gebhart/patrepeval huggingface dataset:
Carbon−Carbon Bond Formation from Small- and Medium-Ring Lactol Acetates via Radical and Oxonium Ion Intermediates. Synthesis of (±)-Laurenan (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCarbon−Carbon Bond Formation from Small- and Medium-Ring Lactol Acetates via Radical and Oxonium Ion Intermediates. Synthesis of (±)-LaurenanScott D. Rychnovsky and Vilas H. DahanukarView Author Information Department of Chemistry, University of California, Irvine, California 92697-2025 Cite this: J. Org. Chem. 1996, 61, 22, 7648–7649Publication Date (Web):November 1, 1996Publication History Received30 July 1996Published online1 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo9614349https://doi.org/10.1021/jo9614349rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1186Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Mixtures,Organic compounds,Post-translational modification,Selectivity Get e-Alerts
FeFe hydrogenase reductive inactivation and implication for catalysis (2013)

We show that FeFe hydrogenases inactivate at low potential, in a complex process that is mostly reversible. A form of the enzyme that is produced slowly and reversibly under reductive conditions has no proton activity under reductive conditions, although it can still oxidize H2 under oxidative conditions. This suggests that the so-called “super-reduced” state of the active site H-cluster is not part of the normal catalytic cycle. We also discuss our findings in relation to the optimization of H2-photoproduction devices based on FeFe hydrogenases that receive electrons from low potential photosensitizers.
3-LB: Golimumab (GLM) Preserves ß-Cell Function and Reduces Insulin Use and Hypoglycemia in Children and Young Adults with Recently Diagnosed Type 1 Diabetes (T1D): The Phase 2 T1GER Study (2020)

T1D is an autoimmune disease characterized by progressive loss of pancreatic β cells. GLM is a human IgG1κ monoclonal antibody specific for tumor necrosis factor α. This study assessed whether GLM preserves β-cell function in children and young adults with newly diagnosed stage 3 T1D. This Phase 2a, double-blind, placebo (PBO)-controlled study randomized participants aged 6-21 yrs with newly diagnosed stage 3 T1D to receive subcutaneous GLM (BSA-based dose if &amp;lt;45 kg; fixed dose if ≥45 kg) or PBO (2:1) for 52 weeks. The primary endpoint was C-peptide area under the curve (AUC) at Week 52 after a 4-hour mixed-meal tolerance test. Insulin use, HbA1c, hypoglycemia rates, and proinsulin/C-peptide ratios were assessed. 84 participants were enrolled (GLM, n = 56; PBO, n = 28). The study was positive as mean (SD) 4-hour C-peptide AUC at Week 52 was 0.64 (0.423) and 0.43 (0.388) pmol/mL with GLM and PBO, respectively (P&amp;lt;0.001; Figure). GLM-treated participants had lower insulin use, hypoglycemia rates, and proinsulin/C-peptide ratios vs. PBO. Both groups maintained good glycemic control. GLM was well tolerated, without any new safety signals. In this study, golimumab demonstrated the ability to preserve endogenous insulin production and improve clinical and metabolic parameters in children and young adults with newly diagnosed stage 3 T1D. Disclosure T. Quattrin: Consultant; Self; Janssen Pharmaceuticals, Inc. Research Support; Self; Janssen Pharmaceuticals, Inc., Provention Bio, Inc. M.J. Haller: Advisory Panel; Self; SAB Biotherapeutics, Inc. A. Steck: None. E. Felner: None. Y. Li: Employee; Self; Janssen Research &amp; Development, LLC. K. Xia: Employee; Self; Janssen Research &amp; Development, LLC. J. Leu: Employee; Self; Janssen Research &amp; Development, LLC. M. Rigby: None. R. Zoka: Employee; Self; Janssen Research &amp; Development, LLC. J. Hedrick: Employee; Self; Janssen Pharmaceuticals, Inc. F. Vercruysse: Employee; Self; Janssen Pharmaceuticals, Inc. Stock/Shareholder; Self; Johnson &amp; Johnson. Funding Janssen Research &amp; Development, LLC
Spectroscopic and Photochemical Properties of Open-Chain Carotenoids (2002)

