gebhart/patrepeval huggingface dataset:
Investigation of Ether-Substituted Quaternary Ammonium Ionic Liquids (2007)

The effect of structural rigidity in quaternary ammonium-based ionic liquids (ILs) was investigated. and , both 8 atom (7 carbons, 1 oxygen) ether-substituted quaternary ammonium chlorides (Quats), were syn thesized and investigated. In acetonitrile, placement of the oxygen one atom from the nitrogen (Quat I) resulted in a significant decrease in the reductive stability. While the IL form showed similar stability for the two systems, placing the oxygen close to the nitrogen (methyl ethyl ether) appears to localize a greater portion of the positive charge on the nitrogen. This results in an IL with a higher melting point than the nonether analog, (III, ) IL. In contrast, placing two carbon atoms between the nitrogen and ether group, ethyl methyl ether (Quat II), delocalizes the positive charge from the nitrogen and produces a room-temperature IL. Neutralization of the acidic IL with sodium chloride resulted in an increase in the bulk conductivity, due to the polar ether group. Upon addition of or , which both form a solid-electrolyte interphase on the substrate surface, the increased free sodium ion concentration allowed sodium reduction and oxidation currents greater than at room temperature.
Low-Temperature, High-Performance Solution-Processed Thin-Film Transistors with Peroxo-Zirconium Oxide Dielectric (2012)

We demonstrated solution-processed thin film transistors on a peroxo-zirconium oxide (ZrO(2)) dielectric with a maximum temperature of 350 °C. The formation of ZrO(2) films was investigated by TG-DTA, FT-IR, and XPS analyses at various temperatures. We synthesized a zirconium oxide solution by adding hydrogen peroxide (H(2)O(2)). The H(2)O(2) forms peroxo groups in the ZrO(2) film producing a dense-amorphous phase and a smooth surface film. Because of these characteristics, the ZrO(2) film successfully blocked leakage current even in annealing at 300 °C. Finally, to demonstrate that the ZrO(2) film is dielectric, we fabricated thin-film transistors (TFTs) with a solution-processed channel layer of indium zinc oxide (IZO) on ZrO(2) films at 350 °C. These TFTs had a mobility of 7.21 cm(2)/(V s), a threshold voltage (V(th)) of 3.22 V, and a V(th) shift of 1.6 V under positive gate bias stress.
Sustained Release Device Containing Metronidazole for Periodontal Use (1984)

The purpose of this study was to develop a sustained release device containing metronidazole for insertion within periodontal pockets and to examine the release kinetics in vitro and in vivo. Cast films of ethyl cellulose with or without polyethylene glycol, containing metronidazole, were prepared and exhibited sustained release. Release rate of metronidazole from the film was measured by means of a UV spectrophotometer, and kinetics of release in vitro was found to conform to Higuchi's diffusional model. The microbiological results proved that embedding metronidazole in ethyl cellulose film does not inhibit the biological activity. The release kinetics in vivo correlated with in vitro results, exhibiting a sustained release of metronidazole over a period of three days from 30% metronidazole with polyethylene glycol or 40% metronidazole in ethyl cellulose chloroform cast. This study demonstrates that, by embedding metronidazole in ethyl cellulose, it is possible to obtain sustained release of the drug within the periodontal pocket for three days.
ChemInform Abstract: A New Facile Method for the Stereoselective Synthesis of trans‐2‐Aryl‐3,3‐dimethylcyclopropane‐1‐carboxylic Acids. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermal Decomposition of Generation-4 Polyamidoamine Dendrimer Films:  Decomposition Catalyzed by Dendrimer-Encapsulated Pt Particles (2005)

