gebhart/patrepeval huggingface dataset:
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza (2021)

Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is incompletely understood. Here, we collected bronchoalveolar lavage (BAL) fluids and parallel blood samples of critically ill COVID-19 patients requiring invasive mechanical ventilation and compared BAL fluid parameters with those of mechanically ventilated patients with influenza, as a non-COVID-19 viral pneumonia cohort. Compared with those of patients with influenza, BAL fluids of patients with COVID-19 contained increased numbers of hyperactivated degranulating neutrophils and elevated concentrations of the cytokines IL-1β, IL-1RA, IL-17A, TNF-α, and G-CSF; the chemokines CCL7, CXCL1, CXCL8, CXCL11, and CXCL12α; and the protease inhibitors elafin, secretory leukocyte protease inhibitor, and tissue inhibitor of metalloproteinases 1. In contrast, α-1 antitrypsin levels and net proteolytic activity were comparable in COVID-19 and influenza BAL fluids. During antibiotic treatment for bacterial coinfections, increased BAL fluid levels of several activating and chemotactic factors for monocytes, lymphocytes, and NK cells were detected in patients with COVID-19 whereas concentrations tended to decrease in patients with influenza, highlighting the persistent immunological response to coinfections in COVID-19. Finally, the high proteolytic activity in COVID-19 lungs suggests considering protease inhibitors as a treatment option.
Optical bistability on a silicon chip (2004)

We demonstrate, for the first time to our knowledge, optical bistability on a highly integrated silicon device, using a 5-microm-radius ring resonator. The strong light-confinement nature of the resonator induces nonlinear optical response with low pump power. We show that the optical bistability allows all-optical functionalities, such as switching and memory with microsecond time response and a modulation depth of 10 dB, driven by pump power as low as 45 microW. Silicon optical bistability relies on a fast thermal nonlinear optical effect presenting a 500-kHz modulation bandwidth.
Insect-controlled Robot: A Mobile Robot Platform to Evaluate the Odor-tracking Capability of an Insect (2016)

Robotic odor source localization has been a challenging area and one to which biological knowledge has been expected to contribute, as finding odor sources is an essential task for organism survival. Insects are well-studied organisms with regard to odor tracking, and their behavioral strategies have been applied to mobile robots for evaluation. This "bottom-up" approach is a fundamental way to develop biomimetic robots; however, the biological analyses and the modeling of behavioral mechanisms are still ongoing. Therefore, it is still unknown how such a biological system actually works as the controller of a robotic platform. To answer this question, we have developed an insect-controlled robot in which a male adult silkmoth (Bombyx mori) drives a robot car in response to odor stimuli; this can be regarded as a prototype of a future insect-mimetic robot. In the cockpit of the robot, a tethered silkmoth walked on an air-supported ball and an optical sensor measured the ball rotations. These rotations were translated into the movement of the two-wheeled robot. The advantage of this "hybrid" approach is that experimenters can manipulate any parameter of the robot, which enables the evaluation of the odor-tracking capability of insects and provides useful suggestions for robotic odor-tracking. Furthermore, these manipulations are non-invasive ways to alter the sensory-motor relationship of a pilot insect and will be a useful technique for understanding adaptive behaviors.
Carbonated structures in Paraguay: Durability strategies for maintenance planning (2018)

This work provides an analysis of results obtained in a set of carbonation tests performed in 38 concrete structures buildings located in the city of Asunción, Paraguay. This analysis has shown that structures present high values of carbonation depth, identifying the cover thickness as the most important parameter in terms of durability. Therefore, the aim of this paper is to give an outlook for optimal inspections in the context of maintenance strategies regarding carbonation-induced degradation of concrete structures in Paraguay. The optimisation problem is formulated through a quantification of cost components over the lifespan of structures, where the optimal inspection plan is considered when a minimum total expected cost of maintenance is accomplished.
N,N′-Bis(2,2,3,3,4,4,4-heptafluorobutyl)naphthalene-1,4:5,8-tetracarboximide (2008)

The title mol-ecule, C(22)H(8)F(14)N(2)O(4), lies across a crystallographic inversion center with the naphthalene diimide core essentially planar (mean deviation from plane is 0.0583 Å). The CF(2) groups in the perfluorobutyl chains are in an energetically favorable all trans conformation. In the crystal structure, mol-ecules are packed in slightly displaced layers so that the side chains overlap the aromatic naphthalene diimide rings, thus minimizing any possible π-π overlap.
Electronic Properties of Complex Crystalline and Amorphous Phases of Ge and Si. I. Density of States and Band Structures (1973)

