gebhart/patrepeval huggingface dataset:
A 29-MRNA HOST RESPONSE WHOLE-BLOOD SIGNATURE IMPROVES PREDICTION OF 28-DAY MORTALITY AND 7-DAY INTENSIVE CARE UNIT CARE IN ADULTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH SUSPECTED ACUTE INFECTION AND/OR SEPSIS (2022)

Background: Risk stratification of emergency department patients with suspected acute infections and/or suspected sepsis remains challenging. We prospectively validated a 29-messenger RNA host response classifier for predicting severity in these patients. Methods: We enrolled adults presenting with suspected acute infections and at least one vital sign abnormality to six emergency departments in Greece. Twenty-nine target host RNAs were quantified on NanoString nCounter and analyzed with the Inflammatix Severity 2 (IMX-SEV-2) classifier to determine risk scores as low, moderate, and high severity. Performance of IMX-SEV-2 for prediction of 28-day mortality was compared with that of lactate, procalcitonin, and quick sequential organ failure assessment (qSOFA). Results: A total of 397 individuals were enrolled; 38 individuals (9.6%) died within 28 days. Inflammatix Severity 2 classifier predicted 28-day mortality with an area under the receiver operator characteristics curve of 0.82 (95% confidence interval [CI], 0.74-0.90) compared with lactate, 0.66 (95% CI, 0.54-0.77); procalcitonin, 0.67 (95% CI, 0.57-0.78); and qSOFA, 0.81 (95% CI, 0.72-0.89). Combining qSOFA with IMX-SEV-2 improved prognostic accuracy from 0.81 to 0.89 (95% CI, 0.82-0.96). The high-severity (rule-in) interpretation band of IMX-SEV-2 demonstrated 96.9% specificity for predicting 28-day mortality, whereas the low-severity (rule-out) band had a sensitivity of 78.9%. Similarly, IMX-SEV-2 alone accurately predicted the need for day-7 intensive care unit care and further boosted overall accuracy when combined with qSOFA. Conclusions: Inflammatix Severity 2 classifier predicted 28-day mortality and 7-day intensive care unit care with high accuracy and boosted the accuracy of clinical scores when used in combination.
ChemInform Abstract: HALOGENATION OF C16 MACROLIDE ANTIBIOTICS. 17‐HALOLEUCOMYCINS (A3) (1976)

Abstract Während d2 s aus Leucomycin A3 und Pyrrolidin/Benzol in Gegenwart eines Molekularsiebes mit 92%iger Ausbeute gut erhältliche Enamin (I) mit Perchlorylfluorid nur das Difluormakrolid (IIa) und dessen Pyrrolidinium‐Derivat ergibt, wird mit N‐Chlor‐ bzw. N‐ Brom‐succinimid das Mono‐chlor‐ bzw. ‐brom‐makrolid (IIb) bzw. (IIc) erhalten.
Ptychographic hyperspectral spectromicroscopy with an extreme ultraviolet high harmonic comb (2016)

We demonstrate a new scheme of spectromicroscopy in the extreme ultraviolet (EUV) spectral range, where the spectral response of the sample at different wavelengths is imaged simultaneously. It is enabled by applying ptychographical information multiplexing (PIM) to a tabletop EUV source based on high harmonic generation, where four spectrally narrow harmonics near 30 nm form a spectral comb structure. Extending PIM from previously demonstrated visible wavelengths to the EUV/X-ray wavelengths promises much higher spatial resolution and more powerful spectral contrast mechanism, making PIM an attractive spectromicroscopy method in both the microscopy and the spectroscopy aspects. Besides the sample, the multicolor EUV beam is also imaged in situ, making our method a powerful beam characterization technique. No hardware is used to separate or narrow down the wavelengths, leading to efficient use of the EUV radiation.
On tuning the microarchitecture of an HPS implementation of the VAX (1987)

The HPS Microarchitecture has been developed as an execution model for implementing various architectures at very high performance. A considerable amount of effort has gone into the use of HPS as a microarchitecture for the VAX. In this paper, we describe our first full simulation of the microVAX subset, and report the results of varying (i.e. tuning) certain important parameters.
Ontology-Based Multidimensional Personalization Modeling for the Automatic Generation of Mashups in Next-Generation Portals (2008)

