gebhart/patrepeval huggingface dataset:
Molecular Allergen-Specific IgE Recognition Profiles and Cumulative Specific IgE Levels Associated with Phenotypes of Cat Allergy (2022)

Cat allergy is a major trigger factor for respiratory reactions (asthma and rhinitis) in patients with immunoglobulin E (IgE) sensitization. In this study, we used a comprehensive panel of purified cat allergen molecules (rFel d 1, nFel d 2, rFel d 3, rFel d 4, rFel d 7, and rFel d 8) that were obtained by recombinant expression in <i>Escherichia coli</i> or by purification as natural proteins to study possible associations with different phenotypes of cat allergy (i.e., rhinitis, conjunctivitis, asthma, and dermatitis) by analyzing molecular IgE recognition profiles in a representative cohort of clinically well-characterized adult cat allergic subjects (<i>n</i> = 84). IgE levels specific to each of the allergen molecules and to natural cat allergen extract were quantified by ImmunoCAP measurements. Cumulative IgE levels specific to the cat allergen molecules correlated significantly with IgE levels specific to the cat allergen extract, indicating that the panel of allergen molecules resembled IgE epitopes of the natural allergen source. rFel d 1 represented the major cat allergen, which was recognized by 97.2% of cat allergic patients; however, rFel d 3, rFel d 4, and rFel d 7 each showed IgE reactivity in more than 50% of cat allergic patients, indicating the importance of additional allergens in cat allergy. Patients with cat-related skin symptoms showed a trend toward higher IgE levels and/or frequencies of sensitization to each of the tested allergen molecules compared with patients suffering only from rhinitis or asthma, while there were no such differences between patients with rhinitis and asthma. The IgE levels specific to allergen molecules, the IgE levels specific to cat allergen extract, and the IgE levels specific to rFel d 1 were significantly higher in patients with four different symptoms compared with patients with 1-2 symptoms. This difference was more pronounced for the sum of IgE levels specific to the allergen molecules and to cat extract than for IgE levels specific for rFel d 1 alone. Our study indicates that, in addition to rFel d 1, rFel d 3, rFel d 4, and rFel d 7 must be considered as important cat allergens. Furthermore, the cumulative sum of IgE levels specific to cat allergen molecules seems to be a biomarker for identifying patients with complex phenotypes of cat allergy. These findings are important for the diagnosis of IgE sensitization to cats and for the design of allergen-specific immunotherapies for the treatment and prevention of cat allergy.
Experimental-Numerical Comparison for a High-Density Data Center: Hot Spot Heat Fluxes in Excess of 500 W/ft $^{2}$ (2009)

This paper uses previously published experimental data to present a comparison between test results and numerical simulations. The example considered is a large 7400 ft <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> data canter that houses over 130 heat-producing racks (1.2 MW) and 12 air conditioning units. Localized hot spot heat fluxes were measured to be as high as 512 W/ft <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (5.5 kW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) for a 400 ft <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (37 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) region. A numerical model based on computational fluid dynamics (CFD) was constructed using inputs from the measurements. The rack inlet air temperature was considered to be the basis for experimental versus numerical comparison. The overall mean rack inlet temperature predicted numerically at a height of 1.75 m is within 4degC of the test data with a rack-by-rack standard deviation of 3.3degC.
Expression pattern of CEA-related cell adhesion molecules in human pulmonary epithelia in relation to inflammatory stimuli and to the interaction with Moraxella catarrhalis (2010)

Introduction: CEACAM1 is an important human receptor for host-pathogen interaction. The pulmonary pathogen Moraxella catarrhalis has developed the specific cell surface protein UspA1 to mediated adhesion to CEACAM1. Ligation of CEACAM1 is leading to a reduction of the TLR2-triggered immune response. Besides CEACAM1, expression of CEACAM5, 6 and 7 has been described in epithelial cells derived from the gastrointestinal tract. However, regulation and expression pattern of CEACAMs in the human pulmonary tract have never been studied in detail.
Minimum-EVM N-continuous OFDM (2016)

