gebhart/patrepeval huggingface dataset:
Structural dynamics of transfer ribonucleic aic carbon-13 nuclear magnetic resonance of [13C]methyl-enriched pure species (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural dynamics of transfer ribonucleic aic carbon-13 nuclear magnetic resonance of [13C]methyl-enriched pure speciesRandall A. Kopper, Paul G. Schmidt, and Paul F. AgrisCite this: Biochemistry 1983, 22, 6, 1396–1401Publication Date (Print):March 15, 1983Publication History Published online1 May 2002Published inissue 15 March 1983https://doi.org/10.1021/bi00275a012RIGHTS & PERMISSIONSArticle Views19Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (725 KB) Get e-Alerts Get e-Alerts
Transport Phenomena and Giant Magnetoresistance for an Annealed Co-Al-O Granular Film (1999)

A Co-Al-O granular thin film was prepared on glass substrates by reactive sputtering method with mixed gas of Ar+O2. The sample was annealed at 300°C for various annealing time to change the microstructure. The temperature dependence of electrical resistivity (ρ) shows the relationship of logp versus T-1/2 for the sample annealed for 1 and 6 hours. However, the sample annealed for 38 hours shows the relationship of logρ versus T-1/4, which represents a significant change in the transport mechanism. Although the transport mechanism was changed, GMR appeared for 38hours-annealed sample. The magnitude of GMR decreases with increasing annealing time. Particularly, GMR reveals a noticeable decrease at low temperatures on annealing.
Engineering of a green‐light inducible gene expression system in S ynechocystis sp. PCC 6803 (2013)

In order to construct a green-light-regulated gene expression system for cyanobacteria, we characterized a green-light sensing system derived from Synechocystis sp. PCC6803, consisting of the green-light sensing histidine kinase CcaS, the cognate response regulator CcaR, and the promoter of cpcG2 (PcpcG 2 ). CcaS and CcaR act as a genetic controller and activate gene expression from PcpcG 2 with green-light illumination. The green-light induction level of the native PcpcG 2 was investigated using GFPuv as a reporter gene inserted in a broad-host-range vector. A clear induction of protein expression from native PcpcG 2 under green-light illumination was observed; however, the expression level was very low compared with Ptrc , which was reported to act as a constitutive promoter in cyanobacteria. Therefore, a Shine-Dalgarno-like sequence derived from the cpcB gene was inserted in the 5' untranslated region of the cpcG2 gene, and the expression level of CcaR was increased. Thus, constructed engineered green-light sensing system resulted in about 40-fold higher protein expression than with the wild-type promoter with a high ON/OFF ratio under green-light illumination. The engineered green-light gene expression system would be a useful genetic tool for controlling gene expression in the emergent cyanobacterial bioprocesses.
Rôles physiologiques de l’AMP-activated protein kinase(AMPK) (2003)

malades (srum anti-lymphocytaire, fludarabine, ciclosporine, mycophnolate moftil, etc.), peut inhiber une rponse immune efficace, et met donc l'accent sur la ncessit d'adjoindre l'allo-CSH d'autres stratgies d'immunothrapie comme la vaccination par cellules dendritiques ou la manipulation des effecteurs avant rinjection des lymphocytes du donneur, capables d'induire long terme un vritable effet GVT avec contrle durable et efficace de la maladie. Segregating effectors for graft versus host and graft versus tumor reactions
Application of lanthanide shift reagents to alkyl fluorides (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of lanthanide shift reagents to alkyl fluoridesJoseph San Filippo Jr., Ralph G. Nuzzo, and Louis J. RomanoCite this: J. Am. Chem. Soc. 1975, 97, 9, 2546Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/ja00842a043https://doi.org/10.1021/ja00842a043research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EMPIRICAL EVALUATION OF EXPONENTIAL AND INDEPENDENCE ASSUMPTIONS IN QUEUEING MODELS OF MANUFACTURING SYSTEMS (1999)

This paper presents actual data (processing times, interarrival times, cycles‐between‐failures, and time‐to‐repair) from two automotive body welding lines. The purpose is twofold. First, to help researchers focus their work on realistic problems, we exhibit the nature of randomness actually found in two industrial manufacturing systems and provide a data source for realistic probability distributions. Second, we assess the validity of two common assumptions regarding this randomness in automotive manufacturing. Many queueing network models assume that certain random variables are independent and exponentially distributed. Though often reasonable, the primary motivation for the independence and exponentiality assumptions is mathematical tractability.
Optical Network Programmability - Requirements and Applications (2018)

Datacenter operators and internet content providers require optical network programmability to efficiently interconnect distributed datacenters. This paper describes the requirements, applications and use cases for optical network programmability. Based on application scenarios, open northbound APIs with different levels of control and abstraction to address different network operator requirements which are defined. For their illustration, use cases for optical network programmability show current research directions.
VTR 8 (2020)

Developing Field-programmable Gate Array (FPGA) architectures is challenging due to the competing requirements of various application domains and changing manufacturing process technology. This is compounded by the difficulty of fairly evaluating FPGA architectural choices, which requires sophisticated high-quality Computer Aided Design (CAD) tools to target each potential architecture. This article describes version 8.0 of the open source Verilog to Routing (VTR) project, which provides such a design flow. VTR 8 expands the scope of FPGA architectures that can be modelled, allowing VTR to target and model many details of both commercial and proposed FPGA architectures. The VTR design flow also serves as a baseline for evaluating new CAD algorithms. It is therefore important, for both CAD algorithm comparisons and the validity of architectural conclusions, that VTR produce high-quality circuit implementations. VTR 8 significantly improves optimization quality (reductions of 15% minimum routable channel width, 41% wirelength, and 12% critical path delay), run-time (5.3× faster) and memory footprint (3.3× lower). Finally, we demonstrate VTR is run-time and memory footprint efficient, while producing circuit implementations of reasonable quality compared to highly-tuned architecture-specific industrial tools—showing that architecture generality, good implementation quality, and run-time efficiency are not mutually exclusive goals.
Ion-cyclotron-resonance mass spectrometry with a microwave plasma source (1991)

The feasibility of coupling an electron-cyclotron-resonance (ECR) plasma-processing reactor directly to an omegatron mass spectrometer is demonstrated. The ECR plasma is created in a chamber that is coupled to the omegatron through a small, grounded orifice. Ions created in the ECR chamber flow along the magnetic field into the omegatron analysis cell, and the mass spectrum of these ions is recovered. Using this technique the mass spectra of both single-component (He) and two-component (N/sub 2/ and N) ECR plasmas were measured. The mass resolution as a function of the omegatron excitation voltage for He and N/sub 2/ plasmas was obtained and found to compare well to theoretical calculations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Delineation Of Barrett’S Neoplasia Using Deep Neural Networks (2021)

Aims Accurate delineation of Barrett’s neoplasia is crucial to detection and planning of endoscopic resection. However, this task can be very challenging. The aim of this study is to develop and validate an artificial intelligence algorithm based on deep neural networks for delineation of Barrett’s neoplasia.
High Chrome Refractory Characterization: Part II . Accumulation of Spinel Corrosion Deposits in Radioactive Waste Glass Melters (2015)

High Cr 2 O 3 containing Monofrax ™ K‐3 is a robust refractory that is used in radioactive waste glass melters worldwide. Monofrax ™ K‐3 contains highly reduced phases. Conversely, many of the radioactive feeds being processed are highly oxidizing. The K‐3 refractory corrosion rates in oxidizing (high nitrate) feeds were ~1.8–2.8 times higher than the rates determined using reducing feeds. The corrosion product formed is a mixture of spinel and glass (slag) that can accumulate on the melter floor. A methodology to calculate the depth of slag deposits from refractory corrosion is presented and verified with slag measurements from the Defense Waste Processing Facility ( DWPF ) melter after it had processed oxidized feeds for 1.75 years. The calculations show that had the facility continued to process oxidized feeds the melter lifetime (based on when the deposits could have reached and blocked the pour spout riser) would have been ~4.5 years. The DWPF changed to a reducing flow sheet after ~3 years of operation. The lifetimes of Melter #1 and Melter #2, assuming a failure due to pour spout blockage, are calculated as 7.7–12 years based on corrosion rates measured with reducing feeds. Lifetimes of 9 and &gt;11 years have actually been achieved.
A strategy for screening anti‐tumor drugs utilizing oncogenes encoded in retroviral vectors (1996)

A novel strategy for isolating potential anti-tumor drugs is presented. It is predicated on the idea that future anti-tumor drugs will be specific inhibitors of the signal-transduction pathways responsible for cell proliferation. Briefly, retroviral vectors are used to introduce focus-forming oncogenes into a test population of target cells, which are grown to confluence and treated with signal-transduction inhibitors. The inhibitors are screened for the ability to suppress the development of transformed foci without killing the confluent monolayer of non-transformed quiescent cells. For this work, a panel of inhibitors was first screened against the oncogene ras. The protein kinase C (PKC) inhibitor CGP 41251 and the protein tyrosine kinase (PTK) inhibitor CGP 45047 suppressed ras-induced focus formation and left a viable monolayer of quiescent cells. Focus inhibition was reversible; conversely, drug addition to developing foci retarded further expansion. CGP 41251 generally blocked proliferation of ras or control cells, suggesting that oncogenes cannot substitute for PKC. PTK inhibitors erbstatin and CGP 520 and phosphatase inhibitor okadaic acid failed to inhibit focus formation at concentrations toxic to the monolayer. Lavendustin A and CGP 47778A showed neither focus inhibition nor toxicity. In the complementary screen, a single inhibitor (CGP 41251) was tested against several oncogenes, including src, raf and polyomavirus middle T antigen. Focus formation by all oncogenes was suppressed. The strategy has several advantages over current drug-screening assays, and it can be adapted to large-scale screening with many drugs and many oncogenes. © 1996 Wiley-Liss, Inc.
Photonic Crystals for Infrared Nonlinear Optics (2009)

