gebhart/patrepeval huggingface dataset:
Effect of Chromium Content on Relationship Between r-value and {111} Recrystallization Texture in Ferritic Steel (2003)

The deep drawability of ferritic steels can be improved by increasing the r-value, which is closely related to the {111} recrystallization texture. Control of the {111} recrystallization texture in ferritic steel has been extensively studied as the means of improving the deep drawability of the steel sheet. However, no published research has compared the relationship between the r-value and {111} recrystallization texture in mild steels and ferritic stainless steels.The aim of the present research is to clarify the effect of chromium on the relationship between the {111} recrystallization texture and r-value in order to improve the deep drawability of ferritic stainless steels.The following results were obtained through the study using body-centered cubic steels with various chromium content: (1) Ferritic stainless steels show higher r-values than mild steels with the same level of {111} recrystallization texture. (2) Chromium addition is advantageous for realizing higher r-values in ferritic steel.The authors propose that some slip systems in ferritic steels are constrained by chromium atoms, which results in higher r-values in ferritic steels.
Percutaneous drainage of subphrenic abscesses (1989)

Abstract Forty subphrenic abscesses were drained percutaneously in 37 patients. These abscesses were subsequent to abdominal surgery (28 patients), biliary obstruction and/or fistula (six patients), trauma (two patients) or acute pancreatitis (one patient). The procedures were usually monitored by duplex sonography and fluoroscopy (35 out of 40 cases), with an angled subcostal approach to the subphrenic space in over 85% of the cases. Forty-three drainage catheters were inserted using the Seldinger method; 37 (86%) had a size of 12 F or more, 21 were 16 F in size. Only two out of 43 catheters were double-lumen sump drains. The clinical condition improved after insertion of the catheter in all 37 patients. Definitive successful drainage, defined as hospital discharge without complementary surgery, was achieved in 32 patients (87%), without major complications. A temporizing effect was obtained in three additional patients (8%) who underwent curative surgery for the underlying process after complete drainage of the abscess. Two patients died from multiple organ failure before their abscess healed. Considerations for successful drainage of subphrenic abscesses include a good knowledge of the subphrenic space anatomy, the use of large-bore drainage catheters and the recognition and correct management of underlying enteric, biliary or pancreatic fistulas.
(Invited) Alignment Control of Carbon Nanotube Forests From Random to Nearly Perfectly Aligned by Utilizing Crowding Effect (2013)

Abstract not Available.
Die Evaluation von koronaren Herzbypässen mit einem 256-Zeilen MDCT: der Einfluss der Herzfrequenz, der Herzfrequenzvariabilität sowie der Lokalisation der z-Achse auf die Bildqualität (2014)

Das Ziel dieser prospektiven Studie war es, den Einfluss der Herzfrequenz (HF), der Herzfrequenzvariabilität (HFV) sowie der Lokalisation der z-Achse auf die Bildqualität bei Untersuchungen von koronaren Herzbypässen (CABG) mit einem 256-Zeilen-Multidetektor-Computertomographen (MDCT) zu untersuchen.
Direct Sensing of Thrust and Velocity for a Quadrotor Rotor Array (2017)

Trajectory tracking of micro UAVs requires accurate thrust and velocity estimates. High-quality motion control of quadrotors typically employs accurate high-speed optical sensing indoors. However, these measurements are not available outdoors, and GPS is unreliable and inadequate for performance motion control. We have developed small embedded force sensors that mount between a micro UAV's airframe and motors - forces generated by the rotors are measured as they are transmitted to the rigid body of the aircraft. The direct force measurements can be directly integrated with a model of the mapping between aircraft motion and induced rotor forces. From this, the translational velocities of the rotors relative to the local wind can be measured, and thus the overall velocity of the aircraft can be inferred. We have assembled a proof-of-concept quadrotor platform with all four rotors fitted with force sensors, and demonstrate accurate measurement of a quadrotor's lateral velocity during prescribed motions using the onboard force sensors. The vertical velocity measurement was found to be insensitive.
Figure S4 from Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) (2023)

