gebhart/patrepeval huggingface dataset:
AKAP 18 α and γ have opposing effects on insulin release in INS‐1E cells (2009)

A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 alpha or gamma expression results in decreased or increased glucose-stimulated insulin secretion in INS-1E cells. Glucose stimulates AKAP 18 alpha and inhibits AKAP 18 gamma mRNA expressions while palmitate markedly reduces AKAP 18 alpha expression. Human growth hormone (GH) stimulates AKAP 18 alpha expression and attenuates palmitate-induced suppression of AKAP 18 alpha mRNA level. The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.
A Sequential Binding Mechanism in a PDZ Domain (2009)

Conformational selection and induced fit are two well-known mechanisms of allosteric protein-ligand interaction. Some proteins, like ubiquitin, have recently been found to exist in multiple conformations at equilibrium, suggesting that the conformational selection may be a general mechanism of interaction, in particular for single-domain proteins. Here, we found that the PDZ2 domain of SAP97 binds its ligand via a sequential (induced fit) mechanism. We performed binding experiments using SAP97 PDZ2 and peptide ligands and observed biphasic kinetics with the stopped-flow technique, indicating that ligand binding involves at least a two-step process. By using an ultrarapid continuous-flow mixer, we then detected a hyperbolic dependence of binding rate constants on peptide concentration, corroborating the two-step binding mechanism. Furthermore, we found a similar dependence of the rate constants on both PDZ and peptide concentration, demonstrating that the PDZ2-peptide interaction involves a precomplex, which then undergoes a conformational change, and thereby follows an induced fit mechanism.
Cross-stream-line migration in confined flowing polymer solutions: Theory and simulation (2006)

Theory and Brownian dynamics (BD) simulations are used to study cross-stream migration in confined dilute flowing polymer solutions, using bead-spring chain and dumbbell models for the polymer molecules. Different degrees of confinement are explored, from a chain above a single wall to slits whose widths 2h are much bigger than the polymer contour length L and radius of gyration Rg (2h⪢L⪢Rg), much bigger than the radius of gyration but comparable with the contour length (2h∼L&amp;gt;Rg), and comparable with the polymer radius of gyration (2h∼Rg). The results show that except in the latter case, polymer chains migrate in shear flow away from the confining surfaces due to the hydrodynamic interactions between chains and walls. In contrast, when 2h∼Rg, the chain migration in flow is toward the walls. This is a steric effect, caused by extension of the chain in the flow direction and corresponding shrinkage of the chains in the confined direction; here the hydrodynamic effects of each wall cancel one another out. Considering the polymer chain as a Stokeslet-doublet (point-force-dipole) as in a previously developed kinetic theory captures the correct far-field (relative to the walls) behavior. Once a finite-size dipole is used, the theory improves its near-wall predictions. In the regime 2h∼L&amp;gt;Rg, the results are significantly affected by the level of discretization of the polymer chain, i.e., number of springs, because the spatial distribution of the forces exerted by the chain on the fluid acts on the scale of the channel geometry.
Comments on "High-speed area-efficient multiplier design using multiple-valued current-mode circuits" (1996)

S. Kawahito et al. (1988) presented multiplier designs using the binary-tree reduction feature of certain highly redundant radix-2 representations, along with multiple-valued current-mode circuit techniques, and shown them to compare favorably to those based on less redundant binary signed-digit and carry-save numbers. We point out that these representation schemes, and their potential advantages, have been discussed in earlier publications and that a more general view of the parallel-carries addition process exploited in these multipliers leads to other potentially useful representations. The authors reply is also given.
Finite Element Analysis of Wear Resistance Mechanism of Bionic Non-smooth Through-hole (2007)

利用ANSYS软件,以平板试件为对比基准,对具有仿生非光滑通孔结构试件的耐磨机制进行了有限元分析.分析表明,仿生非光滑通孔具有削弱应力集中、均匀分布应力的功能,使试件整体受力均匀、接触状态良好,从而提高试件的摩擦磨损性能;通孔附近前大后小的应力分布方式,有利于收集润滑油、切削磨粒,改善其润滑状态,减小磨粒磨损.
Video Rate Fluorescence Lifetime Imaging and Fluorescence Lifetime Endoscopy (2005)

