gebhart/patrepeval huggingface dataset:
Electron donor-acceptor complexes as potential high-efficiency second-order nonlinear optical materials. A computational investigation (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron donor-acceptor complexes as potential high-efficiency second-order nonlinear optical materials. A computational investigationSanto Di Bella, Ignazio L. Fragala, Mark A. Ratner, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1993, 115, 2, 682–686Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ja00055a043https://doi.org/10.1021/ja00055a043research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibition of plasmin by fibrinogen (1990)

The kinetics of inhibition of the amidolytic activity of plasmin on D-Val-L-Leu-L-Lys p-nitroanilide hydrochloride (S-2251) by fibrinogen and fibrin were determined. Reciprocal (1/v versus 1/[S]) plots of plasmin inhibition by 0.50 microM-fibrinogen showed a non-linear downward curve. The Hill coefficient (h) was 0.68, suggesting negative co-operativity. By contrast, fibrin produced a simple competitive inhibition of plasmin (Ki = 12 micrograms/ml). Addition of 0.1 mM-6-aminohexanoic acid shifted the non-linear curve obtained in the presence of fibrinogen to a straight line as for controls, indicating that 6-aminohexanoic acid abolishes the fibrinogen-induced inhibition. Transient exposure of the enzyme to pH 1.0 abrogates the ability of fibrinogen to inhibit plasmin activity. Acidification had no effect on the Vmax but increased the Km of plasmin. The present evidence for modulation of plasmin reveals a novel mechanism for control of fibrinolysis by fibrinogen, a component of the coagulation system and the precursor of the physiological substrate of plasmin.
Control Plane Design and Implementation for a Media Streaming System working in Over the Top style (2016)

Content/media streaming services are frequently used in the current Internet and this trend is estimated to continue in the next years. Complex architectures, like Content Delivery Networks, have been developed and are currently exploited on a large scale, or novel architectures like Content Oriented Networks are proposed. In parallel, cheaper and light architecture, working in over-the-top (OTT) style above the current IP networks multi-domain infrastructures have been recently considered, as an attractive solution for media distribution. A content streaming OTT-like system is considered here, working on top of a multi-domain IP network. The system integrates functionalities such as content server initial selection based on multi-criteria algorithm and then performs dynamic media adaptation and/or server switching - during the media session. This paper continues and extends a preliminary work; it presents more deeply the main design concepts, then develops the implementation solutions and presents the functional conformance testing for the Control Plane of the above system. The functional testing is described, performed on a real-life multi-domain testbed as a part of the overall validation campaign.
Polarization self-screening in [0001] oriented InGaN/GaN light-emitting diodes for improving the electron injection efficiency (2014)

InGaN/GaN light-emitting diodes (LEDs) grown along the [0001] orientation inherit very strong polarization induced electric fields. This results in a reduced effective conduction band barrier height for the p-type AlGaN electron blocking layer (EBL) and makes the electron blocking effect relatively ineffective and the electron injection efficiency drops. Here, we show the concept of polarization self-screening for improving the electron injection efficiency. In this work, the proposed polarization self-screening effect was studied and proven through growing a p-type EBL with AlN composition partially graded along the [0001] orientation, which induces the bulk polarization charges. These bulk polarization charges are utilized to effectively self-screen the positive polarization induced interface charges located at the interface between the EBL and the last quantum barrier when designed properly. Using this approach, the electron leakage is suppressed and the LED performance is enhanced significantly.
Thermal desorption and pyrolysis direct analysis in real time mass spectrometry for qualitative characterization of polymers and polymer additives (2019)

In comparison with direct analysis by positioning sample directly in the heated DART gas stream, TDPy DART provides a more versatile sampling method and provides thermal separation and profiling of polymer additives, intact short polymer chains, and pyrolysis fragments.
Dual-level inorganic write-once Blu-ray Disc (2003)

We worked on an inorganic write-once technology based on hole formation and developed a possible stack for a dual level blu-ray disc with amorphous tellurium alloys. The study was tackled from different point of view: material, optical and thermal aspects.
Simulating Autonomous Telecommunication Networks for Space Exploration (2008)

Currently, most interplanetary telecommunication systems require human intervention for command and control. However, considering the range from near Earth to deep space missions, combined with the increase in the number of nodes and advancements in processing capabilities, the benefits from communication autonomy will be immense. Likewise, greater mission science autonomy brings the need for unscheduled, unpredictable communication and network routing. While the terrestrial Internet protocols are highly developed their suitability for space exploration has been questioned. JPL has developed the Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE) tool to help characterize network designs and protocols. The results will allow future mission planners to better understand the trade offs of communication protocols. This paper discusses various issues with interplanetary network and simulation results of interplanetary networking protocols.
Polyhomologation based on in situ generated boron-thexyl-silaboracyclic initiating sites: a novel strategy towards the synthesis of polyethylene-based complex architectures (2015)

A novel strategy, based on the in situ generated boron-thexyl-silaboracyclic initiating sites for the polyhomologation of dimethylsulfoxonium methylide, has been developed for the synthesis of complex polyethylene-based architectures. As examples, the synthesis of a 4-arm polyethylene star, three (polystyrene)(polyethylene)2 3-miktoarm stars and a PE-branched double graft copolymer is given.
Co3O4/Nitrogen-Doped Graphitic Carbon/Fe3O4 Nanocomposites as Reusable Catalysts for Hydrogenation of Quinoline, Cinnamaldehyde, and Nitroarenes (2021)

Developing efficient, robust, and highly recyclable catalysts with the ability to separate products conveniently for industrially important hydrogenation reactions is a major challenge. Edges of nanoparticles possessing selective catalytic properties while the completely exposed metal particles are devoid of this attribute is a known fact. Herein, the preparation and evaluation of a Co3O4/N-Gr/Fe3O4 magnetic heterostructure composed of Co3O4 nanoparticles surrounded by nitrogen-doped graphitic carbon derived from ZIF-67 on an Fe3O4 support is described. Wrapping Co3O4 nanoparticles with porous nitrogen-rich graphitic carbon increases their catalytic selectivity and durability. Co3O4/N-Gr/Fe3O4 is obtained by pyrolysis of metal–organic frameworks, ZIF-67(Co) with magnetic Fe3O4 nanoparticles under nitrogen. Scanning electron microscopy reveals Fe3O4 as uniform octagonal microcrystals (∼450 nm) and transmission electron microscopy (TEM) shows graphitic carbon layers around the core Co3O4 nanoparticles on Fe3O4 microcrystals. TEM using a high-angle annular dark-field with spherical aberration (Cs) correction shows the core–shell structure of Co3O4/N-Gr nanocrystals (∼20 nm) with the graphitic carbon layers surrounding the core Co3O4 nanoparticles on Fe3O4 microcrystals. The resulting Co3O4/N-Gr/Fe3O4 construct produces a stable and reusable catalyst for the selective hydrogenation of structurally diverse N-heteroarenes. Particularly, quinoline was quantitatively hydrogenated to 1,2,3,4-tetrahydroquinoline (py-THQ) at 120 °C under 40 bar of H2. The wide applicability of Co3O4/N-Gr/Fe3O4 was tested for selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde (HCAL) with >99% selectivity. Also, the tolerance of functional groups in the reduction of nitroarene was evaluated. The benefit of the ability to produce py-THQ was demonstrated by extending the protocol for the synthesis of bioactive molecules, that is, a tubulin polymerization inhibitor with a 94% yield. The robust nature of the Co3O4/N-Gr/Fe3O4 construct was demonstrated through multiple cycles of simple separation and reuse.
Editorial comment (2002)

No AccessJournal of Urology1 Feb 2002Editorial comment Allan J. Pantuck, Amnon Zisman, and Arie Belldegrun Allan J. PantuckAllan J. Pantuck More articles by this author , Amnon ZismanAmnon Zisman More articles by this author , and Arie BelldegrunArie Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(02)80287-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial comment." The Journal of Urology, 167(2 Part 2), pp. 876–877 References 1. : Value of thoracoabdominal incision in removal of kidney tumors. N Engl J Med1949; 241: 951. Google Scholar 2. : Radical nephrectomy for renal cell carcinoma. J Urol1963; 89: 37. Link, Google Scholar 3. Grayhack, J.: The kidney: tumors. In: The Year Book of Urology (1963-1964 year book series), p. 91, 1964 Google Scholar 4. : Renal cell carcinoma. Natural history and results of treatment. Cancer1970; 25: 26. Google Scholar 5. : Diagnosis and management of renal cell carcinoma. A clinical and pathological study of 309 cases. Cancer1971; 28: 1165. Google Scholar 6. : Prospective analysis of the incidence of ipsilateral adrenal metastasis in localized renal cell carcinoma. J Urol1996; 155: 1844. Link, Google Scholar 7. : Is adrenalectomy a necessary component of radical nephrectomy? UCLA experience with 511 radical nephrectomies. J Urol2000; 163: 437. Link, Google Scholar 8. : Incidental renal tumors. Urology2000; 56: 190. Google Scholar 9. : Conservative surgery of renal cell tumors in 140 patients: 21 years of experience. J Urol1992; 148: 24. Link, Google Scholar 10. : Nephron-sparing surgery for renal cell carcinoma. J Urol1993; 149. Google Scholar 11. : Surgical management of renal tumors 4 cm. or less in a contemporary cohort. J. Urol2000; 163: 730. Link, Google Scholar 12. : Malignant neoplasms of the kidney: analysis of 353 patients followed 5 years, or more. J Urol1958; 79: 196. Link, Google Scholar © 2002 by American Urological Association, IncFiguresReferencesRelatedDetailsCited byJewett M (2016) Outcomes after Radical Nephrectomy for Renal Cell CarcinomaJournal of Urology, VOL. 197, NO. 2S, (S114-S115), Online publication date: 1-Feb-2017.PATARD J, SHVARTS O, LAM J, PANTUCK A, KIM H, FICARRA V, CINDOLO L, HAN K, DE LA TAILLE A, TOSTAIN J, ARTIBANI W, ABBOU C, LOBEL B, CHOPIN D, FIGLIN R, MULDERS P and BELLDEGRUN A (2018) SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCEJournal of Urology, VOL. 171, NO. 6 Part 1, (2181-2185), Online publication date: 1-Jun-2004. Volume 167Issue 2 Part 2February 2002Page: 876-877 Advertisement Copyright & Permissions© 2002 by American Urological Association, IncMetricsAuthor Information Allan J. Pantuck More articles by this author Amnon Zisman More articles by this author Arie Belldegrun More articles by this author Expand All Advertisement PDF downloadLoading ...
Finite Width Currents, Non-Uniform Magnetic Shear and the Current Driven Ion Cyclotron Instability. (1983)

Our earlier results that non-local effects due to even a small magnetic shear produce a significant reduction of the growth rate of the ion cyclotron instability driven by a uniform current are now generalized to finite width currents. Externally prescribed as well as self-consistent shears are considered. If the current width Lc exceeds the shear length Ls, the previous results are recovered. Shear becomes less effective with reduction of Lc, and for typical parameters, the growth rate attains its (shearless) local value for Lc/Ls approximately less than 10 to the minus 2. Non-local effects of the finite current width itself come into play if Lc is further reduced to a few ion Larmor radii and can quench the instability.
GxG-Viztool: A program for visualizing gene-gene interactions in genetic association analysis (2012)

Gene-gene interactions are important factors underlying a common complex trait that is mostly polygenic. While many methods have been proposed to analyze gene-gene interactions in genetic association studies, the interpretation of the identified gene-gene interactions is not straightforward. In order to aid the interpretation of gene-gene interactions, we developed the GxG-Viztool, an executable program for visualizing gene-gene interactions in genetic association analysis. The GxG-Viztool provides an effective way to recognize genotype combinations that enhance/repress a trait and to display polygenic structure of interactions. The GxG-Viztool implements six graphical tools: checkerboard, pairwise checkerboard, forest, funnel, 3D lattice and parallel coordinate plots, which make it effective to recognize certain patterns in gene-gene interactions. It is freely available at http ://bibs. snu. ac. kr/GxG-Viz tool.
Mode-locked erbium-doped fibre ring laser using nonlinear polarization rotation (1998)

