gebhart/patrepeval huggingface dataset:
A simple approach to a new T8-POSS based MRI contrast agent (2016)

A fast and simple route was developed to synthesize a new T<sub>8</sub>-silsesquioxane based contrast agent for potential application in Magnetic Resonance Imaging. For this purpose the novel C<sub>2</sub>-thiol-functionalized T<sub>8</sub>-silsesquioxane (3) was constructed as a carrier molecule as well as the DOTA based gadolinium(iii) complex (11) equipped with allyl terminated linkers was prepared. The linkage of the complexes to the T<sub>8</sub>-silsesquioxane was performed via an UV-light catalyzed thiol-ene click reaction within one hour which affords the desired product 13 in a yield of 80%. The successful transformation as well as the intactness of the cube was confirmed by spectroscopic methods and mass spectrometry. This new and simple approach offers a highly effective access to T<sub>8</sub>-silsesquioxanes functionalized with eight metal complexes. Longitudinal relaxivity measurements of compound 13 (9.5 ± 0.9 mM<sup>-1</sup> s<sup>-1</sup>) at 3 T in HEPES buffered cell culture medium (physiological conditions) show a significant enhancement of r<sub>1</sub> per 1 mM gadolinium in comparison to the clinically applied contrast agent Dotarem™ (3.4 mM<sup>-1</sup> s<sup>-1</sup>). In relation to the former reported T<sub>8</sub>-silsesquioxane based contrast agent Gadoxane G (10.6 mM<sup>-1</sup> s<sup>-1</sup>) a similar relaxivity is found. As the T<sub>8</sub>-core of polyhedral oligosilsesquioxanes (POSS) based contrast agents undergoes a hydrolysis process depending on the pH, long-term r<sub>1</sub> measurements in different solutions (water, cell culture medium and HEPES buffered medium) as well as <sup>1</sup>H, <sup>1</sup>H/<sup>29</sup>Si HSQC and PGSE diffusion <sup>1</sup>H NMR spectroscopic investigations on aqueous solutions were performed. In solutions featuring an approximately neutral pH (D<sub>2</sub>O, pD = 7.0; water and HEPES buffered medium, pH = 7.4-7.5) contrast agent 13 (t<sub>1/2</sub> = 2.4 d, HEPES/medium) shows a slower decomposition of the T<sub>8</sub>-cage in comparison to the previously synthesized Gadoxane G (t<sub>1/2</sub> = 15 ± 3 h, HEPES/medium). However, under more basic conditions (medium, pH = 8.4-8.5) the decomposition process of 13 is considerably accelerated (t<sub>1/2</sub> ∼ 55-60 min), indicating a higher sensitivity of the T<sub>8</sub>-cage to pH shifts into the basic range similar to Gadoxane G.
Methods for Insulin Bolus Adjustment Based on the Continuous Glucose Monitoring Trend Arrows in Type 1 Diabetes: Performance and Safety Assessment in an In Silico Clinical Trial (2021)

Insulin bolus adjustment methods are effective for negative ROCs, but they generally appear to overdose for positive ROCs, calling for safer strategies in such a scenario. These results can be useful in outlining guidelines to identify which adjustment to apply based on the mealtime condition.
Modeling and Characterization of Nitrogen-Enhanced Negative-Bias Temperature Instability in p-Channel MOSFETs (2007)

