gebhart/patrepeval huggingface dataset:
Design and evaluation of real-time communication for FieldBus based manufacturing systems (2003)

A strategy for handling real-time communications under the FieldBus protocol, which provides end-to-end delivery delay guarantees for time-critical messages, is proposed. This strategy provides a fast local mechanism for establishing intraworkcell real-time connections, while supporting global interworkcell real-time connections. The proposed strategy is fully compatible with the current draft proposal of the FieldBus protocol and also provides flexibility for the choice of scheduling algorithms and adaptability for different traffic loads. Numerical examples are given based on a typical manufacturing network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes. (1978)

Microsomes prepared from embryonic chick bone contain a vitamin K-dependent carboxylating system which post-translationally converts glutamic acid residues in peptides to gamma-carboxyglutamic acid (gamma-CGlu). Glutamic acid residues in both endogenous chick bone microsomal protein and in the synthetic peptide Phe Leu-Glu-Glu-Val are gamma-carboxylated. These data suggest that bone cells have the capacity for de novo gamma-CGlu synthesis and may be responsible for synthesis of osteocalcin, the major gamma-CGlu protein in bone.
The Role of Corn Breeding in Future Northeastern Crop Production (1993)

The hybridization concepts of G. H. Shull and D. F. Jones unlocked the genetic potential of corn and accelerated progress from corn breeding efforts. Corn breeding has altered several traits which adapt corn to modern agronomic practices. In support of livestock industries in the Northeastern (N.E.), and particularly in light of increased demand for dairy products and projected increases in productivity per cow, both corn grain and corn silage production in the N.E. are expected to increase. Certain value-added traits amenable to improvement by plant breeding could benefit the farmer directly, rather than benefiting primarily off-farm processors. Several issues impinging on plant breeding will affect the role of com breeding in future N.E. crop production and hence deserve brief discussion. The chapter assesses historical contributions of com breeding to N.E. agriculture, the role of com in future N.E. production systems, and the future directions and contributions of com breeding to those systems.
A DC-102GHz broadband amplifier in 0.12&#x00B5;m SiGe BiCMOS (2009)

An ultra-wideband amplifier scheme is realized with two cascaded stages that are equalized for high-bandwidth and low gain ripple. The amplifier is implemented in a 0.12 mum SiGe BiCMOS process and achieves a 3 dB bandwidth of 102 GHz. The gain is 10 dB with less than 1.5 dB gain-ripple and group-delay variation under +/- 6 ps over the entire 3 dB bandwidth. The chip occupies an area of 0.29 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> including the pads and consumes 73 mW from a 2 V supply.
Volume holography for 1550nm digital databases (2000)

It’s well known that volume holography makes it possible to record real information databases by overlapping multiple holograms within the same volume and accessing them independently. Furthermore in the last years the increasing achievement of optical communication systems operating in the third window of optical communication systems (1550nm) is giving a strong impulse to the implementation of all-optical devices useful to process Wavelength Division Multiplexed (WDM) information signals.
Ultrafast and continuous synthesis of crystalline ferrite nanoparticles in supercritical ethanol (2013)

Magnetic nanoparticles (NPs) are of increasing interest in various industrially relevant products. For these, the development of greener and faster approaches facilitating scaling-up production is of paramount importance. Here, we report a novel, green and potentially scalable approach for the continuous and ultrafast (90 s) synthesis of superparamagnetic ferrite NPs (MnFe(2)O(4), Fe(3)O(4)) in supercritical ethanol (scEtOH) at a fairly moderate temperature (260 °C). ScEtOH exhibits numerous advantages such as its production from bio-resources, its lack of toxicity and its relatively low supercritical coordinates (p(c) = 6.39 MPa and T(c) = 243 °C), being therefore appropriate for the development of sustainable technologies. The present study is completed by the investigation of both in situ and ex situ NP surface functionalization. The as-obtained nanoparticles present good crystallinity, sizes below 8 nm, superparamagnetic behavior at room temperature and high saturation magnetization. Moreover, depending on the capping strategy, the ferrite NPs present extended (for in situ coated NPs) or short-term (for ex situ coated NPs) colloidal stability.
МЕХАНИЗМ ПРОТИВОВОСПАЛИТЕЛЬНОГО ДЕЙСТВИЯ ПЕПТИДА GLU-TRP (2014)

