gebhart/patrepeval huggingface dataset:
Feasibility of a Smartphone-Based Hearing Aid App for Mild-to-Moderate Hearing Loss: Prospective Multicenter Randomized Controlled Trial (2023)

The HA showed better performance than the SHAA in word recognition and the HINT. However, the SHAA was significantly better than unaided hearing in terms of amplification. The SHAA may be a useful hearing assistance device for patients with mild-to-moderate hearing loss when listening to soft sounds in quiet conditions. The SHAA demonstrated poorer performance than the HA in the mid- to high-frequency sounds that are important for word recognition, sound quality, and hearing in noisy conditions. Further development of the signal technology of SHAAs is needed to improve the sound quality of mid- to high-frequency sounds and overcome noisy environments.
Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial (2018)

The objective of this study was to determine the ability of either aerobic or resistance training to counter weight-loss-associated bone loss in older adults. There were 187 older adults (67 years, 70% women, 64% white) with obesity (BMI = 34.5 ± 3.7 kg/m<sup>2</sup> ) and cardiovascular disease and/or metabolic syndrome who were randomized to participate in an 18-month, community-based trial, with a follow-up assessment at 30 months. Intervention arms included: weight loss alone (WL; 7% to 10% baseline weight), WL plus aerobic training (WL + AT), and WL plus resistance training (WL + RT), as well as DXA-acquired total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD), and trabecular bone score (TBS). Biomarkers of bone turnover (procollagen type 1 N-terminal propeptide, C-terminal telopeptide of type 1 collagen) were measured at baseline, 6, 18, and 30 (aBMD and TBS only) months. CT-acquired hip and spine volumetric BMD (vBMD), cortical thickness, and bone strength were measured in a subset at baseline (n = 55) and 18 months. Total hip aBMD was reduced by 2% in all groups at 18 months, with a primary analysis showing no significant treatment effects for any DXA, biomarker, or CT outcome. After adjustment for WL and follow-up at 30 months, secondary analyses revealed that total hip [-0.018 (-0.023 to -0.012) g/cm<sup>2</sup> versus -0.025 (-0.031 to -0.019) g/cm<sup>2</sup> ; p = 0.05] and femoral neck [-0.01 (-0.009 to 0.008) g/cm<sup>2</sup> versus -0.011 (-0.020 to -0.002) g/cm<sup>2</sup> ; p = 0.06] aBMD estimates were modestly attenuated in the WL + RT group compared with the WL group. Additionally, lumbar spine aBMD was increased in the WL [0.015 (0.007 to 0.024) g/cm<sup>2</sup> ] and the WL + RT [0.009 (0.000 to 0.017) g/cm<sup>2</sup> ] groups compared with the WL + AT [-0.003 (-0.012 to 0.005)g/cm<sup>2</sup> ] group; both p ≤ 0.01. Community-based exercise does not prevent bone loss during active WL in older adults; however, adding RT may help minimize long-term hip bone loss. © 2018 American Society for Bone and Mineral Research.
A Compact Model Satisfying Gummel Symmetry in Higher Order Derivatives and Applicable to Asymmetric MOSFETs (2008)

This paper presents a new concept for the MOSFET saturation voltages at the drain and source sides referenced to bulk, and applies them to the popularly used smoothing functions for the effective drain-source voltage ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V<sub>ds,eff</sub> </i> ). The proposed model not only builds in physically all the terminal-bias variations, but is also extended to include source/drain asymmetry in real devices in a single-core compact model. The new model resolves a key bottleneck in existing models for passing the Gummel symmetry test (GST) in higher order derivatives, which has to be traded off for the geometry-dependent <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V<sub>ds,eff</sub> </i> smoothing parameter. The complete drain-current model, including the effects of velocity saturation and overshoot as well as source/drain series resistance, has also been reformulated with the same ldquobulk-referencingrdquo concept. It is shown that the proposed model passes the GST in all higher order derivatives without any constraint on the value of the smoothing parameter. It also demonstrates potential extension to modeling asymmetric MOSFETs, which is becoming an important model capability.
Syntheses of lignans from 2,3-diarolybutanes (1978)

