gebhart/patrepeval huggingface dataset:
Correction to “Origin of Electrochromism in High-Performing Nanocomposite Nickel Oxide” (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Origin of Electrochromism in High-Performing Nanocomposite Nickel Oxide"Feng Lin, Dennis Nordlund, Tsu-Chien Weng, Dimosthenis Sokaras, Kim M. Jones, Rob B. Reed, Dane T. Gillaspie, Douglas G. J. Weir, Rob G. Moore, Anne C. Dillon, Ryan M. Richards, and Chaiwat Engtrakul*Cite this: ACS Appl. Mater. Interfaces 2013, 5, 17, 8820Publication Date (Web):August 30, 2013Publication History Published online30 August 2013Published inissue 11 September 2013https://pubs.acs.org/doi/10.1021/am4027554https://doi.org/10.1021/am4027554correctionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views585Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (110 KB) Get e-Alertsclose Get e-Alerts
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006)

Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of activities represents one important form of cell polarity. There are significant gaps in our understanding of the components involved in generating and maintaining polarity during chemotaxis. Here we characterize a family of complexes (which we term leading edge complexes), scaffolded by hematopoietic protein 1 (Hem-1), that organize the neutrophil's leading edge. The Wiskott-Aldrich syndrome protein family Verprolin-homologous protein (WAVE)2 complex, which mediates activation of actin polymerization by Rac, is only one member of this family. A subset of these leading edge complexes are biochemically separable from the WAVE2 complex and contain a diverse set of potential polarity-regulating proteins. RNA interference-mediated knockdown of Hem-1-containing complexes in neutrophil-like cells: (a) dramatically impairs attractant-induced actin polymerization, polarity, and chemotaxis; (b) substantially weakens Rac activation and phosphatidylinositol-(3,4,5)-tris-phosphate production, disrupting the (phosphatidylinositol-(3,4,5)-tris-phosphate)/Rac/F-actin-mediated feedback circuit that organizes the leading edge; and (c) prevents exclusion of activated myosin from the leading edge, perhaps by misregulating leading edge complexes that contain inhibitors of the Rho-actomyosin pathway. Taken together, these observations show that versatile Hem-1-containing complexes coordinate diverse regulatory signals at the leading edge of polarized neutrophils, including but not confined to those involving WAVE2-dependent actin polymerization.
ASSOCIATION OF D3 RECEPTOR GENE POLYMORPHISM WITH SCHIZOPHRENIA (1992)

Crocq, M - A; Lannfelt, L; Sokoloff, P; Mayer, A; Martres, M-P; Schwartz, J-C; Hode, Y; Duval, F; Macher, J-P Author Information
Utility Max-Min Fair Resource Allocation for Diversified Applications in EPON (2012)

In EPONs, differentiated services enable higher quality of service (QoS) for some queues over others. However, owing to the coarse granularity of DiffServ, DiffServ in EPONs can hardly facilitate any particular QoS profile. This paper investigates an application-oriented bandwidth allocation scheme to ensure fairness among queues with diversified QoS requirements. We first define application utilities to quantify users’ quality of experience (QoE) as a function of network layer QoS metrics. We then formulate the fair resource allocation issue into a max-min utility problem, which is quasi-concave over queues’ delayed traffic and dropped traffic. We further employ the bisection method to obtain the optimal solution of the quasi-concave maximization problem. The optimal value can be achieved by proper bandwidth allocation and queue management schemes in EPONs.
Late Breaking Abstract - Automated coaching for physical activity in COPD patients: results from a pilot study (2017)

