gebhart/patrepeval huggingface dataset:
High Speed Circuits for Short Reach Optical Communications (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Rylyakov, "High Speed Circuits for Short Reach Optical Communications," in Optical Fiber Communication Conference, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper Tu3G.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation (2013)

Living tissue engineered heart valves (TEHV) may circumvent ongoing problems in pediatric valve replacements, offering optimum hemodynamic performance and the potential for growth, remodeling, and self-repair [1]. TEHV have been constructed by seeding vascular-derived autologous cells onto biodegradable scaffolds and exhibited enhanced extracellular matrix (ECM) development when cultured under pulsatile flow conditions in-vitro [2]. After functioning successfully for up to 8 months in the pulmonary circulation of growing lambs, TEHV underwent extensive in vivo remodeling and structural evolution and have demonstrated the feasibility of engineering living heart valves in vitro [3]. The employment of novel cell sources, which are clinically obtainable in principle such as bone marrow-derived mesenchymal stem cells (MSCs), is key to achieve viable clinical application [4].
Novel Electrocatalysts for Oxygen Reduction Using Cobaltporphyrins That Undergo Facile Electropolymerization (2006)

電解重合性を有する新しいコバルトポルフィリンとして, メソテトラ (3-チエニル) ポルフィリナトコバルト (II) を3-チエニルアルデヒドとピロールから合成した. グラッシーカーボン電極への電解重合により, コバルトポルフィリンがπ共役系の2,5-チエニレン連鎖で連結された導電性ポルフィリン薄膜を得た. これを介した溶存酸素の電解還元を行うと, サイクリックボルタンメトリーにおいてEp=0.2V vs. SCE付近に酸素還元由来の電流ピークが観測された. この方法では, 従来の吸着によるポルフィリン修飾炭素電極に比べ, 重合膜を形成するため安定度の高い修飾電極が得られることが分かった. 触媒担体として比表面積の大きいカーボンブラックを択び, 電解液に分散させた条件下でコバルトポルフィリンの電解重合を行うと, 炭素粒子の表面にコバルトポルフィリンの重合膜を形成可能であることを見いだした. 得られた修飾炭素粒子をNafion溶液に分散させ, 基盤電極上にキャストすることにより擬似MEA (膜電極接合体) を作製した. これを用いた酸素還元反応では, 貴な電位 (Ep=0.44V vs. SCE) および反応選択度 (反応電子数n =3.8) で酸素の四電子還元が進行することが明らかになった. また, 得られた触媒を不活性ガス雰囲気下で熱処理するとさらなる活性向上が認められ (Ep=0.47V vs. SCE, n =3.8), 燃料電池における白金に拠らない新しいカソード触媒としての可能性が示された.
[Problems in tobacco smoking in opinion of VI year of medical students]. (2006)

1. There were 12.7% of daily smoking students including 8.6% women and 15% men. 2. Almost 79% volunteers ineffectively attempted to give up smoking within last year. 3. The smoking students abused alcohol (with high likelihood) and used recreational drugs twice more than nonsmoking colleagues. 4. Almost all volunteers (96.4%) want to use smoking cessation intervention in their patients. 5. Above 75% students declared to broaden their knowledge about diagnostic and smoking cessation therapy.
Doped Perovskites To Evaluate the Relationship between Fuel–Oxidizer Thermite Ignition and Bond Energy, Electronegativity, and Oxygen Vacancy (2016)

Despite our knowledge of the existence of the violent thermite reaction for over 100 years, it is still not yet understood how the properties of a metal oxide oxidizer relate to and influence the ignition temperature. To address this shortcoming, we prepared a series of perovskite-based oxidizers which enable a systematic investigation of how materials properties of the oxidizer relate to the ignition temperature. In this paper, nine lanthanum-based perovskites with different Sr2+ doping of the A-site and different B-site transition metals were synthesized. The perovskite O2 release and ignition temperatures with aluminum were measured by fast heating (>105 K/s) temperature-jump/time-of-flight mass spectrometry coupled with high-speed imaging. These results were then correlated with the average bond energy and overall metal–oxygen electronegativity difference. Remarkably, we found a linear relationship between average bond energy and electronegativity with ignition temperature. To our knowledge this is the first demonstration of the connection between metal–oxygen bond energy, electronegativity, and ignition temperature.
Isolation von zirkulierenden Tumorzellen (CTC) bei Lungenkarzinompatienten mithilfe eines CellCollectors - erste Pilotuntersuchungen (2013)

Einleitung: In der Lungenkarzinom-Diagnostik, -Verlaufsbeobachtung und -Forschung besteht ein Bedarf an einfach zugänglichem Tumormaterial. Hierfür könnten zirkulierende Tumorzellen (CTC) aus dem Blut geeignet sein. Die wesentliche Herausforderung ist die Isolation bzw. Anreicherung dieser Zellen. Eine Möglichkeit ist die Verwendung eines CellCollectors. Dieser basiert auf einem funktionalisierten Edelstahldraht, der in vivo in eine Armvene eingeführt wird, um CTC aus dem Blutstrom zu isolieren. Die Interaktion der CTC mit dem CellCollector erfolgt über kovalent an ein biokompatibles Hydrogel gebundene, gegen EpCam (epithlial cell adhesion molecule) gerichtete Antikörper. Diese Methode hat in einzelnen Indikationen (z.B. Prostata-Karzinom) bereits in Studien seine Leistungsfähigkeit gezeigt.
Correction: Fluvastatin Interferes with Hepatitis C Virus Replication via Microtubule Bundling and a Doublecortin-like Kinase-Mediated Mechanism (2013)

Hepatitis C virus (HCV)-induced alterations in lipid metabolism and cellular protein expression contribute to viral pathogenesis. The mechanism of pleiotropic actions of cholesterol-lowering drugs, statins, against HCV and multiple cancers are not well understood. We investigated effects of fluvastatin (FLV) on microtubule-associated and cancer stem cell marker (CSC), doublecortin-like kinase 1 (DCLK1) during HCV-induced hepatocarcinogenesis. HCV replication models, cancer cell lines and normal human hepatocytes were used to investigate the antiviral and antitumor effects of statins. FLV treatment resulted in induction of microtubule bundling, cell-cycle arrest and alterations in cellular DCLK1 distribution in HCV-expressing hepatoma cells. These events adversely affected the survival of liver-derived tumor cells without affecting normal human hepatocytes. FLV downregulated HCV replication in cell culture where the ATP pool and cell viability were not compromised. Pravastatin did not exhibit these effects on HCV replication, microtubules and cancer cells. The levels of miR-122 that regulates liver homeostasis and provides HCV genomic stability remained at steady state whereas DCLK1 mRNA levels were considerably reduced during FLV treatment. We further demonstrated that HCV replication was increased with DCLK1 overexpression. In conclusion, unique effects of FLV on microtubules and their binding partner DCLK1 are likely to contribute to its anti-HCV and antitumor activities in addition to its known inhibitory effects on 3-hydroxy-3methylglutary-CoA reductase (HMGCR).
Using Reinforcement Learning to Allocate and Manage SFC in Cellular Networks (2020)

In this paper, we propose the use of reinforcement learning to deploy a service function chain (SFC) of cellular network service and manage the VNFs operation. We consider that the SFC is deployed by the reinforcement learning agent considering a scenario with distributed data centers, where the virtual network functions (VNFs) are deployed in virtual machines in commodity servers. The VNF management is related to create, delete, and restart the VNFs. The main purpose is to reduce the number of lost packets taking into account the energy consumption of the servers. We use the Proximal Policy Optimization (PPO2) algorithm to implement the agent and preliminary results show that the agent is able to allocate the SFC and manage the VNFs, reducing the number of lost packets.
Dynamic Mechanism Design with Interdependent Valuations (2015)

We consider an infinite horizon dynamic mechanism design problem with interdependent valuations. In this setting the type of each agent is assumed to be evolving according to a first order Markov process and is independent of the types of other agents. However, the valuation of an agent can depend on the types of other agents, which makes the problem fall into an interdependent valuation setting. Designing truthful mechanisms in this setting is non-trivial in view of an impossibility result which says that for interdependent valuations, any efficient and ex-post incentive compatible mechanism must be a constant mechanism, even in a static setting. Mezzetti (2004) circumvents this problem by splitting the decisions of allocation and payment into two stages. However, Mezzetti's result is limited to a static setting and moreover in the second stage of that mechanism, agents are weakly indifferent about reporting their valuations truthfully. This paper provides a first attempt at designing a dynamic mechanism which is efficient, `strict' ex-post incentive compatible and ex-post individually rational in a setting with interdependent values and Markovian type evolution.
DYNAMIQUE MOLECULAIRE CLASSIQUE (2002)

1. Introduction&lt;br /&gt;2. Potentiels interatomiques&lt;br /&gt;3. Implémentation de la dynamique moléculaire
Violable Contracts and Governance for Blockchain Applications (2018)

We examine blockchain technologies, especially smart contracts, as a platform for decentralized applications. By providing a basis for consensus, blockchain promises to upend business models that presuppose a central authority. However, blockchain suffers from major shortcomings arising from an over-regimented way of organizing computation that limits its prospects. We propose a sociotechnical, yet computational, perspective that avoids those shortcomings. A centerpiece of our vision is the notion of a declarative, violable contract in contradistinction to smart contracts. This new way of thinking enables flexible governance, by formalizing organizational structures; verification of correctness without obstructing autonomy; and a meaningful basis for trust.
Observations regarding DNA replication sites in human cells in vivo following infusions of iododeoxyuridine and bromodeoxyuridine (1991)

In studies using bromodeoxyuridine (BrdUrd) and/or iododeoxyuridine (IdUrd) to label S phase cells in cancer patients, several unique observations were made regarding DNA replication sites and the organization of newly synthesized DNA in post-mitotic cells. While the majority of tumour specimens removed at the end of infusions demonstrated concentration of replication sites around the nuclear membrane, biopsies obtained in leukaemic patients 1 week later demonstrated several distinct patterns of labelling. For example, one, two or all lobes of granulocytes were labelled. Scavenger macrophages bearing labelled leukaemic cells in their cytoplasm were also seen. Sequential IdUrd/BrdUrd labelling of solid tumours showed various patterns of nuclear/nucleolar/membrane labelling, allowing more precise localization of early versus late replication sites.
Proceedings of the first edition workshop on Politics, elections and data (2012)

It is our pleasure to welcome you to the first edition of the Politics, Elections and Data workshop (PLEAD at CIKM 2012). goal of this workshop, taking place a few days before the 2012 U.S. presidential elections, is to bring together researchers working at the intersection of social network analysis, computational social science and political science, to share and discuss their ideas in a common forum; and to inspire further developments in this growing, fascinating field of computational political science.

The call for papers attracted submissions from researchers in different areas and from different countries, which underscores the wide appeal of computational political science. program committee accepted 6 papers which cover a variety of topics: measuring the online popularity of political campaigns, the adoption of social networking platforms by members of the political class and the feasibility of characterizing political communities by tracking topics in the message streams of their members, analyzing patterns in candidate funding to discern the state of a political party, mining opinions on politically controversial topics and finally, analyzing the effects of voter microtargeting and proposing solutions for mitigating the more worrisome aspects.

In addition, the program includes a keynote speech from Filippo Menczer on The Diffusion of Political Memes in Social Media. Filippo presents ongoing work on the study of information diffusion in social media with a focus on polarization, cross-ideological communication and partisan asymmetries in online political activities. workshop will also feature a presentation of existing online tools for political analysis and a panel discussion with industry, academia and media participants.
Synthesis and Pharmacological Activity of Deltorphin and Dermorphin-Related Glycopeptides (1997)

The solid phase procedure, based on the Fmoc chemistry, was used to prepare some opioid deltorphin (H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2, DEL C) and dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2, DER) analogues in which a D-glucopyranosyl moiety is beta-O-glycosidically linked to a Thr4 or Thr7 side chain. Their activities were determined in binding studies based on displacement of mu- and delta-receptor selective radiolabels from rat brain membrane synaptosomes, in guinea pig ileum and rabbit jejenum bioassays, and, in vivo, by a mouse tail-flick test after intracerebroventricular (icv) and subcutaneous (sc) administrations. The glyco analogues modified at position 4 displayed low opioid properties, while Thr7-glycosylated peptides retained high delta- or mu-selectivity and remarkable activity in vivo. In particular, as systemic antinociceptive agents, the latter glucoside-bearing compounds were more potent than the parent unglycosylated peptide counterparts, showing a high blood to brain rate of influx which may be due to the glucose transporter GLUT-1.
Ultimate performance of the RSFQ logic circuits (1987)

A new family of dc-powered Josephson junction digital devices, the Rapid Single Flux Quantum (RSFQ) logic, is described. The devices use overdamped Josephson junctions and two-junction interferometers to store, pass and process the digital information presented in form of single flux quanta. We have carried out extensive numerical simulation of the dynamics of the RSFQ logic gates and of some more complex circuits including serial full adder and reversible shift register, within the standard microscopic-theory ("Werthamer") description of Josephson junctions. The minimum clock cycles of the basic RSFQ circuits turn out to be as small as 2.5 ps. The most promising ways to use the RSFQ logic circuits at the present stage of development of the Josephson junction digital technology are discussed.
Platelets in Regeneration (2010)

Platelets, as the first cellular response after disruption of vascular and/or tissue integrity, cover any existing injury within our body. But is the regenerative potential of platelets limited to providing a cellular patch for wounds? This review highlights the recent advance in our understanding of platelets being distinctly regulated and regulating cells that contribute immensely to the healing process from the very initial stage to the late events of tissue regeneration. For instance, the intrinsic actions of platelets as a regenerative cell, the participation of platelets in angiogenic processes, and the interplay of platelets and circulating stem and progenitor cells, as well as potential therapeutic implications, are addressed. Although we are starting to understand the underlying mechanisms connecting platelets to the components of tissue regeneration just mentioned, many aspects remain to be elucidated. The demand to invest research in this area is underscored by the fact that platelets or platelet-derived molecules are already applied in clinical contexts such as connective tissue regeneration, whereas other research fields have largely neglected platelet effects going beyond their participation in the coagulation cascade. Understanding the mechanisms connecting platelets to tissue regeneration, however, will inevitably open novel options in regenerative medicine.
Noble metal nanoparticles in biosensors: recent studies and applications (2016)

Abstract The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers and receptor immobilization, good ability for reaction catalysis and electron transfer, and good biocompatibility. MNPs can be used alone and in combination with other classes of nanostructures. MNP-based sensors can lead to significant signal amplification, higher sensitivity, and great improvements in the detection and quantification of biomolecules and different ions. Some recent examples of biomolecular sensors using MNPs are given, and the effects of structure, shape, and other physical properties of noble MNPs and nanohybrids in biosensor performance are discussed.
Biomimetic ion transport: on the mechanism of ion transport by an artificial ion channel mimic (1990)

The influx of cations into vesicles mediated by a synthetic transporter is coupled to proton efflux and may be quantified by a pH-stat technique. The dependence of the transport upon cation type and concentration, upon transporter concentration, and upon temperature has been examined. The synthetic transporter is closely similar to the natural channel forming compound gramicidin, and significantly different from the carrier valinomycin, with respect to the variables examined. Keywords: ion transport, vesicle membrane, channel, gramicidin, transport mechanism.
All-Digital PLL with Variable Loop Type Characteristics (2006)

A fully-digital frequency synthesizer for RF wireless applications has recently been proposed. It replaces the conventional VCO with a digitally-controlled oscillator with sufficiently fine frequency resolution. The conventional phase/frequency detector, charge pump and RC loop filter are replaced by a time-to-digital converter and a simple digital loop filter. In this paper, we present novel techniques used in the all-digital PLL to achieve ultra-fast frequency acquisition of < 50 mus while maintaining excellent phase noise and spurious performance during transmission and reception. This approach has been validated and incorporated in commercial single-chip Bluetooth and GSM radios realized in deep-submicron CMOS
ChemInform Abstract: Unprecedented Influence of Azides and the Effect of Bulky Groups on Zinc‐Induced Reductions of Deoxy Halogeno Sugars. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electric Grid Blackstart: Trends, Challenges, and Opportunities (2022)

This report studies the expected future state of the grid and recommends actions that can be taken to increase grid resiliency, improve system modeling, perform more extensive studies, enhance training activities, and perform industry outreach for the purpose of the blackstart capabilities of power systems. The report is a revised version of PNNL-29118
Baroreflex Sensitivity Might Predict Responders to Milrinone in Patients With Heart Failure (2010)

The phosphodiesterase III inhibitor milrinone (MIL) is considered to be effective for "wet and cold" heart failure. In some cases, however, the inotropic effects of milrinone are insufficient. A previous study suggested that baroreflex sensitivity (BRS) predicts the cases in which MIL increases left ventricular dp/dt. The aim of this study was to determine whether BRS measured using the spontaneous sequence method predicts the MIL responders. Twenty-four patients with "wet and cold" heart failure whose systolic blood pressure > 100 mmHg were enrolled. At 2 hours MIL improved dys-pnea, general fatigue, urine volume, and tricuspid regurgitant pressure gradient in 13 patients (responders; R group), whereas it failed to improve in 11 patients (nonresponders; NR group). BRS in the R group was significantly higher than that in the NR group prior to the MIL infusion. At 2 hours after the MIL infusion, BRS was further increased in the R group, but did not increase in the NR group. The sensitivity and specificity of BRS at a cut-off level of 5 ms/mmHg for the prediction of R group were 0.94 and 0.93, respectively. BRS might be useful for identifying potential responders to milrinone in patients with blood pressure-preserved "wet and cold" heart failure.
Flow for phase locked loop mixed signal simulation and characterization using behavioral modeling (2003)

In order to reduce the number of design iterations for complex mixed signal telecommunication ICs, prediction of noise at an early stage of a design is essential. This paper present a robust mixed signal design flow to model phase noise or jitter on a VCO based PLL circuit using a mixed signal hardware description language VHDL-AMS and to measure this jitter.
Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials (2016)

Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations-where observing outcomes is difficult-versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions-including ENM test concentrations-that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia.