gebhart/patrepeval huggingface dataset:
Synthesis of narrow‐polydispersity degradable dendronized aliphatic polyesters (2004)

Abstract The divergent dendronization of an ϵ‐caprolactone‐based polymer has been performed to provide access to dendronized polymers with sufficient biocompatibility and degradability for use as drug‐delivery scaffolds. The synthesis was performed through the tin(II) 2‐ethylhexanoate‐catalyzed polymerization of a γ‐functionalized ϵ‐caprolactone monomer, followed by the divergent growth of pendant polyester dendrons at each repeat unit. The resulting dendronized polymers were obtained up to the fourth generation with molecular weights as high as 80,000 Da and with polydispersities between 1.11 and 1.22. The fourth‐generation hydroxyl‐terminated dendronized polymer was degradable under a variety of aqueous conditions. A comparison of the dendronization approach with a procedure involving the ring‐opening polymerization of a second‐generation dendritic macromonomer reveals that the former procedure is best suited for the preparation of this family of dendronized polyesters because it requires shorter reaction times and affords materials with higher degrees of polymerization. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3563–3578, 2004
DeepContext: Context-Encoding Neural Pathways for 3D Holistic Scene Understanding (2017)

3D context has been shown to be extremely important for scene understanding, yet very little research has been done on integrating context information with deep neural network architectures. This paper presents an approach to embed 3D context into the topology of a neural network trained to perform holistic scene understanding. Given a depth image depicting a 3D scene, our network aligns the observed scene with a predefined 3D scene template, and then reasons about the existence and location of each object within the scene template. In doing so, our model recognizes multiple objects in a single forward pass of a 3D convolutional neural network, capturing both global scene and local object information simultaneously. To create training data for this 3D network, we generate partially synthetic depth images which are rendered by replacing real objects with a repository of CAD models of the same object category1. Extensive experiments demonstrate the effectiveness of our algorithm compared to the state of the art.
Low V<inf>T</inf> CMOS using doped Hf-based oxides, TaC-based Metals and Laser-only Anneal (2007)

A gate-first process was used to fabricate CMOS circuits with high performing high-K and metal gate transistors. Symmetric low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> values of plusmn 0.25 V and unstrained I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DSAT</sub> of 1035/500 muA/mum for nMOS/pMOS at I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> =100nA/mum and |V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> |=1.1 V are demonstrated on a single wafer. This was achieved using Hf-based high-k dielectrics with La (nMOS) and Al (pMOS) doping, in combination with a laser-only activation anneal to maintain band-edge EWF and minimal EOT re-growth. The laser-only anneal further results in improved L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</sub> scaling of 15 nm and a 2 Aring T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">INV</sub> reduction over the spike reference.
Topology Control Scheme Providing Throughput Requirement of a Service in Wireless Sensor Networks (2015)

무선 센서 네트워크는 다양한 응용 서비스에 이용이 가능한 네트워크이다. 다양한 응용 서비스에 따라서 서비스에서 요구하는 네트워크 전송량은 매우 다양하다. 특히 무선 센서 네트워크에서는 센서 노드의 에너지 소모를 줄이고 통신 효율성을 높이기 위해서 다양한 토폴로지 제어 방법들이 제시되어 왔다. 이러한 토폴로지 제어 방법들은 대부분 통신의 효율성 측면에서 연구가 되어왔기 때문에 실제 응용 서비스에서 요구되는 데이터 전송량을 만족시키지 못하는 문제점이 있다. 본 논문에서는 이러한 문제를 해결하기 위해서 응용 서비스에서 요구하는 데이터 전송량을 만족시킬 수 있도록 하는 토폴로지 제어 알고리즘을 제시하였다. There are various kinds of applications for wireless sensor network, and each application has difference requirements such as throughput. Topology control is the key issue to minimize energy consumption by solving communication collision and radio interference. However, existing topology control algorithms cannot support application requirement because communication efficiency and network connectivity are the main issues of topology control. In this paper, we propose a topology control algorithm that support throughput requirement of an application.
Role of renal dopamine D1 receptors in natriuresis induced by calcium channel blockers (1994)

