gebhart/patrepeval huggingface dataset:
Treatment And Results Of Combined Mild Bone Loss Instability With The Modified Laterjet (2015)

Objectives: Recurrent anterior glenohumeral dislocation in the setting of an engaging Hill-Sachs lesion is high. The Latarjet procedure has been well-described for restoring glenohumeral stability in patients with over 25% glenoid bone loss. However, the treatment for patients with combined humeral head and mild (&lt;25%) glenoid bone loss remains unclear. We report on the outcomes of the modified Latarjet for this population. Methods: Modified Latarjet was performed in twenty three patients with recurrent anterior shoulder instability, engaging Hill-Sachs by exam confirmed with arthroscopy, and less than 25% anterior glenoid bone loss. The mean follow-up was 3.5 years. All patients were assessed for their risk of recurrence using the Instability Severity Index Score (ISIS), had pre-operative 3D imaging to assess humeral and glenoid bone loss. Single Assessment Numeric Evaluation (SANE), Western Ontario Shoulder Instability Index (WOSI), recurrence rate, radiographs, range of motion and dynamometer strength were used to assess outcomes. Results: Average pre-operative instability severity index score was 6.2 (range 4-9). Pre-operative glenoid bone loss averaged 15.1% (range 5-25%). The humeral defect averaged 40.4% in width and 13.7% in depth on axial computed tomography scan, with an average Hill-Sachs angle of 28°. The mean WOSI index was 457 of 2100 (range 0-1398). The mean SANE score was 81.2 (range 60-100). Five out of ten competitive athletes returned to play for at least one season. There were no recurrent dislocation and three patients had a single episode of recurrent subluxation. Loss of external rotation at the side averaged 8°, and there was no significant loss of abduction. Subscapularis, abduction and external rotation strength averaged greater than 85% of the contralateral shoulder. Fourteen patients on average had 1.4 (range 1-4) previous open or arthroscopic stabilization procedures prior to the Latarjet, nine others had Latarjet done primarily. WOSI scores correlated directly with number of previous surgery (r=0.81, p=0.02). Average WOSI score was 239 (range 0-510) in primary Latarjet, 495 (range 42-1024) in patients with one previous stabilization procedure, and 674 (range 192-1398) in patients with two or more previous stabilization procedures (ANOVA p&lt;0.001). There were three deep infections, two graft fractures, two painful hardware, one broken screw with graft malunion, and one radiographic graft nonunion. All infections, malunion and nonunion occurred in patients with failed previous stabilization procedures. No long-term nerve palsies were found. Resorption of the graft at the superior screw was seen in 28% of patients. Conclusion: The modified Latarjet is a reasonable choice for the treatment of an engaging Hill-Sachs lesion with concomitant mild anterior glenoid bone loss in this very demanding group of patients. However, the complication rate is significant.
methyvim: Targeted, robust, and model-free differential methylation analysis in R (2018)

<ns4:p> We present <ns4:italic>methyvim</ns4:italic> , an R package implementing an algorithm for the nonparametric estimation of the effects of exposures on DNA methylation at CpG sites throughout the genome, complete with straightforward statistical inference for such estimates. The approach leverages variable importance measures derived from statistical parameters arising in causal inference, defined in such a manner that they may be used to obtain targeted estimates of the relative importance of individual CpG sites with respect to a binary treatment assigned at the phenotype level, thereby providing a new approach to identifying differentially methylated positions. The procedure implemented is computationally efficient, incorporating a preliminary screening step to isolate a subset of sites for which there is cursory evidence of differential methylation as well as a unique multiple testing correction to control the False Discovery Rate with the same rigor as would be available if all sites were subjected to testing. This novel technique for analysis of differentially methylated positions provides an avenue for incorporating flexible state-of-the-art data-adaptive regression procedures (i.e., machine learning) into the estimation of differential methylation effects without the loss of interpretable statistical inference for the estimated quantity. </ns4:p>
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity (2022)

As there is a continuous need for novel anti-infectives, the present study aimed to fuse two modes of action into a novel 3-nitroimidazo[1,2-b]pyridazine scaffold to improve antiparasitic efficacy. For this purpose, we combined known structural elements of phosphodiesterase inhibitors, a target recently proposed for Trypanosoma brucei and Giardia lamblia, with a nitroimidazole scaffold to generate nitrosative stress. The compounds were evaluated in vitro against a panel of protozoal parasites, namely Giardia lamblia, Trypanosoma brucei, T. cruzi, Leishmania infantum and Plasmodium falciparum and for cytotoxicity on MRC-5 cells. Interestingly, selective sub-nanomolar activity was obtained against G. lamblia, and by testing several analogues with and without the nitro group, it was shown that the presence of a nitro group, but not PDE inhibition, is responsible for the low IC<sub>50</sub> values of these novel compounds. Adding the favourable drug-like properties (low molecular weight, cLogP (1.2-4.1) and low polar surface area), the key compounds from the 3-nitroimidazo[1,2-b]pyridazine series can be considered as valuable hits for further anti-giardiasis drug exploration and development.
A Study on the Relationship between Vehicle Behavior and Steering Wheel Torque on Steer by Wire Vehicles (2026)

It was reported that Steer-By-Wire (SBW) system, which eliminates driver interference, could introduce the active front steering control easier than that with a conventional steering system. But there have been few reports on studies about reactive torque control strategy for the steering wheel. This research on reactive torque control strategy was carried outin order to improve the driver usability and manoeuvrability of SBW system, it was found that the relation between what drivers feel by reactive torque when turning the steering wheel and what they feel from vehicle behavior could be improved by means of applying newly developed reactive torque that incorporates vehicle dynamics parameter.
Cytochrome P450 2C9 is Involved in Flow-Dependent Vasodilation of Peripheral Conduit Arteries in Healthy Subjects and in Patients with Chronic Heart Failure (2007)

FMD in human conductance arteries is reduced after inhibition of CYP 2C9, supporting the concept that CYP 2C metabolites contribute to endothelium-mediated vasodilation of peripheral conduit arteries in vivo. In patients with heart failure, the CYP-dependent FMD appears to be preserved.
Performance Verification and Monitoring of NC Machine-Tools for In-Process Part Measurement by Touch Probing (1997)

We present a methodology for the rapid diagnostic of a machine-tool using data acquired by touch probing. The probing may be performed either on existing portions of the machine such as the machine pallet, the part fixture or a brought in artefact depending on their geometry and accessibility. The method aims at providing frequent quick checks on the machine geometric health. An initial probing test provides a reference set of readings against which future probing tests are compared. The data is analysed to provide three levels of diagnostic. The first level concentrates on the resultant errors and pinpoints potentially faulty axes. The second level suggests potential causes in terms of axis parameters such as straightness, scale etc. Finally, the third level indicates how the part features to be machined or probed by the machine may be affected.
Urolithiasis, Endourology and Laparoscopy (2008)

No AccessJournal of UrologyAdult Urology1 Aug 2008Urolithiasis, Endourology and Laparoscopy Ralph ClaymanM.D. Ralph ClaymanRalph Clayman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.04.092AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Urolithiasis, Endourology and Laparoscopy." The Journal of Urology, 180(2), p. 673 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 180Issue 2August 2008Page: 673 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ralph Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Experimental study of perpendicular transport in weakly coupled AlxGa1−xN/GaN superlattices (2003)

Perpendicular transport characteristics of n-type AlxGa1−xN/GaN superlattices are presented. Planar and mesa-etched superlattice structures are employed to identify the perpendicular resistance. Perpendicular transport measurements in Al0.22Ga0.78N/GaN superlattices display linear current–voltage characteristics with a resistivity that is a factor of 6.6 higher than for bulk material. A theoretical model is developed for perpendicular transport in AlxGa1−xN/GaN superlattices based on sequential tunneling. The model shows that short superlattice periods are required to minimize the perpendicular resistivity.
IEC Breeder for D-3He Satellite Systems (1996)

D-3He fusion minimizes neutrons and maximizes charged fusion products, enabling increased energy recovery efficiency by direct conversion. However, scarce 3He terrestrial resources1 have deterred research & development (R&D) on this alternative. Here, we explore 3He production through inertial electrostatic confinement (IEC) breeders, which supply 3He to field-reversed configuration (FRC) satellite reactors.2 The breeder-satellite system is analyzed in terms of energy balance, taking the net energy gain of the overall system as the key parameter. An economic study determines the competitiveness of breeding with respect to 3He lunar mining, already shown to be an attractive route for commercial exploitation.3
How to capture benzyl radicals: the light, the peroxide and the heterocyclic trap (2010)

A photochemical benzylation of protonated heteroaromatic bases was realized by single electron transfer (SET) to the excited state of the base from the aromatic reactant. The benzylated product is formed by cross-coupling between the benzyl radical and the heterocyclic radical when they are in close proximity to one another. This allows the formation of products which are, to the best of our knowledge, unaccessible in other ways and which have now been obtained for the first time.
The effects of extrusion and enzyme addition in wheat based diets on fermentation in the large intestine and expression of swine dysentery (1997)

Diets containing soluble non-starch polysaccharides (NSP) and resistant starch (RS) have been shown to increase both hindgut fermentation and the incidence of swine dysentery (SD) (Pluske et al., 1996). The aim: of this study was to investigate the effects of extrusion (to reduceRS) and exogenous enzyme addition (to reduce soluble NSP) to a wheat based diet, on the extent of fermentation in the large intestine and on expression of SD.
Table S3 from Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma (2023)

&lt;p&gt;Summary of AntiDrug Antibody Data Incidence by Route of Administration&lt;/p&gt;
Vericiguat in patients with atrial fibrillation and heart failure with reduced ejection fraction: insights from the VICTORIA trial (2021)

Atrial fibrillation was present in nearly half of this high-risk population with worsening HF. A history of AF alone at baseline portends an increased risk of cardiovascular death. Neither type of AF affected the beneficial effect of vericiguat. Development of AF post-randomization was associated with an increase in both cardiovascular death and HF hospitalization which was not influenced by vericiguat.
Cellular and molecular engineering curriculum at Rice University (2002)

The tremendous advances in cellular and molecular biology over the last 25 years have fundamentally changed our understanding of living organisms. This new understanding at the level of cells and their array of associated molecules is having a tremendous impact on both medicine and technology. Appreciating the complexities of the cell and its inner workings will be crucial to turning our knowledge into effective treatment strategies at the tissue, organ and whole individual levels. With this in mind, the Bioengineering Department at Rice University is developing a curriculum that educates students in cellular and molecular processes and their control. In this talk, we will describe the structure of the Bioengineering undergraduate program at Rice University and the development of a series of new courses for the cellular and molecular engineering track. This series of courses starts with the basic concepts of engineering fundamentals at the sophomore level. This introductory course provides the foundation for the more advanced quantitative treatment of cell structure and function at the cellular and tissue levels taught in the junior and senior levels. We will discuss the development of three specific courses that cover topics ranging from molecular to tissue level. This sequence of courses exposes students to the cutting-edge synthesis of molecular and cellular information into design of tissue systems.
Nonlinearity enhancement and dispersion management in bismuth microstructured fibers with a filled slot defect (2008)

We investigate nonlinearity enhancement and dispersion management in microstructured fibers with a slotted-defect infiltrated with highly-nonlinear liquid. Using slot-defected-core bismuth microstructured fibers, gamma as high as 11,000 W-1km-1 and dispersion-flattened characteristics at telecom-band is possible.
<title>All-weather capability for rescue helicopters</title> (2001)

