gebhart/patrepeval huggingface dataset:
Robust Gesture Recognition Using Millimetric-Wave Radar System (2018)

Gesture recognition is one of the most intuitive forms of human-computer interface. Gesture sensing can replace interfaces such as touch and clicks needed for interacting with a device. In this article, we present a short-range compact 60-GHz mm-wave radar sensor that is sensitive to fine dynamic hand motions. A series of range-Doppler images are extracted and processed using a long recurrent all-convolution neural network for real-time dynamic hand gesture recognition. Furthermore, we make use of novel data augmentation techniques for the proposed gesture recognition system to generalize for multiple users and operating environments. The results show accurate classification performance requiring very low processor footprint facilitating implementation in embedded platforms with real-time user feedback.
Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid (2019)

Protoporphyrin IX-fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5-aminolevulinic acid. However, this approach has not been clinically established for breast cancer, probably due to insufficient delivery of 5-aminolevulinic acid to the mammary glands. In the present study, we directly exposed breast cancer cells to 5-aminolevulinic acid to assess their discrimination via protoporphyrin IX-fluorescence. Fluorescence intensity (FI) was measured in the human breast cancer cell lines MCF7 and MDA-MB-231 and breast epithelial cell line MCF10A by confocal microscopy and flow cytometry. After 5-aminolevulinic acid exposure for 2 hours, protoporphyrin IX-FI in MCF7 and MDA-MB-231 cells significantly increased with marked cell-to-cell variability, whereas that in MCF10A cells increased moderately. Combined exposure of the cancer cells to 5-aminolevulinic acid and Ko143, a specific inhibitor of ATP-binding cassette transporter G2, further increased protoporphyrin IX-FI and alleviated the cell-to-cell variability in MCF7 and MDA-MB-231 cells, indicating improvement in the reproducibility and accuracy for fluorescence-based cancer detection. The increased FI by combined administration of these two drugs was also demonstrated in cells obtained via fine needle aspiration from mouse xenograft models inoculated with MDA-MB-231 cells. Furthermore, a cutoff value for increased protoporphyrin IX-FI ratio, before and after exposure to these drugs, clearly discriminated between cancer and noncancer cells. Taken together, direct exposure to 5-aminolevulinic acid and Ko143 may be a promising strategy for efficient fluorescence-based detection of breast cancer cells ex vivo using fine needle aspiration.
4D Scalable Multi-View Video Coding Using Disparity Compensated View Filtering and Motion Compensated Temporal Filtering (2006)

In this paper, a novel framework for scalable multi-view video coding is described. A well known wavelet based scalable coding scheme for single-view video sequences has been adopted and extended to match the specific needs of scalable multi-view video coding. Motion compensated temporal filtering (MCTF) is applied to each video sequence of each camera. The use of a wavelet lifting structure guarantees perfect invertibility of this step, and as a consequence of its open-loop architecture, SNR and temporal scalability are attained. Correlations between the temporal subbands of adjacent cameras are reduced by a novel disparity compensated view filtering (DCVF), method which is also lifting based and open-loop to enable view scalability. Spatial scalability and entropy coding are achieved by the JPEG2000 spatial wavelet transform and EBCOT coding, respectively. Rate allocation along the temporal-view-filtered subbands is done by means of an RD-optimal algorithm. Experimental results show the high scaling capability in terms of SNR, temporal and view scalability
Structural modifications in the amino acid lysine induced by soft x-ray irradiation (1994)

