gebhart/patrepeval huggingface dataset:
Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells (2011)

Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in retinal neurodegeneration, we used microarray techniques to compare gene expression profiles in this new model before and after retinal vasoregression. Differential gene expression was validated by quantitative RT-PCR, Western blot and immunofluorescence. Of the 157 genes regulated more than twofold, the MHC class II invariant chain CD74 yielded the strongest upregulation, and was allocated to activated microglial cells close to the vessels undergoing vasoregression. Pathway clustering identified genes of the immune system including inflammatory signaling, and components of the complement cascade upregulated during vasoregression. Together, our data suggest that microglial cells involved in retinal immune response participate in the initiation of vasoregression in the retina.
Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation (2011)

In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation. In this study, we analyzed the mechanism of estrogen action using two pubertal growth plate specimens of one girl at Tanner stage B2 and Tanner stage B3. Histological analysis showed that progression of puberty coincided with characteristic morphological changes: a decrease in total growth plate height (P=0.002), height of the individual zones (P<0.001), and an increase in intercolumnar space (P<0.001). Microarray analysis of the specimens identified 394 genes (72% upregulated and 28% downregulated) that changed with the progression of puberty. Overall changes in gene expression were small (average 1.38-fold upregulated and 1.36-fold downregulated genes). The 394 genes mapped to 13 significantly changing pathways (P<0.05) associated with growth plate maturation (e.g. extracellular matrix, cell cycle, and cell death). We next scanned the upstream promoter regions of the 394 genes for the presence of evolutionarily conserved binding sites for transcription factors implicated in growth plate maturation such as estrogen receptor (ER), androgen receptor, ELK1, STAT5B, cyclic AMP response element (CREB), and RUNX2. High-quality motif sites for RUNX2 (87 genes), ELK1 (43 genes), and STAT5B (31 genes), but not ER, were evolutionarily conserved, indicating their functional relevance across primates. Moreover, we show that some of these sites are direct target genes of these transcription factors as shown by ChIP assays.
Fatigue Behavior of Semi-Solid Formed A357-T6 Aluminum (2001)

&lt;div class="htmlview paragraph"&gt;The fundamental relationship between semi-solid processing and microstructure and their effect on the flow characteristics of semi-solid metals have been studied for several years. However, how the process related microstructure influences fatigue properties has not been given the same attention. This study examines the influence of process-related microstructure on the fatigue properties of semi-solid formed A357 alloys. High-solid-fraction (62% solid) and low-solid-fraction (31% and 36% solid) semi-solid formed A357 was tested in axial fatigue with a stress ratio (R) equal to -1. The high solid fraction (HSF) material had better fatigue properties than the low solid fraction (LSF) material. This is attributed to the fatigue crack initiation mechanisms, as related to the fatigue crack initiation features and the strengths of the materials.&lt;/div&gt;
[Values and limits of adenoviral vectors for gene transfer in vivo]. (1993)

Review of the therapeutic use of DNA transfer to treat a certain number of hereditary diseases (such as adenosine deaminase deficiency) or acquired diseases. The strategies (ex vivo manipulation or direct in vivo transfer of the corrective gene), vectors (retrovirus, adenovirus, nonviral vectors), and diseases which can benefit from gene therapy are considered and discussed together with an evaluation of the risk of gene therapy.
Personalising and Diversifying the Listening Experience (2020)

of June 2020, over 250 million monthly active users across 92 markets worldwide listening to over 60 million tracks and 1.5M podcast titles. We help this audio find the right audience via our recommendation products, which include playlist recommendation, playlist sequencing, and podcast show and episode recommendation. A large percentage of audio consumption is from Home, which make it valuable spaces for surfacing personalised and diverse content. This talk will present some of the research we completed on how to personalize the listening experience, and what diversity means in the context of a personalised listening experience.
Does magnesium modify left ventricular remodeling after experimental myocardial infarction? (1995)

Magnesium has no effect on early left ventricular remodeling or infarct expansion. The mechanism of its clinical benefits remains unexplained.
Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection (2021)