Negative-bias temperature instability (NBTI) of nitrided gate oxides prepared with different nitridation processes was characterized and the NBTI results can be well described by an analytical reaction-dispersive-diffusion model in the diffusion-limited regime. The activation energies were recalculated by eliminating the non-Arrhenius part, and this confirms that both the interfacial nitrogen concentration and the nitrogen depth profile in the nitrided oxides play important roles in the nitrogen-enhanced NBTI. Furthermore, first-principles calculations were carried out to examine the effects of nitrogen as either the reaction site or the neighboring atoms at the interface. Lower reaction energies due to the incorporation of nitrogen suggest that nitrogen is a more effective hydrogen-originated hole-trapping center than oxygen and hence enhances NBTI. It was also found that hydrogen-originated hole trapping at vacancy defects has the strongest dependence on the nitrogen neighboring effect. Moreover, the role of nitrogen in NBTI was also investigated in terms of its influence on the electronegativity and atomic-charge distribution.
787: Predicting The 10-Year Probability of Prostate Cancer Recurrence: An Updated Postoperative Nomogram and a Suite of Nomograms for Patients who are Free of Disease at One to Five Years after Radical Prostatectomy (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 8:00am - 12:00 pm1 Apr 2004787: Predicting The 10-Year Probability of Prostate Cancer Recurrence: An Updated Postoperative Nomogram and a Suite of Nomograms for Patients who are Free of Disease at One to Five Years after Radical Prostatectomy Andrew J. Stephenson, Christopher J. Di Blasio, James A. Eastham, Peter T. Scardino, and Michael W. Kattan Andrew J. StephensonAndrew J. Stephenson More articles by this author , Christopher J. Di BlasioChristopher J. Di Blasio More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , and Michael W. KattanMichael W. Kattan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38036-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "787: Predicting The 10-Year Probability of Prostate Cancer Recurrence: An Updated Postoperative Nomogram and a Suite of Nomograms for Patients who are Free of Disease at One to Five Years after Radical Prostatectomy." The Journal of Urology, 171(4S), pp. 208–209 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 208-209 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Andrew J. Stephenson More articles by this author Christopher J. Di Blasio More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Michael W. Kattan More articles by this author Expand All Advertisement PDF DownloadLoading ...
RANTES-Induced T Cell Activation Correlates with CD3 Expression (1998)

The chemokine RANTES induces a unique biphasic cytoplasmic Ca2+ signal in T cells. The first phase of this signal, similar to that of other chemokines, is G-protein mediated and chemotaxis associated. The second phase of this signal, unique to RANTES and evident at concentrations greater than 100 nM, is tyrosine kinase linked and results in a spectrum of responses similar to those seen with antigenic stimulation of T cells. We show here that certain jurkat T cells responded to RANTES solely through this latter pathway. A direct correlation between the RANTES-induced second phase response and CD3 expression was demonstrated in these cells. Sorting the Jurkat cells into CD3(high) and CD3(low) populations revealed that only the CD3(high) cells were responsive to RANTES. Furthermore, stimulation of these Jurkat cells with anti-CD3 mAb significantly depresses their subsequent response to RANTES. While a RANTES-specific chemokine receptor is expressed at a low level on these Jurkat cells, the RANTES-induced activation is dependent on the presence of the TCR. Thus, stimulation through TCR may partially account for RANTES' unique pattern of signaling in T cells.
Biomechanics of Bone and Tissue: A Review of Material Properties and Failure Characteristics (1986)

&lt;div class="htmlview paragraph"&gt;This paper contains a review of current information on biological structure, material properties and failure characteristics of bone, articular cartilage, ligament and tendon. The load-deformation response of biological tissues is presented with particular reference to the microstructure of the material. Although many of the tissues have been characterized as linear, elastic and isotropic materials, they actually have a more complicated response to load, which includes stiffening with increasing strain, inelastic yield, and strain rate sensitivity. Failure of compact and cancellous bone depends on the rate, type, and direction of loading. Soft biological tissues are vlscoelastie and exhibit a higher load tolerance with an increasing rate of loading. The paper includes a discussion on the basic principles of biomechanics and emphasizes material properties and failure characteristics of biological tissues subjected to impact loading.&lt;/div&gt;
Fiber diameter and seeding density influence chondrogenic differentiation of mesenchymal stem cells seeded on electrospun poly(ε-caprolactone) scaffolds (2015)

Chondrogenic differentiation of mesenchymal stem cells is strongly influenced by the surrounding chemical and structural milieu. Since the majority of the native cartilage extracellular matrix is composed of nanofibrous collagen fibrils, much of recent cartilage tissue engineering research has focused on developing and utilizing scaffolds with similar nanoscale architecture. However, current literature lacks consensus regarding ideal fiber diameter, with differences in culture conditions making it difficult to compare between studies. Here, we aimed to develop a more thorough understanding of how cell-cell and cell-biomaterial interactions drive in vitro chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs). Electrospun poly(ε-caprolactone) microfibers (4.3±0.8μm diameter, 90 μm(2) pore size) and nanofibers (440±20 nm diameter, 1.2 μm(2) pore size), were seeded with MSCs at initial densities ranging from 1×10(5) to 4×10(6) cells/cm(3)-scaffold and cultured under transforming growth factor-β (TGF-β) induced chondrogenic conditions for 3 or 6 weeks. Chondrogenic gene expression, cellular proliferation, as well as sulfated glycosaminoglycan and collagen production was enhanced on microfiber in comparison to nanofiber scaffolds, with high initial seeding densities being required for significant chondrogenic differentiation and extracellular matrix deposition. Both cell-cell and cell-material interactions appear to play important roles in chondrogenic differentiation of MSCs in vitro and consideration of several variables simultaneously is essential for understanding cell behavior in order to develop an optimal tissue engineering strategy.
Supplementary Figures 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set (2023)

Supplementary Figures 1-4 from Integrative Analysis of Proteomic Signatures, Mutations, and Drug Responsiveness in the NCI 60 Cancer Cell Line Set
Experimental Strategies for the Identification of DNA-Binding Proteins (2011)

This article describes approaches for identifying proteins that bind conserved or functional DNA motifs. It discusses the use of consensus sequence databases to identify candidate proteins capable of binding a DNA motif of interest and then explains the potential uses of sophisticated mass spectrometry technology. DNA-binding proteins are most commonly identified by electrophoretic mobility-shift assay (EMSA) or DNase I footprinting. Each of these methods is described, and their advantages and limitations are outlined. It is important to stress that each of the strategies discussed in this article may identify one or more proteins that bind a DNA element of interest. However, none of the strategies will necessarily lead to the protein that is the functionally relevant regulator of the control element in the context of the endogenous locus. Regardless of how a DNA-binding protein is isolated and identified, it merely becomes a candidate regulator of the gene of interest.
Reproductive tract infections in rural women from the highlands, jungle, and coastal regions of Peru. (2004)

Overall, 77% of women had symptoms indicative of RTIs, and 70% had objective evidence of one or more RTIs. Women with selected symptoms and signs of vaginal infection could benefit from standard metronidazole therapy.
AL‐12182, a Novel 11‐Oxa Prostaglandin Analogue with Topical Ocular Hypotensive Activity in the Monkey. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Charge-Carrier Trapping Dynamics in Bismuth-Doped Thin Films of MAPbBr3 Perovskite (2020)

Successful chemical doping of metal halide perovskites with small amounts of heterovalent metals has attracted recent research attention because of its potential to improve long-term material stability and tune absorption spectra. However, some additives have been observed to impact negatively on optoelectronic properties, highlighting the importance of understanding charge-carrier behavior in doped metal halide perovskites. Here, we present an investigation of charge-carrier trapping and conduction in films of MAPbBr<sub>3</sub> perovskite chemically doped with bismuth. We find that the addition of bismuth has no effect on either the band gap or exciton binding energy of the MAPbBr<sub>3</sub> host. However, we observe a substantial enhancement of electron-trapping defects upon bismuth doping, which results in an ultrafast charge-carrier decay component, enhanced infrared emission, and a notable decrease of charge-carrier mobility. We propose that such defects arise from the current approach to Bi-doping through addition of BiBr<sub>3</sub>, which may enhance the presence of bromide interstitials.
3D Die-to-wafer Cu/Sn Microconnects Formed Simultaneously with an Adhesive Dielectric Bond Using Thermal Compression Bonding (2008)

The simultaneous formation of Cu/Sn microconnects and an adhesive bond during wafer level thermal compression bonding was evaluated using a 3D enabled single metal level test die and wafer. The wafer level bond process relied on locally dispensed adhesive to fix the dice to the wafer prior to bonding and to become a permanent bond during the bonding process. The die-to-wafer microconnect resistance was measured for micropad pitches of 59, 64, and 69 μm. The robustness of the Cu/Sn and adhesive bond was demonstrated by thinning the bonded die to 50 BC;m. Package level reliability testing of parts that were wire bonded into a thermally enhanced plastic ball grid array (PBGA) package indicates good reliability behavior and the absence of any intrinsic reliability-related issues in the microconnects.
Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging (2014)

Patients with neocortical seizures and secondary generalisation had smaller volumes and microstructural anomalies in subcortical GM regions. Subcortical GM atrophy is relevant to the early onset and progression of epilepsy.
Conjugation of cRGD Peptide to Chlorophyll a Based Photosensitizer (HPPH) Alters Its Pharmacokinetics with Enhanced Tumor-Imaging and Photosensitizing (PDT) Efficacy (2011)

The α(v)β(3) integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Cyclic Arg-Gly-Asp (cRGD) peptide represents a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. For developing photosensitizers with enhanced PDT efficacy, we here report the synthesis of a series of bifunctional agents in which the 3-(1'-hexyloxyethyl)-3-devinylpyropheophorbide a (HPPH), a chlorophyll-based photosensitizer, was conjugated to cRGD and the related analogues. The cell uptake and in vitro PDT efficacy of the conjugates were studied in α(v)β(3) integrin overexpressing U87 and 4T1 cell lines whereas the in vivo PDT efficacy and fluorescence-imaging potential of the conjugates were compared with the corresponding nonconjugated photosensitizer HPPH in 4T1 tumors. Compared to HPPH, the HPPH-cRGD conjugate in which the arginine and aspartic acid moieties were available for binding to two subunits of α(v)β(3) integrin showed faster clearance, enhanced tumor imaging and enhanced PDT efficacy at 2-4 h postinjection. Molecular modeling studies also confirmed that the presence of the HPPH moiety in HPPH-cRGD conjugate does not interfere with specific recognition of cRGD by α(v)β(3) integrin. Compared to U87 and 4T1 cells the HPPH-cRGD showed significantly low photosensitizing efficacy in A431 (α(v)β(3) negative) tumor cells, suggesting possible target specificity of the conjugate.
Dual-frequency reflectarray design using sandwiched FSS (2010)

A concept using sandwiched frequency selective surface(FSS) as a frequency selective reflection plane is proposed for dual-frequency reflectarray system. The reflection phase range of a reflectarray relies on the thickness of the substrate. Usually, we need a tradeoff between the wide phase range and the smooth linear level, especially for dual-frequency system. By inserting an FSS between the reflectarray element layer and the metal ground plane, an additional reflecting plane for the upper frequency band is provided. For lower frequency band, the FSS layer is transparent and the reflecting plane is changed into the real metal ground plane. A 30° scattering angle reflectarray is designed to validate this concept.
Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives (2017)

N/A.
Benzocrown Ether Hydrazones as Extractants for Alkali Metal Ions (1993)

Abstract Four types of benzo-15-crown-5 and benzo-18-crown-6 derivatives bearing a substituted hydrazone moiety as a proton-dissociable chromogenic group were synthesized and the solvent extraction behaviors of these compounds for alkali metal ions were evaluated spectrophotometrically. Benzo-15-crown-5 and -18-crown-6 hydrazones with 2,4-dinitro-6-(trifluoromethyl)phenyl or 2,6-dinitro-4-(trifluoromethyl)phenyl groups extracted alkali metal ions predominantly as 2 : 1 and 1 : 1 (crown ether : metal ion) complexes, respectively, from an aqueous alkaline solution into 1,2-dichloroethane and these ligands exhibited high K+-selectivity. The composition of the extracted species and the K+-selectivity depended on the polarity of the extraction solvent used. In particular, 2 : 2 complexes of several alkali metal ions with benzo-15-crown-5 and -18-crown-6 hydrazones bearing a 2,4-dinitro-6-(trifluoromethyl)phenyl group were readily extracted from an aqueous solution into chloroform.
Nonlocal magnetoresistance measurements of the organic zero-gap conductor α−(BEDT−TTF)2I3 (2017)

We prepared nonlocal spin valves based on single crystals of an organic multilayered zero-gap conductor $\ensuremath{\alpha}\text{\ensuremath{-}}{(\mathrm{BEDT}\text{\ensuremath{-}}\mathrm{TTF})}_{2}{\mathrm{I}}_{3}$ and succeeded in evaluating the spin-diffusion length (1.1 \ensuremath{\mu}m) and relaxation time (3 ns) at 2.5 K under a static pressure of 1.6 GPa using a polyethylene naphthalate as a substrate. Although $\ensuremath{\alpha}\text{\ensuremath{-}}{(\mathrm{BEDT}\text{\ensuremath{-}}\mathrm{TTF})}_{2}{\mathrm{I}}_{3}$ includes heavy atoms, such as iodine, it exhibited a rather long spin-relaxation time comparable to that of graphene. The spin-orbit interaction (SOI) estimated on the basis of the experimental values of the spin-relaxation time and carrier lifetime (1.2 ps) was 90 mK. The long spin-relaxation time and small SOI evaluated for $\ensuremath{\alpha}\text{\ensuremath{-}}{(\mathrm{BEDT}\text{\ensuremath{-}}\mathrm{TTF})}_{2}{\mathrm{I}}_{3}$ are considered to originate from its layered structure in which spin scattering induced by surface defects is suppressed. In addition, the inversion asymmetry, which generates an extra term in the equation for the SOI, might be reduced in layered structures. These findings provide guiding principles for materials design in organic spintronics.
Demonstration of 40-Gb/s TDM-PON Over 42-km With 31 dB Optical Power Budget Using an APD-Based Receiver (2015)

We demonstrated a 40-Gb/s TDM-PON over a 42-km, 64-split fiber plant using optical duobinary modulation. In the ONU, a 25 Gb/s APD-based receiver was used for a cost-effective and low-power-consumption upgrade of TDM-PON. Experimental results show that our system supports 31 dB of power budget for a differential reach of 26 km at 1550 nm without DSP. Results of simulations to investigate optimization of the transmission performance are also presented.
Electronic structure manipulation via composition tuning for the development of highly conductive and acid-stable oxides (2022)

Our combined computations and experiments suggest the Mg-Ti-O chemical spaces for novel ternary oxide compounds that can offer high conductivity and corrosion stability to be used in fuel cell applications.
Clinical characteristics of people with cystic fibrosis and frequent fungal infection (2021)

Fungal infection in CF was associated with frequent P. aeruginosa and S. maltophilia co-infection even in those without ABPA. Individuals with frequent fungi and ABPA had worse outcomes, highlighting the potential contribution of fungi to CF pulmonary disease.
Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G in response to adrenalin (1988)

The glycogen-binding (G) subunit of protein phosphatase-1 is phosphorylated in vivo. In rabbits injected with propranolol the serine residue termed site-1 was phosphorylated in 56% of the molecules isolated, and phosphorylation increased to 82% after administration of adrenalin. It is concluded that the G-subunit is a physiological substrate for cyclic AMP-dependent protein kinase. The G-subunit remained largely bound to glycogen even after injection of adrenalin, whereas half of the protein phosphatase-1 activity associated with glycogen was released into the cytosol. The results indicate that adrenalin induces dissociation of the catalytic subunit from the G-subunit in vivo.
[Occult hereditary spherocytosis in aplastic crisis of unknown cause]. (1993)

We describe two cases of aplastic crisis of unknown origin, occurring within one week in a 49-year old man and his 20 year old son. They both had undiagnosed hereditary spherocytosis, and both of them had earlier had a B19-parvo infection without having symptoms of aplastic crisis at the same time. Chronic haemolytic anaemia should be considered in adult patients with acute severe anaemia caused by aplastic crisis.
Flexible BiVO4/WO3/ITO/Muscovite Heterostructure for Visible-Light Photoelectrochemical Photoelectrode (2021)

Flexible electronics has recently captured extensive attention due to its intriguing functionalities and great potential for influencing our daily life. In addition, with the increasing demand for green energy, photoelectrochemical (PEC) water splitting is a clean process that directly converts solar energy to chemical energy in the form of hydrogen. Thus the development of flexible green energy electronics represents a new domain in the research field of energy harvesting. In this work, we demonstrate the BiVO<sub>4</sub> (BVO)/WO<sub>3</sub>/ITO/muscovite heterostructure photoelectrode for water splitting with flexible characteristics. The performance of BVO was modified by specific crystal facets, and the BVO/WO<sub>3</sub> bilayer exhibited superior performance of 33% enhanced PEC activity at 1 V vs Ag/AgCl compared with pure BVO due to the proper staggered band alignment. Moreover, excellent mechanical stability was verified by a series of bending modes. This study demonstrates a pathway to a flexible photoelectrode for developing innovative devices for solar fuel generation.