gebhart/patrepeval huggingface dataset:
Metabolites of the phospholipase D pathway regulate H2O2-induced filamin redistribution in endothelial cells (1998)

Hypoxia/reoxygenation injury to cultured endothelial cells results in cytoskeletal rearrangement and second messenger activation related to increased monolayer junctional permeability. Cytoskeletal rearrangement by reactive oxygen species may be related to specific activation of the phospholipase D (PLD) pathway. Human umbilical vein endothelial cell monolayers are exposed to H2O2 (100 microM) or metabolites of the PLD pathway for 1-60 min. Changes in cAMP levels, Ca2+ levels, PIP2 production, filamin distribution, and intercellular gap formation are then quantitated. H2O2-induced filamin translocation from the membrane to the cytosol occurs after 1-min H2O2 treatment, while intercellular gap formation significantly increases after 15 min. H2O2 and phosphatidic acid exposure rapidly decrease intracellular cAMP levels, while increasing PIP2 levels in a Ca2+-independent manner. H2O2-induced cAMP decreases are prevented by inhibiting phospholipase D. H2O2-induced cytoskeletal changes are prevented by inhibiting phospholipase D, phosphatidylinositol-4-phosphate kinase, phosphoinositide turnover, or by adding a synthetic peptide that binds PIP2. These data indicate that metabolites produced downstream of H2O2-induced PLD activation may mediate filamin redistribution and F-actin rearrangement.
Niedermolekulare Verbindungen als Inhibitoren Cyclin‐abhängiger Kinasen (2003)

Abstract Für multizelluläre Organismen ist die Zellteilung (Mitose) eine grundlegende Voraussetzung. Erst durch die Fähigkeit einer Zelle, sich zu replizieren, können komplexe Zellverbände entstehen. Fehlregulationen in den Kontrollmechanismen des Zellzyklus führen zu einer übermäßigen Zellproliferation und sind die Ursache für Krebs. Die Schlüsselstellung der Cyclin‐abhängigen Kinasen (CDKs) und ihrer direkten Mitspieler sowie die Tatsache, dass bei vielen malignen Erkrankungen Komponenten dieser zentralen Schrittmacher des Zellzyklus defekt sind, hat ein großes Interesse für die Entwicklung von niedermolekularen CDK‐Inhibitoren geweckt. Im Folgenden wird ein Überblick über die verschiedenen Strukturklassen ATP‐kompetitiver Inhibitoren für CDKs gegeben, die mit der Absicht entwickelt wurden, maligne Erkrankungen zu bekämpfen. Der Aufsatz zeigt, wie weit die Entwicklung von selektiven CDK‐Inhibitoren ist und inwiefern sich die Erwartungen in solche Wirkstoffe bisher erfüllt haben.
Identification of 19-nor-deoxycorticosterone in normal rat serum by enzyme immunoassay and gas chromatography-mass spectrometry. (1984)

Recent reports on the isolation and identification of 19-nor-deoxycorticosterone from the urine of rats with adrenal regeneration hypertension give rise to the possibility of a role of this steroid in the pathogenesis of low renin essential hypertension. The present study was undertaken to investigate the presence of 19-nor-deoxycorticosterone in normal rat serum both by a sensitive enzyme immunoassay and by gas chromatography-mass spectrometry (GC/MS). 19-Nor-deoxycorticosterone in rat serum was separated from other steroids prior to enzyme immunoassay by using high performance liquid chromatography (HPLC). The average concentration of 19-nor-deoxycorticosterone in normal rat serum was 137 +/- 62 ng/dl (mean +/- SD, n = 32). Pooled normal rat serum (50 ml) was purified by HPLC and the purified sample was acetylated with acetic anhydride for GC/MS measurement. The retention time and m/z ions (358, 285, and 257) on the resulting mass fragmentogram coincided in position with those of authentic 21-acetoxy-19-nor-deoxycorticosterone and acetylated normal rat serum extract. The combined characteristics of HPLC elution, antigen-antibody reaction, GC retention and selected ion responses provided strongly evidence supporting the presence of 19-nor-deoxycorticosterone in normal rat serum.
Feasibility of a vortex transistor (1985)

