gebhart/patrepeval huggingface dataset:
Organometallic Complexes of Tantalum That Contain the Triamidoamine Ligand, [(Me3SiNCH2CH2)3N]3-, Including an Ethylidene Complex Formed via a Phosphine-Catalyzed Rearrangement of an Ethylene Complex (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic Complexes of Tantalum That Contain the Triamidoamine Ligand, [(Me3SiNCH2CH2)3N]3-, Including an Ethylidene Complex Formed via a Phosphine-Catalyzed Rearrangement of an Ethylene ComplexJoel S. Freundlich, Richard R. Schrock, Christopher C. Cummins, and William M. DavisCite this: J. Am. Chem. Soc. 1994, 116, 14, 6476–6477Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00093a075https://doi.org/10.1021/ja00093a075research-articleACS PublicationsRequest reuse permissionsArticle Views601Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Vanitas (2020)

Journal Article Vanitas Get access Kim Roberts Kim Roberts Email: kimroberts.dc@gmail.com Search for other works by this author on: Oxford Academic Google Scholar ISLE: Interdisciplinary Studies in Literature and Environment, Volume 29, Issue 4, Winter 2022, Pages 1334–1337, https://doi.org/10.1093/isle/isaa147 Published: 15 September 2020 Article history Received: 15 July 2020 Editorial decision: 17 August 2020 Accepted: 28 August 2020 Published: 15 September 2020
ECOTOXICOLOGY AND SPATIAL MODELING IN POPULATION DYNAMICS: AN ILLUSTRATION WITH BROWN TROUT (2003)

We developed a multiregion matrix population model to explore how the demography of a hypothetical brown trout population living in a river network varies in response to different spatial scenarios of cadmium contamination. Age structure, spatial distribution, and demographic and migration processes are taken into account in the model. Chronic or acute cadmium concentrations affect the demographic parameters at the scale of the river range. The outputs of the model constitute population-level end points (the asymptotic population growth rate, the stable age structure, and the asymptotic spatial distribution) that allow comparing the different spatial scenarios of contamination regarding the demographic response at the scale of the whole river network. An analysis of the sensitivity of these end points to lower order parameters enables us to link the local effects of cadmium to the global demographic behavior of the brown trout population. Such a link is of broad interest in the point of view of ecotoxicological management.
Agrin in Alzheimer’s disease: Altered solubility and abnormal distribution within microvasculature and brain parenchyma (1999)

Agrin is a heparan sulfate proteoglycan that is widely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous system. Agrin induces the differentiation of nerve-muscle synapses, but its function in either normal or diseased brains is not known. Alzheimer's disease (AD) is characterized by loss of synapses, changes in microvascular architecture, and formation of neurofibrillary tangles and senile plaques. Here we have asked whether AD causes changes in the distribution and biochemical properties of agrin. Immunostaining of normal, aged human central nervous system revealed that agrin is expressed in neurons in multiple brain areas. Robust agrin immunoreactivity was observed uniformly in the microvascular basal lamina. In AD brains, agrin is highly concentrated in both diffuse and neuritic plaques as well as neurofibrillary tangles; neuronal expression of agrin also was observed. Furthermore, patients with AD had microvascular alterations characterized by thinning and fragmentation of the basal lamina. Detergent extraction and Western blotting showed that virtually all the agrin in normal brain is soluble in 1% SDS. In contrast, a large fraction of the agrin in AD brains is insoluble under these conditions, suggesting that it is tightly associated with beta-amyloid. Together, these data indicate that the agrin abnormalities observed in AD are closely linked to beta-amyloid deposition. These observations suggest that altered agrin expression in the microvasculature and the brain parenchyma contribute to the pathogenesis of AD.
Size-Dependent Kinetics of Hydriding and Dehydriding of Pd Nanoparticles (2010)

Using a new indirect nanoplasmonic sensing method with subsecond resolution, we have studied hydriding and dehydriding kinetics of Pd nanoparticles in the size range 1.8-5.4 nm. Strong particle-size effects are observed. The scaling of the hydriding and dehydriding time scales satisfies power and power-exponential laws. The former (with an exponent of 2.9) is in perfect agreement with Monte Carlo simulations of diffusion-controlled hydriding kinetics. The latter is explained by the effect of surface tension on hydrogen desorption from the surface layer. The approach is generalizable to other reactant-nanoparticle systems.
Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo-Drusen? (2021)

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is caused by dominant-acting mutations in the gene colony-stimulating factor 1 receptor (<i>CSF1R</i>). It is an ultra-rare leukoencephalopathy that involves demyelination of white matter and early-onset dementia. It has been well validated that mutations in the kinase region of the gene cause decreased signaling of the receptor via its two cognate ligands interleukin-34 (IL-34) and colony-stimulating factor-1 (CSF-1). In this article, we report a thorough analysis of retinal integrity in a 48-year-old genetically diagnosed ALSP patient. We show that although the optic nerve, optic chiasm, and optic tracts are relatively preserved, the patient has visual field deficits likely due to optic radiation and/or cortical atrophy. Intriguingly, we report the appearance of inner retinal vascular leakage and the appearance of reticular pseudo-drusen (RPD)-like deposits. We propose that the early stages of RPD accumulation may be associated with an attenuated CSF-1 receptor signaling axis. <b>[<i>Ophthalmic Surg Lasers Imaging Retina.</i> 2021;52:666-671.]</b>.
Thermoelectric Materials and Devices (2016)

Thermal energy harvesting is predicted to become a global, billion-pound market by 2020. This book provides a current perspective of recent developments and trends within thermoelectric materials and devices for power energy harvesting applications. The book highlights the potential of thermoelectrics in the context of a low carbon energy economy, and features in-depth coverage of a range of different fabrication methods for thermoelectric materials including electrodeposition. Topics covered include layered and pseudo-layered materials, thermoelectric oxides, nano- and micro-fabrication techniques, high-throughput thermoelectric measurement techniques and power mining. This book is ideal for researchers and industrialists in materials science.
Complement factor H Y402H polymorphism and characteristics of exudative age‐related macular degeneration lesions (2007)

We detected no clear impact of the CFH Y402H polymorphism on recent exudative AMD lesion characteristics. Although the complement cascade is implicated in CNV formation and scarring processes in the retina, the Y402H polymorphism appears relatively neutral in these functions.
Electrically shielded dielectric elastomer actuators for the study of the mechanical perturbation of cardiomyocytes (2016)

We present the development of a mechanically active bioreactor. Using dielectric elastomer actuators (DEA), we are able to mechanically perturb cell cultures in a controlled environment. With tailored pre-strain and compliant electrodes, it is possible to digitally control the strain state of the cell culture substrate and generate tensile strain exceeding 20%. This bioreactor enables new types of studies of cytomechanics. Specifically, we will use the bioreactor to study cellular mechanisms of cardiac arrhythmias that are related to mechanoelectrical feedback. DEAs require high electric fields to generate physiologically relevant strain levels of 10%. Typically, potentials up to 5 kV are applied to electrodes that are located a few tens of microns from the cells. Resulting electrical fields may adversely affect cell physiology and mask the mechanosensitive response under study. To circumvent this problem, we present a stacked DEA design where the HV-electrode is embedded between grounded electrodes. This design practically eliminates the cells’ exposure to fringe fields. Compared to a two-electrode configuration, it is shown that stray fields can be suppressed by six orders of magnitude. Tests on cardiomyocytes indicate that this layout is sufficient to prevent unwanted electrical triggering of the action potential. The device presented demonstrates the ability to combine electrically sensitive cells with mechanically active DEA bioreactors.
Adversarial examples influence human visual perception (2019)

Computer vision models are vulnerable to adversarial examples: small changes to images that cause models to make mistakes. Adversarial examples often transfer from one model to another, making it possible to attack models that an attacker has no access to. This raises the question of whether adversarial examples similarly transfer to humans. Clearly, humans are prone to many cognitive biases and optical illusions, but these generally do not resemble small perturbations, nor are they generated by optimization of a machine learning loss function. Thus, adversarial examples has been widely assumed – in the absence of experimental evidence – to not influence human perception. A rigorous investigation of the above question creates an opportunity both for machine learning and neuroscience. If we knew that the human brain could resist certain classes of adversarial examples, this would provide an existence proof for a similar mechanism in machine learning security. On the other hand, if we knew that the brain could be fooled by adversarial examples, this phenomenon could lead to a better understanding of brain function. Here, we investigate this question by leveraging three ideas from machine learning, neuroscience, and psychophysics[1]. First, we use black box adversarial example construction techniques to generate adversarial examples. Second, we adapt machine learning models to mimic the initial visual processing of humans. Third, we evaluate classification decisions of human observers in a time-limited setting to limit the brain’s utilization of recurrent and top-down processing pathways[2]. We find that adversarial examples that strongly transfer across computer vision models influence the classifications made by time-limited human observers. [1] A version of this work is accepted, but not yet presented, as a conference paper at NIPS 2018. [2] M. Potter et al. Detecting meaning in rsvp at 13 ms per picture. Attention, Perception, Psychophysics, 76(2):270–279, 2014.
Software-Assisted Analysis During Ocular Health Screening (2012)

Software-assisted screening permits thorough and efficient evaluation of ocular health during an ocular screening event.
Front Cover: Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 (ChemMedChem 17/2017) (2017)

