gebhart/patrepeval huggingface dataset:
Uplink interference protection and fair scheduling for power efficient OFDMA networks (2011)

In this paper a new method for uplink inter-cell interference coordination (ICIC) in a full frequency reuse system is proposed. The technique is named uplink interference protection (ULIP). ULIP exploits existing reference signals transmitted by all base stations (BSs). The fact that path loss and lognormal shadowing can be considered reciprocal in such frequency-division duplex (FDD) systems is exploited. Therefore, no additional signalling is required for a new mobile station (MS) to estimate the level of inter-cell interference it would cause to ongoing uplink transmissions in neighbouring cells. Using the acquired knowledge, MSs can adjust their transmit power to ensure that existing links are not forced into outage. A scheduling scheme is suggested in which a fair allocation of priority resource blocks (RBs), based on user signal-to-interference-plus-noise ratios (SINRs), enhances both cell-edge throughput and user throughput fairness. Through this, also significant system throughput gains are generated. Finally, it is demonstrated that as a side effect of the interference reductions, considerable energy savings can be achieved.
Diagnostic model for pancreatic cancer using a multi-biomarker panel (2021)

This diagnostic model based on the triple ELISA kit showed better diagnostic performance than previous markers for PDAC. In the future, it needs external validation to be used in the clinic.
Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI (2020)

The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multi-ethnic genome-wide association studies.
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics (2021)

White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT dysfunction, obesity, and metabolic complications. However, the mechanisms that retain proper adipose tissue plasticity required for metabolic fitness are unclear. Here, we comprehensively showed that adipocyte-specific DNA methylation, manifested in enhancers and CTCF sites, directs distal enhancer-mediated transcriptomic features required to conserve metabolic functions of white adipocytes. Particularly, genetic ablation of adipocyte Dnmt1, the major methylation writer, led to increased adiposity characterized by increased adipocyte hypertrophy along with reduced expansion of adipocyte precursors (APs). These effects of Dnmt1 deficiency provoked systemic hyperlipidemia and impaired energy metabolism both in lean and obese mice. Mechanistically, Dnmt1 deficiency abrogated mitochondrial bioenergetics by inhibiting mitochondrial fission and promoted aberrant lipid metabolism in adipocytes, rendering adipocyte hypertrophy and WAT dysfunction. Dnmt1-dependent DNA methylation prevented aberrant CTCF binding and, in turn, sustained the proper chromosome architecture to permit interactions between enhancer and dynamin-1-like protein gene <i>Dnm1l</i> (Drp1) in adipocytes. Also, adipose DNMT1 expression inversely correlated with adiposity and markers of metabolic health but positively correlated with AP-specific markers in obese human subjects. Thus, these findings support strategies utilizing Dnmt1 action on mitochondrial bioenergetics in adipocytes to combat obesity and related metabolic pathology.
Pu(V)O2+ Adsorption and Reduction by Synthetic Hematite and Goethite (2005)

Changes in aqueous- and solid-phase plutonium oxidation state were monitored over time in hematite (alpha-Fe2O3) and goethite (alpha-FeOOH) suspensions containing 239Pu(V)-amended 0.01 M NaCl. Solid-phase oxidation state distribution was quantified by leaching plutonium into the aqueous phase and applying an ultrafiltration/solvent extraction technique. The technique was verified using oxidation state analogues of plutonium and sediment-free controls of known Pu oxidation state. Batch kinetic experiments were conducted at hematite and goethite concentrations between 10 and 500 m2 L(-1) in the pH range of 3-8. Surface-mediated reduction of Pu(V) was observed for both minerals at pH values of 4.5 and greater. At pH 3 no adsorption of Pu(V) was observed on either goethite or hematite; consequently, no reduction was observed. For hematite, adsorption of Pu(V) was the rate-limiting step in the adsorption/reduction process. In the pH range of 5-8, the overall removal of Pu(V) from the system (solid and aqueous phases) was found to be approximately second order with respect to hematite concentration and of order -0.39 with respect to the hydrogen ion concentration. The overall reaction rate constant (k(rxn)), including both adsorption and reduction of Pu(V), was 1.75+/-2.05 x 10(-10) (m(-2) L)(-2.08) (mol(-1) L)(-0.39) (s(-1)). In contrast to hematite, Pu(V) adsorption to goethite occurred rapidly relative to reduction. At a given pH,the reduction rate was approximately independent of the goethite concentration, although the hydrogen ion concentration (pH) had only a slight effect on the overall reaction rate. For goethite, the overall reaction rates at pH 5 and pH 8 were 6.0 x 10(-5) and 1.5 x 10(-4) s(-1), respectively. For hematite, the reaction rate increased by 3 orders of magnitude across the same pH range.
Thin‐film transistor mobility limits considerations (2016)

