gebhart/patrepeval huggingface dataset:
Ultrafast Pulse Compression in Bulk with > 20 Times Spectral Broadening Factor from a Single Stage (2021)

We introduce the combination of multi-pass cell and multi-plate spectral broadening. We demonstrate the compression of 110-μJ pulses from 900-fs to 60-fs in a single stage and report broadening to 38-fs transform-limit by nonlinear mode-matching.
Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons (2021)

Neurons undergo substantial morphological and functional changes during development to form precise synaptic connections and acquire specific physiological properties. What are the underlying transcriptomic bases? Here, we obtained the single-cell transcriptomes of <i>Drosophila</i> olfactory projection neurons (PNs) at four developmental stages. We decoded the identity of 21 transcriptomic clusters corresponding to 20 PN types and developed methods to match transcriptomic clusters representing the same PN type across development. We discovered that PN transcriptomes reflect unique biological processes unfolding at each stage-neurite growth and pruning during metamorphosis at an early pupal stage; peaked transcriptomic diversity during olfactory circuit assembly at mid-pupal stages; and neuronal signaling in adults. At early developmental stages, PN types with adjacent birth order share similar transcriptomes. Together, our work reveals principles of cellular diversity during brain development and provides a resource for future studies of neural development in PNs and other neuronal types.
Stent-grafts versus drug-eluting stents in arterial aneurysms, insights from the International Coronary Artery Aneurysm Registry (CAAR) (2021)

ABSTRACT Introduction and objectives: Coronary artery aneurysms are a complex situation. Our main objective is to describe the frequency of use of covered stents (grafts) for their management, as well as to characterize their long-term results compared to drug-eluting stents. Methods: Ambispective observational study with data from the International Coronary Artery Aneurysm Registry (CAAR) (NCT-02563626). Only patients who received a stent-graft or a drug-eluting stent where the aneurysm occurred were selected. Results: A total of 17 patients received, at least, 1 stent-graft while 196 received 1 drug-eluting in the aneurysmal vessel. Male predominance, a higher rate of dyslipidemia, a past medical history of coronary artery disease, previously revascularized coronary artery disease, and giant aneurysms were reported in the stent-graft cohort. The independent predictive variables of the composite endpoint of all-cause mortality, heart failure, unstable angina, reinfarction, stroke, systemic embolism, bleeding or any aneurysmal complications at the median follow-up of 38 months were suggestive of the existence of connective tissue diseases (HR, 5.94; 95&#x0025;CI, 1.82-19.37), left ventricular dysfunction &#x2264; 55&#x0025; (HR, 1.84; 95&#x0025;CI, 1.09-3.1), and an acute indication for heart catheterization (HR, 2.98; 95&#x0025;CI, 1.39-6.3). The use of stent-grafts was not associated with the occurrence of more composite endpoints (23.5&#x0025; vs 29.6&#x0025;; P = .598). Conclusions: The use of stent-grafts to treat coronary aneurysms is feasible and safe in the long-term. Randomized clinical trials are needed to decide what the best treatment is for these complex lesions. Keywords: Coronary aneurysm. Registry. Stent. Stent graft. Angioplasty.
Supplementary Data: Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (ulixertinib) from Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) (2023)

&lt;p&gt;Supplementary materials and methods and supplementary figure legends&lt;/p&gt;
Low-power programmable-logic cell arrays using nonvolatile complementary atom switch (2014)

Programmable-logic cell that utilizes complementary atom switch (CAS) is fabricated using <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">65</i> -nm node CMOS process. A 16-bit ALU is implemented and demonstrated on a 24×24 programmable-logic cell array including 645kbit CAS for both routing switches and configuration memories. Comparing the conventional cell design using CMOS routing multiplexer (MUX), the proposed programmable-logic cell array performs 60% active power saving and 3 times faster operation.
EDL-360: A Potential Novel Antiglioma Agent (2014)

