gebhart/patrepeval huggingface dataset:
MMP activation peptide detection in biological samples as a diagnostic marker of idiopathic pulmonary fibrosis (2009)

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown etiology. Historically, IPF has been seen as a gradually progressive disease. However some patients with IPF experience acute exacerbations of IPF characterized by a rapid deterioration of lung function and accelerated death. Matrix metalloproteases (MMPs) are a family of proteases that regulate extracellular matrix turnover. Some MMPs have been shown to be upregulated in IPF and these MMPs are thought to directly contribute to disease progression. MMPs are proteases that are subject to inhibition once activated. The inhibited complexes are rapidly cleared preventing accurate biological detection of MMP activation. In contrast, the mechanism of clearance of the activation peptides released from the MMPs is unknown. ELISA experiments show that the activation peptides of MMP2, MMP7, and MMP9 are elevated in the urine of mice with pulmonary fibrosis compared to WT mice and in the urine of human patients with IPF compared to healthy controls. These data suggest that urine detection of MMP activation peptides is feasible and correlates with disease. Because MMP activation contributes to disease initiation and progression, we hypothesize that the accurate detection of the activation of these proteases will be relevant clinically and may allow for earlier detection of disease as well as allow for prediction of acute exacerbations.
Combined treatment of psoriasis with a new aromatic retinoid (Tigason) in low dosage orally and triamcinolone acetonide cream topically: a double-blind trial (1980)

In a multicentre double-blind trial the effect of three therapy regimens was studied for 6 weeks in ninety psoriasis patients: (1) aromatic retinoid (Ro 10-9359) orally (0.50-0.66 mg/kg body weight) and placebo cream topically; (2) aromatic retinoid (Ro 10-9359) (same dosage) with 0.1% triamcinolone acetonide and 5% salicylic acid in lanette wax cream; (3) placebo capsules with 0.1% triamcinolone acetonide and 5% salicylic acid in lanette wax cream. Regimen 1 had virtually no effect and regimen 2 gave better results than regimen 3 for almost all parameters, although statistical significance was reached for only some of them. The 6 week double-blind period was followed by an open study in which all patients were treated according to regimen 2. The clinical result could be maintained up to the end of the study (18 weeks), when more than 60% of the patients showed good to excellant (80-100%) improvement. Most of the side-effects of retinoid were mild and relatively rare. It is concluded that the combination of the aromatic retinoid (Ro 10-9359) given in low dosage orally with corticosteroids topically is as effective as therapy with the retinoid in high dosage alone, but with markedly less side-effects.
Even more efficient quantum computations of chemistry through tensor hypercontraction (2020)

Data and code repository for "Even more efficient quantum computations of chemistry through tensor hypercontraction"
An Efficient Hierarchical Fuzzy Approach for System Level System-on-a-Chip Design (2006)

One of the most important bottleneck in the overall design flow of a complex embedded system is due to the simulation. Simulation occurs at every phase of the design flow. In this paper we focus on system level design proposing a novel approach to speed up the evaluation of a system configuration. The approach, which uses a fuzzy system as approximator for the different components of the system, is used to accelerate the design space exploration of a VLIW based parameterized SoC platform for the optimization of both performance and power dissipation. The experiments carried out on a multimedia benchmark suite, demonstrate the scalability and the accuracy of the proposed approach
Discrimination of Complete Hydatidiform Mole From Its Mimics by Immunohistochemistry of the Paternally Imprinted Gene Product p57 KIP2 (2001)

