gebhart/patrepeval huggingface dataset:
The RAS ‐related GTP ase RHOB confers resistance to EGFR ‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT ‐dependent mechanism (2016)

Although lung cancer patients harboring EGFR mutations benefit from treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKI), most of them rapidly relapse. RHOB GTPase is a critical player in both lung carcinogenesis and the EGFR signaling pathway; therefore, we hypothesized that it could play a role in the response to EGFR-TKI In a series of samples from EGFR-mutated patients, we found that low RHOB expression correlated with a good response to EGFR-TKI treatment while a poor response correlated with high RHOB expression (15.3 versus 5.6 months of progression-free survival). Moreover, a better response to EGFR-TKI was associated with low RHOB levels in a panel of lung tumor cell lines and in a lung-specific tetracycline-inducible EGFR<sup>L</sup><sup>858R</sup> transgenic mouse model. High RHOB expression was also found to prevent erlotinib-induced AKT inhibition in vitro and in vivo Furthermore, a combination of the new-generation AKT inhibitor G594 with erlotinib induced tumor cell death in vitro and tumor regression in vivo in RHOB-positive cells. Our results support a role for RHOB/AKT signaling in the resistance to EGFR-TKI and propose RHOB as a potential predictor of patient response to EGFR-TKI treatment.
Planar reconfigurable slot antenna for communications (2001)

A new approach for implementing electronically tunable antennas is presented in this paper. The basic concept is to vary the effective electrical length of the antenna by controlling the bias conditions of solid state switches mounted on the slot. The implemented antennas is resonating at three different frequencies spanning the range of 550 to 700 MHz with no matching networks required.
Influence of molecular weight on the thermotropic mesophases of poly[6-[4-(4-methoxy-.beta.-methylstyryl)phenoxy]hexyl methacrylate] (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of molecular weight on the thermotropic mesophases of poly[6-[4-(4-methoxy-.beta.-methylstyryl)phenoxy]hexyl methacrylate]Virgil Percec, Dimitris Tomazos, and Coleen PughCite this: Macromolecules 1989, 22, 8, 3259–3267Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ma00198a012https://doi.org/10.1021/ma00198a012research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New Tyrosine Phosphorylation Site in PLCγ1: The Role of Tyrosine 775 in Immune Receptor Signaling (2005)

Phospholipase Cgamma (PLCgamma) is a ubiquitous gatekeeper of calcium mobilization and diacylglycerol-mediated events induced by the activation of Ag and growth factor receptors. The activity of PLCgamma is regulated through its controlled membrane translocation and tyrosine (Y) phosphorylation. Four activation-induced tyrosine phosphorylation sites have been previously described (Y472, Y771, Y783, and Y1254), but their specific roles in Ag receptor-induced PLCgamma1 activation are not fully elucidated. Unexpectedly, we found that the phosphorylation of a PLCgamma1 construct with all four sites mutated to phenylalanine was comparable with that observed with wild-type PLCgamma1, suggesting the existence of an unidentified site(s). Sequence alignment with known phosphorylation sites in PLCgamma2 indicated homology of PLCgamma1 tyrosine residue 775 (Y775) with PLCgamma2 Y753, a characterized phosphorylation site. Tyrosine 775 was characterized as a phosphorylation site using phospho-specific anti-Y775 antiserum, and by mutational analysis. Phosphorylation of Y775 did not depend on the other tyrosines, and point mutation of PLCgamma1 Y775, or the previously described Y783, substantially reduced AgR-induced calcium, NF-AT, and AP-1 activation. Mutation of Y472, Y771, and Y1254 had no effect on overall PLCgamma1 phosphorylation or activation. Although the concomitant mutation of Y775 and Y783 abolished downstream PLCgamma1 signaling, these two tyrosines were sufficient to reconstitute the wild-type response in the absence of functional Y472, Y771, and Y1254. These data establish Y775 as a critical phosphorylation site for PLCgamma1 activation and confirm the functional importance of Y783.
Supplementary Table S1 from Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04) (2023)

&lt;p&gt;Agilent and Resipher Assays in the TKF-1, RCB1292 and RCB1293 BTC Cell Lines in Figure 1B and 1C&lt;/p&gt;
New Selective Metal-Free Oxidations of Primary Alcohols by HNO3or HNO3and O2, Catalyzed by Br2 (2004)

Primary benzylic alcohols are selectively oxidized to the corresponding aromatic aldehydes by molecular oxygen at atmospheric pressure, under Br2-HNO3 catalysis in a biphasic medium (1,2-dichloroethane-water, 5:1) at 60 °C. Under paragonable experimental conditions the aliphatic alcohols are oxidized to esters.
Design of Under-Actuated Open-Chain Planar Robots for Repetitive Cyclic Motions (2006)

Under-actuated systems are unavoidable in certain applications. For example, a biped can not have an actuator between the foot and the ground. For industrial robots, underactuation is preferable due to cost considerations. A fully actuated system can execute any joint trajectory. However, if the system is under-actuated, not all joint trajectories are attainable. For such systems, it is difficult to characterize attainable joint trajectories analytically and numerical methods are generally used to characterize them. This paper investigates the property of differential flatness for under-actuated planar open chain robots and study its dependence on inertia distribution within the system. Once this property is established, trajectory between any two points in its differentially flat output space is feasible and can be shown to be consistent with the dynamics of the under-actuated system. It is shown that certain choices of inertia distributions make an under-actuated open-chain planar robot with revolute joints feedback linearizable, i.e., also differentially flat. Hence, both cyclic and point to point trajectories can be guaranteed with these under-actuated systems. The methodology proposed is demonstrated with an under-actuated three degree-of-freedom planar robot.
Electrical impedance tomography using induced currents: an experimental study (2005)

The theory behind induced current EIT is summarized. A prototype data acquisition system is described which is realized to verify the theoretical studies. Data collected from a two-dimensional (2D) object distribution is compared with the calculated data obtained by the finite element method. It is shown that the data acquisition system is capable of collecting real data which closely follows the theoretically expected perturbation in boundary potential differences. Images reconstructed by real data sets are indicatives of the sizes and locations of the inhomogeneities in the saline solution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
You are facing the Mona Lisa (2012)

This paper explores the viability of precise indoor localization using physical layer information in WiFi systems. We find evidence that channel responses from multiple OFDM subcarriers can be a promising location signature. While these signatures certainly vary over time and environmental mobility, we notice that their core structure preserves certain properties that are amenable to localization. We attempt to harness these opportunities through a functional system called PinLoc, implemented on off-the-shelf Intel 5300 cards. We evaluate the system in a busy engineering building, a crowded student center, a cafeteria, and at the Duke University museum, and demonstrate localization accuracies in the granularity of 1m x 1m boxes, called "spots". Results from 100 spots show that PinLoc is able to localize users to the correct spot with 89% mean accuracy, while incurring less than 6% false positives. We believe this is an important step forward, compared to the best indoor localization schemes of today, such as Horus.
Acoustic and system parameters affecting destruction of ultrasound contrast agents (1998)

In order to effectively use ultrasound contrast agents (UCAs), it is necessary to tune the ultrasound scanner parameters to a particular agent or change the characteristics of the UCA to target-specific applications. Both efforts are being sought by ultrasound manufacturers and pharmaceutical companies. The destruction of UCAs is usually undesirable, although it can sometimes be used advantageously such as in harmonic imaging mode. In the present work, changes in acoustic and system parameters such as frequency, transmitted acoustic pressure, pulse repetition frequency, flow rate, diluting media, concentration, and type of contrast agents were measured at both first and second harmonic. A prototype Doppler system previously described [Chang et al., Ultrasound Med. Biol. 22, 1205–1214 (1996)] has been adapted to carry out these measurements. Results with Albunex show that bubble destruction increases with an increase in flow rate, acoustic pressure, PRF, and decreases with an increase in the concentration of the contrast agent and oxygen content in the diluting medium. In conclusion, the rupture of UCAs are influenced by several imaging parameters. The threshold values when destruction of the agents occurs should be known in order to optimize the use of UCAs in clinical settings. [Work supported by DARPA-TRP.]
The reaction of alkynes with (ethoxyalkylidene)tetracarbonyliron(0) complexes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe reaction of alkynes with (ethoxyalkylidene)tetracarbonyliron(0) complexesM. F. Semmelhack, Rui Tamura, Wayne Schnatter, and James SpringerCite this: J. Am. Chem. Soc. 1984, 106, 18, 5363–5364Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ja00330a061https://doi.org/10.1021/ja00330a061research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Single Trial Decoding of Movement Intentions Using Functional Ultrasound Neuroimaging (2020)

Abstract Brain-machine interfaces (BMI) are powerful devices for restoring function to people living with paralysis. Leveraging significant advances in neurorecording technology, computational power, and understanding of the underlying neural signals, BMI have enabled severely paralyzed patients to control external devices, such as computers and robotic limbs. However, high-performance BMI currently require highly invasive recording techniques, and are thus only available to niche populations. Here, we show that a minimally invasive neuroimaging approach based on functional ultrasound (fUS) imaging can be used to detect and decode movement intention signals usable for BMI. We trained non-human primates to perform memory-guided movements while using epidural fUS imaging to record changes in cerebral blood volume from the posterior parietal cortex – a brain area important for spatial perception, multisensory integration, and movement planning. Using hemodynamic signals acquired during movement planning, we classified left-cued vs. right-cued movements, establishing the feasibility of ultrasonic BMI. These results demonstrate the ability of fUS-based neural interfaces to take advantage of the excellent spatiotemporal resolution, sensitivity, and field of view of ultrasound without breaching the dura or physically penetrating brain tissue.
Supplementary Figure S1 from Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment (2023)

&lt;p&gt;Supplementary Figure S1 illustrates ARX788 metabolism study in HCC1954 (HER2 expressing) cells. The metabolite pAF-AS269 was more abundantly detected in the cell sample than in the culture medium (A). Briefly, after ARX788 incubation for various time points, supernatant was collected from the wells and centrifuged to pellet floating cells. The resulting supernatant was processed as the medium sample, while the cell pellet was combined with the remaining adherent cells and processed as the cell sample, for LC-MS analysis. Additionally, the cell sample was counted in a hemacytometer to determine cell number and protein content was measured by BCA analysis. When compared to untreated cells, ARX788 inhibited HCC1954 cellular proliferation with fewer cells (B) and lower protein content (C) observed after 24-hours. Cell number (D) and protein content (E) remained unchanged in ARX788-treated and untreated MDA-MB-468 cells, a non-HER2 expressing cell line.&lt;/p&gt;
Signal and noise extraction from analog memory elements for neuromorphic computing (2018)

Dense crossbar arrays of non-volatile memory (NVM) can potentially enable massively parallel and highly energy-efficient neuromorphic computing systems. The key requirements for the NVM elements are continuous (analog-like) conductance tuning capability and switching symmetry with acceptable noise levels. However, most NVM devices show non-linear and asymmetric switching behaviors. Such non-linear behaviors render separation of signal and noise extremely difficult with conventional characterization techniques. In this study, we establish a practical methodology based on Gaussian process regression to address this issue. The methodology is agnostic to switching mechanisms and applicable to various NVM devices. We show tradeoff between switching symmetry and signal-to-noise ratio for HfO<sub>2</sub>-based resistive random access memory. Then, we characterize 1000 phase-change memory devices based on Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> and separate total variability into device-to-device variability and inherent randomness from individual devices. These results highlight the usefulness of our methodology to realize ideal NVM devices for neuromorphic computing.
The effect of nano‐sized silicate layers from montmorillonite on glass transition, dynamic mechanical, and thermal degradation properties of segmented polyurethane (2002)

Abstract The glass transition temperature of the hard‐segment phase and the storage modulus of segmented polyurethane increased substantially in the presence of a small amount of tethered nano‐sized layered silicates from montmorillonite compared with their pristine state (by 44°C and by 2.8‐fold, respectively). Furthermore, the heat resistance and degradation kinetics of these montmorillonite/polyurethane nanocomposites were enhanced, as shown by thermogravimetric analysis. In particular, a 40°C increase in the degradation temperature and a 14% increase in the degradation activation energy occurred in polyurethane containing 1 wt % trihydroxyl swelling agent‐modified montmorillonite compared to that of the pristine polyurethane. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 1741–1748, 2002
In search of the lost tradition: towards a history of church painting of the 1830s — 1st half of the 1840s (2022)

Fast moving Europeanisation of Russia, started by Peter the Great and continued by his successors, showed itself, among other things, in founding the Imperial Academy of Fine Arts and in the birth of Russian academic school, whose brilliant achievements were not in the least the legacy of Russian art tradition, especially that of icon-painting, for the latter was only allowed to exist as the arts of the commoners. This state of things was regarded as something to overcome during the reign of Nicholas I, when gradual re-establishment of the ties with tradition begins, seen in particular in the "Byzantine style" in Church architecture, invented by K.A. Ton in late 1820s - early 1830s at the behest of the emperor. Conservative ideology, expressed as it was in the so called theory of the official nationhood (narodnost'), starting from the times when S.S. Uvarov, the author of this theory, was appointed Minister of Public Instruction, was not reflected, however, in the academic Church painting and in the paintings which belonged to historic genre as a whole. This article is focused on the views on the academic Church paintings and traditional icon-paintings that were typical of the educated class of the 1830s and early 1840s. It is shown that the contemporaries of Russian "historical" painters, including those in the Church, saw their calling in commitment to the people (narodnost'), for "there is a need to assume... one's own character, which, while retaining its originality, would tend toward the general harmony with the European Art"; at least a part of the society has come to the opinion that at the time of the decline of famous schools of the West, it is in Russia that paintings show "life and development". (I.V. Kookolnik). In Church paintings of the 1830s the "Russian" style, oriented at the monuments of the past, originated not in the academic school itself, but in the adminicular activity, that is, as a by-product of the artistic and archaeological studies of F.G. Solntsev. A.N. Olenin, the President of the Academy of Arts, on whose intiative these studies were performed, envisaged their outcome as "the complete painting course of archaeology and ethnography for the artists". This course was born in the 1830s during two works of the artist: the making of Church calendar and the painting of Terem Palace and the churches in the Moscow Kremlin.
Fowler–Nordheim Tunneling in Electromigrated Break Junctions with Porphyrin Molecules (2007)

We measured the current–voltage (I–V) curves of 158 electromigrated break junctions with a Co(II) complex of tetraphenylporphyrin derivative (CoBSTBPP) at a temperature of 11 K within the applied bias ≤1.0 V. Symmetry I–V curves were observed in 18.4% of the measured junctions, and we found that Fowler–Nordheim tunneling is dominant in most of these junctions. The tunneling barrier height estimated from these I–V curves was smaller than 0.5 eV, which could be explained by considering the energy levels in CoBSTBPP and the Fermi level of an electrode. We conclude that CoBSTBPP forms the small tunneling barrier height in the molecular junctions.
Supplementary figures and figure legends from Targeting a Single Alternative Polyadenylation Site Coordinately Blocks Expression of Androgen Receptor mRNA Splice Variants in Prostate Cancer (2023)

&lt;p&gt;This file contains supplementary figures S1-S10 and corresponding figure legends. Figure S1: TALEN activity and genetic correction of 22Rv1 sub-lines. Figure S2: 5' and 3' breakpoint sequence junctions of 22Rv1 undup1-3 sub-lines. Figure S3: AR subcellular localization in 22Rv1-undup3 cell line. Figure S4: AR target gene expression panel in 22Rv1 and gene corrected sublines. Figure S5: Knockdown of splicing factors U2AF2, SRSF1, and PTBP1. Figure S6: Blockade of the AR CE3 PAS blocks AR-V expression in LNCaP and VCaP cells. Figure S7: Knockdown of CE3 in 22Rv1 and VCaP cells. Figure S8: Mutual exclusivity matrix depicting co-occurrence of alterations in the core CPSF complex. Figure S9: Confirmation of CPSF complex gene knockdown. Figure S10: Knockdown of CPSF1 in LNCaP95 cells.&lt;/p&gt;
Panel 4: Report of the Microbiology Panel (2017)

Objective To perform a comprehensive review of the literature from July 2011 until June 2015 on the virology and bacteriology of otitis media in children. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels comprising experts in the virology and bacteriology of otitis media were created. Each panel reviewed the relevant literature in the fields of virology and bacteriology and generated draft reviews. These initial reviews were distributed to all panel members prior to meeting together at the Post-symposium Research Conference of the 18th International Symposium on Recent Advances in Otitis Media, National Harbor, Maryland, in June 2015. A final draft was created, circulated, and approved by all panel members. Conclusions Excellent progress has been made in the past 4 years in advancing our understanding of the microbiology of otitis media. Numerous advances were made in basic laboratory studies, in animal models of otitis media, in better understanding the epidemiology of disease, and in clinical practice. Implications for Practice (1) Many viruses cause acute otitis media without bacterial coinfection, and such cases do not require antibiotic treatment. (2) When respiratory syncytial virus, metapneumovirus, and influenza virus peak in the community, practitioners can expect to see an increase in clinical otitis media cases. (3) Biomarkers that predict which children with upper respiratory tract infections will develop otitis media may be available in the future. (4) Compounds that target newly identified bacterial virulence determinants may be available as future treatment options for children with otitis media.
Electrical tuning of metastable dielectric constant of ferroelectric single crystals for low-power electronics (2011)

Electrical control of the dielectric constant in (011) [Pb(Mg1/3Nb2/3)O3](1−x)-[PbTiO3]x (PMN-PT, x ≈ 0.32) single crystal ferroelectric material is reported. It is demonstrated that the metastable dielectric constant value of (011) PMN-PT can be manipulated from approximately 3000 to 1000 by applying electric pulses of different amplitudes. These metastable properties are due to non-180° polarization reorientation within the ferroelectric crystals. Taking advantage of the tunable and metastable dielectric constant, a reconfigurable RC oscillator as well as a ferroelectric memory device is demonstrated. The reconfigurability of this ferroelectric capacitor and potential applications for low-power electronics are described.