gebhart/patrepeval huggingface dataset:
Two-step sintering of Gd_03Lu_16Eu_01O_3 transparent ceramic scintillator (2013)

Transparent ceramic scintillators with the composition Gd0.3Lu1.6Eu0.1O3 (GLO:Eu) have been prepared by different sintering profiles: a traditional profile consisting of a slow ramp followed by a dwell, and a two-step profile consisting of a fast ramp and short dwell followed by a long dwell at a lower temperature. A subsequent Hot Isostatic Press (HIP) step was used to achieve full density and transparency. Two-step sintering allowed full transparency to be achieved after HIPing at 1525°C, while traditionally sintered samples required 1850°C in the HIP to achieve high transparency indicating that two-step sintering is successful in maintaining a small grain size and therefore allowing densification to be decoupled from grain growth during the low temperature HIP step. HIPing at elevated temperatures between 1525 and 1850°C resulted in rapid grain growth from sub-micron to ~300 µm grains. Radioluminescence spectra show negligible difference between samples with sub-micron grain size and those with 300 µm grains.
Laforin preferentially binds the neurotoxic starch-like polyglucosans, which form in its absence in progressive myoclonus epilepsy (2004)

Lafora disease (LD) is a fatal and the most common form of adolescent-onset progressive epilepsy. Fulminant endoplasmic reticulum (ER)-associated depositions of starch-like long-stranded, poorly branched glycogen molecules [known as polyglucosans, which accumulate to form Lafora bodies (LBs)] are seen in neuronal perikarya and dendrites, liver, skeletal muscle and heart. The disease is caused by loss of function of the laforin dual-specificity phosphatase or the malin E3 ubiquitin ligase. Towards understanding the pathogenesis of polyglucosans in LD, we generated a transgenic mouse overexpressing inactivated laforin to trap normal laforin's unknown substrate. The trap was successful and LBs formed in liver, muscle, neuronal perikarya and dendrites. Using immunogold electron microscopy, we show that laforin is found in close proximity to the ER surrounding the polyglucosan accumulations. In neurons, it compartmentalizes to perikaryon and dendrites and not to axons. Importantly, it binds polyglucosans, establishing for the first time a direct association between the disease-defining storage product and disease protein. It preferentially binds polyglucosans over glycogen in vivo and starch over glycogen in vitro, suggesting that laforin's role begins after the appearance of polyglucosans and that the laforin pathway is involved in monitoring for and then preventing the formation of polyglucosans. In addition, we show that the laforin interacting protein, EPM2AIP1, also localizes on the polyglucosan masses, and we confirm laforin's intense binding to LBs in human LD biopsy material.
Site-specific cleavage of duplex DNA with a .lambda. repressor-staphylococcal nuclease hybrid (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-specific cleavage of duplex DNA with a .lambda. repressor-staphylococcal nuclease hybridDehua Pei and Peter G. SchultzCite this: J. Am. Chem. Soc. 1990, 112, 11, 4579–4580Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ja00167a085https://doi.org/10.1021/ja00167a085research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PREFACE (2019)

We are pleased to edit a special issue covering recent advances associated with severe plastic deformation (SPD).The process of SPD has received significant attention as a powerful tool to produce ultrafine-grained structures with enhanced mechanical properties in many metallic materials.Recent studies further demonstrated that the SPD process has high potential in controlling micro-and nanostructures of nonmetallic materials such as ceramics and semiconductors to exhibit unique structural and functional properties.In this special issue, many scientists were invited to submit papers related to the SPD process including studies of microstructures features, analyses of crystal structures, measurements and evaluations of structural and functional properties.Most of the invited papers appeared in the forms of review and overview.This special issue thus provides a wide range of the current status as well as of the historical background for SPD-related researches using experimental and theoretical approaches.Thus far, Materials Transactions published three special issues on the SPD-related subject under the title of Severe Plastic Deformation for Production of Ultrafine Structures and Unusual Mechanical Properties: with subheadings of Investigating Role of High-Density Lattice Defects in 2007, Understanding Mechanisms in 2008, and Aiming Breakthrough in Materials Development in 2009.We have also organized the International Symposium/Workshop on Giant Straining Process for Advanced Materials (GSAM) since 2008.Proceeding books are available for the GSAM Symposium/Workshop in 2010, 2015, 2016, 2017 and 2018.Such GSAM series of meetings have been organized to provide a platform where scientists and engineers dealing not only with SPD but also with various research fields meet to exchange idea and opinion based on up-to-date results on mechanical and functional properties.It should be noted that the GSAM2010 symposium was held, for the first time, for multifunctionality with the title of Production of Multifunctional Materials Using Severe Plastic Deformation.Many authors in this special issue participated in one or more of the GSAM series of the symposium/workshop.We appreciate again their contributions to this special issue.In fact, it turns out that the total of more than 40 papers were submitted to this special issue, which are then 4 times as large as we initially expected.Therefore, the accepted papers are published by splitting into the July and August issues in 2019.Finally, we would like to express our sincere thanks to reviewers for devoting their valuable time to provide very useful and productive comments and advices to improve quality of this special issue.
ChemInform Abstract: NEUTRAL TRIS(O-BENZOQUINONE) COMPLEXES OF CHROMIUM, MOLYBDENUM, AND TUNGSTEN (1974)

Rückflußerhitzen des Chinons (I) mit den Metallcarbonylen (II) in Benzol liefert die diamagnetischen, IR- und elektronenspektroskopisch charakterisierten Tris-Komplexe (III).
40 Gb/s Traveling-Wave Electroabsorption Modulator-Integrated DFB Lasers Fabricated Using Selective Area Growth (2009)

In this paper, we present the fabrication of 40 Gb/s traveling-wave electroabsorption modulator-integrated laser (TW-EML) modules. A selective area growth method is first employed in 40 Gb/s EML fabrication to simultaneously provide active layers for lasers and modulators. The 3 dB bandwidth of a TW-EML module is measured to be 34 GHz, which is wider than that of a lumped EML module. The 40 Gb/s non-return-to-zero eye diagram shows clear openings with an average output power of +0.5 dBm.
Optimal direct path detection for positioning with communication signals in indoor environments (2012)

Recent development in wireless communication-based positioning systems using time-of-arrival (TOA) methods poses a significant challenge for the estimation of signal propagation time in indoor environments. Due to the possible obstruction of the direct path, the signal component from direct propagation can be very weak and therefore, the performance of TOA estimation will be significantly degraded, especially when the received signal experiences severe multipath propagation effects. An optimal direct path detection algorithm using multipath interference cancellation is proposed in this paper to improve the accuracy of communication-based positioning systems. By maximizing the probability of correct identification between the strong interfering paths and noise-only paths, an optimal threshold is derived for interfering multipath component selection. The interference of multipath components is reconstructed and then subtracted from the received signal to enhance the accuracy of direct path detection. The performance of the proposed algorithm is verified by simulations.
Aerodynamically assisted jetting and threading for processing concentrated suspensions containing advanced structural, functional and biological materials (2008)

In recent years material sciences have been interpreted right across the physical and the life sciences. Essentially this discipline broadly addresses the materials, processing, and/or fabrication right up to the structure. The materials and structures areas can range from the micro- to the nanometre scale and, in a materials sense, span from the structural, functional to the most complex, namely biological (living cells). It is generally recognised that the processing or fabrication is fundamental in bridging the materials with their structures. In a global perspective, processing has not only contributed to the materials sciences but its very nature has bridged the physical with the life sciences. In this review we discuss one such swiftly emerging fabrication approach having a plethora of applications spanning the physical and life sciences.
ChemInform Abstract: Titanium‐Substituted Zeolite Beta: An Efficient Catalyst in the Oxy‐Functionalization of Cyclic Alkenes Using Hydrogen Peroxide in Organic Solvents. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Monitoring of Natural Killer Cell Immunotherapy Using Noninvasive Imaging Modalities (2010)

Cancer immunotherapies can be guided by cellular imaging techniques, which can identify the presence or absence of immune cell accumulation in the tumor tissue in vivo and in real time. This review summarizes various new and evolving imaging techniques employed for tracking and monitoring of adoptive natural killer cell immunotherapies.
Managing the Innovation Supply Chain to Maximize Personalized Medicine (2014)

Personalized medicine epitomizes an evolving model of care tailored to the individual patient. This emerging paradigm harnesses radical technological advances to define each patient's molecular characteristics and decipher his or her unique pathophysiological processes. Translated into individualized algorithms, personalized medicine aims to predict, prevent, and cure disease without producing therapeutic adverse events. Although the transformative power of personalized medicine is generally recognized by physicians, patients, and payers, the complexity of translating discoveries into new modalities that transform health care is less appreciated. We often consider the flow of innovation and technology along a continuum of discovery, development, regulation, and application bridging the bench with the bedside. However, this process also can be viewed through a complementary prism, as a necessary supply chain of services and providers, each making essential contributions to the development of the final product to maximize value to consumers. Considering personalized medicine in this context of supply chain management highlights essential points of vulnerability and/or scalability that can ultimately constrain translation of the biological revolution or potentiate it into individualized diagnostics and therapeutics for optimized value creation and delivery.
Ellipsometry study on refractive index profiles of the SiO2/Si3N4/SiO2/Si structure (1993)

