gebhart/patrepeval huggingface dataset:
Processing and Characterization of TiAl-based Alloys: Towards an Industrial Scale (2011)

This paper highlights Onera efforts focused on the design of new TiAl-based alloys, the development of a commercially-viable route for the manufacture of aero engine components and the optimization of mechanical properties. The alloy G4, with a duplex microstructure, has been developed with an excellent balance of properties for gas turbine applications up to 800°C. Additionally, a series of TiAl-3(Fe,Zr,Mo) alloys have been designed for applications with good ductility requirements. Since these alloys were developed for the casting route, results show that the minimization of subsequent heat treatments is required for property scatter reduction. Alternatively, the Powder Metallurgy (PM) route was explored with the aim of establishing well defined microstructure- property relationships. Moreover, microstructural changes and related phase transformations were fully clarified in the now well known 47-2-2 alloy. This thorough understanding then enabled us to optimize the microstructure of the 47-2-2 alloy via process parameters, in order to meet industrial requirements in terms of tensile, creep, and fatigue properties. Furthermore, in the last three years, alternative PM processing routes, by means of Spark Plasma Sintering and Direct Metal Deposition processes, were found to provide enhanced tensile properties. Finally, structural factors such as the surface-related embrittlement and the formation of oxide scales that occurs on the degradation of mechanical properties, and in turn on the temperature limitations of the TiAl-based alloys, were identified. Different approaches aimed at improving the oxidation/ corrosion resistance are then described to achieve a better environmental durability for TiAl-based alloys.
Vapor-Deposited Glasses Highlight the Role of Density in Photostability (2020)

Photoresponsive molecules can be integrated into glassy materials to probe the local environment and invoke responsive changes in polymer behavior. For example, recent experiments and simulations have studied increased stability in vapor-deposited glasses by examining the photoisomerization rate of a probe molecule. At the theoretical level, past work relied on coarse-grained simulations to explain the role of photoisomerization on glass behavior. In order to effectively exploit these molecular probes, an ability to quantify how the local environment influences the photoisomerization rate is needed. In this work, we present all-atom molecular-dynamics (MD) simulations of molecular glasses of photoresponsive azobenzene (AB) molecules. The stability of these in-silico samples is probed using photoisomerization, where AB molecules can undergo trans → cis transition upon light exposure. Vapor-deposited and bulk-cooled glasses of AB are simulated using a classical dihedral-switching potential developed by Böckmann et al. (<i>J. Phys. Chem. A</i> <b>2010,</b> <i>114,</i> 745-754) to model the photoisomerization process. The MD simulations include thousands of molecules and run for tens of nanoseconds. These size and time scales allow us to explore the broad distribution of photoisomerization wait times, which yields two results. First, the wait-time distributions for both physical vapor deposition and bulk-cooled glasses depend strongly on sample and local density, showing that density or local packing is a primary factor in glass stability against photoisomerization and the experimentally measured photoresponse. Second, the distribution follows a power-law with exponent <i>b</i> ≈ 1.25-1.3 that extends to longer times with increasing density. The power-law distribution suggests a connection with previous experiments that related barriers to photoisomerization with an effective photoisomerization temperature.
Identification and Characterization of a New Intermediate in the Ribosylative Inactivation Pathway of Rifampin by Mycobacterium smegmatis (1999)

Mycobacterium smegmatis DSM 43756 inactivates rifampin by ribosylation. To study this process of rifampicin, all possible inactivated forms of the antibiotic were extracted and purified. Structural studies showed the presence of a new inactivation product, designated RIP-TAp(23-phosphoribosyl-rifampin). Formation of 23-(O-ADP-ribosyl)rifampin (RIP-TAs) is the first step, followed by removal of AMP to give rise to the newly identified compound. Lastly, dephosphorylation leads to formation of 23-ribosyl-rifampin (RIP-Mb). Feeding experiments with the ADP-ribosylated antibiotic obtained from the cell homogenates of an Escherichia coli strain carrying the cloned M. smegmatis gene confirmed this rifampin inactivation process.
A Large Animal Fatal Extremity Hemorrhage Model and Evaluation of a Polymeric Dressing (Fatal Extremity Hemorrhage) (2006)

The physical characteristics of tissue injury, need for anticoagulation, and manipulation of blood pressure are vital factors contributing to the lethality of a large animal fatal extremity hemorrhage model. BioFoam was successful in preventing fatal arterial extremity hemorrhage after the release of an effective tourniquet in some cases. An agent that can reliably allow for safe tourniquet removal and restoration of collateral circulation is a potential solution to tourniquet-associated morbidity in traumatic extremity injury. The model developed will serve as a rigorous test for such agents.
Wotan: A tool for rapid evaluation of FPGA architecture routability without benchmarks (2015)