2,3-Diarolybutanes can be selectively converted with high stereospecificity into 2,5-diaryl-3,4-dimethylfurans or 2,3-diarylbutanes. The racemic forms of the dibenzylbutane ligans, dihydroguaiaretic acid dimethyl ether (2), austrobilignan-5 (12), and austrobilignan-6 (14) and the diaryltetrahydrofuran lignans, veraguensin (3) and its piperonyl analogue (10) have been readily synthesized. A short convenient synthesis of the aryltetralin lignan, galbulin (5) and the all-trans-tetrahydrofuran lignan, galbelgin (6) are also reported.
On-chip microwave photonic sensor featuring silicon-polymer hybrid subwavelength grating waveguide and bowtie antenna (Conference Presentation) (2018)

A photonic microwave sensor based on electro-optic (EO) polymer infiltrated silicon subwavelength grating (SWG) waveguide and bowtie antenna is designed and experimentally demonstrated. The microwave sensor receives wireless microwave signals via the bowtie antenna. The electrical field between the extension bars of the bowtie antenna modulates the light guided in the SWG based Mach–Zehnder interferometer (MZI). Thus, microwave signals can be detected by measuring the intensity variation of light from the MZI output. The EO polymer infiltrated SWG does not require ion implantation and has low optical propagation loss. Furthermore, compared to slotted silicon waveguides, the EO polymer poling efficiency on SWG structure can be greatly increased due to wider poling separations and thus the increased breakdown voltage. In order to achieve strong microwave field enhancement, the impedance of the bowtie antennas is tailored. The optimized bowtie antennas operate at 15 GHz and provide >1000X field enhancement while only occupy an area of 7.6 mm X 0.3 mm. Leveraging the folded SWG waveguide, high EO coefficient polymer, and large field enhancement from bowtie antenna, an ultra-sensitive and compact microwave photonic sensor has been demonstrated.
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation (2022)

Anemia of inflammation, also known as anemia of chronic disease, is refractory to erythropoietin (EPO) treatment, but the mechanisms underlying the EPO refractory state are unclear. Here, we demonstrate that high mobility group box-1 protein (HMGB1), a damage-associated molecular pattern molecule recently implicated in anemia development during sepsis, leads to reduced expansion and increased death of EPO-sensitive erythroid precursors in human models of erythropoiesis. HMGB1 significantly attenuates EPO-mediated phosphorylation of the Janus kinase 2/STAT5 and mTOR signaling pathways. Genetic ablation of receptor for advanced glycation end products, the only known HMGB1 receptor expressed by erythroid precursors, does not rescue the deleterious effects of HMGB1 on EPO signaling, either in human or murine precursors. Furthermore, surface plasmon resonance studies highlight the ability of HMGB1 to interfere with the binding between EPO and the EPOR. Administration of a monoclonal anti-HMGB1 antibody after sepsis onset in mice partially restores EPO signaling in vivo. Thus, HMGB1-mediated restriction of EPO signaling contributes to the chronic phase of anemia of inflammation.
High-Frequency Electromagnetic Induction Sensing of Nonmetallic Materials (2017)

We introduce a frequency-domain electromagnetic induction (EMI) instrument for detection and classification of objects with either high ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sigma &gt; 10^{5}~\textrm {S/m}$ </tex-math></inline-formula> ) or intermediate ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1 &lt; \sigma &lt; 10^{5}~\textrm {S/m}$ </tex-math></inline-formula> ) electrical conductivity. While high conductivity metallic targets exhibit a quadrature peak response for frequencies in a traditional EMI regime under 100 kHz, the response of intermediate conductivity objects manifests at higher frequencies, between 100 kHz and 15 MHz. Materials such as carbon fiber or conducting salt solutions exhibit conductivities in this intermediate range and are undetectable by traditional low-frequency EMI instruments. To detect these intermediate conductivity targets, we developed a high-frequency EMI (HFEMI) instrument with a frequency range extended to 15 MHz. The HFEMI instrument requires novel hardware considerations, coil design, and data processing schemes. Most importantly, the wire lengths of transmit and receive coils are shorter than those of traditional frequency EMI sensors, so that the phase on the transmit and receive coils is nearly constant. We present the hardware and software aspects of the HFEMI instrument along with preliminary data, demonstrating its ability to detect intermediate conductive objects.
Synthesis of some substituted 5H-dibenz[b,f]azepines as potential antimalarials (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of some substituted 5H-dibenz[b,f]azepines as potential antimalarialsRajendra S. Varma, L. K. Whisenant, and David W. Boykin Jr.Cite this: J. Med. Chem. 1969, 12, 5, 913–914Publication Date (Print):September 1, 1969Publication History Published online1 May 2002Published inissue 1 September 1969https://pubs.acs.org/doi/10.1021/jm00305a048https://doi.org/10.1021/jm00305a048research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Utilizing Computational Fluid Dynamics (CFD) Analysis as a Design Tool in Frac-Packing Applications To Improve Erosion Life (2006)

