gebhart/patrepeval huggingface dataset:
Dynamic Range Requirements of Digital vs. RF and Tiled Beamforming in mm-Wave Massive MIMO (2021)

We analyze the required RF channel 1dB gain compression points and ADC resolution in mm-wave massive MIMO wireless communications hubs using RF beamformers, digital beamformers, and hybrid beamformers with coarse RF beamforming in the tiles and fine digital beamforming in the overall array. Given a 140GHz uplink, 16 users, 10Gb/s data rate per user, QPSK modulation, 5dB power levelling, and 32 or 64 RF channels, the three architectures require similar ADC resolution and similar 1dB gain-compression points, i.e. fully digital beamforming does not significantly increase the hardware requirements of the RF chain or ADC.
Clinoptilolite, a type of zeolite, by near ambient pressure-XPS (2020)

Near ambient pressure-x-ray photoelectron spectroscopy (NAP-XPS) is a less traditional form of XPS that allows samples to be analyzed at relatively high pressures, i.e., at greater than 2500 Pa. With NAP-XPS, XPS can probe moderately volatile liquids, biological samples, porous materials, and/or polymeric materials that outgas significantly. In this paper, we show the NAP-XPS survey; O 1s, Ca 2p, C 1s, K 2p, Al 2s, Al 2p, Si 2p, and Si 2s narrow scans; and the extended valence band spectrum of clinoptilolite, a natural zeolite that would be difficult to analyze by conventional XPS. A small N 1s signal from N2(g) is also observed in the survey spectrum. Signals in the narrow scans are fit to Gaussian–Lorentzian sum and Gaussian–Lorentzian product functions.
Brief Report: Defining the Nasal Transcriptome in Granulomatosis With Polyangiitis (Wegener's) (2015)

Profiling the nasal transcriptome in GPA reveals gene expression signatures related to innate immunity, inflammatory cell chemotaxis, extracellular matrix composition, and epithelial barrier integrity. Thus, airway-based expression profiling is feasible and informative in GPA.
Magnetic Resonance Imaging Artifact Associated With Transcutaneous Bone Conduction Implants: Cholesteatoma and Vestibular Schwannoma Surveillance (2023)

In summary, of the three device conditions (Osia with magnet, Osia without magnet, and Bonebridge), Osia without magnet offered the least amount of artifact and distortion and was the only condition in which diagnostic DWI was available for the middle ear and mastoid regions on the Siemens MR imaging scanner.
Abstract IA16: Engineered T cell therapies for cancer. (2013)

Abstract Chimeric antigen receptors (CARs) combine an antigen recognition domain of a specific antibody with a intracellular signaling domains into a single engineered protein. CD19 is an ideal target for CARs since expression is restricted to normal and malignant B cells. In preclinical studies, inclusion of the CD137 (4-1BB) signaling domain results in remarkable antitumor activity and in vivo persistence of anti-CD19 CARs. We have previously reported dramatic in-vivo expansion, persistence and anti-tumor activity of CAR modified autologous T cells targeted to CD19 (CART19 cells) in 3 patients with CLL with relatively short follow up (Porter, et al NEJM 2011; Kalos et al Sci Trans Med 2011). Currently, 11 patients have been treated with CART19 cells. There were 9 adults (median age 65 years (range 51-78)) treated for relapsed, refractory and high risk CLL and two pediatric cases treated for relapsed refractory pre-B cell ALL. CLL patients had received a median of 5 prior regimens excluding single agent rituxumab (range 2-10) and all had active disease at the time of cell infusion. The pediatric patients with ALL had chemotherapy refractory relapse, and one was resistant to allogeneic transplantation and CD19 directed blinotumomab. A median of 7.5 x 10^8 total cells (range 1.7-50) corresponding to 1.45 (range 0.14-5.9 x 108) genetically modified cells were infused. In the patients in complete remission, CAR modified CART19 cells are detectable in the peripheral blood by flow cytometry at the most recent follow up for at least 2 years. All patients in CR have B cell aplasia. No patient with CR has progressed. Citation Format: Carl H. June. Engineered T cell therapies for cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr IA16.
Synthesis of Gold Nanoparticles Grafted with a Thermoresponsive Polymer by Surface-Induced Reversible-Addition-Fragmentation Chain-Transfer Polymerization (2003)

