gebhart/patrepeval huggingface dataset:
Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients (2022)

Based on our data, patients with non-BRCA1-like TNBC appear to benefit from the addition of capecitabine to adjuvant chemotherapy. Patients with BRCA1-like TNBC may also benefit. Additional research is needed to define the subgroup within BRCA1-like TNBC patients who may not benefit from adjuvant capecitabine.
The Formation of Poliovirus Proteins (1969)

Cleavage of peptide bonds plays an important role in the formation of certain proteins. The classic case is zymogen activation, but the more recent finding that the 2-chain molecule of insulin is formed by removal of a large segment from the center of a single polypeptide (Chance, Ellis, and Bromer, 1968) suggests that proteolysis may have a more widespread role in protein formation than had previously been imagined.
Modelling stored product ecosystems using the postharvest aeration and storage simulation tool (PHAST) with realistic boundary conditions. (2003)

<title>Abstract</title> A previously developed finite-element model of the heat, mass and momentum transfer during aerated and non-aerated grain storage was used to investigate the traditional theory of moisture migration (i.e. the movement of excessive moisture in a grain mass during non-aerated storage, which can lead to spoilage). Very little moisture accumulation at the exposed top surface of the bulk (less than 0.1 percentage points) was predicted for a non-aerated bin with a diameter of 5.5 m and an eave height of 11.0 m in Indianapolis, Indiana, USA, during 12 months of storage. The model used permeable boundaries that allowed natural convection currents to originate and flow into the headspace and plenum air. It was determined that moisture "migration" in the traditional sense did not occur. Instead, a more realistic theory of moisture equilibration between the grain mass and headspace and plenum air was developed. Moisture accumulation in the upper portions of a grain mass occurred primarily due to natural convection currents that entered and exited the headspace. By controlling the equilibrium relative humidity of the headspace, moisture accumulation at the grain surface of a bin could be minimized.
Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 4 1) : Variation of the Basic Structure (2000)

A range of 11 derivatives of flavone-8-acetic acid (FAA) in which the structure has been substantially altered in different ways have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. The generally poor activity observed shows that the basic structure cannot be altered much without destroying the activity.
COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models (2014)

Antiangiogenic agents that block vascular endothelial growth factor (VEGF) signaling are important components of current cancer treatment modalities but are limited by alternative ill-defined angiogenesis mechanisms that allow persistent tumor vascularization in the face of continued VEGF pathway blockade. We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. PGE2 production in preclinical breast and colon cancer models was tightly controlled by cyclooxygenase-2 (COX-2) expression, and COX-2 inhibition augmented VEGF pathway blockade to suppress angiogenesis and tumor growth, prevent metastasis, and increase overall survival. These results demonstrate the importance of the COX-2/PGE2 pathway in mediating resistance to VEGF pathway blockade and could aid in the rapid development of more efficacious anticancer therapies.
Linear model predictive control for lane keeping and obstacle avoidance on low curvature roads (2013)

This paper presents a control architecture based on a linear MPC formulation that addresses the lane keeping and obstacle avoidance problems for a passenger car driving on low curvature roads. The proposed control design decouples the longitudinal and lateral dynamics in two successive stages. First, plausible braking or throttle profiles are defined over the prediction horizon. Then, based on these profiles, linear time-varying models of the vehicle lateral dynamics are derived and used to formulate the associated linear MPC problems. The solutions of the optimization problems are used to determine for every time step, the optimal braking or throttle command and the corresponding steering angle command. Simulations show the ability of the controller to overcome multiple obstacles and keep the lane. Experimental results on an autonomous passenger vehicle driving on slippery roads show the effectiveness of the approach.
Transfer Learning and Meta Learning-Based Fast Downlink Beamforming Adaptation (2020)

This article studies fast adaptive beamforming optimization for the signal-to-interference-plus-noise ratio balancing problem in a multiuser multiple-input single-output downlink system. Existing deep learning based approaches to predict beamforming rely on the assumption that the training and testing channels follow the same distribution which may not hold in practice. As a result, a trained model may lead to performance deterioration when the testing network environment changes. To deal with this task mismatch issue, we propose two offline adaptive algorithms based on deep transfer learning and meta-learning, which are able to achieve fast adaptation with the limited new labelled data when the testing wireless environment changes. Furthermore, we propose an online algorithm to enhance the adaptation capability of the offline meta algorithm in realistic non-stationary environments. Simulation results demonstrate that the proposed adaptive algorithms achieve much better performance than the direct deep learning algorithm without adaptation in new environments. The meta-learning algorithm outperforms the deep transfer learning algorithm and achieves near optimal performance. In addition, compared to the offline meta-learning algorithm, the proposed online meta-learning algorithm shows superior adaption performance in changing environments.
A potential individual cell malignancy indicator: focal length (2011)

The label-free technique of optofluidic intracavity spectroscopy (OFIS) utilizes the optical transmission spectrum of a cell in a microfluidic Fabry-P&#233;rot (F-P) cavity to distinguish cells from cancerous cell lines and baseline normal blood cells. The classification between canine hemangiosarcoma (HSA) cancer cells and monocytes in canine normal peripheral blood mononuclear cells (PBMCs) had been demonstrated with 95% sensitivity and 98% specificity. Now with a new optical model that treats the cell settled at the bottom of the cavity as a thin lens, the focal length of cells was extracted and used as an individual cell malignancy indicator.
New concept of power based pole slip protection for dispersed generators in smart grid environment (2012)

The paper presents a new pole slipping protection method that combines high efficiency of pole slip detection and sensitivity to many sources of potential pole slipping. To simplify the setup process the adaptive settings are calculated continuously. The new adaptive method utilizes active and reactive power measurements on machine terminals to ascertain that the synchronous machine is committed to pole slips. In doing so, it offers the capability of detecting pole slips even before it occurs (predictive features). During the method investigation the main efforts have been focused on the development of new protection techniques, which should ensure better (faster and more selective than currently known) detection of loss of synchronism in a synchronous machine. In the article a new approach to pole slipping protection and exemplary results are presented. The method has been successfully tested with utilization of data from simulation as well as signals from the laboratory of real synchronous machines.
Differential effects of BQ‐123 against endothelin‐1 and endothelin‐3 on the rat vas deferens: evidence for an atypical endothelin receptor (1993)

1. Endothelin-1 and endothelin-3 enhanced concentration-dependently the rat vas deferens twitch response to electrical stimulation, endothelin-1 being three times more potent. Sarafotoxin S6c was at least 200 times less active than endothelin-1. 2. The response to endothelin was antagonized in a competitive manner by the supposedly selective ETA receptor antagonist, BQ-123 (pA2:7.0 +/- 0.1). In contrast, the endothelin-1 concentration-response curve was only shifted two fold in the presence of 10 microM BQ-123, while no effect was observed at 1 microM. 3. This evidence suggests the rat vas deferens contains an endothelin receptor not conforming to the ETA/ETB receptor subtype classification so far proposed.
Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy (2021)

Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model. Four treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP + NP THY. The results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn’t hinder the antitumor activity of CISP as shown by tumour weight and histological examination data. In conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy.
Asphaltene Nanoaggregates Measured in a Live Crude Oil by Centrifugation (2009)

Asphaltene nanoaggregates have recently been observed in live crude oil by observation of gravitationally induced asphaltene gradients in four different reservoir sands with oil columns up to 1000 m vertical. When the liquid phase is invariant, these gradients can be fit using Archimedes buoyancy in the Boltzmann distribution; the only adjustable parameter in data fitting is the size of the asphaltene nanoaggregate; ∼2 nm is obtained in four reservoir sands and is similar to laboratory results for asphaltene nanoaggregates in toluene. Here, a live crude oil (with dissolved gases) has been spun at modest g forces for long times designed to create a large, equilibrium asphaltene gradient for the presumed 2 nm aggregates. Elevated temperatures (∼91 °C) were employed during centrifugation to mimic reservoir conditions for asphaltene aggregation and prevention of a possible wax phase. Elevated pressures were employed on the hot, live crude oil to maintain dissolved gas concentrations. A total of 13 alliquots of crude oil were removed after centrifugation, and the asphaltene concentrations were determined by optical spectroscopy. Indeed, a large asphaltene gradient was observed, and a 2.6 nm diameter nanoaggregate was obtained using Archimedes buoyancy in the Boltzmann distribution. In addition, a solubility model accounting for the gas/oil ratio (GOR) gradient was used to analyze the asphaltene gradient, giving an asphaltene particle size of 2.0 nm, thus, the same as field observations. In addition, the gradient in bulk resins was shown to be quite small, showing the stark contrast of asphaltene versus bulk resin aggregation. The heaviest resins (or lightest asphaltenes) do show some gradient. These observations allow for the determination of the maximum and minimum asphaltene aggregation number; the range is roughly 3−8. Some modest resin association with asphaltenes, one resin molecule in every asphaltene nanoaggregate, is consistent with our data. These results are discussed within the increasingly successful modified Yen model of asphaltenes.
Vibration-insensitive interferometric measurements of mirror surface figures under cryogenic conditions (2003)

We report on a technique to measure the surface figure of mirrors under extreme vibrational conditions. Measurements are presented of the surface figure changes of Zerodur primary mirrors with both spherical and parabolic shapes, manufactured for the NASA Deep Impact program. Conditions ranged from room temperature to 130K. The interferometer was located outside the cryogenic vacuum chamber and did not require any active or passive vibration isolation. We show measurement repeatability of better than 1/500 waves RMS at 633nm.
Circularly polarised periodic leaky‐wave antenna with filtering capability (2018)

A planar periodic leaky‐wave antenna with filtering capability, circular polarisation, and wideband performance is presented. Seamless beam scanning from backward to forward is provided by self‐matching the unit cell of the antenna over a large frequency band from 22 to 28 GHz. A wide scanning range of 84° is achieved by using a relatively low‐permittivity dielectric material. Filtering capability is embedded in the antenna structure which contributes to the minimisation of the overall circuit size which is aimed in recent millimetre‐wave antenna in package systems. The proposed antenna has a circular polarisation with an axial ratio of &lt;2 dB at broadside which makes it a good candidate for peer‐to‐peer and peer‐to‐multipeer communication systems.
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19 (2022)

We identified preinfusion biomarkers that can be used to predict severe CRS with a sensitivity, specificity, and accuracy superior to the current gold standard of disease burden. We demonstrated the fundamental role of the IFNγ pathway in driving CRS, suggesting CRS and carHLH are overlapping rather than distinct phenomena, an observation with important treatment implications. We identified IL18 as a possible targetable cytokine in ICANS, providing rationale for IL18 blocking therapies to be translated into clinical trials in ICANS.
Module-Level Polaritonic Thermophotovoltaic Emitters via Hierarchical Sequential Learning (2023)

Thermophotovoltaic (TPV) generators provide continuous and high-efficiency power output by utilizing local thermal emitters to convert energy from various sources to thermal radiation matching the bandgaps of photovoltaic cells. Lack of effective guidelines for thermal emission control at high temperatures, poor thermal stability, and limited fabrication scalability are the three key challenges for the practical deployment of TPV devices. Here we develop a hierarchical sequential-learning optimization framework and experimentally realize a 6″ module-scale polaritonic thermal emitter with bandwidth-controlled thermal emission as well as excellent thermal stability at 1473 K. The 300 nm bandwidth thermal emission is realized by a complex photon polariton based on the superposition of Tamm plasmon polariton and surface plasmon polariton. We experimentally achieve a spectral efficiency of 65.6% (wavelength range of 0.4-8 μm) with statistical deviation less than 4% over the 6″ emitter, demonstrating industrial-level reliability for module-scale TPV applications.
Spectrally shaped rare-earth-doped fiber ASE sources for use in optical coherence tomography (1996)

Summary form only given. Optical coherence tomography (OCT) has proven over the past few years to be a powerful new optical imaging modality. OCT uses interferometric detection and a short-coherence-length light source to achieve high sensitivity, high-dynamic range, and high resolution (1-10 /spl mu/m). Biomedical applications include ophthalmology, microscopy, endoscopy, laproscopy, dermatology, developmental biology, dentistry etc. One of the key components in OCT systems is the optical source. This paper presents preliminary results on the use of spectrally flattened rare-earth-doped fiber ASE source in OCT systems. Rare-earth-doped fibers are a very promising candidate for future OCT systems. The authors expect spectrally shaped rare earth-doped fiber ASE sources to play an important role in future OCT systems. In the near future, source powers in excess of 100 mW and coherence lengths under 10 cm should be available at a variety of wavelengths. The authors review some of the design details on this Nd source, quantify its optical parameters power, bandwidth, blindness, etc.), and present its application in tomographic biomedical imaging (e.g. skin and bone structure). The authors also compare its performance with other types of sources such as: semiconductor sources (light-emitting diodes, edge-emitting diodes, superluminescent diodes), model-lock lasers, and supercontinuum sources.
Applying the Kano model and QFD to explore customers' brand contacts in the hotel business: A study of a hot spring hotel (2011)

Brand contacts are a variety of elements about how customers come into contact with a brand and how they communicate their values about it to other potential customers. For the sake of cost and efficiency, brand contacts can be investigated not only from a customer perspective but also from that of the service provider. This paper thus attempts to integrate the Kano model and quality function deployment (QFD) to explore brand contact elements. The results gained from an empirical study of a hot spring hotel indicate that customers' perceptions about contact elements are mostly classified into one-dimensional and must-be attributes by the Kano model. The proposed approach contributes to the creation of attractive contact elements that have an enormous potential to further increase customer satisfaction and differentiate competitors. Moreover, along with the 10 technical characteristics obtained by the integrated approach, the customers' contact experiences are displayed through the brand contact priority grid, both of which provide references for future hotel business development. Lastly, atmosphere-oriented brand contacts dominate customers' brand perceptions more than others, in that they lessen customers' sense of risk and uncertainty toward product/service offerings. A discussion of the findings including managerial implications is also presented in this paper.
Columnar self-assembly of N,N′,N′′-trihexylbenzene-1,3,5-tricarboxamides investigated by means of NMR spectroscopy and computational methods in solution and the solid state (2017)

The columnar self-assembly resulting from units of N,N',N''-trihexylbenzene-1,3,5-tricarboxamide is investigated in solution and the solid state by means of NMR spectroscopy. A parallel computational study utilizing both semiempirical and DFT methods allows comparison between experimental results and calculated data for self-assembled and non-assembled structural hypotheses. The hybrid functional B3LYP is compared with the B3LYP-D and B97D functionals to assess contributions due to dispersion interactions. Interatomic distances are studied utilizing ROE experiments on proton spins in solution. Isotropic shifts as measured experimentally are shown to offer a method to assess the self-assemblies 'on-the-fly'. The anisotropic part of the shift interaction for carbon nuclei is probed in the solid state with specific magic-angle spinning experiments. The sensitivity of the NMR parameters for various carbon environments with respect to the orientation of the substituents and packing effects is investigated computationally. We show that all the utilized experimental techniques, in both solution and the solid state, and in combination with DFT calculations, are capable of discerning between assembled and non-assembled systems and offer a robust set of independent tools to highlight atomic details in self-organized structures.
Improving 64-bit Java IPF performance by compressing heap references (2004)

64-bit processor architectures like the Intel/spl reg/ Itanium/spl reg/ processor family are designed for large applications that need large memory addresses. When running applications that fit within a 32-bit address space, 64-bit CPUs are at a disadvantage compared to 32-bit CPUs because of the larger memory footprints for their data. This results in worse cache and TLB utilization, and consequently lower performance because of increased miss ratios. This paper considers software techniques for virtual machines that allow 32-bit pointers to be used on 64-bit CPUs for managed runtime applications that do not need the full 64-bit address space. We describe our pointer compression techniques and discuss our experience implementing these for Java applications. In addition, we give performance results with our techniques for both the SPEC JVM98 and SPEC JBB2000 benchmarks. We demonstrate a 12% performance improvement on SPEC JBB2000 and a reduction in the number of garbage collections required for a given heap size.
Synthesis and Biological Activity of Natural Aminocyclopentitol Glycosidase Inhibitors:  Mannostatins, Trehazolin, Allosamidins, and Their Analogues (1999)

International audience
Biochemical map of polypeptides specified by foot-and-mouth disease virus (1984)

Pulse-chase labeling of foot-and-mouth disease virus-infected bovine kidney cells revealed stable and unstable viral-specific polypeptides. To identify precursor-product relationships among these polypeptides, antisera against a number of structural and nonstructural viral-specific polypeptides were used. Cell-free translations programmed with foot-and-mouth disease virion RNA or foot-and-mouth disease virus-infected bovine kidney cell lysates, which were shown to contain almost identical polypeptides, were immunoprecipitated with the various antisera. To further establish identity, some proteins were compared by partial protease digestion. Evidence for a membrane association of the polypeptides coded for by the middle genome region is also presented. A biochemical map of the foot-and-mouth disease virus genome was established from the above information.