gebhart/patrepeval huggingface dataset:
384 Jessner-kanoff Lymphocytic Infiltrate as a Side Effect of Immunotherapy (2012)

BACKGROUND: Allergen immunotherapy has been used in the management of allergic diseases for nearly 100 years. It is the only specific treatment for hymenoptera venom anaphylaxis. Various venom immunotherapy schedules have been designed to treat anaphylaxis. Although the effect of venom immunotherapy is well documented, there is also an increased risk of side-effects in bee-venom-treated patients and in those with rapid dose increase. METHODS: This report describes the first case of a patient in the literature with Jessner's Lymphocytic infiltration as a side effect of venom immunotherapy. This is a chronic, benign, T cell pseudolymphoma characterized by the occurrence of recurrent, asymptomatic, smooth, erythematous, non-scaling papules or plaques. However, the exact cause of Jessner's Lymphocytic Infiltration is unknown. RESULTS: The case here reported was a 61 year-old male pediatrician, who has been followed by at our Immunology Service because of an immediate allergy to a bee sting managed with venom immunotherapy. His chief complaint was an anaphylactic reaction after 5 minutes of a bee sting. The onset of his symptoms was gradual and began just 25 minutes after the sting. The venom immunotherapy regimen was planned and the protocol immediately began without premedication. But during the initial phases of treatment, on the third dose of immunotherapy, he reported severe itching. After complaining of itching, many erythematous papules and plaques on his chest were developed. The lesions flared up for 3 days period just after injection and decreased afterwards. The type of lesions and their location supported the diagnosis of Jessner disease, which had also a histopathological confirmation. CONCLUSIONS: We herein report this case to call attention to this side effect of VIT that there may be more similar cases never reported.
Recovery of intrinsic fluorescence from single‐point interstitial measurements for quantification of doxorubicin concentration (2013)

This method will allow for the determination of local concentrations of fluorescent drugs, such as doxorubicin, from minimally invasive fluorescence measurements. This is particularly interesting in the context of transarterial chemoembolization (TACE) treatment of liver cancer.
Nucleation and growth of Pt atomic layer deposition on Al2O3 substrates using (methylcyclopentadienyl)-trimethyl platinum and O2 plasma (2011)

The nucleation and growth of Pt atomic layer deposition (ALD) on Al2O3 substrates was studied using (methylcyclopentadienyl)-trimethyl platinum (MeCpPtMe3) and O2 plasma as the reactants. The nucleation of Pt ALD was examined on Al2O3 ALD substrates at 300 °C using a variety of techniques including spectroscopic ellipsometry, x-ray reflectivity, x-ray photoelectron spectroscopy, and scanning electron microscopy. These techniques revealed that Pt ALD does not nucleate and grow immediately on the Al2O3 ALD substrates. There was negligible Pt ALD during the first 38 ALD cycles. The Pt ALD growth rate then increased substantially during the next 12 ALD cycles. Subsequently, the Pt ALD growth rate reached a steady state linear growth regime for &amp;gt;50 ALD cycles. These measurements suggest that the Pt ALD first forms a number of nanoclusters that grow slowly during the first 38 ALD cycles. These islands then merge during the next 12 cycles and yield a steady state Pt ALD growth rate of ∼0.05 nm/cycle for &amp;gt;50 ALD cycles. The Pt ALD film at the onset of the steady state linear growth regime was approximately 2–3 nm in thickness. However, the SEM images of these Pt ALD films appeared corrugated and wormlike. These films also had a density that was only 50–70% of bulk Pt. Film densities that were consistent with bulk Pt were not observed until after &amp;gt;100 ALD cycles when the Pt ALD films appeared much smoother and were 4–5 nm in thickness. The Pt ALD nucleation rate could be enhanced somewhat using different O2 plasma parameters.
Effect of reactant and product melting on self-propagating reactions in multilayer foils (2002)

The evolution of self-propagating reactions along nanostructured multilayer foils is analyzed computationally. A simplified physical model is used that combines a two-dimensional diffusion equation for the atomic concentration with a quasi-one-dimensional form of the energy equation which accounts for the melting of the reactants and products. The model thus generalizes previous formulations which have ignored melting effects. The computations are used to predict the evolution of self-propagating fronts in Ni/Al foils, and analyze the dependence of these fronts on the foil parameters. In particular, the results indicate that melting substantially affects the properties of the unsteady reactions, and generally results in an appreciable reduction of the average front speed.
Day-ahead electricity market forecasting using kernels (2013)

Weather and life cycles, fuel markets, reliability rules, scheduled and random outages, renewables and demand response programs, all constitute pieces of the electricity market puzzle. In such a complex environment, forecasting electricity prices is a very challenging task; nonetheless, it is of paramount importance for market participants and system operators. Day-ahead price forecasting is performed in the present paper using a kernel-based method. This machine learning approach offers unique advantages over existing alternatives, especially in systematically exploiting the spatio-temporal nature of locational marginal prices (LMPs), while nonlinear cause-effect relationships can be captured by carefully selected similarities. Beyond conventional time-series data, non-vectorial attributes (e.g., hour of the day, day of the week, balancing authority) are transparently utilized. The novel approach is tested on real data from the Midwest ISO (MISO) day-ahead electricity market over the summer of 2012, during which MISO's load peak record was observed. The resultant day-ahead LMP forecasts outperform price repetition and ordinary linear regression, thus offering a promising inference tool for the electricity market.
Supplementary Data from L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma (2023)

Supplementary Data from L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma
Light-Emitting Transistor Based on Ultra-Thin Silicon (2007)

We confirmed enhanced electroluminescence by lateral carrier injections to quantum confined ultra-thin silicon. The optical intensity can be controlled by the back gate voltage, and the device operates as a light-emitting transistor.
Silkmoth chorion proteins. Their diversity, amino acid composition, and the NH-terminal sequence of one component (1978)

Silkmoth eggshell (chorion) proteins have been characterized by electrophoresis on sodium dodecyl sulfate and isoelectric focusing polyacrylamide gels; up to 33 and 41 components, respectively, were detected from a single chorion. Some of these components are polymorphic, being absent from chorions of certain animals. A system of nomenclature for all chorion proteins is presented, based on their separation on sodium dodecyl sulfate and isoelectric focusing gels. The chorion is enriched in glycine, alanine, cysteine, and tyrosine and poor in methionine and histidine. The proteins were fractionated into four partially overlapping groups; all four are enriched in the above amino acids, although significant differences exist. Further fractionation by isoelectric focusing of one of the above groups, s/s, yielded seven components, two of which are homogeneous both on sodium dodecyl sulfate and isoelectric focusing gels. The amino acid compositions, molecular weights, and solubility properties of the components share certain features which distinguish s/s as a group from the other three groups. The sequence of the first 67 NH2-terminal residues of a homogeneous protein purified from s/s has been determined. The protein contains a cysteine-rich tail (3 cysteines in the first 18 residues) followed by a 49-residue segment which contains only a single cysteine residue. This latter segment also contains two different tetrapeptide sequences which are each repeated, one twice and the other four times.
Toward the soil poultice and a new separations methodology: rebinding of macrocyclic metal complexes to molecularly imprinted polymers specifically templated via noncovalent interactions (2005)

The siderophore-based extraction of iron from the soil by bacteria is proposed as a model for a new separation methodology labeled the soil poultice, a molecular device that would selectively retrieve the complex of a targeted metal ion. In this first feasibility study we describe the synthesis and characterization of molecularly imprinted polymers based on noncovalent interactions, and their application in the specific recognition of macrocyclic metal complexes. The imprinting by salts of {N, N′, N′′, N′′′-tetra(2-cyanoethyl)cyclam}nickel(II) and {N, N′, N′′, N′′′-tetra(2-carbamoylethyl)cyclam}nickel(II) involves multiple hydrogen-bonding interactions when combined during copolymerization with the functional monomer acrylamide or with the crosslinking monomer N,N′-ethylenebisacrylamide. Good rebinding capacity for the imprinting metal complex was observed in both acetonitrile and water. Parallel experiments using the vinylsulfonate salt of either nickel(II) complex adds electrostatic interactions, and use of good coordinating groups as functional monomers (e.g. vinyl pyridines) adds a minor ligand component. Imprinted polymers using pairs of interactions (hydrogen bonding plus electrostatic attractions or hydrogen bonding plus minor ligand binding) exhibit greatly increased rebinding abilities, revealing a most promising synergism between pairs of supramolecular modes of attraction. Furthermore, imprinting the polymers with the β isomer of {N,N′,N′′,N′′′-tetra(2-carbamoylethyl)cyclam}nickel(II) perchlorate led to a marked preference for reuptake of the β isomer, exemplifying a substantial stereoselectivity. The reuptake of the β isomer was eight times that of the α isomer. The polymers are resistant to strong acids and oxidizing agents and show an increase in rebinding capacity during cycles of reuse. The affinities of the same ligands were determined for a number of metal ions, revealing high degrees of selectivity for Hg(II) and Cu(II). The imprinting procedure, combined with the accompanying selective chelation by macrocyclic ligands, supports the possibility of a new methodology for efficient extraction of metal ions under conditions not necessarily amenable to conventional techniques.
The protective effect of the NOD.Idd3 genetic interval is associated with enhanced regulatory T cell function and IL-10 production (B37) (2007)

