gebhart/patrepeval huggingface dataset:
Synthesis of corrins and related ligands. I. General approach and model studies (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of corrins and related ligands. I. General approach and model studiesR. V. Stevens, C. G. Christensen, William L. Edmonson, Morris Kaplan, Edward B. Reid, and Mark P. WentlandCite this: J. Am. Chem. Soc. 1971, 93, 24, 6629–6637Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ja00753a050https://doi.org/10.1021/ja00753a050research-articleACS PublicationsRequest reuse permissionsArticle Views375Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: IR Spectroscopy at High Pressure. Interaction of N2 with Rh/Al2O3 at Ambient Temperature. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Predictors of 1-year mortality after transcatheter aortic valve replacement (2018)

Patient characteristics and procedure-related complications are both significantly associated with increased risk of death within 1 year of TAVR. Patients with the baseline findings of severe chronic lung disease or severe tricuspid valve regurgitation may not experience mortality benefit from TAVR, and they should be assessed and counselled accordingly. Avoiding procedure-related complications is paramount to a good outcome. The findings have important implications for health care delivery services.
Analysis and design of two types of microwave baluns (2002)

Theoretical analysis and experimental realization of two types of microwave baluns is presented. Both baluns are made from coupled strip lines with one input and two output ports. The power outputs from the output ports are equal and anti-phased over a certain bandwidth. Conditions for perfect balance, at least at the center frequency, are stated and parametric sensitivity analysis is given analytically.
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies (2016)

Interleukin 6 plays a key role in mediating inflammatory reactions in autoimmune diseases and cancer, where it is also involved in metastasis and tissue invasion. Neutralizing antibodies against IL-6 and its receptor have been approved for therapeutic intervention or are in advanced stages of clinical development. Here we describe the crystal structures of the complexes of IL-6 with two Fabs derived from conventional camelid antibodies that antagonize the interaction between the cytokine and its receptor. The x-ray structures of these complexes provide insights into the mechanism of neutralization by the two antibodies and explain the very high potency of one of the antibodies. It effectively competes for binding to the cytokine with IL-6 receptor (IL-6R) by using side chains of two CDR residues filling the site I cavities of IL-6, thus mimicking the interactions of Phe(229) and Phe(279) of IL-6R. In the first antibody, a HCDR3 tryptophan binds similarly to hot spot residue Phe(279) Mutation of this HCDR3 Trp residue into any other residue except Tyr or Phe significantly weakens binding of the antibody to IL-6, as was also observed for IL-6R mutants of Phe(279) In the second antibody, the side chain of HCDR3 valine ties into site I like IL-6R Phe(279), whereas a LCDR1 tyrosine side chain occupies a second cavity within site I and mimics the interactions of IL-6R Phe(229).
Long-term follow-up of late morbidity, cosmetic outcome and body image after breast conserving therapy. A study from the Danish Breast Cancer Cooperative Group (DBCG) (2012)

The majority of patients were satisfied with their cosmetic outcome after BCT, whereas only half of the patients were found to have a good or excellent cosmetic outcome when assessed by the clinician. Body image was found to be only minimally disturbed in the majority of patients. The level of moderate to severe fibrosis was acceptable compared to both national and international studies with similar patient compositions.
Compared Performance of Fresnel-Based Concentrators at Array Level (2010)

At module level (one single solar cell), the Fresnel-Köhler (FK) concentrator comprises a perfect irradiance uniformity along with quite high concentration-acceptance angle product and loose manufacturing tolerances. At the same time, it maintains the efficiency/simplicity of other Fresnel-based concentrators. All these facts, along with the pill-box shape of its transmission curve, permit an enhanced performance of this device, compared to its competitors, at array level, because the system is less sensitive to manufacturing errors and cells dispersion, and current mismatch is less likely to occur. Or the same performance can be achieved at a lower cost, exhausting the tolerance budget by using inexpensive fabrication techniques. Depending on the concentrator, the actual power delivered by an array might drop significantly with respect to the sum of the power delivered by single modules. Under certain circumstances, the FK can reach a 1-10% electrical efficiency increase with regards to other concentrators sharing the same technology.
High Quality Factor Microcavity for Van der Waals Semiconductor Polaritons Using a Transferrable Mirror (2022)

