gebhart/patrepeval huggingface dataset:
Comparison of Real World Outcomes of Adalimumab and Infliximab for Patients With Moderate or Severe Ulcerative Colitis in the United States (2015)

Introduction: The anti-tumor necrosis factor (TNF) agents adalimumab (ADA) and infliximab (IFX) are approved for treating moderate to severe UC. We aimed to compare real-world effectiveness and UC-related healthcare resource utilization between anti-TNF-naïve patients initiating ADA or IFX by severity in the US. Methods: A retrospective chart review was conducted to evaluate real-world effectiveness (symptoms and disease activity) and UC-related healthcare resource utilization (hospitalization and surgery rates) among adults with moderate or severe UC initiating ADA or IFX during the time period of 10/1/2012 to 4/1/2014. Eligibility criteria included: age ≥18 years; confirmed UC diagnosis; ADA or IFX initiation on/after 1 October 2012; no prior anti-TNF therapy, history of Crohn's disease, or colectomy; and ≥6 months of follow-up. Moderate and severe UC were defined as a baseline partial Mayo score of 3-5 and 6-9, respectively. Data were assessed separately for patients with moderate and severe UC. Chi-square and Wilcoxon rank-sum tests were used to compare clinical outcomes between groups. Kaplan-Meier curves were used to compare time to remission for each therapy during the first 6 months of follow-up. Negative binomial regressions were used to compare UC-related healthcare resource utilization during follow-up between groups. Results: Both ADA- and IFX-treated patients showed substantial improvements from baseline to 6 months after initiation in real-world effectiveness measures (Table 1); results were similar between ADA and IFX regardless of baseline disease severity. No statistically significant differences were observed between two groups for time to remission (P=.11 for moderate UC; P=.42 for severe UC). No significant differences were noted regarding rates of healthcare use in ADA- and IFX-treated patients (Table 2).Table 1: Clinical outcomes at initiation of therapy and at the visit closest to 6 months follow-up by treatment and UC severityTable 2: UC-related healthcare resource utilization rates (per 6 months) by treatment and UC severityConclusion: Both ADA and IFX were similarly effective in treatment of moderate and severe UC in a real-world clinical setting.
Resolving chemical structures in scanning tunnelling microscopy (2009)

With the invention of scanning probe techniques, direct imaging of single atoms and molecules became possible. Today, scanning tunnelling microscopy (STM) routinely provides angstrom-scale image resolution. At the same time, however, STM images suffer from a serious drawback - the absence of chemical information. Here we demonstrate a modification of STM that resolves the chemical structure of molecular adsorbates. The key to the new STM mode is a combined force sensor and signal transducer that is formed within the tunnelling junction when a suitable gas condenses there. The method probes the repulsive branch of the surface adsorption potential and transforms the force signal into a current. Obtained images achieve the same resolution as state-of-the-art atomic force microscopy (AFM). In contrast to AFM, however, our (uncalibrated) force sensor is of nanoscale dimensions and therefore intrinsically insensitive to those long-range interactions that make atomic-resolution AFM so demanding.
Screening of microRNAs for a repressor of hepatitis B virus replication (2018)

Our findings contribute to the understanding of the roles of miRNAs underlying HBV replication and show the possibility of developing a novel strategy for miRNA-mediated HBV treatment.
Repair Is Nearly Generation: Multilingual Program Repair with LLMs (2022)

Most programmers make mistakes when writing code. Some of these mistakes are small and require few edits to the original program -- a class of errors recently termed last mile mistakes. These errors break the flow for experienced developers and can stump novice programmers. Existing automated repair techniques targeting this class of errors are language-specific and do not easily carry over to new languages. Transferring symbolic approaches requires substantial engineering and neural approaches require data and retraining. We introduce RING, a multilingual repair engine powered by a large language model trained on code (LLMC) such as Codex. Such a multilingual engine enables a flipped model for programming assistance, one where the programmer writes code and the AI assistance suggests fixes, compared to traditional code suggestion technology. Taking inspiration from the way programmers manually fix bugs, we show that a prompt-based strategy that conceptualizes repair as localization, transformation, and candidate ranking, can successfully repair programs in multiple languages with minimal effort. We present the first results for such a multilingual repair engine by evaluating on 6 different languages and comparing performance to language-specific repair engines. We show that RING can outperform language-specific repair engines for three of these languages.
Legs Pose Estimation using a Planar Mirror for a Rehabilitation Training System (2011)

This paper presents a motion capture based rehabilitation training system for a lower-limb paretic patient. The system evaluates the rehabilitation status of the patient by using the knees’ bend posture and the weight balance of the body. The posture of both legs is captured with a single camera using the planar mirror. The weight distribution is obtained by the Wii Balance Board. Self-occlusion problem in the tracking of the legs is resolved by using k-nearest-neighbor based clustering with both attributes of the body’s symmetry and local-linearity of the posture data. To do this, we present data normalization and its symmetric property in the normalized vector space.
Ultra-compact 4-sector antenna system based on modified Van Atta array (2013)

