gebhart/patrepeval huggingface dataset:
CFD-based dielectric design of high voltage circuit breakers using air, CO<inf>2</inf>, N<inf>2</inf> and SF<inf>6</inf> (2014)

By virtue of its excellent thermodynamic, dielectric and transport properties, SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> is widely used in the electrical industry, especially in the high voltage circuit breaker technology. However due to its high global warming potential other gases such as Air, CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> are considered in some cases also mixed with SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> .
Supplementary Table 3 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway (2023)

Supplementary Table 3 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway
Adaptive And Repetitive Digital Control Algorithms for Noncircular Machining (1988)

This paper presents experimental results of digital tracking control algorithms applied to a hydraulic linear actuating system for tool positioning in noncircular machining. Noncircular machining is accomplished by controlling the tool position in the direction normal to the surface of the rotating workpiece. Implementation of two robust tracking controllers is presented: one is the adaptive zero phase error tracking controller for tracking arbitrary shaped desired signals, and the other is the digital repetitive controller for tracking periodic desired signals.
Performance limits in fading MIMO channels (2003)

The multiple-input multiple-output (MIMO) channel is typically modeled as a randomly varying fading channel. Therefore the channel capacity is also a random variable and can vary from zero to infinity in a Rayleigh channel. Given this random nature of the channel capacity when the transmitter does not have channel knowledge, any signaling rate it chooses to use may not be supported by the channel with a finite probability, leading to a transmission error even when ideal channel coding for that chosen rate is employed. Therefore, in the absence of channel knowledge, the packet (or block) error rate (PER) is equal to the outage of capacity for the specified signaling rate. We study the fundamental limits on packet error rate versus signaling rate versus average SNR and the performance tradeoffs therein. We then examine such tradeoffs for several specific space-time coding schemes have. been. proposed that maximize either rate or diversity. These coding schemes modify the achievable capacity of the channel and therefore also the corresponding performance tradeoffs.
Behavioural characterization of four endemic Stachys taxa (2010)

We performed a basic behavioral characterization of methanol extracts of four Balkan endemic Stachys taxa: S. anisochila (SA), S. beckeana (SB), S. plumosa (SP) and S. alpina subsp. dinarica (SAD). The behavioral activity of extracts dosed intraperitoneally in the range 100-400 mg/kg was examined in adult male Wistar rats, in the elevated plus maze, spontaneous locomotor activity, and grip strength tests, mainly predictive of anxiolytic, sedative and myorelaxant actions, respectively. All investigated Stachys extracts lacked anxiolytic or myorelaxant activities, while SB at 400 mg/kg exerted an anxiogenic-like effect. The study with the selective antagonist beta-CCt showed that the sedative effect of SAD was only partially mediated by GABAA receptors containing the alpha1-subunit. While discernible, the behavioral effects of SA and SP were not distinct. In all extracts, chlorogenic acid and verbascoside were identified. In SA, SB, and SAD the flavonoid fraction was constituted of isoscutellarein and hypolaetine glycosides, while in SP chrysoeriol and apigenin glycosides were present. The results reveal the psychotropic potential of four endemic Stachys taxa, of which SAD appeared most promising as a natural sedative.
ChemInform Abstract: Cobalt‐Catalyzed Hydro‐Sulfenylation of Michael Acceptors. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pregnancy following robot-assisted laparoscopic partial cystectomy and gonadotropin-releasing hormone agonist treatment within three months in an infertile woman with bladder endometriosis (2018)

Robot-assisted complete resection of deep-infiltrating endometriosis and bladder repair immediately followed by GnRHa therapy and medical assistance improves reproductive outcomes efficiently in women with endometriosis-associated infertility.
Development of on board, highly flexible, Galileo signal generator ASIC (2007)

Alcatel Alenia Space is deeply involved in the Galileo program at many stages. In particular, Alcatel Alenia Space has successfully designed and delivered the very first navigation signal generator, based on a 0.35mum Atmel ASIC technology, which has been launched in the satellite demonstrator GIOVE-A in December 2005. The Galileo project is now in a second phase including the development of four of the thirty satellites of the final constellation. The new navigation signal generator requires both high performance and high flexibility (various waveforms to cope with the different Galileo services: open, commercial, governmental ...) for a very long life time system. Besides, the challenge is increased due to the specific space constraints such as mass, volume and power consumption. These requirements will be achieved through the implementation of a 3 million gates ASIC in a 0.18mum European Radiation Tolerant Atmel technology. This paper will, after a brief description of Galileo system, present the constraints of space environment and technologies challenges. It will then present the ASIC and the development flow of this project, emphasizing the up to date tools that have been used (architectural synthesis, physical synthesis). A conclusion will then be drawn on the requirements on technology and tools for space domain
On the Cost of Secure Association of Information Centric Things (2016)

Information Centric Networking (ICN) paradigms nicely fit the world of wireless sensors, whose devices have tight constraints. In this poster, we compare two alternative designs for secure association of new IoT devices in existing ICN deployments, which are based on asymmetric and symmetric cryptography respectively. While the security properties of both approaches are equivalent, an interesting trade-off arises between properties of the protocol vs properties of its implementation in current IoT boards. Indeed, while the asymmetric-keys based approach incurs a lower traffic overhead (of about 30%), we find that its implementation is significantly more energy- and time-consuming due to the cost of cryptographic operations (it requires up to 41x more energy and 8x more time).
Supplemental Figures 1 - 8 from Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells (2023)

&lt;p&gt;Supplemental Fig. 1: Characteristics of T cell activation and killing induced by HER2-TDB. Supplemental Fig 2: Activation of T cells by HER2-TDB induces T cell proliferation. Supplemental Figure 3. Activity of HER2-TDB in NOD-SCID mice is dependent on human PBMCs. Supplemental Figure 4. TDB mediated killing by CD3-TG splenic T cells. Supplemental Figure 5. Effect of 4D5 on established mammary tumors in MMTV-huHER2 transgenic mice. CD3-TG T cells express both mouse and human CD3 on approximately 50% level of respective Balb/c mouse or human T cells. Supplemental Figure 6. Anti-tumor activity of HER2-TDB is T cell dependent. Supplemental Figure 7. T cells in CT26-HER2 tumors display CD69 activation marker. Supplemental Figure 8. CT-26-HER2 tumor infiltrating T cells express PD-1. CT-26-HER2 tumor cells express PD-L1.&lt;/p&gt;
Time series prediction via two-step clustering (2015)

Linear and nonlinear models for time series analysis and prediction are well-established. Clustering methods have also been applied to this area. This paper explores a framework that can be used to cluster time series data. The range of values of a time series is clustered. Then the time series is clustered by data windows that flow into the initial set of value clusters. This allows predictive temporal patterns to be discovered across the whole range of values.
ChemInform Abstract: Chelation‐Directed Asymmetric Lithiation and C‐Substitution of 1,2,4‐ Butanetriol Acetonide. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene‐hopene cyclases (2001)

Various vinyl sulfide and ketene dithioacetal derivatives of truncated 2,3-oxidosqualene were developed. These compounds, having the reactive functions at positions C-2, C-15 and C-19 of the squalene skeleton, were studied as inhibitors of pig liver and Saccharomyces cerevisiae oxidosqualene cyclases (OSC) (EC 5.4.99.7) and of Alicyclobacillus acidocaldarius squalene hopene cyclase (SHC) (EC 5.4.99.-). They contain one or two sulfur atoms in alpha-skeletal position to carbons considered to be cationic during enzymatic cyclization of the substrate and should strongly interact with enzyme nucleophiles of the active site. Most of the new compounds are inhibitors of the OSC and of SHC, with various degrees of selectivity. The methylthiovinyl derivative, having the reactive group at position 19, was the most potent and selective inhibitor of the series toward S. cerevisiae OSC, with a concentration inhibiting 500% of the activity of 50 nM, while toward the animal enzyme it was 20 times less potent. These results could offer new insight for the design of antifungal drugs.
Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer (2017)

Diversity in colorectal cancer biology is associated with variable responses to standard chemotherapy. We aimed to identify and validate DNA hypermethylated genes as predictive biomarkers for irinotecan treatment of metastatic CRC patients. Candidate genes were selected from 389 genes involved in DNA Damage Repair by correlation analyses between gene methylation status and drug response in 32 cell lines. A large series of samples (n=818) from two phase III clinical trials was used to evaluate these candidate genes by correlating methylation status to progression-free survival after treatment with first-line single-agent fluorouracil (Capecitabine or 5-fluorouracil) or combination chemotherapy (Capecitabine or 5-fluorouracil plus irinotecan (CAPIRI/FOLFIRI)). In the discovery (n=185) and initial validation set (n=166), patients with methylated <i>Decoy Receptor 1</i> (<i>DCR1)</i> did not benefit from CAPIRI over Capecitabine treatment (discovery set: HR=1.2 (95%CI 0.7-1.9, <i>p</i>=0.6), validation set: HR=0.9 (95%CI 0.6-1.4, <i>p</i>=0.5)), whereas patients with unmethylated <i>DCR1</i> did (discovery set: HR=0.4 (95%CI 0.3-0.6, <i>p</i>=0.00001), validation set: HR=0.5 (95%CI 0.3-0.7, <i>p</i>=0.0008)). These results could not be replicated in the external data set (n=467), where a similar effect size was found in patients with methylated and unmethylated <i>DCR1</i> for FOLFIRI over 5FU treatment (methylated <i>DCR1</i>: HR=0.7 (95%CI 0.5-0.9, <i>p</i>=0.01), unmethylated <i>DCR1</i>: HR=0.8 (95%CI 0.6-1.2, <i>p</i>=0.4)). In conclusion, <i>DCR1</i> promoter hypermethylation status is a potential predictive biomarker for response to treatment with irinotecan, when combined with capecitabine. This finding could not be replicated in an external validation set, in which irinotecan was combined with 5FU. These results underline the challenge and importance of extensive clinical evaluation of candidate biomarkers in multiple trials.
An electrically tunable depth-of-field endoscope using a liquid crystal lens as an active focusing element (2013)

An electrically tunable depth-of-field (DOF) endoscope using a liquid crystal lens (LC lens) as an active focusing element is demonstrated. The optical mechanism of the electrically-tunable DOF endoscope adopting a two-mode switching LC lens is introduced. The two-mode switching LC lens provides not only a positive lens power but also a negative lens power. Therefore, we could extend the range of DOF originally from 27 mm ~ 55 mm to 12.4 mm ~ 76.4 mm by using the two-mode switching LC lens as an active focusing element. The detail derivations of the optical mechanism of the endoscopic system adopting a LC lens are invistgated. The more detail experimental results are demonstrated. We believe this study can provide a more detail understanding of an endoscopic system adopting a tunable focusing lens.
Non-additive genome-wide association scan reveals a new gene associated with habitual coffee consumption (2016)

Coffee is one of the most consumed beverages world-wide and one of the primary sources of caffeine intake. Given its important health and economic impact, the underlying genetics of its consumption has been widely studied. Despite these efforts, much has still to be uncovered. In particular, the use of non-additive genetic models may uncover new information about the genetic variants driving coffee consumption. We have conducted a genome-wide association study in two Italian populations using additive, recessive and dominant models for analysis. This has uncovered a significant association in the PDSS2 gene under the recessive model that has been replicated in an independent cohort from the Netherlands (ERF). The identified gene has been shown to negatively regulate the expression of the caffeine metabolism genes and can thus be linked to coffee consumption. Further bioinformatics analysis of eQTL and histone marks from Roadmap data has evidenced a possible role of the identified SNPs in regulating PDSS2 gene expression through enhancers present in its intron. Our results highlight a novel gene which regulates coffee consumption by regulating the expression of the genes linked to caffeine metabolism. Further studies will be needed to clarify the biological mechanism which links PDSS2 and coffee consumption.
Non-invasive Authentication of Mail Packages using Nuclear Quadrupole Resonance Spectroscopy (2022)

