gebhart/patrepeval huggingface dataset:
<title>Preliminary clinical data on a new photodynamic therapy photosensitizer: 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) for treatment of obstructive esophageal cancer</title> (2000)

Limited therapeutic options exist when chest wafl recurrence from breast cancer progresses despite standard salvage treatment. As photodynamic therapy offers excellent response for cutaneous lesions this may be a possible indication for PDT. A total of 1 02 treatment fields were illuminated on 9 women with biopsy proven chest wall recurrence of breast cancer which was progressing despite salvage surgery, radiation, and chemo-hormonal therapy. PDT consisted of outpatient IV infusion ofPhotofrmn at 0.8 mg/kg followed 48 hours later by illumination at 140-170 J/cm2 via a KTP Yag laser coupled to a dye unit. No patient was lost to follow up. At 6 months post PDT; complete response, defined as total lesion elimination was 89%, partial response 8%, and no response 3%. No photosensitivity was seen and no patient developed scarring, fibrosis, or healing difficulties. Low dose Photofrmn induced PDT is very active against chest wall lesions. Despite fragile and heavily pre-treated tissues, excellent clinical and cosmetic outcome was obtained. PDT is an underutilized modality for this indication.
Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells (1992)

The kit ligand (KL), also termed stem cell factor (SCF), is a recently discovered hematopoietic growth factor that augments response of early progenitor cells to other growth factors and supports proliferation of continuous mast cell lines. Histological studies suggest that the receptor for SCF/KL, the c-kit proto-oncogene product, is present in bone marrow megakaryocytes. We studied the effects of SCF/KL on immortalized human megakaryocytic cell lines (CMK, CMK6, and CMK11–5) and on isolated human marrow megakaryocytes. Human SCF/KL alone or in combination with the hematopoietic growth factors, interleukin-3 (IL- 3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL- 6, stimulated proliferation of these megakaryocytic cell lines. SCF/KL treatment did not alter expression of gpIb, gpIIb/IIIa, LFA-1, ICAM-1, or GMP-140 in CMK cells. No effect on ploidy was observed. Furthermore, human SCF/KL induced expression of IL-1 alpha, IL-1 beta, IL-2, and IL- 6 in CMK cells. In a fibrin clot system, SCF/KL modestly potentiated megakaryocyte colony formation when added alone to cultures containing CD34+, DR+ bone marrow cells. Addition of SCF/KL with IL-3 or GM-CSF to these cultures resulted in a more marked marrow megakaryocytic cells. SCF/KL may directly affect megakaryocytopoiesis, as well as secondarily modulate hematopoiesis through induction of cytokines in target cells.
Clustering Data-Driven Local Control Schemes in Active Distribution Grids (2020)

Controllable distributed energy resources (DERs) in active distribution grids (ADGs) provide operational flexibility to system operators, thereby, offering the means to address various challenges. Existing local controllers for these resources are communication-free, robust, and cheap, but with suboptimal performance compared to centralized approaches that heavily rely on monitoring and communication. Data-driven local controls can bridge the gap by providing customized local controllers designed from historical data, offline optimization, and machine learning methods. These local controllers emulate the optimal behavior under expected operating conditions, without the use of communication. However, they exhibit high implementation overhead with the need of individual programming of DER controllers, especially when there are many DERs or when new units are installed at a later stage. In this article, we propose a clustering method to decrease the implementation overhead by reducing the individual DER controls into a smaller set while still achieving high performance. We show the performance of the method on a three-phase, unbalanced, low-voltage, distribution network.
Synthesis, structural characterization, and reactivity toward weak, protic electrophiles of di-.mu.-hydroxytetrakis(pentafluorophenyl)dipalladate(2-) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, structural characterization, and reactivity toward weak, protic electrophiles of di-.mu.-hydroxytetrakis(pentafluorophenyl)dipalladate(2-)Gregorio Lopez, Jose Ruiz, Gabriel Garcia, Consuelo Vicente, Jaime Casabo, Elies Molins, and Carlos MiravitllesCite this: Inorg. Chem. 1991, 30, 12, 2605–2610Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ic00012a008https://doi.org/10.1021/ic00012a008research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Detection of 100 aM Fluorophores Using a High-Sensitivity On-Chip CE System and Transient Isotachophoresis (2006)

We present a highly sensitive capillary electrophoresis (CE) assay that combines transient, single-interface on-chip isotachophoresis (ITP) and a laser-induced confocal fluorescence detection setup. We performed experimental parametric studies to show the effects of microscope objective specifications and intensity of excitation laser on optimization of a high-sensitivity on-chip CE detection system. Using the optimized detection system, single-molecule detection of Alexa Fluor 488 was demonstrated, and signal data were validated with autocorrelation analysis. We also demonstrated a separation and detection of 100 aM fluorophores (Alexa Fluor 488 and bodipy) in a fast assay using a high-sensitivity on-chip CE detection system and an ITP/CE protocol with no manual buffer exchange steps. This is, to the knowledge of the authors, the highest electrophoretic separation sensitivity ever reported.
IS-IS TE Attributes per application (2020)

Existing traffic engineering related link attribute advertisements
have been defined and are used in RSVP-TE deployments. In cases where
multiple applications wish to make use of these link attributes the
current advertisements do not support application specific values for
a given attribute nor do they support indication of which applications
are using the advertised value for a given link. This draft
introduces new link attribute advertisements which address both of
these shortcomings. It also discusses backwards compatibility issues
and how to minimize duplicate advertisements in the presence of
routers which do not support the extensions defined in this document.
Capture of syncytin-Mar1, a Fusogenic Endogenous Retroviral Envelope Gene Involved in Placentation in the Rodentia Squirrel-Related Clade (2014)

Syncytin genes are fusogenic envelope protein (env) genes of retroviral origin that have been captured for a function in placentation. Within rodents, two such genes have previously been identified in the mouse-related clade, allowing a demonstration of their essential role via knockout mice. Here, we searched for similar genes in a second major clade of the Rodentia order, the squirrel-related clade, taking advantage of the complete sequencing of the ground squirrel Ictidomys tridecemlineatus genome. In silico search for env genes with full coding capacity identified several candidate genes with one displaying placenta-specific expression, as revealed by quantitative reverse transcription-PCR analysis of a large panel of tissues. This gene belongs to a degenerate endogenous retroviral element, with recognizable hallmarks of an integrated provirus. Cloning of the gene in an expression vector for ex vivo cell-cell fusion and pseudotype assays demonstrated fusogenicity on a large panel of mammalian cells. In situ hybridization on placenta sections showed specific expression in domains where trophoblast cells fuse into a syncytiotrophoblast at the fetomaternal interface, consistent with a role in syncytium formation. Finally, we show that the gene is conserved among the tribe Marmotini, thus dating its capture back to about at least 25 million years ago, with evidence for purifying selection and conservation of fusogenic activity. This gene that we named syncytin-Mar1 is distinct from all seven Syncytin genes identified to date in eutherian mammals and is likely to be a major effector of placentation in its related clade. Importance: Syncytin genes are fusogenic envelope genes of retroviral origin, ancestrally captured for a function in placentation. Within rodents, two such genes had been previously identified in the mouse-related clade. Here, in the squirrel-related rodent clade, we identified the envelope gene of an endogenous retrovirus with all the features of a Syncytin: it is specifically expressed in the placenta of the woodchuck Marmota monax, at the level of cells fusing into a syncytium; it can trigger cell-cell and virus-cell fusion ex vivo; and it has been conserved for >25 million years of evolution, suggesting an essential role in its host physiology. Remarkably, syncytin-Mar1 is unrelated to all other Syncytin genes identified thus far in mammals (primates, muroids, carnivores, and ruminants). These results extend the range of retroviral envelope gene "domestication" in mammals and show that these events occurred independently, on multiple occasions during evolution to improve placental development in a process of convergent evolution.
ChemInform Abstract: Use of Ir4(CO)11 to Measure the Lengths of Organic Molecules with a Scanning Transmission Electron Microscope. (1988)

