gebhart/patrepeval huggingface dataset:
Wideband protection filter: single filter for laser damage preventing at wide wavelength range (2007)

We present a passive, solid-state threshold-triggered Wideband Protection Filter (WPF) that blocks the transmission only if the power exceeds a certain threshold. We demonstrate the protection ability of the WPF against laser threats including protection behavior for single and series of pulses. The WPF can be readily used for protection of detectors, cameras, or eye safety.
Effects of Decreased Renal Cortical Expression of G Protein-Coupled Receptor Kinase 4 and Angiotensin Type 1 Receptors in Rats (2008)

Abnormalities in renal angiotensin type 1 receptor (AT1R), D1 dopamine receptor (D1R) and G protein-coupled receptor kinase 4 (GRK4) are present in polygenic hypertension. Selective renal reduction of AT1R expression by intrarenal cortical infusion of antisense oligodeoxynucleotides (As-Odns) in conscious, uninephrectomized, sodium-loaded rats decreases proteinuria, normalizes the glomerular sclerosis index (GSI), increases the sodium excretion (UNaV), and modestly increases blood pressure (BP) in spontaneously hypertensive rats (SHR) but not in normotensive Wistar-Kyoto rats (WKY). In contrast, selective renal reduction of GRK4 expression by infusion of GRK4 As-Odns increases UnaV, attenuates the increase in arterial BP with age, and modestly decreases protein excretion in SHR, but not in WKY. In this study, we report that intrarenal cortical infusion of both GRK4 and AT1R As-Odns decreased BP and increased UNaV in SHR; these effects were also noted in WKY to a lesser extent. Infusion of SHR with this combination of As-Odns resulted in a decrease in proteinuria and improvement of GSI similar to those by AT1R As-Odn only. In contrast to the increased circulating angiotensin II and aldosterone levels induced by AT1R As-Odn alone, the combination of As-Odns decreased both, contributing to greater natriuresis and amelioration of hypertension than by GRK4 or AT1R As-Odn only. Our results indicate an interaction between GRK4-regulated receptors and the renin-angiotensin system in the regulation of renal function and BP.
Isomerization‐Induced Asymmetric Coordination Chemistry: From Auxiliary Control to Asymmetric Catalysis (2010)

Ein Weg zur Asymmetrie: Das chirale (S)-2-(Isopropylsulfinyl)phenol und sein elektronenreicheres Methoxyderivat (R=OCH3) können die chiralitätserzeugende trans-cis-Isomerisierung zweier 2,2′-Bipyridin-Liganden in einem oktaedrisch koordinierten Rutheniumkomplex auslösen und sogar katalysieren. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. (1987)

Intrinsic and acquired multidrug resistance is an important problem in cancer therapy. Multidrug resistance results from overexpression of the MDR 1 gene, which encodes a drug-efflux pump called P-glycoprotein. We have isolated a 1-kilobase genomic fragment containing the major transcription initiation sites for the human MDR 1 gene. Ribonuclease protection experiments using this fragment indicate that normal human adrenal, colon, and liver cells, the human hepatoma cell line HepG2, and vinblastine-selected human KB multidrug-resistant cells initiate transcription of the MDR 1 gene at the same site within this fragment. The 0.43-kilobase region upstream from the major transcription initiation site linked to the chloramphenicol acetyltransferase gene showed promoter activity in CV-1 monkey kidney cells and in human KB cells. The putative promoter region has a consensus CAAT box and two GC box-like sequences, but no TATA sequence. This identification and isolation of promoter sequences for the MDR 1 gene will permit studies on how expression of this gene is regulated in normal human tissues and cancers.
Prospective evaluation of the coronary sinus anatomy in patients undergoing electrophysiologic study (1999)

Anomalies of the CS as diverticula, persistent superior vena cava, or enlargement of the CS ostium are predominantly found in patients with accessory pathway-related tachycardias. Diverticula of the proximal CS were found in 7% of patients with accessory pathways; in these cases, ablation succeeded mostly by radiofrequency (RF) current delivery in the neck of the diverticulum. Enlargement of the CS ostium was more often seen in patients with AVNRT than in all other patients. However, in general the measurements of the coronary sinus ostium did not significantly differ in patients with AVNRT compared with the control group.
Free‐breathing whole‐heart coronary MRA with 3D radial SSFP and self‐navigated image reconstruction (2005)

