gebhart/patrepeval huggingface dataset:
Deep Heating Using a Movable Applicator Phased Array Hyperthermia System: A preclinical feasibility study (1994)

A preclinical evaluation of the 'movable applicator phased array hyperthermia system' was performed. The system employs four coherent applicators enabling power steering by amplitude and phase control. This concept has already been used in other systems, but the combination with a compact applicator design and easy movement of applicators has not been used before. The paper contains a description of the system and a verification of its performance using quality assurance tests with scanned E-field measurements. A clinical simulation was performed in pig to address the clinical feasibility of the system. The target volume was the left kidney. Two heating sessions, with and without occluded blood-flow to the kidney, were performed. In the low-flow experiments a temperature of 48 degrees C and 46 degrees C was obtained in the upper and lower pole of the kidney respectively. For the high-flow experiment the temperature in the upper pole was 48 degrees C.
Rearrangements in the halogenation of tetraalkylethylenes with N-halosuccinimides and tert-butyl hypochlorite (1982)

The reaction of N-halosuccinimides and Me3COCl with tetraalkylethylenes involves halo-cation addn. to the double bond in a fast reaction, followed by abstraction of an allylic proton, resulting in a double bond shift. Homoallylic halogenation occurs in tetraalkylethylenes which can not undergo a double bond shift; e.g., adamantylideneadamantane gave the 4--halo deriv. The title electrophilic halogenation is compared with the well-known radical-chain allylic halogenation of mono-, di-, and trialkylethylenes with the same reagents and the reaction of chlorine with olefins. The halogenations of tetraalkylethylenes are strongly reminiscent of the singlet oxygen ene-reaction. [on SciFinder (R)]
Highly Efficient Synthesis of Alkyl N-Arylcarbamates from CO2, Anilines, and Branched Alcohols with a Catalyst System of CeO2 and 2-Cyanopyridine (2019)

Highly efficient synthesis of alkyl N-arylcarbamates from CO2, anilines, and alcohols using the CeO2 and 2-cyanopyridine catalyst system was substantiated by selecting branched alcohols, such as 2-propanol and cyclohexanol, with minimized formation of byproducts, such as dialkyl carbonates and picolinamide. The catalyst system is operable even at low CO2 pressure (≤1 MPa), and the target carbamates were obtained with high arylamine-based yields (up to 94%).
Data from A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity (2023)

&lt;div&gt;Abstract&lt;p&gt;SS1P is a recombinant immunotoxin (RIT) engineered for the targeted elimination of malignant cells that express the tumor-associated antigen mesothelin. It is composed of an antimesothelin antibody variable fragment (Fv) linked to a cytotoxic fragment of &lt;i&gt;Pseudomonas&lt;/i&gt; exotoxin A (PE) that includes domains II and III of native PE. The clinical use of SS1P is limited by its propensity to induce neutralizing antibodies and to cause a dose-limiting capillary leak syndrome (CLS) in patients. In this article, we describe a reengineered SS1P with improved properties that overcome these deficits. The redesign of SS1P consists of (i) removing the bulk of PE domain II (residues 251–273 and 284–394 of native PE), leaving only an 11-residue furin cleavage site, (ii) adding a Gly–Gly–Ser peptide linker after the furin cleavage site, and (iii) replacing eight highly solvent-exposed residues in the catalytic domain of PE. The new molecule, SS1-LR/GGS/8M, has cytotoxic activity comparable with SS1P on several mesothelin-expressing cell lines and remarkably improved activity on primary cells from patients with mesothelioma. In a mouse xenograft tumor model, high doses of SS1-LR/GGS/8M elicit antitumor activity superior to the activity of SS1P at its maximum-tolerated dose. In addition, SS1-LR/GGS/8M has greatly decreased ability to cause CLS in a rat model and reduced antigenicity or reactivity with antibodies to the sera of patients previously treated with SS1P. &lt;i&gt;Mol Cancer Ther; 12(1); 48–57. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Eddy Dissipation Rate (EDR) retrieval with ultra-fast high range resolution Electronic-Scanning X-band airport radar: Results of European FP7 UFO Toulouse Airport trials (2015)

