gebhart/patrepeval huggingface dataset:
Zzyzx: Scalable fault tolerance through Byzantine locking (2010)

Zzyzx is a Byzantine fault-tolerant replicated state machine protocol that outperforms prior approaches and provides near-linear throughput scaling. Using a new technique called Byzantine Locking, Zzyzx allows a client to extract state from an underlying replicated state machine and access it via a second protocol specialized for use by a single client. This second protocol requires just one round-trip and 2 f + 1 responsive servers-compared to Zyzzyva, this results in 39-43% lower response times and a factor of 2.2-2.9× higher throughput. Furthermore, the extracted state can be transferred to other servers, allowing non-overlapping sets of servers to manage different state. Thus, Zzyzx allows throughput to be scaled by adding servers when concurrent data sharing is not common. When data sharing is common, performance can match that of the underlying replicated state machine protocol.
Comparative Study on the Cryoprotective Effects of Three Recombinant Antifreeze Proteins from Pichia pastoris GS115 on Hydrated Gluten Proteins during Freezing (2018)

During the freezing process, ice crystal formation leads to the deterioration in physicochemical properties and networks of gluten proteins. The cryoprotective effects of recombinant carrot ( Daucus carota) antifreeze protein (rCaAFP), type II antifreeze protein from Epinephelus coioides (rFiAFP), and Tenebrio molitor antifreeze protein (rTmAFP) produced from Pichia pastoris GS115 on hydrated gluten, glutenin, and gliadin during freezing were investigated. The thermal hysteresis (TH) activity and ice crystals' morphology modification ability of recombinant antifreeze proteins (rAFPs) were analyzed by differential scanning calorimetry (DSC) and cryomicroscope, respectively. The freezing and melting properties, water state, rheological properties, and microstructure of hydrated gluten proteins were studied by DSC, low field nuclear magnetic resonance, rheometer, and scanning electron microscopy, respectively. The rTmAFP exhibited strongest TH activity and ice crystals' morphology modification ability, followed by rFiAFP and rCaAFP. The addition of the three rAFPs caused freezing hysteresis and weakened the damage of freezing to the networks of hydrated gluten, glutenin, and gliadin. During freezing, the cryoprotective effects of the three rAFPs on the freezable water content, water mobility and distribution, and rheological properties of hydrated gluten were achieved by protecting these corresponding properties of hydrated glutenin. Among the three rAFPs, rTmAFP was most effective in the cryoprotective activities on hydrated gluten proteins during freezing. The results demonstrate the potential of these rAFPs, especially rTmAFP, to preserve the above properties of hydrated gluten proteins during the freezing process.
Atomic snapshots of shared memory (1990)

An atomic snapshot memory is a shared data structure allowing concurrent processes to store information in a collection of shared registers, all of which may be read in a single atomic scan operation. This paper presents three wait-free implementations of atomic snapshot memory. Two constructions implement wait-free single-writer atomic snapshot memory from wait-free atomic single-writer, n-reader registers. A third construction implements a wait-free n-writer atomic snapshot memory from n-writer, n-reader registers.
Stent-Graft Placement for the Treatment of Thoracic Aortic Diseases (2005)

The recent development of aortic stent-grafts has brought the management of thoracic aortic diseases into the realm of interventional radiology. Stent-graft placement is now an alternative to surgery for the treatment of descending thoracic aortic aneurysms, ulcers, and fistulas and is sometimes indicated in cases of mycotic aneurysm, posttraumatic aortic rupture, or thoracic descending aortic dissection. Pretreatment imaging is crucial for evaluating patient eligibility, selecting the appropriate stent-graft, and planning the intervention. Stent-graft treatment of long atherosclerotic aneurysms, lesions close to aortic branch vessels, and aortic dissections is subject to technical pitfalls, and adverse events such as endoleaks, stent migration or misplacement, aortic perforation, and vascular trauma will require specific interventions, although they occur in only a minority of patients. Thoracic stent-graft placement in good surgical candidates remains controversial because long-term results are unknown. However, short-term morbidity and mortality rates from endovascular treatment compare favorably with those from surgery, and stent-graft placement is proving to be a safe, minimally invasive, and effective treatment for thoracic aortic diseases and is already the best option in many affected patients who are poor surgical candidates.
Evolutionary computer vision (2009)