Respiratory motion is a major source of artifacts in cardiac magnetic resonance imaging (MRI). Free-breathing techniques with pencil-beam navigators efficiently suppress respiratory motion and minimize the need for patient cooperation. However, the correlation between the measured navigator position and the actual position of the heart may be adversely affected by hysteretic effects, navigator position, and temporal delays between the navigators and the image acquisition. In addition, irregular breathing patterns during navigator-gated scanning may result in low scan efficiency and prolonged scan time. The purpose of this study was to develop and implement a self-navigated, free-breathing, whole-heart 3D coronary MRI technique that would overcome these shortcomings and improve the ease-of-use of coronary MRI. A signal synchronous with respiration was extracted directly from the echoes acquired for imaging, and the motion information was used for retrospective, rigid-body, through-plane motion correction. The images obtained from the self-navigated reconstruction were compared with the results from conventional, prospective, pencil-beam navigator tracking. Image quality was improved in phantom studies using self-navigation, while equivalent results were obtained with both techniques in preliminary in vivo studies.
PRE-SAFE Impulse - Early Interacting Occupant Restraint System (2013)

The safety level in modern vehicles is extremely high. Restraint systems that are currently used, consisting of the seat belt and airbag system, feature a mature level of optimization. In the investigation examined here, the authors shall leave behind the classic restraint system approach and discuss the question as to whether and how occupant restraint could be initiated in a hazardous situation even before the seat belt and airbag system responds. Could the valuable milliseconds between the start of the crash and the response of the occupant restraint system be used for dissipating energy? The purpose of this investigation is to design a system for early occupant impact protection that reduces the forces to which occupants are subjected during a crash. The focus is on frontal collisions. By inputting energy in a targeted manner, occupants are already restrained at the point in ti me when vehicle deceleration has still had only minor or no effects on the occupants. Methods for inputting energy as well as implementing this are examined. Furthermore, the paper describes the differences in occupant kinematics caused by the system and highlights the potential this technology holds for reducing the forces to which occupants are subjected. Based on the results of the preliminary investigation, the predevelopment of an approach for implementing an early occupant impact protection system that is fit for production is described. At the end of the paper, the authors present this system, with all the advantages it holds, as well as an outlook with regard to the potentials still to be exploited.
Spectral Tuning in Nitride Phosphors By Compositional Tailoring (2013)

Abstract not Available.
Two Cases of Hypersexuality Probably Associated with Aripiprazole (2013)

Sexual dysfunction is a common side effect in patients treated with antipsychotics but significant differences exist across different compounds. We report hypersexuality symptoms in two female patients with schizophrenia who were receiving treatment with aripiprazole. The patients experienced more frequent sexual desire and greater sexual preoccupation after taking aripiprazole. We discuss the potential neuro-chemical mechanisms for this and argue that aripiprazole's unique pharmacological profile, partial agonism with high affinity at dopamine D2-receptor, may have contributed to the development of these symptoms.
Bioelectrical Impedance Analysis (BIA) to measure alterations on hydroelectrolytic equilibrium of peripheral cells in COVID-19 patients with nonthyroidal illness syndrome (NTIS) (2022)

