gebhart/patrepeval huggingface dataset:
Trust management for secure information flows (2008)

In both the commercial and defence sectors a compelling need is emerging for the rapid, yet secure, dissemination of information across traditional organisational boundaries. In this paper we present a novel trust management paradigm for securing pan-organisational information flows that aims to address the threat of information leakage. Our trust management system is built around an economic model and a trust-based encryption primitive wherein: (i) entities purchase a key from a Trust Authority (TA) which is bound to a voluntarily reported trust score r, (ii) information flows are encrypted such that a flow tagged with a recipient trust score R can be decrypted by the recipient only if it possesses the key corresponding to a voluntarily reported score r < = R, (iii) the economic model (the price of keys) is set such that a dishonest entity wishing to maximise information leakage is incentivised to report an honest trust score r to the TA. This paper makes two important contributions. First, we quantify fundamental tradeoffs on information flow rate, information leakage rate and error in estimating recipient trust score R. Second, we present a suite of encryption schemes that realise our trust-based encryption primitive and identify computation and communication tradeoffs between them.
One-way coupling enables noise-mediated spatiotemporal patterns in media of otherwise quiescent multistable elements (2006)

Recent work has demonstrated that undriven and overdamped bistable systems, which are normally quiescent, can oscillate if unidirectionally coupled into arrays with cyclic boundary conditions. Here, we understand such oscillations as corresponding to the propagation of solitonlike waves. Further, in large arrays, we demonstrate how noise and coupling, together, mediate the resulting complex spatiotemporal dynamics.
Plenary II: Energy-efficient and ultra low voltage design pf sub-14nm SoCs and microprocessors: Challenges and opportunities (2016)

This talk presents some of the prominent barriers to designing energy-efficient circuits in the sub-14nm CMOS technology regime and outlines new paradigm shifts necessary in next-generation multi-core microprocessors and systems-on-chip. Emerging trends and key challenges in sub-14nm design are outlined, including (i) device and on-chip interconnect technology projections, (ii) performance, leakage and voltage scalability, (iii) special-purpose hardware accelerators and reconfigurable co-processors for compute-intensive signal processing algorithms, (iv) fine-grain power management with integrated voltage regulators, and (v) resilient circuit design to enable robust variation-tolerant operation. Energy-efficient arithmetic and logic circuit techniques, static/dynamic supply scaling, on-die interconnect fabric circuits, ultra-low-voltage and near-threshold logic and memory circuit techniques, and multi-supply/multi-clock domain design for switching and leakage energy reduction are described. Special purpose hardware accelerators and data-path building blocks for enabling high GOPS/Watt on specialized DSP tasks such as encryption, graphics and media processing are presented. Power efficient optimization of microprocessors to span a wide operating range across high performance servers to ultra mobile SoCs, dynamic on-the fly configurability and adaptation, and circuit techniques for active/standby-mode leakage reduction with robust low-voltage operability are reviewed. Specific chip design examples and case studies supported by silicon measurements and trade-offs will be discussed.
A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor. (1993)

Elucidation of the three-dimensional structure of the complex of the epidermal growth factor (EGF) and its receptor is essential for understanding the molecular mechanisms of the EGF-receptor interaction and EGF-induced receptor-receptor interaction. NMR is useful to investigate interactions in solution between macromolecules at atomic resolution, but has a limitation in molecular masses of target proteins: less than 300 residues. We have prepared a fragment with apparent molecular mass of 40 kDa in SDS gels from the soluble extracellular domain of the EGF receptor (sEGFR, 619 residues) by sequential limited proteolysis with proteinase K and bromelain. This fragment is a monomeric structural domain consisting of 202 amino acid residues (Cys302-Arg503) and 18-kDa sugar chains, and binds EGF and transforming growth factor-alpha (TGF alpha). This 40-kDa domain has a dissociation constant of about 1 microM for human TGF alpha, which is similar to that of the parental sEGFR. sEGFR oligomerizes in response to EGF and TGF alpha, while the 40-kDa domain does not, suggesting that the sequences other than this domain is required for receptor oligomerization. The 40-kDa ligand-binding domain described in this report is suitable for analysis by various physico-chemical approaches such as NMR.
PS-BPB07-1: DEVELOPMENT OF ANTI-THROMBOTIC VACCINE AGAINST HUMAN S100A9 (2023)

