gebhart/patrepeval huggingface dataset:
LAUNCHING A SCIENCE CAREER (2008)

RETURN TO ISSUEPREVBook ReviewNEXTLAUNCHING A SCIENCE CAREERBook provides FUNDAMENTAL KNOWLEDGE for young scientists contemplating a variety of career pathsKENNETH J. BARRCite this: Chem. Eng. News 2008, 86, 39, 44–45Publication Date (Print):September 29, 2008Publication History Published online14 November 2010Published inissue 29 September 2008https://pubs.acs.org/doi/10.1021/cen-v086n039.p044https://doi.org/10.1021/cen-v086n039.p044book-reviewACS PublicationsCopyright © 2008 AMERICAN CHEMICAL SOCIETYArticle Views13Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Graduate education Get e-Alerts
The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses (2017)

Current influenza treatment relies on a single class of antiviral drugs, the neuraminidase inhibitors (NAIs), raising concern over the potential emergence of resistant variants and necessitating the development of novel drugs. In recent years, investigational inhibitors targeting the endonuclease activity of the influenza acidic polymerase (PA) protein have yielded encouraging results, although there are only limited data on their <i>in vivo</i> efficacy. Here, we examined the antiviral potential of the PA endonuclease inhibitor RO-7 in prophylactic and therapeutic regimens in BALB/c mice inoculated with influenza A/California/04/2009 (H1N1)pdm09 or B/Brisbane/60/2008 viruses, which represent currently circulating antigenic variants. RO-7 was administered to mice intraperitoneally twice daily at dosages of 6, 15, or 30 mg/kg/day for 5 days, starting 4 h before or 24 or 48 h after virus inoculation, and showed no adverse effects. Prophylactic administration completely protected mice from lethal infection by influenza A or B virus. The level of therapeutic protection conferred depended upon the time of treatment initiation and RO-7 dosage, resulting in 60 to 100% and 80 to 100% survival with influenza A and B viruses, respectively. RO-7 treatment significantly decreased virus titers in the lung and lessened the extent and severity of lung damage. No PA endonuclease-inhibitor resistance was observed in viruses isolated from lungs of RO-7-treated mice, and the viruses remained susceptible to the drug at nanomolar concentrations in phenotypic assays. These <i>in vivo</i> efficacy results further highlight the potential of RO-7 for development as antiviral therapy for influenza A and B virus infections.
Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression. (1985)

The mechanism by which prostaglandin E2 (PGE2) inhibits human T lymphocyte activation and proliferation was studied. We analyzed the effect of physiologic concentrations of PGE2 on interleukin 2 (IL 2) production, expression of IL 2 receptor (Tac antigen), and expression of the transferrin receptor after in vitro activation with phytohemagglutinin. PGE2 inhibited T lymphocyte proliferation by 80 to 90% of control values. This was associated with a similar degree of inhibition of IL 2 production while the expression of IL 2 receptor was not affected. This was in marked contrast to the expression of the transferrin receptor, which was inhibited 65% after 72 hr of in vitro activation. The addition of exogenous, purified IL 2 reconstituted lymphocyte proliferation to 50% of control values, but had no effect on transferrin receptor expression. Because PGE2 is known to increase the intracellular concentration of 3',5' cyclic adenosine monophosphate (cAMP), we investigated the effect of another adenylate cyclase activator, i.e., isoproterenol, as well as the effect of extracellular administration of the cAMP derivative dibutyryl cAMP (dBcAMP) on IL 2 production, Tac antigen expression, and transferrin receptor expression. It was demonstrated that isoproterenol, as well as dBcAMP, inhibited transferrin receptor expression on PHA-activated T lymphocytes to the same extent as PGE2, and exogenous IL 2 could not counteract the down-regulation of the receptor expression. In contrast, neither isoproterenol nor dBcAMP had any significant effect on IL 2 receptor expression. Prostaglandin F2 alpha (PGF2 alpha), which has been reported to elevate intracellular cyclic GMP levels, had no effect on lymphocyte activation and proliferation, and did not counteract the PGE2-induced depression in IL 2 production. In contrast to its effect on peripheral blood lymphocytes, PGE2 had no effect on transferrin receptor expression or cell proliferation by IL 2-dependent T cell clones and IL 2-independent T cell lines. These studies demonstrate that PGE2 exerts its inhibitory effects on T cell activation and proliferation via two distinct pathways: inhibition of IL 2 production and inhibition of transferrin receptor expression. The transferrin receptor inhibition is mediated via the cAMP pathway and is IL 2-independent.
Mobility in high-K metal gate UTBB-FDSOI devices: From NEGF to TCAD perspectives (2013)

