gebhart/patrepeval huggingface dataset:
High-cycle-life and high-loading copolymer network with potential application as a soft actuator (2019)

Thermo-responsive polymer materials are appealing in emerging fields including soft robotics, artificial muscles, and actuators. However, realising a single smart polymer material that can achieve immense strain, fast actuation, and high loading remains a challenge. We attempted to address these limitations by fabricating a thermo-responsive copolymer network structure of poly(urethane–caprolactone–siloxane). The relative concentrations of these precursors were adjusted to realise a high mechanical strength of ≥17 MPa, 100% shape fixation, and a quick shape recovery time of ≤15 s. Experimental results revealed that the soft segments largely determines the extensibility and crystallinity of the copolymer material. The thermal gradient of the soft part enables the copolymer to self-heal during shape recovery. The copolymer network was applied to a load lifting device as an artificial muscle and was able to lift 200 times its weight with a short response time of <5 s and maximum power density that was half that of mammalian skeletal muscles. With its fast actuation, high loading, and self-healing abilities, the developed thermo-activated smart copolymer material is potentially applicable to a wide range of fields such as soft robotics, biomimetic devices, and prosthetics.
Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration (2023)

Abstract Background Microglia are the resident immune cells in the brain that play a key role in driving neuroinflammation, a hallmark of neurodegenerative disorders. Inducible microglia-like cells have been developed as an in vitro platform for molecular and therapeutic hypothesis generation and testing. However, there has been no systematic assessment of similarity of these cells to primary human microglia along with their responsiveness to external cues expected of primary cells in the brain. Methods In this study, we performed transcriptional characterization of commercially available human inducible pluripotent stem cell (iPSC)-derived microglia-like (iMGL) cells by bulk and single cell RNA sequencing to assess their similarity with primary human microglia. To evaluate their stimulation responsiveness, iMGL cells were treated with Liver X Receptor (LXR) pathway agonists and their transcriptional responses characterized by bulk and single cell RNA sequencing. Results Bulk transcriptome analyses demonstrate that iMGL cells have a similar overall expression profile to freshly isolated human primary microglia and express many key microglial transcription factors and functional and disease-associated genes. Notably, at the single-cell level, iMGL cells exhibit distinct transcriptional subpopulations, representing both homeostatic and activated states present in normal and diseased primary microglia. Treatment of iMGL cells with LXR pathway agonists induces robust transcriptional changes in lipid metabolism and cell cycle at the bulk level. At the single cell level, we observe heterogeneity in responses between cell subpopulations in homeostatic and activated states and deconvolute bulk expression changes into their corresponding single cell states. Conclusions In summary, our results demonstrate that iMGL cells exhibit a complex transcriptional profile and responsiveness, reminiscent of in vivo microglia, and thus represent a promising model system for therapeutic development in neurodegeneration.
Configuration Service for Mobile Apps (2017)

Keeping pace with the market requires software to be shipped quickly, in rapid release cycles with a strong feedback loop. Managing and controlling these changes become complex, especially in the mobile world. In mobile applications, unlike in the Web world, the user chooses whether to download updates or to ignore them, and rollbacks are typically not an option. This paper describes a centralized service that supports managing configuration changes for mobile applications and their backend systems. We describe which implementation decisions we took for our configuration service and how the service was used to support context-based customization of the applications based on user segmentation.
Terahertz time-gated spectral imaging for content extraction through layered structures (2016)

Spatial resolution, spectral contrast and occlusion are three major bottlenecks for non-invasive inspection of complex samples with current imaging technologies. We exploit the sub-picosecond time resolution along with spectral resolution provided by terahertz time-domain spectroscopy to computationally extract occluding content from layers whose thicknesses are wavelength comparable. The method uses the statistics of the reflected terahertz electric field at subwavelength gaps to lock into each layer position and then uses a time-gated spectral kurtosis to tune to highest spectral contrast of the content on that specific layer. To demonstrate, occluding textual content was successfully extracted from a packed stack of paper pages down to nine pages without human supervision. The method provides over an order of magnitude enhancement in the signal contrast and can impact inspection of structural defects in wooden objects, plastic components, composites, drugs and especially cultural artefacts with subwavelength or wavelength comparable layers.
Abstract 1300: Novel thyrointegrin αvβ3 antagonist in the treatment of glioblastoma multiforme (2019)

