1666 5 AND 10 YEAR CANCER SPECIFIC RISK OF DEATH FROM SPORADIC TYPE I (LOW GRADE) PAPILLARY RCC: A SEER ANALYSIS (1973–2007) (2011)

You have accessJournal of UrologyKidney Cancer: Localized1 Apr 20111666 5 AND 10 YEAR CANCER SPECIFIC RISK OF DEATH FROM SPORADIC TYPE I (LOW GRADE) PAPILLARY RCC: A SEER ANALYSIS (1973–2007) Ryan N. Fogg, Marc C. Smaldone, Alexander Kutikov, Rosalia Viterbo, David Y.T. Chen, Richard E. Greenberg, and Robert G. Uzzo Ryan N. FoggRyan N. Fogg Philadelphia, PA More articles by this author , Marc C. SmaldoneMarc C. Smaldone Philadelphia, PA More articles by this author , Alexander KutikovAlexander Kutikov Philadelphia, PA More articles by this author , Rosalia ViterboRosalia Viterbo Philadelphia, PA More articles by this author , David Y.T. ChenDavid Y.T. Chen Philadelphia, PA More articles by this author , Richard E. GreenbergRichard E. Greenberg Philadelphia, PA More articles by this author , and Robert G. UzzoRobert G. Uzzo Philadelphia, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1799AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Hereditary papillary renal cell carcinoma (HPRCC) is associated with multifocal low grade papillary RCC and a low risk of death from metastatic disease. Using SEER data we investigated whether sporadic low grade (type 1) papillary renal cell carcinoma demonstrates similar long term low 5 and 10 year cancer specific mortality. METHODS All patients with clinically localized (Stage I/II), low grade (type 1) papillary RCC were identified in SEER (1973–2007). For comparison, similar cases of low stage, low grade clear cell RCC cases are also reported. Patient characteristics including age at diagnosis, race, gender, and tumor size were compared between low grade papillary and clear cell RCC using chi square tests and t-tests. Cancer specific mortality was analyzed using Gray's test and cumulative incidence functions. RESULTS 23,794 patients (mean age 59.7±13.0 years, 59.4% male) with clinically localized low grade papillary (n=1451, 6.1%) and clear cell (n=22,343, 93.9%) RCC were identified (mean tumor size 4.8±4.5cm). Comparing patients with papillary and clear cell RCC, groups differed with respect to age (p=0.01), sex (p<0.001), and race (p<0.001), but mean tumor size was similar. 5 year and 10 year CSS rates were 3.0% and 3.8% for stage I and II low grade papillary RCC versus 4.7% and 8.6% for low grade/stage clear cell RCC. Although overall mortality rates were comparable between groups, cancer specific mortality rates were significantly lower in the papillary RCC cohort (p=0.03). CONCLUSIONS Sporadic low grade papillary RCC is associated with very low 5 and 10 year CSS mortality rates (<4%). This data may be useful in counseling elderly patients or those with significant co-morbidities who demonstrate papillary RCC on needle biopsy and may be appropriate candidates for active surveillance programs. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e669 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ryan N. Fogg Philadelphia, PA More articles by this author Marc C. Smaldone Philadelphia, PA More articles by this author Alexander Kutikov Philadelphia, PA More articles by this author Rosalia Viterbo Philadelphia, PA More articles by this author David Y.T. Chen Philadelphia, PA More articles by this author Richard E. Greenberg Philadelphia, PA More articles by this author Robert G. Uzzo Philadelphia, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...