gebhart/patrepeval huggingface dataset:
PERFORMANCE-DRIVEN DIMENSION ESTIMATION OF MEMORY POLYNOMIAL BEHAVIORAL MODELS FOR WIRELESS TRANSMITTERS AND POWER AMPLIFIERS (2010)

A novel approach is proposed for automated dimension estimation in memory polynomial based power ampliflers/transmitters behavioral models. This method consists of successively identifying the static nonlinearity order and memory depth of the model in accordance with a predeflned performance criterion. The proposed method is validated using a 3G Doherty power amplifler driven by various WCDMA signals. Experimental results demonstrate the robustness of the proposed successive sweep approach compared to the conventional blind simultaneous sweep approach. The proposed dimension estimation method is an enabling tool for e-cient design optimization of power ampliflers circuits to enhance their linearizability.
Bayesian Transduction (1999)

Transduction is an inference principle that takes a training sample and aims at estimating the values of a function at given points contained in the so-called working sample. Hence, transduction is a less ambitious task than induction which aims at inferring a functional dependency on the whole of input space. As a consequence, however, transduction provides a confidence measure on single predictions rather than classifiers, a feature particularly important for risk--sensitive applications. We consider the case of binary classification by linear discriminant functions (perceptrons) in kernel space. From the transductive point of view, the infinite number of perceptrons is boiled down to a finite number of equivalence classes on the working sample each of which corresponds to a polyhedron in parameter space. In the Bayesian spirit the posteriori probability of a labelling of the working sample is determined as the ratio between the volume of the corresponding polyhedron and the volume o...
Mutational load (ML) and T-cell-inflamed microenvironment as predictors of response to pembrolizumab. (2017)

1 Background: ML is associated with response to anti CTLA-4 and PD-1/L1 immunotherapies in some cancers, likely due to increased tumor antigenicity via generation of neoepitopes not subject to central immune tolerance. An IFNγ centric gene expression profile (GEP), characteristic of a T cell inflamed microenvironment, is also related to response to PD-1/PD-L1 therapies. The association between ML and outcome, and independent predictive values of ML and GEP in pembrolizumab treated patients across 21 tumor types were assessed. Methods: Whole exome and RNA sequencing were performed on FFPE specimens pooled from 2 multicohort advanced solid tumor trials (KEYNOTE 012 [n = 39] and 028 [n = 80]). The previously defined GEP score is a weighted sum of normalized expression values for 18 genes. ML and neoantigen analysis tools included GATK, MuTect and NetMHC. Statistical testing was adjusted for multiple testing. ML and GEP association was also explored in Moffitt and TCGA datasets. Results: ML and neoantigen load were significantly associated with objective response (OR) (AUROC = 0.76 and 0.78; p = 0.0036 and 0.0083, respectively). Median numbers of mutations were 180 in responders and 61 in nonresponders. The overall response rate (ORR) in all patients was 15%. At a ML cutoff of 102 (based on ROC Curve YoudenIndex), the ORR was 32.3% (prevalence 31.0%; NPV 92.8%). GEP was also significantly associated with OR (AUROC = 0.76; p = 0.0071). ML and GEP were modestly correlated (r = 0.28), consistent with associations between ML and GEP in Moffitt (r = 0.11) and TCGA databases (r = 0.29). When jointly modeled, ML was significantly associated with response (p = 0.0078) after adjusting for GEP (also significant; p = 0.0251). Data from additional patients will also be presented. Conclusions: These data show that ML and GEP are independently predictive biomarkers of response to pembrolizumab in multiple tumor types, suggesting that tumor antigenicity and T cell infiltration may provide complementary information for expected pembrolizumab activity. As measures of distinct, yet common features of a PD-1 checkpoint blockade responsive tumor, ML and GEP may have utility in characterizing responses to anti PD-1 and other cancer immunotherapies. Clinical trial information: NCT01848834; NCT02054806.
Effects of Single α-to-β Residue Replacements on Recognition of an Extended Segment in a Viral Fusion Protein (2020)

