gebhart/patrepeval huggingface dataset:
O4‐06‐05: Aβ immunization in old mouse lemur primates induces cerebral microhemorrhages and accelerates age‐associated iron deposits in the choroid plexus (2012)

Anti-amyloid immunotherapy reduces Aβ plaques and prevents cognitive decline in transgenic mouse models of Alzheimer's disease (AD) (Asuni et al, 2006). Nevertheless, in humans, a strategy based on Aβ1-42 peptide induced encephalomyelitis and possibly microhemorrhages (Orgogozo et al, 2003; Ferrer et al, 2004). These outcomes were not expected from studies in rodents. Mouse lemur, as a primate model may be more predictive of human side effects. A small proportion of old animals develop spontaneously Aβ plaques (Mestre-Francès et al, 2000). Thus this primate models prodromal AD stages, and we used it to evaluate side effects of immunotherapies. Animals were treated with K6Aβ1-30 (n = 4; 5.8±0.2 years) or Aβ1-42 (n = 4; 5.9±0.2 years) immunogens in alum adjuvant. They were followed-up for 9 months with biochemistry (anti-Aβ40 antibodies and Aβ40 levels in the plasma), as well as T2-weighted (T2w) and T2-weighted (T2w) MRI (7T PharmaScan-Bruker; resolutions=(234x234x234)μm3. Histological analyses was performed to evaluate amyloidosis, neuroinflammation, and iron deposits/microhemorrhages. Age-associated occurrences of hypointense signals were evaluated in twenty other naive animals (1.5 to 4.9 years). In this particular study, the animals responded mainly to the Aβ1-42 immunogen, which differs from our prior study with this Aβ derivative (Trouche et al, 2009). This treatment induced an immune response and increased Aβ levels in plasma. No severe neuroinflammation were observed (either on MRI or histology). Compared to K6Aβ1-30 vaccine, Aβ1-42 immunogen increased microhemorrhages (Mann Whitney test U=1, P<0.05) and the size of hypointense signal corresponding to iron deposits in the choroid plexus (CP) (F(2,5)=4.627; P<0.05). The study in naive lemurs showed that iron accumulates in the CP with normal aging (r=0.60; P<0.001). Hence, immunotherapy with Aβ1-42 immunogen accelerated this age-associated phenomenon. Aβ-immunization can lead to side effects such as microhemorrhages in a primate model of normal aging or prodromal stage of AD with minimal extracellular Aβ deposition. Also, iron accumulation in the CP is a potential side effect of Aβ-immunization. This should be taken into account in future evaluations of clinical trials with AD patients.
B0 concomitant field compensation for MRI systems employing asymmetric transverse gradient coils (2017)

A user-transparent method to compensate the zeroth-order concomitant field term by center frequency shifting is proposed and implemented. This solution allows all the existing pulse sequences-both product and research-to be retained without any modifications. Magn Reson Med 79:1538-1544, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Broadband Electric-Field-Induced Second Harmonic Generation in a Silicon Waveguide (2019)

We demonstrate group-velocity-matched electric-field-induced second harmonic generation in silicon ridge waveguides with a broad conversion bandwidth of 80 nm for a 2.48 µm pump wavelength and a maximum efficiency of 112 ±13%W−1 using 200 fs pump pulses.
Noninvasive pulmonary transit time: A new parameter for general cardiac performance (2017)

CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.
Designing Biostable Polyurethane Elastomers for Biomedical Implants. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Personality Estimation from Japanese Text. (2016)

We created a model to estimate personality trait from authors’ text written in Japanese and measured its performance by conducting surveys and analyzing the Twitter data of 1,630 users. We used the Big Five personality traits for personality trait estimation. Our approach is a combination of category- and Word2Vec-based approaches. For the category-based element, we added several unique Japanese categories along with the ones regularly used in the English model, and for the Word2Vec-based element, we used a model called GloVe. We found that some of the newly added categories have a stronger correlation with personality traits than other categories do and that the combination of the category- and Word2Vec-based approaches improves the accuracy of the personality trait estimation compared with the case of using just one of them.
Design of Extreme Connector Stacking in PCI Express Interface (2007)

