gebhart/patrepeval huggingface dataset:
Lasing Emission from Plasmonic Nanodome Arrays (2016)

We demonstrate a new feedback mechanism to achieve nano-lasing using plasmonic nano-dome array (PNDA) substrates. The unique off-normal lasing phenomenon in the PNDA lasers provides useful applications which cannot be implemented by other plasmonic lasers.
ChemInform Abstract: 3D Framework Structure of a New Lithium Thiophosphate, LiTi2(PS4)3, as Lithium Insertion Hosts. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SYNTHESIS OF (+, -) ZOAPATANOL: SYNTHESIS OF IONOPHORE ANTIBIOTIC X-14547A, COUPLING OF RIGHT AND LEFT WINGS, TRANS BUTADIENE FORMATION, AND 2-KETOPYRROLE FORMATION. N-PHENYLSELENO PHTHALIMIDE (N-PSP) AND N-PHENYLSELENO SUCCINIMIDE (N-PSS), TWO VERSATILE CARRIERS OF THE PHENYLSELENO GROUP (1982)

The total synthesis of ((+OR-)) zoapatanol a novel oxepane diterpene having contragestational properties originally isolated from zoapatanol leaves (Montanoa Tomentosa) by Levine and co-workers of Ortho Pharmaceuticals has been completed in a stereoselective manner. This synthesis allows for significant quantities of pure synthetic ((+OR-)) zoapatanol for biological screening as a mixture of inseparable diastereomers due to the (alpha)-methyl of a carbonyl. The total synthesis of Ionophore Antibiotic X-14547A, discovered by Westley of Hoffman LaRoche, has been accomplished in a enantioselective manner. This thesis describes the coupling of the two key fragments, the stereospecific formation of the trans-butadiene system, and the introduction of the ketopyrrole system. From this synthesis, two novel derivatives of X-14547A have also been prepared. The biological significance of X-14547A stems from its antibiotic, antitumor, and ruminent feed improvement activity. Two novel carriers of the Phenylseleno N-Phenylselenophthalimide (N-PSP) and N-Phenylselenosuccinimide (N-PSS) have been explored for use as reagents in organic synthesis. The preparation of N-PSP is described by a simple and high yield procedure from phenylselenylchloride and potassiumphthalimide. The reactions of N-PSP and N-PSS with olefins containing internal and external nucleophiles to form cyclic substrates and (beta)-hydroxy Phenylselenides respectively is demonstrated. The synthesis of cyclic diphenylseleno ethers from dienes and phenylselenomacrolactones from long chain olefinic acids is detailed using N-PSP or N-PSS. The combination of N-PSP and tributylphosphine for the synthesis of alkyl phenylselenides from alcohols and phenylselenol esters from acids is shown in a high yield process. These reagents are suitable candidates for transformations involved in natural products synthesis since the phenylseleno group can be removed via oxidative elimination or reductive cleavage.
Lien entre la toxicité, la contamination des milieux aquatiques mesurés chez Gammarus fossarum et la perturbation des communautés biologiques : Proposition de valeurs seuils au niveau national pour la mesure de marqueurs de toxicité chez Gammarus fossarum. (2019)

Caging of controlled and calibrated gammarids is now recognized as a relevant approach for contamination and toxicity assessment of freshwater aquatic systems. Molecular markers or life traits are available in this species and are proposed as toxicity markers for aquatic monitoring and for which threshold values have been recently proposed throughout a local study (Rhône-Alpes). Based on a national study with more than eighty stations, the present study focuses on the development and the proposal of threshold values for three markers, acetylcholinesterase activity, feeding rate and the fertility and their comparison with those previously available at regional scale. Results show that regional and national threshold values are similar. Finally, and for each toxicity marker, a graduated scale was developed and proposed in order to specify and define the level of observed effects. This new graduated scale makes it possible to interpret measurements in terms of severity, in regard to the distribution of effects observed in this national study.
SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury (2018)

Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases. PTOA leads to reduced physical activity, deconditioning of the musculoskeletal system, and in severe cases requires joint replacement to restore function. Therefore, treatments that would prevent cartilage degradation post-injury would provide attractive alternatives to surgery. Sclerostin (Sost), a Wnt antagonist and a potent negative regulator of bone formation, has recently been implicated in regulating chondrocyte function in OA. To determine whether elevated levels of Sost play a protective role in PTOA, we examined the progression of OA using a noninvasive tibial compression overload model in SOST transgenic (SOST<sup>TG</sup> ) and knockout (Sost<sup>-/-</sup> ) mice. Here we report that SOST<sup>TG</sup> mice develop moderate OA and display significantly less advanced PTOA phenotype at 16 weeks post-injury compared with wild-type (WT) controls and Sost<sup>-/-</sup> . In addition, SOST<sup>TG</sup> built ∼50% and ∼65% less osteophyte volume than WT and Sost<sup>-/-</sup> , respectively. Quantification of metalloproteinase (MMP) activity showed that SOST<sup>TG</sup> had ∼2-fold less MMP activation than WT or Sost<sup>-/-</sup> , and this was supported by a significant reduction in MMP2/3 protein levels, suggesting that elevated levels of SOST inhibit the activity of proteolytic enzymes known to degrade articular cartilage matrix. Furthermore, intra-articular administration of recombinant Sost protein, immediately post-injury, also significantly decreased MMP activity levels relative to PBS-treated controls, and Sost activation in response to injury was TNFα and NF-κB dependent. These results provide in vivo evidence that sclerostin functions as a protective molecule immediately after joint injury to prevent cartilage degradation. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
JEC 61850 - A Practical Application Primer for Protection Engineers (2006)

This paper reviews concepts proposed by the IEC 61850 standard; protection and control (P&C) aspect in particular. The standard describes building blocks meant to facilitate the general idea of migrating traditionally hard-wired P&C connections and configurations into the realm of software, while opening considerable opportunities for engineering and labor savings. The underlying principle is that the newly introduced complexity resides in software, and therefore, new software tools will reduce or eliminate some of it, simplifying both the engineering and deployment, thus resulting in a substantial net gain. IEC 61850 has received considerable attention in recent years, but vast majority of publications are written around the theme of the intelligent electronic device (IED), and rest at introducing the concept, reviewing selected details of IED implementations, and focusing on anticipated advantages. This paper is written for a traditional P&C engineer and reviews important practical questions that need to be answered, solutions worked out, and tools developed before the IEC 61850 concept could see its all-inclusive implementation
Laparoscopic Nephrectomy: Initial Case Report (2016)

A tumor-bearing right kidney was completely excised from an 85-year-old woman using a laparoscopic approach. A newly devised method for intra-abdominal organ entrapment and a recently developed laparoscopic tissue morcellator made it possible to deliver the 190 gm. kidney through an 11 mm. incision.
Optical frequency metrology and its contribution to the determination of fundamental constants (2001)

Optical frequency metrology plays an important role for the determination of the Rydberg constant and offers an alternative way to determine the fine structure constant α. We have developed a new technique for measuring optical frequencies using femtosecond light pulses culminating in the single laser optical frequency synthesizer. This new technique greatly simplifies the task of measuring optical frequencies.
Complement Activation in Sudden Deafness (1998)

The elevated levels of C3bc in patients with sudden deafness indicate an activation of the first part of the complement cascade and therefore suspected inflammatory causes. Measurements of C3bc levels might identify patients with sudden deafness who would benefit from treatment with anti-inflammatory drugs.
Exploring Information-Theoretic Criteria to Accelerate the Tuning of Neuromorphic Level-Crossing ADCs (2023)

Level-crossing analog-to-digital converters (LC-ADCs) are neuromorphic, event-driven data converters that are gaining much attention for resource-constrained applications where intelligent sensing must be provided at the extreme edge, with tight energy and area budgets. LC-ADCs translate real-world analog signals (such as ECG, EEG, etc.) into sparse spiking signals, providing significant data bandwidth reduction and inducing savings of up to two orders of magnitude in area and energy consumption at the system level compared to the use of conventional ADCs. In addition, the spiking nature of LC-ADCs make their use a natural choice for ultra-low-power, event-driven spiking neural networks (SNNs). Still, the compressed nature of LC-ADC spiking signals can jeopardize the performance of downstream tasks such as signal classification accuracy, which is highly sensitive to the LC-ADC tuning parameters. In this paper, we explore the use of popular information criteria found in model selection theory for the tuning of the LC-ADC parameters. We experimentally demonstrate that information metrics such as the Bayesian, Akaike and corrected Akaike criteria can be used to tune the LC-ADC parameters in order to maximize downstream SNN classification accuracy. We conduct our experiments using both full-resolution weights and 4-bit quantized SNNs, on two different bio-signal classification tasks. We believe that our findings can accelerate the tuning of LC-ADC parameters without resorting to computationally-expensive grid searches that require many SNN training passes.
Revisiting the Paxos Foundations (2017)

research-article Share on Revisiting the Paxos Foundations: A Look at Summer Internship Work at VMware Research Authors: Heidi Howard University of Cambridge, and VMware OCTO University of Cambridge, and VMware OCTOView Profile , Dahlia Malkhi VMware OCTO VMware OCTOView Profile , Sasha Spiegelman Technion, Israel, and VMware OCTO Technion, Israel, and VMware OCTOView Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 51Issue 1August 2017 pp 67–71https://doi.org/10.1145/3139645.3139656Published:11 September 2017Publication History 0citation248DownloadsMetricsTotal Citations0Total Downloads248Last 12 Months12Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Structural insight into the stereoselective production of PGF2α by Old Yellow Enzyme from Trypanosoma cruzi (2011)

Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2α) by TcOYE.
The impact of new technologies on clinical decision-making in health care (2015)

Decision-making in the clinic has been revolutionized by high-throughput technologies for genomic/transcriptomic sequencing and proteome/metabolome analysis. Close collaborations between academia and health care have driven the implementation of frontline technologies and bioinformatics in clinical diagnostics. As a result, clinicians are able to make faster and better-informed assessments of a patient’s condition, allowing treatment to be personalized for maximum efficacy. These advances have also provided new opportunities to understand disease mechanisms and develop novel treatment strategies. In this webinar, our expert panel will demonstrate how both diagnosis and treatment can be improved and lives saved using next-generation genomic profiling and functional analyses.
Post-Silicon Validation and Calibration of Hardware Security Primitives (2014)

Physical Unclonable Functions (PUFs) and True Random Number Generators (TRNGs) are gaining significant importance in the field of hardware security. These crypto-graphic primitives harness randomness from IC fabrication process and on-chip noise respectively, necessitating unconventional post-Silicon (Si) validation techniques. In this work, we present a brief survey of post-Si validation techniques for PUFs and TRNGs, highlighting the importance of testing PUFs resilience against novel attacks and monitoring bias in TRNGs. We also propose novel techniques for monitoring PUFs reliability and measuring bias in TRNGs. The proposed techniques do not only facilitate on-chip calibration for hardware security systems, but can also be used as a countermeasure against fault-attacks.
Executing Dynamic Data-Graph Computations Deterministically Using Chromatic Scheduling (2022)

A data-graph computation -popularized by such programming systems as Galois, Pregel, GraphLab, PowerGraph, and GraphChi -is an algorithm that performs local updates on the vertices of a graph. During each round of a data-graph computation, an update function atomically modifies the data associated with a vertex as a function of the vertex's prior data and that of adjacent vertices. A dynamic data-graph computation updates only an active subset of the vertices during a round, and those updates determine the set of active vertices for the next round.
Carbon-hydrogen bond activating reactions of thoracyclobutanes. Routes to unusual actinide-transition metal .mu.-methylene complexes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-hydrogen bond activating reactions of thoracyclobutanes. Routes to unusual actinide-transition metal .mu.-methylene complexesGregory M. Smith, Michal Sabat, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1987, 109, 6, 1854–1856Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ja00240a042https://doi.org/10.1021/ja00240a042research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hybrid model predictive control of active suspension with travel limits and nonlinear tire contact force (2016)

Optimal control techniques have been widely applied to the control of active suspensions. However, most of these applications did not consider the nonlinear effects existing in real suspension systems. In this paper, a constrained nonlinear quarter-car active suspension is simplified and modeled as a piecewise affine (PWA) system where the suspension elements may collide with bump stops or the tire may leave the ground. A hybrid MPC controller is first designed based on this model. The PWA system is then augmented in order to capture the previewed road information to further improve the performance. The resulting hybrid MPC controller is compared to a linear MPC design and a LQ-based controller in simulation. The hybrid MPC designs are shown to achieve better performances in terms of ride and road handling qualities over a large road disturbance.
Athermal laser design (2014)

This paper discusses circuit based and waveguide based athermalization schemes and provides some design examples of athermalized lasers utilizing fully integrated athermal components as an alternative to power hungry thermo-electric controllers (TECs), off-chip wavelength lockers or monitors with lookup tables for tunable lasers. This class of solutions is important for uncooled transmitters on silicon.
Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins (2018)

