gebhart/patrepeval huggingface dataset:
Necessity of right atrial catheter ablation to terminate persistent atrial fibrillation can be predicted from a disparate prolongation of left and right atrial cycle lengths (2008)

info:eu-repo/semantics/published
Role of developmental factors in the switch from pyruvate to glucose as the major exogenous energy substrate in the preimplantation mouse embryo (2000)

Preimplantation mouse embryos, cultured in vitro and those freshly flushed from the reproductive tract, exhibit a switch in energy substrate preference, from pyruvate during the early preimplantation stages, to glucose at the blastocyst stage. Although the biochemical basis of this phenomenon is quite well characterized, its timing and possible association with developmental factors have not been considered. We have therefore examined the role of five developmental factors in determining the timing of the switch, namely: (1) embryo age (in hours post hCG); (2) developmental stage; (3) cytokinesis; (4) cell number; and (5) activation of the embryonic genome. One-cell embryos, which develop more slowly than 2-cell embryos in vitro, were used to investigate the role of embryo age and developmental stage. Cytochalasin D, which inhibits cytokinesis and delays the timing of compaction and cavitation, was used to investigate the role of cell division and developmental stage. Finally, transcription of the embryonic genome was examined with the inhibitor, alpha-amanitin. Pyruvate and glucose consumption by single embryos were measured using a noninvasive ultramicrofluorometric technique. The results showed that the timing of the switch in energy substrate preference is precisely regulated in the mouse preimplantation embryo. Activation of the embryonic genome is a prerequisite for the switch and its timing is closely associated with developmental stage, specifically compaction and/or cavitation. Cell number, cytokinesis and embryo age appeared to be unrelated to the timing of the switch. These conclusions may well be extrapolated to other species, since an increase in net glucose uptake, if not always at the expense of pyruvate, is a feature of preimplantation embryo metabolism in all mammals studied.
Syntheses of β,γ-unsaturated α-amino acids (1991)

A review article about synthetic procedures to α-amino acids with multiple bond at β,γ-position which have been developed so far. Attention is also paid to the title syntheses of optically active products.
Trapping Mechanism of Interface Crack at Concrete/Engineered Cementitious Composite Bimaterial (1997)

Peer Reviewed
ChemInform Abstract: Cycloaddition of the Trimethylenemethane‐Palladium Complex to Activated Six‐Membered and Medium‐Size Ring Enones. (1988)

Abstract The cyclohexenones (I) react with the acetoxymethylallylsilane (II) in the presence of a Pd(0) catalyst generated in situ to produce the methylenecyclopentanocyclohexanones (III).
Investigative Study of Local Sherwood Numbers Using Phase Measurement Interferometry (2004)

This paper investigates the relationship between mass and momentum transport. This study of mass transfer is an important design consideration when looking at engineering processes such as evaporation, chemical reactions, corrosion and mixing. Little is know about the relationship. Using the non-intrusive optical technique of Electronic Speckle Pattern Interferometry (ESPI), concentration profile measurements were carried out. A phase-shifting algorithm was also employed to give whole field measurements. Momentum transport in the velocity boundary layer was examined using Particle Image Velocimetry (PIV), which is also a non-intrusive optical technique. The two measurements were taken independently so as to reduce the effect that seed particles may have on the interferometric measurements. A concentration profile was developed above a surface by passing airflow across a flat plate containing a well of ethanol. The rate of mass transfer is obtained from the concentration profile produced as the ethanol vapour diffuses into the airflow. The experiment is set up to measure diffusion from a flat plate and to compare it with the integral solution of the mass transfer equation. Data is presented to show the dependence of the Sherwood number on the Reynolds number.
Challenges and perspectives in MS-based omics approaches for ecotoxicology studies: An insight on Gammarids sentinel amphipods (2023)

The aquatic environment is one of the most complex biosystems, as organism at all trophic levels may be exposed to a multitude of pollutants. As major goals, ecotoxicology typically investigates the impact of toxic pollutants on the ecosystems through the study of sentinel organisms. Over the past decades, Mass Spectrometry (MS)-based omics approaches have been extended to sentinel species both in laboratory and field exposure conditions. Single-omics approaches enable the discovery of biomarkers mirroring the health status of an organism. By covering a restricted set of the molecular cascade, they turn out to only partially satisfy the understanding of complex ecotoxicological effects. In contrast, a more complete understanding of the ecotoxicity pathways can be accessed through multi-omics approaches. In this perspective, we provide a state-of-the-art and a critical evaluation on further developments in MS-based single and multi-omics studies in aquatic ecotoxicology. As case example, literature regarding Gammarids freshwater amphipods, non-model sentinel organisms sensitive to pollutants and environmental changes and crucial species for downstream ecosystems, will be reviewed.
NOBIN-based phosphoramidite and phosphorodiamiditeligands and their use in asymmetric nickel-catalysed hydrovinylation (2012)

Phosphoramidite and P-stereogenic phosphorodiamidite ligands derived from (Sa)-2-phenylamino-2′-hydroxy-1,1′-binaphthyl (N-Ph-NOBIN) and bis(1-phenyl-ethyl)amine were synthesised, fully characterised, and the absolute configuration of the stereogenic phosphorus atoms was assigned. The phosphoramidite ligand L2 features three non-bridged substituents at phosphorus comprising the bis(1-phenylethyl)amine and two NOBIN moieties. The NOBIN units are bound to the phosphorus through the oxygen atoms with two pendant nitrogen atoms. In the Ni-catalysed hydrovinylation of styrene no conversion was observed with the phosphorodiamidites, while the phosphoramidite ligands led to active catalysts with a marked co-operative effect on selectivities. Whereas the racemic product was obtained with the (Sa,Sa,SC,SC) diastereomer, the (Sa,Sa,RC,RC) diastereomer proved to be one of the best ligands for this reaction, leading to almost perfect selectivity and ees of up to 91%.
Performance of transmit beamforming for interference mitigation with random codebooks (2013)

In this paper, we study the interference mitigation capability of Transmit Beamforming (TBF) when used to combat cross-layer interference in a two-tier Heterogeneous Network (Het-Net) scenario. Since generic practical codebook designs are not known when TBF is applied for interference mitigation purposes, a randomly generated codebook is used as a simple way to provide a lower bound performance for any efficient (deterministic) codebook design. Closed-form expressions for the rate performance are derived when altruistic TBF is applied to mitigate interference with different number of transmit antennas and feedback bit resolutions. Our analysis reveals that the use of additional feedback bits has potential to provide more performance gain at lower outage probability regimes (when compared to higher outage probability ones). In addition, for random codebooks with a fixed number of feedback bits, the number of transmit antennas does not have a notable effect on the interference mitigation capability of an altruistic TBF scheme.
Improved Visualization in Difficult-to-Image Stress Echocardiography Patients Using Real-Time Harmonic Spatial Coherence Imaging (2018)

Stress echocardiography is used to detect myocardial ischemia by evaluating cardiovascular function both at rest and at elevated heart rates. Stress echocardiography requires excellent visualization of the left ventricle (LV) throughout the cardiac cycle. However, LV endocardial border visualization is often negatively impacted by high levels of clutter associated with patient obesity, which has risen dramatically worldwide in recent decades. Short-lag spatial coherence (SLSC) imaging has demonstrated reduced clutter in several applications. In this work, a computationally efficient formulation of SLSC was implemented into an object-oriented graphics processing unit-based software beamformer, enabling real-time (>30 frames per second) SLSC echocardiography on a research ultrasound scanner. The system was then used to image 15 difficult-to-image stress echocardiography patients in a comparison study of tissue harmonic imaging (THI) and harmonic spatial coherence imaging (HSCI). Video clips of four standard stress echocardiography views acquired with either THI or HSCI were provided in random shuffled order to three experienced readers. Each reader rated the visibility of 17 LV segments as "invisible," "suboptimally visualized," or "well visualized," with the first two categories indicating a need for contrast agent. In a symmetry test unadjusted for patientwise clustering, HSCI demonstrated a clear superiority over THI ( ). When measured on a per-patient basis, the median total score significantly favored HSCI with . When collapsing the ratings to a two-level scale ("needs contrast" versus "well visualized"), HSCI once again showed an overall superiority over THI, with by McNemar test adjusted for clustering.
Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance (2019)

The discovery of the phosphatidylinositol-3-kinase (PI3K) pathway was a major advance in understanding growth factor signaling. The high frequency of PI3K pathway mutations in many cancers has encouraged a new field targeting cancer driver mutations. Although there have been many successes, targeting PI3K itself has proven challenging, in part because of its multiple isoforms with distinct roles. Despite promising preclinical results, development of PI3K inhibitors as pharmacologic anticancer agents has been limited by modest single-agent efficacy and significant adverse effects. If we could overcome these limitations, PI3K inhibitors would be a powerful cancer-fighting tool. Data from phase III clinical trials yields insight into some of the problems with PI3K inhibitors. Recent advances have shed light on the mechanisms of tumor resistance to PI3K inhibitors via feedback pathways that cause elevated insulin levels that then activate the same PI3K pathways that are the targets of inhibition. Improving our understanding of the complex regulatory feedback pathways that activate in response to PI3K inhibition will reveal ways to increase the efficacy of PI3K inhibitors and reduce adverse effects, increasing the usefulness of this class as a treatment option for multiple cancer types.
mRNA display: Diversity matters during in vitro selection (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
A cognitive QoS management framework for WLANs (2014)

Due to the precipitous growth of wireless networks and the paucity of spectrum, more interference is imposed to the wireless terminals which constraints their performance. In order to preserve such performance degradation, this paper proposes a framework which uses cognitive radio techniques for quality of service (QoS) management of wireless local area networks (LANs). The framework incorporates radio environment maps as input to a cognitive decision engine that steers the network to optimize its QoS parameters such as throughput. A novel experimentally verified heuristic physical model is developed to predict and optimize the throughput of wireless terminals. The framework was applied to realistic stationary and time-variant interference scenarios where an average throughput gain of 344% was achieved in the stationary interference scenario and 70% to 183% was gained in the time-variant interference scenario.
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans (2013)

The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.
THE DIAGNOSTIC VALUE OF THE 128-SLICE SPIRAL CT CORONARY IMAGING AND CORONARY ANGIOGRAPHY IN THE PATIENTS WITH CORONARY HEART (2012)

Objectives To explore clinical diagnostic value of 128-slice spiral CT coronary angiography (128-SCTCA) in the patients with coronary heart disease, and check the population adapt to 128-SCTCA. Methods A retrospective analysis of 198 cases received 128-SCTCA, suspected coronary angiography (CAG) to check the patient's clinical data in the 4 weeks. Duke model in accordance with coronary heart disease concept will be checked into coronary heart disease (n=48 cases) of low-risk, medium risk (n=64 cases) and high-risk (n=86) three group, as ‘standard’ analysis to CAG 128-SCTCA the accuracy of the diagnosis of coronary heart disease and coronary artery calcification in different parts of vascular segments and other factors on the diagnostic accuracy. Results Duke model of coronary artery disease probability low risk group, medium risk group, high-risk group, their coronary artery disease detection rates were 45.4%, 73.6%, 84.2%; 128-SCTCA in diagnosis of coronary heart disease risk group the sensitivity and positive The predictive value was significantly lower than the risk group and high-risk group. Right coronary artery Agatston calcium score &gt;400 grouping, 128-SCTCA diagnostic sensitivity of coronary heart disease (95.6%) was significantly higher than 0–100 grouping and 101 to 400 group (76.3% was 78.7%, p&lt;0.05). 128-SCTCA diagnosis of distal white tube lesion sensitivity, positive predictive value were lower than those near the middle of the white tube (p&lt;0.05). Conclusions 128-SCTCA in Intermediate risk group of DWKE model with coronary heart disease, its diagnostic accuracy was affected by coronary artery calcification, lesion and lumen diameter.
Modeling and fabrication of an RF MEMS variable capacitor with a fractal geometry (2013)

In this paper, we model, fabricate, and measure an electrostatically actuated MEMS variable capacitor that utilizes a fractal geometry and serpentine-like suspension arms. Explicitly, a variable capacitor that possesses a top suspended plate with a specific fractal geometry and also possesses a bottom fixed plate complementary in shape to the top plate has been fabricated in the PolyMUMPS process. An important benefit that was achieved from using the fractal geometry in designing the MEMS variable capacitor is increasing the tuning range of the variable capacitor beyond the typical ratio of 1.5. The modeling was carried out using the commercially available finite element software COMSOL to predict both the tuning range and pull-in voltage. Measurement results show that the tuning range is 2.5 at a maximum actuation voltage of 10V.
Combinatorial Synthesis and Discovery of PEMFC Electrocatalysts on a Scaled Powder Production Platform (2003)

No abstract prepared.
Experimental and Theoretical Demonstration of Wavelength Conversion of 10 Gb/s RZ-OOK in a Si nanowire via XPM (2010)

We present all-optical wavelength conversion (WC) of 10 Gb/s RZ-OOK data in a Si nanowire waveguide via cross-phase-modulation (XPM). The WC mechanism is analytically modeled and shown to be scalable to 40 Gb/s RZ-OOK data.
Vacuum formed bio‐based composite materials using polyolefin and thermally modified wood powder (2022)

Abstract For climate and sustainability reasons, there is an interest and incentive to produce plastic and rubber products with increased content of a bio‐based component, preferably existing as an industrial by‐product, for example, wood powder/sawdust. There are many studies on the making of wood‐plastic composites, but hitherto very few consider vacuum forming as a processing technique, especially considering a biofiller. Here, the properties of a vacuum formed composite with thermally modified wood powder (with reduced water uptake) and a very ductile polyolefin, was reported. Surprisingly, even at a 15 wt% filler content, the composite remained ductile (extensibility of ca. 30%). The water uptake increased with increasing content of wood powder, but was never more than 5%. The water sorption kinetics indicated that the wood powder did not form a percolated continuous path through the material for easy access to the water, which led to a low water diffusivity (ca. 2 × 10 −10 cm 2 s −1 ). The calorimetric data showed that the biofiller, overall, did not affect the melting and crystallization behavior of the polymer matrix, nor the observed glass transition temperature. To conclude, vacuum forming was shown to be a viable technique for composites with a very ductile/elastic matrix and stiff fillers.
AN UNCEMENTED REVISION FEMORAL STEM WITH COMPACTED ALLOGRAFT IS INITIALLY AS STABLE AS AN UNCEMENTED PRIMARY FEMORAL STEM (2002)

Aim: The objective of this study was to compare the initial stability of an uncemented curved long stem femoral component (ABR, Zimmer, Warsaw Indiana) implanted using conventional broaching to an uncemented ABR implanted as a revision using morselized compacted allograft to fill a circumferential proximal bone defect. Materials and Methods: Primary: Eight fresh frozen human femurs were implanted with correctly sized ABR stems without cement using standard surgical instruments and 1mm distal overreaming. The implant was loaded cyclically at 3 hz on a MTS servohdraulic materials test frame in a direction representing the peak force of the stance phase of the gait (2.5 X body weight). A 3-dimensional motion measurement device with six linear variable transformers measure the relative motion between the bone and the prosthesis with an accuracy of 0.5μm. The contruct was loaded in ten cycle increments until the component was seated and then recoverable motion was recorded over a further ten loading cycles. Revision: In the revision case bone loss was modelled by removing all the cancellous bone from the proximal femur with 1mm distal overreaming. Morselized bone graft was impacted into the defect using specially prepared smooth tamps shaped to the geometry of the ABR stem. The original prosthesis was then reimplanted without the use of cement. The seating and testing cycles were repeated. Primary and revision vectors were compared using a paired students t – test. Results: There was no statistically significant difference in the magnitude of the resultant vector of the 3 translational components of the micro motion between the two methods of implantation (p=0.19). Conclusions: Initial stability of a cementless femoral implant is a requirement for bone ingrowth. The use of compacted morsellized allograft in a revision Total Hip Arthroplasty with a proximal circumferential defect can provide a stable bed for the implantation of an uncemented femoral component. The revised implant using the compacted allograft method was initially as stable as the primary implantation. This technique would be particularly applicable when the surgeon would like to avoid the use of cement in a revision setting. The use of this method for uncemented revision Total Hip Arthroplasty should be studied further in a clinical setting before it is advocated for widespread use.
EGF-related peptides are involved in the proliferation and survival of MDA-MB-468 human breast carcinoma cells (1999)

A majority of human breast carcinomas co-express the epidermal growth factor (EGF)-like peptides CRIPTO (CR), amphiregulin (AR) and transforming growth factor alpha (TGF-alpha). MDA-MB-468 breast carcinoma cells express CR, AR and TGFalpha, while SK-BR-3 cells express CR and TGF-alpha. Anti-sense phosphorothioate oligodeoxynucleotides (AS S-oligos) directed against either CR or TGF-alpha inhibit the proliferation of both cell lines. A 40-50% growth inhibition was observed at a 2-microM concentration of each AS S-oligo. Treatment with the AR AS S-oligo also resulted in a significant inhibition of MDA-MB-468 anchorage dependent growth (ADG). No significant growth inhibition was observed when MDA-MB-468 or SK-BR-3 cells were treated with a mis-sense S-oligo. The AS S-oligos inhibited the expression of AR, CR or TGF-alpha proteins and mRNAs, as assessed by immuno-cytochemistry and semi-quantitative RT-PCR. An additive growth-inhibitory effect was observed when MDA-MB-468 cells were treated with a combination of EGF-related AS S-oligos. Indeed, treatment of MDA-MB-468 cells with a combination of AR, CR and TGF-alpha AS S-oligos resulted in about 70% growth inhibition at a concentration of 0.7 microM each. Finally, treatment of MDA-MB-468 cells with a combination either of the 3 AS S-oligos or of an EGF receptor-blocking antibody (MAb 225) and either CR, AR or TGFalpha AS S-oligos resulted in a significant increase in DNA fragmentation. Our data suggest that the EGF-related peptides are involved in the proliferation and survival of breast carcinoma cells.
Flicker-free 3D shutter glasses by retardnace control of LC cell (2013)

Ambient light inside viewing field of shutter-glasses 3DTV system can cause perceivable flicker due to high brightness of the light source. Omitting front polarizer of shutter glasses can be a solution for improving ambient light flicker, but it makes noticeable ghosting whenever 3D viewers tilt their heads. In this paper, we propose the new flicker-free shutter glasses compensated for viewers head tilt using tilt sensor. The crosstalk level, inserted by the shutter is below 1.6% within the tilt angle range from 0 to ±50°.
An 80 mW 40 Gb/s 7-TapT/2-Spaced Feed-Forward Equalizer in 65 nm CMOS (2010)

A 7-tap 40 Gb/s FFE using a 65 nm standard CMOS process is described. A number of broadbanding and calibration techniques are used, which allow high-speed operation while consuming 80 mW from a 1 V supply. ESD protection is added to 40 Gb/s IOs and an inexpensive plastic package is used to make the chip closer to a commercial product. The measured tap delay frequency response variation is less than 1 dB up to 20 GHz and tap-to-tap delay variation is less than 0.3 ps. More than 50% vertical and 70% horizontal eye opening from a closed input eye are observed. The use of a CMOS process enables further integration of this core into a DFE equalizer or a CDR/Demux based receiver.