gebhart/patrepeval huggingface dataset:
Functionality and stability of heparin immobilized onto poly (dimethylsiloxane) (2005)

Poly(dimethylsiloxane) (PDMS) has become an attractive material when working in the field of microfluidics, mainly because of the rapid prototyping process it involves. The increased surface volume ratio in microchannels makes the interaction between sample and material surface highly important, evident when handling complex biological samples such as plasma or blood. This study demonstrates a new grade of non-covalent heparin surface that adds efficient anticoagulant property to the PDMS material. The surface modification is a simple and fast one-step process performed at neutral pH, optimal when working with closed microsystems. The heparin formed a uniform and functional coating on hydrophobic PDMS with comparatively high level of antithrombin-binding capacity. In addition, long-term studies revelaed that the immobilized heparin was more or less stable in the microchannels over a time of three weeks. Recalcified plasma in contact with native PDMS showed complete coagulation after 1 h, while no fibrin formation was detected in plasma incubated on heparin-coated PDMS within the same time. In conclusion, we see the heparin coating developed and evaluated in this study as a tool that greatly facilitates the use of PDMS in microfluidics dealing with plasma or blood samples.
Focus-tunable and Fixed Lenses and Stereoscopic 3D Displays (2017)

International audience
Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model (2011)

Implantable cardiovascular devices are manufactured from artificial materials (e.g. titanium (Ti), expanded polytetrafluoroethylene), which pose the risk of thromboemboli formation1,2,3. We have developed a method to line the inside surface of Ti tubes with autologous blood-derived human or porcine endothelial progenitor cells (EPCs)4. By implanting Ti tubes containing a confluent layer of porcine EPCs in the inferior vena cava (IVC) of pigs, we tested the improved biocompatibility of the cell-seeded surface in the prothrombotic environment of a large animal model and compared it to unmodified bare metal surfaces5,6,7 (Figure 1). This method can be used to endothelialize devices within minutes of implantation and test their antithrombotic function in vivo. Peripheral blood was obtained from 50 kg Yorkshire swine and its mononuclear cell fraction cultured to isolate EPCs4,8. Ti tubes (9.4 mm ID) were pre-cut into three 4.5 cm longitudinal sections and reassembled with heat-shrink tubing. A seeding device was built, which allows for slow rotation of the Ti tubes. We performed a laparotomy on the pigs and externalized the intestine and urinary bladder. Sharp and blunt dissection was used to skeletonize the IVC from its bifurcation distal to the right renal artery proximal. The Ti tubes were then filled with fluorescently-labeled autologous EPC suspension and rotated at 10 RPH x 30 min to achieve uniform cell-coating9. After administration of 100 USP/ kg heparin, both ends of the IVC and a lumbar vein were clamped. A 4 cm veinotomy was performed and the device inserted and filled with phosphate-buffered saline. As the veinotomy was closed with a 4-0 Prolene running suture, one clamp was removed to de-air the IVC. At the end of the procedure, the fascia was approximated with 0-PDS (polydioxanone suture), the subcutaneous space closed with 2-0 Vicryl and the skin stapled closed. After 3 - 21 days, pigs were euthanized, the device explanted en-block and fixed. The Ti tubes were disassembled and the inner surfaces imaged with a fluorescent microscope. We found that the bare metal Ti tubes fully occluded whereas the EPC-seeded tubes remained patent. Further, we were able to demonstrate a confluent layer of EPCs on the inside blood-contacting surface. Concluding, our technology can be used to endothelialize Ti tubes within minutes of implantation with autologous EPCs to prevent thrombosis of the device. Our surgical method allows for testing the improved biocompatibility of such modified devices with minimal blood loss and EPC-seeded surface disruption.
Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis (2009)