Abstract : Here we summarize our progress in the development of 2- to 5-micron wavelength supercontinuum sources through grant number FA8650-05-C-5426 over the life of the program. The key developments over the past 3 years include 1) A proof-of-principle demonstration of a novel, efficient mid-IR Raman laser source in silica materials system, yielding efficient spectral transfer to 2.41 microns. (The demonstrated system can be naturally extended in wavelength to 5microns and beyond); 2) The development of nonlinear-optical simulation capabilities; 3) Progress toward the development of low loss, highly nonlinear chalcogenide fibers; 4) Novel interferometric measurement techniques to examine the integrity and loss mechanisms of such fibers; and 5) Nonlinear studies of chalcogenide fibers and prospects for extending our cascaded Raman source to longer wavelengths.
Rücktitelbild: Under‐5‐Minute Immunoblot Assays by Vortex Fluidic Device Acceleration (Angew. Chem. 23/2022) (2022)

Eine neue Assaytechnik, genannt „vortex fluidic device accelerated immunoblot assay“ (VAIA), reduziert die Bearbeitungszeit von Immunoblots von fast 2 Stunden auf weniger als 5 Minuten. In ihrer Zuschrift (DOI: 10.1002/ange.202202021) zeigen Gregory A. Weiss et al. die breite Anwendbarkeit und das Potenzial von VAIA. Das Bild zeigt in künstlerischer Form, wie die einzigartige Dünnfilm-Mikrofluidik des Vortex-Fluidikapparats die Verarbeitung von Immunoblots beschleunigen kann.
Lightweight forensic video watermarking to enable premium content consumption on mobile devices (2014)

Content owners are reluctant to deliver premium content to open devices due to the risk of piracy and the corresponding potential for loss of revenue. To lift this deadlock, there is increasing interest in incorporating watermarking-based tracing mechanisms onto mobile devices such as smart phones and tablets. The scarcity of resources calls for innovative watermarking paradigms. In this demo, we will exemplify how two-step bitstream video watermarking could be exploited to address this challenge and why it needs to be adapted to cope with the characteristics of HTTP adaptive streaming.
Off-Normal Patterned Etching Through Suspended Membranes. (2014)

Abstract not provided.
Cationic polymerizations by aromatic initiating systems. II. Correlation between cationic model and polymerization reactions with the p‐CH3C6H4CH2Cl/Et3Al system (1979)

Abstract Model experiments and subsequent polymerization runs have been carried out to elucidate the mechanism of cationic olefin polymerizations initiated by aromatic carbenium ions. Thus, the p ‐methylbenzylation of 2,4,4‐trimethyl‐1‐pentene, a nonpolymerizable model olefin for isobutylene, was investigated by using the p ‐CH 3 C 6 H 4 CH 2 Cl/Et 3 Al initiating system and CH 2 Cl 2 solvent under various conditions. All the important organic reaction products were identified and most of them, quantitatively determined. Analysis of the nature of the products and their distributions gave important mechanistic information about the chemistry of elementary events and their relative rates; for example, hydridation and ethylation by the Et 3 AlCl ⊖ counteranion of various cations occurs and these processes mimic termination in carbocationic polymerizations. Hydridation and ethylation are much faster than proton elimination (chain transfer in polymerization) and experimental conditions (e.g., Al/Cl ratio and temperature) influence the relative rates of these processes. According to model experiments, the p ‐CH 3 C 6 H 4 CH 2 Cl/Et 3 Al system may initiate olefin (isobutylene) polymerization; chain transfer to monomer should be relatively unimportant, but rapid hydridation or ethylation should reduce the kinetic chain and give low conversions. Predictions derived from model experiments were substantiated by polymerizations with isobutylene and the aromatic initiating system.
Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3 (2017)

