gebhart/patrepeval huggingface dataset:
Stratégie thérapeutique de chimiothérapie néoadjuvante du cancer bronchique non à petites cellules: intérêt de la gemcitabine (2001)

Stages of non-small cell lung cancer (NSCLC) that are potential candidates for surgical resection have been treated in several ways: surgery alone is curative in only two-thirds of cases and post-operative radiotherapy (RT) provides only weak control of advanced-stage disease. Since metastatic recurrence is due to the presence of micrometastases, chemotherapy (CT) can be envisaged, even at an early stage of the disease—first with the CT/RT induction combination, which improves survival (median survival: 15 months) and the resection rate (70%). Recent studies on neoadjuvant therapy have evaluated the usefulness of different induction CT regimens. Among these, the gemcitabine/cisplatin study protocol (GC), set up in a phase II study for patients with stage IIIA N2 NSCLC, was very effective [objective response (OR): 70.2%; median survival: 19 months] and should be promising for stages IB and II. Other studies involving platinum analogs have shown good OR rates inducing a high resection rate and a reduction in the spread to mediastinal lymph nodes. Major studies are ongoing, one of which compares GC + surgery versus surgery alone (stages IB-IIIA); the other regimen aims to evaluate GC versus paclitaxel/carboplatin as well as two induction strategies. Les stades potentiellement résécables du cancer bronchique non à petites cellules (CBNPC) ont connu plusieurs approches de traitement: la chirurgie seule n'est curative que dans deux tiers des cas, la radiothérapie (RT) post-opératoire n'apporte qu'un faible contrôle des stades avancés. Les rechutes métastatiques étant dues à la présence de micrométastases, la chimiothérapie (CT) est alors envisagée même aux stades précoces. Tout d'abord avec l'association CT/RT d'induction qui améliore la survie (médiane de survie: 15 mois) et le taux de résection (70 %). Des études récentes sur le traitement néoadjuvant ont évalué I'intérêt de différents schémas de CT d'induction. Parmi eux le protocole gemcitabine/cisplatine (GC) mis en place dans une étude de phase II pour des patients aux stade IIIA N2 du CBNPC est très efficace [réponse objective (RO): 70,2 %; médiane de survie: 19 mois] et devrait être encourageant pour les stades IB et II. D'autres essais à base de platine ont montré de bons taux de RO induisant un taux de résection élevé et une réduction de I'envahissement des ganglions médiastinaux. Deux études importantes sont en cours dont I'une compare GC + chirurgie versus chirurgie seule (stades IB-IIIA); I'autre schéma visant à évaluer GC versus paclitaxel/carboplatine ainsi que deux stratégies d'induction.
Chopped rate-to-digital FM gyroscope with 40ppm scale factor accuracy and 1.2dph bias (2018)

Present implementations of MEMS gyroscopes measure rate indirectly by first converting it to a displacement [1,2]. In this case, the scale factor is a complex function of the transducer and readout circuits. Changes of any of the underlying parameters result in measurement errors.
Supplementary Information from <i>In Vivo</i> Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing (2023)

&lt;p&gt;Supplementary Methods and Figure Legends.&lt;/p&gt;
Development of a Mid-infrared tunable optical- parametric-oscillator employing a QPM Crystal for MALDI in Mass Spectrometry (2005)

A wavelength tunable OPO 2.6-4.0μm was developed for MALDI application. An output idler energy over 100 μJ with 100 Hz was demonstrated with a slope efficiency of 67.2% employing a 2 mm-thick MgO:PPSLT.
Supplementary Data from Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers (2023)

&lt;p&gt;Supplemental tables and figures as referenced in the manuscript.&lt;/p&gt;
The ultrasound appearance of radiation-induced hepatic injury. Correlation with computed tomography and magnetic resonance imaging. (1988)

The ultrasound findings in three cases of radiation-induced hepatic injury are described and compared with computed tomography and magnetic resonance imaging findings. Fatty infiltration of the liver was present in two of the cases in which concurrent chemotherapy was being administered. On ultrasound B-scans, the regions of radiation injury were hypoechoic relative to the remainder of the liver. This finding was more obvious in the patients with fatty livers. CT scans on the patients with fatty infiltrated livers showed higher attenuation in the irradiated region than in unexposed liver. In the patient where no fatty infiltration was present, the radiated section of liver had lower attenuation consistent with previous reports. Magnetic resonance imaging showed decreased signal in the exposed areas on T1 weighted images.
Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia. (1998)

Hyperglycaemia and hyperinsulinaemia were induced in rats by a continuous 48-h infusion with glucose. Discontinuation of glucose infusion resulted in marked, persistent hypoglycaemia. To further delineate the mechanism underlying this condition, we measured counterregulatory hormone levels, in vivo glucose kinetics (glucose production = rate of appearance = Ra; glucose utilization = rate of disappearance = Rd), and in vitro gluconeogenesis during the 48-h postinfusion period. Prior to cessation of glucose infusion, Rd was increased 6-fold when compared to control rats, whereas Ra was totally abolished. During the first hour after the end of glucose infusion, Ra increased and Rd decreased (but was still higher than Ra), inducing hypoglycaemia which stabilized after 1 h at ¿¿126¿¿3.5 mmol/l when both Ra and Rd became equal. Despite hypoglycaemia, plasma glucagon and catecholamine levels did not increase during the 3-to 36-h time interval. The increase in Ra during the first hour post-infusion was not related to changes in counterregulatory hormone response. The increase in glucose production was accounted for by glycogenolysis, as shown by total depletion in liver glycogen within 6 h and thereafter by gluconeogenesis. In vitro experiments using isolated hepatocytes suggested that gluconeogenesis was supported during the first 24 h by substrates entering the pathway beyond the step catalysed by the PEPCK enzyme. Thereafter, lactate became the major substrate, and this condition was associated with a progressive rise in glucagon concentration. It is concluded that 48 h of hyperglycaemia/hyperinsulinaemia resulted in a failure of counterregulatory hormonal response to hypoglycaemia. Yet, despite this lack of counterregulatory response, hepatic gluconeogenesis was stimulated in response to hypoglycaemia.
Propeller Cavitation Breakdown Analysis (2005)

A Reynolds-averaged Navier-Stokes computational model of homogeneous multiphase flow is presented. Cavitation driven thrust and torque breakdown over a wide range of advance ratios is modeled for an open propeller. Computational results are presented as a form of validation against water tunnel measured thrust and torque breakdown for the propeller. Successful validation of the computational model is achieved. Additional observations are made with regards to cavity size and shape as well as cavitation breakdown behavior.
Enhanced Electrochemical Performance of LiMn0.75Fe0.25PO4 Nanoplates from Multiple Interface Modification by Using Fluorine-Doped Carbon Coating (2017)

We report a novel composite of fluorine-doped carbon-decorated LiMn0.75Fe0.25PO4 (LMFP) nanoplates synthesized via a facile method by using hybrid sucrose and polyvinylidene fluoride as carbon and fluorine sources. In the composite, the thin LMFP nanoplates expose large amounts of (010) crystal face which shortens the Li+ ion diffusion distance. Also, the fluorine-doped carbon coating layer can provide a sufficient pathway for rapid electron transport, and the partially formed metal fluorides in the interface between the LMFP nanoplates surface and fluorine-doped carbon coating layer will help reduce charge transfer resistance. Because of this unique structure, the resulting product exhibits a superior discharge capacity of 162.2 mA h g–1 at the 1 C current rate, and the capacity is retained 94.8% over 200 cycles. Furthermore, this material also can deliver a reversible capacity of 130.3 mA h g–1 at an ultrahigh current rate of 20 C, in which the discharge procedure can be accomplished only in 144 s. The celerity and cycling capability of the prepared material endow it with great potential for application in high performance lithium-ion batteries.
Rapid MALDI‐TOF molecular imaging: Instrument enhancements and their practical consequences (2019)

A new high performance linear MALDI-TOF mass spectrometer provides both high spatial resolution and high speed. This instrument employs a new ion optics system with a grounded ion source and efficient transfer and detection of ions over a broad mass range. This provides very high sensitivity, precision, and an extended dynamic range for both positive and negative ion detection. Here we demonstrate the capabilities of this system by imaging pancreatic tissue samples from rats and mice.
FaceBaker: Baking Character Facial Rigs with Machine Learning (2020)

