gebhart/patrepeval huggingface dataset:
The effect of mildronate and related substances on levels of thyroid hormones and some intermediates of lipid and carbohydrate metabolism in hyperthyroid and hypothyroid rats (2008)

We have investigated effects of Mildronate, gamma-butyrobetaine (GBB) and their combination ("Neomildronate") on the plasma levels of thyroid gland hormones and some intermediates of basal metabolism (free fatty acids, triglycerides, glucose) in rats with different dysfunctions of thyroid gland, including idiopathic hyperfunction and hypofunction induced by propylthiouracil or L-carnitin administration. Histological investigation of the thyroid gland was also performed. Intraperitoneal injections of Mildronate (150 mg/kg) during 20 days to Wistar male rats with elevated level of thyroid hormones and basal metabolism normalized thyroxine level and parameters of lipid metabolism. Mildronate, GBB and their combination did not affect the natural resurgence of rats with experimental hypofunction induced by propylthiouracil or L-carnitin administration. The possible biochemical role of given treatment in regulation of thyroid gland function is discussed.
Anti-inflammatory potential of peat moss extracts in lipopolysaccharide-stimulated RAW 264.7 macrophages (2014)

The aim of the present study was to identify the anti-inflammatory and anti-oxidative effects of peat moss aqueous extract (PME) on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. To demonstrate the anti-inflammatory and antioxidant effects of PME, the levels of nitric oxide (NO) and cytokines were measured using Griess reagent and cytokine ELISA kits, respectively. Reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analysis were conducted to evaluate the expression of genes and proteins. Immunofluorescence was used to measure the expression and translocation of transcription factors. Pre-treatment with PME inhibited the production of prostaglandin E(2) and NO by suppressing the gene expression of cyclooxygenase-2 and inducible NO synthase, respectively. The LPS-stimulated gene expression and the production of tumor necrosis factor-α and interleukin-1β were significantly reduced by PME. In the LPS-stimulated RAW 264.7 cells, nuclear factor‑κB (NF-κB) translocated from the cytosol to the nucleus, while pre-treatment with PME induced the sequestration of NF-κB in the cytosol through the inhibition of IκBα degradation. In the same manner, PME contributed to the inhibition of the activation of mitogen-activated protein kinases. In addition, the PME-treated RAW 264.7 cells facilitated the activation of nuclear factor-like 2 (Nrf2) , and in turn, enhanced heme oxygenase-1 (HO-1) expression. These results indicate that PME exerts anti-inflammatory and antioxidant effects, and suggest that PME may neutralize inflammation and prevent cellular damage by oxidative stress.
Percutaneous nephrolithotomy. An approach to branched and staghorn renal calculi (1983)

Using electrohydraulic lithotripsy, we removed branched or staghorn calculi from four patients via a percutaneous nephrostomy tract with local anesthesia. There were no serious complications, and the patients were able to resume their preadmission activities immediately after discharge from the hospital. Our experience suggests that, eventually, all upper urinary tract calculi may be treatable by a percutaneous approach.
High crystalline quality single crystal CVD diamond (2009)

Homoepitaxial chemical vapour deposition (CVD) on high pressure high temperature (HPHT) synthetic diamond substrates allows production of diamond material with controlled point defect content. In order to minimize the extended defect content, however, it is necessary to minimize the number of substrate extended defects that reach the initial growth surface and the nucleation of dislocations at the interface between the CVD layer and its substrate. X-ray topography has indicated that when type IIa HPHT synthetic substrates are used the density of dislocations nucleating at the interface can be less than 400 cm-2. X-ray topography, photoluminescence imaging and birefringence microscopy of HPHT grown synthetic type IIa diamond clearly show that the extended defect content is growth sector dependent. &lt;111&gt; sectors contain the highest concentration of both stacking faults and dislocations but &lt;100&gt; sectors are relatively free of both. It has been shown that HPHT treatment of such material can significantly reduce the area of stacking faults and cause dislocations to move. This knowledge, coupled with an understanding of how growth sectors develop during HPHT synthesis, has been used to guide selection and processing of substrates suitable for CVD synthesis of material with high crystalline perfection and controlled point defect content.
Measurements of spin correlation in top-antitop quark events from proton-proton collisions ats=7  TeVusing the ATLAS detector (2014)

Measurements of spin correlation in top quark pair production are presented using data collected with the ATLAS detector at the LHC with proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of $4.6\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$. Events are selected in final states with two charged leptons and at least two jets and in final states with one charged lepton and at least four jets. Four different observables sensitive to different properties of the top quark pair production mechanism are used to extract the correlation between the top and antitop quark spins. Some of these observables are measured for the first time. The measurements are in good agreement with the Standard Model prediction at next-to-leading-order accuracy.
P. falciparum Isolate-Specific Distinct Patterns of Induced Apoptosis in Pulmonary and Brain Endothelial Cells (2014)

The factors implicated in the transition from uncomplicated to severe clinical malaria such as pulmonary oedema and cerebral malaria remain unclear. It is known that alterations in vascular integrity due to endothelial cell (EC) activation and death occur during severe malaria. In this study, we assessed the ability of different P. falciparum clinical isolates to induce apoptosis in ECs derived from human lung and brain. We observed that induction of EC apoptosis was sensitive to the environmental pH and required direct contact between the parasite and the cell, though it was not correlated to the ability of the parasite to cytoadhere. Moreover, the extent of induced apoptosis in the two EC types varied with the isolate. Analysis of parasite genes transcript led us to propose that the activation of different pathways, such as Plasmodium apoptosis-linked pathogenicity factors (PALPF), PALPF-2, PALPF-5 and PF11_0521, could be implied in EC death. These observations provide an experimental framework to decipher the molecular mechanism implicated in the genesis of severe malaria.
ChemInform Abstract: Pd‐Catalyzed Nucleophilic Fluorination of Aryl Bromides. (2014)

Abstract The explored fluorination reaction is applicable to a wide scope of aryl and heteroaryl bromides and iodides to give high yields and proceeds without significant formation of side products.
Towards 3D-Printed Inverse-Designed Metaoptics (2021)

Optical metasurfaces have been heralded as the platform to integrate multiple functionalities in a compact form-factor, potentially replacing bulky components. A central stepping stone towards realizing this promise is the demonstration of multifunctionality under several constraints (e.g. at multiple incident wavelengths and/or angles) in a single device -- an achievement being hampered by design limitations inherent to single-layer planar geometries. Here, we propose a general framework for the inverse design of volumetric 3D metaoptics via topology optimization, showing that even few-wavelength thick devices can achieve high-efficiency multifunctionality. We embody our framework in multiple closely-spaced patterned layers of a low-index polymer. We experimentally demonstrate our approach with an inverse-designed 3d-printed light concentrator working at five different non-paraxial angles of incidence. Our framework paves the way towards realizing multifunctional ultra-compact 3D nanophotonic devices.
A novel function for proSAAS as an amyloid anti‐aggregant in Alzheimer's disease (2013)

Neurodegenerative diseases such as Alzheimer's disease (AD) are characterized by an abnormal aggregation of misfolded beta-sheet rich proteins such as β-amyloid (Aβ). Various ubiquitously expressed molecular chaperones control the correct folding of cellular proteins and prevent the accumulation of harmful species. We here describe a novel anti-aggregant chaperone function for the neuroendocrine protein proSAAS, an abundant secretory polypeptide that is widely expressed within neural and endocrine tissues and which has previously been associated with neurodegenerative disease in various proteomics studies. In the brains of 12-month-old APdE9 mice, and in the cortex of a human AD-affected brain, proSAAS immunoreactivity was highly colocalized with amyloid pathology. Immunoreactive proSAAS co-immunoprecipitated with Aβ immunoreactivity in lysates from APdE9 mouse brains. In vitro, proSAAS efficiently prevented the fibrillation of Aβ(1-42) at molar ratios of 1 : 10, and this anti-aggregation effect was dose dependent. Structure-function studies showed that residues 97-180 were sufficient for the anti-aggregation function against Aβ. Finally, inclusion of recombinant proSAAS in the medium of Neuro2a cells, as well as lentiviral-mediated proSAAS over-expression, blocked the neurocytotoxic effect of Aβ(1-42) in Neuro2a cells. Taken together, our results suggest that proSAAS may play a role in Alzheimer's disease pathology.
ChemInform Abstract: New Macrocycles of Carbon, Nitrogen and Sulfur Atoms Incorporating 4,5‐ Dithio‐1,3‐dithiole‐2‐thione Units. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-power blue/violet QPM-SHG laser using a new ridge-type waveguide (2001)

Summary form only given. Compact blue/violet light sources with high-power, low-noise and diffraction-limited focusing beam are required to realize high-density optical disk systems. A second-harmonic generation (SHG) laser has advantages principally in the noise and beam quality compared with another candidate, the GaN laser. The quasi-phasematched (QPM) SHG device is usually fabricated by forming a proton-exchanged waveguide on a periodically domain-inverted MgO:LiNbO/sub 3/ substrate. However, the proton-exchanged waveguide presents disadvantages such as a graded index profile, asymmetric modes and degraded nonlinear property. Therefore, a new waveguide technology to replace the proton-exchange method is desired to realize efficient and high-power SHG lasers. We focus on the machining technique for processing three-dimensional waveguides which can draw out the original performance of nonlinear crystals. We propose a new ridge-type waveguide QPM-SHG device fabricated by ultraprecision, machining, and demonstrate high-power blue/violet light generation of 100 mW using the Ti:Al/sub 2/O/sub 3/ laser as a fundamental source and 14 mW output by frequency doubling of the laser diode (LD).
Intradialytic hypertension is associated with low intradialytic arterial oxygen saturation (2017)