The front cover picture shows the crystal structure of MK-8876 bound to the hepatitis C virus (HCV) NS5B protein. The biaryl linkage at the 5-position of the benzofuran acts as a bridge between the Palm I and Palm II binding sites, enabling MK-8876 to interact with both sites simultaneously. MK-8876 shows broad potency against a wide range of HCV genotypes and maintains that potency against clinically relevant mutants. More information can be found in the Full Paper by Casey C. McComas et al. on page 1436 in Issue 17, 2017 (DOI: 10.1002/cmdc.201700228).
Magnetic state ofLa1.36Sr1.64Mn2O7probed by magnetic force microscopy (2008)

We have investigated the ferromagnetic (FM) domain structure of a single-crystal bilayered manganite ${\mathrm{La}}_{2\ensuremath{-}2x}{\mathrm{Sr}}_{1+2x}{\mathrm{Mn}}_{2}{\mathrm{O}}_{7}$ $(x=0.32)$ by using low-temperature magnetic force microscopy. We observed that below $65\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, the FM domains form stable treelike patterns with out-of-plane magnetization. With increasing temperature, the FM domain patterns gradually change in the form of domain wall motion. Above $80\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, the FM domain patterns change more and more with each temperature step. The magnetization changes from the out-of-plane to an in-plane direction around $88\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. The in-plane FM domains almost completely disappear near the Curie temperature of this sample $({T}_{C}\ensuremath{\approx}110\phantom{\rule{0.3em}{0ex}}\mathrm{K})$, where the resistivity exhibits a sharp increase. We also observed large changes in the magnetic structures upon thermal cycling. We concluded that the formation of FM domains at low temperatures $(T&lt;80\phantom{\rule{0.3em}{0ex}}\mathrm{K})$ is determined by the energy associated with surface magnetic free poles and domain walls. At high temperatures $(80\phantom{\rule{0.3em}{0ex}}\mathrm{K}&lt;T&lt;{T}_{C})$, the two-dimensional FM fluctuations in the basal plane may also play an important role in forming the domain structures. The evolution of the FM domain patterns with temperature coincides with the change in resistivity.
Detection of Pathogenic Bacteria by Using Zinc Finger Protein Fused with Firefly Luciferase (2012)

We constructed a novel bacterial genome detection system using zinc finger protein (ZF) fused with firefly luciferase (ZF-luciferase). Taking advantage of the direct recognition of double-stranded DNA (dsDNA) by ZF, we previously constructed bacterial genome detection systems that did not require dehybridization processes. To detect polymerase chain reaction (PCR) products rapidly and with a high sensitivity, we constructed two kinds of ZF-luciferase, Sp1-fused luciferase (Sp1-luciferase), and Zif268-fused luciferase (Zif268-luciferase). ZF-luciferase not only maintains luciferase activity but also shows dsDNA-binding ability and specificity. Furthermore, we succeeded in the detection of 10 copies of the genome of Legionella pneumophila and Escherichia coli O157. ZF-luciferase would be a useful tool for highly sensitive detection of pathogenic bacterial genome.
Data from T-cell Responses to <i>TP53</i> “Hotspot” Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Patients and Methods:&lt;/b&gt; Tumor-infiltrating lymphocytes (TIL) were expanded from resected ovarian cancer metastases, which were analyzed by whole-exome and transcriptome sequencing to identify autologous somatic mutations. All mutated neoepitopes, independent of prediction algorithms, were expressed in autologous antigen-presenting cells and then cocultured with TIL fragment cultures. Secretion of IFNγ or upregulation of 41BB indicated a T-cell response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Seven women with metastatic ovarian cancer were evaluated, and 5 patients had clear, dominant T-cell responses to mutated neoantigens, which were corroborated by comparison with the wild-type sequence, identification of the minimal epitope, human leukocyte antigen (HLA) restriction element(s), and neoantigen-specific T-cell receptor(s). Mutated neoantigens were restricted by HLA-B, -C, -DP, -DQ, and/or -DR alleles and appeared to principally arise from random, somatic mutations unique to each patient. We established that &lt;i&gt;TP53&lt;/i&gt; “hotspot” mutations (c.659A&gt;G; p.Y220C and c.733G&gt;A; p.G245S) expressed by two different patients' tumors were both immunogenic in the context of HLA-DRB3*02:02.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Mutation-reactive T cells infiltrated ovarian cancer metastases at sufficient frequencies to warrant their investigation as adoptive cell therapy. In addition, transfer of &lt;i&gt;TP53&lt;/i&gt; “hotspot” mutation-reactive T-cell receptors into peripheral blood T cells could be evaluated as a gene therapy for a diverse range of tumor histologies. &lt;i&gt;Clin Cancer Res; 24(22); 5562–73. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by McNeish, p. 5493&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
The assessment of enriched apoplastic extracts using proteomic approaches (2003)

