gebhart/patrepeval huggingface dataset:
Inverse emulsion polymerization of acrylamide in supercritical carbon dioxide. [Erratum to document cited in CA120:55125] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInverse emulsion polymerization of acrylamide in supercritical carbon dioxide. [Erratum to document cited in CA120:55125]F. A. Adamsky and E. J. BeckmanCite this: Macromolecules 1994, 27, 18, 5238Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ma00096a061https://doi.org/10.1021/ma00096a061research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced Oil Recovery in Liquid-Rich Shale Reservoirs: Laboratory to Field (2015)

Abstract Production of tight oil from shale reservoirs in North America reduces oil imports and has better economics than natural gas. Consequently, there is a strong interest in oil production from Bakken, Eagle Ford, and Niobrara. However, oil recovery factor for Bakken remains low, which is about four to six percent of the oil in place. Even with this low oil recovery factor, Bakken recoverable reserves are estimated to be 7.4 billion barrels; thus, a large volume of oil will remain unrecovered. This low level of oil recovery was the motivation to investigate the feasibility of enhanced oil recovery (EOR) in liquid-rich shale reservoirs such as Bakken. In this paper, we will present both laboratory and numerical modeling of EOR in Bakken cores using CO2, C1-C2 mixture, and N2. The laboratory experiments were conducted at the Energy and Environmental Research Center (EERC). The experiments recovered 90+ percent oil from several Middle Bakken cores and nearly 40 percent from Lower Bakken cores. To decipher the oil recovery mechanisms in the experiments, a numerical compositional model was constructed to match laboratory oil recovery results. We concluded that solvent injection mobilizes matrix oil by miscible mixing and solvent extraction in a narrow region near the fracture-matrix interface, thus promoting counter-current flow of oil from the matrix instead of oil displacement through the matrix. Specifically, compositional modeling results indicate that the main oil recovery mechanism is miscible oil extraction at the matrix-fracture interface region. However, the controlling factors include re-pressurization, oil swelling, viscosity and interfacial tension reduction, diffusion-advection mass transfer, and wettability alternation. We scaled up laboratory results to field applications via a compositional numerical model. For field applications, we resorted to the huff-and-puff protocol to assess the EOR potential for a North Dakota Middle Bakken well. We concluded that long soak times yields only a small additional oil compared to short soak times, and re-injecting wet gas, composed of C1,C2, C3, and C4+, produces nearly as much oil as CO2 injection.
ChemInform Abstract: Metal‐Free Multicomponent Syntheses of Pyridines (2015)

Abstract Review: 306 refs.
Supplementary Figures from The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells (2023)

&lt;p&gt;Supplementary Figures - Supplementary Figures - PDF file 1005K, Fig S1. DAB2IP knockdown enhances Egr1 and sCLU expression. Fig S2. Wnt treatment enhances sCLU expression and Egr1 promoter activity in prostate cells. Fig S3. Wnt/beta-catenin regulates production of the IGF-1-sCLU expression axis. Fig S4. Deletion of NF-{kappa}B binding sites within the Egr1 promoter has no effect on its repression by DAB2IP. Fig S5. Egr1 and sCLU protein expression increased in PCa tissues following androgen-deprived therapy&lt;/p&gt;
C60·Bromobenzene Solvate:  Crystallographic and Thermochemical Studies and Their Relationship to C60 Solubility in Bromobenzene (1998)

Differential scanning calorimetry, solution calorimetry, and room-temperature single-crystal X-ray diffraction were used to study the thermodynamic and structural properties of a solvated crystal C60·2C6H5Br. In the monoclinic solvate, two orientations of C60 were observed with fractional populations of 0.71 and 0.29. The enthalpy of solution of pure C60 in bromobenzene was determined to be ΔsolH[C60(s)] = −11.5 ± 2.0 kJ/mol. The enthalpy of solution of the solvated crystal was ΔsolH[C60·2C6H5Br(s)] = +28 ± 1 kJ/mol. The phase diagram of the system C60−C6H5Br for T < 423 K was constructed. It predicts the existence of a maximum in the temperature−solubility relationship for C60 in bromobenzene at 350 K. The activity of bromobenzene vapor over the solvated crystal is predicted to be reduced from its value over the pure liquid by a factor of 3.5.
Fast Algorithms for Model-based Imaging through Turbulence (2020)

Digital holography (DH) systems have the potential to perform single-shot imaging through deep turbulence by incorporating emerging algorithms, such as model-based iterative reconstruction (MBIR), that jointly estimate both the phase-errors and speckle-free image. However, the high computational cost of MBIR poses a challenge for use in practical applications. In this paper, we propose a method that makes MBIR feasible for real-time DH systems. Our method uses surrogate optimization techniques to simplify and speed up the reflectance and phase-error updates in MBIR. Further, our method accelerates computation of the surrogate-updates by leveraging cache-prefetching and SIMD vector processing units on each CPU core. We analyze the convergence and real CPU time of our method using simulated data sets, and demonstrate its dramatic speedup over the original MBIR approach.
Hemiepiphysiodesis for the correction of proximal tibial valgus in growing dogs (2016)

Hemiepiphysiodesis for the treatment of proximal tibial valgus is a technique that allows for reduction in mMPTA and should be considered as an early treatment for immature animals that are presented with proximal tibial deformities. Serial radiographs to monitor for overcorrection should be performed. Implant removal should be considered if overcorrection occurs, taking into consideration that rebound growth may be observed.
One-phase CCD: a new approach to charge-coupled device clocking (1972)

A new approach to charge-coupled device (CCD) clocking has been developed that uses a single clock signal and dc bias on a device structure previously used for two-phase clocking. The one-phase approach results in improved operation by simplifying the clock circuit, reducing power consumption, and simplifying scanning of large CCD arrays.
Stabilizations of Gyrotron frequency and power by PID double feedback control on the acceleration and anode voltages (2016)

The results of both gyrotron output power and frequency stabilization by double PID feedback control of acceleration voltage and anode voltage have been presented. The second harmonic 460 GHz Gyrotron with isolated collector has been used in the stabilization experiment. In the long term experiment, the frequency stabilization was better than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> and the power stabilization was better than ±1%.
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure (2017)

Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of cellular antioxidant networks. Here we investigated interactions between PTP1B and the peroxiredoxin 2 (Prx2)/thioredoxin 1 (Trx1)/thioredoxin reductase 1 (TrxR1) network. We found that Prx2 becomes oxidized in PDGF-treated fibroblasts, but only when TrxR1 has first been inhibited. Using purified proteins, we also found that PTP1B is relatively insensitive to inactivation by H<sub>2</sub>O<sub>2</sub> but found no evidence for a relay mechanism in which Prx2 or Trx1 facilitates PTP1B oxidation. Instead, these proteins prevented PTP1B inactivation by H<sub>2</sub>O<sub>2</sub> Intriguingly, we discovered that TrxR1/NADPH directly protects PTP1B from inactivation when present during the H<sub>2</sub>O<sub>2</sub> exposure. This protection was dependent on the concentration of TrxR1 and independent of Trx1 and Prx2. The protection was blocked by auranofin and required an intact selenocysteine residue in TrxR1. This activity likely involves reduction of the sulfenic acid intermediate form of PTP1B by TrxR1 and is therefore distinct from the previously described reactivation of end-point oxidized PTP1B, which requires both Trx1 and TrxR1. The ability of TrxR1 to directly reduce an oxidized phosphatase is a novel activity that can help explain previously observed increases in PTP1B oxidation and PDGF receptor phosphorylation in TrxR1 knockout cells. The activity of TrxR1 is therefore of potential relevance for understanding the mechanisms of redox regulation of growth factor signaling pathways.
Analytical and Experimental Investigation of a Low Torque, Ultra-High Speed Drive System (2006)

New application areas are demanding the development of ultra-high speed electrical machines. Significant challenges exist to produce a test bench that is capable of withstanding operating speeds exceeding 500,000 rpm and measuring very low torque values of mNm. This paper describes a purpose built test bench that is able to characterize the operation of an ultra-high speed drive system. Furthermore, the calculation of electromagnetic losses, air friction and critical speeds is presented and a comparison of analytical and experimental results is given. The ultra-high speed machine has an efficiency of 95%, however, in the upper speed ranges the frictional losses become dominant
Wet Electrospinning of Poly(butylene succinate)(PBS) Copolyester into Helically Coiled 3D Structures (2018)

Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the fiber morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven membranes, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study successfully demonstrates the feasibility of using this method to process segmented copolyester poly(butylene succinate-co-dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer, into 3D helically coiled structures (HCS). A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.
Halothiophene Benzimidazoles as P1 Surrogates of Inhibitors of Blood Coagulation Factor Xa. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Workload acceleration with the IBM POWER vector-scalar architecture (2016)

In this paper, we describe the history and development of the IBM POWER <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> vector-scalar architecture, as well as how the design goals of hardware efficiency and software interoperability are achieved by integrating existing floating-point and vector functions into a new unified architecture and function unit. The vector-scalar instructions were defined with an emphasis on out-of-the-box performance and consumability, while accelerating a broad set of enterprise server workloads. Vector-scalar instructions were first introduced in the IBM POWER7 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> architecture to accelerate high-performance computing applications. With the introduction of the POWER8 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> processor, the vector-scalar architecture expanded to accelerate a diverse set of enterprise workloads including unstructured text and string processing, business analytics, in-memory databases, big data, and stream coding. We conclude this paper with a description of workload performance and application acceleration to demonstrate the effectiveness of the new vector-scalar architecture.
The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma (2018)

Renal cell carcinoma (RCC) is the most common form of kidney cancer. While cure remains exceptionally infrequent in RCC patients with systemic or recurrent disease, current targeted molecular strategies, including multi-targeted tyrosine kinase inhibitors (TKIs), notably changed the treatment paradigm of advanced renal cancer. Yet, complete and durable responses have been noted in only a few cases. Our studies reveal that sunitinib triggers two resistance-promoting signaling pathways in RCC cells, which emanate from the endoplasmic reticulum (ER) stress response: a PERK-driven ER stress response that induces expression of the pro-tumorigenic cytokines IL-6, IL-8, and TNF-α, and a TRAF2-mediated NF-κB survival program that protects tumor cells against cell death. PERK blockade completely prevents sunitinib-induced expression of IL-6, IL-8 and TNF-α, whereas NF-κB inhibition reinstates sensitivity of RCC cells to sunitinib both in vitro and in vivo. Taken together, our findings indicate that ER stress response may contribute to sunitinib resistance in RCC patients.
[1,1‐Co2(CO)6(CNAr)2]: A Structural Mimic of the Elusive D2d Isomer of [Co2(CO)8] (2013)

A long wait: Of the C2v, D3d and D2d isomers of [Co2(CO)8], the D2d isomer has eluded isolation and structural characterization for 50 years. A “D2d-type” isomer is also missing for the vast number of structurally characterized [Co2(CO)8−nLn] derivatives. The wait is over, as the bis-m-terphenyl isocyanide complex [1,1-Co2(CO)6(CNAr)2] is shown to serve as a structural mimic of the D2d form of [Co2(CO)8].
Screw Position Affects Dynamic Compression Plate Strain in an In Vitro Fracture Model (2001)

In a model simulating a comminuted fracture (gap), this study found that screws should be placed as close to the fracture site as possible to minimize plate strain. In an anatomically reduced two-part fracture model (no gap), widely spaced screws or those placed away from the fracture resulted in lower strains.
Effect of Cold Acclimation on Cold Resistance of Azuki Bean Beetle Callosobruchus chinensis L. (1994)

発育段階の異なるアズキゾウムシを用いて過冷却点,体重,炭水化物含量,低温下での生存に及ぼす低温順化の影響について調べた。1) 低温順化により幼虫,蛹の低温での生存期間が延長した。幼虫の高齢のものほど顕著であった。2) 幼虫,蛹,成虫の過冷却点はいずれも-20°Cより低かったことから,アズキゾウムシは一時的にかなりの低温に耐えられると考えられる。3) 幼虫,蛹で低温順化開始後グルコース,トレハロースといった糖の蓄積がみられたが,過冷却点はほぼ一定であった。また,低温順化後,0°Cに置かれた幼虫で糖やグリコーゲン含量の減少がみられた。4) 低温順化後,最も長く0°Cで生存したのは15日齢幼虫,次いで7日齢幼虫であった。それら幼虫の生存日数は最長で35日と20日であった。5) 以上の結果から,グリコーゲンや糖の蓄積が多かった老齢幼虫が越冬に適していると考えられる。
Spectroscopic and ab initio study of the interaction of molecular hydrogen with the isolated silica hydroxyls and related systems (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic and ab initio study of the interaction of molecular hydrogen with the isolated silica hydroxyls and related systemsE. Garrone, V. B. Kazanskii, L. M. Kustov, J. Sauer, I. N. Senchenya, and P. UgliengoCite this: J. Phys. Chem. 1992, 96, 3, 1040–1045Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/j100182a007https://doi.org/10.1021/j100182a007research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Next-generation large-scale binary protein interaction network for Drosophila (2022)