Целью исследования являлся анализ взаимодействия пептида Glu-Trp с ферментами каскада арахидоновой кислоты циклооксигеназой-1 и 2 (ЦОГ1/2). Ферменты ЦОГ1/2 катализируют реакции оксигенации полиненасыщенных жирных кислот, главным образом арахидоновой кислоты, с образованием класса липидных соединений простаноидов, ответственных за инициацию, пролонгацию и завершение воспалительного процесса. Установлено, что пептид Glu-Trp является неспецифическим ингибитором двух изоформ циклооксигеназы.
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure 2. Expression of PCAT29 in LNCaP cells.&lt;/p&gt;
Transcriptome and translatome of CO2 fixing acetogens under heterotrophic and autotrophic conditions (2021)

Acetogens are anaerobic bacteria that utilise gaseous feedstocks such as carbon monoxide (CO) and carbon dioxide (CO<sub>2</sub>) to synthesise biomass and various metabolites via the energetically efficient Wood-Ljungdahl pathway. Because of this pathway, acetogens have been considered as a novel platform to produce biochemicals from gaseous feedstocks, potentially replacing the conventional thermochemical processes. Despite their advantages, a lack of systematic understanding of the transcriptional and translational regulation in acetogens during autotrophic growth limits the rational strain design to produce the desired products. To overcome this problem, we presented RNA sequencing and ribosome profiling data of four acetogens cultivated under heterotrophic and autotrophic conditions, providing data on genome-scale transcriptional and translational responses of acetogens during CO<sub>2</sub> fixation. These data facilitate the discovery of regulatory elements embedded in their genomes, which could be utilised to engineer strains to achieve better growth and productivity. We anticipate that these data will expand our understanding of the processes of CO<sub>2</sub> fixation and will help in the designing of strains for the desired biochemical production.
Reversible (unitised) PEM fuel cell devices (1999)

Regenerative fuel cells (RFCs) are enabling for many weight-critical portable applications, since the packaged specific energy (>400 Wh/kg) of properly designed lightweight RFC systems is several-fold higher than that of the lightest-weight rechargeable batteries. RFC systems can be rapidly refueled (like primary fuel cells), or can be electrically recharged (like secondary batteries) if a refueling infrastructure is not conveniently available. Higher energy capacity systems with higher performance, reduced weight and freedom from fueling infrastructure are the features that RFCs promise for portable applications. Reversible proton exchange membrane (PEM) fuel cells, also known as unitised regenerative fuel cells (URFCs), or reversible regenerative fuel cells, are RFC systems which use reversible PEM cells, where each cell is capable of operating both as a fuel cell and as an electrolyser. URFCs further economise portable device weight, volume and complexity by combining the functions of fuel cells and electrolysers in the same hardware, generally without any system performance or efficiency reduction. URFCs are being made in many forms, some of which are already small enough to be portable. Lawrence Livermore National Laboratory (LLNL) has worked with industrial partners to design, develop and demonstrate high-performance and high-cycle-life URFC systems. LLNL is also working with industrial partners to develop breakthroughs in lightweight pressure vessels that are necessary for URFC systems to achieve the specific energy advantages over rechargeable batteries. Proton Energy Systems Inc is concurrently developing and commercialising URFC systems (its Unigen;product lproduct line), in addition to PEM electrolyser systems (the Hogen;product lproduct line), and primary PEM fuel cell systems. LLNL is constructing demonstration URFC units in order to persuade potential sponsors, often in their own conference rooms, that advanced applications based on URFCs are feasible. Safety and logistics force these URFC demonstration units to be small, transportable and easily set up, hence they already prove the viability of URFC systems for portable applications.
Investigating Current and Radial Shaft Displacement of Induction Motor Driven by Pulse-Width Modulation Inverter for Bearing Fault Detection (2019)

