gebhart/patrepeval huggingface dataset:
Recent advances in the polymerization of elemental sulphur, inverse vulcanization and methods to obtain functional Chalcogenide Hybrid Inorganic/Organic Polymers (CHIPs) (2019)

Recent developments in the polymerization of elemental sulfur, inverse vulcanization and functional Chalcogenide Hybrid Inorganic/Organic Polymers (CHIPs) are reviewed.
A hybrid quantum photonic interface for $^{171}$Yb solid-state qubits (2022)

$^{171}$Yb$^{3+}$ in YVO$_4$ is a promising candidate for building quantum networks with good optical addressability, excellent spin properties and a secondary nuclear-spin quantum register. However, the associated long optical lifetime necessitates coupling to optical resonators for faster emission of single photons and to facilitate control of single $^{171}$Yb ions. Previously, single $^{171}$Yb ions were addressed by coupling them to monolithic photonic crystal cavities fabricated via lengthy focused ion beam milling. Here, we design and fabricate a hybrid platform based on ions coupled to the evanescently decaying field of a GaAs photonic crystal cavity. We experimentally detect and demonstrate coherent optical control of single $^{171}$Yb ions. For the most strongly coupled ions, we find a 64 fold reduction in lifetime. The results show a promising route towards a quantum network with $^{171}$Yb:YVO$_4$ using a highly scalable platform.
MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease (2013)

The present study examined whether matrix metalloproteinase-3 (MMP-3) participates in the loss of dopaminergic (DA) neurons in the nigrostriatal pathway in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease with blood brain barrier (BBB) damage and infiltration of peripheral immune cells. Tyrosine hydroxylase (TH) immunostaining of brain sections from MPTP-treated mice showed that MPTP induced significant degeneration of nigrostriatal DA neurons. Moreover, FITC-labeled albumin detection and immunostaining revealed that MPTP caused damage to the BBB and increased the number of ED-1- and CD-3-immunopositive cells in the substantia nigra (SN). Genetic ablation of MMP-3 reduced the nigrostriatal DA neuron loss and improved motor function. This neuroprotective effect afforded by MMP-3 deletion was associated with the suppression of BBB disruption and a decrease in the number of ED-1- and CD-3-immunopositive cells in the SN. These data suggest that MMP-3 could play a crucial role in neurodegenerative diseases such as PD in which BBB damage and neuroinflammation are implicated.
Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups (2010)

UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases (ppGalNAcTs, EC 2.4.1.41), a family of key enzymes that initiate posttranslational modification with O-glycans in mucin synthesis by introduction of alpha-GalNAc residues, are structurally composed of a catalytic domain and a lectin domain. It has been known that multiple Ser/Thr residues are assigned in common mucin glycoproteins as potential O-glycosylation sites and more than 20 distinct isoforms of this enzyme family contribute to produce densely O-glycosylated mucin glycoproteins. However, it seems that the functional role of the lectin domain of ppGalNAcTs remains unclear. We considered that electron capture dissociation mass spectrometry (ECD-MS), a promising method for highly selective fragmentation at peptide linkages of glycopeptides to generate unique c and z series of ions, should allow for precise structural characterization to uncover the mechanism in O-glycosylation of mucin peptides by ppGalNAcTs. In the present study, it was demonstrated that a system composed of an electrospray source, a linear RFQ ion trap that isolates precursor ions, the ECD device, and a TOF mass spectrometer is a nice tool to identify the preferential O-glycosylation sites without any decomposition of the carbohydrate moiety. It should be noted that electrons used for ECD are accelerated within a range from 1.75 to 9.75 eV depending on the structures of glycopeptides of interest. We revealed for the first time that additional installation of a alpha-GalNAc residue at potential glycosylation sites by ppGalNAcT2 proceeds smoothly in various unnatural glycopeptides having alpha-Man, alpha-Fuc, and beta-Gal residues as well as alpha-GalNAc residues. The results may suggest that ppGalNAcT2 did not differentiate totally presubstituted sugar residues in terms of configuration of functional groups, d-, l-configuration, and even alpha-, beta-stereochemistry at an anomeric carbon atom when relatively short synthetic peptides were employed for the acceptor substrates. Unexpected characteristics of ppGalNAcT2 motivated us to challenge site-directed installation of alpha-GalNAc residues at desired position(s) by protecting some hydroxyl groups of Thr/Ser residues with selectively removable sugars, notably a novel concept as "carbohydrate as protective groups", toward a goal of the systematic chemical and enzymatic synthesis of biologically important mucin glycopeptides.
An Analytical Approach for the Design of Class-E Resonant DC–DC Converters (2016)

