gebhart/patrepeval huggingface dataset:
Natural human interferon-alpha enhances the expression of intracellular adhesion molecule-1, integrin alpha 2 and beta 1 by a mucosal epithelial cell line. (1995)

We have found that pretreatment of a human oral mucosal epithelial cell line KB with natural human interferon-alpha (IFN-alpha) augments the expression of intercellular adhesion molecule-1 (ICAM-1), and the complex of CD29 and CD49b, which is known as very late antigen (VLA)-2, in a dose-dependent manner, whereas the expression of other adhesion molecules such as CD44 leukocyte function associated antigen-3 (LFA-3), VLA-4 and endothelial leukocyte adhesion molecule-1 (ELAM-1) did not show any significant changes under the same conditions. The pretreatment of KB cells with IFN-alpha also induces the adhesion of these cells to the human leukemia T cell line MOLT-16 and to peripheral T lymphocytes in a dose-dependent manner. However, the adhesion of the above-mentioned T cells to KB cells was not inhibited by specific antibodies against ICAM-1, CD29, and CD49b. The results thus show that adhesion molecules other than ICAM-1, CD29, AND CD49b are responsible for the induced adhesion between T cells and IFN-alpha-pretreated KB cells.
Power Reduction and BTI Mitigation of Data-Cache Memory Based on the Storage Management of Narrow-Width Values (2019)

Power dissipation of on-chip cache memories contributes a large portion of a processor's power consumption. Therefore, power management of cache memories is crucial in modern processors. On the other hand, bias temperature instability (BTI) is one of the most serious reliability concerns in SRAM-based on-chip memories. The effect of BTI on SRAM-cell transistors is manifested as their threshold-voltage shift over stress duration, which decreases the robustness of these structures. This paper presents a power consumption-reduction technique for data-cache memories, based on a storage management considering narrow-width values (NWVs), which additionally mitigates the BTI rate on the most aging susceptible SRAM cells of data-cache memory, as well. In the proposed technique, the most significant bits of data-cache memory words are stored in SRAM blocks that operate with lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> , to achieve the decrease of the related power consumption and aging rate. This is shown to reduce leakage-current and dynamic current of data-cache memory by 37.6% and 22.1%, respectively, besides improving its lifetime by up to 2.25x, all with negligible performance and area overheads.
Imaging of Renovascular Hypertension: Respective Values of Renal Scintigraphy, Renal Doppler US, and MR Angiography (2000)

Renovascular hypertension affects 15%-30% of patients who have clinical criteria suggestive of renovascular disease. Noninvasive screening is crucial for patient selection prior to conventional angiography and renal revascularization. Renal scintigraphy has been reported to be sensitive for detection of renovascular hypertension, but some of its limitations (eg, in the setting of bilateral renal artery stenosis and renal failure) should be considered. Doppler ultrasonography (US) allows direct evaluation of the renal arteries as well as transrenal Doppler waveform analysis, but it remains operator dependent. Gadolinium-enhanced magnetic resonance (MR) angiography is becoming an excellent alternative to conventional angiography. The main limiting factors of this technique are inadequate visualization of segmental and accessory renal arteries as well as a tendency toward overestimation of stenoses. Given the high cost and low availability of MR angiography, scintigraphy and Doppler US should be considered the primary studies in screening for renovascular hypertension. MR angiography could be reserved for patients with inconclusive scintigraphic and Doppler US results, patients with high clinical suspicion of renovascular hypertension, and patients with a contraindication to conventional angiography.
Supplementary Figure Legend 1 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas (2023)

Supplementary Figure Legend 1 from Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas
Interannual variability in summer Beaufort Sea ice conditions: Relationship to winter and summer surface and atmospheric variability (2003)

Interannual variations in the Beaufort Sea summer ice cover influence climatic, ecological, and socioeconomic conditions. Utilizing an ice severity index based on the distance from Point Barrow, Alaska, to the ice edge and characteristics of the shipping season, variations in summer ice conditions are examined from 1953 through 2000 with respect to variations in winter and summer surface and meteorological conditions. Although there is no significant trend in the ice severity index, ice conditions during the 1990s were less severe than in previous decades. Interannual variations in summer ice conditions are related to dynamical mechanisms in the preceding winter and dynamical and thermodynamical processes during summer. In winters preceding light ice summers, high pressure develops over Siberia, leading to increased ice transport across the Transpolar Drift Stream, while the Beaufort Gyre is diminished, resulting in decreased multiyear ice transport into the Beaufort Sea. Air temperatures are also elevated near the Alaskan North Slope, but there is little difference in winter air temperature over the Beaufort Sea. During light ice summers the Beaufort High is strongly defined over the Canadian Arctic Archipelago, enhancing easterly and northerly winds and advecting sea ice out of the Beaufort Sea. Above‐normal air temperatures also occur over much of the southern Beaufort Sea. Variations in sea level pressure and winds that result in light and heavy ice summers are closely linked to positive and negative winter Arctic Oscillation/North Atlantic Oscillation phases, as well as negative and positive summer Arctic Oscillation/North Atlantic Oscillation phases.
Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T (2018)