Abstract We present a theoretical study of a fibre ring laser in which mode locking is achieved by the combined action of weak intrinsic birefringence and self-induced birefringence. Numerical simulations show that stable operation can exist in wide ranges of parameters, and stable pulses with a full width at half-maximum as short as 55 fs can be generated. It is also shown that coherent coupling may greatly enhance mode locking in a weakly linearly birefringent fibre under optimum operation conditions.
An ASIC CAM design for associative set processors (2002)

One of the key requirements in systems for symbolic computation is the fast and efficient execution of set operations, such as addition, removal, or test for membership of an element in a given set S. Content-addressable memory (CAM) offers the potential for massive fine-grained parallelism in the implementation of these operations, yielding a potential speedup of O(l Sl). The authors describes an ASIC design of a 32*32 CMOS static CAM for use in an associative set processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fibroblast Growth Factor Inhibits Proliferation of a Highly Tumorigenic Insulin-Independent Teratoma-Derived Cell Line (1993)

The present paper examines the effect of basic fibroblast growth factor (bFGF) on the proliferation of teratoma-derived cell lines having increased tumorigenic properties isolated from the non-tumorigenic adipogenic cell line 1246. Although FGF is a mitogen for the non tumorigenic 1246 cells and for the moderately tumorigenic 1246-3A cells derived from the 1246 cells, bFGF inhibits the proliferation and DNA synthesis of the highly tumorigenic PC cells starting at concentration as low as 30 pg/ml. The inhibitory effect of FGF on PC cell growth is irreversible as demonstrated by the inability of the cells to resume proliferation once FGF is removed from the culture medium. Comparison of 125I-bFGF binding to the three cell lines was performed. Based on the Scatchard analysis of the binding data, PC cells display only low affinity class of FGF binding sites whereas 1246 and 1246-3A cells presented also high affinity binding sites. The inhibitory effect of FGF on PC cells did not go through activation of a PKC mediated pathway, which is also known to inhibit PC cell proliferation, since FGF inhibition of PC cell growth was still apparent after PKC down regulation. FGF was still able to transiently stimulate the expression of mRNA for early growth associated genes as demonstrated by c-myc and c-fos expression, although it inhibited cell proliferation on PC cells. Our data demonstrate that the highly tumorigenic teratoma cells acquire an inhibitory response for a factor which is growth stimulatory to non-tumorigenic and moderately tumorigenic cells from which they are derived.
Anti-tuberculosis activity and drug interaction with nevirapine of inhalable lipid microspheres containing rifampicin in murine model (2010)

Intranasal administration of lipid microspheres (LM) containing rifampicin (LM-RFP) exhibited the bacteriostatic effect against Mycobacterium tuberculosis H37Rv. The efficacies of intranasal LM-RFP in lung were markedly higher in immunodeficient BALB/c nude mice (p < 0.001), but not different in immunocompetent BALB/c mice (p = 1.000) compared to the results of oral rifampicin groups. When intranasal LM-RFP was given instead of oral rifampicin, the reductions of C(max) and AUC(0-3) of nevirapine were decreased from 32.2% to 11.9% and 30.5% to 12.4%, respectively. These results suggested that intranasal LM-RFP could improve the anti-tuberculosis activity in immunodeficient host and minimize drug interaction between rifampicin and nevirapine.
Laser Research Resource Centers At MIT (1987)

Two instrumentation facilities for laser-related research in physical sciences and biomedicine are in operation at the MIT Spectroscopy Laboratory. This article describes their organization, resources and performance.
Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. (1998)