This paper presents the design and experimental characterization of an ultra compact four sector antenna system operating in the 5 GHz WiFi band. The design is based on the use of a modified Van Atta retro-directive array [1] where very closely spaced elements are placed in the near field of the feeding sources. More than 10 dBi directivity is obtained for each sector with a prototype realized on a multilayer PCB substrate. The antenna solution fits into a cylindrical volume of 30 mm of diameter × 13 mm high over a ground plane of 25 cm × 25 cm size and is well suited for integration in WiFi embedded home devices such as Set Top Boxes or Home Gateways.
Hospital-integrated Biobanking as a Service – The Interdisciplinary Bank of Biomaterials and Data Wuerzburg (ibdw) (2018)

The ibdw was established in 2011 as one of 5 centralised national biobanks in Germany within the framework of the governmental funding program “Nationale Biobank-Initiative”. The ibdw is a joint core facility of both, the University Hospital and the Julius-Maximilians-University Würzburg and acts as a faculty-wide service provider of human biological material for medical research. From the outset main emphasis was placed on comprehensive automation and seamless integration of sample collection in clinical routine workflows thereby securing highest quality standards. The ibdw collects fluid and tissue samples in parallel from patients, based on a broad informed consent, hence not limiting future research use.
High-resolution, anamorphic, adaptive small-animal SPECT imaging with silicon double-sided strip detectors (2011)

We are developing a prototype gamma-ray imaging system that consists of two sets of movable, keel-edged copper-tungsten blades configured as crossed slits. These apertures can be positioned independently between the object and detector, producing an anamorphic image in which the axial and transaxial magnifications are not constrained to be equal. The detector is a 60 mm × 60 mm, millimeter thick, one-megapixel silicon double-sided strip detector. The flexible nature of this system allows the application of adaptive imaging techniques. We will discuss system details, calibration and acquisition methods, and our progress towards biological imaging applications.
Fabrication of three dimensional split ring resonators by stress-driven assembly method (2012)

We demonstrate a self-assembly strategy for fabricating three dimensional (3D) metamaterials. This strategy represents the desired 3D curving prongs of the split ring resonators (SRRs) erected by metal stress force with appropriate thin film parameters. Transmittance spectra and field patterns corresponding to each resonance modes are calculated by finite element method (FEM). The eigen-modes of the SRRs can be excited by normal illumination with polarization state parallel to the erected SRRs, which are unlike for the cases of planar SRRs. This method opens a promising fabrication process for the application of tailored 3D SRRs.
ChemInform Abstract: Dihydrohymenialdisines, New Pyrrole‐2‐aminoimidazole Alkaloids from the Marine Sponge Cymbastela cantharella. (2011)

Abstract (+)‐Dihydrohymenialdisine (Ia), (‐)‐dihydrohymenialdisine (IIa) and their debromo analogues are identified as new products.
Compact Quad-Mode Planar Phased Array With Wideband for 5G Mobile Terminals (2018)

In this paper, a quad-mode endfire planar phased antenna array with wide scan angle and 1.2 mm clearance is proposed for 5G mobile terminals. The proposed antenna can obtain over 8 GHz of impedance bandwidth. In this paper, it is suggested to efficiently combine a multimode array element with different radiation patterns for each mode into a phased antenna array. In the array, similar and wide embedded radiation patterns are obtained for the all four modes. Furthermore, a coaxial to differential stripline transition is designed in this paper. The differential feeding structure is very compact and utilizes only MMPX connector and vias. The total scan pattern and coverage efficiency of the measured and simulated phased array antenna are calculated in the range from 25 to 33 GHz, and good agreement between measured and simulated results is observed. The mean coverage efficiency along the frequency range is very similar, but minor difference in variance of coverage efficiency is observed in the measurements. The coverage efficiency of around 50% for the threshold gain of 5 dBi is achieved in the chosen frequency range.
69‐4: Active Backplane Design for Digital Video Walls (2017)

We report on the design of a scalable active backplane for digitally driven video wall displays. The substrates use single‐crystal silicon spheres which are embedded in ceramic and planarized.
Obesity Is an Independent Risk Factor of Early Complications After Revision Spine Surgery (2015)

3.
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation (2018)

