gebhart/patrepeval huggingface dataset:
[Usefulness of ultrasonography in the diagnosis of portal hypertension]. (1998)

Portal hypertension syndrome is a common evolutive complication of several hepatic and extrahepatic diseases, being liver cirrhosis responsible for more than 80% of cases. When diagnosed it has prognostic value because of the high incidence of hemorrhagic, metabolic and infectious complications that these patients may develop. Clinical suspicion must be confirmed by objective complementary studies that provide information about the etiology and severity of the disease. In this review article we describe the contribution of ultrasonography in the evaluation of patients with portal hypertension as an objective diagnostic method and the usefulness of doppler ultrasound in the non-invasive hemodynamic assessment of the splanchnic and portal circulation.
Ensemble Transfer Learning of Elastography and B-mode Breast Ultrasound Images (2021)

Computer-aided detection (CAD) of benign and malignant breast lesions becomes increasingly essential in breast ultrasound (US) imaging. The CAD systems rely on imaging features identified by the medical experts for their performance, whereas deep learning (DL) methods automatically extract features from the data. The challenge of the DL is the insufficiency of breast US images available to train the DL models. Here, we present an ensemble transfer learning model to classify benign and malignant breast tumors using B-mode breast US (B-US) and strain elastography breast US (SE-US) images. This model combines semantic features from AlexNet &amp; ResNet models to classify benign from malignant tumors. We use both B-US and SE-US images to train the model and classify the tumors. We retrospectively gathered 85 patients' data, with 42 benign and 43 malignant cases confirmed with the biopsy. Each patient had multiple B-US and their corresponding SE-US images, and the total dataset contained 261 B-US images and 261 SE-US images. Experimental results show that our ensemble model achieves a sensitivity of 88.89% and specificity of 91.10%. These diagnostic performances of the proposed method are equivalent to or better than manual identification. Thus, our proposed ensemble learning method would facilitate detecting early breast cancer, reliably improving patient care.
Measurement of Plasma Flows in IMS (1995)

Mach probe measurements of bias-induced ion flows were made in the Interchangeable Module Stellarator (IMS) as a function of neutral pressure and viscosity (which increases with minor radius) and compared to a fluid theory model. Using a probe model for an unmagnetized plasma, the poloidal flow speed measured with a Mach probe agrees with that calculated from momentum balance to within 15%. The dependencies of the measured ion flow magnitudes and decay rates on neutral pressure and viscosity as predicted by the theory are qualitatively observed in the experimental measurements, clearly demonstrating the effects of both ion-neutral collisions and viscosity in the damping of the bias-induced flows. However, the measured flow direction is nearly poloidal, while the theory predicts a predominantly Pfirsch-Schlüter-like toroidal flow. Also, the two-dimensional variation at a constant toroidal angle of the parallel electron current was measured in an unbiased plasma. The measured profiles demonstrate the dependence of the current on both the radial pressure gradient and the cosine of the poloidal angle, as predicted by theory.
Curcuminoids andBoswellia serrataextracts combination decreases tendinopathy symptoms: findings from an open-label post-observational study (2020)

<b>Background:</b> To investigate the effects of 1-month treatment in addition to standard care with a food supplement containing both <i>Curcuma longa</i> and <i>Boswellia serrata</i> extracts on tendinopathy symptoms.<b>Method:</b> This open-label, non-controlled, post-observational study included 670 patients suffering from tendinopathy recruited at different sites by Belgian general practitioners. Patients received a medical prescription for 1-month treatment with two tablets twice a day of a pharmaceutical grade food supplement containing both <i>C. longa</i> and <i>B. serrata</i> extracts. Pain and functional limitation were evaluated using a visual analog scale at the inclusion and 1-month treatment later. Patient satisfaction, concomitant drugs intake and side effects were also recorded.<b>Results:</b> After 1-month treatment, pain and functional limitation were significantly improved whatever the cause of tendinopathy, its localization, and the duration of symptoms. The pain score decreased from 6.16 ± 1.53 to 2.98 ± 1.64 (<i>p</i> < .0001), yielding a drop of 51.6% and the functional limitation score fell after 1-month treatment from 5.96 ± 1.73 to 2.88 ± 1.67 (<i>p</i> < .0001) corresponding to a drop of 51.6%. The percentage of patients taking at least one concomitant treatment at the end of the treatment period had decreased from 81.3% to 61.8% (<i>p</i> < .0001). Only 43 (6.5%) patients reported side effects. No severe adverse effects related to the product were reported.<b>Conclusion:</b> The combination of <i>C. longa</i> and <i>B. serrata</i> extracts improves symptoms in patients suffering of tendinopathy and shows a good safety. Although its effect will have to be confirmed in randomized controlled trials, it can be considered as a helpful support of standard symptomatic treatments for tendinopathies. HighlightsTendinopathy is a common disease representing 30% of all consultations with a general practitioner for musculoskeletal disorders.The combination of Curcuminoids and <i>Boswellia</i><i>serrata</i> extracts are efficient on tendinopathy symptoms in support of standard symptomatic treatments.The combination of Curcuminoids and <i>B. Serrata</i> extract is safe and can be administrated for at least 1 month in addition of analgesic and non-steroidal anti-inflammatory drugs.
Practical learning method for multi-scale entangled states (2012)

We describe a method for reconstructing multi-scale entangled states from a small number of efficiently-implementable measurements and fast post-processing. The method only requires single particle measurements and the total number of measurements is polynomial in the number of particles. Data post-processing for state reconstruction uses standard tools, namely matrix diagonalisation and conjugate gradient method, and scales polynomially with the number of particles. Our method prevents the build-up of errors from both numerical and experimental imperfections.
Supplementary Figure 1 from Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors (2023)

Supplementary Figure 1 from Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors
An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins (2020)

A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linkers with low levels of spontaneous hydrolysis but increased level of hydrolysis with rising concentrations of glucose, which demonstrated their glucose responsiveness in vitro. Lipidated hydrazones and thiazolidines were conjugated to the LysB29 side-chain of HI by pH-controlled acylations providing GRIs with glucose responsiveness confirmed in vitro for thiazolidines. Clamp studies showed increased glucose infusion at hyperglycemic conditions for one GRI indicative of a true glucose response. The glucose responsive cleavable linker in these GRIs allow changes in glucose levels to drive the release of active insulin from a circulating depot. We have demonstrated an unprecedented, chemically responsive linker concept for biopharmaceuticals.
Quantification of cyclosporin G (NVa2 cyclosporin) by radioimmunoassay. (1986)

Journal Article Quantification of cyclosporin G (NVa2 cyclosporin) by radioimmunoassay. Get access R W Yatscoff, R W Yatscoff Search for other works by this author on: Oxford Academic Google Scholar J R Jeffery J R Jeffery Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 32, Issue 4, 1 April 1986, Pages 700–701, https://doi.org/10.1093/clinchem/32.4.700b Published: 01 April 1986
Triboluminescence and Metal Phosphor for Organic Light-Emitting Diodes: Functional Pt(II) Complexes with Both 2-Pyridylimidazol-2-ylidene and Bipyrazolate Chelates (2016)

We report the utilization of both pyrid-2-yl-imidazolylidene and dianionic bipz chelates as constituents in syntheses of a new series of charge-neutral Pt(II) complexes 1-4, among which complex 4 revealed remarkable triboluminescence, i.e., generation of photoemission upon grinding or cracking of the solid sample. The triboluminescence is found to be sensitive to the subtle changes of the associated substituents of pyrid-2-yl-imidazolylidene chelate, as verified by the disappearance of the triboluminescence for complexes 1-3. Alternatively, the well-ordered solid packing of 3, as indicated by the grazing incidence X-ray scattering experiment, serves as an ideal emitter for the fabrication of highly efficient OLEDs, rendering high external quantum efficienciy (25.9%) and luminesce efficiency (90 cd A<sup>-1</sup>) at the practical brightness of 100 cd m<sup>-2</sup>. The rather low roll-off in efficiency (24.4%, 85 cd A<sup>-1</sup> at high brightness of 1000 cd m<sup>-2</sup>) is attributed to the short excited-state lifetime of 3 (∼800 ns) in the solid state, which in turn is associated with the MMLCT transition character.
Direction matters: Depth estimation with a surface normal classifier (2015)

