gebhart/patrepeval huggingface dataset:
A Miniature 500 000-r/min Electrically Driven Turbocompressor (2010)

The trend in compressors for fuel cells, heat pumps, aerospace, and automotive heating, ventilation, and air-conditioning systems is toward ultracompact size and high efficiency. This can be achieved by using turbocompressors instead of scroll, lobe, or screw compressors, increasing the rotational speed and employing new electrical drive system technology and materials. This paper presents a miniature electrically driven two-stage turbocompressor system running at a rated speed of 500 000 r/min. The design includes the thermodynamic analysis, the electric motor, the inverter, the control, and the system integration with rotor dynamics and thermal considerations. Experimental measurements such as the compressor map are presented for air under laboratory conditions. The two-stage turbocompressor has been tested up to a speed of 600 000 r/min, where a maximal pressure ratio of 2.3 at a mass flow of 0.5 g/s has been reached. To the authors' knowledge, this is the highest rotational speed achieved with an electrically driven turbocompressor.
XBphos-Rh: a halogen-bond assembled supramolecular catalyst (2018)

The use of halogen bonding as a tool to construct a catalyst backbone is reported. Specifically, pyridyl- and iodotetrafluoroaryl-substituted phosphines were assembled in the presence of a rhodium(i) precursor to form the corresponding halogen-bonded complex <b>XBphos-Rh</b>. The presence of fluorine substituents at the iodo-containing supramolecular motif was not necessary for halogen bonding to occur due to the template effect exerted by the rhodium center during formation of the halogen-bonded complex. The halogen-bonded supramolecular complexes were successfully tested in the catalytic hydroboration of terminal alkynes.
Phenotypic differences among patients with Bardet‐Biedl syndrome linked to three different chromosome loci (1995)

Bardet-Biedl syndrome (BBS) is an autosomal-recessive disorder of mental retardation, obesity, retinal dystrophy, polydactyly, and hypogenitalism. Renal and cardiac abnormalities are also frequent in this disorder. Previous clinical suggestions of heterogeneity of BBS were confirmed recently by the identification of four different chromosome loci linked to the disease. In this study we compared clinical manifestations of the syndrome in patients from 3 unrelated, extended Arab-Bedouin kindreds which were used for the linkage mapping of the BBS loci to chromosomes 3, 15, and 16. The observed differences included the limb distribution of the postaxial polydactyly and the extent and age-association of obesity. It appears that the chromosome 3 locus is associated with polydactyly of all four limbs, while polydactyly of the chromosome 15 type is mostly confined to the hands. On the other hand, the chromosome 15 type is associated with early-onset morbid obesity, while the chromosome 16 type appears to present the "leanest" form of BBS. Future cloning of the various BB genes will contribute to the understanding of the molecular basis of limb development and to the identification of human obesity-related genes.
Energy Efficiency of the Cell-Free Massive MIMO Uplink With Optimal Uniform Quantization (2019)

A cell-free Massive multiple-input multiple-output (MIMO) uplink is considered, where the access points (APs) are connected to a central processing unit (CPU) through limited-capacity wireless microwave links. The quantized version of the weighted signals are available at the CPU, by exploiting the Bussgang decomposition to model the effect of quantization. A closed-form expression for spectral efficiency is derived taking into account the effects of channel estimation error and quantization distortion. The energy efficiency maximization problem is considered with per-user power, backhaul capacity and throughput requirement constraints. To solve this non-convex problem, we decouple the original problem into two sub-problems, namely, receiver filter coefficient design, and power allocation. The receiver filter coefficient design is formulated as a generalized eigenvalue problem whereas a successive convex approximation (SCA) and a heuristic sub-optimal scheme are exploited to convert the power allocation problem into a standard geometric programming (GP) problem. An iterative algorithm is proposed to alternately solve each sub-problem. Complexity analysis and convergence of the proposed schemes are investigated. Numerical results indicate the superiority of the proposed algorithms over the case of equal power allocation.
In Situ Chemotaxis Assay to Examine Microbial Behavior in Aquatic Ecosystems (2020)

Microbial behaviors, such as motility and chemotaxis (the ability of a cell to alter its movement in response to a chemical gradient), are widespread across the bacterial and archaeal domains. Chemotaxis can result in substantial resource acquisition advantages in heterogeneous environments. It also plays a crucial role in symbiotic interactions, disease, and global processes, such as biogeochemical cycling. However, current techniques restrict chemotaxis research to the laboratory and are not easily applicable in the field. Presented here is a step-by-step protocol for the deployment of the in situ chemotaxis assay (ISCA), a device that enables robust interrogation of microbial chemotaxis directly in the natural environment. The ISCA is a microfluidic device consisting of a 20 well array, in which chemicals of interest can be loaded. Once deployed in aqueous environments, chemicals diffuse out of the wells, creating concentration gradients that microbes sense and respond to by swimming into the wells via chemotaxis. The well contents can then be sampled and used to (1) quantify strength of the chemotactic responses to specific compounds through flow cytometry, (2) isolate and culture responsive microorganisms, and (3) characterize the identity and genomic potential of the responding populations through molecular techniques. The ISCA is a flexible platform that can be deployed in any system with an aqueous phase, including marine, freshwater, and soil environments.
Bio-telemetry and bio-instrumentation technologies for healthcare monitoring systems (2016)

This work presents a review of advancements made in the areas of bio-telemetry and bio-instrumentation for healthcare applications, especially for remote health monitoring in developing nations. This paper presents a comprehensive study of suitable wireless, analog and RF IC technologies, their challenges and limitations, recent researches and future directions in these areas. As an outcome of this study, a prototype of a healthcare monitoring unit (HMU) has been also proposed by using commercial ICs in accordance with the recommendations given by the wireless planning commission (WPC) in India. Using the proposed HMU, bio-signal capturing and communication is demonstrated in home and infirmary environments. Supported with the practical implementation results for actual constraints and conditions, this work promises to give the scholars a quick start for their research in the area of remote healthcare monitoring.
A new method for quantifying the motion of epicardial activation wavefronts (2002)

The authors present a method for analyzing the motion of epicardial wavefronts recorded from a densely spaced electrode array during VF. The method is based on isolating individual wavefronts from the surrounding activity. Each wavefront is then analyzed separately by comparing each frame to a reference frame to obtain the relative position, orientation, and size of the wavefront as a function of time. The method was tested using wavefronts generated by a FitzHugh-Nagumo type propagation model. The results agreed well with the known motion parameters of the models with predictable deviations when the wavefronts contacted the edges of the array. The method can be used to quantify activation patterns during VF and to assess the effects of time or interventions on the arrhythmia.
A Model to Study the Impact of Polymorphism Driven Liver-Stage Immune Evasion by Malaria Parasites, to Help Design Effective Cross-Reactive Vaccines (2016)

Malaria parasites engage a multitude of strategies to evade the immune system of the host, including the generation of polymorphic T cell epitope sequences, termed altered peptide ligands (APLs). Herein we use an animal model to study how single amino acid changes in the sequence of the circumsporozoite protein (CSP), a major target antigen of pre-erythrocytic malaria vaccines, can lead to a reduction of cross reactivity by T cells. For the first time in any APL model, we further compare different inflammatory adjuvants (Montanide, Poly I:C), non-inflammatory adjuvants (nanoparticles), and peptide pulsed dendritic cells (DCs) for their potential capacity to induce broadly cross reactive immune responses. Results show that the capacity to induce a cross reactive response is primarily controlled by the T cell epitope sequence and cannot be modified by the use of different adjuvants. Moreover, we identify how specific amino acid changes lead to a one-way cross reactivity: where variant-x induced responses are re-elicited by variant-x and not variant-y, but variant-y induced responses can be re-elicited by variant-y and variant-x. We discuss the consequences of the existence of this one-way cross reactivity phenomenon for parasite immune evasion in the field, as well as the use of variant epitopes as a potential tool for optimized vaccine design.
Monitoring of non-return valve operation with a variable-speed drive (2015)

Variable-speed drives are a key solution to energy efficiently operating fluid handling systems. Besides speed variation, modern drives are capable to monitor the condition of a fluid handling system. Especially pumps and fans are installed to systems, where the fluid flow is allowed only to a single direction. If the nonreturn valve fails for some reason in a pumping station, economic and environmental consequences may be severe due to flooding. This paper introduces how a variable-speed drive is able to monitor the operation of this critical system component, and how the proposed monitoring methods are working in the laboratory test environment with a failed non-return valve. This paper also provides an insight on customising the variable-speed drive through its internal programmable logic controller.
Shifts in Methanogenic Subpopulations Measured with Antibody Probes in a Fixed-Bed Loop Anaerobic Bioreactor Treating Sulfite Evaporator Condensate (1989)

A fixed-bed loop, high-rate anaerobic bioreactor treating sulfite evaporator condensate was sampled when it reached steady state and afterwards following perturbations during a 14-month period. By using immunotechnology, it was observed that shifts in methanogenic subpopulations occurred in association with perturbations, such as restarting and relocating the biomass into a different tank. Methanogens related to Methanobacterium bryantii MoHG and Methanobrevibacter smithii ALI were numerous throughout the observation period, while Methanosarcina mazei S6 and Methanosarcina thermophila TM1 were found in the early and late samples, respectively. Also, Methanobacterium formicicum was more numerous at the top portion of the bioreactor, while Methanobrevibacter arboriphilus AZ and DC were at the bottom. Sample formalinization required for prolonged storage proved suitable for antigen preservation.
Use Endoscope and Instrument and Pathway Relative Motion as Metric for Automated Objective Surgical Skill Assessment in Skull Base and Sinus Surgery (2018)

Background Endoscopic skull base and sinus surgery (ESBSS) is one of the most common surgical procedures, with over 300,000 surgeries performed in the United States yearly, for treatment of neoplasm, cancer, and chronic sinusitis (CRS). Objective assessment of surgical skills helps surgeons with skill improvement and leads to improved patient care; however, it is extremely expensive and requires experts to review surgical video. In many instances, this is prohibitively resource intensive. In this study, we propose an automated objective skill assessments based on instrument and endoscope motion.
Prestack elastic waveform in version using a priori information (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999Prestack elastic waveform in version using a priori informationAuthors: T. TonellotD. MacéV. RichardM. CuerT. TonellotIFP, D. MacéIFP, V. RichardIFP, and M. CuerMontpellier II Universityhttps://doi.org/10.1190/1.1821149 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1821149FiguresReferencesRelatedDetailsCited byPoststack, prestack, and joint inversion of P- and S-wave data for Morrow A sandstone characterizationParitosh Singh, Thomas L. Davis, and Bryan DeVault17 July 2015 | Interpretation, Vol. 3, No. 3Uncertainty Analysis for Seismic Inverse Problems: Two Practical Examples12 October 2010Combining the Pilot Point and Gradual Deformation Methods for Calibrating Permeability Models to Dynamic Data14 June 2007 | Oil & Gas Science and Technology - Revue de l'IFP, Vol. 62, No. 2Acoustic impedance estimation after prestack depth migrationFrançois Schaub, Philippe Thierry, Hélène Beucher, and Didier Renard6 October 2006Determining Consistently the A Priori Information Weight in a Stratigraphie Inversion1 October 2000 SEG Technical Program Expanded Abstracts 1999 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION T. Tonellot, D. Macé, V. Richard, and M. Cuer, (1999), "Prestack elastic waveform in version using a priori information," SEG Technical Program Expanded Abstracts : 800-803. https://doi.org/10.1190/1.1821149 Plain-Language Summary PDF DownloadLoading ...
Lighting gel filters as an alternative for low-cost optical system design in point-of-care applications (2021)

Lighting gel filters have been used for over 100 years to modify the color of traditional light sources. Very few applications of gel filters have been recorded in scientific literature despite their potential in low-cost optical design . We propose that key factors that prevent wider adoption of gel filters in scientific applications are a lack of extensive optical characterization and comparison to commonly used dielectric and color glass filters. Here, we perform optical characterization of lighting gel filters and compare their transmission, auto-fluorescence, and photobleaching performance to dielectric and color glass filters. The results indicate that gel filters are a viable low-cost alternative with unique advantages that make them suitable for scientific applications including low-cost smartphone imaging systems and disposable lab-on-chip fluorescence tests.
Integratable Nanowire Transistors (2008)

We report a structure to control nanowire location and growth direction and demonstrate top-gated, metal-oxide-semiconductor, field-effect transistors (MOSFETs) using this structure. The nanowires wereengineered to grow against an oxide surface of a (001), silicon-on-insulator substrate, enabling straightforward fabrication of MOSFETs exhibiting an Io/Ioff ratio approximately 104 and a subthreshold slope of approximately 155 mV/decade. Though nanowires were engineered to grow in (110) directions, the nanowires still grew by the addition of {111) planes.
Preclinical development of GRN163L, a telomerase inhibitor for cancer therapy (2005)

4326 Telomerase is an enzyme required for maintenance of telomeric DNA “capping” of the ends of eukaryotic chromosomes. Without telomerase, telomeres shorten to a critical length, resulting in chromosomal instability, and cell cycle arrest or death. Human telomerase is repressed in most normal somatic cells, transiently inducible in certain stem or progenitor cells, and constitutively activated in germline and tumor cells. There is a strong correlation between tumorigenesis and telomerase activation, therefore telomerase is considered a promising therapeutic target for the treatment of cancer. GRN163L is a lipid-conjugated thio-phosphoramidate (N3’-P5’) oligonucleotide being developed as the first specific telomerase inhibitor for the treatment of cancer. GRN163L binds tightly to the template region of the RNA component of telomerase, blocking the active site of the enzyme. GRN163L inhibition of telomerase activity results in the slowing of tumor cell growth and progression in vitro as well as inhibiting tumor growth in various in vivo tumor models, including myeloma, hepatocellular, ovarian, and lung cancer. Additionally, combination studies with various cytotoxics, including melphalan, Velcade and taxol in selected tumor models, including melanoma, myeloma and ovarian carcinoma models have demonstrated increased efficacy of GRN163L and chemotherapy co-treatment over either agent alone. Preclinical safety studies indicate that GRN163L generally has a toxicity profile that is similar to that typically observed for the oligonucleotide class of molecules, with a clear relationship between plasma concentration and acute toxicity effects, and are readily managed by dose and infusion time. ADME and pharmacodynamic studies support an intermittent treatment schedule at drug levels that should achieve efficacious concentrations of GRN163L in cancer patients. GRN163L has been manufactured under GLP and GMP conditions, yielding sufficient drug substance to support preclinical toxicity, safety pharmacology, and pharmacokinetic studies, as well as Phase I clinical studies. Selection of the clinical indication(s) and design for Phase I and subsequent clinical studies are in progress with guidance from ongoing preclinical safety, pharmacodynamic and efficacy studies.
Throughput improvements for cellular systems with device-to-device communications (2013)

We consider the resource allocation problem in cellular networks which support Device-to-Device Communications (D2D) under the orthogonal resource sharing setting. We propose and analyze two resource allocation schemes that guarantee perfect access fairness among all users, regardless of whether they are cellular or D2D, while taking advantage of multi-user diversity and local D2D communications to provide marked improvements over existing cellular-only schemes. The first scheme, Cellular Fairness Scheme, provides the simplest D2D extension to existing cellular systems, while the second scheme, D2D Fairness Scheme, harnesses maximal performance from D2D enabled systems under the orthogonal sharing setting.
Normalized Energy Density-Based Forensic Detection of Resampled Images (2012)

We propose a new method to detect resampled imagery. The method is based on examining the normalized energy density present within windows of varying size in the second derivative of the image in the frequency domain, and exploiting this characteristic to derive a 19-D feature vector that is used to train a SVM classifier. Experimental results are reported on 7500 raw images from the BOSS database. Comparison with prior work reveals that the proposed algorithm performs similarly for resampling rates greater than 1, and is superior to prior work for resampling rates less than 1. Experiments are performed for both bilinear and bicubic interpolations, and qualitatively similar results are observed for each. Results are also provided for the detection of resampled imagery with noise corruption and JPEG compression. As expected, some degradation in performance is observed as the noise increases or the JPEG quality factor declines.
Supplementary Figures 1-10 from Loss of 53BP1 Causes PARP Inhibitor Resistance in <i>Brca1</i>-Mutated Mouse Mammary Tumors (2023)

&lt;p&gt;PDF file - 1.2MB, This file contains additional data on tumor responses to olaparib treatment (Fig. S1 and S2), pH2AX stainings on treated and untreated tumors (Fig. S3), analysis of mutations in 53BP1 (Fig. S4 and S7B), characterization of cell lines (Fig. S5), RAD51 and 53BP1 IRIFs in tumors and cell lines (Fig. S6 and S7), 53BP1 in topotecan-resistant tumors (Fig. S8) and tumor responses to AZD2461 treatment (Fig. S9 and S10).&lt;/p&gt;
Raman study of benzene phase transition under high pressure and high temperature (1994)

The phase diagram of benzene has been investigated up to 550 °C and 30 GPa in a diamond anvil cell by Raman scattering. A new triple point at 400 °C and 5 GPa and a new phase of solid benzene, called phase IV, have been located at high temperature. The boundaries separating the different phases have been determined: i) benene II and benzene III; ii) benzene III and benzene III’. The irreversible chemical transformation line of benzene has been determined and can be divided in three parts leading to three different recovered compounds. The resulting P‐T diagram is presented.
A 3-copula function application for design hyetograph analysis. (2005)

A design hyetograph is a synthetic rainfall temporal pattern associated with a return period. Usually it is determined by means of statistical analysis of observed rainfall mean intensity through intensity-duration-frequency (IDF) curves. The other characteristics of a rainfall event, such as the peak, total depth and duration, are found indirectly throughout several phases of hydrological analysis, and trigger suitable work assumptions. The aim of this paper is to apply a multivariate approach in order to analyse jointly observed data of rainfall critical depth, maximum intensity and total depth. In particular, bivariate analysis of intensity-total depth conditioning to critical depth is developed using a 3-copula function to define the trivariate joint distribution function. Following the proposed procedure, once a design return period and related critical depth are selected, it is possible to determine, in a probabilistic way, the intensity and total depth, without advancing a priori hypotheses on the design hyetograph pattern. In a case study, the results obtained with the proposed procedure are compared with those deduced from standard design hyetographs usually applied in practical hydrological applications.
Ionic and Plasma Propulsion for Space Vehicles (1961)

The propulsion of future space vehicles by means of electrical engines appears to be the most practical and effective method for long interplanetary missions. The basic principles of the major class of such electrical engines, viz., those utilizing ionic or plasma acceleration, involve technologies familiar to and largely stemming from the work of electronics engineers and plasma physicists. This paper describes the various methods under investigation today for the acceleration and neutralization of charged particles for use in propulsion. The several topics discussed include the problem of beam neutralization, cesium ion engines, electron-bombardment engines, and magnetic plasma acceleration.
Treatment of metabolic disorders using genomic technologies: Lessons from methylmalonic acidemia (2022)

Hereditary methylmalonic acidemia (MMA) caused by deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) is a relatively common and severe organic acidemia. The recalcitrant nature of the condition to conventional dietary and medical management has led to the use of elective liver and combined liver-kidney transplantation in some patients. However, liver transplantation is intrinsically limited by organ availability, the risks of surgery, procedural and life-long management costs, transplant comorbidities, and a remaining underlying risk of complications related to MMA despite transplantation. Here, we review pre-clinical studies that present alternative approaches to solid organ transplantation as a treatment for MMUT MMA, including adeno-associated viral gene addition therapy, mRNA therapy, and genome editing, with and without nuclease enhancement.