gebhart/patrepeval huggingface dataset:
Third Harmonic Exploitation in Passive UHF RFID (2015)

This paper unfolds the recent concept of using harmonic signals generated by the nonlinear behavior of traditional passive UHF RF identification (RFID) chips. The harmonics generation of passive RFID chips is analyzed to highlight the influences of the matching network and the tag antenna. The proposed study relies on a theoretical model that explains the role in the harmonic production of different elements constituting the tag. The model also shows how to achieve a second communication channel exploiting the third harmonic frequency in addition to the fundamental frequency channel. Specifications and methodology are explained in a harmonic communication scenario. The regulations, harmonic RFID reader considerations, harmonic tag guidelines design, and metrics for its evaluation are discussed. In compliance with the standard regulations EPC Class-1 Gen2 RFID, a design example is presented. The performance of the solution is illustrated from simulation and measurements. The prototype example operates simultaneously at fundamental and third harmonic frequencies with a read range greater than 4.5 m.
SYNTHESIS AND RADICAL POLYMERIZATION OF BIFUNCTIONAL MALEIMIDES WITH DIFFERENT FUNCTIONAL REACTIVITIES (2000)

Three bifunctional N-phenylmaleimide derivatives, N-[4-(2-hydroxy-3-methacryloyloxy propyloxycarbonyl)phenyl]male-imide (GMAPMI, 1), N-(4-methacryloyloxyphenyl) maleimide (MAPMI, 2) and 4-(4-maleimidobenzoyloxy)styrene (MIBOSt, 3) having radically polymerizable maleimide and vinyl groups together have been synthesized and polymerized. Polymerizations of the bifunctional maleimide monomers were carried out using a radical initiator at 55°C and the results were compared with those obtained by self-polymerization in the absence of ini-tors. All of the polymers obtained were insoluble in organic solvents owing to cross-linking between different functional groups. The reactivity for homopolymerization of monomer 3 is higher than that of monomers 1 and 2 because the styryl moiety of monomer 3 has better electron-donor strength than the methacrylate moiety. Under the same conditions, GMAPMI was copolymerized with N-vinyl-2-pyrrolidone and styrene as an electron-donor to give higher conversions by electron-donor/acceptor polymerization in which the maleimide moiety of GMAPMI mainly involved as an electron acceptor.
Near‐Infrared and Short‐Wavelength Infrared Photodiodes Based on Dye–Perovskite Composites (2017)

Organohalide perovskites have emerged as promising light‐sensing materials because of their superior optoelectronic properties and low‐cost processing methods. Recently, perovskite‐based photodetectors have successfully been demonstrated as both broadband and narrowband varieties. However, the photodetection bandwidth in perovskite‐based photodetectors has so far been limited to the near‐infrared regime owing to the relatively wide band gap of hybrid organohalide perovskites. In particular, short‐wavelength infrared photodiodes operating beyond 1 µm have not yet been realized with organohalide perovskites. In this study, narrow band gap organic dyes are combined with hybrid perovskites to form composite films as active photoresponsive layers. Tuning the dye loading allows for optimization of the spectral response characteristics and excellent charge‐carrier mobilities near 11 cm 2 V −1 s −1 , suggesting that these composites combine the light‐absorbing properties or IR dyes with the outstanding charge‐extraction characteristics of the perovskite. This study demonstrates the first perovskite photodiodes with deep near‐infrared and short‐wavelength infrared response that extends as far as 1.6 µm. All devices are solution‐processed and exhibit relatively high responsivity, low dark current, and fast response at room temperature, making this approach highly attractive for next‐generation light‐detection techniques.
Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps (2017)

Correction to:Clinical and Translational Gastroenterology (2016) 7, e188; doi:10.1038/ctg.2016.48. Published online 1 September 2016 In the Conflict of interest section, the Financial support section should read: This work was supported by the National Cancer Institute at the National Institutes of Health (Grant numbers R01 CA170357 and CA204013). In addition, funding was generously provided by a grant from Eugene and Eva Lane through the Mayo Foundation.
Closed-form approximate analysis of the fundamental and higher-order modes in rectangular-channel and planar-slab dielectric waveguides (1993)