Partial replacement of α-amino acid residues with β-amino acid residues has been established as a strategy for preserving target-engagement by helix-forming polypeptides while altering other properties. The impact of β-residue incorporation within polypeptides that adopt less regular conformations, however, has received less attention. The C-terminal heptad repeat (HRC) domains of fusion glycoproteins from pathogenic paramyxoviruses contain a segment that must adopt an extended conformation in order to coassemble with the N-terminal heptad repeat (HRN) domain in the postfusion state and drive a merger of the viral envelope with a target cell membrane. Here, we examine the impact of single α-to-β substitutions within this extended N-terminal segment of an engineered HRC peptide designated VIQKI. Stabilities of hexameric coassemblies formed with the native human parainfluenza virus 3 (HPIV3) HRN have been evaluated, the structures of five coassemblies have been determined, and antiviral efficacies have been measured. Many sites within the extended segment show functional tolerance of α-to-β substitution. These results offer a basis for future development of paramyxovirus infection inhibitors with novel biological activity profiles, possibly including resistance to proteolysis.
Color Me Sensitive: Amplification and Discrimination in Photonic Silicon Nanostructures (2007)

A new paper in this issue discusses some of the considerations for fabrication of biosensor devices in the porous silicon material system. The results focus on optical detection of protease activity on specific substrates that have been immobilized in a porous silicon matrix. Solutions to important limitations of porous microsensors are presented: stabilizing the sensor against corrosion-induced zero point drift, minimizing the effects of nonspecific protein binding, and enhancing the optical response by incorporation of a catalytic reaction in the sensing scheme.
The impact of data placement on memory management for multi-server OODBMS (2002)

We demonstrate the close relationship between data placement and memory management for symmetric multi-server OODBMS. We propose and investigate memory management algorithms for two data placement strategies, namely declustering and clustering. Through a detailed simulation, we show that by declustering the data most of the benefits of complex global memory management algorithms are realized by simple algorithms. In contrast we show that when data is clustered, the simple algorithms perform poorly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis (2017)

In this study, the overall accuracy of imaging diagnosis improved to 96% when T2-guided NIRST was added to noncontrast MRI alone, relative to 88% for DCE MRI, suggesting that similar or better diagnostic accuracy can be achieved without requiring a contrast agent.
Optimal Repair of a 2-Component Series-System with Partially Repairable Components (1984)

A 2-component series system is maintained by one repairman. The up-times of the components are s-independent r.v.'s with exponential distributions. The time required to repair a failed component is the sum of a number of s-independent, exponential r.v.'s. Components can be partially repaired, and a working component can fail even while the system as a whole is not functioning. The analysis finds repairman allocation policies which maximize the system availability. Under the assumption that it is permissible to reassign the repairman instantaneously among failed components, the explicit form of optimal policies is obtained. And, the optimal policies are characterized when the time for such a reassignment is allowed to be an exponential r.v.
Photoluminescence from Single Semiconductor Nanostructures (1999)

We review some recent results in the spectroscopy of single CdSe nanocrystals quantum dots. By eliminating the effects of inhomogeneous broadening and ensemble averaging, single nanocrystal spectroscopy has revealed many new and previously unexpected physical phenomena. Among those discussed in this chapter are ultra-narrow emission lineshapes (∼ 600 × narrower than ensemble spectra), a higher polarizable emitting state in the presence of strong local electrical fields, linebroadening as a result of environmental fluctuations and shifting of the emission spectra over a wide range of energies (from less than 300 µeV to 80 meV). In addition, polarization spectroscopy of single nanocrystals has revealed the presence of a theoretically predicted 2 dimensional transition dipole moment oriented in the x-y plane of the nanocrystals. As a result, it is, in principle, possible, to use polarization spectroscopy to determine the 3 dimensional orientation of individual nanocrystals. These and other studies of single quantum dots have provided us with significant insight into the detailed physics and dynamics of this unique and fascinating physical system.
The surgeon skill set in minimally invasive total knee arthroplasty. (2006)

