gebhart/patrepeval huggingface dataset:
Clock jitter correction circuit for high speed clock signals using delay units a nd time selection window (2016)

In this paper, a clock jitter correction circuit is proposed. The circuit corrects the jitter error in the location of the rising and falling edges of the clock pulses. The circuit topology employs delay units and time selection window to ensure jitter free output. The number of the corrected edges of the clock signal is equal to the number of edge correction units.
Ring Opening of Naphthene Hydrocarbons under Conditions of Thermal and Microwave Heating (2018)

A comparative study of the activity and selectivity of monometallic Ir-containing catalysts in ring opening reactions under conditions of thermal and microwave heating is performed using the example of cyclohexane. The hydrogenolysis of cyclohexane is shown to be possible with microwave activation. It is found that upon microwave heating, iridium-containing catalysts supported on titanium oxide and activated carbon allow 60% selectivity to be reached with respect to ring opening products at 30% conversion of the initial cyclohexane.
Abstract 4453: Molecular hallmarks of drug resistance to DNA methylation inhibitors and alternative therapeutic regimen for overcoming resistance (2016)

Abstract Aberrant DNA methylation perturbing the epigenetic machinery has been continuously underlined as the major hallmark involved in all types of cancer. The archetypal DNA methylation inhibitor, 2’-deoxy-5-azacytidine (5-AZA-CdR) have been approved by FDA as the effective epigenetic drug for the treatment of blood malignancies, over a decade. However, the successful epigenetic therapy remains impeded owing to its chemotherapeutic resistance. To investigate the molecular mechanism of resistance to 5-AZA-CdR, we developed several HCT116 p53 wild-type cell clones, resistant towards 5-AZA-CdR, and principally studied the molecular alterations during the development of resistance, using high throughput RNA sequencing based transcriptomics and mass spectrometry based proteomics. The molecular profiling of HCT116 cells sensitive to 5-AZA-CdR treatment versus 5-AZA-CdR resistant cell clones distinguished the differential expression of various genes and the proteins coded by the genes, compared with untreated HCT116 wild-type cells (ANOVA p&amp;lt;0.05). The major affected cellular pathways were (i) Cell cycle: role of 14-3-3 proteins in cell cycle regulation, G1/S transition and initiation of mitosis (ii) Apoptosis and survival: granzyme A signaling, BAD phosphorylation, p53 dependent apoptosis (iii) Transcription: role of heterochromatin protein I family in transcriptional silencing, role of AP1 in regulation of cellular metabolism (iv) DNA damage: role of SUMO in p53 regulation. Further, we used MTT cytotoxicity assay to determine the cross-resistance or sensitivity of the 5-AZA-CdR resistant cell clones towards the inhibitors of epigenetic “Readers-Writers-Erasers”. The study revealed that 5-AZA-CdR resistant cell clones exhibited cross-resistance towards all the tested epigenetic inhibitors, however, significant sensitivity was exceptionally observed for bromodomain inhibitors. Additionally, the well-known bromodomain inhibitor, (+)-JQ1, showed significant anti-tumor activity sensitizing 5-AZA-CdR resistant HCT116 xenografts, suggesting bromodomain inhibition as the alternative therapeutic regimen for overcoming resistance to DNA methylation inhibitors. Validation of relevant genes and/or proteins as biomarkers for predicting clinical response to 5-AZA-CdR, including mutation analysis and methylome sequencing, and studies validating bromodomains as alternative therapeutic target for re-sensitizing the cancer patients, resistant to DNA methylation inhibitors is currently ongoing. Citation Format: Khushboo Agrawal, Petr Vojta, Dusan Holub, Rastislav Slavkovsky, Ivo Frydrych, Petr Dzubak, Marcela Krecmerova, Marian Hajduch. Molecular hallmarks of drug resistance to DNA methylation inhibitors and alternative therapeutic regimen for overcoming resistance. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4453.
20 Endothelial loss as a cause of impaired myocardial perfusion reserve on CMR in severe aortic stenosis (2019)

<h3>Background</h3> Impaired myocardial perfusion reserve occurs in pressure overload hypertrophy such as in severe aortic stenosis (AS) despite unobstructed epicardial coronaries. However the pathological mechanisms underlying this are poorly understood. We sought to assess myocardial perfusion reserve in severe AS by stress perfusion cardiovascular magnetic resonance (CMR), and examine the findings in relation to the histological evidence of vascular changes in the myocardium. <h3>Methods</h3> Fourteen patients with severe AS and unobstructed epicardial coronaries underwent adenosine stress perfusion CMR before and 6 months after surgical aortic valve replacement (AVR). Myocardial biopsies were obtained during AVR and stained using CD31 +for endothelium, smooth muscle actin (SMA) for smooth muscle, and picrosirius red for fibrosis. Nine age- and sex- matched post-mortem myocardial samples served as histological controls. <h3>Results</h3> When compared to controls, the myocardium of patients with severe AS had reduced vessel density, total quantity of SMA +ve and CD31 +ve, in addition to the expected increase in fibrosis. There was absence of CD31 +ve endothelium in SMA +ve arterioles, indicating endothelial loss. (Figure 1) Importantly, patients with an aortic valve area (AVA) ≤0.8cm<sup>2</sup> had greater endothelial loss compared to those with an AVA &gt;0.8 and≤1.0cm<sup>2</sup> (1.34%±0.44% vs 2.84±1.03%, p=0.006), and endothelial loss also correlated with myocardial perfusion reserve index (MPRI), r=0.66, p=0.019. MPRI improved significantly post AVR (from 0.95±0.17 to 1.50±0.43, p=0.018). <h3>Conclusion</h3> In severe AS, there is microvascular rarefaction and loss of endothelium, which is more pronounced in patients with the most severe aortic valve narrowing. This appears to be an underlying mechanism for reduced myocardial perfusion reserve, which may be reversible post AVR.
Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase (1995)

The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs its cellular trafficking and negatively regulates its kinase activity. Here we report that the serine/threonine phosphatase inhibitor, okadaic acid, destabilized the heat-shock protein 90-pp60v-src chaperone complex in v-src-transfected cells. Concomitant with complex destabilization by okadaic acid, phosphoserine was doubled and phosphothreonine was increased 20-fold in the heat-shock protein 90. Although phosphorylation of the total pool of immunoprecipitable pp60v-src was unchanged, okadaic acid slightly increased phosphoserine and phosphothreonine levels specifically in pp60v-src bound to heat-shock protein 90. The low level of tyrosine phosphorylation in the pp60v-src complexed with heat-shock protein 90 was further decreased by okadaic acid. Interestingly, okadaic acid-stabilized hyperphosphorylation of the heat-shock protein 90-pp60v-src complex lowered the level of pp60v-src in cell membranes, the functional location for pp60v-src. We suggest that serine/threonine phosphorylation of heat-shock protein 90 and/or pp60v-src functions as a regulatory molecular trigger to release pp60v-src from the chaperone complex at the inner surface of cell membranes.
ChemInform Abstract: The Chemistry of TTFTT; Part 1: New Efficient Synthesis and Reactions of Tetrathiafulvalene‐2,3,6,7‐tetrathiolate (TTFTT): An Important Building Block in TTF‐Syntheses. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Specific transcellular binding between membrane proteins crucial to Alzheimer disease. (1996)

Molecular genetic studies of families suffering from genetic forms of early onset Alzheimer disease (AD) have identified three genes and their protein products as being crucially involved in the etiology of AD. The three proteins are all integral membrane proteins. One of them is beta-APP, the precursor of the beta-amyloid found in the characteristic neuritic plaques present in the brains of AD patients. The other two, S182 and STM2, are homologous in amino acid sequence to one another but are unrelated to beta-APP. It is shown here, using cultured cells transfected for each of these proteins, that beta-APP binds specifically and transcellularly to either S182 or STM2. We propose that this transcellular binding may not only be important in normal neuronal physiology and development but may be directly involved in the process of formation of beta-amyloid from beta-APP.
Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides (2021)

