gebhart/patrepeval huggingface dataset:
Ameloblastin expression in rat incisors and human tooth germs (1996)

We recently identified ameloblastin as an ameloblast-specific gene product from a rat incisor cDNA library (Krebsbach et al., J. Biol. Chem. 271: 4431-4435, 1996). Here we report the developmental pattern of expression of ameloblastin in rat incisors and human tooth germs as visualized by in situ hybridization and immunochemistry. Compared to the expression of amelogenin, the major ameloblast product, ameloblastin mRNA was more widely expressed in ameloblasts from the presecretory to the late maturation stage of development. Ameloblastin mRNA was first observed in the juxtanuclear cytoplasm or presecretory stage ameloblasts, gradually increased in the distal cytoplasm of secretory stage ameloblasts and was found throughout the cytoplasm of early to late maturation stage ameloblasts. The immunostaining of ameloblastin, using a monospecific antibody raised against a recombinant protein, showed intense reactivity in Tomes' processes of secretory stage ameloblasts and surrounding enamel. The immunoreaction was concentrated in the juxtanuclear cytoplasm of late maturation stage ameloblasts. High-resolution colloidal gold immunocytochemistry established the presence of ameloblastin antigenicity in the Golgi apparatus, secretory granules in Tomes' process and enamel. Human tooth germs in early to late bell stage also expressed ameloblastin mRNA and ameloblastin antigenicity in the ameloblasts. Western blot analysis of protein extracts from rat incisor tissues indicated that ameloblastin can be found in the enamel epithelial tissue and in mineralized enamel, as well as in the EDTA decalcification solution. These data indicate that ameloblastin is an ameloblast secretory product which is sequentially expressed from the presecretory to the late maturation stage in rat and human teeth. This unique developmental pattern suggests that ameloblastin may have a broader role in amelogenesis than amelogenin and tuftelin.
A position detection sensor for 3-D measurement (2000)

In this paper, a position detection sensor for 3-D measurement is presented. The sensor is designed for detecting positions of laser spots projected on target objects quickly. The sensor has a 256×256 pixel array, a set of address decoders for variable block access and a variable block logical-OR circuit on an 8.9mm × 8.9mm die. The sensor is designed and fabricated in 0.6 µm 3-Metal 2-Poly-Si CMOS process. By the result of measurements using fabricated chips, the accuracy of the 3-D measurement is 0.4%. The speed of 3-D measurement is up to 10000points/sec.
Establishment, characterization and drug sensitivity of four new human soft tissue sarcoma cell lines (1996)

Four new cell lines were established from patients with soft tissue sarcomas. Drug sensitivity as well as genotypic characterization, which may be related to drug sensitivity in these cell lines, was determined. Karyotype, H-ras, c-myc and mutant p53 gene expression, Rb, G1- and S-phase cyclins, E2F and major cyclin/CDK inhibitors such as p16 and p21 and p-glycoprotein were analyzed using cytogenetic, Northern blot and immunological methods. Drug sensitivity was determined using growth inhibition tests. These cell lines differed in their morphology and growth rates, forming colonies in soft agar with a cloning efficiency of 4.3-13.4%, and 3 of the 4 cell lines grew in nude mice. Cytogenetic analysis of cell lines revealed highly aneuploid karyotypes. Deletion and/or translocation of chromosome 17 was seen in HS-16, HS-18 and HS-30 cells, and both copies of chromosome 13 were lost or re-arranged in the HS-18 cell line. Mutant p53 protein was present in all 4 cell lines. HS-18 cells showed no expression of the Rb protein and high levels of expression of E2F, cyclin A, cyclin E and CDK2. HS-16 expressed a higher level of cyclin D than the other 3 cell lines. p21WAF1 expression was seen in all cell lines, but p16ink4 was expressed only in HS-30 and HS-42 cell lines. These cell lines were sensitive to taxol and relatively resistant to methotrexate, vinblastine and 5-fluorouracil when compared with the fibrosarcoma cell line HT-1080. These new cell lines should provide a useful model for the study of soft tissue sarcomas and for evaluating new drugs or treatments.
Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points (2017)

