gebhart/patrepeval huggingface dataset:
Crystal state and solution conformation of the B blood group trisaccharide α‐l‐Fucp‐(1→2)‐[α‐d‐Galp]‐(1→3)]‐β‐d‐Galp‐OCH3 (1999)

The crystal structure of the human B blood group related trisaccharide α‐ l ‐Fuc p ‐(1→2)‐[α‐ d ‐Gal p ]‐(1→3)‐β‐ d ‐Gal p ‐OCH 3 ( 1 ) has been determined. The solution structure of 1 was studied by two‐dimensional NMR techniques at 600 MHz in D 2 O solution and the conformational properties were analyzed in terms of the torsional angles φ H and ψ H , derived from 3 J CH coupling constants, and 10 inter‐ residue proton–proton distances. 3 J CH could be accurately measured by a recently introduced two‐dimensional heteronuclear correlation experiment (EXSIDE). The nuclear Overhauser enhancement‐derived distances and the calculated torsion angles were compared with the same information available from the crystal structure. The agreement is excellent, indicating that the trisaccharide adopts a restricted conformation in solution, which was also predicted by the Hard Sphere Exo‐Anomeric forcefield. The data of 1 are complemented by NMR studies of the closely related α‐ l ‐Fuc p ‐(1→2)‐[6‐deoxy‐α‐ d ‐Gal p ]‐(1→3)‐β‐ d ‐Gal p O ‐(CH 2 ) 7 CH 3 trisaccharide ( 2 ).
Development of 3D System-in-Package with TSV Technology (2014)

In recent years, products such as smart phones, tablets, and wearable devices, are becoming miniaturized and high performance. 3D-type semiconductor structures are advancing as the demand for high-density assembly increases. We studied a fabrication process using a SoC die and a memory die for 3D-SiP (System in Package) with TSV technology. Our fabrication is comprised of two processes. One is called MEOL (Middle End of Line) for exposing and completing the TSV's in the SoC die, and the other is assembling the SoC and memory dice in a 3D stack. The TSV completion in MEOL was achieved by SoC wafer back-side processing. Because its final thickness will be a thin 50μm (typical), the SoC wafer (300 mm diameter) is temporarily attached face-down onto a carrier-wafer. Careful back-side grinding reveals the “blind vias” and fully opens them into TSV's. A passivation layer is then grown on the back of the wafer. With planarization techniques, the via metal is accessed and TSV pads are built by electro-less plating without photolithography. After the carrier-wafer is de-bonded, the thin wafer is sawed into dice. For assembling the 3D die stack, flip-chip technology by thermo-compression bonding was the method chosen. First, the SoC die with copper pillar bumps is assembled to the conventional organic substrate. Next the micro-bumps on the memory die are bonded to the TSV pads of the SoC die. Finally, the finished assembly is encapsulated and solder balls (BGA) are attached. The 3D-SiP has passed both package-level reliability and board-level reliability testing. These results show we achieved fabricating a 3D-SiP with high interconnect reliability.
Parallel Acquisition of Multiple Images Using Coherence Gating in Off-Axis Dark-Field Digital Holographic Microscope for Semiconductor Metrology (2020)

We present an Off-Axis dark-field digital holographic microscope capable of parallel acquisition of multiple holograms. With this microscope we aim to measure overlay (OV) with sub-nanometer precision and milli-second acquisition times over large wavelength range.
Nanoindentation of silicon implanted with hydrogen: effect of implantation dose on silicon’s mechanical properties and nanoindentation-induced phase transformation (2017)

Implantation of hydrogen in single-crystal silicon (c-Si) is known to affect its machining. However, very little is reported on the material and mechanical properties of hydrogen-implanted silicon (Si). In this article, near-surface regions (∼0-500 nm) of lightly doped (1 0 0) Si were modified by varying the hydrogen concentration using ion implantation. The maximum hydrogen concentration was varied from ∼4 × 1020 to ∼3.2 × 1021 cm-3. The implanted Si was investigated by nanoindentation. From the dynamic nanoindentation test, it was found that in hydrogen-implanted Si hardness is increased significantly, while the elastic modulus is reduced. The nanoindentation-induced Si phase transformation was studied under different load/unload rates and loads. Raman spectroscopy revealed that the hydrogen implantation tends to suppress Si-XII and Si-III phases and facilitates amorphous Si formation during the unloading stage of nanoindentation. Both the mechanical properties and phase transformations were qualitatively related not only to the hydrogen concentration, but also to the implantation-generated defects and strain.
Signaling architecture and protocols for the Next Generation Network (2009)