Abstract Semiconductor microcavities with a high quality‐factor are an important component for photonics research and technology, especially in the strong coupling regime. While van der Waals semiconductors have emerged as an interesting platform for photonics due to their strong exciton–photon interaction strength and engineering flexibility, incorporating them in photonic devices requires heterogeneous integration and remains a challenge. This study demonstrates a method to assemble high quality factor microcavities for van der Waals materials, using high reflectance top mirrors which, similar to van der Waals materials themselves, can be nondestructively and reliably peeled off the substrate and transferred onto the rest of the device. Microcavities are created with quality factors consistently above 2000 and up to 11000 ± 800; and the strong coupling regime is demonstrated. The method can be generalized to other types of heterogeneously integrated photonic structures and will facilitate research on cavity quantum electrodynamic and photonic systems using van der Waals materials.
Single-Donor Transport Spectroscopy in Ultimate Silicon Transistors (2013)

Downward scaling of ﬁeld-eﬀect transistors (FETs) has opened anew era where transport spectroscopy through one or few atoms(phosphorus, arsenic, boron, etc.) immersed in a small (silicon)crystal is achievable. For usual transistors single-dopant eﬀectsare detrimental, leading to an enhanced variability. But the single-atom transistor (SAT) in which the drain-source current is driventhrough gate-controlled atomic orbitals of a dopant opens newopportunities compared to the usual transistor and even artiﬁcialatom transistors. Large quantization of orbitals for quantum bits[1] and multivalued logic, single-electron eﬀects for very low-powerapplications, information manipulation, and adiabatic transfer [2]based on charge correlation without charge transfer are examples.The SAT relies on the bare potential of the donor atom. This potentialis very steep close to the donor’s atom core and less sensitive tomesoscopic details and therefore to process variability sources.
Improved annotation of the insect vector of Citrus greening disease: Biocuration by a diverse genomics community (2017)

ABSTRACT The Asian citrus psyllid ( Diaphorina citri Kuwayama) is the insect vector of the bacterium Candidatus Liberibacter asiaticus (CLas), the pathogen associated with citrus Huanglongbing (HLB, citrus greening). HLB threatens citrus production worldwide. Suppression or reduction of the insect vector using chemical insecticides has been the primary method to inhibit the spread of citrus greening disease. Accurate structural and functional annotation of the Asian citrus psyllid genome, as well as a clear understanding of the interactions between the insect and CLas, are required for development of new molecular-based HLB control methods. A draft assembly of the D. citri genome has been generated and annotated with automated pipelines. However, knowledge transfer from well-curated reference genomes such as that of Drosophila melanogaster to newly sequenced ones is challenging due to the complexity and diversity of insect genomes. To identify and improve gene models as potential targets for pest control, we manually curated several gene families with a focus on genes that have key functional roles in D. citri biology and CLas interactions. This community effort produced 530 manually curated gene models across developmental, physiological, RNAi regulatory, and immunity-related pathways. As previously shown in the pea aphid, RNAi machinery genes putatively involved in the microRNA pathway have been specifically duplicated. A comprehensive transcriptome enabled us to identify a number of gene families that are either missing or misassembled in the draft genome. In order to develop biocuration as a training experience, we included undergraduate and graduate students from multiple institutions, as well as experienced annotators from the insect genomics research community. The resulting gene set (OGS v1.0) combines both automatically predicted and manually curated gene models. All data are available on https://citrusgreening.org/ .
A multicenter phase 1 study of nivolumab for relapsed hematologic malignancies after allogeneic transplantation (2020)

