gebhart/patrepeval huggingface dataset:
Analyse et specification de systemes de production pour l'evaluation des performances et la recherche d'ordonnancements (1993)

Les systemes de production posent de nombreux problemes, tant au niveau de leur conception que de leur exploitation. Ces problemes necessitent le recours a l'evaluation des performances du systeme etudie afin d'aider a la decision et d'eviter des investissements inconsideres. Les objectifs de cette these sont d'une part de proposer une methodologie de modelisation pour la classe des systemes de production et d'autre part de chercher des ordonnancements planifies en utilisant un couplage entre des methodes d'ordonnancement et un modele de simulation. La premiere partie de cette these presente les problemes que posent les systemes de production et critique quelques environnements de modelisation existants. La methodologie proposee repose sur une approche hierarchique, une approche orientee-objets et les reseaux de petri pour l'analyse et la specification de l'aspect statique du systeme. La dynamique du systeme est decrite selon une approche transactionnelle. Une technique permettant de generer automatiquement un modele de simulation qnap2 (queueing network analysis package) a partir de la specification est presentee. La deuxieme partie propose un couplage entre des methodes d'ordonnancements et un modele de simulation pour la determination d'ordonnancements planifies de systemes complexes. Ce couplage est mis en uvre avec l'algorithme du recuit simule et avec une heuristique originale nommee sesf qui offre un tres bon rapport temps d'execution/qualite du resultat. La methodologie de modelisation proposee et l'utilisation du couplage pour la recherche d'ordonnancements sont validees sur deux exemples industriels: une chaine de soudure de moteurs d'essuie-glaces du groupe valeo et un atelier de decapage de pieces d'avions
lnterleukin-3 (IL-3) and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Can Induce Differentiation of Chronic B Cell Leukemia Expressing the α Subunit of IL-3 and GM-CSF Receptor (1996)

Interleukin-5 (IL-5), IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) exhibit similar functions on eosinophils, and these common functions are believed to be mediated by the shared beta chain of receptors. IL-5 shows activity on the murine chronic B cell leukemia cell line BCL1-B20, inducing differentiation into IgM-secreting cells, but IL-3 and GM-CSF do not have such activity. To elucidate whether the lineage specificity of IL-5 is due to restricted expression of the IL-5 receptor alpha chain (IL-5R alpha), transfectants of BCL1-B20 were established that express IL-3 receptor alpha (BCL1-3R) or GM-CSF receptor alpha (BCL1-GMR). BCL1-3R and BCL1-GMR acquired responsiveness to IL-3 and GM-CSF, respectively, to an extent similar to IL-5 stimulation, resulting in IgM-secreting cells. Thus, the differentiation of BCL1-B20 into IgM-secreting cells can be equally supported by either IL-3 or GM-CSF, suggesting that intracellular signaling through IL-5R can be replaced by signaling from IL-3R and GM-CSFR. These results support the notion that the lineage specificity of IL-5 is mainly due to the restricted expression of IL-5R alpha. Regulation of IL-5R alpha, IL-3R alpha and GM-CSFR alpha expression in the developmental stage appears to be important for understanding the unique function of these cytokines on a particular cell type.
Reactivity and Structure of Diferrocenylamine and N,N - Diferrocenylcarbamoylchloride (1999)

The reactivity of diferrocenylamine has been investigated aiming at the preparation of novel diferrocenylamino compounds, including nitrenium salts, amino radicals, transition metal amides, carbamato ligands, and others. However, diferrocenylamine is unexpectedly difficult to derivatize; only simple metalation by butyl lithium, alkylation by iodomethane, and chloroformylation by phosgene were possible. X-ray crystal structures are reported for the starting diferrocenylamine, and for the derivatives diferrocenylmethylamine and N,N diferrocenylcarbamoylchloride.
Long Non-coding RNAs Sponging MicroRNAs With Efficacy in Preclinical In Vivo Models of Esophageal Squamous Cell Cancer (2022)

Esophageal cancer is of two subtypes: Esophageal adenocarcinoma and esophageal squamous cell carcinoma (ESCC). Both are associated with a dismal prognosis. Therefore, the identification of new targets and treatment modalities is an issue of paramount importance. In this review, we focus on long non-coding RNAs (lncRNAs) which have been shown to mediate efficacy in preclinical in vivo models of ESCC by sponging microRNAs. Searching the literature, we identified four lncRNAs which were down-regulated and 23 which were up-regulated in comparison to corresponding normal tissues. The down-regulated lncRNAs lead to up-regulation of oncogenic pathways and down-regulation of tumor suppressors. The up-regulated lncRNAs target transcription factors, transmembrane receptors, cell-cycle related proteins, actin-binding proteins, signaling pathways, enzymes including epigenetic modification factors, cellular transport proteins and other categories. We describe reconstitution and inhibition of function of the corresponding lncRNAs and comment on validation and druggability of the identified targets.
L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma (2010)

We identified that L1 is expressed in ICC. L1 plays an important role in the tumor progression of ICC by enhancing cell proliferation, migration, invasion, and survival. L1 may represent a novel therapeutic target for ICC.
Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages (Erratum) (2019)

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
Supplemental Table 2 from Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit (2023)

&lt;p&gt;Patient characteristics of control group&lt;/p&gt;
Coherent-to-incoherent light conversion for optical correlators (2000)

The authors present a novel coherent-to amplified spontaneous emission (ASE) converter based on SOA's cross-gain modulation (XGM) in a counterpropagating configuration. Experimental characterizations of the ASE converter with bit-error rate (BER) measurements at 2.5 and 5 Gb/s are shown. The device capabilities are exploited in a delay lines optical recognizer at 2.5 Gb/s. Recognition is based on a coherent-to-incoherent light conversion followed by a fiber array correlation filter. Experimental evidence here reported shows performance improvement in comparison with a scheme which adopts a standard telecom source.
Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy. (1992)

Localized proton magnetic resonance (MR) spectroscopy was used to define biochemical changes in gray and white matter of the cerebral cortex in 22 patients with diabetes mellitus (DM), including 10 episodes of diabetic ketoacidosis (DKA), compared with MR spectra in 30 healthy subjects. Five distinct metabolic abnormalities were identified: Concentrations of glucose (Glc) (P greater than or equal to .002), ketone body or bodies, myo-inositol (P greater than or equal to .003) (with or without glycine), and choline (Cho) metabolites were increased in both white and gray matter, whereas a significant reduction of N-acetyl metabolites was found in the parietal cortex (P greater than or equal to .003). Diurnal variations in the intracerebral concentration of Glc were demonstrated in a patient with DM whose condition was stable. Elevated concentrations of ketones were detected in three episodes and excess Cho in two episodes of DKA. Evidence obtained with hydrogen-1 MR spectroscopy favors acetone rather than acetoacetate as the ketone present in the brain, which is a major target of biochemical change in DM.
Designed Compounds for Recognition of 10 Base Pairs of DNA with Two AT Binding Sites (2020)

Short AT base pair sequences that are separated by a small number of GCs are common in eukaryotic parasite genomes. Cell-permeable compounds that bind effectively and selectively to such sequences present an attractive therapeutic approach. Compounds with linked, one or two amidine-benzimidazole-phenyl (ABP) motifs were designed, synthesized and evaluated for binding to adjacent AT sites by biosensor-surface plasmon resonance (SPR). A surprising feature of the linked ABP motifs is that a set of six similar compounds has three different minor groove binding modes with the target sequences. Compounds with one ABP bind independently to two separated AT sites. Unexpectedly, compounds with two ABP motifs can bind strongly either as monomers or as cooperative dimers to the full site. The results are supported by mass spectrometry and circular dichroism, and models to explain the different binding modes are presented.
Supplementary Figure Legend from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway (2023)

&lt;p&gt;PDF file - 80K&lt;/p&gt;
Hoogsteen DNA Duplexes of 3‘−3‘- and 5‘−5‘-Linked Oligonucleotides and Triplex Formation with RNA and DNA Pyrimidine Single Strands:  Experimental and Molecular Modeling Studies (1996)

