gebhart/patrepeval huggingface dataset:
Tuning conformational asymmetry in particle-forming diblock copolymer alloys (2022)

Self-consistent field theory is employed to compute the phase behavior of binary blends of conformationally asymmetric, micelle-forming diblock copolymers with miscible corona blocks and immiscible core blocks (a diblock copolymer "alloy"). The calculations focus on establishing conditions that promote the formation of Laves phases by tuning the relative softness of the cores of the two different Laves phase particles <i>via</i> independent control of their conformational asymmetries. Increasing the conformational asymmetry of the more spherical particles of the Laves structure has a stabilizing effect, consistent with the expectations of increased imprinting of the Wigner-Seitz cells on the core/corona interface as conformational asymmetry increases. The resulting phase diagram in the temperature-blend composition space features a more stable Laves phase field than that predicted for conformationally symmetric systems. The phase field closes at low temperatures in favor of macrophase separation between a hexagonally-packed cylinder (hex) phase and a body-centered cubic phase. Companion calculations, using an alloy whose components do not produce a hex phase in the neat melt state, suggest that the Laves phase field in such a blend will persist at strong segregation.
Joint Least-Squares RTM of Surface Seismic and Seismic-While-Drilling Datasets (2019)

Summary Least-squares migration can, in theory, reduce the acquisition footprint and improve the illumination of the subsurface structures. However, in complex subsurface structures, rays or the wave energy will penetrate poorly in some regions, e.g., subsalt region, and that region will be a shadow zone to a typical surface seismic acquisition. The shadow zone is in the null space of the migration operator and the subsurface information in that region will not be recovered even by posing imaging as an inverse problem. To rectify this, we use another set of data, along with surface seismic dataset, whose ray paths are different from the surface seismic. Seismic-while-drilling (SWD) dataset are complementary to surface data, and it brings an opportunity to address seismic illumination issue by adding new measurements into the imaging problem. Accordingly, in this research, we formulate the joint least-squares reverse time migration of surface seismic and SWD datasets and explore its potential in imaging the parts of the model that is in the shadow zone of the surface seismic acquisition. Presented results on the BP-Model94 show that the joint least-squares migration outperforms the single surface and single SWD least-squares migrations in improving the illumination of subsurface structures.
High-Speed Tracking Method Using Zero Phase Error Tracking-Feed-Forward (ZPET-FF) Control for High-Data-Transfer-Rate Optical Disk Drives (2004)

We describe the effectiveness of feed-forward control using the zero phase error tracking method (ZPET-FF control) of the tracking servo for high-data-transfer-rate optical disk drives, as we are developing an optical disk system to replace the conventional professional videotape recorder for recording high-definition television signals for news gathering or producing broadcast contents. The optical disk system requires a high-data-transfer-rate of more than 200 Mbps and large recording capacity. Therefore, fast and precise track-following control is indispensable. Here, we compare the characteristics of ZPET-FF control with those of conventional feedback control or repetitive control. Experimental results show that ZPET-FF control is more precise than feedback control, and the residual tracking error level is achieved with a tolerance of 10 nm at a linear velocity of 26 m/s in the experimental setup using a blue-violet laser optical head and high-density media. The feasibility of achieving precise ZPET-FF control at 15000 rpm is also presented.
N-Substituted Corroles: A Novel Class of Chiral Ligands (1999)

Although known for almost 35 years, N-substituted corroles have only now been recognized as being chiral. Several examples of these species were prepared in a facile two-step synthesis and separated into their enantiomers by HPLC. The zinc(II) complex of the corrole shown schematically was also synthesized.
Implicit network timing synchronization with phase-only updates (2011)

Timing synchronization is a critical requirement for implementation of a number of performance-enhancing strategies in mesh networks, including Time Division Multiplexing (TDM) for more efficient resource usage, and sleep scheduling for power efficiency. In this paper, we propose a simple algorithm for overhead-free maintenance of timing synchronization and investigate its scalability with the size of the network. In the proposed scheme, the nodes only use information obtained from the timing of existing communication in the network: each node updates only its clock phase when it receives a packet, depending on the difference between the expected and actual packet arrival times. The uncompensated frequency differences across nodes lead to irreducible phase errors, which we bound by introducing the notion of an averaged system. We use a linear programming formulation to show that these phase errors can grow with the network size, thereby concluding that simple, phase-only adjustments might suffice to maintain synchrony in small networks, but additional frequency adjustments are necessary for larger networks.
Timing yield estimation from static timing analysis (2002)

