gebhart/patrepeval huggingface dataset:
Comparison between desaturation sensing and Rogowski coil current sensing for shortcircuit protection of 1.2 kV, 300 A SiC MOSFET module (2018)

Silicon Carbide (SiC) MOSFET devices have small internal inductance and small on state resistance, resulting in a huge di/dt which will cause the current to rise to a high level very fast during shortcircuit (SC), causing possible destruction of module due to excessive dissipated energy or high overshoot during the turn-off. Therefore, fast and reliable protection circuit is important to detect the SC as fast as possible to minimize the power dissipation in the components during the fault, thus preventing the device from overheating and destructing. Furthermore, soft turn-off is required to avoid high voltage spike during the turn-off of the fault current. This paper compares and evaluates the SC performance of two different protection methods on CREE 1.2 kV, 300 A SiC MOSFET module. The first protection method utilizes desaturation technique (DeSat), while the second method utilizes a Rogowski coil to sense the current through the device. Experimental results are analyzed to determine which protection method behaves better under different operating conditions.
Nomogram Development and External Validation for Predicting the Risk of Lymph Node Metastasis in T1 Colorectal Cancer (2019)

We presented an externally validated new prediction model for LNM risk in T1 CRC patients, guiding decision making in determining whether additional surgery is required after endoscopic resection of T1 CRC.
Correction to “Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase” (2023)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase"Wei ZhuWei ZhuMore by Wei Zhu, Arseniy ButrinArseniy ButrinMore by Arseniy Butrin, Rafael D. MelaniRafael D. MelaniMore by Rafael D. Melani, Peter F. DoubledayPeter F. DoubledayMore by Peter F. Doubledayhttps://orcid.org/0000-0002-1784-1282, Glaucio Monteiro FerreiraGlaucio Monteiro FerreiraMore by Glaucio Monteiro Ferreirahttps://orcid.org/0000-0002-1952-9428, Mauricio T. TavaresMauricio T. TavaresMore by Mauricio T. Tavareshttps://orcid.org/0000-0002-4400-7787, Thahani S. Habeeb MohammadThahani S. Habeeb MohammadMore by Thahani S. Habeeb Mohammadhttps://orcid.org/0000-0002-5827-0922, Brett A. BeaupreBrett A. BeaupreMore by Brett A. Beaupre, Neil L. KelleherNeil L. KelleherMore by Neil L. Kelleherhttps://orcid.org/0000-0002-8815-3372, Graham R. MoranGraham R. MoranMore by Graham R. Moranhttps://orcid.org/0000-0002-6807-1302, Dali Liu*Dali LiuMore by Dali Liuhttps://orcid.org/0000-0002-7587-703X, and Richard B. Silverman*Richard B. SilvermanMore by Richard B. Silvermanhttps://orcid.org/0000-0001-9034-1084Cite this: J. Am. Chem. Soc. 2023, 145, 17, 9895–9896Publication Date (Web):April 19, 2023Publication History Received31 March 2023Published online19 April 2023Published inissue 3 May 2023https://pubs.acs.org/doi/10.1021/jacs.3c03364https://doi.org/10.1021/jacs.3c03364correctionACS PublicationsCopyright © 2023 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1086Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (834 KB) Get e-Alertsclose Get e-Alerts
Supplementary Figure 4 from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8<sup>+</sup> T-cell–Mediated Tumor Control in the Genital Tract (2023)

&lt;p&gt;Comparison of HPV16 E7-specific CD8+ T cells induced by HPV16 E7 long peptide after either intramuscular or intracervicovaginal vaccination&lt;/p&gt;
Die Wiederherstellung des Marktsubjekts (2009)

Großbritannien gilt im Allgemeinen als ein Labor für „Governance“-Experimente\nunter dem Leitbild des „New Public Management“: Outsourcing, die Einrichtung von\nBinnenmärkten im öffentlichen Dienst, Zielvereinbarungen, Controlling. Der veränderte Regierungsstil\nund die neuen Steuerungsmechanismen, die ihn begleiten, waren einst synonym mit\n„Thatcherismus“, wurden aber von New Labour fortgeführt und weiterentwickelt. Die kritischen\nSozialwissenschaften haben zunächst den Hegemoniebegriff von Gramsci aufgegriffen, um diese\nWende zu analysieren. Später kam das von Foucault inspirierte Paradigma der „Gouvernementalität“\nhinzu, das die Mikroebene des Verhaltens und Benehmens betonte. Dieser Artikel folgt\ndieser Perspektive auf die Mikroebene, versucht aber die zentralen Fragen, die diese Experimente\naufgeworfen haben, unter Rückgriff auf Max Webers Konzept der „bürokratischen Revolution“\nund Karl Polanyis Analyse der Herstellung des Marktsubjekts durch eine gleichzeitige Lockerung\nund Straffung der Kontrolle anzugehen. Der Weber-Polanyi-Ansatz kann die Wechselwirkung\nzwischen den Änderungen auf der Mikroebene der Lebensführung und der Mesoebene von Instrumenten,\ndie diese Änderungen herbeiführen sollten, deutlicher machen. Der Artikel stützt sich\nauf empirische Beispiele aus verschiedenen öffentlichen Dienstleistungssektoren, vor allem aus\ndem Bildungs- und Gesundheitssystem. Die Analyse bestätigt die These, dass nicht eine Aushöhlung\ndes Staates der entscheidende Faktor der Transformation ist, sondern die Veränderung seines\nWirkungsbereichs und seiner Instrumente.
Phosphatidylinositol 3-Kinase Confers Resistance to Encephalomyocarditis and Herpes Simplex Virus-Induced Cell Death Through the Activation of Distinct Downstream Effectors (2001)

The Janus kinase/STAT pathway has emerged as the paradigm of IFN-induced protection from viral infections. However, the possible participation of other signaling proteins in this protection is not clearly understood. In this report, we demonstrate that activation of phosphatidylinositol 3-kinase (PI3K) by either serum factors or IFNs blocks cell death induced by encephalomyocarditis virus (EMCV) and HSV. This increased resistance to virus-induced cell death does not involve the activation of the STAT pathway and occurs in the presence of normal viral replication. Interestingly, the cell uses two different PI3K regulated pathways to block EMCV- and HSV-induced cell death. The increased sensitivity of p85alpha(-/-) embryonic fibroblasts to EMCV-induced cell death is specifically corrected by overexpression of an activated allele of Akt/protein kinase B, but not activated mitogen-activated protein kinase extracellular kinase. Conversely, the augmented sensitivity of p85alpha(-/-) cells to HSV-induced cell death was compensated for by expression of an activated form of mitogen-activated protein kinase extracellular kinase, but not by activated Akt/protein kinase B. We conclude from these data that PI3K-activated pathways function in parallel with the Janus kinase/STAT pathway to protect cells from the lethal effects of viruses.
Liposome distribution after intravenous and selective intraarterial infusion in dogs. (1990)

In an effort to improve hepatic uptake of liposomes for drug delivery, empty vesicles were administered by means of selective arterial infusion. Negatively charged, multilamellar liposomes were labeled with technetium-99m and infused into healthy adult dogs. Each dog received 100 mg/m2 of lipid over 10 minutes at 2 mL/min. Liposomes were administered via the common hepatic artery after proximal occlusion of the gastroduodenal artery, via the cranial mesenteric artery, and via the cephalic vein. Distribution (liver, spleen, and lungs) was determined by computer-assisted external imaging techniques. On the average, after arterial infusion, 69.2% of the total activity was located in the liver, 3.6% in the spleen, 3.2% in the lungs, and 3.5% in the general circulation. Following venous injection, 50.7% of the radioactivity was found in the liver, 9.1% in the spleen, 8.6% in the lungs, and 6.7% in the peripheral blood. Once the liposomes entered the systemic circulation, they were cleared at the same rate (half-life beta = 21.5 hours) independent of their route of administration. Increased hepatic liposome uptake should translate into higher local and lower systemic liposomal drug levels.
Mobile Phones as Computing Devices: The Viruses are Coming! (2004)

Understanding existing threats against mobile phones helps us better protect our information and prepare for future dangers. Mobile phones have evolved from their roots as analog walkie-talkies to full-scale Internet-enabled computers. Today, mobile phone handsets are arguably the dominant computer form factor consumers purchase. But having such powerful networked computers leads to a new class of malware: viruses, worms, and trojans specifically designed for the mobile environment. Merely enumerating known attacks doesn't help us understand all possible threats. Instead, we present a taxonomy of attacks against mobile phones that shows known as well as potential attacks.
Formation of Lithium Titanate Hydrate Nanosheets: Insight into a Two-Dimension Growth Mechanism by in Situ Raman (2016)

Orthorhombic lepidocrocite-type lithium titanate hydrates (LTH), as one important member among two-dimensional (2D) materials, have drawn much attention due to their potential applications in nanoelectronics, energy conversion, and energy storage devices. However, only a few efforts have focused on an anisotropic growth mechanism that determines the formation kinetics of LTH and/or even their derivatives. In this context, in situ Raman observation was employed to the isothermal crystallization of LTH nanosheet crystals from amorphous precursor precipitates. During isothermal crystallization, the formation of monolayered LTH nuclei is controlled by oxygen diffusion with an activation energy of 0.72 eV; anisotropic growth along (010) planes induces an interblocking effect among LTH nanosheet crystals, which limits their size up to 50 nm. The nucleation–growth crystallization kinetics of LTH nanosheets were accurately interpreted by the modified Johnson–Mehl–Avrami–Kolmogorov (JMAK) model, which considered their anisotropic 2D growth. Beyond LTH, the present study that combines in situ spectroscopic monitoring with kinetic modeling paves the way toward deeper comprehension and ultimate control of the growth kinetics of 2D titanate materials.
Angular Analysis of $D^0 \to \pi^+\pi^-\mu^+\mu^-$ and $D^0 \to K^+K^-\mu^+\mu^-$ Decays and Search for $CP$ Violation (2022)

International audience
Engineering circuits of human iPSC-derived neurons and rat primary glia (2022)

ABSTRACT Novel in vitro platforms based on human neurons are needed to improve early drug testing and address the stalling drug discovery in neurological disorders. Topologically controlled circuits of human induced pluripotent stem cell (iPSC)-derived neurons have the potential to become such a testing system. In this work, we build in vitro co-cultured circuits of human iPSC-derived neurons and rat primary glial cells using microfabricated polydimethylsiloxane (PDMS) structures on microelectrode arrays (MEAs). Such circuits are created by seeding either dissociated cells or pre-aggregated spheroids at different neuron-to-glia ratios. Furthermore, an antifouling coating is developed to prevent axonal overgrowth in undesired locations of the microstructure. We assess the electrophysiological properties of different types of circuits over more than 50 days, including their stimulation-induced neural activity. Finally, we demonstrate the effect of magnesium chloride on the electrical activity of our iPSC circuits as a proof-of-concept for screening of neuroactive compounds.
ChemInform Abstract: Ring‐Closing Alkyne Metathesis. Stereoselective Synthesis of the Cytotoxic Marine Alkaloid Motuporamine C. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Involvement of Surface‐Bound Radicals in the Oxidation of Toluene Using Supported Au‐Pd Nanoparticles (2012)

All bound up: Au-Pd nanoparticles having a mean particle size of 3-4nm and supported on titania (see figure; scale bar 2nm) exhibit high activity in the selective oxidation of aromatic hydrocarbons using tert-butyl hydroperoxide as an oxidant. The supported nanoparticles stabilize surface-bound radicals. Copyright © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.
Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse (2022)

Neuromorphic computing targets the hardware embodiment of neural network, and device implementation of individual neuron and synapse has attracted considerable attention. The emulation of synaptic plasticity has shown promising results after the advent of memristors. However, neuronal intrinsic plasticity, which involves in learning process through interactions with synaptic plasticity, has been rarely demonstrated. Synaptic and intrinsic plasticity occur concomitantly in learning process, suggesting the need of the simultaneous implementation. Here, we report a neurosynaptic device that mimics synaptic and intrinsic plasticity concomitantly in a single cell. Threshold switch and phase change memory are merged in threshold switch-phase change memory device. Neuronal intrinsic plasticity is demonstrated based on bottom threshold switch layer, which resembles the modulation of firing frequency in biological neuron. Synaptic plasticity is also introduced through the nonvolatile switching of top phase change layer. Intrinsic and synaptic plasticity are simultaneously emulated in a single cell to establish the positive feedback between them. A positive feedback learning loop which mimics the retraining process in biological system is implemented in threshold switch-phase change memory array for accelerated training.
E2 (2015)

By moving network appliance functionality from proprietary hardware to software, Network Function Virtualization promises to bring the advantages of cloud computing to network packet processing. However, the evolution of cloud computing (particularly for data analytics) has greatly benefited from application-independent methods for scaling and placement that achieve high efficiency while relieving programmers of these burdens. NFV has no such general management solutions. In this paper, we present a scalable and application-agnostic scheduling framework for packet processing, and compare its performance to current approaches.
Substitution of Carbazole Modified Fluorenes as π-Extension in Ru(II) Complex-Influence on Performance of Dye-Sensitized Solar Cells (2011)

A new high molar extinction coefficient ruthenium(II) bipyridyl complex “ cis -Ru(4,-bis(9,9-dibutyl-7-(3,6-di-tert-butyl-9H-carbazol-9-yl)-9H-fluoren-2-yl)-2,-bipyridine)(2,-bipyridine-4,-dicarboxylic acid)(NCS) 2 , BPFC ” has been synthesized and characterized by FT-IR, -NMR, and ESI-MASS spectroscopes. The sensitizer showed molar extinction coefficient of M −1 cm −1 , larger as compared to the reference N 719, which showed M −1 cm −1 . The test cells fabricated using BPFC sensitizer employing high performance volatile electrolyte, ( E 01) containing 0.05 M I 2 , 0.1 M LiI, 0.6 M 1,2-dimethyl-3- n -propylimidazolium iodide, 0.5 M 4- tert -butylpyridine in acetonitrile solvent, exhibited solar-to-electric energy conversion efficiency ( η ) of 4.65% (short-circuit current density () = 11.52 mA/cm 2 , open-circuit voltage () = 566 mV, fill factor = 0.72) under Air Mass 1.5 sunlight, lower as compared to the reference N 719 sensitized solar cell, fabricated under similar conditions, which exhibited η -value of 6.5% ( = 14.3 mA/cm 2 , = 640 mV, fill factor = 0.71). UV-Vis measurements conducted on TiO 2 films showed decreased film absorption ratios for BPFC as compared to those of reference N 719. Staining TiO 2 electrodes immediately after sonication of dye solutions enhanced film absorption ratios of BPFC relative to those of N 719. Time-dependent density functional theory (TD-DFT) calculations show higher oscillation strengths for 4,-bis(9,9-dibutyl-7-(3,6-di-tert-butyl-9H-carbazol-9-yl)-9H-fluoren-2-yl)-2,-bipyridine relative to 2,-bipyridine-4,-dicarboxylic acid and increased spectral response for the corresponding BPFC complex.
Supplementary tables from Detection of T790M, the Acquired Resistance <i>EGFR</i> Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses (2023)

&lt;p&gt;Supplementary tables S1-S3. Supplementary Table S1: Institutional Tumor Genotyping Strategies. Supplementary Table S2: T790M Genotype by Modality. Supplementary Table S3: EGFR Primary Mutation Detection.&lt;/p&gt;
Regulation of ROS Production and Vascular Function by Carbon Monoxide (2012)

Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). CO interacts with reduced iron of heme-containing proteins, leading to its involvement in various cellular events via its production of mitochondrial reactive oxygen species (ROS). CO-mediated ROS production initiates intracellular signal events, which regulate the expression of adaptive genes implicated in oxidative stress and functions as signaling molecule for promoting vascular functions, including angiogenesis and mitochondrial biogenesis. Therefore, CO generated either by exogenous delivery or by HO activity can be fundamentally involved in regulating mitochondria-mediated redox cascades for adaptive gene expression and improving blood circulation (i.e., O(2) delivery) via neovascularization, leading to the regulation of mitochondrial energy metabolism. This paper will highlight the biological effects of CO on ROS generation and cellular redox changes involved in mitochondrial metabolism and angiogenesis. Moreover, cellular mechanisms by which CO is exploited for disease prevention and therapeutic applications will also be discussed.
Variable Dynamic Threshold for Jerk Signal for Contact Detection in Industrial Robot without Force Sensor (2013)

This study proposes a variable dynamic threshold for a jerk signal for achieving contact detection in industrial robots. A sensorless force control is useful for application to advanced industrial robots. The external torque of each joint is estimated accurately by using a disturbance observer and by inverse dynamics calculation. However, the phase-lag of the disturbance observer and the dynamic parameter error cause force estimation errors. These errors hamper quick and reliable contact detection in industrial robots. Therefore, this study proposes a useful contact detection approach that uses a variable dynamic threshold for a jerk signal. The proposed variable dynamic threshold reduces contact detection failures caused by force estimation errors during the free motion of a robot. The proposed threshold is suitable for robot motion and improves the speed of contact detection. Numerical simulation results show that the proposed method is valid for parameter variations in an actual industrial robot. In addition, experimental results show that the dynamic threshold is a useful technique even for application to general robot systems. The dynamic threshold is useful for application to any industrial sensorless force control system.
Finite Automata Models for Anomaly Detection (2002)

ISR develops, applies and teaches advanced methodologies of design and analysis to solve complex, hierarchical,
Advancing Optical Imaging for Breast Margin Assessment: An Analysis of Excisional Time, Cautery, and Patent Blue Dye on Underlying Sources of Contrast (2012)

Breast conserving surgery (BCS) is a recommended treatment for breast cancer patients where the goal is to remove the tumor and a surrounding rim of normal tissue. Unfortunately, a high percentage of patients return for additional surgeries to remove all of the cancer. Post-operative pathology is the gold standard for evaluating BCS margins but is limited due to the amount of tissue that can be sampled. Frozen section analysis and touch-preparation cytology have been proposed to address the surgical needs but also have sampling limitations. These issues represent an unmet clinical need for guidance in resecting malignant tissue intra-operatively and for pathological sampling. We have developed a quantitative spectral imaging device to examine margins intra-operatively. The context in which this technology is applied (intra-operative or post-operative setting) is influenced by time after excision and surgical factors including cautery and the presence of patent blue dye (specifically Lymphazurin™, used for sentinel lymph node mapping). Optical endpoints of hemoglobin ([THb]), fat ([β-carotene]), and fibroglandular content via light scattering (<µ(s)'>) measurements were quantified from diffuse reflectance spectra of lumpectomy and mastectomy specimens using a Monte Carlo model. A linear longitudinal mixed-effects model was used to fit the optical endpoints for the cautery and kinetics studies. Monte Carlo simulations and tissue mimicking phantoms were used for the patent blue dye experiments. [THb], [β-carotene], and <µ(s)'> were affected by <3.3% error with <80 µM of patent blue dye. The percent change in [β-carotene], <µ(s)'>, and [β-carotene]/<µ(s)'> was <14% in 30 minutes, while percent change in [THb] was >40%. [β-carotene] and [β-carotene]/<µ(s)'> were the only parameters not affected by cautery. This work demonstrates the importance of understanding the post-excision kinetics of ex-vivo tissue and the presence of cautery and patent blue dye for breast tumor margin assessment, to accurately interpret data and exploit underling sources of contrast.
Table S1 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer (2023)

&lt;p&gt;Table S1. Drug screening results after treatment at 10 ÂµM for 72h&lt;/p&gt;
Millimeter Waves for5G: From Theory To Practice (2016)

This chapter devotes to mmWave technology for 5G, with emphasis on the key requirements for building a 5G mmWave proof-of-concept (PoC) system. It introduces mmWave PoC system building and outlines desirable features of a mmWave PoC system. The chapter presents a case study of the design of a mmWave PoC system with detailed discussion on its hardware and software architecture. While elegant theoretical research is providing the foundation for some of the core technologies for wireless research for 5G, the realization of 5G on hardware with existing technology will pave the way to its deployment within a target time frame. PoC systems provide access to real-world data, interference, environmental challenges and so on. Significant improvements in the commercial off-the-shelf (COTS) platform for software-defined radio (SDR), along with new software tools for designing wireless PoC systems, are redefining the wireless prototyping process and making it more accessible to the broader research community.