We present calculations of the band structures and densities of states of Ge and Si in the diamond, wurzite, Si-III (BC-8), and Ge-III (ST-12) structures using the empirical-pseudopotential method and the tight-binding model used recently by Weaire. The increasing complexity of the crystal structures indicates that short-range disorder is able to account well for the density of states and optical properties of amorphous Ge and Si. This calculation also provides a method for explaining various features in the amorphous density of states and shows what structural aspects of the amorphous state are responsible for these features.
Energy intensity distribution on thinned X-ray mask substrate in 100 kV electron beam writing (2003)

In this work the authors have evaluated the energy intensity distributions on thinned x-ray masks by the combination of the dot exposure and line exposure methods in 100 kV electron beam writing.
ChemInform Abstract: One Pot Synthesis of Bioactive Benzopyranones Through Palladium‐Catalyzed C—H Activation and CO Insertion into 2‐Arylphenols. (2014)

Abstract The presented oxidative carbonylation of 2‐arylphenols proceeds under acid‐base free and mild conditions with a variety of substrates.
African Swine Fever Epidemiology and Control (2019)

African swine fever is a devastating disease that can result in death in almost all infected pigs. The continuing spread of African swine fever from Africa to Europe and recently to the high-pig production countries of China and others in Southeast Asia threatens global pork production and food security. The African swine fever virus is an unusual complex DNA virus and is not related to other viruses. This has presented challenges for vaccine development, and currently none is available. The virus is extremely well adapted to replicate in its hosts in the sylvatic cycle in East and South Africa. Its spread to other regions, with different wildlife hosts, climatic conditions, and pig production systems, has revealed unexpected epidemiological scenarios and different challenges for control. Here we review the epidemiology of African swine fever in these different scenarios and methods used for control. We also discuss progress toward vaccine development and research priorities to better understand this complex disease and improve control.
Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with time-dependent 3D computational fluid dynamics models (2004)

The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that stent geometry may cause local alterations in wall shear stress (WSS) that have been associated with neointimal hyperplasia and subsequent restenosis. However, previous CFD studies have ignored histological evidence of vascular straightening between circumferential stent struts. We tested the hypothesis that consideration of stent-induced vascular deformation may more accurately predict alterations in indexes of WSS that may subsequently account for histological findings after stenting. We further tested the hypothesis that the severity of these alterations in WSS varies with the degree of vascular deformation after implantation. Steady-state and time-dependent simulations of three-dimensional CFD arteries based on canine coronary artery measurements of diameter and blood flow were conducted, and WSS and WSS gradients were calculated. Circumferential straightening introduced areas of high WSS between stent struts that were absent in stented vessels of circular cross section. The area of vessel exposed to low WSS was dependent on the degree of circumferential vascular deformation and axial location within the stent. Stents with four vs. eight struts increased the intrastrut area of low WSS in vessels, regardless of cross-sectional geometry. Elevated WSS gradients were also observed between struts in vessels with polygonal cross sections. The results obtained using three-dimensional CFD models suggest that changes in vascular geometry after stent implantation are important determinants of WSS distributions that may be associated with subsequent neointimal hyperplasia.
Detailed diagnosis in enterprise networks (2009)

By studying trouble tickets from small enterprise networks, we conclude that their operators need detailed fault diagnosis. That is, the diagnostic system should be able to diagnose not only generic faults (e.g., performance-related) but also application specific faults (e.g., error codes). It should also identify culprits at a fine granularity such as a process or firewall configuration. We build a system, called NetMedic, that enables detailed diagnosis by harnessing the rich information exposed by modern operating systems and applications. It formulates detailed diagnosis as an inference problem that more faithfully captures the behaviors and interactions of fine-grained network components such as processes. The primary challenge in solving this problem is inferring when a component might be impacting another. Our solution is based on an intuitive technique that uses the joint behavior of two components in the past to estimate the likelihood of them impacting one another in the present. We find that our deployed prototype is effective at diagnosing faults that we inject in a live environment. The faulty component is correctly identified as the most likely culprit in 80% of the cases and is almost always in the list of top five culprits.
A prescription for turning self-pay accounts into revenue. (2010)