DNA oligonucleotide sequences containing two parallel complementary strands attached through 3'-3' and 5'-5' linkages were synthesized. These oligonucleotides from Hoogsteen base-paired parallel-stranded (PS) hairpin duplexes under appropriate conditions [Kandimalla, E. R., Agrawal, S., Venkataraman, G., & Sasisekharan, V. (1995a) J. Am. Chem. Soc. 117, 6416-6417]. UV melting experiments show that these Hoogsteen hairpin duplexes have a lower thermal stability than that of the Watson-Crick (WC) hairpin duplex (antiparallel) of the same sequence. The circular dichroism (CD) spectrum of the Hoogsteen duplex is different from the canonical B-DNA WC duplex spectrum. The formation of the Hoogsteen duplex is pH-dependent since protonation of cytosine requires lower pH conditions. Studies with oligonucleotides of different loop sizes revel that three- and two-base loops are optimum for the formation of stable Hoogsteen duplexes with 3'-3' and 5'-5' linkages, respectively. The guanine residues in the loop stabilize the duplex as a result of G-G interactions as confirmed by molecular modeling studies. The new PS Hoogsteen duplexes form stable triplexes with complementary (antiparallel to the purine domain) single-stranded RNA and DNA pyrimidine sequences in Py.Pu:Py (pyrimidine third strand-purine WC strand:pyrimidine WC strand) motif. The thermal stability of the resulting triplexes is much higher than that of the conventional triplex (binding of a Hoogsteen pyrimidine third strand to a WC duplex) of the same sequence. The CD spectra of the new triplexes are similar to those of conventional triplexes, suggesting that no conformational change occurs as a result of 3'-3' or 5'-5' linkage. A molecular modeling study was carried out to examine the stereochemical feasibility of the Hoogsteen duplexes and formation of triplexes with single-stranded pyrimidine complementary strands.
ChemInform Abstract: Perspectives on Poly(dopamine) (2013)

Abstract Review: history, chemical relationship to melanins, recent applications, and potential areas for future study; 44 refs.
Approximating subcellular organisation of carbohydrate metabolism during cold acclimation in different natural accessions of Arabidopsis thaliana (2013)

Accessions of Arabidopsis thaliana originating from climatically different habitats show different levels of cold acclimation when exposed to low temperatures. The central carbohydrate metabolism plays a crucial role during this acclimation. Subcellular distribution of carbohydrates over the compartments cytosol, vacuole and plastids, and putative interactions of the compartments, are analyzed in three differentially cold-tolerant accessions of Arabidopsis thaliana, originating from the Iberian Peninsula (C24), Russia (Rschew) and Scandinavia (Tenela), respectively. Subcellular carbohydrate concentrations were determined by applying the nonaqueous fractionation technique. Mathematical modeling and steady-state simulation was used to analyse the metabolic homeostasis during cold exposure. In all accessions, the initial response to cold exposure was a significant increase of plastidial and cytosolic sucrose concentrations. Raffinose accumulated in all cellular compartments of cold-tolerant accessions with a delay of 3 d, indicating that raffinose accumulation is a long-term component of cold acclimation. Minimal rates of metabolite transport permitting steady-state simulations of metabolite concentrations correlated with cold tolerance, indicating an important role of subcellular re-distribution of metabolites during cold acclimation. A highly regulated interplay of enzymatic reactions and intracellular transport processes appears to be a prerequisite for maintaining carbohydrate homeostasis during cold exposure and allowing cold acclimation in Arabidopsis thaliana.
Growth technologies (1993)

The two growth technologies molecular-beam epitaxy (MBE) and vapor-phase epitaxy (VPE) are frequently employed for epitaxial growth, i.e. the crystalline growth of a thin layer on a crystalline substrate. High-quality epitaxial semiconductors with well controlled doping, composition, and thickness can be grown by MBE and VPE. Furthermore, the two growth methods MBE and VPE are capable of growing atomically abrupt doping and compositional profiles. This chapter covers the basic concepts of MBE, VPE, and related growth technologies.
Periodic Lattices of Interacting Self-Assembled Quantum Dots (2001)

Abstract : Overall, in this program, we developed high quality 2D and 3D periodic quantum dot lattices that show strong photoluminescence. In the initial stages of the program, we worked on QD growth on a periodic stressor lattice formed by ordered subsurface dislocations. The dislocation grid was formed by twist bonding.
The 5α-Androstanedione Pathway to Dihydrotestosterone in Castration-Resistant Prostate Cancer (2012)

The survival and progression of prostate cancer are generally dependent on expression of the androgen receptor (AR), as well as the availability of endogenous AR agonists. Originating from the gonads, testosterone is released into circulation and is converted by steroid-5α-reductase in prostate cancer to 5α-dihydrotestosterone (DHT), potently activating AR and driving tumor progression. Advanced prostate cancer is initially treated with gonadal testosterone depletion, which suppresses this cascade of events and typically leads to a treatment response. Eventually, resistance to testosterone deprivation occurs with "castration-resistant" prostate cancer (CRPC) and is driven by the intratumoral synthesis of DHT. The generation of DHT occurs in large part from adrenal 19-carbon precursor steroids, which are dependent on expression of CYP17A1. Although the path from adrenal precursor steroids to DHT was generally thought to require 5α-reduction of testosterone, recent data suggest that it instead involves conversion from Δ-androstenedione by steroid-5α-reductase isoenzyme-1 to 5α-androstanedione, followed by subsequent conversion to DHT. The 5α-androstanedione pathway to DHT therefore bypasses testosterone entirely. Abiraterone acetate effectively inhibits CYP17A1, blocks the synthesis of androgens, and extends the survival of men with CRPC. Further progress in the hormonal treatment of CRPC is dependent on an understanding of the mechanisms that underlie CRPC and resistance to abiraterone acetate.
SYS 0: CENS Systems Research Overview (2006)

Center for Embedded Networked Sensing Systems Research Overview Jeff Burke, Deborah Estrin, Ramesh Govindan, Richard Guy, Mark Hansen, William Kaiser, Eddie Kohler, Todd Millstein, Jens Palsberg, Miodrag Potkonjak, Mani Srivastava, John Villasenor Introduction Deployments to Instruments Addressing challenges of field deployed systems Initial challenges: adaptive self configuration in communication sensing Difficult environment, challenging connectivity issues, heterogeneity FROM… Spatial redundancy Planned long-term deployments Self-configuring autonomy Post-deployment analysis Pre-calibration Trusted communications One user TO ALSO INCLUDE… Actuated placement Rapid short-lived deployments Interactive exploration Live analysis feedback Integrity monitoring Safety and robustness Multiple users Future challenges: Multi-modal, multi-scale observing instruments Architecture of observing systems, supporting rapid deployment and reconfiguration, and supporting multiple and mobile users Selected Research in Posters Distributed Acoustic Arrays • Integrates CENS research in signal processing, localization, time synchronization, and hardware and software platforms • Nodes self-localize (X, Y, Z, Θ) in difficult 3D terrains with foliage, background noise, adverse weather • High accuracy acoustic source localization Node 108 Node 104 Distributed Image Sensing • Vision is a rich sensing modality – Context, shape, motion, presence, color… • Novel Cyclops platform for large-scale networks of low- power low-resolution cameras – Benefits of diverse perspectives and proximity • Energy optimized algorithms, coordinated actuation, dynamic reconfiguration • Deployment of vision network at James Reserve Programming and System Architecture Architecting for Manageability and Robustness Programming High-data Rate Applications Amplifier and Microphone Bio- High-Integrity Design Sensor Networks in the Presence of Failures software faults resource ownership node failures, packet loss calibration, drift, outliers or Interface Platform & System Integrity (debugger, static checkers, run-time fault isolation) Measurement & Data Integrity (detection, remediation, recalibration) 12-bit ADC TelosB mote Control Data USB Interface to PC Network Integrity (network fault isolation) i686 µServer Macroprogramming Distributed Applications Node Crashed Yes Node Crash No Node Rebooted Yes No No Node Reboot Have Neighbors Yes Have Route • Tests on all passively and actively collected statistics (Ovals) • Root causes assigned based on test results (Rectangles) Yes Rx Pkts No Neighbors No No Route No Bad Node Inbound Path No Bad Node Outbound Path Yes Tx Pkts Yes Bad Sink Inbound Path UCLA – UCR – Caltech – USC – CSU – JPL – UC Merced
Light Directed Electrophoretic Deposition: A New Technique for Patterning Materials in 3D (2013)

Abstract not Available.
Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation (1998)

Neurturin (NTN) is a recently characterized member of the glial cell line-derived neurotrophic factor (GDNF)-family which, like GDNF, can promote the survival of certain populations of neuronal cells in peripheral and central nervous systems. To elucidate the roles of NTN and a novel glycosyl-phosphatidylinositol (GPI)-linked receptor protein GFRalpha-3, a member of GDNF-family receptor alpha, in the regulation of peripheral trigeminal innervation and tooth formation, their expression patterns during mouse embryonic (E) and early postnatal (P) development (E10-P5) of the first branchial arch were analyzed by in situ hybridization. NTN mRNAs were observed in oral and cutaneous epithelia of the mandibular process at all studied stages and expression became gradually restricted to the suprabasal epithelial cells. In addition, transcripts were also detected in the epithelium of whisker follicles. In the developing first molar tooth germ, NTN showed a developmentally regulated, spatiotemporally changing expression pattern, which partially correlated with the development of innervation. During the initiation of tooth formation NTN mRNAs were expressed in dental epithelium and during later embryonic development transcripts appeared in the dental papilla mesenchyme. In addition, some transcripts were seen in the dental follicle. During postnatal development, NTN expression was restricted to the dental follicle of the incisor tooth germs. GFRalpha-3 mRNAs were not detected in teeth, but an intense expression was seen in non-neuronal cells surrounding trigeminal nerve fibers and in the trigeminal ganglia during E11-E15. Ganglion explant cultures showed that trigeminal neurons start to respond to exogenous NTN at E12, which correlates to the earlier reported appearance of the Ret-tyrosine kinase receptor in the trigeminal ganglion. Local application of NTN with beads on isolated dental mesenchyme did not stimulate cell proliferation or prevent apoptotic cell death. In addition, exogenous NTN had no effects on tooth morphogenesis in in vitro cultures. Taken together, because trigeminal neurons respond to NTN after first axons have reached their primary epithelial target fields, NTN is apparently not involved in the guidance of pioneer trigeminal nerves to their peripheral targets. However, our results show that NTN is a potent neuritogenic factor and, therefore, may act as a target-field-derived neurotrophic factor for trigeminal nerves during innervation of the cutaneous and oral epithelia as well as dental follicle surrounding the developing tooth. In addition, although NTN appears not to be directly involved in the regulation of tooth morphogenesis, it may have non-neuronal, organogenetic functions during tooth formation.
IOC consensus paper on the use of platelet-rich plasma in sports medicine (2010)

Acute and chronic musculoskeletal injuries in sports are common and problematic for both athletes and clinicians. A significant proportion of these injuries remain difficult to treat, and many athletes suffer from decreased performance and longstanding pain and discomfort. In 2008, the International Olympic Committee (IOC) published a consensus document on the importance of molecular mechanisms in connective tissue and skeletal muscle injury and healing. This document predicted an increase in the use of autologous growth factors, as it has indeed happened following that publication.
Electrocatalytic hydrogenation of unsaturated organic compounds with molecular complexes: Mechanistic views (2023)

Electrocatalytic hydrogenation of π-bonds in unsaturated organic compounds is a promising strategy for electrifying chemical synthesis using renewable energies. This approach not only offers an alternative to the use of molecular hydrogen but also has the potential to unlock original reaction pathways with higher efficiencies or featuring distinct selectivities or functional group tolerances. In this emerging field, such reactivity engineering can be ideally explored with molecular complexes based on a fundamental understanding of the underlying mechanisms. Recent developments on the hydrogenation of organic π-bonds via molecular electrocatalysis and related key mechanistic features are presented in this viewpoint. Perspectives are drawn to highlight the less explored areas of the catalytic space and point the way to improved catalytic systems.