gebhart/patrepeval huggingface dataset:
Hybrid Quantum-Classical Approach to Correlated Materials (2015)

Recent improvements in control of quantum systems make it seem feasible to finally build a quantum computer within a decade. While it has been shown that such a quantum computer can in principle solve certain small electronic structure problems and idealized model Hamiltonians, the highly relevant problem of directly solving a complex correlated material appears to require a prohibitive amount of resources. Here, we show that by using a hybrid quantum-classical algorithm that incorporates the power of a small quantum computer into a framework of classical embedding algorithms, the electronic structure of complex correlated materials can be efficiently tackled using a quantum computer. In our approach, the quantum computer solves a small effective quantum impurity problem that is self-consistently determined via a feedback loop between the quantum and classical computation. Use of a quantum computer enables much larger and more accurate simulations than with any known classical algorithm, and will allow many open questions in quantum materials to be resolved once a small quantum computer with around one hundred logical qubits becomes available.
Abiotic Sequence‐Coded Oligomers as Efficient In Vivo Taggants for the Identification of Implanted Materials (2018)

Abstract Sequence‐defined oligourethanes were tested as in vivo taggants for implant identification. The oligomers were prepared in an orthogonal solid‐phase iterative approach and thus contained a coded monomer sequence that can be unequivocally identified by tandem mass spectrometry (MS/MS). The oligomers were then included in small amounts (1 wt %) in square‐centimeter‐sized crosslinked poly(vinyl alcohol) (PVA) model films, which were intramuscularly and subcutaneously implanted in the abdomen of rats. After one week, one month, or three months of implantation, the PVA films were explanted. The rat tissues exposed to the implants did not exhibit any adverse reactions, which suggested that the taggants are not harmful and probably not leaching out from the films. Furthermore, the explanted films were immersed in methanol, as a solvent for oligourethanes, and the liquid extract was analyzed by mass spectrometry. In all cases, the oligourethane taggant was detected, and its sequence was identified by MS/MS.
Structure‐Based Evolution of Subtype‐Selective Neurotensin Receptor Ligands (2014)

Subtype-selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of μ-opioid-independent anti-nociceptive effects. Based on the crystal structure of the subtype NTS1 and previous structure-activity relationships (SARs) indicating a potential role for the sub-pocket around Tyr11 of NT(8-13) in subtype-specific ligand recognition, we have developed new NTS2-selective ligands. Starting from NT(8-13), we replaced the tyrosine unit by β(2)-amino acids (type 1), by heterocyclic tyrosine bioisosteres (type 2) and peptoid analogues (type 3). We were able to evolve an asymmetric synthesis of a 5-substituted azaindolylalanine and its application as a bioisostere of tyrosine capable of enhancing NTS2 selectivity. The S-configured test compound 2 a, [(S)-3-(pyrazolo[1,5-a]pyridine-5-yl)-propionyl(11)]NT(8-13), exhibits substantial NTS2 affinity (4.8 nm) and has a nearly 30-fold NTS2 selectivity over NTS1. The (R)-epimer 2 b showed lower NTS2 affinity but more than 600-fold selectivity over NTS1.
Continuous Particle Cross Over in Microfluidic Channels for Continuous Biosensing (2006)

A novel concept for continuous biosensing is introduced. Continuous biosensing is achieved by the mechanism named "Particle Cross Over" within microfluidic channels. The functionality of the device is demonstrated by quantifying the binding events of biotin to streptavidin coated beads. The device is designed to have precisely controlled flow structures which allow cytometric beads to pass from one flow region to another without mixing the carrier and sample fluids. The mean and standard deviation of the cytometric bead pixel intensities are 43.52 and 19.39, respectively for 1 μg/ml of biotinylated Fluorescein IsoThioCyanate concentration with a binding time of 0.464 seconds and shows a Gaussian distribution. It is expected that the particle cross over mechanism introduced in this report will be very useful mechanism for applications in continuous biosensing.
Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation (2016)

