gebhart/patrepeval huggingface dataset:
A Study of Lagrangean Decompositions and Dual Ascent Solvers for Graph Matching (2017)

We study the quadratic assignment problem, in computer vision also known as graph matching. Two leading solvers for this problem optimize the Lagrange decomposition duals with sub-gradient and dual ascent (also known as message passing) updates. We explore this direction further and propose several additional Lagrangean relaxations of the graph matching problem along with corresponding algorithms, which are all based on a common dual ascent framework. Our extensive empirical evaluation gives several theoretical insights and suggests a new state-of-the-art anytime solver for the considered problem. Our improvement over state-of-the-art is particularly visible on a new dataset with large-scale sparse problem instances containing more than 500 graph nodes each.
Evaluation of Digital Image Correlation Techniques for the Determination of Coefficients of Thermal Expansion for Thin Reinforced Polymers (2018)

Considering the application specific temperature loads microelectronic packages have to endure, thermal management plays a major role for reliability evaluations. A key aspect of thermal management is the assessment of mechanical stresses arising from the thermal mismatch of polymeric and metallic regimes within a given package. Generally, these material classes exhibit an entirely different thermal expansion behavior. In order to validate new designs of microelectronic packages and assess their reliability, a precise determination of the coefficients of thermal expansion (CTE) is necessary. However, modern polymeric materials in power electronics are extremely thin and may also exhibit an anisotropic material behavior, yet Digital Image Correlation (DIC) systems enable the contactless and precise measurement of thermally induced strains of these materials. Within the scope of this research work two DIC systems are employed and compared, a multi-use DIC system and a specialized DIC system, which is specifically designed for CTE measurement. To this end, an anisotropic FR4-prepreg material and the corresponding pure epoxy resin (isotropic) are examined using both DIC systems. Furthermore, Thermo-Mechanical-Analysis (TMA) is used as reference measurement for the isotropic epoxy material. The collected results are evaluated and compared against each other.
Alteration of Amine Oxidase Activity in the Adipose Tissue of Obese Subjects (2004)

Although they already exhibited several signs of endocrino-metabolic disorders, the obese men did not exhibit the increase in blood markers of oxidative stress or the decrease in antioxidant defenses reported to occur in very obese or diabetic subjects. The reduced MAO and the unchanged SSAO activities found in obesity suggest that these hydrogen peroxide-generating enzymes expressed in adipocytes are probably not involved in the onset of the oxidative stress found in severe obesity and/or in its complications.
An error concealment scheme for entire frame losses based on H.264/AVC (2006)

In this paper, an error concealment algorithm is proposed to conceal an entirely lost frame in an H.264/AVC compressed video bitstream. For a lost frame, the algorithm reconstructs the lost motion information of this frame based on its temporal neighbors. The algorithm is block based and thus has low computation and implementation complexity. It is designed for those hard-to-conceal video sequences, which have abundant active and chaotic motions. Experimental results show that the algorithm compares favorably to other simple error concealment algorithms
A database of 660 peptide ion cross sections: Use of intrinsic size parameters for bona fide predictions of cross sections (1999)

An ion trap/ion mobility/time-of-flight mass spectrometry technique has been used to measure collision cross sections for 660 peptide ions generated by tryptic digestion of 34 common proteins. Measured cross sections have been compiled into a database that contains peptide molecular weight and sequence information. The database is used to generate average intrinsic contributions to cross section (size parameters) for different amino acid residues by solving systems of equations that relate the unknown contributions of individual residues to the sequences and cross sections of database peptides. Size parameters are combined with information about amino acid composition to calculate cross sections for database peptides. Bona fide cross section predictions (made prior to measurement) for peptides observed in tryptic digests of sperm whale myoglobin and yeast enolase are made. Eight of 10 predicted cross sections are within 2% of the experimental values and all 10 are within 3.2%. The utility of size parameters for cross section prediction is explored and discussed.
Pep-1 transporte des protéines dans les cellules de mammifères (2002)

International audience
Silver-coated silicon pillar photonic crystals: Enhancement of a photonic band gap (2003)

For a two-dimensional lattice of Si pillars it is shown both experimentally and theoretically that a photonic band gap for the light polarized perpendicular to pillars can be strongly enhanced by means of a silver coating of the pillars. A sizable omnidirectional photonic band gap is demonstrated for both square and triangular lattice of silver-coated Si pillars in the near-infrared and visible spectral range.
Lifing Requirement Based Turbine Airfoil Mass Estimation Method in Conceptual Aero-Engine Design (2011)

The presented paper describes a method developed by MTU Aero Engines to estimate the mass of turbine blades during multi-disciplinary conceptual design studies based on a prescribed airfoil lifetime [1, 2]. For a given material, the target lifetime can be translated into a maximally allowable material temperature and stress level. While the latter has to be maintained by an appropriate mechanical design of the turbine blades, the material temperature needs to be established by sufficient cooling air. The predominant life-limiting effects are taken into account to determine the allowable temperatures and stresses as an accumulation of the varying operating condition over a flight cycle. The applicable stress levels are then used to calculate the necessary radial area distribution of the airfoil and by this a prediction of its mass is possible. Furthermore, the methodology estimates the required amount of cooling air per airfoil cascade from the computed material temperatures. Example calculations are presented and discussed which illustrate design trends and the benefits which are gained from the proposed method.
Modularis: Modular Relational Analytics over Heterogeneous Distributed Platforms (2020)

The enormous quantity of data produced every day together with advances in data analytics has led to a proliferation of data management and analysis systems. Typically, these systems are built around highly specialized monolithic operators optimized for the underlying hardware. While effective in the short term, such an approach makes the operators cumbersome to port and adapt, which is increasingly required due to the speed at which algorithms and hardware evolve. To address this limitation, we present Modularis, an execution layer for data analytics based on sub-operators, i.e.,composable building blocks resembling traditional database operators but at a finer granularity. To demonstrate the advantages of our approach, we use Modularis to build a distributed query processing system supporting relational queries running on an RDMA cluster, a serverless cloud platform, and a smart storage engine. Modularis requires minimal code changes to execute queries across these three diverse hardware platforms, showing that the sub-operator approach reduces the amount and complexity of the code. In fact, changes in the platform affect only sub-operators that depend on the underlying hardware. We show the end-to-end performance of Modularis by comparing it with a framework for SQL processing (Presto), a commercial cluster database (SingleStore), as well as Query-as-a-Service systems (Athena, BigQuery). Modularis outperforms all these systems, proving that the design and architectural advantages of a modular design can be achieved without degrading performance. We also compare Modularis with a hand-optimized implementation of a join for RDMA clusters. We show that Modularis has the advantage of being easily extensible to a wider range of join variants and group by queries, all of which are not supported in the hand-tuned join.
Supplementary Table S5 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers (2023)

&lt;p&gt;FISH probes.&lt;/p&gt;
Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial (2011)

Both symptom onset-to-balloon time and hospital door-to-balloon time are strongly associated with 90-day mortality following STEMI. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00091637.
Age-Dependent Changes in FasL (CD95L) Modulate Macrophage Function in a Model of Age-Related Macular Degeneration (2013)

Age modulates FasL function where increased MMP cleavage leads to a loss of function in the eye. The released form of FasL (sFasL) preferentially induces the migration of proangiogenic M2 macrophages into the laser lesions and increases proangiogenic cytokines promoting CNV. FasL may be a viable target for therapeutic intervention in aged-related neovascular disease.
ACS Chemical Neuroscience Molecule Spotlight on Latuda (Lurasidone; SM-13,496) (2011)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTACS Chemical Neuroscience Molecule Spotlight on Latuda (Lurasidone; SM-13,496)Corey R. HopkinsView Author Information Department of Pharmacology and Vanderbilt Program in Drug Discovery, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232-6600, United StatesCite this: ACS Chem. Neurosci. 2011, 2, 2, 58–59Publication Date (Web):February 16, 2011Publication History Received20 December 2010Accepted20 December 2010Published online16 February 2011Published inissue 16 February 2011https://pubs.acs.org/doi/10.1021/cn1001123https://doi.org/10.1021/cn1001123editorialACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1803Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (741 KB) Get e-AlertscloseSUBJECTS:Antagonists,Circuits,Diseases and disorders,Receptors,Schizophrenia Get e-Alerts
Proposal of load estimation method using plastic strain under fatigue fracture surface (2019)

Striations are observed on the fracture surface of the broken metal material, and the working load has been estimated from its interval. However, striation is not always observed, and in that case, the fatigue crack propagation rate cannot be estimated by the conventional method. At the fatigue crack tip, the plastic zone formed during tensile loading is compressed into the surrounding elastic zone during unloading. From this fact, it is considered that the crack propagation rate is closely related to plastic strain distribution. In this study, we used a Fe-3Al bcc single crystalline alloy and the plastic strain just under the fracture surface was investigated. Using ECCI method and EBSD method in the different stress intensity factor range, the change of the inclination of dislocation wall near the fracture surface and the crystal orientation gradient is measured, and the possibility of the estimation of the applied stress using the microstructure near the fatigue fracture surface is examined. As for the dislocation structure, it is shown that there is a boundary where the dislocation wall tilts when a new slip system starts to work as the observation region approaches the fracture surface. And, it was proven that the distance from the fracture surface to the boundary changed with the ΔK value. And, this paper indicates the possibility of obtaining useful information for fatigue fracture analysis such as ΔK by investigating the region in which dislocation wall exists. As for the crystal orientation gradient, there was a decrease of GROD value near the fracture surface, and this seemed to be the effect of the cyclic plasticity region. It is also shown that the GROD values can be qualitatively evaluated by the difference of ΔK values.
The Apparent Constant-Phase-Element Behavior of a Disk Electrode with Faradaic Reactions (2007)

