gebhart/patrepeval huggingface dataset:
Effect of ATM networks on the leaky bucket based characterization of IS-IP guaranteed service flows in an IP-ATM internetwork (2002)

This paper addresses the problem of determining the change in the leaky bucket (LB) based characterization of a guaranteed service flow as it traverses an ATM subnet in an IP-ATM internetwork. The LB-characterization of the flow changes at the ATM network boundaries since overhead is added/removed and delay is introduced due to the mapping between IP packets and ATM cells. We obtained analytical results on the change in the LB-characterization by analysing the effect of the ingress AAL5, egress AAL5, and ATM schedulers on the guaranteed service traffic. We verified our analytical results by simulation, using OPNET. Our main contribution is the determination of how the leaky bucket based characterization of a guaranteed service flow changes as it traverses an ATM subnet. These results are very important for resource allocation within the ATM subnet to support end-to-end guaranteed service sessions.
Infrared Optical Microfluidics for Simple Bioassays (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. T. Kotz, Y. Gu, and G. Faris, "Infrared Optical Microfluidics for Simple Bioassays," in Biomedical Optics, Technical Digest (CD) (Optica Publishing Group, 2006), paper TuI61. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Microvillous cells expressing IP3 receptor type 3 in the olfactory epithelium of mice (2010)

Microvillous cells of the main olfactory epithelium have been described variously as primary olfactory neurons, secondary chemosensory cells or non-sensory cells. Here we generated an IP3R3(tm1(tauGFP)) mouse in which the coding region for a fusion protein of tau and green fluorescent protein replaces the first exon of the Itpr3 gene. We provide immunohistochemical and functional characterization of the cells expressing IP3 receptor type 3 in the olfactory epithelium. These cells bear microvilli at their apex, and we therefore termed them IP3R3 MV cells. The cell body of these IP3R3 MV cells lies in the upper third of the main olfactory epithelium; a long thick basal process projects towards the base of the epithelium without penetrating the basal lamina. Retrograde labeling and unilateral bulbectomy corroborated that these IP3R3 MV cells do not extend axons to the olfactory bulb and therefore are not olfactory sensory neurons. The immunohistochemical features of IP3R3 MV cells varied, suggesting either developmental stages or the existence of subsets of these cells. Thus, for example, subsets of the IP3R3 MV cells make contact with substance P fibers or express the purinergic receptor P2X3. In addition, in recordings of intracellular calcium, these cells respond to ATP and substance P as well as to a variety of odors. The characterization of IP3R3 MV cells as non-neuronal chemoresponsive cells helps to explain the differing descriptions of microvillous cells in the literature.
Corticotropin-Releasing Factor (CRF) Family of Ligands and Their Receptors (1997)

Corticotropin-releasing factor (CRF) was recognized biologically in the 1950s and was first isolated from ovine hypothalamus and characterized as a 41 amino acid peptide in 1981. Subsequently, rat and human CRF were identified and found to be identical to one another, while differing from ovine CRF by seven residues. A variety of experimental observations indicate that CRF is the key neuroregulator of the hypothalamic-pituitary-adrenal cortical (HPA) axis. The actions of CRF on adrenocorticotropic hormone (ACTH) secretion are potentiated by vasopressin and blunted by glucocorticoid negative feedback. The broad central and peripheral distribution of the peptide and its receptors supports the notion that CRF is an important local regulator within the central nervous, immune, and other systems. Further, CRF mediates numerous complementary stress-related endocrine, immune, autonomic, and behavioral responses. Antagonists of CRF, such as α-helical CRF or astressin, block many stress-induced physiologic and pathophysiologic responses in experimental animals, and perturbations of the CRF system or the HPA have been reported in human affective disorders. The effects of CRF within the central nervous system may be anatomically and temporally limited by a high-affinity binding protein (CRF-BP). The actions of CRF are mediated by seven transmembrane-domain G-protein-coupled receptors (CRF-R) derived from two genes (R1 and R2), each of which has alternative splice variants. We have identified a novel urotensin and CRF-like peptide, urocortin, in the rat brain and the human genome. Urocortin has a high affinity for CRF-R1 and R2 as well as for CRF-BP. Synthetic urocortin has potent biological actions on both CRF-R1 (pituitary ACTH release) as well as CRF-R2 (vasodilation, reduction of vascular permeability) mediated events. This novel peptide appears to be an endogenous ligand for CRF-type 2 receptors.
Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS (2023)