Character rigs are procedural systems that deform a character’s shape driven by a set of rig-control variables. Film quality character rigs are highly complex and therefore computationally expensive and slow to evaluate. We present a machine learning method for approximating facial mesh deformations which reduces rig computations, increases longevity of characters without rig upkeep, and enables portability of proprietary rigs into a variety of external platforms. We perform qualitative and quantitative evaluations on hero characters across several feature films, exhibiting the speed and generality of our approach and demonstrating that our method out performs existing state-of-the-art work on deformation approximations for character faces.
Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control. (1992)

The effect of metformin treatment was studied in 13 patients with noninsulin-dependent diabetes mellitus (NIDDM), whose fasting plasma glucose concentration was greater than 10 mmol/L with maximal sulfonylurea doses. Patients were studied before and 3 months after receiving 2.5 g/day metformin. The fasting plasma glucose concentration (12.4 +/- 0.8 vs. 8.8 +/- 0.7 mmol/L), mean hourly postprandial plasma glucose concentration from 0800-1600 h (14.0 +/- 1 vs. 9.4 +/- 0.9 mmol/L), and glycosylated hemoglobin level (12.3 +/- 0.6% vs. 9.0 +/- 0.6%) were all significantly (P less than 0.005-0.001) lower after the administration of metformin. The improvement in glycemic control was associated with a 24% increase (P less than 0.05) in insulin-stimulated glucose uptake during glucose clamp studies and a 16% decrease in basal hepatic glucose production (P less than 0.05). Mean hourly concentrations of plasma insulin (411 +/- 73 vs. 364 +/- 73 pmol/L) and FFA concentrations (440 +/- 31 vs. 390 +/- 40 mumol/L) were also lower after 3 months of metformin treatment. However, neither insulin binding nor insulin internalization by isolated monocytes changed in response to metformin. Finally, plasma triglyceride, very low density lipoprotein triglyceride, and very low density lipoprotein cholesterol were significantly decreased (P less than 0.01-0.001), and high density lipoprotein cholesterol was significantly increased (P less than 0.001) after metformin treatment. Thus, the addition of metformin to sulfonylurea-treated patients with NIDDM not in good glycemic control significantly lowered fasting and postprandial plasma glucose concentrations, presumably due to the combination of enhanced glucose uptake and decreased hepatic glucose production. Since the dyslipidemia present in these patients also improved, the results suggest that metformin may be of significant clinical utility in patients with NIDDM not well controlled with sulfonylurea compounds.
EPIDEMIOLOGY OF DRY EYE SYNDROME. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
A method for determining a transmission line pulse shape that produces equivalent results to human body model testing methods (2002)

Electrostatic discharge (ESD) is responsible for more than 25% of semiconductor device and chip damage each year. This paper focuses on an ESD event resulting from the charge being transferred from a human body to an integrated circuit (i.e. the human body model, HBM). In particular, the study provides simulation and experimental results to determine the main mechanism governing the failure of MOS devices subjected to the HBM stress. Based on this mechanism, the correct pulse needed to measure the HBM ESD characteristics using the transmission line pulse (TLP) technique is also determined and recommended.
First-Principles Theory of Hydrogen Diffusion in Aluminum (2008)

Ab initio molecular dynamics simulations are used to obtain the activation enthalpy and preexponential factor for the lattice diffusion of hydrogen in aluminum between the temperatures 650 and 850 K: DeltaH double dagger=0.12+/-0.02 eV and D0=1.8 x 10(-7)m2/s. Vacancies are found to significantly decrease the apparent diffusivity due to their ability to bind one, two, or even six hydrogen atoms, causing a strong composition dependence and non-Arrhenius behavior of the effective diffusion coefficient.
Engineering Intracellularly Retained Gaussia Luciferase Reporters for Improved Biosensing and Molecular Imaging Applications (2017)

Gaussia luciferase (GLUC) is a bioluminescent reporter protein of increasing importance. As a secretory protein, it has increased sensitivity in vitro and in vivo (∼20 000-fold, and ∼1000-fold, respectively) over its competitor, secreted alkaline phosphatase. Unfortunately, this same advantageous secretory nature of GLUC limits its usefulness for many other possible intracellular applications, e.g., imaging signaling pathways in intact cells, in vivo imaging, and in developing molecular imaging biosensors to study protein-protein interactions and protein folding. Hence, to widen the research applications of GLUC, we developed engineered variants that increase its intracellular retention both by modifying the N-terminal secretory signal peptide and by tagging additional sequences to its C-terminal region. We found that when GLUC was expressed in mammalian cells, its N-terminal secretory signal peptide comprising amino acids 1-16 was essential for GLUC folding and functional activity in addition to its inherent secretory property. Modification of the C-terminus of GLUC by tagging a four amino acid (KDEL) endoplasmic reticulum targeting peptide in multiple repeats significantly improved its intracellular retention, with little impact on its folding and enzymatic activity. We used stable cells expressing this engineered GLUC with KDEL repeats to monitor chemically induced endoplasmic reticulum stress on cells. Additionally, we engineered an apoptotic sensor using modified variants of GLUC containing a four amino acid caspase substrate peptide (DEVD) between the GLUC protein and the KDEL repeats. Its use in cell culture resulted in increased GLUC secretion in the growth medium when cells were treated with the chemotherapeutic drugs doxorubicin, paclitaxel, and carboplatin. We thus successfully engineered a new variant GLUC protein that is retained inside cells rather than secreted extracellularly. We validated this novel reporter by incorporating it in biosensors for detection of cellular endoplasmic reticulum stress and caspase activation. This new molecularly engineered enzymatic reporter has the potential for widespread applications in biological research.
Figure S5 from JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Figure S5. The effect of rhOSM on cell viability. Three NSCLC cell lines were treated by rhOSM (10 ng/ml) for 1week and then cell viability were measured by MTT assay.&lt;/p&gt;
Supervised Prediction for Radio Network Planning Tool Using Measurements (2006)

This paper presents an efficient scheme to enhance the simulation results of a radio network planning tool by means of measurements. A multilayer perceptron (MLP) is trained to learn the mapping between the measurements and the simulations. The major contribution is the utilisation of independent component analysis (ICA) that transforms the inputs of the MLP into statistically independent variables and makes the complexity of MLP tractable. Other contributions consist of the use of the k-means clustering algorithm on the incoming data and the enrichment of the training data to enhance the generalization capability of the MLP. The proposed method is applied to a 3G mobile network to enhance the predictions of uplink (UL) and downlink (DL) base station loads. After a training performed on a given network configuration, mechanical antenna tilts are modified and we show that the results obtained by the supervised predictions are much closer to measurements than simulation results for cases that have not been encountered before
Shear wave propagation in complex sub wavelength tissue geometries: Theoretical and experimental implications in the framework of cornea and skin shear wave imaging (2010)

Quantitative measurements of cornea and skin biomechanical properties have many applications in medicine. In ophthalmology, it could lead to a better diagnosis of pathologies or monitoring of treatments. In dermatology, it could help the skin lesions removal monitoring. In the framework of Supersonic Shear Imaging (SSI), these organs are characterized by their complex sub wavelength geometry (thin plate and thin capsule) that strongly influences the shear wave propagation. In this work, a theoretical framework is proposed and validated in experiments for the quantification of elastic modulus in these layered tissues. Shear wave dispersion induced by the guided propagation in such thin layers is estimated and fitted to the analytical dispersion curve derived from the "leaky" Lamb Wave theory. SSI is refined and used in order to map in real time the tissues elasticity. This technique consists in generating a shear wave by ultrasonic radiation force and imaging its propagation through the medium at a high frame rate (20 kHz). For infinite media the shear wave velocity is then linked to the Young's modulus. In cornea and skin layers, the high-frequency shear wave (from 500 to 2000 Hz) is guided similarly to a Lamb wave, with plate thickness (<;1 mm) close to its wavelength. Experimental dispersion curves have been confronted to numerical studies. First, finite differences simulations were performed to obtain numerical dispersion curves in plates with exactly known thickness and elasticity. Besides, theoretical dispersion equations were derived by solving numerically the propagation equation. Dispersion curves obtained in vitro on phantoms are found consistent with analytical calculations. Least mean squares fitting of curves enables to recover a quantitative assessment of elasticity (standard deviation <; 10%).
Nuclear Factor of Activated T Cells Regulates Neutrophil Recruitment, Systemic Inflammation, and T-Cell Dysfunction in Abdominal Sepsis (2014)

The signaling mechanisms regulating neutrophil recruitment, systemic inflammation, and T-cell dysfunction in polymicrobial sepsis are not clear. This study explored the potential involvement of the calcium/calcineurin-dependent transcription factor, nuclear factor of activated T cells (NFAT), in abdominal sepsis. Cecal ligation and puncture (CLP) triggered NFAT-dependent transcriptional activity in the lung, spleen, liver, and aorta in NFAT-luciferase reporter mice. Treatment with the NFAT inhibitor A-285222 prior to CLP completely prevented sepsis-induced NFAT activation in all these organs. Inhibition of NFAT activity reduced sepsis-induced formation of CXCL1, CXCL2, and CXCL5 chemokines and edema as well as neutrophil infiltration in the lung. Notably, NFAT inhibition efficiently reduced the CLP-evoked increases in HMBG1, interleukin 6 (IL-6), and CXCL5 levels in plasma. Moreover, administration of A-285222 restored sepsis-induced T-cell dysfunction, as evidenced by markedly decreased apoptosis and restored proliferative capacity of CD4 T cells. Along these lines, treatment with A-285222 restored gamma interferon (IFN-γ) and IL-4 levels in the spleen, which were markedly reduced in septic mice. CLP-induced formation of regulatory T cells (CD4(+) CD25(+) Foxp3(+)) in the spleen was also abolished in A-285222-treated animals. All together, these novel findings suggest that NFAT is a powerful regulator of pathological inflammation and T-cell immune dysfunction in abdominal sepsis. Thus, our data suggest that NFAT signaling might be a useful target to protect against respiratory failure and immunosuppression in patients with sepsis.
Vasohibins encode tubulin detyrosinating activity (2017)

Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of the C-terminal tyrosine of ⍺-tubulin. The enzymes responsible for detyrosination, an activity first observed 40 years ago, have remained elusive. We applied a genetic screen in haploid human cells to find regulators of tubulin detyrosination. We identified SVBP, a peptide that regulates the abundance of vasohibins (VASH1 and VASH2). Vasohibins, but not SVBP alone, increased detyrosination of ⍺-tubulin, and purified vasohibins removed the C-terminal tyrosine of ⍺-tubulin. We found that vasohibins play a cell type-dependent role in detyrosination, although cells also contain an additional detyrosinating activity. Thus, vasohibins, hitherto studied as secreted angiogenesis regulators, constitute a long-sought missing link in the tubulin tyrosination cycle.
ChemInform Abstract: Ring Syntheses of the Four N‐Methylprotoporphyrin Isomers and of Related N‐Methyl and N,N′‐Dimethylporphyrins. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Efficacy and safety of oral immunotherapy for peanut, cow's milk, and hen's egg allergy: A systematic review of randomized controlled trials (2023)

We found strong evidence that peanut, hen's egg, and cow's milk OIT can induce DS and some evidence for remission. There was a high risk of allergic reactions. Generalizability to the entire food allergic population is not known.
Eaton Agent Pneumonia— Clinical Features (1961)

The clinical features of Eaton agent pneumonia, adenovirus pneumonia, and a group of etiologically undiagnosed viral pneumonias were compared. Eaton agent pneumonia was found to be an acute febrile illness characterized by cough, fever, chills, headache, and malaise. The duration of illness in untreated patients averaged between 2 and 3 weeks. Clinical findings in the other viral pneumonias were milder with less systemic symptoms, less pulmonary involvement, and shorter duration. It was not possible to distinguish Eaton agent pneumonia from the other types on the basis of clinical findings alone, without recourse to the fluorescent antibody test. However, the development of cold agglutinins suggested a diagnosis of Eaton agent pneumonia since they appeared in 49 of 109 patients with this illness, but were infrequently found in other viral pneumonias.