gebhart/patrepeval huggingface dataset:
Blocked Elements in 1-D and 2-D Arrays—Part II: Compensation Methods as Applied to Large Coherent Apertures (2017)

In Part I of this paper, we detected elements blocked by ribs during simulated and in vivo transcostal liver scans, and we turned those elements OFF to compensate for the loss in visibility of liver vasculature. Here, we apply blocked-element detection and adaptive compensation to large synthetic-aperture (SA) data collected through rib samples ex vivo, in order to reduce near-field clutter and to recover lateral resolution. To construct large synthetic transmit and receive apertures, we collected the individual-channel signals from a fully sampled matrix array at multiple and known array locations across the tissue samples. The blocked elements in SAs were detected using the method presented in Part I and retroactively turned OFF, while the subapertures covering intercostal spaces were either compounded, or coherently summed using uniform and adaptive element-weighting schemes. Turning OFF the blocked elements reduced the reverberation clutter by 5 dB on average. Adaptive weighing of the nonblocked elements to rescale the attenuated spatial frequencies reduced sidelobe levels by up to 5 dB for the transcostal acquisitions, and demonstrated a potential to restore lateral resolution to the nonblocked levels. In addition, the arrival-time surfaces were reconstructed to estimate the aberration from intercostal spaces and to offer further means to compensate for the loss of focus quality in transthoracic imaging.
Abstract 4339: Progranulin (GP88) expression in thoracic maligancies (2015)

Abstract Background: GP88 (progranulin) is a growth and survival factor implicated in tumorigenesis and drug resistance for various cancers. GP88 tissue expression measured by IHC is inversely correlated with survival. We now evaluate GP88 tissue lung cancer small cell carcinoma (SCLC), non-small cell lung carcinoma (NSCLC) and mesothelioma. Methods: GP88 expression was determined by immunohistochemistry on tissue sections from normal lung, pleura, benign mesothelial proliferation, SCLC, NSCLC and mesothelioma. In the case of NSCLC, GP88 expression in tumor tissues from patients with localized (stage I-II) and locally advanced disease (IIIa-IIIb) was determined and correlated with clinical outcome disease-free survival (DFS) and overall survival (OS). Serum GP88 levels from patients with metastatic NSCLC was quantified by EIA and compared to GP88 levels from patients with COPD and from healthy individuals. Results: GP88 was significantly expressed in NSCLC (adenocarcinoma and squamous cell) and mesothelioma (epitheloid, sarcomatoid and biphasic subtypes) tumors. In contrast, normal lung tissue, benign lung disease, pleura, benign mesothelial proliferations and SCLC were negative. There was a significant increased risk of recurrence and death for patients with resected NSCLC (stage I,II) with high expression (GP88 IHC score 3+) compared to patients with GP88IHC score &amp;lt;3+, with HR = 2.28 (p = 0.0076) for DFS and HR = 2.17 (p = 0.014) for OS In locally advanced disease progression-free survival after chemoradiotherapy was inferior (HR = 2.9, p = 0.022) for GP88 scores of 3+ vs. &amp;lt;3+ In addition, patients with stage IIIb/IV NSCLC had a significantly elevated serum GP88 when compared to control subjects (49.9ng/ml vs. 28.4ng/ml, p&amp;lt;0.0001). 67% of mesothelioma tumors (stage I-III) scored positive for GP88 with 23% of tissue examined showing a GP88 score of 3+. Conclusions: This is the first study investigating GP88 expression in various thoracic malignancies. Differences of GP88 expression were observed in different lung tumor types with NSCLC and mesothelioma being positive. Correlation with clinical outcomes in NSCLC demonstrates that measuring the GP88/Progranulin IHC tumor tissue expression using the anti-GP88/PGRN 6B3 antibody provides information on the risk of recurrence and death of patients with stages I-III NSCLC and that serum GP88 levels are elevated in advanced disease. Future research will focus on investigating the prognostic potential of GP88 tissue expression and serum levels for mesothelioma patients. Citation Format: Ginette Serrero, Martin J. Edelman, Pablo Bejarano, Douglas M. Hawkins, David Hicks, David N. Reisman, Olga Ioffe, Josephine Feliciano, Binbin Yue. Progranulin (GP88) expression in thoracic maligancies. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4339. doi:10.1158/1538-7445.AM2015-4339
Abstract 2087: miR-483-3p is an oncogene involved in nephroblastoma and in adult tumors with activated β-catenin (2010)

