gebhart/patrepeval huggingface dataset:
Synthesis and x-ray Structure of [H3O+.cntdot.18-crown-6][I7-]. A New Infinite Sawhorse Geometry for I7- Crystallized from a Liquid Clathrate Medium (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and x-ray Structure of [H3O+.cntdot.18-crown-6][I7-]. A New Infinite Sawhorse Geometry for I7- Crystallized from a Liquid Clathrate MediumPeter C. Junk, Leonard R. MacGillivray, Michael T. May, Kerry D. Robinson, and Jerry L. AtwoodCite this: Inorg. Chem. 1995, 34, 22, 5395–5396Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ic00126a001https://doi.org/10.1021/ic00126a001research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Octahedral Chiral‐at‐Metal Iridium Catalysts: Versatile Chiral Lewis Acids for Asymmetric Conjugate Additions. (2015)

Abstract Chiral iridium(III) complexes are applied as versatile catalysts in numerous asymmetric transformations of α,β‐unsaturated carbonyl compounds, namely Friedel‐Crafts alkylations, Michael additions with CH‐acidic compounds and cycloadditions with nitrones and alkenes.
System identification of human joint dynamics. (1990)

The dynamics of joint mechanics are a fundamental characteristic of the motor system. They determine the displacements evoked by perturbing forces during postural control and the forces that must be generated to perform a voluntary movement. This article reviews experimental studies of these dynamics, with an emphasis on the behavior of single joints in alert humans. Technical aspects of the experimental and analytic methods that have been used are summarized first. Major results obtained with the different methods are then reviewed, compared, and contrasted. The interpretation of these results in terms of the underlying physiological mechanisms is then considered, with an emphasis on the relative contributions of passive properties of tissue, the mechanical behavior of muscle, and stretch reflexes. Finally, important unanswered questions regarding the dynamics of joint mechanics are reviewed.
Nucleotide Distribution and Functional Orientation in the Deoxyribonucleic Acid of Phage φ80 (1969)

The distribution of nucleotides in the deoxyribonucleic acid (DNA) of phi80 was determined by density analysis of molecular fragments of known length and origin. One half of the molecule includes a long, fairly homogeneous segment that contains 55% guanine plus cytosine (GC). DNA in the other half contains about 50% GC, except for a short stretch near the molecular end where the GC content is higher. Transcription of phi80 DNA was studied by ribonucleic acid-DNA hybridization tests with isolated molecular halves. At times early in the growth cycle, messenger is synthesized at a constant, relatively low rate and originates almost exclusively from DNA in the lower-GC half. At later times, messenger represents both halves and is synthesized at a greatly increased rate. The DNA of phi80 is closely analogous, physically and functionally, to lambda DNA. The similarity is most striking in the high-GC half, which is defined here as "left" since its molecular end contains a cohesive site homologous to that at lambda's left end. The left halves of the DNA of the two phages contain primarily late-functioning genes, and possess similar nucleotide distributions and some similar base sequences. The right halves of the two DNA molecules are less similar. Both contain the early genes, but they differ considerably in GC content (45% in lambda, 51% in phi80) and do not strongly cross-react in hybridization tests. The DNA of phi80 lacks the central 37%-GC segment found in lambda.
Robust 5 kA, 1 kV Solid-State DC Circuit Breaker for Next Generation Marine Power Systems (2021)

Recent developments in maritime vessels have seen a continuous drive towards All-electric Ships (AES). DC distribution enables highly efficient integration of primary storage, energy storage and loads in confined spaces. However, ensuring reliable fault protection for such systems is paramount to meeting the stringent reliability and availability requirements of marine power systems. In this regard, solid-state circuit breakers (SSCB) demonstrated to provide fast and reliable fault interruption using well-proven semiconductor technologies. In previous work, RB-IGCTs have been demonstrated to be a promising candidate for SSCBs, providing high efficiency and robustness. In this paper, we present a comprehensive investigation of a complete SSCB design based on RB-IGCT technology for high power, future-ready electric ships. Moreover, experimentally validated robustness of the SSCB technology is also presented. This experimentally validated DC SSCB technology is a strong contender to become backbone of DC power systems in next generation marine and electric ship applications.
Intrusive memories of hallucinations and delusions in traumatized intensive care patients: An interview study (2014)

We found that patients in this in-depth study were more traumatized by frightening hallucinations/delusions than real events, suggesting they may have post-psychosis PTSD, rather than classic PTSD. Interventions are needed to diagnose and treat intensive care hallucinations/delusions, or minimize effects, to prevent PTSD.
High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform (2023)

Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes. The progressive shortening of steady-state telomere length in normal human somatic cells is a promising biomarker for age-associated diseases. However, there remain substantial challenges in quantifying telomere length due to the lack of high-throughput method with nucleotide resolution for individual telomere. Here, we describe a workflow to capture telomeres using newly designed telobaits in human culture cell lines as well as clinical patient samples and measure their length accurately at nucleotide resolution using single-molecule real-time (SMRT) sequencing. Our results also reveal the extreme heterogeneity of telomeric variant sequences (TVSs) that are dispersed throughout the telomere repeat region. The presence of TVSs disrupts the continuity of the canonical (5'-TTAGGG-3')n telomere repeats, which affects the binding of shelterin complexes at the chromosomal ends and telomere protection. These findings may have profound implications in human aging and diseases.
Lung Function and Breathing Pattern in Subjects Developing High Altitude Pulmonary Edema (2012)

The results comprehensively represent the pattern of physiologic alterations that precede overt HAPE. The changes in lung function are consistent with reduced lung compliance and impaired gas exchange. Pronounced nocturnal hypoxemia, ventilatory control instability and sympathetic stimulation are further signs of subsequent overt HAPE.
Comparison of shear-induced crystallization behavior of PB-1 samples with different molecular weight distribution (2005)

Shear-induced crystallization behavior of three grades of PB-1 having different molecular weights and breadths of molecular weight distribution was investigated by means of rotational rheometry covering a shear rate range of 0.0001 up to 0.3 s-1 and temperatures between 99 °C and 107 °C. The up-shoot in viscosity after a certain time is used to define an onset time ton for both quasiquiescent and shear-induced crystallization. The plot of ton versus the shear rate can be converted into a temperature-invariant curve by dividing the y axis by quiescent onset time ton,q and multiplying the x axis by the square root of ton,q. The shape and location of the T-invariant curves for the three PB-1 samples are compared with respect to their molecular parameters. An additional normalization step by multiplying the abscissa by the square root of the characteristic retardation time of the melt yields a dimensionless representation of the T-invariant curve. Furthermore, by this procedure the three curves are shifted into one region, where they have the same threshold value, indicating the onset of shear-induced crystallization. A connection of this T-invariant curve to the morphology of the crystallites formed are addressed.
Highly Active and Removable Ruthenium Catalysts for Transition‐Metal‐Catalyzed Living Radical Polymerization: Design of Ligands and Cocatalysts (2008)

The systematic search and design of phosphine ligands (PR(3)) and amine cocatalysts resulted in obtaining pentamethyl-cyclopentadienyl (Cp*) ruthenium(II) phosphine complexes [RuCp*Cl(PR(3))(2)], which are highly active and removable catalysts, for transition-metal-catalyzed living radical polymerization of methyl methacrylate (MMA). The catalysts are conveniently prepared in situ from a tetrameric precursor [RuCp*(mu(3)-Cl)](4) and a selected phosphine (PR(3)). The combination of the meta-tolyl phosphine [P(m-Tol)(3)] ligand and a primary diamine cocatalyst [NH(2)(CH(2))(6)NH(2)] provides a highly active catalytic system with precision control of the molecular weight of the polymer. The high activity enables a low catalyst dose and a high turn-over frequency without deteriorating the controllability. A hydrophilic amine cocatalyst (amino alcohol) in place of the diamine, further forms an active and removable catalyst; simple treatment with acidic water gave colorless polymers visually free from metal residues (>97 % removal; <64 ppm).
Reduced lateral leakage losses of TM-like modes in silicon-on-insulator ridge waveguides (2008)

We numerically investigate the lateral leakage losses of TM-like modes in silicon-on-insulator ridge waveguides and propose a novel ridge waveguide structure with low leakage losses over a wide wavelength range.
Toward Long-Distance Mechanical Communication: Studies on a Ternary Complex Interconnected by a Bridging Rotary Module (2008)

A heterotropic ternary complex was obtained from a photochromic dithienylethene derivative bearing pyridyl groups (1), a chiral tetrasubstituted ferrocene as a scissoring component bearing two pyridyl and free-base porphyrin groups (3*), and a biaryl derivative as an intermediately bridging component bearing four zinc porphyrin handles (2). The three components are connected together via bidentate coordination bonds and mechanically interconnected. Exposure of the ternary complex to UV or visible light allowed for the isomerization of 1. This configurational change gave rise to an angular motion of 2, resulting in a scissoring motion of 3*. In the absence of 2, the isomerization of 1 does not lead to any defined motions of 3*. Thus, the heterotropic ternary complex may be regarded as a prototype of "molecular reacher" for remote manipulation of molecular events.
Modulation of oculomotor control & adaptation with cerebellar TMS: effects on saccades. (2017)

