gebhart/patrepeval huggingface dataset:
C−H Bond Activation of Hydrocarbon Segments in Complex Organic Molecules:  Total Synthesis of the Antimitotic Rhazinilam (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTC−H Bond Activation of Hydrocarbon Segments in Complex Organic Molecules: Total Synthesis of the Antimitotic RhazinilamJames A. Johnson and Dalibor SamesView Author Information Department of Chemistry, Columbia University New York, New York 10027 Cite this: J. Am. Chem. Soc. 2000, 122, 26, 6321–6322Publication Date (Web):June 16, 2000Publication History Received31 January 2000Published online16 June 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/ja0003223https://doi.org/10.1021/ja0003223rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3430Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Ethyl groups,Group 10 complexes,Hydrocarbons,Metals,Pyrroles Get e-Alerts
A Tissue Engineering Model for Tractional Organization of Cells and Matrices (2001)

Abstract Tissues are characterized by highly distinctive microarchitecture and overall form that are critical to tissue specific function. with increasing interest in tissue engineering to create surrogates for human tissues and organs, innovative techniques have been developed to generate scaffolds that display form, and microarchitecture mimicking physiological structures. While this artifice may generate pre-programmed shapes, it fails to take advantage of the inherent ability of cells to organize themselves and their surroundings. The generation of mechanical forces by the cellular cytoskeleton plays a critical role in the organization of matrix and of cellular colonies. The anchorage of the cytoskeleton to a substrate is essential for cellular tractional processes. in tissues, cells are anchored in a stationary, 3-D network of collagen in a highly characteristic spatial arrangement. This spatial order arises from vectorial deposition of matrix and its subsequent tractional organization by cells. The junction of the cell binding domain of collagen with specific integrin receptors, and the cells’ cytoskeleton comprises the apparatus for the interconversion of mechanical and biochemical energy.
Use of a building database in prediction of three-dimensional diffraction (2003)

The use of a building database and a three-dimensional formulation of the Fresnel-Kirchoff diffraction theory to compute the shadowing by buildings in the general situation where diffraction can occur by building edges of both horizontal and vertical orientation is described. The storage format of buildings in a geographic information system database is described. An algorithm for identifying the nearest diffracting building and deriving the necessary information for the evaluation of the diffraction integral is presented. Example results are presented to show the utility of this approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Novel biomarkers in critical care: utility or futility? (2007)

One of the holy grails of modern medicine, across a range of clinical sub-specialties, is establishing highly sensitive and specific biomarkers for various diseases. Significant success has been achieved in some of these clinical areas, most notably identifying high-sensitivity C-reactive peptide, troponin I/T and brain natriuretic peptide as significant prognosticators for both the acute outcome and the development of cardiovascular pathology. However, it is highly debatable whether this translates to complex, multi-system pathophysiological insults. Is critical care immune from the application of these novel biomarkers, given the numerous confounding factors interfering with their interpretation?
Positive Versus Negative Modulation of Different Endogenous Chemokines for CC-chemokine Receptor 1 by Small Molecule Agonists through Allosteric Versus Orthosteric Binding (2008)

7 transmembrane-spanning (7TM) chemokine receptors having multiple endogenous ligands offer special opportunities to understand the molecular basis for allosteric mechanisms. Thus, CC-chemokine receptor 1 (CCR1) binds CC-chemokine 3 and 5 (CCL3 and CCL5) with K(d) values of 7.3 and 0.16 nm, respectively, as determined in homologous competition binding assays. However, CCL5 appears to have a >10,000-fold lower affinity in competition against (125)I-CCL3. Mutational mapping revealed that CCL3 and CCL5 both are strongly affected by systematic truncations of the N-terminal extension, whereas only CCL5 and not CCL3 activation is affected by substitutions in the main ligand binding pocket including the conserved GluVII:06 anchor point. A series of metal ion chelator complexes were found to act as full agonists on CCR1 and to be critically affected by the same substitutions in the main ligand binding pocket as CCL5 but not by mutations in the extracellular domain. In agreement with the overlapping binding sites, the small non-peptide agonists displaced radiolabeled CCL5 with high affinity. Interestingly, the same compounds acted as allosteric enhancers of the binding of CCL3, with which they did not overlap in binding site, leading to an increased B(max) and affinity of this chemokine mainly due to an increased association rate. It is concluded that a small molecule agonist through binding deep in the main ligand binding pocket can act as an allosteric enhancer for one endogenous chemokine and at the same time as a competitive blocker of the binding of another endogenous chemokine.
Spherical nanoindentation stress-strain analysis, Version 1 (2016)

Nanoindentation is a tool that allows the mechanical response of a variety of materials at the nano to micron length scale to be measured. Recent advances in spherical nanoindentation techniques have allowed for a more reliable and meaningful characterization of the mechanical response from nanoindentation experiments in the form on an indentation stress-strain curve. This code base, Spin, is written in MATLAB (The Mathworks, Inc.) and based on the analysis protocols developed by S.R. Kalidindi and S. Pathak [1, 2]. The inputs include the displacement, load, harmonic contact stiffness, harmonic displacement, and harmonic load from spherical nanoindentation tests in the form of an Excel (Microsoft) spreadsheet. The outputs include indentation stress-strain curves and indentation properties as well their variance due to the uncertainty of the zero-point correction in the form of MATLAB data (.mat) and figures (.png). [1] S. Pathak, S.R. Kalidindi. Spherical nanoindentation stress–strain curves, Mater. Sci. Eng R-Rep 91 (2015). [2] S.R. Kalidindi, S. Pathak. Determination of the effective zero-point and the extraction of spherical nanoindentation stress-strain curves, Acta Materialia 56 (2008) 3523-3532.
Interaction of the Conserved Region 4.2 of ςE with the RseA Anti-sigma Factor (2002)

Esigma(E) RNA polymerase transcribes a regulon of folding factors for the bacterial envelope and is induced by physical and chemical stresses. The RseA anti-sigma factor inhibits the activity of Esigma(E) RNA polymerase. It is shown here that the N-terminal portion of sigma(E), residues 1-153, binds core RNA polymerase. RseA interacts with residues 154-191 of sigma(E), a site that is homologous to region 4, the sigma factor binding site for promoter DNA. Mutations that reduce transcription of Esigma(E) RNA polymerase map to sigma(E) residues 178, 181, and 183. Variant sigma(E) proteins with amino acid substitutions at residues 178, 181, or 183 do not associate with RseA. A regulatory mechanism is proposed whereby RseA binds to a C-terminal peptide of sigma(E) and inhibits the transcription of Esigma(E) RNA polymerase by blocking promoter recognition.
Exploration of Artificial Frustrated Magnets (2015)

This program encompasses experimental and theoretical studies of arrays of nanometer-scale magnets known as “artificial frustrated magnets”. These magnets are small and closely spaced, so that their behavior as a collective group is complex and reveals insights into how such collections of interacting objects behave as a group. In particular, the placement of the magnets is such that the interactions between them are “frustrated”, in that they compete with each other. These systems are analogs to a class of magnetic materials in which the lattice geometry frustrates interactions between individual atomic moments, and in which a wide range of novel physical phenomena have been recently observed. The advantage to studying the arrays is that they are both designable and resolvable: i.e., the experiments can control all aspects of the array geometry, and can also observe how individual elements of the arrays behave. This research program demonstrated a number of phenomena including the role of multiple collective interactions, the feasibility of using systems with their magnetism aligned perpendicular to the plane of the array, the importance of disorder in the arrays, and the possibility of using high temperatures to adjust the magnet orientations. All of these phenomena, and others explored in this program, add to the body of knowledge around collective magnetic behavior and magnetism in general. Aside from building scientific knowledge in an important technological area, with relevance to computing and memory, the program also gave critical support to the education of students working on the experiments.
Volumetric muscle loss injury repair using in situ fibrin gel cast seeded with muscle-derived stem cells (MDSCs) (2018)

Volumetric muscle defect, caused by trauma or combat injuries, is a major health concern leading to severe morbidity. It is characterized by partial or full thickness loss of muscle and its bio-scaffold, resulting in extensive fibrosis and scar formation. Therefore, the ideal therapeutic option is to use stem cells combined with bio-scaffolds to restore muscle. For this purpose, muscle-derived stem cells (MDSCs) are a great candidate due to their unique multi-lineage differentiation potential. In this study, we evaluated the regeneration potential of MDSCs for muscle loss repair using a novel in situ fibrin gel casting. Muscle defect was created by a partial thickness wedge resection in the tibialis anterior (TA) muscles of NSG mice which created an average of 25% mass loss. If untreated, this defect leads to severe muscle fibrosis. Next, MDSCs were delivered using a novel in situ fibrin gel casting method. Our results demonstrated MDSCs are able to engraft and form new myofibers in the defect when casted along with fibrin gel. LacZ labeled MDSCs were able to differentiate efficiently into new myofibers and significantly increase muscle mass. This was also accompanied by significant reduction of fibrotic tissue in the engrafted muscles. Furthermore, transplanted cells also contributed to new vessel formation and satellite cell seeding. These results confirmed the therapeutic potential of MDSCs and feasibility of direct in situ casting of fibrin/MDSC mixture to repair muscle mass defects.
Precision repositioning of the balancing ball in an auto-balancer system via a fuzzy speed regulator equipped with a sliding-mode observer (2005)

