gebhart/patrepeval huggingface dataset:
Novel decarbonylation of a formal homoacylpalladium linkage, PdCH(CR:CH2)C(O)SiR'3 affording a PdCH(CR:CH2)SiR'3 moiety (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel decarbonylation of a formal homoacylpalladium linkage, PdCH(CR:CH2)C(O)SiR'3 affording a PdCH(CR:CH2)SiR'3 moietySensuke Ogoshi, Kouichi Ohe, Naoto Chatani, Hideo Kurosawa, Yoshikane Kawasaki, and Shinji MuraiCite this: Organometallics 1990, 9, 12, 3021–3022Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/om00162a008https://doi.org/10.1021/om00162a008research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synchronous AC Homopolar Machines (2011)

This chapter discusses on the simplest configuration of a homopolar synchronous machine. A homopolar machine consists of a superconducting field excitation coil and a conventional poly - phase armature winding. A synchronous homopolar machine offers high power density for operation at speeds of 3600 RPM and higher. The penalty for homopolar flux utilization is compensated by higher air - gap flux densities achieved with superconducting field winding and higher rotor speed. A conventional synchronous machine employs individual superconducting coils for each pole, but a homopolar machine uses only a single field coil with much simpler cryogenic requirements. This enhances reliability of superconducting homopolar machines. Controlled Vocabulary Terms coils; cryogenic electronics; homopolar machines; superconducting materials; synchronous machines
Topographic and electronic structure of cleaved SrTiO3(001) surfaces (2015)

The topographic and electronic structure of cleaved SrTiO3(001) surfaces were studied, employing samples that either had or had not been coated with Ti on their outer surfaces prior to fracture. In both cases, SrO- and TiO2-terminated terraces were present on the cleavage surface, enabling in situ studies on either termination. However, the samples coated with Ti prior to fracture were found to yield a rougher morphology on TiO2-terminated terraces as well as a higher density of oxygen vacancies during an annealing (outgassing) step following the coating. The higher density of oxygen vacancies in the bulk of the Ti-coated samples also provides higher conductivity which, in turn, improves a sensitivity of the spectroscopy and reduces the effect of tip-induced band bending. Nonetheless, similar spectral features, unique to each termination, were observed for samples both with and without the Ti coating. Notably, with moderate-temperature annealing following fracture, a strong discrete peak in the conductance spectra, arising from oxygen vacancies, was observed on the SrO-terminated terraces. This peak appears at slightly different voltages for coated and uncoated samples, signifying a possible effect of tip-induced band bending.
Audio at low and high power (2008)

An overview is presented of recent developments in the analog boundaries of the audio chain. The main focus is on class-D amplifiers that are by now almost standard in consumer applications and emerging in automotive and mobile applications as well. Further, an overview of the state-of-the-art in A/D and D/A conversion is given.
Towards A Model Theory for Distributed Representations. (2014)

Distributed representations (such as those based on embeddings) and discrete representations (such as those based on logic) have complementary strengths. We explore one possible approach to combining these two kinds of representations. We present a model theory/semantics for first order logic based on vectors of reals. We describe the model theory, discuss some interesting properties of such a system and present a simple approach to query answering.
Impaired Assembly Results in the Accumulation of Multiple HLA-C Heavy Chain Folding Intermediates (2005)

Class I MHC H chains assemble with beta2-microglobulin (beta2m) and are loaded with peptide Ags through multiple folding steps. When free of beta2m, human H chains react with Abs to linear epitopes, such as L31. Immunodepletion and coimmunoprecipitation experiments, performed in this study, detected a preferential association of L31-reactive, beta2m-free H chains with calnexin in beta2m-defective cells, and with calreticulin and TAP in beta2m-expressing cells. In beta2m-defective cells, the accumulation of calnexin-bound H chains stoichiometrically exceeded their overall accumulation, a finding that supports both chaperoning preferences and distinct sorting abilities for different class I folds. No peptide species, in a mass range compatible with that of the classical class I ligands, could be detected by mass spectrometry of acidic eluates from L31-reactive HLA-Cw1 H chains. In vitro assembly experiments in TAP-defective T2 cells, and in cells expressing an intact Ag-processing machinery, demonstrated that L31 H chains are not only free of, but also unreceptive to, peptides. L31 and HC10, which bind nearly adjacent linear epitopes of the alpha1 domain alpha helix, reciprocally immunodepleted free HLA-C H chains, indicating the existence of a local un-/mis-folding involving the N-terminal end of the alpha1 domain alpha helix and peptide-anchoring residues of the class I H chain. Thus, unlike certain murine free H chains, L31-reactive H chains are not the immediate precursors of conformed class I molecules. A model inferring their precursor-product relationships with other known class I intermediates is presented.
A dynamic programming approach to trajectory planning of robotic manipulators (1986)

