gebhart/patrepeval huggingface dataset:
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics (2020)

Alveolar epithelial type II (AETII) cells are important for lung epithelium maintenance and function. We demonstrate that AETII cells from mouse lungs exposed to cigarette smoke (CS) increase the levels of the mitochondria-encoded non-coding RNA, mito-RNA-805, generated by the control region of the mitochondrial genome. The protective effects of mito-ncR-805 are associated with positive regulation of mitochondrial energy metabolism, and respiration. Levels of mito-ncR-805 do not relate to steady-state transcription or replication of the mitochondrial genome. Instead, CS-exposure causes the redistribution of mito-ncR-805 from mitochondria to the nucleus, which correlated with the increased expression of nuclear-encoded genes involved in mitochondrial function. These studies reveal an unrecognized mitochondria stress associated retrograde signaling, and put forward the idea that mito-ncRNA-805 represents a subtype of small non coding RNAs that are regulated in a tissue- or cell-type specific manner to protect cells under physiological stress.
Preparation of Graphene/Multi-Walled Carbon Nanotube Hybrid and its Use as Photoanodes of Dye-Sensitized Solar Cells (2011)

Abstract not Available.
Electronic structure of oxygen deficient amorphous oxide semiconductor a‐InGaZnO4–x: Optical analyses and first‐principle calculations (2008)

Abstract The cover picture of this issue of physica status solidi (c) has been taken from the article [1]. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Distributed encoding of spatial and object categories in primate hippocampal microcircuits (2015)

The primate hippocampus plays critical roles in the encoding, representation, categorization and retrieval of cognitive information. Such cognitive abilities may use the transformational input-output properties of hippocampal laminar microcircuitry to generate spatial representations and to categorize features of objects, images, and their numeric characteristics. Four nonhuman primates were trained in a delayed-match-to-sample (DMS) task while multi-neuron activity was simultaneously recorded from the CA1 and CA3 hippocampal cell fields. The results show differential encoding of spatial location and categorization of images presented as relevant stimuli in the task. Individual hippocampal cells encoded visual stimuli only on specific types of trials in which retention of either, the Sample image, or the spatial position of the Sample image indicated at the beginning of the trial, was required. Consistent with such encoding, it was shown that patterned microstimulation applied during Sample image presentation facilitated selection of either Sample image spatial locations or types of images, during the Match phase of the task. These findings support the existence of specific codes for spatial and numeric object representations in primate hippocampus which can be applied on differentially signaled trials. Moreover, the transformational properties of hippocampal microcircuitry, together with the patterned microstimulation are supporting the practical importance of this approach for cognitive enhancement and rehabilitation, needed for memory neuroprosthetics.
Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer (2018)

Abstract Despite resistance to endocrine therapies, estrogen receptor-positive (ER+) breast cancers (BC) still rely on ER. Eliminating ER by inducing its degradation with selective ER downregulators (SERD) should induce complete ablation of ER pathways. The clinical SERD fulvestrant, although it has demonstrated clinical benefits, is hampered by its poor drug properties and undesirable pharmacokinetics, undermining its optimal clinical activity. Therefore there is an unmet need for an improved therapy targeting ER. Here we describe SAR439859, a novel, nonsteroidal, orally bioavailable SERD currently in clinical trials. SAR439859 has a potent ER antagonist and ER degrading activity that translates in a robust inhibition of ER signaling in multiple ER+ breast cancer cell lines, including tamoxifen-resistant lines as well as cell lines harboring ER mutations. SAR439859 displays a broad and superior ER degradation activity across a large panel of ER+ cells. Importantly, based on its mechanism of action SAR439859 shows limited cross-resistance with other clinical SERD molecules. SAR439859 induces strong in vivo antitumor activity against a variety of BC cell lines and patient-derived xenografts, including models that harbor ERα mutations. The transcriptional profile analysis highlighted a crosstalk of ER mutant signaling and other oncogenic pathways. Interestingly, CDK4/6 inhibition by palbociclib induces partial activation of ER pathways as potential mechanism of tumor escape, which is completely abolished by the combination of SAR439859 with palbociclib. Finally, we demonstrate that SAR439859 in combination with palbociclib can lead to higher in vivo efficacy. This study highlights novel mechanism of ER degradation by SAR439859 that leads to profound inhibition of ER signaling as well as modulation of other oncogenic pathways and provides rationale for the ongoing clinical investigation of SAR439859 in ER+ breast cancer patients, both as a single agent and in combination with approved agents, such as CDK4 inhibitor. Citation Format: Monsif Bouaboula, Maysoun Shomali, Jane Cheng, Natalia Malkova, Fangxian Sun, Malvika Koundinya, Zhuyan Guo, Stephane Poirier, Mikhail Levit, Dietmar Hoffman, Hui Cao, Laurent Bestret, Francisco Adrian, Christoph Winter, Youssef El-Ahmad, Sylvie Vincent, Frank Halley, Gary McCort, Laurent Schio, Vicky Richon, Hong Cheng, Karl Hsu, Chris Soria, Patrick Cohen, Joanne Lager, Carlos Garcia-Echeverria, Laurent Debussche. SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 943.
Preparation and thermal decomposition of n-alkyl(tri-n-butylphosphine)silver(I) reagents (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and thermal decomposition of n-alkyl(tri-n-butylphosphine)silver(I) reagentsGeorge M. Whitesides, David E. Bergbreiter, and Philip E. KendallCite this: J. Am. Chem. Soc. 1974, 96, 9, 2806–2813Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ja00816a024https://doi.org/10.1021/ja00816a024research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scale-invariant localization using quasi-semantic object landmarks (2021)

Abstract This work presents Object Landmarks , a new type of visual feature designed for visual localization over major changes in distance and scale. An Object Landmark consists of a bounding box $${\mathbf {b}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>b</mml:mi></mml:math> defining an object, a descriptor $${\mathbf {q}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>q</mml:mi></mml:math> of that object produced by a Convolutional Neural Network, and a set of classical point features within $${\mathbf {b}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>b</mml:mi></mml:math> . We evaluate Object Landmarks on visual odometry and place-recognition tasks, and compare them against several modern approaches. We find that Object Landmarks enable superior localization over major scale changes, reducing error by as much as 18% and increasing robustness to failure by as much as 80% versus the state-of-the-art. They allow localization under scale change factors up to 6, where state-of-the-art approaches break down at factors of 3 or more.
Stability Analysis of the Electrical Power Generation System for a More Electric Aircraft (2018)

Modern day advancements in electrical engineering especially power generation and management has enabled the path for More Electrical Aircrafts (MEAs) and hybrid propulsion systems. The electrical power generation in aerospace system is in itself an isolated micro grid with ac and dc components operating in either series or parallel or in hybrid mode. Uninterrupted and stable operation of these systems is of utmost importance. Known stability methods based on Lyapunov are difficult to implement as generalized on-line stability assessment procedure for such complex power network. In this paper a detailed and systematic small signal stability analysis of a More Electric Aircraft electrical power generation system is presented based on the eigen value analysis. The effect of different control algorithms on the MEE/MEA power network stability is studied using the proposed method. Also, it is shown that the stability is improved by using optimal gain feed-forward information of dc-bus currents. The stability matrix for the whole operating regime is developed and the stability margin variation for different operating conditions and control variations is presented. The efficacy of the estimated stability margin for MEE/MEA power network is verified using an Opal-RT Virtual test bed for all the control configurations.
Ceramic/polymer matrix for electrode protection in electrochemical cells, including rechargeable lithium batteries (2023)

Articles and methods for forming ceramic/polymer composite structures for electrode protection in electrochemical cells, including rechargeable lithium batteries, are presented.
A finite element method for estimating the effective coupling coefficient of magnetostrictive transducers (1994)

A simple finite element method for determining the effective coupling coefficient of magnetostrictive transducers that includes the effects of both the mechanical and magnetic structure is presented. The method uses two finite element programs that are separately dedicated to mechanical and magnetic structures. An example based on a Terfenol-D driven barrel stave flextensional transducer is evaluated using the method.
An optimized blockchain solution for the IBM z14 (2018)

Blockchain is a technology that has been available for several years and has already had several generations. Multiple implementations exist. In this paper, we describe how one of them, the Hyperledger Fabric, is used today to demonstrate the wide usage of the technology for multiple markets beyond finance and cryptocurrency. The use cases highlight the relevance of security—due to the type of data and the distributed foundation of blockchain—and of system performance to enable the use cases in production. Security and performance are the base for the architecture of blockchain on the IBM LinuxONE systems. The Secure Service Container prevents tampering, and the cryptocard usage hardens the solution—and the performance optimization in the compiler, cryptoinstructions, and large caches provides the performance. These optimizations have been further extended with the IBM z14 beyond previous IBM Z generations. In this paper, we describe how a cluster topology is used to implement a high-availability service that scales dynamically from small networks to large ones using the hot plug capabilities of the IBM LinuxONE systems.
Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury (2012)

