gebhart/patrepeval huggingface dataset:
Design, Manufacturing and Testing of a New Family of Steam Turbine Low Pressure Stages (2007)

New low pressure (LP), stages for variable speed, mechanical drive and geared power generation steam turbines have been developed. The new blade and nozzle designs can be applied to a wide range of turbine rotational speeds and last stage blade annulus areas, thus forming a family of low pressure stages—High Speed (HS) blades and nozzles. Different family members are exact scales of each other and the tip speeds of the corresponding blades within the family are identical. Thus the aeromechanical and aerodynamic characteristics of the individual stages within the family are identical as well. Last stage blades and nozzles have been developed concurrently with the three upstream stages, creating optimised, reusable low pressure turbine sections. These blades represent a step forward in improving speed, mass flow capability, reliability and aerodynamic efficiency of the low pressure stages for the industrial steam turbines. These four stages are designed as a system using the most modern design tools applied on Power Generation and Aircraft Engines turbo-machineries. The aerodynamic performance of the last three stage of the newly designed group will be verified in a full-scale test facility. The last stage blade construction incorporates a three hooks, axial entry dovetail with improved load carrying capability over other blade attachment methods. The next to the last stage blade also uses a three hooks axial entry dovetail, while the two front stage blades employ internal tangential entry dovetails. The last and next to the last stage blades utilize continuous tip coupling via implementation of integral snubber cover while a Z-lock integral cover is employed for the two upstream stages. Low dynamic strains at all operating conditions (off and on resonance speeds) will be validated via steam turbine testing at realistic steam conditions (steam flows, temperatures and pressures). Low load, high condenser pressure operation will also be verified using a three stage test turbine operated in the actual steam conditions as well. In addition, resonance speed margins of the four stages have been verified through full-scale wheel box tests in the vacuum spin cell, thus allowing the application of these stages to Power Generation applications. Stator blades are produced with a manufacturing technology, which combines full milling and electro-discharge machining. This process allows machining of the blades from an integral disc, and thus improving uniformity of the throat distribution. Accuracy of the throat distribution is also improved when compared to the assembled or welded stator blade technology. This paper will discuss the aerodynamic and aeromechanical design, development and testing program completed for this new low pressure stages family.
Erratum to: Higgs boson production cross-section measurements and their EFT interpretation in the $$4\ell $$ decay channel at $$\sqrt{s}=$$13 TeV with the ATLAS detector (2021)

In the published HTML version of this article, the affiliations of the authors of the National Research Nuclear University MEPhI, Moscow, Russia were unfortunately marked incorrectly.
Light Modulation by Applying High Electric Fields in Double-Insulated ZnS and ZnSe Polycrystalline Films (1990)

Absorption-edge shifts produced by applying electric fields (Franz-Keldysh) in ZnS and ZnSe polycrystalline films have been studied for investigating their application to spatial light modulators. The ZnS and ZnSe polycrystalline films are sandwiched between the insulating layers so that high electric fields of up to about 10 6 V/cm can be applied to the films. As a result, the adsorption edge is shifted by about 3 nm toward longer wavelength and a light modulation degree of 45% is obtained.
Supplementary Figure 5 from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study (2023)

&lt;p&gt;ER DNA methylation in hormone-resistant tumor biopsies.&lt;/p&gt;
Impact of Biomedical Optics and Planning our Revised Scope (2020)

Journal of Biomedical Optics editor-in-chief Brian W. Pogue outlines a revision of scope for the journal.
Adenosine Promotes Tumor Metastasis (2013)

An early step in tumor metastasis is a reduction in cell-cell adhesion to enable cell scattering. Contacts between cells are stabilized by accumulation in the plasma membrane of the small guanosine triphosphatase (GTPase) Rap1B. The membrane localization of Rap1B is increased when it is posttranslationally modified by prenylation of its C-terminal Cys-Ala-Ala-X motif. A new study shows that Rap1B prenylation and plasma membrane localization were reduced when Rap1B was phosphorylated by protein kinase A (PKA). In some tumors, high adenosine production and an abundance of G(s)-coupled adenosine A(2B) receptors would be expected to cause persistent PKA signaling and reduced Rap1B prenylation. These findings suggest that adenosine signaling reduces prenylation and plasma membrane localization of Rap1B, resulting in enhanced tumor cell scattering and invasiveness.
Ultrafast electronic structures and dynamics of CdSe nanocrystals revealed by gas phase time-resolved photoelectron spectroscopy (2014)