The N-continuous precoder for the suppression of OOB emission in OFDM systems that minimizes the EVM is introduced. We show that the minimum in-band interference due to the introduced precoding approach is 3 dB less than the inband interference of existing N-continuous precoders. Moreover, we introduce a novel practical block precoder that approaches the performance of the suggested optimal precoder. We analyze the spectrum of the OFDM signal after block precoding, the inband interference due to block precoding and the effect of block precoding on the BER. The price to pay for block precoding is the computational complexity that grows linearly with the block size.
Glossiness sensor and its application for pearl glossiness measuring system. (1990)

As the glossiness of spherical specimens, we proposed previously the indistinctness-degree glossiness G!D and fabricated the instrument for measuring GID. However, in this old instrument, fairly errors of the GD were caused by the deviation of the specimen holding position. Thus, an integration type indistinctness-degree glossiness GID-M was proposed in this paper. Next, an intelligent type sensor for measuring the GID-M was developed. Using the new sensor, we constructed a pearl glossiness measuring system. In this system, the measuring errors of the glossiness caused by the deviation of the pearl holding are reduced, and the measuring time per one pearl is as short as 1.5 s.
Computer-Assisted Bronchoscopy: Aims and Research Perspectives (1995)

The introduction of spiral computed tomography (CT) of the thoracic cavity has allowed the development of new visualization tools. These tools provide a three-dimensional (3-D) endoluminal reconstruction of the tracheobronchial tree, as it would be viewed through a fibroscopic instrument. However, 3-D reconstruction techniques cannot replace conventional fibroscopy, which remains indispensable for obtaining histological samples. Furthermore, when CT-detected mediastinal or parenchymal lesions are not seen during fiberoptic bronchoscopy, guiding transbronchial needle biopsy is a major challenge.Computer-guided transbronchial biopsy involves the fusion of image data from both CT slices and bronchoscopic video sequences. This fusion is described in this paper in two parts. First, we present a segmentation process, using mathematical morphology operators, in order to analyze the video sequence and localize the bronchoscopic camera within the tracheobronchial tree. Second, we present tools used to match this localization knowledge with CT data. Finally, we produce images that create a bronchoscopic augmented reality, using elements extracted from the CT examination.
Supplementary File 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase (2023)

&lt;p&gt;Supplementary File 1.&lt;/p&gt;
Optimizing Network Performance In Replicated Hosting (2006)

Most important commercial Web sites maintain multiple replicas of their server infrastructure to increase both reliability and performance. In this paper, we study how many replicas should be used and where they should be placed in order to improve client network performance, including both the latency (e.g., round-trip time) between clients and the replicas, and the bandwidth performance between them. This study is based on a large scale measurement study from an 18-node infrastructure, which reveals for the first time the distribution of today's Internet end-user access bandwidth. For example, we find that 50% of end users have access bandwidth less than 4.2Mbps. Using a greedy algorithm, we show that the first five replicas dominate latency optimization in our measurement infrastructure, while the first two replicas dominate bandwidth optimization. We also found that geographic diversity does not help as much for bandwidth optimization as it does for latency. To determine the proper trade-off between latency and bandwidth, we use a simplified TCP model to show that, when content size is less than 10Kb, the deployment should focus on optimizing latency, while for content sizes larger than 1 Mb, the deployment should focus on optimizing bandwidth.
Development of a chip-to-chip optical interconnect system (2013)

We present the design and simulation of a high efficient optical chip-to-chip coupling structure. The position tolerance (3dB coupling efficiency) can be as large as 1.0 μm when the polymer waveguide diameter equals 6.0 μm.
Deformation and Rheology of Co-Continuous Blends (2008)

Model immiscible blends were tested for morphology and rheological properties. With planar compression comes a loss of co‐continuity. Transient viscosity overshoot is larger with the blend than with either component. Storage modulus is affected by the blend morphology at low shear rates. Shear viscosity at high shear rates is 30 percent lower than either component. Normal stress and viscosity are both larger than the mean between the phases, and die swell with the blend is larger than with either component.
Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting (2015)

Onchocerciasis is an infection caused by the filarial worm Onchocerca volvulus, which can eventually result in blindness. The lack of an effective macrofilaricide and the possible development of ivermectin-resistant strains of O. volvulus necessitate the need for alternative treatment strategies. We have shown that targeting the L3-stage-specific chitinase OvCHT1 impairs the shedding of the filarial cuticle. In our continued efforts to discover OvCHT1 inhibitors, we identified the β-carboline alkaloid scaffolding as a chitinase inhibitor that is capable of penetrating the worm cuticle. Herein, we disclose the rich polypharmacology of the β-carboline class of compounds as an approach to abrogate the molting of the parasite and thus the initiation of infection in the human host.
Optical Non-Reciprocity in Optomechanical Structures (2009)

We propose non-reciprocal optomechanical devices where light and matter interact via momentum exchange with a movable mirror. Non-reciprocity arises by utilizing the direction of linear momentum of light to differentiate forward and backward propagating light.
Real-time computing cornerstones: a system engineer's view (2002)

Common attributes are found in both military and commercial real-time systems. The existence of these common threads suggests that there may be key quantitative system design considerations that undergird large scale, real-time system design. Identifying and quantifying these key aspects early in a program is important in insuring the success of a design. This paper suggests a candidate list of such computing properties, or cornerstones, by which every real-time system is defined and constrained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characterization of aN-Bromoacetyl-L-Thyroxine Affinity-Labeled 55-Kilodalton Protein as Protein Disulfide Isomerase in Cultured Glial Cells (1991)

In glial cells, thyroid hormone regulates the polymerization state of the actin cytoskeleton by a mechanism that does not require protein synthesis or the nuclear T3 receptor. Using the affinity label N-bromoacetyl-L-T4, we identified a thyroid hormone-binding protein of 55 kDa (glial-p55) in cultured glial cells that is unique from the type II iodothyronine 5'-deiodinase and which exhibits a T4-dependent shift from a membrane-associated pool to the F-actin cytoskeleton. In a number of other cell types, a 55-kDa thyroid hormone-binding protein has been identified and shown to be a subunit of the enzyme protein disulfide isomerase (PDI). In this study we have characterized glial-p55 and compared it with purified rat hepatic PDI. Glial-p55 appears to be identical to PDI by peptide fragmentation analysis, using multiple methods. The hydrodynamic properties of glial-p55, determined by molecular sieve chromatography and sucrose density centrifugation, showed that this protein has a native molecular mass of 115 kDa, which is in close agreement with that reported for PDI. Like PDI, glial-p55 is an acidic protein with a pI of 4.8 or less. Thus, the 55-kDa thyroid hormone-binding protein in glial cells appears to be PDI.
Artificial trans-Acting siRNAs Confer Consistent and Effective Gene Silencing (2008)

Manipulating gene expression is critical to exploring gene function and a useful tool for altering commercial traits. Techniques such as hairpin-based RNA interference, virus-induced gene silencing, and artificial microRNAs take advantage of endogenous posttranscriptional gene silencing pathways to block translation of designated transcripts. Here we present a novel gene silencing method utilizing artificial trans-acting small interfering RNAs in Arabidopsis (Arabidopsis thaliana). Replacing the endogenous small interfering RNAs encoded in the TAS1c gene with sequences from the FAD2 gene silenced FAD2 activity to levels comparable to the fad2-1 null allele in nearly all transgenic events. Interestingly, exchanging the endogenous miR173 target sequence in TAS1c with an miR167 target sequence led to variable, inefficient silencing of FAD2, suggesting a specific requirement for the miR173 trigger for production of small interfering RNAs from the TAS1c locus.
Singer-Dependent Falsetto Detection for Live Vocal Processing Based on Support Vector Classification (2006)

