gebhart/patrepeval huggingface dataset:
Orientation controlled GaSb nanowires: from growth to application (2018)

In recent years, high-mobility GaSb nanowires have received tremendous attention for high-performance p-type transistors; however, due to the difficulty in achieving thin, uniform and orientation-controlled nanowires (NWs), there is limited report until now addressing their orientation-dependent properties in this important one-dimensional material system, where all these are essential information for the deployment of GaSb NWs in various applications. Using CMOS-compatible Pd catalysts, we demonstrated the formation of high-mobility 〈111〉 -oriented GaSb nanowires (NWs) via vapor-solid-solid (VSS) growth by the newly developed surfactant-assisted chemical vapor deposition through a complementary experimental and theoretical approach. In contrast to NWs formed by the conventional vapor-liquid-solid (VLS) mechanism, cylindrical-shaped Pd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> catalytic seeds were present in our Pd-catalyzed VSS-NWs. As solid catalysts, stoichiometric Pd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> was found to have the lowest crystal surface energy and thus giving rise to a minimal surface diffusion as well as an optimal in-plane interface orientation at the seed/NW interface for efficient epitaxial NW nucleation. Over 95% high crystalline quality NWs were grown in 〈111〉 orientation for a wide diameter range of between 10 and 70 nm. Back-gated field-effect transistors (FETs) fabricated using the Pd-catalyzed GaSb NWs exhibit a superior peak hole mobility of ~330 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , close to the mobility limit for a NW channel diameter of ~30 nm with a free carrier concentration of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . This suggests that the NWs have excellent homogeneity in phase purity, growth orientation, surface morphology and electrical characteristics. Contact printing process was also used to fabricate large-scale assembly of Pd-catalyzed GaSb NW parallel arrays, confirming the potential constructions and applications of these high-performance electronic devices.
Anin vivoexperimental model to determine antigenic variations among infectious bursal disease viruses (2013)

Infectious bursal disease virus (IBDV) is a double-stranded RNA virus causing infectious bursal disease in chickens. IBDV undergoes antigenic drift, so characterizing the antigenicity of IBDV plays an important role for identification and selection of vaccine candidates. In this study, an in vivo experimental model was developed to differentiate a new antigenic variant of IBDV. To this end, a hyper-immune serum to IBDV E/Del-type virus was generated in specific pathogen-free chickens and a standard volume of the hyper-immune serum was serially diluted and injected in specific pathogen-free birds via intravenous, subcutaneous, or intramuscular routes. The chickens were bled at different time points in order to evaluate the dynamics of virus neutralization titres. Based on the results, chickens were injected with different serum dilutions by the subcutaneous route. Twenty-four hours later, chickens were bled and then challenged with 100 median chicken infectious doses of the E/Del virus and a new IBDV variant. Chickens were euthanized at 7 days post infection and the bursa of Fabricius was removed for microscopic evaluation to determine the bursal lesion score. The determined virus neutralization titre along with the bursal lesion score was used to determine the breakthrough titre in the in vivo chicken model. Based on the data obtained, an antigenic subtype of IBDV was identified and determined to be different from E/Del. This model is a sensitive model for determination of IBDV antigenicity of non-tissue culture adapted IBDV.
Laser cooling of strontium atoms toward quantum degeneracy (2001)

We report on a narrow-line laser cooling and trapping of strontium atoms near quantum degeneracy. Employing a magneto-optical trap (MOT) on the spin-forbidden transition 1S0−3P1 at 689 nm, we have laser-cooled an atomic sample down to the photon recoil temperature of 400 nK with a phase space density of 10−2. The atoms were then compressed into a new type of far-off resonance optical dipole trap that was designed to allow simultaneous Doppler cooling, resulting in a phase space density of 10% to that required for quantum degeneracy. It is shown that this value is finally limited by light-assisted collisions occurring in the optical cooling. To reduce these inelastic losses, we applied evaporative cooling and demonstrated a creation of two-dimensional atomic gases.
On the stability region of multi-queue multi-server queueing systems with stationary channel distribution (2011)

In this paper, we characterize the stability region of multi-queue multi-server (MQMS) queueing systems with stationary channel and packet arrival processes. Toward this, the necessary and sufficient conditions for the stability of the system are derived under general arrival processes with finite first and second moments. We show that when the arrival processes are stationary, the stability region form is a polytope for which we explicitly find the coefficients of the linear inequalities which characterize the stability region polytope.
Dysregulated Host Responses Underlie 2009 Pandemic Influenza-Methicillin Resistant Staphylococcus aureus Coinfection Pathogenesis at the Alveolar-Capillary Barrier (2020)

