gebhart/patrepeval huggingface dataset:
PD/SOI SRAM performance in presence of gate-to-body tunneling current (2003)

This paper presents a detailed study on the effects of gate-to-body tunneling current on partially depleted silicon-on-insulator (PD/SOI) CMOS SRAM. It is shown that the presence of gate-to-body tunneling current changes the strength of individual cell transistor in the quiescent (standby) state, thus affecting subsequent write/read operations. The degradation in the "write" performance is shown to be more significant than the degradation in the "read" performance, and the effect is more pronounced at lowered temperature. For the beneficial side, the presence of the gate-to-body tunneling current reduces the initial cycle parasitic bipolar disturb from unselected cells on the same bitline during write/read operation.
A multivariate analysis of social dominance in children (1978)

The social dominance behavior of dyads of unacquainted, same-sex 31/2 year-olds was observed in a familiar laboratory playroom under two conditions: A free play situation and a situation where candy was introduced. In each of the two conditions, a principal components analysis was used to explore two issues: the usefulness of the multivariate approach in devising a definition of dominance, and the cross-situational stability of the construct. In the free play session, the first principal component that emerged was consistent with a theoretical definition of dominance. This picture was disrupted by the introduction of candy in the second condition. However, a high correlation was found between the dominance hierarchies established in each situation. It was concluded that the multivariate analysis is a useful method for the study of dominance. The generalizability of social dominance across settings was discussed as a possible explanation for the high cross-situational stability.
Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection (2014)

Semen, the most common vehicle for HIV transmission, enhances HIV infection in vitro, but how long it retains this activity has not been investigated. Semen naturally undergoes physiological changes over time, whereby it converts from a gel-like consistency to a more liquid form. This process, termed liquefaction, is characterized at the molecular level by site-specific and progressive cleavage of SEMs, the major components of the coagulum, by seminal proteases. We demonstrate that the HIV-enhancing activity of semen gradually decreases over the course of extended liquefaction and identify a naturally occurring semenogelin-derived fragment, SEM1(86-107), whose levels correlate with virus-enhancing activity over the course of liquefaction. SEM1(86-107) amyloids are naturally present in semen, and synthetic SEM1(86-107) fibrils bind virions and are sufficient to enhance HIV infection. Therefore, by characterizing dynamic changes in the HIV-enhancing activity of semen during extended liquefaction, we identified SEM1(86-107) to be a key virus-enhancing component of human semen.
Synthesis of vinca alakaloids and realated compounds 98. Oxidation with dimethyldioxirane of compounds containing the aspidospermane and quebrachamine ring system. A simple synthesis of (7S,20S)‐(+)‐rhazidigenine and (2R,7S,20S)‐(+)‐rhazidine (2002)

Abstract The oxidation of (‐)‐tabersonine ( 1 ) with dimethyldioxirane (DMD) in neutral and acidic medium gave 16‐hydroxytabersonine‐ N ‐oxide ( 3 ) and the didehydrovincamine isomers 4 and 5 , respectively. (+)‐14,15‐Didehydro‐quebrachamine ( 7 ) furnished the hydroxyindolenine 9 , and the pentacyclic derivative 11 . (+)‐Quebrachamine ( 8 ) and DMD in neutral medium gave (7 S ,20 S )‐(+)‐rhazidigenine ( 12 ) which was converted to (2 R ,7 S ,20 S )‐(+)‐rhazidine ( 13b ) with hydrochloric acid.
Use of Monoclonal Antibodies for Expression Cloning (2003)

This unit details the use of transient expression in mammalian cells to screen cDNA libraries with monoclonal antibodies (MAb) to isolate cDNA clones encoding cell-surface and intracellular proteins. The first protocol in this unit describes the cloning of cDNAs encoding cell-surface antigens. Several steps in this protocol involve transfection procedures that are described in greater detail elsewhere in this volume. The second protocol is a modification that facilitates isolation of cDNAs encoding antigens that are expressed intracellularly. Both protocols are designed for use with the expression vector CDM8, which contains a polylinker for subcloning double-stranded cDNA.
Cytomegalovirus Interleukin-10 Expression in Infected Cells Does Not Impair MHC Class I Restricted Peptide Presentation on Bystanding Antigen-Presenting Cells (2006)

