gebhart/patrepeval huggingface dataset:
Meeting Report (2010)

The Translational Research Cancer Centers Consortium (TrC3) is a cancer immunotherapy network, established to promote biologic therapeutics in the Midwestern and Northeastern regions of The United States. The 13th Annual Meeting of the TrC3 was hosted by The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and took place at The Blackwell Hotel and Conference Center in Columbus, OH on March 1-2, 2010 (http://www.osuccc.osu.edu/TrC3/index.htm). This year's theme was "Immune Suppression and the Tumor Microenvironment." The meeting consisted of 21 oral presentations, a roundtable discussion focused on enhancing collaborative relationships within the consortium, and a poster session with 54 abstracts from predoctoral or postdoctoral researchers. This annual meeting brought together more than 170 investigators from 9 regional cancer centers including: Abramson Cancer Center at The University of Pennsylvania, Barbara Ann Karmanos Cancer Institute at Wayne State University, Case Comprehensive Cancer Center, Cleveland Clinic Taussig Cancer Center, James P. Wilmot Cancer Center, Mary Babb Randolph Cancer Center at West Virginia University, The Ohio State University Comprehensive Cancer Center, Penn State Cancer Institute, Roswell Park Cancer Institute, and University of Pittsburgh Cancer Institute. The proceedings of this year's meeting are summarized in this report.
Polytope Sector-Based Synthesis and Analysis of Microstructural Architectures With Tunable Thermal Conductivity and Expansion (2016)

The aim of this paper is to (1) introduce an approach, called polytope sector-based synthesis (PSS), for synthesizing 2D or 3D microstructural architectures that exhibit a desired bulk-property directionality (e.g., isotropic, cubic, orthotropic, etc.), and (2) provide general analytical methods that can be used to rapidly optimize the geometric parameters of these architectures such that they achieve a desired combination of bulk thermal conductivity and thermal expansion properties. Although the methods introduced can be applied to general beam-based microstructural architectures, we demonstrate their utility in the context of an architecture that can be tuned to achieve a large range of extreme thermal expansion coefficients—positive, zero, and negative. The material-property-combination region that can be achieved by this architecture is determined within an Ashby-material-property plot of thermal expansion versus thermal conductivity using the analytical methods introduced. These methods are verified using finite-element analysis (FEA) and both 2D and 3D versions of the design have been fabricated using projection microstereolithography.
Vascular characterization of mice with endothelial expression of cytochrome P450 4F2 (2014)

Cytochrome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Although CYP4A-derived 20-HETE is known to have prohypertensive and proangiogenic properties, the effects of CYP4F-derived metabolites are not well characterized. To investigate the role of CYP4F2 in vascular disease, we generated mice with endothelial expression of human CYP4F2 (Tie2-CYP4F2-Tr). LC/MS/MS analysis revealed 2-foldincreases in 20-HETE levels in tissues and endothelial cells (ECs), relative to wild-type (WT) controls. Tie2-CYP4F2-Tr ECs demonstrated increases in growth (267.1 ± 33.4 vs. 205.0 ± 13% at 48 h) and tube formation (7.7 ± 1.1 vs. 1.6 ± 0.5 tubes/field) that were 20-HETE dependent and associated with up-regulation of prooxidant NADPH oxidase and proangiogenic VEGF. Increases in VEGF and NADPH oxidase levels were abrogated by inhibitors of NADPH oxidase and MAPK, respectively, suggesting the possibility of crosstalk between pathways. Interestingly, IL-6 levels in Tie2-CYP4F2-Tr mice (18.6 ± 2.7 vs. 7.9 ± 2.7 pg/ml) were up-regulated via NADPH oxidase- and 20-HETE-dependent mechanisms. Although Tie2-CYP4F2-Tr aortas displayed increased vasoconstriction, vasorelaxation and blood pressure were unchanged. Our findings indicate that human CYP4F2 significantly increases 20-HETE production, CYP4F2-derived 20-HETE mediates EC proliferation and angiogenesis via VEGF- and NADPH oxidase-dependent manners, and the Tie2-CYP4F2-Tr mouse is a novel model for examining the pathophysiological effects of CYP4F2-derived 20-HETE in the vasculature.-Cheng, J., Edin, M. L., Hoopes, S. L., Li, H., Bradbury, J. A., Graves, J. P., DeGraff, L. M., Lih, F. B., Garcia, V., Shaik, J. S. B., Tomer, K. B., Flake, G. P., Falck, J. R., Lee, C. R., Poloyac, S. M., Schwartzman, M. L., Zeldin, D. C. Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.
Assessing QT-RR interval hysteresis in 12-lead electrocardiograms (2009)

