gebhart/patrepeval huggingface dataset:
Photocatalytic alcohol dehydrogenation using ammonium heptamolybdate (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocatalytic alcohol dehydrogenation using ammonium heptamolybdateMichael D. Ward, James F. Brazdil, and Robert K. GrasselliCite this: J. Phys. Chem. 1984, 88, 19, 4210–4213Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/j150663a004https://doi.org/10.1021/j150663a004research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
510. Treating Epithelial and Metastatic Malignancies with Glycoform-Specific Chimeric Antigen Receptors (2016)

Cancer-specific glycosylation deficiencies generating Tn or sTn O-linked glycans are found in >80% of the most lethal cancers (lung, prostate, breast, colon, ovary, pancreas). These hypoglycosylated cancer glycoantigens decrease cell-cell interactions and increase the mobility and metastatic potential of tumor cells. We developed a CAR specific to the Tn/sTn antigen of the oncogene Mucin-1 (MUC1), which is highly upregulated in many epithelial cancers and is heavily O- and N-glycosylated. Our CAR uses the scFv sequence derived from the 5E5 mAb and the endodomains of CD3zeta and 4-1BB that promote T cell activation and co-stimulation, respectively. We have shown that the 5E5 mAb and the 5E5 CAR are specific to the cancer-specific glycoform of MUC1 but not normal MUC1 through in vitro binding and cytokine assays and that the 5E5 CAR is non-reactive to normal human primary cells. We demonstrated that the 5E5 CAR T cells are responsive to ovarian, breast, lung, pancreatic, and leukemia cancers and developed NSG mouse xenograft models using Jurkat leukemia cell line and Hs766T metastatic pancreatic cell line that show rapid clearance of established tumors by 5E5 CAR T cells and prolonged survival of tumor-bearing mice. Restoring normal glycosylation in Jurkat leukemia cells abolishes the expression of the hypoglycosylated form of Muc1 and also prevents 5E5 CAR T cell cytotoxicity, further highlighting the specificity of the 5E5 CAR for the cancer-specific glycoform of MUC1. Infusion of human MUC1-transgenic mice with murine 5E5 CAR T cells showed an exquisite safety profile, while infusion of normal glycoform MUC1-specific murine CAR T cells (HMFG1 CAR, a previously described MUC1-specific CAR) demonstrate extreme safety concerns. These results demonstrate that targeting the cancer-specific glycoform of MUC1 provides a safe, yet potent cancer-specific immunotherapy for treating most epithelial malignancies and holds the potential to eradicate metastatic disease.
Figure S4 from Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection (2023)

&lt;p&gt;Targeting of MB with ABYB7-H3 does not increase MB attachment to MS1WT cells.&lt;/p&gt;
Some results of the MIRAS-SMOS demonstrator campaigns (2007)

In this paper, some results of the MIRAS-SMOS demonstrator campaigns are presented. The follow two campaigns were held: an image validation campaign at IRTA side and a flight demonstrator campaign at Finland. The ultimate objective of the airborne demonstrator is to demonstrate its imaging capabilities by applying improved calibration and inversion algorithms to natural low-contrast targets.
Challenges in material recycling for postwar reconstruction (2022)

Besides the fact that concrete recycling allows to avoid landfills disposal and contributes to a closed-cycle economy, such option may be very much in demand in war struck regions such as Ukraine, which after the end of the war, are faced with the problem of rebuilding and reconstructing. Beyond this emergency, even in peacetime extensive parts of the building stock will sooner or later need to be replaced and concrete recycling is called to play an increasing role there. However, depending on the technology and degree to which aggregates are recycled, concrete may be characterized by poor workability, reduced mechanical properties, increased shrinkage and reduced durability. This deterioration in the properties of recycled concrete is usually attributed to the characteristics of the old cement mortar remaining on the surface of the recycled aggregates, which is best considered as an additional volume of hardened cement paste with fine aggregate and additional porosity. This article attempts to underline how such key concepts help frame the current state of knowledge about concrete recycling, understand the implications of existing regulations, in order to define pragmatic and efficient routes for broadening the use of concrete recycling in war struck regions, with specific examples regarding Ukraine.
Molecular Dynamics of a Liquid Crystalline Polymer Studied by Two-Dimensional Fourier Transform and CW ESR (1996)

