gebhart/patrepeval huggingface dataset:
PDK1, the missing link in insulin signal transduction (2000)

Conference Abstract| October 01 2000 PDK1, the missing link in insulin signal transduction Philip Cohen; Philip Cohen 1MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Michayla Williams; Michayla Williams 1MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Dario R. Alessi Dario R. Alessi 1MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 2000 Biochemical Society2000 Biochem Soc Trans (2000) 28 (5): A142. https://doi.org/10.1042/bst028a142a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Philip Cohen, Michayla Williams, Dario R. Alessi; PDK1, the missing link in insulin signal transduction. Biochem Soc Trans 1 October 2000; 28 (5): A142. doi: https://doi.org/10.1042/bst028a142a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Ventricular tachycardia secondary to abandoned epicardial pacemaker lead (2015)

Late complications from pacemaker leads are infrequent. The majority of lead-related issues, such as dislodgment and perforation, occur around the time of implant.1 Rarely, arrhythmias are triggered by the physical presence of the lead. We present the case of a patient with recurrent ventricular tachycardia (VT) precipitated by positional change and specific movements, and associated with a pacing lead placed 3 decades earlier.
The Use of Porous Palladium(II)‐polyimine in Cooperatively‐ catalyzed Highly Enantioselective Cascade Transformations (2015)

Abstract Porous organic polymers have prospects as functional substrates for catalysis, with quite different molecular properties from inorganic substrates. Here we disclose for the first time that porous palladium(II)‐polyimines are excellent catalysts for cooperatively catalyzed and enantioselective cascade reactions. In synergy with a chiral amine co‐catalyst, polysubstituted cyclopentenes and spirocyclic oxindoles, including the all‐carbon quaternary stereocenter, were synthesized in high yields. High diastereo‐ and enantioselectivities were achieved for these dynamic kinetic asymmetric transformations (DYKAT) of enals with propargylic nucleophiles. magnified image
Photonic crystal slab sensor with enhanced surface area (2010)

In this work, we demonstrate improved molecular detection sensitivity for silicon slab photonic crystal cavities by introducing multiple-hole defects (MHDs), which increase the surface area available for label-free detection without degrading the quality factor. Compared to photonic crystals with L3 defects, adding MHDs into photonic crystal cavities enabled a 44% increase in detection sensitivity towards small refractive index perturbations due to surface monolayer attachment of a small aminosilane molecule. Also, photonic crystals with MHDs exhibited 18% higher detection sensitivity for bulk refractive index changes.
Immersion scanners enabling 10nm half-pitch production and beyond (2014)

Nikon’s new immersion scanner “NSR-S630D” has been developed to deliver enhanced product overlay and CD uniformity while improving productivity at 10 nm half pitch node and beyond. The NSR-S630D is equipped with various advanced technologies. Among them are the new reticle stage with encoder servo control and advanced reticle bending mechanism, new optics with enhanced correction knobs for thermal aberration control, and advanced thermally stable wafer stage; all of which are key components to providing the best scanner solution to meet the requirements for 10 nm half pitch node and beyond. In this paper, we describe the NSR-630D development concept and the latest performance data at factory. One of the key factors in improving overlay is shot distortion; in order to improve shot distortion, the NSR-S630D is equipped with a newly developed state-of-the-art projection lens. The overall overlay improvements have been made possible not only by minimizing lens distortion through advancements in lens manufacturing techniques, but also by reducing thermal distortion, which is especially important in actual device production. In addition, we have also added a new function for more effective reticle heating distortion compensation. In order to improve wafer grid performance, we newly designed a wafer table with enhanced thermal stability. We have also further improved the reticle bending system in order to minimize the field curvature induced by projection lens thermal aberration. The new features described above, in addition to the matured Streamlign platform, have enabled the NSR-S630D to deliver highest accuracy and stability.
A compact substrate spreading resistance model for SoC (2004)

Mixed signal SoC ICs are increasingly being used in commercial products. However, the analog circuits are sensitive to noise which is produced by the digital circuits and propagated by the substrate. In this paper, compact physical 2D and 3D models have been derived for the spreading resistance between multiple contacts within two different substrates. These models can be used to estimate substrate noise.
Watermarking deep neural networks for embedded systems (2018)

Deep neural networks (DNNs) have become an important tool for bringing intelligence to mobile and embedded devices. The increasingly wide deployment, sharing and potential commercialization of DNN models create a compelling need for intellectual property (IP) protection. Recently, DNN watermarking emerges as a plausible IP protection method. Enabling DNN watermarking on embedded devices in a practical setting requires a black-box approach. Existing DNN watermarking frameworks either fail to meet the black-box requirement or are susceptible to several forms of attacks. We propose a watermarking framework by incorporating the author&#x0027;s signature in the process of training DNNs. While functioning normally in regular cases, the resulting watermarked DNN behaves in a different, predefined pattern when given any signed inputs, thus proving the authorship. We demonstrate an example implementation of the framework on popular image classification datasets and show that strong watermarks can be embedded in the models.
Timing of Adverse Prostate Cancer Reclassification on First Surveillance Biopsy: Results from the Canary Prostate Cancer Active Surveillance Study (2016)

