gebhart/patrepeval huggingface dataset:
Ab initio IGLO study of the .phi.- and .chi.-angle dependence of the carbon-13 chemical shifts in the model peptide N-acetyl-N'-methylglycinamide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb initio IGLO study of the .phi.- and .chi.-angle dependence of the carbon-13 chemical shifts in the model peptide N-acetyl-N'-methylglycinamideDing Jiao, Michael Barfield, and Victor J. HrubyCite this: J. Am. Chem. Soc. 1993, 115, 23, 10883–10887Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00076a052https://doi.org/10.1021/ja00076a052research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Sib‐pair collection strategies for complex diseases (1998)

When planning an affected sib pair collection for use in a genomewide search for complex trait loci, researchers must ask: (a) Which family structures will yield the most informative pairs? and (b) Should recruitment extend beyond the index sib pair? The optimal collection strategy will depend on the trait's genetic architecture, but this is rarely known for non-Mendelian diseases. In the present report, we study the consequences of collecting only those sib pairs arising from pedigrees with a precisely specified structure as opposed to a strategy that collects all affected sib pairs at random (i.e., blind to the affection status of first-degree relatives). The former approach turns out to be risky because the power of specific pedigree structures can vary dramatically even among models producing identical observable parameters (such as population prevalence and sibling recurrence rate). In contrast, the latter approach typically involves only a modest loss of power as compared with the optimal (but unknowable) design. Further, we compare the strategy of collecting all affected sib pairs at random with the alternative of imposing some modest limitations on family structure (e.g., presence of at least one unaffected sib or parent). The latter approach generally provides some increase in power but entails additional effort to contact and phenotype relatives: the overall merit of imposing such requirements needs to be evaluated in the context of the specific disease to be studied and of the clinical and analytical resources available. In addition, these findings suggest that a further explanation for failure to replicate positive complex trait linkages lies in differences in ascertainment strategy between data sets.
Modification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagen (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagenYuichi Hashimoto, Koichi Shudo, and Toshihiko OkamotoCite this: J. Am. Chem. Soc. 1982, 104, 26, 7636–7640Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00390a040https://doi.org/10.1021/ja00390a040research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma (2017)

Transplantation of iPSC-TM can restore IOP and outflow facility in aged Tg-MYOCY437H mice. This type of stem cell-based therapy is a promising possibility for restoration of IOP control in some glaucoma patients.
<title>Electroabsorption modulator packaging for greater than 20-GHz link applications</title> (1999)

Efficient, linear, broadband optical modulators are an essential component in wide bandwidth optical links for high fidelity distribution and processing of wideband signals. We discuss the packaging issues and remedies for the packaging of electroabsorption modulators for greater than 20 GHz link applications. The EAM is a waveguide semiconductor quantum well device which we have demonstrated to have a excellent linearity and electrical to optical conversion efficiency. Several important issues require resolution in order to produce a high bandwidth, packaged product. These include temperature control, EAM back-side metallization, attachment of EAM to submount, Product hermeticity, alignment and attachment of input and output fibers to the device at sub- micron tolerances, retaining this alignment over operational temperatures and anticipated vibration environments, and elimination of outgassing materials that may serve as failure initiators to optical facets. This paper addresses these issues.
Blue photoluminescence from rapid thermally oxidized porous silicon following storage in ambient air (1995)

We have studied the temporal variation of the visible photoluminescence from rapid thermally oxidized porous silicon prepared from n+ substrates. In contrast to the red (slow band) emission, which is observable immediately after high-temperature oxidation, the blue (fast band) emission is shown to become prevalent only after samples are stored in ambient air. The intensity of the blue emission increases with progressive aging, the magnitude of the increase being dependent on the temperature at which the material is oxidized. Thermal treatment of aged rapid thermally oxidized material can reduce and even quench the blue photoluminescence. Quenching is reversible in that the photoluminescence re-appears after further aging at room temperature.
Improvement of performance of a tracking servo system for an optical disk drive (1999)

