gebhart/patrepeval huggingface dataset:
Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications (2018)

The autologous, synthetic, and animal-derived grafts currently used as scaffolds for tissue replacement have limitations due to low availability, poor biocompatibility, and cost. Plant tissues have favorable characteristics that make them uniquely suited for use as scaffolds, such as high surface area, excellent water transport and retention, interconnected porosity, preexisting vascular networks, and a wide range of mechanical properties. Two successful methods of plant decellularization for tissue engineering applications are described here. The first method is based on detergent baths to remove cellular matter, which is similar to previously established methods used to clear mammalian tissues. The second is a detergent-free method adapted from a protocol that isolates leaf vasculature and involves the use of a heated bleach and salt bath to clear the leaves and stems. Both methods yield scaffolds with comparable mechanical properties and low cellular metabolic impact, thus allowing the user to select the protocol which better suits their intended application.
FTIR Studies of the Adsorption/Desorption Behavior of Cu Chemical Vapor Deposition Precursors on Silica: III . Re‐examination of (1,1,1,5,5,5‐hexafluoroacetylacetonato)(vinyltrimethylsilane)copper(I), (1994)

The reaction of with surfaces with varying surface concentrations of isolated and hydrogen‐bonded surface hydroxyl groups and four‐membered rings has been investigated. The adsorbed reacted with the hydrogen‐bonded surface hydroxyl groups and the strained siloxane sites and interacted with the isolated surface hydroxyl groups. The ligand was completely liberated from the adsorbed compound between 125 and 175°C depending on the relative ratios of the reactive surface sites. Because all surfaces have some combination of these reactive sites, dissociation of to give "" and is always expected. Selective chemical vapor deposition (CVD) relies on the slow nucleation of Cu on which involves a number of steps in series including adsorption, dissociation, and reaction to give Cu atoms and physical nucleation to give stable nuclei. This suggests that selective CVD must rely on slow adsorption, dissociation, reaction, or physical nucleation to limit the formation of Cu clusters on the nongrowth, surface. Results from this work and the literature suggest that most of these steps are slower on than on Cu surfaces. However, the rates of these steps can be increased sufficiently by increasing temperature and precursor partial pressure to result in loss of selectivity.
Parameter Estimation of Hemodynamic Cardiovascular Model for Synthesis of Photoplethysmogram Signal (2020)

Synthesis of accurate, personalize photoplethysmogram (PPG) signal is important to interpret, analyze and predict cardiovascular disease progression. Generative models like Generative Adversarial Networks (GANs) can be used for signal synthesis, however, they are difficult to map to the underlying pathophysiological conditions. Hence, we propose a PPG synthesis strategy that has been designed using a cardiovascular system, modeled through the hemodynamic principle. The modeled architecture is composed of a two-chambered heart along with the systemic-pulmonic blood circulation and a baroreflex auto-regulation mechanism to control the arterial blood pressure. The comprehensive PPG signal is synthesized from the cardiac pressure-flow dynamics. In order to tune the modeled cardiac parameters with respect to a measured PPG data, a novel feature extraction strategy has been employed along with the particle swarm optimization heuristics. Our results demonstrate that the synthesized PPG is accurately followed the morphological changes of the ground truth (GT) signal with an RMSE of 0.003 occurring due to the Coronary Artery Disease (CAD) which is caused by an obstruction in the artery.
PDL-Tolerant Signal Generation by Digital Spectrum Slicing and Polarization Control (2015)

We propose a novel PDL-tolerant signal generation and reception method without additional optical devices and numerically demonstrate its efficiency for a 128 Gbit/s 2 subcarrier Nyquist-FDM DP-QPSK signal.
Analytical SERS: general discussion (2017)

George Schatz opened a general discussion of the paper by Zhong-Qun Tian: The dependence of Raman intensities with the angle of incidence and angle of scattering is an important issue. This was described for flat surfaces long ago (before SERS) by Greenler and Schlager.1 How do your results dif
Supplementary Figure 5 from Functional Characterization of Filamin A Interacting Protein 1–Like, a Novel Candidate for Antivascular Cancer Therapy (2023)

Supplementary Figure 5 from Functional Characterization of Filamin A Interacting Protein 1–Like, a Novel Candidate for Antivascular Cancer Therapy
Data from CD137/OX40 Bispecific Antibody Induces Potent Antitumor Activity that Is Dependent on Target Coengagement (2023)

