gebhart/patrepeval huggingface dataset:
Halothane fluorine-19 nuclear magnetic resonance in dipalmitoylphosphatidylcholine liposomes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalothane fluorine-19 nuclear magnetic resonance in dipalmitoylphosphatidylcholine liposomesLynda S. Koehler, Eric T. Fossel, and Karl A. KoehlerCite this: Biochemistry 1977, 16, 16, 3700–3707Publication Date (Print):August 9, 1977Publication History Published online1 May 2002Published inissue 9 August 1977https://pubs.acs.org/doi/10.1021/bi00635a030https://doi.org/10.1021/bi00635a030research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gate-tunable optical extinction of graphene nanoribbon nanoclusters (2021)

We investigate the optical response of graphene nanoribbons (GNRs) using the broadband nonlinear generation and detection capabilities of nanoscale junctions created at the LaAlO3/SrTiO3 interface. GNR nanoclusters measured to be as small as 1–2 GNRs in size are deposited on the LaAlO3 surface with an atomic force microscope tip. Time-resolved nonlinear optical probes of GNR nanoclusters reveal a strong, gate-tunable second and third harmonic response, as well as strong extinction of visible to near-infrared light at distinct wavelengths, similar to previous reports with graphene.
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement (2022)

Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. With the support of the European Society of Endocrinology, the Growth Hormone Research Society convened a Workshop, where 55 international key opinion leaders representing 10 professional societies were invited to participate. This consensus statement utilized: (1) a critical review paper produced before the Workshop, (2) five plenary talks, (3) evidence-based comments from four breakout groups, and (4) discussions during report-back sessions. Current evidence reviewed from the proceedings from the Workshop does not support an association between GH replacement and primary tumour or cancer recurrence. The effect of GH replacement on secondary neoplasia risk is minor compared to host- and tumour treatment-related factors. There is no evidence for an association between GH replacement and increased mortality from cancer amongst GH-deficient childhood cancer survivors. Patients with pituitary tumour or craniopharyngioma remnants receiving GH replacement do not need to be treated or monitored differently than those not receiving GH. GH replacement might be considered in GH-deficient adult cancer survivors in remission after careful individual risk/benefit analysis. In children with cancer predisposition syndromes, GH treatment is generally contraindicated but may be considered cautiously in select patients.
X-Ray and near-infrared imaging: similarities, differences and combinations (2010)

The integration of x-ray imaging with optical imaging is becoming routine at the pre-clinical level, as both projection and tomography systems are now commercially integrated as packaged systems. Yet, the differences between their capabilities are wide, and there is still perhaps a lack of appreciation about how difference pre-clinical x-ray systems are from clinical x-ray systems. In this survey, the key advantages of each approach, x-ray and optical, are described, and the potential synergies and deficiencies are discussed. In simple terms, the major benefit of optical imaging is in the spectroscopic capabilities, which allow the potential for imaging fluorescent agents in vivo, and the future potential for imaging multiple species at a time with spectral discrimination or spectral fitting of the data. In comparison, multienergy x-ray systems are being realized in clinical use, or automated discrimination of soft versus hard tissues, and the combination of optical imaging with this type of dual-energy x-ray imaging will significantly enhance the capabilities of the hybrid systems. Unfortunately, the power of dual energy imaging is not as possible at the pre-clinical stage, because of the limitations of contrast-resolution and x-ray dose. This is discussed and future human systems outlined.
Optimizing Multiple Machine Learning Jobs on MapReduce (2011)

Recently, MapReduce has been used to parallelize machine learning algorithms. To obtain the best performance for these algorithms, tuning the parameters of the algorithms is required. However, this is time consuming because it requires executing a MapReduce program multiple times using various parameters. Such multiple executions can be assigned to a cluster in various ways, and the execution time varies depending on the assignments. To achieve the shortest execution time, we propose a method for optimizing the assignment of MapReduce jobs to a cluster assuming machine learning targeted runtime. We developed an execution cost model to predict the total execution time of jobs and obtained the optimal assignment by minimizing the cost model. To evaluate the proposed method, we implemented an experimental MapReduce runtime based on Message Passing Interface and executed logistic regression in four cases. The results showed that the proposed method can correctly predict the optimal job assignment. We also confirmed that the optimal assignment reduced execution time by a maximum 77% compared to the worst assignment.
Ergot alkaloid mycotoxins: physiological effects, metabolism and distribution of the residual toxin in mice (2020)

The complex ergot alkaloids, ergovaline and ergotamine, cause dysregulation of physiological functions, characterised by vasoconstriction as well as thermoregulatory and cardiovascular effects in grazing livestock. To assess the effect of the mycotoxins, blood pressure and heart rate of male mice were measured, and metabolite profiling undertaken to determine relative abundances of both ergotamine and its metabolic products in body and brain tissue. Ergotamine showed similar cardiovascular effects to ergovaline, causing elevations in blood pressure and reduced heart rate. Bradycardia was preserved at low-levels of ergovaline despite no changes in blood pressure. Ergotamine was identified in kidney, liver and brainstem but not in other regions of the brain, which indicates region-specific effects of the toxin. The structural configuration of two biotransformation products of ergotamine were determined and identified in the liver and kidney, but not the brain. Thus, the dysregulation in respiratory, thermoregulatory, cardiac and vasomotor function, evoked by ergot alkaloids in animals observed in various studies, could be partially explained by dysfunction in the autonomic nervous system, located in the brainstem.
Bulk breakdown of high field silicon-dielectric systems (1995)

Preliminary results on bulk breakdown in high field silicon-dielectric systems are reported. In most cases the total breakdown of the above systems takes place by surface flashover. Bulk breakdown in high field semiconductor-dielectric systems is supposed to be produced only when one or more large filaments are developed in the bulk of the material due to a particular defect configuration. The characteristics of the bulk breakdown of the system are totally different from surface flashover. These differences are explained by the different physical nature of the two kinds of the breakdown of the system, one located in the material bulk and other at the semiconductor-dielectric interface.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Benefits of modulation diversity in turbo-coded OFDM systems (2005)

We show that the use of modulation diversity provides gains to punctured, turbo-coded OFDM systems. For an OFDM transmission scenario, based on the downlink of the 3GPP standard for mobile communications, we show that the order-2 modulation diversity, observed for the raw bit-error rate, transfers to the block-error rate in a number of investigated channel environments. We demonstrate gains of up to 2.5 dB, depending on the puncturing rate of the scheme and the particular channel characteristics. Alternatively, for schemes with higher puncturing rates, 2 or 3 turbo decoder iterations suffice to achieve the same performance as achieved by 8 decoder iterations in a regular transmission.
Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections (2012)

Pathogenic bacteria have evolved multiple mechanisms aimed to evade host defenses. This review summarizes selected examples of how bacteria utilize proteolytic enzymes to efficiently establish and spread infection systemically. First, the role of proteases in intracellular survival and persistence – the primary means used by bacteria to endure phagocytosis and/or avoid the vigilance of the immune system – is discussed. Second, it is demonstrated how some bacteria escape entanglement in fibrin(ogen) meshes, by inducing their proteolytic dissolution while other species modify the proteolytic cascade of mesh formation to divert this important innate immune defense for their own benefit. Third, bacterial proteolytic toxins are introduced, which allow microorganisms to exert and take advantage of systemic effects already during primary, localized infection. Finally, it is discussed how viruses utilize bacterial proteases by taking advantage of concurrent infection, and how pathogens may even mutually benefit from the joint presence of other pathogens. The reviewed adaptations are often essential for pathogen survival in the hostile environment of a host organism. As such, the potential benefits of pharmacological interference in relevant pathways for the struggle against bacterial pathogens are also discussed. Keywords: Protease, proteinase, bacteria, intracellular survival, coagulation, fibrinolysis, toxins, viral infection, pathogenesis.
SIZER: A Dataset and Model for Parsing 3D Clothing and Learning Size\n Sensitive 3D Clothing (2020)

While models of 3D clothing learned from real data exist, no method can\npredict clothing deformation as a function of garment size. In this paper, we\nintroduce SizerNet to predict 3D clothing conditioned on human body shape and\ngarment size parameters, and ParserNet to infer garment meshes and shape under\nclothing with personal details in a single pass from an input mesh. SizerNet\nallows to estimate and visualize the dressing effect of a garment in various\nsizes, and ParserNet allows to edit clothing of an input mesh directly,\nremoving the need for scan segmentation, which is a challenging problem in\nitself. To learn these models, we introduce the SIZER dataset of clothing size\nvariation which includes $100$ different subjects wearing casual clothing items\nin various sizes, totaling to approximately 2000 scans. This dataset includes\nthe scans, registrations to the SMPL model, scans segmented in clothing parts,\ngarment category and size labels. Our experiments show better parsing accuracy\nand size prediction than baseline methods trained on SIZER. The code, model and\ndataset will be released for research purposes.\n
Impact of Race and Insurance Status on Surgical Approach for Cervical Spondylotic Myelopathy in the United States (2016)

3.
Dynamic Nuclear Polarization of 17O: Direct Polarization (2013)

Dynamic nuclear polarization of (17)O was studied using four different polarizing agents: the biradical TOTAPOL and the monoradicals trityl and SA-BDPA, as well as a mixture of the latter two. Field profiles, DNP mechanisms, and enhancements were measured to better understand and optimize directly polarizing this low-gamma quadrupolar nucleus using both mono- and biradical polarizing agents. Enhancements were recorded at <88 K and were >100 using the trityl (OX063) radical and <10 with the other polarizing agents. The >10,000-fold savings in acquisition time enabled a series of biologically relevant small molecules to be studied with small sample sizes and the measurement of various quadrupolar parameters. The results are discussed with comparison to room temperature studies and GIPAW quantum chemical calculations. These experimental results illustrate the strength of high field DNP and the importance of radical selection for studying low-gamma nuclei.
An ecological association of number of civil servants and physicians with prefectural-level rapid COVID-19 vaccination of older people in Japan (2023)

We found that COVID-19 vaccine uptake among older people was more rapid in prefectures with more civil servants and physicians per population, with the number of physicians having a stronger association. This study may point the way to future areas of research on vaccine policies that include other age groups and infectious diseases.
Emerging Methods for Biological Control of Barley Diseases Including the Role of Endophytes (2019)

Barley is an important crop worldwide with production largely used for animal feed and alcoholic beverages.Diseases are a major limiting factor to its production.Th ese have, up until recently, been controlled by agrochemicals.However, legislation on the use of agrochemicals, especially within the European Union, is being tightened and there is growing interest in integrated pest management .Th is means that there is an increasing focus on controlling diseases using biological control .Living microorganisms that are applied as biological control agents (BCAs) to either soil, seed or leaves can have diffi culty in persisting.Th erefore, the focus of this review is on endophytes, which are microorganisms that live inside the plant without causing symptoms of disease and have the potential of staying protected as well as being benefi cial to the plant and eff ective against multiple diseases.In this review, we discuss the diff erent approaches for fi nding and testing benefi cial endophytes and for determining the endophyte host range.Furthermore, we undertook a literature search to summarise previous studies that have investigated the use of endophytes as well as BCAs against barley diseases.
A versatile 250/300-V IC process for analog and switching applications (1986)

A true analog high-voltage IC process and related devices are described. The process is based on bipolar low-voltage devices to which have been added 300-V lateral n-MOS and p-MOS transistors with source-follower capability. The present process version includes 250-V vertical DMOS transistors for compact switching of moderate power, whereas 5/20-V CMOS is available for control. Application examples are an 8-MHz video output amplifier and a 20-W full-bridge power switch.
Profiling glycosphingolipid structural detail: Periodate oxidation, electrospray, collision‐induced dissociation and tandem mass spectrometry (1994)

Abstract Electrospray ionization mass spectrometry applied to methylated glycosphingolipid samples provides a sensitive molecular mass profile with no detectable fragmentation and little matrix background. In a bovine brain preparation, the components G M1a , G D1a/b and G T1a/b were characterized in detail and several minor entities, G T1 , G M3 , G A1 , G M2 , were mass profiled. Two additional materials, unrelated to the o‐, a‐, b‐ or c‐series, were characterized as hexosamine additions to G M1 and G D1a . Structural details of the major components within these samples were obtained by utilizing low‐energy collision tandem mass spectrometry and periodate oxidation, which could serve as a basis for more complex and higher molecular mass preparations. Fragment structures in the collision spectra were assigned with the assistance of C 1 H 3 and C 2 H 3 derivatization and by exploiting the natural carbohydrate and ceramide heterogeneity of the samples. Major fragments originate from C 1 O glycosidic rupture with few ring‐opening ions. Glycosidic fragments defined details that allow the determination of structural isomers, while specific fragments of the ceramide moiety differentiate sphingosine from N ‐acyl heterogeneity. When contrasted with high‐energy (8 keV) tandem mass spectrometry, low‐energy collision‐induced dissociation of multiply charged molecular ions provided more abundant structurally diagnostic fragments.
Extra-corporeal life support following cardiac surgery in children: analysis of risk factors and survival in a single institution (2009)

ECLS plays a valuable role in children with low cardiac output state following cardiac surgery. More than one third of those patients, including young neonates, older children, patients with single ventricle, or those requiring rescue ECMO can be salvaged. Although prognosis worsens with prolonged ECLS duration, survival can be noted up to 16 days of support. Heart transplantation is often an important ECLS exit strategy and should be considered early in selected children. Patients' survival could improve if renal and neurological complications are avoided.
The Effect of Nonsteroidal Anti-Inflammatory Agents on Spinal Fusion (2005)

A large body of information suggests NSAIDS have a negative impact on the healing of bone. Although each clinical healing scenario presents a slightly different level of challenge, the healing of a posterolateral spinal fusion is one of the most difficult challenges in bony healing. Clinically, this results in a relatively high rate of nonunions using traditional fusion techniques. Spinal fusion models have confirmed NSAIDS have a definite inhibitory effect on healing of the fusion. Although data are limited, it appears this effect is most severe when NSAIDS are administered in the early postoperative period. Moreover, the effect may be worse with certain types initial inflammatory, subsequent reparative, and final remodeling phases. Because of the anti-inflammatory activity of NSAIDS, one might assume their effects would be worse when administered in the inflammatory phase. Indeed, the study by Riew et al suggests the inhibitory effects are more significant when NSAIDS are administered earlier following fusion. Other studies conducted with non-spinal models also suggest early administration of NSAIDS results in greater inhibition of bone formation (Goodman et al). Unfortunately, the length of the inflammatory phase in humans is not well known. This leaves the clinician unsure about the safe time to allow resumption of NSAID usage clinically. It appears likely NSAID use following a spinal fusion procedure will increase the rate of pseudarthrosis. The literature suggests that avoidance of NSAIDS in the postoperative period may avoid nonunion. Additionally, we propose that chronic NSAID usage should be addressed in a similar manner to cigarette smoking. While neither are absolute contraindications to elective spinal fusion, patients should be counseled to discontinue the use of NSAIDS in the peri- and postoperative period to maximize their chance for a successful fusion.
Light sheet fluorescence microscope for microfluidic chip (2020)

We present a light sheet fluorescence microscope dedicated to image “Organ-on-chip”-like biostructures in microfluidic chip. Based on a simple design, the setup is built around the chip and its environment to allow 3D imaging inside the chip in a microfluidic laboratory. The experimental setup, its optical characterization and first volumetric images are reported.
CT arthrography of the human knee to measure cartilage quality with low radiation dose (2012)

CTa acquired using low radiation exposure, comparable to a regular knee CT, is able to measure overall cartilage quality. Spatial sGAG distribution can also be determined using CTa, however for this purpose a higher radiation dose is necessary. Nevertheless, radiation dose reduction makes CTa suitable for quantitative analysis of cartilage in clinical research.
Interaction and self assembly of globular proteins : mechanism and properties of formed supramolecular structures (2011)

Interaction and self assembly of globular proteins : mechanism and properties of formed supramolecular structures
Supplementary Figure SF2. from Novel Paired Normal Prostate and Prostate Cancer Model Cell Systems Derived from African American Patients (2023)

&lt;p&gt;Figure S2. Western analysis of AR and p53. Cells were examined for expression levels of AR and p53 in a set of cell cultures. LNCaP (AR-dependent and p53+) and PC3 (AR-independent and p53 null) cells were used as controls for AR and p53 expression. Actin was used as the loading control.&lt;/p&gt;
Robust online visual tracking via a temporal ensemble framework (2016)

In this paper, we propose a robust visual tracking method based on a temporal ensemble framework. Different from conventional ensemble-based trackers, which combine weak classifiers into a strong one using AdBoost in spatial fusion manners, our method adopts a powerful and efficient tracker integrated with its snapshots in different temporal windows of online tracking process to construct a temporal ensemble framework. Specifically, an adaptive correlation filter classifier is employed as the base tracker. During online tracking, the ensemble model determines the output through fusion of the base tracker's snapshots based on their response scores. By the temporal ensemble, accumulated errors caused by undesirable update can be corrected which greatly improves the robustness of the tracking system. Encouraging experimental results on challenging benchmark video sequences demonstrate that the proposed tracking method outperforms several state-of-the-art trackers in terms of both precision and robustness.
A Silicon Photonic Data Link with a Monolithic Erbium-Doped Laser (2020)

To meet the increasing demand for data communication bandwidth and overcome the limits of electrical interconnects, silicon photonic technology has been extensively studied, with various photonics devices and optical links being demonstrated. All of the optical data links previously demonstrated have used either heterogeneously integrated lasers or external laser sources. This work presents the first silicon photonic data link using a monolithic rare-earth-ion-doped laser, a silicon microdisk modulator, and a germanium photodetector integrated on a single chip. The fabrication is CMOS compatible, demonstrating data transmission as a proof-of-concept at kHz speed level, and potential data rate of more than 1 Gbps. This work provides a solution for the monolithic integration of laser sources on the silicon photonic platform, which is fully compatible with the CMOS fabrication line, and has potential applications such as free-space communication and integrated LIDAR.