Abstract Studies show that small Ir 4 (CO) 11 clusters are useful for scanning transmission electron microscopy labeling.
Two Faces Of Adult Blood Vessel Formation: Vasculogenesis And Angiogenesis (2014)

During development our blood vascular system successively goes through a vasculogenic and angiogenic growth phase during which a primitive and mature vascular network, respectively, is laid down to provide all tissues with oxygen and nutrients. Rather than being a network of rigid tubes, the established blood vasculature turns out to be a very dynamic system that also after birth can be reshaped to meet the perfusional needs of our organs or to respond to pathological triggers such as cancer. Initially, it was thought that this reshaping only occurred through angiogenic mechanisms1Associate Professor, Molecular and Vascular Biology Research Unit, Endothelial Cell Biology Unit, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, B-3000 Leuven, Belgium. Email: aernout.luttun@med.kuleuven.be 2Professor, Vesalius Research Center, Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, VIB – Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 4, Herestraat 49, B-3000 Leuven, Belgium. Email: peter.carmeliet@vib-kuleuven.be *Corresponding authorList of abbreviations after the text.
Characterization of an aerobic repressor that coordinately regulates bacteriochlorophyll, carotenoid, and light harvesting-II expression in Rhodobacter capsulatus (1995)

For most species of purple photosynthetic bacteria, the presence of molecular oxygen represses synthesis of carotenoids and bacteriochlorophyll. In this study we characterize a strain of Rhodobacter capsulatus, DB469, which contains a genomic disruption of an open reading frame in the photosynthesis gene cluster termed ORF469. Characterization of the steady-state level of bacteriochlorophyll synthesis demonstrates that disruption of ORF469 results in a 2.5-fold increase in aerobic synthesis of bacteriochlorophyll over that observed with the parent strain. Utilizing reporter plasmids that contain transcriptional fusions of lacZ to various carotenoid and bacteriochlorophyll biosynthesis genes, we also demonstrate that disruption of ORF469 leads to an approximate twofold increase in bacteriochlorophyll and carotenoid gene expression under anaerobic growth conditions. Similar analysis with reporter plasmids that contain translational fusions of lacZ to the puf, puh, and puc operons demonstrates that disruption of ORF469 leads to elevated levels of aerobic transcription of light harvesting-II genes (puc), without affecting light harvesting-I or reaction center gene expression (puf and puh, respectively). Gel mobility analysis demonstrates that DB469 cells lack a DNA-binding protein that interacts with a palindromic sequence in the bchC promoter region. The results of this study indicate that ORF469 codes for a DNA-binding protein that acts as an aerobic repressor of promoters for bacteriochlorophyll, carotenoid, and light harvesting-II gene expression.
Excitation energy transfer and spatial exciton confinement in polyfluorene blends for application in light-emitting diodes (2002)

We present picosecond time-resolved studies of thin films of two polyfluorene blends, combining a relatively high energy-gap poly(9,9-dioctylfluorene), PFO, and a polyfluorene derivative with a smaller gap. These studies show both efficient energy transfer from the donor to the acceptor, as well as spatial confinement of the excitons in the acceptor polymers. The optoelectronic characteristics of light-emitting diodes fabricated with such blends reflect the contribution of these two processes. The electroluminescence is almost exclusively from the acceptor polyfluorenes and we observe a significant improvement of the electroluminescence efficiency of the light-emitting diodes fabricated with such blends in comparison to those based on neat films of the polyfluorenes.
ChemInform Abstract: Aromatic Lithiation Directed by the Carboxylic Acid Groups. Synthesis of 9‐Substituted Dibenzodioxin‐1‐carboxylic Acids and 6‐Substituted Phenoxathiin‐4‐carboxylic Acids. (1990)

