gebhart/patrepeval huggingface dataset:
Attenuation of pile driving noise using a double walled sound shield (2012)

Pile driving in water produces high sound levels in underwater environments. The associated pressures are known to produce deleterious effects on both fish and marine mammals. We present an evaluation of the effectiveness of surrounding the pile with a double walled sound shield to decrease impact pile driving noise. Four 32 m long, 76 cm diameter piles were driven 14 m into the sediment with a vibratory hammer. A double walled sound shield was then installed around the pile, and the pile was impact driven another 3 m while sound measurements were obtained. The last 0.3 m was driven with the sound shield removed, and data were collected for the untreated pile. The sound field obtained by finite element analysis is shown to agree well with measure data. The effectiveness of the sound shield is found to be limited by the fact that an upward moving Mach wave is produced in the sediment after the first reflection of the deformation wave against the bottom end of the pile. The sound reduction obtained through the use of the sound shield, as measured 10 meters away from the pile, is shown to be approximately 12dB dB re 1 μPa.
TFCX Current Density and Nuclear Heating Limitations for Superconducting Tokamaks (1985)

A major goal of the Tokamak Fusion Core Experiment (TFCX) study was to minimize the size of the device and achieve lowest cost. Two key factors influencing the size of the device employing superconducting magnets are toroidal field (TF) winding current density and its nuclear heat load withstand capability. Lower winding current density requires larger radial build of the winding pack. Likewise, lower allowable nuclear heating in the winding requires larger shield thickness between the plasma and coil. To achieve a low-cost device, it is essential to maximize the winding's current density and nuclear heating withstand capability. To meet this objective, the TFCX design specification adopted as goals a nominal winding current density of 3500 A/cm2 with 10-T peak field at the winding, peak nuclear heat load limits of 1 mW/cm3 for the nominal design and 50 mW/cm3 for an advanced design. This study developed justification for these current density and nuclear heat load limits.
Effect of Multiple‐Dose Diltiazem on the Pharmacokinetics of the Renin Inhibitor ACT‐077825 (2013)

This open-label, randomized study evaluated the effects of steady-state diltiazem on the pharmacokinetic, safety, and tolerability profile of a single dose of the novel renin inhibitor ACT-077825. Twelve healthy Caucasian male subjects (20-50 years) received in treatment sequence A, a single dose of 100 mg ACT-077825 (Days 1 and 17), and oral diltiazem 300 mg once daily (Days 14-26). In treatment sequence B, subjects received a single dose of 100 mg ACT-077825 (Days 4 and 22) and oral diltiazem 300 mg once daily (Days 1-13). ACT-077825 alone and combined with diltiazem was generally well tolerated. On average, the systemic exposure to ACT-077825 was higher in the presence of diltiazem. For AUC0-∞ and t1/2 , the upper limit of the 90% confidence interval (CI) of the geometric mean ratios was outside the study-specific 0.5-2.0 equivalence boundaries, that is, 1.92 (90% CI: 1.30, 2.83) and 1.58 (90% CI: 1.22, 2.04), respectively. In conclusion, diltiazem markedly affected the pharmacokinetics of ACT-077825, probably via inhibition of CYP3A4 activity, without changing its safety and tolerability profile in healthy male subjects. Whether such an interaction will require for therapeutic dose adjustment of ACT-077825 co-administered with diltiazem has to be assessed once the dose-response relationship of ACT-077825 in hypertensive patients is determined.
Optimal Control of Virtual Batteries using Stochastic Linearization (2021)

Stochastic Linearization (SL) is a method of linearizing a nonlinearity that, unlike traditional Jacobian linearization that is valid only close to the operating point, uses statistical properties of the input to render the linearization fairly accurate over a wide range of inputs. In this paper, the method of SL is applied to optimally design controllers for an aggregation of distributed energy resources (DERs), called a virtual battery (VB), by taking into account the solar penetration levels, grid parameters, and the VB power limits. Analysis and simulation results show that VB performance can be greatly improved over a baseline design that ignores VB power limits, and that the controllers can be adaptively designed to effectively respond to changes in system parameters. This proves to be a new method for designing controllers to improve the participation of power-constrained VBs.
Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension (2017)