The human hippocampus plays a key role in memory management and is one of the first structures affected by Alzheimer's disease. Ultra-high magnetic resonance imaging provides access to its inner structure in vivo. However, gradient limitations on clinical systems hinder access to its inner connectivity and microstructure. A major target of this paper is the demonstration of diffusion MRI potential, using ultra-high field (11.7 T) and strong gradients (750 mT/m), to reveal the extra- and intra-hippocampal connectivity in addition to its microstructure. To this purpose, a multiple-shell diffusion-weighted acquisition protocol was developed to reach an ultra-high spatio-angular resolution with a good signal-to-noise ratio. The MRI data set was analyzed using analytical Q-Ball Imaging, Diffusion Tensor Imaging (DTI), and Neurite Orientation Dispersion and Density Imaging models. High Angular Resolution Diffusion Imaging estimates allowed us to obtain an accurate tractography resolving more complex fiber architecture than DTI models, and subsequently provided a map of the cross-regional connectivity. The neurite density was akin to that found in the histological literature, revealing the three hippocampal layers. Moreover, a gradient of connectivity and neurite density was observed between the anterior and the posterior part of the hippocampus. These results demonstrate that ex vivo ultra-high field/ultra-high gradients diffusion-weighted MRI allows the mapping of the inner connectivity of the human hippocampus, its microstructure, and to accurately reconstruct elements of the polysynaptic intra-hippocampal pathway using fiber tractography techniques at very high spatial/angular resolutions.
TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia (2015)

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia and dysregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease based on transgenic mouse studies. To determine a role of microRNAs on the pathogenesis of the aggressive form of CLL we studied regulation of TCL1 expression in CLL by microRNAs. We identified miR-3676 as a regulator of TCL1 expression. We demonstrated that miR-3676 targets three consecutive 28-bp repeats within 3'UTR of TCL1 and showed that miR-3676 is a powerful inhibitor of TCL1. We further showed that miR-3676 expression is significantly down-regulated in four groups of CLL carrying the 11q deletions, 13q deletions, 17p deletions, or a normal karyotype compared with normal CD19(+) cord blood and peripheral blood B cells. In addition, the sequencing of 539 CLL samples revealed five germ-line mutations in six samples (1%) in miR-3676. Two of these mutations were loss-of-function mutations. Because miR-3676 is located at 17p13, only 500-kb centromeric of tumor protein p53 (Tp53), and is codeleted with Tp53, we propose that loss of miR-3676 causes high levels of TCL1 expression contributing to CLL progression.
Figure S7 from High-Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor Therapy (2023)

&lt;p&gt;Figure S7. Immune memory effects in mice treated with HIFU+ Î±CTLA-4 + Î±PD-L1&lt;/p&gt;
Comparative Studies on Schistosomulicidal Activity of Mouse and Rat Eosinophils (1997)

Eosinophils from interleukin (IL)-5 transgenic mice were shown to have antibody-dependent killing activity against the larvae of Schistosoma japonicum. However, in comparison with rat eosinophils, the schistosomulicidal activity of mouse eosinophils was lower. Flow cytometric analysis of the cells binding to mouse immunoglobulins demonstrated that rat cells were superior to mouse cells in the binding of mouse IgG. However, the adherence and schistosomulicidal activity of mouse cells were inhibited by rat anti-mouse Fcgamma receptor monoclonal antibody. These results suggest that the mechanism of killing by mouse eosinophils is mediated by IgG antibodies.
Epidural empyema following thoracic extradural block (1974)

✓ An unusual case of epidural sepsis with subsequent paraparesis following the placement of a thoracic epidural catheter for the maintenance of a postoperative analgesic block is reported. The hazards of this technique are reviewed.
Unique Ergodicity in the Interconnections of Ensembles with Applications to Two-Sided Markets (2021)

There has been much recent interest in two-sided markets and dynamics thereof. In a rather a general discrete-time feedback model, which we show conditions that assure that for each agent, there exists the limit of a long-run average allocation of a resource to the agent, which is independent of any initial conditions. We call this property the unique ergodicity. Our model encompasses two-sided markets and more complicated interconnections of workers and customers, such as in a supply chain. It allows for non-linearity of the response functions of market participants. Finally, it allows for uncertainty in the response of market participants by considering a set of the possible responses to either price or other signals and a measure to sample from these.
<title>Laser-Induced Damage And Two-Photon Absorption Measurements In CdTe</title> (1982)

We report the results of laser-induced damage and nonlinear absorption measured for CdTe and other selected II-VI materials. These studies were conducted using pulsed 1.06 pm radiation from a Nd:YAG laser. The laser pulsewidth was varied from approximately 40 psec to 9,000 psec (9 nsec). The lasernduced breakdown irradiance measured for CdTe over this pulsewidth range scaled as tp <sup>-1/2</sup> [tp is the laser pulsewidth (FWHM)]. Nonlinear phtoacoustic spectroscopy was used to monitorPthe nonlinear and linear absorption in the samples in which laser-induced damage thresholds were measured.
Computational imaging enables a “see-through” lens-less camera (2018)

Conventional cameras obscure the scene that is being recorded. Here, we place an image sensor (with no lens) on the edge of a transparent window and form images of the object seen through that window. This is enabled first, by the collection of scattered light by the image sensor, and second, by the solution of an inverse problem that represents the light scattering process. Thereby, we were able to form simple images, and demonstrate a spatial resolution of about 0.1 line-pairs/mm at an object distance of 150mm with depth-of-focus of at least 10mm. We further show imaging of two types of objects: an LED array and a conventional LCD screen. Finally, we also demonstrate color and video imaging.
Identity for NPMLE in Missing and Biased Sampling Models. (2001)

We derive an identity for NPMLE in non-parametric missing data models and biased sampling models, which almost says that the NPMLE is ecient. Application of empirical process theory to the identity provides us with a straightforward consistency and eciency proof. The identity is illustrated with the random truncation model.
Atmospheric pressure chemical ionization and atmospheric pressure photoionization for simultaneous mass spectrometric analysis of microbial respiratory ubiquinones and menaquinones (2004)

An atmospheric pressure photoionization (APPI) source and an atmospheric pressure chemical ionization (APCI) source were compared for the selective detection of microbial respiratory ubiquinone and menaquinone isoprenologues using tandem mass spectrometry. Ionization source- and compound mass-dependent parameters were optimized individually for both sources, using the available quinone standards. Detection levels for the two ion sources were determined with ubiquinone-6 (UQ6) and menaquinone-4 (MK4, vitamin K2) standards using flow injection analysis and selected reaction monitoring (SRM). With APPI the calculated lower limit of detection (LLOD) was 1.7 fmol microl(-1) for UQ6 and 2.2 fmol microl(-1) for MK4 at a signal-to-noise ratio of 3. These LLODs were at least three times lower than with APCI. The selectivity of detection afforded by SRM detection reduced complex mixture analysis to 3 min per sample by eliminating the need for chromatographic separations. The detection method was successfully applied to quinone quantification in a variety of environmental samples and cell cultures. Adequate amounts of respiratory quinones can be extracted and quantified from samples containing as low as 2 x 10(7) cells.
Crystallization and preliminary X-ray crystallographic study of the editing domain ofThermus thermophilusisoleucyl-tRNA synthetase complexed with pre- and post-transfer editing-substrate analogues (2004)

The CP1 domain (the editing domain) of isoleucyl-tRNA synthetase (IleRS) hydrolyzes misactivated Val-AMP in pre-transfer editing and mischarged Val-tRNA(Ile) in post-transfer editing. The CP1 domain of Thermus thermophilus IleRS was expressed in isolation, purified and cocrystallized with Val-AMS (a Val-AMP analogue) and with Val-2AA (a Val-tRNA(Ile) analogue). Two different expression constructs were used for each cocrystallization. The complex crystals with Val-AMS belong to the tetragonal space group P4(1)2(1)2, with unit-cell parameters a = b = 102.00, c = 84.88 A. The asymmetric unit contains two molecules of the CP1 domain, with a corresponding crystal volume per protein weight of 2.7 A3 Da(-1) and a solvent content of 53.5%. The complex crystals with Val-2AA belong to the tetragonal space group P4(1)22, with unit-cell parameters a = b = 72.59, c = 83.68 A. The asymmetric unit contains one molecule of the CP1 domain, with a corresponding crystal volume per protein weight of 2.8 A3 Da(-1) and a solvent content of 55.8%. Data sets diffracting to 1.7 A resolution were collected from each single crystal at 100 K.
Increased vaccination efficiency with apoptotic cells by silica-induced, dendritic-like cells. (2002)

We have demonstrated previously the ability of apoptotic cells to prime a functional immune response using an i.p. vaccination protocol with apoptotic cells and interleukin 2, before injecting a lethal dose of tumor cells into syngeneic rats. This protocol resulted in a survival rate of 33%. To elucidate the nature and the activity of the phagocytes involved in the clearance of apoptotic cells in vivo, we modulated the peritoneal cavity environment by administrating either thioglycollate or silica i.p. before injecting the apoptotic cells. Our results showed that thioglycollate abrogated vaccination efficiency, because none of the rats survived under these conditions. In fact, thioglycollate treatment induced a massive recruitment and activation of inflammatory macrophages that efficiently engulfed apoptotic cells, bypassing induction of specific immune responses. In contrast, silica treatment enhanced the vaccination efficiency of apoptotic cells plus interleukin 2 up to 66%. We distinguished a population of dendrite-like cells among the cells derived from the silica-treated peritoneal cavity both by their phenotype (MHC II(+)/CD80(+)/CD86(+)) and by their ability to induce the proliferation of allogeneic T cells in a mixed leukocyte reaction. Our results demonstrate the different roles of macrophages and dendritic-like cells in the physiological clearance of dead tumor cells and their implication in the design of immunomodulating vaccines.
A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells (2011)

The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-κB-dependent release of TNF-α/IFN-γ. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.
The pathognomonic FOXL2 C134W mutation alters DNA binding specificity (2020)

Abstract The somatic missense point mutation c.402C&gt;G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumours (AGCT) and a diagnostic marker for this tumour type. However, the molecular consequences of this mutation and its contribution to the mechanisms of AGCT pathogenesis remain unclear. To explore the mechanisms driving FOXL2 C134W pathogenicity we engineered V5-FOXL2 WT and V5-FOXL2 C134W inducible isogenic cell lines and performed ChIP-seq and transcriptome profiling. We found that FOXL2 C134W associates with the majority of the FOXL2 WT DNA elements as well as a large collection of unique elements genome-wide. We confirmed an altered DNA binding specificity for FOXL2 C134W in vitro and identified unique targets of FOXL2 C134W including SLC35F2 whose expression increased sensitivity to YM155 in our model. Statement of Significance Mechanistic understanding of FOXL2 C134W induced regulatory state alterations drives discovery of a rationally designed therapeutic strategy.
Submodule Integrated Distributed Maximum Power Point Tracking for Solar Photovoltaic Applications (2012)

This paper explores the benefits of distributed power electronics in solar photovoltaic applications through the use of submodule integrated maximum power point trackers (MPPT). We propose a system architecture that provides a substantial increase in captured energy during partial shading conditions, while at the same time enabling significant overall cost reductions. This is achieved through direct integration of miniature MPPT power converters into existing junction boxes. We describe the design and implementation of a high-efficiency (>;98%) synchronous buck MPPT converter, along with digital control techniques that ensure both local and global maximum power extraction. Through detailed experimental measurements under real-world conditions, we verify the increase in energy capture and quantify the benefits of the architecture.
Experimenting with services over an information-centric integrated satellite-terrestrial network (2013)

Abstract: The recent paradigm shift in the Internet’s usage, from the host-centric to a content-centric communication model, where users request information irrespectively of its location, is coupled with an increasing need for converged and seamless access over heterogeneous wired and wireless networks. By integrating satellite communication components into a publish-subscribe Information-Centric Networking (ICN) architecture, we jointly exploit the capabilities and advantages of each: transparent use of terrestrial multicasting and satellite broadcasting, content-based traffic engineering, multipath transfer, in-network caching capabilities, and seamless mobility. Experimenting over a realized integrated-terrestrial ICN testbed, we demonstrate and illustrate key functionalities and gains for various services and applications. Keywords:
Supplementary Figure 3 from <i>In Vivo</i> Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB) (2023)

Supplementary Figure 3 from &lt;i&gt;In Vivo&lt;/i&gt; Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)
Figure S6 from Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer (2023)

&lt;p&gt;Supplemental Figure S6: In vivo expression of IGF-1R and ErbB3 in HPAF-II tumors over time.&lt;/p&gt;
Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances (2019)

In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular levels. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and functional information. However, it has limited applications in the field of molecular imaging due to its low sensitivity. To expand the capability of MRI to encompass molecular imaging applications, we introduced bioresponsive Gd(III)-based magnetic resonance contrast agents (GBCAs) in 1997. Since that time, many research groups across the globe have developed new examples of bioresponsive GBCAs. These contrast agents have shown great promise for visualizing several biochemical processes, such as gene expression, neuronal signaling, and hormone secretion. They are designed to be conditionally retained, or activated, <i>in vivo</i> in response to specific biochemical events of interest. As a result, an observed MR signal change can serve as a read-out for molecular events. A significant challenge for these probes is how to utilize them for noninvasive diagnostic and theranostic applications. This Perspective focuses on the design strategies that underlie bioresponsive probes, and describes the key advances made in recent years that are facilitating their application <i>in vivo</i> and ultimately in clinical translation. While the field of bioresponsive agents is embryonic, it is clear that many solutions to the experimental and clinical radiologic problems of today will be overcome by the probes of tomorrow.