Timing of the first active surveillance biopsy was not associated with increased adverse reclassification but prostate specific antigen density and body mass index were. In low risk patients on active surveillance, it may be reasonable to perform the first active surveillance biopsy at a later time, reducing the overall cost and morbidity of active surveillance.
Evidence From the Scientific Assessment of Electronic Cigarettes and Their Role in Tobacco Harm Reduction (2021)

Summary While smoking remains a main global cause of preventable morbidity and mortality, a potential inflection point has arrived where it could become possible for non-combustible nicotine products to displace cigarettes and reduce risk for smokers who transition completely from smoking. These have proven consumer satisfaction and are now widely and increasingly available globally. One of the most prominent of these nicotine products are electronic cigarettes (ECs), which are used daily by millions of current and former smokers. The category is not without controversy as these products are not risk free and can cause nicotine dependence. The differing interpretation of science assessing ECs has transpired into inconsistent regulation and product standards, providing an environment for its fragmented manufacturing base which allows for variable product quality and in turn, product quality variability has impacted on how they are viewed. In this review, we assess published scientific evidence to evaluate whether, on balance, ECs fulfil a tobacco harm reduction role by reducing health risks relative to smoking and providing a viable alternative for smokers while having limited appeal to non-smokers.
ChemInform Abstract: A New Synthesis of 1‐Chloroalkynes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Thermochromic Dibismuthines with Nonthermochromic Distibine Analogues. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P207-T Protein Identification and Quantitative Analysis of Complex Mixtures Using a Peptide-Based Isobaric Mass Tagging Technology (2007)

A major goal in proteomics is to accurately measure changes in the relative abundance of large sets of proteins in complex biological systems. Isobaric mass tagging with ExacTag labels is a powerful platform for simultaneously analyzing relative protein levels from multiple complex samples. The technology provides a superior approach, combining high precision and reproducibility to accurately determine the relative expression level of individual proteins in a complex mixture. A bioinformatics approach has been developed to enable fast and accurate protein identification and quantification through analyzing ExacTag-labeled peptides from MS/MS spectra. This approach combines popular protein identification programs such as Mascot or Sequest with an internally developed quantification software package. The results of the protein identification are used to predict labeled peptides, including possible posttranslational modifications, which can be used for quantification. In parallel, each spectrum in the MS/MS data is scanned for ions coming from the mass tag labels. The package then searches the quantification results, matching the precursor mass to predicted peptides, and generates a list of quantified peptides for each protein. This study focuses on accurately assessing the quantitative consistency of the labeling technology, without introducing the confounding issue of biological variability. Complex samples were prepared consisting of different defined ratios of human serum and Escherichia coli bacterial cellular lysate. The protein mixtures were then labeled with different cysteine-reactive tags in order to compare protein expression levels among the different samples all at once using tandem mass spectrometry. The measured differences in protein levels correlated well with the known input ratios of the two complex samples, reproducing changes in abundance of over 20-fold range. The described technology provides a powerful method for enhancing proteomic analysis by mass spectrometry.
Electrochemical and Kinetic Studies of Li[sub 1.156]Mn[sub 1.844]O[sub 4] (2006)

The electrochemical and kinetic properties of a lithium-rich spinel material, , were investigated to illustrate the impact of the excessive lithium on the performance of spinel-based lithium-ion cells. It was found that the capacity retention of such mesocarbon microbead/spinel cells was significantly deteriorated when the upper cutoff voltage was raised from 4.1 to at . The significant difference on the capacity retention was attributed to the irreversible reaction at about , which was further related to the electrochemical reaction of lithium-rich spinel at high voltages. The low rate cycling of Li/spinel cells at different temperatures showed the evolution of at least three irreversible peaks above . Moreover, the Li/spinel cells showed continuous impedance growth after extraction of the excessive lithium. The kinetic study showed that the irreversible peaks shifted toward low potential as the temperature increased. It is predicted that the first irreversible peak shows up at about vs at . It suggests that the upper cutoff voltage of such graphite/spinel cells should be limited to at . The kinetic study also indicates that such graphite/spinel cells can be cycled up to at without triggering any detrimental impact.
EFFECT OF SUB-CLINICAL HYPOTHYROIDISM ON CHOLESTEROL AND TRIGLYCERIDES (2018)

Background: Sub-clinical Hypothyroidism (SCH) is associated with dyslipidemias which may increase the cardiovascular risk. The objective of this study was to compare the serum levels of cholesterol and triglycerides in subclinical hypothyroidism and normal euthyroid subjects. Methods: This cross-sectional comparative study had control group of 50 euthyroid subjects selected from Mayo Hospital, Lahore who were advised to get thyroid profile checked. Fifty sub-clinical hypothyroid patients were included on the basis of their thyroid profile reports. Fasting blood samples were taken from both the groups for analysis of serum levels of T4, total cholesterol and Triglycerides. Studentâ€™s t-test was used to compare the mean values, and pâ‰¤0.05 was considered statistically significant. Results: Mean Triglyceride level in SCH was 168.28 mg/dl, and in euthyroid controls it was 133.62 mg/dL (p<0.001). There were no differences of total cholesterol in both groups with value of 190 mg/dL in SCH group and 189.12 in control group (p=0.912). Triglycerides level was raised in SCH and there was no pronounced effect on total cholesterol. Conclusion: The effects of SCH are more pronounced on triglycerides and less on total cholesterol.
Reply (2004)

that these increases reflect disease in infants not yet fully immunized and waning vaccine-induced immunity in adolescents and adults. Second, there is no evidence that genotypic variation affects protection against pertussis vaccines; vaccine-efficacy estimates have not decreased in countries with high coverage (e.g., the United Kingdom, France, Finland, and the United States), despite the genetic diversity of B. pertussis strains.
Electron Beam Lithography of HSQ and PMMA Resists and Importance of their Properties to Link the Nano World to the Micro World (2010)

In this work we investigated the properties of HSQ and PMMA resists focusing on contrast and line width for ebeam lithography (EBL) application. HSQ was found to be a good candidate to have desired line widths but the contrast we obtained was less than it was for PMMA. Since the fluorine based plasma does not have high selectivity over exposed HSQ, we propose a PMMA/HSQ bi-layer resist stack as a hard mask to etch Si selectively. Using this technique, 50nm deep Si fins may be patterned.
The snowdrop lectin Galanthus nivalis agglutinin (GNA) and a fusion protein ButaIT/GNA have a differential affect on a pest noctuid Lacanobia oleracea and the ectoparasitoid Eulophus pennicornis (2010)

Fusion proteins have considerable potential as novel insect control agents because they enable the oral delivery of insecticidal peptides to the haemolymph of pests. Transport is achieved via fusion of the toxin to a carrier protein Galanthus nivalis agglutinin (GNA) that, after ingestion, binds to and crosses the insect gut epithelia. A fusion protein comprising a toxin from the South Indian red scorpion ( Mesobuthus tamulus ) that is fused to a GNA polypeptide (ButaIT/GNA) has a detrimental effect on the development of tomato moth Lacanobia oleracea (L.) (Lepidoptera: Noctuidae) larvae. The present study examines the effects of ButaIT/GNA and GNA, delivered orally or by injection, on the development of L. oleracea larvae, and the subsequent effects on the gregarious ectoparasitoid Eulophus pennicornis (Nees) (Hymenoptera: Eulophidae) developing on ButaIT/GNA‐ and GNA‐treated hosts. The fusion protein, but not GNA, reduces the growth of fifth stadium L. oleracea larvae. The development of E. pennicornis is not affected by the presence of ButaIT/GNA in hosts that ingest the protein, although it is affected when hosts are injected with the protein. This difference is considered to be a result of higher levels of fusion protein being present when the fusion protein is injected. Intact ButaIT/GNA is detected by immunoassay in the haemolymph of L. oleracea larvae after ingestion of the fusion protein. More unexpectedly, negative effects are observed for the growth of E. pennicornis larvae developing on hosts that have either ingested, or been injected with GNA.
Magnetic Resonance Imaging of Articular Cartilage (2001)

Magnetic resonance imaging is the optimal modality for assessing articular cartilage because of superior soft tissue contrast, direct visualization of articular cartilage, and multiplanar capability. Despite these advantages, there has been disagreement as to the efficacy of magnetic resonance imaging of articular cartilage. The reason for this controversy is multifactorial but in part is attributable to the lack of the use of optimized pulse sequences for articular cartilage. The current authors will review the current state of the art of magnetic resonance imaging of articular cartilage and cartilage repair procedures, discuss future new directions in imaging strategies and methods being developed to measure cartilage thickness and volume measurements, and propose a magnetic resonance imaging protocol to evaluate cartilage that is achievable on most magnetic resonance scanners, vendor independent, practical (time and cost efficient), and accepted and used by a majority of musculoskeletal radiologists.
LSD-induced hallucinogen persisting perception disorder treatment with clonidine: an open pilot study (2000)

