gebhart/patrepeval huggingface dataset:
Metal-metal charge transfer in thallous tetracarbonylcobaltate ion pairs. Spectroscopy and equilibrium constants (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-metal charge transfer in thallous tetracarbonylcobaltate ion pairs. Spectroscopy and equilibrium constantsCharles Schramm and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 1979, 101, 16, 4554–4558Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ja00510a021https://doi.org/10.1021/ja00510a021research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding the molecular interactions of lipopolysaccharides during E. coli initial adhesion with a surface forces apparatus (2011)

Lipopolysaccharides (LPS) occupy 75% of the surface of Gram-negative bacteria. This work investigates the role of LPS during bacterial adhesion to solid substrates. Two model lipopolysaccharides, LPS1 and LPS2, were examined. LPS1 from E. coliJM109 has a full LPS chain consisting of lipid A, core polysaccharides, and O-antigen; LPS2 from K12 has a truncated chain without the O-antigen portion. Interactions between an LPS layer prealigned on polystyrene (PS) and three different substrates (mica, PS-coated mica, and 3-aminopropyltriethoxysilane (APTES)-functionalized mica) in 0.1 M NaCl were measured using a surface forces apparatus (SFA). The PS-supported LPS showed strong adhesion to APTES, weak adhesion to mica, and strong repulsion to PS substrate. Electrostatic interaction and steric effects contribute significantly to the interactions between the LPS and different substrates. The presence of long O-antigen chains in LPS1 reduces bacterial adhesion to various substrates because of the presence of an energetic barrier during the adsorption process, which is caused by the affinity of hydrophilic neutral O-antigen chains to water and the steric entropic barrier of LPS chains on the cell membrane surface.
The Dynamics of High-Speed Sliding Power Collection Systems for Electrically Propelled Vehicles (1974)

A method is presented for estimating the contact force variation between a collector brush and a rigid third rail when the third rail has a surface with random irregularity. Results are obtained for a reference case where the third rail roughness is estimated from the roughness of other known surfaces. The surface roughness of an actual commercial third rail is measured and the results are used to estimate the performance of a collector on the measured sample at 300 mph. Conclusions are drawn about the feasibility of power collection at 300 mph.
Unexpected reduction pathway of a Co2+salt to [HCo(CO)4] via [Co2(CO)8] in an ionic liquid (2006)

In the 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ionic liquid ([BMI][NTf(2)]), [Co(NTf(2))(2)] is reduced under 5.5 MPa of H(2)-CO to [Co(2)(CO)(8)] prior to [HCo(CO)(4)], provided a pyridine ligand is present in the medium.
Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer (2010)

Subgroups of patients with non-endometrioid endometrial cancer and defective MMR may have improved survival after adjuvant radiotherapy. Patients with advanced stage endometrial cancer and defects in mismatch repair may receive less benefit from adjuvant chemotherapy.
Highlighting the impact of aging on type I collagen: label-free investigation using confocal reflectance microscopy and diffuse reflectance spectroscopy in 3D matrix model (2016)

During aging, alterations of extracellular matrix proteins contribute to various pathological phenotypes. Among these alterations, type I collagen cross-linking and associated glycation products accumulation over time detrimentally affects its physico-chemical properties, leading to alterations of tissue biomechanical stability. Here, different-age collagen 3D matrices using non-destructive and label-free biophotonic techniques were analysed to highlight the impact of collagen I aging on 3D constructs, at macroscopic and microscopic levels. Matrices were prepared with collagens extracted from tail tendons of rats (newborns, young and old adults) to be within the physiological aging process. The data of diffuse reflectance spectroscopy reveal that aging leads to an inhibition of fibril assembly and a resulting decrease of gel density. Investigations by confocal reflectance microscopy highlight poor-fibrillar structures in oldest collagen networks most likely related to the glycation products accumulation. Complementarily, an infrared analysis brings out marked spectral variations in the Amide I profile, specific of the peptidic bond conformation and for carbohydrates vibrations as function of collagen-age. Interestingly, we also highlight an unexpected behavior for newborn collagen, exhibiting poorly-organized networks and microscopic features close to the oldest collagen. These results demonstrate that changes in collagen optical properties are relevant for investigating the incidence of aging in 3D matrix models.
Probabilistic cooperative localization and mapping in practice (2004)

In this paper we present a probabilistic framework for the reduction in the uncertainty of a moving robot pose during exploration by using a second robot to assist. A Monte Carlo Simulation technique (specifically, a Particle Filter) is employed in order to model and reduce the accumulated odometric error. Furthermore, we study the requirements to obtain an accurate yet timely pose estimate. A team of two robots is employed to explore an indoor environment in this paper, although several aspects of the approach have been extended to larger groups. The concept behind our exploration strategy has been presented previously and is based on having one robot carry a sensor that acts as a "robot tracker" to estimate the position of the other robot. By suitable use of the tracker as an appropriate motion-control mechanism we can sweep areas of free space between the stationary and the moving robot and generate an accurate graph-based description of the environment. This graph is used to guide the exploration process. Complete exploration without any overlaps is guaranteed as a result of the guidance provided by the dual graph of the spatial decomposition (triangulation) of the environment. We present experimental results from indoor experiments in our laboratory and from more complex simulated experiments.
Multiple window time-frequency and time-scale analysis (1996)

We propose an extension of Thomson's multiple window spectrum estimation for stationary random processes to the time-varying spectrum estimation of non-stationary random processes. Unlike previous extensions of Thomson's method, in this paper we identify and utilize optimally concentrated window and wavelet functions for the time-frequency and time-scale planes respectively. Moreover, we develop a statistical test for detecting and extracting chirping line components.
Detecting laser-induced phase change at the surface of solids via latent heat of melting with a photothermal deflection technique (1994)

The detection of laser-induced melt at the surface of a solid in real time is demonstrated using a photothermal deflection (PTD) technique. Experimental results for indium and tin show that a local maximum and minimum pair can occur in the temporal profile of the PTD signal when melt occurs. A local minimum does not occur without phase change. Analytical work is presented which explicitly shows the effect of the latent heat of melting, thermal properties, and probe-beam size and offset on the shape of a PTD signal. Results are presented which demonstrate that the observed change in shape will not occur with planar heating, with or without phase transition. However, results derived for point-source heating show that it is possible for the maximum/minimum pair to occur when melting with a focused laser beam. The ratio of the sensible heat to the latent heat, and the ratio of the thermal diffusivities of the target and deflecting medium are the key factors which govern the deflection response. Computations for a general class of materials are given to show when the effect of latent heat can be observed at a surface. Results are also given which consider the probe-beam size and offset on the observations.
A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes (2014)

Abstract The emergence of next generation DNA sequencing technology is enabling high-resolution cancer genome analysis. Large-scale projects like the International Cancer Genome Consortium (ICGC) are systematically scanning cancer genomes to identify recurrent somatic mutations. Second generation DNA sequencing, however, is still an evolving technology and procedures, both experimental and analytical, are constantly changing. Thus the research community is still defining a set of best practices for cancer genome data analysis, with no single protocol emerging to fulfil this role. Here we describe an extensive benchmark exercise to identify and resolve issues of somatic mutation calling. Whole genome sequence datasets comprising tumor-normal pairs from two different types of cancer, chronic lymphocytic leukaemia and medulloblastoma, were shared within the ICGC and submissions of somatic mutation calls were compared to verified mutations and to each other. Varying strategies to call mutations, incomplete awareness of sources of artefacts, and even lack of agreement on what constitutes an artefact or real mutation manifested in widely varying mutation call rates and somewhat low concordance among submissions. We conclude that somatic mutation calling remains an unsolved problem. However, we have identified many issues that are easy to remedy that are presented here. Our study highlights critical issues that need to be addressed before this valuable technology can be routinely used to inform clinical decision-making. Abbreviations and Definitions SSM Somatic Single-base Mutations or Simple Somatic Mutations, refers to a somatic single base change SIM Somatic Insertion/deletion Mutation CNV Copy Number Variant SV Structural Variant SNP Single Nucleotide Polymorphisms, refers to a single base variable position in the germline with a frequency of &gt; 1% in the general population CLL Chronic Lymphocytic Leukaemia MB Medulloblastoma ICGC International Cancer Genome Consortium BM Benchmark aligner = mapper, these terms are used interchangeably
Integrated mode-evolution-based polarization splitter (2005)

A mode-evolution-based polarization splitter suitable for high-index-contrast systems and directly integratable with a recently reported on-polarization rotator is described and its performance verified through both finite-difference time-domain and eigenmode expansion simulations. For a device length of 200??m, greater than 22?dB of extinction is obtained across a 1.45–1.75-?m bandwidth.
A New Data Detection Method for 35 Gbit/inch2 Multilevel Recording Using a Blue Laser and 0.85 Numerical Aperture Optics (2006)

In this study, a commercial Blu-ray disc was used for multilevel recording. The goal is to make its present capacity 2 times larger and data transfer rate 2 times faster. This technology is a promising candidate for improving extending the standard of the Blu-ray disc. To achieve this specification corresponding to an areal density of 36 Gbit/in.2, the bit length is reduced to 56 nm. The features of technology for 36 Gbit/in.2 are as follows: First, eight-level recording is adopted. Second, a new detection method named cell boundary data detection (CBDD) is developed to overcome severe intersymbol interference (ISI) from outer cells at a small cell length. Finally, we use the same optical pickup as that of the Blu-ray disc for doubling areal density. CBDD utilizes data sampled at the cell boundary, which is almost free of the influence of ISI without an equalizer. In addition, the popular error correction code of Bose–Chaudhuri–Hocquenghem (BCH) is applied to the part of the least-significant bit (LSB). As a result, CBDD with the BCH code achieved a bER of 1 ×10-5 at the effective bit length of 57.6 nm, which indicates an areal density of 35 Gbit/in.2 by computer simulation. Moreover, we experimentally obtained a bER of less than 1 ×10-5 using CBDD with the BCH code at a cell length of 200 nm.
Comparison of two optimized readout chains for low light CIS (2014)

We compare the noise performance of two optimized readout chains that are based on 4T pixels and featuring the same bandwidth of 265kHz (enough to read 1Megapixel with 50frame/s). Both chains contain a 4T pixel, a column amplifier and a single slope analog-to-digital converter operating a CDS. In one case, the pixel operates in source follower configuration, and in common source configuration in the other case. Based on analytical noise calculation of both readout chains, an optimization methodology is presented. Analytical results are confirmed by transient simulations using 130nm process. A total input referred noise bellow 0.4 electrons RMS is reached for a simulated conversion gain of 160&mu;V/e&minus;. Both optimized readout chains show the same input referred 1/f noise. The common source based readout chain shows better performance for thermal noise and requires smaller silicon area. We discuss the possible drawbacks of the common source configuration and provide the reader with a comparative table between the two readout chains. The table contains several variants (column amplifier gain, in-pixel transistor sizes and type).
Shifted positioning of the anticodon nucleotide residues of amber suppressor tRNA species by Escherichia coli arginyl‐tRNA synthetase (2001)

Cytidine in the anticodon second position (position 35) and G or U in position 36 of tRNAArg are required for aminoacylation by arginyl-tRNA synthetase (ArgRS) from Escherichia coli. Nevertheless, an arginine-accepting amber suppressor tRNA with a CUA anticodon (FTOR1Delta26) exhibits suppression activity in vivo [McClain, W.H. & Foss, K. (1988) Science, 241, 1804-1807]. By an in vitro kinetic study with mutagenized tRNAs, we showed that the arginylation of FTOR1Delta26 involves C34 and U35, and that U35 can be replaced by G without affecting the activity. Thus, the positioning of the essential nucleotides for the arginylation is shifted to the 5' side, by one residue, in the suppressor tRNAArg. We found that the shifted positioning does not depend on the tRNA sequence outside the anticodon. Furthermore, by a genetic method, we isolated a mutant ArgRS that aminoacylates FTOR1Delta26 more efficiently than the wild-type ArgRS. The isolated mutant has mutations at two nonsurface amino-acid residues that interact with each other near the anticodon-binding site.
Safety and feasibility of outpatient induction chemotherapy with CPX-351 in selected older adult patients with newly diagnosed AML. (2018)

e19013 Background: Liposomal Daunorubicin and Cytarabine (Vxyeos) was recently approved for the treatment of Therapy Related Acute Myeloid Leukemia and AML with Myelodysplastic Related Changes having demonstrated superior overall survival (OS) when compared to traditional daunorubicin + cytarabine induction (7+3). Beyond improved OS, there are other potential benefits. While 7+3 requires hospitalization, Vyxeos is delivered over 90 minutes on days 1, 3 and 5. With a goal of reducing the duration of hospitalization, we piloted outpatient induction chemotherapy with Vyxeos. Methods: The Inpatient/Outpatient (IPOP) program involves close monitoring of patients who receive traditionally inpatient chemotherapy as outpatients. Candidates for Vyxeos induction were screened for IPOP. Those with increased risk for tumor lysis including white count > 50K, increased creatinine/uric acid, active cardiopulmonary symptoms, ECOG > 2, or those who lacked a caregiver or were unable to reside within 60 minutes of the treating facility were excluded. Eligible patients received Vyxeos through IPOP. Daily CBC, CMP, uric acid, and phosphorus were performed and patients were evaluated each day. On day 6, each patient was admitted to the hospital for continued care. Results: Twenty-two patients received a full course of induction with Vyxeos. Fourteen (64%) received induction in IPOP and 8 received inpatient induction (Median Age: 68.6,65.1 respectively). 1 of 14 outpatients (7%) was admitted on day 2 of induction due to hypotension and a fall. The remaining 13 outpatients (93%) tolerated outpatient Vyxeos and were hospitalized on day 6 as planned for continued care. One patient who received Vyxeos as an inpatient died prior to Day 30. Mean hospitalization duration was 28.3 and 30.5 days for IPOP and Inpatient delivery respectively. Conclusions: In this pilot study, outpatient delivery of liposomal daunorubicin and cytarabine in selected patients appears to be both feasible and safe, significantly reducing the length of hospitalization for induction chemotherapy. Future analyses will study longer-term patient outcomes and financial implications utilizing this approach.
Response of Campylobacter jejuni to combinations of ferrous sulphate and cadmium chloride (1988)

On Mueller Hinton (MH) agar, Campylobacter jejuni showed 20.0 and 30.9 mm zones of inhibition surrounding discs impregnated with 2.5 and 20 micrograms CdCl2 respectively. The minimal inhibitory concentration (MIC) ranged from 0.64 to 3.2 micrograms CdCl2/ml of MH agar for four C. jejuni strains. In the presence of 23 micrograms FeSO4/ml of MH the MIC increased to a range of 1.5-5.4 micrograms CdCl2/ml of MH. Moreover, the numbers of colonies present on MH supplemented with FeSO4 were greater than on MH without iron. The growth response of C. jejuni in the presence of 0.025% (w/v) FeSO4 in MH broth was increased about 10,000 fold in three of four strains when compared with the growth in unsupplemented MH broth. Zones of inhibition surrounding 20 micrograms discs of CdCl, were 50.6 and 24.4 mm on MH and Campy-BAP media respectively, with cells grown on MH. These results suggest that the blood-containing medium 'neutralized' the biocidal influence of the CdCl2. In comparison, C. jejuni inoculum from fluid thioglycollate (FT) medium showed smaller zones of inhibition. These decreased from 34.9 mm on MH agar to 19.6 mm on Campy-BAP agar, suggesting that components in the FT growth medium ameliorated the toxic influence of CdCl2. Atomic absorption spectroscopy analysis indicated mean values (mg/100 g dry weight) of selected metals bound by C. jejuni as: Cu, 10.4; Mg, 146; Na, 2385; Fe, 45.1; Zn, 13.0; and K, 172.
Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects (2006)

Coincidence of the beneficial graft-vs.-tumor (GVT) effects and the detrimental graft-vs.-host disease (GVHD) remains the major obstacle against the widespread use of allogeneic bone marrow transplantation (BMT) as tumor immunotherapy. We here demonstrate that intervention of MAdCAM-1 (mucosal vascular addressin cell adhesion molecule-1) or fractalkine/CX3CL1 after the expansion of allo-reactive donor CD8 T cells selectively inhibits the recruitment of effector donor CD8 T cells to the intestine and alleviates the graft-vs.-host reaction (GVHR) associated intestinal injury without impairing GVT effects. In a nonirradiated acute GVHD model, donor CD8 T cells up-regulate the expression of intestinal homing receptor alpha4beta7 and chemokine receptors CXCR6 and CX3CR1, as they differentiate into effector cells and subsequently infiltrate into the intestine. Administration of anti-MAdCAM-1 antibody or anti-fractalkine antibody, even after the expansion of alloreactive donor CD8 T cells, selectively reduced the intestine-infiltrating donor CD8 T cells and the intestinal crypt cell apoptosis without affecting the induction of donor derived anti-host CTL or the infiltration of donor CD8 T cells in the hepatic tumor. Moreover, in a clinically relevant GVHD model with myeloablative conditioning, these antibodies significantly improved the survival and loss of weight without impairing the beneficial GVT effects. Thus, interruption of alpha4beta7-MAdCAM-1 or CX3CR1-fractalkine interactions in the late phase of GVHD would be a novel therapeutic approach for the separation of GVT effects from GVHR-associated intestinal injury.
An analytical model of planar inductors on lowly doped silicon substrates for high frequency analog design up to 3 GHz (2002)

An analytical model for planar inductors in air or on lowly doped substrates has been introduced. The model parameters have been fitted by means of electromagnetic simulation and its validity has been verified with measurement results. In this paper it has also been shown how this analytical model can be used to gain a better insight in technology, layout and design trade-off's.
Liposome Based Intravesical Therapy Targeting Nerve Growth Factor Ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis (2016)

Nerve growth factor over expression in the bladder mucosa and bladder hypersensitivity induced after colitis were decreased by intravesical application of liposome-oligonucleotide targeting nerve growth factor. This suggests that local antinerve growth factor therapy could be effective treatment of bladder symptoms in chronic pelvic pain syndrome.
Study of dislocations in AlN single-crystal using bright-field synchrotron x-ray topography under a multiple-beam diffraction condition (2020)

Dislocations in an AlN single crystal were studied via bright-field synchrotron x-ray topography under a multiple-beam diffraction (MBD) condition. Two-beam approximation conditions using nine different types of diffraction vectors (g) were applied, including five types near the MBD condition, and the Burgers vector (b) of dislocations was identified using the g·b invisibility criterion. Based on the assignment of the Burgers vectors, some of the propagation behaviors of the dislocation were observed, including dislocation reduction via a reaction between threading edge-type dislocations and the generation of a pair of dislocations that have opposite Burgers vectors.
Recombinant tumor necrosis factors mediate platelet cytotoxicity to Schistosoma mansoni larvae. (1988)

The involvement of platelets in the immunity directed toward the parasite Schistosoma mansoni has been demonstrated in vitro and in vivo. The killing properties of platelets were shown previously to involve specific IgE after their binding to a membrane receptor. More recently, we have demonstrated that lymphokines released by S. mansoni Ag- or lectin-stimulated CD4+/CD8-T cells were able to induce the platelet cytotoxicity. The isoelectric focusing of the T lymphocyte supernatants showed that two factors were able to stimulate the platelet killing functions. One of them was clearly identified as being IFN-gamma. The present work demonstrates that the second lymphokine was TNF. Indeed the rTNF-beta and, to a lesser extent, rTNF-alpha, induce normal platelets into killer cells for the young larvae of schistosome. Moreover, an additive effect of the TNF-alpha and IFN-gamma has been observed.