gebhart/patrepeval huggingface dataset:
Crystal and molecular structure of bis(.mu.-bromo)bis(N,N,N',N'-tetraethylethylenediamine)dicopper(I) and the kinetics of its oxidation by dioxygen in nitrobenzene (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of bis(.mu.-bromo)bis(N,N,N',N'-tetraethylethylenediamine)dicopper(I) and the kinetics of its oxidation by dioxygen in nitrobenzeneMelvyn Rowen Churchill, Geoffrey Davies, Mohamed A. El-Sayed, Jay A. Fournier, John P. Hutchinson, and Jon A. ZubietaCite this: Inorg. Chem. 1984, 23, 6, 783–787Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/ic00174a029https://doi.org/10.1021/ic00174a029research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Compound active center of ribonuclease III: molecular basis for double-stranded RNA cleavage (2002)

Since the 7/2-helical model was proposed by our group in 1977 based on the structure of (Pro-Pro-Gly)10, the single crystal structures of model peptides have contributed to obtain important information on the triple-helical structure of collagen. In this study, we report the high resolution crystal structure of collagen model peptide, (Pro-Hyp-Gly)11 using synchrotron diffraction data (SPring-8) at 100K. The structure has been refined to an R-factor of 0.15 and an Rfree-factor of 0.19 using 1960 and 217 reflections respectively, extending up to 1.5 resolution on the layer lines based on the repeating period of 20 . Different from (Pro-Hyp-Gly)10 case, only a few satellite spots were observed above and below the strong reflections on the 20 layer lines. The obtained molecular conformation and hydrogen bonding schemes of peptide chain are essentially the same as those found in the previous analyses of (Pro-Pro-Gly)n (n=9,10) and (Pro-Hyp-Gly)10, which suggests that the peptide molecule in this crystal takes the 7/2-helical conformation. Compared with that of (Pro-Hyp-Gly)10 case where intensity data were collected at room temperature, a fairly large number of water molecules bound to the triple-helical structure were found in this analysis. Most of the newly found water molecules maybe attributed to the data collection temperature together with the analysis at high resolution. All the proline rings of Hyp were found to be up-puckering, while those of Pro showed both up-and down-puckering.
Correction to “Convex Relaxations of Chance Constrained AC Optimal Power Flow” [May 18 2829-2841] (2020)

Presents corrections to above named paper.
Genetic Analysis of a Morphological Shape Difference in the Male Genitalia of Drosophila simulans and D. mauritiana (1996)

Two closely related species of Drosophila, D. simulans and D. mauritiana, differ markedly in morphology of the posterior lobe of the male genital arch. Both size and shape aspects of lobe variation can be quantified by a morphometric descriptor based on elliptical Fourier and principal components analyses. The genetic architecture of this quantitative trait (PC1) was investigated by hybridizing inbred lines to produce two backcross populations approximately 200 individuals each, which were analyzed jointly by a composite interval mapping procedure with the aid of 18 marker loci. The parental lines show a large difference in PC1 (30.4 environmental standard deviations), and the markers account for > 80% of the phenotypic variation in backcross populations. Eight of 15 intervals analyzed show convincing evidence of quantitative trait loci (QTL), and the range of estimated QTL effects is 5.7-15.9% of the parental difference (1.7-4.8 environmental standard deviations). These estimates may represent the joint effects of multiple QTL within a single interval (which averaged 23 cM in length). Although there is some evidence of partial dominance of mauritiana alleles and for epistasis, the pattern of inheritance is largely additive.
The synthesis and structure of pea storage proteins (1984)

The seeds of pea, Pisum sativum L., like those of other legumes, accumulate proteins in their cotyledons during development. These proteins are mainly globulins, soluble in aqueous salt solutions at neutral pH; in keeping with their physiological storage role they are multimeric proteins readily rendered insoluble for deposition, and have high proportions of amide amino acids. They are degraded on germination of the seed to provide nutrients for the growing plant. The two major seed proteins in pea are legumin, a hexameric molecule (Mr ⋍ 380,000) where each monomer (Mr ⋍ 60,000) contains an “acidic”; (Mr ⋍ 40,000) and a “basic”; (Mr ⋍ 20,000) subunit linked by a disulphide bond, and vicilin, a trimeric molecule (Mr ⋍ 150,000) where each monomer (Mr ⋍ 50,000) may contain breaks in its polypeptide chain, giving rise to a variety of smaller subunits. Both these proteins are synthesised on polyribosomes bound to the endoplasmic reticulum in cotyledon cells and are transported from there to membrane‐enclosed protein bodies for deposition. Legumin and vicilin are both modified by post‐translational processing, primarily specific proteolysis, after synthesis in vivo. The major seed storage proteins in pea are produced from mRNA species that are only detectable in seed tissues, and that are transcribed from a limited number (3 to 10) of single copy genes. Regulation of the synthesis of these proteins is determined primarily by mRNA levels, which are in turn determined by separable “switch‐on”; events at the level of gene transcription, alterations in overall transcriptional activity during seed development, and the stability of the mRNA species themselves.
Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis (2020)

Antxr1/Tem8 is highly expressed in tumor endothelial cells and is a receptor for anthrax toxin. Mutation of <i>Antxr1</i> causes GAPO syndrome, which is characterized by growth retardation, alopecia, pseudo-anodontia, and optic atrophy. However, the mechanism underlying the growth retardation remains to be clarified. Runx2 is essential for osteoblast differentiation and chondrocyte maturation and regulates chondrocyte proliferation through <i>Ihh</i> induction. In the search of Runx2 target genes in chondrocytes, we found that <i>Antxr1</i> expression is upregulated by Runx2. <i>Antxr1</i> was highly expressed in cartilaginous tissues and was directly regulated by Runx2. In skeletal development, the process of endochondral ossification proceeded similarly in wild-type and <i>Antxr1</i><sup>-/-</sup> mice. However, the limbs of <i>Antxr1</i><sup>-/-</sup> mice were shorter than those of wild-type mice from embryonic day 16.5 due to the reduced chondrocyte proliferation. Chondrocyte-specific <i>Antxr1</i> transgenic mice exhibited shortened limbs, although the process of endochondral ossification proceeded as in wild-type mice. BrdU-uptake and apoptosis were both increased in chondrocytes, and the apoptosis-high regions were mineralized. These findings indicated that Antxr1, of which the expression is regulated by Runx2, plays an important role in chondrocyte proliferation and that overexpression of <i>Antxr1</i> causes chondrocyte apoptosis accompanied by matrix mineralization.
Colloidal Polymers from Dipolar Assembly of Cobalt-Tipped CdSe@CdS Nanorods (2014)

The synthesis of a modular colloidal polymer system based on the dipolar assembly of CdSe@CdS nanorods functionalized with a single cobalt nanoparticle "tip" (CoNP-tip) is reported. These heterostructured nanorods spontaneously self-assembled via magnetic dipolar associations of the cobalt domains. In these assemblies, CdSe@CdS nanorods were carried as densely grafted side chain groups along the dipolar NP chain to form bottlebrush-type colloidal polymers. Nanorod side chains strongly affected the conformation of individual colloidal polymer bottlebrush chains and the morphology of thin films. Dipolar CoNP-tipped nanorods were then used as "colloidal monomers" to form mesoscopic assemblies reminiscent of traditional copolymers possessing segmented and statistical compositions. Investigation of the phase behavior of colloidal polymer blends revealed the formation of mesoscopic phase separated morphologies from segmented colloidal copolymers. These studies demonstrated the ability to control colloidal polymer composition and morphology in a manner observed for classical polymer systems by synthetic control of heterostructured nanorod structure and harnessing interparticle dipolar associations.
Zero-Truncated Poisson Regression for Sparse Multiway Count Data Corrupted by False Zeros (2022)

We propose a novel statistical inference methodology for multiway count data that is corrupted by false zeros that are indistinguishable from true zero counts. Our approach consists of zero-truncating the Poisson distribution to neglect all zero values. This simple truncated approach dispenses with the need to distinguish between true and false zero counts and reduces the amount of data to be processed. Inference is accomplished via tensor completion that imposes low-rank tensor structure on the Poisson parameter space. Our main result shows that an $N$-way rank-$R$ parametric tensor $\boldsymbol{\mathscr{M}}\in(0,\infty)^{I\times \cdots\times I}$ generating Poisson observations can be accurately estimated by zero-truncated Poisson regression from approximately $IR^2\log_2^2(I)$ non-zero counts under the nonnegative canonical polyadic decomposition. Our result also quantifies the error made by zero-truncating the Poisson distribution when the parameter is uniformly bounded from below. Therefore, under a low-rank multiparameter model, we propose an implementable approach guaranteed to achieve accurate regression in under-determined scenarios with substantial corruption by false zeros. Several numerical experiments are presented to explore the theoretical results.
HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design (2014)

The human epidermal growth factor receptor (HER)2 provides an excellent target for selective delivery of cytotoxic drugs to tumor cells by antibody-drug conjugates (ADC) as has been clinically validated by ado-trastuzumab emtansine (Kadcyla(TM)). While selecting a suitable antibody for an ADC approach often takes specificity and efficient antibody-target complex internalization into account, the characteristics of the optimal antibody candidate remain poorly understood. We studied a large panel of human HER2 antibodies to identify the characteristics that make them most suitable for an ADC approach. As a model toxin, amenable to in vitro high-throughput screening, we employed Pseudomonas exotoxin A (ETA') fused to an anti-kappa light chain domain antibody. Cytotoxicity induced by HER2 antibodies, which were thus non-covalently linked to ETA', was assessed for high and low HER2 expressing tumor cell lines and correlated with internalization and downmodulation of HER2 antibody-target complexes. Our results demonstrate that HER2 antibodies that do not inhibit heterodimerization of HER2 with related ErbB receptors internalize more efficiently and show greater ETA'-mediated cytotoxicity than antibodies that do inhibit such heterodimerization. Moreover, stimulation with ErbB ligand significantly enhanced ADC-mediated tumor kill by antibodies that do not inhibit HER2 heterodimerization. This suggests that the formation of HER2/ErbB-heterodimers enhances ADC internalization and subsequent killing of tumor cells. Our study indicates that selecting HER2 ADCs that allow piggybacking of HER2 onto other ErbB receptors provides an attractive strategy for increasing ADC delivery and tumor cell killing capacity to both high and low HER2 expressing tumor cells.
Sensitivity and Specificity of Immunostaining in the Diagnosis of Mantle Zone Lymphoma (1986)

The diagnosis of mantle zone lymphoma is sometimes difficult to make solely on the basis of morphology because the mantle zone pattern may be present in other disorders such as benign mantle zone hyperplasia, follicular center cell (FCC) lymphomas, and Castleman disease. To distinguish mantle zone lymphoma from the other disorders mentioned previously, the authors performed immunoperoxidase studies on B-5-fixed, paraffin-embedded sections or cryostat sections of lymph nodes from nine patients with a diagnosis of mantle zone lymphoma. The results then were compared with the immunostaining pattern seen in FCC lymphomas and various benign lymphoid hyperplasias. A monoclonal proliferation of mantle zone cells, as shown by staining for immunoglobulin light chains, was noted in the mantle zones and interfollicular areas in all six cases from which cryostat sections were available. The cells in the residual follicular centers uniformly had a polyclonal light chain marking pattern. Two novel monoclonal antibodies (LN-1 and LN-2) that identify FCCs and B-cells in B-5-fixed, paraffin-embedded tissues also were used in this study. Of the six cases in which the monoclonal antibodies could be used, the cells in the residual follicles were uniformly LN-1 positive, LN-2 positive, while the mantle zone and interfollicular cells were almost completely LN-1 negative, LN-2 positive. The data suggest that mantle zone lymphomas are a distinctive neoplasm of monoclonal B-cells of non-FCC origin. The authors conclude that immunostaining is a sensitive technic for identifying a malignant neoplasm of B-cells in the mantle zone and interfollicular areas. In addition, the method is relatively specific and useful for distinguishing mantle zone lymphoma from similar-appearing disorders such as benign mantle zone hyperplasias and certain FCC lymphomas.
Cellular Uptake of Polymer Nanoparticles Imaged by Electron Microscopy Based on High-Pressure Freezing (2007)

Extended abstract of a paper presented at MC 2007, 33rd DGE Conference in Saarbrücken, Germany, September 2 – September 7, 2007
Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins (2012)

Random insertional mutagenesis performed on a Lactococcus lactis reporter strain led us to identify L. lactis ybdD as a protein-overproducing mutant. In different expression contexts, the ybdD mutant shows increased levels of exported proteins and therefore constitutes a new and attractive heterologous protein production host. This study also highlights the importance of unknown regulatory processes that play a role during protein secretion.
Sensor network serial communication system with high tolerance to timing and topology variations (2015)

This article presents the first wireline sensor network to use the delay window clock and data recovery (CDR) algorithm, which allows network nodes to communicate without high precision embedded clocks or a global clock. Changes in the topology of the network caused the transmission rates of the sensor nodes to vary. The mean data period measured on the network ranged from 738.79 ns to 811.25 ns and the standard deviation of periodic jitter (PJ) ranged from 0.7640 ns to 24.01 ns, depending on topology. Data sent from the sensor nodes was successfully recovered for all test cases without modifying the CDR, despite high PJ.
Supplementary Figure S3 from Identification of Somatically Acquired <i>BRCA1/2</i> Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer (2023)

&lt;p&gt;MAF of mutations detected&lt;/p&gt;
Life Thermoscope: Integrated Microelectronics for Visualizing Hidden Life Rhythm (2008)

This paper clarifies the shape of new life-integration electronics to come and proposes novel low-power technologies inherent in this direction. This new electronics pursues amplification of human capability and enables human growth, just like a mirror. An ultra-small 30cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> module has been developed for use as a wearable Sensornet/Internet terminal. A basic low-power technique "rhythm detection" for the life-integration era is proposed. This allows the detection of human life rhythm, reflects one's inner state, allows us to directly face one's hidden shapes. Based on innovation of human-activity sensing through temperature rhythm detection, a microscopic image covering a four-month period has been successfully constructed.
Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation (2013)

The use of tissue adhesives for internal clinical applications is limited due to a lack of materials that balance strong adhesion with biocompatibility. The use of substrate topography is explored to reduce the volume of a highly reactive and toxic glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels to patches employing large amounts of adhesive, and is superior to the level of adhesion achieved when a thin coating is applied to a non-textured patch. In vivo studies demonstrate reduced tissue inflammation and necrosis for patterned patches with a thinly coated layer of reactive glue, thus overcoming a significant challenge with existing tissue adhesives such as cyanoacrylate. Closure of surgical stomach and colon defects in a rat model is achieved without abdominal adhesions. Harnessing the synergy between surface topography and reactive chemistry enables controlled tissue adhesion with an improved biocompatibility profile without requiring changes in the chemical composition of reactive tissue glues.
ActivPass (2015)

This paper explores the feasibility of automatically extracting passwords from a user's daily activity logs, such as her Facebook activity, phone activity etc. As an example, a smartphone might ask the user: "Today morning from whom did you receive an SMS?" In this paper, we observe that infrequent activities (i.e., outliers) can be memorable and unpredictable. Building on this observation, we have developed an end to end system ActivPass and experimented with 70 users. With activity logs from Facebook, browsing history, call logs, and SMSs, the system achieves 95% success (authenticates legitimate users) and is compromised in 5.5% cases (authenticates impostors). While this level of security is obviously inadequate for serious authentication systems, certain practices such as password sharing can immediately be thwarted from the dynamic nature of passwords. With security improvements in the future, activity-based authentication could fill in for the inadequacies in today's password-based systems.
Polarization-Dependent Surface-Enhanced Raman Scattering Activity of Anisotropic Plasmonic Nanorattles (2016)

Plasmonic nanorattles composed of solid plasmonic core and porous and hollow plasmonic shell are a novel class of nanostructures that are highly attractive for surface-enhanced Raman scattering (SERS)-based chemical and biological sensing and bioimaging. In this report, we demonstrate the polarization-dependent SERS activity of cuboidal plasmonic nanorattles composed of a solid gold nanorod core and porous and hollow cuboidal shell. Plasmonic coupling between the gold nanorod core and porous and hollow cuboidal shell of the nanorattles results in a large electromagnetic (EM) enhancement at the interior of the nanorattles. Owing to the presence of internal electromagnetic hotspots, the polarization dependence of the plasmonic nanorattles was found to be markedly different compared to that of solid AuNR@Ag nanocuboids. Similar to most conventional anisotropic solid nanostructures, the AuNR@Ag nanocuboids exhibited a polarization-dependent SERS activity that is dominated by the sharp corners and edges. Conversely, the internal electromagnetic hotspot formed between the AuNR and porous shell of cuboidal nanorattle dominates the SERS activity of the anisotropic nanorattles. The results further our understanding of the SERS activity of this promising class of hollow nanostructures with internal electromagnetic hotspots and provide guidelines for the design of highly efficient SERS substrates based on these nanostructures.
A1: Mathematical Appendix (2005)

This appendix contains sections titled: Linear Systems Fourier Series and Fourier Integral Compilation of Basic Properties of the Fourier Transform Special Functions and their Fourier Transforms Convolution and Correlation Convolution Correlation Power Spectral Density and RMS Value Discrete Signals The Sampling Theorem Leakage Indexing of the Numerical Discrete Fast Fourier Transform z-Transform Definition Numerical Evaluation of the z-transform Sinc Interpolation Hankel Transform Definition Numerical Computation Practical Calculation of Diffraction Integrals The Oscillation Problem Spatial and Spectral Resolution Periodic Boundary Conditions x-z Sampling of the Ewald Sphere Equivalent Diffraction Setups Optimal Conditioning of the Fresnel Diffraction Numerical Algorithms Fresnel Integrals Orthogonal Polynomials on Rectangular Domains Chebyshev Polynomials One-dimensional Legendre Polynomials Two-dimensional Chebyshev Polynomials Legendre Polynomials in Two Dimensions Literature
No. 45 The Effect of Paraspinal Muscles on the Improvement of Patients With Degenerative Spondylolisthesis After Surgery (2014)

care level is efficacious because more than 97% of patients recovered before one month.
Design considerations for PM synchronous motors for flux weakening applications (1997)

The initial sizing stage of a design procedure for PM synchronous motors is presented in the paper. Analytical equations are developed and employed to establish a preliminary motor design. The formulae are used to illustrate the influence of the rotor configuration, electromagnetic loading and air-gap thicknesses on the motor performance. Suggestions regarding the improvement of efficiency, power factor, overload performance and PM protection against permanent demagnetization are also given.