Abstract The Idd3 genetic interval confers protection against multiple autoimmune diseases, including type 1 diabetes and experimental autoimmune encephalomyelitis (EAE). However, the cellular and molecular mechanisms by which the Idd3 locus mediates suppression of autoimmunity have not been analyzed. The favored candidate gene in this interval is Il2, which has been shown to be polymorphic between susceptible and resistant strains of mice. IL-2 regulates the growth/death of effector T cells as well as the generation/maintenance of regulatory T cells (Tregs). We have examined both Tregs and effector T cells in NOD and NOD.Idd3 congenic mice and find that NOD.Idd3 Tregs are more suppressive and NOD.Idd3 effector T cells produce more IL-10 when compared to NOD-derived T cells. Interestingly, we find that both these effects are driven by NOD.Idd3-derived antigen presenting cells, suggesting that the protective effect of Idd3 is due to alterations in the APC compartment and not T cells themselves.
CT Field of View Extension Using Combined Channels Extension and Deep Learning Methods (2019)

This paper proposes a method to extend the field of view of computed tomography images. In a first step, the field of view is increased by extrapolating linearly the outer channels in the sinogram space. The modified sinogram is then used to reconstruct extended field of view (EFoV) images containing artifacts due to the channels extension. In a second step, those artifacts are reduced by a deep learning network in image space. The proposed method has been evaluated on a collection of clinical scans. The resulting volumes have been checked for consistency and plausibility and compared to an existing state of the art EFoV method.
A scaled thermal-diffusivity-based frequency reference in 0.16&#x03BC;m CMOS (2011)

A 16MHz frequency reference that exploits the well-defined thermal diffusivity of IC-grade silicon is presented. The reference is realized in a 0.16μm baseline CMOS process. Occupying 0.5mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , its absolute inaccuracy after a room temperature trim is ±0.1% from -55°C to 125°C (24 samples). Its cycle-to-cycle jitter is less than 45ps (rms), and it dissipates 2.1mW from a 1.8V supply. Compared to a previous design in a 0.7μm CMOS process, this work achieves 10× higher frequency, 7× less jitter, 3.7× less power, and 12× less chip area, while maintaining the same accuracy. This demonstrates that thermal-diffusivity-based frequency references benefit strongly from technology scaling.
Novel Technologies for High Precision Characterization of Fibers (2015)

Optical fiber gain profiling, spectrogram modal analysis, and interferometric refractive index and residual stress measurement are reviewed. These novel characterization technologies are important for designing, assembling and optimizing fiber-based lasers and amplifiers.
Differences in the mirror reactionsH3(p,γ)4He andHe3(n,γ)4He from an isospin conserving nuclear force (1988)

The radiative capture reactions $^{3}(\mathit{p}$,\ensuremath{\gamma}${)}^{4}$He and $^{3}(\mathit{n}$,\ensuremath{\gamma}${)}^{4}$He are studied within the framework of a microscopic multichannel resonating group model. Employing a charge symmetric nuclear force we find different thresholds for the mirror channels due to the Coulomb force. These differences in term together with channel coupling effects lead to marked variations between observables of the two mirror reactions. We demonstrate that all types of experimental data can be reproduced by our calculation except for the controversial integrated (n,\ensuremath{\gamma}) cross section data.
Molecular Imaging to Predict Response to Targeted Therapies in Renal Cell Carcinoma (2017)

Molecular magnetic resonance imaging targeted to an endothelial integrin involved in neoangiogenesis was compared to DCE-US and immunochemistry to assess the early response of three different therapeutic agents in renal cell carcinoma. Human A498 renal cells carcinoma was subcutaneously inoculated into 24 nude mice. Mice received either phosphate-buffered saline solution, sunitinib, everolimus, or bevacizumab during 4 days. DCE-US and molecular MRI targeting <i>α</i>v<i>β</i>3 were performed at baseline and 4 days after treatment initiation. PI, AUC, relaxation rate variations Δ<i>R</i>2<sup>⁎</sup>, and percentage of vessels area quantified on CD31-stained microvessels were compared. Significant decreases were observed for PI and AUC parameters measured by DCE-US for bevacizumab group as early as 4 days, whereas molecular <i>α</i>v<i>β</i>3-targeted MRI was able to detect significant changes in both bevacizumab and everolimus groups. Percentage of CD31-stained microvessels was significantly correlated with DCE-US parameters, PI (<i>R</i> = 0.87, <i>p</i> = 0.0003) and AUC (<i>R</i> = 0.81, <i>p</i> = 0.0013). The percentage of vessel tissue area was significantly reduced (<i>p</i> < 0.01) in both sunitinib and bevacizumab groups. We report an early detection of neoangiogenesis modification after induction of targeted therapies, using DCE-US or <i>α</i>v<i>β</i>3-targeted MRI. We consider these outcomes should encourage clinical trial developments to further evaluate the potential of this molecular MRI technique.
The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data (2018)

