gebhart/patrepeval huggingface dataset:
AN IMPERFECT MICROBEAM UNDER AN AXIAL LOAD AND ELECTRIC EXCITATION: NONLINEAR PHENOMENA AND DYNAMICAL INTEGRITY (2013)

This work deals with the nonlinear dynamics of a microelectromechanical system constituted by an imperfect microbeam under an axial load and an electric excitation. The device is characterized by a bistable static configuration. We analyze the single-mode dynamics and describe the overall scenario of the response, up to the inevitable escape, when both the frequency and the electrodynamic voltage are considered as driving parameters. We observe the presence of several competing attractors leading to a considerable versatility of behavior, which may have many feasible applications. Extensive numerical simulations are performed. The frequency-dynamic voltage behavior chart is obtained, which detects the theoretical boundaries of appearance and disappearance of the main attractors. Taking into account the erosion of the double well, we investigate the final response when each attractor vanishes. All these results represent the limit when disturbances are absent, which never occurs in practice. To extend them to the practical case where disturbances exist, we develop a dynamical integrity analysis. This is performed via curves of constant percentage of local integrity measure, which give quantitative information about the changes in the structural safety. For each attractor, we examine both the practical disappearance, by analyzing the robustness of its basin along the range of existence, and the practical final response, by detecting where safe jump to another attractor may be ensured and where instead dynamic pull-in may arise. These curves may be used to establish safety factors in order to operate the device according to the desired outcome, depending on the expected disturbances.
<title>Microwave photonics for broadband wireless access</title> (1999)

The concept of a sending-mode patch antenna array with an optical feeder and beamforming network is discussed. We describe the design of the patch antennas, and we present measured results for the impedance, the far- and the near- fields. Data for an integrated photoreceiver are given. Finally, we review some essential aspects of optical beamforming networks.
Coupling of Nitrogen-Vacancy Centers to Photonic Crystal Cavities in Monocrystalline Diamond (2012)

The zero-phonon transition rate of a nitrogen-vacancy center is enhanced by a factor of ∼70 by coupling to a photonic crystal resonator fabricated in monocrystalline diamond using standard semiconductor fabrication techniques. Photon correlation measurements on the spectrally filtered zero-phonon line show antibunching, a signature that the collected photoluminescence is emitted primarily by a single nitrogen-vacancy center. The linewidth of the coupled nitrogen-vacancy center and the spectral diffusion are characterized using high-resolution photoluminescence and photoluminescence excitation spectroscopy.
Correlations between Molecular Structure and Single-Junction Conductance: A Case Study with Oligo(phenylene-ethynylene)-Type Wires (2012)

The charge transport characteristics of 11 tailor-made dithiol-terminated oligo(phenylene-ethynylene) (OPE)-type molecules attached to two gold electrodes were studied at a solid/liquid interface in a combined approach using an STM break junction (STM-BJ) and a mechanically controlled break junction (MCBJ) setup. We designed and characterized 11 structurally distinct dithiol-terminated OPE-type molecules with varied length and HOMO/LUMO energy. Increase of the molecular length and/or of the HOMO-LUMO gap leads to a decrease of the single-junction conductance of the linearly conjugate acenes. The experimental data and simulations suggest a nonresonant tunneling mechanism involving hole transport through the molecular HOMO, with a decay constant β = 3.4 ± 0.1 nm(-1) and a contact resistance R(c) = 40 kΩ per Au-S bond. The introduction of a cross-conjugated anthraquinone or a dihydroanthracene central unit results in lower conductance values, which are attributed to a destructive quantum interference phenomenon for the former and a broken π-conjugation for the latter. The statistical analysis of conductance-distance and current-voltage traces revealed details of evolution and breaking of molecular junctions. In particular, we explored the effect of stretching rate and junction stability. We compare our experimental results with DFT calculations using the ab initio code SMEAGOL and discuss how the structure of the molecular wires affects the conductance values.
Cloning of a pig glucose transporter 4 cDNA fragment: use in developing a sensitive ribonuclease protection assay for quantifying low-abundance glucose transporter 4 mRNA in porcine adipose tissue (1994)

