gebhart/patrepeval huggingface dataset:
In Situ Synthesis of Porous Silicon Carbide (SiC) Ceramics Decorated with SiC Nanowires (2007)

We fabricated highly aligned porous silicon carbide (SiC) ceramics decorated with SiC nanowires by the unidirectional freeze casting of SiC/camphene slurries with various polycarbosilane (PCS) contents, ranging from 0 to 20 wt% in relation to the SiC powders, in which the PCS preceramic was used as a binder and source for the in situ growth of the SiC nanowires. In this method, aligned pore channels were formed as a replica of the unidirectionally grown camphene dendrites, while SiC nanowires were formed within the pores in situ via a vapor–liquid–solid (VLS) mechanism during the heat treatment of the porous green bodies at 1400°C for 1 h in a flowing Ar atmosphere. The pore channels were well decorated with single‐crystalline SiC nanowires. It was also observed that the growth of the SiC nanowires was strongly affected by the initial PCS content and heat‐treatment temperature.
Word Recognition Clinical Testing of Personalized Deep Reinforcement Learning Compression (2020)

Current hearing aid fittings are carried out using prescriptive compression settings. These settings are derived from group averages but do not account for individual differences or preferences. In a previous work, we developed a human-in-the-loop deep reinforcement learning compression approach to set the compression ratios across a number of frequency bands. These compression ratios were compared to those of the widely used and accepted DSL-v5 hearing aid prescription to determine if incorporating user preference impacted word recognition performance. A pilot clinical study of this comparison for four participants is reported in this paper. The clinical testing results obtained strongly support the hypothesis that the personalized compression settings do not negatively impact word recognition or audibility compared to the prescriptive compression settings. The ability to provide a personalized amplification strategy with no degradation in hearing performance would be of benefit in hearing aids or other assistive listening technologies.
Identification of interleukin 8 as an inhibitor of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in the ovarian carcinoma cell line OVCAR3. (2003)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to trigger apoptosis in many malignant cells. Whereas cancer cells are responsive to TRAIL-induced cell death when used alone or in combination with other agents, normal cells are known to be relatively less sensitive to the ligand, making it a desirable therapeutic compound to target a variety of cancers. TRAIL induces apoptosis through its interaction with its two proapoptotic death receptors (DRs), DR4 and DR5. In addition, it may also bind the decoy receptors (DcRs), DcR1 and DcR2, which lack an intracellular signaling domain, thus negatively regulating TRAIL-induced apoptosis. Previously, it has been shown that interleukin (IL)-8 is elevated in the ascites of patients with ovarian cancer. Therefore, we examined the role that IL-8 may play in modulating sensitivity to TRAIL-mediated apoptosis. We treated the TRAIL-sensitive cell line OVCAR3 with TRAIL over a period of time with or without pretreatment with IL-8. Here we show the novel findings that IL-8 blocks TRAIL-induced cell death and was able to turn the TRAIL-sensitive cell line into a TRAIL-resistant one. We hypothesized that decreased expression of DRs DR4 and DR5 may contribute to TRAIL resistance. Both reverse transcription-PCR and flow cytometry revealed a decrease in DR4 expression after pretreatment of OVCAR3 cells with IL-8. We have also shown that TRAIL was able to induce caspase-8 cleavage in these cells, whereas pretreatment with IL-8 blocked this caspase cleavage. Through array analysis and confirmation with other techniques, we have determined that IL-8 regulates the expression of a member of the mitogen-activated protein kinase superfamily, p38gamma. These findings provide important insights into the modulation of apoptosis by TRAIL and IL-8 in ovarian cancer. The data suggest a potentially important role of IL-8 in protecting ovarian cancer cells from TRAIL-mediated apoptosis and signify a new potential chemotherapeutic target to augment TRAIL therapy.
Table S1 from Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts (2023)

&lt;p&gt;Percentage change in tumor volume in PDX per treatment and relevant PI3K/AKT/mTOR-pathway and TP53 mutations in PDX models&lt;/p&gt;
Novel Pyrazine Amide Compounds (2015)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTNovel Pyrazine Amide CompoundsBenjamin Blass*View Author Information Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States*Tel: 215-707-1085. E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2015, 6, 7, 729–731Publication Date (Web):June 8, 2015Publication History Received6 May 2015Published online8 June 2015Published inissue 9 July 2015https://pubs.acs.org/doi/10.1021/acsmedchemlett.5b00186https://doi.org/10.1021/acsmedchemlett.5b00186editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views896Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (247 KB) Get e-AlertscloseSUBJECTS:Amides,Anions,Elements,Sodium,Substituents Get e-Alerts
The effects of manuka honey on plaque and gingivitis: a pilot study. (2004)

