gebhart/patrepeval huggingface dataset:
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase (2021)

The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacillus are colonizers of human mucosa and can produce compounds with bioactivity against C. albicans. Here, we show that some Lactobacillus species produce a small molecule under laboratory conditions that blocks the C. albicans yeast-to-filament transition, an important virulence trait. It remains unexplored whether the compound is produced in the context of the human host. Bioassay-guided fractionation of Lactobacillus-conditioned medium linked this activity to 1-acetyl-β-carboline (1-ABC). We use genetic approaches to show that filamentation inhibition by 1-ABC requires Yak1, a DYRK1-family kinase. Additional biochemical characterization of structurally related 1-ethoxycarbonyl-β-carboline confirms that it inhibits Yak1 and blocks C. albicans biofilm formation. Thus, our findings reveal Lactobacillus-produced 1-ABC can prevent the yeast-to-filament transition in C. albicans through inhibition of Yak1.
Processing, crystallization behavior and dielectric performance of perovskite LaTiOxNy thin films (2012)

International audience
A FULL SCALE STATIC LOADING TEST ON FIVE STORY REINFORCED CONCRETE BUILDING UTILIZING COLUMNS WITH WING WALLS (2016)

The paper shows the static loading test results on full-scale reinforced concrete building utilizing columns with wing walls. The specimen is a five-story reinforced concrete building with 1×2 bays and height of about 19m. The wall frame has large openings in longitudinal direction. The gaps was formed along the edge of wing walls to make a frame consisting of columns with wing wall and beams. Attached wing walls works as a rigid zones of soften beams and additional column section, and the specimen shows calculated strength of beam side sway mechanism. The moment curvature distribution of the 1st story wing wall frames are evaluated experimentally in the test. The inflection point derived from the interpolation between moment resisting frame and wall frames approximates the test results. The residual crack width of the beam elements becomes large for the damage concentration on the local hinge region. The damage levels evaluated from the hysteresis is smaller than that evaluated from residual crack width in the test.
Abstract 5453: YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model. (2013)

Abstract Chromosomal translocations involving the ETS family of transcription factors are found in a majority of prostate cancers, including the most clinically aggressive forms. These translocations produce a chimeric gene, which fuses the promoter region of an androgen responsive gene to the coding region of ETS factors, most frequently ETV1 or ERG. Over-expression of ETS factors in prostate cancer cells results in a more invasive phenotype. The high prevalence of these rearrangements, and their biological significance represents a novel therapeutic target for the treatment of prostate cancer. We recently demonstrated that the small molecule YK-4-279 inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells leading to decreased motility and invasion in-vitro. Here we present our findings in an in-vivo mouse xenograft model. SCID-beige mice were subcutaneously injected with LNCaP and PC-3 xenografts. Mice were treated with YK-4-279 and its effect on primary tumor size and lung metastasis was observed. YK-4-279 treatment resulted in reduced metastasis of the tumor from primary site to lungs. YK-4-279 also affected expression of ETV1 target genes such as MMP7 and MMP13. ETS fusion-negative PC-3 xenografts were unresponsive to YK-4-279. Our results demonstrate that YK-4-279 decreases tumor growth and inhibits metastasis in fusion-positive prostate cancer cell xenografts. Therefore, YK-4-279 may have an impact on preventing metastasis in prostate cancer patients, which is a leading cause of death. Citation Format: Said Rahim, Sarah Justvig, Sung-Hyeok Hong, Yali Kong, Milton L. Brown, Colm Morrissey, Jeffrey A. Toretsky, Aykut Uren. YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5453. doi:10.1158/1538-7445.AM2013-5453
Efficient policing for screen mirroring traffic (2018)

Abstract The greediness of multimedia applications in terms of their bandwidth demands calls for new and efficient network traffic control mechanisms, especially in wireless networks where the bandwidth is limited. In an enterprise-like environment, an additional burden is expected to be added to the network by screen mirroring traffic. Smart mobile devices are displacing personal computers in many daily applications but at the same time users still need to use a large display, keyboard and mouse. Hence, the transmission of low-latency, high fidelity video over a Wi-Fi link can lead to significant unfairness among users in terms of the bandwidth that is available to them, if this wireless video traffic is not accurately policed. In this work, we focus on the problem of policing screen mirroring traffic. We evaluate various classic and new traffic policing mechanisms, and we propose a new mechanism which is shown to clearly outperform all other mechanisms, including the widely used token bucket policer.
The Bulk van der Waals Layered Magnet CrSBr is a Quasi-1D Material (2023)