Physical activity (PA) is important for COPD patients, however it is difficult to increase and maintain. An automated coaching program, based on self-regulation and objective PA data, has been recently developed (Van Genugten L. et al, 2016). The aim of this pilot study was to evaluate if this web-based intervention can increase PA in COPD patients. In this RCT 21 patients were recruited and wore an activity monitor (DirectLife, Philips) throughout the study. PA was assessed as the number of minutes per day spent in moderate intensity, termed as <i>ActivePoints</i> (AP). After a 2-week baseline period, patients were randomized to the intervention (IG) or control (CG) group for 2 months. IG received automated coaching, based on PA, with weekly goals, daily feedback and coaching messages. CG was blinded to their PA and not exposed to any intervention. Ten IG (age 69.8±8.1y; FEV1%pred 44.3±14.3) and 8 CG (age 67.7±4.5y; FEV1%pred 42.5±11.5) patients completed the study. Baseline PA was comparable in the two groups (CG: 264.1±204.9 AP; IG: 241.0±126.6 AP, p=0.77). IG visited the coaching website 87.3±14.5% of days. Between start and end of the study, the % difference in PA was higher in IG patients than CG (19.6±28.7% and -12.2±21.9 respectively; p=0.014. Figure 1). This pilot study suggests that this coaching system is effective in increasing PA at home in patients with COPD. Further data are required to reinforce these promising results.
POS experiments in the MHD and EMH regimes (1995)

Summary form only given, as follows. Plasma dynamics are characterized in a long-conduction-time planar plasma opening switch (POS) using measurements of the magnetic field and electron density. In the first set of experiments, the POS is operated near the theoretical intersection of the predicted MHD and EMH regimes. In qualitative agreement with MHD theory, a hydrodynamic snowplow is observed to translate axially down the switch and reach the load end at the start of the opening phase. Theory modifications to include ion losses bring the plasma dynamics into quantitative agreement with MHD theory. In the second set of experiments, the POS is operated in a regime where EMH effects are expected to control the switch conduction. For the measured electron density minimum in the radial center of the switch, magnetic field convection into the plasma is predicted near the anode with expulsion near the cathode. In conflict with the model, measurements show extensive field penetration across the switch, with broad, predominantly radial, current channels. To further isolate possible EMH effects, the switch polarity was reversed. Measurements again show broad, predominantly radial, current channels similar to those measured with the original polarity. The measurements indicate that while some effects are present that may be attributable to EMH, the conduction phase of the POS operated in this regime is controlled by other processes.
Figure S1 and S2 from TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma (2023)

&lt;p&gt;Supplementary Figures and Legends&lt;/p&gt;
AptaTRACE: Elucidating Sequence-Structure Binding Motifs by Uncovering\n Selection Trends in HT-SELEX Experiments (2016)

Aptamers, short synthetic RNA/DNA molecules binding specific targets with\nhigh affinity and specificity, are utilized in an increasing spectrum of\nbio-medical applications. Aptamers are identified in vitro via the Systematic\nEvolution of Ligands by Exponential Enrichment (SELEX) protocol. SELEX selects\nbinders through an iterative process that, starting from a pool of random\nssDNA/RNA sequences, amplifies target-affine species through a series of\nselection cycles. HT-SELEX, which combines SELEX with high throughput\nsequencing, has recently transformed aptamer development and has opened the\nfield to even more applications. HT-SELEX is capable of generating over half a\nbillion data points, challenging computational scientists with the task of\nidentifying aptamer properties such as sequence structure motifs that determine\nbinding. While currently available motif finding approaches suggest partial\nsolutions to this question, none possess the generality or scalability required\nfor HT-SELEX data, and they do not take advantage of important properties of\nthe experimental procedure.\n We present AptaTRACE, a novel approach for the identification of\nsequence-structure binding motifs in HT-SELEX derived aptamers. Our approach\nleverages the experimental design of the SELEX protocol and identifies\nsequence-structure motifs that show a signature of selection. Because of its\nunique approach, AptaTRACE can uncover motifs even when these are present in\nonly a minuscule fraction of the pool. Due to these features, our method can\nhelp to reduce the number of selection cycles required to produce aptamers with\nthe desired properties, thus reducing cost and time of this rather expensive\nprocedure. The performance of the method on simulated and real data indicates\nthat AptaTRACE can detect sequence-structure motifs even in highly challenging\ndata.\n
Hydrogen Evolution from Water under Visible-Light Irradiation Using Keggin-Type Platinum(II)-Coordinated Phospho-, Silico-, and Germanotungstates as Co-Catalysts (2016)

