gebhart/patrepeval huggingface dataset:
O2‐13‐03: Efficacy of ACI‐35, A Liposomal Anti‐Phospho Tau Vaccine in Two Different Mouse Models of Alzheimer's Disease (2016)

The objective of this study was to determine the efficacy of ACI-35, a liposomal anti-phospho-Tau vaccine in two different mouse models of Alzheimer's Disease. A transgenic model where a clinical mutant form of human Tau (P301S) is expressed under the control of the murine neuron-specific Thy1 promoter and a Tau spreading model where tauopathy is initiated by adeno- associated virus (AAV)–mediated delivery of the human Tau protein carrying the P301S mutation (AAV-TauP301S) were used. The hTauP301S-Tg model used in this study is characterized by an early onset of Tau pathology in the brain and spinal cord, starting at the age of three months. Six weeks old hTauP301S transgenic mice were immunized 6 times with ACI-35 or PBS for a period of four months. C57BL/6 P3 neonate mice were intracerebroventricularly injected with AAV-TauP301S or a control vector. This model leads to rapid accumulation of pathologic Tau species in all cortical regions, which mainly leads to impairments in mouse motor behavior. At the age of six weeks, mice were 4 times immunized with ACI-35 for a period of two months. The IgG antibody responses were evaluated in plasma. Different brain fractions were used to evaluate the levels of Tau species by Western Blot or AlphaLISA and the behavior was assessed by rotarod in both models. ACI-35 induced high and phospho Tau-specific antibody titers in both tauopathy models. In the hTauP301S-Tg model, Western Blot analysis by HT7, AD2 and AT100 antibodies demonstrated a decrease of insoluble Tau by ACI-35 treatment. In the AAV-Tau P301S model, AlphaLISA measurements demonstrated a significant decrease of human Tau multimers (HT7/HT7 setup), as well as a significant decrease of a misfolded Tau (MC-1/HT7 setup) in a total brain fraction. A trend to decrease human Tau phosphorylated at pS396 in different brain fractions was also observed. ACI-35 treatment significantly improved the rotarod performance in both the transgenic hTauP301S-Tg model and the AAV-TauP301S spreading model. The study demonstrated that active immunization with ACI-35 significantly decreased human pathological Tau species in different brain fractions and ameliorated the clinical phenotype in two different mouse models of tauopathy.
Direct observation of nitrogen monofluoride(x) using laser-induced fluorescence: kinetics of the (nitrogen monofluoride)3.SIGMA.- ground state (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect observation of nitrogen monofluoride(x) using laser-induced fluorescence: kinetics of the (nitrogen monofluoride)3.SIGMA.- ground stateR. F. Heidner III, Henry Helvajian, J. S. Holloway, and J. Brooke KoffendCite this: J. Phys. Chem. 1989, 93, 23, 7813–7818Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/j100360a018https://doi.org/10.1021/j100360a018research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
WAVN: Wide Area Visual Navigation for Large-scale, GPS-denied Environments (2023)

This paper introduces a novel approach to GPS-denied visual navigation of a robot team over a wide (i.e., out of line of sight) area which we call WAVN (Wide Area Visual Navigation). Application domains include small-scale precision agriculture as well as exploration and surveillance. The proposed approach requires no exploration or map generation, merging, and updating, some of the most computationally intensive aspects of multi-robot navigation, especially in dynamic environments and for long-term deployments. In contrast, we extend the visual homing paradigm to leverage visual information from the entire team to allow a robot to home to a distant location. Since it only employs the latest imagery, the approach can be resilient to the current state of the environment. WAVN requires three components: identification of common landmarks between robots, a communication infrastructure, and an algorithm to find a sequence of common landmarks to navigate to a goal. The principal contribution of this paper is the navigation algorithm in addition to simulation and physical robot results characterizing performance. The approach is also compared to more traditional map-based approaches.
A 100Gbps Interface for 4k/8k UHDTV Signals (2016)

A *100Gbps Real Time Interface” has been developed specifically to transmit 4k and 8k UHDTV image formats. This 100Gbps interface can carry 8k/50P-60P/4:4:4/12bit or 8k/100P120P/4:2:2/10bit image formats. The DC balance and clock recovery was secured by adopting the 8b/10b coding. A transmission distance of 2km the same as those of the HD/3G-SDI optical interfaces was achieved by adopting the 1.3um QSFP28 optical module. The QSFP optical module has evolved and treats the data as 4x28Gbps. This 100Gbps Interface can be the next generation Real Time Interface that can cover all the 4k and 8k signal formats defined by SMPTE ST 2048-1 and SMPTE ST 2036-1 as well as SMPTE ST 274 and SMPTE ST 296. It also maintains backward compatibility because its I/O supports HD/3G-SDI.
Axially asymmetric metal alkyls. Part 6. Lithiation of 2,2′-dimethyl-1,1′-binaphthyl and its trimethylsilylated compounds, and of 2,2′,6,6′-tetramethyl-1,1′-biphenyl (asymmetric induction): X-ray crystal structures of monomeric [{Li(Me2NCH2CH2NMe2)}2{(2-CH2C10H6)2}] and [Li{(Me2NCH2CH2)2NMe}{2-CH2-6-Me(C6H3)2-2′,6′-Me2}] (1988)

The compound [{Li(tmen)}2{(2-CH2C10H6)2}], (6)(tmen =N,N,N′,N′-tetramethylenediamine), has been prepared via metallation, and structurally characterized using X-ray diffraction data. It is monomeric with two different lithium centres, one bridging the ipso-carbon atoms at 2.13(5) and 2.23(5)Å, the other interacting with one ipso-carbon at 2.36(5)Å and its adjacent ring carbon at 2.51(5)Å, such that one ipso carbon is bridging the lithium centres. 7Li N.m.r. data are consistent with this structure in toluene, below ca.–28 °C. Treatment of (6) with AsMe2I then Mel yielded the arsonium salt [(2-Me3AsCH2C10H6)2]I2, and with SiMe3Cl it gave (2-Me3SiCH2C10H6)2. This afforded [2-(Me3Si)2CHC10H6]2 on treatment with LiBun(tmen) then SiMe3Cl. Metallation of 2,2′,6,6′-Tetramethyl-1,1′-biphenyl using LiBun(pmdien)(pmdien =N,N,N′,N′,N″-pentamethyldiethylenetriamine) in diethyl ether yielded a monolithiated species [{Li(pmdien)}{2-CH2-6-Me(C6H3)2-2′,6′-Me2}](13), also structurally characterized; the lithium centre is attached to only the ipso-carbon of the hydrocarbyl group at 2.14(2)Å. Treatment of the same biphenyl with LiBun(sp)[sp =(–)sparteine] in Et2O yielded a dilithiated species based on the asymmetrical chiral dianion, (2-CH2-6-MeC6H3)22–. The degree of asymmetric induction in the metallation step was estimated to be ca. 40% using a 1H n.m.r.–chiral lanthanide shift reagent technique on the diol (2-HOCH2CH2-6-MeC6H3)2, formed by carboxylation then esterification and reduction of the dilithiated species.
Aero Engine Concepts Beyond 2030: Part 2 — The Free-Piston Composite Cycle Engine (2020)

