gebhart/patrepeval huggingface dataset:
Composite Material Testing Data Reduction to Adjust for the Systematic 6-DoF Testing Machine Aberrations (2012)

This paper describes a data reduction methodology for eliminating the systematic aberrations introduced by the unwanted behavior of a multiaxial testing machine, into the massive amounts of experimental data collected from testing of composite material coupons. The machine in reference is a custom made 6-DoF system called NRL66.3 and developed at the NAval Research Laboratory, that consists of multiple sets of hexapod configurations essentially forming a recursive synthesis of multiple parallel mechanisms. Hexapod linkages, the grips, and other deformable parts of the machine absorb energy. This is manifested in an either reversible or irreversible manner, thus introducing a parasitic behavior that is undesirable from the perspective of our ultimate goal of the material constitutive characterization. The data reduction focuses both on the kinematic (pose of the grip) and the reaction (forces and moments) that are critical input quantities of the material characterization process. The kinematic response is reduced by exploitation of the kinematics of the dots used for full field measurements. A correction transformation is identified by solving an inverse problem that minimizes the known displacements at the grips as given by the full field measurements and those given by the machine’s displacement sensors. A Procrustes problem formalism was introduced to exploit a known material behavior tested by the testing machine. Consequently, a correction transformation was established and was applied on the load cell data of the machine in order to eliminate the spurious responses appearing in the force and moment data.
A Microfluidics Approach to the Problem of Creating Separate Solution Environments Accessible from Macroscopic Volumes (2004)

We report on a microfluidic device that generates separate solution environments in macroscopic volumes. Spatially distinct patterns are created by emitting fluids from 16 different sources (closely spaced microchannels) into a solution-filled macroscopic chamber. The fluid in neighboring microchannels couples viscously in the macroscopic container, generating one single interdigitated stream. Scanning nanoelectrode amperometry was used for characterizing the concentration landscape and the diffusion zones between solutions running in parallel at different coordinates in the stream. These experiments were complemented by finite element simulations of the Navier-Stokes and mass transport equations to describe the velocity distributions and the diffusion behavior. For in channel flow velocities of 50 mm.s(-1), patterns could persist on the order of millimeters to centimeters in the open volume. The most narrow diffusion zones with widths less than 10 microm (5-95% concentration change) were found some tens of micrometers out in the macroscopic container. We demonstrate that a 14-microm-diameter nearly spherical object (biological cell) attached to a micropipet can be moved from one solution environment to another by a lateral displacement of only 8 microm. The device is suitable for applications where the solution environment around a microscopic or nanoscopic sensor needs to be changed multiple times, i.e., in order to build layered structures, for obtaining binding isotherms, and kinetic information, for example, on ion channels, enzymes, and receptors as well as in applications where different loci on an object need to be exposed to different environments or where complex solution environments need to be created for studies of interfacial chemistry between two streaming layers.
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts (2019)

Formation of intrahepatic bile ducts (IHBDs) proceeds in accordance with their microenvironment. Particularly, mesenchymal cells around portal veins regulate the differentiation and ductular morphogenesis of cholangiocytes in the developing liver; however, further studies are needed to fully understand the arrangement of IHBDs into a continuous hierarchical network. This study aims to clarify the interaction between biliary and liver mesenchymal cells during IHBD formation. To identify candidate factors contributing to this cell-cell interaction, mesenchymal cells were isolated from embryonic day 16.5 matrix metalloproteinase 14 (MMP14)-deficient (knockout [KO]) mice livers, in which IHBD formation is retarded, and compared with those of the wild type (WT). WT mesenchymal cells significantly facilitated the formation of luminal structures comprised of hepatoblast-derived cholangiocytes (cholangiocytic cysts), whereas MMP14-KO mesenchymal cells failed to promote cyst formation. Comprehensive analysis revealed that expression of vasoactive intestinal peptide (VIP) was significantly suppressed in MMP14-KO mesenchymal cells. VIP and VIP receptor 1 (VIPR1) were mainly expressed in periportal mesenchymal cells and cholangiocytic progenitors during IHBD development, respectively, <i>in vivo</i>. VIP/VIPR1 signaling significantly encouraged cholangiocytic cyst formation and up-regulated tight junction protein 1, cystic fibrosis transmembrane conductance regulator, and aquaporin 1, <i>in vitro</i>. VIP antagonist significantly suppressed the tight junction assembly and the up-regulation of ion/water transporters during IHBD development <i>in vivo</i>. In a cholestatic injury model of adult mice, exogenous VIP administration promoted the restoration of damaged tight junctions in bile ducts and improved hyperbilirubinemia. <i>Conclusion:</i> VIP is produced by periportal mesenchymal cells during the perinatal stage. It supports bile duct development by establishing tight junctions and up-regulating ion/water transporters in cholangiocytes. VIP contributes to prompt recovery from cholestatic damage through the establishment of tight junctions in the bile ducts.
The Sino-Soviet Rupture and the Vietnam War (1997)

Abstract This chapter examines the aggravation for the conflict between China and the Soviet Union during the early 1960s. After the January 1963 East Germany party congress, the CCP and the Communist Party of the Soviet Union (CPSU) issued a series of polemics. The only point of agreement was that the situation was critical. While the Chinese believed that there was a serious threat against world communist movements, the Russians referred to serious differences on cardinal issues of policy. A major focus of the rival polemics was Yugoslavia.
On Relay Placement for Deterministic Line Networks (2010)

We consider a unicast communication problem where a source transmits information to a destination through a wireless network with the help of k relays positioned on a line. We adopt the linear deterministic model to capture the wireless signal interactions and study the optimal placement of the relays so that the capacity from the source to the destination in the deterministic network is maximized. Analytical results are provided for a number of special cases, and the insights gained are used to provide a heuristic framework for designing large relay networks.
Monodentate Phosphoramidites: A Breakthrough in Rhodium‐Catalysed Asymmetric Hydrogenation of Olefins (2003)

Abstract Monodentate phosphoramidites based on BINOL or substituted BINOL are excellent ligands for the rhodium‐catalysed asymmetric hydrogenation of olefins. Very high enantioselectivities were obtained with MonoPhos ( 7a ) the simplest member of this class, a ligand that is prepared in a single step from BINOL and HMPT. Turnover numbers up to 6000 have been obtained in the hydrogenation of dehydroamino acid derivatives. Enantioselectivities in the hydrogenation of dehydroamino acids are solvent dependent; in non‐protic solvents they range from 95–99%. Itaconic acid and its dimethyl ester could be hydrogenated with 96 and 94% e.e., respectively. Hydrogenation of aromatic enamides gave the corresponding acylated amines in 86–94% e.e. Several analogous phosphoramidite ligands have been prepared. Surprisingly, bidentate ligands gave poorer results, both in terms of rate as well as enantioselectivity. Taddol‐based phosphoramidites led to poor e.e. and slow rates. Methyl substituents at the 3,3′‐position of BINOL led to a sharply reduced rate and a somewhat lower enantioselectivity. Bromo substituents at the 6,6′‐position led to a slightly reduced rate but little effect was seen on enantioselectivity. Use of octahydro‐MonoPhos ( 11 ) gave results that were very similar to those obtained with 7a . The rate of the reaction is dependent on the hydrogen pressure, however, the enantioselectivity is not affected. The rate of the dehydroamino acid hydrogenation also increases if the ligand to rhodium ratio is reduced from 2.2 to 1.5 or even to 1.0; yet, there is no deleterious effect on the enantioselectivity. Catalytic activity ceases with L/Rh=3 when dehydroamino acid derivatives were used as substrate. The reaction shows a positive non‐linear effect, which confirms the presence of Rh‐complexes with more than one ligand. Following the hydrogenation of methyl 2‐acetamidocinnnamate with Rh(nbd) 2 BF 4 / 7a by electrospray mass spectrometry showed the presence of several rhodium species. Notable are the presence of [Rh( 7a )] 3 + and [Rh( 7a )] 4 + . There is at present insufficient evidence to conclude if the active catalytic species carries one or two ligands. In view of the low cost of MonoPhos this invention might well lead to a broader application of asymmetric olefin hydrogenation for the production of enantiopure amino acids and amines.
Alkaline Chemical Stability of Polymerized Ionic Liquids with Various Cations (2015)

