gebhart/patrepeval huggingface dataset:
Providing User Security Guarantees in Public Infrastructure Clouds (2016)

The infrastructure cloud (IaaS) service model offers improved resource flexibility and availability, where tenants - insulated from the minutiae of hardware maintenance - rent computing resources to deploy and operate complex systems. Large-scale services running on IaaS platforms demonstrate the viability of this model; nevertheless, many organizations operating on sensitive data avoid migrating operations to IaaS platforms due to security concerns. In this paper, we describe a framework for data and operation security in IaaS, consisting of protocols for a trusted launch of virtual machines and domain-based storage protection. We continue with an extensive theoretical analysis with proofs about protocol resistance against attacks in the defined threat model. The protocols allow trust to be established by remotely attesting host platform configuration prior to launching guest virtual machines and ensure confidentiality of data in remote storage, with encryption keys maintained outside of the IaaS domain. Presented experimental results demonstrate the validity and efficiency of the proposed protocols. The framework prototype was implemented on a test bed operating a public electronic health record system, showing that the proposed protocols can be integrated into existing cloud environments.
The importance of monitoring adverse drug reactions in pediatric patients: the results of a national surveillance program in Italy (2014)

The MEAP project demonstrated that active post-marketing pharmacovigilance programs are a valid strategy to increase awareness on pediatric pharmacology, reduce underreporting and provide information on drug actions in pediatrics. This information enhances drug therapy optimization in the pediatric patients.
Assessing Disease Exposure Risk With Location Histories And Protecting Privacy: A Cryptographic Approach In Response To A Global Pandemic (2020)

Governments and researchers around the world are implementing digital contact tracing solutions to stem the spread of infectious disease, namely COVID-19. Many of these solutions threaten individual rights and privacy. Our goal is to break past the false dichotomy of effective versus privacy-preserving contact tracing. We offer an alternative approach to assess and communicate users' risk of exposure to an infectious disease while preserving individual privacy. Our proposal uses recent GPS location histories, which are transformed and encrypted, and a private set intersection protocol to interface with a semi-trusted authority. There have been other recent proposals for privacy-preserving contact tracing, based on Bluetooth and decentralization, that could further eliminate the need for trust in authority. However, solutions with Bluetooth are currently limited to certain devices and contexts while decentralization adds complexity. The goal of this work is two-fold: we aim to propose a location-based system that is more privacy-preserving than what is currently being adopted by governments around the world, and that is also practical to implement with the immediacy needed to stem a viral outbreak.
Abstract 3940: Inactivation of the PARD3 gene is a recurrent event in lung squamous cell carcinomas and affects STAT3 activity and tumor invasiveness (2015)

Abstract Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the partitioning defective 3 gene, PARD3, to the carcinogenesis of lung squamous cell carcinomas (LSCCs). Tumor-specific PARD3 alterations were found in eight per cent of the tumors, placing PARD3 among the most common tumor suppressor genes in LSCC. Some PAR3 mutant proteins prevented the formation of contacts between neighboring cells, i.e. had reduced ability to form tight junctions and actin-based protrusions. This affected subsequent downstream signaling, i.e. binding to aPKC and activation of RAC1. Further, we discovered that PAR3 wild type triggered the expression of cell adhesion and polarity-related transcripts and the activation of STAT3, by cell confluence. Finally, restitution of PAR3 in vivo significantly reduced the formation of metastasis. In conclusion, PARD3 is recurrently inactivated in LSCC and its deficiency contributes to the tumor aggressiveness. Citation Format: Ester Bonastre, Sara Verdura, Ilse Zondervan, Federica Facchinetti, Sylvie Lantuejoul, Maria Dolores Chiara, Juan Pablo Rodrigo, Julian Carretero, David Sidransky, Alberto Villanueva, Enric Condom, Agustin Vidal, Luca Roz, Elisabeth Brambilla, Suvi Savola, Montse Sanchez-Cespedes. Inactivation of the PARD3 gene is a recurrent event in lung squamous cell carcinomas and affects STAT3 activity and tumor invasiveness. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3940. doi:10.1158/1538-7445.AM2015-3940
Axially Symmetric Magnetic Mirrors: History of Development and Future Prospects (2013)