Correlated quantum phenomena in one-dimensional (1D) systems that exhibit competing electronic and magnetic order are of strong interest for the study of fundamental interactions and excitations, such as Tomonaga-Luttinger liquids and topological orders and defects with properties completely different from the quasiparticles expected in their higher-dimensional counterparts. However, clean 1D electronic systems are difficult to realize experimentally, particularly for magnetically ordered systems. Here, we show that the van der Waals layered magnetic semiconductor CrSBr behaves like a quasi-1D material embedded in a magnetically ordered environment. The strong 1D electronic character originates from the Cr-S chains and the combination of weak interlayer hybridization and anisotropy in effective mass and dielectric screening, with an effective electron mass ratio of <i>m</i><sub><i>X</i></sub><sup>e</sup>/<i>m</i><sub><i>Y</i></sub><sup>e</sup> ∼ 50. This extreme anisotropy experimentally manifests in strong electron-phonon and exciton-phonon interactions, a Peierls-like structural instability, and a Fano resonance from a van Hove singularity of similar strength to that of metallic carbon nanotubes. Moreover, because of the reduced dimensionality and interlayer coupling, CrSBr hosts spectrally narrow (1 meV) excitons of high binding energy and oscillator strength that inherit the 1D character. Overall, CrSBr is best understood as a stack of weakly hybridized monolayers and appears to be an experimentally attractive candidate for the study of exotic exciton and 1D-correlated many-body physics in the presence of magnetic order.
Activating supports for metallocene catalysis (2010)

US Patent 7,759,271
2-C-Azidomethyl-2-deoxy-3,4-O-isopropylidene-D-ribono-1,5-lactone (2005)

X-ray crystallographic analysis firmly establishes the ribo stereochemistry and the unusual boat conformation of the title branched carbon chain lactone, C9H13N3O4, arising from an unexpected rearrangement in the nucleophilic substitution of a trifluoromethanesulfonate. There are two molecules in the asymmetric unit. © 2006 International Union of Crystallography Printed in Great Britain - all rights reserved.
Insulin Resistance and Insulin Secretion Are Determinants of Oral Glucose Tolerance in Normal Individuals (1993)

Plasma glucose values after oral glucose challenge vary widely in nondiabetic subjects. We have now evaluated the role of insulin resistance in determining the plasma glucose response to oral glucose in 74 volunteer subjects with normal glucose tolerance. In these subjects, we determined the plasma glucose and insulin responses over a 3-h period to a 75-g oral glucose challenge, and the steady-state plasma glucose concentration during a continuous infusion of somatostatin, glucose, and insulin (a quantitative measure of insulin resistance). The plasma glucose response was defined as the incremental increase in plasma glucose concentration above the fasting value for 3 h after the oral glucose challenge. Multiple regression analysis was used to define the relationship between the dependent variable (plasma glucose response) and various predictors of this response. These analyses indicated that both the steady-state plasma glucose and the incremental insulin response during the first 30 min after the glucose load were significant predictors of the plasma glucose response. In those individuals in whom insulin action was impaired and the 30-min plasma insulin response was decreased, plasma glucose values reached higher levels. When standardized regression coefficients were determined, the incremental glucose response was directly correlated with steady-state plasma glucose (r = 0.700, P < 0.001) and inversely with the insulin response during the first 30 min (r = 0.268, P = 0.023). Furthermore, the correlation between steady-state plasma glucose and glucose response was significantly greater (P < 0.005) than that between the glucose response and 30-min insulin concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
Medicinal Applications of Cyanoacrylate (2011)

This chapter contains sections titled: Introduction Current Need in Modern Surgical Approaches Important Applications of Cyanoacrylates Surgical Applications of Cyanoacrylate Adhesives Conclusion References
A Complementary Role for the Tetraspanins CD37 and Tssc6 in Cellular Immunity (2010)

The cooperative nature of tetraspanin-tetraspanin interactions in membrane organization suggests functional overlap is likely to be important in tetraspanin biology. Previous functional studies of the tetraspanins CD37 and Tssc6 in the immune system found that both CD37 and Tssc6 regulate T cell proliferative responses in vitro. CD37(-/-) mice also displayed a hyper-stimulatory dendritic cell phenotype and dysregulated humoral responses. In this study, we characterize "double knockout" mice (CD37(-/-)Tssc6(-/-)) generated to investigate functional overlap between these tetraspanins. Strong evidence for a cooperative role for these two proteins was identified in cellular immunity, where both in vitro T cell proliferative responses and dendritic cell stimulation capacity are significantly exaggerated in CD37(-/-)Tssc6(-/-) mice when compared with single knockout counterparts. Despite these exaggerated cellular responses in vitro, CD37(-/-)Tssc6(-/-) mice are not more susceptible to autoimmune induction. However, in vivo responses to pathogens appear poor in CD37(-/-)Tssc6(-/-) mice, which showed a reduced ability to produce influenza-specific T cells and displayed a rapid onset hyper-parasitemia when infected with Plasmodium yoelii. Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity.
Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice (2022)

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also express signature genes detected in skin-resident, postmitotic Merkel cells, including atonal bHLH transcription factor 1 (ATOH1), which is required for Merkel cell development from epidermal progenitors. We now report the use of in vivo cellular reprogramming, using ATOH1, to drive MCC development from murine epidermis. We generated mice that conditionally expressed MCPyV TAgs and ATOH1 in epidermal cells, yielding microscopic collections of proliferating MCC-like cells arising from hair follicles. Immunostaining of these nascent tumors revealed p53 accumulation and apoptosis, and targeted deletion of transformation related protein 53 (Trp53) led to development of gross skin tumors with classic MCC histology and marker expression. Global transcriptome analysis confirmed the close similarity of mouse and human MCCs, and hierarchical clustering showed conserved upregulation of signature genes. Our data establish that expression of MCPyV TAgs in ATOH1-reprogrammed epidermal cells and their neuroendocrine progeny initiates hair follicle-derived MCC tumorigenesis in adult mice. Moreover, progression to full-blown MCC in this model requires loss of p53, mimicking the functional inhibition of p53 reported in human MCPyV-positive MCCs.
Integrating Terrestrial and Non-Terrestrial Networks: 3D Opportunities and Challenges (2022)

Integrating terrestrial and non-terrestrial networks has the potential of connecting the unconnected and enhancing the user experience for the already-connected, with technological and societal implications of the greatest long-term significance. A convergence of ground, air, and space wireless communications also represents a formidable endeavor for the mobile and satellite communications industries alike, as it entails defining and intelligently orchestrating a new 3D wireless network architecture. In this article, we present the key opportunities and challenges arising from this revolution by presenting some of its disruptive use cases and key building blocks, reviewing the relevant standardization activities, and pointing to open research problems. By considering two multi-operator paradigms, we also showcase how terrestrial networks could be efficiently re-engineered to cater for aerial services, or opportunistically complemented by non-terrestrial infrastructure to augment their current capabilities.
Surface intermediates in selective olefin oxidation and ammoxidation (1983)

An investigation of the mechanism of the oxidation and ammoxidation of propylene was made. The products of the above reactions were acrylonitrile and acrolein for ammoxidation and oxidation, respectively. Also, the ammoxidation and oxidation of allyl alcohol, allyl amine, and their allylic deuterium substituted analogues was studied. It was concluded that oxidation and ammoxidation of propylene have the same rate determining step. Other conclusions about the reaction intermediates were also made.
Off-axis low-coherence interferometry for surface topology measurement (2010)

In this communication we introduce a low or reduced coherence interferometry technique that can be used to retrieve surface topology on samples with high roughness. Moreover, we will show that the approach enables surface topology measurement also at the interface of so-called turbid media, where multiple scattering inside tissues can be a major issue, preventing accurate measurements.
Biobattery: Integrated Heat and Power from Biomass Residues as a Contribution to the European Energy Transition (2015)

The energy supply from renewable sources, such as wind and solar is subject to severe fluctuations. New technology is sought-after so that energy can be stored in time-independent and transportable manner. Even for renewable sources, it is important to use them effectively. At this point, the concept of the Biobattery takes hold, which was developed by the Fraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT.
Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)

<b>Textural analysis demonstrates increased heterogeneity of [<sup>18</sup>F]-FDG uptake in normal lung (on CT) in patients with IPF. Molecular imaging of the lungs using PET can be used to study early disease in IPF before CT abnormalities are apparent.</b>http://ow.ly/T82W30lGU0X
The Duality in Spatial Stiffness and Compliance as Realized in Parallel and Serial Elastic Mechanisms (2000)

Spatial elastic behavior is characterized by a 6×6 positive definite matrix, the spatial stiffness matrix, or its inverse, the spatial compliance matrix. Previously, the structure of a spatial stiffness matrix and its realization using a parallel elastic system have been addressed. This paper extends those results to the analysis and realization of a spatial compliance matrix using a serial mechanism and identifies the duality in spatial stiffness and compliance associated with parallel and serial elastic mechanisms. We show that, a spatial compliance matrix can be decomposed into a set of rank-1 compliance matrices, each of which can be realized with an elastic joint in a serial mechanism. To realize a general spatial compliance, the serial mechanism must contain joints that couple the translational and rotational motion along/about an axis. The structure of a spatial compliance matrix can be uniquely interpreted by a 6-joint serial elastic mechanism whose geometry is obtained from the eigenscrew decomposition of the compliance matrix. The results obtained from the analysis of spatial compliant behavior and its realization in a serial mechanism are compared with those obtained for spatial stiffness behavior and its realization in a parallel mechanism.
Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord (2009)

