gebhart/patrepeval huggingface dataset:
Data from A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;Non–small cell lung cancers (NSCLC) with activating EGFR mutations become resistant to tyrosine kinase inhibitors (TKI), often through second-site mutations in EGFR (T790M) and/or activation of the cMet pathway. We engineered a bispecific EGFR-cMet antibody (JNJ-61186372) with multiple mechanisms of action to inhibit primary/secondary EGFR mutations and the cMet pathway. JNJ-61186372 blocked ligand-induced phosphorylation of EGFR and cMet and inhibited phospho-ERK and phospho-AKT more potently than the combination of single receptor–binding antibodies. In NSCLC tumor models driven by EGFR and/or cMet, JNJ-61186372 treatment resulted in tumor regression through inhibition of signaling/receptor downmodulation and Fc-driven effector interactions. Complete and durable regression of human lung xenograft tumors was observed with the combination of JNJ-61186372 and a third-generation EGFR TKI. Interestingly, treatment of cynomolgus monkeys with JNJ-61186372 resulted in no major toxicities, including absence of skin rash observed with other EGFR-directed agents. These results highlight the differentiated potential of JNJ-61186372 to inhibit the spectrum of mutations driving EGFR TKI resistance in NSCLC. &lt;i&gt;Cancer Res; 76(13); 3942–53. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Directional Antennas for Angular Diversity in Wireless Sensor Networks (2005)

In this paper, multiple directional antennas are implemented on sensor network motes to create angular diversity in wireless sensor networks. Wireless sensor systems deploying directional antennas can establish angular diversity to cope with uncertainties in wireless channels. These systems also have improved bandwidth utilization and energy conservation. From our experiments, the degradations of the link quality under the fading channel are observed, and the proposed angular diversity increases the mean received signal strength, reduces the variance of the received power, and decreases the threshold-level crossing rate. Therefore, with a simple switching network and multiple directional antennas, the infrastructure of the wireless sensor network is enhanced.
A noninvasive method for the determination ofin vivomitral valve leaflet strains (2018)

Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and surgical planning applications for treatment of MV disease. Yet, to date, there are no accepted noninvasive methods for determination of MV leaflet deformation, which is a critical metric of MV function. In this study, we present a novel, completely noninvasive computational method to estimate MV leaflet in-plane strains from clinical-quality real-time three-dimensional echocardiography (rt-3DE) images. The images were first segmented to produce meshed medial-surface leaflet geometries of the open and closed states. To establish material point correspondence between the two states, an image-based morphing pipeline was implemented within a finite element (FE) modeling framework in which MV closure was simulated by pressurizing the open-state geometry, and local corrective loads were applied to enforce the actual MV closed shape. This resulted in a complete map of local systolic leaflet membrane strains, obtained from the final FE mesh configuration. To validate the method, we utilized an extant in vitro database of fiducially labeled MVs, imaged in conditions mimicking both the healthy and diseased states. Our method estimated local anisotropic in vivo strains with less than 10% error and proved to be robust to changes in boundary conditions similar to those observed in ischemic MV disease. Next, we applied our methodology to ovine MVs imaged in vivo with rt-3DE and compared our results to previously published findings of in vivo MV strains in the same type of animal as measured using surgically sutured fiducial marker arrays. In regions encompassed by fiducial markers, we found no significant differences in circumferential(P = 0.240) or radial (P = 0.808) strain estimates between the marker-based measurements and our novel noninvasive method. This method can thus be used for model validation as well as for studies of MV disease and repair.
Supplementary Figure 1, Table 1 from <i>De novo</i> Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel <i>In vivo</i> Breast Tumor Model (2023)

Supplementary Figure 1, Table 1 from &lt;i&gt;De novo&lt;/i&gt; Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel &lt;i&gt;In vivo&lt;/i&gt; Breast Tumor Model
Comparison Of Recruitment Patterns Of Rotator Cuff Versus Principal Shoulder Musculature During Active Humeral Motions (2005)

