gebhart/patrepeval huggingface dataset:
MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors (2016)

Germ cell tumors (GCT) are the most common malignancies in males between 15 and 35 years of age. Despite the high cure rate, achieved through chemotherapy and/or surgery, the molecular basis of GCT etiology is still largely obscure. Here, we show a positive correlation between MAPK15 (ERK8; ERK7) expression and specific GCT subtypes, with the highest levels found in the aggressive embryonal carcinomas (EC). Indeed, in corresponding cellular models for EC, MAPK15 enhanced tumorigenicity in vivo and promoted cell proliferation in vitro, supporting a role for this kinase in human GCT. At molecular level, we demonstrated that endogenous MAPK15 is necessary to sustain cell cycle progression of EC cells, by limiting p53 activation and preventing the triggering of p53-dependent mechanisms resulting in cell cycle arrest.To understand MAPK15-dependent mechanisms impinging on p53 activation, we demonstrate that this kinase efficiently protects cells from DNA damage. Moreover, we show that the ability of MAPK15 to control the autophagic process is necessary for basal management of DNA damage and for tumor formation controlled by the kinase.In conclusion, our findings suggest that MAPK15 overexpression may contribute to the malignant transformation of germ cells by controlling a "stress support" autophagic pathway, able to prevent DNA damage and the consequent activation of the p53 tumor suppressor. Moreover, in light of these results, MAPK15-specific inhibitors might represent new tools to enhance the therapeutic index of cytotoxic therapy in GCT treatment, and to increase the sensitivity to DNA-damaging drugs in other chemotherapy-resistant human tumors.
HES1 Cooperates With pRb to Activate RUNX2-Dependent Transcription (2006)

These data indicate that pRb acts as a RUNX2 co-activator at least in part by recruiting HES1 into the pRb/RUNX2 complex and further elucidate a novel role for pRb as a transcriptional co-activator in osteogenesis.
Design, Synthesis, and Properties of Inorganic and Hybrid Thin Films Having Periodically Organized Nanoporosity (2008)

This review presents an extensive discussion on the major advances in the field of periodically organized mesoporous thin films (POMTFs) obtained via surfactant templated growth of inorganic or hybrid polymers. A large variety of templating agents can be coupled with inorganic polymerization reactions for the design of periodically organized nanostructured hybrid phases that yield POMTFs. The tuning of the interface between the template and the polymerizing phase and the control over chemical and processing conditions are the key parameters in producing tailor-made POMTFs with a high degree of reproducibility. This dynamic coupling between chemical and processing conditions dictates extensive use of complementary ex situ measurements with in situ characterization techniques that follow, in real time, film formation from the molecular precursor solutions to the final stabilized POMTF. Among modern analytical tools, 2D-GISAXS, ellipsoporosimetry, HRTEM, X-ray reflectometry, WAXS, time-resolved infrared spectroscopy, SAW, and optically polarized xenon NMR have proved to be highly relevant for this purpose. POMTFs combine the intrinsic physical and chemical properties of the inorganic or hybrid matrices with a highly defined nanoporous network having a tunable pore size and connectivity, high surface area and accessibility, and a specific orientation with respect to the substrate. As such, POMTFs are a promising family of advanced materials for a host of future applications including micro-optics and photonic devices, microelectronics, nanoionics and energy, environment, functional and protective coatings, biomaterials, environmentally responsive materials, and biomicrofluidics, among others.
Electrochemical Analysis of Narcotic Drugs Using Nanomaterials ModifiedElectrodes – A Review (2023)

Abstract: The usage of abused illicit drugs remains an increasing challenge for drug regulatory authorities and therefore, it is important to develop advanced sensor technology that able to identify and determine drugs concentration in seized samples, biological fluids and food samples. The World Health Organization (WHO) recommends the usage of narcotic drugs legally for the medical treatments. Thus, many reports indicated that the higher dosage level led to drug addiction and mental disorders in humans. The United States record showed about 0.46 million cases of deaths due to the overdose of opioids-related drugs every year. This review discusses the electrochemical analysis (DPV, CV, EIS spectra, etc.) of various narcotic drugs using electrochemical transducers made of nanomaterials such as gold nanoparticles, single-walled carbon nanotubes, Zn2SnO4/graphene nanocomposite, cysteamine functionalized gold nanoparticle conjugated with an aptamer, etc. There were many challenges reported during the electroanalysis of narcotic drugs. Some of the wearable devices were also made for the sensing of narcotic drugs. Specifically, electro-analysis of nicotine, morphine, codeine and cathonine using 2D nanomaterials and their nanocomposites-based electrochemical sensors fabricated on flexible substrates were discussed. In particular, the linear range of detection, limit of detection (LOD), interference and real-world sample analysis were highlighted. It was concluded that wearable sensors could be used for the monitoring of illicit drugs and their derivatives in day-to-day life.
A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients (2020)