These UPLC-MS/MS methods enable the rapid and sensitive quantification of lurbinectedin and its main metabolites in clinical samples.
ChemInform Abstract: The Palladium‐Catalyzed Trifluoromethylaiton of Vinyl Sulfonates. (2012)

Abstract The process can be carried out with either triflates or nonaflates and silanes (II) or (V) in combination with tBu‐XPhos and a Pd source.
ChemInform Abstract: Synthesis of Functionalized Maoecrystal V Core Structures. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Near-Field Optical Flying Head with Protruding Aperture and Its Fabrication (2005)

One of the most important parameters related to the near-field readout principle is aperture-to-media spacing (effective spacing). We proposed a near-field optical head with a protruding aperture that can reduce the effective spacing beyond the mechanical limit of the flying height and localize the near-field on the medium. Using nanostep lithography, we fabricated the protruding aperture, whose extension is 20 nm with 5 nm accuracy, so that the effective spacing is successfully reduced to 50 nm on a 3.2×3.6 mm flying head. We demonstrated signal readout with a 150 nm-long line-and-space pattern in chromium with the head. The flying height was estimated to be 75 nm, so that the effective spacing was 54 nm. The circumferential speed was 2.7 m/s and the signal frequency was 9.1 MHz. We also propose a promising structure for an optical head of higher density.
Supplementary File 4_Reactome Pathway Analysis from Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Enriched pathways derived from Reactome Pathway Analysis.&lt;/p&gt;
F-actin is involved in the polyethylene glycol-induced fusion of chick embryo fibroblasts. (1989)

Cytochalasin B inhibits the polyethylene glycol (PEG)-induced fusion of chick embryo fibroblasts. Induction of fusion of these cells by PEG is associated with transient changes in the pattern of F-actin organization within the cell. The changes include the disappearance of stress fibres and accumulation of F-actin under the plasma membrane. These results suggest an involvement of F-actin in PEG-induced cell fusion.
Graft Subsidence and Revision Rates Following Anterior Cervical Corpectomy (2017)

Study Design: Retrospective cohort study. Objective: To assess the subsidence and revision rates associated with different interbody cages following anterior cervical corpectomy and reconstruction. Summary of Background Data: Different interbody cages are currently used for surgical reconstruction of the anterior and middle columns of the spine following anterior cervical corpectomy. However, subsidence and delayed union/nonunion associated with allograft and cage reconstruction are common complications, which may require revision with instrumentation. Materials and Methods: We reviewed the cases of 75 patients who underwent cervical corpectomy and compared the radiographic graft subsidence and revision rates for fibula allograft, titanium mesh cage, titanium expandable cage, and carbon fiber cages. Subsidence was calculated by comparing the immediate postoperative lateral x-ray films to those obtained during follow-up visits. Results: The average graft subsidence was 3 mm and revision rate was 25% for fibula allograft versus 2.9 mm and 11.1%, 2.9 mm and 18.8% for titanium mesh cages and titanium expandable cages, respectively. The average graft subsidence for carbon fiber cages was 0.7 mm with no revision surgery in this subset. Conclusions: Our findings suggest that subsidence and revision rates following anterior corpectomy and interbody fusion could be minimized with the use of a carbon fiber cage.
Can tumor location on pre-treatment MRI predict likelihood of\n pseudo-progression versus tumor recurrence in Glioblastoma? A feasibility\n study (2020)

