gebhart/patrepeval huggingface dataset:
Differences in Medicare Quality Measures among Nursing Homes afterPharmacogenetic Testing (2016)

Aim: Medical providers increasingly refer patients for pharmacogenetic testing. However, there is a dearth of data regarding the benefits of testing residents in long-term care facilities. The researchers conducted a retrospective population-level analysis to assess the usefulness of pharmacogenetic testing in nursing homes. Methods: A subset of publicly available data of nursing home quality measures was identified as being possibly associated with medication-related problems and pharmacogenetic variability. The overall quality measures for nursing homes that had initiated pharmacogenetic testing for residents via the YouScript® Personalized Prescribing System, pharmacogenetic testing (PGxT) were compared to measures from control nursing homes that had not initiated testing YouScript®, PGxT testing. Results: There was a 5.4% reduction in self-reported, moderate-to-severe pain in the residents of the PGxT nursing home compared to control homes that did not initiate testing YouScript®, PGxT testing (p=0.001). There was also a tendency towards a reduction in falls resulting in major injury in the YouScript®, PGxT nursing homes when compared against the national average. Conclusion: The present study demonstrated a small reduction in the percent of residents reporting moderateto- severe pain after results of pharmacogenetic testing were made available to the providers. Further studies will need to be done to assess if pharmacogenetic testing, using a Personalized Prescribing System, might reduce the use of potentially inappropriate medications and have a positive impact on the quality of life measures in the elderly.
Global Tn‐seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi (2016)

Borrelia burgdorferi maintains a complex life cycle between tick and vertebrate hosts. Although some genes have been identified as contributing to bacterial adaptation in the different hosts, the list is incomplete. In this manuscript, we report the first use of transposon mutagenesis combined with high-throughput sequencing (Tn-seq) in B. burgdorferi. We utilize the technique to investigate mechanisms of carbohydrate utilization in B. burgdorferi and the role of carbohydrate metabolism during mouse infection. We performed genetic fitness analyses to identify genes encoding factors contributing to growth on glucose, maltose, mannose, trehalose and N-acetyl-glucosamine. We obtained insight into the potential functions of proteins predicted to be involved in carbohydrate utilization and identified additional factors previously unrecognized as contributing to the metabolism of the tested carbohydrates. Strong phenotypes were observed for the putative carbohydrate phosphotransferase transporters BB0408 and BBB29 as well as the response regulator Rrp1. We further validated Tn-seq for use in mouse studies and were able to correctly identify known infectivity factors as well as additional transporters and genes on lp54 that may contribute to optimal mouse infection. As such, this study establishes Tn-seq as a powerful method for both in vitro and in vivo studies of B. burgdorferi.
Experiments of long distance wireless communication on spread spectrum (2013)

A spread spectrum technology is known to be able to expand the distance of wireless communications by improving the processing gain. However, the effective processing gain is decreased due to the phase shift between the two transceivers. We have studied the compensation algorithm of this phase shift, and its performance has been evaluated by a computer simulation. This paper shows some experimental results of wireless communication using spread spectrum with this algorithm on handheld transceivers.
Self-reconstructing sectioned Bessel beams offer submicron optical sectioning for large fields of view in light-sheet microscopy (2013)

One of main challenges in light-sheet microscopy is to design the light-sheet as extended and thin as possible - extended to cover a large field of view, thin to optimize resolution and contrast. However, a decrease of the beam's waist also decreases the illumination beam's depth of field. Here, we introduce a new kind of beam that we call sectioned Bessel beam. These beams can be generated by blocking opposite sections of the beam's angular spectrum. In combination with confocal-line detection the optical sectioning performance of the light-sheet can be decoupled from the depth of field of the illumination beam. By simulations and experiments we demonstrate that these beams exhibit self-reconstruction capabilities and penetration depths into thick scattering media equal to those of conventional Bessel beams. We applied sectioned Bessel beams to illuminate tumor multicellular spheroids and prove the increase in contrast. Sectioned Bessel beams turn out to be highly advantageous for the investigation of large strongly scattering samples in a light-sheet microscope.
Comparing 3D content creation interfaces in two virtual worlds: World of Warcraft and Second Life (2010)

In this article we compare the content creation systems of two popular virtual worlds: World of Warcraft and Second Life. We then discuss recommendations for three-dimensional (3D) content creation systems based on current trends in 3D user interface research. We hypothesize that by designing 3D content creation systems that follow these recommendations, virtual-world economies based on custom content creation (e.g., Second Life ) may be transformed, as more people will be able to create and modify content.
Smartmedia (2020)

Streaming media is gaining popularity, with numerous new services for video on demand and live broadcast. These services stream requested media content to user devices like smart TVs, personal computers and smartphones. Many of these devices are mobile devices, yet streaming media services do not adapt the delivered content to the context of the request, e.g., the location of the user, the time of the request or who are the people near the viewer. In this paper we illustrate how geofencing and geoblocking can be combined with adaptive streaming media to create a new technology of contextually-adapted streaming media. The new technology has the potential to create a new type of experience for streaming media by applying real-time modification of streamed content according to the viewer and the context, e.g., modify inappropriate content when the media is played in public places, change the length of a video played by a train passenger according to a train schedule, etc. The suggested technology can also be used for preventing password sharing in a non-intrusive way and for hyperlocal geoblocking, to facilitate copyright protection. We discuss the vision of modifying streaming media in real time based on the context, elaborate on some of the challenges in implementing this vision, and present novel applications of this new technology.
Packet loss performance due to buffer overflow at transmitter side of wireless link (2002)

The exact packet loss due to buffer overflow at the transmitter side of the wireless link is derived and a closed-form approximation for the corresponding wireless effective bandwidth is obtained. This discrete fluid flow analysis (FFA) is compared with existing continuous FFA and simulation analysis. Results show that packet loss performance by the discrete FFA is more accurate than that by the continuous FFA.
Cyclopeptide alkaloids. Synthetic, spectroscopic and conformational studies of phencyclopeptine model compounds (1980)

Peptide cyclization via the p-nitrophenyl ester of 4-methyl-3-[4&#x27;-{beta}-N-(N&#x27;-tert-butyloxycarbonyl-L~prolyl)-aminoethyl]phenoxy-pentanoic acid (9) has afforded a single cyclopeptide diastereomer,9R-isopropyl-5S,6-trimethylene-8-dearnino-1,2-dihydro-p-phencyclopeptine (4), in 36% yield. From the comparative analysis of the UV, IR, CD, and {sup 1}H NMR spectra of 4 and cyclopeptide 5S,6-trimethylene 8-deamino-1,2-dihydro-p-phencyclopeptine (3d), of known geometry, the conformational identities of the 14-membered ring systems were ascertained. From these data the assignment of R stereochemistry at C9 for cyclopeptide 4 was deduced. Since the stereochemistry at C9 in the naturally occurring phencyclopeptines is the same, these results suggest a feasible route to the stereoselective total synthesis of the phencyclopeptines.
On the application of pairing based cryptography to wireless sensor networks (2009)

Recent research results have shown that Elliptic Curve Cryptography (ECC) is feasible on resource constrained sensor nodes. In this work we demonstrate that the related but more complex primitives of Pairing Based Cryptography(PBC) are also well suited for sensor devices.We present the first in-depth study on the application and implementation of PBC to Wireless Sensor Networks (WSNs). Our implementations are all the fastest yet reported, and have been implemented across a range of WSN processors. On a system level we investigate the application of a simple non-interactive key exchange scheme that is particularly suitable for many WSN scenarios. We also present a novel variant of the key exchange protocol which can be useful in even more demanding applications, and which partially solves the problem of node compromise attacks.
Study of Minimum Mean Square Error Optimal Equalizers for 50Gbit/s High Speed Passive Optical Networks (2021)

We evaluated here the positive impact of MMSE equalizers on 50Gbit/s HS-PONs. Thanks to numerical simulations, we show that MMSE-LE and DFE allows to reach appreciable optical budget of 29dB for pre-FEC BER of 10 – 2 .
SP-333, a Proteolysis-resistant Agonist of Guanylate Cyclase-C, Inhibits Activation of NF-κB and Suppresses Production of Inflammatory Cytokines to Ameliorate DSS-induced Colitis in Mice (2012)

Purpose: Uroguanylin (UG) and guanylin (GN) are the physiological natriuretic peptides that activate guanylate cyclase-C (GC-C) to stimulate production of cyclic GMP, a second messenger known to mediate anti-inflammatory effects of cellular molecules such as nitric oxide and hemeoxygenase-1. Earlier we reported that UG expression is suppressed in human colon tumors and that the oral treatment with UG inhibited polyp formation in ApcMin/+ mice via a cGMP-mediated mechanism. Subsequently, we also reported that GC-C agonists (SP-304 and SP-333), highly potent analogs of UG, ameliorated GI inflammation in murine colitis models via downregulation of certain inflammatory cytokines. These results raised the possibility that SP-333 might inhibit NF-κB activation via stimulation of GC-C/cGMP signaling. Methods: Effect of oral treatment with SP-333 was evaluated in DSS-induced colitis in BDF1 mice. H&E stained colonic tissue sections were assessed for colitis by a pathologist blinded to treatment groups. Tissue sections were also scored for expression of Ki-67. Myeloperoxidase activity was measured in colon tissue. Intestinal explants were cultured for 24 hrs and levels of cytokines were measured in culture supernatants by ELISA. Human colon carcinoma T84 cells were treated with lipopolysaccharide (LPS) and SP-333 (0.1 to 10 μM) for 24 hrs and levels of cytokines secreted in the culture media were measured by ELISA. Cytosolic and nuclear fractions were isolated and levels of p-NF-κB-p65, IκB and IKKβ were measured by immunoblotting. Results: Oral treatment with SP-333 ameliorated DSS-induced colitis in mice. In T84 cells, treatment with SP-333 reduced levels of p-NF-κB-p65 in the nuclear fraction and increased levels of cytosolic IκB. Similar observations were made when cells were treated with 8-Br-cGMP, suggesting a cGMP-mediated mechanism to inhibit NF-κB activation and to reduce production of IL-17a, IL-8, IL-23 and TNF-α in T-84 cells. Conclusion: This is the first ever study to show that SP-333 treatment, through enhancement of GC-C/cGMP signaling, inhibits NF-κB activation and suppresses production of inflammatory cytokines to ameliorate DSS-induced colitis in BDF1 mice. SP-333 is currently being developed as an oral drug candidate for treatment of ulcerative colitis in humans. Disclosure: Dr. Kunwar Shailubhai is CSO of Synergy Pharmaceuticals, Inc.Figure: No Caption available.
Classification of small, vertical ISOs beneath the center of the MetalMapper 2×2 (2021)

Multiple incorrect classifications of vertical small ISO80 QC seed items located under the center of the MM2×2 sensor have occurred during cued AGC operations for FUDS MMRP remedial actions. For these failures the sensor QC tests and background data meet quality requirements and did not cause the misclassifications. This study examined the MM2×2 raw data and inversion results to determine why the QC seed items were not correctly classified as TOI. These classification failures are rare, but have several consistent characteristics, 1) the type of item, 2) the orientation of the item, and 3) the location of the item under the center of the MM2×2 sensor. This presentation describes experimental and modeling efforts that were performed to determine the cause of the misclassification and the extent of the problem. Namely, the primary and secondary EM signals are modeled and illustrated for the MM2×2 for this problematic configuration (vertical smallISO80 located 40cm below the center of the sensor). The modeling confirmed the expected symmetry of horizontal components of the primary magnetic field directly below the center of the sensors array and the relatively weak vertical component at that location. For this configuration, the target produces: a) the same vertical component in all four z-receivers, 2) equal and opposite sign horizontal components in x and y receivers, resulting the three independent equations and underdetermined (nine unknowns and three equations) ill-posed non-linear equations, see Figure 1. Three variables, item type; orientation; and item location were modified to evaluate how deviations from the perfectly symmetric configuration impact the misclassification problem. The results of this modeling and its relevance to classification with the MM2×2 on MMRP projects will be discussed in this presentation.
Wearable sweat monitoring sensor based on Ionic Liquid Gel (2016)

We fabricated wearable flexible humidity sensor that can measure human sweat. Our sensor is based on Ionic-Liquid-Gel coated Fabrics and Cloths (IG-Fabric / Cloth). We use EMIMBF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> as ionic liquid, which has a characteristic that it absorbs H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O and changes its impedance. We fabricated the humidity sensor on the surface of polyester T-shirt and measured the human's sweat transition when exercising and cooling down.
ChemInform Abstract: 1,1,3,3‐Tetraisopropyldisiloxane‐1,3‐diyl (TIPS) Migration Facilitates One‐Pot Formation of Enantiomerically Pure Methyl 2,3‐Epoxy‐D‐xylonate. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erratum: TMOF‐like factor controls the biosynthesis of serine proteases in the larval gut of Heliothis virescens (2001)

Abstract In our recently published paper, we the authors have found that in Table 3 there was a mistake in the statistical analysis of injected and control animals; they are not statistically different. Because of this faulty analysis, we initially did not find it necessary to include the 72 hour results that are highly statistically different. The amended Table 3 and the original article’s title page appear below.
Water Aging Reverses Residual Stresses in Hydrophilic Dental Composites (2013)

Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could result in deleterious stresses on restorative materials and tooth structure. The purpose of this experiment was to use the thin ring-slitting method to compare the residual stress generated within composite materials of varying hydrophilicity when aged in wet and dry conditions after polymerization. Water sorption, solubility, elastic modulus, and residual stresses were measured in 6 commercial composites/cements aged in water and dry conditions. The self-adhesive resin cement showed the highest water sorption and solubility. All composites showed initial residual contraction stresses, which were maintained when aged dry. Residual stresses in 2 of the self-adhesive cements and the polyacid-modified composite aged in wet conditions resulted in a net expansion. This experiment verified that residual shrinkage stresses in dental composites can be reversed during aging in water, resulting in a net expansion, with the effect directly related to their hydrophilic properties.
Alteration of Substrate Specificity of Galactose Oxidase by Chemical Cross-linking (1997)

Cross-linking chemical modification of galactose oxidase(GAO)in the presence of substrate was canied outand its substrate specificity was alnalyzed The substrate specificity of GAO was altered when cross-linking of GAO was mde in the presence of galactoseThe relative activity of native GAO for rafnose and melibiose wee about125 and80of the acdvity toward galactoserespectively In contrastthe reative activity fo-raffinose and melibiose of GAO which was cross-linked in the presence of galactose
Near-Infrared Fluorescent Rosol Dye Tailored toward Lymphatic Mapping Applications (2019)

An optical molecular imaging contrast agent that is tailored toward lymphatic mapping techniques implementing near-infrared (NIR) fluorescence image-guided navigation in the planning and surgical treatment of cancers would significantly aid in enabling the real-time visualization of the potential metastatic tumor-draining lymph node(s) for their needed surgical biopsy and/or removal, thereby ensuring unmissed disease to prevent recurrence and improve patient survival rates. Here, the development of the first NIR fluorescent rosol dye (THQ-Rosol) tailored to overcome the limitations arising from the suboptimal properties of the generic molecular fluorescent dyes commonly used for such applications is described. In developing THQ-Rosol, we prepared a progressive series of torsionally restrictive N-substituted non-NIR fluorescent rosol dyes based on density functional theory (DFT) calculations, wherein we discerned high correlations amongst their calculated energetics, modeled N-C3' torsion angles, and evaluated properties. We leveraged these strong relationships to rationally design THQ-Rosol, wherein DFT calculations inspired an innovative approach and synthetic strategy to afford an uncharged xanthene core-based scaffold/molecular platform with an aptly elevated p K<sub>a</sub> value alongside NIR fluorescence emission (ca.700-900 nm). THQ-Rosol exhibited 710 nm NIR fluorescence emission, a 160 nm Stokes shift, robust photostability, and an aptly elevated p K<sub>a</sub> value (5.85) for affording pH-insensitivity and optimal contrast upon designed use. We demonstrated the efficacy of THQ-Rosol for lymphatic mapping with in vitro and in vivo studies, wherein it revealed timely tumor drainage and afforded definitive lymph node visualization upon its administration and accumulation. THQ-Rosol serves as a proof-of-concept for the effective tailoring of an uncharged xanthene core-based scaffold/molecular platform toward a specific imaging application using rational design.
Emulating Access Grid features at web endpoints (2007)

In this paper we present a system that captures and processes streams from Access Grid virtual rooms (venues) and distributes them to web endpoints. Its distinctive advantage is the emulation of Access Grid features using standard web clients. The system includes a toolset to handle audio and video contents, demultiplex the different sources, transcode them to adequate formats and store the resulting multimedia streams in repositories in real-time. A specialized server delivers those streams to standard web browsers that synchronize them, emulating typical Access Grid features like multiple windows or dynamic video selection. Web browsers can compose multiple independent streams, providing the appearance of Access Grid presentations. This paper presents the design principles, the system architecture and our current implementation in detail.
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity (2021)

The novel human coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has caused a pandemic. There are currently several marketed vaccines and many in clinical trials targeting SARS-CoV-2. Another strategy is to repurpose approved drugs to decrease the burden of the COVID-19 (official name for the coronavirus disease) pandemic. as the FDA (U.S. Food and Drug Administration) approved antiviral drugs and anti-inflammatory drugs to arrest the cytokine storm, inducing the production of pro-inflammatory cytokines. Another view to solve these unprecedented challenges is to analyze the diverse nanotechnological approaches which are able to improve the COVID-19 pandemic. In this original minireview, as promising candidates we analyze the opportunity to develop biocompatible dendrimers as drugs themselves or as nanocarriers against COVID-19 disease. From the standpoint of COVID-19, we suggest developing dendrimers as shields against COVID-19 infection based on their capacity to be incorporated in several environments outside the patients and as important means to stop transmission of SARS-CoV-2.
Sensory consonance and the perceptual similarity of complex-tone harmonic intervals: Tests of adult and infant listeners (1996)

Two experiments examined the influence of sensory consonance on the perceptual similarity of simultaneous pairs of complex tones (harmonic intervals). In experiment 1, adults heard a sequence of five consonant intervals (each a perfect fifth, or 7 semitones) and judged whether a subsequently presented test interval was a member of the sequence. Discrimination performance was better when the test interval was dissonant (tritone, 6 semitones) rather than consonant (perfect fourth, 5 semitones), despite the fact that the change in interval width was twice as great for the consonant than for the dissonant comparison. In experiment 2, 7-month-old infants were tested with an operant headturn procedure in a similar design and exhibited an identical pattern of responding. Hence, for both age groups, consonance was more important than interval width in determining the perceived similarity of harmonic intervals.
Motion Control of Industrial Robot by Considering Vibration Suppression and Fast Path Tracking (2010)

This paper proposes a new motion control strategy for industrial robots. It is important to achieve rapid and accurate control of the motion of industrial robots. However, industrial robots often have vibration which is caused by the resonant frequency and nonlinear interference force from various joints of the robot. In this case, the notch filtering method for generating a reference is useful for suppressing the resonant phenomenon. However, the path tracking error of the robot motion increases because phase delay becomes large by using the notch filter.In order to overcome these problems, this paper proposes a zero-phase notch filter without phase delay for fast path tracking. Moreover, this paper proposes a fast position control method based on D-PD control with dynamic feed-forward compensation. Using these proposed strategies, this paper achieves fast and accurate robot motion control without vibration and overshoot.