gebhart/patrepeval huggingface dataset:
Crystal structure analyses of Rh2(bridge)4(BPh4)2.CH3CN and Rh2(TM4-bridge)4(PF6)2.2CH3CN. Further electronic spectral studies of binuclear rhodium(I) isocyanide complexes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structure analyses of Rh2(bridge)4(BPh4)2.CH3CN and Rh2(TM4-bridge)4(PF6)2.2CH3CN. Further electronic spectral studies of binuclear rhodium(I) isocyanide complexesKent R. Mann, John A. Thich, Robert A. Bell, Catherine L. Coyle, and Harry B. GrayCite this: Inorg. Chem. 1980, 19, 8, 2462–2468Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ic50210a054https://doi.org/10.1021/ic50210a054research-articleACS PublicationsRequest reuse permissionsArticle Views322Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Receiver comparisons on an OFDM design for Doppler spread channels (2009)

Underwater acoustic channels induce large Doppler drifts that render intercarrier interference (ICI) for OFDM transmissions. Assuming that after proper Doppler compensation the residual ICI is limited to only direct neighbors, we propose an OFDM signal design that decouples channel estimation and data demodulation. We investigate eight receivers that are categorized into three groups: (i) three receivers that ignore the residual ICI, (ii) three receivers that are based on a basis expansion model (BEM) and pursue channel estimation independently along each basis, and (iii) two receivers that are based on discrete-path modeling. The receiver performance is compared based on data from the SPACE experiment conducted off the coast of Martha's Vineyard, Massachusetts, October 2008. The receiver based on the discrete-path modeling and a basis pursuit algorithm achieves the best performance while the receiver based on BEM and least-squares channel estimation performs the worst. The performance differences among different receivers drastically increase as the channel's Doppler spread and the signal constellation size increase. Interestingly, the BEM based receivers are often inferior to the ICI-ignorant counterparts, implying that the ability of ICI compensation could be limited by the estimation accuracy of the much increased number of model parameters.
A Common Phenotype Associated with Atherogenesis in Diverse Mouse Models of Vascular Lipid Lesions (2001)

The introduction of a range of different genetic modifications in mice results in altered lipoprotein metabolism and the development of vascular lipid lesions. At present, however, it is unclear to what extent the molecular events underlying lipid lesion formation are similar in these different mouse models of atherosclerosis. The aim of this study was to compare the protein expression pattern of lipid lesions from seven different mouse lines with varying susceptibility to vascular lipid lesion development, to determine to what extent lesions induced by different genetic interventions have a similar composition. The proteins we have measured, using quantitative immunofluorescence, are proteins whose expression is known to be modulated during atherogenesis in humans, including plasminogen activator inhibitor (PAI)-1, transforming growth factor (TGF)-beta 1, osteopontin and the macrophage marker CD11b. In all the mice lines we have investigated, PAI-1 was elevated wherever lesions developed. Active TGF-beta was depressed in the vessel wall of mice which developed lipid lesions, particularly in the intima. In contrast, TGF-beta 1 antigen (active plus latent TGF-beta 1) was increased at lesion sites. Accumulation of osteopontin and, with the marked exception of apolipoprotein(a) transgenic mice, tissue macrophages occurred at sites of lipid deposition in the vessel wall. Each lesion, irrespective of its size and the mouse strain in which it developed, had similar amounts of PAI-1, active TGF-beta and osteopontin per unit area of lesion. These data are consistent with a common phenotype accompanying atherogenesis, irrespective of the genetic basis of susceptibility.
Stimulus degradation impairs performance in a rodent continuous performance test (2021)

Abstract Sustained attention is a core cognitive domain that is often disrupted in neuropsychiatric disorders. Continuous performance tests (CPTs) are the most common clinical assay of sustained attention. In CPTs, participants produce a behavioral response to target stimuli and refrain from responding to non-target stimuli. Performance in CPTs is measured as the ability to discriminate between targets and non-targets. Rodent versions of CPTs (rCPT) have been developed and validated with both anatomical and pharmacological studies, providing a translational platform for understanding the neurobiology of sustained attention. In human studies, using degraded stimuli (decreased contrast) in CPTs impairs performance and patients with schizophrenia experience a larger decrease in performance compared to healthy controls. In this study, we tested multiple levels of stimulus degradation in a touchscreen version of the CPT in mice. We found that stimulus degradation significantly decreased performance in both males and females. The changes in performance consisted of a decrease in stimulus discrimination, measured as d’, and increases in hit reaction time and reaction time variability. These findings are in line with the effects of stimulus degradation in human studies. Overall, female mice demonstrated a more liberal response strategy than males, but response strategy was not affected by stimulus degradation. These data extend the utility of the mouse CPT by demonstrating that stimulus degradation produces equivalent behavioral responses in mice and humans. Therefore, the degraded stimuli rCPT has high translational value as a preclinical assay of sustained attention.
DEVELOPMENT OF MICRO NEEDLE-HEAD SLIDE VALVE UNIT FOR MICROFLUIDIC DEVICES (2003)

A novel micro needle-head slide microvalve unit is presented. It is actuated by the micro stepping motor for microfhtidic devices. The advantage of the design of this novel microvalve is to easily replace a micro needle-head and a various kinds of microactuator depending on users’ application. Its structure is very simple and compact. Its leakage test and stop flow test was demonstrated.
Improving the reactivity of hydrazine-bearing MRI probes for in vivo imaging of lung fibrogenesis (2019)

Pulmonary fibrosis (PF) is the pathologic accumulation of extracellular matrix components in lung tissue that result in scarring following chronic lung injury. PF is typically diagnosed by high resolution computed tomography (HRCT) and/or invasive biopsy. However, HRCT cannot distinguish old injury from active fibrogenesis. We previously demonstrated that allysine residues on oxidized collagen represent an abundant target during lung fibrogenesis, and that magnetic resonance imaging (MRI) with a small-molecule, gadolinium-containing probe, Gd-Hyd, could specifically detect and stage fibrogenesis in a mouse model. In this work, we present an improved probe, Gd-CHyd, featuring an <i>N</i>,<i>N</i>-dialkyl hydrazine which has an order of magnitude both greater reactivity and affinity for aldehydes. In a paired study in mice with bleomycin induced lung injury we show that the improved reactivity and affinity of Gd-CHyd results in significantly higher lung-to-liver contrast, <i>e.g.</i> 77% higher at 45 min post injection, and slower lung clearance than Gd-Hyd. Gd-CHyd enhanced MRI is >60-fold higher in bleomycin injured mouse lungs compared to uninjured mice. Collectively, our data indicate that enhancing hydrazine reactivity and affinity towards allysine is an effective strategy to significantly improve molecular MRI probes for lung fibrogenesis.
Test procedure for the prediction of water transport in polymer electrolyte fuel cells (2022)

Water plays a crucial role for the operation of polymer electrolyte fuel cells. The distribution and state of water in the membrane-electrode-assembly (MEA) not only impacts the performance of the cell, but also its degradation and freeze-start capability. It is therefore important to have a model that precisely predicts the distribution of water across the fuel cell for arbitrary inlet conditions. Unfortunately, water transport coefficients reported in the literature vary by orders of magnitude while operation conditions and other crucial properties of the cell are not precisely known. Furthermore, a large amount of data is simply outdated due to improvements in measurement techniques and setups as well as fuel cell components. In the present work, we have devised a test procedure for water transfer measurements with state of the art MEAs. In parallel, we have derived a semi-empirical model and parametrized it with measured data. The model allows predicting MEA water fluxes and profiles of temperature and concentration over a wide operation range, relevant for passenger as well as heavy duty automotive applications.
On the overhead-delay tradeoff in carrier sense collision channels (2005)

In this paper, we study the impact of delay constraints on the throughput of a queued multiple-access system. We model the channel as a collision channel with carrier sense to capture the inherent information sharing due to broadcast nature of the wireless channels. Since the queue state information is unknown to other nodes and a delay-bounded communication is desired, we show that a fraction of throughput is lost as protocol overhead. More importantly, we show that there is a tradeoff between protocol overhead and queuing delay; larger delays allowing smaller overheads. In addition, we show that larger network loads can also be used to reduce protocol overhead, which is in direct contrast of the behavior exhibited by commonly used medium access protocols
A Scalable 5–15 Gbps, 14–75 mW Low-Power I/O Transceiver in 65 nm CMOS (2008)

We present a scalable low-power I/O transceiver in 65 nm CMOS, capable of 5-15 Gbps operation over single-board and backplane FR4 channels with power efficiencies between 2.8-6.5 mW/Gbps. Nonlinear power-performance tradeoff is achieved by the use of scalable transceiver circuit blocks and joint optimization of the supply voltage, bias currents and driver power with data rate. Low-power operation is enabled by passive equalization through inductive link termination, active continuous-time RX equalization, global TX/RX clock distribution with on-die transmission lines, and low-noise offset-calibrated receivers.
Session Analysis using Plan Recognition (2017)