The spectroscopic properties of open-chain, all-trans-C30 carotenoids having seven, eight and nine π-electron conjugated carbon−carbon double bonds were studied using steady-state absorption, fluorescence, fluorescence excitation and time-resolved absorption spectroscopy. These diapocarotenes were purified by high performance liquid chromatography (HPLC) prior to the spectroscopic experiments. The fluorescence data show a systematic crossover from dominant S1 → S0 (21Ag → 11Ag) emission to dominant S2 → S0 (11Bu → 11Ag) with increasing extent of conjugation. The low temperatures facilitated the determination of the spectral origins of the S1 → S0 (21Ag → 11Ag) emissions, which were assigned by Gaussian deconvolution of the experimental line shapes. The lifetimes of the S1 states of the molecules were measured by transient absorption spectroscopy and were found to decrease as the conjugated chain length increases. The energy gap law for radiationless transitions is used to correlate the S1 energies with the dynamics. These molecules provide a systematic series for understanding the structural features that control the photochemical properties of open-chain, diapocarotenoids. The implications of these results on the roles of carotenoids in photosynthetic organisms are discussed.
A prototype of landmark-based car navigation using a full-windshield head-up display system (2009)

In driving applications, a full windshield head-up display (FWD) system provides a flexible way for delivering driving related information. The projected information (text, image and graphics) is distorted on the car windshield because of its non-planar surface, the FWD projector's position and the viewing angle of the driver. In this paper, we present development of a prototype of landmark-based car navigation using an FWD system. We propose to use a computer vision method to automatically correct FWD projection distortion on the windshield. Our system consists of an FWD, a camera and an LCD video projector. In the calibration phase, the camera captures the patterns projected by the FWD projector and our method automatically models the windshield distortion. In the working phase, the LCD video projector projects a video sequence (that is captured on a moving vehicle in the real driving situation) onto a wall to simulate real driving and the camera simulates the driver's view. Our system aims to detect and highlight key landmarks such as road signs on the windshield by controlling the FWD projector to provide better navigation information. We demonstrate the proposed concept using our previously developed street landmark detection system.
Solving Electromagnetic Wave Equations with Time Varying Characteristics Curves (2022)

When multiple temporal boundaries exist in a temporal system, the characteristic curves of the associated wave equations vary with time. We show that these types of problems can be readily addressed by dividing the entire time frame into several durations and repeatedly applying the d’Alembert formula.
All-solution-processed, flexible thin-film transistor based on PANI/PETA as gate/gate insulator (2015)

An all-solution processed flexible thin-film transistor based on a PANI/PETA gate/gate insulator exhibited higher mobility than the device with a Si/SiO<sub>2</sub> gate/gate insulator because of large crystalline domains in the transition region.
Human Alertness Optimization with a Three-Process Dynamic Model (2022)

Circadian rhythm is an important biological process for humans as it modulates a wide range of physiological processes, including body temperature, sleep-wake cycle, and cognitive performance. As the most powerful external stimulus of circadian rhythm, light has been studied as a zeitgeber to regulate the circadian phase and sleep. This paper addresses the human alertness optimization problem, by optimizing light exposure and sleep schedules to relieve fatigue and cognitive impairment, in cases of night-shift workers and subjects with certain mission periods based on dynamics of the circadian rhythm system. A three-process hybrid dynamic model is used for simulating the circadian rhythm and predicting subjective alertness and sleepiness. Based on interindividual difference in sleep type and living habits, we propose a tunable sleep schedule in the alertness optimization problem, which allows the appropriate tuning of sleep and wake times based on sleep propensity. Variational calculus is applied to evaluate the impacts of light and sleep schedules on the alertness and a gradient descent algorithm is proposed to determine the optimal solutions to maximize the alertness level in various cases. Numerical simulation results demonstrate that the cognitive performance during certain periods can be significantly improved by optimizing the light input and tuning sleep/wake times compared to empirical data.
Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of α v β 3 - antagonists in rat: limited role of P-glycoprotein (2002)

1. The study investigated mechanisms underlying the pharmacokinetic differences of two zwitterionic diastereomers ((3S)-3-[(3R or 3S)-2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]pyrrolidin-1-yl]-3-quinolin-3-ylpropanoic acid) with different lipophilicities using a combination of in vivo and in vitro approaches. 2. In rat, both isomers possessed comparable plasma clearances (CL). However, the more lipophilic diastereomer I exhibited a higher metabolic clearance (>2-fold higher than II), whereas the hydrophilic zwitterion II exhibited a higher biliary clearance (approximately 5-fold higher than I). Following oral administration, the bioavailability (F) of I (17%) was much higher than that of II (1%). 3. Consistent with these in vivo observations and the expectation based on their lipophilicity differences, the metabolism in rat liver microsomes was faster and the permeability in Caco-2 and LLC-PK1 cells and in situ rat intestinal loop was better for I than for II. 4. Only the absorption of the more lipophilic diastereomer I was subjected to an efflux system in the Caco-2 and in situ rat intestinal loop models. I was a good substrate for P-glycoprotein (P-gp) in both the human MDR1 and mouse mdr1a transfected cell lines, and in the wild-type mdr1a (-/-) mouse when compared with the P-gp-deficient mdr1a (-/-) mouse. Concomitant administration of I with verapamil in rat caused significant increases in oral AUC, F and Cmax of I without affecting its CL, further supporting the effect of P-gp in limiting the intestinal absorption of I in vivo in this animal model. 5. Since the findings that the lipophilic diastereomer I, but not II, was a good P-gp substrate were not in line with the observations that I was excreted to bile much slower than II and that I was absorbed better than II, the results suggested that P-gp played a minor role to the observed differences in the biliary excretion and intestinal absorption of the diastereomers I and II in rat.
Frequency-stabilized W-band two-tone optical signal generation for high-speed RoF and radio transmission (2011)

We demonstrated W-band RoF signal generation with high-extinction-ratio optical modulation. Frequency quadruple technique with optical band elimination filter realizes frequency-stabilized W-band two-tone optical signal generation and its separation by AWG.
Converted Wave Imaging Using VSP Data – Looking up from an Extended-reach Horizontal Well (2009)

We show how, using an offset source and an array of 3-component receivers deployed in a well bore, one may produce an image of acoustic interfaces located between the source and the receivers. The new method detects the polarization and signature of the d
Optical waveguide fabrication in new glasses and PMMA with temporally tailored ultrashort laser (2004)

We have comparatively studied waveguide fabrication characteristics in various transparent materials by use of temporally shaped femtosecond laser pulses. The materials which we studied here are fused quartz, K-PG375 glass whose melting point is as low as 648 K, and polymethylmethacrylate (PMMA). We have measured amount of refractive index change, writing speed, and laser fluence threshold for waveguide writing in the above mentioned materials. To optimize the optical quality of internal modification of transparent materials by femtosecond laser pulses, we controlled the free electron density induced in the materials by tailoring energy injection as a function of time.
Mucin Biopolymers Prevent Bacterial Aggregation by Retaining Cells in the Free-Swimming State (2012)

