gebhart/patrepeval huggingface dataset:
Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants (2007)

Variants in CACNA1H that alter channel properties are present in patients with various generalized epilepsy syndromes. We propose that these variants contribute to an individual's susceptibility to epilepsy but are not sufficient to cause epilepsy on their own. The genetic architecture is dominated by rare functional variants; therefore, CACNA1H would not be easily identified as a susceptibility gene by a genome-wide case-control study seeking a statistical association.
Facilitating shared vision in the organization (2003)

The current paper presents a structured method helping organizational facilitators to work efficiently with their clients. Through this method it is possible to motivate and encourage top executive team efficiently to willingly generate true vision and mission and implement these in the organization for achieving both improved performance and harmony.
Sensitivity-Enhanced NMR of Biological Solids:  Dynamic Nuclear Polarization of Y21M fd Bacteriophage and Purple Membrane (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSensitivity-Enhanced NMR of Biological Solids: Dynamic Nuclear Polarization of Y21M fd Bacteriophage and Purple MembraneMelanie Rosay, Ana-Carolina Zeri, Nathan S. Astrof, Stanley J. Opella, Judith Herzfeld, and Robert G. GriffinView Author Information Department of Chemistry and Francis Bitter Magnet Laboratory Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Department of Chemistry, University of Pennsylvania Philadelphia, Pennsylvania 19104 Department of Chemistry and Keck Institute for Cellular Visualization, Brandeis University Waltham, Massachusetts 02454 Cite this: J. Am. Chem. Soc. 2001, 123, 5, 1010–1011Publication Date (Web):January 13, 2001Publication History Received2 October 2000Revised7 December 2000Published online13 January 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/ja005659jhttps://doi.org/10.1021/ja005659jrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views579Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electromagnetic radiation,Granular materials,Nuclear magnetic resonance spectroscopy,Polarization,Viruses Get e-Alerts
Effect of Surface Oxygen Groups and Water on Hydrogen Spillover in Pt-Doped Activated Carbon (2011)

The synergistic role of increased oxygen functional groups and water on hydrogen adsorption via hydrogen spillover is explored. A potassium hydroxide (KOH) treatment is used to increase the surface density of oxygen groups on a high surface area-activated carbon (AC), which serves as a secondary receptor for hydrogen spillover after physical mixing with a common Pt-based spillover catalyst. Consistent with previous results, XPS shows that KOH treatment increases atomic concentration of oxygen and the fraction of carbonyl/quinone groups on the surface of the AC. Increased surface density of oxygen groups leads to a significant enhancement of hydrogen spillover at pressures <100 mbar. At 300 K, the hydrogen uptake is 1.1 wt % at 100 mbar and increases to 1.4 wt % at 20 bar. However, only 0.4 wt % of this is desorbable via a pressure reduction at room temperature, and appreciable spillover is observed only when trace water is present during pretreatment. The trace water is believed to affect the development of active surface sites based on characterization of the development of oxygen groups by XPS and FTIR. The synergistic role of oxygen groups and water and a plausible mechanism on the effect on hydrogen isotherms are discussed.
Power Electronics and Drives: Applications to Modern Ship Propulsion Systems (2020)

Electrically propelled ships gained popularity by the early 20th century, with the rapid development of submarines and mediumcapacity container ships, mainly using dc motors [1]. Synchronous ac motors have since been employed for naval propulsion systems, but due to the restricted operation of the available power electronic devices at that time, these configurations were too expensive and unreliable, and they featured poor performance in terms of speed and torque control [2]. Improvements in power electronics devices and drive control schemes as well as the development of high-efficiency multiphase induction and synchronous motors have pushed the advancement of electric ship propulsion systems and applications [3]-[7].
Population immunity to measles in Canada using Canadian Health Measures survey data – A Canadian Immunization Research Network (CIRN) study (2022)

We aimed to determine population immunity to measles in Canada, and to assess the risk of future outbreaks. We tested 11,176 sera from Cycles 2 (2009-2011) and 3 (2011-2013) cohorts from the biobank of Statistics Canada's Canadian Health Measures Survey (CHMS) using the BioPlex 2220 MMRV IgG assay. We then tested all BioPlex negative and equivocal samples using a more sensitive Plaque Reduction Neutralization Test (PRNT). We determined the weighted proportion of positive, equivocal, and negative samples by age, sex, region and whether individuals were born in Canada. We found that 90.0% (95% confidence interval (CI): 88.2, 91.9) of samples were positive, 4.5% (95% CI: 3.4, 5.5) were equivocal and 5.5% (95% CI: 4.3, 6.7) were negative. Individuals in the 12-19 year age band had the lowest proportion positive at 78.7% (95% CI: 74.2, 83.2) and the highest proportion of positive samples was found in those 60-79 years (99.6%, 95% CI: 99.3, 99.9). Seropositivity was consistently <90% across a broad range of pediatric and adult age bands (6-39 years). We found that a slightly higher proportion of females were positive (91.9%, 95% CI: 90.1, 93.6) compared to males (88.3%, 95% CI: 85.8, 90.7). When taking into account interaction between age and born in Canada status, we found individuals born in Canada aged 19 and under were less susceptible (OR = 0.6 (95% CI: 0.4, 0.95)) compared to those born outside Canada whereas, those aged 20 and over were more susceptible (OR = 1.7 (95% CI: 1.1, 2.8)). Our findings indicate that measles immunity in Canada is below the 95% immunity threshold required to sustain measles elimination, underscoring the importance of maintaining high vaccine coverage to prevent future measles outbreaks and sustain Canada's elimination status.
Lost‐shell casting for rapid prototyping in RF and microwave applications (2018)

Lost‐shell casting as a novel fabrication technique is examined, providing the durability of solid metal components with the shape flexibility of additive manufacturing. The feasibility of lost‐shell casting is established for use in microwave and RF applications. A well known, standard rectangular cavity resonator design was used to validate this novel method of fabrication. Using lost‐shell casting, a cavity resonator with a quality factor of 2200 was constructed. The results shown in this work confirm the validity of lost‐shell casting as a novel method of rapid fabrication for completely metalised components in RF and microwave applications.
COMPARISON OF PERCUTANEOUS WITH INTRA‐OPERATIVE BALLOON ANGIOPLASTY FOR ARTERIOSCLEROTIC OCCLUSIVE DISEASE (1993)

The purpose of this study was to compare the technical success and short-term outcome of intraoperative balloon angioplasty (IBA) with percutaneous transluminal angioplasty (PTA) in the iliac and femoropopliteal segment. From January 1988 to February 1991, 99 consecutive patients underwent 114 angioplasties in the iliac (37 PTA, 26 IBA) and femoropopliteal segment (15 PTA, 36 IBA). Mean age and sex distributions were similar between the groups. Claudication was the primary indication for both groups. All patients who underwent IBA had another concomitant surgical procedure performed. Immediate technical success for PTA and IBA were 50/52 (96%) and 58/62 (94%), respectively. Cumulative patency up to 12 months following angioplasty of the iliac artery was 94% for PTA and 78% for IBA (P-value NS). For the femoropopliteal segment, 12 month patency results were 100% for PTA and 78% for IBA (P-value NS). Complications requiring surgical intervention occurred in 3 (6%) PTA and 5 (8%) IBA cases. Results from this study indicate that technical success and early patency are similar for PTA and IBA in the iliac and femoropopliteal segments. However angioplasty-related complications were not avoided by performing balloon angioplasty in the operating room.
HIGH OUTPUT CURRENT STABILITY OF POWER SUPPLY (2000)

Correction magnets of synchrotron storage ring are served with linear power supplies (correction power supply) with ±100 ppm long-term stability in Synchrotron Radiation Research Center (SRRC). Low efficiency of linear power supply would increase the temperature inside of rack of power supply such that current stability is difficult to maintain because devices of control circuitry are thermally sensitive. Keeping devices of control circuitry inside of constant temperature environment is straightforward but needs lots of electronic and mechanic works. Instead, devices with low temperature coefficient were used, and it is independent to the efficiency of linear power supply. With this technology, correction power supplies have been modified and ±50 ppm long-term current stability has been reached.
Flat Photonics Using High Contrast Metastructures (2013)

A new class of planar optics has emerged using near-wavelength period gratings with a large refractive index contrast. This seemingly simple structure lends itself to extraordinary properties, which can be designed top-down based for integrated optics on a silicon substrate. In particular, the near-wavelength gratings with large index contrast wiht its surrounding materials are referred as high-contrast gratings (HCG). The extraordinary features include an ultra broadband (Δλ/λ&gt;30%) high reflectivity (&gt;99%) reflector for surface-normal incident light. Another feature is a high quality-factor resonance (Q&gt;107) with surface-normal emission. We incorporated HCG as a replacement of conventional distributed Bragg reflectors (DBR) in vertical cavity surface emitting lasers (VCSELs) over a wide wavelength range from 850-nm to 1550-nm. We also demonstrated high-Q cavity with surface-normal input/output beam using a single HCG layer. This resonator is formed without a Fabry-Perot cavity!
Assignment of an Ethertype for IPv6 with Low-Power Wireless Personal Area Network (LoWPAN) Encapsulation (2016)

