gebhart/patrepeval huggingface dataset:
CD4 T Lymphocyte Proliferative Responses to Hepatitis C Virus (HCV) Antigens in Patients Coinfected with HCV and Human Immunodeficiency Virus Who Responded to Anti‐HCV Treatment (2002)

CD4 T lymphocyte proliferative responses to hepatitis C virus (HCV) antigens were evaluated before and during an anti-HCV regimen (interferon-alpha2a and ribavirin) in 36 patients coinfected with HCV and human immunodeficiency virus (HIV), to determine whether immune responses against HCV antigens are present in such patients, whether these responses are modified by anti-HCV treatment, and whether they are correlated with treatment efficacy. The CD4 responses against HCV antigens (primarily core antigens) detected at study entry in one-half of the patients did not correlate with anti-HCV treatment efficacy. Of 36 patients, 8 had patterns of persistent immune response to infection by genotypes 3 or 4 that were significantly correlated with sustained virologic response. Persistent immunologic reactivity and sustained virologic response coexisted only in patients infected with genotype 3. These findings suggest that HCV genotype may influence specific immune response, which, in turn, is implicated in virologic control.
An overview of pervasive computing (2001)

The importance of pervasive computing is rapidly increasing with the current trend toward universal presence of mobile computing, computer networks, and wireless communications in everyday life. In the last decade, there has been a dramatic increase in the use of companion devices and embedded computing devices. For example, wirelessly connected organizers and smartphones are becoming popular, and digital computing in some form is now an integral part of numerous everyday appliances. This has led to a change in the way we perceive computing and computers. Computers are no longer standalone special-purpose machines to be used by experts; rather, they are ubiquitously present in a networked environment to serve myriad needs of everyday life. The change in our perception of computing and computing devices, and their ever increasing presence in our everyday life is the subject of the new field known as pervasive computing.
Acute Effects of Heated Tobacco Product (IQOS) Aerosol Inhalation on Lung Tissue Damage and Inflammatory Changes in the Lungs (2020)

Exposure of mice to IQOS, one of the candidate modified-risk tobacco products, induces inflammatory immune-cell accumulation in the lungs and augments the levels of proinflammatory cytokines and chemokines in the BAL fluid. Such an exacerbated pulmonary proinflammatory microenvironment is associated with lung epithelial-cell damage in IQOS-exposed mice, suggesting a potential association with the impairment of lung function.
An international, multi-institution survey on performing EUS-FNA and fine needle biopsy (2020)

This is the first worldwide survey of EUS-FNA and FNB practice patterns. The results showed wide variations in practice patterns. Randomized studies are urgently needed to establish the best approach for optimizing the FNA/FNB procedures.
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression (1986)

DMSO (dimethylsulfoxide), a potent inducer of granulocytic differentiation in HL60 cells, causes a rapid decrease of cytoplasmic steady state c-myc RNA. This decrease is regulated mainly at the level of transcript elongation. Elongation is blocked within the untranslated c-myc leader. Twelve hours after transcriptional shut off of c-myc, DNAase I hypersensitive site II was still detectable, indicating that closing of this site upstream of the gene does not correlate with reduction in the steady state level of c-myc RNA.
AdaEmb-Encoder: Adaptive Embedding Spatial Encoder-Based Deduplication for Backing Up Classifier Training Data (2020)

The advent of the AI era has made it increasingly important to have an efficient backup system to protect training data from loss. Furthermore, a backup of the training data makes it possible to update or retrain the learned model as more data are collected. However, a huge backup overhead will result if a complete copy of all daily collected training data is always made to backup storage, especially because the data typically contain highly redundant information that makes no contribution to model learning. Deduplication is a common technique in modern backup systems to reduce data redundancy. However, existing deduplication methods are invalid for training data. Hence, this paper proposes a novel deduplication strategy for the training data used for learning in a deep neural network classifier. Experimental results showed that the proposed deduplication strategy achieved 93% backup storage space reduction with only 1.3% loss of classification accuracy.
Experimental Determination of the Absorption Cross-Section and Molar Extinction Coefficient of Colloidal CdSe Nanoplatelets (2015)

