gebhart/patrepeval huggingface dataset:
Two-dimensional simultaneous subpixel estimation for area-based matching (2005)

Area-based matching is a fundamental image processing operation to obtain the displacement between images. Also, the similarity interpolation method to estimate subpixel displacement is commonly used to enhance resolution. Conventionally, similarity interpolation estimation is performed by assuming that the horizontal and vertical displacements are independent. Almost no investigations of estimation error over the conventional method have been made, but it is inferred experientially that subpixel estimation with image interpolation or gradient-based methods is more precise than the similarity interpolation method. This paper proposes a novel 2D subpixel displacement estimation method based on similarity interpolation through modeling of 2D self-similarity. The proposed method requires no “a priori” knowledge of 2D similarity and no images at all. It adopts no iteration. Furthermore, the proposed method entails only slightly higher calculation costs than the conventional similarity interpolation method. The proposed method can obtain more precise estimation than both the conventional similarity interpolation method and the image interpolation method using comparison of subpixel estimation accuracy. An experiment using actual images demonstrates the effectiveness of the proposed method. © 2005 Wiley Periodicals, Inc. Syst Comp Jpn, 36(2): 1–11, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/scj.20221
Data from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate (2023)

&lt;div&gt;Abstract&lt;p&gt;Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microscopy of cancer and normal cell lines, we find that a novel K5I causes several different cancer and noncancer cell types to undergo prolonged arrest in monopolar mitosis. Subsequent events, however, differed greatly between cell types. Normal diploid cells mostly slipped from mitosis and arrested in tetraploid G&lt;sub&gt;1&lt;/sub&gt;, with little cell death. Several cancer cell lines died either during mitotic arrest or following slippage. Contrary to prevailing views, mitotic slippage was not required for death, and the duration of mitotic arrest correlated poorly with the probability of death in most cell lines. We also assayed drug reversibility and long-term responses after transient drug exposure in MCF7 breast cancer cells. Although many cells divided after drug washout during mitosis, this treatment resulted in lower survival compared with washout after spontaneous slippage likely due to chromosome segregation errors in the cells that divided. Our analysis shows that K5Is cause cancer-selective cell killing, provides important kinetic information for understanding clinical responses, and elucidates mechanisms of drug sensitivity versus resistance at the level of phenotype. [Mol Cancer Ther 2008;7(11):3480–9]&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: REARRANGEMENTS OF BICYCLO(3,2,0)HEPTAN‐6‐ONES, SYNTHESIS OF POTENTIAL PROSTANOID PRECURSORS (1975)

Abstract Das Bicycloheptenon (I) reagiert mit N‐Brom‐acetamid (II) in Methanol, Benzylalkohol oder wäßrigem Aceton zu den Bromäthern (IIIa) bzw. (IIIb) bzw. zu dem Bromhydrin (IIIc).
Multiagent Work Practice Simulation: Progress and Challenges (2002)

Modeling and simulating complex human-system interactions requires going beyond formal procedures and information flows to analyze how people interact with each other. Such work practices include conversations, modes of communication, informal assistance, impromptu meetings, workarounds, and so on. To make these social processes visible, we have developed a multiagent simulation tool, called Brahms, for modeling the activities of people belonging to multiple groups, situated in a physical environment (geographic regions, buildings, transport vehicles, etc.) consisting of tools, documents, and a computer system. We are finding many useful applications of Brahms for system requirements analysis, instruction, implementing software agents, and as a workbench for relating cognitive and social theories of human behavior. Many challenges remain for representing work practices, including modeling: memory over multiple days, scheduled activities combining physical objects, groups, and locations on a timeline (such as a Space Shuttle mission), habitat vehicles with trajectories (such as the Shuttle), agent movement in 3D space (e.g., inside the International Space Station), agent posture and line of sight, coupled movements (such as carrying objects), and learning (mimicry, forming habits, detecting repetition, etc.).
On conditions for constant throughput in wireless networks (2006)

In this article we propose a set of necessary and sufficient conditions under which the long-term averaged throughput in an ad hoc network can remain constant as the number of nodes n increases. Throughput refers to the minimum achievable rate between a source-destination pair for a given routing mechanism and physical model, when the network is shared by Θ( n ) randomly chosen source-destination pairs. The main idea is to use a connectivity graph , which does not represent the actual physical network but rather the available communication resources. This graph also allows one to translate the problem of maximizing the throughput in ad hoc networks to the multicommodity flow problem and directly apply related results.
ELECTRON COOLING STATUS AND CHARACTERIZATION AT FERMILAB'S RECYCLER* (2007)

FNAL's electron cooler (4.3 MV, 0.1 A DC) has been integrated to the collider operation for almost two years, improving the storage and cooling capability of the Recycler ring (8 GeV antiprotons). In parallel, efforts are carried out to characterize the cooler and its cooling performance. This paper discusses various aspects of the cooler performance and operational functionality: high voltage stability of the accelerator (Pelletron), quality of the electron beam generated, operational procedures (off-axis cooling, electron beam energy measurements and calibration) and cooling properties (in the longitudinal and transverse directions).
ChemInform Abstract: A Convenient Synthesis of 1‐Alkyl‐4‐oxo‐1,4‐dihydrocinnolines. (1987)

Abstract The title compounds (IV) are prepared by reaction of the 4‐oxo‐3‐triphenylphosphoranylidene‐3,4‐dihydrocinnolines (I) with an excess of the alkyl halides (II) and subsequent hydrolysis with sodium hydroxide.
Contrasting pharmacodynamic requirements of disease models revealed through characterization of a novel and selective M1 agonist (2013)

A new class of selective M1 muscarinic allosteric agonists has emerged. Reported here, is the in vitro and in vivo characterization of a novel M1 agonist, PPBI, a new member of that family and the clear demonstration that the biological effects of PPBI are mediated through M1. PPBI reverses d‐amphetamine locomotor activity, but fails to do so in transgenic mice that do not express M1. At much lower doses, PPBI reverses a natural deficit in a rat cognition model, occurring at an exposure level which is also shown to activate cortical circuitry as measured by phMRI. Most importantly, PPBI is analgesic in a variety of rat and mouse models and the analgesic effect of PPBI is reversed by an M1‐preferring antagonist and an M1‐selective toxin. Finally, the pharmacokinetic/pharmacodynamic measures of this highly characterized tool are compared across multiple endpoints and it is concluded that models of psychosis and pain require greater M1 receptor activation by PPBI than that required in the cognition model.
BRCA1 Mediated Homologous Recombination and S Phase DNA Repair Pathways Restrict LINE-1 Retrotransposition in Human Cells (2019)

Abstract Long interspersed element-1 (LINE-1 or L1) is the only autonomous retrotransposon active in human cells. L1s DNA makes about 17% of the human genome and retrotransposition of a few active L1 copies has been detected in various tumors, underscoring the potential role of L1 in mediating or increasing genome instability during tumorigenic development. Different host factors have been shown to influence L1 mobility through several mechanisms. However, systematic analyses of host factors affecting L1 retrotransposition are limited. Here, we developed a high-throughput microscopy-based retrotransposition assay and coupled it to a genome-wide siRNA knockdown screen to study the cellular regulators of L1 retrotransposition in human cells. We showed that L1 insertion frequency was stimulated by knockdown of Double-Stranded Break (DSB) repair factors that are active in the S/G2 phase of the cell cycle including Homologous Recombination (HR), Fanconi Anemia (FA) and, to a less extent, microhomology-mediated end-joining (MMEJ) factors. In particular, we show that BRCA1, an E3 ubiquitin ligase with a key role in several DNA repair pathways, plays multiple roles in regulating L1; BRCA1 knockdown directly affects L1 retrotransposition frequency and structure and also plays a role in controlling L1 ORF2 protein translation through L1 mRNA binding. These results suggest the existence of a “battle” between HR factors and L1 retrotransposons, revealing a potential role for L1 in development of tumors characterized by BRCA1 and HR repair deficiencies.
An alternative process for solid state power amplifiers using large S parameters (2002)

A new method related to power amplifier design is described in this paper. Whereas linear amplifiers require only resolving the double matching problem, designing power amplifiers leads to setting up an accurate method allowing achievement of optimum performance from the transistors. Based on large signal S parameters, defined as function of the input power and of the frequency, this approach gives a very close approximation of the optimum source and load impedances to present to the active circuit for maximum added power. Designing microwave multistage power amplifiers, with the help of numerical approach and optimization routine, can then be considered. An example is given with a single stage at 5.9 GHz.
Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075 (2016)

The ability of BET family inhibitor ABBV-075 to inhibit transcription activation downstream of the initiating events of transcription factors like AR and TMPRSS2:ETS fusion proteins provides a promising therapeutic option for CRPC patients who have developed resistance to second-generation antiandrogens. Mol Cancer Res; 15(1); 35-44. ©2016 AACR.
[Au25(SR)18]22−: a noble metal cluster dimer in the gas phase (2016)

We present the first example of dimer formation in the monolayer protected atomically precise cluster system, Au25(SR)18, using ion mobility mass spectrometry. These transient species are shown to be important in explaining chemical reactivity between clusters.
Conjugated Microporous Poly(aryleneethynylene) Networks (2007)

Rigid wiry nets: Conjugated microporous polymer networks are formed by Sonogashira–Hagihara coupling. Although these materials are amorphous, the micropore size and surface area can be controlled by varying the length of the phenyleneethynylene struts (see picture; the network is shown in blue, and one 1,3,5-substituted benzene node and three connected struts are highlighted with C gray and H white).
Revealing the causative variant in Mendelian patient genomes without revealing patient genomes (2017)

Abstract Given the rapidly growing utility of critical health information revealed in the human genome, secure genomic computation is essential to moving forward, especially as genome sequencing becomes commonplace. We devise and implement proof-of-principle computational operations for precisely identifying causal variants in Mendelian patients using secure multiparty computation methods based on Yao’s protocol. We show multiple real scenarios (small patient cohorts, trio analysis, two hospital collaboration) where the causal variant is discovered jointly, while keeping up to 99.7% of all participants’ most sensitive genomic information private. All similar operations performed today to diagnose such cases are done openly, keeping 0% of participants’ genomic information private. Our work will help usher in an era where genomes can be both utilized and truly protected.
Fourier transform analysis: Nonlinear dynamic response of an electrorheological material (1993)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Daniel R. Gamota, Alan S. Wineman, Frank E. Filisko; Fourier transform analysis: Nonlinear dynamic response of an electrorheological material. J. Rheol. 1 September 1993; 37 (5): 919–933. https://doi.org/10.1122/1.550403 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
A 12-nm Autonomous Driving Processor With 60.4 TOPS, 13.8 TOPS/W CNN Executed by Task-Separated ASIL D Control (2021)

This article proposes an automotive safety integrity level (ASIL) D, which is the highest automotive integrity level specified in ISO 26262, and a target application processor for driving automation systems with a high convolutional neural network (CNN) processing performance of 60.4 trillion operations per second (TOPS) with high power efficiency of 13.8 TOPS/W. To achieve both performance and power efficiency, a stream processing architecture specialized for CNN hardware module is adopted to implement many low-power arithmetic units. In addition, 6 MB of local memories are implemented to reduce data transfers between dynamic random access memory (DRAM) and the CNN hardware, thereby improving the execution efficiency of the arithmetic units and saving power consumption caused by the data transfer. In order to support high safety integrity level with power efficiency, we provide safety mechanisms with high failure detection rates only for the hardware used in applications that require ASIL D support. The configuration of two CNN modules can switch between lockstep and single operation depending on the use case, thus achieving a tradeoff between performance and ASIL while maintaining power efficiency. In addition, the freedom from interference (FFI) concept defined in ISO 26262 is achieved by providing mechanisms to prevent low safety level tasks from interfering with high safety level tasks running concurrently inside the processor.
Response assessment in lymphoma: Concordance between independent central review and local evaluation in a clinical trial setting (2016)

A limited independent review audit strategy for clinical trials of some lymphomas appears feasible and practical based on substantial concordance in assessments of overall objective response by central and local evaluation in two international, prospective, registration trials in lymphoma. Some variability between assessors in the time-to-event endpoints was observed, which appeared attributable to earlier assignments of progression by independent central review compared with local evaluation.
Understanding the Activity and Stability of Single-Atom Catalysts for the ORR in Anion Exchange Membrane Fuel Cell(AEMFCs) (2021)

To be considered the ultimate power source for transportation systems and portable devices, anion exchange membrane fuel cells (AEMFCs) need to overcome significant cost barriers1,2. For this, the U.S. Department of Energy (DOE) recently has set some challenging activity targets for AEMFCs; this includes the near-term target PGM loading is 0.2 mg/cm2 for 2021–2023, and by 2024 the total loading should be limited to ⩽ 0.125 mg/cm2.This final milestone is the first step in enabling a shift to completely platinum group metal (PGM)-free membrane electrode assemblies (MEAs) by 20303. Unfortunately, today's high performing4 and long-life5,6 MEAs all rely on a high loading of PGM in both the anode and the cathode, resulting in a total PGM loading of ~1 mgPGM/cm2.
Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism (2011)

These findings demonstrate that nanoparticle-based delivery of siRNAs directed at critical targets such as DCAMKL-1 may provide a novel approach to treat cancer through the regulation of endogenous miRNAs.
Waveform design and receive processing for nonrecurrent nonlinear FMCW radar (2015)

A spectral shaping optimization scheme is used to design the autocorrelation response of individual segments of a nonrecurrent nonlinear FMCW waveform denoted as Pseudo-Random Optimized FMCW (or PRO-FMCW). Because each waveform segment is unique, the range sidelobes do not combine coherently during Doppler processing thereby providing further sidelobe suppression. The PRO-FMCW waveform can be viewed as a specific instantiation of FM noise radar where the constant amplitude permits maximum power efficiency. A segmented approach to processing the received data is used to reduce processing time and complexity. Measured results from hardware implementation are provided to demonstrate the efficacy of the proposed approach.
4D MR-PET der Lunge: Effekte der Atmungsbewegungskorrektur der PET durch eine self-gated MR-VIBE auf die Rundherddetektion im belüfteten Phantom (2017)