In COVID-19 patients the occurrence of low T3 serum values is associated with disease severity and death, but hormonal substitutive replacement is still debated. Clinical trials reported so far failed to demonstrate clear beneficial effects of T3, T4 or both treatments. With the aim to analyze the peripheral effects of the acute deficiency of T3 in blood, we analyzed body fluid composition in 74 COVID-19 patients, admitted to our University Hospital during the last pandemic wave. COVID-19 patients were sub divided into those that presented low FT3 serum levels, i.e.,  1.7 pg/ml (n. 42), 13 of which showed very low FT3 serum values, i.e.,  1.1 pg/ml, and those that showed normal FT3 serum levels, i.e., &amp;gt; 1.7 pg/ml (n. 32). Body fluid composition was analyzed by Bioelectrical Impedance Analysis (BIA). &#13;\nWe demonstrated that COVID-19 patients with low FT3 serum values exhibited increased values of the Total Body Water/Free Fat Mass (TBW/FFM) ratio. Patients with the lowest FT3 serum values had also the highest level of TBW/FFM ratio, an indicator of the fraction of FFM as water and one of the best-known body-composition constants in mammals. We found an inverse correlation between FT3 serum values and this constant. Reduced FT3 serum values in COVID-19 patients were correlated with the increase in the total body water (TBW), the extracellular water (ECW) and the sodium/potassium exchangeable ratio (Nae:Ke), and with the reduction of the intracellular water (ICW). Since the Na+/K+ pump is a well-known T3 target, we measured the mRNA expression levels of the two genes coding for the two major isoforms of this pump. We demonstrated that COVID-19 patients with NTIS had lower levels of mRNA of both genes in the peripheral blood mononuclear cells (PBMC)s obtained from our patients during the acute phase of the disease. &#13;\nIn conclusion, we demonstrated that the acute T3 deficit in our COVID-19 patients has marked effects on the hydroelectrolytic equilibrium of their peripheral blood mononuclear cells. The Na+/K+ pump is a possible target of T3 action, involved in the pathogenesis of the anasarcatic condition observed in these patients. Measurement of BIA parameters is a useful method to analyze water and salt retention in COVID-19 patients hospitalized in ICU that develop NTIS and may represent a novel reliable outcome to evaluate the benefit of T3 treatment in future clinical interventional trials.
The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect (2017)

Many DNA lesions associated with lymphoid malignancies are linked to off-target cleavage by the RAG1/2 recombinase. However, off-target cleavage has mostly been analyzed in the context of DNA repair defects, confounding any mechanistic understanding of cleavage deregulation. We identified a conserved SQ phosphorylation site on RAG2 365 to 366 that is involved in feedback control of RAG cleavage. Mutation of serine 365 to a non-phosphorylatable alanine permits bi-allelic and bi-locus RAG-mediated breaks in the same cell, leading to reciprocal translocations. This phenomenon is analogous to the phenotype we described for ATM kinase inactivation. Here, we establish deregulated cleavage itself as a driver of chromosomal instability without the associated repair defect. Intriguingly, a RAG2-S365E phosphomimetic rescues the deregulated cleavage of ATM inactivation, reducing the incidence of reciprocal translocations. These data support a model in which feedback control of cleavage and maintenance of genome stability involves ATM-mediated phosphorylation of RAG2.
Statins and muscle pain (2020)

<b>Introduction</b>: Statins remain among the most frequently prescribed drugs and constitute a cornerstone in the prevention of cardiovascular disease. However, muscle symptoms are often reported from patients on statins. Muscle symptoms are frequently reported as adverse events associated with statin therapy.<b>Areas covered</b>: In the present narrative review, statin-associated muscle pain is discussed. It elucidates potential mechanisms and possible targets for management.<b>Expert opinion</b>: In general, the evidence in support of muscle pain caused by statins is in some cases equivocal and not particularly strong. Reported symptoms are difficult to quantify. Rarely is it possible to establish a causal link between statins and muscle pain. In randomized controlled trials, statins are well tolerated, and muscle-pain related side-effects is similar to placebo. There are also nocebo effects of statins. Exchange of statin may be beneficial although all statins have been associated with muscle pain. In some patients reduction of dose is worth trying, especially in primary prevention Although the benefits of statins outweigh potential risks in the vast majority of cases, careful clinical judgment may be necessary in certain cases to manage potential side effects on an individual basis.
Dynamic and Static Light Scattering Studies on Self-Aggregation Behavior of Biodegradable Amphiphilic Poly(ethylene oxide)−Poly[(R)-3-hydroxybutyrate]−Poly(ethylene oxide) Triblock Copolymers in Aqueous Solution (2006)

