gebhart/patrepeval huggingface dataset:
Sensitivity improvement in 44Sc whole gamma imaging: simulation study (2018)

We have proposed a new concept of whole gamma imaging (WGI), which is a combined Compton-PET system by inserting a scattering detector ring inside a PET detector ring. In addition to positron emitters, WGI can visualize single gamma emitters based on the Compton imaging method. Besides, for triple-gamma emitters such as <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">44</sup> Sc that emits a pair of 511 keV photons and a 1157 keV single gamma-ray almost at the same time, a direct imaging method would be possible; the source position will be calculated as an intersection point between a surface of the Compton cone and a line-of-response. In 2017, we succeeded in developing the world's first WGI prototype. However, limited sensitivity for Compton imaging degraded the system sensitivity for triple-gamma emitters. Therefore, in this work, we simulated the WGI system to optimize the scatterer detector for higher sensitivity. Using GEANT4, we modeled the WGI geometry, in which a scatter ring (GAGG crystals, 20 cm inner diameter) was inserted into a PET ring (GSOZ crystals, 66 cm inner diameter). In order to improve the sensitivity of triplegamma imaging and reduce parallax error, we used 4-layer depth-of-interaction (DOI) detectors as the scatterer. Total thickness of the scatterer was increased from 6 mm to 18 mm. However, thick scatterer also increased detection efficiency of 511 keV photons in the scatterer. Therefore, we improved the triple-gamma detection method in order to use the scatterer detection events of 511leV for triple-gamma imaging. Events in the scatterer were identified as positron annihilation and Compton scattering of the 1157 keV gamma-ray based on their energy information. The simulation results showed that (1) the sensitivity of the WGI using the 18-mm thick GAGG scatterer with the new triple-gamma detection method was 2.7 times higher than that of our first prototype (using 6-mm thick GAGG), and (2) the use of 4-layer DOI kept the position resolution in the triple-gamma imaging.
pH modulation using CsCl enhances therapeutic effects of vitamin D in LNCaP tumor bearing mice (2005)

The data presented in this manuscript is the first report of chemosensitization by in vivo pH modulation using CsCl in mice bearing prostate or any other tumor xenograft.
A high capacity noncoherent FSK lightwave field experiment using Er/sup 3+/-doped fiber optical amplifiers (1990)

A description is given of high-bit-rate fiber-optic noncoherent frequency-shift keying (FSK) transmission field experiments using Er/sup 3+/-doped optical amplifiers. Transmission distances of 70 km for a four-channel 6.8-Gb/s capacity experiment and 177 km for single-channel 1.7-Gb/s transmissions were demonstrated in a typical field environment. Measurements of receiver sensitivity dispersion penalty, interchannel crosstalk, and long-term bit-error-rate performance are presented. Results show negligible degradations due to >3000-ps/nm dispersion and interchannel crosstalk, in addition to stable long-term performance. This performance demonstrates the applicability of noncoherent FSK and fiber amplifier technologies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design, implementation, and performance analysis of a Stewart platform-based force sensor (2006)

International Research/Expert Conference: Trends in the Development of Machinery and Associated Technology (TMT), 2006, LLoret de Mar (España)
Nuclear receptors of the enteric tract: guarding the frontier (2008)

In addition to its classical role in mineral homeostasis, the vitamin D receptor has been implicated in diverse physiologic and pathophysiologic processes including immunoregulation and cancer. Interestingly, the vitamin D receptor has been evolutionarily and functionally linked to a select group of nuclear receptors based on a common organism-wide tissue expression profile. These members of the nuclear receptor superfamily, which include the bile acid receptor, xenobiotic receptors, and several orphan nuclear receptors, comprise a transcriptional regulatory network that functions in nutrient uptake, xenobiotic metabolism, and mucosal protection. The major homeostatic functions of the enteric nuclear receptor network are the topic of this review.
Cu-Promoted Fe2O3/MgO-Based Fischer–Tropsch Catalysts of Biomass-Derived Syngas (2014)

