gebhart/patrepeval huggingface dataset:
Extended frequency analysis of magnetic losses under rotating induction in soft magnetic composites (2012)

We present novel results on magnetic losses in soft magnetic composites (SMCs) excited with rotating field. Soft composites are very promising in electrical engineering applications, where new topologies of electrical machines with two- and three-dimensional induction loci are increasingly found. An experimental characterization of industrial SMC products has, therefore, been carried out, up to the kilohertz range, under alternating and circular flux loci, making use of a specifically designed and optimized loss measuring setup. The obtained results have been analyzed for all kinds of excitation, according to the loss separation concept, with the emphasis being placed on the relationship between the rotational and the alternating loss components. In particular, it is found that the ratio between the rotational and the alternating losses is, for any given peak induction, independent of frequency.
Antimicrobial susceptibility testing of Serpulina hyodysenteriae (1994)

The macrobroth dilution technique was used to test the in-vitro effectiveness of 4 commonly used antimicrobial agents against 23 Australian isolates and 7 overseas strains of Serpulina hyodysenteriae. Minimum inhibitory concentrations and minimum bactericidal concentrations were determined. The growth of 90% of isolates was inhibited by dimetridazole at a concentration of 4 micrograms/mL, and by tiamulin at 8 micrograms/mL. Australian isolates resistant to both antimicrobial agents were identified. Lincomycin was less effective than these antimicrobial agents, with 90% of isolates requiring a concentration of 128 micrograms/mL for inhibition of growth, and 54% being susceptible at 64 micrograms/mL. Tylosin did not prevent the growth of the majority of S hyodysenteriae isolates tested, and 90% were resistant to concentrations of > or = 128 micrograms/mL. Resistant isolates came from different geographical areas. Resistance was not related to overall genetic background of the spirochaetes, and was not correlated with the presence of plasmids or the serogroup of the isolates.
Randomized placebo-controlled trial of intravenous vitamin C plus docetaxel in metastatic prostate cancer. (2023)

e17050 Background: Some phase I/II trials showed that combining high dose IV vitamin C with chemotherapies decreased toxicities and improved QoL in advanced cancers, while others failed to show benefits. While grade ¾ AEs are not typically a co-primary endpoint, they are a measure of cumulative toxicity. We investigated whether high-dose IV vitamin C could improve prostate-specific antigen (PSA) response rate and mitigate docetaxel toxicities in patients with metastatic castrate-resistant prostate cancer (mCRPC) receiving docetaxel. Methods: Patients were randomized (2:1) to receive docetaxel (75mg/m2 IV every 3 weeks) plus IV vitamin C (1g/kg) or placebo twice a week. The primary endpoints were PSA50 response by24 weeks and adverse events (AEs) of fatigue, nausea, bone pain, and anorexia. Secondary endpoints included overall survival (OS) and QoL measured by the Functional Assessment of Cancer Therapy-Prostate (FACT-P). Results: 50 patients were randomized, 47 received therapy (treatment N = 32, control N = 15), 3 untreated (withdrawal, elevated creatine, low hemoglobin). The median age was 74 years (range 45-85) and ECOG 1. The median PSA was 108.3 ng/mL (range: 0.3, 2102.3). The median number of chemotherapy cycles was 6 (IQR 3-8). The study was suspended after the pre-specified interim analysis for primary endpoints showed futility. The PSA50 response was 41% for treatment and 33% for control (P = 0.44). Grade 1-2 and grade 3-4 prespecified AEs occurred in 69% and 6% of treatment group patients versus 60% and 0% of control group patients (one-sided Cochran Armitage test, P =0.90). Diarrhea (72% vs 19%) and anemia (47% vs 25%) and neutropenia (22% vs 19%) are more frequent in the Vit C group. Compared with the control group, treatment group patients showed a trend towards shorter median OS. FACT-P was not significantly different at any timepoints. Conclusions: Initial concurrent high-dose IV vitamin C with docetaxel did not improve PSA response, toxicity, or clinical outcomes. MCRPC patients receiving docetaxel should be advised against seeking concurrent high-dose IV vitamin C. Clinical trial information: NCT02516670 .
A novel curvature-based shape Fourier Descriptor (2008)