An intelligent fuzzy rotor speed-regulator is developed to reposition the balancing ball inside an automatic balancer system (ABS) to its desired location. This repositioning is designed and activated to remedy the commonly-seen mis-positionings of the rolling ball inside ABS, which is caused by an inevitable rolling friction moment of the rolling ball in contact with its race, leading to large, undesired radial vibrations. The repositioning is accomplished by essentially generating required circumferential inertial force on the ball to suppress the rolling friction. For preliminary feasibility, the case of a single ball is considered. The first step is to establish the dynamic model of the system, which is followed by the analysis to ensure stability of the desired ball equilibrium position. The second step is to forge a sliding-mode observer for estimating online position and velocity of the ball, which are offered to the fuzzy speed-regulator as inputs. The fuzzy speed regulator is then synthesized by three parts: fuzzification of inputs/output, the rule table, and a reference engine accompanied by defuzzification. Finally, an incremental speed-adjustment scheme is designed in order for the spindle to reach target operating speed, while retaining the ball at the desired position. Simulations and experiments are conducted to demonstrate the effectiveness of the proposed fuzzy ball-repositioning scheme.
(n,m)-Assigned Absorption and Emission Spectra of Single-Walled Carbon Nanotubes (2003)

Spectroscopic studies of SWNT samples enriched in individual, surfactant‐suspended nanotubes have revealed distinct absorption and emission transitions for more than 30 different semiconducting (n,m) species. Through the combined use of pattern analysis, qualitative model calculations, and resonance Raman measurements of radial breathing mode frequencies, (n,m) indices were assigned to the first‐ and second‐van Hove optical transitions of 33 different species. The results show large systematic deviations from a simple dependence of transition wavelength on tube diameter, suggesting the presence of substantial excitonic effects in addition to trigonal warping patterns. Tight‐binding models are not successful in simulating the results. An experimental, model‐free plot of transition energy vs. nanotube diameter is now available. It is advisable to use this in preference to theoretically constructed Kataura plots, which contain substantial errors. Optical spectroscopy will also prove a valuable tool for selective, sensitive, rapid, and nondestructive analysis of bulk nanotube samples.
Privacy-preserving record linkage using local sensitive hash and private set intersection (2022)

The amount of data stored in data repositories increases every year. This makes it challenging to link records between different datasets across companies and even internally, while adhering to privacy regulations. Address or name changes, and even different spelling used for entity data, can prevent companies from using private deduplication or record-linking solutions such as private set intersection (PSI). To this end, we propose a new and efficient privacy-preserving record linkage (PPRL) protocol that combines PSI and local sensitive hash (LSH) functions, and runs in linear time. We explain the privacy guarantees that our protocol provides and demonstrate its practicality by executing the protocol over two datasets with $2^{20}$ records each, in $11-45$ minutes, depending on network settings.
Transcriptional and metabolomic analysis of Ascophyllum nodosum mediated freezing tolerance in Arabidopsis thaliana (2012)

Taken together, the results of the experiments presented in this paper provide evidence to support LPC mediated freezing tolerance enhancement through a combination of the priming of plants for the increased accumulation of osmoprotectants and alteration of cellular fatty acid composition.
Transparent Antiradiative Ferroelectric Heterostructure Based on Flexible Oxide Heteroepitaxy (2018)

In the era of Internet of Things, the demand for flexible and transparent electronic devices has shifted to the forefront of materials science research. However, the radiation damage to key performance of transparent devices under radiative environment remains as a critical issue. Here, we present a promising technology for nonvolatile transparent electronic devices based on flexible oxide heteroepitaxy. A direct fabrication of epitaxial lead lanthanum zirconate titanate on transparent flexible mica substrate with indium tin oxide electrodes is presented. The transparent flexible ferroelectric heterostructures not only retain their superior performance, thermal stability, reliability, and mechanical durability, but also exhibit remarkably robust properties against to a strong radiation exposure. Our study demonstrates an extraordinary concept to realize transparent flexible nonvolatile electronic devices for the design and development of next-generation smart devices with potential application in electronics, automotive, aerospace, and nuclear systems.
Incorporating assessment of fibrinogen gene polymorphisms and bleeding risk in patients treated with direct oral anticoagulants (2023)

Direct oral anticoagulants (DOACs) have become entrenched as the dominant anticoagulant over the last decade for patients with venous thrombosis and atrial fibrillation.1 Compared to warfarin, bleeding risk is similar or lower for patients on DOACs but clinically relevant bleeding is still a risk, especially for patients with impaired organ function.2
A metamerism-based method to prevent camcorder movie piracy in digital theaters (2010)

This document proposes a new, multi-primary projection system for prevention of illegal recordings in movie theaters. As of today, most camcorder-jamming methods tend to rely on either Infra-Red or spatial/temporal light modulations, both being easy to defeat using an appropriate filter system. Like Infra-Red, a metamerism-based system will modulate light magnitude depending on wavelength, but this time within the range of visible light, making jamming patterns harder to filter out. The mathematical model we use to solve our problem can actually serve as a generic model for all spectrum-based methods, including IR.
Supplementary Video S2A from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma (2023)

&lt;p&gt;40 min full dynamic Total-body PET imaging of Patient 1&lt;/p&gt;
Prognostic factors and treatment outcome in primary progressive Hodgkin lymphoma: a report from the German Hodgkin Lymphoma Study Group (2000)

To determine prognostic factors and treatment outcome, patients with primary progressive Hodgkin lymphoma (HD) registered in the database of the German Hodgkin Lymphoma Study Group (GHSG) were analyzed retrospectively. Detailed records from randomized prospective multicenter trials performed between 1988 and 1998 of 3807 patients recruited in these trials were reviewed. The median age of the 206 patients available was 34 years (range, 16-71). Fifty-seven patients (28%) in intermediate stage and 149 patients (72%) in advanced stage developed progressive disease (PD). One hundred and fifty-three patients (74%) were treated with salvage chemotherapy, 47 patients (23%) with salvage radiotherapy, and 6 patients (3%) did not receive any therapy due to rapid PD. Seventy patients (34%) were treated with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. The 5-year freedom from second failure (FF2F) and overall survival (OS) for all patients were 17% and 26%, respectively. The 5-year FF2F and OS for patients treated with HDCT were 31% and 43%, respectively. In multivariate analysis low Karnofsky performance score at the time of progression (P &lt; .0001), age above 50 years (P = .019), and failure to attain a temporary remission on first-line treatment (P = .0003) were significant adverse prognostic factors for OS. Patients with none of these risk factors had a 5-year OS of 55% compared with 0% for patients with all 3 of these unfavorable prognostic factors. Although HDCT is a reasonable option for selected patients with primary progressive HD, the majority did not receive HDCT. Interestingly, salvage radiotherapy gave promising results in patients with localized PD.
Magnetization of ternary alloys based on Fe0.65Ni0.35 invar with 3d transition metal additions: An ab initio study (2015)

Smart susceptors are being developed for use as tooling surfaces in molding machines that use apply electro-magnetic induction heating to mold and form plastics or metal powders into structural parts, e.g., on aerospace and automotive manufacturing lines. The optimal magnetic materials for the induction heating process should have large magnetization, high magnetic permeability, but also small thermal expansion coefficient. The Fe0.65Ni0.35 invar alloy with its negligible thermal expansion coefficient is thus a natural choice for this application. Here, we use density functional theory as implemented through the Korringa-Kohn-Rostoker method within the coherent-potential approximation, to design new alloys with the large magnetization desired for smart susceptor applications. We consider the Fe0.65–xNi0.35–yMx+y alloys derived from Fe0.65Ni0.35 invar adding a third element M = Sc, Ti, V, Cr, Mn, or Co with concentration (x + y) reaching up to 5 at. %. We find that the total magnetization depends linearly on the concentration of M. Specifically, the early 3d transition metals from Sc to Cr decrease the magnetization with respect to that of the invar alloy whereas Mn and Co increase it.
Sustainability assurance modeling for SRAM-based FPGA evolutionary self-repair (2014)

A quantitative stochastic design technique is developed for evolvable hardware systems with self-repairing, replaceable, or amorphous spare components. The model develops a metric of sustainability which is defined in terms of residual functionality achieved from pools of amorphous spares of dynamically configurable logic elements, after repeated failure and recovery cycles. At design-time the quantity of additional resources needed to meet mission availability and lifetime requirements given the fault-susceptibility and recovery capabilities are assured within specified constraints. By applying this model to MCNC benchmark circuits mapped onto Xilinx Virtex-4 Field Programmable Gate Array (FPGA) with reconfigurable logic resources, we depict the effect of fault rates for aging-induced degradation under Time Dependent Dielectric Breakdown (TDDB) and interconnect failure under Electromigration (EM). The model considers a population-based genetic algorithm to refurbish hardware resources which realize repair policy parameters and decaying reparability as a complete case-study using published component failure rates.