It is widely accepted that impaired bioavailability of endothelial nitric oxide (NO) plays a critical role in the pathophysiology of pulmonary arterial hypertension (PAH). However, there are published data that show that relatively many PAH patients respond favorably to acetylcholine-induced pulmonary vasodilation during their follow-up period, when diverse stages of the disorder are included. We hypothesized that NO bioavailability varies depending on the progression of PAH Adult rats were exposed to the VEGF receptor blocker Sugen5416 and 3 weeks of hypoxia followed by return to normoxia for various additional weeks. All rats developed increased right ventricular systolic pressure (RVSP) and occlusive lesion formation at 1, 3, 5, and 8 weeks after the Sugen5416 injection. Acute NO synthase blockade did not change the elevated RVSP at the 1-week time point, while it further increased RVSP markedly at the 3-, 5-, and 8-week time points, leading to death in all rats tested at 8 weeks. Acetylcholine caused significant reduction in RVSP at the 8-week but not the 1-week time point, whereas sodium nitroprusside decreased the pressure similarly at both time points. Increased NO-mediated cGMP production was found in lungs from the 8-week but not the 1-week time point. In conclusion, despite its initial impairment, NO bioavailability is restored and endogenous NO plays a critical protective role by counteracting severe pulmonary vasoconstriction in established stages of PAH in the Sugen5416/hypoxia/normoxia-exposed rats. Our results provide solid pharmacological evidence for a major contribution of a NO-suppressed vasoconstrictor component in the pathophysiology of established PAH.
PET/Graphene Compatibilization for Different Aspect Ratio Graphenes via Trimellitic Anhydride Functionalization (2020)

Two trimellitic anhydride-functionalized, thermally reduced graphenes with different aspect ratios, <i>A</i> <sub>f</sub>, and the same C/O ratio (8:1) were prepared and melt-mixed into poly(ethylene terephthalate) (PET), and the mechanical properties of the resulting nanocomposites were studied with a focus on plastic deformation behavior. A slight increase in the <i>G</i>' of the melt was observed for the surface-modified low-<i>A</i> <sub>f</sub> graphene composites (<i>A</i> <sub>f</sub> = 20) below the percolation threshold, whereas a significant enhancement in <i>G</i>' was observed for higher-<i>A</i> <sub>f</sub> graphene composites (<i>A</i> <sub>f</sub> = 80) at all graphene loadings, both below and above the percolation concentration. Furthermore, the use of modified low-<i>A</i> <sub>f</sub> graphene caused an improvement both in Young's modulus and elongation at break of the resulting PET nanocomposites because of enhancement of interfacial adhesion between filler and matrix which resulted in the formation of a coupled network via covalent bonding and the suppression both of strain-induced orientation and strain-induced crystallization. By contrast, the use of modified higher-<i>A</i> <sub>f</sub> surface graphene in nanocomposites caused a drastic improvement in Young's modulus but lower elongation-at-break than with the unmodified counterpart; the former effect is due to the formation of denser coupled networks and stronger interfacial adhesion as a result of graphene surface modification and the latter is due to the added geometrical restriction in unentangling chains from the PET matrix in the presence of higher-<i>A</i> <sub>f</sub> graphene. The preceding observations demonstrate the potential impacts of tuning both surface chemistry and aspect ratio of graphene in the fabrication of PET/graphene composites.
Effects of boundary-layer separation controllers on a desktop fume hood (2016)

A desktop fume hood installed with an innovative design of flow boundary-layer separation controllers on the leading edges of the side plates, work surface, and corners was developed and characterized for its flow and containment leakage characteristics. The geometric features of the developed desktop fume hood included a rearward offset suction slot, two side plates, two side-plate boundary-layer separation controllers on the leading edges of the side plates, a slanted surface on the leading edge of the work surface, and two small triangular plates on the upper left and right corners of the hood face. The flow characteristics were examined using the laser-assisted smoke flow visualization technique. The containment leakages were measured by the tracer gas (sulphur hexafluoride) detection method on the hood face plane with a mannequin installed in front of the hood. The results of flow visualization showed that the smoke dispersions induced by the boundary-layer separations on the leading edges of the side plates and work surface, as well as the three-dimensional complex flows on the upper-left and -right corners of the hood face, were effectively alleviated by the boundary-layer separation controllers. The results of the tracer gas detection method with a mannequin standing in front of the hood showed that the leakage levels were negligibly small (≤0.003 ppm) at low face velocities (≥0.19 m/s).
Photodynamic Therapy: Porous Porphyrin‐Based Organosilica Nanoparticles for NIR Two‐Photon Photodynamic Therapy and Gene Delivery in Zebrafish (Adv. Funct. Mater. 21/2018) (2018)

