gebhart/patrepeval huggingface dataset:
Flexible Thin-Film InGaAs Photodiode Focal Plane Array (2016)

Natural imaging systems such as the retina and the compound eye employ a conformal architecture that provides an aberration-free image with wide field of view (FOV) and very low f/number. However, most artificial imagers such as conventional cameras are limited to a planar architecture demanded by the use of brittle semiconductor focal plane arrays (FPAs). High-resolution image formation on this flat field requires multiple bulky optical elements. Here we demonstrate a general approach to fabricating complex circuits and in particular FPAs on flexible and/or conformable substrates that can be shaped to overcome these fundamental limitations. An 8 × 100, lightweight, thin-film In0.53Ga0.47As p-i-n photodiode FPA with sensitivity to wavelengths as long as λ = 1650 nm is fabricated on a thin flexible plastic foil following transfer by adhesive-free bonding of the epitaxial layers that are subsequently lifted off from the parent InP substrate. The array is shaped into either a convex cylindrically curved imager to achieve a 2π FOV or, when formed into a concave shape, to provide high-resolution and compact spectral decomposition over a wide wavelength range. The array exhibits ∼99% fabrication yield with ∼100% peak external quantum efficiency at λ = 1300 nm. The unique features of this flexible thin-film FPA provide a new paradigm for realizing advanced electronic and imaging applications.
Advanced dynamic failure analysis on interconnects by vectorized Scanning Joule Expansion microscopy (2009)

Vertical and lateral Scanning Joule Expansion Microscopy measurements are compared for the first time. Frequency behaviors of the thermal-mechanical system are analyzed by introducing equivalent circuits for thermo-elastic transport mechanisms. Advanced failure analysis on degradation processes of interconnects can be performed by increasing temperature sensitivities and spatial resolutions.
Phase Compatibility and Superconductivity of Y-Ba-Cu-O Compounds (1988)

Superconducting properties of Y-Ba-Cu-O compounds were investigated in relation to precipitation of second phases. Contour lines of J c , T c and diamagnetic signal intensities were presented in the YO 1.5 -BaO-CuO system. These superconducting properties decreased steeply with BaCuO 2 precipitation, and the maximum J c was obtained in the yttrium-rich composition of Y 1.2 Ba 2 Cu 3 O 7- y . It is considered, therefore, that the BaCuO 2 precipitating around the YBa 2 Cu 3 O 7- y grains interrupt the superconducting current pass at the grain boundary. Yttrium-rich composition, which inhibits BaCuO 2 precipitation, is effective for the preparation of the high- J c sample.
Short‐term studies on the in vivo metabolism ofN‐oxides of nicotine in rats (1986)

This study was designed to examine the in vivo reduction of the N-oxidation products of nicotine metabolism in rats. Male Fischer-344 rats were divided into one control and three experimental groups (n = 20). Each treatment group received either 0.02% trans-nicotine N'-oxide, 0.02% cis-nicotine N'-oxide, or 0.02% nicotine N,N'-dioxide in drinking water for 3 wk. After 7 d of metabolite administration, plasma nicotine levels in the trans-nicotine N'-oxide group rose to twice that of the cis-nicotine N'-oxide or nicotine N,N'-dioxide group. Plasma cotinine [1-methyl-5-(3-pyridinyl)-2-pyrrolidinone] concentrations reached maximum levels during wk 1 in the cis-nicotine N'-oxide and nicotine N,N'-dioxide groups but continued to increase for another 7 d in the trans-nicotine N'-oxide group. At d 15 and again at d 21, rats from each group (n = 10) were placed in metabolism chambers and given 50 ml tap water over a 24-h period. Analysis of urine obtained from a metabolism-chamber study conducted after 15 d of consumption revealed concentrations of nicotine in the trans-nicotine N'-oxide group that were 3 times higher than cis-nicotine N'-oxide-treated animals. Urinary cotinine levels were similar in all three groups. Results from a second chamber study (d 21) showed similar urinary nicotine and cotinine values in all treatment groups. Plasma total triiodothyronine (TT3) concentrations were reduced in all treatment groups during the first week. Plasma total thyronine (TT4) concentrations were reduced (p less than 0.05) in the trans-nicotine N'-oxide and cis-nicotine N'-oxide treatment groups during the first week. Plasma total thyronine (TT4) concentrations cis-nicotine N'-oxide is presented. An analytical method for separation of nicotine, cotinine, and cis- and trans-nicotine N'-oxide, as well as cis- and trans-nicotine N,N'-dioxide, is also outlined.
Real-time images of tidal recruitment using lung ultrasound (2015)

Lung ultrasound was helpful in detecting the presence of atelectasis and tidal recruitment and in confirming their resolution after a lung recruitment maneuver.
Faculty Opinions recommendation of Risk of interstitial lung disease with gefitinib and erlotinib in advanced non-small cell lung cancer: a systematic review and meta-analysis of clinical trials. (2014)

Read the full review for this Faculty Opinions recommended article: Risk of interstitial lung disease with gefitinib and erlotinib in advanced non-small cell lung cancer: a systematic review and meta-analysis of clinical trials.
Improvement of Inhibitor Identification for Heat Shock Protein 90α by Utilizing a Red-Shifted Fluorescence Polarization Probe (2012)

Heat shock protein-90 (HSP90) is an ATP-dependent molecular chaperone with intrinsic ATPase activity. HSP90 is required for the stability and function of client proteins, many of which are involved in oncogenesis. Thus, identification of HSP90 inhibitors would potentially lead to the discovery of cancer therapeutics. Here, we present a high-throughput screening campaign utilizing two geldanamycin (GM)-labeled probes in a fluorescence polarization (FP) assay. For the primary screen, a previously reported green BODIPY-labeled GM (GM-BODIPY) was used to evaluate a library collection of about 400,000 compounds. From this screen, 3058 compounds showed >30% inhibition. To distinguish true positives from compound interference, a confirmatory screen was deemed necessary. Accordingly, a red-shifted FP binding assay was developed using GM labeled with red BODIPY. This tool enabled reliable identification of promising HSP90α inhibitors.
Study on the catalytic performance of different crystal morphologies of HZSM-5 zeolites for the production of biodiesel: a strategy to increase catalyst effectiveness (2019)

Strategies to improve molecular transport and accessibility of ZSM-5 zeolites were investigated for the model reaction of esterification of linoleic acid with methanol for biodiesel production.
CFD As Applied to the Development of a Hydrodynamic Vortex Mixer (2011)

Faced with the challenge of retrofitting a new sludge mixing and blending system into their wastewater treatment plant, the Middle Basin WWTP chose to adapt a non-powered vortex mixing technology typically used for CSO treatment. The resulting Hydrodynamic Vortex Mixer was analyzed to be fit for purpose using CFD simulations before it was fabricated, installed and tested. This paper outlines the development process for this custom "vortex mixer" from initial concept through preliminary CFD to the ultimate testing of the actual constructed unit. Assumptions made during the modeling process and how those assumptions were challenged during the testing phase of the project are described. As predicted by the engineering analysis, the unit worked as designed, creating a homogeneous mixture in a compact and energy efficient system. This highlights the flexibility of advanced hydrodynamic vortex systems within the field of urban water management including wastewater as well as CSO applications.
Multilayer deposition on patterned posts using alternating polyelectrolyte droplets in a microfluidic device (2010)

We demonstrate that polyelectrolyte (PE) multilayer thin films deposited on patterned posts with incredibly large numbers of bilayers, which would not be possible with the conventional Layer-by-Layer (LbL) deposition methods, can be obtained in a short process time using alternating polyelectrolyte droplets generated in a microfluidic channel, representing a significant advantage over the conventional processes based on polyelectrolyte deposition followed by the separation of such substrates (typically colloidal particles) with centrifugation and sonication. Positively- and negatively-charged polyelectrolyte droplets were alternatively generated in a microfluidic channel by controlling the capillary number (Ca) as well as the fraction of dispersed phase over the continuous phase. Patterned posts, serving as the substrates for the PE deposition, were created with photo-curable polymers using the optofluidic maskless lithography. The impact of these PE droplets onto the patterned posts allowed the alternative adsorption of PEs, similar to the conventional LbL deposition methods. It was shown that the intensity of fluorescence dye tagged onto (+)-charged PEs adsorbed on the post(s), taken with confocal laser scanning microscopy, increases with deposition time and varies around the post(s). The effect of post shape and interval between the two posts for the droplet-based LbL deposition was also experimentally investigated and analyzed, in connection with the numerical simulations, to elucidate the underlying principles of relevant two-phase flows.
Deadbolt (2013)

