gebhart/patrepeval huggingface dataset:
Influence of Timing and Predicted Risk on Mortality in Impella-Treated Infarct-Related Cardiogenic Shock Patients (2020)

<b>Background:</b> In-hospital mortality in acute myocardial infarction-related cardiogenic shock (AMI-CS) remains high. The only adequately powered randomized trial showed no benefit of routine use of the intra-aortic balloon pump in AMI-CS. We compared individually predicted mortality using CardShock- and IABP-Shock II-scores in AMI-CS patients treated with an Impella microaxial pump, who met the IABP-Shock II-trials inclusion/exclusion criteria, to observed mortality on circulatory support in order to determine whether standardized use of an Impella microaxial flow-pump in AMI-CS is associated with lower than predicted mortality rates and whether timing of implantation or selecting patients based on predicted risk is meaningful. <b>Methods and Results:</b> We analyzed data from 166 consecutive Impella-treated AMI-CS patients meeting the inclusion/exclusion criteria of the IABP-Shock II-trial (age 64 ± 11 years). Thirty-nine percentage of 64 patients had been resuscitated before Impella implantation. Overall 30-day mortality was 42%. Mortality was higher in resuscitated patients (50 vs. 36%, <i>p</i> = 0.0452) and when Impella was implanted post-PCI (Impella-pre-PCI: 28%, Impella-post-PCI: 51%, <i>p</i> = 0.0039). While in both score systems there was no significant difference between predicted and observed overall 30-day mortality, predicted mortality was significantly higher than observed mortality on Impella support only for individuals with highest predicted risk based on CardShock score (predicted 77 vs. observed 51%, <i>p</i> = 0.025). <b>Conclusions:</b> Our retrospective analysis suggests that the use of the Impella microaxial pump may be effective in selected cases of high risk patients with AMI-CS. <b>Condensed abstract:</b> Mortality is high in acute myocardial infarction-related cardiogenic shock despite rapid revascularization. Haemodynamic support with an intraortic balloon pump does not reduce mortality. In this retrospective registry including 166 consecutive IABP-Shock II-eligible cardiogenic shock patients in four dedicated shock centers, observed mortality on circulatory support with an Impella was significantly lower than predicted in patients with highest mortality risk. Implantation prior to PCI in acute myocardial infarction-related cardiogenic shock seemed to be associated with lower mortality than implantation post PCI.
Involvement of interleukin-3 in delayed-type hypersensitivity. (1998)

The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity.
Recursive Identification and Scaling of Non-linear Systems using Midpoint Numerical Integration (2010)

Anewrecursivepredictionerroralgorithm(RPEM)basedonanonlinear ordinary differential equation (ODE) model of black-box state space form is presented. The selected model is discretised by a midpoint integration algorithm and compared to an Euler forward algorithm. When the algorithm is applied, scaling of the sampling time is used toimprove performance further. This affects the state vector, the parameter vector and the Hessian. This impact is analysed and described in three Theorems. Numerical examples are provided to verify the theoretical results obtained. 1
Outcomes for Recurrent Mantle Cell Lymphoma Post-Ibrutinib Therapy: A Retrospective Cohort Study from a Japanese Administrative Database (2022)

Patients with MCL previously treated with ibrutinib have poor ability to carry out ADL and experience very poor outcomes. New safe, effective therapies are needed.
Rare-earth aluminate crystals for fluorescence thermometer application (2004)

Rare-earth aluminate crystals have the advantage of chemical and thermal stability as the sensor materials of a fiber-optic fluorescence thermometer. Among many rare-earth aluminate crystals, rare-earth garnet, Y/sub 3/Al/sub 5/O/sub 12/, doped with Cr/sub 2/O/sub 3/, is found to be useful as the sensor material for a fluorescence thermometer. Temporal characteristics of fluorescence from Cr doped Y/sub 3/Al/sub 5/O/sub 12/ crystals are comparable to that of ruby (Cr doped Al/sub 2/O/sub 3/) crystal.
DNA vaccine VGX-3100 with electroporation induces regression of cervical intraepithelial neoplasia 2/3 and clears HPV infection with robust T cell responses: results of a randomized, double-blind, placebo-controlled Phase II trial (2014)

Meeting abstracts The Phase II study, designated HPV-003 ([NCT01304524][1]), assessed the safety and efficacy of VGX-3100 in 167 women with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 or CIN 3 and HPV-16 or -18. The randomized, placebo-controlled, double-blind study, was stratified by
SOI-KF: Distributed Kalman Filtering With Low-Cost Communications Using the Sign of Innovations (2006)

When dealing with decentralized estimation, it is important to reduce the cost of communicating the distributed observations-a problem receiving revived interest in the context of wireless sensor networks. In this paper, we derive and analyze distributed state estimators of dynamical stochastic processes, whereby the low communication cost is effected by requiring the transmission of a single bit per observation. Following a Kalman filtering (KF) approach, we develop recursive algorithms for distributed state estimation based on the sign of innovations (SOI). Even though SOI-KF can afford minimal communication overhead, we prove that in terms of performance and complexity it comes very close to the clairvoyant KF which is based on the analog-amplitude observations. Reinforcing our conclusions, we show that the SOI-KF applied to distributed target tracking based on distance-only observations yields accurate estimates at low communication cost
Figure S3-S4 from Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression (2023)

&lt;p&gt;Figure S3 shows A-FABP expression in TAM of human breast tissues. Figure S4 analyzes macrophage depletion in spleen of WT and A-FABP-/- mice.&lt;/p&gt;
Total retinal thickness: a neglected factor in the evaluation of inner retinal thickness (2022)

The previously reported ethnic differences in layer thickness among groups are likely driven by differences in total retinal thickness. Our results suggest using layer thickness ratio (retinal layer thicknesses/total retinal thickness) rather than absolute thickness values when comparing retinal layer thicknesses across groups.
Diglycidylether of iso-eugenol: a suitable lignin-derived synthon for epoxy thermoset applications (2016)

Iso-eugenol (isoEu), catalytically fragmented from lignin, is converted into a diglycidylether of iso-eugenol (DGE-isoEu) which leads in the presence of anhydride acids based hardeners to new biobased epoxy thermosets.
High Time Resolution Q-Band EPR Study of Sequential Electron Transfer in a Triad Oriented in a Liquid Crystal (2001)

Using high time resolution Q-band EPR we have been able to identify three different radical pairs generated by pulsed laser excitation of the fixed distance triad consisting of a zinc-9-desoxo-meso-methylpyrochlorophyllide donor (ZC), a pyromellitimide primary acceptor (PI), and a naphthalene-1,8:4,5-diimide secondary acceptor (NI), i.e., ZC−PI−NI, oriented in a liquid crystal. Analysis of the transient EPR spectra provides direct evidence for sequential electron transfer from the primary to the secondary radical pair of the triplet channel. At room temperature, this process occurs with an exponential time constant of τT,2 = 50 ± 1 ns. In the singlet-initiated channel, the intramolecular electron-transfer rates are too fast for direct EPR detection. Thus, even the secondary singlet radical pair [ZC•+PINI•-]S is formed instantaneously on the time scale of the EPR experiment. The species decays with a time constant of τS,3 = 36 ± 1 ns by charge recombination to the singlet ground state. The time evolution of the transverse magnetization exhibits fast initial oscillations, which disappear 50 ns after the laser pulse. Model calculations indicate that these oscillations can be assigned to zero quantum electron precessions in [ZC•+PINI•-]S. Thus, for the first time, quantum beats have been observed from a spin-correlated radical pair, oriented in a liquid crystal.
1,2-Bis(diphenylphosphino)ethane (2001)

[1663-45-2] C26H24P2 (MW 398.42) InChI = 1S/C26H24P2/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)21-22-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20H,21-22H2 InChIKey = QFMZQPDHXULLKC-UHFFFAOYSA-N (ligand for metal-catalyzed allylic alkylation;1 decarboxylation of allylic esters;2 1,3-diene synthesis;3 cycloaddition reactions;4 carbonylation reactions5) Alternate Name: DIPHOS; dppe. Physical Data: mp 140–142 °C. Solubility: sol THF, CHCl3, CH2Cl2, Et2O, and other organic solvents. Form Supplied in: white solid; widely available. Handling, Storage, and Precautions: solutions are readily oxidized to the phosphine oxide and should be handled under N2 or Ar. Solid samples can be handled in air. DIPHOS exhibits cytotoxic activity.
Infantile sialic acid storage disease (ISSD). Report on first case in Czech Republic with biopsy and autopsy findings. (1993)

