gebhart/patrepeval huggingface dataset:
Intrazeolitic photoinduced redox reactions between tris(2,2'-bipyridine)ruthenium(2+) and methylviologen (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntrazeolitic photoinduced redox reactions between tris(2,2'-bipyridine)ruthenium(2+) and methylviologenPrabir K. Dutta and Wayne TurbevilleCite this: J. Phys. Chem. 1992, 96, 23, 9410–9416Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/j100202a064https://doi.org/10.1021/j100202a064research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Implementation of a geospatial imagery digital library using Java and CORBA (2002)

We have implemented a prototype distributed system for managing and accessing a digital library of geospatial imagery over a wide-area network. The system conforms to a subset of the Geospatial and Imagery Access Services (GIAS) specification from the U.S. National Imagery and Mapping Agency (NIMA), which defines an object-oriented application programming interface (API) using the Common Object Request Broker Architecture (CORBA) for remote access to the image server. The GIAS specification is being explored by the military in both the U.S. and Australia as a means for creating widely accessible imagery repositories, and also provides a convenient API for interfacing to repositories of geospatial images, such as satellite data archives, for a variety of commercial and research applications. Our prototype GIAS implementation was developed using StudioCentral from Silicon Graphics Inc., which provides a set of C++ class libraries for building digital multimedia repositories. We discuss the issues and problems involved in developing this system using CORBA, Java and C++ native methods, within the constraints of the GIAS specification.
Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity (2023)

In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells. However, the role of IRE1/XBP1s in dendritic cells (DCs) in tumors, particularly in conventional type 1 DCs (cDC1s) which are cellular targets in immunotherapy, has not been fully elucidated. Here, we studied the role of IRE1/XBP1s in subcutaneous B16/B78 melanoma and MC38 tumors by generating loss-of-function models of IRE1 and/or XBP1s in DCs or in cDC1s. Data show that concomitant deletion of the RNase domain of IRE1 and XBP1s in DCs and cDC1s does not influence the kinetics of B16/B78 and MC38 tumor growth or the effector profile of tumor infiltrating T cells. A modest effect is observed in mice bearing single deletion of XBP1s in DCs, which showed slight acceleration of melanoma tumor growth and dysfunctional T cell responses, however, this effect was not recapitulated in animals lacking XBP1 only in cDC1s. Thus, evidence presented here argues against a general pro-tumorigenic role of the IRE1/XBP1s pathway in tumor associated DC subsets.
Effect of Ashwagandha Withanolides on Muscle Cell Differentiation (2021)

<i>Withania somnifera</i> (Ashwagandha) is used in Indian traditional medicine, Ayurveda, and is believed to have a variety of health-promoting effects. The molecular mechanisms and pathways underlying these effects have not yet been sufficiently explored. In this study, we investigated the effect of Ashwagandha extracts and their major withanolides (withaferin A and withanone) on muscle cell differentiation using C2C12 myoblasts. We found that withaferin A and withanone and Ashwagandha extracts possessing different ratios of these active ingredients have different effects on the differentiation of C2C12. Withanone and withanone-rich extracts caused stronger differentiation of myoblasts to myotubes, deaggregation of heat- and metal-stress-induced aggregated proteins, and activation of hypoxia and autophagy pathways. Of note, the Parkinson's disease model of Drosophila that possess a neuromuscular disorder showed improvement in their flight and climbing activity, suggesting the potential of Ashwagandha withanolides for the management of muscle repair and activity.
H<inf>∞</inf> control with look-ahead for lane keeping in autonomous vehicles (2017)

In this paper a path tracking control for an autonomous vehicle is developed using the H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> technique. The lateral control problem is reformulated as the control of two variables: the lateral error and the derivative of the look-ahead error, defined as the distance between a virtual point on the vehicle longitudinal axis in front of the CoG and the reference trajectory. This approach is based on the fact that while driving on a constant curvature trajectory the derivative of the look-ahead error must be 0. The effectiveness of the proposed control strategy is demonstrated with experiments on a 2013 Dodge Dart equipped with throttle, brake and steer-by-wire system and in simulation on CarSim. A model of the vehicle is identified, validated by experimental tests and used to tune the simulator. The steering actuator dynamics is also taken into account since it significantly affects the dynamics of the total system.
In Situ Deposition and Patterning of Single‐Walled Carbon Nanotubes by Laminar Flow and Controlled Flocculation in Microfluidic Channels (2005)

Saubere Muster aus einwandigen Kohlenstoffnanoröhren (SWNTs), in denen Dichte und Anordnung eingestellt werden können, wurden mithilfe kontrollierter Koagulation in laminaren Mehrstrom-Mikrofluidiknetzwerken erhalten (siehe Bild). Über die Fluss- und Substratparameter konnten genau definierte SWNT-Muster erzeugt werden.
Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina (2011)