Using time-resolved photoelectron spectroscopy in a gas phase environment, we observed the evanescent electron wavefunction of quantum dot excited states, and the effect of solvent on QD charge transfer.
Inhibition of Human Cytomegalovirus DNA Polymerase by C-Terminal Peptides from the UL54 Subunit (2003)

In common with other herpesviruses, the human cytomegalovirus (HCMV) DNA polymerase contains a catalytic subunit (Pol or UL54) and an accessory protein (UL44) that is thought to increase the processivity of the enzyme. The observation that antisense inhibition of UL44 synthesis in HCMV-infected cells strongly inhibits viral DNA replication, together with the structural similarity predicted for the herpesvirus processivity subunits, highlights the importance of the accessory protein for virus growth and raises the possibility that the UL54/UL44 interaction might be a valid target for antiviral drugs. To investigate this possibility, overlapping peptides spanning residues 1161 to 1242 of UL54 were synthesized and tested for inhibition of the interaction between purified UL54 and UL44 proteins. A peptide, LPRRLHLEPAFLPYSVKAHECC, corresponding to residues 1221 to 1242 at the very C terminus of UL54, disrupted both the physical interaction between the two proteins and specifically inhibited the stimulation of UL54 by UL44. A mutant peptide lacking the two carboxy-terminal cysteines was markedly less inhibitory, suggesting a role for these residues in the UL54/UL44 interaction. Circular dichroism spectroscopy indicated that the UL54 C-terminal peptide can adopt a partially alpha-helical structure. Taken together, these results indicate that the two subunits of HCMV DNA polymerase most likely interact in a way which is analogous to that of the two subunits of herpes simplex virus DNA polymerase, even though there is no sequence homology in the binding site, and suggest that the UL54 peptide, or derivatives thereof, could form the basis for developing a new class of anti-HCMV inhibitors that act by disrupting the UL54/UL44 interaction.
Patterns of Diabetes Care Among People with Type 1 Diabetes During Ramadan: An International Prospective Study (DAR-MENA T1DM) (2020)

The DAR-MENA study showed that despite the risks associated with fasting for people with type 1 diabetes, almost half fasted for the full 30 days of Ramadan with no significant change in hypoglycemia events. Since the current International Diabetes Federation and Diabetes and Ramadan guidelines do not endorse fasting for people with type 1 diabetes, it is important that those who insist on fasting work closely with their healthcare practitioner to avoid any complications.
Kazuistika oroglandulární formy tularémie s překvapivým kultivačním záchytem nokardií ve zkolikvované uzlině (2006)

Prace popisuje kazuistiku oroglandularni formy tularemie se soucasným zachytem Nocardia sp. v punktatu z uzliny. Shrnuje klinický průběh, problemy se stanovenim etiologickeho agens (serologický průkaz tularemie a kultivacni zachyt nokardii). Zmiňuje terapii kombinaci doxycyklinu se streptomycinem a nasledně cotrimoxazolem. Diskutuje otazku vzniku onemocněni a zvažuje soucasnou ci sekundarni infekci nokardiemi.
La patrimonialisation de la Préhistoire à l’épreuve des faits : Denis Peyrony et l’affaire du Roc du Barbeau (1934-1949) (2022)

