gebhart/patrepeval huggingface dataset:
Patients using antifungals following laryngectomy: a qualitative study of community pharmacists in the North of England (2013)

This study highlights that community pharmacists lack understanding in relation to laryngectomy and are unaware of the off-label doses and administration methods of the drugs (specifically nystatin) used to prevent fungal colonisation on voice prostheses. Additional information sources in the form of an educational leaflet, possibly obtained through the local department of speech and language therapy, would be perceived as a valuable resource to support community pharmacists who are required to manage these patients in the community.
Supplementary Data from Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer (2023)

&lt;p&gt;Supplemental figures 1-6&lt;/p&gt;
Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis (2009)

The intestinal mucus barrier of patients with UC is significantly altered concerning its phospholipid concentration and species composition. These alterations may be very important for the pathogenesis of this disease and underline new therapeutic strategies.
Textureless object detection using cumulative orientation feature (2015)

We propose a novel image feature for textureless object detection. The feature is based on quantized gradient orientations those have been shown to be robust to cluttered backgrounds and illumination changes. We make this feature robust to the appearance changes of a targeted object itself induced by its transformations and small deformations. In our proposed method, we add small random values to the similarity transformation parameters and synthesize many model images. Then quantized orientations are extracted on these images and the orientations are cumulated at each pixel. The frequencies of selected features are utilized as weights when calculating scores. Our proposed feature is evaluated on publicly available dataset and achieve top-class performance both in speed and detection accuracy compared to state-of-the-art techniques.
Synthesis of Nano‐sized BaTiO 3 Powders by the Rotary‐Hydrothermal Process (2008)

Nano‐sized BaTiO 3 powders with narrow size distribution and high tetragonality were attempted to be synthesized by the rotary‐hydrothermal process in a water system as a novel technique, using a mixture of anatase‐type TiO 2 and Ba(OH) 2 as starting material. The rotary‐hydrothermal syntheses were performed under conditions with a rotary‐speed of 20 revolutions per minute at 423–523 K for 3–96 h. Highly‐ and mono‐dispersed BaTiO 3 powders mainly composed of coarse‐faceted particles with the tetragonal phase were successfully synthesized by controlling the conditions for rotary‐hydrothermal treatments. TEM and TG results revealed that these coarse‐faceted BaTiO 3 particles contained very few structural defects such as hydroxyl content. Thus, the rotary‐hydrothermal process was a useful method to synthesize very high‐quality BaTiO 3 particles, and the further control of various conditions of the rotary‐hydrothermal treatment is expected to control the crystalline phase and microstructures of final BaTiO 3 powders.
Human Vascular Smooth Muscle Cell–Monocyte Interactions and Metalloproteinase Secretion in Culture (1995)

Degradation of the atherosclerotic plaque extracellular matrix could destabilize the lesion, rendering it more prone to rupture. Both macrophages and vascular smooth muscle cells (SMCs) are potential sources of matrix metalloproteinases (MMPs), secreted enzymes that can digest vascular matrix. We explored interactions between human vascular SMCs and human monocytes that result in the secretion of interstitial collagenase (MMP-1) and stromelysin (MMP-3). Monocytes alone or those treated with SMC-conditioned media did not secrete these metalloproteinases as detectable by Western blot analysis. SMCs increased secretion of both MMP-1 and MMP-3 greater than 20-fold when cocultured with monocytes or when treated with monocyte-conditioned media. Addition of macrophage colony stimulating factor (< or = 1000 U/mL) to cocultures of monocytes and SMCs did not affect metalloproteinase secretion. Recombinant interleukin (IL)-1 receptor antagonist inhibited MMP-1 and MMP-3 induction in SMC cultures treated with monocyte-conditioned media (94% and 96% reduction, respectively), while a neutralizing antibody to tumor necrosis factor-alpha had no significant effect on metalloproteinase secretion. In contrast to the induction by monocyte-conditioned media of MMP-1 and MMP-3 secretion by SMCs, monocyte-conditioned media did not increase secretion of 72-kD gelatinase (MMP-2). Thus, monocytes induce MMP-1 and MMP-3 secretion by vascular SMCs through an IL-1-dependent mechanism. This response of SMCs to a defined macrophage product may contribute to plaque destabilization by mononuclear phagocytes in the lesion.
Vacuum Retrofits: The Process, Benefits, and Risks (1997)

