gebhart/patrepeval huggingface dataset:
Novel 5,6-dihydropyrazolo-[3,4-E][1,4]diazepin-4 (1H)-one derivatives for the treatment of asthma and chronic obstructive pulmonary disease (2007)

This application claims dihydropyrazolodiazepinones as phospho-diesterase 4(PDE4) inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. The compounds are shown to be potent inhibitors of PDE4B2, but no other biological data are provided. Thus, it is not clear whether these compounds provide any advantage over previously described PDE4 inhibitors or whether the issues frequently associated with PDE4 inhibitors have been addressed.
Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass (2022)

The human acellular vessel (HAV) was evaluated for surgical bypass in a phase II study. The primary results at 24 months after implantation have been reported, and the patients will be evaluated for ≤10 years. In the present report, we have described the 6-year results of a prospective, open-label, single-treatment arm, multicenter study. Patients with advanced peripheral artery disease (PAD) requiring above-the-knee femoropopliteal bypass surgery without available autologous graft options had undergone implantation with the HAV, a bioengineered human tissue replacement blood vessel. The patients who completed the 24-month primary portion of the study will be evaluated for ≤10 years after implantation. The present mid-term analysis was performed at the 6-year milestone (72 months) for patients followed up for 24 to 72 months. HAVs were implanted in 20 patients at three sites in Poland. Seven patients had discontinued the study before completing the 2-year portion of the study: four after graft occlusion had occurred and three who had died of causes deemed unrelated to the conduit, with the HAV reported as functional at their last visit. The primary results at 24 months showed primary, primary assisted, and secondary patency rates of 58%, 58%, and 74%, respectively. One vessel had developed a pseudoaneurysm deemed possibly iatrogenic; no other signs of structural failure were reported. No rejections or infections of the HAV occurred, and no patient had required amputation of the implanted limb. Of the 20 patients, 13 had completed the primary portion of the study; however, 1 patient had died shortly after 24 months. Of the remaining 12 patients, 3 died of causes unrelated to the HAV. One patient had required thrombectomy twice, with secondary patency achieved. No other interventions were recorded between 24 and 72 months. At 72 months, five patients had a patent HAV, including four patients with primary patency. For the entire study population from day 1 to month 72, the overall primary, primary assisted, and secondary patency rate estimated using Kaplan-Meier analysis was 44%, 45%, and 60% respectively, with censoring for death. No patient had experienced rejection or infection of the HAV, and no patient had required amputation of the implanted limb. The infection-resistant, off-the-shelf HAV could provide a durable alternative conduit in the arterial circuit setting to restore the lower extremity blood supply in patients with PAD, with remodeling into the recipient’s own vessel over time. The HAV is currently being evaluated in seven clinical trials to treat PAD, vascular trauma, and as a hemodialysis access conduit.
A skeletal framework artificial hand actuated by small sized pneumatic artificial muscles (2000)

This paper describes a method and a process for developing a soft artificial hand similar to a real human hand, which is actuated by the soft actuator, called "Mckibben pneumatic artificial muscle". The pneumatic artificial muscle makes an artificial hand not only move softly and powerfully by pneumatic power but also work as a sensor. Applying pneumatic artificial muscles, the hand becomes very soft in material as well as motion and reacts sensitively to the load for its self-sensing function in the actuator.
Three-part differential of unlabeled leukocytes with a compact lens-free imaging flow cytometer (2014)

A compelling clinical need exists for inexpensive, portable haematology analyzers that can be utilized at the point-of-care in emergency settings or in resource-limited settings. Development of a label-free, microfluidic blood analysis platform is the first step towards such a miniaturized, cost-effective system. Here we assemble a compact lens-free in-line holographic microscope and employ it to image blood cells flowing in a microfluidic chip, using a high-speed camera and stroboscopic illumination. Numerical reconstruction of the captured holograms allows classification of unlabeled leukocytes into three main subtypes: lymphocytes, monocytes and granulocytes. A scale-space recognition analysis to evaluate cellular size and internal complexity is also developed and used to build a 3-part leukocyte differential. The lens-free image-based classification is compared to the 3-part white blood cell differential generated by using a conventional analyzer on the same blood sample and is found to be in good agreement with it.
On the Design of a Radio Numerology for 5G Wide Area (2015)

A 5th Generation (5G) radio access technology is expected to cope with the relentless increase of the data traffic demand and is meant to accommodate a plethora of services with different requirements. In this paper, we elaborate on the design of the radio numerology for a 5G wide area system operating at carrier frequencies below 6 GHz. The main requirements are identified, and their inevitable conflicts are addressed. The proposed numerology options enable low latency with tolerable overhead, while maintaining a common clock with the Long Term Evolution (LTE) radio technology and robustness to hardware impairments.
Biliary stenting: Indications, choice of stents and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline (2012)

This article is part of a combined publication that expresses the current view of the European Society of Gastrointestinal Endoscopy about endoscopic biliary stenting. The present Clinical Guideline describes short-term and long-term results of biliary stenting depending on indications and stent models; it makes recommendations on when, how, and with which stent to perform biliary drainage in most common clinical settings, including in patients with a potentially resectable malignant biliary obstruction and in those who require palliative drainage of common bile duct or hilar strictures. Treatment of benign conditions (strictures related to chronic pancreatitis, liver transplantation, or cholecystectomy, and leaks and failed biliary stone extraction) and management of complications (including stent revision) are also discussed. A two-page executive summary of evidence statements and recommendations is provided. A separate Technology Review describes the models of biliary stents available and the stenting techniques, including advanced techniques such as insertion of multiple plastic stents, drainage of hilar strictures, retrieval of migrated stents and combined stenting in malignant biliary and duodenal obstructions.The target readership for the Clinical Guideline mostly includes digestive endoscopists, gastroenterologists, oncologists, radiologists, internists, and surgeons while the Technology Review should be most useful to endoscopists who perform biliary drainage.
Adaptive Left Ventricular Ejection Time Estimation Using Multiple Peripheral Pressure Waveforms (2005)

An adaptive approach is proposed for the problem of left ventricular ejection time (LVET) estimation using peripheral pressure waveform signals. The proposed algorithm, which makes use of 2 peripheral pressure measurements, makes it possible to adaptively estimate the LVET in response to different cardiovascular physiologic states. The algorithm builds on features obtained from global and branch-specific characterization of the cardiovascular circulation as well as waveform features to dramatically improve the accuracy of LVET estimation. The performance of the proposed approach is evaluated with respect to its heart-rate-based conventional counterpart, which shows approximately 40% improvement of estimation accuracy in terms of R<sup>2</sup>values □ from 0.6655 for the conventional waveform-based approach to 0.9222 for the proposed approach.
HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts (2020)

Aging has been characterized with the accumulation of oxidized proteins, as a consequence of progressive decline in proteostasis capacity. Among others, proteasomal system is an efficient protein turnover complex to avoid aggregation of oxidized proteins. Heat shock protein 70 (HSP70) is another critical player that is involved in some key processes including the correct folding of misfolded proteins and targeting aggregated proteins to the proteasome for rapid degradation. The aim of this study was to determine the role of proteasomal system and heat shock proteins to maintain proteome balance during replicative senescence in mild hyperthermia conditions. Our results demonstrated that HSP40/70 machinery is induced by mild hyperthermia conditions independent from senescence conditions. Since HSP70 is largely responsible for the rapidly inducible cell protection following hyperthermia, the activation of "heat shock response" resulted in the elevation of HSP40/70 expressions as well as the proteasome activity. Interestingly, when HSP70 expression was inhibited, increased proteasomal activation was shown to be responsive to mild hyperthermia. Since HSP70 is involved in various stress-related pathways such as oxidative and endoplasmic reticulum stress, depletion of HSP70 expression may induce proteasomal degradation to maintain proteome balance of the cell. Thus, our data suggests that in mild heat stress conditions, molecular chaperone HSP70 plays an important role to avoid protein oxidation and aggregation; however, activities of proteasomal system are induced when HSP70 expression is depleted.
DeepABM: Scalable, efficient and differentiable agent-based simulations\n via graph neural networks (2021)

We introduce DeepABM, a framework for agent-based modeling that leverages\ngeometric message passing of graph neural networks for simulating action and\ninteractions over large agent populations. Using DeepABM allows scaling\nsimulations to large agent populations in real-time and running them\nefficiently on GPU architectures. To demonstrate the effectiveness of DeepABM,\nwe build DeepABM-COVID simulator to provide support for various\nnon-pharmaceutical interventions (quarantine, exposure notification,\nvaccination, testing) for the COVID-19 pandemic, and can scale to populations\nof representative size in real-time on a GPU. Specifically, DeepABM-COVID can\nmodel 200 million interactions (over 100,000 agents across 180 time-steps) in\n90 seconds, and is made available online to help researchers with modeling and\nanalysis of various interventions. We explain various components of the\nframework and discuss results from one research study to evaluate the impact of\ndelaying the second dose of the COVID-19 vaccine in collaboration with clinical\nand public health experts. While we simulate COVID-19 spread, the ideas\nintroduced in the paper are generic and can be easily extend to other forms of\nagent-based simulations. Furthermore, while beyond scope of this document,\nDeepABM enables inverse agent-based simulations which can be used to learn\nphysical parameters in the (micro) simulations using gradient-based\noptimization with large-scale real-world (macro) data. We are optimistic that\nthe current work can have interesting implications for bringing ABM and AI\ncommunities closer.\n
Treatment of Hepatitis C Virus Reinfection after Liver Transplantation (2005)

