gebhart/patrepeval huggingface dataset:
Free-hand ultrasound scanning approaches for volume quantification of the mouse heart left ventricle (2007)

Two approaches for free-hand motion tracking that enable volumetric quantification of the murine heart were investigated. One approach used an instrumented, multijointed articulated arm attached to a 14 MHz ultrasound transducer array. A second approach used an E-beam transducer--a modified linear transducer array containing a main imaging array adjacent to three perpendicular tracking arrays. Motion between successive B-mode image frames was computed by tracking image speckle in each tracking array. Both tracking systems produced accurate results in a phantom validation study (4.50% error and 3.75% error for estimates derived using the articulated arm and E-beam tracking techniques, respectively). The tracking approaches also were tested in vivo on three mice. Results were compared to values obtained by mounting each mouse on a micromanipulator, adjusting its position by 0.5-mm increments, and acquiring B-mode images using a high-resolution ultrasound scanner. Left ventricular end diastolic volume (LVEDV) estimates differed from values obtained using the high-resolution scanner by a mean error of 18.2% and 2.60% for eight scans conducted on each of two mice using the articulated arm, and a mean error of 13.6%, 6.53%, and 12.58% for eight scans conducted on each of three mice using the E-beam.
20 W single-mode Yb^3+-doped phosphate fiber laser (2006)

We report the demonstration of the first, to our knowledge, cladding-pumped continuous-wave Yb(3+)-doped phosphate-glass fiber laser. Phosphate hosts are of interest because they can be much more heavily doped than silica, and because of the possibility that they may have a higher photodarkening threshold. In an 84.6 cm double-clad fiber doped with 12 wt. % of Yb(2)O(3) and laser-diode pumped at 940 nm, nearly 20 W of single-mode 1.07 microm output power was generated with 60.2 W of absorbed pump power. The measured dependence of the output power on pump power is in excellent agreement with simulations.
EVALUATING ALTERNATIVE REGISTRATION METHODS AND REFERENCE PLANES FOR IMAGELESS, COMPUTER-ASSISTED NAVIGATION DURING SUPINE TOTAL HIP ARTHROPLASTY (2023)

Imageless computer navigation systems have the potential to improve acetabular cup position in total hip arthroplasty (THA), thereby reducing the risk of revision surgery. This study aimed to evaluate the accuracy of three alternate registration planes in the supine surgical position generated using imageless navigation for patients undergoing THA via the direct anterior approach (DAA). Fifty-one participants who underwent a primary THA for osteoarthritis were assessed in the supine position using both optical and inertial sensor imageless navigation systems. Three registration planes were recorded: the anterior pelvic plane (APP) method, the anterior superior iliac spines (ASIS) functional method, and the Table Tilt (TT) functional method. Post-operative acetabular cup position was assessed using CT scans and converted to radiographic inclination and anteversion. Two repeated measures analysis of variance (ANOVA) and Bland-Altman plots were used to assess errors and agreement of the final cup position. For inclination, the mean absolute error was lower using the TT functional method (2.4°±1.7°) than the ASIS functional method (2.8°±1.7°, ρ = .17), and the ASIS anatomic method (3.7°±2.1, ρ &lt; .001). For anteversion, the mean absolute error was significantly lower for the TT functional method (2.4°±1.8°) than the ASIS functional method (3.9°±3.2°, ρ = .005), and the ASIS anatomic method (9.1°±6.2°, ρ &lt; .001). All measurements were within ± 10° for the TT method, but not the ASIS functional or APP methods. A functional registration plane is preferable to an anatomic reference plane to measure intra-operative acetabular cup inclination and anteversion accurately. Accuracy may be further improved by registering patient location using their position on the operating table rather than anatomic landmarks, particularly if a tighter target window of ± 5° is desired.
Seroepidemiological Studies of Transfusion-Associated Hepatitis (1971)