We report real-time (video-rate) fluorescence lifetime imaging and its application to tissue autofluorescence and endoscopy, demonstrating FLIM of unstained ex vivo tissue at update rates of 5.5 Hz through a flexible endoscope.
In vitrooxidations of low-density lipoprotein and RAW 264.7 cells with lipophilic O(3P)-precursors (2020)

A beneficial property of photogenerated reactive oxygen species (ROS) is the capability of oxidant generation within a specific location or organelle inside a cell. Dibenzothiophene <i>S</i>-oxide (DBTO), which is known to undergo a photodeoxygenation reaction to generate ground state atomic oxygen [O(<sup>3</sup>P)] upon irradiation, was functionalized to afford localization within the plasma membrane of cells. The photochemistry, as it relates to oxidant generation, was studied and demonstrated that the functionalized DBTO derivatives generated O(<sup>3</sup>P). Irradiation of these lipophilic O(<sup>3</sup>P)-precursors in the presence of LDL and within RAW 264.7 cells afforded several oxidized lipid products (oxLP) in the form of aldehydes. The generation of a 2-hexadecenal (2-HDEA) was markedly increased in irradiations where O(<sup>3</sup>P) was putatively produced. The substantial generation of 2-HDEA is not known to accompany the production of other ROS. These cellular irradiation experiments demonstrate the potential of inducing oxidation with O(<sup>3</sup>P) in cells.
Concise Synthesis of dl-Febrifugine (2005)

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an omega-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).
LTE Radiated Data Throughput Measurements, Adopting MIMO 2x2 Reference Antennas (2012)

Long Term Evolution (LTE) requires Multiple Input Multiple Output (MIMO) antenna systems. Consequently a new over-the-air (OTA) test methodology need to be created to make proper assessment of LTE devices radiated performance. The antenna specific parameters i.e. total antenna efficiency, gain imbalance and correlation coefficient, are essential for a proper MIMO antenna system design. However it can't be use directly to assess the LTE device system performance, since a multiplicity of other factors are involved, e.g. power amplifier load- pull, low noise amplifier source-pull, self interference noise, baseband algorithm and other factors. Several standard organizations are working towards a consensus over the proper OTA MIMO test method, however so far results of measurement campaigns have ambiguous results not allowing a desirable progress [1]. Initially presented at one of several MIMO OTA standard meetings [2], the reference antenna was conceived considering the special case of uniform distribution of incoming power. This paper shows an antenna system that will aid standard organizations and research labs adopting anechoic or reverberation chambers to proper investigate OTA radiated performance, ruling out the LTE devices unknown MIMO 2x2 antenna performance.
Discriminator-Actor-Critic: Addressing Sample Inefficiency and Reward\n Bias in Adversarial Imitation Learning (2018)

We identify two issues with the family of algorithms based on the Adversarial\nImitation Learning framework. The first problem is implicit bias present in the\nreward functions used in these algorithms. While these biases might work well\nfor some environments, they can also lead to sub-optimal behavior in others.\nSecondly, even though these algorithms can learn from few expert\ndemonstrations, they require a prohibitively large number of interactions with\nthe environment in order to imitate the expert for many real-world\napplications. In order to address these issues, we propose a new algorithm\ncalled Discriminator-Actor-Critic that uses off-policy Reinforcement Learning\nto reduce policy-environment interaction sample complexity by an average factor\nof 10. Furthermore, since our reward function is designed to be unbiased, we\ncan apply our algorithm to many problems without making any task-specific\nadjustments.\n
Therapeutic and prophylactic effects of some antibiotics on experimental pneumonic pasteurellosis. (1984)