Glioma is a brain tumor that arises from glial cells or glial progenitor cells, and represents 80% of malignant brain tumor incidence in the United States. Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor malignancy with fewer than 8% of patients with GBM surviving for more than 3 years. Over the past 10 years, despite improvement in diagnosis and therapies for cancer, the survival rate for high-grade glioma patients remains dismal. The main focus of our research is to identify potent novel antiglioma small molecules. We previously showed that EDL-360, a tetrahydroisoquinoline (THIQ) analog, as being highly cytotoxic to human glioma cell cultures. Here we show that EDL-360 significantly induced apoptosis in human glioma cell lines (U87 and LN18). However, in normal astrocytic cells, EDL-360 induced a modest G0/G1 cell cycle arrest but did not induce apoptosis. In an attempt to enhance EDL-360 induced cell death, we tested simultaneous treatment with EDL-360 and embelin (an inhibitor of the anti-apoptotic protein, XIAP). We found that, glioma cells had significant lower viability when EDL-360 and embelin were used in combination when compared to EDL-360 alone. We also used combination treatment of EDL-360 with decylubiquinone (dUb), a caspase-9 inhibitor, and found that the combination treatment induced a significant cell death when compared to treatment with EDL-360 alone. This is the first report that suggests that dUb has anticancer activity, and perhaps acts as a XIAP inhibitor. Finally, our <i>in vivo</i> data showed that EDL-360 treatment induced a partial regression in glioma tumorigenesis and induced cell death in the treated tumors as shown by H&E staining. Taken together these data suggests that EDL-360 has a potential therapeutic application for treating glioma, especially when combined with XIAP inhibitors.
High fidelity biopotential recordings in mice using a novel telemetry implant (2015)

We have developed a fully implantable telemetry device for use in mice. The telemeter is able to measure biopotential signals (EEG, EMG, ECG) at a sampling rate of 2000 Hz. The device has a volume of 1.45 cc with a unique contour design for subcutaneous implantation in mice over 20 gm in weight. A novel aspect to the device is that it contains no battery. Power to run the telemeter is provided by a wireless power pad placed under the cage of the animal. This provides continual operation of the telemeter (&gt;90% data collection in a 24 hour period) during a range of normal animal behaviours. We have assessed the ability of this device to record biopotential signals for up to 3 months. We believe this technology offers new experimental paradigms to be explored.
Stable Triazenes Derived from 2‐Alkylaminonaphthalenes and 5‐Nitrobenzo[c]‐1,2‐thiazole‐3‐diazonium Hydrogensulfate (2008)

Abstract A calculation using the DFT method confirmed that the extraordinary stability of the triazenes formed by an azo coupling reaction of 5‐nitrobenzo[ c ]‐1,2‐thiazole‐3‐diazonium with primary or secondary aromatic amines is caused by the fact that these substances are protonated at the heterocyclic nitrogen atom and not at the nitrogen atom of the triazene grouping –N=N–N(R)Ar. Stable triazenes are also formed by reaction of 5‐nitrobenzo[ c ]‐1,2‐thiazole‐3‐diazonium with 2‐alkylaminonaphthalenes. In the cases of the azo coupling reaction with 2‐methylamino‐ and 2‐ethylaminonaphthalene, the content of triazenes is almost 50 % in the product mixture with the isomeric azo compounds. The structures of the triazenes were confirmed by X‐ray analysis.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Footprint and feature management using aspect-oriented programming techniques (2002)

Applications accrue features in response to the needs of all users, yet the associated code bloating and performance loss often render an application unsuitable for some users, particularly those interested in using the application in an embedded system. As a result, developers are often faced with either reinventing pieces of an application, custom tailored to their needs, or they are faced with the daunting task of refactoring an existing application to obtain an appropriate subset of that application's functionality. In either case, subsequent development, maintenance and testing of the application becomes more complex, due to the effects of future revisions on all of the derived subsets.In this paper, we report on our experience in obtaining subsets of an application's functionality, using a relatively new programming-language paradigm and tool to achieve the subsets compositionally. Instead of refactoring a large, feature-rich application, a feature can be added by including that feature's aspect in the set provided to an aspect compiler. In particular, a minimal, base implementation was developed in Java and features were added by supplying the appropriate advice to an AspectJ compiler. We describe our approach and present footprint and performance results for automatically derived subsets of an event channel .
Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge (2020)

We compare immunogenicity and protective efficacy of an HIV vaccine comprised of env and gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in the same muscles or by separate administration of DNA + protein in contralateral sites in female rhesus macaques. The 6-valent vaccine includes gp145 Env DNAs, representing six sequentially isolated Envs from the HIV-infected individual CH505, and matching GLA-SE-adjuvanted gp120 Env proteins. Interestingly, only macaques in the co-administration vaccine group are protected against SHIV CH505 acquisition after repeated low-dose intravaginal challenge and show 67% risk reduction per exposure. Macaques in the co-administration group develop higher Env-specific humoral and cellular immune responses. Non-neutralizing Env antibodies, ADCC, and antibodies binding to FcγRIIIa are associated with decreased transmission risk. These data suggest that simultaneous recognition, processing, and presentation of DNA + Env protein in the same draining lymph nodes play a critical role in the development of protective immunity.
Isolation, Characterization, and Antimicrobial Properties of Bovine Oligosaccharide-binding Protein (2002)

Peptidoglycan recognition proteins (PGRPs) constitute a recently characterized family of pattern-recognition molecules that are conserved from insects to humans and are implicated in mammalian innate immunity. Here we report the isolation, characterization, cDNA cloning, and antimicrobial activities of a bovine PGRP ortholog termed bovine oligosaccharide-binding protein (bOBP). Milligram quantities of bOBP were purified from peripheral leukocytes, thus allowing for the characterization of the disulfide array and for determining the in vitro antimicrobial activities of the native protein. Of the tissues analyzed, bOBP mRNA was detected only in bone marrow where the protein is synthesized as a 190 amino acid precursor. The mature 169 amino acid protein is stored in the cytoplasmic granules of neutrophils and eosinophils but is absent from lymphocytes, monocytes, and platelets. bOBP was microbicidal for Gram-positive and Gram-negative bacteria and yeast at low micromolar concentrations. The finding that bOBP was microbicidal for organisms in which peptidoglycan is absent (Cryptococcus neoformans) or buried (Salmonella typhimurium) indicates that previous conclusions about the specificity of peptidoglycan recognition proteins must be reevaluated and suggests that other envelope components may mediate the antimicrobial action of PGRP family members.
High-Efficiency Phosphorescent OLEDs using Chemically Doped Layers (2005)

Organic light-emitting devices (LEDs) were fabricated using wide-energy-gap (over 3.30 eV) materials and fac-tris(2-phenylpyridine) iridium complex (Ir(ppy)3) as the carrier transporting materials and the emitting material, respectively. The organic layers at the electrode interfaces were chemically doped to reduce operating voltage. The p-type and n-type doped layers have specific resistance of 105∼106 ω [SW1]·cm. The device exhibited green emission peaking at approximately 510 nm, and the external quantum efficiency of 19.7% (69 cd/A). A high power efficiency of 68 lm/W was observed at 100 cd/m2 at voltage of 3.22 V.
Towards more paper-like input (2008)

This paper presents Foldable User Interfaces (FUI), a combination of a 3D GUI with windows imbued with the physics of paper, and Foldable Input Devices (FIDs). FIDs are sheets of paper that allow realistic transformations of graphical sheets in the FUI. Foldable input devices are made out of construction paper augmented with IR reflectors, and tracked by computer vision. Window sheets can be picked up and flexed with simple movements and deformations of the FID. FIDs allow a diverse lexicon of one-handed and two-handed interaction techniques, including folding, bending, flipping and stacking. We show how these can be used to ease the creation of simple 3D models, but also for tasks such as page navigation.
The Use of Cultured Autologous Oral Epithelial Cells for Vaginoplasty in Male-to-Female Transsexuals (2013)

Various vaginoplasty methods in male-to-female transsexuals have been described, but none is ideal. The use of cultured autologous oral epithelium to cover the neovagina walls is presented. Six patients were operated on. Complications encountered were one case of low-located rectovaginal fistula that was treated conservatively; one case of partial glans necrosis resulting in a scarred but sensitive clitoris; one case of large labia majora requiring reduction; and one case of short vagina requiring surgical revision with autologous cultured oral cells that was successful. All patients had adequate vagina, experienced sexual intercourse, and were satisfied with results. Autologous cultured oral epithelium transplantation is feasible, safe, and advantageous. Satisfactory neovaginas were provided; the procedure is relatively easy to perform and provides a thin, mucosa-lined neovagina with a sufficient amount of secretion.
Quality-driven bitrate adaptation method for HTTP live-streaming (2015)

In this paper, we focus on the bitrate adaptation issue of HTTP live video streaming. We first present a systematic approach that enables the client to choose the best video quality when deciding video bitrate for next several segments. After that, based on the concept of JND (Just Noticeable Difference), an adaptation method is proposed to meet the tradeoff between the requirements of buffer stability and smooth video quality. The experiment results show that our proposed method can provide smooth videos in terms of perceptual quality even under a small buffer size (i.e. 10s). To the best of our knowledge, this paper presents for the first time the way to use a perceptual quality metric for adaptivity in HTTP streaming.
Computer Assisted Tomography of Orbital Lesions in Wegenerʼs Granulomatosis (1978)

The orbital lesions in six patients with Wegener's granulomatosis were studied by computer assisted tomography (CAT). Four patients had active orbital disease and proptosis, and each was found to have orbital masses accompanied by varying degrees of bone and sinus destruction. Two additional patients with histories of proptosis had no orbital lesions at the time of CAT study.
Deactivated CRISPR Associated Protein 9 for Minor-Allele Enrichment in Cell-Free DNA (2017)

The dCas9 method provides an important application of the CRISPR/Cas9 system outside the realm of genome editing and can provide a step forward for the detection capability of cfDNA diagnostics.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis (2019)

The heterodimeric transmembrane αv integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyrate-based antagonists of the vitronectin receptors αvβ3 and αvβ5 significantly change the biological activities against αvβ6 and αvβ8. This resulted in the discovery of a pan αv antagonist (compound <b>39</b>, 4-40 nM for the integrin receptors named above) possessing excellent oral pharmacokinetic properties in rats (with a clearance of 7.6 mL/(min kg) and a bioavailability of 97%).
A Peer-to-Peer Middleware Framework for Resilient Persistent Programming (2010)

The persistent programming systems of the 1980s offered a programming model that integrated computation and long-term storage. In these systems, reliable applications could be engineered without requiring the programmer to write translation code to manage the transfer of data to and from non-volatile storage. More importantly, it simplified the programmer's conceptual model of an application, and avoided the many coherency problems that result from multiple cached copies of the same information. Although technically innovative, persistent languages were not widely adopted, perhaps due in part to their closed-world model. Each persistent store was located on a single host, and there were no flexible mechanisms for communication or transfer of data between separate stores. Here we re-open the work on persistence and combine it with modern peer-to-peer techniques in order to provide support for orthogonal persistence in resilient and potentially long-running distributed applications. Our vision is of an infrastructure within which an application can be developed and distributed with minimal modification, whereupon the application becomes resilient to certain failure modes. If a node, or the connection to it, fails during execution of the application, the objects are re-instantiated from distributed replicas, without their reference holders being aware of the failure. Furthermore, we believe that this can be achieved within a spectrum of application programmer intervention, ranging from minimal to totally prescriptive, as desired. The same mechanisms encompass an orthogonally persistent programming model. We outline our approach to implementing this vision, and describe current progress.
Can developer-module networks predict failures? (2008)

Software teams should follow a well defined goal and keep their work focused. Work fragmentation is bad for efficiency and quality. In this paper we empirically investigate the relationship between the fragmentation of developer contributions and the number of post-release failures. Our approach is to represent developer contributions with a developer-module network that we call contribution network. We use network centrality measures to measure the degree of fragmentation of developer contributions. Fragmentation is determined by the centrality of software modules in the contribution network. Our claim is that central software modules are more likely to be failure-prone than modules located in surrounding areas of the network. We analyze this hypothesis by exploring the network centrality of Microsoft Windows Vista binaries using several network centrality measures as well as linear and logistic regression analysis. In particular, we investigate which centrality measures are significant to predict the probability and number of post-release failures. Results of our experiments show that central modules are more failure-prone than modules located in surrounding areas of the network. Results further confirm that number of authors and number of commits are significant predictors for the probability of post-release failures. For predicting the number of post-release failures the closeness centrality measure is most significant.
Defect and Surface Area Control in Hydrothermally Synthesized LiMn0.8Fe0.2PO4 Using a Phosphate Based Structure Directing Agent (2015)

As confirmed by ion coupled plasma-optical emission spectroscopy and powder X-ray diffraction, stoichiometrically pure samples of olivine type LiFe0.2Mn0.8PO4 in the presence of a phosphoric acid ester based structure directing agent have been prepared. A Rietveld analysis of X-ray and n0 diffraction data suggests that the solids are largely free of defect occupation of Fe at the lithium sites. This is confirmed by 57Fe-Mößbauer spectroscopic investigations. The use of the structure directing surfactant results in significantly higher specific surface areas (SSA) and smaller particle sizes as compared to samples prepared without using a surfactant.
[Activation of oncogenes by chemical modification with carcinogens]. (1986)

This article reviews the chemical modification of DNA (mainly proto-Ha-ras sequence) which causes mutation and induction of transforming activity. An initial chemical event caused by chemical carcinogens is modification of DNA with metabolically activated carcinogens. The chemical modification of DNA is thought to result in activation of oncogenes by mutation or reconstruction. The activated transforming oncogenes (mainly of the ras family, by point mutation) have been found in tumors induced by diverse carcinogens in vivo (reviewed briefly). Recently, results establishing that chemical modification of proto-oncogenes with carcinogens, such as benz (a) pyrene, acetylaminofluorene, Glu-P-1, 4NQO, and aflatoxin B1, induces transforming activity of the gene when transfected into NIH3T3 cells have been reported. The mechanism of activation of proto-Ha-ras by chemical modification has been investigated by RFLP (restriction fragment length polymorphism) assay and/or Southern blot analysis using synthetic oligonucleotides. Point mutations at codon 12 or 61 have been found. The correlation between the established chemistry of chemical modification of DNA with diverse carcinogens and activation of proto-oncogenes is discussed.
The European Project 20plµs: 20 Percent Efficiency on Less Than 100µm Thick Industrially Feasible Crystalline-Si Solar Cells (2012)

The European project 20plμs is developing Si wafer solar cells with efficiencies above 20% on wafers less than 100 μm thick. Three principal solar cell process routes are investigated. The three approaches are distinguished by the doping type and maximum process temperature: p-type monocrystalline Cz-Si and multicrystalline Si solar cells subjected to high temperature processes are called pht, and n-type Cz-Si cells fabricated with low and high temperature processes are called nlt and nht, respectively. Already at the project’s midterm, a particular pht solar cell process was transferred to pilot line production. Key issues such as wafering, surface passivation, light trapping, metallisation and life cycle analysis were tackled to determine which process should be transferred. To date, by integrating the processes investigated within the project into full solar cells, efficiencies up to 18.7% (pht), 19.0% (nht) and 20.8% (nlt, 4 cm2) have been achieved on 100 μm thick large area Si wafers.