The thermal decomposition of hydroxyl-terminated generation-4 polyamidoamine dendrimer (G4OH) films deposited on Au surfaces has been compared with decomposition of the same dendrimer encapsulating an approximately 40-atom Pt particle (Pt-G4OH). Infrared absorption reflection spectroscopy studies showed that, when the films were heated in air to various temperatures up to 275 degrees C, the disappearance of the amide vibrational modes occurred at lower temperature for the Pt-G4OH film. Dendrimer decomposition was also investigated by thermogravimetric analysis (TGA) in both air and argon atmospheres. For the G4OH dendrimer, complete decomposition was achieved in air at 500 degrees C, while decomposition of the Pt-G4OH dendrimer was completed at 400 degrees C, leaving only platinum metal behind. In a nonoxidizing argon atmosphere, a greater fraction of the G4OH decomposed below 300 degrees C, but all of the dendrimer fragments were not removed until heating above 550 degrees C. In contrast, Pt-G4OH decomposition in argon was similar to that in air, except that decomposition occurred at temperatures approximately 15 degrees C higher. Thermal decomposition of the dendrimer films on Au surfaces was also studied by temperature programmed desorption (TPD) and X-ray photoelectron spectroscopy (XPS) under ultrahigh vacuum conditions. Heating the G4OH films to 250 degrees C during the TPD experiment induced the desorption of large dendrimer fragments at 55, 72, 84, 97, 127, 146, and 261 amu. For the Pt-G4OH films, mass fragments above 98 amu were not observed at any temperature, but much greater intensities for H(2) desorption were detected compared to that of the G4OH film. XPS studies of the G4OH films demonstrated that significant bond breaking in the dendrimer did not occur until temperatures above 250 degrees C and heating to 450 degrees C caused dissociation of C=O, C-O, and C-N bonds. For the Pt-G4OH dendrimer films, carbon-oxygen and carbon-nitrogen bond scission was observed at room temperature, and further decomposition to atomic species occurred after heating to 450 degrees C. All of these results are consistent with the fact that the Pt particles inside the G4OH dendrimer catalyze thermal decomposition, allowing dendrimer decomposition to occur at lower temperatures. However, the Pt particles also catalyze bond scission within the dendrimer fragments so that decomposition of the dendrimer to gaseous hydrogen is the dominant reaction pathway compared to desorption of the larger dendrimer fragments observed in the absence of Pt particles.
Abstract 2713: Molecular Imaging of Cardiac Stem Cell Mediated Angiogenic Gene Therapy (2006)

Introduction: Cardiac stem cell therapy remains hampered by acute donor cell death post transplant and the lack of reliable methods for tracking cell survival in vivo. We hypothesize that cells cap...
PUFmeter a Property Testing Tool for Assessing the Robustness of Physically Unclonable Functions to Machine Learning Attacks (2019)

As PUFs become ubiquitous for commercial products (e.g., FPGAs from Xilinx, Altera, and Microsemi), attacks against these primitives are evolving toward more omnipresent and even advanced techniques. Machine learning (ML) attacks, among other non-invasive attacks, are proven to be feasible and cost-effective in the real-world. However, for PUF designers, it still remains an open question whether their countermeasures, or even new designs, are resistant to these types of attacks. Although standard metrics for estimating PUF quality exist, the most common approaches for measuring resistance to ML attacks are empirical. This paper introduces PUFmeter, a new publicly available toolbox consisting of in-house developed algorithms, to provide a firm basis for the robustness assessment of PUFs against ML attacks. To this end, new metrics and notions are reintroduced by PUFmeter to PUF designers and manufacturers. Furthermore, to prepare the PUF input-output pairs adequately before conducting any analysis, PUFmeter involves modules that output the minimum number of measurement repetitions and the upper bound on the noise level affecting the PUF responses.
ETA and ETB receptors on single smooth muscle cells cooperate in mediating guinea pig tracheal contraction (1994)

We investigated the distribution of endothelin A (ETA) and ETB receptors in single smooth muscle cells and their contribution to ET-induced contractions of guinea pig trachea. ETA and ETB receptors were detected in smooth muscle membranes (maximum binding capacities of 810 and 360 fmol/mg protein and dissociation constants of 38 and 5.1 pM for 125I-labeled ET-1 and 125I-ET-3, respectively) and visualized autoradiographically in primary cultured cells. ET-1 and ET-3 evoked concentration-dependent increases in intracellular Ca2+ concentration and smooth muscle tension. The half-maximally effective concentrations of ET-1 and ET-3 at inducing contractions were 1.9 and 2.7 nM, respectively. The Ca2+ responses showed tachyphylaxis to both ETs after stimulation with ET-1, but only to ET-3 after stimulation with ET-3. Consecutive applications of ET-3 and ET-1 (10 nM each) classified the cells into ETA dominant (approximately 30%) responding to only ET-1, ETB dominant (approximately 20%) responding to only ET-3, and ETA- and ETB-possessing (approximately 50%) cells responding to both. The ETA antagonist, 10 microM BQ-123, attenuated ET-1-induced contractions but did not affect the ET-3-induced contractions. The results indicate that both receptors coexist in a major population of smooth muscle cells and cooperate in mediating ET-1-induced contractions.
Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers (2015)

