gebhart/patrepeval huggingface dataset:
RAFDA: Middleware Supporting the Separation of Application Logic from Distribution Policy (2010)

Middleware technologies often limit the way in which object classes may be used in distributed applications due to the fixed distribution policies imposed by the Middleware system. These policies permeate the applications developed using them and force an unnatural encoding of application level semantics. For example, the application programmer has no direct control over inter-address-space parameter passing semantics since it is fixed by the application's distribution topology which is dictated early in the design cycle by the Middleware. This creates applications that are brittle with respect to changes in the way in which the applications are distributed. This paper explores technology permitting arbitrary objects in an application to be dynamically exposed for remote access. Using this, the application can be written without concern for its distribution with object placement and distribution boundaries decided late in the design cycle and even dynamically. Inter-address-space parameter passing semantics may also be decided independently of object implementation and at varying times in the design cycle, again, possibly as late as run-time. Furthermore, transmission policy may be defined on a per-class, per-method or per-parameter basis maximizing plasticity. This flexibility is of utility in the development of new distributed applications and the creation of management and monitoring infrastructures for existing applications.
Whatʼs New in Pediatric Orthopaedics (2005)

The Journal of Bone & Joint Surgery: May 2005 - Volume 87 - Issue 5 - p 1167 doi: 10.2106/JBJS.8705.ebo3
Spatiotemporally Correlated Deterministic Rayleigh Fading Model for Smart Antenna Systems (2000)

This paper evaluates the performance of the switching arbiter based on priority polling concept, which is the core part of the internal high-speed switching fabric of open-architecture AICPS(Advanced Information Communication Processing System). The priority polling scheme enables versatile switching capabilities for the multimedia applications and flexibility for the characteristics of the network interface. In evaluating the performance, we used the method of analysis and simulation. We assumed the input traffic as either Poisson or MMPP, and the service discipline as polling frequency in accordance with each node's traffic load condition. When the 50:50 total traffic load ratio of the high-load ATM interface nodes to the relatively low-load line-interface ones is assumed, three times high ATM interface node polling frequency produces the optimal overall system performance while reducing the needed buffer size to 50% of the other general circular polling systems.
Multifunctional Biodegradable Vascular PLLA Scaffold with Improved X-ray Opacity, Anti-Inflammation, and Re-Endothelization (2021)

Poly(L-lactic acid) (PLLA) has been used as a biodegradable vascular scaffold (BVS) material due to high mechanical property, biodegradability, and biocompatibility. However, acidic byproducts from hydrolysis of PLLA reduce the pH after the surrounding implanted area and cause inflammatory responses. As a result, severe inflammation, thrombosis, and in-stent restenosis can occur after implantation by using BVS. Additionally, polymers such as PLLA could not find on X-ray computed tomography (CT) because of low radiopacity. To this end, here, we fabricated PLLA films as the surface of BVS and divided PLLA films into two coating layers. At the first layer, PLLA film was coated by 2,3,5-triiodobenzoic acid (TIBA) and magnesium hydroxide (MH) with poly(D,L-lactic acid) (PDLLA) for radiopaque and neutralization of acidic environment, respectively. The second layer of coated PLLA films is composed of polydopamine (PDA) and then cystamine (Cys) for the generation of nitric oxide (NO) release, which is needed for suppression of smooth muscle cells (SMCs) and proliferation of endothelial cells (ECs). The characterization of the film surface was conducted via various analyses. Through the surface modification of PLLA films, they have multifunctional abilities to overcome problems of BVS effectively such as X-ray penetrability, inflammation, thrombosis, and neointimal hyperplasia. These results suggest that the modification of biodegradable PLLA using TIBA, MH, PDA, and Cys will have important potential in implant applications.
TeamSearch: comparing techniques for co-present collaborative search of digital media (2006)

