gebhart/patrepeval huggingface dataset:
Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration (2023)

Minimally invasive biodegradable implants with regeneration have been a frontier trend in clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and traditional spinal fusion or discectomy usually injure adjacent segments. Here, an innovative minimally invasive biodegradable NP scaffold with function regeneration inspired by cucumber tendril is developed using shape memory polymer poly(glycerol-dodecanoate) (PGD), whose mechanical property is controlled to the similar with human NP by adjusting synthetic parameters. The chemokine stromal cell-derived factor-1α (SDF-1α) is immobilized to the scaffold recruiting autologous stem cells from peripheral tissue, which has better ability of maintaining disc height, recruiting autologous stem cells, and inducing regeneration of NP in vivo compared to PGD without chemokine group and hydrogel groups significantly. It provides an innovative way to design minimally invasive implants with biodegradation and functional recovery, especially for irreversible tissue injury, including NP, cartilage and so on.
Design of cascaded diffractive phase elements for three-dimensional multiwavelength optical interconnects (2000)

We propose a novel design method that incorporates multiple-layer relief profiles of diffractive phase elements to implement integrated operations on the incident beams according to their wavelengths. We demonstrate simultaneous wavelength-division demultiplexing, arbitrary (even random) wavelength shuffling or routing, spatial focusing, and other manipulations of multiwavelength beams, such as irradiance profile shaping, with design examples for applications in three-dimensional optical interconnects.
Swelling of Ultrathin Molecular Layer‐by‐Layer Polyamide Water Desalination Membranes (2013)

ABSTRACT The water vapor swelling behavior of ultrathin crosslinked aromatic polyamide (PA) films, synthesized via molecular layer‐by‐layer deposition, is characterized via specular X‐ray reflectivity. The results show that these films expand only along the thickness direction and their maximum swelling ratio can be controlled by the specific diamine monomer chemistry. By measuring the swelling ratio as a function of water activity, the Flory interaction parameter and monomers between crosslinks of these PAs are characterized using the Flory‐Rehner and the Painter‐Shenoy thermodynamic swelling models. Comparing the monomers between crosslink calculated from the swelling theories with values obtain from chemical analysis indicate that the PS model gives a more accurate description of the PA networks. This suggests that these low functionality but highly crosslinked networks swell via a combination of chain expansion and topological rearrangement. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013 , 51 , 1647–1655
Volume IV. The DUNE far detector single-phase technology (2020)

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. Central to achieving DUNE's physics program is a far detector that combines the many tens-of-kiloton fiducial mass necessary for rare event searches with sub-centimeter spatial resolution in its ability to image those events, allowing identification of the physics signatures among the numerous backgrounds. In the single-phase liquid argon time-projection chamber (LArTPC) technology, ionization charges drift horizontally in the liquid argon under the influence of an electric field towards a vertical anode, where they are read out with fine granularity. A photon detection system supplements the TPC, directly enhancing physics capabilities for all three DUNE physics drivers and opening up prospects for further physics explorations. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume IV presents an overview of the basic operating principles of a single-phase LArTPC, followed by a description of the DUNE implementation. Each of the subsystems is described in detail, connecting the high-level design requirements and decisions to the overriding physics goals of DUNE.
Oleochemistry meets supramolecular chemistry: the self-healing elastomer (2011)

International audience
Carrier trapping and efficient recombination of electrophosphorescent device with stepwise doping profile (2005)

We have presented a physical concept for enhancing efficiency and lifetime of doped electrophosphorescent organic light-emitting devices. In order to provide a control parameter for higher device performance, a stepwise doping concentration profile at the emission layer was prepared. A more than 30% improvement of power efficiency was obtained for green electrophosphorescent device with a higher doping ratio at the emission layer-hole transport layer interface. We explained the carrier trapping and transport mechanism with direct recombination of an exciton in an iridium-based dopant system. When compared to green device, phosphorescent red devices showed a more significant charge trapping effect at low doping concentration, which is responsible for shifting the recombination zone far from the emission layer-hole transport layer interface. Therefore, charge trapping by doping control in an emission layer could be utilized for a charge-balancing technique for the confinement of a triplet exciton.
Both high-dose (4.8g/day) induction and low-dose (2.4g/day) maintenance therapy with MMXTM mesalamine have an excellent safety profile in patients with mild-to-moderate ulcerative colitis (2008)

