gebhart/patrepeval huggingface dataset:
Model based multi-pass macroblock-level rate control for visually improved video coding (2002)

Visual quality of video depends not only on global measures (like average PSNR over a sequence) but also on how the error is distributed in space and time. Typical macroblock layer rate control schemes adapt the quantization parameters (QP) over a frame to meet the frame level bit target. However, large variations of QP over a coherent spatio-temporal region results in visually displeasing artifacts. Thus, it is important to maintain smoothly varying QP for each visually significant region. In this paper we present a multipass scheme that achieves such a QP adaptation that is also commensurate with the visual significance of each region in the scene. Such a true multipass scheme is then approximated by a rate-distortion (R-D) model-based pseudo-multipass scheme that is suitable for real-time implementation.
Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome (2016)

The mechanism responsible for the altered spectrum of tear proteins secreted by lacrimal gland acinar cells (LGAC) in patients with Sjögren's Syndrome (SS) remains unknown. We have previously identified increased cathepsin S (CTSS) activity as a unique characteristic of tears of patients with SS. Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC. Similar to patients with SS and to the male nonobese diabetic (NOD) mouse model of SS, CTSS activity was elevated in tears of mice lacking Rab3D. Findings of lower gene expression and altered localization of Rab3D in NOD LGAC reinforce a role for Rab3D in suppressing excess CTSS release under physiological conditions. However, CTSS activity was significantly reduced in tears of mice lacking Rab27 isoforms. The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC. High-resolution 3D-structured illumination microscopy revealed microdomains of Rab3D and Rab27 isoforms on the same secretory vesicles but present in different proportions on different vesicles, suggesting that changes in their relative association with secretory vesicles may tailor the vesicle contents. We propose that a loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of CTSS in tears of patients with SS.
ChemInform Abstract: Preparation and Isolation of Polyenes Containing up to 15 Double Bonds. (1988)

Abstract Ring‐opening oligomerization of the tricyclodecatriene (I) to give the adducts (V) as an oligomeric mixture is achieved via the metal complexes (III).
Modulation of arachidonic acid metabolism by curcumin and related -diketone derivatives: effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase (2004)

Aberrant arachidonic acid metabolism is involved in the inflammatory and carcinogenic processes. In this study, we investigated the effects of curcumin, a naturally occurring chemopreventive agent, and related beta-diketone derivatives on the release of arachidonic acid and its metabolites in the murine macrophage RAW264.7 cells and in HT-29 human colon cancer cells. We also examined their effects on the catalytic activities and protein levels of related enzymes: cytosolic phospholipase A(2) (cPLA(2)), cyclooxygenases (COX) as well as 5-lipoxygenase (5-LOX). At 10 micro M, dibenzoylmethane (DBM), trimethoxydibenzoylmethane (TDM), tetrahydrocurcumin (THC) and curcumin effectively inhibited the release of arachidonic acid and its metabolites in lipopolysaccharide (LPS)-stimulated RAW cells and A23187-stimulated HT-29 cells. Inhibition of phosphorylation of cPLA(2), the activation process of this enzyme, rather than direct inhibition of cPLA(2) activity appears to be involved in the effect of curcumin. All the curcuminoids (10 micro M) potently inhibited the formation of prostaglandin E(2) (PGE(2)) in LPS-stimulated RAW cells. Curcumin (20 micro M) significantly inhibited LPS-induced COX-2 expression; this effect, rather than the catalytic inhibition of COX, may contribute to the decreased PGE(2) formation. Without LPS-stimulation, however, curcumin increased the COX-2 level in the macrophage cells. Studies with isolated ovine COX-1 and COX-2 enzymes showed that the curcuminoids had significantly higher inhibitory effects on the peroxidase activity of COX-1 than that of COX-2. Curcumin and THC potently inhibited the activity of human recombinant 5-LOX, showing estimated IC(50) values of 0.7 and 3 micro M, respectively. The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX. These activities may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs.
Effect of nitrogen incorporation into Al-based gate insulators in AlON/AlGaN/GaN metal–oxide–semiconductor structures (2016)