At airports, runway operation is the limiting factor for the overall throughput; specifically the fixed and overly conservative ICAO wake turbulence separation minima. The wake turbulence hazardous flows can dissipate quicker because of decay due to air turbulence or be transported out of the way on oncoming traffic by cross-wind, yet wake turbulence separation minima do not take into account wind conditions. Indeed, for safety reasons, most airports assume a worst-case scenario and use conservative separations. However, with the aid of accurate EDR (Eddy Dissipation Rate) retrieval by Ultra-Fast High-Range Resolution X-band Electronic-Scanning radar sensors, more efficient intervals can be set, particularly when atmosphere is unstable and turbulent, accelerating Wake-Vortex decay. Depending on traffic volume, these adjustments can generate capacity gains, which have major commercial benefits. This paper presents Electronic scanning radar trials at Toulouse-Blagnac Airport for UFO (Ultra-Fast wind sensOrs for wake-vortex hazards mitigation) project, funded by European FP7 program, on Radar EDR retrieval & Calibration.
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells (2012)

The KRAS oncogene is found in up to 30% of all human tumors. In 2009, RNAi experiments revealed that lowering mRNA levels of a transcript encoding the serine/threonine kinase STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers. To test this hypothesis, we initiated a high-throughput screen using compounds in the Molecular Libraries Small Molecule Repository (MLSMR). Several hits were identified, and one of these, a quinoxalinone derivative, was optimized. Extensive SAR studies were performed and led to the chemical probe ML281 that showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors that were reported in the course of these studies. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. These results are consistent with other recent reports using small-molecule STK33 inhibitors. Small molecules having different chemical structures and kinase-selectivity profiles are needed to fully understand the role of STK33 in KRAS-dependent cancers. In this regard, ML281 is a valuable addition to small-molecule probes of STK33.
Controllable and stable organometallic redox mediators for lithium oxygen batteries (2019)

We introduce corrole-chelated metal complexes as stable redox mediators with adjustable redox potential in lithium–oxygen batteries.
2213 Improvement of Stability Using Estimated Alignment Torque for EPS (2005)

This paper proposes an advanced control strategy to improve steering maneuverability both on emergency steering and on slippery roads, with the Torque Controlled Active Steering, which means Electric Power Steering with advanced control method. This controller which is constructed based on self-aligning torque estimation and feedback compensation, aims to improve returnability by using the self-aligning torque estimator, that is applicable in various situations. We experiment with this control strategy and it confirms that our controller improves vehicle dynamics stability.
Hemostatic Effects of Stress Hormone Infusion (1994)

Infusion of stress hormones to concentrations found during surgery is safely tolerated and causes metabolic changes observed with surgery. Stress hormone infusion increases ex vivo platelet reactivity and fibrinogen concentrations that resemble changes seen postoperatively but does not recreate the postoperative decrease in fibrinolytic activity. Differences in neuroendocrine response between types of anesthesia may explain some postoperative changes in platelet function and acute phase reactivity, but additional uncharacterized factors are responsible for the differences in fibrinolysis.
Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function (2015)