Interactive tables can enhance small group colocated collaborative work in many domains. One application enabled by this new technology is copresent, collaborative search for digital content. For example, a group of students could sit around an interactive table and search for digital images to use in a report. We have developed TeamSearch, an application that enables this type of activity by supporting group specification of Boolean style queries. We explore whether TeamSearch should consider all group members' activities as contributing to a single query or should interpret them as separate, parallel search requests. The results reveal that both strategies are similarly efficient, but that collective query formation has advantages in terms of enhancing group collaboration and awareness, allowing users to bootstrap query specification skills, and personal preference. This suggests that team centric ills may offer benefits beyond the "staples" of efficiency and result quality that are usually considered when designing search interfaces.
Polyurethane morphologies and their response to strain studied by SAXS (2015)

Oral presentation given at the 6th International Conference on Synchrotron Radiation in Polymer Science, held in Madrid (Spain) on September 7-10th, 2015.
Shape change of cured 2D and 3D nanostructures from imprint lithography (2015)

Nanosculpting, the fabrication of two- and three-dimensional shapes at the nanoscale, enables applications in photonics, metamaterials, multi-bit magnetic memory, and bio-nanoparticles. A promising high resolution and high throughput method for nanosculpting is nanoimprint lithography (NIL). A key requirement to achieving manufacturing viability of nanosculptures in NIL is maintaining image fidelity through each step of the imprinting process. In particular, polymer densification during UV curing can distort the imprinted image. Here we study the shape changes introduced by polymer densification and develop a forward method for predicting changes in nanoscale geometries from UV curing. We show that shape changes by polymer densification are governed by the Poisson’s ratio, the shrinkage coefficient of the polymer resist, and the geometric aspect ratios of the nanosculpted shape. We also show that the size of the residual layer does not impact the final profile of the imprinted shape.
The Selective Removal of Pachytene Spermatocytes Using Methoxy Acetic Acid as an Approach to the Study In Vivo of Paracrine Interactions in the Testis (1988)

Testicular weight and morphology, serum gonadotropins, intratesticular levels of testosterone and ABP levels in testicular interstitial fluid were studied in adult rats at intervals of 1 to 70 days after a single oral dose of 650 mg/kg methoxy acetic acid. At 3 days, this treatment resulted in the selective loss or depletion of pachytene and later spermatocytes from seminiferous tubules at all stages other than VIII to XI of the spermatogenic cycle. At later times this lesion was expressed as an absence mainly of round (14 days) or elongated (21 days) spermatids from the majority of seminiferous tubules. Other than these changes, spermatogenesis did not appear to be affected by treatment and was qualitatively normal in all tubules at 70 days after treatment. As deduced from cell counts at 3 days posttreatment, the initial action of methoxy acetic acid was restricted to late zygotene spermatocytes (stage XII) and pachytene spermatocytes at all stages other than early- to mid-stage VII. Levels of FSH in serum and those of ABP in testicular interstitial fluid indicated that Sertoli cell function was altered in rats treated with methoxy acetic acid. Both were increased at 1 to 3 days posttreatment, returned to normal at 7 to 14 days but were increased again at 21 days before finally returning to control levels at 28 days. In contrast, the levels of testosterone in serum, isolated seminiferous tubules and testicular interstitial fluid were unaffected by treatment, as also were the serum levels of LH. The two periods of increase in FSH and ABP levels coincided with the times of greatest decrease (approximately 20%) in testicular weight, and may be related either to the type of germ cell missing from the affected tubules and/or to the stage of the cycle of the affected (or unaffected) tubules. These data suggest that chemicals such as methoxy acetic acid may prove useful in the study of paracrine interactions in vivo.
Generation of flow cytometry data files with a potentially infinite number of dimensions (2008)

