gebhart/patrepeval huggingface dataset:
Fluid Flow Regulation of Revascularization and Cellular Organization in a Bioengineered Liver Platform (2016)

Overall, we were able to unveil the potential central role of discrete mechanical stimulation through the NO pathway in the revascularization and cellular organization of a bioengineered liver. Last, we propose that this organ bioengineering platform can contribute significantly to the identification of physiological mechanisms of liver organogenesis and regeneration and improve our ability to bioengineer livers for transplantation.
Defending financial infrastructures through early warning systems (2009)

Recent evidence of successful Internet-based attacks and frauds involvingnancial institutions highlights the inadequacy of the existing protection mechanisms, in which each instutition implements its own isolated monitoring and reaction strategy. Analyzing on-line activity and detecting attacks on a large scale is an open issue due to the huge amounts of events that should be collected and processed. In this paper, we propose a large-scale distributed event processing system, called intelligence cloud, allowing the nancial entities to participate in a widely distributed monitoring and detection effort through the exchange and processing of information locally available at each participating site. We expect this approach to be able to handle large amounts of events arriving at high rates from multiple domains of the financial scenario. We describe a framework based on the intelligence cloud where each participant can receive early alerts enabling them to deploy proactive countermeasures and mitigation strategies. Copyright © 2009 ACM.
Current and future perspectives on recombinant growth hormone for the treatment of obesity (2007)

The similarities between patients with untreated growth hormone (GH) deficiency and those with the cardiometabolic syndrome and the beneficial effects of recombinant human GH (rhGH) on body composition have led to the hypothesis that rhGH treatment may have utility in obesity. GH release is reduced in the setting of obesity, primarily due to hyperinsulinism and increased free fatty acid levels. We reviewed the outcomes of 23 clinical studies carried out between 1987 and 2006 that examined the effects of rhGH administration in the obese state. Typically, changes in overall body weight do not occur with rhGH therapy; however, assessment of body composition demonstrates reductions in visceral abdominal fat. Data on the effects of rhGH on lipid and carbohydrate metabolic profiles in obese patients are less clear-cut, with a subset of studies showing a beneficial effect and others a neutral effect. Given the increasing burden of obesity in the general population and the current paucity of effective therapies, it is useful to consider the data on rhGH and obesity from a clinical perspective to highlight potential treatment strategies that harness the somatotropic axis.
Sub-optical-cycle control of free electrons by optical near-fields (2017)

In this contribution we report on research of the interaction between optical near-fields of periodic nanostructures and free-electron beams with potential application in future miniaturized laser-based accelerating devices [1, 2], in ultrafast electron microscopy or diffraction experiments [3, 4] or in photon-induced near-field electron microscopy [5]. Here we experimentally demonstrate a technique allowing sub-optical cycle temporal gating and streaking of electrons at sub-relativistic energies (25–30 keV). A focused electron beam interacts with the near-field mode induced by infrared femtosecond laser pulses on the surface of a silicon nanograting. The field pattern above the surface of a periodic structure can be decomposed to its spatial Fourier components, which propagate along the surface with different phase velocities. Synchronization of the phase velocity of a particular spatial harmonic with the velocity of the co-propagating electrons leads to efficient energy transfer between the laser field and electrons [1, 2]. As this interaction is linear in electric field, the temporal structure of the oscillating electromagnetic field of the femtosecond laser pulse is imprinted to the electron beam energy and/or transverse momentum with sub-cycle precision (200 as in this experiment [6]).
Detection of Cytokeratin 19 mRNA and CYFRA 21–1 (Cytokeratin 19 Fragments) in Blood of Tunisian Women with Breast Cancer (2008)

Cytokeratin 19 (CK19) is an acidic protein of 40 kDa that is part of the cytoskeleton of epithelial cells. It is highly expressed by all epithelial cells and represents a useful indicator of epithelial differentiation. The soluble fragment of CK19 (CYFRA 21–1) can be a useful circulating tumor marker and can be detected in the serum of cancer patients. The development of metastasis in patients with cancer of epithelial origin is due to the migration of tumor cells from the original tumor to distant organs. In order to detect micrometastasis in patients with breast cancer, we evaluated and compared CK19 gene expression using RT-PCR in blood samples collected from 80 healthy women and 80 patients with localized or metastatic breast cancer. The concentration of the soluble CK19 fragment CYFRA 21–1 was measured in serum of all study subjects by radioimmunoassay employing specific monoclonal antibodies. The relationship between the expression of this molecular marker and clinical stage, tumor differentiation and CK19 mRNA transcripts was investigated. We found that CK19 mRNA expression in blood (as a direct index of the presence of circulating tumor cells) was not correlated with CYFRA 21–1.
Homogeneity of Grain Refinement of Aluminum Alloy with Compressive Torsion Processing (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A Proposal of Storage Power Control Method with Data Placement Control (2015)