Abstract The international postal network is one of the most widely used methods for correspondence throughout the world. Most postal traffic across the globe consists of legitimate interpersonal, business-consumer, and business-business communications. However, the global postal system is also utilized for criminal activity. In particular, it is often utilized to ship and distribute contraband, including illegal psychoactive drugs such as fentanyl and heroin, to consumers. Existing technological solutions are capable of identifying synthetic opioids and other illegal drugs within packages, but are accompanied by several disadvantages that make them unsuitable for large-scale authentication of international mail traffic. This paper presents a novel method for non-invasive authentication of mail packages that overcomes these challenges. The approach uses nuclear quadrupole resonance (NQR) spectroscopy to detect and quantify the presence of known active pharmaceutical ingredients (APIs) within the package. It has been experimentally demonstrated using a benchtop prototype. Test results from a variety of package types demonstrate the effectiveness of the proposed authentication approach.
Multi-Sensor Receiver Deghosting Using Data Domain Sparseness Weights (2018)

Summary While the benefits of vertical particle velocity measurements are well known for towed streamer receiver deghosting, in many cases high noise levels can cause practical issues. We describe an inversion-driven receiver deghosting approach which is jointly constrained by hydrophone data and prior wavefield separated data. Prior wavefield separated data can relate to an up-going or down-going wavefield, obtained by combining hydrophone and particle velocity data. Use of prior wavefield separation data provides the joint inversion with signal at hydrophone notch frequencies, as well as making it less sensitive to variations in the free surface datum than hydrophone-only inversion methods. The use of data domain sparseness constraints makes the approach practical as it may be applied to data without explicit prior denoise. The proposed method is validated on synthetic and real data examples.
Low dose SIMOX and impact of ITOX process on quality of SOI film (2002)

Summary form only given. Internal thermal oxidation (ITOX) has been shown to improve the quality of buried oxide (BOX) in low dose (4E17 cm/sup -2/) SOI SIMOX material. SOI film quality of ITOX SIMOX was determined to be as good as bulk in terms of the integrity of gate oxide grown on it. We have investigated low dose SIMOX material and the impact of its high temperature annealing as well as the subsequent ITOX process on structure and electrical properties of its SOI film. Several new findings about the SOI film quality and its relationship to process parameters are reported.
MQJoin (2016)

Database architectures typically process queries one-at-a-time, executing concurrent queries in independent execution contexts. Often, such a design leads to unpredictable performance and poor scalability. One approach to circumvent the problem is to take advantage of sharing opportunities across concurrently running queries. In this paper we propose Many-Query Join (MQJoin), a novel method for sharing the execution of a join that can efficiently deal with hundreds of concurrent queries. This is achieved by minimizing redundant work and making efficient use of main-memory bandwidth and multi-core architectures. Compared to existing proposals, MQJoin is able to efficiently handle larger workloads regardless of the schema by exploiting more sharing opportunities. We also compared MQJoin to two commercial main-memory column-store databases. For a TPC-H based workload, we show that MQJoin provides 2--5x higher throughput with significantly more stable response times.
Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo (2020)

Regenerative tissue-engineered matrix-based heart valves (TEM-based TEHVs) may become an alternative to currently-used bioprostheses for transcatheter valve replacement. We recently identified TEM-based TEHVs-geometry as one key-factor guiding their remodeling towards successful long-term performance or failure. While our first-generation TEHVs, with a simple, non-physiological valve-geometry, failed over time due to leaflet-wall fusion phenomena, our second-generation TEHVs, with a computational modeling-inspired design, showed native-like remodeling resulting in long-term performance. However, a thorough understanding on how TEHV-geometry impacts the underlying host cell response, which in return determines tissue remodeling, is not yet fully understood. To assess that, we here present a comparative samples evaluation derived from our first- and second-generation TEHVs. We performed an in-depth qualitative and quantitative (immuno-)histological analysis focusing on key-players of the inflammatory and remodeling cascades (M1/M2 macrophages, α-SMA<sup>+</sup>- and endothelial cells). First-generation TEHVs were prone to chronic inflammation, showing a high presence of macrophages and α-SMA<sup>+</sup>-cells, hinge-area thickening, and delayed endothelialization. Second-generation TEHVs presented with negligible amounts of macrophages and α-SMA<sup>+</sup>-cells, absence of hinge-area thickening, and early endothelialization. Our results suggest that TEHV-geometry can significantly influence the host cell response by determining the infiltration and presence of macrophages and α-SMA<sup>+</sup>-cells, which play a crucial role in orchestrating TEHV remodeling.
Interdomain flip-flop motion visualized in flavocytochrome cellobiose dehydrogenase using high-speed atomic force microscopy during catalysis (2017)

Cellobiose dehydrogenase (CDH) is a dual domain flavocytochrome, which consists of a dehydrogenase (DH) domain containing a flavin adenine dinucleotide and a cytochrome (CYT) domain containing <i>b</i>-type heme. To directly visualize the dynamic domain motion of class-I CDH from <i>Phanerochaete chrysosporium</i> (<i>Pc</i>CDH) during catalysis using high-speed atomic force microscopy, the apo-form of <i>Pc</i>CDH was anchored to a heme-immobilized flat gold surface that can specifically fix the orientation of the CYT domain. The two domains of CDH are found to be immobile in the absence of cellobiose, whereas the addition of cellobiose triggers an interdomain flip-flop motion involving domain-domain association and dissociation. Our results indicate that dynamic motion of a dual domain enzyme during catalysis induces efficient electron transfer to an external electron acceptor.
Interfacial surface charge and the selectivity of cation transport through a liquid membrane by a lipophilic crown ether carboxylic acid (1986)

A kinetic model has been developed to describe the transport selectivities exhibited by a liquid membrane system incorporating a lipophilic crown ether carboxylic acid carrier. Under conditions of rate-limiting cation/carrier complex desorption from the interface, the rate an ion is extracted is related to the fraction of interfacial sites occupied by the carrier complex of that ion. The fractional site coverage is related to bulk aqueous concentrations and the surface charge by a modified Stern adsorption isotherm. Experimental values of constants of complexation and acidity at the interface were determined from single-ion transport studies and were utilized to correlate transport selectivities for binary K+/Na+ and Sr2+/K+ mixtures. The overall transport selectivity is shown to be a composite of both thermodynamic and kinetic factors. The relevance of the model to extraction and transport in related systems is discussed.
Comments and Corrections to “A New Paradigm for Spectrum Sharing Between Cellular Wireless Communications and Radio Astronomy Systems” [Sep 17 3985-3999] (2018)

In <xref ref-type="bibr" rid="ref1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[1]</xref> , <xref ref-type="fig" rid="fig10" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Fig. 10</xref> should appear as:
Service America!: Doing Business in the New Economy (1985)

This classic service primer shows how to make service quality an imperative in the organization and increase profits with customer loyalty.
Neutrophil Gelatinase Associated Lipocalin in Acute Kidney Injury (2013)

Based on the evidence reviewed, it is clear that patient NGAL level is an appropriate, sensitive, and specific early biomarker of AKI caused by a variety of different etiologies. It is advised that a multidisciplinary group of experts come together to make recommendations and propose a consensus of clinical procedures to advance the most efficacious NGAL monitoring protocol for early detection and treatment of patients with AKI.