gebhart/patrepeval huggingface dataset:
Advancing in-memory Arithmetic Based on CMOS-integrable Memristive Crossbar Structures (2021)

Memristive computing will be advantageous in large-scale, highly parallel mixed-mode processing architectures because processing can be performed directly within memristive memory architectures and intrachip communication can be implemented by a memristive crossbar structure with reconfigurable logic gates. Here we report on the development of a new concept for in-memory adders, using XOR functionality. Exploited memristive crossbar structures are based on memristive complementary resistive switches, e.g. TaOx, and BiFeO3.
Chlorotris (η 5 ‐Cyclopentadienyl) Complexes of Uranium(IV) and Thorium(IV) (1990)

This chapter contains sections titled: Chlorotris(η5-cyclopentadienyl)uranium(IV) Chlorotris(η5-cyclopentadienyl)thorium(IV)
Multiprocessor silicon photonic interconnects: a systems perspective (2012)

The high bandwidth density and low power consumption characteristics of silicon photonics devices can provide a high performance interconnect solution for multiprocessor systems. At the same time this technology also poses a new set of constraints and challenges in architecting, designing, and integrating such systems. The "macrochip" multiprocessor architecture leverages a photonically interconnected array of processor and/or memory chips to provide a flexible platform to build heterogeneous systems. The design considerations for such a system are influenced largely by the system architecture, the programming model and devices needed for their implementation. This talk will first describe the macrochip platform, technology constraints and potential interconnect solutions with the various device building blocks. Then it will present some topology choices that range from a WDM point-to-point interconnect to more complex switched data channel networks. It will close with a detailed analysis of these design choices and show the impact of the device constraints on performance and power consumption along with some recent ultra-low power device implementation results.
ChemInform Abstract: Synthesis of 1,4‐Diaminocyclitols from L‐Serine Methyl Ester. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On-Chip Si3N4 Spatial Heterodyne Fourier Transform Spectrometer for the Optical Window in Biological Tissue (2021)

We designed and demonstrated an on-chip Fourier transform spectrometer on Si 3 N 4 -on-SiO 2 using an array of Mach-Zehnder interferometers (MZIs) for = 600~1000 nm. The retrieval of an input spectrum is demonstrated by the interconnect simulation.
Phylogenetic Tree Construction and “Truncal Loss” Analysis Reveal Hidden Associations Between Loss of Protein Expression in SWI/SNF Complex Components and Tumor Stage and Survival in Clear Cell Renal Cell Carcinoma (CCRCC) (2015)

BETWEEN LOSS OF PROTEIN EXPRESSION IN SWI/SNF COMPLEX COMPONENTS AND TUMOR STAGE AND SURVIVAL IN CLEAR CELL RENAL CELL CARCINOMA (CCRCC) Wei Jiang1, Essel Dulaimi2, Theodore Parsons1, Karthik Devarajan2, Qiong Wang1, Raymond O'Neill1, Charalambos C. Solomides1, Stephen C. Peiper1, Robert Uzzo2, Joseph R. Testa2, and Haifeng Yang1 1Thomas Jefferson University, Philadelphia, PA, United States; 2Fox Chase Cancer Center/Temple University, Philadelphia, PA, United States
Total Knee Arthroplasty After High Tibial Osteotomy Results in Excellent Long-Term Survivorship and Clinical Outcomes (2019)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
2P149 A novel supramolecular assembly and intermolecular electrontransfer process of Hyphomicrobium Cu-containing nitrite reductase(33. Redox enzyme,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006)

Thc dissimilatory Cu-containing nitrite reductase {NIR) receives one electron ut the type 1 Cu 'i'om an electron donor pi'otein, transfei's it to the type 2 Cu, and catalyzcs onc clectron reduction nf N02to NO at the site [11. We have recentiy succeeded in analyzing the X-ray crysta1 structure of MR <HdNIR) 1'rom a meLh},luLrephie denitrifing baeterium, Hyphoinicrobium dcnitrrfjcans A3151 {Fig,
Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing (2021)

