gebhart/patrepeval huggingface dataset:
Procedimiento de obtención de sepiolitas modificadas y uso de sepiolitas en la obtención de emisores de semioquímicos con velocidad de emisión controlada (2002)

Referencia OEPM: P9801473.-- Fecha de solicitud: 08/07/1998.-- Titulares: Universidad Politécnica de Valencia (UPV), Consejo Superior de Investigaciones Científicas (CSIC).
Multiparametric Whole-body MRI with Diffusion-weighted Imaging and ADC Mapping for the Identification of Visceral and Osseous Metastases From Solid Tumors (2018)

We have demonstrated that multiparametric WB-MRI is feasible for oncologic staging to identify bony and visceral metastasis in breast, prostate, pancreatic, and colorectal cancers. WB-MRI can be tailored to fit the patient, such that an "individualized patient sequence" can be developed for a comprehensive evaluation for staging and response during treatment.
Low‐dose CT for the detection and classification of metastatic liver lesions: Results of the 2016 Low Dose CT Grand Challenge (2017)

Infrastructure and methodology were developed to rapidly estimate observer performance for liver metastasis detection in low-dose CT examinations of the liver after either image-based denoising or iterative reconstruction. The results demonstrated large differences in detection and classification performance between noise reduction methods, although the majority of methods provided some improvement in performance relative to the commercial quarter-dose images with no noise reduction applied.
Trends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015) (2021)

Rates of transdermal fentanyl utilisation and fatal fentanyl overdose across Australia increased between 2003 and 2015. Although transdermal fentanyl utilisation was consistently greater among females and older adults, rates of fatal fentanyl overdose were highest among younger males. Interventions to reduce extramedical use among this high-risk population group are necessary to minimise fentanyl-related harms.
Data mining cDNAs reveals three new single stranded RNA viruses in Nasonia (Hymenoptera: Pteromalidae) (2010)

We report three novel small RNA viruses uncovered from cDNA libraries from parasitoid wasps in the genus Nasonia. The genome of this kind of virus is a positive-sense single-stranded RNA with a 3' poly(A), which facilitates cloning from cDNAs. Two of the viruses, NvitV-1 and NvitV-2, possess a RNA-dependent RNA polymerase that associates them with the family Iflaviridae of the order Picornavirales. A third virus, NvitV-3, is most similar to the Nora virus from Drosophila. A reverse transcription-PCR method developed for NvitV-1 indicates that it is a persistent commensal infection of Nasonia.
Supplementary Figure Legends 1-4 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer (2023)

Supplementary Figure Legends 1-4 from Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer
Mapping likelihood of encountering humans: application to path planning in crowded environment (2017)

International audience
Attraction of Brachyspira pilosicoli to mucin (2009)

The anaerobic intestinal spirochaete Brachyspira pilosicoli colonizes the large intestine of various species, including humans. In the colon this spirochaete can penetrate the overlying mucus layer, attach by one cell end to the underlying enterocytes, and initiate localized colitis and diarrhoea. The aim of this study was to investigate whether, as part of the colonization process, B. pilosicoli is attracted to mucin. Fifteen B. pilosicoli strains isolated from humans, pigs, chickens and dogs, and a control strain of Brachyspira hyodysenteriae, were analysed for their ability to enter solutions of hog gastric mucin in an in vitro capillary tube assay. No significant attraction was detected with 1 % mucin, but some strains started to enter a 2 % solution, and attraction then increased with increasing concentrations to peak at around 6-8 % mucin. A similar increase was seen with B. hyodysenteriae, although this activity peaked at 6 % mucin and then declined, suggesting that the two species have different affinities for mucin. These mucin concentrations were much higher than those used in previous experimental studies with Brachyspira species. The viscosities of the 6-8 % mucin solutions were around 7-12 mPa s, which were similar to the measured viscosities of the mucus layer overlying the epithelium in the caecum and colon of experimental pigs. The strains varied in their motility, as assessed by their ability to enter tubes containing chemotaxis buffer, but there was no significant relationship between this motility and the extent of their ability to enter the mucin solutions. Different strains also had different propensities to enter the mucin solutions, but there were no consistent differences according to the host species of origin. B. pilosicoli strain 95/1000 was attracted towards a solution of d-serine, suggesting that chemotaxis was involved in the attraction to mucin; however, 95/1000 was also attracted to viscous solutions of polyvinylpyrrolidone (PVP), in a manner mirroring the response to mucin, and hence suggesting the involvement of viscotaxis in the attraction to mucin. B. hyodysenteriae B204 showed a similar viscotaxis to PVP. Further studies are required to determine whether the in vitro interaction of a given strain with mucin is a useful indicator of its in vivo colonization ability, and hence could be used as a potential marker for virulence.
Infrared laser beam temporal fluctuations: characterization and filtering (2005)

