gebhart/patrepeval huggingface dataset:
Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4 + T Cell Model without Inducing Global T Cell Activation (2011)

Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies.
Europium sulfide nanoprobes predict antiretroviral drug delivery into HIV-1 cell and tissue reservoirs (2021)

<b>Background:</b> Delivery of long-acting nanoformulated antiretroviral drugs (ARVs) to human immunodeficiency virus type one cell and tissue reservoirs underlies next generation antiretroviral therapeutics. Nanotheranostics, comprised of trackable nanoparticle adjuncts, can facilitate ARV delivery through real-time drug tracking made possible through bioimaging platforms. <b>Methods:</b> To model HIV-1 therapeutic delivery, europium sulfide (EuS) nanoprobes were developed, characterized and then deployed to cells, tissues, and rodents. Tests were performed with nanoformulated rilpivirine (NRPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI) used clinically to suppress or prevent HIV-1 infection. <i>First</i>, CD4+ T cells and monocyte-derived macrophages were EuS-treated with and without endocytic blockers to identify nanoprobe uptake into cells. <i>Second</i>, Balb/c mice were co-dosed with NRPV and EuS or lutetium<sup>177</sup>-doped EuS (<sup>177</sup>LuEuS) theranostic nanoparticles to assess NRPV biodistribution via mass spectrometry. <i>Third</i>, single photon emission computed tomography (SPECT-CT) and magnetic resonance imaging (MRI) bioimaging were used to determine nanotheranostic and NRPV anatomic redistribution over time. <b>Results:</b> EuS nanoprobes and NRPV entered cells through dynamin-dependent pathways. SPECT-CT and MRI identified biodistribution patterns within the reticuloendothelial system for EuS that was coordinate with NRPV trafficking. <b>Conclusions:</b> EuS nanoprobes parallel the uptake and biodistribution of NRPV. These data support their use in modeling NRPV delivery to improve treatment strategies.
Four-channel wavelength demultiplexer using polymer microstructure waveguides (1990)

Wavelength-division multiplexing and demultiplexing is recognized as a powerful means for increasing the channel density and bandwidth of data transmission and processing systems. 1 Herein, we report on the development of a new four-channel integrated-optic wavelength-division demultiplexer, using multiplexed waveguide holographic gratings patterned on a locally sensitized single-mode polymer (photo-lime gelatin) microstructure waveguide.
MiR‐124 Inhibits Myogenic Differentiation of Mesenchymal Stem Cells Via Targeting Dlx5 (2014)

MicroRNAs (miRNAs), including miR-1, miR-133, and miR-206, play a crucial role in muscle development by regulating muscle cell proliferation and differentiation. The aim of the present study was to define the effect of miR-124 on myogenic differentiation of mesenchymal stem cells (MSCs). The expression level of miR-124 in skeletal muscles was much lower than those in primary cultured bone marrow-derived MSCs and the bone, fat and brain tissues obtained from C57BL/6 mice. Myogenic stimuli significantly decreased the expression levels of miR-124 in mouse bone marrow-derived MSCs and C2C12 cells. Forced expression of miR-124 suppressed the expression of myogenic marker genes such as Myf5, Myod1, myogenin and myosin heavy chain and multinucleated myotube formation. Blockade of endogenous miR-124 with a hairpin inhibitor enhanced myogenic marker gene expression and myotube formation. During myogenic differentiation of MSCs and C2C12 cells, the levels of Dlx5, a known target of miR-124, were inversely regulated with those of miR-124. Furthermore, overexpression of Dlx5 increased myogenic differentiation, whereas knockdown of Dlx5 using siRNA inhibited myogenesis in C2C12 cells. These results suggest that miR-124 is a negative regulator of myogenic differentiation of MSCs and that upregulation of Dlx5 accompanied with downregulation of miR-124 by myogenic stimuli is necessary for the proper progression of myogenic differentiation.
Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species‐Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel (2022)

Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death, highlighting the urgent clinical need for effective therapies. Recently, tanshinone IIA has been identified as a promising therapeutic agent for myocardial infarction. However, efficient delivery remains a major issue that limits clinical translation. To address this problem, an injectable thermosensitive poly (lactic acid‐co‐glycolic acid)‐block‐poly (ethylene glycol)‐block‐poly (lactic acid‐co‐glycolic acid) gel (PLGA‐PEG‐PLGA) system encapsulating tanshinone IIA‐loaded reactive oxygen species‐sensitive microspheres (Gel−MS/tanshinone IIA) has been designed and synthesized in this study. The thermosensitive hydrogel exhibits good mechanical properties after reaching body temperature. Microspheres initially immobilized by the gel exhibit excellent reactive oxygen species‐triggered release properties in a high‐reactive oxygen species environment after myocardial infarction onset. As a result, encapsulated tanshinone IIA is effectively released into the infarcted myocardium, where it exerts local anti‐pyroptotic and anti‐inflammatory effects. Importantly, the combined advantages of this technique contribute to the mitigation of left ventricular remodeling and the restoration of cardiac function following tanshinone IIA. Therefore, this novel, precision‐guided intra‐tissue therapeutic system allows for customized local release of tanshinone IIA, presenting a promising alternative treatment strategy aimed at inducing beneficial ventricular remodeling in the post‐infarct heart.
Supplementary Figure Legends 1-8 from TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells (2023)

&lt;p&gt;PDF file - 38K&lt;/p&gt;
A new structural health monitoring system for real-time evaluation of building damage (2020)

The author has developed a new method for evaluating the seismic performance of existing structures from measured accelerations based on the capacity spectrum method. This involves comparing the performance curve, which is the equivalent nonlinear behavior of a simplified single-degree-of-freedom system, and the demand curve, which is the relationship between the response acceleration and displacement spectra. Two telecommunication towers in Japan were instrumented in 2016, and their responses during several earthquakes have been recorded. This paper discusses the evaluation of damage during the two earthquakes. Moreover, parameters such as the predominant period and the required performance are discussed. The proposed system evaluated both towers as being “elastic.” The damping ratios of the towers are very low, which caused the oscillations to continue for more than 5 min after the mainshock of each earthquake because of long-period components of the seismic motion
Supplementary Table S5 from Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with <i>BRAF</i><sup>V600</sup>-mutated Metastatic Melanoma (2023)

Supplementary Table S5 from Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;V600&lt;/sup&gt;-mutated Metastatic Melanoma
Early Glutamate-mediated Cell Death Detection with Digital Holographic Microscopy (2011)

We demonstrate the capability of digital holography to dynamically detect non-invasively cell death through the measurement of cellular volume regulation, considered as an early indicator of cellular deregulation, leading to cell death triggering.
Rare-Failure Oriented STT-MRAM Technology Optimization (2018)

A rare-failure oriented optimization methodology for state-of-the-art STT-MRAM technology has been proposed. Physics-based device models and novel rare event sampling algorithms are used for massively parallel Monte Carlo simulations to identify the critical process variability sources and to evaluate the Write Error Rate (WER) at the resolution of 1E-9. New rare-failure figure-of-merits (FoMs) and design guidelines are suggested for optimizing the operation conditions of STT-MRAMs so that the energy-delay product can be minimized at satisfactory WER level.
98 NX-0255, a small molecule CBL-B inhibitor, expands and enhances tumor infiltrating lymphocytes (TIL) for use in adoptive cancer immunotherapy (2021)

