gebhart/patrepeval huggingface dataset:
Combinatorial Antibodies Against Human Malignant Melanoma (1997)

The general responsiveness of human melanoma to immunotherapy has been well established, but active immunotherapy of melanoma has been hampered by insufficient information on the immunogenicity of melanoma antigens in patients. We have attempted to identify melanoma-associated antigens recognized by patients' B cells using an antibody phage display approach. Antibody display on filamentous phages allows direct screening of cDNA libraries for expression of cell-surface-reactive antibodies, without the need for antibody production and purification using bacteria or eukaryotic cell systems. This approach was used to identify melanoma-associated cell-surface antigens recognized by patients' B cells. Antibodies produced by the B cells of a melanoma patient (in remission for > 7 years following periodic vaccination with allogeneic melanoma cell vaccine) were displayed as Fabs on the surfaces of filamentous phages. A library of 10(8) phages was absorbed to normal melanocytes, followed by phage binding to and elution from melanoma cells (human lymphocyte antigen nonmatched and vaccine melanoma cells). Phages were further selected for reactivities with tunicamycin-treated melanoma cells. These procedures resulted in a > 10(6)-fold enrichment of tumor-specific phages from the original phage library. One phage-Fab bound to melanoma cells, other tumor cells, and a few normal cells in cultured cell lines and in tissue sections.
Longitudinal antibody responses to peanut following probiotic and peanut oral immunotherapy in children with peanut allergy (2022)

PPOIT was associated with broad reduction in peanut specific humoral responses which may mediate the clinical effects of SU that persists to 4-years post-treatment.
High-speed III-V asymmetric Fabry-Perot modulators (2002)

High-speed asymmetric Fabry-Perot modulators (AFPMs) could make extremely high-aggregate-bandwidth photonic switching systems a reality. Here I review our work on the design, fabrication, and mm-wave electrical and optical characterization of AFPMs with >35-GHz frequency response.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bridging the Aesthetic Gap (2017)

To provide good results, image search engines need to rank not just the most relevant images, but also the highest quality images. To surface beautiful pictures, existing computational aesthetic models are trained with datasets from photo contest websites, dominated by professional photos. Such models fail completely in real web scenarios, where images are extremely diverse in terms of quality and type (e.g. drawings, clip-art, etc). This work aims at bridging and understanding this "aesthetic gap". We collect a dataset of around 100K web images with `quality' and `type' (photo vs non-photo) annotations. We design a set of visual features to describe image pictorial characteristics, and deeply analyse the peculiar beauty of web images as opposed to appealing professional images. Finally, we build a set of computational aesthetic frameworks based on deep learning and hand-crafted features that take into account the diverse quality of web images, and show that they significantly outperform traditional computational aesthetics methods on our dataset.
Efficient Handoff Time Decision Algorithm using Differential RSSI (2006)

본 논문은 차등 RSSI(DRSSI: Differential Received Signal Strength Indicator)를 이용하여 자원을 효율적으로 사용할 수 있는 핸드오프 처리 방안에 대해 제안한다. DRSSI는 이동국의 이동 방향을 예측하는데 사용할 수 있다. 즉, 이동국의 움직임이 바뀌는 경우 DRSSI의 극성(+, -)이 바뀌는 특성을 이용하여 이동국이 셀 사이의 중첩 지역에 머무는 동안 극성의 변화를 우선적으로 판단하여 다수의 단말기의 방향을 예측함으로써 핸드오프 및 자원을 예약할 이동국을 예측하고, 자원의 우선적인 사용권을 부여하는 방안을 제시하여 자원의 유효 상태를 극대화하는 방안을 제시한다. 또한, 수학적 모델링 분석을 통해 핸드오프 차단 확률이 기존의 방법보다 우수함을 보여준다. This paper proposes a handoff time decision mechanism to utilize resource efficiently by using Differential Received Signal Strength Indicator (DRSSI). DRSSI can be used to predict the movement direction of Mobile Station (MS). In other words, DRSSI changes its sign (+ or -) when a MS changes movement direction. This mechanism maximizes resource availability of Base Station (BS) by predicting resource reservation of MS and by giving priority of resource to MS. It is possible when a BS predicts the behavior of MSs by monitoring the DRSSI of MSs in overlapped region among cells. Additionally, we show that our proposed mechanism has better handoff blocking probability than existing mechanism with numerical modeling and analysis.
Evaluation of Hydrogen Bonding Complementarity between a Secondary Sulfonamide and an α-Amino Acid Residue (2001)

[structure: see text] We report an initial step toward the development of sulfonamide-based complements for extended peptide strands. A molecule containing one secondary sulfonamide unit and one valine residue linked by a turn-forming segment was found by IR and NMR to exhibit a doubly hydrogen-bonded folding pattern in chloroform.
Effects of nitrogen incorporation HfAlO<sub>x</sub> films on gate leakage current from XPS study of Hf bonding states (2003)

In this paper, we focus on the impact of N incorporation on the gate leakage current and the modification of the bonding configuration of HfAlO/sub x/(N) network.
Eliminating Environmental Risks in Well Construction and Workover (2002)

Abstract We are fortunate to live in a world where awareness of the detrimental effects of pollution is on the increase. Such awareness will help ensure protection of the biosphere and safeguard future generations. The oil and petrochemical industries, which have been responsible, to a large extent, for the development of the modern world and vast improvements in living standards in many places, are often targeted mercilessly by environmental activists. This is done without due regard to the criticality of oil both as a fuel and as the fundamental raw material for countless pharmaceuticals, dyes, plastics and consumer products. In general, despite press reports to the contrary, our industry has a fairly good pollution record, when compared to other major businesses. However, there is no room for complacency and it is important that we continue to be proactive in the implementation of strict environmental controls. Oil itself is usually perceived to be the biggest acute environmental threat, but, in addition, there are many well construction and workover operations that involve the use of chemical additives. Some of these materials are toxic and some may not biodegrade at acceptable rates. With an increasing awareness of the potential environmental impact of chemical additives, particularly in the marine environment, there is a continuing need to develop more efficient, less toxic alternatives. Thanks to intense efforts, many potentially harmful chemicals have already been removed from active service and replaced with new, field-proven and eco-friendly systems that have been tested in accordance with OSPARCOM guidelines, or their equivalents. Use of such materials offers benefits in terms of health and safety and, ultimately, potential cost reductions when disposal and waste handling charges are factored in. This paper reviews the development and field application of several novel materials for well completion and stimulation and suggests ways to improve or accelerate the implementation of environmental strategies.
Long‐term reliability of Er‐doped fibers in hydrogen environments (1996)

Abstract Accelerated tests of Er‐doped fibers in hydrogen environments are carried out and as the evidence of their long‐term utilization, the degradations in loss and gain are estimated. The hydrogen‐induced loss‐increase in Er‐doped fibers with 0 to 3 percent aluminum (Al) content is formulated. As the results of quantitative investigations, it is understood that during 25 years of use, there is almost no transmission loss increase in 1.55 μm wavelength region and at hydrogen partial pressure of 0.001 atm and 40°C if there is no Al content. In case of 1 wt% Al content, the loss increase is 0.04 dB/20 m while it is 0.08 dB/20 m if the Al content is 3 wt%. Further, it is possible to describe the gain degradations, under hydrogen environment, by the increase of background losses. Under the forementioned conditions, the gain degradation is estimated to be 0.07 dB if the Al content is 1 wt% and 0.15 dB if the content is 3 wt%. Therefore, it becomes clear that their characteristics are immune to hydrogen environment in real applications.
Thrombolysis of Mural Thrombus by Ultrasound (1998)

In this in vitro venous flow model a lack of catheter steerability was the major obstacle to complete thrombus fragmentation in vessel calibers larger than two times the tip diameter. The rate of embolism and the amount of remaining thrombus that could not be removed from the vessel were higher in the larger vessels.
Fractal dimension detects seizure onset in mesial temporal lobe epilepsy (2003)

The fractal dimension (FD) of a waveform is presented as a tool for detecting electrographic and predicting clinical onset of seizures (Sz) in 5 patients with mesial temporal lobe epilepsy (MTLE). Sixty-seven 1-hour intracranial EEG (IEEG) records, 25 containing Szs and 42 randomly chosen baselines /spl ges/6 hrs from Szs, were analyzed from 5 patients during presurgical evaluation. Szs were detected an average of 9.8 seconds after EEG onset and 52 seconds prior to clinical onset. There were no false positive or false negative detections. It is concluded that FD of the IEEG waveform is a promising method for real-time detection of electrographic and prediction of clinical onset of epileptic Szs early enough to warn of impending events and potentially to trigger abortive therapy.
The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications (2021)

ABSTRACT Innate immunity modulates adaptive immunity and defines the magnitude, quality, and longevity of antigen-specific T- and B- cell immune memory. Various vaccine and administration factors influence the immune response to vaccination, including the route of vaccine delivery. We studied the dynamics of innate cell responses in blood using a preclinical model of non-human primates immunized with a live attenuated vaccinia virus, Modified vaccinia virus Ankara (MVA), and mass cytometry. We previously showed that MVA induces a strong, early, and transient innate response, but also late phenotypic modifications of blood myeloid cells after two months when injected subcutaneously. Here, we show that the early innate effector cell responses and plasma inflammatory cytokine profiles differ between subcutaneous and intradermal vaccine injection. Additionally, we show that the intradermal administration fails to induce more highly activated/mature neutrophils long after immunization, in contrast to subcutaneous administration. Different batches of antibodies, staining protocols and generations of mass cytometers were used to generate the two datasets that were compared. Mass cytometry data were analyzed in parallel using the same analytical pipeline based on three successive clustering steps, including SPADE, and categorical heatmaps were compared using the Manhattan distance to measure the similarity between cell cluster phenotypes. Overall, we show that the vaccine per se is not sufficient for the late phenotypic modifications of innate myeloid cells, which are evocative of innate immune training. Its route of administration is also crucial, likely by influencing the early innate response, and systemic inflammation, and the vaccine biodistribution.
9.7 Background Multi-Rate LMS Calibration Circuit for 15MHz-BW 74dB-DR CT 2–2 MASH ΔΣ ADC in 28nm CMOS (2020)

The mm-wave radar is an indispensable component for autonomous driving. A continuous-time (CT) ΔΣ ADC is expected to be suitable for this application due to its high precision and wide bandwidth as well as inherent anti-aliasing effect. However, the stable performance of the ADC against excessive input and PVT variations is a primary issue for real products which has so far not been addressed sufficiently. Since a high OSR for a wide-band CT ΔΣ ADC requires a prohibitively high sampling rate, the higher-order noise shaping [1] needs to be applied instead. In addition, the MASH structure [2-3] is preferred due to its robustness against the instability caused by excessive input. However, since the analog transfer function of a CT MASH ΔΣ ADC is vulnerable to PVT variations, significant quantization-noise leakage occurs due to mismatch of the transfer function between analog and digital domains. Although the sturdy-MASH (SMASH) structure [4] can obviate the transfer-function matching on the first stage, it requires a zero-order second stage for sufficient matching on this stage, which needs to be compensated by a 4b quantizer and noise coupling [5]. Such design complication makes the PVT-robust operation of SMASH a critical issue.
Supplementary Figure and Table Legend from C-Propeptides of Procollagens Iα1 and II that Differentially Accumulate in Enchondromas versus Chondrosarcomas Regulate Tumor Cell Survival and Migration (2023)

Supplementary Figure and Table Legend from C-Propeptides of Procollagens Iα1 and II that Differentially Accumulate in Enchondromas versus Chondrosarcomas Regulate Tumor Cell Survival and Migration
Design of digital waveform set for multiuser CDMA communications with matched filter receivers (2004)