We present a new approach to design resonant dc-dc converters, that allows us to achieve both a more accurate implementation and a simpler architecture, by reducing the number of required passive components. The approach is applied to a class-E topology, and it is based on the analytic solution of the system of differential equations regulating the converter evolution. Our technique is also capable of taking into account the most important circuit nonidealities. This represents an important breakthrough with respect to the state of the art, where class-E circuit analysis is based on strong simplifying assumptions, and the final circuit design is achieved by means of numerical simulations after many time-consuming parametric sweeps. The developed methodology is dimensionless, and the achieved design curves can be denormalized to easily get the desired circuit design. Measurements on two different prototypes confirm an extremely high adherence to the developed mathematical approach.
Tissue Engineering: Mineral Coatings for Temporally Controlled Delivery of Multiple Proteins (Adv. Mater. 37/2011) (2011)

Bioresorbable mineral coatings on a common orthopedic biomaterial, β-tricalcium phosphate (β-TCP), are used as a temporally controllable protein delivery system. As reported by William L. Murphy and coworkers, mineral coatings can effi ciently bind the proteins, and one or more proteins are released with distinct kinetics by varying the mineral coating properties and incorporating proteins during coating formation.
Structural analysis of the (dA)1j02(dT)10 triple helix (UV mixing curve/helix-coil transition/imino proton NMR/nuclear Overhauser effect spectroscopy/Hoogsteen base pair) (2016)

The existence of DNA triple helices in vitro has been known for some time. Recent evidence suggesting that DNA triplexes exist in vivo and showing their potential for chemotherapeutic applications has renewed interest in these triple-stranded conformations. However, little structural in- formation is currently known about these unusual nucleic acid forms. We have induced and stabilized triple-helical (dA)102(dT)lo with MgCl2 at neutral pH. UV mixing curves demonstrate a 1:2 (dA)1o to (dT)10 stoichiometry at suitable MgCl2 concentrations. Thermal denaturation profiles establish a melting mechanism characterized by the initial loss of the third strand, followed by dissociation of the remaining duplex. The circular dichroic spectrum of the triplex form is distinct from that of a duplex equimolar in (dA)10. NMR studies show that magnesium-induced triplex formation is accompanied by an upfield shift of several imino proton resonances present before stabilization of the triplex form with MgCl2 and the induction of new upfield imino proton resonances. Nuclear Overhauser effect spectroscopy measurements on both undeu- terated and C8-H-deuterated (dA)102(dT)lo triplexes demon- strate dipolar contacts between resolvable imino proteins and both adenine C8-H and C2-H aromatic protons. Hence, MgCl2 stabilizes a triplex structure in which thymine N3-H imino protons are involved in both Watson-Crick and Hoogsteen base pairing.
The Failure of Success (2015)

Abstract This chapter describes how Nonconformity was losing its contact with the poorer sections of society. While the Nonconformist registers indicate that in the first four decades of the nineteenth century the appeal of Nonconformity was very largely to people who were poor, ill-educated, and superstitious, those registers show that by the end of the century, the working-class element in Dissenting chapels was likely to be dominated by respectable, intelligent, skilled workers and their families.
The power of linear programming for valued CSPs: a constructive characterization (2012)

