gebhart/patrepeval huggingface dataset:
Study on the simulation model of water environment pollution in plain lake basin (2011)

For reasons of temporal and spatial changes and strong randomness etc, the quantitative simulation for water environment pollution in plain lake basin is a much difficult work all the time. Simulation model makers are required to comprehensively master, as well as synthesize many methods or techniques to describe the natural and social complex systems. In this paper, Lake Chao was taken for example, a system dynamics(SD)-based method was proposed to simulate the cause, distribution and movement of the water environment pollution. Results show that, system dynamics, based on the info-feedback structure and combination of qualitative analysis and quantitative calculation, have the ability to simulate water environment pollution in plain lake basin. It can provide an efficient policy-experiment platform for department appointed to manage the Lake Chao basin.
X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice (2018)

The aim of this study was to evaluate the feasibility of early stage imaging of acute lung inflammation in mice using grating-based X-ray dark-field imaging in vivo. Acute lung inflammation was induced in mice by orotracheal instillation of porcine pancreatic elastase. Control mice received orotracheal instillation of PBS. Mice were imaged immediately before and 1 day after the application of elastase or PBS to assess acute changes in pulmonary structure due to lung inflammation. Subsequently, 6 mice from each group were sacrificed and their lungs were lavaged and explanted for histological analysis. A further 7, 14 and 21 days later the remaining mice were imaged again. All images were acquired with a prototype grating-based small-animal scanner to generate dark-field and transmission radiographs. Lavage confirmed that mice in the experimental group had developed acute lung inflammation one day after administration of elastase. Acute lung inflammation was visible as a striking decrease in signal intensity of the pulmonary parenchyma on dark-field images at day 1. Quantitative analysis confirmed that dark-field signal intensity at day 1 was significantly lower than signal intensities measured at the remaining timepoints, confirming that acute lung inflammation can be depicted in vivo with dark-field radiography.
High-potency ligands for DREADD imaging and activation in rodents and monkeys (2019)

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated <sup>18</sup>F positron emission tomography (PET) DREADD radiotracer, [<sup>18</sup>F]JHU37107. We show that JHU37152 and JHU37160 exhibit high in vivo DREADD potency. [<sup>18</sup>F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping.
Fast direct solution of 3-D scattering problems via nonuniform grid-based matrix compression (2011)

A fast non-iterative algorithm for the solution of large 3-D acoustic scattering problems is presented. The proposed approach can be used in conjunction with the conventional boundary element discretization of the integral equations of acoustic scattering. The algorithm involves domain decomposition and uses the nonuniform grid (NG) approach for the initial compression of the interactions between each subdomain and the rest of the scatterer. These interactions, represented by the off-diagonal blocks of the boundary element method matrix, are then further compressed while constructing sets of interacting and local basis and testing functions. The compressed matrix is obtained by eliminating the local degrees of freedom through the Schur's complement-based technique procedure applied to the diagonal blocks. In the solution process, the interacting unknowns are first determined by solving the compressed system equations. Subsequently, the local degrees of freedom are determined for each subdomain. The proposed technique effectively reduces the oversampling typically needed when using low-order discretization techniques and provides significant computational savings.
Improved cyclic retention and high‐performance supercapacitive behavior of poly(diphenylamine‐co‐aniline)/phosphotungstic acid nanohybrid electrode (2020)