Electrochemical impedimetric recognition by anti-mycolic acid antibodies, present in tuberculosis (TB)-positive human serum co-infected with human immunodeficiency virus (HIV), of mycolic acids (MA) integrated into a self-assembled monolayer of N-(2-mercaptoethyl)octadecanamide on a gold electrode is described, proving that the MA-based electrode can satisfactorily discriminate between a TB-positive and a TB-negative serum, thus offering promise as a potential impedimetric immunosensing platform for active tuberculosis.
Unusual structural evolution in KCuF3at high temperatures by neutron powder diffraction (2013)

High-resolution neutron powder diffraction has been performed to study the structural evolution of the perovskite KCuF${}_{3}$ at temperatures up to 900 K. Results of the Rietveld refinement reveal an unusual site distortion that increases as temperature increases. In contrast to the widely accepted assumption that a cooperative Jahn-Teller transition may occur at 800 K, no phase transition was observed up to 900 K. We have made a comparative study of the Jahn-Teller distortion in fluorides and oxides with variables such as temperature, pressure, and the dilution by non-Jahn-Teller active ions in these compounds.
N-terminal domain of eotaxin-3 is important for activation of CC chemokine receptor 3 (2002)

Eotaxin-3 belongs to the CC chemokine family, and specifically recognizes CC chemokine receptor (CCR) 3 that is expressed on eosinophils, basophils and helper T type 2 cells. The three-dimensional structure of eotaxin-3 determined by nuclear magnetic resonance has revealed that the N-terminal nine residues preceding the first cysteine comprise an unstructured domain, which is also observed in other chemokine molecules. In order to determine the function of the N-terminal domain of eotaxin-3, we constructed various N-terminal-deletion mutants, and then examined their binding and chemotactic activities toward eosinophils in vitro. Competitive binding studies showed that the binding affinity of truncated mutant toward CCR3 was almost the same as that of wild-type eotaxin-3 even though the N-terminal truncation involved the first through to the ninth residues. In contrast, the chemotactic activity gradually decreased with extension of the N-terminal deletion, and when the deletion extended to the eighth residue, the activity was not detected at all. Thus, the N-terminal nine residues are not critical for binding but the N-terminal eight residues are essential for activation of CCR3. The truncated eotaxin-3 proteins lacking the N-terminal eight or nine residues inhibited the chemotactic activity of chemokines that recognize CCR3. The truncated mutants can possibly be used for anti-allergic and anti-HIV-1 therapy.
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA (2018)

Abstract Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor–immune interfaces through defined T cell/antigen interactions. We treated two patients with metastatic Merkel cell carcinoma with autologous Merkel cell polyomavirus specific CD8+ T cells and immune-checkpoint inhibitors. In both cases, dramatic remissions were associated with dense infiltration of activated CD8+s into the regressing tumors. However, late relapses developed at 22 and 18 months, respectively. Here we report single cell RNA sequencing identified dynamic transcriptional suppression of the specific HLA genes presenting the targeted viral epitope in the resistant tumor as a consequence of intense CD8-mediated immunologic pressure; this is distinguished from genetic HLA-loss by its reversibility with drugs. Transcriptional suppression of Class I loci may underlie resistance to other immunotherapies, including checkpoint inhibitors, and have implications for the design of improved immunotherapy treatments.
Role of cell type and animal species in tumor metastasis (2004)

Photodynamic therapy (PDT) is now a reasonably well-known therapeutic option and is approved as a first line treatment of age-related macular degeneration (AMD), a non-oncologic condition. For most cancer applications PDT is approved mainly as a palliative or adjunctive treatment often when all other options have failed. As the modality evolves toward becoming a first-line or curative option, long-term effects of processes involved will need to be studied. Cellular and tissue responses to PDT are more complex than responses to the more conventional therapies, perhaps because PDT is inherently a binary (or ternary) therapy. In addition to the nature and localization of the photosensitizer (PS), the timing of illumination after administration, the mode of administration and the PS and light doses, the efficacy and selectivity of responses are also determined by the physiology and geometry of tumors, the inherent survivability of tumor cells (in circulation and other anatomic sites) and cellular and molecular responses to PDT. The overall outcome of photodynamic treatment in the long term is determined by a combination, in varying degrees, of all of the above factors. In order to enhance and broaden the application of PDT to complex anatomical sites, an understanding of these factors would be useful. In the laboratory, the outcome is also dependent on the specific animal models being studied. This manuscript discusses preliminary studies along these lines using a variety of tools and implications, if any, of the results obtained.
In Vivo Selection of Hepatocytes Transduced with Adeno-Associated Viral Vectors (2000)