We previously reported that IF7 peptide, which binds to the annexin A1 (ANXA1) N-terminus, functions as a tumor vasculature-targeted drug delivery vehicle after intravenous injection. To enhance IF7 stability in vivo , we undertook mirror-image peptide phage display using a synthetic D-peptide representing the ANXA1 N-terminus as target. We then identified peptide sequences, synthesized them as D-amino acids, and designated the resulting peptide dTIT7, which we showed bound to the ANXA1 N-terminus. Whole body imaging of mouse brain tumor models injected with near infrared fluorescent IRDye-conjugated dTIT7 showed fluorescent signals in brain and kidney. Furthermore, orally-administered dTIT7/geldanamycin (GA) conjugates suppressed brain tumor growth. Ours is a proof-of-concept experiment showing that ANXA1-binding D-peptide can be developed as an orally-administrable tumor vasculature-targeted therapeutic.
Alpha particle effects on bipolar ECL static arrays (1985)

This paper will discuss results obtained between experimental studies and circuit simulation of the soft error rates versus critical charge in static bipolar ECL memory arrays. Design optimization and process innovation was used to achieve failure rates below 0.1 fails/bit/Khr with critical charge exceeding 300fC.
Saving energy with just in time instruction delivery (2002)

Just-In-Time instruction delivery is a general method for saving energy in a microprocessor by dynamically limiting the number of in-flight instructions. The goal is to save energy by 1) fetching valid instructions no sooner than necessary, avoiding cycles stalled in the pipeline -- especially the issue queue, and 2) reducing the number of fetches and subsequent processing of mis-speculated instructions. A simple algorithm monitors performance and adjusts the maximum number of in-flight instructions at fairly long intervals, 100K instructions in this study. The proposed JIT instruction delivery scheme provides the combined benefits of more targeted schemes proposed previously. With only a 3% performance degradation, energy savings in the fetch, decode pipe, and issue queue are 10%, 12%, and 40%, respectively.
Design Optimization of a Linear-Motion Large-Displacement Micro Mechanism for High Off-Axis Stiffness (2009)

This paper presents research on the large-displacement linear-motion planar compliant mechanism (X-Bob) specific to MEMS applications. The X-Bob’s potential for high off-axis stiffness makes it a strong candidate for precision MEMs applications. Understanding the characteristics and performance of the X-Bob can lead to the ability to modify it to fit specific applications. In this work, an X-Bob design is optimized for increased off-axis stiffness while maintaining a small footprint. The results are compared to previous X-Bob designs and to folded beam suspensions. Advantages and disadvantages of each design are explained.
Cytosolic Phospholipase A 2 Enzymes Are Not Required by Mouse Bone Marrow-Derived Macrophages for the Control of Mycobacterium tuberculosis In Vitro (2006)

During the course of infection Mycobacterium tuberculosis predominantly resides within macrophages, where it encounters and is often able to resist the antibacterial mechanisms of the host. In this study, we assessed the role of macrophage phospholipases A2 (PLA2s) in defense against M. tuberculosis. Mouse bone marrow-derived macrophages (BMDMs) expressed cPLA2-IVA, cPLA2-IVB, iPLA2-VI, sPLA2-IIE, and sPLA2-XIIA. The expression of cPLA2-IVA was increased in response to M. tuberculosis, gamma interferon, or their combination, and cPLA2-IVA mediated the release of arachidonic acid, which was stimulated by M. tuberculosis in activated, but not unactivated, macrophages. We confirmed that arachidonic acid is highly mycobactericidal in a concentration- and pH-dependent manner in vitro. However, when M. tuberculosis-infected macrophages were treated with PLA2 inhibitors, intracellular survival of M. tuberculosis was not affected, even in inducible nitric oxide synthase-deficient macrophages, in which a major bactericidal mechanism is removed. Moreover, intracellular survival of M. tuberculosis was similar in cPLA2-IVA-deficient and wild-type macrophages. Our results demonstrate that the cytosolic PLA2s are not required by murine BMDMs to kill M. tuberculosis.
Role of Anomalous Channeling on HAADF in a Quasi-ID KMn6Bis Structure (2018)

One-dimensional (1D) structures reveal unconventional properties such as topological spin excitation [1], Luttinger liquid with spin-charge separation Because the perfect 1D structure is rare in nature and observation along the 1D chain direction is problematic using TEM, quasi-one-dimensional (Q1D) compounds with atomic or molecular chains bundled into two-dimension (2D) KMn6Bi5 is a Q1D structure, a unique 2D array of one-dimensional [Mn6Bi5] nanowire (NW) along the b axis shown in Fig. and = 124.578. Each [Mn6Bi5] NW (diameter8.7 ) is composed of a Bi nanotube (NT) shell surrounding a Mn nanorod (NR) core. While the Bi NT consists of Bi pentagons stacked along b axis, the Mn NR consists of outer Mn pentagon caging a 1D Mn atomic straight chain at center along the b axis. Because 21 screw axis is located on the center 1D Mn, the atomic density of the center Mn column have effectively two times higher than that of outer Bi and Mn atomic columns as shown in Fig. The HAADF contrast provides interpretable Z-contrast collecting incoherently high-scattered elastic electrons. However, electron channeling (EC) on uniquely isolated one-dimensional (1D) atomic column acting as 1D electron waveguide can disturb straightforward interpretation of experimental Z-dependent HAADF contrast.
In situ observation of solid electrolyte interphase evolution in a lithium metal battery (2019)

Abstract Lithium metal is a favorable anode material in all-solid Li-polymer batteries because of its high energy density. However, dendrite formation on lithium metal causes safety concerns. Here we obtain images of the Li-metal anode surface during cycling using in situ scanning electron microscopy. Constructing videos from the images enables us to monitor the failure mechanism of the battery. Our results show the formation of dendrites on the edge of the anode and isles of decomposed lithium bis(trifluoromethanesulfonyl)imide on the grain boundaries. Cycling at high rates results in the opening of the grain boundaries and depletion of lithium in the vicinity of the isles. We also observe changes in the surface morphology of the polymer close to the anode edge. Extrusion of lithium from these regions could be evidence of polymer reduction due to a local increase in temperature and thermal runaway assisting in dendrite formation.
Prediction of harmonic power losses in fuses located in DC-link circuit of an inverter (2003)

Fuses may in the future enter into the DC link of voltage-source converters and the harmonic power losses prediction in fuses is very important for the manufacturers in order to predict lifetime and protection level of the converter. The DC-link current has a high harmonic content for an inverter that uses any kind of space-vector modulation strategy. The aim of this paper is to find a useful approximation for the AC resistance of a fuse and to predict the harmonic power losses in it when it is fed from an inverter.
A simple percutaneous technique for hemostasis and closure after transcatheter aortic valve implantation (2011)

Access closure is a key element to successful retrograde percutaneous transfemoral transcatheter aortic valve implantation. It requires large-bore femoral arterial access (18Fr-28Fr) which most operators manage with surgical access and closure under general anesthesia. We report a case example of how, using our center's peripheral interventional experience, we have developed a simple five step technique to achieve hemostasis percutaneously.
Modeling of an original curved waveguide for microwave filtering applications (2002)

Characterization, parameters analysis and modeling of waveguides devices are three closely related processes presented here over different strategies to provide the results for a microwave filter circuit. The PVM techniques are also used in order to improve the number of simulations necessary for the characterization of the filter device. The expected results of simulation for a four poles Chebyshev filter is obtained. Trends in this kind of association is also discussed generally in this paper.
Long-Horizon Motion Planning via Sampling and Segmented Trajectory Optimization (2022)

This paper presents a hybrid robot motion planner that generates long-horizon motion plans for robot navigation in environments with obstacles. We propose a hybrid planner, RRT* with segmented trajectory optimization (RRT*-sOpt), which combines the merits of sampling-based planning, optimization-based planning, and trajectory splitting to quickly plan for a collision-free and dynamically-feasible motion plan. When generating a plan, the RRT* layer quickly samples a semi-optimal path and sets it as an initial reference path. Then, the sOpt layer splits the reference path and performs optimization on each segment. It then splits the new trajectory again and repeats the process until the whole trajectory converges. We also propose to reduce the number of segments before convergence with the aim of further reducing computation time. Simulation results show that RRT*-sOpt benefits from the hybrid structure with trajectory splitting and performs robustly in various robot platforms and scenarios.
Ribotype diversity of Listeria monocytogenes strains associated with outbreaks of listeriosis in ruminants (1996)

Ribotyping is a molecular method for the characterization, identification, and typing of bacterial isolates that has value in epidemiological studies. To demonstrate the utility of this technique for typing of Listeria monocytogenes, four outbreaks of epizootic listeriosis in ruminants were investigated through coordinated detection and characterization methods utilizing classical microbiology and nucleic acid-based techniques. L. monocytogenes strains isolated from clinical samples and the silage consumed by the affected animals were ribotyped to establish the causal relationship between feed and the disease outbreak. For all but one outbreak, we were able to isolate L. monocytogenes strains represented by the same ribotype from both clinical and silage samples. Additional L. monocytogenes strains with ribotypes different from those of the respective clinical samples were isolated from all silage samples. This indicates that a diverse population of L. monocytogenes strains exists in farm environments, of which some may be more likely than others to cause disease.
Interpretation of a spin-tickling experiment on (Monohaptocyclopentadienyl)- (methyl)(dichloro)silane (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterpretation of a spin-tickling experiment on (Monohaptocyclopentadienyl)- (methyl)(dichloro)silaneF. Albert Cotton and Tobin J. MarksCite this: Inorg. Chem. 1970, 9, 12, 2802–2804Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/ic50094a043https://doi.org/10.1021/ic50094a043research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Central Bright Spot Sign: A Potential New MR Imaging Sign for the Early Diagnosis of Anterior Ischemic Optic Neuropathy due to Giant Cell Arteritis (2017)

Here, we provide evidence of a new MR imaging sign that identifies the acute stage of giant cell arteritis-related anterior ischemic optic neuropathy; patients without this central bright spot sign always had a nonarteritic pathophysiology and therefore did not require emergency corticosteroid therapy.
Enhanced Interference Cancellation of Cell-Specific Reference Signals for LTE-A (2015)

The performance of the physical downlink shared channel (PDSCH) of Long-Term Evolution Advanced (LTE-A) carrying downlink data traffic to the users served in a cell is typically limited by co channel interference from neighboring cells. One of the most significant interference sources in LTE/LTE-A is cell-specific reference signals (CRS), which are transmitted by neighboring cells across the entire frequency band even when downlink data traffic is not present. As a consequence, in scenarios without PDSCH from neighboring cells, CRS interference becomes the limiting factor in achieving higher downlink throughput. Therefore, interference cancellation from CRS becomes one of the important signal processing problems in LTE/LTE A systems. In conventional receivers, CRS interference is canceled by using channel estimates corresponding to neighboring cells, which are obtained from the received signal. However, the presence of the useful signal transmitted by the serving cell in the received signal makes channel estimation for neighboring cell CRS less accurate. As a result, the performance of such CRS interference cancellation (CRS IC) receivers is typically poor in medium and high signal to interference ratio (SIR) scenarios. In this paper, we propose a novel decoding aided CRS-IC receiver for LTE A systems. The key idea of the proposed scheme is to generate a soft estimate of the useful signal using the turbo decoding scheme and cancel this from the total received signal prior to the estimation of the channels corresponding to interfering cells. Compared to conventional schemes considered in 3GPP until now, the proposed approach provides performance improvements in a wider range of SIRs, while the performance approaches the one of an ideal system using perfect cancellation of CRS interference from neighboring cells.