T-type calcium channels are important regulators of neuronal excitability. The mammalian brain expresses three T-type channel isoforms (Cav3.1, Cav3.2 and Cav3.3) with distinct biophysical properties that are critically regulated by temperature. Here, we test the effects of how temperature affects spike output in a reduced firing neuron model expressing specific Cav3 channel isoforms. The modeling data revealed only a minimal effect on baseline spontaneous firing near rest, but a dramatic increase in rebound burst discharge frequency for Cav3.1 compared to Cav3.2 or Cav3.3 due to differences in window current or activation/recovery time constants. The reduced response by Cav3.2 could optimize its activity where it is expressed in peripheral tissues more subject to temperature variations than Cav3.1 or Cav3.3 channels expressed prominently in the brain. These tests thus reveal that aspects of neuronal firing behavior are critically dependent on both temperature and T-type calcium channel subtype.
Injecting position dependent currents in order to reduce oscillations caused by the gearbox of a dc-motor drive (2007)

An electrical drive consisting of a pwm-fed, digital-signal-processor controlled dc-motor, of a gearbox and the load is investigated. The gearbox features a high gear transmission ratio and converts the rotation of the dc-motor into a vertical translatory movement. Due to construction insufficiencies the gearbox causes torque disturbances, which influence the vertical acceleration. The underlying idea is to compensate the torque disturbances by position dependent control of the armature current. The appropriate phases and amplitudes of the currents are calculated using the signal derived from an acceleration sensor and the extrapolated angular rotor position information. Experimental results clearly show that it is possible to reduce the oscillations by improving the control algorithm of the drive. The mechanical system acts in a sufficiently linear manner; the dc-machine's nonlinearity due to slotting has only a minor effect.
Cilk: efficient multithreaded computing (1998)

This thesis describes Cilk, a parallel multithreaded language for programming contemporary shared memory multiprocessors (SMP&amp;apos;s). Cilk is a simple extension of C which provides constructs for parallel control and synchronization. Cilk imposes very low overheads --- the typical cost of spawning a parallel thread is only between 2 and 6 times the cost of a C function call on a variety of contemporary machines. Many Cilk programs run on one processor with virtually no degradation compared to equivalent C programs. We present the &amp;quot;work-first&amp;quot; principle which guided the design of Cilk&amp;apos;s scheduler and two consequences of this principle, a novel &amp;quot;two-clone&amp;quot; compilation strategy and a Dijkstra-like mutual-exclusion protocol for implementing the ready queue in the work-stealing scheduler. To facilitate debugging of Cilk programs, Cilk provides a tool called the Nondeterminator -2 which finds nondeterministic bugs called &amp;quot;data races&amp;quot;. We present two algorithms, All-Sets and Brelly, used by the N...
Endogenous Circulating Sympatholytic Factor in Orthostatic Intolerance (2000)

Sympathotonic orthostatic hypotension (SOH) is an idiopathic syndrome characterized by tachycardia, hypotension, elevated plasma norepinephrine, and symptoms of orthostatic intolerance provoked by assumption of an upright posture. We studied a woman with severe progressive SOH with blood pressure unresponsive to the pressor effects of alpha(1)-adrenergic receptor (AR) agonists. We tested the hypothesis that a circulating factor in this patient interferes with vascular adrenergic neurotransmission. Preincubation of porcine pulmonary artery vessel rings with patient plasma produced a dose-dependent inhibition of vasoconstriction to phenylephrine in vitro, abolished vasoconstriction to direct electrical stimulation, and had no effect on nonadrenergic vasoconstrictive stimuli (endothelin-1), PGF-2alpha (or KCl). Preincubation of vessels with control plasma was devoid of these effects. SOH plasma inhibited the binding of an alpha(1)-selective antagonist radioligand ([(125)I]HEAT) to membrane fractions derived from porcine pulmonary artery vessel rings, rat liver, and cell lines selectively overexpressing human ARs of the alpha(1B) subtype but not other AR subtypes (alpha(1A) and alpha(1D)). We conclude that a factor in SOH plasma can selectively and irreversibly inhibit adrenergic ligand binding to alpha(1B) ARs. We propose that this factor contributes to a novel pathogenesis for SOH in this patient. This patient's syndrome represents a new disease entity, and her plasma may provide a unique tool for probing the selective functions of alpha(1)-ARs.
Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics (2020)

