gebhart/patrepeval huggingface dataset:
Abstract LB-227: Preclinical pharmacology and clinical efficacy of AZD9150 (ISIS-STAT3Rx), a potent next-generation antisense oligonucleotide inhibitor of STAT3 (2014)

Abstract Genomic technologies have greatly expanded our understanding of cancer biology, although they have not yet been effectively translated into improved cancer therapeutics, partly due to the inability of available therapeutic modalities to target the most promising cancer driver pathways. In contrast to other therapeutic approaches, antisense technology allows the rational design of potent, sequence-specific inhibitors based on genome sequencing information alone. Recent human clinical data have demonstrated the potent activity of antisense oligonucleotides (ASOs) targeted to genes expressed by the liver. Here we describe preclinical and clinical activity of a high affinity, new generation chemistry (constrained ethyl modified) ASO, AZD9150. AZD9150 targets the mRNA coding for the transcription factor STAT3, which is considered a difficult protein to target therapeutically. Systemic delivery of unformulated AZD9150 resulted in strong inhibition of STA3 RNA and protein levels in demonstrates in a broad range of preclinical cancer models in vivo including several patient-derived xenograft models. AZD9150 administration resulted in 2 partial responses highly treatment-refractory diffuse large B-cell lymphoma and in 2 mixed responses in Hodgkin's Lymphoma patients in the phase I dose escalation study. These findings suggest that this technology has the potential to help bridge the pharmacogenomic divide in cancer drug discovery. [D.H. and Y.K. contributed equally to this work.] Citation Format: David Hong, Youngsoo Kim, Anas Younes, John Nemunaitis, Nathan Fowler, Jeff Hsu, Tianyuan Zhou, Luis Fayad, Nancy Zhang, Sarina Piha-Paul, Richard Woessner, Murali VP Nadella, Deborah Lawson, Corinne Reimer, Minji Jo, Joanna Schmidt, Xiaokun Xiao, Sarah Greenlee, Gene Hung, Mason Yamashita, David C. Blakey, Brett P. Monia, A. Robert Macleod, Razelle Kurzrock. Preclinical pharmacology and clinical efficacy of AZD9150 (ISIS-STAT3Rx), a potent next-generation antisense oligonucleotide inhibitor of STAT3. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-227. doi:10.1158/1538-7445.AM2014-LB-227
Value-Added Metrology (2007)

The conventional premise, long-touted among the semiconductor processing community, that metrology is a ldquonon-value-added necessary evil,rdquo is a misleading and dangerous assertion, which must be viewed as obsolete thinking. Many metrology applications are key enablers to traditionally labeled ldquovalue-addedrdquo processing steps in lithography and etch, such that they can be considered integral parts of the processes. Various key trends in modern, state-of-the-art processing such as optical proximity correction, design for manufacturability, and advanced process control are based, at their hearts, on the assumption of fine-tuned metrology, in terms of uncertainty and accuracy. These trends are vehicles where metrology thus has large opportunities to create value through the engineering of tight and targetable process distributions. Such distributions make possible predictability in speed-sorts and in other parameters, which results in a high-end product. Additionally, significant reliance has also been placed on defect metrology to predict, improve, and reduce yield variability. The necessary quality metrology is strongly influenced by not only the choice of equipment, but also the quality application of these tools in a production environment. The ultimate value added by metrology is a result of quality tools run by a quality metrology team using quality practices. This paper will explore the relationships among present and future trends and challenges in metrology, including equipment, key applications, and metrology deployment in the manufacturing flow. Of key importance are metrology personnel, with their expertise, practices, and metrics in achieving and maintaining the required level of metrology performance, including where precision, matching, and accuracy fit into these considerations. The value of metrology will be demonstrated to have shifted to being a ldquokey enabler of large revenues,rdquo debunking the out-of-date premise that metrology is ldquonon-value-added.rdquo
Large Voltage-Induced Coercivity Change in Pt/Co/CoO/Amorphous TiOx Structure and Heavy Metal Insertion Effect (2021)

