gebhart/patrepeval huggingface dataset:
Investigating the Effect of Service Quality on Customer Post-Purchasing Behaviors in the Hotel Sector: The Moderating Role of Service Convenience (2012)

This study contributes to a conceptual model indicating the effect of service quality on customer post-purchasing behaviors in the hotel sector by including both the mediating role of customer satisfaction and the moderating role of customer-perceived service convenience. The analysis confirms that customer satisfaction is positively influenced by service quality whereas behavioral intention is positively influenced by customer satisfaction. Therefore, behavioral intention is indirectly influenced by service quality through customer satisfaction. Finally, another key finding is that the relationship between customer satisfaction and behavioral intention is stronger for customers who perceive high service convenience than for those who perceive low service convenience. According to these findings, implications and future research directions are discussed.
Approximately Lower Triangular Ensembles of LDPC Codes With Linear Encoding Complexity (2007)

The complexity of brute-force encoding of low-density parity-check (LDPC) codes is proportional to the square value of the block length. Richardson and Urbanke have proposed efficient encoding algorithms for LDPC codes. These algorithms permute the parity-check matrix of the code iteratively, such that it becomes approximately lower triangular. We propose a new approach for efficient encoding of LDPC codes in which we modify the code ensemble to force an approximate lower triangular structure, thus eliminating the need to apply the algorithms of Richardson and Urbanke in this ensemble. We prove that the new ensemble has the same asymptotic threshold as the corresponding standard ensemble. The new ensemble can be used for linear time encoding of an arbitrary code profile. Computer simulations confirm that the performances of the standard and new ensembles are also very similar when using finite length codes
Systemic Delivery of Stable siRNA-Encapsulating Lipid Vesicles: Optimization, Biodistribution, and Tumor Suppression (2014)

Lipid-based nanoparticles are considered as promising candidates for delivering siRNA into the cytoplasm of targeted cells. However, in vivo efficiency of these nanoparticles is critically dependent on formulation strategies of lipid-siRNA complexes. Adsorption of serum proteins to lipid-siRNA complexes and its charge determine siRNA degradation and serum half-life, thus significantly altering the bioavailability of siRNA. To address these challenges, we developed a formulation comprising dihydroxy cationic lipid, N,N-di-n-hexadecyl-N,N-dihydroxyethylammonium chloride (DHDEAC), cholesterol, and varying concentrations of 1,2-distearoryl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol-2000)] (DSPE-PEG 2000). Using an ethanol dilution method, addition of these lipids to siRNA solution leads to formation of stable and homogeneous population of siRNA-encapsulated vesicles (SEVs). Biodistribution of these SEVs, containing 5 mol % of DSPE-PEG 2000 in xenograft mice, as monitored by live animal imaging and fluorescence microscopy, revealed selective accumulation in the tumor. Remarkably, four intravenous injections of the modified vesicles with equimolar amounts of siRNA targeting ErbB2 and AURKB genes led to significant gene silencing and concomitant tumor suppression in the SK-OV-3 xenograft mouse model. Safety parameters as evaluated by various markers of hepatocellular injury indicated the nontoxic nature of this formulation. These results highlight improved pharmacokinetics and effective in vivo delivery of siRNA by DHDEAC-based vesicles.
Effect of molecular therapeutics on liver regeneration in a murine model (2007)

Van Buren, George MD; Yang, Anthony D. MD; Dallas, Nikolaos A. MD; Gray, Michael J. PhD; Lim, Sherry J. MD; Xia, Ling BS; Fan, Fan BS; Wu, Yan PhD; Hicklin, Daniel J. PhD; Ellis, Lee M. MD Author Information
A 586 MHz microcontroller compensated MEMS oscillator based on ovenized aluminum nitride contour-mode resonators (2012)

This work reports on the demonstration of a Microcontroller Compensated MEMS Oscillator based on a UHF ovenized AlN CMR, which shows temperature stability, short-term stability, and acceleration sensitivity comparable to SAW-based oscillators. Over the temperature range -25 ÷ 85°C, the demonstrated 586 MHz oscillator exhibits a temperature stability of 1.7 ppm, stable phase noise values better than -91 dBc/Hz at 1 kHz, and -160 dBc/Hz at 40 MHz offsets, and acceleration sensitivity values better than 30 ppb/g. The design of the integrated heater all-around the top RF electrodes and the new digital temperature controller allowed to simplify the fabrication process compared to our previous demonstration, and to virtually compensate frequency shifts of any origin, i.e. from both the MEMS and the electronic circuitry.
Regenerative medicine in orthopaedic surgery (2007)