In this study, a simple and facile electrochemical deposition technique was employed to fabricate fluorine-doped tin oxide-based polydiphenylamine-polyaniline/phosphotungstic acid copolymer nanocomposite modified electrode (FTO/PDPA-PANI/PTA) for high-performance supercapacitors application. Crystalline and morphological structure and coating thickness of PDPA-PANI/PTA nanocomposite on FTO were characterized using X-ray diffraction, scanning electron microscope, and atomic force microscope. The fabricated nanohybrid electrode exhibits superior specific capacitance of 360 Fg−1 at 1 mA current density. The higher capacitive behavior and cyclic steadiness of FTO/PDPA-PANI/PTA modified electrode were achieved because of the presence of tungsten in the PDPA/PANI co-polymer nanonetworks provide efficient interaction which enhances the fast electron transfer progressions. Electrochemical impedance spectroscopic (EIS) studies ensure the capacitive behavior of the electrodeposited nanohybrid modified electrode with a characteristic EIS semicircle in the lower frequency region. Further, a superior specific capacitance with 82% excellent capacitance retention after 1000 cycles, recommends a practical application in supercapacitor device electrodes.
Acute Coronary Syndrome in an Intensive Care Unit of a Tertiary Referral Centre in Central Nepal: The Spectrum and Coronary Risk Factors. (2013)

Introduction: Acute coronary syndrome is the major leading cause for coronary care unit admission. Its spectrum comprises a variety of disorders including unstable angina, non ST elevation and ST elevation myocardial infarction. Methods: An observational study was designed to study the spectrum of acute coronary syndrome and associated coronary heart disease risk factors in subjects admitted in intensive care unit from August 2009 to September 2010. Details including coronary risk factors and the categories and outcomes of acute coronary syndrome were analyzed. Results: A total of 57 subjects were included in the study. The majority (63.1%) were males. The mean age was 64.54±13.8 years. Five (8.8%) patients were ≤45 years and 29 (50.88%) patients were ≥65 years. Majority of the patients were smokers (50.87%). The other major coronary heart disease risk factors were diabetes (43.85%), hypertension (36.87%), dyslipidemia (26.32%) and previous history of coronary heart disease (31.58%). Coronary heart disease figured prominently in the family history as well (26.32%). ST elevation myocardial infarction was the major category (42.11%) followed by non-ST elevation myocardial infarction and unstable angina (31.58% and 26.32% respectively). Myocardial infarction complicated with cardiogenic shock had very high mortality (83.33%). Conclusions: The ST elevation myocardial infarction was the major clinical form of acute coronary syndrome admitted in intensive care unit. Prevention should be targeted on modifiable risk factors such as the management of risk factors. In addition, the improvement in cardiology service with the establishment of CCU and cathlab might alter the mortality and morbidity in ACS management. Keywords: acute coronary syndrome; coronary risk factors; intensive care unit.
Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery (2012)

An MR-HIFU mild hyperthermia heating algorithm was developed, resulting in accurate and homogeneous heating within the targeted region in vitro and in vivo, which is suitable for applications in drug delivery.
3D Camera Calibration Using Gray Code Patterns (2008)

This paper presents a new calibration method that uses gray code patterns as a planar chart displayed on an LCD and is based on a parametrical algorithm for stereo cameras. It enables to get high accuracy with easy operation and is well suited for stereo cameras with zoom lenses.
ChemInform Abstract: Vinylic C—F Bond Activation with Low‐Valent Zirconocene: The Generation and Cross‐Coupling Reactions of 1‐Fluorovinylzirconocene. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Artificial Neural Network (ANN) Based Fast and Accurate Inductor Modeling and Design (2020)

This paper analyzes the potential of Artificial Neural Networks (ANNs) for the modeling and optimization of magnetic components and, specifically, inductors. After reviewing the basic properties of ANNs, several potential modeling and design workflows are presented. A hybrid method, which combines the accuracy of 3D Finite Element Method (FEM) and the low computational cost of ANNs, is selected and implemented. All relevant effects are considered (3D magnetic and thermal field patterns, detailed core loss data, winding proximity losses, coupled loss-thermal model, etc.) and the implemented model is extremely versatile (30 input and 40 output variables). The proposed ANN-based model can compute 50'000 designs per second with less than 3% deviation with respect to 3D FEM simulations. Finally, the inductor of a 2 kW DC-DC buck converter is optimized with the ANN-based workflow. From the Pareto fronts, a design is selected, measured, and successfully compared with the results obtained with the ANNs. The implementation (source code and data) of the proposed workflow is available under an open-source license.
D-94 Invited —In-Situ and Time Resolved Small-Angle X-ray Scattering (2010)

