gebhart/patrepeval huggingface dataset:
Functional multi-layer graphene–algae hybrid material formed using vortex fluidics (2012)

Dynamic thin films confined in a microfluidic platform are effective in exfoliating graphite in water and then decorating the multi-layer 2D sheets on the surface of microalgal cells. The overall process incorporates green chemistry principles in using naturally available resources, namely algae and graphite, and using water as a benign reaction medium. Furthermore, the nanobio hybrid material is active for wastewater treatment, in removing all traces of nitrate from liquid effluents, more efficiently than the pristine microalgal cells, with the multi-layer graphene itself not showing any significant nitrate removal.
Doping Induced Polymorph and Carrier Polarity Changes in LaSeF (2018)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDoping Induced Polymorph and Carrier Polarity Changes in LaSeFTakeshi Arai†, Soshi Iimura*†, and Hideo Hosono*†‡View Author Information† Laboratory for Materials and Structures, Tokyo Institute of Technology, Yokohama 226-8503, Japan‡ Research Center for Element Strategy, Tokyo Institute of Technology, Yokohama 226-8503, Japan*S.I., e-mail: [email protected]*H.H., e-mail: [email protected]Cite this: Chem. Mater. 2018, 30, 3, 597–601Publication Date (Web):January 15, 2018Publication History Received12 December 2017Revised11 January 2018Published online17 January 2018Published inissue 13 February 2018https://pubs.acs.org/doi/10.1021/acs.chemmater.7b05161https://doi.org/10.1021/acs.chemmater.7b05161rapid-communicationACS PublicationsCopyright © 2018 American Chemical SocietyRequest reuse permissionsArticle Views717Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Doping,Electrical conductivity,Semiconductors,Thermodynamic modeling Get e-Alerts
Molecular cloning and genetic analysis of a chloramphenicol acetyltransferase determinant from Clostridium difficile (1988)

A gene bank from a clinical isolate of Clostridium difficile expressing high chloramphenicol acetyltransferase activity was constructed by cloning Sau3A-cleaved clostridial DNA fragments into the plasmid vector pUC13. Among 1,020 clones tested, 11 were resistant to chloramphenicol; 1 of these, with an insert size of 1.9 kilobases (pPPM9), was studied further. The clone pPPM9 was mapped using a variety of restriction enzymes, and a 0.27-kilobase EcoRV-TaqI restriction fragment was shown to be within the chloramphenicol resistance (Cmr) gene by using transposon (Tn1000) mutagenesis. The 0.27-kilobase fragment and the 1.9-kilobase insert were radiolabeled and used as DNA probes in hybridization studies. Southern blot analysis with the gene probes against chromosomal DNA from Cmr strains of C. difficile obtained from five distinct geographical locations revealed that at least two copies of the same chloramphenicol acetyltransferase gene were present for each strain. Hybridization of the gene probes against Cmr strains of Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella edwardsii, Escherichia coli, and to four other clostridial species revealed no homology even under conditions of low stringency.
A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells (2018)

LSEVh-LS-F exhibits broad HIV-1 neutralizing activity and enhanced ADCC against HIV-1-infected cells, reactivated latently infected cell lines and primary CD4+ T cells, thus being a promising candidate therapeutic for eradicating the HIV-1 reservoir.
High surface area silicon carbide-coated carbon aerogel (2023)

A metal oxide-carbon composite includes a carbon aerogel with an oxide overcoat. The metal oxide-carbon composite is made by providing a carbon aerogel, immersing the carbon aerogel in a metal oxide sol under a vacuum, raising the carbon aerogel with the metal oxide sol to atmospheric pressure, curing the carbon aerogel with the metal oxide sol at room temperature, and drying the carbon aerogel with the metal oxide sol to produce the metal oxide-carbon composite. The step of providing a carbon aerogel can provide an activated carbon aerogel or provide a carbon aerogel with carbon nanotubes that make the carbon aerogel mechanically robust. Carbon aerogels can be coated with sol-gel silica and the silica can be converted to silicone carbide, improved the thermal stability of the carbon aerogel.
Protective effect of propranolol on mitochondrial function in the ischaemic heart (2002)

