gebhart/patrepeval huggingface dataset:
Generation of single frequency highly coherent high-order Laguerre-Gaussian mode with VECSELs (2012)

International audience
<i>Brugia malayi</i> L3 larvae <i>in vitro</i> killing assays. (2016)

&lt;p&gt;&lt;i&gt;Brugia malayi&lt;/i&gt; L3 larvae &lt;i&gt;in vitro&lt;/i&gt; killing assays.&lt;/p&gt;
Effective work function modulation of SWCNT–AZO NP hybrid electrodes in fully solution-processed flexible metal-oxide thin film transistors (2015)

Schematic diagram of an SWCNT–AZO NP hybrid electrode TFT and the optical image of the TFT with the SWCNT/AZO NP hybrid electrodes on a PI substrate.
An Injury Severity-, Time Sensitivity-, and Predictability-Based Advanced Automatic Crash Notification Algorithm Improves Motor Vehicle Crash Occupant Triage (2016)

The algorithm could be incorporated into vehicles to inform emergency personnel of recommended motor vehicle crash triage decisions. Lower under- and overtriage was achieved, and nationwide implementation of the algorithm would yield improved triage decision making for an estimated 165,000 occupants annually.
Nonvolatile solid-electrolyte switch embedded into Cu interconnect (2006)

A solid-electrolyte switch (ldquoNanoBridgerdquo) has been successfully embedded into a 0.13-mum-node dual-damascene Cu interconnect using a highly reliable bilayer solid-electrolyte (TaSiO/Ta2O5) and a thin oxidation barrier, resulting in an excellent ON/OFF ratio (> 109) at a low ON resistance of 50Omega. The newly developed bilayer solid-electrolyte has improved the thermal stability during the BEOL process as well as improved electrical breakdown. The CMOS compatible NanoBridge is a promising switch to achieve high-performance and low-cost programmable LSIs.
Disease- and Treatment-related Complications in Older Patients With Inflammatory Bowel Diseases: Comparison of Adult-onset vs Elderly-onset Disease (2020)

Patients with AO-IBD have lower risk of treatment-related complications as they age compared with patients with EO-IBD, without a significant difference in risk of disease-related complications.
Synthesis of biomass-supported CuNi zero-valent nanoparticles through wetness co-impregnation method for the removal of carcinogenic dyes and nitroarene (2020)

Abstract Stabilization of zero-valent CuNi nanoparticles (NPs) supported on Cicer arietenum (CP) is reported here for the reduction and removal of persistent organic pollutants. The functional groups and interactions of NPs with the CP were determined by ATR-FTIR. The crystallinity, morphology, and the elemental composition of the samples were determined through powder XRD, FESEM, and EDS techniques, respectively. The XRD spectrum displayed a sharp crystalline peak at 43.9 for CuNi. The Cu and Ni zero-valent NPs displayed a peak at almost the same region, and thus, both the peaks are merged and appeared as a single peak. The chemical reduction/degradation of eight model pollutants, viz., 2-nitrophenol (ONP), 3-nitrophenol (MNP), 4-nitrophenol (PNP), 2,4-dinitrophenol (DNP), methyl orange (MO), congo red (CR), methylene blue (MB), and rhodamine B (RB) were carried out in the presence of NaBH 4 . The k app value of 0.1 mM 4NP was highest which was 1.8 × 10 −1 min −1 while the slowest rate was observed for CR and RB with k app 5.5 × 10 −3 and 5.4 × 10 −3 min −1 respectively. This article helps in the removal of toxic organic pollutants through green supported NPs.
P‐59: Advance System Solution for Driving Multi Array RGB LED Backlight (2008)

Abstract This paper presents an advanced and comprehensive system solution for driving multi‐array LED BL with advance features in a LCD TV and offers a cost effective algorithm for optimizing LED backlight power dissipation based on adaptive digital control of the power supplies, and compares the impact of LED dimming methods on color chromaticity accuracy. Experimental results and measurements are provided.
Efficient and versatile sensorless aberration correction for adaptive microscopy (2022)

We proposed a machine learning assisted adaptive optics method with high photon-efficiency and versatility. The method was used on a range of microscope modalities for fast aberration correction when imaging various samples with complex structures.
Multistack Switched-Capacitor Architecture with Coupled Magnetics for 48V-to-1V VRM (2022)