Background &amp; Purposes: In post-stroke patients, a decreased adherence to antiplatelet drugs is a major challenge in the prevention of recurrent stroke. Previously, we have reported that a newly designed antiplatelet vaccine against S100A9 could prevent thrombosis in the middle cerebral artery in mice by inhibiting S100A9/CD36 signaling in platelets. However, the difference in amino acid sequences in epitopes between mice and humans might be problematic for clinical use. In the present study, we redesigned the S100A9 vaccine for the common sequence in both humans and monkeys and examined its effects in cynomolgus monkeys. Methods: First, we screened several candidate epitopes in mice and the selected epitope in human S100A9, which is common in monkey S100A9, was conjugated to Keyhole limpet hemocyanin. A mixture of the vaccine and Alum adjuvant was subcutaneously injected into 4 cynomolgus monkeys, three times every two weeks. Antibody production against human S100A9 was examined by ELISA or western blotting. Anti-thrombotic effects in collagen-induced thrombosis were examined in a mixture of vaccinated serum and fresh whole blood from another cynomolgus monkey using an automated microchip flow-chamber system. Bleeding time was evaluated in two monkeys. Results: Based on results of computed epitope prediction, we first assessed whether 2 to 11, 97–106, or 104–113 amino acids, where the amino acid sequence is approximately similar between humans and monkeys, could raise antibodies against S100A9 in mice. Compared with the vaccine for the 2–11 amino acids epitopes, 97–106 amino acids and 104–113 amino acids demonstrated higher antigenicity, indicating that epitopes in the C-terminus are stronger than those in the N-terminus. Based on this result, we selected 102 to 112 amino acids as the epitope for the human S100A9 vaccine. When the monkeys were vaccinated, antibody titers against human S100A9 were significantly increased. Western blotting analysis showed that the produced antibody recognized human S100A9. Although the addition of pre-vaccinated serum into fresh whole blood did not affect thrombus formation, post-vaccination serum inhibited collagen-induced thrombosis formation in two monkeys. Anti-thrombotic effects were partially inhibited by the epitope peptide, indicating the feasibility of neutralizing anti-thrombotic effects by vaccination. Notably, prolongation of bleeding time was not observed in vaccinated monkeys. Conclusions: Anti-human S100A9 vaccine revealed anti-thrombotic effects in some monkeys without affecting bleeding time. Although further studies are necessary to increase the effects and warrant the safety aspects, this vaccine could clarify the use of an anti-thrombotic vaccine in clinical settings.
Wide Area Thermal Processing of Light Emitting Materials (2011)

Laboratory laser materials synthesis of wide bandgap materials has been successfully used to create white light emitting materials (LEMs). This technology development has progressed to the exploration on design and construction of apparatus for wide area doping and phase transformation of wide bandgap material substrates. The objective of this proposal is to develop concepts for wide area doping and phase transformation based on AppliCote Associates, LLC laser technology and ORNL high density pulsed plasma arc technology.
A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BN®) in 56-80-Year-Old Subjects (2016)

ClinicalTrials.gov NCT00857493.
Conformer-dependent proton-transfer reactions of ubiquitin ions (1997)