The success of long-lasting low-cost (nonplatinum) alkaline fuel cells is dependent on the development of anion exchange membranes (electrolyte separator) with high alkaline chemical stability. In this study, a series of methacrylate-based polymerized ionic liquids (PILs) were synthesized with various covalently attached cations: butylimidazolium, butylmethylimidazolium, trimethylammonium, pentamethylguanidinium, butylpyrrolidinium, and trimethylphosphonium. The alkaline chemical stability of these PILs was examined in tandem with their analogous ionic salts: 1-butyl-3-methylimidizolium chloride, 1-butyl-2,3-dimethylimidazolium chloride, tetramethylammonium chloride, benzyltrimethylammonium chloride, hexamethylguanidinium chloride, 1,1-butylmethylpyrrolidinium chloride, and tetramethylphosphonium chloride. The degradation mechanisms and extent of degradation were quantified using 1H NMR spectroscopy at various pHs (in D2O), and temperature. The PILs with imidazolium and pyrrolidinium cations showed enhanced chemical stability relative to the PILs with ammonium and phosphonium cations. Interestingly, direct correlations were not observed between the PILs and their analogous small molecule ionic salts; significant degradation was observed in imidazolium ionic salts, most notably at high temperature/high pH conditions, while the pyrrolidinium-, ammonium-, and phosphonium-based ionic salts showed no degradation under any of the conditions examined. Additionally, results on the imidazolium ionic salts showed that methyl substitution in the C2 position limited the ring-opening degradation reaction, whereas the PIL with the unsubstituted imidazolium actually showed higher chemical stability relative to its substituted PIL counterpart. Overall, the alkaline chemical stability of the PILs in this study showed no correlation to that of their analogous small molecule ionic salts, suggesting that alkaline chemical stability studies on small molecules may not provide a solid basis for evaluating alkaline stability in polymers, counter to the hypothesis in many previous studies.
PS 05-04 VALIDATION OF THE FREESCAN PULSE TRANSIT TIME-BASED BLOOD PRESSURE MONITOR (2016)

Objective: A novel portable cuffless blood pressure (BP) monitor, FREESCAN, has been developed by Maisense Inc. Blood pressure was calculated by the information including body height, gender and pulse wave velocity (PWV), measured by electrodes and a force sensor on the radial pulse. The accuracy of the BP measuring devices is of prime importance and should be validated before devices are used clinically. Design and Method: This validation study followed the procedure of section 5.2.4.2, same arm sequential method, in ISO 81060–2:2013. This device is intended for use on adults only. Number of subjects, age distribution and BP distribution complied with the ISO recommendations. Two trained observers made simultaneous BP determinations on each participant using a mercury sphygmomanometer with a double stethoscope. Device calibration for each subject is done initially. After waiting for at least 60 seconds, the observers determine the subject's blood pressure by FREESCAN blood pressure monitor. According to the protocol, three valid BP determinations have been taken for each subject. Results: The main validation test was performed in 100 subjects (66 males and 34 females) for a total of 300 measurements. Systolic BP ranged from 86 to 198 mmHg and diastolic BP ranged from 50 to 139 mmHg. After calibration, the average difference and standard deviation of systolic BP are -1.39 and 4.20 mmHg, respectively. The average difference and standard deviation of diastolic BP are 0.32 and 2.52 mmHg, respectively. Conclusions: Our study results revealed that the cuffless BP monitor achieves the criterion of ISO 81060–2:2013. This novel device is suitable for portable and home BP monitoring by patients themselves.
Functionalized Fullerenes in Photodynamic Therapy (2014)

Since the discovery of C60 fullerene in 1985, scientists have been searching for biomedical applications of this most fascinating of molecules. The unique photophysical and photochemical properties of C60 suggested that the molecule would function well as a photosensitizer in photodynamic therapy (PDT). PDT uses the combination of non-toxic dyes and harmless visible light to produce reactive oxygen species that kill unwanted cells. However the extreme insolubility and hydrophobicity of pristine CO60, mandated that the cage be functionalized with chemical groups that provided water solubility and biological targeting ability. It has been found that cationic quaternary ammonium groups provide both these features, and this review covers work on the use of cationic fullerenes to mediate destruction of cancer cells and pathogenic microorganisms in vitro and describes the treatment of tumors and microbial infections in mouse models. The design, synthesis, and use of simple pyrrolidinium salts, more complex decacationic chains, and light-harvesting antennae that can be attached to C60, C70 and C84 cages are covered. In the case of bacterial wound infections mice can be saved from certain death by fullerene-mediated PDT.
How scaling will change processor architecture (2004)

For the past 30 years processors have hidden scaling from the programmer, presenting the same sequential computational interface. Power and wire scaling issues are causing this interface to change, exposing more parallelism. For efficiency, future machines must be distributed and heterogeneous and will add at least a "stream" programming interface.
Multi-Flex Field Trial over 762km of G.652 SSMF Using Programmable Modulation Formats up to 64QAM (2016)

We demonstrate next-generation network upgrade scenarios using flexi-format (PM-QPSK➔PM-64QAM) and flexi-rate (100G300G) transmission over field-deployed fiber (762km). The back-to-back penalties are limited to ~2.6dB, whereas after transmission, available margin in excess of ~7.6dB is reported.
Measurements and Ray Tracing Simulations: Impact of Different Antenna Positions on Meeting Room Coverage at 60 GHz (2020)