The tetramethylammonium salts of diplatinum(II) complexes composed of mono-lacunary Keggin-type silico and germanotungstates, [(CH3)4N]4[α-SiW11O39{cis-Pt(NH3)2}2]·13H2O (TMA-Si-Pt) and [(CH3)4N]4[α-GeW11O39{cis-Pt(NH3)2}2]·11H2O (TMA-Ge-Pt), were synthesized and crystallized. Single crystals of a tetramethylammonium salt of Keggin-type diplatinum(II)-coordinated phosphotungstate [(CH3)4N]3[α-PW11O39{cis-Pt(NH3)2}2]×10H2O (TMA-P-Pt) were also obtained. The X-ray structural analyses revealed that the two cis-platinum(II) moieties, [cis-Pt(NH3)2]2+, were each coordinated to two oxygen atoms in a mono-vacant site of [XW11O39](12-n)- (Xn+ = Si4+, Ge4+, P5+). FTIR spectra of TMA-Si-Pt and TMA-Ge-Pt also suggested that the two platinum(II) moieties were coordinated to the vacant site of [SiW11O39]8- and [GeW11O39]8-. The 1H NMR spectra in DMSO-d6 of TMA-Si-Pt and TMA-Ge-Pt showed signals assigned to the two sets of NH3 ligands coordinated to the platinum sites. These three platinum compounds showed hydrogen evolution from aqueous triethanolamine solution under visible light irradiation (λ ≥ 400 nm) in the presence of eosin Y, α-Keggin mono-aluminum-substituted silicotungstate, and titanium dioxide. The catalytic activities were influenced by the central atoms, and TMA-P-Pt showed the highest activities among the three platinum compounds.
Novel method for measurement of fatigue in multiple sclerosis: Real-Time Digital Fatigue Score (2010)

The study's objective was to develop a real-time measurement for fatigue and to evaluate whether it is an effective clinical trial outcome measure compared with the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS). Forty-nine subjects with MS and an FSS >4 recorded Real-Time Digital Fatigue Scores (RDFSs) on a wrist-worn device four times a day over 3 weeks. Scores were scaled 0-10, with 10 representing the worst possible fatigue. FSS and MFIS were evaluated and compared with RDFSs. Mean RDFSs significantly correlated with FSS (r = 0.55, p < 0.001) and MFIS (r = 0.55, p < 0.001). RDFS captured circadian variations in fatigue, with scores increasing from mean 3.4 at 9 a.m., to 4.0 at 1 p.m., 4.5 at 5 p.m., and 5.0 at 9 p.m. When all scores over all days were included in a mixed-model analysis of circadian variation, the differences in RDFS between times were more significant than in an analysis that included only single scores of data isolated from the first day of monitoring. RDFS is a promising measure. RDFS significantly correlated with FSS and MFIS, captured real-time daily and circadian variations in fatigue, and provided multiple measurements of fatigue that provided statistical advantages over FSS and MFIS.
Effect of Sodium Selenite on Antioxidative Enzymes of Banana Fruitfly (1989)

The median and maximum life spans of Zaprionus paravittiger are 43 and 79 days, respectively, for males and 52 and 91 days for females at 24 +/- 2 degrees C. Sodium selenite (SS), an antioxidant, feeding prolongs the median as well as maximum life span of both the sexes. Antioxidative enzymes, catalase and peroxidase showed greater activity during the developmental stages. Females, at most of the age intervals, exhibited greater enzymatic activities as compared to their age-matched males. Both the sexes showed a statistically significant increase in the baseline activity of these enzymes as consequent upon SS feeding. It is suggested that SS acts by strengthening the antioxidative enzymes, namely catalase and peroxidase.
Use the power of sonocrystallization for improved properties (2001)

High-intensity sound initiates nucleation and helps to control crystal size and habit to yield products that better meet users' specifications.
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin (2017)