Bearing faults account for a large majority of the faults in three-phase induction motors. Many researches have been conducted to develop a diagnosis technique for bearing faults using the motor current in an induction motor. However, the characteristics of the motor stator current and radial shaft displacement have not yet been clarified when there is a faulty bearing in an induction motor driven by a PWM inverter. The purpose of this paper is to investigate the relationship between the power spectral density of the rotational frequency band of the stator current and the radial shaft displacement of the induction motor driven by a PWM inverter. Experiments were performed with normal and abnormal motors. Then, the characteristics of the power spectral density of the rotational frequency band of the stator current are discussed based on the experimental results of the radial shaft displacement.
Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review (2021)

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbances. Neuropathological studies show that disease progression follows a characteristic pattern of brain atrophy, beginning in the basal ganglia structures. The HD Regulatory Science Consortium (HD-RSC) brings together diverse stakeholders in the HD community-biopharmaceutical industry, academia, nonprofit, and patient advocacy organizations-to define and address regulatory needs to accelerate HD therapeutic development. Here, the Biomarker Working Group of the HD-RSC summarizes the cross-sectional evidence indicating that regional brain volumes, as measured by volumetric magnetic resonance imaging, are reduced in HD and are correlated with disease characteristics. We also evaluate the relationship between imaging measures and clinical change, their longitudinal change characteristics, and within-individual longitudinal associations of imaging with disease progression. This analysis will be valuable in assessing pharmacodynamics in clinical trials and supporting clinical outcome assessments to evaluate treatment effects on neurodegeneration.
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro (2023)

Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-443902), which acts as a potent inhibitor of viral RNA-dependent RNA polymerases. Remdesivir and GS-441524 have antiviral activity against multiple RNA viruses. Here, we expand the evaluation of remdesivir's antiviral activity to members of the families Flaviviridae, Picornaviridae, Filoviridae, Orthomyxoviridae, and Hepadnaviridae. Using cell-based assays, we show that remdesivir can inhibit infection of flaviviruses (such as dengue 1-4, West Nile, yellow fever, Zika viruses), picornaviruses (such as enterovirus and rhinovirus), and filoviruses (such as various Ebola, Marburg, and Sudan virus isolates, including novel geographic isolates), but is ineffective or is significantly less effective against orthomyxoviruses (influenza A and B viruses), or hepadnaviruses B, D, and E. In addition, remdesivir shows no antagonistic effect when combined with favipiravir, another broadly acting antiviral nucleoside analog, and has minimal interaction with a panel of concomitant medications. Our data further support remdesivir as a broad-spectrum antiviral agent that has the potential to address multiple unmet medical needs, including those related to antiviral pandemic preparedness.
Toward Fully Printed Soft Actuators: UV‐Assisted Printing of Liquid Crystal Elastomers and Biphasic Liquid Metal Conductors (2023)

Abstract Development of soft and compliant actuators has attracted tremendous attention due to their use in soft robotics, wearables, haptics, and assistive devices. Despite decades of progress, the goal of entirely digitally‐printed actuators has yet to be fully demonstrated. Digital printing permits rapid customization of the actuator's geometry, size, and deformation profile, and is a step toward mass customization of user‐specific wearables and soft robotic systems. Herein, a set of materials and methods are demonstrated for rapid fabrication of 3D‐printed Liquid Crystal Elastomer actuators electrically stimulated via a printed joule heater composed of a Liquid Metal (LM)‐filled elastomer composite. Unlike other Ag‐based inks, this LM‐elastomer composite is sinter‐free, enabling room‐temperature printing, and is stretchable, allowing cyclic actuation without electrical or mechanical failure of the conductor. By optimizing printing parameters, and improving the photo‐polymerization setup, a printed actuator that bends to an angle of 320° is demonstrated, with lower power consumption than previous LCE actuators. We also demonstrate a customized UV‐polymerization setup that permits photo‐curing of the LCE actuator in ≈90s, i.e., &gt;500x faster compared to previous works. The rapid photo‐polymerization enables progress toward 3D‐printing of multi‐layer actuators and is a step toward mass customization of fully digitally‐printed robotic and wearable devices.
Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch (2016)

