gebhart/patrepeval huggingface dataset:
The Protective Effect of New Carnosine-Hyaluronic Acid Conjugate on the Inflammation and Cartilage Degradation in the Experimental Model of Osteoarthritis (2020)

Osteoarthritis (OA) is a disease that currently has no cure. There are numerous studies showing that carnosine and hyaluronic acid (HA) have a positive pharmacological action during joint inflammation. For this reason, the goal of this research was to discover the protective effect of a new carnosine conjugate with hyaluronic acid (FidHycarn) on the inflammatory response and on the cartilage degradation in an in vivo experimental model of OA. This model was induced by a single intra-articular (i.ar.) injection of 25 µL of normal saline with 1 mg of monosodium iodoacetate solution (MIA) in the knee joint of rats. MIA injection caused histological alterations and degradation of the cartilage, as well as behavioral changes. Oral treatment with FidHycarn ameliorated the macroscopic signs, improved thermal hyperalgesia and the weight distribution of the hind paw, and decreased histological and radiographic alterations. The oxidative damage was analyzed by evaluating the levels of nitrotyrosine and inducible nitric oxide synthase (iNOS) that were significantly reduced in FidHycarn rats. Moreover, the levels of pro-inflammatory cytokines and chemokines were also significantly reduced by FidHycarn. Therefore, for the first time, the effectiveness of oral administration of FidHycarn has been demonstrated in an osteoarthritis model. In conclusion, the new FidHycarn could represent an interesting therapeutic strategy to combat osteoarthritis.
Indolizidine alkaloid synthesis. Preparation of the pharaoh ant trail pheromone and gephyrotoxin 223 stereoisomers (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndolizidine alkaloid synthesis. Preparation of the pharaoh ant trail pheromone and gephyrotoxin 223 stereoisomersTimothy L. MacdonaldCite this: J. Org. Chem. 1980, 45, 1, 193–194Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/jo01289a049https://doi.org/10.1021/jo01289a049research-articleACS PublicationsRequest reuse permissionsArticle Views304Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cooperative activities of forearm muscles under loading applied to thumb or each finger (2018)

Human thumb and fingers are usually subjected to an external loading during daily activity. The information of how muscles in the forearm cooperate with each other in order to response to the external loading is still unknown. Such information may be helpful in understanding muscle function pathology and motor disorder. A novel method called electromyography computed tomography (EMG-CT) was developed to visualize muscle activity within a whole cross-section of the forearm by measuring surface EMG signals around the forearm. The current study aimed to extend the previous work by using the EMG-CT to investigate muscle cooperative activity under loading application to thumb or each finger. Loads of 0.98-9.8 N were applied to the thumb or each finger of four subjects in eight loading directions. The loading directions on thumb and index, middle, and little fingers were inner, outer, and upper directions. EMG signals around the subject’s forearm were recorded during the loading by using EMG band consisting of 40 pairs of bipolar electrodes. The results show different muscle cooperative activity pattern between loading conditions. During load was applied to thumb, muscle in lower region in pronation cross-section were highly active. When load was applied to a finger, muscles in lateral-lower region were highly active. In all subjects, total muscle activity in the whole cross-section and the maximum value of muscle activity increased in proportion to loading. This study demonstrates effectiveness of EMG-CT method by showing that the muscle cooperative activity of an individual is specific to force application conditions.
ChemInform Abstract: Asymmetric Catalysis with Substitutionally Labile Yet Stereochemically Stable Chiral‐at‐Metal Iridium(III) Complex. (2014)

Abstract Despite the substitutional lability of the title complex, which is required for coordination to the acylimidazole, the centrochirality at the metal atom is maintained during the reaction.
Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum (2023)