Abstract The mobility limiting scattering mechanisms for amorphous semiconductors and polar polycrystalline semiconductors are studied in the context of developing new high‐performance thin‐film transistor (TFT) channel layer materials for large‐area electronics. A physics‐based model for carrier transport in an amorphous semiconductor is developed to estimate the mobility limits of amorphous semiconductor TFTs. The model involves band tail state trapping of a diffusive mobility. Simulation reveals a strong dependence on the band tail density of states. This consideration makes it difficult to realize a high‐performance p‐type oxide TFT. A polar crystalline semiconductor may offer a higher mobility but is fundamentally limited by polar optical phonon scattering. Any crystalline TFT channel layer for practical large‐area applications will not be a single crystal but polycrystalline, and therefore, grain size and grain boundary‐dependent scattering will further degrade the transport properties.
Cycle-Accurate Network on Chip Simulation with Noxim (2016)

The on-chip communication in current Chip-MultiProcessors (CMP) and MultiProcessor-SoC (MPSoC) is mainly based on the Network-on-Chip (NoC) design paradigm. Unfortunately, it is foreseen that conventional NoC architectures cannot sustain the performance, power, and reliability requirements demanded by the next generation of manycore architectures. Recently, emerging on-chip communication technologies, like wireless Networks-on-Chip (WiNoCs), have been proposed as candidate solutions for addressing the scalability limitations of conventional multi-hop NoC architectures. In a WiNoC, a subset of network nodes are equipped with a wireless interface which allows them long-range communication in a single hop. Assessing the performance and power figures of NoC and WiNoC architectures requires the availability of simulation tools that are often limited on modeling specific network configurations. This article presents Noxim, an open, configurable, extendible, cycle-accurate NoC simulator developed in SystemC, which allows to analyze the performance and power figures of both conventional wired NoC and emerging WiNoC architectures.
Supplementary Table S1 from High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab (2023)

&lt;p&gt;Supplementary Table S1. Multivariate Models in the IHC 3+ Subgroup&lt;/p&gt;
Learning a Generative Motion Model from Image Sequences based on a Latent Motion Matrix (2020)

We propose to learn a probabilistic motion model from a sequence of images for spatio-temporal registration. Our model encodes motion in a low-dimensional probabilistic space - the motion matrix - which enables various motion analysis tasks such as simulation and interpolation of realistic motion patterns allowing for faster data acquisition and data augmentation. More precisely, the motion matrix allows to transport the recovered motion from one subject to another simulating for example a pathological motion in a healthy subject without the need for inter-subject registration. The method is based on a conditional latent variable model that is trained using amortized variational inference. This unsupervised generative model follows a novel multivariate Gaussian process prior and is applied within a temporal convolutional network which leads to a diffeomorphic motion model. Temporal consistency and generalizability is further improved by applying a temporal dropout training scheme. Applied to cardiac cine-MRI sequences, we show improved registration accuracy and spatio-temporally smoother deformations compared to three state-of-the-art registration algorithms. Besides, we demonstrate the model's applicability for motion analysis, simulation and super-resolution by an improved motion reconstruction from sequences with missing frames compared to linear and cubic interpolation.
Application of the cost-per-good-die metric for process design co-optimization (2010)

The semiconductor industry has pursued a rapid pace of technology scaling to achieve an exponential component cost reduction. Over the years the goal of technology scaling has been distilled down to two discrete targets. Process engineers focus on sustaining wafer costs, while manufacturing smaller dimensions whereas design engineers work towards creating newer IC designs that can feed the next generation of electronic products. In doing so, the impact of process choices made by manufacturing community on the design of ICs and vice-versa were conveniently ignored. Hoever, with the lack of cost effective lithography solutions at the forefront, the process and design communities are struggling to minimize IC die costs by following the described traditional scaling practices. In this paper we discuss a framework for quantifying the economic impact of design and process decisions on the overall product by comparing the cost-per-good-die. We discuss the intricacies involved in computing the cost-per-good-die as we make design and technology choices. We also discuss the impact of design and lithography choices for the 32nm and 22nm technology node. The results demonstrate a strong volume dependence on the optimum design style and corresponding lithography and strategy. Most importantly, using this framework process and design engineers can collaborate to define design style and lithography solutions that will lead to continued IC cost scaling.
Integrated display scanner (2023)

A display scanner includes an optical panel having a plurality of stacked optical waveguides. The waveguides define an inlet face at one end and a screen at an opposite end, with each waveguide having a core laminated between cladding. A projector projects a scan beam of light into the panel inlet face for transmission from the screen as a scan line to scan a barcode. A light sensor at the inlet face detects a return beam reflected from the barcode into the screen. A decoder decodes the return beam detected by the sensor for reading the barcode. In an exemplary embodiment, the optical panel also displays a visual image thereon.
Transport in a partially open porous media flow (2007)

In nature dissipative fluxes of fluid, heat, and/or reacting species couple to each other and may also couple to deformation of a surrounding porous matrix. We use the well-known analogy of Hele-Shaw flow to Darcy flow to make a model porous medium with porosity proportional to local cell height. Time- and space-varying fluid injection from multiple source/sink wells lets us create many different kinds of chaotic flow and chemical concentration patterns. Results of an initial time-dependent potential flow model illustrate that this is a partially open flow, in which parts of the flow remain in the cell forever and parts pass through with residence time and exit time distributions that have self-similar features in the control parameter space of the stirring.
Vacuum exhausted isolation locker (VEIL) to reduce inpatient droplet/aerosol transmission during COVID-19 pandemic (2021)

The vacuum-exhausted isolation locker (VEIL) provides a safety barrier during the care of COVID-19 patients. The VEIL is a 175-L enclosure with exhaust ports to continuously extract air through viral particle filters connected to hospital suction. Our experiments show that the VEIL contains and exhausts exhaled aerosols and droplets.
Evaluation of ESD hardness for fingerprint sensor LSIs (2004)

We evaluated the electrostatic discharge (ESD) hardness for some kinds of capacitive fingerprint sensor LSIs. In contact discharge tests, our sensor with the GND wall structure and another sensor with a GND demonstrated of ESD failure voltage above plusmn8 kV. On the other hand, in air discharge tests, ESD tolerance of our GND wall structure was over plusmn 20 kV, whereas that of the other GND structure was below plusmn 12 kV. It is evident from our findings that ESD immunity in the sensor LSIs obviously depends on the GND structure and our sensor LSI with the GND wall has the highest ESD tolerance.
Creation of chiral structures inside fused silica glass (2008)

Circularly polarized (CP) femtosecond laser light focused into fused silica produces a permanent recording of optical helicity. Material modification is in the form of highly ordered submicrometer chiral structures whose handedness follows the handedness of the CP light. The evolution of the ordered structures from chaotic modification is described.
Transoral Robotic Surgery for Advanced Oropharyngeal Carcinoma (2010)