International audience
Space-Vector-Equalized Predictive Current Control Scheme for the Modular Multilevel Converter With Improved Steady-State Performance (2022)

A large number of control options and steady-state tracking errors are two main challenges for model predictive control in the modular multilevel converter (MMC). To solve these issues, each arm of the three-phase MMC is considered as a whole, and a space-vector-equalized predictive current control scheme is proposed for the three-phase MMC in this article. First, eight equalized space vectors are involved, and only six nonzero vectors are evaluated in each period. As a result, the number of evaluated control options can be significantly reduced. Then, two optimal vectors are selected, and their dwell times are calculated based on the predicted output currents of the MMC. Furthermore, the compensation terms are designed and added to the dwell times so that the steady-state performance can be improved by the proposed scheme. Experimental results show that the proposed scheme provides fast dynamic response and outstanding steady-state performance for the three-phase MMC.
Data from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;Natural killer (NK) cells and T cells are key effectors of antitumor immune responses and major targets of checkpoint inhibitors. In multiple cancer types, we find that the expression of Wnt signaling potentiator R-spondin genes (e.g., &lt;i&gt;RSPO3&lt;/i&gt;) is associated with favorable prognosis and positively correlates with gene signatures of both NK cells and T cells. Although endothelial cells and cancer-associated fibroblasts comprise the R-spondin 3–producing cells, NK cells and T cells correspondingly express the R-spondin 3 receptor LGR6 within the tumor microenvironment (TME). Exogenous expression or intratumor injection of R-spondin 3 in tumors enhanced the infiltration and function of cytotoxic effector cells, which led to tumor regression. NK cells and CD8&lt;sup&gt;+&lt;/sup&gt; T cells independently and cooperatively contributed to R-spondin 3–induced control of distinct tumor types. The effect of R-spondin 3 was mediated in part through upregulation of MYC and ribosomal biogenesis. Importantly, R-spondin 3 expression enhanced tumor sensitivity to anti–PD-1 therapy, thereby highlighting new therapeutic avenues.&lt;/p&gt;Significance:&lt;p&gt;Our study identifies novel targets in enhancing antitumor immunity and sensitizing immune checkpoint inhibition, which provides a rationale for developing new immunotherapies against cancers. It also offers mechanistic insights on Wnt signaling–mediated modulation of anticancer immunity in the TME and implications for a putative R-spondin–LGR6 axis in regulating NK-cell biology.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 2945&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Embedded RF Filters for WLAN and Bluetooth Applications (2005)

This paper discusses the design and integration of RF filters in multilayer organic substrate. Using a methodic approach, several low-pass and band-pass filters have been designed, fabricated and fully characterized. The electrical analysis clearly indicates, which of the low-pass filters is less susceptible to process variations and therefore more appropriate for high volume manufacturing. It is shown that these filters provide electrical performance similar to their commercially available ceramic counterparts while using relatively smaller real estate. All filters are fabricated in the innermost layers of a multilayer organic package substrate with embedded passives capability.
A Single-Stage Microinverter Without Using Eletrolytic Capacitors (2012)

This paper presents a new microinverter topology that is intended for single-phase grid-connected PV systems. The proposed microinverter topology is based on a flyback converter, where an extra switch is added to separate the decoupling capacitor from the PV Module, which allows for a high voltage and voltage ripples across its terminals. This results in reducing the power decoupling required capacitance. In this manner, long life-time low power density film capacitors can be used instead of life-time limited high power density electrolytic capacitors, resulting in remarkable increase of microinverter's lifespan. The main advantages of the proposed topology are summarized as: 1) eliminating the double-frequency power ripple using a small film capacitor; 2) using long lifetime film capacitors, which will improve the reliability of the inverter; and 3) requiring no additional circuitry to manage the transformer leakage energy. A 100-W microinverter prototype was built to verify the proposed topology. Experimental results show that the proposed topology and its control scheme can realize the power decoupling, while maintaining very good conversion efficiency numbers.
The stone skeleton: structural engineering of masonry architecture (1996)