The human spinal cord contains segregated sensory and motor pathways that have been difficult to quantify using conventional magnetic resonance imaging (MRI) techniques. Multiple sclerosis is characterized by both focal and spatially diffuse spinal cord lesions with heterogeneous pathologies that have limited attempts at linking MRI and behaviour. We used a novel magnetization-transfer-weighted imaging approach to quantify damage to spinal white matter columns and tested its association with sensorimotor impairment. We studied 42 participants with multiple sclerosis who each underwent MRI at 3 Tesla and quantitative tests of sensorimotor function. We measured cerebrospinal-fluid-normalized magnetization-transfer signals in the dorsal and lateral columns and grey matter of the cervical cord. We also measured brain lesion volume, cervical spinal cord lesion number and cross-sectional area, vibration sensation, strength, walking velocity and standing balance. We used linear regression to assess the relationship between sensorimotor impairment and MRI abnormalities. We found that the dorsal column cerebrospinal-fluid-normalized magnetization-transfer signal specifically correlated with vibration sensation (R = 0.58, P < 0.001) and the lateral column signal with strength (R = -0.45, P = 0.003). Spinal cord signal measures also correlated with walking and balance dysfunction. A stepwise multiple regression showed that the dorsal column signal and diagnosis subtype alone explained a significant portion of the variance in sensation (R(2) = 0.54, P < 0.001), whereas the lateral column signal and diagnosis subtype explained a significant portion of the variance in strength (R(2) = 0.30, P < 0.001). These results help to understand the anatomic basis of sensorimotor disability in multiple sclerosis and have implications for testing the effects of neuroprotective and reparative interventions.
The VersaKey framework: versatile group key management (1999)

Middleware supporting secure applications in a distributed environment faces several challenges. Scalable security in the context of multicasting or broadcasting is especially hard when privacy and authenticity is to be assured to highly dynamic groups where the application allows participants to join and leave at any time. Unicast security is well-known and has widely advanced into production state. But proposals for multicast security solutions that have been published so far are complex, often require trust in network components, or are inefficient. In this paper, we propose a framework of new approaches for achieving scalable security in IP multicasting. Our solutions assure that newly joining members are not able to understand past group traffic and that leaving members may not follow future communication. For versatility, our framework supports a range of closely related schemes for key management, ranging from tightly centralized to fully distributed, and even allows switching between these schemes on-the-fly with low overhead. Operations have low complexity [O(log N) for joins or leaves], thus granting scalability even for very large groups. We also present a novel concurrency-enabling scheme, which was devised for fully distributed key management. In this paper, we discuss the requirements for secure multicasting, present our flexible system, and evaluate its properties based on the existing prototype implementation.
A hybrid biometric system using touch-panel-based finger-vein identification and deformable-registration-based face identification (2014)

A hybrid biometric system, which is combined with a touch-panel-based finger-vein-identification device and a deformable-registration-based face-identification module, is proposed. For this system, the touch-panel-based device is developed for access control at a facility. For finger-vein identification, a user only needs to touch the device screen. At the same time, face images of the user are acquired and enrolled in the face-identification module. Access control and surveillance inside the facility are performed by the face-identification module. The touch-panel-based device can not only provide high-accuracy authentication but also greatly reduce the user's burden during finger-vein-pattern acquisition. Furthermore, a face-alignment and identification algorithm based on deformable registration is proposed. A performance evaluation of the proposed hybrid biometric system demonstrated that the system can provide biometric authentication with both high reliability and user convenience.
Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors (1994)

To achieve gene delivery to sensory neurons of the trigeminal ganglion, thymidine kinase-negative (TK-) herpes simplex viruses (HSV) containing the reporter gene lacZ (the gene for E. coli beta-galactosidase) downstream of viral (in vectors RH116 and tkLTRZ1) or mammalian (in vector NSE-lacZ-tk) promoters were inoculated onto mouse cornea and snout. Trigeminal ganglia were removed 4, 14, 30, and 60 days after inoculation with vectors and histochemically processed with 5-bromo-4-chloro-3 indolyl-beta-galactoside (X-Gal). With vector tkLTRZ1, large numbers of labeled neurons were observed in rostromedial and central trigeminal ganglion at 4 days after inoculation. A gradual decline in the number of labeled neurons was observed with this vector at subsequent time points. With vectors RH116 and NSE-lacZ-tk, smaller numbers of labeled neurons were seen at 4 days following inoculation than were observed with vector tkLTRZ1. No labeled neurons could be observed at 14 days after inoculation with vectors RH116 and NSE-lacZ-tk. Immunocytochemistry for E. coli beta-galactosidase and in situ hybridization to HSV latency-associated transcripts revealed labeled neurons in regions of the trigeminal ganglion similar to that observed with X-Gal staining. A comparable distribution of labeled neurons in trigeminal ganglion was also observed after application of the retrograde tracer Fluoro-Gold to mouse cornea and snout. These data provide evidence that retrogradely transported tk- herpes virus vectors can be used to deliver a functional gene to sensory neurons in vivo in an anatomically predictable fashion.