gebhart/patrepeval huggingface dataset:
Inkjet-Printed Polyelectrolyte Seed Layer-Based, Customizable, Transparent, Ultrathin Gold Electrodes and Facile Implementation of Photothermal Effect (2023)

Recently, interest in transparent electrodes has been increasing in biomedical engineering applications for such as electro-optical hybrid neuro-technologies. However, conventional photolithography-based electrode fabrication methods have limited design customization and large-area applicability. For biomedical engineering applications, it is crucial that we can easily customize the electrode design for different patients over a large body area. In this paper, we propose a novel method to fabricate customization-friendly, transparent, ultrathin, gold microelectrodes using inkjet printing technology. Unlike with typical direct printing of conductive inks, we inkjet-printed a polymer nucleation-inducing seed layer, followed by mask-less vacuum deposition of ultrathin gold (<6 nm) to produce selectively, high-transparency electrodes in the predefined shapes of the inkjet-printed polymer. Owing to the design flexibility of inkjet printing, the transparent ultrathin gold electrodes can be highly efficient in design customization over a large area. Simultaneously, a layer of nonconductive gold islands is formed in the nonprinted region, and this nanostructured layer can implement a photothermal effect that offers versatility for novel biomedical applications. As a demonstration of the effectiveness of these transparent electrodes, and the facile implementation of the photothermal effect for biomedical applications, we successfully fabricated transparent resistive temperature detectors. We used these to directly sense the photothermal effect and to demonstrate their bioimaging capabilities.
Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma (2021)

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are current standard of care for patients with EGFR mutation and metastatic non-small-cell lung carcinoma (NSCLC), but most patients using EGFR TKIs acquire resistance later. So, overcoming resistance of EGFR TKIs has become an important issue in the treatment of NSCLC. Previously, therapeutics targeting Bruton's tyrosine kinase (BTK) have been successful in treating several hematologic malignancies. However, the role of BTK in NSCLC is still unknown. In this study, by examining surgical specimens from 80 NSCLC patients and their clinicopathologic parameters, we found significant correlation between high BTK expression and tumor differentiation, p-stage, lymph node metastatic status, maximum tumor size, and poor prognosis of patients. Using two NSCLC cell lines A540 and PC9, we demonstrated that BTK<sup>pos</sup> cells exhibited more stemness (OCT4, SOX2) and EMT (E-Cadherin, Slug) markers than BTK<sup>neg</sup> cells. Knockdown of BTK sensitized the NSCLC cells to Gefitinib. Meanwhile, the second-generation BTK inhibitor Acalabrutinib effectively suppressed SOX2, STAT3/JAK2/Akt axis and potentiated the anti-proliferative effect of Gefitinib and Osimertinib in NSCLC cells, including the T790M H1975 cells. Furthermore, Acalabrutinib and Osimertinib combination exhibited significant tumor growth inhibition of H1975-derived tumors in vivo. Our findings suggested that BTK mediates stemness and EMT properties, and inhibition of BTK potentiates the effect of Gefitinib and Osimertinib in NSCLC cells resistant to TKI. This implies a new approach to treat the NSCLC patients with resistance to previous TKI treatment.
Search for dark matter, extra dimensions, and unparticles in monojet events in proton-proton collisions at s = 8 TeV (2015)

Results are presented from a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum. The data were collected by the CMS detector in proton-proton collisions at the LHC and correspond to an integrated luminosity of 19.7 fb-1 at a centre-of-mass energy of 8TeV. The number of observed events is found to be consistent with the standard model prediction. Limits are placed on the DM-nucleon scattering cross section as a function of the DM particle mass for spin-dependent and spin-independent interactions. Limits are also placed on the scale parameter MD in the Arkani-Hamed, Dimopoulos, and Dvali (ADD) model of large extra dimensions, and on the unparticle model parameter ΛU. The constraints on ADD models and unparticles are the most stringent limits in this channel and those on the DM-nucleon scattering cross section are an improvement over previous collider results. © 2015, CERN for the benefit of the CMS collaboration.
Combination of anti‐CD4 antibody treatment and donor lymphocyte infusion ameliorates graft‐versus‐host disease while preserving graft‐versus‐tumor effects in murine allogeneic hematopoietic stem cell transplantation (2017)

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not only a well-established immunotherapy for hematologic malignancies, but is potentially useful for treating solid tumors refractory to available therapies. However, application of allo-HSCT to solid tumors is limited, despite the beneficial antitumor effects, by the risk of graft-versus-host disease (GVHD). CD4<sup>+</sup> T cells have been implicated in several aspects of GVHD, and suppress antitumor CD8<sup>+</sup> T-cell responses. In the present study, we investigated clinically applicable allo-HSCT protocols designed to maximize antitumor effects while reducing the risk of GVHD. We used a mouse model of allo-HSCT with s.c. tumors. We found that myeloablative conditioning was associated with better inhibition of tumor growth but with severe acute GVHD. Early treatment with anti-CD4 mAb substantially ameliorated GVHD while preserving antitumor effects, leading to improved survival in myeloablative allo-HSCT. Late treatment with anti-CD4 mAb also ameliorated GVHD to some extent. Donor lymphocyte infusion in GVHD mice treated with anti-CD4 mAb further suppressed tumor growth without exacerbating GVHD. Collectively, our results suggest that myeloablative allo-HSCT followed by anti-CD4 mAb treatment and donor lymphocyte infusion could be a potent and safe immunotherapy for patients with cancers refractory to available therapies.
Supplementary Data from Hepatitis C Virus Proteins Modulate MicroRNA Expression and Chemosensitivity in Malignant Hepatocytes (2023)

Supplementary Data from Hepatitis C Virus Proteins Modulate MicroRNA Expression and Chemosensitivity in Malignant Hepatocytes
Optical properties of tumor tissues grown on the chorioallantoic membrane of chicken eggs measured with a double integrating sphere and inverse Monte Carlo method (2013)

Photodynamic therapy (PDT) is a minimally invasive therapeutic procedure that can selectively destroy the tumor tissue with singlet oxygen. At present, we have investigated low-cost light source, light emitting diode (LED) for PDT as a light source. An LED array produces a spectral emission with a narrow bandwidth in the region of 5-20 nm. Considering the LED characteristic, it’s needed to analyze theoretically optimum PDT therapeutic dose with LED based on tissue optics. Fluence distribution is so important to evaluate PDT effective, and the fluence distribution depends on the tissue optical properties, i.e. absorption coefficient μa, scattering coefficient μs, anisotropy factor g, and refractive index. We study evaluation of PDT effective with tumor model prepared with tumor cells grown on the chorioallantoic membrane of chicken egg (CAM tumor model) which is a three dimensional tumor model. To estimate theoretically PDT effective, it is necessary to measure optical properties of CAM tumor tissues. Optical properties of mouse tumor tissues, which used in PDT preclinical test as a tumor model usually, are also needed to measure for the comparison with the CAM tumor. The purpose of this study is to determine optical properties of CAM and mouse tumor tissues, and compare them.
On-Line Seam Detection in Rolling Processes Using Snake Projection and Discrete Wavelet Transform (2007)

This paper describes the development of an on-line quality inspection algorithm for detecting the surface defect “seam” generated in rolling processes. A feature-preserving “snake-projection” method is proposed for dimension reduction by converting the suspicious seam-containing images to one-dimensional sequences. Discrete wavelet transform is then performed on the sequences for feature extraction. Finally, a T2 control chart is established based on the extracted features to distinguish real seams from false positives. The snake-projection method has two parameters that impact the effectiveness of the algorithm. Thus, selection of the parameters is discussed. Implementation of the proposed algorithm shows that it satisfies the speed and accuracy requirements for on-line seam detection.
Stability of (chloromethyl)platinum(II) complexes (1991)

