gebhart/patrepeval huggingface dataset:
Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled with 47 Sc produced through nat V(p,x) 47 Sc cyclotron irradiation (2020)

<sup>47</sup>Sc is one of the most promising theranostic radionuclides, thanks to its low energy γ-ray emission (159 keV), suitable for single photon emission computed tomography imaging and its intense β <sup>-</sup> emission, useful for tumour treatment. Despite promising preclinical results, the translation of <sup>47</sup>Sc-therapeutic agents to the clinic is hampered by its limited availability. Among different <sup>47</sup>Sc-production routes currently being investigated, the <sup>nat</sup>V(p,x)<sup>47</sup>Sc reaction has proved to be of particular interest, thanks to the low-cost and easy availability on the market of <sup>nat</sup>V material and the diffusion of medium energy proton cyclotrons. However, the cross section of this specific nuclear reaction is quite low and small amounts of Sc-contaminants are co-produced at energies E <sub>P</sub> ≤ 45 MeV, namely <sup>48</sup>Sc and <sup>46</sup>Sc. The main concern with these Sc-contaminants is their contribution to the patient absorbed dose. For such a reason, the absorbed dose contributions to healthy organs and the effective dose contributions by the three radioisotopes, <sup>48</sup>Sc, <sup>47</sup>Sc and <sup>46</sup>Sc, were evaluated using DOTA-folate conjugate (cm10) as an example of radiopharmaceutical product. Considering as acceptable the limits of 99% for the radionuclidic purity and 10% for the contribution of radioactive Sc-contaminants to the total effective dose after <sup>47</sup>Sc-cm10 injection, it was obtained that proton beam energies below 35 MeV must be used to produce <sup>47</sup>Sc through irradiation of a <sup>nat</sup>V target.
Point Containment Queries on Ray-Tracing Cores for AMR Flow Visualization (2022)

Modern graphics processing units come with dedicated hardware to perform ray/triangle intersections and bounding volume hierarchy traversal. While the primary use case for this hardware is photorealistic 3-D computer graphics, with careful algorithm design scientists can also use this special-purpose hardware to accelerate general-purpose computations, such as point containment queries. This article explains the principles behind these techniques and their application to vector field visualization of large simulation data using particle tracing.
Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: Comparison of non-small cell lung cancer and small cell lung cancer (1996)

Clinical protocols for small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) were devised to prospectively select individualized chemotherapy based on in vitro drug sensitivity testing (DST) of cell lines derived from the patient's SCLC tumor cell lines or the patient's fresh NSCLC tumor. DST data derived from SCLC tumor cell lines were available for 33/115 (29%) patients. The DST-selected chemotherapy regimen was administered to 21 (18%) patients, or 64% of patients with DST. In SCLC< the DST-selected chemotherapy was administered either during weeks 13-24 following 12 weeks of etoposide/cisplatin, or at relapse after complete response to etoposide/cisplatin. Several parameters of in vitro drug sensitivity were significantly associated (two-sided P < 0.05) with clinical response to primary therapy and also with response to the DST-selected chemotherapy regimen, but were not associated with survival (P = 0.24). Five patients treated with their DST-selected chemotherapy attained a complete or partial response, compared to 5 of 68 who received an empiric regimen (P = 0.057). A total of 36/165 (22%) NSCLC patients had DST successfully completed. These results directed management for 21/96 (22%) patients who eventually received chemotherapy, or 58% of patients with DST. Response to chemotherapy for the patients treated prospectively with their DST-selected chemotherapy regimen (2/21; 9%) was not significantly different than the response rate for patients treated empirically with etoposide/cisplatin (10/69; 14%) in the absence of in vitro results to direct chemotherapy (P = 0.73). There was no difference in survival by treatment group for the NSCLC patients. The correlation between in vitro and clinical response was not significant for any individual drug or for all drugs considered together, illustrating the poor predictive value of in vitro testing with currently available chemotherapy in NSCLC.
Changes in the invasion level, and impact of alien plants in Finnish semi-natural agricultural habitats (2012)

Using dataset of 508 transects of 50 m2, we assessed changes in the invasion level of alien plant species in semi-natural agricultural habitats in three study years (2001, 2005 and 2010) in four geographical regions of Finland. In addition, the impact of environmental factors on the occurrence of the most common neophytes (alien species introduced after the 17th century) and the impact of neophytes on native species diversity were studied. In total, 37 neophyte species were detected, but neophytes regarded as highly invasive were rare and occasional. We detected spatio-temporal variation in the invasion level, but it changed according to the measure used. For instance, alien species diversity was lower in south-western Finland than in other years in 2005, and the relative alien species richness was highest in southern and lowest in eastern Finland. Preferences for environmental conditions (disturbance, habitat type and geographical location) and the impact on plant diversity varied among the most common neophytes. The most common neophytes were positively rather than negatively associated with native and alien species diversity. The results suggest that alien species management and control methods should be species-specific and considered case-by-case. Neophytes do not yet cause severe problems, but regular monitoring is needed to detect changes in their invasion levels.
Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation (2005)

