gebhart/patrepeval huggingface dataset:
Backup and process migration mechanisms in process support systems (1998)

Availability in Process Support Systems (PSS) can be achieved by using standby mechanisms that allow a backup server to take over in case a primary server fails. These mechanisms, resembling the process pair approach used in operating systems, require the primary to send information about state changes to the backup on a regular basis. In PSS where all relevant state information is stored in a database, there are two principal strategies for synchronizing a primary–backup pair. One is to use the replication mechanisms provided by the DBMS. Another is to implement a message mechanism to ex change state information between servers above the database level. For both approaches, several variants exist that allow to trade run-time performance for failover time. This paper discusses the possible strate gies and evaluates their performance based on an implementation within the OPERA process support kernel. Moreover, it is shown how the mechanisms can be used as the basis for implementing process migration in a distributed setting.
Conditioned Immunity to L. Major in Young and Aged Mice (2020)

Resistance to infection essentially can be described as being of two types, innate and acquired, dependent upon activation of host immunity with secondary enhanced killing of amastigotes within infected cells. Macrophage function has also been shown to be diminished in stressed animals; the decreased MHC class II antigen expression on macrophages in these models in turn leads to impaired antigen-presenting-function, decreased lymphocyte activation, and thus decreased immunity to infection. Investigations of possible biochemical mechanisms behind the phenomenon of conditioning of immune responses, or stress-induced alteration of immunity, are rare. In a conditioning model in which mice were exposed to physical stressors, along with a number of environmental cues associated with that stressor, it was found subsequently that mere exposure to the cues at the same time as the animals received an immunological challenge would produce documented inhibition of the immune response when compared with non-stressed animals, or animals stressed but not re-exposed to the cues.
A Review of Model-Based Prognostic for Proton Exchange Membrane Fuel Cell under Automotive Load Cycling (2019)

Low durability issue of Proton Exchange Membrane Fuel Cell (PEMFC) under Automotive Load Cycling (ALC) can be tackled by applying model-based prognostic. Model-based methods allow predicting the Remaining Useful Life (RUL) of the system in order to apply preventive maintenance actions. These methods build a degradation model, which can be empirical or physical-based, and use the model to describe the PEMFC aging. This paper presents a review of model-based methods for PEMFC prognostic under ALC. Moreover, the current limitations of the proposed methods, the presented degradation models and the prediction horizon are discussed.
Immuno‐Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet‐Cleavable Mass Tags (2023)

Abstract We present immunoassay‐based desorption electrospray ionization mass spectrometry imaging (immuno‐DESI‐MSI) to visualize functional macromolecules such as drug targets and cascade signaling factors. A set of boronic acid mass tags (BMTs) were synthesized to label antibodies as MSI probes. The boronic ester bond is employed to cross‐link the BMT with the galactosamine‐modified antibody. The BMT can be released from its tethered antibody by ultrafast cleavage of the boronic ester bond caused by the acidic condition of sprayed DESI microdroplets containing water. The fluorescent moiety enables the BMT to work in both optical and MS imaging modes. The positively charged quaternary ammonium group enhances the ionization efficiency. The introduction of the boron element also makes mass tags readily identified because of its unique isotope pattern. Immuno‐DESI‐MSI provides an appealing strategy to spatially map macromolecules beyond what can be observed by conventional DESI‐MSI, provided antibodies are available to the targeted molecules of interest.
<i>In Situ</i> Synchrotron X-ray Analysis: Application of High-Pressure Sliding Process to Ti Allotropic Transformation (2020)

In this study, severe plastic deformation through high-pressure sliding (HPS) was applied for in situ high-energy X-ray diffraction analysis at SPring-8 in JASRI (Japan Synchrotron Radiation Research Institute). Allotropic transformation of pure Ti was examined in terms of temperatures, pressures and imposed strain using a miniaturized HPS facility. The true pressure applied on the sample was estimated from the peak shift. Peak broadening due to local variation of pressure was reduced using white X-rays. The phase transformation from α phase to ω phase occurred at a pressure of ∼4.5 GPa. Straining by the HPS processing was effective to promote the transformation to the ω phase and to maintain the ω phase even at ambient pressure. The reverse transformation from ω phase to α phase occurred at a temperature of ∼110°C under ambient pressure, while under higher pressure as ∼4 GPa, the ω phase remained stable even at ∼170°C covered in this study. It was suggested that the reverse transformation from the ω phase to the α phase is controlled by thermal energy.
Frequent walking, but not total physical activity, is associated with increased fracture incidence: A 5-year follow-up of an Australian population-based prospective study (AusDiab) (2011)

Current public health physical activity (PA) guidelines recommend that older adults accumulate ≥ 2.5 hours per week of moderate- to vigorous-intensity PA to optimize health. The aim of this study was to examine (1) whether adults who meet the current PA guidelines are at reduced risk of fracture, (2) whether fracture risk varies by PA type/intensity and frequency, and (3) whether prolonged TV viewing, as a marker of sedentary behavior, is associated with fracture risk. This national, population-based prospective study with a 5-year follow-up included 2780 postmenopausal women and 2129 men aged 50 years or older. Incident nontraumatic clinical fractures were self-reported. Overall, 307 (6.3%) participants sustained at least one incident low-trauma fracture (women 9.3%, men 2.3%). Multivariate logistic regression, adjusting for age, body mass index (BMI), physical function, previous fracture history, smoking, and dietary calcium and serum 25-hydroxyvitamin D levels, showed that women who walked more than 3 hours per week or completed at least 6 weekly bouts of walking had a 51% and 56% increased fracture risk, respectively, compared with women who did no walking [odds ratio (OR) time = 1.51, 95% confidence interval (CI) 1.01-2.24; OR frequency = 1.56, 95% CI 1.07-2.27]. However, total and moderate to vigorous PA time and the accumulation of 2.5 hours per week or more of PA and TV viewing time were not associated with incident fractures. In men, there also was an increased fracture risk for those who walked more than 3 hours per week (OR = 2.30, 95% CI 1.06-4.97) compared with those who reported no walking. In conclusion, older adults who adhered to the current PA guidelines were not protected against fragility fractures, but more frequent walking was associated with an increased fracture risk.
Automatic registration of pelvic computed tomography data and magnetic resonance scans including a full circle method for quantitative accuracy evaluation (1998)

The purpose of this study is to develop a method for registration of CT and MR scans of the pelvis with minimal user interaction and to obtain a means for objective quantification of the registration accuracy of clinical data without markers. CT scans were registered with proton density MR scans using chamfer matching on automatically segmented bone. A fixed threshold was used to segment CT, while morphological filters were used to segment MR. The method was tested with transverse and coronal MR scans of 18 patients and sagittal MR scans of 8 patients. The registration accuracy was estimated by comparing (triangulating) registrations of a single CT scan with MR in different orientations in a "full circle." For example, CT is first matched on transverse MR, next transverse MR is matched independently on coronal MR, and finally coronal MR is matched independently on CT. The product of the three transformations is the identity if all matching steps are perfect. Deviations from identity occur both due to random errors and due to some types of systematic errors. MR was registered on MR (to close the "circle") by minimization of rms voxel value differences. CT-MR registration takes about 1 min, including user interaction. The random error for CT-MR registration with transverse or coronal MR was 0.5 mm in translation and 0.4 degree in rotation (standard deviation) for each axis. A systematic registration error of about 1 mm was demonstrated along the MR frequency encoding direction, which is attributed to the chemical shift. In conclusion, the presented algorithm efficiently and accurately registers pelvic CT and MR scans on bone. The "full circle" method provides an estimate of the registration accuracy on clinical data.
Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease (2019)

Cervical screening by high-risk HPV (hrHPV) testing requires additional risk stratification (triage), as most infections are transient and only a subset of hrHPV-positive women harbours clinically relevant disease. Molecular triage markers such as microRNAs (miRNAs) and DNA methylation markers are particularly promising, as they can be objectively tested directly on hrHPV-positive scrapes and cervicovaginal self-samples. Here, we evaluated the marker potential of 10 candidate miRNAs in 209 hrHPV-positive scrapes of women with underlying precancer (cervical intraepithelial neoplasia, grade 2-3 (CIN2-3)), cancer, or without disease (CIN0/1). A predictive miRNA classifier for CIN3 detection was built using logistic regression, which was compared to and combined with DNA methylation marker <i>FAM19A4</i>. Markers were correlated to histology parameters and hrHPV genotype. A miRNA classifier consisting of miR-149, miR-20a, and miR-93 achieved an area under the curve (AUC) of 0.834 for CIN3 detection, which was not significantly different to that of <i>FAM19A4</i> methylation (AUC: 0.862, p = 0.591). Combining miRNA and methylation analysis demonstrated complementarity between both marker types (AUC: 0.939). While the miRNA classifier seemed more predictive for CIN2, <i>FAM19A4</i> methylation was particularly high in HPV16-positive and histologically advanced CIN3, i.e. CIN3 with high lesion volume. The miRNA classifier, <i>FAM19A4</i> methylation, and the miRNA/methylation combination were highest in cancer-associated scrapes. In conclusion, a panel of three miRNAs is discriminatory for CIN3 in hrHPV-positive scrapes and can complement DNA methylation analysis for the efficient detection of cervical disease. Combined analysis of the two marker types warrants further evaluation as triage strategy in hrHPV-based screening.
Quantification and coupling of the electromagnetic and chemical contributions in surface-enhanced Raman scattering (2019)

In surface-enhanced Raman scattering (SERS), both chemical (CE) and electromagnetic (EM) field effects contribute to its overall enhancement. However, neither the quantification of their relative contributions nor the substrate dependence of the chemical effect have been well established. Moreover, there is to date no understanding of a possible coupling between both effects. Here we demonstrate how systematically engineered silver and gold planar and nanostructured substrates, covering a wide range of field enhancements, provide a way to determine relative contributions of chemical and electromagnetic field-enhancement in SERS measurements of benzenethiol. We find a chemical enhancement of 2 to 14 for different vibrational resonances when referencing against a vibrational mode that undergoes minimal CE. The values are independent of substrate type and independent of the enhancement of the electromagnetic intensity in the range from 1 to 10<sup>6</sup>. This absence of correlation between chemical and electromagnetic enhancement resolves several long-standing controversies on substrate and intensity dependence of the chemical enhancement and allows for a more systematic design of SERS substrates with desired properties.
On isolation, concurrency, and the Venus rule language (1995)

Article On isolation, concurrency, and the Venus rule language Share on Authors: Stephen Correl Department of Computer Sciences and the Applied Research Laboratories, University of Texas at Austin, Austin, Texas Department of Computer Sciences and the Applied Research Laboratories, University of Texas at Austin, Austin, TexasView Profile , Daniel P. Miranker Department of Computer Sciences and the Applied Research Laboratories, University of Texas at Austin, Austin, Texas Department of Computer Sciences and the Applied Research Laboratories, University of Texas at Austin, Austin, TexasView Profile Authors Info & Claims CIKM '95: Proceedings of the fourth international conference on Information and knowledge managementDecember 1995 Pages 281–289https://doi.org/10.1145/221270.221591Published:02 December 1995 5citation213DownloadsMetricsTotal Citations5Total Downloads213Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
18F-Branched-Chain Amino Acids: Structure–Activity Relationships and PET Imaging Potential (2019)

The large, neutral L-type amino acid transporters (LAT1-LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT expression levels are increased in many types of cancer, and their expression increases as cancers progress, leading to high expression levels in high-grade tumors and metastases. Because of the key role and overexpression of LAT in many types of cancer, radiolabeled LAT substrates are promising candidates for nuclear imaging of malignancies that are not well revealed by conventional radiotracers. The goal of this study was to examine the structure-activity relationships of a series of <sup>18</sup>F-labeled amino acids that were predicted to be substrates of the LAT transport system. <b>Methods:</b> Using a photocatalytic radical fluorination, we prepared a series of 11 fluorinated branched-chain amino acids and evaluated them and their nonfluorinated parents in a cell-based LAT affinity assay. We radiofluorinated selected branched-chain amino acids via the same radical fluorination reaction and evaluated tumor uptake in U-87 glioma xenograft-bearing mice. <b>Results:</b> Structure-activity relationship trends observed in a LAT affinity assay were maintained in further <i>in vitro</i> studies, as well as <i>in vivo</i> using a U-87 xenograft model. LAT1 uptake was tolerant of fluorinated amino acid stereochemistry and chain length. PET imaging and biodistribution studies showed that the tracer (<i>S</i>)-5-<sup>18</sup>F-fluorohomoleucine had rapid tumor uptake, favorable <i>in vivo</i> kinetics, and good stability. <b>Conclusion:</b> By using an <i>in vitro</i> affinity assay, we could predict LAT-mediated cancer cell uptake in a panel of fluorinated amino acids. These predictions were consistent when applied to different cell lines and murine tumor models, and several new tracers may be suitable for further development as oncologic PET imaging agents.
Recognition of 1997 TRANSACTIONS Papers Reviewers (1998)

The publication offers a note of thanks and lists its reviewers.
Identification and prevalence of swine pasivirus 1 in eastern Romanian pig farms (2017)

Swine pasivirus 1 (SPaV-1) was first detected in the feces of healthy pigs in France as a new species in family Picornaviridae. We investigated the presence, distribution, and genetic variability of this virus in 7 geographic areas with intensive pig breeding farms in eastern Romania. A total of 564 porcine specimens, including 82 fecal specimens and 482 pools of organs, were collected from healthy pigs in different stages of production from pathogen-free swine farming units. The virus was found in 6 of 7 areas investigated. Of the 564 samples analyzed, 218 were positive for SPaV-1, with the highest prevalence of the virus in organ homogenates (39% positive) followed by feces (37% positive). The highest susceptibility to infection was found in nurseries (50% positive in both the first and second months of feeding). Sequencing analysis of VP0 revealed 3 different Romanian sequences. The phylogenetic investigations suggest that the Romanian sequences cluster with other Pasivirus strains selected from the GenBank database, forming a separate clade from other Picornaviridae genera and defining the described Pasivirus.
Growth of uropathogenic Escherichia coli strains at solid surfaces (1992)

The adhesion and growth of two catheter-associated (O2K2 and O83K?) and two non catheter-associated (O111K58 and O157K-) uropathogenic Escherichia coli strains on glass, poly(methyl methacrylate) (PMMA), a negatively charged copolymer of MMA and methacrylic acid (MAA) and a positively charged copolymer of MMA and trimethylaminoethyl methacrylate chloride (TMAEMA-Cl) were studied. The solid surfaces were placed in a parallel plate perfusion system. After preadhesion of the bacteria onto the surfaces, growth was initiated by perfusing the system with MacConkey broth. Growth was measured by counting adherent bacteria as a function of time. Bacterial strains were characterized by means of water contact angle, microbial adhesion to hydrocarbon (MATH), anion exchange resin retention (ARR) and zeta potential measurements. Solid surfaces were characterized by means of water contact angle and zeta potential measurements. The catheter-associated strains had significantly higher water contact angles, zeta potentials and ARR values than the non catheter-associated strains. Non catheter-associated strains did not grow at the surfaces used. Catheter-associated strains did not grow at the positively charged surface but exhibited growth at the other surfaces. Strains grew more rapidly at surfaces with a relatively high negative zeta potential and a low water contact angle than at surfaces with a relatively low negative zeta potential and a high water contact angle. The growth of strain O2K2 on glass was significantly reduced when urine instead of MacConkey broth was used as perfusion medium.
TrackPad: Software for semi-automated single-cell tracking and lineage annotation (2020)

TrackPad is an open-source, biologist-friendly, graphical user interface for tracking and annotating single-cell lineage fates from time-lapse movies. The software applies cross-correlative, template-matching (CCTM) to track each cell using transmitted or fluorescent images. Machine tracking is supervised by the investigator, who can manually annotate cell fates such as division, death, or changes in cell phenotype. Search parameters that minimise user interventions and tracking time are selected by simulating tracking using verified tracking data as a ground truth. Investigators who use this software can produce high-quality annotated cell trajectories and division pedigrees to understand how intrinsic and extrinsic factors influence cell states and fates.
Influenza Virus Infection in Guinea Pigs Raised as Livestock, Ecuador (2012)

To determine whether guinea pigs are infected with influenza virus in nature, we conducted a serologic study in domestic guinea pigs in Ecuador. Detection of antibodies against influenza A and B raises the question about the role of guinea pigs in the ecology and epidemiology of influenza virus in the region.
Flexible reflective and emissive display integration and manufacturing (Invited Paper) (2005)

The U.S. Army, Arizona State University (ASU) and commercial industry have joined forces to create the Flexible Display Center (FDC) at Arizona State University, a large-scale collaborative venture designed to rapidly advance flexible display technology to the brink of commercialization. The Center has completed its startup phase and is now engaged in an intensive and aggressive applied research and development program that will produce high quality, high performance active matrix reflective and emissive flexible display technology demonstrators (TDs). Electrophoretic ink and cholesteric liquid crystals have been selected as Center reflective imaging layer technologies; these technologies are attractive because they are fully reflective and bistable (extremely low power) and because the materials are environmentally robust and intrinsically rugged. Organic light emitting devices (OLEDs) have been chosen as the emissive imaging layer technology. These three electro-optic subsystems will be integrated with a flexible a-Si thin film transistor active matrix backplane platform. We have created the integrated design, backplane fabrication, display assembly, test and evaluation capability to enable rapid cycles of learning and technology development. Backplane fabrication is currently accomplished on a 6” wafer scale pilot line linked to a Manufacturing Execution System and supported by a comprehensive suite of in-fab metrology tools. We are currently installing a GEN II pilot line, with qualified operation slated for 2006. This line will be used to demonstrate process and display form factor capability, while providing high yield low volume manufacturing of pilot-scale levels of technology demonstrators for the Army and our commercial partners.
Operational Regimes in Picosecond and Femtosecond Pulse-Excited Ultrahigh Vacuum SERS (2016)

We report a systematic study performed in ultrahigh vacuum designed to identify the laser excitation regimes in which plasmonically enhanced ultrashort pulses may be used to nondestructively probe surface-bound molecules. A nondestructive, continuous-wave spectroscopic probe is used to monitor the effects of four different femtosecond- and picosecond-pulsed beams on the SER signals emanating from molecular analytes residing within plasmonically enhanced fields. We identify the roles of plasmonic amplification and alignment with a molecular electronic transition on the observed changes in the SER signals. Our results indicate that overlap of the laser wavelength with the plasmon resonance is the dominant contributor to signal degradation. In addition, signal loss for a given irradiation condition is observed only for molecules residing in hot spots above a threshold enhancement. Identification of suitable laser energy density ranges demonstrates the importance of considering these parameters when implementing SERS in the presence of pulsed irradiation.
On Design Patterns for Sensor Networks (2007)

A design pattern is a general solution to a commonly occurring problem. Design patterns have proven highly effective in representing, transferring, and applying the design knowledge in many engineering disciplines. However, these patterns have not addressed sensor network specifically. With a growth of sensors and sensor networks, and considering their profound applicability, there is a crucial need to articulate ones experience of application development or deployment of sensor nodes in the form of design patterns to avoid the future mistakes. This paper discusses the same issue and show applicability of design patterns in sensor networks. 1.