&lt;p&gt;For xenograft experiments body weight (grams) are plotted over time (days) for different BVD-523 treatment groups in experiment using (A) A375 (n=15 for BVD-523 treatment groups, n= 10 for vehicle group), (B) Colo205 (n=12), (D) MIAPaCa2 (n=12), and (F) ZR-75.1 (n=15). Mean tumor volume {plus minus}SEM over time (days), is shown for (C) MIAPaCA2 and (E) ZR-75.1, following BVD-523 treatment.&lt;/p&gt;
Seeing is believing: Tissue clearing makes see-through rodents (2016)

A new tissue clearing technique can shrink and make entire animals transparent for full-body microscale imaging.
Depth-resolved collagen order after in vivo rabbit corneal cross-linking (2019)

Vancouver Convention Centre, Vancouver, B.C., April 28 – May 2 (2019). -- https://iovs.arvojournals.org/article.aspx?articleid=2740977
Acoustic edge effect: Novel acoustophoretic cell retention to enable continuous bioprocessing (2017)

There is currently a shift in Bioprocessing towards continuous manufacturing of monoclonal antibodies or recombinant proteins in perfusion mammalian cell cultures (Konstantinov &amp; Cooney, Journal of Pharmaceutical Sciences, 2015). A cell retention device is the key technology component that enables the shift to continuous production. A novel acoustic cell retention device operates by continuously drawing off a harvest flow, equal to the perfusion rate of the bioreactor, while recirculating the retained cells back to the bioreactor. The harvest flow path is tangent and significantly smaller than the recirculation rate. The device utilizes a novel acoustophoretic effect known as an “acoustic edge/interface” effect in conjunction with a recirculating flow beneath the acoustic harvest chamber which collects and returns cells to the bioreactor. This interface effect operates by creating a radiation pressure/force field at the interface between cell-free harvest and cell-laden circulating fluids. Numerical results show an insight into the mechanism of the acoustic edge effect. Experimental results confirm the existence of this novel acoustic edge effect. CHO cell perfusion cultures were operated continuously for &amp;gt;15 days. This technology delivers continuous cell retention and steady unhindered product transmission enabling continuous production of biopharmaceuticals unlike traditional hollow-fiber tangential flow filtration.
Ropivacaine Infusion in Diabetics Subject with Peripheral Arterial Disease. A Prospective Study (2012)

30-day peridural analgesia with ropivacaine is a valuable therapeutic option in severe peripheral limb ischemia subjects with contraindication to surgery and with pharmacological therapy failure.
Apparatus and method for measurement of the mechanical properties and electromigration of thin films (2023)

A method for characterizing a sample comprising the steps of depositing the sample on a substrate, measuring a first change in optical response of the sample, changing the lateral strain of the sample, measuring a second change in optical response of the sample, comparing the second change in optical response of with the first change in optical response and associating a difference between the second change and the first change in optical response with a property of interest in the sample. The measurement of the first change in optical response is made with the sample having an initial lateral strain. The measurement of the second change in optical response is made after the lateral strain in the sample is changed from the initial lateral strain to a different lateral strain. The second change in optical response is compared to the first change in optical response to find the difference between the second change and the first change.
ACS Chemical Neuroscience Molecule Spotlight on Sabril (2010)

Sabril (vigabatrin) oral solution was approved by the FDA on August 21st, 2009 for treatment of infantile spasms in children ages 1 month to 2 years and complex partial seizures in adults (tablets).
Vibrational analysis of selected nicotinic acid hydrazones in solid state (2016)

Aroylhydrazones exist in various tautomeric and isomeric forms, depending on their molecular structure and the presence of other species, such as solvent or a metal ion. Particularly interesting are those with a hydroxyl group in ortho position regarding the C=N double bond, which can be involved in tautomeric equilibria not only with the hydrazide part of the molecule, adopting a ketoamine form (form I, –CO–NH–N=CH–) or an enolimine form (form II, –COH=N–N=CH–), but also with the salicylaldehyde originating part of the molecule, yielding in a form with a carbonyl group on the cyclic moiety (form III, –CO–NH–NH–CH=CH–CO–). Five new aroylhydrazones derived from nicotinic acid were synthesized, all having an ortho hydroxyl group, but differing in the other substituent and its position on the aromatic ring (Fig. 1). Hence structural forms of derivatives with an additional hydroxyl group in position 3 (1) and 5 (2), chlorine atom in position 3 (3), a methoxy group in position 4 (4) and a nitro group in position 5 (5) on the phenyl ring were studied using vibrational spectroscopy. Infrared (IR) and Raman spectra of the solid substances were acquired and the normal modes assigned using DFT calculations at B3LYP/6-31+G(2d, 2p) level of theory, within both, harmonic and anharmonic approximations. The optimized geometries as well as IR and Raman spectra were obtained for four tautomeric (I–IV) and two isomeric (E and Z) forms for each of the synthesized compounds. The theoretical results indicated that the dominant structure of all the studied aroylhydrazones was the most stable E isomer in ketoamine form I. Moreover, characteristic IR and Raman bands were identified for all the investigated compounds.
An efficient variable step-size proportionate affine projection algorithm (2011)

Proportionate-type affine projection algorithms (PAPAs) are very attractive choices for echo cancellation. These algorithms combine the good features (convergence and tracking) of the affine projection algorithm (APA) and the proportionate idea, which exploits the sparseness character of the echo path in order to further increase their convergence rate. In this paper, we develop a variable step-size (VSS) version of a recently proposed PAPA. The new algorithm achieves a good compromise between fast convergence rate and low misadjustment, but also has a low computational complexity as compared to its classical counterparts.
Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study (2007)

In this open-label pilot study, SCIT with an HDM extract in patients with AD led to a significant improvement of AD mirrored by a reduction of SCORAD as well as serological and immunological changes, which might serve as valuable parameters to estimate the therapeutic effect of SCIT.
Sensitivity of porous silicon rugate filters for chemical vapor detection (2008)

The characteristics of chemical vapor sensors constructed from porous Si rugate filters are examined. The peak position of the resonant wavelength exhibits a redshift response upon exposure to ethanol vapors. The filter response scales with the vapor partial pressure; the concentration level is estimated based on theoretical calculations. The formation of two stacked rugate filters with similar index contrast but different periodicities is used to test the extent of liquid infiltration into each individual filter. The penetration length of the condensate is found to be comparable to the thickness of the filter; in a 11.3-μm-thick filter, a steady-state response is achieved in 4min.
Tandem Pd(II)-Catalyzed Vinyl Ether Exchange−Claisen Rearrangement as a Facile Approach to γ,δ-Unsaturated Aldehydes (2007)

A sequential allyl vinyl ether formation-Claisen rearrangement process catalyzed by a palladium(II)-phenanthroline complex is reported. The effects of allylic alcohol structure, type of vinylating agent, and palladium catalysts are discussed. This method provides a convenient approach to gamma,delta-unsaturated aldehydes under mild conditions that avoid the use of toxic Hg(II) catalysts. The new methodology has been successfully demonstrated on the kilogram scale.
Current Status of Partial Nephrectomy in the Management of Kidney Cancer (1999)

BACKGROUND: The technique of partial nephrectomy for managing renal cancers is well recognized, but guidelines regarding indications for its use are not generally accepted. METHODS: The authors review the indications for partial nephrectomy in various clinical situations, and they include their own experience to clarify the utility of the technique. RESULTS: Intraoperative renal ultrasound and helical computed tomography can assist the surgeon in technical decisions. Partial nephrectomy is considered when nephrectomy would render the patient anephric and dependent on dialysis. CONCLUSIONS: The technical and operative advances in partial nephrectomy make the approach increasingly attractive for patients with kidney cancer in a variety of clinical circumstances.
HSPA Radio Network Planning and Optimization (2009)

This chapter contains sections titled: Key Differences Between HSPA and Legacy Rel.'99 Channels Link Budget Analysis Overview of System Level Simulations Cell Planning Process Optimization with Drive Test Tools Main Radio Parameters Affecting HSPA Performance Dynamic Network Optimization (DNO) Tools Summary References
Factores asociados a insuficiencia renal postoperatoria en cirugía de revascularización miocárdica (2015)

Objetivos: Determinar qu antecedentes clnicos del paciente y factores del procedimiento quirrgico se asocian con la aparicin de insuficiencia renal postoperatoria en pacientes sometidos a ciruga de revascularizacin miocrdica. Mtodos: estudio llevado a cabo entre enero de 2005 y diciembre de 2013, de casos y controles anidado en una cohorte, en la que se incluyeron pacientes sometidos a ciruga de revascularizacin miocrdica electiva que presentaron insuficiencia renal postoperatoria durante el postoperatorio inmediato hasta el egreso. Los controles estuvieron conformados por pacientes sometidos a ciruga de revascularizacin miocrdica electiva que no desarrollaron insuficiencia renal postoperatoria inmediata hasta el egreso. Se realiz un modelo de regresin logstica para determinar los factores asociados a insuficiencia renal postoperatoria. Las asociaciones se expresaron en razones de disparidad con sus respectivos intervalos de confianza. Resultados: la edad avanzada [OR 1,03 IC95% (1,01-1,04)], la presencia preoperatoria de diabetes mellitus [OR 1,8 IC95% (1,9-3,4)], la insuficiencia cardiaca [OR 2,7 IC 95% (1,1-6,7)] y el mayor tiempo de perfusin [OR 1,02 IC 95% (1,01-1,03)] se asociaron con mayor riesgo de insuficiencia renal postoperatoria, en tanto que el mayor hematocrito [OR 0,86 IC95% (0,82-0,91)] y la mayor fraccin de eyeccin [OR 0,94 IC95% (0,92-0,96)] se relacionaron con disminucin del riesgo de insuficiencia renal postoperatoria.
Limitations of ATSSS technology in ATSC 3.0 – 5G convergent systems (2021)

This paper explores the use of the 3GPP technology Access Traffic Steering, Switching and Splitting (ATSSS) to enable IP layer convergence between 5G and ATSC 3.0. ATSSS was first introduced in Release 16 and originally devised to integrate non-3GPP access networks such as WiFi and wireline into the 5G System; and is flexible enough to include IP-based broadcast standards like ATSC 3.0. The limitations of the ATSSS technology to enable this convergence are detailed in this paper. A proposal to overcome them with a high-level converged architecture between ATSC 3.0 and 5G, featuring ATSSS Release 17 characteristics, is additionally described.
663. Genetic Re-Targeting of Adenovirus Using a Hyperstable scFv Domain and an Affibody® Molecule Against Her2/neu (2004)

Leif Lindholm,1 Karin Andersson,1 Pierre Boulanger,2 Karolin Frykholm,1 Petra Henning,1 Rob Hoeben,3 Saw See Hong,2 Jenny Johannisson,1 Maria Magnusson,1 Susanna Myhre,1 Per-Åke Nygren,4 Elisabeth Pettersson,1 Stefan Ståhl,4 Jort Vellinga,3 Maria Wikman.4
An in silico method to predict net calcium transfer during hemodialysis (2017)

International guidelines for chronic hemodialysis patients suggest a dialysate calcium concentration between 1.25 and 1.5 mmol/L. However, it is not certain if these dialysate calcium levels result in net calcium transfer into the patient. With ubiquitous prevalence of vascular calcification in hemodialysis patients, it is pertinent to model the mass balance of calcium during dialysis. To this end, we developed a two compartmental patient model and spatiotemporal representation of dialyzer model to investigate and quantify the calcium mass balance during dialysis. The model accounts for calcium-albumin binding and varying protein concentration; the latter accounts for the Gibbs-Donnan effect. The model simulations suggest that despite a lower dialysate calcium concentration of 1.25 mmol/L, some of our patients may be loaded with calcium during dialysis. This net calcium flux from dialysate to blood side may be a potential contributor to vascular calcification, a primary cause of cardiovascular mortality in hemodialysis patients.
Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy (2015)

Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibition plays an important role in neurological disorders. Gephyrin is a central player at inhibitory postsynapses, directly binds and organizes GABAA and glycine receptors (GABAARs and GlyRs), and is thereby indispensable for normal inhibitory neurotransmission. Additionally, gephyrin catalyzes the synthesis of the molybdenum cofactor (MoCo) in peripheral tissue. We identified a de novo missense mutation (G375D) in the gephyrin gene (GPHN) in a patient with epileptic encephalopathy resembling Dravet syndrome. Although stably expressed and correctly folded, gephyrin-G375D was non-synaptically localized in neurons and acted dominant-negatively on the clustering of wild-type gephyrin leading to a marked decrease in GABAAR surface expression and GABAergic signaling. We identified a decreased binding affinity between gephyrin-G375D and the receptors, suggesting that Gly375 is essential for gephyrin-receptor complex formation. Surprisingly, gephyrin-G375D was also unable to synthesize MoCo and activate MoCo-dependent enzymes. Thus, we describe a missense mutation that affects both functions of gephyrin and suggest that the identified defect at GABAergic synapses is the mechanism underlying the patient's severe phenotype.
Towards an Advanced Linear International Collider (2019)

This document provides detailed information on the status of Advanced and Novel Accelerators techniques and describes the steps that need to be envisaged for their implementation in future accelerators, in particular for high energy physics applications. It complements the overview prepared for the update of the European Strategy for particle physics, and provides a detailed description of the field. The scientific priorities of the community are described for each technique of acceleration able to achieve accelerating gradient in the GeV~range or above. ALEGRO working group leaders have coordinated the preparation of their working group contribution and contributed to editing the documents. The preparation of this document was coordinated by the Advanced LinEar collider study GROup, ALEGRO. The content was defined through discussions at the ALEGRO workshop in Oxford UK, March 2018, and an advanced draft was discussed during a one day meeting prior to the AAC workshop in Breckenridge, CO, USA, August 2018. This document was submitted as an addendum to the ALEGRO submission to the European Strategy for Particle Physics.
High Throughput Quantification of Protein Expression of Cancer Antigens in Tissue Microarray Using Quantum Dot Nanocrystals (2006)

We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.
Regulation of S-Nitrosylation in Aging and Senescence (2019)

Nitric oxide signals through several distinct mechanisms, including interaction with the heme group of guanylyl cyclase enzymes resulting in modulation of cGMP levels in the vascular endothelium. Alternatively, reactive nitrogen oxide species can bind cysteine residues in target proteins forming S-nitrosothiols. S-nitrosylation is recognized as an important post-translational modification of dozens of proteins, which plays a key role in cellular homeostasis, metabolism, and various disease states. By denitrosylating target proteins, S-nitrosoglutathione reductase (GSNOR/ADH5) plays a pivotal role in the regulation of protein S-nitrosylation. GSNOR expression is reduced in primary senescent cells that accumulate during aging in rodents and humans. Reduced GSNOR activity is accompanied by mitochondrial nitrosative stress, characterized by elevated S-nitrosylation of Drp1 and Parkin with the downstream effect of impaired mitophagy. The mechanism involves epigenetic downregulation of GSNOR by the ten-eleven translocation 1 protein. Conflicting recent reports show that GSNOR levels change with age in mice and humans. One report found that GSNOR levels decreased in peripheral blood mononuclear cell and brains of young to middle-aged mice. However, another report more convincingly showed that there was a significant increase in the hippocampal expression of GSNOR in both old humans and mice. Increased GSNOR in old mice resulted in loss of synaptic plasticity and reduced long-term potentiation memory, in part, by reducing calmodulin kinase IIa activation, which is known to increase the number of AMPA glutamate receptors near synapses. GSNOR levels may be a key biochemical hallmark of aging, but subject to the Goldilocks principle such that its levels need to be maintained in a narrow range according to context, making it a problematic therapeutic target in aging as opposing changes in expression or activity would be needed to stimulate mitophagy in senescence and synaptic plasticity in aging brains.
Hydroxyl-Radical Footprinting (2007)

INTRODUCTIONThe hydroxyl-radical footprinting methodology has wide applications to studying protein-DNA interactions, as well as structural perturbations (e.g., bending) that occur in DNA during protein binding. Hydroxyl radicals cleave DNA by abstracting a hydrogen atom from C4 of the sugar in the minor groove. Protein binding over the minor groove generally protects the sugar from cleavage. Because a hydroxyl radical molecule is small and thus is not subject to the same steric restrictions as other agents (such as DNase I), hydroxyl-radical footprinting can give detailed information on protein binding to the minor groove. In this protocol, the radical is generated by Fe(II) EDTA, which cleaves hydrogen peroxide into a hydroxyl radical and a hydroxide ion. The radical then cleaves the sugar in a diffusion limited reaction. Ascorbic acid is included to regenerate the active Fe(II).