gebhart/patrepeval huggingface dataset:
Fluorouracil Therapy of Intraocular Greene Melanoma in the Rabbit (1988)

We evaluated the efficacy of intraocular and periocular fluorouracil treatment in an experimental iris tumor of the rabbit (Greene amelanotic melanoma). Four consecutive intravitreal injections of 1 mg of fluorouracil given twice weekly completely suppressed tumor growth in all treated eyes for six weeks if treatment was initiated 24 hours after tumor implantation. In contrast, all control eyes implanted with an equal number of Greene melanoma cells but treated with intravitreal saline developed massive tumor invasion of the iris within two weeks. Additional subconjunctival therapy following intravitreal therapy for two weeks was only slightly more effective than intravitreal therapy alone. If therapy was delayed for one week, the iris tumors became macroscopically visible and subsequent treatment with intravitreal and subconjunctival fluorouracil was of limited value in suppressing growth.
Peering Through the Haze: Privacy and Monitoring in the Cloud Computing Paradigm. (2020)

Abstract not provided.
Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite (2013)

The findings of arterial hyper-responsiveness to infused NO₂⁻ in CHF patients, with evidence of accelerated transvascular NO₂⁻ clearance (presumably with concomitant NO release) suggests that NO₂⁻ effects may be accentuated in such patients. These findings provide a stimulus for the clinical exploration of NO₂⁻ as a therapeutic modality in CHF.
Synthesis, Characterization, and Reactivity of Chromium Boratabenzene Complexes (2000)

In contrast to the reactivity observed with the isoelectronic cyclopentadienyl salts, the reaction of CrCl3(THF)3 with boratabenzene anions results in the formation of Cr(II) complexes. Thus, addition of Li(C5H5B−Me) to CrCl3(THF)3 in THF gives (C5H5B−Me)2Cr (3). Similarly, Li(C5H5B−NMe2) and CrCl3(THF)3 yield (C5H5B−NMe2)2Cr (4), while Li(C5H5B−Ph) and CrCl3(THF)3 provide (C5H5B−Ph)2Cr (5). Compounds 3−5 were characterized by single-crystal X-ray diffraction studies, and all possess typical sandwich structures. The reaction of borabenzene−ligand adducts with suitable Cr(III) starting materials provides boratabenzene−Cr(III) complexes. Addition of C5H5B−PMe3 (Bb-PMe3) to MeCrCl2(THF)3 in benzene gives (C5H5B−Me)CrCl2(PMe3) (6) in low yield. Treatment of MeCrCl2(THF)3 with the pyridine adduct of borabenzene, C5H5B−NC5H5 (Bb-Py), does not work effectively. The composition of one of the products from this reaction, the binuclear dimer [(C5H5B−Me)CrClMe]2 (7), indicates Me/Cl redistribution processes. Treatment of CrCl3(THF)3 with 3 equivalents MeMgBr in THF, followed by addition of Bb-Py gives (C5H5B−Me)CrMe2(Py) (8). Similarly, Ph3Cr(THF)3 and Bb-Py afford (C5H5B−Ph)CrPh2(Py) (9). Compound 8 with the well-defined activators B(C6F5)3 and [Ph3C][B(C6F5)4] can polymerize ethylene with activities competitive with those of (C5H5B−Me)CrMe2(PMe3)/B(C6F5)3 (2/B(C6F5)3) and Cp*CrMe2(PMe3)/B(C6F5)3. Methylaluminoxane (MAO) can also be used as an activator with the complexes containing a coordinated phosphine. The pyridine counterparts fail to give polymerization catalysts with MAO.
Plate Fixation of Olecranon Osteotomies (2007)