IR lasers are widely used in electro-optical applications, especially in detector characterization systems. These lasers can be extremely sensitive to fluctuations in the operational temperature of their cavity and other environmental factors. Due to these influences, the laser output signal normally fluctuates randomly. These variations make it difficult to characterize the laser waist position and exact focus, which in turn causes difficulty with detector measurement. We apply a multivariate statistical approach to characterize and filter these variations and to calculate the "best focus" of a carbon dioxide laser operating at 10.6 µm. Using this method, the "best focus" can be calculated with great accuracy and can be easily implemented during postsignal processing. Also, this technique can potentially be applied to other situations in which laser signal instability is significant.
Optimal Quasi-Monte Carlo Valuation OfDerivative Securities (2004)

For manyapplicationsofcomputationalfinance,theuse ofquasirandomsequences seems to providea faster rate of convergencethan pseudorandomsequences. However, at present there are only a few choices of quasirandom sequences. By scrambling a quasirandom sequence we can produce a family of related quasirandom sequences. Finding an optimal quasirandom sequence within this family is an interesting problem, as such optimal quasirandom sequences can be quite useful in applications. The process of finding such optimal quasirandom sequences is called the derandomization of a randomized (scrambled) family. In this paper, we summarize aspects of this technique and explore applications of optimal quasirandom sequences to evaluate a particular derivative security. We find that the optimal quasirandom sequences give promising results even for high dimensions.
Mutual Coupling Reduction Between Flexible MIMO Antennas (2014)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Counting on community in cyberspace (1999)

In this panel, a group of researchers, each of whom has either constructed tools for communicating and community building in cyberspace or studied the process, present their own work and critically evaluate each other's work. Our perspective explores the relationships between individual usage of these tools and the formation of lasting social relationships and groups. Each panelist presents a current research project that documents the empirical patterns of use and interaction with existing forms of social cyberspaces. The panelists comment on the ways in which the their findings cast new perspective on each other's findings and on the prospects for the formation of both online communities and physical communities augmented by online interaction.
Idiopathic parafoveal telangiectasis associated with a foveal pseudovitelliform lesion (2002)

Idiopathic parafoveal telangiectasis (IPT) and basal laminar drusen with pseudovitelliform lesions are both uncommon ocular findings.1,2 Gass classified parafoveal telangiectasis into several groups. Group 2 is characterised by bilateral acquired parafoveal telangiectasis that usually becomes clinically apparent later in life, in the fifth and sixth decade. The zones of telangiectasis tend to be symmetric and measure up to one disc diameter, with preferential involvement of the temporal parafoveal region. Typical findings are minimal retinal oedema, “right angle” veins, which drain the telangiectatic areas, underlying retinal pigment epithelial (RPE) alterations and superficial retinal refractile deposits. Gass has also described the development of a small, foveal yellow pseudovitelliform lesion in some patients, but no associated basal laminar drusen were noted.1 Abnormal blood glucose metabolism may play a part in the development of IPT.3

Basal laminar or cuticular drusen are focal thickenings of the basement membrane of the RPE. Although they are sometimes difficult to detect on clinical examination, these basal laminar drusen present a striking fluorescein angiographic picture of innumerable uniform, small, slightly raised, hyperfluorescent nodules.2 Patients with basal laminar drusen may develop a yellowish exudative macular detachment (“pseudovitelliform lesion”) that may resemble the foveal lesion characteristic of Best’s vitelliform dystrophy. In some cases, the yellow material may gravitate to the inferior part of the detachment, producing a “pseudohypopyon” appearance. Typically, the pseudovitelliform material shows progressive staining with fluorescein dye during the course of the angiogram.2

This case report …
Chemical Composition And In-Vitro Antimicrobial Activity Of The Essential Oils Of Three Greek Achillea Species (2002)

The chemical composition of the essential oils of Achillea holosericea, Achillea taygetea, Achillea fraasii was determined by GC/MS analysis. Among the ninety-five assayed constituents, camphor, borneol and 1,8-cineol were found to be the major components. The in-vitro antimicrobial activity of these essential oils was evaluated against six bacteria indicating that the first is totally inactive, while the other two possess moderate to strong activities mainly against the Gram negative strains. The essential oil of A. fraasii was also active against the tested pathogenic fungi.
T-shaped emitter metal heterojunction bipolar transistors for submillimeter wave applications (2004)

