gebhart/patrepeval huggingface dataset:
Hematopoietic Progenitor Cell Mobilization in Mice by Sustained Delivery of Granulocyte Colony-Stimulating Factor (2005)

The objective of these studies was to determine the effect of sustained delivery of growth factors (GFs) on hematopoietic progenitor cells (HPCs) in mice. In these studies, granulocyte colony-stimulating factor (G-CSF) was administered using the poloxamer-based matrix, ProGelz (PG) and G-CSF, and pharmacokinetics (PKs) and HPC mobilization was assessed. A single injection of G-CSF formulated in PG (17% poloxamer-407 and 5% hydroxypropyl methylcellulose [HPMC]) administered to BALB/c mice mobilized HPC significantly more rapidly to the spleen, but not the blood, than multiple injections of saline-formulated G-CSF. Two days after a single injection of PG G-CSF, the frequency of colony-forming unit-culture (CFU-c) in the spleen was increased 289-fold compared with an 8-fold increase after 2 days of twice-daily injections of saline-formulated G-CSF. Indeed, 4 days of twice-daily G-CSF injections were required to achieve the same level of HPC mobilization. In contrast, a similar mobilization of HPC to the blood was observed between PG and saline-formulated G-CSF. The mechanism for the accelerated and increased mobilization to the spleen by the PG-formulation of G-CSF is due, in part, to its increased bioavailability (>1.5-fold), T(max) (6-fold), and prolonged elimination (Tbeta) half-life (>3-fold) as compared with a saline formulation. In addition, we observed a more rapid trafficking of the PG G-CSF to the marrow, which could also facilitate mobilization.
A new strategy for the Lewis acid-catalyzed cyclopropanation of allylic alcohols. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new strategy for the Lewis acid-catalyzed cyclopropanation of allylic alcohols.Andre B. Charette and Christian BrochuCite this: J. Am. Chem. Soc. 1995, 117, 45, 11367–11368Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00150a046https://doi.org/10.1021/ja00150a046research-articleACS PublicationsRequest reuse permissionsArticle Views1067Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A note on stochastic decomposition in a GI/G/1 queue with vacations or set-up times (1985)

In this note we prove some stochastic decomposition results for variations of the GI / G /1 queue. Our main model is a GI / G /1 queue in which the server, when it becomes idle, goes on a vacation for a random length of time. On return from vacation, if it finds customers waiting, then it starts serving the first customer in the queue. Otherwise it takes another vacation and so on. Under fairly general conditions the waiting time of an arbitrary customer, in steady state, is distributed as the sum of two independent random variables: one corresponding to the waiting time without vacations and the other to the stationary forward recurrence time of the vacation. This extends the decomposition result of Gelenbe and Iasnogorodski [5]. We use sample path arguments, which are also used to prove stochastic decomposition in a GI / G /1 queue with set-up time.
A benchmark for 3D mesh segmentation (2009)

This paper describes a benchmark for evaluation of 3D mesh segmentation salgorithms. The benchmark comprises a data set with 4,300 manually generated segmentations for 380 surface meshes of 19 different object categories, and it includes software for analyzing 11 geometric properties of segmentations and producing 4 quantitative metrics for comparison of segmentations. The paper investigates the design decisions made in building the benchmark, analyzes properties of human-generated and computer-generated segmentations, and provides quantitative comparisons of 7 recently published mesh segmentation algorithms. Our results suggest that people are remarkably consistent in the way that they segment most 3D surface meshes, that no one automatic segmentation algorithm is better than the others for all types of objects, and that algorithms based on non-local shape features seem to produce segmentations that most closely resemble ones made by humans.
Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites (2016)

A collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6')-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.
Synthetic and Spectroscopic Study of the Mechanism of Atomic Layer Deposition of Tin Dioxide (2016)

This study details the surface reaction chemistry relevant to the vapor deposition mechanism of SnO2 thin films by atomic layer deposition. The mechanism was elucidated by combining different spectroscopic studies. Initial nucleation of cyclic N2,N3-di-tert-butylbutane-2,3-diamidotin(II) (1) consists of surface SiOH protonation of ligands as shown by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). This SiO2-surface-bound stannylene was further characterized by X-ray absorption (XAS) and resonance Raman spectroscopy. XAS, DRIFTS, and Raman spectroscopy were then used to follow the further reaction of the surface-bound stannylene with different oxygen sources and a second equivalent of 1. It was observed that water does not oxidize the initial surface-bound tin site, and a well-defined, three-coordinate tin(II) species, with two surface oxygen bonds and one coordinated water molecule, was characterized. Treatment of the surface stannylene with protic oxidants such as H2O2 or tBuOOH fully oxidizes tin to 4+, and coordination of additional oxygen ligands is observed. When a second equivalent of 1 is added to surface-bound Sn4+, the resulting surface tin is also found to be in the 4+ oxidation state, contrary to the nonoxidative nucleation step. As such, surface peroxide species provide a probable growth mechanism of SnO2 through oxidation, while nucleation occurs through protic ligand exchange.
Compatibility and viscoelastic properties of brominated isobutylene‐co‐p‐methylstyrene rubber/tackifier blends (2008)

