gebhart/patrepeval huggingface dataset:
(Invited) On Teaching Electrochemical Impedance Spectroscopy (2019)

Impedance spectroscopy is a popular electrochemical measurement technique, but successful implementation requires specialized training that is not easily available. At the 2013 ISE annual meeting in Querétaro, we described our philosophy for teaching electrochemical impedance spectroscopy, embodied in our textbook on the subject, published in 2008 [1]. At the 2017 ISE annual meeting in Providence, we updated our discussion, with emphasis on the second edition of our book [2]. The object of this presentation is to describe our current approach to the subject, reflected in our textbooks on the subject and in our new project, to which we have assigned the working title of The EIS Companion: A Compendium of Solved Problems and Resources . This communication will describe an approach towards teaching impedance spectroscopy in which students are encouraged to modify experimental parameters in accordance with the experimental system, to use a variety of graphical representations to develop preliminary estimates for physical properties, to develop models from proposed chemical, electrochemical, and physical mechanisms, and to perform regression analyses which account for the error structure of the measurement. As impedance spectroscopy is not a “stand-alone” technique, students are encouraged to seek independent observations that can be used to support or disprove the models developed. This approach will be illustrated by a step-by-step analysis of a sample data set, including preliminary graphical inspection of the data, evaluation of consistency with the Kramers-Kronig relations, development of an interpretation or process model, regression of the model to the Kramers-Kronig-consistent portion of the spectrum, and evaluation of the physical meaning of the parameters extracted. M.E. Orazem, B. Tribollet, Electrochemical Impedance Spectroscopy, John Wiley &amp; Sons, Hoboken, New Jersey, 2008. M.E. Orazem, B. Tribollet, Electrochemical Impedance Spectroscopy, 2 nd Edition, John Wiley &amp; Sons, Hoboken, New Jersey, 2017.
Supplementary Tables S1 & S2 and Figures S1a & S1b from Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition (2023)

Supplementary Tables S1 &amp; S2 and Figures S1a &amp; S1b from Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Difference in the optimum conditions for size reduction and mechanical activation by wet vibro-milling (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDifference in the optimum conditions for size reduction and mechanical activation by wet vibro-millingHideyuki Ootani and Mamoru SennaCite this: Ind. Eng. Chem. Res. 1987, 26, 6, 1214–1217Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ie00066a025https://doi.org/10.1021/ie00066a025research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Towards a Switchable AR/VR Near-eye Display with Accommodation-Vergence and Eyeglass Prescription Support (2019)

In this paper, we present our novel design for switchable AR/VR near-eye displays which can help solve the vergence-accommodation-conflict issue. The principal idea is to time-multiplex virtual imagery and real-world imagery and use a tunable lens to adjust focus for the virtual display and the see-through scene separately. With this novel design, prescription eyeglasses for near- and far-sighted users become unnecessary. This is achieved by integrating the wearer's corrective optical prescription into the tunable lens for both virtual display and see-through environment. We built a prototype based on the design, comprised of micro-display, optical systems, a tunable lens, and active shutters. The experimental results confirm that the proposed near-eye display design can switch between AR and VR and can provide correct accommodation for both.
Role of Bath Composition in Electroless Cu Seeding on Co Liner for through-Si Vias (2014)

To enable Cu fill of through-Si vias (TSV) with a high aspect ratio (diameter 3 μm, depth 50 μm), the electroless deposition of a Cu seed on Co liner material was investigated. The reducing agent glyoxylic acid showed anodic oxidation on Co, which did not appear for the case of formaldehyde. From electrochemical analysis, an optimized bath composition caused limited Co corrosion during the electroless Cu nucleation phase. The concentration ratio of the complexing agent (ethylenediaminetetraacetic acid) and copper was found to strongly impact the liner corrosion; in case free complexing agent is present in the bath, the Co corrosion was assisted by complexation and replacement reactions. A continuous seed layer could be deposited in the entire TSV, which enabled the filling by electrochemical deposition (ECD). The substantially thinner total copper overburden generated for this combination of a wet-chemical seed deposition and an ECD fill process contributes to a cost reduction of its chemical mechanical polishing (CMP).
Downregulation of Sp1 is involved in β-lapachone-induced cell cycle arrest and apoptosis in oral squamous cell carcinoma (2015)

