gebhart/patrepeval huggingface dataset:
A 43-Gb/s full-rate-clock 4:1 multiplexer in InP-based HEMT technology (2002)

This paper describes a full-rate-clock 4:1 multiplexer (MUX) in a 0.13-/spl mu/m InP-based HEMT technology for 40-Gb/s and above optical fiber link systems. To reduce output jitter, the serialized data are retimed at the final stage by a retimer, a D-type flip-flop, which has a symmetric layout with an optimized spacing to the ground that minimizes coupling capacitances. A phase adjuster, composed of an exclusive OR and a delay switch, uses external control signals to change each phase of the serialized data and clock entering the retimer and gives a correct timing for the clock to drive the retimer. A clock distributor with a simple wired splitter divides the clock into two clocks with high gain and low current. The MUX integrates 1355 HEMTs formed using electron beam lithography. A chip mounted in a test module operated at up to 47 Gb/s with a power consumption of 7.9 W for a single supply voltage of -5.2 V.
Functional Assessment of the Engraftment Potential of Gammaretrovirus-Modified CD34 + Cells, Using a Short Serum-Free Transduction Protocol (2006)

The successful transduction and engraftment of human mobilized peripheral blood (MBP) CD34(+) cells are determined to a large extent by the ex vivo cell-processing conditions. In preparation for upcoming clinical trials, we investigated essential culture parameters and devised a short and efficient gammaretroviral transduction protocol entailing minimal manipulation of MBP CD34(+) cells. The engraftment potential and in vivo transgene expression in the progeny of repopulating CD34(+) cells were measured to assess the functionality of CD34(+) cells transduced under these conditions. Using a competitive in vivo repopulation assay in nonobese diabetic/severe combined immunodeficient mice, we demonstrate equivalent engraftment of CD34(+) cells transduced under serum-free conditions as compared with CD34(+) cells cultured with serum. We also took advantage of this in vivo model to demonstrate that ex vivo manipulation of CD34(+) cells can be shortened to 60 hr, using 36 hr of prestimulation and two cycles of transduction 12 hr apart. These minimally manipulated CD34(+) cells engraft in a manner similar to cells transduced under longer protocols and the vector-encoded transgene is expressed at the same frequency in cells derived from repopulating CD34(+) cells in vivo. We have thus developed a short and efficient human MBP CD34(+) transduction protocol under serum-free conditions that is suitable and broadly applicable for phase I clinical trials.
Hybrid Monte Carlo Method for Simulation of Two-ComponentAerosol Coagulation and Phase Segregation (1903)

The paper presents the development of a hybrid Monte Carlo (MC) method for the simulation of the simultaneous coagulation and phase segregation of an immiscible two-component binary aerosol. The model is intended to qualitatively model our prior studies of the synthesis of mixed metal oxides for which phasesegregated domains have been observed in molten nanodroplets. In our previous works (J. Aerosol Sci. 32, 1479 (2001); Chem. Eng. Sci. 56, 5763 (2001); submitted for publication) we developed sectional and monodisperse models where the internal state of the aerosol particles was described. These methods have certain limitations and it is difficult to include additional physical effects into the framework. Our new approach combines both constant volume and constant number Monte Carlo methods. Similar to our previous models, we assume that the phase segregation is kinetically controlled. The MC approach allows us to compute the mean number of enclosures (minor phase) per droplet, average enclosure volume, and the width of the enclosure size distribution. The results show that asymptotic behavior of enclosure distribution exists that is independent of initial conditions, which is very close to the continuum selfpreserving distribution. Temperature is a key parameter because it allows for a significant change in the internal transport rate within each droplet. In particular, increasing the temperature significantly enhances the Brownian coagulation rate and lowers the number of enclosures per droplet. As a result, the MC results indicate that the growth of the minor phase can be moderated quite dramatically by small changes in system temperature. These results serve to illustrate the utility of this synthesis approach to the controlled growth of nanoparticles through the use of a majority matrix to slow down the encounter frequency of the minor phase and therefore its particle size. C © 2002 Elsevier Science (USA)
Coexistence of Regular Undamped Nuclear Dynamics with Intrinsic Chaoticity (1994)

We study the conditions under which the nucleons inside a deformed nucleus can undergo chaotic motion. To do this we perform self-consistent calculations in semiclassical approximation utilizing a multipole-multipole interaction of the Bohr-Mottelson type for quadrupole and octupole deformations. For the case of harmonic and nonharmonic static potentials, we find that both multipole deformations lead to regular motion of the collective coordinate, the multipole moment of deformation. However, despite this regular collective motion, we observe chaotic single-particle dynamics.
Solution-Blown Poly(hydroxybutyrate) and ε-Poly-l-lysine Submicro- and Microfiber-Based Sustainable Nonwovens with Antimicrobial Activity for Single-Use Applications (2021)

