gebhart/patrepeval huggingface dataset:
Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis (2014)

Prostate cancer (PCa) has been cited as the second leading cause of cancer-related death in American men and its morbidity/mortality has increased globally in recent years. The high mortality rate is closely associated with the spread of malignant cells to various tissues especially to bone. Nearly 10% of patients whose conditions are diagnosed as PCa clinically present with bone metastasis and almost all patients who die of prostate cancer have skeletal involvement. Identifying new mechanisms that control bone metastasis is of great consequence to facilitate the design of therapeutics aimed at decreasing metastatic risk and/or resulting secondary complications. We completed an interrogation of the Molecular Libraries Small Molecule Repository (MLSMR) for antagonists of the CXCR6 receptor in cell-based functional assay. Here, we report for the first time a novel potent (140 nM IC50) small molecule CXCR6 antagonist that is selective (>79 μM IC50) against CXCR5, CXCR4, CCR6 and APJ receptors. It is non-promiscuous against 23 other G protein-coupled receptors (GPCRs), showing only moderate activity against 5-HT2B and DAT at 10 μM in competitive binding assays. This probe will assist in addressing a key hypothesis that the CXCR6/CXCL16 axis significantly contributes to PCa cell metastasis, proliferation and subsequent bone invasion. A small molecule antagonist would block cancer cell trafficking; hence mediate a metastatic event and disease progression. Access to pharmacologically available small molecule antagonists will ultimately enable our targeted studies in disease relevant models and allow for a more seamless translational advancement toward clinical applications.
Intelligent hierarchical thrust vector control for a space shuttle (1994)

We present the design of a thrust vector controller for a space shuttle vehicle with multiple engines. This controller will maintain vehicle trajectory and thrust vector while minimizing risk and damage to each engine and to the propulsion system as a whole by independently controlling the thrust magnitude and exhaust cone gimbals angles of each engine. A statistical model from reliability theory is used to estimate overall engine damage accumulation and failure risk. An intelligent control system framework which functionally decomposes the control task into a formal hierarchical structure composed of nominally independent task coordinators is used to design and analyze the control structure for the entire propulsion system. One subtask that appears repeatedly within the hierarchy is that of distributing the required control actions among multiple engines or actuators dynamically in response to changing damage, risk, and status information. We identify this as the "control relegation problem" and solve it using linear quadratic optimal control techniques with variable weighting matrices. The individual controllers, when integrated into the formal structure, achieve the control objectives while minimizing mission risk and component stress and maximizing operating efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction (2012)

Our data suggest that PATE protein is involved in sperm-oolemma fusion and penetration but not sperm-zona binding.
SPECT Imaging of Inflammatory Response in Ischemic–Reperfused Rat Hearts Using a 99mTc-Labeled Dual-Domain Cytokine Ligand (2013)

The dual-domain TFI is promising for noninvasive detection of inflammatory reactions in IR myocardium because of its more potent affinity to the inflammatory sites compared with TF and IF.
Multimodal Sensor System for Pressure Ulcer Wound Assessment and Care (2017)

We present a multimodal sensor system for wound assessment and pressure ulcer care. Multiple imaging modalities including RGB, three- dimensional (3-D) depth, thermal, multispectral, and chemical sensing are integrated into a portable hand-held probe for real-time wound assessment. Analytic and quantitative algorithms for various assessments including tissue composition, wound measurement in 3-D, temperature profiling, spectral, and chemical vapor analysis are developed. After each assessment scan, 3-D models of the wound are generated on the fly for geometric measurement, while multimodal observations are analyzed to estimate healing progress. Collaboration between developers and clinical practitioners was conducted at the Charlie Norwood VA Medical Center for in-field data collection and experimental evaluation. A total of 133 assessment sessions from 23 enrolled subjects were collected, on which the multimodal data were analyzed and validated with respect to clinical notes associated with each subject. The system can be operated by nontechnical caregivers on a regular basis to aid wound assessment and care. A web portal front-end was developed for clinical decision and telehealth support, where all historical patient data including wound measurements and analysis can be organized online.
Preventive Treatment for Enhancing Water Removal From Gas Reservoirs by Wettability Alteration (2007)

Abstract Water blocks and condensate drop out near the wellbore in a gas reservoir can cause rapid production decline. The liquid (water/condensate) is trapped near the wellbore due to strong capillary forces and/or viscous fingering of gas through the liquid. To remove this liquid, alcoholic solvents are injected into the near wellbore area; however, this remedial solution needs to be reapplied in case of any subsequent water or condensate banking in the well. In this paper, we present a preventive and permanent chemical treatment for the removal of water and condensate blocks. Three types of tests have been conducted to evaluate the performance of the chemical system which include contact angle, imbibition and core flow test. A total of 41 chemicals have been tested using contact angle and imbibition tests and only 2 chemicals, A5 and A6 were selected for core flow test as they were stable at high temperature and did not damage the cores excessively during the imbibition tests. The core treated with a solution containing 5% A5 and 95% brine (2-wt% KCl) in the core flow test gave higher clean up of trapped water due to reduction in capillary force. This treatment system also shows a better alteration of the formation wettability from liquid wet to non-liquid wet conditions compared to the other chemical systems tested.
Efficient High Area OFETs by Solution Based Processing of a π-Electron Rich Donor (2006)

We report on the preparation of high performance field-effect transistors (FETs) based on large areas of aligned films of a TTF derivative, namely, tetrakis-(octadecylthio)-tetrathiafulvalene (TTF-4SC18). TTF-4SC18 assembles into one-dimensional stacks in which the long alkyl chains promote intermolecular π−π overlapping due to their extremely closely packed nature. The films were prepared from solution by zone-casting, a simple technique that does not require the use of preoriented substrates. The films were characterized by AFM and X-ray, indicating an extremely high crystalline quality. The TTF molecules are tilted with respect to the substrate surface and are well-aligned in the casting direction. More than 40 FETs were measured, showing a remarkable reproducibility of their performance. The average charge carrier mobility value measured along the casting direction was about 0.006 cm2/V s for a channel length L = 100 μm and about 0.01 cm2/V s for L = 80 μm and L = 50 μm. The FET mobilities determined in the direction perpendicular to the orientation were ca. 1 order of magnitude lower. We found that all the devices after annealing exhibited an enhanced performance with FETs mobilities about 1 order of magnitude higher. The best devices revealed a charge carrier mobility close to 0.1 cm2/V s with an on/off ratio of the order of 104.
Correction: Manipulation of cell adhesion and dynamics using RGD functionalized polymers (2017)

Correction for 'Manipulation of cell adhesion and dynamics using RGD functionalized polymers' by Juyi Li et al., J. Mater. Chem. B, 2017, DOI: .
A study on nanofiber‐reinforced thermoplastic composites (II): Investigation of the mixing rheology and conduction properties (2001)

Abstract This article is portion of a comprehensive study on the development of nanofiber‐reinforced polymer composites for electrostatic discharge materials and structural composites. Vapor‐grown carbon fibers with an average diameter of 100 nm were used as a precursor and model fiber system for carbon nanotubes. These nanofibers were purified and functionalized to provide for an open network of high‐purity nanofibers. Banbury‐type mixing was used to disperse the nanofibers in the polymer matrix. Rheological and microscopic analysis showed that the high shear processing of the polymer/nanofiber mixture led to a homogeneous dispersion of nanofibers with no agglomerates present and no shortening of the nanofibers. The shear thinning behavior of polymeric materials helps in the mixing of the nanofibers to form the composites. A percolation threshold for electrical conduction of 9–18 wt % was observed for the highly dispersed nanofiber networks. The electrical behavior of these materials was not affected by changes in humidity. Microscopic analysis showed highly dispersed nanofibers with no indications of porosity. These conducting polymers are well suited for electrostatic discharge applications, and might well become multifunctional materials for strength/electrical applications. © 2001 John Wiley &amp; Sons, Inc. J Appl Polym Sci 80: 1162–1172, 2001
High fibre coupled output power 37 nm tunable laser module using matrix DFB laser (2003)

The thermally-controlled laser module, integrating 12 distributed feedback (DFB) lasers in the form of a 2×6 matrix to realise both high output power and wide wavelength tunability, has been fabricated. The module has shown excellent characteristics, such as high fibre coupled power over 30 mW and tunability over 37 nm.
Experimental Evidence for an Attractive p−ϕ Interaction (2021)

This Letter presents the first experimental evidence of the attractive strong interaction between a proton and a ϕ meson. The result is obtained from two-particle correlations of combined p-ϕ⊕ p[over ¯]-ϕ pairs measured in high-multiplicity pp collisions at sqrt[s]=13 TeV by the ALICE Collaboration. The spin-averaged scattering length and effective range of the p-ϕ interaction are extracted from the fully corrected correlation function employing the Lednický-Lyuboshits approach. In particular, the imaginary part of the scattering length vanishes within uncertainties, indicating that inelastic processes do not play a prominent role for the p-ϕ interaction. These data demonstrate that the interaction is dominated by elastic p-ϕ scattering. Furthermore, an analysis employing phenomenological Gaussian- and Yukawa-type potentials is conducted. Under the assumption of the latter, the N-ϕ coupling constant is found to be g_{N-ϕ}=0.14±0.03(stat)±0.02(syst). This work provides valuable experimental input to accomplish a self-consistent description of the N-ϕ interaction, which is particularly relevant for the more fundamental studies on partial restoration of chiral symmetry in nuclear medium.
Control of α/β Anomer Formation by a 2′,5′ Bridge: Toward Nucleoside Derivatives Locked in the South Conformation (2017)

We describe a novel stereoselective synthesis of nucleoside derivatives with the ribose ring locked in the South conformation by a bridge between C2' and C5'. Despite the intrinsic constraints of the bicyclic structure, we demonstrate that their synthesis can be achieved by ring closing metathesis of readily accessible precursors. The obtained ribose derivatives are, however, very poor substrates for further installation of the nucleobases, and even simple nucleophiles, such as azido or cyano anions, react with unexpected stereo- or regioselectivity under standard glycosylation conditions. Here we explain this behavior by employing density functional theory (DFT) computations and devise an alternative approach resulting in isomers with the desired orientation of the nucleobase.
A Fast Implementation of Matrix-matrix Product in Double-double Precision on NVIDIA C2050 and Application to Semidefinite Programming (2012)

We have implemented a fast double-double precision (has approx. 32 decimal significant digits) version of matrix-matrix multiplication routine called "Rgemm" of MPACK (http://mplapack.sourceforge.net/) on NVIDIA C2050 GPU. This routine is a higher precision version of gdgemmh in the BLAS (Basic Linear Algebra Subprograms) library. Our implementation is the fastest to date using NVIDIA C2050 and most efficient on NVIDIA GPUs, we achieved the peak performances of 16.4GFlops for the kernel performance (16.1GFlops with CPU-GPU transfer included), and 26.4GFlops (25.7GFlops with CPU-GPU transfer included) by employing lower accuracy arithmetic. These are 92.3% (90.7%) and 87.1% (84.8%) of the theoretical peak performance of NVIDIA C2050, which is about 150 times faster than the reference implementation on Intel Xeon X3470. Moreover, our implementations can handle arbitrary sizes of matrices by employing gPointer redirectingh technique by Nath et al. We integrated this GPU-accelerated version of Rgemm for double-double precision version of semi definite programming solver called SDPA-DD, and the performance improved at most 14.5 times. This version of Rgemm is available at http://mplapack.sourceforge.net/ since 2011/10/28.
Merit of PHY-MAC Cross-Layer Carrier Sensing: A MAC-Address-based Physical Carrier Sensing Scheme for Solving Hidden-Node and Exposed-Node Problems in Large-Scale Wi-Fi Networks (2006)