Abstract Frac packing tool erosion is becoming a growing concern as more high-profile deepwater wells are completed using this technique. Today many deepwater wells require frac pack pump rates of at least 40 barrels per minute (bbl/min) with proppant loads reaching 300,000 lbs. As zone lengths are increased and multi-zone operations are performed jobs requiring 60 bbl/min pump rates with proppant loads reaching 900,000 lbs. may be more typical. The current frac packing tool designs must be optimized to accommodate the higher pump rates and proppant volumes required to complete these deepwater wells. Computational fluid dynamics (CFD) analysis of these systems provides valuable insight to what is physically happening to the tools at these high pump rates and proppant loads. Analyzing various patterns, such as velocity, fluid path, erosion, and sand concentration at high rates helps identify critical areas within the system that require design optimization. CFD analysis is a cost effective alternative to trial-and-error testing, which can cost upwards of $150,000 per test and prolong the development phase. Two sizes of systems have been analyzed using CFD analysis and modified based on the results of that analysis. Full scale tests were also performed at 40 bbl/min on these two systems to compare the actual results with that of the CFD analysis. The CFD analysis was able to generate accurate profiles of the physical erosion patterns observed after the full scale tests were completed. Although CFD cannot accurately predict magnitudes for erosion rates, it can predict erosion profiles and velocity magnitudes. Research is currently ongoing to accurately predict erosion rate magnitudes. This paper will detail the development, analysis and qualification testing of a next-generation frac packing system capable of use in ultra-high-rate operations.
Tethered capsule OCT endomicroscopy: from bench to bedside at the primary care office (Conference Presentation) (2016)

We have developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires microscopic images of the entire esophagus in unsedated subjects in a quick and comfortable procedure. To test its capabilities of TCE to become a population-based screening device, we conducted a clinical feasibility study in the primary care office. The swept-source OCT imaging system (1310nm central wavelength, 40kHz A-line rate, 10um axial resolution) together with the tethered capsule catheter (11x25mm capsule attached to a flexible tether) were transferred to the PCP office where unsedated patients scheduled for non-urgent PCP visits swallowed the capsule and microscopic OCT images of the entire esophagus were collected. After the whole length of the esophagus was imaged, the catheter was disinfected for reuse. Twenty subjects were enrolled in the study, including nine female and eleven male. All TCE procedures were performed by a nurse and lasted in average 5:42 ± 1:54 min. High-resolution images of the esophagus were obtained in all seventeen subjects that swallowed the capsule. Our clinical experience in this cohort, subject feedback, image quality, and technological adaptations for efficient utilization in this setting will be presented. The ease and simplicity of the procedure combined with high quality of the images demonstrate the potential for this technology to become a population-based screening device. Technology limitations and future development guided by findings from this initial experience will be discussed with the goal of effectively translating TCE to the outpatient primary care setting.
Construction and application of the recombinant influenza viruses (2009)

インフルエンザウイルスのリバースジェネティクスの確立により，ウイルス蛋白質を任意に改変した変異ウイルスの作製が可能になった．そういった変異ウイルスは，現在のインフルエンザの基礎研究において欠かすことのできない有用なツールとして活用されている．また，応用面においても，現在備蓄が進んでいるH5N1プレパンデミックワクチンには本法を用いて作製された弱毒変異ウイルスが用いられている．今後，変異ウイルス作製技術は，インフルエンザの次世代ワクチンの開発にも大いに貢献することが期待される．一方，リバースジェネティクスを用いた外来性エピトープや外来性遺伝子を発現する組換えインフルエンザウイルスの構築により，効果的な免疫応答を惹起する多価ワクチンや遺伝子治療用デリバリーベクターへの応用が考えられている．現時点では，組換えウイルスの安定性，発現性，増殖性などの問題点を改善する必要性が指摘されているものの，インフルエンザウイルスベクターの持つ数多くの利点を活かすべく実用化を目指したさまざまなアプローチが展開されている．
Meso-Unsubstituted Iron Corrole in Hemoproteins: Remarkable Differences in Effects on Peroxidase Activities between Myoglobin and Horseradish Peroxidase (2009)

Myoglobin (Mb) and horseradish peroxidase (HRP) were both reconstituted with a meso-unsubstituted iron corrole and their electronic configurations and peroxidase activities were investigated. The appearance of the 540 nm band upon incorporation of the iron corrole into apoMb indicates axial coordination by the proximal histidine imidazole in the Mb heme pocket. Based on (1)H NMR measurements using the Evans method, the total magnetic susceptibility of the iron corrole reconstituted Mb was evaluated to be S = 3/2. In contrast, although a band does not appear in the vicinity of 540 nm during reconstitution of the iron corrole into the matrix of HRP, a spectrum similar to that of the iron corrole reconstituted Mb is observed upon the addition of dithionite. This observation suggests that the oxidation state of the corrole iron in the reconstituted HRP can be assigned as +4. The catalytic activities of both proteins toward guaiacol oxidation are quite different; the iron corrole reconstituted HRP decelerates H(2)O(2)-dependent oxidation of guaiacol, while the same reaction catalyzed by iron corrole reconstituted Mb has the opposite effect and accelerates the reaction. This finding can be attributed to the difference in the oxidation states of the corrole iron when these proteins are in the resting state.
Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen‐independent progression in the human prostate LNCaP tumor model (1998)

Progression to androgen independence remains the main obstacle to improving survival and quality of life in patients with advanced prostate cancer. Induction of differentiation may serve as a rational basis for prevention of progression to androgen independence by modulating gene expression activated by castration or upregulated during androgen-independent progression. The objectives of this study were to characterize the in vitro effects of sodium butyrate on human prostate cancer cell growth, PSA gene expression, and differentiation in the LNCaP tumor model and to determine whether tumor progression in vivo is delayed by isobutyramide, an orally bioavailable butyrate analogue with a longer half-life. The effects of isobutyramide on LNCaP tumor growth and serum PSA levels in both intact and castrate male mice were compared to controls. At concentrations > 1 mM, butyrate induced dose-dependent changes towards a more differentiated phenotype, G1 cell cycle arrest, and an 80% decrease in LNCaP cell growth rates. PSA gene expression was increased threefold by butyrate, indicative of differentiation-enhanced gene expression. The half-life of isobutyramide in athymic mice was determined by gas chromatography to be 4 h. During a 4 week period in intact-placebo mice, tumor volume and serum PSA increased 4.1- and 6.6-fold, respectively, compared to twofold and 2.7-fold increases in tumor volume and serum PSA in intact-treated mice. During a 7 week period in castrate-placebo mice, tumor volume and serum PSA levels increased 2.4-fold and fourfold, respectively, compared to a 50% reduction in tumor volume and a twofold increase in serum PSA above nadir levels in castrate mice treated with adjuvant isobutyramide. Isobutyramide treatment induced pronouced morphological changes in LNCaP tumor cells, with loss of defined nucleoli and dispersion of chromatin distribution. LNCaP tumor PSA mRNA levels actually increased threefold, indicative of differentiation-enhanced gene expression. This study demonstrates that butyrate causes LNCaP cell cycle arrest and increased PSA gene expression, both indicative of differentiation. The combination of castration and adjuvant isobutyramide was synergistic in delaying tumor progression. Decreased tumor cell proliferation and increased PSA gene expression induced by isobutyramide results in disconcordant changes in serum PSA and tumor volume and reduces the utility of serum PSA as a marker of response to therapy. J. Cell. Biochem. 69:271–281, 1998. © 1998 Wiley-Liss, Inc.
Development of a Food-Grade Integration Vector for Heterologous Gene Expression and Protein Secretion in Lactococcus lactis (2006)

A food-grade integration vector based on site-specific recombination was constructed. The 5.7-kb vector, pIMA20, contained an integrase gene and a phage attachment site originating from bacteriophage A2, with the α-galactosidase gene from Lactobacillus plantarum KCTC 3104 as a selection marker. pIMA20 was also equipped with a controllable promoter of nisA (P niA ) and a signal peptide-encoding sequence of usp45 (SP usp45 ) for the production and secretion of foreign proteins. pIMA20 and its derivatives mediated site-specific integration into the attB-like site on the Lactococcus lactis NZ9800 chromosome. The vector-integrated recombinant lactococci were easily detected by the appearance of blue colonies on a medium containing X-α-gal and also by their ability to grow on a medium containing melibiose as the sole carbon source. Recombinant lactococci maintained these traits in the absence of selection pressure during 100 generations. The α-amylase gene from Bacillus licheniformis, lacking a signal peptide-encoding sequence, was inserted downstream of P nisA and SP usp45 in pIMA20, and the plasmid was integrated into the L. lactis chromosome. α-Amylase was successfully produced and secreted by the recombinant L. lactis, controlled by the addition and concentration of nisin.
Light-Microscopic Stereologic Analysis of Spontaneous and Steroid-Induced Canine Prostatic Hyperplasia (1987)

A combined light-microscopic and stereologic analysis of the canine prostate was performed under the following experimental conditions: intact and castrated dogs, spontaneous benign prostatic hyperplasia, intact and castrated dogs after treatment with testosterone, 5 alpha-dihydrotestosterone or 3 alpha-androstanediol in combination with estradiol. Regarding the absolute amounts of the glandular and stromal parts of the prostate as well as the glandular cells, no difference was found among the testosterone, 3 alpha-androstanediol and 5 alpha-dihydrotestosterone treated castrated dogs. Treatment with 5 alpha-dihydrotestosterone or 3 alpha-androstanediol in combination with 17 beta-estradiol induced a four-fold increase in glandular and a two-fold increase in stromal tissue. The glandular to stromal tissue ratio equals that found in spontaneous canine hyperplasia, which is indicative of the glandular type of spontaneous canine hyperplasia. Therefore, it can be stated that treatment with 5 alpha-dihydrotestosterone or 3 alpha-androstanediol combined with 17 beta-estradiol not only induces prostatic overgrowth but also leads to prostatic hyperplasia of the glandular type. However, the stereologic analysis of canine prostates following steroid administration shows that canine hyperplasia is primarily a glandular disease, while human benign prostatic hyperplasia shows more stromal activation.
FluidNet: A Flexible Cloud-Based Radio Access Network for Small Cells (2015)

Cloud-based radio access networks (C-RAN) have been proposed as a cost-efficient way of deploying small cells. Unlike conventional RANs, a C-RAN decouples the baseband processing unit (BBU) from the remote radio head (RRH), allowing for centralized operation of BBUs and scalable deployment of light-weight RRHs as small cells. In this work, we argue that the intelligent configuration of the front-haul network between the BBUs and RRHs, is essential in delivering the performance and energy benefits to the RAN and the BBU pool, respectively. We propose FluidNet-a scalable, light-weight framework for realizing the full potential of C-RAN. FluidNet deploys a logically re-configurable front-haul to apply appropriate transmission strategies in different parts of the network and hence cater effectively to both heterogeneous user profiles and dynamic traffic load patterns. FluidNet's algorithms determine configurations that maximize the traffic demand satisfied on the RAN, while simultaneously optimizing the compute resource usage in the BBU pool. We prototype FluidNet on a 6 BBU, 6 RRH WiMAX C-RAN testbed. Prototype evaluations and large-scale simulations reveal that FluidNet's ability to re-configure its front-haul and tailor transmission strategies provides a 50% improvement in satisfying traffic demands, while reducing the compute resource usage in the BBU pool by 50% compared to baseline schemes.