gebhart/patrepeval huggingface dataset:
Control of Longitudinal Flight Dynamics of a Flapping-Wing Micro Air Vehicle Using Time-Averaged Model and Differential Flatness Based Controller (2007)

This paper addresses the issue of flight control of high frequency time-varying dynamics of biologically motivated flapping-wing micro air vehicle (FWMAV). A control scheme based on time-averaging theory is presented for the control of longitudinal dynamics of FWMAV. The time averaging results in a simplified model which approximates the high frequency time varying dynamics of the original system. A differential flatness based non-linear controller is designed for the time-averaged system and successfully applied to the time-varying system for trajectory tracking.
Multi‐view reconstruction of dynamic real‐world objects and their integration in augmented and virtual reality applications (2017)

Abstract We present a flexible system for high‐quality three‐dimensional reconstruction of dynamic real‐world objects based on a modular multi‐camera capture setup. The proposed algorithmic pipeline aims at the acquisition and digitization of natural and realistic representations of real people that can be easily integrated into augmented and virtual reality applications. In this context, we discuss the reduction of mesh complexity as one of the key challenges for visualizing reconstructed three‐dimensional content with augmented and virtual reality glasses and demonstrate different fields of application.
Fast Spatiotemporal Smoothing of Calcium Measurements in Dendritic Trees (2012)

We discuss methods for fast spatiotemporal smoothing of calcium signals in dendritic trees, given single-trial, spatially localized imaging data obtained via multi-photon microscopy. By analyzing the dynamics of calcium binding to probe molecules and the effects of the imaging procedure, we show that calcium concentration can be estimated up to an affine transformation, i.e., an additive and multiplicative constant. To obtain a full spatiotemporal estimate, we model calcium dynamics within the cell using a functional approach. The evolution of calcium concentration is represented through a smaller set of hidden variables that incorporate fast transients due to backpropagating action potentials (bAPs), or other forms of stimulation. Because of the resulting state space structure, inference can be done in linear time using forward-backward maximum-a-posteriori methods. Non-negativity constraints on the calcium concentration can also be incorporated using a log-barrier method that does not affect the computational scaling. Moreover, by exploiting the neuronal tree structure we show that the cost of the algorithm is also linear in the size of the dendritic tree, making the approach applicable to arbitrarily large trees. We apply this algorithm to data obtained from hippocampal CA1 pyramidal cells with experimentally evoked bAPs, some of which were paired with excitatory postsynaptic potentials (EPSPs). The algorithm recovers the timing of the bAPs and provides an estimate of the induced calcium transient throughout the tree. The proposed methods could be used to further understand the interplay between bAPs and EPSPs in synaptic strength modification. More generally, this approach allows us to infer the concentration on intracellular calcium across the dendritic tree from noisy observations at a discrete set of points in space.
Synthesis, Pharmacological Investigation and Computational Studies on a Tricyclic Ergoline Analog with Selective Dopamine Autoreceptor Activity (1995)

The novel aminobenzindolone 8 was prepared and evaluated as a potential antipsychotic agent. The target compound was synthesized in eight steps starting from the tetrahydrobenzindolone 9. The key step of the synthesis was an electrophilic amination of the aromatic ketone 11 followed by reductive degradation when the diethoxymethyl group was employed for protection of the lactam nitrogen and also for the benzylic position 2a. Dopamine and serotonin receptor binding studies revealed 8 to be a potent and selective ligand at the D-2 autoreceptor (ki = 4.0 nM). Further in vivo studies including the GBL-test and locomotor activity measurements indicated agonistic activity of 8 at the prejunctional binding sites. Comparison of ab initio based molecular electrostatic isopotential maps corroborates our hypothesis that the dopamine structure 6, containing an intramolecular hydrogen bond donating effect of the meta-HO-group, represents the conformation which is active at the dopamine D-2 autoreceptor.
A Pilot Study Evaluating the Safety and Efficacy of AMD3100 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients with Advanced Hematological Malignancies. (2004)