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The Schwarz-Christoffel Analytical Method Applied to Electric Machine Slot Shape Optimization (2007)

The Schwarz-Christoffel method is implemented in a Monte Carlo electric machine slot shape search algorithm attempting to maximize average torque under constrained flux density in a two-dimensional developed machine cross-section. A fixed slot current density is enforced, and the slot shape is varied over a twelve-variable search space. Rotor motion is simulated by changing the position of the machine air gap polygon's rotor vertices while maintaining both a simply-connected polygon and a 90deg shift between stator and rotor q-axis currents. Rotor force is calculated by integrating Maxwell's stress tensor along a closed path enclosing the rotor. A Monte Carlo search with 11,050 points is carried out and a minimum cost horizon curve is deduced from the data. A brief history and context for the Schwarz-Christoffel approach is given with a comparison to the finite element and boundary element methods.
Genetic analysis of a tetracycline resistance element from Clostridium difficile and its conjugal transfer to and from Bacillus subtilis (1990)

A tetracycline resistance (Tcr) determinant from Clostridium difficile strain 630 was cloned into the Escherichia coli plasmid vector pUC13. The resulting plasmid pPPM20, containing an insert of 3.4 kbp, was mapped and a 1.1 kbp SacI-HindIII fragment wholly within the Tcr gene was identified. Dot-blot hybridization studies with the 1.1 kbp fragment showed that the Tcr gene belonged to hybridization class M. Tcr could be transferred between C. difficile strains and to Bacillus subtilis at a frequency of 10(-7) per donor cell. The element could be returned from B. subtilis to C. difficile at a frequency of 10(-8) per donor cell. This is the first demonstration of C. difficile acting as a recipient in intergeneric crosses. DNA from C. difficile transconjugants digested with EcoRV always has two hybridizing fragments of 9.5 and 11.0 kbp when probed with pPPM20. DNA from B. subtilis transconjugants digested with EcoRV produced one hybridizing band of variable size when probed with pPPM20. The behaviour of the element was reminiscent of the conjugative transposons. Therefore we compared the element to the conjugative transposon Tn916. The HincII restriction maps of the two elements differed and no hybridization was detected to oligonucleotides directed to the ends of Tn916. However, the elements do have some sequence homology, detected by hybridization analysis.
The Start-up of Thermophilic Anaerobic Digestion of Municipal Solid Waste (2016)

Thermophilic anaerobic digestion of municipal solid wastes (MSW) was conducted for 6 weeks in a lab-scale semi-continuous digester for investigating the start-up operation of anaerobic digestion treating MSW. The feedstock was a mixture of simulated food waste, paper waste, and in some cases, cow manure. Organic loading rate (OLR) was adjusted 1.14 ～4.00 gVS/kg-sludge/day to biogas production. At the initial stage of thermophilic anaerobic digestion, pH value gradually increased from 8.2 to 8.3 on 17th day from start-up. Free-ammonia concentration in the digester also gradually increased from 361.6 to 412.5 ppm. On 17th day, inhibition of free-ammonia occurs, and biogas generation stopped. After gas generation stopped on day 17, pH and free-ammonia concentration were adjusted to the proper level by adding paper and deionized water. As a result, gas generation restarted on day 21. Then the amount of food waste charged in the digester was decreased and that of paper waste was increased to adjust the total amount of nitrogen invested in the digester. Afterwards, pH value was settled around 7.8, and a stable digestion was achieved till the end of experiment. Inhibition of free-ammonia could be suppressed by adjusting the amount of nitrogen invested in the digester.
Effect of biopsy on the MRI radiomics classification of benign lesions and luminal A cancers (2019)

Radiomic features extracted from magnetic resonance (MR) images have potential for diagnosis and prognosis of breast cancer. However, presentation of lesions on images may be affected by biopsy. Thirty-four nonsize features were extracted from 338 dynamic contrast-enhanced MR images of benign lesions and luminal A cancers (80 benign/34 luminal A prebiopsy; 46 benign/178 luminal A postbiopsy). Feature value distributions were compared by biopsy condition using the Kolmogorov-Smirnov test. Classification performance was assessed by biopsy condition in the task of distinguishing between lesion types using the area under the receiver operating characteristic curve (AUCROC) as performance metric. Superiority and equivalence testing of differences in AUCROC between biopsy conditions were conducted using Bonferroni-Holm-adjusted significance levels. Distributions for most nonsize features for each lesion type failed to show a statistically significant difference between biopsy conditions. Fourteen features outperformed random guessing in classification. Their differences in AUCROC by biopsy condition failed to reach statistical significance, but we were unable to prove equivalence using a margin of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>Δ</mml:mi> <mml:mi>AUCROC</mml:mi> <mml:mo>=</mml:mo> <mml:mo>±</mml:mo> <mml:mn>0.10</mml:mn></mml:mrow> </mml:math> . However, classification performance for lesions imaged either prebiopsy or postbiopsy appears to be similar when taking into account biopsy condition.
Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery (2020)

Abstract Transdermal delivery offers a patient‐friendly method of drug administration. An ideal formulation for transdermal drug delivery should have high potency to enhance skin permeation and low tendency to induce skin irritation. Ionic liquids (ILs) and deep eutectic solvents (DESs) have recently been proposed to serve as an excellent platform to enable transdermal delivery of various therapeutics including proteins and siRNA. In spite of their success, general safety‐efficacy behavior of ILs/DESs is not reported. Using safety and efficacy as two design criteria, a Fourier transform infrared (FTIR) spectroscopy study is conducted to compare the performance of 31 ammonium‐based ILs/DESs and 44 conventional chemical permeation enhancer (CPE) molecules. FTIR analysis of skin stratum corneum exposed to ILs/DESs and CPEs is performed to extract features indicative of their safety and efficacy. ILs/DESs, as a class, outperformed conventional CPEs in terms of both potency and safety. Analysis of ILs/DESs and CPEs based on Hansen solubility parameters indicates that ILs/DESs possess solubility parameters close to those of skin, which may explain their superiority over CPEs. These studies support ILs/DESs as promising materials for novel drug delivery systems.
Alpha Adrenergic Regulation of Celiac Blood Flow and Plasma Catecholamine Response During Acute Heat Stress in Fed Cockerels (1986)

Hubbard cockerels with chronically implanted electromagnetic blood flow probes on the celiac artery were used to establish a relationship between changes in postprandial celiac mean blood flow (MBF) and plasma catecholamines during a acute heat exposure. Five min after the elevation of ambient temperature from 25 to 37 C, there were concomitant reductions (P less than .05) in celiac MBF, norepinephrine (NE), and heart rate (HR). After 50 min of heat stress, rectal temperature (Tr), respiratory rate (RR), plasma epinephrine (E), and celiac vascular resistance (CVR) were significantly greater (P less than .05) than preheat stress thermoneutral control values. During the thermoneutral recovery period, all parameters returned to values comparable to preheat exposure control with the exception of NE, which tended (P less than .1) to remain lower. To determine the role of the sympathetic nervous system in regulating postprandial celiac MBF during acute heat exposure, chronically instrumented cockerels were infused with phenoxybenzamine, an alpha-adrenergic receptor-blocking agent. Alpha-receptor blockade attenuated both postprandial intestinal hyperemia under thermoneutral conditions as well as the heat-induced reduction of postprandial celiac MBF. The results of these studies implicate the sympathetic nervous system in the regulation of postprandial celiac MBF in heat-stressed cockerels and indicate a possible alpha-adrenergic-mediated mechanism involved in postprandial intestinal hyperemia.
P480The value of ICD electrograms for localization of foci originating from different locations within the left ventricle (2017)

