gebhart/patrepeval huggingface dataset:
Synthesis of polyamides containing dipeptide linkages (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of polyamides containing dipeptide linkagesP. M. Mungara and K. E. GonsalvesCite this: Chem. Mater. 1993, 5, 9, 1242–1246Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/cm00033a010https://doi.org/10.1021/cm00033a010research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of semantic role labeling and dependency parsing of automatic speech recognition output (2010)

Semantic role labeling (SRL) is an important module of spoken language understanding systems. This work extends the standard evaluation metrics for joint dependency parsing and SRL of text in order to be able to handle speech recognition output with word errors and sentence segmentation errors. We propose metrics based on word alignments and bags of relations, and compare their results on the output of several SRL systems on broadcast news and conversations of the OntoNotes corpus. We evaluate and analyze the relation between the performance of the subtasks that lead to SRL, including ASR, part-of-speech tagging or sentence segmentation. The tools are made available to the community.
Spatio-Temporal Characterization of a Conical Swirler Flow Field Under Strong Forcing (2008)

In this study, a spatio-temporal characterization of forced and unforced flows of a conical swirler is done based on Particle Image Velocimetry (PIV) and Laser Doppler Anemometry (LDA). The measurements are performed at a Reynolds number of 33,000 and a swirl number of 0.71. Axisymmetric forcing is applied to approximate the effects of thermoacoustic instabilities on the flow field at the burner inlet and outlet. The actuation frequencies are set at the natural flow frequency (Strouhal number Stf ≈ 0.92) and two higher frequencies (Stf ≈ 1.3 and 1.55) that are not harmonically related. Phase locked and phase averaged measurement are used as a first step to visualize the coherent flow structures. Secondly, Proper Orthogonal Decomposition (POD) is applied to the PIV data to characterize the effect of the actuation on the fluctuating flow. Measurements indicate a typical natural flow instability of helical nature in the unforced case. The associated induced pressure and flow oscillations travel upstream to the swirler inlet where generally fuel is injected. This observation is of critical importance with respect to the stability of the combustion. Harmonic actuation at different frequencies and amplitudes affects the mean-field profile most at the outlet, while the coherent velocity fluctuations are strongly influenced at both inlet and outlet. On one hand, the dominant helical mode is replaced by an axisymmetric vortex ring if the flow is forced at the natural flow frequency. On the other hand, the natural flow frequency prevails at the outlet under forcing at higher frequencies and POD analysis indicates that the helical structure is still present. The presented results give new insight into the flow dynamics of a swirling flow burner under strong forcing.
The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks (2022)

Mismatch repair (MMR) is a replication-coupled DNA repair mechanism and plays multiple roles at the replication fork. The well-established MMR functions include correcting misincorporated nucleotides that have escaped the proofreading activity of DNA polymerases, recognizing nonmismatched DNA adducts, and triggering a DNA damage response. In an attempt to determine whether MMR regulates replication progression in cells expressing an ultramutable DNA polymerase ɛ (Polɛ), carrying a proline-to-arginine substitution at amino acid 286 (Polɛ-P286R), we identified an unusual MMR function in response to hydroxyurea (HU)-induced replication stress. Polɛ-P286R cells treated with hydroxyurea exhibit increased MRE11-catalyzed nascent strand degradation. This degradation by MRE11 depends on the mismatch recognition protein MutSα and its binding to stalled replication forks. Increased MutSα binding at replication forks is also associated with decreased loading of replication fork protection factors FANCD2 and BRCA1, suggesting blockage of these fork protection factors from loading to replication forks by MutSα. We find that the MutSα-dependent MRE11-catalyzed fork degradation induces DNA breaks and various chromosome abnormalities. Therefore, unlike the well-known MMR functions of ensuring replication fidelity, the newly identified MMR activity of promoting genome instability may also play a role in cancer avoidance by eliminating rogue cells.
Extracorporeal photochemotherapy induces bona fide immunogenic cell death (2019)