To determine the safety and tolerability of high-dose induction and lowdose maintenance therapy with MMX mesalamine (LialdaTM [MezavantTM XL, UK and Ireland; Mezavant,TM elsewhere]), a novel, oral formulation of 5-ASA designed for oncedaily (QD) dosing in patients with mild-to-moderate ulcerative colitis (UC). In two phase III, placebo-controlled, 8-week trials (SPD476-301 and -302) MMX mesalamine 2.4g/day was well tolerated for the induction of clinical and endoscopic remission (defined as a modified UC Disease Activity Index score of ≤1, calculated as: scores of 0 for rectal bleeding and for stool frequency; a combined Physician's Global Assessment and sigmoidoscopy score of ≤1; no mucosal friability; and a sigmoidoscopy score reduction of ≥1 point from baseline) in patients with active, mildto-moderate UC. Patients in remission after study 301 or study 302 could enter a randomized, 12-month maintenance study (SPD476-303) in which they received MMX mesalamine 2.4g/day (QD or 1.2g twice daily [BID]). Patients who did not achieve remission in the parent studies could opt to receive an additional 8 weeks' open-label, high-dose, MMX mesalamine therapy (4.8g/day [2.4g BID]) as part of study 303. Patients in remission after this 8-week extension study could also enter the 12-month maintenance study. Here we present the 8-week extension and 12-month maintenance study safety data. The 8-week extension and maintenance study safety population consisted of 312 and 459 patients, respectively. The table summarises the proportion of patients with adverse events (AEs). The most common AEs in both studies were gastrointestinal disorders (8.3 and 17.2% of patients in the 8-week extension phase and the 12-month maintenance phase, respectively). The majority of AEs were mild in intensity in both studies and were similar to those reported for other 5-ASA formulations. Two patients died: suicide (8-week extension study), and accidental electric shock (maintenance study). Two serious AEs were deemed possibly or probably related to study medication: pancreatitis (one patient in the 8-week extension study, who had received placebo during one of the parent studies) and abnormal liver function tests (one patient on 2.4g/day [QD] in the maintenance study). Both high-dose (4.8g/day) induction therapy and low-dose (2.4g/day) maintenance therapy with MMX mesalamine are well tolerated in patients with mildto-moderate UC.
Carbon Dioxide Capture at Nucleophilic Hydroxide Sites in Oxidation‐Resistant Cyclodextrin‐Based Metal–Organic Frameworks** (2022)

Carbon capture and sequestration (CCS) from industrial point sources and direct air capture are necessary to combat global climate change. A particular challenge faced by amine-based sorbents-the current leading technology-is poor stability towards O<sub>2</sub> . Here, we demonstrate that CO<sub>2</sub> chemisorption in γ-cylodextrin-based metal-organic frameworks (CD-MOFs) occurs via HCO<sub>3</sub> <sup>-</sup> formation at nucleophilic OH<sup>-</sup> sites within the framework pores, rather than via previously proposed pathways. The new framework KHCO<sub>3</sub> CD-MOF possesses rapid and high-capacity CO<sub>2</sub> uptake, good thermal, oxidative, and cycling stabilities, and selective CO<sub>2</sub> capture under mixed gas conditions. Because of its low cost and performance under realistic conditions, KHCO<sub>3</sub> CD-MOF is a promising new platform for CCS. More broadly, our work demonstrates that the encapsulation of reactive OH<sup>-</sup> sites within a porous framework represents a potentially general strategy for the design of oxidation-resistant adsorbents for CO<sub>2</sub> capture.
Topologically spherical molecules. Rearrangement reactions of functionalized C2-symmetric hexaquinane systems and synthesis of (C2)-dioxa-C20-octaquinane, a heterocyclic trisecododecahedrane (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTopologically spherical molecules. Rearrangement reactions of functionalized C2-symmetric hexaquinane systems and synthesis of (C2)-dioxa-C20-octaquinane, a heterocyclic trisecododecahedraneLeo A. Paquette, William J. Begley, Douglas Balogh, Matthew J. Wyvratt, and David BremnerCite this: J. Org. Chem. 1979, 44, 21, 3630–3638Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/jo01335a004https://doi.org/10.1021/jo01335a004research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of Carbonic Anhydrase I in Motor Neurons and Alterations in ALS (2016)

Carbonic anhydrase I (CA1) is the cytosolic isoform of mammalian α-CA family members which are responsible for maintaining pH homeostasis in the physiology and pathology of organisms. A subset of CA isoforms are known to be expressed and function in the central nervous system (CNS). CA1 has not been extensively characterized in the CNS. In this study, we demonstrate that CA1 is expressed in the motor neurons in human spinal cord. Unexpectedly, a subpopulation of CA1 appears to be associated with endoplasmic reticulum (ER) membranes. In addition, the membrane-associated CA1s are preferentially upregulated in amyotrophic lateral sclerosis (ALS) and exhibit altered distribution in motor neurons. Furthermore, long-term expression of CA1 in mammalian cells activates apoptosis. Our results suggest a previously unknown role for CA1 function in the CNS and its potential involvement in motor neuron degeneration in ALS.
Relationship between Gas Sensitivity and Microstructure of Porous SnO<sub>2</sub> (1990)

The influences of SnO2crystallite size(D)on gas sensing prQperties were investigated by using ultrane particles in the range of4-27nmIt was fbund that the dependence of electric resistance on D was divided into two regionswhich allowe(l to estimate Debye length (L)tobe ca3nmThe gas sensitivity to H2and CO increased steeply asDdecrease(1below10 nmand achieved high values at ca5nm ofDThe analysis ofsuch behavior shows that the gas sensitivity is governed primarily by necks fbr crystallites having P near2Lwhile it is by grain boundaries)r D considerably longer than2L 11NTRODUCTlON Tin oxide gas sensors detect reducing gases from a change in electric resistance of the ele-mentsIt is generally accepted that the chemi sorption of oxygen on the surface of SnO2particles creates a high electric resistance layer to a depth of Debye length(L)Consumption of the chemisorbed oxygen by reducing gases results in adecrease in resistanceThe Hall efctmeasurement by Ogawa et aL1)has revealed that L for a porous thin film ofSnO2is as small as ca3nm at 300COn the other handthe crystallite size(jD)
Root-Polynomial Color Homography Color Correction (2017)

Homographies are at the heart of computer vision and they are used in geometric camera calibration, image registration, and stereo vision and other tasks. In geometric computer vision, two images of the same 3D plane captured in two different viewing locations are related by a planar (2D) homography. Recent work showed that the concept of a planar homography mapping can be applied to shading-invariant color correction. In this paper, we extend the color homography color correction idea by incorporating higher order root-polynomial terms into the color correction problem formulation. Our experiments show that our new shading-invariant color correction method can obtain yet more accurate and stable performance compared with the previous 2D color homography method.
Iontronic analog of synaptic plasticity: Hydrogel-based ionic diode with chemical precipitation and dissolution (2022)

In this study, an aqueous nonlinear synaptic element showing plasticity behavior is developed, which is based on the chemical processes in an ionic diode. The device is simple, fully ionic, and easily configurable, requiring only two terminals-for input and output-similar to biological synapses. The key processes realizing the plasticity features are chemical precipitation and dissolution, which occur at forward- or reverse-biased ionic diode junctions in appropriate reservoir electrolytes. Given that the precipitate acts as a physical barrier in the circuit, the above processes change the diode conductivity, which can be interpreted as adjusting "synaptic weight" of the system. By varying the operating conditions, we first demonstrate the four types of plasticity that can be found in biological system: long-term potentiation/depression and short-term potentiation/depression. The plasticity of the proposed iontronic device has characteristics similar to those of neural synapses. To demonstrate its potential use in comparatively complex information processing, we develop a precipitation-based iontronic synapse (PIS) capable of both potentiation and depression. Finally, we show that the postsynaptic signals from the multiple excitatory or inhibitory PISs can be integrated into the total "dendritic" current, which is a function of time and input history, as in actual hippocampal neural circuits.
Vacuum ultraviolet photoelectron spectroscopy of (NH4)2S-treated GaAs (100) surfaces (1989)

The surface chemistry and band bending of the ammonium sulfide-treated GaAs (100) surface has been studied using surface-sensitive synchrotron radiation photoemission spectroscopy. We find that the treatment leaves the GaAs surface terminated with roughly a monolayer of sulfur bonded to both As and Ga atoms. An n-type barrier height of 0.8 eV is measured. The thermal stability of the various chemical components is studied and various issues of the passivating mechanism are discussed.
Front Cover: Macromol. Rapid Commun. 17/2006 (2006)

Front Cover: A block copolymer/homopolymer (AB/hA) blend exhibits coexisting bicontinuous morphologies, one ordered and the other disordered. Transmission electron microtomography is used to analyze the 3D features of both morphologies (right images), and complementary Mesodyn simulations identify the distributions of hA, A and B within the morphologies (lower images). Further details can be found in the article by H. Jinnai, H. Hasegawa, * Y. Nishikawa, G. J. A. Sevink, M. B. Braunfeld, D. A. Agard, and R. J. Spontak * on page 1424.
Updates in therapy for uterine serous carcinoma (2012)

There is an expanding role for contemporary novel approaches in the treatment of USC. The results of clinical investigations using new target antigens, epothilones, and small molecule inhibitors are eagerly awaited.
From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells (2009)

Recent studies have demonstrated that glycogen synthase kinase 3beta (GSK-3beta) is overexpressed in human colon and pancreatic carcinomas, contributing to cancer cell proliferation and survival. Here, we report the design, synthesis, and biological evaluation of benzofuran-3-yl-(indol-3-yl)maleimides, potent GSK-3beta inhibitors. Some of these compounds show picomolar inhibitory activity toward GSK-3beta and an enhanced selectivity against cyclin-dependent kinase 2 (CDK-2). Selected GSK-3beta inhibitors were tested in the pancreatic cancer cell lines MiaPaCa-2, BXPC-3, and HupT3. We determined that some of these compounds, namely compounds 5, 6, 11, 20, and 26, demonstrate antiproliferative activity against some or all of the pancreatic cancer cells at low micromolar to nanomolar concentrations. We found that the treatment of pancreatic cancer cells with GSK-3beta inhibitors 5 and 26 resulted in suppression of GSK-3beta activity and a distinct decrease of the X-linked inhibitor of apoptosis (XIAP) expression, leading to significant apoptosis. The present data suggest a possible role for GSK-3beta inhibitors in cancer therapy, in addition to their more prominent applications in CNS disorders.
HSR22-167: Burden of Myelosuppression Among Patients With Extensive-Stage Small Cell Lung Cancer Treated With Chemotherapy in a Community Oncology Setting (2022)

"HSR22-167: Burden of Myelosuppression Among Patients With Extensive-Stage Small Cell Lung Cancer Treated With Chemotherapy in a Community Oncology Setting" published on 31 Mar 2022 by National Comprehensive Cancer Network.
Topology optimization of multiscale structures considering local and global buckling response (2023)

Much work has been done in topology optimization of multiscale structures for maximum stiffness or minimum compliance design. Such approaches date back to the original homogenization-based work by Bendsøe and Kikuchi from 1988, which lately has been revived due to advances in manufacturing methods like additive manufacturing. Orthotropic microstructures locally oriented in principal stress directions provide for highly efficient stiffness optimal designs, whereas for the pure stiffness objective, porous isotropic microstructures are sub-optimal and hence not useful. It has, however, been postulated and exemplified that isotropic microstructures (infill) may enhance structural buckling stability but this has yet to be directly proven and optimized. In this work, we optimize buckling stability of multiscale structures with isotropic porous infill. To do this, we establish local density dependent Willam–Warnke yield surfaces based on local buckling estimates from Bloch–Floquet-based cell analysis to predict local instability of the homogenized materials. These local buckling-based stress constraints are combined with a global buckling criterion to obtain topology optimized designs that take both local and global buckling stability into account. De-homogenized structures with small and large cell sizes confirm validity of the approach and demonstrate huge structural gains as well as time savings compared to standard singlescale approaches.
Rapid Molecular Microbiologic Diagnosis of Prosthetic Joint Infection (2013)

We previously showed that culture of samples obtained by prosthesis vortexing and sonication was more sensitive than tissue culture for prosthetic joint infection (PJI) diagnosis. Despite improved sensitivity, culture-negative cases remained; furthermore, culture has a long turnaround time. We designed a genus-/group-specific rapid PCR assay panel targeting PJI bacteria and applied it to samples obtained by vortexing and sonicating explanted hip and knee prostheses, and we compared the results to those with sonicate fluid and periprosthetic tissue culture obtained at revision or resection arthroplasty. We studied 434 subjects with knee (n = 272) or hip (n = 162) prostheses; using a standardized definition, 144 had PJI. Sensitivities of tissue culture, of sonicate fluid culture, and of PCR were 70.1, 72.9, and 77.1%, respectively. Specificities were 97.9, 98.3, and 97.9%, respectively. Sonicate fluid PCR was more sensitive than tissue culture (P = 0.04). PCR of prosthesis sonication samples is more sensitive than tissue culture for the microbiologic diagnosis of prosthetic hip and knee infection and provides same-day PJI diagnosis with definition of microbiology. The high assay specificity suggests that typical PJI bacteria may not cause aseptic implant failure.
Dynamic Scheduling on Heterogeneous Multicores (2019)

Heterogeneous multicore systems help meet design goals by using disparate hardware components that are suitable for different application requirements/design goals. The individual cores may also have different tunable hardware parameters for additional specialization. However, this complicates scheduling since to reap the benefits of specialization, applications should be scheduled to the core that offers the best configuration based on the application's requirements and design goals. This scheduling decision could be made by exploring the design space to evaluate different configurations to determine the best configuration, or by executing the application in a base configuration to gather execution statistics to predict the best configuration. However, given increasingly complex systems, these methods may be infeasible given extremely large design spaces or difficulty in choosing a representative base configuration. In this paper, we present a dynamic scheduling methodology that uses predictive methods to schedule applications to best configurations for reduced energy consumption for a system with configurable caches. We use an artificial neural network (ANN) to train our predictive model using hardware counters. The trained ANN can then be used to predict the best core and a tuning heuristic explores the design space to determine the best configuration on non-best cores. If the best core is busy, our scheduler considers alternative idle cores or the application is stalled depending on which decision is energy advantageous. Our experiments show that system energy can be reduced by 28% on average as compared to a fixed-core system where all cores offer the same configuration.