1. The present study was aimed to determine whether propranolol improves contractile function of the ischaemic/reperfused heart through protection of the mitochondrial function during ischaemia. 2. Isolated perfused rat hearts were subjected to 35-min ischaemia followed by 60-min reperfusion. Pre-treatment with propranolol at the concentrations of 10 to 100 microM for the final 3 min of pre-ischaemia resulted in the improvement of ischaemia/reperfusion-induced contractile dysfunction, release of creatine kinase (CK) into perfusate, and decrease in myocardial high-energy phosphates. Propranolol also attenuated ischaemia-induced accumulation in Na+, suggesting that cytosolic sodium overload during ischaemia was prevented by propranolol. 3. The mitochondrial oxygen consumption rate of skinned bundles from the perfused heart decreased at the end of ischaemia and it further decreased at the end of reperfusion. These decreases were cancelled by treatment with propranolol. A release of cytochrome c from the perfused heart was observed during ischaemia, and this release was suppressed by treatment with propranolol. 4. To elucidate the direct effect of propranolol on mitochondria, the mitochondria were isolated from normal hearts and their activities were determined in the presence of various concentrations of Na+ and propranolol. The addition of sodium lactate, which mimicked sodium overload in the ischaemic heart, reduced the state 3 respiration, whereas this reduction was not attenuated by the presence of propranolol. 5. These results suggest that cardioprotection of propranolol may be exerted via attenuating Na+ influx into cardiac cells followed by prevention of the mitochondrial dysfunction in the ischaemic heart, leading to improvement of energy production of the heart during reperfusion.
Thresholds optimization for one-bit feedback multi-user scheduling (2018)

We propose a new one-bit feedback scheme with scheduling decision based on the maximum expected weighted rate. We show the concavity of the 2-user case and provide the optimal solution which achieves the maximum weighted rate of the users. For the general asymmetric M-user case, we provide a heuristic method to achieve the maximum expected weighted rate. We show that the sum rate of our proposed scheme is very close to the sum rate of the full channel state information case, which is the upper bound performance. ? 2012 IEEE.
Proactive Approaches for Engine Health Management and a High Value Example (2022)

The rise of connectivity and big data has created the opportunity for advanced health management of machines, and the expectation of significant value to be gained through its application. In the case of gas turbine engines, this presents a challenge because the number of fielded engines is relatively small compared to other machines, and their extremely high reliability results in very few fault cases to use for machine learning. Nonetheless, the expectation that data will be used to manage unexpected issues still exists. This paper discusses some of the strategies used to proactively manage this challenge, and provides the example of the OPX (Oil Pressure Transducer) algorithm as applied to Honeywell turbofan engines. In this example, a Condition Indicator was initially developed to detect sensor failures, but as field experience was gained, its application spread to include oil pump and even carbon seal wear. The primary theme is how health management for gas turbine engines requires a slightly different approach than typical big data techniques, and how starting with a fundamental Condition Indicator and allowing its use to evolve with experience can lead to solutions that would be difficult to imagine in the early stages of conceptual design, or with machine learning on its own.
First report from India of haemolytic disease of newborn by anti-c and anti-E in Rh (D) positive mothers (2007)

In India, at the majority of the transfusion centers, antenatal antibody screening is done only in Rh (D) negative mothers. We report here two cases of haemolytic disease of newborn (HDN) by maternal alloimmunization to anti-c in one case, and both anti-c and anti-E in the second case. Both women were Rh (D) positive mothers and HDN was detected postnatally by a positive direct antiglobulin test (DAT) in their newborns. These cases highlight the importance of routine antenatal antibody screening even in Rh (D) positive females. A close follow-up throughout pregnancy is required if irregular antibodies are present so that antigen negative, crossmatch compatible blood can be provided in a timely manner for intra-uterine or exchange transfusions.
Diminished blocking effect of acute lead exposure on high-threshold voltage-gated calcium currents in PC12 cells chronically exposed to the heavy metal. (1998)

Rat pheochromocytoma (PC12) cells were grown in 0, 10, 25, or 50 microM lead-containing growth media for up to twelve weeks. High-threshold whole-cell calcium currents from these PC12 cells were recorded in lead-free recording media (control), then in 1 microM lead-containing recording media (acute challenge), and finally again in lead-free recording media (wash). The acute lead challenge decreased calcium currents in all treatment groups (including 0 microM lead). However, this blocking effect of acute lead application diminished with prolonged chronic exposure to 25 and 50 microM lead. Although the acute lead challenge mainly caused a decrease in calcium currents, in some chronically exposed PC12 cells increased calcium currents were recorded during the application of 1 microM lead acetate. In other chronically exposed PC12 cells, the acute lead challenge caused the peak of the current-voltage curve to shift from +10 mV to 0 mV. The number of cells exhibiting either an increase in calcium current or a shift in the current-voltage relationship following acute lead challenge increased with prolonged chronic exposure to the heavy metal. The time-dependent increase in calcium influx may be responsible for at least one manifestation of lead neurotoxicity.
EU FP7 INFSO-ICT-247223 ARTIST4G, D3.5c Moving Relays and Mobility aspects (2012)

