gebhart/patrepeval huggingface dataset:
Near-Infrared Emission Induced by Shortened Pt–Pt Contact: Diplatinum(II) Complexes with Pyridyl Pyrimidinato Cyclometalates (2019)

Four diplatinum(II) complexes with the formula [Pt(pypm)(μ-F<sup><i>n</i></sup>)]<sub>2</sub> (<b>2</b>, <b>3a</b>-<b>c</b>) bearing both a pyridine-pyrimidinate chelate and formamidinate bridge, where (pypm)H and F<sup><i>n</i></sup>H stand for 5-(pyridin-2-yl)-2-(trifluoromethyl)pyrimidine and functional formamidines with various substituents of <sup>i</sup>Pr (<i>n</i> = 1), Ph (<i>n</i> = 2), C<sub>6</sub>H<sub>4</sub><sup>t</sup>Bu (<i>n</i> = 3), and C<sub>6</sub>H<sub>4</sub>CF<sub>3</sub> (<i>n</i> = 4), were synthesized en route from a mononuclear intermediate represented by [Pt(pypm)Cl(F<sup>1</sup>H)] (<b>1</b>). Single-crystal X-ray diffraction studies confirmed the structure of <b>1</b> and <b>3a</b> comprised of an individual "Pt(pypm)" unit and two "Pt(pypm)" units with a Pt···Pt distance of 2.8845(2) Å, respectively. Therefore, in contrast to the structured emission of mononuclear <b>1</b> with the first vibronic peak wavelength at 475 nm, all other diplatinum complexes with shortened Pt···Pt separation exhibited greatly red shifted and structureless metal-metal to ligand charge transfer (MMLCT) emission that extended into the near-infrared region in solid states. Their photophysical characteristics were measured under three distinctive morphological states (i.e., crystals, sublimed powders, and vacuum-deposited thin films) by steady-state UV-vis spectroscopy, while retention of Pt···Pt interactions in deposited thin films of <b>2</b> and <b>3a</b>-<b>c</b> was confirmed using Raman spectroscopy, demonstrating lowered Pt···Pt stretching at 80-200 cm<sup>-1</sup>. Most importantly, complexes <b>3a</b>-<b>c</b> exhibited a gradual red shift with the trends crystals < sublimed powders < vacuum-deposited thin films, a result of increased intermolecular π-π stacking interactions and Pt···Pt interactions, while crystalline samples exhibited the highest luminescence among all three morphological states due to the fewest defects in comparison to other morphologies. Finally, <b>3b</b> was selected as a nondoped emitter for the fabrication of NIR-emitting OLEDs, giving an electroluminescence peak at 767 nm and a maximum external quantum efficiency of 0.14% with negligible roll-off.
Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway (2019)

ABSTRACT Quorum sensing is a bacterial communication process whereby bacteria produce, release and detect the accumulation of extracellular signaling molecules called autoinducers to coordinate collective behaviors. In Vibrio cholerae , the quorum-sensing autoinducer, DPO (3,5-dimethyl-pyrazin-2-ol), binds the receptor-transcription factor, VqmA. In response, the DPO-VqmA complex activates transcription of the vqmR gene encoding the VqmR small RNA. VqmR represses genes required for biofilm formation and virulence factor production. Here, we show that VqmA has DPO-dependent and DPO-independent activity. We solved the DPO-VqmA crystal structure and compared it to existing structures to understand the conformational changes the protein undergoes upon DNA binding. Analysis of DPO analogs reveals that a hydroxyl or carbonyl group at the 2’ position is critical for binding. The proposed DPO precursor, a linear molecule, Ala-AA (N-alanyl-aminoacetone), also binds and activates VqmA. DPO and Ala-AA occupy the same binding site as judged by site-directed mutagenesis and competitive ligand binding analyses.
Twenty‐Four‐Hour and Annual Variation in Onset of Epistaxis in Osler Disease (2007)

Osler disease is an autosomal dominant disorder of the fibrovascular tissue characterized by arteriovenous malformations with multi-systemic haemorrhages. Recurrent epistaxis is the predominant symptom in more than 90% of patients. Recent studies showed circadian and seasonal patterns in the onset of nosebleeds, similar to acute cardiovascular events, such as myocardial infarction and stroke. The aim of this study was to determine whether such patterns would also apply to the onset of epistaxis in patients with Osler disease. In all, 110 patients with Osler disease who were under treatment for recurrent epistaxis at the University Hospital of Mannheim were requested to complete a questionnaire addressing the intensity and frequency of epistaxis according to the classification of Bergler et al., as well as circadian and circannual rhythmicity in the occurrence of epistaxis according to visual analogue scales (VAS). More than half of the patients claimed to experience daily to weekly episodes of recurrent epistaxis. The occurrence of epistaxis showed a biphasic 24 h pattern, with a primary peak in the morning (05:00-8:00 h) and smaller secondary peaks in the evening (17:00-20:00 h and 21:00-00:00 h). No significant seasonal variation was found in the onset of epistaxis. However, a slight tendency, with a peak in winter months, was observed. Similar to other chronobiological studies on nosebleeds, this study showed that the 24 h pattern and seasonal tendency in the onset of epistaxis even applied to patients with Osler disease. Further investigations are necessary to determine the pathological mechanism underlying this phenomenon.
A thermal and process variation aware MTJ switching model and its applications in soft error analysis (2012)