En 1934, Maurice Vidal met au jour un squelette mésolithique dans le gisement du Roc du Barbeau (Tursac, Dordogne). Importante sur le plan anthropologique, cette découverte présente un autre intérêt majeur. Il est en effet possible de suivre, de son invention à son entrée au Musée de Préhistoire des Eyzies, le devenir de ce squelette, à l’origine d’un imbroglio qui occupe le propriétaire du terrain, l’inventeur du squelette, nombre de savants – dont l’Inspecteur des Monuments préhistoriques Denis Peyrony – et l’Administration des Beaux-Arts entre 1934 et 1949. Grâce à une riche documentation primaire pour l’essentiel inédite, cet essai de microhistoire se propose d’étudier sur une période de quinze ans les pratiques préhistoriennes dans le domaine des fouilles proprement dites puis dans celui de la conservation et de la patrimonialisation des vestiges qui en sont issus. Le choix délibérement fait de nous placer aux côtés des protagonistes de l'affaire et de les suivre pas à pas autorise l’appréhension d’éléments qui restent généralement inaccessibles à d’autres échelles, permettant ainsi de mesurer de manière assez précise le rôle de chacun d’eux dans son déroulement. Placé au centre de l’étude, l’individu redevient ce qu’il a réellement toujours été au cours de sa vie : un acteur de son histoire et de l’Histoire.
Improving speech translation with automatic boundary prediction (2007)

This paper investigates the influence of automatic sentence boundary and sub-sentence punctuation prediction on machine translation (MT) of automatically recognized speech.We use prosodic and lexical cues to determine sentence boundaries, and successfully combine two complementary approaches to sentence boundary prediction.We also introduce a new feature for segmentation prediction that directly considers the assumptions of the phrase translation model.In addition, we show how automatically predicted commas can be used to constrain reordering in MT search.We evaluate the presented methods using a state-of-the-art phrase-based statistical MT system on two large vocabulary tasks.We find that careful optimization of the segmentation parameters directly for translation quality improves the translation results in comparison to independent optimization for segmentation quality of the predicted source language sentence boundaries.
Evaluation of the fusion partner cell line SPYMEG for obtaining human monoclonal antibodies against influenza B virus (2018)

Influenza B virus has been known to infect humans and other animals, including seals. Vaccination efficacy varies across seasons. Human monoclonal antibodies (mAbs) can be useful for developing novel vaccines, guided by epitope analysis, and can be used therapeutically. Hybridoma technology has been used to make mAbs. Here we evaluated SPYMEG as a fusion partner cell line for human mAb generation specific to influenza B hemagglutinin (HA). SPYMEG is a human/murine myeloma partner cell line that has previously been used to generate human mAbs that recognize the HA of influenza A and B viruses. Peripheral blood mononuclear cells were obtained from 16 volunteers, previously vaccinated with the 2014-2015 trivalent seasonal influenza vaccine, and were fused with SPYMEG to yield hybridomas. The resulting hybridomas were screened for antigen-specific antibody secretion and cloned by limiting dilution. We obtained 32 stable clones secreting anti-influenza B HA human IgG, although most of these clones were obtained from one volunteer (SeaV-29) who had a robust immune response. We conclude that SPYMEG is a good fusion partner cell line, although cloning by limiting dilution may lead to significant loss of hybridomas.
Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids (2020)

Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly understood. A major challenge for investigating HCMV-induced abnormal brain development is the strict CMV species specificity, which prevents the use of animal models to directly study brain defects caused by HCMV. We show that infection of human-induced pluripotent-stem-cell-derived brain organoids by a "clinical-like" HCMV strain results in reduced brain organoid growth, impaired formation of cortical layers, and abnormal calcium signaling and neural network activity. Moreover, we show that the impeded brain organoid development caused by HCMV can be prevented by neutralizing antibodies (NAbs) that recognize the HCMV pentamer complex. These results demonstrate in a three-dimensional cellular biosystem that HCMV can impair the development and function of the human brain and provide insights into the potential capacity of NAbs to mitigate brain defects resulted from HCMV infection.
SU‐DD‐A3‐05: Evaluation of Respiration‐Correlated Digital Tomosynthesis for Soft Tissue Visualization (2006)

