gebhart/patrepeval huggingface dataset:
NUCLEAR RADIATION ENHANCEMENT OF CO$sub 2$ LASER PERFORMANCE. (1972)

and thermal tests before CO2 injection, (2) joint inversion tools for updating the geologic model with the distribution of rock properties, thus reducing uncertainty, using hydro-geophysical monitoring data, and (3) highly efficient algorithms for directly solving the dense or sparse linear algebra systems derived from the joint inversion. The system combines methods from stochastic analysis, fast linear algebra, and high performance computing. The developed joint inversion tools have been tested through synthetic CO2 storage examples.
Accelerating business analytics applications (2012)

Business text analytics applications have seen rapid growth, driven by the mining of data for various decision making processes. Regular expression processing is an important component of these applications, consuming as much as 50% of their total execution time. While prior work on accelerating regular expression processing has focused on Network Intrusion Detection Systems, business analytics applications impose different requirements on regular expression processing efficiency. We present an analytical model of accelerators for regular expression processing, which includes memory bus-, I/O bus-, and network-attached accelerators with a focus on business analytics applications. Based on this model, we advocate the use of vector-style processing for regular expressions in business analytics applications, leveraging the SIMD hardware available in many modern processors. In addition, we show how SIMD hardware can be enhanced to improve regular expression processing even further. We demonstrate a realized speedup better than 1.8 for the entire range of data sizes of interest. In comparison, the alternative strategies deliver only marginal improvement for large data sizes, while performing worse than the SIMD solution for small data sizes.
Optimized Network Slicing Proof-of-Concept with Interactive Gaming Use Case (2020)

Network Operators expect to accurately satisfy a wide range of user's needs by providing fully customized services relying on Network Slicing. The efficiency of Network Slicing depends on an optimized management of network resources and Quality of Service (QoS). We focus on Network Slice placement optimization problem to give an insight about a latency-aware Network Slice Placement model through a Proof-of-Concept (PoC) illustrated by an Interactive Gaming time-sensitive use case. Therefore, we showcase the proposed Network Slice Placement solution considering user location as a primary constraint to ensure QoS and Quality of Experience (QoE).
Uncalibrated Eye-in-Hand Visual Servoing (2003)

In this paper we present new uncalibrated control schemes for vision-guided robotic tracking of a moving target using a moving camera. These control methods are applied to an uncalibrated robotic system with eye-in-hand visual feedback. Without a priori knowledge of the robot's kinematic model or camera calibration, the system is able to track a moving object through a variety of motions and maintain the object's image features in a desired position in the image plane. These control schemes estimate the system Jacobian as well as changes in target features due to target motion. Four novel strategies are simulated and a variety of parameters are investigated with respect to performance. Simulation results suggest that a Gauss-Newton method utilizing a partitioned Broyden's method for model estimation provides the best steady-state tracking behavior.
Figure S7 from Nanoconjugation of PSMA-Targeting Ligands Enhances Perinuclear Localization and Improves Efficacy of Delivered Alpha-Particle Emitters against Tumor Endothelial Analogues (2023)

&lt;p&gt;Effect of flow field on viability of PSMA-positive HUVEC as a function of delivered radioactivity per cell.&lt;/p&gt;
Fast Simplified Successive-Cancellation List Decoding of Polar Codes (2017)

Polar codes are capacity achieving error correcting codes that can be decoded through the successive-cancellation algorithm. To improve its error-correction performance, a list-based version called successive-cancellation list (SCL) has been proposed in the past, that however substantially increases the number of time-steps in the decoding process. The simplified SCL (SSCL) decoding algorithm exploits constituent codes within the polar code structure to greatly reduce the required number of time-steps without introducing any error-correction performance loss. In this paper, we propose a faster decoding approach to decode one of these constituent codes, the Rate-1 node. We use this Rate-1 node decoder to develop Fast-SSCL. We demonstrate that only a list-size-bound number of bits needs to be estimated in Rate-1 nodes and Fast-SSCL exactly matches the error-correction performance of SCL and SSCL. This technique can potentially greatly reduce the total number of time-steps needed for polar codes decoding: analysis on a set of case studies show that Fast-SSCL has a number of time- steps requirement that is up to 66.6% lower than SSCL and 88.1% lower than SCL.
Development of Novel Tools for the Diagnosis and Prognosis of Pheochromocytoma Using Peptide Marker Immunoassay and Gene Expression Profiling Approaches (2006)

Pheochromocytomas (PHEOs) are rare catecholamine-producing neoplasias that arise from chromaffin cells of the adrenal medulla or from extra-adrenal locations. These neuroendocrine tumors are usually benign, but may also present as or develop into a malignancy. There are currently no means to predict or to cure malignant tumors which have a poor prognosis. We have recently validated several assays for the measurement of peptides derived from chromogranin A (CgA) and secretogranin II (SgII) in order to determine whether these secreted neuroendocrine products could provide useful, complementary markers for the diagnosis and prognosis of PHEOs. Both the CgA-derived peptide WE14 and the SgII-derived peptide EM66 proved to be sensitive circulating markers for the diagnosis of PHEO. In addition, much higher EM66 levels were measured in benign than in malignant tumoral tissues, suggesting that this peptide could represent a valuable tool for the prognosis of PHEO. We have also initiated a comparative microarray study of benign and malignant PHEOs, which allowed the identification of a set of about 100 genes that were differentially expressed and best discriminated the two types of tumors. A large majority of these genes were expressed at lower levels in the malignant disease and were associated with various characteristics of chromaffin cells, such as hormone secretion signaling and machinery, peptide maturation, and cellular morphology. Altogether, these studies provide novel tools for the management of PHEO, and new insights for the understanding of tumorigenesis in chromaffin cells, which may offer potential therapeutic strategies.
Non-contact quantitative diffuse reflectance spectroscopy (2015)

We validate a non-contact Diffuse Reflectance Spectroscopy (DRS) system as a first stage to approach quantitative multi-spectral imaging technique. The non-contact DRS system with separated illumination and detection paths was developed with different progressive set-ups which were all compared to a well-founded contact DRS system. While quantitation of the absorption coefficient is well achieved with the existing method, the calculation of the scattering coefficient is deteriorated by the non-contact architecture measurements. We have therefore developed an adaptive reference-based algorithm to compensate for this effect.
Nanoionic memristive phenomena in metal oxides: the valence change mechanism (2021)

This review addresses resistive switching devices operating according to the bipolar valence change mechanism (VCM), which has become a major trend in electronic materials and devices over the last decade due to its high potential for non-volatile memories and future neuromorphic computing. We will provide detailed insights into the status of understanding of these devices as a fundament for their use in the different fields of application. The review covers the microscopic physics of memristive states and the switching kinetics of VCM devices. It is shown that the switching of all variants of VCM cells relies on the movement of mobile donor ions, which are typically oxygen vacancies or cation interstitials. VCM cells consist of three parts: an electronically active electrode (AE), often a metal with a high work function, in front of which the switching occurs, a mixed ionic-electronic conducting (MIEC) layer consisting of a nanometer-scale metal oxide or a stack of different metal oxides, and an ohmic counter electrode (OE). After an introduction to definitions and classification, the fundamentals of solid-state physics and chemistry associated with VCM cells are described, including redox processes and the role of electrodes. The microscopic changes induced by electroforming, a process often required prior to resistive switching, are described in terms of electronic initialization and subsequent changes in chemistry, structure, and conductivity. The switching process is discussed in terms of switching polarity, geometry of the switching region, and spectroscopic detection of the valence changes. Emphasis is placed on the extreme nonlinearity of switching kinetics described by physics-based multiscale modeling, ranging from ab initio methods to kinetic Monte Carlo and finite element models to compact models that can be used in circuit simulators. The review concludes with a treatment of the highly relevant reliability issues and a description of the failure mechanisms, including mutual trade-offs.
Comparison of tissues for tympanoplasty (2019)

Usually the eardrum is reconstructed with autologous fascia, cartilage or perichondrium. These human tissues vary interpersonally in their acousto-mechanical and structural properties. The majority of eardrum defects can be sufficiently closed, but often an air-bone gap (ABG) remains or the perforation reappears. With artificial replacement materials, it is expected that eardrum reconstructions can be performed with consistently good and reproducible results.
Quad Band Digitally Controlled Oscillator for WCDMA Transmitter in 90nm CMOS (2006)

