gebhart/patrepeval huggingface dataset:
Data from <sup>89</sup>Zr-panitumumab Combined With <sup>18</sup>F-FDG PET Improves Detection and Staging of Head and Neck Squamous Cell Carcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Determine the safety and specificity of a tumor-targeted radiotracer (&lt;sup&gt;89&lt;/sup&gt;Zr-pan) in combination with &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT to improve diagnostic accuracy in head and neck squamous cell carcinoma (HNSCC).&lt;/p&gt;Experimental Design:&lt;p&gt;Adult patients with biopsy-proven HNSCC scheduled for standard-of-care surgery were enrolled in a clinical trial and underwent systemic administration of &lt;sup&gt;89&lt;/sup&gt;Zirconium-panitumumab and panitumumab-IRDye800 followed by preoperative &lt;sup&gt;89&lt;/sup&gt;Zr-pan PET/CT and intraoperative fluorescence imaging. The sensitivity, specificity, and AUC were evaluated.&lt;/p&gt;Results:&lt;p&gt;A total of fourteen patients were enrolled and completed the study. Four patients (28.5%) had areas of high &lt;sup&gt;18&lt;/sup&gt;F-FDG uptake outside the head and neck region with maximum standardized uptake values (SUV&lt;sub&gt;max&lt;/sub&gt;) greater than 2.0 that were not detected on &lt;sup&gt;89&lt;/sup&gt;Zr-pan PET/CT. These four patients with incidental findings underwent further workup and had no evidence of cancer on biopsy or clinical follow-up. Forty-eight lesions (primary tumor, LNs, incidental findings) with SUV&lt;sub&gt;max&lt;/sub&gt; ranging 2.0–23.6 were visualized on &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT; 34 lesions on &lt;sup&gt;89&lt;/sup&gt;Zr-pan PET/CT with SUV&lt;sub&gt;max&lt;/sub&gt; ranging 0.9–10.5. The combined ability of &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT and &lt;sup&gt;89&lt;/sup&gt;Zr-pan PET/CT to detect HNSCC in the whole body was improved with higher specificity of 96.3% [confidence interval (CI), 89.2%–100%] compared to &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT alone with specificity of 74.1% (CI, 74.1%–90.6%). One possibly related grade 1 adverse event of prolonged QTc (460 ms) was reported but resolved in follow-up.&lt;/p&gt;Conclusions:&lt;p&gt;&lt;sup&gt;89&lt;/sup&gt;Zr-pan PET/CT imaging is safe and may be valuable in discriminating incidental findings identified on &lt;sup&gt;18&lt;/sup&gt;F-FDG PET/CT from true positive lesions and in localizing metastatic LNs.&lt;/p&gt;&lt;/div&gt;
Differential Minor Groove Interactions between DNA Polymerase and Sugar Backbone of Primer and Template Strands (2002)

DNA polymerases are the key enzymes for DNA synthesis involved in DNA replication, recombination, and repair. These enzymes undergo manifold contacts with the primer-template-substrates reaching up to several nucleotide pairs beyond the catalytic centre. To evaluate these enzyme contacts with the DNA substrates we applied novel synthetic steric probes in functional studies. We found that through application of the these probes valuable insights into DNA polymerase function can be gained, which might be useful for the design of new DNA polymerase-based nucleotide variation detection strategies.
Evaluating Splitter Blade Designs to Avoid Impeller Failure in a High-Speed Unshrouded Centrifugal Compressor (2019)

Abstract This study investigates splitter blade failures experienced during testing of an unshrouded transonic centrifugal compressor. Specifically, when the impeller was deeply throttled using an upstream inlet guide vane to introduce significant pre-swirl, the splitter blades exhibited cracking near the root of the leading edge. The observed failures are of particular interest because the impeller does not exhibit a mode shape typical of this type of failure corresponding to either the upstream IGV or downstream diffuser vane count, nor the anticipated surge frequencies. Accordingly, modal analysis and CFD modeling were performed leading to an understanding of the failure mechanism, and a successful splitter blade cut-back solution was implemented. Specifically, excitation sources developed from a CFD model of the IGV and impeller were used in a blade flutter calculation, in order to determine the aerodynamic damping and unsteady loading on the blade. The CFD model indicates that shockwaves arise near the splitter leading edge for this off-design condition. Due to interactions with the high incidence/separated boundary layer, these shockwaves exhibit streamwise unsteadiness, thereby leading to the observed failure mechanisms. It was determined that by cutting back the splitter blade at the leading edge, the failure could be avoided while minimally affecting the overall stage performance.
Tsg101 is required for the NiV-C enhancement of budding and efficient release of live NiV. (2016)

&lt;p&gt;&lt;b&gt;(A)&lt;/b&gt; NiV-C was minimally truncated at its C-terminus as indicated, with all constructs retaining a C-terminal HA tag. &lt;b&gt;(B)&lt;/b&gt; Truncation of only 7 residues (159tr) from NiV-C results in loss of interaction with Tsg101. &lt;b&gt;(C)&lt;/b&gt; This truncation mutant no longer enhances NiV-M budding. Error bars represent standard deviations for 3 independent experiments. ns, not significant; ***, p&lt;0.001, one-way ANOVA followed by Bonferroni posttests. &lt;b&gt;(D)&lt;/b&gt; Schematic of strategy to insert a destabilization domain (DD) tag onto all endogenous copies of Tsg101, via CRISPR/Cas9-mediated homologous recombination (HR). Exon 1 of Tsg101 in the human genome is shown, with the start codon highlighted in orange. Light blue highlight represents sequence used in the homology arms in the donor constructs. Once integrated into the genome, antibiotic resistance is driven off of the endogenous promoter, with the P2A ribosomal skipping sequence allowing the DD-Tsg101 fusion product to be translated separately. Green arrows indicate position of genotyping primers used for Fig 6E. &lt;b&gt;(E)&lt;/b&gt; Genotyping PCR of the single cell-isolated DD-Tsg101 293T clone with complete knock-in (KI), using genome-specific primers (see Fig 6D, green arrows) flanking the homology arms used in the donor constructs. Asterisk represents a background product. The puromycin and blasticidin donors insert 1,182 and 981 bp, respectively, hence the doublet seen in the knock-in PCR product. &lt;b&gt;(F)&lt;/b&gt; Knock-in DD-Tsg101 cells (KI) were incubated with 10 uM trimethoprim (TMP) (+ TMP) or DMSO vehicle control (- TMP) for 24h, then collected for comparison with parental 293T cells (WT) by Western. The upward shift in molecular weight for DD-Tsg101 is due to the 18 kDa DD tag fusion. The relative expression of Tsg101 indicated below the blot was normalized to the COX IV loading control. &lt;b&gt;(G)&lt;/b&gt; DD-Tsg101 cells were incubated in 10 uM TMP or DMSO vehicle as described in Materials and Methods before transfection with NiV-M and with or without NiV-C as indicated. Destabilization of DD-Tsg101 by removal of TMP abrogates the NiV-C enhancement of NiV-M budding. Error bars represent standard deviations for 3 independent experiments. ns, not significant; **, p&lt;0.01, 2-tailed Student’s t-test. &lt;b&gt;(H)&lt;/b&gt; DD-Tsg101 cells in 10 uM TMP or DMSO vehicle were infected with wild-type NiV at MOI 2 or Rift Valley fever virus (RVFV) at MOI 0.2, and supernatant titers were determined at 24 hpi. Error bars represent standard deviations for 3 replicates. ns, not significant; *, p&lt;0.05, 2-tailed Student’s t-test. &lt;b&gt;(I)&lt;/b&gt; DD-Tsg101 cells in 10 uM TMP or DMSO vehicle were infected with wild-type NiV at MOI 2 and processed for TEM as described in Materials and Methods. All fields are shown at the same magnification. &lt;i&gt;Right panels&lt;/i&gt;, samples were stained with anti-NiV-N and 15 nm colloidal gold. White arrows show examples of immunogold staining.&lt;/p&gt;
Geometric versus Texture Detail in 3-D Models of Real World Buildings (1995)

The creation of three-dimensional CAD models of real world objects and their rendering using photorealistic texture are current topics of investigation. In the case of buildings and other objects of urban environments the need for this technology is evident from various applications. The primary source material consists of images which serve for both the reconstruction of the object’s geometry and the creation of texture. Depending on the scale of the digital source images and on the specifics of an application one may require more or less detail of the geometry. The use of photorealistic texture enhances the perceived detail even in the absence of a detailed geometric model; however one needs to overcome correspondence problems between texture and geometry, which partly may be caused by issues of illumination. We present in this paper a progress report on one aspect of urban models, namely the reconstruction of roofs. To improve the automation of datacollection we propose the fusion of digital map data and aerial images. We discuss an affine matching procedure. In addition we illustrate the correspondence problem between geometry and photo-texture. Our initial experiences are based on results from two test sites, one in Vienna and the other in the city of Graz.
PLDI 2004 (2015)

Dynamic memory allocators (malloc/free) rely on mutual exclusion locks for protecting the consistency of their shared data structures under multithreading. The use of locking has many disadvantages with respect to performance, availability, robustness, and programming flexibility. A lock-free memory allocator guarantees progress regardless of whether some threads are delayed or even killed and regardless of scheduling policies. This paper presents a completely lockfree memory allocator. It uses only widely-available operating system support and hardware atomic instructions. It offers guaranteed availability even under arbitrary thread termination and crash-failure, and it is immune to deadlock regardless of scheduling policies, and hence it can be used even in interrupt handlers and real-time applications without requiring special scheduler support. Also, by leveraging some high-level structures from Hoard, our allocator is highly scalable, limits space blowup to a constant factor, and is capable of avoiding false sharing. In addition, our allocator allows finer concurrency and much lower latency than Hoard. We use PowerPC shared memory multiprocessor systems to compare the performance of our allocator with the default AIX 5.1 libc malloc, and two widely-used multithread allocators, Hoard and Ptmalloc. Our allocator outperforms the other allocators in virtually all cases and often by substantial margins, under various levels of parallelism and allocation patterns. Furthermore, our allocator also offers the lowest contention-free latency among the allocators by significant margins
Exploiting Geographical Context in D2D Communications (2016)

In this paper, we present a framework for including geographical context information within the process of relay selection, where both the relay and destination can be user equipment (UE) hence enabling relaying via device-to-device (D2D) communication. Geographical information, acquired through positioning systems and radio maps, are used to infer pathloss, link budgets and relay generated interference. Thus, this information becomes available at the core network without the aid of extra signaling and channel sounding. Tools from image processing can be exploited to analyze the radio map and determine so called isolated regions. Then, these regions are used by the proposed framework to effectively select the relay. Three different relay selection policies that exploit geographical context via the knowledge of the spatial isolated regions are introduced. Each of these policies is analyzed via simulation and performance is compared with respect to baseline schemes. The pertinence of adopting geographical information is confirmed by the gain in terms of useful power and reduced interference level generated.
[Fluorescence methods for studying cell damage]. (1998)

We have been studying some properties of the new generation photosensitizers--phthalocyanines. The influence of the certain phthalocyanine concentrations at combination with laser irradiation doses (semiconductor laser, lambda = 670 nm, P = 50 mW) have been studied by in vitro fluorescent methods. Cytotoxicity assay LIVE/DEAD for fluorescence microscopy and measurements of cells viability with multi-well plate scanner was used. The optimal phototoxic effect on MCF7--mamma carcinoma cells was observed 8 micrograms/ml ZnPcS2, 10 micrograms/ml ClAlPcS2 in combination with laser irradiation 50 J/cm2 and 100 J/cm2 respectively. This concentration and dose killed MCF7 carcinoma cells.
Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder (2005)

Attention deficit hyperactivity disorder (ADHD) is a complex condition, thought to have multiple subtypes lurking within a broad, behaviorally defined phenotype, making it difficult to identify specific biological causes of this syndrome. However, the evidence from studies conducted over the past decade suggests that dopamine (DA) plays a prominent role in the etiology and treatment of ADHD. Here we will start with consensus views that have emerged about ADHD at the behavioral, biological, and genetic levels of analysis. Then, we will summarize the evidence that links DA to ADHD.
Ground-Truth Transcriptions of Real Music from Force-Aligned MIDI Syntheses (2003)

Many modern polyphonic music transcription algorithms are presented in a statistical pattern recognition framework. But without a large corpus of real-world music transcribed at the note level, these algorithms are unable to take advantage of supervised learning methods and also have difficulty reporting a quantitative metric of their performance, such as a Note Error Rate. We attempt to remedy this situation by taking advantage of publicly-available MIDI transcriptions. By force-aligning synthesized audio generated from a MIDI transcription with the raw audio of the song it represents we can correlate note events within the MIDI data with the precise time in the raw audio where that note is likely to be expressed. Having these alignments will support the creation of a polyphonic transcription system based on labeled segments of produced music. But because the MIDI transcriptions we find are of variable quality, an integral step in the process is automatically evaluating the integrity of the alignment before using the transcription as part of any training set of labeled examples. Comparing a library of 40 published songs to freely available MIDI files, we were able to align 31 (78%). We are building a collection of over 500 MIDI transcriptions matching songs in our commercial music collection, for a potential total of 35 hours of note-level transcriptions, or some 1.5 million note events.
Variability aware modeling of SEU induced failure probability of logic circuit paths in static conditions (2015)

Voltage noise can lead to various errors such as dynamic and permanent, which are directly associated to circuit-level reliability issues. Variability in process parameters directly affects the probability of failures associated to voltage noise. Yet, the evaluation of the probability of failures by SPICE level Monte Carlo simulation is prohibitively time-consuming. This work proposes a technique to characterize the input noise and process variations in order to estimate failure probability in a logic circuit path composed of combinational cells and registers. The method allows to correctly estimate the order of magnitude of the probability of failures and to evidence the influence of process variations, while reaching >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> speedup versus SPICE.
Resonance affected scattering: Comparison of two hybrid methods involving filter diagonalization and the Lanczos method (1998)

We apply two hybrid methods for solving scattering problems affected by resonances, to a four-dimensional reactive surface scattering system. In each method the solution of the problem is divided into two parts: a wave packet propagation, and a resonance calculation; results of the resonance calculation are used to extrapolate the long-time behavior of the system. In the first hybrid method, the propagation is by the multistep Chebyshev method, with calculation of resonances performed by the Lanczos method. In the second, the propagation is done using an implementation of the absorbing boundary condition (ABC) evolution operator, and the resonance calculation by filter diagonalization (FDG). Each method produces accurate scattering results in much less computation time than standard long-time wave packet propagation. The Chebyshev–Lanczos approach proves most capable for the calculation of resonances, but is computationally expensive. The ABC–FDG method is much cheaper to implement, but could not be made to extract accurate data for certain broad, overlapping resonances. This was overcome by propagating longer (still much shorter than for long-time propagation) to allow the elusive resonances time to decay.
The Metabolic Clearance of Insulin and the Feedback Inhibition of Insulin Secretion Are Altered with Aging (1985)

Elevated basal and stimulated insulin levels have been previously demonstrated in elderly human subjects. To see whether these elevated insulin levels are due to alterations in either the metabolic clearance rate (MCR) for insulin or the feedback inhibition of insulin secretion, we have studied 14 elderly and 19 nonelderly subjects, mean age 70 +/- 2 and 35 +/- 2 yr, respectively. Fasting serum insulin and C-peptide levels were elevated in the elderly compared with the nonelderly, 17 +/- 2 versus 11 +/- 1 microU/ml, P less than 0.01 and 0.95 +/- 0.12 versus 0.47 +/- 0.07 pmol/ml, P less than 0.001. Euglycemic hyperinsulinemia created by insulin infusion rates of 15, 40, and 1200 mU/m2/min with glucose held constant resulted in steady-state serum insulin levels of 65 +/- 4, 109 +/- 8, and 11,316 +/- 890 versus 34 +/- 2, 96 +/- 5, and 11,083 +/- 1079 microU/ml in the elderly and nonelderly subjects, respectively. The MCR of insulin was decreased by 46% in the elderly compared with the nonelderly (10.1 +/- 0.7 versus 18.7 +/- 1.4 ml/kg/min) at the insulin infusion rate of 15 mU/m2/min with no difference observed between the two groups at the higher insulin infusions. Steady-state suppression of C-peptide by exogenous insulin was similar, 73 +/- 2% versus 72 +/- 2% and 70 +/- 3% versus 64 +/- 5% in the nonelderly and elderly groups during the 15 and 40 mU/m2/min insulin infusions, respectively. However, 50% suppression was achieved within 30 min in the nonelderly group compared with 70 min in the elderly group during the low-dose infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
Endoscopic management of the intrauterine septum (1990)

During 20 months of study 29 patients in whom congenital uterine anomalies were previously diagnosed by hysterosalpingography, had a combined hysteroscopy/laparoscopy procedure. In 17 cases, an intrauterine septum was cut under vision using CO2 hysteroscopy and/or optical scissors. No electrocautery or vasoconstrictor agents were needed to minimize the possibility of bleeding as the septum is of fibrous nature. No estrogen therapy was given and no IUDs were inserted post operatively. A second look hysteroscopy done 2 months later showed no intrauterine adhesions. Laparoscopic monitoring during the hysteroscopic procedure allowed avoidance of uterine perforation, assessment of the condition of the tubes and the ovaries as well as differentiation between bicornuate and septate uterus.
A Hybrid Positioning System for Location-Based Services: Design and Implementation (2020)

In this article, we propose a hybrid positioning system (HPS) for various seamless localization applications. The base stations in the HPS incorporate four wireless protocols, namely, WiFi, Bluetooth, ZigBee, and utral-wideband (UWB); as a result, the HPS shows better target detection because it can localize persons/ objects with different positioning devices (e.g., smartphone, UWB tag, Bluetooth tag) simultaneously. Moreover, it also exhibits good environmental adaptability because it can be deployed in different environments. We first present the system architecture of our HPS and then delve into the main hardware constituents. We detail the functions of each protocol for efficient positioning. The main motivation behind the design of our HPS is to realize a robust and precise indoor and outdoor seamless positioning system that is universally deployable from small to large-scale environments. Our HPS can effectively compensate for the shortcomings of existing standalone positioning systems and provide sufficient space for information fusion to yield more accurate positioning. Experimental results in a typical office environment have demonstrated the superiority of our proposed HPS in comparison with different fusion strategies. Two case studies are included to validate the powerful functions for providing personalized location- based services.
Ultrasensitive Calorimetric Measurements of the Electronic Heat Capacity of Graphene (2021)

Heat capacity is an invaluable quantity in condensed matter physics and yet has been completely inaccessible in two-dimensional (2D) van der Waals (vdW) materials, owing to their ultrafast thermal relaxation times and the lack of suitable nanoscale thermometers. Here, we demonstrate a novel thermal relaxation calorimetry scheme that allows the first measurements of the electronic heat capacity of graphene. It is enabled by combining a radio frequency Johnson noise thermometer, which can measure the electronic temperature with a sensitivity of ∼20 mK/Hz<sup>1/2</sup>, and a photomixed optical heater that modulates <i>T</i><sub>e</sub> with a frequency of up to Ω = 0.2 THz. This allows record sensitive measurements of the electronic heat capacity <i>C</i><sub>e</sub> < 10 <sup>-19</sup> J/K and the fastest measurement of electronic thermal relaxation time <i>τ</i><sub>e</sub> < 10 <sup>-12</sup> s yet achieved by a calorimeter. These features advance heat capacity metrology into the realm of nanoscale and low-dimensional systems and provide an avenue for the investigation of their thermodynamic quantities.
The Mastocytosis Society Survey on Mast Cell Disorders: Part 2—Patient Clinical Experiences and Beyond (2018)

These patient survey results are provided to assist medical professionals in learning patients' perceptions of their experiences and to give patients with mast cell disorders and caregivers the opportunity to compare experiences with those of other affected individuals.
(E,E)‐5‐Amino‐2,4‐pentadienal: Erstmalige präparative Herstellung des hydrolysierten Pyridins (1981)

Das Hauptprodukt der Photohydrolyse von Pyridin , die Titelverbindung (1a) , war bisher nur spektroskopisch charakterisiert worden. Die Herstellung im präparativen Maßstab [Nebenkomponente: (1b) ] gelang durch Reaktion von (2) mit Isopropylamin. magnified image