When carried over Layer 2 technologies such as Ethernet, IPv6
datagrams using Low-Power Wireless Personal Area Network (LoWPAN)
encapsulation as defined in RFC 4944 must be identified so the
receiver can correctly interpret the encoded IPv6 datagram. The IETF
officially requested the assignment of an Ethertype for that purpose
and this document reports that assignment.
Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) Activity by the Aqueous Partition of Guava Leaf Extract (2018)

Guava leaf tea has been used as a folk medicine for treating hyperglycemic conditions in Asia and Africa. The hypoglycemic efficacy of guava leaf has been documented by many scientists in these regions, but the hypoglycemic mechanism is poorly understood. Guava leaves were extracted with methanol and the crude extract was partitioned against hexane, ethyl acetate, and butanol in sequence. The leftover in water is defined as the aqueous partition. A second smaller batch was extracted with hot water directly. Oral glucose tolerance test was carried out on healthy mice instead of diabetic mice that lack endogenous insulin. Glucose uptake was examined with 3T3-L1 adipocytes. Oxidative effect on PTP1B (protein tyrosine phosphatase 1b) was carried out with real-time PTP1B enzymatic assay. The aqueous partition of guava leaf extract possesses a potent inhibitory effect on PTP1B enzymatic activity and this PTP1B inhibition is through a slow oxidative but reversible inactivation on the enzyme. The reversible inactivation would suggest guava leaf extract may augment PTP1B inhibition alongside the endogenous H 2 O 2 which itself is induced by insulin. In addition, our study confirmed the hypoglycemic efficacy being associated with guava leaf and found the most effective molecules reside in the aqueous partition which is also less cytotoxic to Chinese hamster ovary cells when compared to other less polar partitions. The guava leaf extract can modulate insulin activity through a redox regulation on PP1B enzymatic activity. It is speculated that a compound similar to gallocatechin in the aqueous partition can reduce an oxygen molecule to hydrogen peroxide which in turn oxidizes the catalytic residue Cys in PTP1B. Therefore, the guava leaf tea can serve as a functional hypoglycemic drink that is suitable for either healthy or diabetic subjects.
Anodic Film Formation on AA 2099-T8 Aluminum Alloy in Tartaric–Sulfuric Acid (2010)

The anodizing behavior of a lithium-containing aluminum alloy (AA 2099-T8) in an environmentally friendly electrolyte, namely tartaric–sulfuric acid (TSA), has been examined under potentiodynamic and potentiostatic conditions. Specifically, the dependence of the anodic film morphology and composition on the anodizing voltage was investigated. It is revealed that porous anodic films with well-defined cells were formed at relatively low voltages while porous anodic films with pores of increased dimensions and lateral porosity were formed at increased voltages. In addition, it is indicated that copper in the alloy matrix can be occluded in the anodic film material as copper-rich nanoparticles or it can be oxidized and incorporated into the film material as copper ions, depending on the anodizing voltage. In the latter case, the process is accompanied by oxygen gas generation within the film material, resulting in the lateral porosity in the anodic film. Further, the structures of the copper-rich nanoparticles have been determined and the mechanism of the formation of such nanoparticles has been discussed.
Monte Carlo vs Molecular Dynamics for Conformational Sampling (1997)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionMonte Carlo vs Molecular Dynamics for Conformational SamplingWilliam L. Jorgensen and Julian Tirado-RivesCite this: J. Phys. Chem. A 1997, 101, 15, 2916Publication Date (Web):April 10, 1997Publication History Published online10 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/jp9702917https://doi.org/10.1021/jp9702917correctionACS PublicationsCopyright © 1997 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views381Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (12 KB) Get e-Alertsclose Get e-Alerts
A hybrid Japanese parser with hand-crafted grammar and statistics (2000)

This paper describes a hybrid parsing method for Japanese which uses both a hand-crafted grammar and a statistical technique. The key feature of our system is that in order to estimate likelihood for a parse tree, the system uses information taken from alternative partial parse trees generated by the grammar. This utilization of alternative trees enables us to construct a new statistical model called Triplet/Quadruplet Model. We show that this model can capture a certain tendency in Japanese syntactic structures and this point contributes to improvement of parsing accuracy on a shallow level. We report that, with an underspecified HPSG-based grammar and a maximum entropy estimation, our parser achieved high accuracy: 88.6% accuracy in dependency analysis of the EDR annotated corpus, and that it outperformed other purely statistical parsing methods on the same corpus. This result suggests that proper treatment of hand-crafted grammars can contribute to parsing accuracy on a shallow level.
A Demonstration Project on Driving with Reduced Visual Acuity and a Bioptic Telescope System in the Netherlands (2008)

Background: In Europe, driving a passenger car is prohibited if binocular best corrected visual acuity (BCVA) is below 0.5 (20/40). Some US states allow people with reduced visual acuity to use a bioptic telescope system when driving. The aim of our study is to introduce a bioptic telescope system for driving in the Netherlands and to investigate whether it enables people with reduced visual acuity to gain sufficient practical fitness to drive in a European setting. Results: Out of 378 persons who applied for information following media attention for the project, 160 candidates volunteered to participate. Based on the available information, 36 subjects (binocular BCVA: 0.16–0.5 [20/125–20/40]) were invited for assessment (vision, mobility, cognitive function, and driving skills). Of these, 16 did not meet the inclusion criteria and 2 decided not to participate. The remaining 18 subjects were trained in the use of a monocular bioptic telescope (3× magnification). They all completed the predriving training successfully and received driving lessons from specialized professional driving instructors. Eventually, 9 subjects passed the official on-road test of practical fitness to drive, 7 were excluded after a number of driving lessons, and another 2 withdrew on their own initiative. Conclusion: This is the first study in Europe to prepare subjects with reduced visual acuity to drive with the use of a bioptic telescope system. About 55% of the preselected subjects fulfilled all inclusion criteria. Half of the subjects who entered the bioptic training program passed the official fitness to drive test, demonstrating that they could drive smoothly and safely in Dutch traffic using a bioptic telescope system.
ChemInform Abstract: Expedient Synthesis of Substituted 4‐Hydroxy‐quinolin‐2(1H)‐ones. (2016)

Abstract A highly convergent synthesis of the title compounds is developed.
Modulation of Acute Myeloblastic Leukemia (AML) Cell Proliferation and Blast Colony Formation by Antisense Oligomer for IL-1 Beta Converting Enzyme (ICE) and IL-1 Receptor Antagonist (IL-1ra) (1995)

In the present study we investigated the effects of IL-1 antagonism on the autonomous growth of cells in acute myeloblastic leukemia (AML). To examine the role of pro-IL-1 processing, antisense technology was employed with 16-mer phosphorothioate oligodeoxynucleotide directed against human IL-1 beta converting enzyme (ICR) in 7 randomly selected AML cases. The addition of 10-75 microM of antisense oligonucleotide (but not of control oligonucleotide) significantly inhibited spontaneous proliferation of bone marrow- (BM) and peripheral blood- (PB) derived low density leukemic cells in a dose-dependent way. Similarly, spontaneous as well as induced CFU-AML colony formation was inhibited by human ICE antisense oligonucleotide with sample-to-sample variability. In separate experiments, in order to examine the effects of blockade of endogenously produced IL-1 to IL-1 receptors, the functional activity of human recombinant IL-1 receptor antagonist (IL-1ra) was tested. Continuous exposure to high concentrations of IL-1ra (up to 100 micrograms/ml) produced dose-dependent inhibition of spontaneous proliferation of the BM-derived blast cells from 9 of the 14 patients and of the PB-derived cells from 10 of the 14 patients. However, in some of these patients, the lower IL-1ra doses (down to 100 ng/ml) induced potentiation of spontaneous proliferation, suggesting a novel regulatory pathway for IL-1 receptor engagement. Similar results were obtained on CFU-AML colony formation, showing inhibition at higher IL-1ra doses, but in a few AML cases stimulatory effect at lower IL-1ra doses.(ABSTRACT TRUNCATED AT 250 WORDS)
Radiosynthesis of [5‐[11C]methanesulfonyl‐2‐((S)‐2,2,2‐trifluoro‐1‐methyl‐ethoxy)‐phenyl]‐[5‐(tetrahydro‐pyran‐4‐yl)‐1,3‐dihydro‐isoindol‐2‐yl]‐methanone ([11C]RO5013853), a novel PET tracer for the glycine transporter type I (GlyT1) (2011)

The glycine transporter type 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. We have recently discovered and developed [ 11 C]RO5013853 as a novel positron emission tomography tracer for GlyT1 for which a reliable five‐step synthetic route was established. The incorporation of the radioisotope was achieved in the final step through methylation of a sodium sulfinate precursor, itself easily accessible upon reduction of the corresponding sulfonyl‐chloride analog. [ 11 C]RO5013853 was prepared with high specific activity (&gt;49 GBq/µmol) and high radiochemical purity (100%). A validation study of [ 11 C]RO5013853 in animal imaging studies is in progress. Copyright © 2011 John Wiley &amp; Sons, Ltd.
Legends for supplmentary figures from Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma (2023)

&lt;p&gt;Figure S1. Expression and localization of ILK protein and EMT-related molecular markers in normal renal epithelial cells and RCC cells. Figure S2. Anti-angiogenic effects of in vivo knockdown of ILK in orthotopic RCC xenografts.&lt;/p&gt;