The stabilities of [Pt(CH2Cl)2(cod)], [Pt(CH2Cl)Cl(cod)](cod = cycloocta-1,5-diene) and a range of phosphine-containing mono- and cis-bis-(chloromethyl)platinum(II) complexes have been investigated in deuteriochloroform at room temperature. Some of the bis(chloromethyl) derivatives appear to be indefinitely stable (cod and chelating arylphosphines), others suffer very slow decomposition to the dichlorides (non-chelating arylphosphines), and the remainder decompose relatively rapidly, and cleanly, to the dichlorides plus ethylene (alkylphosphines, non-chelating faster than chelating). Rapid decomposition of the arylphosphine complexes can be induced by adding hexafluoroisopropyl alcohol to the deuteriochloroform solutions. Attempts to generate [Pt(CH2Cl)2{P(C6H11)3}2] by addition of P(C6H11)3 to [Pt(CH2Cl)2(cod)] resulted in the formation of cis-[Pt–{CH2CH2P+(C6H11)3}Cl2{P(C6H11)3}]; a mechanism is proposed. All cis-mono(chloromethyl) derivatives studied appear to be indefinitely stable. In contrast, the trans-mono(chloromethyl) complexes, although stable in very dry solvent, undergo decomposition in the presence of moisture to the corresponding hydrides plus formaldehyde; a mechanism is proposed. The hydrides undergo subsequent conversion into a mixture of cis and trans dichlorides.
Attrition reactor system (2023)

A reactor vessel for reacting a solid particulate with a liquid reactant has a centrifugal pump in circulatory flow communication with the reactor vessel for providing particulate attrition, resulting in additional fresh surface where the reaction can occur.
Impaired left-ventricular cardiac function in male GPR30-deficient mice (2010)

G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the valves or outflow tract of the heart. Both the contractility and relaxation capacity of the left ventricle were reduced, leading to increased left‑ventricular end-diastolic pressure in GPR30-deficient mice. In conclusion, our data support a role for GPR30 in the gender-specific aspects of heart failure.
The Use of Vertical Interference Testing to Improve Reservoir Characterization (2000)

Abstract Stratified or layered carbonate reservoirs are common in the UAE and throughout the Middle East. For field development and reservoir management it is important to describe the layering in terms of the vertical and horizontal layer permeabilities and the vertical communication between layers. Vertical communication between layers affects the overall development plan, the economics and management of enhanced recovery projects. The number and placement of both injector and producer wells will require an accurate description of the layering. In this paper, we discuss the use Interval Pressure Transient Testing (IPTT), which is also commonly called Vertical Interference Testing, and Vertical Pressure Profiling in a major oil field in UAE. The objective was to characterize the vertical and horizontal layer permeabilities and vertical communication through the main producing reservoir section. In a newly drilled and uncompleted well, eight IPTT tests were conducted with a Formation Tester Dual Straddle Packer and two Probe Modules. The vertical pressure profile along the wellbore was also obtained for information about the geology and flow units as well as depletion. The interval pressure test at each location was interpreted using an appropriate geological model with the packer and probe pressure and flow rate measurements. The interpretation procedure consisted of identification of the different flow regimes followed by history (type curve) matching for the estimation of vertical and horizontal permeabilities for each layer. The interpretation of two of the interval pressure transient tests is presented.
A novel approach to timberwood fragrances (2012)

Timberone (1-(2,2,6-trimethylcyclohexyl)hexan-3-one), a compound interesting the fragrance industry, was synthesized in three steps, starting from readily available citral. All reaction steps could be catalyzed by heterogeneous catalysts in good selectivity.
Chaire d’innovation technologique - Liliane Bettencourt (2010)

Ondes et images Au cours de cette année scolaire, mon enseignement a été effectué sous différentes formes : une leçon inaugurale qui s’intitulait « Renversement du temps, ondes et innovation », une série de 8 cours (8 h) sur le thème « Ondes et Images », une série de 8 séminaires invités couplés à ces cours et enfin, à l’occasion du dernier cours, une après-midi consacrée aux nouvelles méthodes d’imagerie (3 h) dans le domaine du radar, de l’imagerie de la terre et sur le futur de l’imagerie ...
Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates (2013)

Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO[subscript 2]) in organic solvents. Palladium porphyrins are sensitive in the 0–160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. Appreciable overlap between QD emission and porphyrin absorption features results in efficient Forster resonance energy transfer (FRET) for signal transduction in these sensors. The QD serves as a photon antenna, enhancing porphyrin emission under both one- and two-photon excitation, demonstrating that QD-palladium porphyrin conjugates may be used for oxygen sensing over physiological oxygen ranges.
Lexical and syntactic priming and their impact in deployed spoken dialog systems (2009)

In this paper, we examine user adaptation to the system's lexical and syntactic choices in the context of the deployed Let's Go! dialog system. We show that in deployed dialog systems with real users, as in laboratory experiments, users adapt to the system's lexical and syntactic choices. We also show that the system's lexical and syntactic choices, and consequent user adaptation, can have an impact on recognition of task-related concepts. This means that system prompt formulation, even in flexible input dialog systems, can be used to guide users into producing utterances conducive to task success.
Double Yielding in a Styrene/Butadiene Star Block Copolymer (2004)

Abstract Summary: The morphology and tensile deformation behaviour of a highly asymmetric styrene/butadiene star block copolymer (polystyrene (PS) content = 74%) containing random PS‐ co ‐PB (polybutadiene) copolymer as a rubbery phase were investigated. The existence of double yielding, similar to that observed in some semicrystalline polymers, was detected in this nanostructured amorphous polymer. The observed phenomenon may be correlated with two different micromechanical processes taking place at the initial stage of deformation. The stress‐strain curve of the star block copolymer prepared here (each curve represents a different method). The two yield points are clearly visible (labelled I and II). image The stress‐strain curve of the star block copolymer prepared here (each curve represents a different method). The two yield points are clearly visible (labelled I and II).
Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain (2014)

Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation, and release of cyclic guanosine-3',5'-monophosphate (cGMP). Evidence that the visceral analgesic effects of linaclotide are mediated by a novel, GC-C-dependent peripheral sensory mechanism was first demonstrated in animal models of visceral pain. Subsequent studies with uroguanylin or linaclotide have confirmed the activation of a GC-C/cGMP pathway leading to increased submucosal cGMP mediated by cGMP efflux pumps, which modulates intestinal nociceptor function resulting in peripheral analgesia. These effects can be reproduced by the addition of exogenous cGMP and support a role for GC-C/cGMP signaling in the regulation of visceral sensation, a physiological function that has not previously been linked to the GC-C/cGMP pathway. Notably, targeting the GC-C/cGMP pathway for treatment of gastrointestinal pain and abdominal sensory symptoms has now been validated in the clinic. In 2012, linaclotide was approved in the United States and European Union for the treatment of adult patients with irritable bowel syndrome with constipation.
Enhancer Role of STAT5 in CD2 Activation of IFN-γ Gene Expression (2004)

IFN-gamma is an important immunoregulatory protein with tightly controlled expression in activated T and NK cells. Three potential STAT binding regions have been recognized within the IFN-gamma promoter: 1) an IL-12-mediated STAT4 binding site at -236 bp; 2) a newly identified IL-2-induced STAT5 binding element at -3.6 kb; and 3) CD2-mediated STAT1 and STAT4 binding to an intronic element in mucosal T cells. However, functional activation of these sites remains unclear. In this study we demonstrate CD2-mediated activation of the newly characterized -3.6-kb IFN-gamma STAT5 binding region. CD2 signaling of human PBMC results in activation of the -3.6-kb IFN-gamma promoter, whereas mutation of the -3.6-kb STAT5 site attenuates promoter activity. Functional activation is accompanied by STAT5A but little STAT5B nucleoprotein binding to the IFN-gamma STAT5 site, as determined by competition and supershift assays. STAT5 activation via CD2 occurs independent of IL-2. Western and FACS analysis shows increased phospho-STAT5 following CD2 signaling. AG490, a tyrosine kinase inhibitor affecting Jak proteins, inhibits CD2-mediated IFN-gamma mRNA expression, secretion, and nucleoprotein binding to the IFN-gamma STAT5 site in a dose-dependent fashion. This report is the first to describe CD2-mediated activation of STAT5 and supports STAT5 involvement in regulation of IFN-gamma expression.
<title>Use of light scatter signals to identify particle material</title> (2001)

Defect detection and counting have been used to qualify silicon wafers for use in device production for several years. Defect sizing is attempted by comparing scatter signals, used for detection, to signals produced from spherical polystyrene latex spheres of known diameter. Real particles are neither spherical nor made of plastic, and scatter differently. This paper addresses the issue of spherical particle material identification through the measurement of scatter signals into several directions. The basic idea is that the average diameter and material constants comprising the complex index amount to three unknowns. The question is whether they can be estimated from three independent measurements. The results presented here are quite positive. The issue of particle shape is left for another paper.
A CCD-based Detector for SPECT (2005)

We are investigating the use of a CCD for high-resolution radionuclide imaging. The use of a CCD has the potential to provide very high spatial resolution on the order of 200 to 400 /spl mu/m, while significantly simplifying the readout electronics. The detector is based on a special CCD with on-chip multiplication gain that allows high-speed operation while maintaining the read noise at a very low level of <1 electron. To achieve high detection efficiency and excellent spatial resolution for incident gamma flux, a specially fabricated thick microcolumnar CsI(Tl) scintillator was optically coupled to the CCD. A prototype SPECT imaging system was assembled by incorporating pinhole/parallel hole collimators in the design. The use of this system for radionuclide imaging has been demonstrated through tomographic imaging of a test phantom filled with /sup 99m/Tc.
ChemInform Abstract: SOLUBILIZING, ACID‐LABILE PEPTIDE PROTECTIVE GROUPS (1979)

Abstract Durch Addition von Triethylenglykolrnonomethylether (I) an das Keton (II) und anschließende Grignard‐Reaktion mit MgMeI erhält man den tertiären Alkohol (III), der mit Z‐Gly (IV) zu dem Säurelabilen Tpt‐Ester (V) umgesetzt wird, wobei die Veresterung unter erheblicher Raoemisierung verläuft.
NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation (2022)

We conclude that an important function of NK cells is to drive proper APC maturation <i>via</i> CD40L during responses to early-stage tumors, reducing development of anergic T cells. The reduced development of anergic T cells resulting in improved tumor control and T cell responses when NK cells were present.
Integrins stimulate phosphorylation of neurofilament NF‐M subunit KSP repeats through activation of extracellular regulated‐kinases (Erk1/Erk2) in cultured motoneurons and transfected NIH 3T3 cells (2001)

Integrin‐mediated interactions of cells with components of the extracellular matrix (ECM) regulate cell survival, cell proliferation, cell differentiation and cell migration through activation of multiple intracellular signal transduction pathways. In this study, we have demonstrated that integrin–matrix interactions promote KSP tail‐domain phosphorylation of neurofilament medium molecular weight subunits (NF‐M) in cultured rat spinal cord motoneurons and NF‐M transfected NIH 3T3 cells. We found that laminin and fibronectin induce NF‐M tail‐domain phosphorylation in motoneurons and NIH 3T3 cells transfected with NF‐M, respectively. This phosphorylation was selectively inhibited by PD98059, a specific MEK1 inhibitor. This suggests that laminin and fibronectin‐induced MEK1 activation and the downstream targets Erk1 and Erk2 are involved in NF‐M KSP tail‐domain phosphorylation. This pathway appears to represent one of the mechanisms whereby integrin–extracellular matrix interactions are involved in phosphorylation of the NF‐M KSP tail domain.
Experimental Demonstration of Thermally Tunable Fano and EIT Resonances in Coupled Resonant System on SOI Platform (2018)

Thermally tunable Fano and electromagnetically induced transparency (EIT) resonances are theoretically and experimentally demonstrated based on a Mach-Zehnder interferometer assisted Bragg grating-microring coupled resonant system on silicon-on-insulator (SOI) platform. In this paper, the destructive and constructive coupling between the two resonators, the microring resonator and the Fabry-Perot resonator formed by two Bragg gratings, give rise to the Fano and EIT resonances, respectively. The resonance lineshape can be controlled and converted by tuning the optical path length of the MZI arm. The device performance has been theoretically analyzed by using a specially developed numerical model. The coupled resonant system was designed, fabricated, and characterized on a commercial (SOI) platform. The tuning and conversion of the resonance lineshape by thermo-optical effect have been experimentally observed and verified, with good agreement between the experimental data and the simulations.