In this work, the refractive index profiles of SiO2/Si3N4/SiO2/silicon (ONO) structures were measured and analyzed by ellipsometry. The ONO structures were obtained by oxidizing the Si3N4/SiO2/silicon structure in a wet O2 ambient at the temperature range of 900–1050 °C for different lengths of time. It was found that for a nitride film thickness less than 250 Å, oxygen not only oxidized the surface, but diffused through the nitride and oxidized the inner surface of the nitride. This result was confirmed by the Auger analysis. The kinetics of the wet O2 oxidation of nitride at the above temperature range was linear for an oxidation time of 30–120 min. The activation energy was 2.24 eV.
Collaborative Virtual Screening to Elaborate an Imidazo[1,2-A]pyridine Hit Series for Visceral Leishmaniasis (2020)

An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. Parasitology and early ADME data is presented.
Erratum: Maximum time delay achievable on propagation through a slow-light medium [Phys. Rev. A71, 023801 (2005)] (2005)

We are grateful to Bruno Macke of the University of Lille for calling to our attention several errors in the equations of our paper 1.These errors do not appear in the final results of our calculation nor do they influence the conclusions of our work, but they could present a problem for someone attempting to reproduce the details of our calculation.These errors are as follows.The last term of Eq. 4 should read +f 2 / 2 instead of -f 2 / 2 .Also Eq. 12 should readThree lines below Eq. 13, the in-line equation should read L max =3T 0 2 2 / f 0 .Fourteen lines below Eq. 15, the in-line equation should read T 0 =50/ instead of T 0 =50.Also, a factor of i ba is missing in the numerator of Eq. 16, and the text following this equation should read "where ba is the coherence dephasing rate of the probe transition, s is the Rabi frequency of the strong coupling field which is tuned near the bc transition, is the detuning of the coupling field from exact resonance, and ca is the dephasing rate of the ground state coherence.For a dilute medium the refractivity n -1 and the absorption coefficient are respectively given by 1 2 Re 1 and / cIm 1 ."
Hermansky-Pudlak syndrome and oculocutaneous albinism in Chinese children with pigmentation defects and easy bruising (2019)

Clinical manifestations of oculocutaneous albinism and easy bruisability may be observed in children with HPS or OCA1. Establishing definitive diagnoses in children presenting with these phenotypic features is facilitated by genetic testing. Non-syndromic oculocutaneous albinism and various HPS subtypes, including HPS-4, are found in children of Chinese ancestry.
A Gray Box Conceptual Model for Accountability and Ethics in Business Contracts (2021)

Current computational models are inadequate for the purposes of modeling interactions between autonomous parties in a way that highlights and supports their accountability. We propose a new conceptual model for business contracts based on norms motivated by a review of real-life business contracts. Our conception is of a gray box, reflecting the idea that a contract makes the participants accountable to one another and to outside entities, and therefore calls for the exposure of sufficient implementation details. The model consists of a recursively applicable taxonomy of clause types. In a preliminary study, we found that computer scientists are able to effectively identify the concepts introduced in this model, thereby indicating its potential for building Internet applications that support accountability.
Caring for soil is caring for life : ensure 75% of soils are healthy by 2030 for healthy food, people, nature and climate : interim report of the mission board for soil health and food : study (2020)

Vytauto Didžiojo universitetas / Vytautas Magnus University
Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat. (1987)

Pirenzepine has been widely used for the treatment of gastric and duodenal ulcer. In this work we have proved that this drug could prevent the inflammatory reaction induced in the colon with an intraluminal stimuli as the acetic acid. These data suggest the cholinergic participation in the inflammatory colonic response.
Flux and energy analysis of species in hollow cathode magnetron ionized physical vapor deposition of copper (2010)

To meet the stringent requirements of interconnect metallization for sub-32 nm technologies, an unprecedented level of flux and energy control of film forming species has become necessary to further advance ionized physical vapor deposition technology. Such technology development mandates improvements in methods to quantify the metal ion fraction, the gas∕metal ion ratio, and the associated ion energies in the total ion flux to the substrate. In this work, a novel method combining planar Langmuir probes, quartz crystal microbalance (QCM), and gridded energy analyzer (GEA) custom instrumentation is developed to estimate the plasma density and temperature as well as to measure the metal ion fraction and ion energy. The measurements were conducted in a Novellus Systems, Inc. Hollow Cathode Magnetron (HCM(TM)) physical vapor deposition source used for deposition of Cu seed layer for 65-130 nm technology nodes. The gridded energy analyzer was employed to measure ion flux and ion energy, which was compared to the collocated planar Langmuir probe data. The total ion-to-metal neutral ratio was determined by the QCM combined with GEA. The data collection technique and the corresponding analysis are discussed. The effect of concurrent resputtering during the deposition process on film thickness profile is also discussed.
O2 Binding and Dissociation and Ligand Exchange Reaction of O2 with CO in Polymer Composite Films of Hemoglobin (1997)