associated with an increased risk of sudden cardiac death in patients without structural heart disease (SHD).We sought to determine its prognostic value in those with SHD.Methods: Patients with SHD to whom an implantable cardioverter defibrillator (ICD) was implanted in primary prevention from 2004 to 2015 were included.We determined the presence of ERP and other electrocardiographic (ECG) parameters.The primary endpoint was the occurrence of SCD or ventricular arrythmias (VA) requiring ICD therapies.Results: A total of 104 patients (mean age of 57615 years, 85% men) were included.Forty-two percent had ischemic cardiomyopathy.A mean of 8.165.5 ECG were analyzed in every patient, finding ERP in 28.8%.During a mean follow-up of 3.962.5 years, 30% of patients presented the primary endpoint.The proportion of patients with ERP was not different in patients who presented the primary endpoint compared to those who did not: 29.7% vs 26.7%, respectively (p¼0.76).Left ventricular ejection fraction, ventricular extrasystoles and atrial fibrillation at follow-up were independently associated to the primary endpoint (p<0.05).Conclusions: In our study, the presence of ERP in patients with SHD and an ICD implanted in primary prevention did not predict VA neither SCD. VENTRICULAR TACHYCARDIA ABLATIONP479 Three-dimensional dynamic fluoroscopic mapping of ventricular arrhythmias
Phytogenic fabrication of iron oxide nanoparticles and evaluation of their in vitro antibacterial and cytotoxic activity (2023)

Several metal-based nanoparticles (NPs) have been found to be toxic and are known to exert adverse health outcomes with irreversible side effects. This highlights the need to discover effective, stable, and biocompatible therapeutic components using natural sources. Here, a hexane extract of Nigella sativa seeds was used to synthesize iron oxide NPs (NS-IONPs) embedded with N. sativa phytoconstituents. The extract acted as a reducing agent that restricted the size of the NS-IONPs to 5–6 nm, signifying the potential to be cleared through the renal system. The fabricated NS-IONPs had a prominent effect on pathogenic gram-negative bacteria, E. coli (19.3 mm) and Salmonella typhi (14.2 mm) and lung cancer cells (lowest IC50 of 18.75 µg/mL) mainly by binding to the phospholipid components of the cell membrane. This resulted in cell shrinkage and further inhibited cell growth. Transmission electron microscopy analyses revealed that the mechanisms of cellular NP uptake varied depending on the cell type. Accumulation of NS-IONPs inside the cell increased BAX expression and arrested the cells at the G0/G1 phase, thereby conspicuously extending the G0 phase to initiate necrosis. Thus, these finding suggest that the synthesized NS-IONPs exhibited high antibacterial activity and effective cytotoxicity against cancer cell lines A549 and HCT116 compared to IONPs. The innovation of the current study is that the biogenic fabrication of IONPs is simple and cost effective results in stable nanomaterial, NS-IONPs with potential antibacterial and anticancer activity, which can be explored furthermore for various biomedical applications.
All-cause mortality in relation to changes in relative blood volume during hemodialysis (2018)

Specific hourly intradialytic RBV ranges are associated with lower all-cause mortality in chronic HD patients.
Multi-stage beamforming for interference coordination in massive MIMO networks (2015)

Recently we showed that the joint space division and multiplexing (JSDM) framework for massive MIMO can applied to hybrid beamforming for interference coordination between multiple base station sites. JSDM explicitly distinguishes between pre-beamforming based on long-term channel (covariance) statistics and precoding based on instantaneous channel state information. In this work provide we extend the JSDM framework to multiple base stations and demonstrate that already with a suboptimal solution using a limited set of predefined first-stage precoding vectors a huge portion of the gap between the uncoordinated and single-node case can be closed.