Growth factors, such as insulin, can induce both acute and long-term glucose uptake into cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT)4 storage vesicles with the cell surface that occurs in muscle and adipose tissues, the mechanism behind acute induction has been unclear in other systems. Thioredoxin interacting protein (TXNIP) has been shown to be a negative regulator of cellular glucose uptake. TXNIP is transcriptionally induced by glucose and reduces glucose influx by promoting GLUT1 endocytosis. Here, we report that TXNIP is a direct substrate of protein kinase B (AKT) and is responsible for mediating AKT-dependent acute glucose influx after growth factor stimulation. Furthermore, TXNIP functions as an adaptor for the basal endocytosis of GLUT4 in vivo, its absence allows excess glucose uptake in muscle and adipose tissues, causing hypoglycemia during fasting. Altogether, TXNIP serves as a key node of signal regulation and response for modulating glucose influx through GLUT1 and GLUT4.
Suppurative cholangitis induced by a fully covered self-expandable metal stent covering cystic stumps in a post-liver transplant patient (2013)

cholangitis induced by a fully covered self-expandable metal stent
Different surgical options for monocompartmental osteoarthritis of the knee: high tibial osteotomy versus unicompartmental knee arthroplasty versus total knee arthroplasty: indications, techniques, results, and controversies. (2004)

The decision of what procedure to perform for the treatment of monocompartmental osteoarthritis of the knee when nonsurgical treatment methods fail remains controversial. Recent advances using osteotomy, unicompartmental knee replacement, and total knee replacement have been reported. For example, there are new concepts for performing high tibial osteotomies rather than the traditional Coventry method. Many techniques now involve osteotomies below the tibial tubercle. Unicompartmental knee replacement can be done using a standard approach, but less invasive approaches exist, along with minimally invasive approaches for total knee replacement, rather than the standard large incision, that promote decreased soft-tissue destruction.
Comment re: Ran-GTP Control of Tumor Cell Mitosis (2009)

In Response:We thank Simula and colleagues for commenting on our recent article (1), and for reporting their findings of increased Ran expression in a group of patients with histopathologic features of destructive celiac disease. Although it will be necessary to confirm these results in a much larger patient population, the idea that Ran up-regulation may occur in epithelial cells chronically exposed to inflammatory conditions, and prone to full-blown malignant transformation, is generally in keeping with our own conclusions (1), identifying Ran as a mediator of aberrant cell division, potentially contributing to aneuploidy and genomic instability. However, it is important to caution against premature generalization from the initial observations of Simula and colleagues. In particular, our results, along with the data of a follow up study (2), emphasize that increased expression not only of Ran, but also of Ran-GTP effector molecules, for instance survivin, is critical to globally exploit this pathway for deregulated cell division. It is not inconceivable that survivin or other Ran-GTP effector molecules, for instance Aurora A or TPX2, may also become up-regulated during chronic inflammatory responses, in vivo. However, in the absence of these data, a potential causative role of Ran in mediating aberrant cell division during the evolution of celiac disease remains experimentally unproven.No potential conflicts of interest were disclosed.
Iterative Signal Processing for Mitigation of Analog‐to‐Digital Converter Clipping Distortion in Multiband OFDMA Receivers (2012)

In modern wideband communication receivers, the large input‐signal dynamics is a fundamental problem. Unintentional signal clipping occurs, if the receiver front‐end with the analog‐to‐digital interface cannot respond to rapidly varying conditions. This paper discusses digital postprocessing compensation of such unintentional clipping in multiband OFDMA receivers. The proposed method iteratively mitigates the clipping distortion by exploiting the symbol decisions. The performance of the proposed method is illustrated with various computer simulations and also verified by concrete laboratory measurements with commercially available analog‐to‐digital hardware. It is shown that the clipping compensation algorithm implemented in a turbo decoding OFDM receiver is able to remove almost all the clipping distortion even under significant clipping in fading channel circumstances. That is to say, it is possible to nearly recover the receiver performance to the level, which would be achieved in the equivalent nonclipped situation.
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2receptor (2009)

Background and purpose: The OX2 receptor is a G-protein-coupled receptor that is abundantly found in the tuberomammillary nucleus, an important site for the regulation of the sleep-wake state. Herein, we describe the in vitro and in vivo properties of a selective OX2 receptor antagonist, N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA). Experimental approach: The affinity of [3H]EMPA was assessed in membranes from HEK293-hOX2-cells using saturation and binding kinetics. The antagonist properties of EMPA were determined by Schild analysis using the orexin-A- or orexin-B-induced accumulation of [3H]inositol phosphates (IP). Quantitative autoradiography was used to determine the distribution and abundance of OX2 receptors in rat brain. The in vivo activity of EMPA was assessed by reversal of [Ala11,D-Leu15]orexin-B-induced hyperlocomotion during the resting phase in mice and the reduction of spontaneous locomotor activity (LMA) during the active phase in rats. Key results: [3H]EMPA bound to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nmol·L−1 respectively. EMPA competitively antagonized orexin-A- and orexin-B-evoked accumulation of [3H]IP at hOX2 receptors with pA2 values of 8.6 and 8.8 respectively. Autoradiography of rat brain confirmed the selectivity of [3H]EMPA for OX2 receptors. EMPA significantly reversed [Ala11,D-Leu15]orexin-B-induced hyperlocomotion dose-dependently during the resting phase in mice. EMPA, injected i.p. in rats during the active phase, reduced LMA dose-dependently. EMPA did not impair performance of rats in the rotarod procedure. Conclusions and implications: EMPA is a high-affinity, reversible and selective OX2 receptor antagonist, active in vivo, which should prove useful for analysis of OX2 receptor function.
Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism (1986)

Behaviorally impaired old rats were selected from a population of 75 21- to 23-month-old rats on the basis of the place-investigated abilities in the Morris' water-maze task. After the pretransplant test, half of the old impaired rats received bilateral intrahippocampal cell suspension grafts prepared from the fetal septal-diagonal band region, which is rich in developing cholinergic neurons; the other half were left as sham-operated controls. Twelve weeks after grafting, the rats were retested in the water-maze using alternating cue-navigation and place-navigation trials (i.e., with visible or nonvisible escape platform). While the old impaired controls had deteriorated further between the 2 tests and showed poor retention of the pretransplant performance level, the grafted rats were significantly improved in comparison with both their pretransplant performance and the performance of the old impaired controls in the posttransplant test. The graft-induced effect was due both to an improved retention of the performance level acquired in the test performed prior to transplantation surgery, and to an improved acquisition of spatial memory of the escape platform site during the posttransplant test week (measured as an improved focusing of search over the platform site after platform removal). The acetylcholine esterase inhibitor physostigmine had no or only marginal effects on the performance of any of the young or aged rat groups. By contrast, the recovered navigational abilities and spatial memory in the grafted animals were completely abolished after administration of the muscarinic receptor antagonist atropine. A similar atropine-sensitivity was seen in behaviorally nonimpaired aged rats but not in the well-trained young control rats. The results show that cholinergic septal grafts, implanted into the hippocampal formation, improved spatial learning in the impaired aged rats primarily, or perhaps exclusively, by a recovery of the rats' ability to use spatial cues for place-navigation in the water-maze, while other aspects of the performance deficits in the water-maze task in the aged rats were left unaffected by the septal grafts. On the basis of parallel morphological studies, it is proposed that the effects of the septal grafts on the spatial learning impairments in the aged rats are critically dependent on the direct action of cholinergic neurons in the grafts via synapses formed onto neuronal elements in the host by their ingrowing axons.
Clinical Correlates of Human Immunodeficiency Virus–1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years (2019)

The prostratin analogue stimulation assay, with its lower blood volume requirement, could be a valuable method for evaluating inducible HIV-1 reservoirs in children. Standard commercial HIV serology may be a practical initial indirect measure of reservoir size in the peripheral blood of children with perinatally acquired HIV-1 infection.