A series of precipitated Fe2O3/MgO catalysts incorporated with the copper promoter were prepared by the combination of coprecipitation and incipient witness impregnation methods. The catalysts were characterized by N2-adsorption–desorption isotherms, X-ray diffraction (XRD), H2 temperature-programmed reduction (H2-TPR), CO temperature-programmed desorption (CO-TPD), O2 temperature-programmed oxidation (O2-TPO), laser Raman spectroscopy (LRS), and X-ray absorption near edge structure (XANES). The Fischer–Tropsch (FT) synthesis reaction of the catalysts was also performed in a fixed bed reactor using different H2/CO ratios (H2/CO = 1 or 2). The characterization results indicated that Mg increases the BET surface area of precipitated oxide precursors by inhibiting sintering during thermal treatment, and leads to the formation of the relatively smaller iron crystallite size. Cu increases the rate of Fe2O3 reduction by providing H2 dissociation sites. The content of iron carbide phases during TPR process in the synthesis gas increases with the increase of copper content and reaches a maximum for the Cu/Fe atom ratio of 0.02. The optimal catalyst with Cu/Fe = 0.02 has high activity. A maximum in the catalytic activity and methane selectivity was obtained for the synthesis gas ratio of 2 (H2/CO = 2).
Shedding Light on the Stability and Structure–Property Relationships of Two-Dimensional Hybrid Lead Bromide Perovskites (2021)

Two-dimensional (2D) hybrid lead iodide perovskites have gained prominence due to their remarkable structural tunability, optoelectronic features, and moisture stability, which have rendered them as attractive alternatives to 3D MAPbI3 for optoelectronic devices. 2D multilayer lead bromide perovskites remain an unfathomed phase space with the lack of systematic studies to establish the structure, photophysical properties and stability behavior of this family of 2D halide perovskites. Herein, we present new members of bilayer lead bromide perovskites (CmH2m+1NH3)2(CH3NH3)Pb2Br7 (m = 6–8) that belong to the Ruddlesden–Popper structure type, incorporating long chain alkyl-monoammonium cations (CmH2m+1NH3) of hexylammonium (m = 6), heptylammonium (m = 7), and octylammonium (m = 8). A universal solution synthetic methodology for bulk multilayer lead bromide perovskites is presented with all structures solved and refined using single crystal X-ray diffraction. The studied bilayer lead bromide perovskites demonstrate a decrease in the lattice rigidity and lattice match of the inorganic perovskite layer–organic layer, as the alkyl-monoammonium chain length increases. In comparison to their iodide analogues, the bilayer lead bromide compounds exhibit elongation of their stacking axis despite the smaller dimensions of the [PbBr6]4− lattice, while their internal lattice strain was calculated to be reduced, inferring a greater lattice match between the inorganic [PbBr6]4− perovskite layer and organic layer. The (CmH2m+1NH3)2(CH3NH3)Pb2Br7 (m = 4, 6–8) compounds exhibit narrow-band emission near 2.5 eV. Time-resolved photoluminescence (PL) displays longer carrier lifetimes on the nanosecond time scale comparing to their iodide analogues, where electronic structure calculations indicate that the increase of the alkyl chain length and, thus, lattice softness enhances nonradiative recombinations. A complete set of air, light, and heat stability tests on unencapsulated thin films of (CmH2m+1NH3)2(CH3NH3)Pb2Br7 (m = 4, 6–8) and MAPbBr3 show they are stable in ambient air for at least 5 months, exhibiting greater extrinsic stability than the 2D lead iodide congeners. Extraordinarily, 3D MAPbBr3 films prove to be more stable than films of 2D lead bromide perovskites, in contrast to MAPbI3 which is less stable than the 2D lead iodide perovskites.
Challenges in Future Short Range Wireless Systems (2006)

As RF and baseband engineers strive to satisfy the demand for ever higher data rates in next generation wireless systems, they are faced with three challenging requirements: both spectral efficiency and bandwidth have to be increased, and the cost per bit has to be kept low. A combination of MIMO, OFDM and TDD is a promising candidate technology to meet these objectives. However, realizing the potential gains of this approach requires tackling a number of new challenges: real MIMO channels, real-"Dirty"-RF and tough real-time constraints
Properties and Production Experiences of TIMETAL®LCB for Automotive Spring Applications (2003)

&lt;div class="htmlview paragraph"&gt;&lt;i&gt;TIMETAL&lt;/i&gt;&lt;sup&gt;®&lt;/sup&gt; LCB is a low cost beta titanium alloy specifically designed for automotive coil spring applications. The advantages of beta titanium springs in automotive spring applications are due primarily to low density, low elastic modulus and excellent corrosion resistance. Over 20 ingots of &lt;i&gt;TIMETAL&lt;/i&gt;&lt;sup&gt;®&lt;/sup&gt; LCB have been produced since a large production ingot was first melted a few years ago.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper will provide the characteristics of &lt;i&gt;TIMETAL&lt;/i&gt;&lt;sup&gt;®&lt;/sup&gt; LCB that distinguish this alloy from other titanium alloys and steels. Mechanical and metallurgical properties of &lt;i&gt;TIMETAL&lt;/i&gt;&lt;sup&gt;®&lt;/sup&gt; LCB accumulated over several years will be summarized and discussed. The significant volume of production experiences of the alloy has enabled realistic specifications to be established for &lt;i&gt;TIMETAL&lt;/i&gt;&lt;sup&gt;®&lt;/sup&gt; LCB wire products.&lt;/div&gt;
Consumption of Content on the Web: An Ecologically Inspired Perspective (2016)

Thesis (Ph.D.) - Indiana University, Psychological and Brain Sciences and the Cognitive Science Program, 2016
Treatment of Murine Interferon-α/β-Sensitive and -Resistant Friend Leukemia Cells with Tumor Necrosis Factor in Combination with Murine Interferon-α/β or -γ (1986)

Interferon-alpha/beta (IFN-alpha/beta)-sensitive (FLC 745) and -resistant (FLC 3Cl8) Friend leukemia cells (FLC) were fairly refractory to the cytotoxicity of murine tumor necrosis factor (MuTNF) in vitro. Both lines became highly sensitive to mTNF when treated in combination with murine IFN-gamma; when treated with IFN-alpha/beta, only the FLC 745 became sensitive to MuTNF. Romeo et al. have reported previously that an antiviral state was induced in both FLC lines by IFN-gamma, but only in FLC 745 by IFN-alpha/beta. The present results suggest that the sensitivity to the synergistic cytotoxic effect of IFN and TNF in these cells is correlated with the ability to be induced into an antiviral state.
Trust Evaluation for Embedded SystemsSecurity research challenges identified from an incident network scenario (2011)

This paper is about trust establishment and trust evaluations techniques. A short background about trust, trusted computing and security in embedded systems is given. An analysis has been done of an incident network scenario with roaming users and a set of basic security needs has been identified. These needs have been used to derive security requirements for devices and systems, supporting the considered scenario. Using the requirements, a list of major security challenges for future research regarding trust establishment in dynamic networks have been collected and elaboration on some different approaches for future research has been done.This work was supported by the Knowledge foundation and RISE within the ARIES project.
A lung targeted miR-29 Mimic as a Therapy for Pulmonary Fibrosis (2021)

Abstract microRNAs are non-coding RNAs that negatively regulate gene networks. Previously, we reported a systemically delivered miR-29 mimic MRG-201 that reduced fibrosis in animal models, but at doses prohibiting clinical translation. Here, we generated MRG-229, a next-gen miR-29 mimic with improved chemical stability, conjugated with the internalization moiety BiPPB (PDGFbetaR-specific bicyclic peptide). In TGF-b-treated human lung fibroblasts and precision cut lung slices, MRG-229 decreased COL1A1 and ACTA2 gene expression and reduced collagen production. In bleomycin-treated mice, intravenous or subcutaneous delivery of MRG-229 downregulated profibrotic gene programs at doses more than ten-fold lower than the original compound. In rats and non-human primates, and at clinically relevant doses, MRG-229 was well tolerated, with no adverse findings observed. In human peripheral blood decreased mir-29 concentrations were associated with increased mortality in two cohorts potentially identified as a target population for treatment. Collectively, our results provide support for the development of MRG-229 as a potential therapy in humans with IPF. One Sentence Summary One Sentence Summary: A stabilized, next-generation miR-29 mimic has been developed that demonstrates efficacy at commercially viable doses with a robust safety margin in non-human primates.
Detection of betanodavirus in juvenile barramundi, Lates calcarifer (Bloch), by antigen capture ELISA (2006)

