gebhart/patrepeval huggingface dataset:
β-adrenergic signaling modulates the development and activity of erythroid suppressor cells (2022)

Abstract The neuroimmune response to stress has been linked to enhanced tumor proliferation, angiogenesis, and metastasis. In particular, signaling through β-adrenergic receptors has been demonstrated to promote a highly immunosuppressive tumor microenvironment by favoring the development and recruitment of suppressive immune cells, including regulatory T cells and myeloid-derived suppressive cells, that inhibit the cytotoxic CD8+ T cell response and enhance tumor progression. Interestingly, the complexity and scope of cancer immunosuppression extends beyond classical immune cells. Immunosuppressive erythroid progenitors, deemed erythroid suppressor cells (ESCs), have been shown to be prominent players in suppressing CD8+ T cell-mediated tumor responses; however, little is known about how these cells develop and are regulated. Thus, we examined if β-adrenergic signaling affects the development of ESCs and their role in tumor immunity. In this study, we show that β-adrenergic signaling promotes the accumulation of CD71+ Ter119+ erythroid progenitors consistent with the phenotypic description of ESCs in tumor-bearing mice. In characterizing the phenotype of these cells by flow cytometry and single-cell RNA sequencing, we elucidate unique features that endow these cells with immunosuppressive activity and illustrate their sensitivity to regulation by the sympathetic nervous system. We further demonstrate these erythroid precursors exhibit suppressive effects on the CD8 response. These findings elucidate a previously unappreciated axis of neuroimmune coordination in cancer and are pivotal to understanding crucial elements of tumor progression that will help shape the course of targeted immunotherapies in the future.
Changes in the Levels of Some Macromolecules and Certain Enzyme Activities in Excysting Schizopyrenus russelli (1971)

SYNOPSIS. Changes in macromolecular content and certain enzyme levels have been studied during excystment of Schizopyrenus russelli. Protein, RNA and DNA increase with the onset of excystment, the increase being more marked in the first 2 hr than later. Cellulose content is considerably decreased as the trophozoites start emerging from the cysts. There is no significant change in glycogen content. Enzyme activities of glutamic oxalacetic transaminase and ribonuclease increase while those of aldolase and isocitric dehydrogenase decrease as excystment proceeds.
Early Complications of Surgical Versus Conservative Treatment of Isolated Type II Odontoid Fractures in Octogenarians (2008)

Type II odontoid fractures in the octogenarian population are associated with substantial morbidity and mortality, irrespective of management method. Prospective studies are needed to better elucidate management strategies for this difficult clinical problem.
Integration of nanoelectromechanical (NEM) relays with silicon CMOS with functional CMOS-NEM circuit (2011)

This paper demonstrates electrical results of an integrated Si CMOS-electrostatically actuated nanoelectromechanical (NEM) relay circuit. This is an initial step towards realizing previously proposed NEM-CMOS hybrid circuits that predict various benefits compared to CMOS-only circuits. In this work, an e-beam patterned laterally actuated Pt NEM relay is fabricated at CMOS-compatible temperatures (≤ 400 °C) on top of CMOS and is driven by an on-chip CMOS inverter at V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</inf> = 6 V.
Brain tumors: MR imaging with gadolinium-DTPA. (1985)

Magnetic resonance (MR) imaging was performed on 40 patients with intracranial tumors, before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). Precontrast studies included a comprehensive protocol of spin-echo sequences. Tumors were visualized on precontrast images either directly or indirectly by anatomic distortion caused by the mass. However, differentiation of the tumor from adjacent tissues was possible in only 17 of 40 cases. Delineation of the tumor was best on precontrast, T2-weighted images. After administration of Gd-DTPA (0.1 mmol/kg), increased signal intensity from the tumor was observed in all patients. The localized increase in signal intensity in the tumor considerably improved the tumor delineation in 36 of 40 patients. Whereas most of the meningiomas, neuromas, and adenomas could be delineated prior to administration of contrast material if appropriate pulse sequences were applied, glioblastomas and intracranial metastases required Gd-DTPA administration for diagnostically sufficient tumor display.
Control of capacitor commutated converters in long cable HVDC-transmission (2002)