The amino acid DL-lysine has been investigated using the surface-sensitive probe XPS (x-ray photoelectron spectroscopy). The XPS data confirm that solid-state lysine exists in the zwitterionic form. However, during the course of x-ray irradiation in the experiment, the molecule was observed to decompose. A decomposition mechanism consistent with the data has been proposed which involves transformation of the zwitterion to a free base, followed by decarboxylation, to produce 1,5-diaminopentane and CO2 gas. It would appear that caution should be exerted when studying amino acids using XPS if long x-ray irradiation times are employed.
An inflammatory subtype of pancreatic ductal adenocarcinoma is associated with poor prognosis and increased perioperative mortality (2019)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by an aggressive tumor behavior. The present analysis seeks to identify and analyze a cohort that meets criteria for “inflammatory” PDAC (IPDAC). All patients who underwent a curative resection for PDAC at our institution between 1989 and 2015 were included in the retrospective analysis. Patients with histological proven adenocarcinoma and elevated C-reactive protein (CRP) (≥6 mg/L) serum concentrations, but no other suspicion of infection were included. We provide a matched control group with normal CRP serum levels from the same patient cohort. Thirty-six (6.8%) of 532 patients meet our criteria for an IPDAC group type. In-hospital (30 days) mortality was 13.9% in the IPDAC group vs 0% in the control group ( P = .020). Median follow-up was 183.8 months (standard deviation [SD] = 53.3, range 14.3–285.4). Median overall survival was 8.5 months (SD = 16.8, range 0.3–89.6) in the IPDAC group and 24.8 months (SD = 19.4, range 0.7–80.4) in the control group ( P = .002). Patients indicating an IPDAC in our cohort had a significantly and clinical meaningful decreased overall survival and a higher perioperative morbidity and mortality.
Supplementary Figures 1 - 7 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma (2023)

&lt;p&gt;PDF file - 133K, Supplementary Figure 1. miRNA-21 is upregulated in HNSCC tumors. Supplementary Figure 2. RT-qPCR validation of miRNA-21 overexpression by transient transfection. (A) pre-miRNA-21 and (B) miRNA-21 expression level. Supplementary Figure 3. miRNA-21 overexpression stimulates cell proliferation. All measurements were obtained with the Cell Counting Kit -8 cell proliferation assay. ∗p&lt;0.01. Supplementary Figure 4. miRNA-21 loses specificity for CLU transcript when miRNA-21 binding seed sequence is deleted from the CLU 3'UTR sequence. ∗p&lt;0.03. Supplementary Figure 5. Relative expression of CLU-1 in normal and HNSCC cell lines. Supplementary Figure 6. RT-qPCR validation of CLU-1 overexpression by transient transfection. Supplementary Figure 7. CLU-1 has growth inhibitory effects in JHU-O28, FaDu and SCC9 HNSCC cell lines. Overexpression of CLU-1 inhibits cell proliferation. All measurements were obtained by taking direct cell counts at each time point. ∗p&lt;0.05.&lt;/p&gt;
Discrimination Among Multiple Cutaneous and Proprioceptive Hand Percepts Evoked by Nerve Stimulation with Utah Slanted Electrode Arrays in Human Amputees (2020)

Objective: This paper aims to demonstrate functional discriminability among restored hand sensations with different locations, qualities, and intensities that are evoked by microelectrode stimulation of residual afferent fibers in human amputees. Methods: We implanted a Utah Slanted Electrode Array (USEA) in the median and ulnar residual arm nerves of three transradial amputees and delivered stimulation via different electrodes and at different frequencies to produce various locations, qualities, and intensities of sensation on the missing hand. Blind discrimination trials were performed to determine how well subjects could discriminate among these restored sensations. Results: Subjects discriminated among restored sensory percepts with varying cutaneous and proprioceptive locations, qualities, and intensities in blind trials, including discrimination among up to 10 different location-intensity combinations (15/30 successes, p &lt; 0.0005). Variations in the site of stimulation within the nerve, via electrode selection, enabled discrimination among up to 5 locations and qualities (35/35 successes, p &lt; 0.0001). Variations in the stimulation frequency enabled discrimination among 4 different intensities at the same location (13/20 successes, p &lt; 0.005). One subject discriminated among simultaneous, alternating, and isolated stimulation of two different USEA electrodes, as may be desired during multi-sensor closed-loop prosthesis use (20/25 successes, p &lt; 0.001). Conclusion: USEA stimulation enables encoding of a diversity of functionally discriminable sensations with different locations, qualities, and intensities. Significance: These percepts provide a potentially rich source of sensory feedback that may enhance performance and embodiment during multi-sensor, closed-loop prosthesis use.
Multi-Physics Modeling for Electric and Hybrid Vehicles with In-Wheel Electric Motors (2018)