The p57KIP2 protein is a cell cycle inhibitor and tumor suppressor encoded by a strongly paternally imprinted gene. We explored the utility of p57KIP2 as a diagnostic marker in hydatidiform mole, a disease likely the result of abnormal dosage and consequent misexpression of imprinted genes. Using a monoclonal antibody on paraffin-embedded, formalin-fixed tissue sections, the authors evaluated p57KIP2 expression in normal placenta and in 149 gestations including 59 complete hydatidiform moles, 39 PHMs, and 51 spontaneous losses with hydropic changes. p57KIP2 was strongly expressed in cytotrophoblast and villous mesenchyme in normal placenta, all cases of partial hydatidiform moles (39 of 39) and all spontaneous losses with hydropic changes (51 of 51). In contrast, p57KIP2 expression in cytotrophoblast and villous mesenchyme was absent or markedly decreased in 58 of 59 complete hydatidiform moles. In all gestations p57KIP2 was strongly expressed in decidua and in intervillous trophoblast islands, which served as internal positive controls for p57KIP2 immunostaining. p57KIP2 immunohistochemistry can reliably identify most cases of complete hydatidiform mole irrespective of gestational age and is thus a useful diagnostic adjunct, complementary to ploidy analysis, in the diagnosis of hydatidiform mole.
Systems 3: multisensory access to the graphic based computers by persons who are blind (2003)

As personal computers have evolved, they have become an essential tool in the personal, educational, and professional lives of people who are blind. However, the advent of graphics-based operating systems (such as Macintosh, Windows and OS/2), has caused well-founded concern that computers will no longer be accessible to people who are blind, because these systems use a display technology incompatible with traditional screen access approaches. The Systems-3 prototype, through cooperative efforts and innovative programming, offers a solution to this screen access problem in one graphical environment, the Apple Macintosh and soon the Windows 3.0 environment as well. The prototype system not only allows access to what can be though of as traditionally textual information (standard word processing files, spreadsheets and databases) but also to information that is inherently graphical in nature (graphs, charts, diagrams, and line drawings). System 3 offers: keyboard access to menus, icons, windows etc; full page virtual tactile tablet, 2D sound, and other features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing (2019)

Dendritic cells (DCs) that drain the gut and skin are known to favor the establishment of T cell populations that home to the original site of DC-antigen (Ag) encounter by providing <i>soluble</i> "imprinting" signals to T cells in the lymph node (LN). To study the induction of lung T cell-trafficking, we used a protein-adjuvant murine intranasal and intramuscular immunization model to compare <i>in vivo</i>-activated Ag<sup>+</sup> DCs in the lung and muscle-draining LNs. Higher frequencies of Ag<sup>+</sup> CD11b<sup>+</sup> DCs were observed in lung-draining mediastinal LNs (MedLN) compared to muscle-draining inguinal LNs (ILN). Ag<sup>+</sup> CD11b<sup>+</sup> MedLN DCs were qualitatively superior at priming CD4<sup>+</sup> T cells, which then expressed CD49a and CXCR3, and preferentially trafficked into the lung parenchyma. CD11b<sup>+</sup> DCs from the MedLN expressed higher levels of surface podoplanin, Trem4, GL7, and the known co-stimulatory molecules CD80, CD86, and CD24. Blockade of specific MedLN DC molecules or the use of sorted DC and T cell co-cultures demonstrated that DC surface phenotype influences the ability to prime T cells that then home to the lung. Thus, the density of dLN Ag<sup>+</sup> DCs, and DC <i>surface</i> molecule signatures are factors that can influence the output and differentiation of lung-homing CD4<sup>+</sup> T cells.
Multiuse Al-MOF Chemosensors for Visual Detection and Removal of Mercury Ions in Water and Skin-Whitening Cosmetics (2020)

Water and cosmetics containing mercury can cause damage to the skin and body. There is a great need for in situ monitoring and removal of mercury ion concentrations with a highly selective, sensitive, accurate, rapid, and simple protocol in water and skin-whitening cosmetic products. In situ recognition is an easy and inexpensive approach for recognition and uptake of Hg2+ ions in skin-lightening cosmetics and water. Our system is based on the fabrication of a sticklike structure of the newly developed metal–organic framework (MOF) via a solvothermal protocol. The rodlike structure of the Al-MOF has a tremendously high surface area which is a powering point that supported it as a microporous substrate for loading a Hg2+ ion chromophore (bis(4-(dimethylamino)phenyl)methanethione). The thioketone derivative chromophore based on an Al-MOF microporous carrier allows visual monitoring of toxic mercury in a few seconds. The proposed chemosensors have a color change from yellow to a green color that is extremely noticeable by the naked eye. Our designated chemosensors sensitivity (0.8 ppb) toward mercury ions was found to be lower than the WHO permissible drinking water limits which made it a good choice for in situ pretests of drinking water. Moreover, superior adsorption characteristics of the fabricated thioketone Al-MOF (TAM) nanorods as adsorbent were achieved. A high adsorption capacity was observed (1110 mg/g) in solution for capturing of mercury ions. Our developed protocol is built on the use of a small amount of prepared optical chemosensors, about 20 mg, for all measurements and the potential for multiple uses after a simple regeneration process. Our results revealed that the designed TAM nanorods would be a promising means of visualizing mercury ions in water and cosmetics products.
Topographic- and Wavefront-guided Customized Ablations With the NIDEK-EC5000CXII in LASIK for Myopia (2006)