Abstract The hsa-mir-483 locus is located within intron 2 of the IGF2 locus. Here, we show that the mature microRNA (miRNA) miR-483-3p is over-expressed and co-regulated with IGF2 in 100% of Wilms’ tumors. Additionally, several types of common adult cancers exhibit high or even extremely high levels of miR-483-3p. We show that the mutation status of the oncoprotein β-catenin is correlated with the expression of the miR-483-3p in hepatocarcinoma and colorectal cancer. These findings suggested an autonomous oncogenic function for this miRNA. Indeed, anti-microRNA oligonucleotide (AMO) against miR-483-3p could inhibit tumorigenicity of HepG2 cells. At the same time, no anti-tumor effect was elicited by inhibition of IGF2. The oncogenic properties of miR-483-3p were further supported by the finding that its ectopic expression could protect cells from apoptosis through the regulation of one important pro-apoptotic protein, Puma. Our results indicate that miR-483-3p can function as an anti-apoptotic oncogene in various human cancers and reveal a new potentially important target for anti-cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2087.
New Potential Uroselective NO-Donor α1-Antagonists (2003)

A recent uroselective alpha(1)-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor alpha(1)-antagonists. All the compounds studied proved to be potent and selective ligands of human cloned alpha(1a)-receptor subtype. Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their alpha(1A)-antagonist and their NO-donor properties.
Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia (2020)

Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated. We analyzed serum-soluble factors and miRNAs in 92 patients with PE and an equal number of healthy controls to identify new useful biomarkers for PE. Serum miR-31-5p, miR-155-5p, and miR-214-3p levels were significantly elevated in these patients and highly correlated with clinical symptoms of hypertension and proteinuria, whereas the miR-1290-3p level was decreased. The increased miRNAs were upregulated in an NF-κB-dependent manner and suppressed endothelial nitric oxide synthase (eNOS) and placental growth factor (PlGF) expression. The level of each miRNA had greater than 90% diagnostic accuracy, which was further increased by analyzing its ratio relative to that of miR-1290-3p. Taken together, the ratios of miR-31-5p, miR-155-5p, or miR-214-3p to miR-1290-3p may serve as reliable diagnostic or prognostic tools for PE, thereby providing evidence that these miRNAs are promising mechanism-based targets for designing therapeutic and preventive strategies for the clinical management of PE.
Stabile, cyclische Germandiyle („Cyclogermylene”): Herstellung, Molekülstruktur, Metallkomplexe und Thermolysen (1992)

Die neuen, bei 50°C unzersetzt sublimierenden Germandiyle 1 und 2 sind im Kristall, in Lösung und in der Gasphase monomer. Sie sind aus Germaniumdichlorid‐1,4‐Dioxan und den entsprechenden Lithiumdiamiden in hohen Ausbeuten zugänglich. Mit [Ni(CO) 4 ] reagiert 1 glatt zu 3 und 4 Nach ab‐initio‐Rechnungen weist 2 eine cyclische π‐Elektronen‐Delokalisierung auf. magnified image
An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME) (2018)

This contemporaneous international snapshot shows that uptake of the TaTME approach is widespread and is associated with surgically and pathologically acceptable results.
Detection of differentiation‐ and activation‐linked cell surface antigens on cultured mast cell progenitors (2005)

Most MC antigens may already be expressed at an early stage of mastopoiesis. Whereas IL-3R and GM-CSFRs are lost during differentiation of MC, these cells may acquire complement receptors (CD35, CD88) under the influence of distinct cytokines.
Latest developments in AlGaInN laser diode technology (2013)

The latest developments in AlGaInN laser diode technology are reviewed. The AlGaInN material system allows for laser diodes to be fabricated over a very wide range of wavelengths from u.v. to the visible, i.e., 380-530nm, by tuning the indium content of the laser GaInN quantum well. Ridge waveguide laser diode structures are fabricated to achieve single mode operation with optical powers of &gt;100mW in the 400-420nm wavelength range with high reliability. Low defectivity and highly uniform TopGaN and Ammono GaN-substrates allow arrays and bars of nitride lasers to be fabricated. In addition, high power operation of AlGaInN laser diodes is demonstrated with the operation of a single chip, ‘mini-array’ consisting of a 3 stripe common p-contact at powers up to 2.5W cw in the 408-412 nm wavelength range and a 16 stripe common p-contact laser array at powers over 4W cw.
Topological Insulator Laser Using Valley-Hall Photonic Crystals (2020)

Topological photonics has recently been proven as a robust framework for manipulating light. Active topological photonic systems, in particular, enable richer fundamental physics by employing nonlinear light-matter interactions, thereby opening a new landscape for applications such as topological lasing. Here we propose an all-dielectric topological insulator laser scheme in the telecommunication region based on semiconductor cavities formed by topologically distinct Kagome photonic crystals. Our theoretical results show that the proposed planar semiconductor Kagome lattice can lift degeneracy with geometrical perturbation and open broad photonic bandgaps, and valley-dependent edge states and topologically robust transport with subwavelength scale confinement are observed at the edge of the perturbed Kagome lattices with distinct valley Chern numbers. An interesting feature of the Kagome lattices is that it supports two different types of valley Hall edge modes, which enables the coexistence of high Q ring-resonator modes and lossy Fabry–Pérot resonator modes in the proposed topological cavities. Moreover, we explore pumping and lasing dynamics of the topological cavities by means of a four-level two-electron model and demonstrate that this model offers a powerful platform to investigate non-Hermitian topological laser cavities with arbitrary geometry. The proposed topological semiconductor scheme provides a new route to study non-Hermitian topological photonics and to develop integrated topological systems for robust light generation and transport.
Chromophore Distortions in the Bacteriorhodopsin Photocycle:  Evolution of the H−C14−C15−H Dihedral Angle Measured by Solid-State NMR (2001)

In recent years, structural information about bacteriorhodopsin has grown substantially with the publication of several crystal structures. However, precise measurements of the chromophore conformation in the various photocycle states are still lacking. This information is critical because twists about the chromophore backbone chain can influence the Schiff base nitrogen position, orientation, and proton affinity. Here, we focus on the C14-C15 bond, using solid-state nuclear magnetic resonance spectroscopy to measure the H-C14-C15-H dihedral angle. In the resting state (bR(568)), we obtain an angle of 164 +/- 4 degrees, indicating a 16 degrees distortion from a planar all-trans chromophore. The dihedral angle is found to decrease to 147 +/- 10 degrees in the early M intermediate (M(o)) and to 150 +/- 4 degrees in the late M intermediate (M(n)). These results demonstrate changes in the chromophore conformation undetected by recent X-ray diffraction studies.
Pose-NDF: Modeling Human Pose Manifolds with Neural Distance Fields (2022)

We present Pose-NDF, a continuous model for plausible human poses based on neural distance fields (NDFs). Pose or motion priors are important for generating realistic new poses and for reconstructing accurate poses from noisy or partial observations. Pose-NDF learns a manifold of plausible poses as the zero level set of a neural implicit function, extending the idea of modeling implicit surfaces in 3D to the high-dimensional domain SO(3)^K, where a human pose is defined by a single data point, represented by K quaternions. The resulting high-dimensional implicit function can be differentiated with respect to the input poses and thus can be used to project arbitrary poses onto the manifold by using gradient descent on the set of 3-dimensional hyperspheres. In contrast to previous VAE-based human pose priors, which transform the pose space into a Gaussian distribution, we model the actual pose manifold, preserving the distances between poses. We demonstrate that PoseNDF outperforms existing state-of-the-art methods as a prior in various downstream tasks, ranging from denoising real-world human mocap data, pose recovery from occluded data to 3D pose reconstruction from images. Furthermore, we show that it can be used to generate more diverse poses by random sampling and projection than VAE-based methods.
Gas-filled liposomes as ultrasound contrast agents for blood pool, thrombus-specific and therapeutic applications (1998)

Our group has developed technology for stabilizing microbubbles with phospholipid coatings (Aerosomes®-ImaRx Pharmaceutical Corp.). The first agent (MRX-115) is based upon lipid-coated microspheres filled with perfluoropropane gas and is in phase III clinical trials (October, 1997) for radiology and cardiology applications. Myocardial perfusion studies show the potential for the agent to detect ischemia in patients with myocardial infarcts. Targeting ligands have been covalently bound to lipids and incorporated into the stabilizing shells on the microbubbles. The first targeted agent planned for clinical trials is MRX-408 (perfluorobutane gas, linear hexapeptide-RGD analog). In vitro studies show enhanced visualization of thrombi, and in vivo studies in dogs with arterial and venous thrombi show selective enhancement, even in animals injected with heparin. In vitro studies have been performed to test sonothrombolysis comparing MRX-115 to MRX-408 with and without urokinase. The targeted contrast agent MRX-408 increases the rate of clot dissolution with ultrasound. Targeted, tissue-specific agents are feasible for ultrasound. A thrombus-specific ultrasound contrast agent has the potential to improve clot characterization and detection as well as clot lysis.
Fabrication of Long Lengths of Epitaxial Buffer Layers on Biaxially Textured Nickel Substrates Using a Continuous Reel‐to‐Reel Dip‐Coating Unit (2001)

A low‐cost, nonvacuum, solution precursor route has been developed to produce epitaxial oxide buffer layers of Eu 2 O 3 or La 2 Zr 2 O 7 on biaxially textured Ni (100) tapes. A reel‐to‐reel continuous dip‐coating unit consisting of a constant‐tension tape transport system attached to a controlled atmosphere furnace was fabricated. Nickel tapes were pulled through a 2‐methoxyethanol solution of europium methoxyethoxide/acetate or lanthanum zirconium methoxyethoxide. The double‐sided dip‐coated tapes were then annealed in a preheated furnace at 1000°–1100°C with a high flow rate of Ar/H 2 (4%) gas. The dip‐coated buffers were dense, continuous, crack‐free, and epitaxial with a single cube texture. A critical current ( J c ) of &gt;1 MA/cm 2 at 77 K and self‐field was obtained for YBa 2 Cu 3 O 7‐δ (YBCO) films with a layer sequence of YBCO ( ex situ BaF 2 process)/CeO 2 (sputtered)/YSZ (sputtered)/Eu 2 O 3 (dip‐coated)/nickel. We have produced 1–2 m lengths of epitaxial buffer layers on textured nickel substrates using a nonvacuum process for the first time.
Scoup-SMT: Scalable Coupled Sparse Matrix-Tensor Factorization (2013)

How can we correlate neural activity in the human brain as it responds to words, with behavioral data expressed as answers to questions about these same words? In short, we want to find latent variables, that explain both the brain activity, as well as the behavioral responses. We show that this is an instance of the Coupled Matrix-Tensor Factorization (CMTF) problem. We propose Scoup-SMT, a novel, fast, and parallel algorithm that solves the CMTF problem and produces a sparse latent low-rank subspace of the data. In our experiments, we find that Scoup-SMT is 50-100 times faster than a state-of-the-art algorithm for CMTF, along with a 5 fold increase in sparsity. Moreover, we extend Scoup-SMT to handle missing data without degradation of performance. We apply Scoup-SMT to BrainQ, a dataset consisting of a (nouns, brain voxels, human subjects) tensor and a (nouns, properties) matrix, with coupling along the nouns dimension. Scoup-SMT is able to find meaningful latent variables, as well as to predict brain activity with competitive accuracy. Finally, we demonstrate the generality of Scoup-SMT, by applying it on a Facebook dataset (users, friends, wall-postings); there, Scoup-SMT spots spammer-like anomalies.
The compensatory reserve index predicts recurrent shock in patients with severe dengue (2022)