Two-dimensional Fourier transform (2D-FT) and CW-ESR experiments at X-band frequencies were performed over a broad range of temperatures covering the solid and melt states of a liquid crystalline (LC) polymer. The CW-ESR experiments were analyzed by conventional motional models. The nematic phase was macroscopically aligned in the dc magnetic field, whereas the solid state showed microscopic order but macroscopic disorder (MOMD). An end-label on the polymer showed smaller ordering and larger reorientational rates than that of the cholestane (CSL) spin probe dissolved in the same polymer, since the former can reorient by local internal chain modes. It was demonstrated that the 2D-FT-ESR experiments provide greatly enhanced resolution to the ordering and dynamics of the end-label, especially when performed as 2D-ELDOR (electron−electron double resonance) experiments as a function of mixing time. The conventional model of Brownian reorientation in an orienting potential was unsuccessful in interpreting these results. Instead the model of a slowly relaxing local structure (SRLS), which enables differentiation between the local internal modes experienced by the end-label and the collective reorganization of the polymer molecules around the end label, yielded much improved fits to the experiments in the nematic phase. These nonlinear least squares fits showed that the polymer "cage" relaxes more than 2 orders of magnitude slower than the local end-chain modes, and there is a moderate orientational potential coupling the local end-chain motion to the "cage" with axial and nonaxial local order parameters of about 0.14 and 0.29 at 100 °C. In the solid state the 2D-ELDOR spectra were fitted to the MOMD model, which is a limiting case of the SRLS model when the cage relaxation becomes very slow.
AIDS vaccines: concepts and first trials. (1989)

Two categories of obstacles impede the development of an AIDS vaccine. Virological obstacles are due to lentiviruses, to which HIV and SIV belong, having developed strategies to escape the immune responses of infected hosts and establish persistent infection. These strategies are based on two mechanisms: latency corresponding to restriction of viral gene expression that renders the virus antigenically invisible, and variability, the consequences of which are antigenic shift and permanent adaptation to selective pressures. Immunological obstacles are linked to a central unanswered question: is the global effect of the immune response against HIV beneficial or deleterious to the host and, if beneficial, is it able to resist the virally induced immunosuppression? These obstacles are difficult to overcome theoretically and empirical trials are necessary; live attenuated or recombinant vaccines, inactivated vaccines, subunit vaccines, anti-idiotypes, and synthetic and chimeric vaccines are currently being tested in animals or in humans. At present, promising results have been obtained with inactivated virus vaccines with the use of macaque monkeys infected by SIV as a model.
Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation (2018)

It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification. Herein, we present the concept of bioactive molecular networking to find candidate active molecules directly from fractionated bioactive extracts. By employing tandem mass spectrometry, it is possible to accelerate the dereplication of molecules using molecular networking prior to subsequent isolation of the compounds, and it is also possible to expose potentially bioactive molecules using bioactivity score prediction. Indeed, bioactivity score prediction can be calculated with the relative abundance of a molecule in fractions and the bioactivity level of each fraction. For that reason, we have developed a bioinformatic workflow able to map bioactivity score in molecular networks and applied it for discovery of antiviral compounds from a previously investigated extract of Euphorbia dendroides where the bioactive candidate molecules were not discovered following a classical bioassay-guided fractionation procedure. It can be expected that this approach will be implemented as a systematic strategy, not only in current and future bioactive lead discovery from natural extract collections but also for the reinvestigation of the untapped reservoir of bioactive analogues in previous bioassay-guided fractionation efforts.
High Voltage Complementary Epi Free LDMOS Module with 70 V PLDMOS for a 0.25 &#956;m SiGe:C BiCMOS Platform (2008)

We demonstrate the integration of a low-cost, high-voltage complementary LDMOS module with BVdss of -71V and 83V for the PLDMOS and the NLDMOS, respectively, into an advanced industrial 0.25 mum SiGe:C BICMOS process. The essential deep N-well for the high voltage PLDMOS is formed by a single 6MeV P implantation step. BVdss*ft of the NLDMOS accomplishes record values > 900 VGHz.
Robust feedforward control system considering sudden disturbance for optical disk recording system (2006)

Abstract This paper proposes a new robust feedforward tracking servo system for optical disk recording systems in the case of a sudden disturbance for the optical disk recording system. In optical recording systems, the tracking servo system must suppress tracking error below its tolerance. This paper designs the robust feedback control system by using the coprime factorization and disturbance observer. The proposed robust feedback control system suppresses the sudden disturbance caused by walking and running. The detecting signal of optical disk recording systems is only a tracking error. Hence, the feedforward controller of the proposed tracking control system is constructed based on both Zero Phase Error Tracking (ZPET) control theory and prediction of tracking error. The experimental results point out that the proposed tracking servo system has a quick and precise tracking response and keeps the residual tracking error below its tolerance. © 2006 Wiley Periodicals, Inc. Electr Eng Jpn, 156(4): 60– 68, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20257
A SiC-Based Matrix Converter Topology for Inductive Power Transfer System (2014)

