gebhart/patrepeval huggingface dataset:
Outcomes of double-balloon enteroscopy-assisted direct percutaneous endoscopic jejunostomy tube placement (2016)

Compared with the published outcomes of DPEJ by conventional endoscopy, DBE-DPEJ tube placement was technically successful in a high proportion of patients (93 %) and with a relatively low rate of significant adverse events.
Antibacterial Resistance Leadership Group: Open for Business (2014)

Funded by the National Institute of Allergy and Infectious Diseases, the Antibacterial Resistance Leadership Group (ARLG) is tasked with developing a clinical research agenda and conducting clinical studies to address the growing public health threat of antibacterial resistance. The ARLG has identified 4 high-priority areas of research: infections caused by gram-negative bacteria, infections caused by gram-positive bacteria, antimicrobial stewardship and infection prevention, and diagnostics. The ARLG will be accepting proposals from the scientific community for clinical research that addresses 1 or more of these high-priority areas. These studies should have the potential to transform medical practice and be unlikely to occur without ARLG support. The purpose of this article is to make interested parties aware of clinical research opportunities made available by ARLG and to encourage submission of clinical research proposals that address the problem of antibacterial resistance.
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1 H -1,2,3-triazoles (2020)

Novel dicationic triazoles 1–60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the placement of cationic moieties as well as the nature of aromatic substituents influenced in vitro antiprotozoal activities of compounds 1–60 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian cells. Eight congeners displayed antitrypanosomal IC50 values below 10 nM. Thirty-nine dications were more potent against P. falciparum than pentamidine (IC50 = 58 nM) and eight analogues were more active than artemisinin (IC50 = 6 nM). Diimidazoline 60 exhibited antiplasmodial IC50 value of 0.6 nM. Seven congeners administered at 4 × 5 mg/kg by the intraperitoneal route cured at least three out of four animals in the acute mouse model of African trypanosomiasis. At 4 × 1 mg/kg, diamidine 46 displayed better antitrypanosomal efficacy than melarsoprol, curing all infected mice.
Generation of High-purity Ozone Beam and Its Application to the Formation of Ultra-thin Silicon Dioxide Film. (1997)

Fabrication of an ozone jet generator system and its application to the formation of ultra-thin silicon dioxide film was discussed. Superior features of using ozone and/or atomic oxygen in an oxidation process is highlighted through the comparison of reactivity among various oxidizing reagent, and also through the survey of their applications to SiO2 formation. Then the characteristics of the new ozone jet generator, which can supply high purity ozone flux and was specially designed to overcome the current problems in handling high purity ozone, was described in detail. Finally, the oxidation mechanism of Si with ozone, which was investigated by XPS and SHG methods, was discussed focusing on the role of atomic oxygen generated by the dissociation of ozone on silicon surface.
NOTCH1/FBXW7 Mutation Identifies a Large Subgroup with Favorable Outcome in Adult T-ALL: A GRAALL Study. (2008)