Abstract There is urgent need for spintronics materials exhibiting a large voltage modulation effect to fulfill the great demand for high-speed, low-power-consumption information processing systems. Fcc-Co (111)-based systems are a promising option for research on the voltage effect, on account of their large perpendicular magnetic anisotropy (PMA) and high degree of freedom in structure. Aiming to observe a large voltage effect in a fcc-Co (111)-based system at room temperature, we investigated the voltage-induced coercivity ( H c ) change of a perpendicularly magnetized Pt/heavy metal/Co/CoO/amorphous TiO x structure. The thin CoO layer in the structure was the result of the surface oxidation of Co. We observed a large voltage-induced H c change of 20.2 mT by applying 2 V (0.32 V/nm) to a sample without heavy metal insertion, and an H c change of 15.4 mT by applying 1.8 V (0.29 V/nm) to an Ir-inserted sample. The relative thick Co thickness, Co surface oxidation, and large dielectric constant of TiO x layer could be related to the large voltage-induced H c change. Furthermore, we demonstrated the separate adjustment of H c and a voltage-induced H c change by utilizing both upper and lower interfaces of Co.
Phase separation in t-J ladders (1999)

The phase separation boundary of isotropic t-J ladders is analyzed using density matrix renormalization group techniques. The complete boundary to phase separation as a function of J/t and doping is determined for a chain and for ladders with two, three and four legs. Six-chain ladders have been analyzed at low hole doping. We use a direct approach in which the phase separation boundary is determined by measuring the hole density in the part of the system which contains both electrons and holes. In addition we examine the binding energy of multi-hole clusters. An extrapolation in the number of legs suggests that the lowest J/t for phase separation to occur in the two dimensional t-J model is J/t~1.
Non-iterative Comprehensive Normalisation (2002)

The light reflected from an object depends not only on object colours but also on lighting geometry and illuminant colour. As a consequence the raw colour recorded by a camera is not a reliable cue for object based tasks such as recognition and tracking. One solution to this problem is to find functions of image colours that cancel out dependencies due to illumination. While many invariant functions cancel out either dependency due to geometry or dependency due to illuminant colour, only the comprehensive normalisation has been shown (theoretically and experimentally) to cancel both. However, this invariance is bought at the price of an iterative procedure.In this paper we develop a non iterative log comprehensive normalisation procedure. We begin by reviewing the idea that lighting effects due to geometry and light colour can, under certain reasonable simplifying assumptions, both be modelled using simple scalar multipliers. We nowtake logarithms and turn geometry and light colour dependency into additive processes. We show how in this log color space two simple projection operators lead to invariance to geometry and light colour. Moreover, because projection operators are idempotent, illuminant invariance is achieved in a single step. Experiments demonstrated that log comprehensive normalisation used as a preprocessing step supports accurate colour based object recognition independent of lighting conditions.
Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview (2017)

Team sport athletes face a variety of nutritional challenges related to recovery during the competitive season. The purpose of this article is to review nutrition strategies related to muscle regeneration, glycogen restoration, fatigue, physical and immune health, and preparation for subsequent training bouts and competitions. Given the limited opportunities to recover between training bouts and games throughout the competitive season, athletes must be deliberate in their recovery strategy. Foundational components of recovery related to protein, carbohydrates, and fluid have been extensively reviewed and accepted. Micronutrients and supplements that may be efficacious for promoting recovery include vitamin D, omega-3 polyunsaturated fatty acids, creatine, collagen/vitamin C, and antioxidants. Curcumin and bromelain may also provide a recovery benefit during the competitive season but future research is warranted prior to incorporating supplemental dosages into the athlete's diet. Air travel poses nutritional challenges related to nutrient timing and quality. Incorporating strategies to consume efficacious micronutrients and ingredients is necessary to support athlete recovery in season.
Millions of microplastics released from a biodegradable polymer during biodegradation/enzymatic hydrolysis (2022)