This paper describes the electrical architecture and design of the PCI express interface in the Blade Centertrade (J.E. Hughes et al., 2000) system. A comprehensive electrical design methodology, including accurate and detailed modeling and simulation of the complete design space, is required in order to achieve the speeds required by this interface, while using low-cost printed circuit board materials. In this paper, some of the obstacles and solutions to support 2.5 Gb/s to 5 Gb/s data transmission over multiple boards and multiple connector technologies are highlighted. Pre-layout analysis was performed to predict the interconnect performance for relatively long trace lengths in FR-4 material across four connectors in order to satisfy the PCI express design requirements and guarantee the overall performance objective of the system. Signal integrity affects (including frequency dependent losses, inter-symbol-interference (ISI), crosstalk, impedance discontinuities, via and pad capacitance effects and skew) were integrally analyzed across the complete design space. The solution provided was stack connector arrangements integrated into the PCI express link. The benefit was greater density, but a product that could be customized. This paper concludes the correlation between a post route simulation result and lab measurements. The correlation of simulation results with hardware measurements provided a high confidence in the simulation methodology, which could be relied upon in developing the broader set of PCB based design guidelines.
Parche Sierpinksi Perturbado (2000)

The multiband behavior of the Sierpinski patch is described in this paper, and a new technique to improve such multiband behavior from the point of view of radiation patterns is also introduced.
Compact, Hybrid III-V/Silicon Vernier Laser Diode Operating From 1955–1992 nm (2021)

The 2 m waveband is capable of enabling pervasive applications. The demonstration of the hollow-core photonic bandgap fiber and the thulium-doped fiber amplifier has highlighted the fiber propagation and amplification aspects of fiber communications, indicating its potential as an adjunct to present communication infrastructure at the O/C bands. The above is especially imperative given the current concerns with regards to the upper bandwidth limit of the single-mode fiber. Furthermore, the waveband could facilitate many more applications such as LIDAR and free-space communication. However, water absorption (OH-) is high at most of the 2 m waveband and this will impact the optical insertion loss of applications implemented in the wavelength region. The relative low water absorption region of the waveband falls within 1950 2000 nm. As such, the development of a hybrid/heterogeneous III-V/silicon laser source that operates within the region is important for 2 m silicon photonics. In this work, we demonstrate a -/Si hybrid tunable laser operating from 1955 - 1992 nm for the first time. Room temperature continuous wave operation is achieved with a maximum laser output power of 8.1 mW. This wavelength-tunable laser operates specifically within the low water absorption window, indicating good wavelength suitability for applications at the 2 m waveband.
Scaled spintronic logic device based on domain wall motion in magnetically interconnected tunnel junctions (2018)

We present a scaled device based on magnetic domain wall (DW) transport for logic applications. The device consists of multiple magnetic tunnel junctions (MTJs) connected by the same magnetic free layer (FL). Magnetic domain walls are injected by spin-transfer torque (STT) at the input MTJs and are sensed by tunneling magnetoresistance (TMR) at the output MTJ after propagation through the FL. Logic functions can be built by merging several domain walls. By enabling real-time detection of long range DW transport, we demonstrate a spintronic component which can be used for either Boolean or non-Boolean logic.
Parent Ion Spectrum (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy's Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Compact, Wideband Antennas Enabled by Interdigitated Capacitor-Loaded Metasurfaces (2016)

In this paper, a class of integrated metasurface (MS)-based planar antennas are proposed, which are fed by monopoles operating below their fundamental modes. Various interdigitated capacitor (IC) loading schemes for a metallic sheet backed MS are investigated, which provide footprint miniaturization and bandwidth enhancement. A linearly polarized (LP) MS-based antenna, loaded by ICs, provides a 15% impedance bandwidth and a gain higher than 6.67 dBi. The radiation mechanism and resonant frequency dependence were revealed via a dispersion analysis, which serves to explain the working principle of the proposed antenna. Next, a miniaturized antenna with doubly loaded ICs was introduced, achieving an impedance bandwidth of 10%, a gain above 6 dBi, and a more than 30% footprint reduction. A more advanced compact, circularly polarized (CP) MS-based antenna with a compact footprint, and improved 3-dB axial ratio (AR) bandwidth were also presented, by introducing triangular IC and diagonal slot loadings to the MS. It is demonstrated that this antenna achieves an impedance bandwidth of 16%, a gain above 5.5 dBi, and an AR <;3 dB bandwidth of 10%. Three antenna prototypes were fabricated and measured, with good correspondence between the experimental results and simulation predictions, confirming the proposed design methodologies. These compact and well-performing MS-based antennas have promising potential for applications in modern wideband wireless systems.
Glial cell line-derived neurotrophic factor: Characterization of mammalian posttranslational modifications (2012)

Posttranslational modifications of GDNF influence its stability, which may be critical for its clinical use.
2D MXenes: Terahertz Properties and Applications (2020)

Electronic properties of 2D MXenes can be tuned by their chemistry and structure. We report on THz conductivity and ultrafast photoexcited carrier dynamics in several members of MXene family with high intrinsic free carrier densities and carrier mobility. We find that MXenes of different chemistries respond to photoexcitation in dramatically different ways, exhibiting behaviors from conductivity suppression to long-lived photoconductivity. We discuss applications of MXenes in a variety of electro-optical and THz devices.
Stereospecific formation of chelate sandwich compounds derived from o-aminobenzaldehyde and 2-amino-5-chlorobenzaldehyde by a metal-ion-induced rearrangement (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific formation of chelate sandwich compounds derived from o-aminobenzaldehyde and 2-amino-5-chlorobenzaldehyde by a metal-ion-induced rearrangementLarry T. Taylor and Daryle H. BuschCite this: Inorg. Chem. 1969, 8, 6, 1366–1371Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/ic50076a032https://doi.org/10.1021/ic50076a032research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
First observation ofB¯0→J/ψK+K−and search forB¯0→J/ψϕdecays (2013)

The first observation of the ${\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{K}^{+}{K}^{\ensuremath{-}}$ decay is presented with a data sample corresponding to an integrated luminosity of $1.0\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of $pp$ collisions at a center-of-mass energy of 7 TeV collected with the LHCb detector. The branching fraction is measured to be $\mathcal{B}({\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{K}^{+}{K}^{\ensuremath{-}})=(2.53\ifmmode\pm\else\textpm\fi{}0.31\ifmmode\pm\else\textpm\fi{}0.19)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}$, where the first uncertainty is statistical and the second is systematic. An amplitude analysis of the final state in the ${\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{K}^{+}{K}^{\ensuremath{-}}$ decay is performed to separate resonant and nonresonant contributions in the ${K}^{+}{K}^{\ensuremath{-}}$ spectrum. Evidence of the ${a}_{0}(980)$ resonance is reported with statistical significance of 3.9 standard deviations. The corresponding product branching fraction is measured to be $\mathcal{B}({\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{a}_{0}(980),{a}_{0}(980)\ensuremath{\rightarrow}{K}^{+}{K}^{\ensuremath{-}})=(4.70\ifmmode\pm\else\textpm\fi{}3.31\ifmmode\pm\else\textpm\fi{}0.72)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$, yielding an upper limit of $\mathcal{B}({\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}{a}_{0}(980),{a}_{0}(980)\ensuremath{\rightarrow}{K}^{+}{K}^{\ensuremath{-}})&lt;9.0\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ at 90% confidence level. No evidence of the resonant decay ${\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}\ensuremath{\phi}$ is found, and an upper limit on its branching fraction is set to be $\mathcal{B}({\overline{B}}^{0}\ensuremath{\rightarrow}J/\ensuremath{\psi}\ensuremath{\phi})&lt;1.9\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ at 90% confidence level.
Embryogenic cell suspension culture induction and plantlet regeneration ofRauvolfia serpentina(L.) Benth.: influence of different plant growth regulator concentrations and combinations (2016)

Establishment of embryogenic cell suspension culture from the embryogenic callus culture of Rauvolfia serpentina (L.) was attempted by transferring 4–6 weeks-old asynchronous embryogenic calli raised from mature embryo and cotyledon explants cultures in liquid media. The cultures obtained were inundated mostly with clumps of proliferating globular embryos with modest non-embryogenic tissues. The number and size of somatic embryos/clumps was recorded to calculate growth of embryogenic tissues under various conditions. Initiation and proliferation of embryogenic suspension culture was influenced by various exogenous plant growth regulators fortified to the culture medium at variable magnitude. For the establishment of suspension cultures, MS medium fortified with 2.0 mg l−12,4-D with 0.5 mg l−1 BAP was found to be the most effective. For subsequent subculturing, the reduced level of 2,4-D (1.0 mg l−1) in combination with 0.5 mg l−1 BAP promoted somatic embryogenesis at a faster rate. Frequent and efficient plantlet regeneration occurred on MS medium supplemented with 0.5 mg l−1, each of BAP, TDZ and NAA. Higher in vitro rooting response (root proliferating efficiency, number of roots and mean root length) was exhibited by MS rooting medium amended with 0.1 mg l−1 IBA. A combination of 65% relative humidity and 28°C temperature regime exhibited higher survival of regenerated plantlets (∼95%) followed by 60% RH and 30°C (∼90%). Later approximately 85% plants survived after transplantation in the field.
High-Throughput Fire Testing for Intumescent Coatings (2006)

