gebhart/patrepeval huggingface dataset:
Lightweight uncooled TWS equipped with catadioptric optics and microscan mechanism (2006)

A rugged lightweight thermal weapon sight (TWS) prototype was developed at INO in collaboration with DRDC-Valcartier. This TWS model is based on uncooled bolometer technology, ultralight catadioptric optics, ruggedized mechanics and electronics, and extensive onboard processing capabilities. The TWS prototype operates in a single 8-12 &#956;m infrared (IR) band. It is equipped with a unique lightweight athermalized catadioptric objective and a bolometric IR imager with an INO focal plane array (FPA). Microscan technology allows the use of a 160 x 120 pixel FPA with a pitch of 50 &#956;m to achieve a 320 × 240 pixel resolution image thereby avoiding the size (larger optics) and cost (expensive IR optical components) penalties associated with the use of larger format arrays. The TWS is equipped with a miniature shutter for automatic offset calibration. Based on the operation of the FPA at 100 frames per second (fps), real-time imaging with 320 x 240 pixel resolution at 25 fps is available. This TWS is also equipped with a high resolution (857 x 600 pixels) OLED color microdisplay and an integrated wireless digital RF link. The sight has an adjustable and selectable electronic reticule or crosshair (five possible reticules) and a manual focus from 5 m to infinity standoff distance. Processing capabilities are added to introduce specific functionalities such as image inversion (black hot and white hot), image enhancement, and pixel smoothing. This TWS prototype is very lightweight (~ 1100 grams) and compact (volume of 93 cubic inches). It offers human size target detection at 800 m and recognition at 200 m (Johnson criteria). With 6 Li AA batteries, it operates continuously for 5 hours and 20 minutes at room temperature. It can operate over the temperature range of -30<sup>o</sup>C to +40<sup>o</sup>C and its housing is completely sealed. The TWS is adapted to weaver or Picatinny rail mounting. The overall design of the TWS prototype is based on feedbacks of users to achieve improved user-friendly (e.g. no pull-down menus and no electronic focusing) and ergonomic (e.g. locations of buttons) features.
Future Prospects of RF Hadron Beam Profile Monitors for Intense Neutrino Beam (2017)

A novel beam monitor based on a gas-filled RF resonator is proposed to measure the precise profile of secondary particles downstream of a target in the LBNF beam line at high intensity. The RF monitor is so simple that it promises to be radiation robust in extremely high-radiation environment. When a charged beam passes through a gas-filled microwave RF cavity, it produces electron-ion pairs in the RF cavity. The induced plasma changes the gas permittivity in proportion to the beam intensity. The permittivity shift can be measured by the modulated RF frequency and quality factor. The beam profile can thus be reconstructed from the signals from individual RF cavity pixels built into the beam profile monitor. A demonstration test is underway, and the current results has shown technical feasibility. The next phase consists of two stages, (1) to build and test a new multi-cell 2.45 GHz RF cavity that can be used for the NuMI beamline, and (2) to build and test a new multi-cell 9.3 GHz RF cavity that can be put in service in a future beamline at the LBNF for spatial resolution. These two resonant frequencies are chosen since they are the standard frequencies for magnetron RF source.
Mercury(II) cyanide complexes with alkyldiamines: solid-state/solution NMR, computational, and antimicrobial studies (2012)

Mercury cyanide complexes of alkyldiamines (1–6), [Hg(L)(CN)2] (where L = en (1,2-diaminoethane), pn (1,3-diaminopropane), N-Me-en, N, N′-Me2-en, N, N′-Et2-en, and N, N′-ipr2-en), have been synthesized and characterized by elemental analysis, IR, 13C, and 15N solution NMR in DMSO-d6, as well as 13C, 15N, and 199Hg solid-state NMR spectroscopy. Complexes 1 and 2 have been studied computationally, built and optimized by GAUSSIAN03 using DFT at B3LYP level with LanL2DZ basis set. Binding modes of en and bn (where bn = 1,4-diaminobutane) toward Hg(CN)2 are completely different. Complexes with en and pn show chelating binding to Hg(II), while bn behaves as a bridging ligand to form a polymeric structure, [Hg(CN)2-bn]∞ [B.A. Al-Maythalony, M. Fettouhi, M.I.M. Wazeer, A.A. Isab. Inorg. Chem. Commun., 12, 540 (2009).]. The solution 13C NMR of the complexes demonstrates a slight shift of the −C≡N (0.9 to 2 ppm) and −C–NH2 (0.25 to 6 ppm) carbon resonances, while the other resonances are relatively unaffected. 15N labeling studies have shown involvement of alkyldiamine ligands in coordination to the metal. The principal components of the 13C, 15N, and 199Hg shielding tensors have been determined from solid-state NMR data. Antimicrobial activity studies show that the complexes exhibit higher antibacterial activities toward various microorganisms than Hg(CN)2.
Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents (2017)

