gebhart/patrepeval huggingface dataset:
Marinobufagenin regulates permeability and gene expression of brain endothelial cells (2014)

Marinobufagenin (MBG) is a cardiotonic steroid that increases in the circulation in preeclampsia. Preeclampsia and eclampsia are associated with cerebral edema. Therefore, we examined the effects of MBG on human brain microvascular endothelial cells (HBMEC) in vitro. MBG enhanced the permeability of HBMEC monolayers at 1-, 10-, and 100-nM doses, but had no effect at 0.1 nM. Agilent Human Gene Expression microarrays were utilized in these studies. MBG treatment (10 nM for 12 h) downregulated concentrations of the soluble VEGFR transcript sFLT by 59% but did not alter those of FLTv3 mRNA (determined by quantitative PCR). When treated and control HBMEC transcriptomes were interrogated on microarrays, 1,069 genes appeared to be regulated by MBG. Quantitative RT-PCR confirmed that MBG treatment upregulated ENKUR mRNA concentrations by 57%. Its protein product interacts with calmodulin and calcium channel proteins. MBG treatment downregulated several genes whose protein products are involved in cell adhesion (ITGA2B, FERMT1, CLDN16, and TMEM207) and cell signaling (GRIN2C, SLC8A1, and ESR1). The level of downregulation ranged from 22 to 66%. Altogether, MBG actively enhanced the permeability of HBMEC monolayers while downregulating genes involved in adhesion. MBG treatment had variable effects on ENKUR, GRIN2C, and SLC8A1 genes, all associated with calcium transport. These studies provide the basis for future investigations of MBG actions in normal physiology and disease.
Clinical features and neuroimaging of PARK7‐linked parkinsonism (2003)

We recently reported linkage to chromosome 1p36 (the PARK7-locus) in a family with early-onset parkinsonism. Linkage to this locus has since been confirmed in an independent data set. We describe clinical and neuroimaging features of the 4 patients in the original PARK7-linked kindred. Age at onset of parkinsonism varied from 27 to 40 years. Clinical progression was slow, and response to dopaminergic therapy good. The clinical spectrum ranged from mild hypokinesia and rigidity, to severe parkinsonism with levodopa-induced dyskinesias and motor fluctuation. Three of four patients with PARK7-linked parkinsonism exhibited psychiatric disturbances. Structural neuroimaging was unremarkable, but functional imaging of the brain, carried out in 3 patients, showed significant evidence for a presynaptic dopamine deficit, and assessment of cerebral glucose metabolism, as carried out in 1 patient, showed possible cerebellar involvement.
Residual Stress Evaluation of Hydroxyapatite Coating Ti Implant. (1997)

Bio-active ceramics which have the capability for bonding to bone have been developed as one of the most effective implant materials. Because these materials consist of brittle hydroxyapatite, their mechanical reliability and workability are much lower than those of metal. Therefore, hydroxyapatite ceramics are used as coating materials. During or after the coating process, cracking and tearing often occur in the coating layer of the implant. These defects are caused by the residual stress in the vicinity of the coating interface. It is important to evaluate the residual stress in this region. The purpose of work is to present a method for measuring simultaneously and nondestructively three-dimensional distribution of residual stress in both the hydroxyapatite coating layer and the titanium substrate, using polychromatic X-rays. From this method, the steep stress gradient in the coating layer and the increase in tensile residual stress on the surface of the substrate were confirmed.
Fig S5 from <i>Frizzled-7</i> Is Required for Wnt Signaling in Gastric Tumors with and Without <i>Apc</i> Mutations (2023)

&lt;p&gt;Figure S5. Frequency of WNT pathway mutations in gastric cancer patients (TCGA).&lt;/p&gt;
Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites (2010)

Taken together, these findings suggest that resveratrol, by acting on specific polyphenol binding sites in epidermis, may be useful to prevent skin disorders associated with aging.
The development of food allergy after liver transplantation (2005)