Older circuit breakers have had an excellent reliability for the period of time intended. These circuit breakers have performed satisfactorily for at least 10 to 15 years, and most, 20 to 30 years, with a certain level of preventive maintenance performed. Unfortunately, normal age, deterioration, and wear have brought: many of these circuit breakers to the end of their useful life, from a reliability and maintainability standpoint. We address reliability and maintainability of the existing circuit breakers, as well as the improvements gained by the vacuum retrofit process. Retrofit design factors, which affect reliability and maintainability of the final product, are also addressed; as well as alternatives and cost considerations, applications, specification recommendations, and associated switchgear improvements. The gains achieved in equipment life extension are self evident. A detailed review is also provided concerning the safety interlocks, which must be properly incorporated into a retrofit.
Vertical Silicon-on-Insulator Coupler for High Density Optical Interconnects (2023)

We present an ultra-compact dual-polarization coupler working at normal incidence to the chip surface for use with multi-core fibers with a core-to-core spacing down to 15 µm. The coupler achieves an unprecedented efficiency of − 3 . 8 dB for a device with a footprint of only 100 µm 2 and a 3-dB bandwidth of 59 nm.
Interim Analysis of Phase 2 Results for Cemiplimab in Patients with Metastatic Basal Cell Carcinoma (mBCC) who Progressed on or are Intolerant to Hedgehog Inhibitors (HHIs) (2021)

Abstract not available.
Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies (2015)

Resting-state functional connectivity is a promising biomarker for Alzheimer's disease. However, previous resting-state functional magnetic resonance imaging studies in Alzheimer's disease and amnestic mild cognitive impairment (aMCI) have shown limited reproducibility as they have had small sample sizes and substantial variation in study protocol. We sought to identify functional brain networks and connections that could consistently discriminate normal aging from aMCI despite variations in scanner manufacturer, imaging protocol, and diagnostic procedure. We therefore combined four datasets collected independently, including 112 healthy controls and 143 patients with aMCI. We systematically tested multiple brain connections for associations with aMCI using a weighted average routinely used in meta-analyses. The largest effects involved the superior medial frontal cortex (including the anterior cingulate), dorsomedial prefrontal cortex, striatum, and middle temporal lobe. Compared with controls, patients with aMCI exhibited significantly decreased connectivity between default mode network nodes and between regions of the cortico-striatal-thalamic loop. Despite the heterogeneity of methods among the four datasets, we identified common aMCI-related connectivity changes with small to medium effect sizes and sample size estimates recommending a minimum of 140 to upwards of 600 total subjects to achieve adequate statistical power in the context of a multisite study with 5-10 scanning sites and about 10 subjects per group and per site. If our findings can be replicated and associated with other established biomarkers of Alzheimer's disease (e.g., amyloid and tau quantification), then these functional connections may be promising candidate biomarkers for Alzheimer's disease.
Self-assembled organic thin films on electroplated copper for prevention of corrosion (2004)

Self-assembled organic thin films of dodecanethiol (DT), mercaptobenzothiazole (MBT), benzotriazole (BTA), imidazole (IMD) and benzothiazole (BT) are formed by adsorption on the surface of copper thin film used in ultralarge-scale integrated circuits. The films are characterized by x-ray photoelectron spectroscopy. The inhibition of corrosion of these organic thin films is investigated in aerated 0.5 M H2SO4 solutions by electrochemical impedance spectroscopy and potentiodynamic polarization techniques. The presence of these films reduced corrosion by blocking the copper surface from the oxygen dissolved in the acid medium. The relative inhibition efficiencies of these inhibiting agents in preventing copper oxidation are found to be in the order of DT&amp;gt;MBT&amp;gt;BT&amp;gt;BTA&amp;gt;IMD. The effectiveness of the inhibitors increased with the temperature, concentration of the inhibitors, and duration of immersion in the solution. An adsorption model is proposed on the basis of variation of the impedance according to the inhibitor concentration. The stability and packing of the inhibitors on the surface appear to be the most important factors in determining the inhibitive efficiency of the inhibitors.
Optical transduction of chemical sensing by thin films of colour reagents and molecular receptors using piezo-optical and surface plasmon resonance methods (2000)