We evaluated the role of Syk, using an inhibitor, on allergen-induced airway hyperresponsiveness (AHR) and airway inflammation in a system shown to be B cell- and mast cell-independent. Sensitization of BALB/c mice with ovalbumin (OVA) and alum after three consecutive OVA challenges resulted in AHR to inhaled methacholine and airway inflammation. The Syk inhibitor R406 (30 mg/kg, administered orally, twice daily) prevented the development of AHR, increases in eosinophils and lymphocytes and IL-13 levels in bronchoalveolar lavage (BAL) fluid, and goblet cell metaplasia when administered after sensitization and before challenge with OVA. Levels of IL-4, IL-5, and IFN-gamma in BAL fluid and allergen-specific antibody levels in serum were not affected by treatment. Because many of these responses may be influenced by dendritic cell function, we investigated the effect of R406 on bone marrow-derived dendritic cell (BMDC) function. Co-culture of BMDC with immune complexes of OVA and IgG anti-OVA together with OVA-sensitized spleen mononuclear cells resulted in increases in IL-13 production. IL-13 production was inhibited if the BMDCs were pretreated with the Syk inhibitor. Intratracheal transfer of immune complex-pulsed BMDCs (but not nonpulsed BMDCs) to naive mice before airway allergen challenge induced the development of AHR and increases in BAL eosinophils and lymphocytes. All of these responses were inhibited if the transferred BMDCs were pretreated with R406. These results demonstrate that Syk inhibition prevents allergen-induced AHR and airway inflammation after systemic sensitization and challenge, at least in part through alteration of DC function.
Topology-optimized silicon photonic wire mode (de)multiplexer (2015)

We have designed and for the first time experimentally verified a topology optimized mode (de)multiplexer, which demultiplexes the fundamental and the first order mode of a double mode photonic wire to two separate single mode waveguides (and multiplexes vice versa). The device has a footprint of ~4.4 μm x ~2.8 μm and was fabricated for different design resolutions and design threshold values to verify the robustness of the structure to fabrication tolerances. The multiplexing functionality was confirmed by recording mode profiles using an infrared camera and vertical grating couplers. All structures were experimentally found to maintain functionality throughout a 100 nm wavelength range limited by available laser sources and insertion losses were generally lower than 1.3 dB. The cross talk was around -12 dB and the extinction ratio was measured to be better than 8 dB.
Cloning, Analysis, and Chromosomal Localization of Myoxin (MYH12), the Human Homologue to the Mouse dilute Gene (1994)

The mouse dilute gene encodes a novel type of non-muscle myosin that structurally combines elements from both nonmuscle myosin type I and nonmuscle myosin type II. Phenotypically, mutations in the mouse dilute gene result not only in the lightening of coat color, but also in the onset of severe neurological defects shortly after birth. This may indicate that the mouse dilute gene is important in maintaining the normal neuronal function in the mouse. We report the isolation and sequencing of "myoxin" (MYH12), the human homologue of the mouse dilute gene, and its assignment to human chromosome 15.
FATS: Feature Analysis for Time Series (2015)

In this paper, we present the FATS (Feature Analysis for Time Series) library. FATS is a Python library which facilitates and standardizes feature extraction for time series data. In particular, we focus on one application: feature extraction for astronomical light curve data, although the library is generalizable for other uses. We detail the methods and features implemented for light curve analysis, and present examples for its usage.
AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper (2019)

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
Fully Differential Internal Electrostatic Transduction of a Lamé-Mode Resonator (2009)

This paper reports the parallel internal electrostatic transduction of a laterally driven Lame-mode polysilicon resonator. This resonator is fabricated using a manufacturable double nanogap process that provides ultrathin high-aspect ratio lateral gaps. The transduction electrodes are optimally placed and oriented to maximize electromechanical transduction efficiency for the fundamental Lame mode. A 128.15 MHz Lame-mode resonator is driven and sensed differentially with a 20 V DC polarization voltage: the motional resistance is about 30 kOmega and the quality factor Q > 12000 in air.
Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase (2023)

