gebhart/patrepeval huggingface dataset:
Asymmetric Synthesis of Aryloxypropanolamines via OsO4‐Catalyzed Asymmetric Dihydroxylation. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Spectrum Occupancy Prediction Exploiting Time and Frequency Correlations Through 2D-LSTM (2020)

The identification of spectrum opportunities is a pivotal requirement for efficient spectrum utilization in cognitive radio systems. Spectrum prediction offers a convenient means for revealing such opportunities based on the previously obtained occupancies. As spectrum occupancy states are correlated over time, spectrum prediction is often cast as a predictable time-series process using classical or deep learning-based models. However, this variety of methods exploits time-domain correlation and overlooks the existing correlation over frequency. In this paper, differently from previous works, we investigate a more realistic scenario by exploiting correlation over time and frequency through a 2D-long short-term memory (LSTM) model. Extensive experimental results show a performance improvement over conventional spectrum prediction methods in terms of accuracy and computational complexity. These observations are validated over the real-world spectrum measurements, assuming a frequency range between 832-862 MHz where most of the telecom operators in Turkey have private uplink bands.
FULLY COUPLED, 6-DOF TO URANS, MODELING OF CAVITATING FLOWS AROUND A SUPERCAVITATING VEHICLE (2003)

A preconditioned, homogenous, multiphase, unsteady Reynolds Averaged Navier-Stokes (URANS) scheme is dynamically coupled to a six-degree-of-freedom (6DOF) rigid body motion model. Details of the numerical and physical modeling associated with the coupled URANS-6DOF code are presented. Results are presented for an application to a notional supercavitating vehicle. Among other important observations, the vehicle dynamics solution is seen to approach a quasi-steady limit cycle behavior. This compares favorably with integrated results of a reduced order dynamics model.
Recent developments in polycrystalline oxide fiber laser materials: production of Yb-doped polycrystalline YAG fiber (2011)

Laser quality, polycrystalline oxide fibers offer significant advantages over state-of-the-art silica fiber for high energy lasers. Advanced ceramic processing technology, along with a novel powder production process, has potential to produce oxide fibers with an outstanding optical quality for use in the fiber laser applications. The production of contaminant-free green fibers with a high packing density, as well as uniform packing distribution, is a key factor in obtaining laserquality fibers. High quality green fibers are dependent on the powder quality combined with the appropriate slurry formulation. These two fundamental technologies were successfully developed at UES, and used to produce Yb-doped yttrium aluminum garnet (YAG) fibers with high optical quality, high chemical purity, and suitable core diameters down to 20-30 microns.
High-spin study of162Ta (2011)

Excited states in the odd-odd neutron deficient nucleus ${}^{162}\mathrm{Ta}$ ($Z=73$, $N=89$) have been studied for the first time. The gamma spectroscopy analysis using $\ensuremath{\gamma}\ensuremath{-}\ensuremath{\gamma}\ensuremath{-}\ensuremath{\gamma}$ coincidences revealed a strongly coupled rotational structure that was established up to large angular momentum states. The rotational band was assigned to the configuration $\ensuremath{\pi}{h}_{11/2}[514]9/2\ensuremath{\bigotimes}\ensuremath{\nu}{i}_{13/2}[660]1/2$ based on its rotational and electromagnetic properties. The data are interpreted within the framework of total Routhian surface calculations, which suggests an axially symmetric shape with a $\ensuremath{\gamma}$-soft minimum at ${\ensuremath{\beta}}_{2}\ensuremath{\approx}0.16$ and $\ensuremath{\gamma}\ensuremath{\approx}{6}^{\ensuremath{\circ}}$. The crossing of the signature partners observed in heavier ($N\ensuremath{\geqslant}91$) odd-odd nuclides in this mass region is found to be absent at $N=89$. This might be correlated with a change in $S$-band structure above the paired band crossing at these neutron numbers.
Constitutive Transcriptional Control Signals of the Herpes Simplex Virus tk Gene (1983)

Most of the molecular details of eukaryotic transcriptional regulation are poorly understood. Two important facts, however, have been established. First, a eukaryotic gene can exist either in a transcriptionally active state or in a repressed state. This state of activity is dictated by as yet ill-defined temporal and tissue-specific considerations imposed by the ontogeny of the organism.1 Second, an active eukaryotic gene is transcribed at a specific efficiency that represents an inherent property of that gene.2 These rather general observations lead one to view the process of transcription initiation as a two-component system. One component dictates whether or not a gene is actively expressed. This first component can be compared with the “on/off switch” of an electric blender. A second component involved in regulating transcription initiation is implemented when the on/off switch has been activated. This second component is analogous to the series of “speed buttons” on an electric blender...
High-Rate LiFePO4 Lithium Rechargeable Battery Promoted by Electrochemically Active Polymers (2008)

LiFePO4 is a promising cathode material for the next generation of a lithium-ion rechargeable battery because of its low-cost, safety, excellent cyclability, and large capacity. Moreover, its voltage, 3.45 V versus lithium, is compatible with the window of a solid-polymer Li-ion electrolyte. Of particular interest for commercial applications is its safety and energy capacity at high power output and at short recharge times. We report here a systematic investigation of the enhancement of capacity at high rates of charge and discharge by substitution of a conductive, electrochemically active polymer for some or all of the deadweight conductive carbon and binder used conventionally to enhance performance of a secondary battery. Polypyrrole (PPy) and polyaniline (PANI) were used as the conductive polymers; two methods, electrochemical deposition and simultaneous chemical polymerization, were used to prepare the LiFePO4/polymer composite cathodes. Our results show that significantly improved capacity and rate capability can be achieved in such composite cathodes and that the electrodeposited carbon-coated LiFePO4/PPy composite exhibits the best performance.
A phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer. (2014)

TPS2641 Background: There is significant cross-talk between PI3-kinase (PI3K) pathway and androgen receptor (AR) signaling pathways, respectively, which are both critical for cell survival in castrate-resistant prostate cancer (CRPC). The primary study objective is to determine the safety profile and maximum tolerated dose (MTD) of BKM120 (pan-PI3K inhibitor) in combination with abiraterone/prednisone (A/P) in CRPC patients. The secondary study objectives are to assess the impact of PTEN status on duration of response/time to progression in the expansion cohort, and to evaluate the impact of BKM120 on a PI3-kinase activation fingerprint in metastatic bone or lymph node tissue samples. An exploratory objective of the study is to assess the effect of BKM120 on transcription of a set of AR-regulated genes in metastatic bone biopsy samples. Methods: The trial design involves a 14 day lead-in phase with BKM120 alone, to assess single-agent toxicity and perform correlative studies. A/P is combined with BKM120 at the end of 14 days using the standard 3+3 dose-escalation design with 3 dose levels of BKM120 (80 mg, 100 mg, 120 mg, respectively), and participants are assessed for safety and MTD on the combination therapy. The MTD dose will be used in the expansion cohort to assess safety of the combination. To determine pharmacodynamic impact of single agent BKM120 on the PI3K activation signature at a metastatic site, a mandatory CT-guided bone or lymph node biopsy is performed prior to BKM120 initiation and at the end of 2 weeks on BKM120 single-agent therapy. Immunohistochemical (IHC) stains for four markers (p-AKT, p-S6, PTEN and stathmin) are used to obtain a PI3K activation score, based on the quartile levels of continuous staining scores of each marker. Clinical trial information: NCT01741753.
Preparation of PMMA Nanoparticles Loaded with Benzophenone‐3 through Miniemulsion Polymerization (2012)

Abstract Summary: The present paper analyzes the production of poly(methyl methacrylate) – PMMA – nanoparticles loaded with benzophenone‐3 through miniemulsion polymerization. The obtained product is homogeneous and stable, allowing for preparation of photo‐protective formulations. It is observed in particular that bezophenone‐3 interacts with the reacting system, promoting the growth of the PMMA chains produced in miniemulsion.
Moving speech recognition from software to silicon: the in silico vox project (2006)

To achieve much faster decoding, or much lower power consumption, we need to liberate speech recognition from the artificial constraints of its current software-only form, and move the essential computations directly into silicon. There are vast efficiencies waiting to be unlocked in this application – we need the proper architecture to do so. We report results from a firstgeneration hardware architecture simulated at bit-level, and partial, working FPGA-based prototypes. Simulation results show that rather modest hardware designs, running 10-20X slower than conventional processors, can already decode at 0.6 xRT, running the standard 5K Wall Street Journal benchmark.
Microwave receivers with direct digitization (2009)

Superconductor analog-to-digital converters (ADCs) and ultrafast digital circuitry enable processing of microwave signals entirely in the digital domain. We have designed and demonstrated a wide variety of continuous-time bandpass delta-sigma modulators using Josephson junction comparators. Featuring sampling frequencies up to 30 GHz, single-chip digital receivers have been demonstrated by connecting a rapid single flux quantum (RSFQ) digital circuitry with these ADCs. These receiver chips, cooled to 4 K by cryogen-free refrigerators, have been used with room-temperature digital processors to demonstrate reception of microwave signals for X-band satellite communications and Link-16 data links. To date, the highest frequency of direct digitization is 21 GHz for satellite communication. We report recent advances in ADC design to obtain higher dynamic range.
A Novel Nanoslotted Quadrabeam Photonic Crystal Cavity Sensor with High Sensitivity and High Q-factor (2014)

We experimentally demonstrate a sensor based on a novel nanoslotted quadrabeam photonic-crystal cavity (NQPC). The NQPC possesses both high-sensitivity and high-Q factor. We achieved sensitivity of 451nm/RIU and Q-factor &gt;7000 in water at telecom-wavelength range.
Aggregation and Surface Morphology of a Poly(ethylene oxide)-block-polystyrene Three-Arm Star Polymer at the Air/Water Interface Studied by AFM (2002)

The behavior of a three-arm star amphiphilic copolymer, PEO3-b-PSD3 were investigated at the air/water interface through atomic force microscopy (AFM) images of the monolayer on mica. The Langmuir-Blodgett (LB) films were prepared on the KSV 5000 system with a platinum Wilhelmy plate. The PEO3-b-PS3 three arm star used were prepared by the anionic polymerization of ethylene oxide followed by the ATRP synthesis of styrene. It was assumed that the characteristics of the monolayer at the air/water interface remained unchanged upon transfer to the mica surface.
Bone Grafting Severe Glenoid Defects in Revision Shoulder Arthroplasty (2008)

Level III Prognostic study.
Spin state dependent redox properties of the [Fe(III)(X-sal)2trien]+ spin-equilibrium system in solution (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpin state dependent redox properties of the [Fe(III)(X-sal)2trien]+ spin-equilibrium system in solutionKarl M. Kadish, K. Das, D. Schaeper, Connie L. Merrill, Byron R. Welch, and Lon J. WilsonCite this: Inorg. Chem. 1980, 19, 9, 2816–2821Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ic50211a065https://doi.org/10.1021/ic50211a065research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Learn-to-Score: Efficient 3D Scene Exploration by Predicting View\n Utility (2018)

Camera equipped drones are nowadays being used to explore large scenes and\nreconstruct detailed 3D maps. When free space in the scene is approximately\nknown, an offline planner can generate optimal plans to efficiently explore the\nscene. However, for exploring unknown scenes, the planner must predict and\nmaximize usefulness of where to go on the fly. Traditionally, this has been\nachieved using handcrafted utility functions. We propose to learn a better\nutility function that predicts the usefulness of future viewpoints. Our learned\nutility function is based on a 3D convolutional neural network. This network\ntakes as input a novel volumetric scene representation that implicitly captures\npreviously visited viewpoints and generalizes to new scenes. We evaluate our\nmethod on several large 3D models of urban scenes using simulated depth\ncameras. We show that our method outperforms existing utility measures in terms\nof reconstruction performance and is robust to sensor noise.\n
Multifunctional hyperuniform cellular networks: optimality, anisotropy and disorder (2018)

Disordered hyperuniform heterogeneous materials are new, exotic amorphous states of matter that behave like crystals in the manner in which they suppress volume-fraction fluctuations at large length scales, and yet are statistically isotropic with no Bragg peaks. It has recently been shown that disordered hyperuniform dielectric two-dimensional (2D) cellular network solids possess complete photonic band gaps comparable in size to photonic crystals, while at the same time maintaining statistical isotropy, enabling waveguide geometries not possible with photonic crystals. Motivated by these developments, we explore other functionalities of various 2D ordered and disordered hyperuniform cellular networks, including their effective thermal or electrical conductivities and elastic moduli. We establish the multifunctionality of a class of such low-density networks by demonstrating that they maximize or virtually maximize the effective conductivities and elastic moduli. This is accomplished using the machinery of homogenization theory, including optimal bounds and cross-property bounds, and statistical mechanics. We rigorously prove that anisotropic networks consisting of sets of intersecting parallel channels in the low-density limit, ordered or disordered, possess optimal effective conductivity tensors. For a variety of different disordered networks, we show that when short-range and long-range order increases, there is an increase in both the effective conductivity and elastic moduli of the network. Moreover, we demonstrate that the effective conductivity and elastic moduli of various disordered networks derived from disordered 'stealthy' hyperuniform point patterns possess virtually optimal values. We note that the optimal networks for conductivity are also optimal for the fluid permeability associated with slow viscous flow through the channels as well as the mean survival time associated with diffusion-controlled reactions in the channels. In summary, we have identified ordered and disordered hyperuniform low-weight cellular networks that are multifunctional with respect to transport (e.g., heat dissipation and fluid transport), mechanical and electromagnetic properties, which can be readily fabricated using 3D printing and lithographic technologies.
FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells (2002)

Biosynthesis of lipids was investigated in growing 293 cells stably expressing fatty acid (FA) transport protein 1 (FATP1), a bifunctional polypeptide with FA transport as well as fatty acyl-CoA synthetase activity. In short-term (30 s) incubations, FA uptake was increased in FATP1 expressing cells (C8 cells) compared with the vector (as determined by BODIPY 3823 staining and radioactive FA uptake). In long-term (4 h) incubations, incorporation of [(14)C]acetate, [3H]oleic acid, or [(14)C]lignoceric acid into 1,2,3-triacyl-sn-glycerol (TG) was elevated in C8 cells compared with vector, whereas incorporation of radiolabel into glycerophospholipids was unaltered. The increase in TG biosynthesis correlated with an increase in 1,2-diacyl-sn-glycerol acyltransferase activity in C8 cells compared with vector. In contrast, incorporation of [(14)C]acetate into sphingomyelin (SM) and cholesterol, and [3H]oleic acid or [(14)C]lignoceric acid into SM was reduced due to a reduction in de novo biosynthesis of these lipids in C8 cells compared with vector. The results indicate that exogenously supplied FAs, and their subsequently produced acyl-CoAs, are preferentially channeled by an FATP1 linked mechanism into the TG biosynthetic pathway and that such internalized lipids down-regulate de novo SM and cholesterol metabolism in actively growing 293 cells.
Synthesis of a template-associated peptide designed as a transmembrane ion channel former (1999)

We describe the design and the Fmoc/tBu solid phase synthesis of a 20 residue long peptide containing five regularly distributed lysines. Cyclization of this peptide was achieved using BOP as coupling agent. After side-chain deprotection, all the basic residues were iodoacetylated and then allowed to react either with a C-terminal free COOH peptide or with peptides bearing a cysteamide group. The final pentameric templates were identified by mass and amino acid analysis which gave data compatible with the expected values.
A porous Brønsted superacid as an efficient and durable solid catalyst (2018)

A porous superacid material with a high surface area and abundant accessible active sites is rationally designed, showing outstanding catalytic activities and durability in industrial chemical transformations.
Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice (2016)

Isoliquiritigenin (ILG) is a flavonoid derived from Glycyrrhiza uralensis and potently suppresses NLRP3 inflammasome activation resulting in the improvement of diet-induced adipose tissue inflammation. However, whether ILG affects other pathways besides the inflammasome in adipose tissue inflammation is unknown. We here show that ILG suppresses adipose tissue inflammation by affecting the paracrine loop containing saturated fatty acids and TNF-α by using a co-culture composed of adipocytes and macrophages. ILG suppressed inflammatory changes induced by the co-culture through inhibition of NF-κB activation. This effect was independent of either inhibition of inflammasome activation or activation of peroxisome proliferator-activated receptor-γ. Moreover, ILG suppressed TNF-α-induced activation of adipocytes, coincident with inhibition of IκBα phosphorylation. Additionally, TNF-α-mediated inhibition of Akt phosphorylation under insulin signaling was alleviated by ILG in adipocytes. ILG suppressed palmitic acid-induced activation of macrophages, with decreasing the level of phosphorylated Jnk expression. Intriguingly, ILG improved high fat diet-induced fibrosis in adipose tissue in vivo. Finally, ILG inhibited TLR4- or Mincle-stimulated expression of fibrosis-related genes in stromal vascular fraction from obese adipose tissue and macrophages in vitro. Thus, ILG can suppress adipose tissue inflammation by both inflammasome-dependent and -independent manners and attenuate adipose tissue fibrosis by targeting innate immune sensors.
How to Reduce Action Space for Planning Domains? (Student Abstract) (2022)

While AI planning and Reinforcement Learning (RL) solve sequential decision-making problems, they are based on different formalisms, which leads to a significant difference in their action spaces. When solving planning problems using RL algorithms, we have observed that a naive translation of the planning action space incurs severe degradation in sample complexity. In practice, those action spaces are often engineered manually in a domain-specific manner. In this abstract, we present a method that reduces the parameters of operators in AI planning domains by introducing a parameter seed set problem and casting it as a classical planning task. Our experiment shows that our proposed method significantly reduces the number of actions in the RL environments originating from AI planning domains.
Supplementary Figure 3 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by <i>In Vivo</i> Microscopy and Single-Cell Pharmacodynamics (2023)

Supplementary Figure 3 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by &lt;i&gt;In Vivo&lt;/i&gt; Microscopy and Single-Cell Pharmacodynamics
Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes (2016)

We have investigated the effects of hyperglycemia on cardiomyocyte physiology and ventricular function. Our results indicate that defective Ca<sup>2+</sup> handling is a critical component of the progressive deterioration of cardiac performance of the diabetic heart.
On Interference Avoidance Through Inter-Cell Interference Coordination (ICIC) Based on OFDMA Mobile Systems (2012)

The widely accepted OFDMA air interface technology has recently been adopted in most mobile standards by the wireless industry. However, similar to other frequency-time multiplexed systems, their performance is limited by inter-cell interference. To address this performance degradation, interference mitigation can be employed to maximize the potential capacity of such interference-limited systems. This paper surveys key issues in mitigating interference and gives an overview of the recent developments of a promising mitigation technique, namely, interference avoidance through inter-cell interference coordination (ICIC). By using optimization theory, an ICIC problem is formulated in a multi-cell OFDMA-based system and some research directions in simplifying the problem and associated challenges are given. Furthermore, we present the main trends of interference avoidance techniques that can be incorporated in the main ICIC formulation. Although this paper focuses on 3GPP LTE/LTE-A mobile networks in the downlink, a similar framework can be applied for any typical multi-cellular environment based on OFDMA technology. Some promising future directions are identified and, finally, the state-of-the-art interference avoidance techniques are compared under LTE-system parameters.