gebhart/patrepeval huggingface dataset:
SPIMS: a tool for protocol implementation performance measurements (2003)

The authors present SPIMS, a tool which provides an environment where it is easy to develop, specify, and execute communication measurements that can be used for 'benchmarking'. The tool measures user-oriented performance parameters, such as throughput and response time, without relying on special hardware or operating system support. The measurements are specified in a protocol-independent specification language, which is presented in some detail. The usefulness of the tool is demonstrated by measurements on the ISODE OSI (FTAM) stack and the Arpa (FTP/TCP) protocols on Sun, MicroVAX, Apollo, IBM PC/RT and DS90 machines running Unix.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nuclear Emancipation: A Platelet Tour de Force (2010)

Mammalian platelets are anucleate cells produced by the polyploid megakaryocyte. Platelets are more than just key players in hemostasis (blood clotting in response to injury); they also have important roles in inflammation, immunity, tumor progression, and thrombosis. Complex systems of homeostasis have been described for platelets, including posttranscriptional and translational mechanisms to regulate platelet function. Platelets contain transcription factors, and these proteins have essential roles in regulating nongenomic processes. A study provides evidence for a previously unknown negative feedback pathway for limiting platelet activation that occurs through the nuclear factor κB transcription factor family. This pathway is mediated by an adenosine 3',5'-monophosphate-independent protein kinase A activity in response to platelet stimulation. Our appreciation of the role of transcription factors in mammalian platelet biology is nascent but holds great promise for both understanding platelet function and translation into clinical uses.
ChemInform Abstract: Reaction of N2O5 with H2O on Carbonaceous Surfaces. (1986)

Abstract The interaction of gaseous N 2 O 5 with a carbonaceous surface, in both the absence and presence of H 2 O, is investigated in relation to its possible atmospheric importance (collision between gas molecules and particles in a highly polluted urban environment).
Potentiation of antimicrobial photodynamic inactivation by inorganic salts (2017)

Antimicrobial photodynamic inactivation (aPDI) involves the use of non-toxic dyes excited with visible light to produce reactive oxygen species (ROS) that can destroy all classes of microorganisms including bacteria, fungi, parasites, and viruses. Selectivity of killing microbes over host mammalian cells allows this approach (antimicrobial photodynamic therapy, aPDT) to be used in vivo as an alternative therapeutic approach for localized infections especially those that are drug-resistant. Areas covered: We have discovered that aPDI can be potentiated (up to 6 logs of extra killing) by the addition of simple inorganic salts. The most powerful and versatile salt is potassium iodide, but potassium bromide, sodium thiocyanate, sodium azide and sodium nitrite also show potentiation. The mechanism of potentiation with iodide is likely to be singlet oxygen addition to iodide to form iodine radicals, hydrogen peroxide and molecular iodine. Another mechanism involves two-electron oxidation of iodide/bromide to form hypohalites. A third mechanism involves a one-electron oxidation of azide anion to form azide radical. Expert commentary: The addition of iodide has been shown to improve the performance of aPDT in several animal models of localized infection. KI is non-toxic and is an approved drug for antifungal therapy, so its transition to clinical use in aPDT should be straightforward.
Efficient color transformation implementation (2017)

A simple solution would be to precompute the transform for all possible digital inputs and store the corresponding outputs in a lookup table (LUT). Constructing such a LUT involves first defining a lattice of nodes that partition the input color space into a set of smaller subvolumes. An alternative is to build a LUT with a sparser node sampling and to use multidimensional interpolation for input points that do not coincide with the LUT nodes. Three-dimensional interpolation geometries include trilinear, prism, pyramidal, and tetrahedral, in order of decreasing numbers of nodes used. LUT interpolation involves a three-way trade-off among LUT approximation accuracy, storage and memory requirements, and computational complexity. The chapter describes the basic LUT transformation and variants thereof. It discusses algorithms for efficiently processing large amounts of image data through a LUT transformation. The desired color transformation is evaluated at these nodes, and the resulting output values are stored at the node locations.
A 3nm CMOS FinFlex™ Platform Technology with Enhanced Power Efficiency and Performance for Mobile SoC and High Performance Computing Applications (2022)

The industry fastest time-to-manufacturability 3nm CMOS platform technology is presented. FinFlex™ with standard cells consisting of different fin configurations is introduced for the first time to offer the critical design flexibility for better power efficiency and performance optimization compared to traditional FinFET technologies. An aggressive scaling of ~1.6X logic density increase, 18% speed improvement and 34% power reduction are achieved over our previous 5nm CMOS process. This FinFlex™ platform technology provides the best-in-class PPAC values to fully unleash product innovations in 5G and HPC applications.
<title>Similarity pyramids for browsing and organization of large image databases</title> (1998)

The advent of large image databases (&gt; 10,000) has created a need for tools which can search and organize image automatically by their content. This paper presents a method for designing a hierarchical browsing environment which we call a similarity pyramid. The similarity pyramid groups similar images together while allowing users to view the database at varying levels of resolution. We show that the similarity pyramid is best constructed using agglomerative (bottom-up) clustering methods, and present a fast-sparse clustering method which dramatically reduces both memory and computation over conventional methods. We then present an objective measure of pyramid organization called dispersion, and we use it to show that our fast-sparse clustering method produces better similarity pyramids than top down approaches.
Modeling Operational Variability for Robust Multidisciplinay Design Optimization (2017)

International audience
Optimizing Cellular Networks Enabled with Renewal Energy via Strategic Learning (2015)

An important issue in the cellular industry is the rising energy cost and carbon footprint due to the rapid expansion of the cellular infrastructure. Greening cellular networks has thus attracted attention. Among the promising green cellular network techniques, the renewable energy-powered cellular network has drawn increasing attention as a critical element towards reducing carbon emissions due to massive energy consumption in the base stations deployed in cellular networks. Game theory is a branch of mathematics that is used to evaluate and optimize systems with multiple players with conflicting objectives and has been successfully used to solve various problems in cellular networks. In this paper, we model the green energy utilization and power consumption optimization problem of a green cellular network as a pilot power selection strategic game and propose a novel distributed algorithm based on a strategic learning method. The simulation results indicate that the proposed algorithm achieves correlated equilibrium of the pilot power selection game, resulting in optimum green energy utilization and power consumption reduction.
Data from Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but is overexpressed in carcinomas of the gastrointestinal tract, the genitourinary and respiratory systems, and breast cancer. As such, CEACAM5 is an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs to certain epithelial tumors. Here, we describe preclinical data for a novel antibody–drug conjugate (ADC), SAR408701, which consists of an anti-CEACAM5 antibody (SAR408377) coupled to a maytansinoid agent DM4 via a cleavable linker.&lt;/p&gt;Experimental Design:&lt;p&gt;The specificity and binding affinity of SAR408701 to human and cynomolgus monkey CEACAM5 were tested &lt;i&gt;in vitro&lt;/i&gt;. The cytotoxic activity of SAR408701 was assessed in CEACAM5-expressing tumor cell lines and using patient-derived xenograft mouse models of CEACAM5-positive tumors. Pharmacokinetic-pharmacodynamic and pharmacokinetic-efficacy relationships were established. SAR408701 toxicity was evaluated in cynomolgus monkey.&lt;/p&gt;Results:&lt;p&gt;SAR408701 bound selectively to human and cynomolgus monkey CEACAM5 with similar apparent Kd values (0.017 nmol/L and 0.024 nmol/L, respectively). Both &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; evaluations showed that SAR408701 has cytotoxic activity, leading to &lt;i&gt;in vivo&lt;/i&gt; efficacy in single and repeated dosing. Single doses of SAR408701 induced significant increases in the tumor expression of phosphorylated histone H3, confirming the tubulin-targeting mechanism of action. The overall toxicity profile of SAR408701 in cynomolgus monkey was similar to that observed after intravenous administration of DM4 alone.&lt;/p&gt;Conclusions:&lt;p&gt;On the basis of these preclinical data, the ADC SAR408701 is a promising candidate for development as a potential treatment for patients with CEACAM5-positive tumors.&lt;/p&gt;&lt;/div&gt;
The MAP3S Static-and-Regular Mesh Simulation and Wavefront Parallel-Programming Patterns (2008)