β-lapachone (β-lap) is a naturally occurring quinone obtained from the bark of lapacho tree (Tabebuia avellanedae) with anti-proliferative properties against various cancers. The present study investigated the cell proliferation and apoptosis effect of β-lap on two oral squamous cell carcinoma lines (OSCCs). We carried out a series of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl-2H-tetrazolium (MTS) assays, 4',6-diamidino-2-phenylindole (DAPI) staining, cell cycle analysis, and western blot analysis to characterize β-lap and its underlying signaling pathway. We demonstrated that β-lap-treated cells significantly reduced cell proliferation but increased DNA condensation and increased sub-G1 population in OSCCs. Particularly, β-lap suppresses activation of transcription factor specificity protein 1 (Sp1) followed by apoptosis in a concentration-dependent manner in OSCCs. Furthermore, β-lap modulated protein expression levels of cell cycle regulatory proteins and apoptosis-related proteins that are known as Sp1 target genes, resulting in apoptosis. Our results collectively indicated that β-lap was able to modulate Sp1 transactivation and induce apoptosis through the regulation of cell cycle and apoptosis-related proteins. Therefore, β-lap may be used in cancer prevention and therapies to improve clinical outcome as an anticancer drug candidate.
Notch Signaling in Astrocytes and Neuroblasts of the Adult Subventricular Zone in Health and after Cortical Injury (2006)

The postnatal subventricular zone (SVZ) is a niche for continuous neurogenesis in the adult brain and likely plays a fundamental role in self-repair responses in neurodegenerative conditions. Maintenance of the pool of neural stem cells within this area depends on cell-cell communication such as that provided by the Notch signaling pathway. Notch1 receptor mRNA has been found distributed in different areas of the postnatal brain including the SVZ. Although the identity of Notch1-expressing cells has been established in the majority of these areas, it is still unclear what cell types within the SVZ are expressing components of this pathway. Here we demonstrate that most of expression of Notch1 in the adult SVZ occurs in polysialylated neural cell adhesion molecule (PSA-NCAM)-positive neural precursors and in glial fibrillary acidic protein-positive SVZ astrocytes. Notch1 was also found in PSA-NCAM-positive neuroblasts located within the rostral migratory stream (RMS) but much less in those that have reached the olfactory bulb. We show that two of the naturally occurring Notch1 activators, Jagged1 and Delta1, are also expressed in the SVZ and within the RMS in the adult mouse brain. Finally, using a model of cortical stab wound, we show that the astrogliogenic response of the SVZ to injury is accompanied by activation of the Notch pathway.
Experimental verification of minimum overlap size design in a FDE-based chromatic dispersion compensation circuit with a 50Gb/s PM-QPSK signal (2012)

We propose a simple design method of minimum overlap data size for overlap-FDE based CD compensation. We confirmed its validity using a real-time DSP circuit and 50.7Gbps PM-QPSK signal for up to 56,200ps/nm.
ChemInform Abstract: Studies in Silanol Synthesis: Internal Nucleophiles and Steric Hindrance. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
65‐6: Control of Oxygen Vacancy in ZnO Nanoparticles Electron Transport Layer by Intense Pulsed‐Light Post‐Treatment Under Fabrication of Ink‐Jet Printed QLEDs (2021)

Previously, we reported that the charge injection balance in spin‐coated quantum‐dot light‐emitting diodes (QLED) was achieved by controlling the current density characteristics via filling of the oxygen vacancies in Zinc oxide (ZnO) nanoparticles (NPs) through intense‐pulsed light (IPL) post‐treatment [1]. In this work, we investigated the IPL posted‐treatment induced charge balance and stability of device performance prepared by the ink‐jet printed QLED. Oxygen vacancies (Vo) in the ZnO wurtzite structure were filled with oxygen by IPL post‐treatment process in the air atmosphere, and the ink‐jet printed QLED performance remained stable during the 8 day measurement period. The current efficiency (CE) and external quantum efficiency (EQE) characteristics of ink‐jet printed QLED showed a tendency to stabilize from the 2 nd day, and the performance of the device were 34122 cd/m 2 luminance, 7.3513 cd/A CE, and 1.943 % EQE.
Mechanisms of Compensating for Anterior Cruciate Ligament Deficiency during Gait (2004)

The prevalence of multiple adaptive strategies to compensate for ACL deficiency has several important ramifications. First, an ACLd subject pool with mixed compensating strategies may deter the identification of specific coping mechanisms and account for the confounding results in the literature. Second, the importance of the hip extensors should not be overlooked when studying this population.
Mechanically reconfigurable multi-functional meta-optics studied at microwave frequencies (2021)

Metasurfaces advanced the field of optics by reducing the thickness of optical components and merging multiple functionalities into a single layer device. However, this generally comes with a reduction in performance, especially for multi-functional and broadband applications. Three-dimensional metastructures can provide the necessary degrees of freedom for advanced applications, while maintaining minimal thickness. This work explores mechanically reconfigurable devices that perform focusing, spectral demultiplexing, and polarization sorting based on mechanical configuration. As proof of concept, a rotatable device, a device based on rotating squares, and a shearing-based device are designed with adjoint-based topology optimization, 3D-printed, and measured at microwave frequencies (7.6-11.6 GHz) in an anechoic chamber.
Design and control of Ge-based metal-oxide-semiconductor interfaces for high-mobility field-effect transistors with ultrathin oxynitride gate dielectrics (2013)

High-quality Ge-based metal-oxide-semiconductor (MOS) stacks were achieved with ultrathin oxynitride (GeON) gate dielectrics. An in situ process based on plasma nitridation of the base germanium oxide (GeO2) surface and subsequent metal electrode deposition was proven to be effective for suppressing electrical deterioration induced by the reaction at the metal/insulator interface. The electrical properties of the bottom GeON/Ge interface were further improved by both low-temperature oxidation for base GeO2 formation and high-temperature in situ vacuum annealing after plasma nitridation of the base oxide. Based on the optimized in situ gate stack fabrication process, very high inversion carrier mobility (μhole: 445 cm2/Vs, μelectron: 1114 cm2/Vs) was demonstrated for p- and n-channel Ge MOSFETs with Al/GeON/Ge gate stacks at scaled equivalent oxide thickness down to 1.4 nm.
Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival (2021)

Early complement activation, assessed by plasma TCC, was associated with impaired long-term patient and graft survival.
Dispersion of functionalized silver nanoparticles in polymer matrices: Stability, characterization, and physical properties (2008)

Abstract Three types of silver/polymer nanocomposite films were prepared: (1) silver/polymethyl methacrylate, (2) silver/polystyrene, and (3) silver/polyt‐butyl methacrylate by mixing colloidal solution of functionalized Ag nanoparticles with solution of pre‐made polymers. The nanoparticles are randomly dispersed into the matrices. The desired surface functionality of Ag nanoparticle was achieved by using specific amphiphilic block copolymer (specific hydrophobic block part) as stabilizer. The stability of nanoparticles in these host hydrophobic polymer matrices was determined after annealing the nanocomposite films at high temperature. The nanoparticles remained stable and no agglomeration occurred upon annealing up to 120°C. Up to 20 wt% of block copolymer stabilized Ag nanoparticles (11% Ag) was successfully loaded in the polymer matrix. Such a dispersion of Ag nanoparticles into a hydrophobic polymer matrix significantly enhances the mechanical properties of the nanocomposite films. The storage and loss modulus increase with increasing Ag nanoparticles content. Compared with a polymer matrix, the polymer/Ag nanocomposites film (containing 0.65% of Ag) prepared by this method displayed storage modulus that are up to 130% higher. This is attributed to the high surface area of the polymer coated Ag nanoparticles in the polymer matrix and van der Waal's attraction force between surface of Ag nanoparticles (polymer brush) and host polymer matrix. Comparison of thermal properties of polymer and polymer/Ag nanocomposite films showed that the thermal stability of nanocomposites increases by about 20°C. POLYM. COMPOS., 2009. © 2008 Society of Plastics Engineers
Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma (2016)

PSMA is significantly overexpressed in ACC neovasculature when compared with normal and benign adrenal tumors. PSMA expression can be used to image ACC metastases in vivo and may be considered as a potential diagnostic and therapeutic target in ACC.
Cyclic Energy Storage in Salt Caverns: nonlinear finite-element modelling of rock salt creep at reservoir scale. (2020)

Subsurface formations provide giant capacities for renewable energy storage, when this energy is converted to green fuels such as hydrogen. A promising option for storing large-scale quantities of hydrogen is in subsurface rock salt caverns. Rock salts, however, are known to exhibit nonlinear time-dependent creep deformation. In this work, the complex creep behaviour of rock salt caverns is modelled and simulated through a 2D finite element model using unstructured grids. The developments presented allow for quantification of the state of the stress around the cavern with the aim of aiding assessments of the safety and reliability of the structure in the longer term. The study builds on the principle of minimum potential energy to consistently account for the nonlinear creep deformation using finite elements. Cyclic loading and evolution of damage within the material are incorporated to predict the failure of the material over time. Sensitivity analysis of key parameters is performed to understand the influence of creep on deformation and stress evolution around the salt cavern configurations. The simulator developed in this work is publicly available at this https URL.
Granulocyte-Macrophage Colony-stimulating Factor Signals for Increased Glucose Transport via Phosphatidylinositol 3-Kinase- and Hydrogen Peroxide-dependent Mechanisms (2003)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates cellular glucose uptake by decreasing the apparent K(m) for substrate transport through facilitative glucose transporters on the plasma membrane. Little is known about this signal transduction pathway and the role of the alpha subunit of the GM-CSF receptor (alpha GMR) in modulating transporter activity. We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex. We identified a Src homology 3 domain-binding motif in alpha GMR at residues 358-361 as a potential interaction site for the PI 3-kinase regulatory subunit, p85. Physical evidence for p85 binding to alpha GMR was obtained by co-immunoprecipitation with antibodies to alpha GMR and p85, and an alpha GMR mutant with alteration of the Src homology 3 binding domain lost the ability to bind p85. Experiments with a construct eliminating most of the intracellular portion of alpha GMR showed a 50% reduction in GM-CSF-stimulated glucose uptake with residual activity blocked by wortmannin. Searching for a proximally generated diffusible factor capable of activating PI 3-kinase, we identified hydrogen peroxide (H(2)O(2)), generated by ligand or antibody binding to alpha GMR, as the initiating factor. Catalase treatment abrogated GM-CSF- or anti-alpha GMR antibody-stimulated glucose uptake in alpha GMR-expressing oocytes, and H(2)O(2) activated PI 3-kinase and led to some stimulation of glucose uptake in uninjected oocytes. Human myeloid cell lines and primary explant human lymphocytes expressing high affinity GM-CSF receptors responded to alpha GMR antibody with increased glucose uptake. These results identify the early events in the stimulation of glucose uptake by GM-CSF as involving local H(2)O(2) generation and requiring PI 3-kinase activation. Our findings also provide a mechanistic explanation for signaling through the isolated alpha subunit of the GM-CSF receptor.
Facilitated Oxygen Transport in Poly (alkylmethacrylate-co-vinylimidazole) -cobaltporphyrin Membranes (1989)

酸素が特異的かつ可逆的に結合するコバルトポルフィリン錯体を, ポリ (アルキルメタクリレート-co-ヒニルイミダゾール) に配位固定し, 膜を作製した. 側鎖アルキル鎖長に伴いTgは低下, 膜への酸素溶解度係数が増加した. それを反映して, 分光学的測定から得られた錯体への見掛けの酸素結合平衡定数は増大した. 見掛けの酸素結合解離速度定数も, Tg低下に伴い増加した. 低真空法透過測定から求めた各膜の酸素透過係数及び遅れ時間は, 低供給圧側で増大したので, これを二元輸送モデルで解析した. 酸素透過係数はアルキル鎖長とともに増加した. これは主として酸素拡散性の増大の寄与による.
Abstract 2519: A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein (2014)

Abstract Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing's sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 would be appealing in these cancers; however, oncogenic transcription factors are often deemed “undruggable” by conventional methods. Here, we used small-molecule microarray (SMM) screens to identify and characterize drug-like compounds that modulate the biological function of ETV1. We identified the 1,3,5-triazine small molecule BRD32048 as a top candidate ETV1 perturbagen. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. Moreover, BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation. These results point to a new avenue for pharmacological ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins. Note: This abstract was not presented at the meeting. Citation Format: Marius Pop, Nicolas Stransky, Colin Garvie, Jean-Philippe Theurillat, Timothy Lewis, Cheng Zhong, Elizabeth Culyba, Fallon Lin, Douglas Daniels, Raymond Pagliarini, Lucienne Ronco, Angela Koehler, Levi Garraway. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2519. doi:10.1158/1538-7445.AM2014-2519
Chemical Interaction at the MoO₃/CH₃NH₃PbI₃–ₓClₓ Interface (2021)

The limited long-term stability of metal halide perovskite-based solar cells is a bottleneck in their drive toward widespread commercial adaptation. The organic hole-transport materials (HTMs) have been implicated in the degradation, and metal oxide layers are proposed as alternatives. One of the most prominent metal oxide HTM in organic photovoltaics is MoO₃. However, the use of MoO₃ as HTM in metal halide perovskite-based devices causes a severe solar cell deterioration. Thus, the formation of the MoO₃/CH₃NH₃PbI₃–ₓClₓ (MAPbI₃–ₓClₓ) heterojunction is systematically studied by synchrotron-based hard X-ray photoelectron spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Raman spectroscopy. Upon MoO₃ deposition, significant chemical interaction is induced at the MoO₃/MAPbI₃–ₓClₓ interface: substoichiometric molybdenum oxide is present, and the perovskite decomposes in the proximity of the interface, leading to accumulation of PbI₂ on the MoO₃ cover layer. Furthermore, we find evidence for the formation of new compounds such as PbMoO₄, PbN₂O₂, and PbO as a result of the MAPbI₃–ₓClₓ decomposition and suggest chemical reaction pathways to describe the underlying mechanism. These findings suggest that the (direct) MoO₃/MAPbI₃–ₓClₓ interface may be inherently unstable. It provides an explanation for the low power conversion efficiencies of metal halide perovskite solar cells that use MoO₃ as a hole-transport material and in which there is a direct contact between MoO₃ and perovskite.