gebhart/patrepeval huggingface dataset:
Adaptive focusing for bone and motion artifacts corrections in High Intensity Focused Ultrasound Therapy (2008)

Despite extensive and fast progress of HIFU clinical applications, many issues still need to be addressed. Distortions caused by defocusing obstacles, such as the skull or ribs, on the ultrasonic therapeutic beam are still being investigated. Multi-element transducer technology must be used in order to achieve such transcranial or transcostal adaptive focusing. Second, the problem of motion artifacts, a key component in the treatment of abdominal lesions, has been shown to significantly influence the efficacy and treatment time. Though many methods have been proposed for the detection of organ motion, little work has been done to develop a comprehensive solution including motion tracking and feedback correction in real time. This paper is a review of the work achieved by authors in transcranial HIFU, transcostal HIFU, and motion compensated HIFU. For these three issues, the optimal solution can be reached using the same technology of multi-element transducers devices able to work both in Transmit and Receive modes.
An Integration Model for Access to Archaeological Collections Using Multimodal Interaction in Virtual Environments (2012)

This paper aims to develop ways of assisting the production process of virtual environments with multimodal interaction, for displaying objects and environments, especially those that require special handling, such as rare or fragile artifacts. The main conclusions of this work were: (i) The virtual model produced to be displayed in the virtual environment had the same result, both for individuals with training in three-dimensional modeling and for users without this training, (ii) the developed mechanism may be used by any person and especially by any cultural center, which can be considered the most relevant contribution of this project.
Efficacy and side effects of individualized versus standard panretinal photocoagulation for treatment-naive proliferative diabetic retinopathy:: results from a randomized clinical trial (2020)

Purpose : Proliferative diabetic retinopathy (PDR) is as a standard treated with panretinal photocoagulation (PRP). However, this treatment is known to cause side effects such as loss of visual fields (VF) and affection of night vision. To address this, we conducted a 6-month prospective, single-blinded randomized clinical trial (RCT) of patients with treatment-naïve PDR, where we investigated efficacy, side effects and retinal quality of life (RQOL) of patients treated with individualized navigated PRP (targeting only affected retinal quadrants) as compared to standard (all quadrants) navigated PRP.<br/><br/>Methods : We included 53 eyes of 42 patients with treatment-naïve PDR. Patients were randomized to individualized (targeting only affected retinal quadrants) or standard (targeting all retinal quadrants) PRP. Navilas ® laser was used for treatment. VF and dark adaptation (DA) were measured and a validated Danish version of Visual Function Questionnarie-25 was filled out by the patients at baseline prior to PRP and at 6 months follow up (M6). Main outcome measure were efficacy and safety of individualized and standard PRP.<br/><br/>Results : There was no difference in the number of patients with disease progression at M6 (individualized: 48.0% vs. standard: 59.3%, p=0.27). Furthermore VF (VFI (individualized: 92.5±7 vs. standard: 95.5±8, p=0.13); MD (individualized: -4.70±4.23 vs. standard: -3.47±4.22, p=0.25)), DA (individualized: 0.41666±0.051 vs. standard: 0.41340±.0.059, p=0.76), best corrected visual acuity (individualized: 85±10 vs. standard: 88±7, p=0.19), and RQOL (individualized: 90.9±2.4 vs. standard: 89.6±10.4, p=0.41) did not differ between the groups at M6.<br/><br/>Conclusions : In this RCT of patients with treatment-naïve PDR, individualized PRP targeting only affected retinal quadrants had the same efficacy and safety as standard PRP; furthermore side-effects (VF and DA) and RQOL did not differ. In future studies it would be interesting to test individualized PRP on a larger cohort with a longer follow-up period to confirm the long-term effects of a less intensive PRP.<br/><br/>This is a 2020 ARVO Annual Meeting abstract.
Improving Resistance Switching Characteristics with SiGeOx/SiGeON Double Layer for Nonvolatile Memory Applications (2011)