Abstract Brominated isobutylene‐ co‐p ‐methylstyrene (BIMS) rubber has been blended with hydrocarbon resin tackifier and alkyl phenol formaldehyde resin tackifier, and the compatibility between the blend components has been systematically evaluated. Dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) studies show that BIMS rubber and hydrocarbon resin tackifier blends are compatible at all blend proportions studied. However, BIMS rubber and phenol formaldehyde resin blends exhibit very limited compatibility with each other and phase separation even at very low phenolic tackifier concentration. Morphological studies of the rubber–resin blends by scanning electron microscopy (SEM) corroborate well with the DMA and DSC results. From the DMA frequency sweep and temperature sweep studies, it is shown that the hydrocarbon resin tackifier acts as a diluent and causes a decrease in the storage modulus values (by reducing the entanglement and network density) in the rubbery plateau region. On the other hand, phenol formaldehyde resin behaves in the way similar to that of the reinforcing filler by increasing the storage modulus values (by increasing the entanglement and network density) in the rubbery plateau zone. The relaxation time estimated from the different zones of frequency sweep master curves provides information about the influence of the two tackifiers on the viscoelastic properties of the BIMS rubber in the respective zones. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
What Are the Characteristics of Caregivers Logging in for Support Services? (2019)

Based on differences in the characteristics of caregivers using different service delivery modes and the low uptake of online-delivered services, we suggest online service delivery should supplement, not replace, usual delivery modes in social service settings. At the same time, user rates of online service delivery are likely modifiable. Given the potential for online-delivered programming to expand access to information services for caregivers, we recommend further examination into the effects of marketing online service delivery options to caregivers in novel ways.
Small cell carcinoma of the lung presenting as chylous ascites: a unique case. (1997)

A 67-year-old female presenting with a history of weight loss and abdominal distension was noted on examination to have ascites. Paracentesis revealed a chylous ascites and chest radiography showed a right hilar enlargement with mid-zone infiltration. Abdominal computed tomography demonstrated retroperitoneal lymphadenopathy and biopsy of this showed small cell undifferentiated carcinoma. This appears to be the first documented association between metastatic small cell carcinoma of the lung and chylous ascites.
[P3–378]: FIRST‐IN‐HUMAN PET STUDY WITH 18F‐AM‐PBB3 AND 18F‐PM‐PBB3 (2017)

Recent advancements of novel tau positron emission tomography (PET) ligands are shedding light on the nature of diverse tauopathies, such as Alzheimer's disease (AD), primary age-related tauopathy (PART), progressive nuclear palsy (PSP), corticobasal degeneration (CBD). Affinity and selectivity for distinct tau pathologies vary among diverse ligands. Our previous studies demonstrated that 11C-pyridinylbutadienyl-benzothiazole 3 (11C-PBB3) can detect a broad range of tau inclusions. However, there are several technical issue on the use of 11C-PBB3, including a relatively short half-life of 11C, limited dynamic range, metabolic instability and off-target binding in the basal ganglia and thalamus, hampering is wider use and application to early detection of tau pathologies especially in PSP and CBD. To overcome these drawbacks of 11C-PBB3, we developed novel PBB3 derivatives, 18F-AM-PBB3 and 18F-PM-PBB3. The present study aims to investigate characteristics of in vivoPET imaging of these fluorinated tau radioligands. A small-scale clinical PET study with 18F-AM-PBB3 or 18F-PM-PBB3 was performed for AD and age-matched cognitive healthy control (HC) subjects. Arterial blood sampling and free fraction measurements were performed after injection of 18F-AM-PBB3 and 18F-PM-PBB3. 11C-PBB3 and 11C-PiB PET scans were also performed within one month. Parametric images of standardized uptake value ratio (SUVR) to the cerebellar cortex were generated for all radioligands on a voxel-by-voxel basis. Dynamic ranges of 18F-AM-PBB3 and 18F-PM-PBB3 for detection of AD tau lesions were about 1.5- and 2-fold higher, respectively, than that of 11C-PBB3. Regional distribution of specific binding was similar among these three ligands. Off-target binding of 11C-PBB3 was noticeable in the basal ganglia and thalamus, while 18F-AM-PBB3 and 18F-PM-PBB3 showed no prominent off-target signals in these regions. Binding to choroid plexus was conspicuous in 18F-PM-PBB3 and slightly noticeable in 18F-AM-PBB3, while 11C-PBB showed little off-target binding in this structure. This study demonstrated that fluorinated PBB3 derivatives showed regional distribution of specific binding similar to 11C-PBB3, and broader dynamic range and less off-target binding to the basal ganglia and thalamus than 11C-PBB3. These findings support the potential utility of fluorinated PBB3 derivatives in non-AD tauopathies, which is currently being examined.
Meeting the Insulation Requirements of the Building Envelope with Polyurethane and Polyisocyanurate Foam (2004)