Lysine-specific histone demethylase 1 (LSD1) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells (iPSCs). Here we reported that LSD1 inhibition via shRNA or specific inhibitor, tranylcypromine, promoted reprogramming at early stage via two mechanisms. At early stage of reprogramming, LSD1 inhibition increased the retrovirus-mediated exogenous expression of Oct4, Klf4, and Sox2 by blocking related H3K4 demethylation. Since LSD1 inhibition still promoted reprogramming even when iPSCs were induced with small-molecule compounds in a virus-free system, additional mechanisms should be involved. When RNA-seq was used for analysis, it was found that LSD1 inhibition reversed some gene expression changes induced by OKS, which subsequently promoted reprogramming. For example, by partially rescuing the decreased expression of Hif1α, LSD1 inhibition reversed the up-regulation of genes in oxidative phosphorylation pathway and the down-regulation of genes in glycolysis pathway. Such effects facilitated the metabolic switch from oxidative phosphorylation to glycolysis and subsequently promoted iPSCs induction. In addition, LSD1 inhibition also promoted the conversion from pre-iPSCs to iPSCs by facilitating the similar metabolic switch. Therefore, LSD1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch.
Discrimination and Classification – Supervised Learning (2011)

This chapter contains sections titled: Introduction Classification for Two Populations Classification for Several Populations Spatial Smoothing for Classification Further Reading
The unique second wave phenomenon in contrast enhanced ultrasound imaging with nanobubbles (2022)

Investigation of nanobubble (NB) pharmacokinetics in contrast-enhanced ultrasound (CEUS) at the pixel level shows a unique phenomenon where the first pass of the contrast agent bolus is accompanied by a second wave. This effect has not been previously observed in CEUS with microbubbles. The objective of this study was to investigate this second-wave phenomenon and its potential clinical applications. Seven mice with a total of fourteen subcutaneously-implanted tumors were included in the experiments. After injecting a bolus of NBs, the NB-CEUS images were acquired to record the time-intensity curves (TICs) at each pixel. These TICs are fitted to a pharmacokinetic model which we designed to describe the observed second-wave phenomenon. The estimated model parameters are presented as parametric maps to visualize the characteristics of tumor lesions. Histological analysis was also conducted in one mouse to compare the molecular features of tumor tissue with the obtained parametric maps. The second-wave phenomenon is evidently shown in a series of pixel-based TICs extracted from either tumor or tissues. The value of two model parameters, the ratio of the peak intensities of the second over the first wave, and the decay rate of the wash-out process present large differences between malignant tumor and normal tissue (0.04 < Jessen-Shannon divergence < 0.08). The occurrence of a second wave is a unique phenomenon that we have observed in NB-CEUS imaging of both mouse tumor and tissue. As the characteristics of the second wave are different between tumor and tissue, this phenomenon has the potential to support the diagnosis of cancerous lesions.
Proteomic profiling of KATP channel‐deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome (2009)

KCNJ11 null mutants, lacking Kir6.2 ATP-sensitive K(+) (K(ATP)) channels, exhibit a marked susceptibility towards hypertension (HTN)-induced heart failure. To gain insight into the molecular alterations induced by knockout of this metabolic sensor under hemodynamic stress, wild-type (WT) and Kir6.2 knockout (Kir6.2-KO) cardiac proteomes were profiled by comparative 2-DE and Orbitrap MS. Despite equivalent systemic HTN produced by chronic hyperaldosteronism, 114 unique proteins were altered in Kir6.2-KO compared to WT hearts. Bioinformatic analysis linked the primary biological function of the K(ATP) channel-dependent protein cohort to energetic metabolism (64% of proteins), followed by signaling infrastructure (36%) including oxidoreductases, stress-related chaperones, processes supporting protein degradation, transcription and translation, and cytostructure. Mapped protein-protein relationships authenticated the primary impact on metabolic pathways, delineating the K(ATP) channel-dependent subproteome within a nonstochastic network. Iterative systems interrogation of the proteomic web prioritized heart-specific adverse effects, i.e., "Cardiac Damage", "Cardiac Enlargement", and "Cardiac Fibrosis", exposing a predisposition for the development of cardiomyopathic traits in the hypertensive Kir6.2-KO. Validating this maladaptive forecast, phenotyping documented an aggravated myocardial contractile performance, a massive interstitial fibrosis and an exaggerated left ventricular size, all prognostic indices of poor outcome. Thus, Kir6.2 ablation engenders unfavorable proteomic remodeling in hypertensive hearts, providing a composite molecular substrate for pathologic stress-associated cardiovascular disease.
Differentially-Private Mining of Representative Travel Patterns (2016)

Mobile users participate in numerous social media applications that revolve around user locations, and receive customized services and recommendations tailored to their whereabouts. Large amounts of trajectory data become available as a byproduct of such services. Studying such data reveals travel patterns which can benefit transportation planning, public safety, etc. However, disclosing such data may lead to serious breaches of privacy. We propose a privacy-preserving approach to mining representative travel patterns using differential privacy (DP). Our solution consists of a sampling algorithm based on the exponential mechanism (EM) of DP which uses public road network information to increase sanitization accuracy. Extensive experimental results on realistic workloads show that the proposed protection technique preserves data precision and is computationally efficient.
Power Electronics Powertrain Architectures for Hybrid and Solar Electric Airplanes with Distributed Propulsion (2018)

Distributed propulsion in aircraft has been shown to increase reliability and benefit aerodynamic performance. This paper discusses power electronic architectures and proposes control schemes suitable for distributed propulsion in hybrid and electric airplanes. Hybrid electric airplanes include permanent magnet synchronous generators driven by jet engines. The output of the generators is connected to the propulsion motors through back to back voltage source converters. Batteries, connected to the DC bus through buck-boost converters, are used to provide additional power to the propulsion motors during take off and climb. In the case of electric airplanes, the jet engine-permanent magnet generator system is replaced by solar photovoltaic (PV) panels. The output of the solar PV system is controlled such that it operates at its maximum power point, and power is provided to batteries and propulsion motors. Simulation results on both hybrid and solar electric systems are presented.
Gramazio Kohler Research, Automated Diversity: New Morphologies of Vertical Urbanism (2015)

Automated fabrication techniques are currently largely confined to the production of discrete objects or building elements. To notch up the potential of robotics for architectural design, it is necessary to start to push the limits and experiment at a larger urban scale. Fabio Gramazio and Matthias Kohler are pioneers in this field. Here, with Jan Willmann , they describe the research that they are undertaking as part of the Future Cities Laboratory (FCL) located at the Singapore‐ETH Centre for Global Environmental Sustainability (SEC) and ETH Zurich, in which robotic fabrication technologies are employed to realize 1:50 physical models of mixed‐use high‐rise structures that are unique in their spatial layouts.
Angle Diversity for an Indoor Cellular Visible Light Communication System (2014)

In this paper, we investigate the benefits of an angle diversity receiver (ADR) in an indoor cellular optical wireless communications (OWC) network. As the ADR consists of multiple photodiodes (PDs), a proper signal combining scheme is essential to optimise the system performance. Therefore, three different combination schemes, the equal gain combining (EGC), the select best combining (SBC) and the maximum ratio combining (MRC), are investigated. The results indicate that the ADR significantly outperforms the single-PD receiver in terms of both signal to interference plus noise ratio (SINR) and area spectral efficiency (ASE). In particular, the ADR implementing the MRC scheme achieves the best performance, where over 40 dB SINR improvement is attained compared to the single-PD receiver.