We observed an inverse relationship between intradialytic SaO2 and the blood pressure response to HD. These findings support the notion that hypoxemia activates mechanisms that partially blunt the intradialytic blood pressure decline, possibly by sympathetic activation and endothelin-1 secretion. To further explore that hypothesis, specifically designed prospective studies are required.
All-fibre, 2ps Yb laser with 60kW peak power (2004)

We demonstrate 2-20ps fibre laser in Yb-wavelength range with up to 60kW peak and 9W average powers. Pulses from a self-starting, ring-fibre-cavity Yb laser with spectral gain/pulse-duration control were amplified in 2m-long, Yb-doped fiber.
On the Utility of 3D Printing for the Design of Meanderline Polarizers (2021)

To achieve circular polarization (CP) from a linearly polarized (LP) antenna, we typically use polarizers. These structures, often referred to as circular polarizers, use layers of printed highly conducting meandered lines separated by dielectric spacers [1]. The latter are often chosen to be lightweight, low permittivity foam, for example Rohacell. As an extension of this concept, discussed herein is the replacement of homogenous commercial off-the-shelf foam spacers with a dielectric lattice. This structure is fabricated using 3D printing, resulting in lower lead times, lower costs, and increased customizability. In this work, we integrate a meanderline polarizer (MLP) with a planar inverted-F antenna (PIFA) unit-cell using artificial 3D printed dielectric.
A Measurement-Based Method for Improving Data Center Energy Efficiency (2008)

In this paper we discuss a novel sensing and measurement technology which allows visualizing the 3D temperature and heat distributions in a data center or other complex thermal system. Specifically, we leverage the high spatial resolution of IBM's mobile measurement technology (MMT). We show that substantially improvements in energy efficiency can be obtained by the MMT method.
Active Electrode Arrays by Chip Embedding in a Flexible Silicone Carrier (2006)

Future cochlear implants demand a higher density of stimulation sites (electrodes) and enhanced functionality (e.g. feedback information). The current generation of implanted cochlear prostheses is making use of a completely "passive scheme" and cannot meet these requirements. An "all-silicon" concept integrating active components with passive electrodes in silicon has been proposed but does not offer the flexibility/stretchability of current silicone-based devices. This paper introduces a novel concept based on silicon chip embedding in a flexible silicone carrier. The process and experimental results will be presented. The concept is also applicable to other types of implanted electrodes, e.g. retinal implants
Sequence-Agnostic Multi-Object Navigation (2023)

The Multi-Object Navigation (MultiON) task requires a robot to localize an instance (each) of multiple object classes. It is a fundamental task for an assistive robot in a home or a factory. Existing methods for MultiON have viewed this as a direct extension of Object Navigation (ON), the task of localising an instance of one object class, and are pre-sequenced, i.e., the sequence in which the object classes are to be explored is provided in advance. This is a strong limitation in practical applications characterized by dynamic changes. This paper describes a deep reinforcement learning framework for sequence-agnostic MultiON based on an actor-critic architecture and a suitable reward specification. Our framework leverages past experiences and seeks to reward progress toward individual as well as multiple target object classes. We use photo-realistic scenes from the Gibson benchmark dataset in the AI Habitat 3D simulation environment to experimentally show that our method performs better than a pre-sequenced approach and a state of the art ON method extended to MultiON.
Two-dimensional object modelling for robotic vision (2003)

The authors define modeling requirements for robotic vision, describe previous work in developing models, and discuss how models are used in vision processing. They describe how Honeywell research results improve on previous manual techniques by using heuristic model feature selection and reduce the need for train-by-showing images by substituting synthetic imagery. Particular, attention is given to efforts to construct an automated modeling system which develops 2-D part recognition models without the use of the online vision system and which requires only minimal operator expertise. The focus has been on two key components of this automated model building system; automated feature selection and ranking, and synthetic image generation. The value of these advances is discussed, along with an assessment of future research needs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol) (2008)

We report a catalytic approach to the synthesis of a key intermediate on the synthetic route to a pharmaceutical drug candidate in single enantiomer form. In particular, we illustrate the discovery process employed to arrive at a powerful, peptide-based asymmetric acylation catalyst. The substrate this catalyst modifies represents a remarkable case of desymmetrization, wherein the enantiotopic groups are separated by nearly a full nanometer, and the distance between the reactive site and the pro-stereogenic element is nearly 6 A. Differentiation of enantiotopic sites within molecules that are removed from the prochiral centers by long distances presents special challenges to the field of asymmetric catalysis. As the distance between enantiotopic sites increases within a substrate, so too may the requirements for size and complexity of the catalyst. The approach presented herein contrasts enzymatic catalysts and small-molecule catalysts for this challenge. Ultimately, we report here a synthetic, miniaturized enzyme mimic that catalyzes a desymmetrization reaction over a substantial distance. In addition, studies relevant to mechanism are presented, including (a) the delineation of structure-selectivity relationships through the use of substrate analogs, (b) NMR experiments documenting catalyst-substrate interactions, and (c) the use of isotopically labeled substrates to illustrate unequivocally an asymmetric catalyst-substrate binding event.
Proton magnetic resonance study of some tetraimine complexes of nickel (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton magnetic resonance study of some tetraimine complexes of nickelVirgil L. Goedken and Daryle H. BuschCite this: Inorg. Chem. 1971, 10, 12, 2679–2682Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ic50106a010https://doi.org/10.1021/ic50106a010research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Metastable entangled states of atomic systems in macroscale: radiation dynamics and spectrum</title> (2004)

Dynamics of spontaneous decay and corresponding emission spectrum areexactly treated for a system of two identical two-level atoms in 1D.Just a one-dimensional case is considered in order to maximally extractan information on mutual influence of spatially remote atoms through theradiation field. As a result, an effect is revealed and considered indetail that there exist stable (metastable) entangled states at definitedistances between the atoms. That state is supported by a(quasi)stationary field bounded between the atoms. Also, acorrespondence is established between the lifetime and emissionspectrum, and possibilities for observing the effect are discussed.
Hafnium interdiffusion studies from hafnium silicate into silicon (2001)

The interdiffusion of Hf and Si from high-κ gate dielectric candidate (HfO2)1−x(SiO2)x thin films deposited on Si (100) was studied using x-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, high resolution transmission electron microscopy, and Rutherford backscattering spectrometry in combination with chemical etching. After extreme rapid and conventional furnace thermal annealing treatments, Hf incorporation into Si is limited to less than 0.5–1 nm from the interface. Implications for high-κ gate dielectric applications are also discussed.
Molecular insights into breast cancer from transgenic mouse models (1991)

We desperately need to know more of the biological details of the onset and progression of breast cancer. The disease is of startlingly high incidence (approaching 1 in 9 women), our current therapies for the disease are inadequate once it has metastasized, and the disease is characterized by excessive morbidity and mortality. Most of the growth and differentiation of the mammary gland occurs relatively late in life: during sexual maturation, and then cyclically during pregnancy and lactation. Normal as well as malignant growth is regulated by endocrine hormones as well as by local tissue factors, such as polypeptide growth factors. Cancer seems to progress as hyperplastic ductal or lobular epithelial growth, acquiring progressive genetic changes (including those of oncogenes and tumor suppressor genes) leading to clonal outgrowths of progressively more malignant cells. The nature of proliferative controls and the relevant genetic changes are the subjects of the current review.
Effect of the Amount of Pt Loading on the Oxygen Storage Capacity of Ceria-Zirconia Solid Solution (2004)

Ceria-zirconia (Ce-Zr) solid solution is widely used as an oxygen storage material, which is a key component in the automotive three-way catalysts. The Ce-Zr solid solution is usually used with noble metals supported on their surface. Thus the evaluation of oxygen storage capacity (OSC) should be conducted on the Ce-Zr solid solution loaded with a noble metal. The measured OSC of noble-metal-loaded Ce-Zr solid solution consists of two parts; one is the stored oxygen within the solid solution itself, and the other is the adsorbed oxygen on the surface of the supported noble metal particles. Therefore, it is necessary to clarify the influence of the noble metal on the measured OSC, and this will also help to ascertain the exact OSC of the solid solution itself. In this research, the authors tried to clarify the above issues by characterizing the OSC performance on Ce-Zr solid solutions with Pt loading from 0.0001 to 10 wt%. We found that, increasing the Pt loading makes the oxygen storage and release rate higher. Temperature increase also makes the oxygen storage rate higher, however, the oxygen release rate is not affected by the temperature. The apparent OSC saturated above a certain level of Pt loading and temperature. The saturated OSC increased with increasing temperature.
Prostate-Specific Antigen Bounce Following Stereotactic Body Radiation Therapy for Prostate Cancer (2014)

PSA bounce, which has been reported after prostate brachytherapy, is also seen in a significant percentage of patients after CyberKnife SBRT. Close observation rather than biopsy can be considered for these patients. Younger age was the only factor that predicted PSA bounce.