gebhart/patrepeval huggingface dataset:
THE ANALYSIS OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN HYPERTROPHIC CARDIOMYOPATHY (2012)

Objectives To observe the correlation between inflammatory factor monocyte chemotactic protein -1 and high sensitivity C-reactive protein (hs-CRP) in hypertrophic cardiomyopathy (HCM) patients. Methods 286 cases of patients with HCM were selected from two hospitals from January 2005 to December 2010. HCM diagnostic criteria in accordance with the ACC/ESC expert consensus hypertrophic cardiomyopathy (2003). Records of all patients age, sex, medical history, NYHA classification of cardiac function, the main indicators of ECG and echocardiography to exclude diabetes, infectious diseases, cancer, collagen diseases, application of immunosuppressive drugs. The contents of MCP-1 and hs-CRP in all patients were determined by ELISA. Results The median value of MCP-1 of 286 patients was 370.28 ng/l (157.21±439.47 ng/l); hs-CRP median value was 1.97 mg/l (1.12±2.75 mg/l), two indicators were higher than normal. 89 cases (31.1%) underwent coronary angiography showed that 21 cases (7.3%) had coronary heart disease, these patients and those without coronary heart disease had no statistically significant difference between the two indicators. The levels of MCP-1 and hs-CRP increased associated with the largest increase in wall thickness (p&lt;0.05); significant T-wave inversion (p&lt;0.01); chest pain or syncope symptoms (p&lt;0.05). Conclusions HCM may be associated with the inflammatory response, particularly in those patients with wall thickening, significantly T wave changes, chest pain or syncope symptoms.
Facility Level Energy and Cost Analyses for Water Cooled Supercomputer Systems (2009)

This paper describes the facility level design of future water cooled supercomputers with an emphasis on the energy efficiency opportunities related to the use of water cooled economizer based facility cooling in lieu of traditional refrigeration chiller architectures. A hybrid cooled 80kW server rack with both air and water cooled components is considered for the analyses. In this system, 90% of the rack heat load is rejected directly to pumped water lines via CPU cold plates and conduction cooling and the remaining 10% rack power is rejected to the room ambient air and is subsequently transferred to the water loop via air to liquid heat exchanger based devices. Air to water heat exchangers are not included in the server racks. The facilities cost for water cooling of high power computer racks has been analyzed for data centers situated in two different geographic locations. The study takes into account both the energy savings resulting from the loop design as well as the duration of time for which these savings can be realized at the selected locations. Test data for the water cooled CPU modules is used to project the maximum chip junction temperature for different chilled water temperatures which are in turn determined using the outdoor air temperatures for different times of the year. After calculating the 5 year energy consumption savings over the traditional plant design for each location, for the two different geographic locations in the US considered, it was found that the outdoor weather permitted the use of the economizer based configuration for 53–76% and 60–80% of the time for A and B locations, respectively, yielding per rack energy related savings of $6–21k and $17–26k, respectively, for the thermal conditions considered.
Thin n -GaN films with low level of 1/ f noise (2001)

The authors report on the results of measurements of low frequency noise in thin (60 nm) Si-doped n-type gallium nitride (GaN) films grown on sapphire. At room temperature, the noise spectra have the form of 1/f noise with a Hooge parameter α ~ 2 × 10-3. This value of α is three orders of magnitude smaller than that observed before in thin films of n-GaN.
The Security and Performance of the Galois/Counter Mode of Operation (Full Version). (2004)

The recently introduced Galois/Counter Mode (GCM) of operation for block ciphers provides both encryption and message authentication, using universal hashing based on multiplication in a binary finite field. We analyze its security and performance, and show that it is the most efficient mode of operation for high speed packet networks, by using a realistic model of a network crypto module and empirical data from studies of Internet traffic in conjunction with software experiments and hardware designs. GCM has several useful features: it can accept IVs of arbitrary length, can act as a stand-alone message authentication code (MAC), and can be used as an incremental MAC. We show that GCM is secure in the standard model of concrete security, even when these features are used. We also consider several of its important system-security aspects.
Biological Methods for Cell-Cycle Synchronization of Mammalian Cells (2001)

Understanding the molecular and biochemical basis of cellular growth and division involves the investigation of regulatory events that most often occur in a cell-cycle phase-dependent fashion. Studies examining cell-cycle regulatory mechanisms and progression invariably require cell-cycle synchronization of cell populations. Thus, many methods have been established to synchronize cells at specific phases of the cell cycle. Several of the common methods involve pharmacological agents, which act at various points throughout the cell cycle. Because of adverse cellular perturbations resulting from many of the synchronizing drugs used, other synchrony methods that involve less perturbation of biological systems, such as serum deprivation, contact inhibition, and centrifugal elutriation have a significant advantage. The advantages and disadvantages of these cell synchronization methods are discussed in this review.
Cisco Multiservice Switching Networks (2002)

From the Publisher:
A practical guide to understanding Cisco's multiservice switching architecture and designing and deploying MPLS and PNNI implementations

Learn theory framework and configuration of MSS and design guidelines. Includes a case study with MPLS and PNNI in all the platforms. The only book regarding Multiservice Switching architecture and configuration which provides hard-to-find information to readers. Includes consolidated information/examples about MPLS and PNNI in MSS.


Service providers and enterprise customers are faced with the objective of delivering different services over a common infrastructure so that they don't interfere among each other. This can be achieved through the use of Cisco Multiservice Switched Networks. The objective of Cisco Multiservice Switching Networks is to shed light on the general architecture of MSS and presents the cases of MPLS, PNNI and both protocols running independently in MSS Networks. This will aid design, deployment and troubleshooting of networks that use BPX/IGX/MGX families of MS Switches. Cisco Multiservice Switching Networks covers the architecture of Multiservice Switches in which one or more controllers are attached to the 'controlled switch' acting like 'Ships in the Night'. Specific details about MPLS and PNNI implementations are discussed, finishing with a complete MSS case study.

Carlos Pignataro, CCIE #4619, is an Escalation Engineer with Cisco Systems.
Ross Kazemi, CCIE #2742, is a support engineer in all categories, Design Implementation and troubleshooting for Cisco Systems. 
Bill Dry, CCIE #4191, is a Solutions Support Engineer with CiscoSystems, supporting the Cisco Access, WAN and WAN Switching product lines.
Creep Modeling for Injection-Molded Long-Fiber Thermoplastics (2008)

This paper proposes a model to predict the creep response of injection-molded long-fiber thermoplastics (LFTs). The model accounts for elastic fibers embedded in a thermoplastic resin that exhibits the nonlinear viscoelastic behavior described by the Schapery’s model. It also accounts for fiber length and orientation distributions in the composite formed by the injection-molding process. Fiber length and orientation distributions were measured and used in the analysis that applies the Eshelby’s equivalent inclusion method, the Mori-Tanaka assumption (termed the Eshelby-Mori-Tanaka approach) and the fiber orientation averaging technique to compute the overall strain increment resulting from an overall constant applied stress during a given time increment. The creep model for LFTs has been implemented in the ABAQUS finite element code via user-subroutines and has been validated against the experimental creep data obtained for long-glass-fiber/polypropylene specimens. The effects of fiber orientation and length distributions on the composite creep response are determined and discussed.
Adhesion between template materials and UV-cured nanoimprint resists (2007)

Defects in polymeric lithographic stencils fabricated by the UV-cured nanoimprint technique result from fundamental surface interactions between template and resist in addition to the presence of particles and contaminants. Repeated and molecularly clean separations of the template from the cured resist are a requirement for successful application of the imprint method yet little is understood about their dependence on interfacial physics and chemistry. The process of interfacial separation of several model acrylate nanoimprint resist formulations cured in contact with clean (no release treatment) and release-treated silica glass surfaces has been quantitatively investigated. The results show that interfacial fracture energies are resist formulation dependent, that the resist-release layer systems studied are not chemically stable and that the release process is more complex than simple fracture at a glass-organic interface.
Continuous Flow Synthesis and Purification of Aryldiazomethanes through Hydrazone Fragmentation (2016)

Abstract Electron‐rich diazo compounds, such as aryldiazomethanes, are powerful reagents for the synthesis of complex structures, but the risks associated with their toxicity and instability often limit their use. Flow chemistry techniques make these issues avoidable, as the hazardous intermediate can be used as it is produced, avoiding accumulation and handling. Unfortunately, the produced stream is often contaminated with other reagents and by‐products, making it incompatible with many applications, especially in catalysis. Herein is reported a metal‐free continuous flow method for the production of aryldiazomethane solutions in a non‐coordinating solvent from easily prepared, bench‐stable sulfonylhydrazones. All by‐products are removed by an in‐line aqueous wash, leaving a clean, base‐free diazo stream. Three successful sensitive metal‐catalyzed transformations demonstrated the value of the method.
Comparative Study of Magnetic Ordering in Bulk and Nano-Grained La$_{0.4}$Ca$_{0.6}$MnO$_{3}$ Manganite (2008)

To explore the size effect in electron-doped La <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.4</sub> Ca <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</sub> MnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LCMO) compound, dc magnetic measurements and electron magnetic resonance were carried out with bulk and nano-grained LCMO in temperature ranges 5 K les T les 350 K and 5 K les T les 600 K, respectively. It appears that the antiferromagnetic, charge ordered state remains stable upon the reduction of the samples size down to nanometer scale. However, the low-temperature ferromagnetic (FM) component enhances in nano-grained LCMO as compared to its bulk counterpart, supposedly due to strong surface and inter-grain interaction effects. FM correlations in bulk and nano crystals are strong at paramagnetic (PM) state, which seems to be an electron-doping effect. The domination of ion-ion spin relaxation mechanism in PM state and drastic fading of the FM correlations upon cooling means that the doped electrons are localized in both bulk and nano-grained LCMO. The notable influence of the oxygen stoichiometry on magnetic ordering in LCMO, revealed in this work, may explain the contradictive data on the magnetic state of nano-crystalline LCMO reported in the literature.
Three dimensional strain distribution of wrinkled silicon nanomembranes fabricated by rolling-transfer technique (2013)

This paper introduces a simple transfer technique named as rolling-transfer technology to transfer Si nanomembranes to pre-stressed elastomers with nearly 100% transfer efficiency. When transferred onto the elastomeric substrate, wave-like wrinkled Si nanomembranes with uniform periodicity and amplitude are formed. The three dimensional (3-D) strain distribution of the wrinkled Si nanomembranes has been investigated in detail through the micro-Raman mapping using two excited laser wavelengths. The sinusoidal bulking geometry of Si nanomembrane results in a periodical strain alternation along x direction, while a homogenous strain distribution in y direction. The inhomogeneous strain distribution along z direction can be interpreted with the physical model considering the shift of the neutral mechanical plane, which is qualitatively determined by the Von Karman elastic nonlinear plate theory, including the bending effect and the shear forces existing at the Si nanomembrane/elastomeric substrate interface.
Supplemental Table 3 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor (2023)

&lt;p&gt;JNJ-42756493 anti-proliferative activity against cancer cells lines from multiple origins.. Detailed data supporting Figure 2.&lt;/p&gt;
Secured Routines: Language-based Construction of Trusted Execution Environments (2019)

Trusted Execution Environments (TEEs), such as Intel SGX enclaves, use hardware to ensure the confidentiality and integrity of operations on sensitive data. While the technology is available on many processors, the complexity of its programming model and its performance overhead have limited adoption. TEEs provide a new and valuable hardware functionality that has no obvious analogue in programming languages, which means that developers must manually partition their application into trusted and untrusted components. This paper describes an approach that fully integrates trusted execution into a language. We extend the Go language to allow a programmer to execute a goroutine within an enclave, to use low-overhead channels to communicate between the trusted and untrusted environments, and to rely on a compiler to automatically extract the secure code and data. Our prototype compiler and runtime, GOTEE, is a backward-compatible fork of the Go compiler. The evaluation shows that our compiler-driven code and data partitioning efficiently executes both microbenchmarks and applications. On the former, GOTEE achieves a 5.2×throughput and a 2.3× latency improvement over the Intel SGX SDK. Our case studies, a Go ssh server, the Go tls package, and a secured keystore inspired by the go-ethereum project, demonstrate that minor source-code modifications suffice to provide confidentiality and integrity guarantees with only moderate performance overheads.
Simulations of magnetized capacitively coupled plasmas operating at constant power and voltage (2005)

The impact of frequency, magnetic field and secondary electron emission on the characteristics of a magnetized capacitively coupled Ar/C2F6 plasma operating at constant power is investigated. The plasma characteristics at constant power are also compared to corresponding results for constant voltage operation. Some plasma characteristics behave similarly in the two modes of operation. For example, charged species densities increase as a function of frequency in both modes. However, unlike for constant voltage operation, charged and neutral species densities decrease with the application of a magnetic field in the constant power mode at high frequencies and at sufficiently large magnetic fields. This uncharacteristic behaviour is attributed to a substantial increase in negative ion power consumption in Ar/C2F6 when a strong magnetic field is applied. Application of the magnetic field decreases electron mobility towards the sheaths, which increases the participation of negative ions in sheath and pre-sheath dynamics. Negative ions consequently shift closer to the electrodes, negative ion power consumption increases substantially, and relatively less power is left for the electrons. Lower electron power results in the production of less charged and neutral species through electron impact processes. Simulations in Ar confirm that, without the negative ions, charged and neutral species densities increase with the application of a magnetic field at constant power. Also, for small magnetic fields, species densities increase with the magnetic field even in electronegative plasma discharges.
Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction (2020)

5/6Nx mice have enhanced neurovascular transmission and vasoconstriction from an impaired EDH anticontractile component before vascular structural changes. These neurovascular changes depend on an enhanced sympathetic discharge that impairs the expression of Cx43 in gap junctions at MEJs, thereby interrupting EDH responses that normally moderate vascular tone. Dysregulation of neurovascular transmission may contribute to the development of hypertension in CKD.
Paper I: Design and construction of a Knudsen-cell reactor for the study of heterogeneous reactions over the temperature range 130–750 K: Performances and limitations (1997)

A new low-pressure flow reactor operated as a Knudsen cell and intended for chemical kinetic studies is described. The reactor is specifically designed to study the kinetics of heterogeneous reactions. Gas-phase species are detected either by mass-spectrometric sampling or by in situ optical techniques, e.g., laser-induced fluorescence, resonantly enhanced multiphoton ionization. A feature of the reactor is its modular design, allowing full interchangeability of several sample holders at minimal effort, allowing the measurement of uptake coefficients ranging from 10−7 to 1.0. Sample supports operating at low and high temperatures have been developed which cover the stated temperature range. Several experimental examples of the utility of the reactor are detailed. The reliability and error bars of the kinetic results due to the errors and uncertainties associated with the experimental procedures are discussed, in particular for fast heterogeneous processes. It is found that even in the molecular flow regime, for fast reaction, the effects of diffusion limitations within the cell must be taken into account. This fact has been shown here from an experimental point of view. In a companion article the phenomena are studied using Monte Carlo simulation of the gas dynamics under molecular flow conditions.
Estimating client QoE from measured network QoS (2019)

This research is done in the context of the SliceNet project [4] that aims to extend 5G infrastructure with cognitive management of cross-domain, cross-layer network slices [1], with emphasis on Quality of Experience (QoE) for vertical industries. The provisioning of network slices with proper QoE guarantees is seen as one of the key enablers of future 5G-enabled networks. The challenge is to assess the QoE experienced by the vertical application and its users without requiring the applications or the users to measure and report QoE related metrics back to the provider. To address this challenge, we propose a method for deriving application-level QoE from network-level Quality of Service (QoS) measurements, easily accessible by the provider. In particular, we describe a PoC where QoE, perceived by application users, is estimated from low level network monitoring data, by applying cognitive methods. Our main goal is enabling the cloud provider to support the desired E2E QoE-based Service Level Agreements (SLAs), e.g. by monitoring QoS metrics within the provider's domain to optimize resource allocation through provider's actuators. Additional benefit can be achieved by applying the same technique to troubleshoot issues in the provider's infrastructure. In this work, we employed classical statistical methods to assess the relationship between the application-level QoE and the network-level QoS.
Selective Serotonin Reuptake Inhibitor and Akathisia (1997)

Tirat Carmel Mental Health Center, Tirat Carmel, Israel 30200 (Poyurovsky). Geha Psychiatric Hospital, Petah Tiqva, Israel (Weizman).
Nintedanib in children and adolescents with fibrosing interstitial lung disease: the InPedILD trial (2022)

<b>Background:</b> Nintedanib is approved for the treatment of pulmonary fibrosis in adults. There are no licensed treatments for fibrosing ILD in children and adolescents. <b>Aim:</b> The InPedILD trial was designed to determine the dosing and safety of nintedanib in children and adolescents with fibrosing ILD. <b>Methods:</b> Patients aged 6–17 years with fibrosing ILD on 2 HRCTs or on lung biopsy and HRCT (with the most recent HRCT in prior ≤12 months), FVC ≥25% predicted and clinically significant ILD were eligible. Patients were randomised 2:1 to receive nintedanib or placebo double-blind on top of standard of care for 24 weeks followed by open-label nintedanib. Dosing was based on weight-dependent allometric scaling. Co-primary endpoints are the area under the plasma concentration-time curve at steady state at weeks 2 and 26 and the proportion of patients with treatment-emergent adverse events during the double-blind period. FVC will be measured at baseline, weeks 2, 6, 12, 24, and at regular visits thereafter. <b>Results:</b> The trial involved 64 sites in 23 countries. An interim analysis of baseline characteristics from the first 36 patients randomised is shown in the Table. Results will be available in Summer 2022. <b>Conclusion:</b> The InPedILD trial will provide insights into the risk:benefit of nintedanib in children and adolescents with fibrosing ILD.
Development of an imaging-guided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results (2013)

This phase I study demonstrates for the first time that pretargeting with bsMAb TF2 and radiolabelled IMP288 in patients with CEA-expressing CRC is feasible and safe. With this pretargeting method, tumours are specifically and rapidly targeted.
Effect of inhomogeneous broadening on a DPAL based superluminal laser for precision sensing (2012)

In several applications such as optical gyroscopes, gravitational wave detection, and vibrometry, the precision sensing of the effective length of the optical cavity is key. In this work we show how an active single mode laser with a negatively dispersive medium can enhance the sensitivity of measuring the alteration of the length of the cavity in the practical case of a warm medium. We also state how a Rubidium based Diode Pump Alkali Laser satisfies the requirements of the proposed model.
<title>Maskless Laser Plating Techniques For Microelectronic Materials</title> (1983)

We describe techniques for laser enhanced plating of gold, nickel and copper. This maskless plating results in speeds up to 10<sup>3</sup> times that of conventional plating. Mechanisms and applications are discussed.
Photoreduction of Self-Assembled Lipidporphyrinato-iron(III) Chloride with Hyaluronic Acid under Semi-Physiological Conditions (2000)

Abstract Photoirradiation into the LMCT band (λmax: 362 nm) of self-assembled amphiphilic tetraphenylporphyrinato-iron(III) (lipidporphyrinato-iron(III)) chloride with hyaluronic acid leads to reduction of the central ferric ion in saline solution (pH 7.4, 25 °C); the obtained lipidporphyrinato-iron(II) can reversibly bind and release dioxygen.