gebhart/patrepeval huggingface dataset:
Double‐tuned 31P/1H human head array with high performance at both frequencies for spectroscopic imaging at 9.4T (2020)

We developed a novel <sup>31</sup> P/<sup>1</sup> H double-tuned array for MR spectroscopic imaging of a human brain at 9.4T. Placing both <sup>31</sup> P and <sup>1</sup> H loops in a single layer provides for high transmit efficiency at both frequencies without compromising SNR near the brain center at the <sup>31</sup> P-frequency. Addition of the cross-loops at the superior location improves the brain coverage.
Novel Amperometric Biosensor Based on Tyrosinase/Chitosan Nanoparticles for Sensitive and Interference-Free Detection of Total Catecholamine (2022)

The regulation of nervous and cardiovascular systems and some brain-related behaviors, such as stress, panic, anxiety, and depression, are strictly dependent on the levels of the main catecholamines of clinical interest, dopamine (DA), epinephrine (EP), and norepinephrine (NEP). Therefore, there is an urgent need for a reliable sensing device able to accurately monitor them in biological fluids for early diagnosis of the diseases related to their abnormal levels. In this paper, we present the first tyrosinase (Tyr)-based biosensor based on chitosan nanoparticles (ChitNPs) for total catecholamine (CA) detection in human urine samples. ChitNPs were synthetized according to an ionic gelation process and successively characterized by SEM and EDX techniques. The screen-printed graphene electrode was prepared by a two-step drop-casting method of: (i) ChitNPS; and (ii) Tyr enzyme. Optimization of the electrochemical platform was performed in terms of the loading method of Tyr on ChitNPs (nanoprecipitation and layer-by-layer), enzyme concentration, and enzyme immobilization with and without 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as cross-linking agents. The Tyr/EDC-NHS/ChitNPs nanocomposite showed good conductivity and biocompatibility with Tyr enzyme, as evidenced by its high biocatalytic activity toward the oxidation of DA, EP, and NEP to the relative o-quinone derivatives electrochemically reduced at the modified electrode. The resulting Tyr/EDC-NHS/ChitNPs-based biosensor performs interference-free total catecholamine detection, expressed as a DA concentration, with a very low LOD of 0.17 μM, an excellent sensitivity of 0.583 μA μM<sup>-1</sup> cm<sup>-2</sup>, good stability, and a fast response time (3 s). The performance of the biosensor was successively assessed in human urine samples, showing satisfactory results and, thus, demonstrating the feasibility of the proposed biosensor for analyzing total CA in physiological samples.
Torque Ripple Minimization in Six-Step Modulated PMSM Drives via Fast DC Bus Dynamics (2018)

Six-step modulated drive systems have been shown to have higher power density and lower switching loss than pulse-width-modulation (PWM) drive systems. It has also been shown that by manipulating the dc bus voltage, six-step mode can drive permanent magnet synchronous machines (PMSMs) over a wide speed range, and maintain the machine operating point on the maximum torque per ampere (MTPA) curve below the base speed to reduce the machine copper loss. However, high torque ripple exists while in this type of six-step mode. This paper develops the control design methodologies to leverage fast dc bus manipulation, provided by 2-step finite-settling-step (FSS) dc-to-dc converter control, to minimize torque ripple in six-step PMSM drives. Two torque control algorithms: existing voltage angle-based torque control (VATC) and deadbeat-direct torque and flux control (DB-DTFC) are used to evaluate torque ripple reduction capability and energy savings potential of six-step PMSM drive systems.
FBMC Testbed with Frequency Domain Synchronization and Adaptive Bandwidth (2021)

To meet the ever growing demand of data rates, many modern wireless systems have adopted multicarrier modulation schemes. Nowadays, Orthogonal Frequency-Division Multiplexing (OFDM) is the most commonly used multicarrier modulation scheme that offers efficient use of bandwidth. To tackle intersymbol interference and avoid complex channel equalization, OFDM is usually used in combination with a Cyclic Prefix (CP). However, CP-OFDM comes with its own limitations such as the need of precise time and frequency synchronization, high out-of-band radiation as well high peak-to-average power ratio. Therefore, researchers have started investigating alternative multicarrier modulation schemes. Among others, Filter Bank Multicarrier (FBMC) is gaining a lot of attention due to its optimized prototype filters that eliminate the need of CP and reduce out-of-band radiation and, hence, offers further improvement in bandwidth utilization. In this work, we develop a Software Defined Radio (SDR) based FBMC testbed that operates in real time. We use GNU Radio as a software part of SDR in combination with Universal Software Radio Peripherals (USRPs) for over-the-air experiments. In contrast to state of the art, our FBMC transceiver exploits frequency domain synchronization and can easily be tuned for various bandwidths. By conducting over-the-air measurements, we show that the developed testbed can successfully be used even in presence of other narrowband systems in the same frequency bands. For the purpose of reproducibility, we make the testbed implementation also publicly available.
The effects of the intensity and duration of a masking stimulus, Δt, and signal duration on vibrotactile forward masking (1995)

Vibrotactile thresholds were found to increase as a function of the duration and intensity of a forward masking stimulus and to decrease as a function of the time interval between the termination of the masking stimulus and the onset of the signal (Δt) and signal duration. The effects of the intensity and duration of the masking stimulus were similar for both the P and NPI channels as indicated by the nearly identical results measured at 250 and 20 Hz. The observed declines in threshold as a function of Δt and signal duration were both attributed to an increase in the time interval between the offset of the masking stimulus and the offset of the signal.
Editorial Comment (2017)

No AccessJournal of UrologyAdult Urology1 Mar 2018Editorial Comment Benjamin T. Ristau and Alexander Kutikov Benjamin T. RistauBenjamin T. Ristau More articles by this author and Alexander KutikovAlexander Kutikov More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.09.163AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 199(3), pp. 639–640 References 1 : Understanding treatment disconnect and mortality trends in renal cell carcinoma using tumor registry data. Med Care2017; 55: 398. Google Scholar 2 : Renal mass and localized renal cancer: AUA guideline. J Urol2017; 198: 520. Link, Google Scholar 3 : Can looks deceive? Not all clinically “cystic” renal masses harbor indolent biology. J Urol2017; 197: e992. abstract PD52-08. Abstract, Google Scholar © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 199Issue 3March 2018Page: 639-640 Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benjamin T. Ristau More articles by this author Alexander Kutikov More articles by this author Expand All Advertisement PDF downloadLoading ...
Sildenafil Promotes Smooth Muscle Preservation and Ameliorates Fibrosis Through Modulation of Extracellular Matrix and Tissue Growth Factor Gene Expression After Bilateral Cavernosal Nerve Resection in the Rat (2011)

SIL treatment after BCNR activates genes related to SM preservation and downregulates genes related to fibrosis in the corpora cavernosa. These results provide a mechanistic justification for the use of SIL and other PDE5 inhibitors as protective therapy against corporal SM loss and fibrosis after radical prostatectomy.
A T-cell antigen atlas for meningioma: novel options for immunotherapy (2023)

Meningiomas are the most common primary intracranial tumors. Although most symptomatic cases can be managed by surgery and/or radiotherapy, a relevant number of patients experience an unfavorable clinical course and additional treatment options are needed. As meningiomas are often perfused by dural branches of the external carotid artery, which is located outside the blood-brain barrier, they might be an accessible target for immunotherapy. However, the landscape of naturally presented tumor antigens in meningioma is unknown. We here provide a T-cell antigen atlas for meningioma by in-depth profiling of the naturally presented immunopeptidome using LC-MS/MS. Candidate target antigens were selected based on a comparative approach using an extensive immunopeptidome data set of normal tissues. Meningioma-exclusive antigens for HLA class I and II are described here for the first time. Top-ranking targets were further functionally characterized by showing their immunogenicity through in vitro T-cell priming assays. Thus, we provide an atlas of meningioma T-cell antigens which will be publicly available for further research. In addition, we have identified novel actionable targets that warrant further investigation as an immunotherapy option for meningioma.
Molecular Mechanisms of Antifungal Resistance in Mucormycosis (2022)

Mucormycosis is one among the life-threatening fungal infections with high morbidity and mortality. It is an uncommon and rare infection targeting people with altered immunity. This lethal infection induced by fungi belonging to the Mucorales family is very progressive in nature. The incidence has increased in recent decades owing to the rise in immunocompromised patients. Disease management involves a multimodal strategy including early administration of drugs and surgical removal of infected tissues. Among the antifungals, azoles and amphotericin B remain the gold standard drugs of choice for initial treatment. The order Mucorales are developing a high level of resistance to the available systemic antifungal drugs, and the efficacy still remains below par. Deciphering the molecular mechanisms behind the antifungal resistance in Mucormycosis would add vital information to our available antifungal armamentarium and design novel therapies. Therefore, in this review, we have discussed the mechanisms behind Mucormycosis antifungal resistance. Moreover, this review also highlights the basic mechanisms of action of antifungal drugs and the resistance landscape which is expected to augment future treatment strategies.
An SDR-based prototype of spectrally precoded OFDM (2017)

Spectrally precoded OFDM is a recent approach that aims for the suppression of the OOB, as well as the in-band gap, emissions in OFDM systems. Theoretically, the technique shows High suppression of the OOB and the in-band gap emissions. Although, practically hardware impairments may limit the precoder's performance. Yet, this demonstration shows that despite the hardware impairments, implemented spectrally precoded OFDM generates emissions tens of decibels less than that of plain OFDM. Therefore, the demonstration proves that communications links are less vulnerable to interference coming from spectrally precoded OFDM signals than to interference coming from plain OFDM signals.
Effect of Pneumococcal Conjugate Vaccine on the Natural Antibodies and Antibody Responses Against Protein Antigens From Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in Children With Community-acquired Pneumonia (2016)

In spite of the differences that have been found on the level of natural antibodies, no effect from pneumococcal vaccination was observed on the rate of immune responses associated with community-acquired pneumonia against protein antigens from S. pneumoniae, H. influenzae and M. catarrhalis.
Seismic Solutions for Drilling - Real-time Pore-pressure Estimation Ahead of the Bit (2012)

Overpressure is one of the important drilling hazards seen globally. Estimates of overpressured zone locations and overpressure magnitudes have a direct impact on well drilling and completion. Formation pressures in a drilling location are estimated from seismic velocities by using rock-physics-based transforms that map formation velocities to pore pressures. Consequently, the accuracy of the estimated pore pressures depends both on the accuracy of the velocities and the transforms. We present a method that makes optimum use of seismic data and information obtained from the well being drilled to provide pore-pressure estimates ahead of the drill bit in real time. During the drilling process, adjustments are made to the rock-physics model based on Logging While Drilling (LWD) data calibrating the model to local overburden geology. Furthermore, we show that by using while-drilling checkshot information, integrated with surface seismic data, we can improve the velocity estimates ahead of the bit. Field study results from a Gulf of Mexico well show that combining these two measurements provides a significantly better pore-pressure estimate ahead of the bit compared with pre-drill predictions.
The end of denial architecture and the rise of throughput computing (2009)

Throughput-optimized processors, such as graphics processing units (GPUs) have scaled at historic rates in recent years, and continue to do so along a design trajectory that is largely unhindered by conventional dogmas and legacies. These processors recognize that two critical aspects of machine organization are key to performance: parallel execution and hierarchical memory organization. Conventional processors, which present an illusion of sequential execution and uniform, flat memory, find their performance increasing only slowly over time, and their evolution is at an end. In contrast, throughput processors embrace, rather than deny, parallelism and memory hierarchy to realize large performance and efficiency advantages. Throughput processors have hundreds of cores today and will have thousands of cores by 2015. They will deliver most of the performance, and most of the user value, in future computer systems. This talk will discuss some of the challenges and opportunities in the architecture and programming of future throughput processors, as it relates to the EDA world. First, CAD tools, flows, and methodologies are clearly crucial to the design of these processors, and these must adapt to support such designs. Second, in this changing landscape, CAD tools must need to evolve to run on throughput processors. In throughput processors, performance derives from the parallelism available from the plentiful arithmetic units, and efficiency derives from locality, overcoming restrictions stemming from communication bandwidth bottlenecks that dominate cost, performance, and power. This talk will discuss exploitation of parallelism and locality with examples drawn from the Imagine and Merrimac projects, from NVIDIA GPUs, and from three generations of stream programming systems.
Recent advances in Eurocopter's passive and active vibration control (2008)

This paper is about recent advances in Eurocopter’s research activities on passive and active vibration control systems. Emphasis is placed on the reduction of rotor-induced vibrations which is still one of the key challenges in helicopter dynamics. Both passive and active means for the reduction of vibrations are discussed. A short review of the rotor-induced vibration problem is given with a link to typical vibration characteristics of Eurocopter helicopters. The concepts and means to influence and control vibrations are outlined. The main focus of this paper is on recent advances on i) vibration control at the rotor, ii) vibration control at the transmission and iii) vibration control at the fuselage. In the section “vibration control at the rotor”, vibrations are attacked at their source – the rotor itself. Advanced passive and active rotor dynamic layouts are of interest. Here, a 5-bladed bearingless vs. 4bladed main rotor system on EC145 as well as an active flap rotor on the hingeless system of BK117 are discussed. For each system, key parameters of the design, data of the test configuration and test environment and in particular results on vibration reduction are presented. A substantial reduction of the exciting hub loads is achieved thus providing superior airframe vibration levels. In the section “vibration control at the transmission”, a new generation of pylon isolation system is presented. This passive system based on the SARIB principle combines advantages of efficiency, lightness, reliability and low cost design. This technology consists of a compact suspension and a flapping mass integrated in each gear box strut. It provides an important attenuation of the vibrations for all hub loads components and it was successfully tested in-flight. In the section “vibration control at the fuselage”, active anti-vibration control systems (AVCS) installed in the fuselage are presented. The systems rely on single-port active devices which are capable to generate inertia-based control forces which induce a secondary vibration field to compensate the vibration disturbance. Here, systems based on electromagnetic actuation technology for EC225 as well as Piezo-ceramic technology demonstrated on EC135 are presented.
Etude de deux glycoproteines d'enveloppe de l'herpesvirus de la maladie d'aujeszky (1990)

Des anticorps monoclonaux diriges contre les glycoproteines gi, ii, iii, gp50 et gp63 de l'herpesvirus de la maladie d'aujeszky ont ete isoles et leurs caracteristiques biologiques (pouvoir neutralisant, protection passive chez la souris. . . ) ont ete definies. Les resultats obtenus ont oriente les recherches vers l'utilisation, en depistage de la glycoproteine i comme marqueur specifique de l'infection des porcs, et pour la vaccination, de la glycoproteine gp50 comme proteines immunogene. Le gene de la glycoproteine gp50 a ete isole puis exprime dans des cellules eucaryotes. La dissection de cette proteine par des anticorps monoclonaux a permis de proposer une carte des domaines antigeniques de la molecule. Trois domaines ont ete identifies dont deux apparaissent jouer un role dans la penetration du virus dans les cellules. Un adenovirus recombinant exprimant le gene de la gp50 a ete construit. Il exprime des quantites importantes de gp50 in vitro. Injecte a des souris et a des lapins, le virus recombinant induit la synthese de titres en anticorps eleves contre la gp50 et protege une partie des animaux contre une epreuve virulente severe. Les travaux conduits sur la glycoproteine gi ont abouti a la mise au point d'une technique permettant de differencier les animaux vaccines par une souche n'exprimant pas la glycoproteine i des animaux infectes. Les caracteristiques de la reponse gi chez des animaux vaccines par une souche gi- puis infectes ont ete analysees. Elle apparait etroitement correlee aux titres en anticorps contre les proteines ii, giii et gp50 avant l'epreuve et au niveau d'excretion de la souche virulente apres l'epreuve virulente. Enfin, le gene de la glycoproteine gi a ete clone puis exprime dans des cellules eucaryotes, a des fins d'optimisation des techniques de depistage differentiel
AFS: Accurate, Fast, and Scalable Error-Decoding for Fault-Tolerant Quantum Computers (2022)

Quantum computers promise computational advantages for many important problems across various application domains. Unfortunately, physical quantum devices are highly susceptible to errors that limit us from running most of these quantum applications. Quantum Error Correction (QEC) codes are required to implement Fault-Tolerant Quantum Computers (FTQC) on which computations can be performed without encountering errors. Error decoding is a critical component of quantum error correction and is responsible for transforming a set of qubit measurements generated by the QEC code, called the syndrome, into error locations and error types. For the feasibility of implementation, error decoders must not only identify errors with high accuracy, but also be fast and scalable to a large number of qubits. Unfortunately, most of the prior works on error decoding have focused primarily only on the accuracy and have relied on software implementations that are too slow to be of practical use. Furthermore, these studies only look at designing a single decoder and do not analyze the challenges involved in scaling the storage and bandwidth requirements when performing error correction in large systems with thousands of qubits.In this paper, we present AFS, an accurate, fast, and scalable decoder architecture that is designed to operate in the context of systems with hundreds of logical qubits. We present the hardware implementation of AFS, which is based on the Union Find decoding algorithm and employs a three-stage pipelined design. AFS provides orders of magnitude higher accuracy compared to recent SFQ-based hardware decoders (logical error rate of 6&#x00D7;10<sup>&#x2212;10</sup> for physical error rate of 10<sup>&#x2212;3</sup>) and low decoding latency (42ns on average), while being robust to measurement errors introduced while extracting syndromes during the QEC cycles. We also reduce the amount of decoding hardware required to perform QEC simultaneously on all the logical qubits by co-designing the micro-architecture across multiple decoding units. Our proposed Conjoined-Decoder Architecture (CDA) reduces the storage overhead by 70% (10MB to 2.8MB). Finally, we reduce the bandwidth overheads required to transmit syndromes from the qubits to the decoders by exploiting the sparsity in the syndromes and compressing the data. Our proposed Syndrome Compression reduces the bandwidth requirement by 30x, on an average.
STRATEGIES FOR TRANSPLANTATION OF CADAVERIC KIDNEYS WITH CONGENITAL FUSION ANOMALIES (2001)

To our knowledge we present the initial case of transplantation of an L-shaped kidney. Cadaveric kidneys with congenital fusion anomalies may be transplanted successfully using various individual technical strategies based on the specific renal anatomy. As such, these kidneys may be used to maximize the increasingly inadequate donor pool.