gebhart/patrepeval huggingface dataset:
Field-enhancing photonic devices utilizing waveguide coupling and plasmonics - a selection rule for optimization-based design (2018)

This paper describes a systematic design study of periodic gold-nanostrip arrays placed on a thin film aimed at enhancing the electric field inside the film when irradiated by light. Based on the study, a "selection rule" is proposed, which provides optimization-based design methods with an a priori choice between field-enhancement dominated by coupling to guided modes, by plasmonic near-field enhancement or by a mix hereof. An appropriate choice of wavelength and grating period is shown to selectively suppress or include waveguiding effects for the optimized designs. The validity of the selection rule is demonstrated through a numerical topology optimization study in which gold nanostrips are optimized for electric-field enhancement in an erbium-doped TiO<sub>2</sub> thin film, targeting increased spectral upconversion in the erbium ions. The obtained designs exhibit waveguide excitation within the predicted intervals and, for light polarized perpendicularly to the strips, plasmonic response outside.
Fast Recognition of Human Actions Using Autocorrelation Sequence (2018)

Recent state-of-the-art systems for human action recognition are computationally intensive due to the use of full-length videos and complex network structures. This study aims to develop sampling strategies as well as simple network structure to boost inference time of recognition. Especially, auto-correlation sequence, which shows the similarity between a video and a lagged version of itself, is adopted to extract the most essential segment of the video without information loss. The proposed method considerably reduces inference time while keeping comparable recognition accuracy.
ChemInform Abstract: First Synthesis of Subelliptenone F, an Inhibitor of Topoisomerase II. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SPAN: Improved Current Steering on the Advanced Bionics CII and HiRes90K System (2010)

(2010). SPAN: Improved Current Steering on the Advanced Bionics CII and HiRes90K System. Cochlear Implants International: Vol. 11, Proceedings of the 9th European Symposium on Paediatric Cochlear Implantation, Warsaw, 2009, pp. 465-468.
Gliding and saccadic gaze gesture recognition in real time (2012)

Eye movements can be consciously controlled by humans to the extent of performing sequences of predefined movement patterns, or 'gaze gestures'. Gaze gestures can be tracked noninvasively employing a video-based eye tracking system. Gaze gestures hold the potential to become an emerging input paradigm in the context of human-computer interaction (HCI) as low-cost eye trackers become more ubiquitous. The viability of gaze gestures as an innovative way to control a computer rests on how easily they can be assimilated by potential users and also on the ability of machine learning algorithms to discriminate in real time intentional gaze gestures from typical gaze activity performed during standard interaction with electronic devices. In this work, through a set of experiments and user studies, we evaluate the performance of two different gaze gestures modalities, gliding gaze gestures and saccadic gaze gestures, and their corresponding real-time recognition algorithms, Hierarchical Temporal Memory networks and the Needleman-Wunsch algorithm for sequence alignment. Our results show that a specific combination of gaze gesture modality, namely saccadic gaze gestures, and recognition algorithm, Needleman-Wunsch, allows for reliable usage of intentional gaze gestures to interact with a computer with accuracy rates higher than 95% and completion speeds of around 1.5 to 2.5 seconds per gesture. The optimal gaze gesture modality and recognition algorithm do not interfere with otherwise standard human-computer gaze interaction, generating very few false positives during real time recognition and positive feedback from the users. These encouraging results and the low cost eye tracking equipment used, open up a new HCI paradigm for the fields of accessibility and interaction with smartphones, tablets, projected displays and traditional desktop computers.
Fundamental voice frequence during normal and abnormal growth, and after androgen treatment. (1978)

A simple treatment was shown to be suitable for clinical measurement of fundamental voice frequency. Basal frequency (SFF) and lowest frequency (LF) were determined in 374 normal subjects aged 6 years to adulthood. SFF fell between ages 8 and 10 years in boys (from 259 to 247 Hz), but not in girls (253 Hz). LF fell between ages 6 and 10 years in boys (from 234 to 203 Hz) and girls (from 230 to 218 Hz), and a sex difference appeared. In puberty, parallel to pubic hair (PH) development, a gradual fall of SFF and LF occurred in both boys (to 100 and 90 Hz, respectively) and girls (to 213 and 180 Hz). As a group, young hypopituitary children and girls with Turner9s syndrome had a high SFF, and prepubertal boys with delayed maturation a low SFF. In some children with prenatal growth failure, SFF was abnormally high. The girls with Turner9s syndrome exhibited a high, though individually variable, sensitivity of voice to androgen; their voices became lower before the appearance of any other masculinising effects. The instrument is useful for characterisation of growth failure syndromes and stages of puberty. It is particularly recommended for monitoring an undesirable effect on the voice during androgen treatment.
Eradication of Tumors in Pre-Clinical Models of Multiple Myeloma by Anti-CS1 Monoclonal Antibody HuLuc63: Mechanism of Action Studies. (2006)

Abstract Introduction: We have recently shown that CS1 (CD2 subset 1, CRACC, SLAMF7), a cell surface glycoprotein of the CD2 family, is uniformly expressed on myeloma cells from multiple myeloma (MM) patients. Based on its high expression in MM and limited expression in normal cells, we propose CS1 as a novel and specific antibody target for the treatment of MM. Methods: A panel of monoclonal anti-CS1 antibodies (mAbs) was generated to identify a potential therapeutic candidate. MAb clones MuLuc63 and MuLuc90 were selected for testing in CS1 positive MM xenograft models in vivo in severe combined immunodeficient mice. HuLuc63, a humanized IgG1 version of MuLuc63, was generated as the potential therapeutic candidate for the treatment of MM. HuLuc63 and Fc-modified versions of HuLuc63 were tested for anti-tumor activity in mouse models vivo. In vitro antibody-dependent cellular cytotoxicity (ADCC) assays were performed to define the potential mechanism of action for HuLuc63. Results: Both MuLuc63 and MuLuc90 exhibited significant in vivo anti-tumor activity compared to isotype control antibodies in the L363 MM xenograft model. MuLuc63 was significantly more potent, resulting in rapid tumor eradication in most of the animals for the length of the study (~4 months). Based on these results, MuLuc63 was humanized to generate HuLuc63, which exhibited similar affinity for CS1 when compared to the mouse parent antibody. In two different MM xenograft models, L363 and OPM2, HuLuc63 exhibited significant anti-tumor activity resulting in tumor eradication in a high proportion of animals. To investigate the mechanism of action, two modified versions of HuLuc63 were tested in xenograft models. One version, HuLuc63-Ala,Ala, exhibits a mutation in the Fc region that decreases the ability to interact with the Fc receptor on natural killer (NK) cells. The second version, HuLuc63-LF, exhibits low levels of fucosylation in the Fc region that would result in increased binding to the Fc receptor. Compared to HuLuc63, the LF version exhibited significantly better in vivo anti-tumor activity towards, while the Ala,Ala mutant exhibited no anti-tumor activity. These data indicate that the Fc region of HuLuc63 is critical for its anti-tumor activity, and suggest ADCC as a possible mechanism of action. In vitro, HuLuc63 exhibits substantial ADCC towards L363 and OPM2 cells. The activity was dose-dependent, with increasing cytotoxicity being observed with concentrations ranging from 0.01μg/mL to10 μg/mL. Conclusions: These pre-clinical data support HuLuc63 as a new therapeutic for the treatment of MM and suggest that ADCC is part of the mechanism of action. HuLuc63 will be entering a phase I clinical study for multiple myeloma.
Erratum: Optimized Interactions for Targeted Self-Assembly: Application to a Honeycomb Lattice [Phys. Rev. Lett.95, 228301 (2005)] (2006)

Received 17 October 2006DOI:https://doi.org/10.1103/PhysRevLett.97.239901©2006 American Physical Society
Natural Frequency Shift in a Centrifugal Compressor Impeller for High-Density Gas Applications (2011)

In designing an impeller for centrifugal compressors, it is important to predict the natural frequencies accurately in order to avoid resonance caused by pressure fluctuations due to rotorstator interaction. However, the natural frequencies of an impeller change under high-density fluid conditions. The natural frequencies of pump impellers are lower in water than in air because of the added mass effect of water, and in high-pressure compressors the mass density of the discharge gas can be about one-third that of water. So to predict the natural frequencies of centrifugal compressor impellers, the influence of the gas must be considered. We previously found in the non-rotating case that some natural frequencies of an impeller decreased under high-density gas conditions but others increased and that the increase of natural frequencies is caused by fluid-structure interaction, not only the added mass effect but also effect of the stiffness of the gas. In order to develop a method for predicting natural frequencies of centrifugal compressor impellers for high-density gas applications, this paper presents experimental results obtained using a variable-speed centrifugal compressor with vaned diffusers. The maximum mass density of its discharge gas is approximately 300 kg/m3. The vibration stress on an impeller when the compressor was speeding up or slowing down was measured by strain gages, and the natural frequencies were determined by resonance frequencies. The results indicate that for high-density centrifugal compressors, some natural frequencies of an impeller increased in high-density gas. To predict this behavior, we developed a calculation method based on the theoretical analysis of a rotating disc. Its predictions are in good agreement with experimental results.
Low-power photonic links: Breaking the picojoule-per-bit barrier (2010)

We review the potential benefits and challenges for achieving optical-interconnects to the chip via the native integration of silicon photonics components with VLSI electronics; and review the "macrochip" a collection of contiguous silicon chips enabled by optical proximity communication. We summarize recent progress towards achieving low-power photonic links for the macrochip.
A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer’s Disease (2020)

Numerous clinical trials of drug candidates for Alzheimer's disease (AD) have failed, and computational drug repositioning approaches using omics data have been proposed as effective alternative approaches to the discovery of drug candidates. However, little multi-omics data is available for AD, due to limited availability of brain tissues. Even if omics data exist, systematic drug repurposing study for AD has suffered from lack of big data, insufficient clinical information, and difficulty in data integration on account of sample heterogeneity derived from poor diagnosis or shortage of qualified post-mortem tissue. In this study, we developed a proteotranscriptomic-based computational drug repositioning method named Drug Repositioning Perturbation Score/Class (DRPS/C) based on inverse associations between disease- and drug-induced gene and protein perturbation patterns, incorporating pharmacogenomic knowledge. We constructed a Drug-induced Gene Perturbation Signature Database (DGPSD) comprised of 61,019 gene signatures perturbed by 1,520 drugs from the Connectivity Map (CMap) and the L1000 CMap. Drugs were classified into three DRPCs (High, Intermediate, and Low) according to DRPSs that were calculated using drug- and disease-induced gene perturbation signatures from DGPSD and The Cancer Genome Atlas (TCGA), respectively. The DRPS/C method was evaluated using the area under the ROC curve, with a prescribed drug list from TCGA as the gold standard. Glioblastoma had the highest AUC. To predict anti-AD drugs, DRPS were calculated using DGPSD and AD-induced gene/protein perturbation signatures generated from RNA-seq, microarray and proteomic datasets in the Synapse database, and the drugs were classified into DRPCs. We predicted 31 potential anti-AD drug candidates commonly belonged to high DRPCs of transcriptomic and proteomic signatures. Of these, four drugs classified into the nervous system group of Anatomical Therapeutic Chemical (ATC) system are voltage-gated sodium channel blockers (bupivacaine, topiramate) and monamine oxidase inhibitors (selegiline, iproniazid), and their mechanism of action was inferred from a potential anti-AD drug perspective. Our approach suggests a shortcut to discover new efficacy of drugs for AD.
Voltage induced magnetostrictive switching of nanomagnets: Strain assisted strain transfer torque random access memory (2014)

A spintronic device, called the “strain assisted spin transfer torque (STT) random access memory (RAM),” is proposed by combining the magnetostriction effect and the spin transfer torque effect which can result in a dramatic improvement in the energy dissipation relative to a conventional STT-RAM. Magnetization switching in the device which is a piezoelectric-ferromagnetic heterostructure via the combined magnetostriction and STT effect is simulated by solving the Landau-Lifshitz-Gilbert equation incorporating the influence of thermal noise. The simulations show that, in such a device, each of these two mechanisms (magnetostriction and spin transfer torque) provides in a 90° rotation of the magnetization leading a deterministic 180° switching with a critical current significantly smaller than that required for spin torque alone. Such a scheme is an attractive option for writing magnetic RAM cells.
Effects of cyclic pulsed operation on the coil performance in the Nb/sub 3/Sn Demo poloidal coil (DPC-EX) (1994)

The effect of cyclic pulsed operation on the coil performance was studied from the electrical and mechanical points of view in the second experiment of the Nb/sub 3/Sn Demo Poloidal Coil (DPC-EX). Current sharing temperatures, ac losses, displacements, and strains were measured before and after cyclic pulsed operation, which consisted of about 350 cycles. No degradation of the electrical and mechanical performance of the DPC-EX was observed in the range of these cycles.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Construction of an Efficient Biologically Contained Pseudomonas putida Strain and Its Survival in Outdoor Assays (1998)

Active biological containment systems consist of two components, a killing element designed to induce cell death and a control element which modulates the expression of the killing function. We constructed a mini-Tn5 transposon bearing a fusion of the Plac promoter to the gef killing gene and a fusion of the Pm promoter to the lacI gene plus the positive regulator of the Pm promoter, the xylS gene. This mini-Tn5 transposon was transferred to the chromosome of Pseudomonas putida CMC4, and in culture this strain survived in the presence of 3-methylbenzoate (an XylS effector) and committed suicide in the absence of this aromatic compound. The rate of killing escape was on the order of 10(-8) per cell and per generation. This contained strain and an uncontained control strain were used in outdoor tests performed in the spring-summer and autumn-winter periods to determine their survival in planted and unplanted soils with and without 3-methylbenzoate. In unplanted soils the numbers of both the contained strain and the uncontained strain per gram of soil tended to decrease, but the numbers of the contained strain decreased faster in soils without 3-methylbenzoate. The decrease in the number of CFU per gram of soil was faster in the spring-summer period than in the autumn-winter period. In planted soils survival in the rhizosphere and survival in bulk soil were studied. In the rhizosphere the uncontained control strain tended to become established at levels on the order of 10(5) to 10(6) CFU/g of soil regardless of the presence of 3-methylbenzoate. In the bulk soil the numbers of bacterial cells were 2 to 3 orders of magnitude lower. In planted soils the contained strain tended to disappear, but this tendency was more pronounced in the absence of 3-methylbenzoate and occurred faster in the summer assay than in the winter assay. We found no evidence of dispersal of the test strains outside the experimental plots.
Book reviews (1954)

A SURVEY OF VERB FORMS IN THE EASTERN UNITED STATES, STUDIES IN AMERICAN ENGLISH 2. By Bagby E. Atwood. Ann Arbor: University of Michigan Press, 1953; pp. vi + 53. $2.50. RADIO ENGLISH. By Florence Felton French, William B. Levenson, and Vera Cober Rockwell. New York: McGraw‐Hill Book Company, Inc., 1952; pp. xiii + 368. $3.60. DISCUSSION AND DEBATE. By Henry Ewbank and Jeffrey Auer. New York: Appleton‐Century‐Crofts, Inc., 1951; pp. ix‐492. $3.75. PROBLEMS OF OPERA PRODUCTION. By Walter R. Volbach. Fort Worth: Texas Christian University Press, 1953; pp. xii + 196. $4.00. THE NATURE OF ROMAN COMEDY. By George E. Duckworth. Princeton: Princeton University Press, 1952; pp. xiii + 501. $7.50. DIAGNOSTIC MANUAL IN SPEECH CORRECTION. By Wendell Johnson, Frederic L. Darley, and D. C. Spriestersbach, New York: Harper and Brothers, 1952; pp. viii + 221. $2.50. A CASE BOOK IN SPEECH THERAPY. By C. Van Riper. New York: Prentice‐Hall, 1953; pp. 141. $2.75. POETRY, RELIGION AND THE SPIRITUAL LIFE. By George F. Thomas. Houston: The Elzevier Press, 1951; pp. ix + 113. $2.00. EXCURSIONS INTO PRACTICAL COMPOSITION. Made available by Garland Greever. New York: Appleton‐Century‐Crofts, 1952. pp. xvi + 377. $2.50. INTERPRETATIVE SPEECH. By Lionel Crocker. New York: Prentice‐Hall, Inc., 1952; pp. viii + 358. $4.25.
Laser program annual report, 1980 (1981)

Volume 3 is comprised of three sections, beginning with Section 8 on Advanced Lasers. Both theoretical and experimental research and development activities on advanced laser systems are presented here. Section 9 contains the results of studies in areas of energy and military applications, including those relating to electrical energy production by inertial confinement fusion systems. Finally, Section 10 presents results from selected activities in the Advanced Isotope Separation Program.
Time‐Resolved Infrared (TRIR) Studies of Organic Reactive Intermediates (2006)

This chapter contains sections titled: Introduction Instrumental Approaches to TRIR Spectroscopy Applications of TRIR Spectroscopy to the Study of Organic Reactive Intermediates Conclusions and Outlook Acknowledgment Suggested Reading References
Trillium™ Biopassive Surface: A New Biocompatible Treatment for Extracorporeal Circulation Circuits (2000)

139 patients undergoing cardiac surgery were included in a prospective, randomized trial. Patients were randomly allocated to receive cardiopulmonary bypass (CPB) with Trillium Biopassive Surface (TBS Group) coated oxygenators or conventional circuits (control group). 112 patients were studied with respect to postoperative biochemical profile; a subgroup of 27 patients was studied with respect to perioperative complement (C3a) activation. Patients in the TBS group demonstrated a significantly lower white blood cell count at the end of the operation (p=0.036) and a significantly higher platelet count the day after the operation (p=0.023) when compared to the control group. C3a was significantly higher (p=0.02) in the TBS group after 30 minutes of CPB, but the C3a increase after protamine administration was significantly less pronounced in the TBS group vs. the control group. Further studies involving platelet and leukocyte activation are required to better elucidate the action of this new coating in the setting of routine CPB.
Adjusting Implant Size and Position Can Improve Internal Rotation After Reverse Total Shoulder Arthroplasty in a Three-dimensional Computational Model (2020)

Abstract Background Efforts during reverse total shoulder arthroplasty (RSA) have typically focused on maximizing ROM in elevation and external rotation and avoiding scapular notching. Improving internal rotation (IR) is often overlooked, despite its importance for functional outcomes in terms of patient self-care and hygiene. Although determinants of IR are multifactorial, it is unable to surpass limits of bony impingement of the implant. Identifying implant configurations that can reduce bony impingement in a computer model will help surgeons during preoperative planning and also direct implant design and clinical research going forward. Questions/purposes In a CT-modeling study, we asked: What reverse total shoulder arthroplasty implant position improves the range of impingement free internal rotation without compromising other motions (external rotation and extension)? Methods CT images stored in a deidentified teaching database from 25 consecutive patients with Walch A1 glenoids underwent three-dimensional templating for RSA. Each template used the same implant and configuration, which consisted of an onlay humeral design and a 36-mm standard glenosphere. The resulting constructs were virtually taken through ROM until bony impingement was found. Variations were made in the RSA parameters of baseplate lateralization, glenosphere size, glenosphere overhang, humeral version, and humeral neck-shaft angle. Simulated ROM was repeated after each parameter was changed individually and then again after combining multiple changes into a single configuration. The impingement-free IR was calculated and compared between groups. We also evaluated the effect on other ROM including external rotation and extension to ensure that configurations with improvements in IR were not associated with losses in other areas. Results Combining lateralization, inferiorization, varus neck-shaft angle, increased glenosphere size, and increased humeral anteversion resulted in a greater improvement in internal rotation than any single parameter change did (median baseline IR: 85° [interquartile range 73° to 90°]; combined changes: 119° [IQR 113° to 121°], median difference: 37° [IQR 32° to 43°]; p &lt; 0.001). Conclusion Increased glenosphere overhang, varus neck-shaft angle, and humeral anteversion improved internal rotation in a computational model, while glenoid lateralization alone did not. Combining these techniques led to the greatest improvement in IR. Clinical Relevance This computer model study showed that various implant changes including inferiorization, varus neck-shaft angle, increased glenosphere size, and increased humeral anteversion can be combined to increase impingement-free IR. Surgeons can employ these currently available implant configurations to improve IR when planning and performing RSA. These findings support the need for further clinical studies validating the effect of implant configuration on resultant IR.