Summary In plant tissues the extracellular environment or apoplast, incorporating the cell wall, is a highly dynamic compartment with a role in many important plant processes including defence, development, signalling and assimilate partitioning. Soluble apoplast proteins from Arabidopsis thaliana, Triticum aestivum and Oryza sativa were separated by two‐dimensional electrophoresis. The molecular weights and isoelectric points for the dominant proteins were established prior to excision, sequencing and identification by matrix‐assisted laser‐desorption ionisation time of flight mass spectrometry (MALDI ‐ TOF MS). From the selected spots, 23 proteins from O. sativa and 25 proteins from A. thaliana were sequenced, of which nine identifications were made in O. sativa (39%) and 14 in A. thaliana (56%). This analysis revealed that: (i) patterns of proteins revealed by two‐dimensional electrophoresis were different for each species indicating that speciation could occur at the level of the apoplast, (ii) of the proteins characterised many belonged to diverse families reflecting the multiple functions of the apoplast and (iii), a large number of the apoplast proteins could not be identified indicating that the majority of extracellular proteins are yet to be assigned. The principal proteins identified in the aqueous matrix of the apoplast were involved in defence, i.e. germin‐like proteins or glucanases, and cell expansion, i.e. β‐D‐glucan glucohydrolases. This study has demonstrated that proteomic analysis can be used to resolve the apoplastic protein complement and to identify adaptive changes induced by environmental effectors.
Mutual coupling suppression in an array of 2-layer self-excited EBG resonator antennas (2015)

The paper presents a new small planar antenna and describes how to effectively employ it in an electrically dense array. The antenna is composed of 2-layer electromagnetic bandgap (EBG) cells and is a thin version of the formerly introduced thick self-excited EBG resonator antenna. The effect of mutual coupling on the input impedance of the adjacent elements in a sample array is demonstrated, and a technique to suppress this effect, using a high impedance (HI) surface, is applied. Simulation results show that the application of proposed high-performance elements and the HI surface maintains the balance in the feed network and the symmetry in the broadside pattern, even at the presence of high-dielectric substrates.
Spectral Distortions in Metal-Enhanced Fluorescence: Experimental Evidence for Ultra-Fast and Slow Transitions (2020)

Metal-enhanced fluorescence (MEF) has become an increasingly important technology in recent years, with thorough research addressing the fundamentals of MEF. In many studies, spectral distortion is observed in the enhanced spectra as compared to free-space fluorescence emission profiles. Despite this observation, very little experimentation has hitherto been undertaken to investigate the mechanistic underpinnings of spectral distortion in MEF. Herein, we investigate MEF spectral distortion using Rose Bengal and fluorescein on silver nanoparticle substrates, subsequently isolating the coupled fluorescence spectrum for a deeper understanding of the spectral modifications. Clear experimental evidence for bathochromic distortion is reported. Remarkably, we also report hypsochromic distortion in one of the first experimental observations of plasmonic coupling to high-energy excited states. Additionally, the coupled fluorescence spectra from other published literature have also been both extracted and examined, and the subsequent spectral distortions are reported here. The previously asserted theory of radiative decay rate modification for spectral distortion is discussed in the context of both plasmonic properties as well as fluorophore photophysical characteristics including lifetime and quantum yield. The dual enhancement mechanism of MEF is also explored in the context of spectral distortion. The results and discussion reported herein subsequently provide one of the first comprehensive examinations of spectral distortion in MEF to date.
Synthesis and Quantitative Structure−Activity Relationship of Hydrazones ofN-Amino-N‘-hydroxyguanidine as Electron Acceptors for Xanthine Oxidase (2004)

A series of new N-hydroxyguanidines were synthesized and tested for electron acceptor activity on bovine milk xanthine oxidase using xanthine as reducing substrate. Manual inspection of the structure-activity data revealed that molecules containing nitro groups ("set A") show a different structure-activity relationship pattern compared to non-nitro compounds ("set B"). Accordingly separate QSAR models were built and validated for the two sets. Substantial differences were found in properties governing acceptor activity for the models, the only common property being sterical access to the imino nitrogen atom of the hydroxyguanidinimines. For set A molecules the presence of a nitro substituent at a certain distance range from the hydroxuguanidino group was most important. In addition, the presence of a nitro group in the ortho position interacting with NH(2) of the hydroxyguanidino group, and the mutual geometry of the phenyl ring, hydroxyguanidine, and imine groups was important for this set. By contrast, for set B molecules the acceptor activity was most influenced by the geometry of methoxy groups and the size and geometry of meta and para substituents of the phenyl ring.