gebhart/patrepeval huggingface dataset:
1.52 µm electroluminescence from GaAs-based quantum dot bilayers (2011)

InGaAs strain reducing layers (SRLs) are applied to InAs bilayer quantum dots (QDs) grown by molecular beam epitaxy on GaAs substrates. By control of the QD size and density and the composition of the SRLs, peak ground state electroluminescence of up to 1.52 µm is demonstrated from devices incorporating five QD bilayers, without the need for a metamorphic buffer layer.
Spin-Conserving Resonant Tunneling in Twist-Controlled WSe2-hBN-WSe2 Heterostructures (2018)

We investigate interlayer tunneling in heterostructures consisting of two tungsten diselenide (WSe<sub>2</sub>) monolayers with controlled rotational alignment, and separated by hexagonal boron nitride. In samples where the two WSe<sub>2</sub> monolayers are rotationally aligned we observe resonant tunneling, manifested by a large conductance and negative differential resistance in the vicinity of zero interlayer bias, which stem from energy- and momentum-conserving tunneling. Because the spin-orbit coupling leads to coupled spin-valley degrees of freedom, the twist between the two WSe<sub>2</sub> monolayers allows us to probe the conservation of spin-valley degree of freedom in tunneling. In heterostructures where the two WSe<sub>2</sub> monolayers have a 180° relative twist, such that the Brillouin zone of one layer is aligned with the time-reversed Brillouin zone of the opposite layer, the resonant tunneling between the layers is suppressed. These findings provide evidence that, in addition to momentum, the spin-valley degree of freedom is also conserved in vertical transport.
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes (2021)

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor binding domain (RBD). In one subject, just four IgG lineages accounted for 93.5% of the response, including an amino (N)-terminal domain (NTD)-directed antibody that was protective against lethal viral challenge. Genetic, structural, and functional characterization of a multidonor class of "public" antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. These data show that "public" NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape.
Synthesis and antiproliferative activity of unsaturated quinoline derivatives. (2000)

In our previous work Knoevenagel condensation of quinoline 2-, 3- and 4-carbaldehyde with malononitrile derivatives was used to produce a series of heteroarylidene malononitrile derivatives. Some of these heteroaromatic tyrphostins were potent inhibitors of the epidermal growth factor (EGF) receptor kinase. This work has now been extended by using 6-, 7-, and 8-quinolinecarbaldehyde to prepare 23 new quinoline-tyrphostins 1-23. Most of these compounds were moderately active against the MCF7 breast cancer cell line. The order of potency was 7- > 6 > 8-substituted quinoline, which indicates that increased activity of the 7-substituted quinolines is associated with electron deficiency at the 7-position in the quinoline ring. The most active compound, 12, formed from 7-quinolinecarbaldehyde and ethyl cyanoacetate, had an IC50 value of 2.3 microM. Compounds 1-23 showed similar IC50 values against the MCF7 and MCF7/ADR cell lines (the latter shows fourfold increased protein tyrosine kinase activity) except for the compounds 1 and 15 formed from 6-quinolinecarbaldehyde and malononitrile and 7-quinolinecarbaldehyde and cyanoacetamide, which showed a significant (11- and 42-fold, respectively) increase in potency against the MCF7/ADR cell line. Furthermore, no association was found between growth inhibition and inhibition of the EGFR protein tyrosine kinase (PTK), using a cell-free assay. In addition, new compounds were prepared from 2- and 4-quinolinecarbaldehyde with extended conjugation in the side chains (24-27) or with methoxypolyethoxyethyl esters in the side chain to increase water solubility (28 and 29). These compounds showed substantial cytotoxicity, with IC50 values in the range 1-25 microM, but similar values were observed against both cell lines. No association was found between inhibition of PTK and growth inhibition, again indicating that their mode of action may not be specific for the EGF receptor.
INCLUSION OF [H3PW12O40] AND [H4SiW12O40] INTO A SILICA GEL MATRIX VIA "SOL-GEL" METHODOLOGY (2017)

Here we report the inclusion of two Keggin Polyoxometalates (POMs), [H 3 PW 12 O 40 ] and [H 4 SiW 12 O 40 ], into silica gels by integrating them during the preparation of the SiO 2 matrix via "sol-gel" methods. Aerogels were produced by supercritical drying of the wet gels impregnated with the POMs, and lyogels were obtained by means of a lyophilization process. These materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy and thermoanalytical techniques (TGA-DSC). We found that a large fraction of POMs are lost during the aging time, and solvent exchange for lyophilization. However the thermal stability of the bare matrix is modified by the inclusion of POMs. Some aggregates with a high content of POMs were found via SEM-EDX.
A systematic review of carotid stent design and selection: strategies to optimize procedural outcomes (2013)

Carotid artery stenting is an alternative to carotid endarterectomy in select patients. The stroke and death rate following carotid artery stenting must be reduced to allow more general use of this technology. Online databases were utilized to review the impact of stent design. Results specifically for symptomatic patients were reported by four investigators and these data were pooled. A total of 4352 symptomatic patients were pooled (1892 closed cell and 2460 open cell). The odds ratio when comparing open-cell stents with closed-cell stents was 1.35 (95% CI: 0.99–1.83; p = 0.057) for the end point of a 30-day transient ischemic attack, stroke or death. Symptomatic patients with favorable anatomy may have a reduced 30-day risk of transient ischemic attack, stroke or death when closed-cell stents are utilized.
Low-Threshold-Current and Single-Mode Surface-Emitting Laser Buried in Amorphous GaAs (1996)

We propose a vertical-cavity surface-emitting laser buried in low-temperature-grown amorphous GaAs (a-GaAs), which was found to be effective for surface passivation of an etched cavity and suppression of high-order transverse modes. The deposition of highly resistive a-GaAs layer on an InGaAs/GaAs active region and AlAs/GaAs mirror layers yielded a significant improvement in threshold current density and differential quantum efficiency. The maximum currents maintaining a stable fundamental transverse mode were also increased by the antiguide effect of a-GaAs with a high refractive index. For a 10-µm-diameter device, we attained a stable single-mode emission with a threshold current of 0.7 mA.
Nonconvergent cycloaddition pathways for thermal vs. photochemical reaction of N-isobutenylpyrrolidine with dimethyl fumarate (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonconvergent cycloaddition pathways for thermal vs. photochemical reaction of N-isobutenylpyrrolidine with dimethyl fumarateFrederick D. Lewis, Tong-Ing Ho, and Robert J. DeVoeCite this: J. Org. Chem. 1980, 45, 26, 5283–5286Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://doi.org/10.1021/jo01314a011RIGHTS & PERMISSIONSArticle Views478Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (497 KB) Get e-Alertsclose Get e-Alerts
The role of chemotaxis and efflux pumps on nitrate reduction in the toxic regions of a ciprofloxacin concentration gradient (2021)

Spatial concentration gradients of antibiotics are prevalent in the natural environment. Yet, the microbial response in these heterogeneous systems remains poorly understood. We used a microfluidic reactor to create an artificial microscopic ecosystem that generates diffusive gradients of solutes across interconnected microenvironments. With this reactor, we showed that chemotaxis toward a soluble electron acceptor (nitrate) allowed Shewanella oneidensis MR-1 to inhabit and sustain metabolic activity in highly toxic regions of the antibiotic ciprofloxacin (>80× minimum inhibitory concentration, MIC). Acquired antibiotic resistance was not observed for cells extracted from the reactor, so we explored the role of transient adaptive resistance by probing multidrug resistance (MDR) efflux pumps, ancient elements that are important for bacterial physiology and virulence. Accordingly, we constructed an efflux pump deficient mutant (∆mexF) and used resistance-nodulation-division (RND) efflux pump inhibitors (EPIs). While batch results showed the importance of RND efflux pumps for microbial survival, microfluidic studies indicated that these pumps were not necessary for survival in antibiotic gradients. Our work contributes to an emerging body of knowledge deciphering the effects of antibiotic spatial heterogeneity on microorganisms and highlights differences of microbial response in these systems versus well-mixed batch conditions.
Chemical and Sensory Characterization of Orange (Citrus sinensis) Pulp, a by‐Product of Orange Juice Processing Using Gas‐Chromatography‐Olfactometry (2016)

Abstract Volatile composition of commercial orange pulp (from Brazil and Florida, U.S.A.) was analyzed by gas chromatography‐mass spectrometry (GC‐MS) and GC‐Olfactometry (GC‐O). In both samples 72 volatiles were detected, of which 58 were identified. Odor‐active compounds with a high frequency of detection (≥5 out of 9) or intensity characterizing the aroma of sweet orange pulp were monoterpene hydrocarbons (α‐pinene, β‐pinene, β‐myrcene, α‐phellandrene, 3‐carene, α‐terpinene and limonene), ketones (1‐octen‐3‐one, carvone, ( E )‐β‐damascenone and β‐ionone), esters (ethyl‐2‐methyl butanoate and ethyl hexanoate), aldehydes (methional and octanal), alcohols (linalool and 1‐octanol) and 3 unidentified compounds. A few differences in the odor‐active volatiles between orange pulp samples were perceived, which might be due to cultivar, growing and processing conditions, but overall, the chemical composition of the two samples was similar. Sensory data described both sweet orange pulp samples with descriptors for orange odor and flavor including orange peel and fruity‐non‐citrus flavor, sweet and sour taste. Practical Applications Orange pulp is used in the beverage industry to add texture and mouthfeel. It is also added to orange juice for consumer appeal to make it more “natural.” This study characterized the flavor of orange pulp. Orange pulp consisted of yellow–orange floating intact cells. Pulp added to a sugar‐acid solution (5% pulp, 10.5% sucrose and 0.25% citric acid) imparted an orange, fruity and fresh flavor. Information from this study on sweet orange pulp flavor will be useful for orange juice processors and beverage manufacturers.
Ultra-high frequency photoconductivity decay in GaAs/Ge/GaAs double heterostructure grown by molecular beam epitaxy (2013)

