gebhart/patrepeval huggingface dataset:
Salt loading enhances rat renal TxA2/PGH2receptor expression and TGF response to U-46,619 (1997)

The tubuloglomerular feedback (TGF) response is potentiated by thromboxane A2 (TxA2) and/or prostaglandin endoperoxide (PGH2) acting on specific receptors. Infusion of the TxA2/PGH2 mimetic, U-46,619, into conscious rats leads to hypertension that is potentiated by a high-salt intake. Therefore, we tested the hypothesis that a high-salt intake enhances the expression of transcripts for TxA2/PGH2 receptors in the kidney and glomeruli and enhances the response of TGF to TxA2/PGH2 receptor stimulation. Groups of rats were accommodated to a low-salt (LS), normal salt (NS), or high-salt (HS) diet for 8-10 days. TxA2/PGH2 receptor mRNA was detected by reverse transcription-polymerase chain reaction in kidney cortex, isolated glomeruli, and abdominal aorta. TxA2/PGH2 mRNA abundance was significantly (P < 0.001) increased during intake of high-salt compared with low-salt diets in the kidney cortex (1.34 +/- 0.10 vs. 0.84 +/- 0.04 arbitrary units) and isolated outer cortical glomeruli (0.68 +/- 0.04 vs. 0.32 +/- 0.03 arbitrary units), but there was no effect of salt on TxA2/PGH2 receptor mRNA expression in the aorta. Maximal TGF responses were assessed from the increase in proximal stop flow pressure (an index of glomerular capillary pressure) during increases in loop of Henle perfusion with artificial tubular fluid from 0 to 40 nl/min. Compared with vehicle, the enhancement of maximal TGF with U-46,619 (10(-6) M) added to the perfusate was greater in rats adapted to high-salt than normal salt (HS: +9.6 +/- 1.1 vs. NS: +5.1 +/- 0.4 mmHg; P < 0.001) or low-salt (LS: +3.8 +/- 1.3 mmHg; P < 0.001) intakes. Responses to U-46,619 at each level of salt intake were blocked by > 70% by the TxA2/PGH2 receptor antagonist ifetroban. In contrast, enhancement of TGF by peritubular capillary perfusion of arginine vasopressin (AVP; 10(-7) M) was similar in high-salt and low-salt rats (HS: +1.5 +/- 0.6 vs. LS: +1.6 +/- 0.5 mmHg; not significant). We conclude that salt loading increases selectively the abundance of TxA2/PGH2 receptor transcripts in the kidney cortex and glomerulus, relative to the aorta, and enhances selectively TGF responses to TxA2/PGH2 receptor activation but not to AVP.
Crystal structure of Bis(N,N-diethyldithiocarbamato)(isothiocyanato)iron(III) (1980)

The crystal structure of the title compound [Fe(NCS)(S2CNEt2)2] has been determined by single-crystal X-ray diffraction methods at 295(1) K and refined to a residual of 0.054 for 998 'observed' reflections. Crystals are orthorhombic, P212121, with a 18.70(2), b 15.43(2), c 6.667(6)?, Z 4. The iron atom of the complex molecule [Fe(NCS)(S2CNEt2)2] is five- coordinated, being bonded by four sulfur atoms [Fe-S, 2.257-2.300(5) ?] and the nitrogen atom of the thiocyanate [Fe-N, 1.91(2)?].
Scintillation Properties of Nd-doped LuVO4 Single Crystals (2022)

Nd-doped LuVO 4 single crystals were synthesized by the floating zone method and their optical properties including scintillation were evaluated. The synthesized Nd-doped LuVO 4 samples had a LuVO 4 single phase. The 1.0% Nd-doped LuVO 4 had the highest photoluminescence (PL) quantum yield (87%) of all the samples in the NIR range. The Nddoped LuVO 4 samples showed scintillation peaks around 900, 1060, and 1320 nm due to the electronic transition of Nd 3+ . Moreover, there was a strong correlation between the scintillation signal intensity and the X-ray exposure dose rate in the wavelength range from 900 to 1600 nm, and all the samples showed good linearity with a dynamic range from 0.006 to 60 Gy/h.
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma (2011)

Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene [encoding far-upstream element (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.
A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis (1983)

Macrolide-lincosamide-streptogramin B resistance specified by Streptococcus sanguis plasmid pAM77 involves an adenine methylase, whose synthesis, demonstrable both phenotypically and by analysis of methionine-labeled proteins made in Bacillus subtilis minicells, is inducible by erythromycin, lincomycin, and streptogramin type B antibiotics. Localization of the methylase structural gene, including its control region in DNA fragments obtained with restriction endonucleases, has been deduced from DNA blot experiments with characterized target and probe DNAs from other streptococci, combined with DNA sequence analysis and comparison of the putative streptococcal methylase sequence with that of a cognate methylase in staphylococcal plasmid pE194. The streptococcal methylase migrates electrophoretically in polyacrylamide gels with the mobility of a 29,000-dalton protein. The sequence organization of the putative streptococcal methylase mRNA leader sequence partially resembles its staphylococcal counterpart and can support a similar mechanism of secondary structure rearrangement leading to methylase synthesis. The deduced 5' leader sequence preceding the pAM77 methylase structural gene sequence comprises approximately 155 nucleotides within which one can identify a putative control peptide 36 amino acid residues in length (in contrast to 19 in the pE194 peptide) and at least 14 possible classes of overlapping inverted complementary repeat sequences (in contrast to 3 in the pE194 control region), one of which can sequester the sequence AGGAG 7 nucleotides upstream from the putative (methionine) start codon of the streptococcal methylase. Comparison of the pAM77 and pE194 methylase amino acid sequences and their respective nucleotide sequences shows 51% conservation of amino acid residues (124 of 244) and 59% conservation of nucleotide residues (433 of 738), which suggests a common origin for the two methylase structural gene sequences. Differences in mRNA base composition associated with conserved amino acid residues occur mostly in the third nucleotide ("wobble") position of codons and may reflect adaptation of methylase genes to optimal expression in host cells with differing codon use patterns.
Clinical utility of repurposing a short course of hepatitis C drugs for COVID19. A randomized controlled study (2022)

ABSTRACT BACKGROUND Preliminary data suggests a potential therapeutic benefit for the hepatitis C drugs, sofosbuvir (SOF) and daclatasvir (DCV) for the treatment of COVID-19. We aim to evaluate efficacy of a short course of dual sofosbuvir/daclatasvir in patients with COVID-19. METHODS Eighty-nine consecutive eligible patients were randomly assigned to two treatment groups. The experimental group was treated with the standard of care (SOC) therapy in addition to one 400 mg tablet sofosbuvir and one 60 mg daclatasvir daily for 10 days; while the control group was treated with the SOC therapy alone. Baseline clinical data was measured and followed up for 21 days. Data was compared between the two treatment groups. RESULTS The proportion of cumulative clinical recovery in the experimental group at day 21 was numerically greater than the control group (40/44 (91%; 95%CI: 78.8-96.4%) versus 35/45 (77.8%; CI 63.7-87.5%)). The Hazard Ratio (HR) for time to clinical recovery adjusted for baseline severity, using a Cox-regression model was statistically significant: HR: 1.59 (95%CI: 1.001-2.5). Concordantly, the experimental group also showed trends for greater improvement in the mean 8-points ordinal scale score, the severity of lung lesions score and the case fatality rate (4.5% versus 11.1%). No serious or severe adverse events were reported in both groups. CONCLUSION This study supports potential benefit and safety of sofosbuvir combined with daclatasvir when given early in the treatment of COVID-19. We hope to encourage further large sized, multinational studies to confirm the results. HIGHLIGHTS Preliminary data suggests a potential therapeutic benefit for the hepatitis C drugs, sofosbuvir (SOF) and daclatasvir (DCV) for the treatment of COVID-19. Eighty-nine COVID-19 patients were randomly assigned to either treatment with SOC plus a short course of combined SOF/DCV therapy or SOC therapy alone. The Hazard Ratio (HR) for time to clinical recovery adjusted for baseline severity showed statistical significance: HR: 1.59 (95%CI: 1.001-2.5). Concordantly, all other efficacy endpoints showed numerical trends for greater improvement in the experimental group including the case fatality rate (4.5% versus 11.1%). No serious or severe adverse events were reported in both groups. SOF/DCV therapy might be beneficial when given early in the treatment of COVID-19.
Crystallization and Melting in Compatible Polymer Blends (1985)

Some of the important aspects concerning crystallization and melting in semicrystalline, compatible polymer blends are reviewed. Crystallization in these systems is governed by a variety of factors, and crystallization rates both decrease and increase upon diluting the crystallizable species. Spherulitic growth rates are frequently analyzed via a modified Turnbull and Fisher approach, and the good correlation of experimental data indicates that the dependence of growth rate on temperature is quite similar to pure crystalline polymers. Analysis of the equilibrium melting point depression in these blends provides an estimate of the magnitude of the polymer-polymer interactions (χ). Direct use of experimental melting points in the expression describing melting point depression can potentially result in a serious underestimation of χ.
A Model to Explain the Therapeutic Effects of Serotonin Reuptake Inhibitors: The Role of 5-HT2 Receptors (2025)

In this article, it is posited that major depression involves an underfunctioning dopamine system resulting from hypersensitive inhibitory 5-HT2 receptors located on dopaminergic neurons. After a few weeks, treatment with most antidepressant drugs leads to a downregulation of the 5-HT2 receptors that allows for increased dopaminergic firing, which is proposed to be decisive for the antidepressant effect. However, serotonin reuptake inhibitors (SRIs) therapeutic mechanisms probably differ between different therapeutic outcomes. It is hypothesized, that in women, the use of female sex steroids leads to a downregulation of 5-HT2C receptors that contributes to atypical depressive symptoms and premenstrual dysphoria. Consequently, these conditions can be assumed to benefit from the acute increase of serotonergic neurotransmission following ingestion of an SRI rather than the secondary receptor changes, which would explain why there is a therapeutic lag time when SRIs are used to treat depression but not premenstrual dysphoric disorder. The clinical predictions derived from this hypothesis are that 5-HT2 antagonists would be an effective treatment in melancholic depression, have a fast onset of action, speed the onset of SRIs, and can be an effective augmentation for SRI-refractory patients. In contrast, in atypical depression and premenstrual dysphoria a 5-HT2 antagonist would counteract the therapeutic effect of an SRI, while 5-HT2 agonists have a therapeutic potential. It is suggested that therapeutic response to 5-HT2 antagonists/agonists may be used as a diagnostic tool to dissect subgroups of depression.
[Cytotoxic and antitumor activity of a new series of heterocyclic compounds: dipyrido (4,3-b) (3,4-f) indoles]. (1977)

Among newly synthesized compounds derived from the dipyrido [4,3-b] [3,4-f] indole nucleus, two have proved to be particularly active in vitro and in vivo. Their cytotoxic effects on cultured cells have been determined. At non toxic doses, they displayed a pronounced inhibitory effect on experimental L1210 Leukemia. These compounds have a strong affinity for DNA molecules.
Hydrogenation of Aqueous Acetic Acid over Ru-Sn/TiO2 Catalyst in a Flow-Type Reactor, Governed by Reverse Reaction (2020)

Ru-Sn/TiO2 is an effective catalyst for hydrogenation of aqueous acetic acid to ethanol. In this paper, a similar hydrogenation process was investigated in a flow-type rather than a batch-type reactor. The optimum temperature was 170 °C for the batch-type reactor because of gas production at higher temperatures; however, for the flow-type reactor, the ethanol yield increased with reaction temperature up to 280 °C and then decreased sharply above 300 °C, owing to an increase in the acetic acid recovery rate. The selectivity for ethanol formation was improved over the batch process, and an ethanol yield of 98 mol % was achieved for a 6.7 min reaction (cf. 12 h for batch) (liquid hourly space velocity: 1.23 h−1). Oxidation of ethanol to acetic acid (i.e., the reverse reaction) adversely affected the hydrogenation. On the basis of these results, hydrogenation mechanisms that include competing side reactions are discussed in relation to the reactor type. These results will help the development of more efficient catalytic procedures. This method was also effectively applied to hydrogenation of lactic acid to propane-1,2-diol.
Alkoxy-substituted poly(diarylsilanes): thermochromism and solvatochromism (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkoxy-substituted poly(diarylsilanes): thermochromism and solvatochromismR. D. Miller and R. SooriyakumaranCite this: Macromolecules 1988, 21, 10, 3120–3122Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ma00188a038https://doi.org/10.1021/ma00188a038research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PP.LB02.02 (2015)

Objective: Alpha-isocubebene (α-ICB) is a compound isolated from Schisandra chinensis fruit which is a well-known as a useful material in the preventive or treatment of cardiovascular symptoms in Korean. Design and method: In the present study, the vasoactivities of α-ICB were evaluated in the isolated thoracic aorta of mice (8-week-old male C57/BL6). Results: In isolated rings of aorta (about 2 mm in width), phenylephrine (0.1–3.0 μM), adrenergic α-receptor agonist, or norepinephrine (10–300 nM) induced vasocontraction in dose-dependent manners, which were markedly attenuated by α-ICB (1–10 μg/ml) in a concentration-dependent manner. However, α-ICB had no effects on vasodilation induced by acetylcholine (10–300 nM). These results suggested that α-ICB regulated vasocontraction via regulation of contractile machine including myosin light chain (MLC) on the vasculature. In the immunoblot analysis, α-ICB inhibited phosphorylation of MLC at the sites of Thr18 and Thr18/Ser19. The effects on Thr18 phosphorylation were more prominent than that at The18/Ser19 sites, suggesting a pivotal involvement of MLC phosphatase in the modulation of vasocontraction by α-ICB. Conclusions: Collectively, α-ICB attenuated vasocontraction induced by various agonists through inhibition of MLC phosphorylation via an increased activity of MLC phosphatase.
Broadband, miniaturized stacked-patch antenna based on magneto-dielectric substrates for L-band operation (2009)

In this paper, the use of magneto-dielectric layers will be extended to the application of stacked-patch antenna designs. The low profile and wide bandwidth of microstrip stacked-patch antennas makes them an attractive choice for many RF applications. It will be shown that even with moderate values of xi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> and mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> it is possible to considerably reduce the size (length, width, and thickness) of these antennas while retaining their attractive wideband characteristics. Additionally, we will explore the tradeoff between the size and gain of these antennas. Moreover, it was shown that the bandwidth of the magneto-dielectric designs exceeds that of the dielectric-only designs. For the investigation in this paper the design process was carried out via a genetic algorithm. This robust algorithm is well suited for the design of these antennas since it can readily handle numerous design parameters while optimizing the antenna for one or more design objectives. One of the key aspects of a GA is in the definition of its cost function.
Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America (2023)

Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021 among wild birds and domestic poultry across Asia, Europe, and Africa. By the end of 2021, 2.3.4.4b viruses were detected in North America, signifying further intercontinental spread. Here we show that the western movement of clade 2.3.4.4b was quickly followed by reassortment with viruses circulating in wild birds in North America, resulting in the acquisition of different combinations of ribonucleoprotein genes. These reassortant A(H5N1) viruses are genotypically and phenotypically diverse, with many causing severe disease with dramatic neurologic involvement in mammals. The proclivity of the current A(H5N1) 2.3.4.4b virus lineage to reassort and target the central nervous system warrants concerted planning to combat the spread and evolution of the virus within the continent and to mitigate the impact of a potential influenza pandemic that could originate from similar A(H5N1) reassortants.
Evaluation on the dynamic sealing capacity of underground gas storages rebuilt from gas reservoirs: A case study of Xinjiang H underground gas storage (2021)

In order to provide effective guidance for optimizing and adjusting the maximum operation pressure and dynamic monitoring well pattern of underground gas storages (hereinafter referred as gas storages) and ensure the operation safety of gas storages, this paper takes Xinjiang H gas storage whose storage capacity and peak shaving capacity are the highest in China as the research object to establish a 3D fine geological model and a 3D dynamic geomechanical model in the regional scale of H gas storage based on the alternating change characteristics of geostress field during the high-speed cyclic injection and production of gas storage, combined with the geological, seismic, logging and various laboratory core experiment results. Then, the trap dynamic sealing capacity of H gas storage under the action of alternating stress after 14 years of depletion development of its original gas reservoir and long-term high-speed injection and production after its reconstruction from the gas reservoir was evaluated comprehensively. And the following research results were obtained. First, the change of the formation pressure in H gas storage has a significant effect on the regional geostress field. Second, after the development of the original H gas reservoir, the geostress on the two sides of the fault are greatly different, but the cap rock is not deformed and failed and the reservoir controlling fault as the gas bearing boundary doesn't glide, which ensures the safety of reconstructing H gas reservoir into gas storage. Third, due to the high-speed injection and production of H gas storage, the geostress field becomes more uneven, which has a potential negative impact on the integrity of the injection and production wells of the gas storage. Fourth, during the long-term high-speed injection and production operation of H gas reservoir, the cap rock does not undergo shear and tensile failure, but the numerical simulation of geomechanics shows that the long-term high-speed injection and production of the gas storage results in the relative sliding deformation (maximum about 5 cm) on both sides of H fault in the south of the reservoir, so the sealing capacity of H fault is a weak point impacting the integrity of the gas storage. Fifth, it is recommended to deploy monitoring wells at the upper block of H fault in the south of the gas storage to strengthen the injection and production dynamic monitoring. In conclusion, this study performs a qualitative and quantitative evaluation on the trap dynamic sealing capacity of gas storages rebuilt from gas reservoirs under the action of alternating stress, and it plays an important guiding role in ensuring the long-term injection and production safety of H gas storage.
Reduced oxygen partial pressure SiGe condensation for the fabrication of compressively strained SGOI substrates (2019)

We report the use of a low oxygen partial pressure dry furnace oxidation process for the fabrication of ultra-thin compressively strained SGOI layers. The effect of a reduced oxygen partial pressure on oxidation kinetics and Ge depth profile evolution is shown. Resulting strain, SiGe surface and roughness evaluation are carried out to compare the residual strain values and the crystal defects generation to results obtained with a conventional pure oxygen process.
Mimicking the First Turn of an Alpha-Helix with an Unnatural Backbone: Conformation-Specific IR and UV Spectroscopy of Cyclically Constrained Beta/Gamma-Peptides (Dataset) (2014)

&lt;p&gt;Contained within are the text files for all experimental spectra presented in the paper as well as the Gaussian09 output files for assigned structures: Gord, JR, Walsh, PS, Fisher, BF, Gellman, SH, Zwier, TS. 2014. Mimicking the First Turn of an alpha-Helix with an Unnatural Backbone: Conformation-Specific IR and UV Spectroscopy of Cyclically Constrained beta/gamma-Peptides. Journal of Physical Chemistry B, 118(28), pp. 8246-8256.&lt;/p&gt;
Synthesis of acid-sensitive latices by ring-opening metathesis polymerization (2005)

International audience