Abstract Achieving precision oncology requires accurate identification of targetable cancer vulnerabilities in patients. Generally, genomic features are regarded as the state-of-the-art method for stratifying patients for targeted therapies. In this work, we conduct the first rigorous comparison of DNA- and expression-based predictive models for viability across five datasets encompassing chemical and genetic perturbations. We find that expression consistently outperforms DNA for predicting vulnerabilities, including many currently stratified by canonical DNA markers. Contrary to their perception in the literature, the most accurate expression-based models depend on few features and are amenable to biological interpretation. This work points to the importance of exploring more comprehensive expression profiling in clinical settings.
Immunomodulation as Therapy for Fungal Infection: Are We Closer? (2018)

Invasive fungal disease (IFD) causes significant morbidity in immunocompromised patients due to their weakened immune system. Immunomodulatory therapy, in synergy with existing antifungal therapy, is an attractive option to enhance their immune system and aid clearance of these opportunistic pathogens. From a scientific and clinical perspective, we explore the immunotherapeutic options to augment standard antifungal drugs for patients with an IFD. We discuss the range of immunomodulatory therapies being considered in IFD - from cytokines, including G-CSF, GM-CSF, M-CSF, IFN-γ, and cytokine agonists, to cellular therapies, consisting of granulocyte transfusion, adoptive T-cell, CAR T-cell, natural killer cell therapies, and monoclonal antibodies. Adjunct pharmaceutical agents which augment the immunity are also being considered. Lastly, we explore the likelihood of the use of probiotics and manipulation of the microbiome/mycobiome to enhance IFD treatment outcomes.
Distributed Measurement of the Shape of Microbends in Optical Fibers (2021)

We present the distributed shape measurement of microbends in a twisted multicore optical fiber. The measurement resolution of the fiber shape reconstruction is ~40 µm in the longitudinal domain and sub-micron in the transverse domain.
Interactions in planar metamaterials and their use for active tuning. (2011)

Abstract not provided.
P52. A new pathway of tumour antigen loading of human dendritic cells via intercellular communication (2014)

Meeting abstracts Most cancer cells down-regulate gap junctions (GJ) resulting in loss of communication with their surrounding microenvironment. We have previously shown that infection of mouse tumour cell lines with Salmonella induces the up-regulation of connexin 43 (Cx43), a ubiquitous protein
Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations (2017)

Diffuse large B cell lymphoma (DLBCL) frequently harbors genetic alterations that activate the B cell receptor (BCR) and TLR pathways, which converge to activate NF-κB. While selective inhibition of BTK with ibrutinib causes clinical responses in relapsed DLBCL patients, most responses are partial and of a short duration. Here, we demonstrated that MyD88 silencing enhanced ibrutinib efficacy in DLBCL cells harboring MyD88 L265P mutations. Chemical downregulation of MyD88 expression with HDAC inhibitors also synergized with ibrutinib. We demonstrate that HDAC inhibitor regulation of MyD88 expression is mediated by STAT3. In turn, STAT3 silencing caused a decrease in MyD88 mRNA and protein levels, and enhanced the ibrutinib antilymphoma effect in MyD88 mutant DLBCL cells. Induced mutations in the STAT3 binding site in the MyD88 promotor region was associated with a decrease in MyD88 transcriptional activity. We also demonstrate that treatment with the HDAC inhibitor panobinostat decreased phosphorylated STAT3 binding to the MyD88 promotor. Accordingly, combined treatment with panobinostat and ibrutinib resulted in enhanced inhibition of NF-κB activity and caused regression of DLBCL xenografts. Our data provide a mechanistic rationale for combining HDAC inhibitors and ibrutinib for the treatment of DLBCL.
Technical accuracy of for scanned particle therapy of intra (2009)