Recently, the combination of portal and mashup technology has gained some attention. Portals were originally designed as single points of access to the information and applications distributed across the enterprise. However, due to the increasing number of resources available through portals, they have gained a new challenging goal: To provide users with the information tailored to their individual needs and geared to the situation they are working in. Mashups, the tools that dynamically integrate independent applications, seem to be a good technique to achieve this goal. What is needed, however, are means to automatically create personalized mashups that optimally fit a user's information needs in a given situation. In this paper, we describe our approach to this automatic mashup generation. At the core of our approach are different ontology-based models that describe the user, the domain, possible information needs in this domain, and personalization rules determining which information to present to which user in which situation.
Accurate Tunable-Gain 1/&amp;lt;i&amp;gt;x&amp;lt;/i&amp;gt; Circuit Using Capacitor Charging Scheme (2015)

This paper proposes an accurate tunable-gain 1/x circuit. The output voltage of the 1/x circuit is generated by using a capacitor charging time that is inversely proportional to the input voltage. The output voltage is independent of the process parameters, because the output voltage depends on the ratios of the capacitors, resistors, and current mirrors. The voltage gain of the 1/x circuit is tuned by a 10-bit digital code. The 1/x circuit was fabricated using a 0.18 m CMOS process. Its core area is 0.011 mm 2 (144 m 78 m), and it consumes 278 W at V DD = 1.8 V and f CLK = 1 MHz. Its error is within 1.7% at V IN = 0.05 V to 1 V.
Joint space-time clutter and inteference covariance estimation for non-chirped radar (2005)

We investigate the problem of clutter covariance estimation from multichannel radar data with non-specific waveforms. This differs from other similar algorithms in that they are typically tailored for a specific transmitted waveform, in most cases an LFM chirp. We also consider the possibility that there is interference, within the data, caused by a spatially localized source that is independent of the transmitted signal. We frame the problem of estimating the space-time covariance matrices of both the clutter and interference separately as one of maximum-likelihood estimation, and obtain a solution via the expectation-maximization algorithm. Results with simulated data are presented.
General partial properties (2009)

Abstract Partial molar properties are useful thermodynamic properties because their molar average equals the property itself. In this article, we present a description of partial properties in general, and we show that for many partial properties, partial molar properties being a subset, the property is a molar average of the partial properties. Although partial molar properties remain the most useful, several of the other partial properties could have practical applications. © 2009 American Institute of Chemical Engineers AIChE J, 2009
An Efficient Bioinformatics Processing Scheme using AHP Algorithm in Big Data Environment (2016)

Background/Objectives: Bioinformatic information in many diverse areas is being collected, managed, and stored in relation to the genome project. However, studies related to bioinformatics until now has very low efficiency due to improper management of the bioinformatic information. Methods/Statistical Analysis: In this paper, a data processing scheme applying the AHP algorithm is proposed for efficient management of bioinformatic information. The proposed scheme improves information accuracy by assigning property weights by hierarchically classifying the property information (type, property, priority, etc). Findings: Furthermore, the proposed scheme interconnects weighted bioinformatic information according to the weight to minimize the process time between the server and user, thereby improving the information accessibility. Application/Improvements: As a result of performance evaluation, the proposed scheme obtained improved results compared to the conventional schemes in terms of throughput and process time between the LSS (Location Service Server) and user.Keywords: AHP, Algorithm, Big Data, Bioinformatics, Data Process
Basic performance of the PET scanner, EXACT HR/sup +/, with adjustable data-acquisition parameters (1999)

The sensitivity and the spatial resolution of the ECAT EXACT HR/sup +/, a 3D PET scanner from Siemens/CTI, were analyzed with reference to adjustable data acquisition parameters. The standard protocol of the National Electrical Manufacturers Association (NEMA) was followed with a minor modification. The performance was shown to depend on the parameters prominently in the 3D mode. The advantages and disadvantages of altering the parameters were discussed. It was concluded that the data acquisition parameters should be carefully selected for a specific clinical situation in order to maximize the efficiency of PET measurement.
Reactor Evaluation of Ceria-Zirconia as an Oxygen Storage Material for Automotive Catalysts (1997)