The first case of infantile sialic acid storage disease in Czech Republic is presented in a four-and-half year-old girl. The clinical phenotype consisted of moderate hepatosplenomegaly and skin hypopigmentation, early psychomotoric and developmental arrest, associated with truncal ataxia and lower extremities spasticity, extinguished acoustic and visual perception (optic atrophy without macular alteration) and remarkable automutilation phenomena. The appearance was normosomatic and there were minimal dysostotic changes. Skin and liver biopsy displayed moderate amount of lucent storage lysosomes in epithelial, mesenchymal, and neural elements. Alder-Reily granules were found in the bone marrow and peripheral blood cells. The urinary excretion of mucopolysaccharides and oligosaccharides was not increased. The autopsy showed heterogenous neuronal and glial brain storage (lucent lysosomes, lipopigment, membranous cytoplasmic bodies), severe hypomyelination and severe storage in the splenic sinus endothelium. Diagnosis was made by proving thirteen fold increase of free sialic acid in the fibroblast culture. It is pointed out that in the case of a mucopolysaccharidosis-like storage disease unexplainable by a hydrolytic enzyme deficiency, it is the enzyme product storage which must be suspected. At present, the only candidate is the sialic acid storage disease.
Supplementary Materials and Methods from Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency (2023)

&lt;p&gt;Additional information about experimental techniques and materials relevant to this study&lt;/p&gt;
A denial of property rights: knowing receipt and Byers v Saudi National Bank (2023)

Journal Article A denial of property rights: knowing receipt and Byers v Saudi National Bank Get access Toby Graham, Toby Graham Partner and Head of Contentious Trusts and Estates, Farrer & Co, 66 Lincoln’s Inn Fields, London WC2A 3LH, UK Email: Toby.Graham@Farrer.co.uk Search for other works by this author on: Oxford Academic Google Scholar David Russell David Russell AM KC, Outer Temple Chambers, 222 Strand, London, UK, and The Gate, DIFC, Dubai, UAE. Email: David.RussellKC@outertemple.com Search for other works by this author on: Oxford Academic Google Scholar Trusts & Trustees, Volume 29, Issue 4, May 2023, Pages 293–298, https://doi.org/10.1093/tandt/ttad018 Published: 10 May 2023
Midinfrared power delivery through chalcogenide glass-clad optical fibers (1996)

Chalcogenide glass cladded optical fibers of As-S-Se core/As-S cladding compositions are being developed at the Naval Research Laboratory. Results of testing these fibers for high power transmission in the 2 - 6 micrometers wavelength region using various laser sources are presented. These sources include a CW CO laser (5.4 micrometers ) and a pulsed OPO (2 - 4 micrometers ). In addition, telluride glass fibers (transmission from 3 - 12 micrometers ) have been tested with CW CO<SUB>2</SUB> laser input. Power handling capability has been assessed during laser irradiation by both visual observation of fiber endfaces using a microscope/camera apparatus and by measuring any reduction in power transmission.
Mechanistic Studies of Catalytic Olefin Dimerization Reactions Using Electrophilic η3-Allyl−Palladium(II) Complexes (1996)

The dimerization of olefins by well-defined cationic η3-allyl−palladium complexes of the type [(C3H5)Pd(L)(PR3)]+[BAr‘4]- (Ar‘ = [3,5-C6H3(CF3)2]; L = OEt2, H2O; R = cyclohexyl (Cy), n-butyl (nBu)) has been studied. These complexes react with ethylene or methyl acrylate at −80 °C with loss of L to form the η2-olefin complexes [(C3H5)Pd(η2-olefin)(PR3)]+[BAr‘4]- (olefin = H2CCH2, CH2CHC(O)OCH3). Upon warming, allyl−olefin coupling occurs. The dimerization of ethylene occurs rapidly at 0 °C with an observable ethyl−ethylene intermediate [(C2H5)Pd(C2H4)2(PCy3)]+[BAr‘4]-. Methyl acrylate reacts to form a stable acrylate chelate complex, [(CH3O(O)CCH2CH2)Pd(CH2CHC(O)OCH3)(PR3)]+[BAr‘4]-, which is the catalyst resting state for methyl acrylate dimerization which occurs at room temperature to give predominantly trans-dimethyl-2-hexenedioate.
Capacity of mmWave MIMO-Systems Using a Wideband Indoor Channel Model (2019)

To make the huge bandwidths in the license free millimeter wave (mmWave) band available for consumer products like wireless local area network (WLAN), novel physical challenges have to be overcome. Spatial sparsity, huge pathloss and expensive implementation of analog hardware have lead to the concept of hybrid analog and digital architectures that are well known in the technical community by now. In contrast to classical multiple-input multiple-output (MIMO) systems in the legacy bands, where signal processing can be done fully digital (FD), hybrid concepts come with constraints in terms of flexibility, performance and signal processing overhead. Thus, as soon as progress in hardware- and material science will allow to produce cost- and energy efficient radio frequency (RF) components, the ability to implement FD MIMO designs in the mmWave bands will allow to overcome those constraints. In this paper we investigate how typical mmWave channels allow to make use of FD MIMO in terms of performance improvements and up to which number of spatial streams gains can be expected. We analyze achievable rates based on the channel model of the latest WLAN standard IEEE 802.11ay (11ay) in the scenario of an indoor conference room and application oriented design parameters. Further, we compare results to a more basic narrowband channel model that is often used in academia. Results show that when two spatial separated antenna arrays in a FD system are used, rate improvements of up to ≈ 92% under line-of-sight (LOS)-, and ≈ 79% under non-LOS (NLOS)-conditions can be expected, if ten spatial streams rather than two are transmitted.
Psychometric correlates of the effects of image-enhancing algorithms on visual performance (2006)

Future military imaging devices will have computational capabilities that will allow agile, real-time image enhancement. In preparing for such devices, numerous image enhancement algorithms should be studied. However, these algorithms need evaluating in terms of human visual performance using military-relevant imagery. Evaluating these algorithms through objective performance measures requires extensive time and resources. We investigated several subjective methodologies for down-selecting algorithms to be studied in future research. Degraded imagery was processed using six algorithms and then ranked along with the original non-degraded and degraded imagery through the method of paired comparisons and the method of magnitude estimation, in terms of subjective attitude. These rankings were then compared to objective performance measures: reaction times and errors in finding targets in the processed imagery. In general, we found associations between subjective and objective measures. This leads us to believe that subjective assessment may provide an easy and fast way for down-selecting algorithms but at the same time should not be used in place of objective performance-based measures.
P1‐203: Verification of the Analytical Performance of the Fully Automated Lumipulse g β‐Amyloid 1‐42 and Lumipulse g Total TAU Assays (2016)

Today β-amyloid(1-42) peptide (Aβ1-42) and total tau protein levels in cerebrospinal fluid (CSF) are well-accepted biomarkers representing Alzheimer’s disease (AD) progression from the earliest stages on. Widespread use of these biomarkers in AD diagnosis requires reliable, highly precise and accurate measurements. The current study evaluates the novel Lumipulse® G β-Amyloid 1-42 and Lumipulse® G Total Tau assays on these analytical aspects. The LUMIPULSE® G instrument series use single, ready-to-use immunoreaction cartridges with a throughput of 60 and 120 tests/hour for the G600II and the G1200 instrument, respectively. Each cartridge generates quantitative results for one biomarker within approximately 30 minutes and multiple assays can be easily combined in the system enabling full characterization of samples during one run. The Lumipulse G β-Amyloid 1-42 and Lumipulse G Total Tau assays were developed using established monoclonal antibodies. Analytical assay performance was characterized according to CLSI guidelines. Precision evaluation using a panel of CSF sample preparations resulted in total CV ≤8% for both Lumipulse G β-Amyloid 1-42 and Total Tau assays. The LoD and LoQ for the Lumipulse G β-Amyloid 1-42 and Total Tau assays were shown to be <10 pg/mL and <15 pg/mL, and <40 pg/mL and <60 pg/mL, respectively. No high dose hook effect was observed for samples containing up to 200.000 pg/mL of Aβ1-42 and total tau protein, respectively. Linearity was shown across the clinical application range for both assays. In a method comparison study with the routinely used INNOTEST β-AMYLOID(1-42) and INNOTEST hTAU Ag assays, good correlation (r>0.90) was demonstrated. In addition, a good correlation to the recently approved reference measurement procedure (RMP) for Aβ1-42was shown. Automation, the mono test cartridge principle, short reaction times and instrument flexibility are key attributes of the LUMIPULSE G instrument series making it the ideal platform to fulfill today’s needs for rapid and accurate quantification of CSF biomarkers in both low and high throughput clinical laboratories. The novel Aβ1-42 and total tau assays on the LUMIPULSE G instruments show good sensitivity and precision and correlate well with the established INNOTEST assays and the RMP for Aβ1-42.
A multi-FPGA high performance computing platform for network-centric applications (2006)

The current network technologies and market are pushing the envelope for high-performance computing power at the edge of the network. One such technology support for this computational power is the on-the-field reconfigurable technologies. In this paper we present an overview of a highly-parallel Field Programmable Gate Array (FPGA) system architecture called Super Reconfigurable Fabric Architecture (SuRFA) that combines fine-grain FPGA architecture with coarse-grain Single Instruction Multiple Data (SIMD) parallel processing cells (SPEC). We have demonstrated a multi-FPGA based virtual SuRFA implementation for building a fabric architecture that can support vast number of network-centric applications.
THE ROLE OF THE NUCLEAR MATRIX IN THE ORGANIZATION AND FUNCTION OF DNA (1986)

CONTENTS PERSPECTIVES AND OVERVIEW .......•...••...•.........•.•.........•.....•....• •• • •....• •....•• 457 THE NUCLEAR MATRIX ORGANIZES DNA INTO LOOP-DOMAINS 462 DNA LOOP-DOMAINS AND A MODEL FOR CHROMOSOME STRUCTURE 463 DNA TOPOISOMERASES ASSOCIATED WITH THE NUCLEAR MATRIX 466
Effect of Hierarchical Scaffold Consisting of Aligned dECM Nanofibers and Poly(lactide-co-glycolide) Struts on the Orientation and Maturation of Human Muscle Progenitor Cells (2019)

Extracellular matrices (ECMs) derived from tissues and decellularized are widely used as biomaterials in tissue engineering applications because they encompass tissue-specific biological and physical cues. In this study, we utilized a solubilized decellularized tissue (dECM) obtained from skeletal muscle to fabricate a nanofibrous structure using the electrospinning technique. The dECM was chemically modified by methacrylate reaction (dECM-MA) to improve the structural stability before electrospinning. The electrospun dECM-MA nanofibers were combined with microscale fibrillated poly(lactide-<i>co</i>-glycolide) (PLGA) constructs fabricated by three-dimensional printing and fibrillation/leaching of poly(vinyl alcohol) to promote skeletal muscle cell orientation and maturation. Using the electrostatic force-assisted fiber-alignment method, a multiscale composite scaffold consisting of fibrillated PLGA and aligned dECM-MA nanofibers was fabricated. The multiscale dECM-MA/PLGA composite scaffold significantly promoted the cellular orientation and myotube formation of human muscle progenitor cells compared to control scaffolds. The results suggested the potential use of the multiscale dECM-MA/PLGA composite scaffold, which contains the biochemical and topographical cues, for bioengineering a skeletal muscle tissue construct.
(Invited) Single Walled Carbon Nanotube (SWNT) Atomic Structure and Thin Film Color during the Floating Catalyst Chemical Vapor Deposition (FC-CVD) Synthesis (2022)

We discuss the FC-CVD synthesis of SWNTs, especially the tuning of tube atomic structure i.e. (n,m) distributions and subsequently the thin film color. By introducing various amount of CO 2 with CO as the carbon source and in-situ ferrocene decomposition generated Fe catalyst nanoparticles, we directly produced SWNT films with tunable (n,m) i.e. helicity distribution as well as tunable colors. When operating the FC-CVD reactor at the ambient pressure and at 850 o C temperature with 0.25 and 0.37 volume percent of added CO 2 , the SWNT films display green and brown colors, respectively. We ascribed various colors to suitable diameter and narrow (n,m) distributions, which were determined in detail using the electron diffraction. We calculate the color maps for all SWNT (n,m) structures. N. Wei et al. Adv. Mater . 2021, 33, 2006395.
Gold Microshell Tip for In Situ Electrochemical Raman Spectroscopy (2011)

Tip fabrication by a new strategy is proposed for simultaneous acquisition of electrochemical (EC) signals from an ultramicroelectrode and spectroscopic information from surface-enhanced Raman scattering (SERS). The EC-SERS tip is prepared by carefully tuning a SERS-active gold microshell to maximize Raman scattering, mechanically attaching it to the end of a micropipet, and electrically connecting it to a ruthenium inner layer through electroless deposition.
Chiral Smectics: Molecular Design and Superstructures (2005)

ABSTRACT Molecular design producing a strong chiral effect has been proposed and dichiral twin and monomeric materials have been prepared systematically based on this concept. A variety of superstructures are generated in the chiral smectic phases, including ferrielectric and antiferroelectric phases, a twist grain boundary phase and the variants, such as smectic blue and smectic Q phases, and mysterious isotropic phases exhibiting an anomalous electric-field induced phase transition.