This paper presents a new approach for the design of a set of bandwidth-efficient quasiorthogonal digital filters which can be used as signature waveforms for multiuser CDMA communication systems. The design problem is formulated in such a way when matched filter is used at the receiver end, the overall impulse response from the transmitter to the receiver will approximated be a Nyquist pulse. It will be shown that the digital waveform set design problem can be converted to a constrained nonlinear minimax optimization problem. For bandwidth efficiency, all the digital waveforms in the set are designed to have approximately the same desired magnitude spectral shape in a prescribed passband. To minimize intersymbol and cochannel interferences, all the digital waveforms in the set are constrained to have low autocorrelation at nonzero translates of multiple symbol intervals and low cross correlation at all translates of multiple symbol intervals. Methods to solve the proposed optimization problem are discussed. A demodulation scheme with the proposed matched filter receiver is briefly outlined. Numerical results are presented to demonstrate the effectiveness of the proposed method.
Synthesis of the new tracer L-6-[11C]methyl-DOPA (2011)

We report a Pd-catalyzed β-arylation of cyclic α,β-unsaturated O-methyl oximes with aryl iodides. This reaction shows complete regioselectivity and excellent functional group tolerance. β-Arylation of 2-cyclohexen-1-one O-methyl oxime (existing as 2 : 1 E/Z mixture) with certain aryl iodides such as 4-iodoanisole affords only β-arylated (E)-O-methyl oximes.
Double-Stranded RNA Adenosine Deaminase ADAR-1-Induced Hypermutated Genomes among Inactivated Seasonal Influenza and Live Attenuated Measles Virus Vaccines (2010)

We sought to examine ADAR-1 editing of measles and influenza virus genomes derived from inactivated seasonal influenza and live attenuated measles virus vaccines grown on chicken cells as the culture substrate. Using highly sensitive 3DI-PCR (R. Suspène et al., Nucleic Acids Res. 36:e72, 2008), it was possible to show that ADAR-1 could hyperdeaminate adenosine residues in both measles virus and influenza virus A genomes. Detailed analysis of the dinucleotide editing context showed preferences for 5'ArA and 5'UrA, which is typical of editing in mammalian cells. The hyperedited mutant frequency, including genomes and antigenomes, was a log greater for influenza virus compared to measles virus, suggesting a greater sensitivity to restriction by ADAR-1.
The Practice of Labeling: Everything You Always Wanted to Know About Labeling (But Were Afraid to Ask) (2019)

Many data intensive applications that use machine learning or artificial intelligence techniques depend on humans providing the initial dataset, enabling algorithms to process the rest or for other humans to evaluate the performance of such algorithms. There are, however, practical issues with the adoption of human computation and crowdsourcing at scale in the real world. Building systems data processing pipelines that require crowd computing remains difficult. In this tutorial, we present practical considerations for designing and implementing tasks that require the use of humans and machines in combination with the goal of producing high quality labels.
gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor®and pyridinium polyhydrogen fluoride (2004)

2,2-diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving Selectfluor and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.
Fluorous Mixture Synthesis of Four Stereoisomers of the C21-C40 Fragment of Tetrafibricin (2010)

Correction to: Fluorous Mixture Synthesis of Four Stereoisomers of the C21-C40 Fragment of TetrafibricinSynlett 2010; 2010(04): 667-674DOI: 10.1055/s-0029-1219376
Address-based filtering for load/store speculation (2023)

Address-based filtering for load/store speculation includes maintaining a filtering table including table entries associated with ranges of addresses; in response to receiving an ordering check triggering transaction, querying the filtering table using a target address of the ordering check triggering transaction to determine if an instruction dependent upon the ordering check triggering transaction has previously been generated a physical address; and in response to determining that the filtering table lacks an indication that the instruction dependent upon the ordering check triggering transaction has previously been generated a physical address, bypassing a lookup operation in an ordering violation memory structure to determine whether the instruction dependent upon the ordering check triggering transaction is currently in-flight.
Shear wave dispersion behaviors of soft, vascularized tissues from the microchannel flow model (2016)

The frequency dependent behavior of tissue stiffness and the dispersion of shear waves in tissue can be measured in a number of ways, using integrated imaging systems. The microchannel flow model, which considers the effects of fluid flow in the branching vasculature and microchannels of soft tissues, makes specific predictions about the nature of dispersion. In this paper we introduce a more general form of the 4 parameter equation for stress relaxation based on the microchannel flow model, and then derive the general frequency domain equation for the complex modulus. Dispersion measurements in liver (ex vivo) and whole perfused placenta (post-delivery) correspond to the predictions from theory, guided by independent stress relaxation measurements and consideration of the vascular tree structure.
PD05-08 NITRIC OXIDE SUPPRESSES THE MACROPHAGE INDUCED RESISTANCE TOWARDS CSF-1R INHIBITION THERAPY IN CASTRATION RESISTANT PROSTATE CANCER (2019)

best of our knowledge, this is the first RNA-based study to investigate the molecular diversity of TP5 and the first one correlating CKDN2B to poorer prognosis in patients with prostate cancer.
Cost-sensitive Learning for Utility Optimization in Online Advertising\n Auctions (2016)

One of the most challenging problems in computational advertising is the\nprediction of click-through and conversion rates for bidding in online\nadvertising auctions. An unaddressed problem in previous approaches is the\nexistence of highly non-uniform misprediction costs. While for model evaluation\nthese costs have been taken into account through recently proposed\nbusiness-aware offline metrics -- such as the Utility metric which measures the\nimpact on advertiser profit -- this is not the case when training the models\nthemselves. In this paper, to bridge the gap, we formally analyze the\nrelationship between optimizing the Utility metric and the log loss, which is\nconsidered as one of the state-of-the-art approaches in conversion modeling.\nOur analysis motivates the idea of weighting the log loss with the business\nvalue of the predicted outcome. We present and analyze a new cost weighting\nscheme and show that significant gains in offline and online performance can be\nachieved.\n
A Comparison of Transient Heat-Pump Cycle Simulations with Homogeneous and Heterogeneous Flow Models (2014)

This paper compares the effects of two different refrigerant flow modeling assumptions on the transient performance of vapor-compression heat pump cycles. These simulations are developed in the next-generation modeling language Modelica, which uses an acausal, equation-oriented approach to describe physical systems. The effect of the flow assumptions and specific slip ratio correlations on both the equilibrium operating point and the transient behavior of the cycle are demonstrated through these simulations. It is shown that equivalent simulations with different slip ratio correlations each have different equilibrium mass inventories, and that some aspects of the transient system behavior exhibits minor differences between the representative simulations. The effect of the software implementation on the model performance is also discussed.
Confined IMCs for low temperature and high throughput D2W bonding (2022)

In this paper an integration flow is introduced for IMC insertion bonding, enabling stacking microbumps with 10um and below pitches. Confined CoSn3 pre-IMC bumps inside the cavities prevent lateral IMC growth and provide mechanical connection between Sn and sharp IMC grains during low temperature TCB process and improve the alignment. Electrical yield of 95% is obtained for single bumps connection of 20, 10 and 7um pitch bumps.
A single-clock-driven gate driver using p-type, low-temperature polycrystalline silicon thin-film transistors (2011)

A single-clock-driven shift register and a two-stage buffer are proposed, using p-type, low-temperature polycrystalline silicon thin-film transistors. To eliminate the clock skew problems and to reduce the burden of the interface, only one clock signal was adopted to the shift register circuit, without additional reference voltages. A two-stage, p-type buffer was proposed to drive the gate line load and shows a full-swing output without threshold voltage loss. The shift register and buffer were designed for the 3.31″ WVGA (800×480) LCD panel, and the fabricated circuits were verified via simulations and measurements.
Characterizing Pulmonary Function Test Changes for Patients With Lung Cancer Treated on a 2-Institution, 4-Dimensional Computed Tomography-Ventilation Functional Avoidance Prospective Clinical Trial (2022)

The current work is the first to quantitatively characterize PFT changes for patients with lung cancer treated on a prospective functional avoidance radiation therapy study. In comparison with patients treated with standard thoracic radiation planning, the data qualitatively show that functional avoidance resulted in less of a decline in DLCO and FEV<sub>1</sub>. The presented data can help elucidate the potential pulmonary function improvement with functional avoidance radiation therapy.
Delayed-Release Oral Mesalamine at 4.8 g/day (800 mg tablet) for the Treatment of Moderately Active Ulcerative Colitis: The ASCEND II Trial (2005)

Patients with moderately active ulcerative colitis treated with 4.8 g/day of mesalamine (800 mg tablet) are significantly more likely to achieve overall improvement at 6 wk compared to patients treated with 2.4 g/day.