gebhart/patrepeval huggingface dataset:
Low-Impact Current-Based Distributed Monitoring System for Medium Voltage Networks (2021)

Distribution networks are currently subject to a huge revolution in terms of assets being installed. In particular, the massive spread of renewable energy sources has drastically changed the way of approaching the grid. For example, renewables affected (i) the production of the legacy power plants, (ii) the quality of the supplied energy, decreasing it, (iii) the fault detection and location, etc. To mitigate the significant drawbacks of the renewables’ presence, several intelligent electronic devices have been (and are being) developed and installed among the grid. The aim is to increase grid monitoring and knowledge of its status. However, considering the significant number of nodes of the distribution network, compared to the transmission one, the process of installing new equipment is not effortless and is also quite expensive. This work aims at emphasizing a new concept of distributed monitoring systems, based on the phasor measurement unit’s current measurements, and a controlling algorithm to exploit it. The idea underneath the work is to avoid the out-of-service time needed and the costs associated with the installation of voltage sensors. Therefore, this paper describes an algorithm that exploits measurements from existing equipment and current measurements from PMUs to obtain information on the load and the node voltages. The algorithm is then tested on simulated power networks of increasing complexity and verified with an uncertainty evaluation. The results obtained from the simulation confirm the applicability and effectiveness of the algorithm and the benefits of a current-based monitoring system.
High-frequency link parallel resonant convertor with fourth-order commutation network (1991)

A technique of steady-state analysis for the fourth-order parallel resonant convertor circuit is proposed. The method makes use of the two-dimensional state-plane diagram that has been used successfully to analyse resonant convertors of lower order. Our theoretical results are verified by computer simulations.
CREATIVITY IN ADULTHOOD AND OLD AGE: AN EXPLORATORY STUDY (1982)

The purpose of this study was to explore the creative process and creative products across the adult life span. The subjects were 61 women, ages 20 to 83 years, who were comparable in intelligence, education, and interest in writing. They completed a creative writing project and took three standardized creativity tests and two intelligence subtests. Both quantitative and qualitative differences were found favoring young adults. Predictive but not construct validity was demonstrated for the creativity tests with this population of young and old adults. Both methodological constraints and the ecological validity of these measures of creativity are discussed.
Ultrafast 4D Doppler Imaging of the Rat Brain with a Large Aperture Row Column Addressed Probe (2018)

4D ultrafast imaging has been recently introduced to provide new anatomical, mechanical and functional information. It relies on 2-D matrix array to image the medium at high volume rate and quantify blood flow information. However, this approach requires high channel count electronics (NxN) to drive those probes. An alternative to reduce the density of elements and maintain a decent image at very high volume rate was shown using the Row and Column Addressed (RCA) approach with Orthogonal Plane Wave (OPW) compounding strategy. Furthermore, the RCA configuration presents the advantage of keeping a large surface by reducing the count of channel by a factor N/2. In this study, we designed and built a large 15 MHz 256 channels (128+128) probe dedicated to neurovascular imaging and connected to a 256 channels research electronics. Using OPW image strategy, 4D ultrafast Power Doppler of whole rat brain is performed in vivo with a 23dB dynamic range at 125 Hz on whole brain.
Alterations in Energy Metabolism of Hypertrophied Rat Cardiomyocytes (1995)

Alterations in energy metabolism, reduced fatty acid oxidation, and cardiac carnitine content have been implicated in the evolution from compensated to decompensated cardiac hypertrophy. We determined high-energy nucleotide levels in hypertrophied quiescent cardiomyocytes isolated from rat hearts 4 weeks after banding of abdominal aorta. In hypertrophied quiescent cardiomyocytes, a decrease in ATP content (p = 0.03), and ratios of ATP/total adenine nucleotides and of ATP/ADP were observed, together with an increase in ADP. In addition, palmitate, but not glucose oxidation, was markedly reduced in hypertrophied myocytes. In the presence of 25 microM propionyl-L-carnitine (PLC) or L-carnitine (LC), palmitate oxidation was significantly stimulated in hypertrophied myocytes. The ATP/ADP ratio was significantly increased only with PLC. This effect was not due to an enhanced PLC uptake, since total PLC uptake was 50% lower than that of LC. Changes in the energy generating system of quiescent myocytes occur early in pressure overload hypertrophy, and these alterations can be attenuated by PLC.
Generalized Policy Elimination: an efficient algorithm for Nonparametric Contextual Bandits (2020)

International audience
Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes (2012)

Abstract Abstract 3509 Mutations in the isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) genes are present in ∼16% of acute myeloid leukemia, and cause a neomorphic enzyme activity that results in the production of 2-hydroxyglutarate (2HG). Mutational and epigenetic profiling of a large patient cohort of acute myeloid leukemia (AML) has revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and an impaired hematopoietic differentiation. To further investigate the intrinsic effect of 2HG on hematopoietic proliferation and differentiation, we transfected an erythroleukemia cell line (TF-1) with either IDH1 or IDH2 mutant alleles. These cells overexpress the mutant enzyme, have high levels of 2HG, and exhibit GM-CSF independent growth. Consistent with clinical observations, overexpression of the IDH mutant proteins led to hypermethylation of both histones and DNA. These results suggest that mutations in IDH1/2 could lead to epigenetic rewiring of cells that could facilitate the gain of function phenotype. To gain a broader understanding of the biological consequence of the IDH1/2 gain of function mutations we have generated small molecules that are capable of selectively inhibiting IDHm enzymes. Upon compound treatment in vitro, we are able to reverse hypermethylation of both histones and DNA in Idhm expressing cells. These compounds are also suitable for use in vivo and upon compound treatment are able to lower 2HG by &gt;90% in tumor xenograft models. These data suggest that an inhibitor of IDH1/2 mutations could correct the altered gene expression patterns seen in IDH1/2 mutant AML tumors and potentially lead to a profound effect on hematopoietic differentiation, proliferation and tumor growth. Disclosures: Yen: Agios Pharmaceuticals: Employment, Equity Ownership. Wang:Agios Pharmaceuticals: Employment, Equity Ownership. Schalm:Agios Pharmaceuticals: Employment, Equity Ownership. Hansen:Agios Pharmaceuticals: Employment, Equity Ownership. Straley:Agios Pharmaceuticals: Employment. Kernytsky:Agios Pharmaceuticals: Employment, Equity Ownership. Choe:Agios Pharmaceuticals: Employment, Equity Ownership. Liu:Agios Pharmaceuticals: Employment, Equity Ownership. Popovici-Muller:Agios Pharmaceuticals: Employment, Equity Ownership. Travins:Agios pharmaceuticals: Employment, Equity Ownership. Yang:Agios Pharmaceuticals: Employment, Equity Ownership. Silverman:Agios Pharmaceuticals: Employment, Equity Ownership. Gross:Agios Pharmaceuticals: Employment, Equity Ownership. Dang:Agios Pharmaceuticals: Employment, Equity Ownership. Salituro:Agios Pharmaceuticals: Consultancy, Equity Ownership. Saunders:Agios Pharmaceuticals: Consultancy, Equity Ownership. Dorsch:Agios Pharmaceuticals: Employment, Equity Ownership. Agresta:Agios Pharmaceuticals: Employment. Schenkein:Agios Pharmaceuticals: Employment, Equity Ownership. Su:Agios Pharmaceuticals: Employment, Equity Ownership. Biller:Agios Pharmaceuticals: Employment, Equity Ownership.
Cre expression in primary spermatocytes: A tool for genetic engineering of the germ line (1998)

Transgenic mice were generated expressing a testicular Cre recombinase driven by promoter sequences derived from the gene encoding Synaptonemal Complex Protein 1 (Sycp1), expressed at an early stage of the male meiosis (leptotene to zygotene). Recombination at target LoxP sites was examined during germinal differentiation in mice harboring Sycp1-Cre and a second transgene where LoxP sites flank either the beta geo coding region, the Pgk1 promoter, or a tk-neo cassette inserted into the Rxr alpha locus. The LoxP-flanked transgenes were stably maintained in the somatic tissues of the double transgenic animals, as well as in the progeny of the females. Mice born after mating the double-transgenic males with normal females showed extensive deletions of the LoxP-flanked sequences. When the males were hemizygous for the Sycp1-Cre transgene, the deletions were observed even in the fraction of the offspring which had not inherited the Cre gene, thus demonstrating that expression occurred in the male parent during spermatogenesis. The high efficiency of excision at the LoxP sites makes the Sycp1-Cre transgenic males suitable for evaluating the role of defined gene functions in the germinal differentiation process.
Metal‐Carbon Composite Electrodes from Fiber Precursors: II . Electrochemical Characterization of Stainless Steel‐Carbon Structures (1990)

In this study, the capacitances of stainless steel‐carbon composite electrodes in were determined as a function of stainless steel loading, sintering temperature, and sintering time (i.e., 0.1–0.5g of stainless steel fiber/1g of carbon fiber, 1323–1423 K, and 2.5–152 min, respectively). Kinetic parameters were determined for stainless steel sintering and catalytic carbon gasification by weight loss measurements and capacitance changes using ac impedance, single potential step methods, and cyclic voltammetry. Apparent activation energies for carbon gasification and sintering were found to be 80 and 200 kJ/mol, respectively. Measured reaction rates and kinetic parameters were used to verify the importance of stainless steel‐carbon contacts toward overall electrode capacitance and to successfully predict a maximum capacitance of 45.3 F/g on a total electrode weight basis. This capacitance value yields energy densities of ca. 90 kJ/kg of electrode and does not require pressure for good electrical contact as do electrodes prepared from carbon powders. Capacitance and kinetic measurements demonstrate the ability to control conductivity and active surface area by adjusting: stainless steel to carbon loading, sintering temperature, and sintering time.
Measurement and Visualization of Loudspeaker Cone Vibration (2006)

Optical measurement of loudspeaker cone vibration (scanning vibrometry) can also be accomplished by using Laser triangulation technique which is a cost effective alternative to Doppler interferometry. Since triangulation sensors provide primarily displacement advanced signal processing is required to measure the break-up modes up to 20 kHz at sufficient signal to noise ratio. In addition to stroboscopic animation of the radiation pattern a new decomposition technique is presented for the visualization of the measured data. Radial and circular modes can be separated and the total vibration can be split into radiating and non-radiating vibration components. This kind of post-processing reveals critical vibration modes, simplifies the interpretation and gives indications for further improvements.
PPM performance with BWT complexity: a new method for lossless data compression (2002)

This work combines a new fast context-search algorithm with the lossless source coding models of PPM to achieve a lossless data compression algorithm with the linear context-search complexity and memory of BWT and Ziv-Lempel codes and the compression performance of PPM-based algorithms. Both sequential and nonsequential encoding are considered. The proposed algorithm yields an average rate of 2.27 bits per character (bpc) on the Calgary corpus, comparing favorably to the 2.33 and 2.34 bpc of PPM5 and PPM/sup */ and the 2.43 bpc of BW94 but not matching the 2.12 bpc of PPMZ9, which, at the time of this publication, gives the greatest compression of all algorithms reported on the Calgary corpus results page. The proposed algorithm gives an average rate of 2.14 bpc on the Canterbury corpus. The Canterbury corpus Web page gives average rates of 1.99 bpc for PPMZ9, 2.11 bpc for PPM5, 2.15 bpc for PPM7, and 2.23 bpc for BZIP2 (a BWT-based code) on the same data set.
Draft Genome Sequence of Escherichia coli Strain ATCC 23506 (Serovar O10:K5:H4) (2013)

We report the 5.101-Mbp high-quality draft assembly of the Escherichia coli strain ATCC 23506 (serovar O10:K5:H4, also known as NCDC Bi 8337-41) genome. This uropathogenic strain, commonly referred to as E. coli K5, produces N-acetyl heparosan, a glycosaminoglycan-like capsular polysaccharide and precursor to the anticoagulant pharmaceutical heparin. Metabolic reconstruction of this genome will enable the prediction of gene deletions and overexpressions that lead to increased heparosan production.
Lattice thermodynamics for aqueous salt-polymer two-phase systems (1998)