The paper reviews the milestones in development of axially symmetric magnetic mirrors for plasma confinement. In particular, future prospects of the multi-mirror confinement system and gas-dynamic trap as neutron sources and drivers for fission-fusion hybrids are considered. An emphasis is made on discussion of current status of experimental studies on the GOL-3 and GDT devices in Novosibirsk.
Organolanthanide-Catalyzed Hydroamination/Cyclization Reactions of Aminoalkynes. Computational Investigation of Mechanism, Lanthanide Identity, and Substituent Effects for a Very Exothermic C−N Bond-Forming Process (2006)

This contribution focuses on organolanthanide-mediated catalytic hydroamination processes and analyzes the exothermic hydroamination/cyclization of a prototypical aminoalkyne, H2N(CH2)3C⋮CR, mediated by Cp2Sm− complexes, using density functional theory. The reaction is found to proceed in two discrete steps, namely, cyclization with concerted Ln−C and C−N bond formation and subsequent Ln−C protonolysis. Dissociation of the cyclized amine then follows to regenerate the active catalyst. Analysis is carried out for (i) insertion of the triple bond moiety into the Sm−N bond via a four-center transition state, (ii) subsequent Sm−C protonolysis by a second substrate molecule, (iii) the effects of other Ln+3 ions and aminoalkyne R substituents on the reaction energetics, and (iv) comparison to the analogous, essentially thermoneutral process for aminoalkenes. DFT energetic profiles are computed for the turnover-limiting aminoalkyne C⋮C triple bond insertion into the Ln−NH− linkage, and the geometries and stabilities of reactants, intermediates, and products are analyzed. The picture that emerges involves concerted, rate-limiting, exothermic insertion of the alkyne fragment into the Ln−N(amido) bond via a highly organized, seven-membered chairlike cyclic transition state (ΔH⧧calcd = 4.6 kcal/mol, ΔS⧧calcd = −11.9 eu). The resulting cyclized complex then undergoes exergonic protonolysis to yield an amine−amido complex, the likely resting state of the catalyst. Large rate accelerations effected by smaller lanthanide ions and certain alkyne substituents can be understood in terms of approach distances and charge buildup in the cyclization transition state.
Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins (2009)

The synthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins are reported. A general synthetic protocol, based on "C-5 camptothecin (C-5-CPT) enolate chemistry", allows one to obtain various C5-substituted analogues. All new compounds, obtained as 1:1 epimeric mixtures, were tested for their antiproliferative activity. Experimental data showed that all novel derivatives are less active than the reference compounds and that one of the two epimers is more active than the other. Molecular docking simulations were performed to achieve more insight into the interactions between the new C5-modified CPTs and Topo I. A good correlation was observed when the data of cytotoxicity and the values calculated for the free binding energy were combined.
Investigation of quantum dot enhanced triple junction solar cells (2011)

InAs quantum dots have been incorporated into the middle junction of an InGaP/(In)GaAs/Ge triple junction solar cell (TJSC) on four inch wafers, in aims of band gap engineering a high efficiency solar cell to even higher limits. Results of QD growth on 4” diameter Ge templates gave densities near 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> and QD height between 2-5 nm. Arrays of 10 layers of InAs QDs have been grown between the base and emitter in the middle cell of a full triple junction solar cell. Control triple junction cells that received growth interrupts without QD growth showed similar results (within 5 mV open circuit voltage) to standard triple junction cells without an interrupt. Integrated current of the (In)GaAs junction with 10 layers of strain balanced InAs QD layers shows a gain of 0.37 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> beyond the band edge. One sun AM0 current-voltage measurements of QD TJSC show an efficiency of 26.9% with a Voc of 2.57 V.
Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging (2013)

