gebhart/patrepeval huggingface dataset:
685: A Short Hairpin RNA Targeting Pin (Protein Inhibitor of NOS) is More Efficient than the Anti-Sense Pin RNA for Gene Therapy of Aging-Related Erectile Dysfunction in the RAT (2007)

You have accessJournal of UrologyModerated Poster 20, Monday, May 21, 2007, 8:00 - 10:00 am1 Apr 2007685: A Short Hairpin RNA Targeting Pin (Protein Inhibitor of NOS) is More Efficient than the Anti-Sense Pin RNA for Gene Therapy of Aging-Related Erectile Dysfunction in the RAT Thomas R. Magee, Istvan Kovanecz, Liliana Cantini, Monica G. Ferrini, Dolores Vernet, Hugo H. Davila, Jacob Rajfer, and Nestor F. Gonzalez-Cadavid Thomas R. MageeThomas R. Magee More articles by this author , Istvan KovaneczIstvan Kovanecz More articles by this author , Liliana CantiniLiliana Cantini More articles by this author , Monica G. FerriniMonica G. Ferrini More articles by this author , Dolores VernetDolores Vernet More articles by this author , Hugo H. DavilaHugo H. Davila More articles by this author , Jacob RajferJacob Rajfer More articles by this author , and Nestor F. Gonzalez-CadavidNestor F. Gonzalez-Cadavid More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30925-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "685: A Short Hairpin RNA Targeting Pin (Protein Inhibitor of NOS) is More Efficient than the Anti-Sense Pin RNA for Gene Therapy of Aging-Related Erectile Dysfunction in the RAT." The Journal of Urology, 177(4S), p. 230 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 230 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Thomas R. Magee More articles by this author Istvan Kovanecz More articles by this author Liliana Cantini More articles by this author Monica G. Ferrini More articles by this author Dolores Vernet More articles by this author Hugo H. Davila More articles by this author Jacob Rajfer More articles by this author Nestor F. Gonzalez-Cadavid More articles by this author Expand All Advertisement Loading ...
Backside-illuminated high-current photodiode for analog optical links (2008)

We fabricated a backside-illuminated high-current InGaAs/InP photodiode, and demonstrated an RF power of 25.8 dBm at 5 GHz. The third-order intercept point was 34.2 dBm at the photocurrent of 100 mA, 5.2 GHz.
A multiphase DC/DC converter with hysteretic voltage control and current sharing (2003)

An interleaving technique and hysteretic voltage control are suitable for low-voltage, high-current, fast-response power supplies. In this paper, a multiphase DC/DC power converter employing interleave and hysteretic control techniques and current sharing is proposed. The design considerations are discussed. Simulation and experimental results are reported.
Magnetic field response of doubly clamped magnetoelectric microelectromechanical AlN-FeCo resonators (2017)

Magnetoelectric (ME) cantilever resonators have been successfully employed as magnetic sensors to measure low magnetic fields; however, high relative resolution enabling magnetometry in high magnetic fields is lacking. Here, we present on-chip silicon based ME microelectromechanical (MEMS) doubly clamped resonators which can be utilized as high sensitivity, low power magnetic sensors. The resonator is a fully suspended thin film ME heterostructure composed of an active magnetoelastic layer (Fe0.3Co0.7), which is strain coupled to a piezoelectric signal/excitation layer (AlN). By controlling uniaxial stress arising from the large magnetoelastic properties of magnetostrictive FeCo, a magnetically driven shift of the resonance frequency of the first fundamental flexural mode is observed. The theoretical intrinsic magnetic noise floor of such sensors reaches a minimum value of 35 pT/Hz. This approach shows a magnetic field sensitivity of ∼5 Hz/mT in a bias magnetic field of up to 120 mT. Such sensors have the potential in applications required for enhanced dynamic sensitivity in high-field magnetometry.
ChemInform Abstract: Nickel(II)‐Promoted Rearrangements of Some N‐Substituted Porphyrins. (1987)