Programmed cell death-1 (PD-1)/programmed death ligand-1 blockade may potentially augment graft-vs-tumor effects following allogeneic hematopoietic cell transplantation (alloHCT), but retrospective studies of anti-PD-1 therapy reported substantial toxicity from graft-versus-host-disease (GVHD). Here, we report the results of a prospective clinical trial of PD-1 blockade for relapsed hematologic malignancies (HMs) after alloHCT (NCT01822509). The primary objective in this phase 1 multicenter, investigator-initiated study was to determine maximum tolerated dose and safety. Secondary objectives were to assess efficacy and immunologic activity. Patients with relapsed HMs following alloHCT were eligible. Nivolumab was administered every 2 weeks until progression or unacceptable toxicity, starting with a 1-mg/kg cohort, with planned deescalation based on toxicity to a 0.5-mg/kg cohort. Twenty-eight patients were treated (n = 19 myeloid, n = 9 lymphoid). Median age was 57 years (range 27-76), and median time from alloHCT to enrollment was 21 months (range 5.6-108.5). Two of 6 patients treated at 1 mg/kg experienced dose-limiting toxicity (DLT) from immune-related adverse events (irAEs). Twenty-two patients were treated at 0.5 mg/kg, and 4 DLTs occurred, including 2 irAEs and 2 with fatal GVHD. The overall response rate in efficacy-evaluable patients was 32% (8/25). With a median follow-up of 11 months, the 1-year progression-free survival and overall survival were 23% and 56%, respectively. In this first prospective clinical trial of an anti-PD-1 antibody for post-alloHCT relapse, GVHD and irAEs occurred, requiring dose deescalation, with only modest antitumor activity. Further studies of anti-PD-1 therapy post-alloHCT may require specific toxicity mitigation strategies. This trial was registered at www.clinicaltrials.gov as #NCT01822509.
Laminated Fiber Ribbon for Optical Communication Cables (1976)

Laminated fiber ribbon (lamfir) exhibits mechanical properties of a composite structure and is strong enough to withstand the stresses of cable fabrication. Laminating parameters have been adjusted to make the lamfir relatively easy to separate for accessing the fibers. Optical properties of lamfir have been characterized, so that trade-offs between numerical apertures (na), cladding thickness/core diameter (t/d), and additional loss are given for uncoated, step-profile fibers and one set of laminating conditions. Larger values of t/d than originally expected are desirable due to the bends in the fiber axes.
Realizing ICN in 3GPP's 5G NextGen Core Architecture (2017)

The proposed 3GPP's 5G Next-generation (NextGen) Core architecture (5GC) enables the ability to introduce new user and control plane functions within the context of network slicing to allow greater flexibility in handling of heterogeneous devices and applications. In this paper, we discuss the integration of such architecture with future networking technologies by focusing on the information centric networking (ICN) technology. For that purpose, we first provide a short description of the proposed 5GC, which is followed by a discussion on the extensions to 5GC's control and user planes to support Protocol Data Unit (PDU) sessions from ICN. To illustrate the value of enabling ICN within 5GC, we focus on two important network services that can be enabled by ICN data networks. The first case targets mobile edge computing for a connected car use case, whereas the second case targets seamless mobility support for ICN sessions. We present these discussions in consideration with the procedures proposed by 3GPP's 23.501 and 23.502 technical specifications.
Plant-like alkaloid biosynthesis in fungi (2015)

Traditional natural products discovery efforts have focused primarily on biosynthetic genes clusters (BGCs) containing large multi-modular NRPSs; however, sequencing of fungal genomes has revealed a vast reservoir of BGCs containing smaller NRPS-like genes whose biosynthetic functions have remained elusive. Using a comparative metabolomics approach, we show that a BGC in the human pathogen Aspergillus fumigatus named fsq, which contains an NRPS-like gene, produces a family of novel isoquinoline alkaloids, the fumisoquins. Assembly of these compounds is based on an unprecedented carbon-carbon bond formation between L-serine- and L-tyrosine-derived building blocks, followed by formation of the isoquinoline ring system via a sequence that is directly analogous to the biosynthesis of an important family of isoquinoline alkaloids in plants. Fumisoquin biosynthesis requires the N-methylase FsqC and the FAD-dependent oxidase FsqB, which represent functional orthologs of coclaurine N-methyltransferase and berberine bridge enzyme in plants. Analysis of fungal genomes revealed homologs of fsq genes in many species, suggesting that plant-like isoquinoline biosynthesis is widespread in fungi. We corroborated the biosynthetic role of these fungal genes by demonstrating isoquinoline biosynthesis by a different BGC in A. flavus. Our results provide a striking example for convergent evolution of a multistep biosynthetic mechanism and show that BGCs containing NRPS-like genes may reveal new biosynthetic paradigms.
Effect of Gonadal Steroids on the Luteinizing Hormone and Follicle-Stimulating Hormone Response to 8-Bromo-Adenosine 3′,5′-Monophosphate in Anterior Pituitary Cells in Culture (1978)

-8-Bromo-cAMP stimulated the release of LH (approximately 20-fold) and FSH (approximately 2-fold) in control rat anterior pituitary cells in primary culture. 8-Bromo-cAMP-induced LH release was 2-3 times greater in cells preincubated for 48 h in the presence of 10(-8) M 17 beta-estradiol (E2). The LH response to 10(-10) M LHRH was similarly increased by E2 pretreatment whereas progesterone (P), which had no effect on the response to 8-bromo-cAMP, led to a reduction of the stimulatory effect of E2 on the LH response to the neurohormone. Preincubation with 10(-8) M testosterone (T) decreased the LH response to 8-bromo-cAMP by about 40%, whereas the response to LHRH was 80% inhibited. 8-Bromo-cAMP-induced FSH release was slightly increased in cells preincubated with E2 but was greatly augmented in cells treated with E2 + P. Basal FSH release was slightly increased (40%) after preincubation with P or T whereas the response to 8-bromo-cAMP was not significantly affected. The sensitivity of the FSH response to LHRH was increased by E2 whereas P and T led to a stimulation of the maximal FSH response to LHRH with no significant effect on the LHRH ED50 value. The present data indicate that P and E2 exert their effects on LH and FSH release at steps before and after cAMP formation, respectively. T appears to act at both steps on the release of the two gonadotropins.
Optical Coherence Microscopy (2022)

Confocal microscopy has become a standard technique for high resolution optical imaging in many fields 1,2 . Confocal imaging is conventionally limited to relatively transparent specimens, since image contrast is degraded by light scattering in turbid samples. We have developed a new method for coherent confocal microsopy which uses low-coherence interferometry to enhance optical sectioning in highly scattering media. In optical coherence microscopy (OCM), improved confocal imaging is achieved through high detection sensitivity and high contrast rejection of out-of-focus light. OCM is an adaptation of optical coherence tomography (OCT), which has recently been demonstrated for noninvasive, ten-micron-scale resolution imaging in the eye and other biological tissues 3-5 . The extension of this technique to confocal microscopy offers the potential for micron-resolution imaging deep into highly scattering media such as skin and endoscopically accessible tissues, and may make possible the development of a new form of noninvasive "optical biopsy."
HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress (2018)