&lt;div class="htmlview paragraph"&gt;We have prepared and tested laboratory scale monoliths wash-coated with 10, 20 and 30 wt% of either CeO&lt;sub&gt;2&lt;/sub&gt; or Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; (remainder is alumina). Wet impregnation was used to load the wash-coated monoliths with 50g/ft Pt:Rh at a 5:1 ratio. The catalyst were aged at temperatures between 825°C and 950°C using a cycled redox aging. The catalysts were then tested in a full-feed simulated exhaust laboratory reactor with air-to-fuel ratio (A/F) perturbations (frequencies at 1 and 3 Hz and amplitudes up to +/- 0.8 A/F). Even the lowest loading of Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; outperformed all three loadings of CeO&lt;sub&gt;2&lt;/sub&gt; over a full range of reaction temperatures, A/F perturbations, and catalyst space velocity (SV). Our data indicates that the ceria-zirconia catalysts can tolerate cycled redox aging at sustained bed temperatures at least 25°C higher (∼925°C vs. &amp;lt; 900°C) than can ceria. For the CeO&lt;sub&gt;2&lt;/sub&gt; catalysts aged at or above 900°C we observed an inverse correlation of catalyst activity to CeO&lt;sub&gt;2&lt;/sub&gt; loading. Using activity measurements, we attributed this inverse correlation to excessive sintering of the precious metals (PM) in the highly CeO&lt;sub&gt;2&lt;/sub&gt; loaded parts. For the Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; catalysts we found the performance to be insensitive to catalysts aging up to aging temperature of 925°C (for 8 hours). For the Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; catalysts we found the performance to be independent of Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; loading between 10 and 30wt%. Reactor measurements of OSC show that increasing the Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; loading was not increasing OSC in the aged parts even though the higher loaded fresh catalysts had higher OSC. Taken together our data suggest that poor PM distribution to the Ce&lt;sub&gt;.75&lt;/sub&gt;Zr&lt;sub&gt;.25&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; resulted in an “under-promotion” of this oxygen storage materials.&lt;/div&gt;
Quorum Sensing in Chromobacterium violaceum: DNA Recognition and Gene Regulation by the CviR Receptor (2011)

The bacterial pathogen Chromobacterium violaceum uses a LuxIR-type quorum-sensing system to detect and respond to changes in cell population density. CviI synthesizes the autoinducer C(10)-homoserine lactone (C(10)-HSL), and CviR is a cytoplasmic DNA binding transcription factor that activates gene expression following binding to C(10)-HSL. A number of behaviors are controlled by quorum sensing in C. violaceum. However, few genes have been shown to be directly controlled by CviR, in part because the DNA motif bound by CviR is not well characterized. Here, we define the DNA sequence required for promoter recognition by CviR. Using in vivo data generated from a library of point mutations in a CviR-regulated promoter, we find that CviR binds to a palindrome with the ideal sequence CTGNCCNNNNGGNCAG. We constructed a position weight matrix using these in vivo data and scanned the C. violaceum genome to predict CviR binding sites. We measured direct activation of the identified promoters by CviR and found that CviR controls the expression of the promoter for a chitinase, a type VI secretion-related gene, a transcriptional regulator gene, a guanine deaminase gene, and cviI. Indeed, regulation of cviI expression by CviR generates a canonical quorum-sensing positive-feedback loop.
Preliminary Observations on the Role of the Sympathetic Nervous System in Development and Maintenance of Experimental Renal Hypertension. (1966)

SummaryThe influence of the sympathetic nervous system upon the course of experimental renal hypertension was examined in normal and immunologically sympathec-tomized rats. Blood pressures were recorded directly in the unanesthetized animal through indwelling catheters in the abdominal aorta. Immunological sympathectomy did not prevent the development of the acute phase of renal hypertension. Blood pressures of the hypertensive sympathectomized animals returned to normotensive levels 4-5 weeks following renal artery clamping, while untreated animals remained hypertensive at the termination of the experiment. It was concluded that the sympathetic nervous system is not required for development of renal hypertension, but may play a role in maintaining the chronic phase of the hypertensive state.
THE LATEST ADVANCES IN HIGH-DIELECTRIC THIN-FILM CAPACITOR TECHNOLOGY FOR GHz-RF DEVICES (2005)