These results suggest that there may be a potential therapeutic role for manuka honey confectionery in the treatment of gingivitis and periodontal disease.
Spatiotemporal dynamics of word retrieval in speech production revealed by cortical high-frequency band activity (2017)

Word retrieval is core to language production and relies on complementary processes: the rapid activation of lexical and conceptual representations and word selection, which chooses the correct word among semantically related competitors. Lexical and conceptual activation is measured by semantic priming. In contrast, word selection is indexed by semantic interference and is hampered in semantically homogeneous (HOM) contexts. We examined the spatiotemporal dynamics of these complementary processes in a picture naming task with blocks of semantically heterogeneous (HET) or HOM stimuli. We used electrocorticography data obtained from frontal and temporal cortices, permitting detailed spatiotemporal analysis of word retrieval processes. A semantic interference effect was observed with naming latencies longer in HOM versus HET blocks. Cortical response strength as indexed by high-frequency band (HFB) activity (70-150 Hz) amplitude revealed effects linked to lexical-semantic activation and word selection observed in widespread regions of the cortical mantle. Depending on the subsecond timing and cortical region, HFB indexed semantic interference (i.e., more activity in HOM than HET blocks) or semantic priming effects (i.e., more activity in HET than HOM blocks). These effects overlapped in time and space in the left posterior inferior temporal gyrus and the left prefrontal cortex. The data do not support a modular view of word retrieval in speech production but rather support substantial overlap of lexical-semantic activation and word selection mechanisms in the brain.
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules (2009)

Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
CILAB – ein PC-basierter Laborsprachprozessor zur Implementierung und Evaluierung neuer Stimulationsstrategien für Cochlea-Implantate / CILAB – a PC Based Laboratory Sound Processor for Cochlear Implants (2004)

CILab is a computer-based versatile laboratory system for the implementation and evaluation of innovative stimulation strategies for cochlear implants. In contrast to existing laboratory systems the entire signal processing from the input signal to the creation of the data word for the implant is effected with the aid of a personal computer (PC). This permits rapid implementation of new stimulation strategies or psycho-acoustic tests. Real-time audio processing is also possible by using the CILab as a cochlear implant speech processor. The laboratory system has been employed with success for the evaluation of new strategies and numerous psycho-acoustic tests.
Loosely Coupled Transformer Structure and Interoperability Study for EV Wireless Charging Systems (2015)

As the wireless power transfer (WPT) technology has been proved to be a convenient and reliable charging method to plug-in hybrid electric vehicles and electric vehicles, the loosely coupled transformer structure and size are the primary and fundamental concern to design an efficient WPT system. In this paper, a double D (DD) coil and a unipolar coil are selected to conduct the study. We focus on the coil structure design to achieve the maximum coupling coefficient as well as efficiency with two situations: 1) with no misalignment, and 2) with a 75-mm door-to-door and 100-mm front-to-back misalignment at which the maximum operating capability can still be achieved. A coil size optimization process is proposed for both the DD coil and the unipolar coil configurations. The relationship between the size of the secondary (receiving) coil, which determines the weight of the pad on the vehicle, and achievable maximum efficiency is studied for both coil topologies. The interoperability between the two coil topologies is studied. The proposed transformer structures with aluminum shielding meet human exposure regulations of the International Commission on Non-Ionizing Radiation Protection guidelines as a foundation. Finally, experiments validated the analyses.
ChemInform Abstract: Synthesis and Antimetastatic Activity of L‐Iduronic Acid‐Type 1‐N‐ Iminosugars. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data Supplement from A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets (2023)

&lt;p&gt;Supplementary Table S3. Proteomic analysis of CT antigens in 38 NSCLC cell lines.&lt;/p&gt;
X-ray photoemission spectra of reactively sputtered TiN (1992)

X-ray photoemission spectra of reactively sputtered TiN1.0 films are recorded without interference from adsorbed contaminants or ion sputter cleaning damage. In this way, the transition from hcp TiN0.3 to fcc TiN1.0 is characterized by a discontinuity in film stoichiometry, Ti 2p splitting energy, and Ti 2p3/2 binding energy as a function of the Ar/N2 ratio during sputtering. The line shapes of the N 1s and 2s transitions experience only an asymmetric broadening on forming fcc TiN. The core-level N 1s transition of fcc TiN is modeled as two components peaks with binding energies at 396.8 and 396.0 eV. Similarly, the valence band N 2s transition has corresponding component peaks at 16.8 and 16.2 eV. These high and low binding energy pairs are interpreted as on-site Ns and interstitial site Ni populations of nitrogen in a fcc TiN lattice, respectively. The ratio of N/Ti is 1.0 and the Ns/Ni ratio is approximately 6. Both ratios are independent of the composition of the sputtering gas mixture and the substrate temperature once fcc TiN is formed. The core level Ti 2p transition in fcc TiN is characteristic of a single Ti3+ oxidation state with a line shape that is also insensitive to the gas composition and the substrate temperature during sputtering.
EVALUATING THE IMPACT OF A MULTIDISCIPLINARY SINGLE DAY CLINIC ON THE MANAGEMENT OF PANCREATIC CANCER (2007)

Purpose: For cancer treatment, a multidisciplinary model has become popular over the past ten years. Johns Hopkins Hospital (JHH) offers a single day comprehensive evaluation of a patient incorporating education, diagnosis, treatment, and research of pancreatic cancer by clinicians and specialists. The purpose of the study was to evaluate the impact of this approach on the management of pancreatic cancer. Methods: The medical records of 144 consecutive patients self and physician-referred to JHH's Pancreatic Multidisciplinary Cancer Clinic (PMDCC) were prospectively collected over a 9-month period. If necessary, new laboratory studies and radiologic scans were obtained at JHH the morning of the clinic. Available radiologic data, pathologic data, and medical histories were then evaluated by a panel of diagnostic radiologist, pathologist, geneticist, and medical, radiation, and surgical oncologists. After a consensus was reached, patients were subsequently seen by each specialty. Diagnosis, radiologic, pathologic, and surgical data were retrospectively compared before and after the PMDCC to determine if specific interpretations altered patient management. Results: Overall, 24% of all patients had a change in the management of their cancer following the PMDCC review. 16 patients had a change in diagnosis due to radiologic and pathologic review (11%). 20 patients had a change in cancer status (14%). 50 patients had a change in the interpretation of available scans or biopsies (35%). 14 patients had change in the resectability statusof their tumor (16%). Overall, 6 patients had pathologic interpretation changes in terms of tumor grade, subtype, and margin status. Enrollment into the National Familial Pancreatic Tumor Registry increased from 52 out of 106 (49%) to 158 out of 220 patients (72%) when compared to the previous year. Conclusions: The single day pancreatic multidisciplinary cancer clinic provided efficient and integrated evaluation that led to changes in cancer care management in 24% of (35 out of 144) patients.
Impact of Melanin on Microbial Virulence and Clinical Resistance to Antimicrobial Compounds (2006)

Melanins are negatively charged, hydrophobic pigments of high molecular weight ([54][1], [88][2], [95][3], [139][4]) that are composed of polymerized phenolic and/or indolic compounds (Fig. [1][5]) ([45][6], [128][7]). Melanins are produced by organisms in all biological kingdoms, including a wide
The Solar Orbiter EUI instrument: The Extreme Ultraviolet Imager (2020)

Context. The Extreme Ultraviolet Imager (EUI) is part of the remote sensing instrument package of the ESA/NASA Solar Orbiter mission that will explore the inner heliosphere and observe the Sun from vantage points close to the Sun and out of the ecliptic. Solar Orbiter will advance the “connection science” between solar activity and the heliosphere. Aims. With EUI we aim to improve our understanding of the structure and dynamics of the solar atmosphere, globally as well as at high resolution, and from high solar latitude perspectives. Methods. The EUI consists of three telescopes, the Full Sun Imager and two High Resolution Imagers, which are optimised to image in Lyman- α and EUV (17.4 nm, 30.4 nm) to provide a coverage from chromosphere up to corona. The EUI is designed to cope with the strong constraints imposed by the Solar Orbiter mission characteristics. Limited telemetry availability is compensated by state-of-the-art image compression, onboard image processing, and event selection. The imposed power limitations and potentially harsh radiation environment necessitate the use of novel CMOS sensors. As the unobstructed field of view of the telescopes needs to protrude through the spacecraft’s heat shield, the apertures have been kept as small as possible, without compromising optical performance. This led to a systematic effort to optimise the throughput of every optical element and the reduction of noise levels in the sensor. Results. In this paper we review the design of the two elements of the EUI instrument: the Optical Bench System and the Common Electronic Box. Particular attention is also given to the onboard software, the intended operations, the ground software, and the foreseen data products. Conclusions. The EUI will bring unique science opportunities thanks to its specific design, its viewpoint, and to the planned synergies with the other Solar Orbiter instruments. In particular, we highlight science opportunities brought by the out-of-ecliptic vantage point of the solar poles, the high-resolution imaging of the high chromosphere and corona, and the connection to the outer corona as observed by coronagraphs.
Growth and Transport Studies in M/I/$p$-SC Magnetic Tunnel Diodes Containing Different Tunnel Barrier Materials (2007)