Human cytomegalovirus (HCMV) has evolved strategies to counteract its surveillance by the immune system. Mitigation of antiviral immune responses is considered critical for establishment of viral latency and for spread. Recently, a gene encoding an interleukin-10 homologue (cmvIL-10) has been discovered in the HCMV genome. Using recombinant cmvIL-10, several mostly immunosuppressive functions of the molecule have been described. However, the role of cmvIL-10 in the context of viral infection was not addressed. To be able to analyze this issue, we generated cmvIL- 10-negative viral mutants. Using these mutants, we tested whether the expression of cmvIL-10 by infected cells would render bystander antigen-presenting cells less efficient in their capacity to present antigenic peptides in the context of MHC class I. To test this, CTL clones specific for the viral nonapeptides P65(495-503) and IE1(297-305) were used as tools. Culture supernatant from fibroblasts infected with cmv-IL10-negative viruses was supplemented with increasing concentrations of recombinant cmvIL-10. Treatment of human THP-1 cells with these conditioned media did not impair their capacity to present HCMV-derived nonapeptides in the context of MHC-class I, even when high concentrations of cmvIL-10 were used. To investigate whether close cell contact was important, fibroblasts were infected with either wild-type HCMV or cmvIL-10 null mutants and were cocultured with nonpermissive lymphoblastoid cell lines, serving as target cells. No correlation was found between the ability of HCMV strains to express the cmvIL-10 gene and the capacity of neighboring LCL to present peptides in the context of MHC class I. Consequently, we propose that cmvIL- 10 expressed in the context of HCMV infection has no direct impact on MHC class I-restricted antigen presentation of noninfected bystander cells.
Palm area detection for reliable hand gesture recognition (2013)

Abstract—Hand gesture recognition applications require as a first step a reliable identification of the hand region and its subdivision into fingers and palm areas. In this work the hand is firstly extracted from the depth data acquired by a depth sensor (e.g., Microsoft Kinect). Then the center of the palm and the hand orientation are identified. Finally circular and elliptical shapes are fitted on the extracted samples in order to reliably identify the palm and fingers area. The proposed approach has been tested inside a simple gesture recognition scheme and preliminary results show its reliability. I.
Thermal Conductivity of ZrB2SiCB4C from 25 to 2000 °C (2013)

Abstract The thermal diffusivities of ZrB 2 –SiC (10.7, 21.9, or 48.7 vol% SiC) with B 4 C sintering aid were measured over 25–2000 °C using laser flash. The composition with the highest SiC showed the highest thermal conductivity ( k ) at 25 °C, but the lowest above ≈400 °C, because of the greater k temperature sensitivity of the SiC phase. Finite difference calculations of k , using selected literature data for the individual phases, and the concentration of phases from microstructures, correctly predicted temperature and phase concentration dependencies, but were lower than experimental results. The k of pure ZrB 2 and SiC as a function of temperature were back‐calculated from the experimental results for the multi‐phase materials; they were in good agreement with specific literature values.
Long‐term changes in the acid and salt concentrations of the Greenland Ice Core Project ice core from electrical stratigraphy (1995)