This study provides the first example of a strategy to design a practical ligand toward lysosomal acid α-glucosidase (GAA) focusing on <i>N</i>-alkyl derivatives of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB). The optimized <i>N</i>-4'-(<i>p</i>-trifluoromethylphenyl)butyl-DAB (<b>5g</b>) showed a <i>K</i><sub>i</sub> value of 0.73 μM, which was 353-fold higher affinity than <i>N</i>-butyl-DAB (<b>3f</b>) without a terminal phenyl group. Docking analysis showed that the phenyl part of <b>5g</b> was accommodated in a lipophilic pocket. Furthermore, the <i>p</i>-trifluoromethyl group effectively suppresses the fluctuation of the phenyl group, allowing it to produce a stable bonding form with GAA. <b>5g</b> increased the midpoint of the protein's protein denaturation temperature (<i>T</i><sub>m</sub>) by 6.6 °C above that in the absence of the ligand and acted as a "thermodynamic stabilizer" to improve the thermal stability of rhGAA. <b>5g</b> dose-dependently increased intracellular GAA activities in Pompe patient's fibroblasts with the M519V mutation; its effect was comparable to that of DNJ, which is under clinical trials.
Investigation of thickness effects on AlN coated metal tips by in situ I–V measurement (1999)

The effects of the aluminum nitride coating thickness on molybdenum emitter tips were investigated by an in situ I–V measurement technique inside a typical magnetron sputtering system. AlN was deposited on Mo tips using a dc-modulated 1 kW power source at 200 °C. Each I/V measurement was carried out immediately following a 15 s AlN deposition. Significantly improved field emission was observed as well as a strong emission thickness dependence, which we attribute to the influence of space charge.
In Vitro and In Vivo Antiviral Activity and Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor ABT-450 (2014)

The development of direct-acting antiviral agents is a promising therapeutic advance in the treatment of hepatitis C virus (HCV) infection. However, rapid emergence of drug resistance can limit efficacy and lead to cross-resistance among members of the same drug class. ABT-450 is an efficacious inhibitor of HCV NS3/4A protease, with 50% effective concentration values of 1.0, 0.21, 5.3, 19, 0.09, and 0.69 nM against stable HCV replicons with NS3 protease from genotypes 1a, 1b, 2a, 3a, 4a, and 6a, respectively. In vitro, the most common amino acid variants selected by ABT-450 in genotype 1 were located in NS3 at positions 155, 156, and 168, with the D168Y variant conferring the highest level of resistance to ABT-450 in both genotype 1a and 1b replicons (219- and 337-fold, respectively). In a 3-day monotherapy study with HCV genotype 1-infected patients, ABT-450 was coadministered with ritonavir, a cytochrome P450 3A4 inhibitor shown previously to markedly increase peak, trough, and overall drug exposures of ABT-450. A mean maximum HCV RNA decline of 4.02 log10 was observed at the end of the 3-day dosing period across all doses. The most common variants selected in these patients were R155K and D168V in genotype 1a and D168V in genotype 1b. However, selection of resistant variants was significantly reduced at the highest ABT-450 dose compared to lower doses. These findings were informative for the subsequent evaluation of ABT-450 in combination with additional drug classes in clinical trials in HCV-infected patients. (Study M11-602 is registered at ClinicalTrials.gov under registration no. NCT01074008.).
Online location recognition for drift-free trajectory estimation and efficient autonomous navigation (2017)

Autonomous navigation is a desired capability for mobile robotic platforms, such as UAVs and UGVs. Efficient autonomous navigation, especially in unknown environments, requires accurate localization based on online location recognition. Traditional monocular camera-based location recognition methods can suffer from accuracy, speed and robustness issues. In this paper, a novel online location recognition (OLR) algorithm based on fast and efficient interestpoint detection and feature-based keypoint matching is presented. The OLR incrementally constructs a database of visited locations and robustly recognizes revisited locations, even in complex and cluttered scenes. The OLR capability is quantitatively evaluated using a mobile robot setup in a multi-room office building environment. We further present and validate two applications based on the proposed OLR algorithm. In the first application, the OLR algorithm is integrated with conventional SLAM and an efficient trajectory correction algorithm for drift-free trajectory estimation (DTE) and qualitatively evaluated in the same environment. In the second application, the OLR algorithm is integrated with an exploration strategy for efficient autonomous navigation (EAN) and evaluated using a UAV model in a simulated warehouse environment. Our experiments demonstrate the accuracy and efficiency of the proposed location recognition algorithm and its utility for drift-free trajectory estimation and efficient autonomous navigation.
AoI-Penalty Minimization for Networked Control Systems with Packet Loss (2019)