Antimicrobial nonwovens for single use applications (e.g., diapers, sanitary napkins, medical gauze, etc.) are of utmost importance as the first line of defense against bacterial infections. However, the utilization of petrochemical nondegradable polymers in such nonwovens creates sustainability-related issues. Here, sustainable poly(hydroxybutyrate) (PHB) and ε-poly-l-lysine (ε-PLL) submicro- and microfiber-based antimicrobial nonwovens produced by a novel industrially scalable process, solution blowing, have been proposed. In such nonwovens, ε-PLL acts as an active material. In particular, it was found that most of ε-PLL is released within the first hour of deployment, as is desirable for the applications of interest. The submicro- and microfiber mat was tested against <i>C. albicans</i> and <i>E. coli</i>, and it was found that ε-PLL-releasing microfibers result in a significant reduction of bacterial colonies. It was also found that ε-PLL-releasing antimicrobial submicro- and microfiber nonwovens are safe for human cells in fibroblast culture. Mechanical characterization of these nonwovens revealed that, even though they are felt as soft and malleable, they possess sufficient strength, which is desirable in the end-user applications.
Rapid screening for asymmetric catalysts: the efficient connection of two different catalytic asymmetric reactions (2009)

A screening method for asymmetric catalysts is reported in which a metal-containing optically-active product of an asymmetric reaction is employed as a chiral catalyst in another asymmetric reaction; the rapid preparation and instant testing system of catalysts resulted in a considerable reduction in the time required for the screening process.
Identification of catecholamines in the immune system by electrospray ionization mass spectrometry (1998)

The first evidence that catecholamines might be present in the immune system was provided by capillary electrophoresis combined with electrochemical detection. Here, we present the first structural characterization of the endogenous catecholamines isolated from human peripheral blood mononuclear cells. Dopamine, L-DOPA and norepinephrine were detected and were identified with electrospray ionization mass spectrometry by determination of the protonated molecular species of each catecholamine and their major fragments generated in the electrospray source with a nozzle-skimmer voltage method. This technique, in conjunction with accurate mass measurement, allowed us to identify in an unfractionated sample the content of catecholamines in extracted cells in a quantitative manner, with structure-specific methodology. The data unambiguously confirm our previous tentative findings, and also strengthen the importance of the regulatory function of catecholamines in the immune system and the existence of an autocrine loop, where lymphocytes may down-regulate their own activity.
Robustness Metric for Quantifying Causal Model Confidence and Parameter Uncertainty (2016)

Many methods of estimating causal models do not provide estimates of confidence in the resulting model. In this work, a metric is proposed for validating the output of a causal model fit; the robustness of the model structure with resampled data. The metric is developed for time series causal models, but is also applicable to non-time series data. The proposed metric may be utilized regardless of the method selected for fitting the causal model. We find that with synthetically generated data, this metric is able to successfully identify the true data generating model in most cases. Additionally, the metric provides both a qualitative measure of model confidence represented by the robustness level as well as accurate estimates of uncertainty in model coefficients which are important in interpreting model results. The use of this metric is demonstrated on both numerically simulated data and a case study from existing causal model literature.
Ham quality control by means of fuzzy decision trees: a case study (2002)

Lean muscle color strongly influences consumer impressions of quality. A bright-reddish pork is sought as an ideal; some variation of color is normal as can be observed if different pork muscles are considered. However, muscle color changes quite easily, and as a result can be indicative of meat quality. Assessment of meat quality is crucial both in cooked ham and raw ham processing plants. A good meat classification system should allow porks of uniform meat to be processed in a uniform way. This would result in a uniform parcel of ham (cooked or raw) and reduce cost and rejects. We present a classification methodology of fresh pork meat based on computer vision color analysis techniques and fuzzy decision trees. The discussed methodology has been tested on site and the obtained classifications have been compared with human experts' ratings giving interesting results.
Drop dynamics in microgravity (1997)

The dynamics of liquid drops in microgravity were observed in the Drop Physics Module flown aboard the second United States Microgravity Laboratory (USML-2) in 1995. Water drops with varying concentrations of the surfactants Triton-X 100 and Bovine Serum Albumin were suspended in air and deformed by an acoustic standing wave. When the deforming force was removed, the drops oscillated freely about a spherical equilibrium shape, as opposed to the oblate equilibrium shape of a drop levitated in 1-g. Drop diameters between 1 and 3 cm were observed. Frequencies and decays for the dynamics have been extracted from the data. Results are compared to theoretical models and experiments in 1-g. Results for frequency shifts due to large amplitude oscillations are also presented. [Work supported by NASA through JPL, contract 958722.]
Compact and voltage-scalable sensor for accurate thermal sensing in dynamic thermal management (2017)

Today's microprocessors and Systems-on-Chip are thermally limited. Many, therefore, employ dynamic thermal management (DTM) to maximize performance under a reliability constraint. Accurate thermal monitoring is critical as temperature underestimation can hurt reliability by excessively aging devices and overestimation can hurt performance by unnecessarily throttling computing components. Placing temperature sensors close to potential hotspots can help accuracy, but it is non-trivial as hotspots often form inside digital blocks consisting of densely placed digital cells. Large sensors can disrupt cell placement thereby increasing wire lengths and circuit delays. Furthermore, the sensor needs to operate from the same digital power grid as the circuit, one that can be scaled down to near-threshold regime via dynamic voltage scaling. Absent this ability, a separate power grid and dedicated supply voltage for the sensors further increases area overhead. In this paper, we present a sensor circuit that is compact and deeply voltage-scalable and can be embedded among digital cells with little disruption. Simulation results show that it achieves a comparable accuracy to other compact sensor circuits for DTM.
ChemInform Abstract: Radical Addition to Iminium Ion Mediated by Aqueous Titanium Trichloride. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Relative movement evaluation between developed distributed-type tactile sensor and the contacting object (2005)

This paper describes an output algorithm that measures forces and moment acting on a developed distributed-type tactile sensor and evaluates relative movement with the contacting object. To realize advanced manipulation, it is necessary to acquire forces and moments acting on the fingertips of the robot hand; it is also necessary to evaluate the relative movement between the contacting object and the sensor. An output algorithm for evaluating the relative movement for developed tactile sensor was created whose effectiveness was shown by experiments.
MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis (2020)

Among patients with MRI-visible lesions, combined biopsy led to more detection of all prostate cancers. However, MRI-targeted biopsy alone underestimated the histologic grade of some tumors. After radical prostatectomy, upgrades to grade group 3 or higher on histopathological analysis were substantially lower after combined biopsy. (Funded by the National Institutes of Health and others; Trio Study ClinicalTrials.gov number, NCT00102544.).
Exploring Temporal Granularity in Self-Supervised Video Representation Learning (2021)

This work presents a self-supervised learning framework named TeG to explore Temporal Granularity in learning video representations. In TeG, we sample a long clip from a video and a short clip that lies inside the long clip. We then extract their dense temporal embeddings. The training objective consists of two parts: a fine-grained temporal learning objective to maximize the similarity between corresponding temporal embeddings in the short clip and the long clip, and a persistent temporal learning objective to pull together global embeddings of the two clips. Our study reveals the impact of temporal granularity with three major findings. 1) Different video tasks may require features of different temporal granularities. 2) Intriguingly, some tasks that are widely considered to require temporal awareness can actually be well addressed by temporally persistent features. 3) The flexibility of TeG gives rise to state-of-the-art results on 8 video benchmarks, outperforming supervised pre-training in most cases.
A hip–knee–ankle exoskeleton emulator for studying gait assistance (2020)

Lower-limb exoskeletons could improve the mobility of people with disabilities, older adults, workers, first responders, and military personnel. Despite recent advances, few products are commercially available and exoskeleton research is still often limited by hardware constraints. Many promising multi-joint assistance strategies, especially those with high-torque and high-power components, have yet to be tested because they are beyond the capabilities of current devices. To study these untested assistance strategies, we present a hip–knee–ankle exoskeleton emulator that can apply high torques and powers that match or exceed those observed in uphill running. The system has powerful off-board motors that actuate a 13.5 kg exoskeleton end effector worn by the user. It can apply up to 200 Nm of torque in hip flexion, hip extension, and ankle plantarflexion, 250 Nm of torque in knee extension, and 140 Nm of torque in knee flexion, with over 4.5 kW of power at each joint and a closed-loop torque bandwidth of at least 18 Hz in each direction of actuation. The exoskeleton is compliant in unactuated directions, adjustable for a wide range of users and comfortable during walking and running. When paired with human-in-the-loop optimization, we expect that this system will identify new assistance strategies to improve human mobility. A complete computer-aided design (CAD) model of the exoskeleton and a bill of materials are included and available for download.
A Growth-suppressive Function for the c-Fes Protein-Tyrosine Kinase in Colorectal Cancer (2006)

The human c-fes locus encodes a non-receptor protein-tyrosine kinase implicated in myeloid, vascular endothelial, and neuronal cell differentiation. A recent analysis of the tyrosine kinome in colorectal cancer identified c-fes as one of only seven genes with consistent kinase domain mutations. Although four mutations were identified (M704V, R706Q, V743M, S759F), the consequences of these mutations on Fes kinase activity were not explored. To address this issue, Fes mutants with these substitutions were co-expressed with STAT3 in human 293T cells. Surprisingly, the M704V, R706Q, and V743M mutations substantially reduced Fes autophosphorylation and STAT3 Tyr-705 phosphorylation compared with wild-type Fes, whereas S759F had little effect. These mutations had a similar impact on Fes kinase activity in a yeast expression system, suggesting that they inhibit Fes by affecting kinase domain structure. We have also demonstrated for the first time that endogenous Fes is strongly expressed at the base of colonic crypts where it co-localizes with epithelial cells positive for the progenitor cell marker Musashi-1. In contrast to normal colonic epithelium, Fes expression was reduced or absent in colon tumor sections from most individuals. Fes protein levels were also low or absent in a panel of human colorectal cancer cell lines, including HT-29 and HCT 116 cells. Introduction of Fes into these lines with a recombinant retrovirus suppressed their growth in soft agar. Together, our findings strongly implicate the c-Fes protein-tyrosine kinase as a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing (2022)

Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on LNP surfaces, PEGylated lipids (PEG-lipids) play an important role in defining LNP physicochemical properties and biological interactions. Previous studies indicate that LNP performance is modulated by tuning PEG-lipid parameters including PEG size and architecture, carbon tail type and length, as well as the PEG-lipid molar ratio in LNPs. Owing to these numerous degrees of freedom, a high-throughput approach is necessary to fully understand LNP behavioral trends over a broad range of PEG-lipid variables. To this end, we report a low-volume, automated, high-throughput screening (HTS) workflow for the preparation, characterization, and <i>in vitro</i> assessment of LNPs loaded with a therapeutic antisense oligonucleotide (ASO). A library of 54 ASO-LNP formulations with distinct PEG-lipid compositions was prepared using a liquid handling robot and assessed for their physiochemical properties as well as gene silencing efficacy in murine cortical neurons. Our results show that the molar ratio of anionic PEG-lipid in LNPs regulates particle size and PEG-lipid carbon tail length controls ASO-LNP gene silencing activity. ASO-LNPs formulated using PEG-lipids with optimal carbon tail lengths achieved up to 5-fold lower mRNA expression in neurons as compared to naked ASO. Representative ASO-LNP formulations were further characterized using dose-response curves and small-angle X-ray scattering to understand structure-activity relationships. Identified hits were also tested for efficacy in primary murine microglia and were scaled-up using a microfluidic formulation technique, demonstrating a smooth translation of ASO-LNP properties and <i>in vitro</i> efficacy. The reported HTS workflow can be used to screen additional multivariate parameters of LNPs with significant time and material savings, therefore guiding the selection and scale-up of optimal formulations for nucleic acid delivery to a variety of cellular targets.
TouchLens: touch enhancing tool (2005)

Here we show a touch-enhancing tool that operates not only as a disturbance filter, but also, supposedly, as a magnifier of surface undulation. This tool, which we named "TouchLens," is composed of a sheet and numerous pins regularly arranged on one side of the sheet, having no electronic or mechatronic components. The most promising application of TouchLens is its use in inspection of sheet metals to detect small deflection defects and skill transfer in automobile industry.
Auto-tandem catalytic reductive hydroformylation with continuous multiphase catalyst recycling (2021)

This work covers auto-tandem catalytic hydroformylation and hydrogenation for the synthesis of alcohols for synthetic fuels from renewable olefin cuts. A multiphase catalyst recycling system was proven to be feasible in continuous flow.
ChemInform Abstract: High‐Throughput Approaches to Homogeneous Catalysis. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancement of Gear Fault Detection Using Narrowband Interference Cancellation (2013)

The development of enhanced fault detection ability for gearbox systems has received considerable attention in recent years. Detecting the gear fault easier is very important for maintenance action. This has driven the need in research for enhanced gear fault detection method. The goal is to extract periodic impulse signal from the very noise signal which mainly contains the narrowband signals. This can be done by enhancing the impulsive signals while suppressing the narrowband signals. This paper used a new method, Narrowband Interference Cancellation, to detect the gear fault. This method reserves the impulsive signal produced by gear fault and removes the other signals out. The methodology is demonstrated on a gearbox run-to-failure test. The results show that Narrowband Interference Cancellation can enable the gear fault detection easier.
A wafer-level heterogeneous technology integration for flexible pseudo-SoC (2010)

The MEMS-LSI integration technologies that have been reported are mainly implemented for monolithic integrated System on Chip (SoC) by applying the advantages of process compatibility between MEMS and CMOS LSI [1]. However, it has been impossible to integrate them in the case that MEMS and standard CMOS processes are incompatible. Furthermore, many MEMS-LSI integration technologies applying System in Package (SiP) technology with the interposer substrate to realize electronics devices have been reported. However, using SiP technology, it has not been possible to achieve high integration density comparable to that of monolithic integrated SoC because the interposer substrate occupies a large area in SiP. Accordingly, development of an advanced MEMS-LSI integration technology to realizing highly integrated SoC incorporating MEMS devices is required [2].