gebhart/patrepeval huggingface dataset:
Phase III, randomized, open-label study of triweekly versus biweekly docetaxel (T) as a treatment for advanced hormone-refractory prostate cancer (HRPC): Final analysis of the Finnish Uro-oncological Group Study 1-2003. (2011)

4527 Background: T administered at 3-week intervals is standard treatment for advanced HRPC. We compared 2-weekly to 3-weekly T as first-line chemotherapy of advanced HRPC (prior estramustine phosphate allowed). Methods: 361 pts were entered in this prospective, randomized multicenter trial from March 2004 to May 2009. 346 pts were eligible and received at least one T cycle. The pts were centrally randomly assigned to receive T i.v. either 75 mg/m² d1 q3 wks (tT) or 50 mg/m² d1 and d 14, q4 wks (bT). Prednisolon 10 mg/d was administered orally in both groups. The groups were well balanced with the WHO performance status, mean age (69.3 yrs, range 45-87 yrs vs. 68 yrs, range, 46-85 yrs), and the median serum PSA content at study entry (108.5 µg/L, range 11-1230 vs. 116 µg/L, range 12-1870, respectively). The primary end point was time to treatment failure (TTTF). The planned sample size was 348 pts (α 0.05, 1-ß 0.80, 2-sided log-rank test). Study identifier: NCT00255606. Results: The 346 eligible pts who received at least one dose of docetaxel (tT, 176; bT, 170) are included in the analysis. 1249 and 1051 T cycles were administered in the tT and bT groups, respectively. Serious adverse events were reported more often with the 3-weekly schedule (5.9 vs. 9.4 % of cycles, p=0.002). The median TTTF was longer in the bT group compared to tT (5.6 vs. 4.9 mos, respectively; p=0.016). PSA response was equally frequent in both groups (CR+PR 23%; SD 46%). Overall survival did not differ significantly between the 2 groups (median, 11.2 vs. 11.8 mos, respectively, p=0.164). Conclusions: T administered every 2 weeks was better tolerated than 3-weekly administration and resulted in a longer TTTF, but did not improve survival.
Using perception to plan incremental adaptations (2002)

A robot system operating in an environment in which there is uncertainty and change needs to combine the ability to react with the ability to plan ahead. In a previous paper we proposed a solution to the problems of integrating planning and reaction: cast planning as adaptation of a reactive system. The planner, asynchronously tuning the reactor, decides on the appropriate parts of the reactor to be modified based on perceptions: information gathered in the reactor for the express purpose to inform the planner. In this paper, we show the benefits of using perception to adapt the reactor where it needs to be updated most and present our first experimental results from the planner-reactor architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins (2017)

Among nucleic acid-based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly, high protein levels can be produced from even minute amounts of transfected templates. However, it is an obstacle to full exploitation of this platform that saRNA induces a strong innate host immune response. In transfected cells, pattern recognition receptors sense double-stranded RNA intermediates and via activation of protein kinase R (PKR) and interferon signaling initiate host defense measures including a translational shutdown. To reduce pattern recognition receptor stimulation and unleash suppressed saRNA translation, this study co-delivered non-replicating mRNA encoding vaccinia virus immune evasion proteins E3, K3, and B18. It was shown that E3 is far superior to K3 or B18 as a highly potent blocker of PKR activation and of interferon (IFN)-β upregulation. B18, in contrast, is superior in controlling OAS1, a key IFN-inducible gene involved in viral RNA degradation. By combining all three vaccinia proteins, the study achieved significant suppression of PKR and IFN pathway activation in vitro and enhanced expression of saRNA-encoded genes of interest both in vitro and in vivo. This approach promises to overcome key hurdles of saRNA gene delivery. Its application may improve the bioavailability of the encoded protein, and reduce the effective dose and correspondingly the cost of goods of manufacture in the various fields where saRNA utilization is envisioned.
ChemInform Abstract: Straightforward Synthesis of N‐Protected Benzylic Amines by Carbamoalkylation of Aromatic Compounds. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of α-methyldeoxybenzoins (1999)

Reduction of hydroxy and/or methoxy-substituted isoflavones using LiAlH4 in refluxing THF provides an easy access to a number of α-methyldeoxybenzoins, possible metabolites of phytoestrogens in man. The synthesis of O-demethylangolensin 2b, 6′-hydroxyangolensin 2c, angolensin 2d, 1-(2,4-dihydroxyphenyl)-2-phenylpropan-1-one 2e, 1-(2-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)propan-1-one 2f, 4′-O-methylangolensin 2g, 1-(2-hydroxy-4-methoxyphenyl)-2-phenylpropan-1-one 2h, and 1-(2-hydroxyphenyl)-2-phenylpropan-1-one 2i is described.
Aryl Ether Dendrimers with an Interior Metalloporphyrin Functionality as a Spectroscopic Probe:  Interpenetrating Interaction with Dendritic Imidazoles (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTAryl Ether Dendrimers with an Interior Metalloporphyrin Functionality as a Spectroscopic Probe: Interpenetrating Interaction with Dendritic ImidazolesYoriko Tomoyose, Dong-Lin Jiang, Ren-Hua Jin, Takuzo Aida, Takashi Yamashita, Kazuyuki Horie, Eiji Yashima, and Yoshio OkamotoView Author Information Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan Department of Applied Chemistry, Faculty of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-01, JapanCite this: Macromolecules 1996, 29, 15, 5236–5238Publication Date (Web):July 15, 1996Publication History Received17 April 1996Revised14 May 1996Published online15 July 1996Published inissue 1 January 1996https://doi.org/10.1021/ma960575+Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views858Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (157 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Dendrons,Imidazoles,Pyrroles,Spectroscopy,Zinc Get e-Alerts
Degradation effects in a-Si:H thin film transistors and their impact on circuit performance (2008)

Amorphous silicon thin film transistors degrade with electrical stress. In particular, the threshold voltage increases significantly with positive gate voltages. The characteristics and mechanisms of the degradation are reviewed. The implications for various types of circuitry including active matrix backplanes, integrated drivers and general purpose digital circuitry are examined. A circuit modeling tool that enables the prediction of complex circuit degradation is presented. Finally, the similarity of degradation in amorphous silicon to negative bias temperature instability in crystalline PMOS is discussed along with potential approaches to reducing the degradation effects.
Responses to an estrogenic growth promoter in beef steers fed varying nutritional regimens. (1999)

We investigated the influence of DM and(or) energy intake and dietary CP levels on the performance and nitrogen (N) retention of beef steers with and without growth promoter implants. In Exp. 1, four implanted (Synovex-S, 200 mg of progesterone plus 20 mg of estradiol benzoate) Angus steers and four Angus steers that were not implanted were assigned to concurrent 4 x 4 Latin squares. Initial BW averaged 296 kg. Each square consisted of moderate and moderately high DM intake treatments (4 and 6 kg/d) and low and adequate CP intake treatments (450 and 600 g/d) in a 2 x 2 factorial arrangement. Periods were 2 wk of adaptation, 5 wk of growth, and 1 wk of balance collection. Experiment 2 consisted of two replicates of 32 Hereford steers each (initial BW 324 kg). Each replicate was a 4 x 2 factorial in which steers were individually fed for 63 d. All steers had ad libitum access to a 60% corn-based concentrate diet containing either 7.9, 10.0, 12.1, or 14.6% CP (DM basis), and steers were either implanted or not implanted with Synovex-S. Experiment 3 was similar to Exp. 2 except that all steers (initial BW 315 kg) received a low-protein diet (7.6% CP) with calculated energy densities of either 1.86, 2.04, 2.22, or 2.42 Mcal ME/kg DM, and steers were limited to an equalized DM intake of 9.5 kg daily. In Exp. 1, gains for the low CP, moderate and moderately high DM intakes and the adequate CP, moderate and moderately high DM intakes were 240, 555, 208, and 730 g/d, respectively, for steers not implanted and 333, 643, 488, and 988 g/d, respectively, for implanted steers (SEM = 102 g/d). Respective values for retained N were .13, .18, .16, and .26 g/kg BW.75 and .13, .15, .22, and .29 g/kg BW.75 (SEM = .04 g/kg BW.75). Implant response was greater (CP x implant, P < .01) for both gain and retained N when adequate CP compared to low CP diets were fed. For Exp. 2, the lowest CP diet reduced ADG (.97 vs 1.27 kg/d) and efficiency of gain (100 vs 120 g gain/kg DM). Synovex-S was less effective in improving efficiency for the lowest protein diet than for the other diets (11.7 vs 20.2%). During Exp. 3, neither Synovex-S nor dietary energy influenced gain and efficiency. We concluded that adequate dietary protein is necessary to optimize the response to estrogenic growth promoters and that the low response under inadequate protein and energy intake is not improved by increasing the energy density of the diet.
Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions (2023)

Congenital heart disease remains one of the most frequently diagnosed congenital diseases of the newborn, with hypoplastic left heart syndrome (HLHS) being considered one of the most severe. This univentricular defect was uniformly fatal until the introduction, 40 years ago, of a complex surgical palliation consisting of multiple staged procedures spanning the first 4 years of the child's life. While survival has improved substantially, particularly in experienced centers, ventricular failure requiring heart transplant and a number of associated morbidities remain ongoing clinical challenges for these patients. Cell-based therapies aimed at boosting ventricular performance are under clinical evaluation as a novel intervention to decrease morbidity associated with surgical palliation. In this review, we will examine the current burden of HLHS and current modalities for treatment, discuss various cells therapies as an intervention while delineating challenges and future directions for this therapy for HLHS and other congenital heart diseases.
2022-RA-1290-ESGO Maintenance olaparib rechallenge in patients with ovarian cancer previously treated with a PARP inhibitor: detailed safety results from the Phase IIIb OReO/ENGOT-ov38 trial (2022)

<h3>Introduction/Background</h3> OReO/ENGOT-ov38 (NCT03106987) demonstrated a statistically significant progression-free survival benefit with maintenance olaparib rechallenge versus placebo in patients with platinum-sensitive relapsed ovarian cancer (PSROC), irrespective of <i>BRCA1/BRCA2</i> (BRCA) mutation status. Safety data were consistent with olaparib during first use; overall, olaparib discontinuation due to adverse events (AEs) was low (Pujade-Lauraine <i>et al.</i> ESMO 2021). We further characterised the tolerability of maintenance olaparib rechallenge in OReO/ENGOT-ov38, including time to onset and duration of selected AEs deemed relevant to olaparib. <h3>Methodology</h3> Patients with PSROC in response to their most recent platinum-based chemotherapy, who had received one prior maintenance PARP inhibitor, were enrolled into BRCA<i>-</i>mutated or non-BRCA-mutated cohorts. In each cohort, patients were randomised 2:1 to maintenance olaparib (300 mg) or placebo bid until disease progression. Safety and tolerability were assessed in patients receiving ≥1 dose. AEs were monitored during treatment and for 30 days after discontinuation. <h3>Results</h3> All 220 enrolled patients were included in the safety analyses (BRCA-mutated, n=112 [olaparib, n=74; placebo, n=38]; non-BRCA-mutated, n=108 [olaparib, n=72; placebo, n=36]). At data cutoff, 8 (7%) and 27 (25%) patients in the BRCA-mutated and non-BRCA-mutated cohorts, respectively, were still receiving treatment. In the BRCA-mutated cohort (olaparib arm), median time to first occurrence of nausea, vomiting, fatigue/asthenia, and anaemia was ≤32 days (table 1). Median durations of first events of nausea, vomiting, neutropenia, and thrombocytopenia were ≤38 days (table 1 for placebo comparison). In the non-BRCA-mutated cohort (olaparib arm), median time to first occurrence of all AEs was ≤29 days, excluding anaemia (table 2). Duration of first events of nausea, vomiting, neutropenia, and thrombocytopenia was ≤36 days (table 2 for placebo comparison). No cases of MDS/AML were reported (olaparib arm). <h3>Conclusion</h3> In patients with PSROC who received maintenance olaparib rechallenge, AEs usually occurred early and were generally manageable, consistent with the known safety profile of olaparib.
PCI-PipeRench and the SWORDAPI: a system for stream-based reconfigurable computing (2003)

Reconfigurable hardware accelerators have been shown to be flexible and efficient in stream-based applications. In this paper, we discuss the design of PCI-PipeRench and the SWORDAPI. PCI-PipeRench is a coprocessor utilizing the PipeRench architecture which includes on-chip control and data buffering to interface with a host processor over a PCI bus. SWORDAPI calls resemble standard C file control functions, and allow developers to create applications Independent of underlying reconfigurable hardware details. In addition, the SWORDAPI provides a cosimulation environment so that verification can be performed using unmodified application source with a hardware simulator. Efficient utilization of the bus is of critical importance in the design of such a system; various methods used to address this issue are presented.
Alternatives in Enamel Conditioning: A Comparison of Conventional and Innovative Methods (1996)

When composite restorative materials are used, conditioning of the enamel surface is necessary to achieve adequate retention of the composite material. Aside from conventional acid etching, laser treatment and pretreatment with kinetic cavity preparation technique are available. In our study, we compared the different methods using scanning electron microscopy and measurements of tensile strength. The results obtained using both laser treatments of Nd:YAG and Er:YAG lasers and kinetic cavity preparation were comparable to those obtained with the acid etching technique.
LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma (2023)

Abstract Immunotherapy has emerged as a major breakthrough that has the ability to improve survival outcomes for multiple solid tumor types, however effective response requires the combination of blocking inhibitory signals on the tumor surface and antigen presentation to the tumor surface for proper immune recognition. Several commercially available and robust methods exist for identification of tumors displaying immune-inhibitory surface receptors, including PD-L1 and CTLA-4, however it is currently difficult to predict effectiveness of antigen presentation on the cell surface. To address this, we utilized clinical and next-generation sequencing data generated by The Cancer Genome Atlas (TCGA) to identify gene signatures that are correlated to tumor mutational burden (TMB) within cancers of epithelial origins as a surrogate for neoantigen signatures. We identified LINC00261 as a top gene correlated to mutational burden (TMB), whose expression activates DNA damage response pathways in vitro along with resistance to cisplatin. LINC00261 expression was also significantly correlated to MHC Class II genes involved in endogenous neoantigen presentation expression within the TCGA-LUAD cohort. This relationship was confirmed in vitro through ectopic reintroduction of LINC00261 for key MHC Class II presentation genes. Interferon gamma-induced MHC gene activation in vitro was also able to induce endogenous expression of LINC00261 . Our results suggest there is a mechanistic relationship between LINC00261 expression and functional MHC Class II neoantigen presentation in LUAD. The silencing of LINC00261 in LUAD results in compromised DNA repair, accumulation of mutations, and reduced antitumor immune response.
Strain Rate Sensitivity of Flow Stress Measured by Micropillar Compression Test for Single Crystals of 18Cr Ferritic Stainless Steel (2019)

We have fabricated cylindrical single-crystal micropillars with different diameter (d) ranges of 2–3 µm and 5–6 µm on a specific grain in the 18Cr ferritic stainless steel with a ferrite single-phase microstructure. The initial strain rate at the onset of plastic deformation was controlled by variable loading rate in the used nanoindenter. The strain rate sensitivity of the stress required for the slip initiation were examined using the fabricated micropillars. The present compression tests addressed the shear stress on an activated single slip system of micron-scale single-crystals. Smaller-sized micropillars (d = 2–3 µm) often exhibit intermittent strain bursts. The stress for slip initiation (after an elastic loading) changes depending on the initial strain rate, resulting in a high strain rate sensitivity (m) of 0.12. Larger-sized micropillars (d = 5–6 µm) show a continuous yielding. A slight change in their yield stress depending on the initial strain rate provides a relatively low m of 0.04. It is similar to one of the millimeter-sized specimens measured by conventional tensile tests. These results provide new insights to optimize the specimen size for the micropillar compression test applied for the 18Cr ferritic stainless steels.
General Voxelization Algorithm with Scalable GPU Implementation (2007)

Abstract This paper presents an efficient algorithm for the voxelization of solid objects represented by boundary surfaces of arbitrary topology. The algorithm is based on the use of depth buffers and is suitable for polygonal meshes and parametric surfaces. The presented method unifies and extends our previous approaches under a single general algorithm; three practical variants are then given that implement it on different generations of graphics hardware in order to achieve high performance. The implementations for older hardware impose certain limitations on the depth complexity of the object.
Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial (2011)

ClinicalTrials.gov: NCT00841139 ISRCTN: ISRCTN72887836.
Control-oriented approaches to dynamic decision making (2008)

The oxylipin pathway mediates wound- and herbivore-induced defense reactions in Nicotiana attenuata as evidenced by a transient jasmonic acid (JA)-burst that precedes these defense responses. The fate of this induced JA-burst remains unknown. Two derivatives of JA, its methylester, methyl jasmonate (MeJA) and cis-jasmone (cisJ), are thought to be a means of disposing of JA through volatilization at the plant surface. In N. attenuata, the headspace quantities of these compounds did not change over 3 days, although levels of MeJA and cisJ increased 100- and 70-fold, respectively, in surface extracts of attacked leaves after feeding of Manduca sexta larvae or application of larval regurgitant to mechanical wounds. Inhibition of the wound-induced increase in JA with indole-3-acetic acid (IAA) revealed an association between the JA accumulation and subsequent increases in MeJA and cisJ. Induced systemic increases of MeJA were not of local origin and therefore do not contribute to the inactivation of the JA-burst in the wounded leaf. The total amount of MeJA and cisJ produced could only account for 9% of the JA-burst elicited by herbivore attack and therefore their production do not represent major disposal pathways of JA in N. attenuata.
Nth-order multifrequency coherence functions: A functional path integral approach. II (1980)

Nth-order multifrequency coherence functions arising in beam propagation through focusing media with random-axis misalignments and focusing media with additive statistical fluctuations are computed. The analysis is carried out by means of a simple formula which yields exact algorithmic solutions to a class of canonical path integrals.
ChemInform Abstract: Synthesis of Composite Films. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High resolution antifungal HPLC profiling for the early identification of compounds in plants from French Polynesia (2012)

In order to rapidly localize antifungal compounds in crude plant extracts, micro-dilution assays with the opportunistic yeast Candida albicans were used in combination with semi preparative HPLC micro-fractionation [1]. Using this approach, HPLC antifungal profiles of selected active crude methanolic extracts of plants from French Polynesia were efficiently recorded.