The self-aggregation behavior of two amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) (PEO-PHB-PEO) triblock copolymer samples with nearly identical PHB block lengths but different PEO block lengths, PEO-PHB-PEO(2000-810-2000) and PEO-PHB-PEO(5000-780-5000), was studied with dynamic and static light scattering (DLS and SLS), in combination with fluorescence spectroscopy and transmission electron microscopy (TEM). The formation of polymeric micelles by the two PEO-PHB-PEO triblock copolymers was confirmed with fluorescence technique and TEM. DLS analysis showed that the hydrodynamic radius (R(h)) of the monodistributed polymeric micelles increased with an increase in PEO block length. The relative thermostability of the triblock copolymer micelles was studied by SLS and DLS at different temperatures. The aggregation number and the ratio of the radius of gyration over hydrodynamic radius were found to be independent of temperature, probably due to the strong hydrophobicity of the PHB block. The combination of DLS and SLS studies indicated that the polymeric micelles were composed of a densely packed core of hydrophobic PHB blocks and a corona shell formed by hydrophilic PEO blocks. The aggregation numbers were found to be approximately 53 for PEO-PHB-PEO(2000-810-2000) micelles and approximately 37 for PEO-PHB-PEO(5000-780-5000) micelles. The morphology of PEO-PHB-PEO spherical micelles determined by DLS and SLS measurements was further confirmed by TEM.
A Miniature Microscope for Two-Photon Imaging and Femtosecond Laser Surgery (2007)

We present a miniaturized two-photon microscope system employing air-core photonic crystal fiber and a resonantly-driven two-axis MEMS scanning mirror for simultaneous cellular imaging and femtosecond laser microsurgery. We will present design analysis and performance characterization.
Nonlinear Enhancement of Weak Signals Using Optimization Theory (2006)

Stochastic resonance (SR) is a phenomenon that performance of the nonlinear system can be improved with the addition of optimal amount of noise. Stochastic resonance has been increasingly used for signal processing. The output of the nonlinear bistable dynamic system with white Gaussian noise input can be used to restore the weak input signal, if the similarity between the input signal and the output can be maximized. This paper first use the optimization theory to show that the normalized power norm describing the similarity will reach a larger maximum when tuning both system parameters and noise intensity, compared with that of only adjusting noise intensity (classical stochastic resonance) or only adjusting system parameters. Then, computer simulations are performed to verify this proposal and demonstrate its application in signal processing
Two-site study on performances of a commercially available MALDI-TOF MS-based assay for the detection of colistin resistance in Escherichia coli (2023)

Colistin is a last resort drug for the treatment of multiple drug-resistant (MDR) Gram-negative bacterial infections. Rapid methods to detect resistance are highly desirable. Here, we evaluated the performance of a commercially available MALDI-TOF MS-based assay for colistin resistance testing in Escherichia coli at two different sites. Ninety clinical E. coli isolates were provided by France and tested in Germany and UK using a MALDI-TOF MS-based colistin resistance assay. Lipid A molecules of the bacterial cell membrane were extracted using the MBT Lipid Xtract Kit™ (RUO; Bruker Daltonics, Germany). Spectra acquisition and evaluation were performed by the MBT HT LipidART Module of MBT Compass HT (RUO; Bruker Daltonics) on a MALDI Biotyper® sirius system (Bruker Daltonics) in negative ion mode. Phenotypic colistin resistance was determined by broth microdilution (MICRONAUT MIC-Strip Colistin, Bruker Daltonics) and used as a reference. Comparing the results of the MALDI-TOF MS-based colistin resistance assay with the data of the phenotypic reference method for the UK, sensitivity and specificity for the detection of colistin resistance were 97.1% (33/34) and 96.4% (53/55), respectively. Germany showed 97.1% (33/34) sensitivity and 100% (55/55) specificity for the detection of colistin resistance by MALDI-TOF MS. Applying the MBT Lipid Xtract™ Kit in combination with MALDI-TOF MS and dedicated software showed excellent performances for E. coli. Analytical and clinical validation studies must be performed to demonstrate the performance of the method as a diagnostic tool.
Guidelines based on life cycle assessment for solvent selection during the process design and evaluation of treatment alternatives (2014)

This work allows the gathering of information during the process design to assist in the choice of the solvent and technology to use.
Post hoc analyses of East Asian patients from the randomized placebo-controlled PREVAIL trial of enzalutamide in patients with chemotherapy-naïve, metastatic castration-resistant prostate cancer (2017)

