MP36-18 EARLY ONSET DIABETES MELLITUS CORRELATES WITH COMPLICATIONS OF PEYRONIE'S DISEASE (2023)

You have accessJournal of UrologyCME1 Apr 2023MP36-18 EARLY ONSET DIABETES MELLITUS CORRELATES WITH COMPLICATIONS OF PEYRONIE'S DISEASE Serkan Karakus, Xi (Daisy) Dai, Selman Unal, Crystal Joseph, Jason Levy, William Ducomb, Dorota Hawksworth, and Arthur L. Burnett Serkan KarakusSerkan Karakus More articles by this author , Xi (Daisy) DaiXi (Daisy) Dai More articles by this author , Selman UnalSelman Unal More articles by this author , Crystal JosephCrystal Joseph More articles by this author , Jason LevyJason Levy More articles by this author , William DucombWilliam Ducomb More articles by this author , Dorota HawksworthDorota Hawksworth More articles by this author , and Arthur L. BurnettArthur L. Burnett More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003270.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by an abnormality in the collagen structure of the penile tunica albuginea resulting in plaque formation and penile deformity. The prevalence of PD is estimated to be 3.2-8.9% overall and as high as 20.3% in men with diabetes mellitus (DM). However, the impact of DM on PD complications is unclear. We aimed to investigate clinical correlations between DM characteristics and PD complications. METHODS: We performed a retrospective study of patients with DM and PD presenting to our institution between 2007 and 2022. Clinical history, clinical parameters of DM, and PD complications were analyzed. Penile deformities were determined by physical exam, photographs, and penile Doppler ultrasound. Patients were divided into subgroups according to the onset of DM as early (<45 years old), average (45-65 years old), and late (>65 years old). RESULTS: A total of 185 patients were evaluated. Data collection parameters are shown in Table 1. Early onset DM correlated with the early development of PD (rho=0.52, p<0.001). Also, early onset DM correlated with the formation of penile plaque (rho=-0.18, p=0.03) and larger plaque size (rho=-0.35, p=0.03). An increase in HbA1c level after the initial diagnosis of PD positively correlated with the formation of penile plaque (rho=0.24, p=0.03) and penile deformity (rho= 0.24, p=0.049). CONCLUSIONS: Our study suggested that early onset DM and a further increase in HbA1c levels after the PD diagnosis significantly impact the severity of PD. Revealing the mechanisms behind these findings will help us develop better management strategies in diabetic PD patients. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e486 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Serkan Karakus More articles by this author Xi (Daisy) Dai More articles by this author Selman Unal More articles by this author Crystal Joseph More articles by this author Jason Levy More articles by this author William Ducomb More articles by this author Dorota Hawksworth More articles by this author Arthur L. Burnett More articles by this author Expand All Advertisement PDF downloadLoading ...