gebhart/patrepeval huggingface dataset:
General synthesis and metal complexes of fused-ring bicyclic cyclopentadienes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral synthesis and metal complexes of fused-ring bicyclic cyclopentadienesWolfgang A. Herrmann, Reiner Anwander, Herbert Riepl, Wolfgang Scherer, and Claire R. WhitakerCite this: Organometallics 1993, 12, 11, 4342–4349Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/om00035a020https://doi.org/10.1021/om00035a020research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Direct observation of interfacial C60cluster formation in polystyrene–C60nanocomposite films (2009)

Large interfacial C(60) clusters were directly imaged at the supporting film-substrate interface in physically detached polystyrene-C(60) nanocomposite films by atomic force microscopy, confirming the stabilizing mechanism previously hypothesized for thin polymer films. Additionally, we found that the C(60) additive influences basic thermodynamic film properties such as the interfacial energy and the film thermal expansion coefficient.
Studies on MHD pressure drop and heat transfer of helium-lithium annular-mist flow in a transverse magnetic field. (1987)

Pressure drop and heat transfer coefficient of helium-lithium annular-mist flow in a rectangular duct were investigated experimentally under a transverse magnetic field at system pressure of 0.2 MPa. A ratio of MHD pressure drop to that of non-magnetic field increases with magnetic flux density and a mass flow rate ratio of lithium to helium in low helium velocity region. However, as increasing the helium velocity, the increment of MHD pressure drop with the magnetic flux density is much reduced and then becomes almost zero. At this condition, the MHD pressure drop of the annular-mist flow becomes much smaller than that of lithium single phase flow with the same lithium mass flow at the high magnetic flux density. Heat transfer coefficient ratio of the helium-lithium annular-mist flow to helium single phase in the non-magnetic field is well correlated by a ratio of the mass flow rate of lithium to helium. The heat transfer coefficient in the magnetic field increases with the magnetic flux density and then terminates at a certain value depending on the mass flow rate ratio and the helium velocity. These characteristics of the MHD pressure drop and the heat transfer in the magnetic field suggest that the helium-lithium annular-mist flow is effectively applicable to cooling of the high heat flux wall in a strong magnetic field like a first wall of a magnetic confinement fusion reactors.
A Randomized Crossover Trial of Dietary Sodium Restriction in Stage 3–4 CKD (2017)

In this randomized crossover trial, implementation of SRD in patients with CKD stage 3-4 resulted in clinically and statistically significant improvement in BP and hydration status. This simple dietary intervention merits a larger trial in CKD to evaluate effects on major clinical outcomes.
Antigenicity of the Major Polypeptides of Hepatitis B Surface Antigen (HBsAg) (1978)

The major polypeptides (P-1, P-2, and P-6) of HBsAg were isolated from purified preparations of 22-nm HBsAg particles, iodinated, and analyzed by double-antibody radioimmunoprecipitation assays for the presence of hepatitis B virus (HBV)-specific antigens. Each polypeptide fraction contained both group (a) and subtype (d) specific determinants in common by virtue of their immunoreaction with antiserum to native HBsAg and antisera to the other structural polypeptides. The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome.
Cannabinoid Receptor Interacting Protein (CRIP1a) affects CB1 signaling (2008)

Cannabinoid receptor interacting protein 1a (CRIP 1a ) binds to the last nine amino acids of the cannabinoid (CB 1 ) receptor. Receptor binding studies using human embryonic kidney cells transfected with the CB 1 receptor (CB 1 ‐HEK) found that co‐transfection of these cells with CRIP 1a (CB 1 ‐HEK‐CRIP 1a ) did not affect CB 1 receptor expression. [ 35 S]GTPγ S binding studies examined the efficacy of various agonists to activate G‐proteins in CB 1 ‐HEK cells with and without CRIP 1a transfection. CRIP 1a decreased maximal agonist efficacy (E max ) values for the cannabinoids WIN 55,212‐2 (WIN) and CP 55,940 (CP). E max values for methananamide, levonantradol, and Δ 9 ‐tetrahydrocanabinol (THC) were unaffected. Inhibition of basal CB 1 receptor activity by the inverse agonist SR141716A (SR1) was significantly decreased in the presence of CRIP 1a . EC 50 values of all ligands tested were unaffected. Effects of CRIP 1a on CB 1 receptor downregulation was examined by incubating CB 1 ‐HEK cells (±CRIP 1a co‐transfection) with various cannabinoids and measuring receptor levels via [ 3 H]SR1 saturation binding. CRIP 1a inhibited THC‐induced downregulation, but not WIN‐induced downregulation. Downstream signaling studies found no effect of CRIP 1a on modulation of adenyly cyclase or MAP kinase activity by maximally‐effective agonist concentrations. A trend toward a decrease in the inverse agonist effects of SR1 was observed. These results suggest that CRIP 1a modulates CB 1 signaling during acute receptor activation and modulates CB 1 receptor downregulation in a ligand‐specific manner. (Funding: NIH, NIDA grant DA‐05274)
Contact resistivity reduction on lowly-doped n-type Si using a low work function metal and a thin TiOX interfacial layer for doping-free Si solar cells (2017)

Eliminating a doping process could be an effective way to reduce the production cost of c-Si cells. However, in absence of highly doped Si, the formation of a high quality contact is not straightforward. The lack of field-effect passivation from a lowly doped region can lead to a high recombination current density at the contacts (J(0,metal)) and moreover, contact resistivity (rho(c)) typically increases when doping level is decreasing. In this work we focus on reducing the contact resistivity of an electron-selective contact for doping-free cells. Although the effect of low work function metals (LWMs) in combination with an i-a-Si:H layer has already been reported, the synergy effect of a LWM and a MIS (Metal-Insulator-Semiconductor) contact structure on top of the ia-Si:H has not been reported yet. Here, we demonstrate a new ATOM (i-a-Si:H / TiOX / low workfunction metal) contact structure as an electron-selective contact using an i-a-Si:H layer, a TiOX interfacial layer and Ca (Phi 2.9eV) without requiring an additional n(+) doping process. The addition of TiOX in between the i-a-Si:H layer and the Ca decreases the pc by about 2 orders of magnitude. Despite of increased J(0,metal) due to e-beam processing of TiOX, the Ca based ATOM contact increases the potential max efficiency up to 25 %. To the best of our knowledge, this is the first demonstration of an electron-selective contact comprising a low work function metal, an interfacial TiOX and an i-a-Si:H passivation layer. This type of contact could be a promising route for the optimization of doping-free cells (C) 2017 The Authors. Published by Elsevier Ltd.
1.3 μm InAsyP1−y/InP strained-layer quantum well laser diodes grown by metalorganic chemical vapor deposition (1992)

We report on the metalorganic chemical vapor deposition (MOCVD) growth of InAsyPl1−y/InP strained layer quantum wells and the successful lasing of novel InAsyP1−y/InP strained layer quantum well laser diodes at 1.3 μm for the first time. Full width at half maximum of room temperature photoluminescence was as narrow as 30.1 meV with a peak wavelength of 1.29 μm. A very low threshold current density of 0.45 kA/cm2 was obtained on broad contact lasers with a cavity length of 900 μm.
ChemInform Abstract: Structure—Relaxivity Relationships Among Targeted MR Contrast Agents (2012)

Abstract Review: 50 refs.
A Probability Bound Estimation Method in Markov Reliability Analysis (1985)

In many practical systems, the uncertainty of component failure/repair rates results in uncertainty of system failure probability. Concerning a repairable system, uncertainty is evaluated as a probability bound in the Markov process. In practical analysis, the Laplace transform has the advantage of relatively less computing time than that of a numerical method, eg, Runge Kutta. This paper proposes an algorithm for evaluating this uncertainty using the Laplace transform method. This algorithm assumes the Johnson SB distribution for system-failure próbability. Then, the mean and the variance of system-failure probability are obtained using Newton's method and an integral form for calculating parametric differentiation. Finally, the probability bounds are obtained by applying the conventional moment-matching method. A tutorial example is presented at the end of this paper.
Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines. (1993)

Tumor production of a parathyroid hormone-related peptide (PTHrP) is a common cause of the syndrome of humoral hypercalcemia of malignancy, which is frequently associated with renal cell carcinomas. Why certain renal cell carcinomas produce PTHrP while others do not is unknown. Using a system of 12 human renal carcinoma cell lines which either do (n = 6) or do not (n = 6) produce PTHrP, we found that the expression of the PTHrP gene in these cell lines is controlled at the transcriptional level. Transfection studies failed to demonstrate variation in PTHrP promoter activity in these cell lines sufficient to account for the differential PTHrP expression, implicating a cis-acting mechanism. Transcription of the PTHrP gene in these cell lines was found to correlate with the methylation state of specific CpG dinucleotides located within the promoter region but outside a CpG island. The functional importance of this mechanism of control was confirmed by the ability of the demethylating agent, 5-azacytidine, to induce PTHrP mRNA expression in previously nonexpressing cell lines.
Extended Anomalous Foreground Emission in theWMAPThree‐Year Data (2008)

We study the spectral and morphological characteristics of the diffuse Galactic emission in the WMAP temperature data using a template-based multilinear regression, and obtain the following results. (1) We confirm previous observations of a bump in the dust-correlated spectrum, consistent with the Draine &amp; Lazarian spinning dust model. (2) We also confirm the "haze" signal in the inner Galaxy, and argue that it does not follow a free-free spectrum as first thought, but instead is synchrotron emission from a hard electron cosmic-ray population. (3) In a departure from previous work, we allow the spectrum of Hα-correlated emission (which is used to trace the free-free component) to float in the fit, and find that it does not follow the expected free-free spectrum. Instead there is a bump near 50 GHz, modifying the spectrum at the 20% level, which we speculate is caused by spinning dust in the warm ionized medium. (4) The derived cross-correlation spectra are not sensitive to the map zero points, but are sensitive to the choice of CMB estimator. In cases where the CMB estimator is derived by minimizing variance of a linear combination of the WMAP bands, we show that a bias proportional to the cross-correlation of each template and the true CMB is always present. This bias can be larger than any of the foreground signals in some bands. (5) Lastly, we consider the frequency coverage and sensitivity of the Planck mission, and suggest linear combination coefficients for the CMB template that will reduce both the statistical and systematic uncertainty in the synchrotron and haze spectra by more than an order of magnitude.
Where is time spent in message-passing and shared-memory programs? (1994)

Message passing and shared memory are two techniques parallel programs use for coordination and communication. This paper studies the strengths and weaknesses of these two mechanisms by comparing equivalent, well-written message-passing and shared-memory programs running on similar hardware. To ensure that our measurements are comparable, we produced two carefully tuned versions of each program and measured them on closely-related simulators of a message-passing and a shared-memory machine, both of which are based on same underlying hardware assumptions.
High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals (2016)

Heavy metal ions released into the environment from industrial processes lead to various health hazards. We propose an on-chip label-free detection approach that allows high-sensitivity and high-throughput detection of heavy metals. The sensing device consists of 2-dimensional photonic crystal microcavities that are combined by multimode interferometer to form a sensor array. We experimentally demonstrate the detection of cadmium-chelate conjugate with concentration as low as 5 parts-per-billion (ppb).
Controlling Single Molecule Conductance by a Locally Induced Chemical Reaction on Individual Thiophene Units (2020)

Abstract Among the prerequisites for the progress of single‐molecule‐based electronic devices are a better understanding of the electronic properties at the individual molecular level and the development of methods to tune the charge transport through molecular junctions. Scanning tunneling microscopy (STM) is an ideal tool not only for the characterization, but also for the manipulation of single atoms and molecules on surfaces. The conductance through a single molecule can be measured by contacting the molecule with atomic precision and forming a molecular bridge between the metallic STM tip electrode and the metallic surface electrode. The parameters affecting the conductance are mainly related to their electronic structure and to the coupling to the metallic electrodes. Here, the experimental and theoretical analyses are focused on single tetracenothiophene molecules and demonstrate that an in situ‐induced direct desulfurization reaction of the thiophene moiety strongly improves the molecular anchoring by forming covalent bonds between molecular carbon and copper surface atoms. This bond formation leads to an increase of the conductance by about 50 % compared to the initial state.
Electron diffusion in metals studied by picosecond ultrasonics (1994)

We have studied the ultrasonic pulses that are generated when a picosecond light pulse is absorbed in a metallic film. The pulse shape is influenced by the distance that the hot electrons diffuse before losing their energy to the lattice. We show that this method can be used to test theories of the electron-phonon and electron-electron scattering rates. The results are in excellent agreement with a calculation in which the nonthermal character of the electron distribution is taken into account.
On-line calibration of multiple LIDARs on a mobile vehicle platform (2010)

In this paper, we examine the problem of extrinsic calibration of multiple LIDARs on a mobile vehicle platform. To achieve fully automated and on-line calibration, the original non-linear calibration model is reformulated as a second-order cone program (SOCP). This provides an advantage over more standard linearized approaches in that a priori information such as a default LIDAR calibration, calibration tolerances, etc., can be readily modeled. Furthermore, in contrast to general non-linear methods, the SOCP relaxation is convex, returns a global minimum, and can be solved very quickly using modern interior point methods (IPM). This enables the calibration to be estimated on-line for multiple LIDARs simultaneously. Experimental results are provided where the approach is used to successfully calibrate a pair of Sick LMS291-S14 LIDARs mounted on a mobile vehicle platform. These showed the SOCP formulation yielded a more accurate reconstruction and was 1-2 orders of magnitude faster than the traditional non-linear least-squares approach.
TrueFISP-MR-Bildgebung zur Bestimmung des Einflusses der Hämodialyse auf myokardiale Funktionsparameter bei Patienten mit terminaler Niereninsuffizienz (2004)

Cardiac MRI is an accurate tool to identify uremic cardiomyopathy in patients with chronic renal failure undergoing HD. LV functional parameters could be monitored reliably.
Handheld probes and galvanometer scanning for optical coherence tomography (2015)

As part of the ongoing effort of the biomedical imaging community to move Optical Coherence Tomography (OCT) systems from the lab to the clinical environment and produce OCT systems appropriate for multiple types of investigations in a medical department, handheld probes equipped with different types of scanners need to be developed. These allow different areas of a patient’s body to be investigated using OCT with the same system and even without changing the patient’s position. This paper reviews first the state of the art regarding OCT handheld probes. Novel probes with a uni-dimensional (1D) galvanometer-based scanner (GS) developed in our groups are presented. Their advantages and limitations are discussed. Aspects regarding the use of galvoscanners with regard to Micro-Electro- Mechanical Systems (MEMS) are pointed out, in relationship with our studies on optimal scanning functions of galvanometer devices in OCT. These scanning functions are briefly discussed with regard to their main parameters: profile, theoretical duty cycle, scan frequency, and scan amplitude. The optical design of the galvoscanner and refractive optics combination in the probe head, optimized for various applications, is considered. Perspectives of the field are pointed out in the final part of the paper.
Immunotherapeutic approaches to ovarian cancer treatment (2015)

Despite advances in combinatorial chemotherapy regimens and the advent of intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer patients are inadequate. Immunotherapy offers a novel and promising therapeutic strategy for treating ovarian tumors. Following the demonstration of the immunogenicity of ovarian tumors, multiple immunotherapeutic modalities have been developed. Antibody-based therapies, immune checkpoint blockade, cancer vaccines, and chimeric antigen receptor-modified T cells have demonstrated preclinical success and entered clinical testing. In this review, we discuss these promising immunotherapeutic approaches and emphasize the importance of combinatorial treatment strategies and biomarker discovery.
MRPC: A high performance RPC system for MPMD parallel computing (1999)

MRPC is an RPC system that is designed and optimized for MPMD parallel computing. Existing systems based on standard RPC incur an unnecessarily high cost when used on high-performance multi-computers, limiting the appeal of RPC-based languages in the parallel computing community. MRPC combines the efficient control and data transfer provided by Active Messages (AM) with a minimal multithreaded runtime system that extends AM with the features required to support MPMD. This approach introduces only the necessary RPC overheads for an MPMD environment. MRPC has been integrated into Compositional C++ (CC++), a parallel extension of C++ that offers an MPMD programming model. Basic performance in MRPC is within a factor of two from those of Split-C, a highly tuned SPMD language, and other messaging layers. CC++ applications perform within a factor of two to six from comparable Split-C versions, which represent an order of magnitude improvement over previous CC++ implementations. Copyright © 1999 John Wiley & Sons, Ltd.
Synesthesia for manual alphabet letters and numeral signs in second-language users of signed languages (2016)

Many synesthetes experience colors when viewing letters or digits. We document, for the first time, an analogous phenomenon among users of signed languages who showed color synesthesia for fingerspelled letters and signed numerals. Four synesthetes experienced colors when they viewed manual letters and numerals (in two cases, colors were subjectively projected on to the hands). There was a correspondence between the colors experienced for written graphemes and their manual counterparts, suggesting that the development of these two types of synesthesia is interdependent despite the fact that these systems are superficially distinct and rely on different perceptual recognition mechanisms in the brain.
Assessment of Histologic Disease Activity in Crohnʼs Disease (2014)

Measurement of histologic disease activity has potential value in CD; however, no validated measures are available. Additional research is needed to develop a methodologically rigorous instrument for use in clinical investigation and potentially for clinical practice.
A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder (2021)

Genes that are primarily expressed in cochlear glia-like supporting cells (GLSs) have not been clearly associated with progressive deafness. Herein, we present a deafness locus mapped to chromosome 3p25.1 and an auditory neuropathy spectrum disorder (ANSD) gene, <i>TMEM43</i>, mainly expressed in GLSs. We identify p.(Arg372Ter) of <i>TMEM43</i> by linkage analysis and exome sequencing in two large Asian families segregating ANSD, which is characterized by inability to discriminate speech despite preserved sensitivity to sound. The knock-in mouse with the p.(Arg372Ter) variant recapitulates a progressive hearing loss with histological abnormalities in GLSs. Mechanistically, TMEM43 interacts with the Connexin26 and Connexin30 gap junction channels, disrupting the passive conductance current in GLSs in a dominant-negative fashion when the p.(Arg372Ter) variant is introduced. Based on these mechanistic insights, cochlear implant was performed on three subjects, and speech discrimination was successfully restored. Our study highlights a pathological role of cochlear GLSs by identifying a deafness gene and its causal relationship with ANSD.
ChemInform Abstract: On Stereochemistry of Osmium Tetroxide Oxidation of Allylic Alcohol Systems: Empirical Rule. On Stereochemistry of Osmium Tetroxide Oxidation of Allylic Alcohol Systems: Examples. (1984)

Abstract Die Oxidation von Olefinen zu Diolen in Gegenwart von Osmiumtetroxid wird systematisch untersucht.