Abstract Regioselective lithiation of the acids (I) and subsequent quenching with carbon dioxide followed by esterification yield the corresponding diesters (IV).
Endophytes Increased Fruit Quality with Higher Soluble Sugar Production in Honeycrisp Apple (Malus pumila) (2020)

Endophytes are fungi, bacteria, or yeast symbionts that live in the intercellular spaces or vascular tissues of host plants. Investigations indicate that endophytes isolated from the Salicaceae family (<i>Populus</i> and <i>Salix</i>) hosts provide several benefits that promote plant growth, including but not limited to di-nitrogen fixation, plant hormone production, nutrient acquisition, stress tolerance, and defense against phytopathogens. In exchange, the microorganisms receive domicile and photosynthates. Considering the known characteristics of nitrogen fixation and plant hormone production, we hypothesized that apple trees grown under nitrogen-limited conditions would show improved biometrics with endophyte inoculation. Our research objectives were to investigate the endophyte effects on plant physiology and fruiting. We examined these effects through ecophysiology metrics involving rates of photosynthesis, stomatal conductance and density, transpiration, biomass accretion, chlorophyll content and fluorescence, and fruit soluble sugar content and biomass. Our results showed evidence of the endophytes' colonization in apple trees, decreased stomatal density, delayed leaf senescence, and increased lateral root biomass with endophytes. A highlight of the findings was a significant increase in both fruit soluble sugar content and biomass. Future research into the mechanistic underpinnings of this phenomenon stands to offer novel insights on how microbiota may alter carbohydrate metabolism under nitrogen-deficient conditions.
A Novel Anti-inflammatory D-peptide Halts Disease Phenotype Progression in an Als Mouse Model (2020)

Abstract Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by selective neuronal death in brain stem and spinal cord. The cause is unknown, but an increasing evidence has firmly certified that neuroinflammation plays a key role in ALS pathogenesis. Neuroinflammation is a pathological hallmark of several neurodegenerative disorders and has been implicated as driver of disease progression. Here, we describe two treatment studies demonstrating the therapeutic potential of a tandem version of the well-known all-d-peptide RD2 (RD2RD2) in a transgenic mouse model of Alzheimer’s disease (APP/PS1) and in a transgenic mouse model of ALS (SOD1*G93A). Methods: APP/PS1 and SOD1*G93A mice were treated intraperitoneally for four weeks mice with RD2RD2 vs placebo. APP/PS1 brain and plasma samples were histologically and biochemically analysed for inflammatory markers, gliosis and amyloid pathology. SOD1*G93A mice were tested longitudinally during treatment in various behavioural and motor coordination tests. Brain and spinal cord samples were investigated immunohistochemically for gliosis and neurodegeneration. Results: Treatment in APP/PS1 mice revealed significant reduction in glial cell activation in the brain and significantly lower levels of inflammatory cytokines in plasma. RD2RD2 treatment in SOD1*G93A mice resulted not only in a reduction of activated astrocytes and microglia in both brain stem and lumbar spinal cord but also in a rescue of neurons in the motor cortex. Moreover, behavioural tests revealed that the disease phenotype of SOD1*G93A mice is halted during treatment. Conclusion: Based on the presented results, we conclude that RD2RD2 is a potential therapeutic candidate against ALS.
Don't get Lost in Negation: An Effective Negation Handled Dialogue Acts Prediction Algorithm for Twitter Customer Service Conversations (2018)

In the last several years, Twitter is being adopted by the companies as an alternative platform to interact with the customers to address their concerns. With the abundance of such unconventional conversation resources, push for developing effective virtual agents is more than ever. To address this challenge, a better understanding of such customer service conversations is required. Lately, there have been several works proposing a novel taxonomy for fine-grained dialogue acts as well as develop algorithms for automatic detection of these acts. The outcomes of these works are providing stepping stones for the ultimate goal of building efficient and effective virtual agents. But none of these works consider handling the notion of negation into the proposed algorithms. In this work, we developed an SVM-based dialogue acts prediction algorithm for Twitter customer service conversations where negation handling is an integral part of the end-to-end solution. For negation handling, we propose several efficient heuristics as well as adopt recent state-of- art third party machine learning based solutions. Empirically we show model's performance gain while handling negation compared to when we don't. Our experiments show that for the informal text such as tweets, the heuristic-based approach is more effective.
Non-circular multi-core fibers for super-dense SDM (2018)

Non-circular multi-core fibers (NC-MCFs) to accommodate more than 100 cores per fiber are proposed for super-dense space-division multiplexing. The proposed MCFs have the potential for easier splicing/connection and their applicability to highly-dense ribbon MCFs for ultra-high capacity optical transport systems.
Correlated Insulating States in Twisted Double Bilayer Graphene (2019)

We present a combined experimental and theoretical study of twisted double bilayer graphene with twist angles between 1° and 1.35°. Consistent with moiré band structure calculations, we observe insulators at integer moiré band fillings one and three, but not two. An applied transverse electric field separates the first moiré conduction band from neighboring bands, and favors the appearance of correlated insulators at 1/4, 1/2, and 3/4 band filling. Insulating states at 1/4 and 3/4 band filling emerge only in a parallel magnetic field (B_{||}), whereas the resistivity at half band filling is weakly dependent on B_{||}. Our findings suggest that correlated insulators are favored when a moiré flat band is spectrally isolated, and are consistent with a mean-field picture in which insulating states are established by breaking both spin and valley symmetries at 1/4 and 3/4 band filling and valley polarization alone at 1/2 band filling.
Positive pressure infusion of therapeutic agents into brain tissues: Mathematical and experimental simulations (2005)

Positive pressure infusion is a clinical means of achieving convection-enhanced delivery of therapeutic agents within the tissues of the central nervous system for the treatment of glioblastoma multiforme and other diseases of the brain. We have developed a mathematical model of the technique and an in vitro gelatin surrogate for it, which provide biophysical insights into the performance characteristics of candidate infusion systems and drug delivery protocols. We present a brief overview of the clinical problems that are being addressed, succinctly describe the mathematical and in vitro models used in our laboratories, and highlight some representative results from our studies. A number of references to related work are provided for those seeking further details.
Affinity purification of mouse monoclonal IgE using a protein A mimetic ligand (TG19318) immobilized on solid supports (1998)

A synthetic ligand (TG19318), deduced from the screening of a combinatorial peptide library, has been previously characterized by our group for its applicability in affinity chromatography for polyclonal and monoclonal IgG purification from crude sources. In this study we have extended the characterization of its recognition properties for other immunoglobulin classes, evaluating its ability to purify mouse monoclonal IgE from ascitic fluid. TG19318 affinity columns proved useful for a very convenient one-step purification of IgE directly from crude ascites, by loading the samples on the columns equilibrated with 50 mM sodium phosphate at pH 7 and eluting and adsorbed IgE by a buffer change to 0.1 M acetic acid. Antibody purity after affinity purification was very high and no albumin traces were detected, as determined by SDS-PAGE analysis. Antibody activity was fully recovered after purification, as determined by immunoassays on antigen-coated plates, and up to 5 mg of IgEs could be purified on a 1 ml column in a single run.
Characteristics of an ultrasonic motor capable of generating a multi-degrees of freedom motion (2002)

The authors developed a bar-shaped ultrasonic motor capable of generating a multi-DOF motion. The multi-DOF ultrasonic motor consists of a bar-shaped stator and a spherical rotor. The spherical rotor is rotated around three perpendicular axes by the three natural vibrations excited on the stator. In the present study, the driving and control characteristics around one driving axis, which is perpendicular to the stator's geometric axis, are measured in detail, namely the relationship between the frequency of the input signal and the rotational speed, the relationship between the torque and the rotational speed and the step response of the ultrasonic motor, are measured. The maximum rotational speed and the maximum torque are 183 rpm and 5 mNm, respectively. The rotational speed was controlled successfully.