gebhart/patrepeval huggingface dataset:
Detection of Dose Response in Chronic Doxorubicin-Mediated Cell Death with Cardiac Technetium 99m Annexin V Single-Photon Emission Computed Tomography (2008)

The aim of this study was to evaluate whether technetium 99m hydrazinonicotinamide (99mTc-HYNIC)-annexin V single-photon emission computed tomography (SPECT) would detect dose-dependent doxorubicin (DOX)-mediated cell death in the heart compared with functional echocardiography. Adult female Sprague-Dawley rats were treated with DOX (cumulative dose of 15 or 7.5 mg/kg) or saline (n = 7) and monitored by echocardiography. Rats were injected with 7 to 8 mCi 99mTc-HYNIC-annexin V and imaged 1 hour postinjection using a small animal dual-head SPECT/computed tomography (CT) system with multipinhole technology. Two regions of interest were drawn in the myocardium and soft tissue regions to calculate the cardiac uptake ratio (CUR) of reconstructed images. Myocardium and blood were harvested for radioactivity measurements or TUNEL assay. Biodistribution of 99mTc-HYNIC-annexin V uptake, CUR from SPECT/CT fused cardiac images, and TUNEL of myocardium demonstrated a dose-dependent toxicity response, with the cumulative 15 mg/kg DOX treatment showing the greatest degree of cell death. In contrast, echocardiography detected functional deficits only at the highest DOX dose. In vivo molecular imaging of DOX-induced cardiac toxicity with 99mTc-HYNIC-annexin V detects dose-dependent cell death before ventricular deficits are observed with echocardiography. 99mTc-HYNIC-annexin V SPECT-based molecular imaging may provide an attractive new technique for assessing early changes in myocardial function in patients undergoing DOX therapy.
Cloaking of Equilateral Triangle Patch Antennas and Antenna Arrays with Planar Coated Metasurfaces (2023)

In this paper, we have proposed an effective metasurface design to accomplish cloaking of equilateral patch antennas and their array configuration. As such, we have exploited the concept of electromagnetic invisibility, employing the mantle cloaking technique with the intention to eliminate the destructive interference ensuing between two distinct triangular patches situated in a very congested arrangement (sub-wavelength separation is maintained between the patch elements). Basically, we demonstrate that implementation of the planar coated metasurface cloaks onto the patch antenna surfaces compels them to become invisible to each other, at the intended frequencies. In effect, an individual antenna element does not sense the presence of the other, in spite of being in a rather close vicinity. We also exhibit that the cloaks successfully reinstate the radiation attributes of each antenna in such a way that it emulates their respective performance in an isolated environment. Moreover, we have extended the cloak design to an interleaved one dimensional array of the two patch antennas and it is shown that the coated metasurfaces assure efficient performance of each array in terms of their matching as well as radiation characteristics, in turn, enabling them to radiate independently for various beam-scanning angles.
Abstract 1157: Screening and identification of new generation glucose transporter inhibitors as anticancer therapeutics (2017)

Abstract Cancer is a top killer second only to cardiovascular diseases. Cellular metabolic reprogramming and altered energetics are key features of cancer. Opportunistic uptake of extracellular nutrients has recently been named as an emerging hallmark of cancer metabolism. Glucose is a key nutrient taken in by cancer cells for satisfying their high energy and biosynthesis needs. Drastic upregulation of glucose uptake and glycolytic activity, a phenomenon called the Warburg effect, is prevalent in cancers. Cancer cells overexpress specific glucose transporters (Gluts), particularly Glut1, on cell membranes for taking in glucose via facilitated diffusion. Considering the addiction of cancer cells for glucose and their sensitivity and vulnerability to changes in glucose supply, Gluts, especially Glut1, have been recognized as an attractive anticancer target. We previously reported the identification of first generation lead Glut1 inhibitor WZB117 (1). WZB117 treatment of human nonsmall cell lung cancer (NSCLC) A549 cells resulted in inhibition of glucose uptake, glycolysis and induction of apoptosis and necrosis. In addition, WZB-117 reduced tumor growth by ~70% in an A549 tumor mouse model. WZB117 inhibit cell growth of 7 cancer cell lines in 4 cancer types with IC50 values lower than 10 μM. Through a structure activity relationship (SAR) study of WZB117, a second generation lead, DRB18, has been identified. DRB-18 is much more stable and 5 to 10 times more potent than WZB117 in inhibiting growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types as revealed in NCI-60 screenings. And its IC50s in many cancer cell lines are in the high nM range. In this study, we also report new compounds screening results for the objective of identifying novel compounds with higher glucose transport-inhibitory and cancer cell growth-inhibitory activities using nonsmall cell lung cancer cell lines as models. References: 1. Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qian, Y., Akbar, H., Colvin, R., Ding, J., Tong, L., Wu, S. and Hines, J., 2012. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Molecular cancer therapeutics, 11(8):1672-1682. Citation Format: Yanrong Qian, Pratik Shriwas, Xuan Wang, Dennis Roberts, Emma Kessler, Stephen Bergmeier, Xiaozhuo Chen. Screening and identification of new generation glucose transporter inhibitors as anticancer therapeutics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1157. doi:10.1158/1538-7445.AM2017-1157
Pyrolytic carbon electrodes: Small 24/2009 (2009)

