gebhart/patrepeval huggingface dataset:
Laser damage threshold and microfaultness of large KDP crystals (1998)

The faulty microstructure of KDP samples having different bulk laser damage threshold (4 multiplied by 1010 W/cm2 - 5.4 multiplied by 1011 W/cm2 was studied using the methods of the three-crystal x-ray diffraction and two-crystal topography on reflection. A correlation between the dispersion of the structure-sensitive parameters characterizing the microfaultness and the value of bulk laser threshold of samples cut off large KDP crystals was established.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Noninvasive multianalyte diagnostic assay for monitoring bladder cancer recurrence (2012)

The urine-based multianalyte diagnostic readout assay was able to delineate the patient population into those highly likely to have bladder cancer recurrence, those unlikely to have recurrent disease, and those with an average risk for bladder cancer recurrence.
The role of immunoproteasomes in antigen presentation and thymic selection (100.7) (2011)

Abstract Proteasomes, multisubunit complexes that degrade cellular proteins, are instrumental in forming epitopes for MHC class I antigen presentation. An alternate set of catalytic proteasome beta subunits are induced by IFN-gamma and expressed constitutively in dendritic cells, T-cells and B-cells. Immunoproteasomes containing these inducible subunits have increased chymotryptic and tryptic activities and decreased caspase-like activity, and are hypothesized to produce more peptides suitable for binding to MHC class I. To date mutant mice lacking one or two of the immunoproteasome subunits have been generated and have revealed some changes in MHC class I antigen presentation. However, the overall role of the immunoproteasome is unclear because mice that completely lack all three subunits have not been produced up until now. We have generated mice that completely lack immunoproteasomes. These animals have reduced presentation of MHC class I-presented peptides, and the peptides that are presented appear to be substantially different than those on cells from wild type mice. Moreover, the phenotype of these animals is distinct from mice lacking any individual immunoproteasome subunit. The loss of immunoproteasomes also affects T cell development in the thymus. The phenotype of these animals will be discussed.
ChemInform Abstract: Solution‐Phase Parallel Synthesis of Benzoxazines Using a Polymer‐Supported Carbodiimide. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optical Coupling between Antibonding Film Plasmon Modes and Perpendicularly Polarized Light (2009)

We demonstrate the spectral properties of resonant transmission induced by perpendicularly polarized light through an individual hole in a thin metallic film, using time-domain terahertz spectroscopy. Our measurements and intuitive understanding show that the resonance is activated by a coupling between the perpendicular component of incident light and existing antibonding film plasmon modes.
Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior (2021)

Systemic administration of ML297, a selective activator of G-protein-gated inwardly rectifying K<sup>+</sup> (GIRK) channels, decreases innate avoidance behavior in male C57BL/6J mice. The cellular mechanisms mediating the ML297-induced suppression of avoidance behavior are unknown. Here, we show that systemic ML297 administration suppresses elevated plus maze (EPM)-induced neuronal activation in the ventral hippocampus (vHPC) and basolateral amygdala (BLA) and that ML297 activates GIRK1-containing GIRK channels in these limbic structures. While intracranial infusion of ML297 into the vHPC suppressed avoidance behavior in the EPM test, mirroring the effect of systemic ML297, intra-BLA administration of ML297 provoked the opposite effect. Using neuron-specific viral genetic and chemogenetic approaches, we found that the combined inhibition of excitatory neurons in CA3 and dentate gyrus (DG) subregions of the vHPC was sufficient to decrease innate avoidance behavior in the EPM, open-field, and light-dark tests in male C57BL/6J mice, while performance in the marble-burying test was not impacted. Furthermore, genetic ablation of GIRK channels in CA3/DG excitatory neurons precluded the suppression of avoidance behavior evoked by systemic ML297 in the EPM test. Thus, acute inhibition of excitatory neurons in the ventral CA3 and DG subregions of the vHPC is necessary for the apparent anxiolytic efficacy of systemic ML297 and is sufficient to decrease innate avoidance behavior in male C57BL/6J mice.<b>SIGNIFICANCE STATEMENT</b> We interrogated the cellular mechanisms underlying the apparent anxiolytic efficacy of ML297, a selective activator of G-protein-gated inwardly rectifying K<sup>+</sup> (GIRK) channels and promising lead compound. Intracranial infusion of ML297 into the ventral hippocampus (vHPC) and basolateral amygdala (BLA) complex exerted opposing influence on innate avoidance behavior in male C57BL/6J mice, the former recapitulating the suppression of avoidance behavior evoked by systemic ML297. Using viral genetic and chemogenetic approaches, we showed that combined inhibition of excitatory neurons in CA3 and dentate gyrus (DG) subregions of the vHPC is sufficient to decrease innate avoidance behavior in male mice and mediates the decrease in avoidance behavior evoked by systemic ML297. These findings establish a foundation for future investigations into the therapeutic potential of GIRK channel modulation in anxiety disorders.
Iron complexes of tris(4-nitrophenyl)corrole, with emphasis on the (nitrosyl)iron complex (2012)

The iron complexes of 5,10,15-tris(4-nitrophenyl)corrole have been prepared and characterized by various spectroscopic techniques. The (nitrosyl)iron complex is diamagnetic and its X-ray structure reveals an almost perfectly linear Fe–N–O bond. EPR spectroscopy in conjunction with 15 N labelling were used to deduce the redox centre of the one-electron reduction and oxidation products of the (nitrosyl)iron corrole.
In vitro prediction of in vivo skin damage associated with the wiping of dry tissue against skin (2012)

We observed significant correlation between bench and clinical methods for measuring skin damage caused by wiping of skin with tissue. The bench method will facilitate rapid and inexpensive skin gentleness assessment of cleansing materials.
Windshield cleaning robot system: WSC (2002)

This paper describes the development of a windshield cleaning robot system (WSC). The WSC is intended to be used for Boeing 747 aircraft parked at airports prior to service. The objects to be cleaned are spots on the windshield caused by collision with dust, insects, and birds during takeoff and landing. The WSC was developed with the objective of realizing a system which could be operated by a single operator able to complete the work on one aircraft in 10 minutes. The WSC consists of the manipulator (the arm and the cleaning device), the installation unit, the control unit, and the operation unit. A position and force control method is applied to the WSC. The target position of the arm tip is modified by using the signals from the force sensor and the joystick. In accordance with this control method, the pressure force is kept constant and the tip is moved so as to follow the shape of the workpiece. The various safety features provided include an interference limit to limit the area of movement of the arm tip. System evaluation experiments were carried out and the effectiveness of applying a lightweight manipulator with long arms to this work was confirmed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhancement and inhibition of spontaneous emission in room-temperature semiconductor microcavities with metallic mirrors (2005)

Summary form only given. We report the observation, at room temperature, of both enhancement and inhibition of the spontaneous emission due to the band-to-band transitions in InGaAs quantum wells, placed inside planar semiconductor microcavities with silver mirrors. In addition to the presentation of the experimental and theoretical results, we discuss the implications of these experiments on the physics of the electron-hole bimolecular recombination and on the possibility of exploiting the control of spontaneous emission in room temperature, electrically pumped, optoelectronic devices.
The dog that didn't bark at Buenos Aires (1999)

Compte rendu des discussions sur les mecanismes de compensation des efforts de reduction des emissions de CO 2 , au sommet de Buenos Aires, en novembre 98. Presentation des activites de Carbon Storage Trust, une organisation non gouvernementale, basee au Royaume Uni, qui oeuvre dans le domaine de la preservation de l'environnement
Self-healing narrowband filters via 3D heterogeneous integration of AlN MEMS and CMOS chips (2017)

We demonstrated the statistical element selection (SES) technique with an array of 1.15 GHz AlN MEMS subfilters fabricated in an 8” Si fabrication facility by A*STAR, Institute of Microelectronics (IME), Singapore. The chip integration is achieved through a split-fab process where the hermetically thin-film-encapsulated (TFE) MEMS resonators are solder-bump bonded to a CMOS chip fabricated in a Samsung 28 nm process. The SES offers 495 unique filter frequency responses with a tuning range of 150 kHz for the center frequency (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) and 250kHz for the bandwidth (BW). An insertion loss (IL) <; 3.4 dB and an out-of-band rejection (OBR) > 15 dB were also achieved for the same self-healing filter. Compared to RF signal routing on CMOS, the use of redistribution layers (RDL) on the MEMS chip reduced the routing parasitic capacitance by ~20x and the resistance by ~5x, which, in turn, led to a direct 50 Ω matching.
PD08-02 EVALUATING THE FOUR KALLIKREIN PANEL OF THE 4KSCORE FOR PREDICTION OF HIGH-GRADE PROSTATE CANCER IN MEN IN THE CANARY PROSTATE ACTIVE SURVEILLANCE STUDY (PASS) (2016)

INTRODUCTION AND OBJECTIVES: Prior to diagnosis, the 4Kscore improves the prediction of high grade cancers over total PSA and age alone. We investigated utility of the four kallikrein (4K) panel (including age) of the 4Kscore to predict the presence of occult highgrade disease in men with Gleason 6 cancer on active surveillance in the multi-institutional Canary PASS.
A rearrangement of 1,1-linked four-membered rings to bicyclic bridgehead five-membered rings: A phosphorus turn (2009)

Novel rearrangements of 2,3,2',3'-tetra-tert-butyl-4,4'-bis-trimethylsilanyloxy-1,2,1',2'-tetrahydro-[1,1']biphosphetyl (7) to 1,2,5,6-tetra-tert-butyl-3,7-bis-trimethylsilanyloxy-1H,5H-[1,2]diphospholo-[1,2-a][1,2]diphosphole (9) and of 3,4,3,4-tetra-tert-butyl-[1,1']biphosphetanyl-2,2'-dione (10) to 2,3,6,7-tetra-tert-butyl-tetrahydro-[1,2]diphospholo[1,2-a][1,2]diphosphole-1,5-dione (12) were observed during sublimation at 150 degrees C in 0.1 mm vacuum. The C-P-C internal angles of the four-membered rings, which reflect steric strain in (7), were 71.9(2) degrees and 77.9(1) degrees; the C-P-P internal angles of the five-membered rings of 9 were 90.88(6) degrees and 93.02(6) degrees after rearrangement. Reaction of 7 with metallic caesium provided the caesium salt of 3,4-di-tert-butyl-3,4-dihydro-phosphet-2-ol (15), which is the first example of a 2lambda-3-phospha-1-enolate being incorporated into four-membered ring. Due to its large size, the caesium cation has a rare coordination mode with both the phosphorus and oxygen atoms of the 2lambda-3-phospha-1-enolate, forming infinite polymeric chains in the solid state of 15. Two tert-butyl groups in the vicinal positions of compounds 7, 9, 10, 12 and 15 dictate the gauche conformations in compounds 7, 9, 10, 12 and 15, enforcing this stereoselectivity around the C-C-C portion of the rings in the enlargement reaction.
A ccg-based method for training a semantic role labeler in the absence of explicit syntactic training data (2011)

Treebanks are a necessary prerequisite for many NLP tasks, including, but not limited to, semantic role labeling. For many languages, however, treebanks are either nonexistent or too small to be useful. Time-critical applications may require rapid deployment of natural language software for a new critical language—much faster than the development time of a traditional treebank. This dissertation describes a method for generating a treebank and training syntactic and semantic models using only semantic training information—that is, no human-annotated syntactic training data whatsoever. This will greatly increase the speed of development of natural language tools for new critical languages in exchange for a modest drop in overall accuracy. Using Combinatory Categorial Grammar (CCG) in concert with Propbank semantic role annotations allows us to accurately predict lexical categories in combination with a partially hidden Markov model. By training the Berkeley parser on our generated syntactic data, we can achieve SRL performance of 65.5% without using a treebank, as opposed to 74% using the same feature set with gold-standard data.
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble (2019)

Type III-A CRISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-RNA complex, Csm, for transcription-dependent immunity against foreign DNA. Csm can cleave RNA and single-stranded DNA (ssDNA), but whether it targets one or both nucleic acids during transcription elongation is unknown. Here, we show that binding of a Thermus thermophilus (T. thermophilus) Csm (TthCsm) to a nascent transcript in a transcription elongation complex (TEC) promotes tethering but not direct contact of TthCsm with RNA polymerase (RNAP). Biochemical experiments show that both TthCsm and Staphylococcus epidermidis (S. epidermidis) Csm (SepCsm) cleave RNA transcripts, but not ssDNA, at the transcription bubble. Taken together, these results suggest that Type III systems primarily target transcripts, instead of unwound ssDNA in TECs, for immunity against double-stranded DNA (dsDNA) phages and plasmids. This reveals similarities between Csm and eukaryotic RNA interference, which also uses RNA-guided RNA targeting to silence actively transcribed genes.
THE EFFECT OF LAMINA PROPRIA CELLS ON THE GROWTH OF UROTHELIAL AND SMOOTH MUSCLE CELLS (2009)

You have accessJournal of Urology1 Apr 2009THE EFFECT OF LAMINA PROPRIA CELLS ON THE GROWTH OF UROTHELIAL AND SMOOTH MUSCLE CELLS Roberto Soler, Claudius Fullhase, Nadia Guimaraes-Souza, Karl-Erik Andersson, and James J Yoo Roberto SolerRoberto Soler More articles by this author , Claudius FullhaseClaudius Fullhase More articles by this author , Nadia Guimaraes-SouzaNadia Guimaraes-Souza More articles by this author , Karl-Erik AnderssonKarl-Erik Andersson More articles by this author , and James J YooJames J Yoo More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60225-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "THE EFFECT OF LAMINA PROPRIA CELLS ON THE GROWTH OF UROTHELIAL AND SMOOTH MUSCLE CELLS." The Journal of Urology, 181(4S), p. 78 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 78 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Roberto Soler More articles by this author Claudius Fullhase More articles by this author Nadia Guimaraes-Souza More articles by this author Karl-Erik Andersson More articles by this author James J Yoo More articles by this author Expand All Advertisement PDF downloadLoading ...
96-69: Rapid estimation of 3D ventricular activation from electroanatomic mapping (2016)

Purpose: Heart failure patients are often affected by a ventricular conduction disorder. Accurate characterization of the tridimensional (3D) activation sequence of the ventricles is fundamental for an effective personalized therapy. Electroanatomical mapping provides the activation times at the endocardium, with limited coverage due to anatomical constraints. Our aim is to develop a robust tool to generate a complete 3D, biventricular activation map from a limited number of endocardial measurements. Method: In 6 candidates to cardiac resynchronization therapy a high density endocardial activation map of the right and left ventricle was obtained. High resolution propagating activation was simulated in patient-tailored anatomical heart models using the anisotropic eikonal equation and realistic fiber orientation. The mean square error between the measured and simulated activation times was minimized by repeated simulations, varying early activation site(s) and local anisotropic conduction velocities. The mathematical formulation is flexible in terms of the number of activation sites and a possible delay between them, in order to mimic the presence of a partially working Purkinje network. Results: A close correlation was achieved between the simulated and measured activation time for a single patient (Panel A) while detailed 3D activation maps were achieved (Panel B and C). Each individual estimation of the activation map took less than 2 seconds, and the optimal parameters were identified within a few minutes. A 0.9 to 0.95 correlation between measured and simulated activation times was obtained in all cases.
Demonstration of a simple approach for sub‐microliter fluorescence detection by structured PDMS cuvette with TiO 2 nanoparticle inclusion using 3D printing technology (2022)

Abstract With the increasing importance of portable sensing devices, one keeps seeking possible optimization to detect the lower concentration of target molecules with reduced reagents. Here presents a method to enhance fluorescence detection through a miniature cylindrical lens integrated into an engineered PDMS cuvette with a high refractive index embedded TiO 2 nanoparticles. 3D printing technique was used to develop the moulds where the custom cuvette is produced utilizing the imprinting method. LED transmitter and blue laser diode were used as the excitation light sources to verify the light and materials interactions. In all the experiments, the fluorescence detection system was set at 90° alignments without any filters. First, the square‐shaped cuvette resulted in more fluorescence detection compared to the circular one. Hence, different fluorophore holders with square shapes were designed to investigate the efficiency of the integrated lens and the TiO 2 nanoparticles inclusions. Overall, the customized cuvette with integrated lens and nanoparticles demonstrated the most significant signal enhancement that reached the lower detection limit as 10 n M /L in 1 μL detection volume. This structural and material‐modified cuvette can significantly enhance fluorescent detection at a sub‐microliter scale, allowing further device miniaturization, especially for micro and nano fluidic devices using optical detection.
Crystallization and preliminary X-ray diffraction analysis of proximal thread matrix protein 1 (PTMP1) fromMytilus galloprovincialis (2014)

In order to deal with the dynamic ocean environment, blue mussels adhere to various surfaces via their collagenous byssal threads. PTMP1 (proximal thread matrix protein 1) is one identified matrix protein residing in the proximal thread and is capable of collagen binding. Its sequence comprises two von Willebrand factor type A-like repeats. In order to characterize the structure and domain architecture of PTMP1, recombinant protein was crystallized by vapour diffusion. The obtained crystals diffracted to 1.95 Å resolution and belonged to space group P2₁, with unit-cell parameters a=62.0, b=62.3, c=122.6 Å, β=102.2°. The Matthews coefficient suggested the presence of two monomers in the asymmetric unit and 48.3% solvent content.
An Evaluation of the Possible Protective Effects of Neonatal Striatal TransplantsAgainst Kainic Acid‐Induced Lesions (1991)

The present study examined the recent report that transplantation of neonatal striatal tissue into kainic acid (KA) lesioned striatum protected the contralateral striatum from a subsequent KA lesion. We did not find a significant difference in the survival rate of animals that received neonatal striatal transplants into a KA lesioned striatum followed by a subsequent lesion of the contralateral striatum compared to those animals that received bilateral KA-induced striatal lesions alone. The tissue transplants did not protect against the degeneration of striatal neurons induced by KA. Indeed, the survival rate was very low (25%) in the transplant groups. A second experiment was also performed to examine whether a neonatal striatal transplant might reduce the severe syndrome of aphagia and adipsia associated with KA lesions of the striatum. Animals that received the neonatal striatal transplants showed increased aphagia and adipsia compared to animals only receiving the KA lesion. Again, the transplant group had a very low survival rate (10%). The present study was unable to confirm that neonatal striatal transplants protect against KA lesions either by themselves or in conjunction with a recent KA lesion.
Transcriptomic and metabolomic profiling of Zymomonas mobilis during aerobic and anaerobic fermentations (2009)

High oxygen concentrations present during Z. mobilis fermentations negatively influence fermentation performance. The maximum specific growth rates were not dramatically different between aerobic and anaerobic conditions, yet oxygen did affect the physiology of the cells leading to the buildup of metabolic byproducts that ultimately led to greater differences in transcriptomic profiles in stationary phase.
Modeling documents with a Deep Boltzmann Machine (2013)

We introduce a type of Deep Boltzmann Machine (DBM) that is suitable for extracting distributed semantic representations from a large unstructured collection of documents. We overcome the apparent difficulty of training a DBM with judicious parameter tying. This enables an efficient pretraining algorithm and a state initialization scheme for fast inference. The model can be trained just as efficiently as a standard Restricted Boltzmann Machine. Our experiments show that the model assigns better log probability to unseen data than the Replicated Softmax model. Features extracted from our model outperform LDA, Replicated Softmax, and DocNADE models on document retrieval and document classification tasks. 1
ChemInform Abstract: Highly Enantioselective Imine Hydrosilylation Using (S,S)‐Ethylenebis(. eta.5‐tetrahydroindenyl)titanium Difluoride. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.