gebhart/patrepeval huggingface dataset:
A Text Mining based content gathering system as strategic support for SMEs (2006)

The diffusion of innovation culture is an essential condition to guarantee entrepreneurial progress and improvement to the social fabric. Innovation processes in enterprises need constant Research and Development. The majority of Italian Small and Medium Enterprises (SMEs) experience difficulties in keeping in touch with innovations in the research world, which hinders competitiveness growth in actual global markets. FirenzeTecnologia together with Synthema-TEMIS-Focuseek has developed an integrated platform named SPI-RIT ("Services for Enterprises -Research and Technological Innovation"), which is directly oriented to facilitate structured and life-long relationships between the regional industrial world and scientific one. SPI-RIT collects heterogeneous and distributed data, integrating focused crawling, multilingual natural language processing indexing and searching, unsupervised clustering. SPI-RIT advocates and encourages integration between research and industry; promotes the industrial use of research results; increases the technological development of enterprises to support their competitiveness, relying upon a network of contacts with institutions, research institutes and consulting organisations.
Facile synthesis and patterning of silver nanoparticles for surface plasmon generation (2011)

A facile single step strategy for the synthesis and large area patterning of silver nanoparticles via photodecomposition of a photoactive silver nitrite aliphatic amine complex was developed. Decomposition of the silver complex was facilitated using either a UV or an Argon ion laser (514.5 nm) irradiation. The synthesis was performed both in solution and thin films. The silver nanoparticles displayed characteristic localized surface plasmon resonance in the absorption spectrum. Utilizing laser beam interference, silver nanoparticles were synthesized and, as well, patterned in a single step.
Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti‐inflammatory effects through the activation of neurokinin‐1 receptor (2016)

Chronic pruritus is difficult to treat. Current treatment options are frequently ineffective and new therapeutic approaches are urgently needed. Avenanthramides are active substances in oats that exhibit anti-inflammatory effects. Their potential to interrupt pruritus mechanisms was investigated in this study. It was found that the synthetic analog dihydroavenanthramide D (DHAvD) can interact with the neurokinin-1 receptor (NK1R) and inhibit mast cell degranulation. DHAvD also affects inflammatory processes and reduces secretion of the cytokine interleukin-6. Our findings indicate that DHAvD may act as a NK1R inhibitor and could be a promising candidate for topical treatments of chronic pruritus.
Unconventional Bonding of Azafullerenes:  Theory and Experiment (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTUnconventional Bonding of Azafullerenes: Theory and ExperimentWanda Andreoni, Alessandro Curioni, Károly Holczer, Kosmas Prassides, Majid Keshavarz-K., Jan-Cornelis Hummelen, and Fred WudlView Author Information IBM Research Division, Zurich Research Laboratory CH-8803 Rüschlikon, Switzerland Scuola Normale Superiore, I-56126 Pisa, Italy Department of Physics, University of California Los Angeles, California 90024 School of Chemistry, Physics and Environmental Science University of Sussex, Flamer, Brighton BN1 9QJ, U.K. Institute for Polymers and Organic Solids Department of Chemistry and Materials University of California, Santa Barbara, California 93106Cite this: J. Am. Chem. Soc. 1996, 118, 45, 11335–11336Publication Date (Web):November 13, 1996Publication History Received5 July 1996Published online13 November 1996Published inissue 13 November 1996https://doi.org/10.1021/ja962279iCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views393Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (117 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbon,Chemical structure,Dimerization,Nitrogen,Oligomers Get e-Alerts
Tailoring electromagnetically induced transparency for terahertz metamaterials: From diatomic to triatomic structural molecules (2013)

The coupling effects in electromagnetically induced transparency (EIT) for triatomic metamaterials are investigated at terahertz (THz) frequencies both experimentally and theoretically. We observed enhancement and cancellation of EIT with single transparency window, and also two additional ways to achieve double EIT transparency windows. One is from the hybridization between two dark atoms in a bright-dark-dark configuration. Another is from an averaged effect between absorption of the additional bright atom and the EIT from the original diatomic molecule in a bright-bright-dark configuration. It allows us to control EIT and the associated slow-light effect for THz metamaterials with high accuracy. © 2013 AIP Publishing LLC.
Freeze-Dried Heart Valve Scaffolds (2012)

In this study, structure and biomechanical properties of freeze-dried decellularized porcine pulmonary heart valves were investigated. Heart valves were dissected from porcine hearts. The tissues were decellularized and separated in three groups: (1) without lyoprotectant, (2) with 5% sucrose, and (3) with a mixture of 2.5% sucrose and 2.5% hydroxyl ethylene starch (HES), and then underwent freeze-drying. Freeze-drying in the absence of lyoprotectants caused an overall more disintegrated appearance of the histological architecture of the porcine valves, especially between the fibrosa and the ventricularis layers. Freeze-dried tissues with lyoprotectants have a looser network of collagen and elastic fibers with bigger pore sizes. Tissue freeze-dried in the absence of lyoprotecants had the largest pore sizes, whereas the tissue freeze-dried in the presence of protectants showed pores of intermediate sizes between the decellularized tissue and the unprotected freeze-dried samples. Tissue freeze-dried with sucrose alone displayed less porosity than tissue freeze-dried with the sucrose/HES mixture, whereas no significant differences in biomechanical properties were observed. Decellularization decreased the elastic modulus of artery tissue. The elastic modulus of freeze-dried tissue without protectants resembled that of decellularized tissue. The elastic modulus values of freeze-dried tissue stabilized by lyoprotectants were greater than those of decellularized tissue, but similar to those of native tissue.
Figure S6 from Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases (2023)

&lt;p&gt;Supplemental Figure 6. CA-4948 inhibition of MAPK and NF-κB signaling in MBM.&lt;/p&gt;
Few-Mode Multi-Core Fiber Technologies for Repeated Dense SDM Transmission (2018)

We introduce the high spatial density few-mode multi-core fiber (FM-MCF) design for repeated space division multiplexed transmission. We clarify the 6-mode 7-core structure is beneficial for reducing the splice induced differential modal loss, and report the repeated 100-km transmission using our 6-mode MCF and EDFA.
Application of an Advanced CFD-Based Analysis System to the PW6000 Combustor to Optimize Exit Temperature Distribution: Part I — Description and Validation of the Analysis Tool (2001)

This paper is the first of two parts that describes an advanced CFD-based analysis system, developed at Pratt &amp; Whitney, which has been used to optimize the PW6000 combustor exit temperature distribution. It utilizes a CFD calculation through the entire combustor domain to predict temperature distribution at the combustor exit. In this part, all components of the analysis system are presented, including the CAD and grid generation approach used to represent the complex combustor geometry, the core CFD solver, the Lagrangian fuel spray model, and the combustion model. In addition, the predictive capability of the system is established by comparing calculated exit temperature profiles to full annular rig test data for three aircraft gas turbine engine combustors: PW4090, PW4098, and a low-emissions technology development combustor. Comparisons of combustor airflow distribution and pressure drop are also presented to verify the accuracy of the tool. The paper demonstrates that the CFD-based analysis system is capable of calculating exit temperature distribution for a range of combustor configurations, and thus can be utilized as a predictive design tool. Part II demonstrates this predictive capability by applying the analysis tool to optimize the PW6000 combustor exit temperature distribution for turbine durability and life.
Correction to “Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide” (2018)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide"Anna BrezdenAnna BrezdenMore by Anna Brezden, Mohamed F. MohamedMohamed F. MohamedMore by Mohamed F. Mohamed, Manish NepalManish NepalMore by Manish Nepal, John S. HarwoodJohn S. HarwoodMore by John S. Harwood, Jerrin KuriakoseJerrin KuriakoseMore by Jerrin Kuriakose, Mohamed N. SeleemMohamed N. SeleemMore by Mohamed N. Seleemhttp://orcid.org/0000-0003-0939-0458, and Jean Chmielewski*Jean ChmielewskiMore by Jean Chmielewskihttp://orcid.org/0000-0003-4958-7175Cite this: J. Am. Chem. Soc. 2018, 140, 40, 13125–13126Publication Date (Web):September 28, 2018Publication History Published online28 September 2018Published inissue 10 October 2018https://pubs.acs.org/doi/10.1021/jacs.8b09906https://doi.org/10.1021/jacs.8b09906correctionACS PublicationsCopyright © 2018 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2121Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (776 KB) Get e-Alertsclose Get e-Alerts
Variability of Serum Phosphate in Incident Hemodialysis Patients: Association with All-Cause Mortality (2023)

Key Points An increase in serum phosphate variability is an independent risk factor of mortality. The effects of a positive directional range (DR) is most pronounced in patients with high serum phosphate levels whereas the effects of a negative DR is most pronounced in patients with low serum phosphate and/or serum albumin. Background In maintenance hemodialysis (HD) patients, previous studies have shown that serum phosphate levels have a bidirectional relation to outcome. Less is known about the relation between temporal dynamics of serum phosphate in relation to outcome. We aimed to further explore the relation between serum phosphate variability and all-cause mortality. Methods All adult incident HD patients treated in US Fresenius Kidney Care clinics between January 2010 and October 2018 were included. Baseline period was defined as 6 months after initiation of HD and months 7–18 as follow-up period. All-cause mortality was recorded during the follow-up period. The primary metric of variability used was directional range (DR) that is the difference between the largest and smallest values within a time period; DR was positive when the smallest value preceded the largest and negative otherwise. Cox proportional hazards models with spline terms were applied to explore the association between phosphate, DR, and all-cause mortality. In addition, tensor product smoothing splines were computed to further elucidate the interactions of phosphate, DR, and all-cause mortality. Results We included 302,613 patients. Baseline phosphate was 5.1±1.2 mg/dl, and mean DR was +0.6±3.3 mg/dl. Across different levels of phosphate, higher levels of DR of phosphate were associated with higher risk of all-cause mortality. In patients with lower levels of phosphate and serum albumin, the effect of a negative DR was most pronounced, whereas in patients with higher phosphate levels, a positive DR was related to increased mortality. Conclusions Higher variability of serum phosphate is related to mortality at all levels of phosphate, especially in lower levels with a negative DR and in low serum albumin levels. This could possibly reflect dietary intake in patients who are already inflamed or malnourished, where a further reduction in serum phosphate should prompt for nutritional evaluation.
Magneto-mechanical analysis of magnetic gear pole pieces ring from analytical models for wind turbine applications (2018)

This article deals with the structural behavior of a multi-bar system which maintains pole pieces in a concentric magnetic gear. Simplified analytic magnetic and mechanical models of the system are proposed in order to be integrated in a multi-criteria global optimization for the sizing of a magnetic gear in wind power applications. For this purpose, the reduction of the computation time is taken into account. The geometry of the support bar subsystem is defined and a Q bar structure is proposed. The magnetic study is based on Maxwell’s equations and subdomain method in order to determine variable radial and tangential magnetic loads. The mechanical study is based on a multibody model with different bars stiffnesses which are determined from a one-dimensional model. Variable radial and tangential magneto-mechanical pole pieces loads (magnetic load and weight) are also considered. An example of a magnetic gear with 172 pole pieces (i.e. 6-MW wind turbine) is proposed to analyze the mechanical behavior and also the computation time.
USE OF POLYMERS IN HIGHWAY BRIDGE SLABS (1976)

One approach to dealing with the problem of bridge deck deterioration is to seal the macrocracks, micropores and microcapillaries of the concrete layer above the reinforcing steel with an impermeable solid substance that would prevent penetration of salt solution, for example, by incorporating a low-melting wax or by polymer impregnation. The paper discusses a large-scale field test conducted on a bridge to determine the feasibility and effectiveness of polymers in dealing with the problem, methods and apparatus for field impregnation, and other aspects of the problem.
Fabrication and characterization of focused-ion-beam trimmed write heads for perpendicular magnetic recording (2002)

A focused ion beam (FIB) has been used to trim write heads for perpendicular magnetic recording using untrimmed HGA-level longitudinal heads. The ion-beam imaging of the write head during FIB processing was minimized to limit exposure of the active magnetic material at the ABS to a 30 keV Ga+ ion dose of less than 1014 Ga+/cm2 (≈10−13 C/μm2) (the GMR reader was never exposed), which is significantly below levels where magnetic properties have been observed to degrade [W. M. Kaminsky et al., Appl. Phys. Lett. 78, 1589 (2001)]. The corresponding recording characteristics and spatial profiles of written tracks have been measured on a spin stand and a magnetic force microscope (MFM). Recording performance, such as SNR, and pulse shape of transitions, for example, as a function of head design and FIB processing is discussed, which compares very favorably to the performance of untrimmed heads. The MFM images reveal curvature in the magnetic transitions (transition smile) when writing with a single-pole writer with a straight trailing edge. Conversely, we demonstrate straight transitions using a single-pole writer with a curved trailing edge. Our results demonstrate the robustness of FIB-trimmed heads down to sub-100-nm length scales.
Interactive Illumination Invariance (2015)

Illumination effects cause problems for many computer vision algorithms. We present a user-friendly interactive system for robust illumination-invariant image generation. Compared with the previous automated illumination-invariant image derivation approaches, our system enables users to specify a particular kind of illumination variation for removal. The derivation of illumination-invariant image is guided by the user input. The input is a stroke that defines an area covering a set of pixels whose intensities are influenced predominately by the illumination variation. This additional flexibility enhances the robustness for processing non-linearly rendered images and the images of the scenes where their illumination variations are difficult to estimate automatically. Finally, we present some evaluation results of our method.
Downregulation of Glycosyltransferase a Expression By miRNA-331-3p Is Mediated By the Inhibition of the Transcription Factor SP1 (2016)

Abstract More than 100 ABO subgroup-related variations were detected in the coding region of glycosyltransferases, which may be causative for a weak blood group antigen A or B expression. Most variation in expression is explained genetically by mutations that reduce transferase activity. However, a substantial number of weak variants have not yet been explained by current methods. We recently postulated a role of miRNA in the regulation of blood group A antigen expression levels. By using different approaches, including gene array analysis, luciferase reporter assay and overexpression of glycosyltransferase specific miRNAs in primary hematopoietic stem cells (HSCs), we found that miR-331-3p directly targets glycosyltransferase A and B mRNA. Now we have been further embarking on the underlying mechanisms of miRNA and glycosyltransferase interactions and show that the effects of miR-331-3p are mediated by inhibition of transcription factor SP1, which is a major regulator of the ABO gene, thereby resulting in downregulation of blood group A antigen expression in A2O individuals by up to 80% and in A1O individuals by up to 50%. Using microRNA target prediction tools we also identified Sp1 as a potential target gene for miR-331-3p. Western blot analyses of glycosyltransferase protein expression showed that overexpression of miR-331 led to a decreased glycosyltransferase and SP1 protein expression. Further approaches with the SP1 inhibitor, mithramycin A, revealed similar results. Analysis of Aw04/O1v genotypes revealed elevated miRNA levels, thus confirming microRNAs as regulators of blood group glycosyltransferase expression. Our findings extend our understanding of blood group regulation in carriers of weak blood group variants. Involvement of miRNAs in the downregulation of ABO blood group antigen expression may also provide an explanation for observed changes of ABO antigen expression in abnormal processes such as tumorigenesis, pregnancy and aging. Furthermore, this pathway may play a role in the regulation of other blood group variants (for instance Rhesus, KELL, amongst others). Disclosures No relevant conflicts of interest to declare.
The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering (2014)

Solution structures and biochemical data have provided a wealth of mechanistic insight into Ras GTPases. However, information on how much the membrane organization of these lipid-modified proteins impacts on their signaling is still scarce. Ras proteins are organized into membrane nanoclusters, which are necessary for Ras-MAPK signaling. Using quantitative conventional and super-resolution fluorescence methods, as well as mathematical modeling, we investigated nanoclustering of H-ras helix α4 and hypervariable region mutants that have different bona fide conformations on the membrane. By following the emergence of conformer-specific nanoclusters in the plasma membrane of mammalian cells, we found that conformers impart distinct nanoclustering responses depending on the cytoplasmic levels of the nanocluster scaffold galectin-1. Computational modeling revealed that complexes containing H-ras conformers and galectin-1 affect both the number and lifetime of nanoclusters and thus determine the specific Raf effector recruitment. Our results show that mutations in Ras can affect its nanoclustering response and thus allosterically effector recruitment and downstream signaling. We postulate that cancer- and developmental disease-linked mutations that are associated with the Ras membrane conformation may exhibit so far unrecognized Ras nanoclustering and therefore signaling alterations.
Graphene: Evidence for Edge‐State Photoluminescence in Graphene Quantum Dots (Adv. Funct. Mater. 40/2013) (2013)

The cover depicts a high-resolution transmission electron image of a graphene quantum dot. Graphene quantum dots exhibit strong photoluminescence in the visible spectral region. This photoluminescence is investigated by A. M. Rao and co-workers on page 5062, who determine that it stems from their edge states. They can be used in a wide range of applications ranging from biomedical imaging to energy-related devices. Artwork by Dr. Robert Johnson.