gebhart/patrepeval huggingface dataset:
Characterization of Aluminium and Titanium Oxides Deposited on 4H-SiC by Atomic Layer Deposition Technique (2005)

Aluminium oxide and titanium oxide films were deposited using the Atomic Layer Deposition method on n-type 4H SiC and p-type Si {001} substrates, with doping 6×1015cm-3 and 2×1016cm-3, respectively, and on 1.2 kV PiN 4H SiC diodes for passivation studies. The Al2O3 and SiC interface was characterised for the existence of an effective negative charge with a density of 1×1012-2×1012 cm-2. The dielectric constant of Al2O3 as determined from capacitance-voltage data was about 8.3. The maximum electric field supported by the Al2O3 film was up to 7.5 MV/cm and 8.4 MV/cm on SiC and Si, respectively.
A 4‘-C-Ethynyl-2‘,3‘-Dideoxynucleoside Analogue Highlights the Role of the 3‘-OH in Anti-HIV Active 4‘-C-Ethynyl-2‘-deoxy Nucleosides (2004)

4'-C-ethynyl-2'-deoxynucleosides belong to a novel class of nucleoside analogues endowed with potent activity against a wide spectrum of HIV viruses, including a variety of resistant clones. Although favorable selectivity indices were reported for several of these analogues, some concern still exists regarding the 3'-OH group and its role in cellular toxicity. To address this problem, we removed the 3'-OH group from 4'-C-ethynyl-2'-deoxycytidine (1a). This compound was chosen because of its combined high potency and low selectivity index. The removal of the 3'-OH was not straightforward; it required a different synthetic approach from the one used to synthesize the parent compound. Starting with glycidyl-4-methoxyphenyl ether, the target 4'-C-ethynyl-2',3'-dideoxycytidine analogue (rac-1h) was obtained after 13 steps. In a cellular assay, rac-1h was completely inactive (0.001-10 microM) against HIV(LAI), demonstrating the critical importance of the 3'-OH for antiviral activity. To determine whether the role of the 3'-OH was essential for the phosphorylation of the compound by cellular kinases or for inhibition of DNA polymerization, we synthesized and tested the 5'-triphosphate (rac-1h-TP) for its ability to inhibit HIV reverse transcriptase (RT). rac-1h-TP was slightly more potent than AZT-5'-triphosphate against wild-type HIV RT, suggesting that the role of the 3'-OH is crucial only for the activation of the drug by cellular kinases. The lipase-catalyzed resolution of rac-1h into ent-1h (beta-D-dideoxyribo) and ent-14 (beta-L-dideoxyribo) and the synthesis of the corresponding 5'-triphosphates established the stereochemical assignment based on HIV RT's preference for the beta-D-enantiomer, which was confirmed by assaying against the M184V variant, an RT mutant with a marked preference for incorporating nucleosides in the D-configuration.
High-Efficiency White Polymer Light-Emitting Diodes Based on Blended RGB Polymers (2006)

We have fabricated white polymer light-emitting devices (WPLEDs) from RGB polymer blending systems using ITO/PEDOT:PSS/blended polymers/LiF/Al structure. The highest current efficiency reached 5.34 cd/A and the maximum brightness value of 27,000 cd/m2 at 11.4 V was obtained. As the green dopant concentration increased, the spectrum deviated from the white because of more energy transfer from host to guest. As a result, the 450 nm blue peak was reduced by increasing green dopant ratio. On the other hand, 600 nm red shoulder peaks were slightly increased at the same conditions. Therefore, red-orange and green electroluminescence emissions are promoted by excitation energy and charge transfer from the blue host polymer to the dopants.
Macrophage-Targeted Photodynamic Therapy: Scavenger Receptor Expression and Activation State (2005)