The management of intra-articular distal humeral fractures remains a difficult surgical problem. Although an olecranon osteotomy provides excellent exposure for management of these fractures, a number of complications can occur after the creation and repair of the osteotomy including nonunion, malunion, hardware failure, and pain secondary to prominent hardware. In an effort to reduce the incidence of these complications, the senior authors now use contoured 3.5 mm reconstruction plates for the fixation of their apex-distal chevron olecranon osteotomies. Two surgeons at a single institution used this technique of exposure on a series of 17 consecutive patients with intra-articular distal humerus fractures between 1996 and 1999. In this series, all osteotomies united. There was one complication related specifically to the osteotomy: one of the screws in the plate penetrated the proximal radioulnar joint, interfering with forearm rotation; a second procedure was required to shorten the screw. Only one of the 17 patients requested plate removal during the 32 month (average) follow-up period. Plate fixation of olecranon osteotomies using a 3.5 mm reconstruction plate provides a construct with predictable healing and few complications. The overall results using this technique are comparable with other reported methods in the literature.
The Microvenous Valvular Anatomy of the Human Dorsal Thoracic Fascia (1997)

The use of free scapular fasciocutaneous flaps for reconstruction of recalcitrant grade 6 venous stasis ulcers has shown excellent early success rates. Venous refilling times measured postoperatively over the flaps by photoplethysmography have noted improvements to normal levels. Preliminary anatomic studies have demonstrated valves in the circumflex scapular veins of flaps used in reconstruction. The purpose of this study was to investigate and document the number, morphology, size, and location of valves in the human dorsal thoracic fascia. Ten scapular flaps were obtained from unembalmed cadavers and injected with methyl methacrylate. Each flap cast was divided into four parts: proximal, right and left, and distal, right and left. We reduced the size of specimens (the largest being 24 x 11 mm) and studied them in a scanning electron microscope. We identified all valves, estimated the diameter of the corresponding vein, calculated the depth of the valvular sinus, and related it to the corresponding venous size. Light microscopy and transmission electron microscopy were used as assisting tools applied to glutaraldehyde-fixed specimens. Analysis of injected specimens showed that valves were most abundant in veins with a luminal diameter of 30 to 120 microns (59.3 percent of 905 valves). The depth of valves became larger with increasing venous diameter. The sizes of valve sinuses were not different for individual valves. Except for veins larger than 1000 microns in diameter, there was no significant difference between the number of valves in different parts of an individual flap, nor were there significant differences between the valve numbers in different flaps. Most valves were bicuspid; only in the vein category of 30 to 120 microns were unicuspid valves encountered. Valves sometimes were located in series in a short segment of a vein; occasionally, they were found at the merging site of two veins. Transmission electron microscopy showed that valve leaflets had collagen fibers that ascended toward the tip of the leaflet and occasionally were accompanied by elastic fibers. Myofibroblasts were regularly present in the valve leaflets. These data show that fasciocutaneous flaps from the scapular region have numerous valves (90 valves on average in each flap) in the venous microcirculation. The microvenous valves in the dorsal thoracic fascia appear to be structurally similar to valves in larger veins. These valves may play a role in the improved hemodynamics and promising clinical outcome of patients with chronic venous insufficiency who have undergone free scapular flap reconstruction.
Small Molecule-Induced Intramolecular Electron “Pitch and Catch” in a RhodiumI Complex with Substitutionally Inert Redox-Active Ligands (1999)

Chemically or electrochemically induced uptake and release of small molecules “L” by [RhI{Fe(C5H5)(C5H4SCH2CH2PPh2)}2]BF4 occurs via ferrocenyl group-centered oxidation/reduction to form [RhIII{Fe(C5H5)(C5H4SCH2CH2PPh2)}2(L)2][BF4]3. This reaction occurs via a novel intramolecular electron “pitch and catch” process involving the Fe and Rh centers.
Intra-pulse difference-frequency generation of mid-infrared (27–20  μm) by random quasi-phase-matching (2019)