A new synthetic route to human relaxin-2 has been established through a sequential disulfide bond formation process in the absence of iodine. It is enabled by a combination of cysteine protection with penicillin G acylase-labile Phacm and a newly identified thiol activator bis(5-(2-methoxyethoxy)-2-pyrimidinyl disulfide. The long-standing challenges in relaxin B-chain assembly and its poor solubility have been solved by the insertion of two isoacyl dipeptide segments. The overall yield was 25% from the B chain and 5.8% from the B-chain starting resin.
The Design and Development of a Non-Contact Printer for Product Coding (1988)

This paper is concerned with the design and development of a low-cost system for applying product information to a target area on the top of a carton passing through a cartoning machine at, typically, 60 cartons a minute. A prototype was designed and built which prints high-quality preprogrammed characters on to a range of carton sizes, can be adjusted in the x, y and z planes and can be fitted to a variety of existing packaging machines.
Memristor SPICE model and crossbar simulation based on devices with nanosecond switching time (2013)

This paper presents a memristor SPICE model that is able to reproduce current-voltage relationships of previously published memristor devices. This SPICE model shows a stronger correlation to various published device data when compared to existing SPICE models. Furthermore, switching characteristics of published memristor devices with switching times in the nanosecond scale were modeled. Therefore, this model can be used to accurately simulate neural systems based on these high-speed memristors. This paper also demonstrates how this model can be used to accurately calculate switching energy of these high-speed devices, leading to more accurate power calculations in memristor based neural systems. Memristor crossbar circuits provide a potential method for developing very high density neural classifiers. This model was able to simulate crossbar circuits containing up to 256 memristors. It is significantly less likely to cause convergence errors when operating in the nanosecond switching regime with a large number of devices when compared with existing SPICE models.
Radiation in the management of pancreatic neuroendocrine tumors. (2012)

335 Background: Radiation therapy (RT) has not historically been incorporated into multidisciplinary management of pancreatic neuroendocrine tumors (PNTs). We provide a two-institution series of patients with PNTs who were treated with external beam RT either neoadjuvantly to attempt down-staging for surgery, or in the setting of post-surgical recurrence. Our objective was to assess treatment response and outcomes in this cohort of patients. Methods: We identified eleven patients with a pathologic diagnosis of PNT from 2006-2011 who received external beam RT to the primary tumor or resection bed. Each institution’s electronic medical record was used to evaluate patient demographics, disease characteristics, treatment regimens and tolerance, radiographic response, and survival. Results: Our series consists of eleven patients (6 men, 5 women) with a mean age of 57 years (range 37-72 years). All had biopsy proven PNT and were clinically T3 (n=3) or T4 (n=8), M0. Five patients were clinically node positive. All patients received RT to the primary tumor or resection bed to a median dose of 50.4 Gy. Seven patients received concurrent chemotherapy with capecitabine at a median dose of 1000mg/m 2 bid. Nine patients were treated definitively for locally advanced disease, two of whom subsequently underwent surgical resection. Two patients were treated to palliate post-resection recurrence. Initial radiographic response to RT included 2 complete responses (CR), 2 partial responses (PR), 4 stable disease, 3 progressive disease (PD). Two patients were classified as PD due to the development of distant metastases less than 2 months after completing RT. Two grade 3 toxicities were documented (one early, one late). At a median follow-up of 30.4 months, three patients had died with evidence of PD, two had died without evidence of PD, three were alive with metastases, and three were alive without evidence of disease progression (1 stable, 1 PR, 1 CR). From the start of RT, median overall survival was 32.1 months; progression free survival was 14.6 months. Conclusions: RT may have the potential to convert PNTs from locally-advanced to resectable. RT may also increase local control of PNTs. Consideration should be given to the use of RT in prospective trials of PNT treatment.
Induction of Apoptosis by Bee Venom in A549 Human Lung Epithelial Cancer Cells through Modulation of Bcl-2 and IAP Family and Activation of Caspases (2007)