Purpose: To find optimal parameters for digital tomosynthesis (DTS) image acquisition, assess DTS imaging for soft tissue visualization and patient positioning, and determine if DTS can be acquired fast enough to avoid blur caused by the respiratory motion Methods and Materials: We have used Varian gantry‐mounted kV on‐board imaging system to acquire DTS images as well as reference cone‐beam CT (CBCT) scans. An external respiratory monitor system recorded patient respiration together with the x‐ray on/off signal during imaging for retrospective sorting of projections based on respiration phase. DTS reconstruction used backprojection followed by a deblur. For a lung tumor subject to the respiratory motion we also reconstructed DTS images during a short time interval (∼ 1 s = 6° arc at 1 rpm) around the end‐exhalation. Results: Phantom studies indicate that image quality increases with DTS arc length; however, longer arc lengths cause image blur and degradation. Optimal DTS arc length is 10–20.° Patient studies also indicate that at approximately 15° arc length image quality, as judged visually, is the best. For longer arcs image blur increases, while for shorter arcs out of plane objects become more pronounced. For all arc lengths tumor visualization was possible. Both manual and automatic 2D registrations of DTS and CBCT were possible in most cases. For short (6°) or long (30°) arc lengths manual registration became more challenging and automatic registration less precise, but still possible. Registration of a respiratory correlated DTS image over a 6,° non‐optimal arc, was possible. Conclusions: DTS is capable of soft tissue and bone visualization and can be an efficient imaging modality for image‐guided radiotherapy. DTS can be acquired, with some tradeoff in image quality, during a ∼1s time interval, allowing reduction of respiratory motion artefacts. Conflict of interest: Research sponsored by NCI Grant P01‐CA59017 and Varian Medical Systems.
Preparation of (001)-oriented Pb(Zr,Ti)O/sub 3/ thin films and their piezoelectric applications (2007)

Preparation of (001)-oriented Pb(Zr,Ti)O(3) (PZT) thin films and their applications to a sensor and actuators were investigated. These thin films, which have a composition close to the morphotropic phase boundary, were epitaxially grown on (100)MgO single-crystal substrates by RF magnetron sputtering. These (001)-oriented PZT thin films could be obtained on various kinds of substrates, such as glass and Si, by introducing (100)-oriented MgO buffer layers. In addition, the (001) oriented PZT thin films could be obtained on Si substrates without buffer layers by optimizing the sputtering conditions. All of these thin films showed excellent piezoelectric properties without the need for poling treatment. The PZT thin films on the MgO substrates had a high piezoelectric coefficient, d(31), of -100 pm/V, and an extremely low relative dielectric constant, epsilon(r), of 240. The PZT thin films on Si substrate had a very high d(31) of -150 pm/V and an epsilon(r) = 700. These PZT thin films were applied to an angular rate sensor with a tuning fork in a car navigation system, to a dual-stage actuator for positioning the magnetic head of a high-density hard disk drive, and to an actuator for an inkjet printer head for industrial on-demand printers.
Reducing the Impact of Data Sparsity in Statistical Machine Translation (2014)

Morphologically rich languages generally require large amounts of parallel data to adequately estimate parameters in a statistical Machine Translation(SMT) system. However, it is time consuming and expensive to create large collections of parallel data. In this paper, we explore two strategies for circumventing sparsity caused by lack of large parallel corpora. First, we explore the use of distributed representations in an Recurrent Neural Network based language model with different morphological features and second, we explore the use of lexical resources such as WordNet to overcome sparsity of content words.
Editorial (1991)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
ChemInform Abstract: Improved Synthesis of D,L‐Fluorocitric Acid. (2011)

Abstract A decagram synthesis of D,L‐fluorocitric acid (VI) is presented.
Full bridge circuit based on pentacene schottky diodes fabricated on plastic substrates (2012)

In this work, we demonstrate a full bridge diode (FBD) circuit compatible and fabricated on flexible polyethylene naphthalene (PEN) substrate. The fabrication was carried out using photolithography-based processes and pentacene Schottky diodes as the active circuit components. The individual pentacene diodes show the on/off current ratio of 105, with reverse and forward bias current densities of 10−4 and 102 A cm−2, respectively. Diodes and the full bridge configuration were measured in the range of −10 to +10 V. Discrete diodes fabricated in the same substrate show similar behavior to those integrated in the FBD circuit. The frequency response was evaluated using an ac signal and voltage ranging from 1 to 5 MHz and −10 to +10V, respectively. The dc output voltage under these conditions was 7–8.5 V for individual diodes and 3–5.5 V for the FBD circuit. The resulting FBD circuits show full wave rectification for ac signals up to ±10 V in the frequency regime tested. The circuit demonstrated could be used for ac-related energy harvesting requiring rectification. One of such energy harvesting approaches could be power generated from micro-cantilevers.
A mutant phosphoenolpyruvate carboxykinase in Escherichia coli conferring oxaloacetate decarboxylase activity (1995)

