gebhart/patrepeval huggingface dataset:
Improving data center resource management, deployment, and availability with virtualization (2011)

The increasing demand for storage and computation has driven the growth of large data centers—the massive server farms that run many of today's Internet and business applications. A data center can comprise many thousands of servers and can use as much energy as a small city. The massive amounts of computation power contained in these systems results in many interesting distributed systems and resource management problems. In this thesis we investigate challenges related to data centers, with a particular emphasis on how new virtualization technologies can be used to simplify deployment, improve resource efficiency, and reduce the cost of reliability, all in application agnostic ways. 
We first study problems that relate to the initial capacity planning required when deploying applications into a virtualized data center. We demonstrate how models of virtualization overheads can be utilized to accurately predict the resource needs of virtualized applications, allowing them to be smoothly transitioned into a data center. 
We next study how memory similarity can be used to guide placement when adding virtual machines to a data center, and demonstrate how memory sharing can be exploited to reduce the memory footprints of virtual machines. This allows for better server consolidation, reducing hardware and energy costs within the data center. We then discuss how virtualization can be used to improve the performance and efficiency of data centers through the use of “live” migration and dynamic resource allocation. We present automated, dynamic provisioning schemes that can effectively respond to the rapid fluctuations of Internet workloads without hurting application performance. We then extend these migration tools to support seamlessly moving applications across low bandwidth Internet links. 
Finally, we discuss the reliability challenges faced by data centers and present a new replication technique that allows cloud computing platforms to offer high performance, no data loss disaster recovery services despite high network latencies.
A Liquid-Piston Steam Engine (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Recently, waste heat recovery system from automobile exhaust gas has attracted a lot of attention as one of the promising technology to improve fuel efficiency and to reduce carbon dioxide emission. In order to put this system into practice, we developed a novel liquid-piston steam engine which has large potential of high efficiency, high reliability and low cost. Thermal efficiency of 12.7 % is achieved at temperatures of &lt;i&gt;T&lt;sub&gt;h&lt;/sub&gt;&lt;/i&gt; = 270 °C and &lt;sub&gt;&lt;i&gt;l&lt;/i&gt;&lt;/sub&gt; = 80 °C. Finally, electrical output of waste heat recovery system with the liquid-piston steam engine is estimated to be 44 or 79Wh under NEDC or HWFET modes, respectively.&lt;/div&gt;&lt;/div&gt;
Effects of Alloy Composition on Multilevel Operation in Self-Heating Phase Change Memories (2011)

Although PCM presents good scaling properties, multilevel storage may be required to increase bit density and reduce the cost per bit. The aim of this paper is to evaluate the impact of different phase change (PC) materials based on GST and GeTe on the feasibility of partial-RESET multilevel programming in self-heating device architectures. Through an accurate analysis of electrical and thermal characteristics of these devices, it is demonstrated that GeTeN10% and GST appear to be the best candidates to assure multilevel operation in such architectures.
Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits (2020)

Paclitaxel drug-coated balloons (DCBs) reduce restenosis, but their overall safety has recently raised concerns. This study hypothesized that DCBs could lessen inflammation and reduce plaque progression. Using 25 rabbits with cholesterol feeding- and balloon injury-induced lesions, DCB-percutaneous transluminal angioplasty (PTA), plain PTA, or sham-PTA (balloon insertion without inflation) was investigated using serial intravascular near-infrared fluorescence-optical coherence tomography and serial intravascular ultrasound. In these experiments, DCB-PTA reduced inflammation and plaque burden in nonobstructive lesions compared with PTA or sham-PTA. These findings indicated the potential for DCBs to serve safely as regional anti-atherosclerosis therapy.
Building on the essential foundation of physiology (2020)

disease.The need for this added value is not likely to change.In-depth training in physiology is foundational to the subspecialty, as it is for other pediatric subspecialties like as cardiology and nephrology.To apply all the scientific advances and knowledge gained in the last few yearsand anticipated in the future-training in classic physiology will need to be augmented with additional education in the cellular, molecular, and genetic basis of respiratory function and disease as outlined in the editorial.We would like to amplify the principle, mentioned in the editorial, that comprehensive training in physiology will always constitute a core competency for pediatric pulmonologists.Therefore, more time for training in science, rather than less, is needed during fellowship.We believe that the founders would agree.
Modeling learning effects in mobile texting (2008)

No work on mobile text messaging so far has taken into account the effect of learning on the change in visual exploration behavior as users progress from non-expert to expert level. We discuss within the domain of multi-tap texting on mobile phone and address the process of searching versus selecting a letter on the keypad interface. We develop a simulation model that forecasts the probability of letter location recall by non-expert users and thereby models learning, as the user acquires expertise in recalling, with practice, session after session. We then plugin this probability within a model of visual strategy that combines the effect of different ways visual exploration: non-expert users search for a letter while expert users select a letter. The observed non-expert non-motor time preceding a key press (for a letter) correlates extremely well with the simulation results.
Simple mucin-type carbohydrate antigens in major salivary glands. (1994)

Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well-defined monoclonal antibodies (MAb) on frozen and paraffin-embedded normal salivary gland tissue from 22 parotid, 14 submandibular, six sublingual, and 13 labial glands to elucidate the simple mucin-type glycosylation pattern in relation to cyto- and histodifferentiation. The investigated carbohydrate structures were predominantly observed in the cell cytoplasm, most often in the supranuclear area, suggesting localization to the Golgi region, whereas ductal contents were unstained. Mucous acinar cells expressed Tn, sialosyl-Tn, and H and A antigens, regardless of glandular location. Serous acinar cells, on the other hand, expressed A, H, and inconstantly sialosyl-T, Tn, and sialosyl-Tn antigens in major salivary glands, whereas serous cells of minor (labial) salivary glands expressed H exclusively, Tn and sialosyl-T antigens inconstantly, but never sialosyl-Tn and A antigens. The difference may be related to a more simple cytodifferentiation of serous cells of minor (labial) salivary glands as compared with major salivary glands. Duct cells in major salivary glands expressed A, H, and inconstantly T, sialosyl-T, and Tn antigens, whereas minor (labial) salivary glands ducts exclusively expressed H, T and sialosyl-T antigens, differences that may be related to dissimilarities in the duct system. Myoepithelial cells and basal cells exclusively expressed T and sialosyl-T antigens, which may prove useful in studies of salivary gland tumors, since these cells are known to play a key role in the histological characteristics of some salivary gland tumors. The results indicate a similar glycosylation pattern in the different major salivary glands, whereas minor (labial) salivary gland differ slightly in serous and duct cells. The limited and exclusive intracellular expression of the immature Tn, sialosyl-Tn, and T antigens indicates that these structures may be of value as markers of salivary gland tumors.
El péptido liberador de la Hormona de Crecimiento-6 (GHRP6) reduce la fibrosis del hígado en ratas intoxicadas crónicamente con CCl4 (2012)

La fibrosis es causa fundamental de morbilidad y mortalidad. Los tratamientos actuales han fracasado. El peptido liberador de la hormona de crecimiento-6 (GHRP6) ejerce efectos cardioprotectores, pero no se ha descrito su accion antifibrotica. Se examino la propiedad del GHRP6 para prevenir y revertir la cirrosis hepatica, luego de su induccion en ratas mediante la administracion de CCl4. Se evaluo el porcentaje de grasa hepatica, fibrosis, nodularidad y grosor septal mediante estudios histomorfometricos y la ascitis o dilatacion portal por ultrasonido. Se determino el perfil bioquimico y los parametros de estres oxidativo en suero, asi como la participacion de genes y proteinas, mediante reaccion en cadena de la polimerasa con transcripcion inversa e inmunohistoquimica. Se utilizo un microarreglo de oligonucleotidos del genoma de rata para estudiar el perfil de expresion de los genes inducidos por el GHRP6. La intervencion concomitante con GHRP6 previno la induracion fibrotica en mas del 85% (p < 0.0001). La administracion terapeutica durante 15 dias permitio la remocion fibrotica del 37% (p = 0.0004), la reduccion del grosor septal supero el 30% (p = 0.0011). La administracion durante 60 dias redujo las areas fibroticas en 75%, y la reduccion de la nodularidad fue de mas del 60%. El GHRP6 redujo el dano oxidativo porque aumento la actividad de las enzimas antioxidantes y las celulas estrelladas activadas positivas a vimentina y actina alfa de musculo liso. Tambien redujo la expresion de factores fibrogenicos sobre las celulas Kupffer. El perfil de expresion de genes indico que el GHRP6 modula el balance redox y la respuesta al dano tisular en las celulas parenquimales. Estas evidencias sugieren que el GHRP6 pudiera controlar la respuesta fibroplasica del higado
T1 hypointense lesions in secondary progressive multiple sclerosis: effect of interferon beta-1b treatment (2001)

Recently, the clinical efficacy of interferon beta-1b (IFNbeta-1b) was demonstrated for secondary progressive (SP) multiple sclerosis in a European multicentre study. We evaluated the effect of IFNbeta-1b treatment on the rate of development of hypointense T(1) MRI lesions, a putative marker of axonal damage. Unenhanced T(1)-weighted images were obtained in a subgroup of 95 multiple sclerosis patients from five centres at 6-month intervals; this subgroup was similar to the total study population for all demographic, clinical and MRI parameters. An experienced observer blinded to the clinical data and treatment allocation measured volumes. The median baseline lesion load for hypointense T(1) lesions was 5.1 cm(3) for placebo-treated and 4.9 cm(3) for IFNbeta-1b-treated patients (P = 0.56). Placebo-treated patients showed an increase in T(1) lesion load by a median of 14% per year (P = 0.0002 compared with baseline); this was reduced to 7.7% per year in the IFNbeta-1b-treated patients (P = 0.003 versus placebo). In the IFNbeta-1b arm there was a statistically significant correlation between absolute change in Expanded Disability Status Scale scores and T(1) lesion load by month 36 (r = 0.38, P = 0.0015). In patients with SP multiple sclerosis, IFNbeta-1b treatment reduces the development of hypointense T(1) lesions, suggesting that reduced axonal damage in lesions may play a part in the beneficial effect that is observed clinically.
Quantitative 3-dimensional profiling of channel networks within transparent ‘lab-on-a-chip’ microreactors using a digital imaging method (2001)

We have developed a method for the quantitative 3-dimensional profiling of micron sized channel networks within optically transparent "lab-on-a-chip" microreactor devices. The method involves capturing digitised microscope images of the channel network filled with an optically absorbing dye. The microscope is operated in transmission mode using light filtered through a narrow bandpass filter with a maximum transmission wavelength matching the wavelength of the absorbance maximum of the dye solution. Digitised images of a chip filled with solvent and dye solution are analysed pixel by pixel to yield a spatially resolved array of absorbance values. This array is then converted to optical path length values using the Beer-Lambert law, thereby providing the 3D profile of the channel network. The method is capable of measuring channel depths from 10 to 500 microm (and probably even smaller depths) with an accuracy of a few percent. Lateral spatial resolution of less than 1 microm is achievable. It has been established that distortion of the measured profiles resulting from a mismatch in refractive index between the dye solution and the glass of the microreactors is insignificant. The method has been successfully used here to investigate the effects of thermal bonding and etch time on channel profiles. The technique provides a convenient, accurate and non-destructive method required to determine channel profiles; information which is essential to enable optimisation of the operating characteristics of microreactor devices for particular applications.
ChemInform Abstract: Scaffold Topologies. Part 2. Analysis of Chemical Databases. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum (2019)

Abstract There is a Blood Commentary on this article in this issue.
Effect of Silane Coupling Agents on Compression Molding for Magnetic Filler Composites (2006)

Recently, high performance of noise suppression materials heve been required to suppress the electromagnetic noise generated from high frequencies of circuits and chips in electronic equipment. These are usually supplied as a sheet of filler composite consisting of magnetic powder and polymeric binder. High packing of soft magnetic powder within the sheet produces a significant suppression of electromagnetic noise. Therefore, silane was applied to magnetic powder with various kinds of silanes such as ionic, amino, methacrylic, vinyl, and epoxy silanes to increase packing of the filler within the binder. The packing was evaluated from the void calculated by specific gravity of the magnetic filler composite sheet. All silanes have lowered the void in the composite. This effect increases in the following order; epoxy, vinyl, methacrylic, amino, and ionic silanes. This means that ionic property of silane gives affinity to the binder. As a result, the magnetic permeability increases with specific gravity of the filler composite modified by the treatment with various kinds of silanes. Finally, the occurrence of the void was examined from the torque values of a twin axis mixing mill and also observed from a soft X ray image. The resulting value of the torque in the milling is not dependent on the kinds of silanes used in treating the filler. This means that the size of the void arises not from the mechanical process of milling, but mainly from the surface treatment with silane. In the observation of voids by the X-ray imaging, there are not only a lot of voids but also aggregates of the filler in a sheet of filler composites without surface treatment. Silane treatment significantly reduces voids and aggregates. In conclusion, silane treatment plays an important role on the homogeneous spread of the filler into the polymeric binder.
The Physiological Significance of the Glucose Intolerance of Aging (1984)

Aging is associated with glucose intolerance, but its significance is unclear. We performed oral glucose tolerance tests and more physiologic meal tolerance tests in a group of 23 young adults, mean (+/- SE) age, 37 +/- 2 years and 17 elderly adults, mean age 69 +/- 1 years. The total glucose and insulin responses following the oral glucose load were increased by 24% and 127% respectively in the elderly compared with the young (24,524 +/- 1,080 vs. 19,734 +/- 702 mg/dl X min and 24,289 +/- 3,401 vs. 10,700 +/- 1,209 microU/ml X min). Following mixed meals, the total glucose response was 45,795 +/- 1,343 mg/dl X min in the young, compared with 50,998 +/- 1,850 mg/dl X min in the elderly (p less than .05) an 11% increase. Total insulin response was increased by 40% in the elderly (38,590 +/- 3,662 microU/ml X min) compared with the young (27,481 +/- 2,805 microU/ml X min) (p less than .05). We conclude that following the ingestion of more physiologic mixed meals, modest postprandial hyperglycemia and hyperinsulinemia can be demonstrated in elderly adults.
Associating particle tracking with laser fringe anemometry (1980)

In order to obviate the complementary limitations of velocimetry by laser fringe anemometry and by photographic particle tracking, a family of optical systems is described which is suitable for both types of measurement over extended test regions. It is based on a thin sheet of light from a powerful CW laser which is broken into fine interference fringes in its plane and interrupted at a known frequency. Depending on the divergence and energy density of the beam, various applications are considered ranging from test areas as large as those required in fire research to those more characteristic of high velocity applications which involve test space dimensions of several centimetres. The conflicting criteria of visibility of tracer particles and their ability to follow variations in gas flow are examined for these regimes. Among other capabilities of such systems are the addition of a third dimension by using multiple sheets of light, and the use of the fringes as visible 'ray trajectories' in deflection tracing through refractive index gradients.
Correction to “Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening"Weijun Shen, Matthew S. Tremblay, Vishal A. Deshmukh, Weidong Wang, Christophe M. Filippi, George Harb, You-qing Zhang, Anwesh Kamireddy, Janine E. Baaten, Qihui Jin, Tom Wu, Jonathan G. Swoboda, Eric C. Peters, Charles Y. Cho, Jing Li, Bryan A. Laffitte, Peter McNamara, Richard Glynne*, Xu Wu, Ann E. Herman, and Peter G. Schultz*Cite this: J. Am. Chem. Soc. 2013, 135, 11, 4573Publication Date (Web):March 6, 2013Publication History Published online6 March 2013Published inissue 20 March 2013https://pubs.acs.org/doi/10.1021/ja401118ghttps://doi.org/10.1021/ja401118gcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1178Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (128 KB) Get e-Alertsclose Get e-Alerts
Joint capacity and quality evaluation for AMR telephony speech in WCDMA systems (2003)

The adaptive multi-rate (AMR) speech codec is the mandatory speech codec for WCDMA systems. The codec supports eight different source rates ranging from 12.2 kbit/s down to 4.75 kbit/s. This paper evaluates different ways of allocating AMR rates to users on the downlink in a WCDMA system. A novel system performance concept is introduced based on a user satisfaction metric that tries to combine the user experience from different speech quality levels as well as events like blocking and dropping. System simulations show that the AMR codec introduces a significant trade-off between capacity and quality for the speech service. By allocating AMR modes based on the system load, the quality and capacity trade-off can be efficiently balanced and high system performance can be achieved for a wide range of offered loads.
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting (2013)

Flow-cytometric detection of minimal residual disease (MRD) has proven in several single-institute studies to have an independent prognostic impact. We studied whether this relatively complex approach could be performed in a multicenter clinical setting. Five centers developed common protocols to accurately define leukemia-associated (immuno)phenotypes (LAPs) at diagnosis required to establish MRD during/after treatment. List mode data files were exchanged, and LAPs were designed by each center. One center, with extensive MRD experience, served as the reference center and coordinator. In quarterly meetings, consensus LAPs were defined, with the performance of centers compared with these. In a learning (29 patients) and a test phase (35 patients), a mean of 2.2 aberrancies/patient was detected, and only 1/63 patients (1.6%) had no consensus LAP(s). For the four centers without (extensive) MRD experience, clear improvement could be shown: in the learning phase, 39-63% of all consensus LAPs were missed, resulting in a median 30% of patients (range 21-33%) for whom no consensus LAP was reported; in the test phase, 27-40% missed consensus LAPs, resulting in a median 16% (range 7-18%) of 'missed' patients. The quality of LAPs was extensively described. Immunophenotypic MRD assessment in its current setting needs extensive experience and should be limited to experienced centers.
321 Compression properties of functionally graded porous aluminum fabricated by tool-traversing friction powder sintering process (2015)

Porous aluminum (Al) was fabricated by a tool-traversing friction powder sintering process. In this process, a mixture of Al powder and sodium chloride (NaCl) powder as spacer particles was used as a starting material. The powder mixture was placed in a mold, compaction and sintering of the mixture was conducted only by the traversing of a rotating tool as in friction stir welding. In this study, functionally graded porous aluminum was fabricated by a tool-traversing friction powder sintering process which had different range of porosity of 60%, 70% and 80%. By X-ray computing tomography observation, it was found that the fabricated functionally graded porous Al had uniform pore distribution in each porosity range. By compression tests, it was shown that the plateau stress was decreased with the increased in porosity. Consequently, it was shown that compression properties of functionally graded porous Al can be controlled by volume fraction of NaCl.