Abstract The N‐methoxycarbonylmethylporphyrin (Ia), obtained by standard procedures, rearranges in the presence of nickel(II)‐compounds to give a mixture of the isomeric meso‐substituted nickel(II) porphyrins (IIb) and (IIc); a minor amount of the N‐unsubstituted complex (IIa) is also formed.
In-Silico Evaluation of an Iterative Pace-Mapping Technique to Guide Catheter Ablation of Ventricular Ectopy (2019)

Ventricular tachychardia (VT) is one of the mechanisms that induce sudden cardiac death. A way to cure VT is to ablate the exit site with an endocardial catheter. But it can be difficult, and sometimes impossible, to localize this exit site accurately enough.
Development of a CT-Compatible, Anthropomorphic Skull and Brain Phantom for Neurosurgical Planning, Training, and Simulation (2022)

A realistic and CT-compatible anthropomorphic head phantom was designed and successfully used for simulated augmented reality-led neurosurgical procedures. The anatomic details of the skull base and brain were realistically reproduced. This phantom can easily be manufactured and used for surgical training at a low cost.
Stiffness reconstruction methods for MR elastography (2018)

Assessment of tissue stiffness is desirable for clinicians and researchers, as it is well established that pathophysiological mechanisms often alter the structural properties of tissue. Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, including staging liver fibrosis and stratifying breast cancer malignancy. A vital component of MRE consists of the reconstruction algorithms used to derive stiffness from wave-motion images by solving inverse problems. A large range of reconstruction methods have been presented in the literature, with differing computational expense, required user input, underlying physical assumptions, and techniques for numerical evaluation. These differences, in turn, have led to varying accuracy, robustness, and ease of use. While most reconstruction techniques have been validated against in silico or in vitro phantoms, performance with real data is often more challenging, stressing the robustness and assumptions of these algorithms. This article reviews many current MRE reconstruction methods and discusses the aforementioned differences. The material assumptions underlying the methods are developed and various approaches for noise reduction, regularization, and numerical discretization are discussed. Reconstruction methods are categorized by inversion type, underlying assumptions, and their use in human and animal studies. Future directions, such as alternative material assumptions, are also discussed.
(Glutathiomethyl)glyoxal: mirror-image catalysis by glyoxalase I (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(Glutathiomethyl)glyoxal: mirror-image catalysis by glyoxalase IJohn W. Kozarich and Ravi V. J. ChariCite this: J. Am. Chem. Soc. 1982, 104, 9, 2655–2657Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://pubs.acs.org/doi/10.1021/ja00373a062https://doi.org/10.1021/ja00373a062research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crystal structure of a 1:1 complex between netropsin and d(CGCAATTGCG)2 (1996)

MACROMOLECULESthe orphaned 3U-tem1inal end in the minor groove of the adjacent duplex where it synm1etrically pairs with the 5'-terminal guanine to form a d[G*(G.C)] base-tliplet.Our findings extend to the minor groove a DNA hydrogen bonding pattem which permits basepair recognition dming homologous recombination.(I l ACCGGTACCGGT P4 3 , (40.2, 40.2, 57.6 A). !, 2.8 A (2) ACCGACGTCGGT Pl,(40.5,40.1.40.5A, 82.6.116.2.80.7°),3,2.6A(3) ACCGACGTCGGT R3, (63.1, 63.1, 44.5 A), 1, 2.1 A (4) ACCGACGruCGGT Pl. (40.3,40.3.40.2 A, 87.1,87.3,68.0°),3,3.2A(5) CCGACCGACGTCGGTCG, R3, (100.7,100.7, 79.8 A), 3. S.OA
Differential Operators, Gauges, and Mixed Hodge Modules (2022)

The purpose of this paper is to develop a new theory of gauges in mixed characteristic. Namely, let $k$ be a perfect field of characteristic $p&gt;0$ and $W(k)$ the $p$-typical Witt vectors. Making use of Berthelot's arithmetic differential operators, we define for a smooth formal scheme $\mathfrak{X}$ over $W(k)$, a new sheaf of algebras $\widehat{\mathcal{D}}_{\mathfrak{X}}^{(0,1)}$ which can be considered a higher dimensional analogue of the (commutative) Dieudonne ring. Modules over this sheaf of algebras can be considered the analogue (over $\mathfrak{X}$) of the gauges of Ekedahl and Fontain-Jannsen. We show that modules over $\widehat{\mathcal{D}}_{\mathfrak{X}}^{(0,1)}$ admit all of the usual $\mathcal{D}$-module operations, and we prove a robust generalization of Mazur's theorem in this context. Finally, we show that an integral form of a mixed Hodge module of geometric origin admits, after a suitable $p$-adic completion, the structure of a module over $\widehat{\mathcal{D}}_{\mathfrak{X}}^{(0,1)}$. This allows us to prove a version of Mazur's theorem for the intersection cohomology and the ordinary cohomology of an arbitrary quasiprojective variety defined over a number field.
Sortases make pili from three ingredients (2008)