In Germany as well as in numerous other countries the air rescue system has been extended significantly since the first operation of the rescue helicopter Christoph 1. The primary target of the air rescue system was to guarantee fast and efficient emergency medical services for victims of accidents. During the years, the scope of the helicopter operations has been extended not only to other types of emergency medical services, but also to secondary medical services like the displacement of patients from hospitals to special service hospitals. While in general the displacement of patients is operated from well known and registered helipads, the primary rescue service currently has to rely on available onboard systems only. Those operations are risky and challenging for the pilots because of time pressure and the danger of obstacles in the environment of the helicopter. In addition, reduced visibility due to fog, rainfall or low light levels can further increase the risks or can make the services unavailable at all. Almost one decade ago, Eurocopter started the investigation of technologies and systems that could help the pilots to perform their tasks with reduced workload and risk, and to allow for a 24 h operation of helicopters irrespective of the weather conditions. After a number of preliminary studies, in 1995 the research program 'All-weather helicopter' has been started as a joint effort of Eurocopter and the supplier industry in Europe. The first phase of the program has been successfully completed in 1999 and the second phase is currently in progress.
Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts (2015)

Cardiac progenitor cells are multipotent and give rise to cardiac endothelium, smooth muscle, and cardiomyocytes. Here, we define and characterize the cardiomyoblast intermediate that is committed to the cardiomyocyte fate, and we characterize the niche signals that regulate commitment. Cardiomyoblasts express Hopx, which functions to coordinate local Bmp signals to inhibit the Wnt pathway, thus promoting cardiomyogenesis. Hopx integrates Bmp and Wnt signaling by physically interacting with activated Smads and repressing Wnt genes. The identification of the committed cardiomyoblast that retains proliferative potential will inform cardiac regenerative therapeutics. In addition, Bmp signals characterize adult stem cell niches in other tissues where Hopx-mediated inhibition of Wnt is likely to contribute to stem cell quiescence and to explain the role of Hopx as a tumor suppressor.
Output Voltage Control via Dynamic Cancellation of a GaN-Based High-Power-Density Single-Phase Transformer-Less Online UPS (2023)

This paper presents a dynamic cancellation control strategy for the inversion stage of the recently proposed high-power-density common-neutral single-dc-bus (CN-SDB) single-phase online uninterruptible power supply (UPS). The inversion stage operates in buck or buck-boost mode depending on the polarity of the output voltage reference and produces a sinusoidal output voltage. Owing to the dual-mode nature of the inversion stage, output voltage regulation with standard feedback control results in a large dc-offset and poor total harmonic distortion (THD), which is unacceptable for practical applications. To substantially improve the output voltage dc-offset and THD, a dynamic cancellation control strategy is proposed for the buck-boost mode of the dual-mode inversion stage. An analytical model capturing the dynamics of the inversion stage with dynamic cancellation control strategy is also presented to facilitate the controller design. A 1-kVA GaN-based prototype of online UPS is designed, built, and tested, and the output voltage THD is experimentally measured across a wide output voltage range. Standard feedback control strategy results in a 10% output voltage THD whereas the dynamic cancellation control strategy offers a significant improvement of 68% and results in a 3.2% output voltage THD.
Broadband Microwave AC Conductance Spectroscopy on Carbon Nanomaterials. (2015)

Abstract not provided.
Stereogenic-at-Iron Catalysts with a Chiral Tripodal Pentadentate Ligand (2021)

