gebhart/patrepeval huggingface dataset:
Design and Testing of a Multivariate Optical Element:  The First Demonstration of Multivariate Optical Computing for Predictive Spectroscopy (2001)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionDesign and Testing of a Multivariate Optical Element: The First Demonstration of Multivariate Optical Computing for Predictive SpectroscopyO. Soyemi, D. Eastwood, L. Zhang, H. Li, J. Karunamuni, P. Gemperline, R. A. Synowicki, and M. L. MyrickCite this: Anal. Chem. 2001, 73, 17, 4393Publication Date (Web):July 27, 2001Publication History Published online27 July 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/ac010612hhttps://doi.org/10.1021/ac010612hcorrectionACS PublicationsCopyright © 2001 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views362Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (10 KB) Get e-Alertsclose Get e-Alerts
Ovarian Metastasis from Pancreatic Ductal Adenocarcinoma (2021)

Patients with resected PDAC and ovarian recurrence tend to have a comparable disease course to more common patterns of recurrence. Primaries with nodal disease, poorer grade, vascular invasion, and bilateral ovarian disease were indicative of more aggressive disease biology. The ideal management remains largely unknown, and future collaborative efforts should optimize therapeutic strategies.
Development of an ultrasonic clutch for multi-fingered exoskeleton haptic device using passive force feedback for dexterous teleoperation (2004)

A novel multi-fingered exoskeleton haptic device using passive force feedback has been proposed by the authors. The haptic device solves the conventional problems of previously developed master-slave systems with force feedback, such as oscillations, complex structures and complicated control algorithm. However, some problems still remain in the conventional passive elements. In the present paper, an ultrasonic clutch for multi-fingered exoskeleton haptic device with passive force feedback function is developed. The ultrasonic clutch can solve problems of conventional passive elements, such as time delay, instability, and large size, by using unique characteristics of ultrasonic motor, as fast response, silent motion, and non-magnetic feature. It can also be designed to be smaller than conventional elements due to its simple structure. The clutch locks or releases the rotor by use of ultrasonic levitation phenomenon. First, we have designed the structure of the ultrasonic clutch using an equation of ultrasonic levitation phenomenon, results from structural analysis and finite element (FE) analysis of piezoelectric material of the vibrator. Then we have manufactured the ultrasonic clutch and have conducted a driving experiment. Finally, we have demonstrated that the maximum levitation force is around 20 N and the static friction torque of the ultrasonic clutch is up to 0.14 Nm.
Temporal scalability and layered transmission (2008)

The deployment of mobile multimedia broadcast services like mobile TV over cellular networks has just started. The coverage in terms of delivered quality per receiver is an important measure to evaluate the experienced quality. In order to provide a reasonable quality for all receivers in a network cell, we analyze graceful degradation techniques in Rel. 6 of 3rd Generation Partnership Project's (3QPP) Multimedia Broadcast and Multicast Services (MBMS). We show the benefits of using H.264/AVC temporal scalability in an existing system for graceful degradation in order to add coverage for users in poor reception conditions, although at a reduced level of quality. For that we define assessment techniques for measuring the quality coverage describing the amount of users reached with a certain media play-out quality. We connect this quality coverage to a measure for used network cell capacity giving the used network resources for 3QPP Rel. 6 network cells. We evaluate graceful degradation under simulated 3QPP Rel. 6 network conditions showing the benefits of graceful degradation for 3QPP MBMS mobile television services.
A Triple-Band WCDMA Direct Conversion Receiver IC with Reduced Number of Off-Chip Components and Digital Baseband Control Signals (2008)

This paper presents a triple-band WCDMA direct conversion receiver (DCR) IC that needs a small number of off-chip components and control signals from digital baseband (DBB) IC. The DCR IC consists of 3 quadrature demodulators (QDEMs) with on-chip impedance matching circuit and an analog baseband block (ABB) that contains a low-pass filter (LPF) with fc automatic tuning circuit using no off-chip components and a linear-in-dB variable-gain amplifier (VGA) with on-chip analog high-pass filter (HPF). In order to make use of DBB control-free DC offset canceler, the DCR is designed to avoid large gain change under large interference that causes long transient response. In order to realize that characteristic without increasing quiescent current, the QDEM is used that employs class AB input stage and low-noise common mode feedback (CMFB) output stage. The DCR IC was fabricated in a SiGe BiCMOS process and occupies about 2.9mm×3.0mm. The DCR needs SAW filters only for off-chip components and a gain control signal from DBB IC for AGC loop. The IIP3 of over -4.4dBm for small signal input level and that of over +1.9dBm for large signal input level are achieved. The gain compression of the desired signal is less than 0.3dB for ACS Case-II condition.
Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus (2020)

Respiratory syncytial virus (RSV) is a seasonal virus that infects the lungs and airways of 64 million children and adults every year. It is a major cause of acute lower respiratory tract infection and is associated with significant morbidity and mortality. Despite the large medical and economic burden, treatment options for RSV-associated bronchiolitis and pneumonia are limited and mainly consist of supportive care. This publication covers the medicinal chemistry efforts resulting in the identification of JNJ-53718678, an orally bioavailable RSV inhibitor that was shown to be efficacious in a phase 2a challenge study in healthy adult subjects and that is currently being evaluated in hospitalized infants and adults. Cocrystal structures of several new derivatives helped in rationalizing some of the structure–activity relationship (SAR) trends observed.
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. (1985)

Human KB carcinoma cells were selected in sequential steps for resistance to colchicine and found to be cross-resistant to multiple drugs, including vinblastine, adriamycin, and actinomycin D. Compared with the parental line, the multiply resistant cells have decreased amounts of two [35S]methionine-labeled proteins with apparent molecular masses of 75 and 72 kDa. These proteins reappear in a revertant, drug-sensitive cell line. Both proteins are labeled with [14C]glucosamine and are retained on a wheat germ agglutinin-agarose column, indicating that they are glycoproteins. These data suggest that in this human cell line, these two glycoproteins can serve as a marker of the multiple drug-resistance phenotype and may play a role in its etiology.
321 Impact of CDK4/6 inhibitor-induced cellular senescence on stromal responses to breast cancer (2022)

OBJECTIVES/GOALS: The objective of my study is to test my overall hypothesis that CDK4/6 inhibitor-induced cellular senescence has long-lasting consequences on the tumor microenvironment that affect tumor growth and disease progression. METHODS/STUDY POPULATION: There is a lack of mechanistic understanding of the crosstalk of drug effects on different cellular pathways. One less-studied consequence of CDK4/6 inhibitors (CDKI) is their ability to induce cellular senescence in the non-malignant host cells (“stroma”), which causes secretion of a plethora of proteins that have lasting effects on the tumor microenvironment. Stromal cells are known to be able to enter senescence and promote a state of chronic inflammation that contributes to disease progression. I propose to study the stromal contribution to the tumor microenvironment and how this affects tumor growth and disease progression by using genetically engineered mouse models of breast cancer. RESULTS/ANTICIPATED RESULTS: We have found that palbociclib, a CDKI, inhibited growth and induced senescence of breast cancer cell lines xenografted into mice, and that while most on-target effects of palbociclib were reversed after treatment cessation, there was long-lasting down-regulation of interferon-Î³ and inflammatory response signaling pathways in the mouse host stroma that persisted after cessation of palbociclib treatment. In syngeneic models, we have found that palbociclib treatment influenced migration of T cells into CDKI-resistant tumors. DISCUSSION/SIGNIFICANCE: These studies will shed light on how senescence-inducing anticancer therapies, such as CDKI, affect tumor growth and disease progression. My studies will help elucidate new therapeutic avenues in combination with CDKI to combat therapeutic resistance in advanced breast cancer.
Low Pressure CVD of Silicon Nitride (1987)

A model of the hot wall tubular reactor for low pressure chemical vapor deposition (LPCVD) is applied to the study of silicon nitride film growth from dichlorosilane and ammonia. The model predicts the effects of process conditions and reactor configuration on distributed wafer growth rate profiles. The model formulation includes contributions from convection, multicomponent diffusion, and gas and surface reactions of several chemical species. Rival chemical mechanisms are compared to experimental data obtained in a conventional LPCVD reactor over widely varying conditions. Results indicate that the in‐wafer film thickness nonuniformities may be explained by the effect of diffusion‐limited film growth from highly reactive gas‐phase intermediates, with simultaneous uniform deposition from less reactive dichlorosilane. Model predictions agree well with experimental data over the composition, pressure, and temperature ranges considered. The model is also used in the design of optimal operating conditions for 100 and 150 mm wafer processes.
Silicon Photonics: Orientation‐Controlled Selective‐Area Epitaxy of III–V Nanowires on (001) Silicon for Silicon Photonics (Adv. Funct. Mater. 30/2020) (2020)

In article number 2002220, Hyunseok Kim and co-workers demonstrate a method to monolithically integrate III–V nanowires on silicon (001) platforms with the ability to control the position and orientation. The nanowire-based ultracompact photonic crystal cavities are integrated on standard silicon photonic platforms with waveguides, which provides new opportunities in combining functional III–V devices with mature silicon platforms for future nanophotonics and electronics.
Two-dimensional solid-state proton NMR and proton exchange (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional solid-state proton NMR and proton exchangeLing Zheng, Kenneth W. Fishbein, Robert G. Griffin, and Judith HerzfeldCite this: J. Am. Chem. Soc. 1993, 115, 14, 6254–6261Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ja00067a045https://doi.org/10.1021/ja00067a045research-articleACS PublicationsRequest reuse permissionsArticle Views582Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of a crossbar multiplexer in a lithography-based nanowire technology (2011)

Silicon Nanowire technology has been demonstrated to be a promising candidate to fabricate nanowire crossbars. The use of such devices in a real architectural as well as in a design environment is an ongoing research topic. In this paper, we investigate the use of a lithography-based industrial process for designing a 4-to-1 multiplexer in a crossbar circuit. We show that by considering the line parasitic, the crossbar demonstrates poor performance in a 65-nm technology, while the area and power savings are about 6× and 1.5× respectively vs. the CMOS implementation. However, extrapolation to the 9-nm node shows a 2× better performance and 67× area saving.
Effects of particle diameter and magnetocrystalline anisotropy on magnetic relaxation and magnetic particle imaging performance of magnetic nanoparticles (2019)

The dynamic magnetization of immobilized spherical single-domain magnetic nanoparticles (MNPs) with uniaxial or cubic magnetocrystalline anisotropy was studied computationally by executing simulations based on the Landau-Lifshitz-Gilbert (LLG) equation. For situations when a static magnetic field was suddenly applied and then removed, the effects of particle diameter and anisotropy (considering both type of symmetry and characteristic energy) on the characteristic magnetic relaxation time were studied parametrically. The results, for both anisotropy symmetries, show that when a static magnetic field is suddenly turned on or off the MNPs undergo a successive two-step or combined one-step relaxation. Whether a MNP relaxes with one or two steps when the field is turned on is determined by the competition between the energy of the applied magnetic field, the magnetic anisotropy energy, and thermal energy. When the applied magnetic field is suddenly turned off, our results show good agreement with theoretical predictions for the cases of [Formula: see text] and [Formula: see text], where [Formula: see text] represents the magnetic anisotropy energy barrier, [Formula: see text] is the Boltzmann constant and [Formula: see text] represents the absolute temperature. For the case of an applied alternating magnetic field (AMF) that is typical of magnetic particle imaging (MPI) applications, the effects of particle diameter and anisotropy symmetry were studied in terms of time-domain magnetization dynamics, dynamic hysteresis loops, harmonic spectra, and x-space point spread functions (PSFs). Results illustrate that the type of magnetocrystalline anisotropy (uniaxial versus cubic) has a significant effect on the MPI performance of the nanoparticles. These computational studies provide insight into the role of particle diameter and magnetic anisotropy on the performance of MNPs for applications in magnetorelaxometry and MPI.
Geregelte arbeitsteilige Anwendungssysteme (1993)

ZusammenfassungDie im vorangegangenen Kapitel beschriebene Fallstudie stellt ein konkretes Beispiel eines geregelten arbeitsteiligen Anwendungssystems dar. In diesem Kapitel wird die Fallstudie im Hinblick auf geregelte arbeitsteilige Anwendungssysteme generell interpretiert. Es wird zunächst eine Begriffsdefinition für die geregelten arbeitsteiligen Anwendungssysteme als Problemstellung dieser Arbeit vorgenommen, um im weiteren Verlauf von einer Klasse von zu unterstützenden Anwendungssystemen ausgehen zu können. Daran anschließend wird auf spezielle Anforderungen an einen Systemmechanismus zur Unterstützung dieser Anwendungsklasse und die Nutzeffekte eines solchen Mechanismus eingegangen. Das Kapitel schließt mit einer Abgrenzung der geregelten arbeitsteiligen Anwendungssysteme von anderen Formen arbeitsteüiger Anwendungsysteme, die in der Literatur häufig auch als kooperative Anwendungssysteme bezeichnet werden.
Development of Commercially Viable Compliant Mechanisms Using the Pseudo-Rigid-Body Model: Case Studies of Parallel Mechanisms (2001)

Abstract Analysis and synthesis of compliant mechanisms has recently been the subject of significant study in the research community. This focus has led to a number of design approaches for developing compliant mechanisms. This paper describes the value of using the Pseudo-Rigid-Body Model (PRBM) to design compliant mechanisms for commercial products. Application of the PRBM is illustrated through the development of two parallel mechanisms: a bicycle derailleur and parallel-motion bicycle brakes. The PRBM allows compliant mechanisms to be modeled and analyzed as rigid-body mechanisms and significantly reduces the complexity of analysis. Mechanisms with straightforward properties are used to demonstrate the use of the PRBM to design commercially viable compliant mechanisms for required motion and force-deflection characteristics.
Use of following current mirrors in designing high performance BiCMOS transconductance amplifiers and buffers (1992)

MOS current mirrors have been discussed in many papers but most of the discussion usually revolves around output impedance, the effect of channel length, cascoding, etc. In many cases frequency response is important, so the authors look at what factors influence this and what the trade offs are. They refer to data taken from simple two transistor PMOS current mirrors.
Expression of pro-inflammatory genes in human endothelial cells: Comparison of rivaroxaban and dabigatran (2016)

In HUVECs, plasma-induced transcriptional changes are mediated by thrombin-induced PAR-1 activation. Rivaroxaban downregulated the expression of pro-inflammatory markers and tissue factor to a similar extent to dabigatran.
R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice (2023)

RSPO3/LGR4 signaling plays a critical role in regulating TLR-induced inflammation and neurite outgrowth in the ischemic brain. Enhancing this signal will be a promising approach for treating ischemic stroke.
Dark-field imaging on a clinical CT system: modelling of interferometer vibrations (2022)

X-ray computed tomography (CT) is an invaluable imaging technique for non-invasive medical diagnosis. However, for soft tissue in the human body the inherent small difference in attenuation limits its significance. Grating-based X-ray phase-contrast is a relatively novel imaging method which detects additional interaction mechanisms between photons and matter, namely refraction and small-angle scattering, to generate additional images with different contrast. The experimental setup involves a Talbot-Lau interferometer whose susceptibility to mechanical vibrations hindered acquisition schemes suitable for clinical routine in the past. We present a processing pipeline to identify spatially and temporally variable fluctuations occurring in the first interferometer installed on a continuously rotating clinical CT gantry. The correlations of the vibrations in the modular grating setup are exploited to identify a small number of relevant vibration modes, allowing for an artifact-free reconstruction of a sample.
Performance blends based on recycled polymers (1995)

Abstract The recent growth in the post‐consumer recycling of plastics presents an opportunity for developing new, value‐added blend products from the recycled polymers. However, in order to develop blends with useful performance characteristics, suitable techniques of compatibilization and impact modification must be employed. In this study, reactive toughening and compatibilization techniques have been found to be particularly useful in achieving high thermal embrittlement resistance in the blends of recycled poly(ethylene terephthalate) containing functionalized ethylene copolymers and polycarbonate. Reactive compatibilization of recycled polyolefin blends with poly(ethylene terephthalate) and polyamide has also been investigated.
Combined hardware selection and pipelining in high performance data-path design (2002)

Pipelining and hardware selection are important optimization tasks in the design of high-performance data paths. At the highest abstraction level, the specification of a data path consists of a number of interconnected abstract building blocks and a constraint on the minimal required clock frequency. An algorithm which optimally selects hardware blocks from a library for implementing these abstract building blocks is presented, and a technique for hierarchical redistribution and insertion of pipeline registers is described. Finally, both optimization tasks are combined. This combination makes the area tradeoff between additional speed-up circuitry and pipeline registers possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Precision Measurement of Altitude Using Pressure Sensor for Attitude Estimation of UAV (2017)

In this paper, we developed a method of measuring altitude using a MEMS differential pressure sensor (DPS) with a cavity, for an unmanned aerial vehicle (UAV). The method includes modeling of DPS and prevention of the influence by the wind. Firstly, we built a transfer function model of the DPS and measured two parameters required for calculating altitude. The parameters were obtained with two experiments: applying static and dynamic pressure onto the both side of the DPS. Secondly, we developed on the basis of fluid dynamics a shielding cap which protects the sensor chip from direct wind caused by the propellers on a UAV, while keeping it to pursue the static pressure. The most sufficient cap, which is spherical with holes at a specific angle to the wind axis, removed both noise and the dynamic pressure.