Spin-transfer torque random access memory (STT-RAM) has recently gained increased attentions from circuit design and architecture societies. Although STT-RAM offers a good combination of small cell size, nanosecond access time and non-volatility for embedded memory applications, the reliability of STT-RAM is severely impacted by device variations and environmental disturbances. In this paper, we develop a compact switching model for magnetic tunneling junction (MTJ), which is the data storage device in STT-RAM cells. By leveraging the capability to simulate the impacts of thermal and process variations on MTJ switching, our model is able to analyze the diverse mechanisms of STT-RAM write operation failures. Besides the impacts of thermal and process variation, the soft error induced by radiation striking on the access transistor is another important threat to the MTJ reliability. It can also be analyzed by using our model. The incurred computation cost of our model is much less than the conventional macro-magnetic model, and hence, enabling its applications in comprehensive STT-RAM reliability analysis and design optimizations.
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Evaluation and Treatment of Infection at the Site of a Total Hip or Knee Arthroplasty*† (1998)

HANSSEN, ARLEN D. M.D.‡, ROCHESTER, MINNESOTA; RAND, JAMES A. M.D.§, SCOTTSDALE, ARIZONA Author Information
A1 The role of virus-antibody co-evolution in the development of a V3-glycan-directed HIV-1 broadly neutralizing antibody lineage (2019)

Abstract Broadly neutralizing antibodies (bNAbs) are essential for a preventative HIV-1 vaccine but have not been elicited through vaccination. bNAbs develop in 20–30 per cent of HIV-1 infections and often target the V3-glycan epitope of the HIV envelope protein (Env). In these individuals, virus-antibody co-evolution is thought to drive the maturation of antibody lineages to neutralization breadth. We used deep sequencing of env genes and antibody transcripts from fourteen time points spanning the first 3 years of infection to characterize the virus-antibody co-evolution in donor CAP255 who developed V3-glycan-specific bNAbs. Sequencing and cloning of env genes, followed by neutralization assays, were used to identify Env mutations associated with neutralization escape from two bNAbs (CAP255.G3 and CAP255.C5) isolated at 149 weeks post-infection (wpi). Sequencing data indicated that CAP255 was co-infected by three related viral variants, all of which had an intact N332 glycan, which persisted in &gt; 90 per cent of later viruses. A recombinant V3-region became fixed from 8 wpi, conferring slight neutralization resistance to CAP255.G3/C5 and other V3-glycan bNAbs. Later, T415R/K substitutions in V4 emerged by 51 wpi and were associated with complete viral escape from CAP255.G3/C5, though not from the polyclonal plasma response. All 93-week and later Envs were resistant to CAP255.G3/C5 and V3-glycan bNAb PGT135. Viral escape by 51 wpi suggested that the CAP255 bNAbs arose earlier, driving escape, but persisted to 149 weeks. This was supported by preliminary deep sequencing of the antibody repertoire that indicated bNAb lineage members were already present in the plasma at 39 wpi. Escape from V3-glycan bNAbs via T415R/K mutations have not previously been shown, suggesting a novel mode of recognition within the V3-glycan supersite. Further work will focus on identifying the bNAb-initiating Env and intermediate bNAb lineage members that were capable of engaging contemporaneous Env neutralization escape mutants. Characterization of Envs that engaged bNAb precursors, as well as those that selected for broader members of the bNAb lineage, will inform the design of immunogens capable of eliciting V3-glycan bNAbs in a novel HIV-1 vaccine regimen.
Cardiac and Noncardiac Atrial Natriuretic Factor (ANF) Biosynthesis and Storage and Plasma ANF in the Rat Model of Chronic Ventricular Dysfunction (1989)