A significant challenge in Glioblastoma (GBM) management is identifying\npseudo-progression (PsP), a benign radiation-induced effect, from tumor\nrecurrence, on routine imaging following conventional treatment. Previous\nstudies have linked tumor lobar presence and laterality to GBM outcomes,\nsuggesting that disease etiology and progression in GBM may be impacted by\ntumor location. Hence, in this feasibility study, we seek to investigate the\nfollowing question: Can tumor location on treatment-na\\"ive MRI provide early\ncues regarding likelihood of a patient developing pseudo-progression versus\ntumor recurrence? In this study, 74 pre-treatment Glioblastoma MRI scans with\nPsP (33) and tumor recurrence (41) were analyzed. First, enhancing lesion on\nGd-T1w MRI and peri-lesional hyperintensities on T2w/FLAIR were segmented by\nexperts and then registered to a brain atlas. Using patients from the two\nphenotypes, we construct two atlases by quantifying frequency of occurrence of\nenhancing lesion and peri-lesion hyperintensities, by averaging voxel\nintensities across the population. Analysis of differential involvement was\nthen performed to compute voxel-wise significant differences (p-value&lt;0.05)\nacross the atlases. Statistically significant clusters were finally mapped to a\nstructural atlas to provide anatomic localization of their location. Our\nresults demonstrate that patients with tumor recurrence showed prominence of\ntheir initial tumor in the parietal lobe, while patients with PsP showed a\nmulti-focal distribution of the initial tumor in the frontal and temporal\nlobes, insula, and putamen. These preliminary results suggest that\nlateralization of pre-treatment lesions towards certain anatomical areas of the\nbrain may allow to provide early cues regarding assessing likelihood of\noccurrence of pseudo-progression from tumor recurrence on MRI scans.\n
Cell lineage analysis of the avian neural crest (1991)

Neural crest cells migrate extensively and give rise to diverse cell types, including cells of the sensory and autonomic nervous systems. A major unanswered question concerning the neural crest is when and how the neural crest cells become determined to adopt a particular fate. We have explored the developmental potential of trunk neural crest cells in avian embryos by microinjecting a vital dye, lysinated rhodamine dextran (LRD), into individual cells within the dorsal neural tube. We find that premigratory and emigrating neural crest cells give rise to descendants with distinct phenotypes in multiple neural crest derivatives. These results are consistent with the idea that neural crest cells are multipotent prior to their emigration from the neural tube and become restricted in phenotype after emigration from the neural tube either during their migration or at their sites of localization. To determine whether neural crest cells become restricted during their migration, we have microinjected individual trunk neural crest cells with dye shortly after they leave the neural tube or as they migrate through the somite. We find that a majority of the clones derived from migrating neural crest cells appear to be multipotent; individual migrating neural crest cells gave rise to both sensory and sympathetic neurons, as well as cells with the morphological characteristics of Schwann cells, and other non-neuronal cells. Even those clones contributing to only one neural crest derivative often contained both neurofilament-positive and neurofilament-negative cells. These data demonstrate that migrating trunk neural crest cells, like their premigratory progenitors, can be multipotent.(ABSTRACT TRUNCATED AT 250 WORDS)
Exploring design space of parallel realizations (2001)

Many applications lend them to parallelism at different levels of granularity. We first identify the key issues involved in creating a parallel model of an application. These are done with a view to estimate performance and explore the “parallel” design space to select a suitable design point. The framework presented provides an opportunity to perform this exploration both in the target architecture independent and target architecture dependent manner. An MPEG-2 decoder model in YAPI has been presented which has more parallelism and improved performance. This modal has further been mapped onto SpaceCAKE architecture to study its architectural parameters. Detailed results obtained with YAPI simulation (target architecture independent) and TSS simulation (after process-processor binding) on MPEG-2 decoder application establish the effectiveness of our approach.
Display of Stressed Liquid Crystal Light Tunable Glass (2012)

The properties of polymer dispersed liquid crystal(PDLC) and stressed liquid crystal(SLC) are introduced;the construction,principle and preparation process of stressed liquid crystal tunable glass are introduced.The SLC tunable display glass is prepared under the process of expose with writing pattern,the area covered becomes transmissible and the other side is changed into scattering.It looks like a frosted glass in scattering state with pattern display without stress applied,and it can be changed into translucent state and the pattern disappeared at the same time after sheared applied.As a kind of other display mode,the novel function SLC light tunable glass can be applied in the products of moveable windows or doors without power consuming,there will be the application prospect in the fields of construct fit up engineering for the user of company,market,hotel and so on.
Predictors of Neurological Motor Decline in Complex Adult Spinal Deformity Surgery: Results of the Prospective, International, Multicenter Scoli-RISK-1 Study (2016)

Introduction Significant variability in neurologic outcomes following surgical correction for ASD has been reported. Risk factors for decline in neurologic motor outcomes are poorly understood. The objective of this prospective, multicenter, international cohort study in 15 sites is to evaluate the incidence and risk factors for postoperative neurological motor decline in patients undergoing surgery for complex adult spinal deformity (ASD). Material and Methods From September 2011 to October 2012, 273 consecutive patients were prospectively enrolled. One patient lacked baseline ASIA lower extremity motor score (LEMS), and one patient did not have follow-up LEMS leaving 271 (99.27%) subjects for analysis. Decline in neurologic motor outcomes was defined as deterioration in any of discharge or 6 weeks American Spinal Injury Association (ASIA) Lower Extremity Motor Scores (LEMS) compared with pre-operative status. To identify risk factors associated with decline in LEMS, two step statistical analysis was performed. First, 128 candidate variables consisting of demographics, comorbidities, treatment history, disease severity, radiologic parameters and surgical details were screened in bi-variate models. Then, 53 variables that had a p-value of 0.2 or less were included in a multivariate logistic stepwise model. Results 70 (25.93%) patients showed decline and 200 (74.07%) had no decline in LEMS. Of those with a decline, nine patients (overall rate of 3.33%) had a severe deterioration of &gt; 10 points on LEMS scale. Key factors associated with postoperative neurological deterioration included older age, non East Asian ethnicity, cardiovascular disease, preoperative motor weakness, kyphosis on T12 – S1, focal severe deformity angle, pedicle subtraction osteotomy, thoracic level fusion and intraoperative motor evoked potential change. Conclusion Although complex ASD surgery can enhance the quality of life of adult patients with severe deformity, a significant portion of patients with ASD experience a postoperative decline in LEMS. The risk factors identified in this study are useful to help clinicians to anticipate and potentially develop strategies to reduce the risk of postoperative neurologic complications.
A General Cartographic Labelling Algorithm (1996)

Some apparently powerful algorithms for automatic label placement on maps use heuristics that capture considerable cartographic expertise but are hampered by provably inefficient methods of search and optimization. On the other hand, no approach to label placement that is based on an efficient optimization technique has been applied to the production of general cartographic maps—those with labelled point, line, and area features—and shown to generate labellings of acceptable quality. We present an algorithm for label placement that achieves the twin goals of practical efficiency and high labelling quality by combining simple cartographic heuristics with effective stochastic optimization techniques.
Ultra-low phase noise ADPLL for millimeter wave (2020)

Millimeter-wave (mm-wave) frequency synthesizers in complementary metal oxide-semiconductor (CMOS) suffer from poor phase noise (PN), limited tuning range (TR) and high-power consumption. They are the key subsystems that typically limit the performance of mm-wave transceivers. This chapter presents a new architecture for mm-wave frequency synthesis that improves its PN performance and power efficiency. Various different techniques are introduced and demonstrated in a 60-GHz fractional-N all-digital phase-locked loop (ADPLL).
Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-alpha. (1998)

TNF-alpha is implicated in the initiation of cytokine cascades in various inflammatory settings. To assess the interactions of multiple cytokines at the level of inflammatory effector cells, we examined the effects of TNF-alpha on the expression of two IL-8Rs (CXCR1 and CXCR2) on polymorphonuclear leukocytes (PMNs). TNF-alpha decreased the surface expression of CXCR2 in a dose- and time-dependent manner. In contrast, CXCR1 expression was not affected by TNF-alpha. The release of CXCR2 into the supernatant of TNF-alpha-treated PMNs was detected by immunoblotting and immuno-slot-blot analyses, suggesting that the down-regulation of CXCR2 was caused mainly by shedding from the cell surface. The CXCR2 down-regulation was inhibited by PMSF and aprotinin, supporting the hypothesis that the shedding was mediated by serine protease(s). The intracellular Ca2+ mobilization and chemotaxis in response to IL-8 were suppressed by the pretreatment of PMNs with TNF-alpha, indicating that the decrease in CXCR2 was reflected in the decreased functional responses to IL-8. In contrast, the O2- release, which is mediated by CXCR1, was not suppressed by TNF-alpha. The treatment of whole blood with TNF-alpha also caused a significant reduction in CXCR2 and markedly suppressed intracellular Ca2+ mobilization and chemotaxis in response to IL-8, while enhancing the O2- release. These findings suggest that TNF-alpha down-regulates CXCR2 expression on PMNs and modulates IL-8-induced biologic responses, leading to the intravascular retention of PMNs with an enhanced production of reactive oxygen metabolites.
Cover Feature: Potassium‐Ion Storage in Cellulose‐Derived Hard Carbon: The Role of Functional Groups (Batteries & Supercaps 9/2020) (2020)

The Cover Feature shows the potential utilization of carbon pyrolyzed from the most sustainable natural raw material for rechargeable batteries based on potassium-ion storage mechanism. More information can be found in theArticle by A. K. Nanjundan co-workers.
Conjugated Oligoelectrolytes: A Chain‐Elongated Oligophenylenevinylene Electrolyte Increases Microbial Membrane Stability (Adv. Mater. 18/2019) (2019)

Achieving biotechnological strain improvement using synthetic materials represents a simple approach compared to genetic techniques. In article 1808021, Jamie Hinks, Guillermo C. Bazan, and co-workers demonstrate a novel membrane-intercalating phenylenevinylene oligoelectrolyte, S6. S6 treatment of Escherichia coli improves butanol tolerance two-fold. Biophysical experiments deploying giant unilamellar vesicles show that S6 counters membrane instability caused by butanol exposure.
Supplemental Tables from CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies (2023)

&lt;p&gt;Supplemental Table 1. Overview of CD20-targeting T-cell bispecific molecules evaluated in the current study. Supplemental Table 2. Tumor cell lines and EC50 values of tumor cell lysis. Supplemental Table 3. Assessment of the activity in ex vivo primary tumor samples derived from aggressive lymphoma and leukemia patients. Supplemental Table 4. Absolute values of cytokines measured by multiplex analysis of blood samples reported as heatmap in Figure 3e, 4b, 5d, and 6b. Supplemental Table 5. Average score of perivascular CD3 positive T-cells in the lung (assessed by blinded pathologist analysis) referring to T-cell staining of lungs from tumor-bearing, HSC NSG mice 7 days after the first treatment and 24 h after the second treatment (treatment groups are indicated on Figure 6D panels).&lt;/p&gt;
Fabrication ofoptical waveguides inphosphorus-doped flame hydrolysis silica bydirect electron-beam exposure. (2005)

Therefractive index profiles ofoptical waveguides fabricated byelectron-beam irradiation of phosphorus doped flame-hydrolysis deposited silica werestudied bymicroreflectivit y. Theresults werecompared with those obtained forgermanium-doped silica. ©2004Optical Society ofAmerica