In this article, we show that enzymatic hydrolysis of a biodegradable polyester (poly(ε-caprolactone)) by Amano Lipase PS in an aqueous (buffer) environment yielded rapidly an excessive number of microplastic particles; merely 0.1 g of poly(ε-caprolactone) film was demonstrated to yield millions of particles. There were also indications of non-enzymatic hydrolysis at the same conditions, but this did not yield any particles within the time frame of the experiment (up to 6 days). Microplastic particles formed had irregular shapes with an average size of around 10 µm, with only a few reaching 60 µm. The formation of microplastic particles resulted from the uneven hydrolysis/erosion rate across the polymer film surface, which led to a rough and undulating surface with ridge, branch, and rod-shaped micro-protruding structures. The consequent detachment and fragmentation of these micro-sized protruding structures resulted in the release of microplastics to the surroundings. Together with microplastics, hydrolysis products such as acidic monomers and oligomers were also released during the enzymatic hydrolysis process, causing a pH decrease in the surrounding liquid. The results suggest that the risk of microplastic pollution from biodegradable plastics is notable despite their biodegradation. Special attention needs to be paid when using and disposing of biodegradable plastics, considering the enormous impact of the paradigm shift towards more biodegradable products on the environment.
Baculovirus as vector : expression of pseudorabies virus gp50 (1990)

*URD-INRA, 2 Place Viala, 34060 Montpellier Cedex 01 (FRA) Diffusion du document : URD-INRA, 2 Place Viala, 34060 Montpellier Cedex 01 (FRA)
Measurement of prompt D$^{0}$, $\Lambda_{c}^{+}$, and $\Sigma_{c}^{0,++}$(2455) production in pp collisions at $\sqrt{s} = 13$ TeV (2021)

The $p_{\rm T}$-differential production cross sections of prompt D$^{0}$, $\Lambda_{\rm c}^{+}$, and $\Sigma_{\rm c}^{0,++}(2455)$ charmed hadrons are measured at midrapidity ($|y| < 0.5$) in pp collisions at $\sqrt{s} = 13$ TeV. This is the first measurement of $\Sigma_{\rm c}^{0,++}$ production in hadronic collisions. Assuming the same production yield for the three $\Sigma_{\rm c}^{0,+,++}$ isospin states, the baryon-to-meson cross-section ratios $\Sigma_{\rm c}^{0,+,++}/{\rm D}^{0}$ and $\Lambda_{\rm c}^{+}/{\rm D}^{0}$ are calculated in the transverse momentum ($p_{\rm T}$) intervals $2 < p_{\rm T} < 12$ GeV/$c$ and $1 < p_{\rm T} < 24$ GeV/$c$. Values significantly larger than in e$^{+}$e$^{-}$ collisions are observed, indicating for the first time that baryon enhancement in hadronic collisions also extends to the $\Sigma_{\rm c}$. The feed-down contribution to $\Lambda_{\rm c}^{+}$ production from $\Sigma_{\rm c}^{0,+,++}$ is also reported and is found to be larger than in e$^{+}$e$^{-}$ collisions. The data are compared with predictions from event generators and other phenomenological models, providing a sensitive test of the different charm-hadronisation mechanisms implemented in the models.
Few-mode erbium-doped fiber laser using saturable absorber (1996)

Summary form only given. In summary, a long Fabry-Perot Er-doped fiber laser with a few modes was demonstrated by using the combination of a saturable absorber and the position control of the gain medium. We believe that the mode selection method we describe here can provide useful light sources for many optical systems.
Evaluation of radiation dose reduction via myocardial frame reduction in dynamic cardiac CT for perfusion quantitation (2018)

Dynamic contrast enhanced cardiac CT acquisitions can quantify myocardial blood flow (MBF) in absolute units (ml/min/g), but repeated scans increase X-ray radiation dose to the patient. We propose a novel approach using high temporal sampling of the input function with reduced temporal sampling of the myocardial tissue response. This type of data could be acquired with current bolus tracking acquisitions or with new acquisition sequences offering reduced radiation dose and potentially easier data processing and flow estimation. To evaluate this type of data, we prospectively acquired a full dynamic series [12 -18 frames (mean 14.5&plusmn;1.4) over 23 to 44 seconds (mean 31.3&plusmn;5.0 sec)] on 28 patients at rest and stress (N=56 studies) and examined the relative performance of myocardial perfusion estimation when the myocardial data is subsampled down to 8, 4, 2 or 1 frame(s). Unlike previous studies, for all frame rates, we consider a well-sampled input function. As expected, subsampling linearly reduces radiation dose while progressively decreasing estimation accuracy, with the typical absolute error in MBF (as compared to the full-length series) increasing from 0.22 to 0.30 to 0.35 to 1.12 ml/min/g as the number of frames used for estimation decreases from 8 to 4 to 2 to 1, respectively. These results suggest that high temporal sampling of the input function with low temporal sampling of the myocardial response can provide much of the benefit of dynamic CT for MBF quantification with dramatic reductions in the required number of myocardial acquisitions and the associated radiation dose (e.g. 77% dose reduction for 2-frame case).
Follow up of serial urea breath test results in patients after consumption of antibiotics for non-gastric infections (2002)