Porphyrin-based mesoporous organosilica nanoparticles are designed by Nadir Bettache, Jean-Olivier Durand, and co-workers in article number 1800235. These nanoparticles possess a high specific surface area and large mesopores of 10–80 nm diameters. Two-photon photodynamic therapy of breast cancer and siRNA delivery were both performed in zebrafish embryos and were very efficient.
Optical Properties of Oriented Polymer/Dye Polarizers. 2. Ultimate Properties (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTOptical Properties of Oriented Polymer/Dye Polarizers. 2. Ultimate PropertiesY. Dirix, T. A. Tervoort, and C. BastiaansenView Author Information Eindhoven Polymer Laboratories, Faculty of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands, and Polymertechnologie, Institut für Polymere, ETH Zürich, ETH Zentrum, UNO C 15, Universitätstrasse 41, CH-8092, Zürich, Switzerland Cite this: Macromolecules 1997, 30, 7, 2175–2177Publication Date (Web):April 7, 1997Publication History Received4 June 1996Revised3 January 1997Published online7 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ma960808xhttps://doi.org/10.1021/ma960808xbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views532Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Dyes and pigments,Optical properties,Polymers,Theoretical and computational chemistry Get e-Alerts
Carbon doped PDMS: conductance stability over time and implications for additive manufacturing of stretchable electronics (2017)

Carbon doped PDMS (cPDMS), has been used as a conductive polymer for stretchable electronics. Compared to liquid metals, cPDMS is low cost and is easier to process or to print with an additive manufacturing process. However, changes on the conductance of the carbon based conductive PDMS (cPDMS) were observed over time, in particular after integration of cPDMS and the insulating polymer. In this article we investigate the process parameters that lead to improved stability over conductance of the cPDMS over time. Slight modifications to the fabrication process parameters were conducted and changes on the conductance of the samples for each method were monitored. Results suggested that change of the conductance happens mostly after integration of a pre-polymer over a cured cPDMS, and not after integration of the cPDMS over a cured insulating polymer. We show that such changes can be eliminated by adjusting the integration priority between the conductive and insulating polymers, by selecting the right curing temperature, changing the concentration of the carbon particles and the thickness of the conductive traces, and when possible by changing the insulating polymer material. In this way, we obtained important conclusions regarding the effect of these parameters on the change of the conductance over time, that should be considered for additive manufacturing of soft electronics. Also, we show that these changes can be possibly due to the diffusion from PDMS into cPDMS.
Metal Ion Complexation Studies of Novel 8-Hydroxyquinoline-Containing Diaza-18-Crown-6 Ligands and Analogues. (1999)

Abstract : Interaction of some 8-hydroxyquinoline-substituted and related ligands (see Figure 1) with various metal ions was evaluated by a calorimetric titration technique at 25 deg C in MeOH. Bis-(8-hydroxyquinoline-2-ylmethyl)-substituted ligand 13 forms a very strong complex with Ba(2+) (log K = 11.6 in MeOH) and is highly selective for Ba(2+) over Na(+), K(+), Zn(2+) and Cu(2+) (selectivity factor > 10(exp 6)). The H1 NMR spectral studies of the Ba(2+) complexes with bis-(8-hydroxyquinoline-2-ylmethyl)- and bis(5,7-dichloro-8-hydroxyquinoline-2-ylmethyl)-substituted diaza-18-crown-6 ligands (13 and 10) suggest that these complexes are cryptate-like structures with two overlapping hydroxyquinoline rings forming a pseudo second.
C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Aldol Additions of Silylketene Acetals to (Benzyloxy)acetaldehyde (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTC2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Aldol Additions of Silylketene Acetals to (Benzyloxy)acetaldehydeDavid A. Evans, Jerry A. Murry, and Marisa C. KozlowskiView Author Information Department of Chemistry, Harvard University Cambridge, Massachusetts 02138 Cite this: J. Am. Chem. Soc. 1996, 118, 24, 5814–5815Publication Date (Web):June 19, 1996Publication History Received5 March 1996Published online19 June 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja960712ihttps://doi.org/10.1021/ja960712irapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views3229Altmetric-Citations229LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Aldol reactions,Catalysts,Lewis acids,Separation science Get e-Alerts
Design and Synthesis of Biotin Chain-Terminated Glycopolymers for Surface Glycoengineering (2002)

Biotin chain-terminated glycopolymers were generated by cyanoxyl-mediated free-radical polymerization using a biotin-derivatized arylamine initiator with high conversion (75%) and low polydispersity (1.30). Streptavidin-biotinylated glycopolymer binding was verified by SDS-PAGE gel shift assay and patterned glycocalyx-mimetic surfaces successfully fabricated.
Correction: Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells (2020)

[This corrects the article DOI: 10.1371/journal.pone.0179501.].
A Novel OFDM Training Sequence Strategy Based on a Sliding Window for Optical Burst Traffic (2018)