The amount of QT-RR interval hysteresis accumulated during the load and recovery phases of exercise stress test reflects the degree of exercise induced myocardial ischemia. Therefore the evaluation of hysteresis from 12-lead ECG (12-SL) is an important practical modality for the assessment of severity of coronary artery disease. Commercial QT and RR waveform analyzers are regularly subjected to interval detection artifacts which prevent reliable estimation for the magnitude of QT-RR hysteresis in one or multiple leads. We present a new signal processing technique which overcomes this deficiency. It quantifies the level of faulty interval measurements and using a threshold eliminates the need to process potentially corrupt leads.
Sustained Gonadotropin-Releasing Hormone Stimulation Mobilizes the cAMP/PKA Pathway to Induce Nitric Oxide Synthase Type 1 Expression in Rat Pituitary Cells In Vitro and In Vivo at Proestrus1 (2010)

Previous in vivo studies have established that pituitary nitric oxide synthase type 1 (NOS1) is regulated by gonadotropin-releasing hormone (GnRH). The aim of our study was to elucidate the mechanisms of NOS1 regulation by GnRH in rat pituitary cells. Using a perifused cell system, we demonstrated that NOS1 induction was sensitive to GnRH pulse frequency and was maximally induced under continuous GnRH stimulation. In primary cultures of rat pituitary cells, sustained stimulation with the GnRH agonist triptorelin (GnRHa) increased NOS1 protein levels, whereas NOS2 and NOS3 levels were unaffected. NOS1 up-regulation occurred in gonadotroph cells only, in a time-dependent and concentration-dependent manner (maximum increase, 2.5-fold; half-maximal concentration, 0.17 nM). GnRHa effect was mimicked by cAMP pathway activators and, most importantly, was blocked by disruption of the protein kinase A (PKA) pathway using pharmacological inhibitors such as Rp-cAMP or drug phosphatase technology-protein kinase inhibitor (DPT-PKI), a cell-permeant PKI peptide. In contrast, modulation of the PKC pathway and inhibition of the MAPK cascade were ineffective. Overall, these experiments demonstrated that GnRH-induced up-regulation of pituitary NOS1 is mediated notably by the cAMP/PKA pathway. Last, in vivo administration of a GnRH antagonist markedly inhibited the pituitary cAMP rise at proestrus in addition to suppressing NOS1 increase. Altogether, our data suggest that the cAMP/PKA signaling pathway is preferentially recruited under sustained GnRH stimulation in vivo during proestrus, allowing the expression of a specific set of PKA-regulated proteins, including NOS1, in gonadotroph cells.
Adaptive Control of Robot Manipulators in Constrained Motion—Controller Design (1995)

Adaptive motion and force control of manipulators in constrained motion in the presence of parametric uncertainties both in the robot and contact surfaces are considered in this paper. A new constrained dynamic model is obtained to account for the effect of contact surface friction. An adaptive law is suggested with unknown parameters updated by both the motion and force tracking errors to guarantee asymptotic motion and force tracking without any persistent excitation conditions to be satisfied. The suggested controller has the expected PI type force feedback control structure with a low proportional (P) force feedback gain. Detailed simulation results are given to show the effectiveness of the proposed controller.
Reductive Cyclization of Ketones Tethered to Activated Olefins Mediated by Magnesium in Methanol (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive Cyclization of Ketones Tethered to Activated Olefins Mediated by Magnesium in MethanolGe Hyeong Lee, Eun Bok Choi, Eun Lee, and Chwang Siek PakCite this: J. Org. Chem. 1994, 59, 6, 1428–1443Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://doi.org/10.1021/jo00085a036RIGHTS & PERMISSIONSArticle Views1457Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A stacked array antenna able to make a very large gain and tilt the end‐fire beam at the ISM‐band (2019)

