gebhart/patrepeval huggingface dataset:
Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction (1993)

The zeta-subunit of the TCR binds GTP and is a well characterized substrate for a TCR-activated tyrosine kinase. To examine the possible coupling of GTP-binding to zeta with TCR-mediated signal transduction, a mutant (termed J32-3.2) of the T cell line Jurkat (J32) was used. Anti-TCR/CD3 stimulation of the TCR/CD3+ J32-3.2 cells resulted in a weak stimulation of both the phosphatidyl inositol and tyrosine kinase signal transduction pathways, as measured by changes in the level of free intracellular calcium, tyrosine phosphorylation of TCR-zeta, CD3-epsilon and ZAP-70, p56lck, or p59fyn tyrosine kinase activity and IL-2 gene activation. The impaired responsiveness of J32-3.2 cells to anti-TCR/CD3 mAb correlated with a low basal level of GTP-binding to zeta. Furthermore, in J32-3.2 cells TCR activation by antibody ligation caused a weaker increase in GTP-binding to the zeta-chain, as compared with that of wild-type J32 cells, which indicates for the first time that GTP-binding to zeta can be modulated by extracellular signals and suggest that the role of GTP-binding to zeta is to couple the TCR to intracellular signal transduction mechanisms.
Développement de composants optiques de grande taille pour laser multi-PW (2016)

National audience
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons (1998)

Drosophila melanogaster has proven to be a good model for understanding the physiology of ion channels. We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits. Expression of RPK generated multimeric Na+ channels that were dominantly activated by a mutation associated with neurodegeneration. Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels. Although PPK did not form channels on its own, it associated with and reduced the current generated by a related human brain Na+ channel. RPK transcripts were abundant in early stage embryos, suggesting a role in development. In contrast, PPK was found in sensory dendrites of a subset of peripheral neurons in late stage embryos and early larvae. In insects, such multiple dendritic neurons play key roles in touch sensation and proprioception and their morphology resembles human mechanosensory free nerve endings. These results suggest that PPK may be a channel subunit involved in mechanosensation.
Multi-Armed Bandit in Action: Optimizing Performance in Dynamic Hybrid Networks (2018)

Today's home networks are often composed of several technologies such as Wi-Fi or power-line communication (PLC). Yet, current network protocols rarely fully harness this diversity and use each technology for a specific, pre-defined role, for example, wired media as a backbone and the wireless medium for mobility. Moreover, a single path is generally employed to transmit data; this path is established in advance and remains in use as long as it is valid, although multiple possible paths offer more robustness against varying environments. We introduce HyMAB, an algorithm that explores different multipaths and finds the best one in a mesh hybrid network, while keeping congestion under control. We employ the multi-armed-bandit framework and prove that HyMAB achieves optimal throughput under a static scenario. HyMAB design also accounts for real-network intricacies and dynamic conditions; it adapts to varying environments and switches multipaths when needed. We implement HyMAB on a PLC/Wi-Fi test bed. This is, to the best of our knowledge, the first implementation on a real test bed of multi-armed-bandit strategies in the context of routing. Our experimental results confirm the optimality of HyMAB and its ability to adapt to dynamic network conditions, as well as the gains provided by employing multi-armed-bandit strategies.
Efficient support of hardware debugging through FPGA physical design partitioning (1999)

No abstract available.
A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer (2017)