Background: The proliferative and pro-angiogenic actions mediated by L-thyroxine, pro-inflammatory and all known growth factors in glioblastoma multiforme (GBM) are initiated at cell surface thyrointegrin αvβ3 receptors for thyroid hormone on the extracellular domain of integrin αvβ3. Thyrointegrin αvβ3 receptors are over-expressed on cancer and rapidly dividing blood vessel cells, but quiescent on normal cells. A macromolecule Polyethylene glycol-conjugated bi-TriAzole Tetraiodothyroacetic acid (P-bi-TAT) acts with high affinity (Ki 3.1 nM) and specificity for the thyrointegrin αvβ3 receptors without any significant nuclear translocation.Methods: In the present studies, three primary human GBM cells and U87 glioma cell line were implanted orthotopically or subcutaneously (s.c.) into nude mice that were treated daily for up to 21 days with P-bi-TAT at different doses. Additionally, preclinical Pharmacokinetic and Safety assessments were carried out in multiple species.Results: Pharmacokinetic profiles indicated once-a-day dosing, and safety assessment studies demonstrated high safety and tolerability at 100-fold over the anticipated human equivalent dose. Fluorescence labeled P-bi-TAT administered s.c. demonstrated high biodistribution to GBM tumor in the brain that was comparable to peripherally implanted tumor. P-bi-TAT administered daily for 10-21 days s.c. at 0.3-10 mg/kg resulted in a dose-dependent suppression of GBM tumor growth and viability monitored with IVIS imaging (p <0.001). Histopathological analysis of tumors revealed 95% loss of the vascularity of treated tumors at 10 days (p <0.001) along with extensive cellular necrosis and apoptosis, without intratumoral hemorrhage. GBM tumors had a 97% volume loss and maximal loss of GBM cell viability during a subsequent 22 days off-treatment period (p < 0.001). Genomic micro-array studies with human primary GBM revealed that over 30 pathways relevant to the progression of GBM are modulated by P-bi-TAT.Conclusions: P-bi-TAT is a promising lead clinical candidate effective in the treatment of human GBM.Citation Format: Shaker A. Mousa, Thangirala Sudha, Kavitha Godugu, Mehdi Rajabi, Stewart Sell, Paul J. Davis. Novel thyrointegrin αvβ3 antagonist in the treatment of glioblastoma multiforme [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1300.
Collaborative Robotics Toolkit (CRTK): Open Software Framework for Surgical Robotics Research (2020)

Robot-assisted minimally invasive surgery has made a substantial impact in operating rooms over the past few decades with their high dexterity, small tool size, and impact on adoption of minimally invasive techniques. In recent years, intelligence and different levels of surgical robot autonomy have emerged thanks to the medical robotics endeavors at numerous academic institutions and leading surgical robot companies. To accelerate interaction within the research community and prevent repeated development, we propose the Collaborative Robotics Toolkit (CRTK), a common API for the RAVEN-II and da Vinci Research Kit (dVRK) - two open surgical robot platforms installed at more than 40 institutions worldwide. CRTK has broadened to include other robots and devices, including simulated robotic systems and industrial robots. This common API is a community software infrastructure for research and education in cutting edge human-robot collaborative areas such as semi-autonomous teleoperation and medical robotics. This paper presents the concepts, design details and the integration of CRTK with physical robot systems and simulation platforms.
Autocorrelation method for fractal analysis in nonrectangular image domains (2013)