본 연구에서 봉독의 apoptosis 유도에 의한 항암기전 효능을 A549 인체폐암세포를 대상으로 조사하였으며, apoptosis 유발에 관여할 것으로 예상되는 중요한 유전자들의 발현 및 활성에 미치는 봉독의 영향을 조사하였다. A549 세포의 생존율은 봉독의 처리 농도 증가에 따라 강력하게 억제되었으며, 이는 염색질 응축 현상을 동반한 apoptosis 유발에 의한 것임을 알 수 있었다. 봉독 처리에 의한 apoptosis 유발은 Bax 및 Bcl-xL의 발현 변화 없이 Bcl-2의 발현 감소에 따른 상대적인 Bax의 발현 증가와 IAP family에 속하는 인자들의 발현 감소 및 caspase의 활성화와 연관성이 있었다. Bee venom is used to treat inflammatory diseases in Korean traditional medicine and has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in bee venom-induced apoptosis are still uncharacterized in human lung cancer cells. In the present study, we investigated the effects of bee venom on the apoptosis of A549 human lung epithelial cancer cells. Treatment of bee venom inhibited the cell viability and induced apoptosis in a concentration-dependent manner as measured by hemocytometer counts, fluorescence microscopy and flow cytometry analysis. Bee venom-induced apoptosis in A549 cells was associated with a marked inhibition of anti-apoptotic Bcl-2 expression without significant changes in the levels of Bax and Bcl-xL. Bee venom treatment also inhibited the levels of IAP family members such as cIAP-1 and cIAP-2 and induced the proteolytic activation of caspase-3 and caspase-9. Although further studies are needed, the present results suggest that apoptotic signals evoked by bee vemon in A549 cancer cells may converge caspases activation through a down-regulation of Bcl-2 rather than an up-regulation of Bax. These findings provide important insights into the possible molecular mechanisms of the anti-cancer activity of bee vemon in human cancer cells.
Quadtree structures and improved techniques for motion representation and entropy coding in HEVC (2012)

Recently, the first milestone in the development of the High Efficiency Video Coding standard (HEVC) was reached by issuing the Committee Draft of the standard. In order to satisfy the growing need for higher coding efficiency than H.264/AVC as state-of-the-art video codec, the HEVC project was initiated by the ITU-T VCEG and the ISO/IEC MPEG jointly issuing a call for proposals on video compression technology. The key techniques of the Fraunhofer HHI response to the call such as a quadtree-based block structure for prediction and transform coding as well as improved prediction and transform coding methods have been incorporated into the HEVC design. In this paper, these techniques are revisited, their current implementation in HEVC is described and results showing the impact thereof are presented.
P-selectin mediates spontaneous leukocyte rolling in vivo (1993)

Rolling represents the initial step leading to leukocyte extravasation from blood vessels during an inflammatory reaction. In vitro studies indicate that P-selectin could be one of the ligands on endothelium involved in the rolling phenomenon, although the molecular determinants responsible for this transient attachment in vivo are still undefined. Our objectives were to develop a blocking monoclonal antibody against canine P-selectin and to use it to investigate the role of P-selectin in leukocyte rolling in vivo using the technique of intravital microscopy. P-selectin was immunoaffinity purified from canine platelets and used for the production of monoclonal antibodies. One of the hybridomas generated, MD6, was shown by enzyme-linked immunosorbent assay and by flow cytometry to bind preferentially to stimulated platelets and to completely prevent binding of stimulated platelets to neutrophils. Visualization of canine mesenteric venules by intravital microscopy showed that administration of MD6 resulted in a marked inhibition in the number of rolling leukocytes (18.96 +/- 9.92 v 156.40 +/- 19.50 leukocytes/min, P < .05; 88.3% +/- 6.0% inhibition). Control antibody MD3 (which recognizes a nonfunctional epitope of canine P-selectin) had no effect on the number of rolling leukocytes or on their rolling velocity. These results show for the first time that P-selectin plays an essential role in leukocyte rolling in vivo, and therefore may be a key participant of the inflammatory response.
Correction: Corrigendum: Robust Type-specific Hemisynapses Induced by Artificial Dendrites (2016)

Scientific Reports 6: Article number: 24210; published online: 13 April 2016; updated: 20 June 2016 In the original version of this Article, an additional affiliation for Taek Dong Chung was omitted. The correct affiliation is listed below: Advanced Institutes of Convergence Technology, Suwon-Si, Gyeonggi-do 16229, Korea.
Dynamic surface roughness profiler (2012)

