gebhart/patrepeval huggingface dataset:
The β3‐adrenoceptor agonist SR58611A ameliorates experimental colitis in rats (2008)

Beta(3)-adrenoceptor agonists protect against experimental gastric ulcers. We investigated the effects of the beta(3)-adrenoceptor agonist SR58611A on 2,4-dinitrobenzene sulphonic acid-induced colitis in rats and analysed the expression of beta(3)-adrenoceptors in the colonic wall. SR58611A was administered orally (1-10 mg kg(-1)) for 7 days, starting the day before induction of colitis. Colitis was assessed by macroscopic and histological scores, tissue myeloperoxidase activity, interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) levels. Reverse transcription-polymerase chain reaction and immunohistochemical analysis were used to examine the expression of beta(3)-adrenoceptors. SR58611A significantly reduced the severity of colitis as well as the tissue levels of TNF-alpha, IL-1beta and IL-6. Colitis was associated with a decreased expression of beta(3)-adrenoceptor mRNA in the mucosal/submucosal layer of distal colon and this reduction was not affected by SR58611A. Immunohistochemical analysis revealed beta(3)-adrenoceptors within the muscularis externa, in myenteric neurons and nerve fibres and in the submucosa. beta(3)-Adrenoceptor immunoreactivity was decreased in inflamed tissues compared to controls, particularly in the myenteric plexus; this reduction was counteracted by SR58611A. Amelioration of experimental colitis by the selective beta(3)-adrenoceptor agonist SR58611A suggests that beta(3)-adrenoceptors may represent a therapeutic target in gut inflammation.
Yurii Reznikov 16 October 1953–8 October 2016 (2017)

Yurii Reznikov, a professor of physics, head of the Department of Crystals at the Institute of Physics, National Academy of Sciences of Ukraine, died on 8 October 2016 in Kyiv, Ukraine. Yuri was a ...
An implementation of interleaved microstrip motherboard routing in Multi-Gbps I/O channel margin improvement (2012)

This paper presents an interleaved routing method for motherboard microstrip routing in Multi-Gbps interfaces. The proposed method yields improved channel performance in terms of Eye Height(mV) and Eye Width(ps) margins. Of note is the more prominent improvement in topologies with longer transmission lines. This method enables greater routing flexibility using full microstrip transmission lines with the benefit of improved channel margins at 20 mils inter-pair spacing. More importantly, it allows for the more tightly spaced 15 mils interpair spacing to be utilized without jeopardizing overall channel margins. Ultimately, this translates into a cost saving benefit in line with recent platforms' sleek and thin form factor.
Theoretical spectra for narrow-band random PWM waveforms (1993)

Pulse-width-modulated (PWM) power electronics systems often produce objectionable acoustic noise at the PWM switching frequency and multiples of it. Subjectively this noise may be reduced by randomising the switching frequency, thereby spreading the acoustic energy over a wider bandwidth. The paper presents a theoretical basis for predicting the output spectra of PWM converters under these random switching conditions. The technique is developed for a DC chopper system where theoretical spectral bands can be compared with exact spectra obtained by direct Fourier transform methods, but is then extended to three-phase applications. The paper also discusses strategies for selecting random switching sequences to improve the noise dispersion while reducing the converter&apos;s complexity.
Highly Selective Catalytic Friedel – Crafts Acylation of Activated Aromatic Compounds Using the I2.DMF Complex as Catalyst (2008)

A novel method has been developped for synthesizing aryl ketones by means of I2-DMF mediated Friedel – Crafts acylation of aromatic substrates. The reaction is applicable to activated aromatic compounds. The present process is carried out under conditions involving minimal wastes and energy-consumption as compared to the use of molecular iodine. Keywords: I2-DMF, AlCI3-DMF, anisole, aromatic substrates, heteroaromatic substrates, Friedel-Crafts reaction
Three-column osteotomy surgery versus standard surgical management for the correction of adult spinal deformity: a cohort study (2015)

For severe ASD patients with high grade pelvic incidence (PI), pelvic tilt (PT), and PI/lumbar lordosis (LL) mismatch and who have subjected to spine surgeries more than twice before, 3-COS might be more effective than SSM in improving the clinical outcomes. However, due to the higher reoperation rate of 3-COS, SSM may be more appropriate than SSM for correcting the not serious ASD patients.
<title>Novel compressed image improving technique by blending a reference image</title> (1998)

A novel image improving algorithm for compressed image sequence by blending with reference images is presented. The reference image is defined as the high quality still image of the same scene. Compressed images are improved by blending the data directly with the reference image in both DCT and spatial domain. Amount of blending is controlled by the resemblance between the reference and the compressed image. Experiments conducted on the sequence of H.263 compressed image is presented. Prior information about compression technique is not required so this technique should be able to apply to other techniques as well.
The effect of high temperature exposure upon the performance of lithium ion cells (2003)

The effect of electrolyte type upon the resilience of lithium-ion cells to high temperature storage has been investigated in experimental MCMB carbon-Li/sub x/Ni/sub y/Co/sub 1-y/O/sub 2/ three-electrode cells. A number of electrolytes have been studied where the solvent mixtures have been varied, with the intention of determining the impact of ethylene carbonate (EC)-content upon performance, as well as, the presence of nonconventional linear carbonates (ie., di-2,2,2-trifluoroethyl carbonate and dipropyl carbonate). In addition to determining the reversible and irreversible capacity losses sustained as a result of high temperature storage (55/spl deg/ to 70/spl deg/C), a number of electrochemical measurements (AC impedance, Tafel polarization and linear polarization) have been performed to determine the impact of the high temperature exposure upon the electrode kinetics and the nature of the electrode surface films. It was observed that cells containing electrolytes with high EC-content (>50% EC by volume) displayed superior resilience to high temperature storage, in contrast to cells containing low EC-content electrolytes (<25% EC by volume) which displayed much larger irreversible capacity losses and poorer lithium intercalation/deintercalation kinetics after exposure to high temperatures.
Height estimation improvement via baseline calibration for a dual-pass dual-antenna ground-mapping IFSAR system (2003)

Data collection for interferometric synthetic aperture radar (IFSAR) mapping systems currently utilize two operation modes. A single-antenna, dual-pass IFSAR operation mode is the first mode in which a platform carrying a single antenna traverses a flight path by the scene of interest twice collecting data. A dual-antenna, single-pass IFSAR operation mode is the second mode where a platform possessing two antennas flies past the scene of interest collecting data. There are advantages and disadvantages associated with both of these data collection modes. The single-antenna, dual-pass IFSAR operation mode possesses an imprecise knowledge of the antenna baseline length but allows for large antenna baseline lengths. This imprecise antenna baseline length knowledge lends itself to inaccurate target height scaling. The dual-antenna, one-pass IFSAR operation mode allows for a precise knowledge of the limited antenna baseline length but this limited baseline length leads to increased target height noise. This paper presents a new, innovative dual-antenna, dual-pass IFSAR operation mode which overcomes the disadvantages of the two current IFSAR operation modes. Improved target height information is now obtained with this new mode by accurately estimating the antenna baseline length between the dual flight passes using the data itself. Consequently, this new IFSAR operation mode possesses the target height scaling accuracies of the dual-antenna, one-pass operation mode and the height-noise performance of the one-antenna, dual-pass operation mode.
Large system error probability of multiuser decision feedback receivers (2002)

The large system limits of the probability of error for multiuser decision feedback detectors (DFDs) are evaluated for synchronous CDMA. Both successive (S-) and parallel (P-) DFDs are considered, where the filters are optimized according to the minimum mean squared error (MMSE) criterion. A comparison of the analytical results with simulation shows that the large system results accurately predict the performance of systems with a spreading gain /spl ges/128 over a wide range of error rates. The results also show that the P-DFD error rate approaches the single-user bound at high signal-to-noise-ratios (SNRs).
Forced vaporization cooling of HVDC thyristor valves. Final report (1982)

No significant differences in DFS were observed between three centers with different surgical approaches to ALND based on different TTL cut-offs in patients with BC after NAST. These results suggest that restricting ALND to those patients with TTL ≥ 15,000 copies/μL is a reliable approximation, avoiding unnecessary morbidities caused by ALND.
Deep ultraviolet light generation at 266 nm by quasi-phase-matched quartz (2007)

We demonstrated the finest twin structure ever reported in crystal quartz with a period of 17.8 μm. Second harmonic 266 nm light of 0.10 mW was obtained by the third-order QPM in quartz, from a ns-pulsed doubled Nd:YVO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> .
Automated DWI analysis can identify patients within the thrombolysis time window of 4.5 hours (2018)

An automated analysis of DWI performs at least as good as the visual DWI-FLAIR mismatch in selecting patients within the 4.5-hour time window.
Property improvement of flat-top 50GHz-88ch arrayed waveguide grating using phase correction waveguides (2010)

We have proposed a novel circuit design with the phase correction waveguides in part of the arrayed waveguides to improve the property of an AWG with a narrow spacing and a large channel count without the additional processes such as a UV trimming method. Employing this novel circuit design, we have successfully demonstrated a flat-top 50GHz-88ch with a low crosstalk experimentally.
Comparison of BCR-ABL1 quantification in peripheral blood and bone marrow using an International Scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia (2020)

Background Monitoring of molecular response (MR) using quantitative polymerase chain reaction (PCR) for BCR-ABL1 is a pivotal tool for guiding tyrosine kinase inhibitor therapy and the long-term follow-up of patients with chronic myeloid leukemia (CML). Results of MR monitoring are standardized according to the International Scale (IS), and specific time-dependent molecular milestones for definition of optimal response and treatment failure have been included in treatment recommendations. The common practice to use peripheral blood (PB) instead of bone marrow (BM) aspirate to monitor the MR monitoring in CML has been questioned. Some studies described differences between BCR-ABL1 levels in paired PB and BM specimens. Methods We examined 631 paired PB and BM samples from 283 CML patients in a retrospective single-center study using an IS normalized quantitative reverse transcription (qRT)-PCR assay for quantification of BCR-ABL1IS. Results A good overall concordance of BCR-ABL1IS results was found, a systematic tendency towards higher BCR-ABL1IS levels in PB was observed in samples of CML patients in a major MR. This difference was most pronounced in patients treated with imatinib for at least 1 year. Importantly, the difference resulted in a significantly lower rate of deep MR when BCR-ABL1IS was assessed in the PB compared to BM aspirates. Conclusions In summary, our data suggest that the classification of deep MR in patients with CML is more stringent in PB than in BM. Our study supports the current practice to primarily use PB for long-term molecular follow-up monitoring in CML.
Elimination of stress-induced voids on AlCu multilevel interconnect lines (1993)

Multilevel metal (MLM) structures utilizing four layers of large grain size Al 1.5% Cu metallization have displayed `in process' stress voiding in metal layers two through four upon completion of final passivation and anneal. Changing the deposited dielectric stress from 2E8 dynes/cm<SUP>2</SUP> to a slightly more compressive 1.25E9 dynes/cm<SUP>2</SUP> eliminated the formation of `in process' stress voids. However, thermal stressing at 200 degree(s)C still produced stress voiding in metal layers two and three. The addition of a 125 angstrom TiW cap to the second, third, and fourth metal layer was shown to eliminate both `in process' stress voids and long term 200 degree(s)C thermal stress induced metal line voids on all material with standard dielectric thicknesses. The results comparing various dielectric stress levels and metal structures with and without a TiW cap are reported here.
HDR video super-resolution for future video coding (2018)

New coding tools are emerging in Future Video Coding (FV C). A novel video coding system, which combines FVC-era coding tools with super-resolution is proposed, aiming to demonstrate the state of the art coding results in ultra-high definition video coding. Experimental results show the proposed system outperforms convention system in both SDR and HDR images.
Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial (2022)

NCT04315298.
Coating: Effect of base paper grammage and electrolyte content on electrical and dielectric properties of coated papers (2010)

The effects of base paper grammage and sodium chloride (NaCl) content in the base paper prior to pigment coating were studied with regard to the electrical and dielectric properties of the coated paper. The results reveal not only the effect of the base paper but also the role of base paper-coating interaction. The surface and volume conductivities were dependent on the coat weight, but this dependence was influenced by both base paper ion content and grammage. The potential half decay and the real part of the dielectric constant increased with increasing coat weight. By gradually changing the ion content of the base paper and thus the surface and volume conductivities, we were able to change the electrical and dielectric properties of the coated papers and hence demonstrate different ion-induced effects.
Amorphous (2016)

This Glossary of Terms Related to Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drugmaking process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline, such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general; and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.
Effect of a Combination of Lysolecithin, Synthetic Emulsifier and Monoglycerides on the Apparent Ileal Digestibility, Metabolizable Energy and Growth Performance of Growing Pigs (2022)

Two studies were conducted to determine the impact of an absorption enhancer containing a combination of lysophospholipids, monoglycerides and synthetic emulsifiers (LEX) on apparent ileal digestibility, metabolizable energy (ME), and growth performance of growing pigs. In the digestibility study, 12 male crossbred [Duroc x (Large White x Landrace)] pigs with an initial body weight (BW) of 30 kg were randomly allocated to two dietary treatments: (1) a positive control (PC) receiving standard diets formulated to 3100 kcal ME/kg, and (2) a negative control formulated with −100 kcal ME/kg and −2.5% AA content vs. PC and supplemented with LEX at 500 g/t. Apparent ileal digestibility of essential AA was significantly increased for lysine, methionine, threonine, histidine, isoleucine and phenylalanine in the LEX treatment (p < 0.05). Average uplift in AA digestibility as a percent of the PC was +1.88%; with greatest improvement for histidine (+4.22%). LEX supplementation effectively compensated energy deficiency of low-density diet and provided additional ME improvement compared to the PC diet (p < 0.05). A second study was conducted to evaluate LEX dose response on the growth performance of pigs fed a low nutrient density diet. Total 450 cross-bred pigs (240 males (castrated) and 210 females) [Duroc x (Large White x Landrace)] with an average initial BW of 7.19 kg were randomly allocated into 4 dietary treatments: (1) a positive control (PC) formulated with standard specifications, (2) a negative control formulated with −100 kcal ME/kg and −2.5% AA content vs. the PC (NC), (3) NC + LEX at 250 g/t (NC + 250) and (4) NC + LEX at 500 g/t (NC + 500). Results showed significant improvement with LEX supplementation on the final BW, average daily gain (ADG) and feed conversion ratio (FCR) of pigs of >50 kg body weight. Across the study, NC + 500 significantly increased ADG vs. PC and NC, and significantly reduced FCR compared to all other treatments. FCR of negative control diets improved by 9 and 15 points with the supplementation of 250 g/t and 500 g/t of LEX, respectively (p < 0.05). FCR in the NC + 250 diet was statistically similar vs. PC, which was significantly reduced compared to the NC. Taken together, these studies demonstrate that the addition of an absorption enhancer containing a combination of lysophospholipids, monoglycerides and synthetic emulsifiers can improve growth performance in growing pigs, driven by increased nutrient digestibility and retention.
Optimization Vector Quantization by Adaptive Associative-Memory-Based Codebook Learning in Combination with Huffman Coding (2010)

In the presented research on codebook optimization for vector quantization, an associative memory architecture is applied, which searches the most similar data among previously stored reference data. For realizing the learning function of new codebook data, a learning algorithm is implemented, which is based on this associative memory and which imitates the concept of the human short/long-term memory. The quality improvement of the codebook for vector quantization, created with the proposed learning algorithm, and the learning-parameter dependence of the improvement is evaluated with the Peak Signal Noise Ratio (PSNR), which is an index of the image quality. A quantitative PSNR improvement of 2.5 - 3.0 dB could be verified. Since the learning algorithm orders the codebook elements according to their usage frequency for the vector-quantization process, Huffman coding is additionally applied, and is verified to further improve the compression ratio from 12.8 to 14.1.
Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: observational study using prospectively collected registry data (2021)

ClinicalTrials.gov NCT01090362.
A Novel Interface for Audio Search (2006)

In this paper a novel cyclic interface for searching through a song database is proposed. The method, which merges multiple audio streams on a server and broadcasts only a single merged stream, allows the user to hear different parts of each audio stream by cycling through all available streams. Experimental results on 21 users illustrate that the proposed interface requires less listening time as compared to traditional list-based interfaces when the desired song/audio clip is among one of the audio streams. The average search time for the proposed interface was 7.3 seconds, compared to 12.1 seconds for the traditional list-based interface when searching for a song which is included among the audio streams
Density of grammar forms part II (1986)

In the second part of this paper we give two characterizations for dense intervals consisting of grammatical families. By means of the characterizations it is proved that denseness is undecidable for context-free forms. On the other hand, denseness turns out to be decidable if the two languages, generated by the forms that define the interval in question, are known to be regular. The characterization theorems also enable us to investigate the maximality of dense intervals. We demonstrate that every such interval containing families with infinite languages can be extended from below while retaining density. The notion of a language form is used as a basic auxiliary concept in our argumentation.
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads (2011)

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.
<i>FACS</i> analysis for mesothelin and CA125 expressions in A431 and A549 cell lines. (2015)

&lt;p&gt;Cells were incubated with the indicated primary antibodies or isotope control antibodies, and appropriate secondary antibody (goat anti-mouse IgG, R-PE or goat anti-mouse, FITC). Results are shown as histogram plots for binding of primary antibody (black trace) or isotype control (gray trace). A431 cells are negative for both MSLN and CA125. A549 cells show low mesothelin expression (3.5×10&lt;sup&gt;3&lt;/sup&gt; sites/cell) but highly express CA125.&lt;/p&gt;