gebhart/patrepeval huggingface dataset:
Fermi GF100 graphics processing unit (GPU) (2010)

This article consists of a collection of slides from the author's conference presentation on the NVIDIA Fermi GF family of GPU products. Some of the specific topics discussed include: the special features, system specifications, and system design for these products; system architectures; applications for use; platforms supported; processing capabilities; memory capabilities; and targeted markets.
Backbone-Assisted Wireless Local Area Network (2019)

This article presents a cross-layer design of backbone-assisted wireless local area network (WLAN) for dense WLAN deployment. The popularity of 802.11-based WLANs leads to dense WLAN deployment in geographically limited space, including dense access points (AP) and dense users. With dense APs, an AP could overhear packets destined for other APs. Backbone-assisted WLAN is a new system architecture where cooperative APs share the overheard packets through a backbone network, thereby reducing packet retransmission and improving system throughput. Conventional WLAN, such as Wi-Fi, uses Stop-and-Wait ARQ. This article argues that Stop-and-Wait does not work well with backbone-assisted WLAN because of large backbone delays. We first show that with a variant of Selective Repeat ARQ tailored for backbone-assisted WLAN, a single-user backbone-assisted WLAN system can achieve substantial throughput improvement over that with Stop-and-Wait ARQ. Then, we put forth a new system architecture targeted for dense users, referred to as network-coded backbone-assisted WLAN, in which multiple users are allowed to transmit simultaneously. A distinguishing feature of this system is the joint use of physical-layer network-coding (PNC) decoding and multiuser decoding (MUD) in multipacket reception. This article is the first attempt to design an ARQ for multiuser backbone-assisted WLAN. Our overall system design solves a PNC sequence obfuscation problem and addresses long packet latency in Selective Repeat ARQ. Experiments on our software-defined radio prototype indicate that network-coded Ethernet-backbone-assisted WLAN can achieve high system throughput and low packet latency. Specifically, the system throughput can outperform an MUD-only multiuser WLAN and a single-user WLAN by 60 and 100 percent, respectively. Overall, we believe that network-coded backbone-assisted WLAN is a viable solution for boosting throughput and reducing latency in dense WLAN environments.
Interactive Refinement and Editing for Time-Varying Mesh (2008)

This paper presents an automatic topology change detection and mesh editing interface for time-varying meshes (TVMs). TVM is a sequence of 3D mesh models of real-world objects generated by multiple-view images. The topology change detection is achieved by extracting skeletons from TVMs and tracking the motion of the skeletons. An interactive mesh editing tool is also developed. As a result, the time consistency of the mesh topology can be maintained, enabling us to apply a lot of mesh processing algorithms to TVM. The validity of our system is confirmed by applying the edited TVM sequence to motion tracking. Experimental results demonstrate that the tracking accuracy is improved by 393 mm in the best case.
Acknowledgment of Invited Editors (2016)

On behalf of the Editors of mBio, I gratefully acknowledge the following individuals, who served as Invited Editors for the journal in 2015. While not members of the Board of Editors, Invited Editors serve an important role in the review process. Invited Editors are experts in their fields of research who add an additional level of quality to the review process. An Editor may assign a paper to an Invited Editor when he/she would like to have an additional expert opinion of the reviews or when the subject area falls outside the Editor’s primary area of expertise.
New Polymeric Inhibitor of Galactosyl Transferase1 (1997)

Abstract 2′,3′-Di-O-acetyluridine 5′-p-styrenesulfonate was synthesized by the reaction of 2′,3′-di-O-acetyluridine with p-styrenesulfonyl chloride and polymerized. After removal of acetyl groups, the polymeric product was shown by NMR spectroscopy and gel permeation chromatography to be poly(uridine 5′-p-styrenesulfonate). This uridine-containing polymer was tested against the galactosyl transferase that synthesizes lactose in the presence of α-lactalbumin. The polymeric compound did inhibit the enzyme with 75% inhibition requiring 120 μM which is only one percent of the concentration of glycosyl donor substrate (UDP-galactose, 12 mM).
Power Penalty Measurement and Frequency Chirp Extraction in Silicon Microdisk Resonator Modulators (2010)