A sensor capable of quantifying both anti-SARS-CoV-2 spike receptor-binding domain (RBD) antibody levels and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in saliva and serum was developed. This was accomplished by exploiting the enzymatic reaction of maltose and orthophosphate (PO<sub>4</sub><sup>3-</sup>) in the presence of maltose phosphorylase to generate an equivalent amount of glucose that was detected using a commercial glucometer test strip and a potentiostat. Important for this approach is the ability to generate PO<sub>4</sub><sup>3-</sup> in an amount that is directly related to the concentration of the analytes. RBD-modified magnetic microparticles were used to capture anti-SARS-CoV-2 spike RBD antibodies, while particles modified with anti-SARS-CoV-2 nucleocapsid antibodies were used to capture SARS-CoV-2 nucleocapsid protein from inactivated virus samples. A magnet was used to isolate and purify the magnetic microparticles (with analyte attached), and alkaline phosphatase-conjugated secondary antibodies were bound to the analytes attached to the respective magnetic microparticles. Finally, through enzymatic reactions, specific amounts of PO<sub>4</sub><sup>3-</sup> (and subsequently glucose) were generated in proportion to the analyte concentration, which was then quantified using a commercial glucometer test strip. Utilizing glucose test strips makes the sensor relatively inexpensive, with a cost per test of ∼US $7 and ∼US $12 for quantifying anti-SARS-CoV-2 spike RBD antibody and SARS-CoV-2, respectively. Our sensor exhibited a limit of detection of 0.42 ng/mL for anti-SARS-CoV-2 spike RBD antibody, which is sensitive enough to quantify typical concentrations of antibodies in COVID-19-infected or vaccinated individuals (>1 μg/mL). The limit of detection for the SARS-CoV-2 virus is 300 pfu/mL (5.4 × 10<sup>6</sup> RNA copies/mL), which exceeds the performance recommended by the WHO (500 pfu/mL). In addition, the sensor exhibited good selectivity when challenged with competing analytes and could be used to quantify analytes in saliva and serum matrices with an accuracy of >94% compared to RT-qPCR.
High spontaneous emission coupling factor in photonic crystal nanolasers (2004)

We have demonstrated high spontaneous emission coupling factor ~ 0.1 from photonic crystal nanolasers with quantum dots. This high coupling resulted from narrow homogenous broadening of the quantum dots and the small number of resonances.
Intelligent system monitoring on large clusters (2006)

Modern data centers have a large number of components that must be monitored, including servers, switches/routers, and environmental control systems. This paper describes InteMon, a prototype monitoring and mining system for data centers. It uses the SNMP protocol to monitor a new data center at Carnegie Mellon. It stores the monitoring data in a MySQL database, allowing visualization of the time-series data using a JSP web-based frontend interface for system administrators. What sets InteMon apart from other cluster monitoring systems is its ability to automatically analyze correlations in the monitoring data in real time and alert administrators of potential anomalies. It uses efficient, state of the art stream mining methods to report broken correlations among input streams. It also uses these methods to intelligently compress historical data and avoid the need for administrators to configure threshold-based monitoring bands.
Long-Term Integrity of Waste Package Final Closure for HLW Geological Disposal, (VI) Consistency of the Structural Integrity Evaluation Model for the Weld Joint (2010)

Abstract Overpack, a container of high-level radioactive waste for Japan's geological disposal program, is required to prevent the sealed vitrified waste from coming into contact with groundwater for 1,000 years. This means that the same duration and function arerequired for the weld joint between the body and lid of the overpack. The authors have initiated studies on a methodology evaluating the long-term integrity of the lid closure, including welding tests and non-destructive examination tests, and proposed a structural integrity evaluation model for the lid closure as a basis for fracture mechanics assessment. The model makes two main assumptions consistent with six prerequisites. Thisarticle examines the consistency of the mechanical strength of the lid closure (one of the two assumptions) with its prerequisites, through a review of the test results of corrosion behavior and numerical calculations of neutron irradiation embrittlement for weld joints. Furthermore, a comparison of the critical crack lengths at different penetration depths was conducted, and an estimation of the maximum tolerable flaw size, which serves as a form of an acceptance criterion after adding a safety factor for the size of the weld flaw, was made. Based on these results, the consistency of the proposed evaluation model was discussed and identified. KEYWORDS: radioactive waste managementgeological disposalwaste packageoverpackfinalclosure weldstructural integritygeneral corrosionpreferential corrosionstress corrosion crackingneutron irradiation embrittlement
The Role of Palliative Care in Reducing Symptoms and Improving Quality of Life for Patients with Idiopathic Pulmonary Fibrosis: A Review (2020)

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with a median survival of 3-4 years from time of initial diagnosis, similar to the time course of many malignancies. A hallmark of IPF is its unpredictable disease course, ranging from long periods of clinical stability to acute exacerbations with rapid decompensation. As the disease progresses, patients with chronic cough and progressive exertional dyspnea become oxygen dependent. They may experience significant distress due to concurrent depression, anxiety, and fatigue, which often lead to increased symptom burden and decreased quality of life. Despite these complications, palliative care is an underutilized, and often underappreciated, resource before end-of-life care in this population. While there is growing recognition about early palliative care in IPF, current data suggest referral patterns vary widely based on institutional practices. In addition to focusing on symptom management, there is emphasis on supplemental oxygen use, pulmonary rehabilitation, quality of life, and end-of-life care. Importantly, increased use of support groups and national foundation forums have served as venues for further disease education, communication, and advanced care planning outside of the hospital settings. The purpose of this review article is to discuss the clinical features of IPF, the role of palliative care in chronic disease management, current data supporting benefits of palliative care in IPF, its role in symptom management, and practices to help patients and their caregivers achieve their best quality of life.
Extracellular Vesicles from Adipose-Derived Stem Cells Relieve Extremity Lymphedema in Mouse Models (2023)

This study may open up new possibilities for novel therapies for lymphedema.
Supplementary Data from Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells (2023)

Supplementary Data from Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells
RF response of PIN photodiode with avalanche multiplication using quantum dots (2013)

We fabricate a new PIN photodiode using InAs/InAlGaAs quantum dot absorption layer with an avalanche multiplication, low breakdown temperature coefficient, and high frequency response. Multiplication factors of M = 1 to M = 12 and the RF response over 10GHz are reported.
Radioligand Theranostics in the Management of Neuroendocrine Tumors (2020)

Harris, Alan G. MD, PhD∗; Vinik, Aaron I. MD†; O'Dorisio, Thomas M. MD‡; O'Dorisio, M. Sue MD, PhD§ Author Information
ChemInform Abstract: A Novel and Highly Efficient Desymmetrization of a meso‐Anhydride by a Chiral Grignard Reagent. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PromptonomyViT: Multi-Task Prompt Learning Improves Video Transformers using Synthetic Scene Data (2022)

Action recognition models have achieved impressive results by incorporating scene-level annotations, such as objects, their relations, 3D structure, and more. However, obtaining annotations of scene structure for videos requires a significant amount of effort to gather and annotate, making these methods expensive to train. In contrast, synthetic datasets generated by graphics engines provide powerful alternatives for generating scene-level annotations across multiple tasks. In this work, we propose an approach to leverage synthetic scene data for improving video understanding. We present a multi-task prompt learning approach for video transformers, where a shared video transformer backbone is enhanced by a small set of specialized parameters for each task. Specifically, we add a set of "task prompts", each corresponding to a different task, and let each prompt predict task-related annotations. This design allows the model to capture information shared among synthetic scene tasks as well as information shared between synthetic scene tasks and a real video downstream task throughout the entire network. We refer to this approach as "Promptonomy", since the prompts model task-related structure. We propose the PromptonomyViT model (PViT), a video transformer that incorporates various types of scene-level information from synthetic data using the "Promptonomy" approach. PViT shows strong performance improvements on multiple video understanding tasks and datasets. Project page: \url{https://ofir1080.github.io/PromptonomyViT}
Search for pair-produced dijet resonances in four-jet final states inppcollisions ats=7  TeV (2013)

A search for the pair production of a heavy, narrow resonance decaying into two jets has been performed using events collected in sqrt[s] = 7 TeV pp collisions with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 5.0 fb(-1). Events are selected with at least four jets and two dijet combinations with similar dijet mass. No resonances are found in the dijet mass spectrum. The upper limit at 95% confidence level on the product of the resonance pair production cross section, the branching fractions into dijets, and the acceptance varies from 0.22 to 0.005 pb, for resonance masses between 250 and 1200 GeV. Pair-produced colorons decaying into qq are excluded for coloron masses between 250 and 740 GeV.
(Invited) Strain Scaling and Modeling for FETs (2010)

Stress engineering overview is given including the reasons behind its ongoing evolution. Some aspects of the stress-induced defect formation are discussed. Guidelines for avoiding such defects are proposed based on stress evolution in and around transistors during the process flow. Stress-induced performance is addressed with the focus on conversion of stress-enhanced mobility into stress-enhanced on-state current. FinFET-specific stress engineering is analyzed as well as the stress vs capacitance trade-offs. Usage of simulation tools for optimization of various stress-related design trade-offs is demonstrated. It is concluded that it is a pursuit of beneficial stress patterns that improve transistor performance without creating defects and increasing variability that defines evolution of stress engineering techniques.
Low power techniques and design tradeoffs in adaptive FIR filtering for PRML read channels (2000)

In this paper, we describe area and power reduction techniques for a low-latency adaptive finite-impulse response filter for magnetic recording read channel applications. Various techniques are used to reduce area and power dissipation while speed remains as the main performance criterion for the target application. A parallel transposed direct form architecture operates on real-time input data samples and employs a fast, low-area multiplier based on selection of radix-8 pre-multiplied coefficients in conjunction with one-hot encoded bus leading to a very compact layout and reduced power dissipation. Area, speed and power comparisons with other low-power implementation options are also shown. The proposed filter has been fabricated using a 0.18 µm L-effective CMOS technology and operates at 550 MSamples/s.
Dielectric measurement of ferroelectric Sr0.61Ba0.39Nb2O6 single crystal fiber using cavity perturbation method (2005)

The nonlinear dielectric property of the ferroelectric Sr0.61Ba0.39Nb2O6 (SBN) crystal is essential to device application at various frequency ranges. The dielectric constant of the SBN single crystal fiber was investigated at x band microwave frequency using the resonant cavity perturbation method. It was found that compared with large and decreasing dielectric constant of SBN at low frequency, the dielectric property of the SBN crystal at x band frequency was smaller with similar value controlled by dipole orientation or atomic vibration.
Low-Complexity Symbol Timing Offset Estimation Schemes for OFDM Systems (2002)

In this paper, we propose three symbol synchronization schemes for Orthogonal Frequency Division Multiplex (OFDM) systems. The cyclic extension preceding OFDM symbols is of decisive importance for these schemes. The first scheme uses the phase-differential coding of the received OFDM signal. The second and the third schemes use the length of the received OFDM signal. All three schemes make symbol synchronization possible, even though there is a frequency offset in the system. Simulation results show that these schemes can be used to synchronize an OFDM system over AWGN and multi-path fading channels.
Photonic Structures: Hierarchical Nanoparticle Bragg Mirrors: Tandem and Gradient Architectures (Small 24/2011) (2011)

The cover picture shows a new kind of broadband optical reflector made by bottom-up self-assembly of nanoparticle metal-oxide multilayers fashioned as hierarchical nanoporous tandem and gradient Bragg mirrors. The optical properties of this genre of Bragg mirror can be passively tuned through variations of the composition of the nanoparticle metal-oxide layers and actively tuned through reversible adsorption–desorption of different molecular species in the nanopores, thereby providing myriad opportunities for the management of light in solar cells, photocatalysts, and photonic nose sensors in novel ways. For more information, please read the Full Paper “Hierarchical Nanoparticle Bragg Mirrors: Tandem and Gradient Architectures” by G. A. Ozin and co-workers, beginning on page 3465. Artwork credit: Wendong Wang.
Cell Adsorption and Selective Desorption for Separation of Microbial Cells by Using Chitosan-Immobilized Silica (2005)

Cell adsorption and selective desorption for separation of microbial cells were conducted by using chitosan-immobilized silica (CIS). When chitosan was immobilized onto silica surfaces with glutaraldehyde, bacterial cells adsorbed well and retained viability. Testing of the adsorption and desorption ability of CIS using various microbes such as Escherichia coli, Aeromonas hydrophila, Pseudomonas aeruginosa, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Lactobacillus casei, Streptococcus mutans, Streptococcus sobrinus, Streptococcus salivarius, Saccharomyces cerevisiae, Saccharomyces ludwigii, and Schizosaccharomyces pombe revealed that most microbes could be adsorbed and selectively desorbed under different conditions. In particular, recovery was improved when L-cysteine was added. A mixture of two bacterial strains adsorbed onto CIS could also be successfully separated by use of specific solutions for each strain. Most of the desorbed cells were alive. Thus, quantitative and selective fractionation of cells is readily achievable by employing chitosan, a known antibacterial material.
Developing an RNAi Therapeutic for Liver Disease Associated With Alpha-1-Antitrypsin Deficiency (2008)

AIM: Liver disease associated with Alpha-1-antitrypsin (AAT) deficiency is a common cause of both morbidity and mortality in patients. In >95% of these patients, expression of a mutant AAT allele called Z-AAT results in AAT protein misfolding and aggregation. Intracellular accumulation of Z-AAT protein aggregates ultimately compromises the hepatocyte and subsequently leads to liver disease. We propose that down regulating the mutant allele (Z-AAT) at the mRNA level will prevent the progression and development of liver disease. METHODS: A set of chemically modified siRNAs designed using bioinformatic algorithms was synthesized and screened by transfection in Hep3B cells for activity leading to selection of a highly potent siRNA for further studies. The siRNA was tested in transgenic mice expressing human Z-AAT. These mice develop liver disease and show protein accumulation similar to the human patients. RESULTS: We have developed a N-acetylgalactosamine (GalNAc) -conjugated siRNA (ALN-AAT). This allows for subcutaneous administration and is taken up by the hepatocytes via asialoglycoprotein receptor. Subcutaneous administration of the GalNAc-conjugated AAT siRNA, led to dose-dependent inhibition of serum human Z-AAT, with maximum inhibition of >95% observed at a dose of 3 mg/kg. A single dose of 1mg/kg maintained 40% levels of AAT for atleast 15 days. Repeat dosing of 0.5 mg/kg twice a week decreased AAT serum levels below 10% levels (90% suppression). Finally, 25-46-week-old Z-AAT transgenic mice administered GalNAc-AAT for 4 months exhibited decreased liver tumor incidence compared to untreated control animals. CONCLUSION: The robust suppression of AAT and subsequent phenotypic amelioration achieved by administration of GalNAc-AAT in a well-established mouse model of AAT-deficiency associated liver disease supports further development of this novel therapeutic strategy.