In this article, an antenna is designed to generate an end-fire radiated beam of a very large gain for a Printed Circuit Board (PCB) structure and steer the beam at an Industrial Scientific Medical (ISM)-band. A flush-mounted slot-coupled feed and two parasitic layers can increase the antenna gain substantially. This single element is made to be a 1-by-8 array to generate a very high gain to deliver wireless power more than single element to the far-field zone and spot the receiver of interest without interference toward others on the azimuth plane. Furthermore, four layers of this array are stacked to tilt the beam up and down on the elevation plane for target selectivity of a higher degree and more wireless-power transfer. The antenna system is implemented with the substrate of Rogers 4350B and operated at 2.4 GHz as the ISM-band service, and the validity of the proposed design is verified by electromagnetic numerical simulation and physical realization. The simulation and measurement of the fabricated 1D array antenna show nearly 19 and 16 dBi, respectively as high gains. The stacked structure as a 2D array generate the titled beam moving from −35° to 35° with the antenna gain from 17 to 20 dBi for a varying angle.
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors (2021)

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol. We then found that both typical and fast-acting antidepressants directly bind to TRKB, thereby facilitating synaptic localization of TRKB and its activation by BDNF. Extensive computational approaches including atomistic molecular dynamics simulations revealed a binding site at the transmembrane region of TRKB dimers. Mutation of the TRKB antidepressant-binding motif impaired cellular, behavioral, and plasticity-promoting responses to antidepressants in vitro and in vivo. We suggest that binding to TRKB and allosteric facilitation of BDNF signaling is the common mechanism for antidepressant action, which may explain why typical antidepressants act slowly and how molecular effects of antidepressants are translated into clinical mood recovery.
Table S2 from Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer (2023)

&lt;p&gt;APM mutation and copy number alterations&lt;/p&gt;
Drawing of ultrahigh molecular weight polyethylene fibers in the presence of supercritical carbon dioxide (2003)

Abstract The drawing behavior of ultrahigh molecular weight polyethylene fibers in supercritical carbon dioxide (scCO 2 ) is compared to that in air at different temperatures. The temperature substantially influences the drawing properties in air, whereas in scCO 2 , a constant draw stress and tensile strength are observed. Differential scanning calorimetry shows an apparent development of a hexagonal phase along with a significant increase in the crystallinity of air‐drawn samples with increasing temperature. The existence of this phase is not confirmed by wide‐angle X‐ray scattering, which instead shows that air‐drawn samples crystallize in an internally constrained manner. In contrast, scCO 2 allows crystals to grow without constraints through a possible crystal–crystal transformation, increasing the processing temperature to 110 °C. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 1375–1383, 2003
Perceptual video quality assessment in HTTP adaptive streaming (2015)

In this paper, we propose a quality metric for video transmitted over HTTP adaptive streaming (HAS). Perceived video quality in HAS strongly depends on the employed rate adaptation mechanisms, transmission conditions and buffer filling levels. Predicting perceived quality in HAS is an open problem, due to the lack of appropriateness of existing metrics. To overcome this problem, a quality metric based on extensive user evaluations is proposed in this paper. A thorough investigation is carried out, accounting for all possible types of video quality impairments occurring in HAS applications. The proposed metric correlates well with the perceived quality, allowing for optimizing the HAS descriptions and of the switching mechanism between them. It is also shown that the classical intrinsic quality metrics (PSNR, SSIM, VQM) fail to predict user-perceived video quality due to quality fluctuations inherent to HAS systems.
A general framework of synthesizing 129Xe MRI data for improved segmentation model training (2023)

Quantitative analysis of hyperpolarized 129 Xe MRI, segmentation of the thoracic cavity, a crucial step that is often the bottleneck in an otherwise fully automated pipeline. This problem is attractive to solve using deep learning methods, but they are limited by their large appetite for manually segmented training data. To this end, we propose a method to automatically synthesize both 129 Xe ventilation MR images and their corresponding thoracic cavity masks using general adversarial networks. This data augmentation technique can accelerate the training of deep learning segmentation models.
Phytate levels in diverse rat tissues: influence of dietary phytate (2001)

Phytate (inositol hexaphosphate; InsP6) was determined in rat tissues fed on diets with different phytate contents, using a GC-mass detection methodology that permitted the evaluation of the total amount of this substance present in such tissues. The highest InsP6 concentrations were found in brain 5.89 x 10(-2)(SE 5.7 x 10(-3)) mg/g DM), whereas the concentrations detected in kidneys, liver and bone were similar to each other 1.96 x 10(-3) (SE 0.20 x 10(-3), 3.11 x 10(-3) (SE 0.24 x 10(-3), 1.77 x 10(-3) (SE 0.17 x 10(-3)) mg/g DM respectively) and 10-fold less than those detected in brain. When rats were fed on a purified diet in which InsP6 was undetectable, the InsP6 levels of the organs mentioned earlier decreased dramatically (9.0 x 10(-4), 3.8 x 10(-5), 1.4 x 10(-5) mg/g DM in brain, kidneys and liver respectively) and in some cases became undetectable (bone). The addition of InsP6 to this purified diet led to the increase of InsP6 levels in these tissues. This clearly demonstrated that the majority of the InsP6 found in organs and tissues has a dietary origin and is not a consequence of endogenous synthesis. Consequently, considering that InsP6 could be involved in some important biological roles, the value of any diet on supplying this substance is noteworthy.
Load sharing in hypercube-connected multicomputers in the presence of node failures (1996)

The paper addresses two important issues associated with load sharing (LS) in hypercube-connected multicomputers: (1) ordering fault-free nodes as preferred receivers of "overflow" tasks for each overloaded node and (2) developing an LS mechanism to handle node failures. Nodes are arranged into preferred lists of receivers of overflow tasks in such a way that each node will be selected as the kth preferred node of one and only one other node. Such lists are proven to allow the overflow tasks to be evenly distributed throughout the entire system. However, the occurrence of node failures will destroy the original structure of a preferred list if the failed nodes are simply dropped from the list, thus forcing some nodes to be selected as the kth preferred node of more than one other node. The authors propose three algorithms to modify the preferred list such that its original features can be retained regardless of the number of faulty nodes in the system. It is shown that the number of adjustments or the communication overhead of these algorithms is minimal. Using the modified preferred lists, they also proposed a simple mechanism to tolerate node failures. Each node is equipped with a backup queue which stores and updates the information on the tasks arriving/completing at its most preferred node.
T-Jump/Time-of-Flight Mass Spectrometery for Time Resolved Analysis of Fast Condensed Stated Reactions (2009)

We describe a new T-jump/time-of-flight mass spectrometer for timeresolved analysis of rapid pyrolysis chemistry of solids and liquids, with a focus on energetic materials. The instrument employs a thin wire substrate which can be coated with the material of interest, and can be rapidly heated (~10 6 K/s). The T-Jump probe is inserted with the extraction region of a linear-TOF mass spectrometer, which enables multiple spectra to be obtained during a single reaction event. By monitoring the electrical characteristics of the heated wire, the temperature can also be obtained and correlated to the mass-spectra. As an example, we present time-resolved spectra for the ignition of RDX and nanocomposite thermites. The fidelity of the instrument is demonstrated in the spectra presented which show the temporal formation and decay of several species in both systems. A simultaneous measurement of temperature enables us to extract the ignition temperature and the characteristic reaction time. The obtained time resolved mass spectra show that these solid energetic material reactions, under a rapid heating rate, can occur on a time scale of milliseconds or less. The capability of high speed time resolved measurements offers an additional analytical tool for characterization of the decomposition, ignition, and combustion of energetic materials
Resonant coupling between a subwavelength metal patch perfect absorbing metamaterial and molecular resonance (2016)