NCT01212991.
Effect of the Chemical Modification of Dextran on the Degradation by Dextranase (1990)

Dextran was modified using three different methods: a) partial periodate oxidation and subsequent reduction of the aldehyde groups, b) suc cinoylation and c) chloroformate activation with subsequent reaction with 2- hydroxypropylamine, ethylenediamine and tris(2-aminoethyl)amine. Degrada tion of these dextran derivatives by dextranases was investigated. It was observed that the rate of degradation decreased with increasing degree of chemical modification of the parent polysaccharide. The nature of modification had no significant influence on the rate of degradation.
Supplementary Table 5 from BET Bromodomain Inhibition of <i>MYC</i>-Amplified Medulloblastoma (2023)

&lt;p&gt;PDF file - 79K, C2 Gene Sets down-regulated following treatment with JQ1.&lt;/p&gt;
Auction Revenue in the General Spiteful-Utility Model (2016)

It is well accepted that, in some auctions, a player's "true utility" may depend not only on the price he pays and whether or not he wins the good, but also on various forms of externalities, such as the prices paid by his competitors, and the identity and true value of the actual winner.
The O52 network by molecular design: CECD tetrablock terpolymers (2009)

Varying the length of poly(dimethylsiloxane) in poly(cyclohexylethylene-b-ethylene-b-cyclohexylethylene-b-dimethylsiloxane) (CECD) block terpolymers between 0 and 20% produces the sequence of ordered phases: cylindrical-to-network-to-cylindrical. Small-angle X-ray scattering and transmission electron microscopy demonstrate Pnna space group symmetry and a unique network morphology stabilized by the asymmetric molecular architecture and block interactions. These results establish a new design principle for the generation of triply periodic and multiply continuous nanostructured soft materials.
A Distributed Approach to Energy Efficiency in Seamless IoT Communications (2021)

The rapid growth of Internet-of-things (IoT) devices modernizes our society and lives. Such a growth leads to the pro-liferation of the wireless technologies, most of which occupy the unlicensed/open industrial, scientific and medical (ISM) bands. Since each of these wireless technologies adheres to different standards, they give rise to challenges like cross technology interference, incompatible security protocols and high energy consumption. In this work, we envision to achieve an energy-efficient communication on a seamless IoT platform. In specific, a game theoretical approach is proposed to formulate a multi-device IoT communication system. The existence and uniqueness of the Nash equilibrium is proven to achieve the optimal transmit power for the IoT devices. Moreover, a distributed scheme is developed for practical implementations depending on receiving signal strength indicators. Simulation results demonstrate that optimal transmit power can be achieved through the proposed scheme. We further implement and demonstrate the distributed approach on a universal software radio peripheral (USRP) testbed.
Active participation of CCR5+CD8+ T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease (1999)

We examined the molecular pathogenesis of graft-versus-host disease-associated (GVHD-associated) liver injury in mice, focusing on the role of chemokines. At the second week after cell transfer in the parent-into-F1 model of GVHD, CD8(+) T cells -- especially donor-derived CD8(+) T cells -- infiltrated the liver, causing both portal hepatitis and nonsuppurative destructive cholangitis (NSDC). These migrating cells expressed CCR5. Moreover, macrophage inflammatory protein-1alpha (MIP-1alpha), one of the ligands for CCR5, was selectively expressed on intralobular bile duct epithelial cells, endothelial cells, and infiltrating macrophages and lymphocytes. Administration of anti-CCR5 antibody dramatically reduced the infiltration of CCR5(+)CD8(+) T lymphocytes into the liver, and consequently protected against liver damage in GVHD. The levels of Fas ligand (FasL) mRNA expression in the liver were also decreased by anti-CCR5 antibody treatment. Anti-MIP-1alpha antibody treatment also reduced liver injury. These results suggest that MIP-1alpha-induced migration of CCR5-expressing CD8(+) T cells into the portal areas of the liver plays a significant role in causing liver injury in GVHD; thus, CCR5 and its ligand may be the novel target molecules of therapeutic intervention of hepatic GVHD.