The conformations of ubiquitin ions before and after being exposed to proton transfer reagents have been studied by using ion mobility/mass spectrometry techniques. Ions were produced by electrospray ionization and exposed to acetone, acetophenone, n-butylamine, and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene. Under the conditions employed, the +4 to +13 charge states were formed and a variety of conformations, which we have characterized as compact, partially folded, and elongated, have been observed. The low charge state ions have cross sections that are similar to those calculated for the crystal conformation. High charge states favor unfolded conformations. The ion mobility distributions recorded after ions have been exposed to each base show that the lowest charge state that is formed during proton-transfer reactions favors a compact conformation. More open conformations are observed for the higher charge states that remain after reaction. The results show that for a given charge state, the apparent gas-phase acidities of the different conformations are ordered as compact < partially folded < elongated.
Novel Inhibition of Porcine Pepsin by a Substituted Piperidine (2002)

Pepsin inhibition by 3-alkoxy-4-arylpiperidine (substituted piperidine; (3R,4R)-3-(4-bromobenzyloxy)-4-[4-(2-naphthalen-1-yl-2-oxo-ethoxy)phenyl]piperidine) has been studied using steady-state kinetic and pre-equilibrium binding methods. Data were compared with pepstatin A, a well known competitive inhibitor of pepsin. Steady-state analysis reveals that the substituted piperidine likewise behaves as a competitive inhibitor. Pre-equilibrium binding studies indicate that the substituted piperidine can displace a fluorescently labeled statine inhibitor from the enzyme active site. Simulation of the stopped-flow fluorescence transients provided estimates of the K(d) values of 1.4 +/- 0.2 microm and 39 +/- 2 nm for the piperidine and the fluorescently labeled statine, respectively. The effects of combinations of these two inhibitors resulted in a series of parallel lines when plotted by the method of Yonetani and Theorell (Yonetani, T., and Theorell, H. (1964) Arch. Biochem. Biophys. 106, 234-251), suggesting that the two inhibitors bind in a mutually exclusive fashion to pepsin. Fitting of the entire data set to the appropriate equation yielded an alpha factor of 8 +/- 1. The magnitude of this factor ( infinity > alpha > 1) can be explained by a conformational distinction between the enzyme species that bind each inhibitor. The effects of pH on the inhibition constants for pepstatin A and the substituted piperidine also suggest that the inhibitors bind to distinct conformational forms of the enzyme. No inhibition by the piperidine was observed at acidic pH, while pepstatin A inhibition is maximal at low pH values. Inhibition by the piperidine was maximal when a group with pK 4.8 +/- 0.2 was deprotonated and another group with pK 5.9 +/- 0.2 was protonated. Most likely these two groups are the catalytic aspartates with perturbed ionization properties as a result of a significant and unique conformational change. Taken together, these data suggest that the enzyme can readily interconvert between two conformers, one capable of binding substrate and pepstatin A and the other capable of binding the substituted piperidine.
Proliferation of MIELIKI a novel t(7;9) early pre-B acute lymphoblastic leukemia cell line is inhibited concomitantly by IL-4 and IL-7. (1995)

The present study describes a novel cell line, MIELIKI, established from bone marrow of a pediatric patient with B lineage acute lymphoblastic leukemia (ALL) at diagnosis. The MIELIKI cell line displays an early pre-B cell phenotype (CD10+, CD19+, CD20+, CD34-, Cmu-, sIg-) with rearrangements on both Ig heavy chain and k light chain alleles, and carries an unfrequent t(7;9) chromosomal translocation identical to the freshly isolated leukemic blasts. The proliferation of MIELIKI cells was abrogated by IL-4 and by IL-7, as measured by DNA replication and viable cell recovery. The effects of IL-4 and IL-7 were mediated, respectively, through the CDw124 and CDw127 IL-4 and IL-7 receptor components. Growth inhibition by IL-4 was not mediated by soluble factors released by MIELIKI cells in response to IL-4, suggesting the existence of an intrinsic negative signaling pathway. Finally, neither IL-4 nor IL-7 were found to induce maturation of MIELIKI into cells expressing cytoplasmic or surface membrane mu chain. The present cell line should constitute a useful model of t(7;9) early pre-B ALL and allow investigation of the relationship between IL-4 and IL-7 negative signaling in leukemic B cell ontogeny.
Brillouin and Raman scattering studies of single-crystal-texture polyethylene (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBrillouin and Raman scattering studies of single-crystal-texture polyethylenePaul J. Phillips, Y. T. Jang, Q. L. Liu, Chin Hsieu Wang, and John F. RaboltCite this: Macromolecules 1985, 18, 8, 1571–1576Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ma00150a008https://doi.org/10.1021/ma00150a008research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced model-based Fault Detection and Diagnosis for civil aircraft structural design optimization (2013)

International audience
Immunomodulatory Drugs (IMiDs&#8482;): A New Treatment Option for Myelodysplastic Syndromes (2006)

The IMiDs represent a new proprietary class of thalidomide analogues that possess greater potency and less toxicity than the parent compound. As a group, these agents share the pharmacologic property of modulating cellular response to ligand activation, the precise biologic effect of which is cell lineage and stimulant-dependent. Lenalidomide (CC-5013; Revlimid), a second generation IMiD, has shown significant erythropoietic activity in patients with lower risk MDS that have failed or are not candidates for recombinant erythropoietin treatment. Unlike cytokine therapy, lenalidomide suppresses select MDS clones and enhances erythropoietin receptor signaling to restore erythropoiesis. Activity is greatest in patients with interstitial deletions involving chromosome 5q31.1. A multicenter phase II study reported a 76 % overall transfusion response rate in transfusion-dependent patients with deletion 5q, with 67 % achieving transfusion independence after a median interval of 4.6 weeks of treatment. Cytogenetic responses were observed in 73% of patients with complete cytogenetic remission in 45% patients. Both transfusion response and cytogenetic response frequency were independent of karyotype complexity, raising excitement that this new treatment strategy might favorably alter the natural history of disease in higher risk patients with deletion 5q. Lenalidomide was approved by the U.S. Food and Drug Administration on December 27, 2005, for the treatment of IPSS Low and intermediate-1 risk MDS patients with del(5q) abnormality. A phase III Intergroup trial (ECOG 2905) will test the capacity to potentiate erythropoietin response by comparing response to lenalidomide monotherapy to the combination of darbepoetin and lenalidomide in non-deletion 5q MDS patients.
A Study of Minimum Classification Error (MCE) Linear Regression for Supervised Adaptation of MCE-Trained Continuous-Density Hidden Markov Models (2007)

In this paper, we present a formulation of minimum classification error linear regression (MCELR) for the adaptation of Gaussian mixture continuous-density hidden Markov model (CDHMM) parameters. Two optimization approaches, namely generalized probabilistic descent (GPD) and Quickprop are studied and compared for the optimization of the MCELR objective function. The effectiveness of the proposed MCELR technique is confirmed via a series of supervised speaker adaptation experiments on a task of continuous Putonghua (Mandarin Chinese) speech recognition
Complexation of Cd(SeCN)2with imidazolidine-2-thione and its derivatives: Solid state, solution NMR and anti-bacterial studies (2008)

Reactions of imidazolidine-2-thione (Imt), 1,3-diazinane-2-thione (Diaz) and 1,3-diazipane-2-thione (Diap) with Cd(SeCN) 2 in acetonitrile resulted in the formation of 2:1 tetrahedral complexes. Both solid state and solution NMR, confirm the exocyclic thione atom to be the donor in all cases. 113 Cd shielding tensors and anisotropies were calculated from the solid-state NMR spectra. Based on the solid NMR data, a distorted tetrahedral dispositions of ligands around cadmium is proposed for the Imt complex. However, when the Imt ligand is substituted with one or two R groups (where R=Me, Et or i -Pr) forming RImt or R 2 Imt, a five coordinate complex with polymeric structure [(RImt)Cd(SeCN) 2 ] ∞ or [(R 2 Imt)Cd(SeCN) 2 ] ∞ is observed. Antibacterial studies of some of the complexes were carried out.
ChemInform Abstract: Chiral Induction by Elimination‐Coupled Lithium—Ene Reaction: Synthesis of (+)‐(3R,4R)‐1,2‐Dihydromultifidene. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A thermally responsive polymer microvalve without mechanical parts photo-patterned in a parylene channel (2004)

