gebhart/patrepeval huggingface dataset:
Abstract 784A: Profiling pancreatic cancer metabolism and tumor microenvironment for therapy (2012)

Abstract Pancreatic cancers have one of the highest fatality rates among all cancers and their response to therapies is highly variable. We have recently shown that inhibition of lactate dehydrogenase A (LDHA) and glutaminase (GLS) through small drug-like molecules causes pancreatic tumor regression. These studies indicate that targeting the metabolic reprogramming of cancer cells is a promising new approach to pancreatic cancer therapy. In order to translate these metabolic inhibitors to the clinic, our goal is to characterize and enable targeted selection of patients based on predicted metabolic response. Although genetic mutations may ultimately be the prime causes of early stage cancer, they can also lead to changes in cancer metabolism which enable cancer cells to proliferate and survive even under the hypoxic and nutrient-deprived conditions often encountered in the tumor microenvironment. The biochemical changes in cancer cells, which determine their behavior in terms of growth, survival and mobility, represent a functional readout of responses to external agents. We hypothesize that the metabolites of tumors that are sensitive to metabolic inhibitors are measurably different from those of resistant ones. We can therefore propose these metabolites as potential functional predictors of response. The proposed research will also study the metabolic reprogramming of cancer cells in the tumor microenvironment that can affect pancreatic cancer sensitivity to LDHA and GLS inhibition. The proposed experiments will use Metabolomics technology to trace the metabolic prototypes of pancreatic orthotopic xenografts to identify the metabolic signature of FX11 or BPTES-sensitive tumors as compared to resistant ones. For an analysis of the effects due to the tumor hypoxic microenvironment, we will use our innovative tool, the HypoxCR reporter system, which can simultaneously detect hypoxic cells and proliferating cells to define the effects of the pancreatic cancer tumor microenvironment on their sensitivity to metabolic inhibitors. This will be the first evaluation of the hypoxic tumor microenvironment in regards to how it affects the response of subfractions of pancreatic orthotopic xenograft tumor cells to metabolic inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 784A. doi:1538-7445.AM2012-784A
Analysis of Glenoid Fixation with Anatomic Total Shoulder Arthroplasty in an Extreme Cyclic Loading Scenario. (2015)

These results demonstrate that both cemented hybrid glenoids maintained fixation when tested according to each cyclic loading scenario, with no difference in post-cyclic displacement observed between designs. The lack of fatigue-related failures in these elevated load and high cycle test scenarios are promising, as are the relatively low displacements given the extreme nature of each test. This cyclic loading method is intended to supplement the ASTM F2028-14 standard that adequately simulates the rocking horse loading mechanism but may not adequately simulate the fatigue-related failure modes.
Targeted Drug Delivery through Optical Control of Cell Lysis (2020)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
Scalable Innovation (2016)

Innovation is a primary source of economic growth, and yet only one idea out of 3,000 becomes a successful product or service. Scalable Innovation: A Guide for Inventors, Entrepreneurs, and IP Professionals introduces a model for the innovation process, helping innovators to understand the nature and timing of opportunities and risks on the path to
Temperature dependence of phonon lifetimes in dielectric crystals (1995)

We present calculations of the temperature dependence of the lifetime of phonons due to anharmonic interactions. The contributions to the lifetime arising from phonon decay and phonon-phonon collisions are considered separately and, in addition, the relative strength of normal and umklapp processes is determined. The calculations are performed for an fcc lattice with nearest-neighbor central forces.
The long‐term postsurgical prognosis of patients with pineoblastoma (2011)

The current findings emphasize the importance of aggressive surgical resection in the treatment of pineoblastoma. In addition, the authors conclude that clinical trials should not mix young patients with older patients or patients who undergo subtotal resection with patients who undergo gross total resection, because such heterogeneity may alter the variability of responses to treatment and reduce the likelihood of success.
Physiological insulinemia acutely modulates plasma leptin. (1998)

Whether insulin acutely regulates plasma leptin in humans is controversial. We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men (age 42+/-2 years [mean+/-SE]; BMI 29.3+/-2.0 kg/m2). Each individual underwent four 9-h euglycemic clamps (insulin at 20, 40, 80, and 400 mU x m[-2] x min[-1) and a control saline infusion. Although plasma glucose and insulin levels remained constant, leptin diminished from 9.1+/-3.0 to 5.9+/-2.1 ng/ml (P < 0.001) by the end of the control experiment. Conversely, plasma leptin showed a dosage-dependent increase during the insulin infusions that was evident within 30-60 min. The insulin-induced increase in leptin was proportionately lower in obese insulin-resistant men. Free fatty acids (FFAs) decreased during insulin and did not change during saline infusions. ED50 (the dose producing half-maximal effect) for insulin's effect on leptin and FFA was similar (138+/-36 vs. 102+/-24 pmol/l, respectively; P=0.11). To further define the role of physiological insulinemia, we compared the effect of a very low dosage insulin infusion (10 mU x m[-2] x min[-1]) with that of a control saline infusion in another group of 10 men (mean age 39+/-3 years; BMI 27.1+/-1.0 kg/m2). Plasma leptin remained stable during that insulin infusion, but fell by 37+/-2% in the control experiment. Thus physiological insulinemia can acutely regulate plasma leptin. Insulin could mediate the effect of caloric intake on leptin and could be a determinant of its plasma concentration. Inadequate insulin-induced leptin production in obese and insulin-resistant subjects may contribute to the development or worsening of obesity.
"Advanced Design Techniques and Realizations of Microwave and RF Filters" - eBook WILEY & IEEE (2008)

443 pp
Mechanisms of Failure of the Femoral and Tibial Components in Total Knee Arthroplasty (1989)

From 1974 to 1986, 1430 cemented primary total knee arthroplasties were available for analysis. These included 224 total condylar prostheses with a polyethylene tibial component, 289 posterior stabilized prostheses with a polyethylene tibial component, and 917 posterior stabilized prostheses with a metal-backed tibial component. There were 12 failures in the total condylar series including three infections (one early and two late), five loose tibial components, two loose femoral and tibial components, and two unstable arthroplasties. The posterior stabilized prosthesis with the polyethylene tibia demonstrated six failures including two loose tibial components, two loose femoral components, and one supracondylar femur fracture. The posterior stabilized prosthesis with the metal-backed tibial component was associated with seven failures including six infections (three early and three late) and one femoral loosening. No metal-backed tibial components have been revised for loosening. The overall failure rate in this series was 1.7% for all prostheses. The incidence of tibial loosening was 0.53% with an average time to failure of 4.7 years. The incidence of femoral loosening was 0.35% with an average time to failure of 2.0 years. Tibial loosening was related to error in technique: postoperative varus tibiofemoral alignment, varus tibial component position, and excessive tibial resection. The overall infection rate was 0.63% for all total knee arthroplasties, and all were secondary to gram-positive organisms. Presently, the posterior stabilized prosthesis with a metal-backed tibia is the authors' implant of choice. Technical error and infection are the major causes of failure.
Node capture attacks in wireless sensor networks: A system theoretic approach (2010)

In this paper we address the problem of physical node capture attacks in wireless sensor networks and provide a control theoretic framework to model physical node capture, cloned node detection and revocation of compromised nodes. By combining probabilistic analysis of logical key graphs and linear control theory, we derive a dynamical model that efficiently describes network behavior under attack. Using LQR and LQG optimal control theory tools, we develop a network response strategy, which guarantees secure network connectivity and stability under attack. Detailed simulations are presented to validate the methodology.
Analysis of the Sites of Integration of Viral DNA Sequences in Rat Cells Transformed by Adenovirus 2 or SV40 (1980)

All cells transformed by adenovirus type 2 (Ad2) or SV40 carry viral DNA sequences. Often these sequences recombine with those of the host and are then passed on to the cells' descendants like any other part of the cellular genome (Sambrook et al. 1968). While a good deal is known of the number of integrated viral segments present in different cell lines and their general organization (Ketner and Kelly 1976; Botchan et al. 1976; Sambrook et al. 1977), nothing is known of the mechanism by which integration occurs, of the nature of the cellular attachment sites, of the exact locations of the integration sites in the viral genome, or of the mechanism by which viral DNA sequences are expressed. Direct access to the three latter problems has recently become possible with the development of techniques to propagate segments of eukaryotic DNA in prokaryotes
Integrated Photonic Electromagnetic Field Sensor Based on Broadband Bowtie Antenna Coupled Silicon Organic Hybrid Modulator (2014)

We present the design, fabrication and characterization of a compact and highly sensitive integrated photonic electromagnetic field sensor based on a silicon-organic hybrid modulator driven by a bowtie antenna. Slow-light effects in the electro-optic (EO) polymer refilled silicon slot photonic crystal waveguide (PCW), together with broadband electric field enhancement provided by the bowtie antenna, are utilized to enhance the interaction of microwaves and optical waves, enabling an ultra large effective in-device EO coefficient over 1000 pm/V and thus a high sensitivity. The EO polymer refilled slot PCW is designed for low-dispersion slow-light propagation, high poling efficiency, and high optical mode confinement inside the slot. The bowtie antenna acts not only as a receiving antenna, but also as poling electrodes during the fabrication process. A bowtie antenna integrated on doped silicon slot PCW is demonstrated to have a broad operational bandwidth, with a maximum resonance at the frequency of 10 GHz. The strongly enhanced broadband electric field is used to directly modulate the phase of the optical waves propagating through the slot PCW embedded inside the feed gap of the bowtie antenna. The phase modulation is then converted to intensity modulation using an external reference arm to form a Mach-Zehnder interferometer in our experimental setup. The sensing of electromagnetic field at 8.4 GHz is experimentally demonstrated, with a minimum detectable electromagnetic power density of 8.4 mW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , corresponding to a minimum detectable electric field of 2.5 V/m.
Design and Development of New Enantioselective Organocatalytic Transformations, a Two-Step Synthesis of Carbohydrates, and Progress toward the Total Synthesis of Callipeltoside C (2004)

The LUMO-lowering activation of a,b-unsaturated ketones has been accomplished through the development of a new imidazolidinone organocatalyst. That new imidazolidinone catalyst provided the first enantioselective catalytic Diels-Alder reaction with simple ketone dienophiles. Significantly, that catalyst is able to activate both cyclic and acyclic a, b-unsaturated ketones in this cycloaddition process. A new strategy for the synthesis of two privileged structural motifs, the polyketide and polyglycolate architectures, has been developed based on the direct aldehyde aldol reaction. Two different catalysts are presented that are capable of performing the enantioselective direct aldol cross coupling of two distinct aldehyde components. Imidazolidinones have been shown for the first time to initiate the HOMO-raising activation of both saturated and a, b-unsaturated aldehyde substrates. Using an imidazolidinone catalyst, the first direct enantioselective catalytic aldol coupling of two aldehydes is described and provides synthetically valuable b-hydroxy dimethylacetals. Later, proline was found to be an exceptionally effective catalyst for the direct aldehyde aldol reaction. In contrast to imidazolidinone catalysts, proline affords b-hydroxyaldehyde products that are primed for use directly in subsequent aldol reactions. Utilizing those direct aldehyde aldol methodologies, a two-step synthesis of 2,4,6-O-protected carbohydrates has been developed. Importantly, this modular strategy is capable of producing highly enantioenriched differentially protected forms of glucose, mannose, allose, mannosamine, as well as unnatural hexose derivatives. Furthermore, this method for sugar synthesis has been applied to the construction of differentially protected 13C6-labeled glucose, mannose, and allose in just four steps from labeled ethylene glycol. The enantioselective catalytic direct aldehyde aldol reaction was further applied toward the total synthesis of the marine natural product callipeltoside C. Several key fragments have been successfully synthesized and coupled to form macrolactone precursors. Nozaki-Hiyama-Kishi ring closure across the C-9/C-10 bond, however, affords exclusively the undesired C-9 epimer. Therefore, completion of the total synthesis will require a revised order for fragment assembly.
Phytochemicals Isolation from Leaves of Girardinia Heterophylla (2013)

A chemical study was done on the leaves of Girardinia heterophylla commonly called as Dans Kandali in Uttarakhand. The separation of chemical compounds was carried out by different chromatographic techniques and their structures were elucidated by spectroscopic methods. The three compounds, β-sitosterol, (24R)-Ergost-5-en-3-β-ol)/Campesterol and chlorogenic acid isolated from the leaves of Girardinia heterophylla . Key words: Girardinia heterophylla, β-sitosterol, (24R)-Ergost-5-en-3-β-ol, chlorogenic acid.
An Efficient Method for LED Light Sources Characterization (2019)

Digital LED drivers capable of blending the spectrum of two LED fixtures with different Correlated Color Temperatures through the LEDs’ power supply control are widespread. However, the digital control of lighting systems is possible only after a careful study of the LED’s response, in terms of illuminance and Correlated Color Temperature. The proposed work takes advantage of the Tunable White technology for the realization of an efficient method for LED light source characterization. In order to evaluate how the light changes as a function of the electric power supplied by the LED drivers, an experimental setup to characterize LED light sources has been designed. Starting from the data acquired from the experimental setup, a model for dimming the LED driver and obtaining the desired values of quality of light has been developed. The proposed model is based on the least squares method and its accuracy is evaluated by comparing the obtained values of illuminance and Correlated Color Temperature with those measured by an illuminance spectrophotometer. Results achieved an error of 0.3% for Correlated Color Temperature and 1.5% for illuminance using the proposed approximation functions.
Nonlinear power amplifier sensitivity and effects on behavioural model performance (2011)

Behaviroual modelling of power amplifiers is significant for performance estimation efficiency. The numerical error is efficient to characterize a power amplifier models and signal effects. Based on this characteristics, a different performance driven iterative methods for model parameters estimation are presented. We introduce methods for the matrix inversion problems of the model coefficients estimation. Indeed, due to numerical instability of system resoltuion in matrix inversion, two alternatives techniques are proposed to avoid the direct constructions of the extreme ill-conditioning. Accurate characterization based on both orthogonal and conventional plynomial basis are applied to model PAs. Simulation results with real multi-carrier WCDMA signals are applied for coefficients extraction with improved numerical stability. The effects of the signal characteristics on the performance of the device under test (DUT) are demonstrated.
Conditions for designing strictly positive real transfer functions for adaptive output error identification (1987)

Strictly positive real (SPR) transfer functions are of importance in Adaptive systems theory. This paper addresses two issues related to finding a polynomial <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b(s)</tex> such that <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b(s)/a(s)</tex> is SPR for all <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a(s)</tex> belonging to a set of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> th-degree Hurwitz polynomials <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">{\P}^n</tex> defined by the magnitude bounds on the coefficients of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a(s)</tex> . It is shown that irrespective of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> there exist four polynomials in <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">{\P}^n</tex> such that if the ratios of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b(s)</tex> with each of these is SPR then <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b(s)/a(s)</tex> is SPR for all members of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">{\P}^n</tex> . A sufficient condition for the existence of this <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b(s)</tex> along with a method for its construction is outlined. The condition resembles the Routh array test for determining system stability.
Membrane potential generation coupled to oxidation of external NADH in liver mitochondria (1998)