Pneumonic pasteurellosis was produced in cattle seronegative for bovine herpes virus-1 and Pasteurella haemolytica using their respective aerosols four days apart. When treated with four daily intravenous oxytetracycline injections one day prior, same day as and 24 hours after P. haemolytica aerosols cattle experienced a reduced mortality. Prophylactic sustained action antibiotics given 24 hours prior to the P. haemolytica aerosol also reduced mortality, however there appeared to be a variation associated with the products used.
Perfect Tilings of Binary Spaces (2005)

We study partitions of the space F/sup n//sub 2// of all the binary n-tuples into disjoint sets, such that each set is an additive coset of a given set V. Such a partition is called a perfect tiling of F/sup n/sub 2// and denoted (V, A), where A is the set of coset representatives. A sufficient condition for a set V to be a tile is given in terms of the cardinality of V+V. A perfect tiling (V, A) is said to be proper if V generates F/sup n/sub 2//. We show that the classification of perfect tilings can be reduced to the study of proper perfect tilings. We then prove that each proper perfect tiling is uniquely associated with a perfect binary code. A construction of proper perfect tilings from perfect binary codes is presented. Furthermore, we introduce a class of perfect tilings obtained by iterating a simple recursive construction. Finally, we generalize the well-known Lloyd theorem, originally stated for tilings by spheres, for the case of arbitrary perfect tilings.
Low Emittance Growth In a LEBT With Un-Neutralized Section (2017)

In a Low Energy Beam Transport line (LEBT), the emittance growth due to the beam's own space charge is typically suppressed by way of neutralization from either electrons or ions, which originate from ionization of the background gas. In cases where the beam is chopped, the neutralization pattern changes throughout the beginning of the pulse, causing the Twiss parameters to differ significantly from their steady state values, which, in turn, may result in beam losses downstream. For a modest beam perveance, there is an alternative solution, in which the beam is kept un-neutralized in the portion of the LEBT that contains the chopper. The emittance can be nearly preserved if the transition to the un-neutralized section occurs where the beam exhibits low transverse tails. This report discusses the experimental realization of such a scheme at Fermilab's PXIE, where low beam emittance dilution was demonstrated.
Chinese teachers’ perceptions of academically oriented teacher preparation (2017)

Academically oriented teacher preparation, which prioritises subject matter knowledge for teaching, is still widely practised in Confucian societies. Few studies, however, have investigated the impact of this academic model on teaching practices in Confucian contexts. Drawing on interviews and classroom observations of six Chinese mathematics teachers, this study identifies the affordances and limitations of a typical academically oriented teacher preparation in today’s China. Although this helped the sampled teachers establish their initial self-efficacy for teaching it limited the teachers’ awareness of and their capacity for engaging all students to learn. The paper argues that academically oriented teacher preparation programmes in Confucian societies may need to reform their curricula so as to help their graduates advance both excellence and equity in education through their teaching.
Complexity Reduced Carrier Recovery Using Spread Spectrum for Low CNR Environment (2016)

Low data-rate communication is an effective approach for Internet of things (IoT) devices such as measurement nodes of wireless sensor networks which are required to operate at very low power. While a method which enables the receivers to perform the accurate carrier recovery for low-CNR and low-data-rate communication was proposed, the major difficulty has been its computational complexity. This paper proposes novel methods that reduce the complexity of the carrier recovery process. The proposed methods consist of two approaches: carrier recovery using a trellis diagram, and adaptive control of the parameter of the algorithm. The performance evaluation by computer simulations and experiments showed that the proposed methods reduce the complexity of the carrier recovery significantly.
Humidity and the Anesthetized Patient (1979)

CHALON, J.; PATEL, C.; ALI, M.; RAMANTHAN, S.; CAPLAN, L.; TANG, C.; TURNDORF, H. Author Information
Increased utilization of prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (PSMA-TRT) in African American (AA) patients at an academic medical center. (2023)