Skin health is associated with the day-to-day activity of fibroblasts. The primary function of fibroblasts is to synthesize structural proteins, such as collagen, extracellular matrix proteins, and other proteins that support the structural integrity of the skin and are associated with younger, firmer, and more elastic skin that is better able to resist and recover from injury. At sub-nanomolar concentrations (0.03-0.3 nM), bryostatin-1 and its synthetic analog, picolog (0.1-10 nM) sustained the survival and activation of human dermal fibroblasts cultured under the stressful condition of prolonged serum deprivation. Bryostatin-1 treatment stabilized human skin equivalents (HSEs), a bioengineered combination of primary human skin cells (keratinocytes and dermal fibroblasts) on an extracellular matrix composed of mainly collagen. Fibroblasts activated by bryostatin-1 protected the structural integrity of HSEs. Bryostatin-1 and picolog prolonged activation of Erk in fibroblasts to promote cell survival. Chronic stress promotes the progression of apoptosis. Dermal fibroblasts constitutively express all components of Fas associated apoptosis, including caspase-8, an initiator enzyme of apoptosis. Prolong bryostatin-1 treatment reduced apoptosis by decreasing caspase-8 and protected dermal fibroblasts. Our data suggest that bryostatin-1 and picolog could be useful in anti-aging skincare, and could have applications in tissue engineering and regenerative medicine.
Controlled-Release Oral Morphine (MS Contin Tablets, MSC) in Post-Operative Pain (1991)

Brown, J. D.1; Van Wagoner, J. D.2; O'Callaghan, R.1; Kaiko, R. F.3; Grandy, R. P.3; Fitzmartin, R.3Author Information
Synthetic aperture focusing for short-lag spatial coherence imaging (2013)

It has been demonstrated that short-lag spatial coherence (SLSC) ultrasound imaging can provide improved speckle SNR and lesion CNR compared with conventional Bmode images, especially in the presence of noise and clutter. Application of the van Cittert-Zernike theorem predicts that coherence among the ultrasound echoes received across an array is reduced significantly away from the transmit focal depth, leading to a limited axial depth of field in SLSC images. Transmit focus throughout the field of view can be achieved using synthetic aperture methods to combine multiple transmit events into a single final image. A synthetic aperture can be formed with either focused or diverging transmit beams. We explore the application of these methods to form synthetically focused channel data to create SLSC images with an extended axial depth of field. An analytical expression of SLSC image brightness through depth is derived for the dynamic receive focus case. Experimental results in a phantom and in vivo are presented and compared with dynamic receive focused SLSC images, demonstrating improved SNR and CNR away from the transmit focus and an axial depth of field four to five times longer.
3D TEDOR NMR Experiments for the Simultaneous Measurement of Multiple Carbon−Nitrogen Distances in Uniformly13C,15N-Labeled Solids (2002)

We describe three-dimensional magic-angle-spinning NMR experiments for the simultaneous measurement of multiple carbon-nitrogen distances in uniformly (13)C,(15)N-labeled solids. The approaches employ transferred echo double resonance (TEDOR) for (13)C-(15)N coherence transfer and (15)N and (13)C frequency labeling for site-specific resolution, and build on several previous 3D TEDOR techniques. The novel feature of the 3D TEDOR pulse sequences presented here is that they are specifically designed to circumvent the detrimental effects of homonuclear (13)C-(13)C J-couplings on the measurement of weak (13)C-(15)N dipolar couplings. In particular, homonuclear J-couplings lead to two undesirable effects: (i) they generate anti-phase and multiple-quantum (MQ) spin coherences, which lead to spurious cross-peaks and phase-twisted lines in the 2D (15)N-(13)C correlation spectra, and thus degrade the spectral resolution and prohibit the extraction of reliable cross-peak intensities, and (ii) they significantly reduce cross-peak intensities for strongly J-coupled (13)C sites (e.g., CO and C(alpha)). The first experiment employs z-filter periods to suppress the anti-phase and MQ coherences and generates 2D spectra with purely absorptive peaks for all TEDOR mixing times. The second approach uses band-selective (13)C pulses to refocus J-couplings between (13)C spins within the selective pulse bandwidth and (13)C spins outside the bandwidth. The internuclear distances are extracted by using a simple analytical model, which accounts explicitly for multiple spin-spin couplings contributing to cross-peak buildup. The experiments are demonstrated in two U-(13)C,(15)N-labeled peptides, N-acetyl-L-Val-L-Leu (N-ac-VL) and N-formyl-L-Met-L-Leu-L-Phe (N-f-MLF), where 20 and 26 (13)C-(15)N distances up to approximately 5-6 A were measured, respectively. Of the measured distances, 10 in N-ac-VL and 13 in N-f-MLF are greater than 3 A and provide valuable structural constraints.
Screen-Printable, Self-Biased SrM/PDMS Composites for Integrated Magnetic Microwave Devices (2021)

