gebhart/patrepeval huggingface dataset:
PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer’s Disease (2012)

We have demonstrated that the polyethylene glycol (PEG) corona of long-circulating polymeric nanoparticles (NPs) favors interaction with the amyloid-beta (Aβ(1-42)) peptide both in solution and in serum. The influence of PEGylation of poly(alkyl cyanoacrylate) and poly(lactic acid) NPs on the interaction with monomeric and soluble oligomeric forms of Aβ(1-42) peptide was demonstrated by capillary electrophoresis, surface plasmon resonance, thioflavin T assay, and confocal microscopy, where the binding affected peptide aggregation kinetics. The capture of peptide by NPs in serum was also evidenced by fluorescence spectroscopy and ELISA. Moreover, in silico and modeling experiments highlighted the mode of PEG interaction with the Aβ(1-42) peptide and its conformational changes at the nanoparticle surface. Finally, Aβ(1-42) peptide binding to NPs affected neither complement activation in serum nor apolipoprotein-E (Apo-E) adsorption from the serum. These observations have crucial implications in NP safety and clearance kinetics from the blood. Apo-E deposition is of prime importance since it can also interact with the Aβ(1-42) peptide and increase the affinity of NPs for the peptide in the blood. Collectively, our results suggest that these engineered long-circulating NPs may have the ability to capture the toxic forms of the Aβ(1-42) peptide from the systemic circulation and potentially improve Alzheimer's disease condition through the proposed "sink effect".
Unconnected junction contrast in ion beam induced charge microscopy (1996)

A new contrast mechanism in ion beam induced charge imaging in semiconductors is reported. Junctions not directly connected to the charge collection preamplifier were found to give rise to significant charge collection signals. Imaging with these signals is carried out, thus enabling the mapping of junctions not directly connected to the charge collection amplifier.
100 Gbps coherent digital CFP interface for short reach, regional, and ultra long-haul optical communications (2015)

For the first time, we show that 100G coherent digital CFP is efficient to address short-reach (<;150 km), regional (<;1000 km), and ultra long-haul (~2000 km) transmission applications with half the cost, one third the power consumption and one quarter the size of common 100G WDM interfaces.
Neuropeptide Y Infusion Decreases Plasma Renin Activity in Postmyocardial Infarction Rats (1994)

We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF). CHF was produced by prior (6-8 weeks) ligation of the left coronary artery; control rats were sham-operated. Carotid arterial blood was drawn for PRA and NE in conscious unrestrained rats that had been instrumented 24 h earlier. MI rats had increased PRA as compared with sham-operated rats [8.73 +/- 1.27 vs. 5.10 +/- 0.91 ng angiotensin (AI) I/ml.h, mean +/- SE]. During chronic NPY infusion, PRA was reduced to normal in the MI group (4.78 +/- 0.91) but was not affected in the sham group (5.65 +/- 0.51). Plasma NE was altered similarly, but the changes did not reach statistical significance. These data suggest that NPY has the capacity to restrain renin release in moderate compensated CHF.
In Vivo Three-Dimensional Determination of Kinematics for Subjects with a Normal Knee or a Unicompartmental or Total Knee Replacement (2001)

Dennis, Douglas MD; Komistek, Richard PhD; Scuderi, Giles MD; Argenson, Jean-Noel MD; Insall, John MD; Mahfouz, Mohamed MS; Aubaniac, Jean-Manuel MD; Haas, Brian MD Author Information
A fully decoupled LC tank VCO based 16 to 19 GHz PLL in 130nm SiGe BiCMOS achieving −131dBc/Hz phase noise at 10MHz offset (2017)

This paper describes a technique for reducing oscillator phase noise through a circuit topology that decouples the LC tank from the active devices, achieving a higher amplitude of oscillation not limited by the active device breakdown voltage. This fully decoupled LC tank topology also reduces noise injection into the tank, which, coupled with the higher tank swing, results in low phase noise operation. As proof of concept, a VCO operating at 16 to 19 GHz is implemented in the IBM 130nm SiGe BiCMOS technology f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> /f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> of 200/280 GHz). The VCO achieves a phase noise of -131dBc/Hz at a 10MHz offset from the carrier.
Light-Controlled Selective Metal Deposition on a Photochromic Diarylethene Film—Toward New Applications in Electronics and Photonics— (2010)

Abstract Selective metal deposition controlled by light irradiation was achieved for Zn, Mg, and Mn on a photochromic diarylethene (DAE) film; metal vapor atoms were deposited only on the colored film but not on the uncolored film. The deposition properties of the metals were strongly dependent on the deposition rates. Fine metal patterns were produced by laser scanning and a conventional vacuum-evaporation method without a shadow mask. Multiple-metal pattern preparation of Zn, Mg, and Mn via a maskless evaporation in a single vacuum process was also demonstrated.
Rigid and non-rigid motion compensation in weight-bearing cone-beam CT\n of the knee using (noisy) inertial measurements (2021)