SLOCK (sensor for circadian clock) is an electrochemical sweat-based biosensing platform designed for the diagnosis and management of circadian abnormalities. Previously, the SLOCK platform was designed to detect adrenal steroids, cortisol, and DHEA for tracking the circadian rhythm. This work aims at tuning this SLOCK platform toward the detection of the cytokine, interleukin-31, for building a noninvasive, chronic disease diagnostics and management platform. This research provides a detailed characterization of the sensing surface and immunochemistry. The results show that SLOCK has good sensitivity to IL-31 concentrations in synthetic and human sweat. The limit of detection is 50 and 100 pg/mL for synthetic and human sweat, respectively. The dynamic range of the system is 50-1000 pg/mL, which encompasses the physiological ranges of 150-620 pg/mL. This is the first demonstration of sweat-based, label-free, electrochemical detection of IL-31. In addition to this, the data show good correlation (<i>R</i> <sup>2</sup> > 0.95) for the signal sensitivity to biomarker concentration. Finally, cross-reactivity studies highlight the specificity of SLOCK even in the presence of highly cross-reactive species. Thus, this novel SLOCK biosensor can be successfully used to track IL-31 in a sensitive and noninvasive manner and could be used to identify chronic pathophysiologies present in the body.
Translation: The Universal Structural Core of Life (2018)

The Universal Gene Set of Life (UGSL) is common to genomes of all extant organisms. The UGSL is small, consisting of <100 genes, and is dominated by genes encoding the translation system. Here we extend the search for biological universality to three dimensions. We characterize and quantitate the universality of structure of macromolecules that are common to all of life. We determine that around 90% of prokaryotic ribosomal RNA (rRNA) forms a common core, which is the structural and functional foundation of rRNAs of all cytoplasmic ribosomes. We have established a database, which we call the Sparse and Efficient Representation of the Extant Biology (the SEREB database). This database contains complete and cross-validated rRNA sequences of species chosen, as far as possible, to sparsely and efficiently sample all known phyla. Atomic-resolution structures of ribosomes provide data for structural comparison and validation of sequence-based models. We developed a similarity statistic called pairing adjusted sequence entropy, which characterizes paired nucleotides by their adherence to covariation and unpaired nucleotides by conventional conservation of identity. For canonically paired nucleotides the unit of structure is the nucleotide pair. For unpaired nucleotides, the unit of structure is the nucleotide. By quantitatively defining the common core of rRNA, we systematize the conservation and divergence of the translational system across the tree of life, and can begin to understand the unique evolutionary pressures that cause its universality. We explore the relationship between ribosomal size and diversity, geological time, and organismal complexity.
Mitigation of Initial Cardiodynamic Effects of the S1P1 Receptor Modulator Ponesimod Using a Novel Up‐Titration Regimen (2016)

Ponesimod, a potent selective sphingosine-1-phosphate receptor 1 modulator, leads to a reduction in circulating total lymphocyte count and transient decreases in heart rate (HR). Based on a modeling and simulation approach, this study was conducted to investigate whether a gradual up-titration regimen may mitigate these cardiodynamic effects. In this double-blind, placebo-controlled, randomized, 2-way crossover study, 32 healthy participants (15 males) received placebo on day 1 followed by multiple-dose administration of either ponesimod or placebo (ratio 3:1). Ponesimod was administered alternately using regimen A (incremental dose increase from 2 to 20 mg in 9 steps) or B (10 mg for 7 days followed by a single-dose administration of 20 mg). Cardiodynamic (Holter and 12-lead ECG), pharmacokinetic, pharmacodynamic (total lymphocyte count), and safety variables were assessed. After first-dose ponesimod administration (day 2), a transient decrease in HR was observed (nadir 2-3 hours postdose, back to predose values within 4-5 hours) of approximately 6 and 12 beats/min (bpm) (mean) following regimens A and B, respectively. On day 2, occurrence of HR <45 bpm, HR decrease from baseline of over 20 bpm, PR interval ≥200 milliseconds, or PR interval increase from baseline >20 ms, was lower following regimen A than B (14 vs 43 events). During the course of the study, incidence of HR <45 bpm was lower following regimen A than B (20 vs 58 events). Fewer participants reported adverse events following regimen A than B. Pharmacokinetics and pharmacodynamics were similar between the regimens. The novel gradual up-titration with ponesimod markedly mitigated initial cardiodynamic effects.
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3:  Synthesis of Fragment C15-21 (2003)

Smith's procedure of preparing fragment C15-21 (5) from common precursor 3 was optimized. The ease of plant operations made this six-step route successful for the production of several kilograms of this fragment with high purity.
Thermal conductivity reduction of crystalline silicon by high-pressure torsion (2014)

We report a dramatic and irreversible reduction in the lattice thermal conductivity of bulk crystalline silicon when subjected to intense plastic strain under a pressure of 24 GPa using high-pressure torsion (HPT). Thermal conductivity of the HPT-processed samples were measured using picosecond time domain thermoreflectance. Thermal conductivity measurements show that the HPT-processed samples have a lattice thermal conductivity reduction by a factor of approximately 20 (from intrinsic single crystalline value of 142 Wm(-1) K(-1) to approximately 7.6 Wm(-1) K(-1)). Thermal conductivity reduction in HPT-processed silicon is attributed to the formation of nanograin boundaries and metastable Si-III/XII phases which act as phonon scattering sites, and because of a large density of lattice defects introduced by HPT processing. Annealing the samples at 873 K increases the thermal conductivity due to the reduction in the density of secondary phases and lattice defects.
Statistical analysis of multiple access interference in Rayleigh fading environment for MIMO CDMA systems (2014)

A major limiting factor in the performance of MIMO-CDMA systems is multiple access interference (MAI) which can reduce the system capacity as well as bit error rate (BER). Thus, statistical characterization of MAI is vital in analyzing the performance of such systems. Since, the statistical analysis of MAI in MIMO-CDMA is quite involved especially in the presence of fading channels, existing works in literature employ suboptimal approaches to detect the subscriber without involving the need for MAI statistics such as successive interference cancellation (SIC) and parallel interference cancellation (PIC). To date, the exact characterization of multiple access interference in MIMO-CDMA is an unsolved problem. In this paper, we derive the expressions for the probability density function of MAI and MAI plus noise in MIMO-CDMA systems in the presence of both Rayleigh fading channels and additive Gaussian noise. Simulation results show that the theoretical predictions are very well substantiated.
Analyzing Software Specifications for Mode Confusion Potential (1998)

Increased automation in complex systems has led to changes in the human controller&amp;apos;s role and to new types of technology-induced human error. Attempts to mitigate these errors have primarily involved giving more authority to the automation, enhancing operator training, or changing the interface. While these responses may be reasonable under many circumstances, an alternative is to redesign the automation in ways that do not reduce necessary or desirable functionality or to change functionality where the tradeoffs are judged to be acceptable. This paper describes an approach to detecting error-prone automation features early in the development process while significant changes can still be made to the conceptual design of the system. The information about such error-prone features can also be useful in the design of the operator interface, operational procedures, or operator training. Introduction Today&amp;apos;s large, complex systems often incorporate both human and automated control and mon...
Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib (2014)

We have identified two novel ALK mutations arising after alectinib exposure that are sensitive to other next-generation ALK-TKIs. The ability of ceritinib to overcome alectinib-resistance mutations suggests a potential role for sequential therapy with multiple next-generation ALK-TKIs.
Evaluation and Comparison of Alternative Compliant Over-Running Clutch Designs (1999)

Abstract Compliance criteria is used to evaluate the general class of over-running clutches to determine which type is best suited to benefit from compliance. The criteria used in the evaluation include the presence and amount of revolution of revolute joints, the possibility for part count reduction, the presence of springs, possible reduction in weight, and the method of clutch engagement. The ratchet and pawl type of over-running clutch was shown to be the most promising. Within this type of over-running clutch, different designs incorporating bending, tension, and compression loading of the pawls were explored to determine the best method for loading the pawls. The clutches were compared using a ratio of the maximum output torque to over-running torque. It was determined that the clutch incorporating rigid pawls loaded in compression produced the largest ratio of output torque to over-running torque. The maximum output torque for this clutch was measured at 65.6 N-m and the over-running torque was measured at 0.011 N-m yielding a ratio of 5964.
ICONE23-1179 DEVELOPMENT OF INSTRUMENTATION SYSTEMS FOR SEVERE ACCIDENTS : 2. ACCIDENT TOLERANT INSTRUMENTATION FOR REACTOR-WATER LEVEL, HYDROGEN CONCENTRATION, PCV WATER LEVEL AND CONTAINMENT ATMOSPHERIC MONITORING (2015)

The accident at Tokyo Electric Power Company's Fukushima Dai-ichi Nuclear Power Plant (TF-1 accident) caused severe situations and resulted in a difficulty in measuring important parameters for monitoring plant conditions. Therefore, we have studied the TF-1 accident to select the important parameters that should be monitored at the severe accident (SA parameters) and are developing the Severe Accident Instrumentations and Monitoring Systems (SA-keisou) that could measure the parameters in severe accident conditions. For an example, reactor water level was selected as one of the SA parameters. The reactor water level is considered to be one of the most important parameters for reactor operators to understand the status of the reactor-core fuel. A new reactor water-level instrument was developed that complements the existing differential pressure method. The instrument is essentially a simple gamma thermometer which consists of several differential thermocouples and a heater. The gamma thermometer had been developed to monitor the in-core gamma-ray distribution, can be installed in the in-core housing, and measures the reactor water level by using the difference of the thermal conductivity of water and the air. This water-level instrument can measure the water-level condition of cooling reactor-core fuel. The instrument was manufactured, was verified at a testing facility, and the feasibility was confirmed. Another selected SA parameter was the hydrogen concentration in the primary containment vessel (PCV). An instrument that measures electric resistance of palladium was developed to monitor hydrogen concentration. In principle, the resistance of palladium increases with hydrogen absorption. The resistance of palladium is almost independent of vapor, whereas the temperature shift of resistance requires to be corrected. Platinum resistance was used for the correction: the hydrogen sensor consisted of palladium and platinum wires and is assembled in double spirals. This instrument was tested in our facility where its specification was confirmed. Also, the PCV water-level instrument and the Containment Atmospheric Monitoring System (ion chamber) were developed for the severe accident.
Abstract 11698: Endothelial Function Measured by Enclosed Zone Flow-mediated Vasodilation Predicts Cardiovascular Events (2017)