In order to mitigate the transients occurring in the coherent receivers facing an absence of burst, a novel channel estimator, using a sliding window, is proposed here for optical DP-16QAM-OFDM burst traffic. Our experimental results show a significant performance gain of this new estimator resulting in an error threshold cancellation.
Southeast Michigan 2014 Test Bed project architecture: Implementing the USDOT's Connected Vehicle Reference Implementation Architecture (2013)

The US Department of Transportation's (USDOT) Southeast Michigan Connected Vehicle Test Bed originally hosted the USDOT Proof of Concept Testing (POC), starting in 2007. At that time, the architecture was designed around what was referred to as the Service Delivery Node (SDN). The SDN was a relatively closed system that handled data “collection”, processing (applications) and data dissemination back to the vehicle. While effective for these early tests and development efforts, this closed architecture was not conducive to growth and expansion. The USDOT, following the success of the POC, initiated the development of a Connected Vehicle Reference Implementation Architecture (CVRIA), and in 2013 began the final design of trial implementation of the CVRIA at the USDOT's Southeast Michigan Connected Vehicle Test Bed. All users of this facility will be encouraged to develop and deploy solutions (hardware and software) using a common graphical language that is based on the updated ITS National Architecture. The authors will present the Southeast Michigan 2014 Test Bed architecture as it is being designed and deployed in this trial, describing the different architectural views and how they will lead to final design documentation. The Test Bed must be built to accommodate a wide range of user agreements, to be secure as well as accessible to a wide range of users, the traveler — often multi-modal, commercial and transportation providers and authorities. In this paper we present the proposed system architecture and our process for evaluation through industry collaboration.
Modulation of Gonococcal Piliation by Regulatable Transcription of pilE (2001)

The gonococcal pilus, a member of the type IV family of pili, is composed of numerous monomers of the pilin protein and plays an important role in the initiation of disease by providing the primary attachment of the bacterial cell to human mucosal tissues. Piliation also correlates with efficient DNA transformation. To investigate the relationships between these pilus-related functions, the piliation state, and the availability of pilin, we constructed a derivative of MS11-C9 (DeltapilE1) in which the lacIOP regulatory sequences control pilE transcription. In this strain, MS11-C9.10, the steady-state levels of pilin mRNA and protein directly correlate with the concentration of IPTG (isopropyl-beta-D-thiogalactopyranoside) in the growth medium and can reach near-wild-type levels of expression. Transmission electron microscopy (TEM) demonstrated that the number of pili per cell correlated with the steady-state expression levels: at a low level of transcription, single long pili were observed; at a moderate expression level, many singular and bundled pili were expressed; and upon full gene expression, increased lateral association between pili was observed. Analysis of pilus assembly by TEM and epithelial cell adherence over a time course of induction demonstrated that pili were expressed as early as 1 h postinduction. Analysis at different steady-state levels of transcription demonstrated that DNA transformation efficiency and adherence of MS11-C9.10 to transformed and primary epithelial cells also correlated with the level of piliation. These data show that modulation of the level of pilE transcription, without a change in pilE sequence, can alter the number of pili expressed per cell, pilus bundling, DNA transformation competence, and epithelial cell adherence of the gonococcus.
The effects of public health policies on health inequalities in high-income countries: an umbrella review (2018)

PROSPERO registration number: CRD42016025283.
Real-Time Head Pose Estimation on Mobile Platforms (2010)

Many computer vision applications such as augmented reality require head pose estimation. As far as the real-time implementation of head pose estimation on relatively resource limited mobile platforms is concerned, it is required to satisfy real-time constraints while maintaining reasonable head pose estimation accuracy. The introduced head pose estimation approach in this paper is an attempt to meet this objective. The approach consists of the following components: Viola-Jones face detection, color-based face tracking using an online calibration procedure, and head pose estimation using Hu moment features and Fisher linear discriminant. Experimental results running on an actual mobile device are reported exhibiting both the real- time and accuracy aspects of the developed approach.
Integrating multiomics longitudinal data to reconstruct networks underlying lung development (2019)

A comprehensive understanding of the dynamic regulatory networks that govern postnatal alveolar lung development is still lacking. To construct such a model, we profiled mRNA, microRNA, DNA methylation, and proteomics of developing murine alveoli isolated by laser capture microdissection at 14 predetermined time points. We developed a detailed comprehensive and interactive model that provides information about the major expression trajectories, the regulators of specific key events, and the impact of epigenetic changes. Intersecting the model with single-cell RNA-Seq data led to the identification of active pathways in multiple or individual cell types. We then constructed a similar model for human lung development by profiling time-series human omics data sets. Several key pathways and regulators are shared between the reconstructed models. We experimentally validated the activity of a number of predicted regulators, leading to new insights about the regulation of innate immunity during lung development.