gebhart/patrepeval huggingface dataset:
Foreign Object Detection in Wireless Power Transfer Systems (2021)

The successful commercialization of wireless power transfer (WPT) technology in mobile phones, laptops, and electric vehicles requires a safe, reliable, and efficient charging infrastructure. A metal object, such as a coin, a key, or a nail, however, may be inadvertently exposed, by close proximity, to the magnetic fields generated by the WPT coupler, creating a potential safety hazard and affecting the electrical characteristics of the WPT system. In addition, the magnetic fields may produce adverse symptoms, such as dizziness and breathlessness, in living objects near the charging systems. This article provides a current state of the art review of all available designs for detecting metal and living objects in WPT systems. Working principles and qualitative comparisons in terms of sensitivity, accuracy, and cost of major detection methods are presented to reveal their inherent limitations and available applications. Finally, a number of research topics on foreign object detection are suggested to encourage more researchers to make contributions to the development and commercial application of wireless charging systems.
A Pilot Study Evaluating the CD34+ Cell Mobilizing Activity and Adverse Events Associated with Escalating Doses of AMD3100 in Healthy Volunteers. (2007)

Abstract Background: AMD3100 (AMD or plerixafor) inhibits the binding of SDF-1 to its cognate receptor CXCR4 resulting in the rapid mobilization of CD34+ hematopoietic progenitor cells into the peripheral circulation. A prior phase I study suggested peak CD34+ cell mobilization occurred 6–8 hours following a 240 mcg/kg dose of AMD. This investigation provides preliminary data on the safety and CD34+ cell mobilizing effects of doses up to 480 mcg/kg of AMD. Methods: To account for inter-subject variability, subjects in three cohorts received two different subcutaneous doses of AMD. Healthy volunteers received the following doses of AMD: 240 mcg/kg and 320 mcg/kg (cohort 1); 320 mcg/kg and 400 mcg/kg (cohort 2); and 400 mcg/kg and 480 mcg/kg (cohort 3). Subjects received the higher dose at least 14 days after the first to allow adequate wash-out of AMD. The absolute number of circulating CD34+ cells were measured after each dose at the following times: 0, 2, 4, 6, 8, 10, 12, 14, 18, and 24 hours. In addition, this study assessed the following parameters: adverse events, AMD pharmacokinetics (400 and 480 mcg/kg doses), cytokine polarization status (Th1 vs Th2) of AMD mobilized CD3+ T-cells, and endothelial progenitor cell measurements. Results: To date, 16 of the planned 18 subjects have been enrolled on study with final results available for the first two cohorts; preliminary results exist for four subjects in the third cohort (400 mcg/kg vs 480 mcg/kg dose). Common toxicities include diarrhea, nausea, sinus tachycardia, injection site redness, perioral paresthesias, and headache. No dose limiting toxicities were observed; however, the frequency and/or magnitude of headache, nausea, vomiting, diarrhea, and tachycardia were greater at the 400 mcg/kg dose. Table 1 summarizes the preliminary CD34+ mobilization results for the 240, 320, and 400 mcg/kg doses. The lines in figures 1 and 2 show the difference in an individual subjects peak CD34+ cell number mobilized following 2 different doses of AMD. Conclusion: Although this phase I study is ongoing, preliminary data suggest doses of AMD higher than 240 mcg/kg may improve the peak numbers of CD34+ cells mobilized into the circulation. Furthermore, although dose escalation continues, the adverse events observed after a 400 mcg/kg dose of AMD appear similar to those observed after lower doses; no grade 3 or 4 adverse events have been observed. The final study results will provide additional data on the dose of AMD that optimizes CD34+ cell and CFU-GM mobilization for both autologous and allogeneic hematopoietic stem cell collections. CD 34+ cell mobilization 240 mcg/kg 320 mcg/kg 400 mcg/kg *Two subjects in 400 mcg dose group had the same peak mobilization time at two time points: these were averaged Number of subjects 6 12 10 Mean mobilized CD34 cells/microliter 27 29 31 Standard deviation of CD34 cells/microliter 13 14 13 Average peak mobilization time in hours* 9 10 11 Range of peak mobilization times in hours 8−14 6−14 8−18 Figure Figure
Specificity of regulatory CD4+CD25+ T cells for self‐T cell receptor determinants (2004)

Although the phenotypic and regulatory properties of the CD4(+)CD25(+) T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4(+)CD25(+) Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoire as well as that of a clonotypic nongermline-encoded CDR3beta sequence present in a recombinant soluble T cell receptor (TCR) protein. Regulatory activity was demonstrated in T cell lines responsive to TCR but not in T cell lines responsive to control antigens. Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants.
ChemInform Abstract: Adenosine Derivatives as Agonists of Adenosine Receptors (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The genome ofTreponema pallidum: new light on the agent of syphilis (1998)

Treponema pallidum subsp. pallidum, the causative agent of the sexually transmitted disease syphilis, is a fastidious, microaerophilic obligate parasite of humans. This bacterium is one of the few prominent infectious agents that has not been cultured continuously in vitro and consequently relatively little is known about its virulence mechanisms at the molecular level. T. pallidum therefore represented an attractive candidate for genomic sequencing. The complete genome sequence of T. pallidum has now been completed and comprises 1 138 006 base pairs containing 1041 predicted protein coding sequences. An important goal of this project is to identify possible virulence factors. Analysis of the genome indicates a number of potential virulence factors including a family of 12 proteins related to the Msp protein of Treponema denticola, a number of putative hemolysins, as well as several other classes of proteins of interest. The results of this analysis are reviewed in this article and indicate the value of whole genome sequences for rapidly advancing knowledge of infectious agents.
Data Center Challenges and Their Power Electronics (2017)

Data centers use more than 1.5% of all electricity in China and the U.S., with continuing growth. This paper reviews the power hierarchy levels within modern data centers. It considers energy consumption and power electronics challenges across all levels of a data center, including building distribution, dc architectures, and conversion down to the board level. Power electronics plays a central role throughout the hierarchy, and emerging approaches are described. Strategies that enhance center energy efficiency, both in terms of overall center operation and in terms of computation performance, are discussed.
Cover Picture: Plasma Process. Polym. 9/2019 (2019)

Front Cover: The ability to control individual step parameters in cyclic plasma etch processes provides novel capabilities for nanofabrication. In this example, the pitch of a line/space array is halved as the pattern is transferred into a tantalum nitride (TaN) film. The redeposition of a partially oxidized surface layer creates a self-aligned mask, and line edge roughness (LER) is maintained by the highly selective nature of the etch. Further details can be found in the article by Nathan Marchack, Keith Hernandez, Benjamin Walusiak, Jon-l Innocent-Dolor, Sebastian Engelmann (1900008).
Conception théorique d'un nouveau modulateur électrooptique sur GaAs/AlGaAs à largeur de bande commandée en tension (1987)

Dans cet article, nous présentons un nouveau type de modulateur électrooptique à onde progressive. L'originalité de ce nouveau composant réside dans l'adjonction d'une tension de commande extérieure qui a pour rôle d'accorder l'indice microonde à l'indice optique : le résultat est un élargissement considérable de la largeur de bande de modulation.
18.3: Low Power 3.4inch Quarter High Definition OLED Display Using InGaZnOxide TFTs and White Tandem OLED (2010)

Abstract We recently succeeded in manufacturing a 3.4 inch QHD OLED display 326ppi with high aperture ratio, 40%, in which we adopted the white OLED using a tandem structure and a color filter method. Besides, we achieved 40% lower the power consumption of the driver circuit 60mW by improving it.
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer (2020)

Epigenetic changes are increasingly being appreciated as key events in breast cancer progression. However, breast cancer subtype-specific epigenetic regulation remains poorly investigated. Here we report that EZH2 is a leading candidate of epigenetic modulators associated with the TNBC subtype and that it predicts poor overall survival in TNBC patients. We demonstrate that specific pharmacological or genetic inhibition of EZH2 catalytic activity impairs distant metastasis. We further define a specific EZH2<sup>high</sup> population with enhanced invasion, mammosphere formation, and metastatic potential that exhibits marked sensitivity to EZH2 inhibition. Mechanistically, EZH2 inhibition differentiates EZH2<sup>high</sup> basal cells to a luminal-like phenotype by derepressing GATA3 and renders them sensitive to endocrine therapy. Furthermore, dissection of human TNBC heterogeneity shows that EZH2<sup>high</sup> basal-like 1 and mesenchymal subtypes have exquisite sensitivity to EZH2 inhibition compared with the EZH2<sup>low</sup> luminal androgen receptor subtype. These preclinical findings provide a rationale for clinical development of EZH2 as a targeted therapy against TNBC metastasis.
A Brief Tutorial on Mixed Signal Approaches to Combat Electronic Counterfeiting (2023)

As integrated circuit (IC) designs become more and more complex, the globalization of the IC supply chain has become inevitable. Because multiple entities are required to design, fabricate, test, and distribute an IC, the need for reliable security and assurance methods to maintain trust throughout the entire supply chain has never been more critical. This tutorial introduces a variety of mixed-signal approaches to combat electronic counterfeiting. An LDO-based odometer capable of accurately classifying ICs as new or aged is presented as a promising method for detecting counterfeit and recycled ICs. Additionally, this tutorial discusses the use of physical unclonable functions (PUFs) as primitives for generating cryptographic keys for digital signatures, encryption, or authentication. The design process of all PUFs is introduced and the key characteristics and evaluation metrics of state-of-the-art PUFs are defined. Finally, to promote digital IP protection, several methods for camouflaged digital gates are presented and analyzed. The threshold voltage defined (TVD) logic families discussed are capable of implementing any N-to-1 logic function and are highly resilient to reverse engineering attacks.
Negative regulation of biofilm development by the CUG‐Ser1 clade‐specific histone H3 variant is dependent on the canonical histone chaperone CAF‐1 complex in Candida albicans (2023)

The CUG-Ser1 clade-specific histone H3 variant (H3V<sup>CTG</sup> ) has been reported to be a negative regulator of planktonic to biofilm growth transition in Candida albicans. The preferential binding of H3V<sup>CTG</sup> at the biofilm gene promoters makes chromatin repressive for the biofilm mode of growth. The two evolutionarily conserved chaperone complexes involved in incorporating histone H3 are CAF-1 and HIRA. In this study, we sought to identify the chaperone complex(es) involved in loading H3V<sup>CTG</sup> . We demonstrate that C. albicans cells lacking either Cac1 or Cac2 subunit of the CAF-1 chaperone complex, exhibit a hyper-filamentation phenotype on solid surfaces and form more robust biofilms than wild-type cells, thereby mimicking the phenotype of the H3V<sup>CTG</sup> null mutant. None of the subunits of the HIRA chaperone complex shows any significant difference in biofilm growth as compared to the wild type. The occupancy of H3V<sup>CTG</sup> is found to be significantly reduced at the promoters of biofilm genes in the absence of CAF-1 subunits. Hence, we provide evidence that CAF-1, a chaperone known to load canonical histone H3 in mammalian cells, is involved in chaperoning of variant histone H3V<sup>CTG</sup> at the biofilm gene promoters in C. albicans. Our findings also illustrate the acquisition of an unconventional role of the CAF-1 chaperone complex in morphogenesis in C. albicans.
Genetic organization and transcriptional regulation in the qa gene cluster of Neurospora crassa. (1981)

A transcription map of the qa gene cluster of Neurospora crassa has been constructed by using cloned DNA fragments as hybridization probes. The mRNAs encoded in the previously identified qa-2 (3-dehydroquinate hydro-lyase, EC 4.2.1.10), qa-4 (dehydroshikimate dehydratase), qa-3 (quinate:NAD+ 3-oxidoreductase, EC 1.1.1.24), and qa-1 (regulatory protein) genes have been characterized. In addition, mRNAs encoded in two new genes in this cluster (qa-x, qa-y) have been identified. Regulation of this system occurs at the level of transcription and is under the combined control of quinic acid and the qa-1 protein. The qa cluster represents a group of adjacent coding sequences which occupy approximately 18 kilobases in linkage group VII. The expression of the qa-1 gene appears to be constitutive but also autoregulated. mRNAs encoded in genes flanking the qa gene cluster have also been identified.
Plane Wave Coupling to a Transmission Line Above Ground with Terminating Loads (2019)

This paper considers plane wave coupling to a transmission line consisting of an aerial wire above a conducting ground. Simple circuit models are constructed for the terminating impedances at the ends of the line including radiation effects. We consider the following load topologies: open circuit, short circuit, and grounded rods. Results from the transmission line model with these loads show good agreement with full-wave simulations.&#x0D;
On-Chip Power Distribution Grids With Multiple Supply Voltages for High-Performance Integrated Circuits (2008)

On-chip power distribution grids with multiple supply voltages are discussed in this paper. Two types of interdigitated and paired power distribution grids with multiple supply voltages and multiple grounds are presented. Analytic models are also developed to estimate the loop inductance in four types of proposed power delivery schemes. Two proposed schemes, fully and pseudo-interdigitated power delivery, reduce power supply voltage drops as compared to conventional interdigitated power distribution systems with dual supplies and a single ground by, on average, 15.3% and 0.3%, respectively. The performance of the proposed on-chip power distribution grids is compared to a reference power distribution grid with a single supply and a single ground. The voltage drop in fully interdigitated and fully paired power distribution grids with multiple supplies and multiple grounds is reduced, on average, by 2.7% and 2.3%, respectively, as compared to the voltage drop of an interdigitated power distribution grid with a single supply and a single ground. The proposed power distribution grids are a better alternative to a single supply voltage and a single ground power distribution system. On-chip resonances in power distribution grids with decoupling capacitors are intuitively explained in this paper, and circuit design implications are provided. It is also noted that fully interdigitated and fully paired power distribution grids with multiple supply voltages and multiple grounds are recommended to decouple power supply voltages.
Reconstruction of the carbon sp2network in graphene oxide by low-temperature reaction with CO (2011)

Low-temperature (−176 °C) CO adsorption on graphene oxide and partially reduced graphene oxide sheets was investigated in a combined IR spectroscopic and DFT study. The reactivity of the carbon vacancies in the network was observed to be extremely high, causing the CO molecules to dissociate in a barrier-less process that leads to the reconstruction of the sp2graphene network. After the adsorption of CO on the graphene oxide materials, the intensity of the FTIR bands is lower in the case of partially reduced graphene oxide sheets, indicating that there are fewer active sites available for CO interaction.
Proactive Computation Caching Policies For 5G-and-Beyond Mobile Edge Cloud Networks (2018)

Computation caching is a novel strategy to improve the performance and the quality of service of mobile edge cloud networks. It consists in storing in local memories situated at the edge of the network, here mobile access points, the already processed results of computations that users offload to the mobile edge cloud. The goal of this technique is to avoid redundant and repetitive processing of the same tasks, thus streamlining the offloading process and improving the exploitation of both users' and network's resources. In this paper, three different computation caching policies are proposed and evaluated. They are based on three main parameters: the popularity of offloadable tasks, the size of their inputs, and the size of their results. Numerical simulations show that good policies need to take into account these three parameters altogether.
Assessment of the spatial resolution of PET scanners using a Geant4-based Monte Carlo tool (2004)

In this paper, the spatial resolution of PET scanners is assessed by means of a Geant4-based Monte Carlo tool. To obtain a high level of accuracy, all relevant contributions like /spl beta//sup +/ range and gamma noncollinearity, crystal size and material, intercrystal scatter, and scanner geometry are implemented in detail. For a system based on Anger logic, the scintillator light yield, the photon statistics and the PMT characteristics are also taken into account. In the simulation, Monte Carlo and analytical algorithms share a common setup, which allows for the necessary computation speed to generate clinical count statistics without compromising accuracy. In the first part, the major contributions to the spatial resolution are analyzed separately. The impact on the total system resolution is then illustrated by investigating three scanner designs with different gantry sizes, crystal sizes, crystal materials and /spl beta//sup +/ tracers.
Internal thrust and pumping performance of an auxiliary inlet ejector nozzle with clamshell thrust reverser (1969)