&lt;div&gt;Abstract&lt;p&gt;Following the success of immune checkpoint blockade therapy against cancer, agonistic antibodies targeting T-cell costimulatory pathways are in clinical trials. The TNF superfamily of receptors (TNFRSF) members CD137 and OX40 are costimulatory receptors that stimulate T-cell proliferation and activation upon interaction with their cognate ligands. Activating CD137 and OX40 with agonistic mAbs stimulates the immune system due to their broad expression on CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells and natural killer cells and has antitumor effects in preclinical models. Most TNFRSF agonist antibodies require crosslinking via Fcγ receptors (FcγR), which can limit their clinical activity. FS120 mAb&lt;sup&gt;2&lt;/sup&gt;, a dual agonist bispecific antibody targeting CD137 and OX40, activated both CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells in an FcγR-independent mechanism, dependent on concurrent binding. A mouse surrogate version of the bispecific antibody displayed antitumor activity in syngeneic tumor models, independent of T regulatory cell depletion and of FcγR interaction, but associated with peripheral T-cell activation and proliferation. When compared with a crosslink-independent CD137 agonist mAb, the FS120 surrogate induced lower liver T-cell infiltration. These data support initiation of clinical development of FS120, a first-in-class dual agonist bispecific antibody for the treatment of human cancer.&lt;/p&gt;&lt;/div&gt;
Organic compound alteration during hypervelocity collection of carbonaceous materials in aerogel (2009)

Abstract— The NASA Stardust mission brought to Earth micron‐size particles from the coma of comet 81P/Wild 2 using aerogel, a porous silica material, as the capture medium. A major challenge in understanding the organic inventory of the returned comet dust is identifying, unambiguously, which organic molecules are indigenous to the cometary particles, which are produced from carbon contamination in the Stardust aerogel, and which are cometary organics that have been modified by heating during the particle capture process. Here it is shown that 1) alteration of cometary organic molecules along impact tracks in aerogel is highly dependent on the original particle morphology, and 2) organic molecules on test‐shot terminal particles are mostly preserved. These conclusions are based on two‐step laser mass spectrometry (L 2 MS) examinations of test shots with organic‐laden particles (both tracks in aerogel and the terminal particles themselves).
Resilient Ultra Stable CMOS-MEMS Oscillator with Receiver in Intel 22FFL Technology (2021)

A frequency-scalable reference oscillator based on a Scandium doped Aluminum Nitride-on-silicon contour-mode micromechanical resonator is demonstrated for the first time which utilizes an oscillator receiver implemented in Intel 22FFL node. The oscillator operates at 95 MHz, with a total power consumption of 1 mW including the amplitude/bias control and the shaper circuitry (@1.2 V supply). A phase noise of -107 dBc/Hz @ 1 kHz offset and an RMS jitter of 870 fs over the frequency range of 12kHz-5MHz are measured for this oscillator. Aging is also studied over a period of 25 days with a promising frequency drift of less than 4 ppm. The temperature compensated ScAlN on silicon resonator exhibited a quality factor of 5k and maximum frequency vs temperature variation of 450 ppm over the -40 °C to 125 °C temperature range making the oscillator a viable alternative for reference crystal oscillators in computing systems.
STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells (2010)

Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how inflammatory molecules modulate PPARγ signaling in distinct subsets of cells. Proinflammatory molecules inhibited whereas interleukin-4 (IL-4) stimulated PPARγ activity in macrophages and DCs. Furthermore, IL-4 signaling augmented PPARγ activity through an interaction between PPARγ and signal transducer and activators of transcription 6 (STAT6) on promoters of PPARγ target genes, including FABP4. Thus, STAT6 acts as a facilitating factor for PPARγ by promoting DNA binding and consequently increasing the number of regulated genes and the magnitude of responses. This interaction, underpinning cell type-specific responses, represents a unique way of controlling nuclear receptor signaling by inflammatory molecules in immune cells.
Structure and transport properties of a porous magnetic gel via x-ray microtomography (1996)

A three-dimensional digitized image of a porous magnetic gel is determined by x-ray microtomographic techniques. The complex connected pore-space topology is quantitatively characterized by measuring a variety of statistical correlation functions, including the chord-length distribution function, the pore-size distribution function, and the lineal-path function. This structural information is then employed to estimate transport properties, such as the fluid permeability and trapping rate, of the gel. \textcopyright{} 1996 The American Physical Society.
Entropy-driven chemisorption of NOx on phosphotungstic acid (2014)

Nitrogen oxides (NO x ) -mostly caused by the combustion of fossil fuels-contribute to the formation of ozon, smog and acid rain, so lowering NO x emissions to the atmosphere is desired.[1] Phosphotungstic acid is a selective NO x adsorbent with high adsorption capacity that could be used to capture NO x molecules from exhaust gases and later release them for processing.[2] A variety of experimental and computational approaches -including ex-situ and in-situ X-ray diffraction, neutron diffraction, NMR and DFT calculations -determined the nature of the chemisorbed NO x species and elucidated the reaction behavior.Experiments show that at high temperature, NO x adsorption occurs, while at low temperature, the reverse reaction takes place.DFT calculations could assign this behavior to the entropy change during the reaction.Upon chemisorption of 3 NO molecules and 3 NO 2 molecules, 15 water molecules are released from the phosphotungstic acid hexahydrate (See Figure).This gives rise to a positive reaction entropy whereas the reaction energy is also positive.The free energy is negative -and thus chemisorption occurs-when the temperature are sufficiently high.The insights from this study will allow optimization of the adsorbent material for application in after-treatment systems for NO x elimination.
Polymer blends containing isotactic polystyrene: thermal behavior of model systems (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer blends containing isotactic polystyrene: thermal behavior of model systemsJames P. RuntCite this: Macromolecules 1981, 14, 2, 420–423Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ma50003a035https://doi.org/10.1021/ma50003a035research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Feasibility of Silicon-Based Mesoporous Materials for Oral Drug Delivery Applications (2008)

SUMMARY This review article presents a general overview of fabrication parameters and characterisation methodologies for various mesoporous silicon (PSi) materials. Some new data considering drug loading, drug dissolution/release enhancement and biological compatibility (cellular viability/toxicity) of the PSi materials are also discussed. Typically, the mesopores (pore diameters in the range of 2‐50 nm) are produced in the silicon wafers or particles by electrochemical etching in HF-solution. Subsequently, surface modification of the PSi is needed, since the hydrogen-terminated as-anodized surface is unstable and susceptible for oxidation. The etching process determines the pore architecture/ morphology, whereas the type of the surface modification determines the interactions of the material with the surrounding environment. With regards to oral drug delivery applications, the most important functions for the surfaces are to provide high drug payloads and to control the release of the molecules in a desired way by enhancing (or prolonging) the dissolution behaviour. The surface chemistry plays also a key role in the cellular interactions and putative toxicity of the PSi particles. Overall, the presented results on the feasibility, fabrication, characterisation, loading and release (incl. modelling), and cellular compatibility and safety, clearly confirm the fact that the meso-/nanoporous silicon materials may indeed offer a distinct advantage in dissolution enhancement and precisely controlled oral drug delivery applications. Moreover, the results of the newly developed toxicity assays also suggest that the mesoporous microparticles could be utilised in oral drug delivery formulations.
Enantioselective Synthesis of Nitroalkanes Bearing All‐Carbon Quaternary Stereogenic Centers Through Cu‐Catalyzed Asymmetric Conjugate Additions. (2005)

The first examples of catalytic asymmetric conjugate addition (ACA) of alkylzinc reagents to trisubstituted nitroalkenes, leading to the formation of nitroalkanes bearing a quaternary carbon stereogenic center, are reported. Reactions are promoted in the presence of 4 mol % of a readily available amino acid-based phosphine and 2 mol % (CuOTf)·C&lt;sub&gt;6&lt;/sub&gt;H&lt;sub&gt;6&lt;/sub&gt;. Cu-catalyzed reactions proceed efficiently in up to 98% ee and can be carried out with a variety of dialkylzinc reagents and trisubstituted nitroolefins. We highlight the synthetic utility of the products obtained by efficient conversion of optically enriched nitroalkanes to the corresponding carboxylic acids.
Chiral synthesis via organoboranes. Part 32. Synthesis of B-(cycloalk-2-enyl)diisopinocampheylboranes of high enantiomeric purity via the asymmetric hydroboration of cycloalka-1,3-dienes. successful asymmetric allylborations of aldehydes with B-(cycloalk-2-enyl)diisopinocampheylboranes (1991)

The hydroboration of cycloalka-1,3-dienes (CnH2n–4, n= 6, 7 and 8) with diisopinocampheylborane, (dIpc2BH or IIpc2BH) at –25°C provides highly enantiomerically pure B-(cycloalk-2-enyl)diisopinocampheylboranes, I or dIpc2BCnH2n–3( 93% ee). Surprisingly, these allylic borane derivatives retain their stereochemical integrity at –25 °C although such compounds are capable of undergoing racemization through rapid allylic rearrangements. Furthermore, the B-(cycloalk-2-enyl)diisopino-campheylboranes achieve allylborations of aldehydes at –78 °C and afford 1 -(cycloalk-2-enyl)alkan-1- ols in 90–95% ee and 100%syn-diastereoselectivity.
Relative fitness of susceptible and Cry1A.105/Cry2Ab2‐single‐/dual‐protein‐resistant Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) on non‐Bt diet and a diet containing a low concentration of two proteins (2022)

Helicoverpa zea (Boddie) is a destructive agricultural pest species that is targeted by both Bacillus thuringiensis (Bt) maize and cotton in the United States. Cry1A.105 and Cry2Ab2 are two Bt proteins expressed in a widely planted maize event MON 89034. In this study, two tests (Test-I and Test-II) were conducted to evaluate the relative fitness of Bt-susceptible and -resistant H. zea on non-Bt diet (Test-I and Test-II) and a diet containing a mix of Cry1A.105 and Cry2Ab2 at a low concentration (Test-II only). Insect populations evaluated in Test-I were two Bt-susceptible strains and three Bt-resistant strains (a single-protein Cry1A.105-, a single-protein Cry2Ab2-, and a dual-protein Cry1A.105/Cry2Ab2-resistant strains). Test-II analyzed the same two susceptible strains, three backcrossed-and-reselected Cry1A.105/Cry2Ab2-single-/dual-protein-resistant strains, and three F<sub>1</sub> heterozygous strains. Measurements of life table parameters showed that neither the single- nor dual-protein Cry1A.105/Cry2Ab2 resistance in H. zea was associated with fitness costs under the test conditions. The single Cry protein resistances at a concentration of a mix of Cry1A.105 and Cry2Ab2 that resulted in a zero net reproductive rate for the two susceptible strains were functionally incomplete recessive or codominant, and the dual-protein resistance was completely dominant. The lack of fitness costs could be a factor contributing to the rapid revolution of resistance to the Cry proteins in this species. Data generated from this study should aid our understanding of Cry protein resistance evolution and help in refining IRM programs for H. zea.
Selective isolation and eradication of E. coli associated with urinary tract infections using anti-fimbrial modified magnetic reduced graphene oxide nanoheaters (2017)

The fast and efficient elimination of pathogenic bacteria from water, food or biological samples such as blood remains a challenging task. Magnetic isolation of bacteria from complex media holds particular promise for water disinfection and other biotechnological applications employing bacteria. When it comes to infectious diseases such as urinary tract infections, the selective removal of the pathogenic species in complex media such as human serum is also of importance. This issue can only be accomplished by adding pathogen specific targeting sites onto the magnetic nanostructures. In this work, we investigate the potential of 2-nitrodopamine modified magnetic particles anchored on reduced graphene oxide (rGO) nanocomposites for rapid capture and efficient elimination of E. coli associated with urinary tract infections (UTIs) from water and serum samples. An optimized magnetic nanocarrier achieves a 99.9% capture efficiency even at E. coli concentrations of 1 × 10<sup>1</sup> cfu mL<sup>-1</sup> in 30 min. In addition, functionalization of the nanostructures with poly(ethylene glycol) modified pyrene units and anti-fimbrial E. coli antibodies allowed specific elimination of E. coli UTI89 from serum samples. Irradiation of the E. coli loaded nanocomposite with a near-infrared laser results in the total ablation of the captured pathogens. This method can be flexibly modified for any other pathogenic bacteria, depending on the antibodies used, and might be an interesting alternative material for a magnetic-based body fluid purification approach.
Characterization and Reliability of SiC- and GaN-Based Power Transistors. (2020)

Abstract not provided.
A novel simulation approach for fault injection resistance evaluation on smart cards (2015)

Physical perturbations are performed against embedded systems that can contain valuable data. Such devices and in particular smart cards are targeted because potential attackers hold them. The embedded system security must hold against intentional hardware failures that can result in software errors. In a malicious purpose, an attacker could exploit such errors to find out secret data or disrupt a transaction. Simulation techniques help to point out fault injection vulnerabilities and come at an early stage in the development process. This paper proposes a generic fault injection simulation tool that has the particularity to embed the injection mechanism into the smart card source code. By its embedded nature, the Embedded Fault Simulator (EFS) allows us to perform fault injection simulations and side-channel analyses simultaneously. It makes it possible to achieve combined attacks, multiple fault attacks and to perform backward analyses. We appraise our approach on real, modern and complex smart card systems under data and control flow fault models. We illustrate the EFS capacities by performing a practical combined attack on an Advanced Encryption Standard (AES) implementation.
A High Statistics Measurement of theΛc+Lifetime (2002)

A high statistics measurement of the Lambda(+)(c) lifetime from the Fermilab fixed-target FOCUS photoproduction experiment is presented. We describe the analysis technique with particular attention to the determination of the systematic uncertainty. The measured value of 204.6 +/- 3.4 (stat) +/- 2.5 (syst) fs from 8034 +/- 122 Lambda(+)(c)-->pK(-)pi(+) decays represents a significant improvement over the present world average.
Enabling Haptic Interaction with Volumetric MRI Data Through Knowledge-based Tissue Separation (2006)

Direct volume haptics can provide both guidance and extra information during exploration of volumetric data. In this paper we present a novel approach to volume haptics enabling haptic exploration of tissue shape, borders and material properties in data despite low contrast and low signal to noise ratio, as is common in medical MRI data or low dose CT data. The method uses filtering based on implicit knowledge and addresses the problem of overlapping scalar ranges through the introduction of fuzzy classification and corresponding transfer functions for material properties as well as classification-based distance masking for haptic force direction.