There has been a strong interest in solution-processed two-dimensional nanomaterials because of their great potential in optoelectronics. Here, the absorption cross-section and molar extinction coefficient of four and five monolayer thick colloidal CdSe nanoplatelets (NPLs) having various lateral sizes are reported. The absorption cross-section of these NPLs and their corresponding molar extinction coefficients are found to strongly depend on the lateral area. An excellent agreement is observed between the experimental results and the calculated values based on the small-particle light absorption model. With these optical properties, NPLs hold great promise for optoelectronic applications. © 2015 American Chemical Society.
EPCT-07. ID1 IS A KEY TRANSCRIPTIONAL REGULATOR OF DIPG INVASION AND IS TARGETABLE WITH CANNABIDIOL (2021)

Abstract Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors with no effective therapies beyond radiation. The highly invasive nature of DIPG is key to its aggressive phenotype, but the factors and mechanisms contributing to this aggressive invasion are unknown. Inhibitor of DNA binding (ID) proteins, key regulators of lineage commitment during embryogenesis, are implicated in tumorigenesis in multiple human solid tumors. Prior work showed that recurrent H3F3A and ACVR1 mutations increase ID1 expression in cultured astrocytes. However, the impact and targetability of ID1 have not been explored in human DIPG. Exome and transcriptome sequencing analyses of multi-focal DIPG tumors and normal brain tissue from autopsy (n=52) revealed that ID1 expression is significantly elevated in DIPG samples. Higher ID1 expression correlates with reduced survival in DIPG patients and increased regional invasion in multi-focal autopsy samples. Analyses of developing mouse brain RNA/ChIP-Seq data revealed high ID1 expression and H3K27ac promoter binding in prenatal hindbrain compared to all other prenatal and postnatal brain regions. ChIP-qPCR for H3K27ac and H3K27me3 revealed that ID1 gene regulatory regions are epigenetically poised for upregulation in DIPG tissues compared to normal brain, regardless of H3/ACVR1 mutational status. These data support that the developing pons is regionally poised for ID1 activation. Genetic (shRNA) ID1 knockdown of primary human H3.3K27M-DIPG cells (DIPG007) resulted in significantly reduced invasion/migration and significantly improved survival of K27M-DIPG mice. Knockdown of ID1 in DIPG cells also resulted in down-regulation of the WNK1-NKCC1 pathway, which regulates tumor cell electrolyte homeostasis and migration. Finally, treatment of DIPG007 cells with cannabidiol (CBD) reduced ID1 levels, viability of DIPG cells and significantly improved survival of K27M-DIPG mice. In summary, our findings indicate that multifactorial (genetic and regional) epigenetic upregulation of ID1 drives DIPG invasiveness; and that targeting ID1 with CBD could potentially be an effective therapy for DIPG.
ChemInform Abstract: Synthesis of Side Chain Modified Apicidin Derivatives: Potent Mechanism‐Based Histone Deacetylase Inhibitors (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrochemical Stability of LiFePO4 Synthesized via Hydrothermal Method (2010)

Abstract not Available.
High Circulatory Titer of Platelet-Associated Autoantibodies in Childhood Onset Schizophrenia and Its Diagnostic Implications (2013)

High titers of PAA in children with schizophrenia as compared with nonpsychotic controls may indicate an active autoimmune process in the early onset of schizophrenia. The PAA level may therefore provide a supportive diagnostic biomarker for childhood schizophrenia.
Elucidation of Rate Variations for a Diels−Alder Reaction in Ionic Liquids from QM/MM Simulations (2006)