A-kinase anchoring proteins (AKAPs) shape second-messenger signaling responses by constraining protein kinase A (PKA) at precise intracellular locations. A defining feature of AKAPs is a helical region that binds to regulatory subunits (RII) of PKA. Mining patient-derived databases has identified 42 nonsynonymous SNPs in the PKA-anchoring helices of five AKAPs. Solid-phase RII binding assays confirmed that 21 of these amino acid substitutions disrupt PKA anchoring. The most deleterious side-chain modifications are situated toward C-termini of AKAP helices. More extensive analysis was conducted on a valine-to-methionine variant in the PKA-anchoring helix of AKAP18. Molecular modeling indicates that additional density provided by methionine at position 282 in the AKAP18γ isoform deflects the pitch of the helical anchoring surface outward by 6.6°. Fluorescence polarization measurements show that this subtle topological change reduces RII-binding affinity 8.8-fold and impairs cAMP responsive potentiation of L-type Ca<sup>2+</sup> currents in situ. Live-cell imaging of AKAP18γ V282M-GFP adducts led to the unexpected discovery that loss of PKA anchoring promotes nuclear accumulation of this polymorphic variant. Targeting proceeds via a mechanism whereby association with the PKA holoenzyme masks a polybasic nuclear localization signal on the anchoring protein. This led to the discovery of AKAP18ε: an exclusively nuclear isoform that lacks a PKA-anchoring helix. Enzyme-mediated proximity-proteomics reveal that compartment-selective variants of AKAP18 associate with distinct binding partners. Thus, naturally occurring PKA-anchoring-defective AKAP variants not only perturb dissemination of local second-messenger responses, but also may influence the intracellular distribution of certain AKAP18 isoforms.
Liquid Crystals with Polar Substituents Containing Fluorine: Synthesis and Physical Properties (1991)

Abstract Liquid crystalline compounds with various polar terminal groups containing fluorine have been prepared (see below formula 1 with Z = S‒CHF2, S‒CF3, SO‒CHF2, SO‒CF3, SO2‒CHF2, SO2‒CF3, SO2F, OCH2CF3, CO‒OCH2CF3, CO‒CF3, CO‒CF2Cl, CO‒CF2H, CO‒CF2‒CH3, CO‒CF2‒C3H7). The synthesis of these compounds is outlined here and their physical properties (phase transitions, dielectric anisotropy, birefringence, viscosity) are discussed.
Direct observations of Neel lines propagation in ferrimagnetic garnet epilayers with canted magnetization (1988)

The net displacements of Neel lines belonging to unwinding or winding line pairs, resulting from the application of pulsed direct or gyrotropic forces, is investigated. It is found that pairs, whether winding or unwinding, shrink faster than they expand under the action of direct forces; under the action of gyrotropic forces, winding pairs exhibit a peculiar behavior; and a static field parallel to the easy axis has a considerable influence on line displacements, especially under the action of gyrotropic forces. Samples utilized in the present study are thick (TbY)/sub 3/(FeAl)/sub 5/O/sub 12/ garnet epilayers grown on
ChemInform Abstract: Stereochemistry of the Methyl→Methylene Elimination in the Enzyme‐Catalyzed Cyclization of Geranyl Diphosphate to (4S)‐Limonene. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Short and Efficient Synthesis of (3S,4S)‐4‐((tert‐Butyloxycarbonyl)amino)‐5‐cyclohexyl‐3‐hydroxypentanoic Acid Ethyl Ester. (1988)

Abstract The phenylalanine (I) is hydrogenated and then N‐protected to yield the cyclohexylalanine derivative (IV) which is coupled with the Mg enolate of the malonic acid half ester (V), producing the β‐keto ester (VI).
A NODE ENRICHMENT STRATEGY IN COLLOCATED DISCRETE LEAST SQUARES MESHLESS METHOD FOR THE SOLUTION OF GENERALIZED NEWTONIAN FLUIDS FLOW (2014)

A simple node enrichment strategy using a gradient based error estimator is presented for the Collocated Discrete Least Squares (CDLS) meshless method. Also, a procedure is defined to distribute collocation points according tothefield nodes position. Here, shape functions are constructed using Radial Point Interpolation Method (RPIM). As temporal discretization a first-order accurate scheme, named semi-incremental fractional step method is used. One of the advantages of this scheme is its capability to use large time step sizes for the solution of the governing equations on steady state problems. The capability of the presented strategy is shown by investigating Carreau-Yasuda fluid flow model in solving lid-driven cavity flow problemwith different curve fitting indices values.
Room temperature vacuum sealing using surfaced activated bonding with au thin films (2005)

We report surface activated bonding (SAB) using Au thin films with a thickness of a few tens of nanometers which can be applied to room temperature vacuum sealing for microelectromechanical systems (MEMS) packaging. In a previous study, it was found that room temperature bonding of Si/Si and Si/chemical mechanical polished (CMP) electroplated Cu could be successfully applied to vacuum sealing of micro cavities. However this method needs high vacuum in bonding process for keeping activated surfaces and the surfaces should be cleaned by wet processes. In this study, we attempt to realize room temperature vacuum sealing in low vacuum without any wet surface pre-treatments utilizing Au thin films with controlled surface roughness. We propose and develop packaging structures with comb-drive resonators for characterization of sealing quality and show the applicability of SAB of Au-Au thin films to vacuum-seal packaging.