Many species of bacteria form surface-attached communities known as biofilms. Surrounded in secreted polymers, these aggregates are difficult both to prevent and eradicate, posing problems for medicine and industry. Humans play host to hundreds of trillions of microbes that live adjacent to our epithelia, and we are typically able to prevent harmful colonization. Mucus, the hydrogel overlying all wet epithelia in the body, can prevent bacterial contact with the underlying tissue. The digestive tract, for example, is lined by a firmly adherent mucus layer that is typically devoid of bacteria, followed by a second, loosely adherent layer that contains numerous bacteria. Here, we investigate the role of mucus as a principle arena for host-microbe interactions. Using defined in vitro assays, we found that mucin biopolymers, the main functional constituents of mucus, promote the motility of planktonic bacteria and prevent their adhesion to underlying surfaces. The deletion of motility genes, however, allows Pseudomonas aeruginosa to overcome the dispersive effects of mucus and form suspended antibiotic-resistant flocs, which mirror the clustered morphology of immotile natural isolates found in the cystic fibrosis lung mucus. Mucus may offer new strategies to target bacterial virulence, such as the design of antibiofilm coatings for implants.
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer (2001)

Cationic lipid-mediated gene transfer efficiency increased when cells underwent mitosis. However, when cells did not divide, gene transfer was not completely abolished. Nuclear import of plasmid was greatly facilitated by a mitotic event. In non-mitotic cells, nuclear envelope crossing by plasmid DNA could be detected but was a very rare event.
X-ray multisource for medical imaging (2009)

This paper presents a progress update with the development of a distributed x-ray source. We present a high level
summary of the source integration, simulation and experimental results, as well as challenges in electron beam focusing,
beam current gating, voltage isolation, and anode technologies. We present focal spot measurements, x-ray images and
a summary of our distributed x-ray source concept.
Biosynthetic basis of incompatible histo-blood group A antigen expression: anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals. (1993)

The expression of incompatible A carbohydrate antigens in some adenocarcinomas may provide an explanation for the generally observed lower incidence of adenocarcinoma among types O and B versus type A individuals. The chemistry and genetic basis of incompatible A expression is largely unknown. Here, we have screened 31 cases of gastric tumors of phenotype O for the expression of blood group A gene-defined glycosyltransferase by immunohistology on frozen sections using newly developed monoclonal antibodies to the transferases. Three cases were positive, and transferase expression was confirmed by enzyme analysis of extracts from the specimens. Blood group A carbohydrate antigens were also identified immunohistologically in these three cases as well as in five other cases. Thin-layer chromatography immunostaining analysis of glycolipid extracts from the three cases did not confirm the chemical presence of A antigen. The ABO genotype of all patients was found to be OO, showing that all carried O alleles with a structural defect at nucleotide position 261 leading to a shift in the reading frame. The data suggest that incompatible A antigen expression is a result of transferase expression derived from the ABO genes.
Micromechanical Structures for Fracture Testing of Brittle Thin Films (1996)

Abstract A new structure for determining the fracture characteristics of brittle thin films has been designed, fabricated and tested. The structure consists of a rigid central shuttle to which are attached a number of cantilever beams of varying lengths which will provide the desired fracture information. The central shuttle is tethered to the substrate by flexible beams which allow it to be moved controllably in one direction while the free ends of the cantilevers are prevented from movement by stops. By measuring the shuttle displacement at which the various beams fail, the failure strain of the beam material is determined. This structure design has been used to examine the fracture characteristics of a particular LPCVD polycrystalline silicon film, and the degradation in strength which occurs with exposure to hydrofluoric acid. The average strain at fracture measured for this heavily phosphorus doped polycrystalline silicon was 1.1% for a 10 minute exposure to hydrofluoric acid. This value drops to 0.84% after the material is exposed to hydrofluoric acid for 2 hours.
Ophthalmologic features of the common spinocerebellar ataxias (2010)

The ophthalmologist may be the first to encounter a patient with SCA, and a review of the most common genetic subtypes of this disorder is helpful in diagnosis and management.
Mecanismes de synchronisation dans un gerant d'objets distribue base sur des charpentes (1996)

Aujourd'hui, l'architecture des systemes de gestion de bases de donnees objets, leurs mecanismes de controle de concurrence classique et leurs mecanismes de gestion de transcations restreignent l'utilisation de ces systemes a des groupes de travail limites. Cette these presente un ensemble de techniques permettant de circonvenir a ces limitations afin d'elargir le domaine d'utilisation des bases de donnees objets. Les systemes de gestion de bases de donnees objets doivent devenir des composants completement integres dans les systemes d'exploitation distribues. Le systeme presente dans cette these permet de gerer la persistance des objets, le controle des acces concurrents et assure la coherence globale des manipulations au travers de mecanismes de gestion de transaction evolues. Tous ces services se presentent sous la forme de charpentes objets completement adaptables par le concepteur d'applications distribuees. Le systeme de gestion de la persistance, appelee charpente de persistance, gere des bases locales d'objets persistants. Ces objets sont exprimes dans un modele neutre d'objets, rendant ces bases d'objets accessibles au travers de divers langages. La charpente de persistance est construite autour de quelques concepts simples, les conteneurs, qui stockent des objets, et les identificateurs qui permettent de retrouver ces objets dans les conteneurs. Elle permet a l'utilisateur de developper ses propres conteneurs. Elle peut etre utilisee seule pour construire des applications monolithiques n'ayant que des besoins de persistance permettant a l'application de ne pas payer le surcout lie aux mecanismes transactionnels. Afin de partager des objets, l'utilisateur utilise la charpente transactionnelle. Celle-ci prend en charge la distribution des objets, le controle des acces concurrents ainsi que la coherence globale du systeme au travers de la gestion de transactions. Cette charpente est basee sur un modele etendu de transactions emboitees permettant de definir de nouveaux types de transactions tout en assurant la coherence globale de la base. La coherence est basee sur un protocole de verrouillage permettant a la fois d'augmenter la concurrence entre transactions mais aussi de definir un mecanisme de journalisation performant. Sur la base de ces charpentes, un ensemble de mecanismes et d'extensions du modele de transactions est presente afin de construire des applications cooperatives sychrones. Ces outils cooperatifs vont de mecanismes de notification a l'introduction de transactions cooperatives.
Hierarchical Cooperation and Load Balancing for Scalable Autonomous Vehicle Routing in Multi-Access Edge Computing Environment (2023)

When Connected Autonomous Vehicles (CAVs) request routing in a driving environment with Autonomous Intersection Management (AIM) systems, a routing planner collects the demands and optimizes the routes in a coordinated manner to reduce the overall travel times. In practice, however, the routing demands are massive, especially in a large-scale traffic network. As a result, the centralized routing planner fails to scale out to accommodate the growing requests, causing a severe scalability issue. This paper presents a holistic solution for scalable CAV routing by enabling hierarchical cooperation and load balancing in the Multi-Access Edge Computing (MEC) environment. The proposed system cooperatively plans CAV routes and dynamically balances loads in MECs to handle massive requests. According to the experiments, our system has a 15.68X higher routing capacity than the centralized routing system, and load balancing reduces 14.51% computation time of routing. The experiments show that our system is scalable for massive autonomous vehicle routing.
Improvement in the Azimuthal EM Method — The Value of Signal Processing (1998)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 1998Improvement in the Azimuthal EM Method — The Value of Signal ProcessingAuthors: Lee SlaterStewart SandbergMariusz JankowskiLee SlaterDept. of Geosciences, University of S. Maine, Gorham, ME04038, Stewart SandbergDept. of Geosciences, University of S. Maine, Gorham, ME04038, and Mariusz JankowskiDept. of Electrical Engineering, University of S. Maine, Gorham, ME04038https://doi.org/10.4133/1.2922500 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2922500FiguresReferencesRelatedDetails Symposium on the Application of Geophysics to Engineering and Environmental Problems 1998ISSN (online):1554-8015Copyright: 1998 Pages: 1071 publication data© 1998 Copyright © 1998 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished Online: 30 Sep 2008 CITATION INFORMATION Lee Slater, Stewart Sandberg, and Mariusz Jankowski, (1998), "Improvement in the Azimuthal EM Method — The Value of Signal Processing," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : 177-186. https://doi.org/10.4133/1.2922500 Plain-Language Summary PDF DownloadLoading ...