gebhart/patrepeval huggingface dataset:
Supplementary Figure from Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors (2023)

Supplementary Figure from Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors
Mask effects for high-NA EUV: impact of NA, chief-ray-angle, and reduction ratio (2013)

With higher NA (≫ 0.33) and increased chief-ray-angles, mask effects will significantly impact the overall scanner performance. We discuss these effects in detail, paying particular attention to the multilayer-absorber interaction, and show that there is a trade-off between image quality and reticle efficiency. We show that these mask effects for high NA can be solved by employing a reduction ratio &lt;4X, and show several options for a high-NA optics. Carefully discussing the feasibility of these options is an important part of defining a high-NA EUV tool.
Supplementary Figure 2 from <i>miR-152</i> Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer (2023)

&lt;p&gt;PDF file - 261K&lt;/p&gt;
MMSE denoising of sparse L&#x00E9;vy processes via message passing (2012)

Many recent algorithms for sparse signal recovery can be interpreted as maximum-a-posteriori (MAP) estimators relying on some specific priors. From this Bayesian perspective, state-of-the-art methods based on discrete-gradient regularizers, such as total-variation (TV) minimization, implicitly assume the signals to be sampled instances of Lévy processes with independent Laplace-distributed increments. By extending the concept to more general Lévy processes, we propose an efficient minimum-mean-squared error (MMSE) estimation method based on message-passing algorithms on factor graphs. The resulting algorithm can be used to benchmark the performance of the existing or design new algorithms for the recovery of sparse signals.
The Evolution of Insulin and How it Informs Therapy and Treatment Choices (2020)

Insulin has been available for the treatment of diabetes for almost a century, and the variety of insulin choices today represents many years of discovery and innovation. Insulin has gone from poorly defined extracts of animal pancreata to pure and precisely controlled formulations that can be prescribed and administered with high accuracy and predictability of action. Modifications of the insulin formulation and of the insulin molecule itself have made it possible to approximate the natural endogenous insulin response. Insulin and insulin formulations had to be designed to produce either a constant low basal level of insulin or the spikes of insulin released in response to meals. We discuss how the biochemical properties of endogenous insulin were exploited to either shorten or extend the time-action profiles of injectable insulins by varying the pharmacokinetics (time for appearance of insulin in the blood after injection) and pharmacodynamics (time-dependent changes in blood sugar after injection). This has resulted in rapid-acting, short-acting, intermediate-acting, and long-acting insulins, as well as mixtures and concentrated formulations. An understanding of how various insulins and formulations were designed to solve the challenges of insulin replacement will assist clinicians in meeting the needs of their individual patients.
Peering Into the Peer Review Process and Acknowledging Those Who Do It Well (2019)

Nerrolyn Ramstrand, on behalf of the Editors-in-Chief, Prosthetics and Orthotics International. Email: [email protected]
All your face are belong to us (2012)

Two-factor authentication is widely used by high-value services to prevent adversaries from compromising accounts using stolen credentials. Facebook has recently released a two-factor authentication mechanism, referred to as Social Authentication, which requires users to identify some of their friends in randomly selected photos. A recent study has provided a formal analysis of social authentication weaknesses against attackers inside the victim's social circles. In this paper, we extend the threat model and study the attack surface of social authentication in practice, and show how any attacker can obtain the information needed to solve the challenges presented by Facebook. We implement a proof-of-concept system that utilizes widely available face recognition software and cloud services, and evaluate it using real public data collected from Facebook. Under the assumptions of Facebook's threat model, our results show that an attacker can obtain access to (sensitive) information for at least 42% of a user's friends that Facebook uses to generate social authentication challenges. By relying solely on publicly accessible information, a casual attacker can solve 22% of the social authentication tests in an automated fashion, and gain a significant advantage for an additional 56% of the tests, as opposed to just guessing. Additionally, we simulate the scenario of a determined attacker placing himself inside the victim's social circle by employing dummy accounts. In this case, the accuracy of our attack greatly increases and reaches 100% when 120 faces per friend are accessible by the attacker, even though it is very accurate with as little as 10 faces.
Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network (2016)