tutorial Share on Evolutionary computer vision Authors: Mengjie Zhang Victoria University of Wellington, Wellington, New Zealand Victoria University of Wellington, Wellington, New ZealandView Profile , Stefano Cagnoni University of Parma, Parma, Italy University of Parma, Parma, ItalyView Profile , Gustavo Olague CICESE Research Center, Ensenada, Mexico CICESE Research Center, Ensenada, MexicoView Profile Authors Info & Claims GECCO '09: Proceedings of the 11th Annual Conference Companion on Genetic and Evolutionary Computation Conference: Late Breaking PapersJuly 2009 Pages 3355–3380https://doi.org/10.1145/1570256.1570423Online:08 July 2009Publication History 3citation309DownloadsMetricsTotal Citations3Total Downloads309Last 12 Months14Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Tissue Kallikrein-binding Protein Reduces Blood Pressure in Transgenic Mice (1996)

The kallikrein-kinin system participates in blood pressure regulation. One of the kallikrein-kinin system components, kallikrein-binding protein, binds to tissue kallikrein and inhibits its activity in vitro. To investigate potential roles of rat kallikrein-binding protein (RKBP) in vivo, we have developed transgenic mice that express an RKBP gene under the control of the mouse metallothionein metal-responsive promoter. Expression of the transgene, RKBP, was detected in the liver, kidney, lung, heart, pancreas, salivary glands, spleen, brain, testis, and adrenal gland at the mRNA and protein levels. Systolic blood pressures of homozygous transgenic mice were 88.5 +/- 0.8 mm Hg (mean +/- S.E., n = 19, P < 0.001) for one line and 88.8 +/- 1.6 mm Hg (mean +/- S.E., n = 19, P < 0.001) for another, as compared with 100.5 +/- 0.8 mm Hg (mean +/- S.E., n = 18) for control mice. Direct blood pressure measurements of these transgenic mice through an arterial cannula showed similar reductions of blood pressure. Intravenous injection of purified RKBP into mice via a catheter produced a dose-dependent reduction of the mean arterial blood pressure. Our findings suggest that RKBP may function as a vasodilator in vivo, independent of regulating the activity of tissue kallikrein.
Voice over Wireless LAN via IEEE 802.16 Wireless MAN and IEEE 802.11 Wireless Distribution System (2005)

Today, IEEE 802.11 wireless LANs (WLAN) have been widely deployed to provide wireless broadband access in local areas such as campuses or offices. Most of the WLANs are connected to the backbone via a wired distribution system (DS). IEEE 802.16 wireless MANs (WMAN) aim to extend the wireless broadband access up to kilometers to facilitate the long-range "last-mile" solution. For short-range extension, IEEE 802.11 wireless distribution system (WDS) can be set up easily by connecting access points (AP) together to form multi-hop networks. This provides a quick, easy and low-cost solution up to hundreds meters. In this paper, we exam the capacity challenges in delivering voice traffic over WLANs which are connected to 1) IEEE 802.16 WMAN and 2) IEEE 802.11 WDS. For 1), we show that the capacity is limited by the WLAN bottleneck and we propose a multiplex-multicast (M-M) scheme to double the capacity. For 2), we show that the M-M scheme should also be adopted in WDS. This scheme can sufficiently improve the voice capacity up to 7 times (from 3 to 22 voice sessions) in a 4-hop WDS. To verify our simulation results in Ng, P.C. et al, (2005), we set up a real multi-hop WDS. Experimental measurements confirm that our proposed scheme can increase both the voice capacity and service coverage of WDS.
Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: clinical and imaging patterns (2015)

OBJECT Perineural spread along pelvic autonomie nerves has emerged as a logical, anatomical explanation for selected cases of neoplastic lumbosacral plexopathy (LSP) in patients with prostate, bladder, rectal, and cervical cancer. The authors wondered whether common radiological and clinical patterns shared by various types of pelvic cancer exist. METHODS The authors retrospectively reviewed their institutional series of 17 cases concluded as perineural tumor spread. All available history, physical examination, electrodiagnostic studies, biopsy data and imaging studies, evidence of other metastatic disease, and follow-up were recorded in detail. The series was divided into 2 groups: cases with neoplastic lumbosacral plexopathy confirmed by biopsy (Group A) and cases included based on imaging characteristics despite the lack of biopsy or negative biopsy results (Group B). RESULTS Group A comprised 10 patients (mean age 69 years); 9 patients were symptomatic and 1 was asymptomatic. The L5-S1 spinal nerves and sciatic nerve were most frequently involved. Three patients had intradural extension. Seven patients were alive at last follow-up. Group B consisted of 7 patients (mean age 64 years); 4 patients were symptomatic, 2 were asymptomatic, and 1 had only imaging available. The L5-S1 spinal nerves and the sciatic nerve were most frequently involved. No patients had intradural extension. Four patients were alive at last follow-up. CONCLUSIONS The authors provide a unifying theory to explain lumbosacral plexopathy in select cases of various pelvic neoplasms. The tumor cells can use splanchnic nerves as conduits and spread from the end organ to the lumbosacral plexus. Tumor can continue to spread along osseous and muscle nerve branches, resulting in muscle and bone "metastases." Radiological studies show a reproducible, although nonspecific pattern, and the same applies to clinical presentation.
A Novel Concept for Advanced Modules with Back-Contact Solar Cells (2010)

Imec has developed a new technology concept to integrate and interconnect back-contact solar cells into modules, based on embedding cells in silicone on top of a glass substrate. This so-called i-module (interconnect module) technology aims at an improved optical performance and reliability, combined with an increased throughput for module manufacturing, through the use of silicones and a module-level interconnection that eliminates string handling. One of the additional advantages is that the technology could therefore be suitable for integrating very thin cells into modules. The paper will first elaborate on the process flow, its background and motivation. A lot of options are still open for consideration, but technical feasibility is demonstrated for two distinct implementations. Materials and processing are discussed for these cases, as well as the resulting module measurements. Then the methodology behind the followed reliability approach is discussed on a general level and some first results on accelerated reliability testing and outdoor weathering are shown. Finally, a view on future developments is given as an outlook.
Critical Current Degradation in HTS Wires Due to Cyclic Mechanical Strain (2005)

HTS wires, which may be used in many devices such as magnets and rotating machines, may be subjected to mechanical strains from electromagnetic, thermal and centripetal forces. In some applications these strains will be repeated several thousand times during the lifetime of the device. We have measured critical current degradation due to repeated strain cycles for both compressive and tensile strains. Results for BSCCO-2223 HTS conductor samples are presented for strain values up to 0.5% and cycle numbers up to and beyond 10/sup 4/.
3DIC developments for high yield and reliability manufacturing (2017)

3D-IC has been recognized as one of the technology solutions from More than Moore. Xilinx's 3D-IC FPGA has been well adopted by the industry since the first Virtex®-7 2000T introduced in 2011. In particular recently, data center requires large volume of 3D-IC for its applications. To fulfill the high demand effectively the best way is to provide the high yield and reliability 3D-IC product supply. The authors would like to share Xilinx's 3D-IC development experiences by means of launching process learning vehicles, pursuing early stages reliability assessment, and optimizing the process baseline. All the development efforts paved the foundation for a robust production line. At the end, the potential future 3D-IC technology challenges are outlined.
Characteristics of Polylipid/Hb Vesicles (ARC) (invitroand invivotest:) (1992)

Polylipid/Hb vesicle, which is polymerized phospholipid vesicles (200 nm) encapsulating concentrated Hb solution, has been established by us as an artificial red cell (ARC). ARC can be easily adjusted to physiological conditions (viscosity, density and oncotic pressure etc) as the same of human blood. Our ARC has excellent blood compatibility (no effect on coagulation, no hemolysis and no red cell aggregation). Neither acute toxicity nor damage of internal organs was confirmed. Oxygen transporting capacity was almost the same as human blood, and the half life in blood stream was ca. 13 hrs.
DNA concentration wave formation in pillar arrays (2020)

High throughput in particle and molecular sorting schemes is an important performance indicator and can be realized through increased volumetric processing rates or increased concentrations. Here we investigate the effect of increased concentration of high-molecular weight DNA in micropillar arrays for deterministic lateral displacement (DLD). We find that the array imposes regular fluctuations in the concentration of the DNA if the sample concentration and flow rates exceed respective threshold values. We characterize the resulting concentration waves and study their influence on microsphere trajectories in the device. We expect our results to be relevant e.g. for sample preparation of cell lysates which can often be complicated by the release of chromosomal DNA.
[Feasibility study of CdTe Semiconductor detector for gamma camera--evaluation of planar images]. (2000)

To evaluate the performance of a semiconductor detector for use in a gammacamera system, we assembled a detector with a small field of view--1 inch x 1 inch and 1 inch x 2 inch--made from CdTe (Cadmium telluride). We then compared the planar images and energy resolution of the resulting detectors against those of a conventional gammacamera. Pixel pitch of the detector was 1.6 mm x 1.6 mm, and was manufactured by Acrorad Corporation. Average FWHM of the energy spectrum for the semiconductor detector was 5.11% (SD: 0.80%, Best: 3.26%, Worst: 6.68%). The planar images obtained were of a letter phantom made from pieces of lead and of an IMP brain phantom. Since the field of view of the semiconductor detector was small, the image of the IMP brain phantom was acquired by moving the semiconductor over the collimated detector module until the area of the entire phantom was covered. The images from the semiconductor assembly were compared with those from a conventional gammacamera using the same conditions, and it was found that visual image quality was superior to those of the conventional camera system.
Polypivalolactone–Carbon Fiber CompositesAdapted fromPolypivalolactone‐Carbon Fiber Composites, First Edition. (2012)

Abstract In this article polypivalolactone ‐ carbon fiber composites are presented. In particular the crystallinity of polypivalolactone (PPL) is higher than that of polyetherether ketone (PEEK)or polyphenylene sulfide (PPS) and this high value leads to far better strength, stiffness, solvent resistance, and temperature resistance than would be expected of a simple aliphatic polyester. This article describes techniques for prepregging PPL‐carbon and the mechanical properties of PPL‐carbon composites. Moreover a comparison between mechanical properties of PPL‐carbon composites with PEEK and PPS composites, and a comparison between the solvent resistance of PPL and PEEK neat resins are discussed.
Implementing a new naming system for IP mobility called SING (2003)

The Internet today may not support a sufficiently high degree of freedom and mobility the users request. The fundamental problem is in the design of the network layer of the Internet stack, whi ...
26 THE USE OF PAIRED CRISPR GUIDE RNAs AND THE Cas9 SYSTEM DOES NOT ALWAYS PRODUCE SITE SPECIFIC DELETIONS OF GENE SEQUENCE IN PORCINE CELL AND EMBRYO CULTURE (2016)

The use of the CRISPR/Cas9 system has become increasingly popular for creating gene edits in both cell and embryo culture. High specificity and efficiency of editing as well as low cost and ease of use has helped to promote its use. We hypothesised that by using multiple CRISPR guides at one time, we could quickly create exact deletions spanning greater areas of sequence. A total of 5 candidate genes (A, B, C, D, E) were targeted for deletions ranging in size of 74 to 551 bp. All modifications were created through the co-injection of 2 CRISPR guide RNAs with Cas9 RNA into in vitro-produced presumptive porcine zygotes. The CRISPR guides were created using gBlocks containing the T7 promoter sequence, 18–24 bp of CRISPR guide RNA, and 85 bp of tracer RNA. The RNA structure of each guide was reviewed using RNA Folding Form as well as offsite cutting using NCBI Blast. CRISPR guide RNA pairs (20 ng µL-1) and Cas9 RNA (20 ng µL-1) were co-injected (1–3 ?l) into the cytoplasm of IVF produced porcine zygotes using the FemtoJet 4i injector. Following injections, the zygotes were cultured in vitro for 5–6 days, and viable blastocyst or morula were selected for embryo transfer into recipient gilts. Resulting pigs were assayed for expected modifications using PCR. Pigs were considered modified if an insertion or deletion was measured by gel electrophoresis and DNA sequencing. Only one pair of CRISPR guides was injected per zygote, resulting in an individual PCR assay for the gene of interest. In total, 42 live piglets were born, 24 of which were edited, yielding 57% modification. When expected modifications v. observed were analysed, only 4 of 24 pigs (16%) produced the predicted modification on at least one allele. Of the remaining 20 pigs, several showed more than one form of modification. Insertions of ranging from 1 to 400 bp were detected in 10 pigs, 9 pigs formed biallelic modifications, 6 pigs produced altered sequence for greater than 2 alleles (mosaic), 6 pigs had deletions larger than the expected ranging from 11 to 1739 bp, and 14 had deletions smaller than the expected. Due to the absence of plasmid during injections, the insertions observed contained repetitive elements from the gene being modified as well as random additional bases. Additionally, CRISPR pairs were used in cell culture of porcine fibroblast modifying gene F, where they produced 6 different deletions ranging from the expected 63b to 617 bp. We recognise that the cutting efficiency of each CRISPR guide was not measured, as our goal was to create the expected deletions from pairs of CRISPR guides. We acknowledge our hypothesis was incorrect, as this data indicates that the CRISPR/Cas9 system is a very useful tool for gene editing, however it can induce unexpected modifications when used in pairs, in cell and embryo culture. Study was supported by funding from Food for the 21st Century and NIH (U42OD011140).
Radial Artery Tonometry to Monitor Blood Pressure and Hemodynamics in Ambulatory Left Ventricular Assist Device Patients in Comparison With Doppler Ultrasound and Transthoracic Echocardiography: A Pilot Study (2018)

Noninvasive measurements of blood pressure (BP) and cardiac output (CO) are crucial in the follow-up of continuous-flow left ventricular assist device (CF-LVAD) patients. For our pilot study, we sought to compare BP measurements between a tonometry blood pressure pulse analyzer (BPPA) (DMP-Life, DAEYOMEDI Co., Ltd., Gyeonggi-do, South Korea) and Doppler ultrasound in CF-LVAD patients, as well as to compare the BPPA estimated CO to LVAD calculated blood flow and to the patient's intrinsic CO estimated with transthoracic echocardiography (TTE). Ambulatory CF-LVAD patients (6 HeartMate, 26 HeartMate II), were included. According to TTE findings, patients were then subdivided in two groups: patients with an opening aortic valve (OAV) [n = 21] and those with an intermittent opening aortic valve (IOAV) [n = 11]. We found a very good correlation of systolic BP (SBP) measurements between the two methods, BPPA and Doppler ultrasound (r = 0.87, P < 0.0001). Bland-Altman plots for SBP revealed a low bias of -4.6 mm Hg and SD of ±4.7 mm Hg. In CF-LVAD patients with IOAV, the BPPA-CO had a good correlation with the LVAD-flow (r = 0.78, P < 0.0001), but in OAV patients, there was no correlation. After adding the patient's intrinsic CO, estimated from TTE in patients with OAV to the LVAD-flow, we found a very good correlation between the BPPA-CO and LVAD-flow + TTE-CO (r = 0.81, P = 0.002). Our study demonstrated that compared with the standard clinical method, Doppler ultrasound, the BPPA measured BP noninvasively with good accuracy and precision of agreement. In addition, tonometry BPPA provided further valuable information regarding the CF-LVAD patient's intrinsic CO.
An American Engineer in Stalin's Russia: The Memoirs of Zara Witkin, 1932-1934. (1992)

Journal Article An American Engineer in Stalin's Russia: The Memoirs of Zara Witkin, 1932–1934. Ed. by Michael Gelb. (Berkeley: University of California Press, 1991. x + 363 pp. $29.95, ISBN 0-520-07134-4.) Get access Fraser Ottanelli Fraser Ottanelli University of South Florida, Tampa Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 79, Issue 2, September 1992, Page 711, https://doi.org/10.2307/2080156 Published: 01 September 1992
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains (2020)

Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions and is generated by systematic yeast two-hybrid interaction screening of ∼500 ND-related proteins and integration of literature interactions. This network reveals interconnectivity across diseases and links many known ND-causing proteins, such as α-synuclein, TDP-43, and ATXN1, to a host of proteins previously unrelated to NDs. It facilitates the identification of interacting proteins that significantly influence mutant TDP-43 and HTT toxicity in transgenic flies, as well as of ARF-GEP<sub>100</sub> that controls misfolding and aggregation of multiple ND-causing proteins in experimental model systems. Furthermore, it enables the prediction of ND-specific subnetworks and the identification of proteins, such as ATXN1 and MKL1, that are abnormally aggregated in postmortem brains of Alzheimer's disease patients, suggesting widespread protein aggregation in NDs.