The direct tubular natriuretic effect of calcium channel blockers (CCBs) may be due to an interaction between CCBs and a renal tubular dopamine receptor. We therefore studied the effects of two chemically unrelated CCBs, diltiazem and isradipine, infused into the right renal artery of 5% saline-loaded anesthetized rats alone or in the presence of a D1 antagonist, SKF-83742. Isradipine (0.03 microgram.kg-1.min-1) or diltiazem (20 but not 10 micrograms.kg-1.min-1) alone produced an increase in urine flow and an approximate doubling of absolute and fractional sodium excretion, which was not seen in the left kidney or in the control animals (analysis of variance, Scheffé's test, P < 0.05). SKF-83742 alone given systemically or into the right renal artery did not affect these parameters but did block the actions of diltiazem or isradipine. There was no change in mean arterial pressure, renal blood flow, or glomerular filtration rate in any of the experiments. In additional studies, we found that a combined infusion of dopamine (0.1 microgram.kg-1.min-1) and diltiazem (10 micrograms.kg-1.min-1) (doses that by themselves did not alter renal function) produced a twofold or greater increase in urine flow and absolute and fractional sodium excretion; glomerular filtration rate was not significantly changed. Intrarenal arterial CCBs, without a change in renal hemodynamics, produce a natriuresis that is blocked by a D1 antagonist. Concomitant administration of diltiazem and dopamine (each in subeffective doses when used alone) produces a synergistic effect.(ABSTRACT TRUNCATED AT 250 WORDS)
Methyl 2-Amino-4-[1-(tert-butoxycarbonyl)azetidin-3-yl]-1,3-selenazole-5-carboxylate (2021)

Methyl 2-amino-4-[1-(tert-butoxycarbonyl)azetidin-3-yl]-1,3-selenazole-5-carboxylate as a newly functionalized heterocyclic amino acid was obtained via [3+2] cycloaddition. The structure of the novel 1,3-selenazole was unequivocally confirmed by detailed 1H, 13C, 15N, and 77Se NMR spectroscopic experiments, HRMS and elemental analysis.
Ion acceleration and anomalous transport in the near wake of a plasma limiter (1997)

Ion acceleration and anomalous transport were studied experimentally in the near wake region of an electrically floating disk limiter immersed in two different types of collisionless, supersonically flowing, magnetized plasmas: the first initially quiescent, the second initially turbulent. Ion densities and velocity distributions were obtained using a nonperturbing laser induced fluorescence diagnostic. Large-amplitude, low-frequency turbulence was observed at the obstacle edge and in the wake. Rapid ion and electron configuration space transport and ion velocity space transport were observed. Configuration space and velocity space transport were similar for both quiescent and turbulent plasma-obstacle systems, suggesting that plasma-obstacle effects outweigh the effects of initial plasma turbulence levels.
A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis (2015)

Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium and increases muscle force following subtetanic nerve input. In an animal model of myasthenia gravis (MG), single oral doses of tirasemtiv improved muscle force and reduced fatigability. The purpose of this study was to determine the effect of single doses of tirasemtiv on skeletal muscle function and fatigability in patients with generalized MG. Thirty-two patients with acetylcholine receptor-antibody positive MG and muscle weakness received single doses of tirasemtiv (250 mg or 500 mg) or placebo in a double-blind, randomized treatment sequence with each treatment separated by at least 1 week. Outcome measures included the Quantitative MG Score (QMG), MG Composite, Manual Muscle Testing, and forced vital capacity. At 6 h after dosing, tirasemtiv produced dose-related improvements from baseline in the QMG score (slope: -0.49 QMG point per 250 mg; p = 0.02) and in percent predicted forced vital capacity (slope: 2.2% per 250 mg; p = 0.04). QMG improved >3 points in twice as many patients after 500 mg tirasemtiv than after placebo. Both doses of tirasemtiv were well tolerated; there were no premature terminations or serious adverse events. The results of this study suggest that tirasemtiv may improve muscle function in MG and will be used to support further development of tirasemtiv in neuromuscular diseases.
Comparing Photon and Charged Particle Therapy Using DNA Damage Biomarkers (2018)