Our results suggested that one-third of H. pylori-infected individuals had transient false-negative urea breath test results during treatment with antibacterial agent. However, clearance of H. pylori infection by regular antibiotic consumption is rare.
Properties that change as superconductivity disappears at high-doping concentrations inLa2−xSrxCuO4 (1989)

In the system ${\mathrm{La}}_{2\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Sr}}_{\mathrm{x}}$${\mathrm{CuO}}_{4}$, as x and p (the [${\mathrm{CuO}}_{2}$${]}^{\mathrm{p}\mathrm{\ensuremath{-}}2}$ charge) are increased, the superconducting transition temperature first increases, then peaks becoming nonsuperconducting for x\ensuremath{\gtrsim}0.26. We report here a search for changes in physical properties at the values of x where ${T}_{c}$ is observed to change its behavior. The in-plane lattice constants and the normal resistivity both show a continued monotonic decrease over this entire region, suggesting that no major electronic changes occur. The tetragonal-to-orthorhombic transition temperature ${T}_{s}$ also decreases with increasing x and becomes unobservable for x\ensuremath{\gtrsim}0.19, suggesting that this structural transition itself is unrelated to the disappearance of superconductivity that occurs at higher doping levels. The magnetic spin susceptibility ${\ensuremath{\chi}}_{\mathrm{spin}(\mathrm{T}}$) generally rises gradually with increasing doping (reflecting decreasing spin-spin interactions), reaches a maximum near x\ensuremath{\sim}0.25, and then decreases. There is a weak peak in ${\ensuremath{\chi}}_{\mathrm{spin}(\mathrm{T}}$) as a function of temperature at T=${T}_{\mathrm{max}}$. As a function of increasing x,${T}_{\mathrm{max}}$ falls to zero near x\ensuremath{\sim}0.25. These two observations might be related to the disappearance of superconductivity, since all three occur near the same value of Sr content x.
Wafer Backside Cleaning Strategies for High-k/Metal Gate Processing (2005)

In this work the removal of different metallic and particulate contaminants relevant for high-k/metal gate processing is studied. Best cleaning efficiency of both silicon and nitride substrates is achieved using a HF/HNO3-based cleaning resulting in a particle removal efficiency higher than 90% and metal removal down to 1010 at/cm2.
Development and Calibration of a Two-Dye Fluorescence System for Use in Two-Phase Micro Flow Thermometry (2006)

The increasing need for more effective cooling in electronic devices has led to research into the use and modeling of two-phase cooling strategies in micro-scale geometries. In order to verify these models it is necessary to reliably determine local parameters such as fluid temperature in boiling flows, which cannot be easily obtained due to micro-scale geometries. A convenient and non-contact method of thermometry is the use of fluorescence where the emitted intensity is a function of the local temperature. Previous work has verified the ability to use single dyes to measure void fraction in isothermal cases and suggested the possibility of simultaneous thermometry using a system of two dyes. In the present work, we verify the ability to measure the temperature of a single-phase liquid system using pairs of dyes and to this end also determine if two-dye temperature-intensity calibration curves could be accurately constructed from single dye calibration curves. The experimental set-up and procedure yield calibration results from 300K to 400K for Stilbene 420, Kiton Red, Rhodamine B and Fluorescein. Two-dye calibration curves are constructed from single-dye calibration curves and compared experimentally to a system containing two dyes in mixture. The small variation in predicted and actual responses suggest that two-dye systems should be calibrated in mixture form, and if done accurately, have the potential to measure the liquid temperature of a two-phase system
Information analysis technology for Universal Communication (2010)

The Internet functions as a social infrastructure and stores a huge amount of information. People use the Internet whenever they need information. The primary role of the Internet is changing from that of digital content sharing to that of knowledge sharing. NICT Knowledge Clustered Group is researching and developing information analysis technology for “Universal Communication”. In order to realize universal communications, we have to overcome several barriers. Information analysis is an essential technology to overcome a barrier of “Information Quality”. The overabundance that makes it difficult to extract the most useful information from the Internet is called the information explosion. The amount of consumer generating media (CGM) is increasing particularly rapidly, but the content may be neither valuable nor trusted. Ordinary web search engines cannot evaluate the content. However, if we can evaluate the credibility of information, credible digital content will be as easily accessed knowledge is on the Internet. We believe that information analysis technology to find higher quality information on Web content enables us to overcome a barrier of “Information Quality”.Research project of NICT Knowledge Clustered Group focuses on analysis of information credibility criteria and development of a knowledge cluster system. The former project addresses the information credibility criteria of web content using natural language processing (NLP) technology. The latter project aims to develop a knowledge cluster system that manages knowledge on enormous numbers of sites.
HCI reliability control in HV-PMOS transistors: Conventional EDMOS vs. Dielectric RESURF and lateral field plates (2009)

This paper demonstrates that degradation mechanisms can be controlled by electric field tuning with Dielectric RESURF (STI -Shallow Trench Isolation- interleaves in the drain extension) and lateral field plates (gate fingers on top of the STI regions). Transistors, rated for max. V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</inf> =5.5 and 20 V, show on-resistance (R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> ) of 6.5 and 40 mΩmm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> respectively (comparable with optimized devices [1, 2]) and 10 years Hot Carrier Injection (HCI) lifetime in 65 nm CMOS technology.
An Evaluation Of Stereo Speech Enhancement Methods For Different Audio-Visual Scenarios (2015)

Publication in the conference proceedings of EUSIPCO, Nice, France, 2015
Figure S3 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Figure 3: Association of chemokine expression with a T cell-inflamed phenotype was validated in a second independent PDAC patient cohort&lt;/p&gt;
Synthesis of 2,3-Dimethylbutenes by Dimerization of Propene Using Highly Active Nickel-Phosphine Catalysts in the Presence of Sulfonic Acids and/or Dialkyl Sulfates (1997)

Abstract A nickel-phosphine catalyst system consisting of nickel naphthenate, P(cyclo-C6H11)3, AlEt3, and 2,4,6-trichlorophenol (TCP) in the presence of sulfonic acids (CF3SO3H and MeSO3H) or dialkyl sulfates (Me2SO4 and Et2SO4) exhibits remarkable catalytic activity for the dimerization of propene. The catalytic activity (turnover number (TON) for the formation of C6 olefins or 2,3-dimethylbutenes) was enhanced when the catalyst was combined with effective additives, such as Et2SO4 and MeSO3H. The reaction products consisted of 2,3-dimethyl-1-butene (DMB-1) and/or 2,3-dimethyl-2-butene (DMB-2) in high yields (selectivity of dimers based on the reacted propene = 70—80%: selectivity of 2,3-dimethylbutenes in C6 olefins = 78—80%). The ratio of DMB-1/DMB-2 could be controlled by varying the molar ratios of the catalyst ingredients without decreasing in the turnover numbers. Although CF3SO3H was found to be the best additive as far as the catalytic activity and the selectivity of dimers (94—99%) are concerned, the selectivity of 2,3-dimethylbutenes in C6 olefins decreased. The addition of a small amount of water was also effective to enhance the catalytic activity: The turnover number for the formation of 2,3-dimethylbutenes was raised from 7050 to 30360.
Systematic corrections to Flory–Huggins theory: Polymer–solvent–void systems and binary blend–void systems (1988)

A field theory, presented earlier by us, which is formally an exact mathematical solution of the Flory–Huggins lattice model, is used to evaluate corrections to Flory–Huggins mean field theory in a systematic series expansion in the inverse of the lattice coordination number and in the nearest-neighbor interaction energies. We explicitly determine the first few corrections to the free energy of mixing for polymer–solvent–void systems and for systems containing two kinds of polymers and voids (binary blend–void systems). Applications of the theory to the calculation of equations of state and effective Flory χ parameters are discussed. We compare the result of our theory with the lattice Monte Carlo data of Dickman and Hall for the chain insertion probability and for the pressure in a system of athermal chains and voids. Good quantitative agreement is found. We discuss shortcomings of the lattice model in representing real polymers as well as possible extensions of the model to remedy these deficiencies.