gebhart/patrepeval huggingface dataset:
Abstract 4572: Heterodimerization of CD74 and CD20 by two hexavalent, bispecific, anti-CD20/CD74 antibodies leads to potent cytotoxicity in mantle cell lymphoma (2011)

Abstract Hexavalent antibodies (HexAbs) comprising four Fabs of one specificity linked to a full IgG of the same or a different specificity can be successfully generated by the Dock-and-Lock (DNL) method to retain the binding activity of each constitutive Fab. Whereas HexAbs made from veltuzumab (anti-CD20) and epratuzumab (anti-CD22) show direct toxicity in several B-cell non-Hodgkin lymphomas (NHL) in vitro, they are ineffective against mantle cell lymphoma (MCL) lines expressing similar levels of CD20 and CD22. In this study, we describe the properties of two novel HexAbs, one comprising veltuzumab linked to four Fabs of milatuzumab (anti-CD74), designated 20-(74)-(74), and the other comprising milatuzumab linked to four Fabs of veltuzumab, designated 74-(20)-(20). Both 20-(74)-(74) and 74-(20)-(20) potently inhibited the growth of MCL lines (JeKo-1, Granta-519, and Mino), chronic lymphocytic leukemia lines (WAC and MEC), and NHL lines (Daudi and Raji) at 10 nM in the MTS cell proliferation assay, without the need for crosslinking by a secondary antibody. In contrast, anti-proliferative activity was noted in Jeko-1 and other cell lines for the parental antibodies or the two monospecific HexAbs, 74-(74)-(74) and 20-(20)-(20), only in the presence of a secondary antibody to effect hypercrosslinking, suggesting the requirement of heterodimerization of CD74 and CD20 for the observed cytotoxicity. Additional experiments showed the two anti-CD20/CD74 HexAbs induced substantial apoptosis (25 to 30%) in Jeko-1 and Granta-519, which appeared to accompany significant changes in mitochondrial membrane potential, detectable generation of reactive oxygen species, pronounced phosphorylation of ERK and JNK MAP kinases, and downregulation of Bcl-xL, but not with activation of caspases or the involvement of autophagy. A key differentiation of the anti-CD20/CD74 HexAbs from the anti-CD20/CD22 HexAbs is the ability of the former to induce strong homotypic adhesion of the MCL lines, but not the latter or the respective parental antibodies. Immunofluorescence revealed 74-(20)-(20) internalized slower than 20-(74)-(74), which may account for the consistently higher potency of 74-(20)-(20) than 20-(74)-(74). We also found that pretreatment with C16, an agonistic anti-CD74 antibody known to promote cell proliferation, or macrophage migration-inhibitory factor (MIF), the pro-survival ligand of CD74, did not abrogate the growth inhibition induced by the anti-CD20/CD74 HexAbs. The potent in vitro cytotoxicity of the anti-CD20/CD74 HexAbs against MCL lines warrants their further evaluation in B-cell lymphomas that are refractory or poorly responsive to anti-CD20 or anti-CD22 antibodies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4572. doi:10.1158/1538-7445.AM2011-4572
Inference of letter-phoneme correspondences by delimiting and dynamic time warping techniques (1992)

An algorithm for inferring correspondences between letters and phonemes from a large set of word spellings and their associated phonemic forms is described. The algorithm uses two techniques to infer correspondences: delimiting and dynamic time warping (DTW). The first technique delimits the part of the word spelling and pronunciation that cannot be aligned with the existing set of correspondences. The second technique derives correspondences from the delimited part of that word. The inferred correspondences are evaluated in terms of translation performance tested with unseen words, proper names and novel words. The translation performance is compared with those obtained using the manually driven correspondences as the benchmark. Nonparametric statistical tests are used to establish whether the performances of inferred correspondences are significantly different from the manually derived correspondences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Multifunctional lignin-based nanocomposites and nanohybrids (2021)