This paper describes a high speed and precise tracking servo system for an optical disk drive. For efficient production of television programs, an optical video disk recording system with high data transfer rate and large capacity is being developed. To realize a high data transfer rate, a high disk rotation speed is needed. Together with the utilization of short-wavelength lasers and an objective lens with a high numerical aperture, the track pitch on the disk must be reduced to enlarge the recording capacity.
ChemInform Abstract: CHEMISTRY VIA METAL ATOM COCONDENSATION: ISOMERIZATION AND COMPLEXATION REACTIONS OF ORGANOCYCLOPROPANES AND SPIROCYCLES (1980)

Abstract Cokondensationsreaktionen von Metallatomen mit Cyclopropan‐ und Spiroverbindungen unterschiedlicher Struktur werden untersucht.
2‐Diazoacetoacetic Acid, an Efficient and Convenient Reagent for the Synthesis of α‐Diazo‐β‐ketoesters. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor (2003)

Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1-8-5GalNAc) bound to H-2Kb, fully crossreactive with the nonglycosylated variant. Molecular modeling showed that the central P5-Thr-GalNAc residue points into the C pocket and forms van der Waals and hydrogen bond interactions with the MHC class I. As predicted, GalNAc, a modified peptide carrying an additional anchor in the central C anchor pocket, increased the affinity by approximately 100-fold compared with the native low-affinity peptide (MUC1-8). The findings demonstrate that glycopeptides associated with MHC class I molecules can use GalNAc to anchor the peptide in the groove and enable high-affinity binding.
08021 Summary – Numerical Validation in Current Hardware Architectures (2008)

Numerical validation in current hardware architectures - From embedded system to high-end computational grids Topics List of participants Schedule List of talks
50GHz Ge Waveguide Electro-Absorption Modulator Integrated in a 220nm SOI Photonics Platform (2015)

We report waveguide-integrated Ge electro-absorption modulators operating at 1615nm wavelength with 3dB bandwidth beyond 50GHz and a capacitance of 10fF.A 2V voltage swing enables 4.6dB DC extinction ratio for 4.1dB insertion loss.
The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy (2018)

Antileukemia immunity plays an important role in disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Thus, antigen-specific immunotherapy holds promise for strengthening immune control in CML but requires the identification of CML-associated targets. In this study, we used a mass spectrometry-based approach to identify naturally presented HLA class I- and class II-restricted peptides in primary CML samples. Comparative HLA ligandome profiling using a comprehensive dataset of different hematological benign specimens and samples from CML patients in deep molecular remission delineated a panel of novel frequently presented CML-exclusive peptides. These nonmutated target antigens are of particular relevance because our extensive data-mining approach suggests the absence of naturally presented BCR-ABL- and ABL-BCR-derived HLA-restricted peptides and the lack of frequent tumor-exclusive presentation of known cancer/testis and leukemia-associated antigens. Functional characterization revealed spontaneous T-cell responses against the newly identified CML-associated peptides in CML patient samples and their ability to induce multifunctional and cytotoxic antigen-specific T cells de novo in samples from healthy volunteers and CML patients. Thus, these antigens are prime candidates for T-cell-based immunotherapeutic approaches that may prolong TKI-free survival and even mediate cure of CML patients.
First and second-order PMD impact over 100Gbps polarization-multiplexed multi-band coherent OFDM system under realistic field conditions (2011)

International audience
Ammonium removal from wastewater via struvite pyrolysate recycling with Mg(OH)2 addition (2013)

Magnesium ammonium phosphate (MAP) pyrolysate recycling technology was investigated with Mg(OH)2-mediated pyrolysis. The results revealed that the removal ratio of ammonium was stable at about 75%, and could be increased to 79% after additional acidolysis. The phosphate concentration in the supernate was low at 2 mg/L. The optimum conditions for ammonia release were a 1:1 molar ratio of Mg(OH)2:NH4(+), a heating temperature of 110 °C and a heating time of 3 h. With continual additions of Mg(OH)2 to release ammonia, magnesium phosphate (Mg3(PO4)2) was suggested as a possible derivative. However, with Mg(OH)2-mediated pyrolysis, the growth and nucleation of MAP was inhibited during MAP pyrolysate recycling.
New platform for experimental education in electrical generation based on wind energy systems (2009)

In this paper, the development of a physical platform and the description of a specific methodology to be employed for experimental teaching in wind energy electrical generation in the `Electrical Generation with Renewable Energy Sources' course, within the Electrical Engineering educational program at the Universidad Politecnica de Madrid, is presented. The developed platform has a reduced-size wind turbine to which some different types of scaled-size electrical generation systems can be coupled. The instructors can easily configure the specific structure of this platform for each laboratory session. A regulated electric fan is employed to generate and control the speed of the wind that is incident on the wind rotor. Students can configure the session specifications and are able to control the execution of each experiment, as well as to analyze the results in a comfortable way using user-friendly interface software. This paper also describes, as a case study, the application of the proposed methodology in one of the laboratory sessions.
A 2.4-GHz Ternary Sequence Spread Spectrum OOK Transceiver for Reliable and Ultra-Low Power Sensor Network Applications (2017)

The ON/OFF keying (OOK) transmitter is re-investigated to utilize its structural simplicity and low power features for the reliable, ultra-low power sensor network applications. A novel architecture of 2.4-GHz ternary sequence spread spectrum (TSSS) OOK transceiver with spreading gain, spur suppression, and dual-mode detection techniques is presented. A random bi-phase operation of a power amplifier rejects the intrinsic spur of spread spectrum OOK transmitter by 22 dB. A proposed TSSS-OOK transmitter supports a variable spread spectrum, such as 1 b to 4 chips (1/4), 3/8, and 5/32 and a dual reception of the coherent as well as non-coherent mode, achieving 12-dB SNR gain. For the power optimized frequency synthesis, both a phase locked loop (PLL) and a frequency locked loop (FLL) are merged with a single voltage controlled oscillator as a dual-precision frequency synthesizer, where the high-precision PLL is activated for the coherent reception and the low power, moderate precision FLL is activated for the non-coherent reception. The single-chip transceiver in 90-nm CMOS occupies an active area of 2.4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and measures 1Mb/s, 22-dB spur-suppressed output spectrum, 5.5% EVM, and a sensitivity of -81 dBm at non-coherent mode and -93 dBm at coherent mode, dissipating 2.17 mW at TX and 0.614 mW at RX.
Data from An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Tissue factor (TF) is aberrantly expressed in solid cancers and is thought to contribute to disease progression through its procoagulant activity and its capacity to induce intracellular signaling in complex with factor VIIa (FVIIa). To explore the possibility of using tissue factor as a target for an antibody-drug conjugate (ADC), a panel of human tissue factor–specific antibodies (TF HuMab) was generated. Three tissue factor HuMab, that induced efficient inhibition of TF:FVIIa-dependent intracellular signaling, antibody-dependent cell-mediated cytotoxicity, and rapid target internalization, but had minimal impact on tissue factor procoagulant activity &lt;i&gt;in vitro&lt;/i&gt;, were conjugated with the cytotoxic agents monomethyl auristatin E (MMAE) or monomethyl auristatin F (MMAF). Tissue factor–specific ADCs showed potent cytotoxicity &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;, which was dependent on tissue factor expression. TF-011-MMAE (HuMax-TF-ADC) was the most potent ADC, and the dominant mechanism of action &lt;i&gt;in vivo&lt;/i&gt; was auristatin-mediated tumor cell killing. Importantly, TF-011-MMAE showed excellent antitumor activity in patient-derived xenograft (PDX) models with variable levels of tissue factor expression, derived from seven different solid cancers. Complete tumor regression was observed in all PDX models, including models that showed tissue factor expression in only 25% to 50% of the tumor cells. In conclusion, TF-011-MMAE is a promising novel antitumor agent with potent activity in xenograft models that represent the heterogeneity of human tumors, including heterogeneous target expression. &lt;i&gt;Cancer Res; 74(4); 1214–26. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Identification in the mouldHypocrea jecorinaof a gene encoding an NADP+: d-xylose dehydrogenase (2007)

A gene coding for an NADP(+)-dependent d-xylose dehydrogenase was identified in the mould Hypocrea jecorina (Trichoderma reesei). It was cloned from cDNA, the active enzyme was expressed in yeast and a histidine-tagged enzyme was purified and characterized. The enzyme had highest activity with d-xylose and significantly smaller activities with other aldose sugars. The enzyme is specific for NADP(+). The K(m) values for d-xylose and NADP(+) are 43 mM and 250 microM, respectively. The role of this enzyme in H. jecorina is unclear because in this organism d-xylose is predominantly catabolized through a path with xylitol and d-xylulose as intermediates and the mould is unable to grow on d-xylonic acid.
Lightweight biometric detection system for human classification using pyroelectric infrared detectors (2006)

We use pyroelectric detectors that are differential in nature to detect motion in humans by their heat emissions. Coded Fresnel lens arrays create boundaries that help to localize humans in space as well as to classify the nature of their motion. We design and implement a low-cost biometric tracking system by using off-the-shelf components. We demonstrate two classification methods by using data gathered from sensor clusters of dual-element pyroelectric detectors with coded Fresnel lens arrays. We propose two algorithms for person identification, a more generalized spectral clustering method and a more rigorous example that uses principal component regression to perform a blind classification.
Implementation of multi-point measurement techniques for PQ monitoring (2004)

The problem of locating the sources of the harmonic distortion in power networks is still a critical task. Several methods based on multi-point measurement techniques have been recently proposed in the literature for harmonic pollution monitoring. The main goal of this study is to compare the two most powerful tools designed for this purpose. In this paper the results of both computer simulations on an IEEE test network and simultaneous measurements on ad-hoc experimental benchmark power system are presented along with a discussion on the practical usability of such monitoring techniques.
Abstract only (2011)

The electricity network is undergoing a significant change towards a more adaptive, intelligent, self-managing, collaborative and information-driven grid. According to the smart grid vision, any electronic device connected to it will be able to communicate its consumed or produced energy almost in real time. Based on the analysis of this newly acquired information, a new generation of services and decision support systems can be realized, enabling more intelligent decisions, and ultimately a more efficient energy system. Therefore, high-performance acquisition of smart metering information from large scale distributed infrastructures is of key importance for the upcoming Internet-based enterprise services and mash-up applications. We have used open source software to build a web service-based advanced metering infrastructure of simulated smart meters, concentrators, and a smart metering platform, all interconnected via web services. We measure in a methodological fashion the performance of the various components of the architecture and evaluate their limitations. Finally we identify key performance indicators that need to be considered when deploying large-scale smart metering systems, and discuss on challenges and directions that arise.
Determination of conformational barriers in 1,5-cyclooctadiene by proton and carbon-13 nuclear magnetic resonance (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of conformational barriers in 1,5-cyclooctadiene by proton and carbon-13 nuclear magnetic resonanceF. A. L. Anet and Lech. KozerskiCite this: J. Am. Chem. Soc. 1973, 95, 10, 3407–3408Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/ja00791a068https://doi.org/10.1021/ja00791a068research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dopamine Receptor and Hypertension (2005)

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and/or impaired dopamine receptor function have been reported in hypertension. Disruption of any of the dopamine receptors (D(1), D(2), D(3), D(4), and D(5)) results in hypertension. In this paper, we review the mechanisms by which hypertension develops when dopamine receptor function is perturbed.