gebhart/patrepeval huggingface dataset:
Germanium Fluoride Nanocages as Optically Transparent n-Type Materials and Their Endohedral Metallofullerene Derivatives (2019)

Carbon- and silicon-based n-type materials tend to suffer from instability of the corresponding radical anions. With DFT calculations, we explore a promising route to overcome such challenges with molecular nanocages which utilize the heavier element Ge. The addition of fluorine substituents creates large electron affinities in the range 2.5-5.5 eV and HOMO-LUMO gaps between 1.6 and 3.2 eV. The LUMOs envelop the surfaces of these structures, suggesting extensive delocalization of injected electrons, analogous to fullerene acceptors. Moreover, these Ge <sub>n</sub>F <sub>n</sub> inorganic cages are found to be transparent in the UV-visible region as probed with their excited states. Their capacitance, linear polarizabilities, and dielectric constants are computed and found to be on the same order of magnitude as saturated oligomers and some extended π-organics (azobenzenes). Furthermore, we explore fullerene-type endohedral isomers, i.e., cages with internal substituents or guest atoms, and find them to be more stable than the parent exohedral isomers by up to -206.45 kcal mol<sup>-1</sup>. We also consider the addition of Li, He, Cs, and Bi, to probe the utility of the exo/ endo cages as host-guest systems. The endohedral He/Li@F<sub>8</sub>@Ge<sub>60</sub>F<sub>52</sub> cages are significantly more stable than their parent exohedral isomers He/Li@Ge<sub>60</sub>F<sub>52</sub> by -182.46 and -49.22 kcal mol<sup>-1</sup>, respectively. The energy of formation of endohedral He@F<sub>8</sub>@Ge<sub>60</sub>F<sub>52</sub> is exothermic by -10.4 kcal mol<sup>-1</sup>, while Cs and Bi guests are too large to be accommodated but are stable in the exohedral parent cages. Conceivable applications of these materials include n-type semiconductors and transparent electrodes, with potential for novel energy storage modalities.
Scalable integration of long-lived quantum memories into a photonic\n circuit (2014)

We demonstrate a photonic circuit with integrated long-lived quantum\nmemories. Pre-selected quantum nodes - diamond micro-waveguides containing\nsingle, stable, and negatively charged nitrogen vacancy centers - are\ndeterministically integrated into low-loss silicon nitride waveguides. Each\nquantum memory node efficiently couples into the single-mode waveguide (&gt; 1\nMcps collected into the waveguide) and exhibits long spin coherence times of up\nto 120 {\\mu}s. Our system facilitates the assembly of multiple quantum memories\ninto a photonic integrated circuit with near unity yield, paving the way\ntowards scalable quantum information processing.\n
Modulation of milk polar lipids powder composition and functionalities using lipases and phospholipases (2012)

Milk polar lipids have attracted attention over the last decade due to their interesting nutritional properties and high content in sphingolipids which are implicated in cell metabolism. Milk polar lipids are currently available under the form of commercial powders derived from buttermilk of variable purity. The composition of these powders could be tailored using lipases or phospholipases to modulate their polar lipids profile, increase their purity in sphingolipids and possibly enhance their bioactivity. The objective of this work was thus to assess the potential of various lipolytic enzymes in modifying the composition of a milk polar lipid concentrate. In this work, 8 microbial lipases of variable specificity and of variable level of annex phospholipase activity and 2 phospholipases (PLA1 and PLA2) have been used to catalyze the hydrolysis of a milk polar lipid concentrate. The initial lipid composition of the milk polar lipid concentrate was: 7 % triacylglycerides (TAG), 23 % phosphatidylethanolamine (PE), 11 % phosphatidylinositol (PI) , 4 % phosphatidylserine (PS), 41 % sphingomyelin (SM). After 4 hours hydrolysis, lipid classes were quantified by high performance liquid chromatography. The highest hydrolysis levels were obtained using: PLA1 > PLA2 > M. miehei lipase. Lipases generally triggered a specific enrichment in polar lipids through a preferential hydrolysis of apolar lipids whithout modifying the polar lipids profile. Except for M. Miehei lipase which presented a high annex phospholipase activity and decreased both TAG content and PE content. PLA2 and PLA1 led respectively to a final composition dominated by PI, PC and SM on one hand and SM only on the other hand. Phospholipases allowed the obtention of an ingredient highly concentrated in sphingomyelin which could be an interesting precursor of ceramides. The potential of these biocatalyzers to modulate milk polar lipids composition was thus underlined
Efficient quasi-phase matching in periodically-twinned quartz (2005)