Metal-insulator-semiconductor (MIS) magnetic tunnel diodes consisting of ferromagnetic metal (Fe) and semiconductor (Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Mn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> As) electrodes with various tunnel barrier materials (AlAs, GaAs, ZnTe, and MgO) were fabricated. A clear tunneling magnetoresistance (TMR) effect was observed in all the samples. Magnetoresistance ratios at 2 K were observed to be 38% for AlAs, 11% for GaAs, 8% for ZnTe, and ~1% for MgO. Growth and transport studies strongly suggested that the small lattice mismatch between the barrier and the electrode materials and Mn-free interfaces are important for have significant influence on developing high-quality MIS magnetic tunnel diodes.
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. (1992)

Structural mitochondrial damage accompanies the cytotoxic effects of several drugs including tumor necrosis factor (TNF). Using various inhibitors of mitochondrial electron transport we have investigated the mechanism of TNF-mediated cytotoxicity in L929 and WEHI 164 clone 13 mouse fibrosarcoma cells. Inhibitors with different sites of action modulated TNF cytotoxicity, however, with contrasting effects on final cell viability. Inhibition of mitochondrial electron transport at complex III (cytochrome c reductase) by antimycin A resulted in a marked potentiation of TNF-mediated injury. In contrast, when the electron flow to ubiquinone was blocked, either at complex I (NADH-ubiquinone oxidoreductase) with amytal or at complex II (succinate-ubiquinone reductase) with thenoyltrifluoroacetone, cells were markedly protected against TNF cytotoxicity. Neither uncouplers nor inhibitors of oxidative phosphorylation nor complex IV (cytochrome c oxidase) inhibitors significantly interfered with TNF-mediated effects, ruling out the involvement of energy-coupled phenomena. In addition, the toxic effects of TNF were counteracted by the addition of antioxidants and iron chelators. Furthermore, we analyzed the direct effect of TNF on mitochondrial morphology and functions. Treatment of L929 cells with TNF led to an early degeneration of the mitochondrial ultrastructure without any pronounced damage of other cellular organelles. Analysis of the mitochondrial electron flow revealed that TNF treatment led to a rapid inhibition of the mitochondria to oxidize succinate and NADH-linked substrates. The inhibition of electron transport was dose-dependent and became readily detectable 60 min after the start of TNF treatment, thus preceding the onset of cell death by at least 3-6 h. In contrast, only minor effects were observed on complex IV activity. The different effects observed with the mitochondrial respiratory chain inhibitors provide suggestive evidence that mitochondrial production of oxygen radicals mainly generated at the ubisemiquinone site is a causal mechanism of TNF cytotoxicity. This conclusion is further supported by the protective effect of antioxidants as well as the selective pattern of damage of mitochondrial chain components and characteristic alterations of the mitochondrial ultrastructure.
Supplementary Movie S3. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity (2023)

&lt;p&gt;Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MDA-MB-231 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 2 hours. Time lapse movies were assembled from the Z stacks in NIH ImageJ and played at a fast frame rate (5 frames per second). NK cells are stained in red (PKH26) whereas the LifeAct-mEGFP-expressing tumour cell appears in green.&lt;/p&gt;
O-Linked fucose and other post-translational modifications unique to EGF modules (1993)

Three types of unusual post-translational modification have been found within conserved amino acid sequences in epidermal growth factor homology regions (EGF modules) of some multidomain proteins. beta-Hydroxyaspartate and beta-hydroxyasparagine are found within -Cys-Xxx-Asp/Asn-Xxx-Xxx-Xxx-Xxx-Tyr/Phe-Xxx-Cys-Xxx-Cys- sequences. (Xyl alpha 1-->3)Xyl alpha 1-->3Glc beta 1-->O-Ser glycans at conserved sites within -Cys-Xxx-Ser-Xxx-Pro-Cys- sequences have been reported in several proteins. Fuc alpha 1-->O-Thr/Ser modifications have been found at conserved sites within -Cys-Xxx-Xxx-Gly-Gly-Thr/Ser-Cys- sequences. More recently, it has been discovered that the Ser residue corresponding to the potential O-fucosylation site in human factor IX carries the novel tetrasaccharide NeuAc alpha 2-->6Gal beta 1-->4GlcNAc beta 1-->3Fuc alpha 1-->O-Ser; this tetrasaccharide can be considered to be an extension of the Fuc alpha 1-->O moiety. The consensus sequences for these post-translational modifications are in close proximity to each other; e.g. human factor IX has all three unusual modifications within a 12 amino acid linear sequence. In proteins with multiple EGF modules, the O-glycosidic modifications have been found only within the N-terminal EGF module; beta-hydroxyaspartate/asparagine residues are not restricted in the same fashion. Little is known yet about the functions of, or possible relationships between, any of these modifications.
Dedication (2014)

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