Nanotechnology offers many possibilities to improve drug treatments, including with regard to drug pharmacology. The current study reports a simple approach to improve cisplatin efficacy in the treatment of colon cancer through the creation of orally administered squalenoylated nanoparticles loaded with cisplatin (SQ-CDDP NP). Cytotoxic effects of SQ-CDDP NP were assessed in human colonic cells and in mouse models of intestinal cancer. In cell culture, SQ-CDDP NP exhibited at least 10-fold greater cytotoxic potency compared with uncomplexed cisplatin, reflecting an enhancement in intracellular accumulation and DNA platination. Mechanistic investigations showed that SQ-CDDP NP stimulated ROS production, expression of heavy metal-inducible and stress-inducible genes, stress kinase cascades, and apoptosis. In Apc<sup>Min/+</sup> mice, a model of intestinal tumorigenesis, oral administration of SQ-CDDP NP curtailed spontaneous tumor formation and azoxymethane-induced colon carcinogenesis with no apparent evidence of tissue toxicity. Our results offer preclinical validation of a nanocarrier formulation that can safely improve chemotherapeutic efficacy, address risks of drug resistance, and improve patient compliance by enabling oral administration. <i>Cancer Res; 77(11); 2964-75. ©2017 AACR</i>.
Recent Patents on Novel MCH1 Receptor Antagonists as Potential Anti-Obesity Drugs (2014)

Today, the 'obesity pandemic' is one of the biggest health issues around the world. Melanin-concentrating hormone (MCH), a hypothalamic neuropeptide, is one of the most potent, central stimulators of feeding and it also attenuates energy expenditure. Inhibitions of the MCH receptor, the melanin-concentrating hormone receptor-1 (MCHR1), has attracted considerable attention as a potential anti-obesity drug, during the last decade. Now, there are a large number of MCHR1 antagonists, pharmacological tools and clinical drug candidates that can provide clues to develop new structures with high potency and good pharmacokinetic profile. The function of MCHR1 in energy homeostasis, obesity, metabolic syndrome, mood disorders and inflammatory bowel disease is discussed. Relevant clinical trials and patent background information of the MCHR1 antagonists over the last 4 years are also reviewed.
Constitutional Interpretation: History and the High Court: A Bibliographical Survey (1982)

In this article the author analyses the peculiar method of constitutional interpretation adopted by the High Court of Australia. He compares this method to that used by the Supreme Court of America, and he also examines the particular views of the individual members of the High Court as it altered over the years. In particular the author questions the reluctance of the Court to refer to the Convention Debates and other historical material as tools in the interpretation of the Constitution. The article also provides, through its examination of both primary and secondary material, an extremely useful bibliography with which to approach the interpretation of the Constitution.
Efficacy and safety of nintedanib in patients with idiopathic pulmonary fibrosis (IPF) beyond week 52: Data from the Phase II TOMORROW trial (2016)

Background: Period 1 of the TOMORROW trial was a phase II, randomised, placebo-controlled trial of four doses of nintedanib (50 mg qd, 50 mg bid, 100 mg bid, 150 mg bid) in patients with IPF over 52 weeks. After completing period 1, patients had the option to continue treatment in a further blinded treatment phase (period 2).
in H.264/AVC interlaced coding (2007)

We propose a reference picture selection scheme in H.264/AVC interlaced coding. Only two reference fields for one B-field are adaptively selected depending on the scene characteristics. The proposed method provides 10% coding efficiency gain over non-adaptive selection methods with the same number of reference pictures.
Pulse-Echo Ultrasound Imaging Using an AlN Piezoelectric Micromachined Ultrasonic Transducer Array With Transmit Beam-Forming (2015)

This work demonstrates short-range and high-resolution ultrasonic imaging using 8 MHz aluminum nitride (AlN) piezoelectric micromachined ultrasonic transducer (PMUT) arrays, which are compatible with complementary metal-oxide semiconductor circuitry and wafer-level mass manufacture. Because AlN has a low dielectric constant, the PMUTs have low capacitance and a custom 1.8 V interface application-specified integrated circuit with on-chip charge-pump (1.8 to 32 V) is capable of providing sufficient output current to drive the PMUT array. Transmit beam-forming is used to produce a 90 μm focused acoustic beam-width. A pressure map measured with a needle hydrophone agrees with finite element method-simulations. Finally, 1-D and 2-D pulse-echo imaging was conducted using metal targets.
Is There “One” DLPFC in Cognitive Action Control? Evidence for Heterogeneity From Co-Activation-Based Parcellation (2012)

The dorsolateral prefrontal cortex (DLPFC) has consistently been implicated in cognitive control of motor behavior. There is, however, considerable variability in the exact location and extension of these activations across functional magnetic resonance imaging (fMRI) experiments. This poses the question of whether this variability reflects sampling error and spatial uncertainty in fMRI experiments or structural and functional heterogeneity of this region. This study shows that the right DLPFC as observed in 4 different experiments tapping executive action control may be subdivided into 2 distinct subregions-an anterior-ventral and a posterior-dorsal one -based on their whole-brain co-activation patterns across neuroimaging studies. Investigation of task-dependent and task-independent connectivity revealed both clusters to be involved in distinct neural networks. The posterior subregion showed increased connectivity with bilateral intraparietal sulci, whereas the anterior subregion showed increased connectivity with the anterior cingulate cortex. Functional characterization with quantitative forward and reverse inferences revealed the anterior network to be more strongly associated with attention and action inhibition processes, whereas the posterior network was more strongly related to action execution and working memory. The present data provide evidence that cognitive action control in the right DLPFC may rely on differentiable neural networks and cognitive functions.
Epidemiology of Peptic Ulcer Disease: Endoscopic Results of the Systematic Investigation of Gastrointestinal Disease in China (2010)

The prevalence of endoscopically confirmed PUD in this Shanghai population (17.2%) is substantially higher than in Western populations (4.1%). The majority of individuals with PUD were asymptomatic.
Scanning a Photonic Crystal Slab Nanocavity by Condensation of Xenon for Cavity QED Experiments (2005)

Condensing xenon gas onto a quantum dot photonic crystal slab nanocavity at 10-25K produces a shift of the nanocavity mode wavelength b; much as 5nm. Strong coupling anticrossing curves were obtained using this technique.
Joint Galois‐ and Linear Complex‐Field ST Codes (2006)

This chapter contains sections titled: GF-LCF ST Codes GF-LCF Layered ST Codes GF-LCF Coded Mimo OFDM Closing Comments
Image Analysis of Bone Tissue Remodelling Around Implants (2007)

Most of the state of the art image analysis programs available on the market have several things in common and irrespective of program, quite a lot of time is needed before results can be obtained. ...
Nonlinear noise waveform estimation for arbitrary signal based on Nyquist nonlinear model (2014)

The intra-channel nonlinear noise waveform of arbitrary signal is estimated by proposed Nyquist nonlinear model. The model can reach accuracies more than 95% and is applicable for various scenarios including NRZ/Nyquist formats and transmitter side dispersion pre-compensation.
Effects of Sublattice Symmetry and Frustration on Ionic Transport in Garnet Solid Electrolytes (2016)

We use rigorous group-theoretic techniques and molecular dynamics to investigate the connection between structural symmetry and ionic conductivity in the garnet family of solid Li-ion electrolytes. We identify new ordered phases and order-disorder phase transitions that are relevant for conductivity optimization. Ionic transport in this materials family is controlled by the frustration of the Li sublattice caused by incommensurability with the host structure at noninteger Li concentrations, while ordered phases explain regions of sharply lower conductivity. Disorder is therefore predicted to be optimal for ionic transport in this and other conductor families with strong Li interaction.
Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates (2023)

Following IVT administration, ANX007 distributes to sites within the retina that are relevant to neurodegenerative ophthalmic disease with clear evidence of C1q target engagement. Based on its mechanism of action inhibiting C1q and its downstream activity, ANX007 is predicted to mitigate tissue damage driven by classical complement activation in the retina. These data support further clinical evaluation of ANX007.
Simulation and Coordinated Control of Radiant and Convective Cooling Systems with Ventilation for Multi-Zone Buildings (2020)

The variety of ventilation requirements, thermal comfort specifications, and lower cooling loads for highperformance buildings can motivate the use of multiple HVAC systems whose dynamic interactions can strongly affect performance. We develop a Modelica energy model of a multi-zone residential building, based on an prototype EnergyPlus model distributed by the U.S. DOE, to quantify these interactions and design new controls to improve comfort. Fully dynamic radiant, convective, and ventilation subsystems are all integrated into a heterogeneous cooling system that has better performance than is achievable by a smaller collection of systems.
Prostein expression is highly restricted to normal and malignant prostate tissues (2004)