A class of valued constraint satisfaction problems (VCSPs) is characterised by a valued constraint language, a fixed set of cost functions on a finite domain. An instance of the problem is specified by a sum of cost functions from the language with the goal to minimise the sum. We study which classes of finite-valued languages can be solved exactly by the basic linear programming relaxation (BLP). Thapper and Zivny showed [20] that if BLP solves the language then the language admits a binary commutative fractional polymorphism. We prove that the converse is also true. This leads to a necessary and a sufficient condition which can be checked in polynomial time for a given language. In contrast, the previous necessary and sufficient condition due to [20] involved infinitely many inequalities. More recently, Thapper and Zivny [21] showed (using, in particular, a technique introduced in this paper) that core languages that do not satisfy our condition are NP-hard. Taken together, these results imply that a finite-valued language can either be solved using Linear Programming or is NP-hard.
Xestospongin B, a competitive inhibitor of IP3‐mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108‐15) cells (2005)

Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP(3))-induced Ca(2+) release. In a concentration-dependent manner xestospongin B displaced [(3)H]IP(3) from both rat cerebellar membranes and rat skeletal myotube homogenates with an EC(50) of 44.6 +/- 1.1 microM and 27.4 +/- 1.1 microM, respectively. Xestospongin B, depending on the dose, suppressed bradykinin-induced Ca(2+) signals in neuroblastoma (NG108-15) cells, and also selectively blocked the slow intracellular Ca(2+) signal induced by membrane depolarization with high external K(+) (47 mM) in rat skeletal myotubes. This slow Ca(2+) signal is unrelated to muscle contraction, and involves IP(3) receptors. In highly purified isolated nuclei from rat skeletal myotubes, Xestospongin B reduced, or suppressed IP(3)-induced Ca(2+) oscillations with an EC(50) = 18.9 +/- 1.35 microM. In rat myotubes exposed to a Ca(2+)-free medium, Xestospongin B neither depleted sarcoplasmic reticulum Ca(2+) stores, nor modified thapsigargin action and did not affect capacitative Ca(2+) entry after thapsigargin-induced depletion of Ca(2+) stores. Ca(2+)-ATPase activity measured in skeletal myotube homogenates remained unaffected by Xestospongin B. It is concluded that xestospongin B is an effective cell-permeant, competitive inhibitor of IP(3) receptors in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells.
Perspectives on the phase 0 clinical trial of microdose administration of ABY-029 for fluorescence guided surgery: stability testing (2020)

ABY-029, an anti-epidermal growth factor receptor (EGFR) Affibody molecule labeled with IRDye 800CW, has been used in three Phase 0 microdosing clinical trials for fluorescence guided surgery. In May of 2019, the clinical trials were put on hold because the ABY-029 produced under Good Manufacturing Practices (GMP) for human administration had come to the end of term in which the drug product was known to be stable. Stability testing was halted due to limitations in supply of a suitable reference standard and a required test product being discontinued from commercial sale. In order to complete the remaining patients in the three clinical trials, new stability tests were developed and the GMP batch of ABY-029 drug product tested under the new protocols. The GMP batch of ABY-029 passed all stability tests under the new protocols and the Federal Drug Administration (FDA) has given permission to complete the remaining patients with stability testing of ABY-029 performed for each patient. The tests developed and used to test ABY-029 drug product stability are described here.
Design and performance parameters of an ultra-low voltage, single supply 32bit processor implemented in 28nm FDSOI technology (2015)

This work presents a single-supply SPARC 32b V8 microprocessor designed with Ultra Low Voltage (ULV) adapted standard cells and memories, aiming at low energy operation and stand by power. The microprocessor, equipped with 10 Transistors ULV bitcell 8KB SRAM cache, has been fabricated in Fully Depleted Silicon On Insulator (FDSOI) 28nm technology. A comparative analysis with similar implementations has been provided highlighting the performance gain and power savings that are achieved by our design methodology and implementation technology. Wafer-level tests showed that our ULV adapted microprocessor has an operating range that is functional down to 0.33V and that the ULV able cache can save from 30% to 62% energy.
Efficient Solid-Phase Synthesis of a Library of Imidazo[1,2-a]pyridine-8-carboxamides (2007)

