gebhart/patrepeval huggingface dataset:
Recent Clinical Advances in the Management of Critically Ill Patients with Acute Renal Failure (2006)

Based on recent clinical studies, the increasing use of the RIFLE criteria is justified, as this approach appears to be a robust method for both the diagnosis of and prognostication in ARF. A large randomized trial involving convective CRRT supports the commonly used prescription of 35 ml/ kg/h in clinical practice. Moreover, numerous recent outcome studies, also largely involving convective CRRT, provide a clinical rationale for the increasingly common clinical practice of earlier initiation. Finally, several recent studies suggest CRRT, relative to conventional hemodialysis, results in a greater rate of renal recovery in ARF patients.
Data Supplement from SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38<sup>+</sup> Hematologic Malignancies (2023)

&lt;p&gt;Supplementary Figure S2. Close-up view of the salt-bridges interactions between huCD38 and the heavy-chain of SAR650984-Fab&lt;/p&gt;
Green Photoluminescence of Perovskite CsPb(Br1–xIx)3 Nanocrystals for Wide Color Gamut Displays (2019)

All-inorganic mixed-halide CsPb(Br<sub>1-<i>x</i></sub> I <sub><i>x</i></sub> )<sub>3</sub> perovskite nanocrystals (NCs) are excellent candidates for green-emitting phosphors in wide color gamut displays; however, a detailed investigation of their photoluminescence (PL) properties based on the halide composition has been missing. In this work, we report a fundamental investigation of the changes in the PL properties of CsPb(Br<sub>1-<i>x</i></sub> I <sub><i>x</i></sub> )<sub>3</sub> NCs. The PL color of the NCs, which were prepared by a hot-injection method, changed from green to red with increasing iodide composition (<i>x</i>). Almost ideal green emission close to the chromaticity coordinates of the green vertex of the BT.2020 standard was achieved by appropriately substituting iodide ions for bromide ions in monohalide CsPbBr<sub>3</sub> NCs. However, the PL peak width of the mix-halide NCs at <i>x</i> ∼ 0.5 was 0.127 eV, which was broader than the 0.105 eV peak width of the monohalide CsPbBr<sub>3</sub> NCs. This phenomenon should be due to the compositional inhomogeneity among the individual CsPb(Br<sub>1-<i>x</i></sub> I <sub><i>x</i></sub> )<sub>3</sub> NCs. On the other hand, the PL quantum yield (PLQY) for the monohalide CsPbBr<sub>3</sub> NCs decreased from 70 to 25% as <i>x</i> increased to 0.5. This result may be attributed to lattice distortion by the difference in the ionic radii of bromide and iodide. Improvements in the compositional inhomogeneity and lattice distortion would enhance the color purity of the green emission and the PLQY, respectively, of the CsPb(Br<sub>1-<i>x</i></sub> I <sub><i>x</i></sub> )<sub>3</sub> NCs.
Bacteroides thetaiotaomicronAmeliorates Colon Inflammation in Preclinical Models of Crohn’s Disease (2018)

B. thetaiotaomicron displays strong efficacy in preclinical models of IBD and protects against weight loss, histopathological changes in the colon and inflammatory markers. These data indicate that the live strain or its products may be a novel alternative to current treatment options for Crohn's disease.
Simulation-based design of a micro fluidic transportation system for mobile applications based on ultrasonic actuation (2018)

Enabling efficient gas transport by small and integrated microsystems became of major interest and gained momentum since much more attention is paid to controlling the air quality in urban areas by the general public. In order to be able to locally detect low concentrations of gases or particulate matter (PM) being potentially harmful to health, e.g. by sensors incorporated in mobile devices, small and energy efficient micropumps are needed to increase the throughput of ambient air and in that way the measurement frequency. In this work, we propose the concept of an ultrasound-based microfluidic pump. In a first step, we evaluate actuation patterns in simple analytic pressure field simulations in order to investigate and design a phased array with tunable radiation angle. Then, the simulation models are extended to fully coupled finite element models (FEM) by taking into account fluid-solid interaction as well. However, upscaled prototypes showed no measurable gas transport. Taking into account our findings, subsequent FEM simulations with rectifying elements in the fluidic channel are conducted. In the end, we compare the efficiency of single-membrane actuators with multi-membrane actuators running in phase as well as out of phase.
2.5 GHz Wide Band Linear Amplifier with Feedforward Lineariser on a Board (2002)