Coupling between vibrational modes and metamaterial structures has a varied range of applications including, but not limited to, surface-enhanced vibrational spectroscopy and biological sensing. This endeavor investigates, via finite element method (FEM) and temporal coupled mode theory (TCMT), a subwavelength perfect absorbing metamaterial (PAMM) coupling to a carbon double oxygen bond (C=O) in Poly(methyl methacrylate) (PMMA) that resides at 52 THz or 1733 cm−1.
Intramolecural Photocycloaddition on Dioxolenones: An Efficient Method for the Synthesis of Medium-sized Rings (1987)

The intramolecular photocycloaddition of dioxolenones to simple olefins leads to the formation of sir-, seven-, and eight-membered rings in good yields.Asymmetric induction in the formation of cyclooetanes is described.The extension of the de Elayo to the ends of 0-ketoesters could significantly expand the utility of this reaction in synthesis, since the regioselective functionalization, i.e., alkylation and enolization, of the ketoesters is more straightforward than the same transformations in the 0-diketone Baldwln haa reported that dioxolenones, which can be regarded as the covalently restricted cis eool tautomers of the corresponding ketoesters, undergo intermolecular [2+2]-photochemical cycloaddition with alkenes, although with regiochemical outcomes which are difficult to predict.''We report herein that the intramolecular photoaddition of dioxolenones to alkenes results in the formation of six-, aeven-, and eight-membered rings, i.e, 1-3, in good yields with excellent regiochemical control.Scheme I
The Massachusetts LEAP network: building a template for a hands-on advanced manufacturing hub in integrated photonics (Conference Presentation) (2022)

MassTech Collaborative has helped to make the Commonwealth of Massachusetts a beacon for advanced manufacturing. In partnership with the AIM Photonics manufacturing institute, MassTech has launched five Laboratories for Education and Application Prototypes (LEAPs) within academic institutions spread widely across Massachusetts, to develop a skilled workforce in integrated photonics. Hands-on and in-person workshops, bootcamps and laboratory courses are offered at these LEAPs to learners from academia, industry, and the government. The MA LEAP network stands as an excellent self-sustaining model for hands-on STEM education and workforce training for the rest of the country.
Local tuning of photonic crystal cavities using chalcogenide glasses (2008)

We developed a method to locally tune refractive index in photonic crystals. The technique, based on photodarkening of chalcogenide glasses, enables 3nm resonance tuning of GaAs photonic crystal cavities operating at 940nm.
Supplementary Figure Legends 1-2 from Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells (2023)

Supplementary Figure Legends 1-2 from Pyridone 6, A Pan-Janus–Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells
Performance bounds for sparse signal reconstruction with multiple side information [arXiv] (2016)

In the context of compressive sensing (CS), this paper considers the problem of reconstructing sparse signals with the aid of other given correlated sources as multiple side information (SI). To address this problem, we propose a reconstruction algorithm with multiple SI (RAMSI) that solves a general weighted n-ℓ1 norm minimization. The proposed RAMSI algorithm takes advantage of both CS and the n-ℓ1 minimization by adaptively computing optimal weights among SI signals at every reconstructed iteration. In addition, we establish theoretical performance bounds on the number of measurements that are required to successfully reconstruct the original sparse source using RAMSI under arbitrary support SI conditions. The analyses of the established bounds reveal that RAMSI can achieve sharper bounds and significant performance improvements compared to classical CS. We evaluate experimentally the proposed algorithm and the established bounds using synthetic sparse signals as well as correlated feature histograms, extracted from a multiview image database for object recognition. The obtained results show clearly that the proposed RAMSI algorithm outperforms classical CS and CS with single SI in terms of both the theoretical bounds and the practical performance.