An experimental test is reported of the feasibility of developing a vortex transistor using tunnel junctions made from tin. (AIP)
Radionuclide Sensors for Water Monitoring (2003)

Radionuclide contamination in the soil and groundwater at U.S. Department of Energy (DOE) sites is a severe problem that requires monitoring and remediation. Radionuclide measurement techniques are needed to monitor surface waters, groundwater, and process waters. Typically, water samples are collected and transported to an analytical laboratory, where costly radiochemical analyses are performed. To date, there has been very little development of selective radionuclide sensors for alpha- and beta-emitting radionuclides such as 90Sr, 99Tc, and various actinides of interest. The objective of this project is to investigate novel sensor concepts and materials for sensitive and selective determination of beta- and alpha-emitting radionuclide contaminants in water. To meet the requirements for low-level, isotope-specific detection, the proposed sensors are based on radiometric detection. As a means to address the fundamental challenge of the short ranges of beta and alpha particles in water, our overall approach is based on localization of preconcentration/separation chemistries directly on or within the active area of a radioactivity detector. Automated microfluidics is used for sample manipulation and sensor regeneration or renewal. The outcome of these investigations will be the knowledge necessary to choose appropriate chemistries for selective preconcentration of radionuclides from environmental samples, new materials that combine chemical selectivity with scintillating properties, new materials that add chemical selectivity to solid-state diode detectors, new preconcentrating column sensors, and improved instrumentation and signal processing for selective radionuclide sensors. New knowledge will provide the basis for designing effective probes and instrumentation for field and in situ measurements.
The DLR MIRO: a versatile lightweight robot for surgical applications (2008)

Purpose Surgical robotics can be divided into two groups: specialized and versatile systems. Versatile systems can be used in different surgical applications, control architectures and operating room set‐ups, but often still based on the adaptation of industrial robots. Space consumption, safety and adequacy of industrial robots in the unstructured and crowded environment of an operating room and in close human robot interaction are at least questionable. The purpose of this paper is to describe the DLR MIRO, a new versatile lightweight robot for surgical applications. Design/methodology/approach The design approach of the DLR MIRO robot focuses on compact, slim and lightweight design to assist the surgeon directly at the operating table without interference. Significantly reduced accelerated masses (total weight 10 kg) enhance the safety of the system during close interaction with patient and user. Additionally, MIRO integrates torque‐sensing capabilities to enable close interaction with human beings in unstructured environments. Findings A payload of 30 N, optimized kinematics and workspace for surgery enable a broad range of possible applications. Offering position, torque and impedance control on Cartesian and joint level, the robot can be integrated easily into telepresence (e.g. endoscopic surgery), autonomous or soft robotics applications, with one or multiple arms. Originality/value This paper considers lightweight and compact design as important design issues in robotic assistance systems for surgery.
Low cost anti-soiling coatings for CSP collector mirrors and heliostats (2016)

Most concentrating solar power (CSP) facilities in the USA are located in the desert southwest of the country where land and sunshine are abundant. But one of the significant maintenance problems and cost associated with operating CSP facilities in this region is the accumulation of dust, sand and other pollutants on the collector mirrors and heliostats. In this paper we describe the development of low cost, easy to apply anti-soiling coatings based on superhydrophobic (SH) functionalized nano silica materials and polymer binders that posses the key requirements necessary to inhibit particulate deposition on and sticking to CSP mirror surfaces, and thereby significantly reducing mirror cleaning costs and facility downtime.
Algebra of Communicating Timing Charts for Describing and Verifying Hardware Interfaces (1997)

This paper addresses the specification and verification of hardware interface behaviors using an algebra of communicating timing charts (ACTC for short) whose underlying user model is the well known timing diagram. Terms modeling hierarchical timing charts are built in two steps. First, basic terms corresponding to the leaf charts are built, and then hierarchical terms are constructed using hierarchical operators. The basic terms model elementary behaviors as observed at the interface, and the hierarchical terms allow modeling behaviors at a higher level of abstraction: e.g., modeling an exception handling mechanism. We define an equivalence relation over the chart terms which is preserved by all the language constructs, and give a strategy to decide whether two deadlock-free basic terms are equivalent.
Threading dislocation reduction in strained layers (1999)

In this article, we have developed models for threading dislocation (TD) reduction due to the introduction of an intentionally strained layer. Three different types of dislocations have been considered in this model: misfit dislocations (MDs), mobile TDs, and TDs whose glide motion has been blocked by a MD crossing the glide path of the TD (immobile TDs). The models are based on MD formation by the process of lateral TD motion. The strain-induced TD motion leads to possible annihilation reactions of mobile TDs with either other mobile TDs or blocked TDs, or reactions in which a mobile TD is converted to an immobile TD by a blocking reaction with a MD. The evolution of the density of mobile and blocked TDs and the MD density is represented by three coupled nonlinear first order differential equations. When blocking of TDs by MDs is not considered, the equations have an analytical solution that shows that the final TD density should decrease exponentially where the argument of the exponent is proportional to the product of the reaction radius between TDs (the annihilation radius rA) and the nominal misfit strain εm. The no-blocking limit represents the maximum possible TD reduction through the introduction of a strained layer, regardless whether this layer has a discrete step in strain, step-grade, or continuous strain grading. When only blocking reactions are considered (no annihilation), again analytic solutions to the equations are obtained which show the maximum possible plastic strain relaxation for a discretely strained layer. Several examples of numerical solutions to the three coupled differential equations are described for cases that include both blocking and annihilation reactions.
The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone (2000)

α-Melanotropin (α-melanocyte stimulating hormone, α-MSH), Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, is one of the first peptide hormones isolated from the pituitary gland. The biologic functions of α-MSH and structure-activity relationships of α-MSH analogues before 1993 have been extensively researched and reviewed (1–12). This hormone plays a well-known and principal role in pigmentation. Other effects ascribed to this hormone include:
On the radial component of the electric field for a monopole phased array antenna focused in the near zone (1992)

The near-zone radial and principal spherical components of the electric field for a linear phased array antenna that is focused at one to two aperture diameters in the near zone are investigated. The phased array antenna consists of thin monopole elements, which are analyzed by using the method of moments. A theoretical formulation is described and computer simulation results are presented. The results show that the radial component is negligible in the focused near-field region, which allows the principal component to be accurately computed from knowledge of only the tangential electric field on the focal plane.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
NEW EUDESMENOIC ACID METHYL ESTER FROMARTEMISIA SELENGENSIS (2001)

The aerial parts of Artemisia selengensis yielded a new eudesmenoic acid methyl ester together with a known eudesmanolide. The structures were elucidated by spectroscopic methods. The relative stereochemistry of the title compound was further supported by the result of a successful single-crystal X-ray diffraction analysis.
Bricks (1995)

Article Bricks: laying the foundations for graspable user interfaces Share on Authors: George W. Fitzmaurice Dynamic Graphics Project, CSRI, University of Toronto, Toronto, Ontario, Canada M5S 1A4 Dynamic Graphics Project, CSRI, University of Toronto, Toronto, Ontario, Canada M5S 1A4View Profile , Hiroshi Ishii NTT Human Interface Lab, 1-2356 Take, Yokosuka-Shi, Kanagawa, 238-03 Japan NTT Human Interface Lab, 1-2356 Take, Yokosuka-Shi, Kanagawa, 238-03 JapanView Profile , William A. S. Buxton Dynamic Graphics Project, CSRI, University of Toronto, Toronto, Ontario, Canada M5S 1A4 and Alias Research Inc., 110 Richmond Street East, Toronto, Ontario, Canada M5C 1P1 Dynamic Graphics Project, CSRI, University of Toronto, Toronto, Ontario, Canada M5S 1A4 and Alias Research Inc., 110 Richmond Street East, Toronto, Ontario, Canada M5C 1P1View Profile Authors Info & Claims CHI '95: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsMay 1995 Pages 442–449https://doi.org/10.1145/223904.223964Online:01 May 1995Publication History 528citation5,214DownloadsMetricsTotal Citations528Total Downloads5,214Last 12 Months324Last 6 weeks32 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Fabrication of Long Scale Aluminum Foam by Transfer Heat Foaming of Precursor (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The Effect of Pulsed Current on the Lifetime of Lithium-ion Batteries (2021)

The pulsed current charging technique has been proposed to improve the charging performance and lifetime of Lithium-ion batteries. However, the optimal operating conditions of the pulsed current, e.g., profile, frequency, duty cycle, and amplitude, still need to be investigated. This work focuses on investigating the effect on the lifetime of Lithium-ion battery cells of the positive pulsed current (PPC) in the low-frequency range between 0.05 Hz and 1 Hz. According to the results of cycling aging tests, the PPC charging at 0.05 Hz can extend the lifetime up to 60% compared with the traditional constant current (CC) charging. Furthermore, a lifetime model of the battery cell in terms of the capacity fade and the increase in internal resistance is developed to estimate the effect of the PPC charging at different frequencies on the lifetime of the Lithium-ion battery cells.
MIMO and Massive MIMO - Analysis for a Local Area Scenario (2015)

The performance of centralized and distributed deployments of massive MIMO in an office building is analyzed both with and without cooperation. It is shown that using twice as many base station antennas as data streams provides most of the massive MIMO benefits. A simple transmission scheme achieves user fairness and operates close to a capacity upper bound. An example scheduling algorithm improves efficiency only for less than twice the number of base station antennas as data streams. The tradeoff between performance and cost for backhauling is evaluated by comparing cooperation of distributed base stations with a single central deployment.
Measurement of Liquid Turbulent Structure in Bubbly Flow at Low Void Fraction Using Ultrasonic Doppler Method (2003)

Microscopic structure in bubbly flows has been a topic of interest in the study of fluid dynamics. In the present paper, the ultrasonic Doppler method was applied to the measurement of bubbly. The experiments were carried out for an air-water dispersed bubbly flow in a 20 mm × 100 mm vertical rectangular channel having a void fraction smaller than 3%. Two ultrasonic transducers were installed on the outer surface of the test section with a contact angle of 45° off the vertical axis, one facing upward and the other facing downward. By applying statistical methods to the two directional velocity profiles, Reynolds stress profiles were calculated. Furthermore, to clarify the wake effect induced by the leading bubbles, the velocity profiles were divided into two types of data. The first one is for all of the liquid data and the other is the data which did not include the wake effect. For Rem ≥1,593, it was observed that the bubbles suppressed the liquid turbulence. Furthermore, comparing with the Reynolds stress profiles in bubbly flow, it was found that Reynolds stress profiles varied with the amount of bubbles present in the flow and the effect of wake causes turbulence in the liquid.
First Demonstration of 10-Gbit/s, 40-km SMF Transmission of an Uncooled 1.55-&#181;m InGaAlAs EA Modulator Integrated DFB Laser (2006)

A new uncooled 1.55-µm InGaAlAs electroabsorption-modulator integrated DFB laser suitable for 10-Gbit/s small-form-factor modules is demonstrated. For the first time, 10-Gbit/s 40-km SMF transmission with 1-dB power penalty is achieved from 0 to 85°C.
Near-infrared nano-spectroscopy of semiconductor quantum dots using a phase-change mask layer (2012)

We propose a technique that uses an optical mask layer of a phase-change material (PCM), which is used for rewritable optical recording media, to achieve highly sensitive near-field imaging spectroscopy of single semiconductor quantum constituents at optical telecommunication wavelengths. An amorphous nanoaperture allows imaging spectroscopy with a high spatial resolution and high collection efficiency. This is due to the large optical contrast between the crystalline and amorphous phases of the phase-change material at visible wavelengths and its high transparency at near-infrared wavelengths. We demonstrate the effectiveness of the method by numerical simulations and photoluminescence measurements of InAs/InP quantum dots.
ChemInform Abstract: Asymmetric Catalysis of 1,3‐Dipolar Cycloaddition Reactions: The Concepts of Activation and Induction of Asymmetry (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design and Synthesis of Heterocyclic Cations for Specific DNA Recognition: From AT-Rich to Mixed-Base-Pair DNA Sequences (2014)

The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove. Modifications were introduced in the original compound to include an H-bond accepting group to specifically recognize the G-NH that projects into the minor groove. Therefore, a series of heterocyclic cations substituted with an azabenzimidazole ring has been designed and synthesized for mixed-base-pair DNA recognition. The most successful compound, 12a, had an azabenzimidazole to recognize G and additional modifications for general minor groove interactions. It binds to the DNA site -AAAGTTT- more strongly than the -AAATTT- site without GC and indicates the design success. Structural modifications of 12a generally weakened binding. The interactions of the new compound with a variety of DNA sequences with and without GC base pairs were evaluated by thermal melting analysis, circular dichroism, fluorescence emission spectroscopy, surface plasmon resonance, and molecular modeling.
Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors (2014)

Tightly associated with blood vessels in their perivascular niche, human mesenchymal stem cells (MSCs) closely interact with endothelial cells (ECs). MSCs also home to tumours and interact with cancer cells (CCs). Microparticles (MPs) are cell-derived vesicles released into the extracellular environment along with secreted factors. MPs are capable of intercellular signalling and, as biomolecular shuttles, transfer proteins and RNA from one cell to another. Here, we characterize interactions among ECs, CCs and MSCs via MPs and secreted factors in vitro. MPs and non-MP secreted factors (Sup) were isolated from serum-free medium conditioned by human microvascular ECs (HMEC-1) or by the CC line HT1080. Fluorescently labelled MPs were prepared from cells treated with membrane dyes, and cytosolic GFP-containing MPs were isolated from cells transduced with CMV-GFP lentivirus. MSCs were treated with MPs, Sup, or vehicle controls, and analysed for MP uptake, proliferation, migration, activation of intracellular signalling pathways and cytokine release. Fluorescently labelled MPs fused with MSCs, transferring the fluorescent dyes to the MSC surface. GFP was transferred to and retained in MSCs incubated with GFP-MPs, but not free GFP. Thus, only MP-associated cellular proteins were taken up and retained by MSCs, suggesting that MP biomolecules, but not secreted factors, are shuttled to MSCs. MP and Sup treatment significantly increased MSC proliferation, migration, and MMP-1, MMP-3, CCL-2/MCP-1 and IL-6 secretion compared with vehicle controls. MSCs treated with Sup and MPs also exhibited activated NF-κB signalling. Taken together, these results suggest that MPs act to regulate MSC functions through several mechanisms.
Evaluation of neurodevelopmental deficits in children with HIV-1 infection (2005)

Abstract Children infected with human immunodeficiency virus type 1 (HIV-1) are at risk for developing central nervous system (CNS) disease characterized by impairments in cognitive, language, motor, and behavioral functions. The clinical presentation of pediatric HIV-1 CNS disease varies among patient subgroups as to the time of onset, rate of deterioration, severity of deficits, and number of domains affected (Belman 1994). CNS manifestations range from mild impairments in selective domains of cognitive functioning to the most severe form, referred to as HIV encephalopathy, in which children exhibit global and debilitating neurodevelopmental deficits with possible loss of previously acquired skills.
Supplementary Data from Molecular Mechanisms of Liver Carcinogenesis in the Mdr2-Knockout Mice (2023)

Supplementary Data from Molecular Mechanisms of Liver Carcinogenesis in the Mdr2-Knockout Mice
Hospitalization and Mortality in Hemodialysis Patients: Association with Hemoglobin Variability (2013)

Excursions below range were associated with negative outcomes, but excursions above range were either beneficial or neutral. Our findings indicate that clinicians should focus on low Hb as a negative indicator of patient status, whereas transient Hb above range is a marker for patient health and well-being.