gebhart/patrepeval huggingface dataset:
Summary report on enterprise security workshop (2000)

This report summarizes the presentations of the 6th IEEE Enterprise Security Workshop. The workshop included twenty presentations, one invited talk and on discussion session. The presentations are divided into the following categories, representing a broad range of topics: Intrusion detection and system security; Access control, Anonymity, Environment and frameworks, Key recovery, Key management and protocols, Privacy and law. The invited talk was given by Distinguished Engineer of Sun Microsystems, Radia Perlman, on the topic of IPSec key exchange standards. A lively discussion session was organized by program co-chair Germano Carroni on the topic of future of firewall. In this report, we intend to highlight interesting and provocative topics that generated the most discussions in each session. We hope it serves as thought provoking questions that are seeking answers from the readers. In addition, we hope this summary report can be used to provide some additional information for the readers when reading the technical papers. The titles and authors of the presented papers are not repeated in the following summary. The reader is advised to refer to the presentation agenda which can be found at the WETICE 2001 website.
Chemical consequences of orbital interactions in hydrocarbons containing unsaturativety bridged small rings (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical consequences of orbital interactions in hydrocarbons containing unsaturativety bridged small ringsWilliam L. Jorgensen and Weston T. BordenCite this: J. Am. Chem. Soc. 1973, 95, 20, 6649–6654Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00801a021https://doi.org/10.1021/ja00801a021research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates (2010)

The assembly of double-stranded (ds) DNA nanocircles both by hybridization with branched oligodeoxynucleotides (ODNs) and by intercalation was analyzed by atomic force microscopy (AFM). Branched ODNs ligated to single-stranded (ss) gap regions of dsDNA nanocircles led to defined, dumbbell-shaped architectures. ODNs containing an aromatic intercalator yielded oligomeric aggregates.
Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population (2001)

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation. It is most likely the result of complex interactions of environmental and genetic factors. Because pulmonary surfactant components play important roles in normal lung function, innate host defence, and inflammation in the lung, this study investigated the hypothesis that the surfactant protein genes are involved in certain cases of COPD. Genotype analysis of surfactant protein (SP)-A, SP-B, SP-B-linked microsatellite, and SP-D marker alleles was performed in patients with COPD (n=97) and smoker (n=82) or nonsmoker (n=99) controls. Univariate and multiple logistic regression analyses were performed. The regression analysis results between COPD and smokers revealed several COPD susceptibility alleles (AA62_A, B1580_C, D2S388_5), based on an odds ratio (OR >2.5). The predictive ability of this model for developing COPD is good (c=0.926). Allele-allele (B1580_C and D2S388_5) and allele-environment (i.e. smoking) interactions were detected. When smoker controls were compared to nonsmoker controls, marker D2S388 5 appeared to be smoking-independent (p=0.874), whereas marker alleles AA62_A (p=0.045) and B1580_5 (p=0.007) were smoking-dependent. Males were at higher risk (OR=6.05, p=0.001), and smoking (>50 packs x yr(-1)) increased risk (OR=5.38, p=0.007). Males and alleles of loci flanking SP-B were associated with more severe cases (forced expiratory volume in one second/forced vital capacity < or = 40%). The present results indicate that the surfactant protein alleles may be useful in chronic obstructive pulmonary disease by either predicting the disease in a subgroup and/or by identifying disease subgroups that may be used for therapeutic intervention. These observations should now be confirmed in a larger study, designed according to strict epidemiological criteria.
Structure Activity Relationship of Kahalalide F and its Analogs Against Fusarium Spp (2008)

Kahalalide F (1) is a depsipeptide isolated from the Hawaiian herbivorous marine sacoglossan mollusk Elysia rufescens (Plakobranchidea) and its green algal diet of Bryopsis pennata (Bryopsidaceae). Modification of Kahalalide F on acetylation and oxidation of the secondary alcohol group of threonine, as well as reductive alkylation of the primary amine function of ornithine improved the activity as antifungal agent particularly against filamentous fungi Fusarium spp. which represents an opportunistic infection in humans and phytopathogen. Acknowledgements: This work was supported by National Institute of Health (NIAID) 1RO1AI36596, CDC and NOAA. This investigation was conducted in a facility constructed with support from Research Facilities Improvements Program (C06 RR-14503-01) from the National Center for Research Resources, NIH. Antimicrobial testing was supported by the NIH, NIAID, division of AIDS, grant No. AI 27094, and the USDA Agricultural Research Service Specific Cooperative Agreement No. 58-6408-2-0009. References: [1] Shilabin AG, et al. (2007) J. Med. Chem. 50: 4340–4350. [2] Hamann MT, Scheuer PJ (1993) J. Am. Chem. Soc. 115: 5825–5826. [3] Hamann MT, et al. (1996) J. Org. Chem. 61: 6594–6600.
Adaptation method for video streaming over HTTP/2 (2016)

HTTP streaming, which is currently based on the pull-based HTTP/1.1 protocol, has a tradeoff problem between overhead and adaptivity. We propose an adaptation method for adaptive streaming over the new HTTP/2 protocol, leveraging its server push feature. The method is based on a cost function that takes into account the number of pushed segments and the client buffer level. Experiment results show that the proposed method can improve the balance between the number of requests and buffer stability compared to existing methods.
Monoclonal Antibodies Specific for Peptide Epitopes of the Epidermal Growth Factor Receptor's Extracellular Domain (1997)

The ErbB tyrosine kinase receptor family plays an important role in normal cellular growth and differentiation. In addition, ErbB receptor family members are commonly amplified and overexpressed in various human neoplasms and tumor-derived cell lines, where it is believed that increased signalling as a result of receptor overexpression may play an important role in oncogenesis. Consequently, ErbB receptor family members are being investigated rigorously as potential biomarkers of cancer and as therapeutic targets in malignant tissues. Numerous studies now demonstrate the existence of "soluble" ErbB (sErbB) analogs in normal and cancerous tissues. These sErbB proteins embody the extracellular domain (ECD) of the receptor only; they are generated by either proteolytic cleavage or from truncated, alternatively spliced mRNA transcripts. Recently, we have identified an alternate transcript of the human c-erbB1 (Epidermal Growth Factor Receptor) proto-oncogene from placenta that encodes a sErbB1 protein of 60-kDa. This protein, p60 sErbB1, is glycosylated and secreted when expressed in transfected tissue culture cells in vitro. Although "soluble" receptor analogs may play important physiological roles in intercellular communication, tissue morphogenesis, tissue regeneration and repair, and embryogenesis by inhibiting or stimulating specific mitogenic and pattern forming signals, their mechanism of action has not been thoroughly elucidated. To further characterize sErbB1 expression in human tissues and cell lines and to better understand their role in carcinogenesis and normal development, we have generated monoclonal antibodies (MAbs) toward specific peptide epitopes of ErbB1 extracellular subdomains III and IV. These antibody reagents are described here and should be useful experimental, preparative, analytical, diagnostic, and therapeutic reagents for the study of sErbB1 molecules in normal development and cancer.
Continuous injection synthesis of indium arsenide quantum dots emissive in the short-wavelength infrared (2016)

Abstract With the emergence of applications based on short-wavelength infrared light, indium arsenide quantum dots are promising candidates to address existing shortcomings of other infrared-emissive nanomaterials. However, III–V quantum dots have historically struggled to match the high-quality optical properties of II–VI quantum dots. Here we present an extensive investigation of the kinetics that govern indium arsenide nanocrystal growth. Based on these insights, we design a synthesis of large indium arsenide quantum dots with narrow emission linewidths. We further synthesize indium arsenide-based core-shell-shell nanocrystals with quantum yields up to 82% and improved photo- and long-term storage stability. We then demonstrate non-invasive through-skull fluorescence imaging of the brain vasculature of murine models, and show that our probes exhibit 2–3 orders of magnitude higher quantum yields than commonly employed infrared emitters across the entire infrared camera sensitivity range. We anticipate that these probes will not only enable new biomedical imaging applications, but also improved infrared nanocrystal-LEDs and photon-upconversion technology.
Acetylcholine and Bradykinin Relax Intrapulmonary Arteries by Acting on Endothelial Cells: Role in Lung Vascular Diseases (1981)

Acetylcholine and bradykinin produced potent relaxation of isolated canine intrapulmonary arteries contracted by serotonin, norepinephrine, or phenylephrine-provided the endothelium was left intact. Selective mechanical destruction of the endothelium transformed the activity of these substances from vasodilatation to vasoconstriction. Acetylcholine-induced relaxations, in the presence of intact endothelium, could be selectively inhibited competitively by atropine, but could not be inhibited by cyclooxygenase inhibitors, a lipoxygenase inhibitor, adrenergic blocking drugs, or histaminergic antagonists. RElaxations produced by prostacyclin, prostaglandin E1, isoproterenol, papaverine, or histamine H2-receptor agonists were not modified, or attenuated, by selective destruction of pulmonary endothelial cells. These observations might provide insight into the etiology of the increased pulmonary resistance observed in pulmonary hypertension and shock lung.
Image to Image Translation for Domain Adaptation (2017)

We propose a general framework for unsupervised domain adaptation, which allows deep neural networks trained on a source domain to be tested on a different target domain without requiring any training annotations in the target domain. This is achieved by adding extra networks and losses that help regularize the features extracted by the backbone encoder network. To this end we propose the novel use of the recently proposed unpaired image-toimage translation framework to constrain the features extracted by the encoder network. Specifically, we require that the features extracted are able to reconstruct the images in both domains. In addition we require that the distribution of features extracted from images in the two domains are indistinguishable. Many recent works can be seen as specific cases of our general framework. We apply our method for domain adaptation between MNIST, USPS, and SVHN datasets, and Amazon, Webcam and DSLR Office datasets in classification tasks, and also between GTA5 and Cityscapes datasets for a segmentation task. We demonstrate state of the art performance on each of these datasets.
Data from Phase I Clinical Trial of Selinexor in Combination with Daunorubicin and Cytarabine in Previously Untreated Poor-Risk Acute Myeloid Leukemia (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Induction chemotherapy results in complete remission (CR) rates of 20% to 50% among patients with poor-risk AML. Selinexor is an oral selective inhibitor of nuclear export with promising single-agent activity. By inhibiting the primary export protein, XPO1, selinexor localizes and activates tumor suppressor proteins in the nucleus and inhibits DNA damage repair, rationalizing combination with DNA-damaging agents.&lt;/p&gt;Patients and Methods:&lt;p&gt;This was a single-arm phase I clinical trial of selinexor combined with cytarabine and daunorubicin (7+3). Dose escalation was selinexor alone (3+3) with an expansion at the MTD. Cohorts 1 and 2 received 60 and 80 mg orally, respectively, twice weekly during induction. Consolidation cycles (≤ 2) with selinexor at induction dose plus 5+2 were allowed for patients who achieved CR. MTD and recommended phase II dose of selinexor were the primary endpoints.&lt;/p&gt;Results:&lt;p&gt;Twenty-one patients with poor-risk AML were enrolled. All 21 patients were included in the safety evaluations and survival analyses (4 in each of 2 cohorts; 13 in the expansion); 8 (53%) of the 19 patients evaluable for response achieved CR/CRi. MTD was not reached. Selinexor 80 mg (orally, twice weekly) was used in the expansion phase. The most common grade 3/4 nonhematologic treatment-emergent adverse events were febrile neutropenia (67%), diarrhea (29%), hyponatremia (29%), and sepsis (14%). At median follow-up (28.9 months), 38% of patients were alive. Median overall survival was 10.3 months.&lt;/p&gt;Conclusions:&lt;p&gt;Selinexor plus 7+3 is a safe regimen for patients with newly diagnosed poor-risk AML and warrants further investigation in a larger clinical trial.&lt;/p&gt;&lt;/div&gt;
Collision-induced IR absorption in gas phase Hg(6 3P1)+HgBr2(1 1Σ+g) reactions: Enhancement of the HgBr(B 2Σ+) product channel (1985)

We have investigated laser-assisted reactions in Hg/HgBr2 gas mixtures by measuring fluorescence from the product, HgBr radical, following simultaneous IR (1064 nm) and UV (253.7 nm) laser excitation. The product emission has one-photon dependence on both IR and UV laser power, and the results indicate that the excited HgBr product channel is accessed through single photon absorptions by the {Hg–HgBr2} complex. This constitutes the first experimental evidence for an electronically excited state of the {Hg–HgBr2} collision complex, having an energy level &amp;gt;4.9 eV but &amp;lt;6.1 eV. With the addition of tunable IR lasers this technique could provide an important spectroscopic method for investigation of the homologous series of collision complexes, {Hg–HgX2} where (X=F, Cl, Br, I).
Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. (2000)

Pulmonary inflammatory and hematologic responses of canines were studied after exposure to concentrated ambient particles (CAPs) using the Harvard ambient particle concentrator (HAPC). For pulmonary inflammatory studies, normal dogs were exposed in pairs to either CAPs or filtered air (paired studies) for 6 hr/day on 3 consecutive days. For hematologic studies, dogs were exposed for 6 hr/day for 3 consecutive days with one receiving CAPs while the other was simultaneously exposed to filtered air; crossover of exposure took place the following week (crossover studies). Physicochemical characterization of CAPs exposure samples included measurements of particle mass, size distribution, and composition. No statistical differences in biologic responses were found when all CAPs and all sham exposures were compared. However, the variability in biologic response was considerably higher with CAPs exposure. Subsequent exploratory graphical analyses and mixed linear regression analyses suggested associations between CAPs constituents and biologic responses. Factor analysis was applied to the compositional data from paired and crossover experiments to determine elements consistently associated with each other in CAPs samples. In paired experiments, four factors were identified; in crossover studies, a total of six factors were observed. Bronchoalveolar lavage (BAL) and hematologic data were regressed on the factor scores. Increased BAL neutrophil percentage, total peripheral white blood cell (WBC) counts, circulating neutrophils, and circulating lymphocytes were associated with increases in the aluminum/silicon factor. Increased circulating neutrophils and increased BAL macrophages were associated with the vanadium/nickel factor. Increased BAL neutrophils were associated with the bromine/lead factor when only the compositional data from the third day of CAPs exposure were used. Significant decreases in red blood cell counts and hemoglobin levels were correlated with the sulfur factor. BAL or hematologic parameters were not associated with increases in total CAPs mass concentration. These data suggest that CAPs inhalation is associated with subtle alterations in pulmonary and systemic cell profiles, and specific components of CAPs may be responsible for these biologic responses.
Hyperion Flying Wing Aircraft Technology Poster Presentation (2011)

Student engineering teams develop a 3m scale model inspired after the NASA-Boeing X-48B blended wing body to use as a test bed for advanced technical studies. The design concept, named Hyperion, implements a novel hybrid gas/electric power train as a green aircraft technology. The aircraft serves as a test-bed for research and development in the following focus areas: aerodynamics, structures and materials, weights and mass properties, handling and control, flight mechanics, and efficiency improvements on performance. The University of Colorado’s collaboration with the University of Stuttgart, Germany, and the University of Sydney, Australia, allows the global project team to work full 24-hour days on the project by transitioning every 8 hours. Thus, the project teaches essential global industry skills in project management and systems engineering through long-distance design collaboration with multidisciplinary and multicultural teams of graduate and undergraduate students located around the world. Lessons learned will be valuable for the students and industry.
Hydrochloride Salt of the GABAkine KRM-II-81 (2022)

Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4<i>H</i>-benzo[<i>f</i>]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABA<sub>A</sub> receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many seizure and pain models in rodents, where it exhibits improved pharmacological properties over standard-of-care agents. Since salts can be utilized to create opportunities for increased solubility, enhanced absorption, and distribution, as well as for efficient methods of bulk synthesis, a hydrochloride salt of KRM-II-81 was prepared. KRM-II-81·HCl was produced from the free base with anhydrous hydrochloric acid. The formation of the monohydrochloride salt was confirmed by X-ray crystallography, as well as <sup>1</sup>H NMR and <sup>13</sup>C NMR analyses. High water solubility and a lower partition coefficient (octanol/water) were exhibited by KRM-II-81·HCl as compared to the free base. Oral administration of either KRM-II-81·HCl or the free base resulted in high concentrations in the brain and plasma of rats. Oral dosing in mice significantly increased the latency to both clonic and tonic convulsions and decreased pentylenetetrazol-induced lethality. The increased water solubility of the HCl salt enables intravenous dosing and the potential for higher concentration formulations compared with the free base without impacting anticonvulsant potency. Thus, KRM-II-81·HCl adds an important new compound to facilitate the development of these imidazodiazepines for clinical evaluation.
Methodology of Mobile Computing in Construction Management (2004)

Methodology of Mobile Computing in Construction Management Kenji Kimoto, Mitsuhiro Fujiwara, Takahiro Kataoka, Shuichi Matsumura, Kazuyoshi Endo Abstract: This paper reports the development of mobile computing in construction management. The paper focuses on the methodology of the development based on EUC. First, the paper indicates the effectiveness of EUC in construction projects. The authors introduce design pattern of user interface and the use of UML for EUC. Secondly, the paper describes the process of development of PDA Inspection Support System for Finish Work with UML. User interface is an interface between users and computer-aided system, and can be one between users and system developers. In the developed system, user interfaces are classified to some design patterns with the use of control function such as list, option button and scroll bar. End users can customize and combine them freely. As a result, they can make their own flowcharts. System developers can build computer-aided systems with them easily and quickly. The paper also shows the effectiveness of the system. Finally, the paper summarizes this methodology and concludes the effectiveness. Keywords: Construction Management, Mobile Computing, PDA (Personal Digital Assistants), EUC (End User Computing), Design Pattern, UML (Unified Modeling Language) DOI: https://doi.org/10.22260/ISARC2004/0099 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
The Heavy-Duty Gasoline Engine - An Alternative to Meet Emissions Standards of Tomorrow (2004)

&lt;div class="htmlview paragraph"&gt;A technology path has been identified for development of a high efficiency, durable, gasoline engine, targeted at achieving performance and emissions levels necessary to meet heavy-duty, on-road standards of the foreseeable future. Initial experimental and numerical results for the proposed technology concept are presented. This work summarizes internal research efforts conducted at Southwest Research Institute.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;An alternative combustion system has been numerically and experimentally examined. The engine utilizes gasoline as the fuel, with a combination of enabling technologies to provide high efficiency operation at ultra-low emissions levels. The concept is based upon very highly-dilute combustion of gasoline at high compression ratio and boost levels. Results from the experimental program have demonstrated engine-out NO&lt;sub&gt;x&lt;/sub&gt; emissions of 0.06 g/hp/hr, at single-cylinder brake thermal efficiencies (BTE) above thirty-four percent. Multi-cylinder, 3-way catalyst equipped versions of this engine are estimated to provide NO&lt;sub&gt;x&lt;/sub&gt;emissions of approximately 0.003 g/hp/hr at efficiencies approaching thirty-nine percent.&lt;/div&gt;
High-power polarization-maintaining dispersion-shifted EDFA (1996)

Summary form only given. We have developed fully engineered polarization-maintaining and dispersion-shifted Er-doped fiber amplifiers (EDFAs) using polarization-maintaining and absorption-reducing (PANDA) and dispersion shifted fiber structure erbium-doped fiber (PMDS-EDF).