gebhart/patrepeval huggingface dataset:
Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4 (2016)

We demonstrate that miR-29c expression is increased in EuE of baboons and women with endometriosis, which might contribute to a compromised progesterone response by diminishing the levels of FKBP4. Resection of DIE is likely to reverse the progesterone resistance associated with endometriosis in women.
An Unusual Diterpene Glycoside from the Nuts of Almond (Prunus amygdalus Batsch) (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Enhanced Telemetry Return by Integrated RF-Optical TT C (2007)

Science return and high bandwidth communications are key issues to support the foreseen endeavours on spaceflights to the Moon and beyond. For a given mass, power consumption and volume, laser communications can offer an increase in TM bandwidth over classical RF technology allowing for a variety of new options, specifically to missions that require very large distances, such as to the Moon and even beyond [1, 6]. On-board raw data processing could then preferably take place on ground, making use of latest technology further developed during the cruise phase of the probe. Enhanced sensing techniques could be used that generate more science data and access during flight could be faster. The paper presents an overview of an integrated RF-optical TT&C transponder concept.
ProgPrompt: Generating Situated Robot Task Plans using Large Language Models (2023)

Task planning can require defining myriad domain knowledge about the world in which a robot needs to act. To ameliorate that effort, large language models (LLMs) can be used to score potential next actions during task planning, and even generate action sequences directly, given an instruction in natural language with no additional domain information. However, such methods either require enumerating all possible next steps for scoring, or generate free-form text that may contain actions not possible on a given robot in its current context. We present a programmatic LLM prompt structure that enables plan generation functional across situated environments, robot capabilities, and tasks. Our key insight is to prompt the LLM with program-like specifications of the available actions and objects in an environment, as well as with example programs that can be executed. We make concrete recommendations about prompt structure and generation constraints through ablation experiments, demonstrate state of the art success rates in VirtualHome household tasks, and deploy our method on a physical robot arm for tabletop tasks. Website at progprompt.github.io
Temperature Dependence of the Chemical Potential in NaxCoO2: Implications for the Large Thermoelectric Power (2007)

We have performed a temperature-dependent photoemission study of a NaxCoO2 (x~0.8) epitaxial thin film prepared by the reactive solid-phase epitaxy method. The chemical potential shift as a function of temperature was derived from the Co 3d peak shift, and revealed a crossover from the degenerate Fermion state at low temperatures to the correlated hopping state of Co3+/Co4+ mixed-valence at high temperatures. This suggests that the large thermoelectric power at high temperatures should be considered in the correlated hopping picture.
Utilization of Small Changes in Serum Creatinine with Clinical Risk Factors to Assess the Risk of AKI in Critically lll Adults (2014)

Critically ill patients at high AKI risk, based on the combination of clinical factors and early creatinine elevation, are significantly more likely to develop severe AKI. As initially hypothesized, the high-risk combination group methodology can be used to identify patients at low risk for severe AKI in whom AKI biomarker testing may be expected to have low yield. The high risk combination group methodology could potentially allow clinicians to optimize biomarker use.
ChemInform Abstract: Broensted Acid‐Catalyzed Intramolecular Nucleophilic Substitution of the Hydroxyl Group in Stereogenic Alcohols with Chirality Transfer. (2015)

Abstract The H 3 PO 2 ‐catalyzed cyclization of enantioenriched γ‐nucleophile functionalized alcohols to saturated 5‐membered O‐, S‐, and N‐heterocycles is presented.
Influences of Size and Amount of Colloidal Template and Droplet Diameter on the Formation of Porous-structured Hyaluronic Acid Particles (2017)

Combination of spray drying and templating method has been reported as one of the best method to produce porous pharmaceutical particles. However, current development reports have shown successful formation of porous particles with improper information on what mechanism occurs during the synthesis process and what process parameters involve the creation of particles with controllable pore structures and morphologies. In this report, influences of spray-drying parameters (i.e., size and amount of colloidal template, and droplet diameter) on porous particle fabrication were investigated. Hyaluronic acid (as a model of pharmaceutical drug host component) and polystyrene spheres (as a model of template) were used. The experimental results showed that the spray-drying parameters strongly influenced the external morphology (i.e., spherical and doughnut-shaped), particle outer diameter (from 300 to 2000 nm), and porous configuration (i.e., number of hole cavities and pore sizes (from 100 to 300 nm)) of particles. To qualitatively explain our synthesis strategies to get porous structure, the proposal of the particle formation mechanism was added.
Functional Genomics of Mycobacterium tuberculosis Using DNA Microarrays (2003)

Completion of the sequence of the entire genome of strain H37Rv was a benchmark for Mycobacterium tuberculosis research (1). This achievement ushers in the era of genome-wide functional and comparative genomics for this organism. At present, the most powerful enabling technology of the postgenomic era is microarray-based hybridization. Microarrays, by whatever means they are fabricated, contain surface-bound representations of each open reading frame (ORF) of a sequenced genome. Thus, they provide a method for parallel sampling of thousands of different genes within a complex pool of nucleic acids. Microarray gene capacity readily accommodates the number of ORFs in the relatively small genomes of bacteria and yeast and, in principle, can accommodate the entire genetic repertoire of complex multicellular animals. Below, we discuss our fabrication and use of an M. tuberculosis microarray, containing representations of each of the identified 3924 ORFs of this organism. We will describe two applications of this method. In the first-microarray-based gene response, i.e., transcript profiling - we ask the question: which genes are selectively expressed under a particular condition of growth, in a particular host compartment or as a result of inhibition of a metabolic or biosynthetic pathway? In the second, comparative genomics, we use a microarray containing the ORFs of one strain or species to identify ORFs deleted or absent from a second strain or species whose genome sequence may not have been determined. In this manner, microarray-based comparative genomics seeks to learn the ORF-by-ORF relatedness of two similar, but nonidentical organisms whose biological differences are under investigation. Examples of each application have been applied to M. tuberculosis (2,3).
Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules (2017)

Correction for 'The medicinal chemist's toolbox for late stage functionalization of drug-like molecules' by Tim Cernak et al., Chem. Soc. Rev., 2016, 45, 546-576.
An ultra-low power all CMOS Si photonic transmitter (2009)

We report the first 400fJ/bit all-CMOS silicon photonic transmitter made of CMOS depletion ring modulator flip-chip integrated with CMOS driver, and demonstrated error-free 5Gbps transmission of over 1.5Pbits of data without closed-loop ring resonance tuning.
Utilization of Energy Stored in the Form of Na+ and K+ Ion Gradients by Bacterial Cells (1983)

The hypothesis that Na+ and K+ gradients have an energy storing function [V. P. Skulachev (1978) FEBS Lett. 87, 171-176] has been tested in experiments with Escherichia coli, the marine bacterium Vibrio harveyi, an extremely halophilic Halobacterium halobium and a fresh-water cyanobacterium Phormidium uncinatum from Lake Baikal living at an extremely low salt concentration. The capability of these microorganisms to maintain delta microH was compared using motility as a delta microH-supported function. It was found that in all cases the gradient of monovalent cations is competent to prolong the period of active motility after other energy sources are exhausted. Maximal prolongation was found in H. halobium, which in a Na+ medium was still motile when light was switched off for 9 h under anaerobic conditions. In V. harveyi the motility was maintained for 1 h, in E. coli for about 10 min and in Ph. uncinatum for about 2 min. Thus the delta microH buffer capacity of the monovalent cation gradient is proportional to the content of these cations in the habitat. It was also found that in Ph. uncinatum only delta pK is effective, whereas in E. coli and V. harveyi both delta pK and delta pNa are. In E. coli when the K+ release is completed and the cells become motionless, motility can be temporarily restored by adding NaCl which initiates an H+ efflux. Under conditions of exhaustion of energy sources, the Na+ and K+ gradient was shown to stabilize potential in H. halobium cells, measured with a tetraphenylphosphonium probe. In H. halobium and E. coli, the anaerobic ATP level was found to stabilize when the Na+ and K+ gradients were present. Addition of N,N'-dicyclohexylcarbodiimide destabilized this level, which indicated that Na+ and K+ gradients could support de novo ATP synthesis. It is concluded that the data obtained are in agreement with the concept of the energy storing by the Na+ and K+ gradients. Other functions of these gradients and the mechanisms of their formation are discussed.
Dedication of This Special Issue of I&EC Research to Professor Donald R. Paul (2010)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTDedication of This Special Issue of I&EC Research to Professor Donald R. PaulDavid T. Allen and Benny D. Freeman*View Author Information Associate Editors, I&EC Research, Department of Chemical Engineering, The University of Texas at Austin* Corresponding author. E-mail: [email protected]Cite this: Ind. Eng. Chem. Res. 2010, 49, 23, 11857–11858Publication Date (Web):November 24, 2010Publication History Published online24 November 2010Published inissue 1 December 2010https://pubs.acs.org/doi/10.1021/ie1021249https://doi.org/10.1021/ie1021249editorialACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views543Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (4 MB) Get e-AlertscloseSUBJECTS:Chemical engineering and industrial chemistry,Polymer science,Quality management Get e-Alerts
Feed System Design (2022)

No AccessInjection Mold Design EngineeringOct 2022Feed System DesignDavid O. KazmerDavid O. KazmerSearch for more papers by this authorhttps://doi.org/10.3139/9781569908921.006SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 175-234Print ISBN: 978-1-56990-891-4eISBN: 978-1-56990-892-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies (2020)

Structural characterization of the HIV-1 Envelope (Env) glycoprotein has facilitated the development of Env probes to isolate HIV-specific monoclonal antibodies (mAbs). However, preclinical studies have largely evaluated these virus-specific mAbs against chimeric viruses, which do not naturally infect non-human primates, in contrast to the unconstrained simian immunodeficiency virus (SIV)mac239 clone. Given the paucity of native-like reagents for the isolation of SIV-specific B cells, we examined a method to isolate SIVmac239-specific mAbs without using Env probes. We first activated virus-specific B cells by inducing viral replication after the infusion of a CD8β-depleting mAb or withdrawal of antiretroviral therapy in SIVmac239-infected rhesus macaques. Following the rise in viremia, we observed 2- to 4-fold increases in the number of SIVmac239 Env-reactive plasmablasts in circulation. We then sorted these activated B cells and obtained 206 paired Ab sequences. After expressing 122 mAbs, we identified 14 Env-specific mAbs. While these Env-specific mAbs bound to both the SIVmac239 SOSIP.664 trimer and to infected primary rhesus CD4<sup>+</sup> T cells, five also neutralized SIVmac316. Unfortunately, none of these mAbs neutralized SIVmac239. Our data show that this method can be used to isolate virus-specific mAbs without antigenic probes by inducing bursts of contemporary replicating viruses <i>in vivo</i>.
ChemInform Abstract: Simple Route to Cyclopentanol Derivatives. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Resolution of fine biological structure including small narcomedusae across a front in the Southern California Bight (2012)

We sampled a front detected by SST gradient, ocean color imagery, and a Spray glider south of San Nicolas Island in the Southern California Bight between 14 and 18 October 2010. We sampled the front with an unusually extensive array of instrumentation, including the Continuous Underway Fish Egg Sampler (CUFES), the undulating In Situ Ichthyoplankton Imaging System (ISIIS) (fitted with temperature, salinity, oxygen, and fluorescence sensors), multifrequency acoustics, a surface pelagic trawl, a bongo net, and a neuston net. We found higher fluorescence and greater cladoceran, decapod, and euphausiid densities in the front, indicating increased primary and secondary production. Mesopelagic fish were most abundant in oceanic waters to the west of the front, market squid were abundant in the front associated with higher krill and decapod densities, and jack mackerel were most common in the front and on the shoreward side of the front. Egg densities peaked to either side of the front, consistent with both offshore (for oceanic squid and mesopelagic fish) and shelf origins (for white croaker and California halibut). We discovered unusually high concentrations of predatory narcomedusae in the surface layer of the frontal zone. Potential ichthyoplankton predators were more abundant either in the front (decapods, euphausiids, and squid) or shoreward of the front (medusae, chaetognaths, and jack mackerel). For pelagic fish like sardine, which can thrive in less productive waters, the safest place to spawn would be offshore because there are fewer potential predators.
AI-1 Influences the Kinase Activity but Not the Phosphatase Activity of LuxN of Vibrio harveyi (2006)

The Gram-negative bacterium Vibrio harveyi produces and responds to three autoinducers, AI-1, AI-2, and CAI-1 to regulate cell density dependent gene expression by a process referred to as quorum sensing. The concentration of the autoinducers is sensed by three cognate hybrid sensor kinases, and information is channeled via the HPt protein LuxU to the response regulator LuxO. Here, a detailed biochemical study on the enzymatic activities of the membrane-integrated hybrid sensor kinase LuxN, the sensor for N-(d-3-hydroxybutanoyl)homoserine lactone (AI-1), is provided. LuxN was heterologously overproduced as the full-length protein in Escherichia coli. LuxN activities were characterized in vitro and are an autophosphorylation activity with an unusually high ATP turnover rate, stable LuxU phosphorylation, and a slow phosphatase activity with LuxU approximately P as substrate. The presence of AI-1 affected the kinase but not the phosphatase activity of LuxN. The influence of AI-1 on the LuxN--> LuxU signaling step was monitored, and in the presence of AI-1, the kinase activity of LuxN, and hence the amount of LuxU approximately P produced, were significantly reduced. Half-maximal inhibition of kinase activity by AI-1 occurred at 20 mum. Together, these results indicate that AI-1 directly interacts with LuxN to down-regulate its autokinase activity and suggest that the key regulatory step of the AI-1 quorum sensing system of Vibrio harveyi is AI-1-mediated repression of the LuxN kinase activity.
Strain engineering in nanoscale CMOS FinFETs and methods to optimize R<inf>S/D</inf> (2010)

For the first time, we demonstrate stressor contact etch stop liner (sCESL) modulation of parasitics/external resistance in nonplanar devices. We report 17% saturation drive current enhancement in underlap doped cMOS FinFETs attributed to simultaneous lowering of R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/D</sub> via biaxial S/D stress and μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> increase via effective uniaxial channel stress. Our observations imply that biaxial strain engineering for reduction of R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/D</sub> offers a significant opportunity to realize non-planar CMOSFET performance metrics for the 22nm node and beyond.
1,5-Induction in Reactions between (5-Benzylthiopent-2-enyl)stannanes and Aldehydes promoted by Lewis Acids (1995)

The (5-benzylthiopent-2-enyl)stannane 3 after transmetallation with tin(IV) bromide or chloride generates an intermediate allyltin trihalide which reacts with aldehydes with useful levels of 1,5-asymmetric induction.
HLS-based FPGA Acceleration of Light Propagation Simulation in Turbid Media (2018)

Several clinical applications rely on understanding light transport in heterogeneous biological tissues. Researchers usually resort to Monte-Carlo (MC) simulations to model the problem accurately. However, MC simulations require acceleration for better turnaround time, and this motivates the use of Field-Programmable Gate Arrays (FPGAs) to accelerate the algorithm. Nevertheless, the long cycle of developing and verifying FPGA designs makes it challenging to model realistic tissues accurately and smoothly. To this end, we present a complete and highly-optimized MC simulator for light propagation in 3D voxel-based biological tissue representations with floating-point operations using High-Level Synthesis (HLS). We provide practical guidelines in utilizing HLS to create efficient structures that help achieve the desired throughput. We also show where future work is needed to improve HLS. We use Vivado to implement the design on a Xilinx Kintex Ultrascale FPGA running at 150 MHz. With a design time of 1.5 months, experimental results show a 3x speedup against the fastest software simulator published to date.
Controlled 3D nanoparticle deposition by drying of colloidal suspension in designed thin micro-porous architectures (2020)

Nanoparticle deposition by drying of colloidal suspension in thin micro-porous architectures has attracted a lot of attention in scientific research as well as industrial applications. However, the underlying mechanisms of such three-dimensional (3D) deposition are not yet fully revealed due to the complexity of the co-occurring processes of two-phase fluid flows, phase change and mass transport. Consequently, the control of 3D nanoparticle deposition remains a challenge. We use a combined experimental and numerical approach to achieve controlled 3D nanoparticle deposition by drying of colloidal suspension in two pillar-based thin micro-porous architectures. By the design of pillar layout, rectangular-spiral and circular-spiral deposition configurations are obtained globally. By varying the surface wettability, vertically symmetric and sloped nanoparticle depositions can be achieved locally. While the numerical modeling reveals the mechanisms of liquid internal flow, as well as the impact of local drying rate on nanoparticle transport, accumulation and final deposition, the experimental results of deposition configurations validate the controlling strategies. This combined experimental and numerical work provides a framework to achieve desired 3D nanoparticle deposition in thin micro-porous architectures, with a thorough understanding of the underlying mechanisms of two-phase fluid flows, phase change and mass transport.
Abstract TP434: Mouse Bilateral Carotid Artery Stenosis Leads to Unexpected Early Changes in Blood-Brain Barrier Integrity (2017)

Bilateral carotid artery stenosis (BCAS) is one experimental model of vascular dementia that is thought to preferentially impact brain white matter. Indeed, it is generally accepted that hippocampal and cortical pathology is not observed prior to 30 days post-injury. Since changes in the blood-brain barrier (BBB) permeability are known to precede more overt brain pathology in a variety of diseases, we hypothesized that BBB changes could occur earlier after BCAS in the hippocampus, striatum and cortex and be a precursor of longer term pathology in these regions. In our study, 3 month old male C57/Bl6 mice underwent BCAS with 0.18 mm coils or sham surgery control and changes in BBB were analyzed by collagen IV (vascular basement membrane component), claudin-5 and occludin (tight junction proteins), Evan’s blue (permeability marker), and Ki-67 (marker of cell proliferation) immunohistochemistry, protein and RNA expression levels after 3, 7, 14, or 21 days. Surprisingly, significant changes in markers of cerebrovascular integrity were detected within 7 days compared to sham animals, not only in the striatum but also in the hippocampus. Increased astrocyte and microglia activation was also observed in these regions and TUNEL staining also indicates cell death in the hippocampus within 7 days. While few changes were observed in the cortex, some of the animals did experience cortical ischemic infarcts within 14 days. In conclusion, this study demonstrates for the first time that changes in the BBB occur shortly after BCAS in multiple regions throughout the brain and suggests that such changes might underlie the gradual development of BCAS non-white matter pathology.