Significant progress in lignins valorization and development of high-performance sustainable materials have been achieved in recent years. Reports related to lignin utilization indicate excellent prospects considering green chemistry, chemical engineering, energy, materials and polymer science, physical chemistry, biochemistry, among others. To fully realize such potential, one of the most promising routes involves lignin uses in nanocomposites and nanohybrid assemblies, where synergistic interactions are highly beneficial. This review first discusses the interfacial assembly of lignins with polysaccharides, proteins and other biopolymers, for instance, in the synthesis of nanocomposites. To give a wide perspective, we consider the subject of hybridization with metal and metal oxide nanoparticles, as well as uses as precursor of carbon materials and the assembly with other biobased nanoparticles, for instance to form nanohybrids. We provide cues to understand the fundamental aspects related to lignins, their self-assembly and supramolecular organization, all of which are critical in nanocomposites and nanohybrids. We highlight the possibilities of lignin in the fields of flame retardancy, food packaging, plant protection, electroactive materials, energy storage and health sciences. The most recent outcomes are evaluated given the importance of lignin extraction, within established and emerging biorefineries. We consider the benefit of lignin compared to synthetic counterparts. Bridging the gap between fundamental and application-driven research, this account offers critical insights as far as the potential of lignin as one of the frontrunners in the uptake of bioeconomy concepts and its application in value-added products.
Process to Etch Ni and Pt Residues during Silicide Contact Electrode Processing Using Low Temperature Aqueous Solutions (2013)

During NiPtSi contact electrode processing and after the first thermal treatment to form Ni rich silicide, excessive Ni is removed by a strong acid mixture such as piranha (mixture of sulfuric acid and hydrogen peroxide. The post salicidation clean process has to be selective to all exposed materials: Si3N4, SiO2, NiPtSi, and NiPtSiGe (contact electrodes of source/drain for strain applications)). Performing a partition process with RTA1 (rapid thermal annealing) followed by Ni strip, followed by RTA2, and then with Pt strip is one method to check for NiPt removal. The Ni strip was performed using dilute nitric acid (20:1) and dilute aqua regia (1:5:4) and showed completed NiPt removal. A queue time study was also investigated after the Ni strip and after RTA2 for defect formation. Also, Pt removal using aqua regia solutions of various shelf-lives were tested. The result led to the conclusion that solutions of aqua regia with longer shelf-lives were also shown to be less effective in Pt residue removal. Using a High Productivity Combinatorial materials/process screening technique to reduce the number of product wafers used for evaluation process development, the etch rates of all the materials of interest were tested on blanket wafers. The chemistry consists of varying acid and base types and the relative combinations of these chemistries. Process conditions that consisted of various process chemistries, process temperatures, and degrees of fluid agitation (e.g. stirrer speed) were done on the same substrate.
Oncological outcomes of radical cystectomy for bladder cancer: Laparoscopy versus open surgery (2009)

e16059 Background: To compare the oncological outcomes of laparoscopic versus open surgery in radical cystectomy for bladder cancer. Methods: A prospective non-randomized study was conducted between January 2003 and November 2008 in 52 patients, 2 women and 50 men, who underwent radical cystectomy for bladder cancer. Thirty seven cystectomies were carried out by laparoscopic surgery (LS) and 15 by open surgery (OS). Mean patient age was 67.3 ± 9.7 years. The median preoperative ASA score was 2 (1–3) in both groups. Kaplan-Meier curves were constructed to estimate the survival rate for the whole sample. Datas were compared by Log-rank test. Current followup, overall and specific deaths were used as endpoints. The survival time was defined as the time elapsed from the date of radical cystectomy to the endpoint. Results: All tumours were transitional cell carcinoma, high-grade and stage &lt; pT3b pN0. One patient of OS group had a positive surgical margin. Eight patients (15.4%), 7 of LS group and 1 of OS group, completed 5 years of follow-up. At the last follow-up 40 patients (76.9%) were alive with no evidence of disease and 5 (9.6%) died, two patients (3.8%) from metastasis and 3 (5.7%) from different causes. No patient developed port- site metastasis. Overall survival was significantly better in LS group than in the OS group (p=0.039). No statistical difference was noted for Specific survival. Mean patient follow-up was 30.9 ± 20.3 months. Conclusions: The data suggest that LRC provides oncological outcomes comparable to contemporary series of open RC. No significant financial relationships to disclose.
First observation of the decays B0bar -> D+ K− pi+ pi− and B− -> D0 K− pi+ pi− (2012)

