gebhart/patrepeval huggingface dataset:
Characterization of the Inflammatory-Metabolic Phenotype of Heart Failure with a Preserved Ejection Fraction: A Hypothesis to Explain Influence of Sex on the Evolution and Potential Treatment of the Disease (2020)

Accumulating evidence points to the existence of an inflammatory-metabolic phenotype of heart failure with a preserved ejection fraction (HFpEF), which is characterized by biomarkers of inflammation, an expanded epicardial adipose tissue mass, microvascular endothelial dysfunction, normal-to-mildly increased left ventricular volumes and systolic blood pressures, and possibly, altered activity of adipocyte-associated inflammatory mediators. A broad range of adipogenic metabolic and systemic inflammatory disorders - e.g. obesity, diabetes and metabolic syndrome as well as rheumatoid arthritis and psoriasis - can cause this phenotype, independent of the presence of large vessel coronary artery disease. Interestingly, when compared with men, women are both at greater risk of and may suffer greater cardiac consequences from these systemic inflammatory and metabolic disorders. Women show disproportionate increases in left ventricular filling pressures following increases in central blood volume and have greater arterial stiffness than men. Additionally, they are particularly predisposed to epicardial and intramyocardial fat expansion and imbalances in adipocyte-associated proinflammatory mediators. The hormonal interrelationships seen in inflammatory-metabolic phenotype may explain why mineralocorticoid receptor antagonists and neprilysin inhibitors may be more effective in women than in men with HFpEF. Recognition of the inflammatory-metabolic phenotype may improve an understanding of the pathogenesis of HFpEF and enhance the ability to design clinical trials of interventions in this heterogeneous syndrome.
Antitachycardia pacing success in implantable cardioverter-defibrillators by patient, device, and programming characteristics (2022)

Delivering more ATP sequences resulted in a higher overall success of terminating VTs, while programming more ATP was associated with decreased shock burden and no evidence of increased syncope or acceleration. This suggests that more ATP sequences should be programmed when possible, but confirmation in prospective studies will be necessary.
Characterization of the spatial distributions of entrapped polymers following the surface engineering of poly(lactic acid) (2001)

Abstract In earlier studies we have demonstrated physical entrapment as a method of surface‐modifying poly(lactic acid) (PLA) by immobilizing poly( L ‐lysine) (PLL) and poly(ethylene glycol) (PEG) at the PLA surface. In this study, we have used a combination of time‐of‐flight (ToF) SIMS and XPS image analysis to determine the surface homogeneity of these systems. The ToF‐SIMS imaging was used to investigate the effect of various surface‐engineering conditions on the lateral distribution of PLL‐modified PLA. The PLA surface modification was revealed to produce micron‐scale PLL‐rich domains following prolonged exposure to the partial solvent system that is used during the entrapment process. As the static SIMS analysis of PEG/PLA surfaces did not produce distinguishing ions of a sufficient intensity between the two polymers, this technique could not generate lateral contrast, and imaging XPS was therefore employed to determine the surface distributions of these two species. Phase separation was again detected under extended surface engineering conditions. With both systems, optimization of the process conditions was shown to inhibit the creation of a heterogeneous surface. Surface segregation may result in suboptimal performance of the biomaterial and this study therefore highlights the importance of determining spatial organizations when modifying polymer interfaces. Copyright © 2001 John Wiley &amp; Sons, Ltd.
An 8- × 10-Gb/s 42-km High-Split TWDM PON Featuring Distributed Raman Amplification and a Remotely Powered Intelligent Splitter (2017)

We demonstrate an intelligent symmetric-rate 8- × 10-Gb/s bidirectional time and wavelength-division multiplexed passive optical network with 42-km reach and 1:256 split 1425-nm laser pump light provides distributed Raman amplification for the upstream channels (allowing low-cost low-power transmitters), serves as a low-rate telemetry channel, and powers an intelligent splitter module that provides supervision for mission-critical services.
Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock (2023)

This improved genomic resource is suitable as a foundation for the identification of potential targets for vaccine and drug development.
The Case for Transmitter Training (2006)