The addition of hydroxychloroquine to preoperative gemcitabine and nab-paclitaxel chemotherapy in patients with resectable pancreatic adenocarcinoma resulted in greater pathologic tumor response, improved serum biomarker response, and evidence of autophagy inhibition and immune activity.
Solid-State NMR Investigations of Peptide−Lipid Interaction and Orientation of a β-Sheet Antimicrobial Peptide, Protegrin (2002)

Protegrin-1 (PG-1) is a broad-spectrum beta-sheet antimicrobial peptide found in porcine leukocytes. The mechanism of action and the orientation of PG-1 in lipid bilayers are here investigated using (2)H, (31)P, (13)C, and (15)N solid-state NMR spectroscopy. (2)H spectra of mechanically aligned and chain-perdeuterated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) bilayers indicate that PG-1 at high concentrations destroys the orientational order of the aligned lamellar bilayer. The conformation of the lipid headgroups in the unoriented region is significantly altered, as seen from the (31)P spectra of POPC and the (2)H spectra of headgroup-deuterated 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine. These observations indicate that PG-1 disrupts microbial membranes by breaking the extended bilayer into smaller disks, where a significant fraction of lipids is located in the edges of the disks with a distribution of orientations. These edges allow the lipid bilayer to bend back on itself as in toroidal pores. Interestingly, this loss of bilayer orientation occurs only in long-chain lipids such as POPC and not in shorter chain lipids such as 1,2-dilauroyl-sn-glycero-3-phosphatidylcholine (DLPC). To understand the mode of binding of PG-1 to the lipid bilayer, we determined the orientation of PG-1 in DLPC bilayers. The (13)CO and (15)N chemical shifts of Val-16 labeled PG-1 indicate that the beta-strand axis is tilted by 55 degrees +/- 5 degrees from the bilayer normal while the normal of the beta-sheet plane is 48 degrees +/- 5 degrees from the bilayer normal. This orientation favors interaction of the hydrophobic backbone of the peptide with the hydrophobic core of the bilayer and positions the cationic Arg side chains to interact with the anionic phosphate groups. This is the first time that the orientation of a disulfide-stabilized beta-sheet membrane peptide has been determined by solid-state NMR.
Comparison of Organic Monolayers on Polycrystalline Gold Spontaneously Assembled from Solutions Containing Dialkyl Disulfides or Alkanethiols (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of Organic Monolayers on Polycrystalline Gold Spontaneously Assembled from Solutions Containing Dialkyl Disulfides or AlkanethiolsHans A. Biebuyck, Colin D. Bain, and George M. WhitesidesCite this: Langmuir 1994, 10, 6, 1825–1831Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/la00018a034https://doi.org/10.1021/la00018a034research-articleACS PublicationsRequest reuse permissionsArticle Views1486Altmetric-Citations301LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lateral stress relaxation and collapse in lipid monolayers (2008)

Surfactants at air/water interfaces are often subjected to mechanical stresses as the interfaces they occupy are reduced in area. The most well characterized forms of stress relaxation in these systems are first order phase transitions from lower density to higher density phases. Here we study stress relaxation in lipid monolayers that occurs once chemical phase transitions have been exhausted. At these highly compressed states, the monolayer undergoes global mechanical relaxations termed collapse. By studying four different types of monolayers, we determine that collapse modes are most closely linked to in-plane rigidity. We characterize the rigidity of the monolayer by analyzing in-plane morphology on numerous length scales. More rigid monolayers collapse out-of-plane via a hard elastic mode similar to an elastic membrane, while softer monolayers relax in-plane by shearing.
Targeted Single-Site MOF Node Modification: Trivalent Metal Loading via Atomic Layer Deposition (2015)

Postsynthetic functionalization of metal organic frameworks (MOFs) enables the controlled, high-density incorporation of new atoms on a crystallographically precise framework. Leveraging the broad palette of known atomic layer deposition (ALD) chemistries, ALD in MOFs (AIM) is one such targeted approach to construct diverse, highly functional, few-atom clusters. In this paper, we demonstrate the saturating reaction of trimethylindium (InMe<sub>3</sub>) with the node hydroxyls and ligated water of NU-1000, which takes place without significant loss of MOF crystallinity or internal surface area. We computationally identify the elementary steps by which trimethylated trivalent metal compounds (ALD precursors) react with this Zr-based MOF node to generate a uniform and well characterized new surface layer on the node itself, and we predict a final structure that is fully consistent with experimental X-ray pair distribution function (PDF) analysis. Finally, we further demonstrate tunable metal loading through controlled number density of the reactive handles (–OH and –OH<sub>2</sub>) achieved through node dehydration at elevated temperatures.
High spatial resolution reconstruction technique for SPECT using a fan-beam collimator (1993)