Für die Thoraxorgane führt die Akquisition des PETs in freier Atmung zu einer unscharfen Ortsrekonstruktion und damit zu einer Unterschätzung der rekonstruierten Aktivität und einer Überschätzung des Läsionsvolumens. Ziel der Studie war die Quantifizierung des Einflusses der Atmungsbewegungsartefakte mittels einer MR-PET-basierten Bewegungskorrektur.
Theranostics in Oncology—Thriving, Now More than Ever (2021)

Tracing its roots back to the 1940s, theranostics in nuclear oncology has proved successful mainly due to the beneficial effects of image-guided therapeutic concepts for patients afflicted with a variety of different cancers. The majority of these treatments are not only characterized by substantial prolongation of progression-free and overall survival, but are also generally safe, rendering theranostic agents as an attractive treatment option in various clinical scenarios in oncology. In this Special Issue <i>Novel Theranostic Agents</i>, nine original articles from around the globe provide further evidence on the use of the theranostic concept for neuroendocrine neoplasm (NEN), prostate cancer (PC), meningioma, and neuroblastoma. The investigated diagnostic and therapeutic radiotracers target not only established structures, such as somatostatin receptor, prostate-specific membrane antigen or norepinephrine transporter, but also recently emerging targets such as the C-X-C motif chemokine receptor 4. Moreover, the presented original articles also combine the concept of theranostics with in-depth read-out techniques such as radiomics or novel reconstruction algorithms on pretherapeutic scans, e.g., for outcome prediction. Even 80 years after its initial clinical introduction, theranostics in oncology continues to thrive, now more than ever.
3D visualization of aurora from optional viewpoint at optional time (2015)

Three-dimensional analysis of the aurora is significant because the shape of aurora depends on solar wind which influences electric equipment such as satellites. Our research group set two fish-eye cameras in Alaska, U.S.A and reconstructed the Aurora's shape from a pair of stereo images [Fujii et al. 2014]. However, the method using the feature-based matching cannot detect dense enough feature points accurately since they are hard to detect from the aurora image whose most parts are with low contrast. In this paper, we achieved both increasing the detected feature points and improving accuracy. Applying this method, the 3D shape of aurora from optional view point at optional time can be visualized.
Low complexity hybrid analog/digital phased array for ad-hoc networks (2012)

This paper investigates a hybrid analog/digital beam former (ADBF). Traditional analog beam formers (ABF) steer a single beam using a single transceiver, power splitter/combiner, and electronically controlled analog phase shifters. In contrast modern digital beam formed arrays (DBF) or `smart antennas' use separate transceiver chains, A/D and D/A converters, and DSPs. This enables direct digital control of array weights to optimize criteria such as mean square error (MSE) or signal-to-interference ratio (SIR) in real time. DBF technologies are effective but are not suitable for every application due to their relative high cost and complexity. The technique proposed here is similar to ADBF approaches using a single transceiver and analog phase shifters, but phase shifters are digitally controlled to provide flexible multiple nulls and beams defined in real time.
Silica-based waveguide-type 16 x 16 optical switch module incorporating driving circuits (2003)

We developed a 16/spl times/16 optical matrix switch module in which we incorporated a silica-based thermooptic switch chip and driving circuits. The module exhibited excellent levels of performance, namely a low insertion loss and a high extinction ratio. This is the largest scale waveguide-type matrix switch module yet reported. Driving circuits with a serial-to-parallel control signal conversion function enabled us to realize a new module structure that is both simple and flexible for use with larger scale switches.
Molecular Mechanisms of LLLT (2018)

<strong>3.1 Chromophores</strong> <strong>3.1.1 Cytochrome c oxidase</strong> Cytochrome c oxidase (CCO) is the terminal enzyme of the electron transport chain that mediates the electron transfer from cytochrome c to molecular oxygen. Several lines of evidence show that CCO acts as a photoacceptor and transducer of photosignals in the red and NIR regions of the light spectrum. It seems that LLLT increases the availability of electrons for the reduction of molecular oxygen in the catalytic center of CCO, which increases the mitochondrial membrane potential (MMP) and the levels of ATP, cAMP, and ROS, as well. LLLT increases the activity of complexes I, II, III, and IV, and succinate dehydrogenase in the electron transfer chain. CCO is known as complex IV and, as mentioned before, appears to be the primary photoacceptor. This assumption is supported by the increased oxygen consumption during low-level light irradiation (the majority of the oxygen consumption of a cell occurs at complex IV in the mitochondria) and by the fact that sodium azide, a CCO inhibitor, prevents the beneficial effect of LLLT. Besides ATP and cAMP, the nitric oxide (NO) level is increased, either by being released from metal complexes in CCO (CCO has two heme and two copper centers) or by up-regulation of the activity of CCO as a nitrite reductase.