A class of stereogenic-at-iron catalysts is introduced and applied to asymmetric 3d-transition metal catalysis. The pentadentate coordination of a tripodal ligand creates a stereogenic iron center, while an isopropyl group in the ligand backbone serves as a chiral lever to thermodynamically favor one diastereomer (>20:1 dr) of the obtained iron complexes. The coordination sphere is completed with a labile acetonitrile ligand. Ligand coordination and dynamics were studied by NMR spectroscopy. A modular design of the tripodal ligand enables the convenient implementation of different modifications, which have been incorporated and investigated in this work. The catalytic performance of the obtained complexes was evaluated in the ring contraction of isoxazoles to chiral 2H-azirines in up to 99% yield and with up to 93% ee and features a remarkably high catalytic activity with up to 10,000 turnover numbers (TON).
An Optimized Mesh-Structured Switched-Capacitor Equalizer for Lithium-Ion Battery Strings (2018)

The existing switched-capacitor (SC)-based equalizers either have slow equalizing speed and low efficiency or have bulky volume and low reliability. Therefore, an optimized mesh-structured SC equalizer (MSSCE) is introduced to achieve a tradeoff between the equalization performances and size as well as cost. The proposed MSSCE achieves all the shortest balancing paths from one cell to any cell in a battery string, significantly improving the equalization speed and efficiency. The switching impedance of the proposed MSSCE is derived and analyzed, which provides design guidance for the switching frequency and the capacitance. A four-cell prototype was set up. Experimental results confirm that the proposed MSSCE enhances the balancing speed with a high efficiency of 91.7%, moreover which is robust to the imbalanced cell voltages.
Integrated Pharmacy Research and Practice (2012)

Adam Todd,1 Jonathan Ling21Wolfson Research Institute, School of Medicine and Health, Queen&amp;amp;rsquo;s Campus, Durham University, Stockton-on-Tees, UK; 2Faculty of Applied Sciences, University of Sunderland, Sunderland, UKBy 2014, the worldwide annual spend on medicines is expected to exceed one trillion dollars, representing an increase of nearly 90% since 2005.1 Thanks to modern medicine and the expanding number of pharmaceutical agents used to treat a wide range of diseases, average life expectancy is also set to increase, with, for example, average life expectancy in the UK increasing to 80 years of age, which is eight years higher than in the 1970s.2 However, despite this success, people around the world fail to use their medicines as they should, with a recent report by the World Health Organization estimating that, in developed countries, around 50% of patients are noncompliant with their long-term medication.3 In developing countries, this percentage is even higher, which is of particular concern because infectious diseases, such as human immunodeficiency virus and tuberculosis, are spreading rapidly. In view of this, the concept of &amp;amp;quot;pharmaceutical care&amp;amp;quot; has been introduced, and is defined as &amp;amp;quot;the responsible provision of drug therapy for the purpose of achieving definite outcomes that improve (or maintain) a patient&amp;amp;rsquo;s quality of life&amp;amp;quot;.4
Travel Time Prediction Algorithm Scalable to Freeway Networks with Many Nodes with Arbitrary Travel Routes (2005)

A travel time prediction algorithm scalable to large freeway networks with many nodes with arbitrary travel routes is proposed. Instead of constructing separate predictors for individual routes, it first predicts the whole future space–time field of travel times and then traverses the required subsection of the predicted travel time field to compute the travel time estimate for the requested route. Compared with the traditional approach that offers the same flexibility, the proposed method substantially reduces storage and computation time requirements at the relatively small computational cost at the time of actual prediction. It is first established that travel times computed by traversing travel time fields are compatible with more direct measurements of travel times from a vehicle reidentification technique based on electronic toll collection tags. This provides a conceptual justification of the proposed approach. When applied to the loop data from an 8.7-mi section of the I-80 freeway, the proposed approach with a time-varying coefficient (TVC) linear regression model as the component predictor not only improves the baseline historical travel time predictor substantially, with a 40% to 60% reduction in the prediction error, but also improves the traditional whole-route predictor based on the same TVC regression model by 6% to 9%. The result suggests that the proposed algorithm not only achieves the scalability but also improves prediction accuracy, both of which are critical for successful deployment of the advanced traveler information system for large freeway networks.