The cerebellum plays a significant role in oculomotor control. Previous fMRI, repetitive TMS and lesion studies indicate its involvement in the adaptation of saccadic eye movements in humans. Building on this work, we applied continuous theta-burst (cTBS) TMS to the oculomotor vermis (OMV) of the posterior cerebellum to investigate its specific role in the execution of reactive pro-saccades and their adaptation to a double-step stimulus. 16 healthy controls completed 2 study visits where reactive pro-saccades and their adaptation to a gain reducing double-step stimulus were measured binocularly via infrared oculography at 250Hz. Active or sham cTBS (3-50Hz pulses at 200ms intervals for 40 seconds) was applied to the OMV using a 2x75mm butterfly coil at 80% of the individual's active motor threshold before completing the saccadic tasks at each visit. Stimulation sites were localized using the BrainSight® neuro-navigation system and anatomical landmarks. Compared to sham, active cTBS significantly reduced the adaptation of saccadic gain by 46.8% (p< 0.0001). The adaptive reduction of peak velocity after active cTBS was 79.4% less than sham (p< 0.0001), while the reduction of saccade duration was 55.2% less (p=0.009). Baseline pro-saccade gain was reduced by active (0.97±0.01) vs. sham (0.99±0.009) stimulation (p = 0.034). Baseline latency was not different between active (185ms) and sham (181ms) conditions (p = 0.34) and was not affected by stimulation type after adaptation (active = +1.2ms, sham = +2.5ms, p>0.50). These results demonstrate the central role of the OMV in the feed-forward control and feed-back driven adaptation of reactive pro-saccades, consistent with previous work. In addition, the results are the first to clearly establish the robust inhibitory effects of cTBS on oculomotor control and adaptation when applied to the OMV of the posterior cerebellum. Meeting abstract presented at VSS 2017
FlashBlox: achieving both performance isolation and uniform lifetime for virtualized SSDs (2017)

A longstanding goal of SSD virtualization has been to provide performance isolation between multiple tenants sharing the device. Virtualizing SSDs, however, has traditionally been a challenge because of the fundamental tussle between resource isolation and the lifetime of the device - existing SSDs aim to uniformly age all the regions of flash and this hurts isolation. We propose utilizing flash parallelism to improve isolation between virtual SSDs by running them on dedicated channels and dies. Furthermore, we offer a complete solution by also managing the wear. We propose allowing the wear of different channels and dies to diverge at fine time granularities in favor of isolation and adjusting that imbalance at a coarse time granularity in a principled manner. Our experiments show that the new SSD wears uniformly while the 99th percentile latencies of storage operations in a variety of multi-tenant settings are reduced by up to 3.1x compared to software isolated virtual SSDs.
ChemInform Abstract: Synthesis and Application of Alkenylstannanes Derived from Base‐Sensitive Cyclopropenes. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 3800: Antiproliferative effect of fingolimod (FTY720) in human prostate cancer cells: Insights to estrogen metabolism in situ (2014)

Abstract Sphingokinase-1/sphingosine-1-phosphate pathway contributes significantly to progression of different types of cancer which has been recently reported to influence estrogen level in breast cancer cells. Current evidence suggests that estrogen (E2) and its metabolites, especially catechol metabolites, are playing a key role in the proliferation and carcinogenesis of the prostate glands. FTY720 is Sphingokinase-1inhibitorwhich possess anticancer properties in various tumor cell types. The aim of this study is to investigate the chemotherapeutic effect of FTYY720 against prostate cancer cells with emphasis on estrogenic microenvironment in-situ. The IC50 of FTY720 in DU145 cell line was4.2±1.4µg/ml. The concentration of estrogen and its metabolites were assayed in the media over DU145 cells using liquid chromatography tandem mass (LC/MS) technique. FTY720 treatment resulted in a dramatic decrease in estradiol (E2) and estrone (E1) levels compared to control untreated cells (2652.76±115.62 vs. 725.69±1.28 and 283.36±4.18vs. 150.32±8.96ng/g, respectively); however, it had no significant effect on the concentration of Estriol(E3). In terms of catechol estrogens, 4-hydroxyEstradiol (4-OHE2) and 2-hydroxy Estradiol (2-OHE2) formation was significantly decreased after treatment withFTY720 compared to control cells (25.42±2.40 vs. 7.45±0.82 and 485.93±3.10 vs. 477.42±4.24 ng/g), respectively. FTY720 had no significant effect on formation of 16α-hydroxyEstrone (16 α-OHE1). On the other hand, treatment with FTY720 significantly increased the concentration of 2-methoxyestrone (2-MOHE1) and 2-methoxyestradiol (2-MOHE2) compared to control cells (5.45±0.12 vs. 29.94±2.97 and165.62±5.67 vs. 269.97±15.85), respectively..The expression of catechol estrogen synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) was significantly decreased within prostate cancer cells after treatment with FTY720 compared to untreated counterpart. On the other hand, the expression level of catechol estrogen degrading enzyme (COMT) was significantly decreased. Cell cycle analysis of DU145 cells showed arrest at G1 phase with significant decrease in the G2-M population due to treatment with FTY720. In conclusion, FTY720 induced anti proliferative effect in prostate cancer cells might be attributed partly to its influence on estrogen metabolism in-situ. Citation Format: Rasha M. Allam, Hisham A. Mosli, Amany E. Khalifa, Salwa M. Nofal, Ola A. Sharaf, Ashraf B. Abdel-Naim, Ahmed M. Al-Abd. Antiproliferative effect of fingolimod (FTY720) in human prostate cancer cells: Insights to estrogen metabolism in situ. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3800. doi:10.1158/1538-7445.AM2014-3800
Secondary and Tertiary Gas Injection Experiments in Heterogeneous Wettability Micromodels (1998)