Most liver transplant recipients become reinfected with hepatitis C virus after OLT followed by allograft dysfunction, transplant cirrhosis and graft failure in a significant proportion of patients. Both in the pre-emptive prophylactic setting and in the treatment setting sustained virological response rates are poor compared to the precirrhotic hepatitis state. Patients with significant hepatitis should be always treated before developing cirrhosis or even with early cirrhosis. After transplantation pegylated interferon in combination with ribavirin is the most successful treatment opportunity to date, however the best time point and treatment duration as well as doses for pegylated interferons and rebavirin have to be defined.
13C NMR Relaxation Rates in the Ionic Liquid 1-Methyl-3-nonylimidazolium Hexafluorophosphate (2005)

A new method of obtaining molecular reorientational dynamics from 13C spin-lattice relaxation data of aromatic carbons in viscous solutions is applied to 13C relaxation data of the ionic liquid, 1-methyl-3-nonylimidazolium hexafluorophosphate ([MNIM]PF6). Spin-lattice relaxation times (13C) are used to determine pseudorotational correlation times for the [MNIM]PF6 ionic liquid. Pseudorotational correlation times are used to calculate corrected maximum NOE factors from a combined isotropic dipolar and nuclear Overhauser effect (NOE) equation. These corrected maximum NOE factors are then used to determine the dipolar relaxation rate part of the total relaxation rate for each aromatic 13C nucleus in the imidazolium ring. Rotational correlation times are compared with viscosity data and indicate several [MNIM]PF6 phase changes over the temperature range from 282 to 362 K. Modifications of the Stokes-Einstein-Debye (SED) model are used to determine molecular radii for the 1-methyl-3-nonylimidazolium cation. The Hu-Zwanzig correction yields a cationic radius that compares favorably with a DFT gas-phase calculation, B3LYP/(6-311+G(2d,p)). Chemical shift anisotropy values, delta sigma, are obtained for the ring and immediately adjacent methylene and methyl carbons in the imidazolium cation. The average delta sigma values for the imidazolium ring carbons are similar to those of pyrimidine in liquid crystal solutions.
Coupled-Magnetic Filters With Adaptive Inductance Cancellation (2006)

Conventional filter circuits suffer from a number of limitations, including performance degradation due to capacitor parasitic inductance and the size and cost of magnetic elements. Coupled-magnetic filters have been developed that provide increased filter order with a single magnetic component, but also suffer from parasitic inductance in the filter shunt path due to imperfectly-controlled coupling of the magnetics. In this paper, we introduce a new approach to coupled-magnetic filters that overcomes these limitations. Filter sensitivity to variations in coupling is overcome by adaptively tuning the magnetic circuit for minimum rms ripple performance with feedback based on the sensed filter output ripple. This active control enables much greater robustness to manufacturing and environmental variations than is possible in the conventional "zero-ripple" coupled-magnetic approach, while preserving its advantages. Moreover, the proposed technique also adaptively cancels the deleterious effects of capacitor parasitic inductance, thereby providing much higher filter performance than is achievable in conventional designs. The new technique is experimentally demonstrated in a dc-dc power converter application and is shown to provide high performance
Genomic prediction of alcohol-related morbidity and mortality (2020)

While polygenic risk scores (PRS) have been shown to predict many diseases and risk factors, the potential of genomic prediction in harm caused by alcohol use has not yet been extensively studied. Here, we built a novel polygenic risk score of 1.1 million variants for alcohol consumption and studied its predictive capacity in 96,499 participants from the FinnGen study and 39,695 participants from prospective cohorts with detailed baseline data and up to 25 years of follow-up time. A 1 SD increase in the PRS was associated with 11.2 g (=0.93 drinks) higher weekly alcohol consumption (CI = 9.85-12.58 g, p = 2.3 × 10<sup>-58</sup>). The PRS was associated with alcohol-related morbidity (4785 incident events) and the risk estimate between the highest and lowest quintiles of the PRS was 1.83 (95% CI = 1.66-2.01, p = 1.6 × 10<sup>-36</sup>). When adjusted for self-reported alcohol consumption, education, marital status, and gamma-glutamyl transferase blood levels in 28,639 participants with comprehensive baseline data from prospective cohorts, the risk estimate between the highest and lowest quintiles of the PRS was 1.58 (CI = 1.26-1.99, p = 8.2 × 10<sup>-5</sup>). The PRS was also associated with all-cause mortality with a risk estimate of 1.33 between the highest and lowest quintiles (CI = 1.20-1.47, p = 4.5 × 10<sup>-8</sup>) in the adjusted model. In conclusion, the PRS for alcohol consumption independently associates for both alcohol-related morbidity and all-cause mortality. Together, these findings underline the importance of heritable factors in alcohol-related health burden while highlighting how measured genetic risk for an important behavioral risk factor can be used to predict related health outcomes.
Mobile Genome Express (MGE): A comprehensive automatic genetic analyses pipeline with a mobile device (2017)

The development of next-generation sequencing (NGS) technology allows to sequence whole exomes or genome. However, data analysis is still the biggest bottleneck for its wide implementation. Most laboratories still depend on manual procedures for data handling and analyses, which translates into a delay and decreased efficiency in the delivery of NGS results to doctors and patients. Thus, there is high demand for developing an automatic and an easy-to-use NGS data analyses system. We developed comprehensive, automatic genetic analyses controller named Mobile Genome Express (MGE) that works in smartphones or other mobile devices. MGE can handle all the steps for genetic analyses, such as: sample information submission, sequencing run quality check from the sequencer, secured data transfer and results review. We sequenced an Actrometrix control DNA containing multiple proven human mutations using a targeted sequencing panel, and the whole analysis was managed by MGE, and its data reviewing program called ELECTRO. All steps were processed automatically except for the final sequencing review procedure with ELECTRO to confirm mutations. The data analysis process was completed within several hours. We confirmed the mutations that we have identified were consistent with our previous results obtained by using multi-step, manual pipelines.
A Set-Up of 7 Laser Triangulation Sensors and a Draw-Wire Sensor for Measuring Relative Displacement of a Piston Rod Mechanical Lead-Through Transmission in an Offshore Wave Energy Converter on the Ocean Floor (2012)

A concept for offshore wave energy conversion is being developed at the Swedish Centre for Renewable Electric Energy Conversion at Uppsala University in Sweden. The wave energy converter (WEC) in focus contains a piston rod mechanical lead-through transmission for transmitting the absorbed mechanical wave energy through the generator capsule wall while preventing seawater from entering the capsule. A set-up of 7 laser triangulation sensors has been installed inside the WEC to measure relative displacement of the piston rod and its corresponding seal housing. A draw-wire sensor has also been set up to measure translator position and the axial displacement of the piston rod. The paper gives a brief introduction to the Lysekil research site, the WEC concept, and the direct drive of WEC prototype L2. A model of operation for the piston rod mechanical lead-through transmission is given. The paper presents sensor choice, configuration, adaptation, mounting, and measurement system calibration along with a description of the data acquisition system. Results from 60 s measurements of nominal operation two months apart with centered moving averages are presented. Uncertainty and error estimations with statistical analyses and signal-to-noise ratios are presented. Conclusions are drawn on the relative motions of the piston rod and the seal housing under normal operating conditions, and an assessment of the applicability of the measurement system is made.
Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy (2017)

Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC). CTT can arise in metastatic testicular GCT in treatment naïve patients. An important differential diagnosis is choriocarcinoma due to treatment implications, and SALL4 IHC may help.
Tumor control after surgery and radiotherapy for pineocytoma (2010)

Gross-total resection is the ideal treatment for pineocytoma and might represent a cure for these lesions. When gross-total resection is not possible, adjuvant radiation therapy after STR is of questionable benefit for these patients.
A Simulator for Trading Traffic Privileges by Selfish Driving Cars (2020)

Connected autonomous vehicles are an important class of cyber-physical systems that are expected to have a major impact on society. Connectivity and autonomy in next-generation automobiles can be leveraged to improve safety and efficiency of our transportation systems. This paper presents a novel approach for incorporating individual driving preferences of vehicles in a computational framework to allow dynamic assignment and transfer of right-of-way privileges between cars as they navigate contested road segments. Dynamic priorities based on time of arrival estimates and positions in queues are used to unambiguously identify the owners of right-of-way privileges to conflict zones at any given time. A mechanism for transferring the privileges from a unique rightful owner to another car, possibly incentivized by using a shared currency, is proposed. A simulation framework using MATLAB® is developed to enable rigorous study of this mechanism across tens of thousands of simulations.
A QoS-aware proportional fair scheduler for opportunistic OFDM (2005)

OFDM is an attractive technique to implement multiuser diversity for the downlink. This paper deals with the problem of combining the increased cell throughput of multiuser diversity schemes with a fair distribution of resources among the users. A proportional fair scheduler for opportunistic OFDM is proposed. Its key features are that it can accommodate several quality-of-service (QoS) classes, that it has a tunable fairness level, and that it can be integrated with an opportunistic beamformer to increase system fairness. Simulation results show that the cell throughput of the opportunistic scheme approaches that of a more complex smart antenna scheme for many users. For a densely populated system, the proposed scheme shows a graceful QoS degradation, possibly leading to a high average user satisfaction. The fairness parameter effectively tunes the scheduler between high cell throughput and high fairness.