Influenza viruses are a continual public health concern resulting in 3-5 million severe infections annually despite intense vaccination campaigns and messaging. Secondary bacterial infections, including <i>Staphylococcus aureus</i>, result in increased morbidity and mortality during seasonal epidemics and pandemics. While coinfections can result in deleterious pathologic consequences, including alveolar-capillary barrier disruption, the underlying mechanisms are poorly understood. We have characterized host- and pathogen-centric mechanisms contributing to influenza-bacterial coinfections in a primary cell coculture model of the alveolar-capillary barrier. Using 2009 pandemic influenza (pH1N1) and methicillin-resistant <i>S. aureus</i> (MRSA), we demonstrate that coinfection resulted in dysregulated barrier function. Preinfection with pH1N1 resulted in modulation of adhesion- and invasion-associated MRSA virulence factors during lag phase bacterial replication. Host response modulation in coinfected alveolar epithelial cells were primarily related to TLR- and inflammatory response-mediated cell signaling events. While less extensive in cocultured endothelial cells, coinfection resulted in changes to cellular stress response- and TLR-related signaling events. Analysis of cytokine expression suggested that cytokine secretion might play an important role in coinfection pathogenesis. Taken together, we demonstrate that coinfection pathogenesis is related to complex host- and pathogen-mediated events impacting both epithelial and endothelial cell regulation at the alveolar-capillary barrier.
Sequential Modeling with Multiple Attributes for Watchlist Recommendation in E-Commerce (2022)

In e-commerce, the watchlist enables users to track items over time and has emerged as a primary feature, playing an important role in users' shopping journey. Watchlist items typically have multiple attributes whose values may change over time (e.g., price, quantity). Since many users accumulate dozens of items on their watchlist, and since shopping intents change over time, recommending the top watchlist items in a given context can be valuable. In this work, we study the watchlist functionality in e-commerce and introduce a novel watchlist recommendation task. Our goal is to prioritize which watchlist items the user should pay attention to next by predicting the next items the user will click. We cast this task as a specialized sequential recommendation task and discuss its characteristics. Our proposed recommendation model, Trans2D, is built on top of the Transformer architecture, where we further suggest a novel extended attention mechanism (Attention2D) that allows to learn complex item-item, attribute-attribute and item-attribute patterns from sequential-data with multiple item attributes. Using a large-scale watchlist dataset from eBay, we evaluate our proposed model, where we demonstrate its superiority compared to multiple state-of-the-art baselines, many of which are adapted for this task.
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules (2018)

Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is a great need for robust methods for screening of relative FcRn-dependent recycling ability. Here, we report on a novel human endothelial cell-based recycling assay (HERA) that can be used for such pre-clinical screening. In HERA, rescue from degradation depends on FcRn, and engineered ligands are recycled in a manner that correlates with their half-lives in human FcRn transgenic mice. Thus, HERA is a novel cellular assay that can be used to predict how FcRn-binding proteins are rescued from intracellular degradation.
Search for Higgs-like bosons decaying into long-lived exotic particles (2016)

A search is presented for massive long-lived particles, in the 20-60 [Formula: see text] mass range with lifetimes between 5 and 100 [Formula: see text]. The dataset used corresponds to 0.62[Formula: see text] of proton-proton collision data collected by the LHCb detector at [Formula: see text]. The particles are assumed to be pair-produced by the decay of a Higgs-like boson with mass between 80 and 140 [Formula: see text]. No excess above the background expectation is observed and limits are set on the production cross-section as a function of the long-lived particle mass and lifetime and of the Higgs-like boson mass.
Lentivirus-Induced Dendritic Cells for Immunization Against High-Risk WT1 + Acute Myeloid Leukemia (2013)

Wilms' tumor 1 antigen (WT1) is overexpressed in acute myeloid leukemia (AML), a high-risk neoplasm warranting development of novel immunotherapeutic approaches. Unfortunately, clinical immunotherapeutic use of WT1 peptides against AML has been inconclusive. With the rationale of stimulating multiantigenic responses against WT1, we genetically programmed long-lasting dendritic cells capable of producing and processing endogenous WT1 epitopes. A tricistronic lentiviral vector co-expressing a truncated form of WT1 (lacking the DNA-binding domain), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-4 (IL-4) was used to transduce human monocytes ex vivo. Overnight transduction induced self-differentiation of monocytes into immunophenotypically stable "SmartDC/tWT1" (GM-CSF(+), IL-4(+), tWT1(+), IL-6(+), IL-8(+), TNF-α(+), MCP-1(+), HLA-DR(+), CD86(+), CCR2(+), CCR5(+)) that were viable for 3 weeks in vitro. SmartDC/tWT1 were produced with peripheral blood mononuclear cells (PBMC) obtained from an FLT3-ITD(+) AML patient and surplus material from a donor lymphocyte infusion (DLI) and used to expand CD8(+) T cells in vitro. Expanded cytotoxic T lymphocytes (CTLs) showed antigen-specific reactivity against WT1 and against WT1(+) leukemia cells. SmartDC/tWT1 injected s.c. into Nod.Rag1(-/-).IL2rγc(-/-) mice were viable in vivo for more than three weeks. Migration of human T cells (huCTLs) to the immunization site was demonstrated following adoptive transfer of huCTLs into mice immunized with SmartDC/tWT1. Furthermore, SmartDC/tWT1 immunization plus adoptive transfer of T cells reactive against WT1 into mice resulted in growth arrest of a WT1(+) tumor. Gene array analyses of SmartDC/tWT1 demonstrated upregulation of several genes related to innate immunity. Thus, SmartDC/tWT1 can be produced in a single day of ex vivo gene transfer, are highly viable in vivo, and have great potential for use as immunotherapy against malignant transformation overexpressing WT1.
Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes (2015)

We developed in situ single cell pull-down (SiCPull) of GFP-tagged protein complexes based on micropatterned functionalized surface architectures. Cells cultured on these supports are lysed by mild detergents and protein complexes captured to the surface are probed in situ by total internal reflection fluorescence microscopy. Using SiCPull, we quantitatively mapped the lifetimes of various signal transducer and activator of transcription complexes by monitoring dissociation from the surface and defined their stoichiometry on the single molecule level.
Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity (2014)

It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 12 anesthetized Sprague-Dawley rats, we controlled the pressure in isolated bilateral carotid sinuses (CSP), and measured splanchnic SNA and arterial pressure (AP). Under a constant CSP, increasing the voltage of AVNS dose dependently decreased SNA and AP. The averaged maximal inhibition of SNA was -28.0 ± 10.3%. To evaluate the dynamic impacts of AVNS on SNA, we performed random AVNS using binary white noise sequences, and identified the transfer function from AVNS to SNA and that from SNA to AP. We also identified transfer functions of the native baroreflex from CSP to SNA (neural arc) and from SNA to AP (peripheral arc). The transfer function from AVNS to SNA strikingly resembled the baroreflex neural arc and the transfer functions of SNA to AP were indistinguishable whether we perturbed ANVS or CSP, indicating that they likely share common central and peripheral neural mechanisms. To examine the impact of AVNS on baroreflex, we changed CSP stepwise and measured SNA and AP responses with or without AVNS. AVNS resets the sigmoidal neural arc downward, but did not affect the linear peripheral arc. In conclusion, AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native baroreflex.
Adaptation of Francisella tularensis to the Mammalian Environment Is Governed by Cues Which Can Be Mimicked In Vitro (2008)

The intracellular bacterium Francisella tularensis survives in mammals, arthropods, and freshwater amoeba. It was previously established that the conventional media used for in vitro propagation of this microbe do not yield bacteria that mimic those harvested from infected mammals; whether these in vitro-cultivated bacteria resemble arthropod- or amoeba-adapted Francisella is unknown. As a foundation for our goal of identifying F. tularensis outer membrane proteins which are expressed during mammalian infection, we first sought to identify in vitro cultivation conditions that induce the bacterium's infection-derived phenotype. We compared Francisella LVS grown in brain heart infusion broth (BHI; a standard microbiological medium rarely used in Francisella research) to that grown in Mueller-Hinton broth (MHB; the most widely used F. tularensis medium, used here as a negative control) and macrophages (a natural host cell, used here as a positive control). BHI- and macrophage-grown F. tularensis cells showed similar expression of MglA-dependent and MglA-independent proteins; expression of the MglA-dependent proteins was repressed by the supraphysiological levels of free amino acids present in MHB. We observed that during macrophage infection, protein expression by intracellular bacteria differed from that by extracellular bacteria; BHI-grown bacteria mirrored the latter, while MHB-grown bacteria resembled neither. Naïve macrophages responding to BHI- and macrophage-grown bacteria produced markedly lower levels of proinflammatory mediators than those in cells exposed to MHB-grown bacteria. In contrast to MHB-grown bacteria, BHI-grown bacteria showed minimal delay during intracellular replication. Cumulatively, our findings provide compelling evidence that growth in BHI yields bacteria which recapitulate the phenotype of Francisella organisms that have emerged from macrophages.
Novel Concepts for Integrating the Electric Drive and Auxiliary DC–DC Converter for Hybrid Vehicles (2008)

Cost, volume, and weight are three major driving forces in the automotive area. This is also true for hybrid electric vehicles, which are attracting more and more attention due to increasing fuel costs and air pollution. In hybrid vehicles, the energy distribution system causes a significant share of the volume and the costs. One part of this system is the DC-DC converter that transfers power between the low- and high-voltage buses. In order to reduce the costs and the volume of this converter, this paper presents a new concept for integrating the DC-DC converter functionality into the traction drive system. By using the inverter and the machine to implement a primary bridge leg of an isolated full-bridge DC-DC converter, the total system costs and weight can be reduced. This concept is verified by simulations and experimental results for a scaled prototype. An analytical model of the system has been developed and agrees very well with the measurements. By scaling this model to the power levels typical for hybrid vehicles, it is expected that the efficiency for the DC-DC converter will be greater than 85% for a conventional modulation scheme and above 91% for an optimized switching scheme.
Analysis of 5‐fluorouracil in saliva using surface‐enhanced Raman spectroscopy (2004)