Using vagus nerve stimulation (VNS), we sought to determine the contribution of vagal afferents to efferent control of cardiac function. In anesthetized dogs, the right and left cervical vagosympathetic trunks were stimulated in the intact state, following ipsilateral or contralateral vagus nerve transection (VNTx), and then following bilateral VNTx. Stimulations were performed at currents from 0.25 to 4.0 mA, frequencies from 2 to 30 Hz, and a 500-μs pulse width. Right or left VNS evoked significantly greater current- and frequency-dependent suppression of chronotropic, inotropic, and lusitropic function subsequent to sequential VNTx. Bradycardia threshold was defined as the current first required for a 5% decrease in heart rate. The threshold for the right vs. left vagus-induced bradycardia in the intact state (2.91 ± 0.18 and 3.47 ± 0.20 mA, respectively) decreased significantly with right VNTx (1.69 ± 0.17 mA for right and 3.04 ± 0.27 mA for left) and decreased further following bilateral VNTx (1.29 ± 0.16 mA for right and 1.74 ± 0.19 mA for left). Similar effects were observed following left VNTx. The thresholds for afferent-mediated effects on cardiac parameters were 0.62 ± 0.04 and 0.65 ± 0.06 mA with right and left VNS, respectively, and were reflected primarily as augmentation. Afferent-mediated tachycardias were maintained following β-blockade but were eliminated by VNTx. The increased effectiveness and decrease in bradycardia threshold with sequential VNTx suggest that 1) vagal afferents inhibit centrally mediated parasympathetic efferent outflow and 2) the ipsilateral and contralateral vagi exert a substantial buffering capacity. The intact threshold reflects the interaction between multiple levels of the cardiac neural hierarchy.
Surface and Interface Engineering and Observation of Quantum Transport in ZnO Based Heterojunctions (2008)

We have observed the quantum Hall-effect (QHE) of ZnO/MgxZn1−xO bilayers grown on ScAlMgO4 substrates by using pulsed-laser deposition. Two-dimensional electron gas was spontaneously formed in the interface due to the polarization mismatch between the layers. In order to obtain high electron mobility, we first developed a high-temperature annealed buffer layer, and then carefully investigated the growth temperature dependences of surface morphologies and electrical properties. As the result, electron mobility was recorded to be 440 cm2/Vs at room temperature and 5500 cm2/Vs at 1 K. The observation of QHE allows to access direct determination of the electronic structure of the heterointerface.
Cardiovascular Molecular MRI (2006)

Recent advances in contrast agent design and imaging techniques now make it possible to image some molecular targets at the cellular and subcellular level by MRI. In this review we highlight the use of super paramagnetic iron-oxide nanoparticles for molecular imaging applications in the cardiovascular system. The potential roles of these nanoparticles in cell labeling, targeted imaging and as activatable contrast agents are discussed.
Analysis of Carbohydrate–Carbohydrate Interactions Using Sugar-Functionalized Silicon Nanoparticles for Cell Imaging (2015)

Protein-carbohydrate binding depends on multivalent ligand display that is even more important for low affinity carbohydrate-carbohydrate interactions. Detection and analysis of these low affinity multivalent binding events are technically challenging. We describe the synthesis of dual-fluorescent sugar-capped silicon nanoparticles that proved to be an attractive tool for the analysis of low affinity interactions. These ultrasmall NPs with sizes of around 4 nm can be used for NMR quantification of coupled sugars. The silicon nanoparticles are employed to measure the interaction between the cancer-associated glycosphingolipids GM3 and Gg3 and the associated kD value by surface plasmon resonance experiments. Cell binding studies, to investigate the biological relevance of these carbohydrate-carbohydrate interactions, also benefit from these fluorescent sugar-capped nanoparticles.
Avis en réponse à la saisine de l’ANSM. Paris le 20 décembre 2019 (2019)

la diffusion de documents scientifiques de niveau recherche, publis ou non, manant des tablissements d'enseignement et de recherche franais ou trangers, des laboratoires publics ou privs.
Low‐complexity joint active and passive beamforming for RIS‐aided MIMO systems (2021)

Abstract In this paper, we consider the reconfigurable intelligent surface (RIS)‐aided MIMO systems to realize a high quality link between the base station (BS) and the users via a RIS. To achieve this goal, the active beamforming at the BS and the passive beamforming at the RIS should be jointly optimized. However, most of the existing joint optimization schemes that maximize the sum‐rate have high computational complexity due to the complex derivative calculations and matrix inversion. To this end, a biologically inspired particle swarm optimization (PSO) algorithm is exploited to solve the non‐convex sum‐rate optimization problem with low‐complexity. Simulation results show that the proposed scheme provides a better trade‐off between performance and complexity than existing solutions for RIS‐aided MIMO systems.
User-Centric Virtual Sectorization for Millimeter-Wave Massive MIMO Downlink (2017)