This paper presents a solution to the problem of minimizing the cost of moving a robotic manipulator along a specified geometric path subject to input torque/force constraints, taking the coupled, nonlinear dynamics of the manipulator into account. The proposed method uses dynamic programming (DP) to find the positions, velocities, accelerations, and torques that minimize cost. Since the use of parametric functions reduces the dimension of the state space from <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2n</tex> for an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> - jointed manipulator, to two, the DP method does not suffer from the "curse of dimensionality." While maintaining the elegance of our previous trajectory planning method, we have developed the DP method for the general case where 1) the actuator torque limits are dependent on one another, 2) the cost functions can have an arbitrary form, and 3) there are constraints on the jerk, or derivative of the acceleration. Also, we have shown that the DP solution converges as the grid size decreases. As numerical examples, the trajectory planning method is simulated for the first three joints of the PACS arm, which is a cylindrical arm manufactured by the Bendix Corporation.
Interstitial oxygen molecules in amorphous SiO2. II. The influence of common dopants (SiOH, SiF, and SiCl groups) and fictive temperature on the decay of singlet photoluminescence (2005)

Time decay of photoluminescence due to interstitial oxygen molecules (O2) in synthetic amorphous SiO2(a-SiO2) was studied by varying the fictive temperature and the concentrations of common dopants (SiOH, SiCl, and SiF groups). The decay constant is insensitive to the fictive temperature, but strongly depends on the type of dopants: it is reduced by the nonradiative decay via an energy transfer from O2 to the vibrational modes of the dopants. The increases in the nonradiative decay rate due to SiOH, SiF, and SiCl groups are strong, slight, and negligible, respectively, which correlates with their vibrational energies. The quantum yield decreases by ∼20% as the SiOH content increases from 1017 to 1020cm−3. The deviation from the single exponential decay is due to the shape variation in the a-SiO2 network cages that surround O2, and to the distance distribution between O2 and SiOH groups.
Systematic Design Principles for Cost-Effective Hard Constraint Management in Dynamic Nonlinear Systems (2011)

Modern cost-conscious dynamic systems incorporate knobs that allow run-time trade-offs between system metrics of interest. In these systems regular knob tuning to minimize costs while satisfying hard system constraints is an important aspect. Knob tuning is a combinatorial constrained nonlinear dynamic optimization problem with uncertainties and time-linkage. Hiding uncertainties under worst-case bounds, reacting after the fact, optimizing only the present, and applying static greedy heuristics are widely used problem simplification strategies to keep the design complexity and decision overhead low. Applying any of these will result in highly sub-optimal system realizations in the presence of nonlinearities. The more recently introduced System Scenarios methodology can only handle limited form of dynamics and nonlinearities. Existing predictive optimization approaches are far from optimal as they do not fully exploit the predictability of the system at hand. To bridge this gap, the authors propose the combined strategy of dynamic bounding and proactive system conditioning for the predicted likely future. This paper describes systematic principles to design low-overhead controllers for cost-effective hard constraint management. When applied to fine-grain performance scaling mode assignment problem in a video decoder design, proposed concepts resulted in more than 2x energy gains compared to state-of-the-art techniques.
Adjunctive Rifampin Therapy For Diabetic Foot Osteomyelitis in the Veterans Health Administration (2019)

In this cohort study, patients administered rifampin experienced lower rates of death and amputation than patients not treated with rifampin, which remained significant after adjustment for confounders. These results coupled with existing evidence from small clinical trials suggest the addition of rifampin to current treatment regimens may be a useful antimicrobial option in the treatment of DFO.
Demonstration of a compact low-power 250-Gb/s parallel-WDM optical interconnect (2004)

In this letter, we demonstrate error-free operation of a 12-fiber /spl times/4-wavelength /spl times/5.21-Gb/s parallel-wavelength-division-multiplexed (PWDM) optical link. The 250-Gb/s transmitter and receiver assemblies each have a 5/spl times/8-mm footprint and consume a combined power of 1.5 W. To our knowledge, this is the first publication of a fully functional PWDM optical interconnect as well as the highest demonstrated bandwidth per unit area and bandwidth per unit power consumption for any multiple-channel fiber-optic interconnect. This technology is intended for short-distance high-bandwidth-density applications such as multiprocessor computer backplanes.
Enantioselective Olefin Hydrocyanation Without Cyanide (2019)

The enantioselective hydrocyanation of olefins represents a conceptually straightforward approach to prepare enantiomerically enriched nitriles. These, in turn, comprise or are intermediates in the synthesis of many pharmaceuticals and their synthetic derivatives. Herein, we report a cyanide-free dual Pd/CuH-catalyzed protocol for the asymmetric Markovnikov hydrocyanation of vinyl arenes and the anti-Markovnikov hydrocyanation of terminal olefins in which oxazoles function as nitrile equivalents. After an initial hydroarylation process, the oxazole substructure was deconstructed using a [4+2]/retro-[4+2] sequence to afford the enantioenriched nitrile product under mild reaction conditions.
ChemInform Abstract: Synthesis of Furanosyl C‐1 Glycals Through Palladium‐Catalyzed Reactions of a Furanosyl 2,3‐Anhydro‐exo‐glycal. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results (2007)

These data provide justification for the recently proposed clinical classification system to be used in patients who present with a first episode suggestive of MS, in that ;multifocal', based on symptoms and signs, is associated with more lesions on MRI.
Necklace High Harmonic Generation for Low-Divergence, Soft X-Ray Harmonic Combs with Tunable Line Spacing (2021)

By driving high-harmonics with necklace laser beams, we produce combs with tunable frequency content and spacing, up to the soft x-ray region. The emitted harmonics also exhibit distinct spatial profiles and lower divergence than Gaussian-driven harmonics.
Reducing metal-ion mediated adsorption of acidic peptides in RPLC-based assays using hybrid silica chromatographic surfaces (2021)

In this study we evaluate column hardware exhibiting a novel hybrid silica surface in its ability to mitigate metal-induced adsorption artifacts such as chromatographic peak tailing for acidic amino acid residue containing peptides. Using a conventional reversed-phase liquid chromatography (RPLC)-based method, chromatographic performance of a peptide map was compared using a traditional stainless-steel column and an equivalent column bearing a novel hybrid silica surface. Tailing factors for six peptides containing acidic amino acid residues (T<sub>f</sub> ≥ 1.50) were observed to be reduced up to 80% to a nominal value T<sub>f</sub> ≤ 1.2 with R.S.D. % ≤ 4%. Furthermore, recovery for two of the identified peptides exhibited increased recovery in addition to reduced peak tailing when using the column bearing the hybrid silica surface. Performance was unaffected for peaks where there were no implications of metal induced effects. Collectively, this study demonstrates that the novel hybrid silica surface can effectively reduce peak tailing for acidic residue containing peptides.
Quantum random number generator using a microresonator-based Kerr oscillator (2016)

We demonstrate an all-optical quantum random number generator using a dual-pumped degenerate optical parametric oscillator in a silicon nitride microresonator. The frequency-degenerate bi-phase state output is realized using parametric four-wave mixing in the normal group-velocity dispersion regime with two nondegenerate pumps. We achieve a random number generation rate of 2 MHz and verify the randomness of our output using the National Institute of Standards and Technology Statistical Test Suite. The scheme offers potential for a chip-scale random number generator with gigahertz generation rates and no postprocessing.
Temperature Dependent Raman Spectra of Carbon Nanobuds (2010)

Carbon nanobuds (CNBs) represent an emerging nanostructure, in which fullerene molecules are covalently bonded to the outer surface of single-walled carbon nanotubes (SWNTs). The Raman spectra of CNBs were systematically investigated and compared to those of SWNTs. The spectra were recorded using a 514 nm laser and evaluating the temperature-dependent Raman frequency shift in CNBs in the range 27−475 °C. The temperature coefficient of the G-mode frequency of the CNBs was much larger than that of the SWNTs. Consequently, the CNBs have lower thermal stability, which is attributed to the fact that the fullerenes are covalently bonded to the sidewall of SWNTs. At the same time, we observed that the radical breathing modes (RBMs) of CNBs downshift ∼2−6 cm−1 compared to the RBMs of SWNTs, and this shift can be attributed to the smaller van der Waals (VDWs) interactions between the CNBs. Using a 750 nm laser, a broad G− band, which is an intrinsic character of metallic properties, was clearly observed. This characteristic feature provides evidence that the nanobuds of some nanotubes remain metallic.
Marine natural products as modulators of nuclear receptors (2012)

Nuclear receptors (NRs) represent one of the most important drug targets in terms of potential therapeutic application, playing a role in every aspect of development, physiology and disease in humans. In recent years many natural products were found to act as ligands for NRs. As consequence of our long standing interest in the chemistry of bioactive marine products, we found that some new natural products were endowed with modulatory activity towards FXR, PXR and PPARγ receptors. The chemistry and the biological activity of these modulators will be discussed.
Precipitation of spinally mediated withdrawal signs by intrathecal administration of naloxone and the mu-receptor antagonist CTP in morphine-dependent mice. (1988)

We evaluated the ability of naloxone and the mu receptor antagonist CTP (D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2) to precipitate withdrawal in morphine-dependent mice after intrathecal (i.t.) administration. The withdrawal syndromes elicited by naloxone and CTP given i.t. were compared to those of CTP or naloxone injected intracerebroventricularly (i.c.v.). When given i.t. or i.c.v., naloxone produced the classical syndrome of events including jumping, wet dog shakes, urination, defecation followed by diarrhea, and weight loss. There was no significant difference in the potency or efficacy of naloxone when it was given i.t. or i.c.v. The profile of withdrawal effects produced by i.t. CTP resembled that caused by i.c.v. CTP; both were different from that of naloxone. The withdrawal signs seen following both i.t. or i.c.v. CTP included wet dog shakes and defecation. Mice treated with i.t. CTP lost significantly less body weight than those treated with i.c.v. CTP. In addition, i.t. and i.c.v. CTP did not stimulate jumping behaviors or diarrhea. In contrast, while i.c.v. CTP resulted in increased incidence of urination, CTP given i.t. did not. These finding indicate that naloxone given spinally acts on mu receptors to precipitate wet dog shaking and defecation, but acts on other non-mu opioid receptors (i.e. delta and/or kappa) to cause jumping, urination, diarrhea and weight loss. The differential effects of CTP given i.c.v. or i.t. suggest that supraspinal mu receptors are more involved in gastrointestinal and urinary bladder function during dependence/withdrawal than their spinal counterparts.(ABSTRACT TRUNCATED AT 250 WORDS)
Electrical characteristics of a stacked nitride/microcrystalline-silicon/oxide/silicon structure (1993)

This letter reports a stacked nitride/microcrystalline-silicon/oxide/silicon structure, which exhibits a higher electron injection efficiency, a less electron trapping rate, and a larger charge to breakdown than the normal oxide. Besides, the room-temperature resonant tunneling effect is also observed for this structure.
MHC class II invariant chain–adjuvanted viral vectored vaccines enhances T cell responses in humans (2020)

Strategies to enhance the induction of high magnitude T cell responses through vaccination are urgently needed. Major histocompatibility complex (MHC) class II-associated invariant chain (Ii) plays a critical role in antigen presentation, forming MHC class II peptide complexes for the generation of CD4<sup>+</sup> T cell responses. Preclinical studies evaluating the fusion of Ii to antigens encoded in vector delivery systems have shown that this strategy may enhance T cell immune responses to the encoded antigen. We now assess this strategy in humans, using chimpanzee adenovirus 3 and modified vaccinia Ankara vectors encoding human Ii fused to the nonstructural (NS) antigens of hepatitis C virus (HCV) in a heterologous prime/boost regimen. Vaccination was well tolerated and enhanced the peak magnitude, breadth, and proliferative capacity of anti-HCV T cell responses compared to non-Ii vaccines in humans. Very high frequencies of HCV-specific T cells were elicited in humans. Polyfunctional HCV-specific CD8<sup>+</sup> and CD4<sup>+</sup> responses were induced with up to 30% of CD3<sup>+</sup>CD8<sup>+</sup> cells targeting single HCV epitopes; these were mostly effector memory cells with a high proportion expressing T cell activation and cytolytic markers. No volunteers developed anti-Ii T cell or antibody responses. Using a mouse model and in vitro experiments, we show that Ii fused to NS increases HCV immune responses through enhanced ubiquitination and proteasomal degradation. This strategy could be used to develop more potent HCV vaccines that may contribute to the HCV elimination targets and paves the way for developing class II Ii vaccines against cancer and other infections.
Processing and adjusting the hydrophilicity of poly(oxymethylene) (co)polymers: nanoparticle preparation and film formation (2015)

Handling the insoluble POM: the preparation of organic and aqueous nanoparticle dispersions based on poly(oxymethylene) copolymers and their film formation is described.
Persister cells resuscitate via ribosome modification by 23S rRNA pseudouridine synthase RluD (2019)

Upon a wide range of stress conditions (e.g. nutrient, antibiotic, oxidative), a subpopulation of bacterial cells known as persisters survives by halting metabolism. These cells resuscitate rapidly to reconstitute infections once the stress is removed and nutrients are provided. However, how these dormant cells resuscitate is not understood well but involves reactivating ribosomes. By screening 10,000 compounds directly for stimulating Escherichia coli persister cell resuscitation, we identified that 2-{[2-(4-bromophenyl)-2-oxoethyl]thio}-3-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (BPOET) stimulates resuscitation. Critically, by screening 4267 E. coli proteins, we determined that BPOET activates hibernating ribosomes via 23S rRNA pseudouridine synthase RluD, which increases ribosome activity. Corroborating the increased waking with RluD, production of RluD increased the number of active ribosomes in persister cells. Also, inactivating the small RNA RybB which represses rluD led to faster persister resuscitation. Hence, persister cells resuscitate via activation of RluD.