gebhart/patrepeval huggingface dataset:
Boron-Doped Peroxo-Zirconium Oxide Dielectric for High-Performance, Low-Temperature, Solution-Processed Indium Oxide Thin-Film Transistor (2013)

We developed a solution-processed indium oxide (In2O3) thin-film transistor (TFT) with a boron-doped peroxo-zirconium (ZrO2:B) dielectric on silicon as well as polyimide substrate at 200 °C, using water as the solvent for the In2O3 precursor. The formation of In2O3 and ZrO2:B films were intensively studied by thermogravimetric differential thermal analysis (TG-DTA), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FT IR), high-resolution X-ray diffraction (HR-XRD), and X-ray photoelectron spectroscopy (XPS). Boron was selected as a dopant to make a denser ZrO2 film. The ZrO2:B film effectively blocked the leakage current at 200 °C with high breakdown strength. To evaluate the ZrO2:B film as a gate dielectric, we fabricated In2O3 TFTs on the ZrO2:B dielectrics with silicon substrates and annealed the resulting samples at 200 and 250 °C. The resulting mobilities were 1.25 and 39.3 cm(2)/(V s), respectively. Finally, we realized a flexible In2O3 TFT with the ZrO2:B dielectric on a polyimide substrate at 200 °C, and it successfully operated a switching device with a mobility of 4.01 cm(2)/(V s). Our results suggest that aqueous solution-processed In2O3 TFTs on ZrO2:B dielectrics could potentially be used for low-cost, low-temperature, and high-performance flexible devices.
Mechanism of substrate dephosphorylation in lowMr protein tyrosine phosphatase (1999)

Substrate dephosphorylation by the low molecular weight protein tyrosine phosphatases proceeds via nucleophilic substitution at the phosphorous atom yielding a cysteinyl phosphate intermediate. However, several questions regarding the exact reaction mechanism remain unanswered. Starting from the crystal structure of the enzyme we study the energetics of this reaction, using the empirical valence bond method in combination with molecular dynamics and free energy perturbation simulations. The free energy profiles of two mechanisms corresponding to different protonation states of the reacting groups are examined along stepwise and concerted pathways. The activation barriers calculated relative to the enzyme-substrate complex are very similar for both monoanionic and dianionic substrates, but taking the substrate binding step into account shows that hydrolysis of monoanionic substrates is strongly favored by the enzyme, because a dianionic substrate will not bind when the reacting cysteine is ionized. The calculated activation barrier for dephosphorylation of monoanionic phenyl phosphate according to this novel mechanism is 14 kcal mol(-1), which is in good agreement with experimental data. Proteins 1999;36:370-379.
77 and 94-GHz Downconversion Mixers in SiGe BiCMOS (2006)

Double-conversion superheterodyne downconverter blocks operating around 77 GHz and 94 GHz have been realized in 0.13-mum SiGe BiCMOS technology. Both use a single-balanced RF mixer to downconvert the signal to an 8.8 GHz IF, which is amplified and downconverted a second time to baseband. The 77-GHz circuit achieves an upper SSB NF of 12.8 dB at 77 GHz and <12 dB at 76 GHz, with 20 dB of conversion gain and an input-referred 1-dB compression point of -14.7 dBm. The 94-GHz circuit achieves an upper SSB NF of 17.2 dB at 94 GHz, with 15 dB of conversion gain and an input-referred 1-dB compression point of -10.7 dBm. Both circuits use a bias current of 3.2 mA in the RF mixer core, with total testsite power consumption of 120 mA from a 3-V supply.
Monoclonal Antibodies: A Prospective and Retrospective View (2020)

The topics here discussed prove the undisputed role of mAbs as innovative biopharmaceuticals molecules and as vital components of targeted pharmacological therapies.
[Studies about the dose distribution in the marginal field regions (author's transl)]. (1980)

The authors have examined in an experimental study what influence is exerted by the width of the boundary line between two adjacent fields and by the dose inhomogeneity on the suture points lying in the region of the target volume. The results of this study are presented and the influence exerted on the dose distribution by different diaphragm sizes is shown by means of longitudinal and cross sections. The conclusion for the practical application of radiotherapy is that there exists a possibility to obtain homogenous dose distributions also beyond the borders of the field.
Abstract 3856: MTLCEBPA, a drug candidate for hepatocellular-carcinoma enhances efficacy of Sorafenib (2019)

Abstract MTLCEBPA, a non-toxic therapeutic oligonucleotide formulated inside SMARTICLES (liposomal nanoparticles) is currently under a Phase I study for patients with advanced hepatocellular carcinoma (HCC). We have demonstrated in multiple in vivo liver disease models that MTLCEBPA can improve liver function and inhibit HCC tumor growth. Here we show that upregulation of hepatic CEBPA expression by MTLCEBPA enhances the effects of Sorafenib in a (Diethylnitrosamine) DEN induced cirrhotic HCC rat model by significantly reducing liver tumor volume after only two weeks of combination treatment when compared to untreated control or single agent treatment only. In this study, we established cirrhosis and HCC by exposing male Wistar rats to DEN for 6 weeks. Animals were randomized into 5 groups comprising of: 1. PBS control; 2. MTL-CEBPA treatment (TIW at 3mg/kg) for one week; 3. MTL-CEBPA treatment (TIW at 3mg/kg) for two weeks; 4. Sorafenib TIW at 10mg/kg for two weeks; and 5. MTLCEBPA at 3mg/kg at week one combined with Sorafenib 10mg/kg at week 2 group. The results here indicate that Sorafenib combined with MTLCEBPA significantly inhibits tumor growth when compared to single agent treatment. Tumor sizes averaged at 644.7mm3 (± 88.57) in group 1 compared to 326mm3 (± 53.05) in group 2; 199.7mm3 (± 54.73) in group 3 and 299.5mm3 (± 77.1) in group 4. In combination treatment (group 5) the tumor sizes averaged at 101.3mm3 (± 37.48). Serum AFP change (posttreatment values - pre-treatment) was more prominent in the MTLCEBPA/Sorafenib combination treatment (group 5) where there was a 4-fold reduction in values after treatment when compared to control groups 1-4. Serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and total bilirubin remained unchanged across all the treatment groups suggesting no deterioration in liver function during the study period. These results suggest that MTLCEBPA improved the efficacy of Sorafenib in this DEN induced HCC model, indicating a promising therapeutic option for advanced HCC patients who can no longer be treated with potentially more effective local therapies. Citation Format: Nagy A. Habib, Kai-Wen Huang, Vikash Reebye, Mikael Sodergren, John Rossi. MTLCEBPA, a drug candidate for hepatocellular-carcinoma enhances efficacy of Sorafenib [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3856.
Modeling the Effect of Asphaltene on the Development of the Marrat Field (2009)

Abstract This paper describes the study of the effect of asphaltene precipitation and deposition on the development of the Marrat field using a compositional simulation model with asphaltene modeling facilities. The model enables the simulation of asphaltene precipitation, flocculation, and deposition including adsorption, plugging, and entrainment, and the resulting reduction in porosity and permeability and changes in oil viscosity and rock wettability. A workflow was established in the study to i) characterize the equation of state (EOS) by analyzing the fluid PVT and asphaltene data from the lab; ii) calibrate the asphaltene model input parameters using the core flood experimental data; and iii) incorporate the EOS and the asphaltene parameters into the full field simulation model. The model was used to analyze the effects of asphaltene on various development scenarios, including depletion and water injection. For each scenario, the following were calculated and analyzed: field performance including production of oil, gas, and water; asphaltene behavior including precipitation, flocculation, adsorption, plugging and entrainment; formation damage and the effect of rock wettablity changes. The results show that the formation could be severely damaged near the producers where asphaltene is more likely to precipitate because of lower pressures (below the asphaltene onset pressure) and longer time exposure to a larger amount of oil. Formation damage could be reduced by flushing away the deposited asphaltene using higher flow rates if plugging is not significant. The water injection scenario with higher injection rate and higher production rate with BHP limit above 6,000 psia results in less asphaltene adsorption, more entrainment, and therefore less deposition. This in turn causes less permeability damage and more oil production.
Deletion of sequences telomeric of the EVI1 gene in 3q26 associated with a novel pericentric inv(3)(p25q26) in a patient with acute myelogenous leukemia. (2003)

In this report, we describe a novel acquired chromosome rearrangement affecting the EVI1 locus in band 3q26 in a patient with myeloid leukemia. The pericentric inversion, inv(3)(p25q26), was associated with a 750kb deletion, and led to EVI1 overexpression. Similar deletions were not found in five primary leukemia samples with the recurrent EVI1-rearrangements inv(3)(q21q26) and t(3;3)(q21;q26).
Quantization and Noise-Shaped Coding for High Efficiency Transmitter Architectures (2009)