Android devices use volume encryption to protect private data storage. While this paradigm has been widely adopted for safeguarding PC storage, the always-on mobile usage model makes volume encryption a weaker proposition for data confidentiality on mobile devices. PCs are routinely shut down which effectively secures private data and encryption keys. Mobile devices, on the other hand, typically remain powered-on for long periods and rely on a lock-screen for protection. This leaves lock-screen protection, something routinely bypassed, as the only barrier securing private data and encryption keys. Users are unlikely to embrace a practice of shutting down their mobile phones, as it impairs their communication and computing abilities. We propose Deadbolt: a method for maintaining most mobile computing functionality, while offering the security benefits of a powered off device with respect to storage encryption. Deadbolt prevents access to internal storage even if the adversary can exploit a lock screen bypass vulnerability or perform a cold boot attack. Users can gracefully switch between the Deadbolt and unlocked modes in less time than a system reboot. Deadbolt offers the additional benefit of an incognito environment in which logs and actions will not be recorded.
Additions and Corrections - Watching Silver Clusters Grow in Zeolites: Direct Probe Fourier Transform-Far-Infrared Spectroscopy of the Red Form of Fully Silver Ion Exchanged Zeolite A. (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleAdditions and Corrections - Watching Silver Clusters Grow in Zeolites: Direct Probe Fourier Transform-Far-Infrared Spectroscopy of the Red Form of Fully Silver Ion Exchanged Zeolite A.Mark Baker, John Godber, and Geoffrey OzinCite this: J. Phys. Chem. 1985, 89, 21, 4658Publication Date (Print):October 1, 1985Publication History Published online4 September 2003Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/j100267a601https://doi.org/10.1021/j100267a601research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
An Investigation of the Differential Effects of Ursane Triterpenoids fromCentella asiatica, and Their Semisynthetic Analogues, onGABAAReceptors (2016)

The ursane triterpenoids, asiatic acid 1 and madecassic acid 2, are the major pharmacological constituents of Centella asiatica, commonly known as Gotu Kola, which is used traditionally for the treatment of anxiety and for the improvement of cognition and memory. Using the two-electrode voltage-clamp technique, these triterpenes, and some semisynthetic derivatives, were found to exhibit selective negative modulation of different subtypes of the GABAA receptor expressed in Xenopus laevis oocytes. Despite differing by only one hydroxyl group, asiatic acid 1 was found to be a negative modulator of the GABA-induced current at α1 β2 γ2L, α2 β2 γ2L and α5 β3 γ2L GABAA receptors, while madecassic acid 2 was not. Asiatic acid 1 exhibited the greatest effect at α1 β2 γ2L (IC50 37.05 μm), followed by α5 β3 γ2L (IC50 64.05 μm) then α2 β2 γ2L (IC50 427.2 μm) receptors. Conversion of the carboxylic acid group of asiatic acid 1 to a carboxamide group (2α,3β,23-trihydroxy-urs-12-en-28-amide 5) resulted in enhanced inhibition at both the α1 β2 γ2L (IC50 14.07 μm) and α2 β2 γ2L receptor subtypes (IC50 28.41 μm). The results of this study, and the involvement of α5 -containing GABAA receptors in cognition and memory, suggest that asiatic acid 1 may be a lead compound for the enhancement of cognition and memory.
Preclinical Characterization of a Novel Diphenyl Benzamide Selective ERα Agonist for Hormone Therapy in Prostate Cancer (2012)

Androgen deprivation therapy (ADT) is the mainstay of treatment for advanced prostate cancer. ADT improves overall and disease-free survival rates, but long-term therapy is associated with severe side effects of androgen and estrogen depletion including hot flashes, weight gain, depression, and osteoporosis. Effective hormone reduction can be achieved without estrogen deficiency-related side effects by using therapy with estrogenic compounds. However, cardiovascular complications induced by estrogens coupled with the availability of LHRH agonists led to discontinuation of estrogen use for primary androgen deprivation therapy in the 1980s. New treatments for prostate cancer that improve patient outcomes without the serious estrogen deficiency-related toxicities associated with ADT using LHRH analogs are needed. Herein we describe a novel nonsteroidal selective estrogen receptor-α agonist designed for first-line therapy of advanced prostate cancer that in animal models induces medical castration and minimizes many of the estrogen deficiency-related side effects of ADT. The present studies show that orally administered GTx-758 reversibly suppressed testosterone to castrate levels and subsequently reduced prostate volume and circulating prostate-specific antigen in relevant preclinical models without inducing hot flashes, bone loss, thrombophilia, hypercoagulation, or increasing fat mass.
Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation. (1985)

Poly-adenosine diphosphate (ADP)-ribosylation of nuclear proteins has been demonstrated previously to be activated in vivo by the presence of DNA single-strand breaks and has thus been implicated to play an important role in altering chromatin structure during cellular recovery from DNA damage. Based upon these considerations, a novel immunofractionation method, using antipoly(ADP-ribose) coupled to Sepharose, has been used to enrich for those limited domains of chromatin undergoing poly-ADP-ribosylation. We have used three independent methods to verify the presence of significant levels of single-strand DNA breaks adjacent to polynucleosomes engaged in ADP-ribosylation.
Carbon Nanotubes in Microelectronic Applications (2008)

This chapter contains sections titled: Introduction Carbon Nanotube Basics Carbon Nanotube Interconnects Carbon Nanotube Devices Conclusions Acknowledgments References
Where's the "party" in "multi-party"? (2006)