A wide band feedforward lineariser amplifier we have developed is described. In particular, we report the IM3 improvement obtained without automatic adaptive control circuits, indicating the possibility of realizing small, low-cost products. We designed a lineariser amplifier for 2.5 GHz band to demonstrate the effectiveness of our approach and measurement revealed the wide band linearising capability of over 100 MHz.
Sub-micron opto-chemical probes for studying living neurons (2017)

We have fabricated sub-micron opto-chemical probes for pH, oxygen and calcium monitoring and demonstrated their application in intracellular and extracellular monitoring of neurons (cortical neuronal cultures and acute hippocampal slices). Using these probes, we have measured extracellular pH in the stratum radiatum of the CA1 region of mouse hippocampus upon stimulation of presynaptic Schaffer collateral axons. Synaptic transmission was monitored using standard electrophysiological techniques. We find that the local pH transiently changes in response to synaptic stimulation. In addition, the geometry of the functionalized region on the probe combined with high sensitivity imaging enables simultaneous monitoring of spatially adjacent but distinct compartments. As proof of concept we impaled cultured neurons with the probe measured calcium and pH inside as well as directly outside of neurons as we changed the pH and calcium concentration in the physiological solution in the perfusion chamber. As such these probes can be used to study the impact of the environment on both cellular and extra-cellular space. Additionally as the chemical properties of the surrounding medium can be controlled and monitored with high precision, these probes enable differential measurement of the target parameter referenced to a stable bath. This approach eliminates the uncertainties associated with non-chemical fluctuations in the fluorescent emission and result in a self-calibrated opto-chemical probe. We have also demonstrated multifunctional probes that are capable of measuring up to three parameters in the extracellular space in brain slices.
High-dimensional Multivariate Mediation: with Application to\n Neuroimaging Data (2015)

Mediation analysis has become an important tool in the behavioral sciences\nfor investigating the role of intermediate variables that lie in the path\nbetween a randomized treatment and an outcome variable. The influence of the\nintermediate variable on the outcome is often explored using structural\nequation models (SEMs), with model coefficients interpreted as possible\neffects. While there has been significant research on the topic in recent\nyears, little work has been done on mediation analysis when the intermediate\nvariable (mediator) is a high-dimensional vector. In this work we present a new\nmethod for exploratory mediation analysis in this setting called the directions\nof mediation (DMs). The first DM is defined as the linear combination of the\nelements of a high-dimensional vector of potential mediators that maximizes the\nlikelihood of the SEM. The subsequent DMs are defined as linear combinations of\nthe elements of the high-dimensional vector that are orthonormal to the\nprevious DMs and maximize the likelihood of the SEM. We provide an estimation\nalgorithm and establish the asymptotic properties of the obtained estimators.\nThis method is well suited for cases when many potential mediators are\nmeasured. Examples of high-dimensional potential mediators are brain images\ncomposed of hundreds of thousands of voxels, genetic variation measured at\nmillions of SNPs, or vectors of thousands of variables in large-scale\nepidemiological studies. We demonstrate the method using a functional magnetic\nresonance imaging (fMRI) study of thermal pain where we are interested in\ndetermining which brain locations mediate the relationship between the\napplication of a thermal stimulus and self-reported pain.\n
Synthesis, crystal structure, and characterization of cyclohexylammonium tetraisothiocyanatocobaltate(II): A single-source precursor for cobalt sulfide and oxide nanostructures (2019)

We successfully synthesized 3D supramolecular structure of cyclohexylammonium tetraisothiocyanatocobaltate(II) complex, (C<sub>6</sub>H<sub>11</sub>NH<sub>3</sub>)<sub>2</sub>[Co(NCS)<sub>4</sub>], in almost a quantitative yield by using metathesis and ligand addition reactions. The new complex was characterized by various techniques such as FTIR, UV-Visible, PXRD, SXRD, and CV electrochemical analysis to investigate mainly its structure. Based on the results of these techniques, the formation of the desired complex was confirmed. The TGA for this complex indicated the utilization of this complex as a single-source precursor for the synthesis of cobalt sulfide (CoS) under helium atmosphere and tricobalt tetraoxide (Co<sub>3</sub>O<sub>4</sub>) under air. Investigation of pyrolysis products by PXRD proved the formation of CoS and Co<sub>3</sub>O<sub>4</sub>. Furthermore, morphology studies by SEM and TEM displayed the formation of CoS and Co<sub>3</sub>O<sub>4</sub> nanoparticles with various shapes.
Method for the Automatic Detection of Epileptiform Waveforms in Sevoflurane-induced Anesthesia EEG (2006)

Sevoflurane is a volatile anesthetic which is reported to cause epileptiform EEG changes together with undesired symptoms such as convulsions. In this paper, an algorithm for the automatic detection of these EEG changes is presented which could enable safer induction of anesthesia with sevoflurane by informing the clinicians about the epileptiform EEG. EEG was recorded from 60 healthy female patients during sevoflurane anesthesia. A neurophysiologist classified the EEG waveforms. Each anesthesia period lasted 6 minutes. 48 signal features were extracted from the raw EEG. 5-sec segments of EEG were classified based on the extracted features using a decision tree with a logistic regression based decisions and the classification results were compared to the neurophysiologist's classifications. Awake EEG was recognized with 69% / 96% (sensitivity / specificity), Burst suppression with 56% / 98%, Epileptiform EEG with 83% / 87 %, normal slow anesthesia EEG with 86% / 64 %, slow anesthesia EEG with monophasic pattern with 65% / 80 %, and slow anesthesia EEG with monophasic pattern and spikes with 54% / 84%.
Medulloblastoma in a Child with Rubenstein-Taybi Syndrome: Case Report and Review of the Literature (2001)

Although medulloblastoma is usually sporadic, there are a number of uncommon predisposing germline mutation syndromes, including: Gorlin's Syndrome, Turcot's Syndrome and Li-Fraumeni Syndrome. Patients with Rubenstein-Taybi Syndrome secondary to mutation/deletion of the CBP gene on chromosome 16 are predisposed to a variety of developmental anomalies as well as cancer. We report a child with Rubenstein-Taybi syndrome who developed a cerebellar medulloblastoma and review the literature on Rubenstein-Taybi Syndrome and pediatric medulloblastoma. As the product of the CBP gene functions in a variety of signaling pathways, we discuss the molecular implications of findings a medulloblastoma in a child with Rubenstein-Taybi Syndrome.
A traffic density model for radio overlapping in urban Vehicular Ad hoc Networks (2011)

Vehicular traffic density is a key factor in determining the behaviour of radio overlapping and thus impacts performance of data and safety message communication in Vehicular Ad hoc Networks (VANETs). In this paper, we propose a novel density model for urban traffic systems and employ this model for the purpose of spatial-temporal analysis of radio overlapping. To model traffic density, we consider a signalized junction and road segments linked to that junction as basic building blocks of urban traffic systems. The density model enables us to derive a framework to explain trends and critical regions of radio overlapping corresponding to VANET scenarios targeted for urban transportation systems, which cannot be derived from uniform density models widely used in existing literature. We apply the derived radio overlapping model to study channel load associated with periodic beaconing, a fundamental mechanism for safety message communication in VANETs. This study also provides a generic analytical framework to investigate other performance aspects of data and safety message communication in VANETs. Our experimental results using the proposed realistic density model demonstrate the need for an adaptive mechanism to adjust transmission power and data rate to reduce channel loads associated with dense traffic conditions.
The fractal Hilbert monopole: A two‐dimensional wire (2002)

Abstract A novel miniature antenna based on the fractal Hilbert geometry is presented. The antenna becomes electrically smaller as the fractal iteration increases at a higher rate than that of any other fractal geometry presented until now. Several fractal‐shaped Hilbert monopoles have been constructed, measured, and compared with the classical λ/4 monopole. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 102–104, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10687
Regression Bugs Are In Your Model! Measuring, Reducing and Analyzing Regressions In NLP Model Updates (2021)

Yuqing Xie, Yi-An Lai, Yuanjun Xiong, Yi Zhang, Stefano Soatto. Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing (Volume 1: Long Papers). 2021.
Implications of doping on microstructure, processing, and thermoelectric performance: The case of PbSe (2021)

Abstract In this work, we highlight the often-overlooked effects of doping on the microstructure and performance of bulk thermoelectric materials to offer a broader perspective on how dopants interact with their parent material. Using PbSe doped with Na, Ag, and K as a model material system, we combine original computational, experimental, and microscopy data with established trends in material behavior, to provide an in-depth discussion of the relationship between dopants, processing, and microstructure, and their effects on thermoelectric efficiency and thermal stability. Notable observations include differences in the microstructure and mass loss of thermally treated samples of Na- and Ag-doped PbSe, as well as findings that Na and K cations exist predominantly as substitutional point defects while Ag also occupies interstitial sites and exhibits lower solubility. We discuss how these differences in point defect populations are known to affect a dopants’ ability to alter carrier concentration and how they may affect the mechanical properties of PbSe during processing. Graphic Abstract
Effect of Dopant on Piezoelectric Properties of Lead-Free BiFeO3–BaTiO3Film (2011)

To realize high-performance lead-free piezoelectric materials, we have selected BiFeO3 as the rhomboheral phase material and BaTiO3 as the tetragonal phase material, following the MPB mechanism of PZT. To further improve the piezoelectric properties of BiFeO3–BaTiO3 (BFBT) thin films, we investigated the effect of dopant on the piezoelectric properties of BFBT. Considering both Shanon effective ionic radii and valence number, we have selected Sr2+ (BFBT–SrTiO3, abbreviated as BFBT-ST) and Nb5+ (abbreviated as BFBT-Nb) substitutions. BFBT-ST and BFBT-Nb films were epitaxially grown by pulsed laser deposition on an epitaxial SrRuO3/MgO/Si(100) substrate. The piezoelectric constant d33AFM is estimated from the slope of the maximum displacement and the maximum voltage strength by atomic force microscopy. Compared with 0.8BF0.2BT films with d33AFM = 65 pm/V, the 0.8BF0.2BT–Nb2.5% films achieved d33AFM = 78 pm/V. The displacement curve of 0.8BF0.2BT–Nb2.5% became soft with the occurrence of a hysteresis shape, compared with that of 0.8BF0.2BT. Moreover, the d33AFM of 0.77BF0.13BT–0.1ST (BF/BT ratio= 0.85/0.15) was 83 pm/V, compared with the d33AFM (58 pm/V) of 0.85BF0.15BT. According to these results, we confirmed that the Sr2+ and Nb5+ substitutions improve the piezoelectric properties of BFBT.
Immunoelectron microscopic localization of idiotypes and allotypes on immunoglobulin molecules. (1982)

We have developed a novel approach to the analysis of antigenic (allotypic and idiotypic) determinants on intact immunoglobulin molecules. Immune complexes composed of IgG in combination with anti-idiotype or anti-allotype antibody were "visualized" by transmission electron microscopy. Individual Fab fragments of anti-idiotype or anti-allotype antibody, when bound to the IgG, altered the "Y" configuration in a reproducible and interpretable manner. Anti-idiotype antibody (either as Fab or IgG) bound to the terminus of the presumed V region of the IgG molecule, thus extending the apparent length of the Fab arms. Analysis of a rabbit VH framework allotype (a1) revealed that the determinant(s) is (are) located on the lateral portion of the V region of IgG. Binding of the anti-a1 Fab fragments was always at approximately right angles to the axis of the Fab arms of IgG. Fab antibody to the rabbit kappa light chain (b4) allotype bound to the lateral portion of the terminal half of the IgG Fab arms. This technique should be of value in localizing less well defined immunoglobulin determinants.
THE VIROME OF RHIPICEPHALUS, DERMACENTOR AND HAEMAPHYSALIS TICKS FROM EASTERN ROMANIA INCLUDES NOVEL VIRUSES WITH POTENTIAL RELEVANCE FOR PUBLIC HEALTH (2021)