HVDC transmission over long distances is becoming more common, partly due to the deregulated environment in the electricity industry. The capacitor commutated converter (CCC) is a new type of HVDC converter topology which shows promise for use in long distance transmission via cables. This technology is, thus, a potential candidate for use in HVDC transmission across large bodies of water. Several HVDC-connections with cable lengths of about 600 km are currently in the planning stage in Northern Europe. This paper proposes two possible control options for such extremely long cable HVDC-connections. The suitability of these control alternatives in a CCC-inverter based HVDC-scheme terminating in a weak AC-network, is investigated using electromagnetic transient simulation.
Quantitative Reverse Transcriptase Polymerase Chain Reaction and the Oncotype DX Test for Assessment of Human Epidermal Growth Factor Receptor 2 Status: Time to Reflect Again? (2011)

It seems that controversy is ever present regarding the optimal approach to testing for human epidermal growth factor receptor 2 (HER2) status in breast cancer. There are at least two aspects to the controversy. First, is there an optimal test or approach for all patients? Second, is it reasonable to expect perfection with any single approach? These issues are highlighted by several recent reports that focus on the use of reverse transcriptase polymerase chain reaction (RT-PCR) for HER2. In a study of more than 800 patients from three hospitals, Dabbs et al suggests that RT-PCR, specifically when performed in the context of the Oncotype DX test, showed a striking level of discordance with immunohistochemistry (IHC)/fluorescent in situ hybridization (FISH) results. In their report, Dabbs et al focus on the high false-negative rate for a HER2 quantitative RT-PCR (qRT-PCR) approach in cases that are clearly HER2 positive according to FISH analyses. These data seem to contradict data from an earlier study by Baehner et al, which suggested that concordance between the qRT-PCR component of the Oncotype DX assay and FISH was greater than the 95% threshold required by the American Society of Clinical Oncology (ASCO) –College of American Pathologists (CAP) guidelines on HER2 testing for the validation of a novel approach for HER2 testing. Clinicians and patients alike need a clear understanding of the differences, if any, between the reports by Baehner et al and Dabbs et al. In addition, we needguidelines(providedbyASCO-CAPandotherexperts, forexample) regarding the appropriate use of additional tests beyond conventional IHC and FISH. Finally, the present findings should be considered carefully by those using or supplying qRT-PCR tests.
Immunbiologie der Transplantatabstoßung und deren pharmakologische Beeinflussung (2008)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Exploiting Nonlinear Behavior of MEMS Resonators for Filter Applications (2017)

We propose combining the hardening and softening nonlinearities of two resonators to realize a near flat pass band filter of almost zero roll-off. The device is composed of two near identical doubly clamped and laterally actuated microbeams made of Silicon. One of the resonators is buckled via thermal loading to produce softening resonance peak. It is then further tuned to create the desired overlap with the hardening resonance peak of the other resonator. This overlapping improves the filter’s pass band flatness and roll-off characteristics, which are highly desirable. This technique can be promising for future generation of filters with superior characteristics.
Metabolomic/lipidomic‐based analysis of plasma to diagnose hepatocellular ballooning in patients with non‐alcoholic fatty liver disease: A multicenter study (2020)

Plasma levels of PC were positively correlated, and those of lysophosphatidylcholine and LPE were negatively correlated with hepatocellular ballooning in NAFLD patients. These non-invasive metabolic/lipidomic-based plasma tests might be useful to distinguish between cases of NAFLD with and without hepatocellular ballooning.
ChemInform Abstract: Olefin/Paraffin Alkylation: Evolution of a “Green” Technology (2010)

Abstract Review: 28 refs.
The iKnife: Analysis of diathermy plumes by high-resolution mass spectrometry provides real-time identification of colorectal cancer liver metastases (2012)

Background: Minimal technologies exist that provide tissue specific molecular information to the surgeon in real-unsupervised principal components time. Rapid evaporative ionization mass spectrometry allows near real-time characterization of tissue by mass spectrometric analysis of the smoke plume released during electrosurgical dissection. Objectives: To develop and optimize a statistical strategy for the real-time recognition of cancer margin status during surgical excision of liver metastases. Methods: Fresh tissue samples from 25 patients with liver metastasis from colorectal adenocarcinoma were collected and analyzed using monopolar diathermy coupled to ion trap mass spectrometry. At the point of rapid evaporation of tissues during electrosurgical dissection, tissue specific charged particles are formed and these ionized molecular species are transferred within the diathermy plume to the mass spectrometer using Venturi air jet pump and PTFE tubing. Intense spectral profiles are produced (m/z range: 600-900) which are associated with the structural phospholipid content of tissues and vary significantly between the distinct histological tissue types. Results: The resulting dataset was analyzed by unsupervised principal components analysis for explorative analysis of similarities/differences in molecular ion composition between samples. The maximum margin criterion analysis, a supervised dimension reduction technique, was subsequently applied to extract tissue specific discriminating molecular ion patterns. The 3-nearest neighbour classification algorithm was applied on a reduced set of discriminant features and 10-fold cross validation carried out. Discrimination of healthy and malignant tissue was possible with a sensitivity of 96.8% and cross validation demonstrated the validity of the supervised methods. Conclusion: When paired with real-time data analysis, the iKnife is a viable potential method of real-time tissue identification including the intra-operative assessment of oncological resection margins.
Formic acid dehydrogenation over Pd NPs supported on amine-functionalized SBA-15 catalysts: structure–activity relationships (2017)

A series of Pd/SBA-15-amine materials (where “Amine” is primary amine, secondary amine and tertiary amine) containing Pd nanoparticles are synthesized and their catalytic properties for formic acid dehydrogenation are investigated.
An Integrated Approach To Monitoring A Field Test Of In Situ Contaminant Destruction (1999)

The development of in situ thermal remediation techniques requires parallel development&lt;br&gt;of techniques capable of monitoring the physical and chemical changes for purposes of&lt;br&gt;process control. Recent research indicates that many common contaminants can be&lt;br&gt;destroyed in situ by hydrous pyrolysis/oxidation (HPO), eliminating the need for costly&lt;br&gt;surface treatment and disposal. Steam injection, combined with supplemental air, can&lt;br&gt;create the conditions in which HP0 occurs. Field testing of this process, conducted in the&lt;br&gt;summer of 1997, indicates rapid destruction of polycyclic aromatic hydrocarbons (PAHs).&lt;br&gt;Previous work established a suite of underground geophysical imaging techniques capable&lt;br&gt;of providing sufficient knowledge of the physical changes in the subsurface during thermal&lt;br&gt;treatment at sufficient frequencies to be used to monitor and guide the heating and&lt;br&gt;extraction processes. In this field test, electrical resistance tomography (ERT) and&lt;br&gt;temperature measurements provided the primary information regarding the temporal and&lt;br&gt;spatial distribution of the heated zones.&lt;br&gt;Verifying the in situ chemical destruction posed new challenges. We developed field&lt;br&gt;methods for sampling and analyzing hot water for contaminants, oxygen, intermediates&lt;br&gt;and products of reaction. Since the addition of air or oxygen to the contaminated region is&lt;br&gt;a critical aspect of HPO, noble gas tracers were used to identify fluids from different&lt;br&gt;sources. The combination of physical monitoring with noble gas identification of the native&lt;br&gt;and injected fluids and accurate fluid sampling resulted in an excellent temporal and spatial&lt;br&gt;evaluation of the subsurface processes, from which the amount of in situ destruction&lt;br&gt;occurring in the treated region could be quantified. The experimental field results&lt;br&gt;constrain the destruction rates throughout the site, and enable site management to make&lt;br&gt;accurate estimates of total in situ destruction based on the recovered carbon. As of&lt;br&gt;October, 1998, over 400,000 kg (900,000 lb) of contaminant have been removed from the&lt;br&gt;site; about 18% of this has been destroyed in situ.
Multiagent Plan Execution and Work Practice: Modeling Plans and Practices Onboard the ISS (2021)

Numerous interdependent and uncertain constraints affect plan execution onboard a space ship. Plans are often invalid as they are being executed in the real world. Human work practices partly develop to deal with these realities. However, practices are difficult to study and represent within traditional planning tools. We discuss how modeling the work practices of the ISS Crew is used to develop a plan execution method that can deal with real world situations onboard the ISS. Brahms—a multiagent activity-based language—is used to model situated action and plan execution of human activities in practice.
Electronic structure of isothiocyanatopentacyanoferrate(III) and related complexes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure of isothiocyanatopentacyanoferrate(III) and related complexesDiane F. Gutterman and Harry B. GrayCite this: Inorg. Chem. 1972, 11, 8, 1727–1733Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/ic50114a001https://doi.org/10.1021/ic50114a001research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Conversion of multilayer graphene into continuous ultrathin sp3-bonded carbon films on metal surfaces (2013)

The conversion of multilayer graphenes into sp^3-bonded carbon films on metal surfaces (through hydrogenation or fluorination of the outer surface of the top graphene layer) is indicated through first-principles computations. The main driving force for this conversion is the hybridization between carbon sp^3 orbitals and metal surface dz^2 orbitals. The induced electronic gap states in the carbon layers are confined in a region within 0.5 nm of the metal surface. Whether the conversion occurs depend on the fraction of hydrogenated (fluorinated) C atoms and on the number of stacked graphene layers. In the analysis of the Eliashberg spectral functions for the sp^3 carbon films on diamagnetic metals, the strong covalent metal-sp^3 carbon bonds induce soft phonon modes that predominantly contribute to large electron-phonon couplings, suggesting the possibility of phonon-mediated superconductivity. Our results suggest a route to experimental realization of large-area ultrathin sp^3-bonded carbon films on metal surfaces.
A Clinician’s Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (RADAR III) (2018)

The RADAR III Group recommends next generation imaging techniques in select patients in whom disease progression is suspected based on laboratory (biomarker) values, comorbidities and symptoms. Currently <sup>18</sup>F-fluciclovine and <sup>68</sup>Ga prostate specific membrane antigen positron emission tomography/computerized tomography are the next generation imaging agents with a favorable combination of availability, specificity and sensitivity. There is ongoing research of additional next generation imaging technologies, which may offer improved diagnostic accuracy and therapeutic options. As next generation imaging techniques evolve and presumably result in improved global accessibility, clinician ability to detect micrometastases may be enhanced for decision making and patient outcomes.
Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer (2017)

Zika virus (ZIKV) is a mosquito-borne flavivirus that recently emerged in the South Pacific, Americas, and Caribbean islands, where the larger epidemics were documented. ZIKV infection in humans is responsible for neurological disorders and microcephaly. Flavivirus NS1 is a non-structural glycoprotein that is expressed on the cell surface and secreted as a hexameric lipoprotein particle. Intracellular NS1 exists as a dimer that is required for viral replication, whereas the secreted NS1 hexamer interacts with host factors, leading to pathophysiological conditions. In an effort to dispose of specific anti-ZIKV NS1 immune serum, Vero cells were transduced with a lentiviral vector containing the NS1 gene from an epidemic strain of ZIKV. We showed that stably transduced Vero/ZIKV NS1 cell clone was efficient in the secretion of recombinant NS1 oligomer. Immunization of adult rat with purified extracellular NS1 developed anti-ZIKV antibodies that specifically react with the NS1 dimer produced in human cells infected with African and Asian strains of ZIKV. The rat antibody against ZIKV NS1 dimer is a reliable biological tool that enables the immunological detection of secreted NS1 from host-cells infected with ZIKV.
Robust 1-Bit Compressive Sensing via Binary Stable Embeddings of Sparse Vectors (2013)

The compressive sensing (CS) framework aims to ease the burden on analog-to-digital converters (ADCs) by reducing the sampling rate required to acquire and stably recover sparse signals. Practical ADCs not only sample but also quantize each measurement to a finite number of bits; moreover, there is an inverse relationship between the achievable sampling rate and the bit depth. In this paper, we investigate an alternative CS approach that shifts the emphasis from the sampling rate to the number of bits per measurement. In particular, we explore the extreme case of 1-bit CS measurements, which capture just their sign. Our results come in two flavors. First, we consider ideal reconstruction from noiseless 1-bit measurements and provide a lower bound on the best achievable reconstruction error. We also demonstrate that i.i.d. random Gaussian matrices provide measurement mappings that, with overwhelming probability, achieve nearly optimal error decay. Next, we consider reconstruction robustness to measurement errors and noise and introduce the binary <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\epsilon $</tex></formula> -stable embedding property, which characterizes the robustness of the measurement process to sign changes. We show that the same class of matrices that provide almost optimal noiseless performance also enable such a robust mapping. On the practical side, we introduce the binary iterative hard thresholding algorithm for signal reconstruction from 1-bit measurements that offers state-of-the-art performance.
Third order nonlinearities in Ge-As-Se-based glasses for telecommunications applications (2004)

We have studied the third order optical nonlinearities of Ge-As-Se-based glasses. The glasses have high melting and glass transition temperatures that offer the potential for integration with traditional compound oxide glasses into highly nonlinear, high-index-contrast fibers. We used z-scan and femtosecond pump-probe techniques to measure the nonlinear refractive index and two-photon absorption coefficient of the glasses at telecommunication wavelengths. Nonlinearities as high as ∼900× that of silica were measured at 1540nm in Ge35As15Se50 with a glass transition temperature of 380°C.
Nuclear Magnetic Resonance and Methylation Analysis-Derived Structural Features of Water-Extractable Arabinoxylans from Barley (Hordeum vulgare L.) Malts (1997)

Water-extractable arabinoxylans (WEAX) were precipitated with ethanol (65%, v/v) in water extracts of six barley malts. The precipitates consisted of 82−89% arabinoxylan (carbohydrate basis) with arabinose to xylose ratios from 0.60 to 0.76. The WEAX recovered represented up to 50% of all WEAX present in barley malt (43−49.5%). Methylation analysis of these WEAX showed a low proportion of O-3 monosubstituted xylose residues (5.1−7.1%), a high proportion of disubstituted xylose residues (24.8−28.0%), and the presence of O-2-monosubstituted xylose residues (5.1−6.8%). Relative proportions of unsubstituted, monosubstituted, and disubstituted xylose resulting from the methylation analysis were confirmed by 1H-nuclear magnetic resonance (1H-NMR) spectral data. Calculations from 1H-NMR spectral data appear to overestimate the level of O-2-monosubstituted xylose residues. Size exclusion chromatography could not reveal significant differences in WEAX molecular weight profiles between the six malts. The molecular weight profiles showed a peak at about 38 kDa. Keywords: Arabinoxylan; barley malt; structure; nonstarch polysaccharides
Efficient room temperature aqueous Sb2S3 synthesis for inorganic–organic sensitized solar cells with 5.1% efficiencies (2015)

Sb2S3 sensitized solar cells are a promising alternative to devices employing organic dyes. The manufacture of Sb2S3 absorber layers is however slow and cumbersome. Here, we report the modified aqueous chemical bath synthesis of Sb2S3 absorber layers for sensitized solar cells. Our method is based on the hydrolysis of SbCl3 to complex antimony ions decelerating the reaction at ambient conditions, in contrast to the usual low temperature deposition protocol. This simplified deposition route allows the manufacture of sensitized mesoporous-TiO2 solar cells with power conversion efficiencies up to η = 5.1%. Photothermal deflection spectroscopy shows that the sub-bandgap trap-state density is lower in Sb2S3 films deposited with this method, compared to standard deposition protocols.