In this work the impact of age of information (AoI) is studied from the perspective of networked control systems (NCS), i.e., control loops that are closed over networks. We formulate the estimation problem of a linear time invariant (LTI) system and show that related performance metrics can be optimized by minimizing age-penalty functions. From the variety of possible penalties that make sense from an NCS point of view, we derive a general age-penalty minimization problem. We characterize properties of penalty functions that are trivial or non-trivial to solve and show that for non-trivial age-penalties, the optimal transmission policy over a single link with packet loss is AoI-threshold based. Then, we propose an algorithm to find the optimal threshold. Simulation results verify that threshold policies with optimal threshold can serve to optimally solve a variety of NCS related estimation problems.
Torque quality and comparison of internal and external rotor axial flux surface-magnet disc machines (2002)

In this paper, pulsating torque components of PM machines and pulsating torque minimization techniques are discussed for axial flux surface magnet disc type PM machines. The pulsating torque analysis describing general instantaneous electromagnetic torque equation and torque ripple factor (TRF) is briefly given in order to analyze ripple torque of the machines. A detailed finite element analysis (FEA) focusing on the minimization of cogging and ripple torque components using some techniques are also provided. A detailed comparison of the two techniques is also illustrated in the paper.
Advances in prodrug design for Alzheimer’s disease: the state of the art (2022)

In the past 10 years, prodrugs have been approved by the FDA for the treatment of CNS pathologies. Most of them have been developed in order to improve membrane permeability of the parent drugs. Facing the limitation of AD drug discovery, the development of prodrugs will likely play a central role in the next years with the rise of innovative pleiotropic prodrugs.
Attosecond x-ray photonics: all-optical quasi-phase matching for high harmonic generation (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text O. Cohen, X. Zhang, A. L. Lytle, H. C. Kapteyn, and M. M. Murnane, "Attosecond x-ray photonics: all-optical quasi-phase matching for high harmonic generation," in Nonlinear Optics: Materials, Fundamentals and Applications, OSA Technical Digest (CD) (Optica Publishing Group, 2007), paper ThB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Biventricular strain analysis at 1.5T cardiac MR imaging: preliminary results in volunteers using an iterative SENSE reconstruction with L1 regularization (2014)

Background Changes in myocardial strain have been shown to precede onset of systolic dysfunction in patients with cardiomyopathy. Traditionally performed with echocardiography, acoustic windows can limit strain evaluation. Preliminary work has shown good agreement between myocardial strain derived from deformation field analysis at balanced steady-state free-precession (bSSFP) cine MRI and speckle tracking echocardiography. The application of a novel prototype iterative SENSE reconstruction with L1 regularization (IRSENSE) to highly accelerated segmented bSSFP cine acquisitions can maintain or improve the effective temporal resolution with a shorter breath-hold. The purpose of this study is to evaluate left- and right-ventricular stain analysis from bSSFP cine acquisitions using conventional GRAPPA and highly accelerated T-PAT with IR-SENSE. We hypothesize that myocardial strain parameters derived from accelerated T-PAT cine acquisitions with IR-SENSE are similar to those obtained using conventional segmented bSSFP with comparable effective temporal resolutions.
Development of novel immunotherapy based on nanoparticle co-delivering PLK1 and PD-L1 inhibitors for lung cancer treatment (2022)

Abstract Immune checkpoint inhibitors (ICIs) targeting PD-L1 and PD-1 have improved survival in a subset of patients with advanced non-small cell lung cancer (NSCLC). However, only a minority of NSCLC patients respond to ICIs, highlighting the need for superior immunotherapy. Herein, we developed a nanoparticle-based immunotherapy termed ARAC (Antigen Release Agent and Checkpoint Inhibitor) to enhance the efficacy of PD-L1 inhibitor. ARAC is a nanoparticle co-delivering PLK1 inhibitor (volasertib) and PD-L1 antibody. PLK1 is a key mitotic kinase that is overexpressed in various cancers including NSCLC and drives cancer growth. Inhibition of PLK1 selectively kills cancer cells and upregulates PD-L1 expression in surviving cancer cells thereby providing opportunity for ARAC targeted delivery in a positive feedback manner. ARAC reduced effective doses of volasertib and PD-L1 antibody by 5-fold in a metastatic lung tumor model (LLC-JSP) and the effect was mainly mediated by CD8 + T cells. Notably, ARAC also showed efficacy in another lung tumor model (KLN-205), which does not respond to CTLA-4 and PD-1 inhibitor combination. Further, the nanoparticle construct was well-tolerated in non-human primates. This study highlights a rationale combination strategy to augment existing therapies by utilizing our nanoparticle platform that can load multiple cargo types at once.
Reactions of trimethylphosphine analogs of auranofin with bovine serum albumin (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of trimethylphosphine analogs of auranofin with bovine serum albuminAnvarhusein A. Isab, C. Frank Shaw III, James D. Hoeschele, and James LockeCite this: Inorg. Chem. 1988, 27, 20, 3588–3592Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ic00293a029https://doi.org/10.1021/ic00293a029research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts