gebhart/patrepeval huggingface dataset:
The Zinc-Finger Domain Containing Protein ZC4H2 Interacts with TRPV4, Enhancing Channel Activity and Turnover at the Plasma Membrane (2020)

The Ca<sup>2+</sup>-permeable Transient Receptor Potential channel vanilloid subfamily member 4 (TRPV4) is involved in a broad range of physiological processes, including the regulation of systemic osmotic pressure, bone resorption, vascular tone, and bladder function. Mutations in the <i>TRPV4</i> gene are the cause of a spectrum of inherited diseases (or TRPV4-pathies), which include skeletal dysplasias, arthropathies, and neuropathies. There is little understanding of the pathophysiological mechanisms underlying these variable disease phenotypes, but it has been hypothesized that disease-causing mutations affect interaction with regulatory proteins. Here, we performed a mammalian protein-protein interaction trap (MAPPIT) screen to identify proteins that interact with the cytosolic N terminus of human TRPV4, a region containing the majority of disease-causing mutations. We discovered the zinc-finger domain-containing protein ZC4H2 as a TRPV4-interacting protein. In heterologous expression experiments, we found that ZC4H2 increases both the basal activity of human TRPV4 as well as Ca<sup>2+</sup> responses evoked by ligands or hypotonic cell swelling. Using total internal reflection fluorescence (TIRF) microscopy, we further showed that ZC4H2 accelerates TRPV4 turnover at the plasma membrane. Overall, these data demonstrate that ZC4H2 is a positive modulator of TRPV4, and suggest a link between TRPV4 and ZC4H2-associated rare disorders, which have several neuromuscular symptoms in common with TRPV4-pathies.
Table S3 from NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model (2023)

&lt;p&gt;List of hits in the top 10% of screen hits from NCI-H69 and GLC-16 xenograft tumors&lt;/p&gt;
Bitfiltrator: A general approach for reverse-engineering Xilinx bitstream formats (2022)

As the usage of FPGAs spreads, engineers will inevitably employ them in ways unforeseen-or unwanted-by their manufacturers. Xilinx's toolchains offer multiple points for customizing the FPGA compilation flow, but all flows must end with Vivado as it is the only tool capable of generating the bitstream to program an FPGA. Xilinx does not document its bitstream format, so users who wish to bypass Vivado and modify a bitstream directly must reverse-engineer it to discover the location and format of cells. Prior work has reverse-engineered parts of the bitstream format for security or debugging/instrumentation activities, but no paper has explained how to do this reverse engineering systematically! Code from prior efforts (when available) is hard-coded to reverse engineer a specific device and is difficult or impossible to use for another one. These efforts-focused on applications instead of reverse-engineering-compel engineers who need to modify a bitstream to rediscover unwritten practice. Our work bridges this gap by explaining: (1) the various parameters needed to navigate a bitstream correctly, (2) the experiments to obtain them, and (3) the many pitfalls and erroneous assumptions to avoid while undertaking this endeavor. We demonstrate our technique by using it to extract the bitstream format of initial LUT equations, LUTRAM contents, BRAM contents, and register values in Xilinx UltraScale and UltraScale+ FPGAs. Our methods are implemented in an open-source tool, Bitfiltrator [1], that can extract device layouts and architecture-specific bitstream formats for these cells automatically and without physical access to an FPGA.
Rotierende Wellen gegen Kühlschmierstoff und Partikel berührungsfrei abdichten (2003)

Die Anforderungen an die arbeitsseitige Spindelabdichtung steigen immer weiter. Ursache dafür sind die immer höheren Zerspanungsleistungen moderner Werkzeugma-schinen. Neue Zerspanungstechnologien wie beispielsweise die Trockenbearbeitung führen zu einer trockenen Feststoffbeaufschlagung der Dichtsysteme und damit zu einer neuen Abdichtaufgabe. Übergeordnetes Ziel der Arbeit sind abgesicherte Gestaltungsrichtlinien für berührungsfreie Wellendichtsysteme bei extremen Beaufschlagungsbedingungen durch Kühlschmierstoff und/oder Feststoffe. Das Verschmutzungsverhalten von Fangkammerdichtsystemen kann durch die erarbei-teten Gestaltungshinweise deutlich verbessert werden. Bei geeignet ausgelegten und gestalteten Sperrluftdichtsystemen gibt es keinen Eindringstrom in das Dichtsystem, der zu Feststoffablagerungen im Innenbereich der Dichtung führt. Trockene Feststoffe können nicht mit reinen Fangkammerdichtsystemen abgedichtet werden. Dahingegen kann mit Sperrluftdichtsystemen, unabhängig von der Beaufschla-gungsart (trockene Feststoffe, Feststoff-Flüssigkeitsgemische oder extreme Flüssig-keitsbeaufschlagung), bei identischer Dichtsystemgestaltung eine berührungsfreie Dichtwirkung erzielt werden. Die erarbeiteten Gestaltungshinweise und das maßstäbliche Konstruktionsbeispiel einer Sperrluftdichtung für eine fettgeschmierte Spindellagerung erleichtern eine effiziente Gestaltung berührungsfreier Spindeldichtsysteme. Die vorgestellte Berechnungssyste-matik ermöglicht eine einfache Abschätzung der Betriebsparameter von Sperrluftdichtsystemen.
Low frequency noise in vortex spin torque nano-oscillators (2018)

With their very rich static and dynamical properties, magnetic vortex dynamics excited by a spin polarized current represent not only a model system to study the physical mechanisms of spin transfer phenomena but could also give birth to a new generation of multi-functional microwave spintronic devices [1]. The key property of spin-torque nano-oscillators (STNOs) is their high nonlinearity [2] which gives rise to manifold phenomena such as injection locking to an external rf signal [3], [4] or synchronization of multiple STNOs [5]–[7]. On the other hand, their large nonlinearity causes the oscillator's very poor spectral coherence and leads to a coupling between amplitude and phase noise [8]. While the noise distribution for offset frequencies far from the carrier frequency is reasonably well understood [8] and described by the general nonlinear autooscillator theory [2], low frequency noise remains under investigation as it limits the frequency stability of the oscillator. Extensively studied in GMR and TMR sensors [9]–[12], this work addresses the low frequency noise of a TMR-based spin-torque vortex oscillator in the regime of large amplitude steady oscillations. In detail, we present a precise experimental study of the TMR-based spin-torque vortex oscillator's low frequency noise, which remains poorly investigated for STNOs in the regime of large amplitude steady oscillations, as we propose here. The measured STNO's magnetic tunnel junction layer stack of PtMn/CoFe/Ru/ CoFeB/CoFe/MgO/FeB/MgO/Ta/Ru was realized by sputter deposition and nanopillar devices of 100–600nm were nanofabricated. The devices have a free running frequency from 100 MHz to 1 GHz depending on the diameter and the applied field value, with an integrated power of up to a few $\mu \mathrm {W}$ and a linewidth of typically $\sim 100$ kHz. In complement to the experimental measurements, we have also developed a phenomenological theory aiming to investigate the low frequency flicker noise in these vortex-STNOs. Starting from the corresponding nonlinear Langevin equations and a colored noise distribution, we find additional noise contributions to the white noise power spectral densities. This also gives an additional coupling term between amplitude and phase noise. Noteworthy, we find that this prediction agrees well to our experimental results of the gyrotropic mode's low frequency noise (Fig. (a)). Furthermore, we analyze the noise dependence on the control parameter (the operating dc current) and the oscillator's active magnetic volume, reflected by the Hooge-formula for TMR sensors [12] and the oscillator's nonlinearity itself (Fig. (b)). S.W. acknowledges financial support from Labex FIRST-TF. EU FP7 grant (MOSAIC No. ICT-FP7–8.317950) is also acknowledged for support.
Performance study of fast BSS transition using IEEE 802.11r (2006)

The mass deployment of IEEE 802.11 based wireless local area networks (WLAN), and increased sales in portable devices supporting WLAN, have resulted in an urgent need to support real time applications while wireless users are on the move. This critical support necessitates research into current WLAN roaming capabilities. This paper discusses how WLAN roaming capabilities are affected by new standards such as security (IEEE 802.11i) and quality of service (IEEE 802.11e), and describes the new IEEE 802.11r standard, which was developed to address issues faced by real time applications that implement the security and quality of service enhancements. The performance evaluation of 802.11r prototype and the 802.11i baseline mechanisms show that a voice application using 802.11r can achieve significantly shorter transition time and reduced packet loss during AP-AP transition, and can therefore realize a noticeable improvement in voice quality.
Mechanistic Study of a Pd/C‐Catalyzed Reduction of Aryl Sulfonates Using the Mg—MeOH—NH4OAc System. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silicon-organic hybrid (SOH) IQ modulator using the linear electro-optic effect for transmitting 16QAM at 112 Gbit/s (2013)