Preface 1. Introduction 2. Structural theory of masonry 3. Domes 4. The masonry vault 5. Some structural elements 6. Towers and bells 7. Spires 8. Some historical notes Bibliography Index.
Delayed DMSO Administration Protects the Kidney from Mercuric Chloride-Induced Injury (2004)

Reactive oxygen species are implicated as mediators of tissue damage in ischemic and toxic acute renal failure. Whereas many agents can inhibit renal ischemic injury, only hepatocyte growth factor, melatonin, N-acetylcysteine, and DMSO inhibit injury after mercuric chloride administration. Although it has been suggested that DMSO may chelate the mercuric ion, more recent studies suggest that it has anti-inflammatory and antioxidant effects. Acute renal failure was induced by 5 mg/kg subcutaneous injection of mercuric chloride in BALB/c mice. DMSO (3.8 ml/kg, 40% in PBS) or vehicle (PBS) was injected intraperitoneally at 0 and 24 h after mercuric chloride injection, or DMSO treatment was delayed 3 or 5 h. DMSO prevented increases in serum creatinine and tubular damage at 24 and 48 h. When DMSO treatment was delayed by 3 h, it was still beneficial; however, with a 5-h delay, the histology score and serum creatinine were not significantly decreased. DMSO partially prevented a mercuric chloride-induced decrease in glutathione peroxidase activity and completely prevented the transient decrease in superoxide dismutase activity. Neither mercuric chloride nor DMSO affected catalase activity significantly. For investigating possible effects of DMSO on cellular mercuric ion uptake, MDCK cells that were transfected with human organic anion transporter-1 were used. 203Hg uptake was inhibited 90% by N-acetylcysteine but only 5% by DMSO, indicating that the effect of DMSO is not related to chelating mercuric ion or inhibiting its uptake. It is concluded that DMSO acts in part as an antioxidant to inhibit mercuric chloride-induced acute renal injury.
Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations (2017)

This study reveals ANGPT2 as a new susceptibility gene for nAMD and PCV, and it may affect disease susceptibility in association with CFH. Thus, this report provides new insights into the genetic architecture of nAMD and PCV.
In vivo Safety and Immunoactivity of Oncolytic Jurona Virus in Hepatocellular Carcinoma: A Comprehensive Proteogenomic Analysis (2022)

ABSTRACT Oncolytic viruses can effectively unwrap a multimodal anti-tumor activity, encompassing a selective tumor cell killing and promoting a systemic anti-tumor immunity, making them a formidable foe against cancer. Among these, several members of the Rhabdoviridae family are particularly attractive as oncolytic agents due to their natural tumor selectivity and non-pathogenicity in humans. In this study, we demonstrated that intratumorally (IT) administration of Jurona virus (JURV), a novel oncolytic Rhabdovirus, induces dynamic tumor regression in human HCC xenograft and syngeneic models. Our data shows that IT injections of JURV trigger the recruitment and activation of cytotoxic T (CTLs) and decrease the tumor-associated macrophages (TAM) infiltration leading to tumor growth delay in both local and distant murine HCC tumors in a syngeneic model. Moreover, when administered concomitantly, JURV and anti-PD-1 therapy profoundly modulate the tumor microenvironment (TME) via enhanced infiltration of CTLs, suggesting that immune checkpoint blockade therapy could potentiate the immunomodulatory effect of JURV and potentially provide durable anti-tumor immunity. Our analysis of the molecular and cellular mechanism of JURV-medicated anti-cancer activity unveiled that JURV and anti-PD-1 antibodies activate different effectors of the immune system but have complementary anti-tumor activities. Furthermore, our results indicate that the abscopal effect induced by JURV is likely mediated by the mechanism regulating the T helper cell responses. Our work supports the further development of JURV as a novel immunovirotherapy platform for hepatocellular carcinoma.
Significantly Improved Analytical Sensitivity of Lateral Flow Immunoassays by Using Thermal Contrast (2012)

Der thermische Kontrast, der beim Erhitzen von Goldnanopartikeln unter Lasereinstrahlung verursacht wird, kann die Empfindlichkeit immunchromatographischer Assays (siehe Bild) verbessern. Ein zugelassener Assay für ein Kryptokokken-Antigen (violette Rauten) konnte 32-fach empfindlicher gestaltet werden. Durch Optimierung des Trägermaterials und der Eigenschaften der mit Antikörpern (blaue Y) bedeckten Nanopartikel (rote Kreise) sind weitere Verbesserungen möglich. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.