Extracorporeal photochemotherapy (ECP) is employed for the management of cutaneous T cell lymphoma (CTCL). ECP involves the extracorporeal exposure of white blood cells (WBCs) to a photosensitizer, 8-methoxypsoralen (8-MOP), in the context of ultraviolet A (UVA) radiation, followed by WBC reinfusion. Historically, the therapeutic activity of ECP has been attributed to selective cytotoxicity on circulating CTCL cells. However, only a fraction of WBCs is exposed to ECP, and 8-MOP is inactive in the absence of UVA light, implying that other mechanisms underlie the anticancer effects of ECP. Recently, ECP has been shown to enable the physiological differentiation of monocytes into dendritic cells (DCs) that efficiently cross-present tumor-associated antigens (TAAs) to CD8<sup>+</sup> T lymphocytes to initiate cognate immunity. However, the source of TAAs and immunostimulatory signals for such DCs remains to be elucidated. Here, we demonstrate that 8-MOP plus UVA light reduces melanoma cell viability along with the emission of ICD-associated danger signals including calreticulin (CALR) exposure on the cell surface and secretion of ATP, high mobility group box 1 (HMGB1) and type I interferon (IFN). Consistently, melanoma cells succumbing to 8-MOP plus UVA irradiation are efficiently engulfed by monocytes, ultimately leading to cross-priming of CD8<sup>+</sup> T cells against cancer. Moreover, malignant cells killed by 8-MOP plus UVA irradiation in vitro vaccinate syngeneic immunocompetent mice against living cancer cells of the same type, and such a protection is lost when cancer cells are depleted of calreticulin or HMGB1, as well as in the presence of an ATP-degrading enzyme or antibodies blocking type I IFN receptors. ECP induces bona fide ICD, hence simultaneously providing monocytes with abundant amounts of TAAs and immunostimulatory signals that are sufficient to initiate cognate anticancer immunity.
Analysis of Passive Wake Mixing Techniques Using Time Resolved Digital Particle Image Velocimetry (2008)

Wake mixing is a common flow control technique that can be used in a multitude of applications to disrupt undesired flow structures. A Time Resolved Digital Particle Image Velocimetry (TRDPIV) experiment was performed to analyze the wake mixing properties of flow control approaches in the wake of a flat plate. Triangular winglet-type vortex generators, two lobed trailing edge geometries, and trailing edge blowing are examined and quantitative comparisons of their passive wake mixing properties are compared. The TRDPIV fields were analyzed using the Proper Orthogonal Decomposition as a metric for deducing wake coherency. Results indicate that the airfoil geometry plays a significant role in decreasing wake coherency. Additionally, the eigenmodes of the lobed geometries revealed the greatest differences in the dynamics of the flow between the low and high Reynolds number flows. This suggests these geometries are sensitive to the character of the boundary layer incident on the passive flow control devices.
OHP-032 Emtricitabine and Tenofovir Disoproxil Fumarate in HIV-Naive Patients: A Pharmacoeconomic Study (2013)