A 246-bp fragment of porcine glucose transporter 4 (GLUT4) cDNA was cloned by polymerase chain reaction (PCR) from porcine adipose tissue RNA. Nucleotide sequences 1-138 and 139-246 of the GLUT4 cDNA share 78% sequence identity with exon 4a and 91% sequence identity with exon 4b of the human GLUT4 gene, respectively. The GLUT4 cDNA fragment was subcloned into pGEM-4Z vector to synthesize a highly specific riboprobe that hybridized only to human GLUT4 cDNA but not to human glucose transporter 1 (GLUT1) cDNA. Northern blot analysis of total RNA revealed the presence of a single transcript of 2.8 kb in porcine adipose tissue. Cloning a fragment of the GLUT4 cDNA enabled us to develop a ribonuclease protection assay for detecting porcine GLUT4 mRNA. The ribonuclease (RNase) protection assay is highly reproducible and retains a sensitivity level to as little as 2 pg of GLUT4 mRNA. The standard curve was linear between 2 and 128 pg of sense-strand GLUT4 RNA (r = .994). The ability to detect small quantities of GLUT4 mRNA is important when the abundance of GLUT4 mRNA is low and the quantity of tissue is limiting (e.g., when RNA is extracted from cultured adipose tissue). When porcine adipose tissue explants were cultured in the presence of insulin (10 ng/mL), GLUT4 mRNA abundance was increased. Development of a sensitive assay to quantify GLUT4 mRNA in porcine adipose tissue will enable us to conduct studies to increase our understanding of the molecular mechanisms by which porcine somatotropin (pST) regulates GLUT4 gene expression.
Supplementary Table 1 from Cancer Cell–Associated MT1-MMP Promotes Blood Vessel Invasion and Distant Metastasis in Triple-Negative Mammary Tumors (2023)

Supplementary Table 1 from Cancer Cell–Associated MT1-MMP Promotes Blood Vessel Invasion and Distant Metastasis in Triple-Negative Mammary Tumors
Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast (2022)

Abstract Aneuploidy compromises genomic stability, often leading to embryo inviability, and is frequently associated with tumorigenesis and aging. Different aneuploid chromosome stoichiometries lead to distinct transcriptomic and phenotypic changes, making it helpful to study aneuploidy in tightly controlled genetic backgrounds. By deploying the engineered SCRaMbLE system to the newly synthesized Sc2.0 megabase chromosome VII ( synVII ), we constructed a synthetic disomic yeast and screened hundreds of SCRaMbLEd derivatives with diverse chromosomal rearrangements. Phenotypic characterization and multi-omics analysis revealed that fitness defects associated with aneuploidy could be restored by i) removing most of the chromosome content, or ii) modifying specific regions in the duplicated chromosome. These findings indicate that both chromosome copy number and chromosomal regions contribute to the aneuploidy-related phenotypes, and the synthetic yeast resource opens new paradigms in studying aneuploidy. In brief Use of SCRaMbLE and newly synthesized Mb-scale Sc2.0 chromosome VII enables insights into genotype/phenotype relationships associated with aneuploidy Highlights De novo design and synthesis of a Mb-scale synthetic yeast chromosome VII, carrying 11.8% sequence modifications and representing nearly 10% of the yeast genome. A disomic yeast (n + synVII ) is constructed for dissecting the aneuploidy phenotype SCRaMbLE enables systematic exploration of regions causing aneuploidy phenotypes Chromosomal copy number and content both contribute to aneuploidy phenotypes A 20 Kb deletion on the right arm of synVII leads to fitness improvement linked to up-regulation of protein synthesis
Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes (2013)

Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.
The effect of topical intraperitoneal bupivacaine on post-operative pain following laparoscopic cholecystectomy (1995)

SummaryLaparoscopic cholecystectomy is associated with less patient discomfort, shorter hospital stays and more rapid return to work than open cholecystectomy. Nevertheless, it is not a pain free procedure. Peritoneal irritation at the time of surgery can cause significant pain. Topical instillation of local anaesthetics reduces post-operative pain following diagnostic laparoscopy and laparoscopic tubal ligations. A similar benefit has not been demonstrated in upper abdominal laparoscopic procedures. This study was designed to assess the effect on post-operative pain of 30 cc of 0.5% bupivacaine with 1:200000 epinephrine administered at the completion of laparoscopic cholecystectomy. Laparoscopic cholecystectomy was performed on 46 patients, 23 of whom received bupivacaine and 23 received saline. Post-operative pain was assessed by reviewing nursing records and by analysis of analgesic requirements of each patient. In patients receiving bupivacaine, analgesic requirement was significantly lower at 4–8 h and 24 h post-operatively. The fraction of patients receiving bupivacaine who subjectively reported pain to nurses (10/23) was significantly less than in the control group (18/23). Patients receiving bupivacaine also had a significantly shorter hospital stay than patients in the control group (1.3 days versus 1.9 days). We conclude that topical administration of bupivacaine at the completion of laparoscopic cholecystectomy diminishes post-operative pain and decreases hospital stay. Long-acting local anaesthetics provide significantly increased post-operative pain control when administered at the completion of laparoscopic procedures.Key Words: laparoscopycholecystectomypost-operative painanalgesiabupivacaine
[Total Hip Arthroplasty after previous proximal femoral osteotomy]. (2007)

It is technically difficult to perform total hip arthroplasty (THA) after osteotomy because the proximal femur may be deformed after primary osteotomy. For the deformity of femur, combination with femoral osteotomy should be performed. The results obtained on performing THA after osteotomy have been described by some investigators. The main reasons of failure were malposion of stem, intraoperative fracture, dislocation, nonunion, and infection. This paper treats regards to avert these complications.
Encoding of Attributes of LSP intermediate hops using RSVP-TE (2009)

RFC5420 specifies a general framework to support signaling and
reporting of generic attributes relevant for a signaled LSP. This
document extends the concept and defines a new Explicit Route
subobject for RSVP-TE to allow the specification and reporting of
attributes relevant to a particular hop of the signaled LSP.
Bile Acids as Hormones: The FXR-FGF15/19 Pathway (2015)

While it has long been recognized that bile acids are essential for solubilizing lipophilic nutrients in the small intestine, the discovery in 1999 that bile acids serve as ligands for the nuclear receptor farnesoid X receptor (FXR) opened the floodgates in terms of characterizing their actions as selective signaling molecules. Bile acids act on FXR in ileal enterocytes to induce the expression of fibroblast growth factor (FGF)15/19, an atypical FGF that functions as a hormone. FGF15/19 subsequently acts on a cell surface receptor complex in hepatocytes to repress bile acid synthesis and gluconeogenesis, and to stimulate glycogen and protein synthesis. FGF15/19 also stimulates gallbladder filling. Thus, the bile acid-FXR-FGF15/19 signaling pathway regulates diverse aspects of the postprandial enterohepatic response. Pharmacologically, this endocrine pathway provides exciting new opportunities for treating metabolic disease and bile acid-related disorders such as primary biliary cirrhosis and bile acid diarrhea. Both FXR agonists and FGF19 analogs are currently in clinical trials.
Investigation of Slider Vibrations Due to Contact With a Smooth Disk Surface (2000)

The dynamic behavior of pico sliders is investigated during slider-disk contacts as a function of velocity, pitch angle, crown height, and lubricant thickness using laser Doppler vibrometry and acoustic emission sensors. Analog and digital filtering methods are applied to distinguish air bearing and slider body resonances from frequencies related to disk runout, load beam design, and gimbal structure. Sliders with high pitch angle and small crown were found to exhibit smaller vibration amplitudes after slider-disk contacts than sliders with low pitch angle or large crown. The lubricant thickness of the disk was found to affect both the glide avalanche height of the disk and the dynamic behavior of the slider. The results show that roll and pitch frequencies of the air bearing increase with decreasing disk velocity.
Multiple Testing Methods For ChIP-Chip High Density Oligonucleotide Array Data (2004)

Cawley et al. (2004) have recently mapped the locations of binding sites for three transcription factors along human chromosomes 21 and 22 using ChIP-Chip experiments. ChIP-Chip experiments are a new approach to the genome-wide identification of transcription factor binding sites and consist of chromatin (Ch) immunoprecipitation (IP) of transcription factor-bound genomic DNA followed by high density oligonucleotide hybridization (Chip) of the IP-enriched DNA. We investigate the ChIP-Chip data structure and propose methods for inferring the location of transcription factor binding sites from these data. The proposed methods involve testing for each probe whether it is part of a bound sequence or not using a scan statistic that takes into account the spatial structure of the data. Different multiple testing procedures are considered for controlling the family-wise error rate and false discovery rate. A nested-Bonferroni adjustment, that is more powerful than the traditional Bonferroni adjustment when the test statistics are dependent, is discussed. Simulation studies show that taking into account the spatial structure of the data substantially improves the sensitivity of the multiple testing procedures. Application of the proposed methods to ChIP-Chip data for transcription factor p53 identified many potential target binding regions along human chromosomes 21 and 22. Among these identified regions, 18% fall within a 3kb vicinity of the 5'UTR of a known gene or CpG island, 31% fall between the codon start site and the codon end site of a known gene but not inside an exon. More than half of these potential target sequences contain the p53 consensus binding site or very close matches to it. Moreover, these target segments include the 13 experimentally verified p53 binding regions of Cawley et al. (2004), as well as 49 additional regions that show higher hybridization signal than these 13 experimentally verified regions.
Metabolic Interaction between Ammonia and Baicalein (2020)

Ammonia is treated as a primary waste product of cellular metabolism <i>in vivo</i> and can contribute to the alteration of neurotransmission, oxidative stress, and cerebral edema and astrocyte swelling when its concentration in the brain is high. The objective of this study was to determine whether bioactive polyphenol baicalein had the capacity to trap ammonia <i>in vitro</i> and <i>in vivo</i>. Under <i>in vitro</i> conditions, baicalein rapidly reacted with ammonia to generate two monoaminated products and one diaminated product under different reaction times. These three major aminated products were purified from the reaction mixture, and their structures were characterized as 5-NH<sub>2</sub>-baicalein, 6-NH<sub>2</sub>-baicalein, and 5,6-di-NH<sub>2</sub>-baicalein based on the analysis of their HR-MS and 1D- and 2D-NMR data. In mice, both 5-NH<sub>2</sub>-baicalein and 6-NH<sub>2</sub>-baicalein were detected in 24 h fecal and urine samples collected from mice treated with baicalein (200 mg/kg) through oral gavage, and 6-NH<sub>2</sub>-baicalein was also detected in mouse plasma and brain samples collected at 0.5 h after baicalein treatment. Significant amounts of 6-NH<sub>2</sub>-baicalein were detected in all mouse samples including feces, urine, plasma, and brain. The levels of 6-NH<sub>2</sub>-baicalein in feces and urine were significantly higher than those of 5-NH<sub>2</sub>-baicalein. Furthermore, the average level of 6-NH<sub>2</sub>-baicalein was very close to that of baicalein (3.62 vs 3.77 ng/g) in mouse brain, suggesting it is possible that baicalein has the capacity to be absorbed rapidly into the circulation system and then cross the blood-brain barrier into the brain to detoxify ammonia in the blood and brain. In conclusion, this study confirmed that baicalein, a flavonoid with a <i>vic</i>-trihydroxyl structure on the A-ring, has the potential to detoxify ammonia and treat ammonia-associated chronic diseases.
Diabetic Retinopathy Is Related to Both Endothelium-Dependent and -Independent Responses of Skin Microvascular Flow (2011)

The presence of DR was associated with a reduction in skin microcirculation responses to iontophoresis of both SNP and ACh, suggesting that vascular processes associated with both endothelial dysfunction and endothelial function-independent mechanisms may be pathogenically related to DR.
Molecular genetics of small bowel cancer. (1997)

Although the molecular genetic changes that take place during carcinogenesis in the large bowel have been well elucidated, very little work has been done on the carcinogenesis process in the small bowel where this phenomenon is much rarer. The few studies that have been done to suggest that certain oncogenes, i.e., erbB2, K-ras, cyclin D1, and p53, are all altered in ways and in frequency similar to these phenomena in large bowel cancer. Some tumor markers have been noted to occur in malignant carcinoid tumours as well. Given the overall similarities in the epidemiology and the role of the adenoma-carcinoma sequence for both small bowel adenocarcinoma and colorectal adenocarcinoma, it is highly likely that the same molecular genetic changes play a major role. Further work is needed to confirm this. If true, a potentially important are of future research would be to determine why these molecular genetic changes occur so much less frequently in the small bowel as compared to the large bowel.
Receptor-mediated endocytosis of keratinocyte growth factor (1998)

Keratinocyte growth factor (KGF) is a fibroblast growth factor which acts specifically on epithelial cells, regulating their proliferation and differentiation. KGF elicits its activity through binding to and activation of KGF receptor, a splicing transcript variant of fibroblast growth factor receptor 2 (FGFR2). Here we analyzed the pathway of internalization of KGF and its receptor using several approaches, including the utilization in immunofluorescence and in immunoelectron microscopy of a functional KGF-HFc chimeric protein as a specific tool to follow the endocytosis of the growth factor and of its receptor. Western blot analysis with anti-FGFR2 and anti-phosphotyrosine antibodies, as well as parallel double immunofluorescence and confocal analysis of NIH3T3 KGFR transfectants treated with KGF at 4 degrees C, followed by incubations at 37 degrees C for different time points, showed that KGF induced endocytosis of tyrosine activated KGFRs. The use of KGF-HFc in immunofluorescence and in immunogold electron microscopy on KGFR transfectants, A253 epithelial tumor cells and human cultured keratinocytes allowed us to follow the early steps of KGF internalization and revealed that this process occurred through clathrin-coated pits. A quantitative ELISA assay confirmed that KGF-HFc binding on the cell surface rapidly decreased because of internalization. Our results demonstrate that KGF is internalized by receptor-mediated endocytosis and illustrate the involvement of clathrin-coated pits in this process.
The effects of Ag, Cu compositions and Zn doping on the electromigration performance of Pb-free solders (2009)

A systematic study of the effect of Ag, Cu and Zn alloying elements on the EM performance of Sn-rich Pb-free solder is reported. EM performance was found to strongly depend on the types of UBMs, alloying elements, compositions, and microstructures in solder. While leaded solders were found to be more robust than Pb-free solders, SnAg solders, in general, has better EM performance than SnCu solders. Greater than 1% Ag in SnAg solder is needed to stabilize the Sn grain microstructure and suppress the rapid diffusion process that drives early EM failures. Cu on top of Ni UBM improves the EM reliability. A minor amount of Zn doping in SnAg solder stabilizes both Ag <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn and Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> IMC networks in the solder microstructure and slows down the EM process.
A practical framework of multi-person 3D human pose estimation with a single RGB camera (2021)

We propose a practical framework named 'DN-2DPN-3DPN' for multi-person 3D pose estimation with a single RGB camera. Our framework performs three-stages tasks on the input video: our DetectNet(DN) firstly detects the people's bounding box individually for each frame of the video, while our 2DPoseNet(2DPN) estimates the 2D poses for each person in the second stage, and our 3DPoseNet(3DPN) is finally applied to obtain the 3D poses of the people. Experiments validate that our method can achieve state-of-the-art performance for multi-person 3D human pose estimation on the Human3.6M dataset.
Filtrage spatial robuste à partir d'un sous-ensemble optimal d'électrodes en BCI EEG (2009)

La réalisation d'une interface cerveau machine EEG nécessite généralement l'utilisation d'un grand nombre d'électrodes, causant la gêne de l'utilisateur et augmentant considérablement le coût calculatoire des traitements. Cependant, un choix judicieux de l'emplacement des ces électrodes peut permettre une réduction importante de leur nombre sans perte signiﬁcative en performance. Cet article présente une méthode de sélection automatique d'un sous-ensemble quasi optimal d'électrodes et de ﬁltres spatiaux calculés par Common Spatial Pattern (CSP) . Cette méthode, basée sur un calcul de coefﬁcient de détermination multiple et l'utilisation du critère d'Akaike, est traitée de manière à résister aux artefacts par l'utilisation d'estimateurs robustes de variance et de matrice de covariance . Il est ainsi montré qu'une réduction très importante du nombre d'électrode est possible sans perte d'information sur les caractéristiques spatiales et que cette méthode résiste parfaitement à un grand nombre d'artefacts lorsque les signaux sont corrompus par des artefacts.