gebhart/patrepeval huggingface dataset:
Heat-shock protein 60 is required for blastema formation and maintenance during regeneration (2005)

Zebrafish fin regeneration requires the formation and maintenance of blastema cells. Blastema cells are not derived from stem cells but behave as such, because they are slow-cycling and are thought to provide rapidly proliferating daughter cells that drive regenerative outgrowth. The molecular basis of blastema formation is not understood. Here, we show that heat-shock protein 60 (hsp60) is required for blastema formation and maintenance. We used a chemical mutagenesis screen to identify no blastema (nbl), a zebrafish mutant with an early fin regeneration defect. Fin regeneration failed in nbl due to defective blastema formation. nbl also failed to regenerate hearts. Positional cloning and mutational analyses revealed that nbl results from a V324E missense mutation in hsp60. This mutation reduced hsp60 function in binding and refolding denatured proteins. hsp60 expression is increased during formation of blastema cells, and dysfunction leads to mitochondrial defects and apoptosis in these cells. These data indicate that hsp60 is required for the formation and maintenance of regenerating tissue.
An LP Characterization of the Secret-message Capacity of Three Erasure Networks With Feedback (2016)

This paper presents exact capacity characterizations for the case, when a principal, Alice, wants to securely send a message to another principal, Bob, over three network configurations: the parallel edges network, the V-network, and the triangle network. We assume that: 1) a passive eavesdropper, Eve, overhears any one edge in the network; 2) each edge corresponds to an independent broadcast packet erasure channel with arbitrary erasure probabilities; and 3) all legitimate nodes can publicly but causally acknowledge whether they received each packet or not. We develop optimal achievability schemes that are expressed as linear programs (LPs) and share a two-phase structure, where at the first phase, we create secret keys, and at the second phase, we use them to encrypt the transmitted message. Our outer bounds are also expressed through LP formulations. We prove that our schemes are optimal by showing that the optimal solution of the outer bound LP and the optimal solution of the achievability scheme LP coincide.
Low charge noise quantum dots with industrial CMOS manufacturing (2022)

Silicon spin qubits are among the most promising candidates for large scale quantum computers, due to their excellent coherence and compatibility with CMOS technology for upscaling. Advanced industrial CMOS process flows allow wafer-scale uniformity and high device yield, but off the shelf transistor processes cannot be directly transferred to qubit structures due to the different designs and operation conditions. To therefore leverage the know-how of the micro-electronics industry, we customize a 300mm wafer fabrication line for silicon MOS qubit integration. With careful optimization and engineering of the MOS gate stack, we report stable and uniform quantum dot operation at the Si/SiOx interface at milli-Kelvin temperature. We extract the charge noise in different devices and under various operation conditions, demonstrating a record-low average noise level of 0.61 $μ$eV/${\sqrt{Hz}}$ at 1 Hz and even below 0.1 $μ$eV/${\sqrt{Hz}}$ for some devices and operating conditions. By statistical analysis of the charge noise with different operation and device parameters, we show that the noise source can indeed be well described by a two-level fluctuator model. This reproducible low noise level, in combination with uniform operation of our quantum dots, marks CMOS manufactured MOS spin qubits as a mature and highly scalable platform for high fidelity qubits.
A New Multi-Parameter Flow Cytometric Assay for Monitoring Lymphoma Growth and Spread in a Pre-Clinical Murine Model for Human Lymphoma. (2004)