This paper presents the design and analysis of a family of multistack switched-capacitor architecture and coupled magnetics for 48 V-to-l V point-of-load voltage regulation mod-ules (VRMs). The architecture uses multiple stages of unregulated switched-capacitor cells to generate multiple layers of cascaded terminals with reduced voltage levels. The reduced voltage levels are loaded by switched-mode power converters controlled as current sources to perform voltage regulation and soft charging. Switches of the switched-capacitor cells and the current source cells are merged to reduce the component count and improve the performance. The magnetic components in the current source cells are coupled and combined. The effectiveness of the topology family is verified by simulation and experimental results.
ChemInform Abstract: Broensted Acid Catalyzed Alkylation of Indoles with Tertiary Propargylic Alcohols: Scope and Limitations. (2011)

Abstract Direct alkylation of a variety of indole derivatives with propargylic alcohols containing a quaternary carbon at the propargylic position (II) and (IV) is smoothly achieved in the presence of TosOH.
Cancer Cell Immortality: Targeting Telomerase (2017)

Overview Finding specific targeted agents for cancer therapy remains a challenge. One of the hallmarks of cancer is the limitless proliferation (immortalization) of cancer cells, which correlates with the activation of the ribonucleoprotein enzyme complex called telomerase. As 85–90% of primary human cancers express telomerase activity, while most normal cells do not, telomerase is a unique and almost universal therapeutic target for cancer. Although there have been several approaches developed for telomerase‐targeted therapies, there is still no agent that has been approved. This chapter focuses on the pros and cons of the different approaches to target telomerase and summarizes preclinical and clinical results. We will also review novel telomerase‐mediated telomere uncapping approaches that target telomerase‐expressing cancer cells, but not normal cells.
Data from Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Most human cancers converge to a deregulated methylome with reduced global levels and elevated methylation at select CpG islands. To investigate the emergence and dynamics of the cancer methylome, we characterized genome-wide DNA methylation in preneoplastic monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), including serial samples collected across disease course. We detected the aberrant tumor-associated methylation landscape at CLL diagnosis and found no significant differentially methylated regions in the high-count MBL-to-CLL transition. Patient methylomes showed remarkable stability with natural disease and posttherapy progression. Single CLL cells were consistently aberrantly methylated, indicating a homogeneous transition to the altered epigenetic state and a distinct expression profile together with MBL cells compared with normal B cells. Our longitudinal analysis reveals the cancer methylome to emerge early, which may provide a platform for subsequent genetically driven growth dynamics, and, together with its persistent presence, suggests a central role in disease onset.&lt;/p&gt;Significance:&lt;p&gt;DNA methylation data from a large cohort of patients with MBL and CLL show that epigenetic transformation emerges early and persists throughout disease stages with limited subsequent changes. Our results indicate an early role for this aberrant landscape in the normal-to-preneoplastic transition that may reflect a pan-cancer mechanism.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Rossi, p. 6&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 1&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Better-ear listening strategies for normal-hearing and hearing-impaired individuals (2008)

The current study was designed to examine how hearing-impaired (HI) listeners use better-ear listening. Better-ear performance was initially assessed for normal-hearing (NH) and HI participants using a connected-speech recognition test at two signal-to-noise-ratio (SNR) levels presented over insert earphones. Test conditions consisted of monaural, symmetric and asymmetric combinations of better and worse SNR conditions. SNRs were different for NH and HI groups. Stimuli were presented at each participant's most comfortable level; to account for audibility with HI participants, stimuli were spectrally shaped based on audiometric data. A second experiment investigated the role of spatial information using recordings of the same stimuli presented in a sound-dampened chamber at the same SNR differences, with the speech signal at 0° azimuth/elevation, and uncorrelated babble presented from eight speakers at the corners of the chamber. Listening strategies between NH and HI groups were similar across experiments; neither group consistently used an optimal listening strategy. Results will be discussed in terms of hearing-impaired pathologies, rehabilitation and amplification strategies.
Inhibition of the Induction of Cytolytic T Lymphocytes with Alloantisera Directed against H-2K and H-2D Gene Products (1978)

Alloantisera directed at gene products of the H-2Kd or H-2Dd loci on the stimulator cell were shown to inhibit specifically the generation of cytolytic T lymphocytes to those antigens. Thus, masking the antigens of one H-2 locus on the stimulator cell inhibits the induction of CTL to products of that locus but does not inhibit the induction of CTL to antigens of another H-2 locus. Alloantisera inhibition of the induction of cytolytic T lymphocytes occurred with both normal and primed responder cells and also occurred when the stimulating antigens were on whole cells or purified plasma membrane. Absorption on the appropriate spleen cells removed the inhibitory capacity of these alloantisera.
Effects of enzymatic hydrolysate from seahorse Hippocampus abdominalis on testosterone secretion from TM3 Leydig cells and in male mice (2016)