This paper examines how various carrier-sensing schemes affect the exposed-node (EN) and hidden-node (HN) phenomena. In the process, we identify a new carrier-sensing mechanism for alleviating EN and HN that is more effective than previously proposed schemes. This scheme, referred to as the MP scheme, uses MAC-address-based Physical carrier sensing to determine if the medium is busy. In MP, the addresses of transmitter and receiver of a packet are incorporated into the PHY header. Making use of this address information for its carrier-sensing operation, a node can drastically reduce the detrimental effects of EN and HN. In ns2 simulations, MP yields superior throughput and fairness performance that exceed our original expectation. Specifically, we find that the total network throughput achieved by MP is more than twice that of the 802.11b basic-access mode, and more than four times that of the 802.11b RTS/CTS mode, under various node-density and packet-size assumptions. At the same time, the Jains fairness index of MP is almost twice that of the 802.11b basic-access and RTS/CTS modes. We believe this is a first paper to propose and investigate the merit of cross-layer carrier sensing that jointly makes use of the attributes of the physical and MAC layers in its operation
Effect of directivity on estimates of radiated seismic energy (2004)

To accurately estimate the seismic energy radiated in an earthquake, it is important to use appropriate corrections for path and source effects. Using slip models obtained by inversion of seismic data, we examine the effect of directivity on estimates of radiated energy and develop a method to correct for this source effect. From our calculations we suggest that the directivity correction for the earthquakes we studied is less than a factor of three; we also conclude that the directivity correction for dip‐slip earthquakes with rupture propagating along strike is less than a factor of two at teleseismic distances. Thus teleseismic energy estimates of large subduction zone earthquakes will not be significantly affected by directivity.
High-performance logic circuits using solution-based, low-temperature semiconductors for flexible electronics (2013)

In this work we demonstrate high performance and low-power n-type inverters using solution-based CdS as the semiconductor in thin film transistors. Our fabrication process consists of five mask levels and a maximum temperature of 150 &deg;C. The CdS is deposited using chemical bath deposition at 70 &deg;C to provide full compatibility with flexible substrates. Isolated TFTs showed mobilities up to 10 cm<sup>2</sup>/V-s and threshold voltages of approximately 0.5V. Inverters were biased at 1, 3 and 5 V, resulting in maximum gains in the range of 60 at V<sub>DD</sub> = 3V. The devices and circuits are fully patterned using standard photolithographic techniques that can be used to design more complex circuitry for flexible and large area electronic applications. In addition we used an extraction parameter method for our TFTs that allows the use of regular SPICE simulation software to design and test the circuits. Our simulations are in good agreement with the experimental data for isolated devices and inverters. Other circuits such as NAND gates are also demonstrated.
κ+λ+ dual receptor B cells are present in the human peripheral repertoire. (1995)

It is a common notion that mature B lymphocytes express either kappa or lambda light (L) chains, although the mechanism that leads to such isotypic exclusion is still debated. We have investigated the extent of L chain isotypic exclusion in normal human peripheral blood B lymphocytes. By three-color staining with anti-CD19, anti-kappa, and anti-lambda antibodies we could estimate that 0.2-0.5% of peripheral blood B cells from healthy adults express both kappa and lambda on the cell surface. The kappa+lambda+ cells were sorted, immortalized by Epstein-Barr virus, and five independent clones were characterized in detail. All clones express both kappa and lambda on the cell surface and produce immunoglobulin M that contain both kappa and lambda chains in the same molecule, i.e., hybrid antibodies. Sequencing of the L chains revealed in three out of five clones evidence for somatic mutations. It is interesting to note that among a panel of single receptor B cell clones we identified two lambda+ clones that carried a productively rearranged kappa, which was inactivated by a stop codon generated by somatic mutation. These findings indicate that dual receptor B lymphocytes can be found among mature antigen-selected B cells and suggest that somatic mutation can contribute to increase the degree of isotypic exclusion by inactivating a passenger, nonselected L chain.
New Data Analysis Tools for X-ray Photoelectron Spectroscopy (XPS) and Spectroscopic Ellipsometry (SE): Uniqueness Plots and Width Functions in XPS, and Distance, Principal Component, and Cluster Analyses in SE (2016)