CRI is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue.
Reversible interconversion of permethylscandocene tellurolates and tellurides. X-ray structure of [(C5Me5)2Sc]2(.mu.-Te) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible interconversion of permethylscandocene tellurolates and tellurides. X-ray structure of [(C5Me5)2Sc]2(.mu.-Te)Warren E. Piers, Leonard R. MacGillivray, and Michael ZaworotkoCite this: Organometallics 1993, 12, 12, 4723–4725Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/om00036a004https://doi.org/10.1021/om00036a004research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice (2009)

Evidence has linked genetic predisposition and environmental exposures to the worldwide pandemic of inflammatory bowel diseases (IBD), but underlying biochemical events remain largely undefined. Here, we studied the gradual development of colitis in Interleukin 10 deficient mice using a combination of (i) histopathological analysis of intestinal sections, (ii) metabolic profiling of blood plasma, and (iii) measurement of plasma inflammatory biomarkers. Data integration using chemometric tools, including Independent Component Analysis, provided a new strategy for measuring and mapping the metabolic effects associated with the development of intestinal inflammation at the age of 1, 8, 16, and 24 weeks. Chronic inflammation appeared at 8 weeks and onward, and was associated with altered cecum and colon morphologies and increased inflammatory cell infiltration into the mucosa and the submucosa. Blood plasma profiles provided additional evidence of loss of energy homeostasis, impaired metabolism of lipoproteins and glycosylated proteins. In particular, IL-10-/-mice were characterized by decreased levels of VLDL and increased concentrations of LDL and polyunsaturated fatty acids, which are related to the etiology of IBD. Moreover, higher levels of lactate, pyruvate, citrate and lowered glucose suggested increased fatty acid oxidation and glycolysis, while higher levels of free amino acids reflected muscle atrophy, breakdown of proteins and interconversions of amino acids to produce energy. These integrated system investigations demonstrate the potential of metabonomics for investigating the mechanistic basis of IBD, and it will provide novel avenues for management of IBD.
Recovering Device Sensitivities with Quadratic Programming (1998)

To accurately predict the response of colour devices such as digital cameras to spectral stimuli their spectral sensitivities need to be known. In this paper we present a simple, flexible method for characterising such devices, based on a single image of aMacbeth Color Checker Chart.We begin by showing that device RGBs are linearly related to the Macbeth reflectances and that this linear relationship is defined by the spectral sensitivities of the device. It follows then that it should be possible to solve for these sensitivities by linear regression. However, this simple idea does notwork well in practice - recovered sensitivities are very different from the actual device sensitivities.The simple regression fails because the Macbeth reflectance set has limited dimensionality and so the regression is highly sensitive to image noise. To overcome this problem we incorporate a number of natural constraints: positivity, modality, and band-limitedness into the regression formulation. Each constraint can be written as a linear inequality and so solving for device sensitivities by this constrained regression is a quadratic programming problem. Posing the problem in this form, we can search for the sensors which best fit the data, quickly and efficiently, by trying different combinations of the linear constraints.The results of performing this constrained regression on a number of colour devices are presented here. In all cases our new technique recovers sensors which are very close to the actual device sensitivities and we are confident that these results will extrapolate to other colour devices.
Reconstructing polarimetric information from existing intravascular optical frequency domain imaging data (2023)

Using the inherent properties of existing clinical intravascular OFDI systems, we present a robust signal processing software which resolves the polarization properties of coronary plaques and apply this method to existing patient datasets.