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
The Synthetic Approach for Regulatory and Metabolic Circuits (2009)

This chapter contains sections titled: Introduction Biological Oscillators Cell–Cell Communication in Bacteria Conclusion References
Wafer sampling by regression for systematic wafer variation detection (2005)

In-line measurements are used to monitor semiconductor manufacturing processes for excessive variation using statistical process control (SPC) chart techniques. Systematic spatial wafer variation often occurs in a recognizable pattern across the wafer that is characteristic of a particular manufacturing step. Visualization tools are used to associate these patterns with specific manufacturing steps preceding the measurement. Acquiring the measurements is an expensive and slow process. The number of sites measured on a wafer must be minimized while still providing sufficient data to monitor the process. We address two key challenges to effective wafer-level monitoring. The first challenge is to select a small sample of inspection sites that maximize detection sensitivity to the patterns of interest, while minimizing the confounding effects of other types of wafer variation. The second challenge is to develop a detection algorithm that maximizes sensitivity to the patterns of interest without exceeding a user-specified false positive rate. We propose new sampling and detection methods. Both methods are based on a linear regression model with distinct and orthogonal components. The model is flexible enough to include many types of systematic spatial variation across the wafer. Because the components are orthogonal, the degree of each type of variation can be estimated and detected independently with very few samples. A formal hypothesis test can then be used to determine whether specific patterns are present. This approach enables one to determine the sensitivity of a sample plan to patterns of interest and the minimum number of measurements necessary to adequately monitor the process.
Analysis of Varying Car Geometry Accuracies for Ray Tracing Simulations in Urban V2V Scenarios (2023)

Fifth Generation (5G) communications are envisioned to be an important part of future vehicle to vehicle (V2V) communications. Therefore, the characterization of V2V channels is a growing research area. Several different methods, such as ray tracing are used for the channel modeling. In this context, the geometries for the ray tracing simulations are key to obtain correct channel models. This paper focuses on the car geometries for urban scenarios, since they are one of the most important objects in urban environments. Car models with different accuracies are used, to perform ray tracing simulations, in order to assess the effect of the car accuracies on the simulations. It can be observed, that low poly car models provide the best tradeoff between computational complexity and simulation accuracy for ray tracing simulations. So the computational complexity is significantly reduced, while the simulation results are changing between 5% to 15%, depending on the scenario.
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo (2021)

An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs. Two glycogen synthase kinase-3 inhibitors (GSK-3i's), SB-216763 and tideglusib (the latter already in phase II clinical trials) that activate AKT/mTOR signaling were tested. These GSK-3i's reactivated latent HIV-1 present in blood samples from aviremic individuals on antiretroviral therapy (ART) in the absence of T cell activation, release of inflammatory cytokines, cell toxicity, or impaired effector function of cytotoxic T lymphocytes or NK cells. However, when administered <i>in vivo</i> to SIV-infected rhesus macaques on suppressive ART, tideglusib exhibited poor pharmacodynamic properties and resulted in no clear evidence of significant SIV latency reversal. Whether alternative pharmacological formulations or combinations of this drug with other classes of LRAs will lead to an effective <i>in vivo</i> latency-reversing strategy remains to be determined.<b>IMPORTANCE</b> If combined with immune therapeutics, latency reversing agents (LRAs) have the potential to reduce the size of the reservoir sufficiently that an engineered immune response can control the virus in the absence of antiretroviral therapy. We have identified a new class of LRAs that do not induce T-cell activation and that are able to potentiate, rather than inhibit, CD8+ T and NK cell cytotoxic effector functions. This new class of LRAs corresponds to inhibitors of glycogen synthase kinase-3. In this work, we have also studied the effects of one member of this drug class, tideglusib, in SIV-infected rhesus monkeys. When tested in vivo, however, tideglusib showed unfavorable pharmacokinetic properties, which resulted in lack of SIV latency reversal. The disconnect between our ex vivo and in vivo results highlights the importance of developing next generation LRAs with pharmacological properties that allow systemic drug delivery in relevant anatomical compartments harboring latent reservoirs.
Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism (2015)

The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect in cancer. Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer (CRC) growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. Halofuginone treatment of human CRC cells inhibited cell proliferation, induced the generation of reactive oxygen species and apoptosis. As expected, reduced level of NADPH was also observed, at least in part due to inactivation of glucose-6-phosphate dehydrogenase in pentose phosphate pathway upon HF treatment. Given these findings, we further investigated metabolic regulation of HF through Akt/mTORC1-mediated aerobic glycolysis and found that HF downregulated Akt/mTORC1 signaling pathway. Moreover, metabolomics delineated the slower rates in both glycolytic flux and glucose-derived tricarboxylic acid cycle flux. Meanwhile, both glucose transporter GLUT1 and hexokinase-2 in glycolysis were suppressed in CRC cells upon HF treatment, to support our notion that HF regulates Akt/mTORC1 signaling pathway to dampen glucose uptake and glycolysis in CRC cells. Furthermore, HF retarded tumor growth in nude mice inoculated with HCT116 cells, showing the anticancer activity of HF through metabolic regulation of Akt/mTORC1 in CRC.
Measurement of Interdiffusivity by Quantitative X-ray Microanalysis Using Analytical Electron Microscope in Ni-Al System (1993)

The energy dispersive X-ray microanalysis in an analytical electron microscope (AEM-EDS) which provides a high spatial resolution was used to measure interdiffusion coefficients in the Ni-Al binary system. Electron transparent thin specimens were prepared from a Ni/Ni-8 mol%Al diffusion couples. A modified technique was introduced to avoid breaking at the couple interface during preparation of thin specimens. The absorption correction required for the AlKα line was achieved by the differential X-ray absorption (DXA) method. A comparison showed that the agreement was fairly good between the results of the AEM-EDS and the electron probe microanalysis (EPMA). Thus, it was suggested that AEM-EDS can be used for the measurement of interdiffusivities as an alternative to EPMA, particularly at lower temperatures where a high spatial resolution is required. The interdiffusivities measured in this study are compared with other reported values. The interdiffusivities of this study are consistent with the impurity diffusivities of Al in Ni reported in other studies, but higher by an almost order of magnitude than the reported self-diffusivities of Ni in Ni. The diffusion periods and temperatures necessary for AEM-EDS were discussed in comparison with those for EPMA.
11,28-Bis(chloroacetyl)-6,7,9,10,12,13,15,16,23,24,26,27,29,30,32,33-hexadecahydrodibenzo[b,q][1,4,7,10,16,19,22,25,13,28]octaoxadiazacyclotriacontine (1990)

C 32 H 44 Cl 2 N 2 O 10 cristallise dans P2 1 /c avec a=10,659, b=7,109, c=22,105 A, β=90,80 o , Z=2; affinement jusqu'a R=0,043. La structure de ce compose, dont les chaines azapolyether ont une forme etendue, contient un nombre equivalent de liaisons C-C gauche et anti, remplissant la cavite formee par le macrocycle. Les groupes orthomethyleneoxy sortent beaucoup du plan des cycles benzeniques. Les cycles benzo adjacents, de molecules liees par symetrie, interagissent de facon «bord surface»
Immunotherapy for Fungal Infections (2002)

Most fungal pathogens are low-virulence organisms that seldom cause serious infections in individuals with intact immune function. However, fungal infections have emerged as a major medical problem in the second half of the 20th century. Factors that have contributed to this phenomenon are: (1) the development of therapies for cancer and autoimmune disorders that produce immune suppression as a consequence of their therapeutic effects; (2) increased use of indwelling vascular devices and invasive surgical techniques that compromise the integrity of the skin; (3) the use of broad spectrum antibacterial drugs that disrupt the host microbial flora and predispose to fungal superinfection; and (4) the epidemic of HIV infection that has resulted in many individuals with impaired immunologic function at risk for fungal infection. Fungi are notorious for producing chronic infections requiring prolonged therapy. The problems posed by fungal infections are compounded by the availability of only a few antifungal drugs that are relatively ineffective in patients with impaired immunity. In fact, many types of fungal infections in patients with impaired immune function cannot be eradicated with antifungal therapy. For example, cryptococcosis, coccidioidomycosis, and histoplasmosis are generally considered to be incurable in patients with advanced HIV infection. The major fungal infections and the conditions that predispose to them are listed in Table 1.
Extending the field of view by a scattering window (2018)

We demonstrate a technique to extend the field of view of the interferenceless coded aperture correlation holography (I-COACH) system beyond the limit imposed by the finite area of the image sensor.