gebhart/patrepeval huggingface dataset:
Forecasting Automated Guided Vehicle Malfunctioning with Deep Learning in a 5G-Based Industry 4.0 Scenario (2021)

Industry 4.0 proposes the use of 5G networks to support intra-factory communications in replacement of current communication practices. 5G networks offer high availability, ultra-low latency, and high bandwidth, and allow the allocation of computational resources closer to the factories for reducing latency and response time. In addition, artificial intelligence can help in making smart decisions to improve the industrial and logistic processes. This work presents an interesting use case that combines Industry 4.0, 5G networks, and deep learning techniques for predicting the malfunctioning of an automatic guided vehicle (AGV) by exclusively using network traffic information and without needing to deploy any meter in the end-us-er equipment AGV and programmable logic controller (PLC). The AGV is connected through a 5G access to its PLC, which is deployed and virtualized in a multi-access edge computing infrastructure. A complete set of intensive experiments with a real 5G network and an industrial AGV were carried out in the 5TONIC environment, validating the effectiveness of this solution.
The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics (2019)

Given their recent emergence, virulence and genomic characteristics, the surveillance of clade 3 strains should be more highly prioritized.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques (2020)

Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with potent anti-inflammatory properties is currently being investigated in COVID-19 human clinical trials. Recent reports suggest that baricitinib may also have antiviral activity in limiting viral endocytosis. Here, we investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Viral shedding measured from nasal and throat swabs, bronchoalveolar lavages and tissues was not reduced with baricitinib. Type I IFN antiviral responses and SARS-CoV-2 specific T cell responses remained similar between the two groups. Importantly, however, animals treated with baricitinib showed reduced immune activation, decreased infiltration of neutrophils into the lung, reduced NETosis activity, and more limited lung pathology. Moreover, baricitinib treated animals had a rapid and remarkably potent suppression of alveolar macrophage derived production of cytokines and chemokines responsible for inflammation and neutrophil recruitment. These data support a beneficial role for, and elucidate the immunological mechanisms underlying, the use of baricitinib as a frontline treatment for severe inflammation induced by SARS-CoV-2 infection.
ChemInform Abstract: Molecular Yardsticks. Synthesis of Extended Equilibrium Transfer Alkylating Cross‐Link Reagents and Their Use in the Formation of Macrocycles. (1988)

Abstract Compounds (III) and (V) (prepared via the chelated Ti complex of (I)) both contain an α‐methylene with a good leaving group (‐SO2‐CH2‐CH2‐OH) close to the double bond combined with a strong activating oxo group for a Michael reaction.
Synthesis, Photophysics, and Photoresponse of Fullerene‐Based Azoaromatic Dyads (2005)

The synthesis and photophysical characterization of a series of fullerene-based, donor-acceptor dyads is presented, along with a description of their behavior as single molecular components in photovoltaic cells. The spectroscopic and photophysical properties of the dyads, investigated by steady-state fluorescence spectroscopy, pico- and nanosecond transient optical spectroscopy and time-resolved electron paramagnetic resonance (EPR) spectroscopy, revealed that the dyads undergo multiple-step energy transfer from the donor singlet excited state to the fullerene triplet excited state, which in turn decays to the donor triplet state. The inefficient formation of a charge-separated state, both in solution and in the solid state, translates into a poor photovoltaic performance of dyads 2 b-4 b if compared to that of dyad 1 b, in which photoinduced electron transfer is operative in the solid state. In addition, the results of the photophysical investigation suggested that the performance of the solar cells was also limited by the low-lying donor triplet excited state that acts as a photoexcitation energy sink.
Probing the Electronic Structure of [MoOS4]-Centers Using Anionic Photoelectron Spectroscopy (2002)

Using photodetachment photoelectron spectroscopy (PES) in the gas phase, we investigated the electronic structure and chemical bonding of six anionic [Mo(V)O](3+) complexes, [MoOX(4)](-) (where X = Cl (1), SPh (2), and SPh-p-Cl (3)), [MoO(edt)(2)](-) (4), [MoO(bdt)(2)](-) (5), and [MoO(bdtCl(2))(2)](-) (6) (where edt = ethane-1,2-dithiolate, bdt = benzene-1,2-dithiolate, and bdtCl(2) = 3,6-dichlorobenzene-1,2-dithiolate). The gas-phase PES data revealed a wealth of new electronic structure information about the [Mo(V)O](3+) complexes. The energy separations between the highest occupied molecular orbital (HOMO) and HOMO-1 were observed to be dependent on the O-Mo-S-C(alpha) dihedral angles and ligand types, being relatively large for the monodentate ligands, 1.32 eV for Cl and 0.78 eV for SPh and SPhCl, compared to those of the bidentate dithiolate complexes, 0.47 eV for edt and 0.44 eV for bdt and bdtCl(2). The threshold PES feature in all six species is shown to have the same origin and is due to detaching the single unpaired electron in the HOMO, mainly of Mo 4d character. This result is consistent with previous theoretical calculations and is verified by comparison with the PES spectra of two d(0) complexes, [VO(bdt)(2)](-) and [VO(bdtCl(2))(2)](-). The observed PES features are interpreted on the basis of theoretical calculations and previous spectroscopic studies in the condensed phase.
The socioeconomic impact of the Swiss Federal Institute for Snow and Avalanche Research (2004)

Research centers across the world spur scientific discovery and technological innovation. However, research institutes require financial support to conduct and expand their research. As an internationally recognized institution, the SLF has profound effects on the local economy, provides a range of educational benefits, and positively affects the people of Davos and Graubunden. We assessed its contributions in these areas by examining SLF records, surveys of Institute employees and conference participants, the SLF's educational programs, and the Avalanche Bulletin, and trends in avalanche damages.
Detection Assay for Replication-Competent Adenovirus by Concentration Passage and Real-Time Quantitative Polymerase Chain Reaction (qPCR) (2019)

The sensitivity of an assay for replication-competent adenoviruses (RCAs) can often be enhanced by biological amplification of the RCAs with serial passage. Here, we describe an extension of this technique, termed "concentration passage," in which RCA replicated during the first plating of the vector is collected and concentrated onto one-tenth of the original number of cells. This significantly increases the chances of detecting the RCAs. Combining this approach with the use of quantitative polymerase chain reaction (qPCR) for sensitive detection of the RCA E1 gene, we are able to reach levels of sensitivity of 1 IU of RCAs in 10<sup>11</sup> vector particles. The protocol described here is tailored for HuAd5 vectors using wild-type HuAd5 as the RCA surrogate. However, we have also adapted this technique with similar sensitivity to vectors based on other adenovirus serotypes. If other adenovirus serotypes are assayed, careful consideration should be given to the appropriate RCA surrogate. Strictly speaking, if the vector is propagated in HEK-293 or similar cell lines, the RCA surrogate should be a hybrid virus containing the HuAd5 E1 gene.
Structure-topology-property correlations of sodium phosphosilicate glasses (2015)

In this work, we investigate the correlations among structure, topology, and properties in a series of sodium phosphosilicate glasses with [SiO2]/[SiO2 + P2O5] ranging from 0 to 1. The network structure is characterized by (29)Si and (31)P magic-angle spinning nuclear magnetic resonance and Raman spectroscopy. The results show the formation of six-fold coordinated silicon species in phosphorous-rich glasses. Based on the structural data, we propose a formation mechanism of the six-fold coordinated silicon, which is used to develop a quantitative structural model for predicting the speciation of the network forming units as a function of chemical composition. The structural model is then used to establish a temperature-dependent constraint description of phosphosilicate glass topology that enables prediction of glass transition temperature, liquid fragility, and indentation hardness. The topological constraint model provides insight into structural origin of the mixed network former effect in phosphosilicate glasses.
Metal contamination evaluation of a TSV reveal process using direct Si/Cu grinding and residual metal removal (2015)

We evaluated the metal contamination generated by a through silicon via (TSV) reveal process using direct Si/Cu grinding and residual metal removal. To evaluate the metal contamination, a complementary metal oxide semiconductor (CMOS) + TSV wafer was prepared. The diameter and depth of the TSVs were 20 μm and 50 μm, respectively. TSV density was approximately 10%. The distance between each circuit component and TSV was 60 μm. After it was bonded to a glass support substrate, a TSV reveal process was performed by using direct Si/Cu grinding and residual metal removal. The wafer thickness after the TSV reveal process was 38 μm. After the TSV reveal process, the leakage current of the n+/p diodes and the capacitance-time characteristics of the n-type MOS capacitors were measured. The leakage current of the n+/p diodes was virtually unchanged after the TSV reveal process. In addition, the change in the generation lifetime of minority carriers determined by Zerbst analysis was less than 6%. These results demonstrate that the influence of the TSV reveal process on circuit components is small.
Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis (2014)

We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.
Demonstration that the local density approximation for trapped systems is exact in the thermodynamic limit (2007)

We present the full thermodynamics of a fluid confined by an arbitrary external potential based on the virial expansion of the grand potential. The fluid may be classical or quantum and it is assumed that interatomic interactions are pairwise additive. We indicate how the appropriate generalized volume and pressure variables, that replace the usual volume and hydrostatic pressure, emerge for a given confining potential in the thermodynamic limit. A discussion of the physical meaning and of the measurement of these variables is presented. We emphasize that this treatment yields the correct equation of state of the fluid and we give its virial expansion. We propose an experiment to measure the heat capacity, so that with this quantity and the equation of state, the complete thermodynamics of the system may be extracted. As a corollary, we find that the so-called {\it local density approximation} for these systems follows in the thermodynamic limit, although we also point out that it cannot be used indiscriminately for all local variables. Along the text we discuss the relevance of these findings in the description of the currently confined ultracold gases.
NADP, corepressor for the Bacillus catabolite control protein CcpA (1998)

Expression of the alpha-amylase gene (amyE) of Bacillus subtilis is subject to CcpA (catabolite control protein A)-mediated catabolite repression, a global regulatory mechanism in Bacillus and other Gram-positive bacteria. To determine effectors of CcpA, we tested the ability of glycolytic metabolites, nucleotides, and cofactors to affect CcpA binding to the amyE operator, amyO. Those that stimulated the DNA-binding affinity of CcpA were tested for their effect on transcription. HPr-P (Ser-46), proposed as an effector of CcpA, also was tested. In DNase I footprint assays, the affinity of CcpA for amyO was stimulated 2-fold by fructose-1,6-diphosphate (FDP), 1.5-fold by oxidized or reduced forms of NADP, and 10-fold by HPr-P (Ser-46). However, the triple combinations, CcpA/NADP/HPr-P (Ser-46) and CcpA/FDP/HPr-P (Ser-46) synergistically stimulated DNA-binding affinity by 120- and 300-fold, respectively. NADP added to CcpA specifically stimulated transcription inhibition of the amyE promoter by 120-fold. CcpA combined with HPr (Ser-46) inhibited transcription from the amyE promoter, but it also inhibited several control promoters. FDP did not stimulate transcription inhibition by CcpA nor did the triple combinations. The finding that NADP had little effect on CcpA DNA binding but increased the ability of CcpA to inhibit transcription suggests that catabolite repression is not simply caused by CcpA binding amyO but rather a result of interactions with the transcription machinery enhanced by NADP.
Satellite navigation: Present and future (2011)

The Global Positioning System serves one billion civil users with applications including: navigation for cars, aircraft, ships, spacecraft, pedestrians and emergency services; time transfer for telecommunications, finance and power delivery; and a breadth of scientific uses. Cognizant of this utility, the Russians are rejuvenating their satellite navigation system, and new systems are being fielded by China, Japan, India and Europe. Taken together, this Global Navigation Satellite System will provide geometric diversity with over one hundred navigation satellites all with triple frequency diversity for civil use. This paper and talk will briefly describe the technology with a focus on aviation applications.
Control of glycolysis in contracting skeletal muscle. II. Turning it off (2002)

Glycolytic flux in muscle declines rapidly after exercise stops, indicating that muscle activation is a key controller of glycolysis. The mechanism underlying this control could be 1) a Ca(2+)-mediated modulation of glycogenolysis, which supplies substrate (hexose phosphates, HP) to the glycolytic pathway, or 2) a direct effect on glycolytic enzymes. To distinguish between these possibilities, HP levels were raised by voluntary 1-Hz exercise, and glycolytic flux was measured after the exercise ceased. Glycolytic H(+) and ATP production were quantified from changes in muscle pH, phosphocreatine concentration, and P(i) concentration as measured by 31P magnetic resonance spectroscopy. Substrate (HP) and metabolite (P(i), ADP, and AMP) levels remained high when exercise stopped because of the occlusion of blood flow with a pressure cuff. Glycolytic flux declined to basal levels within approximately 20 s of the end of exercise despite elevated levels of HP and metabolites. Therefore, this flux does not subside because of insufficient HP substrate; rather, glycolysis is controlled independently of glycogenolytic HP production. We conclude that the inactivation of glycolysis after exercise reflects the cessation of contractile activity and is mediated within the glycolytic pathway rather than via the control of glycogen breakdown.
Comparison of measurements of phase velocity in human calcaneus to Biot theory (2005)

Biot's theory for elastic propagation in porous media has previously been shown to be useful for modeling the dependence of phase velocity on porosity in bovine cancellous bone in vitro. In the present study, Biot's theory is applied to measurements of porosity-dependent phase velocity in 53 human calcanea in vitro. Porosity was measured using microcomputed tomography for some samples (n = 23) and estimated based on bone mineral densitometry for the remaining samples (n = 30). The phase velocity at 500 kHz was measured in a water tank using a through-transmission technique. Biot's theory performed well for the prediction of the dependence of sound speed on porosity. The trend was quasilinear, but both the theory and experiment show similar slight curvature. The root mean square error (RMSE) of predicted versus measured sound speed was 15.8 m/s.
Alterations in collagen fiber crimp morphology with accelerated cyclic loading and transvalvular pressure fixation in porcine aortic valves (2002)

It is known that changes in the collagen fiber orientation of porcine bioprosthetic heart valves (PBHV) occur with (i) cyclic loading and (ii) fixation pressure. These changes correlate to alterations in biaxial extensibility, as reported by Wells et al. (2002). It is hypothesized that the increased collagen fiber alignment detected by small angle light scattering in (i) and (ii) is either due to the gross fiber splay, or a decrease in the colllagen fiber crimp (i.e. increase in crimp period). To address this hypothesis, we examined the changes in collagen fiber crimp morphology of PBHVs fixed at 0, 1, 2, and 4 mmHg transvalvular pressure, as well as 0 and 4 mmHg fixed PBHV following 0, 1/spl times/10/sup 6/, 50/spl times/10/sup 6/, 200/spl times/10/sup 6/, and 500/spl times/10/sup 6/ in vitro accelerated test cycles. Fast Fourier transform analysis of polarized light micrographs was used to calculate the collagen fiber crimp period. As PBHVs were fixed at increasing pressures, it was found that the crimp period increases from 15.2 /spl mu/m at 0 mmHg to 21.4 /spl mu/m at 4 mmHg. Additionally, a 65% increase in crimp period was observed between 0-50/spl times/10/sup 6/ cycles in the 0 mmHg fixed valves, while only an 18% increase in the 4 mmHg fixed valves over the same cycle duration. We conclude that decreasing collagen crimp is a primary mechanism contributing to PBHV cyclic fatigue damage.
ChemInform Abstract: Additive and Solvent Effects on SmI2 Reductions: The Effects of Water and DMPU. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Solutions for 80 km DWDM Systems (2015)

We review currently discussed solutions for 80 km DWDM transmission targeting inter data-center connections at 100G and 400G line rates. PDM-64QAM, PAM4 and DMT are investigated, while the focus lies on directly detected solutions.
Reversible Electropolymerization of Nickel Complexes Based on Redox‐Mediated Ligand Exchange (2016)

Abstract Controlled and reversible ligand exchange reactions are useful tools for modulating reactivity of transition metal complexes. Here, we present a reversible electropolymerization of nickel azopyridine (azpy) complexes based on the redox‐controlled diimine ligand exchange reaction. Upon a single electron reduction, (azpy)NiBr 2 disproportionates to afford (azpy) 2 Ni and a [NiBr 4 ] 2− , while in situ 1 e − oxidation of this mixture leads to complete restoration of the original complex. Reversible intermetallic ligand exchange is also demonstrated between nickel and cobalt or iron azopyridine complexes. This facile and quantitative ligand exchange reaction was utilized to develop a reversible electropolymerization strategy to generate nickel metallopolymers containing redox‐active azobispyridine ligands.
Growth and optical properties of self-assembled type II GaSb/GaAs quantum dots (2002)

We report the realization of quantum-sized GaSb dots, of small diameter (/spl sim/25 nm), on GaAs by molecular beam epitaxy in the Stranski-Krastanow growth mode. With the deposition of 3.1 mono-layers (MLs) GaSb, the average diameter and height of GaSb quantum dot (QD) are 26 nm and 6.2 nm, respectively. In addition, density control was systematically achieved between 2.6/spl times/10/sup 9/ and 1.2/spl times/10/sup 10/ cm/sup -2/ by carefully choosing the amount of GaSb deposited from 2.5 to 3.1 ML. The growth mechanism are discussed in detail. Also, we identify the QD luminescence by photoluminescence obtained at different excitation energies and densities. We show how for these structures not only the spectral position of peaks, but also their relative intensities are critically dependent upon the density of photo-generated carriers. Photoluminescence excitation (PLE) measurements confirm our assignment of the QD related peaks and a feature 25-27 meV higher in energy than the PLE detection energy is discussed in terms of phonon relaxation.
Figure S4 from BET Inhibitors Suppress ALDH Activity by Targeting <i>ALDH1A1</i> Super-Enhancer in Ovarian Cancer (2023)

&lt;p&gt;BRD4 directly targets stem-related genes in ovarian cancer cells, and their expression is suppressed by the BET inhibitor JQ1.&lt;/p&gt;
Surface Representation of Native SARS-CoV M<sup>pro</sup> and Inhibitor Complexes (2015)

&lt;div&gt;&lt;p&gt;(A) Surface representation of conserved substrate-binding pockets of five CoV M&lt;sup&gt;pro&lt;/sup&gt;s. Background is SARS-CoV M&lt;sup&gt;pro&lt;/sup&gt;. Red: identical residues among the five CoV M&lt;sup&gt;pro&lt;/sup&gt;s; magenta: substitution in one CoV M&lt;sup&gt;pro&lt;/sup&gt;; orange: substitution in two CoV M&lt;sup&gt;pro&lt;/sup&gt;s. The S1, S2, S4, and S1′ subsites and residues forming the substrate-binding pocket are labeled.&lt;/p&gt;\n &lt;p&gt;(B) Surface representation of SARS-CoV M&lt;sup&gt;pro&lt;/sup&gt; (blue) complexed with N1 (green). Water molecules are shown as red spheres. The P1–P5 and P1′ groups and residues forming the substrate-binding pocket are labeled.&lt;/p&gt;\n &lt;p&gt;(C) Surface representation of SARS-CoV M&lt;sup&gt;pro&lt;/sup&gt; (blue) in complex with N3 (green). Labels are the same as in &lt;a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030324#pbio-0030324-g002" target="_blank"&gt;Figure 2&lt;/a&gt;B.&lt;/p&gt;&lt;/div&gt;
Real-Time Plane-Sweeping Stereo with Multiple Sweeping Directions (2007)

Recent research has focused on systems for obtaining automatic 3D reconstructions of urban environments from video acquired at street level. These systems record enormous amounts of video; therefore a key component is a stereo matcher which can process this data at speeds comparable to the recording frame rate. Furthermore, urban environments are unique in that they exhibit mostly planar surfaces. These surfaces, which are often imaged at oblique angles, pose a challenge for many window-based stereo matchers which suffer in the presence of slanted surfaces. We present a multi-view plane-sweep-based stereo algorithm which correctly handles slanted surfaces and runs in real-time using the graphics processing unit (GPU). Our algorithm consists of (1) identifying the scene's principle plane orientations, (2) estimating depth by performing a plane-sweep for each direction, (3) combining the results of each sweep. The latter can optionally be performed using graph cuts. Additionally, by incorporating priors on the locations of planes in the scene, we can increase the quality of the reconstruction and reduce computation time, especially for uniform textureless surfaces. We demonstrate our algorithm on a variety of scenes and show the improved accuracy obtained by accounting for slanted surfaces.
Process Development for the Sulfonamide Herbicide Pyroxsulam (2008)

The development of a manufacturing process for the initial commercial production of pyroxsulam sulfonamide herbicide is described. The process encompasses seven reaction steps, and includes a new route to 4-(trifluoromethyl)pyridines, a scaleable method of lithiating a pyridine intermediate, and a sulfilimine-catalyzed formation of a sulfonamide.