gebhart/patrepeval huggingface dataset:
Automated Optimization for Electric Machines (2017)

The optimized design of electrical machines is a nonlinear multi-objective problem. Electric machine designers today rely on rules of thumb for initial sizing and topology selection. The steps in the process of formulating an optimization problem are as follows: identification of objective functions, selection of the input design variables, and definition of the constraints. This chapter illustrates the two main approaches for systematic design optimization: design of experiments (DOE) and differential evolution. The DOE and response surface (RS) methods are techniques, which are employed for the establishment of a relationship between the inputs and outputs of a system. Each design variable undergoes a mutation, which expands the search space. Multi-objective optimization combined with differential evolution is formulated and employed. A DOE-based approach was initially used to identify the input variables with the most significant effect on the output.
Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives (2020)

The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. This article focuses on recent advancements in conductive materials, with emphasis on overviewing their incorporation with non-conducting polymers to fabricate electroactive wound dressings. The characteristics of these electroactive dressings are deliberated, and the mechanisms on how they accelerate the wound healing process are discussed. Potential directions for the future development of electroactive wound dressings and their potential in monitoring the course of wound healing in vivo concomitantly are also proposed.
PhraseCut: Language-Based Image Segmentation in the Wild (2020)

We consider the problem of segmenting image regions given a natural language phrase, and study it on a novel dataset of 77,262 images and 345,486 phrase-region pairs. Our dataset is collected on top of the Visual Genome dataset and uses the existing annotations to generate a challenging set of referring phrases for which the corresponding regions are manually annotated. Phrases in our dataset correspond to multiple regions and describe a large number of object and stuff categories as well as their attributes such as color, shape, parts, and relationships with other entities in the image. Our experiments show that the scale and diversity of concepts in our dataset poses significant challenges to the existing state-of-the-art. We systematically handle the long-tail nature of these concepts and present a modular approach to combine category, attribute, and relationship cues that outperforms existing approaches.
Analytical Tools for the Characterization of Power Devices (2000)

Since power devices require an electrically active, thick n‐type silicon layer with high resistivity and a large area, their electrical characteristics are extremely sensitive to contamination. If transition metals diffuse into the wafers during the high temperature steps required for device fabrication, an uncontrolled increase in leakage current and on state voltage can be observed. Furthermore, current filamentation and instabilities of the electrical data can occur. As a consequence of the low doping level of the n‐base, the blocking voltage and the failure rate due to cosmic radiation are sensitive to contaminating atoms acting as donors or acceptors. To obtain information about the sources and the extent of the contamination, a contamination check was performed after each high temperature step. Moreover, the dependence of the carrier lifetime on temperature and injection level was analyzed for typical operation conditions of power devices. The results proved to be important in finding ways of keeping contamination and silicon defect densities as low as possible and to ensure that good electrical data with adequate stability could be obtained. © 2000 The Electrochemical Society. All rights reserved.
Acoustic characterization of some commercially available closed cell rubbers and corprene (1987)

Three closed cell and two corprene rubbers (manufactured by Rubatex and Groendyk Corporations, respectively) with Neoprene and nitrile bases have been experimentally investigated in the frequency range of 10 to 70 kHz. These materials contain approximately 50% air and simulate a pressure release surface with reflection coefficients near −0.95. The characterization includes longitudinal sound speed and transmission, reflection, and absorption coefficients as functions of incident angles and frequency. The dynamic (complex) Young's modulus and loss factors have been determined by the longitudinal resonance method. Poisson's ratio is assumed to be 0.499 which allows prediction of the shear modulus. A comparison between the experimentally determined reflection and transmission coefficients with theoretical values [D. L. Folds and C. D. Loggins, J. Acoust. Soc. Am. 62, 1102–1109 (1977)] is presented. Prediction of the moduli using contemporary composite models will also be presented.
Color Correction based on Local Color Correspondences for Stereo Camera Pairs (2011)

Color mismatch between two images can seriously degrade perceptual quality of stereoscopic image. In this paper, a color correction algorithm for a main-sub stereoscopic camera is proposed. An affine color correction function (ACCF) is computed by the 1CP algorithm incorporated with RANSAC. We employ several levels of localities to restrict the range of correspondence search during the iteration. Several experimental results show that the proposed algorithm based on the local color correspondences is useful for color matching between two stereo images.
Evaluation of a new vaccination strategy against Bluetongue based on a group specific antigen (VP7) (2009)

International audience
LARGE-SCALE DISTRIBUTION OF ARRIVAL DIRECTIONS OF COSMIC RAYS DETECTED ABOVE 1018 eV AT THE PIERRE AUGER OBSERVATORY (2012)