This paper discusses multi-domain and multi-physics modeling of in-wheel electric vehicles using ANSYS Simplorer and ANSYS Maxwell. The study includes component level modeling of the vehicle, brakes, wheels, battery, traction motor, inverter, solar panels and boost converter. The traction motor used is an axial flux permanent magnet synchronous machine. In order to accommodate both the large time constants of the mechanical system and the high switching frequency power electronics, average models of the inverter and boost converter are considered. Simulation examples are provided for the University of Kentucky Gato Del Sol V car.
Bone involvement in Hodgkin's disease (1982)

Eighteen patients with osseous involvement were identified from a series of 124 consecutive patients treated with combined-modality therapy with advanced-stage or relapsing Hodgkin's disease. Multiple lesions were seen as frequently as were solitary lesions. Nodular sclerosing histology was as prevalent as mixed cellularity disease. However, those five cases initially diagnosed at protocol entry were predominantly mixed cellularity (80%) with multiple lesions (80%). Sites of involvement included: the spine, 24; pelvis, 8; ribs, 4; femur, 3; skull, 1; and shoulder 1. Actuarial survival for these patients was 84% at nine years. Only three patients were induction failures and no patient has had a relapse. Patients with bone lesions had favorable responses to combined-modality therapy.
[Macular edema: Understand mechanisms to develop treatments]. (2020)

Macular edema is an increase in volume of the central area of the retina, responsible for visual acuity. Visual symptoms handicap the lives of millions of patients with macular edema secondary to chronic and sometimes acute retinal disease. Proteins that neutralize the vascular endothelial growth factor (VEGF) pathway or glucocorticoids, at the cost of repeated intraocular injections over years, limit visual symptoms. A better understanding of why and how edema forms and how therapeutic molecules exert an anti-edematous effect will help prevent this disabling and blinding retinal complication from occurring.
Ion Diffusion and Electrochemical Capacitance in Aligned and Packed Single-Walled Carbon Nanotubes (2010)

Direct measurement of ion diffusion in aligned, densified single-walled carbon nanotube electrodes showed that the diffusion coefficient for transport of ions (KSCN in acetonitrile) parallel to the alignment direction of the nanotubes was close to the theoretical limit of perfectly straight pores, achieving a value 20 times larger than that of activated carbon electrodes (1 × 10(-5) vs 5 × 10(-7) cm(2)/s). In contrast, the diffusion coefficient for ion transport perpendicular to the alignment direction was an order of magnitude smaller (8 × 10(-7) cm(2)/s). As an example of the ramifications of this anisotropic diffusion phenomenon, the difference in performance of the aligned carbon nanotubes as electrochemical-capacitor electrodes was evaluated. At low discharge rates, the performances of the two orientations were identical, but as the discharge rate was increased, a more rapid decline in capacitance was observed for the perpendicular orientation (66 vs 14% decline in capacitance when the discharge current was increased from 0.01 to 1 A/g). Furthermore, the maximum power rating of the perpendicular electrode was lower than that of the parallel electrode (1.85 vs 3 kW/kg during operation at 1 V).
Skeletal Muscle Is Anabolically Unresponsive to an Amino Acid Infusion in Pediatric Burn Patients 6 Months Postinjury (2011)

In pediatric burn patients at 6 months postinjury, leg muscle protein net deposition is unresponsive to amino acid infusion; and whole-body protein breakdown is significantly higher than in the control group.
De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor (1998)

On the basis of the structure-activity relationships of delta-opioid-selective peptide ligands and on a model of the proposed bioactive conformation for a potent and selective, conformationally constrained delta-opioid peptide ligand [(2S, 3R)-TMT1]DPDPE, a series of small organic peptide mimetic compounds targeted for the delta-opioid receptor have been designed, synthesized, and evaluated in radiolabeled ligand binding assays and in vitro bioassays. The new non-peptide ligands use piperazine as a template to present the most important pharmacophore groups, including phenol and phenyl groups and a hydrophobic moiety. This hydrophobic group was designed to mimic the hydrophobic character of the D-Pen residues in DPDPE, which has been found to be extremely important for increasing the binding affinity and selectivity of these non-peptide ligands for the delta-opioid receptor over the mu-opioid receptor. Compound 6f (SL-3111) showed 8 nM binding affinity and over 2000-fold selectivity for the delta-opioid receptor over the mu-opioid receptor. Both enantiomers of SL-3111 were separated, and the (-)-isomer was shown to be the compound with the highest affinity for the delta-opioid receptor found in our study (IC50 = 4.1 nM), with a selectivity very similar to that observed for the racemic compound. The phenol hydroxyl group of SL-3111 turned out to be essential to maintain high affinity for the delta-opioid receptor, which also was observed in the case of the delta-opioid-selective peptide ligand DPDPE. Binding studies of SL-3111 and [p-ClPhe4]DPDPE on the cloned wild-type and mutated human delta-opioid receptors suggested that the new non-peptide ligand has a binding profile similar to that of DPDPE but different from that of (+)-4-[((alphaR)-alpha(2S,5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC-80), another delta-opioid-selective non-peptide ligand.
Maintaining Enterprise Resiliency via Kaleidoscopic Adaption and Transformation of Software Services (MEERKATS) (2016)

Abstract : We have designed, implemented, evaluated, and in some cases deployed a set of new technologies that add continuous change, deception, and unpredictability to cloud environments as a way to increase their resilience to a broad spectrum of threats. Our work makes significant advances along five major directions: (1) continuous migration technologies that can enable for the first time the swift migration of cloud-resident services and data either in response to an attack or continuously so as to present a moving-target defense; (2) cloud information flow tracking technologies that can track cloud-resident data at larger scales than ever before; (3) misinformation and decoy technologies that can automatically generate deceptive information - bogus information that appears genuine - so as to confuse, bait, and track attackers; (4) cloud monitoring and self-healing technologies that integrate information from many sensors to detect complex, multi-stage attacks; (5) stable multithreading technologies that reduce the security risks posed by concurrent programs by ensuring that programs take only a few pre-checked, safe schedules during execution; and (6) hardware-enhanced execution memoization techniques that enable efficient execution in highly replicated environments.
Impact of interleukin-10 on phenotype and gene expression during early monocyte differentiation into dendritic cells. (2013)

IL-10 inhibits DC function and redirects differentiation of DCs to cells with a different phenotype, thereby reducing the pool of potential DC precursors.
JoBimText Visualizer: A Graph-based Approach to Contextualizing Distributional Similarity (2013)

We introduce an interactive visualization component for the JoBimText project.JoBim-Text is an open source platform for large-scale distributional semantics based on graph representations.First we describe the underlying technology for computing a distributional thesaurus on words using bipartite graphs of words and context features, and contextualizing the list of semantically similar words towards a given sentential context using graphbased ranking.Then we demonstrate the capabilities of this contextualized text expansion technology in an interactive visualization.The visualization can be used as a semantic parser providing contextualized expansions of words in text as well as disambiguation to word senses induced by graph clustering, and is provided as an open source tool.
Adsorption of metal ions on crosslinked poly(4‐vinylpyridine) resins prepared with a metal ion as template (1977)

Abstract Poly(4‐vinylpyridine) (PVP) was crosslinked with 1,4‐dibromobutane with a metal ion as template. The adsorption behavior of copper, cobalt, zinc, and cadmium ions on the obtained resin (DBQP) was studied. The DBQP resin prepared with a metal ion as template preferentially adsorbed the metal ion used as template. The stability constant of the copper complex of DBQP was largest for the DBQP resin prepared with a copper ion as template, which was due to its large entropy change for the complexation.
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity (2017)

Tumor escape to immunosurveillance and resistance to immune attacks present a major hurdle in cancer therapy, especially in the current era of new cancer immunotherapies. We report here that hypoxia, a hallmark of most solid tumors, orchestrates carcinoma cell heterogeneity through the induction of phenotypic diversity and the acquisition of distinct epithelial-mesenchymal transition (EMT) states. Using lung adenocarcinoma cells derived from a non-metastatic patient, we demonstrated that hypoxic stress induced phenotypic diversity along the EMT spectrum, with induction of EMT transcription factors (EMT-TFs) SNAI1, SNAI2, TWIST1, and ZEB2 in a hypoxia-inducible factor-1α (HIF1A)-dependent or -independent manner. Analysis of hypoxia-exposed tumor subclones, with pronounced epithelial or mesenchymal phenotypes, revealed that mesenchymal subclones exhibited an increased propensity to resist cytotoxic T lymphocytes (CTL), and natural killer (NK) cell-mediated lysis by a mechanism involving defective immune synapse signaling. Additionally, targeting EMT-TFs, or inhibition of TGF-β signaling, attenuated mesenchymal subclone susceptibility to immune attack. Together, these findings uncover hypoxia-induced EMT and heterogeneity as a novel driving escape mechanism to lymphocyte-mediated cytotoxicity, with the potential to provide new therapeutic opportunities for cancer patients.
Inline Cryogenic Temperature Sensor Based on the Excitation of Localized Plasmonic Oscillations in Metallic Nanoparticles Embedded into Photonic Crystal Fibers (2007)