ITU-T (International Telecommunication Union, Telecommunication Standardization Sector) made remarkable achievement in international standardization of the Next Generation Network (NGN) during the last Study Period (2005∼2008). This paper gives a brief overview and functional architecture of ITU-T NGN, and presents signaling architecture and protocols for the ITU-T NGN.
Alkali Cold Gelation of Whey Proteins. Part II: Protein Concentration (2009)

The effect of the whey protein isolate (WPI) concentration on the sol-gel-sol transition in alkali cold gelation was investigated at pH 11.6-13 using oscillatory rheometry. The elastic modulus increases quickly with time to reach a local maximum (G'max), followed by a degelation step where the modulus decreases to a minimum value (G'min). Depending on the pH, a second gelation step will occur. At the end of the first gelation step around G'max, the system fulfilled the Winter-Chambon criterion of gelation. The analysis of the maximum moduli with the protein concentration shows that (i) there is a percolation concentration above which an elastic response is observed (approximately 6.8 wt %); (ii) there are two concentration regimes for G''max and G''max above this concentration, where we have considered power-law and percolation equations; (iii) there is a crossover concentration between the two regimes (at approximately 8 wt %) for both G'max and G''max when both moduli are equal, and this value is constant under all conditions tested (G'max=G''max approximately 4 Pa). Therefore, alkali cold gelation is better represented using two concentrations regimes than one, as observed for other biopolymers.
Towards a better control of plasma polymerization: a case study of plasma produced polyaniline (2020)

International audience
Immunodominant antigens of Actinobacillus actinomycetemcomitans serotype b in early‐onset periodontitis patients (1992)

Previous work with Actinobacillus actinomycetemcomitans strain Y4 (serotype b) indicates that the immunodominant antigen in high-responding patients (top 10%, 80% of which were black) is the serotype-specific antigen. In this study we examined the immunodominant antigens of A. actinomycetemcomitans strain Y4 in both black and white patients having a range of antibody titers. We sought to test the hypothesis that the immunodominant antigen in these subjects was the same antigen found in high responders. Seropositive white early-onset periodontitis (EOP) patients were selected from 99 EOP patients. Black subjects were then selected with comparable antibody titers. Double immunodiffusion and competition assays were used to determine whether reactive antibodies were A. actinomycetemcomitans serotype b-specific or whether the response was to serotype a or c. The immunodominant antigens were then determined for the patients reacting specifically to A. actinomycetemcomitans Y4 using limiting dilution analysis on Western blots. The immunodominant antigen for the A. actinomycetemcomitans Y4-specific patients appeared to be the serotype-specific carbohydrate for most subjects (19/20 or 95%, including: 13/14 black and 6/6 white patients). In conclusion, the immunodominant antigen for A. actinomycetemcomitans Y4 was the serotype-specific carbohydrate regardless of antibody titer for both black and white specifically reactive patients.
Crystal structure of Tetracyclo[5,3,1,12,6,04,9]dodecane (iceane) (1977)

The crystal structure of the title compound, C12H18, has been determined at 295 K by X-ray diffraction and refined by full-matrix least squares to a residual of 0.049 for 216 ?observed? reflections; molecular geometry has been corrected for the effects of thermal motion using a rigid body approximation. Crystals are hexagonal, P63/m, a = 6.582(1), c = 11.843(3) Ǻ, Z = 2, the molecules occupying a hexagonal close- packed array.
Assessing methods and obstacles in chemical space exploration (2020)