Fluorescence labeled biomarkers can be detected during endoscopy to guide early cancer biopsies, such as high-grade dysplasia in Barrett's Esophagus. To enhance intraoperative visualization of the fluorescence hot-spots, a mosaicking technique was developed to create full anatomical maps of the lower esophagus and associated fluorescent hot-spots. The resultant mosaic map contains overlaid reflectance and fluorescence images. It can be used to assist biopsy and document findings. The mosaicking algorithm uses reflectance images to calculate image registration between successive frames, and apply this registration to simultaneously acquired fluorescence images. During this mosaicking process, the fluorescence signal is enhanced through multi-frame averaging. Preliminary results showed that the technique promises to enhance the detectability of the hot-spots due to enhanced fluorescence signal.
WFA blocks activation of the ERK1/2 pathway <i>in vivo</i> by targeting pSer38vim expression. (2015)

&lt;p&gt;Anesthetized mice were subjected to bilateral corneal alkali injury. Injured mice were treated with DMSO (Vehicle) or WFA (2 mg/kg solubilized in DMSO) on the day of injury and every subsequent day by intraperitoneal injection for 14 days. (A) Immunohistochemistry analysis of WT corneal sections stained with pSer38vim antibody (red) and DAPI (blue). Epi: Epithelium; Str: Stroma; End: Endothelium. Enlarged panels: 60X magnification. (B) Immunohistochemistry analysis of WT and Vim KO samples stained with anti-pERK1/2 antibody (Green) and DAPI (blue). Enlarged panel: 60X magnification of WT-Vehicle sample, showing nuclear expression pERK1/2 (Green). Pointed-ended arrows indicate nuclear localization of pERK1/2 in epithelial and stromal cells of WT-Vehicle samples. Square-ended arrow indicates cytoplasmic localization of pERK1/2 in the basal layer of the epithelium of WT-WFA samples. Arrowhead indicates partial cytoplasmic localization of pERK1/2 in stromal cells of Vim KO-Vehicle samples. (C) Western blot analysis of epithelial and stromal extracts from corneas of mice 14 d post-injury. Equal amount of total protein extracts were fractionated by SDS-PAGE and blots were probed with anti-pERK1/2 antibody. β-tubulin was used as loading control. (D) Western blot analysis of corneal extracts from uninjured WT mice treated for 7 d with WFA (2 mg/kg/d) or vehicle (DMSO). Total protein extracts were fractionated by SDS-PAGE and blots were probed with anti-vimentin, and anti-pERK1/2 antibodies. β-actin antibody was used as loading control.&lt;/p&gt;
Total Asymmetric Synthesis of the Potent Immunosuppressive Marine Natural Product Microcolin A (1996)

The total asymmetric synthesis of the potent immunosuppressive compound microcolin A is reported. The synthesis establishes the absolute stereochemistry of microcolin A as C-36R, C-38R, and C-4S on the basis of the diastereoselective preparation of all four possible diastereomers of the lipid region (fragment A) and diastereoselective synthesis of fragment C starting from natural l-(S)-alanine. The strategy involves a convergent assemblage of three optically pure fragments and is amenable to chemical modifications to examine structural analogs for biological study.
Local Network Properties of Soil and Rhizosphere Microbial Communities in Potato Plantations Treated with a Biological Product Are Important Predictors of Crop Yield (2021)

Our results reinforce the notion that each cultivar on each location recruits a unique microbial community and that these communities are modulated by the vegetative growth stage of the plant. Moreover, inoculation of a Bacillus amyloliquefaciens strain QST713-based product on potatoes also changed the abundance of specific taxonomic groups and the structure of local networks in those locations where the product caused an increase in the yield.
A Practical Guide to the Combinatorial Clock Auction (2017)

Since its proposal in a 2006 academic paper, the combinatorial clock auction (CCA) has rapidly established itself as one of the leading formats for government auctions of telecommunications spectrum. Its initial implementations were for relatively small auctions and some of these applications may be viewed as experimental. However, in the past few years, usage of the CCA has gained substantial momentum. From 2012 to this writing in 2015, the CCA has been used for more than ten major spectrum auctions worldwide, allocating prime sub-1-GHz spectrum on three continents and raising approximately $20 billion in revenues (see Table 1). Despite the presence of an existing auction format—the simultaneous multiple round auction (SMRA)—which often performs reasonably well, the CCA has the potential of displacing it and becoming the new standard design choice for spectrum auctions.
Towards a Hybrid Human-Computer Scientific Information Extraction Pipeline (2017)