Spontaneous multi-party interaction -- conversation among groups of three or more participants -- is part of daily life. While automated modeling of such interactions has received increased attention in ubiquitous computing research, there is little applied research on the organization of this highly dynamic and spontaneous sociable interaction within small groups. We report here on an applied conversation analytic study of small-group sociable talk, emphasizing structural and temporal aspects that can inform computational models. In particular, we examine the mechanics of multiple simultaneous conversational floors -- how participants initiate a new floor amidst an on-going floor, and how they subsequently show their affiliation with one floor over another. We also discuss the implications of these findings for the design of "smart" multi-party applications.
Improving UHMWPE Using Electron Beam Irradiation (2005)

Department of Orthopaedic Surgery, Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Harvard Medical School,Boston, Massachusetts, U.S.A.INTRODUCTIONUltra high molecular weight polyethylenea has been the material of choice for bearing surfaces used in total hip and knee arthroplasty for 40 years and polyethylene has been successfully used in acetabular components, tibial inserts, and patella buttons. Yet there are certain in vivo damage mechanisms associated with this material that can compromise device performance.
Optimal sampling strategies for multiscale models with application to network traffic estimation (2004)

The paper considers the problem of determining which set of 2/sup p/ leaf nodes on a binary multiscale tree model of depth N (N < p) gives the best linear minimum mean-squared estimator of the tree root. We find that the best-case and worst-case sampling choices depend on the correlation structure of the tree. This problem arises in Internet traffic estimation, where the goal is to estimate the average traffic rate on a network path based on a limited number of traffic samples.
Vertical GaN Power Devices: Device Principles and Fabrication Technologies—Part I (2021)

Recent years have witnessed a tremendous development of vertical gallium nitride (GaN) power devices, a new class of device technology that could be the key enabler for next-generation high performance power electronics. In this comprehensive review, we discuss the recent progress made on vertical GaN power devices, highlighting their important device design principles and fabrication processes. Part I of the two-part review series introduces the basic design principles of vertical GaN devices using Schottky barrier diodes (SBDs) and p-n diodes as examples. We provide a comprehensive review and in-depth analysis on their basic structures, fabrication processes, and device physics. Materials engineering, including buffer layer and drift layer design, and device engineering, including various edge termination methods, are elucidated. Key device topics, including avalanche breakdown and leakage mechanisms of vertical GaN power devices, are also discussed. We also examine various approaches and provide detailed descriptions of the key knowledge obtained. This timely review provides valuable information for the power electronics community and can inspire researchers for future interdisciplinary collaborations in this emerging and exciting research field.
Abstract 5333: Novel Ab treatment tool for CRC (2010)

Abstract Background: We have shown that CD24, a cell surface molecule, is overexpressed early in the multistep process of colorectal neoplasia (Gastroenterology, 2006) hence, it can serve as a target for early detection and immunotherapy. The anti-CD24 murine SWA11 Mab (generous gift from Prof. Sthal, Zurich University) binds to CD24 and inhibits tumor cell growth, in vitro and in vivo, in a time- and dose-dependent manner (Cancer Research, 2008). However, murine Mabs have limitations because of their xenogeneic nature and due to the human anti-mouse antibody (HAMA) response. Aim: To produce an improved, chimeric form of the SWA11 Mab. Methods: Mammalian vector pMAZ-IgH for human γ1 heavy-chain and pMAZ-IgL for human κ light chain expression were designed. The variable region genes encoding the murine anti-CD24 SWA11 MAb were cloned for expression as chimeric γ1/kappa antibody into the mammalian pMAZ-IgH and pMAZ-IgL expression vectors and co-transfected into HEK293 cells. Stable clones were screened and selected for IgG production, analyzed by whole-cell and antigen-based ELISA, and Western blotting. Results: The new chimeric IgG derivative of the anti-CD24 SWA11 Mab possesses similar affinity and specificity (ELISA and Western blot), but has improved activity in inhibiting cell growth. The chimeric Mabs also have the ability to induce complement-dependent cytotoxicity, causing up to 60% cell lysis in the presence of complement. Conclusions: We had successfully generated a chimeric IgG derivative of the anti-CD24 SWA11 Mab that can serve as a novel therapeutic tool for cancer cells harboring CD24. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5333.
Using feedback for secrecy over graphs (2013)

We study the problem of secure message multicasting over graphs in the presence of a passive (node) adversary who tries to eavesdrop in the network. We show that use of feedback, facilitated through the existence of cycles or undirected edges, enables higher rates than possible in directed acyclic graphs of the same mincut. We demonstrate this using code constructions for canonical combination networks (CCNs). We also provide general outer bounds as well as schemes for node adversaries over CCNs.