Macrophage-targeted photodynamic therapy (PDT) may have applications in the selective killing of cells involved in atherosclerosis, inflammation and tumor. We have previously shown that a conjugate between the photosensitizer chlorin(e6) (ce6) and maleylated bovine serum albumin (BSA-mal) gives highly selective targeting to macrophages. In this report we examine the effect of macrophage activation and scavenger receptor class A (SRA) expression on this targeting in two murine macrophage tumor cell lines (RAW264.7 and P388D1) and a control murine mammary sarcoma cell line (EMT-6). Cells were pretreated with interferon gamma (IFNgamma) and/or lipopolysaccharide (LPS) followed byBSA-ce6-mal addition, and SRA expression, tumor necrosis factor alpha (TNFalpha) release, conjugate uptake and PDT killing were measured. Both macrophage cell lines expressed SRA and took up conjugate specifically in an SRA-dependent manner, but differences were observed in their response to activation. RAW264.7 expressed increasingly more SRA and took up increasingly more BSA-ce6-mal in response to IFNgamma, LPS, and IFNgamma+LPS, respectively. The PDT killing did not follow the same pattern as the uptake of the photosensitizer. The increase in uptake in the IFNgamma treated cells did not lead to an increase in PDT killing, while stimulation with LPS or IFNgamma + LPS resulted in a significant protection against PDT, despite a significant increase in photosensitizer uptake. P388D1 was responsive to neither IFNgamma, nor to LPS, or to IFNgamma +LPS with respect to SRA expression, conjugate uptake, and PDT killing. These data may have implications for the use of PDT to target physiologically undesirable macrophage subtypes implicated in disease, and on how manipulation of the activation status of the macrophage will influence the PDT effect.
Robust spectrum quantization for LP parameter enhancement (2004)

In this paper, we investigate the denoising properties of ro-bust vector quantization of the speech spectrum parameters in combination with a Kalman lter. The underlying assump-tion is that the high-energy speech regions can be used to re-construct the low-energy regions destroyed by noise. This can be achieved through vector quantization with a properly weighted distortion measure. The performance of the pro-posed system, Kalman ltering with prior vector quantiza-tion, is compared with existing schemes for parameter esti-mation used in Kalman ltering. The results indicate signif-icant improvement over the reference systems in both objec-tive and subjective tests. 1.
ChemInform Abstract: Synthesis of β‐Mannopyranosides by Intramolecular Aglycon Delivery. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Crosstalk and microlens study in a color CMOS image sensor (2003)

The paper describes results of crosstalk investigations and microlens (/spl mu/-lens) scan experiments in a color CMOS image sensor with active pixel structure . The investigation of optical and electrical crosstalk was made on 7.8- and 5.6-/spl mu/m pixels by using samples with continuous shift of color filter (CF ) and /spl mu/-lens across the array. As a result of this investigation, the distribution of sensitivity inside a pixel has been determined. By using minimum crosstalk criteria, the optimum parameters of the /spl mu/-lens manufacturing process and optimum position of the /spl mu/-lens was determined. The paper presents color maps of pixel sensitivity and crosstalk criteria as well as snapshots illustrating sensitivity distribution and collection area. The paper presents spectral characteristics measured at different relative apertures (f-number) as well. The quantitative analysis of spectral responses allowed us to determine the contribution of each component to the overall crosstalk.
Expression of cellular antigens of Listeria monocytogenes that react with monoclonal antibodies C11E9 and EM-7G1 under acid-, salt- or temperature-induced stress environments (2003)

Bacteria in food are routinely subjected to various stresses, induced by cold, heat, salt or acid during processing and storage. Whether stresses would modify the expression of cellular antigens of L. monocytogenes is of a great concern for immunodetections in food products.
Single‐Pass Continuous Flow Peritoneal Dialysis Using Two Catheters (2001)

With a renewed interest in continuous flow peritoneal dialysis (CFPD), our standard practice of implanting a second catheter in those patients facing access failure provided us the opportunity to perform acute studies on CFPD in these patients, since it temporarily provided us with two catheters. Four patients were studied, with a total of five studies performed. A standard protocol was followed utilizing 1.5% dextrose solution, a 2 L fill, an inflow rate of 200 ml/min with a proportionate outflow for a 4-hour session. A full drain was performed at the end of the study. Our results provided us with a mean effective peritoneal clearance for urea (KpeU) and creatinine (KpeCr) of 40 ml/min and 28 ml/min, respectively, and a mean ultrafiltration rate (Qf) of 13.4 ml/min. Our average mass transfer coefficient (MTC) for urea was 40 ml/min, consistent with kinetic modeling and historical data. The Kpe, MTC, and Qf achieved are significantly higher than other investigators, which could possibly be explained by those obtained by two separate catheters resulting in adequate mixing of the dialysate. These clinical results provide a solid foundation for the future development of this PD modality.
Ideal velocity focusing in a reflectron time-of-flight mass spectrometer (1999)

