gebhart/patrepeval huggingface dataset:
Shale Play Development Program Using Risk-Reward Mapping from Geospatial Analyses (2013)

Abstract Finding the best drilling locations in an extensive shale play holding is key to achieving production profile expectations and good economic metrics. Shale plays have been described as statistical plays. However, it becomes increasingly unacceptable to drill disappointing, underperforming wells as the operator and partners move from the exploration lifecycle stage into the appraisal and field development stages. The physical and chemical properties of shales dictate the economic success of development drilling programs. It is recognized that at least seven parameters must fall within empirically-determined ranges for a play to have economic production rates and estimated ultimate recovery (EUR) exceeding threshold internal rate of return (IRR) requirements. A geostatistical shale property workflow that high-grades 160-acre sections in a regional shale play, using a limited number of wellbores with standard logging suites is demonstrated. This paper extends the workflow from high-grading drilling targets to quantitative risk assessment. An application of the workflow to a multi-square mile U.S. shale play illustrates the analysis and its interpretation. The example shows that down-spacing well density in high-graded sections (high potential reward) is a quantitatively lower risk investment program than would normally be expected. Typically high reward opportunities, in the investment world, are expected to represent higher risk as well. Geostatistical analysis in the example play shows just the opposite behavior because the statistical nature of the local shale quality can be mapped and profitably drilled. Exploiting this geostatistical, high-grading workflow can accelerate an operator's development program with higher rewards, lower risk, and better rates of return than pursuing a uniform development program over a large regional play.
Continuous Renal Replacement Therapy in the Critically Ill Patient: From Garage Technology to Artificial Intelligence (2021)

The history of continuous renal replacement therapy (CRRT) is marked by technological advances linked to improvements in the knowledge of the mechanisms and kinetics of extracorporeal removal of solutes, and the pathophysiology of acute kidney injury (AKI) and other critical illnesses. In the present article, we review the main steps in the history of CRRT, from the discovery of continuous arteriovenous hemofiltration to its evolution into the current treatments and its early use in the treatment of AKI, to the novel sequential extracorporeal therapy. Beyond the technological advances, we describe the development of new medical specialties and a shared nomenclature to support clinicians and researchers in the broad and still evolving field of CRRT.
III/V nano ridge structures for optical applications on patterned 300 mm silicon substrate (2016)

We report on an integration approach of III/V nano ridges on patterned silicon (Si) wafers by metal organic vapor phase epitaxy (MOVPE). Trenches of different widths (≤500 nm) were processed in a silicon oxide (SiO2) layer on top of a 300 mm (001) Si substrate. The MOVPE growth conditions were chosen in a way to guarantee an efficient defect trapping within narrow trenches and to form a box shaped ridge with increased III/V volume when growing out of the trench. Compressively strained InGaAs/GaAs multi-quantum wells with 19% indium were deposited on top of the fully relaxed GaAs ridges as an active material for optical applications. Transmission electron microcopy investigation shows that very flat quantum well (QW) interfaces were realized. A clear defect trapping inside the trenches is observed whereas the ridge material is free of threading dislocations with only a very low density of planar defects. Pronounced QW photoluminescence (PL) is detected from different ridge sizes at room temperature. The potential of these III/V nano ridges for laser integration on Si substrates is emphasized by the achieved ridge volume which could enable wave guidance and by the high crystal quality in line with the distinct PL.
Treadmill-Based Locomotor Training With Robotic Pelvic Assist and Visual Feedback: A Feasibility Study (2020)

No adverse events were reported. Mean (SD) perceived exertion (3.61 (0.23)) was low and did not significantly change throughout the intervention. Overall adherence was 96.4%. Load asymmetry was not significantly reduced on the treadmill from baseline to posttraining (P = 0.075). Overground stance symmetry significantly improved on posttraining (F = 8.498, P = 0.002), but was not sustained at follow-up. (See the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A311, which summarizes the study background, methods, and results.) DISCUSSION AND CONCLUSIONS:: Results demonstrate this combined interventional approach was feasible and improved stance symmetry overground, yet further work should consider increasing training intensity and/or duration to induce gains lasting through follow-up.
Activation and diffusion studies of ion-implanted p and n dopants in germanium (2003)

We have demonstrated symmetrically high levels of electrical activation of both p- and n-type dopants in germanium. Rapid thermal annealing of various commonly implanted dopant species were performed in the temperature range of 600–850 °C in germanium substrates. Diffusion studies were also carried out by using different anneal times and temperatures. T-SUPREM™ simulations were used to fit the experimental profiles and to extract the diffusion coefficient of various dopants.
[LAV infections and the acquired immunodeficiency syndrome in infants]. (1986)

The clinical and immunologic abnormalities of 7 infants with Lymphadenopathy Associated Virus (LAV) infection are reported. Indicative immune changes, positive anti-LAV serologic test and/or virus isolation led to the diagnosis. In a case with a particularly severe form of the disease, whose mother died from AIDS, serologic tests and virus isolation were negative. Beside a case associated with blood transfusion, the familial and ethnic context helped the diagnosis. Clinical and biochemical features were close to those in adult AIDS, including hepatosplenomegaly, polyadenopathy, a decreased absolute number of OKT4(+) lymphocytes and hypergammaglobulinemia. The importance of cellular and sometimes also humoral immune deficiency was highly variable. For 4 patients, the severity of the immune deficiency allowed the diagnosis of AIDS. Occurrence of such an infection in the first months of life suggests a fetomaternal viral transmission; however, a postnatal contamination cannot be ruled out. Long-term prognosis is difficult to assess. It depends, among other factors, on the importance of the immune deficiency.
Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus (1992)

An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.
A Quasi-Mechanistic Mathematical Representation for Blood Viscosity (2017)

Blood viscosity is a crucial element for any computation of flow fields in the vasculature or blood-wetted devices. Although blood is comprised of multiple elements, and its viscosity can vary widely depending on several factors, in practical applications, it is commonly assumed to be a homogeneous, Newtonian fluid with a nominal viscosity typically of 3.5 cP. Two quasi-mechanistic models for viscosity are presented here, built on the foundation of the Krieger model of suspensions, in which dependencies on shear rate, hematocrit, and plasma protein concentrations are explicitly represented. A 3-parameter Asymptotic Krieger model (AKM) exhibited excellent agreement with published Couette experiments over four decades of shear rate (0–1000 s-1, root mean square (RMS) error = 0.21 cP). A 5-parameter Modified Krieger Model (MKM5) also demonstrated a very good fit to the data (RMS error = 1.74 cP). These models avoid discontinuities exhibited by previous models with respect to hematocrit and shear rate. In summary, the quasi-mechanistic, Modified-Krieger Model presented here offers a reasonable compromise in complexity to provide flexibility to account for several factors that affect viscosity in practical applications, while assuring accuracy and stability.
Caractérisation texturale par thermoporométrie et par adsorption‐désorption d'azote de résines à l'état gonflé (1982)

Abstract Thermoporometry is applied to determine the porous distribution of different resins in the swollen state. In some particular cases, a comparision is possible with results of the BET‐BJH methods applied to the same products dried by lyophylisation. Such a comparison enables a better understanding of the organisation and the formation of swollen systems. This determination of the porous texture of swollen resins is particularly useful for the understanding and the forecast of the general behaviour of resins.
OP:Sense - Eine Rapid Development Umgebung für die Entwicklung in der robotergestützten Chirurgie (2011)

Bei der Entwicklung und Forschung im Bereich der robotergestutzten Chirurgie muss viel Zeit aufgewendet werden um die Software, Sensorik und Aktorik zu einem funktionierendem Demonstrator zu kombinieren. Hierbei wird oft Zeit in Basistechniken investiert, die zwar im Prinzip bekannt und vorhanden, aber nicht im konkreten Kontext verfugbar sind. Auch bei verfugbaren Softwarepaketen wie Slicer ist eine Integration in die bestehende Infrastruktur nicht trivial. Wunschenswert ware eine Entwicklungsumgebung, die moglichst hohe Echtzeitanforderungen erfullt, eine einfache modellbasierte Entwicklung ermoglicht sowie geringe Anforderungen an die verwendeten Betriebssysteme stellt. Weitere erstrebenswerte Eigenschaften sind die Moglichkeit, einfache Versuche oder Auswertungen zu scripten, das Vorhandensein von einfach zu implementierenden Schnittstellen, einer integrierten Simulationsumgebung fur das Robotersystem und einer direkten Formulierungsmoglichkeit fur mathematische Probleme. Ein Losungsentwurf, der diese Anforderungen bereits zu weiten Teilen erfullt, wird hier vorgestellt. Die beschriebene Umgebung wurde und wird im Rahmen der Arbeit an vier verschiedenen EU-Forschungsprojekten des sechsten und siebten Rahmenprogrammes entwickelt und wurde bereits mit verschiedenen Partnern genutzt. Ziel ist die Etablierung eines OpenSource Projektes speziell fur die robotergestutzte Chirurgie. Schlusselworte: RAD, Chirurgie, Robotik, Haptik, Bildgebung
Withdrawn as duplicate: Optimized Implementation of cardiac resynchronization therapy – a call for action for referral and optimization of care (2021)

Ahead of Print article withdrawn by publisher. This article has been withdrawn due to a publisher error that caused the article to be duplicated. The definitive version of this article is published under https://doi.org/10.1093/europace/euaa411.
SAFETY PERFORMANCE EVALUATION OF MINNESOTA'S ALUMINUM WORK ZONE SIGNS (2002)

A wide variety of traffic controlling devices are used in work zones, some of which are not normally found on the roadside or in the traveled way outside of the work zones. These devices are used to enhance the safety of the work zones by controlling the traffic through these areas. Due to the placement of the traffic control devices, the devices themselves may be potentially hazardous to both workers and errant vehicles. The impact performance of many work zone traffic control devices is mainly unknown and to date limited crash testing has been conducted, under the criteria of National Cooperative Highway Research Program (NCHRP) Report No. 350, Recommended Procedures for the Safety Performance Evaluation of Highway Features. The objective of the study was to evaluate the safety performance of existing aluminum sign support systems through full-scale crash testing. A total of six full-scale crash tests were conducted on sign supports to determine their safety performance according to the Test Level 3 (TL-3) criteria set forth in the NCHRP Report No. 350. Two of the six impacts on the sign support systems resulted in acceptable safety performances. Following the analysis of these crash tests as well as the test results from other testing programs, it has been found that slight variations in design features of the work zone traffic control devices can lead to very different performance results. Therefore, extreme care should be taken in applying crash test results from one work zone traffic control device to similar work zone traffic control devices with slight variations. The results of the crash tests were documented, and conclusions and recommendations pertaining to the safety performance of the existing work zone traffic control devices were made.
Determining the Correlation Between Core Performance and Golf Swing Kinematics and Kinetics (2010)

responses to numerous questions during this project and throughout my time at Ohio State.I am extremely thankful that he enabled me to pursue a project on a topic that was especially interesting to me.In addition, I would also like to thank Jimmy Onate
Vapor diffused optical waveguides in strontium barium niobate (SBN: 60) (1986)

Single mode planar and channel waveguides have been produced in Sr0.6Ba0.4Nb2O6 (tungsten bronze structure) by sulfur diffusion in a sealed ampule, followed by oxidation in an open tube. Losses in channel waveguides were ∼15–20 dB/cm for TM polarization and ∼27–32 dB/cm for the TE polarization in z-cut substrates. Electro-optic modulation was observed after poling of the substrate. The experimentally determined value of the effective electro-optic coefficient was slightly greater than reported earlier for bulk samples of SBN:60, and about 15 times greater than for LiNbO3. Based on measurements with the S35 radioisotope, the average atomic sulfur concentration was estimated to be about 4×1017/cm3 in the region extending from the surface to a depth of 2.5 μm, and a significant background concentration (∼5×1016/cm3) was present to depths in excess of 20 μm.
Dynamics of Dual Networks: Strain Rate and Temperature Effects in Hydrogels with Reversible H-Bonds (2017)

Combining high concentration of reversible hydrogen bonds with a loosely cross-linked chemical network in poly(N,N-dimethylacrylamide-co-methacrylic acid) hydrogels produces dual-network materials with high modulus and toughness on par with those observed for connective tissues. The dynamic nature of the H-bonded cross-links manifests itself in a strong temperature and strain rate dependence of hydrogel mechanical properties. We have identified several relaxation regimes of a hydrogel by monitoring a time evolution of the time-average Young’s modulus ⟨E(t)⟩ = σ(t)/ε̇t as a function of the strain rate, ε̇, and temperature. At low temperatures (e.g., 3 °C), ⟨E(t)⟩ first displays a Rouse-like relaxation regime (⟨E(t)⟩ ∼ t–0.5), which is followed by a temporary (physical) network regime (⟨E(t)⟩ ∼ t–0.14) at intermediate time scales and then by an associating liquid regime (⟨E(t)⟩ ∼ t–0.93) at the later times. With increasing temperature to 22 °C, the temporary network plateau displays lower modulus values, narrows, and shifts to shorter time scales. Finally, the plateau vanishes at 37 °C. It is shown that the energy dissipation in hydrogels due to strain-induced dissociation of the H-bonded cross-links increases hydrogel toughness. The density of dissipated energy at small deformations scales with strain rate as UT ∼ ε̇0.53. We develop a model describing dynamics of deformation of dual networks. The model predictions are in a good agreement with experimental data. Our analysis of the dual network’s dynamics provides general frameworks for characterization of such materials.
An Evaluation Cascade for G-Quadruplex Telomere Targeting Agents in Human Cancer Cells (2009)

The targeting of telomerase and telomere maintenance in human cancer cells can be achieved by small molecules that induce the 3'single-stranded ends of telomeric DNA to fold up into four-stranded quadruplex structures that inhibit the action of the telomerase enzyme complex. In this chapter, we describe a series of biochemical, biophysical, and cellular assays that are used to evaluate the activity of new compounds, and so assess whether they are suitable for examination in xenograft models of human cancer. These assays evaluate quadruplex stabilisation properties, short- and long-term cell viability, telomerase enzymatic activity, cellular senescence, and telomere length changes.
ChemInform Abstract: Control of Selectivities in Palladium‐Catalyzed Reactions (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lighting interpolation by shadow morphing using intrinsic lumigraphs (2003)

Densely-sampled image representations such as the light field or lumigraph have been effective in enabling photorealistic image synthesis. Unfortunately, lighting interpolation with such representations has not been shown to be possible without the use of accurate 3D geometry and surface reflectance properties. In this paper we propose an approach to image-based lighting interpolation that is based on estimates of geometry and shading from relatively few images. We decompose captured light fields at different lighting conditions into intrinsic images (reflectance and illumination images), and estimate view-dependent scene geometries using multi-view stereo. We call the resulting representation an intrinsic lumigraph. In the same way that the lumigraph uses geometry to permit more accurate view interpolation, the intrinsic lumigraph uses both geometry and intrinsic images to allow high-quality interpolation at different views and lighting conditions. Joint use of geometry and intrinsic images is effective in the computation of shadow masks for shadow prediction at new lighting conditions. We illustrate our approach with images of real scenes.
Selection of Optimised Ligands by Fluorescence-Activated Bead Sorting (2023)

The chemistry of aptamers is largely limited to natural nucleotides, and although modifications of nucleic acids can enhance target aptamer affinity, there has not been a technology for selecting the right modifications in the right locations because enzymatic amplification does not transmit sequence-specific modification information. Here we show the first method for the selection of specific nucleoside modifications that increase aptamer binding efficacy, using the oncoprotein EGFR as a model target. Using fluorescent-activated bead sorting (FABS), we have successfully selected optimized aptamers from a library of >65,000 variations. Hits were identified by tandem mass spectrometry and validated by using an EGFR binding assay and computational docking studies. Our results provide proof of concept for this novel strategy for the selection of chemically optimised aptamers and offer a new method for rapidly synthesising and screening large aptamer libraries to accelerate diagnostic and drug discovery.
High-resolution imaging system using a tabletop extreme ultraviolet source (2004)

We present a simple setup for obtaining high resolution, sub-micron images using high harmonic generation (HHG) in a hollow-core waveguide as a light source. We demonstrate imaging with illumination at a wavelength of 30 nm using an all-reflective, double-multilayer mirror setup and a CCD camera as a recording device. For the magnifications of up to 50x used here, the all-reflective setup has advantages over zone plate microscopes because of the much larger working distances that allow for imaging of plasmas. This setup has also a throughput that is higher by at least a factor of three compared to zone-plate microscopes, and presents the additional advantage of preserving the temporal pulse width of the harmonics because diffractive optics are not used. This work demonstrates the feasibility of high-spatial-resolution, time-resolved, EUV imaging of plasmas and other objects using a tabletop compact light source.
Retrospective study of glaucoma and closed-eyelid test: long-term outcomes in an Italian native population. (2012)

AIM: To establish a threshold value of intraocular pressure (IOP) increase after the closed-eyelid test (CET) that correlates with the highest probability of developing overt primary open-angle glaucoma (OAG) in an Italian native population from 1980 to 2010. METHODS: Retrospective analysis of data obtained from 161 patients with ocular hypertension who performed the CET in 1980, and were subsequently followed to see whether they developed OAG. CET was performed always in the morning Eyelids were closed by bandaging for 1 h in a quiet environment, with the patient seated and not sleeping. IOP was measured again 8 to 10s after opening the eyelids. RESULTS: Accurate statistical analysis of the obtained values indicated that 77% of the subjects showing an IOP increase after 1 hour of eyelid closure in a sitting position developed OAG in the following 30 years and that IOP increase values above 4 mmHg led to a subsequent diagnosis of glaucoma in more than 80% of the patients. CONCLUSION: Eyelid closure for 60 minutes results in a net elevation of IOP the extent of which depends on the balance between the increase of aqueous humour secretion and its outflow. Therefore, the CET may discriminate individuals with a normal outflow from individuals with a less functional outflow, which are evidently those at a higher risk of developing glaucoma.
One-Pot, Three-Component Approach to the Synthesis of 3,4,5-Trisubstituted Pyrazoles (2015)

An operationally simple and high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-pot, three-component coupling of aldehydes, 1,3-dicarbonyls, and diazo compounds as well as tosyl hydrazones. The reaction proceeds through a tandem Knoevenagel condensation, 1,3-dipolar cycloaddition, and transition metal-free oxidative aromatization reaction sequence utilizing molecular oxygen as a green oxidant. The scope of the reaction was studied by varying the aldehyde, 1,3-dicarbonyl, and diazo component individually.