gebhart/patrepeval huggingface dataset:
Reverberation features identification from music recordings using the discrete wavelet transform (2010)

This paper presents a method of extracting reverberation features from music recordings. First, we perform a short time Fourier transform to transform the audio signal into a 2D time-frequency representation in which reverberation features appear as blurring of spectral features in the time dimension. Employing image analysis method we may quantitatively estimate the amount of reverberation by transforming the STFT “image” to a wavelet domain where we can perform efficient edge detection and characterization. Experiments demonstrate that quantitative estimates of reverberation time extracted in this way are strongly correlated with physical measurements.
Spectroscopic properties of binuclear palladium(0) and platinum(0) dibenzylideneacetone complexes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic properties of binuclear palladium(0) and platinum(0) dibenzylideneacetone complexesPierre D. Harvey, Fran Adar, and Harry B. GrayCite this: J. Am. Chem. Soc. 1989, 111, 4, 1312–1315Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://doi.org/10.1021/ja00186a024RIGHTS & PERMISSIONSArticle Views484Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (472 KB) Get e-Alerts Get e-Alerts
Disease-associated dominant negative CARD11 mutations interfere with the CARD11 Opening Step during antigen receptor signaling to NF-κB and JNK2 (2020)

Abstract CARD11 mediates lymphocyte activation by functioning as a scaffold in antigen receptor signaling to NF-κB, JNK, and mTOR. Antigen-induced CARD11 signaling proceeds through an ordered series of steps, including Opening, Cofactor Recruitment, Enzyme Activation, and Complex Disassembly. Recently, several forms of Primary Immunodeficiency have been described that are due to germline CARD11 mutations. One of these syndromes, Combined Immunodeficiency (CID) with atopy, is inherited in an autosomal dominant manner and caused by loss-of-function (LOF) CARD11 alleles, which display dominant negative activity that poisons signaling from co-expressed wild-type CARD11. To investigate the mechanistic basis for disease-associated dominant negative activity we reconstituted CARD11-deficient T cells with a panel of LOF CARD11 variants in the absence and presence of co-expressed wild-type CARD11. In the absence of wild-type CARD11, the LOF variants were indistinguishable, such that each variant failed to promote the signal-induced 1) recruitment of the cofactors Bcl10, HOIP, and MALT1 to CARD11, 2) Bcl10 polyubiquitinylation, 3) MALT1 protease activation, 4) NF-κB activation, and 5) JNK2 activation. In the presence of co-expressed wild-type CARD11, the LOF variants surprisingly displayed a range of dominant negative activity from strong to intermediate to weak, indicating a specific potency of some mutations to disrupt signaling when heterozygous. Our results suggest that disease-associated dominant negative CARD11 mutations interfere with the Opening Step in the CARD11 signaling cycle and provide a mechanistic basis to explain why some LOF CARD11 mutations can cause disease when heterozygous while others do so when homozygous.
EXAFS and XANES Investigations of CuFe2O4Nanoparticles and CuFe2O4−MO2(M = Sn, Ce) Nanocomposites (2007)

Structural investigations were performed on combustion synthesized CuFe2O4 nanoparticles and CuFe2O4−MO2 (M = Sn, Ce) nanocomposites in different compositions, by means of X-ray absorption fine structure spectroscopy. The studies on CuFe2O4 nanoparticles reveal that the samples have a structure analogous to that of the bulk material, wherein all the copper ions occupy the octahedral sites and the iron ions are distributed between the tetrahedral and octahedral sites. The XAFS investigations on CuFe2O4−SnO2 and CuFe2O4−CeO2 nanocomposites show that the incorporation of the tetravalent metal ions in the spinel lattice does not alter the local structure around copper and iron in CuFe2O4 nanoparticles. The X-ray diffraction pattern indicates CuFe2O4 as a single phase in the nanoparticles and shows the incorporation of metal ions in the spinel structure in addition to the existence of MO2 and CuFe2O4 phases in CuFe2O4−MO2 nanocomposites. The nanometric size of the as-synthesized materials has been confirmed by transmission electron microscopy studies. The high-resolution transmission electron microscopy investigations also confirm that CuFe2O4 exists as a single phase and reveal the composite nature of CuFe2O4−MO2 materials.
Computer vision on tap (2009)

We demonstrate a concept of computer vision as a secure, live service on the Internet. We show a platform to distribute a real time vision algorithm using simple widely available Web technologies, such as Adobe Flash. We allow a user to access this service without downloading an executable or sharing the image stream with anyone. We support developers to publish without distribution complexity. Finally the platform supports user-permitted aggregation of data for computer vision research or analysis. We describe results for a simple distributed motion detection algorithm. We discuss future scenarios for organically extending the horizon of computer vision research.
Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation (2006)

Transection and transplantation of SC/OEG or OEG induced recovery of hindlimb function. This recovered hindlimb movement was sustained in rats housed in MEH but was progressively lost in rats housed in BH. Because benefits of MEH were not observed until 14 weeks after injury, long-term assessment of behavior is recommended. BH conditions are not conducive to maintenance of recovered hindlimb function, and MEH should be used in studies of recovery of function following spinal cord injury.
Nerve growth factor‐mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation‐induced visceral hypersensitivity in rats (2011)

Visceral hyperalgesia is a multifactorial gastrointestinal disorder which featured with alterations of abdominal motility and/or gut sensitivity, and is believed to be triggered by environmental stressor or psychological factors. However, its etiology remains incompletely understood. In this study, we aimed to investigate whether nerve growth factor (NGF)-mediated neuronal plasticity is involved in neonatal maternal separation (NMS)-induced visceral hypersensitivity in adult rats, and whether NGF antagonist can attenuate or block such development. In our experiments, animals subjected to NMS were developed with visceral hyperalgesia at age of 8 weeks. The threshold for visceral pain among these NMS rats was remarkably lowered than that of the normal handling (NH) rats; however, the expression levels of NGF, c-fos, calcitonin gene-related peptide (CGRP), Substance P, and tyrosine kinases A (TrkA) were notably elevated in lumbosacral spinal cord and/or dorsal root ganglion (DRG) when comparing to those of the NH rats. Further, as intra-peritoneal administration of NGF (10 μl at 1 μg/kg/day) was given to NH rats during neonatal period, effects that comparable to NMS induction were observed in the adulthood. In contrast, when NMS rats were treated with NGF antagonist K252a (10 μl/day from postnatal days 2-14), which acts against tyrosine kinases, the neonatal stress-induced down-shifted visceral pain threshold was restored and neuronal activation, specifically NGF and neuropeptide production, was attenuated. In conclusion, our data strongly suggest that NGF triggers neuronal plasticity and plays a crucial role in NMS-induced visceral hypersensitivity in which NGF antagonism provides positive inhibition via blocking the tyrosine phosphorylation of TrkA.
Integrated Approach to Studying the Development and Final Network Properties of Urethane Acrylate Coatings (2006)

An integrated approach, involving the use of a number of analytical techniques, was used to study polymer coating network development during photopolymerization of a series of fast reacting, low modulus coating formulations containing urethane/acrylate oligomers and acrylic comonomers. Real-time UV rheology measurements, to assess the development of viscoelastic properties, and real-time FTIR, to assess the disappearance of acrylic groups, were used to study the early stages of the photocuring reaction up to the gel point. These results showed that the development of the cross-linked network and the rate at which acrylate double bonds reacted were not necessarily directly proportional as might be expected and were dependent upon the structures of the urethane/acrylate oligomer and comonomers comprising a particular coating. Samples of partially polymerized coatings were also prepared having degrees of acrylate conversion ranging from ∼50% through full conversion. Analysis of the amount of extractable material and the molecular weight distribution of soluble oligomeric material as a function of degree of conversion also showed a dependence upon the coating formulation components. In some cases the extraction results for intermediate cure level samples could be correlated to the reactivity trends observed in the early stages of the curing reaction. We also made use of solid-state NMR 1H T2 relaxation measurements to assess both partially and fully reacted films. The rate of magnetization decay correlated well with both the developing level of cross-link density as the degree of polymerization increased and also with the theoretical cross-link densities expected for the fully cured networks based on the structure of the coating formulation components. The latter also correlated well with modulus measurements made on fully cured coating film samples.
Determination of Retinoic Acid-Liposomal Association Level in a Topical Formulation (1994)

A new liposomal formulation containing a lower dose of drug and possessing increased skin bioavailability has recently been proposed. This paper describes a method to quantitatively determine the levels of retinoic acid associated with liposomes in a marketable topical gel.
Negative ion beam requirements for compact tori (1984)

One potential application of negative ion beam sources involves injection into field‐reversed fusion devices for both start‐up and sustainment of plasma currents. High energies provide the prerequisite large orbit ions to drive these currents. A hybrid fluid‐particle computational model is described that has been developed to study injection into a field‐reversed mirror. Comparisons with the earlier experiments (2X‐IIB) at the Lawrence Livermore National Laboratory are encouraging and support the concept of using high‐energy injection in future devices.
Data from Expression Profiles Provide Insights into Early Malignant Potential and Skeletal Abnormalities in Multiple Endocrine Neoplasia Type 2B Syndrome Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Identifying the molecular basis for genotype-phenotype correlations in human diseases has direct implications for understanding the disease process and hence for the identification of potential therapeutic targets. To this end, we performed microarray expression analysis on benign (pheochromocytomas) and malignant (medullary thyroid carcinomas, MTCs) tumors from patients with multiple endocrine neoplasia (MEN) type 2A or 2B, related syndromes that result from distinctive mutations in the &lt;i&gt;RET&lt;/i&gt; receptor tyrosine kinase. Comparisons of MEN 2B and MEN 2A MTCs revealed that genes involved in the process of epithelial to mesenchymal transition, many associated with the tumor growth factor β pathway, were up-regulated in MEN 2B MTCs. This MEN 2B MTC profile may explain the early onset of malignancy in MEN 2B compared with MEN 2A patients. Furthermore, chondromodulin-1, a known regulator of cartilage and bone growth, was expressed at high levels specifically in MEN 2B MTCs. Chondromodulin-1 mRNA and protein expression was localized to the malignant C cells, and its high expression was directly associated with the presence of skeletal abnormalities in MEN 2B patients. These findings provide molecular evidence that associate the previously unexplained skeletal abnormalities and early malignancy in MEN 2B compared with MEN 2A syndrome.&lt;/p&gt;&lt;/div&gt;
Radiolabeling of an anti-carcinoembryonic antigen antibody Fab' fragment (CEA-Scan) with the positron-emitting radionuclide Tc-94m. (1999)

The goal of this work was to test whether an antibody-based agent approved for use as a single-photon-emitting imaging agent when radiolabeled with technetium-99m could be labeled comparably with a positron-emitting nuclide, technetium-94m. "Instant kits" containing lyophilized NP-4 antibody Fab' fragment of an anticarcinoembryonic antigen IgG (CEA-Scan) from the same manufactured lot were reconstituted with either Tc-99m or Tc-94m, as solutions of sodium pertechnetate in isotonic saline solution. Radioanalyses of the labeled Fab' fragments by size-exclusion high-performance chromatography and TLC were carried out. Equivalent results were obtained for radioimmunoconjugates when each was analyzed with both methods. Facile incorporation of Tc-94m into tumor-targeting Fab' antibody fragments will enable investigation of such agents for tumor-specific imaging using positron emission tomography.
Oxidosqualene Cyclase Second‐Sphere Residues Profoundly Influence the Product Profile (2004)

Cycloartenol synthase converts oxidosqualene to the pentacyclic triterpene alcohol cycloartenol. Mutations at His477 dramatically alter the product profile. However, these changes are catalytically irrelevant in the presence of Tyr410Thr and Ile481Val mutations. Modeling studies have established that His477 is a second-sphere residue that affects catalysis indirectly through its interactions with the active-site residue Tyr410.
Millimeter-wave Toroidal Lens-Array Antennas Experimental Measurements (2018)

High gain steerable antennas are the key element of the modern millimeter-wave communication systems: high gain required for overcoming large pathloss in this band, while steering is required for mobile access and reconfigurable backhauling links. In this paper we propose and evaluate the toroidal lens-array antenna (LAA) design, which provide high gain by focusing the beam in elevation plane, while beamsteering can be done in the azimuthal plane. Three LAA systems of different size demonstrated reliable multi-gigabit link at distances 100-300m. The further gain (and aperture) increase of LAAs limited mainly by the lens size and weight.
New Route to Smart Core‐Shell Polymeric Microgels: Synthesis and Properties (2004)

Abstract Summary: A new method has been developed to prepare smart polymeric microgels that consist of well‐defined temperature‐sensitive cores with pH‐sensitive shells. The microgels were obtained directly from aqueous graft copolymerizations of N ‐isopropylacrylamide and N , N‐ methylenebisacrylamide from water‐soluble polymers containing amino groups such as poly(ethyleneimine) and chitosan. The gel diameters ranged from 300 to 400 nm. The unique core‐shell nanostructures, which had narrow size distributions, exhibited tuneable responses to pH and temperature. Transmission electron micrograph of the poly( N ‐isopropylacrylamide)/chitosan core‐shell microgels. image Transmission electron micrograph of the poly( N ‐isopropylacrylamide)/chitosan core‐shell microgels.
Deep Shutter Unrolling Network (2020)

We present a novel network for rolling shutter effect correction. Our network takes two consecutive rolling shutter images and estimates the corresponding global shutter image of the latest frame. The dense displacement field from a rolling shutter image to its corresponding global shutter image is estimated via a motion estimation network. The learned feature representation of a rolling shutter image is then warped, via the displacement field, to its global shutter representation by a differentiable forward warping block. An image decoder recovers the global shutter image based on the warped feature representation. Our network can be trained end-to-end and only requires the global shutter image for supervision. Since there is no public dataset available, we also propose two large datasets: the Carla-RS dataset and the Fastec-RS dataset. Experimental results demonstrate that our network outperforms the state-of-the-art methods. We make both our code and datasets available at https://github.com/ethliup/DeepUnrollNet.
Cavity enhanced on-chip spectrometer with sub-nm resolution (2010)

A novel on-chip spectrometer device using combined functionalities of a micro-ring resonator and a planar diffraction grating is proposed and demonstrated. The spectrometer has a 2 mm2 footprint and exhibits 100 channels each with 0.05 nm FWHM.
Immunoscintigraphy with131I-labelled HMFG2 and HMFG2 F(ab')2 in the pre-operative detection of clinical and subclinical lymph node metastases in breast cancer patients (1988)

Radiolabelled specific monoclonal antibodies (MAbs) HMFG2 and HMFG1 F(ab')2 and non-specific 11.4.1 and 4C4 F(ab')2 were injected into the webs between the 2nd and 3rd fingers of both hands in 31 patients with clinical diagnosis of breast cancer. We studied 10 patients with clinically obvious axillary lymph-node disease (group A) and 10 patients with clinically negative axilla (group B) using HMFG2, 5 patients with clinically negative axilla (group C) using HMFG1 F(ab')2 and 6 patients with clinically positive axilla (group D) using non-specific 11.4.1 and 4C4 F(ab')2 MAbs. In group A, 7 patients had true positive scans. There were also 3 false negative scans, due to problems related to proper iodination at the beginning of this study. In group B there were 4 true positive scans, 4 true negative, I false positive and I false negative. In group C there were 4 true negative scans. In one patient the radiolabelled antibody was arrested in the middle of the arm, because of lymphatic obstruction. In group D, there were 3 false negative scans with 11.4.1 antibody and 3 false negative scans with 4C4 F(ab')2 MAb. The results of immunoscintigraphy were in accordance with the histopathology and immunoperoxidase staining findings. These results indicate that this non-invasive approach can accurately detect metastatic involvement in the axillary lymph nodes and can be used for the diagnosis and staging of breast cancer.
Modeling the Error of the Medtronic Paradigm Veo Enlite Glucose Sensor (2017)

Continuous glucose monitors (CGMs) are prone to inaccuracy due to time lags, sensor drift, calibration errors, and measurement noise. The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas studies (G4AP) systems. An enhanced methodology to a previously employed technique was utilized to dissect the sensor error into several components. The dataset used included 37 inpatient sessions in 10 subjects with type 1 diabetes (T1D), in which CGMs were worn in parallel and blood glucose (BG) samples were analyzed every 15 ± 5 min Calibration error and sensor drift of the ENL sensor was best described by a linear relationship related to the gain and offset. The mean time lag estimated by the model is 9.4 ± 6.5 min. The overall average mean absolute relative difference (MARD) of the ENL sensor was 11.68 ± 5.07% Calibration error had the highest contribution to total error in the ENL sensor. This was also reported in the 7P, G4P, and G4AP. The model of the ENL sensor error will be useful to test the in silico performance of CGM-based applications, i.e., the artificial pancreas, employing this kind of sensor.
Transcriptional and epigenetic regulation of lung development and regeneration (2012)

Development of the respiratory system is controlled by a myriad of transcription factors and signaling pathways that interact to regulate various aspects of cell differentiation. The result is a highly organized system of airways closely aligned with the pulmonary vasculature that is required for postnatal respiration. How these transcription factors and signaling pathways interact to promote cell lineage fate and differentiation is poorly understood but likely involves epigenetic mechanisms. Our lab has recently focused on epigenetic mechanisms that regulate cell differentiation in the developing and regenerating lung. Published and unpublished data from our lab support important roles for miRNAs and HDAC mediated mechanisms that drive cell type differentiation in a spatial and temporal specific fashion in the developing lung. Moreover, some of these pathways play critical roles in lung regeneration and may provide important new therapeutic targets for human lung disease.
Deep Neural Network Based Optical Monitor Providing Self-Confidence as Auxiliary Output (2018)

We present a deep-learning-based optical monitor that simultaneously outputs an optical signal-to-noise ratio and its confidence level using a dropout technique at inference time. Its behaviour is analysed with partially missing and limited number of records in training dataset.