Shape descriptors have demonstrated encouraging potential in retrieving images based on image content. A number of shape descriptors have been reported in the literature. Nevertheless, most of the reported descriptors still face accuracy and computational challenges. Fourier descriptors are considered to be promising descriptors as they are based on sound theoretical foundation, and possess computational efficiency and attractive invariance properties. In this paper, we propose a novel Fourier descriptor based on contour curvature. The proposed descriptor takes an unconventional view of the curvature-scale-space representation of a shape contour as it treats it as a 2-D binary image (hence referred to as Curvature-Scale Image, or CSI). The invariant descriptor is derived from the 2-D Fourier transform of the Curvature-Scale Image. This allows the descriptor to capture detailed dynamics of the shape curvature and enhance the efficiency of the shape matching process. Experiments using images from the MPEG-7 database have been conducted to compare the performance of the proposed descriptor with the Curvature- Scale-Space Descriptor (CSSD), the Generic Fourier Descriptor (GFD), and the 1-D Fourier Descriptor (1-FD). The proposed descriptor demonstrated superior performance.
Geo-Supervised Visual Depth Prediction (2018)

We propose using global orientation from inertial measurements, and the bias it induces on the shape of objects populating the scene, to inform visual 3D reconstruction. We test the effect of using the resulting prior in depth prediction from a single image, where the normal vectors to surfaces of objects of certain classes tend to align with gravity or be orthogonal to it. Adding such a prior to baseline methods for monocular depth prediction yields improvements beyond the state-of-the-art and illustrates the power of gravity as a supervisory signal.
High-Performance Reference Governors for Faster Constraint Management (2022)

This paper proposes an extension of the reference governor, which we refer to as the High-Performance Reference Governor (HP-RG), for constraint management of linear systems. This extension is motivated by the fact that reference governors typically respond slower than model-predictive controllers, for example in response to a step change in the tracking setpoint. The newly-developed scheme introduces two modes: the “standard mode”, and the “fast mode”. In the standard mode, the scheme behaves the same as a standard reference governor. In the fast mode, however, the computed control command is less conservative than what a standard reference governor would compute. This control command is computed such that a constraint-admissible transition back to the standard mode is possible in the next timestep. This guarantees recursive feasibility and constraint satisfaction. To guarantee stability and prevent unnecessary mode switches, a stability-inducing mechanism is introduced, which allows transition to fast mode only when large variations in the setpoint are detected. To further reduce the computational footprint of HP-RG, an extension is presented that can be implemented using an explicit algorithm. Finally, the effectiveness of the developed algorithms is verified using numerical examples.
Supplementary Figure 2 from Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients (2023)

Supplementary Figure 2 from Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients
Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor (2022)

Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α<sub>2A</sub>-adrenergic receptor (α<sub>2A</sub>AR), seeking new α<sub>2A</sub>AR agonists chemotypes that lack the sedation conferred by known α<sub>2A</sub>AR drugs, such as dexmedetomidine. We identified 17 ligands with potencies as low as 12 nanomolar, many with partial agonism and preferential G<sub>i</sub> and G<sub>o</sub> signaling. Experimental structures of α<sub>2A</sub>AR complexed with two of these agonists confirmed the docking predictions and templated further optimization. Several compounds, including the initial docking hit '9087 [mean effective concentration (EC<sub>50</sub>) of 52 nanomolar] and two analogs, '7075 and PS75 (EC<sub>50</sub> 4.1 and 4.8 nanomolar), exerted on-target analgesic activity in multiple in vivo pain models without sedation. These newly discovered agonists are interesting as therapeutic leads that lack the liabilities of opioids and the sedation of dexmedetomidine.
Signaling mechanism of thrombin‐induced gingival fibroblast‐populated collagen gel contraction (2005)

1.--Thrombin is activated during gingival tissue injury and inflammation. Thrombin (platelet)-rich plasma has been used for periodontal regeneration with success. Thrombin and other bacterial proteases also affect the functions of adjacent periodontal cells via stimulation of protease-activated receptors (PARs). 2.--We noted that thrombin (0.1-2 U ml(-1)), human, and frog PAR-1 agonist peptide (20-240 microM) induced the gingival fibroblast (GF)-populated collagen gel contraction within 2 h of exposure. However, PAR-2, PAR-3, and PAR-4 agonist peptide (20-240 microM) showed little effect on collagen gel contraction. U73122 (phospholipase C inhibitor) and 2-APB (IP3 antagonist) were effective in inhibition of GF contraction. 3.--Thrombin-induced GF contraction was inhibited by 5 mM EGTA (an extracellular calcium chelator) and verapamil (an L-type calcium channel blocker). In addition, W7 (10 and 25 microM, a calcium/calmodulin (CaM) inhibitor), ML-7 (50 microM, myosin light chain kinase (MLCK) inhibitor), and HA1077 (100 microM, Rho kinase inhibitor) completely inhibited the thrombin-induced collagen gel contraction. Thrombin also induced the phosphorylation of ERK1/ERK2 and elevated the Rho-GTP levels in GF. 4.--However, U0126 only partially inhibited the thrombin-induced GF contraction. Similarly, wortmannin (100 nM), LY294002 (20 microM) (two PI3K inhibitor) and genistein also showed partial inhibition. Moreover, NAC was not able to suppress the GF contraction, as supported by the slight decrease in reactive oxygen species production in GF by thrombin. 5.--Thrombin also stimulated metalloproteinase-2 (MMP-2) and MMP-3 production in GF. But addition of GM6001 or 1,10-phenanthroline, two MMP inhibitors, could not inhibit the thrombin-induced GF contraction. 6.--These results indicate that thrombin is crucial in the periodontal inflammation and wound healing by promoting GF contraction. This event is mainly mediated via PAR-1 activation, PLC activation, extracellular calcium influx via L-type calcium channel, and the calcium/CaM-MLCK and Rho kinase activation pathway.
A Brassica napus gene family which shows sequence similarity to ascorbate oxidase is expressed in developing pollen. Molecular characterization and analysis of promoter activity in transgenic tobacco plants (1992)

The genomic clone named Bp10 contains a member of a small pollen-specific gene family of B. napus. The expression of the Bp10 gene family is maximal in early binucleate microspores and declines considerably in mature trinucleate pollen. Homologues of the Bp10 genes are expressed in the pollen of other plant species. The pollen-specific expression of the gene contained in the genomic clone was confirmed in tobacco plants transformed with a chimeric Bp10 promoter/GUS construct. A promoter fragment of 396 bp is sufficient to direct a strong and correct spatial and temporal expression in transgenic plants. The Bp10 gene family codes for proteins of 62 kDa showing approximately 30% sequence identify to cucumber and pumpkin ascorbate oxidases (AAOs). However, the AAO active centres are not conserved in the Bp10 products, suggesting an evolutionary relationship but a different enzymatic activity for these proteins. Expression of a recombinant Bp10 protein in E. coli inhibits bacterial growth on minimal medium, suggesting the production of an enzymatically active polypeptide in bacteria. No AAO activity could be correlated with the expression of the recombinant protein. Moreover, substances affecting AAO activity do not appear to influence the inhibitory activity of the protein produced in bacteria. However, as indicated by the rescue of bacterial growth in the presence of sodium bicarbonate or gaseous CO2, the Bp10 protein activity could be modulated by CO2 levels.
Thermodynamic approach to prediction of the stability of proposed radwaste glasses (1983)

Assessment of the geologic performance of radwaste glasses requires extrapolation of finite tests to very long times. A thermodynamic approach developed by Paul has been applied to leaching of both natural and synthetic glasses. This approach suggests that Savannah River waste glass should be as stable toward aqueous atttack as natural basalt. 11 references, 1 figure, 2 tables.
<title>Fieldable, real-time enzyme immunoassay kits for drugs on surfaces</title> (1994)

Immunoassays (e.g., RIA, EIA) have been demonstrated to be useful for rapid, convenient detection and semiquantitative analysis of drugs. Thermedics Detection, Inc. manufactures a rapid, sensitive, self-contained, disposable, EIA device, developed by Bio-Metric Systems, Inc., designed to allow untrained personnel to perform in field situations. This format has been developed for drugs in biological fluids and on surfaces. The analyte in the test sample competes with an enzyme-analyte conjugate for a limited number of immobilized antibody sites. The AccuPRESS Test format can detect analytes at 10 ppb in biological fluids, water, and soil, and on surfaces, such as suitcases, vehicles, tables and hands, with positive results indicated by clearly visible color development within 5 minutes. This format is designed to have all dry components and to have an ambient shelf life of greater than one year. The format is available for cocaine and opiate derivatives, including heroin, and is readily adaptable for use with numerous other drugs, explosives, and environmental pollutants.
Pharmacodynamic monitoring of immunosuppressive drugs (1998)

Pharmacodynamic (PD) monitoring measures the biological response to a drug, which alone--or coupled with pharmacokinetics--provides a novel method for optimization of drug dosing. PD monitoring has been investigated by us and other investigators primarily for four immunosuppressive drugs: cyclosporine (CsA), azathioprine (AZA), mycophenolate mofetil (MMF), and rapamycin (RAPA). PD monitoring of CsA and MMF involves measuring the activity of the enzymes calcineurin and inosine monophosphate dehydrogenase, respectively. The PD of AZA is assessed by measuring the activity of thiopurine methyltransferase, which is induced by a metabolite of AZA, 6-mercaptopurine. The PD for RAPA involves measuring the activity of a P70 S6 kinase in lymphocytes. To date, the most detailed studies have been performed with PD monitoring of CsA and MMF. Similarities exist in the PD responses to CsA and MMF in renal-transplant patients. At trough concentrations in blood, both drugs reduce the activity of their target enzymes by only 50%; however, considerable interpatient variability is evident. Throughout the dosing interval, the enzyme activities parallel the respective drug concentrations. AZA treatment of renal-transplant patients who exhibited an increase in thiopurine methyltransferase activity from time of transplantation resulted in fewer episodes of active rejection. Additional clinical trials are currently underway to relate various pharmacokinetics and PD parameters to clinical response, to ascertain which provides the best guide for dosing. PD monitoring may provide an alternative approach to additional measurements of drug concentrations.
Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia (2018)

Tumor cells accumulate spontaneous and drug-induced DNA damage, but they survive because of enhanced/altered DNA repair activities [1]. The hypothesis that cancer cells are addicted to particular D...
Converging Perturbed Microvasculature and Microglial Clusters Characterize Alzheimer Disease Brain (2010)

We have investigated physical properties of microvasculature and vessel association with microglial clusters in cortical tissue from Alzheimer disease individuals, classified as severe (ADsev) or mild (ADmild), and nondemented controls (ND). Immunostaining with laminin or von Willerbrand factor demonstrated numbers of microvessels and microvascular density were significantly higher in ADsev cases compared with levels in ADmild or ND cases suggesting proangiogenic activity in ADsev brain. Evidence for extravascular laminin immunoreactivity was found in ADsev tissue and was largely absent in ADmild and ND cases suggesting vascular remodeling in ADsev brain included abnormalities in blood vessels. Microgliosis was progressively increased from ND to ADmild to ADsev with the latter demonstrating areas of clustered microglia (groupings of three or more cells) rarely observed in ADmild or ND cases. Microglial clusters in ADsev brain were in close proximity with extravascular laminin and also plasma protein, fibrinogen, implicating vascular perturbation as a component of inflammatory reactivity. ADsev brain also exhibited elevated levels of the pro-inflammatory/angiogenic factors tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in association, relative to non-association, with microglial clusters. The presence of extravascular laminin and fibrinogen and the vascular modifying factors, TNF-α and VEGF in localization with clusters of activated microglia, is consistent with microglial-induced vascular remodeling in ADsev brain. Microglial-vascular reciprocal interactions could serve a critical role in the amplification and perpetuation of inflammatory reactivity in AD brain.
Salivary gland neoplasia in the dog and cat: survival times and prognostic factors (2001)

Twenty-four dogs and 30 cats with histopathologically confirmed salivary gland neoplasia were retrospectively reviewed in a multi-institutional study. The predominant presenting complaint for animals with salivary gland neoplasia was that of a mass being noted by the owner; other common complaints included halitosis, dysphagia, and exophthalmia. Siamese cats were overrepresented, indicating a possible breed predisposition. The most common histopathological type was simple adenocarcinoma. Cats had more advanced disease at diagnosis than did dogs, and clinical staging was prognostic in dogs. The median survival times for dogs and cats were 550 days and 516 days, respectively.
Rigid, Helical Arm Stars through Living Nickel Polymerization of Carbodiimides (2017)

Using the core-first growth strategy, we have synthesized a tris-Ni(II) initiator which bears three initiating sites for the ensuing polymerization of N-1-phenethyl-N′-methylcarbodiimide. The arms of these star polymers bearing chiral side chains adopt single-handed helical rod-like conformations. The polymerization occurs in a controlled, living fashion, and this multiarm architecture imparts a new set of intriguing properties including their self-assembly into diverse nanostructures when cast from different solvents. These assemblies, characterized by AFM, TEM, and DLS, include the formation of nanofiber networks and twisted superhelical nanostructures. Interestingly, by processing these polymers via electrospraying method, hollow and uniform platelet-like particles were obtained. These solvent-dependent morphologies of microparticles were observed by using SEM. The kinetic studies of polymerizations, inspection of self-aggregation behaviors, and electrosprayed architectures will open up possibilities for a variety of potential biomedical applications.
Electrowetting lenses for compensating phase and curvature distortion in arrayed laser systems (2013)

We have demonstrated a one-dimensional array of individually addressable electrowetting tunable liquid lenses that compensate for more than one wave of phase distortion across a wavefront. We report a scheme for piston control using tunable liquid lens arrays in volume-bound cavities that alter the optical path length without affecting the wavefront curvature. Liquid lens arrays with separately tunable focus or phase control hold promise for laser communication systems and adaptive optics.
Noise and bias in optical coherence tomography intensity signal decorrelation (2020)

Functional optical coherence tomography (OCT) imaging based on the decorrelation of the intensity signal has been used extensively in angiography and is finding use in flowmetry and therapy monitoring. In this work, we present a rigorous analysis of the autocorrelation function, introduce the concepts of contrast bias, statistical bias and variability, and identify the optimal definition of the second-order autocorrelation function (ACF) <i>g</i> <sup>(2)</sup> to improve its estimation from limited data. We benchmark different averaging strategies in reducing statistical bias and variability. We also developed an analytical correction for the noise contributions to the decorrelation of the ACF in OCT that extends the signal-to-noise ratio range in which ACF analysis can be used. We demonstrate the use of all the tools developed in the experimental determination of the lateral speckle size depth dependence in a rotational endoscopic probe with low NA, and we show the ability to more accurately determine the rotational speed of an endoscopic probe to implement NURD detection. We finally present <i>g</i> <sup>(2)</sup>-based angiography of the finger nailbed, demonstrating the improved results from noise correction and the optimal bias mitigation strategies.
Functional verification of the IBM System z10 processor chipset (2009)

This paper describes the comprehensive verification effort of the IBM System z10™ processor chipset, which consists of the z10™ quad-core central processor chip and the companion z10 symmetric multiprocessor (SMP) chip. The z10 processor chipset represented a significant redesign of its predecessor and thus presented a new challenge to ensure complete functional correctness of the product before the construction of actual system hardware. The z10 microprocessor pipeline was completely redesigned to support a doubling of the operating frequency. It also includes new hardware performance features, such as enhanced branch prediction, a reoptimized cache hierarchy, hardware-based prefetching, and a hardware implementation of decimal floating-point arithmetic in IEEE formats. In addition, there were significant hardware changes in the SMP storage hierarchy for optimized data latency performance. These changes include a new system topology, interprocessor book protocol, larger SMP size, and various aggressive cache ownership schemes. Key verification innovations are described, and a direct relationship to improved z10 system quality is provided for most cases.
Permutation Alignment Of Frequency-Domain Ica By Maximization Of Intra-Source Envelope Correlations (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012