The emerging field of materials informatics has the potential to greatly reduce time-to-market and development costs for new materials. The success of such efforts hinges on access to large, high-quality databases of material properties. However, many such data are only to be found encoded in text within esoteric scientific articles, a situation that makes automated extraction difficult and manual extraction time-consuming and error-prone. To address this challenge, we present a hybrid Information Extraction (IE) pipeline to improve the machine-human partnership with respect to extraction quality and person-hours, through a combination of rule-based, machine learning, and crowdsourcing approaches. Our goal is to leverage computer and human strengths to alleviate the burden on human curators by automating initial extraction tasks before prioritizing and assigning specialized curation tasks to humans with different levels of training: using non-experts for straightforward tasks such as validation of higher accuracy results (e.g., completing partial facts) and domain experts for low-certainty results (e.g., reviewing specialized compound labels). To validate our approaches, we focus on the task of extracting the glass transition temperature of polymers from published articles. Applying our approaches to 6 090 articles, we have so far extracted 259 refined data values. We project that this number will grow considerably as we tune our methods and process more articles, to exceed that found in standard, expert-curated polymer data handbooks while also being easier to keep up-to-date. The freely available data can be found on our Polymer Properties Predictor and Database website at http://pppdb.uchicago.edu.
Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes (2015)

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.
Porous wall hollow glass microspheres as a medium or substrate for storage and formation of novel materials (2023)

Porous wall hollow glass microspheres are provided as a template for formation of nanostructures such as carbon nanotubes, In addition, the carbon nanotubes in combination with the porous wall hollow glass microsphere provides an additional reaction template with respect to carbon nanotubes.
High Pressure Processing of Foods (2007)

High pressure processing of foods , High pressure processing of foods , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Phenylpropenamide Derivatives AT-61 and AT-130 Inhibit Replication of Wild-Type and Lamivudine-Resistant Strains of Hepatitis B Virus In Vitro (2002)

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 +/- 9.5 and 2.40 +/- 0.92 micro M, respectively, compared to 0.064 +/- 0.020 micro M lamivudine. There were no significant differences in sensitivity between wild-type and nucleoside analogue-resistant (rtL180M, rtM204I, and rtL180M + rtM204V) HBV.
Green Synthesis of Silver Nanoparticles Using Juniperus procera Extract: Their Characterization, and Biological Activity (2022)

Plant extract-based green synthesis of metal nanoparticles (NPs) has become a popular approach in the field of nanotechnology. In this present investigation, silver nanoparticles were prepared by an efficient and facile approach using Juniperus procera extract as a bioreducing and stabilizing agent. The as-synthesized silver nanoparticles (JP-AgNPs) were characterized by several characterization techniques such as UV–Vis, XRD, FT-IR, HR-TEM, and EDX analysis. The XRD analysis evidently confirms that the as-synthesized Ag nanoparticles (NPs) from Juniperus procera plant extract (JP-AgNPs) are crystalline in nature. FT-IR analysis confirms that the plant extract plays a dual role as a bioreducing and capping agent, while HR-TEM revealed the spherical morphology of as-synthesized JP-AgNPs with the size of ~23 nm. Furthermore, the synthesized JP-AgNPs were evaluated for antibacterial properties against several bacterial and fungal strains such as Staphylococcus aureus (ATCC 12228), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Proteus mirabilis (ATCC 4753), Cryptococcus neoformans (ATCC 16620), and Candida albicans (ATCC 885-653). The JP-AgNPs displayed an efficient mean zone of inhibition (MZI) at 50.00 µL for bacterial associated with fungal pathogens than the plant extract. Mainly, MZI values against microbial pathogens were as follows; E. coli (17.17 ± 0.72 mm), P. mirabilis (14.80 ± 0.17 mm), and C. albicans (14.30 ± 0.60 mm), whereas JP-AgNPs showed moderate activity against P. aeruginosa (11.50 ± 0.29 mm) and C. neoformans (9.83 ± 0.44 mm). Notably, the tested JP-AgNPs have displayed almost similar antimicrobial activities with that of standard antimicrobial drugs, such as streptomycin and nystatin. The enhanced antimicrobial activity of JP-AgNPs can be ascribed to the quality of resultant NPs including, uniform size, shape, and aqueous colloidal stability of nanoparticles.
Intoxikation mit einem unbekannten Sedativum = Intoxication with an unknown sedative substance (2008)

We describe a 64-year old patient who was admitted comatose to the medical emergency department. After excluding relevant differential diagnoses and considering the clinical picture of a toxidrome a presumable diagnosis of an intoxication with an unknown sedative substance was made. Phenobarbital was detected in the blood. Decontamination procedures and therapy in patients with phenobarbital intoxication are delineated and discussed.
Serializable eventual consistency (2016)

In order to allow offline functionality of (mobile) web applications, state needs to be optimistically replicated and synchronized whenever connection is re-established. We present a programming language solution that provides replicated application state in a cloud-client setting. It exposes first-class replicated objects to the programmer, which are automatically replicated to all clients and locally accessible. By executing all method invocations in the same order on all sites, as determined by the cloud, consistency is attained. We call this serializable eventual consistency. The model encapsulates tentative operation buffering, reordering and propagation and provides primitives to reason about tentative state.
The pH‐dependent reciprocal changes in contributions of ADP/ATP antiporter and aspartate/glutamate antiporter to the fatty acid‐induced uncoupling (1997)

The pH effect on carboxyatractylate-, glutamate- and aspartate-induced recoupling of palmitate-uncoupled rat liver mitochondria has been studied. Stimulation of respiration by low palmitate concentrations (5-20 microM) in the presence of 3 mM MgCl2 is shown to be pH-independent within the 7.0-7.8 range. The recoupling effect of glutamate (or aspartate) decreases and that of carboxyatractylate increases with increase in pH. The recoupling effect of a combination of carboxyatractylate and glutamate (aspartate) appears to be constant at these pH values, being as high as about 80%. It is concluded that uncoupling by low palmitate in liver mitochondria is mediated mainly by ATP/ADP and aspartate/glutamate antiporter.
pH‐dependent fibrillogenesis of a VκIII Bence Jones protein (1999)

Disorders of immunoglobulin (Ig) synthesis that occur in malignant plasma-cell proliferation may result in either granular (LCDD) or fibrillar (AL) tissue deposition of light-chain monoclonal components. The structural features that govern the transition from soluble polypeptides to either fibrillar or granular conformational states remain undefined. Among the many factors presumed to play a role in these transitions the net charge of the molecule has been associated with folding conformation changes. The majority of the proteins involved in AL amyloidosis show acidic isoelectric points (pI 3.8-5.2), whereas most L chains with basic pIs deposit in granular patterns. In our studies a 12 kD VkappaIII fragment was purified as the main component of the fibrils isolated from myocardium and adipose tissue of the pericardium obtained post-mortem from an individual with systemic AL amyloidosis. An apparently identical 12 kD VL fragment with the same N-terminal sequence constituted the BJ protein present in the urine. This urinary protein exhibited strikingly cathodic electrophoretic mobility on agarose gels and lacked retention by anionic exchange chromatography matrices, indicative of a highly basic pI (>10). When it was subjected to in vitro fibril-formation experiments, the BJ protein adopted a fibrillar conformation only at acidic pHs, remaining aggregated but not fibrillar at physiological pH. The data indicate that a specific tissue deposition pattern involves not only structural properties of the protein but rather more complex mechanisms in which acidic micro-environments may contribute to the stabilization of amyloidogenic conformations.
High power single-polarization fiber lasers (2004)

The design and performance of several novel Yb-doped laser fibers is reviewed. In particular, all-glass double-clad fibers and single-polarization fibers as technologies for developing the next generation of high-power fiber lasers are discussed.