ABSTRACT We present parallel-plate (Ba,Sr)TiO3 and SrTiO3 thin-film capacitor technology on silicon for RF devices. The in-plane thermal stress that is critical to low expansive Si substrates can be controlled by tuning the sputtering deposition pressure, and a corresponding change in the permittivity due to the electrostrictive effect is observed. The high-frequency dielectric response analysis combined with the equivalent circuit model and electromagnetic simulation enables accurate estimation of the intrinsic dielectric properties, thus demonstrating the linear increase of dielectric loss with frequency. With the bias applied, an electromechanical resonance appears in the GHz band due to piezoelectric effect, which is reproduced using the finite element method.
Telomere biology in Metazoa (2010)

In this review we present critical overview of some of the available literature on the fundamental biology of telomeres and telomerase in Metazoan. With the exception of Nematodes and Arthropods, the (TTAGGG)(n) sequence is conserved in most Metazoa. Available data show that telomerase-based end maintenance is a very ancient mechanism in unicellular and multicellular organisms. In invertebrates, fish, amphibian, and reptiles persistent telomerase activity in somatic tissues might allow the maintenance of the extensive regenerative potentials of these species. Telomerase repression among birds and many mammals suggests that, as humans, they may use replicative aging as a tumor protection mechanism.
Link Adaptation Strategies for Multi-Antenna Assisted WiMAX-like System (2007)

In this work, we have studied bit and power allocation strategies for multi-antenna assisted Orthogonal Frequency Division Multiplexing (OFDM) systems. Popularly it is believed that simultaneous bit and power allocation at the same rate is not very much useful in terms of system throughput. Contrary to this popular belief, we have found that in some scenarios and in some system conditions, bit and power allocations across OFDM sub-channels are required together for efficient system performance. We have studied a novel link adaptation algorithm in different multi-antenna systems. We have found that, if we cannot find the exact Signal to Noise Ratio (SNR) thresholds due to different reasons, such as reduced Link Adaptation (LA) rate, Channel State Information (CSI) error, feedback delay etc., it is better to fix the transmit power across all sub-channels to guarantee the target Frame Error Rate (FER). Otherwise, we can use adaptive power distribution to save power, which can be used for other purposes.
MSE BOUNDS DOMINATING THE CRAM (2005)

TraditionalCram´ er-Rao typebounds provide benchmarks onthevariance of any estimator of a deterministic parameter vector, while requiring a priori specification of a desired bias gradient. However, in applications, it is often not clear how to choose the required bias. A direct measure of the estimation error that takes both the variance and the bias into account is the mean-squared error (MSE). Here, we develop bounds on the MSE in estimating a deterministic vector x0 using estimators with linear bias vectors, which includes the traditional unbiased estimation as a special case. We show that there often exists linear bias vectors that result in an MSE bound that dominates the CRLB, so that it is smaller than the CRLB for all x0. Furthermore, we explicitly construct estimators that achieve these bounds by linearly transforming the maximum-likelihood estimator.
Antigens Associated with Human Solid Tumors (1980)

The detection and diagnosis of cancer is dependent upon the ability to discriminate between normal and neoplastic tissues. At present, this determination relies upon the recognition of abnormal morphologic features associated with neoplasia. The utilization of specific biochemical differences between normal and neoplastic tissues in the development of highly sensitive assays might yield definitive methods for the early detection of tumors. Furthermore, specific biochemical differences may be exploited for preventive and/ or curative measures. These concepts, coupled with the recent advances in the field of immunochemical analysis, have made the search for tumor-specific antigens of great interest.
A 59GHz-to-67GHz 65nm-CMOS high efficiency Power Amplifier (2011)

A two-stage single-ended Power Amplifier (PA) is fabricated for the 60GHz Wireless Personal Area Network (WPAN) standard. It is based on the 65nm CMOS technology from STMicroelectronics. The PA is biased in class A and uses distributed elements to perform impedances matching. S-parameters and large signal simulations are validated by measurement results. Load pull measurements are performed to get the best operation of the PA. It achieves a saturated output power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> ) of 12dB and offers Power Added Efficiency (PAE) of 15%. The die area is 0.29mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with pads.
<title>Real-time facial action image synthesis system driven by speech and text</title> (1990)

