gebhart/patrepeval huggingface dataset:
Pilot Interference Cancellation Technology for CDMA Cellular Networks (2005)

This paper considers the link-level and network-level performance of code division multiple access (CDMA) pilot interference cancellation (pilot IC) technology, a low-complexity advanced receiver technology being considered for use in commercial third generation (3G) CDMA cellular systems. The concept behind this technology is to estimate and cancel at the handset receiver the interference effects associated with CDMA downlink pilot signals broadcast from the base stations of the network. The canceling of interference at the receiver improves the signal-to-interference/noise ratio (SINR), which enables increased cell capacity or throughput. In this paper, we derive SINR expressions for evaluating the probability of error performance of both the RAKE and pilot IC handset receivers, under conventional random spreading code assumptions. The approach can easily and accurately model a wide variety of transmitter, channel, and receiver conditions, including the effects of channel estimation. We also utilize radio network simulations to illustrate and quantify the capacity gains available for 3G CDMA networks through the use of pilot IC handsets. Network simulations are also used to examine the reduced level of soft-handoff found to be possible in pilot IC-based networks and the increased flexibility available in setting pilot power levels. We further consider the impact of using stronger pilot signals for improving the demodulation performance of sensitive higher-order modulation constellations that are needed to support spectrally efficient high-rate data services.
Tumour eradication and induction of memory against murine mesothelioma by combined immunotherapy (53.22) (2012)

Abstract Numerous immunotherapy treatments for cancer are undergoing clinical trials or are already approved for use. One particular area of interest is targeting mechanisms of immune tolerance. Using a murine model of mesothelioma, we investigated the roles of regulatory T-cells (Tregs), intra-tumoural transforming growth factor (TGF)-β and the immunosuppressive cytotoxic T lymphocyte-associated (CTLA)-4 molecule in immune tolerance to tumours. It was found that treatments targeting a single immunosuppressive mechanism were not as effective against tumours as targeting multiple mechanisms simultaneously. Combined Treg depletion and intra-tumoural TGF-β neutralisation resulted in the generation of an anti-tumour response however; this treatment regime was limited by the eventual return of the Tregs around 7-10 days following depletion. In this study we report that combining CTLA-4 blockade with our previously published combined Treg depletion/TGF-β neutralisation regime not only permanently cleared established tumours in ~50% of treated mice. Most importantly, it was found that a combined triple treatment of anti-CD25 mAb, anti-CTLA-4 mAb and TGF-β soluble receptor resulted in prolonged depletion of Tregs, long term clearance of tumours and memory against tumour rechallenge. These data suggest that clinical application of immunotherapies against tumours may be improved by targeting multiple immune suppression mechanisms simultaneously.
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber. (2004)

In the present study, a first-generation adenovirus (Ad) vector was modified with the RGD peptide inserted into the fiber. The insertion of an integrin-targeting sequence into the Ad vector notably enhanced the luciferase expression in the Coxsackie virus and Adenovirus Receptor-deficient A2058 and B16BL6 melanoma cells. The results of an in vivo study with tumor-bearing mice also showed that Ad-RGD-Luc had enhanced gene expression in many organs and in the B16BL6 tumor compared to that induced by a conventional Ad vector after intravenous injection.
Wetting of Ga Droplets in SiO2/Si Cavities: Application to Self-Assisted GaAs Nanowire Growth (2022)

In this paper, we compute and compare the surface energy of various Ga liquid droplets wetting a cylindrical cavity in various configurations. While for some of these configurations, the surface energy can be computed explicitly; for others, numerical computation is needed. Motivated by the results obtained for the cylindrical cavities, we explore the case of the more realistic situation, conical cavities. Our results provide a relation between the geometry of the conical cavity and the equilibrium wetting angles of the droplet on the bottom and on the sidewall of the cavity, which insures the dewetting of the lateral surface. This is an important result toward the control of the verticality during nanowire growth by the vapor–liquid–solid method.
High active carrier concentration in n-type, thin film Ge using delta-doping (2012)

We demonstrate CVD in situ doping of Ge by utilizing phosphorus delta-doping for the creation of a high dopant diffusion source. Multiple monolayer delta doping creates source phosphorous concentrations above 1 × 10[superscript 20]cm[superscript −3], and uniform activated dopant concentrations above 4 × 10[superscript 19]cm[superscript −3] in a 600-800nm thick Ge layer after in-diffusion. By controlling dopant out-diffusion, near-complete incorporation of phosphorus diffusion source is shown.
Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT (2019)

DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and mutagenic. Foremost among the mutagenic lesions is <i>O</i><sup>6</sup>-methylguanine (m6G), which base pairs with thymine during replication to cause GC → AT mutations. The <i>gpt</i> delta C57BL/6J mouse strain of Nohmi et al. (<i>Mol. Mutagen</i> <b>1996</b>, <i>28</i>, 465-70) reliably produces mutational spectra of many DNA damaging agents. In this work, mouse embryo fibroblasts (MEFs) were made from <i>gpt</i> delta C57BL/6J mice and evaluated as a screening tool to determine the qualitative and quantitative features of mutagenesis by <i>N</i>-methyl-<i>N</i>-nitrosourea (MNU), a direct-acting DNA alkylator that serves as a model for environmental <i>N</i>-nitrosamines, such as <i>N</i>-nitrosodimethylamine and therapeutic agents such as Temozolomide. The DNA repair protein MGMT (<i>O</i><sup>6</sup>-methylguanine DNA methyltransferase) protects against environmental mutagenesis by DNA methylating agents and, by removing m6G, limits the therapeutic potential of Temozolomide in cancer therapy. The <i>gpt</i> delta MEFs were treated with MNU to establish dose-dependent toxicity. In parallel, MNU mutagenicity was determined in the presence and absence of the MGMT inhibitor AA-CW236 (4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole). With and without the inhibitor, the principal mutagenic event of MNU was GC → AT, but more mutations were observed when the inhibitor was present. Evidence that the mutagenic lesion was m6G was based on mass spectral data collected using <i>O</i><sup>6</sup>-methyl-<i>d</i><sub>3</sub>-guanine as an internal standard; m6G levels were higher in AA-CW236 treated MEFs by an amount proportional to the higher mutation frequency seen in the same cells. This work establishes <i>gpt</i> delta MEFs as a versatile tool for probing mutagenesis by environmental and therapeutic agents and as a cell culture model in which chemical genetics can be used to determine the impact of DNA repair on biological responses to DNA damaging agents.
X Band RF Interface Technology with Both Low Loss Characteristic and Low Thermal Insulating (2018)

We have proposed a new RF interface technology between cold stage and room temperature stage at X band. The RF interface has both low loss characteristic and low thermal insulating. In general, loss characteristic and thermal insulating is relationship of trade off. Conventional cryogenic receiver uses low loss RF coaxial cable and high power cryogenic cooler. High power cryogenic cooler is large volume. Therefore, small cryogenic receiver had been difficult. The dominant cause for thermal insulating is ground metal of RF transmission line. The proposed transmission line for RF interface consists of separated ground metal and floating metal lines for rejection of RF radiation on polyimide substrate. The separated ground metal realizes thermal insulating less than 1/10 that of 3.2 mm semirigid coaxial copper cable. On the other hand, the floating metal lines on both side of signal line realize low loss characteristic. Proposed RF interface was insertion loss of less than 0.2dB at X band and thermal input of about 30 mW. This RF interface technology is impossible to expect of small high-sensitivity cryogenic receiver.
Spray Conditioning for the Preparation of Spray Dried Submicron Particles (2017)

Particle size reduction down to the submicron range (0.1-1 µm) is an effective option to increase the bioavailabilityof low water soluble active pharmaceutical ingredients. According to the Nernst-Brunner equation, the preparation of submicron sized particles increases the specific surface area, thus increases the dissolution rate. Conventional spray drying devices for submicron particles show certain limitations. The main challenge is the preparation of small and uniform droplets during the atomisation step. In this work, fine droplets were generated combining a nozzle with a droplet separator. Therefore, the aerosol is generated with a pneumatic nozzle and is sprayed into a cyclone droplet separator. Depending on the characteristics of the cyclone, droplets larger than the cut-off-size were separated and returned into the liquid feed. The conditioned aerosol at the top of the cyclone separator can then be introduced into the drying chamber. With this concept the usable part is separated, thus no classification process after drying is necessary. The investigations show that the dependencies during atomisation of the droplets size on the liquid-to-gas mass flow ratio µm and the liquid properties (e.g. viscosity) do not apply to the separation step. The conditioned aerosol only depends on the separation characteristics of the cyclone droplet separator. However, the amount of droplets separated is determined by the atomisation step. Hence, the amount of droplets smaller than the cut-off-size can be increased by decreasing the droplet size of the primary aerosol. This is realised by secondary droplet fragmentation. An impact surface causes breakup of the droplets of theprimary aerosol before separation. The investigations show an increased amount of droplets &amp;lt;2µm.DOI: http://dx.doi.org/10.4995/ILASS2017.2017.4701
Upgrade Capacity Scenarios Enabled by Multi-band Optical Systems (2019)

The ITU-G.652D is the most deployed optical fiber worldwide and presents a wide low-loss window with negligible water absorption peak. Multi-band systems exploit this characteristic to increase the transmission capacity. In this work, we show the optical degradation in terms of generalized signal-to-noise ratio, on different bands, resulting from successive channel upgrades until the complete low-loss window is occupied.
Preparation and Characteristics of Carbon Nanotubes Filled with Cobalt (2000)

Carbon nonotubes filled with long continuous cobalt nanorods or nanoparticles were synthesized by a simple catalytic process. Co(CO)3NO was used as the precursor and served as both the source for the carbon nanotubes and for the cobalt, the catalyst. Some nanotubes filled with nanorods have big heads. The Co-filled nanotubes can be separated easily from the products by using a permanent magnet. The average diameter of the multiwalled nanotubes is about 40 nm. The cobalt nanorods are a few micrometers long with a diameter of 20 nm. In addition, some long, ribbonlike structures of flattened nanotubes were also observed in the product mixture. After sonication of the product mixture, a small number of nanotube rings with cobalt nanoparticles were found. X-ray diffraction analysis shows the cobalt nanorods encapsulated in the carbon nanotubes as having an fcc and not the stable hexagonal structure. A growth mechanism for these filled nanotubes is proposed. XPS and Raman spectrum were also employed to analyze the products. The dc magnetic measurements were conducted to test for its magnetic properties.
Two-step capillary force lithography for fabricating biomimetic, superhydrophobic surfaces (2008)

Inhibition effects in UV radiation curing by oxygen were utilized for fabricating monolithic, micro/nanoscale hierarchical polymer structures via two-step UV-assisted capillary force lithography. It was found that the UV exposure time for the partial curing of microstructure was a crucial parameter; a shorter exposure time induced collapse of the underlying microstructure while a longer time gave rise to non-fluidity of the microstructure. The partial curing is attributed to inhibition of UV cross linking by trapped or permeated oxygen within mold cavities. Using this method, various dual-scale hierarchical structures were fabricated with minimum resolution to 50 nm over a large area (5×5 ㎠) in a fast and reproducible manner.
Enhancement of Stochastic Resonance Using Optimization Theory (2006)

The traditional stochastic resonance is realized by adding an optimal amount of noise, while the parameter-tuning stochastic resonance is realized by optimally tuning the system parameters.This paper reveals the possibility to further enhance the stochastic resonance effect by tuning system parameters and adding noise at the same time using optimization theory.The further improvement of the maximal normalized power norm of the bistable double-well dynamic system with white Gaussian noise input can be converted to an optimization problem with constraints on system parameters and noise intensity, which is proven to have one and only one local maximum for the Gaussian-distributed weak input signal.This result is then extended to the arbitrary weak input signal case.For the purpose of practical implementation, a fast-converging optimization algorithm to search the optimal system parameters and noise intensity is also proposed.Finally, computer simulations are performed to verify its validity and demonstrate its potential applications in signal processing.
Lacrimal gland, tear film, and dry eye syndromes : basic science and clinical relevance (1994)

Claes H. Dohlman Conference Address. 1. Understanding Dry Eye Syndrome K. Tsubota. Lacrimal Gland: Cellular And Molecular Biology. 2. GDNF Family Signaling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development J. Rossi, M.S. Airaksinen. 3. The Influence of Aging in the Insulin Signaling System in Rat Exocrine Glands E.M. Rocha, et al. 4. Cloning, Partial Sequencing and Expression of Rabbit Lacrimal Grand beta-Hexosaminidase J.P. Gierow, et al. 5. Differential Expression of Adenylyl Cyclase mRNAs in Lacrimal Glands of NZB/NZW and NOD Pre-Autoimmune Mice M.A. Meneray, T.E. Lallier. 6. M3 Receptor Autoimmunity. Losing Tolerance to a Familair Protein A.K. Mircheff, et al. 15 Additional Chapters. Lacrimal Gland And Ocular Surface: Signal Transduction, Membrane Traffic And Fluid And Protein Secretion. 22. Genetic Separation of the Human Lacritin Gene and Triple A (Allgrove) Syndrome on 12Q13 R. Kumar, et al. 23. Ca2 Signaling in Polarized Exocrine Cells K. Kiselyov, et al. 24. Role of Ca2+ and Protein Kinase C in Cholinergic and alpha1-Adrenergic Agonists and EGF Stimulated Mitogen-Activated Protein Kinase Activity in Lacrimal Gland J.D. Rios, et al. 25. A Model of Fluid Secretion By the Acinar Cells of the Mouse Lacimal Gland B. Walcott, et al. 26. Cytoskeletal Participation in Stimulated Secretion and Compensatory Apical Plasma Membrane Retrieval in Lacrimal Gland Acinar Cells S.R. da Costa, et al. 10 Additional Chapters. Mucins: Origin, Properties, RegulationAnd Function. 37. Mechanism by Which Bacterial Flagellin Stimulates Host Mucin Production N. McNamara, C. Basbaum. 38. Mucins and Ocular Surface Disease S.H. Hibino, et al. 39. Functional Processing of Ocular Mucins M. Berry, et al. 40. ERBB2 and its Ligand MUC4 (Sialomucin Complex) in Rat Lacrimal Gland K.L. Carraway, et al. 41. Role of Mitogen-Activated Protein Kinase in Cholinergic Stimulation of Conjunctival Goblet Cell Secretion D.A. Dartt, et al. 42. Isolation and Characterization of Human Goblet Cells in vitro: Regulation of Proliferation and Activation of Mitogen-Activated Protein Kinase by EGF and Carbachol M.A. Shatos, et al. 43. Human Conjunctival Epithelium in Culture: A Tool to Assay New Therapeutic Strategies for Dry Eye Y. Diebold, et al. 10 Additional Chapters. Meibomian Gland Art Tear Film Lipids: Structure, Function And Control. 54. Meibomian Gland and Tear Film Lipids: Structure, Function and Control J.P. McCulley, W. Shine. 55. Androgen Regulation of Lipogenesis J.V. Swinnen, et al. 56. Sex steroids, the Meibomian Gland and Evaporative Dry Eye D.A. Sullivan, et al. 57. The Lipid Layer and Stability of Tears in Human Newborns S.J. Isenberg, et al. 58. Interface Properties of Simplified Tear-Like Fluids in Relation of Lipid and Aqueous Layers Composition F. Miano, et al. 15 Additional Chapters. Ocular Surface Homeostasis I: Tear Film Proteins & Stability. 74. The Tear Film and Defense Against Infection S.M.J. Fleiszig, et al. 75. Nerve Growth Factor: An Impor
The introduction of the fungal d-galacturonate pathway enables the consumption of d-galacturonic acid by Saccharomyces cerevisiae (2016)

This work is the first demonstration of the expression of a functional heterologous pathway for D-galacturonic acid catabolism in Saccharomyces cerevisiae. It is a preliminary step for engineering a yeast strain for the fermentation of pectin-rich substrates to ethanol.
The state of quantum computing applications in health and medicine (2023)

Abstract Quantum computing hardware and software have made enormous strides over the last years 1 . Questions around quantum computing’s impact on research and society have changed from “if” to “when/how”. The 2020s have been described as the “quantum decade”, and the first production solutions that drive scientific and business value are expected to become available over the next years. Medicine, including fields in healthcare and life sciences, has seen a flurry of quantum-related activities and experiments in the last few years (although medicine and quantum theory have arguably been entangled ever since Schrödinger’s cat 2 ). The initial focus was on biochemical and computational biology problems 3 , 4 , 5 , 6 , 7 , 8 ; recently, however, clinical and medical quantum solutions have drawn increasing interest. The rapid emergence of quantum computing in health and medicine necessitates a mapping of the landscape. In this review, clinical and medical proof-of-concept quantum computing applications are outlined and put into perspective. These consist of over 40 experimental and theoretical studies from the last few years. The use case areas span genomics, clinical research and discovery, diagnostics, and treatments and interventions. Quantum machine learning (QML) in particular has rapidly evolved and shown to be competitive with classical benchmarks in recent medical research. Near-term QML algorithms, for instance, quantum support vector classifiers and quantum neural networks, have been trained with diverse clinical and real-world data sets. This includes studies in generating new molecular entities as drug candidates, diagnosing based on medical image classification, predicting patient persistence, forecasting treatment effectiveness, and tailoring radiotherapy. The use cases and the applied algorithms are summarized. In addition, this review provides an outlook on medicine in the quantum era. There has been much discussion about healthcare’s journey towards precision medicine and the quadruple aim (better health, lower costs, enhanced patient experiences, and improved healthcare practitioner work lives) 9 . While a range of technical and ethical challenges remain, quantum computing is poised to become a key enabler for advancing towards the holy grail: keeping people healthy through proactive medical care and guidance at the level of an individual.
Coordinate Downregulation of a Novel Imprinted Transcript ITUP1 with PEG3 in Glioma Cell Lines (2004)

The human paternally expressed gene 3 (PEG3) on chromosome 19q13.4 is one of the candidate tumor suppressor genes for glioma. We have previously reported that the epigenetic silencing of PEG3 expression in glioma cell lines is dependent on aberrant DNA methylation of an exonic CpG island. Here, we have identified three expressed sequence tags (ESTs), H80201, H78825 and AW197312, that exhibit paternal allele-specific expression, using human monochromosomal hybrids containing the paternal or maternal origin of PEG3 locus. The EST H80201 was shown to be expressed only from the paternal allele in normal human lymphoblasts by utilizing a single nucleotide polymorphism (SNP). Monoallelic expression of EST H80201 was also detected in non-tumor adult human brain tissues of gliomas. These ESTs were located directly adjacent to PEG3 in a head-to-head orientation. We have named this new transcript, imprinted transcript 1, which is located upstream but oppositely oriented to PEG3 (ITUP1). The ITUP1 showed a similar expression profile with PEG3 in glioma cell lines. Bisulfite genomic sequencing and reverse transcription (RT)-PCR analysis indicated that hypermethylation of the promoter region correlated with the absence of these transcripts. This suggests that ITUP1 and PEG3 are coordinately regulated, and that downregulation of the both genes may be important in the development of glioma.
RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma (2009)

The interaction of multiple myeloma (MM) cells with the bone marrow (BM) milieu plays a crucial role in MM pathogenesis. Stromal cell-derived factor-1 (SDF1) regulates homing of MM cells to the BM. In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis of MM. We found that both RhoA and Rac1 play key roles in SDF1-induced adhesion of MM cells to BM stromal cells, whereas RhoA was involved in chemotaxis and motility. Furthermore, both ROCK and Rac1 inhibitors reduced SDF1-induced polymerization of actin and activation of LIMK, SRC, FAK, and cofilin. Moreover, RhoA and Rac1 reduced homing of MM cells to BM niches. In conclusion, we characterized the role of RhoA and Rac1 GTPases in SDF1-induced adhesion, chemotaxis, and homing of MM cells to the BM, providing the framework for targeting RhoA and Rac1 GTPases as novel MM therapy.