Prostein is exquisitely specific for prostate tissues, indicating a potential clinical utility of 10E3-G4-D3 as a diagnostic biomarker, and support the use of prostein as a novel target for development of prostein-specific antibody and T-cell based therapeutic strategies for prostate cancer.
CMUT as a chemical sensor for DMMP detection (2008)

We present an 18-MHz capacitive micromachined ultrasonic transducer (CMUT), used as a chemical sensor for detection of a common simulant for chemical weapons, dimethyl methylphosphonate (DMMP), in air. CMUTs are attractive for chemical sensor applications because of their unprecedented mass sensitivity per membrane area, low motional impedance, and high quality factor compared to other flexural-mode resonators. The device is composed of 1000 individual cells operating in parallel, which provides a robust operation with low false alarm rate and low motional impedance comparable to that of Quartz crystal resonators. We designed a CMUT-based oscillator with a phase noise of −84.8 dBc/Hz and −136.6 dBc/Hz at offset frequencies of 1 kHz and 1 MHz, respectively. The oscillator exhibits an Allan deviation of 0.6 Hz with a one-sigma error of 0.037 Hz, which translates to a theoretical limit of mass detection of 16.2 ag. The 18-MHz CMUT is functionalized with a 50-nm thick polymer layer, polyisobutylene (PIB). The described CMUT sensor demonstrates a volume sensitivity of 37.38 ppb/Hz to DMMP.
Point of View (2004)

From the Department of Orthopedic Surgery, University of California–San Francisco, San Francisco, CA. The manuscript submitted does not contain information about medical device(s)/drug(s). No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. Address correspondence to Sigurd Berven, MD, Department of Orthopedic Surgery, University of California–San Francisco, 500 Parnassus Avenue, MU320W, San Francisco, CA 94143; E-mail: [email protected]
(mitbearbeitet von Fritz Stöcker). Synthese paramagnetischer Zinnheterocyclen (1970)

Abstract 2‐Amino‐4.6‐di‐tert.‐butyl‐phenoxyl ( 1 ) reagiert mit Arylzinnhalogeniden unter Bildung 8‐gliedriger paramagnetischer Heterocyclen ( 3–7 ). Der Reaktionsweg und die Eigenschaften, insbesondere die Sn‐Hyperfeinstruktur der stabilen Radikale, werden untersucht.
Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates (2018)

In the 2014⁻2016 West Africa Ebola Virus (EBOV) outbreak, there was a significant concern raised about the potential for secondary bacterial infection originating from the gastrointestinal tract, which led to the empiric treatment of many patients with antibiotics. This retrospective pathology case series summarizes the gastrointestinal pathology observed in control animals in the rhesus EBOV-Kikwit intramuscular 1000 plaque forming unit infection model. All 31 Non-human primates (NHPs) exhibited lymphoid depletion of gut-associated lymphoid tissue (GALT) but the severity and the specific location of the depletion varied. Mesenteric lymphoid depletion and necrosis were present in 87% (27/31) of NHPs. There was mucosal barrier disruption of the intestinal tract with mucosal necrosis and/or ulceration most notably in the duodenum (16%), cecum (16%), and colon (29%). In the intestinal tract, hemorrhage was noted most frequently in the duodenum (52%) and colon (45%). There were focal areas of bacterial submucosal invasion in the gastrointestinal (GI) tract in 9/31 (29%) of NHPs. Only 2/31 (6%) had evidence of pancreatic necrosis. One NHP (3%) experienced jejunal intussusception which may have been directly related to EBOV. Immunofluorescence assays demonstrated EBOV antigen in CD68+ macrophage/monocytes and endothelial cells in areas of GI vascular injury or necrosis.
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis (2020)