A polymer composite film of hemoglobin (Hb–polymer film) was prepared by the casting of an Hb–polymer mixed solution (weight ratio of Hb to polymer is 1 to 1). The percentages of O2 and CO saturation of the Hb–dextran film were 46% and 70%, respectively. In the Hb solution, 100% saturation was observed for both ligands, and a humidified Hb–dextran film also showed 100% saturation. Water molecules would provide flexibility to the matrix polymer and promote a structural change in the Hb from a tense state (T) to a relaxed state (R). Thus the ligand binding to the Hb in the polymer films was strongly affected by the degree of interaction of Hb with the matrix polymers and the physical properties of the polymers. Inositol hexaphosphate (IHP) worked as an allosteric effector even in the solid polymer film and lowered the oxygen affinity of Hb. The O2 transport through an Hb–polyethyleneimine (PEI) film with IHP showed the facilitated O2 transport in comparison with the film without IHP because of the high dissociation rate of O2 from Hb with IHP. © 1997 John Wiley & Sons, Ltd.
Subjective and Objective Quality Assessment of High-Motion Sports Videos at Low-Bitrates (2022)

Videos often have to be transmitted and stored at low bitrates due to poor network connectivity during adaptive bitrate streaming. Designing optimal bitrate ladders that would select the perceptually-optimized resolution, frame-rate, and compression level for low-bitrate videos for adaptive streaming across the internet is therefore a task of great interest. Towards that end, we conducted the first large-scale study of medium and low-bitrate videos from live sports for two codecs (Elemental AVC and HEVC) and created the Amazon Prime Video Low-Bitrate Sports (APV LBS) dataset. The study involved 94 participants and 742 videos, with more than 23,000 human opinion scores collected in total. We analyzed the data obtained and we also conducted an extensive evaluation of objective Video Quality Assessment (VQA) algorithms and benchmarked their performance, and make recommendations on bitrate ladder design. We're making the metadata and VQA features available at https://github.com/JoshuaEbenezer/lbmfr-public.
Retroperitoneal oblique corridor to the L2–S1 intervertebral discs in the lateral position: an anatomic study (2014)

The oblique corridor allows access to the L2-S1 discs while keeping the patient in a lateral decubitus position without a break in the table. Minimal psoas retraction without significant tendon disruption allowed for a generous corridor to the disc space. The L5-S1 disc space can be accessed from an oblique angle consistently with gentle retraction of the iliac vessels. This study supports the potential of an MIS oblique retroperitoneal approach to the L2-S1 discs.
Radioimmunoscintigraphy Using Monoclonal Antibodies before Second-Look Surgery in Patients Suffering from Ovarian Cancer (1987)

19 patients with a known history of ovarian cancer were investigated by radioimmunoscintigraphy (RIS) to look for recurrent disease a few days before second-look surgery. The tumor-associated monoclonal antibody HMFG-2 (400 micrograms/patient) was injected intravenously after labeling with radioactive 123I (0.5-2.2 mCi/patient). Scans were reviewed for activity accumulations due to uptake of the tumor-associated antibody by tumor sites. In 15 out of the 19 cases the scan results correlated with the intraoperative findings. There were 2 false-positive and 2 false-negative scans, the latter in patients with subclinical disease. The smallest lesion detected by radioimmunoscintigraphy had a diameter of 1.5 cm. In 3 patients, tumor sites were identified that had been missed by all other routinely performed methods of investigation including transmission computed tomography. These data indicate that RIS is of considerable clinical value in the early detection and localization of recurrent ovarian cancer and may, therefore, improve the management of these patients.
Theta-1 zeolite catalyst for increasing the yield of propene when cracking olefins and its potential integration with an olefin metathesis unit (2017)

Theta-1 zeolite with secondary mesoporosity improves propene selectivity with respect to ZSM-5 for cracking of olefins.
Supplementary Figure S4 from Clinical Acquired Resistance to RAF Inhibitor Combinations in <i>BRAF</i>-Mutant Colorectal Cancer through MAPK Pathway Alterations (2023)

&lt;p&gt;Supplementary Figure S4. Wild-type KRAS overexpression drives resistance to RAF inhibitor combinations.&lt;/p&gt;