The data support that the treatment of myopia and myopic astigmatism is safe and effective with NAVEX. Customized ablation based on corneal topography rather than on total wavefront error was more predictable.
PNNI clustering under node mobility in ATM networks (2002)

This paper examines the issue of PNNI routing in the context of mobile ATM networks. For reasons of efficiency, the PNNI protocol has been invented in order to aggregate ATM switches into groups. In the context of PNNI, the formation of peer groups is an important issue. This paper presents an aggregation algorithm that produces an optimal node group arrangement by taking into consideration the physical constraints such as node distance, node affinity and maximum peer group size. Furthermore, the issue of node mobility and its impact on the peer group assignment are considered. As the position of nodes changes with time, the network hierarchy may no longer be optimal and, therefore, may need rearrangement. The focus of this paper is to develop the criteria used for deciding when to perform network rearrangements. A metric is introduced for assessing the relative difference between the current node assignment and the optimal one. The impact of the various parameters is investigated by both analytical and simulation means.
Optimal Admission and Eviction Control of Secondary Users at Cognitive Radio HotSpots (2009)

Cognitive radio (CR) HotSpot is a typical example of commercialized dynamic spectrum access (DSA) in which a wireless service provider (WSP) provides CR end-users access to its local-area network. A WSP temporarily leases licensed channels from the primary licensees via spectrum auction, and subleases them to CR end-users or customers, each demanding a different amount of spectrum, according to its own advertised pricing policy. The CR customers use the subleased channels opportunistically when the channels are not being used by primary/legacy users, and hence, the amount of available spectrum resource varies with time. A WSP should, therefore, maximize its average profit by 'optimally' (in some sense) (1) controlling the admission/rejection of arriving CR end-users, and (2) determining a policy of evicting in-service opportunistic users at the channel to which primary users return. To our best knowledge, this is the first attempt to jointly optimize admission and eviction controls for the dynamic spectrum market. The WSP's profit maximization problem is formulated with a semi-Markov decision process (SMDP) and its corresponding linear programming (LP) setup. This problem is found to become nonlinear programming (NLP) subject to two quality-of-service (QoS) constraints on request-blocking and user-dropping probabilities, which can fortunately be converted to LP via some manipulation. Using an extensive numerical analysis, we discovered that the derived optimal policy achieves up to 81% more profit than a complete-sharing (CS) algorithm in the tested scenario. We also investigate tradeoffs between the two QoS constraints, and consider other important factors affecting WSP's profit maximization such as the number of leased channels, the end-user pricing, and the cost for reimbursing evicted customers.
High‐Density Electron Anions in a Nanoporous Single Crystal: [Ca24Al28O64]4+(4e‐). (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Measurement of the Influence of the Microstructure of Alumina‐Supported Cobalt Catalysts on their Activity and Selectivity in Fischer–Tropsch Synthesis by using Steady‐State and Transient Kinetics (2017)