Three driving parameters in the development of transmitter technologies for wireless communication today is: energy efficiency, flexibility and footprint reduction. This thesis investigates the use of 1-bit oversampled signal representation, mainly as a power efficiency enhancement technique for the transmitter, but also as a path toward reduced footprint and increased flexibility. Common transmitter architectures comprising this representation of the signal on either baseband or RF level are discussed and analyzed. Two common methods of mapping a complex baseband signal to different characteristics of a pulse-train, Pulse Width Modulation and Pulse Density Modulation are discussed. Noise-Shaped Coding, an inherent feature of Pulse Density Modulation, is illustrated and discussed. The implementation of Pulse Density Modulation and the determination of the Noise-Shaped Coding properties are explored within a class of oversampled A/D-converters commonly referred to as the ΣΔ-modulators. A few different approaches of analyzing the ΣΔ-modulator is discussed and a novel ΣΔ-modulator representation is introduced. Further on, an algorithm designed to achieve arbitrary Noise Shaped Coding by optimized selection of the loop-filter coefficients in the ΣΔ-structure is developed. This algorithm uses a Monte Carlo-based technique in combination with a differentiable approximation of the quantizer element and a damped Gauss-Newton search.Finally, a novel method for quantization noise suppression close to the RF-carrier is proposed. The method is based on the superposition of a selective amplitude variation onto the quantized signal. Simulations are performed on an equivalent baseband model comprising a generalized memory polynomial model for linearization. The method is then successfully demonstrated with measurements in a carrier bursting transmitter working on a high efficiency, 10 W Si-LDMOS power amplifier.
Development of a Highly Sensitive Neurofilament Light Chain Assay on an Automated Immunoassay Platform (2022)

The analytical performance of the NfL assay fulfilled all acceptance criteria; therefore, we suggest that the assay is acceptable for use in both research and clinical practice settings to determine elevated NfL levels in patients.
Synthesis of new Enrofloxacin Derivatives as Potential Antibiofilm Drugs Against Staphylococcus Aureus and Klebsiella Pneumoniae (2020)

These compounds can be used alone or with FDA approved drugs to overcome biofilm related K. pneumoniae and S. aureus infections.
The SpectrumWare testbed for ATM-based software radios (2002)

This paper describes the SpectrumWare testbed and two experimental systems we are developing: an ATM-based wideband receiver and the receive side of a GSM base station. These projects leverage recent advances in processor and analog-to-digital conversion technology that have enabled a software-oriented approach to wireless communication and distributed sample processing.
Expedient Synthesis of Cyclopropane α‐Amino Acids by the Catalytic Asymmetric Cyclopropanation of Alkenes Using Iodonium Ylides Derived from Methyl Nitroacetate. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct evidence of dislocation transmission through ∊= 9 grain boundaries in germanium and silicon byin situhigh-voltage electron microscopy observations (1990)

Abstract In situ straining experiments of Si and Ge bicrystals in the high-voltage electron microscope have clearly revealed that dislocations can be transmitted across ∊ = 9 coincidence tilt boundaries even when their Burgers vector is not a lattice vector of the second grain. Observed transmitted dislocations are either perfect dislocations with ½‘110’ Burgers vector or, more often, Shockley partial dislocations trailing behind them extended stacking faults linked to the grain boundary. Dissociation of dislocations into DSC dislocations glissile in the boundary was also observed. Observations of repeated transmission events at a given area of the grain boundary suggest that residual dislocations can be removed from the impact point. The main-but not all-observed features are explained by a simple model based on energy calculations of the possible dislocation configurations formed at successive steps of the transmission process.
USE OF NATURAL LANGUAGE PROCESSING TOOLS TO IDENTIFY AND CLASSIFY PERIPROSTHETIC FEMORAL FRACTURES FROM ELECTRONIC HEALTH RECORDS (2018)

Introduction Manual chart review is labor-intensive and requires specialized knowledge possessed by highly-trained medical professionals. The cost and infrastructure challenges required to implemen...
ChemInform Abstract: Treatment of N,N‐Dibenzylamino Alcohols with Sulfonyl Chloride Leads to Rearranged β‐Chloro Amines, Precursors to β‐Amino Acids, and Not to Tetrahydroisoquinolines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mythes et réalités de l'érémitisme au XVIIIe siècle: les ermites des Pays-Bas autrichiens et leur suppression par Joseph II en 1783 (1989)

info:eu-repo/semantics/published
Book reviewsThe physical principles of computed tomography. By HendeeW. R., pp. xii + 192, 1983 (Little, Brown, Boston; Quest, Beckenham, Kent), $35.75. ISBN 0–316–35594–1 (1984)

After a brief historical introduction to computed tomography, the chapters of this book deal with equipment, the image and its information content, and a collection of CT applications that include other imaging modalities. The author states that the book is intended to be read by physicians, physicists, engineers and technologists who have an interest in, or work with, CT. With such a wide proposed readership the text naturally loses some coherence and consistency in the depth to which material is treated, with the result that it gives too little information in certain areas or intricate detail in others.
Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human (2022)

Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 13-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical pulses with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Our results highlight the utility of eiDBS to characterize the role of oscillatory dynamics in PD and other brain conditions, and to develop personalized neuromodulation systems.
Phase matching, quasi phase matching and pulse compression in a single waveguide for enhancing high harmonic generation (2005)

We demonstrate enhancement of high harmonic generation in the technologically significant 95 eV photon energy region by combining phase matching, quasi phase matching, and pulse compression in a single gas-filled waveguide. The waveguide geometry allows us to use argon gas as the generating medium, which also leads to enhanced emission due to its higher nonlinearity. The induced shock front due to laser pulse compression in the ionizing gas medium also generates an X-ray continuum at low pressure, with a spectrum corresponding to an isolated, 50 attosecond, X-ray pulse.
Lifetime measurements of the e 1 II, v = 0 and v = 1 states of 12 C 16 O, 13 C 16 O, and 13 C 18 O (1998)

In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E 1u, v = 0 and v = 1 states of CO are experimentally determined. For E 'D, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.6% result for 12C16O, 13C16O, and 13C18O in the case of the E 1u, v = I state, which is the state that predominantly influences the isotopic fractionation of CO in interstellar clouds.
An E-band 40dB dynamic range multi-tanh power detector in 0.13&#x03BC;m SiGe technology (2014)

This paper describes circuit design and measurement results of a multi-tanh bipolar rms power detector (PD) for applications in E band (65-86 GHz) frequency range. The PD is designed and fabricated in IBM 0.13um SiGe technology. In the matched frequency range, the measured input dynamic range is over 40 dB, withstanding an input power of 17dBm, with an overall sensitivity of 27.5 mV/dB. The output voltage response is nearly frequency-independent, varying by less than 1.5 dB for a given input RF power, as the RF frequency is swept across the operating frequency range. Static power consumption is 12mW from a 2.7V supply.
The conductivity behavior of multi‐component epoxy, metal particle, carbon black, carbon fibril composites (2002)

Abstract Following the previous studies of epoxy/silver conductive composites, a detailed investigation of the influence of ethylene glycol on the resulting resistivity of various composites was carried out. Ethylene glycol was found to have a catalytic effect on the curing process of the epoxy resin, verified by differential scanning calorimetry studies. The accelerated curing process diminishes settling of the metal particles and therefore results in better and more uniform conductivities. High temperature curing of the composites was found to have a similar effect on the conductivity. The conductivity behavior of some other composites, such as epoxy/nickel, epoxy/nickel/carbon fibrils, and epoxy/carbon black/carbon fibrils, were also studied. The structure–property relations were better understood through scanning electron microscopy observations. Silver and nickel particles were found to perform differently in the cured epoxy, showing different percolation concentrations and conductivity levels. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 1706–1713, 2002
Low level of HIV-1 evolution after transmission from mother to child (2014)

Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure.
Supercontinuum generation in a fiber grating (2004)

We show that supercontinuum generation in a fiber containing a Bragg grating exhibits &amp;gt;10× enhancement near the Bragg resonance wavelength. We also show that the grating dispersion exceeds the waveguide dispersion over a bandwidth far in excess of its photonic band gap. The observed enhancement is consistent with nonlinear Schrödinger equation simulations of the supercontinuum formation that combine grating and waveguide dispersion.
Hydroxylation of alkanes using H2O2 or tert-BuOOH catalyzed by silica-based Fe(III) interphase catalysts (2006)

Two novel silica-based organic-inorganic hybrid(interphase) Fe(III) catalysts have been successfully prepared by the flexible ligand method, characterized and applied to the efficient catalytic oxidation of various types of substrates using 30% H 2 O 2 or tert-BuOOH under mild conditions. The catalysts can be recovered and reused for four reaction cycles with total turnover numbers being about 29 using cyclohexene as the substrate. The mechanism for the O-O bond cleavage was proposed based on the results in combination with previous experimental results.
Optimal-trade-off filters for noise robustness, peak sharpness, and light efficiency in nonoverlapping background noise (2000)

A design of filters for pattern recognition is presented that have optimal trade-off for the criteria of noise robustness, peak sharp- ness, and Horner efficiency, when input scene noise is spatially disjoint (nonoverlapping) with the target. Three different criteria—signal-to-noise ratio, peak-to-output energy ratio, and light efficiency—are used to de- sign the filter. Computer simulations for the various types of noise and parameters illustrate the performance of such filters for optical pattern recognition. © 2000 Society of Photo-Optical Instrumentation Engineers. (S0091-3286(00)03002-6) Subject terms: matched filtering; optical pattern recognition; multicriteria optimi- zation.