gebhart/patrepeval huggingface dataset:
Simulation and Analysis of Transient Fuel Cell System Performance Based on a Dynamic Reactant Flow Model (2002)

Fuel cell stack systems are under intensive development by several manufacturers since they complement heat engines and reduce the ubiquitous dependence on fossil fuels and thus have significant environmental and national security implications. To compete with ICE engines, however, fuel cell system must operate and function at least as well as conventional engines. Transient behavior is on of the key requirements for the success of fuel cell vehicles. The fuel cell system power response depends on the air and hydrogen feed, flow and pressure regulation, and heat and water management. During transient, the fuel cell stack control system is required to maintain optimal temperature, membrane hydration, and partial pressure of the reactants across the membrane in order to avoid degradation of the stack voltage, and thus, efficiency reduction. In this paper, we developed a fuel cell system dynamic model suitable for control study. The transient phenomena captured in the model include the flow characteristics and inertia dynamics of the compressor, the manifold filling dynamics (both anode and cathode), and consequently, the time-evolving reactant partial pressures, and membrane humidity. The effects of varying oxygen concentration and membrane humidity on the fuel cell voltage were included. Simulation results are presented to demonstrate the model capability.
Quantifying Leak Rates in Gas Handling Systems (2008)

Gas-handling systems, subassemblies, and components constructed from metals and plastics alike need to be tested for pressure loss and leakage. In this study, the concept of conductance or characteristic leak rate has been further developed for pressurized scenarios and applied to a model system. Conductance was measured from both pressure-decay experiments and from constant pressure-flow experiments using three different gases at three different temperatures. Results from the two types of tests were compared using an analysis developed as part of this study. Conductance values from decay and steady-state measurements were in general agreement. Thus, in the evaluation of real components, subassemblies, or systems, conductance can be estimated from a simple pressure-decay measurement and then used to estimate steady-state performance.
Compact relay lenses using microlenslet arrays (2002)

In an investigation of approaches to compact relay lenses for special effect photography, the potential of microlenslet arrays in image formation is investigated. In this paper, various arrangements of microlenslet arrays and associated baffles are considered and their role on image quality presented. Findings through software simulations clearly demonstrate the trade-offs between image quality and compactness.
Novel Amidinating Cross-Linker for Facilitating Analyses of Protein Structures and Interactions (2010)

A novel bifunctional thioimidate cross-linking reagent (diethyl suberthioimidate) that modifies amines without sacrificing their native basicity is developed. Intermolecular cross-linking of neurotensin and intramolecular cross-linking of cytochrome c under physiological conditions is investigated with this reagent. Because it does not perturb the electrostatic properties of a protein, it is unlikely to lead to artifactual conclusions about native protein structure. The interpeptide cross-links formed with this reagent are easily separated from other tryptic fragments using strong cation exchange chromatography, and they have a readily identified mass spectrometric signature. The use of this novel amidinating protein cross-linking reagent holds great promise for efficient, large-scale structural analysis of complex systems.
Phthalide annulation: the synthesis of kalafungin, pachybasin and chrysophanol (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhthalide annulation: the synthesis of kalafungin, pachybasin and chrysophanolGeorge A. Kraus, Hidetsura Cho, Steven Crowley, Bruce Roth, Hirohiko Sugimoto, and Susan PrughCite this: J. Org. Chem. 1983, 48, 20, 3439–3444Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/jo00168a013https://doi.org/10.1021/jo00168a013research-articleACS PublicationsRequest reuse permissionsArticle Views759Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Inhibitors of Inducible NO Synthase Expression: Total Synthesis of (S)‐Curvularin (Ia) and Its Ring Homologues. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Methods, Figure Legends 1-6 from Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies (2023)

&lt;p&gt;PDF file - 119K, Detailed description of the Supplementary Materials and Methods, Experimental 4T1.2 in vivo Data and Figure Legends&lt;/p&gt;
Distributed metadata servers for cluster file systems using shared low latency persistent key-value metadata store (2023)

A cluster file system is provided having a plurality of distributed metadata servers with shared access to one or more shared low latency persistent key-value metadata stores. A metadata server comprises an abstract storage interface comprising a software interface module that communicates with at least one shared persistent key-value metadata store providing a key-value interface for persistent storage of key-value metadata. The software interface module provides the key-value metadata to the at least one shared persistent key-value metadata store in a key-value format. The shared persistent key-value metadata store is accessed by a plurality of metadata servers. A metadata request can be processed by a given metadata server independently of other metadata servers in the cluster file system. A distributed metadata storage environment is also disclosed that comprises a plurality of metadata servers having an abstract storage interface to at least one shared persistent key-value metadata store.
Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus (2020)

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that follows an unpredictable disease course and affects multiple organs and tissues. We performed an integrated, multicohort analysis of 7,471 transcriptomic profiles from 40 independent studies to identify robust gene expression changes associated with SLE. We identified a 93-gene signature (SLE MetaSignature) that is differentially expressed in the blood of patients with SLE compared with healthy volunteers; distinguishes SLE from other autoimmune, inflammatory, and infectious diseases; and persists across diverse tissues and cell types. The SLE MetaSignature correlated significantly with disease activity and other clinical measures of inflammation. We prospectively validated the SLE MetaSignature in an independent cohort of pediatric patients with SLE using a microfluidic quantitative PCR (qPCR) array. We found that 14 of the 93 genes in the SLE MetaSignature were independent of IFN-induced and neutrophil-related transcriptional profiles that have previously been associated with SLE. Pathway analysis revealed dysregulation associated with nucleic acid biosynthesis and immunometabolism in SLE. We further refined a neutropoiesis signature and identified underappreciated transcripts related to immune cells and oxidative stress. In our multicohort, transcriptomic analysis has uncovered underappreciated genes and pathways associated with SLE pathogenesis, with the potential to advance clinical diagnosis, biomarker development, and targeted therapeutics for SLE.
Zinc Oxide Nanowire Photodetectors with Single-Walled Carbon Nanotube Thin-Film Electrodes (2012)

In this study, transparent and flexible zinc oxide (ZnO) nanowire ultraviolet (UV) photodetectors prepared via a solution-based method in which single-walled carbon nanotube (SWNT) thin films were used as transparent electrodes are reported. The photoresponse current was found to be in proportion with the ZnO nanowire density, and the nanowire density could be tuned to increase the photocurrent by a factor of 300. The decay time for the fabricated photodetectors was found to be as low as 16 s. This study suggests the possibility of fabricating inexpensive, visible-blind UV photodetectors via solution-based methods.
MatPlanner (2017)

Nowadays multi-track conferences impose great difficulty to attendees in making a day plan of attending relevant sessions/papers, because a large number of sessions are scheduled on a single day and many of them are at the same time. To address this problem, we introduce MatPlanner, a mobile application, which provides an alternate way of scheduling a day in a conference by understanding the attendee's interest and preferences. MatPlanner learns event-topic interest matrix from few sampled events selected by each user and then recommend relevant events and display the final output. More importantly, MatPlanner's interface enables users to resolve conflicting events by showing them at the same panel which makes it easy to compare. Interview results suggested a high level of satisfaction among participants in scheduling a day.
Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner (2019)

Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis. Herein, we show that soluble CD83 (sCD83) enhances the resolution of autoimmune antigen-induced arthritis (AIA) by strongly reducing the expression levels of cytokines such as IL-17A, IFNγ, IL-6, and TNFα within the joints. Noteworthy, also the expression of RANKL, osteoclast differentiation, and joint destruction was significantly inhibited by sCD83. In addition, osteoclasts which were cultured in the presence of synovial T cells, derived from sCD83 treated AIA mice, showed a strongly reduced number of multinuclear large osteoclasts compared to mock controls. Enhanced resolution of arthritis by sCD83 was mechanistically based on IDO, since inhibition of IDO by 1-methyltryptophan completely abrogated sCD83 effects on AIA. Blocking experiments, using anti-TGF-β antibodies further revealed that also TGF-β is mechanistically involved in the sCD83 induced reduction of bone destruction and cartilage damage as well as enhanced resolution of inflammation. Resolution of arthritis was associated with increased numbers of regulatory T cells, which are induced in a sCD83-IDO-TGF-β dependent manner. Taken together, sCD83 represents an interesting approach for downregulating cytokine production, inducing regulatory T cells and inducing resolution of autoimmune arthritis.
Power Mobility Training for a 7-Month-Old Infant with Spina Bifida (2009)

These results suggest that power mobility training within the first year of life may be appropriate for certain populations at risk of immobility.
Identification of novel small molecule Beclin 1 mimetics activating autophagy (2017)

Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free out Beclin 1, and thus trigger autophagy. In order to identify small molecule Beclin 1 mimetics, a fluorescence polarization-based high-throughput screening of 50,316 compounds was carried out with a Z' score of 0.82 ± 0.05, and an outcome of 58 hits. After the structure analysis, three acridine analogues were unveiled and confirmed using the fluorescence polarization assay and the surface plasmon resonance assay. Moreover, a set of 17 additional acridine analogues was prepared and tested. Compound 7 showed selectivity for Bcl-xL (<i>K<sub>D</sub></i> = 6.5 μM) over Bcl-2 (<i>K<sub>D</sub></i> = 160 μM) protein, and potent cytotoxicity (nanomolar scale) in PC-3, PC-3a and DU145 prostate cancer cells. Furthermore, induction of autophagy was also demonstrated in PC-3 and PC-3a cells treated with some acridine compounds by LC3 conversion immunoblotting and LC3 fluorescence microscopy. These Beclin 1 mimetics will be invaluable tools for developing novel autophagy inducers, better understanding the roles of autophagy in cancer, and will contribute to cancer therapy.
Immunohistochemical and biochemical analysis of serotonin and substance P colocalization in the nucleus tractus solitarii and associated afferent ganglia of the rat (1988)

In a previous study of afferent projections to the nucleus tractus solitarii (NTS), it was shown that over half of the retrogradely-labelled neurons in the nucleus raphe pallidus contained serotonin-immunoreactivity and over half of these neurons contained substance P-immunoreactivity, suggesting that these two putative neurotransmitters are colocalized in NTS-afferent neurons. The objectives of the present study were to 1) directly determine if varicosities in the NTS, the area postrema (AP), and the dorsal motor nucleus of the vagus nerve (DMN) do contain both transmitters, 2) determine if primary afferent neurons in the nodose and pretrosal ganglia might also colocalize serotonin and substance P, and 3) quantify the amount of substance P that is contained in serotonergic varicosities in the NTS. Distributions and colocalization of substance P and serotonin in the NTS were studied using dual-color immunohistochemistry, while the quantity of substance P in serotonergic varicosities was assessed by radioimmunoassay (RIA) using micropunches from the NTS of 5,7-dihydroxytryptamine-(5,7 DHT-) and vehicle-treated rats. Varicosities that contained both serotonin- and substance P-immunoreactivity were found in the NTS, the DMN, and the AP. Double-labelled varicosities were common in the NTS and DMN (i.e., qualitatively similar to the density seen in the hypoglossal nucleus and in the ventral horn of the cervical spinal cord); however, the vast majority of the varicosities in these autonomic areas only displayed immunoreactivity for one or the other of these transmitters. This paucity of doubly-labelled varicosities, in comparison to the number of singly-labelled varicosities, was reflected in the lack of a significant decrease in substance P levels as determined by RIA of micropunches taken from caudal and intermediate levels of the NTS in 5,7 DHT- and vehicle-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Development of a pilot‐scale 1 for Legionella elimination in biofilm in hot water network: heat shock treatment evaluation (2009)

This work could help water managers for a better management of water network and for a better control of Legionella.
Activation of TRPA1 on dural afferents: A potential mechanism of headache pain (2012)

Activation of transient receptor potential ankyrin-1 (TRPA1) on meningeal nerve endings has been suggested to contribute to environmental irritant-induced headache, but this channel may also contribute to other forms of headache, such as migraine. The preclinical studies described here examined functional expression of TRPA1 on dural afferents and investigated whether activation of TRPA1 contributes to headache-like behaviors. Whole-cell patch-clamp recordings were performed in vitro with 2 TRPA1 agonists, mustard oil (MO), and the environmental irritant umbellulone (UMB) on dural-projecting trigeminal ganglion neurons. Application of MO and UMB to dural afferents produced TRPA1-like currents in approximately 42% and 38% of cells, respectively. By means of an established in vivo behavioral model of migraine-related allodynia, dural application of MO and UMB produced robust time-related tactile facial and hind paw allodynia that was attenuated by pretreatment with the TRPA1 antagonist HC-030031. Additionally, MO or UMB were applied to the dura, and exploratory activity was monitored for 30min with an automated open-field activity chamber. Dural MO and UMB decreased the number of vertical rearing episodes and the time spent rearing in comparison to vehicle-treated animals. This change in activity was prevented in rats pretreated with HC-030031 as well as sumatriptan, a clinically effective antimigraine agent. These data indicate that TRPA1 is expressed on a substantial fraction of dural afferents, and activation of meningeal TRPA1 produces behaviors consistent with those observed in patients during migraine attacks. Further, they suggest that activation of meningeal TRPA1 via endogenous or exogenous mechanisms can lead to afferent signaling and headache.
Abstract 48 (2012)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration (2023)