Many bacterial pathogens have evolved hair-like extensions that project from their surfaces and enable adhesion to host tissues, formation of biofilms, motility, and even transfer of genetic material (1). Gram-positive bacteria use sortases, membrane-anchored transpeptidases, to cleave precursor proteins at cognate recognition motifs within C-terminal sorting signals and assemble pili in their cell wall envelope (2, 3). The transient product of this reaction is an acyl enzyme that, depending on the sortase involved, is relieved by a specific nucleophile (4). Currently studied sortases accept only one nucleophile to complete their transpeptidation reaction (5–8). For example, sortase A of Staphylococcus aureus forms an acyl enzyme with surface proteins bearing LPXTG motif sorting signals, which are subsequently relieved by the nucleophilic attack of the amino group of lipid II, the precursor of peptidoglycan synthesis in bacteria (9, 10). In this issue of PNAS, Mandlik et al. (11) provide new insight into sortases and their complicated recipes for pilus assembly.
Contribution of Direct Heating, Thermal Conduction and Perfusion During Radiofrequency and Microwave Ablation (2007)

Both radiofrequency (RF) and microwave (MW) ablation devices are clinically used for tumor ablation. Several studies report less dependence on vascular mediated cooling of MW compared to RF ablation. We created computer models of a cooled RF needle electrode, and a dipole MW antenna to determine differences in tissue heat transfer.We created Finite Element computer models of a RF electrode (Cooled needle, 17 gauge), and a MW antenna (Dipole, 13 gauge). We simulated RF ablation for 12 min with power controlled to keep maximum tissue temperature at 100 masculineC, and MW ablation for 6 min with 75 W of power applied. For both models we considered change in electric and thermal tissue properties as well as perfusion depending on tissue temperature. We determined tissue temperature profile at the end of the ablation procedure and calculated effect of perfusion on both RF and MW ablation.Maximum tissue temperature was 100 masculineC for RF ablation, and 177 masculineC for MW ablation. Lesion shape was ellipsoid for RF, and tear-drop shaped for MW ablation. MW ablation is less affected by tissue perfusion mainly due to the shorter ablation time and higher tissue temperature, but not due to MW providing deeper heating than RF. Both MW and RF applicators only produce significant direct heating within mm of the applicator, with most of the ablation zone created by thermal conduction.Both RF and MW applicators only directly heat tissue in close proximity of the applicators. MW ablation allows for higher tissue temperatures than RF since MW propagation is not limited by tissue desiccation and charring. Higher temperatures coupled with lower treatment times result in reduced effects of perfusion on MW ablation.
Wireless Multimedia Sensor Networks: Applications and Testbeds Networktestbedsallowtheeffectivenessofalgorithmsandprotocolstobeevaluatedby providing a controlled environment for measuring network performance. (2008)

The availability of low-cost hardware is enabling the development of wireless multimedia sensor networks (WMSNs), i.e., networks of resource-constrained wireless devices that can retrieve multimedia content such as video and audio streams, still images, and scalar sensor data from the environ- ment. In this paper, ongoing research on prototypes of multi- media sensors and their integration into testbeds for experimental evaluation of algorithms and protocols for WMSNs are described. Furthermore, open research issues and future research directions, both at the device level and at the testbed level, are discussed. This paper is intended to be a resource for researchers interested in advancing the state-of-the-art in experimental research on wireless multimedia sensor networks.
A Fully On-Chip PT-Invariant Transconductor (2014)