For select patients with persistent patellofemoral pain, the anteromedial tibial tubercle transfer (Fulkerson osteotomy) provides excellent clinical results. This procedure, indicated for patients with patellar malalignment, has become one of the most popular distal realignment procedures. One potential concern with this technique is the proximity of the posterior vascular structures during bicortical tibial drilling for screw placement. To address this concern, we measured the proximity of these structures in 7 consecutive fresh-frozen cadaveric knees. For each knee, barium was injected into the femoral artery, and anteroposterior (AP) radiographs were taken to document the location of the popliteal vessels. Next, the initial steps of the Fulkerson osteotomy were performed. Then, a lateral release and the tibial osteotomy were performed, the tubercle was advanced into position, and two 9/64-inch extralong drill bits were placed through the tubercle and the posterior tibial cortex. Repeat AP radiographs were obtained, and digital calipers were used to measure the distance from the drill bits to the popliteal vessels. The vascular structure closest to the exit point of the superior drill bit was the bifurcation of the popliteal artery (mean distance, 8.3 mm; SD, 9.3 mm; range, 0.0-21.3 mm), and in 2 knees this structure directly overlay the bifurcation on the AP radiograph; the vascular structure closest to the exit point of the inferior drill bit was the posterior tibial artery (mean distance, 9.0 mm; SD, 8.0 mm; range, 0.0-20.0 mm), and again in 2 knees the drill bit lay directly over the artery on the AP radiograph. Bicortical drilling for screw placement during the anteromedial tibial tubercle transfer procedure may come precariously close to the posterior vascular structures of the knee, so orthopedic surgeons must take extreme caution not to drill past the posterior cortex during this part of the operation.
Crack propagation in fused silica during UV and IR ns-laser illumination (1999)

No abstract prepared.
The generalized-kinetics-based equilibrium distribution function for composite particles (2003)

This work is devoted to the equilibrium distribution function for a fluid of mutually non-interacting identical composite point particles in three-dimensional physical space. The distribution function is derived within the generalized-kinetics (GK) vision from the proposed probabilistic model based on quantum-mechanical bosons and fermions. The first GK advantage is that the derivation does not involve any assumption on the interpolation between bosons and fermions whereas the resulting function provides this interpolation. The second GK advantage is that composons, the particles described with the GK-based distribution function, are considerably less schematic and more consistent physically than quons. Composons correspond to a specific case of Isakov's general q -commutation relation involving an infinite number of the q -coefficients. Connection of the composon concept to previous results in the literature is pointed out. A few directions for future research on the topic are formulated. The results of the work can be used in the composite-particle fluid problems where the Maxwell–Boltzmann description is not valid, for instance, in dense populations of not too massive point-like particles of a complex, composite nature at not too high temperatures.
Quetiapine-Induced Hypomania and its Association with Quetiapine/Norquetiapine Plasma Concentrations: A Case Series of Bipolar Type 2 Patients (2017)

International guidelines consider quetiapine at medium doses (300-400 mg/day) as valid options for the treatment of bipolar depression for the supposed lower risk of a switch to hypomania/mania than antidepressants. Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode. Quetiapine and norquetiapine plasma concentrations were measured after 1 week of treatment. Hypomania appeared after 7-10 days of quetiapine extended-release monotherapy and all subjects had a quetiapine/norquetiapine plasma concentration ratio <1. We propose a ratio value <1 as a predictor of risk for a switch to hypomania in bipolar depressed subjects receiving quetiapine extended-release monotherapy. Future research should ascertain the validity of this laboratory parameter to assess the risk of quetiapine-induced hypomania in large samples of bipolar patients.
ChemInform Abstract: ISOXAZOLES AS β‐DIKETONE SYNTHONS. SELECTIVE ANION FORMATION ON 3,5‐DIALKYLISOXAZOLES (1982)

Abstract Acetylaceton (I) wird mit Hydroxylamin zum Dimethylisoxazol (II) cyclisiert, das mit Butyllithium und elektrophilen Reagentien zu den Verbindungen (III) und weiter zu den ggf. unsymmetrisch substituierten Produkten (IV) umgesetzt werden kann.
<title>Experimental tests of a two-layer Monte Carlo-diffusion hybrid model for photon migration in the frequency domain</title> (2001)

We examine the ability to recover the optical properties of a two-layer turbid medium using multi-distance frequency domain reflectance measurements and a hybrid Monte Carlo-- diffusion model. Frequency domain measurements are performed on two-layer liquid tissue phantoms simulating skin on muscle and skin on fat. Particular care to systematic effects in the photomultiplier is required for the measurements at short source-detectors distances. The model converges when fitting five free parameters (the optical properties of the upper and lower layers and the upper layer thickness). However, discrepancies between experimental and model yield insufficient accuracy for the absorption coefficient of the upper layer.
Low-threshold oxide-confined 1.3-μm quantum-dot laser (2000)

Data are presented on low threshold, 1.3-μm oxide-confined InGaAs-GaAs quantum dot lasers. A very low continuous-wave threshold current of 1.2 mA with a threshold current density of 28 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is achieved with p-up mounting at room temperature. For slightly larger devices the continuous-wave threshold current density is as low as 19 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Fluorescent Probes of Chromosomal DNA Structure: Three Classes of Acridines (1974)

Acridine dyes have been used extensively as fluorescent stains in cytological studies. Acridine orange has been particularly useful because of the general brilliant yellow-green fluorescence which is imparted to chromosomes when it is bound. An important technical advance in this area came from studies of Caspersson et al. (1968) who found that chromosome preparations treated with quinacrine mustard displayed high fluorescent intensity in localized regions. By this method, for example, the long arms of the human Y chromosome are rendered highly fluorescent and a Y-body can even be visualized in interphase nuclei (Pearson et al., 1970; Caspersson et al., 1970b). Because of the reactivity of mustards with the N-7 position of guanine, an affinity label model was proposed by Caspersson et al. (1968). It was postulated that quinacrine mustard specifically stained chromosome regions rich in GC base pairs, that the specificity resided in the side chain of quinacrine, and that...
Role of mitogen‐activated protein kinase kinase in Porphyromonas gingivalis‐induced myocardial cell hypertrophy and apoptosis (2006)

Secreted factors present in the medium following growth of the periodontal pathogen Porphyromonas gingivalis cause increased cardiomyocyte hypertrophy and apoptosis, whereas secreted factors from Actinobacillus actinomycetemcomitans and Prevotella intermedia have no such effects. The purpose of this study was to clarify the role of mitogen-activated protein kinase (MAPK)/extracellular-regulated protein kinase (ERK) pathways in P. gingivalis medium-induced H9c2 myocardial cell hypertrophy and apoptosis. Cellular morphology, DNA fragmentation, nuclear condensation, total mitogen-activated protein kinase/extracellular-regulated protein kinase-1 (ERK-1), total ERK-1 protein, and phosphorylated ERK-1 protein products in cultured H9c2 myocardial cells were measured by actin immunofluorescence, agarose gel electrophoresis, nuclear condensation, and western blotting following stimulation with P. gingivalis spent growth medium or pre-administration of U0126, a potent MEK-1/2 inhibitor. Components of P. gingivalis spent culture medium not only resulted in increased total MEK-1 and ERK-1 protein products, but also caused increased cellular size, DNA fragmentation, and nuclear condensation in H9c2 cells. These three parameters, and the phosphorylated ERK-1 protein products of H9c2 cells treated with P. gingivalis medium, were all significantly reduced after pre-administration of U0126. The results suggest that P. gingivalis-secreted factors may initiate MEK/ERK signal pathways and lead to myocardial cell hypertrophy and apoptosis.
Crystal structure and substrate interactions of an unusual fungal non-CBM carrying GH26 endo-β-mannanase from Yunnania penicillata (2019)

Abstract Endo- β (1 → 4)-mannanases (endomannanases) catalyse degradation of β -mannans, an abundant class of plant polysaccharides. This study investigates structural features and substrate binding of Ypen Man26A, a non-CBM carrying endomannanase from Yunnania penicillata . Structural and sequence comparisons to other fungal family GH26 endomannanases showed high sequence similarities and conserved binding residues, indicating that fungal GH26 endomannanases accommodate galactopyranosyl units in the −3 and −2 subsites. Two striking amino acid differences in the active site were found when the Ypen Man26A structure was compared to a homology model of Wsp .Man26A from Westerdykella sp . and the sequences of nine other fungal GH26 endomannanases. Two Ypen Man26A mutants, W110H and D37T, inspired by differences observed in Wsp .Man26A, produced a shift in how mannopentaose bound across the active site cleft and a decreased affinity for galactose in the −2 subsite, respectively, compared to Ypen Man26A. Ypen Man26A was moreover found to have a flexible surface loop in the position where Pans Man26A from Podospora anserina has an α -helix (α9) which interacts with its family 35 CBM. Sequence alignment inferred that the core structure of fungal GH26 endomannanases differ depending on the natural presence of this type of CBM. These new findings have implications for selecting and optimising these enzymes for galactomannandegradation.
Adaptive Sampling Algorithm for Accurate Modeling of General Interconnection Structures (1999)

A new adaptive technique is presented for building multidimensional parameterized analytical models for planar interconnection structures with a pre-defined accuracy and based on full-wave electromagnetic (EM) simulations. The models can be incorporated in a circuit simulator and the time required to calculate the circuit representation of a practical network is reduced by several orders of magnitude compared to full EM simulations. Furthermore, the accuracy of the results is significantly better compared to the results obtained with the circuit models used in state of the art CAD tools.
Novel bis-C60 derivative compared to other fullerene bis-adducts in high efficiency polymer photovoltaic cells (2011)

We report the application of novel mono- and bis-o-quino-dimethane C60 (oQDMC60) adducts in bulk heterojunction photovoltaic devices. When blended with poly(3-hexylthiophene), the fullerene adducts presented here have an enhanced open-circuit voltage of 640 mV and 820 mV, while preserving high short-circuit current and fill factor, resulting in efficiencies of 4.1% and 5.2%, respectively. Detailed assessment of material properties relevant to photovoltaic devices such as energy levels, charge carrier mobility, absorption and solubility further complements the evaluation. Increased fullerene solubility hindering phase segregation in blends with bis-oQDMC60 has been circumvented by an in-depth morphology optimization assisted by absorption spectroscopy, X-ray reflectivity and atomic force microscopy. This optimized preparation could also serve as a guide for implementation of similar fullerene derivatives. Furthermore, we compare bis-oQDMC60 to previously reported fullerene bis-adducts to provide insight into this emerging class of materials.
Effects of rubbing angle on maximum transmittance of in‐plane switching liquid crystal display (2008)

Measurements of the maximum transmittance of an in‐plane switching liquid crystal display showed that it increases as rubbing angle is increased from 10 to 20°. This dependence was analysed in terms of the local variation of electric field intensity between electrodes, which in turn makes liquid crystal at various positions between the electrodes rotate to different angles. The local variation of electric field becomes prominent, especially in the case that the distance between the electrodes is much larger than the cell gap or electrode width.
Human and Machine Type Communications Can Coexist in Uplink Massive Mimo Systems (2018)

Future cellular networks are expected to support new communication paradigms such as machine-type communication (MTC) services along with human-type communication (HTC) services. This requires base stations to serve a large number of devices in relatively short channel coherence intervals which renders allocation of orthogonal pilot sequence per-device approaches impractical. Furthermore, the stringent power constraints, place-and-play type connectivity and various data rate requirements of MTC devices make it impossible for the traditional cellular architecture to accommodate MTC and HTC services together. Massive multiple-input-multiple-output (MaMIMO) technology has the potential to allow the coexistence of HTC and MTC services, thanks to its inherent spatial multiplexing properties and low transmission power requirements. In this work, we investigate the performance of a single cell under a shared physical channel assumption for MTC and HTC services and propose a novel scheme for sharing the time-frequency resources. The analysis reveals that MaMIMO can significantly enhance the performance of such a setup and allow the inclusion of MTC services into the cellular networks without requiring additional resources.