The impact of acidic and basic ionic liquid 1-ethyl-3-methylimidazolium chloride (EMIC) melts upon cyclopentadiene and methyl acrylate Diels-Alder reaction rates has been investigated using QM/MM calculations. The ability of the ionic liquid to act as a hydrogen bond donor (cation effect), moderated by its hydrogen bond accepting ability (anion effect), has been proposed previously to explain observed endo/exo ratios. However, the molecular factors that endow ionic liquids with their rate enhancing potential remain unknown. New OPLS-AA force field parameters in conjunction with potentials of mean force (PMF) derived from free energy perturbation calculations in Monte Carlo simulations (MC/FEP) are used to compute activation energies. QM/MM simulations using a periodic box of ions reproduce relative rate enhancements for the EMIC melts compared to water and 1-chlorobutane that reproduce kinetic experiments. Solute-solvent interactions in acidic and basic ionic liquid melts have been analyzed at key stationary points along the reaction coordinate. The reaction rate was found to be greater in the acidic rather than the basic melt due to less-dominant ion-pairing in the acidic melt, enabling the EMI cation to better coordinate to the dienophile at the transition state. The simulations suggest that the hydrogen on C2 of the EMI cation does not contribute to stabilization of the transition state, as previously believed, and the interactions with the more sterically exposed hydrogens on C4 and C5 play a larger role. In addition, the relative stabilization of the transition state through electrostatic interactions with the EMI cation in the acidic melt is also greater than that afforded by the weaker Lewis-acid effect provided by hydrogen bonding with water molecules in aqueous solution.
In-vivo Proton Chemical Shift Imaging at 9.4 T: initial results (2012)

Purpose/Introduction: Despite of the known difficulties (longer T1 and shorter T2 relaxation times, higher SAR and stronger B0 and B1 inhomogeneities), the feasibility of in-vivo 1H MRS at a field strength of 9.4 T has been recently demonstrated in [1]. Since the main advantage of CSI over SVS is providing the additional information about the spatial distribution of metabolites, the aim of this study was to examine the feasibility of CSI in the human brain at a field strength of 9.4 T. Subjects and Methods: In-vivo measurements (3 healthy volunteers) were performed on a whole body 9.4 T MR scanner (Siemens, Erlangen, Germany). CSI data were collected with a custom built 8 channel transmit coil combined with a 24 channel receiving helmet. Spectra were acquired with a modified STEAM sequence (TR=2000 ms, TE=20 ms, TM=11 ms, spectral bandwidth: 4000 Hz, voxel size: 10 mm3 isotropic). The main modification of the pulse sequence consisted in replacing the 90° h-sinc RF pulses with 90° hermite pulses, which allowed keeping the reference voltage below the hardware limitations and minimized the RF power deposition. Raw spectra were quantified with LCModel, version 6.2-2B [2] using a basis set (17 metabolites) simulated in VeSPA software (http://scion.duhs.duke.edu/vespa/). Results: It can be seen that all the spectra are decent in terms of SNR and spectral resolution (Fig. 1). Especially in two regions; between ~2.4 and ~2.6 and ~1.9 and ~2.3 ppm: is the overlap between the resonances of Gln, Glu, NAA and NAAG reduced. Quantification with LCModel software (Fig. 2) confirmed those observations. Peaks of NAA, NAAG and Glu were assigned with Cramer-Rao lower bounds (CRLB) below 13. Moreover, 13 metabolites of the 17 included in the basis set were quantified with CLRB below 20. Comparable results have been obtained for the other volunteers. Discussion/Conclusion: It has been demonstrated that 1H MRSI at a field strength of 9.4 T is feasible. All acquired spectra demonstrated good agreement in terms of spectral quality with the results published previously [1, 3]. In conclusion, the enhanced sensitivity in the detection of metabolite resonances with CSI at ultra-high fields combined with the additional information about spatial distribution of the metabolites can provide new insights to the assessment of various pathologies.
Characterization of sintered Cu nanopaste for micro-bumping with Injection Molded Solder technology (2020)