Typical inductive power transfer (IPT) systems employ two power conversion stages to generate a high-frequency primary current from low-frequency utility supply. This paper proposes a matrix-converter-based IPT system, which employs high-speed SiC devices to facilitate the generation of high-frequency current through a single power conversion stage. The proposed matrix converter topology transforms a three-phase low-frequency voltage system to a high-frequency single-phase voltage, which, in turn, powers a series compensated IPT system. A comprehensive mathematical model is developed and power losses are evaluated to investigate the efficiency of the proposed converter topology. Theoretical results are presented with simulations, which are performed in MATLAB/Simulink, in comparison to a conventional two-stage converter. Experimental evident of a prototype IPT system is also presented to demonstrate the applicability of the proposed concept.
O4‐04‐01: Characterization of a humanized amyloid beta oligomer monoclonal antibody (5E3) under preclinical development for passive immunotherapy of Alzheimer's disease (2015)

Soluble Amyloid βeta oligomers (AβOs) trigger a cascade of toxic signaling in neurons that disrupt neuronal communication, behavior dysfunction and memory loss in Alzheimer's disease (AD). A murine monoclonal antibody (m5E3) has been developed, with demonstrated specificity and selectivity that targets soluble AβOs in vivo and treatment reduced levels in CSF and brain homogenates in Tg2576 and APP/PS1 treated mice. Affinity has been retained across humanized isotype variants and reduced effector functionality has been incorporated by design. Preclinical evaluation is described including a number of physicochemical attributes and pharmacokinetic properties of purified humanized 5E3 in mice. Expression vectors encoding for the IgG1, IgG2 and IgG4 variants were used to transfect CHO K1SV by electroporation or Lipofectiamine®. Immunoreactivity of purified antibodies was characterized by ELISA and immunoblotting, and affinity confirmed against cyclic-SNK (cSNK) and synthetic AβO epitope (Octet analysis and Biacore™ 300). Biodistribution and pharmacokinetic properties were determined in ApoE4 mice using unlabelled and labeled mAbs. Purified isotype variants retained similar affinity and selectivity towards the cSNK epitope and synthetic Aβ42 oligomers. The naturally occurring target recognized by m5E3 in human AD biospecimens was also recognized by all humanized variants. The biodistribution of fluorescent and radio-labelled m5E3 and humanized mAbs was assessed following i.p. injection in mice. The distribution of antibodies was assessed to determine penetration in the CNS and clearance profile in the absence of target (i.e. soluble AβOs). In order to meet the manufacture requirements and advance selection, stable cell lines have been established for each isotype to support manufacturing at commercially relevant levels. The humanization of m5E3 to various isotypic frameworks was completed and affinity to the conformationally constrained cSNK epitope and the selective target of AβO was retained. Systemic administration (i.p.) of humanized variants was assessed to determine penetration across the BBB and clearance. Together, these data provide reassurance towards preclinical evaluation for lead candidate selection and IND enabling studies.
Enzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substances (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substancesChi Huey Wong and George M. WhitesidesCite this: J. Am. Chem. Soc. 1983, 105, 15, 5012–5014Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00353a026https://doi.org/10.1021/ja00353a026research-articleACS PublicationsRequest reuse permissionsArticle Views543Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glucose tolerance in Polynesia: Population‐based surveys in Rarotonga and Niue (1986)

Glucose tolerance and the prevalence of impaired glucose tolerance (IGT) and diabetes in the Polynesian populations of Rarotonga and Niue were studied in 1980. Both Rarotongans and Niueans have been considerably influenced by sociocultural modernization and (in the case of Rarotonga) tourism. In both populations, the prevalence of abnormal glucose tolerance exceeded 10% in men and 15% in women. There was an association between glucose tolerance and age and obesity in both sexes, but not between glucose tolerance and physical activity. Glucose tolerance did not differ between Rarotongans and Niueans after allowing for differences in age and obesity. Comparisons between normal subjects, those with impaired glucose tolerance (IGT) and diabetic subjects with respect to factors that are traditionally associated with glucose intolerance provided some support for IGT as a truly intermediate diagnostic category of glucose tolerance.
A Stable Upstream Stem-loop Structure Enhances Selection of the First 5&prime;-ORF-AUG as a Main Start Codon for Translation Initiation of Human ACAT1 mRNA (2004)