Electrical stimulation threshold and retinal ganglion cell density were measured in a rat model of retinal degeneration. We performed in vivo electrophysiology and morphometric analysis on normal and S334ter line 3 (RD) rats (ages 84-782 days). We stimulated the retina in anesthetized animals and recorded evoked responses in the superior colliculus. Current pulses were delivered with a platinum-iridium (Pt-Ir) electrode of 75-μm diameter positioned on the epiretinal surface. In the same animals used for electrophysiology, SMI-32 immunolabeling of the retina enabled ganglion cell counting. An increase in threshold currents positively correlated with age of RD rats. SMI-32-labeled retinal ganglion cell density negatively correlated with age of RD rats. ANOVA shows that RD postnatal day (P)100 and P300 rats have threshold and density similar to normal rats, but RD P500 and P700 rats have threshold and density statistically different from normal rats (P < 0.05). Threshold charge densities were within the safety limits of Pt for all groups and pulse configurations, except at RD P600 and RD P700, where pulses were only safe up to 1- and 0.2-ms duration, respectively. Preservation of ganglion cells may enhance the efficiency and safety of electronic retinal implants.
Frontiers in Anti-Cancer Drug Discovery: Volume 9 (2018)

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. the Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.
Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity (2011)

In conclusion, epoxygenase activity represents an important endogenous pathway which limits monocyte activation. Moreover endogenous epoxygenases are immuno-modulators regulating monocyte/macrophage activation depending on the underlying activation state.
A 'zero' ripple technique applicable to any DC converter (2003)

Coupled magnetics filter techniques are important tools in a converter designer's arsenal, but are not well understood. Evidence of this is one basic building block of coupled filters, reinvented numerous times during the past 65 years. A detailed analysis of coupled magnetics for DC-DC converters, based on a key building block, is given.
Structure-activity relationships of novel anti-malarial agents: 1. arylacyl and cyclohexylacyl derivatives of 5-amino-2-tolylacetylaminobenzophenone. (2001)

We have identified compound 1 as a lead structure of a novel class of anti-malarial agents. Here, we report on our continuing studies towards the establishment of structure-activity relationships by varying the terminal phenyl moiety and the alkyl linker of the acyl substituent at the 5-amino function of the benzophenone core structure. Most of the derivatives of our lead structure 1 essentially display the same anti-plasmodial activity as the lead.
An assessment of protein–ligand binding site polarizability (2003)

Electronic polarizability, an important physical property of biomolecules, is currently ignored in most biomolecular calculations. Yet, it is widely believed that polarization could account for a substantial fraction of the total nonbonded energy of a system. This belief is supported by studies of small complexes in vacuum. This perception is driving the development of a new class of polarizable force fields for biomolecular calculations. However, the quantification of this term for protein-ligand complexes has never been attempted. Here we explore the polarizable nature of protein-ligand complexes in order to evaluate the importance of this effect. We introduce two indexes describing the polarizability of protein binding sites. These we apply to a large range of pharmaceutically relevant complexes. We offer a recommendation of particular complexes as test systems with which to determine the effects of polarizability and as test cases with which to test the new generation of force fields. Additionally, we provide a tabulation of the amino acid composition of these binding sites and show that composition can be specific for certain classes of proteins. We also show that the relative abundance of some amino acids is different in binding sites than elsewhere in a protein's structure.
Competitive Acetylide C−C Bond Scission vs Formation of a Quadruply Bridging Carbonyl Ligand. X-ray Crystal Structures of the Two Pentanuclear Clusters Cp*3W3Ru2(μ4-C)(μ3-CPh)(CO)9 and Cp*3W3Ru2(μ3-CCBut)(CO)9 (1997)

Reactions of Cp*WRu2(CCPh)(CO)8 (1a) with excess Cp*W(CO)3H, Cp* = C5Me5, affords a carbido−alkylidyne cluster Cp*3W3Ru2(μ4-C)(μ3-CPh)(CO)9 (5) alone with three byproducts, which are identified as hydride cluster Cp*WRu3(μ-H)3(CO)11 (2), vinylidene cluster Cp*2W2Ru2(CCHPh)(CO)9 (4), and a pentanuclear oxo−carbido cluster Cp*2W2(O)Ru3(μ5-C)(CO)11 (3). In contrast, the respective condensation using tert-butyl derivative Cp*WRu2(CCBut)(CO)8 (1b) gives an acetylide cluster Cp*3W3Ru2(μ3-CCBut)(CO)9 (6). The X-ray structural determinations of 5 and 6 reveals the existence of an edge-bridged tetrahedral core, in which the butterfly crater is occupied by a μ4-carbide in 5 or a quadruply bridging CO ligand in 6. A plausible mechanism leading to the formation of these two cluster compounds is also presented.
Device characteristics for poly I<sup>2</sup>L (1977)

Maximizing I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L speed and efficiency while retaining linear-circuit (LIC) compatibility has received little attention; such is the specific goal of Poly I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L [1]. This paper describes the interaction of the Poly NPN and PNP devices with the compatible 15 to 30 volt LIC NPN and lateral PNP devices, and provides processing details. Experimental data is presented demonstrating the non-critical nature of the Poly I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L out-diffused NPN-base scheme. Minimum propagation delay analysis is done showing good agreement with experimental data. Comparable contributions to the ∼5 nsec delay arise from the NPN and the PNP devices, even for ∼7.5 µm PNP base (10 µm layout basewidth). Extrinsic efficiency is dominated by a peripheral component of base-emitter capacitance. The figure of merit [LIC BV <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CBO</inf> /I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L τ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">min</inf> ] is defined and compared for standard and Poly I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L. Finally, it is shown that the previously recognized upper limit on epitaxial resistivity for I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L DC operation does not apply to Poly I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> L.
Structural characterization of avian H5N1 rNA using TEM with single particles reconstruction. (2015)

&lt;p&gt;(A) Typical negative staining TEM image of avian H5N1 rNA. Scale bar corresponds to 200 nm. (B) Representative class averages of avian H5N1 rNa tetramers. Each class average (~50 images per class) contains particles selected from several micrographs and represents the different orientations of the enzyme. Scale bar corresponds to 10 nm. (C) Top (upper panel) and side (lower panel) surface views of the reconstructed avian H5N1 rNA globular head obtained at a resolution of 24 Å (FSC = 0.5).&lt;/p&gt;
Instructional software for visualizing optical phenomena (1997)

We describe a multidisciplinary effort for creating interactive 3D graphical modules for visualizing optical phenomena. These modules are designed for use in an upper-level undergraduate course. The modules are developed in Open Inventor, which allows them to run under both Unix and Windows. The work is significant in that it applies contemporary interactive 3D visualization techniques to instructional courseware, which represents a considerable advance compared to the current state of the practice.
Rotated multi-D constellations in Rayleigh fading: Mutual information improvement and a pragmatic approach for near-capacity performance in high-rate regions (2011)

This paper studies the mutual information improvement attained by rotated multidimensional (multi-D) constellations via a unitary precoder G ∈ C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N×N</sup> in Rayleigh fading. At first, based on the symmetric cut-off rate of the N-D signal space, we develop a design criterion with regard to the precoder G. It is then demonstrated that the use of rotated constellations in only a reasonably low dimensional signal space can significantly increase the mutual information in high-rate regimes. By considering the QPSK system, we then propose a class of good unitary rotation G in 4-D signal space using parameterization approach, which are shown to provide remarkable improvement. To further illustrate the potential of multi-D constellation and to show the practical use of mutual information improvement, we propose a simple yet powerful coded modulation scheme in which a (multi-D) mapping technique employed in a multi-D rotated constellation is concatenated with a short-memory high-rate convolutional code (CC). By using extrinsic information transfer (EXIT) charts, it is demonstrated that the proposed technique provides an exceptionally good error performance. For example, by using the derived 4×4 rotation, together with QPSK constellation, and a simple rate-3/4 outer convolutional code, it is shown that the proposed system can operate 1.39 dB lower than the traditional coded modulation capacity at the bit error rate (BER) level around 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> .
ALLOGENEIC ENDOTHELIUM INDUCES B7-2 EXPRESSION IN TRANSMIGRATING LEUKOCYTES (1998)

