gebhart/patrepeval huggingface dataset:
Non-Linear Viscoelastic Mechanics of Native and Engineered Ligaments and Tendons (2011)

Patellar tendon (PT) autografts and allografts are the most common methods currently used to replace a torn anterior cruciate ligament (ACL). The PT is not only much stiffer than the ACL it replaces it also exhibits qualitatively and quantitatively different non-linear viscoelastic behavior from those of the ACL. These mis-matched biomechanics may be contributing to the high incidence of early onset osteoarthritis suffered by patients who have had ACL surgeries. Thus there is a need for an ACL graft that can reproduce normal ligament biomechanics and knee function. This talk examines the inhomogeneous, non-linear viscoelastic response of native ACL and of a tissue engineered ACL graft designed to rapidly grow and remodel in vivo to restore the proper biomechanical properties of native ligament. The results using this graft as an ACL replacement are compared against those using a PT autograft for the ACL replacement. Uniaxial loading reveals that after nine months as an ACL replacement, the tissue-engineered graft develops a strain contour pattern closely resembling that of native ACL whereas the PT graft fails to similarly remodel in vivo.
Quality-Cost Scalable Chip Level Equalization in HSDPA Receiver (2006)

info:eu-repo/semantics/published
CEST MRI reveals a correlation between visceral fat mass and reduced myocardial creatine in obese individuals despite preserved ventricular structure and function (2019)

Systolic cardiac function is typically preserved in obese adults, potentially masking underlying declines in cardiomyocyte metabolism that may contribute to heart failure. We used chemical exchange saturation transfer (CEST) MRI, a sensitive method for measurement of myocardial creatine, to examine whether myocardial creatine levels correlate with cardiac structure, contractile function, or visceral fat mass in obese adults. In this study, obese (body mass index, BMI > 30, n = 20) and healthy (BMI < 25, n = 11) adults were examined with dual-energy x-ray absorptiometry to quantify fat masses. Cine MRI and myocardial tagging were performed at 1.5 T to measure ventricular structure and global function. CEST imaging with offsets in the range of ±10 parts per million (ppm) were performed in one mid-ventricular slice, where creatine CEST contrast was calculated at 1.8 ppm following field homogeneity correction. Ventricular structure, global function (ejection fraction 69.4 ± 4.3% healthy versus 69.6 ± 9.3% obese, NS), and circumferential strain (-17.0 ± 2.3% healthy versus -16.5 ± 1.5% obese, NS) and strain rate were preserved in obese adults. However, creatine CEST contrast was significantly reduced in obese adults (6.8 ± 1.3% healthy versus 4.1 ± 2.7% obese, p = 0.001). Creatine CEST contrast was inversely correlated with total body fat% (ρ = -0.45, p = 0.011), visceral fat mass (ρ = -0.58, p = 0.001), and septal wall thickness (ρ = -0.44, p = 0.013), but uncorrelated to ventricular function or contractile function. In conclusion, creatine CEST-MRI reveals a strong correlation between heightened body and visceral fat masses and reduced myocardial metabolic function that is independent of ventricular structure and global function in obese adults.
Evaluation of the Use of Performance Reference Compounds in an Oasis-HLB Adsorbent Based Passive Sampler for Improving Water Concentration Estimates of Polar Herbicides in Freshwater (2010)

Passive samplers such as the Polar Organic Chemical Integrative Sampler (POCIS) are useful tools for monitoring trace levels of polar organic chemicals in aquatic environments. The use of performance reference compounds (PRC) spiked into the POCIS adsorbent for in situ calibration may improve the semiquantitative nature of water concentration estimates based on this type of sampler. In this work, deuterium labeled atrazine-desisopropyl (DIA-d5) was chosen as PRC because of its relatively high fugacity from Oasis HLB (the POCIS adsorbent used) and our earlier evidence of its isotropic exchange. In situ calibration of POCIS spiked with DIA-d5 was performed, and the resulting time-weighted average concentration estimates were compared with similar values from an automatic sampler equipped with Oasis HLB cartridges. Before PRC correction, water concentration estimates based on POCIS data sampling rates from a laboratory calibration exposure were systematically lower than the reference concentrations obtained with the automatic sampler. Use of the DIA-d5 PRC data to correct POCIS sampling rates narrowed differences between corresponding values derived from the two methods. Application of PRCs for in situ calibration seems promising for improving POCIS-derived concentration estimates of polar pesticides. However, careful attention must be paid to the minimization of matrix effects when the quantification is performed by HPLC-ESI-MS/MS.
Fixed and Mobile Convergence: Needs and Solutions (2014)

The drivers of Fixed and Mobile Convergence (FMC) are discussed. A reference framework for FMC proposed by European project COMBO is then presented. Some use cases of FMC are described, showing the needs for mutualization and convergence of fixed and mobile broadband networks. Five network scenarios providing technical solutions to FMC use cases are proposed. They target an optimal and seamless quality of experience for the end user together with an optimized network infrastructure ensuring increased performance, flexibility, reduced cost and reduced energy consumption.
The Effect of Early Range of Motion on Quality of Life, Clinical Outcome, and Repair Integrity After Arthroscopic Rotator Cuff Repair (2017)

Level II, lesser-quality randomized controlled trial.
PREDICTING HUMAN MOVEMENT TYPE BASED ON MULTIPLE ACCELEROMETERS USING MOVELETS (2013)

We introduce statistical methods for prediction of types of human movement based on three tri-axial accelerometers worn simultaneously at the hip, left, and right wrist. We compare the individual performance of the three accelerometers using movelets and propose a new prediction algorithm that integrates the information from all three accelerometers. The development is motivated by a study of 20 older subjects who were instructed to perform 15 different types of activities during in-laboratory sessions. The differences in the prediction performance for different activity types among the three accelerometers reveal subtle yet important insights into how the intrinsic physical features of human movements could be effectively utilized in prediction. The proposed integrative movelet method takes into account those findings to augment the prediction accuracy and improve our understanding of human movement measurements.
Synthesis of interface controllers from timing diagram specifications (2002)

We present a method for verifying the realizability of a timing diagram, ensuring the synthesis of the underlying interface is possible. If necessary, a heuristic is introduced to render explicit hidden timing constraints implied by the specification. A relative schedule of output events is computed, accepting input events from the complete timing space defined by the assumed constraints on the environment.
Self-wavelength-initialization method using a dedicated light path of WDM-PON (2012)

We propose wavelength initialization technique which is automatically performed using WDM-PON light path. Compare with other techniques, the least space and the lowest cost are consumed for realizing. The initialization time of the worst case, for 32th channel, is below 1 second.
Liver-kidney microfluidic bioreactor for cell co-culture in drug studies (2010)

International audience
Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors (2020)

Here, we demonstrated that CPC634 enhanced the intratumoral total docetaxel exposure compared with conventional docetaxel. The lower incidence of neutropenia during CPC634 treatment is presumably related to lower plasma <i>C</i> <sub>max</sub> of released docetaxel. The unique pharmacokinetic profile of CPC634 nanoparticles has the potential to improve docetaxel treatment. A phase II efficacy trial of CPC634 is currently ongoing.
Quick Verification of RSA Signatures (2011)

Speeding up RSA signature authentication is important in various scenarios. We propose here a scheme for quick verification of RSA signatures, that is mostly appropriate when the public exponent is small. This scheme pre-computes the quotients required to perform modular reduction during verification, and includes them as part of the certificate that is being authenticated. This allows for replacing expensive modular reduction steps by less costly integer multiplications and subtractions. As a result, the scheme achieves significant speedup as well as reduction in the code size and complexity. The quotients are computed using only the public key and the signature, and do not need to involve the signing procedure, nor require any changes in it. The verification scheme that uses these quotients as part of a quick verification flow is no weaker than the cryptographic primitive on which the signature scheme is based. The performance results that are reported in the paper demonstrate the advantage of the proposed scheme.
Bilayer Electrolytes for Low Temperature and Intermediate Temperature Solid Oxide Fuel Cells – A Review (2019)

The commercialisation of solid oxide fuel cell (SOFC) technology would benefit dramatically by a reduction of the operating temperature to a lower range (500–650 °C). Unfortunately, the ionic conductivity of YSZ and electrode performance decrease significantly at low temperatures resulting in low power density SOFCs. Doped ceria materials have ionic conductivity orders of magnitude higher than YSZ and have been extensively explored as an alternative electrolyte material. However, doped ceria reduces under fuel conditions at the anode side resulting in internal leakage current. This work is primarily focused on reviewing the recent developments of the concept of a bilayer electrolyte SOFC where ceria is the main electrolyte and the second electrolyte serves to block the leakage current. A thorough survey of works in the literature reveals that bismuth oxide/ceria bilayer electrolyte SOFCs yield higher power density compared to zirconia/ceria bilayer electrolyte SOFCS mainly due to the much higher ionic conductivity of stabilised bismuth oxide compositions compared to YSZ. A proper ceria/bismuth oxide thickness ratio is of great importance and hence needs to be tuned carefully. In addition, bilayer electrolytes can serve other functions in SOFC structures such as a diffusion barrier layer between the electrolyte and adjacent electrodes or a fast oxide ion conductor to promote catalytic activity toward oxygen reduction.
Allosteric Modulation of Native Cochlear P2X Receptors: Insights from Comparison with Recombinant P2X<sub>2</sub> Receptors (2003)

Extracellular adenosine 5'-triphosphate (ATP)-gated ion channels assembled from P2X receptor subunits exhibit subunit-selective allosteric modulation by protons and divalent cations. In voltage-clamped guinea-pig cochlear outer hair cells (OHC) and Deiters' cells (DC), H(+) and Cu(2+), but not Zn(2+), enhanced the P2X receptor-mediated inward currents. Acid pH (6.5) potentiated OHC ATP-gated currents by 45%. Co-application of Cu(2+) (1-40 microM) with ATP increased the response by 20%. In DCs, ATP-gated currents were potentiated 85% by acid pH, and 70% by Cu(2+). Alkaline pH inhibited ATP-gated inward currents by 73% in OHCs and 85% in DCs. Zn(2+) was either ineffective (1-10 microM) or inhibitory (40-400 microM). Recombinant rat P2X(2) receptor-mediated inward currents in XENOPUS oocytes displayed allosteric modulation that was different from the native guinea-pig cochlear P2X receptors. The oocyte ATP-gated inward current was potentiated 450% by shifting from pH 7.5 to pH 6.5, and 130% with 40 microM Cu(2+). The enhanced response to ATP with acid pH and Cu(2+) is a signature of the P2X(2) subunit. In contrast to native guinea-pig cochlear cells, extracellular Zn(2+) (40 microM) increased the recombinant ATP-gated inward current by 200% in oocytes. These results suggest that the positive allosteric modulation of cochlear OHC and DC ATP-gated ion channels by protons and Cu(2+) arises in part from the P2X(2) receptor subunit, with additional regulatory elements.
Interferon induction by avian infectious bronchitis virus in chickens. (1982)

[in Japanese]
The message-driven processor: a multicomputer processing node with efficient mechanisms (1992)

The message-driven processor (MDP), a 36-b, 1.1-million transistor, VLSI microcomputer, specialized to operate efficiently in a multicomputer, is described. The MDP chip includes a processor, a 4096-word by 36-b memory, and a network port. An on-chip memory controller with error checking and correction (ECC) permits local memory to be expanded to one million words by adding external DRAM chips. The MDP incorporates primitive mechanisms for communication, synchronization, and naming which support most proposed parallel programming models. The MDP system architecture, instruction set architecture, network architecture, implementation, and software are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ITR/SY: a distributed programming infrastructure for integrating smart sensors (2009)

As we observed at the time of filing the annual report in August 2008, that that was really a final report on the project. The only unexpended funds at that time was the remaining in the category of REU for which NSF had given a one-year extension. Therefore, we present the work done with the undergraduates in the following section and then reproduce the contents of the annual report from August 2008 for the sake of completeness of this final report.
Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury (2010)