An integrated 3-dimensional beam t tem was developed to adapt scanned ion beams targets and tested in terms of its speed and acc system response time was deduced to be ~ 1 m beam tracking and 16±2 ms for a longitudinal shif water equivalence. Accuracy of the lateral beam t measured with a multi-wire position detector to standard d
ChemInform Abstract: Synthesis and Utility of Dihydropyridine Boronic Esters. (2016)

Abstract When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester.
Impact of Mixing Ratio and Placement of SMF and Large Aeff PSCF on 448 Gb/s 2SC-DP-16QAM Transmission (2012)

We experimentally investigate transmission performance of 448 Gb/s two sub-carrier DP-16QAM over mixed large-Aeff pure silica core fibre and standard SMF link and demonstrate performance dependency on fibre connection order as well as mixing ratio.
Connected Factory (2020)

This chapter first discusses the capabilities of 5G as defined in Release 15 that can be used for the manufacturing industry and describes the use cases needed for the manufacturing industry. The illustrated use cases can be roughly classified into five major characteristics: factory automation, processes automation, human–machine interfaces and production IT, logistics and warehousing, as well as monitoring and maintenance. It should be clear that a particular use case may have one or more of the characteristics. The chapter discusses each in order. In Release 16, 3GPP will start to close the gaps from the information and communication technology 5G to that needed by the smart factory. As 3GPP completes its work, it can be readily seen that all aspects of the untethered communication can be met by new 3GPP releases and will make 5G a key enabler for redefining the manufacturing process.
1.2-kW all-fiber Yb-doped multicore fiber amplifier (2023)

We have demonstrated a record-high 1.2 kW, all-fiber multicore amplifier using a six-core single-mode Yb-doped fiber and a multicore pump-signal combiner (PSC). The output power is limited by the pump power of 1.9 kW. We have developed double-clad six-core fibers and PSCs for this demonstration. Each of the six Yb-doped cores has a 17-µm mode-field diameter (MFD) with a trench index profile and is capable of kW-class operation. The potential power scaling to the 10-kW level in a single amplifier with high brightness should be feasible with advanced thermal management and coherent beam combination.
Synthesis of functional chelating diphosphines containing the bis[2-(diphenylphosphino)ethyl]amino moiety and the use of these materials in the preparation of water-soluble diphosphine complexes of transition metals (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of functional chelating diphosphines containing the bis[2-(diphenylphosphino)ethyl]amino moiety and the use of these materials in the preparation of water-soluble diphosphine complexes of transition metalsRalph G. Nuzzo, Sharon L. Haynie, Michael E. Wilson, and George M. WhitesidesCite this: J. Org. Chem. 1981, 46, 14, 2861–2867Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/jo00327a005https://doi.org/10.1021/jo00327a005research-articleACS PublicationsRequest reuse permissionsArticle Views1602Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Social Memory (2023)

Abstract This article highlights the significance of social memory in Christian missions. Memory is a crucial phenomenon that shapes how individuals perceive reality and make decisions. Social memory, in particular, can aid anthropological researchers and Christian missionaries in engaging with people groups. The article summarizes the history of social memory studies and explores the effects of social trauma on group memory. It emphasizes the importance of understanding the context of a target people’s past for the success of the Christian mission. By examining a social group’s history, missionaries can gain insights into how the group is likely to respond to the Gospel message and how they are likely to interpret and apply it in their lives. Overall, comprehending the context is essential for the success of the Christian mission.
Multi-GHz Monolithic Voltage-Controlled Oscillators In Advanced Silicon Bipolar Technology (2005)

Relaxation-type Monolithic Silicon Bipolar Voltage-controlled Oscillators (VCOs) With Center Frequencies Ranging From 1.5 To 5 GHz Are Described. The Maximum Oscillating Frequency Achieved Is 7.4 Ghz. The VCOs Dissipate About 70 mW From a 3.6 V Supply, Including The Output Buffer And Voltage-to-current Converter Stages. Two Types Of On-chip Timing Capacitor Structures And Various Configurations Used In Achieving These Results Are Described. A Wide Tuning Range Has Been Achieved Which Is Sufficient To Cover The Normal Process Tolerances And Supply Variations Expected In A Practical Environment. The Circuits Are Fabricated In An Advanced 0.8 /spl mu/m Double-poly Self-aligned Bipolar Technology.
Adaptive linear turbo equalization of large delay spread time-varying channel responses (2010)

In this paper, we investigate applying linear turbo equalization techniques to underwater acoustic communications. First, we elaborate on two popular linear turbo equalizers (TEQ), a channel estimate-based minimum mean square error TEQ (CE-based MMSE-TEQ) and a direct-adaptive TEQ (DA-TEQ). We compare the behavior of both TEQ approaches in the presence of channel estimation errors and adaptation filter adjustment errors. By analyzing extrinsic information transfer (EXIT) charts, we confirm that the performance gap between these two TEQs is small after convergence. Next, we introduce an underwater receiver architecture based on the LMS DA-TEQ technique that dramatically improves the performance of the conventional decision-feedback equalizer at a feasible complexity. This receiver architecture is demonstrated using data collected from the SPACE 08 experiment. The experimental results demonstrate that the LMS DA-TEQ yields more than an order of magnitude performance gain over the conventional equalizer.
[Speciation and vertical distribution of heavy metals in sediments of Baiyangdian Lake]. (2012)

In order to find out the heavy metal concentrations and their potential ecological risks on sediments in Baiyangdian Lake, 0-14 cm surface sediments had been collected by the no-disturbance-gravity sampler at seven representative sampling points of Baiyangdian Lake. Optimized BCR sequential extraction procedure was used to carry out the analysis of heavy metal forms in the surface sediments. The heavy metal contents of different forms and in different depths were determined. The relationship between different forms of heavy metal and total organic carbon (TOC) in the sediments was analyzed. The geo-accumulation index (Igeo) was employed to evaluate the extent of heavy metal contamination. The results demonstrated that Co, Fe, Mn, Pb, Zn were mainly in residual form, acid soluble form, Fe-Mn oxide and organic matter bound forms respectively. The tendency of organic bound form of heavy metals and TOC of sediments was greater than the others. The concentration of Co, Pb, Zn decreased with the increase of sediment depth, with the maximal concentration was between 0-2 cm, while the concentration of Mn was the minimal between 6-8 cm and the maximal was at 14 cm. Baiyangdian sediments were not contaminated as a whole by Co, Mn, apart from medium pollution in the entrance of the Fuhe River. The other regions were lightly polluted by Zn and Pb.
Correction: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation (2016)

Nature Communications 7: Article number:11022 (2016); Published 19 April 2016; Updated 14 June 2016 In the original version of this Article, the middle names or initials of the authors Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J.E. Kelder, Sarah L. Parylak, Apuã C.M. Paquola and Jennifer A. Erwin were omitted from the author information.
Structure-based design, synthesis and pharmacological characterization of estrogen receptor isotype selective ligands (2004)

Estrogen receptor beta (ERbeta) was detected as a second nuclear estrogen receptor in 1996. The two estrogen receptor (ER) isotypes exhibit both, differential and overlapping, tissue distribution. While information on the physiological role of each ER isotype is accumulating due to knock out animal experiments (loss of function), proof of biological functions using selective ligands is limited.