Abstract Gas injection processes occupy an important place among improved oil recovery methods. In such processes three phases (water, oil, gas) coexist within the porous matrix. It has been already proved that the wettability characteristics of the solid surface and the spreading characteristics of the fluid system hold the key roles when three phases flow simultaneously in a porous medium. The objective of the present work is to analyse the effect of the wettability heterogeneities on the sweep efficiency of a gas injection by looking at the microscopic displacement mechanisms in three-phase flow when heterogeneities are involved. To this end an experimental investigation is performed in transparent glass micromodels of heterogeneous wettability. Secondary and tertiary gas injection experiments are conducted for different heterogeneity patterns. Oil-wet patches in a water-wet matrix are obtained by selective silane grafting on the glass surface. Displacement sequences are video-recorded and fluid saturations are determined by image analysis. Both experiments at secondary and tertiary conditions show that the size and distribution of wettability heterogeneities strongly affect the microscopic and macroscopic behavior during gas injection processes.
New Convergent Synthesis of Carbocyclic Nucleoside Analogues (2003)

Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSal-pronucleotide and the corresponding nucleotide will be presented for one example.
Voxar puzzle motion: an innovative ar application proposed using design techniques (2016)

This work presents and discusses the creation of an application to the Voxar Puzzle, an AR platform that has been built in order to promote children's education in a fun and lively way. The application was conceived using a well-structured methodology named Create Innovation Pack that is based on the design thinking theory. This method aims at helping to exploit the potential of a technology to deliver value to the user of a field, which in this case is children education. It applies the use of interdisciplinary teams with complementary skills, in which the technology developers are key members. The goal is to conceive solutions that are both innovative and with high impact potential. Thus, the application presented in this work was generated by teachers, educational researchers, a designer, AR researchers and an entrepreneur whose solutions proposed aimed to meet three criteria: desirability, viability and feasibility. The application conceived, the Voxar Puzzle Motion, therefore, combines knowledge from different areas: education, design, computer science and entrepreneurship. It is aimed at children aged 3 to 8 years old and intends to foster their motor skills as well as their logic-mathematical and logic reasoning cognitive abilities.
Contact analysis studies of an ESCAP resist with scCO 2 compatible additives (2009)

Rapid technological advances have presented several environmental issues and call for the use of environmentally friendly processes. Supercritical carbon dioxide (scCO<sub>2</sub>) is a widely used solvent that can enhance processing performance in photolithography, especially in the development step. Supercritical CO<sub>2</sub> is a good solvent for many nonpolar molecules with low molecular weights. However, it is generally a very poor solvent for high molecular-weight photoresists. Recently researchers have reported the ability to develop conventional polymeric resists in scCO<sub>2</sub> using tailored soluble additives. The mechanism of dissolution of a polymer photoresist in scCO<sub>2</sub> in the presence of these additives is clearly at a very early stage of understanding. To understand this mechanism in more detail, we synthesized a series of scCO<sub>2</sub> compatible quaternary ammonium salts (QAS) and used them as additives in the dry development of model and commercially available photoresists. In this paper, we describe the various interactions that the QAS additive has with the different functional groups on the polymer resist to assist its dissolution in scCO<sub>2</sub>. Using contact analysis plots we report the dominant interactions between the additive and the resist material. We report the results with two salts (QAS-I and QAS-II) to show the structure-property relation of these amphiphilic additives with an ESCAP resist. Finally, we report the lithographic evaluation of a commercial EUV resist using an appropriate scCO<sub>2</sub> compatible QAS after development in scCO<sub>2</sub>.