We report on the development of submillimeter wave transistors at JPL. The goal of the effort is to produce advance-reliable high frequency and high power amplifiers, voltage controlled oscillators, active multipliers, and high-speed mixed-signal circuits for space borne applications. The technology in development to achieve this is based on the Indium Phosphide (InP) Heterojunction Bipolar Transistor (HBT). The HBT is well suited for high speed, high power and uniform (across wafer) performance, due to the ability to tailor the material structure that electrons traverse through by well-controlled epitaxial growth methods. InP with its compatible lattice matched alloys such as indium gallium arsenide (InGaAs) and indium aluminium arsenide (InAlAs) provides for high electron velocities and high voltage breakdown capabilities. The epitaxial methods for this material system are fairly mature, however the implementation of high performance and reliable transistors are still under development by many laboratories. Our most recently fabricated, second generation mesa HBTs at JPL have extrapolated current gain cutoff frequency (FJ of 142GHz and power gain cutoff frequency (Fm,) of approximately 160GHz. This represents a 13% and 33% improvement of Ft and F, respectively, compared to the first generation mesa HBTs [l]. Analysis based on the University of California, Santa Barbara (UCSB) device model, RF device characteristics can be significantly improved by reducing base contact resistance and base metal contact width. We will describe our effort towards increasing transistor performance and yield.
Surface Modification of an Organic Photoconductor in an Electrophotographic Charging Environment (2010)

Prolonged exposure of a commercial organic photoconductor in a plasma environment corresponding to an industrial electrophotographic process caused the formation of a parasitic surface layer with properties that are different from the original photoconductor. The parasitic film consists of a heavily oxidized surface region and oxygen-free subsurface layer with a chemical composition similar to the original photoconductor but having a significantly different bonding arrangement. The formation of this film has been correlated with damage induced by the energetic particles and UV photons originating from the electrophotographic plasma discharge. An in-depth understanding of the formation and the properties of this parasitic layer could provide an effective means to overcome its detrimental impact on printing cost and quality.
Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study (2022)

Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the comparability of Ki67 measurement across corresponding core biopsy and resection specimen cases, and (ii) assess section to section differences in Ki67 scoring. Two sets of 60 previously stained slides containing 30 core-cut biopsy and 30 corresponding resection specimens from 30 estrogen receptor-positive breast cancer patients were sent to 17 participating labs for automated assessment of average Ki67 expression. The blocks were centrally cut and immunohistochemically (IHC) stained for Ki67 (MIB-1 antibody). The QuPath platform was used to evaluate tumoral Ki67 expression. Calibration of the DIA method was performed as in published studies. A guideline for building an automated Ki67 scoring algorithm was sent to participating labs. Very high correlation and no systematic error (p = 0.08) was found between consecutive Ki67 IHC sections. Ki67 scores were higher for core biopsy slides compared to paired whole sections from resections (p ≤ 0.001; median difference: 5.31%). The systematic discrepancy between core biopsy and corresponding whole sections was likely due to pre-analytical factors (tissue handling, fixation). Therefore, Ki67 IHC should be tested on core biopsy samples to best reflect the biological status of the tumor.
Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion (2020)

Abstract Microtubule plus end depolymerization rate is a potentially important target of physiological regulation, but it has been challenging to measure, so its role in spatial organization is poorly understood. Here we apply a method for tracking plus ends based on time difference imaging to measure depolymerization rates in large interphase asters growing in Xenopus egg extract. We observed strong spatial regulation of depolymerization rates, which were almost two-fold higher in the aster interior compared to the periphery, and much less regulation of polymerization or catastrophe rates. We interpret these data in terms of a limiting component model, where aster growth results in lower levels of soluble tubulin and MAPs in the interior cytosol compared to that at the periphery. The steady-state polymer fraction of tubulin was ∼30%, so tubulin is not strongly depleted in the aster interior. We propose that the limiting component for microtubule assembly is a MAP that inhibits depolymerization, and that egg asters are tuned to low microtubule density.
Evaluation and Optimization of Metabolome Sample Preparation Methods for Saccharomyces cerevisiae (2013)

Metabolome sampling is one of the most important factors that determine the quality of metabolomics data. The main steps in metabolite sample preparation include quenching and metabolite extraction. Quenching with 60% (v/v) cold methanol at -40 °C has been most commonly used for Saccharomyces cerevisiae, and this method was recently modified as "leakage-free cold methanol quenching" using pure methanol at -40 °C. Boiling ethanol (75%, v/v) and cold pure methanol are the most widely used extraction solvents for S. cerevisiae. In the present study, metabolome sampling protocols, including the above methods, were evaluated by analyzing 110 identified intracellular metabolites of S. cerevisiae using gas chromatography/time-of-flight mass spectrometry. According to our results, fast filtration followed by washing with an appropriate volume of water can minimize the metabolite loss due to cell leakage as well as the contamination by extracellular metabolites. For metabolite extraction, acetonitrile/water mixture (1:1, v/v) at -20 °C was the most effective. These results imply that the systematic evaluation of existing methods and the development of customized methods for each microorganism are critical for metabolome sample preparation to facilitate the reliable and accurate analysis of metabolome.
Using Sound to Divert Fish From Turbine Intakes (1991)

