gebhart/patrepeval huggingface dataset:
Contribution à l'étude du système quinaire Ca++NHH+NOPOH2O XX. La polytherme de saturation du système ternaire Ca++NHNOH2O de 0° à 75° (1961)

Abstract Dans le but d'établir la polytherme de saturation du système ternaire Ca ++ NH 4 + NO − H 2 O entre 0° et 75°, nous avons effectué de nombreuses déterminations de solubilité aux températures de O°, 20°, 35°, 40°, 50° et 75°.
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination (2017)

Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (Mtb), remains a leading cause of morbidity and mortality worldwide, despite the widespread use of the only licensed vaccine, Bacille Calmette Guerin (BCG). Eradication of TB will require a more effective vaccine, yet evaluation of new vaccine candidates is hampered by lack of defined correlates of protection. Animal and human studies of intracellular pathogens have extensively evaluated polyfunctional CD4<sup>+</sup> T cells producing multiple pro-inflammatory cytokines (IFN-γ, TNF-α, and IL-2) as a possible correlate of protection from infection and disease. In this study, we review the published literature that evaluates whether or not BCG and/or novel TB vaccine candidates induce polyfunctional CD4<sup>+</sup> T cells and if these T cell responses correlate with vaccine-mediated protection. Ample evidence suggests that BCG and several novel vaccine candidates evaluated in animal models and humans induce polyfunctional CD4<sup>+</sup> T cells. However, while a number of studies utilizing the mouse TB model support that polyfunctional CD4<sup>+</sup> T cells are associated with vaccine-induced protection, other studies in mouse and human infants demonstrate no correlation between these T cell responses and protection. We conclude that induction of polyfunctional CD4<sup>+</sup> T cells is certainly not sufficient and may not even be necessary to mediate protection and suggest that other functional attributes, such as additional effector functions, T cell differentiation state, tissue homing potential, or long-term survival capacity of the T cell may be equally or more important to promote protection. Thus, a correlate of protection for TB vaccine development remains elusive. Future studies should address polyfunctional CD4<sup>+</sup> T cells within the context of more comprehensive immunological signatures of protection that include other functions and phenotypes of T cells as well as the full spectrum of immune cells and mediators that participate in the immune response against Mtb.
A Multi-Decision Sub-Band Voice Activity Detector (2006)

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 2006
An implantable antenna for communication with implantable medical devices (2000)

Numerous medical devices are implanted in the body for medical use. These include pacemakers and defibrillators, hormone pumps, nerve stimulators, and more. With the advancement and miniaturization of bio-electronics it is likely that the array of implantable medical devices will continue to expand in the years to come. Medical implants are intended to stay in the body for many years or decades, and it is often necessary to communicate with the device to download data about the health of the device or its batteries or the health of the patient, or to upload changes in settings or new procedures specified by the doctor. The design of antennas that can communicate with implantable devices is an interesting and challenging problem. The antenna must be small and long-term biocompatible, preferably able to be mounted on existing implant hardware or to utilize part of the hardware itself. The antenna must be electrically insulated from the body so as not to short out and be ineffective, and it must be efficient so as not to excessively drain the batteries. This paper describes the design and optimization of a spiral-shaped microstrip antenna attached to the 2x2x1/2 titanium battery pack of an implantable device imbedded in the body. The battery pack acts as the ground plane for the microstrip antenna and is in direct contact with the body. Two methods were used to optimize this antenna. The first was to simply try several designs in order to find the one that provided the best performance. This resulted in the antenna. The second method was to interface the XFDTD software (from Remcom, Inc.) which was used to simulate the antenna performance with iSIGHT (from Engineous, Inc.), an integration and optimization design program. Both antennas were prototyped and tested. The performance of both antennas is virtually identical. The use of optimization software saved significant man-hours in the optimization of this design.
Chaogate Parameter Optimization using Bayesian Optimization and Genetic Algorithm (2021)

Chaotic circuits have found application in various research areas, including cryptography. However, more effort has to be made to achieve the properties required for such circuits when it comes to their circuit design. We identify and optimize for regions of chaos in a simple three-transistor system known as a chaogate. We use simulations to study the dynamical behavior of the system treated as a one-dimensional map, and then maximize its chaotic and cryptographic behavior using artificial intelligence. We propose several useful metrics for the chaogate, such as the maximum Lyapunov exponent, and measure these metrics over the transistor parameter space. Finally, we apply Bayesian optimization and Genetic Algorithm to identify various chaogate designs in different technology nodes, which we visualize, compare, and use to propose future research.
Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity: Therapeutic potential against SARS-CoV-2 (COVID-19) (2022)

The therapeutic benefits of curcuminoids in various diseases have been extensively reported. However, little is known regarding their preventive effects on extensive immunosuppression. We investigated the immunoregulatory effects of a curcuminoid complex (CS/M), solubilized with stevioside, using a microwave-assisted method in a cyclophosphamide (CTX)-induced immunosuppressive mouse model and identified its new pharmacological benefits. CTX-treated mice showed a decreased number of innate cells, such as dendritic cells (DCs), neutrophils, and natural killer (NK) cells, and adaptive immune cells (CD4 and CD8 T cells) in the spleen. In addition, CTX administration decreased T cell activation, especially that of Th1 and CD8 T cells, whereas it increased Th2 and regulatory T (Treg) cell activations. Pre-exposure of CS/M to CTX-induced immunosuppressed mice restored the number of innate cells (DCs, neutrophils, and NK cells) and increased their activity (including the activity of macrophages). Exposure to CS/M also led to the superior restoration of T cell numbers, including Th1, activated CD8 T cells, and multifunctional T cells, suppressed by CTX, along with a decrease in Th2 and Treg cells. Furthermore,CTX-injected mice pre-exposed to CS/M were accompanied by an increase in the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase), which play an essential role against oxidative stress. Importantly, CS/M treatment significantly reduced viral loads in severe acute respiratory syndrome coronavirus2-infected hamsters and attenuated the gross pathology in the lungs. These results provide new insights into the immunological properties of CS/M in preventing extensive immunosuppression and offer new therapeutic opportunities against various cancers and infectious diseases caused by viruses and intracellular bacteria.
Measurement of ψ(2S) polarisation in pp collisions at √s = 7 TeV (2014)

The polarisation of prompt $\\psi(2S)$ mesons is measured by performing an angular analysis of $\\psi(2S)\\rightarrow \\mu^{+} \\mu^{-}$ decays using proton-proton collision data, corresponding to an integrated luminosity of 1.0 fb$^{-1}$, collected by the LHCb detector at a centre-of-mass energy of 7 TeV. The polarisation is measured in bins of transverse momentum $p_\\mathrm{T}$ and rapidity $y$ in the kinematic region $3.5&lt;p_\\mathrm{T}&lt;15$ GeV$/c$ and $2.0&lt;y&lt;4.5$, and is compared to theoretical models. No significant polarisation is observed.
No evidence of interallelic non-complementation in the gene complementary sex determiner of the honeybee (2012)

The objective of the study was to classifiy alleles of the gene complementary sex determiner, csd into complementation groups according to their interallelic relationships.This information was anticipated to provide clues on molecular mechanisms of csd-mediated sex determination and perhaps facilitate allele-assisted breeding.
ChemInform Abstract: Co(I)‐Catalyzed Inter‐ and Intramolecular Hydroacylation of Olefins with Aromatic Aldehydes. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo (2020)

