gebhart/patrepeval huggingface dataset:
Measurement of the CP-violating phase ϕ from Bs0→J/ψπ+π− decays in 13 TeV pp collisions (2019)

Decays of B and B‾ mesons into J/ψππ final states are studied in a data sample corresponding to 1.9 fb of integrated luminosity collected with the LHCb detector in 13 TeV pp collisions. A time-dependent amplitude analysis is used to determine the final-state resonance contributions, the CP-violating phase ϕ=−0.057±0.060±0.011 rad, the decay-width difference between the heavier mass B eigenstate and the B meson of −0.050±0.004±0.004 ps, and the CP-violating parameter |λ|=1.01 ±0.03, where the first uncertainty is statistical and the second systematic. These results are combined with previous LHCb measurements in the same decay channel using 7 TeV and 8 TeV pp collisions obtaining ϕ=0.002±0.044±0.012 rad, and |λ|=0.949±0.036±0.019.
A New Natural Defense Against Airborne Pathogens (2020)

We propose the nasal administration of calcium-enriched physiological salts as a new hygienic intervention with possible therapeutic application as a response to the rapid and tenacious spread of COVID-19. We test the effectiveness of these salts against viral and bacterial pathogens in animals and humans. We find that aerosol administration of these salts to the airways diminishes the exhalation of the small particles that face masks fail to filter and, in the case of an influenza swine model, completely block airborne transmission of disease. In a study of 10 human volunteers (5 less than 65 years and 5 older than 65 years), we show that delivery of a nasal saline comprising calcium and sodium salts quickly (within 15 min) and durably (up to at least 6 h) diminishes exhaled particles from the human airways. Being predominantly smaller than 1 μm, these particles are below the size effectively filtered by conventional masks. The suppression of exhaled droplets by the nasal delivery of calcium-rich saline with aerosol droplet size of around 10 μm suggests the upper airways as a primary source of bioaerosol generation. The suppression effect is especially pronounced (99%) among those who exhale large numbers of particles. In our study, we found this high-particle exhalation group to correlate with advanced age. We argue for a new hygienic practice of nasal cleansing by a calcium-rich saline aerosol, to complement the washing of hands with ordinary soap, use of a face mask, and social distancing.
Nerve Fiber Layer Assessment with a Retinal Laser Ellipsometer (1991)

Retinal ganglion cell axons form the innermost layer of the retina known as the nerve fiber layer. These axons converge to form the optic nerve, which transmits the visual image from the eye to the brain. In glaucoma, there is damage to these nerve fibers as they leave the eye through the lamina cribrosa, a fenestrated network of connective tissue. In the retina, the nerve fibers spread out in a thin layer creating a characteristic fingerprint. It is likely that loss of even a few axons can alter the fingerprint and be observed in the retinal nerve fiber layer when appropriate techniques are used.
Toward Hard X-ray Transmission Microscopy at the ANATOMIX Beamline of Synchrotron SOLEIL (2018)

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Frequency synthesis for 60-GHz OFDM transceivers (2008)

We present an integer-N PLL architecture for 60 GHz OFDM systems compatible with the IEEE 802.15.3c channel plan. Based on a sliding-IF architecture using a 48 GHz voltage-controlled oscillator (VCO) and a 19.2 MHz crystal reference, we predict an rms phase error below three degree after correction of the common phase error. This will enable a silicon-based low-cost millimetre-wave transceiver for Gbps OFDM transmission. Requirements for the crystal noise floor and the VCO phase noise are also formulated.
Supplemental Experimental Procedures from Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes (2023)

&lt;p&gt;Supplementary Methods.&lt;/p&gt;
How Computational Modeling can Help to Predict Gas Transfer in Artificial Lungs Early in the Design Process (2019)

Wearable extracorporeal membrane oxygenation (ECMO) circuits may soon become a viable alternative to conventional ECMO treatment. Common device-induced complications, however, such as blood trauma and oxygenator thrombosis, must first be addressed to improve long-term reliability, since ambulatory patients cannot be monitored as closely as intensive care patients. Additionally, an efficient use of the membrane surface can reduce the size of the devices, priming volume, and weight to achieve portability. Both challenges are linked to the hemodynamics in the fiber bundle. While experimental test methods can often only provide global and time-averaged information, computational fluid dynamics (CFD) can give insight into local flow dynamics and gas transfer before building the first laboratory prototype. In this study, we applied our previously introduced micro-scale CFD model to the full fiber bundle of a small oxygenator for gas transfer prediction. Three randomized geometries as well as a staggered and in-line configuration were modeled and simulated with Ansys CFX. Three small laboratory oxygenator prototypes were built by stacking fiber segments unidirectionally with spacers between consecutive segments. The devices were tested in vitro for gas transfer with porcine blood in accordance with ISO 7199. The error of the predicted averaged CFD oxygen saturations of the random 1, 2, and 3 configurations relative to the averaged in-vitro data (over all samples and devices) was 2.4%, 4.6%, 3.1%, and 3.0% for blood flow rates of 100, 200, 300, and 400 ml/min, respectively. While our micro-scale CFD model was successfully applied to a small oxygenator with unidirectional fibers, the application to clinically relevant oxygenators will remain challenging due to the complex flow distribution in the fiber bundle and high computational costs. However, we will outline our future research priorities and discuss how an extended mass transfer correlation model implemented into CFD might enable an a priori prediction of gas transfer in full size oxygenators.
The STOne Transform: Multi-Resolution Image Enhancement and Compressive Video (2015)

Compressive sensing enables the reconstruction of high-resolution signals from under-sampled data. While the compressive methods simplify data acquisition, they require the solution of difficult recovery problems to make use of the resulting measurements. This paper presents a new sensing framework that combines the advantages of both the conventional and the compressive sensing. Using the proposed sum-to-one transform, the measurements can be reconstructed instantly at the Nyquist rates at any power-of-two resolution. The same data can then be enhanced to higher resolutions using the compressive methods that leverage sparsity to beat the Nyquist limit. The availability of a fast direct reconstruction enables the compressive measurements to be processed on small embedded devices. We demonstrate this by constructing a real-time compressive video camera.
Mature focal adhesions require coalescence with vimentin and develop in a cell-passage dependent manner. (2015)

&lt;p&gt;(A) RbCF2 and RbCF8 cells were cultured as in &lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133399#pone.0133399.g001" target="_blank"&gt;Fig 1&lt;/a&gt;, plated for 30 min followed by treatment in presence or absence of WFA (1 μM) for 1 h. Cells were fixed and stained with paxillin (green), vimentin (red), and DAPI (blue). Scale bar = 35 μm. (B) Peripheral FA mean areas from RbCF2 (black columns) and RbCF8 (grey columns) cells were measured and represented in arbitrary units. (*P &lt;0.0001; **P &lt;0.0001).&lt;/p&gt;
Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene (1999)

Uteroglobin (UG) is a multifunctional, secreted protein that has receptor-mediated functions. The human UG (hUG) gene is mapped to chromosome 11q12.2-13.1, a region frequently rearranged or deleted in many cancers. Although high levels of hUG expression are characteristic of the mucosal epithelia of many organs, hUG expression is either drastically reduced or totally absent in adenocarcinomas and in viral-transformed epithelial cells derived from the same organs. In agreement with these findings, in an ongoing study to evaluate the effects of aging on UG-knockout mice, 16/16 animals developed malignant tumors, whereas the wild-type littermates (n = 25) remained apparently healthy even after 11/2 years. In the present investigation, we sought to determine the effects of induced-expression of hUG in human cancer cells by transfecting several cell lines derived from adenocarcinomas of various organs with an hUG-cDNA construct. We demonstrate that induced hUG expression reverses at least two of the most important characteristics of the transformed phenotype (i.e., anchorage-independent growth on soft agar and extracellular matrix invasion) of only those cancer cells that also express the hUG receptor. Similarly, treatment of the nontransfected, receptor-positive adenocarcinoma cells with purified recombinant hUG yielded identical results. Taken together, these data define receptor-mediated, autocrine and paracrine pathways through which hUG reverses the transformed phenotype of cancer cells and consequently, may have tumor suppressor-like effects.
5G Radio Access Network Design - A Brief Overview On The 5G-Ppp Project Metis-Ii (2015)

<em>Abstract</em>—The METIS-II project will be an EU-funded project within the 5G Infrastructure Public Private Partnership (5G-PPP) that is dedicated towards an overall 5G radio access network (RAN) design. It will build strongly upon the METIS project, which has laid the foundation for 5G by identifying key scenarios and requirements and determining the most promising technology components and key system design characteristics. However, METIS-II will go significantly further than previous projects by developing a comprehensive and detailed 5G RAN design according to “technology readiness level 2”. This is seen as an especially important step to ensure a timely and efficient standardization of 5G, likely to start in 2016. To achieve this, in addition to the technical work on designing the comprehensive control and user plane of an overall 5G RAN, the METIS-II project has the ambition to actively foster the collaboration within 5G-PPP, for instance by conducting workshops in particular with other projects within the wireless strand, and obtain an early pre-standardization consensus on fundamental design aspects related to the 5G RAN. In this paper, a brief overview on the project is provided, covering the objectives, the consortium composition, project structure and key innovations, as well as the timing and expected impact of the project.
Abstract 291: The Type I Interferon Receptor Amplifies Innate Immune Responses After Myocardial Infarction (2018)

Ischemic heart disease (IHD), the leading cause of death in the world, begins with myocardial infarction (MI). Overly exuberant innate immune responses are detrimental to post-MI healing and repair. Efforts to achieve post-MI cardioprotection focused on blocking NFκB-mediated inflammation have been largely unsuccessful. We recently discovered that MI leads to cytosolic DNA sensing in leukocytes and triggers the interferon regulatory factor 3 (IRF3)-dependent expression of interferon stimulated genes (ISGs). We found that genetic inhibition of IRF3 after MI reduces inflammation, limits ventricular dilation and contractile dysfunction, and improves survival. In this work, we test two hypotheses. 1) Type I interferons (IFNs), secreted by a few DNA-sensing/IRF3-activated leukocytes, signal via type I interferon alpha/beta receptors (IFNARs), to amplify ISG expression after MI. 2) Pharmacologic inhibition of type I IFN/IFNAR signaling blocks response amplification and significantly reduces ISG expression. We established DNA-stimulated bone marrow derived macrophages (BMDMs) as an in vitro model of the post-MI type I IFN response and measured the expression of ISGs ( Cxcl10 , Irf7 , Ifit1 , and Ifit3 ) by qPCR. We quantified and compared changes in ISG expression caused by direct DNA stimulation, incubation with conditioned media containing secreted factors from DNA-stimulated cells, and treatment with an IFNAR neutralizing antibody. Compared to unstimulated BMDMs, ISG expression was amplified by &gt;35-fold in BMDMs stimulated by either DNA or conditioned media. However, there was no significant amplification when the experiments were performed in the presence of an IFNAR neutralizing antibody. In a mouse model of MI, single cell RNA-Seq revealed that IFNAR-deficient mice have reduced numbers of ISG-expressing leukocytes compared to wild type controls, which indicates that IFNAR-dependent amplification of innate immune responses occurs after MI in vivo . Collectively, these results demonstrate that IFNAR ligands are important amplifiers of DNA-induced innate immune responses after MI and suggest that anti-interferon therapy should be further investigated in vivo to improve clinical outcomes after MI.
Separation Of Pulsar Signals In FSR System (2018)

In this paper, one possible algorithm for target detection and velocity estimation in a pulsar FSR system is proposed. In this processing algorithm, two approaches for extraction of the target signal from the input mixture “direct pulsar signal + reradiated target signal” are studied and compared. The signal processing algorithm is evaluated by computer simulation.
Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection (2020)

The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.
Myogenic Cell Transplantation in Genetic and Acquired Diseases of Skeletal Muscle (2021)

This article will review myogenic cell transplantation for congenital and acquired diseases of skeletal muscle. There are already a number of excellent reviews on this topic, but they are mostly focused on a specific disease, muscular dystrophies and in particular Duchenne Muscular Dystrophy. There are also recent reviews on cell transplantation for inflammatory myopathies, volumetric muscle loss (VML) (this usually with biomaterials), sarcopenia and sphincter incontinence, mainly urinary but also fecal. We believe it would be useful at this stage, to compare the same strategy as adopted in all these different diseases, in order to outline similarities and differences in cell source, pre-clinical models, administration route, and outcome measures. This in turn may help to understand which common or disease-specific problems have so far limited clinical success of cell transplantation in this area, especially when compared to other fields, such as epithelial cell transplantation. We also hope that this may be useful to people outside the field to get a comprehensive view in a single review. As for any cell transplantation procedure, the choice between autologous and heterologous cells is dictated by a number of criteria, such as cell availability, possibility of <i>in vitro</i> expansion to reach the number required, need for genetic correction for many but not necessarily all muscular dystrophies, and immune reaction, mainly to a heterologous, even if HLA-matched cells and, to a minor extent, to the therapeutic gene product, a possible antigen for the patient. Finally, induced pluripotent stem cell derivatives, that have entered clinical experimentation for other diseases, may in the future offer a bank of immune-privileged cells, available for all patients and after a genetic correction for muscular dystrophies and other myopathies.
Subnets of scale-free networks are not scale-free: Sampling properties of networks (2005)

Most studies of networks have only looked at small subsets of the true network. Here, we discuss the sampling properties of a network's degree distribution under the most parsimonious sampling scheme. Only if the degree distributions of the network and randomly sampled subnets belong to the same family of probability distributions is it possible to extrapolate from subnet data to properties of the global network. We show that this condition is indeed satisfied for some important classes of networks, notably classical random graphs and exponential random graphs. For scale-free degree distributions, however, this is not the case. Thus, inferences about the scale-free nature of a network may have to be treated with some caution. The work presented here has important implications for the analysis of molecular networks as well as for graph theory and the theory of networks in general.
Erwiderung – Antwort auf den Leserbrief von Herrn Professor Kerner (2013)

Ziel unserer Publikation [1] war die Konkretisierung der Anforderungen an die Messqualität und die Qualitätssicherung von POCT-Glukose-Messsystemen für die primäre GDM-Diagnostik, um den betroffenen Herstellern sowie den für die Zulassung und die Überwachung verantwortlichen Funktionsträgern eine möglichst aktuelle Empfehlung durch die zwei mit dieser Fragestellung befassten Fachgesellschaften in Deutschland zur Verfügung zu stellen. Einleitend dazu werden im Abschnitt „Grundlagen und Voraussetzungen“ die dafür relevante S3-Leitlinie der DDG und der DGGG [2] und die darauf basierenden Praxisempfehlungen[3] zitiert, die die angesprochenen „Hinweise zur Verwendung von POCT-Glukose-Messsystemen zur Diagnostik des Gestationsdiabetes“ und das „beachtenswerte Ergebnis, dass dies prinzipiell möglich ist“ enthalten. Prof. Kerners Ablehnung dieser Möglichkeit wurde schon 2012 in Diabetologie und Stoffwechsel publiziert [4] und von Dr. Kleinwechter, dem Sprecher der GDM-Leitliniengruppe, ausführlich beantwortet [5].
Efficient simple structure red phosphorescent organic light emitting devices with narrow band-gap fluorescent host (2008)

Using a narrow band-gap fluorescent host material, bis(10-hydroxybenzo[h] quinolinato)beryllium complex, efficient red phosphorescent organic light emitting diodes (PHOLEDs) comprising two layers have been reported. Significantly low driving voltage of 4.5V to reach a luminance of 1000cd∕m2 is reported in this simple structure PHOLEDs. The current and power efficiencies of bilayered red PHOLED are 9.66cd∕A and 6.90lm∕W, respectively, promising for low power display and lighting applications.
Effect of Light Intensity on Ultraviolet Irradiated Polypropylene and its Compatibilization with CaCO3 (2009)

Some oxygen-containing groups such as C—O and C=O were introduced onto the molecular chains of polypropylene (PP) by ultraviolet irradiation at different light intensities in air. The rate of introducing oxygen-containing groups was increased with increasing light intensity. After irradiating at different light intensities, there was no gel formation in PP. The crystal shape of irradiated PP at different light intensities kept unchanged, which was still monoclinic crystal, but its melting temperature decreased and the crystallinity increased, and meanwhile their variation extent was increased with increasing light intensity. The melt flow rate and hydrophilicity of irradiated PP at higher light intensity were higher than those of PP irradiated at lower light intensity. A little of irradiated PP at different light intensities was added into PP/CaCO 3 composite and the PP/CaCO 3 composite compatibilized by the irradiated PP was obtained. Compared with those of PP/CaCO 3 composite, the dispersion, interfacial interaction, and mechanical properties of the compatibilized PP/CaCO 3 composite were improved. The mechanical properties of PP/CaCO 3 composite added with PP irradiated for 40 min at lower light intensity and PP irradiated for 30 min at higher light intensity reached a maximum value.
Enhanced Performance of Zirconium‐Doped Ceria Catalysts for the Methoxycarbonylation of Anilines (2020)

The methoxycarbonylation of anilines stands as an attractive method for the phosgene-free production of carbamates. Despite the high yields obtained for ceria catalysts, the reduction of the amount of side products and the prevention of catalyst deactivation still represent major hurdles in this chemistry. One advantage of ceria is the possibility of tuning its reactivity by doping its lattice with other metals. In the present work, a series of doped ceria-based materials, prepared by substitution with metals, are evaluated in the methoxycarbonylation of 2,4-diaminotoluene with dimethyl carbonate. Among all catalysts, containing Eu, Hf, La, Pr, Sm, Tb, Y or Zr, ceria promoted with 2 mol % Zr exhibited 96 % selectivity towards the desired carbamates, improving the pure CeO<sub>2</sub> catalyst. Density functional theory demonstrates that two descriptors are needed: 1) a geometric factor that governs the reduction of energy barriers for carbamate formation through ureas; 2) catalyst basicity as N-H bonds need to be activated. Assessment in subsequent reaction cycles revealed that the CeO<sub>2</sub> -ZrO<sub>2</sub> catalyst is more stable than bulk CeO<sub>2</sub> , along with the reduction of fouling processes.
Supplementary Figure 2 from Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity (2023)

Supplementary Figure 2 from Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity
Role of Confinement on Carrier Transport in Ge–SixGe1–x Core–Shell Nanowires (2011)

We examine the impact of shell content and the associated hole confinement on carrier transport in Ge-Si(x)Ge(1-x) core-shell nanowires (NWs). Using NWs with different Si(x)Ge(1-x) shell compositions (x = 0.5 and 0.7), we fabricate NW field-effect transistors (FETs) with highly doped source/drain and examine their characteristics dependence on shell content. The results demonstrate a 2-fold higher mobility at room temperature, and a 3-fold higher mobility at 77K in the NW FETs with higher (x = 0.7) Si shell content by comparison to those with lower (x = 0.5) Si shell content. Moreover, the carrier mobility shows a stronger temperature dependence in Ge-Si(x)Ge(1-x) core-shell NWs with high Si content, indicating a reduced charge impurity scattering. The results establish that carrier confinement plays a key role in realizing high mobility core-shell NW FETs.