Abstract The superior physical and electrical properties of aluminum oxynitride (AlON) gate dielectrics on AlGaN/GaN substrates in terms of thermal stability, reliability, and interface quality were demonstrated by direct AlON deposition and subsequent annealing. Nitrogen incorporation into alumina was proven to be beneficial both for suppressing intermixing at the insulator/AlGaN interface and reducing the number of electrical defects in Al 2 O 3 films. Consequently, we achieved high-quality AlON/AlGaN/GaN metal–oxide–semiconductor capacitors with improved stability against charge injection and a reduced interface state density as low as 1.2 × 10 11 cm −2 eV −1 . The impact of nitrogen incorporation into the insulator will be discussed on the basis of experimental findings.
Spiking neurons from tunable Gaussian heterojunction transistors (2020)

Spiking neural networks exploit spatiotemporal processing, spiking sparsity, and high interneuron bandwidth to maximize the energy efficiency of neuromorphic computing. While conventional silicon-based technology can be used in this context, the resulting neuron-synapse circuits require multiple transistors and complicated layouts that limit integration density. Here, we demonstrate unprecedented electrostatic control of dual-gated Gaussian heterojunction transistors for simplified spiking neuron implementation. These devices employ wafer-scale mixed-dimensional van der Waals heterojunctions consisting of chemical vapor deposited monolayer molybdenum disulfide and solution-processed semiconducting single-walled carbon nanotubes to emulate the spike-generating ion channels in biological neurons. Circuits based on these dual-gated Gaussian devices enable a variety of biological spiking responses including phasic spiking, delayed spiking, and tonic bursting. In addition to neuromorphic computing, the tunable Gaussian response has significant implications for a range of other applications including telecommunications, computer vision, and natural language processing.
Multicomponent Phase Separation in Ternary Mixture Ionic Liquid Electrolytes (2021)

We investigate the phase behavior of ternary mixtures of ionic liquid, organic solvent, and lithium salt by molecular dynamics simulations. We find that at room temperature, the electrolyte separates into distinct phases with specific compositions; an ion-rich domain that contains a fraction of solvent molecules and a second domain of pure solvent. The phase separation is shown to be entropy-driven and is independent of lithium salt concentration. Phase separation is only observed at microsecond time scales and greatly affects the transport properties of the electrolyte.
HOW COMMON IS LATE RECURRENCE AFTER RADICAL PROSTATECTOMY? (2008)

You have accessJournal of Urology1 Apr 2008HOW COMMON IS LATE RECURRENCE AFTER RADICAL PROSTATECTOMY? Shilajit D Kundu, Angel M Cronin, Fernando J Bianco, Peter T Scardino, James A Eastham, and Andrew J Vickers Shilajit D KunduShilajit D Kundu More articles by this author , Angel M CroninAngel M Cronin More articles by this author , Fernando J BiancoFernando J Bianco More articles by this author , Peter T ScardinoPeter T Scardino More articles by this author , James A EasthamJames A Eastham More articles by this author , and Andrew J VickersAndrew J Vickers More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60592-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "HOW COMMON IS LATE RECURRENCE AFTER RADICAL PROSTATECTOMY?." The Journal of Urology, 179(4S), pp. 204–205 © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byCritz F, Benton J, Shrake P and Merlin M (2018) 25-Year Disease-Free Survival Rate After Irradiation for Prostate Cancer Calculated with the Prostate Specific Antigen Definition of Recurrence Used for Radical ProstatectomyJournal of Urology, VOL. 189, NO. 3, (878-883), Online publication date: 1-Mar-2013. Volume 179Issue 4SApril 2008Page: 204-205 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Shilajit D Kundu More articles by this author Angel M Cronin More articles by this author Fernando J Bianco More articles by this author Peter T Scardino More articles by this author James A Eastham More articles by this author Andrew J Vickers More articles by this author Expand All Advertisement PDF downloadLoading ...
Mechanism of one-electron electrochemical reductive cleavage reactions of sulfonium salts (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of one-electron electrochemical reductive cleavage reactions of sulfonium saltsFranklin D. Saeva and Bradley P. MorganCite this: J. Am. Chem. Soc. 1984, 106, 15, 4121–4125Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ja00327a010https://doi.org/10.1021/ja00327a010research-articleACS PublicationsRequest reuse permissionsArticle Views1003Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design And Characterization Of Polarization-Maintaining Fiber Splices And Connectors (1987)

Polarization-maintaining fibers preserve a stable state of polarization over long propagation lengths and are ideal candidates for applications such as coherent communication, fiber devices and interconnection of guided wave devices. Connection technology for polarization-maintaining fibers is reviewed, design difficulties are examined, characterization techniques for these splices and connectors are analyzed. Reported results on individual polarization-maintaining fiber splices and connectors are described. In addition, linear arrays of polarization-maintaining fibers suitable for guided wave applications are reviewed. It is concluded that splices and connectors for polarization-maintaining fibers are being studied by many investigators; however, most of these techniques require active alignment of the polarization axes. Passive alignment appears feasible if a suitably accurate, external polarization-axis reference is designed into the fiber.
Angled broad-area semiconductor lasers to emit high output power with good beam quality (2004)

A new type of laser diodes with good beam quality is introduced. The far-field divergence angle can be close to diffraction-limited value. In the new design, the direction of the waveguide on a broad area Fabry-Perot laser diode is tilted at an angle from the facet normal. This design is called “angled broad area laser diode”. In this tilted waveguide device, filamentation is not observed. The far-field divergence angle is generally within 5 times the diffraction-limited value. This tilted broad area laser is advantageous over the angled grating DFB laser because the difficulty of matching the grating period with peak gain wavelength is avoided.
Imaging Monoamine Transporters in the Brain (2002)

In vivo imaging of receptors and binding sites in the brain using PET (positron emission tomography) or SPECT (single photon emission computed tomography) provides functional information of central nervous system (CNS) in normal or disease states. Imaging agents for dopamine transporters (DAT), such as [11C]-CFT, [123I]-β-CIT, [123I]-FP-β-CIT, [123I]-IPT, [123I]-altropane and [99mTc]TRODAT-1, are useful in evaluating changes in presynaptic DAT sites in vivo in patients with Parkinson's disease (PD). Serotonin transporters (SERT) play an important role in modulating the serotonergic neuronal function. Selective tracers of SERT, such as [11C](+)McN5652, [123I]IDAM, [11C]DASB and [123I]ADAM, are important to study the specific binding sites non-invasively in the human brain by SPECT and PET imaging.
A toolbox of immunoprecipitation-grade monoclonal antibodies against human transcription factors (2017)

Abstract A key component to overcoming the reproducibility crisis in biomedical research is the development of readily available, rigorously validated and renewable protein affinity reagents. As part of the NIH Protein Capture Reagents Program (PCRP), we have generated a collection of 1406 highly validated, immunoprecipitation (IP) and/or immunoblotting (IB) grade, mouse monoclonal antibodies (mAbs) to 736 human transcription factors. We used HuProt™ human protein microarrays to identify mAbs that recognize their cognate targets with exceptional specificity. Using an integrated production and validation pipeline, we validated these mAbs in multiple experimental applications, and have distributed them to the Developmental Studies Hybridoma Bank (DSHB) and several commercial suppliers. This study allowed us to perform a meta-analysis that identified critical variables that contribute to the generation of high quality mAbs. We find that using full-length antigens for immunization, in combination with HuProt™ analysis, provides the highest overall success rates. The efficiencies built into this pipeline ensure substantial cost savings compared to current standard practices.
Interim Analysis of the OBOE (Ocrelizumab Biomarker Outcome Evaluation) Study in Multiple Sclerosis (MS) (S24.002) (2018)

To provide interim analysis of the ocrelizumab cerebrospinal fluid (CSF) and blood biomarker study (OBOE, NCT02688985) in multiple sclerosis (MS).
Agelastatin a, a new skeleton cytotoxic alkaloid of the oroidin family. Isolation from the axinellid sponge Agelas dendromorpha of the coral sea (1993)

Agelastatin A, isolated from the axinellid sponge Agelas dendromorpha of the Coral Sea, is a new-skeleton alkaloid with, unusually for the oroidin family to which it belongs, marked cytotoxicity toward tumour cells in culture.
Coupling matrix of a 10th‐order dual‐mode asymmetric canonical filter (2003)

Abstract This paper deals with a simple method to extract the coupling matrix of a 10 th ‐order dual‐mode asymmetric canonical filter. The coupling matrix of an asymmetric canonical filter is obtained by applying a plane rotation technique to the coupling matrix of a symmetric canonical filter. This paper gives a list of pivots and rotation angles to obtain the coupling matrix of an asymmetric canonical‐structure filter. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 38: 64–68, 2003
Defect mitigation and root cause studies in 14 nm half-pitch chemo-epitaxy directed self-assembly LiNe flow (2015)

High-defect density in thermodynamics driven directed self-assembly (DSA) flows has been a major cause of concern for a while and several questions have been raised about the relevance of DSA in high-volume manufacturing. The major questions raised in this regard are: (1) What is the intrinsic level of DSA-induced defects? (2) Can we isolate the DSA-induced defects from the other processes-induced defects? (3) How much do the DSA materials contribute to the final defectivity and can this be controlled? (4) How can we understand the root causes of the DSA-induced defects and their kinetics of annihilation? (5) Can we have block copolymer anneal durations that are compatible with standard CMOS fabrication techniques (in the range of minutes) with low-defect levels? We address these important questions and identify the issues and the level of control needed to achieve a stable DSA defect performance.
Computer-Aided Design of Analog Integrated Circuits and Systems (2002)

The tools and techniques you need to break the analog design bottleneck! Ten years ago, analog seemed to be a dead-end technology. Today, System-on-Chip (SoC) designs are increasingly mixed-signal designs. With the advent of application-specific integrated circuits (ASIC) technologies that can integrate both analog and digital functions on a single chip, analog has become more crucial than ever to the design process. Today, designers are moving beyond hand-crafted, one-transistor-at-a-time methods. They are using new circuit and physical synthesis tools to design practical analog circuits; new modeling and analysis tools to allow rapid exploration of system level alternatives; and new simulation tools to provide accurate answers for analog circuit behaviors and interactions that were considered impossible to handle only a few years ago. To give circuit designers and CAD professionals a better understanding of the history and the current state of the art in the field, this volume collects in one place the essential set of analog CAD papers that form the foundation of today's new analog design automation tools. Areas covered are: . Analog synthesis. Symbolic analysis. Analog layout. Analog modeling and analysis. Specialized analog simulation. Circuit centering and yield optimization. Circuit testing Computer-Aided Design of Analog Integrated Circuits and Systems is the cutting-edge reference that will be an invaluable resource for every semiconductor circuit designer and CAD professional who hopes to break the analog design bottleneck
Melanin-based flexible supercapacitors (2016)

Biocompatible and biodegradable materials that store electrochemical energy are attractive candidates for applications in bioelectronics and electronics for everywhere. We report on the discovery of the energy storage properties of the pigment melanin in supercapacitors and flexible micro-supercapacitors.
Improving the Serum D-Xylose Test for the Identification of Patients With Small Intestinal Malabsorption (2001)

Thus, the addition of a 3-hour D-xylose serum level of less than 22.5 mg/dL to conventional 1-hour D-xylose determination greatly improves the D-xylose test for malabsorption screening.
[Measurement of spontaneous blinks with a high-speed blink analyzing system]. (2008)

This new, non-invasive system is an easy to use measuring method for blink kinematics and is highly reliable and very useful.
Dry Pet Food Flavor Enhancers and Their Impact on Palatability: A Review (2021)

Pet foods are a vital component of the global food industry. Pet food's success depends on its acceptance by both consumers (the pets) and purchasers (the pet owners). Palatability tests using panels of both trained and untrained pets are often used to measure the preference and acceptability of pet foods. Human perception of pet foods is usually determined by descriptive sensory analysis. Since dry pet foods (also known as kibbles), while being the most popular, are the least palatable, palatants as a flavor enhancer are generally added to dry pet foods to increase their acceptability to pets. Pet foods can also be prepared to be more appealing to pet owners if the chosen aromas and flavors are commonly associated with human food. With increasing demand, developing flavor enhancers to meet the needs of both pets and owners is becoming increasingly important. This review summarized the current state of flavor enhancers used in the pet food industry and their influence on food palatability from both animal and human standpoints.
Highly Crystalline Cubic Mesoporous TiO2 with 10-nm Pore Diameter Made with a New Block Copolymer Template (2004)

A strategy is shown to fabricate highly organized mesoporous anatase films exhibiting favorable properties for photocatalysis and photovoltaic applications by the hydrolysis/condensation of TiCl4 in the presence of PHB−PEO block copolymer templates. Dipcoating for evaporation-induced-self-assembly followed by a straight thermal treatment was employed. The evaporation/structuration process and the thermal treatment were mechanistically followed by in situ GISAXS/WAXS measurements, and the final product was carefully analyzed by spectroscopic ellipsometry and transmission electron microscopy to reveal the consequences of crystallization onto the micro-, the meso-, and the macroscale.
Genome and Transcriptome Analysis of the Basidiomycetous Yeast Pseudozyma antarctica Producing Extracellular Glycolipids, Mannosylerythritol Lipids (2014)

Pseudozyma antarctica is a non-pathogenic phyllosphere yeast known as an excellent producer of mannosylerythritol lipids (MELs), multi-functional extracellular glycolipids, from vegetable oils. To clarify the genetic characteristics of P. antarctica, we analyzed the 18 Mb genome of P. antarctica T-34. On the basis of KOG analysis, the number of genes (219 genes) categorized into lipid transport and metabolism classification in P. antarctica was one and a half times larger than that of yeast Saccharomyces cerevisiae (140 genes). The gene encoding an ATP/citrate lyase (ACL) related to acetyl-CoA synthesis conserved in oleaginous strains was found in P. antarctica genome: the single ACL gene possesses the four domains identical to that of the human gene, whereas the other oleaginous ascomycetous species have the two genes covering the four domains. P. antarctica genome exhibited a remarkable degree of synteny to U. maydis genome, however, the comparison of the gene expression profiles under the culture on the two carbon sources, glucose and soybean oil, by the DNA microarray method revealed that transcriptomes between the two species were significantly different. In P. antarctica, expression of the gene sets relating fatty acid metabolism were markedly up-regulated under the oily conditions compared with glucose. Additionally, MEL biosynthesis cluster of P. antarctica was highly expressed regardless of the carbon source as compared to U. maydis. These results strongly indicate that P. antarctica has an oleaginous nature which is relevant to its non-pathogenic and MEL-overproducing characteristics. The analysis and dataset contribute to stimulate the development of improved strains with customized properties for high yield production of functional bio-based materials.
Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk? (2010)

This study demonstrates that RA patients have dilated retinal venular calibre, reflecting systemic inflammation and possibly increased cardiovascular risk. Longitudinal studies correlating retinal vascular calibre with subsequent cardiovascular events will clarify the clinical utility of this test in patients with RA.