In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in colon epithelial cells in vitro and in vivo. Following 6S treatment of HCT-116 cells, the intracellular GSH/GSSG ratio was initially diminished but was then elevated above the basal level. Intracellular reactive oxygen species (ROS) correlated inversely with the GSH/GSSG ratio. Further analysis using gene microarray showed that 6S upregulated the expression of Nrf2 target genes (AKR1B10, FTL, GGTLA4, and HMOX1) in HCT-116 cells. Western blotting confirmed upregulation, phosphorylation, and nuclear translocation of Nrf2 protein followed by Keap1 decrease and upregulation of Nrf2 target genes (AKR1B10, FTL, GGTLA4, HMOX1, and MT1) and glutathione synthesis genes (GCLC and GCLM). Pretreatment of cells with a specific inhibitor of p38 (SB202190), PI3K (LY294002), or MEK1 (PD098059) attenuated these effects of 6S. Using ultra-high-performance liquid chromatography–tandem mass spectrometry, we found that 6S modified multiple cysteine residues of Keap1 protein. In vivo 6S treatment induced Nrf2 nuclear translocation and significantly upregulated the expression of MT1, HMOX1, and GCLC in the colon of wild-type mice but not Nrf2–/– mice. Similar to 6S, a cysteine-conjugated metabolite of 6S (M2), which was previously found to be a carrier of 6S in vitro and in vivo, also activated Nrf2. Our data demonstrated that 6S and its cysteine-conjugated metabolite M2 activate Nrf2 in colon epithelial cells in vitro and in vivo through Keap1-dependent and -independent mechanisms.
The effect of action video game playing on the useful field of view (2004)

We have recently proposed that action video game play enhances several different aspects of visual attention1. Here we further test this view by assessing the effect of video game play on variants of the Useful Field of View (UFOV2), a task that requires subjects to locate a briefly presented peripheral target. Performance on the UFOV does not correlate well with standard tests of visual acuity but rather provides a measure of attentional resources and their spatial distribution. We have previously shown that habitual video game players (VGPs) outperform non-video game players (NVGPs) on this task. Here we show that they do so whether the target is presented in isolation or amongst distractors, suggesting that both automatic orienting and visual selective attention are improved in VGPs. We also extend these results to the case of divided attention by having subjects perform the peripheral localization task with and without a concurrent central discrimination task. VGPs exhibited markedly greater accuracy than NVGPs in the peripheral localization task in both conditions. In addition, VGPs outperformed NVGPs on the center discrimination task itself, suggesting that the increase in peripheral localization ability was not at the cost of decreased central attention. In each experiment, NVGPs were specifically trained on an action video game and showed similar enhancements. Together, these results support the view that action video game play leads to enhanced spatial attention and importantly demonstrates that this enhancement is not due to a redistribution of central attention resources to the visual periphery.
COMPARATIVE STUDIES OF SPECIFIC ACQUIRED SYSTEMIC TOLERANCE INDUCED BY INTRATHYMIC INOCULATION OF A SINGLE SYNTHETIC WISTAR-FURTH (RT1U) ALLO-MHC CLASS I (RT1.AU) PEPTIDE OR WAG (RT1U)-DERIVED CLASS I PEPTIDE1 (1998)

Of interest is our finding that IT injection of a short segment of WAG-derived MHC class I peptide induces active acquired tolerance similar to results obtained with the use of pure WF-derived peptide u-5 in the WF-to-ACI rat combination. It is noteworthy that we could not confirm the T helper (Th)1/Th2 paradigm in this model by initial cytokine analysis. Whether induction of tolerance by IT injection of allo-MHC peptides will have clinical usefulness must await results of similar studies in large animals. However, of major interest is the finding that a short segment of RT1.AU represents the tolerogenic
Implementation and evaluation of transparent fault-tolerant Web service with kernel-level support (2003)

Most of the techniques used for increasing the availability of Web services do not provide fault tolerance for requests being processed at the time of server failure. Other schemes require deterministic servers or changes to the Web client. These limitations are unacceptable for many current and future applications of the Web. We have developed an efficient implementation of a client-transparent mechanism for providing fault-tolerant Web service that does not have the limitations mentioned above. The scheme is based on a hot standby backup server that maintains logs of requests and replies. The implementation includes modifications to the Linux kernel and to the Apache Web server, using their respective module mechanisms. We describe the implementation and present an evaluation of the impact of the backup scheme in terms of throughput, latency, and CPU processing cycles overhead.
Preparation of Double Pickering Emulsions Stabilized by Chemically Tailored Nanocelluloses (2014)

Nanocelluloses are bio-based nanoparticles of interest as stabilizers for oil-in-water (o/w) Pickering emulsions. In this work, the surface chemistry of nanocelluloses of different length, nanofibrillated cellulose (NFC, long) and cellulose nanocrystals (CNC, short), was successfully tailored by chemical modification with lauroyl chloride (C12). The resulting nanofibers were less hydrophilic than the original and able to stabilize water-in-oil (w/o) emulsions. The combination of the two types of nanocelluloses (C12-modified and native) led to new surfactant-free oil-in-water-in-oil (o/w/o) double emulsions stabilized by nanocellulose at both interfaces. Characterization was performed with respect to droplet size distribution, droplet stability over time, and stability after centrifugation. Nanocellulose-based Pickering emulsions can be designed with a substantial degree of control, as demonstrated by the stability of the chemically tailored NFC double emulsions. Furthermore, it was demonstrated that increased nanofiber length leads to increased stability.
Cluster coarsening in zinc oxide thin films by postgrowth annealing (2006)

Postgrowth annealing was carried out on ZnO thin films grown by metal-organic chemical-vapor deposition. It was found from the scanning electron microscopy and atomic force microscopy measurements that the morphology of the thin films changed drastically after annealing. The as-grown thin films consist of fine nanoscale-sized sheets with random orientation. Upon annealing at 800°C, the ZnO nanosheets changed to three-dimensional nanoneedles. The different types of the mass transport mechanisms are discussed and correlated with the experimental results. A coarsening kinetics developed by Lifshitz and Slyozov [J. Phys. Chem. Solids 19, 35 (1961)] and Wagner [Z. Elektrochem. 65, 581 (1961)] was used to estimate the activation energy of the coarsening process. The activation energy of the Ostwald ripening in ZnO films was estimated in the first attempt, and the value is at around 1.33eV. Hall effect and photoluminescence measurements were carried out to investigate the effect of coarsening on electrical and optical properties of the ZnO thin films.
Supplementary Table 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq (2023)

Supplementary Table 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Influence of harvest time on quality of ‘valencia’ oranges and juice (2009)

‘Valencia’ oranges were harvested from Feb. to June 2007, and the effects of harvest time on fruit and juice quality were investigated. After reaching a peak in peel color in March, peel regreening occurred and juice content decreased. Soluble solids content (SSC) remained constant at 10.3% to 11.0% regardless of harvest time. However, juice from later harvested fruit had much lower titratable acidity (TA). Thus, the SSC : TA ratio steadily increased from 10.4 in February to 25.5 in June-harvested fruit. When individual sugars and acids were analyzed, it was found that the ratio increased due to a decrease in citric acid and an increase of sucrose over the season. Pectin content in juice increased with delayed harvest time, possibly due to a softening of albedo and membrane tissues that resulted in small amounts of these materials entering the juice during processing. Ascorbic acid content decreased throughout the harvest season. Phenolic hydroxycinnamic acids (HCAs), an unidentified alkaloid (UA), flavonoids including narirutin (NR), 6,8-di- C -glucosyl apigenin (DCGA) and narirutin-4´- O -glucoside (NRG), as well as limonoids including limonin glucoside (LG), nomilin glucoside (NG), nomilinic acid glucoside (NAG), limonin (L) and nomilin (N) aglycones were measured over the season. Total levels of the HCAs decreased continually until May then increased in June, and the alkaloid, UA, continually increased during the entire harvest season. Contents of flavonoids decreased or remained constant. Limonoids, including L and N, the major bitterness contributors, decreased over the season except LG and NG, which peaked in May. Volatile production for most compounds increased with delayed harvest time at least until May, including acetaldehyde, octanal, hexanal, decanal, ethanol, hexanol, E -2-hexenol, linalool, octanol, a-pinene, mycene, limonene, ethyl butanoate, ethyl hexanoate and methyl butanoate. Some compounds, such as methanol, valencene and ethyl acetate decreased with delayed harvest. Z -3-Hexenol and a-terpineol showed similar patterns, decreasing in April and May and increasing thereafter. The results indicate that fruit harvested in earlier in the season had better quality in terms of higher juice content, better SSC/TA ratio (April to May, 15.1–18.6 ratio), higher levels of ascorbic acid, flavonoids and other secondary metabolites. However, fruit harvested later in the season likely had more aroma and lower levels of bitter components.
Locating Monovalent Cations in the Grooves of B-DNA, (2001)

Here we demonstrate that monovalent cations can localize around B-DNA in geometrically regular, sequence-specific sites in oligonucleotide crystals. Positions of monovalent ions were determined from high-resolution X-ray diffraction of DNA crystals grown in the presence of thallium(I) cations (Tl(+)). Tl(+) has previously been shown to be a useful K(+) mimic. Tl(+) positions determined by refinement of model to data are consistent with positions determined using isomorphous F(Tl) - F(K) difference Fouriers and anomalous difference Fouriers. None of the observed Tl(+) sites surrounding CGCGAATTCGCG are fully occupied by Tl(+) ions. The most highly occupied sites, located within the G-tract major groove, have estimated occupancies ranging from 20% to 35%. The occupancies of the minor groove sites are estimated to be around 10%. The Tl(+) positions in general are not in direct proximity to phosphate groups. The A-tract major groove appears devoid of localized cations. The majority of the observed Tl(+) ions interact with a single duplex and so are not engaged in lattice interactions or crystal packing. The locations of the cation sites are dictated by coordination geometry, electronegative potential, avoidance of electropositive amino groups, and cation-pi interactions. It appears that partially dehydrated monovalent cations, hydrated divalent cations, and polyamines compete for a common binding region on the floor of the G-tract major groove.
Assessment of Modern Silicon Photomultiplier Radiation Hardness in a Nuclear Security Context (2018)

The impact of radiation damage on silicon photomultiplier (SiPM) performance is essential in evaluating their suitability for use in long-term applications and/or high-radiation environments. In this work multiple SiPMs are tested from Hamamatsu, Ketek, and SensL. SiPMs are exposed separately to both gamma ray and fast neutron fields up to 1000 kRad and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> neutrons/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> respectively. Characteristics of interest are pulse shape discrimination (PSD) with organic scintillators, energy resolution, noise, and signal amplitude. It is found that PSD is more dramatically impacted by radiation damage than energy resolution, and significant increases in noise levels are observed at the irradiation levels employed. Attenuation of the signal amplitude is only significant for some SiPMs, notably those that produce the largest charge integrals. As expected, performance in larger SiPMs deteriorates faster because noise levels increase more drastically compared to smaller SiPMs. Neutron activation is also shown to not be the primary factor in performance degradation.
memory: A scalable (2008)

Summary and outlook In this paper, we have analyzed the scaling behavior ofPCRAM technology in terms of the expected deviceproperties, the scaling properties of the phase-changematerials themselves, the performance of actualultrascaled prototype devices, and the fabricationchallenges that can be expected at future technologynodes. Simulations indicate that the critical value of theRESET current will continue to shrink rapidly with thesize of the phase-change memory element. We show thatthe properties of phase-change materials are generallyconserved with ﬁlms that have thicknesses as small asonly 10 nm, depending somewhat on the material. Forthinner ﬁlms,an increase in the crystallization temperatureis observed that makes these ﬁlms even better suited forPCRAM applications. Nanoparticles as small as 15 nmhave been fabricated and still show crystallization attemperatures that are comparable to bulk material formany cases. Functioning devices have been fabricatedusing ﬁlms as thin as 3 nm, with cross-sectional areas ofonly 60 nm