FPGA routing architectures consist of routing wires and programmable switches which together account for a significant portion of the fabric delay and area. Routing architectures have traditionally been evaluated using a full CAD flow with a suite of benchmark circuits. While the results of such a flow can be accurate, CAD tools are often tuned to a specific architecture type and can take a long time to run which prohibits quick exploration of different architectures early in the design process. In this paper we present an alternative approach that quickly estimates routability for a wide range of architectures without the use of benchmark circuits. Our new routability predictor first assigns congestion probabilities to the architecture's routing resources based on demand estimates found via efficient path enumeration through the routing graph. Next, we compute the probabilities of successfully routing different source/sink connections and finally we combine them to assign an overall routability score. We describe our predictor and present routability estimates for a range of 6-LUT and 4-LUT architectures, showing reasonable agreement with routability results from the full VPR CAD flow in much less CPU time.
Supplementary Table S6 from Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma (2023)

&lt;p&gt;Table S6&lt;/p&gt;
A new 3-D subband video coding technique (2002)

We present in this paper a new 3-D subband coding method with low complexity, high performance, and features that facilitate channel error resilience. Four variations of the coder are discussed: one employing an octave band decomposition: one using the discrete cosine transforms (DCT) and two using lapped transforms. The base coder uses generalized adaptive quantization to code the subbands. Good performance at high compression ratios is obtained without traditional motion compensated prediction. Furthermore, these performance improvements can be realized without the use of entropy coding, which can make the system attractive for operation in error prone environments. Experimental results have shown that the subband video coder and its variations are able to achieve significant performance improvements over MPEG-2.
A Software-Defined Ultrasonic Networking Framework for Wearable Devices (2016)

Wearable medical devices with wireless capabilities have become the cornerstone of many revolutionary digital health applications that promise to predict and treat major diseases by acquiring and processing physiological information. Existing wireless wearable devices are connected through radio frequency electromagnetic wave carriers based on standards, such as Bluetooth or Wi-Fi. However, these solutions tend to almost blindly scale down traditional wireless technologies to the body environment, with little or no attention to the peculiar characteristics of the human body and the severe privacy and security requirements of patients. We contend that this is not the only possible approach, and we introduce U-Wear, the first networking framework for wearable medical devices based on ultrasonic communications. U-Wear encloses a set of physical, data link, and network layer functionalities that can flexibly adapt to application and system requirements to efficiently distribute information between ultrasonic wearable devices. U-Wear also offers reconfiguration functionalities at the application layer to provide a flexible platform to develop medical applications. We design two prototypes that implement U-Wear and operate in the near-ultrasonic frequency range using commercial-off-the-shelf (COTS) speakers and microphones. Despite the limited bandwidth, i.e., about 2 kHz, and COTS hardware components not optimized for operating at high frequency, our prototypes: 1) achieve data rates up to 2.76 kbit/s with bit-error-rate lower than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> using a transmission power of 13 dBm (20 mW ); 2) enable multiple nodes to share the medium; and 3) implement reconfigurable processing to extract medical parameters from sensors with high accuracy.
Long-term treatment of patients with idiopathic pulmonary fibrosis with nintedanib: results from the TOMORROW trial and its open-label extension (2017)

The TOMORROW trial of nintedanib comprised a randomised, placebo-controlled, 52-week period followed by a further blinded treatment period and an open-label extension. We assessed outcomes across these periods in patients randomised to nintedanib 150 mg twice daily or placebo at the start of TOMORROW. The annual rate of decline in FVC was -125.4 mL/year (95% CI -168.1 to -82.7) in the nintedanib group and -189.7 mL/year (95% CI -229.8 to -149.6) in the comparator group. The adverse event profile of nintedanib remained consistent throughout the studies. These results support a benefit of nintedanib on slowing progression of idiopathic pulmonary fibrosis beyond 52 weeks.
Long-Lasting Antifouling Coating from Multi-Armed Polymer (2013)

We describe a new antifouling surface coating, based on aggregation of a short amphiphilic four-armed PEG-dopamine polymer into particles and on surface binding by catechol chemistry. An unbroken and smooth polymeric coating layer with an average thickness of approximately 4 μm was formed on top of titanium oxide surfaces by a single step reaction. Coatings conferred excellent resistance to protein adhesion. Cell attachment was completely prevented for at least eight weeks, although the membranes themselves did not appear to be intrinsically cytotoxic. When linear PEG or four-armed PEG of higher molecular weight were used, the resulting coatings were inferior in thickness and in preventing protein adhesion. This coating method has potential applicability for biomedical devices susceptible to fouling after implantation.
Supplementary Figures 3 and 4 from Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5 (2023)