Simulated take-off, transonic acceleration, and supersonic flight conditions using auxiliary inlet ejector nozzle
The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target (2017)

Our data strongly suggest that inhibition of G. lamblia PDE activity leads to a profound inhibition of parasite proliferation and that GlPDE is a promising target for developing novel anti-giardial drugs.
Client Honeypot Multiplication with High Performance and Precise Detection (2015)

We investigated client honeypots for detecting and circumstantially analyzing drive-by download attacks. A client honeypot requires both improved inspection performance and in-depth analysis for inspecting and discovering malicious websites. However, OS overhead in recent client honeypot operation cannot be ignored when improving honeypot multiplication performance. We propose a client honeypot system that is a combination of multi-OS and multi-process honeypot approaches, and we implemented this system to evaluate its performance. The process sandbox mechanism, a security measure for our multi-process approach, provides a virtually isolated environment for each web browser. It prevents system alteration from a compromised browser process by I/O redirection of file/registry access. To solve the inconsistency problem of file/registry view by I/O redirection, our process sandbox mechanism enables the web browser and corresponding plug-ins to share a virtual system view. Therefore, it enables multiple processes to be run simultaneously without interference behavior of processes on a single OS. In a field trial, we confirmed that the use of our multi-process approach was three or more times faster than that of a single process, and our multi-OS approach linearly improved system performance according to the number of honeypot instances. In addition, our long-term investigation indicated that 72.3% of exploitations target browser-helper processes. If a honeypot restricts all process creation events, it cannot identify an exploitation targeting a browser-helper process. In contrast, our process sandbox mechanism permits the creation of browser-helper processes, so it can identify these types of exploitations without resulting in false negatives. Thus, our proposed system with these multiplication approaches improves performance efficiency and enables in-depth analysis on high interaction systems.
"Use of Refractive Index Matching Fluids in a Laser Based Detector for Capillary Chromatography" (1990)

The diffraction pattern from side illuminated capillary tubes has been exploited to develop a refractive index detector of universal character suitable for HPLC and CE. A two-fold benefit is obtained by surrounding the capillary with a RI matching fluid. The fringe pattern is simplified and thermal drift is reduced.
Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump (2007)

The role of cell membranes in regulating the flux of long chain free fatty acids (FFA) into and out of adipocytes is intensely debated. Four different membrane proteins including, FABPpm, CD36/FAT, caveolin-1, and FATP have been identified as facilitating FFA transport. Moreover, CD36 and caveolin-1 are also reported to mediate transport in conjunction with lipid rafts. The principal evidence for these findings is a correlation of the level of FFA uptake with the expression level of these proteins and with the integrity of lipid rafts. The 3T3-L1 and 3T3-F442A cell lines in their preadipocyte states reveal little or no expression of these proteins and correspondingly low levels of uptake. Here we have microinjected the adipocyte and preadipocyte cell lines with ADIFAB, the fluorescent indicator of FFA. The ADIFAB fluorescence allowed us to monitor the intracellular unbound FFA concentration during FFA influx and efflux. We show that these measurements of transport, in contrast to FFA uptake measurements, correlate neither with expression of these proteins nor with lipid raft integrity in preadipocytes and adipocytes. Transport characteristics, including the generation of an ATP-dependent FFA concentration gradient, are virtually identical in adipocytes and preadipocytes. We suggest that the origin of the discrepancy between uptake and our measurements is that most of the FFA transported into the cells is lost during the uptake but not in the transport protocols. We conclude that long chain fatty acid transport in adipocytes is very likely mediated by an as-yet-unidentified membrane protein pump.