Two novel chemical sensing systems using thin organic films have been elaborated and compared, one involving well established colour reagents used with a novel piezo-optical transduction system and the other using alkylviologen films for molecular recognition of phenols, with transduction via surface plasmon resonance (SPR) techniques. In the piezo-optical technique, chopped light absorbed by the thin sensing film deposited on piezoelectric polyvinylidene fluoride (PVDF) is converted into heat by non-radiative decay. This expands the film, stressing the PVDF and generating an electric charge which is measured using a lock-in amplifier. The signal dependence on optical absorption length, thermal diffusion length, film uniformity and porosity, chopper frequency and amplifier phase synchronisation are reviewed. The design and selection of molecular receptors for phenols, and the fabrication of thin films suitable for SPR, are described together with results demonstrating response patterns to different phenols and products of atmospheric aging of phenol solutions. The relative advantages of these two very different generic transduction techniques for organic thin film sensing layers are discussed with reference to the data presented on the selected sensing systems.
Long Wavelength External Cavity Quantum Cascade Laser for Spectroscopic Application (2018)

We present a long wavelength external cavity quantum cascade laser. The fabrication of the external cavity laser is described including anti-reflection coating design, simulations, and results. Spectroscopic feasibility is proven by measurement of ammonia absorption.
Effect of amorphous crosslinker on phase behavior of polymer stabilized blue phase liquid crystals (2022)

Blue phase liquid crystals (BPLCs) composed of double twisted cholesteric helixes are promising materials for use in next generation displays, optical components, and photonics applications. However, BPLCs are only observed in a narrow temperature range of 0.5-3 oC and must be stabilized with a polymer network. Here we report on controlling the phase behavior of BPLCs by varying the concentration of an amorphous crosslinker (PETA). LC mixtures without PETA display narrow temperature phase transitions from isotropic to BP-II, BP-I, and cholesteric phases, but the addition of PETA widens temperature window up to 10C. Above 3wt% PETA prevents the formation of BP-II and the mixture instead transitions from isotropic directly to BP-I phase. Blue phase I or II are stabilized using polymer networks via in-situ photopolymerization. Bandwidth broadening and red tuning responses are observed in polymer stabilized BPLCs with 10wt% and 15wt% polymer concentrations when DC voltage is applied.
Sex Differences in 1-Year Rehospitalization for Heart Failure and Myocardial Infarction After Primary Percutaneous Coronary Intervention (2019)

It is unclear whether universal access to primary percutaneous coronary intervention (pPCI) may reduce sex differences in 1-year rehospitalization for heart failure (HF) and myocardial infarction (MI) after ST-elevation myocardial infarction (STEMI). We studied 7,597 consecutive STEMI patients (13.8% women, n = 1,045) who underwent pPCI from January 2007 to December 2013. Cox regression models adjusted for competing risk from death were used to assess sex differences in rehospitalization for HF and MI within 1 year from discharge. Compared with men, women were older (median age 67.6 vs 56.0 years, p &lt; 0.001) with higher prevalence of co-morbidities and multivessel disease. Women had longer median door-to-balloon time (76 vs 66 minutes, p &lt; 0.001) and were less likely to receive drug-eluting stents (19.5% vs 24.1%, p = 0.001). Of the medications prescribed at discharge, fewer women received aspirin (95.8% vs 97.6%, p = 0.002) and P2Y12 antagonists (97.6% vs 98.5%, p = 0.039), but there were no significant sex differences in other discharge medications. After adjusting for differences in baseline characteristics and treatment, sex differences in risk of rehospitalization for HF attenuated (hazard ratio [HR] 1.05, 95% confidence interval [CI] 0.79 to 1.40), but persisted for MI (HR 1.68, 95% CI 1.22 to 2.33), with greater disparity in patients aged ≥60 years (HR 1.83, 95% CI 1.18 to 2.85) than those aged &lt;60 years (HR 1.45, 95% CI 0.84 to 2.50). In conclusion, in a setting of universal access to pPCI, the adjusted risk of 1-year rehospitalization for HF was similar in both sexes, but women had significantly higher adjusted risk of 1-year rehospitalization for MI, especially older women.
Supplemental Tables S1-S11 from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks (2023)