Exposure of individuals to ionizing radiation (IR), as in the case of astronauts exploring space or radiotherapy cancer patients, increases their risk of developing secondary cancers and other health-related problems. Bone marrow (BM), the site in the body where hematopoietic stem cell (HSC) self-renewal and differentiation to mature blood cells occurs, is extremely sensitive to low-dose IR, including irradiation by high-charge and high-energy particles. Low-dose IR induces DNA damage and persistent oxidative stress in the BM hematopoietic cells. Inefficient DNA repair processes in HSC and early hematopoietic progenitors can lead to an accumulation of mutations whereas long-lasting oxidative stress can impair hematopoiesis itself, thereby causing long-term damage to hematopoietic cells in the BM niche. We report here that low-dose (1)H- and (56)Fe-IR significantly decreased the hematopoietic early and late multipotent progenitor (E- and L-MPP, respectively) cell numbers in mouse BM over a period of up to 10 months after exposure. Both (1)H- and (56)Fe-IR increased the expression of pluripotent stem cell markers Sox2, Nanog, and Oct4 in L-MPPs and 10 months post-IR exposure. We postulate that low doses of (1)H- and (56)Fe-IR may induce endogenous cellular reprogramming of BM hematopoietic progenitor cells to assume a more primitive pluripotent phenotype and that IR-induced oxidative DNA damage may lead to mutations in these BM progenitors. This could then be propagated to successive cell lineages. Persistent impairment of BM progenitor cell populations can disrupt hematopoietic homeostasis and lead to hematologic disorders, and these findings warrant further mechanistic studies into the effects of low-dose IR on the functional capacity of BM-derived hematopoietic cells including their self-renewal and pluripotency.
Supplementary Figure S4 from CMVpp65 Vaccine Enhances the Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV-Specific T Cells (2023)

&lt;p&gt;Supplementary Figure S4. Enhanced anti-tumor activity of adoptively transferred bi-specific T cells by CMV vaccine for replased tumor&lt;/p&gt;
Tendon Transfer Options for Trapezius Paralysis: A Biomechanical Study (2018)

Level V, biomechanical study.
The use of a TLR2 agonist‐based adjuvant for enhancing effector and memory CD8 T‐cell responses (2014)

We have previously shown that the immunogenicity of protein antigens can be significantly enhanced if electrostatically associated with the Toll-like receptor-2 agonist-based lipopeptide R4Pam2Cys. The precise mechanisms and effectiveness of the cytotoxic T-lymphocyte (CTL)-mediated response facilitated by this agonist, however, have not been studied. Here we show that priming by dendritic cells (DCs) in the draining lymph nodes of animals vaccinated with antigen delivered using R4Pam2Cys results in significantly improved T-cell proliferation and induces their differentiation into polyfunctional effector CTLs characterised by granzyme B expression and the ability to secrete interferon-γ, interleukin-2 and tumor necrosis factor-α 7 days after vaccination. After 30 days, frequencies of antigen-specific CD62(low)CD127(high) (effector memory), CD62(high)CD127(high) (central memory) and CD43(low)CD27(high) CD8(+) T cells, a phenotype associated with strong recall responses against respiratory infections, are also increased compared with responses obtained with antigens formulated in the adjuvants Alum (alhydrogel) and CFA (complete Freund's adjuvant). The phenotypic changes observed in these mice vaccinated using R4Pam2Cys further correlated with their ability to recall specific T cells into the lung to mediate the reduction of pulmonary viral titres following challenge with a chimeric influenza virus containing the K(b)OVA257-264 epitope compared with animals vaccinated using Alum or CFA. The findings from this study not only demonstrate that better T-cell responses can be elicited using R4Pam2Cys compared with classically utilised adjuvants but also highlight the potential effectiveness of this lipopeptide-based adjuvant particularly against viral infections that require resolution through cell-mediated immunity.
Supplementary Figure 6 from Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway (2023)

&lt;p&gt;PDF file - 64K, IGF1R and pIGFR1R levels are similar in the PFR3 and PFR3+, and WZR4 and WZR4+ cells&lt;/p&gt;
Aminopeptidases from Human Leucocytes (1984)