Advanced modulation formats call for suitable IQ modulators. Using the silicon-on-insulator (SOI) platform we exploit the linear electro-optic effect by functionalizing a photonic integrated circuit with an organic χ(2)-nonlinear cladding. We demonstrate that this silicon-organic hybrid (SOH) technology allows the fabrication of IQ modulators for generating 16QAM signals with data rates up to 112 Gbit/s. To the best of our knowledge, this is the highest single-polarization data rate achieved so far with a silicon-integrated modulator. We found an energy consumption of 640 fJ/bit.
Enhanced carrier confinement effect by the multiquantum barrier in 660 nm GaInP/AlInP visible lasers (1991)

Multiquantum barriers (MQBs) were introduced into 660 nm GaInP/AlInP lasers with superlattice confinement (SLC) layers, resulting in drastic improvements in lasing performance. Lowest threshold current densities (840 A/cm2) and highest room-temperature values for T0 (167 K) ever reported for 660–680 nm range lasers with bulk active layers were achieved. High-temperature characteristics of the threshold current densities were measured in order to investigate the enhanced carrier confinement effect of MQBs and to estimate the excess nonradiative recombination current component. From the temperature dependence on the excess current density, the activation energies E0 of nonradiative processes were estimated to be 0.45 eV for MQB-SLC lasers, and 0.26 eV for conventional SLC lasers without MQB. The increase of E0 demonstrates the enhanced heterobarrier effect by MQBs.
Learning an Interactive Segmentation System (2009)

Many successful applications of computer vision to image or video manipulation are interactive by nature. However, parameters of such systems are often trained neglecting the user. Traditionally, interactive systems have been treated in the same manner as their fully automatic counterparts. Their performance is evaluated by computing the accuracy of their solutions under some fixed set of user interactions. This paper proposes a new evaluation and learning method which brings the user in the loop. It is based on the use of an active robot user - a simulated model of a human user. We show how this approach can be used to evaluate and learn parameters of state-of-the-art interactive segmentation systems. We also show how simulated user models can be integrated into the popular max-margin method for parameter learning and propose an algorithm to solve the resulting optimisation problem.
Figure S6 1H NMR of compound Re(CO)3L2 from Synthesis of novel technetium-99 m tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation (2019)

HBED-CC (<i>N,N'</i>-Bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-<i>N,N'</i>-diacetic acid, <b>L<sub>1</sub></b>) is a common bifunctional chelating agent in preparation of <sup>68</sup>Ga-radiopharmaceuticals. Due to its high stability constant for the Ga<sup>3+</sup> complex (logK<sub>GaL</sub> = 38.5) and its acyclic structure, it is well known for a rapid and efficient radiolabelling at ambient temperature with Gallium-68 and its high <i>in vivo</i> stability. [<sup>99 m</sup>Tc][Tc(CO)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]<sup>+</sup> is an excellent precursor for radiolabelling of biomolecules. The aim of this study was to develop a novel preparation method of <sup>99 m</sup>Tc-HBED-CC complexes. In this study, HBED-CC-NI (2,2'-(ethane-1,2-diylbis((2-hydroxy-5-(3-((2-(2-nitro-1H-imidazol-1-yl)ethyl)amino)-3-oxopropyl)benzyl)-azanediyl))-diacetic acid, <b>L<sub>2</sub></b>), a derivative of HBED-CC, was designed and synthesized. Both <b>L<sub>1</sub></b> and <b>L<sub>2</sub></b> were radiolabelled by [<sup>99 m</sup>Tc][Tc(CO)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]<sup>+</sup> successfully for the first time. In order to explore the coordination mode of metal and chelates, non-radioactive Re(CO)<sub>3</sub><b>L<sub>1</sub></b> and Re(CO)<sub>3</sub><b>L<sub>2</sub></b> were synthesized and characterized spectroscopically. Tc(CO)<sub>3</sub><b>L<sub>1</sub></b> and Tc(CO)<sub>3</sub><b>L<sub>2</sub></b> in solution were calculated by density functional theory and were analysed with radio-HPLC chromatograms. It showed that [<sup>99 m</sup>Tc]Tc(CO)<sub>3</sub><b>L<sub>2</sub></b> forms two stable diastereomers in solution, which is similar to those of [<sup>68</sup>Ga]Ga-HBED-CC complexes. Natural bond orbital analysis through the natural population charges revealed a charge transfer between [<sup>99 m</sup>Tc][Tc(CO)<sub>3</sub>]<sup>+ </sup>and <b>L<sub>1</sub></b> or <b>L<sub>2</sub></b>. The experimental results showed that tricarbonyl technetium might form stable complex with HBED-CC derivatives, which is useful for the future application of using HBED-CC as a bifunctional chelating agent in developing new <sup>99 m</sup>Tc-radiopharmaceuticals as diagnostic imaging agents.
Accounting for Emotions in Multi-Agent Modeling and Simulation Systems (2003)

In this paper we describe our work in progress for exploring the role of emotions in the behaviour and decision-making of artificial agents in modeling and simulation systems. The computational model of emotions we are using is based on a multi-level theory of emotions that accounts for the three layers identified in the human emotional system: the sensory-motor level, the schematic level and the conceptual level. Our current interest lies in modeling and simulating the impact of emotions in the workplace, both at the individual and at the group level. We are working to incorporate our model of emotions into Brahms, a multi-level modeling and simulation system being developed at NASA Ames Research Center. 1.
Notice of Removal: Full 4D functional ultrasound imaging in rodents using a matrix array (2017)

Removed.
Optimised thermal and microwave packaging for wide-band gap transistors : diamond &amp; flip chip (2005)

Wide-band gap (WBG) transistors give a real breakthrough for power devices compared to silicon (Si) and gallium arsenide (GaAs) components. However, for space applications, the high power density of WBG transistors makes the thermal management critical and requires thermal investigations. Some packaging solutions dedicated to those power transistors are presented in this paper. The focus is made on diamond-based packaging with two topologies. In the first one, the die is soldered on a diamond carrier. In the second one, it is flip chip bonded on a diamond circuit. Thermal simulations, thermal cycling and electrical measurement results are given for both configurations.
InSAR observations of the 2009 Racha earthquake, Georgia (2016)

Abstract. Central Georgia is an area strongly affected by earthquake and landslide hazards. On 29 April 1991 a major earthquake (Mw = 7.0) struck the Racha region in Georgia, followed by aftershocks and significant afterslip. The same region was hit by another major event (Mw = 6.0) on 7 September 2009. The aim of the study reported here was to utilize interferometric synthetic aperture radar (InSAR) data to improve knowledge about the spatial pattern of deformation due to the 2009 earthquake. There were no actual earthquake observations by InSAR in Georgia. We considered all available SAR data images from different space agencies. However, due to the long wavelength and the frequent acquisitions, only the multi-temporal ALOS L-band SAR data allowed us to produce interferograms spanning the 2009 earthquake. We detected a local uplift around 10 cm (along the line-of-sight propagation) in the interferogram near the earthquake's epicenter, whereas evidence of surface ruptures could not be found in the field along the active thrust fault. We simulated a deformation signal which could be created by the 2009 Racha earthquake on the basis of local seismic records and by using an elastic dislocation model. We compared our modeled fault surface of the September 2009 with the April 1991 Racha earthquake fault surfaces and identify the same fault or a sub-parallel fault of the same system as the origin. The patch that was active in 2009 is just adjacent to the 1991 patch, indicating a possible mainly westward propagation direction, with important implications for future earthquake hazards.
Draft Genome Sequence of Micrococcus luteus (Schroeter) Cohn (ATCC 12698) (2017)

ABSTRACT The actinobacterium Micrococcus luteus can be found in a wide variety of habitats. Here, we report the 2,411,958-bp draft genome sequence of the type strain M. leuteus (Schroeter) Cohn (ATCC 12698). Characteristic of this taxa, the genome sequence has a high G+C content, 73.14%.
On the Delay of Finite Buffered Multi-Hop Relay Wireless Internet of Things (2019)

The evolution of Internet of Things (IoT) as a new application in wireless networks mandates the utilization of wireless cooperative relaying to overcome the energy limitations of IoT devices. Multi-hop relaying is a communication scheme, where packets are forwarded from source to destination through intermediate relay nodes. All these relay nodes are assumed to have buffers for temporarily storing their received packets. During each time-slot, one node can be selected among all nodes to transmit and forward a single packet to the consequent relay node towards the final destination. Based on the nature of the data and its sensitivity to the delay, different schemes can be used to control the movement of packets in the multi-hop networks. This paper presents a framework for the delay analysis of buffered multi-hop networks based on a recently proposed packet-forwarding scheme that uses the best hop for transmission. Based on the channel, the best hop, having the highest signal-to-noise ratio (SNR), is selected. This hop selection procedure produces selection diversity, which minimizes the error and outage probability. The network delay is studied analytically, based on a finite-state Markov chain model. Also, we derive analytical closed form expressions for the average queue length for each relay buffer in the network and the end-to-end network delay. Finally, we compare the delay and outage of the best hop scheme with the conventional multi-hop transmission scheme. The results show how the number of intermediate relays and the buffer size of each one can affect the network delay.
TIA1 regulates the generation and response to toxic tau oligomers (2018)

RNA binding proteins (RBPs) are strongly linked to the pathophysiology of motor neuron diseases. Recent studies show that RBPs, such as TIA1, also contribute to the pathophysiology of tauopathy. RBPs co-localize with tau pathology, and reduction of TIA1 protects against tau-mediated neurodegeneration. The mechanism through which TIA1 reduction protects against tauopathy, and whether TIA1 modulates the propagation of tau, are unknown. Previous studies indicate that the protective effect of TIA1 depletion correlates with both the reduction of oligomeric tau and the reduction of pathological TIA1 positive tau inclusions. In the current report, we used a novel tau propagation approach to test whether TIA1 is required for producing toxic tau oligomers and whether TIA1 reduction would provide protection against the spread of these oligomers. The approach used young PS19 P301S tau mice at an age at which neurodegeneration would normally not yet occur and seeding oligomeric or fibrillar tau by injection into hippocampal CA1 region. We find that propagation of exogenous tau oligomers (but not fibrils) across the brain drives neurodegeneration in this model. We demonstrate that TIA1 reduction essentially brackets the pathophysiology of tau, being required for the production of tau oligomers, as well as regulating the response of neurons to propagated toxic tau oligomers. These results indicate that RNA binding proteins modulate the pathophysiology of tau at multiple levels and provide insights into possible therapeutic approaches to reduce the spread of neurodegeneration in tauopathy.
Report of the 2014 Programming Models and Environments Summit (2016)

Programming models and environments play the essential roles in high performance computing of enabling the conception, design, implementation and execution of science and engineering application codes. Programmer productivity is strongly influenced by the effectiveness of our programming models and environments, as is software sustainability since our codes have lifespans measured in decades, so the advent of new computing architectures, increased concurrency, concerns for resilience, and the increasing demands for high-fidelity, multi-physics, multi-scale and data-intensive computations mean that we have new challenges to address as part of our fundamental R&D requirements. Fortunately, we also have new tools and environments that make design, prototyping and delivery of new programming models easier than ever. The combination of new and challenging requirements and new, powerful toolsets enables significant synergies for the next generation of programming models and environments R&D. This report presents the topics discussed and results from the 2014 DOE Office of Science Advanced Scientific Computing Research (ASCR) Programming Models & Environments Summit, and subsequent discussions among the summit participants and contributors to topics in this report.
Hybrid organic–inorganic zeolites: status and perspectives (2016)

This Perspective article focuses on the recent progress and research directions in the preparation of hybrid organic–inorganic zeolites for applications in heterogeneous catalysis.
Mehrfachbindungen zwischen Hauptgruppenelementen und Übergangsmetallen, XCVI Niob‐ und Tantalkomplexe mit Imido‐Liganden (1991)

Multiple Bonds Between Main‐Group Elements and Transition Metals, XCVI. – Niobium and Tantalum Complexes Having Imido Ligands The new niobium and tantalum complexes 2b and 2c of formula M[N(SiMe 3 ) 2 ] 2 (NSiMe 3 )(OSiMe 3 ) (M = Nb, b ; Ta, c) are accessible by the reaction of the oxychlorides MOCl 3 with the lithium amide LiN[Si(CH 3 ) 3 ] 2 in 36 and 27% isolated yield, respectively.