gebhart/patrepeval huggingface dataset:
Supp Table 2 from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy (2023)

&lt;p&gt;Differentially expressed genes between NK cells with and without Myc deficiency&lt;/p&gt;
Milligauss magnetic field applied pure water exert firefly luciferin-luciferase luminescence and induce intracellular calcium elevation of CHO cells without ATP (2005)

In the previous paper, we demonstrated that milligauss ultra-low-frequency alternative current (mG ULF-AC) magnetic field applied phosphate buffered saline solution (PBS) per se stimulated elevation of intracellular Ca/sup 2+/ level and enhanced phagocytic activity of human poly-morphonuclear (PMN) leukocyte. During the course of the study to explore the mechanism of the biological effect of such mG magnetic field applied PBS, we found extraordinary phenomena which challenges our understanding of physical chemistry of water and bioenergetics. PBS and highly purified water were exposed to mG ULF-AC which was generated by a Helmholtz coil under visible light (mG/light). When mG/light-applied pure water or PBS was added to the medium, CHO cells which respond to exogenous adenosine triphosphate (ATP) resulting in increase of intracellular Ca/sup 2+/ level, were found to elevate intracellular Ca/sup 2+/ level without exogenous ATP. This activity of mG ULF-AC applied water or PBS was equivalent to 100 nM ATP. Furthermore, when magnetic field was applied on highly purified water under visible light, for more than 12 h at 40/spl deg/C, the pure water became to exert luminescence of luciferin in the presence of luciferase. This reaction did not require ATP nor Mg/sup 2+/ in the reaction mixture at all. These facts indicate that mG/light-applied PBS or water mimics ATP activity.
A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates (2013)

A key strategy to a successful vaccine against malaria is to identify and develop new adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-administration with a rodent malaria vaccine in mice, 7DW8-5, a recently identified novel analog of α-galactosylceramide (α-GalCer), enhances the level of malaria-specific protective immune responses more strongly than the parent compound. In this study, we sought to determine whether 7DW8-5 could provide a similar potent adjuvant effect on a candidate human malaria vaccine in the more relevant non-human primate (NHP) model, prior to committing to clinical development. The candidate human malaria vaccine, AdPfCA (NMRC-M3V-Ad-PfCA), consists of two non-replicating recombinant adenoviral (Ad) vectors, one expressing the circumsporozoite protein (CSP) and another expressing the apical membrane antigen-1 (AMA1) of Plasmodium falciparum. In several phase 1 clinical trials, AdPfCA was well tolerated and demonstrated immunogenicity for both humoral and cell-mediated responses. In the study described herein, 25 rhesus macaques received prime and boost intramuscular (IM) immunizations of AdPfCA alone or with an ascending dose of 7DW8-5. Our results indicate that 7DW8-5 is safe and well-tolerated and provides a significant enhancement (up to 9-fold) in malaria-specific CD8+ T-cell responses after both priming and boosting phases, supporting further clinical development.
Linguistic spatial classifications of event domains in narratives of crime (2010)

Structurally, formal definitions of the linguistic narrative minimally require two temporally linked past-time events. The role of space in this definition, based on spatial language indicating where events occur, is considered optional and non-structural. However, based on narratives with a high frequency of spatial language, recent research has questioned this perspective, suggesting that space is more critical than may be readily apparent. Through an analysis of spatially rich serial criminal narratives, it will be demonstrated that spatial information qualitatively varies relative to narrative events. In particular, statistical classifiers in a supervised machine learning task achieve a 90% accuracy in predicting Pre-Crime, Crime, and Post-Crime events based on spatial (and temporal) information. Overall, these results suggest a deeper spatial organization of discourse, which not only provides practical event resolution possibilities, but also challenges traditional formal linguistic definitions of narrative.
A promising pathway to make multiwalled carbon nanotubes (2000)

Current theories for multiwalled nanotube growth (without metal catalysts) describe the growth of multiwalled nanotubes by the addition of carbon atoms, ions, or small molecules to an open ended nanotube nucleus. In this letter, we describe a method to make carbon nanotubes similar in quality to those found on the cathode deposit of the carbon arc by manipulating the heat treatment of various nongraphitizable carbon precursors. It is proposed that this method of making nanotubes via heat treatments is analogous to a graphitization process, where aromatic/graphitic fragments in disordered carbons assemble into three-dimensional graphitic structures. In addition, we have demonstrated that simple precursors, such as sucrose, can be used as starting materials. These experiments offer new opportunities to understand nanotube growth and could lead to scalable methods to make multiwalled nanotubes.
Oral Administration of Synthetic Retinoid Am80 Inhibits the Development of Type 1 Diabetes in Non-obese Diabetic (NOD) Mice (2009)

Synthetic retinoid Am80 is a potent modulator of the immune system. Am80 is effective in various experimentally induced autoimmune disorders. The purpose of this study is to confirm its effect on non-obese diabetic (NOD) mice, which spontaneously develop autoimmune type 1 diabetes. Am80 was orally administered in feed to 6 NOD mice per group at a dose of 0 (control), 0.1 (low) or 1 (high) mg/kg/d for 19 weeks. During the experiment period, the high urine glucose levels were observed in 33% mice of the control and low Am80 groups, whereas any mouse in the high Am80 group did not show abnormal urine glucose level. Histological examination showed that the average score of insulitis severity in the low Am80 group was similar to that in the control; however in the high Am80 group, the score was significantly reduced compared to that in the control group. Similarly, the severity of lymphocyte infiltration in the submandibular glands showed a tendency to decrease in the high Am80 group, but not in the low Am80 group, compared to the control. These data strongly suggest that the development of type 1 diabetes in NOD mice can be inhibited by oral administration of Am80.
Supplementary Fig S3 from Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer (2023)

&lt;p&gt;- PDF file 57K, Supplemental Figure S3. Kaplan-Meier Curve of Overall Survival Characterized by ADAMTS1 Methylation&lt;/p&gt;
Plane wave imaging using phased array (2014)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Arno Volker; Plane wave imaging using phased array. AIP Conf. Proc. 18 February 2014; 1581 (1): 124–131. https://doi.org/10.1063/1.4864811 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
The Suzuki Reaction Under Solvent-Free Conditions (2000)

Abstract The coupling reaction of diverse arylhalogenids with phenyl-boronic acid under solvent-free conditions has been performed using a palladium catalyst. The order of reactivity was complementary to the normal Suzuki reaction.
New Chemical Entities Entering Phase III Trials in 2015 (2016)

Medicinal Chemistry Reviews is an outstanding 600 page volume providing timely and critical reviews of important topics in medicinal chemistry. It is provided free of charge to MEDI members in electronic format. Members can also order a print copy, for the cost of printing, shipping and handling
X-ray grating interferometer for in situ and at-wavelength wavefront metrology (2016)

A wavefront metrology setup based on the X-ray grating interferometry technique for spatially resolved, quantitative, in situ and at-wavelength measurements of the wavefront at synchrotron radiation and hard X-ray free-electron laser beamlines is reported. Indeed, the ever-increasing demands on the optical components to preserve the wavefront shape and the coherence of the delivered X-ray beam call for more and more sensitive diagnostic instruments. Thanks to its angular sensitivity, X-ray grating interferometry has been established in recent years as an adequate wavefront-sensing technique for quantitatively assessing the quality of the X-ray wavefront under working conditions and hence for the in situ investigation of X-ray optical elements. In order to characterize the optical elements at any given beamline by measuring the aberrations introduced in the wavefront, a transportable X-ray grating interferometry setup was realised at the Swiss Light Source (SLS). The instrument, which is expected to be a valuable tool for investigating the quality of the X-ray beam delivered at an endstation, will be described hereafter in terms of the hardware setup and the related data analysis procedure. Several exemplary experiments performed at the X05DA Optics beamline of the SLS will be presented.
Small-Size X-Band Active Integrated Antenna With Feedback Loop (2008)

A small-sized active integrated antenna (AIA), consisting of a transmission feedback oscillator loaded with a microstrip antenna is presented in this paper. The oscillator antenna, which consists of a NEC super low noise high frequency field effect transistor (HF FET) integrated into the center of a segmented patch antenna, was designed for X-band at 8.50 GHz, and occupies a 5 times 6 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> area. The active integrated antenna demonstrates stable oscillations and excellent radiation patterns at X-band design frequencies. When biased using a single 1.5 volt battery connected between the source and drain and with the gate terminal open, the antenna effective isotropic radiated power (EIRP) and direct current (DC)-to-radiated radio frequency (RF) conversion efficiency are +11.2 dBm and 10.5%, respectively. The radiated power level and directivity are +4.5 dBm and 6.7 dBi, respectively. The phase noise at 100 kHz offset from the carrier is -87.5 dBc/Hz, which is a notable improvement over existing AIA designs. The AIA features compact size and simple geometry, yet provides radiated power levels and radiation efficiencies that are comparable to values typically obtained using circuits that occupy larger areas, and use thicker substrates with much lower dielectric constant values.
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. (2003)

Hypoxia-inducible factor (HIF) plays an important role in determining patterns of gene expression in cancer. HIF is down-regulated in oxygenated cells by a series of Fe (II) and 2-oxoglutarate dependent dioxygenases that hydroxylate specific residues in the regulatory HIF-alpha subunits. Because these enzymes require ascorbate for activity in vitro we analyzed the effects of ascorbate on HIF in human cancer cell lines. Ascorbate at physiological concentrations (25 micro M) strikingly suppressed HIF-1alpha protein levels and HIF transcriptional targets, particularly when the system was oncogenically activated in normoxic cells. Similar results were obtained with iron supplementation. These results indicate that both ascorbate and iron availability have major effects on HIF, and imply that the system is commonly regulated by limiting hydroxylase activity under normoxic tissue culture conditions.
ChemInform Abstract: Anionic (3,3)‐Sigmatropic Rearrangement of N‐Phenyl‐O‐ acylhydroxylamines to o‐Aminophenylacetic Acids. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
40.2: Automotive Display Visibility Considerations (2013)

Abstract The objective of this paper is to formulate methods that can be used to estimate the amount of display luminance required based on: Display geometry conditions Display reflection components
Using Image Quality Metrics to Evaluate an ICC Printer Profile (2010)

The increased interest in color management has resulted in more options for the user to choose between for their color management needs. Evaluating the quality of each of these color management packages is a challenging and time-consuming task. We propose an evaluation using image quality metrics to assess the quality of a printer profile. This will determine the best solution for a given set of objectives. The goal of this work is to create a thorough evaluation for a printer profile to determine the most appropriate profile without using observers.A printer profile has several aspects that can be evaluated separately: colorimetric accuracy, invertibility, grayscale reproduction, perceptual image quality, smoothness and gamut mapping. In this paper we look for a solution for applying image quality metrics to evaluate the different aspects of ICC printer profiles. The aim of this research is to reduce the amount of time required to compare the overall quality of ICC profiles and give a more thorough evaluation than is typically done by subjectively evaluating each aspect of the printer profile individually.
Ionic Melt Electroltyes for Lithium Battery Applictions (2007)

Ionic melt electrolytes consisting of lithium salts of fluorosulfonamide anions covalently attached to oligomeric polyether chains were synthesized and characterized with respect to structure and ion transport characteristics. Conductivity data are reported for melts of variable ether- oxygen-to-lithium ratio, and for melts having different amounts of polyether plasticizers added. Conductivities are generally high relative to true polymer electrolytes.
A Circuit Model for the Design of Self-Excited EBG Resonator Antennas With Miniaturized Unit Cells (2014)

A circuit model based on Bloch theory is introduced to simplify analysis and design of antennas composed of thick metal electromagnetic band-gap (EBG) cells with large intercell coupling capacitance. The cells are composed of thick metal patches periodically deployed on a metal-backed dielectric slab. Two versions of cells are presented that provide large intercell capacitance, one with narrow high aspect ratio (HAR) gaps between cells and the other with interdigitated gaps between cells. This large capacitance reduces the antenna resonance and dramatically miniaturizes the EBG cells. Three cascaded unit cells are used to demonstrate the applicability of the circuit model to characterize the recently introduced self-excited EBG resonator antenna. Full-wave numerical analysis and experimentation validate the robustness and accuracy of the model over large variations in electrical/physical cell dimensions.
Enhancing the PLA crystallization rate by incorporating a polystyrene‐block‐poly(methyl methacrylate) block copolymer: Synergy of polystyrene and poly(methyl methacrylate) segments (2014)

ABSTRACT A polystyrene‐ block ‐poly(methyl methacrylate) (PS‐ b ‐PMMA) exhibiting a well‐defined structure was prepared combining anionic polymerization and mercaptan/ε‐caprolactam living polymerization. To evaluate how this block copolymer affected the crystallization of polylactide (PLA), 0.5 wt % thiol‐terminated PS homopolymer (PSSH), PMMA, and PS‐ b ‐PMMA was melt‐blended with PLA. The calorimetric characterization of the nonisothermal and isothermal crystallization behavior was analyzed according to Avrami's theory, indicating that PS‐ b ‐PMMA more effectively increased the crystallization kinetics of the PLA matrix than did PSSH or PMMA. The results revealed that the synergistic effect of the PS and PMMA blocks appeared only when they were simultaneously presented in the PLA matrix. The PS block increased the number of nucleation sites and decreased the spherulite size, whereas the PMMA block facilitated the excellent dispersion of PS‐ b ‐PMMA in the PLA matrix as shown in polarizing optical microscope experiments. Incorporating PS‐ b ‐PMMA improved the PLA crystallization rate by promoting heterogeneous nucleation. In addition, incorporating 0.5 wt % PS‐ b ‐PMMA increased the relative crystallinity of PLA to 43.5%, and decreased the crystallization half‐time to 2.4 min when the blend was isothermal at 105 °C. The PLA crystal structure was unchanged by the presence of PS‐ b ‐PMMA; however, the crystallization rate was enhanced as probed by SEM and X‐ray diffraction. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2014 , 52 , 823–832
Sensitivity ofStaphylococcus aureusStrains to Broadband Visible Light (2008)

The phototoxic effect of illumination with broadband visible light on the viability of two Staphylococcus aureus strains was examined in the present study. A difference in the light sensitivity of the two strains was found. Illumination of the tested strains with a fluence rate of 180 J cm(-2) caused a reduction of up to 99.8% in the colony count of one of the strains (the "sensitive" strain). Illumination of the other strain (the "resistant" strain) resulted in a 55.5% reduction in viability. Proliferation of both strains was observed at low fluence rates of light. The phototoxic effect was found to be dependent on oxy radical production. The light-sensitive strain produced higher amounts of hydroxyl and superoxide radicals than the "resistant" strain. Adaptation to oxidative stress was exhibited only by the "resistant" strain. The "sensitive" strain produced ten times more endogenous porphyrins and secreted almost nine times more porphyrins than the resistant strain. Furthermore, the "resistant" strain produced twice as many carotenoids that protect the strain from illumination than the "sensitive" strain. These results indicate that high intensities of visible light cause bacterial photoeradication, a reaction which may assist wound healing by killing the infecting bacteria. On the other hand, low intensities of white light were found to enhance bacterial proliferation and thus prolong wound infection.
Forward-central two-particle correlations in p–Pb collisions at sNN=5.02 TeV (2015)

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 < || < 4.0) and associated particles in the central range (|| < 1.0) are measured with the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The trigger particles are reconstructed using the muon spectrometer, and the associated particles by the central barrel tracking detectors. In high-multiplicity events, the double-ridge structure, previously discovered in two-particle angular correlations at midrapidity, is found to persist to the pseudorapidity ranges studied in this Letter. The second-order Fourier coefficients for muons in high-multiplicity events are extracted after jet-like correlations from low-multiplicity events have been subtracted. The coefficients are found to have a similar transverse momentum (p T ) dependence in p-going (p-Pb) and Pb-going (Pb-p) configurations, with the Pb-going coefficients larger by about 16 6%, rather independent of p T within the uncertainties of the measurement. The data are compared with calculations using the AMPT model, which predicts a different p T and dependence than observed in the data. The results are sensitive to the parent particle v 2 and composition of reconstructed muon tracks, where the contribution from heavy flavour decays is expected to dominate at p T > 2 GeV/c.
Design of Simulated Server Racks for Data Center Research (2011)

Conducting experiments on real high-density computer servers can be an expensive and risky task due to the risks associated with unintended inlet temperatures that exceed the server’s red-line temperature limit. Presented herein is the development of the simulated chassis that mimic real computer servers. Briefly, twelve high-power simulated chassis were designed and built to accurately simulate the actual operating conditions of a real computer chassis in a data center. Each simulated chassis is designed to have approximately 300 Pa pressure drop at a flow rate of 600 cfm to represent a real IBM server chassis. Additionally, the simulated chassis are designed to match the thermal mass of a real server. Eight of the simulated chassis were designed to have constant speed fans and variable heating power while the remaining four chassis were designed to have variable speed fans and variable heating power. Further discussions about the design phase of the simulated chassis are the substantial part of this paper. Underlining the challenges and safety issues with high-power chassis, guidelines for designing and constructing a chassis that simulates the real environment of a typical data center are presented.
One-pod preparation of anodic porous alumina molds with tapered holes for moth-eye structures by nanoimprinting (2019)

Abstract An anodic porous alumina mold with tapered holes was formed by a one-pod preparation process. In this process, one-pod of a mixed solution containing oxalic acid and phosphoric acid was used for both anodization and pore widening. The anodization proceeded during the on state of the applied voltage, while the pore widening proceeded during the off state. The shape of the tapered holes in anodic porous alumina could be controlled by adjusting the program composed of on and off periods. Moth-eye structures were formed by nanoimprinting using the obtained molds. These moth-eye structures effectively suppressed the reflection of incident light.
Acute Myocardial Infarction: Safety of Cardiac MR Imaging after Percutaneous Revascularization with Stents (2006)

Cardiac MR imaging performed shortly after AMI and percutaneous revascularization with bare metal or drug-eluting stents appears safe. The risk of adverse cardiovascular events is low and similar to that in patients who do not undergo MR imaging.
<title>Neural networks for mobile robot visual exploration</title> (1993)

This work describes the implementation of some of the neural systems that will enable a mobile robot to actively explore and learn its environment visually. These systems perform the real-time extraction of robust visual features, the segmentation of landmarks from the background and from each other using binocular attentional mechanisms, the predictive binocular tracking of landmarks, and the learning and recognition of landmarks from their features. Also described are preliminary results of incorporating most of these systems into a mobile robot called MAVIN, which can demonstrate the visual exploration of simplified landmarks. Finally, we discuss plans for using similar neural strategies to extend MAVIN's capabilities by implementing a biologically plausible system for navigating through an environment that has been learned by exploration. This explorational learning consists of quantizing the environment into orientation-specific place fields generated by the view-based spatial distribution of landmarks, and associating these place fields in order to form qualitative, behavioral, spatial maps.