Transmitter side information enables techniques such as beamforming, power control, and rate control in fading channels. It is commonly accepted in the literature that the addition of transmitter information (CSIT) to receiver information (CSIR) provides better performance than receiver information alone. In this work, we examine the performance of a symmetric, single-input, multiple-output (SIMO) channel in which CSIT is acquired through the use of training symbols, and we have a genie-aided receiver. We give a closed form expression for outage probability at high SNR while accounting for the resources consumed by training. We also analyze the diversity-multiplexing tradeoff and find that, though the diversity falls far below that of systems with perfect CSIT, it is still sufficiently superior to that achieved by CSIR-only systems to justify the cost of training. We show that, at zero multiplexing, transmitter training doubles the diversity order of a CSIR-only system and offers nonzero diversity at all achievable multiplexing gains
Organic Molecules—Electronic Structures, Properties, and Reactions (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma (2004)

Multiple myeloma (MM) cells express certain tumour-associated antigens (TAAs) that could serve as targets for active-specific immunotherapy. The aim of the present study was to test the MM/dendritic cell (DC) fusion as a vaccination strategy. We fused MM cells with DC to generate fusion cells (FCs) and tested their antigen presenting cell (APC) function in mixed lymphocyte reactions and cytotoxicity assays. First, the HS Sultan and SK0-007 HAT sensitive human MM cell lines and DCs generated from peripheral blood of normal donors were fused in the presence of 50% polyethylene glycol to form FCs. Next, tumour cells freshly isolated from patients were similarly fused with autologous DCs to generate FCs. The FCs demonstrated a biphenotypic profile, confirmed both by flow-cytometry and dual immunofluorescence microscopy. These FCs induced MM-specific cytotoxicity. FCs, but not MM cells or DCs alone, were potent stimulators of autologous patient T cells. More importantly, FC-primed autologous peripheral blood mononuclear cells demonstrated major histocompatibility complex-restricted MM-specific cytolysis. These studies therefore demonstrated that MM/DC FC can trigger an autologous immune response to MM cells and formed the framework for a clinical trial currently underway.
PARVOVIRUS B19-ASSOCIATED RED BLOOD CELL APLASIA IN COMBINED IMMUNODEFICIENCY WITH NORMAL IMMUNOGLOBULINS (1994)

Tang, Mimi L. K. M.B.B.S.; Kemp, Andrew S. FRACP, Ph.D.; Moaven, Len D. M.B.B.S. Author Information
Maternal diesel particle exposure promotes offspring asthma through NK cell–derived granzyme B (2020)

Mothers living near high-traffic roads before or during pregnancy are more likely to have children with asthma. Mechanisms are unknown. Using a mouse model, here we showed that maternal exposure to diesel exhaust particles (DEP) predisposed offspring to allergic airway disease (AAD, murine counterpart of human asthma) through programming of their NK cells; predisposition to AAD did not develop in DEP pups that lacked NK cells and was induced in normal pups receiving NK cells from WT DEP pups. DEP NK cells expressed GATA3 and cosecreted IL-13 and the killer protease granzyme B in response to allergen challenge. Extracellular granzyme B did not kill, but instead stimulated protease-activated receptor 2 (PAR2) to cooperate with IL-13 in the induction of IL-25 in airway epithelial cells. Through loss-of-function and reconstitution experiments in pups, we showed that NK cells and granzyme B were required for IL-25 induction and activation of the type 2 immune response and that IL-25 mediated NK cell effects on type 2 response and AAD. Finally, experiments using human cord blood and airway epithelial cells suggested that DEP might induce an identical pathway in humans. Collectively, we describe an NK cell-dependent endotype of AAD that emerged in early life as a result of maternal exposure to DEP.
A depth of interaction detector for PET with GSO crystals doped with different amounts of Ce (2002)

A new method for a four-stage depth of interaction (DOI) detector is proposed. The four-stage DOI detector is constructed with two kinds of Gd/sub 2/SiO/sub 5/:Ce (GSO) crystals doped with different amounts of Ce, 0.5 mol% and 1.5 mol%. The amount of Ce in GSO determines the scintillation decay time constant, and it is 60 ns for the 0.5 mol% GSO and 35 ns for 1.5 mol% GSO. This difference led to the introduction of pulse-shape discrimination, which would distinguish between two kinds of event data from respective GSOs and sort them into two groups. By independently applying Anger-type position arithmetic to the data of each group, two two-dimensional (2-D) histograms are obtained. The crystal of interaction can be identified on these histograms in which only 0.5 mol% or 1.5 mol% GSO crystal elements are expressed. To evaluate this method, we constructed the four-stage DOI detector by alternately stacking 1.5 mol% GSO crystal stages and 0.5 mol% stages. The result of a scanning measurement with a /sup 137/Cs gamma-ray beam proved that the DOI detector had enough accuracy in crystal identification.
Radiated Sound Power from a Curved Honeycomb Panel (2003)

The validation of finite element and boundary element model for the vibro-acoustic response of a curved honeycomb core composite aircraft panel is completed. The finite element and boundary element models were previously validated separately. This validation process was hampered significantly by the method in which the panel was installed in the test facility. The fixture used was made primarily of fiberboard and the panel was held in a groove in the fiberboard by a compression fitting made of plastic tubing. The validated model is intended to be used to evaluate noise reduction concepts from both an experimental and analytic basis simultaneously. An initial parametric study of the influence of core thickness on the radiated sound power from this panel, using this numerical model was subsequently conducted. This study was significantly influenced by the presence of strong boundary condition effects but indicated that the radiated sound power from this panel was insensitive to core thickness primarily due to the offsetting effects of added mass and added stiffness in the frequency range investigated.
A malignant astrocytoma containing simian virus 40 DNA in a macaque infected with simian immunodeficiency virus (1997)

Polyomaviruses have proven oncogenicity in nonhost experimental animals; however, studies concerning the association between human brain tumors and simian and human polyomaviruses have yielded inconclusive results. We examined the relationship of SV40 to a malignant astrocytoma found in the right frontal lobe of a pigtail macaque (Macaca nemestrina) infected with simian immunodeficiency virus (SIV). Consistent with the histologic diagnosis, the tumor was immunoreactive with antibodies to S-100 protein, vimentin, and glial fibrillary acidic protein, but negative for neurofilament protein, synaptophysin, neuron-specific enolase, and chromogranin A. At the time of SIV inoculation, the animal was seropositive for SV40. Polymerase chain reaction assay of tumor DNA, but not normal brain DNA, yielded a 300 base-pair fragment corresponding to the carboxy-terminal coding region (C-terminus) of the large T antigen gene of SV40, suggesting an association with the tumor.
Robust affine structure matching for 3D object recognition (1998)

We consider model-based object localization based on local geometric feature matching between the model and the image data. The method is based on geometric constraint analysis, working in transformation space. We present a formal method which guarantees finding all feasible matchings in polynomial time. From there we develop more computationally feasible algorithms based on conservative approximations of the formal method. Additionally, our formalism relates object localization, affine model indexing, and structure from multiple views to one another.
Stellar Imager (SI): developing and testing a predictive dynamo model for the Sun by imaging other stars (2010)

The Stellar Imager mission concept is a space-based UV/Optical interferometer designed to resolve surface magnetic activity and subsurface structure and flows of a population of Sun-like stars, in order to accelerate the development and validation of a predictive dynamo model for the Sun and enable accurate long-term forecasting of solar/stellar magnetic activity.
Robust microfabricated surface ion traps with arbitrary geometries. (2011)

Abstract not provided.
Correction: High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing (2022)

Correction for 'High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing' by Bo Zhang <i>et al.</i>, <i>Analyst</i>, 2020, <b>145</b>, 5733-5739, DOI: 10.1039/D0AN00813C.
Partitioning of minor actinides from HLLW using the DIAMEX process.Part 2 - ´´Hot´´ continuous counter-current experiment (2000)

Among several processes proposed world-wide, the French DIAMEX (DIAMide EXtraction) process seems to be very efficient for the removal of Minor Actinides (MA) from genuine High Level Liquid Waste (HLLW). The MA are in this process directly extracted from the PUREX (Plutonium Uranium Redox EXtraction) raffinate together with fission lanthanides using the completely combustible diamide extractant. In this work a hot demonstration of the DIAMEX process using genuine high-level PUREX raffinate is reported. The continuous counter-current experiment was carried out in a 16 stage centrifugal extractor battery, installed in a hot cell. In order to produce a representative HLLW a PUREX process was applied on dissolved fuel using the same equipment. In the DIAMEX process up to 6 extraction stages were sufficient to achieve feed decontamination factors between 100 and 230 for lanthanides and above 300 for minor actinides. Co-extraction of molybdenum and zirconium were efficiently prevented using oxalic acid scrubbing. The back extraction proved to be very efficient, yielding in 4 stages more than 99.9% recovery of both the lanthanides and the actinides. Co-extracted ruthenium, technetium, palladium and neptunium are less efficiently back-extracted requiring further process development.
acDCs enhance human antigen–specific T-cell responses (2011)

Detection of human Ag-specific T cells is limited by sensitivity and blood requirements. As dendritic cells (DCs) can potently stimulate T cells, we hypothesized that their induction in PBMCs in situ could link Ag processing and presentation to Ag-specific T-cell activation. To this end, unfractionated PBMCs (fresh or frozen) or whole blood were incubated for 48 hours with protein or peptide Ag together with different DC-activating agents to rapidly and sequentially induce, pulse, and mature DCs. DC activation was therefore lined up with Ag recognition by neighboring T cells, thus telescoping the sequential steps of T-cell activation. Efficient processing of protein Ags made prior knowledge of epitopes and HLA restrictions dispensable. While reducing stimulation time, manipulation and blood requirements, in situ DC induction specifically amplified Ag-specific T-cell responses (cytokine secretion, proliferation, CD137/CD154 up-regulation, and binding of peptide-HLA multimers). IL-1β, although released by DCs, was also secreted in an Ag-specific fashion, thus providing an indirect biomarker of T-cell responses. These accelerated cocultured DC (acDC) assays offered a sensitive means with which to evaluate T-cell responses to viral and melanoma Ag vaccination, and may therefore find application for immune monitoring in viral, tumor, autoimmune, and transplantation settings.
Feasibility of absolute quantification for 31P MRS at 7 T (2019)

It is essential to select a calibration phantom with appropriate conductivity for quantitative phosphorus spectroscopy at 7 T. Using an 18-mM phosphate phantom and simplified normalization, human liver phosphate metabolite concentrations were successfully quantified at 7 T.
L‐5: Late‐News Paper : Silica Aerogel Thin Film Substrate for OLED (2001)

Abstract Silica aerogel thin film with extremely low refractive index was formed on the glass substrate by sol‐gel coating and supercritical drying. Using this substrate, we fabricated the OLED and observed the disappearance of wave‐guiding propagation within the glass substrate and the improvement of the coupling‐out efficiency.
Mortality trend for liver cancer in a hyperendemic area of hepatitis C virus infection in southern Italy (2013)

Crispo, Annaa; Barba, Maddalenab; Malvezzi, Matteoc; Ciliberto, Gennaroa; Montella, Maurizioa Author Information
Hybrid Opportunistic Scheduling in Cognitive Radio Networks (2011)

In a cognitive (secondary) multiple-access network which is subject to interference power constraints imposed by a primary system, it is desirable to mitigate the interference on the primary and to harvest multiuser diversity gains in the secondary. To simultaneously achieve these goals, a two-step (hybrid) scheduling method is proposed that pre-selects a set of secondary users based on their interference on the primary, and from among them selects the user(s) that yield the highest secondary throughput. The optimal number of active secondary transmitters is characterized as a function of the primary interference constraint, the secondary transmit power, and the number of secondary transmitters n. The secondary sum-rate (throughput) of the proposed algorithm grows optimally (proportional to log n). We investigate the tradeoff between scaling the secondary throughput and reducing interference on the primary, and characterize the optimum tradeoff in the regime of large n. Finally, we study user scheduling under fairness constraints, which is necessary when the channel statistics of secondary nodes are not identical. A modified hybrid scheduling rule is proposed to ensure user fairness, while still achieving the optimal growth rate for the secondary throughput.
Simple autocorrelation technique based on degree-of-polarization measurement (2006)

