gebhart/patrepeval huggingface dataset:
Beam-Shaping Technique for End-Pumping Yb-Doped Fiber Laser with Two Laser-Diode Arrays (2005)

We describe a beam-shaping technique for two air-cooled high-power laser-diode arrays for pumping an Yb-doped double-clad fiber laser. In this technique, two right-angle prisms are employed to reshape the pumping beam. As a result, the beams of two air-cooled high-power laser-diode arrays were effectively coupled to the Yb-doped double-clad fiber, and a single-mode output beam of 23.3 W in the 1,080-nm region was obtained.
Endovascular Stent Graft Repair of Abdominal and Thoracic Aortic Aneurysms (2003)

Stent graft therapy for aortic aneurysms is a valuable alternative to open aortic repair, especially in older sicker patients with large aneurysms. Continued device improvements coupled with an enhanced understanding of the important role of aortic pathology in determining therapeutic success will eventually permit ESGs to be a more durable treatment of aortic aneurysms.
P‐48: An Oxide‐Semiconductor (OS) FET‐based Low‐Power Level Shifter Combined with OS LSI Technology‐based Display‐Controller COG for a Low‐Power OS Display System (2017)

The reduction of the power consumption of an oxide‐semiconductor (OS) display through the use of a high‐voltage OS FET‐based low‐power level shifter together with a low‐voltage display‐controller chip‐on‐glass (COG) based on OS LSI technology is proposed. The level shifter achieves a 26% reduction in power consumption with a small area.
An efficient solver for Cache Miss Equations (2002)

Cache Miss Equations (CME) (S. Ghosh et al., 1997) is a method that accurately describes the cache behavior by means of polyhedra. Even though the computation cost of generating CME is a linear function of the number of references, solving them is a very time consuming task and thus trying to study a whole program may be infeasible. The paper presents effective techniques that exploit some properties of the particular polyhedra generated by CME. Such techniques reduce the complexity of the algorithm to solve CME, which results in a significant speedup when compared with traditional methods. In particular, the proposed approach does not require the computation of the vertices of each polyhedron, which has an exponential complexity.
ChemInform Abstract: Pyrophosphito‐Bridged Diplatinum Chemistry (1989)

Abstract Review: (with much attention to the photochemistry; more than 90 refs.
ChemInform Abstract: BAKTERICIDE WIRKUNG VON 6‐(5‐GLIEDRIGEN HETEROARYLACETAMIDO)‐PENICILLANSAEUREN (1972)

Abstract Zahlreiche Penicilline (I) werden hergestellt und ihre baktericide Wirkung untersucht und diskutiert.
Framework for the composition and interoperation of the home appliances based on heterogeneous middleware in residential networks (2002)

Residential networks enable one to control and to compose functions on different home appliances, but the diversity of home appliances brings various kinds of middleware into a house. If home appliances in the same house use different middleware, they cannot know one another existence needless to say using one another functions. To solve the problem of the Tower of Babel in residential networks, this paper proposes the generic framework for the interoperability of the heterogeneous middleware networks in a house. This paper describes the software components of the proposed framework and presents prototype implementation.
Determination of the neutrino mass from the beta decay of gaseous molecular tritium (1992)

We set an upper limit of 8 eV for the mass of the electron antineutrino from studying the beta decay of tritium. We use a gaseous molecular tritium source, a high resolution magnetic spectrometer and a low background counting system to minimize the systematic errors encountered in these measurements. Our calibration data with radioactive {sup 83m}Kr enables us to measure our system response function and a good deal of atomic physics data. In addition to our end point results we have made the first measurement of the tritium beta decay spectrum below 200 keV. We find an excess of very low energy electrons which arise from molecular processes of the {sup 3}He-T{sup +} ion.
Delaunay Tessellations and Voronoi Diagrams in Cgal (2016)

The Cgal library provides a rich variety of Voronoi diagrams and Delaunay triangulations. This variety covers several aspects: generators, dimensions and metrics, which we describe in Section 2. One aim of this paper is to present the main paradigms used in CGAL: Generic programming, separation between predicates/constructions and combinatorics, and exact geometric computation (not to be confused with exact arithmetic!). The first two paradigms translate into software design choices, described in Section 4, while the last covers both robustness and efficiency issues, respectively described in Sec- tion 6 and 7. Other important aspects of the Cgal library are the interface issues, be they for traversing a tessellation, or for interoperability with other libraries or languages, see Section 5. We present in Section 8 some tessellations at work in the context of surface reconstruction and mesh generation. Section 9 is devoted to some on-going and future work on periodic triangulations (triangulations in periodic spaces), and on high-quality mesh generation with optimized tessellations. Section 10 provides typical numbers in terms of efficiency and scalability for constructing tessellations, and lists the remaining weaknesses. We conclude by listing some of our directions for the future.
Modulating retro-reflectors for space, tracking, acquisition, and ranging using multiple quantum-well technology (2002)