In this work we make use of recent advances in data driven classification to improve standard approaches for binocular stereo matching and single view depth estimation. Surface normal direction estimation has become feasible and shown to work reliably on state of the art benchmark datasets. Information about the surface orientation contributes crucial information about the scene geometry in cases where standard approaches struggle. We describe, how the responses of such a classifier can be included in global stereo matching approaches. One of the strengths of our approach is, that we can use the classifier responses for a whole set of directions and let the final optimization decide about the surface orientation. This is important in cases where based on the classifier, multiple different surface orientations seem likely. We evaluate our method on two challenging real-world datasets for the two proposed applications. For the binocular stereo matching we use road scene imagery taken from a car and for the single view depth estimation we use images taken in indoor environments.
Implementing the CAM-I Application Interface Specification With UNIX Interprocess Communication (1992)

Abstract The CAM-I Application Interface Specification (AIS) allows applications to access a geometric modeler for model analysis using a standardized interface. This is accomplished by linking the source or object codes of the application and modeler together at compile time along with the AIS implementation for the modeler. This methodology requires at least the object code of both programs and results in a single, large executable program dedicated to the use of the specific application and modeler only. By using interprocess communication (IPC) with the AIS, the two programs can remain separate and be used with other modelers and applications rather than only with each other. The approach used in defining the AIS/IPC adaptation issues and developing and testing concepts to address those issues resulted in successfully implementing AIS using the messaging routines of IPC. This allowed an independent application to invoke and interface with an independent geometric modeler and perform analyses on representative models. The implications of the approach used and the implementation of AIS with IPC in engineering are broad. Using a modified form of the AIS/IPC, an application could theoretically interface with a modeler on a remote system far from the host.
(S)-(−)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice (2001)

(S)-(-)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.
Waterbomb base: a symmetric single-vertex bistable origami mechanism (2014)

The origami waterbomb base is a single-vertex bistable origami mechanism that has unique properties which may prove useful in a variety of applications. It also shows promise as a test bed for smart materials and actuation because of its straightforward geometry and multiple phases of motion, ranging from simple to more complex. This study develops a quantitative understanding of the symmetric waterbomb base's kinetic behavior. This is done by completing kinematic and potential energy analyses to understand and predict bistable behavior. A physical prototype is constructed and tested to validate the results of the analyses. Finite element and virtual work analyses based on the prototype are used to explore the locations of the stable equilibrium positions and the force–deflection response. The model results are verified through comparisons to measurements on a physical prototype. The resulting models describe waterbomb base behavior and provide an engineering tool for application development.
Resource Co-Allocation in Grid Computing Environments (2012)

One of the promises of Grid Computing is to enable the execution of applications across multiple sites. Several multi-site applications require simultaneous access to resources hosted on autonomous domains; this problem is known as resource co-allocation. Projects working on resource co-allocation face four major problems: distributed transactions, fault tolerance, inter-site network overhead, and schedule optimization. Although resource co-allocation is fundamental for Grid Computing, no survey has covered the current projects, solutions, and open challenges on this topic. Therefore, in this chapter, the authors describe the challenges on resource co-allocation, present the projects developed over the last decade, and classify them according to their similar characteristics. In addition, the authors discuss open research issues and trends such as negotiation, advance reservations, and rescheduling of multi-site applications.
Method of manufacturing metallic products such as sheet by cold working and flash annealing (2023)

A metallic alloy composition is manufactured into products such as press formed or stamped products or rolled products such as sheet, strip, rod, wire or band by one or more cold working steps with intermediate or final flash annealing. The method can include cold rolling an iron, nickel or titanium aluminide alloy and annealing the cold worked product in a furnace by infrared heating. The flash annealing is preferably carried out by rapidly heating the cold worked product to an elevated temperature for less than one minute. The flash annealing is effective to reduce surface hardness of the cold worked product sufficiently to allow further cold working. The product to be cold worked can be prepared by casting the alloy or by a powder metallurgical technique such as tape casting a mixture of metal powder and a binder, roll compacting a mixture of the powder and a binder or plasma spraying the powder onto a substrate. In the case of tape casting or roll compaction, the initial powder product can be heated to a temperature sufficient to remove volatile components. The method can be used to form a cold rolled sheet which is formed into an electrical resistance heating element capable of heating to 900.degree. C. in less than 1 second when a voltage up to 10 volts and up to 6 amps is passed through the heating element.
Interactions of Francisella tularensis with Alveolar Type II Epithelial Cells and the Murine Respiratory Epithelium (2015)

Francisella tularensis is classified as a Tier 1 select agent by the CDC due to its low infectious dose and the possibility that the organism can be used as a bioweapon. The low dose of infection suggests that Francisella is unusually efficient at evading host defenses. Although ~50 cfu are necessary to cause human respiratory infection, the early interactions of virulent Francisella with the lung environment are not well understood. To provide additional insights into these interactions during early Francisella infection of mice, we performed TEM analysis on mouse lungs infected with F. tularensis strains Schu S4, LVS and the O-antigen mutant Schu S4 waaY::TrgTn. For all three strains, the majority of the bacteria that we could detect were observed within alveolar type II epithelial cells at 16 hours post infection. Although there were no detectable differences in the amount of bacteria within an infected cell between the three strains, there was a significant increase in the amount of cellular debris observed in the air spaces of the lungs in the Schu S4 waaY::TrgTn mutant compared to either the Schu S4 or LVS strain. We also studied the interactions of Francisella strains with human AT-II cells in vitro by characterizing the ability of these three strains to invade and replicate within these cells. Gentamicin assay and confocal microscopy both confirmed that F. tularensis Schu S4 replicated robustly within these cells while F. tularensis LVS displayed significantly lower levels of growth over 24 hours, although the strain was able to enter these cells at about the same level as Schu S4 (1 organism per cell), as determined by confocal imaging. The Schu S4 waaY::TrgTn mutant that we have previously described as attenuated for growth in macrophages and mouse virulence displayed interesting properties as well. This mutant induced significant airway inflammation (cell debris) and had an attenuated growth phenotype in the human AT-II cells. These data extend our understanding of early Francisella infection by demonstrating that Francisella enter significant numbers of AT-II cells within the lung and that the capsule and LPS of wild type Schu S4 helps prevent murine lung damage during infection. Furthermore, our data identified that human AT-II cells allow growth of Schu S4, but these same cells supported poor growth of the attenuated LVS strain in vitro. Collectively, these data further our understanding of the role of AT-II cells in Francisella infections.
Second autologous haematopoietic stem cell transplantation in systemic sclerosis—a case report (2019)

of microvascular involvement, compared with a classical NVC pattern definition showing longer time to progression between different patterns In our study we found very low levels of VEGF-A but high levels of E-Selectin and VCAM-1. A plausible explanation of this finding might be the large variability observed in serum levels of these molecules when compared between different studies However, we observed a significant improvement of microvascular involvement achieved with 3 months of HCQ treatment. This is a novel finding in SSc, which could represent a new therapeutic possibility for the prevention of microvascular complications of the disease.
Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation (1998)

Several ion channels are reportedly redox responsive, but the molecular basis for the changes in activity is not known. The mechanism of nitric oxide action on the cardiac calcium release channel (ryanodine receptor) (CRC) in canines was explored. This tetrameric channel contains approximately 84 free thiols and is S-nitrosylated in vivo. S-Nitrosylation of up to 12 sites (3 per CRC subunit) led to progressive channel activation that was reversed by denitrosylation. In contrast, oxidation of 20 to 24 thiols per CRC (5 or 6 per subunit) had no effect on channel function. Oxidation of additional thiols (or of another class of thiols) produced irreversible activation. The CRC thus appears to be regulated by poly-S-nitrosylation (multiple covalent attachments), whereas oxidation can lead to loss of control. These results reveal that ion channels can differentiate nitrosative from oxidative signals and indicate that the CRC is regulated by posttranslational chemical modification(s) of sulfurs.
Clinical responses of head & neck tumors to radiation therapy by NIR spectroscopy (2004)

The aim is to evaluate the usefulness of NIR spectroscopy for predicting early tumor response to radiation therapy in patients with head and neck tumors. The results suggest a correlation between tumor oxygenation and clinical outcome.
IMMOBILIZATION OF ANTIMICROBIAL BACTERIAL SUBSTANCES ONTO POLYMERIC MATRICES: THEIR PROPERTY EVALUATION (2016)

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DPAL: A new class of lasers for cw power beaming at ideal photovoltaic cell wavelengths (2004)

The new class of diode pumped alkali vapor lasers (DPALs) offers high efficiency cw laser beams at wavelengths which efficiently couple to photovoltaic (PV) cells: silicon cells at 895 nm (cesium), and GaAs cells at 795 nm (rubidium) and at 770 nm (potassium). DPAL electrical efficiencies of 25–30% are projected, enabling PV cell efficiencies ∼40% (Si) and ∼60% (GaAs). Near‐diffraction‐limited DPAL device power scaling into the multi‐kilowatt regime from a single aperture is projected. The potential application to power beaming propulsion to raise satellites from LEO to Geo is discussed.
Influence of large-scale motions on the frictional drag in a turbulent boundary layer (2017)

Direct numerical simulation data of a turbulent boundary layer ( $Re_{\unicode[STIX]{x1D70F}}=1000$ ) were used to investigate the large-scale influences on the vortical structures that contribute to the local skin friction. The amplitudes of the streamwise and wall-normal swirling strengths ( $\unicode[STIX]{x1D706}_{x}$ and $\unicode[STIX]{x1D706}_{y}$ ) were conditionally sampled by measuring the large-scale streamwise velocity fluctuations ( $u_{l}$ ). In the near-wall region, the amplitudes of $\unicode[STIX]{x1D706}_{x}$ and $\unicode[STIX]{x1D706}_{y}$ decreased under negative $u_{l}$ rather than under positive $u_{l}$ . This behaviour arose from the spanwise motions within the footprints of the large-scale low-speed ( $u_{l}&lt;0$ ) and high-speed structures ( $u_{l}&gt;0$ ). The intense spanwise motions under the footprint of positive $u_{l}$ noticeably strengthened the small-scale spanwise velocity fluctuations ( $w_{s}$ ) below the centre of the near-wall vortical structures as compared to $w_{s}$ within the footprint of negative $u_{l}$ . The streamwise and wall-normal components were attenuated or amplified around the modulated vortical motions, which in turn led to the dependence of the swirling strength on the $u_{l}$ event. We quantified the contribution of the modulated vortical motions $\langle -w\unicode[STIX]{x1D714}_{y}\rangle$ , which were related to a change-of-scale effect due to the vortex-stretching force, to the local skin friction. In the near-wall region, intense values of $\langle -w\unicode[STIX]{x1D714}_{y}\rangle$ were observed for positive $u_{l}$ . By contrast, these values were low for negative $u_{l}$ , in connection with the amplification of $w_{s}$ and $\unicode[STIX]{x1D706}_{y}$ by the strong spanwise motions of the positive $u_{l}$ . The resultant skin friction induced by the amplified vortical motions within $u_{l}^{+}&gt;2$ was responsible for 15 % of the total skin friction generated by the change-of-scale effect. Finally, we applied this analysis to a drag-reduced flow and found that the amplified vortical motions within the footprint of positive $u_{l}$ were markedly diminished, which ultimately contributed to the total drag reduction.