gebhart/patrepeval huggingface dataset:
High-Performance Megahertz-Frequency Resonant DC–DC Converter for Automotive LED Driver Applications (2020)

This paper introduces a megahertz-frequency resonant dc-dc converter that inherently achieves a load-independent output current while maintaining high efficiency across a wide output voltage range. These properties make the proposed converter well-suited for automotive light-emitting diode (LED) driver applications, where a varying number of LEDs need to be driven with a constant current. The proposed converter achieves load-independent output current by utilizing an LCL-T resonant network, and achieves high efficiency using a comprehensive design optimization methodology. This LCL-T resonant converter is also capable of regulating its output current at any desired value by utilizing phase-shift control. The performance of the LCL-T resonant converter is theoretically and experimentally compared with an LC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> L and an LCLC resonant converter. For the experimental comparison, prototypes LCL-T, LC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> L, and LCLC resonant converters are designed to operate at 2 MHz and across an output voltage range of 3.3-49.5 V while supplying a constant 0.5 A output current to the LEDs. The LCL-T resonant converter prototype achieves a peak efficiency of 91.1%, which is 0.6% and 1.8% higher than the peak efficiency of the LC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> L and the LCLC converter prototypes, respectively. Furthermore, the LCL-T converter prototype maintains 0.8% and 1.6% higher average efficiency over its 15:1 output voltage range relative to the LC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> L and the LCLC converter prototypes, respectively.
Portable Implementation of Lattice-Based Cryptography Using JavaScript (2015)

Lattice-based cryptography has attracted a high degree of attention in the cryptologic research community. It is expected to be in wide use in the foreseeable future once large quantum computers are in sight. In addition, JavaScript is a standard programming language for Web applications. It is now supported on a wide variety of computing platforms and devices with immense efficiency improvement in the past few years. In this paper, we present the results of our JavaScript implementation of several Lattice-based encryption schemes and show the speed performance on four common Web browsers on PC. Furthermore, we also show the performance on two smaller computing platforms, namely, tablets running the Android operating system, as well as Tessel, an embedded system equipped with an ARM Cortex-M3-grade microcontroller. Our results demonstrate that some of today's Lattice-based cryptosystems can already have efficient JavaScript implementations and hence are ready for use on a growing list of JavaScript-enabled computing platforms.
Sensorless force control using H∞ acceleration controller (2002)

This paper proposes manipulator force control without a force sensor. The proposed force control system is designed with an H/spl infin/ acceleration controller and a reaction force estimation system. The H/spl infin/ acceleration controller realizes a fine and robust motion control. The reaction force estimation system consists of a torque observer and inverse dynamics calculation, and its estimated value is fed to the force control system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs (2023)

Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for Zn(II)-dependent metalloenzymes including human carbonic anhydrase II (hCAII) and matrix metalloproteinase-2 (MMP-2).
HealthAdvisor: Recommendation System for Wearable Technologies enabling\n Proactive Health Monitoring (2016)

Proactive monitoring of one's health could avoid serious diseases as well as\nbetter maintain the individual's well-being. In today's IoT world, there has\nbeen numerous wearable technological devices to monitor/measure different\nhealth attributes. However, with that increasing number of attributes and\nwearables, it becomes unclear to the individual which ones they should be\nusing. The aim of this paper is to provide a recommendation engine for\npersonalized recommended wearables for any given individual. The way the engine\nworks is through first identifying the diseases that this person is at risk of,\ngiven his/her attributes and medical history. We built a machine learning\nclassification model for this task. Second, these diseases are mapped to the\nattributes that need to be measured in order to monitor such diseases. Third,\nwe map these measurements to the appropriate wearable technologies. This is\ndone via a textual analytics model that we developed that uses available\ninformation of different wearables to map the aforementioned measurements to\nthese wearables. The output can be used to recommend the wearables to\nindividuals as well as provide a feedback to wearable developers for common\nmeasurements that do not have corresponding wearables today.\n
ChemInform Abstract: A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes. (2014)

Abstract The starting material (I) is synthesized beginning with the difluorination of cycloheptane‐1,3‐dione using Selectfluor, mono‐Wittig olefination and hydrogenation of the olefin moiety.
Metal-gate/high-&#x043A; CMOS scaling from Si to Ge at small EOT (2010)

Continuously down-scaling EOT and improving mobility are required for CMOS device. Small 0.6~1 nm EOT and low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> of ~0.15 V are achieved in CMOS by using higher κ gate dielectric and novel process. The ultimate EOT scaling is limited by the inserted ultra-thin SiON interfacial layer in high-κ/Si to reduce the mobility degradation. Further mobility improvement is obtained by using Ge channel MOSFET that has 2.5X better high-field hole effective mobility than the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si universal mobility at an E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> of 1 MV/cm.
Mucins and their receptors in chronic lung disease (2020)

There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality. Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis. The aim of this review is to familiarise the reader with the role of mucins in both lung health and disease, with particular focus on function in immunity, infection and inflammation. We will also discuss their receptors, termed glycan-binding proteins, and how they provide an attractive prospect for therapeutic intervention.
ChemInform Abstract: Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible‐Light‐Activated Photoredox Catalysis with a Chiral Rhodium Complex. (2016)

Abstract The development of photoredox conditions for the high‐yielding highly enantioselective addition of benzylic, alkoxylic as well as secondary and tertiary aliphatic trifluoroborates to the alkene moiety of 2‐alkeneacyl substituted imidazoles or pyrazole derivatives is described.
Inverse scattering analysis with an acoustic time-reversal mirror (1994)

Time-reversal mirror (TRM) utilizes time-reversal invariance of wave equation. Acoustic TRM are made of large transducer arrays allowing the incident acoustic field to be sampled, time reversed, and reemitted. The ability of TRM to time reverse separately each scattered wave permits us to isolate spatially and temporally the equivalent sources of extended scatterer illuminated by broadband pulse. We investigate more particulary the problem of a cylindrical scatterer: We show that TRM allows us to determine the location of the mode conversions of incident waves into circumferential waves.
Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP (2018)

Mucositis is an inflammatory condition of the gut, caused by an adverse effect of chemotherapy drugs, such as 5-fluorouracil (5-FU). In an attempt to develop alternative treatments for the disease, several research groups have proposed the use of probiotics, in particular, Lactic Acid Bacteria (LAB). In this context, the use of recombinant LAB, for delivering anti-inflammatory compounds has also been explored. In previous work, we demonstrated that either Lactococcus lactis NZ9000 or a recombinant strain expressing an antimicrobial peptide involved in human gut homeostasis, the Pancreatitis-associated Protein (PAP), could ameliorate 5-FU-induced mucositis in mice. However, the impact of these strains on the gut microbiota still needs to be elucidated. Therefore, in the present study, we aimed to characterize the effects of both Lactococci strains in the gut microbiome of mice through a 16 S rRNA gene sequencing metagenomic approach. Our data show 5-FU caused a significant decrease in protective bacteria and increase of several bacteria associated with pro-inflammatory traits. The Lactococci strains were shown to reduce several potential opportunistic microbes, while PAP delivery was able to suppress the growth of Enterobacteriaceae during inflammation. We conclude the strain secreting antimicrobial PAP was more effective in the control of 5-FU-dysbiosis.
MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines (2012)

Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.
A search for pair production of new light bosons decaying into muons (2015)

A search for the pair production of new light bosons, each decaying into a pair of muons, is performed with the CMS experiment at the LHC, using a dataset corresponding to an integrated luminosity of 20.7 fb -1 collected in proton-proton collisions at center-of-mass energy of
Analysis of blood clot formation with transient elastography: similarity with sol-gel transition in agar-gelatin phantoms. (2005)

Blood coagulation plays an important role in many cardiovascular diseases like atherosclerosis, heart stroke and deep vein thrombosis. The characterization of blood clot mechanical properties is fundamental in determining the appropriate treatment and for understanding the etiology of these pathologies. Intuitively, the blood coagulation can be considered as a transition from a liquid to a solid state. This behavior seems to be very close to the sol-gel transition in polymer mixture. In this paper, the validity of transient elastography to follow-up the sol-gel transition of an agar-gelatin mixture is shown. The results obtained are in good agreement with the literature and theoretical predictions. Experiments were also performed on blood pig samples in vitro. The analogy between the viscoelastic behavior of the polymer mixture and that of blood clot formation as a function of time is discussed and shown to be similar.
Selective Inhibition of HDAC6 Decreases Viability of Cutaneous T-Cell Lymphoma and Improves Immune Recognition (2014)