Abstract Murine lymphoma models are commonly used to test the efficacy of idiotype-based vaccines for B-cell lymphoma prior to human trials. Mouse survival has been used as an indirect measure of the tumor response to the vaccine. In this study, we describe a multiparameter flow cytometric (MPFC) assay that enables direct assessment of the tumor at the inoculation site and detection of lymphoma metastases. In initial experiments, we show that 38C13 mouse lymphoma cells expressed an aberrant phenotype compared to normal splenocytes. The combination of CD45, CD19, B220 and an anti-idiotypic antibody (S1C5) along with a sequential gating technique defined the 38C13 cells with high sensitivity and specificity. The specificity of the MPFC assay for 38C13 lymphoma cells was greater than a gating strategy using light scatter and idiotype antibody binding. The MPFC assay was used to monitor 38C13 tumor kinetics in the C3H/HeN mouse and demonstrated tumor growth at the inoculation site and metastases to the lymph nodes and bone marrow. The presence of 38C13 metastases in lymphoid organs and bone marrow predicted by the MPFC assay were confirmed by histology and immunohistochemistry (IHC). The MPFC assay will enable investigators to monitor 38C13 lymphoma tumor response to individual vaccines or other lymphoma therapy prior to clinical trials. Furthermore, the MPFC concept could be readily applied to other models of human B cell lymphoma.
Polarity-invariant square law technology for transmitted reference UWB receivers digitizing with a monobit ADC (2012)

In this paper, two novel digital signal processing technologies, denoted as polarity-invariant square law (PISL) technology and forgetting factor based successive reference enhancement (SRE) technology, are proposed for transmitted reference (TR) based monobit receivers to compensate the quantization noise and enhance the quality of reference pulses. Since weighted TR (WTR) system can achieve a superior performance as well as a high data-rate under severe multipath environments, the PISL and SRE technologies are applied to the WTR receiver over intra-vehicle channels. The results show that compared to the SRE technology, the PISL technology enables a fixed summation time for all multipath channels, and significantly enhances the performance of the monobit ADC WTR receiver. Therefore, PISL technology is a promising technology to compensate the information loss caused by monobit quantization insuring high-performance, power efficient, and low complexity implementation for TR-based UWB receivers.
Lanthanide(III) Chelates for Selective Solution Phase Labeling of Biomolecules (2008)

Synthesis of photoluminescent lanthanide(III) chelates that allow selective solution phase labeling of bioactive molecules using phosphate elimination, native chemical ligation, and ‘click-chemisty’ is described. Keywords: Native chemical ligation, phosphate elimination, ‘click chemistry’, lanthanide(III) chelates, labeling
Polyfluorene Polyelectrolyte Nanoparticles: Synthesis of Innovative Stabilizers for Heterophase Polymerization (2014)

Polyfluorene-bearing bromohexyl side chains are quaternized by 1-vinylimidazole in order to attach dialkylimidazolium bromide ionic liquid (IL) species along the conjugated backbone. Subsequently, polyfluorene polyelectrolyte nanoparticles (NPs) of 40 nm in average size are created via radical cross-linking of the pendant vinylimidazolium groups. Anion exchange from Br(-) to BF(4)(-), PF(6)(-), and bis(trifluoromethylsulfonyl)imide anion (TFSI(-) renders NPs adjustable dispersability in various organic solvents. The hydrophobic-conjugated backbone and the hydrophilic dialkylimidazolium bromide IL moieties depict an amphiphilic profile, which allows the NPs to be deployed as conductive stabilizer in the emulsion polymerization of styrene. The resultant latexes are fluorescent, tunable in size and can be transferred to organic solvents without forfeiting their colloidal stability.
Whiter (or wither) UIMS? (1986)

The subject of User Interface Management Systems (UIMS) has been a topic of research and debate for the last several years. The goal of such systems has been to automate the production of user interface software. The problem of building quality user interfaces within available resources is a very important one as the demand for new interactive programs grows. Prototype UIMSs have been built and some software packages are presently being marketed as such. Many papers have been published on the topic.
How to Connect Device Nonlinear Specification and System Nonlinear Penalty (2022)

From system design point of view, it’s required to estimate nonlinear system performance from device nonlinear specification. We discuss various technologies about this topic and find the problem is only partially solved.
Evolution of INO Uncooled Infrared Cameras Towards Very High Resolution Imaging (2011)

Along the years INO has been involved in development of various uncooled infrared devices. Todays, the infrared imagers exhibit good resolutions and find their niche in numerous applications. Nevertheless, there is still a trend toward high resolution imaging for demanding applications. At the same time, low-resolution for mass market applications are sought for low-cost imaging solutions. These two opposite requirements reflect the evolution of infrared cameras from the origin, when only few pixel-count FPAs were available, to megapixel-count FPA of the recent years. This paper reviews the evolution of infrared camera technologies at INO from the uncooled bolometer detector capability up to the recent achievement of 1280×960 pixels infrared camera core using INO's patented microscan technology.
Altered tumor growth in vivo after immunization of mice with antitumor antibodies. (1984)

A comparison has been made between the growth patterns of two spontaneously appearing mammary adenocarcinomas in murine bone marrow radiation chimeras and in mice preimmunized with monoclonal antibodies (MAb) detecting embryo-associated antigenic determinants. A correlation was seen between the ability of the embryo-immunized chimeras to produce cytotoxic antibody to the tumors, as assessed by an antibody-dependent cellular cytotoxic assay, and the permissiveness of the mice for growth of a tumor transplant. In addition, mice deliberately preimmunized with cytotoxic MAb (antibody-dependent cellular cytotoxic assay) allowed more rapid growth specifically of that tumor earlier found to be most sensitive to the MAb used for immunization. By comparing the changing antigenic phenotype of tumor cells serially passaged through different immunized, nonimmunized mice, evidence was found suggesting that immunization could cause either antigen modulation of transferred tumor cells or a (transient) selective advantage to antigenically discrete subpopulations within the heterogeneous tumor population. Finally, we have studied the growth pattern of tumor cells transplanted into mice immunized with rabbit antibodies directed against the murine MAb. In this case, tumor growth was slowed preferentially for the tumor reactive with the specific MAb, and again, predictable changes in the antigenic spectrum of tumor cells harvested from these animals were observed. Our overall findings are interpreted in terms of the involvement of networks of antibodies reacting with embryo-associated antigens in the regulation of growth of the murine mammary adenocarcinomas studied.
Cytomegalovirus replicates efficiently in human kidney mesangial cells. (1988)

Human cytomegalovirus (HCMV) is a major renal pathogen in congenitally infected infants and renal allograft recipients. We postulated that a specific renal cell type was involved in HCMV infection and reactivation. Human fetal kidney cortex cell cultures were assayed for their ability to support HCMV infection. Infectious center assays indicated that the low level of viral replication observed by virus yield assay occurred from a fraction of the cells in the mixed cultures. Virus-specific immunofluorescence and in situ hybridization documented the presence of HCMV-specific protein and nucleic acid, respectively, in a morphologically distinct cell type. These cells were purified, were identified as kidney mesangial cells, and were observed to support efficient HCMV replication. Our research identifies mesangial cells as a renal cell type that supports HCMV replication and provides evidence to implicate these cells in the pathogenesis of HCMV-induced renal disease.
Preface (2004)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceIngo PinnauIngo PinnauMembrane Technology and Research, Inc. 1360 Willow Road, Suite 103 Menlo Park, CA 94025 650-328-2228 x 113 (telephone) 650-328-6580 (fax) [email protected] (email)More by Ingo Pinnau and Benny D. FreemanBenny D. FreemanCenter for Energy and Environmental Resources University of Texas at Austin 10100 Burnet Road, Building 133 Austin, TX 78758 512-232-2803 (telephone) 512-232-2807 (fax) [email protected] (email)More by Benny D. FreemanDOI: 10.1021/bk-2004-0876.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):April 20, 2004Publication History Published online23 July 2009Published inprint 20 April 2004Request reuse permissions Copyright © 2004 American Chemical Society. This publication is available under these Terms of Use. Advanced Materials for Membrane Separationspp xi-xiiiACS Symposium SeriesVol. 876ISBN13: 9780841238336eISBN: 9780841219816Chapter Views313Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (239 KB) Get e-Alerts
Sour Taste Responses in Mice Lacking PKD Channels (2011)

These findings suggest that PKD2L1 partly contributes to sour taste responses in mice and that receptors other than PKDs would be involved in sour detection.
Spin-wave nonreciprocity and formation of lateral standing spin waves in CoFeB/Ta/NiFe meander-shaped films (2022)

Studying the spin-wave (SW) propagation in 3D periodic structures opens new possibilities for joining functional units placed on the different layers of the magnonic circuitry. In the path toward 3D magnonics, the main challenge is the fabrication of large-scale 3D magnetic structures with nanometric precision control of geometry and material composition. In this work, we study the dependence on the Ta spacer thickness of the magnonic band structure, measured by Brillouin light scattering spectroscopy, of CoFeB/Ta/NiFe meander-shaped bilayers fabricated on pre-patterned Si substrate with thickness steps of 50 nm. Both propagating and stationary SW modes are observed. While the frequency of the dispersive mode slightly depends on the Ta spacer thickness, the frequency position of the three stationary modes in the lowest frequency range of the spectra significantly increases by increasing the Ta thickness. Micromagnetic calculations indicate that each of the three stationary modes is composed of a doublet of modes whose frequency separation, within each doublet, increases by increasing the mode frequency. The origin of this frequency separation is ascribed to the dynamic dipolar coupling between the magnetic layers that generate a significant frequency nonreciprocity of counterpropagating SWs. For these reasons, the investigated structures offer potential application as the nonreciprocal versatile interconnections performing the frequency selective regimes of signal propagation in magnonic circuits.
Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node (2017)

ABSTRACT A better understanding of antitumor immune responses is key to advancing the field of cancer immunotherapy. Endogenous immunity in cancer patients, such as circulating anticancer antibodies or tumor-reactive B cells, has been historically yet incompletely described. Here, we demonstrate that tumor-draining (sentinel) lymph node (SN) is a rich source for tumor-reactive B cells that give rise to systemic IgG anticancer antibodies circulating in the bloodstream of breast cancer patients. Using a synergistic combination of high-throughput B-cell sequencing and quantitative immunoproteomics, we describe the prospective identification of tumor-reactive SN B cells (based on clonal frequency) and also demonstrate an unequivocal link between affinity-matured expanded B-cell clones in the SN and antitumor IgG in the blood. This technology could facilitate the discovery of antitumor antibody therapeutics and conceivably identify novel tumor antigens. Lastly, these findings highlight the unique and specialized niche the SN can fill in the advancement of cancer immunotherapy. SIGNIFICANCE Using high-throughput molecular cloning and antibody proteomics to study coordinated antitumor immunity in breast cancer patients, we simultaneously demonstrate that the sentinel lymph node is a localized source of expanded antitumor B cells undergoing affinity maturation and that their secreted antibodies are abundant as systemic IgG circulating in blood.
Batteries: Recent Advances in Flexible Zinc‐Based Rechargeable Batteries (Adv. Energy Mater. 1/2019) (2019)

Flexible Zn-based batteries are emerging candidates for wearable electronics owing to the natural merits of zinc, such as environmental friendliness and low cost. In article number 1802605 by Cheng Zhong, Jun Lu, and co-workers, the challenges of developing flexible Li-ion batteries are presented. Thereafter, a brief overview of recent progress in the development of flexible Zn-based rechargeable batteries from the perspective of energy density, rechargeability, flexible electrolytes, and some other issues that remain to be addressed, are highlighted.
Ambience Separation from Mono Recordings Using Non-Negative Matrix Factorization (2007)

This article describes an approach to the problem of upmixing one-channel audio signals for multi-channel reproduction. The proposed method separates an ambient signal from an audio signal by computing the difference between the audio signal and a suitable approximation of the audio signal in the time-frequency domain. The approximation is derived by means of Non-negative Matrix Factorization minimizing the Kullback-Leibler divergence. A surround audio signal is generated by feeding the separated ambient signal into the rear channels. Results of extensive listening tests confirm the listeners' preference of the upmixed audio compared to unprocessed audio and competing upmix algorithms when played back on a 5.0 system.
Fast partitioning algorithm for HEVC Intra frame coding using machine learning (2014)

High Efficiency Video Coding (HEVC) is the new video coding standard recently approved by ISO and ITU. HEVC allows a bit rate reduction greater than a 50% with respect to its predecessor, the H.264/AVC, offering the same perceptual quality, by means of a set of new tools that have been introduced. Compared with the current state of the art in image coding, such as JPEG, JPEG2000 or the new JPEG XR, the new Intra Frame coding performs a high compression process in the "All-Intra" mode. All these improvements are at expense of a high computational cost, making it considerably difficult to implement in real time. Hence, this paper presents a mechanism that can be used by the RDO algorithm to select the optimal coding block size for Intra-Prediction, by using a data mining classifier, based on a previous training. Experimental results show that the proposed algorithm can achieve a 30% of Time Savings over a wide range of high resolution sequences (Class A, B and F), with a negligible loss of coding efficiency.
Long-term Reverse Total Shoulder Arthroplasty Outcomes: The Effect of the Inferior Shifting of Glenoid Component Fixation (2021)

In this study, at least 3.5 mm of inferior glenosphere overhang relative to the inferior rim of the glenoid was associated with the lower notching rate without negative effect on the clinical outcomes in 155° Grammont-style reverse shoulder replacement. Therefore, no increase in complications should be expected when using this surgical technique.
Advancing Model Pruning via Bi-level Optimization (2022)

The deployment constraints in practical applications necessitate the pruning of large-scale deep learning models, i.e., promoting their weight sparsity. As illustrated by the Lottery Ticket Hypothesis (LTH), pruning also has the potential of improving their generalization ability. At the core of LTH, iterative magnitude pruning (IMP) is the predominant pruning method to successfully find 'winning tickets'. Yet, the computation cost of IMP grows prohibitively as the targeted pruning ratio increases. To reduce the computation overhead, various efficient 'one-shot' pruning methods have been developed, but these schemes are usually unable to find winning tickets as good as IMP. This raises the question of how to close the gap between pruning accuracy and pruning efficiency? To tackle it, we pursue the algorithmic advancement of model pruning. Specifically, we formulate the pruning problem from a fresh and novel viewpoint, bi-level optimization (BLO). We show that the BLO interpretation provides a technically-grounded optimization base for an efficient implementation of the pruning-retraining learning paradigm used in IMP. We also show that the proposed bi-level optimization-oriented pruning method (termed BiP) is a special class of BLO problems with a bi-linear problem structure. By leveraging such bi-linearity, we theoretically show that BiP can be solved as easily as first-order optimization, thus inheriting the computation efficiency. Through extensive experiments on both structured and unstructured pruning with 5 model architectures and 4 data sets, we demonstrate that BiP can find better winning tickets than IMP in most cases, and is computationally as efficient as the one-shot pruning schemes, demonstrating 2-7 times speedup over IMP for the same level of model accuracy and sparsity.
Covalent immobilization of graphene oxide on biomedical grade CoCr alloy by an improved multilayer system assembly via Silane/GO bonding (2022)

Improvements in durable lubrication together with minimized wear are essential for obtaining long-term, functioning metallic joint prostheses. To achieve this objective, CoCr surface was functionalized with Graphene Oxide (GO) and characterized by FTIR and XPS. CoCr alloy was subjected to alkalinization in order to generate high hydroxyl content on the surface. FTIR and XPS revealed reactive OH groups, enabling intermediate coupling via (3-aminopropyl) triethoxysilane (APTES), which was cured at 45 °C and 75 °C for 24 h and 30 min, respectively. FTIR revealed cross-linked films (Si–O–Si), inferring condensation and self-assembly of silane layers, while XPS revealed the presence of NH2, enabling chemical binding of GO. Silane-coated CoCr disks were immersed in GO solution at 60 °C for 12h and 24h, respectively. FTIR displayed CC band confirming the assembly of GO on silane-coated CoCr surfaces. XPS revealed three possible surface mechanisms: (1) reaction between primary amines of APTES and epoxy groups of GO; (2) free –OH groups in APTES and carboxyl groups in GO; and (3) reaction between APTES primary amines and –OH from carboxyl groups of GO. Overall, the multilayer system CoCr–OH–Si45-GO24h showed covalent functionalization of metal substrate with GO to a large extension of surface area among all the multilayer systems studied.