gebhart/patrepeval huggingface dataset:
Natural Rubber Composites for Paper Coating Applications (2020)

Natural rubbers are characterized by extremely high molecular weight that might be beneficial in the formation of a protective barrier layer on paper substrates, providing good cohesive properties but limited adhesion to the substrate. In parallel, the low glass transition temperature of natural rubber might give the opportunity for good sealability, in contrast with severe problems of tack. Therefore, natural rubbers can be good candidates to serve as an alternative ecological binder in paper coatings for water and grease barrier resistance. In order to tune the surface properties of the paper coating, the effect of different fillers in natural rubber coatings are evaluated on rheological, thermo–mechanical and surface properties. The fillers are selected according to common practice for the paper industry, including talc, kaolinite clay and a type of organic nanoparticle, which are all added in the range of 5 to 20 wt.-%. Depending on the selected natural rubber, the dispersibility range (i.e., dispersive and distributive mixing) of the fillers in the latex phase highly varies and filler/matrix interactions are the strongest for nanoparticle fillers. An optimum selection of viscosity range allows us to obtain homogeneous mixtures without the need of surface modification of the additives. After bar-coating natural rubber latex composites on paper substrates, the drying properties of the composite coatings are followed by spectroscopy, illustrating the influences of selected additives on the vulcanization process. In particular, the latter most efficiently improves in the presence of nanoparticle fillers and highly increases the coating hydrophobicity in parallel, reducing the adhesive tack surface properties, as predicted from calculated work of adhesion.
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse (2011)

PhosphoSitePlus (http://www.phosphosite.org) is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human and mouse proteins. It encompasses 1,30,000 non-redundant modification sites, primarily phosphorylation, ubiquitinylation and acetylation. The interface is designed for clarity and ease of navigation. From the home page, users can launch simple or complex searches and browse high-throughput data sets by disease, tissue or cell line. Searches can be restricted by specific treatments, protein types, domains, cellular components, disease, cell types, cell lines, tissue and sequences or motifs. A few clicks of the mouse will take users to substrate pages or protein pages with sites, sequences, domain diagrams and molecular visualization of side-chains known to be modified; to site pages with information about how the modified site relates to the functions of specific proteins and cellular processes and to curated information pages summarizing the details from one record. PyMOL and Chimera scripts that colorize reactive groups on residues that are modified can be downloaded. Features designed to facilitate proteomic analyses include downloads of modification sites, kinase-substrate data sets, sequence logo generators, a Cytoscape plugin and BioPAX download to enable pathway visualization of the kinase-substrate interactions in PhosphoSitePlus®.
PERFORMANCE TESTING IN PEOPLE WITH LOWER LIMB AMPUTATION: INTERVIEWS WITH PROSTHETISTS, PHYSICAL THERAPISTS, AND PHYSICIANS (2018)

INTRODUCTION&#x0D; A variety of performance-based tests are available to assess mobility in people with lower limb amputation (LLA)1. Selection of a specific test is likely to be guided by the clinical value of tasks patients perform; the space and equipment available to administrator the test; and/or the time required to set up, administer, score, and interpret the test results. The aim of this study was to collect information about the clinical value of performance tests, and the space, equipment, and time available to rehabilitation specialists who provide care to people with LLA (i.e., prosthetists, physical therapists (PTs), and physical medicine and rehabilitation (PM&amp;R) physicians).&#x0D; Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32018/24437&#x0D; How to cite: Balkman G, Morgan S, Gaunaurd I, Kristal A, Amtmann D, Gailey R, Hafner B.J. PERFORMANCE TESTING IN PEOPLE WITH LOWER LIMB AMPUTATION: INTERVIEWS WITH PROSTHETISTS, PHYSICAL THERAPISTS, AND PHYSICIANS. CANADIAN PROSTHETICS &amp; ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32018 &#x0D; Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. &#x0D; http://www.aopanet.org/
REVERSE SHOULDER ARTHROPLASTY: INDICATIONS AND RESULTS OF THE FRENCH MULTICENTER STUDY (2010)