This paper aims to review important theoretical and experimental aspects of both electrostatics and channel mobility in High-K Metal Gate UTBB-FDSOI MOSFETs. A simulation chain, including advanced quantum solvers, and semi-empirical Technology Computer Assisted Design (TCAD) tools is presented.
Synthesis of Chitosan-Stabilized Polymer Dispersions, Capsules, and Chitosan Grafting Products via Miniemulsion (2002)

The potential of chitosan as an emulsion stabilizer is combined with the miniemulsion technique to generate oil droplets, hollow capsules, and latex particles in the diameter range of 100-300 nm carrying a functional biopolymer surface. It turned out that chitosan alone, independent of its molecular weight, is just moderately efficient, which is speculatively attributed to its stiff polysaccharide structure. The addition of biocompatible costabilizers with higher flexibility either to the oil phase or to the water phase, such as Jeffamine or Gluadin (a peptide), eliminates these deficiencies, and very small nanocapsules made of biopolymer hybrids can be obtained. NMR analysis shows that the costabilizer is effectively grafted/cross-linked to the chitosan which makes the miniemulsion route also effective for the modification of hard-to-handle, amphiphilic biopolymers either from the water or from the oil phase.
Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis (2023)

PROSPERO ID 89366.
Activation of human B lymphocytes. XIV. Characterization of the precursor of the pokeweed mitogen-induced anti-sheep red blood cell plaque-forming cell. (1979)

The precursor of the pokeweed mitogen (PWM)-induced anti-sheep red blood cell (SRBC) plaque-forming cell (PFC) in human peripheral blood was characterized. By a variety of purification procedures, it was demonstrated to be a lymphocyte with surface characteristics of a B cell. Furthermore, it was demonstrated to bind to sheep erythrocytes (E) and thus segregated with the E-rosetting T cells when T cell enrichment was performed by differential fractionation of E-rosetting cells. This binding of the PFC precursor to E was blocked by pretreating the lymphocyte with anti-human Ig before E rosetting, indicating that the PFC precursor specifically bound to SRBC by a surface Ig molecule with binding specificity for sheep red blood cell determinants. Hence, the precursor of the PWM-triggered anti-SRBC PFC is a B lymphocyte with surface Ig expressing specificity for SRBC.
A Macrochip Interconnection Network Enabled by Silicon Nanophotonic Devices (2010)

We present an advanced wavelength-division multiplexing point-to-point network enabled by silicon nanophotonic devices. This network offers strictly non-blocking all-to-all connectivity while maximizing bisection bandwidth, making it ideal for multi-core and multi-processor interconnections. We introduce one of the key components, the nanophotonic grating coupler, and discuss, for the first time, how this device can be useful for practical implementations of the wavelength-division multiplexing network using optical proximity communications. Finite difference time-domain simulation of the nanophotonic grating coupler device indicates that it can be made compact (20 microm x 50 microm), low loss (3.8 dB), and broadband (100 nm). These couplers require subwavelength material modulation at the nanoscale to achieve the desired functionality. We show that optical proximity communication provides unmatched optical I/O bandwidth density to electrical chips, which enables the application of wavelength-division multiplexing point-to-point network in macrochip with unprecedented bandwidth-density. The envisioned physical implementation is discussed. The benefits of such an interconnect network include a 5-6x improvement in latency when compared to a purely electronic implementation. Performance analysis shows that the wavelength-division multiplexing point-to-point network offers better overall performance over other optical network architectures.
Direct combination (1999)

This paper reports on Direct Combination, a new user interaction technique. Direct Combination may be viewed variously as: a systematic extension to Direct Manipulation; a concise navigational framework to help users find the operations they need; and as a framework to make a greater range and variety of operations available to the user, without overburdening user or interface designer. While Direct Combination may be seen as an extension of Direct Manipulation, it may also be applied to a wide range of user interaction styles, including even command line interfaces. Examples from various hypothetical systems and from an implemented system are presented. This paper argues that Direct Combination is applicable not just to problem seeking or design oriented domains (where the technique originated) but is generally applicable. A variety of new interaction styles for Direct Combination are presented. The generalisation of Direct Combination to the n-dimensional case is presented.
Phase field modeling of domain structures in ferroelectric materials (2004)

A phase field model based on the work of Hu and Chen has been computationally implemented. The approach uses a minimization of global free energy to simulate the evolution of domain structures through the time dependent Ginzburg-Landau equation. The work focuses on the assumptions made when setting up the free energy function and the effect of these assumptions on the behavior of the model. Polarization is used as the independent variable. A fourth order polynomial is used to create four energy minima that represent the tetragonal phase in the two-dimension simulations. Linear superposition is used to modify the energy to account for the effects of sterss, electric field, and polarization gradients. This approach neglects field concentrations associated with material anisotropy and local geometric features. Considerable work will be required to incorporate these effects.
Characteristics of the Swirling Flow in a Multipoint LDI Combustor (2007)

An experimental investigation was conducted to study the aerodynamic characteristics of the non-reacting, swirling flow field associated with a Multipoint Swirl-Venturi Lean Direct Injection (LDI) combustor. There are 9 fuel injectors designed to fit within a 76.2 mm square area, which is approximately the same area of a conventional fuel injector. Each individual fuel injector has a helical axial-vaned swirler with a short internal convergentdivergent venturi to provide rapid mixing of the fuel and air and to provide a small recirculation zone for burning. The fuel injector is inserted through the center of swirler and the fuel tip is at the throat of the venturi. All the swirlers have same tip vane angles of 60o with the calculated swirl number of 1.0. Two different swirler arrangements were investigated experimentally, which include a co-swirling array, where all swirlers acted in the same direction, and a counter-swirling array, where the swirl direction alternated for adjacent swirlers. A 3-D Particle Image Velocimetry (PIV) system was employed to investigate the instantaneous vortex structure of the swirling flow and to measure the mean velocity components and Reynolds stresses. A two-component Laser Doppler Velocimetry (LDV) system was employed to get the benchmark quality data which are planned for validating the state-of-the-art numerical models in addition more advanced LES approach. Detailed experimental data are provided to improve mechanistic understanding of the multipoint swirler generated flow field. The experimental results indicate that the flow structures change significantly as compared with the single swirler test. There are very strong interactions among the adjacent swirlers near the swirler exit.
Osteogenic Protein-1 (OP-1) Expression and Processing in Chinese Hamster Ovary Cells: Isolation of a Soluble Complex Containing the Mature and Pro-Domains of OP-1 (1994)

We have characterized the expression and processing of Osteogenic Protein-1 (hOP-1), a bone morphogenic protein of the TGF-beta family, in Chinese hamster ovary cells. The hOP-1 is initially synthesized as a monomeric 50 kDa pro-protein that is dimerized, glycosylated, and then proteolytically cleaved at the Arg-Xaa-Xaa-Arg maturation site in an acidic cellular compartment before secretion into the medium. Of the four potential N-linked glycosylation sites two are used, one in the mature domain and one in the pro-domain. Gel permeation chromatography of secreted hOP-1 in physiological buffers yields an apparent molecular weight of 110-120 k, indicating that after proteolytic processing the two pro-domains remain non-covalently associated with the disulfide linked mature dimer in a complex termed soluble hOP-1. Purified soluble hOP-1 is significantly more soluble in physiological buffers than the purified mature OP-1.
In silico investigation of intracranial blast mitigation with relevance to military traumatic brain injury (2010)

Blast-induced traumatic brain injury is the most prevalent military injury in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head, and still less is known about how personal protective equipment affects the brain's response to blasts. In this study we investigated the effect of the Advanced Combat Helmet (ACH) and a conceptual face shield on the propagation of stress waves within the brain tissue following blast events. We used a sophisticated computational framework for simulating coupled fluid-solid dynamic interactions and a three-dimensional biofidelic finite element model of the human head and intracranial contents combined with a detailed model of the ACH and a conceptual face shield. Simulations were conducted in which the unhelmeted head, head with helmet, and head with helmet and face shield were exposed to a frontal blast wave with incident overpressure of 10 atm. Direct transmission of stress waves into the intracranial cavity was observed in the unprotected head and head with helmet simulations. Compared to the unhelmeted head, the head with helmet experienced slight mitigation of intracranial stresses. This suggests that the existing ACH does not significantly contribute to mitigating blast effects, but does not worsen them either. By contrast, the helmet and face shield combination impeded direct transmission of stress waves to the face, resulting in a delay in the transmission of stresses to the intracranial cavity and lower intracranial stresses. This suggests a possible strategy for mitigating blast waves often associated with military concussion.
Electrochemically Stable High Energy Density Lithium-Sulfur Batteries (2022)

Lithium-Sulfur batteries (LSB) have emerged as one of the strong contenders for high energy density rechargeable batteries in the Li-ion battery domain. The LSB system is considered as the most promising to achieve the next milestone in energy density of 500 Wh/kg. However, the LSB system is plagued with problems of polysulfide formation which are soluble in the organic electrolyte leading to loss in capacity and eventual cell failure. The problem is further compounded by dendrite formation on the Li anode during electrochemical cycling leading to puncturing of the separator causing eventual short-circuiting of the cell and consequent heat generation resulting in major safety hazards of flammability of the organic liquid electrolyte and impending explosion. This chapter describes various approaches developed to combat both cathode and anode issues. These involve synthesis and characterization of complex framework materials (CFMs) for confining the polysulfides and sulfur in the LSB cathodes. The CFMs include a CFM host and a coating applied to the CFM host, which includes one or more form of an electronic conductor, a lithium-ion conductor and a functional electrocatalyst for electrocatalytically converting the soluble polysulfides to Li2S. Further, sulfur is infiltrated into the CFM host creating a sulfur-carbon linkage serving as effective anchors for trapping the ensuing polysulfides. The systems have been tested in coin cells and pouch cells with metallic Li anodes under lean electrolyte conditions of 3-4 μl/mg of electrolyte (E) to sulfur (S) ratios showing promise and feasibility. New emergent dendrite-free alloys have also been identified to test against pure Li and CFM cathodes in coin cell and pouch cell configurations under lean electrolyte conditions. Results of these studies are described and discussed with thoughts on future directions.
On the Capacity of Memoryless Rewritable Storage Channels (2014)