First observations of the Cabibbo-suppressed decays ¯¯¯ B 0 → D + K − π + π − and B − → D 0 K − π + π − are reported using 35 pb − 1 of data collected with the LHCb detector. Their branching fractions are measured with respect to the corresponding Cabibbo-favored decays, from which we obtain B ( ¯¯¯ B 0 → D + K − π + π − ) / B ( ¯¯¯ B 0 → D + π − π + π − ) = ( 5.9 ± 1.1 ± 0.5 ) × 10 − 2 and B ( B − → D 0 K − π + π − ) / B ( B − → D 0 π − π + π − ) = ( 9.4 ± 1.3 ± 0.9 ) × 10 − 2 , where the uncertainties are statistical and systematic, respectively. The B − → D 0 K − π + π − decay is particularly interesting, as it can be used in a similar way to B − → D 0 K − to measure the Cabibbo-Kobayashi-Maskawa phase γ .
Anomalous ABO Phenotype in a Child after an ABO-Incompatible Liver Transplantation (1992)

RED-CELL A and B antigens are primarily intrinsic membrane glycoproteins that become attached during erythropoiesis by specific A and B transferase enzymes.1 A and B antigens may also be acquired by red-cell adsorption of A and B substances present in the plasma of secretors.2 The acquisition or loss of ABO antigens has been reported in association with cancers, hematologic disorders, infections, and bone marrow transplantation.3 Except in emergencies, the compatibility of the donor's and the recipient's ABO blood types is ensured in liver transplantation.4 5 6 In this report we describe a successful ABO-incompatible liver transplantation in a child whose blood type . . .
A novel method for fabrication of integrated shadow mask for patterning electrode in passive matrix OLED displays (2005)

This paper reports a novel method for making an integrated shadow mask used in fabrication of passive matrix OLED displays. Common positive and negative photoresists were employed to produce retrograded strip pillars with large overhang and undercut by photolithography. The pillar strips serve as an effective shadow mask for patterning the organic layers and the metal cathodes in OLED display devices. It is expected that this method can significantly enhance the performance of passive matrix OLED at a low shadow mask fabrication cost. The method can be used for fabricating more complicated structures for other display applications.
Role of the Anion on the Transport and Structure of Organic Mixed Conductors (2018)

Abstract Organic mixed conductors are increasingly employed in electrochemical devices operating in aqueous solutions that leverage simultaneous transport of ions and electrons. Indeed, their mode of operation relies on changing their doping (oxidation) state by the migration of ions to compensate for electronic charges. Nevertheless, the structural and morphological changes that organic mixed conductors experience when ions and water penetrate the material are not fully understood. Through a combination of electrochemical, gravimetric, and structural characterization, the effects of water and anions with a hydrophilic conjugated polymer are elucidated. Using a series of sodium‐ion aqueous salts of varying anion size, hydration shells, and acidity, the links between the nature of the anion and the transport and structural properties of the polymer are systematically studied. Upon doping, ions intercalate in the crystallites, permanently modifying the lattice spacings, and residual water swells the film. The polymer, however, maintains electrochemical reversibility. The performance of electrochemical transistors reveals that doping with larger, less hydrated, anions increases their transconductance but decreases switching speed. This study highlights the complexity of electrolyte‐mixed conductor interactions and advances materials design, emphasizing the coupled role of polymer and electrolyte (solvent and ion) in device performance.
Combustion Oscillations Close to the Lean Flammability Limit (2000)