A versatile method for the solid-phase synthesis of imidazo[1,2-a]pyridine-based derivatives, imidazo[1,2-a]pyridine-8-carboxamides, has been developed. They were obtained by treatment of the amino group of the polymer-bound 2-aminonicotinate with different alpha-haloketones, followed by halogenation at the 3-position of the polymer-bound imidazo[1,2-a]pyridine. The derived polymer-bound imidazo[1,2-a]pyridines 5, 6, and 7 were finally cleaved from the solid-support with an excess of primary or secondary amines. The final crude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE).
Common-Mode Noise Reduction Using Voltage-Limited Remote-State PWM in Wide Voltage Utilization Region for Motor Drives (2023)

This paper proposes a method of achieving both common-mode (CM) noise reduction and a high-voltage utilization ratio for electric compressors in vehicle air conditioners. The voltage output from the non-linear region is effectively utilized by considering both the modulator, which is based on previous studies, and the outer current controller. The proposed method consists of a simple time limiter to achieve remote-state (RS) pulse width modulation (PWM), feedback on the voltage error caused by the limiter, and a rotation direction detector to determine the voltage vector to use. As the current controller is designed using the conventional method, the proposed method is easily introduced. The effectiveness of the proposed method is compared with the conventional methods—continuous PWM (CPWM), discontinuous PWM (DPWM), and RSPWM—through experimental evaluations. The results show that the proposed method reduces CM noise by approximately 10dB in the frequency range of several hundred kHz to several MHz without additional circuits. Moreover, the proposed method has higher speed range than RSPWM and achieves the maximum voltage utilization ratio of DPWM.
Fabrication and Recording of Bit Patterned Media Prepared by Rotary Stage Electron Beam Lithography (2011)

Bit patterned media (BPM) is a promising technology for hard disk drive recording at ultra-high areal densities of 1 Tbit/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and beyond. However, for BPM to be commercially viable, nanoscale bit patterns must be fabricated at low cost on a large scale and with low defect densities. The most likely route to realizing such criteria is through the use of high throughput nanoimprint lithography followed by direct etching of the recording media, where the bit pattern template is generated by highly accurate electron beam mastering tools. In this work, we experimentally demonstrate the merits of rotary stage electron beam mastering and the subsequent effects of direct pattern transfer on BPM and servo arrays patterned into 2.5" commercially available CoCrPt perpendicular recording media (PRM) at a density of 366 Gbit/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The 42 nm pitch staggered bit patterns and corresponding servo arrays were lithographically generated by a Pioneer Corporation EBR-401 rotary stage electron beam mastering system and subsequently transferred into the media using a series of reactive ion etching and ion milling processes with C/SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> mask structures and a novel Al protection layer. The fabricated media was recorded and read back with a commercial recording head to verify pattern fidelity.
Insights into salt tolerance from the genome of Thellungiella salsuginea (2012)

Thellungiella salsuginea, a close relative of Arabidopsis, represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled based on ~134-fold coverage to seven chromosomes with a coding capacity of at least 28,457 genes. This genome provides resources and evidence about the nature of defense mechanisms constituting the genetic basis underlying plant abiotic stress tolerance. Comparative genomics and experimental analyses identified genes related to cation transport, abscisic acid signaling, and wax production prominent in T. salsuginea as possible contributors to its success in stressful environments.
Influence of stacking faults on the performance of 4H–SiC Schottky barrier diodes fabricated on (1120) face (2002)

The influence of stacking faults (SFs) on the performance of 4H–SiC (112̄0) Schottky barrier diodes fabricated on the epilayer grown on the substrate which was grown in [112̄0] direction by the sublimation method was investigated. The number of SFs under the Schottky electrode was determined by KOH etching of (11̄00) face cross section. SFs were found to have a severe influence on the leakage current of reverse characteristic and Schottky barrier height. The leakage current is increased even though a few SFs exist under the electrode. The Schottky barrier height is also affected by the SF under the electrode.
First World Congress on Ultrasonics—Berlin, Septemer 1995 (1996)

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Experimental Study of the Limits of Digital Nonlinearity Compensation in DWDM Systems (2015)

We experimentally investigate idealized digital nonlinearity compensation in a 9-channel DWDM system. A Q2-factor gain of 2-dB for single-channel transmission is reduced to 0.1-dB in DWDM operation and recovers to 0.8-dB for nonlinearity compensation across all channels.
An Update on the Queen Isabella Causeway Cathodic Protection Project (2004)

Abstract About five years ago, four different cathodic protection (CP) systems were installed and evaluated in the reinforced concrete tie beams and footings of four bents on the Queen Isabella Causeway. This causeway links South Padre Island to the mainland of Texas. The CP systems included three impressed current systems; sprayed zinc, sprayed titanium, and titanium mesh with overlay as well as a sacrificial system; sprayed zinc. About a year later, another sacrificial CP system, thermally sprayed Aluminum-Zinc-Indium, was also installed and evaluated. This paper is an update on the performance of those systems.
Chemical Aspects of Direct Coagulation Casting of Alumina Suspensions (2004)

This work presents a detailed description of urea decomposition during direct coagulation processing of alumina suspensions. We report on the chemical equilibria involved in the decomposition of urea in an aqueous environment with and without alumina particles. The model uses the logarithm of the concentrations as variables to ensure fast convergence and nonnegativity of the solutions, and is able to give a semiquantitative description of the experimentally observed development of pH and ionic strength (specific conductivity) during the decomposition of urea in a 30 vol% solid loading alumina suspension. Assuming local equilibrium, and a homogeneous distribution of the catalyst urease and the evolving educts, the results show an increasing solubility of CO 2 with increasing pH. As a consequence the production of gaseous CO 2 during the urea decomposition (direct coagulation casting (DCC) process), shifting the pH from 4 to 9 occurs only when a strong buffer is present at low and medium pH. This is advantageous for the preparation of defect‐poor ceramic green bodies using this internal gellation reaction in the DCC process.
I-domain-containing integrins serve as pilus receptors for Neisseria gonorrhoeae adherence to human epithelial cells (2005)

Two pilus receptors are identified for the pathogenic Neisseria, CD46 and complement receptor 3. An intimate association between the asialoglycoprotein receptor and gonococcal lipooligosaccharide mediates invasion of primary, male urethral epithelial cells (UECs); however, studies to identify pilus receptors on these cells have not been performed. Based on our previous studies we reasoned that the I-domain-containing (IDC), alpha(1)- and alpha(2)-integrins might serve as pilus receptors on UECs and on urethral tissue. Confocal microscopy revealed colocalization of pilus with alpha(1) and alpha(2) integrins on UECs and tissue. We found that recombinant I-domain and antibodies directed against the alpha(1)- and alpha(2)-integrins inhibited gonococcal association with UECs and with immortal cell lines of variable origin. Gonococcus-integrin colocalization occurred at early time points post infection, but this interaction dissociated with extended infection. Similarly, Western Blot analyses revealed that gonococcal pilin coimmunoprecipitates with alpha(1)- and alpha(2)-integrins. However, studies performed in parallel and that were designed to capture CD46-pilus immune complexes indicated that a CD46-pilus interaction did not occur. Collectively, these data suggest that while CD46 might be able to bind gonococcal pilus, IDC integrins are preferentially used as the initial docking site for gonococci on UECs, on urethral tissue and on some immortal cell lines.