Introduction The rotator cuff muscles have been described as providing glenohumeral (GH) joint stability as their primary function and GH joint mobility as their secondary function. This ranking of stability over mobility as the functional role of the rotator cuff musculature suggests a pre-activation of the cuff muscles during active movements. Despite the widespread acceptance and emphasis that the contribution of these muscles to mobility is subordinate to their stabilizing function, there is a paucity in the scientific data to support such a claim. Purpose To determine if rotator cuff musculature preferentially and sequentially activates prior to the selection of other larger muscles that cross the GH joint during active, goal directed movements. To determine if the rotator cuffs activate in unison to stabilize the GH joint or with a motion specific pattern. Methods Six healthy subjects randomly performed humeral flexion (FL), abduction (AB) and extension (EX), and subsequently internal (IR) and external (ER) rotation in reaction to a light. EMG data from their dominant shoulders were collected from 3 rotator cuff muscles: supraspinatus (SS), infraspinatus (IS), and lower subscapularis (LS, two subjects), as well as the 3 portions of the deltoid (anterior: AD, middle: MD, posterior: PD) and the clavicular portion of the pectoralis major (PM). EMG onset times were determined by computing the RMS amplitude of the EMG signal followed by thresholding at a level of 5% MVC or the mean + 3 std of 0.5s of EMG prior to the light onset, whichever was higher. Results For each motion a significant main effect of muscle was found (ANOVA: FL p = 0.0038; AB p <0.001; EX p = 0.0272; ER p = 0.0056; IR n/a, n=2) indicating significant onset differences between muscles. The onset times are presented here in 3 categories: 0–50ms (c1), 50–100ms (c2) and >100ms (c3) relative to the first active muscle. Due to limited power only post-hoc differences (Bonferroni) could be found between the first (c1) and last (c3) onset categories. The activation patterns were found to be as follows: FL: [c1: SS, IS, LS, AD, PM; c2: MD; c3: PD], AB: [c1: SS, IS, MD, PD; c2: LS, AD; c3: PM], EX: [c1: SS, LS, MD, PD; c2: AD; c3: IS, PM], ER: [c1: SS, IS, MD, PD; c2: −; c3: LS, AD, PM], and IR: [c1: LS, PM; c2: AD; c3 -]. Conclusion Rotator cuff muscles and primary movers for each motion are activated within 50ms of each other. Antagonists are activated significantly later (>100ms). Rotator cuff activation onsets were found to be motion specific. Power analysis revealed that an additional 9 subjects are necessary to detect some of the timing differences (30ms) in the first onset category. These results will be presented at the conference.
HIV‐1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem‐diamino core structure (1997)

Two series of peptidomimetics containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure were prepared, from amino acid starting materials, and evaluated as inhibitors of HIV-1 protease (HIV-1 Pr). 1,1-Diamino-3-hydroxypropane (gHse) derivatives showed weak inhibitory potency (IC50 > 10 microM). In the 1,1-diamino-2-hydroxyethane (gSer) series, a compound containing P1/P1' benzyl and P2/P2'Fmoc substituents, displayed a significant HIV-1 Pr inhibition (IC50 = 440 nM).
A 57 GHz programmable frequency divider for fractional-N frequency synthesizers (2013)

A programmable frequency divider for the use in a fractional-N frequency synthesizer is presented. The measured input frequency range is from DC to 57 GHz for division factors in the entire integer range between 12 and 259 as well as 8 and 9. The frequency divider is based on a dual-modulus concept and has been realized in a SiGe bipolar technology (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> /f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> =170/250 GHz). The exceedingly high maximum input frequency has been reached by using emitter-coupled differential circuit technique with a consequent merging of logic operations and D flip-flops. The divider is designed for low power consumption of less than 300mW at a supply voltage of 3.3V. For the intended use in a fractional-N frequency synthesizer for the millimeter wave range, the division ratio is programmable via an 8 bit parallel interface to enable fast modulation of the division factor.
Injury‐induced Regulation of Ciliary Neurotrophic Factor mRNA in the Adult Rat Brain (1993)