In previous work, we have addressed the problem of describing the fundamental guided mode in a dielectric waveguiding structure using variational principles. Using this method, the value of the propagation constant and a Gaussian wavefield approximation for the fundamental mode are determined using variational arguments based on the scalar wave equation. In this paper, we present the extension of this method to include higher order modes. In this extension, the higher order modes are approximated by Hermite Gaussian functions. We will present results of the higher order analysis, along with the sets of equations used to describe the higher order modes. The structures of interest are planar slab dielectric waveguides and rectangular channel dielectric waveguides. The variational method is computationally fast, and good agreement is seen with other methods of analysis. Ways to increase accuracy will also be briefly discussed.
Nanopillared Chitosan/Gelatin Films: A Biomimetic Approach for Improved Osteogenesis (2019)

Biomimicry strategies, inspired from natural organization of living organisms, are being widely used in the design of nanobiomaterials. Particularly, nonlithographic techniques have shown immense potential in the facile fabrication of nanostructured surfaces at large-scale production. Orthopedic biomaterials or coatings possessing extracellular matrix-like nanoscale features induce desirable interactions between the bone tissue and implant surface, also known as osseointegration. In this study, nanopillared chitosan/gelatin (C/G) films were fabricated using nanoporous anodic alumina molds, and their antibacterial properties as well as osteogenesis potential were analyzed by comparing to the flat C/G films and tissue culture polystyrene as controls. In vitro analysis of the expression of RUNX2, osteopontion, and osteocalcin genes for mesenchymal stem cells as well as osteoblast-like Saos-2 cells was found to be increased for the cells grown on nano C/G films, indicating early-stage osteogenic differentiation. Moreover, the mineralization tests (quantitative calcium analysis and alizarin red staining) showed that nanotopography significantly enhanced the mineralization capacity of both cell lines. This work may provide a new perspective of biomimetic surface topography fabrication for orthopedic implant coatings with superior osteogenic differentiation capacity and fast bone regeneration potential.
Cover Picture: An Improved Perylene Sensitizer for Solar Cell Applications (ChemSusChem 7/2008) (2008)

The cover picture shows the working principle of a dye-sensitized solar cell based on a novel perylene organic sensitizer (dye), which exhibits two absorption bands at 620 and 462 nm and reversible oxidation and reduction potentials. The energetic alignment of the HOMO and LUMO of the dye is well suited for electron injection into the TiO2 conduction band as well as for regeneration of the dye by either an electrolyte containing a redox system or a solid-state hole conductor. In their Communication on page 615 ff., M. K. Nazeeruddin et al. report that a solar cell comprised of perylene-anchored TiO2 films and the iodine–iodide redox couple yields an unprecedented incident monochromatic photon-to-current conversion efficiency of 87%. The thiophenol donor groups provide directionality in the excited state leading to an improved short-circuit current density, open-circuit potential, and power conversion efficiency under standard AM 1.5 solar conditions.
Icosahedral AlCuFe quasicrystal at high pressure and temperature and its implications for the stability of icosahedrite (2014)

The first natural-occurring quasicrystal, icosahedrite, was recently discovered in the Khatyrka meteorite, a new CV3 carbonaceous chondrite. Its finding raised fundamental questions regarding the effects of pressure and temperature on the kinetic and thermodynamic stability of the quasicrystal structure relative to possible isochemical crystalline or amorphous phases. Although several studies showed the stability at ambient temperature of synthetic icosahedral AlCuFe up to ~35 GPa, the simultaneous effect of temperature and pressure relevant for the formation of icosahedrite has been never investigated so far. Here we present in situ synchrotron X-ray diffraction experiments on synthetic icosahedral AlCuFe using multianvil device to explore possible temperature-induced phase transformations at pressures of 5 GPa and temperature up to 1773 K. Results show the structural stability of i-AlCuFe phase with a negligible effect of pressure on the volumetric thermal expansion properties. In addition, the structural analysis of the recovered sample excludes the transformation of AlCuFe quasicrystalline phase to possible approximant phases, which is in contrast with previous predictions at ambient pressure. Results from this study extend our knowledge on the stability of icosahedral AlCuFe at higher temperature and pressure than previously examined, and provide a new constraint on the stability of icosahedrite.
OPERATION PLANNING OF CORRECTION OSTEOTOMIES IN 3D (2002)