Abstract Cutaneous T-cell lymphoma (CTCL) includes a spectrum of non-Hodgkin’s T-cell lymphomas. While most patients with CTCL experience non-life threatening skin symptoms, those who do progress to later stages of the disease may develop serious complications. For patients with tumor stage or lymph node involvement there is a significant decline in treatment response &amp; few treatment options are available. Current available therapeutic options include the use of histone deacetylase (HDAC) inhibitors as Romidepsin, Panobinostat and Vorinostat. However, their mechanism of action is still unknown. The role of histone deacetylases (HDACs) in cell biology, initially limited to their effects upon histones, now encompasses more complex regulatory functions that are dependent on their tissue expression, cellular compartment distribution, pathophysiological conditions and stage of cellular differentiation. Although major advances have been made in understanding the role of specific HDACs in cell proliferation and the survival of cancer cells, their individual participation in specific intracellular pathways is not completely understood. Here we present data demonstrating the changes in several immune-related pathways in two CTCL cell lines after exposure to both pan-HDAC inhibitors and selective HDAC6 inhibitors. We compared the pharmacological effects of the pan-HDAC inhibitor LBH589 (Panbinostat), the class I selective Romidepsin, and the selective HDAC6 inhibitors such as TubastatinA and NexturstatB, on two CTCL cell lines (HuT78, HuT102). Our findings thus far demonstrate the following: First, we observed a marked inhibition of proliferation capacity of both cell lines when treated with either pan-HDACi or the more selective HDAC6 inhibitors. However, the selective HDAC6 inhibitors showed less cytotoxicity. Second, we observed important changes in the expression of the co-inhibitory molecules, such as PD-L1. Given our results, we conclude that the selective targeting of HDAC6 could recapitulate the anti-tumor effects of pan-HDAC inhibitors without having the non-target cytotoxic effects often encountered when using pan-HDAC inhibitors. Disclosures No relevant conflicts of interest to declare.
Improved eigenvalue-based spectrum sensing via sensor signal overlapping (2016)

Eigenvalue-based detectors are considered as an important method of spectrum sensing since they do not require the information about the Primary User (PU)signal. In this paper we propose a method to improve the performance of the eigenvalue-based detector. In the proposed method, covariance matrix is calculated by a combinatorial matrix whose components are overlapping subgroups extracted from the array of received signals. As a result, covariance matrix with overlapping hasa larger maximum eigenvalue and trace value thanthe one without overlapping. Two near optimum detector, GLRT and RLRT are used to verify our method. Simulation results show that our proposed method can further improve the detection performance of these two detector. The paper also shows the effect of different overlapping methods on the receiver operating characteristic curve.
Metal–Organic Frameworks-Based Catalysts for Biomass Processing (2018)

Currently, metal–organic frame works (MOFs) as novel hybrid nanoporous materials are a top research interest, including endeavors in heterogeneous catalysis. MOF materials are promising heterogeneous catalytic systems due to their unique characteristics, such as a highly ordered structure, a record high surface area and a compositional diversity, which can be precisely tailored. Very recently, these metal-organic matrices have been proven as promising catalysts for biomass conversion into value-added products. The relevant publications show that the structure of MOFs can contribute essentially to the advanced catalytic performance in processes of biomass refining. This review aims at the consideration of the different ways for the rational design of MOF catalysts for biomass processing. The particular characteristics and peculiarities of the behavior of different MOF based catalytic systems including hybrid nanomaterials and composites will be also discussed by illustrating their outstanding performance with appropriate examples relevant to biomass catalytic processing.
Functional genomics and cancer drug target discovery. (2010)

The recent development of technologies for whole-genome sequencing, copy number analysis and expression profiling enables the generation of comprehensive descriptions of cancer genomes. However, although the structural analysis and expression profiling of tumors and cancer cell lines can allow the identification of candidate molecules that are altered in the malignant state, functional analyses are necessary to confirm such genes as oncogenes or tumor suppressors. Moreover, recent research suggests that tumor cells also depend on synthetic lethal targets, which are not mutated or amplified in cancer genomes; functional genomics screening can facilitate the discovery of such targets. This review provides an overview of the tools available for the study of functional genomics, and discusses recent research involving the use of these tools to identify potential novel drug targets in cancer.
Evolution of photonic metasurfaces: from static to dynamic (2016)

The realization of commercial photonic devices based on three-dimensional optical metamaterials is challenged by large absorptive losses as well as complex and costly fabrication. Metasurfaces—two-dimensional metamaterials—have been introduced to overcome these major challenges. They provide simple, compact, and power efficient solutions to problems of immense importance in photonics design. In addition to the strong potential of metasurfaces to enable next generation optical devices, their reduced dimensionality also allows for new physical effects which do not have volumetric counterparts. Furthermore, various technologies are presently emerging to provide modulation of metasurface response using mechanical, electrical, or optical control. Although the general purpose of these approaches is to obtain tunable versions of static metasurfaces, recent studies have uncovered that the impact of dynamic metasurfaces far exceeds tunability alone and comprises new physical effects such as Lorentz nonreciprocity. Here we start with reviewing recent developments of static metasurface devices and their applications. Then we discuss the burgeoning area of dynamic metasurfaces and demonstrate current evolving technologies to achieve time-varying properties and their conceivable applications.
Retzius-sparing robot-assisted radical prostatectomy is safe for patients with prior transurethral prostate surgery (2018)

Several studies have shown that patients with prior transurethral prostate surgery are associated with greater perioperative complications, as well as inferior oncological and functional outcomes when they undergo robot-assisted radical prostatectomy (RARP).
The C-terminal Tail of Presenilin Regulates Omi/HtrA2 Protease Activity (2004)

Presenilin mutations are responsible for most cases of autosomal dominant inherited forms of early onset Alzheimer disease. Presenilins play an important role in amyloid beta-precursor processing, NOTCH receptor signaling, and apoptosis. However, the molecular mechanisms by which presenilins regulate apoptosis are not fully understood. Here, we report that presenilin-1 (PS1) regulates the proteolytic activity of the serine protease Omi/HtrA2 through direct interaction with its regulatory PDZ domain. We show that a peptide corresponding to the cytoplasmic C-terminal tail of PS1 dramatically increases the proteolytic activity of Omi/HtrA2 toward the inhibitor of apoptosis proteins and beta-casein and induces cell death in an Omi/HtrA2-dependent manner. Consistent with these results, ectopic expression of full-length PS1, but not PS1 lacking the C-terminal PDZ binding motif, potentiated Omi/HtrA2-induced cell death. Our results suggest that the C terminus of PS1 is an activation peptide ligand for the PDZ domain of Omi/HtrA2 and may regulate the protease activity of Omi/HtrA2 after its release from the mitochondria during apoptosis. This mechanism of Omi/HtrA2 activation is similar to the mechanism of activation of the related bacterial DegS protease by the outer-membrane porins.
Cellular Mechanisms of Olfactory Signal Transduction (2005)

The sense of smell has the exquisite capacity to recognize and discriminate among an immense variety of volatile chemical compounds that are present in the environment. In mammals, olfactory cues are detected by sensory neurons belonging to three different sensory modalities harboured in the nasal cavity. Olfactory and vomeronasal primary sensory neurons (OSNs and VSNs, respectively) detect odorants and pheromones, whereas free nerve endings of the V cranial nerve (N. trigeminus) constitute the common chemical sense and convey pain, touch, temperature and chemosensory information. Our interest is to understand the molecular and cellular mechanisms of chemosensation in the diverse subsystems. A first common step in signal transduction is the specific binding of odorant molecules to receptor proteins located in specialized membrane protrusions: the cilia, microvilli or free nerve endings innervating the nasal mucosa. Olfactory and pheromone receptor proteins of OSNs and VSNs, respectively, are identified and functionally characterized to some extent. The intracellular mechanisms that transduce the initial chemical information into an electrical signal in OSNs involve the adenylate cyclase–cyclic nucleotide-gated channel pathway in addition to a recently identified phosphoinositides pathway. In contrast, a phospholipase C–diacylglycerol– transient receptor potential (TRP) channel pathway seems to play the major role in VSNs. However, the molecular mechanisms used by trigeminal neurons to detect odorant molecules are largely unknown. The beginning characterization of thermosensitive TRP channels among other receptors and ion channels expressed in trigeminal ganglion cells revealed their role in detection of chemical compounds and chemosensory signalling in these cells. The detection and interpretation of chemical cues in an animal’s