&lt;p&gt;Table S1. Clinical data for patient-derived PDX1, PDX2, UPPP1, and UPPP2 samples used for ChIP-based analysis. Table S2. ChIP-DNA qRT-PCR primers-probe sequence Table S3. Sample-specific enrichment of H3K4me3 histone mark at 5''UTR of individual genes. Table S4. Sample-specific enrichment of H3K27ac histone mark at 5''UTR of individual genes. Table S5. Sample-specific enrichment of H3K9ac histone mark at 5''UTR of individual genes. Table S6. Sample-specific enrichment of H3K9me3 histone mark at 5''UTR of individual genes. Table S7. Gene set enrichment analysis of genes linked to H3K27ac-enrichment specific for tumor samples. Table S8. Gene set enrichment analysis of genes linked to H3K27ac-enrichment specific for normal samples. Table S9. Gene set enrichment analysis of genes linked to H3K4me3-enrichment specific for tumor samples. Table S10. Gene set enrichment analysis of genes linked to H3K4me3-enrichment specific for normal samples. Table S11. Correlation of H3K27ac-enriched with genes differentially regulated in HPV-KRT and HPV-IMU.&lt;/p&gt;
Modeling and control of robotic surgical platform for single-port access surgery (2014)

In this paper, we present a modeling and control method for a single-port access robot developed by our robotics group at the Samsung Advanced Institute of Technology. The surgical robot consists of a snake-like 6-degree-of-freedom (DOF) guide tube, two 7-DOF tools, a 3-DOF stereo camera, and a 5-DOF slave arm. The robot is capable of reaching various surgical sites inside the abdominal cavity from a single incision on the body. To estimate the workspace and control the guide tube to a desired location, we first obtain the forward kinematics model of the guide tube and then propose a Cartesian-level controller. The wire actuation mechanism for the tools exhibit nonlinear backlash behavior because of wire compliance and friction between the wire and Teflon-coated conduit. We compensate for the backlash in the tool joints by adding the backlash inverse with smoothing term as a feedforward term.
Saturable absorption of a double layer graphene modulator on a slot waveguide (2022)

The saturable absorption of a double-layer graphene modulator is experimentally demonstrated on a silicon slot waveguide platform. Saturation was found to start at ~0.8W with a maximum saturation depth of 1.9 dB for a $50 \mu \mathrm{m}$ long graphene modulator.
Bioactivation of water-soluble peptidic quantum dot through biotin-streptavidin binding (2008)

This paper describes the preparation of bioactive water-soluble fluorescent CdSe/ZnS semi-conductor quantum dots with a small hydrodynamic diameter of 10 nm. These quantum dots are functionalized with a biotinylated peptide that can be introduced at different ratios onto the surface of the quantum dots. Their ability to bind to streptavidin in solution is tested by using gel electrophoresis and fluorescence resonance energy transfer with a fluorescent labeled-streptavidin. The binding of these quantum dots to Agarose micrometric beads coated with streptavidin is also analyzed by fluorescent optical microscopy. A synthetic pegylated peptide is successfully used to prevent the non specific adsorption of streptavidin onto the quantum dots. A specific binding to the streptavidin results in the formation of a very stable streptavidin-quantum dot complex without any significant aggregation. The average number of streptavidin per quantum dot is found to be to 4 at the most. Such bioactivate quantum dots can be further conjugated to any biotinylated biomolecule and used in biological medium.
Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia (1996)

Chromanols, which were recently shown to inhibit cAMP-mediated Cl- secretion in colon crypts via a blockade of a cAMP-activated K+ conductance, were analyzed for their effects on distinct cloned K+ channels expressed in Xenopus oocytes. The lead chromanol 293B specifically inhibited I(sK) channels with an IC50 of 7 micromol/l without affecting the delayed rectifier Kv1.1 or the inward rectifier Kir2.1. Moreover, several other chromanols displayed the same rank order of potency for I(sK) inhibition as demonstrated in colon crypts. Finally, we tested the effects of the previously described I(sK) blocker azimilide on cAMP mediated Cl- secretion in rat colon crypts. Similar to 293B azimilide inhibited the forskolin induced Cl- secretion. These data suggest that I(sK) protein induced K+ conductances are the targets for the chromanol 293B and its analogues, and azimilide.
HLA AND NON‐INSULIN DEPENDENT DIABETES IN FIJI INDIANS (1981)

