gebhart/patrepeval huggingface dataset:
Logistic regression model training based on the approximate homomorphic encryption (2018)

Abstract Background Security concerns have been raised since big data became a prominent tool in data analysis. For instance, many machine learning algorithms aim to generate prediction models using training data which contain sensitive information about individuals. Cryptography community is considering secure computation as a solution for privacy protection. In particular, practical requirements have triggered research on the efficiency of cryptographic primitives. Methods This paper presents a method to train a logistic regression model without information leakage. We apply the homomorphic encryption scheme of Cheon et al. (ASIACRYPT 2017) for an efficient arithmetic over real numbers, and devise a new encoding method to reduce storage of encrypted database. In addition, we adapt Nesterovâ s accelerated gradient method to reduce the number of iterations as well as the computational cost while maintaining the quality of an output classifier. Results Our method shows a state-of-the-art performance of homomorphic encryption system in a real-world application. The submission based on this work was selected as the best solution of Track 3 at iDASH privacy and security competition 2017. For example, it took about six minutes to obtain a logistic regression model given the dataset consisting of 1579 samples, each of which has 18 features with a binary outcome variable. Conclusions We present a practical solution for outsourcing analysis tools such as logistic regression analysis while preserving the data confidentiality.
High-sensitivity EUV Resists based on Tetrafluoroethylene contained Fluoropolymers (2011)

There is a growing interest in the fluorinization of resist materials in improving pattern formation efficiency for extreme ultraviolet (EUV) lithography. The increased polymer absorption coefficient obtained through this resist platform is expected to enhance acid production and in effect improve pattern formation efficiency. Our work over the past several years has shown that the main-chain fluorinated base resins realized by the co-polymerization of tetrafluoroethylene (TFE) and norbornene derivatives offer high dissolution rates. Based on this, a EUV resist which was prepared using the fluorinated polymers was investigated. Imaging evaluations, using the small field exposure tool (SFET by Canon / EUVA) with annular (σ outer 0.7 / σ inner 0.3) illumination conditions were performed. Relatively high sensitivity of 6.3mJ⋅cm-2 for half-pitch (hp) 45nm and satisfactory resolution limit of hp 40nm was achieved. At present, line width roughness (LWR) was measured at comparatively large values of more than 8.4nm at hp 45nm. This shows that further material and process optimizations may be necessary to improve its present lithographic capability. However, these initial results have shown the potential of fluorinated-polymer based platform as a possible solution for high sensitivity, high resolution and low LWR EUV resists. In this paper, we report recent results of high sensitivity of 5.1mJ?cm-2 for half-pitch (hp) 40nm, optimization of protecting groups and photo acid generators.
DEVELOPMENT OF A MODEL SYSTEM TO COMPARE CELL SEPARATION METHODS FOR THE ISOLATION OF FETAL CELLS FROM MATERNAL BLOOD (1996)

Three major methods have been described for the isolation of fetal cells from maternal blood: fluorescence-activated cell sorting (FACS), immunomagnetic beads, and magnetic-activated cell sorting (MACS). To date, no study has directly compared fetal cell recovery using each of these methods. Here we describe our system using a "model' male fetal cell mixed into female peripheral blood mononuclear cells. Fetal cell yields and purities were assayed by a quantitative polymerase chain reaction (qPCR) using chromosomes Y- and 7-specific sequences. Fetal cell recovery was investigated by selection of CD71+ cells or depletion of CD45+ cells. Our data demonstrated variation in fetal cell recovery for all methods tested, although CD71+ selection by FACS gave the best and most consistent results.
Microarray analysis of early and late passage chicken embryo fibroblast cells (2013)

