gebhart/patrepeval huggingface dataset:
Binaural auralization of proposed room modifications based on measured omnidirectional room impulse responses (2017)

The auralization of rooms with dynamic binaural synthesis using binaural room impulse responses (BRIRs) is an established approach in virtual audio. The BRIRs can either be obtained by simulations or by measurements. Up to now changed acoustical properties, as they occur when a room is altered in a renovation, cannot easily be considered in a measurement-based approach. This paper presents a new method to auralize modifications of existing rooms. The authors already have shown in a previous publication that such an auralization can be done by appropriately shaping the reverberation tail of an impulse response. Furthermore, the authors have presented an approach to synthesize BRIRs based on one omnidirectional room impulse response (RIR). In this paper, both methods are combined: A single measured omnidirectional RIR is enhanced and adapted to create a binaural representation of a modified room. A listening experiment has been performed to evaluate the procedure and to investigate differences between synthesized and measured BRIRs. The advantages of this method are obvious: Planned room modifications can be made audible without complex measurements or simulations; just one omnidirectional RIR is required to provide a binaural representation of the desired acoustic treatment.
A 1.8 mW CMOS ΣΔ modulator with integrated mixer for A/D conversion of IF signals (2003)

This CMOS IF/spl Sigma//spl Delta/ modulator combines the functions of an IF mixer and an anti-aliasing filter with a continuous-time (CT) baseband /spl Sigma//spl Delta/ modulator for A/D conversion of IF signals in radio receivers. Advantage is taken of the high linearity and low-power of the CT baseband /spl Sigma//spl Delta/ modulator. The resulting IF/spl Sigma//spl Delta/ modulator consumes 1.8 mW and has +36 dBV IP3. The IF /spl Sigma//spl Delta/ modulator of this paper is for mobile phones (GSM specification), and is promising for application in other types of receivers.
Adalimumab Induction Dose Reduces the Risk of Hospitalizations and Colectomies in Patients with Ulcerative Colitis During the First 8 Weeks of Therapy (2012)

Purpose: Analysis of data from 2 double-blind, placebo controlled trials (ULTRA 1 and 2) revealed that adalimumab (ADA) maintenance therapy reduces hospitalization in patients with moderate to severe ulcerative colitis (UC) through Week 52.1 The impact of ADA induction dosing on hospitalization and colectomy has not yet been reported. Methods: We assessed the effect of a 160/80/40 mg ADA induction regimen (160 mg at Week 0 and 80 mg at Week 2 followed by adalimumab 40 mg every other week (eow) at Week 4 and Week 6) on the risk of hospitalizations (all-cause, UC-related, and UC- or drug-related) and colectomy during the first 8 weeks of these 2 trials. The pooled dataset included 939 patients (471 ADA, 468 placebo [PBO]). Hospitalization and colectomy events were based on safety reports reviewed by 2 gastroenterologists who were blinded to treatment. Since the exposure was similar between treatment groups, the risk of hospitalizations and colectomies between the groups was compared using Chi-square tests. Results: Significant reductions in the risk of all-cause (44%), UC-related (53%), and UC- or drug-related (50%) hospitalizations were observed in the ADA group compared with PBO (table, P<.05 for all). Although not statistically significant, the relative risk for colectomy was lower (34%) in the ADA group compared with PBO. Conclusion: Patients who received 160/80/40 mg ADA induction dosing had a significantly lower risk of all-cause, UC-related, and UC- and drug-related hospitalizations compared with PBO during the first 8 weeks of therapy. The incidence of colectomy was non-significantly lower in patients receiving ADA induction therapy vs. PBO. These data further support a favorable benefit/risk profile of ADA in UC.
Integration of silicon photonics in bulk CMOS (2014)

The first monolithic process flow integrating silicon photonics on operational bulk CMOS has been developed. Features include deep-trench isolation, polysilicon waveguides, grating couplers, filters, modulators, and detectors. Fully functional on-chip CMOS enables Tx/Rx operation while minimizing interconnect parasitics. With the addition of an external 1280nm source, a fully functional optical link (5Gb/s 2.8pJ/b), capable of wavelength division multiplexing, has been demonstrated. In addition to the polysilicon resonant detector used in the link, a monolithically-integrated Silicon-Germanium selective epitaxial growth based photodetector was developed.
Polyfunctional Organomagnesium and Organozinc Reagents: New Reagents for the Synthesis of Complex Organic Molecules (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Id2 Negatively Regulates B Cell Differentiation in the Spleen (2002)