Journal Article Seroepidemiological Studies of Transfusion-Associated Hepatitis Get access R. H. Purcell, R. H. Purcell Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Walsh, J. H. Walsh Search for other works by this author on: Oxford Academic PubMed Google Scholar P. V. Holland, P. V. Holland Search for other works by this author on: Oxford Academic PubMed Google Scholar A. G. Morrow, A. G. Morrow Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Wood, S. Wood Search for other works by this author on: Oxford Academic PubMed Google Scholar R. M. Chanock R. M. Chanock Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 123, Issue 4, April 1971, Pages 406–413, https://doi.org/10.1093/infdis/123.4.406 Published: 01 April 1971 Article history Received: 17 September 1970 Revision received: 07 January 1971 Published: 01 April 1971
Development of a GCN-based model to predict <i>in vitro</i> phototoxicity from the chemical structure and HOMO-LUMO gap (2023)

The interaction between sunlight and drugs can lead to phototoxicity in patients who have received such drugs. Phototoxicity assessment is a regulatory requirement globally and one of the main toxicity screening steps in the early stages of drug discovery. An in silico-in vitro approach has been utilized mainly for toxicology assessments at these stages. Although several quantitative structure-activity relationship (QSAR) models for phototoxicity have been developed, in silico technology to evaluate phototoxicity has not been well established. In this study, we attempted to develop an artificial intelligence (AI) model to predict the in vitro Neutral Red Uptake Phototoxicity Test results from a chemical structure and its derived information. To accomplish this, we utilized an open-source software library, kMoL. kMoL employs a graph convolutional neural networks (GCN) approach, which allows it to learn the data for the specified chemical structure. kMoL also utilizes the integrated gradient (IG) method, enabling it to visually display the substructures contributing to any positive results. To construct this AI model, we used only the chemical structure as a basis, then added the descriptors and the HOMO-LUMO gap, which was obtained from quantum chemical calculations. As a result, the assortment of chemical structures and the HOMO-LUMO gap produced an AI model with high discrimination performance, and an F1 score of 0.857. Additionally, our AI model could visualize the substructures involved in phototoxicity using the IG method. Our AI model can be applied as a toxicity screening method and could enhance productivity in drug development.
Nanomaterials for Wound Healing: Scope and Advancement (2015)

Innovative methods for treating impaired and hard-to-heal wounds are needed. Novel strategies are needed for faster healing by reducing infection, moisturizing the wound, stimulating the healing mechanisms, speeding up the wound closure and reducing scar formation. In the past few years, nanotechnology has been constantly revolutionizing the treatment and management of wound care, by offering novel solutions which include but are not limited to: state-of-the-art materials, so called 'smart' biomaterials and theranostic nanoparticles. Nanotechnology-based therapy has recently announced itself as a possible next-generation therapy that is able to advance wound healing to cure chronic wounds. In this communication, the recent progress in advanced therapy for cutaneous wound healing during last 5 years using a nanotechnology-based approach is summarized.
Spiral transmission-line baluns for RF multichip module packages (1999)

We describe a design method and lumped model for a circular spiral transmission-line balun. All lumped values are extracted from the geometric parameters of the balun. From simulation, the design parameters with well predicted characteristics are defined. The balun is fabricated using multi-chip module processing technology, which is suitable for integration in RF packages. Measurements show a wide bandwidth of 1.5-4.1 GHz and excellent balanced outputs. Amplitude imbalance less than 0.5 dB and phase imbalance less than 4/spl deg/ are achieved. The simulation results are compared with the measurement. The model captures all important properties of the balun with reasonably high accuracy.
900V silicon carbide MOSFETs for breakthrough power supply design (2015)

Improvements in 900V SiC MOSFET technology have resulted in switches that have extremely low ON resistance in high-speed packages. 900V SiC MOSFETs are promising candidates for hard switched and soft-switched power supply applications due to low ON resistance at higher temperature, a robust low-recovery body diode, avalanche capability and low output stored charge. System designers will be able to use these features to enable novel topologies and achieve large improvements in power density and efficiency. As an example, a 220 W single-stage flyback LED driver is presented, which achieves 40% size reduction over a 650V silicon MOSFET based solution, obtains similar efficiencies and a lower BOM cost.
Security Analysis of the ADS Protocol of a Beckhoff CX2020 PLC (2017)

