gebhart/patrepeval huggingface dataset:
6.7 ${\hbox{Gb/in}}^{2}$ Recording Areal Density on Barium Ferrite Tape (2007)

We investigated the performance of a barium ferrite tape medium in linear tape recording, using a giant-magnetoresistive read head of 0.5 mum track width. A linear density of 400 kbpi with an error rate of 6 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> was demonstrated based on measured recording data and a simulated channel with advanced noise predictive maximum likelihood detection schemes. Using a timing-based servo format that reduces the position error signal (PES) due to medium jitter and servo-writer velocity variations, we achieved a PES of 0.07 mum standard deviation and a maximum PES (in a 10-s interval) of 0.35 mum. This PES magnitude allows the writing and reading of 1.5-mum tracks at 400 kbpi, for an equivalent areal density of 6.7 Gb/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
A Minority of Patients with Type 1 Diabetes Routinely Downloads and Retrospectively Reviews Device Data (2015)

A minority of T1D patients routinely downloads and reviews data from their devices on their own. Further research is needed to understand obstacles, provide better education and tools for self-review, and determine if patient self-review is associated with improved glycemic control.
Specificity Analysis of Murine Monoclonal Antibodies Reactive with Tn, Sialylated Tn, T, and Monosialylated (2 → 6) T Antigens (1996)

T, Tn, and sialyated Tn (sTn) are pancarcinoma antigens, and increased expression of these carbohydrate epitopes has been correlated with a poor prognosis in several epithelial malignancies. Ten murine monoclonal antibodies have been generated to these antigens, and compared by ELISA and immunohistochemistry to established mAbs reactive with these antigens. Nine mAbs (3 IgM and 6 IgG) reactive with synthetic T-human serum albumin (T-HSA) were produced after immunizing BALB/c mice with a synthetic T-keyhole limpet hemocyanin glycoconjugate (T-KLH). An additional IgM mAb (145.22) was produced in mice immunized with erythrocytes isolated from a patient with Tn syndrome. Three IgM and six IgG1 mAbs reactive with T-HSA did not react with natural T antigen present on desialyated glycophorin. All three IgM and several IgG1 mAbs, however, did react with LS-174T, a mucinous colon carcinoma cell line, 647V, a human bladder carcinoma cell line, and TA3Ha, a murine mammary carcinoma cell line as well as fresh frozen colon carcinomas. MAb 145.22 reacted with both natural and synthetic sources of sTn and Tn, as well as with LS-174T cells and mucin deposits in 10/11 colon carcinomas on fresh-frozen sections. MAb B72.3 reacted strongly with ovine submaxillary mucin (OSM) and sTn-HSA, while mAb CC49, a second-generation mAb to TAG-72 carcinoma mucin, reacted strongly with OSM, less strongly with desialyated OSM, and only weakly with sTn-HSA, suggesting that the epitope specificity for mAb CC49 is distinct from that of B72.3.
Guyton’s venous return curves should be taught at medical schools (complete English translation of Japanese version) (2017)

Guyton's most significant contributions are the exploration into the development of venous return and circulatory equilibrium. Recently, several physiologists challenged the validity of venous return as a function of venous pressure. Guyton's experiment in effect controlled venous pressure by changing cardiac output. Thus, critics claimed that cardiac output is the determinant of venous return. This claim is true, but in the presence of constant stressed volume, venous return and venous pressure have a fixed reciprocal relationship. Thus, it is meaningless to argue which one is the independent variable. We fully support Guyton's venous return and in particular circulatory equilibrium. Guyton's framework should be taught at medical schools worldwide.
High-efficiency high-brightness diode lasers at 1470 nm/1550 nm for medical and defense applications (2012)

