gebhart/patrepeval huggingface dataset:
Node Embedding with Adaptive Similarities for Scalable Learning over\n Graphs (2018)

Node embedding is the task of extracting informative and descriptive features\nover the nodes of a graph. The importance of node embeddings for graph\nanalytics, as well as learning tasks such as node classification, link\nprediction and community detection, has led to increased interest on the\nproblem leading to a number of recent advances. Much like PCA in the feature\ndomain, node embedding is an inherently \\emph{unsupervised} task; in lack of\nmetadata used for validation, practical methods may require standardization and\nlimiting the use of tunable hyperparameters. Finally, node embedding methods\nare faced with maintaining scalability in the face of large-scale real-world\ngraphs of ever-increasing sizes. In the present work, we propose an adaptive\nnode embedding framework that adjusts the embedding process to a given\nunderlying graph, in a fully unsupervised manner. To achieve this, we adopt the\nnotion of a tunable node similarity matrix that assigns weights on paths of\ndifferent length. The design of the multilength similarities ensures that the\nresulting embeddings also inherit interpretable spectral properties. The\nproposed model is carefully studied, interpreted, and numerically evaluated\nusing stochastic block models. Moreover, an algorithmic scheme is proposed for\ntraining the model parameters effieciently and in an unsupervised manner. We\nperform extensive node classification, link prediction, and clustering\nexperiments on many real world graphs from various domains, and compare with\nstate-of-the-art scalable and unsupervised node embedding alternatives. The\nproposed method enjoys superior performance in many cases, while also yielding\ninterpretable information on the underlying structure of the graph.\n
Oxidative Lipidomics of Apoptosis: Quantitative Assessment of Phospholipid Hydroperoxides in Cells and Tissues (2009)

Oxidized phospholipids play essential roles in execution of mitochondrial stage of apoptosis and clearance of apoptotic cells. The identification and quantification of oxidized phospholipids generated during apoptosis can be successfully achieved by oxidative lipidomics. With this approach, diverse molecular species of phospholipids and their hydroperoxides are identified and characterized by soft-ionization mass-spectrometry techniques such as electrospray ionization (ESI). Quantitative assessment of lipid hydroperoxides is performed by fluorescence HPLC-based protocol. The protocol is based on separation of phospholipids using two-dimensional-high-performance thin-layer chromatography (2-D-HPTLC). Phospholipids are hydrolyzed using phospholipase A(2). The fatty acid hydroperoxides (FA-OOH) released is quantified by a fluorometric assay using Amplex red reagent and microperoxidase-11 (MP-11). Detection limit of this protocol is 1-2 pmol of lipid hydroperoxides. Lipid arrays vs. oxidized lipid arrays can be performed by comparing the abundance of phospholipids with the abundance of oxidized phospholipids. Using oxidative lipidomics approach we show that the pattern of phospholipid oxidation during apoptosis is nonrandom and does not follow their abundance in several types of cells undergoing apoptosis and a variety of disease states. This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates.
Abstractions for software-defined networks (2014)

New abstractions are critical for achieving SDN goals.
Nonpeptide endothelin receptor antagonists attenuate the pressor effect of diaspirin-crosslinked hemoglobin in rat (1999)

Endothelin 1 (ET-1) is a potent vasoactive and mitogenic peptide that is thought to participate in the hemodynamic effects elicited by drugs that block the biosynthesis and release of endothelium-derived nitric oxide (NO), such as NO synthase inhibitors. Using the nonpeptide endothelin receptor antagonists bosentan and LU-135252, we tested the hypothesis that endothelins contribute to the pressor activity of diaspirin-crosslinked hemoglobin (DCLHb), a hemoglobin-based oxygen carrier, whose pressor activity in mammals is attributed primarily to a scavenging action towards NO. The NO synthase inhibitor nitro-L-arginine methyl ester (L-NAME), ET-1, and noradrenaline (NA) were used as reference drugs. Bosentan markedly reduced the pressor effects elicited by DCLHb, L-NAME, and ET-1, but not those evoked by NA. LU-135252 attenuated the pressor effect elicited by DCLHb and ET-1, but not that produced by L-NAME or NA. The decreases in heart rate associated with the pressor effect of DCLHb and L-NAME were reduced by LU-135252, whereas only those elicited by DCLHb were attenuated by bosentan. In contrast with bosentan, LU-135252 caused a decrease in the baseline blood pressure and heart rate. These results suggest that endothelins may participate in the pressor activity of DCLHb. They suggest also that nonpeptide endothelin receptor antagonists such as bosentan or LU-135252 may be useful to counteract endothelin-mediated undesirable hemodynamic effects of drugs that inhibit the activity of the NO system.Key words: hemoglobin, endothelin, nitric oxide, blood pressure, diaspirin-crosslinked hemoglobin (DCLHb).
Real world hypoglycaemia related to glucose variability and Flash glucose scan frequency assessed from global FreeStyle Libre data (2022)

The type of CV reported by the different continuous glucose monitoring systems should be acknowledged. CV <36% might not be adequate to ensure low hypoglycaemia exposure. To our knowledge, the majority of continuous glucose monitoring reports the t-CV. Appropriate thresholds should be used to identify patients that would probably meet time below range targets (t-CV <40% or wd-CV <34%).
Quantitative refractive index micro-tomography with Digital Holographic Microscopy: an efficient tool for metrology in nanotechnology and life sciences (2006)

Keywords: [MVD] Reference LOA-CONF-2006-007 Record created on 2009-07-20, modified on 2017-05-10
Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4- d ]pyrimidine derivatives (2015)

A novel series of pyrazolo[3,4- d ]pyrimidine derivatives were designed, synthesized and evaluated for their antiproliferative activity.
Monte-Carlo simulation of the effects of vacuum ultraviolet radiation on electronic materials (2004)

Radiation induced damage during the plasma processing of semiconductor materials adversely affects device reliability. Our group has shown in the past that Vacuum Ultraviolet (VUV) radiation (10nm-200nm) can beneficially deplete the charge deposited on the surface of the semiconductor by temporarily increasing the conductivity of the dielectric. The increase in conductivity has mainly been attributed to the generation of photoemission current and formation of electron hole pairs in the dielectric. In this paper, we discuss the steps involved in developing a model for VUV-semiconductor dielectric interactions based on the well-known Monte Carlo method. The statistical information obtained from this simulation will be compared to the experimental values obtained by exposing silicon nitride wafers to synchrotron radiation of energy 20eV. The simulation predicts the surface potential on the wafer due to photoemission. Experimentally measured surface potentials on the dielectric are used to check the validity of the simulation. Of the different process that can occur when a photon is incident on an atom, we concentrate mainly on photoemission of an electron. Consequently, the elastic and inelastic scattering events experienced by the electron during the course of its motion inside the dielectric are also considered. A modified form of the screened Rutherford formula, which approximates the Mott cross-section, as developed by Browning et. al., has been applied in this simulation. Initial simulation results will be presented.
A Cutoff Waveguide Aperture Antenna With Faraday Shield (1992)

Basic characteristics of a cutoff waveguide aperture antenna used for large scale ICRF (ion cyclotron range of frequency) plasma heating are investigated. Main interests are focused on the effects of the Faraday shield covering the aperture surface. The analysis is performed for the antennas radiating into semi-infinite vacuum space rather than a magnetoplasma to understand the basic characteristics of the antenna where the loading effect due to the presence of the plasma is excluded. Theoretical results show that the input admittance of the aperture antenna with the Faraday shield is similar to that without the shield qualitatively. On the other hand the aperture electric field distribution is quite different for these two cases. The validity of the anisotropic boundary condition which has been often used to incorporate the effects of the Faraday shield is also discussed. In order to confirm the validity of the analysis, experimental results of the input admittance and aperture field are presented.
Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling (2013)

Together, these data identifies the potential hypoxic cell radio-sensitizers and further implies that the induced radio-sensitization may be exerted by selectively targeting IR-induced NFκB signaling.
Optische Grundbegriffe (2014)