ICSs (Industrial Control Systems) and its subset SCADA systems (Supervisory Control and Data Acquisition) are getting exposed to a constant stream of new threats. The increasing importance of IT security in ICS requires viable methods to assess the security of ICS, its individual components, and its protocols. This paper presents a security analysis with focus on the communication protocols of a single PLC (Programmable Logic Controller). The PLC, a Beckhoff CX2020, is examined and new vulnerabilities of the system are revealed. Based on these findings recommendations are made to improve security of the Beckhoff system and its protocols.
Observation of a Resonant Structure near the Ds+Ds− Threshold in the B+→Ds+Ds−K+ Decay (2023)

: An amplitude analysis of the B^{+}→D_{s}^{+}D_{s}^{-}K^{+} decay is carried out to study for the first time its intermediate resonant contributions, using proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7, 8, and 13 TeV. A near-threshold peaking structure, referred to as X(3960), is observed in the D_{s}^{+}D_{s}^{-} invariant-mass spectrum with significance greater than 12 standard deviations. The mass, width, and the quantum numbers of the structure are measured to be 3956±5±10 MeV, 43±13±8 MeV, and J^{PC}=0^{++}, respectively, where the first uncertainties are statistical and the second systematic. The properties of the new structure are consistent with recent theoretical predictions for a state composed of cc[over ̄]ss[over ̄] quarks. Evidence for an additional structure is found around 4140 MeV in the D_{s}^{+}D_{s}^{-} invariant mass, which might be caused either by a new resonance with the 0^{++} assignment or by a J/ψφ↔D_{s}^{+}D_{s}^{-} coupled-channel effect.
Cover Picture: Plasma Process. Polym. 6∕2015 (2015)

Front Cover: An atmospheric pressure diffuse dielectric barrier discharge between cylindrical rotary electrodes was applied for deposition of silica-like moisture barrier films on polymer foil. The discharge was operated in N2/O2/Ar gas mixture with the addition of tetraethyl orthosilicate. It is shown that high quality permeation barrier films can be deposited by atmospheric pressure roll-to-roll process. Further details can be found in the article by Sergey A. Starostin et. al. on page 545.
HARDWARE INDUSTRY PERSPECTIVE (1998)

In discussing the hardware industry perspective on roadside safety testing procedures, this presentation addresses the following questions: What has National Cooperative Highway Research Program (NCHRP) Report 350 done for you? Are the test criteria too severe? Where are we deficient in our evaluation of current products? At the Federal Highway Administration's (FHWA's) discretion, manufacturers may and often are required to run non-standard tests before the FHWA Approval Letter will be issued - is this good practice? And, in conclusion, are we headed in the right direction?
Solving Constraints on the Intermediate Result of Decimal Floating-Point Operations (2007)

The draft revision of the IEEE Standard for Floating- Point Arithmetic (IEEE P754) includes a definition for decimal floating-point (FP) in addition to the widely used binary FP specification. The decimal standard raises new concerns with regard to the verification of hardware- and software-based designs. The verification process normally emphasizes intricate corner cases and uncommon events. The decimal format introduces several new classes of such events in addition to those characteristic of binary FP. Our work addresses the following problem: Given a decimal floating-point operation, a constraint on the intermediate result, and a constraint on the representation selected for the result, find random inputs for the operation that yield an intermediate result compatible with these specifications. The paper supplies efficient analytic solutions for addition and for some cases of multiplication and division. We provide probabilistic algorithms for the remaining cases. These algorithms prove to be efficient in the actual implementation.
Growth of Hybrid Inorganic/Organic Chiral Thin Films by Sequenced Vapor Deposition (2019)