Oxidation of added NADH by rat liver mitochondria has been studied. It is found that exogenous NADH, when oxidized by rat liver mitochondria in sucrose hypotonic medium supplemented with Mg2+ and EGTA, generates a membrane potential (delta psi) even in the absence of added cytochrome c. ADP and phosphate decrease delta psi, the effect being reversed by oligomycin. Rotenone and myxothiazol do not inhibit delta psi generated by oxidation of exogenous NADH. Added cytochrome c increases the rate of the exogenous NADH oxidation and coupled delta psi formation. In sucrose isotonic medium, or in hypotonic medium without Mg2+, exogenous NADH fails to stimulate respiration and to form a membrane potential. In the presence of Mg2+, exogenous NADH appears to be effective in delta psi generation in isotonic sucrose medium if mitochondria were treated with digitonin. In isotonic KCl without Mg2+, oxidation of exogenous NADH is coupled to the delta psi formation and MgCl2 addition before mitochondria prevents this effect. In hypotonic (but not in isotonic) sucrose medium, Mg2+ makes a portion of the cytochrome c pool reducible by exogenous NADH or ascorbate. It is assumed that (i) hypotonic treatment or digitonin causes disruption of the outer mitochondrial membrane, and, as a consequence, desorption of the membrane-bound cytochrome c in a Mg2+-dependent fashion; (ii) incubation in isotonic KCI without Mg2+ results in swelling of mitochondrial matrix, disruption of the outer membrane and cytochrome c desorption whereas Mg2+ lowers the K+ permeability of the inner membrane and, hence, prevents swelling; (iii) desorbed cytochrome c is reduced by added NADH via NADH-cytochrome b5 reductase and cytochrome b5 or by ascorbate and is oxidized by cytochrome oxidase. The role of desorbed cytochrome c in oxidation of superoxide and cytoplasmic NADH as well as possible relations of these events to apoptosis are discussed.
Human FcvarepsilonRIalpha-Specific Human Single-Chain Fv (scFv) Antibody with Antagonistic Activity toward IgE/FcvarepsilonRIalpha-Binding (2003)

The alpha-chain of Fc epsilon RI (Fc epsilon RIalpha) plays a critical role in the binding of IgE to Fc epsilon RI. A fully human antibody interfering with this interaction may be useful for the prevention of IgE-mediated allergic diseases. Here, we describe the successful isolation of a human single-chain Fv antibody specific to human Fc epsilon RIalpha using human antibody phage display libraries. Using the non-immune phage antibody libraries constructed from peripheral blood lymphocyte cDNA from 20 healthy subjects, we isolated three phage clones (designated as FcR epsilon 27, FcR epsilon 51, and FcR epsilon 70) through two rounds of biopanning selection. The purified soluble scFv, FcR epsilon 51, inhibited the binding of IgE to recombinant Fc epsilon RIalpha, although both FcR epsilon 27 and FcR epsilon 70 showed fine binding specificity to Fc epsilon RIalpha. Since FcR epsilon 51 was determined to be a monomer by HPLC, BIAcore analysis was performed. The dissociation constant of FcR epsilon 51 to Fc epsilon RIalpha was estimated to be 20 nM, i.e., fortyfold lower than that of IgE binding to Fc epsilon RIalpha (K(d) = 0.5 nM). With these characteristics, FcR epsilon 51 exhibited inhibitory activity on the release of histamine from passively sensitized human peripheral blood mononuclear cells.
An anomaly in the necking behavior of polyethylene, Part 3 (1980)

Abstract Differential scanning calorimetry (DSC) measurements, polarized light microscopy and scanning electron microscopy (SEM) studies are reported on neck fibers formed by constant uniaxial tensile loading of polyethylene specimens at temperatures ranging from 298 to 353 K. The DSC measurements indicate that the temperature of the melting peak ( T peak ) of the neck fibers is closely related to the fibrilinity, i.e., the content of complete fibrillar structure, and that T peak and thus fibrillinity of the fractured neck fibers is sensitive to the nominal stress in the region of marked transition. A previously proposed hypothesis concerning the appearance of a marked transition in the necking/fracture behavior of high density and high molecular weight polyethylene is thereby supported. The polarized light microscopy showed a correlation between the zone length of the transformation from spherulitic to fibrillar structure and the previously reported distinctness in neck formation. The crystallinity determinations obtained from the DSC measurements and the SEM observations confirmed the suggestion previously made that the density decrease in the fractured neck fibers of a high density polyethylene with M n = 21.6 × 10 3 and M w = 199 × 10 3 is a result of void formation.