Considering the joint design of analog beamformers when both link ends of a millimeter (mm)-wave massive multiple input multiple-output (MIMO) system are equipped with hybrid digital/analog (HDA) structures, we aim to maximize the multi-user (MU) MIMO net average throughput of the downlink in a Frequency Division Duplex (FDD) system. To achieve this, we develop an optimization framework, namely user-centric virtual sectorization (UCVS), which explores the tradeoff of training overhead, beamforming gain, and spatial multiplexing gain. In the UCVS, both the channel-statistics based analog beamforming design and a non-orthogonal downlink training scheme are investigated to reduce the necessary cost of instantaneous channel acquisition. By maximizing an approximate net average throughput, we devise efficient algorithms to realize the suboptimal UCVS. With generic mm-wave channel models, we demonstrate by simulations that our proposed scheme outperforms state-of the-art methods in various scenarios typical for mm-wave communications.
Enzymic conversion of .alpha.-keto aldehydes to optically active .alpha.-hydroxy acids using glyoxalase I and II (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic conversion of .alpha.-keto aldehydes to optically active .alpha.-hydroxy acids using glyoxalase I and IIMark A. K. Patterson, Richard P. Szajewski, and George M. WhitesidesCite this: J. Org. Chem. 1981, 46, 23, 4682–4685Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/jo00336a011https://doi.org/10.1021/jo00336a011research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Decoupling light absorption and charge transport properties in near IR-sensitized Fe2O3 regenerative cells (2013)

We report a regenerative iron oxide nanorod solar cell sensitized with squarine (SQ02) dye, which improves the overall light harvesting due to the dye's complementary absorption. The use of illumination sources which enabled selective excitation of Fe2O3 and the dye independently allowed the decoupling of transport and light absorption in Fe2O3. From absorbed photon-to-current conversion efficiency (APCE) calculations, it was found out that about 80% (at λ = 680 nm) of the absorbed photons in SQ02 dye are converted to electrons and transported without any further loss into the FTO electrode. Impedance spectroscopy revealed that bulk recombination is still a prominent problem while utilizing hematite as a photoanode in a dye sensitized configuration.
The Multiple Myeloma Genomics Portal (2008)

Abstract Current integrative genomics projects are enabling new discoveries in cancer research through the ability to combine multiple modalities of data, e.g. gene expression, copy number, RNAi, exon resequencing, and epigenetics. However, the tools to access and analyze this data have traditionally been out of the reach of clinicians and research biologists, due to the widely distributed nature of the available data and the significant learning curve required to use the analytical tools. This problem is particularly relevant to the multiple myeloma research community because of the heterogeneity of genomic aberrations underlying this disease and lack of a central repository of multi-modal multiple myeloma data. To address these problems, the Broad Institute has created a pilot Multiple Myeloma Genomics Portal, http://www.broad.mit.edu/mmgp, which serves as an interface between biologists (and clinical investigators), analytical tools, and multiple myeloma datasets. The Portal provides access to a number of advanced gene expression, gene set enrichment, and copy number analyses and visualizations within an easy to use Web interface. These analyses can be performed on the datasets hosted on the Portal, which include previously published curated, high quality genomic multiple myeloma datasets as well as a new reference collection of multiple myeloma samples. The Portal is continuously updated with new datasets, data types, and analytical capabilities as they become available. The Portal’s accessibility allows it to serve as a significant venue for investigators from other fields, engaging a broader range of investigators in exploring these data, and its design is readily adaptable to integrative genomics studies of other cancer types.
ChemInform Abstract: THE (BIS‐2,6‐(1‐(2‐IMIDAZOL‐4‐YLETHYLIMINO)ETHYL)PYRIDINE)COPPER(I) CATION. A SYNTHETIC COPPER(I) OXYGEN CARRIER IN SOLUTION AS A POTENTIAL MODEL FOR OXYHEMOCYANIN (1981)

