gebhart/patrepeval huggingface dataset:
The Influence of Linker Geometry in Bis(3‐hydroxy‐N‐methyl‐pyridin‐2‐one) Ligands on Solution Phase Uranyl Affinity (2011)

Abstract Seven water‐soluble, tetradentate bis(3‐hydroxy‐ N ‐methyl‐pyridin‐2‐one) (bis‐Me‐3,2‐HOPO) ligands were synthesized that vary only in linker geometry and rigidity. Solution‐phase thermodynamic measurements were conducted between pH 1.6 and pH 9.0 to determine the effects of these variations on proton and uranyl cation affinity. Proton affinity decreases by introduction of the solubilizing triethylene glycol group as compared to unsubstituted reference ligands. Uranyl affinity was found to follow no discernable trends with incremental geometric modification. The butyl‐linked 4 li‐Me‐3,2‐HOPO ligand exhibited the highest uranyl affinity, consistent with prior in vivo decorporation results. Of the rigidly‐linked ligands, the o ‐phenylene linker imparted the best uranyl affinity to the bis‐Me‐3,2‐HOPO ligand platform.
Multiuser capacity in block fading with no channel state information (2002)

Consider M independent users, each user having his own transmit antenna, that transmit simultaneously to a receiver equipped with N antennas through a Rayleigh block-fading channel having a coherence interval of T symbols, with no channel state information (CSI) available to either the transmitters or to the receiver. The total transmitted power is independent of the number of users. For a given coherence time T, we wish to identify the best multiaccess strategy that maximizes the total throughput. If perfect CSI were available to the receiver, it is known that the total capacity would increase monotonically with the number of users. If the CSI is available to both the receiver and to all transmitters, the throughput maximizing strategy implies for N=1 that only the single user who enjoys the best channel condition transmits. In the absence of CSI one is forced to a radically different conclusion. In particular, we show that if the propagation coefficients take on new independent values for every symbol (e.g., T=1) then the total capacity for any M > 1 users is equal to the capacity for M=1 user, in which case time division multiple access (TDMA) is an optimal scheme for handling multiple users. This result follows directly from a recent treatment of the single-user multiple antenna block-fading channel. Again, motivated by the single-user results, one is lead to the following conjecture for the multiple-user case: for any T > 1, the maximum total capacity can be achieved by no more than M = T users. The conjecture is supported by establishing the asymptotic result that, for a fixed N and a constant M/T for large T, the total capacity is maximized when M/T/spl rarr/0, which yields a total capacity per symbol of N log(1 + /spl rho/), where /spl rho/ is the expected signal-to-noise ratio (SNR) at the receiver. We further support the conjecture by examining the asymptotic behavior with large to for fixed M, T, and N /spl les/ T.
Follow‐up (2021)

The complexity of follow-up for cardiovascular implantable electronic devices (CIEDs: pacemakers, implantable cardioverter-defibrillators [ICDs], and cardiac resynchronization therapy [CRT]) parallels the increasing and evolving sophistication of the devices itself. CIEDs continue to acquire an increasing amount of data, both physiologic and device-related, to permit assessing health status, with the goal of notifying caregivers before clinical decompensation occurs to permit clinical intervention. Follow-up of patients with ICDs is in many respects similar to that of patients with pacemakers with a large emphasis on remote monitoring/remote interrogation. Indeed, with the progressive integration of pacemaker and ICD technology, assessing the “pacemaker” function of the ICD has become a standard part of ICD evaluation. Because of the specialized equipment necessary for pacemaker, ICD, and CRT assessment and follow-up, dedicated space is desirable.
Alterations in DNA methylation in human colon neoplasia (1987)

A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.
A neural tree architecture for recognition of speech features. (1991)

Neural tree networks provide an efficient technique for pattern classification. A typical structure grows the tree to accommodate the varying complexity of different problems. For recognition of speech features in continuous speech (as described by acoustic vectors), this architecture was found to grow unnecessarily when presented with large amounts of training material collected from many speakers. This paper describes a method for forward-pruning the tree through consideration of the degree of ‘‘confusion’’ among the applied patterns. This implementation was tested for recognition of 34 phonemes, extracted from the TIMIT database. Results show that in addition to advantages in computational efficiency and recognition performance, the neural tree architecture provides important correlations among the types of speech features being classified. One observation is that the parent network (first root) performs a separation between two classes of sounds; namely (a) vowels, glides, semivowels, and nasals, and (b) fricatives, affricates, and stop consonants. Subsequent networks are found to classify phonemes according to place of articulation (e.g., alveolar−/s/ and /z/), or manner of articulation (e.g., nasals−/m/, /n/, and /ng/). These phonemic classifications are valuable in improving the networks’ ability to perform feature recognition on data outside the training set.
Spectral Efficiency with One-Bit Transmitters under Out-of-Band Power Constraints (2022)

Low-resolution transceivers are being considered for millimeter-wave and higher frequency communications because of their simplicity and low power consumption. However, the non-linearities introduced by low-resolution digital-to-analog con- verters at the transmitters can cause significant out-of-band emissions since traditional bandwidth-limited pulse-shaping is not generally available. We model the performance of a low- resolution transmitter in terms of its spectral efficiency under out- of-band emission constraints. We show that the spectral efficiency can increase linearly with the symbol rate while satisfying out- of-band constraint. This implies that in order to achieve a given spectral efficiency under the bandwidth constraint, the symbol rate of the transmitter should be larger than a threshold. We derive an upper bound on this threshold.
Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease (2023)

Upadacitinib induction and maintenance treatment was superior to placebo in patients with moderate-to-severe Crohn's disease. (Funded by AbbVie; U-EXCEL, U-EXCEED, and U-ENDURE ClinicalTrials.gov numbers, NCT03345849, NCT03345836, and NCT03345823.).
Abstract 17409: Complex Electrical Substrates in Patients With High BMI and CHADSVASc Obscure Mapping of Rotational AF Drivers in Persistent AF (2016)

Introduction: Since traditional methods of mapping fail to reveal localized AF drivers, it is unexplained how ablation of limited areas guided by phase mapping can terminate persistent AF. We hypothesised that structural remodelling (LA size, raised BMI and high CHADSVASc) may reconcile traditional and phase mapping of AF. Methods: We recruited 60 patients at 5 international centers in whom persistent AF terminated by localized ablation (area Results: Each patient had AF termination (52% to sinus) by localized ablation, in whom we analyzed 550 activation (isochronal) maps. Unexpectedly, rotational sources were found by activation mapping, confirming phase maps in 15/60 (25%) cases (Figure A). Remaining cases had partial (45%) or no (30%) agreement (p 3 but not LA size or AF duration (table). Discussion: For the first time, this international study reveals rotational drivers of persistent AF by traditional mapping, focused at sites of known AF termination rather than arbitrary regions. However, traditional mapping was less sensitive than phase mapping for AF drivers, due to the impact of BMI and CHADSVASc substrates on electrograms. These data highlight the role of mapping technique in AF to guide ablation.
Objective Evaluation of Visual Fatigue Using Binocular Fusion Maintenance (2018)

BFM can be used to evaluate the visual fatigue caused by the new visual devices, such as head-mount display, objectively.
OC23.01: The prevalence of prenatal conditions detected by ultrasound in a rural clinic in Uganda (2013)

To observe the prevalence of prenatal conditions in a rural area of Uganda In June 2010, Imaging the World began offering access to basic antenatal ultrasound at Nawanyago Health Centre (HC III) in Uganda. This program, consisting of simple scanning protocols and internet based remote reading and reporting, provides reliable identification of several common prenatal conditions such as confirming intrauterine pregnancy, fetal number, fetal position, placental position, amniotic fluid volume and pelvic mass. Clinical records were collected prospectively after introduction of the ultrasound program in June of 2010 through March of 2012. During the study period, 1,084 women presented for evaluation at the HC III. Observations included: In patients with known age, the mean was 26 years old (range of 14 to 43 years) and 30% of the patients were 30 years or older; The timing of the visits to the HC III were 1st trimester at 7%, 33% during 2nd trimester at 33% and 3rd trimester at 54%; The fetal number was determined for 1,077 women (1 to 3 fetuses) with a multiple gestation rate of 3.9%; Fetal position was determined for 737 women with a malposition rate of 19.7%; Placental position was determined for 973 women with a malposition rate of 1.6%; Amniotic fluid volume was determined for 1,042 women with an abnormal volume rate of 2.7%; Screening for the presence of pelvic mass was performed in 598 women of whom 1.3% was observed to have a pelvic mass. The rate of pregnancy in women over 30 was higher than recent rates in the United States, (30% vs. 15%). The rate of multiple gestations was similar to the rate observed in the U.S., (3.3%). The rate of fetal malposition was substantially higher than that observed in the U.S., (19.7% vs. 5.5%). [Source: CDC National Vital Statistics Reports; Vol. 61, 5 and Vol. 61, 1]. This information may be used to inform decisions regarding prenatal health care management in low resource geographies.
Erratum: “Effect of dimensionality on the continuum percolation of overlapping hyperspheres and hypercubes. II. Simulation results and analyses” [J. Chem. Phys. 137, 074106 (2012)] (2014)

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Intermolecular Additions of Cyclobutanone Derived Radicals. A Convergent, Highly Efficient Access to Polycyclic Cyclobutane Containing Structures. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A perturbed hard-sphere-chain equation of state for nematic liquid crystals and their mixtures with polymers (1997)

A perturbed hard-sphere-chain (PHSC) equation of state is presented to compute nematic-isotropic equilibria for thermotropic liquid crystals, including mixtures. The equation of state consists of an isotropic term and an anisotropic term given by the Maier-Saupe theory whose contribution disappears in the isotropic phase. The isotropic contribution is the recently presented PHSC equation of state for normal fluids and polymers which uses a reference equation of state for athermal hard-sphere chains and a perturbation theory for the square-well fluid of variable well width. The PHSC equation of state gives excellent correlations of pure-component pressure-volume-temperature data in the isotropic region and, combined with the Maier-Saupe theory, correlates the dependence of nematic-isotropic transition temperature on the pressure. Theory also predicts a nematic-isotropic biphasic region and liquid-liquid phase separation in a temperature-composition diagram of binary mixtures containing a nematic liquid crystal and a normal fluid or polymer. Theory and experiment show good agreement for pure fluids as well as for mixtures.
Naturphilosophie (2020)

Naturphilosophie refers to a philosophical movement that began in Germany during the 1790s, characterised by a holistic, dynamic, and organic approach to the study of nature. The German term is conventionally left untranslated in English, for the most obvious rendering, ‘philosophy of nature’, fails to capture the ambitions evoked by the original. The proponents of Naturphilosophie, including Karl Friedrich Kielmeyer, Johann Wolfgang von Goethe, F.W.J. von Schelling, and G.W.F. Hegel, attempted to supplant previous modes of philosophy by advancing a holistic conception of nature in which matter, the celestial system, organic bodies, and the mind feature within a single, self-organising process. The core of Naturphilosophie can be defined by its distinctive metaphysical and epistemological commitments. In terms of metaphysics, its proponents were convinced that new research in magnetic, electrical, chemical, and biological phenomena could not be reduced to the mechanical interaction of particulate matter. They argued that natural science requires a new conception of nature in which the whole is prioritised over the parts. In terms of epistemology, proponents of Naturphilosophie argued that because nature is self-organising, it must be understood philosophically. This did not mean that empirical inquiry should be subordinate to philosophy but rather that experiments and observations should be interpreted speculatively, for the development of nature exhibits a rational structure. Naturphilosophie fell out of favour during the mid-nineteenth century with the rise of a mechanistic and materialist movement in natural science. Yet significant currents of Naturphilosophie persisted throughout the nineteenth and twentieth centuries, and several aspects remain pertinent in contemporary philosophy.
Ultralow-noise infrared focal plane array status (1998)

Low-noise pixel-based amplification via sub-micron CMOS is enabling advanced focal plane arrays offering ultra-low read noise for infrared astronomy, wave-front sensing, IR spectroscopy, spaceborne sensors and other discriminating uses. Specifically, we report the achievement of less than 30 e- read noise at video frame rates using capacitive transimpedance amplification and less than 1 e- using an enhanced form of gate modulation. We also compare several low- noise IR FPAs at various cutoff wavelengths from 1.1 micrometer to nearly 17 micrometer.
Flight Results from the GeneSat-1 Biological Microsatellite Mission (2007)

The mission of the GeneSat-1 technology demonstration spacecraft is to validate the use of research-quality instrumentation for in situ biological research and processing. To execute this mission, the GeneSat-1 satellite was launched on December 16, 2006 from Wallops Flight Facility as a secondary payload off of a Minotaur launch vehicle. During the first week of operation, the core biological growth test was successfully executed, and by the end of the first month of operation all primary science and engineering test objectives had been successfully performed. In its current phase of operation, a variety of secondary technology characterizations tests are being performed, and a wide range of educational, training, and public outreach programs are being supported. This paper reviews the GeneSat-1 mission system, discusses the government-industry-university teaming approach, and presents flight results pertaining to the primary scientific and engineering experiments.
AADL-Based Toolset for IMA System Design and Integration (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The paper presents an AADL-based toolset for Integrated Modular Avionics (IMA) design and integration. It describes activities of IMA system designer and system integrator that are supported by the toolset as well as its current architecture and future directions of development.&lt;/div&gt;&lt;/div&gt;
Human Tibial Cartilage Reveals Non-Linear and Non-Uniform Regional Topography Under Physiological Loading Rates (2012)

Nearly 3% of individuals worldwide experience pain, immobility, and compromised quality of life due to knee osteoarthritis (OA)1. It has been widely accepted that joint mechanics play a critical role in the initiation and progression of knee OA2. A shift away from the normal joint motion, for example due to injury or malalignment, is believed to produce an abnormal pattern of cartilage loading that creates unusual and damaging stresses within the tissue. Accurate knowledge of cartilage’s normal mechanical response to physiological loading—and particularly the regional dependence of this response—is critical to successfully testing this theory. To our knowledge, little is known about the regionally-dependent mechanical response of healthy human tibial cartilage under physiological loading conditions. There is also a compelling need for more accurate cartilage data to be integrated into computational simulations of the knee joint. Hence, the purpose of this study was two-fold: 1) to characterize the typical stress-strain response of tibial cartilage at 21 locations across the tibial plateau when subjected to loading representative of human walking, and 2) to demonstrate that these 21 sites can be reduced to a small number of regions displaying significantly different average moduli.
Concurrently Approaching Volumetric and Specific Capacity Limits of Lithium Battery Cathodes via Conformal Pickering Emulsion Graphene Coatings (2020)

Abstract To achieve the high energy densities demanded by emerging technologies, lithium battery electrodes need to approach the volumetric and specific capacity limits of their electrochemically active constituents, which requires minimization of the inactive components of the electrode. However, a reduction in the percentage of inactive conductive additives limits charge transport within the battery electrode, which results in compromised electrochemical performance. Here, an electrode design that achieves efficient electron and lithium‐ion transport kinetics at exceptionally low conductive additive levels and industrially relevant active material areal loadings is introduced. Using a scalable Pickering emulsion approach, Ni‐rich LiNi 0.8 Co 0.15 Al 0.05 O 2 (NCA) cathode powders are conformally coated using only 0.5 wt% of solution‐processed graphene, resulting in an electrical conductivity that is comparable to 5 wt% carbon black. Moreover, the conformal graphene coating mitigates degradation at the cathode surface, thus providing improved electrochemical cycle life. The morphology of the electrodes also facilitates rapid lithium‐ion transport kinetics, which provides superlative rate capability. Overall, this electrode design concurrently approaches theoretical volumetric and specific capacity limits without tradeoffs in cycle life, rate capability, or active material areal loading.
What Makes Kevin Spacey Look Like Kevin Spacey (2015)

We reconstruct a controllable model of a person from a large photo collection that captures his or her {\em persona}, i.e., physical appearance and behavior. The ability to operate on unstructured photo collections enables modeling a huge number of people, including celebrities and other well photographed people without requiring them to be scanned. Moreover, we show the ability to drive or {\em puppeteer} the captured person B using any other video of a different person A. In this scenario, B acts out the role of person A, but retains his/her own personality and character. Our system is based on a novel combination of 3D face reconstruction, tracking, alignment, and multi-texture modeling, applied to the puppeteering problem. We demonstrate convincing results on a large variety of celebrities derived from Internet imagery and video.
Wetenschappelijk verantwoorde casusbeschrijvingen vragen om methodische documentatie : De ontwikkeling van een documentatiemethode gebaseerd op de CARE-AAT-richtlijn (2018)

De maatschappelijke vraag naar onderbouwing van en evidentie voor vaktherapieën is aanleiding geweest om een documentatiemethode te ontwikkelen. De methode is gebaseerd op de CARE-AAT richtlijn voor publicatie van case reports en geoperationaliseerd met items afkomstig van&#13;\nberoepsbeoefenaren, opleiders en methodologen.&#13;\nDe documentatiemethode, bruikbaar voor de disciplines kunstzinnige therapie beeldend, muziek en spraak/drama, is door zeven therapeuten in de praktijk gebruikt. Hij wordt volledig bevonden maar leidde slechts in een geval tot een dossier dat zonder meer bruikbaar is voor het schrijven van een wetenschappelijke casusbeschrijving. De documentatiemethode is verder geëxpliciteerd op basis van de praktijkervaringen en zal in vervolgonderzoek verder ontwikkeld moeten worden.
Cyclic Adenosine 5'-Diphosphate Ribose-Mediated Cellular Signalling: New Insights using Synthetic Ligands (1999)

Using a chemoenzymatic approach we synthesized a number of structurally-modified analogues of the novel Ca2+-releasing cyclic nucleotide cADPR. This produced novel agonists, antagonists and enzyme inhibitors to investigate this new signalling pathway, and also the first membrane permeable antagonist.
The c-Jun/RHOB/AKT pathway confers resistance ofBRAF-mutant melanoma cells to MAPK inhibitors (2015)

The response of BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the molecular mechanisms driving these resistances are not completely understood. Here, we show that, in BRAF-mutant melanoma cells, inhibition of BRAF or its target MEK induces RHOB expression by a mechanism that depends on the transcription factor c-Jun. In those cells, RHOB deficiency causes hypersensitivity to BRAF and MEK inhibitors-induced apoptosis. Supporting these results, loss of RHOB expression in metastatic melanoma tissues is associated with an increased progression-free survival of BRAF-mutant patients treated with vemurafenib. Following BRAF inhibition, RHOB activates AKT whose inhibition causes hypersensitivity of BRAF-mutant melanoma cells to BRAF inhibitors. In mice, AKT inhibition synergizes with vemurafenib to block tumor growth of BRAF-mutant metastatic melanoma. Our findings reveal that BRAF inhibition activates a c-Jun/RHOB/AKT pathway that promotes tumor cell survival and further support a role of this pathway in the resistance of melanoma to vemurafenib. Our data also highlight the importance of using RHOB tumor levels as a biomarker to predict vemurafenib patient's response and to select those that would benefit of the combination with AKT inhibitors.
Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens (2005)

A study was conducted to determine the influence of sodium salicylate on the behaviour and the food and water consumption of broiler chickens after lipopolysaccharide (LPS) injection. An oral dose of 100 mg/kg sodium salicylate was given and an acute phase reaction in broiler chickens was provoked through the intravenous injection of Escherichia coli LPS. Water intake was higher in the LPS and salicylate-treated group than in the positive control group. The salicylate treatment, however, did not restore the food intake, or influence the behaviour of the chickens. These data show that sodium salicylate has a positive effect on the water intake after intravenous injection of LPS in chickens and suggests that there is a difference in mechanism of action of food and water consumption after LPS injection in chickens.