A single-stage ion mirror in a time-of-flight (TOF) mass spectrometer (MS) can perform first order velocity focusing of ions initially located at a start focal plane while second order velocity focusing can be achieved using a double-stage reflectron. The situation is quite different when an ion source extraction field is taken into account. In this case which is common in any practical matrix-assisted laser desorption/ionization (MALDI) TOF-MS a single-stage reflectron, for example, cannot perform velocity focusing at all. In this paper an exact, analytic solution for an electric field inside a one-dimensional reflectron has been found to achieve universal temporal focusing of ions having an initial velocity distribution. The general solution is valid for arbitrary electric field distributions in the upstream (from the ion source to the reflectron) and downstream (from the reflectron to an ion detector) regions and in a decelerating part of the reflectron of a reflectron TOF mass spectrometer. The results obtained are especially useful for designing MALDI reflectron TOF mass spectrometers in which the initial velocity distribution of MALDI ions is the major limiting factor for achieving high mass resolution. Using analytical expressions obtained for an arbitrary case, convenient working formulas are derived for the case of a reflectron TOF-MS with a dual-stage extraction ion source. The special case of a MALDI reflectron TOF-MS with an ion source having a low acceleration voltage (or large extraction region) is considered. The formulas derived correct the effect of the acceleration regions in a MALDI ion source and after the reflectron before detecting ions.
Memories of a Senior Scientist Functions of mitochondria: from intracellular power stations to mediators of a senescence program (2009)

In 1950 s I started in science by showing that non-phosphorylating respiration is critical for survival of an animal at low temperature. Later, in the 1960 s and 1970 s, I took part in verification of Mitchells chemiosmotic hypothesis postulating that (i) mitochon- dria transform energy of respiration to electricity and (ii) uncoupling of respiration represents discharge of this electricity by H + cycling. Fifteen years ago I turned to a specific kind of mitochondrial respiration which produces O2 -. , and I came to the conclusion that it plays an ominous role, killing mitochondria, cells, or even organisms. My present task is a megaproject with an ambitious goal of minimizing the damaging effect of O2 - . and stopping senescence.
VCSEL-based miniature laser-Doppler interferometer (2008)

There are many applications for non-contact measurement of the displacement and velocity of moving objects, especially when achieved at low cost. An optical displacement sensor has been developed that can be compared to expensive laser-interferometry sensors, however at a cost compatible with requirements for consumer products. This miniature Laser-Doppler Interferometer works on all light scattering surfaces. The first large-scale application is in PC-mice. The measurement principle employs so-called "Laser Self Mixing", which occurs when laser light scattered on a surface, within the coherence length, is coupled back into the laser cavity. When the object is moving, the back-scattered light is continuously shifting in phase relative to the laser light at the laser mirror. This results in a periodic perturbation of the feedback into the laser cavity, which causes modulations of the light intensity in the cavity. The frequency of these modulations is proportional the speed of the object. A VCSEL, optimized for this application, is used as light source, a photo-diode in the sensor measures the intensity fluctuations and, finally, an integrated circuit transfers the photo-diode signal into velocity or displacement information. To determine the direction of the movement, a triangle modulation of the laser-current is used, which modulates the laser-temperature and hence the laser frequency. Next to the applications in PC-mice a much wider range of applications as input device in consumer products can be envisaged. For instance menu navigation by finger movement over a sensor in remote controls, mobile phones and lap tops. Furthermore a wide field of applications is envisaged in the manufacturing of industrial equipment, which requires non-contact measurement of the movement of materials. The small form factor of less than 0.2 cubic centimeters allows applications previously considered impossible.
On-chip broadband spectral filtering using planar double high-contrast grating reflectors (2015)

We propose a broadband free-space on-chip spectrometer based on an array of integrated narrowband filters consisting of Fabry-Perot resonators formed by two high-contrast grating (HCG) based reflectors separated by a low-index thin layer with a fixed cavity thickness. Using numerical simulations, broadband tunability of resonance wavelengths was achieved only by changing the in-plane grating parameters such as period or duty cycle of HCGs while the substrate geometry was kept fixed. Experimentally, the HCG reflectors were fabricated on silicon on insulator (SOI) substrates and high reflectivity was measured, fabrication process for the proposed double HCG-based narrowband filter array was developed. The filtering function that can be spanned over a wide range of wavelengths was measured.
Impaired Angiogenesis in Glutathione Peroxidase-1–Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction (2005)

Several vascular disease are characterized by elevated levels of reactive oxygen species (ROS). Vascular endothelium is protected from oxidant stress by expressing enzymes such as glutathione peroxidase type 1 (GPx-1). In this study, we investigated the effect of vascular oxidant stress on ischemia-induced neovascularization in a murine model of homozygous deficiency of GPx-1. GPx-1-deficient mice showed impaired revascularization following hindlimb ischemic surgery based on laser Doppler measurements of blood flow and capillary density in adductor muscle. GPx-1-deficient mice also showed an impaired ability to increase endothelial progenitor cell (EPC) levels in response to ischemic injury or subcutaneous administration of vascular endothelial growth factor protein. EPCs isolated from GPx-1-deficient mice showed a reduced ability to neutralize oxidative stress in vitro, which was associated with impaired migration toward vascular endothelial growth factor and increased sensitivity to ROS-induced apoptosis. EPCs isolated from GPx-1-deficient mice were impaired in their ability to promote angiogenesis in wild-type mice, whereas wild-type EPCs were effective in stimulating angiogenesis in GPx-1-deficient mice. These data suggest that EPC dysfunction is a mechanism by which elevated levels of ROS can contribute to vascular disease.
Ultimate Resolution for Current Localization by Means of Magnetic Techniques (2009)

Abstract Defect localization is a very important step in the process of failure analysis for Integrated Circuits. A very important technique, allowing the localization of the defects with a certain degree of precision, is Magnetic Current Imaging. However, this technique has strict limitations related to the working distance and the maximum current magnitude detectable. We overcame these limitations by using a simulation approach, allowing us to sensibly increase the technique resolution and to map currents which are much weaker. This is done by comparing the measurement of the Magnetic Induction Field to a set of simulations of defect assumptions.
Catching Falling Dominoes: Cloud Management-Level Provenance Analysis with Application to OpenStack (2020)

The dynamicity and complexity of clouds highlight the importance of automated root cause analysis solutions for explaining what might have caused a security incident. Most existing works focus on either locating malfunctioning clouds components, e.g., switches, or tracing changes at lower abstraction levels, e.g., system calls. On the other hand, a management-level solution can provide a big picture about the root cause in a more scalable manner. In this paper, we propose DOMINOCATCHER, a novel provenance-based solution for explaining the root cause of security incidents in terms of management operations in clouds. Specifically, we first define our provenance model to capture the interdependencies between cloud management operations, virtual resources and inputs. Based on this model, we design a framework to intercept cloud management operations and to extract and prune provenance metadata. We implement DOMINOCATCHER on OpenStack platform as an attached middleware and validate its effectiveness using security incidents based on real-world attacks. We also evaluate the performance through experiments on our testbed, and the results demonstrate that DOMINOCATCHER incurs insignificant overhead and is scalable for clouds.
How VLIW almost disappeared - and then proliferated (2009)

Very long instruction word (VLIW) refers to a computer architecture and algorithms that take advantage of large amounts of instruction level parallelism (ILP). Joseph A. (Josh) Fisher, a former Yale professor and a Hewlett-Packard Senior Fellow, introduced VLIW architecture in the early 1980s. The insights underlying Fisher's invention of VLIW came to him when he was a graduate student at New York University's Courant Institute in the late 1970s. He was microcoding a clone of the Control Data Corporation (CDC) 6600 computer. To maximize the performance of the clone, called PUMA, he used a standard trick of writing microcode with many concurrent operations. In doing so, he realized he could get even more concurrency and performance by moving operations speculatively above branches. His study of this motion, and how it violated the laws of computer architecture of the day, led to his invention of the trace scheduling compiler algorithm. He wrote his Ph.D. thesis about trace scheduling. He later became a professor at Yale University, where he started the Extremely Long Instruction (ELI) project, which developed the architecture for the trace scheduling compiler.
A Simple and Efficient Multi-task Network for 3D Object Detection and Road Understanding (2021)