Abstract Immunophenotypic characterization of B‐cell chronic lymphoproliferative disorders (B‐CLPD) is associated with the use of increasingly larger panels of multiple combinations of 3 to ≥6 monoclonal antibodies (Mab), data analysis being separately performed for each of the different stained sample aliquots. Here, we describe and validate an automated method for calculation of flow cytometric data from several multicolor stainings of the same cell sample—i.e., the merging of data from different aliquots stained with partially overlapping combinations of Mab reagents (focusing on ≥1 cell populations)—into one data file as if it concerned a single “super” multicolor staining. Evaluation of the performance of the method described was done in a group of 60 B‐CLPD studied at diagnosis with 18 different reagents in a panel containing six different 3‐ and 4‐color stainings, which systematically contained CD19 for the identification of B‐cells. Our results show a high degree of correlation and agreement between originally measured and calculated data about cell surface stainings, providing a basis for the use of this approach for the generation of flow cytometric data files containing information about a virtually infinite number of stainings for each individual cellular event measured in a sample, using a limited number of fluorochrome stainings. © 2008 International Society for Advancement of Cytometry
Detecting digital image forgeries through inconsistent motion blur (2010)

Fake images have become ubiquitous today in society, as they can be created at the expense of a few clicks using photo manipulation software. The detection of splicing in images has received research attention in recent years. In this paper, we present a novel method of detecting splicing in images, using discrepancies in motion blur. We use motion blur estimation through spectral matting in order to detect inconsistencies between the spliced region and the rest of the image. Experimental results show the effectiveness of our technique. Comparison studies show that this technique performs better than existing blur-based techniques when applied to motion blur.
Intrarater and interrater reliability of three isometric dynamometers in assessing shoulder strength (1996)

The purpose of this study was to evaluate the reliability of three separate isometric strength testing devices. Seventeen (10 female, 7 male) adult volunteers with no known shoulder dysfunction participated. Each subject's internal rotation, external rotation and abduction strength was measured with the Nicholas Manual Muscle Tester (MMT), Biodex Isokinetic Dynamometer, and Isobex 2.0. Two investigators administered the test to each subject with each device. Data were analyzed with intraclass correlation coefficients (ICCs). Ranges of the intrarater intraclass correlation coefficient (3,1) values for each muscle group with each device for both testers were as follows: Nicholas MMT = .84 to .97, Biodex = .97 to .99, and Isobex 2.0 = .95 to .98. Ranges of interrater intraclass correlation coefficient values for each device and muscle group were as follows: Nicholas MMT = .79 to .94, Biodex = .93 to .96, and Isobex 2.0 = .90 to .97. Time to complete testing was shortest for Nicholas MMT, followed by Isobex 2.0, then Biodex. Measurements taken on the same day by the same therapist appear to be highly reliable for all three devices. Measurements taken over a 3-day period by two therapists appear to be highly reliable for all devices and muscle groups with the exception of Nicholas MMT abduction (.79), which was moderately reliable.
Self-Assembled Bilayers from the Protein HFBII Hydrophobin: Nature of the Adhesion Energy (2011)

The hydrophobins are a class of amphiphilic proteins which spontaneously adsorb at the air/water interface and form elastic membranes of high mechanical strength as compared to other proteins. The mechanism of hydrophobin adhesion is of interest for fungal biology and for various applications in electronics, medicine, and food industry. We established that the drainage of free foam films formed from HFBII hydrophobin solutions ends with the appearance of a 6 nm thick film, which consists of two layers of protein molecules, that is, it is a self-assembled bilayer (S-bilayer), with hydrophilic domains pointing inward and hydrophobic domains pointing outward. Its formation is accompanied by a considerable energy gain, which is much greater than that typically observed with free liquid films. The experiments at different pH show that this attraction between the "hydrophilic" parts of the HFBII molecules is dominated by the short-range hydrophobic interaction rather than by the patch-charge electrostatic attraction.
Molecular Cloning of the Human Ryudocan Promoter (1995)