Cancer testis antigens (CTA) are expressed in testis and placenta and anomalously activated in a variety of tumors. The mechanistic contribution of CTAs to neoplastic phenotypes remains largely unknown. Using a chemigenomics approach, we find that the CTA HORMAD1 correlates with resistance to the mitochondrial complex I inhibitor piericidin A in non-small cell lung cancer (NSCLC). Resistance was due to a reductive intracellular environment that attenuated the accumulation of free radicals. In human lung adenocarcinoma (LUAD) tumors, patients expressing high HORMAD1 exhibited elevated mutational burden and reduced survival. HORMAD1 tumors were enriched for genes essential for homologous recombination (HR), and HORMAD1 promoted RAD51-filament formation, but not DNA resection, during HR. Accordingly, HORMAD1 loss enhanced sensitivity to γ-irradiation and PARP inhibition, and HORMAD1 depletion significantly reduced tumor growth <i>in vivo</i> These results suggest that HORMAD1 expression specifies a novel subtype of LUAD, which has adapted to mitigate DNA damage. In this setting, HORMAD1 could represent a direct target for intervention to enhance sensitivity to DNA-damaging agents or as an immunotherapeutic target in patients.<b>Significance:</b> This study uses a chemigenomics approach to demonstrate that anomalous expression of the CTA HORMAD1 specifies resistance to oxidative stress and promotes HR to support tumor cell survival in NSCLC. <i>Cancer Res; 78(21); 6196-208. ©2018 AACR</i>.
Taking Measure of Personalized Medicine: The Proteome (2013)

Good medicine begins, by and large, with measurements. For medicine to become truly personalized, it is critical that the right measurements are made and interpreted. Although genomics holds great promise for deepening our understanding of biology, we believe that a perhaps more critical and transformative measurement for medicine is proteomics, which has lagged behind genomics for largely technological reasons. Proteins uniquely provide a real-time, clinically relevant measure of individual patients. We describe here an entirely new proteomics technology that makes the measure of proteins from biological samples as straightforward as measuring genes, and list some of the applications that have already been performed.
Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels (2021)

Hibernating mammals may suppress their basal metabolic rate during torpor by up to 95% to reduce energy expenditure during winter, but the underlying mechanisms remain poorly understood. Here we show that hydrogen sulfide (H<sub>2</sub>S), a ubiquitous signaling molecule, is a powerful inhibitor of respiration of liver mitochondria isolated from torpid 13-lined ground squirrels, but has a weak effect on mitochondria isolated during summer and hibernation arousals, where metabolic rate is normal. Consistent with these in vitro effects, we find strong seasonal variations of in vivo levels of H<sub>2</sub>S in plasma and increases of H<sub>2</sub>S levels in the liver of squirrels during torpor compared to levels during arousal and summer. The in vivo changes of liver H<sub>2</sub>S levels correspond with low activity of the mitochondrial H<sub>2</sub>S oxidizing enzyme sulfide:quinone oxidoreductase (SQR) during torpor. Taken together, these results suggest that during torpor, H<sub>2</sub>S accumulates in the liver due to a low SQR activity and contributes to inhibition of mitochondrial respiration, while during arousals and summer these effects are reversed, H<sub>2</sub>S is degraded by active SQR and mitochondrial respiration rates increase. This study provides novel insights into mechanisms underlying mammalian hibernation, pointing to SQR as a key enzyme involved in the control of mitochondrial function.
An examination of pre-activity and post-activity flexibility practices of NCAA Division I and NCAA Division III basketball coaches (2009)

The purpose of this study is to determine the pre and post activity warm-up/stretching practices of men’s collegiate basketball programs (static, ballistic, proprioceptive neuromuscular facilitation, and/or dynamic stretching) if any, and in comparing those results with current research conclusions. The study will determine if current NCAA Division I and NCAA Division III basketball programs are utilizing pre and post activity protocols that reflect up-to-date research. Eighty coaches responded to a voluntary study. The coaching respondents completed a questionnaire assessing flexibility practices in order to compare these practices with, current, scientific-based literature. The results of the study showed that flexibility is incorporated into nearly every program at both the division-I and division III levels. There is a large majority of coaches that believe stretching prevents injuries and improves performance, however the results from the study show that coaches are not following the recommended research when it comes to properly conducting flexibility practices. It is important that colleges and university basketball coaches gain a better understanding of what appropriate flexibility practices are, in order to achieve maximal benefits for their respective team members.