The physical characteristics of the collimator cause degradation of resolution with increasing distance from the collimator surface. A convolutional backprojection algorithm is derived for fan beam single-photon-emission computed tomography (SPECT) data without rebinding into parallel beam geometry. The projections are filtered and then backprojected into the area within an isosceles triangle whose vertex is the focal point of the fan-beam and whose base is the fan-beam collimator face, and outside of the circle whose center is located midway between the focal point and the center of rotation and whose diameter is the distance between the focal point and the center of rotation. Consequently, the backprojected area is close to the collimator surface. This algorithm, implemented on a GCA-9300A SPECT system, shows good results with phantom and patient studies. The SPECT transaxial resolution is 4.6 mm FWHM (reconstructed image matrix size of 256*256) at the center of SPECT field of view using ultra-high-resolution fan beam collimators for brain study. Clinically, Tc-99m HMPAO and Tc-99m ECD brain data are reconstructed using this algorithm. The reconstruction results are compared with MRI images of the same slice position and show significant improvement over results obtained with standard reconstruction algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design of an efficient light-emitting diode with 10 GHz modulation bandwidth (2008)

We present a high-speed light-emitting-diode (LED) design for efficient modulation at speeds higher than 10 GHz. It relies on a tensile-strain GaAsP quantum well coupled with surface plasmon polaritons on a silver surface. We present optical pumping experiments showing a tenfold reduction in carrier lifetime when the quantum well is located 40 nm above the silver surface. We believe this represents the first step toward an efficient LED compatible with 10 GHz modulation speed for use in short distance optical communication systems.
Cell to Cell Communication (2010)

ABSOLUTELY DELIGHTED to be here and to tell you about how bacteria talk to each other. I appreciate being invited and I'm glad to get my turn to contribute to today's different topics. I have only one goal in today's seminar, and that is to try to convince you that bacteria can indeed talk to each other. If I can convince you of that, my secondary goal is to try to show you that bacteria are multilingual. We've known about bacteria for almost 400 years. I think that you probably all that bacteria are considered the most primitive organisms on earth. They are single cells, and the way that they grow is that they consume nutrients from the environment. They double their size, they cut themselves in half, and they make two from one. For 390 of the 400 years that we've known about bacteria they've always been considered to live asocial, reclusive lives. They divide in half and each sibling goes out and does its own thing and doesn't know anything about his brother or sister.
Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen (2010)

Combining flavopiridol with 4OH-Tam potently inhibited the growth of RT cells by increasing the ability of either drug alone to induce caspases 2 and 3 thereby causing apoptosis. The potency of flavopiridol was enhanced by abrogation of p53. Our results warrant further studies investigating the combinatorial effects of flavopiridol and 4OH-Tam as a novel therapeutic strategy for RTs and other tumors that have been shown to respond to flavopiridol.
Adipose Tissue-Derived Stem Cells As A Regenerative Therapy for A Mouse Steatohepatitis-Induced Cirrhosis Model (2013)

These results suggest that ADSC therapy is beneficial in cirrhosis, as it can repair and restore the function of the impaired liver.
The Calculation of Temperature and Thermal Stress Distributions in the Planar Solid Oxide Fuel Cell (1992)

Abstract The temperature and thermal stress distributions in a planar solid oxide fuel cell (SOFC) were calculated using a finite element method in order to determine guidelines for the selection of cell materials. The calculations indicate that the thermal stress is generated in a planar SOFC composed of yttria stabilized zirconia (YSZ) electrolyte, a LaMnO3 cathode, and a Ni-YSZ cermet anode. The largest stress is generated in the region of the cathode material. According to the calculations, if the linear expansion of the cathode material is 1.0 × 10−6 (the linear expansion of porous LaMnO3 is 2.0 × 10−5), the thermal stress in the SOFC will be relieved.
Distribution of Acid Protease Activity in the Squid Nervous System (1984)

Acid protease activity was measured in homogenized stellate ganglion, axoplasm extruded from the squid giant axon, homogenized fin nerves, and in lysed synaptosomes prepared from the optic lobe of the squid. At least two different acid protease classes were distinguished on the bases of their inhibitor profiles. Acid protease activity was present in each of the above tissues except extruded axoplasm. This result suggests that the acid protease activity found in our homogenized fin nerves might be located not within the axons but rather in glial cells or extracellular tissue. The absence of acid protease activity in extruded axoplasm indicates that acid proteases are unlikely to play a significant role in the catabolism of intracellular proteins along the length of the axon.
A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4Receptor Agonists (2009)

5-HT(4) receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of intestinal propulsion, abdominal bloating, and pain. The 5-HT(4) receptor binding site can accommodate functionally and sterically diverse groups attached to the amine nitrogen atom of common ligands, occupying what may be termed a "secondary" binding site. Using a multivalent approach to lead discovery, we have investigated how varying the position and nature of the secondary binding group can be used as a strategy to achieve the desired 5-HT(4) agonist pharmacological profile. During this study, we discovered the ability of amine-based secondary binding groups to impart exceptional gains in the binding affinity, selectivity, and functional potency of 5-HT(4) agonists. Optimization of the leads generated by this approach afforded compound 26, a selective, orally efficacious 5-HT(4) agonist for the potential treatment of gastrointestinal motility-related disorders.
Study on Water Leak-Tightness of Small Leaks on A 1 Inch Cylinder Valve (2002)

Practical thresholds for water leak-tightness of small leaks were determined by experimentation. Measurements for small leak samples were taken of air leakage rates and water leakage rates for identical leak samples in order to identify parameters that influence water leak-tightness threshold. Four types of leaks were evaluated: a fine wire inserted in an O-ring seal, a glass capillary tube, a stainless steel orifice, and a scratched valve stem on a 1-inch UF6 cylinder valve. Experimental results demonstrated that the key parameter for water leak-tightness is the opening size of the leak hole. The maximum allowable hole size to achieve water leak-tightness ranged from 10 to 20 μm in diameter in this study. Experimental results with 1 inch UF6 cylinder valve samples demonstrated that the acceptance criteria for preshipment leakage test, 1 × 10−3 ref-cm3.s−1, as prescribed in ANSI N14.5 is an appropriate value from the point of view of water leak-tightness for enriched UF6 packages. The mechanism of water leak-tightness is plugging by tiny particles existing in water. The water used in experiments in this study contained far fewer particles than in water assumed to be encountered under accident conditions of transport. Therefore, the water leak-tightness threshold determined in this study is a conservative value in a practical evaluation.
De-multiplexer of wavelength division multiplexed radio-over-fiber signal for application of W-band frequency-modulated continuous-wave radar systems (2014)

The characteristics of a newly-developed de-multiplexer for wavelength-division-multiplexed (WDM) radio-overfiber (RoF) signal, which is applicable for frequencymodulated continuous-wave (FM-CW) radar systems, is investigated and the de-multiplexing of 4-channel WDM 32-GHz-band FM-CW RoF signal is demonstrated.
Multi-Array Designs for mmWave and Sub-THz Communication to UAVs (2020)

Unmanned Aerial Vehicles (UAVs) are steadily being considered for scenarios demanding high bandwidth, low latency communications for video and sensor data transfer as well as real-time control. UAVs may also be used as mobile aerial Base Station (BS) for maintaining the communication in emergency scenarios. The millimeter wave (mmWave) bands, including the sub-THz frequencies above 100 GHz, are an attractive technology for high data rate UAV connectivity due to the wide bandwidths available at these frequencies. This paper studies antenna and codebook design for UAV communication at both 28 and 140 GHz with realistic antenna simulations and flight patterns. The analysis shows that multi-array configurations with proper codebook design are necessary for uniform spherical coverage and become particularly important in long range applications. The paper thus proposes a four array design with patch antennas. Simulations indicate that the design can achieve in excess of 1 Gbps data rates at a range of 1 km, with reasonable power levels and moderate rain fades. A simulation with a real public safety mission flight shows that beam tracking can be maintained even under high drone movements and rotations.
Nanoparticle dispersion in disordered porous media with and without polymer additives (2016)

In purely viscous Newtonian fluids, mechanical mixing of the fluid stream as it moves through an unstructured porous medium controls the long-time dispersion of molecular tracers. In applications ranging from environmental remediation to materials processing, however, particles are transported through porous media in polymer solutions and melts, for which the fluid properties depend on the shear rate and extent of deformation. How the flow characteristics of polymer solutions affect the spreading of finite-sized particles remains poorly understood - both on the microscopic scale as local velocity profiles, and on the macroscale as dispersion. Here, we show across a range of flow rates and disordered porous media configurations that the long-time transport coefficients of particles flowed in water, in a viscous Newtonian fluid, and in a non-Newtonian shear-thinning polymer solution collapse onto scaling curves, independent of the fluid rheology. Thus the addition of polymer does not impact nanoparticle dispersion through disordered porous media.
Cover Feature: Conducting Redox Polymer as a Robust Organic Electrode‐Active Material in Acidic Aqueous Electrolyte towards Polymer–Air Secondary Batteries (ChemSusChem 9/2020) (2020)

The Cover Feature shows a polymer–air secondary battery composed of a naphthoquinone-based conducting redox polymer as a paintable and robust organic anode material and a Pt/C catalyst as a cathode-active material operating in an acidic aqueous electrolyte. More information can be found in the Full Paper by K. Oka, C. Strietzel, et al. on page 2280 in Issue 9, 2020 (DOI: 10.1002/cssc.202000627).