We demonstrate a simple optical-fiber-based autocorrelator for picosecond short pulses based on degree-of-polarization measurement while tuning the relative delay of the two orthogonal polarization states of the pulse. The pulsewidths of 20-, 40-, and 80-GHz pulse trains and 2-ps pulses generated by a mode-locked laser are measured. The <-10-dBm optical powers are used in the experiment. The measurement results agree well with the measurements using conventional techniques. Compared with conventional autocorrelators, this technique has the advantages of 1) wavelength independent, 2) significant less alignment, and 3) no high power required
Intraoperative measurement of knee kinematics in reconstruction of the anterior cruciate ligament (2002)

Our objectives were to establish the envelope of passive movement and to demonstrate the kinematic behaviour of the knee during standard clinical tests before and after reconstruction of the anterior cruciate ligament (ACL). An electromagnetic device was used to measure movement of the joint during surgery. Reconstruction of the ACL significantly reduced the overall envelope of tibial rotation (10° to 90° flexion), moved this envelope into external rotation from 0° to 20° flexion, and reduced the anterior position of the tibial plateau (5° to 30° flexion) (p &lt; 0.05 for all). During the pivot-shift test in early flexion there was progressive anterior tibial subluxation with internal rotation. These subluxations reversed suddenly around a mean position of 36 ± 9° of flexion of the knee and consisted of an external tibial rotation of 13 ± 8° combined with a posterior tibial translation of 12 ± 8 mm. This abnormal movement was abolished after reconstruction of the ACL.
Nonlinear Estimation of RespiratoryInduced Heart Movements and its Application in ECG/VCG Signal Processing (2009)

This chapter contains sections titled: Introduction Maximum Likelihood VCG Loop Alignment Loop Alignment and Morphologic Variability Sensitivity of Loop Alignment to Noise Spatiotemporal Alignment and QRST Cancellation Conclusions This chapter contains sections titled: References
Characterization of terahertz field confinement at the end of a tapered metal wire waveguide (2009)

We present experimental verification of the possibility of strong subwavelength confinement of the terahertz electric field at the end of a tapered metal wire waveguide. The axial field component at the end of the tapered waveguide shows a lateral confinement that is an order of magnitude greater than an untapered waveguide, and over 100 times greater than the free-space wavelength. The axial component is also strongly confined in the propagation direction, in contrast to the radial field component. Comparison to numerical simulation yields excellent agreement when the effect of the detecting probe is included in the analysis.
χ*, a χ‐related 11‐mer sequence partially active in an E. coli recC* strain (1997)

We have discovered that a mutant RecBCD enzyme responds, in vivo, to a longer chi variant.
New intra-video collusion attack using mosaicing (2003)

Recent efforts for watermarking digital video extend the results obtained for still image watermarking. As a result, most of the proposed algorithms rely on a frame-by-frame approach. Such an adaptation leads to unreliable algorithms in terms of security. The goal of this article is to stress the problem of collusion when digital watermarked data is distributed at large scale and especially intra-video collusion in the context of video. Three simple collusion attacks are described before being evaluated on two alternative video watermarking algorithms based on the spread spectrum technique. Finally, some experimental results are presented confirming the danger of intra-video collusion and some perspectives are discussed.
Long-chain (sphingoid) bases cause growth changes and cytotoxicity in Chinese hamster ovary cells (1987)

Long-chain bases are potent inhibitors of the CaS , phospholipid-dependent protein kinase (PKC) both in vitro and in vivo. Low concentrations of these compounds added to Chinese hamster ovary (CHO) cells stimulated the cloning efficiency and growth of these cells; concentrations up to 4 M caused a combination of growth inhibition and cytotoxicity; and, higher concentrations led to rapid cell death. Investigation into the association between long-chain base growth effects and inhibition of PKC showed that the structural specificity necessary for these effects paralleled the potency of PKC inhibition observed in other systems. Furthermore, treatment with the long-chain base sphinganine inhibited phorbol ester-induced phosphorylation changes in CHO cells while the phosphorylation patter of a mutant cell isolated for its resistance to sphinganine toxicity was unchanged by either phorbol ester or sphinganine treatment. These results strongly suggest that inhibition of PKC by long-chain bases is related to the cytotoxicity and growth effects of these compounds.