This work introduces a material and method for high-volume, low-temperature, screen printing of self-biased magnetic films made from a composite of M-type strontium ferrite SrFe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">19</sub> (SrM) particles and polydimethylsiloxane (PDMS). The magnetic particles are aligned under a dc magnetic field, while the PDMS is cured at 75 °C, making this fabrication process compatible with semiconductor and printed-circuit-board substrates. Aligned composites with estimated SrM particle volume percentages of 14 vol.%, 20 vol.%, and 27 vol.% are fabricated, as well as an unaligned 14 vol.% composite for comparison. X-ray diffraction (XRD) and scanning electron microscopy (SEM) are used to examine the structure and composition of the composites. Furthermore, vibrating sample magnetometer and ferromagnetic resonance (FMR) measurements are performed to determine their dc and ac magnetic properties. Results show that the aligned composites have magnetic textures between 1.47 and 1.95, crystalline anisotropies between 1860 and 1960 kA/m, FMR frequencies of 45.5–45.9 GHz, and FMR linewidths between 3400 and 3500 Oe, indicating the potential for these materials in self-biased, non-reciprocal device applications. The analysis identifies that increased particle loading and better particle alignment may further improve these films by decreasing the linewidth.
Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria (2001)

The infection of biomaterials is determined by an interplay of adhesion and surface growth of the infecting organisms. In this study, the antimicrobial effects on adhering bacteria of a positively charged poly(methacrylate) surface (xi potential +12 mV) were compared with those of negatively charged poly(methyl methacrylate) (-12 mV) and a highly negatively charged poly(methacrylate) (-18 mV) surface. Initial adhesion of Staphylococcus aureus ATCC 12600, Staphylococcus epidermidis HBH(2) 102, Escherichia coli O2K2 and Pseudomonas aeruginosa AK1 to these surfaces was measured in a parallel plate flow chamber in phosphate-buffered saline. Adhering bacteria were allowed to multiply by perfusing the flow chamber with growth medium. All bacteria adhered most rapidly to the positively charged surface, but there was no subsequent surface growth of the Gram-negative strains. On the negatively charged surfaces, despite a slower initial adhesion, surface growth of the adhering bacteria was exponential for both Gram-positive and Gram-negative strains. These results suggest that positively charged biomaterial surfaces exert an antimicrobial effect on adhering Gram-negative bacteria, but not on Gram-positive ones.
Development of highly transparent seedless ZnO nanorods engineered for inverted polymer solar cells (2014)

This work reports on inverted polymer solar cells (IPSCs) based on highly transparent (>95%), hydrophobic, seedless ZnO nanorods (NRs) as cathode buffers with extremely enhanced electrical characteristics. The transparent NR suspension with stability for more than a year is achieved by adding a small amount of 2-(2-methoxyethoxy) acetic acid (MEA). The ability of the stable nanorod suspension to easily spin-coat is certainly an advance to the fabrication of films over large areas and to replace the conventional seeding method to grow one-dimensional nanostructures for use in optoelectronic devices. We observe a strong correlation between the photovoltaic performance and the transparency of ZnO NRs. IPSCs using poly-3-hexylthiophene (P3HT) and [6,6]-phenyl C60 butyric acid methyl ester (PCBM) mixtures in the active layer and transparent (MEA-capped) ZnO NRs as cathode buffers exhibit a power conversion efficiency of 3.24% under simulated AM 1.5G, 100 mW cm(-2) illumination.
Secure multi-party data communications in cloud augmented IoT environment (2017)

In concert with advances of wireless technologies in facilitating internet connectivity of Internet of Things (IoT) devices, mobile edge computing can provision and distribute computing resources at the cloudlets to efficiently process a high volume of IoT data. Among the IoT applications, multi-party data sharing among IoT devices, wireless access nodes and cloudlets is becoming increasingly critical, not only because the data collected by each single IoT device will often stay unmined, but also because of the security concern. As IoT applications' dependence on the cloud environment grows, the rich resources at cloudlets often become the attack targets, and the IoT data that are stored or processed using the cloud resources will be jeopardized. For the internet of important things, we have investigated how to efficiently and securely share the data among multi-party. In particular, for a group of cooperative IoT devices, by leveraging the cloud resources available at the wireless access points, a secure cache site with fast data uploading rate is chosen for each user. To minimize the overall data downloading time, the multi-party multi-path data delivery scheme is also designed such that each user can efficiently retrieve the data belonging to other parties.
Récepteurs de Wiener Optimaux et Sous Optimaux à Rang Réduit pour le CDMA, Algorithmes et Performances (2005)

Dans cette thèse, les récepteurs de Wiener optimaux et sous-optimaux à rang réduit pour le CDMA sont étudiés. La thèse est divisée en deux partie. Dans la première partie, les récepteurs sous-optimaux consisant d'un égaliseur de Wiener à rang réduit au rythme chip suivi de desétalement sont étudiés. Un égaliseur à rang réduit est un égaliseur pour lequel quelques coefficients seulement sont optimisés. Le rang du filtre est le nombre de coefficient optimisés. Dans la deuxième partie, la performance asymptotique de quelques récepteurs linéaires est evaluée. Pour étudier la performance asymptotique, on suppose que les codes d'étalement sont aléatoires suivant une certaine distribution. Le rapport Signal à Interference plus Bruit (SINR) à la sortie du récepteur peut ainsi être interprété comme une variable aléatoire. Il est possible de démontrer que ces variables aléatoires tendent vers des valeurs deterministes finies quand le facteur d'étalement et le nombre d'utilisateurs tendent vers l'infini de telle façon que leur rapport reste fini. Ces limites peuvent être utilisées pour comprendre les facteurs qui controlent la performance tels que le canal de propagation, le bruit et le facteur de charge. On présente les résultats précédents relatifs au récepteurs de Wiener optimaux à rang réduit. Ces résultats sont après étendus au récepteurs de Wiener sous-optimaux à rang réduit.On démontre que la convergence du SINR d'un récepteur de Wiener à rang réduit vers celui du récepteur à rang plein est très rapide. Dans le dernier chapitre, on étudie la performance asymptotique de la diversité à la transmission combinée avec un récepteur RAKE où un égaliseur MMSE.
Demonstration of holes in strained Ge quantum wells with much higher drift mobility and density than that of electrons in strained Si channels (2007)

2007 International Conference on Solid State Devices and Materials,Demonstration of holes in strained Ge quantum wells with much higher drift mobility and density than that of electrons in strained Si channels
Abstract 16717: Customizable High-density Microelectrode Arrays for Murine Cardiac Electrophysiology (2016)

Introduction: Mouse models offer robust approaches to study cardiac physiology and pathophysiology in part due to the ability to manipulate their genome. Traditional methods for recording murine cardiac electrophysiologic (EP) data involve electrocardiograms and small catheters in vivo which provide limited spatial resolution, or optical mapping ex vivo which requires electromechanical uncoupling. Objective: To develop high-density microelectrode arrays for high-fidelity, high-resolution recording of murine cardiac EP data. Methods & Results: We have developed high-density microelectrode arrays for recording unipolar electrocardiograms and pacing from the epicardial surface of the murine heart (Fig. 1A). These arrays are composed of a thin-film polymer with a grid of addressable electrode sites. The highly flexible polymer substrate maintains conformal contact with the heart as it beats. The design space for the arrays include grid dimensions from approximately 200 μm to 8 cm and 16 to 512 electrodes, wit...
Enantioselective enzymatic reduction of prochiral ketones in one-phase and two-phase systems (2010)

Within this thesis a strategy for the enantioselective synthesis of chiral short chain alcohols using biocatalysis is developed. This is realized in close collaboration with an industrial partner. The biocatalysts used are alcohol dehydrogenases (ADH) which need nicotinamide cofactors (NAD+/NADH and NADP+/NADPH) as redox equivalents. The regeneration of the cofactors is done substrate dependent by addition of 2-propanol which is oxidized by the ADH while the cofactor is reduced, and enzyme dependent. Here, a malate dehydrogenase(MDH) as second enzyme and L-malic acid as specific substrate are used for in situ cofactor reduction. The kinetic characterization of the different ADH preparations and of a NAD- and a NADP-dependent MDH shows strong dependence of activity on the substrate, on reaction parameters like concentrations of buffer, substrate, and cofactor, on the type of ADH and on the kind of preparation, i.e. lyophilized or purified. The obtained results are transferred to one-phase batch synthesis of (R)- and (S)-2-butanol. Conversion and enantioselectivity (ee) are dependent on reaction conditions, i.e. 2-propanol and substrate concentration. Generally it is possible to synthesis both enantiomers of 2-butanol in the one-phase system. Due to limitations like low conversion, low selectivity, and low substrate solubility the synthesis of (R)-2-butanol is transferred to two-phase reaction systems using methyl-tert-butyl ether(MTBE) and the tailor-made ionic liquid (IL) as non-reactive phase. MTBE turns out to be the solvent of choice. Depending on substrate and co-substrate concentration conversion and ee can be positively influenced. The same is found for two-phase reactions with MTBE in a continuous reaction set-up. With the optimum reaction conditions obtained from the batch experiments conversion and ee are improved. Another influencing factor in the continuous reaction is the flow rate. ADH and cofactor show exceptionally high stability and high TTN. Together with further development of a work-up strategy the continuous two-phase reaction set-up will be a strong tool to produce enantiopure alcohols on preparative relevant scale.
Continuous Renal Replacement Therapy: Does Technique Influence Electrolyte and Bicarbonate Control? (2003)

CRRT strategies based on different techniques have a significantly different impact on sodium and bicarbonate control.
Photooxygenation of alkanes by dioxygen with p-benzoquinone derivatives with high quantum yields (2016)

Alkanes were oxygenated by dioxygen with p-benzoquinone derivatives such as p-xyloquinone in alkanes which are used as solvents to yield the corresponding alkyl hydroperoxides, alcohols and ketones under visible light irradiation with high quantum yields (Φ = 1000, 1600%). The photooxygenation is started by hydrogen atom abstraction from alkanes by the triplet excited states of p-benzoquinone derivatives as revealed by laser-induced transient absorption spectral measurements.
A20 Restrains Thymic Regulatory T Cell Development (2017)

Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (T<sub>reg</sub>) cells in the thymus. Activation of NF-κB transcription factors is critically required for T<sub>reg</sub> cell development, partly via initiating Foxp3 expression. NF-κB activation is controlled by a negative feedback regulation through the ubiquitin editing enzyme A20, which reduces proinflammatory signaling in myeloid cells and B cells. In naive CD4<sup>+</sup> T cells, A20 prevents kinase RIPK3-dependent necroptosis. Using mice deficient for A20 in T lineage cells, we show that thymic and peripheral T<sub>reg</sub> cell compartments are quantitatively enlarged because of a cell-intrinsic developmental advantage of A20-deficient thymic T<sub>reg</sub> differentiation. A20-deficient thymic T<sub>reg</sub> cells exhibit reduced dependence on IL-2 but unchanged rates of proliferation and apoptosis. Activation of the NF-κB transcription factor RelA was enhanced, whereas nuclear translocation of c-Rel was decreased in A20-deficient thymic T<sub>reg</sub> cells. Furthermore, we found that the increase in T<sub>reg</sub> cells in T cell-specific A20-deficient mice was already observed in CD4<sup>+</sup> single-positive CD25<sup>+</sup> GITR<sup>+</sup> Foxp3<sup>-</sup> thymic T<sub>reg</sub> cell progenitors. T<sub>reg</sub> cell precursors expressed high levels of the tumor necrosis factor receptor superfamily molecule GITR, whose stimulation is closely linked to thymic T<sub>reg</sub> cell development. A20-deficient T<sub>reg</sub> cells efficiently suppressed effector T cell-mediated graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, suggesting normal suppressive function. Holding thymic production of natural T<sub>reg</sub> cells in check, A20 thus integrates T<sub>reg</sub> cell activity and increased effector T cell survival into an efficient CD4<sup>+</sup> T cell response.