Abstract Benchmarking the performance of generative methods for drug design is complex and multifaceted. In this report, we propose a separation of concerns for de novo drug design, categorizing the task into three main categories: generation , discrimination and exploration . We demonstrate that changes to any of these three concerns impacts benchmark performance for drug design tasks. In this report, we present Deriver, an open‐source Python package that acts as a modular framework for molecule generation, with a focus on integrating multiple generative methods. Using Deriver, we demonstrate that changing parameters related to each of these three concerns impacts chemical space traversal significantly, and that the freedom to independently adjust each is critical to real‐world applications having conflicting priorities. We find that combining multiple generative methods can improve optimization of molecular properties and lower the chance of becoming trapped in local minima. In addition, filtering molecules for drug‐likeness (based on physicochemical properties and SMARTS pattern matching) before they are scored may hinder exploration, but can also improve the quality of the final molecules. Finally, we demonstrate that any given task has an exploration algorithm best suited to it, though in practice linear probabilistic sampling generally results in the best outcomes, when compared to Monte Carlo sampling or greedy sampling. Deriver is being made freely available, to help others interested in collaboratively improving existing methods in de novo drug design centered around inheritance of molecular structure, modularity, extensibility, and separation of concerns.
Editorial and changes to the Editorial Board (2012)

Our editorial board continues to perform outstanding service to the mobile computing community, and for this we are very grateful. The board has evolved this year, and we take this opportunity to welcome several new Associate Editors: Prithwish Basu, Carla Fabiana-Chiasserini, Ahmed Helmy, Vana Kalogeraki, Richard J. La, Xiang-Yang Li, Cecilia Mascolo, Tommaso Melodia, Guevara Noubir, Andrea Richa, Lakshminarayanan Subramanian, Karthikeyan Sundaresan, Xinbing Wang, Edmund Yeh, Yanyong Zhang, and Lin Zhong. Biographies are provided. They collectively strengthen our expertise in disruption-tolerant networking, vehicular networks, mobile computing systems, wireless security, mobile social networks, wireless network optimization, game theory, cognitive radios, and information theory. We are excited to have them on board and thank them for agreeing to serve. Finally, we'd also like to acknowledge several Associate Editors whose terms recently expired: Tajana Simunic-Rosing, Sajal Das, Paolo Santi, Terry Todd, Wade Trappe, Nalini Venkatasubramanian, Mary Ann Ingram, Ekram Hossain, Chiara Petrioli, Alex Snoeren, Prasant Mohapatra, and Yunhao Liu. This very distinguished group of researchers has contributed greatly to increasing the journal's quality and reputation, and they will be missed! We wish them the best in their future endeavors.
A cationic benzocorrole Cu(ii) complex as a highly stable antiaromatic system (2020)

Here we report a highly stable 16π-electron antiaromatic system based on the ligand-oxidized Cu(ii)-tetrabenzocorrole. The antiaromaticity of the monocationic corrole complex was elucidated with the unique bond length alternation pattern of the crystal structure and the spectral diagnostic features. The NICS and GIMIC calculations clearly depicted its inner 15-membered-ring main pathway with a strong paratropic ring current.
Asymmetric dual-band UWB / 60 GHz demonstrator (2008)

This paper describes a pragmatic approach on the up-conversion of WiMedia compliant UWB signals into the 60 GHz band. This dual band concept is based on propagation measurements at {3.1-10.6} and 60 GHz. Due to stringent frequency regulation, UWB systems operating in the 3.1 to 10.6 GHz bands are both bandwidth limited and power limited. Therefore, many potential users hesitate to deploy this technology. Up-conversion to the 60 GHz band and enhanced baseband parameters can make UWB technology more reliable and hence, more attractive. An experimental system based on a commercially available UWB development kit and IHPpsilas 60 GHz chip-set has been developed. The system architecture is described. Measurement results indicate that this combination may be interesting for many applications.
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology (2017)

Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family is ribonuclease 1 (RNase 1). Understanding the physiological roles of RNase 1 is becoming increasingly important, as engineered forms of the enzyme progress through clinical trials as chemotherapeutic agents for cancer. Here, we present an in-depth biochemical characterization of RNase 1 homologs from a broad range of mammals (human, bat, squirrel, horse, cat, mouse, and cow) and nonmammalian species (chicken, lizard, and frog). We discover that the human homolog of RNase 1 has a pH optimum for catalysis, ability to degrade double-stranded RNA, and affinity for cell-surface glycans that are distinctly higher than those of its homologs. These attributes have relevance for human health. Moreover, the functional diversification of the 10 RNase 1 homologs illuminates the regulation of extracellular RNA and other aspects of vertebrate evolution.
Antenna coupling in multi active multi passive port topologies (2012)