Exposure to pesticides has been associated with neurodevelopmental toxicity. Usually people are exposed to mixtures of pesticides. However, most studies analyze the effects of individual pesticides. Developmental exposure to mixtures of pesticides may result in additive effects or in antagonistic or synergistic effects. The aim of this work was to compare the effects of developmental exposure of rats to cypermethrin or endosulfan with the effects of its mixture on cognitive and motor function and on some underlying mechanisms. Exposure to individual pesticides or the mixture was from gestational day 7 to postnatal day 21. We analyzed the effects, in males and females, on spatial learning and memory, associative learning, anxiety, motor coordination, and spontaneous motor activity. We also analyzed neuroinflammation and NMDA receptor subunits in hippocampus and extracellular GABA in cerebellum. Exposure to the mixture, but not to individual pesticides, impaired spatial memory in males, associative learning in females, and increased motor activity in males and females. This indicates a synergistic effect of cypermethrin and endolsufan exposure on these end points. In contrast, motor coordination was impaired by individual exposure to endosulfan or cypermethrin, associated with increased extracellular GABA in cerebellum, but these effects were prevented in rats exposed to the mixture, indicating an antagonistic effect of cypermethrin and endolsufan exposure on these end points. The results show different interaction modes (synergism or antagonism) of the pesticides, depending on the end point analyzed and the sex of the rats.
A Novel Approach to Unknown Virus Identification in Clinical Samples. (2019)

Abstract not provided.
Synthesis of hierarchically ordered dye-functionalised mesoporous silica with macroporous architecture by dual templating (2000)

Mesostructured silica functionalised with the dye moiety, (2,4-dinitrophenylamine), has been prepared with bimodal pore size distribution. Co-condensation of tetraethoxysilane and 3-(2,4-dinitrophenylamino)propyltriethoxysilane was used to covalently couple the organic chromophore into the wall structure of a silica mesophase formed by surfactant templating. This process was spatially patterned at the macroscale by confining the evaporation-induced precipitation within the regular voids of a colloidal crystal comprising 140 nm-sized polystyrene spheres. Post-synthetic removal of the latex and surfactant templates produced a hierarchically ordered organo-functionalised silica phase.
A “crab-like” 12-cavity relativistic magnetron with diffraction output driven by a transparent cathode (2019)

We present computer simulations of a “crablike” 12 resonator cavity relativistic magnetron with diffraction output (MDO) designed by doubling the number of cavities from our earlier 6 resonator cavity crablike MDO. This work aims to design a compact high-power narrowband microwave source with frequency switching capabilities. UNIPIC particle-in-cell computer simulations show that the crablike 12-cavity MDO with a transparent cathode radiates the TE11 mode with output power 1 GW and electronic efficiency as high as 41% when powered using a 400 kV voltage pulse and 0.41 T magnetic field. Computer simulations also demonstrate that the crablike 12-cavity MDO can radiate different modes, such as the TE21 mode, the TE31 mode, the TE41 mode, and the TE51 mode. The TE21 mode, in particular, can be radiated at three different frequencies, as low as 2.12 GHz, a median operating frequency of 2.4 GHz, and a higher operating frequency of 2.91 GHz, when different magnetic fields are used.
Design of Functional Nucleic Acid Systems for Biomolecular Analysis (2011)

Abstract With the aim of realizing an in situ nucleic acid analysis, we have developed functional nucleic acid probes that can autonomously detect and analyze nucleic acid sequences of interest. Fluorophore-labeled artificial oligonucleotide probes with target-dependent self-ligation or self-digestion functionalities can be used to sense nucleic acids in solution, on solid supports, or even in cells. In addition, we have successfully established a new sensing system using nonmodified nucleic acids as a probe. These probes and sensors are all composed of nonmodified natural-type nucleic acids, and thus can be transcribed directly from dsDNA, giving a high potency for in situ or in-cell application.
Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome (2012)

These findings reveal a broad spectrum of fitness costs to CTL escape mutations in T/F viral genomes, similar to recent findings reported for neutralizing antibody escape mutations, and highlight the extraordinary plasticity and adaptive potential of the HIV-1 genome. Analysis of T/F genomes and their evolved progeny is a powerful approach for assessing the impact of composite mutational events on viral fitness.
ChemInform Abstract: Adsorption of the Trimethylamine Adduct of Aluminum Hydride on Silicon Oxide. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improving server application performance via pure TCP ACK receive optimization (2013)

Network stack performance is critical to server scala-bility and user-perceived application experience. Per-packet overhead is a major bottleneck in scaling network I/O. While much effort is expended on reducing per-packet overhead for data-carrying packets, small control packets such as pure TCP ACKs have received relatively scarce attention. In this paper, we show that ACK receive processing can consume up to 20 % cycles in server appli-cations. We propose a simple kernel-level optimization which reduces this overhead through fewer memory allo-cations and a simplified code path. Using this technique, we demonstrate cycles savings of 15 % in a Web applica-tion, and 33 % throughput improvement in reliable mul-ticast. 1
The Performance Evaluation of Developed Apparatus for Observing the Nanoparticles Phenomena During CMP Process by Applying Evanescent Field (2019)

