gebhart/patrepeval huggingface dataset:
Diet, Monoamine Neurotransmitters and Appetite Control (2001)

This article has attempted to point out some of the relationships between 5-HT and catecholamine (NE, DA) neurons in brain and the control of appetite and food intake. At least two bodies of evidence support this connection. The first is pharmacologic, and demonstrates that drugs that stimulate transmission across 5-HT and/or catecholamine synapses suppress hunger and food intake. The second is physiologic and metabolic, and reveals that the ingestion of foods, on either an acute (single meal) or chronic basis, can reliably modify the uptake of TRP and TYR into brain (and hypothalamus), and directly alter the synthesis of their transmitters (5-HT and the catecholamines, respectively). The synthesis of these two bodies of information has led to models by which (1) changes in dietary carbohydrate ingestion, by modifying brain TRP uptake and 5-HT production, may cause like changes in 5-HT release, and in the stimulation of 5-HT receptors in brain circuits that control carbohydrate appetite, and (2) dietary protein intake, by altering brain TYR uptake, directly influences DA and NE synthesis (notably in hypothalamus), perhaps providing a signal to brain circuits monitoring dietary protein adequacy regarding protein intake. In this case, one might imagine that stimulating DA and/or NE receptors in such circuits might suppress protein intake, a possibility we are now examining in rats. As indicated in the Introduction, the broader issue being touched upon in this article concerns the body's need to acquire and maintain an optimal (or adequate) nutritional balance (for growth and ultimately, reproductive success). Rats and humans evolved in an environment that does not provide continuous access to all essential nutrients, and one that presents nutrients in a complex matrix (other animals, plants) that can also include toxic compounds. Together with the fact that animals and humans do not carry a guidebook to healthy eating, we must presume that the brain mechanisms that have evolved to optimize the acquisition of essential nutrients are 'automatic' (i.e., not conscious) and quite complex. In this context, the relationships described here must be viewed as rudimentary, touching only a small portion of this complex regulatory mechanism. The hope is, as further insights develop, that we will gain a better understanding of the workings of these mechanisms, and also be able to apply this knowledge to the development of better pharmacologic (and other) aids for controlling appetite and obesity in our modern, man-made environment.
CT-Pathologic Correlation of Major Types of Pulmonary Fibrosis: Insights for Revisions to Current Guidelines (2018)

The purpose of this study was to assess the diagnostic significance of CT patterns that cannot be classified according to current idiopathic pulmonary fibrosis (IPF) guidelines and of specific findings of the inconsistent with usual interstitial pneumonitis (UIP) pattern.Subjects with a multidisciplinary diagnosis of interstitial lung disease who had undergone surgical lung biopsy and chest CT within 1 year of each other were included in the study. The predominant distribution and pattern of disease were scored. Cases were classified as UIP, possible UIP, or inconsistent with UIP at chest CT according to 2011 IPF guidelines. Cases that could not be confidently categorized with current guidelines were annotated as indeterminate.UIP, possible UIP, and inconsistent with UIP CT patterns were associated with pathologic UIP in 89.6%, 81.6%, and 60.0% of subjects. An indeterminate CT pattern (7.7% [20/259]) was associated with a UIP pathologic diagnosis in 55.0% of cases. This finding was not statistically different from the findings in the group with the inconsistent with UIP CT pattern (p = 0.677) but was different from the findings in the UIP (p < 0.001) and possible UIP (p = 0.031) groups. In regard to specific findings of the inconsistent with UIP CT category, ground-glass opacity, air-trapping, consolidation, and axial distribution were associated with a non-UIP pathologic diagnosis; however, there was no significant association with zonal distribution.A substantial minority of cases cannot be confidently categorized according to current guidelines for IPF and differ diagnostically from the possible UIP and UIP CT categories. The term "inconsistent with UIP" is misleading and should be renamed.
Risk factors during pregnancy and birth‐related complications in HIV‐positive versus HIV‐negative women in Denmark, 2002–2014 (2019)

WLWH had more risk factors present during pregnancy, similar risks of most pregnancy- and birth-related complications but a higher risk of postpartum haemorrhage and EmCS compared with WGP. Children born to WLWH had lower median birth weights and gestational ages and were at higher risk of IUGR.
Performance Evaluation of Additional Parity for L1 Signaling in ATSC 3.0 (2019)

This paper investigates the performance gain of additional parity which can be employed for improving the robustness of physical layer [layer-1 (L1)] signaling (L1 signaling) in Advanced Television Systems Committee (ATSC) 3.0. Its performance gain is evaluated in the view point of additional coding gain and diversity gain with extensive computer simulations. We first evaluate the coding gain with the aid of capacity analysis over AWGN channel, and then the diversity gain is evaluated over TU-6 channel based on the ATSC 3.0 frame structure. Numerical results show that additional parity gives significant performance gain under mobile environments.
41.1: Development of RGBw LCD with Edge Lit 2D Local Dimming System for Automotive Applications (2015)

We have developed 10‐inch RGBW LCD with edge‐lit 2D local dimming backlight system for automotive applications. This prototype system has power consumption reduction performance of 41.5% compared to a conventional RGB display without local dimming backlight. The performance and evaluation results are described in this paper.
The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel (2014)

In glaucoma, aqueous outflow into the Schlemm's canal (SC) is obstructed. Despite striking structural and functional similarities with the lymphatic vascular system, it is unknown whether the SC is a blood or lymphatic vessel. Here, we demonstrated the expression of lymphatic endothelial cell markers by the SC in murine and zebrafish models as well as in human eye tissue. The initial stages of SC development involved induction of the transcription factor PROX1 and the lymphangiogenic receptor tyrosine kinase VEGFR-3 in venous endothelial cells in postnatal mice. Using gene deletion and function-blocking antibodies in mice, we determined that the lymphangiogenic growth factor VEGF-C and its receptor, VEGFR-3, are essential for SC development. Delivery of VEGF-C into the adult eye resulted in sprouting, proliferation, and growth of SC endothelial cells, whereas VEGF-A obliterated the aqueous outflow system. Furthermore, a single injection of recombinant VEGF-C induced SC growth and was associated with trend toward a sustained decrease in intraocular pressure in adult mice. These results reveal the evolutionary conservation of the lymphatic-like phenotype of the SC, implicate VEGF-C and VEGFR-3 as critical regulators of SC lymphangiogenesis, and provide a basis for further studies on therapeutic manipulation of the SC with VEGF-C in glaucoma treatment.
User Adaptation Of Convolutional Neural Network For Human Activity Recognition (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
Conformational and acid-base equilibriums of captopril in aqueous solution (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational and acid-base equilibriums of captopril in aqueous solutionDallas L. Rabenstein and Anvarhusein A. IsabCite this: Anal. Chem. 1982, 54, 3, 526–529Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ac00240a039https://doi.org/10.1021/ac00240a039research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Refining the Methodology to Correct the Faraday Rotation Angle from SMOS Measurements (2019)

In this work, a refined methodology to correct the Faraday Rotation angle (FRA) for the SMOS mission is proposed. The method is based on calculating the FRA using the SMOS full-pol radiometric data to obtain VTEC maps applying spatiotemporal filtering techniques, to then making possible the compensation of the FRA effect. By this way, the FRA would be corrected from the data that is measuring the satellite and not using an external database.
Detecting Drug-Drug Interactions using Protein Sequence-Structure Similarity Networks (2021)

Adverse drug events represent a key challenge in public health, especially with respect to drug safety profiling and drug surveillance. Drug-drug interactions represent one of the most popular types of adverse drug events. Most computational approaches to this problem have used different types of data, such as drug chemical structure, information about protein targets, side effects, pathways, etc to predict potential interactions between drugs. In this work, we study the question of whether using just genetic information about the drugs can provide significant information about the potential safety profile for a given drug. We propose a novel neural network model to predict adverse drug events using only data about the protein sequence and protein structure associated with the drug targets. We compare the results with those from the state-of-the-art methods on this problem. Our results show that the proposed method is quite competitive, at times outperforming the state-of-the-art.
Information Sharing for Distributed Planning (Extended Abstract) (2010)

Large-scale collaborative planning is critical in many domains such as sensor networks and disaster rescue. In large, heterogeneous multiagent teams, agents must work together to create plans that maximize the effectiveness of the team as a whole; coordinating actions to increase efficiency while also avoiding potentially dangerous interactions between teammates. Recognizing the utility of information to agents in teams and delivering it efficiently across a team has also been the focus of much research, with proposed approaches ranging from classic flooding, gossiping, to channel filtering. We combine these two fields of research to study the problem of information sharing mechanisms to distribute planning in both certain and uncertain environments.
The usage of new antipsychotics in treatment of schizophrenia with obsessive-compulsive symptoms (2011)

Background Obsessive-compulsive (OC) symptoms have been observed in a substantial proportion of schizophrenic patients. Different etiopathological origins of OC symptoms make this type of schizophrenia to be a heterogeneous entity in phenomenological as well as in therapeutic aspects. The complex nature of the treatment response in this group of schizophrenic patients is as yet unclear. Methods We present a large case series study describes our experience with clozapine, risperidone, olanzapine, quetiapine, ziprazidone, amisulpiride, sertindole and paliperidone as a sole agents and in combination with serotonin reuptake inhibitors (SRIs) in patients with OCD-schizophrenia (n = 55) and schizo-obsessive disorder (n = 64). Results In patients with OCD-schizophrenia treatment with atypicals (other than clozapine), the better results (significant reduction of OC as well as schizophrenia symptoms) were achieved in combination with SRIs, while olanzapine showed the fastest overall improvement. In schizo-obsessive patients, treatment with atypicals (including clozapine) as monotherapy was the better therapeutic modality, and the risperidone showed the best results. Quetiapine, amisulpiride, sertindole, paliperidone and ziprazidone (as sole agents and with SRIs) were shown as approximately equal in their antipsychotic and antiobsessive activity and overall safety. Conclusions The effects of different atypicals (with/without SRIs) on psychotic and OC symptoms are vary, probably due to different origin of OC symptoms. We suggest that: 1) schizo-obsessive patients might be successfully treated with atypicals alone; 2) in OCD-schizophrenia atypicals monotherapy may be less efficient, and in some cases may worsen OC symptoms, so it should be treated concomitantly with SRIs. Further investigations are needed to substantiate our observations.
Future of Thermal Management of High End Video Cards in ATX and BTX (2005)

The present study aims to examine the future of the thermal management of video cards in PC systems. The primary focus of this investigation is on high end video card applications in both the ATX and BTX platforms. In this article, the thermo-mechanical architecture of these platforms will be revealed along with a discussion of the power density road map of both the graphics processing unit (GPU) and video processor unit (VPU) expected to be in use until the year 2010. Recommendations of how to extend the air cooling limit for video cards in either the ATX or BTX platforms will be part of the conclusions of this study.
Periodic Mesoporous Dendrisilicas (2004)

We report the synthesis of a new class of materials called periodic mesoporous dendrisilicas. They are prepared from dendrimers with trialkoxysilyl groups at the outmost shell. Dendrimers of various cores and numbers of shells are used. The dendrisilica synthesis is based on acid- or base-catalyzed hydrolysis of the trialkoxysilyl groups and subsequent template-directed condensation of the dendrimers into an ordered template-dendrisilica nanocomposite. The template can be removed with organic solvents, producing a periodic mesoporous dendrisilica whose pore walls consist of interconnected dendrimer building blocks.
Live Demonstration: KAUSTat — A Compact Reconfigurable Electrochemical Station (2022)

This live demonstration presents a novel compact reconfigurable electrochemical station that can be used with different types of screen-printed electrodes (SPE) and laser-scribed graphene-based (LSG) sensors. The device presented here is named as KAUSTat. The proposed system includes rich circuit architecture that allows the reconfiguration of its output pins to be used for different purposes. The device can be used to read electrochemical sensors by applying voltammetry and amperometry techniques, and it also can be used to modify the surface of SPEs and LSGs.
The estrogen receptor-α A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study (2005)

This population-based study, the largest so far to screen for the ER-alpha A908G mutation in breast cancer, confirms the presence of the mutant in invasive breast tumors. The mutation was associated with higher tumor grade and mixed lobular/ductal breast tumor histology.
Levitation of ordinary diamagnets at room temperature (1991)

The passive diamagnetic levitation of pyrolytic graphite can take place in magnetic fields of approximately 1 T. This is at a field strength less than half that claimed for certain diamagnetic salts. Moreover, at these field strengths, levitation can be induced by the fields of ordinary room temperature electromagnets or high energy product permanent magnets.
Distributed Domain Generation Based on the Network Environment Characteristics for Dynamic Ad-Hoc Networks (2004)

Ad hoc networks are very important for scenarios where there is not fixed network infrastructure. These scenarios may appear both in the military and the commercial world. Even though there is much advancement in the area of these networks, the main drawback is that ad hoc networks do not scale well because the existing protocols (e.g., MAC, routing, security) cannot tolerate their dynamics. A remedy to this problem could exist if these protocols were applied in hierarchical manner. The hierarchy generation in these dynamic environments can be advantageous since the numerous topological changes can be tolerated easier and the various protocols can perform better when dealing with smaller groups of nodes. On the other hand, hierarchy has to be generated carefully in order to be beneficial for the network otherwise it may harm it, because of the imposed maintenance overhead. The weakness of the existing network clustering algorithms is that they do not take into consideration the dynamics of the network environment, so in cases of increased mobility their overhead may deteriorate network performance instead of improving it. In this paper we present a new dynamic distributed clustering (DDC) algorithm. The basic characteristic of this algorithm is that it takes into consideration the network dynamics for the generation of robust and efficient clusters. DDC can be applied in highly mobile networks and we show that it presents better scalability and robustness characteristics from well known existing clustering algorithms.
Targeting a Complex Transcriptome: The Construction of the Mouse Full-Length cDNA Encyclopedia (2003)

We report the construction of the mouse full-length cDNA encyclopedia,the most extensive view of a complex transcriptome,on the basis of preparing and sequencing 246 libraries. Before cloning,cDNAs were enriched in full-length by Cap-Trapper,and in most cases,aggressively subtracted/normalized. We have produced 1,442,236 successful 3'-end sequences clustered into 171,144 groups, from which 60,770 clones were fully sequenced cDNAs annotated in the FANTOM-2 annotation. We have also produced 547,149 5' end reads,which clustered into 124,258 groups. Altogether, these cDNAs were further grouped in 70,000 transcriptional units (TU),which represent the best coverage of a transcriptome so far. By monitoring the extent of normalization/subtraction, we define the tentative equivalent coverage (TEC),which was estimated to be equivalent to >12,000,000 ESTs derived from standard libraries. High coverage explains discrepancies between the very large numbers of clusters (and TUs) of this project,which also include non-protein-coding RNAs,and the lower gene number estimation of genome annotations. Altogether,5'-end clusters identify regions that are potential promoters for 8637 known genes and 5'-end clusters suggest the presence of almost 63,000 transcriptional starting points. An estimate of the frequency of polyadenylation signals suggests that at least half of the singletons in the EST set represent real mRNAs. Clones accounting for about half of the predicted TUs await further sequencing. The continued high-discovery rate suggests that the task of transcriptome discovery is not yet complete.
Crowding in context (2013)

In peripheral vision, objects that can be readily recognized when viewed in isolation, become unrecognizable in clutter. This is the interesting phenomenon known as visual crowding. Crowding represents an essential bottleneck, setting limits on object perception, eye movements, visual search, reading and perhaps other functions in peripheral, amblyopic and developing vision (Whitney & Levi, 2011). It is generally defined as the deleterious influence of nearby contours on visual discrimination, but the effects of crowding go well beyond impaired discrimination. Crowding impairs the ability to recognize and respond appropriately to objects in clutter. Thus, studying crowding may lead to a better understanding of the processes involved in object recognition. Crowding also has important clinical implications for patients with macular degeneration, amblyopia and dyslexia. Crowding is strongly dependent on context. The focus of this talk will be on trying to put crowding into context with other visual phenomena. Meeting abstract presented at VSS 2013
Gender and renal function influence plasma levels of copeptin in healthy individuals (2008)

The present study sought to identify confounding factors for the interpretation of copeptin levels in healthy individuals. The natriuretic peptides are recognized as diagnostic and prognostic tools in HF (heart failure). Interpretation of BNP (brain natriuretic peptide) and NTproBNP (N-terminal pro-BNP) levels is multifaceted as their secretion is influenced by many variables. A newly identified glycopeptide called copeptin is comparable with the natriuretic peptides in the diagnosis and prognosis of HF and as a prognostic biomarker after AMI (acute myocardial infarction). Copeptin, derived from the C-terminal portion of the precursor to AVP (arginine vasopressin), is secreted stoichiometrically with vasopressin, hence it can be used as a surrogate marker of the AVP system. In the present study, 706 healthy volunteers were recruited from a local HF screening study. Participants with a history of cardiovascular disease and those with echocardiographic abnormalities were excluded from the study. Copeptin and NTproBNP levels were assayed using in-house immunoluminometric assays. Median copeptin levels were significantly higher in the male volunteers compared with the females [median (range): 4.3 (0.4-44.3) compared with 3.2 (1.0-14.8) pmol/l; P<0.001]. In males, copeptin was correlated with eGFR (estimated glomerular filtration rate; r(s)=-0.186, P<0.001). In females, the correlation of copeptin with eGFR was weak (r(s)=-0.097, P=0.095). DT (deceleration time) and left atrial size correlated with higher copeptin levels (r(s)=0.085, P=0.029 and r(s)=0.206, P<0.001 respectively). Only gender (P<0.001), eGFR (P<0.001), left atrial size (P=0.04) and DT (P=0.02) remained independently predictive of plasma copeptin. The present study suggests that gender and renal function specific partition values should be used to interpret copeptin values in future studies of this biomarker in HF or ischaemic heart disease.