<h3>Background</h3> Adoptive cell transfer (ACT) of TIL effects durable responses in patients with melanoma and some epithelial tumors. It is thought that poor in vitro cell expansion and inefficient T-cell migration to the tumor limits the broader application of this approach. The E3 ubiquitin ligase, Casitas B-lineage lymphoma b (CBL-B) is expressed in T-cells where it functions as a regulator of immune cell activation, in part by requiring CD28 co-stimulation in addition to T-cell receptor activation. We have developed NX-0255, a highly potent small molecule inhibitor of CBL-B, demonstrating its ability to increase T-cell derived cytokine secretion and proliferation in the presence or absence of co-stimulation. Here, we investigated the effects of NX-0255 on the ex vivo growth and characteristics of human TIL to create drug-enhanced TIL (DeTIL-0255) as an ACT product for treating patients with cancer. <h3>Methods</h3> TIL from ovary, colon, lung, head and neck, breast, and vulva carcinomas were cultured with IL-2 and compared in two experimental groups: NX-0255 without IL-2, or NX-0255 in combination with IL-2. Following 22 days of culture, cell number, and phenotype were assessed by flow cytometry and single-cell transcriptomics. <h3>Results</h3> Culturing of TIL in the presence of NX-0255 alone resulted in the expansion of cells, with numbers comparable to that of conventionally cultured TIL with IL-2. The addition of NX-0255 in combination with IL-2 significantly increased the number of cells expanded compared to TIL (n=16, p=0.004). Flow cytometric analysis demonstrated that DeTIL-0255 were significantly less exhausted compared to TIL, as shown by the significant reduction of CD8+ T-cells expressing PD-1 (p=0.02), and co-expressing PD-1+TIM-3+ (p=0.03) and PD-1+LAG-3+ (p=0.03).Furthermore, upon stimulation, the functional capacity of DeTIL-0255 was differentially enhanced, with significant increases in the absolute numbers of CD8+ T-cells expressing intracellular perforin (p=0.001), granzyme-B (p=0.005) and CD107a (p=0.01) when comparing DeTIL-0255 to TIL. An increase of CD8+ T-cells expressing CD137/4-1BB, a biomarker of CD8+ T-cell tumor reactivity was also observed (p=0.03). TCR repertoire and single-cell sequencing analysis demonstrated that DeTIL-0255 had increased TCR diversity and enhanced expression of genes associated with stemness (CD127+,CCR7+,CD62L+) and cytotoxicity (GNLY+,GZMB+,NKG7+). <h3>Conclusions</h3> Collectively, these data suggest that DeTIL-0255 increases the proportion and absolute numbers of less exhausted CD8+ memory T-cells, enhancing cytolytic T-cell function. Adoptive transfer of DeTIL-0255 may increase persistence and exhibit broader functional activity than conventional TIL, potentially conferring improved anti-tumor activity. Taken together, these data support the clinical development of DeTIL-0255 for the treatment of patients with cancer.
Prediction of Vertebral Failure Load by Using X-Ray Vector Radiographic Imaging (2014)

The study results imply that XVR can improve the prediction of osteoporosis.
Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer (2015)

Elevated oxidative stress is an aberration seen in many solid tumors, and exploiting this biochemical difference has the potential to enhance the efficacy of anticancer agents. Homeostasis of reactive oxygen species (ROS) is important for normal cell function, but excessive production of ROS can result in cellular toxicity, and therefore ROS levels must be balanced finely. Here, we highlight the relationship between the extracellular matrix and ROS production by reporting a novel function of the matricellular protein Fibulin-5 (Fbln5). We used genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDAC) and found that mutation of the integrin-binding domain of Fbln5 led to decreased tumor growth, increased survival, and enhanced chemoresponse to standard PDAC therapies. Through mechanistic investigations, we found that improved survival was due to increased levels of oxidative stress in Fbln5-mutant tumors. Furthermore, loss of the Fbln5-integrin interaction augmented fibronectin signaling, driving integrin-induced ROS production in a 5-lipooxygenase-dependent manner. These data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.
Rotational analysis of congested spectra: Application of population labeling to the BaI C–X system (1981)