The nature of premixed methane-air flames stabilised on a symmetric, plane sudden-expansion has been examined in terms of wall pressures and the chemiluminescence of the CH radical. Large-amplitude acoustic oscillations at the half-wave frequency of the entire duct were observed at high velocities and with near-stoichiometric mixtures, and instabilities with much lower-frequencies close to the lean and rich extinction limits. The emphasis is on these near-limit instabilities and, due to the asymmetry of the plane flow, the experiments were extended to round ducts in which the flammability and stability limits were similar to those in the plane duct. The branches of flame behind the steps of the plane expansion extinguished non-simultaneously, and gave rise to low-frequency flapping oscillations immediately prior to extinction of the first of these, and the remaining branch gave rise to lateral oscillations prior to its extinction. The oscillations were associated with axial movement of extinction along the shear layer due to the high strain rates close to the step, until the strain rate was sufficiently low and allowed upstream propagation of the flame through the recirculation region. The flames in the round duct gave rise to oscillations of the same nature. The frequency of the oscillations increased with flow velocity and flame speed, and the amplitude with heat release and much more with constriction of the duct exit due to coupling with a bulk-mode of the combustor cavity. These increased amplitudes caused the flammability limits to narrow due to the consequently higher strain rates and have implications for gas turbine operation.
Phosphonic Acid-Functionalized Polyurethane Dispersions with Improved Adhesion Properties (2015)

A facile route to phosphorus-functionalized polyurethane dispersions (P-PUDs) with improved adhesion properties is presented. (Bis)phosphonic acid moieties serve as adhesion promoting sites that are covalently attached via an end-capping reaction to isocyanate-reactive polyurethane particles under aqueous conditions. The synthetic approach circumvents solubility issues, offers great flexibility in terms of polyurethane composition, and allows for the synthesis of semicrystalline systems with thermomechanical response due to reversible physical cross-linking. Differential scanning calorimetry (DSC) is used to investigate the effect of functionalization on the semicrystallinity. The end-capping conversion was determined via inductively-coupled plasma optical emission spectroscopy (ICP-OES) and was surprisingly found to be almost independent of the stoichiometry of reaction, suggesting an adsorption-dominated process. Particle charge detection (PCD) experiments reveal that a dense surface coverage of phosphonic acid groups can be attained and that, at high functionalization degrees, the phosphonic adhesion moieties are partially dragged inside the colloidal P-PUD particle. Quartz crystal microbalance with dissipation (QCMD) investigations conducted with hydroxyapatite (HAP) and stainless steel sensors as model surfaces show a greatly enhanced affinity of the aqueous P-PUDs and furthermore indicate polymer chain rearrangements and autonomous film formation under wet conditions. Due to their facile synthesis, significantly improved adhesion, and variable film properties, P-PUD systems such as the one described here are believed to be of great interest for multiple applications, e.g., adhesives, paints, anticorrosion, or dentistry.
Gallium-arsenide optically isolated electric field sensor for utility and pulsed power applications (2002)

An optically isolated microminiature electric field sensor based on the Franz-Keldysh effect in gallium arsenide is described. The sensor is suitable for a variety of high-voltage remote sensing electric utility applications, such as field mapping in substations, power line voltage measurement and voltage calibration of high-voltage laboratory diagnostics. Data demonstrating absolute calibration of the field sensor at electric fields in GaAs as low as 5 kV/cm is presented. A system that eliminates temperature drift during line-frequency measurements is described.
New efficient light guide for interior illumination (1982)

Experimental and theoretical studies of the recently patented prism light guide are described [L. A. Whitehead, U.S. Patent 4,260,220 (7 Apr. 1981)]. This device combines the total internal reflection of optical fibers with the low attenuation of air transmission of light. Since it can be moulded from acrylic plastic, the cost of the guide is low enough to make large-scale interior illumination with piped light feasible.
Transmit Precoder Design Approaches for Dual-Function\n Radar-Communication Systems (2022)

As radio-frequency (RF) antenna, component and processing capabilities\nincrease, the ability to perform multiple RF system functions from a common\naperture is being realized. Conducting both radar and communications from the\nsame system is potentially useful in vehicular, health monitoring, and\nsurveillance settings. This paper considers multiple-input-multiple-output\n(MIMO) dual-function radar-communication (DFRC) systems in which the radar and\ncommunication modes use distinct baseband waveforms. A transmit precoder\nprovides spatial multiplexing and power allocation among the radar and\ncommunication modes. Multiple precoder design approaches are introduced for a\nradar detection mode in which a total search volume is divided into dwells to\nbe searched sequentially. The approaches are designed to enforce a reliance on\nradar waveforms for sensing purposes, yielding improved approximation of\ndesired ambiguity functions over prior methods found in the literature. The\nmethods are also shown via simulation to enable design flexibility, allowing\nfor prioritization of either subsystem and specification of a desired level of\nradar or communication performance.\n
Results in non-iterative MAP reconstruction for optical tomography (2008)

Maximum a posteriori (MAP) estimation has been shown to be an effective method for reconstructing images from optical diffusion tomography data. However, one disadvantage of MAP reconstruction is that it typically requires the use of iterative methods which are computationally intensive. However, the direct reconstruction of MAP images is possible when the forward model is linear (or linearized) and the noise and image prior are assumed Gaussian. These non-iterative MAP reconstruction techniques only require the multiplication of an inverse matrix by a data vector to compute the reconstruction, but they depend on a combination of lossy source coding techniques and sparse matrix transforms to make the required matrix-vector product computation both computationally and memory efficient. In this paper, we show examples of how non-iterative MAP reconstruction methods can be used to dramatically reduce computation and storage for MAP reconstruction. Simulations of fluorescence optical diffusion tomography (FODT) measurements and corresponding reconstructions are used to demonstrate the potential value of these techniques. Numerical examples show the non-iterative MAP reconstruction can substantially reduce both storage and computation, as compared to traditional iterative reconstruction methods.
3D finite element analysis of large deformations in polycristals as a first step for mesoscopic modelling of primary recrystallization (2009)

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Dynamic imaging of BHV cuspal motion using laser projection (2003)

Quantification of cusp deformation is essential in understanding the mechanisms leading to bioprosthetic heart valve (BHV) failure. A novel experimental method utilizing a laser projection technique to investigate dynamic cuspal motion is presented. In a mock circulatory loop, a 19/spl times/19 matrix of laser dots was projected on to the surface of the valve cusps. A system of multiple cameras was employed to track the dots at various temporal points of the opening and the closing of the valve during the cardiac cycle. To obtain unobstructed views of the entire cuspal surface, including the basal region, high resolution boroscopes were used. The cusp surface at each temporal point was reconstructed in three dimensions. Apart from being non-contacting, the current method can reconstruct the entire surface of the cusp simultaneously. In addition to BHV studies, this approach is potentially applicable in investigations using bioreactor technology for tissue engineered heart valves.
A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes (1999)

T cells involved in autoimmune diseases have been characterized by the genetic elements used to construct their autoimmune TCR. In the present study, we sequenced the alpha and beta chains of the TCR expressed by a CD4(+) T cell clone, C9, functional in NOD mouse diabetes. Clone C9 can adoptively transfer diabetes or, when attenuated, C9 can be used to vaccinate NOD mice against diabetes. Clone C9 recognizes a peptide epitope (p277) of the 60 kDa heat shock protein (hsp60) molecule. We now report that the C9 TCR beta chain features a CDR3 peptide sequence that is prevalent among NOD mice. This CDR3 element is detectable by 2 weeks of age in the thymus, and later in the spleen and in the autoimmune insulitis. Thus, a TCR CDR3beta sequence appears to be a common idiotope associated with mouse diabetes.
ChemInform Abstract: Self‐Assembly of Fullerene Tubes and Balls (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parametric macromodeling of integrated inductors for RF circuit design (2017)

ABSTRACT Nowadays, parametric macromodeling techniques are widely used to describe electromagnetic structures. In this contribution, the application of such parametric macromodeling techniques to the design of integrated inductors and radio‐frequency circuit design is investigated. In order to allow such different operations, a new modeling methodology is proposed, which improves the modeling accuracy when compared to former techniques. The new methodology is tailored to the unique characteristics of the devices under study. The obtained parametric macromodel is then used in a synthesis methodology and in the design of a voltage controlled oscillator in a 0.35‐μm CMOS technology. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1207–1212, 2017