The use of insulating products in the building envelope is defined by many criteria. The specified R-value or k-factor for the structure is an essential component of most specifications. The industry has traditionally reported the R-value measured at a mean temperature of 75°F for use to calculate insulation requirements for the building envelope. With improvements in instrumentation, it is now possible to specify insulation based upon the actual use temperatures for a given building or region. This paper compares the performance of insulating products over a variety of mean temperature ranges including a discussion of measurement methods.
NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis (1991)

Rats received a unilateral lesion of the nucleus basalis by infusion of ibotenic acid. Two weeks after the lesion, osmotic minipumps were implanted, that infused 1 microgram human recombinant nerve growth factor (NGF) or cytochrome-C per day into the lateral ventricle. After four weeks of treatment, release of acetylcholine was measured in the frontal neocortex by means of in-vivo microdialysis. Release was decreased by 75% on the lesioned side; perfusion with 100 mM KCl increased release on the intact side by 130% and on the lesioned side by 80%. Treatment with NGF increased release on the lesioned side twofold, but had no effect on release on the intact side.
VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer. (2013)

In this rapidly accrued study, docetaxel and carboplatin were well-tolerated in the adjuvant treatment of NSCLC. Adjuvant treatment compliance was higher among patients undergoing a minimally invasive surgical approach. (ClinicalTrials.gov number NCT00883675).
Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride (2019)

Herein, we report the radiosynthesis of <sup>18</sup>F-difluoromethylarenes <i>via</i> the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [<sup>18</sup>F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated <sup>18</sup>F-fluorodecarboxylation.
Discriminating the biological motion of animals (2010)

Research into biological motion perception has revealed that the human visual system is sensitive to the movement patterns created by both humans and non-human animals when locomoting. In order to further assess the ability of the human visual system to detect the biological motion of animals with different locomotory patterns, observers were required to discriminate between point light displays depicting an animal in motion and point light displays containing dots moving in ways constrained by the properties present in the biological motion displays, but containing no biological motion themselves. Initial results indicated that naïve subjects could accurately discriminate between the displays containing biological motion and those containing motion of a non-biological nature. In order to assess this effect further, a second experiment was carried out to investigate the ability of naïve observers to discriminate between biological and non-biological point light displays as a) a function of random punctate visual interference density and b) a function of stimulus duration. To allow further investigation into how biological motion information concerning animals might be utilised by the visual system in naturalistic situations, subjects were tested for simple animal phobias in order to assess whether those subjects with a high fear of certain target animals (snakes and spiders, chosen for the sake of general prevalence of fear) would be able to distinguish the target animal from non-biological trials in the presence of a) greater density of noise and b) shorter stimulus duration. Results indicated that noise density had a significant effect on discrimination performance for both groups even at the lowest level.
In-Situ Observations of Phase Transformations in the HAZ of 2205 Duplex Stainless Steel Weldments (2001)

Ferrite ({delta})/austenite ({gamma}) transformations in the heat affected zone (HAZ) of a gas tungsten arc (GTA) weld in 2205 duplex stainless steel are observed in real-time using spatially resolved X-ray diffraction (SRXRD) with high intensity synchrotron radiation. A map showing the locations of the {delta} and {gamma} phases with respect to the calculated weld pool dimensions has been constructed from a series of SRXRD scans. Regions of liquid, completely transformed {gamma}, a combination of partially transformed {gamma} with untransformed {delta}, and untransformed {delta}+{gamma} are identified. Analysis of each SRXRD pattern provides a semi-quantitative definition of both the {delta}/{gamma} phase balance and the extent of annealing which are mapped for the first time with respect to the calculated weld pool size and shape. A combination of these analyses provides a unique real-time description of the progression of phase transformations in the HAZ. Using these real-time observations, important kinetic information about the transformations occurring in duplex stainless steels during heating and cooling cycles typical of welding can be determined.
<title>Vacuum maintenance in hermetically sealed MEMs packages</title> (1998)