The phosphoenolpyruvate carboxykinase in Escherichia coli (encoded by pck) catalyzes the conversion from oxaloacetate (OAA) to phosphoenolpyruvate under gluconeogenic conditions. We report here the characterization of two mutant alleles, pck-51 and pck-53, both of which are point mutations leading to single amino acid changes (D to N at position 268 and G to S at position 284, respectively). Pck51 is an altered-activity mutant that catalyzes the conversion from OAA to pyruvate (OAA decarboxylase activity). This new activity was not detected from the wild-type Pck, and it complements the pck null mutation only in a pps+ background. Pck53 is a reduced-activity mutant that complements the pck null mutation in a strain-dependent fashion.
Energy-Aware Load Balancing in Content Delivery Networks (2011)

Internet-scale distributed systems such as content delivery networks (CDNs) operate hundreds of thousands of servers deployed in thousands of data center locations around the globe. Since the energy costs of operating such a large IT infrastructure are a significant fraction of the total operating costs, we argue for redesigning CDNs to incorporate energy optimizations as a first-order principle. We propose techniques to turn off CDN servers during periods of low load while seeking to balance three key design goals: maximize energy reduction, minimize the impact on client-perceived service availability (SLAs), and limit the frequency of on-off server transitions to reduce wear-and-tear and its impact on hardware reliability. We propose an optimal offline algorithm and an online algorithm to extract energy savings both at the level of local load balancing within a data center and global load balancing across data centers. We evaluate our algorithms using real production workload traces from a large commercial CDN. Our results show that it is possible to reduce the energy consumption of a CDN by more than 55% while ensuring a high level of availability that meets customer SLA requirements and incurring an average of one on-off transition per server per day. Further, we show that keeping even 10% of the servers as hot spares helps absorb load spikes due to global flash crowds with little impact on availability SLAs. Finally, we show that redistributing load across proximal data centers can enhance service availability significantly, but has only a modest impact on energy savings.
Optical polarization effect in discrete time fiber-optic structures for microwave signal processing (2002)

We report the effect of the optical polarization in discrete time fiber-optic devices for microwave signal processing applications. Experimental results show that even in the incoherent working regime of these devices, the polarization state of the optical carrier can strongly affect the overall microwave response. A new analysis based on the optical S-matrix representation is developed in order to model correctly these devices. It is found that the optical polarization can be exploited efficiently for tuning the microwave response.
Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates (2017)

Proper chromosome alignment and segregation during mitosis depend on cohesion between sister chromatids, mediated by the cohesin protein complex, which also plays crucial roles in diverse genome maintenance pathways. Current models attribute DNA binding by cohesin to entrapment of dsDNA by the cohesin ring subunits (SMC1, SMC3, and RAD21 in humans). However, the biophysical properties and activities of the fourth core cohesin subunit SA2 (STAG2) are largely unknown. Here, using single-molecule atomic force and fluorescence microscopy imaging as well as fluorescence anisotropy measurements, we established that SA2 binds to both dsDNA and ssDNA, albeit with a higher binding affinity for ssDNA. We observed that SA2 can switch between the 1D diffusing (search) mode on dsDNA and stable binding (recognition) mode at ssDNA gaps. Although SA2 does not specifically bind to centromeric or telomeric sequences, it does recognize DNA structures often associated with DNA replication and double-strand break repair, such as a double-stranded end, single-stranded overhang, flap, fork, and ssDNA gap. SA2 loss leads to a defect in homologous recombination-mediated DNA double-strand break repair. These results suggest that SA2 functions at intermediate DNA structures during DNA transactions in genome maintenance pathways. These findings have important implications for understanding the function of cohesin in these pathways.