Detecting dynamic objects and predicting static road information such as drivable areas and ground heights are crucial for safe autonomous driving. Previous works studied each perception task separately, and lacked a collective quantitative analysis. In this work, we show that it is possible to perform all perception tasks via a simple and efficient multi-task network. Our proposed network, LidarMTL, takes raw LiDAR point cloud as inputs, and predicts six perception outputs for 3D object detection and road understanding. The network is based on an encoder-decoder architecture with 3D sparse convolution and deconvolution operations. Extensive experiments verify the proposed method with competitive accuracies compared to state-of-the-art object detectors and other task-specific networks. LidarMTL is also leveraged for online localization. Code and pre-trained model have been made available at https://github.com/frankfengdi/LidarMTL.
Facile and benign conversion of sucrose to fructose using zeolites with balanced Brønsted and Lewis acidity (2017)

A simple and robust two-step process with zeolites as catalysts converts sucrose in high yield into the versatile monosaccharide fructose.
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors (2017)

Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site, located in the PA subunit, cleaves host mRNA to prime viral mRNA transcription, and is essential for viral replication. To date, the human influenza A endonuclease activity has only been studied on the truncated active-site containing N-terminal domain of PA (PAN) or full-length PA in the absence of PB1 or PB2. In this study, we characterized the endonuclease activity of recombinant proteins of influenza A/PR8 containing full length PA, PA/PB1 dimer, and PA/PB1/PB2 trimer, observing 8.3-, 265-, and 142-fold higher activity than PAN, respectively. Using the PA/PB1/PB2 trimer, we developed a robust endonuclease assay with a synthetic fluorogenic RNA substrate. The observed Km (150 ± 11 nM) and kcat [(1.4 ± 0.2) x 10-3s-1] values were consistent with previous reports using virion-derived replication complex. Two known influenza endonuclease phenylbutanoic acid inhibitors showed IC50 values of 10-20 nM, demonstrating the utility of this system for future high throughput screening.
Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney (2002)

Phagocytes generate superoxide anion (O(2)(-)) by a classic, 5-component NADPH oxidase. O(2)(-) contributes to hypertension in spontaneously hypertensive rats (SHR). Therefore, we tested the hypothesis that NADPH oxidase expression is enhanced in the SHR kidney. We also analyzed the localization of NADPH oxidase components in SHR kidney. Renal NADPH oxidase was quantified by reverse transcription-polymerase chain reaction and Western blotting and was localized in SHR and Wistar Kyoto rat (WKY) kidney by immunohistochemistry. The mRNA for 5 subunits of phagocyte NADPH oxidase, and also for MOX1 and RENOX (NOX4), was detected in adult rat kidney. Kidneys of adult (10 weeks old) SHR had a significantly (P<0.01) greater mRNA for p47phox (SHR 0.81 +/- 0.05 versus WKY 0.37 +/- 0.01, arbitrary unit), which was confirmed by Western blotting (SHR 0.58 +/- 0.04 versus WKY 0.42 +/- 0.04, arbitrary unit; P<0.05) and by immunohistochemistry. This higher p47phox protein expression was also detected in young prehypertensive SHR (SHR 0.61 +/- 0.05 versus WKY 0.39 +/- 0.04, arbitrary unit; P<0.01). The 10-week-old SHR contained more modest but significantly (P<0.05) greater protein for p67phox (SHR 0.54 +/- 0.02 versus WKY 0.46 +/- 0.02). Immunostaining localized p47phox, p67phox, and p22phox in vasculature, macula densa, distal convoluted tubule, cortical collecting duct, and outer and inner medullary collecting ducts. The kidney of SHR expresses genes for all the main components of phagocyte NADPH oxidase, RENOX, and MOX1. There is a prominent increase in the SHR kidney of the mRNA, and protein expression of p47phox in the vasculature, macula densa, and distal nephron, which precedes development of hypertension.