ABSTRACT A thorough search for large-scale anisotropies in the distribution of arrival directions of cosmic rays detected above 10 18 eV at the Pierre Auger Observatory is presented. This search is performed as a function of both declination and right ascension in several energy ranges above 10 18 eV, and reported in terms of dipolar and quadrupolar coefficients. Within the systematic uncertainties, no significant deviation from isotropy is revealed. Assuming that any cosmic-ray anisotropy is dominated by dipole and quadrupole moments in this energy range, upper limits on their amplitudes are derived. These upper limits allow us to test the origin of cosmic rays above 10 18 eV from stationary Galactic sources densely distributed in the Galactic disk and predominantly emitting light particles in all directions.
The Letters of Gertrude Stein and Virgil Thomson: Composition as Conversation (2011)

Book Review| November 01 2011 The Letters of Gertrude Stein and Virgil Thomson: Composition as Conversation The Letters of Gertrude Stein and Virgil Thomson: Composition as Conversation. Edited by Susan Holbrook and Thomas Dilworth. New York: Oxford University Press, 2010. ISBN 978-0-19-538663-9. Hardback. Pp. viii, 336. $49.95. Kara Anne Gardner Kara Anne Gardner Search for other works by this author on: This Site Google American Music (2011) 29 (3): 381–383. https://doi.org/10.5406/americanmusic.29.3.0381 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Kara Anne Gardner; The Letters of Gertrude Stein and Virgil Thomson: Composition as Conversation. American Music 1 January 2011; 29 (3): 381–383. doi: https://doi.org/10.5406/americanmusic.29.3.0381 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressAmerican Music Search Advanced Search The text of this article is only available as a PDF. Copyright 2011 by the Board of Trustees of the University of Illinois2011 Article PDF first page preview Close Modal You do not currently have access to this content.
High-dose pulse chlorambucil. Effective therapy for rapid remission induction in nodular lymphocytic poorly differentiated lymphoma (1982)

Eighteen patients with Stage III or IV nodular poorly differentiated lymphocytic lymphoma (malignant lymphoma, infiltrative nodular type, with predominately small cleaved cells) were treated with intermittent high-dose oral chlorambucil (16 mg/m2 daily for five consecutive days each month) for one year. Complete clinical remissions occurred in 78% of these patients and partial remissions in another 17%. Complete remission usually occurred within three months of beginning therapy and with a medial follow-up of 35 months no patient has relapsed. Toxicity, usually hematologic and occurring late in therapy, has been mild, necessitating termination of therapy in only one patient. Review of recent therapy fails to demonstrate a definite long-term advantage of more aggressive treatment regimens. Intermittent high-dose chlorambucil should be further evaluated as therapy for nodular poorly differentiated lymphocytic lymphoma.
Fibre optic gyroscopes for space use (2017)

Among the technologies available for gyroscopes usable in space, the Fibre Optic Gyroscope (FOG) technology appears to be the most suitable: no moving parts, very good lifetime, low power consumption, very low random walk, arbitrarily low angular resolution and very good behaviour in radiations and vacuum. Benefiting from more than ten years of experience with this technology, Ixsea (formerly the Navigation Division of Photonetics) is developing space FOG under both CNES and ESA contracts since many years. In the 1996-1998 period, two space FOG demonstrators in the 0,01&deg;/h class were manufactured, including an optical head (optic and optoelectronic part) designed for space use and a standard ground electronics. Beyond the demonstration of the specified FOG performances, the behaviour of the optical head has been validated for use in typical space environment: vibrations, shocks, radiations (up to 50 krad) and thermal vacuum. Since the beginning of 1999, Ixsea is developing a space electronics in order to manufacture two complete space FOG. The first one entered in qualification in October. The second one will be delivered beginning of next year, it will be used in a CNES attitude measurement experiment (MAGI) onboard the FrenchBrazilian Microsatellite (FBM) partly dedicated to technology evaluation.
CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17 (2020)

Accumulation of CD103<sup>+</sup>CD8<sup>+</sup> resident memory T (T<sub>RM</sub>) cells in human lung tumors has been associated with a favorable prognosis. However, the contribution of T<sub>RM</sub> to anti-tumor immunity and to the response to immune checkpoint blockade has not been clearly established. Using quantitative multiplex immunofluorescence on cohorts of non-small cell lung cancer patients treated with anti-PD-(L)1, we show that an increased density of CD103<sup>+</sup>CD8<sup>+</sup> lymphocytes in immunotherapy-naive tumors is associated with greatly improved outcomes. The density of CD103<sup>+</sup>CD8<sup>+</sup> cells increases during immunotherapy in most responder, but not in non-responder, patients. CD103<sup>+</sup>CD8<sup>+</sup> cells co-express CD49a and CD69 and display a molecular profile characterized by the expression of PD-1 and CD39. CD103<sup>+</sup>CD8<sup>+</sup> tumor T<sub>RM</sub>, but not CD103<sup>-</sup>CD8<sup>+</sup> tumor-infiltrating counterparts, express Aiolos, phosphorylated STAT-3, and IL-17; demonstrate enhanced proliferation and cytotoxicity toward autologous cancer cells; and frequently display oligoclonal expansion of TCR-β clonotypes. These results explain why CD103<sup>+</sup>CD8<sup>+</sup> T<sub>RM</sub> are associated with better outcomes in anti-PD-(L)1-treated patients.
Association analyses between brain‐expressed fatty‐acid binding protein (FABP) genes and schizophrenia and bipolar disorder (2009)

Deficits in prepulse inhibition (PPI) are a biological marker for psychiatric illnesses such as schizophrenia and bipolar disorder. To unravel PPI-controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene. In that study, human FABP7 showed genetic association with schizophrenia. FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain. These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and docosahexaenoic acids. Additionally, the involvement of PUFAs has been documented in the pathophysiology of schizophrenia and mood disorders. Therefore in this study, we examined the genetic roles of FABP5 and 3 in schizophrenia (N = 1,900 in combination with controls) and FABP7, 5, and 3 in bipolar disorder (N = 1,762 in the case-control set). Three single nucleotide polymorphisms (SNPs) from FABP7 showed nominal association with bipolar disorder, and haplotypes of the same gene showed empirical associations with bipolar disorder even after correction of multiple testing. We could not perform association studies on FABP5, due to the lack of informative SNPs. FABP3 displayed no association with either disease. Each FABP is relatively small and it is assumed that there are multiple regulatory elements that control gene expression. Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses.
Integrating microelectromechanical systems with integrated circuits (2004)

From the very beginning, integration of microelectromechanical systems (MEMS) with integrated circuits (ICs) was a major attraction of silicon micromachining technology. Significant progress toward integrating MEMS with ICs technologies has been made over the last four decades. Many products have been introduced and the benefits of such integration have been demonstrated. One of the most attractive developments, during the period of time called the Optical Bubble, was the vertical MEMS-IC integration, pioneered by Transparent Networks. It enabled a short path to merging VLSI electronics with MEMS. This approach can be easily applied to capacitive sensors, such as pressure, acceleration, gyro, and vacuum sensors, as well as to a broad range of other products.
Bone Marrow-Derived lin−c-kit+Sca-1+ Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma (2005)

The development of tumor vasculature is thought to occur through two complementary processes: sprouting angiogenesis from preexisting blood vessels of the host, and vasculogenesis, which involves the spontaneous development of vessels through specific recruitment, differentiation, and vascular incorporation of circulating endothelial cells (EC), endothelial progenitor cells (EPC), or potentially bone marrow-derived cells. Recent reports, however, have challenged the belief that bone marrow-derived cells contribute to tumor neovascularization, claiming an exclusive role for sprouting angiogenesis in tumor blood vessel development. In the present study, we explored the recruitment behavior of bone marrow-derived lin(-)c-kit(+)Sca-1+ stem cells to subcutaneously implanted Lewis lung carcinoma in a syngeneic bone marrow transplantation model. We observed that although lin(-)c-kit(+)Sca-1+ and their derived cells demonstrate significant recruitment to carcinomas in vivo, they do not appear to functionally contribute to tumor neovascularization. Furthermore, our results support the hypothesis that new vessel formation in carcinomas occurs primarily through endothelialization from adjacent and preexisting vasculature.
A Comparison of Single Molecule and Amplification Based Sequencing of Cancer Transcriptomes (2011)

The second wave of next generation sequencing technologies, referred to as single-molecule sequencing (SMS), carries the promise of profiling samples directly without employing polymerase chain reaction steps used by amplification-based sequencing (AS) methods. To examine the merits of both technologies, we examine mRNA sequencing results from single-molecule and amplification-based sequencing in a set of human cancer cell lines and tissues. We observe a characteristic coverage bias towards high abundance transcripts in amplification-based sequencing. A larger fraction of AS reads cover highly expressed genes, such as those associated with translational processes and housekeeping genes, resulting in relatively lower coverage of genes at low and mid-level abundance. In contrast, the coverage of high abundance transcripts plateaus off using SMS. Consequently, SMS is able to sequence lower- abundance transcripts more thoroughly, including some that are undetected by AS methods; however, these include many more mapping artifacts. A better understanding of the technical and analytical factors introducing platform specific biases in high throughput transcriptome sequencing applications will be critical in cross platform meta-analytic studies.
The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism (2011)

Genetic impairment of the genes coding for three mammalian trefoil peptides resulted in severe gastrointestinal malfunctions. The trefoil peptides also appear involved in caloric metabolism. Monitoring global miRNA expression of Tff3 deficient mice points to an interplay of Tff3 with a miRNA regulatory network. We identified 21 miRNAs that were deregulated when compared to the wild type strain. In silico evaluation indicated that the majority of the 21 miRNA were connected with the metabolic pathway "glycolysis/gluconeogenesis'' (p=0.032), a signaling pathway including nine target genes Aldh9a1, Aldh2, Pck1, Aldoc, Pgam2, Pck2, Adh4, Adh5, and Fbp1. Association of Tff3 with this metabolic pathway is further supported by the observation that the body mass of adult Tff3 KO mice (five months) showed a clearly reduced weight. Furthermore, the majority of the identified 21 miRNA genes are localized on murine chromosomes 2 and 5 in three clusters (2A1, 2B, 5B3) suggesting a coordinated expression control and function.
Full utilisation, dynamic fairness, and bounded access delay on high speed slotted bus networks (2002)

High speed slotted bus networks are attractive candidates for MANs, backbone networks for LANs, high speed access networks, and feeder networks for high speed ATM networks. In all of these approaches, there are tradeoffs between utilization, fairness, access delay, overhead, and complexity. Our objective here is to understand the relationship between utilization, fairness, and access queueing delay. The paper extends the FUFA protocol (Chiu and Gallager) to the FUFAet protocol.
IRON (III) PERCHLORATE DOPING OF POLYACETYLENE (1983)

Free standing films of polyacetylene have been oxidized with Fe (ClO4)3 to yield materials exhibiting high electrical conductivity thus providing an alternative route to the electrochemical p-doping with perchlorate anion.
Tumor Necrosis Factor Induces Hyperphosphorylation of Kinesin Light Chain and Inhibits Kinesin-Mediated Transport of Mitochondria (2000)

The molecular motor kinesin is an ATPase that mediates plus end-directed transport of organelles along microtubules. Although the biochemical properties of kinesin are extensively studied, conclusive data on regulation of kinesin-mediated transport are largely lacking. Previously, we showed that the proinflammatory cytokine tumor necrosis factor induces perinuclear clustering of mitochondria. Here, we show that tumor necrosis factor impairs kinesin motor activity and hyperphosphorylates kinesin light chain through activation of two putative kinesin light chain kinases. Inactivation of kinesin, hyperphosphorylation of kinesin light chain, and perinuclear clustering of mitochondria exhibit the same p38 mitogen-activated kinase dependence, indicating their functional relationship. These data provide evidence for direct regulation of kinesin-mediated organelle transport by extracellular stimuli via cytokine receptor signaling pathways.
Assessment on Tolerance Representation and Tolerance Analysis in Assemblies (2000)

Due to the difficulty of modeling the manufacturing deviations reliably, the existing geometric models, to date, have only considered the exact description of parts and assemblies. Yet, the tolerance representation and propagation issues in assemblies are crucial to answer parallel design of product and process queries. Many formal and informal methods have been developed. However, most proved special cases of the ANSI Y14.5M-82 specification standard. Also, the descriptions provided in actual solid and feature based design modelers are inadequate to ascertain a clear taxonomy of tolerance specifications, neither do they help address the assembly tolerance analysis and/or synthesis issues. The paper purposes to discuss the tolerance representation schemes as well as their underlying philosophies. Then, because tolerance analysis and tolerance synthesis in assemblies are required, among other tasks, to assign functional tolerances, measure the manufacturability and the interchangeability of parts in assemblies, ease tolerance inspection and evaluate costs of alternative assembly sequences, we shall assess deterministic and statistical methods.
ChemInform Abstract: Carbonyl Methylenation of Easily Enolizable Ketones. (1986)

Abstract Das Keton (I) reagiert mit einem metallorganischen Reagens aus CH2I2, Zink und TiCl 4 unter Methylenierung zum Olefin (II) sowie ggfs.
Transport optimal pour la reconstruction robuste de formes à partir de nuages de points (2013)

National audience
Himbacine-Derived Thrombin Receptor Antagonists: C7-Aminomethyl and C9a-Hydroxy Analogues of Vorapaxar (2013)

We have synthesized several C7-aminomethyl analogues of vorapaxar that are potent PAR-1 antagonists. Many of these analogues showed excellent in vitro binding affinity and pharmacokinetics profile in rats. Compound 6a from this series showed excellent PAR-1 activity (K i = 5 nM). We have also synthesized a C9a-hydroxy analogue of vorapaxar, which showed very good PAR-1 affinity (K i = 19.5 nM) along with excellent rat pharmacokinetic profile and ex vivo efficacy in the cynomolgus monkey.