The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a critical threat to human health, and alternative treatment strategies are urgently required. We investigated the ability of the hydroxyquinoline analog ionophore PBT2 to restore antibiotic sensitivity in polymyxin-resistant, ESBL-producing, carbapenem-resistant Gram-negative human pathogens. PBT2 resensitized <i>Klebsiella pneumoniae</i>, <i>Escherichia coli</i>, <i>Acinetobacter baumannii</i>, and <i>Pseudomonas aeruginosa</i> to last-resort polymyxin class antibiotics, including the less toxic next-generation polymyxin derivative FADDI-287, in vitro. We were unable to select for mutants resistant to PBT2 + FADDI-287 in polymyxin-resistant <i>E. coli</i> containing a plasmid-borne <i>mcr-1</i> gene or <i>K. pneumoniae</i> carrying a chromosomal <i>mgrB</i> mutation. Using a highly invasive <i>K. pneumoniae</i> strain engineered for polymyxin resistance through <i>mgrB</i> mutation, we successfully demonstrated the efficacy of PBT2 + polymyxin (colistin or FADDI-287) for the treatment of Gram-negative sepsis in immunocompetent mice. In comparison to polymyxin alone, the combination of PBT2 + polymyxin improved survival and reduced bacterial dissemination to the lungs and spleen of infected mice. These data present a treatment modality to break antibiotic resistance in high-priority polymyxin-resistant Gram-negative pathogens.
Synthesis, Photophysical Properties, and Nanocrystal Formation of a New Class of Tetra‐N‐Substituted Perylenes (2003)

Tetra(carboxamido)perylen-Farbstoffe können nach einer allgemeinen Methode synthetisiert werden. In DMSO bildet Derivat A nanokristalline Aggregate, deren photophysikalische Eigenschaften sich signifikant von denen des Monomers unterscheiden (siehe Bild). Die Struktur der Aggregate wurde rasterkraftmikroskopisch untersucht.
Prolactin Responses to Thyrotropin-Releasing Hormone in Protein-Calorie Malnutrition (1975)

Basal plasma prolactin (hPRL) concentration is low, but the response to thyrotropin-releasing hormone (TRH) is within the normal range, in children with protein-carlorie malnutrition (PCM) before treatment. Treatment results in increased basal hPRL concentration and an increased response to TRH. The above findings contrast with normal or high basal TSH and the normal or exaggerated response to TRH provocation in untreated PCM. The reason for this divergence is obscure.
Near-field scattering of longitudinal fields (2003)

Longitudinal fields created in strongly focused laser beams are investigated by near-field optical microscopy. Sharp metallic and dielectric tips are raster scanned through the focus of these modes. It is found that regardless of the tip material, the signal scattered by the tip is a measure for the strength of the local longitudinal field. A surprising contrast reversal is observed between the images obtained with a metallic tip and the images obtained with a dielectric tip. The contrast reversal originates from a non-negligible tip–sample interaction.
Guiding the Exploration of Scatter Plot Data Using Motif-Based Interest Measures (2015)

Finding interesting patterns in large scatter plot spaces is a challenging problem and becomes even more difficult with increasing number of dimensions. Previous approaches for exploring large scatter plot spaces like e.g., the well-known Scagnostics approach, mainly focus on ranking scatter plots based on their global properties. However, often local patterns contribute significantly to the interestingness of a scatter plot. We are proposing a novel approach for the automatic determination of interesting views in scatter plot spaces based on analysis of local scatter plot segments. Specifically, we automatically classify similar local scatter plot segments, which we call scatter plot motifs. Inspired by the well-known tf-idf approach from information retrieval, we compute local and global quality measures based on certain frequency properties of the local motifs. We show how we can use these to filter, rank and compare scatter plots and their incorporated motifs. We demonstrate the usefulness of our approach with synthetic and real-world data sets and showcase our corresponding data exploration tool that visualizes the distribution of local scatter plot motifs in relation to a large overall scatter plot space.