The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S mutation exhibited neurite collapse when challenged with the ER Ca<sup>2+</sup> influx sarco/ER Ca<sup>2+</sup>-ATPase inhibitor thapsigargin (THP). Baseline ER Ca<sup>2+</sup> levels measured with the ER Ca<sup>2+</sup> indicator CEPIA-ER were lower in LRRK2 G2019S human neurons, including in differentiated midbrain dopamine neurons in vitro. After THP challenge, PD patient-derived neurons displayed increased Ca<sup>2+</sup> influx and decreased intracellular Ca<sup>2+</sup> buffering upon membrane depolarization. These effects were reversed following LRRK2 mutation correction by antisense oligonucleotides and gene editing. Gene expression analysis in LRRK2 G2019S neurons identified modified levels of key store-operated Ca<sup>2+</sup> entry regulators, with no alterations in ER Ca<sup>2+</sup> efflux. These results demonstrate PD gene mutation LRRK2 G2019S ER calcium-dependent pathogenic effects in human neurons.
Immunoreactive and biologically active somatostatin in human and sheep milk (1985)

The presence of immunoreactive and biologically active somatostatin in sheep and human milk has been demonstrated. Milk somatostatin exhibits similar chromatographic behavior to that of synthetic somatostatin-14 on both reversed-phase C18 and cation-exchange high-performance liquid chromatography columns. Milk, in contrast to plasma, contains only somatostatin-14-like material. Milk somatostatin was capable of inhibiting the basal and the prostaglandin-induced release of growth hormone from anterior pituitary cell cultures in a pattern similar to synthetic somatostatin-14. The concentrations of the peptide, as determined by radioimmunoassay, were found to be 113 pg/ml in human milk and 150 +/- 4.8 pg/ml (mean +/- range) in sheep milk. These values are severalfold higher than the corresponding concentration of the peptide in the plasma of these species. These findings are analogous to our previous observations concerning two other hypothalamic hormones, luliberin and thyroliberin [Baram, T., Koch, Y., Hazum, E. and Fridkin, M. (1977) Science (Wash. DC) 198, 300-302]. The high concentration of somatostatin and other neuropeptides in milk implies either an active concentrating mechanism in the mammary gland or an additional extrahypothalamic source for the synthesis and release of these peptides.
OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer (2011)

Despite many advances in oncology, almost all patients with pancreatic cancer (PC) die of the disease. Molecularly targeted agents are offering hope for their potential role in helping translate the improved activity of combination chemotherapy into improved survival. Heat shock protein 27 (Hsp27) is a chaperone implicated in several pathological processes such as cancer. Further, Hsp27 expression becomes highly upregulated in cancer cells after chemotherapy. Recently, a modified antisense oligonucleotide that is complementary to Hsp27 (OGX-427) has been developed, which inhibits Hsp27 expression and enhances drug efficacy in cancer xenograft models. Phase II clinical trials using OGX-427 in different cancers like breast, ovarian, bladder, prostate and lung are in progress in the United States and Canada. In this study, we demonstrate using TMA of 181 patients that Hsp27 expression and phosphorylation levels increase in moderately differentiated tumors to become uniformly highly expressed in metastatic samples. Using MiaPaCa-2 cells grown both in vitro and xenografted in mice, we demonstrate that OGX-427 inhibits proliferation, induces apoptosis and also enhances gemcitabine chemosensitivity via a mechanism involving the eukaryotic translation initiation factor 4E. Collectively, these findings suggest that the combination of Hsp27 knockdown with OGX-427 and chemotherapeutic agents such as gemcitabine can be a novel strategy to inhibit the progression of pancreas cancer.
Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux (2008)

The ASP microarray has potential in the clinic as a diagnostic tool, as a research tool for both known and emerging pathogens, and as an early warning system for pathogenic bacteria that have been recently modified either naturally or deliberately.
<title>Human vision and image rendering: is the story over, or is it just beginning?</title> (1998)

Human vision plays an essential role, either implicity or explicitly in image rendering, especially digital halftoning. In this paper, we review the progress that has been made in the past 16 years in understanding the visual characteristics of halftone texture and in the use of human visual system models as an intrinsic part of the halftoning algorithm. We examine the development of the direct binary search halftoning algorithm as a case study in the challenges of achieving satisfactory computational performance with a model-based halftoning algorithm.
Investigations into the Chemistry of Thermodynamically Unstable Species. The Direct Polymerization of Vinyl Alcohol, the Enolic Tautomer of Acetaldehyde (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations into the Chemistry of Thermodynamically Unstable Species. The Direct Polymerization of Vinyl Alcohol, the Enolic Tautomer of AcetaldehydeAnna K. Cederstav and Bruce M. NovakCite this: J. Am. Chem. Soc. 1994, 116, 9, 4073–4074Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ja00088a051https://doi.org/10.1021/ja00088a051research-articleACS PublicationsRequest reuse permissionsArticle Views793Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A lanthanide-based helicate coordination polymer derived from a rigid monodentate organic bridge synthesized in the solid state (2008)