A lattice model is presented to compute salt-induced liquid–liquid phase separation in aqueous polymer solutions. The Gibbs energy of mixing contains an electrostatic contribution given by Pitzer's extension of the Debye–Hückel function, and the extended Flory–Huggins theory that uses empirical functions of temperature and composition as binary interaction parameters. Our Flory–Huggins theory assumes complete dissociation of salt into ions, but it does not distinguish between cation and anion; our theory represents the water–salt–polymer mixture as an incompressible ternary system consisting of water, ion, and polymer. In the extended Flory–Huggins theory, the binary interaction parameter between water and ion, and that between water and polymer, are obtained by correlating the observed activity of water in each of the two relevant binary systems. The electrostatic contribution does not contain adjustable parameters. We show that the electrostatic contribution to the Gibbs energy of mixing is responsible for inducing salt–polymer aqueous two-phase systems. Calculated phase diagrams are compared with experiment for aqueous solutions containing polyethylene glycol and a single salt at room temperature. The efficiency of a salt to form salt–polymer aqueous two-phase systems is discussed in terms of ion valence and the interaction parameter between ion and polymer. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci Inc. J Appl Polym Sci 68: 2007–2017, 1998
Proline-Catalyzed Sequential syn-Mannich and [4 + 1]-Annulation Cascade Reactions To Form Densely Functionalized Pyrrolidines (2015)

A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.
A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes (2017)

The 1 g monofilament and total QOL-DN are effective, low-cost tools for the early detection of DPN in OOI, PD, and T2D adults. The 128 Hz tuning fork and 10 g monofilament may assist DPN screening as a tandem, but not primary, early DPN detection screening tools.
Effect of CoFe dusting layer and annealing on the magnetic properties of sputtered Ta/W/CoFeB/CoFe/MgO layer structures (2019)

We explored the effect of a CoFe wedge inserted as a dusting layer (0.2 nm-0.4 nm thick) at the CoFeB/MgO interface of a sputtered Ta(2 nm)/W(3 nm)/CoFeB(0.9 nm)/MgO(3 nm)/Ta(2 nm) film-a typical structure for spin-orbit torque devices. Films were annealed at temperatures varying between 300 °C and 400 °C in an argon environment. Ferromagnetic resonance studies and vibrating sample magnetometry measurements were carried out to estimate the effective anisotropy field, the Gilbert damping, the saturation magnetization and the dead layer thickness as a function of the CoFe thickness and across several annealing temperatures. While the as-deposited films present only easy-plane anisotropy, a transition along the wedge from in-plane to out-of-plane was observed across several annealing temperatures, with evidence of a spin-reorientation transition separating the two regions.
Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management (2017)

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity with an incidence of 0.1 to 0.2/100 000/y. Compared with the more common subtypes of classical Hodgkin lymphoma, NLPHL is characterized by distinct pathological and clinical features. Histologically, the disease-defining lymphocyte predominant cells consistently express CD20 but lack CD30. Clinically, NLPHL mostly has a rather indolent course, and patients usually are diagnosed in early stages. The prognosis of early-stage NLPHL is excellent, with progression-free survival and overall survival rates exceeding 90% after involved-field radiotherapy (IF-RT) alone (stage IA) or combined modality treatment consisting of a brief chemotherapy with 2 cycles of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy followed by IF-RT (early stages other than stage IA). In contrast, patients with advanced disease at diagnosis tend to relapse either with NLPHL histology or with histological transformation into aggressive B-cell non-Hodgkin lymphoma despite more aggressive first-line treatment with 6 to 8 cycles of multiagent chemotherapy. However, even NLPHL patients with multiple relapses successfully respond to salvage therapy in many cases. Salvage therapies range from single-agent anti-CD20 antibody treatment to high-dose chemotherapy followed by autologous stem cell transplantation. Treatment at disease recurrence should be chosen on the basis of various factors, including histology at relapse, time to relapse, extent of disease at relapse, and prior treatment. Because death among NLPHL patients is more often caused by therapy-related late effects than lymphoma-related complications, optimizing the risk-benefit ratio of treatment by decreasing toxicity whenever possible is the major goal of clinical research in this disease.
Appendix A: Complex Integrals (2008)

This chapter contains sections titled: Definition of Terms Cauchy-Riemann Conditions Complex Integration Problems
Protein kinase A and its role in human neoplasia: the Carney complex paradigm. (2004)