Diode lasers in the 1400 nm to 1600 nm regime are used in a variety of applications including pumping Er:YAG lasers, range finding, materials processing, aesthetic medical treatments and surgery. In addition to the compact size, efficiency, and low cost advantages of traditional diode lasers, high power semiconductor lasers in the eye-safe regime are becoming widely used in an effort to minimize the unintended impact of potentially hazardous scattered optical radiation from the laser source, the optical delivery system, or the target itself. In this article we describe the performance of high efficiency high brightness InP laser bars at 1470nm and 1550nm developed at QPC Lasers for applications ranging from surgery to rangefinding.
Microelectromechanical tunable capacitors for reconfigurable RF architectures (2006)

This paper reports on metal-based MEMS tunable capacitors, fabricated in a thin-film process on high-ohmic silicon. Continuous and reversible tuning has been demonstrated with an average tuning ratio of 4.5. A quality factor between 100 and 300 has been obtained in a frequency range of 0.5 to 4 GHz. The combination of a high quality factor and large tuning range makes these tunable capacitors very suitable as building blocks in many radio-frequency (RF) applications. The tuning speed, temperature stability and RF power handling have been studied in terms of self-actuation. Finally, the need for a hermetic package as well as a packaging concept which can potentially provide this has been demonstrated. After packaging, the devices can be handled as standard silicon dies, making them fit very well with a system-in-package approach.
Distal triceps tendinopathies (2020)

Abstract Tendinopathy of the distal triceps represents a rare pathology in the upper extremity. Although there is scant scientific evidence published to date, the association with risk factors such as internal diseases or steroid use is commonly described in various reports. Due to traumatic incidents or sporting overuse, partial or complete ruptures can occur. Clinically, stress-related posterior elbow pain, swelling, ecchymosis, loss of strength in extension, and a palpable gap in the tendon can be seen. Physical examination shows reduced extension force and increasing pain with forced extension against resistance. Tendinopathies and resulting partial or complete ruptures can be detected by ultrasound and magnetic resonance imaging. Conservative therapy with temporary immobilization is recommended for tendinopathies or minor ruptures of the triceps tendon. Complete ruptures or larger partial ruptures should be treated surgically with anatomical refixation of the tendon.
A helium-mercury direct nuclear pumped laser (1977)

A 6150-Å He-Hg laser, pumped solely by the 1n (10B,α) 7Li nuclear reaction, has been achieved using the Sandia SPRII reactor. The optimum conditions for lasing were 600 Torr total pressure with 2.5 mTorr Hg partial pressure, with a threshold for lasing of ∼1016 n/cm2 sec. This is the first visible-wavelength laser having nuclear energy as its only source of excitation.
Abstract 3619: Nanoparticle formulation of VERU 111 for pancreatic cancer treatment (2019)

Abstract Background: Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus, developing novel therapeutic strategies will help for the management of this disease. We recently identified VERU-111, a novel synthetic molecule which showed potent anti-cancer effect against PanCa via targeting clinically important βIII and βIV tubulin isoforms. In this study, we synthesized and characterized its novel nanoformulation (MNP-VERU) and evaluated its therapeutic effects in vitro and xenograft mouse model. Methods: MNPs were prepared by chemical precipitation method and loaded with VERU-111 using diffusion method. This formulation was characterized for particle size, chemical composition, and drug loading efficiency, using various physico-chemical methods (TEM, FT-IR, DSC, TGA, and HPLC). The internalization of MNP-VERU was achieved after 6 hours incubation with MNP-VERU in PanCa cells. To determine therapeutic efficacy of MNP-VERU, we performed various in vitro (MTS, wound healing, boyden chamber real-time xCELLigence, and apoptosis assays) and in vivo (mouse tumor xenograft) studies using PanCa. Effect of MNP-VERU on various key oncogenic signaling pathways, and miRNAs was evaluated by Western blot, immunohistochemistry (IHC), confocal microscopy, qRT-PCR and in situ hybridization (ISH) analyses respectively. Result: Our novel MNP-VERU formulation provided average size of 110 nm in dynamic light scattering (DLS) and exhibited -8.23 to -11.65 mV zeta potential with an outstanding loading efficiency (94%). Cellular uptake and internalization studies demonstrate that MNP-VERU escape lysosomal degradation, providing efficient endosomal release to cytosol. MNP-VERU showed remarkable anti-cancer potential in various PanCa cells (Panc-1, AsPC-1, HPAF-II, BxPC-3, MiaPaca) and more effectively repressed βIII and βIV tubulin isoforms via restoring the expression of miR-200c. MNP-VERU more effectively suppressed AsPC-1 cells derived xenograft tumors in athymic nude mice. Conclusions: Taken together, our results suggest that MNP-VERU has more anti-cancer potential than free VERU-111 against PanCa. MNP-VERU may reduce the toxicity and improve the bioavailability of free VERU-111 and could be used for the management of PanCa. Citation Format: Vivek K. Kashyap, Bilal B. Hafeez, Qinghui Wang, Neeraj Chauhan, Prashanth K. Nagesh, Murali M. Yallapu, Duane D. Miller, Wei Li, Meena Jaggi, Subhash C. Chauhan. Nanoparticle formulation of VERU 111 for pancreatic cancer treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3619.
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma. (2002)

The GSTP1 gene encodes for an enzyme, glutathione S-transferase pi (GSTpi),involved in detoxification of carcinogens. An aminoacid substitution (I105V) in GSTP1 produces a variant enzyme with lower activity and less capability of effective detoxification. This variant GSTP*B allele has been associated with a propensity to develop several neoplasms. Because GSTP1 promoter hypermethylation and inactivation of GSTpi expression is a frequent alteration in prostate carcinoma, we hypothesized that this somatic epigenetic modification could obviate any reduced enzyme activity caused by the germ-line polymorphism. We tested for the GSTP1 genotype in a population of prostate cancer patients, and in a control group composed of patients with benign prostatic hyperplasia (BPH) and healthy blood donors. Tissue samples from the 105 prostate cancer cases (105 adenocarcinomas and 34 prostatic intraepithelial neoplasia lesions), and from 43 BPH patients were tested for GSTP1 hypermethylation by methylation-specific PCR. GSTpi protein expression was assessed by immunohistochemistry. No significant effect on prostate cancer risk was detectable for GSTP1 genotype compared with the control population (odds ratio, 1.02; 95% confidence interval, 0.59-1.75). Moreover, no association was found between this genotype and tumor or BPH methylation status. Patients with unmethylated carcinomas did not disclose significant differences in genotypic distribution compared with the control population. In adenocarcinoma, a strong association (P < 0.00001) between GSTP1 promoter hypermethylation and loss of GSTpi expression was observed; however, this trend was not retained in prostatic intraepithelial neoplasia or BPH lesions. Although the GSTP1 polymorphism is not associated with altered susceptibility to prostate cancer, somatic promoter hypermethylation is an effective, but not the only, cause of decreased GSTpi function.
The Road We Must Take: Multidisciplinary Team Science (2010)

Translational research is acknowledged to be complex and to require a diverse skill set. Many organizations, particularly academic institutions, have invested in educational programs, facilities, and enhanced resources to encourage translational research. Critically needed, however, is an emphasis on creating and sustaining multidisciplinary research teams. It is through the power of many and a diverse approach to our health care problems that we will realize lasting solutions.
pO2-weighted imaging in vivo by delayed fluorescence of intracellular protoporphyrin IX: publisher’s note (2020)

This publisher's note contains corrections to Opt. Lett.45, 284 (2020)OPLEDP0146-959210.1364/OL.45.000284.
Handwritten sentence recognition (2002)

We present a system for reading handwritten sentences and paragraphs. The system's main components are preprocessing, feature extraction and recognition. In contrast to other systems, whole lines of text are the basic units for the recognizer. Thus the difficult problem of segmenting a line of text into individual words can be avoided. Another novel feature of the system is the incorporation of a statistical language model into the recognizer. Experiments on the database described previously by the authors (1999) have shown that a recognition rate on the word level of 79.5% and 60.05% for small (776 words) and larger (7719 words) vocabularies can be reached. These figures increase to 84.3% and 67.32% if the top ten choices are taken into account.
Proposal of Brillouin optical correlation-domain reflectometry (BOCDR) (2008)

We propose a Brillouin optical correlation-domain reflectometry (BOCDR), which can measure the distribution of strain and/or temperature along an optical fiber from a single end, by detecting spontaneous Brillouin scattering with controlling the interference of continuous lightwaves. In a pulse-based conventional Brillouin optical time-domain reflectometry (BOTDR), it is difficult in principle to achieve a spatial resolution less than 1 m, and the measurement time is as long as 5-10 minutes. On the contrary, the continuous-wave-based BOCDR can exceed the limit of 1-m resolution, and realize much faster measurement and random access to measuring positions. Spatial resolution of 40 cm was experimentally demonstrated with sampling rate of 50 Hz.
First-order nonadiabatic couplings from time-dependent hybrid density functional response theory: Consistent formalism, implementation, and performance (2010)

First-order nonadiabatic coupling matrix elements (NACMEs) are key for phenomena such as nonradiative transitions and excited-state decay, yet a consistent and practical first principles treatment has been elusive for molecules with more than a few heavy atoms. Here we present theory, implementation using Gaussian basis sets, and benchmarks of first-order NACMEs between ground and excited states in the framework of time-dependent hybrid density functional theory (TDDFT). A time-dependent response approach to NACMEs which avoids explicit computation of excited-state wave functions is outlined. In contrast to previous approaches, the present treatment produces exact analytical derivative couplings between time-dependent Kohn-Sham (TDKS) determinants in a finite atom-centered basis set. As in analytical gradient theory, derivative molecular orbital coefficients can be eliminated, making the computational cost independent of the number of nuclear degrees of freedom. Our expression reduces to the exact Chernyak-Mukamel formula for first-order NACMEs in the complete basis-set limit, but greatly improves basis-set convergence in finite atom-centered basis sets due to additional Pulay type terms. The Chernyak-Mukamel formula is shown to be equivalent to the Hellmann-Feynman contribution in analytical gradient theory. Our formalism may be implemented in TDDFT analytical excited-state gradient codes with minor modifications. Tests for systems with up to 147 atoms show that evaluation of first-order NACMEs causes total computation times to increase by an insignificant 10% on average. The resolution-of-the-identity approximation for the Coulomb energy (RI-J) reduces the computational cost by an order of magnitude for nonhybrid functionals, while errors are insignificant with standard auxiliary basis sets. We compare the computed NACMEs to full configuration interaction (FCI) in benchmark results for diatomic molecules; hybrid TDDFT and FCI are found to be in agreement for regions of the potential energy curve where the Kohn-Sham ground-state reference is stable and the character of the excitation is properly captured by the present functionals. With these developments, nonadiabatic molecular dynamics simulations of molecular systems in the 100 atoms regime are within reach.
Jet fragmentation transverse momentum measurements from di-hadron correlations in $$ \sqrt{\mathrm{s}}=7 $$ TeV pp and $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ TeV p–Pb collisions (2019)

A bstract The transverse structure of jets was studied via jet fragmentation transverse momentum ( j T ) distributions, obtained using two-particle correlations in proton-proton and proton-lead collisions, measured with the ALICE experiment at the LHC. The highest transverse momentum particle in each event is used as the trigger particle and the region 3 &lt; p Tt &lt; 15GeV/ c is explored in this study. The measured distributions show a clear narrow Gaussian component and a wide non-Gaussian one. Based on Pythia simulations, the narrow component can be related to non-perturbative hadronization and the wide component to quantum chromodynamical splitting. The width of the narrow component shows a weak dependence on the transverse momentum of the trigger particle, in agreement with the expectation of universality of the hadronization process. On the other hand, the width of the wide component shows a rising trend suggesting increased branching for higher transverse momentum. The results obtained in pp collisions at $$ \sqrt{s}=7 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>7</mml:mn></mml:math> TeV and in p–Pb collisions at $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:msub><mml:mi>s</mml:mi><mml:mrow><mml:mi>N</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:msqrt><mml:mo>=</mml:mo><mml:mn>5.02</mml:mn></mml:math> TeV are compatible within uncertainties and hence no significant cold nuclear matter effects are observed. The results are compared to previous measurements from CCOR and PHENIX as well as to P ythia 8 and Herwig 7 simulations.
Symmetric Constrained Optimal Control (2015)

This paper extends previous results on symmetry in strictly convex linear model predictive control to non-strictly convex and nonlinear model predictive control. We define symmetry for constrained systems, controllers, and model predictive control problems. We show that symmetric model predictive control problems produce symmetric controllers. We show that the previously established methods of memory reduction can be applied to non-strictly convex problems. We apply these memory reduction techniques to the battery balancing problem. Exploiting symmetry leads to an exponential memory reduction and simple, intuitive optimal controllers.
Accurate genetic testing platform based on haploid templates: Use in inheritable colon cancer. (2005)

Extract: The misfortune of individuals having inherited a genetic mutation that predisposes them to cancer can become a weapon for their better management of the disease and the rest of their family members. This is what the promise of genetic testing is: to reduce the mortality and morbidity through screening, and hopefully lead to early diagnosis and even prevention of spread or the cancer itself. Inherited forms of cancer represent a good example of the benefits and complications of genetic testing. A single inherited mutant gene usually is enough to confer a high risk of cancer. The mutation is inherited from one of the parents and it is transmitted to the offspring. Other siblings may also have inherited the mutant gene. This way, some members of the family will have that one mutation and some will not. Therefore, when an inherited mutation is identified in one member of a family, the rest of the family members can be screened for the presence of this mutation. So, the mutation can be identified early, before any clinical symptoms, and this allows the potential disorder to be managed appropriately.
Terpenoid-derived conjugated dienes with exo-methylene and a 6-membered ring: high cationic reactivity, regioselective living cationic polymerization, and random and block copolymerization with vinyl ethers (2021)

Biobased <italic>exo</italic>-methylene-conjugated dienes underwent regioselective living cationic polymerization to result in well-defined homo- and copolymers with good thermal properties.
Learning Motion Priors for 4D Human Body Capture in 3D Scenes (2021)

Recovering high-quality 3D human motion in complex scenes from monocular videos is important for many applications, ranging from AR/VR to robotics. However, capturing realistic human-scene interactions, while dealing with occlusions and partial views, is challenging; current approaches are still far from achieving compelling results. We address this problem by proposing LEMO: LEarning human MOtion priors for 4D human body capture. By leveraging the large-scale motion capture dataset AMASS [38], we introduce a novel motion smoothness prior, which strongly reduces the jitters exhibited by poses recovered over a sequence. Furthermore, to handle contacts and occlusions occurring frequently in body-scene interactions, we design a contact friction term and a contact-aware motion infiller obtained via per-instance self-supervised training. To prove the effectiveness of the proposed motion priors, we combine them into a novel pipeline for 4D human body capture in 3D scenes. With our pipeline, we demonstrate high-quality 4D human body capture, reconstructing smooth motions and physically plausible body-scene interactions. The code and data are available at https://sanweiliti.github.io/LEMO/LEMO.html.
Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs (2022)

Abstract Plasmodium genomes encode multiple RAP (RNA-binding domain abundant in Apicomplexan) domain proteins that contain a conserved module of 56 to 73 amino acids. Here, we characterized two of the P. falciparum RAP domain proteins; PfRAP291 &amp; PfRAP070, for their expression and role at asexual blood stages. RNA binding assays and high-throughput CLIP-seq analysis showed that these proteins mainly bind ribosome associated RNAs. Blue-native PAGE and protein-protein interaction studies suggested association of these proteins with MSP-1 complex. Anti-PfRAP291 and anti-PfRAP070 antibodies showed moderate inhibitions in in-vitro merozoite invasion assays. Together, these results suggest multiple roles of these proteins; PfRAP291 and PfRAP070, in merozoite invasion and in ribosome regulation during asexual stages of the parasite.