This paper presents preliminary results of our work with a major financial company, where we try to use methods of plan recognition in order to investigate the interactions of a costumer with the company's online interface. In this paper, we present the first steps of integrating a plan recognition algorithm in a real-world application for detecting and analyzing the interactions of a costumer. It uses a novel approach for plan recognition from bare-bone UI data, which reasons about the plan library at the lowest recognition level in order to define the relevancy of actions in our domain, and then uses it to perform plan recognition. We present preliminary results of inference on three different use-cases modeled by domain experts from the company, and show that this approach manages to decrease the overload of information required from an analyst to evaluate a costumer's session - whether this is a malicious or benign session, whether the intended tasks were completed, and if not - what actions are expected next.
Pentacoordinate iron tricarbonyl complexes of diphosphine ligands with bite angles greater than 120.degree. (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPentacoordinate iron tricarbonyl complexes of diphosphine ligands with bite angles greater than 120.degree.Charles P. Casey, Gregory T. Whiteker, Charles F. Campana, and Douglas R. PowellCite this: Inorg. Chem. 1990, 29, 18, 3376–3381Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://doi.org/10.1021/ic00343a023RIGHTS & PERMISSIONSArticle Views206Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (677 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection (2008)

It is known that protection against tuberculosis is mediated primarily by T helper type 1 (Th1) cells but the influence of the Th1/Th2 balance of a vaccination response on the subsequent protection and pathology during infection has not been studied in detail. We designed a panel of Ag85B-ESAT-6 subunit vaccines based on adjuvants with different Th1/Th2-promoting activities and studied cellular responses, bacterial replication and pathology in the lungs of mice infected with Mycobacterium tuberculosis. All vaccines induced cell-mediated and humoral responses but with markedly different interferon-gamma : interleukin-5 (IFN-gamma : IL-5) and immunoglobulin G1 (IgG1) : IgG2 ratios. The vaccines promoted different levels of control of bacterial replication with the most efficient protection being exerted by cationic liposomes containing monophosphoryl lipid A and low to completely absent immunity with conventional aluminium. The level of protection correlated with the amount of IFN-gamma produced in response to the vaccine whereas there was no inverse correlation with the level of IL-5. Characterizing a protective response was an accelerated recruitment of IL-17 and IFN-gamma-producing lymphocytes resulting in the early formation of granulomas containing clustered inducible nitric oxide synthase-activated macrophages. In comparison, non-protected mice exhibited a different inflammatory infiltrate rich in neutrophil granulocytes. This study indicates that the adjuvant component of a tuberculosis vaccine may be crucial in determining the kinetics by which effective granulomas, pivotal in controlling bacterial growth, are formed.
Continuous catalytic Friedel–Crafts acylation in the biphasic medium of an ionic liquid and supercritical carbon dioxide (2007)

Immobilisation of catalytically-active metal salts in ionic liquids, with extraction by supercritical carbon dioxide, affords continuous Friedel-Crafts acylation, with in situ-recycling of the catalyst.
Lung lobe modeling and segmentation with individualized surface meshes (2008)

An automated segmentation of lung lobes in thoracic CT images is of interest for various diagnostic purposes like the quantification of emphysema or the localization of tumors within the lung. Although the separating lung fissures are visible in modern multi-slice CT-scanners, their contrast in the CT-image often does not separate the lobes completely. This makes it impossible to build a reliable segmentation algorithm without additional information. Our approach uses general anatomical knowledge represented in a geometrical mesh model to construct a robust lobe segmentation, which even gives reasonable estimates of lobe volumes if fissures are not visible at all. The paper describes the generation of the lung model mesh including lobes by an average volume model, its adaptation to individual patient data using a special fissure feature image, and a performance evaluation over a test data set showing an average segmentation accuracy of 1 to 3 mm.
16th IHIW: Analysis of HLA Population Data, with updated results for 1996 to 2012 workshop data (AHPD project report) (2012)