We report an autocorrelation-based approach that accurately measures fractal organization within arbitrarily shaped (nonrectangular) regions of interest of gray-scale images. It extends fractal analysis beyond what is possible using fast Fourier transforms and improves on a previous autocorrelation algorithm. We illustrate its use in detecting subtle changes in mitochondrial organization within murine fibroblasts expressing the human papillomavirus E7 oncogene.
Cytolytic Response to HIV in Patients with HIV Disease Treated with Extracorporeal Photochemotherapy: Preliminary Study (1996)

Extracorporeal photochemotherapy (photopheresis), an immunomodulatory therapy that targets circulating T helper lymphocytes, has been applied to the management of human immunodeficiency virus (HIV) disease. Any therapy that exerts its actions on CD4+ T cells has the potential of exacerbating HIV infection. Therefore, it was necessary to observe immune function during treatment. Because cytotoxic T lymphocytes (CTL) and natural-killer cells are thought to play an important role in the response against HIV infection, we examined the effect of photopheresis on HIV cytolytic activity. The study group consisted of seven patients with late-stage HIV disease who had not received any previous treatment for HIV infection. Patients were treated exclusively with photopheresis on two consecutive days each month for 14-32 months (average, 25 months). Peripheral lymphocytes, collected at various points during treatment, were used as effectors in a 51Cr release assay. Epstein-Barr virus (EBV)-transformed autologous B cell lines transfected with recombinant vaccinia vectors that expressed the HIV env (gp120, gp41) and gag (p24) proteins were used as target cells. All seven patients demonstrated relatively constant levels of cytolysis (>10% above controls) during treatment in the context of stable CD4+ T cell counts and a stable clinical status. These results suggest that extracorporeal photochemotherapy did not impair the cytolytic response to HIV infection and may have enhanced it in some patients.
TiOx Magneli phases as anode material for the degradation of refractory pollutants (2015)

International audience
ChemInform Abstract: ENHANCEMENT OF DECOMPOSITION QUANTUM YIELDS OF RELUCTANT AZOALKANES (1980)

Abstract Die Quantenausb.
Environmental isolation ofCryptococcus neoformansandCryptococcus gattiifrom living trees in Guindy National Park, Chennai, South India (2009)

We report for the first time the environmental isolation of Cryptococcus neoformans from decaying wood and bark debris of living trees in Guindy National Park, Chennai, South India. Of the 40 trees screened, four isolates of Cryptococcus species were recovered of which two were Cryptococcus gattii, one was C. neoformans and one was untypable. The isolation of C. neoformans from Eucalyptus globulus and C. gattii from Cassia marginata in this study constitutes the first record of the natural occurrence of C. neoformans varieties in these tree species anywhere in the world. The isolation of C. gattii from Syzygium cumini represents the first isolation from South India.
Stable Long‐Term Intracellular Labelling with Fluorescently Tagged Cationic Magnetoliposomes (2008)

Iron oxide nanocrystals that are dextran coated are widely exploited biomedically for magnetic resonance imaging (MRI), hyperthermia cancer treatment and drug or gene delivery. In this study, the use of an alternative coating consisting of a phospholipid bilayer directly attached to the magnetite core is described. The flexible nature of the magnetoliposome (ML) coat, together with the simple production procedure, allows rapid and easy modification of the coating, offering many exciting possibilities for the use of these particles in biomedical applications. Upon incubation of neutral MLs with an equimolar amount of cationic 1,2-distearoyl-3-trimethylammoniumpropane (DSTAP)-bearing vesicles, approximately one third of the cationic lipids are incorporated into the ML coat. This is in line with a theoretical model predicting transferability of only the outer leaflet phospholipids of bilayer structures. Most interestingly, the use of MLs containing 3.33 % DSTAP with a positive zeta-potential of (31.3+/-7.3) mV (mean +/-SD) at neutral pH, results in very heavy labelling of a variety of biological cells (up to (70.39+/-4.52) pg of Fe per cell, depending on the cell type) without cytotoxic effects. The results suggest the general applicability of these bionanocolloids for cell labelling. Mechanistically, the nanoparticles are primarily taken up by clathrin-mediated endocytosis and follow the endosomal pathway. The fate of the ML coat after internalisation has been studied with different fluorescent lipid conjugates, which because of the unique features of the ML coat can be differentially incorporated in either the inner or the outer layer of the ML bilayer. It is shown that, ultimately, iron oxide cores surrounded by an intact lipid bilayer appear in endosomal structures. Once internalised, MLs are not actively exocytosed and remain within the cell. The lack of exocytosis and the very high initial loading of the cells by MLs result in a highly persistent label, which can be detected, even in highly proliferative 3T3 fibroblasts, for up to at least one month (equivalent to approximately 30 cell doublings), which by far exceeds any values reported in the literature.
Frictional Behaviour of Lubricants during Deep Drawing and Ironing Processes for Zinc-Coated Steel Sheets (1996)

