gebhart/patrepeval huggingface dataset:
Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection (2012)

Abstract Background Infection with HIV-1 results in marked immunologic insults and structural damage to the intestinal mucosa, including compromised barrier function. While the development of highly active antiretroviral therapy (HAART) has been a major advancement in the treatment of HIV-1 infection, the need for novel complementary interventions to help restore intestinal structural and functional integrity remains unmet. Known properties of pre-, pro-, and synbiotics suggest that they may be useful tools in achieving this goal. Methods This was a 4-week parallel, placebo-controlled, randomized pilot trial in HIV-infected women on antiretroviral therapy. A synbiotic formulation (Synbiotic 2000®) containing 4 strains of probiotic bacteria (10 10 each) plus 4 nondigestible, fermentable dietary fibers (2.5 g each) was provided each day, versus a fiber-only placebo formulation. The primary outcome was bacterial translocation. Secondary outcomes included the levels of supplemented bacteria in stool, the activation phenotype of peripheral T-cells and monocytes, and plasma levels of C-reactive protein and soluble CD14. Results Microbial translocation, as measured by plasma bacterial 16S ribosomal DNA concentration, was not altered by synbiotic treatment. In contrast, the synbiotic formulation resulted in significantly elevated levels of supplemented probiotic bacterial strains in stool, including L. plantarum and P. pentosaceus, with the colonization of these two species being positively correlated with each other. T-cell activation phenotype of peripheral blood lymphocytes showed modest changes in response to synbiotic exposure, with HLA-DR expression slightly elevated on a minor population of CD4+ T-cells which lack expression of HLA-DR or PD-1. In addition, CD38 expression on CD8+ T-cells was slightly lower in the fiber-only group. Plasma levels of soluble CD14 and C-reactive protein were unaffected by synbiotic treatment in this study. Conclusions Synbiotic treatment for 4 weeks can successfully augment the levels of probiotic species in the gut during chronic HIV-1 infection. Associated changes in microbial translocation appear to be absent, and markers of systemic immune activation appear largely unchanged. These findings may help inform future studies aimed at testing pre- and probiotic approaches to improve gut function and mucosal immunity in chronic HIV-1 infection. Trial registration Clinical Trials.gov: NCT00688311
Optical network control challenges (2009)

This paper discusses two challenges, failure recovery enhancement and scalability enhancement, on optical network control plane. These challenges enable us to provide optical networks with high reliability and lower operational cost.
MoM analysis of patch antenna array using fast algorithm for solving matrix equation (2004)

An iterative algorithm based on the Gauss-Seidel method has been proposed to solve the matrix equation of the MoM analysis for the array antenna. The numerical examples show that the CPU time has been greatly reduced compared with a direct method, i.e. the Gauss-Jordan method. The novel iterative algorithm is expected to enable the MoM analysis to be applied to large-scale array antennas, and is applied to solve a patch antenna array to show the validity of the method.
Next-gen batteries: Enabled by spatial atomic layer interfacing (2020)

Li-ion batteries have emerged as the key energy storage technology, not only in portable electronics &amp; gadgets but also in electric vehicles (EV) and grid-storage. A combination of high energy density anodes such as silicon or lithium, and Ni- or Li-rich cathode1,2 is necessary to achieve the targeted energy density of &gt;350 Wh/Kg. The challenge is that such extreme redox-chemistries bring safety issues and degradation3, especially at the electrode-electrolyte interfaces4. In order to improve safety, solid polymer electrolytes5 and ceramic electrolytes6 are proposed to replace liquid electrolyte composed of organic solvents, which are highly flammable and toxic. However, most of the solid electrolytes and also the conventional liquid electrolyte (to a lesser extent), has either oxidative or reductive instability against the new generation electrodes leading to capacity degradation during cycling. In brief, most of the safety and capacity degradation issues arise from the incompatibility of electrodes and electrolytes, i.e. highly unstable interfaces. Thus, an optimized interface is the key to the success of new generation Li-ion battery in terms of stability and safety. The preffered way to achieve this is by creating artificial electrode-electrolyte interfaces that are stable against the electrochemical environment and has the ability to protect the electrode as well as electrolyte surfaces from degradation by acting as a lithium conducting barrier. These interfaces can be formed either in-situ using electrolyte additives or ex-situ via chemical or physical methods. However, in the state-of-the-art cells, the above methods have not yet been shown to guaranty the required uniform atomic layer interfacial coating at an industrial scale. The relative newcomer in this field is atomic layer deposition (ALD), has the potential to play a big role in interfacial-engineering owing to its ability to achieve conformal interfacial coatings at an atomic scale7. However, conventional vacuum-based ALD is not compatible with the high throughput roll-to-roll battery electrode production. Here, spatial ALD (sALD)8 technology, an advanced version of ALD at ambient pressure, is a prime choice due to its reel-to-reel scalability and higher throughput. TNO-Holst center has established roll-to-roll sALD in the past several years for various applications. Wide range of materials including metal, metal oxides, nitrides, sulfides, organic, polymer, and polymers are possible using sALD depending upon the chemistry and reactivity at the electrode surfaces. We will showcase various sALD films Al2O3, TiO2, ZnO, etc., which are specifically tailored to address various issues such as lithium dendrite formation, interface stabilization, cathode degradation protection, etc. Thanks to the selective deposition reaction of sALD, the passivation coatings at interfaces can reach all the way down within a thick commercial electrode (50-60μm). Furthermore, our pinhole-free sALD-LiPON electrolyte thin films with Li-ion conductivity &gt;10-7 S/cm will be presented.
GulfHub: Leveraging industry-academic partnerships to expand physical oceanographic data availability in the Gulf of Mexico (2020)

The Gulf of Mexico offshore energy industry has collected an immense amount of physical oceanographic data over the last three decades. The Gulf of Mexico Coastal Ocean Observing System Regional Association (GCOOS-RA), in collaboration with Texas A & M University in College Station and Corpus Christi, RPS Group, CLS Woods Hole Group, Fugro, and Ocean Sierra LLC, has gained access to many of these data from individual companies and also from Joint Industry Projects (JIPs). The acquired datasets have been fully quality controlled to U.S. Integrated Ocean Observing System (IOOS) standards and metadata appropriately supplemented. The datasets are available online through the GCOOS GulfHub data portal for us by anyone. In this paper, the overall project, system architecture and disaster recovery plan are described and an introduction to the available datasets, previously privately held, is provided. At the time of writing, more than 4600 unique physical oceanographic datasets are available on the GulfHub ERDDAP server. Of these, more than 2900 were previously industry proprietary datasets from deepwater moorings, offshore oil rigs and platforms, and vessels. It is anticipated that more than 5000 datasets will be available upon completion of the project, including data collected in the Understanding the Gulf Ocean Systems (UGOS) initiative of the National Academies of Sciences, Engineering, and Medicine. The paper includes summaries of the extent and content of the various datasets. The research reported in this paper was supported by the Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine under award number 2000009971.
A missing factor in chip-based patch clamp assay: gigaseal (2006)

The ''gold'' standard in the study of ionic currents across biological membranes is the Patch Clamp method. However, this is a slow, labor and skill intensive process. High throughput patch clamp devices are mainly chip-based. A major challenge in these miniaturized devices is the low rate of ''Gigaseal'' formation which is critical in the study of Single Channel effect. In a conventional patch clamp, a pipette moves and patches a fixed cell (cell-adhered patch) which is grown on the bottom of a Petri dish. In the chip-based case, the cells are in suspension and move towards the fixed patch clamp sites (cell-suspended patch). In this study, using the proven conventional patch clamp setup, we investigated the effect of the differences in the cell configurations between the convention patch clamp and cell-based patch clamp. It is shown that adhered cells (as used in the conventional setup) have a much higher rate of gigaseal formation as compared to the cells in suspension (as used in chip-based devices). We postulate that the arrangement of the cytoskeleton within the cell plays a major part in the formation of the gigaseal.
58‐2: Revealing the Excited‐state Dynamics of Thermally Activated Delayed Flourescence Molecules by using Transient Absorption Spectrospy (2016)

Excited state dynamics is a central issue in discussing the origin of the high efficiency of thermally activated delayed fluorescence (TADF) molecules. Here we will present experimentally a complexity of the excited state dynamics of the extremely high efficient TADF molecules, 4CzIPN. By means of pump‐probe transient absorption spectroscopy, we will show the sign of intramolecular charge delocalization formed in the excited state. This specific excited state originates from the intramolecular charge resonance within carbazole moieties, which occurs through the dimerization of the moieties. On the other hand, the counter molecules of 4CzIPN, i.e. 2CzPN, forms only a localized excited state. The role of charge delocalized state for TADF efficiency will be discussed.
A Multiple Camera 5G Wireless Studio for Professional Content Production Scenarios (2022)

In this paper, a detailed overview of the H2020 European 5G-RECORDS project Use Case 2 (UC2) is presented. Currently, the project is in its 20 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> month of 26 and it is in the final stages of integration, tests and trials. The project devised three use cases focused around exploring 5G technologies for content production scenarios. Use Case 2 is “Multiple Camera Wireless Studio” and has two main objectives: exploring how 5G can help create an IP studio environment in which wired and wireless equipment can be used for media content production; and how 5G can help for remote contribution scenarios. The paper outlines the envisioned scenarios, describes the components of the use case (a detailed description of two of the components is given: the Media Gateway and the Media Orchestration and Control Gateway), the results obtained via a series of tests performed to demonstrate the validity of multiple production scenarios are presented and finally work remaining, expected outcomes and future beyond the project are discussed.
Dramatic Influence of Nitrogen Heterocycles on the Activity of Low-Valent Titanium Reagent: An Improved One-Pot Synthesis of Phenanthrenes (1995)

Abstract A novel low-valent titanium (LVT) induced one-pot synthesis of phenanthrenes (25–38% yield) from ortho-alkoxy aromatic aldehydes/ketones was reported by us earlier. Activity of LVT complex could be modulated rationally by using catalytic amount of pyridine. Use of this LVT-pyridine reagent system improved the yields of phenanthrenes (3) by two folds.
Production and Purification of Dengue Virus-like Particles from COS-1 Cells (2019)

Non-infectious virus-like particles (VLPs) containing dengue virus (DENV) pre-membrane (prM) and envelope (E) proteins have been demonstrated to be highly immunogenic and can be used as a potential vaccine candidate as well as a tool for serodiagnostic assays. Successful application of VLPs requires abundant, and high-purity production methods. Here, we describe a robust protocol for producing DENV VLPs from transiently-transformed or stable COS-1 cells and further provide an easily adaptable antigen purification method by sucrose gradient centrifugation.
Computer-assisted Treatment Of Brain Lesions With The Aid Of 3-13 Images (2005)

A frameless stereotaxic device can make retrospective use of medical images in order to guide treatment of brain lesions. For example, computer-simulated incision contous, drawn on 3-D brain images derived from MRI data, can be eansfened lxeoperatively to the patient’s head. Radiotherapy play. drawn on CT images. can be used to steer radiation beams over a pabent. The.se applications will be illustrated with experimental data from phantoms, volunteers. and patients.
Development of a Reversed-Phase High-Performance Liquid Chromatographic Method for Analyzing Furanocoumarin Components in Citrus Fruit Juices and Chinese Herbal Medicines (2009)

A rapid and sensitive reversed-phase high performance liquid chromatographic method for the quantitation of five furanocoumarins (bergaptol, psoralen, bergapten, 6',7'-dihydroxybergamottin, and bergamottin) is developed and validated. HPLC analysis of these five furanocoumarins is performed on a reversed-phase Inertsil ODS-2 column with a particle size of 5 microm. Using only water and acetonitrile as solvents, good separation, good precision, and high accuracy are obtained for the analysis of furanocoumarin components. This method is validated and applied to analyze the composition of five furanocoumarins in four citrus fruit juices (grapefruit, pomelo I, pomelo II, and shaddock) and ten Chinese herbal medicines (Bai-Zhi, Qiang-Huo, Du-Huo, Fang-Feng, Dang-Gui, Huang-Qin, Gan-Cao, Chen-Pi, Ge-Gen, and Yin-Chen-Hao) prepared by water decoction or an alcohol infusion. Results show that four of the five furanocoumarins (but not bergapten) are detected in grapefruit, pomelo I, and pomelo II, and the highest amount of these components is found in grapefruit juice. In the ten Chinese herbal medicines, the five furanocoumarins are not detected in Ge-Gen or Yin-Chen-Hao. The remaining herbs contain various compositions and amounts of furanocoumarins. In general, Chinese herbal medicines prepared by the 40% ethanol infusion contain larger amounts of furanocoumarins than those prepared by hot water decoction.
Quasi-conformal transformation optics techniques for graphene-based integrated photonic components (2014)

We present the use of quasi-conformal transformation optics techniques to design integrated photonic components on graphene sheets. First, we discuss the required design equations necessary for associating the permittivity tensors achieved from transformation optics techniques to the electronic transport properties of graphene. We then present the design of several novel integrated photonic components using the proposed process, including a quad-beam collimator, waveguide coupler, and waveguide crosser. The theoretical operation of each device will be presented and possible fabrication considerations will be discussed.
Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm (2016)

clinicaltrials.gov Identifier: NCT00094575.
Moving Towards Mmwave-Based Beyond-4G (B-4G) Technology (2013)

Availability of large untapped spectrum resources in the millimeter wave (Mmwave) band is suitable for providing a gigabit experience with true local feel using high capacity small cells. Unlike traditional cellular systems, millimeter wave transmissions do not benefit from diffraction and dispersion making it difficult for them to propagate around obstacles thus resulting in higher shadowing loss. They also have less favorable link budgets due to lower power amplifier (PA) output powers and greater pathloss at these higher frequencies. Also, current costs of the Mmwave circuits are higher, but the costs will become much lower when the technology becomes mainstream. One advantage of millimeter wave, however, is that the smaller wavelengths allow for the fabrication of antenna arrays having a much higher number of antenna elements in a much smaller area than is typical at microwave bands. In this article, we outline a framework for Beyond-4G (B-4G) local area network in the millimeter wave band for both access and backhaul including air-interface, antenna-arrays and IC technology. It is shown that Mmwave B-4G small cell technology can provide peak and cell edge rates greater than 10 Gbps and 100 Mbps respectively with latency less than 1msec for local area network.
Influence of the dislocation density on hardening precipitation in Inconel© 625 (2017)

International audience
Radioimmunotherapy in non-Hodgkin's lymphoma (NHL) using a fractionated schedule of DOTA-conjugated, 90Y-radiolabeled, humanized anti-CD22 monoclonal antibody, epratuzumab (2004)

2545 Background: A phase I/II, multi-center, dose-escalation trial was conducted to establish the safety, optimal dosing, and preliminary efficacy of 90Y-epratuzumab administered weekly for 2 or 3 consecutive wks to pts with B-cell NHL who failed ≥1 regimen of standard chemotherapy. Methods: Eligibility criteria included <25% BM involvement, plts >100,000 cells/mm3, and measurable disease by CT with no single mass >10 cm. Pts received 1.5 mg/kg/wk epratuzumab with 111In-epratuzumab co-administered the 1st wk. Twenty-six pts with a median of 3 prior treatments have been treated, including 15 pts without prior bone marrow transplant (BMT) at 5–10 mCi/m2/wk (total 90Y dose, 15–22.5 mCi/m2) and11 pts with prior BMT escalated separately at 2.5–5 mCi/m2/wk (total 90Y dose, 5–10 mCi/m2). Results: Dose escalation is continuing, with no serious AEs considered treatment-related. One pt in each escalation arm had protocol-defined DLT (>12 wk platelet recovery); otherwise, therapy was well tolerated with no significant toxicity besides transient hematologic depression, including 4 pts retreated without additional toxicity. 111In imaging demonstrated antibody tumor targeting, and hot/cold PK demonstrated stability of DOTA chelation ≥1 wk. In 22 pts with treatment evaluations, 13 pts (59%) had an objective response (OR) by IWG criteria, including pts with and without BMT [5/9 (56%) and 8/13 (62%), respectively], with indolent and aggressive disease [8/10 (80%) and 5/12 (42%), respectively], across histologies [follicular NHL, 9/12 (75%); DLCL, 2/4 (50%); mantle cell, 2/6 (33%)], and in pts failing rituximab (9/15, 60%). Most OR's were complete responses (CR/CRu, 9/13, 69%), and 3/5 pts assessed after CR onset now have responses >6 mo, including 2 pts continuing >1 yr. Conclusion: This study shows the feasibility and safety of a dose-fractionation schedule of a 90Y-labeled anti-CD22 Mab, obtaining therapeutic responses across all pt groups, including durable complete responses, and achieving higher cumulative doses than other RAIT agents given as single doses. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Immunomedics Immunomedics Immunomedics Immunomedics
Laser-Assisted Photoelectric Effect on Pt(111) (2006)

We observe the laser-assisted photoelectric effect on a surface for the first time. Simultaneously illuminating Pt( 111) with the fundamental and 27th harmonic of a Ti:sapphire femtosecond laser results in energy modulation of the photoelectron spectrum.
Theoretical analysis of coma aberration measurement for aerial image sidelobe peaks (2014)

By analyzing aerial images, we characterize the lowest order coma aberration measurements for the projection optics of a microlithography exposure apparatus based on scalar diffraction theory. Our developed method for measuring the coma aberration exploits the intensity difference between the sidelobe peaks appearing near the boundaries of the bright field ("negative") single-line or plural-line patterns. Our method further demonstrates linearity between the intensity difference of the sidelobe peaks and the amount of residual lowest order coma aberration. We analyze the coma aberration sensitivity formula and determine the duty ratio of the line-and-space pattern that realizes the highest aberration sensitivity.
(Trimethylstannyl)vinyl Cuprates:  Generation and Conjugate Addition Reactions (1996)

A new convenient route to the bis[(trimethylstannyl)vinyl] cuprate reagent 9 is described. Its addition to α,β-unsaturated ketones has been studied. Bis(trimethylsilyl)acetamide (BSA) was found to activate 1,4-conjugate addition of 9 to α,β-unsaturated ketone esters without concomitant reduction of the double bond.
Preparation of gas phase naked silver cluster cations outside a mass spectrometer from ligand protected clusters in solution (2018)

Gas phase clusters of noble metals prepared by laser desorption from the bulk have been investigated extensively in a vacuum using mass spectrometry. However, such clusters have not been known to exist under ambient conditions to date. In our previous work, we have shown that in-source fragmentation of ligands can be achieved starting from hydride and phosphine co-protected silver clusters leading to naked silver clusters inside a mass spectrometer. In a recent series of experiments, we have found that systematic desorption of ligands of the monolayer protected atomically precise silver cluster can also occur in the atmospheric gas phase. Here, we present the results, wherein the [Ag18H16(TPP)10]2+ (TPP = triphenylphosphine) cluster results in the formation of the naked cluster, Ag17+ along with Ag18H+ without mass selection, outside the mass spectrometer, in air. These cationic naked metal clusters are prepared by passing electrosprayed ligand protected clusters through a heated tube, in the gas phase. Reactions with oxygen suggest Ag17+ to be more reactive than Ag18H+, in agreement with their electronic structures. The more common thiolate protected clusters produce fragments of metal thiolates under identical processing conditions and no naked clusters were observed.
Synthesis, Stability, and Photochemistry of Pentacene, Hexacene, and Heptacene: A Matrix Isolation Study (2009)

The photochemical bisdecarbonylation of bridged alpha-diketones (Strating-Zwanenburg reaction) to give the oligoacenes pentacene (2), hexacene (3), and heptacene (4) is investigated in solid inert gas matrices at cryogenic temperatures. The photodecomposition using visible light irradiation cleanly produces the corresponding oligoacene without formation of observable intermediates. This synthetic approach to the higher acenes allows a comprehensive comparative study of their electronic absorption and infrared spectral properties under identical conditions for the first time. In addition, the route makes it possible to investigate the thermal and photochemical stability of these higher acenes and addresses the problem of heptacene stability which dates back almost 70 years. This largest known member of the acene series is found to be unstable at room temperature. Furthermore, all oligoacenes 2-4 undergo a photoredox reaction upon 185 nm excitation, resulting in the concurrent formation of radical cations and anions in the noble gas matrix. These polaron states of the oligoacenes are stable under the conditions of their generation but collapse to the uncharged acenes upon visible light irradiation.
Fibrate Use in the United States and Canada (2011)

To the Editor: Dr Jackevicius and colleagues reported an interesting trend of increasing fenofibrate prescriptions in the United States in the face of data questioning its value in reducing cardiovascular events in patients with diabetes.1