The acquisition of new food allergy after orthotopic liver transplantation is now a well described phenomenon, mainly reported in children. The etiology of this phenomenon is at present unclear, but has been ascribed by some to tacrolimus treatment. Here we report a case of liver transplant acquired food allergy (LTAFA) in a child who received a split liver graft. The case is remarkable for the absence of new food allergy in the adult recipient of the same graft. This suggests that host-specific factors play an important role in the development of food allergy after liver transplantation, and emphasizes the predisposition that children have toward this phenomenon. Possible mechanisms underlying the development of food allergy after liver transplantation are discussed. In conclusion, tacrolimus treatment alone cannot account for LTAFA. Host factors such as the maturity of immune regulatory mechanisms are likely to play a critical role in the development of new food allergy after a liver transplant.
Near-equilibrium growth from borophene edges on silver (2019)

Two-dimensional boron, borophene, was realized in recent experiments but still lacks an adequate growth theory for guiding its controlled synthesis. Combining ab initio calculations and experimental characterization, we study edges and growth kinetics of borophene on Ag(111). In equilibrium, the borophene edges are distinctly reconstructed with exceptionally low energies, in contrast to those of other two-dimensional materials. Away from equilibrium, sequential docking of boron feeding species to the reconstructed edges tends to extend the given lattice out of numerous polymorphic structures. Furthermore, each edge can grow via multiple energy pathways of atomic row assembly due to variable boron-boron coordination. These pathways reveal different degrees of anisotropic growth kinetics, shaping borophene into diverse elongated hexagonal islands in agreement with experimental observations in terms of morphology as well as edge orientation and periodicity. These results further suggest that ultrathin borophene ribbons can be grown at low temperature and low boron chemical potential.
Automated design of switched-current filters (1996)

This paper describes the automated design and synthesis of switched-current (SI) filters using SCADS, a flexible CAD system integrated in a major VLSI design suite. With this system, the nonspecialist can produce high performance analog filters suitable for mixed signal CMOS IC's fabricated using only standard digital processes. To achieve high levels of performance on silicon, filter designs are realized using an enhanced differential circuit technique (S/sup 2/I) in its integrators and sample-and-hold cells. The design system is described in terms of the embedded circuits, its integrated tool set, the filter design flow and the engineering procedures for ensuring reliable circuit operation. Examples of high performance video frequency filters are presented, each generated automatically by SCADS within one day. Fabricated in a 0.8 /spl mu/m standard CMOS process, they demonstrate state-of-the-art performance.
2019 Optical Materials Express Emerging Researcher Best Paper Prize: editorial (2020)

Optical Materials Express Editor-in-Chief, Alexandra Boltasseva, and Deputy Editor, Juejun Hu, announce the recipient of the 2019 prize for the best paper published by an emerging researcher in the Journal.
Proposal of quantitative analysis method concerning rotational motion of lower limb joints including joint moments as well as joint angles (2016)

In human gait motion analysis, which is one useful method for efficient physical rehabilitation to define various quantitative evaluation indices, joint angles and joint loads are measured during gait. Recently, it is thought that trans-femoral amputees with the prosthetic limb must regain motion pattern by refined rehabilitation program using joint moments as a representative joint loads and understanding them is indispensable for biomechanical consideration. On the other hand, human keeps a high correlation among the motion of all joints during gait. Joint motion analysis of the correlation extracts a few simultaneously activating segmental coordination patterns, and the structure of the intersegmental coordination is attracting attention to an expected relationship with a control strategy. However, when the evaluation method using singular value decomposition has been applied to only joint angles of the lower limb, joint moments related to the rotational motion of the joints have not yet been considered. In this paper, a novel quantitative analysis method concerning rotational motion of lower limb joints by using joint moments as well as joint angles aims to be proposed. Each parameter of the healthy subject and trans-femoral amputee is measured by using mobile force plate and attitude sensor, split-belt treadmill simultaneously and their motion patterns are analyzed by the proposed method. As a result of the experiments, patterns of each evaluation index are obtained as the remarkably different feature quantities between healthy subject and trans-femoral amputee especially pertaining to joint moments. Finally, the effectiveness of the quantitative analysis concerning human motion is validated.
A hybrid‐ARQ system using rate‐compatible trellis codes designed for rayleigh fading (1998)