The switching layer with SiGeOx/SiGeON structure is investigated to improve the electrical characteristics of resistive nonvolatile memory. A bipolar resistance switching behavior owning inferior stability was observed in Pt/SiGeOx/TiN memory cells. To obtain practical memory, a convenient and compatible SiGeON (∼5 nm) is introduced at SiGeOx/anode interface to stabilize the disruption length of filaments near anode electrode. Compared with Pt/SiGeOx/TiN memory cells, the proposed Pt/SiGeOx/SiGeON/TiN cells is effective at minimizing the dispersions of memory switching parameters.
Les relations financières entre l'État et les collectivités territoriales : un sauvetage des conseils généraux orchestré au prix fort (2011)

Résumé L’examen des ressources transférées aux conseils généraux pour assurer la compensation financière de l’ensemble des transferts mis à leur charge dans le champ de l’aide et de l’action sociales au cours de la décennie passée montre une déconnexion entre les dynamiques des recettes et des dépenses. L’attribution de fonctions de solidarité nationale à des collectivités locales apparaît comme une stratégie ambiguë de sauvetage des conseils généraux. Génératrice d’effets pervers, notamment en termes d’inégalités, elle contraint les élus départementaux à prendre en charge les arbitrages impopulaires résultants de décisions nationales, et souligne l’ambiguïté du statut des conseils généraux qui en résulte, pris entre deux modèles concurrents : la collectivité locale et l’opérateur étatique.
All-optical access node using a novel self-synchronization scheme (2002)

Summary form only given. We demonstrate all-optical serial processing for a 100-Gbit/s access node using a novel self-synchronization scheme, which utilizes gain saturation in a semiconductor laser amplifier (SLA) followed by self-phase modulation (SPM) in an optical fiber. The contrast ratio for the header processor is 10:1 and for the demultiplexer is 20:1. Our design avoids the complexity of generating and propagating marker pulses because all pulses in the frame can be identical.
A single-imager stereoscopic endoscope (2011)

We have developed a 5.5mm and 10mm dual optical channel laparoscope that combines both exit channels into a single, standard, endoscopic eye cup which attaches directly to a single, conventional HD camera head. We have also developed image processing software that auto-calibrates, aligns, enhances and processes the image so that it can be displayed on a stereo/3D display to achieve a true 3D effect. The advantages to the end user for such a 3D system are that they do not have to purchase a new camera system, all of their existing scopes are still available to use, as are all integrated OR features. They will be able to add 3D capability to current HD system by purchasing only stereo scopes and a small video processing computer box and adding a 2D/3D HD capable monitor.
Data for: Active Grain Growth Control with Distributed Heating (2020)

# List of Data Sets 5 sets of data are included in total: 1. output_feedback/consensus_tracking: Figure 7 (a) (b) 2. output_feedback/consensus_only: Figure 7 (c) (d) 3. MPC/consensus_tracking: Figure 9 (a) (b) 4. MPC/consensus_only: Figure 9 (c) (d) 5. inner_outer_loop/consensus_only: Figure 10 (c) (d) # Description of Dataset Every data set contains 5 files: 1. input_current.txt: 11 columns. The first column stores time (unit: second). The other 10 columns input current to the heater array (unit: mA) 2. temp_profile.txt: 32 columns. The first column stores time (unit: second). The other 31 columns store copper surface temperature at 31 node coordinates (find node coordinates in temp_cor.txt). Temperature unit: degree Kelvin 3. profile_gs.txt: 101 columns. The first column stores time (unit: second). The other 100 columns store grain size profile at 100 coordinates (find grain size profile coordinates in gs_cor.txt). Grain size unit: micrometer. 4. zone_gs.txt: 11 columns. The first column stores time (unit: second). The other 10 columns store squared grain size in 10 zones (unit micrometer^2) 5. temp_cor.txt: coordinates of temperature profile nodes. Unit: mm 6. gs_cor.txt: coordinates of grain size profile nodes. Unit: mm
Successes and challenges of artificial intelligence in cardiology (2023)

In the past decades there has been a substantial evolution in data management and data processing techniques. New data architectures made analysis of big data feasible, healthcare is orienting towards personalized medicine with digital health initiatives, and artificial intelligence (AI) is becoming of increasing importance. Despite being a trendy research topic, only very few applications reach the stage where they are implemented in clinical practice. This review provides an overview of current methodologies and identifies clinical and organizational challenges for AI in healthcare.
Absence of viremia in primary herpetic gingivostomatitis (1983)