In this paper, the performance evaluation of developed in-situ apparatus for real-time observation were studied. The apparatus could observe the nanoparticles phenomena on surface between substrate and polishing pad that is essential to improve the Material Removal Rate (MRR) of the substrate during Chemical Mechanical Polishing (CMP) process. We propose the single wavelength by applying an evanescent field in order to observe the nanoparticles phenomena. The experimental condition were separated into two experiments, as different size (sub 10 nm and 105 nm) silica slurry ( 5 wt% with pH 10.5) with pure water (pH 10.5). According to the experimental result, the our apparatus could detect the scattering light intensity of pure water and silica slurry during polishing process. The silica slurry are higher scattering light intensity than pure water, and sub 10 nm silica slurry is highest intensity.
Study of the production of charged pions, kaons, and protons in pPb collisions at $$\sqrt{s_{NN}} =\; $$ s N N = 5.02 $$\,\text {TeV}$$ TeV (2014)

Spectra of identified charged hadrons are measured in pPb collisions with the CMS detector at the LHC at [Formula: see text]. Charged pions, kaons, and protons in the transverse-momentum range [Formula: see text]-1.7[Formula: see text] and laboratory rapidity [Formula: see text] are identified via their energy loss in the silicon tracker. The average [Formula: see text] increases with particle mass and the charged multiplicity of the event. The increase of the average [Formula: see text] with charged multiplicity is greater for heavier hadrons. Comparisons to Monte Carlo event generators reveal that Epos Lhc, which incorporates additional hydrodynamic evolution of the created system, is able to reproduce most of the data features, unlike Hijing and Ampt. The [Formula: see text] spectra and integrated yields are also compared to those measured in pp and PbPb collisions at various energies. The average transverse momentum and particle ratio measurements indicate that particle production at LHC energies is strongly correlated with event particle multiplicity.
Effect of membrane phospholipid compositional changes on adenylate cyclase in LM cells (1978)

Adenylate cyclase activities were examined in mouse LM cell membranes which had been supplemented with polar head groups and/or fatty acids. Basal, fluoride-, and PGE1-stimulated activities varied systematically with changes in phospholipid composition, and PGE1-stimulated activities correlated with the average degree of unsaturation of the phospholipid fatty acids or with the primary amino group character of the phospholipid polar head groups. In addition, the Km for ATP of basal adenylate cyclase was systematically changed by both polar head group and fatty acid supplementation. Alteration of the membrane lipid composition also changed the temperature dependence of the enzyme and the lag time between addition of PGE1 and the onset of a change in catalytic rate. However, none of the alterations in the enzyme activity could be correlated with the viscosities of supplemented membranes and, instead, seemed to be characteristic for a specific polar head group or fatty acid composition. The data suggest a specific interaction of the enzyme with phospholipids and indicate that structural features of phospholipids may play a role in regulating adenylate cyclase activity. It is proposed that adenylate cyclase can exist in several different conformations in the membrane depending upon the phospholipid composition.
Integration of Ceramic Catalyst on Micro-Hotplate of Thermoelectric Hydrogen Sensor (2006)

To integrate the ceramic Pt/alumina catalyst on micro-hotplate of micro-thermoelectric hydrogen sensor (micro-THS), a dispenser technique was used in this study. This micro-THS with the Pt/alumina catalyst is capable of sensing wide range hydrogen concentration of 50 ppm to 3 % at room temperature. For hydrogen/air mixture gas of 50 ppm, voltage signal is measured to be 0.03 mV at room temperature.
Grid Converter Control for WTS (2010)

This chapter contains sections titled: Introduction Model of the Converter AC Voltage and DC Voltage Control Voltage Oriented Control and Direct Power Control Stand-alone, Micro-grid, Droop Control and Grid Supporting Summary References
Supplementary Figure Legend from Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells (2023)

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Direct experimental visualization of the global Hamiltonian progression of two-dimensional Lagrangian flow topologies from integrable to chaotic state (2015)

Countless theoretical/numerical studies on transport and mixing in two-dimensional (2D) unsteady flows lean on the assumption that Hamiltonian mechanisms govern the Lagrangian dynamics of passive tracers. However, experimental studies specifically investigating said mechanisms are rare. Moreover, they typically concern local behavior in specific states (usually far away from the integrable state) and generally expose this indirectly by dye visualization. Laboratory experiments explicitly addressing the global Hamiltonian progression of the Lagrangian flow topology entirely from integrable to chaotic state, i.e., the fundamental route to efficient transport by chaotic advection, appear non-existent. This motivates our study on experimental visualization of this progression by direct measurement of Poincaré sections of passive tracer particles in a representative 2D time-periodic flow. This admits (i) accurate replication of the experimental initial conditions, facilitating true one-to-one comparison of simulated and measured behavior, and (ii) direct experimental investigation of the ensuing Lagrangian dynamics. The analysis reveals a close agreement between computations and observations and thus experimentally validates the full global Hamiltonian progression at a great level of detail.
Noninvasive Activity‐based Control of an Implantable Rotary Blood Pump: Comparative Software Simulation Study (2010)

A control algorithm for an implantable centrifugal rotary blood pump (RBP) based on a noninvasive indicator of the implant recipient's activity level has been proposed and evaluated in a software simulation environment. An activity level index (ALI)-derived from a noninvasive estimate of heart rate and the output of a triaxial accelerometer-forms the noninvasive indicator of metabolic energy expenditure. Pump speed is then varied linearly according to the ALI within a defined range. This ALI-based control module operates within a hierarchical multiobjective framework, which imposes several constraints on the operating region, such as minimum flow and minimum speed amplitude thresholds. Three class IV heart failure (HF) cases of varying severity were simulated under rest and exercise conditions, and a comparison with other popular RBP control strategies was performed. Pump flow increases of 2.54, 1.94, and 1.15 L/min were achieved for the three HF cases, from rest to exercise. Compared with constant speed control, this represents a relative flow change of 30.3, 19.8, and -15.4%, respectively. Simulations of the proposed control algorithm exhibited the effective intervention of each constraint, resulting in an improved flow response and the maintenance of a safe operating condition, compared with other control modes.
The Effects of Ring Size and Substituents on the Rates of Acid‐Catalysed Hydrolysis of Five‐ and Six‐Membered Ring Cyclic Ketone Acetals (2007)

Abstract A series of sterically similar five‐ and six‐membered ring cyclic diol‐derived ketone acetals have been prepared and their rates of acid‐catalysed hydrolysis examined. The rates of hydrolysis are substantially affected by acetal ring conformational stereoelectronic effects and resonance effects depending upon the substituents on the parent ketone; an A1 mechanism of hydrolysis explains the observed effects.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)
Quantum and statistical mechanical studies of liquids. 3. Deriving intermolecular potential functions for the water dimer from ab initio calculations (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantum and statistical mechanical studies of liquids. 3. Deriving intermolecular potential functions for the water dimer from ab initio calculationsWilliam L. JorgensenCite this: J. Am. Chem. Soc. 1979, 101, 8, 2011–2016Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ja00502a014https://doi.org/10.1021/ja00502a014research-articleACS PublicationsRequest reuse permissionsArticle Views303Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Setting a national consensus for managing mild and blast traumatic brain injury: post-meeting consensus report (2020)

A meeting was held on Wednesday 15 January 2020 to examine the current evidence for non-routine imaging and for neuroendocrine screening in the management of military personnel with brain injury and overlapping symptom domains. The Summit aimed to specifically address the relative utility of magnetoencephalography (MEG), diffusion tensor imaging (DTI) and susceptibility weighted imaging (SWI) in the UK context. This Consensus Report discusses points of consensus, points for further discussion/points of equipoise and recommendations that arose during, and following, the meeting.
Quaternary Ammonium Ionic Liquid Electrolyte for a Silicon Nanowire-Based Lithium Ion Battery (2011)

The performance of a silicon nanowire battery anode was investigated in electrolytes consisting of butyl-trimethyl ammonium bis(trifluoromethylsulfonyl)imide (QATFSI) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). The lithiation capacity of silicon nanowires in 1 M LiTFSI/QATFSI was low due to the lack of a stable solid–electrolyte interface (SEI) layer. The addition of 10 wt % propylene carbonate to the ionic liquid electrolyte promoted the formation of a stable SEI layer and resulted in substantially higher lithiation capacity. Galvanostatic cycling at a rate of C/20 for silicon half-cells and Si/LiCoO2 full cells showed good performance with a discharge capacity of ∼2000 mAh/g and Coulombic efficiency of 97% after 50 cycles. The effect of electrolyte additives, including ethylene carbonate and vinylene carbonate, was investigated by chronopotentiometry and electrochemical impedance spectroscopy. Results are discussed in terms of the SEI layer and its influence on battery capacity as well as cycle life.
Momentum and Thermal Boundary Layer Development on an Internally Cooled Turbine Vane (2012)

Recent advances in computing power have made conjugate heat transfer simulations of turbine components increasingly popular; however, limited experimental data exist with which to evaluate these simulations. The primary parameter used to evaluate simulations is often the external surface temperature distribution, or overall effectiveness. In this paper, the overlying momentum and thermal boundary layers at various streamwise positions around a conducting, internally cooled simulated turbine vane were measured under low (Tu = 0.5%) and high (Tu = 20%) freestream turbulence conditions. Furthermore, experimental results were compared to computational predictions. In regions where a favorable pressure gradient existed, the thermal boundary layer was found to be significantly thicker than the accompanying momentum boundary layer. Elevated freestream turbulence had the effect of thickening the thermal boundary layer much more effectively than the momentum boundary layer over the entire vane. These data are valuable in understanding the conjugate heat transfer effects on the vane as well as serving as a tool for computational code evaluation.