Abstract Five alumina‐supported Co catalysts with different particle sizes and structures were synthesized. The catalysts showed different activities during long‐term Fischer–Tropsch experiments. Steady‐state isotopic transient kinetic analysis (SSITKA) 12 CO/H 2 → 13 CO/H 2 experiments were performed during these long‐term runs. The number of active sites for CO adsorption and activation was estimated through the summation of all surface intermediates derived from the SSITKA results. Rather than comparing turnover frequencies, a kinetic analysis was performed. A simple kinetic rate equation based on the in situ number of active sites described the steady‐state CO conversion over the five catalysts adequately. Thus the difference in the catalytic performance could not be attributed to a difference in particle size, phase orientation (face‐centered cubic or hexagonal close packed), or Pt‐promotion effect but instead was only because of the number of reduced Co atoms exposed during the reaction. Similarly, the selectivity depended on the CO conversion level and temperature and not on the catalyst structure.
3,3′-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions (2015)

Oxidative stress in the retinal pigment epithelium (RPE) can lead to the pathological causes of age-related macular degeneration (AMD). Hypoxia induces oxidative damage in retinal pigment epithelial cells (RPE cells). In this study, we investigated the capacity of 3,3'-diindolylmethane (DIM) to reduce the expression of vascular endothelial growth factor (VEGF) under hypoxic conditions, as well as the molecular mechanisms involved. Human RPE cells (ARPE-19 cells) were treated with cobalt chloride (CoCl2, 200 µM) and/or DIM (10 and 20 µM). The production of VEGF was measured by enzyme-linked immunosorbent assay. The translocation of hypoxia-inducible factor-1α (HIF-1α) and nuclear factor-κB (NF-κB) was determined by western blot analysis. The binding activity of HIF-1α and NF-κB was analyzed by electrophoretic mobility shift assay. The phosphorylation levels of mitogen-activated protein kinases (MAPKs) were measured by western blot analysis. The levels of mitochondrial reactive oxygen species (ROS) were detected by fluorescence microplate assay. The results revealed that DIM significantly attenuated the CoCl2-induced expression of VEGF in the ARPE-19 cells. The CoCl2-induced translocation and activation of HIF-1α and NF-κB were also attenuated by treatment with DIM. In addition, DIM inhibited the CoCl2-induced activation of p38 MAPK in the ARPE-19 cells. Pre-treatment with YCG063, a mitochondrial ROS inhibitor, led to the downregulation of the CoCl2-induced production of VEGF by suppressing HIF-1α and NF-κB activity. Taken together, the findings of our study demonstrate that DIM inhibits the CoCl2-induced production of VEGF by suppressing mitochondrial ROS production, thus attenuating the activation of HIF-1α and p38 MAPK/NF-κB.
Effect of Urea on the Morphology of Co3O4 Nanostructures and Their Application for Potentiometric Glucose Biosensor (2014)

Abstract In this study, an effect of different concentrations of urea on the morphology of cobalt oxide (Co 3 O 4 ) nanostructures was investigated. The Co 3 O 4 nanostructures are fabricated on gold coated glass substrate by the hydrothermal method. The morphological and structural characterization was performed by scanning electron microscopy, and X‐ray diffraction techniques. The Co 3 O 4 nanostructures exhibit morphology of flowers‐like and have comprised on nanowires due to the increasing amount of urea. The nanostructures were highly dense on the substrate and possess a good crystalline quality. The Co 3 O 4 nanostructures were successfully used for the development of a sensitive glucose biosensor. The presented glucose biosensor detected a wide range of glucose concentrations from 1×10 −6 M to 1×10 −2 M with sensitivity of a −56.85 mV/decade and indicated a fast response time of less than 10 s. This performance could be attributed to the heterogeneous catalysis effect at glucose oxidase enzyme, nanoflowers, and nanowires interfaces, which have enhanced the electron transfer process on the electrode surface. Moreover, the reproducibility, repeatability, stability and selectivity were also investigated. All the obtained results indicate the potential use of the developed glucose sensor for monitoring of glucose concentrations at drugs, human serum and food industry related samples.
Abrupt and Arbitrary Profile Formation in Silicon Using a Low-Kinetic-Energy Ion Bombardment Process (1995)

We have discovered that the carrier concentration in an epitaxial silicon film formed by the low-energy ion bombardment process is easily controlled by changing the ion bombardment energy during the film growth. While maintaining the perfect crystallinity of an epitaxial silicon layer grown at a temperature as low as 350° C, an arbitrary-shaped carrier concentration profile has been created in the film. Formation of box-shaped profiles as well as staircase-shaped profiles having very abrupt transitions is demonstrated. Formation of such arbitrary-shaped carrier profiles in an epitaxial layer is quite essential in the design of ultrasmall-dimension devices. The stability of carrier profiles against heat treatments also has been investigated.
Synthesis and Magnetic Properties of Fe-incorporated Carbon Nanofibers by Ion-irradiation Method (2010)

The Fe-incorporated carbon nanofibers (Fe-CNFs) grew on the graphite plate surface irradiated by Ar+ ions with a simultaneous Fe supply. The average diameter and length of the Fe-CNFs were in the range of 10-50 nm and 0.5-3 μm, respectively. As confirmed by TEM observation, the Fe-CNFs thus grown were characterized by amorphous-like or very fine crystalline nature. Compared with bulk Fe, they possessed higher coercivities for both parallel and perpendicular directions to the substrate at room temperature. In addition, magnetic properties of the Fe-CNFs strongly depended on the Fe content: The higher the Fe content, the stronger the saturation magnetization, whereas perpendicular coercivity was obtained for lower Fe supply rates.
Performance analysis of multihop FSO systems using APD receivers over log-normal channels (2013)

This paper studies the performance of multihop free-space optical (FSO) communication systems using the binary phase-shift keying modulation (BPSK) and avalanche photodiode (APD) receivers over atmospheric turbulence channels. We consider both serial and parallel relaying configurations with the decode-and-forward (DF) mode. The outage probability is analytically derived taking into account the log-normal turbulence channel model and receiver noise for both relaying configurations. In our analysis, the optimum of APD gain for achieving lowest outage probability with different relaying configurations and receiver parameters is discussed. The analytical results are verified by Monte-Carlo simulation and a good agreement between the analytical and simulation results is confirmed.
Figure S1 from Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements (2023)

&lt;p&gt;Regulation of SNPH ubiquitination&lt;/p&gt;
Theoretical and Experimental Investigation of Efficient Photonic Crystal Cavity-Waveguide Couplers (2006)

Coupling of photonic crystal (PC) linear three-hole defect cavities to PC waveguides is theoretically and experimentally investigated. An improved coupling is obtained by tilting the cavity axis by 60deg with respect to the waveguide direction
A fully integrated SONET OC-48 transceiver in standard CMOS (2001)

This paper presents the first fully integrated, SONET OC-48 (2.488/2.666 Gb/s) transceiver using a standard CMOS process. Careful design methodology combined with a standard CMOS technology allows performance exceeding SONET requirements with the added benefits of reduced power dissipation, higher integration levels, and simplified manufacturability as compared to other fabrication technologies. This chip, designed using a standard 0.18-/spl mu/m CMOS technology, has a total power dissipation of 500 mW and an rms jitter of 1 ps.
Creep Recovery and Molecular Structure of Polyethylene Melts (1998)

This contribution deals with the correlation between the molecular structure of polyethylenes and their rheological properties in shear creep recovery experiments. This experimental mode has the advantage that the complete time dependence of the viscoelastic behaviour of polymer melts can be obtained without being masked by the viscous part of deformation.
ChemInform Abstract: Synthesis and Structural Characterization of the 28‐Isopolytungstate Fragment [H2W28O95]20‐ Stabilized by Two External Lanthanide Ions [Ln2(H2O)10W28O93 (OH)2]14‐. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fingertip detection based on protuberant saliency from depth image (2017)

We propose a new approach for detecting a protuberant region from a depth image by leveraging a notion of protuberant saliency which describes how much the protuberant region stands out from its surroundings in the depth image. An intuitive and simple method is designed to calculate protuberant saliency from depth image, which can be used effectively together with the nearness information to detect the tip of a protuberant object such as a fingertip. We evaluate and compare our method with several state-of-the-art saliency methods for fingertip detection. Experimental results demonstrate that our method outperforms the comparing methods in terms of detection accuracy, being more robust against the rotation and isometric deformation of a fingertip region, the scale and depth noise issues, and the low resolution of a depth image.