The rotational analysis of the congested spectra of the BaI radical is carried out by optical–optical double resonance method by exciting fluorescence. (AIP)
Mutations in the Regulatory Gene hrpG of Xanthomonas campestris pv. vesicatoria Result in Constitutive Expression of All hrp Genes (1999)

hrpG is a key regulatory gene for transcriptional activation of pathogenicity genes (hrp) of Xanthomonas campestris pv. vesicatoria. We identified three mutations in hrpG which render hrp gene expression constitutive in normally suppressing medium. The mutations in hrpG result in novel amino acid substitutions compared to mutations in related proteins, such as OmpR. In addition, mutated hrpG enhances the timing and intensity of plant reactions in infection assays.
Exploiting history to reduce interaction costs in collaborative analysis (2014)

When analysts work in a distributed fashion, they need to understand what their collaborators have done and what avenues of analysis remain uninvestigated. Although visualization history has the potential to communicate such information, the common representations are often limited to sequential lists of past work. Such representations do not make it easy to understand the analytic coverage of the dimension space (i.e. which dimensions have been investigated and which have not). This makes it difficult for an analyst to plan their next steps, particularly when the number of dimensions is large. In this paper, we propose representing the prior analysis from a dimension coverage perspective. Dimension view provides a unique perspective that can facilitate exploratory analysis by enabling analysts to easily identify what dimensions have been examined and in what combinations. We hypothesize that addition of this view to common representations of visualization history will reduce cognitive and interaction costs by helping the analyst to discover data subsets to explore. We studied the effects of this view on a distributed collaborative visualization process. Our findings show that providing views of the dimension and data space reduces time required for identifying and investigating unexplored regions and increases the accuracy of this understanding. In addition, providing these views results in a larger coverage of entire dimension space.
Sonic imaging: A tool for high‐resolution reservoir description (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Sonic imaging: A tool for high‐resolution reservoir descriptionAuthors: C. EsmersoyC. ChangM. R. KaneR. T. CoatesK. DoddsJ. ForemanC. EsmersoySchlumberger‐Doll Research, C. ChangSchlumberger‐Doll Research, M. R. KaneSchlumberger‐Doll Research, R. T. CoatesSchlumberger‐Doll Research, K. DoddsSchlumberger Wireline & Testing, and J. ForemanTexacohttps://doi.org/10.1190/1.1885883 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885883FiguresReferencesRelatedDetailsCited byInfluence of rock fractures on the amplitude of dipole-source reflected shear wave10 May 2019 | Applied Geophysics, Vol. 16, No. 1Reflection imaging away from borehole: A paradigm shiftXiaoming Tang1 September 2016Investigation of radiation and reflection on dipole logging-while-drilling remote acoustic reflection surveyZhoutuo Wei, Xiaoming Tang, and Jingji Cao1 September 2016Elastic wave scattering to characterize heterogeneities in the borehole environment29 February 2016 | Geophysical Journal International, Vol. 205, No. 1Experimental study of the azimuthal performance of 3D acoustic transmitter stations13 January 2016 | Petroleum Science, Vol. 13, No. 1Numerical simulation of radiation, reflection, and reception of elastic waves from a borehole dipole sourceZhou-Tuo Wei and Xiao-Ming Tang27 September 2012 | GEOPHYSICS, Vol. 77, No. 6Modeling sonic imaging of plane layering from an oblique boreholeRobert Burridge, Chung Chang, and Yong‐Hua Chen14 October 2009A modeling study of borehole radar for oil‐field applicationsYong‐Hua Chen and Michael L. Oristaglio17 September 2002 | GEOPHYSICS, Vol. 67, No. 5 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION C. Esmersoy, C. Chang, M. R. Kane, R. T. Coates, K. Dodds, and J. Foreman, (1997), "Sonic imaging: A tool for high‐resolution reservoir description," SEG Technical Program Expanded Abstracts : 278-281. https://doi.org/10.1190/1.1885883 Plain-Language Summary PDF DownloadLoading ...
Oxidation of Matrix Material in Helium with Varied Moisture Content (2019)

Exploration of the oxidation behavior of matrix material from tristructural-isotropic (TRISO) coated particle fuel elements in moisture environments provides critical data needed to predict the material’s response during off-normal accident scenarios. Near-representative, matrix-only samples were fabricated to facilitate oxidation testing in varied moisture concentrations. Oxidation testing was completed over a range of temperatures and oxidizing environments to obtain the relevant oxidation kinetics parameters and empirical oxidation rates necessary to better predict and understand matrix oxidation behavior at relevant conditions. The acquired oxidations rates were fit to established models for steam oxidation of nuclear graphite, and data were acquired following an established process. The data showed good agreement over conditions typical of the kinetic regime, and they showed a departure from the kinetic model fit at elevated temperatures and steam partial pressures in helium carrier gas. The departure was confirmed to be due to the experimental conditions being beyond the kinetic regime based on destructive analysis.
Cannulated screws for odontoid screw fixation and atlantoaxial transarticular screw fixation (1995)

Cannulated screw systems use thin Kirschner wires (K-wires) that have been drilled into the bone to direct screw trajectories accurately into small bone fragments. Use of the K-wires avoids overdrilling the pilot holes and allows fixation of adjacent bone fragments during screw insertion. Hollow tools and hollow screws are inserted into the bone over the K-wires. Cannulated screw fixation is useful in the cervical spine to stabilize odontoid fractures and to treat atlantoaxial instability. This report describes techniques for successful cannulated screw insertion and methods to minimize complications. Cannulated screws have several distinct advantages compared to noncannulated screws: 1) the K-wires guide the screw position into the bone; 2) the K-wire trajectory can be repositioned easily if the original trajectory was not ideal; 3) the K-wires allow continuous fixation of adjacent unstable bone fragments; and 4) the K-wires prevent migration of unstable bone fragments during screw insertion. Complications associated with the K-wire (breakage, repositioning, and advancement) can be minimized using precise operative techniques, a specialized tool system, and intraoperative fluoroscopic monitoring. A unique cannulated screw tool system was developed specifically for upper cervical fixation to allow percutaneous drilling using long tunneling devices, tissue sheaths, drill guides, and long K-wires. These tools allow delivery of cannulated fracture-fixation screws at a low angle to the spine through long soft-tissue trajectories. Cannulated screws have significant advantages compared to noncannulated screws for fixation of the unstable cervical spine.
Asymptotic analysis of full-duplex bidirectional MIMO link with transmitter noise (2013)

Bidirectional wireless communication between two multi-antenna terminals that operate in a full-duplex mode is considered. The effects of loopback self-interference and transmit-side noise due to radio front-end imperfections are analyzed in the asymptotic regime where the number of antennas at both terminals grows large. The study compares two transparent mitigation schemes by which conventional spatial multiplexing can operate without being aware of the self-interference issue: spatial-domain null-space projection and time-domain subtractive cancellation. Both schemes eliminate the information-bearing part of the self-interference perfectly, but due to transmitter imperfections, the cancellation approach suffers from residual self-interference. The receive-side null-space projection, on the other hand, suppresses also the transmit-side distortion, but at the cost of reduction in the degrees of freedom available for data reception. The results indicate that suppression becomes preferred when the level of transmit-side noise increases and the receiver does not have instantaneous knowledge about the spatial structure of the self-interference. Exhaustive Monte Carlo simulations also show that the asymptotic analytical results are useful for evaluating the performance of practical not-so-large systems.
Formal verification of human-robot teamwork (2009)

We here address the modelling and analysis of human-agent teamwork, specifically in the context of proposed astronaut-robot collaboration in future space missions. We are particularly interested in modelling such systems at a level that allows formal verification techniques to be applied, and hence carry out sophisticated analysis of the reliability and effectiveness of the teams before the system is deployed in real scenarios. In this paper we describe our ongoing research in this area.