Tetratopic rctt-tetrakis(4-pyridyl)cyclobutane acts as an angular bifunctional ligand that yields a single-stranded helicate coordination polymer based on a Ln(III) ion.
Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas (1997)

The proliferative capacity of T cells infiltrating human tumors is known to be impaired, possibly through their interaction with tumor. Here we demonstrate that soluble products derived from renal cell carcinoma (RCC-S) explants but not normal kidney can inhibit an IL-2-dependent signaling pathway that is critical to T cell proliferation. A major target of the immunosuppression was the IL-2R-associated protein tyrosine kinase, Janus kinase 3 (Jak3). RCC-S suppressed basal expression of Jak3 and its increase following stimulation with anti-CD3/IL-2. Jak3 was most sensitive to suppression by RCC-S; however, reduction in expression of p56(lck), p59(fyn), and ZAP-70 was observed in some experiments. Expression of other signaling elements linked to the IL-2R (Jak1) and the TCR (TCR-zeta, CD3-epsilon, and phospholipase C-gamma) were minimally affected. In naive T cells, RCC-S also partially blocked induction of IL-2R alpha-, beta- and gamma-chain expression when stimulating via the TCR/CD3 complex with anti-CD3 Ab. To determine whether RCC-S suppressed IL-2-dependent signaling, primed T cells were employed since RCC-S had no effect on IL-2R expression but did down-regulate Jak3 expression and, to a lesser degree, p56(lck) and p59(fyn). Reduction in Jak3 correlated with impaired IL-2-dependent proliferation and signal transduction. This included loss of Jak1 kinase tyrosine phosphorylation and no induction of the proto-oncogene, c-Myc. These findings suggest that soluble products from tumors may suppress T cell proliferation through a mechanism that involves down-regulation of Jak3 expression and inhibition of IL-2-dependent signaling pathways.
Using a priori knowledge to classify in vivo images of the lung (2010)

International audience
Pharmacokinetics and excretion of dalbavancin in the rat (2005)

Dalbavancin has a long t(1/2) (approximately 8 days) in the rat and distributes widely throughout the body. It is not selectively retained in any single organ, tissue or blood component and is completely eliminated by both renal and non-renal routes in rats. These data were useful in designing and interpreting animal infection model studies used to select the dose for human studies.
Biselides A and B, Novel Macrolides from the Okinawan Ascidian Didemnidae sp. (2004)

Abstract Two new macrolides, biselides A (1) and B (2), were isolated from the Okinawan ascidian Didemnidae sp. Their structures were determined by spectroscopic analysis.
A2A adenosine receptor mediates suppression in a mouse model of colitis (39.1) (2009)

Abstract Background: Adenosine accumulates in inflamed tissue and can suppress proliferation and cytokine production in helper T cells (Th). Th cells from mice lacking the A2A Adenosine Receptor (A2AAR-/-) do not function properly in the CD45RB transfer model of colitis. Methods: To examine the role of A2AAR in regulating colitis, we tested colonic myeloperoxidase (MPO) activity after adoptive transfer of Th cell susbsets from wildtype or A2AAR-/- mice. Th cells from mesenteric lymph nodes (MLN) of colitic mice were treated with an A2AAR agonist to assess effects on cytokine production. To investigate the role of A2AAR on myeloid cells in the CD45RB model of colitis, we adoptively transferred wildtype Th cells into RAG1/A2AAR double knockout (DKO) mice. Results: Colons of mice that received A2AAR-/- CD45RBhi cells with wildtype or A2AAR-/- CD45RBlo Treg had significantly greater MPO activity than mice that received wildtype CD45RBhi and CD45RBlo cells. Cytokine production by MLN Th cells from colitic mice was suppressed by an A2AAR agonist. Adoptive transfer of CD45RBhi Th cells into either RAG1-/- or DKO mice induced colitis but co-transfer of CD45RBlo Tregs attenuated colitis only in RAG1-/- mice. Conclusions: These data indicate that adenosine signaling through A2AAR plays an important suppressive role in colitis and that this is mediated through effects on both T cells and myeloid cells. CK supported by a CCFA Fellowship.
F-44 Aerosol Filter Analysis Using Scanning Micro X-ray Fluorescence (2007)

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Self-bending of a spatially asymmetric CO2 laser beam in CS2 (1988)

An intense transversely symmetric laser beam impinging on a prism with a nonlinear material exhibits intensity-dependent deflection.1 Conversely, a light with spatially nonuniform intensity distribution over its cross section is subject to self-bending while propagating through a nonlinear media.2 The self-bending is in the direction in which the refraction is maximal, i.e., in the direction of maximal intensity in the media with a positive nonlinear refractive index n2.