gebhart/patrepeval huggingface dataset:
Supercritical water conversion of glycerol : comparative parametric study between batch and continuous process (2011)

• Glycerol, a main by-product of the biodiesel production, has a high valorization potential. This paper proposes a comparison of hydrogen production from glycerol using batch (5 mL and 500 mL) and continuous (100 mL) processes. The influence of different operating parameters has been studied: temperature (450°C-600°C), pressure (20-28MPa), glycerol concentration (5-20wt%), catalyst concentration (K 2 CO 3 or NaOH, 0-5 wt%), reaction time (5-120 min, batch), residence time (12 min, continuous process), stirring rate (500-1500 rpm, batch of 500ml), and heating rate (50% and 100% of heating power). • Quantitative glycerol conversion has been observed: until 99% of TOC removal by SCWG. While the amount of solid formed is insignificant, the produced gas volume reached 43 L gas/L solution (5 wt% glycerol) with a molar composition up to 60% H 2 and 30% CO 2 (atmospheric pressure). Various proportions of CH 4 , C 2 H 6 and C 2 H 4 have been observed. Catalyst contribution to the gasification yield of glycerol is relevant. • SCW conversion of glycerol, quantitative by-product in biodiesel industry, into hydrogen is a sustainable process. The yield obtained in the continuous laboratory reactor (3 mol H 2 /L of reactor/h) under homogeneous catalysis (K salts, low concentrations) recommends the process for further research and pilot development.
Figure S4 from An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer (2023)

&lt;p&gt;A) FDR-corrected shared and unique ChIP peaks of AIB1 and AIB1Î"4 in MCF10A parental cell line (10A) versus AIB1Î"4-expressing isogenic line (10A-Î"4). Shared peaks have at least 1bp overlap. B) AIB1 ChIP peaks in MCF7 cells treated for 3 hours with estradiol (E2) or vehicle (V) overlapped with MCF10A and MCFDCIS (parental and AIB1Î"4 derivative lines). MCF7 data set obtained from Zwart et al(32). C) Motifs within 200 bp of the peak summit for significant ChIP-Seq peaks were analyzed for motif enrichment using HOMER. In red are the motifs unique to AIB1Î"4 in MCF10A cells. D) FDR-corrected histone modification peaks in DCIS and DCIS-Î"4 overlapping with enhancer sites from human mammary epithelial cells (hMEC enh.) (42). E) The distribution of AIB1, H3K27ac or H3K4me1 ChIP peaks 500 kb up- and downstream of gene transcription start site (TSS). Genomic distance was divided into 5kb bins.&lt;/p&gt;
Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics (2023)

Supplementary Figure 1, Table 1 from Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of β-tubulin at Cys 12 and suppression of microtubule dynamics
Genetic-Algorithm Assisted Design of C-band Photonic-Crystal Waveguide Interleavers Using Ring Resonators (2009)

We investigate the optimization of C-band photonic-crystal waveguide (PCW) interleavers in different implementations using coupled-resonator optical waveguide (CROW) ring resonators. Genetic algorithms (GAs) are employed to optimize the filters for high transmittivity and flatness.
Gaseous Nitrogen and Carbon Emissions from a Full‐Scale Deammonification Plant (2010)

The aim of this work was to give a quantitative description of the gaseous nitrogen and carbon emissions of a full-scale deammonification plant (DEMON system). Deammonification accounted for the net carbon sequestration of 0.16 g CO2/g NO2-N. Both nitrogen dioxide (NO2) and nitric oxide (NO) were minor trace gases (<0.1% nitrogen output). However, in comparison, the nitrous oxide (N2O) emission (1.3% nitrogen output) was significant. The global warming potential of the N2O emissions from the DEMON were similar to those found in conventional simultaneous nitrification/denitrification systems; however, CO2 emissions in the investigated system were significantly lower, thereby lessening the overall environmental effect. This was the first time such an analysis has been performed on a DEMON system.
ChemInform Abstract: Phase‐Vanishing Methods Based on Fluorous Phase Screen: A Simple Way for Efficient Execution of Organic Synthesis (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Effect of Player Contact Characteristics on Head Impact Exposure in Youth Football Games (2021)

To reduce head impact exposure (HIE) in youth football, further understanding of the context in which head impacts occur and the associated biomechanics is needed. The objective of this study was to evaluate the effect of contact characteristics on HIE during player versus player contact scenarios in youth football. Head impact data and time-synchronized video were collected from 4 youth football games over 2 seasons in which opposing teams were instrumented with the Head Impact Telemetry (HIT) System. Coded contact characteristics included the player's role in the contact, player speed and body position, contact height, type, and direction, and head contact surface. Head accelerations were compared among the contact characteristics using mixed-effects models. Among 72 instrumented athletes, 446 contact scenarios (n = 557 impacts) with visible opposing instrumented players were identified. When at least one player had a recorded impact, players who were struck tended to have higher rotational acceleration than players in striking positions. When both players had a recorded impact, lighter players and taller players experienced higher mean head accelerations compared with heavier players and shorter players. Understanding the factors influencing HIE during contact events in football may help inform methods to reduce head injury risk.
First transcriptomic analysis of the economically important parasitic nematode, Trichostrongylus colubriformis, using a next-generation sequencing approach (2010)

Trichostrongylus colubriformis (Strongylida), a small intestinal nematode of small ruminants, is a major cause of production and economic losses in many countries. The aims of the present study were to define the transcriptome of the adult stage of T. colubriformis, using 454 sequencing technology and bioinformatic analyses, and to predict the main pathways that key groups of molecules are linked to in this nematode. A total of 21,259 contigs were assembled from the sequence data produced from a normalized cDNA library; 7876 of these contigs had known orthologues in the free-living nematode Caenorhabditis elegans, and encoded, amongst others, proteins with 'transthyretin-like' (8.8%), 'RNA recognition' (8.4%) and 'metridin-like ShK toxin' (7.6%) motifs. Bioinformatic analyses inferred that relatively high proportions of the C. elegans homologues are involved in biological pathways linked to 'peptidases' (4%), 'ribosome' (3.6%) and 'oxidative phosphorylation' (3%). Highly represented were peptides predicted to be associated with the nervous system, digestion of host proteins or inhibition of host proteases. Probabilistic functional gene networking of the complement of C. elegans orthologues (n=2126) assigned significance to particular subsets of molecules, such as protein kinases and serine/threonine phosphatases. The present study represents the first, comprehensive insight into the transcriptome of adult T. colubriformis, which provides a foundation for fundamental studies of the molecular biology and biochemistry of this parasitic nematode as well as prospects for identifying targets for novel nematocides. Future investigations should focus on comparing the transcriptomes of different developmental stages, both genders and various tissues of this parasitic nematode for the prediction of essential genes/gene products that are specific to nematodes.
Habitual micronutrient intake during and after pregnancy in Caucasian Londoners (2008)

Micronutrient status is of fundamental importance both upon conception and throughout pregnancy. There is an abundance of literature investigating nutrient intakes during individual trimesters of pregnancy but few studies have investigated baseline intakes of nutrients throughout gestation as a continuum. The current investigation set out to measure habitual micronutrient intakes at weeks 13, 25, 35 of pregnancy and 6 weeks postpartum using a prospective background information questionnaire, 4-7-day weighed food diary and postnatal questionnaire. Seventy-two primiparous, Caucasian Londoners were recruited at the study start with 42 completing the first, second, third trimester and postpartum study stages respectively. Study findings indicated that sodium intakes were significantly higher than UK guidelines throughout and after pregnancy (P < 0.001). Intakes of folate, iron, vitamin D, potassium, iodine and selenium were lower than UK recommendations during and after pregnancy, but to varying levels of statistical significance (P < 0.05). Only 23-38% of women met UK recommendations for folate (300 microg day(-1)) through dietary sources. Similarly, only a small percentage of women met dietary guidelines for iron (19-28%). The findings from the current study indicate that public health interventions may be required to help expectant mothers achieve an optimal diet, particularly after birth when dietary recommendations increase for some micronutrients.
Supplementary Legend from Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model (2023)

Supplementary Legend from Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model
Overexpression of AtMYB44 Enhances Stomatal Closure to Confer Abiotic Stress Tolerance in Transgenic Arabidopsis (2007)

AtMYB44 belongs to the R2R3 MYB subgroup 22 transcription factor family in Arabidopsis (Arabidopsis thaliana). Treatment with abscisic acid (ABA) induced AtMYB44 transcript accumulation within 30 min. The gene was also activated under various abiotic stresses, such as dehydration, low temperature, and salinity. In transgenic Arabidopsis carrying an AtMYB44 promoter-driven beta-glucuronidase (GUS) construct, strong GUS activity was observed in the vasculature and leaf epidermal guard cells. Transgenic Arabidopsis overexpressing AtMYB44 is more sensitive to ABA and has a more rapid ABA-induced stomatal closure response than wild-type and atmyb44 knockout plants. Transgenic plants exhibited a reduced rate of water loss, as measured by the fresh-weight loss of detached shoots, and remarkably enhanced tolerance to drought and salt stress compared to wild-type plants. Microarray analysis and northern blots revealed that salt-induced activation of the genes that encode a group of serine/threonine protein phosphatases 2C (PP2Cs), such as ABI1, ABI2, AtPP2CA, HAB1, and HAB2, was diminished in transgenic plants overexpressing AtMYB44. By contrast, the atmyb44 knockout mutant line exhibited enhanced salt-induced expression of PP2C-encoding genes and reduced drought/salt stress tolerance compared to wild-type plants. Therefore, enhanced abiotic stress tolerance of transgenic Arabidopsis overexpressing AtMYB44 was conferred by reduced expression of genes encoding PP2Cs, which have been described as negative regulators of ABA signaling.
Expression and activity of hexokinase in the early mouse embryo (1996)

The maximal activity and Michaelis constant, KM, of hexokinase have been measured in the peri-implantation mouse embryo using an ultramicrofluorescence technique. In addition, transcript detection of the predominant isoenzyme hexokinase I has been determined in single preimplantation mouse embryos at successive stages of development using reverse transcriptase-mediated cDNA amplification. Maximal hexokinase activity decreased dramatically peri-implantation, from 0.97 +/- 0.19 nmol/microgram protein/h at the blastocyst stage to 0.31 +/- 0.05 nmol/microgram protein/h on day 6.5. The KM remained relatively low and constant over this period (0.23-0.39 mM), indicating the absence of the hexokinase type IV isoenzyme. The pattern of hexokinase activity resembled that of glucose consumption suggesting a possible regulatory role for the enzyme during this period of development. Hexokinase I mRNA was detected in the oocyte and all preimplantation stages of development. The blastocyst polymerase chain reaction (PCR) product, when cloned and sequenced was found to be 98% homologous with mouse tumour hexokinase I. Taken together, these data suggest that the hexokinase gene is not under transcriptional control during early mouse embryo development but plays a significant role in the regulation of glucose consumption. A role for hexokinase in the phosphate-induced inhibition of early embryo development is also proposed.
ChemInform Abstract: Recent Advances in Multidentate Anion Complexation (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Using Ultrawide Field-Directed Optical Coherence Tomography for Differentiating Nonproliferative and Proliferative Diabetic Retinopathy (2023)

UWF-directed OCT may offer a noninvasive alternative to detect NVE in eyes with DR.
Coupled-core multi-core fibers: High-spatial-density optical transmission fibers with low differential modal properties (2015)

The characteristics of coupled-core multi-core fibers (CC-MCF) are reviewed. Random mode coupling and low differential group delay properties of the CC-MCF are discussed, and relationships between differential modal group delay, bends, and twists are also investigated.
Gene Deletions in Mycobacterium bovis BCG Stimulate Increased CD8+T Cell Responses (2014)

Mycobacteria, the etiological agents of tuberculosis and leprosy, have coevolved with mammals for millions of years and have numerous ways of suppressing their host's immune response. It has been suggested that mycobacteria may contain genes that reduce the host's ability to elicit CD8(+) T cell responses. We screened 3,290 mutant Mycobacterium bovis bacillus Calmette Guerin (BCG) strains to identify genes that decrease major histocompatibility complex (MHC) class I presentation of mycobacterium-encoded epitope peptides. Through our analysis, we identified 16 mutant BCG strains that generated increased transgene product-specific CD8(+) T cell responses. The genes disrupted in these mutant strains had disparate predicted functions. Reconstruction of strains via targeted deletion of genes identified in the screen recapitulated the enhanced immunogenicity phenotype of the original mutant strains. When we introduced the simian immunodeficiency virus (SIV) gag gene into several of these novel BCG strains, we observed enhanced SIV Gag-specific CD8(+) T cell responses in vivo. This study demonstrates that mycobacteria carry numerous genes that act to dampen CD8(+) T cell responses and suggests that genetic modification of these genes may generate a novel group of recombinant BCG strains capable of serving as more effective and immunogenic vaccine vectors.
Femtosecond Absorption Studies of Nonequilibrium Electronic Processes in High-Tc Superconductors (1990)

The time resolution of nonequilibrium electron processes using short laser pulses has produced important information regarding the thermal properties of the carriers and phonons in metals 1 - 2 . Recently the use of short laser pulses (~ 8 ps) has been used to study the electron-phonon relaxation rate in single crystal, non-superconducting lanthanum cuprate 3 . The authors found nonequilibrium heating to occur on a picosecond time scale. In this paper we present for the first time, evidence of nonequilibrium heating on a single picosecond time scale in epitaxial thin-film samples of the compounds YBa 2 Cu 3 O 7-x (0 &lt; x &lt; 0.6) and Bi 2 Sr 2 Ca 2 Cu 3 O 10 .
The ring contraction of δ-lactones with leaving group α-substituents: a strategy for the synthesis of 2,5-disubstituted highly functionalised homochiral tetrahydrofurans (1992)

Treatment of derivatives of δ-lactones having a leaving group at C-2 with methanol in the presence of base gives methyl tetrahydrofuran-α-carboxylates in good to excellent yield with a high degree of stereocontrol of the carbon substituents at C-2 and C-5.
A mannose-6-phosphonate–cholesterylamine conjugate as a specific molecular adhesive linking cancer cells with vesicles (2001)

A hydrolytically stable sugar phosphonate coupled to a steroid via a long and semi-rigid spacer (synthesized via a 12-step sequence) binds both to the mannose-6-phosphonate receptors of certain cancer cells and to the lipid bilayer of vesicles, thereby serving as a multivalent adhesive between cell and vesicle surfaces.
Toward reproducible, scalable, and robust data analysis across multiplex tissue imaging platforms (2020)

Abstract The emergence of megascale single-cell multiplex tissue imaging (MTI) datasets necessitates reproducible, scalable, and robust tools for cell phenotyping and spatial analysis. We developed open-source, graphics processing unit (GPU)-accelerated tools for intensity normalization, phenotyping, and microenvironment characterization. We deploy the toolkit on a human breast cancer (BC) tissue microarray stained by cyclic immunofluorescence and benchmark our cell phenotypes against a published MTI dataset. Finally, we demonstrate an integrative analysis revealing BC subtype-specific features.
Management of Mirizzi syndrome by laparoscopic cholecystectomy and laparoscopic ultrasonography (1995)

Journal Article Management of Mirizzi syndrome by laparoscopic cholecystectomy and laparoscopic ultrasonography Get access W C S Meng, W C S Meng Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar S P Y Kwok, S P Y Kwok Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar S B Kelly, S B Kelly Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar W Y Lau, W Y Lau Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar A K C Li A K C Li Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Correspondence to: Professor A. K. C. Li, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 82, Issue 3, March 1995, Page 396, https://doi.org/10.1002/bjs.1800820338 Published: 07 December 2005 Article history Accepted: 22 July 1994 Published: 07 December 2005
Tris(dimethylamino)sulfonium Difluorotrimethylsilicate, a Mild Reagent for the Removal of Silicon Protecting Groups (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTris(dimethylamino)sulfonium Difluorotrimethylsilicate, a Mild Reagent for the Removal of Silicon Protecting GroupsKarl A. Scheidt, Hou Chen, Bruce C. Follows, Sherry R. Chemler, D. Scott Coffey, and William R. RoushView Author Information Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, and Department of Chemistry, Indiana University, Bloomington, Indiana 47405 Cite this: J. Org. Chem. 1998, 63, 19, 6436–6437Publication Date (Web):August 29, 1998Publication History Received24 June 1998Published online29 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/jo981215ihttps://doi.org/10.1021/jo981215irapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views4750Altmetric-Citations224LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Anions,Ethers,Organic compounds,Protective groups,Reagents Get e-Alerts
Inhibitors of Protein Farnesyltransferase as Novel Anticancer Agents (2002)

This paper describes recent progress in the design, synthesis and biological evaluation of inhibitors for the enzyme protein farnesyltransferase (PFTase). This enzyme plays a critical role in the post-translational modification of a range of different intracellular proteins. In particular, PFTase attaches a farnesyl group to the GTPase Ras whose oncogenically mutated form is found in over 30% of human cancers. As a result PFTase inhibitors have been developed as potential cancer therapeutic drugs either by rational design based on the structure of the CAAX carboxyl terminus of Ras or random screening of chemical libraries or natural products. Some of these inhibitors show remarkable inhibition potency against PFTase at subnanomolar concentrations and >1000-fold selectivity compared to the related enzyme geranylgeranyltransferase-I. Certain of these compounds are highly effective at blocking the growth of human tumors in animal models and are now undergoing clinical trials. However, several issues in the research remain unsolved, including the mechanism by which PFTase inhibitors suppress tumor growth. Although it has been established that PFTase inhibitors block prenylation of Ras in vitro, the results in wholecells and animal studies suggest the possibility that proteins other than Ras are affected.
Hybrid construction of a 10MHz DC-DC converter for distributed power systems (1988)

Thesis (Elec. E.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1989.
Phénomènes de dissipation dans les nanostructures (2006)

Le terme de nanotechnologie est un nom générique qui regroupe une multitude de disciplines et d’applications sans réelle cohérence ou connexion. Nous pouvons citer pêle-mêle la nanoélectronique, la spintronique, l’électronique moléculaire, les nanomatériaux, les nanocristaux photoniques, les nanopar
Elimination of Mycoplasma contamination in Chlamydia stocks as a result of in vivo passage or plaque isolation (2018)

We have described two methods of eliminating Mycoplasma contamination from Chlamydia laboratory stocks. We conclude that Mycoplasma species commonly contaminating chlamydial stocks do not survive passage in mice. Chlamydia may also be derived Mycoplasma-free by plaque assay.