This paper presents a means for estimating parametric timing yield and guiding robust design for-quality in the presence of manufacturing and operating environment variations. Dual emphasis is on computational efficiency and providing meaningful robust-design guidance. Computational efficiency is achieved by basing the proposed methodology on a post-processing step applied to the report generated as a by-product of static timing analysis. Efficiency is also ensured by exploiting the fact that for small processing/environment variations, a linear model is adequate for capturing the resulting delay change. Meaningful design guidance is achieved by analyzing the timing-related influence of variations on a path-by-path basis, allowing designers perform a quality-oriented design pass focused on key paths. A coherent strategy is provided to handle both die-to-die and within-die variations. Examples from a PowerPC microprocessor illustrate the methodology and its capabilities.
FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities (2016)

Recent gene-profiling analyses showed significant upregulation of the folate hydrolase (<i>FOLH1</i>) gene in the affected intestinal mucosa of patients with inflammatory bowel disease (IBD). The <i>FOLH1</i> gene encodes a type II transmembrane glycoprotein termed glutamate carboxypeptidase II (GCPII). To establish that the previously reported increased gene expression was functional, we quantified the glutamate carboxypeptidase enzymatic activity in 31 surgical specimens and report a robust 2.8- to 41-fold increase in enzymatic activity in the affected intestinal mucosa of IBD patients compared with an uninvolved area in the same patients or intestinal mucosa from healthy controls. Using a human-to-mouse approach, we next showed a similar enzymatic increase in two well-validated IBD murine models and evaluated the therapeutic effect of the potent <i>FOLH1</i>/ GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) (IC<sub>50</sub> = 300 pM). In the dextran sodium sulfate (DSS) colitis model, 2-PMPA inhibited the GCPII activity in the colonic mucosa by over 90% and substantially reduced the disease activity. The significance of the target was confirmed in <i>FOLH1<sup>-/-</sup></i> mice who exhibited resistance to DSS treatment. In the murine IL-10<sup>-/-</sup> model of spontaneous colitis, daily 2-PMPA treatment also significantly reduced both macroscopic and microscopic disease severity. These results provide the first evidence of <i>FOLH1</i>/GCPII enzymatic inhibition as a therapeutic option for IBD.
Seasonal differences in resting oxygen consumption, respiratory quotient, and free thyroxine in woodchucks (1998)

The relationships among seasonal differences in body weight, food intake, metabolism, and thyroid hormone in woodchucks were investigated in 12 woodchucks. Six woodchucks had been maintained on a photoperiod simulating that found at 42 degrees N (boreal woodchucks). The other group of six animals had been maintained similarly in all respects except that the light simulated that found at 42 degrees S (austral woodchucks). An openflow respirometer, calibrated using the N2-dilution method, was used to determine metabolism twice in a 2-wk period near the September equinox, while at the same time food intake, body weight, and free thyroxine concentrations (fT4) were measured. Body weight was the same for both groups of woodchucks. However, compared with boreal animals near their autumnal equinox, austral woodchucks near their vernal equinox had significantly higher (P < 0.01) daily food intake (5 +/- 2 vs. 35 +/- 2 g.kg-1.day-1), oxygen consumption (4.4 +/- 0.3 vs. 7.3 +/- 0.3 ml.min-1.kg-1), carbon dioxide production (2.8 +/- 0.2 vs. 6.0 +/- 0.2 ml.min-1.kg-1), respiratory quotient (0.65 +/- 0.01 vs. 0.82 +/- 0.02), and fT4 (0.21 +/- 0.01 vs. 0.65 +/- 0.05 ng/dl). It was concluded that photoperiod has a strong effect on resting metabolism in the woodchuck and that there is an association between fT4 and changes in food intake and metabolic rate.
Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance (2018)

These findings not only suggest a model whereby HMGB1 interacts with TLR4/MD-2 in a two-stage process but also explain how the A-box domain and 2G7 inhibit HMGB1.
All-fibre, 2ps Yb laser with 60kW peak power (2004)

We demonstrate a 2-20ps pulse duration fibre laser in the Yb-wavelength range with up to 60kW peak and 9W average powers. Pulses from a self-starting, ring-fibre-cavity Yb laser with spectral gain/pulse-duration control were amplified in 2m-long, Yb-doped fiber.
[Optic nerve head and choroidal circulation measured by laser Doppler flowmetry in response to intravenous administration of noradrenaline]. (1997)

We investigated the change of optic nerve head blood flow (ONHBF) and choroidal blood flow (CBF) in response to noradrenaline (NA) intravenously administered in anesthetized cats. NA (0.03, 0.1, 0.3 micrograms/kg/min) was injected 5 minutes continuously via the femoral vein. The relative blood flow and systemic blood pressure were continuously measured before and after NA administration with fundus camera-based laser Doppler flowmetry. Systemic blood pressure increased by 6%, 42% and 48% according to the dose. The changes in ONHBF after NA administration were -1.4 +/- 3.5% (mean +/- standard deviation) with 0.03 micrograms/kg/min, 2.4 +/- 6.9% with 0.1 micrograms/kg/min, -2.2 +/- 4.4% with 0.3 micrograms/kg/min, respectively. It did not change significantly despite doses of NA. CBF did not change significantly with 0.03 micrograms/kg/min. CBF increased significantly by 62.7 +/- 65.4% with 0.1 micrograms/kg/min, and 80.4 +/- 73.1% with 0.3 micrograms/kg/min. These results suggest that ONHBF is autoregulated despite the change of perfusion pressure by NA administration. This response is different from that of CBF.
ChemInform Abstract: New 8‐(Trifluoromethyl)‐Substituted Quinolones. The Benefits of the 8‐ Fluoro Group with Reduced Phototoxic Risk. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Candidate Selection and Preclinical Evaluation of N - tert -Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century (2009)

N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and developed as part of a public-private partnership between academics at Liverpool, MMV, and GSK pharmaceuticals. This molecule was rationally designed based on chemical, toxicological, pharmacokinetic, and pharmacodynamic considerations and was selected based on excellent activity against Plasmodium falciparum in vitro and rodent malaria parasites in vivo. The optimized chemistry delivered this novel synthetic quinoline in a two-step procedure from cheap and readily available starting materials. The molecule has a full industry standard preclinical development program allowing first into humans to proceed. Employing chloroquine (1) and amodiaquine (2) as comparator molecules in the preclinical plan, the first preclinical dossier of pharmacokinetic, toxicity, and safety pharmacology has also been established for the 4-aminoquinoline antimalarial class. These studies have revealed preclinical liabilities that have never translated into the human experience. This has resulted in the availability of critical information to other drug development teams interested in developing antimalarials within this class.
Immunogenicity of the Plasmodium falciparum glutamate-rich protein expressed by vaccinia virus (1994)

The glurp gene of Plasmodium falciparum F32 has been inserted into a vaccinia virus, and the recombinant virus was designated VVG4. Expression of glurp in VVG4-infected Vero cells was analyzed by immunoprecipitation and revealed a primary GLURP product of approximately 220,000 Da; GLURP was detected both intracellularly and in culture supernatants. To study the immunogenicity of vaccinia virus-expressed GLURP, mice were immunized with VVG4 and serum samples were analyzed for antibody reactivity with three polypeptides, covering almost the entire GLURP molecule; these three polypeptides were produced in recombinant form in Escherichia coli. The immune response was primarily directed against a carboxy-terminal repeat region. The mouse anti-GLURP serum recognized authentic GLURP by immunoprecipitation analysis from P. falciparum grown in vitro. These results demonstrate that vaccinia virus-expressed glurp product can induce a humoral immune response against GLURP derived from blood-stage parasites.
Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes (2006)

The subrenal capsule xenograft approach essentially provides a living tumor bank derived from patient material and a means for isolating and expanding specific cell populations. The transplantable tumor lines seem to provide good models for studying various aspects of tumor progression and a platform for developing novel therapeutic regimens, with the possibility of patient-tailored therapies.
Identification of Multichannel Cardiovascular Dynamics Using Dual Laguerre Basis Functions for Noninvasive Cardiovascular Monitoring (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a novel method to identify the cardiovascular (CV) system using two distinct peripheral blood pressure (BP) signals. The method can characterize the distinct arterial path dynamics that shape each of the BP signals and recover the common central-flow signal fed to them. A Laguerre series data-compression technique is used to obtain a compact representation of the CV system, whose coefficients are identified using the multichannel blind system identification. A Laguerre model deconvolution algorithm is developed to stably recover the central-flow signal. Persistent excitation, model identifiability, and asymptotic variance are analyzed to quantify the method's validity and reliability, without using any direct measurement of central-flow input signal. Experimental results based on 7000 data segments obtained from nine swine subjects show that, for all the swine subjects under diverse physiologic conditions, the CV dynamics can be identified very reliably and the waveform of the central flow can be recovered stably from peripheral BP signals. </para>
Image sensor for compression and enhancement (2002)

In this paper, we propose a novel image sensor on which a video signal can be compressed. By making use of very fast analog processing on the imager plane, the compression sensor can significantly reduce the amount of pixel data output from the sensor. A prototype sensor with 32/spl times/32 pixels has been fabricated using standard 2 /spl mu/m CMOS technology. Some results of examinations are shown in this paper. We also describe a motion adaptive enhancement sensor which controls storage time independently pixel by pixel. The proposed sensor is intended to have high temporal resolution in the moving area and high SNR in the static area. According to preliminary experiments, the value of SNR increases about 5 dB compared to the video compression sensor.
Methanol extract of Hydroclathrus clathratus suppresses matrix metalloproteinase-9 in T24 bladder carcinoma cells by suppressing the NF-κB and MAPK pathways (2011)

Hydroclathrus clathratus is a brown marine seaweed and its extract possessing anti-cancer, anti-herpetic and anti-coagulant activities is a traditional drug and health food in Korea, Japan and China. However, little is known about the mechanism by which the methanol extract of H. clathratus (MEHC) inhibits invasion of cancer cells. In the present study, we investigated the effects of MEHC on the expression of matrix metalloproteinase-9 (MMP-9) in T24 human bladder carcinoma cells. Our findings showed that MMP-9 activity was significantly increased in response to tumor necrosis factor-α (TNF-α). However, treatment with MEHC substantially reversed TNF-α-induced MMP-9 activity. A matrigel invasion assay also showed that MEHC reduced TNF-α-induced invasion of T24 bladder carcinoma cells. We also found that MEHC significantly downregulated the expression of the MMP-9 gene induced by TNF-α stimulation. Furthermore, we investigated the effects of MEHC on nuclear factor (NF)-κB activity, which is a potential transcriptional factor for regulating many invasive genes including MMP-9. MEHC suppressed NF-κB activity by suppressing IκB degradation and nuclear translocation of the NF-κB p65 and p50 subunits. TNF-α-induced phosphorylation of phosphatidyl-inositol 3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) was significantly downregulated in the presence of MEHC. Taken together, these results indicate that MEHC is a potential anti-invasive agent by suppressing TNF-α-induced cancer cell invasion and by specifically inhibiting NF-κB and MAPKs, as well as downstream target genes such as MMP-9.
Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals (2021)

Sperm-zona pellucida (ZP) interaction, involving the binding of sperm surface ligands to complementary carbohydrates of ZP, is the first direct gamete contact event crucial for subsequent gamete fusion and successful fertilization in mammals. It is a complex process mediated by the coordinated engagement of multiple ZP receptors forming high-molecular-weight (HMW) protein complexes at the acrosomal region of the sperm surface. The present article aims to review the current understanding of sperm-ZP binding in the four most studied mammalian models, i.e., murine, porcine, bovine, and human, and summarizes the candidate ZP receptors with established ZP affinity, including their origins and the mechanisms of ZP binding. Further, it compares and contrasts the ZP structure and carbohydrate composition in the aforementioned model organisms. The comprehensive understanding of sperm-ZP interaction mechanisms is critical for the diagnosis of infertility and thus becomes an integral part of assisted reproductive therapies/technologies.
Plague Bacteria Target Immune Cells During Infection (2005)

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.
Excimer laser machining by a multiple imaging system using holographic optical elements (1996)

Summary form only given. We propose excimer laser machining using a multiple imaging system employing a holographic optical element (HOE). The multiple imaging system can generate many images from one mask pattern. The HOEs that we used were computer-generated phase holograms, the so-called kinoform type. Their diffraction efficiency can theoretically reach 100%.
Compositionally Enhanced Flexibility in a Ga-Rich Zeolite Affords Unusual Structural Changes via Alkali Ion Exchange (2015)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCompositionally Enhanced Flexibility in a Ga-Rich Zeolite Affords Unusual Structural Changes via Alkali Ion ExchangeSung Man Seo†, Nak Ho Ahn†, Jiho Shin†, Sung June Cho‡, Miguel A. Camblor§, and Suk Bong Hong*†View Author Information† Center for Ordered Nanoporous Materials Synthesis, School of Environmental Science and Engineering, POSTECH, Pohang 790-784, Korea‡ Department of Applied Chemical Engineering, Chonnam National University, Gwangju 500-757, Korea§ Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain*(S.B.H.) E-mail: [email protected]Cite this: Chem. Mater. 2015, 27, 18, 6177–6180Publication Date (Web):August 28, 2015Publication History Received17 July 2015Revised28 August 2015Published online1 September 2015Published inissue 22 September 2015https://pubs.acs.org/doi/10.1021/acs.chemmater.5b02741https://doi.org/10.1021/acs.chemmater.5b02741rapid-communicationACS PublicationsCopyright © 2015 American Chemical SocietyRequest reuse permissionsArticle Views779Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cations,Crystals,Flexibility,Ion exchange,Zeolites Get e-Alerts