We demonstrate 5Gbs and 10Gbs error free operation of silicon photonic microdisk resonant modulators to a distance of 70km, measure dispersion power penalties and compare the experimental results with theoretically derived values.
The Effect of the P1 Side Chain on the Binding of Optimized Carboxylate and Activated Carbonyl Inhibitors of the Hepatitis C Virus Ns3 Protease (2010)

Peptidyl inhibitors of the hepatitis C virus NS3 protease hold much promise as direct-acting antiviral agents against hepatitis C infection. The optimization of N-terminal cleavage products, found to exhibit activity (product inhibition) against the enzyme, has led to potent tripeptide inhibitors that bear free C-terminal carboxylate groups. An analogous activated carbonyl compound (pentafluoroethyl ketone) bearing a P1 norvaline (Nva) was found to possess comparable activity against hepatitis C virus protease. However, an analogue bearing an aminocyclopropylcarboxylic acid (Acca) P1 residue exhibited very poor activity. (19)F-NMR studies indicate that the propensity of the Acca-derived activated carbonyl to form hemiketals is only slightly reduced compared with that of a P1 Nva equivalent. These results, as well as molecular modeling studies, argue against steric hindrance of the nucleophilic attack of Ser-139 accounting for the poor mechanism-based inhibition by the former. We hypothesize that the conformational properties of the respective C-termini in the context of an adaptable active site account for the divergent P1 structure-activity relationships.
Data from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The goal of this research was to harness a monoclonal antibody (mAb) discovery platform to identify cell-surface antigens highly expressed on cancer and develop, through Fc optimization, potent mAb therapies toward these tumor-specific antigens.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Fifty independent mAbs targeting the cell-surface immunoregulatory B7-H3 protein were obtained through independent intact cell-based immunizations using human tissue progenitor cells, cancer cell lines, or cell lines displaying cancer stem cell properties. Binding studies revealed this natively reactive B7-H3 mAb panel to bind a range of independent B7-H3 epitopes. Immunohistochemical analyses showed that a subset displayed strong reactivity to a broad range of human cancers while exhibiting limited binding to normal human tissues. A B7-H3 mAb displaying exquisite tumor/normal differential binding was selected for humanization and incorporation of an Fc domain modified to enhance effector-mediated antitumor function via increased affinity for the activating receptor CD16A and decreased binding to the inhibitory receptor CD32B.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; MGA271, the resulting engineered anti–B7-H3 mAb, mediates potent antibody-dependent cellular cytotoxicity against a broad range of tumor cell types. Furthermore, in human CD16A-bearing transgenic mice, MGA271 exhibited potent antitumor activity in B7-H3–expressing xenograft models of renal cell and bladder carcinoma. Toxicology studies carried out in cynomolgus monkeys revealed no significant test article-related safety findings.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This data supports evaluation of MGA271 clinical utility in B7-H3–expressing cancer, while validating a combination of a nontarget biased approach of intact cell immunizations and immunohistochemistry to identify novel cancer antigens with Fc-based mAb engineering to enable potent antitumor activity. &lt;i&gt;Clin Cancer Res; 18(14); 3834–45. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Spinal segments do not move together predictably during daily activities (2018)

The results suggest that multi-segmental analysis of the spine is necessary if spine movement characteristics are to be fully understood. We cannot establish a priori where redundancy occurs based on healthy data, therefore extra consideration should be made when planning studies with pathological cohorts.
Phase 1/1b study of PRGN-3005 autologous UltraCAR-T cells manufactured overnight for infusion next day to advanced stage platinum resistant ovarian cancer patients. (2023)