Betanodavirus infection of fish has been responsible for mass mortalities in aquaculture hatcheries worldwide. Betanodaviruses possess a bipartite single-stranded RNA genome consisting of the 3.1 kb RNA1 encoding an RNA-dependent RNA polymerase and the B2 protein, while the 1.4 kb RNA2 encodes the viral nucleocapsid protein, alpha. A panel of six monoclonal antibodies against the alpha protein of greasy grouper nervous necrosis virus (GGNNV) was developed for use in diagnostics. All antibodies reacted with native and recombinant alpha in immunoblot and indirect immunofluorescence assays. Each of the monoclonal antibodies reacted against discrete regions of the alpha protein, though none reacted with the extreme C-terminal region of the protein. One of the monoclonal antibodies, specific for the K151-T246 region of alpha, was used for the development of an antigen capture ELISA. In this assay we could detect 10(3)-10(4) TCID(50) units of virus derived from infected tissue culture supernatants. Head tissue extracts prepared from experimentally infected barramundi, Lates calcarifer, juveniles were assayed for GGNNV using the antigen capture assay and a clear increase in alpha antigen was detected from 5 to 15 days post-challenge. The assay thus represents a useful method for field-based detection of betanodavirus in fish hatcheries.
Search-based planning for a legged robot over rough terrain (2009)

We present a search-based planning approach for controlling a quadrupedal robot over rough terrain. Given a start and goal position, we consider the problem of generating a complete joint trajectory that will result in the legged robot successfully moving from the start to the goal. We decompose the problem into two main phases: an initial global planning phase, which results in a footstep trajectory; and an execution phase, which dynamically generates a joint trajectory to best execute the footstep trajectory. We show how R* search can be employed to generate high-quality global plans in the high-dimensional space of footstep trajectories. Results show that the global plans coupled with the joint controller result in a system robust enough to deal with a variety of terrains.
Impact of Water Coadsorption for Carbon Dioxide Capture in Microporous Polymer Sorbents (2012)

Alcohol-containing polymer networks synthesized by Friedel-Crafts alkylation have surface areas of up to 1015 m(2)/g. Both racemic and chiral microporous binaphthol (BINOL) networks can be produced by a simple, one-step route. The BINOL networks show higher CO(2) capture capacities than their naphthol counterparts under idealized, dry conditions. In the presence of water vapor, however, these BINOL networks adsorb less CO(2) than more hydrophobic analogues, suggesting that idealized measurements may give a poor indication of performance under more realistic carbon capture conditions.
Discrimination of Different Foodborne Pathogens onto Carbohydrate Microarrays Using Surface Plasmon Resonance Imaging (2015)

Food safety is a public health challenge. Devices allowing early, fast, label-free and in situ detection of bacteria are of great interest to prevent outbreaks. Listeria monocytogenes, Salmonella spp. and Escherichia coli O157:H7 are foodborne pathogens which were responsible of 60% of the hospitalizations in the USA in 2011. In this study, we conceived a carbohydrate microarray in order to detect and discriminate these three food pathogenic bacteria. In less than 10 hours, from an initial bacterial suspension of 100 bacteria per mL, Surface Plasmon Resonance imaging allowed the detection and the discrimination of these bacteria while they were growing and interacting specifically with the carbohydrate microarray. Moreover, this device is easily regenerable and can be re-used: it is probably a promising tool to early detect bacteria in food.
A structural parameter to link molecular geometry to macroscopic orientation in discotic liquid crystals: study of metalloporphyrin tapes (2021)

Novel liquid crystalline (LC) molecules were prepared from a dimeric porphyrin tape. A series of metal complexes (1Zn, 1Pd, 1Cu, and 1Ni) and the free-base form (12H) of the porphyrin tape formed a columnar LC phase. Although only the central metal ions were different among these compounds, 1Ni, 12H, and 1Cu aligned homeotropically in a sandwiched glass cell, while 1Zn and 1Pd exhibited a random orientation at a macroscopic scale. The strength of the π-π interactions, tunable by the distortion of the porphyrin cores through metallation, is a key factor for the observed macroscopic orientation difference.
The Second Life Ageing of the NMC/C Electric Vehicle Retired Li-Ion Batteries in the Stationary Applications (2016)

This work presents the lifetime degradation of second life batteries (commercial nickel manganese cobalt oxide based cathode and graphite based anode NMC/C) used in a stationary application that aims at mitigating the variability of a grid-scale PV power plant. Moreover, in this work, it is also investigated how battery cell history is affecting the performance of the second life battery pack.
Genomic Avenue to Avian Colisepticemia (2015)

Avian colisepticemia is a severe systemic disease of birds causing high morbidity and mortality and resulting in severe economic losses. The bacteria associated with avian colisepticemia are highly antibiotic resistant, making antibiotic treatment ineffective, and there is no effective vaccine due to the multitude of serotypes involved. To understand the disease and work out strategies to combat it, we performed an extensive genomic and genetic analysis of Escherichia coli strains of serotype O78, the major cause of the disease. We identified several potential virulence factors, conserved in all the colisepticemic strains examined, and determined their contribution to growth in serum, an absolute requirement for septicemia. These findings raise the possibility that specific vaccines or drugs can be developed against these critical virulence factors to help combat this economically important disease.
Organic Transistor Based on Cyclopentadithiophene‐Benzothiadiazole Donor–Acceptor Copolymer for the Detection and Discrimination between Multiple Structural Isomers (2019)

Abstract Distinguishing structural isomers is a critical and challenging task for biotechnology, chemical industry, and environmental monitoring. Approaches currently available are limited in terms of selectivity and simplicity. In this paper, a highly sensitive organic field‐effect transistor (OFET) using the cyclopentadithiophene‐benzothiadiazole (CDT‐BTZ) copolymers as a semiconductor is presented for easy and selective detection of different families of structural isomers, as well as between different isomers within each family. High accuracy discrimination is achieved over a range of concentrations using only a single sensing parameter derived from the OFET characteristic transfer curve. As a reference, other homopolymer‐ and donor–acceptor copolymer‐based OFET sensors are examined but do not have an equivalent sensing performance to that of the CDT‐BTZ‐based OFETs. Investigating the link between isomer absorption and swelling, supramolecular order and energy levels of the active layer reveals a unique effect of each isomer on the energy bands of the semiconducting polymer.
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1 −/− mice (2008)

We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also plays a role early in osteogenesis, and that in primary RB1(-/-) calvarial cells there is an increased osteoprogenitor pool. To understand pRb's function in vivo, we generated a conditional RB1-KO mouse in which pRb expression is efficiently extinguished in osteoblasts. These animals display an apparent developmental defect in bones, most strikingly in the calvaria. Cultured RB1(-/-) calvarial osteoblasts fail to cease proliferation upon reaching confluence or following differentiation. Re-plating assays of primary RB1(-/-) calvarial cells after differentiation showed a clear adipogenic ability with increased multipotency. RB1(-/-) osteoblasts display a severe reduction in levels of mRNAs expressed late in differentiation. In this study, we present strong evidence that pRb has multiple regulatory roles in osteogenesis. Furthermore, in the absence of RB1(-/-) there is a larger pool of multipotent cells compared with the WT counterpart. This increased pool of osteoprogenitor cells may be susceptible to additional transforming events leading to osteosarcoma, and is therefore key to understanding RB1 as a target in malignancy.
50-Gb/s Radio-over-Fiber System Employing MIMO and OFDM Modulation at 60 GHz (2012)

Record 50-Gb/s wireless signal transmission over 4 m is experimentally demonstrated using a 2×2 MIMO Radio-over-Fiber system at 60 GHz. MIMO spatial multiplexing and 16-QAM OFDM modulation were used to achieve a high combined spectral efficiency of up-to 8 b/s/Hz.
OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study (2017)

To evaluate alterations on optical coherence tomography angiography (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes with macular telangiectasia type 2 (MacTel type 2).