Automatic facial motion image synthesis schemes and a real-time system design are presented. The purpose of this schemes is to realize an intelligent human-machine interface or intelligent communication system with talking head images. Human's face is reconstructed with 3D surface model and texture mapping technique on the display of terminal. Facial motion images are synthesized naturally by transformation of the lattice points on wire frames. Two types of motion drive methods, text to image conversion and speech to image conversion are proposed in this paper. In the former manner, synthesized head can speak some given texts naturally and in the latter case, some mouth and jaw motions can be synthesized in time to speech signal of behind speaker. These schemes were implemented to a parallel image computer and a real-time image synthesizer could output facial motion images to the display as fast as video rate.
Re-designing dynamic content delivery in the light of a virtualized infrastructure (2017)

We explore the opportunities and design options enabled by novel SDN and NFV technologies, by re-designing a dynamic content delivery network (CDN) service. Our system, named MOSTO, provides performance levels comparable to that of a regular CDN, but does not require the deployment of a large distributed infrastructure. In the process of designing the system, we identify relevant functions that could be integrated in the future Internet infrastructure. Such functions greatly simplify the design and effectiveness of services, such as MOSTO. We demonstrate our system using a mixture of simulation, emulation, testbed experiments, and by realizing a proof-of-concept deployment in a planet-wide commercial cloud system.
Postirradiation examination and evaluation of Fort St. Vrain fuel element 1-0743 (1981)

Fort St. Vrain (FSV) fuel element 1-0743 was irradiated in core location 17.04.F.06 from July 3, 1976 until February 1, 1979. The element experienced an average fast neutron exposure of about 0.95 x 10/sup 25/ n/m/sup 2/ (E > 29 fJ)/sub HTGR/, a time-and-volume-averaged fuel temperature in the vicinity of 680/sup 0/C, fissile and fertile particle burnups of approximately 6.2% and 0.3%, respectively, and a total burnup of 12,210 MWd/tonne. The postirradiation examination revealed that the element was in excellent condition. No cracks were observed on any of the element surfaces. The structural integrity of the fuel rods was good. No evidence of mechanical interaction between the fuel rods and fuel body was observed. Calculated irradiation parameters obtained with HTGR design codes were compared with measured data. Radial and axial power distributions, irradiation temperatures, neutron fluences, and fuel burnups were in good agreement with measurements. Calculated fuel rod strains were about a factor of three greater than were observed.
Annotating Needles in the Haystack without Looking (2015)

Business-to-consumer (B2C) emails are usually generated by filling structured user data (e.g.purchase, event) into templates. Extracting structured data from B2C emails allows users to track important information on various devices.
Identification of an Integration Center for Cross-talk between Protein Kinase C and G Protein Modulation of N-type Calcium Channels (1999)

The modulation of presynaptic calcium channel activity by second messengers provides a fine tuning mechanism for neurotransmitter release. In neurons, the activation of certain G protein-coupled receptors reduces N-type channel activity by approximately 60%. In contrast, activation of protein kinase C (PKC) results in an approximately 50% increase in N-type channel activity, and subsequent G protein inhibition is antagonized. Here, we describe the molecular determinants that control the dual effects of PKC-dependent phosphorylation. The double substitution of two adjacent PKC consensus sites in the calcium channel domain I-II linker (Thr422, Ser425) to alanines abolished both PKC-dependent up-regulation and the PKC-G protein cross-talk. The single substitution of Ser425 to glutamic acid abolished PKC up-regulation but had no effect on G protein modulation. Replacement of Thr422 with glutamic acid eliminated PKC-dependent up-regulation and mimicked the effects of PKC phosphorylation on G protein inhibition. Our data suggest that Thr422 mediates the antagonistic effect of PKC on G protein modulation, while phosphorylation of either Thr422 or Ser425 are sufficient to increase N-type channel activity. Thus, Thr422 serves as a molecular switch by which PKC is able to simultaneously trigger the up-regulation of channel activity and antagonize G protein inhibition.