Journal Article New Data Analysis Tools for X-ray Photoelectron Spectroscopy (XPS) and Spectroscopic Ellipsometry (SE): Uniqueness Plots and Width Functions in XPS, and Distance, Principal Component, and Cluster Analyses in SE Get access Matthew R Linford, Matthew R Linford Departments of Chemistry and Biochemistry and Search for other works by this author on: Oxford Academic Google Scholar Bhupinder Singh, Bhupinder Singh Departments of Chemistry and Biochemistry and Search for other works by this author on: Oxford Academic Google Scholar Daniel Velázquez, Daniel Velázquez Department of Physics, Illinois Institute of Technology, Chicago, IL, USA Search for other works by this author on: Oxford Academic Google Scholar Jeff Terry, Jeff Terry Department of Physics, Illinois Institute of Technology, Chicago, IL, USA Search for other works by this author on: Oxford Academic Google Scholar Jacob D Bagley, Jacob D Bagley Departments of Chemistry and Biochemistry and Search for other works by this author on: Oxford Academic Google Scholar Dennis H Tolley, Dennis H Tolley CINVESTAV-Unidad Queretaro, Queretaro, Mexico Search for other works by this author on: Oxford Academic Google Scholar Anubhav Diwan, Anubhav Diwan Departments of Chemistry and Biochemistry and Search for other works by this author on: Oxford Academic Google Scholar Varun Jain, Varun Jain Departments of Chemistry and Biochemistry and Search for other works by this author on: Oxford Academic Google Scholar Alberto Herrera-Gomez Alberto Herrera-Gomez CINVESTAV-Unidad Queretaro, Queretaro, Mexico Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 344–345, https://doi.org/10.1017/S1431927616002579 Published: 25 July 2016
Enantio-differentiation of O-heterocycles using a binol-derived disulfonimide as a chiral solvating agent (2014)

The disulfonimide (R)-1 enables enantio-differentiation of a large scope of chiral O-heterocycles, thanks to the formation of diastereomeric adducts. The underlying H-bond has been investigated by NMR. (R)-1 has been used as a chiral solvating agent (CSA) to determine the stereochemical purity of D/L lactide by (1)H NMR.
Bayesian Neural Network Realization by Exploiting Inherent Stochastic Characteristics of Analog RRAM (2019)

For the first time, this paper develops a novel stochastic computing method by utilizing the inherent random noises of analog RRAM. With the designed analog switching characteristics, the RRAM device can realize the function of sampling from a tunable probabilistic distribution. A Bayesian neural network (BayNN), whose weights are represented by probability distributions, is experimentally demonstrated on the fabricated 160K RRAM array. The measured result achieves 97% accuracy for image classification on MNIST dataset. Moreover, the RRAM based BayNN shows anti-attack capability with inherent device stochastic behavior to detect "adversarial" images, which are generated by adding noises to the original MNIST images and can fool the conventional deep neural networks. This is the first demonstration work for the widely-used BayNN algorithms with emerging devices.
Design of a shim coil array matched to the human brain anatomy (2019)

The results demonstrate the validity of the proposed method to design a shim coil array matched to the human brain anatomy, which naturally satisfies the laws of electrodynamics. The design method may also be applied to develop new shim coil arrays matched to other human organs.
Nanoscale 3D Refractive Indices Mapping on Native Cheek Cells by Axial Scanning Transmission Electron Tomography (2015)

Scanning transmission electron microscopy (STEM) has been engaged in the study of ultrastructure of biological samples both qualitatively and quantitatively since the 1970s In particular, high angle annular dark field (HAADF) detector collects electrons been scattered above a pre-defined large angle. The contrast given by those high-angle scattered electrons, which are described by Rutherford's scattering model, is proportional to mass. Thus nano-scale, quantitative 2D projection mass mapping of biological complex can be done by calibrating HAADF images with molecules with similar chemical composition and known mass or density However, 2D projection data is notoriously hard to interpret, if not impossible. To tackle the problem, 3D tomography information is needed. It has been proven that 3D tomography of a whole human erythrocyte infected with the malaria parasite Plasmodium falciparum can be reconstructed by tilting each of the thick serial cryo-sections (around 1m)with 8-10 nmresolution using STEM axial detector
SIMO and MIMO FDE transmission in optical fiber with PMD (2010)

This paper considers a PMD compensation method using FDE and analytically shows that MMSE based SIMO and MIMO FDE weights in the PMD channel are identical because of the unitarity of the Jones matrix.