si−OH/Si−O−Si groups at the SiO2 surface and to prevent ALD precursors from reaching the SiO2−SAMs interface.
Imaging through permuted optical probes (2015)

Using time of flight we have enabled an optical brush to calibrate itself and image with its randomly positioned fibers, this offers a flexible field of view and is intrinsically multi-spectral. Therefore, it has potential application for endoscopy, imaging in turbid media and near-field probing.
Properties of Zn-Doped P-Type In0.53Ga0.47As on InP Substrate (1980)

Zn-doping in In 0.53 Ga 0.47 As was investigated. The dependence of the resistivity and Hall mobility of Zn-doped In 0.53 Ga 0.47 As upon the hole concentration is found to be the same as that of Zn-doped In 0.15 Ga 0.85 As. Photoluminescence in Zn-doped In 0.53 Ga 0.47 As is investigated in relation to hole concentration. In 0.53 Ga 0.47 As homojunction diodes are made, and minoritycarrier diffusion lengths of holes and electrons are derived from the EBIC (electron beaminduced current) intensity which is dependent upon the distance from the junction interface.
On the Performance of a Low-Cost K-Band Doppler Radar for Quantitative Rain Measurements (1999)

This paper deals with the ability of a vertically pointing, FM–CW Doppler radar to measure quantitatively raindrop size distributions and rainfall intensity. The wavelength of the radar is 12.5 mm (K band). To improve estimates of the rainfall intensity, radar-received noise, Mie scatter, and radar calibration corrections are applied to the radar data. The electronic noise correction rendered the radar particle size retrievals below 0.7-mm drop diameters invalid; exponential extrapolation of the spectrum below drop diameters of 0.7 mm decreased the rain intensity up to 20%. Proper Mie corrections to the particle backscatter cross sections decreased the rain intensity between 5% and 30%. Calibration of the radar against a Joss–Waldvogel disdrometer led to a decrease in rain intensity of 49%. The electronic noise, Mie scatter, and calibration corrections yielded a correlation coefficient of 0.94 in a comparison of the radar and disdrometer data for a case study. The daily rain sums over half a year derived from radar measurements at a height of 100 m above ground were on average 12% higher than measurements with a conventional Hellmann rain gauge.
Laser-Produced Plasma Light Source Development for Extreme Ultraviolet Lithography (2004)

We present recent results of our laser-produced plasma light source development for next-generation lithography. The plasma target of the extreme ultraviolet (EUV) source system is a liquid xenon jet and the driver laser is a 600 W Nd:YAG laser operating at a repetition rate of 10 kHz. A EUV output power of 2.2 W at 13.5 nm (2% bandwidth, 2π sr) having a stability of 0.72% (1σ, 50-pulse moving average) has been achieved. Related to future collector mirror lifetime considerations, fast ions from the laser-produced plasma have been characterized by time-of-flight (TOF) measurements. Using a low repetition rate 8-ns, 100-mJ Nd:YAG laser Xe + to Xe 6+ ions were observed with Xe 2+ being the main charge state. In addition, the effects of fast ions on Mo/Si multilayer mirrors have been studied using a Xe ion gun. Ion sputtering of the multilayer structure is the main damage mechanism but layer boundary mixing and surface roughness increase are also observed.
PI 3-kinase and disease (2014)

Phosphoinositide 3-Kinase (PI3K) is a central enzyme in a signaling pathway that mediates cellular responses to insulin and other growth factors. This enzyme phosphorylates the 3 position of phosphatidylinositol-4,5-bisphosphate to produce phosphatidyl-inositol-3,4,5-trisphosphate (PIP 3 ) at the plasma membrane. A number of signaling proteins, including the Ser/Thr protein kinases, AKT and PDK1, contain pleckstrin homology domains that bind specifically to PIP 3 . Thus, the generation of PIP 3 at the plasma membrane in response to activation of PI3K by growth factors results in the initiation of downstream Ser/Thr phosphorylation cascades that control a variety of cellular responses. The signaling pathway downstream of PI3K is highly conserved from worms and flies to humans and genetic analysis of the pathway has revealed a conserved role in regulating glucose metabolism and cell growth. Based on deletion of genes encoding the catalytic or regulatory subunits of PI3K in the mouse, PI3K mediates insulin dependent regulation of glucose metabolism, and defects in activation of this pathway result in insulin resistance. In contrast, mutational events that lead to hyperactivation of the PI3K pathway result in cancers. Activating mutations in PIK3CA, encoding the p110alpha catalytic subunit of PI3K or inactivating mutations in PTEN, a phosphoinositide 3-phosphatases that reverses the effects of PI3K, are among the most common events in solid tumors. PI3K driven tumors are FDG-PET positive and turning off PI 3-Kinase with PI3K inhibitors that are in human clinical trials results in an acute decline in FDG-PET signal that precedes tumor shrinkage. Importantly, there is increasing evidence that some tumors express high levels of insulin receptor and activate PI3K due to elevated serum insulin in patients with insulin resistance. These results suggest that elevations in serum insulin may partially explain the link between obesity, diabetes and cancers. The role of PI3K inhibitors for treating cancers in mouse models and in human trials will be discussed.
Transverse fracture toughness of transparent wood biocomposites by FEM updating with cohesive zone fracture modeling (2022)

Little is known about fracture toughness of monomer-impregnated wood biocomposites, with no data for transparent wood. For building applications, toughness is important, but the anisotropic nature of wood generates complex stress distributions that needs to be accounted for. A four-point bending fracture mechanics test is combined with digital image correlation (DIC) measurements of displacement fields and finite element model updating. The elastic parameters of an orthotropic composite and the parameters for a cohesive zone fracture model are determined from one transverse crack growth experiment. The fracture toughness for tangential-longitudinal (TL) cracks was lower than expected, as explained by local peeling fracture of the wood cell wall.