A photoresist-like thermally responsive polymer has been formulated, surface micromachined and integrated into parylene microchannels to realize an inline valve. The polymer physically swells below its lower critical solution temperature and shrinks above it. Test showed a 2.5-fold polymer volume increase by changing water temperature from 25 to 10/spl deg/C. Repeated polymer swelling and shrinking were observed inside the channel with a system response time around 7 s. Pressure build-up measurements were used to demonstrate the functionality of the valve. Valve test results using DI water showed that the pressure upstream of the polymer plug increased from 15.3 to 20.3 psi with temperature change from 36/spl deg/C to 15/spl deg/C.
Open runtime platform (2002)

According to conventional wisdom, interfaces provide flexibility at the cost of performance. Most high-performance Java virtual machines today tightly integrate their core virtual machines with their just-in-time compilers and garbage collectors to get the best performance. The Open Runtime Platform (ORP) is unusual in that it reconciles high performance with the extensive use of well-defined interfaces between its components. ORP was developed to support experiments in dynamic compilation, garbage collection, synchronization, and other technologies. To achieve this, two key interfaces were designed: one for garbage collection and another for just-in-time compilation. This paper describes some interesting features of these interfaces and discusses lessons learned in their use. One lesson we learned was to selectively expose small but frequently accessed data structures in our interfaces; this improves performance while minimizing the number of interface crossings.
A traditional Chinese medicine compound (Jian Er) for presbycusis in a mouse model: Reduction of apoptosis and protection of cochlear sensorineural cells and hearing. (2018)

Age-related hearing loss (AHL) or presbycusis is steadily increasing due to the overall aging of the Chinese population. Traditional Chinese medicine (TCM) has long been used to prevent and treat deafness, but its effectiveness and mechanism of action are still uncertain. The present study tested a TCM preparation called "Jian Er" in a mouse model of prebycusis.
Photoinduced transient states of antiferromagnetic orderings in La1/3Sr2/3FeO3 and SrFeO3−δ thin films observed through time-resolved resonant soft x-ray scattering (2022)

Abstract The relationship between the magnetic interaction and photoinduced dynamics in antiferromagnetic perovskites is investigated in this study. In La 1/3 Sr 2/3 FeO 3 thin films, commensurate spin ordering is accompanied by charge disproportionation, whereas SrFeO 3− δ thin films show incommensurate helical antiferromagnetic spin ordering due to increased ferromagnetic coupling compared to La 1/3 Sr 2/3 FeO 3 . To understand the photoinduced spin dynamics in these materials, we investigate the spin ordering through time-resolved resonant soft x-ray scattering. In La 1/3 Sr 2/3 FeO 3 , ultrafast quenching of the magnetic ordering within 130 fs through a nonthermal process is observed, triggered by charge transfer between the Fe atoms. We compare this to the photoinduced dynamics of the helical magnetic ordering of SrFeO 3− δ . We find that the change in the magnetic coupling through optically induced charge transfer can offer an even more efficient channel for spin-order manipulation.
Supplementary Figure Legend from The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers (2023)

Supplementary Figure Legend from The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers
An Exploratory Study of Endorectal Magnetic Resonance Imaging and Spectroscopy of the Prostate as Preoperative Predictive Biomarkers of Biochemical Relapse After Radical Prostatectomy (2010)

Index lesion volume on magnetic resonance spectroscopic imaging and high grade magnetic resonance spectroscopic imaging voxels correlate with time to biochemical recurrence after radical prostatectomy even when adjusted for clinical data. Results suggest the preoperative predictive usefulness of endorectal magnetic resonance imaging/magnetic resonance spectroscopic imaging in patients considering radical prostatectomy.