This paper presents the simulation and wavefront parallel-programming patterns of the MAP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> S pattern-based parallel programming system for distributed-memory environments. Both patterns target iterative computations on static-and-regular meshes. In addition to providing performance-oriented features, such as asynchronous communication and distribution of the computational workload that is tailored to fit the computation, the patterns also provide usability-oriented features, such as direct mesh-access, mesh memory-footprint distribution, and a versatile data-dependency specification scripting-language. Parallel programs developed using MAP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> S achieve significant performance gains and capability enhancements on both low-end and high-end interconnect-equipped distributed-memory systems.
Epidemiology of periprosthetic fracture of the femur in 32 644 primary total hip arthroplasties (2016)

Intra-operative fractures occur 14 times more often with uncemented stems, particularly with female patients over 65 years of age, while post-operative fracture risk is independent of age or gender, but still increased with uncemented stems.
DSP-based on-line NMR spectroscopy using an anti-Hebbian learning algorithm (2002)

This paper describes a nuclear magnetic resonance (NMR) system that uses an adaptive algorithm to carry out real-time NMR spectroscopy in chemical contents characterisation. The system employs a digital signal processor chip to regulate the transmitted and received signal together with spectral analysis of the received signal to determine free induction decay (FID). To implement such a signal-processing routine for detection of the desired signal, an adaptive line enhancer filter that uses an anti-Hebbian learning algorithm is applied to the FID spectra. The results indicate that the adaptive filter can be a reliable technique for on-line spectroscopy study.
HYPOCAPNEA IMMEDIATELY AFTER ROSC IS ASSOCIATED WITH GOOD NEUROLOGIC OUTCOME IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST (2006)

s Translations: Abstracts from the 16th Pediatric Critical Care Colloquium: Oral Abstract Presentations
RESEARCH OF A POLYMER BASE FOR CREATING AN ELECTRICALLY CONDUCTIVE GRAPHITE PASTE FOR MEDICAL PURPOSES (2021)

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A Readily Available and User-Friendly Chiral Catalyst for Efficient Enantioselective Olefin Metathesis (2001)

Hier braucht man keine Handschuhbox mehr! Aus kommerziell erhältlichen Ausgangsverbindungen kann ein neuer Katalysator für die Olefin-Metathese hergestellt werden, der mindestens so wirkungsvoll und selektiv wie die bisher bekannten ist. Dieser benutzerfreundliche Katalysator wird in situ hergestellt (siehe Schema), eine Isolierung ist nicht nötig, es kann ohne Handschuhbox gearbeitet werden, und es werden Reaktivitäten und Enantiomerenüberschüsse erzielt, die bisher nur mit einer mehrfachen Katalyse erreicht werden konnten.
Schedulability Analysis for a Mode Transition in Real-Time Multi-core Systems (2013)

To enable real-time systems to adapt to dynamically changing environments, update functionalities and/or accommodate those tasks migrated from other failed sub-systems, there have been a number of studies on making timing guarantees while accounting for change of parameters and addition/deletion of tasks. While most of them have dealt with "transition" protocols that delay next task releases or discard the unfinished tasks released before the transition, such protocols are not suitable for many control systems in which missing/delaying control updates (by completing periodic tasks) even during a transition or mode-change may cause system instability or incur a significant incremental operational cost. In this paper, we focus on a transition protocol that does not miss/delay control updates during a system transition, and develop a new schedulability analysis for the transition in a real-time multi-core system, which provides sufficient timing guarantees without requiring any online information, such as the release and execution patterns of tasks and the start time of a transition. To achieve this, we extend an existing popular schedulability analysis framework for nontransitional tasks, and identify the scenarios that maximize the duration of a task's interference to another task in the case of a transition. Since the analysis works for any arbitrary transition order of tasks, we can improve the schedulability performance by enforcing a specific order. We formulate the problem of assigning an optimal transition order, and develop a solution by deriving some properties of optimality. Our evaluation results demonstrate that the proposed solution finds more schedulable task sets, which are not covered by naive approaches.
A new BML-based RANS modelling for the description of gas turbine typical combustion processes (2004)

The work is concentrated on the formulation and validation of integral models within RANS framework for the numerical prediction of the premixed and partially premixed flames occurring in gas turbine combustors. The premixed combustion modelling is based on the BML approach coupled to the mixing transport providing variable equivalence ratio. Chemistry is described by means of ILDM model solving transport equations for reaction progress variables conditioned on the flame front. Multivariate presumed PDF model is used for the turbulence-chemistry interaction treatment. Turbulence is modelled using the second moment closure (SMC) and the standard κ-ε model as well. The influence of non-gradient turbulent transport is investigated comparing the gradient diffusion closure and the solution of the scalar flux transport equations. Different model combinations are assessed simulating several premixed and partially premixed flame configurations and comparing results to the experimental data. The proposed model provides good predictions particularly in combination with SMC.
Low-Complexity RLS Algorithms for the Identification of Bilinear Forms (2018)

The identification of bilinear forms is a challenging problem since its parameter space may be very large and the adaptive filters should be able to cope with this aspect. Recently, the recursive least-squares tailored for bilinear forms (namely RLS-BF) was developed in this context. In order to reduce its computational complexity, two versions based on the dichotomous coordinate descent (DCD) method are proposed in this paper. Simulation results indicate the good performance of these algorithms, with appealing features for practical implementations.
Large Language and Text-to-3D Models for Engineering Design Optimization (2023)

The current advances in generative AI for learning large neural network models with the capability to produce essays, images, music and even 3D assets from text prompts create opportunities for a manifold of disciplines. In the present paper, we study the potential of deep text-to-3D models in the engineering domain, with focus on the chances and challenges when integrating and interacting with 3D assets in computational simulation-based design optimization. In contrast to traditional design optimization of 3D geometries that often searches for the optimum designs using numerical representations, such as B-Spline surface or deformation parameters in vehicle aerodynamic optimization, natural language challenges the optimization framework by requiring a different interpretation of variation operators while at the same time may ease and motivate the human user interaction. Here, we propose and realize a fully automated evolutionary design optimization framework using Shap-E, a recently published text-to-3D asset network by OpenAI, in the context of aerodynamic vehicle optimization. For representing text prompts in the evolutionary optimization, we evaluate (a) a bag-of-words approach based on prompt templates and Wordnet samples, and (b) a tokenisation approach based on prompt templates and the byte pair encoding method from GPT4. Our main findings from the optimizations indicate that, first, it is important to ensure that the designs generated from prompts are within the object class of application, i.e. diverse and novel designs need to be realistic, and, second, that more research is required to develop methods where the strength of text prompt variations and the resulting variations of the 3D designs share causal relations to some degree to improve the optimization.
Pixelated dual module GYGAG directional gamma spectrometer (2021)

We report on a small gamma spectrometer with directional detection, based on two modules. Each module contains an array of 128 scintillator pixels coupled to reverse-biased photodiodes, an ASIC and a microcontroller. Modules communicate via USB and are operated via an Android GUI on a WiFi-connected device. Transparent ceramic GYGAG ((Gd,Y,Ce)3(Ga,Al)5O12) garnet scintillator pixels offer energy resolution as good as 3.1% at 662 keV for individual pixels. We previously reported on an eight-module planar spectrometer, based on the same technology1. The current compact system uses two modules in a back-to-back configuration to improve its speed and accuracy in locating a gamma-emitting source in a 4-pi field of view. This dual module system (~2.5 x 2.5 x 3.5 inches) is suitable as a pager-sized RIID or spectroscopic personal radiation detector (SPRD). Multiple dual module units can be combined for improved efficiency. Spectroscopic and directional performance will be described.
Protective relay faceplate development utilizing the benefits of IEC 61850 (2013)

This paper outlines the procedure and guidelines used to create Human Machine Interface (HMI) faceplates for industrial control systems that represent protective relays. The faceplates are developed around an IEC 61850 enabled network and represent a structured, industry accepted, HMI format. Background and benefits of the IEC 61850 standard are also discussed.
Electrolysis of Water in the Secondary School Science Laboratory with Inexpensive Microfluidics (2014)

This activity allows students to visualize the electrolysis of water in a microfluidic device in under 1 min. Instructional materials are provided to demonstrate how the activity meets West Virginia content standards and objectives. Electrolysis of water is a standard chemistry experiment, but the typical laboratory apparatus (e.g., Hoffman cell) is best suited for group presentations. With microfluidics, the cell volume is reduced from 100 mL to 100 μL, making the electrolysis safer and easier to view by an individual. A single device is reusable and assembled for $5. This report describes the development of a microfluidic learning module that was implemented and assessed in the eighth-grade chemistry classroom.
An offset compensated class-AB sample-and-hold amplifier using two sampling capacitors (2008)

A new circuit topology of an offset compensated class-AB sample-and-hold (S/H) amplifier using two sampling capacitors is described. Conventional class-AB S/H amplifiers have high power efficiency, but suffer from offset deviations of the internal amplifier. The proposed class-AB S/H amplifier is free from the offset deviation of the internal amplifier, while achieving high power efficiency comparable to conventional class-AB S/H amplifiers. Simulation results show that systematic offset of the proposed S/H amplifier is comparable to that of an offset-compensated class-A S/H amplifier and has faster settling speed than that of the class-A type amplifier.
Issues in designing a neutral genotype-phenotype mapping (2003)

This paper discusses issues that arise when a redundant genotype-phenotype mapping is used in the context of a real-world application. Previous studies have suggested that a redundant mapping, which introduces neutrality into the search space, can provide a beneficial role. Many of the studies to date have concentrated on relatively abstract search spaces. In this paper we consider these issues in the context of a specific real-world application. We show that redundancy can indeed be useful, but that it must be carefully introduced with due consideration to details of the application being considered, and its associated search space. Although the details of the redundant encoding are specific to the application, we seek to deduce some heuristics that are likely to prove useful for designing genetic encodings for other problems to facilitate search for fitter phenotypes.
MP28-20 KIDNEY CANCER WELLNESS DETERMINANT (KCWD) AN ADJUNCTIVE TOOL TO PREDICT SURVIVAL IN RENAL CELL CARCINOMA (2018)

associated with hereditary renal cancer. While 50 individuals (5.3%) were found to have a PV in a gene not previously associated with hereditary renal cancer, 39 (78%) reported a history of a second non-renal primary tumor. A personal history of >1 renal cancer was reported for 98 (10.4%) individuals. Among these, 12 (12.2%) were found to have a PV in ATM, BAP1, CHEK2, FH (3), MET, MITF, WT1, SDHA, TSC1, and VHL. Individuals with >1 renal cancer who tested positive (41.2 yrs) tended to be diagnosed at a younger age compared to those who tested negative (49.8 yrs) (p0.085). Among those reporting a single primary renal cancer, the yield was 7.4% (21/284), and the average age at diagnosis was not significantly different between those testing positive (42.0 yrs) and those testing negative (44.2 yrs) (p0.544). When assessing family history, 178 (18.8%) reported a family history of renal cancer; 20 (11.2%) were found to have a PV.