<h3>Background</h3> Truvada, a fixed-dose combination of antiretroviral drugs (emtricitabine and tenofovir fumarate) indicated for HIV-1, was the 12th most expensive drug prescribed in Piedmont during 2009–2010, with a growth of 12%. Since July 2011 the School of Hospital Pharmacy in Turin has developed a two-year pharmacoeconomic project regarding high-cost drugs. <h3>Purpose</h3> To provide to the decision-makers with a management tool to evaluate the treatment costs of HIV patients. <h3>Materials and Methods</h3> The legislation and articles in epidemiology and pharmacoeconomic journals were reviewed. Drummond’s Weighted Checklist method was used to evaluate the pharmacoeconomic articles. A Budget Impact model, based only on the drug costs, was built. The treatment-naive population (290) was extrapolated from the incidence data in Piedmont in 2010. The treatment options relied on the US Department of Health and Human Services guidelines and on the pharmacoeconomic studies. The model suggested a combination of Truvada with: i) efavirenz (NNRTI, Sustiva), ii) atazanavir (PI, Reyataz)+ritonavir (PI booster, Norvir); iii) darunavir (PI, Prezista)+ritonavir (PI booster, Norvir). <h3>Results</h3> The daily treatment cost for a treatment-naive patient varies from €21.78 to €30.64, while the annual expenditure varies from €7,949.17 to €11,184.45. The Budget Impact was calculated assuming that the 290 new HIV cases had been treated for one year with one of the therapeutic strategies provided. The variation in comparison with association i) were respectively +24.64% for combination ii) and +40.70% for combination iii). Treatment iii) was the most expensive (€324,3491.37) and increased the annual expenditure by 40.70% (€938,233.23) as compared with treatment i) (€2305,258.14). <h3>Conclusions </h3> The Budget Impact analysis will be used to perform pre-assessments of expenditure in order to set up health care programmes for the allocation of the economic resources. A pharmacoeconomic analysis of cost-effectiveness will be performed between the associations Truvada + Reyataz and Truvada + Sustiva. No conflict of interest.
Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders? (2007)

The common presence of alpha-synuclein aggregates in peripheral autonomic neurons may represent an early presymptomatic phase in the development of Lewy body disorders.
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? (2008)

The oral glucose tolerance test (oGTT) is a common tool to provoke a metabolic challenge for scientific purposes, as well as for diagnostic reasons, to monitor the kinetics of glucose and insulin. Here, we aimed to follow the variety of physiological changes of the whole metabolic pattern in plasma during an oGTT in healthy subjects in a nontargeted reversed-phase ultra performance liquid chromatography coupled to electrospray ionization quadrupole time of flight mass spectrometric metabolomics approach. We detected 11,500 metabolite ion masses/individual. Applying multivariate data analysis, four major groups of metabolites have been detected as the most discriminating oGTT biomarkers: free fatty acids (FFA), acylcarnitines, bile acids, and lysophosphatidylcholines. We found in detail 1) a strong decrease of all saturated and monounsaturated FFA studied during the oGTT; 2) a significant faster decline of palmitoleate (C16:1) and oleate (C18:1) FFA levels than their saturated counterparts; 3) a strong relative increase of polyunsaturated fatty acids in the fatty acid pattern at 120 min; and 4) a clear decrease in plasma C10:0, C12:0, and C14:1 acylcarnitine levels. These data reflect the switch from beta-oxidation to glycolysis and fat storage during the oGTT. Moreover, the bile acids glycocholic acid, glycochenodeoxycholic acid, and glycodeoxycholic acid were highly discriminative, showing a biphasic kinetic with a maximum of a 4.5- to 6-fold increase at 30 min after glucose ingestion, a significant decrease over the next 60 min followed by an increase until the end of the oGTT. Lysophosphatidylcholines were also increased significantly. The findings of our metabolomics study reveal detailed insights in the complex physiological regulation of the metabolism during an oGTT offering novel perspectives of this widely used procedure.
Inhibition of Cuticular Lipid Biosynthesis in Pisum sativum by Thiocarbamates (1974)

Treatment of slices of young pea leaves (Pisum sativum) with muM solutions of alpha-chlorallyl diethyldithiocarbamate, dichloroallyl diisopropylthiocarbamate, or S-ethyldipropylthiocarbamate resulted in inhibition of incorporation of [1-(14)C]acetate into C(31) alkane and C(31) secondary alcohol, very little effect on the synthesis of C(26) and C(28) fatty alcohols, and an accumulation of (14)C in shorter chain cuticular lipids, particularly C(22) acid. Higher concentrations of the thiocarbamates caused inhibition of synthesis of C(26) and C(28) fatty alcohols and an accumulation of label in C(22) acid. Further increase in thiocarbamate concentration resulted in inhibition of C(22) acid synthesis also. The three thiocarbamates at muM concentration also inhibited incorporation of [1-(14)C]stearic acid specifically into C(31) alkane and C(31) secondary alcohol. These results suggest that thiocarbamates reduce cuticular lipid formation by a concentration-dependent inhibition of the various chain-elongating enzyme systems.
Front Matter: Volume 9752 (2016)

This PDF file contains the front matter associated with SPIE Proceedings Volume 9752, including the Title Page, Copyright information, Table of Contents, Introduction (if any), and Conference Committee listing.
Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival (2018)

Serum GP88 levels are significantly different depending on age and GS, and they are associated with the prognosis of PCa patients.
Multiplex Image Projection Using Multi-band Projectors (2013)

In this paper, we propose a novel image representation method by using multi-band projectors. In this image representation method, each observer, such as human, camera and other sensors, can perceive different images from each other, even if the image projected from the projector is identical. For this objective, we encode multiple images into a single image by using the difference of spectral sensitivity of each observer, and project it by using the multi-band projector. The projected image is decoded by observers, such as human retina and CCD sensor, as different images based on their spectral sensitivity. The experimental results show the effectiveness of the new image representation method.
Neuron-targeted electrical modulation (2020)

Engineering neurons to make conductive polymers enables cell type–specific behaviors
972: Clinical, Pathologic, and Molecular Correlations of Necrosis in the Primary Tumor of Patients with Renal Cell Carcinoma (2005)

You have accessJournal of UrologyDiscussed Poster, Tuesday, May 24, 2005, 8:00 am - 12:00 pm1 Apr 2005972: Clinical, Pathologic, and Molecular Correlations of Necrosis in the Primary Tumor of Patients with Renal Cell Carcinoma JohnS Lam, Oleg Shvarts, Jonathan W. Said, Allan J. Pantuck, David B. Seligson, Michael E. Aldridge, Matthew H. Bui, Xueli Liu, Steven Horvath, and Arie S. Belldegrun JohnS LamJohnS Lam More articles by this author , Oleg ShvartsOleg Shvarts More articles by this author , Jonathan W. SaidJonathan W. Said More articles by this author , Allan J. PantuckAllan J. Pantuck More articles by this author , David B. SeligsonDavid B. Seligson More articles by this author , Michael E. AldridgeMichael E. Aldridge More articles by this author , Matthew H. BuiMatthew H. Bui More articles by this author , Xueli LiuXueli Liu More articles by this author , Steven HorvathSteven Horvath More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35128-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "972: Clinical, Pathologic, and Molecular Correlations of Necrosis in the Primary Tumor of Patients with Renal Cell Carcinoma." The Journal of Urology, 173(4S), p. 263 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 263 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information JohnS Lam More articles by this author Oleg Shvarts More articles by this author Jonathan W. Said More articles by this author Allan J. Pantuck More articles by this author David B. Seligson More articles by this author Michael E. Aldridge More articles by this author Matthew H. Bui More articles by this author Xueli Liu More articles by this author Steven Horvath More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF DownloadLoading ...
New self-assembly strategies for next generation lithography (2010)

Future demands of the semiconductor industry call for robust patterning strategies for critical dimensions below twenty nanometers. The self assembly of block copolymers stands out as a promising, potentially lower cost alternative to other technologies such as e-beam or nanoimprint lithography. One approach is to use block copolymers that can be lithographically patterned by incorporating a negative-tone photoresist as the majority (matrix) phase of the block copolymer, paired with photoacid generator and a crosslinker moiety. In this system, poly(&#945;-methylstyrene-block-hydroxystyrene)(P&#945;MS-b-PHOST), the block copolymer is spin-coated as a thin film, processed to a desired microdomain orientation with long-range order, and then photopatterned. Therefore, selfassembly of the block copolymer only occurs in select areas due to the crosslinking of the matrix phase, and the minority phase polymer can be removed to produce a nanoporous template. Using bulk TEM analysis, we demonstrate how the critical dimension of this block copolymer is shown to scale with polymer molecular weight using a simple power law relation. Enthalpic interactions such as hydrogen bonding are used to blend inorganic additives in order to enhance the etch resistance of the PHOST block. We demonstrate how lithographically patternable block copolymers might fit in to future processing strategies to produce etch-resistant self-assembled features at length scales impossible with conventional lithography.
Design of a Power-Electronic-Assisted OLTC for Grid Voltage Regulation (2014)

