gebhart/patrepeval huggingface dataset:
Open-Set Patient Activity Recognition With Radar Sensors and Deep Learning (2023)

Open-set recognition (OSR) has achieved significant importance in recent years. For a robust recognition system, we need to identify the right class from a myriad of knowns and unknowns. In this work, we build and compare OSR systems for patient activity recognition (PAR) using compact radar sensors in a hospital setting. Radar sensors are an important part of a privacy-preserving monitoring system. Specifically, the proposed approach is based on a deep discriminative representation network (DDRN) trained using the large margin cosine loss (LMCL) and triplet loss (TL). A probability of an inclusion model in the embedding space based on the Weibull distribution is able to separate knowns from unknowns. This overall approach limits the risk of open space and enables us to easily identify any unknown activities. Our experiments show that the proposed approach is significantly better for open-set human activity recognition (HAR) with radar when compared with the state-of-the-art open-set approaches.
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs (2017)

More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would induce efficient bone regeneration and fracture repair. To test this hypothesis, we surgically created a critical-sized bone fracture in the tibiae of Yucatán mini-pigs, a clinically relevant large animal model. A collagen scaffold was implanted in the fracture to facilitate recruitment of endogenous mesenchymal stem/progenitor cells (MSCs) into the fracture site. Two weeks later, transcutaneous ultrasound-mediated reporter gene delivery successfully transfected 40% of cells at the fracture site, and flow cytometry showed that 80% of the transfected cells expressed MSC markers. Human <i>bone morphogenetic protein-6</i> (<i>BMP</i>-<i>6</i>) plasmid DNA was delivered using ultrasound in the same animal model, leading to transient expression and secretion of BMP-6 localized to the fracture area. Micro-computed tomography and biomechanical analyses showed that ultrasound-mediated <i>BMP-6</i> gene delivery led to complete radiographic and functional fracture healing in all animals 6 weeks after treatment, whereas nonunion was evident in control animals. Collectively, these findings demonstrate that ultrasound-mediated gene delivery to endogenous mesenchymal progenitor cells can effectively treat nonhealing bone fractures in large animals, thereby addressing a major orthopedic unmet need and offering new possibilities for clinical translation.
Proximity to human settlement is directly related to carriage of critically important antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae in Silver Gulls (2021)

Abstract Human population and activities play an important role in dissemination of antimicrobial resistant bacteria. This study investigated the relationship between carriage rates of critically important antimicrobial-resistant (CIA-R) Escherichia coli and Klebsiella pneumoniae by Silver Gulls and their proximity to human populations. Faecal swabs (n=229) were collected from Silver Gulls across 10 southern coastline locations in Western Australia (WA). The sampling locations included main town centres and remote areas. Fluoroquinolone and extended-spectrum cephalosporin-resistant E. coli and K. pneumoniae were isolated and tested for antimicrobial sensitivity. Genome sequencing was performed to validate phenotypic resistance profiles and determine the molecular characteristics of strains. CIA-R E. coli and K. pneumoniae were detected in 69 (30.1%) and 20 (8.73%) of the faecal swabs respectively. Two large urban locations tested positive for CIA-R E. coli (frequency ranging from 34.3%-84.3%), and/or for CIA-R K. pneumoniae (frequency ranging from 12.5%-50.0%). A small number of CIA-R E. coli (3/31, 9.7%) were identified at a small tourist town, but no CIA-R bacteria were recovered from gulls at remote sites. Commonly detected E. coli sequence types (STs) included ST131 (12.5%) and ST1193 (10.0%), and five K. pneumoniae STs were found. Resistance genes including bla CTX-M-3 , bla CTX-M-15 and bla CTX-M-27 were identified in both bacterial species. High-level colonisation of CIA-R E. coli and K. pneumoniae in Silver Gulls in and around urban areas compared to remote locations substantiates that anthropogenic activities are strongly associated with acquisition of resistant bacteria by gulls. Importance Humans play an important role in dissemination of antimicrobial resistant bacteria. This study investigated the relationship between carriage rates of resistant bacterial pathogens (Escherichia coli and Klebsiella pneumoniae ) among Silver Gulls and their proximity to human populations. The frequency of resistant E. coli carriage was high (ranging from 34.3 – 84.3%) in the samples collected from areas with high human population density while resistant K. pneumoniae frequencies at these sites varied from 0 to 50%. However, resistant E. coli and K. pneumoniae were not recovered from any of the remote sites that did not have a permanent human population. This study, conducted across a large stretch of the southwestern Australian coastline, indicated that seagulls act as vectors in carrying and disseminating antimicrobial resistant bacteria, including clinically significant strains. High-level colonisation of resistant E. coli and K. pneumoniae in Silver Gulls in and around urban areas compared to remote locations substantiates that human activities are strongly associated with acquisition of resistant bacteria by Silver gulls.
Table S1 from Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene (2023)

&lt;p&gt;Abs IC50 values (µM) for 36 small molecule inhibitors across a panel of cancer cell lines.&lt;/p&gt;
The 2014 ACM international conference on Measurement and modeling of computer systems (2014)

It is our pleasure to welcome you to SIGMETRICS 2014. SIGMETRICS is the flagship conference of the ACM special interest group for the computer systems performance evaluation community.