This paper discusses an operation planning system for correction osteotomies. It is based on 3D data obtained from CT/MR of the bone and it allows to perform a 3D planning. The physician can individually determine anatomical landmarks for measuring geometric parameters of the bone like length, angle and torsion angle. In a virtual scene he or she can set a single cut or can remove/insert a wedge, dissecting the bones. The bone parts can be rearranged in 3D space. Optimization routines allow that the physician only defines the position of the cut, the orientation of the cut plane, the rearrangement of the bone and the optimization for the maximal overlap of the cortical bone can be processed automatically. The system is currently in use at the Trauma department at the University of Ulm. A case study shows the results by applying this system.
Transient analysis of cumulative measures of markov model behavior (1989)

Markov chains and Markov reward models provide are useful for modeling fault-tolerant, distributed and multi-processor systems. In this paper, we consider the transient analysis of “cumulative” or “integral” measures of Markov and Markov reward model behavior. These measure include “interval availability” and “expected accumulated reward” over a finite horizon. We consider two methods for numerical model evaluation: Uniformization and differential equation solution. We use a numerical experiment to compare the algorithms' performance as a function of model size, accuracy, and stiffness. Contrary to “folk wisdom”, we observe that cumulative measure solver behavior is usually similar to that seen in instantaneous measure analysis. However, for large time values, cumulative measures do not converge to steady-state values, leading to numerical difficulties like overflow and slow convergence. These problems can be avoided by directly solving time-averaged equations
Heterogeneous Integration of CMOS Sensors and Fluidic Networks Using Wafer-Level Molding (2018)

Direct sensing in liquids using CMOS-integrated optical and electrical sensors is attractive for lab-on-chip applications, where close physical proximity between sample and sensor can obviate optical lenses, enhance electrical sensitivity, and decrease noise due to parasitics. However, controlled delivery of fluid samples to the chip surface presents an ongoing challenge for lab-on-CMOS development, where traditional wire-bond packaging prevents integration of planar microfluidics. In this paper, we present a method for scalable heterogeneous integration of microfluidic channels and silicon-integrated circuit substrates using a commercial fan-out wafer-level packaging approach. The planar surface supports multiple approaches for fluidic integration; we present both a stacked laser-cut fluidic assembly and the fabrication of monolithic SU-8 microchannels over the IC surface. As a proof-of-principle, both electrical and fluidic routing are provided to a custom 0.18-m CMOS optical sensor IC, and optical transmission and fluorescence measurement experiments are demonstrated.
Inside-outside stereoisomerism. II. Synthesis of the carbocyclic ring system of the ingenane diterpenes via the intramolecular dioxolenone photocycloaddition (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInside-outside stereoisomerism. II. Synthesis of the carbocyclic ring system of the ingenane diterpenes via the intramolecular dioxolenone photocycloadditionJeffrey D. Winkler, Kevin E. Henegar, and Paul G. WilliardCite this: J. Am. Chem. Soc. 1987, 109, 9, 2850–2851Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00243a062https://doi.org/10.1021/ja00243a062research-articleACS PublicationsRequest reuse permissionsArticle Views511Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Sensing Gallium Nitride HEMT junction temperature using gate drive output transient properties (2016)

The gate drive output transient properties of conventional power semiconductors (Silicon MOSFET, Silicon-Carbide MOSFET, and Silicon IGBT) have been studied for online junction temperature (Tj) sensing. This method utilizes the semiconductor intrinsic Tj-dependent characteristics and the gate drive output dynamics. In this paper, the method is applied to Gallium Nitride (GaN) high electron mobility transistors (HEMTs). To demonstrate the GaN HEMT Tj sensing, two passivated die HEMTs are implemented in a half-bridge and driven by two integrated push-pull type gate drives. The gate drive turn-on current transient is used for GaN HEMT Tj sensing. The “gate drive-HEMT” switching properties are modeled to explain the Tj-dependent gate drive output dynamics. Experimental results are compared with LTSpice simulations.
Supplementary Figure 1 from Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in <i>EGFR</i>-Mutant Lung Cancer (2023)

&lt;p&gt;Supplementary Figure S1. Trametinib sensitivity of EGFR mutant NSCLC cell lines and inhibition of ERK dependent genes. (A) Inhibition of ERK1/2 was assessed in each cell line after 8 hours of treatment followed by immunoblot for total and phosphorylated ERK1/2. Hsp90 was used as a loading control. (B) The viability of PC9, HCC4006, HCC2279 and HCC2935 cells was assessed after 72 hours. (C) PC9 GR4 (EGFR Del746_A750/T790M) cells were treated with DMSO (Media), 100 nM WZ4002, 30 nM trametinib or a combination thereof for 8 hours or (D) 24 hours and ERK1/2 dependent gene transcription was assessed by quantitative PCR, asterisk, p &lt; 0.05 by one-tailed t-test.&lt;/p&gt;
Lactate Assay Application Using a New Comprehensive Bioelectronic System for Point-of-Care Applications (2016)

Serum lactate is an important measurement taken in critical care settings for screening of lactic acidosis and as an indicator of sepsis. In addition, serial lactate testing provides essential information for evaluating therapy effectiveness and informing treatment decisions of critically ill patients at the point-of-care (POC). In this work, the performance of the Ohmx POC eDx Lactate test was evaluated and compared to the Nova Biomedical Lactate Plus Meter. This assay is introduced as the first test for a comprehensive bioelectronic POC instrument currently in development by Ohmx that will also offer procalcitonin and C-reactive protein tests for sepsis monitoring. Clinical sample testing shows an average recovery of 99% for measured sample lactate concentration relative to the Lactate Plus Meter for 60 samples. Correlation by Passing–Bablok regression yielded Lactate Plus = 1.03 × Ohmx eDx + 0.22, r = 0.984 (n = 60; range of lactate values, 0.7–6.0 mmol/L). The lower limit of detection was 0.1 mmol/L. The lower and upper limits of quantification were 0.208 and 20 mmol/L, respectively. Intraday and total imprecision (% coefficient of variation) ranges from 5.7% to 9.1% across the assay range (0.2–20 mmol/L). These collective data clinically validate the Ohmx eDx Lactate assay and demonstrate the system's robust performance comparable to the Food and Drug Administration–cleared Lactate Plus Meter by Nova Biomedical.
Development of HEK-293 Cell Lines Constitutively Expressing Flaviviral Antigens for Use in Diagnostics (2022)

Flaviviruses are important human pathogens worldwide. Diagnostic testing for these viruses is difficult because many of the pathogens require specialized biocontainment. To address this issue, we generated 39 virus-like particle (VLP)- and nonstructural protein 1 (NS1)-secreting stable cell lines in HEK-293 cells of 13 different flaviviruses, including dengue, yellow fever, Japanese encephalitis, West Nile, St. Louis encephalitis, Zika, Rocio, Ilheus, Usutu, and Powassan viruses. Antigen secretion was stable for at least 10 cell passages, as measured by enzyme-linked immunosorbent assays and immunofluorescence assays. Thirty-five cell lines (90%) had stable antigen expression over 10 passages, with three of these cell lines (7%) increasing in antigen expression and one cell line (3%) decreasing in antigen expression. Antigen secretion in the HEK-293 cell lines was higher than in previously developed COS-1 cell line counterparts. These antigens can replace current antigens derived from live or inactivated virus for safer use in diagnostic testing. <b>IMPORTANCE</b> Serological diagnostic testing for flaviviral infections is hindered by the need for specialized biocontainment for preparation of reagents and assay implementation. The use of previously developed COS-1 cell lines secreting noninfectious recombinant viral antigen is limited due to diminished antigen secretion over time. Here, we describe the generation of 39 flaviviral virus-like particle (VLP)- and nonstructural protein 1 (NS1)-secreting stable cell lines in HEK-293 cells representing 13 medically important flaviviruses. Antigen production was more stable and statistically higher in these newly developed cell lines than in their COS-1 cell line counterparts. The use of these cell lines for production of flaviviral antigens will expand serological diagnostic testing of flaviviruses worldwide.
Multi-Resolution Data Fusion for Super-Resolution Electron Microscopy (2017)

Perhaps surprisingly, all electron microscopy (EM) data collected to date is less than a cubic millimeter - presenting a huge demand in the materials and biological sciences to image at greater speed and lower dosage, while maintaining resolution. Traditional EM imaging based on homogeneous raster scanning severely limits the volume of high-resolution data that can be collected, and presents a fundamental limitation to understanding physical processes such as material deformation and crack propagation. We introduce a multi-resolution data fusion (MDF) method for super-resolution computational EM. Our method combines innovative data acquisition with novel algorithmic techniques to dramatically improve the resolution/volume/speed trade-off. The key to our approach is to collect the entire sample at low resolution, while simultaneously collecting a small fraction of data at high resolution. The high-resolution measurements are then used to create a material-specific model that is used within the “plug-and-play” framework to dramatically improve resolution of the low-resolution data. We present results using FEI electron microscope data that demonstrate super-resolution factors of 4x-16x, while substantially maintaining high image quality and reducing dosage.
A ray tracing method for predicting path loss and delay spread in microcellular environments (2003)

The ability to predict path loss and delay spread is crucial for determining coverage and for planning interference reduction strategies in wireless radio system design. A promising theoretical method to accurately predict these channel characteristics in microcells is presented. The method uses modified geometrical optics to evaluate average path loss and delay spread. Quantitative building data, such as location, height, and electrical properties, are used to determine the individual multipath component amplitudes and delays. Preliminary verification of the technique against measured data has been conducted. The results illustrate that accurate path loss prediction is possible, with predicted values being within 5 dB of the measured values. As a result of this study, a computer program is being developed to automate the prediction process. The technical issues required for automated propagation prediction are presented. The ray optics model, computer ray tracing techniques, and building data requirements are also described. Comparisons between simulations and measurements are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6) (2012)

The importance of E3 ubiquitin ligases, involved in the degradation of misfolded proteins or promotion of protein-protein interaction, is increasingly recognized in neurodegeneration. TDP-43 is a predominantly nuclear protein, which regulates the transcription of thousands of genes and binds to mRNA of the E3 ubiquitin ligase Parkin to regulate its expression. Wild type and mutated TDP-43 are detected in ubiquitinated forms within the cytosol in several neurodegenerative diseases. We elucidated the mechanisms of TDP-43 interaction with Parkin using transgenic A315T mutant TDP-43 (TDP43-Tg) mice, lentiviral wild type TDP-43, and Parkin gene transfer rat models. TDP-43 expression increased Parkin mRNA and protein levels. Lentiviral TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated Lys-48 and Lys-63-linked ubiquitin to TDP-43 and led to cytosolic co-localization of Parkin with ubiquitinated TDP-43. Parkin and TDP-43 formed a multiprotein complex with HDAC6, perhaps to mediate TDP-43 translocation. In conclusion, Parkin ubiquitinates TDP-43 and facilitates its cytosolic accumulation through a multiprotein complex with HDAC6.
Optimized automated cardiac MR scar quantification with GAN‐based data augmentation (2022)

A cascaded deep learning-based pipeline trained with augmentation by synthetically generated data leads to myocardium and scar segmentations that are similar to the manual operator, and outperforms direct segmentation without the synthetic images.