We consider the indoor signal propagation at mmWave frequency in an office environment. While channel measurements are widely used to give insights on the propagation phenomena, the use of measurements for the wireless system performance evaluation is limited. In contrary, carefully executed Ray Tracing (RT) simulations represent easier and more flexible option, but careful validation of simulation methodology is needed. The target of this paper is to highlight the use of an in-house built RT tool at 60 GHz, and show the effectiveness of simulations in predicting different characteristics of the channel by validating the simulation results against measurements. The acquired results highlight the impact of type and position of the transmit antenna on the path loss and spatial angular impulse response of the channel in a typical meeting room scenario. In first configuration, the antenna is placed in the middle of the table, while in second configuration the transmit antenna is located in the corner of the meeting room. We have studied the channel characteristics with respect to two Receiver (Rx) antenna orientations i.e., Direct Orientation (DO) and the Best Indirect Orientation (BIO). In first configuration, the observed RMS error between the measured and the simulated Path Loss (PL) is around 2.6 dB and 2.9 dB in case of DO and BIO, respectively. The acquired simulated results also indicate few discrepancies in the measurement results in case of second configuration. Delay spread of first configuration was found smaller compared to the second configuration.
Bayesian Inference of Functional Connectivity and Network Structure From Spikes (2008)

Current multielectrode techniques enable the simultaneous recording of spikes from hundreds of neurons. To study neural plasticity and network structure it is desirable to infer the underlying functional connectivity between the recorded neurons. Functional connectivity is defined by a large number of parameters, which characterize how each neuron influences the other neurons. A Bayesian approach that combines information from the recorded spikes (likelihood) with prior beliefs about functional connectivity (prior) can improve inference of these parameters and reduce overfitting. Recent studies have used likelihood functions based on the statistics of point-processes and a prior that captures the sparseness of neural connections. Here we include a prior that captures the empirical finding that interactions tend to vary smoothly in time. We show that this method can successfully infer connectivity patterns in simulated data and apply the algorithm to spike data recorded from primary motor (M1) and premotor (PMd) cortices of a monkey. Finally, we present a new approach to studying structure in inferred connections based on a Bayesian clustering algorithm. Groups of neurons in M1 and PMd show common patterns of input and output that may correspond to functional assemblies.
Lektion 6: Extruder-Sonderbauarten (2017)

No AccessTechnologie der ExtrusionDec 2017Lektion 6: Extruder-SonderbauartenHelmut Greif, Andreas Limper, Gordon FattmannHelmut Greif, Andreas Limper, Gordon Fattmannhttps://doi.org/10.3139/9783446436947.006SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2017Pages: 63-75Print ISBN: 978-3-446-43693-0eISBN: 978-3-446-43694-7 Copyright & Permissions© 2017 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Laboratory and On-field Data Collected by a Head Impact Monitoring Mouthguard (2019)

Although concussion continues to be a major source of acute and chronic injury in automotive, athletic and military arenas, concussion injury mechanisms and risk functions are ill-defined. This lack of definition has hindered efforts to develop standardized concussion monitoring, safety testing and protective countermeasures. Recent research has provided evidence of the role of repetitive head impact exposure as a predisposing factor for the onset of concussion using developed instrumented helmets and mouthguards.To overcome this knowledge gap, we have developed, tested and deployed a head impact monitoring mouthguard (IMM) system. In this study, we deployed the IMM system to gather high quality estimates of athlete head impacts in situ. And with enough longer-term data collection, potential concussive events or mild traumatic brain injuries (mTBIs) will be gathered and ideally will provide actionable risk-based threshold.
Design of a high temperature signal conditioning ASIC for engine control systems - HIGHTECS (2014)

This paper covers the development and testing of a high temperature electronics platform for integration with sensor elements to provide digital outputs that can be utilized by the FADEC (Full Authority Digital Electronic Control) system or the EHMS (Engine Health Monitoring System) on an aircraft engine. The developed system includes a reference voltage generator, biasing circuit, signal conditioning for multiple types of sensors, an Analogue to Digital converter, and an ARINC 429 transmitter for communication to the FADEC or EHMS. This system was designed and realized on 1 um Silicon-on-Insulator CMOS (Complementary Metal Oxide Semiconductor) technology and has been shown to function up to 250 degrees Celsius with low temperature coefficients for the bandgap voltage and reference current.
Optimization of a phosphine oxide disulfoxide array for multipoint hydrogen bonding to ammonium ions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimization of a phosphine oxide disulfoxide array for multipoint hydrogen bonding to ammonium ionsPaul B. Savage, Steven K. Holmgren, and Samuel H. GellmanCite this: J. Am. Chem. Soc. 1993, 115, 17, 7900–7901Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00070a055https://doi.org/10.1021/ja00070a055research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts