gebhart/patrepeval huggingface dataset:
Austenite Reversion Behavior of Maraging Steel Additive-manufactured by Laser Powder Bed Fusion (2023)

This study was set to fundamentally investigate the characteristics of austenite reversion occurring in maraging steels additive-manufactured by laser powder bed fusion (L-PBF). The maraging steel samples manufactured under different L-PBF process conditions (laser power P and scan speed v) were subjected to heat treatments at 550 oC for various durations, compared with the results of the austenitized and water-quenched sample with fully martensite structure. The L-PBF manufactured samples exhibited the martensite structure (including localized austenite (γ) phases) containing submicron-sized cellular structures. Enriched alloy elements were detected along the cell boundaries, whereas such cellar structure was not found in the water-quenched sample. The localized alloy elements can be rationalized by the continuous variations in the γ-phase composition in solidification during the L-PBF process. The precipitation of nanoscale intermetallic phases and the following austenitic reversion occurred in all of the experimental samples. The L-PBF manufactured samples exhibited faster kinetics of the precipitation and austenite reversion than the water-quenched sample at elevated temperatures. The kinetics changed depending on the L-PBF process condition. The enriched Ni element (for stabilizing γ phase) localized at cell boundaries would play a role in the nucleation site for the formation of γ phase at 550 oC, resulting in enhanced austenite reversion in the L-PBF manufactured samples. The variation in the reaction kinetics depending on the L-PBF condition would be due to the varied thermal profiles of the manufactured samples by consecutive scanning laser irradiation operated under different P and v values.
Supplementary Figures 1-10 from Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression (2023)

&lt;p&gt;Supplementary Figures 1-10 and corresponding legends&lt;/p&gt;
Single-cell measurement of plasmid copy number and promoter activity (2021)

Accurate measurements of promoter activities are crucial for predictably building genetic systems. Here we report a method to simultaneously count plasmid DNA, RNA transcripts, and protein expression in single living bacteria. From these data, the activity of a promoter in units of RNAP/s can be inferred. This work facilitates the reporting of promoters in absolute units, the variability in their activity across a population, and their quantitative toll on cellular resources, all of which provide critical insights for cellular engineering.
Supplemental Figure S3 from <sup>18</sup>F-FAZA PET Imaging Response Tracks the Reoxygenation of Tumors in Mice upon Treatment with the Mitochondrial Complex I Inhibitor BAY 87-2243 (2023)

&lt;p&gt;Supplemental Figure S3. Graph derived from the scientific literature (24) that shows a linear correlation between 18F-FPP(RGD)2 uptake and tumor volume in HCT116 human colon cancer xenografts.&lt;/p&gt;
Video coding using streamed 3D representation (2002)

We present a global scheme for encoding/decoding natural video sequences with partial 3D models. This technique is based on a robust estimation of a constrained dense field and on the estimation of projection matrices for reference images. Then a sequential encoding of the sequence is performed in order to produce streamed 3D models. The paper presents the global scheme and focuses on the most original steps of the encoding method. Some results on real video sequences are given to validate this approach.
Optimization of the synthesis of poly(octadecyl acrylate) by atom transfer radical polymerization and the preparation of all comblike amphiphilic diblock copolymers (2005)

Abstract The atom transfer radical polymerization of octadecyl acrylate (ODA) has been investigated and optimized to produce polymers with predetermined molecular weights and narrow polydispersities (&lt;1.2). The poor solubility of the catalytic system formed with conventional ligands such as the N‐( n ‐propyl)‐2‐pyridylmethanimine and 2,2′‐bipyridine with Cu(I)Br in nonpolar reaction conditions gave poor control over molecular weight characteristics in ODA polymerizations. The use of N‐( n ‐octyl)‐2‐pyridylmethanimine in combination with Cu(I)Br yielded a more soluble catalyst that improved control over the polymerization. The products from the polymerizations were further improved when an initiator, octadecyl 2‐bromo‐2‐methyl‐propanoate, similar in structure to the monomer, was used. Together, these modifications produced polymerizations that showed true controlled character as well as products with predetermined molecular weights and narrow polydispersities. Diblock copolymers of PODA were prepared with methyl methacrylate (MMA) and olig(oethylene glycol) methyl ether methacrylate (OEGMA). The PODA‐ block ‐POEGMA copolymers are the first examples of all comblike amphiphilic block copolymers. One of PODA‐ block ‐POEGMA copolymer samples has been shown to self‐assemble as micelles in a dilute aqueous solution. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1129–1143, 2005
Nanotopography Directs Fate of Human Embryonic Stem Cells (2012)