Abstract Cytokine mobilized peripheral blood (MPB) has become the preferred allograft source for patients with advanced hematological malignancies. Procurement of MPB currently requires from 5 to 6 days of granulocyte colony stimulating factor (G-CSF) administration and is associated with some donor morbidity and high cost. Recent studies suggest G-CSF induces mobilization by indirectly targeting the interaction between the chemokine stromal derived factor 1 (SDF-1) and its receptor CXCR-4. Here we report preliminary results using a direct antagonist of the SDF-1/CXCR-4 interaction, AMD3100, as a single agent to procure MPB from allogeneic donors. Two HLA-identical siblings, both males aged 55 and 58, received one or two doses of AMD3100 at 240mcg/kg followed 4 hours later by leukapheresis (LP). After successful collection and a one week washout period, the same donors were re-mobilized using G-CSF at 10mcg/kg/day followed by LP commencing day 5. The target CD34+ cell dose following each agent was &gt;2.0x10e6/kg recipient weight. The results of the mobilizations and allograft composition are presented in the table. Results of Mobilization Agent AMD3100 G-CSF Donor 1 Donor 2 Donor 1 Donor 2 Days of Drug administration 2 2 6 5 # LP Procedures 2 1 2 1 Peak fold ↑ CD34 count in PB 7 6 17 25 CD34 dose (x10e6/kg) 2.6 2.1 2.9 5.7 CD3 dose (x10e8/kg) 4.9 1.5 1.3 1.3 CD4 dose (x10e8/kg) 3.1 1.0 0.9 0.9 CD8 dose (x10e8/kg) 1.7 0.4 1.0 0.4 CD56 dose (x10e7/kg) 3.4 2.1 2.2 1.8 Following AMD3100, donor 1 did not experience any drug related toxicity and donor 2 developed only grade 1 abdominal bloating. Both donors experienced grade 2 bone pain during G-CSF mobilization. The AMD3100 mobilized cells from donor 1 were transplanted into a 51 year old woman with AML following conditioning with cyclophosphamide (120mg/kg) and total body irradiation (single dose at 550cGy). Single agent cyclosporine was used for GVHD prophylaxis. She engrafted neutrophils &gt;500/ul promptly on day +11 and platelets &gt; 20,000/ul on day +14. A bone marrow biopsy performed on day +30 revealed an overall cellularity of 50% with normal trilineage hematopoiesis and full donor chimerism. By day 30, the peripheral blood CD3 count had reached 531/ul, CD4 count 305/ul, and CD8 count 211/ul. The CD4/8 ratio was 1.4. She is currently being followed as an outpatient and by day +39 is without evidence of GVHD. The allograft from the second donor was not given as the recipient’s disease progressed. This is the first demonstration that a chemokine antagonist can induce the rapid mobilization of a functionally competent hematopoietic allograft without causing significant toxicity. Accrual is ongoing and additional donor/recipient pairs will be presented.
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer (2021)

Splicing is a central RNA-based process commonly altered in human cancers; however, how spliceosomal components are co-opted during tumorigenesis remains poorly defined. Here we unravel the core splice factor SF3A3 at the nexus of a translation-based program that rewires splicing during malignant transformation. Upon MYC hyperactivation, SF3A3 levels are modulated translationally through an RNA stem-loop in an eIF3D-dependent manner. This ensures accurate splicing of mRNAs enriched for mitochondrial regulators. Altered SF3A3 translation leads to metabolic reprogramming and stem-like properties that fuel MYC tumorigenic potential in vivo. Our analysis reveals that SF3A3 protein levels predict molecular and phenotypic features of aggressive human breast cancers. These findings unveil a post-transcriptional interplay between splicing and translation that governs critical facets of MYC-driven oncogenesis.
Thinking Beyond the Device: An Overview of Human- and Equity-Centered Approaches for Health Technology Design (2023)

