PD16-07 IMPACT OF SURGICAL MARGIN STATUS AFTER PARTIAL NEPHRECTOMY FOR RENAL CELL CARCINOMA (2018)

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III1 Apr 2018PD16-07 IMPACT OF SURGICAL MARGIN STATUS AFTER PARTIAL NEPHRECTOMY FOR RENAL CELL CARCINOMA Jong Soo Lee, Won Sik Jang, Jae Won Park, Dong Hoon Koh, Hyun Kyu Ahn, Kyung Taek Oh, Young Sig Kim, In Rae Cho, Joong Shik Lee, Won Tae Kim, Won Sik Ham, and Young Deuk Choi Jong Soo LeeJong Soo Lee More articles by this author , Won Sik JangWon Sik Jang More articles by this author , Jae Won ParkJae Won Park More articles by this author , Dong Hoon KohDong Hoon Koh More articles by this author , Hyun Kyu AhnHyun Kyu Ahn More articles by this author , Kyung Taek OhKyung Taek Oh More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , In Rae ChoIn Rae Cho More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Won Tae KimWon Tae Kim More articles by this author , Won Sik HamWon Sik Ham More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.819AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The clinical significance of surgical margin status after partial nephrectomy has lack of literature. Thus, we analyzed the association between positive surgical margin and risk of cancer recurrence in patients with clinically localized renal cell cancer who underwent partial nephrectomy. Moreover, we evaluated whether a minimal surgical margin less than 1 mm is really safe for cancer control after partial nephrectomy. METHODS We retrospectively reviewed medical records of 855 patients with clinical T1 renal mass who underwent partial nephrectomy at our institution between 2005 and 2014. After exclusion of patients who benign pathology were reported and those with incomplete pathological or follow-up data, 748 patients were included in the final analysis. We analyzed data using Kaplan-Meier method with log-rank tests and multivariate Cox regression models. RESULTS Of the 748 patients enrolled in this study, 704 (94.2%) had negative surgical margin and 44 (5.8%) had positive surgical margin. Recurrence-free survival for patients with positive surgical margin was significantly lower compared to those with negative surgical margin (p <0.001). When cases of negative surgical margin were divided by two groups (=1mm vs. <1 mm), there were no significant difference in recurrence-free survival (p = 0.604). Both univariate and multivariate Cox regression analyses showed positive surgical margin was a significant predictor of recurrence (hazard ratio 8.03, 95% confidence interval 2.74–23.56, p <0.001), while the safety margin of <1 mm was not (p = 0.680). CONCLUSIONS Our study shows that positive surgical margin resulting from partial nephrectomy increases the risk of recurrence in patients with renal cell cancer. Moreover, we demonstrated that even a safety margin less than 1 mm may be adequate to prevent recurrence. To confirm our findings, not only large-scale but also long-term studies are required. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e318-e319 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Jong Soo Lee More articles by this author Won Sik Jang More articles by this author Jae Won Park More articles by this author Dong Hoon Koh More articles by this author Hyun Kyu Ahn More articles by this author Kyung Taek Oh More articles by this author Young Sig Kim More articles by this author In Rae Cho More articles by this author Joong Shik Lee More articles by this author Won Tae Kim More articles by this author Won Sik Ham More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...