We present a mid-infrared (MIR) source based on intra-pulse difference-frequency generation under the random quasi-phase-matching condition. The scheme enables the use of non-birefringent materials whose crystal orientations are not perfectly and periodically poled, widening the choice of media for nonlinear frequency conversion. With a 2 μm driving source based on a Ho:YAG thin-disk laser, together with a polycrystalline ZnSe element, an octave-spanning MIR continuum (2.7-20 μm) was generated. At over 20 mW, the average power is comparable to regular phase-matching in birefringent crystals. A 1 μm laser system based on a Yb:YAG thin-disk laser was also tested as a driving source in this scheme. The new approach provides a simplified way for generating coherent MIR radiation with an ultrabroad bandwidth at reasonable efficiency.
A statistical thermodynamic derivation of the ballistic model for vacancy migration (1991)

Abstract A statistical thermodynamic derivation of the enthalpy and entropy associated with vacancy migration by nearest-neighbour hopping is presented. The derivation is in accordance with the ballistic model hypothesis that the migration energy is kinetic in origin for vacancy nearest-neighbour hopping. It is shown that the general form of the enthalpy and entropy of migration is qualitatively similar to, but not identical with that given previously. Except at a very high temperature or when the Debye temperature is very large, the correction of the migration enthalpy arising from the statistical thermodynamic derivation is of negligible importance. The entropy correction is, however, significant and must be employed in order to obtain agreement with experimental values of the migrational entropy for elemental metals known to diffuse by nearest-neighbour vacancy migration.
Geomagnetic Referencing in the Arctic Environment (2011)

Abstract Geomagnetic referencing is becoming an increasingly attractive alternative to north-seeking gyroscopic surveys to achieve the precise wellbore positioning essential for success in today's complex drilling programs. However, the greater magnitude of variations in the geomagnetic environment at higher latitudes makes the application of geomagnetic referencing in those areas more challenging. Precise, real-time data on those variations from relatively nearby magnetic observatories can be crucial to achieving the required accuracy, but constructing and operating an observatory in these often harsh environments poses a number of significant challenges. Operational since March 2010, the Deadhorse Magnetic Observatory (DED), located in Deadhorse, Alaska, was created through collaboration between the United States Geological Survey (USGS) and a leading oilfield services supply company. DED was designed to produce real-time geomagnetic data at the required level of accuracy, and to do so reliably under the extreme temperatures and harsh weather conditions often experienced in the area. The observatory will serve a number of key scientific communities as well as the oilfield drilling industry, and has already played a vital role in the success of several commercial ventures in the area, providing essential, accurate data while offering significant cost and time savings, compared with traditional surveying techniques.
Inorganic Organic Hybrid Porous Silica for Fuel Cell Technology (2011)

30 mol% HS/SO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> H containing inorganic organic Hybrid Porous Silica (HO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> S-HPS) and polymer polyvinyledenefluoride-hexafluropropene (PVDF-HFP) was mixed together to produce 10 to 150 thick membrane (SO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> H-HPS-PVDF-HFP). Proton conductivity of resultant HO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> S-HPS before and after mixing with PVDF-HFP determined in dry nitrogen and 100% relative humidity (RH) using impedance spectroscopy. 30 mol% SO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> H-HPS-PVDF-HFP shows proton conductivity ca. 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> S/cm. Nafion117 also shows proton conductivity 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> S/cm at 25 °C and 100% relative humidity. Membrane electrode assembly (MEA) was developed and used in direct methanol fuel cell technology. 64 mW/cm" power density of the MEA using single cell was observed at 80 °C. Materials were characterized using various instrumental techniques, such as ICP, XRD, TG-DTA, XPS, N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> sorption, <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">29</sup> Si and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> C MAS NMR, FT-IR and particle size analyzer.
Performance of adaptive modulation with transmit diversity over frequency-selective Rayleigh fading channels (2002)

Under the CDMA concept, the average bit error rate and the average throughput for adaptive modulation/transmit diversity combined schemes are derived over frequency-selective Rayleigh fading channels. Two transmit diversity schemes are considered for analysis: space-time transmit diversity and selection transmit diversity.
Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 (2021)

Persistence of Antibody after mRNA-1273 Vaccination A total of 33 participants who received both doses of the Moderna mRNA-1273 vaccine against SARS-CoV-2 had blood drawn over a period of 6 months ...
Powering flexible manufacturing systems with intelligent contact-less power transfer (2008)

Flexible manufacturing systems (FMS) and reconfigurable manufacturing systems (RMS) have both recently evolved to meet increasing demands for flexible manufacturing. This paper investigates the possibility of contact-less power and wireless data transfer to increase the flexibility and safety of various FMS modules by eliminating the need for power or data connections. The paper discusses advantages and implementation aspects of the proposed inductive power transfer (IPT) system and feasibility tests are undertaken to ensure the compatibility of IPT and the FMS modules, which form part of a lab-size modular test bed. In order to increase the cost effectiveness of the design, each module will run for an eight hour shift using a battery which is then automatically recharged via IPT. An energy aware custom switch mode charger has been designed and tested. A greedy heuristic (IEC 61499 compliant) scheduler is implemented to optimize the production schedule based on the level of charge. Design requirements for the charger, energy monitor and scheduler are discussed followed by performance results. The IPT system has been specified however it is still to be incorporated in to the final system.
Webrb (2007)

Many web-applications can be characterized as relational. In this paper we introduce and evaluate WebRB, a visualdomain-specific language for building such applications. WebRB addresses the limitations of the conventional imperative-embedding approach typically used to build relational web-applications. We describe the WebRB language, present extended examples of its use, and discuss the WebRB visual editor, libraries, and runtime. We then evaluate WebRB by comparing it to alternative approaches, and demonstrate its effectiveness in building relational web-applications.
Dielectric Function of Polycrystalline SiC from 190 nm to 15 ?m (1999)

We have studied polycrystalline SiC using spectroscopic ellipsometry (from the mid-IR to the quartz-UV), X-ray diffraction, and Raman scattering. In the UV, the pseudodielectric function is affected by surface roughness, and the E1 peak is broadened due to the finite grain size. X-ray rocking curves indicate a preferred orientation with the hexagonal axis along the surface normal and a mosaic spread of 3.5°. FTIR ellipsometry shows a reststrahlen band due to phonon absorption and a strong anistropy peak near the zero crossing of the extraordinary dielectric function at its LO energy. The Raman phonon energies agree with the FTIR results. The Raman data also show the effects of finite grain size and stacking disorder. We conclude that the poly-SiC wafer is anisotropic, but does not have a well-defined polytype (such as 6H or 4H).
An Attempt to Adapt Superacid Chemistry for “Living” Carbenium Ion Polymerizations (1974)

Abstract The discovery that carbocations can be stabilized in super acid media, e.g., SbF5-SO2, etc., raises the possibility of "living" carbenium ion polymerization. Polymerization experiments with isobutylene and styrene carried out at high acid concentrations and in the virtual absence of nucleophile, i.e., under conditions conducive for living polymerization, failed to indicate a linear conversion vs molecular weight relationship and/or block copolymer formation. Additional model experiments with 2,4,4-trimethyl-1-pentene substantiate our conclusions that "living" carbocation polymerizations are unlikely to be produced by superacid chemistry.
Development of Stilbenoid and Chalconoid Analogues as Potent Tyrosinase Modulators and Antioxidant Agents (2022)

A number of stilbenoid and chalconoid derivatives were prepared by straightforward methods, and their ability to modulate tyrosinase activity and to scavenge free radicals were evaluated in vitro. The cell-free in vitro evaluation revealed two diarylpropanes, <b>24</b> and <b>25</b>, as potent tyrosinase inhibitors, whereas diarylpropenoic acids seemed to enhance the enzymatic activity. An in silico evaluation of the binding affinity of the selected compounds with the crystal structure of tyrosinase was also conducted in order to obtain better insight into the mechanism. Representative synthetic compounds with inhibitory and activating properties were further evaluated in melanoma cell lines B16F1 and B16F10 for their ability to moderate tyrosinase activity and affect melanin production. Dihydrostilbene analogues <b>I</b> and <b>II</b>, exhibited a stronger anti-melanogenic effect than kojic acid through the inhibition of cellular tyrosinase activity and melanin formation, while diarylpropanoic acid <b>44</b> proved to be a potent melanogenic factor, inducing cellular tyrosinase activity and melanin formation. Moreover, the antioxidant evaluation disclosed two analogues (<b>29</b> and <b>11</b>) with significant free-radical-scavenging activity (12.4 and 20.3 μM), which were 10- and 6-fold more potent than ascorbic acid (122.1 μΜ), respectively.
Supplementary Figures 1-7 from <i>Enterococcus faecalis</i> Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect (2023)

Supplementary Figures 1-7 from &lt;i&gt;Enterococcus faecalis&lt;/i&gt; Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect
MRI Volumetric Analysis of the Hypothalamus and Limbic System across the Pediatric Age Span (2023)

This study provides unique age- and sex-specific volumes of the components of the limbic system throughout the pediatric age range to serve as normal values in comparative studies. Quantification of volumetric abnormalities of the limbic system on brain MRI may offer insights into phenotypical variations of diseases and may help elucidate new pathological phenotypes.
Type III secretion chaperones ShcS1 and ShcO1 from Pseudomonas syringae pv. tomato DC3000 bind more than one effector (2005)

The hrp-type III secretion (TTS) system is a key pathogenicity factor of the plant pathogen Pseudomonas syringae pv. tomato DC3000 that translocates effector proteins into the cytosol of the eukaryotic host cell. The translocation of a subset of effectors is dependent on specific chaperones. In this study an operon encoding a TTS chaperone (ShcS1) and the truncated effector HopS1' was characterized. Yeast two-hybrid analysis and pull-down assays demonstrated that these proteins interact. Using protein fusions to AvrRpt2 it was shown that ShcS1 facilitates the translocation of HopS1', suggesting that ShcS1 is a TTS chaperone for HopS1' and that amino acids 1 to 118 of HopS1' are required for translocation. P. syringae pv. tomato DC3000 carries two shcS1 homologues, shcO1 and shcS2, which are located in different operons, and both operons include additional putative effector genes. Transcomplementation experiments showed that ShcS1 and ShcO1, but not ShcS2, can facilitate the translocation of HopS1' :: AvrRpt2. To characterize the specificities of the putative chaperones, yeast two-hybrid interaction studies were performed between the three chaperones and putative target effectors. These experiments showed that both ShcS1 and ShcO1 bind to two different effectors, HopS1' and HopO1-1, that share only 16% amino acid sequence identity. Using gel filtration it was shown that ShcS1 forms homodimers, and this was confirmed by yeast two-hybrid experiments. In addition, ShcS1 is also able to form heterodimers with ShcO1. These data demonstrate that ShcS1 and ShcO1 are exceptional class IA TTS chaperones because they can bind more than one target effector.
Purification and Cloning of Type A/B hnRNP Proteins Involved in Transcriptional Activation from the Rat spi 2 Gene GAGA Box (2000)

The GAGA box of the rat serine protease inhibitor 2 (spi 2) genes not only acts as a basal promoter element, but also mediates transcriptional activation by growth hormone and interleukin-6. The GAGA box is separated from the TATA box by only 12 bp, and this close association is required for efficient transcription. Hence, the GAGA box may influence transcription efficiency through interactions between GAGA box binding proteins and some components of the RNA polymerase II complex. Here we report the cloning of two GAGA box-binding proteins termed p38 and p40, that belong to the type A/B heterogeneous nuclear ribonucleoprotein subgroup. GAGA box mutations that diminish the affinity for p38 and p40 decrease basal and GH-induced reporter gene expression. Furthermore, nuclear extracts depleted of p38 and p40 can no longer support GAGA box-dependent in vitro transcription. Therefore, two polypeptides previously assigned to a family of RNA processing proteins also act as DNA-binding, promoter-specific transcription factors.