We present here the results of the Analysis of HLA Population Data (AHPD) project of the 16th International HLA and Immunogenetics Workshop (16IHIW) held in Liverpool in May-June 2012. Thanks to the collaboration of 25 laboratories from 18 different countries, HLA genotypic data for 59 new population samples (either well-defined populations or donor registry samples) were gathered and 55 were analysed statistically following HLA-NET recommendations. The new data included, among others, large sets of well-defined populations from north-east Europe and West Asia, as well as many donor registry data from European countries. The Gene[rate] computer tools were combined to create a Gene[rate] computer pipeline to automatically (i) estimate allele frequencies by an expectation-maximization algorithm accommodating ambiguities, (ii) estimate heterozygosity, (iii) test for Hardy-Weinberg equilibrium (HWE), (iv) test for selective neutrality, (v) generate frequency graphs and summary statistics for each sample at each locus and (vi) plot multidimensional scaling (MDS) analyses comparing the new samples with previous IHIW data. Intrapopulation analyses show that HWE is rarely rejected, while neutrality tests often indicate a significant excess of heterozygotes compared with neutral expectations. The comparison of the 16IHIW AHPD data with data collected during previous workshops (12th-15th) shows that geography is an excellent predictor of HLA genetic differentiations for HLA-A, -B and -DRB1 loci but not for HLA-DQ, whose patterns are probably more influenced by natural selection. In Europe, HLA genetic variation clearly follows a north to south-east axis despite a low level of differentiation between European, North African and West Asian populations. Pacific populations are genetically close to Austronesian-speaking South-East Asian and Taiwanese populations, in agreement with current theories on the peopling of Oceania. Thanks to this project, HLA genetic variation is more clearly defined worldwide and better interpreted in relation to human peopling history and HLA molecular evolution.
An approach for automatic selecting of optimal data acquisition window for magnetic resonance coronary angiography (2009)

The purpose of this study is to develop an automated method without user interaction for the optimal placing of ROI for selecting optimal data acquisition window in coronary MRA. One of the major problems of magnetic resonance coronary angiography (MRCA) is the effective suppression of coronary motion due to respiration and cardiac contraction. To compensate for cardiac movement, data acquisition is generally limited to the coronary artery rest period mainly found during end-diastole. End-diastole is called cardiac rest period. Generally, cardiac rest period is decided by operator. Therefore it is subjective, and requires many experiences. As for setting region of interest right coronary is known as an appropriate region for determining cardiac rest period. We proposed a method that is based on the extraction of intensive change regions and the calculation of the correlation coefficient. We tested the algorithm for two sets of clinical MR images and the results are shown.
ChemInform Abstract: Inhibition of Electron‐Hole Recombination in Substitutionally Doped Colloidal Semiconductor Crystallites. (1988)

Abstract The important finding of laser photolysis and EPR measurements concerns the drastic retardation (from ca. 30 ns to minutes and hours) in the electron‐hole recombination rate by doping TiO 2 semiconductor particles (120 Å) with 0.5% Fe(III).
Comparative Analysis of Vascular Endothelial Growth Factor Receptors on Retinal and Aortic Vascular Endothelial Cells (1995)

Ischemic eye disease often results in ocular neovascularization, presumably due to the elaboration of growth factors. Diabetic retinopathy is a classic example in which dramatic retinal neovascularization arises after ischemic retinal damage. The characterization of vascular endothelial growth factor (VEGF) as an angiogenic molecule whose expression is markedly induced by hypoxia makes it a promising candidate for mediating ischemic retinal neovascularization. Thus, we have characterized the structure, binding, and regulation of VEGF receptors in bovine retinal (BREC) and aortic endothelial cells (BAEC). VEGF stimulated a 2.1-fold increase in BREC number and DNA content at 0.6 nmol/l VEGF (P < 1 x 10(-7)). Scatchard binding analysis demonstrated specific high-affinity VEGF receptors on BREC with a Kd of 4.9 +/- 0.6 x 10(-11) mmol/l, similar to that observed for BAEC at 5.1 +/- 0.4 x 10(-11) mmol/l. BREC, however, possess 1.5 x 10(5) high-affinity receptors/cell, threefold more than BAEC (P < 0.003) and more than any cell type reported previously. 125I-VEGF affinity cross-linking revealed complexes at 220 and 170 kDa in BREC, but only a 220-kDa band of lesser intensity in BAEC. Cross-linking was displaceable in a dose-dependent manner by VEGF (P < 0.01) but not by other hormones. Hypoxia increased VEGF receptor number 50% in BREC without altering affinity. Antiphosphotyrosine immunoblotting showed VEGF-stimulated tyrosine autophosphorylation of VEGF receptor bands at 225 and 220 kDa and another band at 80 kDa within 1 min.(ABSTRACT TRUNCATED AT 250 WORDS)