This paper describes a novel concept for optical interrogation, communication, and navigation between spacecraft platforms. The technique uses a gimbaled laser source on a pursuer spacecraft and an array of solid-state, multiple quantum well modulating retroreflectors on a target spacecraft. The sensor system provides high-bandwidth optical communication, centimeter-level relative positioning, and better than arc-minute-level relative attitude of the target platform with minimal sacrifice in target size, weight, and power. To accomplish the relative navigation, each target retroreflector return is modulated with a unique code sequence, allowing for individual discrimination of the detected composite signal at the pursuer location. Experimental results using a dual-platform, multi-degree-of-freedom testbed provide verification and demonstration of the concept, highlighting its potential for applications such as inter-spacecraft rendezvous and capture, long-baseline space interferometry, and formation flying.
Board-to-board optical interconnects using a parabolic mirror for high angular misalignment tolerance (2003)

A free space optical board-to-board interconnect is presented, utilizing a parabolic mirror to achieve high angular tolerance. A relation between the input and output angle of the system is calculated and simulation results are given.
Interaction of fibrinogen with its platelet receptor: kinetics and effect of pH and temperature (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of fibrinogen with its platelet receptor: kinetics and effect of pH and temperatureGerard A. Marguerie and Edward F. PlowCite this: Biochemistry 1981, 20, 5, 1074–1080Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/bi00508a005https://doi.org/10.1021/bi00508a005research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vegetarians have higher plasma alpha-tocopherol relative to cholesterol than do nonvegetarians. (1992)

Biological antioxidants are thought to play a protective role in certain disease processes, including atherosclerosis. To compare the relative antioxidant/atherogenic risk between vegetarians (presumed lower risk) and omnivores (higher risk), the alpha-tocopherol, total cholesterol and fatty acid (FA) profiles were determined in the plasma of 79 vegetarians (28 males, 51 females) and 79 age- and sex-matched nonvegetarians. In the vegetarian group, mean (+/- SEM) plasma alpha-tocopherol was 714 +/- 46 micrograms/dl for males and 725 +/- 24 for females; corresponding cholesterol values were 122 +/- 5 mg/dl and 138 +/- 3, respectively, which were significantly lower than the respective control values (928 +/- 38; 883 +/- 23 and 206 +/- 6; 188 +/- 4). However, when plasma tocopherol was expressed in terms of cholesterol, the tocopherol: cholesterol molar ratio was significantly enhanced for both male (27%) and female (11%) vegetarians. Vegetarians also had a lower atherosclerosis risk based on their plasma FA profile (higher linoleic:oleic acid ratio) which correlated well (r = 0.72; p less than 0.001) with plasma alpha-tocopherol:cholesterol molar ratio. Since the bulk of tocopherol is transported in low-density lipoprotein, this lipoprotein in vegetarians may be better protected against lipid peroxidation, a process believed to be important in the pathogenesis of atherosclerosis.
Direct Identification and Quantitative Determination of Acidic and Neutral Diterpenes Using 13C-NMR Spectroscopy. Application to the Analysis of Oleoresin of Pinus nigra (2002)

International audience
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases (2022)

Our study identified a new mechanism linking Trp metabolism to intestinal inflammation and IBD. Bringing back XANA and KYNA has protective effects involving AhR and the rewiring of the energy metabolism in intestinal epithelial cells and CD4<sup>+</sup> T cells. This study paves the way for new therapeutic strategies aiming at pharmacologically correcting its alterations in IBD by manipulating the endogenous metabolic pathway with AADAT.
Effects of degree of polymerization, surface chemistry, and surface charge density on cellulose nanocrystal thermal stability (2019)

International audience
Dynamic NMR studies of ligand‐receptor interactions: Design and analysis of a rapidly exchanging complex of FKBP‐12/FK506 with a 24 kDa calcineurin fragment (1996)