This brief presents a novel process and temperature (PT)-invariant transconductor, fabricated and tested in 180-nm CMOS technology. It uses a novel bias circuit for implementing a PT-invariant transconductor using a MOSFET in triode region. Measurements show that the transconductance varies only by ±3.4% across 18 fabricated chips and over temperatures ranging from 25 °C to 100 °C. Simulations show that variation of the transconductance across process corners is ±6.7% and across temperature range of 0 °C to 100 °C is ±1.6%. The proposed PT-invariant transconductor has the minimum variation among the fully on-chip transconductors reported so far. The proposed circuit consumes 136 μW of power.
Ultra-compact silicon nanophotonic modulator based on electro-optic polymer infiltrated slot photonic crystal waveguide (2010)

We experimentally demonstrate a Mach-Zehnder modulator based on electro-optic (EO) polymer (AJ-CKL1/PMMA) infiltrated photonic crystal slot waveguide. The modulator design combines the advantage of excellent optical confinement in silicon slot waveguide, slow light enhancement in photonic crystal waveguide, and strong electro-optical response in EO polymer. This design allows us to achieve electro-optic modulation in active region only 352&#956;m long. Matching the mode profile and group velocity between strip and photonic crystal slot waveguide enables coupling into slow light regime. The modulator shows a 22V switching voltage and an improved in-device EO coefficient of 51pm/V as compared to recently reported value.
Synthesis of C-11 Methyl-Substituted Benzocycloheptapyridine Inhibitors of Farnesyl Protein Transferase (1999)

[formula: see text] Synthesis of C-11 methyl-substituted benzocycloheptylpyridine tricyclic compounds has been achieved via two different methods. Methylation of C-11 has been effected by treatment of amine 4 with BuLi followed by Mel quenching. In a similar procedure, introduction of a C-11 substituent with concomitant rearrangement of the exocyclic double bond has been carried out. Potent farnesyl protein transferase inhibitors have been synthesized using the above methodologies.
Advances and challenges in vector modulation technologies (2008)

This paper describes recent progress of high-speed vector optical modulation technologies based on Mach- Zehnder interferometer devices. Multi-level quadrature amplitude modulation signal can be synthesized by using parallel Mach-Zehnder modulators. We can generate complicated multi-level optical signals from binary data streams, where binary modulated signals are vectorially summed in optical circuits. Modulation speed can be higher than 80 Gbaud by using a dual parallel Mach-Zehnder modulator with thin lithium niobate substrate.
Suppression of Stimulated Brillouin Scattering using Off-Axis Twisted Core Fiber (2018)

We propose a method of suppression of Brillouin scattering by using offset-core twisted fiber. A 5.2dB increase in SBS-threshold is observed by offsetting the fiber-core from center by 35µm and winding in a 45-mm spool.
Seven neurons memorizing sequences of alphabetical images via spike-timing dependent plasticity (2015)

An artificial neural network, such as a Boltzmann machine, can be trained with the Hebb rule so that it stores static patterns and retrieves a particular pattern when an associated cue is presented to it. Such a network, however, cannot effectively deal with dynamic patterns in the manner of living creatures. Here, we design a dynamic Boltzmann machine (DyBM) and a learning rule that has some of the properties of spike-timing dependent plasticity (STDP), which has been postulated for biological neural networks. We train a DyBM consisting of only seven neurons in a way that it memorizes the sequence of the bitmap patterns in an alphabetical image "SCIENCE" and its reverse sequence and retrieves either sequence when a partial sequence is presented as a cue. The DyBM is to STDP as the Boltzmann machine is to the Hebb rule.
A Different View of “Auditory Processing Factors in Language Disorders” (1975)