A number of modern storage technologies, when written to, exhibit substantial variability in the outcome of a write action. It is possible to mitigate the effect of the write uncertainty through the use of a feedback loop that rewrites the memory whenever judged necessary, in effect reshaping the write noise. This scheme highlights a tradeoff between the storage capacity of the memory and the cost of writing to it, measured for example in the number of rewrites. We have developed the model of a rewritable channel to provide an explicit form for this tradeoff and study other performance characteristics of such memories. In this paper, we describe some initial results on the information-theoretic analysis of the rewritable channel. We first consider the problem of determining the capacity of this channel with input cost constraints, and obtain a variety of results from which we extract insights that we believe are of value to memory designers. Our results include an upper bound on capacity of the form log (Γκ), where Γ is a constant that can be easily calculated from the channel's statistics and κ is an average cost parameter. We also provide a lower bound on capacity with a similar form. We analyze the particular case of uniform write noise in detail, obtaining a closed form expression for the capacity-cost tradeoff for all possible cost parameters. We explore this formula from the capacity per unit cost perspective and establish that in order to achieve optimal energy and memory-wear per bit, it is sometimes strictly better to take advantage of the rewriting capability as opposed to writing only once; this observation has significant practical implications. We also include a discussion of the relevance of our work to real emerging memory technologies.
An Arcminute Resolution Search at 4.7CM^-1 for Point Sources in Msam and Max Fields (1994)

We have searched for mm-wave emission from compact objects in two fields, each approximately 1 square degree in size, taken from regions of the sky in which degree-scale structure in the Cosmic Background Radiation (CBR) has recently been reported. The observations were made at frequency of 4.7~cm^-1 and with an angular resolution of 1.7' using the Sunyaev-Zel'dovich Infrared Experiment (SuZIE) bolometer array at the Caltech Submillimeter Observatory (CSO). The first field was centered on 14.92hr +82deg (1994.0), one of two regions in which Cheng et al. (1994) identify the signature of an unresolved point source seen during 0.5 degree resolution observations made at 5.6~cm^-1 with the Medium Scale Anisotropy Measurement (MSAM) experiment. The second field was centered on 15.47hr +72.4deg (1994.0), part of the Gamma Ursae Minoris (GUM) region where several prominent features have been detected by Devlin et al. (1994) in 0.55 degree-resolution observations made at 3.5 and 6~cm^-1 with the Millimeter Anisotropy eXperiment (MAX). We find that there is no point source in either field that can account for the structure observed at 0.5 degree resolution, and that the structure must arise from objects with an angular size greater than 2'.
The Antioxidant Effect of Mitochondrially Targeted Antioxidant SkQ1 on the Isolated Rat Heart Model (2022)

Mitochondrially targeted antioxidants based on Skulachev ions (SkQ1) are extremely attractive for neutralizing reactive oxygen species directly in the mitochondrial matrix. The aim was to examine the antioxidant and cardioprotective status of the SkQ1 mitochondrially targeted antioxidant in an isolated rat heart model of ischemia and reperfusion after cold cardioplegia. Material and methods. The effects of different concentrations of SkQ1 (1200 ng/ml, 120 ng/ml, 12 ng/ml) were explored on isolated hearts of Wistar rats ( n =50) during 240-min cold cardioplegia. The levels of oxidative stress, changes in myocardial damage markers (classical and highly specific) and cardiac function (coronary flow velocity, heart rate, systolic pressure) were assessed. Results. The use of SkQ1 at 12 ng/ml resulted in a significant neutralization of oxidative stress manifestations ( P &lt;0.05). The minimum concentration of NO metabolites (nitrates and nitrites) (36.2 [30.8; 39.8] µmol/ml) was maintained at pre-ischemic level throughout the 30-minute reperfusion period, while the malonic dialdehyde concentration (49.5 [41.1; 58.9] µmol/g) was lower compared with SkQ1 use at 120 ng/ml dose. Due to the «mitigation» of oxidative stress, intracellular enzymes and highly specific markers of myocardial damage rose more slowly during reperfusion, while cardiac function recovery occurred at a higher rate and showed stability upon restoration of perfusion. Conclusion. SkQ1 at 12 ng/ml concentration showed strong antioxidant and cardioprotective properties in an ex vivo study.
Two-Photon-Fluorescence Correlation Measurements of Picosecond Optical Pulses Generated from a 405-nm GaInN Laser Diode (2009)

Intensity auto-correlation measurements using two-photon fluorescence from a GaN crystal were performed on picosecond optical pulses from a 405-nm GaInN laser diode excited by intense electric pulses. The estimated pulse duration was 10 ps.