High penetration of distributed generation (DG) has led to frequent voltage fluctuations in the distribution network. This paper describes the design of a partially rated, power-electronic-assisted onload tap-changing (OLTC) autotransformer. Positive and negative compensation of the grid voltage can be achieved on feeders that have high distributed generation and/or loading. A novel design of taps comprised of several no-load switches and a single semiconductor-mechanical hybrid switch have been proposed, that requires reduced voltage rating and a number of switches. In steady state, the mechanical switch in the hybrid switch conducts the load current resulting in low steady-state losses. During the tap change process, the OLTC uses semiconductor switches, namely insulated-gate bipolar transistor /metal-oxide semiconductor field-effect transistor, thus achieving arc-free tap change and long lifetime of switches. The OLTC system has been customized for both low-voltage and medium-voltage three-phase distribution networks. An open-delta configuration for the medium-voltage application has been proposed that requires only two OLTC units to control all three line voltages. Simulations are carried out to verify the steady-state and transient operation of the proposed OLTC.
Evaluation and Management of Valgus Impacted Four-part Proximal Humerus Fractures (2006)

Therapeutic study, level V (expert opinion). See Guidelines for Authors for a complete description of levels of evidence.
A parallel approach to post source decay MALDI-TOF analysis (2005)

We present a novel enhancement to matrix-assisted laser desorption ionization (MALDI) post-source decay (PSD) analysis whereby fragment ions from multiple precursor ions are acquired into the same spectrum without employing a timed ion gate to preselect each parent ion. Fragment ions are matched to their corresponding precursor ions by comparing spectra acquired at slightly different reflectron electric fields. By measuring the difference in time-of-flight (TOF) between the two spectra for each fragment, it is possible to calculate the mass of the fragment ion and its parent. This new "parallel PSD" technique reduces analysis time and consumes less sample than conventional PSD, which requires an ion gate for serial preselection of precursor ions.
Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity (2018)

Abstract Synthetic peptides derived from naturally occurring host defence peptides (HDPs) have garnered significant attention as novel pharmaceuticals, particularly as alternatives to antibiotics and for immunomodulatory applications. One of the barriers to advancing synthetic peptides for therapeutic applications is their tendency to aggregate under specific ionic conditions similar to those they would encounter in vivo. Formulating peptides with biocompatible excipients that prevent solvent‐induced peptide aggregation represents a possible solution to this aggregation issue; however, this strategy has not been systematically explored. In the present work, we describe the screening of various polymeric substances (including hyaluronic acid, carboxymethyl cellulose and hydroxypropyl methyl cellulose) as formulation candidates for HDPs and identified derivatized hyperbranched polyglycerols (dHPGs) as a biocompatible excipient that limits peptide aggregation. Notably, the immunomodulatory activity of a synthetic innate defence regulator peptide, IDR‐1018, formulated with dHPG was retained when evaluated against both peripheral blood mononuclear cells and human bronchiolar epithelial cells in vitro. Further characterization of dHPG polymers revealed that decreasing the negative charge density on the polymer surface potentiated the cytotoxic effects of IDR‐1018, emphasizing the need to optimize this parameter for future peptide delivery formulations. Importantly, the dHPG formulated IDR‐1018 inhibited peptide aggregation in vitro in the presence of mucin as well as in vivo when injected subcutaneously into CD1 mice. This study highlights the potential use of dHPGs as formulation candidates for synthetic HDPs and identifies important considerations regarding their physico‐chemical properties and relevance to immunomodulatory applications.