Protein hydrolysates, the so-called bioactive peptides, are specific protein fragments that have positive effects on several body functions and may improve human health. Marine organism-derived protein hydrolysates and bioactive peptides have shown to possess many physiological functions. Seahorses, used in traditional medicine, are generally ground to powder form either for direct application or for application following dissolution in warm water. In this present study, we purified, hydrolyzed, and characterized two bioactive peptides (ALC and PEP) obtained from seahorse (Hippocampus abdominalis). The hydrolysates derived from seahorse significantly upregulated the expression of cyclin D and cyclin E and increased cell proliferation and testosterone level in the TM3 mouse Leydig cell line. These findings suggest that the hydrolysates stimulate the proliferation of TM3 cells via the AKT, ERK, and JNK pathways. The decline in the circulating testosterone levels in older men is associated with various adverse health effects. Following daily intake of hydrolysates for 12 weeks, the circulating level of testosterone and the sperm count in mice were measured. We found increased sperm motility (sperm count) as well as an increase in the testosterone level in male mice following a 12-week intake of hydrolysates derived from H. abdominalis. Hence, it can be suggested that seahorse-derived hydrolysates play an important role in improving male health by improving the serum testosterone level.
Volatile phase profiling of mainstream smoke by glass capillary gas‐chromatographic techniques (1980)

Abstract A heated injection system for a microprocessor‐controlled GC has been developed for the (GC) 2 analysis of the volatile phase of whole smoke of a cigarette. Effects of injection port temperature and the presence of a Cambridge filter pad are demonstrated. Chromatograms are shown for smoke samples with and without a Cambridge Filter with the sample valve oven at 25°, 165° and 205°C. The use of a flame ionization and a nitrogen‐phosphorous detector is illustrated.
Diversity of hepatitis B virus X gene-related transcripts in hepatocellular carcinoma: a novel polyadenylation site on viral DNA (1991)

RNA was isolated from tissue of two patients with hepatocellular carcinoma developed on the background of a chronic hepatitis B virus infection. For identification and characterization of 3' ends of X gene open reading frame (ORF)-related transcripts, RNA was reverse transcribed into cDNA and subjected to polymerase chain reaction. Cloned amplification products from tumor tissue of one patient represented an approximately even distribution of transcripts terminating at the established poly(A) signal (standard transcripts) and of truncated transcripts terminating at a CATAAA poly(A) signal within the 3' end region of X gene ORF (truncated transcripts). Amplified cDNA from tumor tissue of the second patient could be attributed mainly to the standard type of transcripts, whereas cDNA from the nontumor tissue of the same patient could be assigned to four groups of transcripts: (i) standard transcripts, (ii) transcripts with internal deletions affecting the 3' end of the X gene, (iii) truncated transcripts, and (iv) hybrid transcripts displaying 5' sequences from the X gene ORF fused to cellular sequences.
Data from CD44<sup>+</sup> Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell–Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1 (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Human tumors consist of heterogeneous populations of cells with distinct marker expression and functional properties. In squamous cell carcinoma of the head and neck (SCCHN), CD44 is a well-characterized marker of a resilient subpopulation of cells associated with increased tumorigenesis, radioresistance, and chemoresistance. Evidence indicates that these cells have an immunosuppressive phenotype; however, mechanisms have been elusive.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Using primary human SCCHN tumor samples and patient-derived xenografts, we examined the phenotypes of subsets of tumor cells and investigated mechanisms regulating their immunogenicity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CD44&lt;sup&gt;+&lt;/sup&gt; cells in primary human SCCHN were found to have an epithelial-to-mesenchymal (EMT) phenotype and were less immunogenic than CD44&lt;sup&gt;−&lt;/sup&gt; cells when cultured with autologous CD8&lt;sup&gt;+&lt;/sup&gt; tumor-infiltrating T cells. Selective expression of the programmed death-ligand 1 (PD-L1) was observed on CD44&lt;sup&gt;+&lt;/sup&gt; cells compared with CD44&lt;sup&gt;−&lt;/sup&gt; cells and was associated with constitutive phosphorylation of STAT3 on CD44&lt;sup&gt;+&lt;/sup&gt; cells. Importantly, inhibition of STAT3 decreased expression of PD-L1 on CD44&lt;sup&gt;+&lt;/sup&gt; cells. IFNγ treatment preferentially induced even further PD-L1 expression on CD44&lt;sup&gt;+&lt;/sup&gt; cells and was associated with enhanced IFNγ receptor expression and phosphorylation of STAT1. Finally, the decreased immunogenicity of CD44&lt;sup&gt;+&lt;/sup&gt; cells was partially reversed by antibody blockade of the programmed death 1 (PD-1) receptor, indicating that the differences in PD-L1 expression between CD44&lt;sup&gt;+&lt;/sup&gt; and CD44&lt;sup&gt;−&lt;/sup&gt; cells are biologically and clinically relevant.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings provide a mechanism by which long-lived CD44&lt;sup&gt;+&lt;/sup&gt; tumor-initiating cells can selectively evade host immune responses and provide rationale for targeting the PD-1 pathway in the adjuvant therapy setting of SCCHN. &lt;i&gt;Clin Cancer Res; 22(14); 3571–81. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Use of Antiepileptic Drugs and Risk of Psychiatric Diseases in People with Epilepsy: A Retrospective Case-Control Study (P4.218) (2016)