Abstract Recognizing the attention currently devoted to the environmental impact of aviation, this three-part publication series introduces two new aircraft propulsion concepts for the timeframe beyond 2030. Part one focuses on the steam injecting and recovering aero engine concept. This second part presents the free-piston composite cycle engine concept. A third publication, building upon those two concepts, presents the project which aims for demonstrating the proof of concept with numerical simulation and test-bench experiments up to a technology readiness level of three. The free-piston composite cycle engine concept is composed of a gas turbine topped with a free-piston system. The latter is a self-powered gas generator in which the internal combustion process drives an integrated air compressor. Here, several free-piston engines replace the high-pressure core of the gas turbine. Through the ability to work at much higher temperatures and pressures, the overall system efficiency can be increased significantly, and fuel burn as well as CO2 emissions reduce. The proposed free-piston composite cycle engine design is described in detail, and the sources of thermodynamic benefits are stated. Concrete engineering solutions consider the implementation into an aircraft. The free-piston design enables lower weight and size compared to a crankshaft-bound piston engine, as no mechanical transmission and lubrication system is required. The absence of a crankshaft and connecting rods eliminates reactive forces, reduces mechanical losses, and allows higher mean piston velocities. Facilitated through air lubrication, higher cylinder temperatures are viable. The reduction of heat losses enables cooling of the piston-cylinder with core fluid. The use of a sequential combustion chamber can enhance operability and tailor the production of NOx in low-altitude operation. A discussion of emissions affecting the environment shows the potential to reduce the climate impact of aviation.
Use of spray-cooling technology for development of microencapsulated capsicum oleoresin for the growing pig as an alternative to in-feed antibiotics: A study of release using in vitro models1 (2007)

The aim of this study was to develop sustained release microspheres of capsicum oleoresin as an alternative to in-feed additives. Two spray-cooling technologies, a fluidized air bed using a spray nozzle system and a vibrating nozzle system placed on top of a cooling tower, were used to microencapsulate 20% of capsicum oleoresin in a hydrogenated, rapeseed oil matrix. Microencapsulation was intended to reduce the irritating effect of capsicum oleoresin and to control its release kinetics during consumption by the animal. Particles produced by the fluidized air bed process (batch F1) ranged from 180 to 1,000 microm in size. The impact of particle size on release of capsaicin, the main active compound of capsicum oleoresin, was studied after sieving batch F1 to obtain 4 formulations: F1a (180 to 250 microm), F1b (250 to 500 microm), F1c (500 to 710 microm), and F1d (710 to 1,000 microm). The vibrating nozzle system can produce a monodispersive particle size distribution. In this study, particles of 500 to 710 microm were made (batch F2). The release kinetics of the formulations was estimated in a flow-through cell dissolution apparatus (CFC). The time to achieve a 90% dissolution value (T90%) of capsaicin for subbatches of F1 increased with the increase in particle size (P < 0.05), with the greatest value of 165.5 +/- 13.2 min for F1d. The kinetics of dissolution of F2 was slower than all F1 subbatches, with a T90% of 422.7 +/- 30.0 min. Nevertheless, because CFC systems are ill suited for experiments with solid feed and thus limit their predictive values, follow-up studies were performed on F1c and F2 using an in vitro dynamic model that simulated more closely the digestive environment. For both formulations a lower quantity of capsaicin dialyzed was recorded under fed condition vs. fasting condition with 46.9% +/- 1.0 vs. 74.7% +/- 2.7 for F1c and 32.4% +/- 1.4 vs. 44.2% +/- 2.6 for F2, respectively. This suggests a possible interaction between capsaicin and the feed matrix. Moreover, 40.4 +/- 3.9% of the total capsaicin intake in F2 form was dialyzed after 8 h of digestion when feed had been granulated vs. 32.4 +/- 1.4% when feed had not been granulated, which suggests that the feed granulation process could lead to a partial degradation of the microspheres and to a limitation of the sustained release effect. This study demonstrates the potential and the limitations of spray-cooling technology to encapsulate feed additives.
Whole-genome sequencing identifies variants in ANK1 , LRRN1 , HAS1, and other genes and regulatory regions for stroke in type 1 diabetes (2022)

Abstract Aims Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, with distinct clinical and neuroimaging characteristics as compared to those without diabetes. Using whole-genome sequencing (WGS) and whole-exome sequencing (WES), we aimed to find rare and low-frequency genomic variants associated with stroke in T1D. The lead findings were followed up in various datasets to replicate the findings and to assess their specificity to diabetes. Methods and Results We studied stroke genetics in 1,051 individuals with T1D using WGS or WES. We analysed the genome with single-variant analyses, gene aggregate analyses, and aggregate analyses on genomic windows, enhancers and promoters. Furthermore, we attempted replication in T1D using a genome-wide association study (N=3,945) and direct genotyping (N=3,600), and in the general population from the FinnGen project and UK Biobank summary statistics. We identified a rare missense mutation on SREBF1 associated with hemorrhagic stroke (rs114001633, p.Pro227Leu, p -value=8.96×10 -9 ), which further replicated in T1D. Using gene aggregate analysis with protein altering or protein truncating variants, we identified exome-wide significant genes: ANK1 and LRRN1 displayed replication evidence in T1D, while LRRN1 , HAS1 and UACA replicated in the general population (UK Biobank). Furthermore, we performed sliding-window analyses and identified 14 genome-wide significant windows for stroke on 4q33-34.1, of which two replicated in T1D, and a suggestive genomic window on LINC01500 , which replicated in T1D. Finally, with the regulatory region aggregate analyses, we identified a stroke-associated TRPM2-AS promoter ( p -value=5.78×10 -6 ), which we validated with an in vitro cell-based assay. TRPM2 has been previously linked to ischemic stroke. Conclusions Here, we report the first genome-wide analysis on stroke in individuals with diabetes. We identified multiple stroke risk loci with evidence of replication: 4q33-34.1, SREBF1 , and ANK1 for stroke in T1D; and HAS1 , UACA , LRRN1 , LINC01500 , and TRPM2-AS promoter for stroke potentially generalizable to the non-diabetic population.
Synthesis of Imidazolo-Piperidinopentoses as Nagstatine Analogues (2001)

The syntheses of the four imidazolo-piperidino-pentoses 3−6, which belong to the D-series, and of their L-enantiomers, ent-3 to ent-6, are reported. Ascorbic acid and isoascorbic acid were converted over several steps into the L-threo/L-erythro- and the D-erythro/D-threo-configured aldotetroses, respectively, which are the key building blocks for the eight target imidazolo-pentoses cited above. Nucleophilic addition of a metallated imidazole to any one of these four aldotetroses gave the corresponding two diastereomeric adducts, intramolecular cyclisation of which provided the expected bicyclic target molecules, with some protection and deprotection steps being unavoidable prerequisites. The structures and configurations of all eight piperidinoses in Scheme 1 were determined unambiguously, by a combination of 1H/13C NMR spectroscopy, circular dichroism (CD) and [α]D values, in conjunction with single-crystal X-ray diffraction analyses of the L-arabino and D-lyxo azasugars ent-3 and 6. Although lacking the hydroxymethylene group in the C(5) position, the overall structure of these eight stereomers strongly resembles that of the natural product nagstatine (1), a potent inhibitor of N-acetyl-β-D-glucosaminidase. As a matter of fact, after examination of the inhibitory properties of these imidazolo-piperidinoses against six commonly encountered glycosidases, we observe that the L-arabino imidazolo-sugar ent-3 is a potent inhibitor in this series, with Ki = 1 μM both with a β-glucosidase and with a β-galactosidase. The D-ribo and D-xylo stereomers 4 and 5 proved to be inhibitors of a β-glucosidase of similar magnitude (4: Ki = 20 μM; 5: Ki = 17 μM), the other stereomers being either modest to poor inhibitors, or showing no inhibition at all.
Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data (2016)

Preterm birth is commonly defined as any birth before 37 weeks completed weeks of gestation. An estimated 15 million infants are born preterm globally, disproportionately affecting low and middle income countries (LMIC). It contributes directly to estimated one million neonatal deaths annually and is a significant contributor to childhood morbidity. However, in many clinical settings, the information available to calculate completed weeks of gestation varies widely. Accurate dating of the last menstrual period (LMP), as well as access to clinical and ultrasonographic evaluation are important components of gestational age assessment antenatally. This case definition assign levels of confidence to categorisation of births as preterm, utilising assessment modalities which may be available across different settings. These are designed to enable systematic safety evaluation of vaccine clinical trials and post-implementation programmes of immunisations in pregnancy.
Solid-State Li-Ion Batteries Using Fast, Stable, Glassy Nanocomposite Electrolytes for Good Safety and Long Cycle-Life (2016)

The development of safe, stable, and long-life Li-ion batteries is being intensively pursued to enable the electrification of transportation and intelligent grid applications. Here, we report a new solid-state Li-ion battery technology, using a solid nanocomposite electrolyte composed of porous silica matrices with in situ immobilizing Li(+)-conducting ionic liquid, anode material of MCMB, and cathode material of LiCoO2, LiNi1/3Co1/3Mn1/3O2, or LiFePO4. An injection printing method is used for the electrode/electrolyte preparation. Solid nanocomposite electrolytes exhibit superior performance to the conventional organic electrolytes with regard to safety and cycle-life. They also have a transparent glassy structure with high ionic conductivity and good mechanical strength. Solid-state full cells tested with the various cathodes exhibited high specific capacities, long cycling stability, and excellent high temperature performance. This solid-state battery technology will provide new avenues for the rational engineering of advanced Li-ion batteries and other electrochemical devices.
Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure (2006)

The acute reduction in LV volume after CRT is mediated by haemodynamic and geometric benefits without actual changes in LV mass. However, at 3-month follow-up, reduction in LV mass and regional wall thickness was demonstrated, which represents structural reverse remodelling. Such benefit was only observed in volumetric responders but was worsened in non-responders.
Anti-Angiogenic Gene Therapy for Metastatic Renal Cell Carcinoma Produces Tumor Growth Suppression in an Athymic Nude Mouse Model (2007)

Adenoviral vectors expressing endostatin-angiostatin fusion protein have effective anti-angiogenic action against human renal cell carcinoma cells as well as potential as a novel treatment for metastatic renal cell carcinoma.
Confiding in and Listening to Virtual Agents (2017)

We present an intelligent virtual interviewer that engages with a user in a text-based conversation and automatically infers the user's psychological traits, such as personality. We investigate how the personality of a virtual interviewer influences a user's behavior from two perspectives: the user's willingness to confide in, and listen to, a virtual interviewer. We have developed two virtual interviewers with distinct personalities and deployed them in a real-world recruiting event. We present findings from completed interviews with 316 actual job applicants. Notably, users are more willing to confide in and listen to a virtual interviewer with a serious, assertive personality. Moreover, users' personality traits, inferred from their chat text, influence their perception of a virtual interviewer, and their willingness to confide in and listen to a virtual interviewer. Finally, we discuss the implications of our work on building hyper- personalized, intelligent agents based on user traits.
ChemInform Abstract: Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 11. Transformations of Alkali Metal Hydroxides During Vinylation of 1‐Heptanol with Acetylene under Elevated Pressure. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dual-axis pi-pulse spin-exchange relaxation-free magnetometer (2018)

We present a new spin-exchange relaxation-free vector magnetometer with suppressed 1/f probe noise, achieved by applying a small DC bias field and a comb of magnetic DC $π$ pulses along the pump direction. This results in a synchronous orthogonal AC response for each of its two sensitive axes. The new magnetometer is particularly well-suited to applications such as biomagnetism in which the signal to be measured carries a dominant component of its power at low frequencies. The magnetometer reaches a technical noise floor of 8.4 fT/sqrt(Hz) (x) and 11 fT/sqrt(Hz) (y) at 0.01 Hz. A single-axis DC SERF sharing the same experimental apparatus attains 61 fT/sqrt(Hz) at the same frequency. A noise minimum of 1.1 fT/sqrt(Hz) (x) and 2.0 fT/sqrt(Hz) (y) is reached by the new magnetometer at 10 Hz, compared to 0.7 fT/sqrt(Hz) at 25 Hz for a DC SERF.