Dynamic NMR methods, such as differential line broadening and transferred NOE spectroscopy, are normally reserved for the study of small molecule ligand interactions with large protein receptors. Using a combination of isotope labeling and isotope edited NMR, we have extended these techniques to characterize interactions of a much larger protein/drug complex, FKBP-12/ FK506 with its receptor protein, calcineurin. In order to examine this multicomponent system by dynamic NMR methods, the 93 kDa, tightly bound FKBP-12/FK506/Cn complex was replaced with a lower affinity, rapidly exchanging system consisting of FKBP-12/FK506 (13 kDa), recombinant calcineurin subunit B (CnB) (20 kDa), and a synthetic peptide (4 kDa) corresponding to the B binding domain (BBD) of calcineurin catalytic subunit A (CnA). Analysis of 1H-13C HSQC data acquired for the FKBP-12/ 13C-FK506 and FKBP-12/13C-FK506/CnB/BBD complexes indicates that FKBP-12/FK506 and CnB/BBD are in fast exchange in the quaternary complex. Comparison of proton line widths shows significant broadening of resonances along the macrocycle backbone at 13-CH, 13-OMe, 15-OMe, 18-CH2, 20-CH, 21-CH, and 25-Me, as well as moderate broadening on the macrocycle backbone at 17-Me, 24-CH, and the pyranose 12-CH2 protons. The tri-substituted olefin and cyclohexyl groups also show moderate broadening at the 27-Me, 28-CH, and 30-CH2 positions, respectively. Unexpectedly, little line broadening was observed for the allyl resonances of FK506 in the quaternary complex, although 13C longitudinal relaxation measurements suggest this group also makes contacts with calcineurin. In addition, intermolecular transfer NOE peaks were observed for the allyl 37-CH2, 21-CH, 30-CH2, 13-OMe, 15-OMe, 17-Me, 25-Me, and 27-Me groups, indicating that these are potential sites on the FK506 molecule that interact with calcineurin.
Steady-State Analysis of HVAC Performance using Indoor Fans in Control Design (2019)

Indoor fans are high-authority actuators in heating, ventilation, and air conditioning (HVAC) systems since they facilitate the transfer of heat between refrigerant and room air. In some variable refrigerant flow (VRF) systems, the indoor fan speeds are under the control of the occupants, rather than the HVAC control system. This paper studies the benefits of transferring control of the indoor fans to the HVAC controller. We quantify the system performance using five metrics related to occupant comfort and power consumption. The first metric measures the ability of the HVAC system to accommodate users with different temperature preferences by quantifying the largest difference in requested room temperatures that can be achieved with and without the aid of indoor fans. The second and third metrics measure the ability of the HVAC system to reject extreme heating and cooling loads. The final two metrics measure the reduction in power consumption obtained by manipulating the indoor fan speeds. Each of these metrics is computed via linear programming for varying numbers of indoor units. Simulation results indicate that the maximum steady-state difference in room temperatures is tripled, and the maximum rejected heating and cooling loads are doubled. Furthermore, power consumption is significantly reduced.
High-performance liquid chromatography of corynomycolic acids as a tool in identification of Corynebacterium species and related organisms (1992)

A high-performance liquid chromatography (HPLC) study of 307 strains of Corynebacterium species and related taxa revealed that strains classified as "Corynebacterium aquaticum"; "Corynebacterium asperum"; and Centers for Disease Control (CDC) groups 1, 2, A-3, A-4, A-5, B-1, B-3, E, F-2, and I-2 as well as some unidentified coryneforms do not contain any corynomycolic acids; therefore, they should not be included in the genus Corynebacterium. Such an HPLC method of identification permitted the correct assignment to the genus Rhodococcus of two unpigmented strains of coryneform bacteria whose mycolic acid profiles were comparable to those of Rhodococcus equi. Bacteria belonging to CDC groups ANF-1, ANF-3, F-1, G-1, G-2, and I-1, as well as some other Corynebacterium sp. strains, yielded corynomycolic acid HPLC patterns related to those of Corynebacterium species. Either similarities or differences were observed in the corynomycolic acid profiles of Corynebacterium species tested after culture on sheep blood agar and/or sheep blood agar supplemented with Tween 80, which demonstrated that identification at the species or group level is possible. However, Corynebacterium striatum and CDC group I-1 bacteria as well as CDC group G-1 and group G-2 bacteria had indistinguishable HPLC patterns. Conversely, some variations were observed within some species as Corynebacterium xerosis, C. striatum, and Corynebacterium minutissimum. The evaluation procedure of this HPLC method by mass spectrometry analysis of isolated eluted peaks revealed that analytical reverse-phase HPLC alone does not provide any structural information, since isomers with identical polarities coeluted as a single peak. Nevertheless, HPLC is a rapid and reliable method for identification of corynomycolic acid-containing bacteria in the clinical microbiological laboratory.
Data from Insulin Increases <i>De Novo</i> Steroidogenesis in Prostate Cancer Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissues. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer; however, regression initially seen with ADT gives way to development of incurable castration-resistant prostate cancer (CRPC). Although ADT generates a therapeutic response, it is also associated with a pattern of metabolic alterations consistent with metabolic syndrome including elevated circulating insulin. Because CRPC cells are capable of synthesizing androgens &lt;i&gt;de novo&lt;/i&gt;, we hypothesized that insulin may also influence steroidogenesis in CRPC. In this study, we examined this hypothesis by evaluating the effect of insulin on steroid synthesis in prostate cancer cell lines. Treatment with 10 nmol/L insulin increased mRNA and protein expression of steroidogenesis enzymes and upregulated the insulin receptor substrate insulin receptor substrate 2 (IRS-2). Similarly, insulin treatment upregulated intracellular testosterone levels and secreted androgens, with the concentrations of steroids observed similar to the levels reported in prostate cancer patients. With similar potency to dihydrotestosterone, insulin treatment resulted in increased mRNA expression of prostate-specific antigen. CRPC progression also correlated with increased expression of IRS-2 and insulin receptor &lt;i&gt;in vivo&lt;/i&gt;. Taken together, our findings support the hypothesis that the elevated insulin levels associated with therapeutic castration may exacerbate progression of prostate cancer to incurable CRPC in part by enhancing steroidogenesis. &lt;i&gt;Cancer Res; 71(17); 5754–64. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Quantum Speedup for the Minimum Steiner Tree Problem (2019)

A recent breakthrough by Ambainis, Balodis, Iraids, Kokainis, Prūsis and Vihrovs (SODA'19) showed how to construct faster quantum algorithms for the Traveling Salesman Problem and a few other NP-hard problems by combining in a novel way quantum search with classical dynamic programming. In this paper, we show how to apply this approach to the minimum Steiner tree problem, a well-known NP-hard problem, and construct the first quantum algorithm that solves this problem faster than the best known classical algorithms. More precisely, the complexity of our quantum algorithm is $\mathcal{O}(1.812^k\poly(n))$, where $n$ denotes the number of vertices in the graph and $k$ denotes the number of terminals. In comparison, the best known classical algorithm has complexity $\mathcal{O}(2^k\poly(n))$.
ChemInform Abstract: Enantioselective C—C Bond Activation of Allenyl Cyclobutanes: Access to Cyclohexenones with Quaternary Stereogenic Centers. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancing Absorption Bandwidth through Vertically Oriented Metamaterials (2019)

Metamaterials research has developed perfect absorbers from microwave to optical frequencies, mainly featuring planar metamaterials, also referred to as metasurfaces. In this study, we investigated vertically oriented metamaterials, which make use of the entire three-dimensional space, as a new avenue to widen the spectral absorption band in the infrared regime between 20 and 40 THz. Vertically oriented metamaterials, such as those simulated in this work, can be experimentally realized through membrane projection lithography, which allows a single unit cell to be decorated with multiple resonators by exploiting the vertical dimension. In particular, we analyzed the cases of a unit cell containing a single vertical split-ring resonator (VSRR), a single planar split-ring resonator (PSRR), and both a VSRR and PSRR to explore intra-cell coupling between resonators. We show that the additional degrees of freedom enabled by placing multiple resonators in a unit cell lead to novel ways of achieving omnidirectional super absorption. Our results provide an innovative approach for controlling and designing engineered nanostructures.
Predictive Planning for Heterogeneous Human-Robot Teams (2010)

This research was supported in part by AFOSR (FA9550-08-1-0086) and MURI (FA9550-08-1-0356).
Coupling Nonlinear Sensors for Enhanced Sensitivity: A Prototype Using the 3 Coupled-Core Fluxgate Magnetometer (2006)

Recently, we have shown the emergence of oscillations in overdamped undriven nonlinear dynamic systems subject to carefully crafted coupling schemes and operating conditions [In, 2003], [Bulsara, 2004]. Here, we present results obtained from a system of N /spl equiv/ 3 coupled-core fluxgate magnetometer system; the oscillatory behavior is triggered when the coupling constant exceeds a threshold value (bifurcation point), and the oscillation frequency exhibits a characteristic scaling behavior with the "separation" of the coupling constant from its threshold value, as well as with an external target dc magnetic flux signal. The oscillations, which can be induced at frequencies ranging from a few Hz to high-kHz, afford a novel new detection scheme for target signals; in addition, the coupled-core system offers the possibility of significantly enhanced responsivity over its single fluxgate counterpart.
Nitro-heteroaromatic derivatives of amino-acids and peptides. Part IV. A circular dichroic method for the selective determination of cysteinyl residues (1972)

Cysteinyl residues react with 2-fluoro-3-nitropyridine rapidly and under mild conditions. The c.d. spectra of the resulting chromophoric S-3-nitro-2-pyridyl derivatives have been recorded. The results suggest the application of the reaction to the analytical determination of thiol groups in peptide molecules.
Cu‐Catalyzed Diastereo‐ and Enantioselective Reactions of γ,γ‐Disubstituted Allyldiboron Compounds with Ketones (2020)

A catalytic diastereo- and enantioselective method for the preparation of complex tertiary homoallylic alcohols containing a vicinal quaternary carbon stereogenic center and a versatile alkenylboronic ester is disclosed. Transformations are promoted by 5 mol % of a readily available copper catalyst bearing a bulky monodentate phosphoramidite ligand, which is essential for attaining both high dr and er. Reactions proceed with a wide variety of ketones and allylic 1,1-diboronate reagents, which enables the efficient preparation of diverse array of molecular scaffolds.