Continuous electrical records covering a climatic cycle are presented for the Greenland Ice Core Project deep ice core from Greenland. Electrical conductivity measurement (ECM) measures the acid content of the ice, and the dielectric profile (DEP) responds to acid, ammonium, and chloride. All features seen can be explained by chemical changes in the ice, and there is no evidence so far for any major change in electrical response with depth or age of the ice. Both records are dominated by the acidity of the ice which varies strongly from acidic in warm periods to alkaline in cold periods, controlled by neutralization by alkaline dust (calcareous and other mineral dust). When Ca is low, the acidity (mainly nitric acid) has a fairly constant background level throughout the cycle, with slightly lower values in ice believed to be from the last interglacial. Ca has to rise only slightly to neutralize the available acidity, so that acidity is a highly nonlinear reflection of climate changes. If neutralization occurred in the aerosol (rather than in the ice), then the number of cloud condensation nuclei over parts of the northern hemisphere could have been reduced, leading to reduced cloud albedo. This nonlinear feedback may have some importance for modeling of climate change. When both acid and ammonium levels are low, the DEP signal can be used to give a rapid indication of chloride trends.
Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling (2016)

The four members of the epidermal growth factor receptor (EGFR/ERBB) family form homo- and heterodimers which mediate ligand-specific regulation of many key cellular processes in normal and cancer tissues. While signaling through the EGFR has been extensively studied on the molecular level, signal transduction through ERBB3/ERBB4 heterodimers is less well understood. Here, we generated isogenic mouse Ba/F3 cells that express full-length and functional membrane-integrated ERBB3 and ERBB4 or ERBB4 alone, to serve as a defined cellular model for biological and phosphoproteomics analysis of ERBB3/ERBB4 signaling. ERBB3 co-expression significantly enhanced Ba/F3 cell proliferation upon neuregulin-1 (NRG1) treatment. For comprehensive signaling studies we performed quantitative mass spectrometry (MS) experiments to compare the basal ERBB3/ERBB4 cell phosphoproteome to NRG1 treatment of ERBB3/ERBB4 and ERBB4 cells. We employed a workflow comprising differential isotope labeling with mTRAQ reagents followed by chromatographic peptide separation and final phosphopeptide enrichment prior to MS analysis. Overall, we identified 9686 phosphorylation sites which could be confidently localized to specific residues. Statistical analysis of three replicate experiments revealed 492 phosphorylation sites which were significantly changed in NRG1-treated ERBB3/ERBB4 cells. Bioinformatics data analysis recapitulated regulation of mitogen-activated protein kinase and Akt pathways, but also indicated signaling links to cytoskeletal functions and nuclear biology. Comparative assessment of NRG1-stimulated ERBB4 Ba/F3 cells revealed that ERBB3 did not trigger defined signaling pathways but more broadly enhanced phosphoproteome regulation in cells expressing both receptors. In conclusion, our data provide the first global picture of ERBB3/ERBB4 signaling and provide numerous potential starting points for further mechanistic studies.
Humidity effects on the redox reactions and ionic transport in a Cu/Ta2O5/Pt atomic switch structure (2016)

Abstract Redox reactions at the Cu/Ta 2 O 5 interface and subsequent Cu ion transport in a Ta 2 O 5 film have been investigated by means of cyclic voltammetry (CV) measurements. Under positive bias to the Cu electrode, Cu is preferentially oxidized to Cu 2+ and then to Cu + . Subsequent negative bias causes a reduction of the oxidized Cu ions at the interface. It was found that CV curves change drastically with varied relative humidity levels from 5 to 85%. At higher humidity levels, the ion concentrations and diffusion coefficients, estimated from the CV curves, suggest increased redox reaction rates and a significant contribution of proton conduction to the ionic transport. The results indicate that the redox reactions of moisture are rate-limiting and highlight the importance of water uptake by the matrix oxide film in understanding and controlling the resistive switching behavior of oxide-based atomic switches.
Characterization and peripheral blood biomarker assessment of anti–Jo‐1 antibody–positive interstitial lung disease (2009)

In this large cohort of anti-Jo-1 antibody-positive individuals, the incidence of ILD approached 90%. Multiplex ELISA demonstrated disease-specific associations between anti-Jo-1 antibody-positive ILD and serum levels of CRP as well as the interferon-gamma-inducible chemokines CXCL9 and CXCL10, highlighting the potential of this approach to define biologically active molecules contributing to the pathogenesis of myositis-associated ILD.
DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy. (1974)

Summary During intermittent alkylating drug therapy the in vitro myeloma cell thymidine- 3 H-labeling index increases progressively after each treatment course to values as high as 45%. Elevated tumor cell-labeling indices are observed in both responding and nonresponding myeloma patients after cell cycle-nonspecific therapy. In order to determine the mechanism underlying the increased labeling index in treated myeloma patients, we performed autoradiographic studies in which bone marrow cells were incubated with cytosine arabinoside (10 -5 m) or hydroxyurea (10 -3 m) before exposure to thymidine- 3 H. In all five patients studied, incubation of the myeloma cells with either of the S-phasespecific agents resulted in marked inhibition of thymidine- 3 H uptake. These observations indicate that scheduled (prereplicative) and not repair DNA synthesis is the basic mechanism underlying the high labeling indices. The concentrations of cytosine arabinoside and hydroxyurea, which block DNA synthesis by myeloma cells in vitro , are in the range attainable in vivo . Cell cycle-specific antitumor agents could potentially be effective in myeloma patients when the tumor cell-labeling index is elevated after cell cycle-nonspecific therapy.
Growth factor release from tissue engineering scaffolds (2001)

Synthetic scaffold materials are used in tissue engineering for a variety of applications, including physical supports for the creation of functional tissues, protective gels to aid in wound healing and to encapsulate cells for localized hormone-delivery therapies. In order to encourage successful tissue growth, these scaffold materials must incorporate vital growth factors that are released to control their development. A major challenge lies in the requirement for these growth factor delivery mechanisms to mimic the in-vivo release profiles of factors produced during natural tissue morphogenesis or repair. This review highlights some of the major strategies for creating scaffold constructs reported thus far, along with the approaches taken to incorporate growth factors within the materials and the benefits of combining tissue engineering and drug delivery expertise.
Multidimensional Gas Chromatography: Advances in Instrumentation, Chemometrics, and Applications (2017)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMultidimensional Gas Chromatography: Advances in Instrumentation, Chemometrics, and ApplicationsSarah E. Prebihalo†, Kelsey L. Berrier†, Chris E. Freye†, H. Daniel Bahaghighat†‡, Nicholas R. Moore†, David K. Pinkerton†, and Robert E. Synovec*†View Author Information† Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195, United States‡ Department of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, United States*Phone: +1-206-685-2328. Fax: +1-206-685-8665. E-mail: [email protected]Cite this: Anal. Chem. 2018, 90, 1, 505–532Publication Date (Web):October 31, 2017Publication History Published online10 November 2017Published inissue 2 January 2018https://pubs.acs.org/doi/10.1021/acs.analchem.7b04226https://doi.org/10.1021/acs.analchem.7b04226review-articleACS PublicationsCopyright © 2017 American Chemical SocietyRequest reuse permissionsArticle Views4389Altmetric-Citations149LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemometrics,Chromatography,Mathematical methods,Modulators,Volatile organic compounds Get e-Alerts
ChemInform Abstract: Asymmetric Hydrogenation of N‐Tosylimines Catalyzed by BINAP‐Ruthenium( II) Complexes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Centro de Memória IFF - Campus Avançado Maricá: conhecendo, construindo e valorizando nossas memórias (2018)

Implantando no campus avancado Marica em 2016, o Centro de Memoria objetiva, por meio do (re) conhecimento e da pesquisa sobre a historia e as memorias locais, a aproximacao entre a comunidade academica e a populacao maricaense. A metodologia do projeto contempla duas frentes de acao. No âmbito interno ao Instituto Federal, trabalha-se pela construcao da memoria institucional sobre a implantacao do campus do IFFluminense em Marica, ainda abrigado em sede provisoria. No plano propriamente extensionista, dedica-se a acoes de valorizacao do patrimonio historico e cultural de Marica, em parceria com orgaos da administracao municipal. Com nova composicao de bolsistas, o Centro de Memoria apresenta, neste Encontro de Cultura do IFFluminense, uma sintese dos resultados alcancados nos dois primeiros anos de trabalho, as acoes ora em curso e as perspectivas do projeto para os proximos meses.
Alkylboronate β‐Phenylglucoside versus Phenylboronate β‐Alkylglucoside Organogelators (2023)