Introduction: We developed a new device for automatic measurement of flow-mediated vasodilation (FMD) using an oscillometric method to solve technical problems of conventional FMD measurement. The ...
ChemInform Abstract: Tandem Oxidative Cyclization with Rhenium Oxide. Total Synthesis of 17,18‐bisepi‐Goniocin. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Secure Scan and Test Using Obfuscation Throughout Supply Chain (2017)

Scan-based test is commonly used to increase testability and fault coverage, however, it is also known to be a liability for chip security. Research has shown that intellectual property (IP) or secret keys can be leaked through scan-based attacks, which can be performed by entities within the supply chain. In this paper, we propose a design and test methodology against scan-based attacks throughout the supply chain, which includes a dynamically obfuscated scan (DOS) for protecting IP/integrated circuits (ICs). By perturbing test patterns/responses and protecting the Obfuscation Key, the proposed architecture is proven to be robust against existing noninvasive scan-based attacks, and can protect all scan data from attackers in foundry, assembly, and system development without compromising the testability. Further, a novel test methodology cooperating with the DOS design is also proposed, which shows full pattern application flexibility. Finally, detailed security and experimental analyses have been performed on ITC and industrial benchmarks. Demonstrated by the simulation results, the proposed architecture can be easily plugged into EDA generated scan chains without generating a noticeable impact on conventional IC design, manufacturing, and test flow. The results demonstrate that the proposed methodology can protect chips from existing brute force, differential, and other scan-based attacks that target the Obfuscation Key. Furthermore, the proposed design is of low overhead on area, power consumption, and pattern generation time, and there is no impact on test time.
Search for a W′ or Techni-ρ Decaying into WZ in pp Collisions at √s=7 TeV (2012)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Eliminating all bad Local Minima from Loss Landscapes without even adding an Extra Unit (2019)

Recent work has noted that all bad local minima can be removed from neural network loss landscapes, by adding a single unit with a particular parameterization. We show that the core technique from these papers can be used to remove all bad local minima from any loss landscape, so long as the global minimum has a loss of zero. This procedure does not require the addition of auxiliary units, or even that the loss be associated with a neural network. The method of action involves all bad local minima being converted into bad (non-local) minima at infinity in terms of auxiliary parameters.
Energy-Efficient APM Using High Performance Batteries (2009)

Mitsubishi Heavy Industries (MHI) is taking the lead and pioneering the transit industry in green technology implementation by developing more environmentally friendly transit solutions and advantages to customers. MHI is currently developing a battery-powered transportation system. The use of high-performance, high-capacity batteries will not only improve electrical power efficiency but also contribute to simplified guideway equipment, improved safety and reduced operation and maintenance activities. This paper describes MHI's next generation energy-efficient APM using High Performance Batteries.
Single-Shot Analysis of Refractive Shape Using Convolutional Neural Networks (2019)

The appearance of a transparent object is determined by a combination of refraction and reflection, as governed by a complex function of its shape as well as the surrounding environment. Prior works on 3D reconstruction have largely ignored transparent objects due to this challenge, yet they occur frequently in real-world scenes. This paper presents an approach to estimate depths and normals for transparent objects using a single image acquired under a distant but otherwise arbitrary environment map. In particular, we use a deep convolutional neural network (CNN) for this task. Unlike opaque objects, it is challenging to acquire ground truth training data for refractive objects, thus, we propose to use a large-scale synthetic dataset. To accurately capture the image formation process, we use a physically-based renderer. We demonstrate that a CNN trained on our dataset learns to reconstruct shape and estimate segmentation boundaries for transparent objects using a single image, while also achieving generalization to real images at test time. In experiments, we extensively study the properties of our dataset and compare to baselines demonstrating its utility.