gebhart/patrepeval huggingface dataset:
Controlled Release Electron Donors: Hydrogen Release Compound (HRC)—An Overview of a Decade of Case Studies (2006)

ABSTRACT Hydrogen Release Compound (HRC) has been a commercially available product for engineered bioremediation of anaerobically biodegradable contaminants since 1999. HRC is a polylactate ester that, upon hydration or microbial cleavage of its ester bonds, slowly releases lactic acid. Lactic acid serves as an electron donor for microbial reductive biodegradation, while also providing hydrogen and carbon where required. HRC is a viscous amber-colored liquid that is typically injected into a contaminated aquifer using direct push technology or backfill injection into boreholes created by traditional drilling methods. Once in place, HRC creates a plume of lactic acid and its fermentation products (other organic acids and hydrogen) downgradient of the injection area and serves to accelerate anaerobic bioremediation processes. In this review of HRC field application results, the authors summarize application types, contaminants treated, site types, application locations, injection methods, site lithology and hydrology, and concentration ranges of geochemical species. The source of this information is a database of more than 850 HRC field applications, a series of 80 HRC publications that are publicly available, and 44 detailed site case histories that are available electronically.
Effects of the Strain Rate and Alloying on the Compression Characteristics of Closed Cell Aluminum Foams (2009)

Though closed cell Al foams have extremely low density and high energy absorption performance, they are expected to improve the compressive strength and to clear the dynamic compression characteristics for much more practical application.In this research, the effects of density, test piece size and alloying (Al-10.0 mass%Zn-0.3 mass%Mg) on the uniaxial static and dynamic compressive strength was examined. Dynamic compressive strength were examined by the Split Hopkinson Pressure Bar (SHPB) method and the drop weight impact test device.As a result, the dynamic plateau stress of pure Al foams was about 1.3 times larger than the static one, and there was a scale effect of test pieces.The dynamic plateau stress of Al alloy foams was about 1.1 times larger than the static one, and there was less scale effect of test pieces for plateau stress because the cell walls of Al alloy foams tend to collapse owing to brittleness by alloying.The effect of the inner gas enclosed in cells on the dynamic response of pure Al foams by SHPB is also discussed. When providing inner gas vent holes, dynamic plateau stress decreased close to the static one. With Al foams, the increasing in dynamic plateau stress may be caused by the inner gas pressure rising under dynamic compressive conditions as well as influence of the strength and ductility of the cell wall.
Developments for Physical Cleaning Sample with High Adhesion Force Particles and Direct Measurement of its Removal Force (2016)

We quantitatively evaluate the wet cleaning performance of particle cotamination. We made particle sample which endure the wet cleaning and measured particle adhesion force by self-sensitive cantilever. The advantage of this method is that performed in both air and water. As a result, there were no significant differences between the air and water condition and the influence of particle size were dominant. Using this sample, we demonstrated particle removal rate of droplets impacts and PVA brush.
Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs. (2000)

Caffeine inhibits the G2 checkpoint activated by DNA damage and enhances the toxicity of DNA-damaging agents towards p53-defective cancer cells. The relationship between structure and G2 checkpoint inhibition was determined for 56 caffeine analogs. Replacement of the methyl group at position 3 or 7 resulted in loss of activity, while replacement at position 1 by ethyl or propyl increased activity slightly. 8-Substituted caffeines retained activity, but were relatively insoluble. The structure-activity profile did not resemble those for other known pharmacological activities of caffeine. The active analogs also potentiated the killing of p53-defective cells by ionizing radiation, but none was as effective as caffeine.
Microfluidic chips for parallelized analytical crystallization (2006)

A crystallization method, a microplate and an instrument were developed, allowing for the first time the application of an objective and contact-free evaluation of clear drops as well as a robust evaluation of precipitates within crystallization experiments. Laser light scattering and polarization microscopy are used for an optical characterization of solute or precipitated proteins. Both approaches form the basis of an automated, rational and adaptive crystallization process. The implementation of well-documented and unbiased information derived from thermodynamic solution parameters such as the second virial coefficient (crystallization window) and the early and objective identification of microcrystalline precipitates will probably cause a paradigm shift in the way protein crystallization is approached. The new method is automated and performed using a new microplate and 200 nL droplets of the protein solution.
Aggregation and Amyloid Fibril Formation of the Prion Protein Is Accelerated in the Presence of Glycogen (2008)