Abstract Generating reference maps of the interactome networks underlying most cellular functions can greatly illuminate genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes. Here, we applied state-of-the-art experimental and bioinformatics methods to identify high-confidence binary protein-protein interactions (PPIs) for Drosophila melanogaster . We performed four all-by-all yeast two-hybrid (Y2H) screens of &gt;10,000 Drosophila proteins, resulting in the ‘FlyBi’ dataset of 8,723 PPIs among 2,939 proteins. As part of this effort, we tested subsets of our data and data from previous PPI datasets using an orthogonal assay, which allowed us to normalize data quality across datasets. Next, we integrated our FlyBi data with previous PPI data, resulting in an expanded, high-confidence binary Drosophila reference interaction network, DroRI, comprising 17,232 interactions among 6,511 proteins. These data are accessible through the Molecular Interaction Search Tool (MIST) and other databases. To assess the utility of the PPI resource, we used novel interactions from the FlyBi dataset to generate an autophagy interaction network that we validated in vivo using two different autophagy-related assays. We found that deformed wings ( dwg ) encodes a protein that is both a regulator and a target of autophagy. Altogether, the resources generated in this project provide a strong foundation for building high-confidence new hypotheses regarding protein networks and function.
Anomalous positive-bias temperature instability of high-&#x03BA;/metal gate nMOSFET devices with Dy<inf>2</inf>O<inf>3</inf> capping (2008)

Recently, thin rare-earth oxide dielectric capping layers between the high-k and metal gate have been used to modulate the threshold voltage (Vt) of MOSFETs [Kirsch et al., 2006]. In Dy <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -capped high-k based devices, we observe an anomalous PBTI behavior where the Vt decreases during stress. Results suggest that there are two competing mechanisms - diffusion of preexisting positively-charged species and electron trapping. The charged species is likely located in the mixed high-k dielectric and associated with the interaction between the host dielectric, cap, and metal gate.
A low-cost, lightweight, flat and very-high-efficiency loudspeaker system for low frequencies (2005)

The introduction of concepts such as Flat TV and 5.1 channel sound reproduction systems has led to a renewed interest in obtaining a high sound output from compact loudspeaker arrangements with a high efficiency. Compact relates here to both the volume of the cabinet into which the loudspeaker is mounted as well as the cone area of the loudspeaker. Normally, low-frequency sound reproduction with small transducers is quite\ninefficient. To increase the efficiency, we map the low-frequency region, say from 20 to 120 Hz, to a single tone and use a special transducer with a very high efficiency at that particular tone.
Synthesis and Evaluation of New Endomorphin-2 Analogues Containing (Z)-α,β-Didehydrophenylalanine (ΔZPhe) Residues (2010)

New endomorphin-2 (EM-2) analogues incorporating (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) in place of the native phenylalanine in EM-2 are reported. Tyr-Pro-Delta(Z)Phe-Phe-NH(2) {[Delta(Z)Phe(3)]EM-2} (1), Tyr-Pro-Phe-Delta(Z)Phe-NH(2) {[Delta(Z)Phe(4)]EM-2} (2), and Tyr-Pro-Delta(Z)Phe-Delta(Z)Phe-NH(2) {[Delta(Z)Phe(3,4)]EM-2}(3) have been synthesized, their opioid receptor binding affinities and tissue bioassay activities were determined, and their conformational properties were examined. Compound 2 shows high mu opioid receptor selectivity and mu agonist activity comparable to those of the native peptide. The conformation adopted in solution and in the crystal by N-Boc-Tyr-Pro-Delta(Z)Phe-Phe-NH(2) (8) is reported.
Abstract #2430: Serum amyloid a (saa): a novel biomarker for uterine serous papillary cancer (2009)

Purpose:Serum Amyloid A (SAA) is an acute phase protein recently reported as a potentially useful biomarker for some human tumors. However, although SAA levels are inversely correlated to patient\#8217;s survival in several human malignancies, SAA is not considered a cancer-specific marker because its elevation in the serum of cancer patients is suggested to be of liver origin rather than a tumor cell product. In this study we investigated the expression of SAA in uterine serous papillary carcinoma (USPC), and evaluated its potential as a serum biomarker in this highly aggressive variant of endometrial cancer. Patients and Methods: SAA gene expression levels were evaluated in 22 snap frozen endometrial biopsies including 19 USPC and 3 normal endometrial control cell tissues (NEC) by real time-PCR. Protein expression and potential secretion of SAA by tumors was evaluated in primary USPC tumors and cell lines by flow cytometry and by a sensitive bead-based immunoassay, respectively. Finally, SAA concentration in 64 serum samples from 20 healthy women, 15 women with benign diseases, and 29 USPC patients were also studied. Results: SAA gene expression levels were significantly higher in USPC when compared to NEC (mean copy number by RT-PCR = 580 vs 2.6, USPC vs NEC: p Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2430.
ChemInform Abstract: Production of C4 and C5 Alcohols from Biomass‐Derived Materials (2016)

Abstract Review: 110 refs.