About a third of PCNSL patients are primary refractory to first line treatment. We identified several independent prognostic factors that can guide the management of R/R PCNSL patients.
Levels and chemical composition of PM in a city near a large Cu-smelter in Spain (2011)

A long-term series (2001-2008) of chemical analysis of atmospheric particulate matter (PM(10) and PM(2.5)) collected in the city of Huelva (SW Spain) is considered in this study. The impact of emission plumes from one of the largest Cu-smelters in the world on air quality in the city of Huelva is evidenced by the high daily and hourly levels of As, other potentially toxic elements (e.g. Cu, Zn, Cd, Se, Bi, and Pb) in particulate matter, as well as the high levels of some gaseous pollutants (NO(2) and SO(2)). Mean arsenic levels in the PM10 fraction were higher than the target value set by European Directive 2004/107/EC (6 ngAs m(-3)) for 1(st) January 2013. Hourly peak concentrations of As and other metals and elements (Zn, Cu, P and Se) analyzed by PIXE can reach maximum hourly levels as high as 326 ngAs m(-3), 506 ngZn m(-3), 345 ngCu m(-3), 778 ngP m(-3) and 12 ngSe m(-3). The contribution of Cu-smelter emissions to ambient PM is quantified on an annual basis in 2.0-6.7 µg m(-3) and 1.8-4.2 µg m(-3) for PM(10) and PM(2.5), respectively. High resolution outputs of the HYSPLIT dispersion model show the geographical distribution of the As ambient levels into the emission plume, suggesting that the working regime of the Cu-smelter factory and the sea breeze circulation are the main factors controlling the impact of the Cu-smelter on the air quality of the city. The results of this work improve our understanding of the behaviour of industrial emission plumes and their impact on air quality of a city, where the population might be exposed to very high ambient concentrations of toxic metals during a few hours.
An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control (1990)

A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-2 (MAP2), is thought to be an early intermediate in an insulin-stimulated phosphorylation cascade and in a variety of other mammalian cell responses to extracellular signals. A complementary DNA that encodes this protein serine-threonine kinase has been cloned, and the protein designated extracellular signal-regulated kinase 1 (ERK1). ERK1 has striking similarity to two protein kinases, KSS1 and FUS3, from yeast. The yeast kinases function in an antagonistic manner to regulate the cell cycle in response to mating factors. Thus, ERK1 and the two yeast kinases constitute a family of evolutionarily conserved enzymes involved in regulating the response of eukaryotic cells to extracellular signals.
Targeting liver stage malaria with metformin (2019)

Despite an unprecedented 2 decades of success, the combat against malaria - the mosquito-transmitted disease caused by Plasmodium parasites - is no longer progressing. Efforts toward eradication are threatened by the lack of an effective vaccine and a rise in antiparasite drug resistance. Alternative approaches are urgently needed. Repurposing of available, approved drugs with distinct modes of action are being considered as viable and immediate adjuncts to standard antimicrobial treatment. Such strategies may be well suited to the obligatory and clinically silent first phase of Plasmodium infection, where massive parasite replication occurs within hepatocytes in the liver. Here, we report that the widely used antidiabetic drug, metformin, impairs parasite liver stage development of both rodent-infecting Plasmodium berghei and human-infecting P. falciparum parasites. Prophylactic treatment with metformin curtails parasite intracellular growth in vitro. An additional effect was observed in mice with a decrease in the numbers of infected hepatocytes. Moreover, metformin provided in combination with conventional liver- or blood-acting antimalarial drugs further reduced the total burden of P. berghei infection and substantially lessened disease severity in mice. Together, our findings indicate that repurposing of metformin in a prophylactic regimen could be considered for malaria chemoprevention.
P‐43: Application of High Stiffness Glass Substrate for Multi‐Functional Large Area Displays (2020)

