gebhart/patrepeval huggingface dataset:
Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO (2017)

Immunotherapy with short term infusion (STI) of monoclonal anti-GD<sub>2</sub> antibody (mAb) ch14.18 (4 × 25 mg/m<sup>2</sup>/d; 8-20 h) in combination with cytokines and 13-cis retinoic acid (RA) prolonged survival in high-risk neuroblastoma (NB) patients. Here, we investigated long-term infusion (LTI) of ch14.18 produced in Chinese hamster ovary cells (ch14.18/CHO; 10 × 10 mg/m<sup>2</sup>; 24 h) in combination with subcutaneous (s.c.) interleukin-2 (IL-2) in a single center program and report clinical response, toxicity and survival. Fifty-three high-risk NB patients received up to 6 cycles of 100 mg/m<sup>2</sup> ch14.18/CHO (d8-17) as LTI combined with 6 × 10<sup>6</sup> IU/m<sup>2</sup> s.c. IL-2 (d1-5; 8-12) and 160 mg/m<sup>2</sup> oral RA (d19-32). Pain toxicity was documented with validated pain scores and intravenous (i.v.) morphine usage. Response was assessed in 37/53 evaluable patients following International Neuroblastoma Risk Group criteria. Progression-free (PFS) and overall survival (OS) was analyzed by the Kaplan-Meier method and compared to a matched historical control group from the database of AIEOP, the "Italian Pediatric Ematology and Oncology Association". LTI of ch14.18/CHO showed acceptable toxicity profile indicated by low pain scores, reduced i.v. morphine usage and low frequency of Grade ≥3 adverse events that allowed outpatient treatment. We observed a best response rate of 40.5% (15/37; 5 CR, 10 PR), 4-year (4 y) PFS of 33.1% (observation 0.1- 4.9 y, mean: 2.2 y) and a 4 y OS of 47.7% (observation 0.27 - 5.20 y, mean: 3.6 y). Survival of the entire cohort (53/53) and the relapsed patients (29/53) was significantly improved compared to historical controls. LTI of ch14.18/CHO thus shows an acceptable toxicity profile, objective clinical responses and a strong signal of clinical efficacy in NB patients.
Technical Stability and Biological Variability in MicroRNAs from Dried Blood Spots: A Lung Cancer Therapy-Monitoring Showcase (2017)

We present a stable work flow for profiling of whole miRNomes on the basis of samples collected from DBS. Biological variations exceeded technical variations significantly. DBS-based miRNA profiles will potentially further the translational character of miRNA biomarker studies.
Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen (1999)

Rutin and quercetin absorption and metabolism were investigated in rats after in situ perfusion of jejunum plus ileum (15 nmol/min). In contrast to rutin, a high proportion of quercetin (two-thirds) disappeared during perfusion, reflecting extensive transfer into the intestinal wall. Net quercetin absorption was not complete (2.1 nmol/min), inasmuch as 52% were reexcreted in the lumen as conjugated derivatives (7.7 nmol/min). Enterohepatic recycling contribution of flavonoids was excluded by catheterization of the biliary duct before perfusion. After a 30-min perfusion period, 0.71 microM of quercetin equivalents were detected in plasma, reflecting a significant absorption from the small intestine. The differential hydrolysis of effluent samples by glucuronidase and/or sulfatase indicates that the conjugated forms released in the lumen were 1) glucuronidated derivatives of quercetin and of its methoxylated forms (64%) and 2) sulfated form of quercetin (36%). In vitro quercetin glucuronides synthetized using jejunal and ileal microsomal fractions were similar to those recovered in the effluent of perfusion. These data suggest that glucuronidation and sulfatation take place in intestinal cells, whereas no glucurono-sulfoconjugates could be detected in the effluent. The present work shows that a rapid quercetin absorption in the small intestine is very effective together with its active conjugation in intestinal cells.
Kinetics of ligand substitution in bis(N-tert-butylsalicylaldiminato)copper(II) in various alcoholic media: mechanism of the solvent path (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of ligand substitution in bis(N-tert-butylsalicylaldiminato)copper(II) in various alcoholic media: mechanism of the solvent pathHorst Elias, Uwe Froehn, Arved Von Irmer, and Klaus J. WannowiusCite this: Inorg. Chem. 1980, 19, 4, 869–876Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ic50206a016https://doi.org/10.1021/ic50206a016research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EUV mask shadowing effect modelling using a rigorous method (2007)

International audience
EVALUATION OF IN VIVO WEAR OF VITAMIN E-STABILIZED HIGHLY CROSS-LINKED POLYETHYLENE AT FIVE YEARS: A MULTICENTRE RADIOSTEREOMETRIC ANALYSIS STUDY (2018)

The primary purpose of the current study was to evaluate and compare the wear properties of vitamin E-doped, highly-crosslinked PE (VEPE) and one formulation of moderately cross-linked and mechanically-annealed ultra-high molecular weight PE (ModXLPE) in patients five years after primary THA. We also sought to understand whether polyethylene wear is associated with radiographic evidence of bone resorption or with deterioration in patient-reported outcome measures (PROMs). A total of 221 patients from four international centers were recruited into a prospective RSA and clinical outcomes study. Seventy percent (76%) of patients received VEPE (vs. ModXLPE) liners, and 36% received ceramic (vs. metal) femoral heads. PROMs and radiographs were collected preoperatively and at one, two, and five years postoperatively. In addition, RSA radiographs were collected to measure PE wear. We observed similar bedding in through the one-year interval and wear through the two-year interval between the two liner types. Howe...
Low Flow Anaesthesia (1997)

Low Flow Anaesthesia, Jan A. Baum. Oxford: Butterworth-Heinemann, 1996, ISBN 0-7506-2127-3, 208 pp, $75.00. This book provides a comprehensive survey of the published literature on low-flow anesthesia and describes the low-flow devices currently available. The reader quickly learns that Europe is technologically ahead of the USA in reducing flows to a closed circuit, since most of the commercial delivery systems described (e.g., PhysioFlex[R] by Physio Medical Systems BV, Haarlem, The Netherlands) are not yet available for sale in the USA. The author amply justifies the need for anesthesia machines to provide low-flow and closed-circuit anesthesia on clinical and economic grounds. The book extensively reviews 40 yr of publications, many of which are not often cited in today's literature. In several areas, it is difficult to determine which stated principles are meant to apply today and which should be discarded for real data. For example, the early 1980s requirement and reliance on 30% inspired oxygen to protect against hypoxia during both high- and low-flow anesthesia seems unjustified when oximetry is used. Also, dismissing manual liquid circuit injection without discussion, data, or evidence appears unjust. Mathematics is nicely avoided throughout most of the book. In the section on pharmacokinetics where some mathematics is presented, however, the distinction between exponential (e-t/t) and power function (t-1/2) relationships is not disclosed. The strengths and weaknesses of products available in the USA are not clearly stated. For example, the ability of the RAMAN Spectrometer (Ohmeda Inc., Madison, WI) to measure nitrogen is not adequately presented. Also, the marked differences in low-flow capability in Narkomed and Ohmeda machines is not sufficiently explored. Despite these few criticisms, Baum's Low Flow Anaesthesia is a good addition to the English-language literature on this technique that should be mastered by all practitioners. This book should be made available to all anesthesia trainees and should be read by anesthesiologists interested in this important anesthesia technique. James H. Philip, ME(E), MD Harvard Medical School; Department of Anesthesia; Brigham and Women's Hospital; Boston, MA 92115
Pixelated Silicon Photomultipler readout and organic scintillator detector assemblies. (2021)

Abstract not provided.
P53 GENE ALTERATIONS IN DIFFERENTIATED THYROID CANCERS (1995)

Analysis of 22 human thyroid cancers including papillary, follicular and medullary subtypes (PTC, FTC, MTC) by PCR-SSCP, and immunohistochemistry detected 4 deletions and 3 mutations. Deletions involved exons 1, 2-3 and 5-6 in 3 PTCs, mutations exons 2-3 in 2 MTCs and exons 8-9 in PTC4. p53 alterations occurred in 2/5 recurrent tumors and 2/3 tumors developing to cell lines. Immuno-histochemistry detected p53 mutations in differentiated areas of papillary thyroid cancers as frequent events occurring at stage T1 to T4 in contrast to prior findings by other authors which restrict p53 alterations to undifferentiated stages.
Association between the Charlson comorbidity index and outcomes after implantable cardioverter defibrillator generator replacement (2019)

CCI is predictive of mortality following ICD generator replacement. The benefit of ICD replacement in patients with CCI score ≥5 should be investigated in prospective studies.
Effect of Water Activity on the Growth Kinetics of Staphylococcus aureus in Ground Bread Crumb (2003)

ABSTRACT: The kinetics of Staphylococcus aureus (strains A, B, D) growth in bread crumb were determined as a function of water activity (A w ) from 0.836 to 0.909 at pH 5.2 to 5.5 and at 35°c. Adding glycerol to the dough or equilibrating the bread over saturated salt solutions adjusted the A w of the bread. Growth kinetics data, plotted as enumerated colony counts versus incubation time, were fitted using the logistic function to determine maximum growth rates. Similar maximum growth rates resulted, irrespective of the method used to adjust A w . Extrapolation of growth rate‐A w results predicts the A w corresponding to a zero growth rate.
An overview of Speech Recognition research at ICSI (1999)

Overview of speech recognition research at the International Computer Science Institute, and introduction to connectionist speech recognition.
In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer. (2012)

DB has potential as a new therapeutic agent against human CRC.
A 10 GHz Single-Crystalline Scandium-Doped Aluminum Nitride Lamb-Wave Resonator (2019)

This work reports on the first demonstration of Lamb-wave resonators based on single-crystalline Scandium (Sc)-doped Aluminum Nitride (AlN) films operating at 8-10 GHz. Sc-AlN and AlN films are grown on Silicon substrates using molecular beam epitaxy (MBE). The electrodes are defined using electron beam lithography with sub-micron feature sizes to maximize the electromechanical coupling coefficient (k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). A high k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> value of 4.8 % is reported at 9.9 GHz, with unloaded Quality factor (Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ) of 185, yielding f × Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> × k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> values of 74 GHz. The high k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is attributed to enhanced piezoelectric coefficients achieved due to single crystallinity, as well as Sc-doping. This work demonstrates higher performance resonators achieved by using single-crystalline Sc-AlN thin films compared to sputter-deposited films with sub-micron thicknesses, required for 5G filter applications.
Query-Adaptive Image Search With Hash Codes (2012)

Scalable image search based on visual similarity has been an active topic of research in recent years. State-of-the-art solutions often use hashing methods to embed high-dimensional image features into Hamming space, where search can be performed in real-time based on Hamming distance of compact hash codes. Unlike traditional metrics (e.g., Euclidean) that offer continuous distances, the Hamming distances are discrete integer values. As a consequence, there are often a large number of images sharing equal Hamming distances to a query, which largely hurts search results where fine-grained ranking is very important. This paper introduces an approach that enables query-adaptive ranking of the returned images with equal Hamming distances to the queries. This is achieved by firstly offline learning bitwise weights of the hash codes for a diverse set of predefined semantic concept classes. We formulate the weight learning process as a quadratic programming problem that minimizes intra-class distance while preserving inter-class relationship captured by original raw image features. Query-adaptive weights are then computed online by evaluating the proximity between a query and the semantic concept classes. With the query-adaptive bitwise weights, returned images can be easily ordered by weighted Hamming distance at a finer-grained hash code level rather than the original Hamming distance level. Experiments on a Flickr image dataset show clear improvements from our proposed approach.
Supramolecular hydrogels based on self‐assembly between PEO‐PPO‐PEO triblock copolymers and α‐cyclodextrin (2008)

This article reports a detailed study on the hydrogel formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers with alpha-cyclodextrin (alpha-CD) in aqueous solutions. The gelation kinetics and the gel rheological properties were studied using viscometry. The sol-gel phase transitions were studied using phase diagrams, while the gelation mechanism was studied using differential scanning calorimetric analysis. It was concluded that the gelation was induced by the complex formation between the PEO segments of the PEO-PPO-PEO triblock copolymer and alpha-CD, and the further self-assembly of the partially formed inclusion complexes. The addition of alpha-CD largely reduced the concentration of the copolymer needed for gel formation. The gels were thixotropic and reversible, and potentially suitable for use as an injectable drug-delivery system.
Pressure shielding mechanism of canopies for trailing edge noise reduction in aerofoils (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-3204.vid The pressure shielding mechanism of bio-inspired surface treatment, called canopies, has been investigated experimentally and applied to reduce trailing edge noise generated by aero- foils. Surface pressure experiments beneath the boundary layer on a flat and aerofoil section show that canopies can attenuate surface pressure in two frequency ranges, ∆ f 1 = 0.1 to 1.0 kHz and ∆f2 = 2 to 12 kHz, at some critical canopies’ height from the wall. Canopies with an Open-Area-Ratio (OAR or σ) of 50 % placed closer (h/δ=0.08) to the surface tend to in- crease attenuation with frequency, without any low-frequency peak attenuation. This high- frequency attenuation is mainly due to the mechanism of dissipation, of small-scale structures in the boundary-layer, provided by the canopies, which have relatively higher wall shear stress compared to flat plate or thicker canopy designs. As h/δ increases, the low-frequency atten- uation in the surface pressure becomes noticeable, with a peak value of 5 dB for a critical height of h/δ∗ ∼ 1, indicating the mechanism of blockage or shielding of large structures in the boundary-layer is responsible for the low-frequency attenuation. For h/δ ≥ 0.16, both the low- and high-frequency attenuation reduces and becomes almost zero for h/δ = 0.5. Furthermore, the mechanism of pressure shielding provided by the canopy treatment is shown to be a local phenomenon, for 70% <OAR < 90 % and very sensitive to the location of the canopy itself. The maximum attenuation in surface pressure is seen for the canopy geometries with small rod diameters with less spacing. The optimum canopy geometry, based on the surface pres- sure studies, was applied near the trailing edge of the NACA0012 aerofoil. The far-field noise study demonstrates, for the first time, that canopies can reduce broadband noise levels up to 12-14 dB in the frequency range between 2 and 12 kHz, provided they are scaled appropriately based on the incoming turbulent boundary-layer flow.
Exosomes: toward clinical application (2017)

エクソソームは，ほぼ全ての細胞から分泌される脂質二重膜で囲まれた100 nm前後の小胞であり，タンパク質，核酸，脂質，代謝産物などにより構成される．エクソソームの産生機構については，エンドサイトーシス経路を介して形成され，多胞体が原形質膜と融合して細胞外に放出されると考えられている．近年，エクソソームは細胞間で移送され機能することから，細胞間情報伝達に関与することが判明した．現在，様々な疾患の病態形成へのエクソソームの関与が解明され始めており，エクソソームの各種特徴に着目した診断や治療，そして核酸医薬の新規ドラッグデリバリーシステムとしても研究されている．まだ未解明の点が多くさらなる研究の発展が必要であるものの，今後の臨床応用が期待される．
Cell-Free Massive MIMO systems (2015)

Cell-Free Massive MIMO systems comprise a large number of distributed, low cost, and low power access point antennas, connected to a network controller. The number of antennas is significantly larger than the number of users. The system is not partitioned into cells and each user is served by all access point antennas simultaneously. In this paper, we define cell-free systems and analyze algorithms for power optimization and linear pre-coding. Compared with the conventional small-cell scheme, Cell-Free Massive MIMO can yield more than ten-fold improvement in terms of 5%-outage rate.
Fast ignition by laser driven particle beams of very high intensity (2007)

Anomalous observations using the fast ignition for laser driven fusion energy are interpreted and experimental and theoretical results are reported which are in contrast to the very numerous effects usually observed at petawatt-picosecond laser interaction with plasmas. These anomalous mechanisms result in rather thin blocks (pistons) of these nonlinear (ponderomotive) force driven highly directed plasmas of modest temperatures. The blocks consist in space charge neutral plasmas with ion current densities above 1010A∕cm2. For the needs of applications in laser driven fusion energy, much thicker blocks are required. This may be reached by a spherical configuration where a conical propagation may lead to thick blocks for interaction with targets. First results are reported in view of applications for the proton fast igniter and other laser-fusion energy schemes.
Ultra-Low Power Arrayed CMOS Silicon Photonic Transceivers for an 80 Gbps WDM Optical Link (2011)

We report an ultra-low power 80 Gbps arrayed silicon photonic transceiver for dense, large bandwidth inter/intra-chip interconnects. The hybrid CMOS transceiver consists of eight 10 Gbps WDM channels with total consumed power below 6 mW/channel.
Supplemental Table S3 from An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors (2023)

&lt;p&gt;Multivariable analysis of prognostic markers in endocrine-treated patients&lt;/p&gt;
Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location (2020)

As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor model, and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumor-associated immune cells. Tumor accumulation was evaluated for 55 × 60, 80 × 180, and 80 × 320 nm PRINT particles in four subcutaneous flank tumor models (SKOV3 human ovarian, 344SQ murine nonsmall cell lung, A549 human nonsmall cell lung, and A431 human epidermoid cancer). Each tumor model revealed specific particle accumulation trends with evident particle size dependence. Immuno-histochemistry staining revealed differences in tumor microvessel densities that correlated with overall tumor accumulation. Immunofluorescence images displayed size-mediated tumor penetration with signal from the larger particles concentrated close to the blood vessels, while signal fr...
Bound-Exciton and Edge-Emission Spectra Associated with Li and Na Acceptors in ZnSe (1989)

An alternative model for the radiative recombination process in ZnSe, responsible for the edge-emission bands associated with Li and Na acceptors, is tentatively proposed. This is derived from a recent experimental result showing that the energy level of a Na acceptor is shallower than that of a Li acceptor. The energy value of Na level is found to be 102 meV using results from direct observation of two-hole transitions. Significant Li contamination was observed in intentionally Na-doped ZnSe specimens which were heat-treated above 500°C. Both the Li bound exciton line and the related edge-emission band were found to decrease in intensity after prolonged exposure of the samples in air, whilst the Na bound exciton line remained constant.
Supplementary Figure S4 from CD44<sup>+</sup> Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell–Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1 (2023)

&lt;p&gt;Supplementary Figure S4. Anti-PD-1 blockade partially restores IFNÃŽÂ³ secretion by TILs against CD44+ SCCHN cells.&lt;/p&gt;
Advanced Formulation for DSA Resists (2016)

Arkema has developed two complementary strategies to enable early introduction of DSA technology into lithographic large nodes. The blend approach is a very powerful way to easily tune the reachable period. Special BCPs and blends enable to increase achievable BCP film thicknesses and to limit the defectivity leading to improved self-assembly's properties. Special BCPs specially prove dramatic improvement in the self-assembled features as regards to classical PS-b-PMMA systems of same dimension. Additionally, the processes for both of these systems are compatible with current end users' requirements.