gebhart/patrepeval huggingface dataset:
Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers (2023)

The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens to mitigate side effects. Here, we identify a dexamethasone-GR mediated anti-cancer response in a subset of aggressive non-small cell lung cancers (NSCLCs) that harbor Serine/Threonine Kinase 11 (STK11/LKB1) mutations. High tumor expression of carbamoyl phosphate synthase 1 (CPS1) was strongly linked to the presence of LKB1 mutations, was the best predictor of NSCLC dexamethasone (DEX) sensitivity (<i>p</i> < 10<sup>-16</sup>) but was not mechanistically involved in DEX sensitivity. Subcutaneous, orthotopic and metastatic NSCLC xenografts, biomarker-selected, STK11/LKB1 mutant patient derived xenografts, and genetically engineered mouse models with KRAS/LKB1 mutant lung adenocarcinomas all showed marked <i>in vivo</i> anti-tumor responses with the glucocorticoid dexamethasone as a single agent or in combination with cisplatin. Mechanistically, GR activation triggers G1/S cell cycle arrest in LKB1 mutant NSCLCs by inducing the expression of the cyclin-dependent kinase inhibitor, <i>CDKN1C</i>/p57(Kip2). All findings were confirmed with functional genomic experiments including CRISPR knockouts and exogenous expression. Importantly, DEX-GR mediated cell cycle arrest did not interfere with NSCLC radiotherapy, or platinum response <i>in vitro</i> or with platinum response <i>in vivo</i>. While DEX induced LKB1 mutant NSCLCs <i>in vitro</i> exhibit markers of cellular senescence and demonstrate impaired migration, <i>in vivo</i> DEX treatment of a patient derived xenograft (PDX) STK11/LKB1 mutant model resulted in expression of apoptosis markers. These findings identify a previously unknown GR mediated therapeutic vulnerability in STK11/LKB1 mutant NSCLCs caused by induction of p57(Kip2) expression with both STK11 mutation and high expression of CPS1 as precision medicine biomarkers of this vulnerability.
Proposal of a Design Method for Dismantling Products with Split-Lines (2015)

Abstract An important process for the reuse and recycling of end of life products is their disassembly. In general, manual disassembly is a labor intensive and costly process. Especially, removing fasteners takes time and cost. For solving this problem, this paper proposes a design method for the partial dismantling of products with split-lines, which are added to the products at the design phase and enable to destruct the products along the line in order to extract target components. This method supports a designer in determining the location of split-lines by using the geometric model of the product. A case study shows that the dismantling of a LCD TV with split-lines reduces the number of manual operations needed for extracting target components.
An Investigation Into the Heat Transfer and Fluid Flow Around a Circular Cylinder in Buoyancy Assisting Cross Flow (2002)

There is considerable interest in mixed convection heat transfer in relation to electronic cooling applications but the physics of this flow in certain situations has yet to be understood. In this paper, an investigation of the heat transfer and fluid flow around a two dimensional circular cylinder is made. The experimental configuration comprised a long heated cylinder suspended in a glass walled enclosure. The airflow within the enclosure was controlled using a baffled axial fan to give a range of low Reynolds numbers from 30 to 83. For three Grashof numbers of 2.40E+04, 3.77E+04 and 5.99E+04, the mean Nusselt number around the cylinder was measured for buoyancy assisting cross flow. Optical techniques were employed to extract the full flow and temperature fields about the cylinder. Digital Speckle Pattern Interferometry (DSPI) was employed to measure the temperature field, and Particle Image Velocimetry (PIV) for the velocity field. The presence of the assisting flow was found to stabilise a naturally oscillatory buoyant flow and led to an increase in the heat transfer coefficient over that found in natural flow.
The Impact of Lens Vault on Visual Acuity and Refractive Error (2015)

The magnitude of LV was not associated with VA or spherical equivalent. Lens extraction may be a consideration in eyes with angle closure with large LV in the absence of visually significant cataract.
Bioinformatics process management: information flow via a computational journal (2007)

This paper presents the Bioinformatics Computational Journal (BCJ), a framework for conducting and managing computational experiments in bioinformatics and computational biology. These experiments often involve series of computations, data searches, filters, and annotations which can benefit from a structured environment. Systems to manage computational experiments exist, ranging from libraries with standard data models to elaborate schemes to chain together input and output between applications. Yet, although such frameworks are available, their use is not widespread-ad hoc scripts are often required to bind applications together. The BCJ explores another solution to this problem through a computer based environment suitable for on-site use, which builds on the traditional laboratory notebook paradigm. It provides an intuitive, extensible paradigm designed for expressive composition of applications. Extensive features facilitate sharing data, computational methods, and entire experiments. By focusing on the bioinformatics and computational biology domain, the scope of the computational framework was narrowed, permitting us to implement a capable set of features for this domain. This report discusses the features determined critical by our system and other projects, along with design issues. We illustrate the use of our implementation of the BCJ on two domain-specific examples.
Total synthesis of (+)-ophiobolin C (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-ophiobolin CMichael Rowley, Masamitsu Tsukamoto, and Yoshito KishiCite this: J. Am. Chem. Soc. 1989, 111, 7, 2735–2737Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00189a069https://doi.org/10.1021/ja00189a069research-articleACS PublicationsRequest reuse permissionsArticle Views2598Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Elastic and electro-optical properties of flexible fluorinated dimers with negative dielectric anisotropy (2022)

We report the synthesis and the temperature dependencies of optical, dielectric, and elastic properties of four homologous dimeric mesogens in the uniaxial nematic (N) phase. The studied dimers are derived from 2ʹ,3ʹ-difluoroterphenyl units connected via flexible alkyl chains. The compounds differ in the length of either the flexible alkyl chain or the terminal groups. These achiral bimesogens exhibit the twist-bend nematic (NTB) phase with a nanoscale pitch of the modulated nematic director, as established by the freeze-fracture transmission electron microscopy. All four homologs have negative dielectric anisotropy owing to the permanent dipole oriented normal to the long molecular axes. A longer flexible bridge length yields an expanded temperature range of the N phase, stronger dielectric anisotropy, larger birefringence and bend elastic constant K33. Longer alkyl terminal chains increase birefringence but decrease the absolute value of dielectric anisotropy and K33. All four bimesogens show a dramatic decrease of K33 down to ~0.5 pN on approaching the N-NTB transition. A longer bridge yields a longer period of twist-bend modulation in the NTB phase.
How well can Cosmological Parameters be Estimated from CMB Observations (1995)

The CMB anisotropy depends sensitively upon the slope and amplitude of primordial density and gravitational wave fluctuations, the baryon density, the Hubble constant, the cosmological constant, the ionization history, etc. We report on recent work showing how well multi-scale measurements of the anisotropy power spectrum can resolve these factors. We identify a hypersurface in cosmic parameter space that can be accurately localized by observations, but along which the likelihood will hardly vary. Other cosmic observations will be needed to break this degeneracy.
The Effect Of Stationary UV Excitation On The Optical Behavior Of Electrochemically Self-Assembled Semiconductor Nanowires (2006)

In this work, we investigate the optical response of the semiconductor quantum wire array when excited by stationary UV light. The array is synthesized by selectively electro-depositing the semiconductor material in electrochemically self-assembled porous alumina templates. Our studies are based on the optical behavioral changes in CdS, ZnO, ZnSe and CdSe quantum wires of 50-, 25- and 10-nm diameters. We use a set of generalized Bloch equations to solve the interband polarization function of the semiconductors derived within the Hartree-Fock approximation, and theoretically model the UV excitation effect on the quantum wires. The solutions which consider the effects of screening, Coulomb interaction between the carriers and many body effects on excitons are generated for a quasi-equilibrium regime using a devised accelerated fixed point method. The solution technique is developed in Mathematica to iteratively solve this complex set of equations. The optical constants generated for individual quantum wires are incorporated into a finite-element electromagnetic wave simulator, HFSS, to investigate the full behavior of the array of wires. Theoretically calculated values of the dielectric permittivity of the un-excited quantum wires are shown to decrease progressively as the wire diameter reduces. We perform the experimental analysis using a pump-probe excitation scheme incorporated in a sensitive Michelson interferometer in a homodyne setup. We measure extremely small changes in the phase shift between the interfering IR probe beams and hence measure the refractive index changes caused by the UV pump. While the decreasing filling factor acts to reduce the optical activity in narrower wire arrays, the shifting of the DOS function with additional quantum confinement serves to increase it. These competing effects give rise to the size-dependent non-monotonic optical activity experimentally observed in ZnO, CdS and ZnSe nanowire arrays. The simulation results show a rapid increase in the changes in effective permittivity values of the individual quantum wires as diameter decreases. The substantial changes observed in the refractive index for the whole thin film array at intermediate wire diameter sizes may be suitable for optical phase shifting, intensity modulation and switching applications in integrated optical devices.
Packaging of Advanced Micro‐ and Nanosystems (2004)

This chapter contains sections titled: Introduction MEMS Packaging Case Studies-Packaging of Physical Sensors References
ChemInform Abstract: 1,6‐Asymmetric Introduction in Reactions Between 6‐Hydroxy‐5‐methylhex‐ 2‐enyl(tributyl)stannane and Aldehydes Promoted by Tin(IV) Bromide. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of micro- and nanosystems for drug delivery (2008)

Methods for preparing colloidal delivery systems for drugs of different chemical structures have been developed and optimized. Proteins were encapsulated in bioadhesive biodegradable starch microparticles and liposomes from negatively charged and zwitter-ionic soybean phospholipids. Proteins and a poorly watersoluble anticancer drug-tamoxifen-were encapsulated in nanoparticles based on the amphiphilic graft block copolymer dextran-poly(ɛ-caprolactone). In vitro release studies showed sustained release of proteins and tamoxifen in different media.
Drag Free and Attitude Control System Design for the LISA Pathfinder Mission (2004)

The drag free control system design for the LISA Pathfinder Mission is presented. During the scientific measurements, two test masses on board of the spacecraft are put into a pure gravitational free fall around the sensitive axis with an accuracy of about 3×10 -14
Development and characterization of a vector set with regulated promoters for systematic metabolic engineering in Saccharomyces cerevisiae (2012)

A set of vectors was constructed that enable combined and systematic testing of metabolic pathway genes in Saccharomyces cerevisiae. The vectors are available as CEN/ARS and 2 µ-based plasmids with a choice of three inducible promoters, P(GAL1) , P(CUP1) and P(ADH2) . These features offer control over the initiation and level of gene expression. In addition, the vectors can be used as templates to generate PCR fragments for targeted chromosomal integration of gene expression cassettes. Selection markers are flanked by loxP elements to allow efficient CreA-mediated marker removal and recycling after genomic integration. For each promoter, expression of a bacterial lacZ reporter gene was characterized from plasmid-based and integrated chromosomal cassettes, and compared to that of the glycolytic P(PGK1) promoter. Plasmid stabilities were also determined. The promoters showed distinct activity profiles useful for modulating expression of metabolic pathway genes. This series of plasmids with inducible promoters extends our previous vector set carrying the constitutive promoters P(PGK1) , P(TEF1) and P(HXT7-391) .
ChemInform Abstract: Complexes of Borane and N‐Heterocyclic Carbenes: A New Class of Radical Hydrogen Atom Donor. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Association between lower body temperature and increased tau pathology in cognitively normal older adults (2022)

NCT03053908.
Positron emission tomography probe to monitor selected sugar metabolism in vivo (2023)

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA (2021)

Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but mechanisms underlying variable efficacy of treatment are incompletely understood. Our examination of severe infantile onset human SMA tissues obtained at expedited autopsy revealed persistence of developmentally immature motor neuron axons, many of which are actively degenerating. We identified similar features in a mouse model of severe SMA, in which impaired radial growth and Schwann cell ensheathment of motor axons began during embryogenesis and resulted in reduced acquisition of myelinated axons that impeded motor axon function neonatally. Axons that failed to ensheath degenerated rapidly postnatally, specifically releasing neurofilament light chain protein into the blood. Genetic restoration of survival motor neuron protein (SMN) expression in mouse motor neurons, but not in Schwann cells or muscle, improved SMA motor axon development and maintenance. Treatment with small-molecule <i>SMN2</i> splice modifiers beginning immediately after birth in mice increased radial growth of the already myelinated axons, but in utero treatment was required to restore axonal growth and associated maturation, prevent subsequent neonatal axon degeneration, and enhance motor axon function. Together, these data reveal a cellular basis for the fulminant neonatal worsening of patients with infantile onset SMA and identify a temporal window for more effective treatment. These findings suggest that minimizing treatment delay is critical to achieve optimal therapeutic efficacy.
Accelerated damage to blank and antireflectance-coated Ca F 2 surfaces under 157-nm laser irradiation (2003)

Successful insertion of 157-nm lithography into production requires that materials comprising the optical train meet the lifetime requirements of the industry. At present, no degradation of bulk fluoride materials has been observed for at least up to 10<sup>9</sup> pulses. However, last year we reported on the surface damage to fluoride materials that appeared after 3-4x10<sup>9</sup> pulses at moderate fluences of 3-4 mJ/cm<sup>2</sup>/pulse<sup>2</sup>. This damage manifested itself as a precipitous transmission drop of up to 50% at 157 nm and was accompanied by the formation of a porous rough surface layer about 0.20 &#956;m thick. Understanding this surface damage is important for the durability of laser windows and beam delivery optics, and it may also help elucidate fundamental 157-nm photophysics of fluoride surfaces. To understand the underlying phenomena, we have designed and constructed a new accelerated damage test chamber. The chamber utilizes 157-nm light from a lithography-grade laser operating at 1000 Hz. Inside the chamber, light is focused onto the sample to a submillimeter spot size. The chamber allows us to test in-situ transmission of multiple spots on a given sample over a range of fluences up to 140 mJ/cm<sup>2</sup>/pulse without breaking purge. We have used this chamber to understand the scaling of the damage mechanism for both uncoated and antireflectance (AR) -coated CaF<sub>2</sub> samples as a function of laser repetition rate and fluence. Substrate damage appears to be governed by a complex set of mechanisms, both thermal and non-thermal in origin. Preliminary damage studies of AR-coated substrates show that AR-coating related degradation occurs well before the onset of the substrate surface damage.
Cellular immune factors associated with mother-to-infant transmission of HIV (1993)

Our results demonstrate that fetal T cells can be primed to HIV env determinants in utero, suggest that HIV-specific TH immunity may be protective in newborns, and provide a possible means for identifying newborns who are at risk for HIV infection.
MP60-03 CLINICAL SIGNIFICANCE AND PREDICTORS OF ONCOLOGIC OUTCOME AFTER RADICAL PROSTATECTOMY FOR INVISIBLE PROSTATE CANCER ON MULTIPARAMETRIC MRI (2019)

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV (MP60)1 Apr 2019MP60-03 CLINICAL SIGNIFICANCE AND PREDICTORS OF ONCOLOGIC OUTCOME AFTER RADICAL PROSTATECTOMY FOR INVISIBLE PROSTATE CANCER ON MULTIPARAMETRIC MRI Doo Yong Chung*, Jong Soo Lee, Won Sik Jang, In Rae Cho, Young Sig Kim, Joong Shik Lee, Dong Hoon Lim, Don Gu Lee, Jin Hyung Jeon, and Young deuk Choi Doo Yong Chung*Doo Yong Chung* More articles by this author , Jong Soo LeeJong Soo Lee More articles by this author , Won Sik JangWon Sik Jang More articles by this author , In Rae ChoIn Rae Cho More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Dong Hoon LimDong Hoon Lim More articles by this author , Don Gu LeeDon Gu Lee More articles by this author , Jin Hyung JeonJin Hyung Jeon More articles by this author , and Young deuk ChoiYoung deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556735.07607.d7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail WITHDRAWN Seoul, Korea, Republic of; Gimhae, Korea, Republic of; Goyang, Korea, Republic of; Seoul, Korea, Republic of; Gwangju, Korea, Republic of; Seoul, Korea, Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e869-e869 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Doo Yong Chung* More articles by this author Jong Soo Lee More articles by this author Won Sik Jang More articles by this author In Rae Cho More articles by this author Young Sig Kim More articles by this author Joong Shik Lee More articles by this author Dong Hoon Lim More articles by this author Don Gu Lee More articles by this author Jin Hyung Jeon More articles by this author Young deuk Choi More articles by this author Expand All Advertisement PDF downloadLoading ...
Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study: Table 1 (1996)

Abstract Objective : To study human papillomavirus type 16 in the aetiology of cervical carcinoma. Design : Within a cohort of 18814 Finnish women followed for up to 23 years a nested case-control study was conducted based on serological diagnosis of past infection with human papillomavirus type 16. Subjects : 72 women (27 with invasive carcinoma and 45 with in situ carcinoma) and 143 matched controls were identified during the follow up. Main outcome measure : Relative risk of cervical carcinoma in presence of IgG antibodies to human papillomavirus type 16. Results : After adjustment for smoking and for antibodies to various other agents of sexually transmitted disease, such as herpes simplex virus type 2 and Chlamydia trachomatis, the only significant association was with infection with human papillomavirus type 16 (odds ratio 12.5; 95% confidence interval 2.7 to 57, 2P&lt;0.001). Conclusion : This prospective study provides epidemiological evidence that infection with human papillomavirus type 16 confers an excess risk for subsequent development of cervical carcinoma. Key messages Key messages Human papillomavirus type 16 is the main micro-organism linked to the development of cervical cancer Prospective studies of infection with this virus and cervical cancer have not been reported because of ethical and clinical difficulties and because diagnosis of past infections with the virus has not been possible In this nested case-control study in over 18000 Finnish women who donated blood to a serum bank 25 years ago we were able to measure past infection with human papillomavirus type 16 with new serological tools The results show that infection with the virus confers an increased risk of developing cervical cancer
Supplementary Figure Legends 1-5 from The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines (2023)

Supplementary Figure Legends 1-5 from The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines