gebhart/patrepeval huggingface dataset:
Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases (2010)

Ischaemic tissue damage represents the ultimate form of tissue pathophysiology due to cardiovascular disease, which is the leading cause of morbidity and mortality across the globe. A significant amount of basic research and clinical investigation has been focused on identifying cellular and molecular pathways to alleviate tissue damage and dysfunction due to ischaemia and subsequent reperfusion. Over many years, the gaseous molecule nitric oxide (NO) has emerged as an important regulator of cardiovascular health as well as protector against tissue ischaemia and reperfusion injury. However, clinical translation of NO therapy for these pathophysiological conditions has not been realized for various reasons. Work from our laboratory and several others suggests that a new form of NO-associated therapy may be possible through the use of nitrite anion (sodium nitrite), a prodrug which can be reduced to NO in ischaemic tissues. In this manner, nitrite anion serves as a highly selective NO donor in ischaemic tissues without substantially altering otherwise normal tissue. This surprising and novel discovery has reinvigorated hopes for effectively restoring NO bioavailability in vulnerable tissues while continuing to reveal the complexity of NO biology and metabolism within the cardiovascular system. However, some concerns may exist regarding the effect of nitrite on carcinogenesis. This review highlights the emergence of nitrite anion as a selective NO prodrug for ischaemic tissue disorders and discusses the potential therapeutic utility of this agent for peripheral vascular disease.
ChemInform Abstract: A Total Synthesis of Galbonolide B (I). (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adenocarcinoma of the Prostate: I. Tissue Sampling Considerations (1993)

Adenocarcinoma of the Prostate: I. Tissue Sampling Considerations Get access Peter A. Humphrey, MD, Ph.D, Peter A. Humphrey, MD, Ph.D *Department of Pathology, Division of Surgical Pathology, Duke University Medical Center, Durham, North Carolina. Address reprint requests to Dr. Humphrey: Department of Pathology, Division of Surgical Pathology, Barnes Hospital at Washington University Medical Center, One Barnes Hospital Plaza, St. Louis, MO 63110. Search for other works by this author on: Oxford Academic Google Scholar Philip J. Walther, MD, Ph.D Philip J. Walther, MD, Ph.D †Department of Surgery, Division of Urology, Duke University Medical Center, Durham, North Carolina. Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 99, Issue 6, June 1993, Pages 746–759, https://doi.org/10.1093/ajcp/99.6.746 Published: 01 June 1993 Article history Accepted: 21 January 1992 Received: 29 October 1992 Published: 01 June 1993
Système de reconstruction cinématique corps entier : fusion et exploitation de données issues de MEMS (2011)

La democratisation des MEMS a permis l'essor des centrales d’attitude : groupement de capteurs permettant d'evaluer son orientation par rapport au repere terrestre. Il existe plusieurs types de capteurs utilises dans de telles centrales : les accelerometres, les magnetometres et les gyrometres. Seule la combinaison accelerometres – magnetometres – gyrometres permet l'estimation de l'orientation cinematique de facon satisfaisante, sans connaitre d'a priori sur le mouvement, c'est-a-dire l'estimation de l'orientation en presence d’acceleration inconnue. Le sujet de la these est justement, dans le cadre de la captation de mouvement corps entier, d'ajouter des connaissances a priori afin de limiter le nombre de gyrometres, voire de les supprimer totalement. Ces connaissances sont l'information que les capteurs sont fixes sur un squelette et que leurs mouvements relatifs ne peuvent etre que des compositions de rotations. Pour tester l'efficience de cette methode, on l'applique d'abord sur un pendule simple a un degre de liberte, puis sur un pendule a trois degres de liberte, ensuite sur des groupes de segments (epaule – bras – avant-bras par exemple) et sur le corps entier. Ce rapport de these developpera les aspects theoriques ainsi que les resultats obtenus sur les differentes methodologies de resolution.
Forward-error-control (FEC)-assisted adaptive equalization for digital cellular mobile radio (1993)

An adaptive equalization technique using forward error control coding is described and evaluated. Computer simulation is used to compare the FEC-assisted adaptive equalization to conventional adaptive equalization. The system model employed is based on the proposed digital cellular communication standard for North America. The FEC-assisted adaptive equalization technique performs better than the conventional equalization method at low and moderate Doppler frequencies with the same level of redundancy in the transmitted data. For systems employing both FEC coding and adaptive equalization, the FEC-assisted adaptive equalization method successfully combines these two functions while using the redundancy required for only one of them. In other words, training required for adaptive equalization can be provided at no extra cost in terms of data redundancy in a system using FEC coding and vice versa.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Long-term Cognitive Trajectory After Total Joint Arthroplasty (2022)

In this cohort study, long-term cognitive trajectories in individuals with and without TJA were largely similar except for a slightly faster decline among the oldest patients with TKA; however, the magnitude of difference was small and of unknown clinical significance.
QoS Control in Next-Generation networks[ Guest Editorial] (2007)

The three articles in this special section are devoted to quality of service control in next generation networking.
Tetrasubstituted 2,5-dihydrofuranols and their anomerism (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetrasubstituted 2,5-dihydrofuranols and their anomerismWarren M. Hankins, Robert E. Lutz, Elvin Lowell Anderson, Marie G. Hankins, and David W. Boykin Jr.Cite this: J. Org. Chem. 1970, 35, 9, 2934–2938Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/jo00834a018https://doi.org/10.1021/jo00834a018research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neuronal Activity in Motor Cortex and Related Areas (2012)

Abstract This chapter is organized into six sections. The first four discuss the anatomy and functional roles of the brain areas that are most relevant to the development of brain-computer interface technology. The final two sections discuss the information content of neuronal discharge recorded from these areas and review current methods for recording and analyzing spikes from many cortical neurons simultaneously. Although the cerebellum and basal ganglia play critical roles in the production of normal movements, their locations make them relatively inaccessible either to arrays of chronically implanted electrodes or to noninvasive electroencephalography. On the other hand, the exposed cerebral cortical surface is accessible to both electroencephalography electrodes and to the various types of implanted multielectrode arrays now available for recording neuronal action potentials (spikes).
A Simple Chemical Approach for PbTe Nanowires with Enhanced Thermoelectric Properties (2008)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionA Simple Chemical Approach for PbTe Nanowires with Enhanced Thermoelectric PropertiesQingyu Yan*, Hao Cheng, Wenwen Zhou, Huey Hoon Hng, Freddy Yin Chiang Boey, and Jan MaCite this: Chem. Mater. 2008, 20, 23, 7364Publication Date (Web):November 12, 2008Publication History Published online12 November 2008Published inissue 9 December 2008https://pubs.acs.org/doi/10.1021/cm803001yhttps://doi.org/10.1021/cm803001ycorrectionACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1086Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (18 KB) Get e-AlertscloseSUBJECTS:Nanowires,Thermoelectrics Get e-Alerts
Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage (2018)

Cigarette smokers and people exposed to second-hand smoke are at an increased risk for pulmonary viral infections, and yet the mechanism responsible for this heightened susceptibility is not understood. To understand the effect of cigarette smoke on susceptibility to viral infection, we used an air-liquid interface culture system and exposed primary human small airway epithelial cells (SAEC) to whole cigarette smoke, followed by treatment with the viral mimetic polyinosinic polycytidylic acid (poly I:C) or influenza A virus (IAV). We found that prior smoke exposure strongly inhibited production of proinflammatory (interleukin-6 and interleukin-8) and antiviral [interferon-γ-induced protein 10 (IP-10) and interferons] mediators in SAECs in response to poly I:C and IAV infection. Impaired antiviral responses corresponded to increased infection with IAV. This was associated with a decrease in phosphorylation of the key antiviral transcription factor interferon response factor 3 (IRF3). Here, we found that cigarette smoke exposure inhibited activation of Toll-like receptor 3 (TLR3) by impairing TLR3 cleavage, which was required for downstream phosphorylation of IRF3 and production of IP-10. These results identify a novel mechanism by which cigarette smoke exposure impairs antiviral responses in lung epithelial cells, which may contribute to increased susceptibility to respiratory infections.
Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements (2011)

Transcription factor p63, a p53 family member, plays a role in epithelial cell development, cell cycle arrest, apoptosis, and tumorigenesis. Point mutations, primarily in the DNA binding domain (p63DBD), lead to malformation syndromes. To gain insight into differences between p63 and p53 and the impact of mutations on the structure, we have determined two crystal structures of p63DBD in complex with A/T-rich response elements. One complex contains a 10-bp DNA half-site response element (5'AAACATGTTT3') and the other contains a 22-bp DNA full response element with a 2-bp spacer between two half-sites (5'AAACATGTTTTAAAACATGTTT3'). In both structures, each half-site binds a p63DBD dimer. The two p63DBD dimers do not interact in the presence of the DNA spacer, whereas they interact with one another in the p63DBD/10-bp complex where the DNA simulates a full response element by packing end-to-end. A unique dimer-dimer interaction involves a variable loop region, which differs in length and sequence from the counterpart loop of p53DBD. The DNA trajectories in both structures assume superhelical conformations. Surface plasmon resonance studies of p63DBD/DNA binding yielded K(d) = 11.7 μM for a continuous full response element, whereas binding was undetectable with the 22-bp DNA, suggesting an important contribution of a p63DBD interdimer interface to binding and establishing that p63DBD affinity to the response element is approximately 1,000-fold lower than that of p53DBD. Analyses of the structural consequences of p63DBD mutations that cause developmental defects show that, although some mutations affect DNA binding directly, the majority affects protein stability.
Simultaneous Ascending Auctions with Package Bidding (1998)

An effective package bidding mechanism addresses three problems: the exposure problem (the risks a bidder faces in trying to construct an efficiently large combination of licenses), the free-rider problem (the difficulties small bidders have in beating those who bid for larger packages of licenses), and the computational complexity problem (which arises from the fact that the number of possible combinations of licenses is much larger than the number of licenses). Package bidding offers the possibility of an improvement over individual-license bidding only when there are strong complementarities and the pattern of those complementarities varies across bidders. Package bidding works satisfactorily only when the auction rules have been carefully designed to manage all three problems.
Laser-induced fluorescence and biological analysis at the single-molecule level (1993)

We combine high sensitivity laser-induced fluorescence detection with capillary electrophoretic separation. The successful application of this technology has involved enzymatic reactions.
Methyltrioxorhenium Catalyzed Oxidation of 1,2‐Diols to 1,2‐Diketones Using Hydrogen Peroxide as Oxidant. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Derivation of human induced pluripotent stem cells through continued exposure of OCT4-induced plastic human fibroblasts to reprogramming media (2015)

The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment. Here we provide characterization of iPSCs established through continued culture of OCT4-induced plastic human fibroblasts in pluripotent-supportive reprogramming media. Human iPSC(OCT4) are morphologically indistinguishable from conventionally derived iPSCs and express core proteins involved in maintenance of pluripotency. iPSC(OCT4) display bona fide functional pluripotency as measured by in vivo teratoma formation consisting of the three germ layers.
Analysis of a continuous, aerobic, fixed‐film bioreactor. II. Dynamic behavior (1984)

The dynamic analysis of a continuous, aerobic, fixed-film bioreactor has been performed. Rigorous mathematical models have been developed for a fluidized-bed fermentor with biofilm growth. The transient performance of the reactor is appraised in terms of outlet penicillin concentration for constant, as well as variable carbon substrate feed rates. The effect of the reactor oxygen transfer capacity is elucidated for those cases employing substrate feeding strategies. The results show that penicillin production in a continuous, fixed-film bioreactor reaches a maximum with processing time, but subsequently decreases as cell mass accumulates and substrate deficiencies occur. The maximum production level can be maintained for increased operating times if the substrate supply is continuously increased. The duration of this prolonged production is a direct function of the rate of increase and the operating time at which the increase is initiated. The oxygen transfer capacity of the reactor was found to be important to the effectiveness of a feeding strategy.
A Liquid‐Metal–Elastomer Nanocomposite for Stretchable Dielectric Materials (2019)

Stretchable high-dielectric-constant materials are crucial for electronic applications in emerging domains such as wearable computing and soft robotics. While previous efforts have shown promising materials architectures in the form of dielectric nano-/microinclusions embedded in stretchable matrices, the limited mechanical compliance of these materials significantly limits their practical application as soft energy-harvesting/storage transducers and actuators. Here, a class of liquid metal (LM)-elastomer nanocomposites is presented with elastic and dielectric properties that make them uniquely suited for applications in soft-matter engineering. In particular, the role of droplet size is examined and it is found that embedding an elastomer with a polydisperse distribution of nanoscale LM inclusions can enhance its electrical permittivity without significantly degrading its elastic compliance, stretchability, or dielectric breakdown strength. In contrast, elastomers embedded with microscale droplets exhibit similar improvements in permittivity but a dramatic reduction in breakdown strength. The unique enabling properties and practicality of LM-elastomer nanocomposites for use in soft machines and electronics is demonstrated through enhancements in performance of a dielectric elastomer actuator and energy-harvesting transducer.
Quantum interference in chemical reactions (2018)

Interference much like that observed in two-slit experiments can be seen in the outcomes of chemical processes in which multiple reaction mechanisms lead to the same final state.
Study of the Rotational Isomerism and Synthesis of Glucosides Derived from Pyrazino[2,3‐c][1,2,6]thiadiazine 2,2‐Dioxides (1987)

Abstract Glucosidations of 4‐amino‐8 H ‐pyrazino[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxide and its 6,7‐dimethyl‐ and 6,7‐diphenyl derivatives via the “silylation method” are described. The reaction favors N‐1 substitution and the tetra‐ O ‐acetylglucopyranosyl derivatives 5, 6 , and 7 as well as the free nucleosides 8, 9 , and 10 have been isolated and characterized by UV, 1 H, and 2D‐NMR spectroscopy. The latter compound exist at room temperature, as rotationally restricted “ syn‐anti ” isomers, and the free energies of activation have been calculated.
Increasing localization robustness using directional antennas (2017)

Within this paper a novel approach for localization of roaming nodes is presented that uses static directional antennas at the receiver side to measure the received signal strength (RSS). In contrast to omni-directional antennas it is not possible to formulate an analytical relationship of distance to received signal power. The characteristics as well as benefits and challenges of directional antennas are analysed and a concept for an iterative approach is presented that uses a stored antenna pattern to estimate the transmitter position. Finally, a Bluetooth based measurement setup is presented, that will be used for the upcoming validation of the proposed algorithm.
Cardiac-Resynchronization Therapy for Heart Failure (2002)

The syndrome of congestive heart failure is responsible for substantial morbidity and mortality.1 Patients with heart failure have shortness of breath and a limited capacity for exercise, have high rates of hospitalization and rehospitalization, and die prematurely. The primary mode of therapy for this syndrome is based on antagonism of neurohormonal pathways (notably, the sympathetic nervous system2 and the renin–angiotensin–aldosterone axis3,4) activated in the failing cardiovascular system. Drugs that antagonize these pathways decrease mortality and morbidity24 and in some cases improve the underlying structural abnormalities of the heart, a process termed “reverse remodeling.”5 On the basis of . . .
Supplementary Figure 11 from <i>Helicobacter pylori</i> Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway <i>In vitro</i> and <i>In vivo</i> (2023)

Supplementary Figure 11 from &lt;i&gt;Helicobacter pylori&lt;/i&gt; Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt;
Real-Time Mitigation of Short-Range Leakage in Automotive FMCW Radar Transceivers (2016)

Frequency-modulated continuous wave radar systems suffer from permanent leakage of the transmit signal into the receive path. Besides leakage within the radar device itself, an unwanted object placed in front of the antennas causes so-called short-range (SR) leakage. In an automotive application, for instance, it originates from signal reflections of the car's own bumper. Particularly the residual phase noise of the downconverted SR leakage signal causes a severe degradation of the achievable sensitivity. In an earlier work, we proposed an SR leakage cancellation concept that is feasible for integration in a monolithic microwave integrated circuit. In this brief, we present a hardware prototype that holistically proves our concept with discrete components. The fundamental theory and properties of the concept are proven with measurements. Further, we propose a digital design for real-time operation of the cancellation algorithm on a field programmable gate array. Ultimately, by employing measurements with a bumper mounted in front of the antennas, we show that the leakage canceller significantly improves the sensitivity of the radar.
69.2: Laser‐Microstructuring of Cathodes for OLED‐Displays (2005)

Abstract We introduce an innovative approach for structuring the metal cathode of passive matrix OLED displays based on laser ablation of the thin metal film. Laser patterned displays are presented and compared to conventional photolithographically processed devices with regard to their LIV‐characteristic and rectification ratio.