Involuntary subject motion is the main source of artifacts in weight-bearing\ncone-beam CT of the knee. To achieve image quality for clinical diagnosis, the\nmotion needs to be compensated. We propose to use inertial measurement units\n(IMUs) attached to the leg for motion estimation. We perform a simulation study\nusing real motion recorded with an optical tracking system. Three IMU-based\ncorrection approaches are evaluated, namely rigid motion correction, non-rigid\n2D projection deformation and non-rigid 3D dynamic reconstruction. We present\nan initialization process based on the system geometry. With an IMU noise\nsimulation, we investigate the applicability of the proposed methods in real\napplications. All proposed IMU-based approaches correct motion at least as good\nas a state-of-the-art marker-based approach. The structural similarity index\nand the root mean squared error between motion-free and motion corrected\nvolumes are improved by 24-35% and 78-85%, respectively, compared with the\nuncorrected case. The noise analysis shows that the noise levels of\ncommercially available IMUs need to be improved by a factor of $10^5$ which is\ncurrently only achieved by specialized hardware not robust enough for the\napplication. The presented study confirms the feasibility of this novel\napproach and defines improvements necessary for a real application.\n
Zero Additional Process, Local Charge Trap, Embedded Flash Memory with Drain-Side Assisted Erase Scheme Using Minimum Channel Length/Width Standard Complemental Metal–Oxide–Semiconductor Single Transistor Cell (2012)

This paper proposes for the first time the completely complemental metal–oxide–semiconductor (CMOS) compatible embedded flash memory with the small cell size as well as the lowest process cost. The single transistor cell with the minimum channel length and width realizes the ideal smallest cell. The non-volatile memory operation is realized with locally injected electrons at the drain-edge by the hot electron injection. This paper also proposes the novel forward-bias assisted erase. The proposed memory is experimentally demonstrated with the 65 nm standard CMOS process without additional process or mask. The cell size is 10F2 with the 65 nm CMOS logic design rule. The excellent reliability such as 100-times program/erase endurance, 10-year data retention and high immunity to the read/program/erase disturb is also experimentally demonstrated. The proposed cell is the ideal candidate for the code-storage embedded non-volatile memories in system-on-chip and microcontroller unit.
Supplementary Figure 1 from Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 1: Validation of RWV-366T - PDF file 5154K, Verification of renal origins and confirmation of patient tissue match for RWV-366T ccRCC cell line&lt;/p&gt;
Influence of Temperature and Growth Phase on Expression of a 104-Kilodalton Listeria Adhesion Protein in Listeria monocytogenes (1999)

Interaction of Listeria monocytogenes with mammalian intestinal cells is believed to be an important first step in Listeria pathogenesis. Transposon (Tn916) mutagenesis provided strong evidence that a 104-kDa surface protein, designated the Listeria adhesion protein (LAP), was involved in adherence of L. monocytogenes to a human enterocyte-like Caco-2 cell line (V. Pandiripally, D. Westbrook, G. Sunki, and A. Bhunia, J. Med. Microbiol. 48:117-124, 1999). In this study, expression of LAP in L. monocytogenes at various growth temperatures (25, 37, and 42 degrees C) and in various growth phases was determined by performing an enzyme-linked immunoassay (ELISA) and Western blotting with a specific monoclonal antibody (monoclonal antibody H7). The ELISA and Western blot results indicated that there was a significant increase in LAP expression over time only at 37 and 42 degrees C and that the level of LAP expression was low during the exponential phase and high during the stationary phase. In contrast, there were not significant differences in LAP expression between the exponential and stationary phases at 25 degrees C. Examination of the adhesion of L. monocytogenes cells from exponential-phase (12-h) or stationary-phase (24-h) cultures grown at 37 degrees C to Caco-2 cells revealed that there were not significant differences in adhesion. Although expression of L. monocytogenes LAP was different at different growth temperatures and in different growth phases, enhanced expression did not result in increased adhesion, possibly because only a few LAP molecules were sufficient to initiate binding to Caco-2 cells.
Proline addition increases the efficiency of l‐lysine production by Corynebacterium glutamicum (2013)

The wild type of Corynebacterium glutamicum does not excrete l ‐lysine, but mutants are developed to use C. glutamicum for the large‐scale production of this amino acid. l ‐lysine is derived from oxaloacetate and pyruvate. A reduced entry of these precursors into the citric acid cycle triggers l ‐lysine synthesis, but there is simultaneously an unfavorable reduction in growth rate. Here, we further investigated strains with reduced citrate synthase activity and observed that proline supplementation partly reversed the growth rate reduction, and simultaneously increased l ‐lysine accumulation by 10%. The combined effect of faster growth and higher l ‐lysine formation lead to an increase in l ‐lysine productivity of about 14%. Small scale bioreactor cultivations showed an increase of the glucose uptake rate from 3.96 to 5.12 mmol g CDW −1 h −1 as the effect of proline addition. Deletion of the proline‐utilization gene put A demonstrated that proline did not serve to refill the citric acid cycle. The combined data show that proline addition has a favorable effect on l ‐lysine formation and sugar uptake, which indicates that engineering sugar uptake is a future option for increased product formation.
Hysteresis-free polymer-stabilized blue phase liquid crystals using thermal recycles (2012)

We demonstrate a hysteresis-free polymer-stabilized blue phase liquid crystals (PSBP-LCs) using thermal recycles by means of enlarging the domain size of PSBP-LC and improving the uniformity of the crystal orientations of PSBP-LC. The crystal growth of PSBP-LCs bases on a competition between the heterogeneous nucleation and the homogeneous nucleation is also demonstrated and discussed. This study opens a new window for understanding the hysteresis of the PSBP-LC and assisting in designing many PSBP-LC-based photonic devices, such as displays, electro-optical switches, and electrically tunable focusing LC lenses.
Macrophage cell adhesion and inflammation cytokines on magnetostrictive nanowires (2007)

A common problem with medical implants is the biofouling response which can detrimentally damage implants or prevent the implant from function properly. This response is characterized by a thick, frequently avascular, layer of proteins and cells over the implant. To study this problem, we have examined here the adhesion of macrophages and the subsequent expression of inflammatory cytokines on nanowire arrays. We found that the cells on the nanowires typically occupied less area and were more circular than on a flat surface of the same material as the nanowires or tissue culture polystyrene (TCPS) in both the presence and absence of fetal bovine serum. Furthermore, this difference was amplified by pre-coating the surfaces with collagen. The smaller area and circular shape indicated that the cells were not thriving on the surface. Since there was potentially a high amount of cell death on the material, and biofouling is frequently characterized as a chronic inflammation, an eighteen cytokine Luminex® panel was performed on the supernatant from macrophages on nanowires, control wafers, and TCPS. As a positive control for inflammation, lipopolysaccharide (LPS) was added to macrophages on TCPS to estimate the maximum inflammation response of the macrophages. Our results indicated that the nanowire structure results in the up-regulation of production in macrophages of inflammatory cytokines such as IL-1α, and IFN-γ and the down-regulation of IL-6, compared to control wafers. In addition, the nanostructure also increased the production of IL-10 which is known as an inhibitor of inflammation. Our results showed that the nanoarchitecture can disrupt cell adhesion and may lead to an inflammatory response.
Expression of CD3-associated antigen-binding receptors on suppressor T cells. (1988)

Three suppressor T (Ts)-cell hybridomas specific for 4-hydroxy-3-nitrophenyl acetyl (NP) hapten were selected for surface expression of cluster determinant 3 (CD3) by using antibody (anti-CD3) or antigen (NP-bovine serum albumin) panning procedures followed by cloning at limiting dilution. The CD3-selected Ts hybridomas showed a 1-2 logarithmic enrichment in suppressor activity when compared to the parent lines; they also specifically bound NP-coupled sheep red blood cells in rosette assays. This antigen-binding ability could be down-modulated by anti-CD3 antibody. Similarly, surface expression of CD3 was specifically down-modulated by preincubation of these hybridomas with antigen. Anti-CD3 monoclonal antibody under reducing conditions coprecipitated a broad band of 38-50 kDa associated with two CD3 (25 and 16 kDa) bands. T-cell receptor, anti-alpha-specific monoclonal antibody also immunoprecipitated a broad band in the 41 to 49-kDa region. The combined results suggest that, like helper and cytotoxic T lymphocytes, Ts cells also bear antigen-specific receptors associated with CD3 molecules.
G050023 Effects of the degree of overbite on the intraoral fluid dynamics upon the production of sibilant /s/ (2011)

A large eddy simulation was implemented to investigate the effect of the degree of overbite, which refers to the extent of vertical overlap of the maxillary central incisors over the mandibular central incisors, on the flow in the simplifiedoral cavity model that morphologically simplifies the oral cavity when sibilant was produced. The result illustrated thathigh Powell's sound sources were generated along the upstream surface of the upper obstacle to which a flow separatedfrom the lower obstacle impinged and in the separated flow from the edge of the upper obstacle. Extension of theoverbite resulted in enlargement of the regions of large Powell's sound sources in those regions.
Weighted proportional loss rate differentiation of TCP traffic (2004)

Abstract Relative service differentiation refers to service models that provide assurances for the relative quality ordering between classes, rather than for the absolute service level in each class. An example is the proportional differentiation model which provides a way to control the quality spacing between classes locally at each hop. In this model, certain forwarding metrics are ratioed proportional to the class differentiation parameters that the network operator chooses. In this paper, we propose a new proportional loss rate differentiation mechanism that integrates relative loss rate differentiation directly into active queue management using random early detection. Copyright © 2004 John Wiley &amp;Sons, Ltd.
Ethanol-Induced Leukocyte Adherence and Albumin Leakage in Rat Mesenteric Venules: Role of CD18/Intercellular Adhesion Molecule-1 (1996)

The adherence and emigration of leukocytes have been implicated as a rate-limiting step in the microvascular disturbance in a variety of pathogenic events. The objective of the present study was to investigate leukocyte-endothelial cell adhesion and endothelial barrier function in rat mesenteric microvessels exposed to ethanol, which is known to cause inflammation and injury in various organs. Mesentery of male Wistar rats was used for intravital microscopic observations. Leukocyte adherence and albumin leakage were monitored in single postcapillary venules using the intravital fluorescence microscope. Supervision of 50 mM ethanol elicited the leukocyte adherence and albumin leakage within 60 min. Pretreatment with a monoclonal antibody directed against either CD18 or intercellular adhesion molecule-1 (ICAM-1) significantly prevented the ethanol-induced increase in leukocyte adherence and decrease in barrier function of endothelium. These results suggest that ethanol-induced leukocyte adherence is mediated by CD18 on leukocytes and ICAM-1 on endothelial cells. The present study further supports that CD18/ ICAM-1-dependent leukocyte-endothelial adhesive interactions lead to macromolecular leakage in the postcapillary venules exposed to ethanol.
A strategy for a general search for new phenomena using data-derived signal regions and its application within the ATLAS experiment (2019)

This paper describes a strategy for a general search used by the ATLAS Collaboration to find potential indications of new physics. Events are classified according to their final state into many event classes. For each event class an automated search algorithm tests whether the data are compatible with the Monte Carlo simulated expectation in several distributions sensitive to the effects of new physics. The significance of a deviation is quantified using pseudoexperiments. A data selection with a significant deviation defines a signal region for a dedicated follow-up analysis with an improved background expectation. The analysis of the data-derived signal regions on a new dataset allows a statistical interpretation without the large look-elsewhere effect. The sensitivity of the approach is discussed using Standard Model processes and benchmark signals of new physics. As an example, results are shown for 3.2 fb -1 of protonproton collision data at a centre-of-mass energy of 13 TeV collected with the ATLAS detector at the LHC in 2015, in which more than 700 event classes and more than 10 5 regions have been analysed. No significant deviations are found and consequently no data-derived signal regions for a follow-up analysis have been defined.
Correction to Toward the Synthesis of Wafer-Scale Single-Crystal Graphene on Copper Foils (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Toward the Synthesis of Wafer-Scale Single-Crystal Graphene on Copper FoilsZheng Yan, Jian Lin, Zhiwei Peng, Zhengzong Sun, Yu Zhu, Lei Li, Changsheng Xiang, E. Loïc Samuel, Carter Kittrell, and James M. Tour*Cite this: ACS Nano 2013, 7, 3, 2872Publication Date (Web):March 5, 2013Publication History Published online5 March 2013Published inissue 26 March 2013https://pubs.acs.org/doi/10.1021/nn400234bhttps://doi.org/10.1021/nn400234bcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1262Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (44 KB) Get e-AlertscloseSUBJECTS:Copper,Transmission electron microscopy,Two dimensional materials Get e-Alerts
Synthesis of 2-Substituted Benzothiazoles from 2-Fluorophenylisothiocyanate (1991)

Abstract Treatment of 2-fluorophenylisothiocyanate with a Grignard reagent, followed by base-induced cyclization of the resulting thioamide, provides a convenient method of synthesizing 2-substituted benzothiazoles. Best results are obtained upon isolation and purification of the intermediate thioamide, but a direct one-pot isothiocyanate-to-benzothiazole transformation has also been achieved.
ChemInform Abstract: Enantioselective Synthesis of Naturally Occurring trans‐4‐Hydroxy‐S‐ pipecolic Acid‐4‐sulfate, a New Potent and Selective NMDA Receptor Agonist. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Group-based Cryptography in the Quantum Era (2022)

In this expository article we present an overview of the current state-of-the-art in post-quantum group-based cryptography. We describe several families of groups that have been proposed as platforms, with special emphasis in polycyclic groups and graph groups, dealing in particular with their algorithmic properties and cryptographic applications. We then, describe some applications of combinatorial algebra in fully homomorphic encryption. In the end we discussing several open problems in this direction.