Interleukin-1 (IL-1) signaling induces the formation of Lys63-linked ubiquitin (K63-Ub) chains, which are thought to activate the 'master' protein kinase TGFβ-activated kinase 1 (TAK1) by interacting with its TAK1-binding 2 (TAB2) and TAB3 subunits. Here, we report that IL-1β can also activate the TAB1-TAK1 heterodimer present in TAB2/TAB3 double knockout (DKO) IL-1 receptor-expressing cells. The IL-1β-dependent activation of the TAB1-TAK1 heterodimer in TAB2/3 DKO cells is required for the expression and E3 ligase activity of tumor necrosis factor receptor-associated factor 6 (TRAF6) and is reduced by the small interfering RNA (siRNA) knockdown of ubiquitin conjugating 13 (Ubc13), an E2-conjugating enzyme that directs the formation of K63-Ub chains. IL-1β signaling was restored to TAB1/2/3 triple KO cells by the re-expression of either TAB1 or TAB2, but not by an ubiquitin binding-defective mutant of TAB2. We conclude that IL-1β can induce the activation of TAK1 in two ways, only one of which requires the binding of K63-Ub chains to TAB2/3. The early IL-1β-stimulated, TAK1-dependent activation of p38α mitogen-activated protein (MAP) kinase and the canonical IκB kinase (IKK) complex, as well as the NF-κB-dependent transcription of immediate early genes, was similar in TAB2/3 DKO cells and TAB2/3-expressing cells. However, in contrast with TAB2/3-expressing cells, IL-1β signaling was transient in TAB2/3 DKO cells, and the activation of c-Jun N-terminal kinase 1 (JNK1), JNK2 and p38γ was greatly reduced at all times. These observations indicate a role for TAB2/3 in directing the TAK1-dependent activation of MAP kinase kinases that switch on JNK1/2 and p38γ MAP kinases. These observations and the transient activation of the TAB1-TAK1 heterodimer may explain why IL-1β-dependent IL-8 mRNA formation was abolished in TAB2/3 DKO cells.
Supplementary Figures 1-5, Tables 1-2 from Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells (2023)

Supplementary Figures 1-5, Tables 1-2 from Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
Cognitive Radio for Ka Band Satellite Communications (2014)

The satellite communication data traffic is increasing dramatically over the coming years. High throughput multibeam satellite networks in Ka band are potentially able to accommodate the upcoming high data rate demands. However, there is only 500 MHz of exclusive band for download and the same amount for upload. This spectrum shortage impose a barrier in order to satisfy the increasing demands. Cognitive satellite communication in Ka band is considered in this paper in order to potentially provide an additional 4.4 GHz bandwidth for downlink and uplink fixed-satellite-services. In this way, it is expected that the problem of spectrum scarcity for future generation of satellite networks is alleviated to a great extent. The underlying scenarios and enabling techniques are discussed in detail, and finally we investigate the implementation issues related to the considered techniques.
Optimal Effectiveness of BDNF for Fetal Nigral Transplants Coincides with the Ontogenic Appearance of BDNF in the Striatum (1998)

Transplantation of fetal nigral dopamine neurons into the caudate and putamen of Parkinson’s disease patients produces limited symptomatic relief. One approach to augment the outgrowth and function of nigral grafts includes exposure of the graphs to neurotrophic factors; however, the temporal requirements for optimizing these actions are unknown. The present study characterized the ontogeny of brain-derived neurotrophic factor (BDNF) in the rat striatum and used this information to define and evaluate three distinct periods of BDNF infusion into fetal nigral grafts transplanted into the striatum of rats with experimental Parkinson’s disease. At postnatal day 1 (P1), BDNF and dopamine were measured at 17 and 27% of peak levels, respectively, that occurred at P27 for both. Both compounds showed their greatest surge between P7 and P20, increasing from 40% to ∼95% of peak levels. Exogenous BDNF infused into transplants during weeks 1 and 2 after the transplantation, which coincide with the developmental period embryonic day 14 (E14)–P7 for transplanted tissue, did not improve rotational behavior or enhance fiber outgrowth of transplanted dopamine neurons. Delaying the BDNF infusion until transplanted tissue was approximately P8–P21 greatly enhanced the effect on rotational behavior and doubled the area of dopamine fiber outgrowth from the transplants. Delaying the infusion until transplanted tissue was approximately P36–P49 failed to augment fiber outgrowth and decreased the behavioral function of transplants. Thus, the optimal effect of exogenous BDNF on the development of dopamine neurons in fetal nigral transplants occurs at a postnatal age when endogenous dopamine and BDNF show the greatest increases during the normal development of the striatum.
CO Disproportionation on a Nanosized Iron Cluster (2009)

First-principles electronic structure calculations, fully incorporating the effects of spin polarization and noncollinear magnetic moments, have been used to investigate CO disproportionation on an isolated Fe cluster. After CO dissociation, which occurs on a vertex between the facets, O atoms remain on the surface while C atoms move into the cluster as the initial step toward carbide formation. The lowest CO dissociation barrier found (0.77 eV) is lower than that on most of the studied Fe surfaces. Several possible paths for CO2 formation were identified. The lowest reaction barrier was 1.08 eV.