Treatment modalities for cancer radiation therapy have become increasingly diversified given the growing number of facilities providing proton and carbon-ion therapy in addition to the more historically accepted photon therapy. An understanding of high-LET radiobiology is critical for optimization of charged particle radiation therapy and potential DNA damage response. In this review, we present a comprehensive summary and comparison of these types of therapy monitored primarily by using DNA damage biomarkers. We focus on their relative profiles of dose distribution and mechanisms of action from the level of nucleic acid to tumor cell death.
Transient Deficit of Accommodation After Laser Barrage for Retinal Tear (2015)

We believe that transient loss of accommodation, although rare, should be included during pretreatment discussion with young patients regarding the possible side effects of laser photocoagulation, even if this is limited to a small area of the peripheral retina.
Supplemental Figure 2 from Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen (2023)

&lt;p&gt;Supplemental Figure 2. Tumor growth was similar in FXIII-/- (n = 6) and control (n = 8) male mice following injection of MC38 cells into dorsal subcutis as measured by serial calipation and tumor mass at sacrifice.&lt;/p&gt;
A Detailing Method for Improving Leakage Prevention of Exterior Wall Weatherproofing (2003)

As generally or often practiced, building design and construction detailing of weatherproofing exterior building walls relies on two-dimensional (2-D) graphic representations of building components to indicate materials used for weatherproofing. However, these details which serve a variety of purposes for different users do not show all the relevant materials needed to construct a weatherproof exterior wall. The various users of construction details, e.g., contractors, builders and material installers, utilize these 2-D drawings as visual instruction guides for constructing and installing building components. Common construction details are intended to show various components that serve a variety of purposes, such as structural support, fire-resistance, energy control, acoustic control, aesthetic appearance and incidentally weatherproofing. Different contractors during construction will review the same detail to obtain information relevant to the purposes of their particular trade. Construction details usually identify a material or component by name and not by the trade that constructs it or the purpose it serves. Construction details, in addition to traditional uses, need to focus and emphasize weatherproofing materials and assemblies. Three-dimensional details should be used to show the junctures of exterior wall construction where weatherproofing installation is critical. Sequence (Step-by-Step) views should be used to show the layering of weather barriers and flashings in the proper order of installation. Enlarged cross-section details should be used to identify and show what weatherproofing materials are required and where they are installed.
Understanding Dynamic Spectrum Sharing: Field to Lab Methodology and Case Study (2021)

With the demand to fulfill the insatiable appetite for voice, video, and data connectivity anywhere and anytime, the need for more spectrum bandwidth is a never ending challenge. When considering available spectrum, the NTIA and FCC have focused on spectrum that appears viable for coexistence through a measure of dynamic spectrum sharing (DSS). Recent technology and standards enhancement for dynamic access control, frequency selection, and detect and avoid technologies show promise to enable the successful sharing of occupied spectrum.
The clock-drawing test as a possible indicator of acute psychosis (2016)

The clock-drawing test (CDT) is used widely to evaluate cognitive disorders, but its role in the assessment of psychotic disorders has not been studied. We sought to examine whether the CDT plays a role as an indicator of psychosis and to establish its sensitivity to clinical improvement of psychosis. The CDT was administered twice to 53 hospitalized patients without dementia but with psychosis: once at admission and again before discharge. The CDT scores were calculated in a random order by two independent senior psychiatrists who were blinded to the patients' status (admission or discharge). The inter-rater reliability was high (0.89 at admission, 0.85 at discharge, P<0.01 for both). The severity of psychosis was assessed by the Positive and Negative Syndrome Scale (PANSS). Patients had significantly lower CDT scores at admission than at discharge (2.87±1.39 vs. 3.91±1.08, respectively, P<0.01). The PANSS-total score of the patients showed a significant improvement (84.90±17.77 vs. 69.18±16.23, P<0.01). An inverse correlation was found between CDT performance and psychosis severity, as reflected by the PANSS-positive symptom subscale at admission (R=-0.279, P<0.05). Our findings suggest that the CDT may aid in the assessment of psychotic states and in their clinical monitoring.
Supplementary Table 2 Legend from Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow (2023)

Supplementary Table 2 Legend from Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow
Inverse Flux Analysis for Reduction of Acetate Excretion in Escherichia coli (1997)

The determination of intracellular fluxes from the measurement of extracellular rates, a technique known as flux analysis, has been used successfully on several systems important to biotechnology. However, calculation of intracellular fluxes does not directly suggest ways to improve the performance of the cell. Here, we introduce a variation of this analysis, termed inverse flux analysis, which allows the prediction of the flux distribution as a function of manipulable internal fluxes. This approach is applied to analyze the acetate excretion problem commonly observed in aerobic Escherichia coli cultures. The effect of manipulating each flux is quantified by a flux distribution sensitivity coefficient, which is dependent on the stoichiometry. For the acetate excretion problem, our results suggest that the anaplerotic pathways, including the reactions catalyzed by phosphoenolpyruvate carboxylase and the glyoxylate bypass are the best choices for manipulating acetate excretion in E. coli. Increasing the anaplerotic flux will decrease acetate production while increasing the growth yield.
Sonoluminescence (1994)

In 1896, Henri Becquerel discovered that a uranium salt could darken a photographic plate, and from this effect went on to discover radioactivity. In 1934, Frenzel and Schultes discovered that acoustic waves, generated in a water bath, could also darken a photographic plate. They attributed this effect to luminescence from the sound field, a phenomenon that would later be known as sonoluminescence. A sound field by itself does not cause luminescence; it is through the mechanism of acoustic cavitation, whereby microscopic gas bubbles are caused to oscillate so violently that a remarkable energy concentration occurs. Under certain conditions, the cavitation event is transitory, and self-destructs within a few acoustic cycles; under other conditions, a stable bubble will luminesce for extended periods of time. This initial presentation will serve as a general review of the phenomenon of acoustic cavitation and demonstrate how bubble dynamics leads to many of the observed effects. Later papers in this session will provide more detail of various aspects of the general phenomenon. [Work supported in part by the Office of Naval Research.]
The Prevalence of Sarcopenia in Patients With Respiratory Failure Classified as Normally Nourished Using Computed Tomography and Subjective Global Assessment (2013)

Sarcopenia is highly prevalent among patients with respiratory failure requiring mechanical ventilation (MV) and not readily detected in patients classified as normal nourished using SGA.
FK506 Increases the Regeneration of Spinal Cord Axons in a Predegenerated Peripheral Nerve Autograft (1999)

The authors examined the ability of FK506 to accelerate axonal regeneration of rat spinal cord axons in a peripheral nerve (PN) graft. Predegenerated autografts were produced by transecting the left tibial nerve 1 week prior to spinal cord implantation into the lumbar (L-3-L-4) spinal cord. Rats were given daily injections of either FK506 (5 mg/kg, subcutaneous) or vehicle for 21 days. The PN grafts from FK506-treated rats contained larger sized regenerating axons compared with vehicle-treated controls, and mean axonal areas increased by 25% at 7.5 mm along the PN graft. Fluoro-Gold™ retrograde labeling confirmed that the regenerating axons originated from the central nervous system. Unexpectedly, the majority (> 50%) of neurons in the red nucleus were retrogradely labeled in the FK506-treated animals only. The results indicate that FK506 not only accelerates the elongation of spinal cord axons but also promotes regeneration of rubrospinal neurons.
Semiconductor Nanocrystals Photosensitize C60Crystals (2006)

Semiconductor nanocrystals (SCNCs) made of CdSe, CdTe, and InP are used to photosensitize needlelike C(60) crystals. The photocurrent is increased by up to 3 orders of magnitude as compared with C(60) crystals without SCNCs. The photocurrent spectrum can be tuned precisely by the SCNC size and material, rendering the SCNC-functionalized C(60) crystals an excellent material for spectrally tuneable photodetectors. We explain the increased photocurrent as a result of photoexcited electrons transferring from the SCNCs to the C(60) crystals and causing photoconductivity, while the complementary holes remain trapped in the SCNCs.
Crystallization and preliminary crystallographic analysis of the N‐terminal two domain fragment of vascular cell adhesion molecule‐1 (VCAM‐1) (1994)

A molecular fragment comprising the first two domains of the human vascular cell adhesion molecule-1 (VCAM-1) has been crystallized by the vapor diffusion method. Two crystal forms have been examined by X-ray analysis: One crystal form belongs to the space group C2 with two molecules in the asymmetric unit and cell parameters: a = 122.1 A, b = 48.9 A, c = 73.4 A, and beta = 117.4 degrees. The other crystal form belongs to the space group P2(1) with one molecule in the asymmetric unit and cell parameters: a = 40.4 A, b = 45.7 A, c = 54.7 A, and beta = 100.5 degrees. Diffraction data up to 1.9 A resolution have been collected for the C2 crystal form.
PACk (2022)

The Agglomerative Hierarchical Clustering (AHC) algorithm is widely used in real-world applications. As data volumes continue to grow, efficient scale-out techniques for AHC are becoming increasingly important. In this paper, we propose a Partition-based distributed Agglomerative Hierarchical Clustering (PACk) algorithm using novel distance-based partitioning and distance-aware merging techniques. We have developed an efficient implementation of PACk on Spark. Compared to the state-of-the-art distributed AHC algorithm, PACk achieves 2X to 19X (median=9X) speedup across a variety of synthetic and real-world datasets.
High-frequency surface acoustic wave propagation in nanostructures characterized by coherent extreme ultraviolet beams (2009)

We study ultrahigh frequency surface acoustic wave propagation in nickel-on-sapphire nanostructures. The use of ultrafast, coherent, extreme ultraviolet beams allows us to extend optical measurements of propagation dynamics of surface acoustic waves to frequencies of nearly 50 GHz, corresponding to wavelengths as short as 125 nm. We repeat the measurement on a sequence of nanostructured samples to observe surface acoustic wave dispersion in a nanostructure series. These measurements are critical for accurate characterization of interfaces beneath very thin films using this technique.
Rare surfactant‐related variants in familial and sporadic pulmonary fibrosis (2022)

The role of constitutional genetic defects in idiopathic pulmonary fibrosis (IPF) is increasingly appreciated. Monogenic disorders associated with IPF affect two pathways: telomere maintenance, accounting for approximately 10% of all patients with IPF, and surfactant biology, responsible for 1%-3% of cases and often co-occurring with lung cancer. We examined the prevalence of rare variants in five surfactant-related genes, SFTPA1, SFPTA2, SFTPC, ABCA3, and NKX2-1, that were previously linked to lung disease in whole genome sequencing data from 431 patients with IPF. We identified functionally deleterious rare variants in SFTPA2 with a prevalence of 1.3% in individuals with and without a family history of IPF. All individuals had no personal history of lung cancer, but substantial bronchiolar metaplasia was noted on lung explants and biopsies. Five patients had novel missense variants in NKX2-1, but the contribution to disease is unclear. In general, patients were younger and had longer telomeres compared with the majority of patients with IPF suggesting that these features may be useful for identifying this subset of patients in the clinic. These data suggest that SFTPA2 variants may be more common in unselected IPF cohorts and may manifest in the absence of personal/family history of lung cancer or IPF.