Ciliary neurotrophic factor (CNTF) is a pleiotropic molecule that acts as a neurotrophic factor for a wide range of embryonic neurons as well as a differentiation factor for sympathetic neuroblasts and O2A progenitor cells in culture. CNTF messenger RNA (mRNA) is present at very low levels in the normal adult rat central nervous system (CNS), but is dramatically up-regulated after an aspiration lesion of dorsal hippocampus and overlying cortex, in the area coincident with glial scar. The increased level of CNTF mRNA in lesioned hippocampus is maximal by 3 days and is sustained for up to 20 days, the longest time point examined. In contrast, mRNA levels for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) were slightly decreased during the same period. In situ hybridization experiments revealed that cells expressing CNTF mRNA were concentrated at the margin of the wound, and also present within the gelfoam which filled the lesion cavity. This distribution of CNTF-expressing cells corresponded very closely to that of cells expressing high levels of glial fibrillary acidic protein mRNA at the wound site. Paralleling the observed increase in CNTF mRNA, increased levels of CNTF-like neurotrophic activity were apparent in soluble extracts of the lesioned tissues. This neurotrophic activity for ciliary ganglion neurons was completely blocked by the addition of neutralizing antiserum against CNTF. Basic fibroblast growth factor, which has been shown by others to increase after a similar lesion paradigm (Frautschy et al., Brain Res., 553, 291-299, 1991), does not contribute appreciably to this trophic activity.(ABSTRACT TRUNCATED AT 250 WORDS)
Superbanana Orbits in Stellarator Geometries (1979)

The presence of superbanana orbits localized to either the interior or the exterior of classical stellarators and torsatrons is investigated for 3.5-MeV $\ensuremath{\alpha}$ particles. The absence of the interior superbanana in both geometries is found to be related to nonconservation of the action. Exterior superbananas are found in the stellarator only, as a consequence of the existence of absolute localized magnetic wells. No superbananas of either type are found in the torsatron.
Partially-open SIW resonator for microwave characterization of particulate dielectrics: Effect of interaction with gases (2016)

This work describes a novel measurement technique for determining the complex permittivity of powdered materials, based on resonant-perturbation of a Substrate Integrated Waveguide (SIW) resonator operating at ~2.5 GHz and calculations from General Dielectric Mixture Model equations. The proposed method is validated with standard powder samples measurement and comparison with the measured data by 3D electromagnetic simulation. The influence of the powder density is also discussed. The technique is then used to investigate the effect of hydrogen gas adsorption and humidity on the dielectric properties of tin oxide and zinc oxide powders, respectively. The SIW-resonator is a low cost and simple structure with good sensitivity. It is adapted for dielectric characterizations of both semi-solid and non-solid materials.
Comparison of models and measurements of scatter from surface-bound particles (1998)

The paper reviews techniques to calculate differential scattering cross-section of sub-micron surface bound particles from scatter measurement. It discusses both the multiple and single particle measurement approaches to obtaining scatter data and the associated problems with each method. Measured results are compared to a scatter model based on the discrete source method. For spherical particles the model has very close agreement with the measured scatter. For non-spherical particles the agreement is close only for particle diameters smaller than about one fifth wavelength.
12B-2 Functional Doppler Imaging: A Feasibility Study (2007)

We have developed a new method, called 2D flow index mapping (2D-FIM), for quantitative imaging of functional hemodynamic indices, such as resistive index (RI), by retrospective analysis of power Doppler flow waveforms from one complete cardiac cycle. To evaluate this method, a feasibility study was performed in renal transplant patients undergoing routine duplex examination and normal volunteers. Baseband quadrature-demodulated ultrasound echoes were acquired from the parenchyma of the transplant kidneys (n=9) and from normal native kidneys (n=4). The RI values computed from arterial Doppler signals were measured using 2D-FIM. These indices showed a high correlation (Pearson's r=0.8, P<0.0004) with the values measured using spectral Doppler waveforms. Our preliminary results demonstrate the feasibility of 2D-FIM in renal transplant patients. Further refinement of these methods could lead to visualizing the functional hemodynamics in various complex vascular beds as well as for a more complete functional hemodynamic assessment in renal transplant patients.
Earthworm Type Micromachine Driven by Electro-conjugate Fluid (2007)

An electro-conjugate fluid (ECF) is a kind of functional fluid which generates a powerful jet flow when subjected to high DC voltage. Using this fluid, this paper proposes a novel earthworm-type peristaltic micromachine. First we describe a motion pattern of earthworm-type peristaltic micromachine, and propose a micro cell using ECF. The cell, composed of a fiber-reinforced silicone rubber tube, contracts in axial direction and expands in radial direction simultaneously by using the jet pressure of ECF. A large model prototype of earthworm-type peristaltic microma-chine having four cells in series, 10.2 [mm] in diameter and 90 [mm] in length, is developed and its basic driving characteristics are confirmed by experiments.
The Biology Hot Line: Use of a Telephone Answering Device in Large Classes (1984)

Two common challenges in teaching large lecture courses are student anonymity a d student heter ogeneity. Citing Thomas and Fink (6), McKeachie (4) reports that a group's use of resources is constrained because in a large group a smaller proportion of people can participate orally; and the larger the group, the less likely an individual feels free to volunteer. As the size of the class increases, the number and variety of student needs also increase. It is unlikely that the instructor's ability to meet differing expectations increases propor tionately, since class time is not expandable. Research studies conducted at three universities indi
Actuation and Sensing (2017)

Microactuators, microsensors, and signal processors have long been envisioned as the essential components of completely integrated microsystems.1 The schematic of a typical cell of a microintegrated optical system is shown in Fig. 4.1. It is composed of optical components, microactuators, microsensors, signal processors, and control electronics. The processor first receives a command from the outside world to achieve a certain goal, and then sends a command to the control electronics. Upon receiving this command, the microactuator may mechanically alter or displace the optical component to complete the task for the first cycle. At the same time, the microsensor examines if the requirements of the task have been fulfilled, and then the sensing signals are fed back to the signal processors to determine if the task is really completed or if another cycle is needed. Because of advances in both microelectronics and micro-electro-mechanical systems (MEMS) technologies, each cycle can be processed almost in real time. For example, an external command may arrive to select a specific wavelength as the data carrier in one optical channel in a communication network. The microactuator, controlled by electronics, then performs work on the optical component (e.g., actuates the MEMS-based tunable laser or filter) to choose a desired wavelength. The sensing signals from the microsensor are then fed back to the processor and used to determine if the goal has been reached. This chapter only covers two basic components in the microintegrated system: microsensors and microactuators. It distinguishes itself from other textbooks by categorizing microactuators from the point of view of optical applications and only covering one group of microsensors, which are based on optical sensing techniques.
Borg (2020)

This paper analyzes a newly-published trace that covers 8 different Borg [35] clusters for the month of May 2019. The trace enables researchers to explore how scheduling works in large-scale production compute clusters. We highlight how Borg has evolved and perform a longitudinal comparison of the newly-published 2019 trace against the 2011 trace, which has been highly cited within the research community.
Dipole‐dipole frequency‐domain EM sounding (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984Dipole‐dipole frequency‐domain EM soundingAuthors: James B. FinkConsultantWilliam H. PeltonJames B. FinkGeophynque International and William H. PeltonPhoenix Geophysics Inc.https://doi.org/10.1190/1.1894365 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1894365FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION James B. Fink and William H. Pelton, (1984), "Dipole‐dipole frequency‐domain EM sounding," SEG Technical Program Expanded Abstracts : 119-121. https://doi.org/10.1190/1.1894365 Plain-Language Summary PDF DownloadLoading ...
Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity (2020)

<i>Cis</i>-prenyltransferases such as undecaprenyl diphosphate synthase (UPPS) and decaprenyl diphosphate synthase (DPPS) are essential enzymes in bacteria and are involved in cell wall biosynthesis. UPPS and DPPS are absent in the human genome, so they are of interest as targets for antibiotic development. Here, we screened a library of 750 compounds from National Cancer Institute Diversity Set V for the inhibition of <i>Mycobacterium tuberculosis</i> DPPS and found 17 hits, and then IC<sub>50</sub>s were determined using dose-response curves. Compounds were tested for growth inhibition against a panel of bacteria, for <i>in vivo</i> activity in a <i>Staphylococcus aureus</i>/<i>Caenorhabditis elegans</i> model, and for mammalian cell toxicity. The most active DPPS inhibitor was the dicarboxylic acid redoxal (compound <b>10</b>), which also inhibited undecaprenyl diphosphate synthase (UPPS) as well as farnesyl diphosphate synthase. <b>10</b> was active against <i>S. aureus</i>, <i>Clostridiodes difficile</i>, <i>Bacillus anthracis</i> Sterne, and <i>Bacillus subtilis</i>, and there was a 3.4-fold increase in IC<sub>50</sub> on addition of a rescue agent, undecaprenyl monophosphate. We found that <b>10</b> was also a weak protonophore uncoupler, leading to the idea that it targets both isoprenoid biosynthesis and the proton motive force. In an <i>S. aureus</i>/<i>C. elegans in vivo</i> model, <b>10</b> reduced the <i>S. aureus</i> burden 3 times more effectively than did ampicillin.
Band lineup at an organic-inorganic semiconductor heterointerface: perylenetetracarboxylic dianhydride/GaAs(100) (1994)

We present a photoemission study of the electronic properties of an interface between the organic semiconductor; 3, 4, 9,10 perylenetetracarboxylic dianhydride (PTCDA) and n-type GaAs(100). We examine the evolution of the interface electron distribution as a function of PTCDA overlayer thickness. The highest occupied molecular orbital level of PTCDA is measured at 0.7±0.1 eV below the GaAs valence band maximum. The PTCDA ionization potential is measured at 6.4±0.15 eV. The discrepancy between the band alignment deduced from photoemission and transport measurement suggests that interface states or polarization effects play a role in determining the transport properties of the organic-inorganic heterojunction diodes.
The Art of Lecturing (2007)

This simple and clear guide to lecturing is an example-based account of effective strategies for exciting and successful lectures for academic and business lecturers. From the lecturing mindset, combating fear and nervousness, to lecturing tricks and tactics, this book discusses a wide array of practical ideas that may surprise and help even the most experienced public speakers and lecturers. The author provides unique insights into lecturing for twenty-first century audiences, based on his academic and non-academic lecturing experiences at the University of Toronto and Stanford University; experiences which have resulted in numerous institutional, provincial, and international teaching and lecturing awards. Further resources for this title, including lecture slides and videos of presentations and lectures, are available online from www.cambridge.org/9780521876100.
Rechargeable Batteries Using Robust but Redox Active Organic Radicals (2010)

This chapter contains sections titled: Introduction Redox reaction of organic radicals Mechanism and performance of an organic radical battery Molecular design and synthesis of redox active radical polymers A totally organic-based radical battery Conclusions References
Synthetic Routes for Designing Furanic and Non Furanic Biobased Surfactants from 5‐Hydroxymethylfurfural (2022)

5-hydroxymethylfurfural (HMF) is one of the most valuable biomass platform molecules, enabling the construction of a plethora of high value-added furanic compounds. In particular, in the last decade, HMF has been considered as a starting material for designing biobased surfactants, not only because of its renewability and carbon footprint, but also because of its enhanced biodegradability. This Review presents recent examples of the different approaches to link the hydrophilic and lipophilic moieties into the hydrophobic furan (and tetrahydrofuran) ring, giving a variety of biobased surfactants that have been classified here according to the charge of the head polar group. Moreover, strategies for the synthesis of different non-furanic structures surfactant molecules (such as levulinic acid, cyclopentanols, and aromatics) derived from HMF are described. The new HMF-based amphiphilic molecules presented here cover a wide range of hydrophilic-lipophilic balance values and have suitable surfactant properties such as surface tension activity and critical micelle concentration, to be an important alternative for the replacement of non-sustainable surfactants.