Human ACAT 1 cDNA K1 was first cloned and functionally expressed in 1993. There are two adjacent in-frame AUG codons, AUG(1397-1399) and AUG(1415-1417), at 5'-terminus of the open reading frame (ORF, nt 1397-3049) of human ACAT1 mRNA corresponding to cDNA K1. In current work, these two adjacent inframe AUGs at 5'-terminus of the predicted ORF (5'-ORF-AUGs) as start codons for translation initiation of human ACAT1 mRNA were characterized in detail. Codon mutations indicated that both of these two adjacent 5'-ORF-AUGs can be selected as start codons but the first 5'-ORF-AUG(1397-1399) is a main start codon consistent with that of the predicted ORF of human ACAT1 mRNA. Further deletion and mutation analyses demonstrated that a stable upstream stem-loop structure enhanced the selection of the first 5'-ORF-AUG(1397 -1399) as a main start codon, in addition to upstream nucleotide A in the -3 position, which is a key site of Kozak sequence. In addition, result of ACAT1 enzymatic activity assay showed no obvious difference between these two ACAT1 proteins respectively initiated from the two adjacent 5'-ORF-AUGs. This work showed that a stable upstream stem-loop structure could modulate the start codon selection during translation initiation of mRNAs that contain adjacent multi-5'-ORF-AUGs.
A clinical trial of long-acting local anesthetics for periodontal surgery. (1990)

The efficacy of long-acting local anesthetics for anesthesia during periodontal surgery and for analgesia during the immediate postoperative period was evaluated. The rationale for using long-acting local anesthetics such as etidocaine and bupivacaine is that they can provide surgical anesthesia and, because of their long duration, prevent discomfort that may occur for 4-6 hours postoperatively. Two clinical trials were performed. The first enrolled patients requiring bilateral periodontal surgery. Using a matched pair design and double-blind randomized study conditions, 2% lidocaine 1/100,000 epinephrine was compared with 1.5% etidocaine 1/200,000 epinephrine for periodontal surgery. The time until complete recovery and the time until pain onset were found to be longer for the etidocaine surgeries. Postoperative pain appeared more severe, and the need for oral analgesics was greater for the lidocaine surgeries. Surgeons' rating of surgical bleeding was significantly greater for the etidocaine procedures. When matched bilateral surgeries were not available, a second double-blind randomized parallel trial was performed that compared 1.5% etidocaine 1/200,000 epinephrine to 0.5% bupivacaine 1/200,000 epinephrine. No significant differences were seen in the quality of anesthesia, degree of bleeding, or postoperative pain between these two long-acting anesthetics.
Technical Note: Rod phantom analysis for comparison of PET detector sampling and reconstruction methods (2016)

Using the proposed scanner performance methodology, it was shown that smaller detector elements and a larger number of image voxels require higher count density in order to demonstrate improved image quality and quantitation. In a body imaging scenario under typical clinical conditions, the potential advantages of the design must overcome increases in noise due to lower count density.
A MULTIPLE INTELLIGENT AGENT SYSTEM FOR CREDIT RISK PREDICTION VIA AN OPTIMIZATION OF LOCALIZED GENERALIZATION ERROR WITH DIVERSITY (2007)

公司破产每年在损失花费了十亿美元到银行。因此承认风险预言是一个银行的贷款赞同决定过程的关键部分。为信用风险预言的传统的金融模型为 describingtoday 在金融健康和一个公司的潜在的破产之间的复杂关系不再是足够的。Inthis 工作，一个多重分类器系统(在一个多重聪明的代理人系统嵌入) 被建议预言一个公司的金融健康。在我们的模型，每个单个代理人(分类器) 基于公司的仅仅偏爱的信息在信用风险的可能性上做预言。每代理人是一位专家，但是限制了知识(由特征代表了) 关于公司。所有代理人的决定一起被联合形成最后的信用风险预言。实验证明我们的模型用 benchmarking Compustat 美国公司数据集超过另外的存在方法。
Training toddlers seated on mobile robots to drive indoors amidst obstacles (2010)

The goal of this research is to train children seated on mobile robots to purposefully and safely drive indoors. Our previous studies show that in about six weeks of training, infants can learn to drive directly to a goal using conventional joysticks. However, they are unable to acquire the advanced skill to avoid obstacles while driving. This limits mobility impaired children from exploring their home environment safely, which in turn impacts their cognitive and social developments in the important early years. In this paper, we describe results where toddlers are trained to drive a robot within an obstacle course. Using algorithms based on artificial potential fields to avoid obstacles, we create force field on the joystick that trains them to navigate while avoiding obstacles. In this `assist-as-needed' approach, if the child steers the mobile robot outside a force tunnel centered around the desired direction, the driver experiences a bias force on the hand. The results suggest that force-feedback joystick results in faster learning than with a conventional joystick.
Co-lasing in an electrically tunable erbium-doped fiber laser (1992)

We demonstrate simultaneous wavelength operation (co-lasing) of an erbium-doped fiber ring laser with independent tunability of each wavelength over 35 nm between 1528 and 1563 nm. We study two different configurations and also investigate use of aluminum versus germanium codoped gain modules in the ring. We find that the aluminum codoped gain module has superior tunability.