Human embryonic stem cells (hESCs) have remarkable potentials for breakthroughs in future cell-based therapeutics owing to their self-renewal capability and pluripotency [1–2]. However, their intrinsic mechanosensitivity to biophysical signals from the local cellular microenvironment is not well characterized [3–4]. In this work, we introduced a simple, yet precise, microfabrication strategy for accurate control and patterning of local nanoroughness on glass surfaces using photolithography and reactive ion etching (RIE). Our results demonstrated that nanoscale topological features could provide a potent regulatory signal over a diverse array of hESC behaviors, including their morphology, adhesion, proliferation and clonal expansion, and differentiation.
Density functional theory, molecular docking and in vivo muscle relaxant, sedative, and analgesic studies of indanone derivatives isolated from Heterophragma adenophyllum (2020)

<i>Heterophragma adenophyllum</i> (HA) is an important medicinal plant which is used in traditional medicine for the treatment of muscular tension and pain. Herein, we report the isolation of methyl,1,2-dihydroxy-2-(3-methylbut-2-en-1-yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxylate (<b>1</b>), from the roots of <i>H. adenophyllum.</i> The isolated compound <b>1</b> was evaluated for <i>in vivo</i> muscle relaxant, sedative, and analgesic potential in Swiss albino mice. Results revealed that the isolated compound <b>1</b> exhibited a dose- and time-dependent muscle coordination (51%) and a significant (<i>p</i> < 01) sedative effect. It also showed a considerable (<i>p</i> < 0.5) analgesia after 30 min of post treatment and was maintained for up-to 120 min of experimental duration. In acute toxicity studies, no mortality was observed which indicates a preliminary safety of compound <b>1</b>. Furthermore, the experimental results were compared with the theoretical studies by using density functional theory (DFT). The stability of the compound as well as the flow of electrons was determined by the calculated Frontier orbital analysis. The calculated stretching frequencies, <sup>1</sup>H-NMR/<sup>13</sup>C-NMR chemical shift values and UV-visible spectra were found to be in agreement with experimental values. The results obtained from molecular docking studies were used to explore the mechanism of analgesic and muscle relaxant activity.Communicated by Ramaswamy H. Sarma.
Nano bio optically tunable composite nanocrystalline cellulose films (2014)

We utilize nanocellulose and semiconductor nanocrystals to reinforce and functionalize a biodegradable transparent film to create a transparent, strong and optically tunable plastic film.
A reference dataset of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree (2016)

Abstract Improvement of variant calling in next-generation sequence data requires a comprehensive, genome-wide catalogue of high-confidence variants called in a set of genomes for use as a benchmark. We generated deep, whole-genome sequence data of seventeen individuals in a three-generation pedigree and called variants in each genome using a range of currently available algorithms. We used haplotype transmission information to create a phased “platinum” variant catalogue of 4.7 million single nucleotide variants (SNVs) plus 0.7 million small (1-50bp) insertions and deletions (indels) that are consistent with the pattern of inheritance in the parents and eleven children of this pedigree. Platinum genotypes are highly concordant with the current catalogue of the National Institute of Standards and Technology for both SNVs (&gt;99.99%) and indels (99.92%), and add a validated truth catalogue that has 26% more SNVs and 45% more indels. Analysis of 334,652 SNVs that were consistent between informatics pipelines yet inconsistent with haplotype transmission (“non-platinum”) revealed that the majority of these variants are de novo and cell-line mutations or reside within previously unidentified duplications and deletions. The reference materials from this study are a resource for objective assessment of the accuracy of variant calls throughout genomes.
IC–P–013: Greater frontal than cingulate magnetic resonance spectroscopy abnormalities in early Alzheimer disease (2006)

Recently there has been a great emphasis put on finding early imaging markers for Alzheimer Disease (AD). In previous imaging studies, abnormal magnetic resonance spectroscopic signals have been found to be limited to the posterior cingulate regions (Kantarci et al, 2000). These studies did not examine other cortical areas. In early AD, executive function has been shown to be deteriorated when compared to normal age matched subjects. We hypothesized that frontal metabolic abnormalities demonstrated by magnetic resonance spectroscopy (MRS) might actually exceed those demonstrated for posterior cingulated cortex. MRS was performed in the left Brodman area (Ba) 44 (inferior frontal gyrus), left Ba 37 (posterior temporal), and left precuneus (this included the mid posterior cingulate gyrus and precuneus areas) in 10 normal elderly controls (NEC) (mean age = 77.9, 4M : 6F, mean MMSE = 27.56) and 6 mild AD patients (mean age = 81.5, 5M : 1F, mean MMSE = 24.00). The N–acetylaspartate and N–acetylaspartylglutamate (NAA+NAAG) / Creatine (Cr) ratios were calculated for these three areas. There was no significant difference found in the Ba 37 region between normals and AD subjects. The precuneus area had minimal significance (p<0.061). The Ba 44 region showed the most significant (p<0.01) difference between AD patients and NEC subjects. MRS performed in the frontal area might demonstrate earlier changes in mild AD patients and may prove to be useful in prognostication. Frontal cortex MRS should be assessed in pre–dementia state such as Mild Cognitive Impairment (MCI).
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases (2008)

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium channels. Some BTB-domain-containing proteins have been shown recently to participate as substrate-specific adaptors in multimeric cullin E3 ligase reactions by recruiting proteins for ubiquitination and subsequent degradation by the proteasome. Twenty-two KCTD proteins have been found in the human genome, but their functions are largely unknown. In this study, we have characterized KCTD5, a new KCTD protein found in the cytosol of cultured cell lines. The expression of KCTD5 was upregulated post-transcriptionally in peripheral blood lymphocytes stimulated through the T-cell receptor. KCTD5 interacted specifically with cullin3, bound ubiquitinated proteins, and formed oligomers through its BTB domain. Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. These findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases.
[Reoperation in failure of surgical treatment of sciatica]. (1991)

39 patients have been reoperated on for failed lumbar discs. In this series enhanced MRI, enhanced CT scan and disco-CT have been used. These modern imaging means allowed a better assessment for the causes of failure; thus, only in 4 patients was a pure periradicular fibrosis disclosed. The results of reoperations are significantly better than those of a previous series of the same institution, where these imaging devices could not been used. 76% of the patients benefited from reoperation.
AWD: Best Paper Competition (AWD) Enabling Next Generation Video Applications on Consumer Integrated and Discrete Client GPUs (2021)

This "success story" panel illustrates how next generation video applications are enabled on PCs today using consumer integrated and discrete GPUs launched in 2020. Intel's XeLP graphics technology with dedicated media hardware powers the integrated graphics in Intel's latest client processor, Tiger Lake, and Intel's first entry-level mainstream discrete graphics card, DG1. XeLP graphics in Tiger Lake and DG1 has democratized access to high performance implementations of the latest emerging video codec standards. Three topics will be covered: (i) 8K HEVC/AV1 Playback with Content Adaptive Power Optimization; (ii) Ludicrous Speed HEVC Encoding with Integrated + Discrete GPU; and (iii) MPEG Immersive Video (MIV) Playback on DG1.
Noninvasive quantification of fibrosis in skeletal and cardiac muscle in mdx mice using EP3533 enhanced magnetic resonance imaging (2018)

This study provides evidence for the suitability of EP3533 in the quantification of muscular fibrosis in mdx mice and demonstrated that EP3533-derived measurements correlated strongly to ex vivo fibrosis measurement.
Multi-wavelength source at ITU-T grid based on ultra-flattened dispersion photonic crystal fibers (2008)

We report on the development of a multi-wavelength source locked to the ITU-T grid at 100 GHz spacing and based on ultra-flattened dispersion photonic crystal fibers. The ITU-T grid frequencies are generated by taking advantage of multiple four-wave mixing processes. We experimentally obtained 250 products spanning over 200nm by launching 03 strong pump signals. Simulations based on Split-Step Fourier Method have been carried out in order to investigate and improve the performance of this nonlinear optical device.
Use of probiotics, prebiotics, and synbiotics in non‐alcoholic fatty liver disease: A systematic review and meta‐analysis (2023)

Microbiome-targeted therapies were associated with significant improvements in liver-related outcomes in NAFLD patients. Nevertheless, limitations in existing literature like heterogeneity in probiotic strains, dosage, and formulation undermine our findings. This study was registered with PROSPERO (CRD42022354562) and supported by the Nanyang Technological University Start-up Grant and Wang Lee Wah Memorial Fund.
A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation (2019)

The establishment of nitrogen-fixing root nodules in legume-rhizobia symbiosis requires an intricate communication between the host plant and its symbiont. We are, however, limited in our understanding of the symbiosis signaling process. In particular, how membrane-localized receptors of legumes activate signal transduction following perception of rhizobial signaling molecules has mostly remained elusive. To address this, we performed a coimmunoprecipitation-based proteomics screen to identify proteins associated with Nod factor receptor 5 (NFR5) in <i>Lotus japonicus.</i> Out of 51 NFR5-associated proteins, we focused on a receptor-like cytoplasmic kinase (RLCK), which we named NFR5-interacting cytoplasmic kinase 4 (NiCK4). NiCK4 associates with heterologously expressed NFR5 in <i>Nicotiana benthamiana</i>, and directly binds and phosphorylates the cytoplasmic domains of NFR5 and NFR1 in vitro. At the cellular level, <i>Nick4</i> is coexpressed with <i>Nfr5</i> in root hairs and nodule cells, and the NiCK4 protein relocates to the nucleus in an NFR5/NFR1-dependent manner upon Nod factor treatment. Phenotyping of retrotransposon insertion mutants revealed that NiCK4 promotes nodule organogenesis. Together, these results suggest that the identified RLCK, NiCK4, acts as a component of the Nod factor signaling pathway downstream of NFR5.
Ultraviolet imaging of the anode attachment in transferred-arc plasma cutting (1999)

The anode phenomena occurring at the location of current transfer from the plasma jet to the plate affects cut quality in plasma cutting of mild steel plate. To understand these phenomena, an ultraviolet imaging technique was used to visualize the anode attachment spot under various cutting conditions. This technique has provided a unique view and fostered a better understanding of the plasma-arc cutting process.
Hotspot Based Yield Prediction with Consideration of Correlations (2008)

Design for manufacturability and yield has becomes a major issue for advanced VLSI technology nodes. The demand for a yield prediction capability has been growing significantly. Unfortunately, systematic yield prediction and analysis is still behind in both research and availability of commercial tools. A major reason for that is the high dependency of such research on hard to come by data from fabs. Thus a new approach that limits this dependency is needed. In this paper, we propose a novel and practical approach that enables systematic yield prediction with limited fab information and data. This approach is based on the information of hotspot definitions and their yield scores. The required inputs are more practical and realistic and less confidential. The dependency on the fab data is minimal. In this approach, we propose an algorithm that properly incorporates spatial correlations between yield variables when computing full chip total yield. The predicted total yield score is accurate and robust. We further demonstrate the high level of accuracy by both theory and simulation.
Hydro thermal synthesis and electrochemical characterization of (V1/2Sb1/2Sn)O4 and (Fe1/2Sb1/2Sn)O4 as energy storage materials (2021)

This paper reports the hydrothermal synthesis of alloy anode materials (V1/2Sb1/2Sn)O4 and (Fe1/2Sb1/2Sn)O4 and determine the effect of heat treatment on reversible capacities of the two oxides, and evaluation of their electrochemical properties. The compounds were initially prepared using the hydrothermal method at 180°C, and part of the active materials were reheated at 500°C in the air to improve the crystallinity and reduce the impurities. The materials were characterized by X-ray diffraction, scanning electron microscopy (SEM), Raman spectroscopy, and BET surface area. Anodic electrochemical behavior was examined by cyclic voltammetry (CV), galvanostatic cycling, and electrochemical impedance spectroscopy (EIS). Results show that (Fe1/2Sb1/2Sn)O4 reheated at 500°C delivers a better capacity of ∼400 mAh/g at 0.005-1.0 V voltage range up to 60th cycle. When we cycled a higher cut-off voltage of 0.005-3.0V, higher reversible capacity and higher capacity fading were noted due to alloying and conversion reaction of these mixed oxides. Cyclic voltammetry studies show reversible alloying/de-alloying peaks at ∼0.25 and ∼0.5 V vs. Li
Terpentecin, an inhibitor of DNA synthesis. (1988)

Terpentecin at a concentration of 0.78 microgram/ml decreased the number of viable cells of Escherichia coli NIHJ to less than one thousandth the starting number in an hour when added to an exponentially growing culture in a nutrient broth. During this time, the turbidity of the cell suspension kept increasing as fast as the control. Microscopic inspection of the cells exposed to terpentecin under these conditions revealed that the cells were elongated. Terpentecin at a concentration of 6.25 micrograms/ml inhibited incorporation of [14C]thymidine into the acid-insoluble material of cells of E. coli NIHJ by 70% in 30 minutes in contrast to little or no inhibition of the incorporation of [14C]uridine or [14C]leucine. Under similar conditions, terpentecin did not inhibit either membrane transport (uptake) of [14C]thymidine into the cells or the metabolic conversion of the precursor into various cellular acid-soluble components. Terpentecin at a higher concentration (70 micrograms/ml) inhibited by 40% in 30 minutes the incorporation of [methyl-3H]thymidine triphosphate into the DNA fraction of toluene-treated cells of E. coli JE6296 (pol A-). Terpentecin showed stronger antibacterial activities against Bacillus subtilis M45T (rec-) and E. coli BE1121 (rec A-) than against their corresponding wild type strains. However, terpentecin showed no mutagenicity by the Ames test with Salmonella typhimurium strains TA100, TA98, TA92, TA1538, TA1537 and TA1535, and with E. coli WP2 (uvr A). Terpentecin at a lower concentration (0.07 micrograms/ml) inhibited growth in vitro of mouse leukemia L1210 cells by 50%. With the mammalian cells again the incorporation of [14C]thymidine into the acid-insoluble cell material was inhibited more strongly than incorporation of [14C]uridine and [14C]leucine. There was no sign of mutagenicity by the micronucleus test using mice.
Search for massive supersymmetric particles decaying to many jets using the ATLAS detector inppcollisions ats=8  TeV (2015)

Results of a search for decays of massive particles to fully hadronic final states are presented. This search uses 20.3 fb -1 of data collected by the ATLAS detector in ffiffi ffi s p 8 TeV proton-proton collisions at the LHC. Signatures based on high jet multiplicities without requirements on the missing transverse momentum are used to search for R-parity-violating supersymmetric gluino pair production with subsequent decays to quarks. The analysis is performed using a requirement on the number of jets, in combination with separate requirements on the number of b-tagged jets, as well as a topological observable formed from the scalar sum of the mass values of large-radius jets in the event. Results are interpreted in the context of all possible branching ratios of direct gluino decays to various quark flavors. No significant deviation is observed from the expected Standard Model backgrounds estimated using jet counting as well as data-driven templates of the total-jet-mass spectra. Gluino pair decays to ten or more quarks via intermediate neutralinos are excluded for a gluino with mass m g < 1 TeV for a neutralino mass m 0 1 500 GeV. Direct gluino decays to six quarks are excluded for m g < 917 GeV for light-flavor final states, and results for various flavor hypotheses are presented.
A 14b PCM DAC (1982)

A 14b digital-to-analog converter, employing a fine/course slope technique, fabricated in standard monolithic bipolar technology, will be reported. System features a precision sample and hold amplifier and post package trim resulting in 0.003% nonlinearity. Conversion time is 20μ.
Enterprise Mobility Reference Architecture (2016)

The smart phone has become one of the most important devices in our day to day lives. Mobility is also impacting business significantly and most enterprises are providing services to facilitate the mobile workforce. This chapter introduces an enterprise mobility reference architecture. The architecture highlights the key aspects of enterprise mobility such as platform and application development, end user support, collaboration, virtualization, mobile security, monitoring and mobile analytics. The architecture is presented from several viewpoints to cater to different needs of clients. The relationship of the mobile architecture to a cloud reference architecture is also explained. Finally, a use case to demonstrate how a real world scenario maps to the architecture is also discussed.