The promoter region of human ryudocan was isolated from a human lambda dash genomic library and cloned into pBluescript. The 5'flanking region contained a classical TATA box and GC rich regions that are commonly found in constitutively expressed genes. Two fusion gene constructs, one of 898 bp and the other of 480 bp of the 5' flanking DNA coupled to the luciferase gene, were transiently expressed in a mouse endothelioma cell line and in human umbilical endothelial cell cultures. Both constructs were capable of driving luciferase expression; the 898 bp construct produced greater levels of luciferase activity than the 480 bp construct in both cell types examined. Analysis of the sequence revealed the presence of several potential sites for nuclear transcription factor binding; the relevance of these sites is presently unknown.
Effect of Spatial Confinement on the Glass-Transition Temperature of Patterned Polymer Nanostructures (2007)

Poly(methyl methacrylate) (PMMA) nanostructures embedded with a fluorescence tag are fabricated using electron beam lithography on oxidized silicon substrates. The glass transition temperatures (Tgs) of these one-dimensional (1-D) nanostructures (parallel lines) are measured by monitoring their temperature-dependent fluorescence intensities, revealing substantial differences between the Tgs of the nanostructures and the thin films from which they were fabricated. For example, the Tg of 50-nm-wide PMMA nanolines on silica is approximately 15 K lower than that of a PMMA film on silica of the same 18 nm thickness. Attractive PMMA-silica interfacial interactions increase the Tg, while free surfaces decrease the Tg of PMMA in ultrathin films relative to bulk PMMA. Thus, the significant differences between the Tgs of the 1-D and two-dimensional (2-D) forms of PMMA on silica are the result of a substantial increase in the ratio of free-surface area to interfacial area in the PMMA nanolines relative to ultrathin films.
Long-Term Results of Cervical Disc Replacement (2014)

Dr. Sundberg is Fellow, Dr. Park is Chief Resident, and Dr. Phillips is Professor, Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St, Suite 300, Chicago, IL 60612; E-mail: [email protected]. All faculty and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations related to this CME activity. The authors have disclosed that use of the Kineflex/C device for cervical disc replacement as discussed in this article has not been approved by the U.S. Food and Drug Administration. Consult the product labeling for approved uses. Lippincott Continuing Medical Education Institute is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Lippincott Continuing Medical Education Institute designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. To earn CME credit, you must read the CME article and complete the quiz and evaluation assessment survey on the enclosed form, answering at least 70% of the quiz questions correctly. This activity expires on November 30, 2015.
Peroxidase‐Catalyzed Polymerization of 1‐Hydroxypyrene (2003)

Abstract Peroxidase‐catalyzed polymerization of a hydroxy substituted polynuclear aromatic compound, 1‐hydroxypyrene, is reported. The fluorescence spectrum of the synthesized polymer shows a dramatic red shift compared to that of the monomer. The enzymatic polymerization of 1‐hydroxypyrene demonstrates the capability of peroxidase in catalyzing the oxidation of polynuclear aromatic molecules, and offers new possibilities for the design and synthesis of polymers with interesting electrical and optical properties in an environmentally friendly way.
Regression and statistical shape model based substitute CT generation for MRI alone external beam radiation therapy from standard clinical MRI sequences (2017)

In MR only radiation therapy planning, generation of the tissue specific HU map directly from the MRI would eliminate the need of CT image acquisition and may improve radiation therapy planning. The aim of this work is to generate and validate substitute CT (sCT) scans generated from standard T2 weighted MR pelvic scans in prostate radiation therapy dose planning. A Siemens Skyra 3T MRI scanner with laser bridge, flat couch and pelvic coil mounts was used to scan 39 patients scheduled for external beam radiation therapy for localized prostate cancer. For sCT generation a whole pelvis MRI (1.6 mm 3D isotropic T2w SPACE sequence) was acquired. Patients received a routine planning CT scan. Co-registered whole pelvis CT and T2w MRI pairs were used as training images. Advanced tissue specific non-linear regression models to predict HU for the fat, muscle, bladder and air were created from co-registered CT-MRI image pairs. On a test case T2w MRI, the bones and bladder were automatically segmented using a novel statistical shape and appearance model, while other soft tissues were separated using an Expectation-Maximization based clustering model. The CT bone in the training database that was most 'similar' to the segmented bone was then transformed with deformable registration to create the sCT component of the test case T2w MRI bone tissue. Predictions for the bone, air and soft tissue from the separate regression models were successively combined to generate a whole pelvis sCT. The change in monitor units between the sCT-based plans relative to the gold standard CT plan for the same IMRT dose plan was found to be [Formula: see text] (mean ± standard deviation) for 39 patients. The 3D Gamma pass rate was [Formula: see text] (2 mm/2%). The novel hybrid model is computationally efficient, generating an sCT in 20 min from standard T2w images for prostate cancer radiation therapy dose planning and DRR generation.
Pharmacology of orismilast, a potent and selective PDE4 inhibitor (2022)

Orismilast displayed selective and potent PDE4 inhibition and broad-spectrum anti-inflammatory activity in several pre-clinical models. The results of the study support clinical development of oral orismilast as a novel treatment option for CISD including psoriasis, atopic dermatitis, and hidradenitis suppurativa.
Data from High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Expression of p95HER2 has been associated with resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Conversely, high levels of HER2 have been linked with increased clinical benefit from anti-HER2 therapy. In this work, we aimed to investigate whether the levels of p95HER2 and HER2 can predict response to anti-HER2 therapy in patients with breast cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We measured p95HER2 and HER2 by VeraTag and HERmark, respectively, in primary tumors of patients enrolled in the neoadjuvant phase III study NeoALTTO and correlated these variables with pathologic complete response (pCR) and progression-free survival (PFS) following lapatinib (L), trastuzumab (T), or the combination of both agents (L+T).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; A positive correlation between p95HER2 and HER2 levels was found in the 274 cases (60%) in which quantification of both markers was possible. High levels of these markers were predictive for pCR, especially in the hormone receptor (HR)–positive subset of patients. High HER2 expression was associated with increased pCR rate upon L+T irrespective of the HR status. To examine whether the levels of either p95HER2 or HER2 could predict for PFS in patients treated with lapatinib, trastuzumab or L+T, we fit to the PFS data in Cox models containing log&lt;sub&gt;2&lt;/sub&gt;(p95HER2) or log&lt;sub&gt;2&lt;/sub&gt;(HER2). Both variables correlated with longer PFS.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Increasing HER2 protein expression correlated with increased benefit of adding lapatinib to trastuzumab. HER2 expression is a stronger predictor of pCR and PFS than p95HER2 for response to lapatinib, trastuzumab and, more significantly, L+T. &lt;i&gt;Clin Cancer Res; 21(3); 569–76. ©2014 AACR.&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Lupus refractory pleural effusion: transient response to intravenous immunoglobulins. (1991)

A patient with systemic lupus erythematosus complicated by refractory bilateral pleural effusions is described. High dose corticosteroids with azathioprine, as well as intrapleural instillation of corticosteroids, proved ineffective in management. As our patient remained severely symptomatic and required repeated thoracocentesis, a therapeutic trial of intravenous immunoglobulins (IVIG) was attempted. IVIG had a beneficial effect, although of a transient and partial nature. Despite the results achieved, it seems that IVIG has limited value in treating lupus pleural effusion.
Utilization of Sequential Palladium-Catalyzed Cross-Coupling Reactions in the Stereospecific Synthesis of Trisubstituted Olefins (2009)

A stereospecific synthesis of the drug-candidate &lt;b&gt;1&lt;/b&gt; is described. The synthetic sequence, aimed at accomplishing modularity and cost savings, features a series of organometallic steps to afford stereospecifically the desired trisubstituded olefin active pharmaceutical ingredient. Key developments consist of a mild Sonogashira reaction of aryl bromide &lt;b&gt;7a&lt;/b&gt; with the polymerization prone propargyl alcohol and a stereospecific hydroalumination, Zn/Al exchange, and Pd-catalyzed cross-coupling sequence facilitated by the commercially available PEPPSI catalyst.