The type 1 alpha regulatory subunit (R1alpha) of cAMP-dependent protein kinase A (PKA) (PRKAR1A) is an important regulator of the serine-threonine kinase activity catalyzed by the PKA holoenzyme. Carney complex (CNC) describes the association 'of spotty skin pigmentation, myxomas, and endocrine overactivity'; CNC is in essence the latest form of multiple endocrine neoplasia to be described and affects the pituitary, thyroid, adrenal and gonadal glands. Primary pigmented nodular adrenocortical disease (PPNAD), a micronodular form of bilateral adrenal hyperplasia that causes a unique, inherited form of Cushing syndrome, is also the most common endocrine manifestation of CNC. CNC and PPNAD are genetically heterogeneous but one of the responsible genes is PRKAR1A, at least for those families that map to 17q22-24 (the chromosomal region that harbors PRKAR1A). CNC and/or PPNAD are the first human diseases to be caused by mutations in one of the subunits of the PKA holoenzyme. Despite the extensive literature on R1alpha and PKA, little is known about their potential involvement in cell cycle regulation, growth and/or proliferation. The presence of inactivating germline mutations and the loss of its wild-type allele in CNC lesions indicated that PRKAR1A could function as a tumor-suppressor gene in these tissues. However, there are conflicting data in the literature about PRKAR1A's role in human neoplasms, cancer cell lines and animal models. In this report, we review briefly the genetics of CNC and focus on the involvement of PRKAR1A in human tumorigenesis in an effort to reconcile the often diametrically opposite reports on R1alpha.
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine (1990)

A significant number of patients with AIDS and AIDS-related complex develop neurological complications. Therefore, it is critical that anti-HIV agents penetrate the blood-brain barrier and suppress viral replication in the brain. In an effort to increase the brain delivery of anti-HIV nucleosides, in vitro and in vivo pharmacokinetics of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine (AzddU, AZDU, or CS-87) and 3'-azido-3'-deoxythymidine (AZT, Zidovudine) have been studied. In vitro studies of the prodrugs (AzddU-DHP and AZT-DHP) in human serum, mouse serum, and mouse brain homogenate indicated that the rates of serum conversion from prodrugs to parent drugs are species dependent: mouse brain homogenate greater than mouse serum greater than human serum. Half-lives in human serum, mouse serum, and mouse brain homogenate are 4.33, 0.56, 0.17 h, respectively, for AzddU and 7.70, 1.40, and 0.18 h, respectively, for AZT. In vivo studies of AzddU-DHP and AZT-DHP showed that the prodrugs have areas under the serum concentration-time curves (AUC) similar to those of the parent drugs. The AUC in serum for AzddU following prodrug administration is 25.79 micrograms h/mL, which is similar to the value of 25.83 micrograms h/mL when AzddU was administered. Analogously, the serum AUCs for AZT when AZT-DHP and AZT were administered are 25.38 and 26.64 micrograms h/mL, respectively. However, the brain AUCs for both AzddU and AZT derived from prodrugs, being 11.43 and 11.28 micrograms h/mL, respectively, are greater than the brain AUCs for AzddU (2.09 micrograms h/mL) and AZT (1.21 micrograms h/mL) when the parent drugs were administered. Thus, the relative brain exposure (re) for AzddU (5.47) and AZT (9.32) indicate a significant increase in exposure to the anti-HIV nucleosides following prodrug administrations. The results of extended half-lives of the synthesized prodrugs in human serum along with the higher re values in vivo warrant studies in larger animals to determine the potential usefulness of the prodrugs in humans.
Sampling Point Selection Scheme for Fractional Sampling-OFDM Receivers on Fast Time-Varying Multipath Channels (2010)

Fractional sampling (FS) and Doppler diversity equalization in OFDM receivers can achieve two types of diversity (path diversity and frequency diversity) simultaneously on time-varying multipath channels. However FS with a higher sampling rate requires the large amount of complexity in demodulation. In this paper, a novel sampling point selection (SPS) scheme with MMSE equalization in FS-OFDM receivers is proposed. On fast time-varying multipath channels, the proposed scheme selects the appropriate samples from the fractionally sampled signals. Through the computer simulation, it is demonstrated that with the proposed scheme, both path diversity gain and Doppler diversity gain can increase as compared to a conventional non-SPS scheme.