Six aminopeptidases differing in enzymic specificity against various L-amino acid-4-nitroanilides were detected and isolated from the cytosol of leucocytes collected from the buffy coat of human blood. The different enzymes were separated by one step of chromatography on DEAE-Sephacel and were further purified by gel filtration on Sephacryl S-300. The main aminopeptidases of the cytosol were designated aminopeptidases 1, 2, 4 and 5 (AP 1, AP 2, AP 4, AP 5) on the basis of their elution sequence from the first ion-exchange chromatography column on DEAE-Sephacel. Aminopeptidase 1 appeared to be a strongly sulfhydryl-dependent leucine aminopeptidase, activatable by thiol reagents. The enzyme was inhibited by p-chloromercuribenzoate. Its molecular mass was estimated to be 150 kDa. Aminopeptidase 2 showed high specificity for proline-4-nitroanilide. This enzyme was inhibited by p-chloro-mercuribenzoate and bestatin. It exhibited a molecular mass of 70 kDa. Aminopeptidase 4 designated the activities of two different enzymes of apparent molecular masses of 220 and 70 kDa which could be further separated by gel filtration. Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine. The molecular mass was estimated to be 90 kDa. Aminopeptidase 3 was a minor component in the cytosol and could be identified as an extracellular leucocyte plasma membrane constituent. The enzyme exhibited properties of a metallo proteinase and could be inhibited by EDTA. The molecular mass was estimated to be 250 kDa.
Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells (2003)

We investigated the kinetics of expression of 12 chemoattractant receptors as a function of cell division following priming of human naive CD4+ T cells by different populations of dendritic cells (DC) and under conditions favoring Th1 or Th2 differentiation. Two chemokine receptors, CXCR3 and CXCR5, were rapidly up-regulated following T cell activation by either monocyte-derived DC, myeloid DC (mDC) or plasmacytoid DC (pDC). While CXCR5 expression was transient, expression of CXCR3 at advanced cell divisions was dependent on differentiation, being expressed at high levels on Th1 cells. Several other receptors (CCR2, CCR3, CCR4, CCR5, CXCR6 and CRTh2) were acquired progressively as a function of cell division and in a fashion that was influenced by polarizing cytokines. The Th2-associated chemoattractant receptors CRTh2 and CCR3 were up-regulated with slower kinetics compared to the Th1-associated receptors CXCR3 and CXCR6, consistent with a different kinetics and efficiency of polarization. Moreover, CCR4 and CXCR6 were preferentially induced in T cells activated by mDC and pDC, respectively. Finally, CXCR5 and CCR7 were also rapidly and transiently up-regulated in memory T cells following TCR stimulation. These results indicate a complex chemokine receptor regulation dependent on both T cell activation and differentiation state. In addition, they reveal the existence of DC-specific cues for the regulation of T cell migratory capacity.
A KrF excimer laser induced dehydrochlorination of a chlorinated poly(vinyl chloride): Preparation of conjugated polyene and polyyne (1992)

Abstract The photochemical dehydrochlorination of a chlorinated poly(vinyl chloride) film was investigated with respect to the preparation of a π‐electron‐conjugated polymer. The dehydrocholorination proceeds more effectively upon irradiation with a KrF excimer laser than with a low‐pressure mercury lamp, showing the formation of new absorption bands in the range 300–800 nm. The most effective condition provided KrF excimer laser irradiation of 25− 30 mJ/cm 2 at 1 Hz in a vacuum chamber of 10 −6 Torr at 90°C. The surface of the irradiated film was analyzed by IR (attenuated total reflection method), X‐ray photoelectron and Raman spectroscopy. The characteristic peaks (1 112, 1 488 and 2 188 cm −1 ) in the Raman spectrum were ascribed to a structure having eight conjugated CC bonds and twenty conjugated CC bonds.
Optimizing the shape of InAs/InP quantum dot-nanowires grown by MBE on silicon for efficient light sources emitting in the telecom band (2019)

International audience
Waveguiding in silicon photonic crystal slabs – thrust toward ultradense optical integration (2004)

We will review the latest results on development of submicron silicon-on-insulator waveguiding structures – photonic crystals (PhC) and single-mode strip waveguides. We will show that two major problems, which hindered the development of the silicon micro-photonics technology, large waveguide propagation losses and large coupling losses to submicron high index waveguides, have been solved [1-4]. Further optimization of mode matching at interfaces between fiber coupler, strip waveguides and PhC allow elimination of parasitic back-reflections in the optical circuit and suppress Fabry-Perot noise. Clean optical spectra obtained from fiber-coupled devices make it possible to extract detailed quantitative information on the characteristics of each component in the circuit and to perform direct fitting of the transmission with 3D FDTD and band structure calculations.
When Chirophotonic Film Meets Wrinkles: Viewing Angle Independent Corrugated Photonic Crystal Paper (Adv. Mater. 1/2023) (2023)

Photonic Crystal Papers In article number 2206764, Dae-Yoon Kim, Kwang-Un Jeong, and co-workers develop 1D stripe and 2D wavy wrinkled photonic crystal papers to demonstrate consistent reflection of colors regardless of viewing angle. The nanoscale molecular self-assembly of cholesteric liquid crystal is combined with a microscale corrugated surface. The wrinkled photonic crystal papers can open a new door for the development of smart chirophotonic materials.
Fabrication and characterization of novel photodefined polymer-enhanced through-silicon vias for silicon interposers (2013)

To attain high bandwidth communication between chips at lower power consumption, silicon interposers with dense metallization and through-silicon vias (TSVs) have been widely explored. However, TSV electrical losses increase as TSV height increases and are generally high in low-resistivity silicon. To alleviate this issue, we demonstrate a silicon interposer technology featuring photodefined polymer embedded vias. High-frequency measurements are performed for the fabricated polymer-embedded vias, yielding approximately 1 dB insertion loss at 50 GHz.
A Load-Balanced Parallel and Distributed Sorting Algorithm Implemented with PGX.D (2016)

Sorting has been one of the most challenging studied problems in different scientific researches. Although many techniques and algorithms have been proposed on the theory of having efficient parallel sorting implementation, however achieving desired performance on different types of the architectures with large number of processors is still a challenging issue. Maximizing parallelism level in applications can be achieved by minimizing overheads due to load imbalance and waiting time due to memory latencies. In this paper, we present a distributed sorting algorithm implemented in PGX.D, a fast distributed graph processing system, which outperforms the Spark's distributed sorting implementation by around 2x-3x by hiding communication latencies and minimizing unnecessary overheads. Furthermore, it shows that the proposed PGX.D sorting method handles dataset containing many duplicated data entries efficiently and always results in keeping balanced workloads for different input data distribution types.
Astrocytes promote ethanol-induced enhancement of intracellular Ca2+ signals through intercellular communication with neurons (2021)

Ethanol (EtOH) abuse induces significant mortality and morbidity worldwide because of detrimental effects on brain function. Defining the contribution of astrocytes to this malfunction is imperative to understanding the overall EtOH effects due to their role in homeostasis and EtOH-seeking behaviors. Using a highly controllable in vitro system, we identify chemical signaling mechanisms through which acute EtOH exposure induces a modulatory feedback loop between neurons and astrocytes. Neuronally-derived purinergic signaling primed a subpopulation of astrocytes to respond to subsequent acute EtOH exposures (SEastrocytes: signal enhanced astrocytes) with greater calcium signal strength. Generation of SEastrocytes arose from astrocytic hemichannel-derived ATP and accumulation of its metabolite adenosine within the astrocyte microenvironment to modulate adenylyl cyclase and phospholipase C activity. These results highlight an important role of astrocytes in shaping the overall physiological responsiveness to EtOH and emphasize the unique plasticity of astrocytes to adapt to single and multiple exposures of EtOH.
Deadlock-free class routes for collective communications embedded in a multi-dimensional torus network (2023)

A computer implemented method and a system for routing data packets in a multi-dimensional computer network. The method comprises routing a data packet among nodes along one dimension towards a root node, each node having input and output communication links, said root node not having any outgoing uplinks, and determining at each node if the data packet has reached a predefined coordinate for the dimension or an edge of the subrectangle for the dimension, and if the data packet has reached the predefined coordinate for the dimension or the edge of the subrectangle for the dimension, determining if the data packet has reached the root node, and if the data packet has not reached the root node, routing the data packet among nodes along another dimension towards the root node.