GaAs/Ge/GaAs double heterostructures (DHs) were grown in-situ using two separate molecular beam epitaxy chambers. High-resolution x-ray rocking curve demonstrates a high-quality GaAs/Ge/GaAs heterostructure by observing Pendellösung oscillations. The kinetics of the carrier recombination in Ge/GaAs DHs were investigated using photoconductivity decay measurements by the incidence excitation from the front and back side of 15 nm GaAs/100 nm Ge/0.5 μm GaAs/(100)GaAs substrate structure. High-minority carrier lifetimes of 1.06-1.17 μs were measured when excited from the front or from the back of the Ge epitaxial layer, suggests equivalent interface quality of GaAs/Ge and Ge/GaAs. Wavelength-dependent minority carrier recombination properties are explained by the wavelength-dependent absorption coefficient of Ge.
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions (2021)

β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1) is considered to be a promising target for treating Alzheimer's disease. However, all clinical BACE1 inhibitors have failed due to lack of efficacy, and some have even led to cognitive worsening. Recent evidence points to the importance of avoiding BACE2 inhibition along with careful dose titration. In this study, we focused on the fact that the 10s loop lining the S3 pocket in BACE1 can form both "open (up)" and "closed (down)" conformations, whereas in BACE2, it prefers to adopt a "closed" form; thus, more space is available in BACE1. By leveraging the difference, we designed fused pyridine analogues that could reach the 10s loop, leading to <b>6</b> with high selectivity and significant Aβ reduction. The cocrystal structures confirmed that <b>6</b> significantly increased B-factors of the 10s loop in BACE2 relative to those in BACE1. Thus, the destabilization of BACE2 seems to offer structural insights into the reduced BACE2 potency of <b>6</b>, explaining the significant improvement in BACE1 selectivity.
Supplementary Fig S9 from Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing (2023)

&lt;p&gt;Supplementary Fig S9 and legend&lt;/p&gt;
Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering (2012)

Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better understanding of these remarkable biomechanical membrane properties altered in some pathological states including blood diseases. In particular the discussion over the thermal or metabolic origin of the CMF has led in the past to a large number of investigations and modeling. However, the origin of the CMF is still debated. In this article, we present an analysis of the CMF of RBCs by combining digital holographic microscopy (DHM) with an orthogonal subspace decomposition of the imaging data. These subspace components can be reliably identified and quantified as the eigenmode basis of CMF that minimizes the deformation energy of the RBC structure. By fitting the observed fluctuation modes with a theoretical dynamic model, we find that the CMF are mainly governed by the bending elasticity of the membrane and that shear and tension elasticities have only a marginal influence on the membrane fluctations of the discocyte RBC. Further, our experiments show that the role of ATP as a driving force of CMF is questionable. ATP, however, seems to be required to maintain the unique biomechanical properties of the RBC membrane that lead to thermally excited CMF.
Guanylate Cyclase C Agonists, a New Class of Drug Candidates for Treatment of Inflammatory Bowel Disease (2011)

Purpose: Uroguanylin (UG) is an endogenous peptide secreted into the GI lumen where it binds to guanylate cyclase C receptors (GC-C) and stimulates production of cGMP. Increased prodction of cGMP activates cystic fibrosis transmembrane conductance regulator (CFTR), resulting in enhancement of the transepithelial efflux of sodium, potassium, chloride and water. We previously reported that the expression of UG is dramatically reduced in human colon polyps and in cancerous tissues. Oral treatment with UG also inhibited polyp formation in Apc min/+ mice. Subsequently, we reported that the anticancer and anti-inflammatory activities of GC-C agonists are through downregulation of certain pro-inflammatory cytokines. SP-333 and plecanatide are potent analogs of UG and are resistant to proteolysis by human simulated gastric and intestinal fluids. Thus, purpose of this study was to evaluate antiinflammatory effects of GC-C agonists in murine models of colitis. Methods: Colitis in BALB/c and BDF1 mice was induced either by 2.5% trinitrobenzene sulfonic acid (TNBS) in 50% ethanol administered via catheter into the colonic lumen or by dextran sulfate sodium (DSS) mixed in drinking water. Mice (n=12 per group) were given oral doses of plecanatide or SP-333 between 0.005 to 50 mg/kg/body weight or vehicle PBS for 7 days. On day 7, mice were sacrificed. H&E stained colonic tissue sections were assessed for colitis by a pathologist blinded to treatment group. Tissue sections were also scored for expression of Ki-67. Levels of myeloperoxidase activity was also measured in colon tissue. Intestinal explants were cultured for 24 hours and levels of cytokines were measured in the culture supernatants. Results: In both models, histological assessment of colonic tissue demonstrated significant amelioration of colitis in the plecanatide or SP-333-treated mice as compared to those in the vehicle treated mice (p<0.05). The anti-inflammatory activity of SP-333 at 0.5 mg/kg dose was comparable to the anti-inflammatory activity of 5-aminosalicylic acid (100 mg/kg), used as a positive control in mice. These agonists reduced Ki-67 expression and production of myeloperoxidase, IL-4, IL-5, IL-23 and TNF-α. Conclusion: The treatment with SP-333 or plecanatide ameliorated GI inflammation in TNBS- and DSS-induced colitis in mice, possibly through downregulation of IL-4, IL-5, IL-23, and TNF-α. These results suggest a cGMP-mediated mechanism for the anti-inflammatory action, which opens a novel avenue for development of GC-C agonists as a new class of orally delivered, mucosally active, drug candidates for treatment of GI inflammatory diseases and IBDinduced colorectal cancer. SP has received compensation as a consultant to Synergy Pharmaceuticals, Inc. Disclosure: Dr. Kunwar Shailubhai - Employee of Synergy, Dr. Bradely Nefsky - Employee of IHVR, Dr. Shet Masih - Employee of IHVR, Dr. John Foss - Employee of Synergy, Dr. Stephen Comiskey - Employee of Synergy, Dr. Gary Jacob - Employee of Synergy, Dr. Scott Plevy - Consultant of Synergy.
Interview. Le référendum d’initiative citoyenne fait peur aux élus (2019)

Selon le politologue Patrick Le Lidec, le référendum d’initiative citoyenne cher aux « gilets jaunes » risque de se heurter à l’hostilité des édiles. Et, surtout, il ne s’attaque pas à la cause première de la colère : la hausse des prélèvements et la baisse des prestations pour réduire des déficits et une dette endémiques.
GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells (2011)

Our findings provide information on the role of an alternate growth and survival factor on the acquisition of aromatase inhibitor resistance in ER+ breast cancer.
Fluorine-19 NMR studies of the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-8-(D-ribityl)lumazine and derivatives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorine-19 NMR studies of the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-8-(D-ribityl)lumazine and derivativesMark Cushman, Hemantkumar H. Patel, Johannes Scheuring, and Adelbert BacherCite this: J. Org. Chem. 1993, 58, 15, 4033–4042Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jo00067a041https://doi.org/10.1021/jo00067a041research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oriented Growth of ZnO Crystals on Self-Assembled Monolayers of Functionalized Alkyl Silanes (2003)

Highly ordered ZnO crystals of 0.15 μm width and 0.5 μm length were grown on silicon wafers coated with a monolayer of SiCl3(CH2)11−O−C6H5 molecules. Various techniques (contact angle measurements, ellipsometry, ATR-FTIR) were employed for determining the quality of the monolayer coating. In addition, the bare and silane-coated Si wafers were studied by X-ray reflectivity (XR) and grazing-incidence diffraction (GID) using synchrotron radiation. The results obtained point to a possible relationship between the organization of the self-assembled monolayer (SAM) coating, the dipole moment of the headgroup, and the orientation of the ZnO crystals.
Data from Identification of <i>SULF2</i> as a Novel Transcriptional Target of p53 by Use of Integrated Genomic Analyses (2023)

&lt;div&gt;Abstract&lt;p&gt;Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression profiling, and chromatin immunoprecipitation technologies, we identified a set of 32 direct transcriptional targets of the tumor suppressor p53. Of these 32 genes, 11 are not currently associated with the core p53 pathway. From among these novel pathway members, we focused on understanding the connection between p53 and &lt;i&gt;SULF2&lt;/i&gt;, which encodes an extracellular heparan sulfate 6-&lt;i&gt;O&lt;/i&gt;-endosulfatase that modulates the binding of growth factors to their cognate receptors and that has been shown to function as a tumor suppressor. Genetic and pharmacologic perturbation of p53 directly influences &lt;i&gt;SULF2&lt;/i&gt; expression, and similar to silencing of &lt;i&gt;TP53&lt;/i&gt;, RNA interference–mediated suppression of &lt;i&gt;SULF2&lt;/i&gt; results in an impaired senescence response of cells to genotoxic stress. Thus, our integrated genomic approach has led to the identification of a novel mediator of p53 network biology. [Cancer Res 2009;69(4):1368–74]&lt;/p&gt;&lt;/div&gt;