This novel transoral robotic surgery treatment regimen offers disease control, survival, and safety commensurate with standard treatments and an unexpected beneficial outcome of gastrostomy dependency rates that are markedly lower than those reported with standard nonsurgical therapies.
Current Programmed Mode Control of Multi-Level Flying Capacitor Converter Near Zero-Ripple Current Region (2019)

This paper explores the challenges and introduces a solution for near zero-ripple current region operation of multilevel flying capacitor (ML-FC) converters, operating in peak and valley current programmed mode (CPM). Around the zero-ripple region, the triangular inductor current ripple waveform is modified to be trapezoidal using a state machine. Seamless transition between peak and valley is desirable to ensure symmetrical stable operation below and above the duty-cycle yielding zero-ripple current. In both cases, flying capacitor voltage inherent stabilization is achieved. The investigated ideas are verified with a three-level FC buck converter with 5 V output operating at 500 kHz nominal switching frequency near 50% duty-cycle, the zero-ripple current region.
A bimetal and electret-based converter for thermal energy harvesting (2012)

This paper presents a new device able to turn thermal gradients into electricity by using a bimetal-based heat engine coupled to an electrostatic converter. A two-steps conversion is performed: (i) a curved bimetallic strip turns the thermal gradient into a mechanical movement (thermal-to-mechanical conversion) that is (ii) then converted into electricity thanks to an electret-based electrostatic converter (mechanical-to-electrical conversion). An output power up to 5.5uW on a hot source at 50°C has already been reached, validating this new concept.
Late effects of childhood cancer treatment in long-term survivors diagnosed before the age of 3 years – A multicenter, nationwide study (2022)

This study confirms that radiotherapy and some specific toxicity of cytostatics are the most important factors affecting organ function. Apart from a higher incidence of liver dysfunction in the youngest patients, there were no significant differences in organ and system toxicities between children diagnosed under the age of 1 and those diagnosed at the age of 1-3. We have shown that this group requires systematic, careful and long-term follow-up.
Spontaneous Intracranial Hypotension May Be an Under-recognized Cause of Endolymphatic Hydrops (2020)

SIH may be an under-recognized cause of EH. We support the theory that negative intracranial pressure transmitted through the cochlear aqueduct and perilymph leads to EH. Despite the variations in treatments, the overall prognosis is excellent.
Green’s function for steady flow over a small two-dimensional topography (2000)

We consider steady flow of a thin viscous liquid film over a small two-dimensional topography and develop a Green’s function for the linearized problem. The solutions so obtained can be used to analyze the effect of arbitrary small substrate defects on the coating applied to a substrate.
Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate (2012)

Hepatitis C virus (HCV) is present in the host with multiple variants generated by its error prone RNA-dependent RNA polymerase. Little is known about the initial viral diversification and the viral life cycle processes that influence diversity. We studied the diversification of HCV during acute infection in 17 plasma donors, with frequent sampling early in infection. To analyze these data, we developed a new stochastic model of the HCV life cycle. We found that the accumulation of mutations is surprisingly slow: at 30 days, the viral population on average is still 46% identical to its transmitted viral genome. Fitting the model to the sequence data, we estimate the median in vivo viral mutation rate is 2.5×10⁻⁵ mutations per nucleotide per genome replication (range 1.6-6.2×10⁻⁵), about 5-fold lower than previous estimates. To confirm these results we analyzed the frequency of stop codons (N = 10) among all possible non-sense mutation targets (M = 898,335), and found a mutation rate of 2.8-3.2×10⁻⁵, consistent with the estimate from the dynamical model. The slow accumulation of mutations is consistent with slow turnover of infected cells and replication complexes within infected cells. This slow turnover is also inferred from the viral load kinetics. Our estimated mutation rate, which is similar to that of other RNA viruses (e.g., HIV and influenza), is also compatible with the accumulation of substitutions seen in HCV at the population level. Our model identifies the relevant processes (long-lived cells and slow turnover of replication complexes) and parameters involved in determining the rate of HCV diversification.
Elevated Frequency of Gamma Interferon-Producing NK Cells in Healthy Adults Vaccinated against Influenza Virus (2007)

Recent studies indicate that innate immunity in influenza virus infection is an area of substantial importance for our understanding of influenza virus pathogenesis, yet our knowledge of the mechanisms controlling innate immunity remains limited. Further delineation of the roles of NK cells and innate immunity in viral infection may have important implications for the development of improved influenza virus vaccines. In this study, we evaluated the phenotype and function of NK and T lymphocytes, as well as influenza virus-specific immunoglobulin G production, prior to and following vaccination with the routinely administered trivalent influenza virus vaccine. We demonstrate influenza virus antigen-specific innate and adaptive cellular responses and evaluate changes in NK cell receptor expression over time. Our results demonstrate increased innate and adaptive cellular immune responses and show that NK cells are a significant source of gamma interferon (IFN-gamma) following influenza virus vaccination. An increase in the frequency of IFN-gamma-producing NK cells was observed in many subjects postvaccination. The subset distribution with respect to CD56(dim) and CD56(bright) NK cell subsets remained stable, as did the NK cell phenotype with respect to expression of cell surface activating and inhibitory receptors. These results may form the basis for further investigations of the role of NK cells in immunity to influenza.
Adenomatous Polyposis Families That Screen APC Mutation–Negative by Conventional Methods Are Genetically Heterogeneous (2005)

Purpose One third of families with classical adenomatous polyposis (FAP), and a majority of those with attenuated FAP (AFAP), remain APC mutation–negative by conventional methods. Our purpose was to clarify the genetic basis of polyposis and genotype-phenotype correlations in such families. Patients and Methods We studied a cohort of 29 adenomatous polyposis families that had screened APC mutation–negative by the protein truncation test, heteroduplex analysis, and exon-specific sequencing. The APC gene was investigated for large genomic rearrangements by multiplex ligation-dependent probe amplification (MLPA), and for allelic mRNA expression by single nucleotide primer extension (SNuPE). The AXIN2 gene was screened for mutations by sequencing. Results Four families (14%) showed a constitutional deletion of the entire APC gene (three families) or a single exon (one family). Seven families (24%) revealed reduced or extinct mRNA expression from one APC allele in blood, accompanied by loss of heterozygosity in the APC region in six (75%) of eight tumors. In 15 families (52%), possible APC involvement could be neither confirmed nor excluded. Finally, as detailed elsewhere, three families (10%) had germline mutations in genes other than APC, AXIN2 in one family, and MYH in two families. Conclusion “APC mutation–negative” FAP is genetically heterogeneous, and a combination of MLPA and SNuPE is able to link a considerable proportion (38%) to APC. Significant differences were observed in clinical manifestations between subgroups, emphasizing the importance of accurate genetic and clinical characterization for the proper management of such families.
Ion voltage diagnostics in the far-field plume of a high-specific impulse Hall thruster (2003)

Peer Reviewed
New Laser Labeling Technology for Recordable Digital Versatile Disc (2007)

A new labeling technology, i.e., "LabelflashTM", is reported. This technology uses the digital versatile disc (DVD) drive data recording head to burn high-quality images directly into a specialized dye layer on the label side of DVD discs. The basic structure of the disc is similar to a conventional double-sided recordable digital versatile disc (DVD-R). Consequently, a Labelflash disc shows various features as follows: non consumable, no special optical path or drive control system, the same working distance as that for data recording, manufactured using conventional equipment for double-sided DVD-R, fast drawing speed, high durability, and professional appearance. Moreover, four color variation types and mat-type discs were developped. The graphic quality performance index for Labelflash was newly proposed. The values were closely matched by the subjective evaluations of contrast.