Abstract This paper presents classes of rate‐compatible trellis codes designed for channels with flat, slow Rayleigh fading. The codes are “multiple” TCM (MTCM) codes as proposed by Divsalar and Simon – i.e., codes in which multiple symbols are associated with each transition through the trellis; by applying appropriate puncturing tables to low‐rate MTCM codes we obtain families of MTCM codes, all of which can be decoded with (essentially) the same decoder. By means of computer search, several such families are obtained so that each family member is at least as good as any comparable code in the literature. (“Good” here is defined in terms of minimum time diversity and minimum squared product distance, the most important parameters for performance over Rayleigh fading channels). A protocol to implement these rate‐compatible trellis codes in a type‐II hybrid ARQ format is described. The proposed protocol selectively punctures symbols from the low‐rate code based on the observed fading values observed on each branch. Upper bounds on the resulting bit error rate are developed and the results are used to select the best adaptive code from several possibilities. Simulation results comparing the proposed scheme with fixed‐rate codes of the same throughput show substantial coding gain. Finally a protocol modification limiting the variability of the code rate over a frame is described; this modification eliminates the need for excessive buffering, with a very small effect on performance.
Factors Affecting Texture Memory Appearing through &alpha;&rarr;&gamma;&rarr;&alpha; Transformation in IF Steels (2007)

In case where IF steel is heat treated in γ region, α→γ and γ→α transformation during heating and cooling, i.e. α→γ→α transformation, take place during heating and cooling, respectively. The initial texture of α is potentially weakened due to two times transformation in general. On the contrary, the α→γ→α transformed texture resembles the initial texture clearly under specific circumstances. Authors call this phenomenon “texture memory”. A very distinct texture memory effect was found in IF steels. Lowering the γ→α transformation temperature pronounces texture memory significantly. The variant selection at grain boundary of γ seems to play an important role. Moreover, it is considered that the initial α texture has to be sharp to in order to realize texture memory.
Exhaust Gas Recirculation Performance in Dry Low Emissions Combustors (2011)

In a carbon constrained world there is a need for capturing and sequestering CO2. Post-combustion carbon capture via Exhaust Gas Recirculation (EGR) is considered a feasible means of reducing emission of CO2 from power plants. Exhaust Gas Recirculation is an enabling technology for increasing the CO2 concentration within the gas turbine cycle and allow the decrease of the size of the separation plant, which in turn will enable a significant reduction in CO2 capture cost. This paper describes the experimental work performed to better understand the risks of utilizing EGR in combustors employing dry low emissions (DLE) technologies. A rig was built for exploring the capability of premixers to operate in low O2 environment, and a series of experiments in a visually accessible test rig was performed at representative aeroderivative gas turbine pressures and temperatures. Experimental results include the effect of applying EGR on operability, efficiency and emissions performance under conditions of up to 40% EGR. Findings confirm the viability of EGR for enhanced CO2 capture; In addition, we confirm benefits of NOx reduction while complying with CO emissions in DLE combustors under low oxygen content oxidizer.
An H5N1 highly pathogenic avian influenza virus isolated from a local tree sparrow in Indonesia (2011)

The isolation of an H5N1 influenza A virus from a tree sparrow (Passer montanus) captured in East Java, Indonesia in 2010 is reported here. Its hemagglutinin and neuraminidase were genetically similar to those of human isolates from 2006-2007 in Indonesia. The finding of a tree sparrow H5N1 virus that possesses genetically similar surface molecules to those of human viruses highlights the importance of monitoring resident wild birds, as well as migratory birds, for pandemic preparedness.
Aire deficiency causes enhanced endogenous superantigen-mediated TCR revision (2006)

Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. In these studies we have investigated the peripheral tolerance mechanisms controlled by the autoimmune regulator (Aire) gene in Aire deficient mice, an animal model of the monogenic disease autoimmune polyendocrine syndrome type I (APS I).Aire-/- mice displayed increased numbers of myeloid-derived antigen-presenting cells (APCs) in the spleen, lymph nodes and peritoneum as well as more blood monocytes and metallophilic macrophages in the spleen. Monocytes were also increased in the blood of APS I patients. Monocyte precursors displayed an accelerated development in the bone marrow of Aire-/- mice, and Aire-/- APCs had an altered phenotype that caused an increased immune response in several different contexts. Aire-/- splenic and lymph node dendritic cells had an increased ability to activate naive T cells, partly as a result of an upregulated expression of the costimulatory molecule VCAM-1. In Aire-/- mice increased activity of the metallophilic macrophages in the splenic marginal zone seems to be responsible both for the activated phenotype of marginal zone B cells and for the frequent development of marginal zone lymphoma with aging. In a TCR transgenic model Aire deficiency caused an increased superantigen-mediated TCR revision in the spleen, perhaps as a result of the altered phenotype of APCs in the spleen. Finally, Aire was shown to influence autoimmune disease development by a macrophage-dependent mechanism in diabetes induced with multiple low dose streptozotocin injections.These results indicate that Aire has an important function in peripheral tolerance by controlling the phenotype of myeloid-derived APCs and thereby regulating the activation of T and B lymphocytes.
Spontaneous copolymerization of 1,3‐cycloheptadiene with acrylonitrile in the presence of zinc chloride (1981)

Abstract The reaction of 1,3‐cycloheptadiene (1,3‐CHpD) with acrylonitrile (AN) in the presence of ZnCl 2 leads spontaneously to the simultaneous formation of an alternating copolymer and a small amount of cycloadduct. The copolymer has a predominantly cis ‐1,4‐structure. The formation of the charge—transfer complex between 1,3‐CHpD and (AN)c (AN coordinated to ZnCl 2 ) in AN was detected by ultraviolet (UV) spectroscopy. The activation energies for the cycloaddition and for the copolymerization under the conditions used were determined to be 17.6 (in the presence of 1,1‐diphenyl‐2‐picrylhydrazyl) and 16.3 kcal/mole, respectively. The rate of copolymerization in AN was found to depend on the 1.5th power of the concentrations of (AN)c and of 1,3‐CHpD. Oxygen and UV irradiation causes an acceleration of the copolymerization only. On the basis of these results the mechanism of the spontaneous copolymerization is discussed and its relation to the cycloaddition in systems of 1,3‐cyclodienes and AN in the presence of ZnCl 2 is mentioned.
Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses (2016)

The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation.
Handbook of Bolts and Bolted Joints (1998)

MATERIAL PROPERTIES AND SELECTION Fastener Materials, A.C. Hood Joining with Aluminum Alloy Bolts and Nuts, R.E. Mack Thread Lubricants, G. Novak and T. Patel Adhesives and Sealants for Bolting, J. Cocco PROCESSING OF FASTENERS Fastener Manufacturing, J.A. Phebu and P.K. Kasp Fastener Coatings, J. Laurillard Fastener Quality, C.B. Wackrow THREADED FASTENERS Screw Threads, E. Schwartz and J.H. Bickford Fasteners Head Markings, C. Wilson Computing the Strength of a Fastener, J. Barron Computing the Stiffness of a Fastener, J. Barron Metric Fasteners, B. Marbacher Washers: A Guide to Their Function and Selection, M. Levinson Belleville Springs, G. Davet Vibration-Resistant Fasteners, J.R. Dudley Concrete Anchors, R.L. Zink Aerospace Bolts, S. Sadri DESIGN AND ANALYSIS OF BOLTED JOINTS VDI Joint Design Procedures, A.W. Heston Design of Gasketed Joints, B.S. Nau ASME Boiler and Pressure Vessel Code Design Rules for Bolted Flanges, G. Bibel Design of Joints Loaded in Shear, R.T. Barrett Design Rules for Structural Steel Bolting, J.H. Bickford and W.A. Milek ASSEMBLY OF BOLTED JOINTS Behavior of a Bolted Joint During Assembly, J.H. Bickford Tightening Groups of Fasteners in a Structure and the Resulting Elastic Interaction, G. Bibel Hydraulically Powered Wrenches, G. Sturdevant Hydraulic Stud Tensioning, W. Biach The Multi-Jackbolt Tensioning System, R.H. Steinbock Selecting Fastening Strategies and Equipment for Mass Production, J.R. Bippus Torque Control of Assembly, J.H. Bickford Stretch Control, R. Corbett Increasing Joint Performance by Tightening Bolts to Yield, P.W. Wallace Torque-Angle-Tension Control, R.S. Shoberg Control with Direct Tension Indicators, D. Sharp Use of Ultrasonics in Bolted Joints, S. Nassar Selecting Preload for an Existing Joint, J. H. Bickford THE JOINT IN SERVICE Joint Diagrams, J.H. Bickford Bolt Fatigue, F.R. Kull Corrosion, K.E. Yee The Susceptibility of Fasteners to Hydrogen Embrittlement and Stress Corrosion Cracking, L. Raymond Vibration-and Shock-Induced Loosening, D. Hess TESTING AND INSPECTION OF BOLTS AND JOINTS Statistical Design and Analysis of Multivariable Experiments, B. Clement Field Testing of Structural Bolts and Installation Tools Using a Bolt Tension Calibrator, J. Wilhelm Torque-Tension Audits, R. Shoberg EDUCATION AND TRAINING Fastening Technology Education, B. Blendu
Frequency-domain adaptive multidelay algorithm with sparseness control for acoustic echo cancellation (2009)