Using current techniques of viral isolation, whole blood, plasma and buffy coat from 17 children with herpetic gingivostomatitis were cultured. Recovery of herpes simplex virus was inhibited by anticoagulation of blood with heparin and unaffected by anticoagulation with citrate. Herpes virus was not detected in any blood fraction during primary herpes gingivostomatitis.
Modeling and Pre-Treatment of Photon-Starved CT Data for Iterative Reconstruction (2016)

An increasing number of X-ray CT procedures are being conducted with drastically reduced dosage, due at least in part to advances in statistical reconstruction methods that can deal more effectively with noise than can traditional techniques. As data become photon-limited, more detailed models are necessary to deal with count rates that drop to the levels of system electronic noise. We present two options for sinogram pre-treatment that can improve the performance of photon-starved measurements, with the intent of following with model-based image reconstruction. Both the local linear minimum mean-squared error (LLMMSE) filter and pointwise Bayesian restoration (PBR) show promise in extracting useful, quantitative information from very low-count data by reducing local bias while maintaining the lower noise variance of statistical methods. Results from clinical data demonstrate the potential of both techniques.
Cognitive and Behavioral Correlates of Achievement in a Complex Multi-Player Video Game (2019)

Over the past 30 years, a large body of research has accrued demonstrating that video games are capable of placing substantial demands on the human cognitive, emotional, physical, and social processing systems. Within the cognitive realm, playing games belonging to one particular genre, known as the action video game genre, has been consistently linked with demands on a host of cognitive abilities including perception, top-down attention, multitasking, and spatial cognition. More recently, a number of new game genres have emerged that, while different in many ways from “traditional” action games, nonetheless seem likely to load upon similar cognitive processes. One such example is the multiplayer online battle arena genre (MOBA), which involves a mix of action and real-time strategy characteristics. Here, a sample of over 500 players of the MOBA game League of Legends completed a large battery of cognitive tasks. Positive associations were observed between League of Legends performance (quantified by participants’ in-game match-making rating) and a number of cognitive abilities consistent with those observed in the existing action video game literature, including speed of processing and attentional abilities. Together, our results document a rich pattern of cognitive abilities associated with high levels of League of Legends performance and suggest similarities between MOBAs and action video games in terms of their cognitive demands.
Model based pattern matching (2008)

An important need in the Optical Proximity Correction (OPC) process is to be able to identify problem correction areas. However, many times when a problem correction area is identified, multiple instances of the same problem occur throughout the correction. This can lead to potentially hundreds or thousands of repeated structures that must be filtered by the development engineer. In some instances, hundreds of thousands of problem areas may be identified, but in reality, all the areas are the same lithographic pattern. One way of identifying repeated patterns in an analysis data base is to use Boolean geometric logic to isolate matching patterns. The problem with this approach is determining what area is the area of process influence. This invariably leads to a conservative analysis of similar patterns, which leads to many repeated failures that are actually the same failure. This study will discuss a solution to this problem using process models and process model approximations to determine if patterns are the same from the point of view of the process. This will be accomplished using the output model intensity, the output model slope, and the pattern response to focus variation. When these three values are the same, it is hypothesized the layout patterns are the same from a process point of view. In addition, the study will discuss methodologies to speed up the model analysis and adjust accuracy and sensitivity.
Dynamic Kinetic Resolution of α,β‐Unsaturated Lactones through Asymmetric Copper‐Catalyzed Conjugate Reduction: Application to the Total Synthesis of Eupomatilone‐3 (2005)

Only six steps were needed for the total synthesis of eupomatilone-3 in 48 % overall yield thanks to the development of a dynamic kinetic resolution that allowed the reductive conversion of a racemic α,β-unsaturated butenolide in high yield and high enantiomeric and diastereomeric excess. This copper-catalyzed dynamic kinetic resolution was then applied to several γ-aryl-containing α,β-unsaturated butenolides.
Efficacy and safety of cilta-cel in patients with progressive multiple myeloma after exposure to other BCMA-targeting agents (2022)