The electromagnetic (EM) coupling between pairs of antennas in a system comprised of μ active RF ports and M passive ones is expressed under arbitrary complex terminations by obtaining the effective transfer function between the active ports using Mason's rule. Unlike a previous approach where the mutual impedance matrix of N+M dimensions is collapsed to N dimensions, the proposed approach directly estimates the effective coupling from the reference scattering parameters and the complex terminations.
Sequestration of U(VI) from Acidic, Alkaline, and High Ionic-Strength Aqueous Media by Functionalized Magnetic Mesoporous Silica Nanoparticles: Capacity and Binding Mechanisms (2017)

Uranium(VI) exhibits little adsorption onto sediment minerals in acidic, alkaline or high ionic-strength aqueous media that often occur in U mining or contaminated sites, which makes U(VI) very mobile and difficult to sequester. In this work, magnetic mesoporous silica nanoparticles (MMSNs) were functionalized with several organic ligands. The functionalized MMSNs were highly effective and had large binding capacity for U sequestration from high salt water (HSW) simulant (54 mg U/g sorbent). The functionalized MMSNs, after U exposure in HSW simulant, pH 3.5 and 9.6 artificial groundwater (AGW), were characterized by a host of spectroscopic methods. Among the key novel findings in this work was that in the HSW simulant or high pH AGW, the dominant U species bound to the functionalized MMSNs were uranyl or uranyl hydroxide, rather than uranyl carbonates as expected. The surface functional groups appear to be out-competing the carbonate ligands associated with the aqueous U species. The uranyl-like species were bound with N ligand as η<sup>2</sup> bound motifs or phosphonate ligand as a monodentate, as well as on tetrahedral Si sites as an edge-sharing bidentate. The N and phosphonate ligand-functionalized MMSNs hold promise as effective sorbents for sequestering U from acidic, alkaline or high ionic-strength contaminated aqueous media.
Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent (1996)

Mice with a targeted disruption of RelB, a member of the Rel/NF-kappaB family of transcription factors, have multifocal, mixed inflammatory cell infiltration in several organs, myeloid hyperplasia, and splenomegaly due to extramedullary hemopoiesis. To elucidate the cellular requirements for this complex phenotype, we have bred RelB-deficient (RelB(kappaO)) animals to two strains of immunodeficient mice, recombinase-activating gene-1-deficient (RAG-1(kappaO), lacking B and T cells), and Nur77/N10-transgenic mice (Nur77/N10(TG), lacking only T cells). We also generated mutant mice deficient in both RelB and the p50 subunit of NF-kappaB (p50(kappaO), multiple defects in B cell function). RelB(kappaO)RAG-1(kappaO) and RelB(kappaO)Nur77/N10(TG) mice are disease-free, while RelB(kappaO)p50(kappaO) double-mutant animals develop an even more severe phenotype despite the absence of B cells in the inflammatory infiltrates. Thus, both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent, whereas B cells are not crucially involved.
Boratabenzene Complexes of Cr(III) (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTBoratabenzene Complexes of Cr(III)Jonathan S. Rogers, Xianhui Bu, and Guillermo C. BazanView Author Information Department of Chemistry University of California Santa Barbara, California 93106 Cite this: J. Am. Chem. Soc. 2000, 122, 4, 730–731Publication Date (Web):January 15, 2000Publication History Received17 September 1999Published online15 January 2000Published inissue 1 February 2000https://doi.org/10.1021/ja993378+Copyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views547Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (55 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Catalysts,Ethylene polymerization,Hydrocarbons,Ligands,Reactivity Get e-Alerts
Bursal Acromial Reconstruction (BAR) Using an Acellular Dermal Allograft as a Surgical Solution for the Treatment of Massive Irreparable Rotator Cuff Tears (2021)

Massive, irreparable rotator cuff tears in patients without severe signs of osteoarthritis remains a major challenge for orthopaedic surgeons. These can be a source of significant pain and functional loss occurring most commonly in a relatively frail, elderly patient population. A plethora of surgical techniques covering minimally invasive, arthroscopic techniques and open, salvage procedures have been described for this challenging patient cohort. Continuous evolvement of arthroscopic techniques has led to all-arthroscopic superior capsular reconstruction techniques using allografts, thereby reducing donor side morbidity along with decreased soft tissue dissection. However, conventional superior capsular reconstruction is noted to be a technically complex, time-consuming, and high-cost surgery, which may put this technique beyond the confidence of many shoulder surgeons. The subacromial balloon spacer has emerged as a potential solution in these patients, providing interposition between the humeral head and acromion. However, the subacromial balloon biodegrades rapidly and its effect is only temporary. Thus this technique article presents using an acellular human dermal allograft to reconstruct the bursal layer, which is normally interposed between the humeral head and the acromion. The proposed technique provides a permanent interposition graft preventing humeral acromial contact, which does not undergo rapid biodegradation. The surgical technique is technically feasible, both minimizing surgical time and therefore operative risk to the patient.
Biofabrication of Chitosan-Based Nanomedicines and Its Potential Use for Translational Ophthalmic Applications (2020)

Drug delivery to the anterior and posterior segment of eye remains a challenge. Nanoparticle-mediated drug delivery has indicated some promise. The presented review aims to summarize recent advancements in chitosan-based nanotherapies for ocular drug delivery and the challenges encountered during the process. Significant research using chitosan, a cationic linear polymer, is being conducted for ocular drug delivery. A vast number of publications exploit the mucoadhesive properties of the polymer, which arise due to interactions between the amino acids of chitosan and the sialic acid residues in mucous. The high degree of crosslinking in chitosan nanoparticles facilitates a dramatic increase in ocular drug retention of the desired drug, which subsequently helps in ocular penetration and improving the bioavailability of the drugs. A noted decrease in the initial burst of the drug is the basis for developing sustained drug release formulation using biodegradable and biocompatible chitosan polymer. In vitro as well as in vivo studies have indicated enhancement in the uptake, accumulation, and removal of chitosan nanoparticles from the site of delivery. In summary, chitosan- or modified-chitosan-based nanoparticles are being widely tested as drug carriers for treatment of bacterial and viral infections, glaucoma, age-related macular degeneration, and diabetic retinopathy.
Evaluation of diagnostic assays for the serological detection of Actinobacillus pleuropneumoniae on samples of known or unknown exposure (2013)

Accurate diagnosis of exposure to Actinobacillus pleuropneumoniae is important for maintaining negative farms. In the present study, the ability of a dual-plate complement fixation (CF) assay and 3 commercially available enzyme-linked immunosorbent assays (ELISAs; quad-plate ELISA-1, single-plate ELISA-2, and single-plate ELISA-3) in detecting serological evidence of A. pleuropneumoniae exposure was compared using serum samples of experimentally infected or vaccinated pigs, or field samples from the United States. Forty-two pigs were divided into groups of 2 pigs and were inoculated with 1 of 15 A. pleuropneumoniae strains representing all known serovars of A. pleuropneumoniae, or with Actinobacillus suis, or were vaccinated with a bacterin containing A. pleuropneumoniae serovar 1, 3, 5, or 7. Serum samples collected at the day of inoculation or vaccination and 7, 14, 21, and 28 days later were used to compare the assays. On samples from experimentally infected pigs, the dual-plate CF assay, quad-plate ELISA-1, single-plate ELISA-2, and single-plate ELISA-3 had sensitivities of 0.46, 0.74, 0.13, and 0.13 and specificities of 0.90, 1.0, 1.0, and 1.0, respectively. Vaccinated pigs were identified only by the dual-plate CF assay and the quad-plate ELISA-1. In addition, 90 serum samples with unknown A. pleuropneumoniae exposure collected under field conditions were tested with all assays. The agreement of the 4 assays on field samples was slight to fair. While several assays are available for demonstration of A. pleuropneumoniae exposure, differences in assay targets complicate test choices. Decisions on which assay or combination of assays to use depend on the specific reasons for running the assays.