Frictional behaviour of lubricants during the deep drawing and the ironing processes was studied for two types of zinc-coated steel sheets at low speeds. Deep drawability of galvannealed steel sheet (GA) was significantly improved by an increase in viscosity as well as by addition of the friction modifiers, which was due to reduction in frictional forces in the flange zone and around the die radius. In contrast to the results in the drawing test, the frictional characteristics in the ironing test were little affected by the viscosity because the ironing process was primarily performed in the boundary lubrication regime. As to workpiece materials, a double-layer steel (GAE) coated with an electrogalvanized iron-rich alloy layer on the surface of GA was superior to GA in terms of deep drawability due to the lower contact ratio based on high hardness of the top coating layer and probably due to a low coefficient of friction in the boundary contact area. When compared with the effects of the friction modifiers, active sulphur EP (extreme pressure) additive showed the most significant effect on formability and the lowest friction in the ironing process. On the other hand calcium sulphonate raised formability in the deep drawing, but was ineffective for reducing friction in the ironing process.
Towards a Composable Computer System (2018)

The recent advancement of technology in both software and hardware enables us to revisit the concept of the composable architecture in the system design. The composable system design provides flexibility to serve a variety of workloads. The system offers a dynamic co-design platform that allows experiments and measurements in a controlled environment. This speeds up the system design and software evolution. It also decouples the lifecycles of components. The design consideration includes adopting available technology with the understanding of application characteristics. With the flexibility, we show the design has the potential to be the infrastructure of both cloud computing and HPC architecture serving a variety of workloads.
Wheel-Shaped Polyoxotungstate [Cu20Cl(OH)24(H2O)12-(P8W48O184)]25- Macroanions Form Supramolecular “Blackberry” Structure in Aqueous Solution [J. Am. Chem. Soc. 2006, 128, 10103−10110]. (2007)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionWheel-Shaped Polyoxotungstate [Cu20Cl(OH)24(H2O)12-(P8W48O184)]25- Macroanions Form Supramolecular "Blackberry" Structure in Aqueous Solution [J. Am. Chem. Soc.2006, 128, 10103−10110].Guang Liu, Tianbo Liu, Sib Sankar Mal, and Ulrich KortzCite this: J. Am. Chem. Soc. 2007, 129, 8, 2408Publication Date (Web):February 2, 2007Publication History Published online2 February 2007Published inissue 1 February 2007https://pubs.acs.org/doi/10.1021/ja069317ahttps://doi.org/10.1021/ja069317acorrectionACS PublicationsCopyright © 2007 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views882Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (38 KB) Get e-Alertsclose Get e-Alerts
The Path Forward for Biofuels and Biomaterials (2018)