The cover picture shows lithographically defined porous carbon electrodes created using interferometric lithography to make 3D periodic structures in photoresist that are converted to conducting carbon via pyrolysis. The structures undergo significant shrinkage but maintain their pattern morphology and adhesion to the substrate. The porous electrodes contain five patterned layers and engineered structures covering seven orders of magnitude in size scale. Electrochemical deposition of 1–3-nm gold nanoparticles and catalytic activity towards methanol oxidation following electroless palladium deposition onto the porous carbon lattice show promise for these structures as a highly adaptable electrode material. For more information, please read the Communication “Lithographically Defined Porous Carbon Electrodes” by D. B. Burckel, R. Polsky, et al., beginning on page 2792.
Encapsulation of α-Particle–Emitting225Ac3+Ions Within Carbon Nanotubes (2015)

US-tubes successfully sequester (225)Ac(3+) ions in the presence of Gd(3+) ions and retain them after a human serum challenge, rendering (225)Ac@GNTs candidates for radioimmunotherapy for delivery of (225)Ac(3+) ions at higher concentrations than is currently possible for traditional ligand carriers.
Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen (2001)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of Estrogen Sulfotransferase Inhibitors from a Purine Library ScreenDawn E. Verdugo, Mark T. Cancilla, Xue Ge, Nathanael S. Gray, Young-Tae Chang, Peter G. Schultz, Masahiko Negishi, Julie A. Leary, and Carolyn R. BertozziView Author Information Center for New Directions in Organic Synthesis, Howard Hughes Medical Institute, and Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720, Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, Suite 200, San Diego, California 92121, Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, and Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003 Cite this: J. Med. Chem. 2001, 44, 17, 2683–2686Publication Date (Web):July 17, 2001Publication History Received18 April 2001Published online17 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/jm010171uhttps://doi.org/10.1021/jm010171urapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views862Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Assays,Inhibition,Inhibitors,Peptides and proteins Get e-Alerts
Quantitative & qualitative evaluation of accelerated T2 mapping technique using Deep Learning reconstruction in knee cartilage (2023)

MRI-based cartilage imaging shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI and arthroscopy. However, clinical application of T2 mapping is driven by high variability and suboptimal reproducibility, besides long examination times. The purpose of this study is to accelerate T2 mapping technique and apply a novel DL reconstruction method to develop a fast and robust way to access T2 relaxometry. Phantom and in-vivo testing demonstrated that DL reconstructed accelerated images provide increased consistency compared to conventional reconstruction and implies a great step into an extensive clinical adoption.
A new maneuvering target tracking algorithm with input estimation (2003)

A new tracking algorithm is proposed. It treats the target acceleration as a nonrandom term, and consists of a constant velocity filter an input estimator and a maneuver detector implemented in parallel. The new method has the same advantages as the two-stage Kalman estimator which requires a lesser amount of computation and provides even a better performance when compared with an augmented state Kalman filter. At the same time, the new method uses a better tuning parameter and removes a difficulty in implementation of the two-stage Kalman estimator. It is shown that the new filter is a better alternative to the two-stage Kalman estimator on tracking maneuvering targets.
Supported organoactinides. Surface chemistry and catalytic properties of alumina-bound cyclopentadienyl and pentamethylcyclopentadienyl thorium and uranium hydrocarbyls and hydrides (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSupported organoactinides. Surface chemistry and catalytic properties of alumina-bound cyclopentadienyl and pentamethylcyclopentadienyl thorium and uranium hydrocarbyls and hydridesMing Yuan He, Guoxing Xiong, Paul J. Toscano, Robert L. Burwell Jr., and Tobin J. MarksCite this: J. Am. Chem. Soc. 1985, 107, 3, 641–652Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://doi.org/10.1021/ja00289a016RIGHTS & PERMISSIONSArticle Views351Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Dry heat sterilization as a method to recycle N95 respirator masks: the importance of fit (2021)

Abstract In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators, are disrupted. To combat shortages of N95 respirators, many institutions were forced to decontaminate and reuse respirators. While several reports have evaluated the impact on filtration as a measurement of preservation of respirator function after decontamination, the equally important fact of maintaining proper fit to the users’ face has been understudied. In the current study, we demonstrate the complete inactivation of SARS-CoV-2 and preservation of fit test performance of N95 respirators following treatment with dry heat. We apply scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), X-ray diffraction (XRD) measurements, Raman spectroscopy, and contact angle measurements to analyze filter material changes as a consequence of different decontamination treatments. We further compared the integrity of the respirator after autoclaving versus dry heat treatment via quantitative fit testing and found that autoclaving, but not dry heat, causes the fit of the respirator onto the users face to fail, thereby rendering the decontaminated respirator unusable. Our findings highlight the importance to account for both efficacy of disinfection and mask fit when reprocessing respirators to for clinical redeployment.
Angular momentum dependence of the twist-induced effect in few-mode fibres (2016)

The twist-induced effect on fibre modes has been recognized as a phase shift depending on the total angular momentum. The amount of this phase shift has been measured through an interference experiment in a few-mode fibre, confirming the theoretical predictions.
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. (1995)

A combination of transient kinetic and equilibrium titration methods has been used to show that both primer/template and nucleotide binding to human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are two-step processes. In both cases, after initial formation of relatively weakly bound states, isomerization reactions lead to tightly bound states. In the case of deoxynucleotide binding to the reverse transcriptase-primer/template complex, the second step in the interaction is rate-limiting in the overall reaction during processive polymerization. Discrimination against incorrect nucleotides occurs both in the initial weak binding and in the second step but is purely kinetic in the second step (as opposed to thermodynamic in the first step). Nonnucleoside inhibitors have a relatively small effect on nucleotide-binding steps (overall affinity is reduced by a factor of ca. 10), while the affinity of the primer/template duplex is increased by at least a factor of 10. The major effect of nonnucleoside inhibitors is on the chemical step (nucleotide transfer).
Novel, Trimeric Mn-Substituted Undecatungstosilicate, [(β2-SiW11MnO38OH)3]15- (2001)

The novel, Mn-substituted undecatungstosilicate [(β2-SiW11MnO38OH)3]15- (1) has been characterized by IR spectroscopy, elemental analysis, and single-crystal X-ray diffraction. Anion 1 is composed of three [β2-SiW11MnO38OH]5- fragments linked via three Mn−O−W (145(1)°) bridges leading to a triangular, chiral entity. The two enantiomers of 1 are present in a ratio of 3:2 in the crystal studied.
Capacitive Lamé mode resonator with gap closing mechanism for motional resistance reduction (2017)

This work presents a Lamé mode resonator featuring a novel gap closing mechanism which employs electrostatic force to reduce the capacitive transduction gaps to sub-micron values to overcome fabrication technology limitations. This leads to significant resonator loss and motional resistance reduction, which is highly advantageous as it simplifies the design of oscillation sustaining circuitry. Prototypes were fabricated in a commercial silicon-on-insulator technology, PiezoMUMPs from MEMSCAP. Upon the application of a DC voltage of 55 V between the resonator structure and electrodes, the gaps are reduced from 2.5 μm to 0.5 μm. A resonance frequency of 18 MHz with a quality factor of 120,000 was observed under 1 mTorr vacuum. A loss of 55 dB was measured at 55 V, which corresponds to a motional resistance of 56 kΩ, 5 times lower than that of a similar design without gap closers at the same voltage. The frequency tuning range is also increased significantly as a result of the gap reduction, which can be very useful for overcoming ambient conditions and fabrication variations.
ChemInform Abstract: Preparative‐Scale Matrix Isolation: Application to the Direct Synthesis of Binary Metal Carbonyls Using Metal Atomic Reagents. (1986)

Abstract The cocondensation of the monoatomic vapors of V, Cr, Mn, Fe, and Ru with CO (25‐30 K) to yield Ru(CO) 5 , Ru 3 (CO) 12 , Mn 2 (CO) 10 , V(CO) 6 , Cr(CO) 6 , and Fe 3 (CO) 12 is described.
Consequences of the expression of a bacterial glucokinase in potato tubers, both in combination with and independently of a yeast-derived invertase (2000)

This paper originates from a presentation at the International Conference on Assimilate Transport and Partitioning, Newcastle, NSW, August 1999 The aim of this work was to further define the metabolic factors that regulate carbohydrate metabolism in potato ( Solanum tuberosum L. cv. Desiree) tubers. We previously found that glycolysis is induced (and starch accumulation reduced) in transgenic tubers in which a yeast invertase and a glucokinase from Zymomonas mobilis were expressed in the cytosol, whereas potato tuber size is dramatically increased when invertase expression is targeted to the apoplast. In this study we describe the further characterisation of potato tubers expressing a yeast invertase in the apoplast. We also report the generation of two novel transgenic plants in which the Z. mobilis glucokinase gene is expressed tuber-specifically (either in the wild type or apoplastic invertase-expressing back-ground). We evaluated the influence that increasing the glucokinase activity, independent of invertase activity, had on the shift in carbon partitioning, and assessed if the hexoses produced by the apoplastic cleavage of sucrose could be brought into metabolism. We found that expression of glucokinase either in the wild type or in the apoplastic invertase-expressing background led to changes in the levels of glucose and glucose 6-phosphate. However, these changes had little effect on carbon partitioning or tuber size with respect to the parent line. We conclude that neither the accumulation nor the phosphorylation of glucose play a pivotal role in the regulation of metabolism or morphology in the potato tuber.
Synteny and Collinearity in Plant Genomes (2008)

Correlated gene arrangements among taxa provide a valuable framework for inference of shared ancestry of genes and for the utilization of findings from model organisms to study less-well-understood systems. In angiosperms, comparisons of gene arrangements are complicated by recurring polyploidy and extensive genome rearrangement. New genome sequences and improved analytical approaches are clarifying angiosperm evolution and revealing patterns of differential gene loss after genome duplication and differential gene retention associated with evolution of some morphological complexity. Because of variability in DNA substitution rates among taxa and genes, deviation from collinearity might be a more reliable phylogenetic character.
Physiological basis of differential phytotoxic activity between fenoxaprop‐P‐ethyl and cyhalofop‐butyl‐treated barnyardgrass (2005)

This study investigated the physiological causes of differences in phytotoxic symptoms shown in barnyardgrass from foliar applications of the herbicides fenoxaprop‐P‐ethyl and cyhalofop‐butyl. When these were applied to the third leaves of the whole plant, the chlorosis and desiccation in the third leaf was greater in fenoxaprop‐P‐ethyl than cyhalofop‐butyl. However, initial growth inhibition of the fourth leaf was greater when using cyhalofop‐butyl than when using fenoxaprop‐P‐ethyl. In the shoot regrowth test, regrowth at five days after treatment (DAT) was smaller in cyhalofop‐butyl than in fenoxaprop‐P‐ethyl; the regrowth at 10 DAT exhibited the reverse trend. The chlorosis (decrease of chlorophylls: carotenoids ratio) in barnyardgrass leaf segments that were floated on herbicide solution was greater in the fenoxaprop‐P‐ethyl treatment. These results indicate that different herbicidal responses induced by the two herbicides are likely to be related to differential translocation and metabolism. The relatively light chlorosis and desiccation in treated leaves, severe cessation of initial growth (but a lower final herbicidal efficacy in the cyhalofop‐butyl treatment) are probably related to its rapid translocation to the meristem region from the treated leaf, followed by faster metabolism. In contrast, the relatively greater chlorosis and desiccation compared to inhibition of initial growth in the fenoxaprop‐P‐ethyl treatment is likely to be related to its relatively slower translocation and metabolism in the treated leaf.
4-PAM visible light communications with a XOR-tree digital silicon photomultiplier (2015)

We show reception of a higher order modulation scheme using a novel high-fill-factor XOR-tree based digital silicon photomultiplier array. We also demonstrate and model even-order XOR cancellation and nonlinear saturation resulting from this design.
Mini direction-finding gamma spectrometer (Conference Presentation) (2019)

Inexpensive spectroscopic personal radiation detectors (SPRDs) are needed to monitor environmental radioactivity and search for sources. For gamma spectroscopy, excellent light yield, material uniformity, light yield proportionality, mechanical and environmental ruggedness can be achieved in polycrystalline ceramic oxide garnets. We are building a compact detector based on 14 cm3 of transparent ceramic garnet, formed into 256 pixels (3mm x 3mm x 6mm each) and mounted on two stacked silicon photodiode arrays. GYGAG(Ce) garnet transparent ceramics offer density = 5.8g/cm3, Zeff = 48, principal decay of <100 ns, and light yield of 50,000 Ph/MeV. We obtain R(662 keV) <4% for the full device, including Compton summing of coincident events in multiple pixels. In addition to excellent gamma spectroscopy, this device provides directional detection, via Compton imaging and active masking, for search applications. This work was performed under the auspices of the U.S. DOE by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. We are grateful to Digirad for supporting our implementation of their photodiode array. Thanks to the US Department of Homeland Security, DNDO and CWMD offices, for funding under competitively awarded IAAs HSHQDC-12-X-00149 and HSHQDN-17-X-00016.