A shift in the traditional technocentric view of medical device design to a human-centered one is needed to bridge existing translational gaps and improve health equity. To ensure the successful and equitable adoption of health technology innovations, engineers must think beyond the device and the direct end user and must seek a more holistic understanding of broader stakeholder needs and the intended context of use early in a design process. The objectives of this review article are (<i>a</i>) to provide rationale for the need to incorporate meaningful stakeholder analysis and contextual investigation in health technology development and biomedical engineering pedagogy, (<i>b</i>) to review existing frameworks and human- and equity-centered approaches to stakeholder engagement and contextual investigation for improved adoption of innovative technologies, and (<i>c</i>) to present case studyexamples of medical device design that apply these approaches to bridge the gaps between biomedical engineers and the contexts for which they are designing.
Reduction of thioredoxin significantly decreases its partial specific volume and adiabatic compressibility (1992)

The partial specific volume and adiabatic compressibility were determined at several temperatures for oxidized and reduced Escherichia coli thioredoxin. Oxidized thioredoxin had a partial specific volume of 0.785-0.809 mL/g at the observed upper limit for all proteins whereas the partial specific volume of reduced thioredoxin was 0.745-0.755 mL/g, a value in the range found for a majority of proteins. The adiabatic compressibility of oxidized thioredoxin was also much larger (9.8-18 x 10(-12) cm2 dyne-1) than that of the reduced protein (3.8-7.3 x 10(-12)). Apart from the region immediately around the small disulfide loop, the structures of the oxidized (X-ray, crystal) and reduced protein (nuclear magnetic resonance, solution) are reported to be very similar. It would appear that alterations in the solvent layer in contact with the protein surface must play a major role in producing these large changes in the apparent specific volumes and compressibilities in this system. Some activities of thioredoxin require the reduced structure but are not electron transfer reactions. The large changes in physical parameters reported here suggest the possibility of a reversible metabolic control function for the SS bond.
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat (2009)

These data suggest that the ageing process in the ovary of the Sprague-Dawley rat is accompanied by an increased sympathetic tone of the ovary. Consequently, this sympathetic change could be related to a neuroendocrine-driven formation of a polycystic condition similar to that observed in the sympathetic-activated adult ovary.
Correlation of Structure and Magnetic Properties of Thin CoP Films (1988)

Thin, electroless films (<100 nm) were deposited on substrates, and the relationships between nucleation, microstructure, preferred orientation, internal stress, and magnetic properties of these deposits were investigated. The substrate treatment prior to plating (keeping the plating parameters constant) was found to have a profound effect on nucleation and growth, structure, internal stress, and magnetic properties of deposits. The magnetic properties of the deposits can be explained in terms of crystal, shape, and strain anisotropies of the structures. Shape anisotropy is the major parameter contributing to good in‐plane magnetic properties. A model for development of shape anisotropy of the crystallites is suggested.
Minimally invasive lag screw fixation of sacroiliac luxation/fracture using a dedicated novel instrument system: Apparatus and technique description (2017)

The SILIS addresses limitations associated with MIO of SIL/F, including maintenance of reduction throughout surgery along with reliable and accurate sacral screw placement. Distance from the X-ray source is the most effective protection against radiation. Use of the SILIS allows the surgical team to move away from the C-arm during fluoroscopy, thereby reducing personnel exposure to dangerous direct and back-scattered ionizing radiation.
An Efficient Eco-Planner for Autonomous Vehicles With Focus on Passengers Comfort (2022)