Acute kidney injury induces the loss of renal microvessels, but the fate of endothelial cells and the mechanism of potential vascular endothelial growth factor (VEGF)-mediated protection is unknown. Cumulative cell proliferation was analyzed in the kidney of Sprague-Dawley rats following ischemia-reperfusion (I/R) injury by repetitive administration of BrdU (twice daily) and colocalization in endothelial cells with CD31 or cablin. Proliferating endothelial cells were undetectable for up to 2 days following I/R and accounted for only ∼1% of BrdU-positive cells after 7 days. VEGF-121 preserved vascular loss following I/R but did not affect proliferation of endothelial, perivascular cells or tubular cells. Endothelial mesenchymal transition states were identified by localizing endothelial markers (CD31, cablin, or infused tomato lectin) with the fibroblast marker S100A4. Such structures were prominent within 6 h and sustained for at least 7 days following I/R. A Tie-2-cre transgenic crossed with a yellow fluorescent protein (YFP) reporter mouse was used to trace the fate of endothelial cells and demonstrated interstititial expansion of YFP-positive cells colocalizing with S100A4 and smooth muscle actin following I/R. The interstitial expansion of YFP cells was attenuated by VEGF-121. Multiphoton imaging of transgenic mice revealed the alteration of YFP-positive vascular cells associated with blood vessels characterized by limited perfusion in vivo. Taken together, these data indicate that vascular dropout post-AKI results from endothelial phenotypic transition combined with an impaired regenerative capacity, which may contribute to progressive chronic kidney disease.
Low [Mg2+]oinduces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases (2000)

The present study was designed to investigate the mechanism of action of low extracellular magnesium ion concentration ([Mg(2+)](o)) on isolated canine basilar arteries and single cerebral vascular smooth muscle cells from these arteries. Low-[Mg(2+)](o) medium (0-0.6 mM) produces endothelium-independent contractions in isolated canine basilar arteries in a concentration-dependent manner; the lower the concentration of [Mg(2+)](o), the stronger the contractions. The low-[Mg(2+)](o) medium-induced contractions are significantly attenuated by pretreatment of the arteries with low concentrations of either SB-203580, U-0126, PD-98059, genistein, or an Src homology 2 (SH2) domain inhibitor peptide. IC(50) levels obtained for these five antagonists are consistent with reported inhibitor constant (K(i)) values for these tyrosine kinase and mitogen-activated protein kinase (MAPK) antagonists. Low-[Mg(2+)](o) medium (0-0.6 mM) produces transient intracellular calcium ion concentration ([Ca(2+)](i)) peaks followed by a slow, sustained, and elevated plateau of [Ca(2+)](i) in primary single smooth muscle cells from canine basilar arteries. Low-[Mg(2+)](o) medium induces rapid and stable increases in [Ca(2+)](i); these increases are inhibited markedly in the presence of either SB-203580, U-0126, PD-98059, genistein or a SH2 domain inhibitor peptide. Several specific antagonists of known endogenously formed vasoconstrictors do not inhibit or attenuate either the low-[Mg(2+)](o)-induced contractions or the elevation of [Ca(2+)](i). The present study suggests that activation of several cellular signaling pathways, such as protein tyrosine kinases (including the Src family) and MAPK, appears to play important roles in low-[Mg(2+)](o)-induced contractions and the elevation of [Ca(2+)](i) in smooth muscle cells from canine basilar arteries.
Using of Behavioral level AMS & RF Simulation for Validation Test Set Optimization (2007)

International audience
Primary and Secondary Aminophosphines as Novel P‐Stereogenic Building Blocks for Ligand Synthesis (2010)

Die Reaktivität der Aminogruppe P-stereogener Aminophosphane ermöglicht Folgereaktionen mit der Aminophosphaneinheit, bei denen die Chiralität am Phosphoratom erhalten bleibt (siehe Bild; Rh grün). P-stereogene Aminodiphosphanliganden sind einfach in optisch reiner Form zugänglich, weisen charakteristische elektronische und Strukturmerkmale auf und können in asymmetrischen Hydrierungen eingesetzt werden. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Portable Well Point Sampler for Plume Tracking (1984)

Abstract For regions of shallow ground water, a shallow well point sampler can provide cost‐effective sampling of contaminant plumes. A miniature well point sampler allows rapid sampling of ground water down to a maximum depth of 12 feet below grade. A high ratio of striking force to cross‐sectional area of the shaft enables the well point to penetrate soils grading from silt through sand to fine gravel. Three slot sizes have proved satisfactory for the slotted well point. For fine gravel through silty sand, a receiver flask serving as a silt trap with a hand pump can withdraw water samples. For silt or clay, a special shielded point is used to expose a porous screen upon withdrawal of the shaft. The points can be left imbedded in the strata and a vacuum drawn to recover a sample under saturated or unsaturated conditions. Such a sampler has been shown to be effective in tracing plumes from individual on‐site septic systems and hazardous waste sites. The text describes a simple procedure for plume analysis and description of the extent of dewatered strata near the point based upon different sample volumes. The probe has been used with conductivity meters and fluorometers for profiling subsurface plumes. A cost comparison is shown between monitoring well installation and the portable well point for varying sample frequency and depth.
Assessment of the Distributed Generation Market Potential for Solid Oxide Fuel Cells (2013)

NETL analyzed the strengths of the solid oxide fuel cell (SOFC) system in conjunction with distributed generation (DG) market segments in the U.S. and determined that natural gas compressor stations, grid strengthening, and data centers were potential early market-entry opportunities. These three DG market segments are projected to demand two gigawatts of additional power between now and 2018 and 25 GWs through 2040. This analysis shows that the DG SOFC system becomes cost competitive with other fossil-fuel based DG technologies after 25 MWe of installed capacity, around 2025. The SOFC DG application validates and enables utility scale fuel cell systems with carbon capture, and forms an essential first phase of the NETL technology development roadmap.
Exploring SOI device structures and interconnect architectures for low-power high-performance circuits (2002)

Vertical integration technology offers numerous advantages over conventional structures. Double-gate transistors can be easily fabricated for better device characteristics, and multiple device layers can be vertically stacked for better interconnect performance. In the paper, the authors explore the suitable device structures and interconnect architectures for multi-device-layer three-dimensional (3D) integrated circuits and study how 3D silicon-on-insulator (SOI) circuits can better meet the performance and power dissipation requirements projected by International Technology Roadmap for Semiconductors (ITRS) for future technology generations. Results demonstrate that double-gate SOI circuits can achieve as much as 20% performance gain and 30% power delay product reduction over single-gate SOI. More important, for interconnect-dominated circuits, 3D integration offers significant performance improvement. Compared to 2D integration, most 3D circuits can be clocked at much higher frequencies (double or even triple). 3D circuits, with suitable SOI device structures, can be a viable solution for future low-power high-performance applications.
Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees (2007)

Orthologs are genes in different species that evolved from a common ancestral gene by speciation. Currently, with the rapid growth of transcriptome data of various species, more reliable orthology information is prerequisite for further studies. However, detection of orthologs could be erroneous if pairwise distance-based methods, such as reciprocal BLAST searches, are utilized. Thus, as a sub-database of H-InvDB, an integrated database of annotated human genes (http://h-invitational.jp/), we constructed a fully curated database of evolutionary features of human genes, called 'Evola'. In the process of the ortholog detection, computational analysis based on conserved genome synteny and transcript sequence similarity was followed by manual curation by researchers examining phylogenetic trees. In total, 18 968 human genes have orthologs among 11 vertebrates (chimpanzee, mouse, cow, chicken, zebrafish, etc.), either computationally detected or manually curated orthologs. Evola provides amino acid sequence alignments and phylogenetic trees of orthologs and homologs. In 'd(N)/d(S) view', natural selection on genes can be analyzed between human and other species. In 'Locus maps', all transcript variants and their exon/intron structures can be compared among orthologous gene loci. We expect the Evola to serve as a comprehensive and reliable database to be utilized in comparative analyses for obtaining new knowledge about human genes. Evola is available at http://www.h-invitational.jp/evola/.
Antitubercular Agents. Part 2. New Thiolactomycin Analogues Active Against Mycobacterium tuberculosis. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.