Abstract The ability of surface‐enhanced Raman spectroscopy (SERS) to measure the chemotherapy drug 5‐fluorouracil in saliva is presented. A silver‐doped sol–gel provided SERS and also some chemical selectivity. 5‐Fluorouracil and physiological thiocyanate produced SERS, whereas large biochemicals, such as enzymes and proteins, did not, supporting the expectation that the larger molecules do not diffuse through the sol–gel to any appreciable extent. In addition, 5‐fluorouracil samples of 2 µg ml −1 were easily measured, and an estimated limit of detection of 150 ng ml −1 in 5 min should provide sufficient sensitivity to perform pharmacokinetic studies and to monitor and regulate patient dosage. This would fill a critical need for this highly used drug, since genetic‐based variations in its metabolism can range by as much as five‐fold from one patient to another. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Simultaneous Detection of Multiple Gases by Raman Spectroscopy with Hollow-Core Fibers (2014)

Raman spectroscopy of gas flowing through a hollow-core photonic crystal fiber HC -PCF) provides simultaneous detection of N2, O2, CO2, and CH4, with detection limits between 300 and 1000 ppm for 30 s of signal averaging.
Spectrum Efficient Support of IEEE 802.11ba in an IEEE 802.11ax Network (2019)

The IEEE 802.11ba Task Group is currently developing a standard for wake-up radios (WUR), intended to significantly reduce the total power consumption. In this paper, we study means to multiplex the signal intended for the WUR in the frequency domain with data transmitted according to the 802.11ax standard. Due to the different properties of the two signals, some care must be taken to ensure the inter-standard interference is kept sufficiently low. Two approaches to achieve this are proposed and evaluated. In the first, coexistence between the systems is ensured by using a guard interval, and in the second approach the signal used for the WUR is designed to be orthogonal to the 802.11ax signal. The latter is shown to give almost ideal performance for multiplexing the signals and could in principle be adopted without any need for a guard interval.
Utility investigation of artificial time delay in displacement-noise-free interferometers (2007)

Laser interferometer gravitational wave detectors are usually limited by displacement noise in their lower frequency band. Recently, theoretical proposals have been put forward to construct schemes of interferometry that are insusceptible to displacement noise as well as classical laser noise. These so-called displacement-noise-free interferometry (DFI) schemes take advantage of the difference between gravitational waves and displacement noise in their effects on light propagation. However, since this difference diminishes in lower frequencies (i.e., $\ensuremath{\Omega}&lt;c/{\mathcal{L}}_{D}$, with ${\mathcal{L}}_{D}$ the size of the detector), shot-noise-limited sensitivity of DFI schemes deteriorates dramatically in these frequencies---exactly the regime in which they are supposed to be superior, thereby limiting their applicability. In this paper, we explore the obvious possibility of increasing the effective size of the detector in the time domain, by introducing artificial time delays (${\mathcal{T}}_{D}\ensuremath{\gg}{\mathcal{L}}_{D}/c$) into the interferometry scheme, with the hope of improving low-frequency sensitivity. We found that sensitivity can only be improved by schemes in which fluctuations in the artificial time delays are not canceled.
Strut Allograft Union and Remodeling Using rhBMP-2 in a Spinal Corpectomy Model (2005)

Large cortical strut allografts (after lumbar corpectomy) supplemented with rhBMP-2 had incorporation and fusion strength comparable to allografts enhanced with cancellous autograft.
Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes (2020)

This paper describes the synthesis of a series of organic liquid crystals (LCs) containing selectively fluorinated cyclopropanes at their termini. The syntheses used difluorocarbene additions to olefin precursors, an approach which proved straightforward such that these liquid crystal candidates could be efficiently prepared. Their physical and thermodynamic properties were evaluated and depending on individual structures, they either displayed positive or negative dielectric anisotropy. The study gives some guidance into effective structure-property relationships for the design of LCs containing selectively fluorinated cyclopropane motifs.
Superconducting Nb3Ge for high-field magnets (1978)

Superconducting Nb3Ge tape conductors 5 to 10 m long were fabricated by chemical vapor deposition. Such tapes could be used in high-field magnet applications. Average tape properties set the upper performance limit of a magnet at 17 teslas (4.2 K). Highest critical-current densities obtained in thin and layered films set the upper performance limit at 20 teslas (4.2 K).