30-43
Large Temporal/Insular Cavernous Malformation Presenting with Headaches (2019)

Abstract: Cerebral cavernous malformations are often asymptomatic; however, acute symptoms may occur, suggesting a hemorrhagic episode. Surgical resection should be considered as the mainstay therapy among other treatment options when there is a symptomatic presentation. Particularly for those presenting without seizure, the decision to operate relies on a surgical approach that has acceptably low morbidity. Both the trans-temporal approach and the trans-sylvian trans-insular approach can be used for intra-axial lesions in the temporal–insular region. The trans-sylvian approach has been suggested to provide a short and straight trajectory to the surgical target and has been associated with a better postoperative outcome.
MG-132 Diagnostic utility of whole genome sequencing in paediatric medicine (2015)

<h3>Background</h3> Chromosome microarray analysis (CMA) is the current first-tier clinical investigation for paediatric patients with congenital malformations and/or neurodevelopmental disorders. Whole genome sequencing (WGS) promises to capture all classes of genetic variation in a single experiment, but the diagnostic yield of WGS compared to CMA in the clinical setting has not been established. <h3>Objectives</h3> The purpose of the study was to compare the diagnostic yield of WGS with CMA and other targeted sequence analysis. <h3>Methods</h3> Through the SickKids genome clinic 100 consecutive patients undergoing CMA were recruited and WGS was performed to compare diagnostic yield. <h3>Results</h3> WGS identified variants meeting clinical diagnostic criteria in 32% of cases, representing a 4-fold increase in diagnostic rate over CMA (8%) alone and &gt; 2-fold increase in CMA plus targeted sequence testing (15%). WGS identified all reportable rare CNVs that were detected by CMA. In an additional 27 patients, WGS revealed clinically significant SNV and indel mutations presenting in a dominant (72%) or a recessive (28%) manner. Four cases had variants in at least two genes involved in distinct genetic disorders, contributing to a more complex clinical phenotype. <h3>Conclusions</h3> Our data indicate that WGS is highly accurate and efficient, providing a diagnosis in 32% paediatric patients that meet clinical criteria for CMA. Clinical implementation of WGS as a single and primary molecular test will provide a higher diagnostic yield than conventional testing while decreasing the number of genetic tests and ultimately the time before reaching a genetic diagnosis.
Optical properties of surface micromachined mirrors with etch holes (1999)

We have investigated the optical properties of surface-micromachined polycrystalline silicon reflectors within the visible spectral range at five different wavelengths. The measurement results of the reflectivity of various microreflectors at four different incident angles (20/spl deg/, 30/spl deg/, 45/spl deg/, and 60/spl deg/) are presented. Optical properties of microreflectors realized using the multiuser MEMS process (MUMPS) have been investigated. Our studies have found that etch holes, widely used in the surface micromachining process to reduce the time for releasing structures by sacrificial undercutting, have a great influence on the optical properties of micromachined mirrors. Diffraction patterns created by two-dimensional etch-hole arrays on micromachined mirrors have been investigated. The diffraction by etch holes obeys the Fraunhofer diffraction theory when a collimated light source (e.g., a laser beam) is incident. We have shown that when the dimension of etch holes increases, an increasing portion of the incident power will be diffracted and transmitted due to etch holes, leading to decreasing reflectivity of surface micromachined mirrors.
Photoageing of Hair Fiber and Photoprotection (1994)

Examination by transmission electron microscopy of hair exposed to sunlight has revealed important damage. Findings indicate an alteration of various cell components. Damage occurs in the cuticle and leads to its loss. Separation of macrofibrils and destruction of melanin pigments result in cortex damage. Some of the chemical and physical changes which occur in hair exposed to sunlight were studied: formation of carbonyl groups, cystine destruction, modification of the proteins obtained by reduction of the disulfide bonds, losses in mechanical strength and discoloration are discussed. Effects of UV and visible radiations were studied. All of them cause modification in hair properties. Experiments with artificial light sources were carried out to reproduce these alterations. The role of water during exposure was studied. In particular, discoloration of brown hair is largely affected by it. We showed that Xenon lamps were useful to follow the photooxidation of hair and simulate natural alterations. The properties of some protective materials were examined.