This work focuses on the synthesis method of Au nanoparticles protected by a well-defined polymer monolayer. Nanosized, spherical gold clusters coated with poly(N-isopropylacrylamide) (PNIPA) grafts were prepared by controlled radical polymerization. The polymerization of N-isopropylacrylamide was initiated from the surface of a gold nanoparticle modified with 4-cyanopentanoic acid dithiobenzoate for a reversible-addition-fragmentation chain-transfer polymerization. The number mean diameter of the Au core was 3.2 nm as observed by high-resolution transmission electron microscopy. The molar mass of the PNIPA ligand was 21000 g/mol by gel permeation chromatography. The changes in the surface plasmon of gold were investigated in different media, and as functions of particle concentration, as well as of temperature in aqueous solutions. The particles were soluble at least slightly in water, forming aggregates. The area and the maximum wavelength of the plasmon band in water decreased with dilution and increasing temperature. During the collapse of PNIPA ligands the surroundings of the gold surface change from hydrophilic to hydrophobic.
Millimeter-Wave Generation in an Optoelectronic Oscillator Using an Ultrahigh Finesse Etalon as a Photonic Filter (2014)

A Fabry-Perot etalon with a finesse of 100 000 is used as a photonic filter in a single loop optoelectronic oscillator. The etalon provides narrow bandwidth microwave filtering at harmonics of its 1.5 GHz free spectral range for oscillation in the range of 6 to 60 GHz. Fiber delays as long as 2 km are added to the loop with no spurious modes visible above the noise floor. The environmental stability of the etalon makes it suitable as a secondary reference for feedback to the optical frequency which contributes to the reduction of phase noise and long term frequency drift.
Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone (2023)

Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment. A unique population of microglia reside in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence this neurogenic niche is not well-understood. Here, we demonstrate that phagocytosis creates a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1. Deletion of <i>Jedi-1</i> decreases apoptotic cell clearance, triggering the development of a neuroinflammatory phenotype, reminiscent of neurodegenerative and-age-associated microglia, that reduces neural precursor proliferation via elevated interleukin (IL)-1β signaling; inhibition of IL-1 receptor rescues precursor proliferation <i>in vivo</i>. Together, these results reveal a critical role for Jedi-1 in connecting microglial phagocytic activity to a phenotype that promotes neurogenesis in the developing V-SVZ.
Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis (2012)

Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles. From the observed correlation structure of 130 metabolites measured by nuclear magnetic resonance, we identified 11 metabolic networks and performed a multivariate genome-wide association analysis. We identified 34 genomic loci at genome-wide significance, of which 7 are novel. In comparison to univariate tests, multivariate association analysis identified nearly twice as many significant associations in total. Multi-tissue gene expression studies identified variants in our top loci, SERPINA1 and AQP9, as eQTLs and showed that SERPINA1 and AQP9 expression in human blood was associated with metabolites from their corresponding metabolic networks. Finally, liver expression of AQP9 was associated with atherosclerotic lesion area in mice, and in human arterial tissue both SERPINA1 and AQP9 were shown to be upregulated (6.3-fold and 4.6-fold, respectively) in atherosclerotic plaques. Our study illustrates the power of multi-phenotype GWAS and highlights candidate genes for atherosclerosis.
A LOW-COMPLEXITY APPROACH FOR INCREASING THE GRANULARITY OF PACKET-BASED FIDELITY SCALABILITY IN SCALABLE VIDEO CODING (2007)

Packet-based fidelity scalability (PFS) is a desirable fea-ture in many video coding or transmission applications. Any realization of PFS in a hybrid video coding approach, however, requires suitable concepts for controlling drift and for generating sufficiently small increments in bit rate in order to allow progressive refinements of perceptual quality relative to a given base layer quality. This paper addresses those problems in the context of the scalable video coding (SVC) extension of H.264/AVC. We pre-sent an algorithmically simple but yet remarkably well-performing method for packet-based fidelity scalability that is maximally consistent with the existing entropy cod-ing design of H.264/AVC, allows sufficiently small incre-ments in bit rate, and has been adopted as a normative element of SVC. We also discuss the benefits of the key picture concept of SVC in view of our proposed PFS ap-proach. Experimental results are presented that demon-strate the effectiveness of our method for a few selected SVC conforming encoder configurations. Index Terms — SVC, H.264/AVC, fidelity scalability,
Detection of DNA ofChlamydophila psittaciin subjects with psoriasis: a casual or a causal link? (2012)

Chlamydophila psittaci may be an infectious trigger possibly involved in the pathogenesis of psoriasis.
Detection of 100 molecules of product formed in a fucosyltransferase reaction (1994)

We present the detection of 100 molecules of enzyme substrate and product. A fucosyltransferase and a fucosidase were used to add and remove, respectively, a monosaccharide from a synthetic oligosaccharide fluorescently labelled with tetramethylrhodamine. The reaction was followed by use of capillary zone electrophoresis, to separate the product and reactant, with laser-induced fluorescence detection. These are the most sensitive enzyme assays reported to date and six orders of magnitude more sensitive than any reported for these two enzymes. This simple technology allows high-sensitivity determination of the activity of any enzyme for which a fluorescent substrate can be synthesized, and brings within reach the ability to assay glycosyltransferase activities in single cells.
Comparison of Multi-Objective Evolutionary Algorithms to Solve the Modular Cell Design Problem for Novel Biocatalysis (2019)

A large space of chemicals with broad industrial and consumer applications could be synthesized by engineered microbial biocatalysts. However, the current strain optimization process is prohibitively laborious and costly to produce one target chemical and often requires new engineering efforts to produce new molecules. To tackle this challenge, modular cell design based on a chassis strain that can be combined with different product synthesis pathway modules has recently been proposed. This approach seeks to minimize unexpected failure and avoid task repetition, leading to a more robust and faster strain engineering process. In our previous study, we mathematically formulated the modular cell design problem based on the multi-objective optimization framework. In this study, we evaluated a library of state-of-the-art multi-objective evolutionary algorithms (MOEAs) to identify the most effective method to solve the modular cell design problem. Using the best MOEA, we found better solutions for modular cells compatible with many product synthesis modules. Furthermore, the best performing algorithm could provide better and more diverse design options that might help increase the likelihood of successful experimental implementation. We identified key parameter configurations to overcome the difficulty associated with multi-objective optimization problems with many competing design objectives. Interestingly, we found that MOEA performance with a real application problem, e.g., the modular strain design problem, does not always correlate with artificial benchmarks. Overall, MOEAs provide powerful tools to solve the modular cell design problem for novel biocatalysis.
A formal model for reactive robot plans (2002)

An approach to the representation and analysis of flexible plans, i.e. plans that react to suit the current environment, is described. A formal model has been constructed for building and reasoning about such plans. The model can represent both the plan and the uncertain environment in which the plan is to be carried out. The concept of a flexible plan is demonstrated using a mixed-batch assembly example. A number of examples of uncertain and dynamic environments that can be represented are presented. The author's, approach is to use a special-purpose model of distributed computation in which plans are hierarchical networks of processes. This model has a rich vocabulary of composition operators for describing plans and world models. The plan analysis techniques are derived from the field of process algebra.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cross polarization from 1H to quadrupolar 6Li nuclei for dissolution DNP (2014)

Cross polarization from protons to quadrupolar (6)Li nuclei is combined with dynamic nuclear polarization of protons at 1.2 K and 6.7 T using TEMPOL as a polarizing agent followed by rapid dissolution. Compared to direct (6)Li DNP without cross-polarization, a higher nuclear spin polarization P((6)Li) can be obtained in a shorter time. A double resonance (1)H-(6)Li probe was designed that is equipped for Longitudinally Detected Electron Spin Resonance.
Periodontal regeneration with nano-hyroxyapatite-coated silk scaffolds in dogs (2013)

These observations indicate that nHA-coated silk scaffolds can be considered to be potentially useful biomaterials for periodontal regeneration.
Fabrication of silicon slot waveguides with 10nm wide oxide slot (2017)

We propose and demonstrate a fabrication technique to realize extremely narrow dielectric slots in silicon waveguides. Using this method, we have demonstrated a silicon slot waveguide with 10 nm dielectric slot with a measured propagation loss of 13.6 dB/cm.
Implementation of Low-Latency Signal Processing and Data Shuffling for TDD Massive MIMO Systems (2016)

Low latency signal processing and high throughput implementations are required in order to realize real-time TDD massive MIMO communications, especially in high mobility scenarios. One of the main challenges is that the up-link and down-link turnaround time has to be within the coherence time of the wireless channel to enable efficient use of reciprocity. This paper presents a hardware architecture and implementation of this critical signal processing path, including channel estimation, QRD-based MMSE decoder/precoder and distributed reciprocity calibration. Furthermore, we detail a switch-based router implementation to tackle the stringent throughput and latency requirements on the data shuffling network. The proposed architecture was verified on the LuMaMi testbed, based on the NI SDR platform. The implementation supports real-time TDD transmission in a 128 x 12 massive MIMO setup using 20 MHz channel bandwidth. The processing latency in the critical path is less than 0.15 ms, enabling reciprocity-based TDD massive MIMO for high-mobility scenarios.
Integration of AlN micromechanical contour-mode technology filters with three-finger dual beam AlN MEMS switches (2009)

In this paper, we present the first demonstration of the monolithic integration of Aluminum Nitride (AlN) micromechanical contour mode technology filters with dual-beam actuated MEMS AlN switches. This integration has lead to the development of the first prototype of a fully-integrated all-mechanical switchable filter. Integration has been demonstrated by using AlN contour-mode MEMS filters at two center frequencies, i.e. 98.7 and 279.9 MHz. The micromechanical switch design used here is a novel three-finger dual-beam topology that improves the isolation and insertion loss of the switch by decreasing the parasitic coupling between the DC and RF signals over a previous AlN MEMS dual beam design. With the use of just one switch fabricated right next to, and integrated with the filter, the AlN MEMS filter is effectively turned off and its pass-band transmission is lowered to the out of band level at 279.9 MHz.
Microfabrication Using Elastomeric Stamp Deformation (2006)

Elastomeric stamp deformation has been utilized for the contact printing (CP) of self-assembled monolayers (SAMs) and, more recently, polymers and proteins. Here, we take advantage of this well-studied phenomenon to fabricate a series of new metal thin-film patterns not present on the original stamp. The rounded patterns are of nanoscale thickness, long-range order, and are created from elastomeric stamps with only straight-edged features. The metal was printed onto the surface of an alpha,omega-alkanedithiol self-assembled monolayer (SAM). The new shapes are controlled by a combination of stamp geometry design and the application of external pressure. Previously published rules on stamp deformation for contact printing of SAMs are invalid because the coating is instead a thin-metal film. This method represents a new pathway to micropatterning metal thin films, leading to shapes with higher complexity than the original lithographic masters.
Free-form Köhler nonimaging optics for photovoltaic concentration (2010)

Concentration Photovoltaics (CPV) is one of the most promising areas for competitive solar electricity production. This promise relies upon the use of high-efficiency triple-junction solar cells (which already have proven efficiencies over 41%) and upon advanced optics designs, which allow for high concentration concurrent with high manufacturing tolerances, both key elements for low cost mass production. In this paper we will present the progress in the development of the most advanced CPV optical designs at present. These are based on free-form optics using Köhler homogenization. The degree of freedom of using free-forms allows the introduction of multiple functionalities in a few optical elements, which provide the required concentration with high tolerance and excellent light homogenization. Different families are presented. The first group uses a Fresnel lens as a primary optic (called the FK concentrator and the F-RXI concentrator) and a second group using mirrors as primaries (the XR and the XXR). How they compare among them and also with classical designs will be discussed. The FK is in the process of being brought to market and has already experimentally proven module electrical (DC) efficiencies over 30% (equivalent to over 32% with correction to Tcell=25ºC) with no AR coatings at a concentration of 625x with high tolerance angle (over ±1.2º).
Automatic Detection of Instruments in Laparoscopic Images: A First Step Towards High-level Command of Robotic Endoscopic Holders (2007)

The tracking of surgical instruments o fers interesting possibilities for the development of high-level commands for robotic camera holders in laparoscopic surgery. We have developed a new method to detect instruments in laparoscopic images which uses information on the 3D position of the insertion point of an instrument into the abdominal cavity. This information strongly constrains the search for the instrument in each endoscopic image. Hence, the instrument can be detected in near real-time using shape considerations. Early results on laparoscopic images show that the method is rapid and robust in the presence of partial occlusion and smoke. Our first experiment on a cadaver validates our approach and shows encouraging results.
p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells (1996)

Although epidermal growth factor (EGF) activates phosphoinositide (PI) 3-kinase activity in a number of types of cells or cell lines, in most cases that we have investigated the p85 regulatory subunit of PI 3-kinase does not appear to bind directly to the EGF receptor. Previously we demonstrated that EGF-dependent activation of PI 3-kinase activity in A431 cells is accompanied by the binding of p85 to ErbB3, an EGF receptor homologue. However, this mechanism did not explain the large activation of PI 3-kinase activity that was found in PC12 and A549 cells, which possess little or no ErbB3. Here we provide evidence that the p120cbl proto-oncoprotein is an intracellular adapter protein that associates with PI 3-kinase and thus is involved in the EGF-dependent activation of this enzyme in these two cell lines. Using an anti-p120cbl antibody, we immunoprecipitated the EGF receptor from PC12 cells and PI 3-kinase activity from PC12 and A549 cells in an EGF-dependent fashion. Treatment of PC12 cells with nerve growth factor or insulin stimulated large increases in PI 3-kinase activity that was immunoprecipitated using anti-Tyr(P) antibody but not using anti-p120cbl antibody. In EGF-treated PC12 cells, the tyrosine phosphorylation of p120cbl displayed similar kinetics to the activation of PI 3-kinase as measured by both in vivo lipid production and lipid kinase assays conducted using anti-p120cbl and anti-Tyr(P) immunoprecipitates. The use of glutathione S-transferase fusion proteins of various domains of p85 demonstrated that p120cbl associated with both the SH2 and SH3 domains of p85. p120cbl was also present in A431 cells and offers an additional pathway by which EGF can activate PI 3-kinase in these cells.
All-optical modulation of semiconductor laser by using three energy levels in n-doped quantum well (2005)

A new all-optical modulation of semiconductor laser is demonstrated by using three energy levels in n-doped quantum well. It is shown experimentally that the interband-light (semiconductor laser light) can be modulated by the intraband-light (CO/sub 2/ laser light).
Time domain thermoreflectance measurements and phonon gas modeling of the thermal conductivity of silicon doped indium phosphide pertinent to quantum cascade lasers (2023)

The thermal conductivity of Si-doped thin films of indium phosphide grown via metalorganic vapour-phase epitaxy at different carrier concentrations and thicknesses was measured from 80 to 450 K using time domain thermoreflectance. Additionally, phonon gas modeling was conducted to characterize the various scattering mechanisms that contribute to the thermal transport in these materials. A sensitivity analysis based on the phonon gas model showed that while thickness has a greater influence on the thermal conductivity than carrier concentration at the micron-scale for all samples, point defects due to Si-dopant atoms at carrier concentrations of ∼1019 cm−3, as well as the presence of extended defects that are most likely present due to dopant saturation, have a significant impact on thermal transport as a result of increased phonon scattering, decreasing the thermal conductivity by 40% or more.