OBJECTIVE:To investigate the relationship between usage of antiepileptic drugs (AEDs) and development of psychiatric diseases in people with epilepsy (PWE) BACKGROUND: PWE have relatively higher risk of developing psychiatric illnesses. However, there is a lack of studies investigating AED usage and subsequent development of psychiatric comorbidities in PWE. METHODS: A retrospective case-control study of 747 PWE (91 cases, 656 controls) was conducted. Cases were defined as epileptic patients with subsequent diagnosis of psychiatric illnesses; controls were defined as epilepsy patients without psychiatric comorbidities. Both groups were matched for age, gender, seizure and epilepsy types. Any AED use for longer than 6 months was recorded. AED usages between the diagnoses of epilepsy and psychiatric disease in the index group were compared to the usages after the diagnosis of epilepsy in the control group. RESULTS: Among the 747 PWE, valproate was the most commonly prescribed AED (47.7[percnt]), followed by carbamazepine (28.5[percnt]), phenytoin (27.4[percnt]), clobazam (16.7[percnt]), lamotrigine (15.4[percnt]), levetiracetam (11.9[percnt]), phenobarbitone (11.5[percnt]), oxcarbazepine (9.9[percnt]), topiramate (6.2[percnt]) and gabapentin (5.1[percnt]). Multivariate logistic regression analysis adjusted for concurrent use of other AED drugs showed that the increased risk of developing psychiatric comorbidities was associated with topiramate (odds ratio(OR) 2.65, 95[percnt]CI [1.157,6.05]), while decreased risks of developing psychiatric comorbidities were associated with valproate (OR 0.48, 95[percnt]CI [0.30 - 0.79]), carbamazepine (OR 0.52, 95[percnt]CI [0.29,0.94]), lamotrigine (OR 0.27, 95[percnt]CI [0.10-0.69]), levetiracetam (OR 0.188, 95[percnt]CI [0.06 - 0.65]). CONCLUSIONS:Use of topiramate may be associated with increased risk of developing psychiatric comorbidities in PWE, while the use of valproate, carbamazepine, lamotrigine, levetiracetam may be associated with lower risk. Further research is required to clarify the causal relationship between AEDs and the psychiatric comorbidities in epilepsy.
Genetically engineered tri-band microstrip antenna with improved directivity for mm-wave wireless application (2022)

&lt;abstract&gt;&lt;p&gt;Multi-band microstrip patch antennas are convenient for mm-wave wireless applications due to their low profile, less weight, and planar structure. This paper investigates patch geometry optimization of a single microstrip antenna by employing a binary coded genetic algorithm to attain triple band frequency operation for wireless network application. The algorithm iteratively creates new models of patch surface, evaluates the fitness function of each individual ranking them and generates the next set of offsprings. Finally, the fittest individual antenna model is returned. Genetically engineered antenna was simulated in ANSYS HFSS software and compared with the non-optimized reference antenna with the same dimensions. The optimized antenna operates at three frequency bands centered at 28 GHz, 40 GHz, and 47 GHz whereas the reference antenna operates only at 28 GHz with a directivity of 6.8 dB. Further, the test result exhibits broadside radiation patterns with peak directivities of 7.7 dB, 12.1 dB, and 8.2 dB respectively. The covered impedance bandwidths when S&lt;sub&gt;11&lt;/sub&gt;$ \leq $-10 dB are 1.8 %, 5.5 % and 0.85 % respectively.&lt;/p&gt;&lt;/abstract&gt;
Determination of cyclic delay for CDD utilizing RMS delay spread in OFDMA multiuser scheduling systems (2010)

The multiuser diversity gain increases with the degree and dynamic range of channel fluctuations. For a multi-antenna orthogonal frequency division multiplexing (OFDM) system operating in a channel with limited fluctuations, cyclic delay diversity (CDD) was proposed to increase frequency selectivity. This is achieved by introducing a cyclic delay between the different transmit antennas thereby increasing the effective number of paths in the resulting channel. In this paper, for a multiuser system, we propose a scheme to determine peruser optimal cyclic delay value based on the knowledge of the root-mean-square (RMS) delay spread of the channel. We show that the proposed technique achieves better performance than a conventional fixed cyclic delay scheme and that the throughput is very close to the optimal sum rate possible with CDD.
Molybdenum and Tungsten Complexes That Contain the Diamidoamine Ligands [(C6F5NCH2CH2)2NMe]2-, [(3,4,5-C6H2F3NCH2CH2)2NMe]2-, and [(3-CF3C6H4NCH2CH2)2NMe]2- (2004)

Molybdenum and tungsten complexes have been prepared that contain three different types of diamidoamine ligands of the type [(ArNCH2CH2)2NMe]2- ([ArNMe]2-, where Ar = C6F5, 3,4,5-F3C6H2, 3-CF3C6H4). The starting materials, which are of the type [Et3NH]{[ArNMe]MCl3}, are prepared from MCl4 reagents and the ligand upon addition of triethylamine. X-ray studies for [Et3NH]{[C6F5NMe]MoCl3}, [Et3NH]{[C6F5NMe]WCl3}, and [Bu4N]{[3-CF3C6H4NMe]MoCl3} reveal that the amido nitrogens are approximately cis to one another in a distorted-pseudooctahedral environment. Addition of various alkylating reagents to various [Et3NH]{[ArNMe]MCl3} species led to the formation of [C6F5NMe]MoMe2 (3), [C6F5NMe]Mo(CH2CMe3)Cl (4b), [C6F5NMe]W(CH2CMe3)Cl (5), [3,4,5-F3C6H2NMe]Mo(CH2CMe3)Cl (8), [3,4,5-F3C6H2NMe]Mo(CH2CMe3)(CCMe3) (9), [3,4,5-F3C6H2NMe]Mo(CH2SiMe3)2 (10), [3,4,5-F3C6H2NMe]W(CH2CMe3)(CCMe3) (11a), [3,4,5-F3C6H2NMe]W(CH2SiMe3)(CSiMe3) (11b), [3-CF3C6H4NMe]Mo(CH2SiMe3)2 (13), [3-CF3C6H4NMe]Mo(CH2CMe3)Cl (14), and [3-CF3C6H4NMe]Mo(CCMe3)(CH2CMe3) (15). All M4+ complexes are paramagnetic with magnetic moments that are expected for high-spin d2 complexes. X-ray studies of 3, 4b, and 9 show them to be trigonal-bipyramidal species in which the amido nitrogens occupy equatorial positions. The alkylidyne complexes form via elimination of dihydrogen, an “α,α-dehydrogenation” reaction, as shown by measuring the dihydrogen evolved in one case.
Homojunction diode of CuInSe2 thin film fabricated by nitrogen implantation (1993)

Rectifying homojunction have been fabricated in polycrystalline CuInSe2 thin film. The p-n junction diode was obtained by short annealing in nitrogen atmosphere at 450 °C following the ion implantation of nitrogen with the energy and the dose of 50 keV and 1×1015 cm−2, respectively. The properties of the near surface region in the films implanted have been studied by the Raman scattering spectroscopy. The secondary ion mass spectroscopy depth profile of the nitrogens in the CuInSe2 film and the capacitive-voltage characteristics of the rectifying diode have been measured to characterize the junction properties. The photovoltaic characteristics in AM 1.0, 100 mW/cm2 are shown with the efficiency of 0.35%.
An Enzyme Assembly Line (2008)

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Mononuclear leukocyte apoptosis in haemodialysis patients: the role of cell thiols and vitamin E (2003)

This study showed an association between an increased apoptotic rate and decreased SHi in PBML of HD patients, but not of CAPD patients. These changes are partially due to different pro-apoptogens that accumulate in the plasma and are at least partially prevented by exogenous antioxidants able to restore SHi, such as vitamin E or thiol suppliers.