A murine model for hereditary tyrosinemia Type I (HTI) was evaluated for in vivo gene therapy with adeno-associated viral (AAV) vectors expressing the enzyme fumarylacetoacetate hydrolase. Transduction of a limited number of hepatocytes was accomplished following infusion of vector into the portal circulation. Corrected hepatocytes were expanded in vivo by withdrawing a drug which prevents the accumulation of toxic metabolites. The liver was eventually repopulated with hepatocytes harboring a functional and apparently integrated AAV provirus. Recipient animals regained normal liver function and architecture and the underlying metabolic derangements were normalized. After 9 months, vector-treated animals showed benign hepatomas, whereas in untreated animals areas of marked dysplasia were present within hepatomas.
ChemInform Abstract: Synthesis of Succinate Containing Dipeptide Isosteres via Carbonylation of Enol Triflates. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Organic Nitrates: New Concepts for Old Drugs (1996)

Organic nitrates have been in therapeutic use for the treatment of angina pectoris for over a century. Recently it was reported that the release of nitric oxide (NO), mediated by a cascade of biochemical events, is responsible for the pharmacological activity of these compounds. The organic nitrates most commonly used, (glyceryl trinitrate (GTN), isosorbide dinitrate (ISDN), isosorbide-5-mononitrate (IS-5-MN) and nicorandil), are useful for the treatment of stable, unstable and Prinzmetal's angina pectoris, for congestive heart failure and myocardial infarction. Nowadays new applications for these compounds, such as ocular hypotension and the protection of gastric mucosa, are emerging. However, the classical organic nitrates are characterized by undesirable side-effects, such as nitrate tolerance, strong_hypotension, reflex tachycardia and headaches. During the last decade, the search for new organic nitrates with reduced side effects and improved oral bioavailability has greatly intensified. The structural modifications studied in order to solve these problems and the structure-activity relationships for each new class of organic nitrates are reported in this review.
Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas) (2015)

IRB 00006477.
Active phase drift cancellation for optic-fiber frequency transfer using a photonic radio-frequency phase shifter (2014)

We propose an active photonic phase drift cancellation scheme for frequency transfer over optical fiber based on a linear photonic RF phase shifter. The photonic RF phase shifter consists of a dual parallel Mach-Zehnder modulator and optical filter with the assistance of the local microwave signal. The phase drift induced by fiber transmission can be compensated by simply tuning the bias voltage of the modulator. The principle of the phase cancellation scheme based on the photonic phase shifter is demonstrated and validated experimentally by transferring a 0.5 GHz reference signal over a 20 km single-mode fiber with a root mean square jitter of less than 0.5 ps.
Komplexchemie reaktiver organischer Verbindungen, XXV [1] Stabilisierung von Diphenylmethylen und Diphenyldiazomethan in Carbonylcobalt-Komplexen / Complex Chemistry of Reactive Organic Compounds, XXV [1] Stabilization of Diphenylmethylene and Diphenyldiazomethane in Carbonyl Cobalt Complexes (1978)

Low temperature photolysis of (η 5 -C 5 H 5 )Co(CO) 2 with diphenyldiazomethane in tetrahydrofurane yields μ-carbonyl-μ-diphenylmethylene-bis(η 5 cyclopentadienylcobalt) (Co-Co) and μ 3 -earbonyl-μ 3 -(diphenylmethylenehydrazido)(N.N.N)-cyclotris(η 5 -cyclo-pentadienylcobalt) (3 Co-Co). The bridged μ-diphenylmethylene complex is also formed by thermal reaction of (η 5 -C 5 H 5 )Co(CO) 2 with diphenyldiazomethane in boiling benzene.
Comparison of Nickel Nanoparticle-Assisted Diffusion Brazing of Stainless Steel to Conventional Diffusion Brazing and Bonding Processes (2010)

Transient liquid phase diffusion brazing is used in precision, hermetic joining applications as a replacement for diffusion bonding to reduce cycle times, reduce bonding pressure, and improve yields. In the present study, stainless steel 316L laminae are diffusion brazed with an interlayer of nickel nanoparticles and compared with samples joined by conventional diffusion bonding and electroplated nickel-phosphorous diffusion brazing. Comparison is made with regard to microstructural evolution, diffusional profile, and bond strength. All bonding was carried out in a uni-axial vacuum hot press at 1000°C with a heating rate of 10°C/min, a dwell time of 2 h and a bonding pressure of 10 MPa. Bond strength measurements show that the sample brazed with a nickel nanoparticle interlayer has the lowest void fraction at 4.8±0.9% and highest shear strength at 141.3±7.0 MPa. Wavelength dispersive spectroscopic analysis of sample cross-sections shows substantial diffusion of Ni and Fe across the nickel nanoparticle bond line. Scanning electron micrographs show no secondary phases along the nickel nanoparticle bond line.
Session details: SIGGRAPH Core: CGAL - the computational geometry algorithms library (2008)

No abstract available.
Proceedings of the 2nd International Workshop on Hot Topics in Wireless (2015)

It is our great pleasure to welcome you to the Second ACM Workshop on Hot Topics in Wireless (HotWireless 2015). This year's HotWireless continues from where we left off last year. It has an exciting program focused on disruptive wireless technologies and systems that can enable orders of magnitude improvements in performance and novel wireless applications. HotWireless strives to provide a launching pad for bold and visionary ideas, and to bring together experts in hardware, physical layer, networks, and systems to address core technical challenges in these emerging wireless technologies. This year we received 16 submissions, of which we selected 10 for publication. The program committee consisted of 19 wireless experts from around the world, who did a fantastic job to provide an average of 4 reviews per paper. The accepted papers this year include exciting topics, which range from indoor localization and 3-D mapping, to low level wireless communication, to communication with UAVs using free space optics. In addition to the accepted papers, we will also have invited talks from several wireless experts. We look forward to your active participation in this workshop!
Benefits of MIMO Mode Switching, Angular Diversity and Multiuser Multiplexing for LiFi (2021)

We report on the first real-time experiments with distributed MIMO and multiple users for LiFi. MIMO mode switching and angular diversity are beneficial for robustness. Multiuser multiplexing helps in scenarios where users have complementary MIMO channels.
Cost, Capacity, and Performance Analyses for Hybrid SCM/NAND Flash SSD (2014)

Storage class memories (SCMs) are fast and energy-efficient solid-state memories with high endurance. However, the bit cost of SCM is higher than that of NAND flash memory due to its relative production immaturity. As a cost-effective alternative to replace the conventional NAND flash-only solid-state drive (SSD), the hybrid SCM/MLC NAND SSD is a promising next generation storage solution. It is already understood that SCM capacity requirement depends on the workload characteristics. However, the optimum SCM capacity is also determined by the latency parameters of the SCM chips themselves. Therefore, in this paper, the dependencies of SCM capacity on SCM chip latency parameters are analyzed for the hybrid SCM/MLC NAND flash SSD. From the experimental results, increasing SCM capacity to accelerate the SSD performance is feasible when the write and read latencies of the SCM are below 1 μs. Furthermore, SSD energy consumption is more dependent on write rather than read latency. Finally, optimistic and pessimistic models of SCM area cost are considered in order to optimize the cost-efficiency of the SCM chip design in the hybrid SCM/MLC NAND SSD. According to the SCM area cost models, a SCM:NAND capacity ratio of at least 1.5% with a SCM read latency of less than 630 ns is recommended for the Financial1 workload, assuming that the SCM write/read latency ratio is 5.
Imaging cold-induced vasodynamic behaviour in skin using OCT for microangiography (Conference Presentation) (2017)

In dermatology the reflexes of vasoconstriction and vasodilation are known as important mechanisms of thermoregulation of the inner body. Imaging the physiology of microvasculature of the skin with high spatial resolution in three dimensions while reacting to changes in temperature is crucial for understanding the complex processes of vasodynamics, which result in constriction and dilation of vessels. However, previous studies using Laser-Doppler flowmetry and -imaging could not provide reliable angiographic images which allow to quantify changes in blood vessel diameter. Here, we report a different approach for angiographic imaging of microvasculature of a anaesthetized rodent model using speckle variance optical coherence tomography (svOCT) during and after localized cooling. Therefore a commercial OCT with a center wavelength of 1.3 μm and a spatial resolution of 13µm was used in combination with a custom built cooling device to image such reflexes at the mouse ear pinna and dorsal skinfold. Cooling was applied in steps of 2−5◦ C starting at the baseline temperature of 27◦ C down to −10◦ C. To our surprise and in contrast to the general opinion in literature, we were able to observe that the majority of vessels with a diameter larger than 20 μm maintain perfused with a constant diameter when the tissue is cooled from baseline to subzero temperatures. However, vasoconstriction was observed very rarely and only in veins, which led to their occlusion. The results of this experiment lead us to reconsider essential aspects of previous understanding of temperature-induced vasodynamics in cutaneous microvasculature.
Setting Properties of Four Acrylic and Two Calcium-Phosphate Cements Used in Vertebroplasty (2006)

The exothermic reaction of calcium-phosphate cements appears to be insignificant. Although the acrylic cements release considerably greater heat in a much shorter time period, it does not appear that their temperature is sufficiently high to cause extensive thermal injury. However, variations within each group must be considered along with the intended use when deciding on the cement to be used.
Strategies for two-player differential games with costly information (2016)

In this work, a two players nonzero-sum differential game is considered, where one player tries to minimize some predefined cost and the other tries to maximize the same. The game is described by a stochastic differential system and the actions of the players serve as the control inputs to the dynamical system. The cost being a function of the actions chosen by the players and the state of the dynamical system, the players aim to control the state in order to optimize the cost functional. However in this problem the players do not have the access to the states for every time, rather the states are available at discrete time instances after some finite costs are paid by the players. The inclusion of the information-cost makes the structure of the cost functional non-classical. The work presents the strategies for the players under no-cost information access as well as under costly information access. Explicit time instances for the information access are also derived by solving certain finite dimensional optimization problems.
Multi-label Categorization of Accounts of Sexism using a Neural Framework (2019)

Sexism, an injustice that subjects women and girls to enormous suffering, manifests in blatant as well as subtle ways. In the wake of growing documentation of experiences of sexism on the web, the automatic categorization of accounts of sexism has the potential to assist social scientists and policy makers in studying and countering sexism better. The existing work on sexism classification, which is different from sexism detection, has certain limitations in terms of the categories of sexism used and/or whether they can co-occur. To the best of our knowledge, this is the first work on the multi-label classification of sexism of any kind(s), and we contribute the largest dataset for sexism categorization. We develop a neural solution for this multi-label classification that can combine sentence representations obtained using models such as BERT with distributional and linguistic word embeddings using a flexible, hierarchical architecture involving recurrent components and optional convolutional ones. Further, we leverage unlabeled accounts of sexism to infuse domain-specific elements into our framework. The best proposed method outperforms several deep learning as well as traditional machine learning baselines by an appreciable margin.
Large Enhancement of Two-Photon Absorption in Semiconductors Using Highly Non-Degenerate Photons (2010)

We performed frequency non-degenerate pump-probe experiments in several direct-gap semiconductors using femtosecond and picosecond pulses. Tuning the long wavelength photons in the IR region, we observed a 125-fold enhancement of the two-photon absorption coefficient.