Packages for many high sensitivity MEM devices (Micro- Electro-Mechanical devices) such as accelerometers need to operate in a vacuum in order to obtain their full performance. This vacuum is destroyed by the outgassing of species such as hydrogen and water vapor from the surfaces of the package exposed to this vacuum. To control this outgassing a getter is needed. MEM packages are too small to accommodate traditional sintered porous getters. A solution has been developed using a high porosity thick film getter material. The getter consists of a highly porous, mechanically stable, getter coating on a metal substrate. This getter reacts with active gases such as water vapor, hydrogen, oxygen, nitrogen, and carbon monoxide that outgas from the inner surfaces of the package. The physical characteristics and performance of this material will be demonstrated per ASTM sorption testing. The results of this testing will be used to demonstrate the potential for vacuum performance in a real world MEM package.
Development of Environmentally Friendly Self-Extinguishing Epoxy Resin Compound and Its Application to Electronic Devices (2005)

環境負荷の大きいハロゲン系などの難燃剤を一切添加せずに,自己消火機能をもつ難燃性エポキシ樹脂組成物を開発し,ICモールド材やプリント基板用絶縁材に適用した。この自己消火性エポキシ樹脂組成物は主として,ノボラック構造中に芳香族化合物をもつフェノールアラルキル型のエポキシ樹脂と硬化剤からなり,着火時に樹脂表面が発泡することで高度な難燃性を実現している。
High-Responsivity Graphene/InAs Nanowire Heterojunction Near-Infrared Photodetectors with Distinct Photocurrent On/Off Ratios (2014)

Graphene is a promising candidate material for high-speed and ultra-broadband photodetectors. However, graphene-based photodetectors suffer from low photoreponsivity and I(light)/I(dark) ratios due to their negligible-gap nature and small optical absorption. Here, a new type of graphene/InAs nanowire (NW) vertically stacked heterojunction infrared photodetector is reported, with a large photoresponsivity of 0.5 AW(-1) and I(light)/I(dark) ratio of 5 × 10(2), while the photoresponsivity and I(light)/I(dark) ratio of graphene infrared photodetectors are 0.1 mAW(-1) and 1, respectively. The Fermi level (E(F)) of graphene can be widely tuned by the gate voltage owing to its 2D nature. As a result, the back-gated bias can modulate the Schottky barrier (SB) height at the interface between graphene and InAs NWs. Simulations further demonstrate the rectification behavior of graphene/InAs NW heterojunctions and the tunable SB controls charge transport across the vertically stacked heterostructure. The results address key challenges for graphene-based infrared detectors, and are promising for the development of graphene electronic and optoelectronic applications.
Exploiting ad hoc meshes in IP based access networks (2003)

Current evolutionary work related to radio access networks is moving towards more flexible deployment architectures with lower deployment costs. However, these architectures are still not geared towards supporting broadband services or providing temporary coverage extensions. This paper has introduced an architecture for supporting ad hoc mesh extensions to IP based access networks for the purposes of increasing bandwidth and providing a simple and cost effective means to extend the coverage. The ad hoc mesh extensions are only feasible for certain business models where the ad hoc mesh infrastructure is owned by a single operator i.e. ad hoc meshes of user nodes are only feasible in closed communities where trust issues are not prohibitive. An architectural framework has been outlined that splits the ad hoc mesh problem space into manageable components that can be solved independently. The solutions to the framework aspects can then be slotted together to provide support for ad hoc mesh extensions. The major outstanding issues that need to be addressed to enable this architecture have also been highlighted.
Sigma Overbounding using a Position Domain Method for the Local Area Augmentaion of GPS (2009)

The local area augmentation system (LAAS) is a differential GPS navigation system being developed to support aircraft precision approach and landing navigation with guaranteed integrity and availability. While the system promises to support Category I operations, significant technical challenges are encountered in supporting Category II and III operations. The primary concern has been the need to guarantee compliance with stringent requirements for navigation availability. This paper describes how a position domain method (PDM) may be used to improve system availability by reducing the inflation factor for standard deviations of pseudo-range correction errors. Used in combination with the current range domain method (RDM), a 30% reduction in the inflation factor is achieved with the same safety standard. LAAS prototype testing verifies the utility of the PDM to enhance Category II/III user availability.