We demonstrate 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> -order QPM SHG in periodically-twinned quartz under tight focusing condition of a Nd:YAG laser. Owing to large temperature bandwidth, stable and efficient green light of 31 mW was obtained without temperature control
Le suivi visuel à l'aide de mondes clos (2000)

Intille Stephen S., Bobick Aaron F. Le suivi visuel à l'aide de mondes clos. In: Les Cahiers de l'INSEP, n°26, 2000. Informatique et sports collectifs. pp. 31-55.
Tissue Factor Expression, Angiogenesis, and Thrombosis in Pancreatic Cancer (2007)

TF expression occurs early in pancreatic neoplastic transformation and is associated with VEGF expression, increased microvessel density, and possibly clinical venous thromboembolism in pancreatic cancer. Prospective studies evaluating the role of TF in pancreatic cancer outcomes are warranted.
Risk Based Adaptation to Climate Change (2011)

This paper presents the optimization of the consumption and production rates of a steam reforming plant using natural gas as raw material for generating hydrogen as principal product.Different strategies are applied to select the most adequate techniques and to obtain different configurations or alternatives for the process.The methodology used in this work includes both quantitative and qualitative analyses.The aim of this work is to apply various possible alternatives to control emissions and reduce energy inputs, according to the recommendations of the European IPPC Bureau and the United Nations Framework Convention on Climate Change.The actions are oriented towards reducing the consumption of the plant by improving process heat recovery and improving energy integration.The results will be focused on the energy consumption analysis for the different alternatives, showing the best option to design the plant, maximizing production and optimizing energy use.This approach produces large amounts of hydrogen, decreases environmental impacts and increases economical profits.
Skeletal Muscle-derived Hematopoietic Stem Cells: Muscular Dystrophy Therapy by Bone Marrow Transplantation (2012)

For postnatal growth and regeneration of skeletal muscle, satellite cells, a self-renewing pool of muscle stem cells, give rise to daughter myogenic precursor cells that contribute to the formation of new muscle fibers. In addition to this key myogenic cell class, adult skeletal muscle also contains hematopoietic stem cell and progenitor cell populations which can be purified as a side population (SP) fraction or as a hematopoietic marker CD45-positive cell population. These muscle-derived hematopoietic stem/progenitor cell populations are surprisingly capable of differentiation into hematopoietic cells both after transplantation into irradiated mice and during <i>in vitro</i> colony formation assay. Therefore, these muscle-derived hematopoietic stem/progenitor cells appear to have characteristics similar to classical hematopoietic stem/progenitor cells found in bone marrow. This review outlines recent findings regarding hematopoietic stem/progenitor cell populations residing in adult skeletal muscle and discusses their myogenic potential along with their role in the stem cell niche and related cell therapies for approaching treatment of Duchenne muscular dystrophy.
Structure of crossing-shock wave/turbulent boundary-layer interactions (1992)

A detailed comparison of experimental and computational results on the flowfield structure of a Mach 4, 15-deg symmetric crossing-shock-wave/turbulent-boundary-layer interaction is presented. Experimentally obtained planar laser scattering images are compared with static-pressure contours predicted by the computation.
Copper catalysis at operando conditions—bridging the gap between single nanoparticle probing and catalyst-bed-averaging (2020)