Speed planning is one of the tasks that a self-driving vehicle carries out. A complete planner should consider and balance passengers comfort, trip time and energy consumption. This paper proposes a computationally efficient global speed planner for autonomous vehicles that explicitly includes comfort as one of the main objectives. In particular, our approach considers the trip time as a user-specified constraint and optimizes a cost function that accounts for both energy consumption and comfort. Since passenger comfort plays a critical role for self driving vehicle, we propose a comfort model that captures different aspects: planar and vertical accelerations and the contribution of different frequency components. We test the algorithm on a realistic case study and we quantify the trade-off between energy consumption and comfort.
Aspartyl Protease Inhibitors as Anti-Filarial Drugs (2022)

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode, <i>Brugia malayi</i> and the endosymbiotic bacteria, <i>Wolbachia</i>. From the three hits, nelfinavir had the best potency with an IC<sub>50</sub> value of 7.78 µM, followed by ritonavir and lopinavir with IC<sub>50</sub> values of 14.3 µM and 16.9 µM, respectively. The three APIs have a direct effect on killing adult <i>B. malayi</i> after 6 days of exposure in vitro and did not affect the <i>Wolbachia</i> titers. Sequence conservation and stage-specific gene expression analysis identified Bm8660 as the most likely primary aspartic protease target for these drug(s). Immunolocalization using antibodies raised against the Bm8660 ortholog of <i>Onchocerca volvulus</i> showed it is strongly expressed in female <i>B. malayi</i>, especially in metabolically active tissues such as lateral and dorsal/ventral chords, hypodermis, and uterus tissue. Global transcriptional response analysis using adult female <i>B. pahangi</i> treated with APIs identified four additional aspartic proteases differentially regulated by the three effective drugs, as well as significant enrichment of various pathways including ubiquitin mediated proteolysis, protein kinases, and MAPK/AMPK/FoxO signaling. In vitro testing against the adult gastro-intestinal nematode <i>Trichuris muris</i> suggested broad-spectrum potential for these APIs. This study suggests that APIs may serve as new leads to be further explored for drug discovery to treat parasitic nematode infections.
Harmonic Standing-Wave Excitations of Simply-Supported Thick-Walled\n Hollow Elastic Circular Cylinders: Exact 3D Linear Elastodynamic Response (2020)

The forced-vibration response of a simply-supported isotropic thick-walled\nhollow elastic circular cylinder subjected to two-dimensional harmonic\nstanding-wave excitations on its curved surfaces is studied within the\nframework of linear elastodynamics. Exact semi-analytical solutions for the\nsteady-state displacement field of the cylinder are constructed using\nrecently-published parametric solutions to the Navier-Lam\\'{e} equation. Formal\napplication of the standing-wave boundary conditions generates three\nparameter-dependent $6\\times6$ linear systems, each of which can be numerically\nsolved in order to determine the parametric response of the cylinder's\ndisplacement field under various conditions. The method of solution is direct\nand demonstrates a general approach that can be applied to solve many other\nelastodynamic forced-response problems involving isotropic elastic cylinders.\nAs an application, and considering several examples, the obtained solution is\nused to compute the steady-state frequency response in a few specific low-order\nexcitation cases. In each case, the solution generates a series of resonances\nthat are in exact correspondence with a unique subset of the natural\nfrequencies of the simply-supported cylinder. The considered problem is of\ngeneral theoretical interest in structural mechanics and acoustics and more\npractically serves as a benchmark forced-vibration problem involving a\nthick-walled hollow elastic cylinder.\n
Joint selection of source and channel rate for VBR video transmission under ATM policing constraints (1997)

Variable bit-rate (VBR) transmission of video over ATM networks has long been said to provide substantial benefits, both in terms of network utilization and video quality, when compared with conventional constant bit-rate (CBR) approaches. However, realistic VBR transmission environments will certainly impose constraints on the rate that each source can submit to the network. We formalize the problem of optimizing the quality of the transmitted video by jointly selecting the source rate (number of bits used for a given frame) and the channel rate (number of bits transmitted during a given frame interval). This selection is subject to two sets of constraints, namely, (1) the end-to-end delay has to be constant to allow for real-time video display and (2) the transmission rate has to be consistent with the traffic parameters negotiated by user and network. For a general class of constraints, including such popular ones as the leaky bucket, we introduce an algorithm to find the optimal solution to this problem. This algorithm allows us to compare VBR and CBR under the same end-to-end delay constraints. Our results indicate that variable-rate transmission can increase the quality of the decoded sequences without increases in the end-to-end delay. Finally, we show that for the leaky-bucket channel, the channel constraints can be combined with the buffer constraints, such that the system is identical to CBR transmission with an additional, infrequently imposed constraint. Therefore, video quality with a leaky-bucket channel can achieve the same quality of a CBR channel with larger physical buffers, without adding to the physical delay in the system.
Toward a chemiresistive ammonia (NH3) gas sensor based on viral-templated gold nanoparticles embedded in polypyrrole nanowires (2014)

Preliminary studies toward the assembly of a gold-polypyrrole (PPy) peapod-like chemiresistive ammonia (NH3) gas sensors are presented. The proposed synthesis process will use electropolymerization to embed gold nanoparticles in polypyrrole nanowires. Viral-templating of gold nanoparticles and PPy electrodeposition via cyclic voltammetry are the focus of this investigation. A gold-binding M13 bacteriophage was used as a bio-template to assemble continuous chains of gold nanoparticles on interdigitated Pt working electrodes. The dimensions of the resulting nanowire-like structures were examined and the electrical resistance measured. PPy films were electropolymerized using an interdigitated planar, Pt electrode integrated counter and reference electrode. Morphological characterization of the polymer films was completed.
The colour preference control based on two-colour combinations (2008)

This paper proposes a framework of colour preference control to satisfy the consumer's colour related emotion. A colour harmony algorithm based on two-colour combinations is developed for displaying the images with several complementary colour pairs as the relationship of two-colour combination. The colours of pixels belonging to complementary colour areas in HSV colour space are shifted toward the target hue colours and there is no colour change for the other pixels. According to the developed technique, dynamic emotions by the proposed hue conversion can be improved and the controlled output image shows improved colour emotions in the preference of the human viewer. The psychophysical experiments are conducted to investigate the optimal model parameters to produce the most pleasant image to the users in the respect of colour emotions.
Notes on Adjoint Methods for 18.335 (2012)

Given the solution x of a discretized PDE or some other set of M equations parameterized by P variables p (design parameters, a.k.a. control variables or decision parameters), we often wish to compute
Fine pattern definition with atomic intermixing induced by focused ion beam and its application to x-ray mask fabrication (1991)

Mixing of double-layered Al-on-Au and Al-on-W structures by a focused ion beam (FIB) has been used to define fine patterns in Au and W layers and to demonstrate that the mixing spread is less than 0.1 μm. Since the mixed Al–Au alloy and Au have higher sputtering yield than Al, etching with 4-keV Xe ions engraves the FIB-defined pattern in the Au layer. This process yielded 0.2-μm-wide grooves in 20-nm Al/0.3-μm Au with a 50-keV Ga+ FIB of ∼5×1015/cm2. In the Al/W, Al is removed in H3PO4 leaving the mixed Al–W alloy, which acts as a durable mask in SF6 reactive ion etching of W with a selectivity of ∼80. This process enables the Ga+ FIB to define patterns less than 0.1 μm in 20-nm Al/0.3–0.5-μm W with a sensitivity of ∼1×1015/cm2. To demonstrate applicability of the above processes, patterns of x-ray masks were fabricated and transferred with synchrotron radiation to poly-methyl-methacrylate. Backscattering measurements of He ions and x-ray diffraction verify mixing occurs within the range of the ion. The process performance and its relation with the mixing kinetics are also discussed.
ChemInform Abstract: The Design, Synthesis, and Activity of Non‐ATP Competitive Inhibitors of pp60c‐src Tyrosine Kinase. Part 2. Hydroxyindole Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.