Abstract We have previously developed a novel plating-free bumping process using Cu nanopaste and Injection Molded Solder (IMS) technology. In the present study, we investigated the further detail about the microstructural and mechanical properties of sintered Cu nanoparticles formed into a pillar shape. By analyzing cross-sections of Cu nanoparticle pillars sintered in various conditions, we clarified how the sintering conditions affect the microstructural features, including the size and numbers of Cu grains and voids inside sintered Cu nanoparticles. In addition, we conducted the shear testing for the obtained Cu pillars to evaluate relationships between the mechanical strength and the microstructural features. We found that the results of the shear testing were consistent with the microstructural features of the sintered Cu nanoparticles. Finally, we injected molten solder onto the Cu nanoparticle pillars to evaluate the overall feasibility of the developed process. It was confirmed that the molten solder injected by IMS process has good wettability against the sintered Cu nanoparticles, which resulted in the successful bump formation without solder missing. In addition, The IMC layer between the sintered Cu nanoparticles and injected solder was formed well. These results proved the quality of microbumps fabricated by the novel bumping process using Cu nanopaste and IMS.
Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation (2019)

A correction to this paper has been published and can be accessed via a link at the top of the paper.
Anion exchange perovskite quantum-dots for highly efficient light-emitting-devices (Conference Presentation) (2019)

Here, we demonstrate anion-exchange red perovskite QDs CsPb(Br/I)3 from pristine CsPbBr3 using ammonium-iodine salts, long alkyl-based oleylammonium iodide (OAM-I) and aryl-based aniline hydoroiodide (An-HI), for use in highly efficient light-emitting devices (LEDs). The anion-exchange CsPb(Br/I)3 films exhibit a strong red-shift in their of photoluminescence (PL) spectrum from the green emission at 508 nm in the case of the pristine QDs to one in the deep-red region at 649 nm owing to the replacement of Br– anions by I–¬ anions in the perovskite QDs. LEDs formed using the anion-exchange CsPb(Br/I)3 based on OAM-I show an remarkable high EQE of more than 20% as well as high color purity, with the Commission Internationale de l'Eclairage (CIE) at (0.72, 0.28), which completely cover BT.2020 color gamut. Similarly, the LEDs formed using the QDs based on An-HI show a peak EQE of 14.1% and CIE coordinates of (0.71, 0.28). Further, they exhibit longer operational stability as compared to that of LEDs formed using the OAM-I-based CsPb(Br/I)3.
Dynamic Re‐organization of Individual Adhesion Nanoclusters in Living Cells by Ligand‐Patterned Surfaces (2009)

Ligand-patterned surfaces alter the spatio-temporal organization of specific receptors on the cell membrane. Chemically confined surfaces are fabricated using microcontact patterning. The dynamic re-organization of the integrin LFA-1 in living cells is monitored at the single-molecule level using total internal reflection fluorescence. The image on the left shows individual LFA-1 nanoclusters on a single cell being recruited to ligand-rich areas of the pattern.
Data retention extraction methodology for perpendicular STT-MRAM (2016)

While perpendicular STT-MRAM are seen as a promising next-generation memory, retention becomes critical and must be characterized precisely. Four extraction methods are explained taking special emphasize on accuracy and precision. They are then applied from single cell to kb-array, from 50 to 250 nm diameter cells and up to 235°C in order to show the limitations and advantages of each method.
Pressure dependence of the structure and properties of liquid n-butane (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPressure dependence of the structure and properties of liquid n-butaneWilliam L. JorgensenCite this: J. Am. Chem. Soc. 1981, 103, 16, 4721–4726Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/ja00406a010https://doi.org/10.1021/ja00406a010research-articleACS PublicationsRequest reuse permissionsArticle Views242Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multicenter Investigation of the Micro-Organisms Involved in Penile Prosthesis Infection: An Analysis of the Efficacy of the AUA and EAU Guidelines for Penile Prosthesis Prophylaxis (2017)