36 Background: At Weill Cornell Medicine (WCM), we have had a research program utilizing anti-PSMA mAb J591 since the year 2000. With the addition of PSMA ligand-based therapies in 2017, we have enrolled around 300 patients on investigational PSMA-TRT clinical trials. Since the approval of 177 Lu-PSMA-617 (Pluvicto; Lu-177 vipivotide tetraxetan), we began standard-of-care (SOC) treatment, co-enrolling willing patients into a research registry. Recognizing the low numbers of AA patients enrolled on therapeutic clinical trials in the U.S., we made a concerted effort to increase the number of AA patients with prostate cancer (PC) enrolled on clinical trials at WCM. We retrospectively assessed the demographic data of patients enrolled on PSMA-TRT clinical trials to determine changing patterns of enrollment, and to determine if our efforts have improved access to these novel treatments for this under-represented, but high-risk population of patients. Methods: We collected demographic data (namely race and ethnicity) on patients with PC from WCM who were included on our PSMA-TRT investigational clinical trial databases or enrolled on our SOC 177 Lu-PSMA-617 research registry. We used self-reported race and, when not available (due to patient death or loss of follow-up), demographic information documented in the medical record. Patients were grouped into 5-year cohorts based on either the date of consent for trial enrollment, or the start date of PSMA-TRT treatment (based on available information). Institutional tumor registry data was used as a comparator to assess the total percentage of AA patients with PC seen at WCM. Results: The percentages of patients included on PSMA-TRT clinical trials at WCM who were identified as AA were as follows: 2000-2004: 3.1% (2/65), 2005-2009: 5.1% (3/59), 2010-2014: 6.1% (2/33), and 2015-2019: 5.9% (5/85). The percentage of AA patients on PSMA-TRT studies from 2020 through July 2022 was 18.2% (16/88, inclusive of 8/72 investigational TRT subjects and 8/16 SOC registry participants). The total percentages of AA patients seen at Cornell based upon analysis of our tumor registry data were as follows: 2000-2004: 10.5% (182/1728), 2005-2009: 6.9% (250/3607), 2010-2014: 10% (326/3255), 2015-2019: 11.5% (278/2413), and 2020: 14.1%. Tumor registry data for 2021-present were not yet available. Conclusions: The percentage of AA patients on investigational PSMA-TRT trials at our institution notably increased from 2000-2019 (3.1%-6.1%) to 2020-2022 (11.1%). Moreover, 50% of those treated with 177 Lu-PSMA-617 since its FDA approval and co-enrolled on our research registry identified as AA. These data suggest that outreach and increasing access to AA patients for novel PC treatment such as PSMA-TRT can result in increased numbers of underrepresented patients enrolling on clinical trials and receiving the most modern standards of care (i.e., PSMA-TRT).
Production of $${\pi ^0}$$ π 0 and $$\eta $$ η mesons up to high transverse momentum in pp collisions at 2.76 TeV (2017)

The invariant differential cross sections for inclusive [Formula: see text] and [Formula: see text] mesons at midrapidity were measured in pp collisions at [Formula: see text] TeV for transverse momenta [Formula: see text] GeV/<i>c</i> and [Formula: see text] GeV/<i>c</i>, respectively, using the ALICE detector. This large range in [Formula: see text] was achieved by combining various analysis techniques and different triggers involving the electromagnetic calorimeter (EMCal). In particular, a new single-cluster, shower-shape based method was developed for the identification of high-[Formula: see text] neutral pions, which exploits that the showers originating from their decay photons overlap in the EMCal. Above 4 GeV/[Formula: see text], the measured cross sections are found to exhibit a similar power-law behavior with an exponent of about 6.3. Next-to-leading-order perturbative QCD calculations differ from the measured cross sections by about 30% for the [Formula: see text], and between 30-50% for the [Formula: see text] meson, while generator-level simulations with PYTHIA 8.2 describe the data to better than 10-30%, except at [Formula: see text] GeV/[Formula: see text]. The new data can therefore be used to further improve the theoretical description of [Formula: see text] and [Formula: see text] meson production.
Silicon Bioscience in Bacteria (2011)