One of the many challenges in the study of chiral nanosurfaces and nanofilms is the design of accurate and controlled nanoscale films with enantioselective activity. Controlled design of chiral nanofilms creates the opportunity to develop chiral materials with nanostructured architecture. Molecular layer deposition (MLD) is an advanced surface-engineering strategy for the preparation of hybrid inorganic-organic thin films, with a desired embedded property; in our study this is chirality. Previous attempts to grow enantioselective thin films were mostly focused on self-assembled monolayers or template-assisted synthesis, followed by removal of the chiral template. Here, we report a method to prepare chiral hybrid inorganic-organic nanoscale thin films with controlled thickness and impressive enantioselective properties. We present the use of an MLD reactor for sequenced vapor deposition to produce enantioselective thin films, by embedding the chirality of chiral building blocks into thin films. The prepared thin films demonstrate enantioselectivity of ∼20% and enantiomeric excess of up to 50%. We show that our controlled synthesis of chiral thin films generates opportunities for enantioselective coatings over various templates and 3D membranes.
Regioselective monochloro substitution in carbohydrates and non-sugar alcohols via Mitsunobu reaction: applications in the synthesis of reboxetine (2013)

A regioselective high yielding monochloro substitution (chlorohydrin formation) via Mitsunobu reaction is reported. In carbohydrates and sterically hindered non-sugars, only the primary hydroxyl group is chlorinated, whereas in the non-sugar 1,2- and 1,3-alcohols, predominantly the secondary chloride substitution occurs. The versatile methodology provides indirect access to epoxides with the retention of configuration, as against conventional Mitsunobu reaction which generates epoxides with inversion. The methodology was successfully used as a key step in the synthesis of optically active diastereoisomers of the antidepressant drug reboxetine from (R)-2,3-O-cyclohexylidene-d-glyceraldehyde in ∼43% overall yields.
Mechanism of Ion Transport by Fluorescent Oligoester Channels (2012)

The synthesis and membrane activity of a suite of linear oligoesters containing a common diphenylacetylene unit core and differing in the hydroxyl terminus are reported. Active compounds formed high-conductance channels efficiently in both vesicle and planar bilayers, with one compound showing a very unusual slow loss of transport activity over a 20-30 min period. Steady-state and time-resolved fluorescence studies establish the rapid partition of active compounds to the bilayer and identify at least three types of membrane-associated species by their differing fluorescence lifetimes. The change in the distribution of species is correlated with the slow loss of activity. The results are interpreted in terms of an aggregate within a single bilayer leaflet that is nonetheless competent to transport ionic species through the bilayer. The properties of such structures, revealed by these compounds, appear to be consistent with commonly observed behaviors of other synthetic ion channels.
Impact of Preoperative Metatarsus Adductus on Surgical Correction after Triplanar Tarsometatarsal Arthrodesis (2020)

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Early radiographic outcomes of hallux valgus correction focusing on multiplanar deformity have shown promising results. Surgical correction for patients with preexisting metatarsus adductus is considered more challenging and results in higher recurrence rates following hallux valgus surgery. The purpose of this study was to evaluate the impact of preoperative metatarsus adductus on surgical correction following triplanar first tarsometatarsal (TMT) arthrodesis with early weightbearing for hallux valgus. Methods: A retrospective review was performed of 57 patients (62 feet) aged 39.7 +- 18.9 years who underwent triplanar first TMT arthrodesis between 2015 and 2017 at four institutions. After the operation, patients were allowed early full weightbearing in a walking boot. Patients were grouped based on preoperative metatarsus adductus angles for comparison. Preoperative imaging was reviewed and compared to radiographic imaging at 12 months postoperative. Hallux valgus angle (HVA), intermetatarsal angle (IMA), tibial sesamoid position (TSP), lateral round sign, and sesamoid subluxation (axial) were evaluated. For statistical analysis, one-way analysis of variance (ANOVA) and chi-square tests were performed using JMP 11.0.0 (SAS Institute Inc., Cary, NC). Results: Patients with a preoperative metatarsus adductus angle greater than 20 degrees had significantly higher HVA at 12 months (p = 0.0165). There were no differences in IMA or TSP at 12 months based on preoperative metatarsus adductus (p = 0.7687 and p = 0.8703, respectively). Overall recurrence rate for hallux valgus was 3.2% (2/62 patients), and both of these patients had a preoperative metatarsus adductus greater than 20 degrees. There was significantly more sesamoid axial subluxation at 12 months for patients with preoperative metatarsus adductus greater than 20 degrees (p = 0.0092). Overall, the symptomatic non- union rate was 1.7% (1/62 patients). Conclusion: Preoperative metatarsus adductus greater than 20 degrees resulted in higher HVA and recurrence rates at 12 months after triplanar tarsometatarsal arthrodesis. For patients with preexisting metatarsus adductus, additional consideration should be given to ensure the sesamoids are properly reduced under the crista. Future studies should compare the long-term impact of metatarsus adductus on surgical correction, recurrence, and complications after triplanar tarsometatarsal arthrodesis.
Probing the long-term thrombotic safety of mRNA COVID-19 vaccines by image-based single-cell monitoring of platelet activity (2022)

A global concern has been raised about extremely rare, but serious cases of a thrombotic disorder, known as COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT), associated with the Oxford-AstraZeneca and Johnson &amp; Johnson / Janssen COVID-19 vaccines. While the pathogenesis of VITT remains not fully understood, a currently accepted theory is that the adenoviral vector vaccines produce antibodies that recognize platelet factor 4 (PF4), leading to platelet activation and aggregation, followed by thromboembolic complications. Therefore, the recommended methods of evaluation for VITT include complete blood count, anti-PF4-heparin antibody enzyme-linked immunosorbent assay, coagulation tests, and medical imaging. However, none of these methods can directly probe platelet activity (i.e., platelet activation and aggregation) and study potential non-PF4 factors for increased platelet activity. Here we report a method for directly probing vaccine-induced platelet activity and hence assessing the risk of VITT at its early stage. Specifically, we used the method to demonstrate image-based single-cell profiling and temporal monitoring of platelet aggregates (thrombosis risk) in the blood of healthy human subjects before and after receiving multiple Pfizer-BioNTech vaccine shots in a time span of nearly a year. Results show that the average concentration of platelet aggregates in healthy subjects after the first, second, and third vaccinations is comparable to that before the first vaccination and is lower than that in COVID-19 patients, indicating that the vaccine-induced platelet activity and potential risk of VITT in the healthy subjects were found to be low.
Proposal of Assist Section Determination Method for Wire Type Walking Assist Suit Based on Hip Joint Angle (2020)

In recent years, with the serious aging society, research on assist suits is being conducted. In order to setting the optimum assist timing for each user, we proposed a method to determine the assist timing for wire type assist suit. In this method, since the assist timing is determined based on the hip joint angular acceleration by the IMU sensor. Specifically, the assist range is defined by the standard deviation of the point which the positive/negative value of thigh acceleration is reversed to the point that the positive/negative value of acceleration is reversed again, and the two timings when the sign of the differential value of the angular acceleration is inverted is defined as the maximum tension timing. As a result of the experiment using the assist timing created by this method, the effectiveness of the created assist timing was shown from the results of the hip joint angle and the hip joint torque.
Cyclohexane oxidation using Au/MgO: an investigation of the reaction mechanism (2012)

The liquid phase oxidation of cyclohexane was undertaken using Au/MgO and the reaction mechanism was investigated by means of continuous wave (CW) EPR spectroscopy employing the spin trapping technique. Activity tests aimed to determine the conversion and selectivity of Au/MgO catalyst showed that Au was capable of selectivity control to cyclohexanol formation up to 70%, but this was accompanied by a limited enhancement in conversion when compared with the reaction in the absence of catalyst. In contrast, when radical initiators were used, in combination with Au/MgO, an activity comparable to that observed in industrial processes at ca. 5% conversion was found, with retained high selectivity. By studying the free radical autoxidation of cyclohexane and the cyclohexyl hydroperoxide decomposition in the presence of spin traps, we show that Au nanoparticles are capable of an enhanced generation of cyclohexyl alkoxy radicals, and the role of Au is identified as a promoter of the catalytic autoxidation processes, therefore demonstrating that the reaction proceeds via a radical chain mechanism.
Helicobacter pylori and the null genotype of glutathione-S-transferase-? in patients with gastric adenocarcinoma (1998)

The null genotype for GST-mu is found more commonly in gastric carcinoma associated with H. pylori infection. The absence of the GST-mu enzyme may increase the risk of the development of gastric carcinoma in these patients.