We present and analyze a machine learning technique to determine from an input sung vocal waveform if falsetto (also known as the head voice) is being used. Such a system may be used to tune signal processing parameters, ideally in real-time, for such applications as intelligibility enhancement of high-pitched sung notes, and other musical systems which tune signal processing parameters according to detected performance parameters. Our falsetto detector uses a support vector classifier trained on mel-frequency cepstral coefficients (MFCCs) computed from a newly collected database of anechoic sung notes. It is shown to give correct classification with better than 95% accuracy.
Limit on the diffuse flux of ultrahigh energy tau neutrinos with the surface detector of the Pierre Auger Observatory (2009)

Data collected at the Pierre Auger Observatory are used to establish an upper limit on the diffuse flux of tau neutrinos in the cosmic radiation. Earth-skimming ${\ensuremath{\nu}}_{\ensuremath{\tau}}$ may interact in the Earth's crust and produce a $\ensuremath{\tau}$ lepton by means of charged-current interactions. The $\ensuremath{\tau}$ lepton may emerge from the Earth and decay in the atmosphere to produce a nearly horizontal shower with a typical signature, a persistent electromagnetic component even at very large atmospheric depths. The search procedure to select events induced by $\ensuremath{\tau}$ decays against the background of normal showers induced by cosmic rays is described. The method used to compute the exposure for a detector continuously growing with time is detailed. Systematic uncertainties in the exposure from the detector, the analysis, and the involved physics are discussed. No $\ensuremath{\tau}$ neutrino candidates have been found. For neutrinos in the energy range $2\ifmmode\times\else\texttimes\fi{}{10}^{17}\text{ }\text{ }\mathrm{eV}&lt;{E}_{\ensuremath{\nu}}&lt;2\ifmmode\times\else\texttimes\fi{}{10}^{19}\text{ }\text{ }\mathrm{eV}$, assuming a diffuse spectrum of the form ${E}_{\ensuremath{\nu}}^{\ensuremath{-}2}$, data collected between 1 January 2004 and 30 April 2008 yield a 90% confidence-level upper limit of ${E}_{\ensuremath{\nu}}^{2}d{N}_{{\ensuremath{\nu}}_{\ensuremath{\tau}}}/d{E}_{\ensuremath{\nu}}&lt;9\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}8}\text{ }\text{ }\mathrm{GeV}\text{ }\text{ }{\mathrm{cm}}^{\ensuremath{-}2}\text{ }{\mathrm{s}}^{\ensuremath{-}1}\text{ }\text{ }{\mathrm{sr}}^{\ensuremath{-}1}$.
Analysis of Commercial Unsaturated Polyester Repair Resins (2009)

Abstract : The basic rheological, thermal, and mechanical properties of commercially available repair putties have been determined in this study, as has the composition of these products. These products contain 33% to 40% unsaturated polyester resin, 10% to 20% styrene, and 45% to 57% inorganic fillers. The fillers are made up of hollow glass microspheres, talc, magnesium carbonate, calcium carbonate, fumed silica, glass fibers, and various other minerals. These products have a glass transition temperature of roughly 25-deg C and a room temperature storage modulus of 2 to 4.6 GPa. These putties display shear thinning behavior as a result of the fillers. All of these properties provide important benchmark characteristics that must be more or less met by U.S. Army Research Laboratory/Drexel-invented environmentally friendly, hazardous air pollutant?free repair resins utilizing renewable fatty acid-based monomers.
In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth (2010)

A method is proposed to measure transverse blood flow by using photoacoustic Doppler broadening of bandwidth. By measuring bovine blood flowing through a plastic tube, the linear dependence of the broadening on the flow speed was validated. The blood flow of the microvasculature in a mouse ear and a chicken embryo (stage 16) was also studied.
Supplementary Figure Legends 1-5 from MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias (2023)

&lt;p&gt;PDF file - 57K&lt;/p&gt;
Reduction of linoleic acid inhibition in production of conjugated linoleic acid by <i>Propionibacterium freudenreichii</i> ssp. <i>shermanii</i> (2001)