Early stages of B cell development occur in the bone marrow, resulting in formation of immature B cells. These immature cells migrate to the spleen where they differentiate into mature (B2 or marginal zone (MZ)) cells. This final maturation step is crucial for B cells to become responsive to Ags and to participate in the immune response. Id2 is a helix-loop-helix protein that lacks a DNA-binding region; and therefore, inhibits basic helix-loop-helix functions in a dominant negative manner. In this study, we show that Id2 expression is down-regulated during differentiation of immature B cells into mature B2 and MZ B cells. The high levels of Id2 expressed in the immature B cells result in inhibition of E2A binding activity to an E2 box site. Moreover, mice lacking Id2 show an elevation in the proportion of mature B2 cells in the spleen, while the MZ population in these mice is almost absent. Thus, Id2 acts as a regulator of the differentiation of immature B cells occurring in the spleen, it negatively controls differentiation into mature B2 cells while allowing the commitment to MZ B cells. In the absence of Id2 control, the unregulated differentiation is directed toward the mature B2 population.
Joint estimation of fading channel and data with antenna arrays (2003)

In our previous work, we proposed a Kalman filter framework to track fast fading channels for arrays. A limitation of the algorithm was that hard decisions were needed in estimating the channel. We consider three alternative methods for performance improvement, namely, the per-survivor technique, soft decision feedback, and smoothing. It is shown via simulation that the per-survivor technique can approach perfect decision feedback at high SNRs. Soft decision feedback has a decent performance gain over hard decision feedback while incurring slightly increased computation. Smoothing, though complex, has only limited improvement.
Supplementary Figure 3 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis (2023)

Supplementary Figure 3 from HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
Centrifugal Mixing in Gas and Liquid Fuelled Lean Swirl Stabilized Primary Zones (1985)

A flat bladed axial swirler of 0.7 swirl number has been investigated in a 76 mm diameter combustor with all the combustion air passing through the swirler. Both liquid and gaseous fuels were used with eight injection points on the combustor wall just downstream of the swirler. This wall injection was aimed at the exploitation of centrifugal mixing forces acting on the burnt gas pockets at the wall to send them towards the centre and to displace higher density unburnt gas pockets to the wall and so promote mixing. For both kerosene and propane fuels there was a significant improvement in the combustion efficiency and NOX emissions compared with central fuel injection. For kerosene the NOX emissions were lower than for propane and very close to those for premixed fuel and air. However, for gas oil there was little improvement in performance with wall injection compared with central. This was attributed to the slower vaporisation rate with gas oil coupled with the centrifugal action on the liquid droplets with central injection.
The Clinical Research Tool: A High-Performance Microdialysis-Based System for Reliably Measuring Interstitial Fluid Glucose Concentration (2009)

The CRT demonstrates exceptional reliability of system operation and very good measurement performance. The ability to differentiate between artifacts and physiological effects suggests the use of the CRT as a reference tool in clinical investigations.
Magnetic Field Measurements in Wire-Array Z-Pinches and X Pinches (2005)

We are investigating several techniques to obtain time‐dependent magnetic field measurements in wire‐array Z‐pinches and X‐pinches. One general approach is to use “remote sensing” methods whereby a very small sensor material is placed in the plasma and then is investigated to extract useful information. Faraday rotation of polarized laser light traversing a small area through thin film waveguides coupled to a fine optical fiber is a possibility. While these films may not survive for long in a dense Z‐pinch, they may provide useful information for a significant fraction of the current pulse. We also discuss results of experiments conducted using magnetic CoPt thin films to obtain the maximum magnetic field seen by the film near the end of the load current pulse.
Femtosecond laser direct writing of monocrystalline hexagonal silver prisms (2014)

Bottom-up growth methods and top-down patterning techniques are both used to fabricate metal nanostructures, each with a distinct advantage: One creates crystalline structures and the other offers precise positioning. Here, we present a technique that localizes the growth of metal crystals to the focal volume of a laser beam, combining advantages from both approaches. We report the fabrication of silver nanoprisms—hexagonal nanoscale silver crystals—through irradiation with focused femtosecond laser pulses. The growth of these nanoprisms is due to a nonlinear optical interaction between femtosecond laser pulses and a polyvinylpyrrolidone film doped with silver nitrate. The hexagonal nanoprisms have bases hundreds of nanometers in size and the crystal growth occurs over exposure times of less than 1 ms (8 orders of magnitude faster than traditional chemical techniques). Electron backscatter diffraction analysis shows that the hexagonal nanoprisms are monocrystalline. The fabrication method combines advantages from both wet chemistry and femtosecond laser direct-writing to grow silver crystals in targeted locations. The results presented in this letter offer an approach to directly positioning and growing silver crystals on a substrate, which can be used for plasmonic devices.
Adaptive bit loading for wireless OFDM systems (2002)

We investigate the use of adaptive bit loading in existing OFDM-based W-LAN standards. The performance gain is assessed through simulation and the use of higher-rate codes is considered to improve the performance. Some practical aspects, such as peak-to-average power ratio, channel estimation, signalling and spectral flatness are also addressed.
Le jansénisme, une subversion religieuse réactionnaire ? (2011)

info:eu-repo/semantics/published
AlGaAs laser diodes grown by molecular-beam epitaxy (1986)

The article reports on the characteristics of a III approximately V group compound AlGaAs semiconductor laser diode produced by molecular-beam epitaxy (MBE). TJS and ridge-type DFB lasers are introduced as examples of the high crystal quality and excellent growth control that can be achieved by MBE techniques. These advances suggest that MBE will be suitable for producing the integrated opto-electronic circuits needed to realize high-performance multifunction laser diodes.
Dynamic Mechanical Properties of Candidate Lova and Nitrocellulose Base Gun Propellants after up to 18 Months of Accelerated (High Temperature) Aging (1984)

Abstract : Several candidate low vulnerability (LOVA) propellants and several nitrocellulose (NC) base (single, double, and triple) propellants have been subjected to accelerated aging at 65.5 C and mechanical properties measured. The propellants were investigated in compression after 0, 1, 2, 3, 6, 12, and 18 months. Measurements were made at -45 C and 23 C at a strain rate of approximately 10/sec. Little or no change in the compressive strengths of the candidate LOVA propellants was observed. In contrast, significant decreases in the compressive strengths of double and triple base NC propellants were found. The candidate LOVA propellants thus are more thermally stable than the NC base propellants for the conditions of these studies. Possible processes which account for the observed changes and the relationship of these changes to combustion and ballistic properties are discussed. The compressive strengths of all unaged candidate LOVA propellants investigated are significantly lower than the compressive strengths of unaged NC single, double, and triple base propellants at -45 C and most NC propellants at 23 C.
Self-passivated copper as a gate electrode in a poly-Si thin film transistor liquid crystal display (2001)

Self-passivated copper as a gate electrode in the form of TiO/Cu/TiO/TiN/SiO2 has been obtained by annealing Cu/Ti/TiN/SiO2. The thickness of Ti in Cu/TiTiN was optimized at 150 Å by forming an 80 Å continuous TiO film on the outer surface of the Cu. The multilayer of SiO2/TiO/Cu/TiO/TiN/SiO2 showed stable electrical passivating properties against Cu diffusion into the top or bottom SiO2. Consequently, self-passivated copper has secured the dielectric properties of plasma enhanced chemical vapor deposition SiO2 and can be utilized as a gate electrode in low temperature poly-Si thin film transistor liquid crystal displays without sacrificing the low resistivity of Cu.
Physical Layer Security in AF-Based Cooperative SWIPT Sensor Networks (2022)

Physical layer security (PLS) with radio frequency (RF) energy harvesting (EH) in wireless sensor networks has received significant interest as a technology for secure information transmission and prolonging the network lifetime, as well as improving energy efficiency. This article investigates PLS for a simultaneous wireless information and power transfer (SWIPT) cooperative network, which consists of multiple sensor sources, one EH relay (R), and one destination (D) in the presence of one eavesdropper (E). Furthermore, a low-complexity, suboptimal, yet efficient sensor source selection scheme is proposed. Specifically, one sensor source is chosen to transmit information to the relay and destination such that it obtains the best channel from sensor sources to the relay. Then, by considering two relaying strategies, termed the direct link plus static power splitting-based relaying (SPSR) and direct link plus optimal dynamic power splitting-based relaying (ODPSR), the performance analysis in terms of intercept probability (IP) and outage probability (OP) is carried out for each one. Notably, the eavesdropper and destination utilize maximal ratio combining (MRC) to incorporate the received signals from the selected sensor source and the relay, which poses new challenges in obtaining the analytical expressions. In this context, we derive analytical expressions for the OP (for SPSR and ODPSR) at the destination and the IP (for SPSR) at the eavesdropper by adopting the series representation of the modified Bessel function. Finally, Monte Carlo simulations are conducted to validate the theoretical analysis and the proposed schemes’ effectiveness. Simulation results show the superiority of our scheme compared to the benchmarks.
A Goal-Driven Natural Language Interface for Creating Application Integration Workflows (2022)

Web applications and services are increasingly important in a distributed internet filled with diverse cloud services and applications, each of which enable the completion of narrowly defined tasks. Given the explosion in the scale and diversity of such services, their composition and integration for achieving complex user goals remains a challenging task for end-users and requires a lot of development effort when specified by hand. We present a demonstration of the Goal Oriented Flow Assistant (GOFA) system, which provides a natural language solution to generate workflows for application integration. Our tool is built on a three-step pipeline: it first uses Abstract Meaning Representation (AMR) to parse utterances; it then uses a knowledge graph to validate candidates; and finally uses an AI planner to compose the candidate flow. We provide a video demonstration of the deployed system as part of our submission.
Serum antibodies specific for tumor antigens in colorectal cancer may be useful diagnostic biomarkers (2006)

10041 Background: Colorectal cancer is immunogenic as evidenced by the presence of antibodies specific to tumor antigens in patient serum and T cell infiltration at the tumor site predicting favorable disease outcome. We questioned whether antibody immunity to tumor associated antigens (TAA) in patients with colorectal cancer could be used as a biomarker to predict disease. Methods: We evaluated serum samples for the presence of antibody immunity to six tumor antigens, cyclin D1, HER-2/neu, insulin-like growth factor binding protein 2 (IGFBP2), NY-ESO-1, p53, and topoisomerase-IIα (TOPO2α), in colorectal cancer patients (n=40) and normal donors (n=200) using ELISA. We then evaluated the diagnostic value of these potential biomarkers by measuring antibody levels to these TAA in an independent sample set which included 30 colorectal cancer patients and 135 normal donors. The samples were judged as positive or negative for colorectal cancer using measurements derived either from a single marker or a combination of the markers. Receiver operating characteristic (ROC) plots were generated to determine the diagnostic accuracy of each test. Results: Colorectal cancer patients had increased levels of antibodies to p53 (p=0.002), TOPO2α (p&lt;0.001), and IGFBP2 (p&lt;0.001) compared to controls. By using a combination of just two antibody measurements, TOPO2α and IGFBP2, we could discriminate colorectal cancer patients from controls with a diagnostic power of 0.775 as estimated by the area under ROC curve. At a cutoff point of 0.03 mcg/ml TAA specific IgG, the sensitivity was 100% and the specificity was 58%. Conclusions: Serum antibodies to colorectal cancer related antigens may serve as useful biomarkers for colorectal cancer diagnosis. No significant financial relationships to disclose.
Flame Spray Pyrolysis for Preparing Red-Light-Emitting, Submicron-Sized Luminescent Strontium Titanate Particles (2006)

SrTiO3:Pr3+,Al3+ red-light-emitting phosphor particles were directly prepared by flame spray pyrolysis without any post-heat treatments. The morphology, crystallinity and photoluminescence (PL) of the as-prepared SrTiO3:Pr3+,Al3+ particles were systematically investigated. The as-prepared particles showed good morphological characteristics and a high crystallinity. The geometric mean diameters of the particles ranged from 0.53 to 0.70 µm. The particles showed a bright red emission at 615 nm from 1D2–3H4 transition under 365 nm excitation. Optimization to the enhance PL was conducted by systematically controlling gas flow rates, and activator, additive and salt-flux concentrations. The highest PL intensity at 615 nm was obtained at Pr/Ti and Al/Ti molar ratios of 0.001 and 0.03, respectively, and a 40 mol % LiNO3 flux. The photoluminescence intensity of submicron-sized SrTiO3:Pr3+,Al3+ particles prepared under the optimal synthetic conditions was as high as 107% that of micron-sized particles prepared by a solid-state reaction.
Combination Immunotherapy of Advanced Lymphoma with Oncolytic Vaccinia Virus and Checkpoint Inhibitor Following Local Tumor Irradiation (2014)

Abstract Oncolytic virotherapy is safe and clinically active in solid tumors, however its efficacy in hematologic malignancies as well as in combination with checkpoint inhibitors and radiation is unexplored.To simulate advanced lymphoma, A20 lymphoma cells were injected subcutaneously on bilateral flanks of BALB/c mice and treatment initiated on day 17 to only the right flank tumor with local irradiation (Irr), intratumoral (i.t.) vaccinia virus (VACV) and i.t. anti-CTLA-4 mAb (Irr-VACV-CTLA4, Figure 1). The Irr-VACV-CTLA4 regimen was the most effective in eradicating or shrinking both treated and untreated tumors and extending survival, followed by the Irr-VACV regimen. Treatment with Irr-VACV-CTLA4, led to initially a mature, activated NK cell (KLRG1+CD27+) infiltrate (day 6 post-treatment) followed by a CD8+T cells infiltrate (day+13) in treated tumors. In contrast, treatment with VACV-CTLA4 led to activated NK-cell accumulation (day +6) followed by a CD8+T-cell infiltrate (day+13) in non-treated tumors. Importantly, CD8+CD44hi T cells isolated from the blood and spleens of the treated mice showed functional specificity to A20 lymphoma cells, but not to MHC-matched tumor cells (CT26) in intra-cellular stains for IFN-g. Splenocyte-derived A20-specific CD8+CD44hi T cells were induced most efficiently in the Irr-VACV-CTLA4 regimen-treated mice, while blood-derived A20-specific CD8+CD44hi T cells were induced most efficiently in the Irr-VACV regimen-treated mice. Viral plaque assays (VPA) showed lack of live viral particles in both treated and untreated tumors upon sacrificing mice 4 to 10 weeks after treatment initiation. Surprisingly, VPA assays identified live virus in the livers of Irr-VACV-CTLA4 regimen-treated mice, which paralleled a reduced metastatic load. Our findings are the first to demonstrate the potential of combination immunotherapy with oncolytic viruses and checkpoint inhibitors in hematologic malignancies. The antitumor activity is attributed to the induction of an effective and specific immune response. This finding is corroborated by the significant infiltration with mature activated NK cells, followed by CD8+T cells, in both treated and untreated tumors. Importantly, the tumor-specific CD8+T cells showing a memory phenotype (CD44hi) suggest the effective induction of a potent immune memory response. Effective targeting of distant metastases after intratumoral administration is also an important finding with significant clinical implications. This novel combination immunotherapy with oncolytic viruses and checkpoint inhibitors following local tumor irradiation is now being translated to a Phase 1 proof-of-concept clinical trial in non-Hodgkin's lymphoma at our institution. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
Optimal tilings and best basis search in large dictionaries (2004)

We develop a new framework of multitree dictionaries which include many previously proposed dictionaries as special cases. We show how to efficiently find the best object in a multitree dictionary using a recursive dynamic programming algorithm. We apply our framework to find the best rectangular tiling of an image domain.
A Thin-Base Lateral Bipolar Transistor Fabricated on Bonded SOI (1991)

In this paper, we describe a thin-base lateral BJT fabricated on bonded SOI, and explore the device's characteristics. High gain, high-speed AC characteristics and no leakage current range are obtained due to both the thin base and the fine crystallization of the bonded SOI film.