No AccessJournal of Speech and Hearing DisordersLetters to the Editor1 Aug 1975A Different View of “Auditory Processing Factors in Language Disorders” Paula Tallal Paula Tallal Johns Hopkins Medical School, J. F. Kennedy Institute, Baltimore, Maryland Google Scholar More articles by this author https://doi.org/10.1044/jshd.4003.413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "A Different View of “Auditory Processing Factors in Language Disorders”." Journal of Speech and Hearing Disorders, 40(3), pp. 413–414 Additional Resources FiguresReferencesRelatedDetailsCited by Neuroscience & Biobehavioral Reviews1 Jun 2020Auditory Processing Deficit in Individuals with Dyslexia: A Meta-Analysis of Mismatch NegativityChanyuan Gu and Hong-Yan Bi Psychophysiology48:8 (1107-1118)1 Aug 2011Children with dyslexia reveal abnormal native language representations: Evidence from a study of mismatch negativityJennifer Bruder, Paavo H. T. Leppänen, Jürgen Bartling, Valéria Csépe, Jean-Francois Démonet and Gerd Schulte-Körne Frontiers in Human Neuroscience126 Jun 2018Training in Temporal Information Processing Ameliorates Phonetic IdentificationAneta Szymaszek, Anna Dacewicz, Paulina Urban and Elzbieta Szelag Volume 40Issue 3August 1975Pages: 413-414 Get Permissions Add to your Mendeley library HistoryReceived: Dec 12, 1974 Published in issue: Aug 1, 1975PubMed ID: 1234956 Metrics Topicsasha-topicsleader-topicsCopyright & PermissionsCopyright © 1975 American Speech-Language-Hearing AssociationPDF downloadLoading ...
Bifocal intracranial germinoma : is biopsy still mandatory ? (2013)

peer reviewed
A DoD Injector Applicable to High-Viscosity Materials in High-Temperature (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Tissue Handling and Specimen Preparation in Surgical Pathology: Issues Concerning the Recovery of Nucleic Acids From Formalin-Fixed, Paraffin-Embedded Tissue (2008)

Development of RNA-based assays from formalin-fixed, paraffin-embedded tissue is feasible. Greater attention to tissue handling and processing is essential to improve the quality of biospecimens for the development of robust RNA-based assays. Standardization of procedures and vigorous testing of alternative protocols are required to ensure that these assays function as designed.
Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation (2022)

Abstract Somatic activating mutations of PIK3CA are associated with the development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA -driven VMs consisting of human umbilical vein endothelial cells (HUVECs) expressing PIK3CA activating mutations embedded in 3D hydrogels. We observed enlarged and irregular vessel phenotypes, consistent with clinical signatures and concomitant with PI3K-driven upregulation of Rac1/PAK, MEK/ERK, and mTORC1/2 signaling. We observed differential effects between Alpelisib, a PIK3CA inhibitor, and Rapamycin, an mTORC1 inhibitor, in mitigating matrix degradation and vascular network topology. While both drugs are effective in preventing vessel enlargement, Alpelisib suppressed mTORC2-dependent AKT1 phosphorylation and MEK/ERK signaling. Rapamycin failed to reduce MEK/ERK and mTORC2 activity and resulted in vascular hyperbranching, while inhibiting PAK, MEK1/2, and mTORC1/2 signaling mitigates abnormal growth and vascular dilation. Collectively, these findings establish an in vitro platform for modeling VMs and confirm a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA -driven VMs.
A novel Injection Enhanced Floating Emitter (IEFE) IGBT structure improving the ruggedness against short-circuit and thermal destruction (2017)

In this work, we introduce a new collector IGBT structure that shows a huge improvement of the short-circuit (SC) ruggedness without deteriorating the static and dynamic losses of the device. The Injection Enhanced Floating Emitter (IEFE) concept enhances the emitter efficiency at the collector side by means of higher hole current injection which increases the bipolar current gain of the IGBT device. The simulation results indicate that the proposed structure can suppress a SC turn-off failure due to an electrical current crowding to a considerable extent. The critical pulse width to avoid thermal runaway of the leakage current after the SC event can be increased.
(Invited) Heterogeneous Integration of Ultra-Thin Sheets of Alternative Materials onto Silicon Substrates (2012)

Electric-field-assisted assembly is used to position ultra-thin, micron-sized sheets of alternative materials in high density arrays on silicon substrates. Dielectrophoretic forces induced on the solution-suspended polarizable sheets by a spatially varying, non-uniform electric field attract and align the sheets to lithographically defined assembly electrodes on the substrate. Studying the assembly of 10 µm long, 100 nm thick chromium sheets fabricated in three different widths of 1.2, 2.4, and 3.0 µm showed that the maximum array density decreases with increasing width. This result provides insight into the assembly of sheets composed of doped semiconductor device layers and junctions.