Introduction: The reverse shoulder arthroplasty (RSA) is becoming increasingly common and the indications expanded. The objective of this study is to report the indications and results of RSA in a large multicenter study. Methodology: A retrospective, multicenter study was conducted including all RSA implanted between 1992 and 2002 in five centers in France. Of 457 patients involved in this study, 243 patients (53%) had cuff pathology: 149 had cuff tear arthropathy, 48 had massive cuff tears, and 45 had failed cuff surgery. Ninety-nine (22%) had revision of previous prostheses. Sixty (13%) had fracture-related problems. Twenty-six (6%) had osteoarthritis and two percent each had rheumatoid arthritis, tumors or other conditions. Three hundred and eighty-nine (85%) shoulders were available for review with greater than 2 years follow-up. The average age at review was 75.6 years (range, 22–92). The average follow-up was 43.5 months (range, 24–142). Results: Significant improvement was noted in Constant scores for pain (3.5 to 12.1), activity (5.8 to 15.1), mobility (12.1 to 24.5), and strength (1.3 to 6.1) (p Conclusions: The overall results of RSA are satisfactory and predictable. Functional results improved with improved active elevation, but no improvement in active internal and external rotation. However, results are dependent on the etiology.
Resolution-enhanced partial aperture imaging system using annular coded phase reflectors (2021)

Imaging with partial apertures is suitable for applications where compact, light-weight, and cost-effective optical systems are desired. The feasibility of a partial aperture imaging system (PAIS) with a single annular coded-phase aperture was first studied for future space and ground-based telescopic systems. The concept of PAIS is based on the interferenceless coded aperture correlation holography (I-COACH) technique. Since I-COACH is an incoherent and interferenceless technique, it is compatible with telescopic applications. Although, in PAIS, only a small fraction of light is modulated by the coded aperture the image resolution of PAIS is similar to that of full-aperture imaging systems. In this study, the design and the reconstruction technique of PAIS are modified to provide higher image quality with improved resolution, lower noise, and higher visibility. The upgraded design makes use of sparse-response holograms and a nonlinear reconstruction. Far-field imaging usually suffers from lower power signals at the sensor plane, causing a lower signal-to-noise ratio (SNR) and degradation in the image quality. To improve the SNR, it is crucial to use a power-efficient system, with higher signal intensity per camera pixel. This goal can be achieved by accumulating all the incoming power to a small sensor area, and distributing the light between several randomly distributed dots on the sensor, instead of inefficiently spreading the light over the entire camera plane. The results of the modified PAIS (M-PAIS) are reconstructed by a nonlinear correlation to provide well-resolved images which are compared with full aperture direct imaging results.
Reversible in vitro packing of nucleosomal filaments into globular supranucleosomal units in chromatin of whole chick erythrocyte nuclei. (1980)

Structural transitions between extended and condensed forms of chromatin have been studied by electron microscopy of whole chicken erythrocyte nuclei incubated in low buffer concentrations (0.5 mM sodium borate; 1 to 5 mM Tris-HCl) with and without additions of monovalent or divalent cations. Both spread preparations and ultrathin sections have been examined. It is shown that the condensed chromatin present in chicken erythrocytes is organized, at the supranucleosomal level, in granular particles (mean diameter 29 +/- 3 nM0 tightly apposed against each other in beaded chains (higher order fibrils). These chains of higher order granules are gradually unravelled in low salt buffers lacking divalent cations into extended nucleosomal filaments. When nuclear chromatin swollen in low salt buffer and extended uniformly into nucleosomal filaments is exposed to buffers containing higher concentrations of monovalent ions (e.g., 100 mM NaCl) or low concentrations of divalent cations (e.g., 0.05-0.5 mM MgCl2) rapid and almost complete recondensation of the entire chromatin of a nucleus into one compact spheroidal aggregate of chains of higher order granules (diameters 25-30 nm) is observed. This transition is reversible and whole nuclear chromatin can be induced, in vitro, to undergo several cycles of such conformational changes. The results show that reconstitution of globular forms of higher order packing of nucleosomes is not restricted to oligonucleosomal units but also takes place, in a rather uniform and regular mode, in long nucleosomal filaments as they are present in whole nuclei. The data are discussed in relation to other studies of chromatin ultrastructure and are interpreted to indicate that the predominant, if not exclusive form of supranucleosomal packing existing in condensed inactive chromatin of living cells is a chromatin fibril made up of serially arranged, close-packed granular particles ("suprabeads" sensu in [64]). In addition, the results suggest that higher order packing of chromatin into such supranucleosomal granules is not simply a function of ionic strength but that the type of ions present strongly influences the state of chromatin packing.
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor (2014)

BI 224436 is an HIV-1 integrase inhibitor with effective antiviral activity that acts through a mechanism that is distinct from that of integrase strand transfer inhibitors (INSTIs). This 3-quinolineacetic acid derivative series was identified using an enzymatic integrase long terminal repeat (LTR) DNA 3'-processing assay. A combination of medicinal chemistry, parallel synthesis, and structure-guided drug design led to the identification of BI 224436 as a candidate for preclinical profiling. It has antiviral 50% effective concentrations (EC50s) of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of >90 μM. BI 224436 also has a low, ∼2.1-fold decrease in antiviral potency in the presence of 50% human serum and, by virtue of a steep dose-response curve slope, exhibits serum-shifted EC95 values ranging between 22 and 75 nM. Passage of virus in the presence of inhibitor selected for either A128T, A128N, or L102F primary resistance substitutions, all mapping to a conserved allosteric pocket on the catalytic core of integrase. BI 224436 also retains full antiviral activity against recombinant viruses encoding INSTI resistance substitutions N155S, Q148H, and E92Q. In drug combination studies performed in cellular antiviral assays, BI 224436 displays an additive effect in combination with most approved antiretrovirals, including INSTIs. BI 224436 has drug-like in vitro absorption, distribution, metabolism, and excretion (ADME) properties, including Caco-2 cell permeability, solubility, and low cytochrome P450 inhibition. It exhibited excellent pharmacokinetic profiles in rat (clearance as a percentage of hepatic flow [CL], 0.7%; bioavailability [F], 54%), monkey (CL, 23%; F, 82%), and dog (CL, 8%; F, 81%). Based on the excellent biological and pharmacokinetic profile, BI 224436 was advanced into phase 1 clinical trials.
Geometric modeling based on polygonal meshes Video files associated with this course are available from the citation page (2007)

GCM
Preparation of the pointing and control system of the SOFIA Airborne Telescope for early science missions (2010)

During observation flights the telescope structure of the Stratospheric Observatory for Infrared Astronomy (SOFIA) is subject to disturbance excitations over a wide frequency band. The sources can be separated into two groups: inertial excitation caused by vibration of the airborne platform, and aerodynamic excitation that acts on the telescope assembly (TA) through an open port cavity. These disturbance sources constitute a major difference of SOFIA to other ground based and space observatories and achieving the required pointing accuracy of 1 arcsecond cumulative rms or better below 70 Hz in this environment is driving the design of the TA pointing and control system. In the current design it consists of two parts, the rigid body attitude control system and a feed forward based compensator of flexible TA deformation. This paper discusses the characterization and control system tuning of the as-built system. It is a process that integrates the study of the structural dynamic behavior of the TA, the resulting image motion in the focal plane, and the design and implementation of active control systems. Ground tests, which are performed under controlled experimental conditions, and in-flight characterization tests, both leading up to the early science performance capabilities of the observatory, are addressed.
Single-frequency low-threshold linearly polarized DFB Raman fiber lasers (2017)

Distributed feedback (DFB) fiber lasers have been demonstrated to be excellent narrow-linewidth (kilohertz range) single-frequency laser sources. However, this type of laser is normally limited to rare-earth-doped fibers. Raman gain offers an alternative, operating at any arbitrary wavelength. We demonstrate here linearly polarized, single-frequency, DFB fiber Bragg grating Raman lasers with, to the best of our knowledge, the lowest pump threshold of 350 mW, an output power of up to 50 mW at 1120 nm, an 8.5% slope efficiency, and 300 mW of output power at 1178 nm. In the high-power regime, stimulated Brillouin scattering plays an important role in the laser dynamics. We also report the characterization of the power profile inside the fiber along its axis through a novel side-scatter technique.
Protest der Physiker (2011)

Und die Physik dreht sich doch um die Moral – ein gutes Jahrzehnt nach Hiroshima verfassten deutsche Physiker von Weltrang ein öffentliches Manifest gegen Atomwaffen. Ein aktueller Blick auf eine der Urszenen der deutschen Anti-Atomkraft-Bewegung.
ChemInform Abstract: EPOXYANNELATION: NEW REACTION PATH FOR BUTADIENYLSULFONIUM SALTS (1979)

Abstract Cyclohexanon (I) bzw. sein Enolsilylether (II) reagieren mit dem Butadienylsulfoniumsalz (III) zum cyclischen Epoxid und den isomeren Substitutionsprodukten (V).
Additively manufactured mesh-type titanium structures for cranial implants: E-PBF vs. L-PBF (2021)

A patient-specific titanium-reinforced calcium phosphate (CaP–Ti) cranial implant has recently shown promising clinical results. Currently, its mesh-type titanium structure is additively manufactured using laser beam powder bed fusion (L-PBF). Nevertheless, an electron-beam (E-PBF) process could potentially be more time efficient. This study aimed to compare the geometrical accuracy and mechanical response of thin titanium structures manufactured by L-PBF (HIPed) and E-PBF (as-printed). Tensile test (ø = 1.2 mm) and implant specimens were manufactured. Measurements by μCT revealed a deviation in cross-sectional area as compared to the designed geometry: 13–35% for E-PBF and below 2% for L-PBF. A superior mechanical strength was obtained for the L-PBF specimens, both in the tensile test and the implant compression tests. The global peak load in the implant test was 457 ± 9 N and 846 ± 40 N for E-PBF and L-PBF, respectively. Numerical simulations demonstrated that geometrical deviation was the main factor in implant performance and enabled quantification of this effect: 34–39% reduction in initial peak force based on geometry, and only 11–16% reduction based on the material input. In summary, the study reveals an uncertainty in accuracy when structures of sizes relevant to mesh-type cranial implants are printed by the E-PBF method.
Complex Phase Behavior of Polyisoprene-Polystyrene Diblock Copolymers Near the Order-Disorder Transition (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplex Phase Behavior of Polyisoprene-Polystyrene Diblock Copolymers Near the Order-Disorder TransitionStephan Foerster, Ashish K. Khandpur, Jin Zhao, Frank S. Bates, Ian W. Hamley, Anthony J. Ryan, and Wim BrasCite this: Macromolecules 1994, 27, 23, 6922–6935Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ma00101a033https://doi.org/10.1021/ma00101a033research-articleACS PublicationsRequest reuse permissionsArticle Views2794Altmetric-Citations388LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model (2021)

Two types of gene transfer techniques were successfully applied to a canine model, and the transduced gene expressions persisted for a long term. Toward clinical application for hemophilia patients, practical assessments of therapeutic efficacy of these techniques will need to be performed using a dog model of hemophilia and FVIII (or FIX) gene.
Simulating haplotype blocks in the human genome (2003)

The SNPsim package is available at http://www.evolgenics.com/software
The Effect of Sulphur-Free Diesel Fuel on the Measurement of the Number and Size Distribution of Particles Emitted from a Heavy-Duty Diesel Engine Equipped with a Catalysed Particulate Filter (2003)

&lt;div class="htmlview paragraph"&gt;Following concern about the association between adverse health effects and ambient particulate concentrations, there are now an increasing number of heavy-duty Diesel engines fitted with catalysed particulate filters. These filters virtually eliminate carbon particle emissions but there is some evidence suggesting a potential to form a cloud of secondary nucleation particles post trap. This event occurs at high temperature operating conditions and is produced mainly from the increased sulphate production over the catalyst. This paper investigates the measurement of particle emissions from a heavy-duty engine operating over the European legislated cycle, both with and without a filter fitted and investigates how emissions are affected by the use of a sulphur-free Diesel fuel. The work also demonstrates a contribution to the measured nucleation particles from material desorbed not only from the trap, but also from the exhaust system.&lt;/div&gt;
Metabolism of emulsions containing medium- and long-chain triglycerides or interesterified triglycerides (1994)

This study compares the clearing and metabolism of three different lipid emulsions. They had the same phospholipid emulsifier and similar particle sizes. In one (LLL) the core component was long-chain triglycerides (TG), the second (MMM/LLL) contained equal molar amounts of medium- and long-chain TG, the third (MLM) contained synthetic TG with medium-chain (M) fatty acids in the 1,3-positions and a long-chain (L) fatty acid in the 2-position. In model experiments with bovine lipoprotein lipase, the MMM component was hydrolyzed preferentially in the MMM/LLL emulsion so that the initial products were M fatty acids and M monoglycerides. The MLM emulsion, in contrast, gave M fatty acids and formation of L-MG (monoglyceride) throughout hydrolysis. For in vivo studies [3H]oleic acid was incorporated into the emulsion TG as marker for the long-chain component. After bolus injection to rats, the MMM/LLL and MLM emulsions were cleared more rapidly than the LLL emulsion. This was true at all TG loads studied (4-64 mg for a 200 g rat). The labeled oleic acid was oxidized somewhat more rapidly when administered in the MLM emulsion compared to the MMM/LLL emulsion. There were only slight differences in tissue distribution of label. Hence, differences in in vivo metabolism of the long-chain fatty acids were small compared to the marked differences in TG structure and in patterns of product release during in vitro lipolysis.
New Amines for CO2 Capture. IV. Degradation, Corrosion, and Quantitative Structure Property Relationship Model (2012)

Degradation of 22 compounds was evaluated in stainless steel batch reactors at 140 °C for 14 days under a pressure of 0.5 MPa (mixture of 75% CO2, 20% N2, and 5% O2). For each run, two corrosion coupons, one carbon steel (XC38) and one stainless steel (304Ti), were immersed in aqueous solutions of amines to determine corrosion due to degraded solutions. Two additional coupons were put in the vapor phase above solutions. At the end of the run, corrosion rates were evaluated through weight-loss measurements. The amounts of remaining starting material were determined with a quantitative gas chromatography method. Corrosion and degradation data were compared with those of a benchmark molecule (MEA, monoethanolamine), tested under the same conditions. Results indicate that some molecules are less corrosive and have a better chemical stability than MEA. In addition, a quantitative structure property relationship (QSPR) model was built that can be applied to predict compound degradation.
ChemInform Abstract: Synthesis and Anti‐HIV‐1 Activities of New Pyrimido[5,4‐b]indoles. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Longitudinal study of retinal status using optical coherence tomography after acute onset endophthalmitis following cataract surgery (2017)

ERM and ME were the main macular abnormalities diagnosed after 1 year of follow-up, associated with VA less than or equal to 20/40 in 50% of the cases. Ultrastructural abnormalities of the ELM and the ellipsoid band were frequently observed in those patients.