In recent years, the scale of datacenters has become larger due to the explosive increase in the amount of digital data. As a result, the growth of energy consumption is an important factor in the management cost of datacenters. Storing and processing such large volumes of data by database applications are the core technologies in this Big Data era. However, storage accounts for a significant percentage of a datacenter’s energy consumption. Therefore, we try to reduce the energy of storage to save on the total cost of datacenters. The purpose of this study is to reduce the energy consumption of storage while minimizing the deterioration of application performance. Although many methods for storage energy saving have been discussed, since it is difficult to control it efficiently only at the storage level, we have investigated the storage power control mechanism on middleware (database) layer. In this paper, we use TPC-H (a database benchmark) as an application example of data processing. We evaluate the data placement control method of storage proposed for energy saving in the database runtime processing suitable for a largescale environment with many HDDs.
Renal replacement therapy in acute kidney injury: controversy and consensus (2015)

Renal replacement therapies (RRTs) represent a cornerstone in the management of severe acute kidney injury. This area of intensive care and nephrology has undergone significant improvement and evolution in recent years. Continuous RRTs have been a major focus of new technological and treatment strategies. RRT is being used increasingly in the intensive care unit, not only for renal indications but also for other organ-supportive strategies. Several aspects related to RRT are now well established, but others remain controversial. In this review, we review the available RRT modalities, covering technical and clinical aspects. We discuss several controversial issues, provide some practical recommendations, and where possible suggest a research agenda for the future.
Propagation Measurement System and Approach at 140 GHz-Moving to 6G and Above 100 GHz (2018)

With the relatively recent realization that millimeter wave frequencies are viable for mobile communications, extensive measurements and research have been conducted on frequencies from 0.5 to 100 GHz, and several global wireless standard bodies have proposed channel models for frequencies below 100 GHz. Presently, little is known about the radio channel above 100 GHz where there are much wider unused bandwidth slots available. This paper summarizes wireless communication research and activities above 100 GHz, overviews the results of previously published propagation measurements at D-band (110-170 GHz), provides the design of a 140 GHz wideband channel sounder system, and proposes indoor wideband propagation measurements and penetration measurements for common materials at 140 GHz which were not previously investigated.
Estimation of maximum Doppler frequency for handoff decisions (2002)

A previous paper considered the problem of adaptively determining the measurement averaging interval for handoffs through the estimation of the maximum Doppler frequency, f/sub D/. The investigation is continued with refined estimates for f/sub D/ and approaches to bias correction. An exact analysis for the f/sub D/ estimate as a function of the squared deviations of the logarithmically compressed signal envelope is presented. An extension of the algorithm for robustness in a Rician fading environment is given. The performance of the algorithm in the presence of additive Gaussian noise is analyzed. The role of the noise bandwidth is quantified. The effect of cochannel interference on the estimate is negligible.
Validation of the Advanced Plant Habitat Facility on ISS (2018)

A fully automated plant growth facility for conducting plant research supporting space biology and food production projects on the ISS.
Simultaneous Catalytic Removal of NO and SO2 over Pt/ZSM-5 and V2O5–MoO3/TiO2 Catalysts (1987)

Abstract The simultaneous catalytic remov.al of NO and SO2 was examined over solid catalysts. SO2 oxidation was found to be more difficult than NO reduction with NH3. Pt/ZSM-5 and V2O5–MoO3/TiO2 showed high stationary activities for both reactions, suggesting a possibility of the simultaneous removal process of NO and SO2 by using solid catalysts.
Towards Ultra-Low Power Consumption VAD Architectures with Mixed Signal Circuits (2023)

A voice activity detector architecture based on an analog feature extractor and a mixed signal classification stage is proposed for ultra-low power activity. The feature extraction stage is composed of a set of analog band-pass filters and frame energy estimators. The classification stage has a fully connected first layer built with ultra-low power consumption ring oscillators, followed by gated recurrent unit layers. The ring oscillator based layer consumes nWs according to transient simulations performed in a low power 65 nm CMOS technology. Additionally it features the ability to perform the analog-to-digital conversion required to handle subsequent GRU layers, as well as the possibility of computing a non-linear function like sigmoid seizing the intrinsic non-linearity of the ring oscillator. Training and testing operations are made proving competitive classification performance between a baseline model and our proposed architecture. In light of this, proper features for deployment on power-restricted edge-computing applications are shown.
Sea-Launch for Small Satellites: An American/Russian Joint Venture (2025)

This paper describes practical means of bypassing the two major impediments to the commercial exploitation of space. These two impediments or constraints, are the affordability, reliability, and availability of launch vehicles on the one hand, and the affordability, availability, and flexibility of launch facilities on the other hand. As to the former, US launch vehicles are noted for their technological complexity, their high cost, and their susceptibility to single point failures. As to the latter, our land launch facilities are costly, inadequate and congested. Schedule delays on one launch cause delays for all succeeding launches from a given launch pad. The conversion of suitable military rockets (and specifically surplus SLBMs) into satellite launch vehicles will use already paid-for assets and will minimize costs for new construction as well as rocket fuels and oxidizers. Using floating sea-launch techniques already developed, the costs of launch pads, gantries, blockhouses, high capacity water cooling systems, etc., are largely eliminated. In order to bring the cost per pound in orbit down dramatically, a US/Russian joint venture, Sea Launch Services, has been initiated to convert Russian SLBMs into mobile floating boosters launchable from international waters.
ChemInform Abstract: A Convenient Palladium/Ligand Catalyst for Suzuki Cross‐Coupling Reactions of Arylboronic Acids and Aryl Chlorides. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ISOLATED INFRASPINATUS TEARS (2008)

Purpose of the study: When repairing rotator cuff tears, injury to the infraspinatus is generally a posterior extension of a supraspinatus tear. The description of isolated tears of the infraspinatus has not been to our knowledge reported in the literature. We report a series of 13 cases with more than one year follow-up. Material and methods: Thirteen patients underwent surgery for an isolated tear of the infraspinatus between 1995 and 2004. There were ten men and three women. Mean age at surgery was 47 years (range 34–62). The right shoulder was involved in seven of the thirteen cases, and the dominant shoulder in eight. A progressive onset was observed in eleven patients and nine had a history of treated calcified tendinopathy. Clinically, pain was the predominant symptom. The Jobe test was deficient in all patients as was external rotation (except one patient). The preoperative Constant score was 70 (range 62–87). X-rays revealed type C posterior calcification in nine patients. A full-thickness tear was observed in seven cases, a partial deep tear in three, and a partial superficial tear in three. Isolated fatty degeneration of the infraspinatus noted Goutallier grade 2 or greater was observed in seven patients. Open surgical repair was preformed in all patients. Results: Mean time to revision was 29 months (range 12–82). Subjectively, six patients were very satisfied, six were satisfied, and one was disappointed (failure by secondary tear). Two shoulder-hand syndromes were noted in the postoperative period. At last follow-up, the Constant score was 83.5 (range 64–97). All patients except one were satisfied with pain relief but the lack of force was significant. Discussion and conclusion: Isolated tears of the infra-spinatus are rare, but there is a notable relationship with calcifying tendinopathy of the same tendon. Repair should be undertaken before the development of fatty degeneration in order to improve the chances of force recovery.
Biological Treatment for Degenerative Disc Disease (2008)

Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of novel approaches, such as biological treatments that offer the potential to halt or even reverse disc degeneration and restore physiologic disc function, are very attractive. In this article, we first review the structural changes that occur during intervertebral disc degeneration and their relationship with discogenic back pain. Subsequently, we review the treatment approaches currently under clinical trial and laboratory investigation. Physiatrists specializing in spine care have the skill set required for administering intradiscal injections and supervising a comprehensive rehabilitation program after the procedures. Ultimately, the clinical use of any biological treatment discussed herein would require the collective efforts of physicians (such as physiatrists and surgeons) and researchers (such as chemical and biomedical engineers, biologists, and chemists).
Atomic force microscopy study of germination and killing of Bacillusatrophaeus spores (2009)

Bacterial spores such as Bacillus atrophaeus are one of the most resistant life forms known and are extremely resistant to chemical and environmental factors in the dormant state. During germination, as bacterial spores progress towards the vegetative state, they become susceptible to anti-sporal agents. B. atrophaeus spores were exposed to the non-nutritive germinant dodecylamine (DDA), a cationic surfactant that can also be used as a killing agent, for up to 60 min, or to the nutrient germinant L-alanine. In kinetic studies, 99% of the spores were killed within 5 min of exposure to DDA. Atomic force microscopy (AFM) can be used as a sensitive tool to assess how the structure of the spore coat changes upon exposure to germinants or killing agents. Changes in cell height and roughness over time of exposure to DDA were examined using AFM. DDA caused the spore height to decrease by >50%, which may have been due to a partial breakdown of the spore coat. Treatment of B. atrophaeus with the nutrient germinant resulted in a decrease in height of spores after 2 h of incubation, from 0.7 +/- 0.1 microm to 0.3 +/- 0.2 microm. However, treatment with L-alanine did not change the surface roughness of the spores, indicating that the changes that occur during germination take place underneath the spore coat. We propose that exposure to DDA at high concentrations causes pores to form in the coat layer, killing B. atrophaeus without the need to fully germinate spores.
The crystal and molecular structure of the tetra-n-butylammonium salt of the dianionic dimer of bis(1,2,3,4-tetrachlorobenzene-5,6-dithiolato)cobaltate (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe crystal and molecular structure of the tetra-n-butylammonium salt of the dianionic dimer of bis(1,2,3,4-tetrachlorobenzene-5,6-dithiolato)cobaltateM. J. Baker-Hawkes, Zvi Dori, Richard Eisenberg, and Harry B. GrayCite this: J. Am. Chem. Soc. 1968, 90, 16, 4253–4259Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/ja01018a012https://doi.org/10.1021/ja01018a012research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Aptamer Targeting the Apical‐Loop Domain Modulates pri‐miRNA Processing (2010)

Gaining maturity: RNA aptamers can serve as specific targeting molecules to modulate the processing of pri-miRNAs. This approach can be used to selectively interfere with microRNA regulation and may open new routes for the development of novel therapies.
Towards the development of a lateral flow immunochromatographic strip for the detection of soluble CD163 as a potential biomarker of neonatal sepsis (2020)

Background: Neonatal sepsis is one of the most common causes of infant morbidity and mortality. It is estimated that it harvests the lives of 5 out of 1000 births, and that the rate is 10 times higher in developing countries compared to developed countries, reaching up to 60% in some settings. Accurate and timely diagnosis of neonatal sepsis is difficult, since the gold standard for diagnosis, the blood culture, takes 24–48 hours. The rise of multidrug-resistant pathogens complicates the treatment process even more. Recently the Soluble Hemoglobin Scavenger Receptor CD163 (sCD163) has proven to be a promising sepsis biomarker. Methods and materials: In this work, we develop a prototype lateral flow immunochromatographic strip for the rapid detection of sCD163 in serum samples. We used bioinformatics to pinpoint exons encoding for the most immunogenic epitopes. A 306 bp fragment of the sCD163 ORF was subsequently cloned and expressed in E.coli BL21/DE3 as a 6xHis-fusion. The purified protein was used to immunize BALB/C mice to produce specific anti-sera. The purified antibodies were then conjugated to gold nanoparticles (GNPs). A lateral flow assay strip was assembled employing the sCD163 antibody-GNPs conjugate. Results: Our assay strip was highly sensitive and could detect down to 2.4 μg/mL of recombinant sCD163 in samples of 160 μL (2 drops). We could also detect sCD163 in samples of normal human serum. In addition to the small sample volume, the assay time was conveniently short and visible results were obtained after 20 m. Conclusion: In conclusion, the developed assay strip provides a sensitive, rapid, and low-cost tool for detection of scD163 and awaits further validations to be applied in the diagnosis of neonatal sepsis.
Wind farm models and control strategies (2005)

This report describes models and control strategies for 3 different concepts of wind farms. Initially, the potential in improvement of grid integration, structural loads and energy production is investigated in a survey of opportunities. Then simulation models are described, including wind turbine models for a fixed speed wind turbine with active stall control and a variable speed wind turbine with doubly-fed induction generator. After that, the 3 wind farm concepts and control strategies are described. The 3 concepts are AC connected doubly fed turbines, AC connected active stall turbines and DC connected active stall turbines. Finally, some simulation examples and conclusions are presented. (au)
Rapid synthesis of 14C forskolin by a route suitable for 11C labeling (1991)

Abstract Radiolabeled forskolin was synthesized by acetylation of deacetylforskolin with 14 C‐labeled acetic acid in the presence of dicyclohexylcarbodiimide. Separation of labeled forskolin of greater than 97% radiochemical purity was achieved by HPLC with a reversed‐phase column. The synthesis and purification of labeled forskolin were achieved in less than 30 min and the radiochemical yield of labeled forskolin after HPLC purification was about 30%, These methods are therefore applicable for production of 11 C‐forskolin which may be useful for PET second messenger imaging.