Primary cultured cells derived from normal tissue have a limited lifespan due to replicative senescence and show distinct phenotypes such as irreversible cell cycle arrest and enlarged morphology. Studying senescence-associated genetic alterations in chicken cells will provide valuable knowledge of cellular growth characteristics, when compared with normal and rapidly growing cell lines. Microarray analysis of early- and late-passage (passage 4 and 18, respectively) primary chicken embryo fibroblast (CEF) cells was performed with a 4X44K chicken oligo microarray. A total of 1,888 differentially expressed genes were identified with a 2-fold level cutoff that included 272 upregulated and 1,616 downregulated genes in late-passage senescent CEF cells. Bioinformatic analyses were performed using Ingenuity Pathway Analysis (IPA, http://www.ingenuity.com). Of the 1,888 differentially expressed genes in senescent CEF cells, 458 were identified as functionally known genes and only 61 genes showed upregulation. Because senescent cells generally showed the deactivated states of most cellular mechanisms for proliferation and energy metabolism, intensified analysis on upregulated genes revealed that the molecular mechanisms in senescent CEF cells are characterized by the suppression of cell cycle and proliferation, progression of cell death including apoptosis, and increased expression of various secreting factors. These regulatory pathways may be opposite to those found in the immortal CEF cell line, such as the DF-1 immortal line. Further comparison of differentially expressed genes between senescent and immortal DF-1 CEF cells showed that 35 genes overlapped and were oppositely regulated. The global gene expression profiles may provide insight into the cellular mechanisms that regulate cellular senescence and immortalization of CEF cells.
In vitro inhibition of enamel demineralization by a polymerizable amphiphilic film (2000)

An amphiphilic coating is configured as a substantive film that has a tendency for an in-plane two-dimensional polymerization. This coating is hypothesized to protect enamel from in vitro acid decalcification, assessed through the following artificial caries model. Three regions on labial enamel of eight bovine incisors were treated with an acid resistant varnish (A), the amphiphilic coating (B), or left undisturbed (C), and the teeth were immersed for 3 wk in lactic acid gel. Mineral loss (deltaZ-value) was determined by a cross-sectional microhardness technique. deltaZ-values (mean +/- SD; volume percent mineral-microm) were: -4 +/- 24 (A), 29 +/- 69 (B), and 7,372 +/- 1,766 (C). deltaZ-value of the uncoated enamel (C) was significantly different from the other groups. Scanning electron microscopy showed enamel etched pattern from citric acid, and the coating firmly attached on enamel surface. This amphiphilic coating can inhibit enamel decalcification under the present experimental condition.
Fabrication of low-threshold voltage micro-lasers (1992)

The voltage required for threshold in vertical cavity surface emitting lasers (VCSELs) has been reduced to 1.7 V. Molecular beam epitaxy (MBE) was used to grow 30 pairs of n-doped AlGaAs/AlAs bottom mirrors and the active p-n junction with a 1- mu m p-doped top contact. Twelve pairs of alternating SiO/sub 2//Si/sub 3/N/sub 4/ layers formed a high-reflectivity mirror which was used to complete the laser cavity. It is shown that the combination of high-reflectivity dielectric mirror layers with accurate MBE growth can be used to significantly reduce the power requirements of individual laser elements. It is expected that this advance will allow one to integrate large numbers of VCSEL devices into complex arrays without the heat-dissipation problems found in more conventional VCSEL designs. Finally, the relatively shallow depth of the active area from the semiconductor surface allows one to greatly simplify the VCSEL fabrication process.
Combined hardware selection and pipelining in high-performance data-path design (1992)

At the highest abstraction level, the specification of a data path consists of a number of interconnected abstract building blocks and a constraint on the minimal clock frequency. An algorithm which optimally selects hardware blocks for implementing these abstract building blocks is presented. A technique for hierarchical redistribution and insertion of pipeline registers is also presented. Finally, the two optimization tasks are combined. This combination makes the area tradeoff between the cost of additional speedup circuitry and pipeline registers possible. The techniques are based on accurate hierarchical timing models for the hardware blocks. The automation relieves the designer of the numerous, time-consuming critical path verifications and area evaluations that are required to explore the large design space. The implementation of the algorithms has resulted in a CAD tool called HANDEL, embedded in the data-path compiler CHOPIN.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
<title>Optical limiting via nonlinear scattering with sol-gel host materials</title> (1999)