Abstract Low molecular weight organogelators provide useful materials which have already found applications in various fields. Recently, phenylboronate alkylglucosides have become new members of this type of organogelators providing water‐sensitive gels. This work is focused on the impact of the position of alkyl and phenyl moieties within this type of structures. Thus, alkylboronate phenylglucoside and alkylboronate alkylglucoside counterparts were synthesized and studied. Organogels obtained in toluene and ethyl myristate were characterized by rheology and electron microscopy. In addition, we also determined the disruption rates of such organogels upon addition of a small amount of water. Alkylboronate alkylglucosides did not induce gelation of the tested solvents but all derivatives bearing a phenyl ring either on the boronate function or on the glucoside unit came out as good organogelators. However, alkylboronates were found to have higher water sensitivities than phenyl counterparts. Thus, this work has enlarged the scope of glucoside‐boronate organogelators and their water sensitivity which can represent useful materials in drug delivery systems for example.
Covalent chemical modification of self- assembled fluorocarbon monolayers by low- energy CH2Br2+· ions: a combined ion/surface scattering and X-ray photoelectron spectroscopic investigation (1999)

Specific covalent chemical modification at the outermost atomic layers of fluorinated self-assembled monolayers (F-SAMs) on gold is achieved by bombardment with low-energy polyatomic ions (<100 eV). The projectile ion CH2Br2+· (m/z 172), mass and energy selected using a hybrid ion/surface scattering mass spectrometer and scattered from the F-SAM surface, CF3(CF2)7(CH2)2-S-Au, undergoes ion/surface reactions evident from the nature of the scattered ions, CH2F+ (m/z 33), CHBrF+ (m/z 111), and CF2Br+ (m/z 129). The chemical transformation of the reactive F-SAM surface was independently monitored by in situ chemical sputtering with the projectile Xe+·. Representative species sputtered from the modified surface include CF2Br+, an indicator of terminal CF3 to CF2Br conversion. X-ray photoelectron spectroscopy (XPS) was used to confirm the presence of organic bromine at the surface; Br (3P3/2) and Br (3P1/2) peaks were present at binding energies of 182 and 190 eV, respectively. XPS analysis also revealed increased surface modification at higher collision energies in these reactive ion bombardment experiments, as exemplified by the increased hydrocarbon/fluorocarbon peak ratio in the C(1s) region and incorporation of oxygen in the surface seen in the observation of an O(1s) peak. Copyright © 1999 John Wiley & Sons, Ltd.
Up-regulated Circular RNAs in Colorectal Cancer: New Entities for Therapy and Tools for Identification of Therapeutic Targets (2023)

Patients with disseminated colorectal cancer have a dismal prognosis with a 5-year survival rate of only 13%. In order to identify new treatment modalities and new targets, we searched the literature for up-regulated circular RNAs in colorectal cancer which induce tumor growth in corresponding preclinical in vivo models. We identified nine circular RNAs that mediate resistance against chemotherapeutic agents, seven that up-regulate transmembrane receptors, five that induce secreted factors, nine that activate signaling components, five which up-regulate enzymes, six which activate actin-related proteins, six which induce transcription factors and two which up-regulate the MUSASHI family of RNA binding proteins. All of the circular RNAs discussed in this paper induce the corresponding targets by sponging microRNAs (miRs) and can be inhibited by RNAi or shRNA in vitro and in xenograft models. We have focused on circular RNAs with demonstrated activity in preclinical in vivo models because the latter is an important milestone in drug development. All circular RNAs with in vitro activity only data are not referenced in this review. The translational impact of inhibition of these circular RNAs and of the identified targets for treatment of colorectal cancer (CRC) are discussed.