gebhart/patrepeval huggingface dataset:
Efficient Federated Learning Algorithm for Resource Allocation in Wireless IoT Networks (2020)

Federated learning (FL) allows multiple edge computing nodes to jointly build a shared learning model without having to transfer their raw data to a centralized server, thus reducing communication overhead. However, FL still faces a number of challenges such as nonindependent and identically distributed data and heterogeneity of user equipments (UEs). Enabling a large number of UEs to join the training process in every round raises a potential issue of the heavy global communication burden. To address these issues, we generalize the current state-of-the-art federated averaging (FedAvg) by adding a weight-based proximal term to the local loss function. The proposed FL algorithm runs stochastic gradient descent in parallel on a sampled subset of the total UEs with replacement during each global round. We provide a convergence upper bound characterizing the tradeoff between convergence rate and global rounds, showing that a small number of active UEs per round still guarantees convergence. Next, we employ the proposed FL algorithm in wireless Internet-of-Things (IoT) networks to minimize either total energy consumption or completion time of FL, where a simple yet efficient path-following algorithm is developed for its solutions. Finally, numerical results on unbalanced data sets are provided to demonstrate the performance improvement and robustness on the convergence rate of the proposed FL algorithm over FedAvg. They also reveal that the proposed algorithm requires much less training time and energy consumption than the FL algorithm with full user participation. These observations advocate the proposed FL algorithm for a paradigm shift in bandwidth-constrained learning wireless IoT networks.
Investigation of a parametric gain approach to single-channel speech enhancement (2015)

This paper investigates a parametric gain approach to single-channel noise reduction in the frequency domain. In comparison with the traditional parametric Wiener gain, the major novelty of this presented approach is that the parametric gain is formulated to estimate the noise by using the mean-squared error (MSE) between the noise and the noise estimate. The enhanced signal is then obtained by subtracting the noise estimate from the noisy observation signal. We show that this new method is more practical to implement and can produce better noise reduction performance as compared to the traditional parametric Wiener filtering techniques if the order of the parametric gain is not equal to 1. If the order is 1, the parametric gain is similar to the traditional Wiener gain. Simulation results are presented to illustrate the properties of this new approach.
A Microresonator Design Based on Nonlinear 1 : 2 Internal Resonance in Flexural Structural Modes (2009)

A unique T-beam microresonator designed to operate on the principle of nonlinear modal interactions due to 1 : 2 internal resonance is introduced. Specifically, the T-structure is designed to have two flexural modes with natural frequencies in a 1 : 2 ratio, and the higher frequency mode autoparametrically excites the lower frequency mode through inertial quadratic nonlinearities. A Lagrangian formulation is used to model the electrostatically actuated T-beam resonator, and it includes inertial quadratic nonlinearities, cubic nonlinearities due to midplane stretching and curvature of the beam, electrostatic potential, and effects of thermal prestress. A nonlinear two-mode reduced-order model is derived using linear structural modes in desired internal resonance. The model is used to estimate static pull-in bias voltages and dynamic responses using asymptotic averaging. Nonlinear frequency responses are developed for the case of resonant actuation of a higher frequency mode. It is shown that the lower frequency flexural mode is excited for actuation levels above a certain threshold and generates response component at half the frequency of resonant actuation. The effects of damping, thermal prestress, and mass and geometric perturbations from nominal design are thoroughly discussed. Finally, experimental results for a macroscale T-beam structure are briefly described and qualitatively confirm the basic analytical predictions. The T-beam resonator shows a high sensitivity to mass perturbations and, thus, holds great potential as a radio frequency filter-mixer and mass sensor.
Fas/Cd95 Pathway Induces Mouse Liver Regeneration and Allows for Highly Efficient Retrovirus–Mediated Gene Transfer (2001)

Stable gene transfer into hepatocytes has been proposed to compensate for genetic deficiencies that affect liver function, or to deliver diffusible factors into the circulation. This strategy can be achieved using retroviral vectors; however, cell division must occur. We describe a simple and reproductive method that enables the induction of hepatocyte replication in a controlled fashion, thus allowing an efficient in vivo retroviral liver transduction that is applicable to mouse models of human genetic disorders. The approach is based on liver susceptibility to apoptosis via the Fas/CD95 pathway. We show that, 4 days following a single Fas agonist antibody (JO2) injection, hepatocyte replication occurs, the intensity of which is correlated with the level of the induced hepatic cytolysis. This treatment enables in vivo liver transduction, and its efficiency also correlates with the level of hepatic cytolysis. When recombinant retroviral vectors were infused intravenously during the period of hepatocyte replication, 15.4% +/- 1.7% of the hepatocytes were transduced, reaching up to 32.5%.
Administration of the Mitochondrial Permeability Transition Pore Inhibitor, TRO40303, prior to Primary Percutaneous Coronary Intervention, Does Not Affect the Levels of Pro-Inflammatory Cytokines or Acute-Phase Proteins (2017)

The administration of the mPTP, TRO40303, prior to reperfusion does not alter the pharmacokinetics of pro-inflammatory cytokines or acute-phase proteins during the first 72 h after PCI.
Novel Nucleotide Phosphonate Analogues with Potent Antitumor Activity. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Antitumor Activity of β-Cyclodextrin Polymer−Camptothecin Conjugates (2004)

Antitumor activity of linear, beta-cyclodextrin polymer (CDP)-camptothecin (CPT) conjugates (HGGG6, LGGG10, HG6, and HGGG10) is investigated in nude mice bearing human LS174T colon carcinoma tumors. These conjugates differ in polymer molecular mass [97 kDa (H) or 35 kDa (L)], CDP-CPT linker structure [glycine (G) or triglycine (GGG)], and CPT loading [ca. 6 wt % (6) or 10 wt % (10)]. Maximum tolerable doses (MTDs) of the three conjugates, LGGG10, HG6, and HGGG10, are determined to be 36, 9, and 9 mg of CPT/kg, respectively, while the MTD of the CDP alone exceeds 240 mg/kg (highest value investigated). The three CDP-CPT conjugates with high polymer molecular masses (HGGG6, HG6, and HGGG10) demonstrate antitumor activity at their MTDs superior to that of CPT at the same amount and to that of irinotecan at its optimal dose. They also show tumor growth inhibition that is superior to that of the conjugate containing the low-molecular mass polymer (LGGG10) at the same dose of CPT. No significant effects of CPT weight loading or linker structure on tumor growth delay are observed. However, conjugates containing G appear to be less toxic than these with GGG. These antitumor studies demonstrate that the CDP-based conjugates of CPT exhibit tumor growth inhibition superior to that of CPT or irinotecan at the conditions employed in this study. The striking observation is that a short course of treatment with the polymer conjugates gives long-term control of tumor growth that does not occur with either CPT or irinotecan. Intracellular CDPs are demonstrated by analyzing cells that were cultured in the presence of rhodamine-labeled CDP (HRhod) containing medium using both confocal microscopy and flow cytometry. The long-term therapeutic efficacy of CDP-CPT conjugates observed in mice may in part be due to the sustained release of CPT from these conjugates in the acidic, intracellular compartments since these conjugates are shown to have significantly slower release rates at acidic pH than at physiological pH.
First-Order PMD Outage Prediction Based on Outage Maps (2010)

We compare the applicability of different methods for the calculation of first order polarization-mode dispersion (PMD) outage probabilities under the Maxwellian probability density assumption for the differential group delay. Results based on measured outage maps are contrasted with outage predictions using various simplifying approximations. We present a comprehensive data set of measured PMD outage maps at 10.7 Gb/s using non return-to-zero and return-to-zero on-off keying in combination with both standard threshold detection and maximum likelihood sequence estimation, with and without residual chromatic dispersion.
Learning contrastive connectives in sentence realization ranking (2008)

We look at the average frequency of contrastive connectives in the SPaRKy Restaurant Corpus with respect to realization ratings by human judges. We implement a discriminative n-gram ranker to model these ratings and analyze the resulting n-gram weights to determine if our ranker learns this distribution. Surprisingly, our ranker learns to avoid contrastive connectives. We look at possible explanations for this distribution, and recommend improvements to both the generator and ranker of the sentence plans/realizations.
Invited: Circuit scaling limits for ultra-large-scale integration (1981)

This report will define a hierarchy of limits governing ULSI and describe circuit performance to project minimum dimensions for NMOS transistors, polysilicon resistors and interconnections. Possible future levels of ULSI will also be assessed.
Technology/System Codesign and Benchmarking for Lateral and Vertical GAA Nanowire FETs at 5-nm Technology Node (2015)

For sub-7-nm technology nodes, the gate-all-around (GAA) nanowire-based device structure is a strong candidate to sustain scaling according to Moore's Law. For the first time, the performance of two GAA device options- lateral FET (LFET) and vertical FET (VFET)-is benchmarked and analyzed at the system level using an ARM core processor, based on realistic compact device models at the 5-nm technology node. Tradeoffs among energy, frequency, leakage, and area are evaluated by a multi-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> optimization flow. A variety of relevant device configurations, including various number of fins, nanowires, and nanowire stacks, are explored. The results demonstrate that an LFET GAA core has a larger maximum frequency than its VFET counterpart because the channel stress that can be created in the LFETs results in a larger ON current. For fast timing targets, the LFET cores are therefore superior. However, for slow timing targets (e.g., 5 ns), the VFET cores with three nanowires offer a 7% area reduction and a 20% energy saving compared with the LFET cores with 2fin/2stack at the same leakage power.
MRI: ID-Development of a Hybrid Scanning Fluorescence and Sum Frequency Spectroscopy Imaging Microscope (2011)

With this award from the Major Research Instrumentation program (MRI), Michael Mason and colleagues from the Department of Chemistry at the University of Maine will develop a hybrid scanning fluorescence (FL) and sum frequency (SF) spectroscopy imaging microscope. The instrument will be constructed by the addition of sample scanning and FL capability to an existing broadband SF spectrometer. The SF NIR pump source will be used to excite SF at the sample interface, while a modulated Argon ion CW laser will excite FL. These collinear sources will give rise to spatially and temporally correlated SF and FL signals which will be separated and individually detected. The instrument will simultaneously measure the fluorescence and sum frequency to yield information about the localized dynamics of a single particle, i.e. protein, and spatially correlated structural information about the bulk material containing the particle. This yields information about the interaction between the particle and the bulk not accessible by any other method. The proposal will initially investigate test projects including the study of membrane domain structure and membrane-membrane interactions, e,g., correlation of the structure and dynamics of lipid and protein molecules within planar supported lipid bilayers. Successful development of this instrument could lead to major breakthroughs in several fields ranging from surface chemistry and biophysics to nanotechnology and cellular biology.
Modeling of the bulk versus SOI CMOS performances for the optimal design of APS circuits in low-power low-voltage applications (2003)

In this paper, we present the top-down design of an active pixel sensor (APS) circuit using an analytical model of its architecture. The model is applied to compare the performances of bulk versus silicon-on-insulator (SOI) CMOS processes and devices on the designs and performance of several 50-frames/s imagers in 2-/spl mu/m and 0.25-/spl mu/m CMOS with different pixels array sizes. For 2-/spl mu/m SOI, results show a reduction by two of the power consumption and a dynamic range increase of 0.85 V under a 3-V supply. This results in an SNR of 79 dB instead of 76. Fixed pattern noise (FPN) is also reduced from 2.7 to 1.8 mV which represents 0.26% and 0.08% of the dynamic range, respectively. For 0.25-/spl mu/m CMOS SOI, results show a reduction by 6.5 of the power consumption, FPN more than five time better, and a dynamic range increase of 0.29 V under a 1.5-V supply. However, because of the increase of the thermal noise due to the particular design choice, an SNR of 60.3 dB is achieved compared to 63 in bulk. A better SNR in SOI than in bulk can be achieved but at the expense of power consumption and FPN. However, this could be combined with an increase in pixels number in SOI compared to bulk. Potential results achievable in SOI have to our knowledge never been reached by bulk APS imagers up to now.
Development of a nasal cast model to test medicinal nasal devices (2008)

Bespak, a division of Consort Medical plc, and Queen's University Belfast have developed a viable and unique in-vitro testing capability for nasal drug delivery devices. The aim was to evaluate and optimize current and conceptual drug delivery devices by quantifying the deposition of drug in the various distinct regions of the nasal cavity. The development of this test apparatus employed computed tomography (CT) scan data of the human nasal cavity to construct an accurate representation of the human nasal airways. An investigation of suitable materials and manufacturing technologies was required, together with extensive analytical method development. It is possible for this technique to be further developed in an attempt to create a standardized apparatus based on nasal geometry that can be used to compare accurately deposition from drug delivery devices. This paper presents the issues encountered in the development of this test apparatus, including manufacturing and material limitations, investigation and choice of suitable materials, laboratory testing considerations, and the steps required to validate the analytical process.
Enhanced Wide-band Infrared Absorptivity of Black Silicon (2020)

Infrared radiative properties of materials are of fundamental significance for several applications involving thermal radiation conversion and management such as sensors, thermo-photovoltaics, thermal rectification, thermal memories, thermal logical circuits and radiative cooling[1], subsequently, attracting an increased attention in recent years [2]. In the present work, we report, on the exceptionally high absorptivity of Black Silicon (BSi) in the spectral range of thermal radiation, which can be instrumental for various thermal radiation related applications. Black Silicon (BSi) is a bottom-up nano-structured silicon surface that can be obtained by different techniques [3] including wafer-level cryogenic plasma etching [4]. It is well known since [5] that such nano-scale features lead to a significant enhancement of silicon absorptivity in the visible range [4]. Having previously shown [6][7] that we can extend such outstanding properties to the mid-infrared (MIR) by using highly doped silicon, in this work we report that the high absorptivity in fact further hinges on to the far-infrared(FIR) range. Having fabricated two wafers of BSi having n-type doping of 2x1018 cm-3 (standard doping) and 4.5x1019 cm-3 (high doping), we have found experimentally and confirmed by electromagnetic numerical simulations that for highly doped BSi, a high absorptivity is observed till 15~$\unit{\mu m}$ which has also been compared with similarly doped Flat Si(FSi) samples. However, beyond 15~$\unit{\mu m}$, the absorptivity of highly doped BSi sample shows a growing tendency to decrease. Subsequent processing of SEM images reveals that these noteworthy radiative properties can probably be attributed to particular morphological features of heavily doped BSi at the nano-scale. \footnotesize{ \noindent ~[1] Ko, B et. al., Energies, no.12, p. 89, 2019. \noindent ~[2] E. Rephaeli et. al., Nano Lett., no. 13, p. 1457, 2013. \noindent ~[3] M. Steglich et al., Laser \&amp; Photonics Reviews, vol. 8, no. 2, pp. L13–L17, 2014. \noindent ~[4] D. A. Saab et al., Physical review letters, vol. 113, no. 26, p. 265502, 2014. \noindent ~[5] K. N. Nguyen et al., Journal of Applied Physics, vol. 113, no. 19, p. 19490. \noindent ~[6] S. Sarkar, et al., 32nd International Conference on Micro Electromechanical Systems (MEMS), IEEE, 2019. \noindent ~[7] S. Sarkar, et al., 25th International Workshop on Thermal Investigation of ICs and Systems (THERMINIC 2019).}
Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration (2007)

In the majority of neurodegenerative storage disorders, neuronal death in the brain is followed by infiltration of phagocytic cells (e.g. activated microglia, astroglia and macrophages) for the efficient removal of cell corpses. However, it is increasingly evident that these phagocytes may also cause death of adjoining viable neurons contributing to rapid progression of neurodegeneration. Infantile neuronal ceroid lipofuscinosis (INCL) is a devastating, neurodegenerative, lysosomal storage disorder caused by inactivating mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. PPT1 catalyzes the cleavage of thioester linkages in S-acylated (palmitoylated) proteins and its deficiency leads to abnormal accumulation of thioesterified polypeptides (ceroid) in lysosomes causing INCL pathogenesis. PPT1-knockout (PPT1-KO) mice mimic the clinical and pathological features of human INCL including rapid neuronal death by apoptosis and phagocyte infiltration. We previously reported that in PPT1-KO mice, the neurons undergo endoplasmic reticulum stress activating unfolded protein response, which mediates caspase-12 activation and apoptosis. However, the molecular mechanism(s) by which the phagocytic cells are recruited in the PPT1-KO mouse brain remains poorly understood. We report here that increased production of lysophosphatidylcholine (LPC), catalyzed by the activation of cytosolic phospholipase A(2) (cPLA(2)) in the PPT1-KO mouse brain, is a 'lipid signal' for phagocyte recruitment. We also report that an age-dependent increase in LPC levels in the PPT1-KO mouse brain positively correlates with elevated expression of the genes characteristically associated with phagocytes. We propose that increased cPLA(2)-catalyzed LPC production in the brain is at least one of the mechanisms that mediate phagocyte infiltration contributing to INCL neuropathology.
Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma (2019)

Studies on the efficacy of small molecule inhibitors in Merkel cell carcinoma (MCC) have been limited and largely inconclusive. In this study, we investigated the therapeutic potential of a potent BET degrader, BETd-246, in the treatment of MCC. We found that MCC cell lines were significantly more sensitive to BETd-246 than to BET inhibitor treatment. Therapeutic targeting of BET proteins resulted in a loss of "MCC signature" genes but not MYC expression as previously described irrespective of Merkel cell polyomavirus (MCPyV) status. In MCPyV+ MCC cells, BETd-246 alone suppressed downstream targets in the MCPyV-LT Ag axis. We also found enrichment of HOX and cell cycle genes in MCPyV- MCC cell lines that were intrinsically resistant to BETd-246. Our findings uncover a requirement for BET proteins in maintaining MCC lineage identity and point to the potential utility of BET degraders for treating MCC.
Chitinase Inhibition Promotes Atherosclerosis in Hyperlipidemic Mice (2013)

Chitinase 1 (CHIT1) is secreted by activated macrophages. Chitinase activity is raised in atherosclerotic patient sera and is present in atherosclerotic plaque. However, the role of CHIT1 in atherosclerosis is unknown. Preliminary studies of atherosclerosis in cynomolgous monkeys revealed CHIT1 to be closely correlated with areas of macrophage infiltration. Thus, we investigated the effects of a chitinase inhibitor, allosamidin, on macrophage function in vitro and on atherosclerotic development in vivo. In RAW264.7 cells, allosamidin elevated monocyte chemoattractant protein 1 and tumor necrosis factor alpha expression, and increased activator protein 1 and nuclear factor-κB transcriptional activity. Although inducible nitric oxide synthase, IL-6, and IL-1β expression were increased, Arg1 expression was decreased by chitinase inhibition, suggesting that suppression of CHIT1 activity polarizes macrophages into a M1 phenotype. Allosamidin decreased scavenger receptor AI, CD36, ABCA1, and ABCG1 expression which led to suppression of cholesterol uptake and apolipoprotein AI-mediated cholesterol efflux in macrophages. These effects were confirmed with CHIT1 siRNA transfection and CHIT1 plasmid transfection experiments in primary macrophages. Apolipoprotein E-deficient hyperlipidemic mice treated for 6 weeks with constant administration of allosamidin and fed an atherogenic diet showed aggravated atherosclerotic lesion formation. These data suggest that CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages.
The Claremont report on database research (2009)

Database research is expanding, with major efforts in system architecture, new languages, cloud services, mobile and virtual worlds, and interplay between structure and text.