We describe studies of optical limiting by thermally induced nonlinear light scattering in highly porous solgel glasses. We impregnate the porous glass with a solution of reverse saturable absorber in a solvent that is index-matched to the solgel matrix at room temperature. We observe a strong enhancement of the limiting properties at high energies in the porous glass, compared to the performance of the reverse saturable absorber alone. We attribute this effect to nonlinear scattering. However, the properties of this scattering are substantially different to what was originally expected. We provide evidence that the observed effect is due to formation of gas bubbles in the focal region of the laser beam. These bubbles are trapped in the host matrix, allowing the effect to accumulate over several laser shots.
Demonstration of Codesign Workflow in PeaCE (1997)

A concurrent hardware software codesign environment, PeaCE, is presented in this paper. PeaCE provides the designer with an environment in which the designer can design hardware and software components in a concurrent and cooperative manner. PeaCE covers the codesign which consists of specification, algorithm validation, partition, cosimulation, synthesis, and testing on prototyping board. The codesign workflow shown in this paper is demonstrated with 16-QAM modulation example. 1 Introduction A concurrent engineering of system design, known as codesign, is an emerging technology in design automation field for reducing design cost and shortening turnaround time. To avoid problems of traditional design process, codesign concept has gained more and more attention among system designers[3, 7, 8, 9]. For concurrent and interactive design, the codesign system needs to provide the following capabilities: unified hardware/software representation, hardware /software partitioning, heterogeneous ...
An interpretable framework for investigating the neighborhood effect in POI recommendation (2021)

Geographical characteristics have been proven to be effective in improving the quality of point-of-interest (POI) recommendation. However, existing works on POI recommendation focus on cost (time or money) of travel for a user. An important geographical aspect that has not been studied adequately is the neighborhood effect, which captures a user's POI visiting behavior based on the user's preference not only to a POI, but also to the POI's neighborhood. To provide an interpretable framework to fully study the neighborhood effect, first, we develop different sets of insightful features, representing different aspects of neighborhood effect. We employ a Yelp data set to evaluate how different aspects of the neighborhood effect affect a user's POI visiting behavior. Second, we propose a deep learning-based recommendation framework that exploits the neighborhood effect. Experimental results show that our approach is more effective than two state-of-the-art matrix factorization-based POI recommendation techniques.
Broadband Telecommunications Technologies and Management (2016)

The focus of this book is broadband telecommunications: both fixed (DSL, fiber) and wireless (1G-4G). It uniquely covers the broadband telecom field from technological, business and policy angles. The reader learns about the necessary technologies to a certain depth in order to be able to evaluate and analyse competing technologies. The student can then apply the results of the technology analysis to business (revenues and costs, market size, etc) to evaluate how successful a technology may be in the market place. Technology and business analyses lead to policy analysis and how government deal with rolling out of broadband networks; content (such as text, audio and video) delivered over them. Furthermore, how government may ensure a competitive and fair environment is maintained for service provision. The book is unique in its approach as it prepares the student to evaluate products from three different viewpoints of technology-business and policy. The book provides a unified vision for broadband communications, offering the required background as well a description of existing broadband systems, finishing with a business scenario. The book breaks new ground by discussing telecommunication technologies in a business and policy context.
Cancer as a disease of DNA organization and dynamic cell structure. (1989)

Analyse de l'importance de la structure nucleaire et cellulaire de l'organisation de l'ADN, elements susceptibles d'etre alteres dans la cellule tumorale
Using Formation-Testing-While-Drilling Pressures to Optimize a Middle East Carbonate Reservoir Drilling Program (2009)

Abstract Formation-testing-while-drilling (FTWD) technology was introduced in 2002 and has been used primarily for applications similar to wireline formation testers (WFT). These applications include accurate formation pressures, gradient analysis, formation connectivity, differential depletion, and flow barrier detections. A largely untapped application for FTWD is drilling optimization. The testing practices for drilling optimization are somewhat different than those used for typical WFT applications. In these cases, it is desirable to obtain pressures as soon as possible; and real-time test results are paramount. Combined with other downhole drilling information, such as vibration, torque, and weight-on-bit, drilling parameters can be adjusted to improve the rate of penetration (ROP) and make adjustments to the wellbore stability model in real-time. This paper reviews a Middle East case study in a carbonate gas reservoir. In part of this field, the reservoir pressure was uncertain due to possible communication with a high-pressure lower interval. Therefore, establishing the actual formation pressure was a priority. By monitoring the FTWD pressure tests in real-time, it was possible to verify the quality and validity of each test. Then, the test data was used to change mud parameters gradually. A composite log clearly indicates how decreasing annular pressures resulted in an increase in ROP. The method of testing and real-time monitoring results are reviewed and compared with high-resolution memory data from the FTWD tool. Comparison validated the real-time test data. Conclusions are drawn concerning drilling applications and how such test data can be utilized to improve the drilling process.
Comparação da produção de conídios de isolados de Isaria javanica em arroz parboilizado. (2018)

Desta forma, o objetivo deste trabalho foi comparar a producao de conidios de tres isolados de I. javanica CG 1282; CG 1284; CG 1283, selecionados como os mais virulentos a ninfas de B. tabaci.
INFLUENCE OF GROWTH CONDITIONS AND OF ALLOY COMPOSITION ON ELECTRICAL AND OPTICAL PROPERTIES OF MBE AlxGa1-xAs (0.2 = x = 0.4) (1982)

2K photoluminescence (PL), Hall effect, admittance and DLTS measurements were used to study in detail the influence of growth conditions and of alloy composition on the electrical and optical properties of nominally undoped and of Si-doped n-AlxGa1-xAs (0.15 < x < 0.45) layers grown by molecular beam epitaxy (MBE). Over the entire range of alloy composition investigated, the observed PL intensity depends critically on the growth temperature. Superior minority carrier properties can be achieved only at substrate temperatures above 640°C and slightly As-stabilized (2x4) surface reconstruction. Alloy compositions close to the direct-indirect cross-over lead to a considerable broadening of the PL transitions. Simultaneously the energy separation between the acceptor associated and bound exciton transitions increases due to the deepening of the donor level. The admittance measurements directly yielded the binding energy of the shallow donor level and showed the existence of one dominant electron trap in MBE n-AlxGa1-xAs : Si. The trap concentration was found to increase considerably with enhanced Al content. In MBE n-AlxGa1-xAs : Si with x < 0.25, the trap concentration is below the detection limit of the admittance technique. Additional DLTS measurements demonstrate that the trap concentration in MBE grown alloy material is routinely on the order of 10-2 of the intentional doping concentration.
Response to Liu et al. (2020)

Letter to: Comments on the study comparing multiple stents and single stent insertion for chronic pancreatitisEndosc Int Open 2020; 08(04): E467-E468DOI: 10.1055/a-1118-3563
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity (2020)

Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection or limit disease progression. We showed previously that short-term broadly neutralizing antibody (bNAb) therapy given 24 h after oral exposure cleared simian-human immunodeficiency virus (SHIV) in a macaque model of perinatal infection. Here, we report that all infants given either a single dose of bNAbs at 30 h, or a 21-day triple-drug ART regimen at 48 h, are aviremic with almost no virus in tissues. In contrast, bNAb treatment beginning at 48 h leads to tight control without adaptive immune responses in half of animals. We conclude that both bNAbs and ART mediate effective post-exposure prophylaxis in infant macaques within 30-48 h of oral SHIV exposure. Our findings suggest that optimizing the treatment regimen may extend the window of opportunity for preventing perinatal HIV infection when treatment is delayed.
Tailoring Treatment to the Individual Patient: Drug Monitoring (2014)

Understanding why drug concentrations vary between patients and which drug concentrations are associated with efficacy allow the development of rational treatment algorithms. Factors that affect the clearance of monoclonal antibodies include: (1) the presence of antidrug antibodies (increased clearance), (2) concomitant immunosuppression (decreased clearance), (3) increased serum CRP concentration (increased clearance), (4) decreased serum albumin concentration (increased clearance), (5) decreased body weight (increased clearance), and (6) increased fecal infliximab concentration (increased clearance). These factors can result in marked variability in drug clearance. Higher serum infliximab and adalimumab concentrations are associated with increased rates of clinical response and mucosal healing, and lower rates of colectomy. Treatment algorithms incorporate the following principles: (1) patients who have symptoms of active disease and in whom high concentrations of antibodies to infliximab or adalimumab are present should switch to another TNF antagonist, (2) patients who have symptoms of active disease and in whom there are low concentrations of infliximab or adalimumab should have dose intensification, and (3) patients who are negative for antidrug antibody and who have a therapeutic drug concentration should undergo evaluation to confirm the presence of active disease by endoscopy or radiology studies, and if active disease is confirmed, then these patients should discontinue anti-TNF therapy and switch to another class of medications or consider surgical options.
PRKAR1A deficiency delays postnatal heart growth (2020)

Aims Protein kinase A (PKA) activity is pivotal for proper functioning of the human heart, and its dysregulation has been implicated in a variety of cardiac pathologies. PKA regulatory subunit 1α (R1α, encoded by the PRKAR1A gene) is highly expressed in the heart, and controls PKA kinase activity by sequestering the catalytic subunits. Patients with PRKAR1A mutations are often diagnosed with Carney complex (CNC) in young adults and may die prematurely from cardiac complications such as heart failure. However, no cardiac defect has been reported in adult animal models of PRKAR1A deficiency. Methods and Results To investigate the impact of PRKAR1A deficiency on the heart, we generated cardiac‐specific PRKAR1A heterozygous knockout ( cPRKAR1A +/− ) mice by breeding the floxed PRKAR1A mice with the Mlc2v‐Cre mice. We also studied a cohort of young CNC patients with PRKAR1A mutations or deletions. Ablation of the PRKAR1A gene in mice increased cardiac PKA activity, reduced heart weight to body weight ratio (Control: 5.3±0.19, c PRKAR1A +/− : 4.7±0.11 mg/g, P&lt;0.05 ) and cardiomyocyte size (Control: 298.5±9.8 μm 2 , c PRKAR1A +/− : 191.3±4.5 μm 2 , P&lt;0.005 ) without altering contractile function at 3 months of age. Importantly, left ventricular mass was reduced in young patients diagnosed with CNC (Female control: 80.6 ± 12.8g, CNC: 70.8 ± 8.1, P&lt;0.05 ). Cardiomyocyte hypertrophy in response to activation of the α1‐adrenergic receptor, which is necessary for heart growth after birth, was completely abolished by silencing of PRKAR1A , or stimulation with the PKA activator forskolin. Mechanistically, depletion of PRKAR1A provoked PKA‐dependent phosphorylation of the mitochondrial fission protein Drp1 at S637, leading to suppression of mitochondrial fission and inhibition of cardiomyocyte hypertrophy. Conclusions Combined with previous findings that mitochondrial fission is required for hypertrophic growth of cardiomyocytes, our results suggest that PRKAR1A deficiency impedes postnatal myocardial development and physiological hypertrophy through modulation of mitochondrial dynamics. These findings provide a potential novel mechanism for the cardiac manifestations associated with CNC. Support or Funding Information This study was supported by intramural program of National Institute of Child Health and Human Development (NICHD), National Institutes of Health, National Heart, Lung, and Blood Institute (NIH R00HL119605, R56HL145034); WSU College of Pharmacy and Pharmaceutical Sciences.