HLA frequency distributions in Fiji Indians with non-insulin dependent diabetes were compared with those in control subjects with confirmed two-hour plasma glucose levels less than 7.8 mmol/L. Antigen frequencies at HLA-A and HLA-DR loci were similar in patients and controls. At HLA-B, there was a significant increase in Bw61 (Bw40.2) in diabetics, with a relative risk for this antigen of 4.8. Since a similar finding has been reported previously in South African Indians with Insulin-dependent diabetes, it is possible that wer have defined yet another genetically-distinct form of diabetes, especially prevalent in Indians. Alternatively, definition of new HLA alleles such as Bw61, a new subdivision of an established antigen, may reveal HLA associations with non-insulin dependent diabetes in European Caucasians also.
Supplementary Figure 3 from Enhanced Effector Responses in Activated CD8<sup>+</sup> T Cells Deficient in Diacylglycerol Kinases (2023)

&lt;p&gt;PDF file - 73K, Similar expression of Granzyme B and perforin in dgk-deficient mesoCAR T cells&lt;/p&gt;
Parabolic pulses from Yb:fiber amplifiers: a new paradigm for high power ultrashort pulse generation (2000)

We report parabolic pulse generation from a high gain Yb:doped fiber amplifier. After self-similar propagation in standard optical fiber and subsequent pulse compression, 70 fs pulses with 80 kW peak power are generated.
Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates (1992)

Chimeric receptors composed of the human epidermal growth factor receptor (EGF-R) extracellular domain fused to wild-type and truncated platelet-derived growth factor receptor (PDGF-R) intracellular sequences were stably expressed in NIH 3T3 cells devoid of endogenous EGF-Rs. This experimental system allowed us to investigate the biological activity of PDGF-R cytoplasmic-domain mutants in PDGF-R-responsive NIH 3T3 cells by activating PDGF-specific signaling pathways with EGF. Deletion of 74 carboxy-terminal amino acids severely impaired the ability of the PDGF-R cytoplasmic domain to associate with cellular substrates in vitro. This deletion also inhibited receptor and substrate phosphorylation, reduced the receptor's mitogenic activity, and completely abolished its oncogenic signaling potential. Surprisingly, removal of only six additional amino acids, including Tyr-989, restored substantial receptor and substrate phosphorylation capacity as well as transforming potential and yielded a receptor with wild-type levels of ligand-induced mitogenic activity. However, the ability of this chimera to bind phospholipase C gamma was severely impaired in comparison with the ability of the wild-type receptor, while the association with other cellular proteins was not affected. Further deletion of 35 residues, including Tyr-977, nearly abolished all PDGF-R cytoplasmic-domain biological signaling activities. None of the three C-terminal truncations completely abolished the mitogenic potential of the receptors or had any influence on ligand binding or receptor down regulation. Together, these data implicate the 80 C-terminal-most residues of the PDGF-R, and possibly Tyr-989, in phospholipase C gamma binding, while receptor sequences upstream from Asp-988 appear to be essential for specific interactions with other cellular polypeptides such as ras GTPase-activating protein and phosphatidylinositol 3-kinase. Thus, the mutants described here allow the separation of distinct PDGF-activated signaling pathways and demonstrate that phospholipase C gamma phosphorylation is not required for mitogenesis and transformation.
Impact of transient response of instrument transformers on phasor measurements (2010)

The instrument transformer is the necessary equipment which connects the primary power system and PMU. Therefore, the measurement accuracy of PMU is directly affected by the transfer accuracy and the transient response of instrument transformer. In this paper, the dynamic signal models are abstracted from the phenomena of practical power systems. Under such kinds of dynamic signal models, the impact of instrument transformer on PMU is analyzed in detail, especially for the saturation problem of the current transformer and the ferromagnetic resonance and transient response of capacitor voltage transformer. Based on the analysis, the suggestions for the evaluation criteria of PMU dynamic behavior can be provided. Moreover, the principles of choosing instrument transformers in the wide-area measurement systems are suggested as well.