Following acute injury, the capillary vascular bed in the lung must be repaired to reestablish gas exchange with the external environment. Little is known about the transcriptional and signaling factors that drive pulmonary endothelial cell (EC) proliferation and subsequent regeneration of pulmonary capillaries, as well as their response to stress. Here, we show that the transcription factor Atf3 is essential for the regenerative response of the mouse pulmonary endothelium after influenza infection. <i>Atf3</i> expression defines a subpopulation of capillary ECs enriched in genes involved in endothelial development, differentiation, and migration. During lung alveolar regeneration, this EC population expands and increases the expression of genes involved in angiogenesis, blood vessel development, and cellular response to stress. Importantly, endothelial cell-specific loss of Atf3 results in defective alveolar regeneration, in part through increased apoptosis and decreased proliferation in the endothelium. This leads to the general loss of alveolar endothelium and persistent morphological changes to the alveolar niche, including an emphysema-like phenotype with enlarged alveolar airspaces lined with regions that lack vascular investment. Taken together, these data implicate Atf3 as an essential component of the vascular response to acute lung injury that is required for successful lung alveolar regeneration.
Volume Assessment in Mechanically Ventilated Critical Care Patients Using Bioimpedance Vectorial Analysis, Brain Natriuretic Peptide, and Central Venous Pressure (2010)

Purpose. Strategies for volume assessment of critically ill patients are limited, yet early goal-directed therapy improves outcomes. Central venous pressure (CVP), Bioimpedance Vectorial Analysis (BIVA), and brain natriuretic peptide (BNP) are potentially useful tools. We studied the utility of these measures, alone and in combination, to predict changing oxygenation. Methods. Thirty-four mechanically ventilated patients, 26 of whom had data beyond the first study day, were studied. Relationships were assessed between CVP, BIVA, BNP, and oxygenation index (O(2)I) in a cross-sectional (baseline) and longitudinal fashion using both univariate and multivariable modeling. Results. At baseline, CVP and O(2)I were positively correlated (R = 0.39; P = .021), while CVP and BIVA were weakly correlated (R = -0.38; P = .025). The association between slopes of variables over time was negligible, with the exception of BNP, whose slope was correlated with O(2)I (R = 0.40; P = .044). Comparing tertiles of CVP, BIVA, and BNP slopes with the slope of O(2)I revealed only modest agreement between BNP and O(2)I (kappa = 0.25; P = .067). In a regression model, only BNP was significantly associated with O(2)I; however, this was strengthened by including CVP in the model. Conclusions. BNP seems to be a valuable noninvasive measure of volume status in critical care and should be assessed in a prospective manner.
Measuring Fermionic Entanglement - Entropy and Negativity (2018)

The recent direct experimental measurement of quantum entanglement paves the way towards a better understanding of many-body quantum systems and their correlations. Nevertheless, the experimental and theoretical advances had so far been predominantly limited to bosonic systems. Here, we study fermionic systems. Using experimental setups where multiple copies of the same state are prepared, arbitrary order Renyi entanglement entropies and entanglement negativities can be extracted by utilizing spatially-uniform beam splitters and on-site occupation measurement. As an example, we simulate the use of our protocols for measuring the entanglement growth following a local quench. We also illustrate how our paradigm could be used for experimental quantum simulations of fermions on manifolds with nontrivial spin structures.
Nanoparticles of Pd on Hybrid Polyoxometalate−Ionic Liquid Material: Synthesis, Characterization, and Catalytic Activity for Heck Reaction (2010)

By partial exchange of surface protons of a polyoxometalate (POM; H5PO40V2Mo10) by an ionic liquid (IL; butylmethylimidazolium, bmim+), a protonic IL-POM ([bmim]4HPO40V2Mo10) was obtained. Further exchange of this material with Pd2+ yields a final solid that HRTEM and EXAFS-XANES techniques show to be formed by very regular nanoparticles of PdO with ∼2 nm diameter, which are supported on 1 μm particles of IL-POM hybrid material. The PdO nanoparticles can be easily reduced to Pd, and the resultant material is an active and selective catalyst for the Heck reaction. The catalyst can be recycled, though metal leaching occurs in polar solvents. This can be an interesting material for performing Pd-catalyzed reactions in nonpolar solvents or for working in gas-phase reactions.
Revamping the Cloth Tailoring Pipeline at Pixar (2022)

This work presents the most recent updates to the cloth tailoring pipeline at Pixar. We start by reviewing the evolution of cloth authoring tools used at Pixar from 2001 to the present day. Motivated by previous approaches, we introduce a structured workflow for cloth tailoring that manages multiple mesh versions concurrently. In our implementation, artists interact primarily with a low-resolution quad-dominant mesh, which defines the garment look as well as setups for rigging and simulation. Our system then converts this coarse input model into a triangulated mesh for simulation and a quadrangulated subdivision surface for rendering. To this end, we developed a new remeshing tool that outputs surface triangulations with adaptive resolution and conforming to edge constraints. We also devised procedural routines to generate render meshes by applying fold-over thickness, refining the mesh, and inserting seams. In addition, we introduced a suite of algorithms for transferring input attributes onto the derived meshes, including UV shells, face colors, crease edges, and vertex weights. Our revamped pipeline was deployed on Pixar’s feature films Turning Red and Lightyear, producing hundreds of high-quality garment meshes.