This deliverable presents analysis and simulation results related to moving relays and mobility optimization for relay enhanced networks. The results reported in this deliverable are ranging from fundamental performance limits expressed in terms outage probability to practical implementations of the moving relay concepts through architecture discussion, coordinated moving relays and network coded moving relays.
Up‐regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability (2000)

Selective hippocampal cell loss and altered neurotransmitter receptor expression have been proposed as pathogenic mechanisms in the development of chronic mesial temporal lobe epilepsy (TLE). Studies in animal models point to metabotropic glutamate receptors (mGluRs) as modulators of hippocampal epileptogenesis. In addition, mGluRs may constitute specific targets for the development of novel anticonvulsive drugs. As mGluR4 represents an inhibitory class III mGluR associated with the reduction of intracellular cyclic AMP levels and calcium influx, we have analyzed the regional and cellular expression of mGluR4 in surgical hippocampal specimens obtained from patients with TLE by using immunohistochemistry and in situ hybridization. Although the hippocampi of control specimens (n = 11) were almost devoid of mGluR4 immunolabeling, all TLE specimens (n = 35) showed a striking up-regulation of mGluR4 immunoreactivity, in particular within the dentate gyrus. Immunoelectron microscopy localized the receptor protein to the periphery of presynaptic and postsynaptic membranes. In situ hybridization revealed increased transcript levels of mGluR4 in dentate granule cells and residual CA4 neurons of TLE specimens compared with controls. Our results suggest a potential role of mGluR4 in counteracting excitatory hippocampal activity and in modulating seizure-associated vulnerability of hippocampal neurons. These data may also provide a basis for pharmacological studies of mGluR4 agonists as potential novel drugs in the treatment of TLE. Ann Neurol 2000; 47:26–35
Exstrophy–Epispadias Complex in a Newborn: Case Report and Review of the Literature (2015)

Aim The aim of this report is to present a brief review of the current literature on the management of EEC. Case Report A term male neonate presented at birth with classic bladder exstrophy, a variant of the exstrophy-epispadias complex (EEC). The defect was covered with sterile silicon gauzes and waterproof dressing; at 72 hours of life, primary closure without osteotomy of bladder, pelvis, and abdominal wall was successfully performed. Discussion EEC incidence is approximately 2.15 per 1,00,000 live births; several urological, musculocutaneous, spinal, orthopedic, gastrointestinal, and gynecological anomalies may be associated to EEC. Initial medical management includes use of occlusive dressings to prevent air contact and dehydration of the open bladder template. Umbilical catheters should not be positioned. Surgical repair stages include initial closure of the bladder and abdominal wall with or without osteotomy, followed by epispadias repair at 6 to 12 months, and bladder neck repair around 5 years of life. Those who fail to attain continence eventually undergo bladder augmentation and placement of a catheterizable conduit. Conclusion Modern-staged repair of EEC guarantees socially acceptable urinary continence in up to 80% of cases; sexual function can be an issue in the long term, but overall quality of life can be good.
A Genetically Encoded Metabolically Stable Analogue of Phosphotyrosine in Escherichia coli (2007)

p-Carboxymethyl- l-phenylalanine (pCMF), a phosphotyrosine (pTyr) mimetic that is resistant to protein tyrosine phosphatase hydrolysis, was cotranslationally incorporated into proteins in Escherichia coli using an orthogonal amber suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair. The pCMF-specific aaRS was identified from a large library of Methanococcus jannaschii tyrosyl-tRNA synthetase active-site mutants by a combination of positive and negative genetic selections. When pCMF was substituted for Tyr701 in human signal transducer and activator of transcription-1 (STAT1), a constitutively active mutant was obtained that dimerizes and binds a DNA oligonucleotide duplex that contains the M67 site recognized by Tyr701-phosphorylated STAT1. Genetic incorporation of pCMF into proteins should provide a new tool for the preparation of stable analogues of a wide array of phosphoproteins involved in signal transduction pathways, as well as the development of peptide-based, cellularly expressed inhibitors of pTyr binding proteins.
SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays (2008)

Exon and exon+junction microarrays are promising tools for studying alternative splicing. Current analytical tools applied to these arrays lack two relevant features: the ability to predict unknown spliced forms and the ability to quantify the concentration of known and unknown isoforms. SPACE is an algorithm that has been developed to (1) estimate the number of different transcripts expressed under several conditions, (2) predict the precursor mRNA splicing structure and (3) quantify the transcript concentrations including unknown forms. The results presented here show its robustness and accuracy for real and simulated data.
Supplementary Figure S7 from Direct Detection and Quantification of Neoantigens (2023)

&lt;p&gt;Peptide recovery ratios.&lt;/p&gt;
Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis (2012)

Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.
Distinction Between Endometrial and Endocervical Adenocarcinoma: An Immunohistochemical Study (2002)

We investigated the possibility of distinguishing between primary endometrial and endocervical adenocarcinomas by using a panel of immunohistochemical stains, which included vimentin (VIM), carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and cytokeratins 7 and 20 (CK7 and CK20). Twenty-nine endocervical adenocarcinomas (CCAs) and 30 endometrial adenocarcinomas (EMCAs) including cases with overlapping histologic features (CCAs with endometrioid differentiation [15/29] and EMCAs with mucinous differentiation [16/30]) were evaluated. Most EMCAs (29/30, 97%) were VIM positive, whereas only 2/29 (7%) CCAs were VIM positive. The great majority of EMCAs (28/30) and all 29 CCAs were CK7 positive, whereas all 30 EMCAs and 27/29 CCAs were negative for CK20. CEA positivity was more common in CCAs (18/29, 62%) than in EMCAs (8/30, 27%). EMA positivity was present in all 30 EMCAs and in 26 of 29 (90%) CCAs. We conclude that VIM and CEA are useful immunohistochemical markers in distinguishing EMCAs and CCAs, but CK7, CK20, and EMA are not useful in this distinction.
High temperature thermometric phosphors (2023)

A high temperature phosphor consists essentially of a material having the general formula LuPO.sub.4 :Dy.sub.(x),Eu.sub.y) wherein: 0.1 wt %.ltoreq.x.ltoreq.20 wt % and 0.1 wt %.ltoreq.y.ltoreq.20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopent. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions.
Increasing Efficiency of Photoelectronic Conversion by Encapsulation of Photosynthetic Reaction Center Proteins in Arrayed Carbon Nanotube Electrode (2008)

The construction of efficient light energy converting (photovoltaic and photoelectronic) devices is a current and great challenge in science and technology and one that will have important economic consequences. Here we show that the efficiency of these devices can be improved by the utilization of a new type of nano-organized material having photosynthetic reaction center proteins encapsulated inside carbon nanotube arrayed electrodes. In this work, a generically engineered bacterial photosynthetic reaction center protein with specifically synthesized organic molecular linkers were encapsulated inside carbon nanotubes and bound to the inner tube walls in unidirectional orientation. The results show that the photosynthetic proteins encapsulated inside carbon nanotubes are photochemically active and exhibit considerable improvement in the rate of electron transfer and the photocurrent density compared to the material constructed from the same components in traditional lamella configuration.
IPv6 Neighbor Discovery Optimizations for Wired and Wireless Networks (2015)

IPv6 Neighbor Discovery (RFC 4861 going back to RFC 1970) was defined
at a time when link-local multicast was as reliable and with the same
network cost (send a packet on a yellow-coax Ethernet) as unicast and
where the hosts were assumed to be always on and connected. Since
1996 we've seen a significant change with both an introduction of
wireless networks and battery operated devices, which poses
significant challenges for the old assumptions. We are also seeing
datacenter networks where virtual machines are not always on and
connected, and scaling of multicast can be challenging. This
specification contains extensions to IPv6 Neighbor Discovery which
remove most use of multicast and make sleeping hosts more efficient.
The specification includes a default mixed mode where a link can have
an arbitrary mix of hosts and/or routers - some implementing legacy
Neighbor Discovery and some implementing the optimizations in this
specification. The optimizations provide incremental benefits to hosts
as soon as the first updated routers are deployed on a link.
Modeling of Bubble Oscillations Induced by a Lithotripter Pulse (2006)

In therapeutic applications of biomedical ultrasound, it is important to understand the behavior of cavitation bubbles. Herein, the dynamics of a single, spherical bubble in water are modeled using the Gilmore equation closed by an energy balance on bubble contents for calculation of pressures inside the bubble. Moreover, heat and mass transfer at the bubble wall are incorporated using the Eller‐Flynn zeroth‐order approximation for gas diffusion, an estimation of non‐equilibrium phase change based on the kinetic theory of gases, and assumed shapes for the spatial temperature distribution in the surrounding liquid. Bubble oscillations predicted by this model are investigated in response to a lithotripter shock wave. Model results indicate that vapor trapped inside the bubble during collapse plays a significant role in the afterbounce behavior and is sensitively dependent upon the ambient liquid temperature. Initial experiments have been conducted to quantify the afterbounce behavior of a single bubble as a function of ambient temperature; however, the results imply that many bubbles are present and collectively determine the collapse characteristics.