&lt;p&gt;Figure S3: Characterization of UT-7/Epo, HMC1.1 and HMC1.2 cell lines. Figure S4: 2D1 and 3G1-Fc do not compete with 104D2 mAb binding to KIT.&lt;/p&gt;
QUILT (2019)

A Digital twin is the virtual replica of a physical system. Digital twins are useful because they provide models and data for design, production, operation, diagnostics, and prognostics of machines and products. Traditionally, building a digital twin requires many built-in sensors to monitor various physical phenomena associated with cyber-physical systems such as vibration, energy consumption, etc. However, many legacy manufacturing systems do not have multi-physics sensors built-in by default. Moreover, it might not be feasible to intrusively place sensors in these systems after they are manufactured. To bring the advantages of digitalization to legacy manufacturing systems, this paper contributes with an Internet-of-Things (IoT) based methodology to build digital twins using an indirect medium such as side-channels, which can localize anomalous faults and infer the quality of the products being manufactured while keeping itself up-to-date. We achieve this by exploring and utilizing the side-channels (emissions such as acoustics, power, magnetic, etc.) of the system that unintentionally reveal the cyber and physical state of the system. To validate our methodology, in this paper, we focus on building a digital twin model of a Fused-Deposition Modeling (FDM) based Cartesian additive manufacturing system. The proposed methodology achieves 83.09% accuracy in anomaly localization. To the best of our knowledge, this is the first work demonstrating the possibility of modeling and maintaining a living digital twin of a manufacturing system by extracting information from the side-channels using low-end IoT sensors.
Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: In vitro and in vivo evaluation (2010)

The objective of this study was to evaluate the effect of formulation composition and continuous ultrasound at 1.5 W/Cm² intensity on the permeation of ibuprofen across polymeric and biological barriers. In vitro studies were performed using cellulose membrane and rabbit skin, whereas in vivo studies were performed on rabbits. Overall, higher transport data were obtained with the cellulose membrane. Nonetheless, with both barriers, transport was higher with the gel formulation than oleaginous or emulsion based preparations, which was also dependent on the viscosity of the gel and the concentration of the formulation additives. Transport increased with the increase in alcohol concentration and decreased with the addition of propylene glycol. Ultrasound had a significant effect on ibuprofen transport. For example, an 11-fold increase in drug permeation across cellulose membrane was observed after the application of ultrasound. Similar effect was observed in animal studies. Ibuprofen plasma concentration increased with the concentration of the drug in the gel, which significantly increased after the application of ultrasound. It was concluded that aqueous gel formulations act as ideal coupling agents for topical application of drugs. Nonetheless, in addition to ultrasound, the composition of the gel is expected to have a significant effect on the transdermal delivery of drugs.
Chimie et lumière (2021)

La lumière est partout et la chimie est partout. Mais ces deux entités se rencontrent-elles alors que l'une est immatérielle et l'autre constitutive de tous les objets ? Oui, bien sûr ! Cela s'est d'abord manifesté dans les sources naturelles que sont le soleil, les éclairs ou quelques rares espèces vivantes, puis par le feu dont la domestication a transformé l'existence. Et puis la vie ? Elle n'existerait pas sans lumière par l'intermédiaire de la chimie. Cette situation annonçait une avalanche de révolutions techniques ; elle est encore en cours et continue à bouleverser nos vies, en particulier par les écrans (télévision, téléphones, ordinateurs...), mariages savants de lumière et de chimie ! La première partie de l'ouvrage campe les bases du domaine (photochimie, nouveaux matériaux) puis aborde deux grandes énigmes : l'influence de la lumière du jour sur nos humeurs (rythmes circadiens) et l'origine de la vie (chimie intra-galactique). Une deuxième partie présente cette extraordinaire invention qu'est le laser, qui est venu bouleverser le domaine chimie et lumière. Par ailleurs, lumière et couleur, c'est évidemment indissociable. Cela est illustré par les merveilleuses créations de la nature qui inspirent nos écrans. La troisième partie traite d'applications industrielles. On y présente l'effet photovoltaïque et ses nouvelles versions, puis on revient sur les surprenantes applications industrielles des lasers qu'on croirait réservées à la science-fiction. L'ouvrage est conçu pour un public doté d'une culture scientifique de base. Les treize chapitres sont écrits par les meilleurs spécialistes en charge des importants développements actuels et qui se sont tous attachés à rester accessibles
Azo oxide gels for optical storage (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzo oxide gels for optical storageFrederic Chaput, Didier Riehl, Yves Levy, and Jean Pierre BoilotCite this: Chem. Mater. 1993, 5, 5, 589–591Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/cm00029a001https://doi.org/10.1021/cm00029a001research-articleACS PublicationsRequest reuse permissionsArticle Views409Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Surface Passivation Effect on SGOI Nanowire Biosensor in High Ge Fraction Fabrication (2013)