An integrated biorefinery is an approach that optimizes the use of biomass for the production of biofuels, bioenergy and biomaterials for both short-and long-term sustainability. The advances in plant science will certainly be influenced by societal policies, land-use practices, accelerated plant domestication programmes, and research funding to develop this vision. These advances in plant sciences will need to be captured in subsequent biorefinery operations. The power of the biorefinery concept is supported by economies of scale and by efficient use of all incoming bioresources. The final component of the integrated biorefinery will become available, and the resulting residue products from the biorefinery will become a valuable resource for biopower, biofuels and biomaterial generation. Interrelated plant traits such as higher yield, altered stature, resilience to biotic and abiotic challenge, and biomass composition will increase industrial crop value in terms of biofuels and biomaterials.
Racing against unwanted isomerization (2021)

Control of relative reaction rates paves the way for ( Z )-alkene stereochemical retention
Abstract 1371: Overexpression Of Mitochondrial Transcription Factor A Protects Failing Myocardium From Oxidative Stress (2008)

Background: Reactive oxygen species (ROS) from mitochondria play a pivotal role in the pathogenesis and progression of heart failure. Mitochondrial transcription factor A (TFAM), a nucleus-encoded protein, in mitochondria promotes transcription of mitochondrial DNA (mtDNA), maintains mtDNA, and increases mtDNA copy number. We previously reported that overexpression of human TFAM ameliorated cardiac remodeling and improved survival by maintaining mitochondrial function. We investigated whether those beneficial effects result from the increase of antioxidative properties both in vivo and in vitro. Methods and Results: [in vivo study] We created myocardial infarction (MI) in wild type (WT) mice and human TFAM transgenic (TG) mice as a model of heart failure. We evaluated free radical generation by in vivo ESR on 28th day after the operation. MI size did not different between WT and MI. Overexpression of TFAM ameliorated MI-induced cardiac hypertrophy (histology) and LV dysfunction (2D echo and cath). Furthermore, the rate of signal decay in in vivo ESR, indicative of oxidative stress, was accelerated in WT-MI (0.10 ± 0.01 vs 0.19 ± 0.02/min, n=4–5, P&lt;0.01) whereas decelerated in TG-MI (0.12 ± 0.02/min; n=4, P&lt;0.01). DNA microarrays analysis of myocardium (8 weeks old, male) indicated that TG overexpressed (double or more) antioxidant relevant genes mostly encoded in nuclear DNA, such as Mthfd2 and Adh1 without affecting mitochondrial respiratory enzyme activities. [in vitro study] We measured superoxide in Hela cells using Dihydroethidium in the presence of rotenone, a complex I inhibitor. Overexpression of TFAM in Hela cells significantly reduced superoxide production (72.8 %). Conclusion: Overexpression of TFAM suppresses ROS. Such an antioxidative property of TFAM may contribute to its powerful anti-remodeling effect in failing heart.
Geologic-to-seismic Modelling for Eldfisk SOA Reservoir Characterization - An Integrated Study (2012)

Seismic imaging for the Eldfisk SOA requires a good understanding of overburden geology and detailed reservoir structure. In Eldfisk, we found that, based on well logs and seismic amplitude attributes, gas zones represented as pancake-shaped geobodies in the overburden, produce significant time sags in modeled seismic sections that are similar to sags observed on field datasets. Amplitude decays observed on the acquired seismic data also suggest that the pancake-shaped geobodies are heterogeneous, causing scattering and energy loss. The main contribution of this paper is to develop a workflow to convert geologic modeling property (e.g. porosity) to seismic velocity for 3D seismic modeling and RTM imaging. High-resolution seismic modeling and imaging are important for well planning and field development at Eldfisk. The integrated velocity model contain both geobodies constructed from the overburden and detailed geologic features such as small faults in the reservoirs. Results from the full 3D RTM and decimation studies have illustrated that receiver spacing greater than 300x300 m would produce significant artifacts in the reservoirs. Target-oriented visibility studies based on the integrated velocity model suggested that dominant energy around ~5-10km may provide imaging uplift to reservoir structures in the Eldfisk SOA.