Prion diseases like Creutzfeldt-Jakob disease in humans or scrapie in sheep and goats are infectious neurodegenerative diseases. Their infectious agent, called prion, is composed mainly of aggregated and misfolded prion protein and non-proteinaceous components. An example of such a common non-proteinaceous secondary component of natural prions is the polysaccharide scaffold. We studied the influence of such a polysaccharide on the conformational transition of PrP applying an in vitro conversion system. Here we report that glycogen supports and accelerates PrP amorphous aggregation similar to seeded aggregation and leads to co-aggregates. Furthermore, PrP fibril formation was highly accelerated in the presence of glycogen.
A microfluidic device for multiplex single-nucleotide polymorphism genotyping (2013)

Single-nucleotide polymorphisms (SNPs) are the most abundant type of genetic variations; they provide the genetic fingerprint of individuals and are essential for genetic biomarker discoveries. Accurate detection of SNPs is of great significance for disease prevention, diagnosis and prognosis, and for prediction of drug response and clinical outcomes in patients. Nevertheless, conventional SNP genotyping methods are still limited by insufficient accuracy or labor-, time-, and resource-intensive procedures. Microfluidics has been increasingly utilized to improve efficiency; however, the currently available microfluidic genotyping systems still have shortcomings in accuracy, sensitivity, throughput and multiplexing capability. To address these challenges, we developed a multi-step SNP genotyping microfluidic device, which performs single-base extension of SNP specific primers and solid-phase purification of the extension products on a temperature-controlled chip. The products are ready for immediate detection by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), providing identification of the alleles at the target loci. The integrated device enables efficient and automated operation, while maintaining the high accuracy and sensitivity provided by MS. The multiplex genotyping capability was validated by performing rapid, accurate and simultaneous detection of 4 loci on a synthetic template. The microfluidic device has the potential to perform automatic, accurate, quantitative and high-throughput assays covering a broad spectrum of applications in biological and clinical research, drug development and forensics.
Indoor Experimental Trial on Hybrid 16-Beam Spatial-Multiplexing for High SHF Wide-Band Massive MIMO in 5G (2018)

Recently, the fifth-generation mobile communications system (5G) in higher frequency bands has been extensively studied. Massive MIMO is one of the promising technologies to dramatically increase spectral efficiency. The authors have been engaged on R&D into wideband massive MIMO and beam control technologies for high SHF bands. Recently we have developed a massive MIMO system capable of supporting 16-beam transmission at a 28 GHz band and have conducted its experimental trial. In this paper, we present recent indoor experimental trial results using 16-beam spatial multiplexing at 28 GHz with 500 MHz bandwidth. For a single-user MIMO scenario, it has been verified that the downlink throughput of 25.5 Gbps is reached in the anechoic chamber.
Microwave Absorption and Molecular Structure in Liquids. VIII. Dielectric Relaxation in Some Long-Chain Esters1,2 (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrowave Absorption and Molecular Structure in Liquids. VIII. Dielectric Relaxation in Some Long-Chain Esters1,2P. L. McGeer, A. J. Curtis, G. B. Rathmann, and C. P. SmythCite this: J. Am. Chem. Soc. 1952, 74, 14, 3541–3545Publication Date (Print):July 1, 1952Publication History Published online1 May 2002Published inissue 1 July 1952https://pubs.acs.org/doi/10.1021/ja01134a025https://doi.org/10.1021/ja01134a025research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 291: RAS Fingerprinting: Patient-Specific Evaluation of the Renin-Angiotensin-System in Plasma by LC-MS/MS-Based Multiplex Quantification of Angiotensin Peptides (2012)

The Renin-Angiotensin-System (RAS) is critically involved in the regulation of important physiological functions including blood pressure and fluid balance. It is constituted by multiple enzymes giving rise to a meshwork of effector peptides, which mediate their functions through binding to specific receptor molecules. Therefore, the modification of angiotensin peptide levels represents a common strategy for the treatment of RAS-associated diseases and is frequently achieved by the pharmacologic regulation of enzymes taking part in angiotensin metabolism. We developed a highly sensitive method, which allows the simultaneous absolute quantification of up to 10 different angiotensin peptides in human plasma and whole blood (RAS-Fingerprinting). Either the measurement of in vivo RAS-Fingerprints (immediate sample stabilization) or heparin derived ex vivo RAS-Fingerprints in plasma or whole blood, provide unique insights into the biochemical constitution of the human RAS and therefore represent powerful tools for the patient specific evaluation of this physiologically important peptide hormone system. During the development and validation of a new LC-MS/MS based method for angiotensin quantification, comprehensive datasets for various applications of RAS-Fingerprinting have been generated. RAS-Fingerprints were measured in blood of healthy volunteers during the treatment with different RAS-blockers, which provided deep insights in the physiology and regulation of the human RAS and revealed surprising differences between individual patients. With the help of RAS-Fingerprinting, we were able to re-draw the picture of the human RAS at a previously unachieved level of detail and accuracy. Due to the availability of new selection criteria for pharmacologic screens, RAS-Fingerprinting could contribute to the development of innovative therapeutic approaches affecting the RAS. The extensive utilization of RAS-Fingerprinting in clinical studies will substantially enhance our understanding of the human RAS and could lead to the development of personalized treatment schemes in the management of RAS-associated diseases in the near future.
Validation of the MD Anderson Prognostic Risk Model for patients with myelodysplastic syndrome (2011)

Our data validated MDAS' prognostic value. MDAS is complementary to IPSS and refines prognostic precision.
CSMA/CA-based uplink MAC protocol design and analysis for hybrid VLC/Wifi networks (2017)

This paper proposes a multi-channel medium access control (MAC) protocol for hybrid VLC/Wifi networks. The proposed MAC protocol is based on an integration of two standards, IEEE 802.15.7 VLC and IEEE 802.11 Wifi CSMA/CA(s) (Carrier Sense Multiple Access/Collision Avoidance). We newly add on top of current MAC protocols a sub-layer that runs dynamic channel selection by taking intelligent control decisions, regarding channel aware and traffic aware. System performance metrics are analytically studied based on a combination of queuing and Markov chain theories. Numerical results quantitatively show how the proposed protocols significantly outperform the conventional ones.
A 5 GHz low power 0.18μm CMOS gilbert cell mixer (2005)

A 5 GHz low power double balanced Gilbert cell mixer on O.18 /spl mu/m CMOS process for a WLAN receiver front-end is investigated. The inductively degenerated Gilbert Cell mixer is simulated for its conversion gain, noise figure and linearity. The mixer has 6.6 dB conversion gain, 9 dB SSB NF, -5.4 dBm IIP3, consuming 5.4 mW from a 1.8 V power supply. The performance degradation at lower supply voltages and currents are investigated. The mixer provides similar performance from a 1.5 V supply consuming 4.5 mW.
Open-Air Plasma-Deposited Multilayer Thin Film Moisture Barriers for Perovskite Solar Cells (2020)

A scalable, open-air plasma process has been developed to deposit alternating layers of conformal organosilicate and dense SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin film barriers to prevent moisture ingress. The in-situ low temperature process is suitable for direct deposition on thermally sensitive perovskite devices and is compatible with flexible polymeric substrates. When deposited directly on perovskite solar cells, they retain over 80% of their initial performance for over 660 hours in a 50°C 50%RH accelerated aging environment. Using optical calcium testing, low water vapor transmission rates (WVTR) on the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> g/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /day at an accelerated aging condition of 38°C and 90% relative humidity (RH) are achieved. The ability of the multilayer barrier to enable device resistance to humid environments is crucial towards realizing longer operating lifetimes.
Genetic engineering of sulfur-degrading Sulfolobus. Final technical report, September 1, 1990--August 31, 1991 (1991)

The objectives of the proposed research is to first establish a plasmid-mediated genetic transformation system for the sulfur degrading Sulfolobus, and then to clone and overexpress the genes encoding the organic-sulfur-degrading enzymes from Sulfolobus- as well as from other microorganisms, to develop a Sulfolobus-based microbial process for the removal of both organic and inorganic sulfur from coal.
[Diagnostic strategies for ischemic enteropathies]. (2000)

Mesenteric ischemia is a life threatening event instead of colic ischemia which recovers in 90% of cases. Three points will be investigated: chronic mesenteric ischemia; acute mesenteric ischemia; colic ischemia.
Ultrafast Finite-Element Analysis of Brushless PM Machines Based on Space (2011)

A computationally efficient method is proposed for the steady-state performance simulation of brushless permanent-magnet (PM) motors. Only a minimum number of magnetostatic finite-element (FE) analysis (FEA) solutions are used in conjunction with space-time transformations, which are based on the periodicity specific to synchronous machines. For an example electronically controlled interior PM (IPM) motor with six teeth per pole and a distributed winding, a single nonlinear magnetostatic FE solution was employed to estimate the flux density time waveforms in the stator teeth and yoke. Other results include core losses, back electromotive force, and torque. The extension of the method to fractional-slot topologies with reduced number of teeth and concentrated (non-overlapping) coils is discussed with reference to a nine-slot six-pole IPM motor example. The computational time is reduced by one to two orders of magnitude as compared with more laborious time-stepping FEA. Successful validation was performed against experimental data and detailed FEA results.
Individualized System for Augmenting Ventilator Efficacy (iSAVE): A Rapidly deployable system to expand ventilator capacity (2020)

Abstract The COVID-19 pandemic is overwhelming healthcare systems worldwide. A significant portion of COVID-19 patients develop pneumonia and acute respiratory distress syndrome (ARDS), necessitating ventilator support. Some health systems do not have the capacity to accommodate this surge in ventilator demand, leading to shortages and inevitable mortality. Some clinicians have, of necessity, jerry-rigged ventilators to support multiple patients, but these devices lack protected air streams or individualized controls for each patient. Moreover, some have not been tested under conditions of ARDS. We have developed the Individualized System for Augmenting Ventilator Efficacy (iSAVE), a rapidly deployable platform to more safely use a single ventilator to simultaneously support multiple critically-ill patients. The iSAVE enables patient-specific volume and pressure control and incorporates safety features to mitigate cross-contamination between patients and flow changes due to patient interdependencies within the respiratory circuit. Here we demonstrate through simulated and in vivo pig evaluation the capacity of the iSAVE to support a range of respiratory clinical states. By leveraging off-the-shelf components that are readily available to intensive care unit (ICU) caregivers, the iSAVE could potentially be translated for human application to expand the ventilation capacity of hospitals using existing ventilators, minimizing the need to procure additional ventilators.
Advanced CD-SEM metrology for qualification of DSA patterns using coordinated line epitaxy (COOL) process (2016)

Directed self-assembly (DSA) applying chemical epitaxy is one of the promising lithographic solutions for next generation semiconductor device manufacturing. Especially, DSA lithography using coordinated line epitaxy (COOL) process is obviously one of candidates which could be the first generation of DSA applying PS-b-PMMA block copolymer (BCP) for sub-15nm dense line patterning . DSA can enhance the pitch resolutions, and can mitigate CD errors to the values much smaller than those of the originally exposed guiding patterns. On the other hand, local line placement error often results in a worse value, with distinctive trends depending on the process conditions. To address this issue, we introduce an enhanced measurement technology of DSA line patterns with distinguishing their locations in order to evaluate nature of edge placement and roughness corresponding to individual pattern locations by using images of CD-SEM. Additionally correlations among edge roughness of each line and each space are evaluated and discussed. This method can visualize features of complicated roughness easily to control COOL process. As a result, we found the followings. (1) Line placement error and line placement roughness of DSA were slightly different each other depending on their relative position to the chemical guide patterns. (2) In middle frequency area of PSD (Power Spectral Density) analysis graphs, it was observed that shapes were sensitively changed by process conditions of chemical stripe guide size and anneals temperature. (3) Correlation coefficient analysis using PSD was able to clarify characteristics of latent defect corresponding to physical and chemical property of BCP materials.
Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing (2017)

Cry6Aa1 is a <i>Bacillus thuringiensis</i> (<i>Bt</i>) toxin active against nematodes and corn rootworm insects. Its 3D molecular structure, which has been recently elucidated, is unique among those known for other <i>Bt</i> toxins. Typical three-domain <i>Bt</i> toxins permeabilize receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1-50 μg/ml range. Solubilization and proteolytic activation are necessary steps for PLB permeabilization. In contrast to other <i>Bt</i> toxins, Cry6Aa1 formed pores in receptor-free bilayers at doses as low as 200 pg/ml in a wide range of pH (5.5-9.5) and without the need of protease treatment. When Cry6Aa1 was preincubated with Western corn rootworm (WCRW) midgut juice or trypsin, 100 fg/ml of the toxin was sufficient to form pores in PLBs. The overall biophysical properties of the pores were similar for all three forms of the toxin (native, midgut juice- and trypsin-treated), with conductances ranging from 28 to 689 pS, except for their ionic selectivity, which was slightly cationic for the native and midgut juice-treated Cry6Aa1, whereas dual selectivity (to cations or anions) was observed for the pores formed by the trypsin-treated toxin. Enrichment of PLBs with WCRW midgut brush-border membrane material resulted in a 2000-fold reduction of the amount of native Cry6Aa1 required to form pores and affected the biophysical properties of both the native and trypsin-treated forms of the toxin. These results indicate that, although Cry6Aa1 forms pores, the molecular determinants of its mode of action are significantly different from those reported for other <i>Bt</i> toxins.
Supplementary Figure Legends from Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer (2023)

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Manufacturing porcine islets: culture at 22 °C has no advantage above culture at 37 °C: a gene expression evaluation (2013)

Culture of porcine islets at 37 °C provides benefits over culture at 22 °C with respect to OCR/DNA outcomes and reduced expression of genes encoding lymphocyte markers, lymphokines and chemokines, and markers for apoptosis and stress.