gebhart/patrepeval huggingface dataset:
The direction of landscape erosion (2022)

Abstract. The rate of erosion of a landscape depends largely on local gradient and material fluxes. Since both quantities are functions of the shape of the catchment surface, this dependence constitutes a mathematical straitjacket, in the sense that – subject to simplifying assumptions about the erosion process, and absent variations in external forcing and erodibility – the rate of change of surface geometry is solely a function of surface geometry. Here we demonstrate how to use this geometric self-constraint to convert a gradient-dependent erosion model into its equivalent Hamiltonian, and explore the implications of having a Hamiltonian description of the erosion process. To achieve this conversion, we recognize that the rate of erosion defines the velocity of surface motion in its orthogonal direction, and we express this rate in its reciprocal form as the surface-normal slowness. By rewriting surface tilt in terms of normal slowness components and deploying a substitution developed in geometric mechanics, we extract what is known as the fundamental metric function of the model phase space; its square is the Hamiltonian. Such a Hamiltonian provides several new ways to solve for the evolution of an erosion surface: here we use it to derive Hamilton's ray-tracing equations, which describe both the velocity of a surface point and the rate of change of the surface-normal slowness at that point. In this context, gradient-dependent erosion involves two distinct directions: (i) the surface-normal direction, which points subvertically downwards, and (ii) the erosion ray direction, which points upstream at a generally small angle to horizontal with a sign controlled by the scaling of erosion with slope. If the model erosion rate scales faster than linearly with gradient, the rays point obliquely upwards, but if erosion scales sublinearly with gradient, the rays point obliquely downwards. This dependence of erosional anisotropy on gradient scaling explains why, as previous studies have shown, model knickpoints behave in two distinct ways depending on the gradient exponent. Analysis of the Hamiltonian shows that the erosion rays carry boundary-condition information upstream, and that they are geodesics, meaning that surface evolution takes the path of least erosion time. Correspondingly, the time it takes for external changes to propagate into and change a landscape is set by the velocity of these rays. The Hamiltonian also reveals that gradient-dependent erosion surfaces have a critical tilt, given by a simple function of the gradient scaling exponent, at which ray-propagation behaviour changes. Channel profiles generated from the non-dimensionalized Hamiltonian have a shape entirely determined by the scaling exponents and by a dimensionless erosion rate expressed as the surface tilt at the downstream boundary.
Explosive detection using pixellated X-ray diffraction (PixD) (2013)

A novel, pixellated, energy-resolving X-ray detector has been utilised to simultaneously combine angular and energy dispersive X-ray diffraction (XRD). This approach allows a system to measure XRD data using the benefits of both approaches. Data acquisition is fast, and the system contains no moving parts, making it ideal for applications in security, particularly for the detection of explosive materials hidden within packages or baggage. Explosive samples supplied by the Centre for Applied Science and Technology, U.K. were examined using the pixellated diffraction technique, and the XRD data were compared with those from inert materials typically found inside luggage. A method of processing the data was developed, which greatly reduces the amount of data outputted from the detector whilst preserving the angular and energy resolution. Using principal component and discriminant analyses, a model was developed which predicts the correct classification of an unknown sample as either ``explosive'' or ``inert'' for data with acquisition times as low as one second.
Analysis of Underwater Acoustic Communication Channels (2013)

Abstract The underwater acoustic communication (UAC) channel presents many difficulties such as high frequency, space, and time selectivity, frequency-dependent noise, and significant range and band limitation on transmission. Traditional UAC channel models that model such channels primarily include environmental models based on experimental data; models that are developed using mathematical equations such as wave equations, modal methods, and parabolic equations; and using statistical distributions. These methods/models are often limited in their coverage and accurate representations of every possible UAC channel environment. It is also physically impractical and cost ineffective to try to measure/estimate each channel to determine its model. In this paper, the authors will present the analysis of UAC channels according to the UAC channel environments classified and presented in a prior work by the authors, in which cognitive intelligence is used in the selection of the appropriate channel representations according to each sensed environment. To the best knowledge of the authors, this type of analysis and representation of UAC channels with respect to each UAC environment has not been addressed in the literature to date and therefore presents a significant contribution.
Sex-dependent treatment of chronic EAE with partial MHC class II constructs (2017)

These findings will assist in the design of future clinical trials using pMHC for treatment of progressive MS.
Context-Sensitive Learning for Enhanced Audiovisual Emotion Classification (2012)

Human emotional expression tends to evolve in a structured manner in the sense that certain emotional evolution patterns, i.e., anger to anger, are more probable than others, e.g., anger to happiness. Furthermore, the perception of an emotional display can be affected by recent emotional displays. Therefore, the emotional content of past and future observations could offer relevant temporal context when classifying the emotional content of an observation. In this work, we focus on audio-visual recognition of the emotional content of improvised emotional interactions at the utterance level. We examine context-sensitive schemes for emotion recognition within a multimodal, hierarchical approach: bidirectional Long Short-Term Memory (BLSTM) neural networks, hierarchical Hidden Markov Model classifiers (HMMs), and hybrid HMM/BLSTM classifiers are considered for modeling emotion evolution within an utterance and between utterances over the course of a dialog. Overall, our experimental results indicate that incorporating long-term temporal context is beneficial for emotion recognition systems that encounter a variety of emotional manifestations. Context-sensitive approaches outperform those without context for classification tasks such as discrimination between valence levels or between clusters in the valence-activation space. The analysis of emotional transitions in our database sheds light into the flow of affective expressions, revealing potentially useful patterns.
A randomized phase 2 trial of idiotype vaccination and adoptive autologous T-cell transfer in patients with multiple myeloma (2021)

We hypothesized that combining adoptively transferred autologous T cells with a cancer vaccine strategy would enhance therapeutic efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-specific costimulated T cells. In this randomized phase 2 trial, patients received either control (KLH only) or Id-KLH vaccine, autologous transplantation, vaccine-specific costimulated T cells expanded ex vivo, and 2 booster doses of assigned vaccine. In 36 patients (KLH, n = 20; Id-KLH, n = 16), no dose-limiting toxicity was seen. At last evaluation, 6 (30%) and 8 patients (50%) had achieved complete remission in KLH-only and Id-KLH arms, respectively (P = .22), and no difference in 3-year progression-free survival was observed (59% and 56%, respectively; P = .32). In a 594 Nanostring nCounter gene panel analyzed for immune reconstitution (IR), compared with patients receiving KLH only, there was a greater change in IR genes in T cells in those receiving Id-KLH relative to baseline. Specifically, upregulation of genes associated with activation, effector function induction, and memory CD8+ T-cell generation after Id-KLH but not after KLH control vaccination was observed. Similarly, in responding patients across both arms, upregulation of genes associated with T-cell activation was seen. At baseline, all patients had greater expression of CD8+ T-cell exhaustion markers. These changes were associated with functional Id-specific immune responses in a subset of patients receiving Id-KLH. In conclusion, in this combination immunotherapy approach, we observed significantly more robust IR in CD4+ and CD8+ T cells in the Id-KLH arm, supporting further investigation of vaccine and adoptive immunotherapy strategies. This trial was registered at www.clinicaltrials.gov as #NCT01426828.
Preclinical Results of the Camptothecin-Polymer Conjugate IT-101 in Multiple Human Lymphoma Xenografts. (2007)

Abstract Camptothecin (CPT), a natural alkaloid isolated from Camptotheca acuminata, has potent broad spectrum antitumor activity by inhibiting type I DNA topoisomerase. It has not been used clinically because it is water-insoluble and highly toxic. As a result, irinotecan (CPT-11), a water-soluble analogue of CPT, has been developed and used as salvage chemotherapy in patients with refractory/relapsed lymphoma, but with only modest activity. For intravenous administration, we have developed IT-101, a ca. 40 nm diameter nanoparticle that is an assembly of cyclodextrin-based polymer conjugates of 20-(S)-CPT. The purpose of this study is to compare the preclinical efficacy of IT-101 with CPT-11 both in vitro and in vivo. Fluorescence microscopy studies demonstrated that incubation of a human lymphoma cell line with IT-101 resulted in the uptake and intracellular accumulation of CPT. Based on the demonstration of in vitro cytotoxity of IT-101 against multiple human lymphoma cell lines, we initiated experiments in xenograft models of lymphoma. In subcutaneous human xenograft models, a single cycle of three weekly doses of intravenous IT-101 at 10 mg/kg (CPT equivalents) showed significantly potent antitumor activity against Daudi, Karpas 299, and L540 cell lines compared to three weekly doses of intraperitoneal CPT-11 at its maximum tolerated dose in mouse of 100 mg/kg (P &lt; 0.0001, P = 0.0072, and P &lt; 0.0001, respectively). In the same animal models, IT-101 led to pathologically complete remissions in 78%, 44%, and 78% of animals inoculated with Daudi, Karpas 299, and L540 cell lines, respectively. In disseminated human xenograft models, IT-101, administered using the same dosing schedule, significantly prolonged the survival of animals intravenously injected with either Daudi or Karpas 299 cell lines when compared to CPT-11 (P &lt; 0.0001 and P = 0.0049, respectively). The promising present results in a variety of lymphomas provide the basis for a phase I/II clinical trial in patients with refractory/relapsed lymphoma.
Optical Field Concentration in Low-Index Waveguides (2006)

We present a highly efficient optical field concentrator that is capable of confining optical field in nanometer-thin low-index media with very high optical confinement factor. The structure is made of multiple-layered low-index nanolayers embedded in high-index silicon waveguides. By creating multiple high-index-contrast interfaces, the normal field in the low-index nanolayer regions is significantly enhanced. It subsequently results in a very high optical confinement and power density in these regions. With the help of numerical simulation tools, the guiding and propagating characteristics of the new structure are studied and presented. The optimal structures have demonstrated confinement factors and normalized power densities in the range of 30%-60% and 20-160 /spl mu/m/sup -2/ for the 5-20-nm thin low-index multiple nanolayers.
Can tourism be considered an instrument of European integration? (2022)

A historical overview of European tourism will also be the opportunity to consider how tourism as a mode of movement is rooted within Europe while at the same time continuing to construct that space. The study of tourism from the perspective of visitor flows reveals the scale of the importance the activity has taken on in the lives of Europeans. The mountains of the Alps were European tourist attractions, and the shores of the Mediterranean saw the emergence of ‘winter towns’ in France, Italy and Greece. The importance of tourism-generated economic flows is apparent in the observation that over one in ten European companies were part of the tourism industry in 2018. The COVID-19 crisis profoundly impacted the tourism industry, with activity slumping by over 80%. Tourism companies also help, in their own way, to support European integration. Tourism’s multiple facets allow us to approach the notion of European integration through a great diversity of perspectives.
Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters (2015)

Studies have shown that exposure to chronic mild stress decreases ethanol intake and preference in dopamine D2 receptor wild-type mice (Drd2 (+/+)), while it increases intake in heterozygous (Drd2 (+/-)) and knockout (Drd2 (-/-)) mice. Dopaminergic neurotransmission in the basal forebrain plays a major role in the reinforcing actions of ethanol as well as in brain responses to stress. In order to identify neurochemical changes associated with the regulation of ethanol intake, we used in vitro receptor autoradiography to measure the levels and distribution of dopamine D1 and D2 receptors and dopamine transporters (DAT). Receptor levels were measured in the basal forebrain of Drd2 (+/+), Drd2 (+/-), and Drd2 (-/-) mice belonging to one of four groups: control (C), ethanol intake (E), chronic mild stress exposure (S), and ethanol intake under chronic mild stress (ES). D2 receptor levels were higher in the lateral and medial striatum of Drd2 (+/+) ES mice, compared with Drd2 (+/+) E mice. Ethanol intake in Drd2 (+/+) mice was negatively correlated with striatal D2 receptor levels. D2 receptor levels in Drd2(+/-) mice were the same among the four treatment groups. DAT levels were lower in Drd2(+/-) C and Drd2 (-/-) C mice, compared with Drd2 (+/+) C mice. Among Drd2(+/-) mice, S and ES groups had higher DAT levels compared with C and E groups in most regions examined. In Drd2(-/-) mice, ethanol intake was positively correlated with DAT levels in all regions studied. D1 receptor levels were lower in Drd2(+/-) and Drd2(-/-) mice, compared with Drd2(+/+), in all regions examined and remained unaffected by all treatments. The results suggest that in normal mice, ethanol intake is associated with D2 receptor-mediated neurotransmission, which exerts a protective effect against ethanol overconsumption under stress. In mice with low Drd2 expression, where DRD2 levels are not further modulated, ethanol intake is associated with DAT function which is upregulated under stress leading to ethanol overconsumption.
A Promising Physical Pest-Control System Demonstrated in a Greenhouse Equipped With Simple Electrostatic Devices That Excluded All Insect Pests: A Review (2019)

Applied electrostatic engineering can be used to construct greenhouses that prevent entry of insect pests. Two types of electric field screen were used to exclude pests from the greenhouse: single- and double-charged dipolar electric field screens (S- and D-screen, respectively). The S-screen consisted of iron insulated conductor wires (ICWs) arrayed in parallel (ICW-layer), a grounded metal net on either side of the ICW-layer, and a direct current voltage generator. S-screens were attached to the side windows of the greenhouse to repel whiteflies (Bemisia tabaci) that approached the nets. The D-screen was installed in a small anteroom at the greenhouse entrance to capture whiteflies entering through it. The ICW-layers of the D-screen were oppositely charged with equal voltages and arrayed alternately, and an insulator board or grounded metal net was placed on one side of the ICW-layer. The ICW-layers captured whiteflies entering the electric field of the double-charged dipolar electric field. Three screens equipped with yellow or gray boards or a grounded metal net were installed in the anteroom based on the airflow inside the room, as most whiteflies were brought in by air when the door was opened. Two D-screens with boards were useful for directing the airflow toward the wall with the netted D-screen. This screen eliminated the insects and the pest-free air was circulated inside the greenhouse. The D-screen with the yellow board attracted the whiteflies and was effective for trapping them when there was no wind. Our method kept the greenhouse pest-free throughout the entire period of tomato (Solanum lycopersicum) cultivation.
Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2 (2010)

Recent work has led to the identification of novel endocytic compartments with functional roles in both protein trafficking and growth factor signal transduction. The phosphatidylinositol 3-phosphate binding, FYVE domain-containing protein WDFY2 is localized to a distinct subset of early endosomes, which are localized close to the plasma membrane. Here, we find that the serine/threonine kinase Akt interacts with these endosomes in an isoform-specific manner. Using quantitative fluorescence microscopy we demonstrate specific co-localization of WDFY2 with endogenous Akt2, but not Akt1. Moreover, depletion of WDFY2 leads to impaired phosphorylation of Akt in response to insulin due to isoform specific reduction of Akt2, but not Akt1, protein levels, and to a marked reduction in the insulin-stimulated phosphorylation of numerous Akt substrates. This is accompanied by an impairment in insulin-stimulated glucose transport and, after prolonged silencing, a reduction in the level of expression of adipogenic genes. We propose that WDFY2-enriched endosomes serve as a scaffold that enables specificity of insulin signaling through Akt2.
Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid This work was supported by the National Institutes of Health (Grant Numbers: CA28824). Postdoctoral Fellowship support is gratefully acknowledged by M.W.C. (U.S. Army BCRP, DAMD17-98-1-8154), M.F.H. (5T32 CA62948-05), and D.T. (Schering Research Foundation, Berlin). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses. (2001)

Important intermediates: in an effort to synthesize and determine the stereochemistry of pinnaic acid, C14-epimeric aldehydes 1 and 2 were generated from Meyers' lactam 3. A key step in the parallel syntheses is a highly stereoselective vinylogous Michael cyclization; Boc = tert-butoxy carbonyl, TFA = trifluoroacetic acid.
Aerobic Mineralization of Hexachlorobenzene by Newly Isolated Pentachloronitrobenzene-Degrading Nocardioides sp. Strain PD653 (2009)

A novel aerobic pentachloronitrobenzene-degrading bacterium, Nocardioides sp. strain PD653, was isolated from an enrichment culture in a soil-charcoal perfusion system. The bacterium also degraded hexachlorobenzene, a highly recalcitrant environmental pollutant, accompanying the generation of chloride ions. Liberation of (14)CO(2) from [U-ring-(14)C]hexachlorobenzene was detected in a culture of the bacterium and indicates that strain PD653 is able to mineralize hexachlorobenzene under aerobic conditions. The metabolic pathway of hexachlorobenzene is initiated by oxidative dechlorination to produce pentachlorophenol. As further intermediate metabolites, tetrachlorohydroquinone and 2,6-dichlorohydroquinone have been detected. Strain PD653 is the first naturally occurring aerobic bacteria capable of mineralizing hexachlorobenzene.
Flaw detection in solid with the D.O.R.T. method (2002)

The D.O.R.T, method (Decomposition de l'Operateur de Retournement Temporel) is a scattering analysis technique using large arrays of transducers. The effectiveness of the method to detect and focus selectively on scatterers was presented in "C.Prada et al., J. Acoust. Soc. Am. 99 (4) 2067-76 (1996)." Here, the method is arrays of transducers. The inter element impulse responses from the transmit to the receive array are measured. It is shown how the singular value decomposition of the corresponding transfer matrix allows to separate the different components of the scattered field. The method is applied to the detection and separation of flaws in a solid sample. The problem of optimisation of the transmit array in order to reduce the signal to noise ratio and to lower the data size is considered.
The Epidermal Growth Factor Receptor Family of Tyrosine Kinases and Cancer: Can An Atypical Exemplar Be A Sound Therapeutic Target? (1996)

Abstract: Epidermal Growth Factor (EGF) receptor was the first peptide growth hormone receptor found to contain an intracellular tyrosine kinase. It is frequently used to exemplify the properties of the whole family of receptor tyrosine kinases. Much work has been done on EGFr to elucidate the mechanisms of activation of RTKs, and their coupling to downstream signaling processes. The type I RTKs consist of four closely related RTKs, and a bewildering number of ligands. The number of ligands is not typical for RTKs, but the discovery that this family can form signaling-competent heterodimers as well as homodimers may explain this abundance. The type I RTKs are almost ubiquitous in solid neoplasias, as 90% of clinical samples express at least one family member, and at least 60% of tumours overexpress at least one of the receptors or cognate growth factors. Overexpression correlates with poor prognosis and shorter survival times. The high prevalence suggests that type I RTKs may activate more transforming signaling pathways that most other RTKs. Both the high prevalence, and the importance of the EGFr family to the transformed phenotype, suggest that inhibition of their signaling will have therapeutic utility. This has been investigated by finding blocking antibodies for the ligand binding domains of the receptors, enzyme inhibitors for the tyrosine kinases of the family and inhibitors of downstream signaling. The enzyme inhibitor approach has led to small molecule enzyme inhibitors of great potency and selectivity for the EGFr tyrosine kinase.
The Living Museum of Iron and Steel Technology (1998)

THE best way to understand the “nested problems” dynamic and related dilemmas of SOE restructuring is to delve into the operations of the individual firm. This chapter will do that by focusing upon the Anshan Iron and Steel Company, a 220,000-employee integrated steel operation based in Liaoning Province, the heart of China's Manchurian “rust belt.”
Chromium(VI)-induced damage to the cytoskeleton and cell death in isolated hepatocytes (2002)

Cr(VI) is a known human carcinogen. Although it has been investigated widely, the mechanism(s) of its action is/are not fully understood. The aim of this study was to evaluate Cr(VI)-induced damage to the cell cytoskeleton and the mode of cell death in primary cultures of hepatocytes. Exposure of the cultured cells (10(5)/cm(2)) to 1 and 5 microM Cr(VI) for 24 h resulted in loss of the cell cytoskeleton, and this was accompanied by membrane blebbing and shrinking of the cell. Staining of the cells with annexin V and propidium iodide showed that Cr(VI) induces apoptosis at low concentrations (5 microM), whereas at higher concentrations (25 microM) it induces necrosis. This study shows that Cr(VI) causes damage to the cell cytoskeleton, and induces apoptosis at low concentrations. However, the importance of necrosis and apoptosis in vivo, and the effects of longer exposure times, which simulate environmental and occupational exposure to Cr(VI), remain to be investigated.