Abstract Die Schiffsche Basen‐Kondensation des Diacetylpyridins (I) mit Histamin bzw. 2‐(2‐Aminoethyl)pyridin (II) liefert die Liganden (III), die mit Cu(I)‐Komplexen bzw. Cu(ClO 4 ) 2 zu den Komplexen (IV) bzw. (V) führen.
Scalable algorithms for joint beam and null-forming using distributed antenna arrays (2014)

We consider the problem of multicasting a common message signal to a set of designated receivers from a distributed antenna array, while simultaneously forming nulls to another set of null targets. We propose an algorithm under which each transmitter in the distributed array iteratively makes an incremental adjustment to its complex gain (which controls the amplitude and phase of its transmitted RF signal). The cumulative effect of these incremental adjustments is that the individual transmitted RF signals from the transmitters add up at the intended receivers to a desired SNR level, while simultaneously canceling each other perfectly at the null targets. A crucial feature of this algorithm is that it can be implemented in a purely distributed fashion at each transmitter using only an estimate of its own channel gain to each receiver, and an aggregate feedback signal from each of the receivers that is broadcast to all the transmitters. This is an important advantage of our approach and assures its scalability; in contrast any non-iterative approach to the beam/nullforming problem requires knowledge of all channel gains - from all transmitters to all receivers - to be available at every transmitter.
In utero Partial Liver Resection in the Rabbit Model: A Study on Fetal Tissue Regeneration (1997)

In this study we developed a model of in vivo intrauterine partial liver resection in the fetal rabbit to analyze fetal liver regeneration. After intravenous anesthesia, 12 time-dated pregnant, California rabbits underwent a midline laparotomy and minimal hysterotomy at 24-25 days of gestational age. One fetus was exposed from each pregnant doe and the fetal liver was partially resected. Cesarean sections were performed 24, 48 and 72 h and 4 days after surgery. Three fetuses operated at 24 days of gestational age and 3 fetuses operated at 25 days were alive at retrieval. The fetuses and the sampled livers were weighed at retrieval and fetal liver weight showed a well-maintained value in all cases. Fetal livers were processed for the common histologic stains. Lymphocytes, polymorphonuclear leukocytes and phagocytes were counted from sections obtained in areas close to the edge of resection. Inflammatory cells showed a peculiar pattern of infiltration at different stages of repair, with a constantly increased number of phagocytes peaking 48 h after resection. Fetal liver seems to present a specific pattern of repair that differs from both the adult liver and other fetal tissues healing after injury.
Multi-modal weight control intervention for people with persistent mental disorders. (2008)

Obesity, a major problem worldwide, is more prevalent among people with schizophrenia. This study examined the effect of behavior intervention, nutritional information and physical exercise on the body mass index (BMI) and weight of people who were hospitalized with persistent DSM-IV schizophrenia and schizoaffective disorders. Fifty nine inpatients with a BMI greater than 25 participated, (28 intervention group; 31 control group). Significant reductions in BMI and weight were observed in the intervention group after 3 months and were maintained 1-year post study [F(1,52) = 6.1, p = .017) and F(1,52) = 3.7, P = .006, respectively]. If provided with adequate information and an appropriate framework, people with persistent schizophrenia can significantly reduce BMI and weight and maintain the loss.
Video Action Recognition Using Residual Vector Quantization and Hidden Markov Models. (2010)

In this paper, we discuss usage of a multi-stage Residual Vector Quantization (RVQ) strategy for human action recognition. To the best of our knowledge, this is the first reported application of multi-stage RVQ to any form of video processing. The RVQ is used to generate a single byte descriptor per image. The evolution of these descriptors is analyzed using a bank of HMM models, one per action to be classified. Correct classification is implemented by maximizing the posterior class conditional density. We report comparable classification results to state of the art methods, i.e. above 90%, while using less than half the available training set.