gebhart/patrepeval huggingface dataset:
Experimental Evaluation of Human Motion Prediction: Toward Safe and Efficient Human Robot Collaboration (2020)

Human motion prediction is non-trivial in modern industrial settings. Accurate prediction of human motion can not only improve efficiency in human robot collaboration, but also enhance human safety in close proximity to robots. Among existing prediction models, the parameterization and identification methods of those models vary. It remains unclear what is the necessary parameterization of a prediction model, whether online adaptation of the model is necessary, and whether prediction can help improve safety and efficiency during human robot collaboration. These problems result from the difficulty to quantitatively evaluate various prediction models in a closed-loop fashion in real human-robot interaction settings. This paper develops a method to evaluate the closed-loop performance of different prediction models. In particular, we compare models with different parameterizations and models with or without online parameter adaptation. Extensive experiments were conducted on a human robot collaboration platform. The experimental results demonstrated that human motion prediction significantly enhanced the collaboration efficiency and human safety. Adaptable prediction models that were parameterized by neural networks achieved the best performance.
Heartbeat Classification in Wearables Using Multi-layer Perceptron and\n Time-Frequency Joint Distribution of ECG (2019)

Heartbeat classification using electrocardiogram (ECG) data is a vital\nassistive technology for wearable health solutions. We propose heartbeat\nfeature classification based on a novel sparse representation using\ntime-frequency joint distribution of ECG. Fundamental to this is a multi-layer\nperceptron, which incorporates these signatures to detect cardiac arrhythmia.\nThis approach is validated with ECG data from MIT-BIH arrhythmia database.\nResults show that our approach has an average 95.7% accuracy, an improvement of\n22% over state-of-the-art approaches. Additionally, ECG sparse distributed\nrepresentations generates only 3.7% false negatives, reduction of 89% with\nrespect to existing ECG signal classification techniques.\n
Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models (2017)

Abstract The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that in preclinical models, malignant rhabdoid tumors, which are deficient in the SWI/SNF core component INI1 (SMARCB1), are selectively killed by inhibitors of the H3K27 histone methyltransferase EZH2. Given the demonstrated antagonistic activities of the SWI/SNF complex and the EZH2-containing PRC2 complex, we investigated whether additional cancers with SWI/SNF mutations are sensitive to selective EZH2 inhibition. It has been recently reported that ovarian cancers with dual loss of the redundant SWI/SNF components SMARCA4 and SMARCA2 are characteristic of a rare rhabdoid-like subtype known as small-cell carcinoma of the ovary hypercalcemic type (SCCOHT). Here, we provide evidence that a subset of commonly used ovarian carcinoma cell lines were misdiagnosed and instead were derived from a SCCOHT tumor. We also demonstrate that tazemetostat, a potent and selective EZH2 inhibitor currently in phase II clinical trials, induces potent antiproliferative and antitumor effects in SCCOHT cell lines and xenografts deficient in both SMARCA2 and SMARCA4. These results exemplify an additional class of rhabdoid-like tumors that are dependent on EZH2 activity for survival. Mol Cancer Ther; 16(5); 850–60. ©2017 AACR.
A Common Surface Antigen in Influenza Viruses from Human and Avian Sources (1968)

Summary Serological cross-reactions were detected between four avian influenza viruses and a human A 2/57 virus and between an avian (TURKEY/CANADA/63) and an equine (EQUI 2/MIAMI/63) strain. The reactions were detected by strain-specific complement fixation tests and neuraminidase inhibition but not by haemagglutination-inhibition. Specific antiserum to the neuraminidase of an A 2/57 virus also reacted with the four avian viruses showing that it was the neuraminidase antigen on the avian and human A 2 virus that were antigenically closely related. The possibility that these viruses may have arisen by recombination between human and avian influenza viruses in nature is discussed.
CLEAVAGE AT SINGLE BASIC RESIDUES AND ENHANCED PROCESSING IN THE PRESENCE OF CARBOXYPEPTIDASE ACTIVITY (1998)

Endoproteolytic processing of the 26-kDa protein precursor prodynorphin (proDyn) at paired and single basic residues is most likely carried out by the proprotein convertases (PCs); however, the role of PCs at single basic residues is unclear. In previous studies we showed that limited proDyn processing by PC1/PC3 at both paired and single basic residues resulted in the formation of 8- and 10-kDa intermediates. Because PC2 is colocalized with proDyn, we examined the potential role of this convertase in cleaving proDyn. PC2 cleaved proDyn to produce dynorphin (Dyn) A 1‐17, Dyn B 1‐13, and a-neo-endorphin, without a previous requirement for PC1/PC3. PC2 also cleaved at single basic residues, resulting in the formation of the C-peptide and Dyn A 1‐ 8. Only PC2, but not furin or PC1/PC3, could cleave the Arg-Pro bond to yield Dyn 1‐ 8. Structure-activity studies with Dyn A 1‐17 showed that a P4 Arg residue is important for single basic cleavage by PC2 and that the P1* Pro residue impedes processing. Conversion of Dyn A 1‐17 or Dyn B 1‐13 into leucine-enkephalin (Leu-Enk) by PC2 was never observed; however, Dyn AB 1‐32 cleavage yielded small amounts of Leu-Enk, suggesting that Leu-Enk can be generated from the proDyn precursor only through a specific pathway. Finally, PC2 cleavages at single and paired basic residues were enhanced when carried out in the presence of carboxypeptidase (CP) E. Enhancement was blocked by GEMSA, a specific inhibitor of CPE activity, and could be duplicated by other carboxypeptidases, including CPD, CPB, or CPM. Our data suggest that carboxypeptidase activity enhances PC2 processing by the elimination of product inhibition caused by basic residue-extended peptides.
Proteins in Different Synechocystis Compartments Have Distinguishing N-Terminal Features:  A Combined Proteomics and Multivariate Sequence Analysis (2007)

Cyanobacteria have a cell envelope consisting of a plasma membrane, a periplasmic space with a peptidoglycan layer, and an outer membrane. A third, separate membrane system, the intracellular thylakoid membranes, is the site for both photosynthesis and respiration. All membranes and luminal spaces have unique protein compositions, which impose an intriguing mechanism for protein sorting of extracytoplasmic proteins due to single sets of translocation protein genes. It is shown here by multivariate sequence analyses of many experimentally identified proteins in Synechocystis, that proteins routed for the different extracytosolic compartments have correspondingly different physicochemical properties in their signal peptide and mature N-terminal segments. The full-length mature sequences contain less significant information. From these multivariate, N-terminal property-profile models for proteins with single experimental localization, proteins with ambiguous localization could, to a large extent, be predicted to a defined compartment. The sequence properties involve amino acids varying especially in volume and polarizability and at certain positions in the sequence segments, in a manner typical for the various compartment classes. Potential means of the cell to recognize the property features are discussed, involving the translocation channels and two Type I signal peptidases with different cellular localization, and charge features at their membrane interfaces.
Evidence against a Nucleophilic Mechanism for Monoamine Oxidase-Catalyzed Amine Oxidation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence against a Nucleophilic Mechanism for Monoamine Oxidase-Catalyzed Amine OxidationRichard B. Silverman and Xingliang LuCite this: J. Am. Chem. Soc. 1994, 116, 9, 4129–4130Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ja00088a079https://doi.org/10.1021/ja00088a079research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of Women with Postmenopausal Uterine Bleeding: Clinical Practice Recommendations (2013)

Postmenopausal uterine bleeding is defined as uterine bleeding after permanent cessation of menstruation resulting from loss of ovarian follicular activity. Bleeding can be spontaneous or related to ovarian hormone replacement therapy or to use of selective estrogen receptor modulators (eg, tamoxifen adjuvant therapy for breast carcinoma). Because anovulatory "cycles" with episodes of multimonth amenorrhea frequently precede menopause, no consensus exists regarding the appropriate interval of amenorrhea before an episode of bleeding that allows for the definition of postmenopausal bleeding. The clinician faces the possibility that an underlying malignancy exists, knowing that most often the bleeding comes from a benign source. Formerly, the gold-standard clinical investigation of postmenopausal uterine bleeding was institution-based dilation and curettage, but there now exist office-based methods for the evaluation of women with this complaint. Strategies designed to implement these diagnostic methods must be applied in a balanced way considering the resource utilization issues of overinvestigation and the risk of missing a malignancy with underinvestigation. Consequently, guidelines and recommendations were developed to consider these issues and the diverse spectrum of practitioners who evaluate women with postmenopausal bleeding. The guideline development group determined that, for initial management of spontaneous postmenopausal bleeding, primary assessment may be with either endometrial sampling or transvaginal ultrasonography, allowing patients with an endometrial echo complex thickness of 4 mm or less to be managed expectantly. Guidelines are also provided for patients receiving selective estrogen receptor modulators or hormone replacement therapy, and for an endometrial echo complex with findings consistent with fluid in the endometrial cavity.�
A Connectomic Atlas of the Human Cerebrum—Chapter 4: The Medial Frontal Lobe, Anterior Cingulate Gyrus, and Orbitofrontal Cortex (2018)

In this supplement, we build on work previously published under the Human Connectome Project. Specifically, we show a comprehensive anatomic atlas of the human cerebrum demonstrating all 180 distinct regions comprising the cerebral cortex. The location, functional connectivity, and structural connectivity of these regions are outlined, and where possible a discussion is included of the functional significance of these areas. In part 4, we specifically address regions relevant to the medial frontal lobe, anterior cingulate gyrus, and orbitofrontal cortex.
ChemInform Abstract: Sulfones as Peptide Bond Isosteres. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enabling Active Data Archival over Cloud (2012)

The need to analyze huge amount of data for various business intelligence applications is well known. However, the rate at which enterprise data is generated now demands periodic migration of older data from the operational data warehouse to magnetic tapes. In this paper, we propose an "Active data archival service" in which the data is seamlessly archived on the cloud while ensuring that the archived data can be queried without any perceptible change to the end-user. This takes the burden of maintaining the archive off the user and shifts it to the archival service. We discuss the architecture of the service, challenges arising therein due to the federation of data brought on by the archival and how we handle these issues. Specifically, we investigate how the relational data needs to be transformed so that storing and retrieving the data from the cloud is efficient and seamless to the end user. We present our insights through an experimental study using TPC-DS benchmark.
The role of MicroRNAs in human cancer (2016)

MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of gene expression. Compelling evidences have demonstrated that miRNA expression is dysregulated in human cancer through various mechanisms, including amplification or deletion of miRNA genes, abnormal transcriptional control of miRNAs, dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. MiRNAs may function as either oncogenes or tumor suppressors under certain conditions. The dysregulated miRNAs have been shown to affect the hallmarks of cancer, including sustaining proliferative signaling, evading growth suppressors, resisting cell death, activating invasion and metastasis, and inducing angiogenesis. An increasing number of studies have identified miRNAs as potential biomarkers for human cancer diagnosis, prognosis and therapeutic targets or tools, which needs further investigation and validation. In this review, we focus on how miRNAs regulate the development of human tumors by acting as tumor suppressors or oncogenes.
Eventual Chemical Transformation of Metals and Chalcogens into Metal Chalcogenide Nanoplates through a Surface Nucleation-Detachment-Reorganization Mechanism (2017)

Many studies have reported the synthesis of two-dimensional (2D) nanoplates and nanosheets of the layer-structured metal chalcogenides but also have reported various structures far from the 2D shape. In multicomponent compounds, the elemental concentrations keep changing during the reaction; hence, the reactions are considered to be nonstoichiometric from the nucleation and may include continuous changes in the structure and composition. The different shapes of the metal chalcogenides with the layered structure are attributed to the nonstoichiometric reactions. However, it has not been studied if such nonstoichiometric reactions eventually produce 2D nanoplates, and the mechanism involved in the transformation has not been understood. This study investigates a two-step chemical reaction as an extreme nonstoichiometric nucleation and growth. It reveals that the layer-structured metal chalcogenides (M2X3, M = Sb and Bi, X = Se and Te) with the R3̅m space group can be obtained by transforming premade pure chalcogen (Se, Te) thick nanorods or metal microparticles (Bi). By coupling our first-principles calculations with a shape-prediction thermodynamic model, we have also examined and rationalized the shape/aspect ratio of the M2X3 nanocrystals under different experimental growth conditions. The tendency of anisotropic growth to form the 2D shapes during the transformations are discussed on the basis of experimental results and theoretical calculations.
Gain Spectroscopy on InGaN/GaN Quantum Well Laser Diodes (1998)

In spite of advances that have led to the demonstration of a 1000 hour cw blue InGaN QW diode laser, as well of the demonstration of cw operation on a SiC substrate [1], major unanswered questions exist about the physics of optical gain in this disordered QW system, given the large departure of InGaN from a random alloy in terms of microscopic scale In-compositional fluctuations. We have reported on gain spectra obtained on InGaN/GaN pn-junction heterostructures [2]. Useful information has been acquired but spectroscopic details were incomplete.
Digital Signal Recovery With Transmitter Nonlinear State Tracking for Satellite Communications (2022)

This brief proposes a digital signal recovery (DSR) method to compensate the nonlinear distortion introduced by power amplifiers (PAs) under dynamic nonlinear operating states. Unlike conventional PA linearization methods that extract the nonlinearity based on the baseband I/Q PA input and output signal samples, the proposed method attempts to derive the memory polynomial (MP) model parameters based on PA operating states using a deep neural network (DNN). This method allows the receiver to achieve DSR by tracking the operating states of the PA effectively with a few telemetry data. Validation results from simulations and experiments based on a GaN PA operating at 3.5 GHz reveal that the proposed method can maintain satisfactory DSR performance in terms of adjacent channel power ratio (ACPR) and error vector magnitude (EVM) while the transmitter PA is operating with fluctuating average input/output power, supply voltage, and bias voltage. The training data size and time are further reduced by using a transfer learning (TL) approach.
High-Tc (95 K) As-Grown Superconducting Bi-Sr-Ca-Cu-O Thin Films (1990)

As-grown superconducting thin films of the Bi-Sr-Ca-Cu-O system were prepared on MgO(100) substrates by a three-target rf magnetron sputtering system with a regulated shuttering technique. Using this system, Bi-Sr-Ca-Cu-O superconducting high- T c -phase films (700 Å) with a thin Bi-Sr-Cu-O semiconductor-like-phase buffer layer (70 Å) were deposited on MgO (100) substrates under rigorous control of the film composition at 760°C. The superconducting transition temperature of the as-grown film was 115 K ( T c on ) and 95 K ( T c zero ). The surface of this film was very smooth and uniform.
Motion Plane Estimation for Real-Time Hand Motion Recognition (2009)

손동작을 인식하는 연구가 오랫동안 이뤄져 왔지만 대개의 시스템들이 값비싼 깊이 카메라를 사용하거나 여러 개의 카메라를 사용해 분석하는 등 그 비용이 크며 작동이 가능한 작업 공간이 지극히 제한적이었다. 본 논문에서는 가전제품을 원격 제어하기 위한 목적으로 두 개의 회전 모터를 사용해 작업 공간을 확대하고 저렴한 일반 카메라를 사용해서 효율적으로 손동작을 인식하기 위한 시스템을 제안한다. 이 시스템은 입력된 카메라의 자세 정보와 이미지상의 2차원적 손가락 위치 정보를 이용하여 3차원 궤적을 추정하고 이를 동작 평면으로 투영시켜 의미 있는 선형 동작 패턴으로 복원한다. 또한 본 논문에서는 개발된 시스템을 테스트하여 주어진 목적에 맞는 정확도를 가지는 작업 영역을 정의한다. In this thesis, we develop a vision based hand motion recognition system using a camera with two rotational motors. Existing systems were implemented using a range camera or multiple cameras and have a limited working area. In contrast, we use an uncalibrated camera and get more wide working area by pan-tilt motion. Given an image sequence provided by the pan-tilt camera, color and pattern information are integrated into a tracking system in order to find the 2D position and direction of the hand. With these pose information, we estimate 3D motion plane on which the gesture motion trajectory from approximately forms. The 3D trajectory of the moving finger tip is projected into the motion plane, so that the resolving power of the linear gesture patterns is enhanced. We have tested the proposed approach in terms of the accuracy of trace angle and the dimension of the working volume.
Introduction (2020)

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book aims to take each realm or notion of ecology, as it relates to spatial design seriously and discover synergies between them in ways that only professionals and designers of the built environment can. Part 1 of the book investigates how architectural, urban, and landscape architectural design and practices can both integrate with and support the regeneration of biological ecologies in various ways. Part 2 focuses on spaces external to or separate from buildings, across cities and geographies, and focuses on the documentation of the social ecologies of urban and landscape space. While there is recognition of the need for changing built environment design and building practices, the interconnected character of practices and the living and built environments we practice into frustrates change. Part 3 investigates these issues and questions that emerge from them.
Wide temperature (25°C-85°C), coolerless operation of 100 Gb/s DWDM transmitter photonic integrated circuit (2005)

A 10-channel dense wavelength division multiplexed photonic integrated circuit is demonstrated that transmits data at 10 Gbit/s per channel for an aggregate data transmission rate of 100 Gbit/s, operating without temperature stabilization between 25°C and 85°C. (2 pages)