Low back pain resulting from intervertebral disk degeneration is a cause of substantial disability and productivity loss. Over the past few years, growing evidence exists which suggests that low-grade bacterial infection, particularly infection with Cutibacterium acnes, may be associated with degenerative disk disease in the lumbar spine. Positive cultures are obtained in approximately 30% of intervertebral disk specimens removed at the time of surgery. In addition, one randomized trial has shown that antibiotic therapy for low back pain in patients with disk degeneration can slow the progression of degeneration and improve pain and disability levels. Although these results are encouraging, the link between infection and disk degeneration remains controversial. Investigators have attempted to address the limitations of clinical research by using translational methods and animal models. These methods have shown that seeding of the disk with bacteria can lead to increased local inflammation and an in vivo phenotype that is similar to human disk degeneration. This review seeks to provide an overview of the clinical, translational, and animal model data linking infection to disk degeneration. We review mechanisms for disk degeneration in the setting of infection and explore areas for future investigation.
<title>Preprocessing video images for neural learning of lipreading</title> (1994)

We present new procedures for preprocessing video images for automatic lipreading applications.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
ChemInform Abstract: 17O NMR Spectroscopic Data for Carbonyl Compounds. Part 1. Aldehydes and Ketones. Part 2. Carboxylic Acids and Derivatives (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Altered Gene Expression Profiles in the Brain, Kidney, and Lung of Deceased Neonatal Cloned Pigs (2010)

Limited studies have been published analyzing the gene expression patterns of cloned pigs. We compared the expression profiles of brain, kidney, and lung tissues, representing each of the three germ layers, of deceased neonatal cloned pigs with those of age-matched controls using a 13K oligonucleotide microarray. We found 42 (0.7% of total genes analyzed), 178 (2.9%), and 121 (1.9%) genes differentially expressed in the brain, kidney, and lung of clones, respectively, when compared with the corresponding organs from controls (fold change >1.5, p < 0.05, false discovery rate (FDR) = 0.05). These expression aberrations could potentially cause the following pathological anomalies in clones: diabetic nephropathy in the kidney and dysregulated surfactant homeostasis in the lung. Interestingly, upregulated expression of genes belonging to the MAPK pathway was observed in all three organs. To investigate whether the differences in levels of gene expression were caused by differential DNA methylation, the global DNA methylation level was measured by high-performance liquid chromatography. In controls, global concentration of methylated cytosine was 5.35%, whereas clones had significantly hypomethylated genomic DNA (4.57%). Bisulfite-pyrosequencing analyses of the promoter regions of differentially expressed candidate genes, c-MYC, Period 1 (PER1), Cathepsin L (CTSL), and Follistatin (FS), however, did not show any differences in the degree of DNA methylation between controls and clones. Our findings demonstrate that deceased neonatal cloned pigs have considerable gene expression abnormalities, which may have contributed to the death of the animals.
A Frequency-Domain Recursive Least-Squares Adaptive Filtering Algorithm Based On A Kronecker Product Decomposition (2023)

This paper proposes a frequency-domain recursive least-squares (RLS) adaptive filtering algorithm for identifying time-varying acoustic systems in noisy environments. The Kronecker product (KP) is employed to decompose the model filter of the acoustic channel impulse response into two sets of short sub-filters, based on which a generalized frequency-domain signal model and the associated cost function are established. A KP based RLS algorithm is subsequently deduced. In comparison with the conventional frequency-domain RLS adaptive filter, the presented algorithm is not only computationally more efficient, but also has a faster convergence rate for the identification of acoustic systems regardless of whether the excitation is a white sequence or a speech signal.
Placebos, Antacids and Cimetidine for Duodenal Ulcer (1978)

Cimetidine came on the scene just after the development of excellent endoscopic methods for visualizing duodenal ulcers. These better endoscopes, together with the need for intensive clinical studies before cimetidine could be released, have resulted in more reliable data on medical therapy of peptic ulcer than had been produced in the previous 100 years. However, the information has come so fast that it is hard to keep up with it, let alone understand what it all means. It is especially difficult to put cimetidine and older drugs in proper perspective. Since space is limited and data are more definitive, I . . .
Supplementary Movie 1 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression (2023)

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