This study documents a high incidence of anaerobic, Candida, and methicillin-resistant S aureus infections. In addition, approximately one third of infected penile prosthesis cases had negative cultures. Micro-organisms identified in this study were not covered by the AUA and EAU antibiotic guidelines in at least 14% to 38% of cases. These findings suggest broadening antibiotic prophylaxis guidelines and creating a management algorithm for IPP infections might lower infection rates and improve salvage success. Gross MS, Phillips EA, Carrasquillo RJ, et al. Multicenter Investigation of the Micro-Organisms Involved in Penile Prosthesis Infection: An Analysis of the Efficacy of the AUA and EAU Guidelines for Penile Prosthesis Prophylaxis. J Sex Med 2017;14:455-463.
Highly Selective Hydrogenation of R-(+)-Limonene to (+)-p-1-Menthene in Batch and Continuous Flow Reactors (2017)

In our study, heterogeneous catalysts based on different active metal nanoparticles (Pt, Pd, and Ru) and supports (carbon, silica, and alumina) were systematically tested in hydrogenation of limonene under mild reaction conditions (room temperature, 3 bar H2). The heterogeneous catalyst Pt/C was found highly active and selective for the reduction of limonene into the partial hydrogenation product (+)-p-1-menthene. Pt/C and Pt/Al2O3 are the most active systems among the series of commercially available catalysts that have been investigated. The catalytic activity and stability of Pt/C remained high throughout the recycling tests under batch conditions and thus allowed for the implementation of this catalytic system into continuous flow operations. The selective hydrogenation of the terminal over the internal C═C bond of limonene was rationalized by detailed kinetic studies which revealed an 8-fold difference in reaction rate between the two reactions.
Abstract B14: Pinpointing the origins of pediatric brain tumors using single-cell transcriptomic analysis (2020)

Abstract Childhood tumors of the central nervous system are deadly diseases, and for many tumor types outcome has not improved over the last three decades. Current evidence supports a model in which genetic alterations drive changes in neurodevelopmental gene expression programs, leading to oncogenesis postnatally. We hypothesize that there are specific cellular states during normal brain development that are vulnerable targets for oncogenic mutations. However, comprehensive developmental data for many brain regions relevant to pediatric brain tumors (PBT) are lacking. Here, we leverage single-cell RNA-sequencing to generate a reference transcriptome atlas of the developing brain in two regions where PBT commonly arise, the forebrain and the pons. We profile &amp;gt;65,000 cells from healthy embryonic and neonatal mouse and human specimens, and characterize cellular diversity, dynamics related to differentiation, and transcription factor regulatory activity. We use a novel strategy to project bulk RNA-seq profiles for a cohort of 200 PBT onto these cell types. We show that this projection stratifies tumors by type, and for several PBT subtypes, we identify their closest transcriptional match among the cell populations of the normal developing brain. WNT-subtype medulloblastoma matches the lower rhombic-lip derived mossy fiber neuron lineage. In embryonal tumors with multilayered rosettes, we identify prenatal neurogenic radial glial cells as candidate cells of origin, while Group 2a/b atypical teratoid/rhabdoid tumors originate outside the neuro-ectoderm. Finally, single-cell profiling of patient tumor samples shows that these tumors mimic the transcriptional programs of their corresponding normal lineages and contain a mixture of cells with varying degrees of differentiation. We identify impaired differentiation of specific neural progenitors as a common oncogenic mechanism underlying PBT, and further demonstrate that this differentiation blockade may be reversible. Our findings thus provide a rational framework to guide future modeling and therapeutics. More broadly, we assemble a high-resolution developmental dataset, a valuable resource for the study of neuroscience and many brain pathologies. Citation Format: Selin Jessa, Alexis Blanchet-Cohen, Brian Krug, Maria C. Vladoiu, Marie Coutelier, Damien Faury, Brice Poreau, Nicolas De Jay, W. Todd Farmer, Yixing Hu, Steven Hébert, Jean Monlong, Keith K. Murai, Melissa McConechy, Guillaume Bourque, Jiannis Ragoussis, Livia Garzia, Michael D. Taylor, Nada Jabado, Claudia L. Kleinman. Pinpointing the origins of pediatric brain tumors using single-cell transcriptomic analysis [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr B14.