gebhart/patrepeval huggingface dataset:
Recombinant Influenza A Viruses with Enhanced Levels of PB1 and PA Viral Protein Expression (2012)

Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruses is attenuated, and they have an enhanced shedding of noninfectious particles and are incapable of antagonizing interferon (IFN) effectively. Our findings highlight the possibility of increasing influenza virus protein expression and the need for a delicate balance between influenza viral replication, protein expression, and assembly.
Simulations of the 1993 ARSRP deep ocean seafloor scattering experiments using h a r v e s t—An adaptive wave propagation regime simulation technique (1994)

A new general hybrid technique, HARVEST (hybrid adaptive regime viscoelastic simulation technique), to solve the 2-D acoustic/viscoelastic equations for problems which encompass different wave propagation regimes, such as the relatively smooth water column and the highly heterogeneous seafloor in deep ocean seafloor scattering experiments, is presented. A Gaussian beam method is used to propagate the source field through a vertically heterogeneous water column to the scattering region near the seafloor. This extrapolated source field is inserted into a viscoelastic finite-difference method used to compute the complex acoustic/anelastic interaction of the wave field with the rough seafloor. The backscattered field is extrapolated to a receiver array distant from the scattering locale by means of the Kirchhoff integral. HARVEST is employed to simulate ocean acoustic reverberation data collected during the 1993 ARSRP (Acoustic Reverberation Special Research Program) Acoustics Cruise. HARVEST is found to successfully reproduce ocean acoustic data within the confidence limits imposed by knowledge of seafloor morphology and material properties. The nature of scattering targets is interpreted from acoustics data in terms of synthetic HARVEST simulated data. In particular, rough basement that barely protrudes the sediment cover may cause strong returns in the backscattered field.
Real-time implementation of autofocus on the TI DSC processor (2004)

This paper discusses the real-time implementation of a fast and accurate auto-focus method on the Texas Instruments DM270, a programmable processor designed specifically for digital still cameras. The DM270's programmable auto-focus hardware filter is utilized to obtain a sharpness function from a captured image. This function is then used to drive a rule-based search algorithm, which varies the focusing step size depending on the slope of the sharpness function. This leads to faster focusing speeds as compared to the standard global search algorithm. A wide variety of filters are tested by examining their performances in terms of focusing accuracy. The results show that the filters approximating the first derivative operator generate the best focusing accuracy under various focusing conditions.
Gastric Inlet Patch Containing Submucosally Infiltrating Adenocarcinoma (1997)

We describe a patient with an unusual segment of ectopic gastric mucosa in the proximal esophagus. The gastric heterotopia was circumferential and unusually long at 7 cm. It contained benign rugal-type folds, a stricture at the mid-portion of the gastric inlet patch was lined by normal antral-type gastric mucosa but harbored submucosally infiltrating adenocarcinoma. There was no evidence of Helicobacter pylori infection by biopsy or serologic screening. Malignancy, including submucosally infiltrating adenocarcinoma, should be considered in patients with strictures involving ectopic gastric mucosa in the proximal esophagus.
Dependence of the Decomposition of Trimethylaluminum on Oxygen Concentration (2010)

Trimethylaluminum (TMA) is often used as a source gas for composite semiconductor or gate insulator films containing aluminum. However, TMA readily reacts with and this reaction causes film performance to degrade. Film formation is affected by the decomposition properties of the source gas, so it is important to investigate the influence of on the decomposition behavior of TMA. The starting decomposition temperature of TMA was in an tube filled with Ar gas, and the decomposition rate increased rapidly above . However, when TMA was heated in an atmosphere containing more than , the temperature at which TMA began to decompose increased. It is assumed that this phenomenon resulted from the formation of methoxy groups through reaction between TMA and . Thus, the presence of in TMA not only caused the films to be contaminated with oxygen atoms but also altered the decomposition behavior of TMA. This means that fluctuations in the deposition rate and film performance are caused by the presence of in TMA when deposition conditions are otherwise kept constant. As a result, it is desirable that the concentration present in TMA is maintained below during deposition.
A low-loss SiN photonic integrated circuit foundry platform for waveguide-enhanced Raman spectroscopy (2021)

The development of a foundry-scale waveguide-enhanced Raman spectroscopy (WERS) platform is a vital for the widespead implementation of this analytical technique. In this work we analyze the waveguide material and fabrication processes offered by AIM Photonics with regard to their effectiveness for WERS, and other sensing techniques. Optical characterization of these materials via white light spectroscopy and fluorescence spectroscopy points to the designation of an optimal wafer composition comprising a thermal bottom oxide and an LPCVD silicon nitride waveguide. This optimal composition has no measurable fluorescence and a propagation loss of 3.2 dB/m at 1064 nm in the TM<sub>00</sub> mode. In the c/l band, the optimal wafer build has as thermal bottom oxide, a PECVD silicon nitride waveguide, and is annealed. This build has a propagation loss of 8.1 dB/m at 1550 nm in the TE<sub>00</sub> mode.
A MRI-Compatible Combined Mechanical Loading and MR Elastography Setup to Study Deformation-Induced Skeletal Muscle Damage in Rats (2017)

Deformation of skeletal muscle in the proximity of bony structures may lead to deep tissue injury category of pressure ulcers. Changes in mechanical properties have been proposed as a risk factor in the development of deep tissue injury and may be useful as a diagnostic tool for early detection. MRE allows for the estimation of mechanical properties of soft tissue through analysis of shear wave data. The shear waves originate from vibrations induced by an external actuator placed on the tissue surface. In this study a combined Magnetic Resonance (MR) compatible indentation and MR Elastography (MRE) setup is presented to study mechanical properties associated with deep tissue injury in rats. The proposed setup allows for MRE investigations combined with damage-inducing large strain indentation of the Tibialis Anterior muscle in the rat hind leg inside a small animal MR scanner. An alginate cast allowed proper fixation of the animal leg with anatomical perfect fit, provided boundary condition information for FEA and provided good susceptibility matching. MR Elastography data could be recorded for the Tibialis Anterior muscle prior to, during, and after indentation. A decaying shear wave with an average amplitude of approximately 2 μm propagated in the whole muscle. MRE elastograms representing local tissue shear storage modulus Gd showed significant increased mean values due to damage-inducing indentation (from 4.2 ± 0.1 kPa before to 5.1 ± 0.6 kPa after, p<0.05). The proposed setup enables controlled deformation under MRI-guidance, monitoring of the wound development by MRI, and quantification of tissue mechanical properties by MRE. We expect that improved knowledge of changes in soft tissue mechanical properties due to deep tissue injury, will provide new insights in the etiology of deep tissue injuries, skeletal muscle damage and other related muscle pathologies.
Glycothermal Synthesis of Scheelite-Type LiEuW2O8 Nanophosphors and Their Structural Characterization (2007)

The formation of LiEuW2O8 from a tungsten source and acetates of lithium and europium(III) by autoclave treatment in 1,4-butylene glycol, i.e., by a glycothermal reaction, was studied to explore a novel low-temperature wet chemical synthesis of scheelite-type tungstate compounds with WO4 units. When dodecatungstophosphoric acid hexahydrate (DPA) was chosen as a tungsten source, a glycothermal reaction at 300 °C produced crystalline scheelite-type LiEuW2O8 (LEW) nanophosphors in a single phase. In contrast, phase-pure crystalline LEW was not obtained using the other tungsten sources. According to the results obtained by inductively coupled plasma atomic emission spectroscopy, infrared absorption spectroscopy, and Raman spectroscopy, the DPA-derived sample contained PO4 groups, which had probably substitutionally replaced WO4. PO4 groups could play a significant role in the nucleation of scheelite-type LEW, which is composed of WO4 groups. We also discuss the nonstoichiometric structural properties of the crystalline scheelite-type LEW. LEW nanophosphors, which are an alternative for organic dyes, may be one of promising materials because of their optical function of color conversion from near UV and blue to red.
State estimation of an underwater robot using visual and inertial information (2011)

This paper presents an adaptation of a vision and inertial-based state estimation algorithm for use in an underwater robot. The proposed approach combines information from an Inertial Measurement Unit (IMU) in the form of linear accelerations and angular velocities, depth data from a pressure sensor, and feature tracking from a monocular downward facing camera to estimate the 6DOF pose of the vehicle. To validate the approach, we present extensive experimental results from field trials conducted in underwater environments with varying lighting and visibility conditions, and we demonstrate successful application of the technique underwater.
Flow-based admission control for multiple service classes in the ATM-based MPLS network (2002)

In this paper, we propose a backbone network that supports integrated as well as differentiated services (IntServ and DiffServ) through an ATM shortcut connection or label swapping of multiprotocol label switching (MPLS) using the capabilities of an underlying ATM network to realize quality of service (QoS). In the label edge router (LER), we design a DiffServ mapping algorithm and integrated packet scheduler. Also, we propose a flow-based admission control algorithm that is suitable for multiple service class environments. This algorithm can achieve the two objects of reliable delay bounded QoS provisioning and high resource utilization using flow-based traffic classification.
Mechanical amplifier squeezes Brownian motion (1991)

Experiments as diverse as atomic force microscopy and gravitational wave detectors rely on extremely sensitive sensors of mechanical force. A force sensor typically consists of a test mass, on which the force acts, and a transducer, which converts the motion of the test mass to an electrical signal. Often the electronic noise of the transducer is the limiting factor in the sensitivity of a force sensor.
Gamma δ TCR+ hybridomas derived from mice preimmunized via the portal vein adoptively transfer increased skin allograft survival in vivo (1996)

C57BL/6 mice receiving pretransplant immunization with C3H.SW spleen cells via the portal vein, but not the vena cava, show Ag-specific delayed rejection of allogeneic C3H.SW skin grafts. This delayed rejection is not seen if preimmunization is performed in gamma delta TCR knockout (C57BL/6-Tcrdtm1Mom) mice. gamma delta TCR+ and alpha beta TCR+ hybridoma cells were prepared from Peyer's patch cells harvested from C57BL/6 mice 4 days following portal venous immunization with 100 x 10(6) irradiated C3H.SW spleen cells and skin grafting with C3H.SW tail skin. After recloning, these hybridoma cells were tested for cytokine production in vitro following restimulation with irradiated C3H.SW spleen cells and for their ability to delay rejection of C3H.SW skin grafts after adoptive transfer to C57BL/6 mice. Delayed graft rejection was a function of cells that showed preferential production of IL-10, not IFN-gamma, in vitro, independent of the source (vena cava or portal vein immunized mice) or the TCR phenotype of the hybridoma. Simultaneous infusion of anti-IL-10 mAb abolished this graft prolongation effect of transferred gamma delta TCR+ hybridomas. Hybridoma cells producing IL-10 on restimulation could polarize cytokine production from freshly stimulated mesenteric lymph node away from production of IL-2 and IFN-gamma, and toward IL-4, IL-10, and TGF-beta production. This immunoregulation by hybridoma cells in vivo and in vitro was observed even for third party Ag-stimulated mice/cells as long as the hybridoma cells themselves received stimulation with their specific Ag.
External PD resistance of thermoplastic and XLPE containing voltage stabilizers (1998)

Films based on a wide range of thermoplastic and XLPE (crosslinked polyethylene) including compounds containing aromatic voltage stabilizers (fluoranthene, naphthalene, pyrene, vinylnaphthalene and anthracene) were exposed to external PD (partial discharge) in dry air at 298 K. Very low molar mass PE, M/sub w/=13600 g/mol, exhibited a very low resistance towards PD. It is believed that the low concentration of interlamellar tie chains and the pronounced mechanical brittleness caused early void formation induced by the mechanical action of the plasma. PE with a higher molar mass showed a PD life that was essentially independent of molar mass, degree of crosslinking, crystallinity and crystal thickness. The added voltage stabilizers had no effect on the PD lifetime.
High-Temperature Operation of 50 A (1600 A/cm<sup>2</sup>), 600 V 4H-SiC Vertical-Channel JFETs for High-Power Applications (2008)

In this work we have demonstrated the high-temperature operations of 600 V/50 A 4HSiC vertical-channel junction field-effect transistors (VJFETs) with an active area of 3 mm2. Specific-on resistance (RONSP) in the linear region of a single die is less than 2.6 mW.cm2 while the drain-source current is over 50 A under a gate bias (VGS) of 3 V. A reverse blocking gain of 54 is obtained at gate bias ranging from -13 V to -23 V and drain-source leakage current (IRDS) of 200 μA. To demonstrate the use of SiC VJFETs for high-power applications, eight 3 mm2 SiC VJFETs are bonded in a high current 600-V module. RONSP in the linear region of these eight-paralleled SiC VJFETs is 2.8 mW.cm2 at room temperature and increased to 5.35 mW.cm2 at an ambient temperature of 175 °C in air, corresponding to a shift of 0.61%/°C from room temperature to 175 °C. Meanwhile, the forward current is over 360 A at room temperature and reduces to 188 A at 175 °C at drain-source bias (VDS) of 5.25 V and VGS of 3 V.
Use of Supramolecular Assemblies as Lithographic Resists (2017)

A new resist material for electron beam lithography has been created that is based on a supramolecular assembly. Initial studies revealed that with this supramolecular approach, high-resolution structures can be written that show unprecedented selectivity when exposed to etching conditions involving plasmas.
Seroepidemiology of Hepatitis C Among Drug Users at a Detoxification Center in Southeast China (2020)

Background: Hepatitis C virus (HCV) infection is prevalent worldwide, especially among drug users. The epidemiology of HCV is rarely reported among drug users in developing countries, including China. Objectives: We aimed to describe the seroepidemiology of HCV infection in drug users at a Detoxification Center in Southeast China. Methods: With approval from the Shantou Center for Disease Control, the archived data of drug users (n = 5,228) at the largest monitored-detoxification center in Shantou during 2011 - 2017 were analyzed for demographics, risk behaviors, and HCV serology. Results: Among HCV-tested drug users, 36.9% (1930/5228) were people who inject drugs (PWID). The mean annual HCV seroprevalence rate over the seven-year study period was 36.3% for all drug users, including 67.3% and 16.6% for PWID and non-PWID, respectively, with the highest prevalence (78.1%) in 2017 and the lowest prevalence (58.6%) in 2015 for PWID. Independent risk factors of HCV infection identified by multiple logistic regression analysis were engaging in unprotected sex (OR = 1.553, 95% CI = 1.078 - 2.236), injecting drugs (10.28, 8.98 - 11.763), and sharing needles/syringes (2.24, 1.129 - 4.445) for all drug users and sharing needles/syringes (2.062, 1.438 - 2.957) for PWID. Conclusions: This study reports the seroepidemiology of drug users in the monitored Detoxification Center in Southeast China. A relatively high HCV positivity rate, especially among PWID, their high-risk behaviors and low education, and lack of institutional interventions of HCV monitoring and transmission call for government-sponsored educational programs to raise drug usersâ awareness of the risk of HCV infection and other co-infections and monitoring of the infectious status and treatment of HCV-infected drug users.
Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus (2022)

Natural products provide an important source of pharmaceuticals and chemical tools. Traditionally, assessment of unexplored microbial phyla has led to new natural products. However, with every new microbe, the number of orphan biosynthetic gene clusters (BGC) grows. As such, the more difficult proposition is finding new molecules from well-studied strains. Herein, we targeted Streptomyces rimosus, the widely-used oxytetracycline producer, for the discovery of new natural products. Using MALDI-MS-guided high-throughput elicitor screening (HiTES), we mapped the global secondary metabolome of S. rimosus and structurally characterized products of three cryptic BGCs, including momomycin, an unusual cyclic peptide natural product with backbone modifications and several non-canonical amino acids. We elucidated important aspects of its biosynthesis and evaluated its bioactivity. Our studies showcase HiTES as an effective approach for unearthing new chemical matter from "drained" strains.
Extreme Tuning of Microphotonic Structures Using Optical Forces (2010)

We show evidence of extreme tuning of micro-photonic resonances (31.4 nm) using optical gradient forces. We estimate the static mechanical displacements to be as large as 60 nm using mW level optical powers.
Quasi-adiabatic Continuation for Disordered Systems: Applications to Correlations, Lieb-Schultz-Mattis, and Hall Conductance (2010)

We present a possible definition of a mobility gap for a many-body quantum system, in analogy to definitions of dynamical localization for single particle systems. Using this definition, we construct "corrected" quasi-adiabatic continuation operators. Under an appropriate definition of a unique ground state, we show how to introduce virtual fluxes. Armed with these results, we can directly carry over previous results in the case of a spectral gap. We present a proof of decay of correlation functions and we present a proof of Hall conductance quantization under very mild density-of-states assumptions defined later. We also generalize these definitions to the case of a "bulk mobility gap", in the case of a system with boundaries, and present a proof of Hall conductance quantization on an annulus under appropriate assumptions. Further, we present a new "optimized" quasi-adiabatic continuation operator which simplifies previous estimates and tightens bounds in certain cases. This is presented in an appendix which can be read independently of the rest of the paper as it also improves estimates in the case of systems with a spectral gap. This filter function used decays in time at least as fast as ${\cal O}(\exp(-t^α))$ for all $α&lt;1$, a class of decay called subexponential (a tighter description of what is possible is below). Using this function it is possible to tighten recent estimates of the Hall conductance quantization for gapped systems\cite{hall} to a decay which is subexponential in system size.
Using the Traction Drive as the Sensor to Evaluate and Track Deterioration in Electrified Vehicle Gearboxes (2013)

With the increase in electrified traction applications, high-performance electric motor drives are now frequently coupled to gear transmissions in vehicles. It is appropriate to note that these drives have the capability to be used as a built-in sensor to estimate important characteristics of the mechanical system. The techniques to do this proposed in this paper do not require any change in the motor drive sensors and can be performed in real time during continuously changing conditions. By estimating the states of each element as a function of its position, spatial synchronous averaging can be used on each element to identify its unique characteristics, including deterioration. This paper presents the development and evaluation of these technologies and an exploration of the limitations of the proposed technologies.
PDZK1 Is Required for Maintaining Hepatic Scavenger Receptor, Class B, Type I (SR-BI) Steady State Levels but Not Its Surface Localization or Function (2006)

PDZK1 is a multi-PDZ domain-containing adaptor protein that binds to the C terminus of the high density lipoprotein receptor, scavenger receptor, class B, type I (SR-BI), and controls the posttranscriptional, tissue-specific expression of this lipoprotein receptor. In the absence of PDZK1 (PDZK1(-/-) mice), murine hepatic SR-BI protein levels are very low (<5% of control). As a consequence, abnormal plasma lipoprotein metabolism ( approximately 1.5-1.7-fold increased total plasma cholesterol carried in both normal size and abnormally large high density lipoprotein particles) resembles, but is not as severely defective as, that in SR-BI(-/-) mice. Here we show that the total plasma cholesterol levels and size distribution of lipoproteins are virtually identical in SR-BI(-/-) and SR-BI(-/-)/PDZK1(-/-) mice, indicating that most, if not all of the effects of PDZK1 on lipoprotein metabolism are likely because of the effects of PDZK1 on SR-BI. Hepatic overexpression of wild-type SR-BI in PDZK1(-/-) mice restored near or greater than normal levels of cell surface-expressed, functional SR-BI protein levels in the livers of SR-BI(-/-)/PDZK1(-/-) mice and consequently restored apparently normal lipoprotein metabolism in the absence of PDZK1. Thus, PDZK1 is important for maintaining adequate steady state levels of SR-BI in the liver but is not essential for cell surface expression or function of hepatic SR-BI.
Extrusion (2017)

No AccessUnderstanding Polymer ProcessingOct 2017ExtrusionTim A. OsswaldTim A. Osswaldhttps://doi.org/10.3139/9781569906484.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2017Pages: 77-95Print ISBN: 978-1-56990-647-7eISBN: 978-1-56990-648-4 Copyright & Permissions© 2017 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...