B-cell maturation antigen (BCMA)-targeting therapies, including bispecific antibodies (BsAbs) and antibody-drug conjugates (ADCs), are promising treatments for multiple myeloma (MM), but disease may progress after their use. CARTITUDE-2 is a phase 2, multicohort study evaluating the safety and efficacy of cilta-cel, an anti-BCMA chimeric antigen receptor T therapy, in various myeloma patient populations. Patients in cohort C progressed despite treatment with a proteasome inhibitor, immunomodulatory drug, anti-CD38 antibody, and noncellular anti-BCMA immunotherapy. A single cilta-cel infusion was given after lymphodepletion. The primary end point was minimal residual disease (MRD) negativity at 10-5. Overall, 20 patients were treated (13 ADC exposed; 7 BsAb exposed; 1 in the ADC group also had prior BsAb exposure). Sixteen (80%) were refractory to prior anti-BCMA therapy. At a median follow-up of 11.3 months (range, 0.6-16.0), 7 of 20 (35%) patients were MRD negative (7 of 10 [70.0%] in the MRD-evaluable subset). Overall response rate (95% confidence interval [CI]) was 60.0% (36.1-80.9). Median duration of response and progression-free survival (95% CI) were 11.5 (7.9-not estimable) and 9.1 (1.5-not estimable) months, respectively. The most common adverse events were hematologic. Cytokine release syndrome occurred in 12 (60%) patients (all grade 1-2); 4 had immune effector cell-associated neurotoxicity syndrome (2 had grade 3-4); none had parkinsonism. Seven (35%) patients died (3 of progressive disease, 4 of adverse events [1 treatment related, 3 unrelated]). Cilta-cel induced favorable responses in patients with relapsed/refractory MM and prior exposure to anti-BCMA treatment who had exhausted other therapies. This trial was registered at www.clinicaltrials.gov as NCT04133636.
Analytic modeling of multitier Internet applications (2007)

Since many Internet applications employ a multitier architecture, in this article, we focus on the problem of analytically modeling the behavior of such applications. We present a model based on a network of queues where the queues represent different tiers of the application. Our model is sufficiently general to capture (i) the behavior of tiers with significantly different performance characteristics and (ii) application idiosyncrasies such as session-based workloads, tier replication, load imbalances across replicas, and caching at intermediate tiers. We validate our model using real multitier applications running on a Linux server cluster. Our experiments indicate that our model faithfully captures the performance of these applications for a number of workloads and configurations. Furthermore, our model successfully handles a comprehensive range of resource utilization---from 0 to near saturation for the CPU---for two separate tiers. For a variety of scenarios, including those with caching at one of the application tiers, the average response times predicted by our model were within the 95% confidence intervals of the observed average response times. Our experiments also demonstrate the utility of the model for dynamic capacity provisioning, performance prediction, bottleneck identification, and session policing. In one scenario, where the request arrival rate increased from less than 1500 to nearly 4200 requests/minute, a dynamic provisioning technique employing our model was able to maintain response time targets by increasing the capacity of two of the tiers by factors of 2 and 3.5, respectively.
Zr-based metallic glass as a novel MEMS bonding material (2011)

In this study, for the first time we successfully bonded Si substrates with sputtered Zr-Al-Cu-Ni metallic glassy material. The surface pre-treatment with formic acid vapor plays a remarkable function for oxides removal before bonding. Metallic glasses have fundamentally glassy structure and exhibit a Newtonian viscous flow in the supercooled liquid region. The polymer-like plastic fluidity performs superior wettability which improves interfacial integrity. This paper introduces a unique functional material and reveals its high potential for MEMS bonding application.
ChemInform Abstract: Sc(OTf)3 Promoted Multicomponent Synthesis of Fluorescent Imidazo[1,2‐c]pyrazolo[3,4‐d]pyrimidine. (2013)

Abstract Two simple protocols using Sc(OTf) 3 as the catalyst are presented for the synthesis of the title‐compounds via three component condensation of pyrazolopyrimidines, aldehydes, and isocyanides.
Non-doped Na2CO3 Ceramics as a New Radio-photoluminescence (RPL) Material (2017)

In this letter, we report a new radio-photoluminescence (RPL) material. RPL is a phenomenon that new luminescent centers are generated by ionizing radiations. Sintered Na2CO3 ceramics in a vacuum s...
Smouldering Mastocytosis: A Novel Subtype of Systemic Mastocytosis with Slow Progression (2002)

Systemic mastocytosis (SM) is a clonal disease that shows an either indolent or an aggressive clinical course. Utilizing established criteria, indolent SM can readily be discriminated from the rare aggressive subvariants of SM in most cases. In a small group of patients, however, clinical and laboratory parameters are indicative of slow progression without signs of aggressive disease or an associated hemopoietic neoplasm. These SM patients exhibit a high burden of mast cells, hypercellular marrow and organomegaly. Because of the 'intermediate' course and uncertain prognosis, these cases have been referred to as smouldering SM. In the present article, we discuss clinical and laboratory findings in smouldering SM and review the current literature. In addition, the pathophysiology of this novel subtype of SM is discussed.
Mid-Regional Pro-Adrenomedullin Is Associated With Pulse Pressure, Left Ventricular Mass, and Albuminuria in African Americans With Hypertension (2009)

In African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.
Phase-locked CEST: Introducing dynamic B0-correction to gagCEST (2018)

Even a small frequency drift of less than 1Hz/min of the MRI scanner can have a strong impact on gagCEST measurements. We propose a dynamic B0-correction that tracks the frequency shift using the phase images provided by the GRE readout. We show that this correction eliminates the influence of the frequency drift on gagCEST without the need of additional measurement time allowing higher accuracy, reproducibility, and comparability of gagCEST studies.
Genetic and Biochemical Characterization of a Novel Monoterpene ɛ-Lactone Hydrolase from Rhodococcus erythropolis DCL14 (2001)

A monoterpene epsilon-lactone hydrolase (MLH) from Rhodococcus erythropolis DCL14, catalyzing the ring opening of lactones which are formed during degradation of several monocyclic monoterpenes, including carvone and menthol, was purified to apparent homogeneity. It is a monomeric enzyme of 31 kDa that is active with (4R)-4-isopropenyl-7-methyl-2-oxo-oxepanone and (6R)-6-isopropenyl-3-methyl-2-oxo-oxepanone, lactones derived from (4R)-dihydrocarvone, and 7-isopropyl-4-methyl-2-oxo-oxepanone, the lactone derived from menthone. Both enantiomers of 4-, 5-, 6-, and 7-methyl-2-oxo-oxepanone were converted at equal rates, suggesting that the enzyme is not stereoselective. Maximal enzyme activity was measured at pH 9.5 and 30 degrees C. Determination of the N-terminal amino acid sequence of purified MLH enabled cloning of the corresponding gene by a combination of PCR and colony screening. The gene, designated mlhB (monoterpene lactone hydrolysis), showed up to 43% similarity to members of the GDXG family of lipolytic enzymes. Sequencing of the adjacent regions revealed two other open reading frames, one encoding a protein with similarity to the short-chain dehydrogenase reductase family and the second encoding a protein with similarity to acyl coenzyme A dehydrogenases. Both enzymes are possibly also involved in the monoterpene degradation pathways of this microorganism.
Large Magnetostriction in Oriented Particle Terfenol-D Composites (2001)

Abstract Magnetostrictive composite materials have been extensively investigated to overcome limitations of the monolithic form such as frequency response and durability, but have previously shown decreased saturation strain as compared to the monolithic materials. This paper attempts to overcome this limitation by manufacturing composites with particle orientation along a specific crystal axis. Shape anisotropy was used during manufacture to orient needle shaped particles along their longest dimension, near the [112] direction. Measurements reveal that the saturation magnetostriction has been increased from ∼1200 ppm for a non-oriented composite (at 12 MPa compressive stress) to over 1550 ppm for a [112] oriented composite (under 12 MPa compressive stress). This is the largest magnetostriction reported as yet for a composite material. A key conclusion of this study is that the dominant influence on the orientation of Terfenol-D particles aligned during manufacture is the shape anisotropy and not the magnetocrystalline anisotropy. Furthermore, the necessary applied fields to reach similar magnetostriction have been reduced in the oriented particle composite as compared to the non-oriented particle composite. In addition, a rule of mixtures model has been used to determine that the composite exhibits nearly the maximum rule of mixtures prediction for magnetostriction.