We present the first published implementation and measurements of a fully integrated phase path for a 3G polar transmitter in deep sub micron CMOS. It includes a single quad band digitally controlled oscillator (DCO) providing modulation capability to handle the wide bandwidth of the WCDMA phase (frequency) data and a switched inverter divider. The complete chip, with integrated LDOs, consumes 20mA from a 1.4V supply while providing a PN of -157dBc/Hz at a 40MHz offset for a 2GHz output
Identifying a Minimal Rheological Configuration: A Tool for Effective and Efficient Constitutive Modeling of Soft Tissues (2011)

We describe a modeling methodology intended as a preliminary step in the identification of appropriate constitutive frameworks for the time-dependent response of biological tissues. The modeling approach comprises a customizable rheological network of viscous and elastic elements governed by user-defined 1D constitutive relationships. The model parameters are identified by iterative nonlinear optimization, minimizing the error between experimental and model-predicted structural (load-displacement) tissue response under a specific mode of deformation. We demonstrate the use of this methodology by determining the minimal rheological arrangement, constitutive relationships, and model parameters for the structural response of various soft tissues, including ex vivo perfused porcine liver in indentation, ex vivo porcine brain cortical tissue in indentation, and ex vivo human cervical tissue in unconfined compression. Our results indicate that the identified rheological configurations provide good agreement with experimental data, including multiple constant strain rate load/unload tests and stress relaxation tests. Our experience suggests that the described modeling framework is an efficient tool for exploring a wide array of constitutive relationships and rheological arrangements, which can subsequently serve as a basis for 3D constitutive model development and finite-element implementations. The proposed approach can also be employed as a self-contained tool to obtain simplified 1D phenomenological models of the structural response of biological tissue to single-axis manipulations for applications in haptic technologies.
Direct Bioelectrocatalysis: Oxygen Reduction for Biological Fuel Cells (2014)

Effective redox bioelectrocatalysts are the crux to design and development of the next generation of microscale electrochemical biosensors, biomedical devices, and biological fuel cells (BFCs). This chapter summarizes state-of-the-art concepts, strategies, and methodologies specifically related to the design and development of biological cathodes that demonstrate bioelectrocatalysis via direct electron transfer (DET) during enzyme-catalyzed reduction of oxygen to water. The core of this research area is a fundamental understanding of multicopper oxidases (MCOs), elucidating specific mechanisms of interfacial and intramolecular ET and characterizing the redox properties of MCOs. Laccase from Trametes versicolor, bilirubin oxidase (BOx) from the fungus Myrothecium verrucaria, and ascorbate oxidase (AOx) from Cucurbita sp. are discussed as representative MCOs originating from very different species. The diversity of MCOs has been well studied, not least because the enzymes exhibit excellent catalytic activity, which is beneficial to a number of commercial technologies.
A utilização dos recursos tecnológicos na gestão documental: uma análise do SIPAC-UFPB (2018)

Introdução: A gestão nas instituições públicas está vinculada ao objetivo de atingir a satisfação do cidadão, uma vez que o Estado tem como finalidade de seus atos o interesse público. Objetivo: Analisar as mudanças proporcionadas pela implementação dos Sistemas de Informação na gestão de documentos no setor do Protocolo Geral da Universidade Federal da Paraíba. Metodologia: A pesquisa tem natureza descritiva com abordagem qualitativa, onde foram aplicados questionários com os técnicos/servidores administrativos que trabalhavam no setor. Resultados: A rigor, descrevemos e analisamos algumas das funcionalidades do SIG, com ênfase no módulo protocolo do SIPAC, nas atividades-meio (administrativas) sem deixar de avaliar o desenvolvimento da gestão documental. A pesquisa ressalta a dinâmica de acesso e uso das informações produzidas, da abertura dos processos à gestão documental, considerando o curso das mudanças tecnológicas nos procedimentos, desde o uso de fichas para a representação da informação e a tramitação de processos administrativos, que eram exclusivamente em suporte de papel, até a implementação do Sistema Integrado de Patrimônio, Administração e Contratos, em 2013, a qual possibilitou a descentralização e o acesso mais amplo aos procedimentos administrativos. Conclusões: Identificamos a otimização dos serviços reconfigurados com o sistema híbrido – eletrônico/papel –, como também melhorias no processo de gestão da informação.
Analysis of the Apollo 16 Free-Fluid Electrophoresis Experiment (1976)

Abstract The Apollo 16 free-fluid electrophoresis experiment attempted the separation in microgravity of two different-size monodisperse polystyrene latexes under conditions that would give a completely roiled sample on earth because of the thermal convection. The instrument comprised three parallel 0. 63-cm inside diameter 10. 2-cm long Lexan polycarbonate electrophoresis channels, with ted from the channel by semipermeable membranes. The latex samples were contained in cylindrical chambers separated from the electrode by a fixed semipermeable membrane and from the Lexan tube by a movable Kapton polyimide film. Two channels contained 0. 80μm- and 0. 23μ-diameter monodisperse polystyrene latexes and the third, a mixture of the two sizes. The experiment was initiated in microgravity by removing the Kapton films which separated the latex samples from the electrophoresis channels and applying a potential of 300 volts across the electrodes. The results were recorded by photographs taken every 20 seconds.
Abstract 4819: Sacituzumab Govitecan (IMMU-132) in uterine serous carcinoma (2019)

Abstract Objective: Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer with poor prognosis. Sacituzumab govitecan (IMMU-132) is a novel antibody-drug conjugate (ADC) targeting trophoblast antigen 2 (Trop-2), a cell surface glycoprotein highly expressed in many epithelial tumors including USC, to deliver SN-38, the active metabolite of irinotecan. The objective of this study was to preclinically evaluate the efficacy of IMMU-132 against primary USC cell lines and xenografts. Methods: Trop-2 expression in primary tumor cell lines and USC cell viability after exposure to IMMU-132 ADC (hRS7-CL2A-SN-38), non-targeting control ADC (h679-CL2A-SN-38), and naked antibody hRS7 IgG were evaluated using RT-PCR and flow-cytometry-based-assays. Antibody-dependent-cell-cytotoxicity (ADCC) against Trop-2+ and Trop-2- USC cell lines was evaluated in vitro using 4 hr Chromium release assays. Finally, in vivo activity of Sacituzumab govitecan was tested against Trop-2+ USC xenografts by 3 twice-a-week retro-orbital injection of 500 μg of IMMU-132, control-ADC, and hRS7 naked-IgG. Results: Overexpression of Trop-2 was detected in 67% (8 out of 12) of primary USC cell lines. Primary tumors overexpressing Trop-2 were significantly more sensitive (ie, lower IC50) to IMMU-132 (hRS7-CL2A-SN-38) when compared to control ADC (h679-CL2A-SN-38). Both sacituzumab govitecan (IMMU-132) and the naked antibody hRS7 induced high level of ADCC against Trop2+ USC cell lines while no cytotoxicity was detected against Trop-2 negative tumors. In vivo experiments comparing IMMU-132 activity to control ADC and hRS7 showed a dramatically improved tumor suppression and increased survival in IMMU-132 treated mice when compared to controls (P = 0.0001 and P = 0.0002, respectively). Conclusion: IMMU-132 demonstrated remarkable antitumor activity against biologically aggressive USC overexpressing Trop-2. Our preclinical results combined with the dramatic clinical response recently reported in an USC patient treated with IMMU-132 (https://doi.org/10.1016/j.gore.2018.05.009) strongly supports further clinical development of sacituzumab govitecan in USC patients with advanced/recurrent disease. (ie, clinical trial IND 140394). Furthermore, due to a cleavable linker that can cause bystander effect, sacituzumab govitecan could be also effective in tumors with heterogenous TROP-2 expression. Citation Format: Salvatore Lopez, Chanhee Han, Burak Zeybek, Elena Bonazzoli, Anna Bianchi, Paola Manara, Stefania Bellone, Aranzazu Manzano, Emanuele Perrone, Luca Zammataro, Gary Altwerger, Alessandro D. Santin. Sacituzumab Govitecan (IMMU-132) in uterine serous carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4819.
A Comparison of PHY Layer on the Ecma-392 and IEEE 802.11af Standards (2012)

Cognitive radio is widely expected to be a promising technology to efficiently exploit underutilized spectrum. Regulatory committees in many countries are taking into account the spectrum policy of dynamic spectrum access using this technology. The TV band is under consideration as a first step
Multiple People Tracking Based on Temporal Color Feature (2003)

We present a method for detecting and tracking multiple people totally occluded or out of sight in a scene for some period of time in image sequences. Our approach is to use time weighted color information (i.e. the temporal color) for robust medium-term people tracking. The temporal color is the set of pairs of a color value and its associated weights. The weight is related to the size, duration and frequency of appearance of the color region, as well as the number of people adjacent to the target person. It assures our system to continuously track people moving in a group with occlusion. Most systems have built an appearance model for each person to solve occlusion problems. The appearance model contains certain information on the target person — color, shape, texture, position, velocity and face pattern. We use temporal color in the appearance model for the identification of the people occluded or out of sight in the scene upon their reappearance. Experimental results show that the temporal color is more stable than shape or intensity in various cases.
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells (2005)

To determine mechanistically how siRNAs mediate transcriptional gene silencing (TGS) in human cells, we have measured histone methylation at targeted promoters, the dependency on active transcription, and whether or not both strands of the siRNA are required for siRNA-mediated TGS. We report here that siRNA treatment increases both H3K9 and H3K27 methylation of the targeted EF1A promoter and that this increase is dependent on nuclear specific delivery of the siRNA. We also find that TGS can be directed by the antisense strand alone, and requires active transcription by RNA polymerase II in human cells as evidenced by sensitivity to alpha-amanatin. The observation of antisense strand-specific siRNA-mediated TGS of EF1A was substantiated by targeting the U3 region of the HIV-1 LTR/promoter. Furthermore, we show that the antisense strand of siRNA EF52 associates with the transiently expressed Flag-tagged DNMT3A, the targeted EF1A promoter, and trimethylated H3K27. The observations reported here implicate a functional link between siRNA-mediated targeting of genomic regions (promoters), RNA Pol II function, histone methylation, and DNMT3A and support a paradigm in which the antisense strands of siRNAs alone can direct sequence-specific transcriptional gene silencing in human cells.
A Game Theoretic Approach for the Ride-Sourcing Territory Sharing Problem (2015)

This paper provides a description to a class of cooperatives bargaining games for the ride-souring applications. We first describe the ride-sourcing problem, then we provide a solution formulation for this problem. Finally, a bargaining based solution model is presented.
Smart manufacturing of low-cost integrated panel by resin-transfer molding (2004)

We proposed a smart manufacturing system for resin transfer molding (RTM). Numerical simulation was used to predict the resin-flow behavior and determined the preliminary process conditions. The injection pressure was controlled with a dielectric sensor, which monitored the resinflow front. This approach was experimentally demonstrated by fabricating an access door panel model of a fuselage structure.
Full Scale Crash Test on a Group of Piles in Clay (2015)

This paper presents a full scale test on a pile group as part of a study on the lateral behavior of groups of piles subjected to impact loads. In recent years, pile groups have been installed as an efficient system to protect structures such as bridge piers, offshore platforms and significant buildings against extreme horizontal loads from ships or vehicles. There has been a crucial need to design such impact resisting structures embedded in soils. One of the most effective tools to understand the soil behavior during impacts is a full scale crash test. These tests are rare as they are expensive and difficult to run. This paper presents part of a comprehensive study on a group of four piles embedded 2 m in hard clay, connected together with two beams, and designed to arrest a 2,300 kg pickup truck with an approaching velocity of 100 km/h. In order to monitor the behavior of the piles and beams, the instrumentation included accelerometers on the truck, strain gages on the piles and high speed cameras for displacement. Such full scale tests can provide valuable data for calibration of analytical or numerical models. The details of the full scale test along with the measured response are presented.