The antidote for a healthy bottom line is a streamlined payment recovery process from self-pay patients. Due to the current high unemployment rate and a resulting spike in self-pay patients, CFOs must be proactive and identify self-pay debt recovery solutions to stay in the black. It is vital to design an effective and efficient process that works for the specific needs of the hospital or practice. Utilizing metrics, reconditioning patients to pay at point-of-service, training associates to appropriately request payment, and understanding the limitations of the business office are key elements to financial health. Identifying an accounts receivable management partner could significantly reduce headaches and strain on staff and time.
Computational Studies of Water Adsorption in the Zeolite H-ZSM-5 (1996)

Ab initio molecular orbital calculations using Hartree−Fock theory and Møller−Plesset perturbation theory have been used to study the interaction of H2O with the Brønsted acid site in the zeolite H-ZSM-5. Aluminosilicate clusters with up to 28 T atoms (T = Si, Al) were used as models for the zeolite framework. Full optimization of a 3 T atom cluster at the MP2/6-31G(d) level indicates that the “ion-pair” structure, Z-···HOH2+, formed by proton transfer from the acid site of the zeolite (ZH) to the adsorbed H2O molecule, is a transition state, while the “neutral” adsorption structure, ZH···OH2, is a local energy minimum. Partial optimization of a larger 8 T cluster at the HF/6-31G(d) level also gave results suggesting that the ion-pair structure is a transition state. Calculations were carried out to obtain corrections for high levels of theory, zero-point energies, and larger cluster size. The resulting energy difference between the neutral and ion-pair structure is small (less than 5 kcal/mol and possibly close to zero). The interaction energy of ZH···OH2 is 13−14 kcal/mol, in agreement with experiment. We find that addition of a second H2O molecule to Z-···HOH2+ in the 3 T atom cluster stabilizes the ion-pair structure, Z-···H(OH2)2+, making it a local energy minimum. Finally, calculated vibrational frequencies for a 3 T atom cluster are used to help interpret experimental IR absorption spectra.
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists (2021)

Our data indicated that MAR709 and tirzepatide induce unique spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics relative to native peptides, semaglutide, and matched mono-agonist controls. These findings support the hypothesis that the structure of GLP-1/GIP dual-agonists confer a biased agonism that, in addition to its influence on intracellular signaling, uniquely modulates receptor trafficking.
Modeling absorbance-modulation optical lithography in photochromic films (2013)

A kinetic model describing the conversion of a photochromic layer under complex illumination conditions is applied to absorbance-modulation optical lithography to determine the influence of the material characteristics on the confinement to subdiffraction dimensions of the transmitted dose. We show that the most important parameters are the intensity ratio between the confining and writing beams, the overall absorption at the writing wavelength, the relative absorption coefficients, and the photoreaction quantum yields at the two wavelengths. As the confining beam ultimately determines the transferred dose pattern, we conclude that the modulation of the writing beam is not strictly necessary to produce subwavelength apertures.
Extraction and Identification of Water-Soluble Compounds in Palm-Pressed Fiber by SC-CO2 and GC-MS (2007)

The residual oil recovered from palm-pressed fiber is known to contain high level of carotenes (4,000 mg kgˉ1 to 6,000 mg kgˉ1) and vitamin E such as tocopherols and tocotrienols (2,000 mg kgˉ1 to 3,000 mg kgˉ1). In this study, the water-soluble compounds in fresh palm-pressed fiber were recovered by supercritical carbon dioxide (SC-CO2) extraction. The concentration of these compounds in palm-pressed fiber oil recovered was determined in the range of 1,000 mg kgˉ1 to 2,000 mg kgˉ1. A total of 12 compounds have been identified from this water-soluble extract with molecular weights ranging from 126 amu. to 208 amu.. Preliminary results showed that these water-soluble compounds possess superior antioxidant properties screening using FRAP (Ferric Reducing Ability of Plasma) and TEAC (Trolox Equivalent Antioxidant Capacity) assays.
<title>Radioscopy and computed tomography for failure analysis using microfocus x ray</title> (1996)

X-ray microfocus radioscopy and computed tomography (CT) offer detailed information on the internal assembly and material condition of objects under failure analysis investigation. Using advanced systems for the acquisition of radioscopic and CT images, failure analysis investigations are improved in technical accuracy at a reduced schedule and cost over alternative approaches. A versatile microfocus radioscopic system with CT capability has been successfully implemented as a standard tool in the Boeing Defense and Space Group Failure Analysis Laboratory. Using this tool, studies of electronic, electromechanical and composite material items have been performed. Such a system can pay for itself within two years through higher productivity of the laboratory, increased laboratory value to the company and resolution of critical problems whose worth far exceeds the value of the equipment. The microfocus x-ray source provides projection magnification images that exceed the sensitivity to fine detail that can be obtained with conventional film radiography. Radioscopy, which provides real-time images on a video monitor, allows objects to be readily manipulated and oriented for optimum x-ray evaluation, or monitored during dynamic processes to check performance. Combined with an accurate manipulating stage and data acquisition system x-ray measurements can be used for CT image reconstruction. The CT image provides a cross sectional view of the interior of an object without the interference of superposition of features found in conventional radiography. Accurate dimensional measurements and material constituent identification are possible from the CT images. By taking multiple, contiguous CT slices entire 3D data files can be generated of objects.
Incorporating User Utility Into Sponsored-Search Auctions (Short Paper) (2008)

We study principled methods for incorporating user utility into the selection of sponsored search ads. We describe variations of the GSP allocation/pricing mechanism that accommodate these user utility functions, we provide interesting and useful parallels of some of the theoretical properties from the traditional GSP mechanisms in the new GSP variations, and we present simulation results that exemplify the use of the ranking system.
New oral disease-modifying therapies for multiple sclerosis (2009)

Several promising, oral disease-modifying therapies for multiple sclerosis are currently being evaluated in clinical trials. The arrival of effective oral agents for multiple sclerosis will be a major advance in the global effort to alter the natural history of this chronic disease.
Choline Chloride Improves the Desiccation Tolerance of Chinese Hamster Ovary Cells (2010)

Recently there has been much interest in using sugars such as trehalose to preserve mammalian cells in a dry state as an alternative to cryopreservation (1–5). However, some studies indicate that sugars alone may not be sufficient to prevent cell injury during drying. Other factors like sodium toxicity, ionic imbalance and pH excursions during dehydration are a few of the mechanisms that have been hypothesized to decrease the viability of mammalian cells. In the present study, we investigated whether or not substituting sodium chloride with choline chloride (2-hydroxy-N, N,N-trimethylethanaminium chloride) in the preservation medium improves desiccation tolerance of Chinese Hamster Ovary (CHO) cells.
Two-photon fourth-order polarimetery (2005)

We demonstrate a fourth-order polarimeter that employs two-photon detection to measure the fourth-order polarization coherency matrix (FOCM) of an optical signal. We measure the FOCM of picosecond pulses subjected to polarization mode dispersion (PMD). The fourth-order polarimeter distinguishes different PMD states even when the state of polarization, including the degree of polarization, is constant.
Long fusion from sacrum to thoracic spine for adult spinal deformity with sagittal imbalance: upper versus lower thoracic spine as site of upper instrumented vertebra (2014)

Both the UT and LT groups demonstrated significant improvement in clinical and radiographic outcomes. A significant difference was not observed in improvement of clinical outcomes between the 2 groups.
Multidrug-resistance phenotype in Chinese hamster ovary cells. (1983)

Multidrug resistance is a complex pleiotropic phenotype of cross-resistance and collateral sensitivity to unrelated compounds observed in many mammalian cell mutants selected for resistance to single agents. In Chinese hamster ovary cells, colchicine-resistant mutants expressing this phenotype have been characterized extensively. Such mutants arise apparently from a single genetic event, and the basis of this phenotype appears to be localized at the membrane level, resulting in altered drug permeability. Expression of a 170,000-dalton surface glycoprotein (P-glycoprotein) has been identified to correlate with the multidrug-resistance phenotype. Selection of a second mutation in colchicine-resistant mutants, for resistance to phytohemagglutinin, results in an alteration of the carbohydrate moiety in P-glycoprotein and other surface components. This mutation does not noticeably affect the multi-drug-resistance phenotype. The altered permeability of mutant cells to drugs, however, can be modulated by nonionic detergents or metabolic inhibitors. These findings are consistent with a molecular mechanism of multidrug resistance whereby the pleiotropic response of the cell is mediated by an overexpression of a cell-surface protein, the P-glycoprotein.
Photoresponse at 1.55 &#x003BC;m in GeSn epitaxial films grown on Si (2007)

In summary, epitaxial Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> films with hole mobilities as high as 600 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> were deposited on Si(100) substrates by UHV-CVD and used to fabricate photoconductor devices employing standard semiconductor processing steps. Performance measurements of the produced device provided feedback for improvement of the Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> material quality during the growth. Photoconductor devices showed maximum 0.5% decrease of the resistance upon irradiation by 1.55 μm laser light with 5 mW power.
ChemInform Abstract: A Highly π‐Stacked Organic Semiconductor for Thin Film Transistors Based on Fused Thiophenes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.