A new small-scale fire test is described in this paper. The goal was to design a high-throughput test permitting the optimization of intumescent mastic coatings formulated to protect steel in the case of hydrocarbon fire. This type of coating, applied on steel plates, beams, or columns, is usually evaluated in large industrial furnaces. Such experiments are expensive and time-consuming. The development of a small-scale laboratory test using an external heat flux is investigated. Temperature as a function of time is recorded on the back of the coated steel panel. It is shown that temperature profiles are very well correlated with those measured in industrial furnaces. This low-cost and fast test is very repeatable, and it allows rapid screening of a large number of different coating formulations. The test also shows good correlation with the results obtained in cellulosic fire testing.
Proteomics profiling of nontumor liver tissues identifies prognostic biomarkers in hepatitis B‐related hepatocellular carcinoma (2022)

Hepatocellular carcinoma (HCC) often occurs following chronic hepatitis B virus (HBV) infection, leading to high recurrence and a low 5-year survival rate. We developed an overall survival (OS) prediction model based on protein expression profiles in HBV-infected nontumor liver tissues. We aimed to demonstrate the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction. A univariate Cox and differential expression analysis were performed to identify candidate prognostic factors. A multivariate Cox analysis was performed to develop the liver gene prognostic index (LGPI). The survival differences between the different risk groups in the training and validation cohorts were also estimated. A total of 363 patients, 159 in the training cohort, and 204 in the validation cohort were included. Of the 6478 proteins extracted from nontumor liver tissues, we identified 1275 proteins altered between HCC and nontumor liver tissues. A total of 1090 out of 6478 proteins were significantly related to OS. The prognostic values of the proteins in nontumor tissues were mostly positively related to those in the tumor tissues. Protective proteins were mainly enriched in the metabolism-related pathways. From the differentially expressed proteins, the top 10 most significant prognosis-related proteins were submitted for LGPI construction. In the training and validation cohorts, this LGPI showed a great ability for distinguishing patients' OS risk stratifications. After adjusting for clinicopathological features, the LGPI was an independent prognostic factor in the training and validation cohorts. We demonstrated the prognostic value of protein expression profiling in nontumor liver tissues. The proposed LGPI was a promising predictive model for estimating OS in HBV-related HCC.
Data from Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530 (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Tumor-associated macrophages (TAMs) and the hyperactivation of the PI3K/AKT pathway are involved in the pathogenesis of Hodgkin lymphoma and affect disease outcome. Because the δ and γ isoforms of PI3K are overexpressed in Hodgkin/Reed–Sternberg (HRS) cells and the tumor microenvironment (TME), we propose that the PI3Kδ/γ inhibitor RP6530 might affect both HRS cells and TME, ultimately leading to an enhanced antitumor response.&lt;/p&gt;Experimental Design:&lt;p&gt;Hodgkin lymphoma cell lines (L-540, KM-H2, and L-428) and primary human macrophages were used to investigate the activity of RP6530 &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; in Hodgkin lymphoma cell line xenografts.&lt;/p&gt;Results:&lt;p&gt;&lt;i&gt;In vitro&lt;/i&gt;, RP6530 besides killing and inhibiting the proliferation of Hodgkin lymphoma cells, downregulated lactic acid metabolism, switching the activation of macrophages from an immunosuppressive M2-like phenotype to a more inflammatory M1-like state. By RNA sequencing, we define tumor glycolysis as a specific PI3Kδ/γ-dependent pathway implicated in the metabolic reprogramming of cancer cells. We identify the metabolic regulator pyruvate kinase M2 as the main mediator of tumor-induced immunosuppressive phenotype of macrophages. Furthermore, we show in human tumor xenografts that RP6530 repolarizes TAMs into proinflammatory macrophages and inhibits tumor vasculature, leading to tumor regression. Interestingly, patients with Hodgkin lymphoma experiencing objective responses (complete response and partial response) in a phase I trial using RP6530 showed a significant inhibition of circulating myeloid-derived suppressor cells and an average mean reduction in serum thymus and activation-regulated chemokine levels of 40% (range, 4%–76%).&lt;/p&gt;Conclusions:&lt;p&gt;Our results support PI3Kδ/γ inhibition as a novel therapeutic strategy that targets both malignant cells and the TME to treat patients with Hodgkin lymphoma.&lt;/p&gt;&lt;/div&gt;