バクテリアがシリコンを蓄積する生理的な意味は，胞子の表面にシリカ層をつくり出すことによって耐酸性を高めていることであった．バクテリアのシリコン代謝の解析を通して，偶然にも2001年のアメリカ炭疸菌バイオテロの謎の一部を解くことになった．ハイテク技術に不可欠のシリコンとバイオが結びついたシリコンバイオサイエンスの応用展開が期待される．
Service Platform for Converged Interactive Broadband Broadcast and Cellular Wireless (2007)

A converged broadcast and telecommunication service platform is presented that is able to create, deliver, and manage interactive, multimedia content and services for consumption on three different terminal types. The motivations of service providers for designing converged interactive multimedia services, which are crafted for their individual requirements, are investigated. The overall design of the system is presented with particular emphasis placed on the operational features of each of the sub-systems, the flows of media and metadata through the sub-systems and the formats and protocols required for inter-communication between them. The key features of tools required for creating converged interactive multimedia content for a range of different end-user terminal types are examined. Finally possible enhancements to this system are discussed. This study is of particular interest to those organizations currently conducting trials and commercial launches of DVB-H services because it provides them with an insight of the various additional functions required in the service provisioning platforms to provide fully interactive services to a range of different mobile terminal types
Plasma sputtering deposition of PEMFC porous carbon platinum electrodes (2008)

in press. available online Nov. 2007
On SVQ Shaping of Multidimensional Constellations - High-Rate Large-Dimensional Constellations (1992)

An optimal shaping scheme for multidimensional constellations, motivated by some ideas from a fixed-rate structured vector quantizer (SVQ), was recently proposed by Laroia. It was shown that optimal shaping could be performed subject to a constraint on the CER2 or PAR2 by expressing the (optimally shaped) constellation as the codebook of an SVQ and using the SVQ encoding/decoding algorithms to index the constellation points. Further, compatibility with trellis coded modulation was demonstrated. The complexity of the proposed scheme was reasonable but dependent on the data transmission rate. In this paper, we use recent results due to Calderbank and Ozarow to show that complexity of this scheme can be reduced and made independent of the data rate with essentially no effect on the shaping gain. Also, we modify the SVQ encoding/decoding algorithms to reduce the implementation complexity even further. It is shown that SVQ shaping can achieve a shaping gain of about 1.20 dB with a PAR2 of 3.75 at a very reasonable complexity (about 15 multiply-adds/baud and a memory requirement of 1.5 kbytes). Further, a shaping gain of 1 dB results in a PAR2 of less than 3. This is considerable less than a PAR2 of 3.75 for Forney's trellis shaping scheme that gives about 1 dB shaping gain.
Hydrophilic Solute Release from a Hydrophobic Elastic Matrix (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrophilic Solute Release from a Hydrophobic Elastic MatrixDaniel Brown, You Han Bae, and Sung Wan KimCite this: Macromolecules 1994, 27, 18, 4952–4959Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ma00096a016https://doi.org/10.1021/ma00096a016research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Separating Astigmatic Mirror Figure Error from Alignment Induced Misalignment Aberrations using Nodal Aberration Theory (2009)

Nodal aberration theory (NAT) has revealed that misalignment astigmatism displays a different signature field dependence than signature nodal positions caused by astigmatic mirror figure error. These differences will be derived and demonstrated for astronomical telescopes.
28.2: Tiled Display Utilizing Ceramic Actuators for Large Area Flat Panels (2001)

Abstract We have developed a novel display device driven by micro ceramic actuator arrays. Typically 60–150 inch diagonal size direct viewing flat display can be flexibly built up by tiled display technology with non‐seal structure. We successfully built up 33 inch engineering model display.
Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. (2001)

This study identified no statistically significant evidence for a link between MYOC mutations and steroid-induced ocular hypertension.
GUARDRAIL TESTING - MODIFIED ECCENTRIC LOADER TERMINAL (MELT) AT NCHRP 350 TL-2 (2002)

Performed by Texas Transportation Institute, Texas A &amp;#38; M University.; "July 2002."; "NETCR 35, Project No. 00-5."; Includes bibliographical references (p. 67-68).; Final report.; Sponsored by New England Transportation Consortium, University of Connecticut; Harvested from the web on 5/3/06