A frequency-domain adaptive algorithm for acoustic echo cancellation is proposed. This new algorithm dynamically adjusts its step-size according to the sparseness variation in acoustic impulse responses that arise in a mobile environment. Inheriting the beneficial properties of both the fast convergence of the improved proportionate normalized least mean squares (IPNLMS) and the efficient implementation of the multidelay filtering (MDF) algorithm, the proposed sparseness-controlled improved proportionate MDF (SC-IPMDF) algorithm is evaluated using white Gaussian noise (WGN) and speech input signals with acoustic impulse responses of various degrees of sparseness. Simulation results show an improved performance over the MDF and improved proportionate MDF (IPMDF) algorithms with only a modest increase in computational complexity. 1.
Mapping the potential of graphite nanotubes with electron holography (1996)

The technique of transmission electron holography has been employed to investigate the nanoscale features of graphitic nanotubes (buckytubes) and their particulate derivatives. Reconstructed phase images of holograms offer a quantitative means to calculate the mean inner potential (MIP), thickness profiles, and three-dimensional morphology for multi-/single shell buckytubes, their ‘‘tips’’ and other enclosed structures. It is demonstrated that electron holography is also sensitive to the defect nature of termination and bending in buckytubes and their particulate derivatives. Phase sensitivity of about 0.1 rad is demonstrated for single-layer buckytube, which corresponds to change in phase due to two monolayers of carbon.
Preparation and Characterization of Ag2E (E = Se, Te) Using the Sonochemically Assisted Polyol Method (2002)

Nanocrystals of Ag2E (E = Se, Te) were prepared using the polyol reduction method under sonochemical irradiation. Particles were characterized using TEM, HRTEM, SEM, and XRD. The optical properties of the products were studied using photoacoustic spectroscopy (PAS). The differences between the as-prepared samples and single crystals and method of the nanoparticle formation are discussed.
Cationic reactivation polymerization of vinyl monomers (1988)

Abstract The oationio polymerization of strong π‐donor monomers has been investigated, where initiation takes place with triphenylmethylium picrate and picric acid, respectively. In the case of p‐methoxystyrene the polymerization runs via aggregated species, where monomer and picric acid stabilizes the propagating intermediate state. The transfer‐suppressed polymerization oan be reactivated after monomer consumption. The mechanism of IBVE polymerization runs similar, however, by side reactions double bonds can be introduced into the polymer chains and chains can be terminated by water under formation of aldehyde groups. NVC polymerization proceeds via freely solvated ions, which results in relative broad MWD. The polymerization of NVC and p‐methoxystyrene initiated with cationogenes involving nucleophilic counterions, leads in the presence of AEROSIL to increased molecular weights and narrow distribution, in comparison with the polymerization under same conditions in solution.