Taxoids and other microtubule-damaging drugs are known to induce Bcl2 phosphorylation at the G2-M phase of the cell cycle, with concomitant apoptosis in malignant cells derived from a variety of human malignancies, including leukemia, lymphoma, and breast and prostate cancer. We have investigated the ability of another antineoplastic drug, dolastatin 10, in inducing Bcl2 phosphorylation and apoptosis. We also investigated the effects of a phosphatase inhibitor okadaic acid in the regulation of Bcl2 phosphorylation, cell cycle arrest, and programmed cell death. Moreover, site-directed mutagenesis studies were performed to determine the specific serine residue(s) responsible for drug-induced Bcl2 phosphorylation. Our results indicate that these antimicrotubule agents or okadaic acid can induce posttranslational modification (phosphorylation) of Bcl2 protein at multiple serine residues. Interestingly, mutation of a serine residue at position 70 to alanine can significantly decrease drug-induced posttranslational modification (phosphorylation) of Bcl2 protein. Apparently, Ser70 seems to be a critical site for drug-induced posttranslational modification (phosphorylation) of the Bcl2 protein.
First Row Transition Metal Complexes of 1-Methylcyclobutenedione, a Monosubstituted Squarate Ligand (1999)

Reaction of 1-methylcyclobutenedione with M(NO3)2·xH2O [M = Co (1) and Ni (2)] produces isomorphous polymeric complexes of formula M(CH3C4O3)(NO3)(H2O)4·2H2O that crystallize in the monoclinic space group P21/m (No. 11) with, for 1, a = 6.409(5) Å, b = 14.717(10) Å, c = 7.259(6) Å, β = 114.73(4)°, and Z = 2 (the metal atom being positioned on a center of symmetry). In both cases, adjacent metal centers are bridged μ-1,3 by the 1-methylcyclobutenedione ligand, which exhibits distinct multiple bond localization. The positive charges on the polymer chains are in each case balanced by nitrate ions. The metal atoms are six-coordinate with trans-oriented 1-methylcyclobutenedione ligands, and with four aqua ligands completing the coordination sphere. Reduction of the crystallization temperature, however, resulted, with Co, in the formation of the monomeric complex Co(CH3C4O3)2·4H2O (4). Isomorphous Mn (3), Cu (5), and Zn (6) analogues have also been synthesized. These crystallize in the monoclinic space group P21/n (No. 14) with, for 3, a = 8.8258(8) Å, b = 16.1527(14) Å, c = 9.9084(8) Å, β = 93.230(7)°, and Z = 4. The central metal atom in each of these compounds is six-coordinate, being bound to two trans-oriented 1-methylcyclobutenedione ligands and four aqua ligands, the former coordinating in a monodentate fashion via the oxygen atom trans to the methyl substituent. In both the polymeric and monomeric complexes extensive three-dimensional hydrogen-bonded networks are formed in the solid state.
Fine-grained supply gating through hypergraph partitioning and Shannon decomposition for active power reduction (2008)

Energy-efficient performance has emerged as the key design objective of high-performance logic circuits to address power-induced reliability concerns and battery life requirements in portable devices. In the sub-65nm technology regime, these problems continue to grow as leakage power becomes the predominant form of power consumption. Among numerous power reduction techniques employed at the circuit and architectural levels, supply gating has been proven to be very effective for standby power reduction. In this paper, we propose application of fine-grained supply gating to large complex circuits for active leakage and dynamic power reduction. A design methodology and associated CAD tool is developed to synthesize combinational logic using hypergraph partitioning and Shannon decomposition, which reduces both leakage and switching power by disabling unused logic dynamically in small clusters of gates. Simulation results for a set of ISCAS-85 benchmarks show that the proposed approach can achieve up to 40% saving in total power in active mode (and up to 37% saving in standby power) with negligible impact on performance and die area for a predictive 32 nm technology.
ChemInform Abstract: Synthesis and Discovery of 2,3‐Dihydro‐3,8‐diphenylbenzo[1,4]oxazines as a Novel Class of Potent Cholesteryl Ester Transfer Protein Inhibitors. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figures 1-3 from Cosilencing of <i>PKM-2</i> and <i>MDR-1</i> Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer (2023)

&lt;p&gt;Supplementary Figures 1-3. Supplementary Figure 1: Safety analysis in SKOV-3WT tumor bearing mice that had single and combination treatments of siRNA and PTX; Supplementary Figure 2: H&amp;E staining for SKOV-3WT tumor bearing mice that had single and combination treatments of siRNA and PTX (A) Liver tissue, (B) Kidney and (C) Spleen; Supplementary Figure 3: Alteration in HA-PEI/PEG:EGF ratio on siMDR-1 transfection efficiency.&lt;/p&gt;