Abstract Background: In recent years, oncogenic understanding of T-ALL has led to the identification of multiple molecular markers. However, each molecular abnormality accounts for a small proportion of cases and risk stratification at diagnosis still relies on age, clinical presentation, and early response to therapy. NOTCH1 and/or FBXW7 mutations have been recently reported to be a recurrent abnormality in T-ALL, both leading to activation of the NOTCH pathway. Studies in pediatric series have suggested a favorable outcome for NOTCH1 mutated T-ALL, but this has not been evaluated in large series of adult cases. Furthermore, FBXW7 prognostic impact remains unknown in both populations. Methods: In order to evaluate the incidence of these mutations and their prognostic impact in adults, we performed a retrospective analysis of 141 patients (median age, 28 years) with T-ALL treated within the LALA-94 (N=87) or the more recent GRAALL-2003 (N=54) French trials. These patients were representative of the overall population since their outcome did not differ from the overall T-ALL cases treated in either LALA-94 (estimated 3-year OS, 41%) or GRAALL-2003 (estimated 3-year OS, 66%) trial. Furthermore, the patients from the LALA-94 and the GRAALL-2003 trials did not differ with respect to sex ratio, age, WBC, and initial complete remission rate (92% and 98%, respectively). Exons 26 (HD N-terminal), 27 (HD C-terminal), 28 (juxtamembrane domain) and 34 (transactivation domain TAD and the PEST domain) of NOTCH1 and exons 9, 10 and 12 of WD40 domain of FBXW7 were sequenced. Results: We identified 101 cases with NOTCH1 and/or FBXW7 mutations (72%) and 40 wild type (WT) samples (28%). NOTCH1 was mutated in 88 patients (59 HD only, 15 HD+PEST, 9 PEST only, 5 other). FBXW7 was mutated in 34 patients, alone in 13 cases or in association with NOTCH1 mutations in 21 cases. There was no significant correlation between NOTCH1 and/or FBXW7 mutations and immunophenotypic or oncogenetic features. There was a trend for a higher WBC and more frequent CNS involvement in patients demonstrating WT NOTCH1 and FBXW7. Similarly, high-risk MRC/ECOG criteria (age&amp;gt;35y and/or WBC&amp;gt;100G/L) were found in 56% of patients from the mutated subgroup versus 73% in the WT subgroup (P=0.06). The prognostic impact of NOTCH1 mutations alone did not reach statistical significance on multivariate analysis (P=0.09). On the other hand, multivariate analysis showed that the GRAALL-2003 trial and the presence of NOTCH1 and/or FBXW7 mutations were the only factors associated with a longer EFS (P=0.001 and 0.035, respectively). Median EFS was 36 months for patients with NOTCH1 and/or FBXW7 mutations versus 17 months for WT patients. Conclusions: These data demonstrate that NOTCH pathway activation by either NOTCH1 or FBXW7 mutation identifies a large group of T-ALL adult patients (72%) with a favorable outcome that could be used for treatment stratification.
Chemoselective Reductive Heterocyclization by Controlling the Binomial Architecture of Metal Particles and Acid–Base Properties of the Support (2017)

2,1-Benzisoxazoles have been selectively synthesized through reductive heterocyclization of 2-nitroacylarenes using Pt-supported nanoparticles. The reaction involves a cascade process in which the first step is the reduction of the nitro group into hydroxylamine followed by heterocyclization through the nucleophilic attack of the hydroxylamine group to the carbonyl of the acyl group and further dehydration. The reaction was performed on Pt/C, Pt/TiO2, and Pt/MgO using hydrogen as the reducing agent under mild reaction conditions. The results showed that Pt/MgO was the most active and selective catalyst. The study of the influence of the crystal size of the metal on the activity and selectivity, combined with the reaction mechanism examined by in situ Fourier transform infrared spectroscopy of the adsorbed reactant, showed that the maximum activity and selectivity to the target compound can be achieved by controlling the architecture of metal particles and acid–base properties of the support. The effect of temperature on selectivity, the stability of the Pt/MgO catalyst, and the scope of the reaction have been studied. Finally, reductive heterocyclization using different metals (Pd and Au) supported on MgO has also been performed.
Particle-Substrate Interaction Forces in a Non-Polar Liquid (2007)

status: Published
Antibacterial Activity of Honey against Strains of Staphylococcus Aureus from Infected Wounds (1999)

The antibacterial action of honey in infected wounds does not depend wholly on its high osmolarity. We tested the sensitivity of 58 strains of coagulase-positive Staphylococcus aureus, isolated from infected wounds, to a pasture honey and a manuka honey. There was little variation between the isolates in their sensitivity to honey: minimum inhibitory concentrations were all between 2 and 3% (v/v) for the manuka honey and between 3 and 4% for the pasture honey. Thus, these honeys would prevent growth of S. aureus if diluted by body fluids a further seven-fold to fourteen-fold beyond the point where their osmolarity ceased to be completely inhibitory. The antibacterial action of the pasture honey relied on release of hydrogen peroxide, which in vivo might be reduced by catalase activity in tissues or blood. The action of manuka honey stems partly from a phytochemical component, so this type of honey might be more effective in vivo. Comparative clinical trials with standardized honeys are needed.
ChemInform Abstract: Progress Toward Synthesis of Diazonamide A. Preparation of a 3‐(Oxazol‐5‐yl)‐4‐trifluoromethylsulfonyloxyindole and Its Use in Biaryl Coupling Reactions. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nonpolar Bistable Resistive Switching Behaviors of Bismuth Titanate Oxide Thin Film (2009)

Nonpolar bistable resistive switching behaviors of sol-gel derived bismuth titanate oxide (BTO) thin film are investigated in this study. The BTO thin film memory device without thermal treatment shows higher resistance ratio (∼ 10 4 ) than the other annealed devices. The resistive switching behavior of the Pt/BTO/LNO/Pt device is reproducible and can be traced over 100 times. Both low resistance state (ON-state) and high resistance state (OFF-state) are stable over 10 4 s under 0.3 V voltage stress at room temperature (RT) and 85°C. The retention behaviors of both memory states in the Pt/BTO/LNO/Pt device are very stable over 2 × 10 6 s at RT and 85°C, showing that the BTO thin film memory device is a good candidate for nonvolatile memory application
Catalytic Nanomotors: Self‐Propelled Sphere Dimers (2010)

Experimental and theoretical studies of the self-propelled motional dynamics of a new genre of catalytic sphere dimer, which comprises a non-catalytic silica sphere connected to a catalytic platinum sphere, are reported for the first time. Using aqueous hydrogen peroxide as the fuel to effect catalytic propulsion of the sphere dimers, both quasi-linear and quasi-circular trajectories are observed in the solution phase and analyzed for different dimensions of the platinum component. In addition, well-defined rotational motion of these sphere dimers is observed at the solution-substrate interface. The nature of the interaction between the sphere dimer and the substrate in the aqueous hydrogen peroxide phase is discussed. In computer simulations of the sphere dimer in solution and the solution-substrate interface, sphere-dimer dynamics are simulated using molecular-dynamics methods and solvent dynamics are modeled by mesoscopic multiparticle collision methods taking hydrodynamic interactions into account. The rotational and translational dynamics of the sphere dimer are found to be in good accord with the predictions of computer simulations.
Audio-visual musical instrument recognition (2011)

In 2008, a humanoid robot developed by Honda conducted a symphonic orchestra in front of a live audience. It per-fectly imitated the pre-recorded actions of the orchestra’s human conductor. Despite its realistic movements, it
Unsteady Simulations of a Low NOx LDI Combustor for Environmentally Responsible Aviation Engines (2015)

A key objective of NASA’s Environmentally Responsible Aviation (ERA) research program is to develop advanced technologies that enable 75% reduction of LTO NOx emissions of N+2 aviation gas turbine engines relative to the CAEP 6 standard. To meet this objective, a new advanced multi-point fuel injector was proposed and tested under the NASA ERA program. The new injector, called the three-zone injector, or 3ZI, uses fifteen spray cups arranged in three zones. Swirling air flows into each cup and fuel is introduced via pressure swirl atomizers within the cup. Multiple design parameters impact the performance of the injector, such as the location of the atomizer within the spray cup, the spray angle and cup-to-cup spacing. To fully understand the benefits and trade-offs of various injector design parameters and to optimize the performance of the injector, detailed CFD simulations are an essential tool. Furthermore, the CFD methodology must allow easy changes in design parameters and guarantee consistent and comparable accuracy from one design iteration to the next. This paper investigates the use of LES in reacting and non-reacting flows and compares against the NOx experimental data for the multi-point atomization strategy of the injector. The CFD simulations employ an automatically generated Cartesian cut-cell meshing approach with mesh refinement applied near complex geometry and spray regions. Adaptive Mesh Refinement (AMR) is used to refine mesh in regions of high gradients in velocity and temperature. The CFD simulations use boundary and operating conditions based on experimental data for air flow and spray atomization obtained from LDV and PDPA characterizations of the spray respectively. The results are extended to reacting flow using a detailed reaction mechanism and predictions of NOx emissions are compared to experimental data. Overall NOx predictions were consistently less than experimental values. However, the NOx prediction trends showed excellent agreement with experimental data across the wide range of equivalence ratios investigated.
Experimental results in bearings-only tracking using the sequential Monte-Carlo probability hypothesis density filter (2019)

We evaluate the use of a probability hypothesis density (PHD) filter in a bearings-only tracking application. The main feature of a PHD filter is that it propagates the first-order statistical moment of a multisource posterior distribution. Multisource estimation using a PHD filter has been shown to reliably track multiple simulated targets in the bearings-only case. In this paper we evaluate the utility of the sequential Monte-Carlo PHD filter for tracking surface ships using bearings-only data acquired from a Bluefin-21 unmanned underwater vehicle in Boston Harbor. The unmanned underwater vehicle was equipped with a rigidly mounted planar hydrophone array that measures the bearing angle to sources of acoustic noise, of which shipping traffic is the dominant source. We further evaluate several target maneuvering models, including clockwise and counter-clockwise coordinated turns. The combination of the coordinated turn models with a constant velocity model is used in a multiple model PHD filter. The results of the multiple model PHD filter are compared to the results of a PHD filter using only a constant velocity model.
Pourquoi la protéine phosphatase 2A est si utile aux virus et aux parasites.... (2000)

National audience
Abstract LB-265: Mutations in BRCA1 impair breast epithelial differentiation through the transcriptional repressor Slug (2010)

Abstract Human breast cancers can be broadly classified based on their molecular and gene expression profiles into luminal and basal-like tumors. These tumor subtypes express markers corresponding to the two major differentiation states of epithelial cells in the breast: luminal cells that line the breast ducts and the outer myoepithelial/basal cells that provide contractile functions. Women with inherited mutations in the BRCA1 gene have increased breast cancer risk and also exhibit a specific predisposition to the development of aggressive basal-like breast cancers. Accumulating evidence suggests that BRCA1 has a role in breast epithelial differentiation and we wanted to further understand how this could contribute to the formation of basal-like tumors. Microarray, flow cytometry and immunohistochemical analysis of breast epithelial cells from disease-free women harboring deleterious mutations in BRCA1 (BRCA1 mut/+) compared to those from BRCA1 +/+ reduction mammoplasties showed an increase in markers of basal differentiation and a decrease in markers of luminal differentiation. We also created breast cancers from single cell suspensions of BRCA1 mut/+ and BRCA1 +/+ epithelial cells that had been transformed with identical oncogenes and injected into humanized mammary fat pads. Tumors derived from BRCA1 mut/+ cells had increased basal differentiation relative to cells obtained from BRCA1 +/+ patients, indicating that the perturbed differentiation evident prior to neoplastic transformation was mirrored in the tumors. Pathway analysis of the microarray data comparing BRCA1 mut/+ and BRCA1 +/+ cells from disease-free tissue indicated that signaling components relating to the transcriptional repressor Slug were overexpressed in BRCA1 mut/+ tissues. We confirmed that Slug protein levels were elevated in BRCA1 mut/+ tissues and in human tumors from BRCA1 mutation carriers. RNAi-mediated downregulation of slug in primary breast epithelial cells and cell lines derived from BRCA1 mut/+ tissue as well as breast cancer cell lines known to harbor BRCA1 mutations, led to a decrease in markers of basal differentiation, indicating that elevated Slug protein levels seen in BRCA1-associated tissues and tumors are contributing to the basal phenotype. Furthermore, RNAi-mediated knockdown of BRCA1 led to an increase in Slug protein expression and breast cancer cell lines harboring BRCA1 mutations showed an increase in Slug protein stability, indicating that loss of BRCA1 protein by mutation contributes to elevated Slug protein levels. These results reveal an important mechanism by which BRCA1 can regulate breast epithelial differentiation and may explain how, in addition to affecting incidence rates, the genetic background of patients could impact tumor phenotype. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-265.
Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2 (2002)

Tumors have been thought to initiate as avascular aggregates of malignant cells that only later induce vascularization. Recently, this classic concept of tumor angiogenesis has been challenged by the suggestion that tumor cells grow by co-opting preexisting host vessels and thus initiate as well-vascularized tumors without triggering angiogenesis. To discriminate between these two mechanisms, we have used intravital epifluorescence microscopy and multi-photon laser scanning confocal microscopy to visualize C6 microglioma vascularization and tumor cell behavior. To address the mechanisms underlying tumor initiation, we assessed the expression of VEGF, VEGF receptor-2 (VEGFR-2), and angiopoietin-2 (Ang-2), as well as endothelial cell proliferation. We show that multicellular aggregates (<< 1 mm(3)) initiate vascular growth by angiogenic sprouting via the simultaneous expression of VEGFR-2 and Ang-2 by host and tumor endothelium. Host blood vessels are not co-opted by tumor cells but rather are used as trails for tumor cell invasion of the host tissue. Our data further suggest that the established microvasculature of growing tumors is characterized by a continuous vascular remodeling, putatively mediated by the expression of VEGF and Ang-2. The results of this study suggest a new concept of vascular tumor initiation that may have important implications for the clinical application of antiangiogenic strategies.
Nanometer size effect on magnetic order inLa0.4Ca0.6MnO3: Predominant influence of doped electron localization (2008)

The size effect in electron-doped ${\text{La}}_{0.4}{\text{Ca}}_{0.6}{\text{MnO}}_{3}$ manganite compound was explored by dc magnetic and $X$-band electron magnetic resonance measurements in temperature intervals $5--350\text{ }\text{K}$ and $5--600\text{ }\text{K}$. The analysis of experimental data verifies the stability of the antiferromagnetic ground state. It is suggested that the stability results from the localized nature of doped electrons in bulk and nanosamples, revealed by fitting the experimental electron paramagnetic resonance parameters to the theoretical models.
Gelsolin gene mutation—at codon 187—in familial amyloidosis, Finnish: DNA‐diagnostic assay (1992)

Familial amyloidosis, Finnish (FAF), is an autosomal dominant form of systemic amyloidosis with lattice corneal dystrophy and progressive cranial neuropathy as principal clinical manifestations. We have shown that the novel amyloid fibril protein found in these patients is an internal degradation fragment of gelsolin, an actin-binding protein, and that it contains an amino acid substitution, asparagine for aspartic acid at position 15, that is due to a guanine-to-adenine transversion corresponding to codon 187 of human plasma gelsolin cDNA. To test that this mutation cosegregates with the disease high-molecular-weight genomic DNA was isolated from autopsied tissues or lymphocytes of 23 patients, 6 healthy relatives and 20 unrelated healthy control persons. Specific fragments were amplified with the polymerase chain reaction for oligonucleotide hybridization analysis using the slot-blot technique. The guanine-to-adenine transversion was found in all FAF patients tested, but in none of the control subjects. Our results show that the mutation (G to A) cosegregates with the disease phenotype, and that the slot-blot analysis can be used as a diagnostic assay, including prenatal evaluation.
A dynamic model of failure scenarios of the dry cooler in a liquid cooled chiller-less data center (2015)

Data centers take up a significant portion of the national energy consumption in the U.S., accounting for approximately 2% of the total electricity used in 2010. Around the world that percentage is growing at a rapid rate. Within data centers, cooling systems constitute a large portion of the energy consumed, accounting for roughly 25-35% of total expenditures. Many new data center cooling technologies have been developed to improve cooling energy efficiency. A data center cooling facility proposed by IBM was constructed to reduce cooling energy use to less than 5% of the total Information Technology (IT) energy use, which was accomplished through a combination of warm water cooling servers and liquid-side economization. The heat load of IT equipment is rejected out to the ambient air without using a refrigeration/chiller plant or a Computer Room Air Handlers unit (CRAH), which consume a large amount of energy. This work develops simulation tools for the dry cooler, which is an air-to-liquid cross flow heat exchanger used in this cooling technology. Steady state test data is incorporated into the models, and is then used to validate them. The dynamic prediction accuracy of the simulation tool is also compared with real time measurement results of the dry cooler. Results of the simulation and testing are then used to obtain a more complete understanding of the dry cooler performance data and analyze the performance of the dry cooler in the cooling infrastructure. Failure analyses of the dry cooler are also performed in this work. One failure category of the dry cooler is parametrically modeled. The dynamic effects of failures of the dry cooler are reported and analyzed. The effects of the thermal mass of liquid and ambient air as well as the effects of natural convection and thermal, hydraulic characteristics of the external loop on the dynamic behavior of the dry cooler in this failure scenario are presented.