430 Vascular endothelial cells (EC) have been shown to play a critical role in the recruitment of leukocytes into inflammatory sites. In addition, allograft EC express MHC class II molecules in vitro and in vivo in acute and chronic rejection. Therefore, it is likely that allograft EC can provide signal 1 to CD4+ T cells as they transmigrate into the graft. However, it is not known whether EC provide the second costimulatory signal via CD28:B7 interactions that is necessary for full CD4+ T cell activation or whether it is provided "in trans" within the graft. We utilized an in vitro transmigration model in which EC were grown to confluence on 8µm pore Transwell membranes to assess the induction of costimulatory molecules on leukocytes following interactions with EC. PBL(5×106), or purified human monocytes (2×106) were added to the upper chamber of transwells and were allowed to transmigrate across unactivated, or TNFα-activated EC. Transmigrated cells were harvested at 6 hrs and were analyzed by semiquantitative RT-PCR for the expression of B7-2. We found that transmigrated PBL or monocytes had a greater than 2 fold induction of B7-2 mRNA. To confirm that EC induction of leukocyte B7-2 involves contact-dependent signals, we generated membrane fractions of TNFα-activated EC by hypotonic lysis of cells and centrifugation. Addition of activated EC membranes from 3×106 EC to monocytes or CD4+ T cells (2×106) for 6 hrs resulted in the induction of B7-2 mRNA and B7-2 protein (by FACS analysis). We next sought to determine whether the B7-2 on infiltrating leukocytes may be functional ("in trans") following partial activation of CD4+ T cells by allogeneic-EC. EC were treated with IFN-γ (1000u/ml) for 48hrs to induce MHC class II expression and were cocultured with unactivated naive CD4+ T cells and B7-2-transfected CHO cells. B7-1 or mock transfected cells were used as a control. EC were irradiated and CHO cells were treated with paraformaldehyde to inhibit proliferation. B7-2- and B7-1-transfected CHO cells but not mock transfected cells enhanced allogeneic-EC mediated CD4+ T cell proliferation and IL-2 production in a dose dependent manner that is inhibited by CTLA4-Ig. Thus, EC may provide signal 1 to CD4+ T cell and in the absence of B7-2 costimulation, they may promote effective costimulationindirectly via the induction of B7-2 on neighboring transmigrating leukocytes. We conclude that allogeneic EC are unique in that they 1) provide signal 1 to transmigrating CD4+ T cells, and 2) modify the phenotype of graft infiltrating leukocytes to provide signal 2 "in trans". Thus, EC may promote persistence of local intragraft CD4+ T cell activation responses.
Optical Flow Estimation Using a Spatial Pyramid Network (2017)

We learn to compute opticalflow by combining a classical spatial-pyramid formulation with deep learning. This estimates large motions in a coarse-to-fine approach by warping one image of a pair at each pyramid level by the current flow estimate and computing an update to the flow. Instead of the standard minimization of an objective function at each pyramid level, we train one deep network per level to compute the flow update. Unlike the recent FlowNet approach, the networks do not need to deal with large motions; these are dealt with by the pyramid. This has several advantages. First, our Spatial Pyramid Network (SPyNet) is much simpler and 96% smaller than FlowNet in terms of model parameters. This makes it more efficient and appropriate for embedded applications. Second, since the flow at each pyramid level is small (<; 1 pixel), a convolutional approach applied to pairs of warped images is appropriate. Third, unlike FlowNet, the learned convolution filters appear similar to classical spatio-temporal filters, giving insight into the method and how to improve it. Our results are more accurate than FlowNet on most standard benchmarks, suggesting a new direction of combining classical flow methods with deep learning.
Robust-to-Dynamics Optimization (2024)

A robust-to-dynamics optimization (RDO) problem is an optimization problem specified by two pieces of input: (i) a mathematical program (an objective function [Formula: see text] and a feasible set [Formula: see text]) and (ii) a dynamical system (a map [Formula: see text]). Its goal is to minimize f over the set [Formula: see text] of initial conditions that forever remain in [Formula: see text] under g. The focus of this paper is on the case where the mathematical program is a linear program and where the dynamical system is either a known linear map or an uncertain linear map that can change over time. In both cases, we study a converging sequence of polyhedral outer approximations and (lifted) spectrahedral inner approximations to [Formula: see text]. Our inner approximations are optimized with respect to the objective function f, and their semidefinite characterization—which has a semidefinite constraint of fixed size—is obtained by applying polar duality to convex sets that are invariant under (multiple) linear maps. We characterize three barriers that can stop convergence of the outer approximations to [Formula: see text] from being finite. We prove that once these barriers are removed, our inner and outer approximating procedures find an optimal solution and a certificate of optimality for the RDO problem in a finite number of steps. Moreover, in the case where the dynamics are linear, we show that this phenomenon occurs in a number of steps that can be computed in time polynomial in the bit size of the input data. Our analysis also leads to a polynomial-time algorithm for RDO instances where the spectral radius of the linear map is bounded above by any constant less than one. Finally, in our concluding section, we propose a broader research agenda for studying optimization problems with dynamical systems constraints, of which RDO is a special case. Funding: O. Günlük was partially supported by the Office of Naval Research [Grant N00014-21-1-2575]. This work was partially funded by the Alfred P. Sloan Foundation, the Air Force Office of Scientific Research, Defense Advanced Research Projects Agency [Young Faculty Award], the National Science Foundation [Faculty Early Career Development Program Award], and Google [Faculty Award].