Demand of large size flat panel displays are emerging. For upcoming displays, extra features are demanded in addition to the visual performance. One of the attracting features is the combination with an acoustic function. To utilize the display panel as a speaker, glass substrate plays important role to improve its acoustic quality. In this study, the effect of elastic property on display panel performance was investigated.
Analysis method for ERD in mu-rhythm detection in motor imagery brain-computer interface (2016)

Motor imagery brain-computer interfaces (MIBCI) use hand or foot MI to control computers. However, MIBCI control accuracy is low. Previously, we determined that using max power in the mu band method, i.e., the peak trace method (PTM), improves event-related desynchronization (ERD) detection accuracy. Control accuracy may be improved by improving ERD detection accuracy in an MIBCI. In this study, we compare the PTM to the band power method to determine the most effective method for ERD detection during MI tasks. Overall, experimental results indicate that we could not detect ERD more accurately using the PTM. However, the PTM may be effective depending on the mu rhythm occurrence pattern.
Extended Venous Thromboembolism Prophylaxis after Radical Cystectomy: A Call for Adherence to Current Guidelines (2017)

Patients undergoing radical cystectomy are at high risk for venous thromboembolism after hospital discharge. There is strong evidence that extended prophylaxis significantly decreases the risk of venous thromboembolism in oncologic surgery cases. Use of extended prophylaxis after radical cystectomy has been poorly adopted, emphasizing the need for better adherence to current urology procedure specific guidelines as extended prophylaxis for radical cystectomy is the standard of care. Specific and rare circumstances may require case by case assessment.
ChemInform Abstract: α‐Amino Aldehyde Equivalents as Substrates for Rabbit Muscle Aldolase: Synthesis of 1,4‐Dideoxy‐1,4‐imino‐D‐arabinitol and 2(R),5(R) ‐Bis(hydroxymethyl)‐3(R),4(R)‐dihydroxypyrrolidine. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Review on Pressure Ulcer: Aetiology, Cost, Detection and Prevention Systems (2014)

Pressure ulcer (also known as pressure sore, bedsore, ischemia, decubitus ulcer) is a global challenge for today’s healthcare society. Found in several locations in the human body such as the sacrum, heel, back of the head, shoulder, knee caps, it occurs when soft tissues are under continuous loading and a subject’s mobility is restricted (bedbound/chair bound). Blood flow in soft tissues becomes insufficient leading to tissue necrosis (cell death) and pressure ulcer. The subject’s physiological parameters (age, body mass index) and types of body support surface materials (mattress) are also factors in the formation of pressure ulcer. The economic impacts of these are huge, and the subject’s quality of life is reduced in many ways. There are several methods of detecting and preventing ulceration in human body. Detection depends on assessing local pressure on tissue and prevention on scales of risk used to assess a subject prior to admission. There are also various types of mattresses (air cushioned/liquid filled/foam) available to prevent ulceration. But, despite this work, pressure ulcers remain common.This article reviews the aetiology, cost, detection and prevention of these ulcers.
Butanol Blending - a Promising Approach to Enhance the Thermodynamic Potential of Gasoline - Part 1 (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Blending gasoline with oxygenates like ethanol, MTBE or ETBE has a proven potential to increase the thermodynamic efficiency by enhancing knock resistance.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The present research focuses on assessing the capability of a 2- and tert-butanol mixture as a possible alternative to state-of-the-art oxygenates. The butanol mixture was blended into a non-oxygenated reference gasoline with a research octane number (RON) of 97. The butanol blending ratios were 15% and 30% by mass. Both the thermodynamic potential and the impact on emissions were investigated.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Tests are performed on a highly boosted single-cylinder gasoline engine with high load capability and a direct injecting fuel system using a solenoid-actuated multi-hole injector. The engine is equipped with both intake and exhaust cam phasers. The engine has been chosen for the fuel investigation, as it represents the SI technology with a strongly increasing market share.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The blended gasoline-butanol mixtures showed a distinct increase in RON and MON numbers as well as in heat of vaporization. As a consequence, high and full load efficiency could be improved by earlier ignition timing and hence a more favorable center of combustion could be attained. The indicated mean effective pressure (IMEP) could be increased by more than 20% in comparison to the reference gasoline at an equivalent level of coefficient of variance (COV) of IMEP. The gain in knock resistance could contribute to a significant reduction in CO₂ emissions when compression ratio is increased or when engine downsizing is realized. At low and medium loads, identical or slightly improved performance regarding thermodynamics and emissions could be detected.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;With the ongoing discussion on the limitation of particulate emission from gasoline engines, the observed capability of butanol blends to reduce soot particle mass and number especially at cold engine conditions can be regarded as a positive impact of the butanol blends when compared to the non-oxygenated gasoline.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This study underlines the high potential of the investigated 2- and tert-butanol mixtures to serve as oxygenates for blending into gasoline in order to achieve higher fuel quality levels. Furthermore, detailed investigations including multi-cylinder engine experiments are planned for part 2.&lt;/div&gt;&lt;/div&gt;
Wet fingerprint recognition: Challenges and opportunities (2011)

Many fingers wrinkle or shrivel when immersed in water. When used for biometric identification, the recognition rate for wrinkled fingers degrades. The impact of wrinkling has so far not been well-understood. In this study, we present an investigation of how the finger-skin expansion due to wrinkling impacts the quality of scanned finger prints and characterize the qualitative changes that affect recognition. We also introduce the Wet and Wrinkled Finger (WWF) database that we will make available to other researchers. In this database of 300 fingers, 185 are visibly wrinkled after immersion; multiple images of dry and immersed fingerprints were acquired. In this paper, we present baseline recognition rates on WWF using two algorithms a commercial fingerprint recognition algorithm and the publicly available Bozorth3 matcher. Specifically, we show a degradation in accuracy with both algorithms when comparing Dry-finger to Dry finger verification with Dry-finger to Wet-finger verification. We analyze performance on a per-finger basis and note a difference in accuracy amongst fingers, and as consequence make recommendations about which fingers to use in environments where fingers are apt to be wet. Additionally, we propose an implementation of a classifier that can decide if the incoming query is wrinkled.
Fabrication of Freeform Optics in Ultra-Precision Raster Milling (2007)

Recently, the high quality and high productivity in fabrication of freeform optics has been of primary interest in manufacturing industries, such as die and mould manufacturing, aerospace part manufacturing, and so forth. However, the fabrication of freeform optics is currently expensive and vastly complex. Ultra-precision raster milling can produce non-rotational symmetric surfaces with sub-micrometric form accuracy and nanometric surface finish without the need for any subsequent post polishing. While, there is little research work focus on this kind of machining method. This paper presents a framework of a tool path generation system for freeform surface ultra-precision raster milling. This system includes model of freeform optics, tool path generator, interference monitor and an optimization model of machining parameters. The tool path generation system can generate interference free and optimal tool path for machining freeform surfaces. Some simulation results have been presented to illustrate the performance of the system.
Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity (2020)

Alzheimer's disease is the most common neurodegenerative disorder. Finding a pharmacological approach that cures and/or prevents the onset of this devastating disease represents an important challenge for researchers. According to the amyloid cascade hypothesis, increases in extracellular amyloid-β (Aβ) levels give rise to different aggregated species, such as protofibrils, fibrils and oligomers, with oligomers being the more toxic species for cells. Many efforts have recently been focused on multi-target ligands to address the multiple events that occur concurrently with toxic aggregation at the onset of the disease. Moreover, investigating the effect of endogenous compounds or a combination thereof is a promising approach to prevent the side effects of entirely synthetic drugs. In this work, we report the synthesis, structural characterization and Aβ antiaggregant ability of new derivatives of hyaluronic acid (Hy, 200 and 700 kDa) functionalized with carnosine (Car), a multi-functional natural dipeptide. The bioactive substances (HyCar) inhibit the formation of amyloid-type aggregates of Aβ<sub>42</sub> more than the parent compounds; this effect is proportional to Car loading. Furthermore, the HyCar derivatives are able to dissolve the amyloid fibrils and to reduce Aβ-induced toxicity in vitro. The enzymatic degradation of Aβ is also affected by the interaction with HyCar.
Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics (2018)

NCT02427555.
How far will silicon nanocrystals push the scaling limits of NVMs technologies? (2004)

For the first time, memory devices with optimized high density (2E12#/cm/sup 2/) LPCVD Si nanocrystals have been reproducibly achieved and studied on an extensive statistical basis (from single cell up to 1 Mb test-array) under different programming conditions. An original experimental and theoretical analysis of the threshold voltage shift distribution shows that Si nanocrystals have serious potential to push the scaling of NOR and NAND flash at least to the 35 nm and 65 nm nodes, respectively.
Locating relevant text within XML documents (2008)

Traditional document retrieval has shown to be a competitive approach in XML element retrieval, which is counter-intuitive since the element retrieval task requests all and only relevant document parts to be retrieved. This paper conducts a comparative analysis of document and element retrieval, highlights the relative strengths and weaknesses of both approaches, and explains the relative effectiveness of document retrieval approaches at element retrieval tasks.
ChemInform Abstract: Selective Inversion of the Proximal or Distal Hydroxyl Groups in syn, syn‐3‐(N‐(Alkoxycarbonyl)amino) 1,2‐Diols via Cyclic Sulfates. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Detection of an ultrabright submillimetre galaxy in the Subaru/XMM-Newton Deep Field using AzTEC/ASTE (2011)

We report on the detection of an extremely bright (37 mJy at 1100 m and 91 mJy at 880 m) submillimetre galaxy (SMG), AzTEC-ASTE-SXDF1100.001 (hereafter referred to as SXDF1100.001 or Orochi), discovered in the 1100 m observations of the Subaru/XMM-Newton Deep Field using AzTEC on ASTE. Subsequent CARMA 1300-m and SMA 880m observations successfully pinpoint the location of Orochi and suggest that it has two components, one extended [full width at half-maximum (FWHM) of 4 arcsec] and one compact (unresolved). Z-Spec on CSO has also been used to obtain a wide-band spectrum from 190 to 308 GHz, although no significant emission/absorption lines were found. The derived upper limit to the line-to-continuum flux ratio is 0.1-0.3 (2 ) across the Z-Spec band.
Copy Number Variations in Schizophrenia: Critical Review and New Perspectives on Concepts of Genetics and Disease (2010)

The more penetrant CNVs have direct implications for clinical practice and diagnostic subtyping. CNVs with lower penetrance promise to contribute to our genetic understanding of pathogenesis. The findings provide insight into a broader neuropsychiatric spectrum for schizophrenia than previously conceived and indicate new directions for genetic studies.
Olefin Epoxidation by Methyltrioxorhenium: A Density Functional Study on Energetics and Mechanisms (1998)

A spiro attack on a peroxo group is calculated to be the preferred reaction pathway for olefin epoxidation with the catalytic system CH3ReO3/H2O2 (see picture). This finding is supported by density functional calculations on more than ten transition states for the most probable mechanisms. Hydration has significant effects on various reaction species: it stabilizes the intermediates and destabilizes, with one exception, the transition states.
I-2 injection stimulated dislocation motion in semiconductors (1975)

Summary form only. An abstract of the above-titled article taken from the Device Research Conference (24-26 June 1975, Carleton University, Ottawa, Ont., Canada) is presented.