No AccessHandbuch Bauelemente der OptikApr 2014Optische GrundbegriffeMartin Löffler-MangMartin Löffler-Manghttps://doi.org/10.3139/9783446441156.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF ShareFacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2014 Pages: 1-18Print ISBN: 978-3-446-42625-2eISBN: 978-3-446-44115-6 Copyright & Permissions© 2014 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Portable Oxygen-Sensing Device for the Improved Assessment of Compartment Syndrome and other Hypoxia-Related Conditions (2020)

Measurement of intramuscular oxygen could play a key role in the early diagnosis of acute compartment syndrome, a common condition occurring after severe trauma leading to ischemia and long-term consequences including rhabdomyolysis, limb loss, and death. However, to date, there is no existing oxygen sensor approved for such a purpose. To address the need to improve the assessment of compartment syndrome, a portable fiber-optic device for intramuscular oxygen measurements was developed. The device is based on phosphorescence quenching, where the tip of an optical fiber was coated with a poly(propyl methacrylate) (PPMA) matrix containing a brightly emitting Pt(II)-core porphyrin. The optoelectronic circuit is highly portable and is based on a microspectrometer and a microcontroller readout with a smartphone. Results from an <i>in vivo</i> tourniquet porcine model show that the sensor is sensitive across the physiological oxygen partial pressure range of 0-80 mmHg and exhibits an appropriate and reproducible response to changes in intramuscular oxygen. A commercial laboratory oxygen sensor based on a lifetime measurement did not respond as expected.
Sealing of Corneal Lacerations Using Photoactivated Rose Bengal Dye and Amniotic Membrane (2017)

The results of these studies established that a light-activated method to cross-link AM to the cornea can be used for sealing complex penetrating wounds in the cornea and sclera with minimal inflammation or secondary effects.
Electrolyte-Phobic Surface for the Next-Generation Nanostructured Battery Electrodes (2020)

Nanostructured electrodes are among the most important candidates for high-capacity battery chemistry. However, the high surface area they possess causes serious issues. First, it would decrease the Coulombic efficiencies. Second, they have significant intakes of liquid electrolytes, which reduce the energy density and increase the battery cost. Third, solid-electrolyte interphase growth is accelerated, affecting the cycling stability. Therefore, the interphase chemistry regarding electrolyte contact is crucial, which was rarely studied. Here, we present a completely new strategy of limiting effective surface area by introducing an "electrolyte-phobic surface". Using this method, the electrolyte intake was limited. The initial Coulombic efficiencies were increased up to ∼88%, compared to ∼60% of the control. The electrolyte-phobic layer of Si particles is also compatible with the binder, stabilizing the electrode for long-term cycling. This study advances the understanding of interphase chemistry, and the introduction of the universal concept of electrolyte-phobicity benefits the next-generation battery designs.
Erythropoietin or Darbepoetin for patients with cancer (2006)

There is consistent evidence that administration of Epo/Darbepo reduces the relative risk for blood transfusions and the number of units transfused in cancer patients. For patients with baseline haemoglobin below 12 g/dL (mild anaemia) there is strong evidence that Epo/Darbepo improves haematological response. There is suggestive evidence that Epo/Darbepo may improve QoL. However, there is strong evidence that Epo/Darbepo increases the relative risk for thrombo embolic complications. Whether and how Epo/Darbepo effects tumour response and overall survival remains uncertain.
X-Ray Diffraction Studies of FeRh0.38Pd0.62Alloy with Orthorhombic Structure (1995)

The crystalline structure of FeRh 0.38 Pd 0.62 alloy was examined by means of X-ray diffractometry. In this alloy, a new ferromagnetic phase was found below 265 K in the matrix body-centered tetragonal phase. The low-temperature phase has an orthorhombic structure (space group: C mmm ). The Fe atoms on 4i sites of the orthorhombic structure are displaced along the b -axis, while the Rh and Pd atoms on 4j sites are displaced along the a -axis.
Increased Sensitivity of Dopaminergic Inhibition of Luteinizing Hormone Release in Immature and Castrated Female Rats (1978)

Apomorphine, a dopamine receptor-stimulating drug, at a dose of 5 mg/kg BW was highly effective in reducing serum LH levels in chronically ovariectomized rats. Continued treatment of the same rats with a depot form of this drug (dibutyrylapomorphine (ZK 48241)) twice daily for 10 days resulted in depressed LH levels for a period of 3 days. By day 9, serum LH levels were normal and could not be depressed by another injection of apomorphine (5 mg/kg BW). The first injection of apomorphine had no effect on serum FSH levels; however, chronic treatment with ZK 48241 caused serum FSH to rise throughout the remainder of the 10-day period. Serum prolactin levels were depressed by the acute apomorphine treatment as well as during the period of ZK 48241 treatment. Apomorphine as well as piribedil (another dopamine receptor-stimulating drug) at doses of 1 or 10 mg/kg BW completely prevented the occurrence of premature preovulatory-type LH peaks when injected at noon into 15-day old female rats. Serum FSH remained unchanged at high levels. Both doses of piribedil proved to be ineffective in blocking the preovulatory LH peak in adult proestrous rats. These results suggest that a dopamine receptor mechanism which is inhibitory to LH but not to FSH release is highly sensitive in 15-day-old female rats but very insensitive in adult proestrous rats. In chronically ovariectomized adult rats, this dopamine-sensitive receptor is resensitized and can be desensitized by chronic treatment with dopamine receptor stimulating drugs. (Endocrinology102: 837, 1978)
Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the bone marrow in patients with myelodysplastic syndromes: correlation between VEGF expression and the FAB category (2006)

Recent data suggest that vascular endothelial growth factor (VEGF) is produced in neoplastic cells in various myeloid neoplasms and plays a key role as an autocrine regulator and mediator of angiogenesis. We examined the expression of VEGF in paraffin-embedded bone marrow sections obtained from normal donors (n = 5) and 46 patients with myelodysplastic syndromes [MDS, French-American-British (FAB)-type refractory anemia (RA), n = 10; refractory anemia with ringed sideroblasts (RARS), n = 10; refractory anemia with excess blasts (RAEB), n = 10; RAEB in transformation (RAEB-T), n = 8; chronic myelomonocytic leukemia (CMML), n = 8] by immunohistochemistry using an anti-VEGF antibody. In normal bone marrow, the anti-VEGF antibody was found to react with myeloid progenitor cells, immature monocytic cells, plasma cells and megakaryocytes, but not with erythroid cells or mature granulocytic cells. Higher levels of VEGF were found in patients with MDS, subtypes RAEB, RAEB-T and CMML, compared to patients with RA or RARS, or the normal bone marrow. These differences were found to result from expression of VEGF in immature myeloid cells in RAEB, RAEB-T and CMML. The microvessel density was also higher in patients with RAEB-T and CMML compared to RA and RARS or the normal bone marrow. Expression of VEGF mRNA was demonstrable in isolated neoplastic cells by reverse transcriptase-polymerase chain reaction in all patients examined. In aggregate, these data show that VEGF is expressed in bone marrow cells in patients with MDS. The amount of expressed VEGF is related to the percentage of immature myeloid cells (blasts and monocytic progenitors) and correlates with the FAB category.
SEPP: Similarity Estimation of Predicted Probabilities for Defending and Detecting Adversarial Text (2021)

There are two cases describing how a classifier processes input text, namely, misclassification and correct classification. In terms of misclassified texts, a classifier handles the texts with both incorrect predictions and adversarial texts, which are generated to fool the classifier, which is called a victim. Both types are misunderstood by the victim, but they can still be recognized by other classifiers. This induces large gaps in predicted probabilities between the victim and the other classifiers. In contrast, text correctly classified by the victim is often successfully predicted by the others and induces small gaps. In this paper, we propose an ensemble model based on similarity estimation of predicted probabilities (SEPP) to exploit the large gaps in the misclassified predictions in contrast to small gaps in the correct classification. SEPP then corrects the incorrect predictions of the misclassified texts. We demonstrate the resilience of SEPP in defending and detecting adversarial texts through different types of victim classifiers, classification tasks, and adversarial attacks.
Active Isolation and Damping of Vibrations for High Precision Laser Cutting Machine (2011)

High precision industrial machines suffer the presence of vibrations due to several noise sources: ground vibration, acoustic noise, direct force disturbances. These are sources of several problems at different levels and of different natures causing the performance losses on sensitive systems (Crede, 1951), (Rivin, 1979). In the last years the need of higher processing quality and throughput resulted in a continuing demand for higher accuracy. Therefore active isolation and vibration damping systems became mandatory to satisfy these requests (Preumont, 2002), (Hyde, 1997). In general, machine supports are designed for high stiffness to obtain a robust machine alignment with respect to its surroundings. However, in the presence of significant ground vibration levels the support stiffness is commonly sacrificed to reduce the transmission to the payload stage. Efforts to go towards these issues are recorded in several applications and the solutions are different for any particular situation, depending on the nature of the vibration sources, the amount of the disturbances and the machine environment. Three main categories of possible approaches can be identified: passive, active and semiactive configurations. Completely passive solutions have almost reached their maximum potential which is still not sufficient to satisfy stringent requirements. On the opposite, the exponential growth in electronics and actuators fields made the use of active and semi-active isolation more feasible. In particular, active control architectures allow to perform an effective isolation at low frequencies, which is a common requirement for very demanding applications like micrometer motion control, defect inspections, critical dimensions measurement and overlay metrology. Active control arrangements are provided with sensors, actuators and controllers (Watters, 1988). Each of them can be classified depending on their technology and physical working principle. For the application considered in this work, the main categories of sensors used are: displacement, velocity, acceleration, strain and force. In the same way, the most common types of actuators are: shape memory alloys, magnetic, piezoelectric, magnetostrictive and magneto-rheological fluids actuators (Thayer, 1998). The choice of sensors and actuators is strictly related to the type of application and requirements and has also influence on the selection of the control strategies to be
Process Evaluation of a Fully Automated Molecular Diagnostics System (2009)

Molecular diagnostics presents challenges to clinical laboratories that are under pressure to consolidate and automate. There is a need to evaluate molecular automation for process efficiency and suitability for high-throughput environments in core laboratories. A fully automated molecular instrument platform (the BD Viper System with XTR Technology in extracted mode [BD Viper System with XTR]), was evaluated for automation efficiency, labor requirements, and system robustness. System productivity was predicted using time and motion studies as well as process simulation. Preanalytical steps required 15 min of skilled operator time. The BD Viper System with XTR fully automated DNA extraction, amplification, and analysis of 368 specimens (736 results for Chlamydia and Gonorrhea). Time and motion studies estimated that the total hands-on full time employee (FTE) burden was approximately 35 min per run, of which 41% was high complexity, 29% medium complexity and 29% relatively unskilled labor. A skilled operator can easily operate four instruments for 8.5 h and generate data on 2944 results (four runs on each instrument for a total of 1472 clinical specimens) for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) analysis. Based on mean time between intervention data, the BD Viper System with XTR was estimated to be capable of operating for more than 1000 runs without system malfunction. We determined that fully automated molecular analysis of GC and CT is possible in a core laboratory facility with significant throughput and minimal impact on labor demand using a fully automated and robust molecular diagnostics platform (such as the BD Viper System with XTR).
Model of Water Sorption and Swelling in Polymer Electrolyte Membranes: Diagnostic Applications (2015)

This work expands on the poroelectroelastic model of water sorption in polymer electrolyte membranes. It links membrane water sorption and the evolution of the pore size distribution with the microscopic charge density distribution at pore surfaces and the microscopic shear modulus of polymeric pore walls. We evaluate different deformation modes of polymeric pore walls to derive stress-strain relationships that determine the law of swelling. Thereafter, the model is applied to different sets of water sorption data for membranes that were submitted to either hygrothermal aging or chemical degradation. The model-based analysis relates the macroscopic state of swelling to the evolution of the statistical distribution of the pore radius as well as of the microscopic fluid and elastic pressures. Changes in the surface charge density at pore surfaces and elastic pressure of pore walls, induced by degradation, can be rationalized. These insights are useful in view of understanding degradation mechanisms and their structural effects.