We describe the operation of an inline temperature sensor based on the inclusion of metallic nanoparticles into a photonic crystal fiber. A robust sensing platform for spectroscopy and optical switching applications can be designed.
Inhibitory Effect of Interferon on Cellular DNA Synthesis: Modulation by Pure mitogenic Factors (1981)

Quiescent Swiss 3T3 cells can be stimulated to synthesize DNA by combinations of polypeptide hormones, retinoids and tubulin-disrupting agents. Low doses of mouse interferon are effective in inhibiting DNA synthesis induced by one, two or three factors. When more growth factors are added DNA synthesis is not further stimulated, although the dose response curve for interferon is shifted dramatically to the right. Even when added before the mitogenic stimulus, up to 2000 units of interferon have no effect on DNA synthesis stimulated by five factors. A change in the dose-response curve for interferon as an antiviral agent is also observed when the mitogenic stimulation is increased, but the effect is less dramatic than that observed on its function as an inhibitor of DNA synthesis.
Catalytic Enantioselective Synthesis of Highly Functionalized Difluoromethylated Cyclopropanes (2017)

Abstract The first catalytic asymmetric synthesis of highly functionalized difluoromethylated cyclopropanes is described. The method, based on a rhodium‐catalyzed cyclopropanation of difluoromethylated olefins, gives access to a broad range of cyclopropanes bearing ester, ketone, or nitro functional groups. By using Rh 2 (( S )‐BTPCP) 4 as a catalyst, the corresponding products were obtained in high yields and high diastereo‐ and enantioselectivities (up 20:1 d.r. and 99 % ee ). This methodology allowed preparation of enantioenriched difluoromethylcyclopropanes for the first time.
Detection of the linalool‐producing NES1 variant across diverse strawberry (Fragaria spp.) accessions (2012)

With 4 figures and 3 tables Abstract Many volatile compounds have been shown to influence the flavour of strawberry ( Fragaria spp.) fruit. A published study demonstrated that linalool, a critical flavour compound, is produced in cultivated F. × ananassa varieties owing to a truncated form of the NEROLIDOL SYNTHASE (NES) enzyme. The corresponding allele ( FaNES1 ) features a 5′‐deletion that is detectable by PCR. Herein, we tested a broad set of strawberry genotypes to understand the origin of the allele and to identify materials that may be preferred candidates for molecular breeding. The results indicate that the FaNES1 allele (linalool+) is not present in any diploid, tetraploid or hexaploid accession tested. It is present in 112 F. × ananassa cultivars examined. The FaNES1 allele is present in all but three of 46 wild F. virginiana and F. chiloensis genotypes. Two of these three lines continue to produce linalool despite the absence of the allele. This survey suggests that the FaNES1 allele possibly arose following octoploidization and that linalool possibly is an important factor in strawberry biology, aside from its role in anthrocentric fruit quality attributes.
Photoactivated Localization Microscopy (PALM) of Adhesion Complexes (2008)

Key to understanding a protein's biological function is the accurate determination of its spatial distribution inside a cell. Although fluorescent protein markers allow the targeting of specific proteins with molecular precision, much of this information is lost when the resultant fusion proteins are imaged with conventional, diffraction-limited optics. In response, several imaging modalities that are capable of resolution below the diffraction limit (∼200 nm) have emerged. Here, both single- and dual-color superresolution imaging of biological structures using photoactivated localization microscopy (PALM) are described. The examples discussed focus on adhesion complexes: dense, protein-filled assemblies that form at the interface between cells and their substrata. A particular emphasis is placed on the instrumentation and photoactivatable fluorescent protein (PA-FP) tags necessary to achieve PALM images at ∼20 nm resolution in 5 to 30 min in fixed cells.