5590 Background: Relapsed or refractory (r/r) ovarian cancer patients (pts) have limited treatment options. PRGN-3005 UltraCAR-T cells express a chimeric antigen receptor (CAR) targeting unshed MUC16, membrane bound IL-15 (mbIL15) and a kill switch with robust activity in preclinical models. UltraCAR-T investigational therapies are manufactured overnight using the proprietary UltraPorator electroporation system at the medical center and administered to patients one day after gene transfer. Methods: The Phase 1/1b study of PRGN-3005 evaluates the safety and recommended Phase 2 dose (RP2D) of PRGN-3005 in pts with r/r ovarian cancer (NCT03907527). In Phase 1, pts received PRGN-3005 without lymphodepletion (LD) via Intraperitoneal (IP) infusion (Cohort 1, C1) or Intravenous (IV) infusion (Cohort 2, C2) at Dose level 1-3. Dose level 3, IV infusion was further evaluated in pts treated with cyclophosphamide LD (60mg/kg/day on days -4 to -3 (IV LD)). As of the February 6, 2023 data cut-off, 25 evaluable pts have been treated in C1 (n = 12), C2 (n = 6), and IV LD (n = 7). Pts had a median age of 64 years (38-76) and were heavily pre-treated with a median of 8 prior regimens (4-11). Pts treated in C1 received 1 to 65.5 x 10 5 cells/kg, pts treated in C2 received 0.1 to 50 x 10 5 cells/kg and pts treated in IV LD received 0.1 to 39 x 10 5 cells/kg. Results: PRGN-3005 was well tolerated at up to 65.5 x 10 5 cells/kg. There have been no deaths, dose-limiting toxicities, neurotoxicity, grade ≥3 Cytokine Release Syndrome (CRS), or unexpected on-target/off-target toxicities related to PRGN-3005, and no use of the kill switch as of data cut-off. Grade 1 CRS occurred in 3/7 IV LD pts and one pt had transient grade 2 CRS, which resolved in &lt; 24 hours. Plasma levels of IL-15 did not increase with treatment confirming mbIL15 is not shed. A dose dependent increase in PRGN-3005 was observed in peripheral blood of patients even in the absence of LD, and i n vivo persistence of PRGN-3005 could be observed in some patients for up to 9 months post infusion. Response was evaluated per RECIST 1.1, and 20% of all subjects experienced a response in at least 1 target lesion. In the IV LD pts, the disease control rate (DCR) was 85.7% at first restaging, with a decreased target tumor burden in 4/7 (57%), and a 27.4% average decrease in CA125. One pt had a 28% decrease in target tumor burden after receiving a second infusion of PRGN-3005 after 12 months. Conclusions: PRGN-3005 UltraCAR-T targeting MUC16 has been well tolerated with minimal toxicity. PRGN-3005 demonstrated a dose-dependent expansion and persistence in blood with or without LD. Encouraging DCR rates and a reduction in overall tumor burden have been observed in heavily pretreated, ovarian cancer pts treated with LD. The study continues to enroll to the Phase 1b expansion phase and is treating pts at DL3 with LD with an option to receive a second dose. Clinical trial information: NCT03907527 .
Effectiveness Assessment of Solid-State Drive Used in Big Data Services (2014)

Big data poses challenges to the technologies required to process data of high volume, velocity, variety, and veracity. Among the challenges, the storage and computing required by big data analytics is usually huge, and as a result big data capabilities are often provisioned in cloud and delivered in the form of Web-based services. Solid-state drive (SSD) is widely used nowadays as an elementary hardware feature in cloud infrastructure for big data services. For example, Amazon Web Service (AWS) offers EC2 instances with SSD storage, and its key-value data store, DynamoDB, is backed up by SSD for superior performance. Compared to hard disk drive (HDD), SSD prevails in both access latency and bandwidth. In the foreseeable future, SSD would be readily available on commodity servers though its capacity would be neither large enough nor cost effective to accommodate big data on its own. Therefore, it is essential to investigate how to efficiently leverage SSD as one layer in a storage hierarchy in addition to HDD. In this paper, we investigate the effectiveness of using SSD in three workloads, namely standalone Hadoop MapReduce jobs, Hive jobs, and HBase queries. Firstly, we device an approach to enable Hadoop Distributed File System (HDFS) having a SSD-HDD storage hierarchy. Secondly, we investigate the IO involved in different phases of Hadoop jobs and design different schemes to place data discriminatively in the aforementioned storage hierarchy. Afterward, the effectiveness of different schemes are evaluated with respect to job run time. Finally, we summarize best practices of data placement for examined workloads in a SSD-HDD storage hierarchy.
[The carbohydrate deficient glycoprotein syndrome]. (1991)

The carbohydrate-deficient glycoprotein syndrome is a newly described hereditary disorder which may be due to a defect in the glycoprotein metabolism. Predominant symptoms are mental retardation, epilepsy, cerebellar ataxia, polyneuropathy, squint, retinitis pigmentosa, retarded growth, hypothyroidism and liver steatosis. Increased serum glycoprotein-deficient transferrin is a marker of the disease and confirms the diagnosis. We describe four Norwegian children with this syndrome. Olivopontocerebellar degeneration was found upon examination of the brain in two patients who died.
Extrinsic self-trapping and negativeUin semiconductors: A metastable center in InP (1984)

A fascinating electron-irradiation-induced defect (the $M$ center) in $n$-type InP has been reported recently. Two entirely different capacitance transient spectra can be obtained for this center in the same sample (a $p\ensuremath{-}n$ junction diode) depending upon its bias condition during the cool down to the initial measurement temperature (~ 30 K). We present a conceptually simple configuration-coordinate model that explains the unusual properties of this center. In our model the metastable center can exist in either of two configurations, one which displays a very large lattice relaxation, and another ordinary (no anomalously large lattice relaxation) configuration. Photoionization rates have been measured for the defect levels of the two different defect configurations as a function of photon energy. These data are used to confirm the qualitative properties of our model and to determine its parameters. Classification of the $M$-center behavior within the general context of selftrapped configurations is proposed.
Symmetry-based Design and Fabrication of Novel Sensor Systems (2011)

Coupled systems of differential equations are often used as models of physical systems. For example they have been used by Hadley and Aronson to model arrays of Josephson junctions, by Kopell and Ermentrout and Rand to model coupled oscillators and central pattern generators (CPGs) in biological systems, by Pecora and Caroll to investigate synchronization of chaotic oscillators, and, more recently, by Susuki, Takatsuji, and Hikihara to study power grid systems. In these works the symmetry of the network is important in determining the patterns of collective behavior that the system can support. One particular pattern of behavior that is commonly found in symmetric coupled systems is cycling behavior, in which solution trajectories can linger around steady states and periodic solutions for increasingly longer periods of time. In this paper we discuss the existence and stability of heteroclinic cycles in coupled systems and show how they can be exploited to design and fabricate a new generation of highly‐sensitive, self‐powered, sensor devices. We present theoretical and experimental proof of concept that coupling‐induced oscillations located near the bifurcation point of a heteroclinic cycle can significantly enhance the sensitivity of an array of sensors, including: fluxgate magnetometers, electric‐field sensors, Superconducting Quantum Interference Devices, and Gyroscopes.
Piezoelectric fields in GaInN∕GaN quantum wells on different crystal facets (2006)

Direction and strength of piezoelectric built-in fields of GaInN quantum wells have been experimentally determined. The quantum wells have been grown either on the conventional {0001} crystal plane of GaN or on {11¯01} facets of selectively grown GaN stripes. The emission peak position of the electric-field-dependent photoluminescence can be modeled and yields value and sign of the piezoelectric field dependent on the strain of the quantum wells. On the semipolar {11¯01} facets, the quantum wells show a much weaker field (−0.1MV∕cm) compared to quantum wells grown on polar {0001} planes (−1.9MV∕cm), consistent with theoretic predictions.
Supplementary Figures 1-6 from Downregulation of Sec23A Protein by miRNA-375 in Prostate Carcinoma (2023)

Supplementary Figures 1-6 from Downregulation of Sec23A Protein by miRNA-375 in Prostate Carcinoma
Preclinical Molecular Imaging of the Translocator Protein (TSPO) in a Metastases Model Based on Breast Cancer Xenografts Propagated in the Murine Brain (2012)

Previous studies have demonstrated the feasibility of translocator protein (TSPO) imaging to visualize and quantify human breast adenocarcinoma (MDA-MB-231) cells in vivo using a TSPO-targeted near-infrared (NIR) probe (NIR-conPK11195). This study aimed to extend the use of the TSPO-targeted probe to a more biologically relevant and clinically important tumor microenvironment as well as to assess our ability to longitudinally detect the presence and progression of breast cancer cells in the brain. The in vivo biodistribution and accumulation of NIR-conPK11195 and free (unconjugated) NIR dye were quantitatively evaluated in intracranial MDA-MB-231-bearing mice and non-tumor-bearing control mice longitudinally once a week from two to five weeks post-inoculation. The in vivo time-activity curves illustrate distinct clearance profiles for NIR-conPK11195 and free NIR dye, resulting in preferential accumulation of the TSPO-targeted probe in the intracranial tumor bearing hemisphere (TBH) with significant tumor contrast over normal muscle tissue (p < 0.005 at five weeks; p < 0.01 at four weeks). In addition, the TSPO-labeled TBHs demonstrated significant contrast over the TBHs of mice injected with free NIR dye (p < 0.001 at four and five weeks) as well as over the TSPO-labeled non-tumor-bearing hemispheres (NTBHs) of control mice (p < 0.005 at four and five weeks). Overall, TSPO-targeted molecular imaging appears useful for visualizing and quantifying breast cancer xenografts propagated in the murine brain and may assist in preclinical detection, diagnosis and monitoring of metastatic disease as well as drug discovery. Furthermore, these results indicate it should be possible to perform TSPO-imaging of breast cancer cells in the brain using radiolabeled TSPO-targeted agents, particularly in light of the fact that [11C]-labeled TSPO probes such as [11C]-PK 11195 have been successfully used to image gliomas in the clinic.
Microstructure and ionic resistivity of calcium-containing sodium beta alumina (1979)

Calcium containing sodium beta aluminas were prepared, and their microstructure and ionic resistivity was studied.The calcium significantly promotes abnormal grain growth at temperatures above 1700 o C, and leads to the formation of highly blocking intergranular calcium aluminate phases.Evidence was also found for partial solution of calcia in a-alumina.The D.C. resistivity, p, at 300C was found to increase exponentially with calcium content [C] leading to a relationship of the type: log (p/po)= BO[C], where the proportionality factor B depends on the sintering conditions.
On Inherent Redundancy of MMC-Based STATCOMs in the Overmodulation Region (2019)

Modular multilevel converters (MMCs) are frequently featured to their modular structure, which results in fault-tolerant operation and easy redundancy realization. Nevertheless, in order to reach a given redundancy factor, more cells must be included in the converter, which directly affects the costs. This paper discusses the inherent redundancy of a modular multilevel converter (MMC) based static synchronous compensator (STATCOM) operating in the overmodulation region. Analytical expressions for the limits of the converter linear region were developed in order to define the minimum required dc-link voltage. Moreover, sensitivity analyses were implemented in order to show the effects of grid voltage variations, different output impedances, power factor and injected currents. The results indicated that the operation in overmodulation region has significant inherent redundancy. For a MMC based STATCOM with 26 cells, the converter can ride through 4 failures per arm without significantly increasing the output THD or reducing the injected current into the grid.
Seamless W-Band Radio-to-Optical Signal Conversion with Direct IQ Down-Converter (2014)

Seamless conversion from millimeter-wave radio signals to optical baseband signals was demonstrated using a direct IQ down-converter. Hybrid optical and millimeter-wave signal transmission was performed using a conventional digital-coherent receiver, without any special algorithms.
Reduction of recording noise caused by nano-scale variations in Curie temperature (2019)

Heat-Assisted Magnetic Recording (HAMR) is expected to be the next-generation magnetic recording technology: it is designed to meet increasing higher areal density demands from cloud storage. Until now, there are no feasible solutions to address nm-scale Curie temperature variance in FePt-based single layer media. This variance is the leading noise source, and thus limits further development of HAMR technology. Here, we describe a superparamagnetic write process that can greatly mitigate the impact of Curie temperature variance by recording information at the blocking temperature of the magnetic material. To demonstrate the benefits of this write process, we employ a bilayer structure with a superparamagnetic write layer and FePt as a long-term storage layer. By developing the theory behind the recording mechanism, we are able to introduce design rules addressing the importance of elevated Curie temperature in the write layer and optimization of quantum mechanical coupling between the two functional layers.