A dynamic profiler is presented that is capable of precision measurement of surface roughness in the presence of significant vibration or motion. Utilizing a special CCD camera incorporating a micro-polarizer array and a proprietary LED source, quantitative measurements were obtained with exposure times of &lt;100 &mu;sec. The polarization-based interferometer utilizes an adjustable input polarization state to optimize fringe contrast and signal to noise for measurement of optical surfaces ranging in reflectivity from 1 to 100%. A new phase calculation algorithm is presented that nearly eliminates phase-dependent errors resulting in shot noise limited performance. In addition to its vibration immunity, the system’s light weight, &lt;5 kg, compact envelope, 24 x 24 x 8 cm, integrated alignment system, and multiple mounting options facilitate use both directly resting on large optical surfaces and directly mounted to polishing equipment, stands, gantries and robots. Measurement results presented show an RMS repeatability &lt;0.005 nm and an RMS precision &lt; 0.1nm which are achieved without active vibration isolation.
Synthese und Struktur von ITQ‐3, dem ersten reinen Silicatpolymorph mit einem zweidimensionalen System aus geraden Achterring‐Kanälen (1997)

Hydrothermalsynthesn in fluoridhaltigen Medien führen leicht zu Materialien mit sehr niedrigen Gerüstdichten, wie die Synthese von ITQ‐3 beispielhaft zeigt. ITQ‐3 ist ein Silicatpolymorph der Formel [SiO 2 ] 64 , das ein Gerüst mit einer sehr niedrigen Dichte (16.3 SiO 4 ‐Tetraeder pro 1000 A 3 ) und großem Mikroporenvolumen (0.23 cm 3 g −1 ) sowie einem zweidimensionalen System gerader Kanäle aufweist, deren Kreuzungspunkte große Käfige (Bild rechts) definieren. magnified image
Synthesis and characterization of the mononuclear compounds tert-Bu2MOAr (M = aluminum or gallium, Ar = bulky aryl group): are the short Al-O and Ga-O bonds a consequence of .pi.-interactions? (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of the mononuclear compounds tert-Bu2MOAr (M = aluminum or gallium, Ar = bulky aryl group): are the short Al-O and Ga-O bonds a consequence of .pi.-interactions?Mark A. Petrie, Marilyn M. Olmstead, and Philip P. PowerCite this: J. Am. Chem. Soc. 1991, 113, 23, 8704–8708Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00023a018https://doi.org/10.1021/ja00023a018research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Nonlinear filtering in coherent optical systems through halftone screen processes (1975)

Nonlinear filtering operations can be performed in coherent optical systems with the help of the halftone screen process. Theoretical and practical considerations regarding this type of system are presented. The use of these methods to achieve logarithmic filtering is emphasized. Applications to separation of multiplicative signals and noise, speckle noise reduction, and processing of radiographic images are considered. Experimental results are presented.
Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells (2009)

The effect of anthrax infection on phosphoprotein signaling was studied in human small airway lung epithelial cells exposed to B. anthracis spores of the plasmidless dSterne strain in comparison with the Sterne strain containing the toxigenic plasmid (pXO1). The differential regulation of phosphorylation was found in the mitogen-activated protein kinase cascade (ERK, p38, and P90RSK), the PI3K cascade (AKT, GSK-3alpha/beta), and downstream in the case of the proapoptotic BAD and the transcription factor STAT3. Both strains stimulate phosphorylation of CREB and inhibit phosphorylation of 4E-BP1 required for activation of cap-dependent translation. Downregulation of the survival AKT phosphorylation by the Sterne strain inhibits the process of Ca(2+)-dependent homophilic interaction of E-cadherin (EC) upon formation or repair of cell-cell contacts. Both lethal and edema toxins produced by the Sterne strain inhibit the AKT phosphorylation induced during the EC-mediated signaling. Activity of ERK1/2 and p38 inhibitors indicates that inhibition of AKT phosphorylation takes place through the ERK1/2-PI3K crosstalk. In Sterne spore-challenged mice, a specific inhibitor of PI3K/AKT, wortmannin, accelerates the lethal outcome, and reduction of AKT phosphorylation in the circulating blood cells coincides with the death of animals. We conclude that the PI3K/AKT pathway controlling the integrity of epithelium plays an important survival role in anthrax infection.
Vestibular Electrical Evoked Potential (VEEP) Findings in Normal Controls and in Patients with Vestibular Dysfunction (P02.251) (2012)

Objective: To report results of human VEEP studies in normal controls compared to patients with peripheral or central vestibular dysfunction. Background The VEEP has been described in animal models (cat and guinea pig) and more recently in humans. In contrast to other evoked potentials, a unique linear relationship between current strength and latency has been reported with VEEP responses in normal individuals. Design/Methods: Normal control subjects (n=5) and patients with vestibular dysfunction (n=3) were studied with electrical stimulation over the mastoid in one mA increments from threshold to no higher than 20 mA. Evoked potentials were recorded with standard signal averaging techniques. Results: In normal controls, mastoid stimulation at 2.5mA yielded Cz-A1/2 VEEP responses of median latency 10.2ms (range 6.0-13.3; SD 4.9). These responses progressively increased in latency from 8.6 to 22.6ms (mean latency increase of 1.3ms/mA) as current strength was increased in 10 steps (1mA/step) from threshold. VEEP responses differed significantly in stimulation threshold, morphology, amplitude and latency from mastoid dermatomal somatosensory evoked potentials (SEPs), great auricular sensory nerve action potentials (SNAPs), and frontalis compound muscle action potentials (CMAPs). Neither acoustic stimuli nor white noise masking affected the VEEP. In 3 patients with vestibular dysfunction (one each with acoustic neuroma, Meniere disease and multiple sclerosis as the cause) VEEP late response latencies were absent or markedly asymmetric, with recordable responses showing a median latency of 12.2ms (range 11.2-12.7; SD 0.4); none demonstrated the linear increasing current strength-latency pattern seen in normals. Conclusions: 1) VEEP studies produced reproducible responses in normal controls; 2) VEEP responses cannot be attributed to auditory or somatic sensory nerve responses; 3) VEEP current strength-latency curves showed a linear increase in normals in contrast to absent, flat, and/or decreasing patterns in patients with vestibular dysfunction. Supported by: Mayo Foundation. Disclosure: Dr. Smith has nothing to disclose. Dr. Cevette has nothing to disclose. Dr. Stepanek has nothing to disclose. Dr. Cocco has nothing to disclose. Dr. Pradhan has nothing to disclose. Dr. Brookler has nothing to disclose. Dr. Zapala has nothing to disclose. Dr. Ross has nothing to disclose.
Towards a shared care model for stable diabetic retinopathy patients: a feasibility trial in Singapore (2017)

Purpose While diabetic retinopathy ( DR ) is a chronic disease, patients in Asian’ health care systems are often managed within hospital settings. Aim of this feasibility study is to assess the quality of care and economic benefits of a shared care model managing patients with stable DR in a primary eye care clinic ( PEC ) compared with a current tertiary specialist outpatient clinic ( SOC ) in Singapore. Methods A randomized equivalence feasibility trial was performed, to compare a PEC with a SOC . The trial patients included those previously seen at the SOC , and having no DR or stable mild non proliferative ( NPDR ) with no macular edema, no visual and DR deterioration. Primary outcomes were clinical management. Secondary outcomes were patient satisfaction and cost of consultation. Differences analysis used equivalence testing and generalized odds ratios ( GOR ). Results The trial included 231 patients, 83.1% classified as no DR ( PEC : 79.1%; SOC : 87.1%) and 16.9% as stable mild NPDR ( PEC : 20.9%; SOC : 12.9%). DR management at PEC was significantly equivalent to that received at the SOC (rate difference 2.56%; CI :(−1.61% to 6. 74%)) and 4.29%; CI : (0.14%–8.45%), respectively. Patient satisfaction at the PEC was high when compared to SOC ( GOR : 1.71; CI : (0.50–2.00)). Direct costs per patient visit were 45% lower at PEC compared to SOC . Conclusions Our feasibility trial showed that patients with no or stable DR receive similar clinical care and management at a lower‐cost PEC setting, are equally satisfied with the service compared to tertiary eye care. A follow‐up study is necessary to validate these findings. Managing stable DR patients at a PEC may be a safe and effective shared care model to improve accessibility for patients while enhancing professional collaboration between hospital and community settings.