This year's conference continues the long-standing SIGMETRICS tradition to publish the highestquality research on the development and application of state-of-the-art, broadly applicable analytic, simulation, and measurement-based performance evaluation techniques. We are pleased to present a diverse set of papers in areas such as sensor, mobile and wireless networks, queuing and scheduling, msocial networks, memory technologies, large-scale measurement studies, system tracing and monitoring, data center resource provisioning and energy management. Our authors hail from 13 countries on 4 continents and represent both academia and industry.

SIGMETRICS 2014 received 237 submissions, the second highest number since the founding of this SIG. Of these, we accepted 40 papers, the largest in the history of the conference, while still maintaining a highly competitive acceptance rate of 16.8%. During the review process, the Program Committee provided 4-6 reviews for each paper and made extensive use of HotCRP's Comment feature for online discussions. The Program Committee then met in person in a 1.5-day meeting on February 7-8, 2014, in Toronto, Canada, and selected 40 papers to be included as full papers in the technical program. In addition, 31 papers were invited as 2-page posters, and the authors of 30 of these papers accepted our invitation. As an experiment, we invited for the first time also all authors of full papers to present a poster version of their paper during one of the breaks at the conference to foster interaction between authors and attendees. We used Eddie Kohler's excellent HotCRP software to manage all stages of the review process, from submission to author notification.
Development of Control for a Serpentine Robot (2007)

This paper describes the development and testing of control of the OmniTread OT-4 robot by the seventh generation (7G) control system. Control of OT-4 was developed in the Yobotics 3D simulator by an iterative process combining genetic algorithm, learning and analytic programming techniques. The control system developed in simulation was tested by controlling the real OT-4 robot in the laboratory. The performance of the real OT-4 robot under 7G control on stairs, parallel bars, a slalom course, and stairs with obstacles corresponded well to the simulated performance on which development of the control system was based.
<title>Experimental measurements of RXI concentrators</title> (1995)

A small series of nonimaging RXI concentrators designed for concentrating radiation on a 1 mm<SUP>2</SUP> photodiode have been manufactured by injection molding of PMMA (polymethyl methacrylate). Their entry aperture diameter is 40 mm and the design acceptance angle is +/- 2.24 degrees. Measurements done at (lambda) equals 890 nm show an optical efficiency of 33.8% and the relative transmission drops from 90% to 10% when the incidence angle varies from 1.2 to 3.4 degrees. A computer model of the concentrator which takes into account the different optical losses shows that optical efficiency is increased up to 57.1 % using silver metallization and (lambda) equals 800 nm. Moreover if photodiode position error is corrected, then the efficiency grows up to 76.2%, and if profile errors are also corrected, then the efficiency reach 88.2%. A more stepped angular transmission requires a most accurate manufacture process.
The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures (2020)

PA was inversely related to incident diabetes in the entire cohort across the study, with cross-sectional accelerometry results supporting these findings. This highlights the importance of PA within lifestyle intervention efforts designed to prevent diabetes and urges health care providers to consider both PA and weight when counseling high-risk patients.
On the Spectral and Energy Efficiencies of Full-Duplex Cell-Free Massive MIMO (2020)

In-band full-duplex (FD) operation is practically more suited for short-range communications such as WiFi and small-cell networks, due to its current practical limitations on the self-interference cancellation. In addition, cell-free massive multiple-input multiple-output (CF-mMIMO) is a new and scalable version of MIMO networks, which is designed to bring service antennas closer to end user equipments (UEs). To achieve higher spectral and energy efficiencies (SE-EE) of a wireless network, it is of practical interest to incorporate FD capability into CF-mMIMO systems to utilize their combined benefits. We formulate a novel and comprehensive optimization problem for the maximization of SE and EE in which power control, access point-UE (AP-UE) association and AP selection are jointly optimized under a realistic power consumption model, resulting in a difficult class of mixed-integer nonconvex programming. To tackle the binary nature of the formulated problem, we propose an efficient approach by exploiting a strong coupling between binary and continuous variables, leading to a more tractable problem. In this regard, two low-complexity transmission designs based on zero-forcing (ZF) are proposed. Combining tools from inner approximation framework and Dinkelbach method, we develop simple iterative algorithms with polynomial computational complexity in each iteration and strong theoretical performance guaranteed. Furthermore, towards a robust design for FD CF-mMIMO, a novel heap-based pilot assignment algorithm is proposed to mitigate effects of pilot contamination. Numerical results show that our proposed designs with realistic parameters significantly outperform the well-known approaches (i.e., small-cell and collocated mMIMO) in terms of the SE and EE. Notably, the proposed ZF designs require much less execution time than the simple maximum ratio transmission/combining.
Novel Potent Metallocenes against Liver Stage Malaria (2011)

Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo. Both transmission-blocking and blood-schizontocidal activities of the parent drug were conserved only in primacenes bearing a basic aliphatic amine group. Liver stage activity did not require this structural feature, and all metallocenes tested were comparable to or better than primaquine in this regard. Remarkably, the replacement of primaquine's aliphatic chain by hexylferrocene, as in compound 7, led to a ~45-fold-higher level activity against liver stage parasitemia than that of primaquine.
ChemInform Abstract: 1,2,4‐Triazolo(4,3‐a)pyrazine Derivatives with Human Renin Inhibitory Activity. Part 1. Synthesis and Biological Properties of Alkyl Alcohol and Statine Derivatives. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors (2020)

The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the success of HAART, new drugs with novel mechanisms are needed to combat viral resistance, improve adherence, and mitigate toxicities. Active site inhibitors of HIV-1 integrase are clinically validated for the treatment of HIV-1 infection. Here we describe allosteric inhibitors of HIV-1 integrase that bind to the LEDGF/p75 interaction site and disrupt the structure of the integrase multimer that is required for the HIV-1 maturation. A series of pyrazolopyrimidine-based inhibitors was developed with a vector in the 2-position that was optimized by structure-guided compound design. This resulted in the discovery of pyrazolopyrimidine <b>3</b>, which was optimized at the 2- and 7-positions to afford <b>26</b> and <b>29</b> as potent allosteric inhibitors of HIV-1 integrase that exhibited low nanomolar antiviral potency in cell culture and encouraging PK properties.
Population-Based Study of Severe Hypoglycemia Requiring Emergency Medical Service Assistance Reveals Unique Findings (2012)

The population burden of EMS requiring hypoglycemia is high in both DM and non-DM patients, and imposes significant burden on medical resources. It is associated with long-term mortality.
Morphological analysis and decomposition for Arabic speech-to-text systems (2009)

Language modelling for a morphologically complex language such as Arabic is a challenging task. Its agglutinative structure results in data sparsity problems and high out-of-vocabulary rates. In this work these problems are tackled by applying the MADA tools to the Arabic text. In addition to morphological decomposition, MADA performs context-dependent stem-normalisation. Thus, if word-level system combination, or scoring, is required this normalisation must be reversed. To address this, a novel context-sensitive method for morpheme-to-word conversion is introduced. The performance of the MADA decomposed system was evaluated on an Arabic broadcast transcription task. The MADA-based system out-performed the word-based system, with both the morphological decomposition and stem normalisation being found to be important.
Carbon‐Coated Porous Hollow Silicon Microspheres for High‐Capacity and Durable Lithium Storage (2023)

Abstract Silicon‐based materials are promising lithium‐ion battery (LIB) anodes owing to their natural abundance and high capacity. However, their practical application is restricted by the poor electrical conductivity and large volume expansion. Herein, we successfully construct carbon coated porous hollow silicon microspheres (Si‐40@C) as LIB anode materials, which are derived from the acid etching of commercial AlSi alloy with subsequent chemical vapor deposition carbon coating. The porous hollow structure of Si‐40@C buffers the volume variation and promotes the transportation of Li + ; the carbon coating enhances the overall conductivity as well as structural stability. The as‐prepared Si‐40@C porous hollow microspheres deliver a high reversible capacity (2029 mAh g −1 at 0.2 A g −1 ), good cyclability (1668 mAh g −1 after 100 cycles at 0.2 A g −1 ), and an ideal rate capability (1200 mAh g −1 at 10 A g −1 ).
Supplementary Data from Intertumoral Heterogeneity of CD3<sup>+</sup> and CD8<sup>+</sup> T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis (2023)

&lt;p&gt;Suppl Figure Legend&lt;/p&gt;
Extensive experimental mapping of sonoluminescence parameter space (2000)

Experimental phase diagrams are compared to theoretical predictions based on the Dissociation Hypothesis (DH) theory of single bubble sonoluminescence (SBSL). Ambient radius (R(o))- acoustic drive pressure (P(a)) phase diagrams are presented for krypton-nitrogen mixtures and for a collection of data with other noble gas-nitrogen mixtures. The data is also presented in terms of expansion ratio (maximum bubble radius R(max)/R(o)) vs P(a) and relative light intensity vs P(a). The results provide further evidence of the validity of DH and also provide a thorough mapping of SBSL at a single frequency.
InAs/GaAs quantum dot laterally coupled distributed feedback lasers at 1.3 μm (2022)

We report the InAs/GaAs quantum dot laterally coupled distributed feedback (LC-DFB) lasers operating at room temperature in the wavelength range of 1.31 m. First-order chromium Bragg gratings were fabricated alongside the ridge waveguide to obtain the maximum coupling coefficient with the optical field. Stable continuous-wave single-frequency operation has been achieved with output power above 5 mW/facet and side mode suppression ratio exceeding 52 dB. Moreover, a single chip integrating three LC-DFB lasers was tentatively explored. The three LC-DFB lasers on the chip can operate in single mode at room temperature, covering the wavelength span of 35.6 nm.
Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted 18F-DCFPyL in peripheral ganglia (2017)

As PSMA-targeted agents become more widely disseminated, the patterns of uptake in structures that are not directly relevant to patients' cancers must be understood. This is the first systematic evaluation of the uptake of <sup>18</sup>F-DCFPyL in ganglia demonstrating a general trend with a descending frequency of radiotracer accumulation in lumbar, cervical, stellate, celiac, and sacral ganglia. The underlying biology that leads to variability of PSMA-targeted radiotracers in peripheral ganglia is not currently understood, but may provide opportunities for future research.
Achieving Customer Satisfaction Through Robust Design (1994)

A winning product has to consistently outperform its rivals by providing value in today's highly competitive markets. At the heart of consistent value is robust design — the process of ensuring that a product will perform well despite variations in raw materials, components, manufacturing, and operating conditions. It consists of steps for identifying key parameters that affect the customer, analyzing to predict and improve robustness, and measuring to confirm performance. As it exists in AT&Ts Transmission Systems Business Unit (TSBU) for hardware development, robust design is a real, effective process. It should be used to ensure design robustness for all designs, especially those intended for multi-use platforms.
Real-time learning of accurate patch rectification (2009)

Recent work showed that learning-based patch rectification methods are both faster and more reliable than affine region methods. Unfortunately, their performance improvements are founded in a computationally expensive offline learning stage, which is not possible for applications such as SLAM. In this paper we propose an approach whose training stage is fast enough to be performed at run-time without the loss of accuracy or robustness. To this end, we developed a very fast method to compute the mean appearances of the feature points over sets of small variations that span the range of possible camera viewpoints. Then, by simply matching incoming feature points against these mean appearances, we get a coarse estimate of the viewpoint that is refined afterwards. Because there is no need to compute descriptors for the input image, the method is very fast at run-time. We demonstrate our approach on tracking-by-detection for SLAM, real-time object detection and pose estimation applications.
Axiomatic Social Choice Theory: An Overview and Interpretation (1976)

Normative concerns are central to the study of democratic theory and the policy- relevant areas of political science and economics. The same normative concerns are central to the study of axiomatic social choice theory. Despite similarities in origin and in underlying philosophical orientation, the fields have evolved separately and within different methodologies. This paper attempts to survey the most recent major results in axiomatic social choice theory within a unifying interpretation accessible to nonspecialists.
[Poster Session: 2012 IEEE Workshop on Microelectronics and Electron Devices (WMED)] (2012)

This Poster Session discusses the following: PMOS Device Performance Improvement using Buried Contact Implants; Deep Trench Patterning and Lift-off Resist in Micro-fluidic Devices; and Nano-ionic Conductive Bridge Memristors based on Chalcogenide Glasses: Electrical Performance Characterization and Modeling.
Personalized cancer vaccines: more is more? (2022)

We caught up with Geneos Therapeutics Founder Niranjan Sardesai to learn more about the company’s highly personalized cancer vaccines, which target up to 40 tumor neoantigens in a single DNA plasmid vaccine.Niranjan Sardesai is Founder, President, and CEO of Geneos Therapeutics. He is recognized as an expert in nucleic acid vaccines and immunotherapies and led the development of the DNA medicines technologies that are at the core of Geneos’ GT-EPIC™ platform. Previously he served as Chief Operating Officer and Head of R&amp;D at Inovio Pharmaceuticals. He was responsible for the development pipeline and led the capital-raising efforts for the company via strategic out-licensing of pipeline products to secure major licensing deals totaling over $1 Bn and securing over $150M in non-dilutive grants and contracts from funding agencies. Dr. Sardesai received a PhD in Chemistry from the California Institute of Technology and an MBA from the Wharton School of the University of Pennsylvania, where he was the recipient of the Shils-Zeidman Award in Entrepreneurship
Application-aware prioritization mechanisms for on-chip networks (2009)

Network-on-Chips (NoCs) are likely to become a critical shared resource in future many-core processors. The challenge is to develop policies and mechanisms that enable multiple applications to efficiently and fairly share the network, to improve system performance. Existing local packet scheduling policies in the routers fail to fully achieve this goal, because they treat every packet equally, regardless of which application issued the packet.