Ticks are involved in the transmission of various pathogens and some tick-borne diseases cause significant problems for the health of humans and livestock. Despite their obvious importance, the composition of viral communities in ticks, and their interactions with pathogens, is poorly understood, particularly in Eastern Europe that constitutes (via bird migrations for example) a major hub for animal-arthropod vectors exchanges. The aim of this study was first to describe the virome of Dermacentor sp., Rhipicephalus sp. and Haemaphysalis sp. ticks collected from poorly investigated regions of Romania (Iasi and Tulcea counties) located at the intersection of various biotopes, countries and routes of migrations. We then focused the study on viruses that could have potential relevance for human and animal health. More than 500 ticks were collected in 2019 from the environment and from small ruminants and analyzed by high-throughput transcriptome sequencing. Among the viral communities infecting Romanian ticks, viruses belonging to the Flaviviridae, Phenuiviridae and Nairoviridae families were identified and full genomes were derivedPhylogenetic analyses placed them in clades where mammalian isolates are found, suggesting that these viruses could constitute novel arboviruses. We also assessed the bacterial microbiome of the collected ticks. The characterization of these microbial communities increases the knowledge of the diversity of viruses in Eastern Europe and provide a basis for further studies on the relationship between ticks and tick-borne viruses.
Physical Mechanism of the Mechanical Bending of High-Performance Organic TFTs and the Effect of Atmospheric Factors (2022)

In this paper, we investigate the electrical characteristics of organic thin-film transistors (OTFTs) after mechanical bending stress conducted in a range of different atmospheres. After 100,000 cycles of channel-width-axis compressive bending and a long-term fixed curve at a bending radius of R = 5 mm in an atmospheric environment, the threshold voltage (VT) is seen to shift in the positive direction. Following annealing after bending, the VT recovers to a value more negative than the initial VT for both dynamic and static bending tests. Performing bending tests in a vacuum, which eliminates the influence of the ambient atmosphere on the OTFTs, shows that the degradation of the device under atmospheric bending is dominated by two mechanisms. Gasses present in the ambient environment (humidity, N2, CO2, and O2) are introduced sequentially to understand their effect on the OTFTs. By studying the effects in the vacuum and atmosphere, we are able to separate the physical effects of mechanical bending on the OTFTs from the changes induced by exposure to environmental factors. Due to different mechanical bending conditions, the small molecules at the surface of the active layer cause different electrical characteristics. Finally, a physical model of mechanical bending and atmospheric factors for organic TFTs is proposed.
Poor Physical Performance and Dementia in the Oldest Old (2012)

We found a strong cross-sectional relationship between poor physical performance and dementia in people 90 years and older. Our findings suggest that dementia is a complex neurodegenerative process that may affect physical performance and cognition. Additional research is necessary to determine the temporal relationship between poor physical performance and cognitive dysfunction.
Accuracy of free energies of hydration using CM1 and CM3 atomic charges (2004)

Absolute free energies of hydration (DeltaGhyd) have been computed for 25 diverse organic molecules using partial atomic charges derived from AM1 and PM3 wave functions via the CM1 and CM3 procedures of Cramer, Truhlar, and coworkers. Comparisons are made with results using charges fit to the electrostatic potential surface (EPS) from ab initio 6-31G* wave functions and from the OPLS-AA force field. OPLS Lennard-Jones parameters for the organic molecules were used together with the TIP4P water model in Monte Carlo simulations with free energy perturbation theory. Absolute free energies of hydration were computed for OPLS united-atom and all-atom methane by annihilating the solutes in water and in the gas phase, and absolute DeltaGhyd values for all other molecules were computed via transformation to one of these references. Optimal charge scaling factors were determined by minimizing the unsigned average error between experimental and calculated hydration free energies. The PM3-based charge models do not lead to lower average errors than obtained with the EPS charges for the subset of 13 molecules in the original study. However, improvement is obtained by scaling the CM1A partial charges by 1.14 and the CM3A charges by 1.15, which leads to average errors of 1.0 and 1.1 kcal/mol for the full set of 25 molecules. The scaled CM1A charges also yield the best results for the hydration of amides including the E/Z free-energy difference for N-methylacetamide in water.
Optical imaging applied to microelectronic chip-to-chip interconnections (1985)

An imaging system is proposed as an alternative to metallized connections between integrated circuits. Power requirements for metallized interconnects and electrooptic links are compared. A holographic optical element is considered as the imaging device. Several experimental systems have been constructed which have visible LEDs as the transmitters and PIN photodiodes as the receivers. Signals are evaluated at different source-detector separations. Multiple exposure holograms are used as a means of optical fan out allowing one source to simultaneously address several receiver locations. Limitations of this technique are also discussed.