A pilot open study was conducted in order to evaluate the efficacy of clonidine in the treatment of LSD-induced hallucinogen persisting perception disorder (HPPD). Eight patients fulfilled entrance criteria. All complained of HPPD for at least 3 months and were drug free at least 3 months. They received fixed low doses of clonidine, 0.025 mg, three times a day for 2 months. They were evaluated by the Clinical Global Impression Scale (CGI) and a self-report scale on the severity of symptoms (graded 0-5). Patients scored an average of 5.25 (SD = 0.46) on the CGI and 4 on the self-report scale at baseline, indicating marked psychopathology. One patient dropped out at week 3 and a second patient dropped out at week 5. Of the six patients remaining at the end of 2 months, the average CGI score was 2.5 (SD = 0.55) and the self-report scale score was 2, indicating mild symptomatology. LSD-related flashbacks associated with excessive sympathetic nervous activity may be alleviated with clonidine in some patients.
Spanner's concurrency control (2013)

The Spanner project reports that one can build practical large-scale systems that combine strong semantics with geo-distribution. In this review manuscript, we provide insight on how Spanner's concurrency control provides both read-only transactions which avoid locking data, and strong consistency.
Multiple Myeloma–Associated Ig Light Chain Crystalline Cast Nephropathy (2020)

Renal involvement is a common complication in multiple myeloma (MM), a malignant neoplasm arising from an abnormal proliferation of clonal plasma cells in the bone marrow.1 MM-associated renal disorders such as amyloidosis and cast nephropathy usually result from the extracellular deposition of monoclonal Ig free light chains (FLCs). Monoclonal Ig FLCs excreted in the urine are referred to as Bence–Jones proteins (BJPs).2
In situ FIB-SEM Experimentation: from Nanoscale Wetting to Nanofabrication of Gallium-based Liquid Metals (2014)

Stretchable conductors are of interest for a number of applications including soft robotics, flexible electronics, and biomedical devices. [1] The use of liquid metals is particularly attractive because, in contrast to semiconductor based stretchable electronics, [1] circuitry based on these materials is intrinsically soft and remains functional even when stretched to several times its initial length. The first example of liquid-phase electronics is the Whitney strain gauge, Recently, mercury has been replaced with safer room-temperature liquid eutectic gallium alloys such as gallium-indium-tin (Galinstan). Besides polymer encapsulated strain sensors, Because of the wide-range of potential applications, new routes of patterning liquid-metal structures aiming to replace the current manual syringe injection-molding process have been proposed. Examples of these methods include vacuum-induced patterning, However, fabrication of well-defined patterns with feature sizes below 50 has not yet been achieved. The primary reasons limiting spatial resolution of these novel fabrication techniques are complex wetting dynamics and strong adhesion of gallium-based liquid metals to majority of materials resulting from rapid oxidation of the metal surface (e.g., formation of "oxide-sack" in Fig.
High Frequency Optically Coherent Analog Antenna Link with True Time Delay (2005)

There has been much interest in the use of high bandwidth, light weight optical fiber to implement true time delays in future generations of phased array 4qeq4[1-2]. Among the various architectures proposed, the coherent detection architecture[2] offers several important advantages including high channel packing density, excellent SNR and the flexibility needed in large - scale phased array radar antenna systems. This type of system is very compact, transmitting several hundred delays to different antenna elements using a single fiber.
Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait (2017)

Dcc plays a role in the development of local spinal networks to ensure proper lateralization of motor control during locomotion. Local spinal cord defects following loss of Dcc cause a hopping gait in mice and may contribute to MM in humans. Developmental Dynamics 247:620-629, 2018. © 2017 Wiley Periodicals, Inc.
Aluminum nitride integrated photonics platform for the ultraviolet to visible spectrum (2018)

We demonstrate a wide-bandgap semiconductor photonics platform based on nanocrystalline aluminum nitride (AlN) on sapphire. This photonics platform guides light at low loss from the ultraviolet (UV) to the visible spectrum. We measure ring resonators with intrinsic quality factor (Q) exceeding 170,000 at 638 nm and Q >20,000 down to 369.5 nm, which shows a promising path for low-loss integrated photonics in UV and visible spectrum. This platform opens up new possibilities in integrated quantum optics with trapped ions or atom-like color centers in solids, as well as classical applications including nonlinear optics and on-chip UV-spectroscopy.
The BESIII drift chamber (2007)

To meet with requirements of BESIII experiment, the main tracking device is a cylindrical drift chamber with small-cell geometry, using a helium-based gas and operating in a 1T magnetic field. A cosmic ray test without magnetic field has been carried out. Preliminary results show that the rms of the residual distribution is 168μm after the pre-alignment and the calibration of T0 and time-to-distance relation.