Regenerative medicine holds great promise for orthopaedic surgery. As surgeons continue to face challenges regarding the healing of diseased or injured musculoskeletal tissues, regenerative medicine aims to develop novel therapies that will replace, repair, or promote tissue regeneration. This review article will provide an overview of the different research areas involved in regenerative medicine, such as stem cells, bioinductive factors, and scaffolds. The potential use of stem cells for orthopaedic tissue engineering will be addressed by presenting the current progress with skeletal muscle-derived stem cells. As well, the development of a revascularized massive allograft will be described and will serve as a prototypic model of orthopaedic tissue engineering. Lastly, we will describe current approaches used to design cell instructive materials and how they can be used to promote and regulate the formation of bony tissue.
Practical Experience Gained Operating a Compact Ultradeepwater Drill Ship (2013)

Abstract This paper describes the practical experiences gained during the first year of operation of a new Panamax-size ultra deepwater drill ship. The vessel started operations in the Gulf of Mexico in July 2012. The practical experience is offset against the vessel's design expectations: improved safety, an increased drilling efficiency and reduced operational costs. The drill ship is of an integrated design covering vessel, drill tower and equipment handling. The drill ship offers an equal payload compared to other ultra deepwater drill ships but at half the displacement. This paper details the effects of the highly automated onboard material and equipment handling on the vessel's drilling efficiency and on the operational cost. The material and equipment handling is designed around the box girder drill tower that has no V-door limitation and features a drilling side and a construction side, thus minimising flat time. Stands built on one side of the tower can be stored in two set back drums, one on each side of the tower, and taken out when needed. Four pipe handlers are available for handling purposes. This paper covers the field experience with all features of the drill tower that are designed to save time and/or increase efficiency and/or enhance onboard safety. These include the drill tower's dual drawworks eliminating slip-cut procedures, the passive and active heave compensation on the drawworks, and the splittable blocks. The latter allow increasing the block speed for lighter loads. Introduction The tendency in rig building has been an evolutionary trajectory to larger and larger units - currently up to approximately 100,000mt displacement - to enable operations at remote locations, in extreme water depths and under difficult drilling conditions. The building costs and thus the day rates of these units are high. Given their size, the fuel consumption and associated costs and emissions can be significant compared to smaller units. Furthermore, their large sizes limit their field of operation as they are not able to pass certain canals or bridges. In 2007 Huisman started to design a revolutionary unit. The design objectives were to create a compact drill ship capable of drilling complex wells in ultradeepwater. Huisman utilized its integrated design approach: a team of engineers with various disciplines such as Mechanical Engineering, Naval Architecture, Electrical Engineering etc. worked simultaneously together with clients, Noble Drilling and Royal Dutch Shell, who delivered valuable operational input. After approximately 10 months of engineering and various discussion sessions with the clients, Huisman presented the HuisDrill 12000 design.
Wireless Scheduling with Partial Channel State Information: Large\n Deviations and Optimality (2014)

We consider a server serving a time-slotted queued system of multiple\npacket-based flows, with exogenous packet arrivals and time-varying service\nrates. At each time, the server can observe instantaneous service rates for\nonly a subset of flows (from within a fixed collection of observable subsets)\nbefore scheduling a flow in the subset for service. We are interested in\nqueue-length aware scheduling to keep the queues short, and develop scheduling\nalgorithms that use only partial service rate information from subsets of\nchannels to minimize the likelihood of queue overflow in the system.\nSpecifically, we present a new joint subset-sampling and scheduling algorithm\ncalled Max-Exp that uses only the current queue lengths to pick a subset of\nflows, and subsequently schedules a flow using the Exponential rule. When the\ncollection of observable subsets is disjoint, we show that Max-Exp achieves the\nbest exponential decay rate, among all scheduling algorithms using partial\ninformation, of the tail of the longest queue in the system. Towards this, we\nemploy novel analytical techniques for studying the performance of scheduling\nalgorithms using partial state, which may be of independent interest. These\ninclude new sample-path large deviations results for processes obtained by\nnon-random, predictable sampling of sequences of independent and identically\ndistributed random variables. A consequence of these results is that scheduling\nwith partial state information yields a rate function significantly different\nfrom scheduling with full channel information. In the special case when the\nobservable subsets are singleton flows, i.e., when there is effectively no a\npriori channel-state information, Max-Exp reduces to simply serving the flow\nwith the longest queue; thus, our results show that to always serve the longest\nqueue in the absence of any channel-state information is large-deviations\noptimal.\n
Auditing Differentially Private Machine Learning: How Private is Private SGD? (2020)

We investigate whether Differentially Private SGD offers better privacy in practice than what is guaranteed by its state-of-the-art analysis. We do so via novel data poisoning attacks, which we show correspond to realistic privacy attacks. While previous work (Ma et al., arXiv 2019) proposed this connection between differential privacy and data poisoning as a defense against data poisoning, our use as a tool for understanding the privacy of a specific mechanism is new. More generally, our work takes a quantitative, empirical approach to understanding the privacy afforded by specific implementations of differentially private algorithms that we believe has the potential to complement and influence analytical work on differential privacy.
Evaluation of novel fluorinated resist matrices for 157-nm lithography (2003)

As part of a new generation of more transparent 157 nm resist platforms we are developing, a novel resist system is described that has higher transparency and contrast than AZ FX 1000P. Using a new protecting group strategy, encouraging results have been obtained with both poly(&alpha;,&alpha;-bis(trifluoromethyl)bicyclo(2.2.1)hept-5-ene-2-ethanol) and a more transparent perfluorinated resin (TFR). These new resist systems show absorbance values as low as 1 &mu;m<sup>-1</sup> at 157 nm, have twice the contrast (<i>i.e</i>., 12 instead of 7) of AZ FX 1000P, and have neither significant dark erosion nor do they switch to negative tone behavior within the dose range studied. The dry etch resistance of the TPR platform is found to be superior to APEX-E DUV resist for polysilicon but somewhat lower for oxide etches. Features as small as 50 nm lines and spaces were resolved for slightly relaxed pitches (1:1.5 micron). By adjusting the base level it is possible to improve the photospeed by a factor of more than 10 while still maintaining a resolution of 70 nm L/S features.
Optical signal processing for wireless transmission (2011)

Millimeter-wave bands are attracting attention because of the availability of wideband for high-speed transmission. However, due to the limitation of the performance of electric signal processing, it is rather difficult to modulate and demodulate millimeter-wave signals with high-speed baseband modulation. In this paper, we describe optical signal processing for high-speed modulation of millimeter-wave, based on high-speed and precise lightwave control. In optical fiber communication systems, various types of modulation formats, such as quadrature-amplitude-modulation, are reported to achieve high-speed transmission. Optical two-tone signals can be converted into millimeter-wave signals by using high-speed photodetectors. This technique can be used for distribution of stable reference signals in large-scale antenna arrays for radio astronomy. By using the millimeter-wave signal generation technique and the optical advanced modulation formats, we can achieve high-speed modulation of millimeter-waves, where the carrier frequency and bit rate can be over 90GHz and 40Gb/s, respectively.
BARIS: A phase I trial to evaluate the safety and tolerability of combined BIBF 1120 and RAD001 in solid tumors and to determine the maximum tolerated dose (MTD) of the combination. (2014)

TPS2645^ Background: Simultaneous inhibition of several signalling pathways involved in angiogenesis as well as in tumor cell growth regulation by kinase inhibitor combination therapy may increase therapeutic efficacy. Here we evaluate the combination of the mTOR-inhibitor RAD001 (everolimus) and the triple kinase (FGFR, VEGFR, PDGFR) inhibitor BIBF 1120 in a phase I trial in advanced solid tumors. In addition we use DCE-MRI for early identification of patients with benefit from BIBF 1120 Methods: Patients in arm A receive 5 mg of RAD001 and 2 x 150 mg BIBF 1120, in arm B 10 mg RAD001 and 2 x 150 mg BIBF 1120 will be administered, whereas in arm C, 10 mg of RAD001 and 2 x 200 mg BIBF 1120 will be given. Eligible are all patients with relapsed or refractory advanced/metastatic solid tumors and an ECOG performance state of 0-1 for whom no further standard therapies are available. All patients will start with a 2-week run-in phase of 2 x 200 mg BIBF 1120. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans will be performed at baseline staging, on day 3 and day 14. On day 14, there will also be 12 hours-pharmacokinetic (PK) assessment. Combination therapy starts on day 15. On day 29, a DCE-MRI scan and 12-hours PK will be performed. Restaging is performed on day 57. Patients who experience clinical benefit (i. e., response or stable disease) on day 57 with adequate tolerability of the combination will further receive the medication, as long as the benefit lasts. Results: 15 patients have been enrolled so far in arm A and B, and one patient started in arm C. Of the enrolled patients, the majority (9 patients) had non-small cell lung cancer (NSCLC) as the underlying tumor. Two patients turned out to be screening failures in arm B. The trial procedures proved to be feasible. Discussion: So far, the combination of BIBF 1120 and RAD001 has reached its predefined third dosage step. We expect the termination of the trial by summer 2014. In case of efficacy in a molecular defined subset of patients, an expansion phase (phase II) is planned. Clinical trial information: NCT01349296.
Online story scheduling in web advertising (2009)

We study an online job scheduling problem motivated by storyboarding in web advertising, where an advertiser derives value from uninterrupted sequential access to a user surfing the web. The user ceases to browse with probability 1 -- β at each step, independently. Stories (jobs) arrive online; job s has length ls and per-unit value vs. A value vs is obtained for every unit of the job that is scheduled consecutively without interruption, discounted for the time at which it is scheduled. Jobs can be preempted, but no further value can be derived from the residual unscheduled units of the job. We seek an online algorithm whose total reward is competitive against that of the offline scheduler that knows all jobs in advance.We consider two models based on the maximum delay that can be allowed between the arrival and scheduling of a job. In the first, a job can be scheduled anytime after its arrival; in the second a job is lost unless scheduled immediately upon arrival, preempting a currently running job if needed. The two settings correspond to two natural models of how long an advertiser retains interest in a relevant user. We show that there is, in fact, a sharp separation between what an online scheduler can achieve in these two settings. In the first setting with no deadlines, we give a natural deterministic algorithm with a constant competitive ratio against the offline scheduler. In contrast, we show that in the sharp deadline setting, no (deterministic or randomized) online algorithm can achieve better than a polylogarithmic ratio.
An intact and functional soluble form of the insulin receptor is secreted by cultured cells. (1993)

We have recently reported that the insulin receptor (IR), a tetrameric transmembrane protein located on the surface of target cells, is present as a soluble form in human plasma. In the present study we investigated whether human cells in culture release an intact and functional form of the IR. We found that IRs are secreted into the incubation medium by four cell lines (IM-9 human lymphoblasts, MCF-7 human breast cancer cells, HepG2 human hepatoma cells, and 3T3 mouse fibroblasts transfected with human IRs). IR secretion was further characterized in IM-9 cells. IR release was time, temperature, and energy dependent, and enhanced by incubation with insulin. The dilution slope of secreted IRs in a specific IR RIA was parallel to that produced by highly purified human placenta IRs. Ligand binding studies revealed that secreted receptors bound insulin with high affinity, and the Scatchard analysis revealed two orders of binding sites (the high affinity site had a dissociation constant of 0.32 +/- 0.08 nM). Analysis of secreted receptors by sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated a molecular size of 135 kilodaltons for the alpha-subunit and 95 kilodaltons for the beta-subunit. Other experiments indicated that the beta-subunit tyrosine kinase activity of the secreted receptor was stimulated by insulin. These studies indicate, therefore, that a soluble, intact, and functional IR is secreted by cultured cells, and that this soluble protein could be involved in certain insulin-mediated functions, such as receptor down-regulation.
Using Behavioral Interactions from a Mobile Device to Classify the Reader's Prior Familiarity and Goal Conditions (2020)

A student reads a textbook to learn a new topic; an attorney leafs through familiar legal documents. Each reader may have a different goal for, and prior knowledge of, their reading. A mobile context, which captures interaction behavior, can provide insights about these reading conditions. In this paper, we focus on understanding the different reading conditions of mobile readers, as such an understanding can facilitate the design of effective personalized features for supporting mobile reading. With this motivation in mind, we analyzed the reading behaviors of 285 Mechanical Turk participants who read articles on mobile devices with different familiarity and reading goal conditions. The data was collected non-invasively, only including behavioral interactions recorded from a mobile phone in a non-laboratory setting. Our findings suggest that features based on touch locations can be used to distinguish among familiarity conditions, while scroll-based features and reading time features can be used to differentiate between reading goal conditions. Using the collected data, we built a model that can predict the reading goal condition (67.5%) significantly more accurately than a baseline model. Our model also predicted the familiarity level (56.2%) marginally more accurately than the baseline. These findings can contribute to developing an evidence-based design of reading support features for mobile reading applications. Furthermore, our study methodology can be easily expanded to different real-world reading environments, leaving much potential for future investigations.
A Bright Single Photon Source Based on a Diamond Nanowire (2009)

The development of a robust light source that emits one photon at a time is an outstanding challenge in quantum science and technology. Here, at the transition from many to single photon optical communication systems, fully quantum mechanical effects may be utilized to achieve new capabilities, most notably perfectly secure communication via quantum cryptography. Practical implementations place stringent requirements on the device properties, including stable photon generation, room temperature operation, and efficient extraction of many photons. Single photon light emitting devices based on fluorescent dye molecules, quantum dots, and carbon nanotube material systems have all been explored, but none have simultaneously demonstrated all criteria. Here, we describe the design, fabrication, and characterization of a bright source of single photons consisting of an individual Nitrogen-vacancy color center (NV center) in a diamond nanowire operating in ambient conditions. The nanowire plays a positive role in increasing the number of single photons collected from the NV center by an order of magnitude over devices based on bulk diamond crystals, and allows operation at an order of magnitude lower power levels. This result enables a new class of nanostructured diamond devices for room temperature photonic and quantum information processing applications, and will also impact fields as diverse as biological and chemical sensing, opto-mechanics, and scanning-probe microscopy.