The oxidation of an SiGe-on-Insulator (SGOI) that is caused by Ge condensation increases the fraction of Ge therein and significantly increases the hole mobility. This effect can be exploited to improve the sensitivity of SGOI nano-wires. However, previous investigations by the authors have revealed that the sensitivity of SGOI nano-wires is reduced when the Ge fraction increase over 20%, because a high Ge fraction destabilizes the surface state of SiGe. In this work, a top surface passivation PECVD SiO 2 layer that was deposited on a Si 0.8 Ge 0.2 nano-wire improved its sensitivity to approximately 1.3 times that of a nano-wire sample without a top passivation layer.
Inflammation in ischemic heart disease: Response to tissue injury or a pathogenetic villain? (1999)

Time for primary review 32 days. 

The presence of inflammatory cells in the ischemic myocardial tissues has traditionally been believed to represent pathophysiologic response to injury [1]. It is only recently that inflammation has been related to the pathogenesis of acute coronary syndromes [2,3], reperfusion injury to ischemic myocardium [4], restenosis after angioplasty [5–7], failure of cardiac transplant [8], and chronic heart failure [9]. Accordingly, the relationship between inflammation with atherosclerosis and myocardial ischemia is now an area of active investigation.

Accumulation of polymorphonuclear leukocytes (PMN) and their activation are key features of inflammatory reaction associated with acute myocardial ischemia-reperfusion [3]. Experimental studies have shown that influx of PMNs into tissues results in tissue injury beyond that caused by ischemia alone [10,11]. It has also become apparent that the recruitment of PMNs during ischemia-reperfusion involves numerous mediators [3,4]. The causative role of PMNs in reperfusion injury in animals is supported by the observations of reduction in microvascular dysfunction and tissue injury by strategies that prevent PMN influx in tissues by either a decrease in the number of circulating PMNs [12], or prevent PMN activation [13]. Other studies [14] have shown that inhibition of release of PMN-derived mediators of tissue injury [14] or blockade of adhesion molecules on PMNs [15,16] and/or endothelial cells [17] also reduce tissues injury. Many aspects of inflammation as a participant in myocardial ischemia in animal models have been reviewed in the recent past [16–19].

In this report, we review our current understanding of inflammation in myocardial ischemia in patients with myocardial ischemia. If the concept of a causative role of inflammation, especially PMN accumulation and activation, in ischemic heart disease (IHD) is proven, anti-inflammatory therapy may be designed to prevent and treat this common … 

* Corresponding author. Tel.: +1-352-379-4160; fax: +1-352-379-4161 mehta{at}medmac.ufl.edu
Instruction issue logic for high-performance, interruptable pipelined processors (1987)

The performance of pipelined processors is severely limited by data dependencies. In order to achieve high performance, a mechanism to alleviate the effects of data dependencies must exist. If a pipelined CPU with multiple functional units is to be used in the presence of a virtual memory hierarchy, a mechanism must also exist for determining the state of the machine precisely. In this paper, we combine the issues of dependency-resolution and preciseness of state. We present a design for instruction issue logic that resolves dependencies dynamically and, at the same time, guarantees a precise state of the machine, without a significant hardware overhead. Detailed simulation studies for the proposed mechanism, using the Lawrence Livermore loops as a benchmark, are presented.
Measurement of Higgs boson decay into b-quarks in associated production with a top-quark pair in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector (2022)

A bstract The associated production of a Higgs boson and a top-quark pair is measured in events characterised by the presence of one or two electrons or muons. The Higgs boson decay into a b -quark pair is used. The analysed data, corresponding to an integrated luminosity of 139 fb − 1 , were collected in proton-proton collisions at the Large Hadron Collider between 2015 and 2018 at a centre-of-mass energy of $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV. The measured signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model, is $$ {0.35}_{-0.34}^{+0.36} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mn>0.35</mml:mn> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>0.34</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>0.36</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> . This result is compatible with the Standard Model prediction and corresponds to an observed (expected) significance of 1.0 (2.7) standard deviations. The signal strength is also measured differentially in bins of the Higgs boson transverse momentum in the simplified template cross-section framework, including a bin for specially selected boosted Higgs bosons with transverse momentum above 300 GeV.
Zerfall von Tropfen in beschleunigten Gasströmungen (2003)

Abstract No abstracts.
Ultraviolet to near infrared response of optically triggered nonvolatile memories based on platinum nano-particles and high-k dielectrics on a SOI substrate (2012)

We report a unique optically-triggered nonvolatile memory based on Platinum nano-particles embedded in a dielectric stack. A wide hysteresis at low operating voltages and a large optical response from 220 nm to 900 nm were demonstrated.