A method for the production of conjugated linoleic acid (CLA) from linoleic acid (LA) using growing cultures of Propionibacterium freudenreichii ssp. shermanii JS was developed. The growth inhibitory effect of LA was eliminated by dispersing it in a sufficient concentration of polyoxyethylene sorbitan monooleate detergent. For the whey permeate medium used, the optimum LA:detergent ratio was 1:15 (w/w). As a result, the cultures tolerated at least 1000 microg x mL(-1) LA, which was converted to CLA with 57%-87% efficiency. The cis-9, trans-11 and trans-9, cis-11 isomers constituted 85%-90% of the CLA produced. The feasibility of the method was demonstrated also in de Man Rogosa-Sharpe (MRS) broth.
A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome (2018)

Following the publication of the above article, the authors noted an error in Figure 4, panel B. The colours of the localized and mCRPC samples were accidentally switched. The authors have corrected the colour scheme and added a key to the figure. They have also updated the colour scheme of panel C, both bars are now red instead of one red and one blue. The authors wish to apologize for any inconvenience caused.
A Quantitative Composite Scoring Tool for Orthopaedic Residency Screening and Selection (2006)

The ability to accurately screen and select orthopaedic resident applicants with eventual successful outcomes has been historically difficult. Many preresidency selection variables are subjective in nature and a more standardized objective scoring method seems desirable. A quantitative composite scoring tool (QCST) to be used in a standardized manner to help predict orthopaedic residency performance from application materials was developed. In 64 orthopaedic residents, four predictors (United States Medical Licensing Examination [USMLE] Part I scores, Alpha Omega Alpha status, junior year clinical clerkship honors grades, and the QCST score) were analyzed with respect to four residency outcomes assessments. The outcomes included three standardized assessments, the orthopaedic in-training examination scores (OITE), the American Board of Orthopaedic Surgery (ABOS) written and oral examinations, and an internal outcomes assessment, attainment of satisfactory chief resident associate (CRA) status. Collectively, the QCST score had the strongest association as a predictor for all three standardized outcomes assessments (p < 0.001). Honors grades during junior years clinical clerkships was most strongly associated with satisfactory CRA status (p < 0.001). A composite scoring tool that is an effective predictor of orthopaedic resident outcomes can be developed. Additional work is still required to refine this scoring tool for orthopaedic residency screening and selection.
Morphological changes of poly(ethylene terephthalate‐co‐isophthalate) during solid state polymerization (2011)

Abstract Poly(ethylene terephthalate‐ co ‐isophthalate) (PETI) prepolymer was submitted to solid state polymerization (SSP) at 184–230°C in a fixed bed reactor, to study the evolution of morphological changes during the process. Short reaction times were selected to investigate crystallization phenomena during nonisothermal (heating) and isothermal SSP phases. More specifically, multiple PETI melting behavior was observed and attributed to secondary crystallization, the rate of which increased significantly with SSP temperature. Reaction time was also found to exert a positive effect on solid‐phase perfection of secondary crystals, leading at each temperature to melting points close to the value of bottle‐grade poly(ethylene terephthalate). Finally, the mass fraction crystallinity of the SSP grades was found to comply with the crystal morphology encountered. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Magnetostriction of field-structured magnetoelastomers. (2005)

Field-structured magnetic particle composites are an important new class of materials that have great potential as both sensors and actuators. These materials are synthesized by suspending magnetic particles in a polymeric resin and subjecting these to magnetic fields while the resin polymerizes. If a simple uniaxial magnetic field is used, the particles will form chains, yielding composites whose magnetic susceptibility is enhanced along a single direction. A biaxial magnetic field, comprised of two orthogonal ac fields, forms particle sheets, yielding composites whose magnetic susceptibility is enhanced along two principal directions. A balanced triaxial magnetic field can be used to enhance the susceptibility in all directions, and biased heterodyned triaxial magnetic fields are especially effective for producing composites with a greatly enhanced susceptibility along a single axis. Magnetostriction is quadratic in the susceptibility, so increasing the composite susceptibility is important to developing actuators that function well at modest fields. To investigate magnetostriction in these field-structured composites we have constructed a sensitive, constant-stress apparatus capable of 1 ppm strain resolution. The sample geometry is designed to minimize demagnetizing field effects. With this apparatus we have demonstrated field-structured composites with nearly 10,000 ppm strain.