In catalysis, nanoparticles enable chemical transformations and their structural and chemical fingerprints control activity. To develop understanding of such fingerprints, methods studying catalysts at realistic conditions have proven instrumental. Normally, these methods either probe the catalyst bed with low spatial resolution, thereby averaging out single particle characteristics, or probe an extremely small fraction only, thereby effectively ignoring most of the catalyst. Here, we bridge the gap between these two extremes by introducing highly multiplexed single particle plasmonic nanoimaging of model catalyst beds comprising 1000 nanoparticles, which are integrated in a nanoreactor platform that enables online mass spectroscopy activity measurements. Using the example of CO oxidation over Cu, we reveal how highly local spatial variations in catalyst state dynamics are responsible for contradicting information about catalyst active phase found in the literature, and identify that both surface and bulk oxidation state of a Cu nanoparticle catalyst dynamically mediate its activity.
The catalytic mechanism of protein tyrosine phosphatases revisited (2001)

Experimental and theoretical studies of the catalytic mechanism in protein tyrosine phosphatases and dual specific phosphatases are reviewed. The structural properties of these enzymes contributing to the efficient rate enhancement of phosphate monoester hydrolysis have been established during the last decade. There are, however, uncertainties in the interpretation of available experimental data that make the commonly assumed reaction mechanism somewhat doubtful. Theoretical calculations as well as analysis of crystal structures point towards an alternative interpretation of the ionisation state in the reactive complex.
Lack of effect of chronic morphine treatment and naloxone‐precipitated withdrawal on tyrosine hydroxylase, galanin, and neuropeptide Y mRNA levels in the rat locus coeruleus (1995)

Morphine dependence was experimentally induced in rats by daily injection of increasing doses of morphine for seven days. Withdrawal was precipitated in half of the morphine-dependent rats by a single injection of naloxone on day 8. Behavioral signs of withdrawal were evident in the morphine/naloxone group. Gene expression in locus coeruleus (LC) neurons was investigated using quantitative in situ hybridization analysis. Messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, and for precursors to galanin (GAL) and neuropeptide Y (NPY), peptides that coexist with norepinephrine in LC neurons, were not altered by chronic morphine treatment or naloxone-precipitated withdrawal. In contrast, mRNA levels for c-fos were dramatically elevated in the LC following naloxone-precipitated withdrawal. Chronic morphine treatment caused a small decrease in levels of mRNA encoding the precursor to corticotropin-releasing factor (CRF) in Barrington's nucleus. Although long-term adaptations of LC neurons have previously been implicated in the development of morphine tolerance, dependence, and withdrawal, alterations in the levels of TH, GAL, or NPY mRNA in the LC apparently do not underlie this process.
Humanized mAb H22 binds the human high affinity Fc receptor for IgG (FcγRI), blocks phagocytosis, and modulates receptor expression (1997)

About 10-15% of patients with immune thrombocytopenic purpura (ITP) cannot be controlled by corticosteroid therapy and splenectomy. For these patients treatment with high-dose IVIgG induces partial or complete responses. The clinical benefits of IVIgG could be due to blockade of Fc receptors for IgG (FcgammaR), because several model systems clearly show that functional FcgammaR are essential for establishment of ITP and related diseases. However, the specific contributions of the three individual classes of FcgammaR remain to be more completely defined. Recently monoclonal antibody (mAb) H22, which recognizes an epitope on FcgammaRI (CD64) outside the ligand binding domain, was humanized by grafting its complementarity determining regions onto human IgG1 constant domains. Because FcgammaRI has a high affinity for human IgG1 antibodies, we predicted mAb H22 would also bind to FcgammaRI through its Fc domain and block FcgammaRI-mediated phagocytosis. These studies demonstrate that mAb H22 blocked phagocytosis of opsonized red blood cells 1000 times more effectively than an irrelevant IgG. Moreover, cross-linking FcgammaRI with mAb H22 rapidly down-modulated FcgammaRI expression on monocytes without affecting other surface antigens. We conclude that because mAb H22 is a humanized mAb that blocks the FcgammaRI ligand binding domain and down-modulates FcgammaRI expression, it is a particularly good candidate for evaluating the role of FcgammaRI in patients with ITP.
A practical multiphase IPT system for AGV and roadway applications (2010)

Recent advances in Inductive Power Transfer (IPT) technology have made it possible to transfer enough power across an air gap of sufficient size that electric vehicles can receive operational power and be charged while they are in motion on a roadway. However, in order to provide the vehicle with the required tolerance to lateral movement, bulky pickups or complex track arrangements are required. The challenge is to provide the vehicle as much freedom of movement as possible so that drivers are not artificially restricted, while utilizing a simple and low cost pickup, track and power supply. This paper will show that a simple, low cost two-phase track and power supply system can provide similar benefits to a more complex three-phase system, while also lowering the system cost with a simpler installation. A quadrature pickup provides additional benefits in maintaining a constant power transfer across the width of the roadway. Used together, these provide the vehicle with high freedom of movement, and a low total system cost.
Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin (2013)

A biocatalytic platform that employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro followed by direct appendage of D-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the synthesis of a suite of 12- and 14-membered ring macrolide natural products. This methodology delivered both compound classes in 13 steps (longest linear sequence) from commercially available (R)-Roche ester in >10% overall yields.
Dependence on the beam detection position in the beam profile measurement on a rotating optical disk (1998)

With a working drive it is difficult to dynamically measure the beam profile formed on the optical disk because of the rotation of the disk and the movement of optical head due to auto focusing. We have developed the measurement method of the beam profile on a rotating optical disk, which is based on the scanning knife edge method[1]. To apply this method to an actual drive, we proposed two techniques. The first one is to detect the transmission light through the measurement disk with an external PIN photodetector, and the second is to detect the reflection light by using the built-in photodetector of the drive(Fig.1)[2]. The merits and demerits of both measurement techniques are clarified by comparing each other. We present the Influence of the distance between the detector and the disk.
Photothermal surface-micromachined actuators (2003)

We report on the optical actuation of surface micromachines. Optical energy is absorbed by the micromachines and converted to heat, which causes differential thermal expansion between different parts of the device and up to 12 /spl mu/m of displacement. The polysilicon actuators are homogenous and electrically isolated.
Novel base-induced isomerization of unsaturated alcohols to aldehydes (1985)

A number of allylic and other unsaturated alcohols have been converted into aldehydes by treatment with N-lithioethylenediamine in ethylenediamine (LEDA–EDA) and also with lithium 3-aminopropanamide in 3-amino-propanamine (LAPA–APA).
Photoemission study of amorphous carbon modifications and comparison with calculated densities of states (1996)

In this study we present photoemission data for three different types of amorphous carbon modifications (a-C:H, ta-C:H, and ta-C) that owe their properties to their different preparations by radio frequency plasma, plasma beam, or arc discharge. Their properties are investigated by means of their characteristic plasmon loss following the C 1s core level, the core-level shape itself, and by their valence bands. For all three amorphous modifications as well as for the two crystalline ones, diamond and graphite, we present density of states calculations which in the amorphous case are based on molecular-dynamics simulations. The electronic density of states is fitted to the data using photoemission cross sections and a model for the lifetime broadening. The agreement achieved is very good and confirms the validity of the predicted structures that do not possess any significant larger \ensuremath{\pi} clusters. \textcopyright{} 1996 The American Physical Society.
A 2.4 Gb/s/pin simultaneous bidirectional parallel link with per pin skew compensation (2002)

A 8 b-wide single-ended simultaneous bidirectional transceiver test chip in a 0.4 /spl mu/m CMOS process allows study of the major challenges in high-performance, low-cost parallel-link design. This paper shows the I/O cell and placement of I/O pads in each chip. Data pins are laid out with different signal return configurations to study cross-talk in parallel links. In the I/O cell, the open-drain output driver is broken down into 4 legs ratioed 1:2:4:4 for swing control. The line is terminated on each side with a pMOS resistor, whose gate voltage is adjusted externally for impedance control. Two externally-adjustable reference voltages (VrefH and VrefL) are multiplexed to generate the local reference voltage (Vref) to decode incoming data. The I/O design operates at a bit time equal to 4 fanout-of-4 delays (FO4=delay of an inverter driving a load of 4 identical inverters and is 193 ps at a 3.3 V supply in this run). The bidirectional links operate at 2.4 Gb/s/pin (1.2 Gb/s in each direction), with 200 mV minimum signal swing on each side for the pins with worst-ease cross-talk.
Short-term LDL cholesterol-lowering efficacy of plant stanol esters (2002)

The specific effect of plant stanol esters on serum LDL cholesterol can fully be obtained within 1-2 weeks of the use of plant stanol ester-enriched margarine.
MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation (2012)

MicroRNAs (miRNAs) have an important role in the development of chemosensitivity or chemoresistance in different types of cancer. Activation of the ERK1/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important miRNAs. Here we show a link between the ERK1/2 pathway and BIM expression through miR-494. We blocked ERK1/2 nuclear activity through the overexpression of an ERK1/2 natural interactor, the protein PED/PEA15, and we performed a microRNA expression profile. miR-494 was the most down-regulated microRNA after ERK1/2 inactivation. Moreover, we found that miR-494 induced Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance in non-small-cell lung cancer (NSCLC) through the down-modulation of BIM. Elucidation of this undiscovered ERK1/2 pathway that regulates apoptosis and cell proliferation through miR-494 in NSCLC will greatly enhance our understanding of the mechanisms responsible for TRAIL resistance and will provide an additional arm for the development of anticancer therapies.
GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo (2016)

GM-CSF substantially augments glycolytic flux in vitro (via a mechanism dependent on ubiquitous type 6-phosphofructo-2-kinase and tumor necrosis factor-α) and increases (18)F-FDG uptake within inflamed atheroma in vivo. These findings demonstrate that GM-CSF can be used to enhance detection of inflammation. Further studies should explore the role of GM-CSF stimulation to enhance the detection of inflammatory foci in other disease states.
Stability of cylindrical domains in phase-separating binary fluids in shear flow (1998)

The stability of a long cylindrical domain in a phase-separating binary fluid in an external shear flow is investigated by linear stability analysis. Using the coupled Cahn-Hilliard and Stokes equations, the stability eigenvalues are derived analytically for long-wavelength perturbations, for arbitrary viscosity contrast between the two phases. The shear flow is found to suppress and sometimes completely stabilize both the hydrodynamic Rayleigh instability and the thermodynamic instability of the cylinder against varicose perturbations, by mixing with nonaxisymmetric perturbations. The results are consistent with recent observations of a ``string phase'' in phase-separating fluids in shear.
First‐in‐man study of ACT‐709478, a novel selective triple T‐type calcium channel blocker (2019)

ACT-709478 exhibits good tolerability and safety after single-dose administration and its pharmacokinetic and pharmacodynamic properties warrant further investigations.
Abstract 19082: Cellular Iron Regulates Mitochondrial Dynamics and Mitophagy Through the RNA-Binding Protein Tristetraprolin (2017)

Background: Iron is a critical molecule for normal cellular and physiologic processes including mitochondrial energy production and oxygen transport in the blood. Previous work in our lab has established the RNA-binding protein TTP as an iron-responsive gene whose expression is induced by iron deprivation. TTP functions by binding to AU-rich elements in the 3’UTR of mRNAs and promotes their degradation. Iron deprivation is a form of cellular stress linked to alterations in mitochondrial dynamics. Optic atrophy 1 (OPA1) is a critical component of the mitochondrial fusion machinery and, under conditions of cellular stress, OPA1 is proteolytically cleaved to promote mitochondrial fission and recycling of damaged mitochondria. OPA1 expression and cleavage is altered in cardiomyopathy, and heterozygous mice develop spontaneous cardiomyopathy. We hypothesize that induction of TTP by low iron reduces the level of OPA1 to fragment the mitochondria and allow for mitophagic recycling of non-functional mitochondria....