To evaluate the role of atrial natriuretic factor (ANF) in chronic heart failure (HF), the biosynthesis and storage of ANF in cardiac and noncardiac tissues and the level of plasma ANF were measured in rats exhibiting minimal [2-fold rise in left ventricular end diastolic pressure; myocardial infarct (MI) scar length, 25% left ventricle (LV)] and moderate-severe (3-fold rise in left ventricular end diastolic pressure; decreased contractility (dp/dtmax); MI scar length, 47% LV) chronic HF 30 and 60 days after coronary arterial ligation. In rats with moderate-severe HF (30 days post-MI), the cardiac ANF mRNA concentration (determined by dot blot analysis) increased in three heart chambers [LV, 6-fold; left atria (LA), 3-fold; right ventricle (RV), 2-fold], cardiac immunoreactive ANF (IRANF; determined by RIA) concentration increased on the left side (LV, 7-fold; LA, 33%), but was unchanged (RV) or reduced on the right side (right atria, 33%), and plasma IRANF increased 3-fold above sham control values. Excluding the LV (used for MI scar length), the pattern and magnitude of change in ANF mRNA concentration in moderate-severe HF at 60 days were similar to those at 30 days; the cardiac IRANF concentration at this time was the same (LA) or less than (RV, 66%) sham values, and plasma IRANF increased 6-fold above respective sham values. Generally, the changes in the concentrations of cardiac ANF message and peptide and levels of circulating ANF peptide were smaller in rats with minimal HF. The minute quantities of ANF mRNA and IRANF detected in noncardiac tissues (lung, liver, pituitary, aortic arch, brain, kidney, and salivary gland) were unaltered by HF. These findings show that chronic HF, as defined by hemodynamic and histological measurements, specifically and continuously stimulates atrial as well as ventricular ANF biosynthesis; levels of plasma and cardiac ANF are increased early in HF, but with time are subject to modulation. The cardiac ANF system is the prime locus for the effects of HF, as noncardiac ANF biosynthesis and storage are undisturbed by chronic HF.
Dimers that Contain Unbridged W(IV)/W(IV) Double Bonds (2006)

Compounds that contain an unbridged WW bond can be prepared through bimolecular decomposition of various imido alkylidene complexes. One type of WW species is [W(NR)(CH2-t-Bu)(OR‘)]2 (R = 2,6-dimethylphenyl (Ar‘) or 2,6-diisopropylphenyl (Ar); R‘ = pentafluorophenyl or hexafluoroisopropyl), which is found in both heterochiral and homochiral forms. The other type is [W(NR)(OR‘)2]2 (R‘ = trifluoro-tert-butyl or hexafluoro-tert-butyl). All species contain an unbridged W(IV)/W(IV) double bond with a WW bond distance of 2.4−2.5 Å, a 90° angle between the imido ligands and the WW bond, and an anti relationship of the imido ligands. There is no indication that WW bonds are broken spontaneously; for example, heterochiral and homochiral [W(NR)(CH2-t-Bu)(OR‘)]2 species do not interconvert.
Measurement of the forward W boson cross-section in pp collisions at s = 7 $$ \sqrt{s}=7 $$ TeV (2014)

A measurement of the inclusive W production cross-section using data from pp collisions at a centre-of-mass energy of s = 7 TeV is presented. The analysis is based on an integrated luminosity of about 1.0 fb -1 recorded with the LHCb detector. Results are reported for muons with a transverse momentum greater than 20 GeV/c and pseudorapidity between 2.0 and 4.5. The W + and W -production cross-sections are measured to be W + + = 861.0 2.0 11.2 14.7 pb , W - - = 675.8 1.9 8.8 11.6 pb , where the first uncertainty is statistical, the second is systematic and the third is due to the luminosity determination. Cross-section ratios and differential distributions as functions of the muon pseudorapidity are also presented. The ratio of W + to W -cross-sections in the same fiducial kinematic region is determined to be
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 (2009)

The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of arthritis. Our efforts have resulted in the discovery of a series of carboxylic acid inhibitors of MMP-13 that do not significantly inhibit the related MMP-1 (collagenase-1) or tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE). It has previously been suggested (but not proven) that inhibition of the latter two enzymes could lead to side effects. A promising carboxylic acid lead 9 was identified and a convergent synthesis developed. This paper describes the optimization of 9 and the identification of a compound 24f for further development. Compound 24f is a subnanomolar inhibitor of MMP-13 (IC(50) value 0.5 nM and K(i) of 0.19 nM) having no activity against MMP-1 or TACE (IC(50) of >10000 nM). Furthermore, in a rat model of MMP-13-induced cartilage degradation, 24f significantly reduced proteoglycan release following oral dosing at 30 mg/kg (75% inhibition, p < 0.05) and at 10 mg/kg (40% inhibition, p < 0.05).
SDR Prototype for Clipped and Fast-Convolution Filtered OFDM for 5G New Radio Uplink (2020)

In wireless communications, higher transmission power enables higher coverage or higher data rate. However, due to hardware limitations, achieving high power efficiency becomes challenging. The main issue is that at high power region close to power amplifier (PA) saturation point the highly non-linear response of the PA leads to significant spectral regrowth. In such a case, waveforms with inherently good spectral containment allow for more spectral degradation and can be seen as the most effective solution for the problem. In this study, a fifth-generation new radio (5G NR) user equipment (UE) transmit power is improved by utilizing fast-convolution filtered orthogonal-frequency-division-multiplexing (FC-F-OFDM) waveform, which has an excellent spectral containment performance. A novel method is proposed for improving the peak-to-average-power ratio (PAPR) of FC-F-OFDM waveform, based on applying clipping before FC processing and allocating the clipping noise that stems from the applied clipping, over not only on active band, but a wider band consisting of both the in-band and guard-band regions. An accurate transmitter chain simulator including a measured memory-polynomial model of a practical PA is used to evaluate a wide set of different subcarrier spacings and channel bandwidths. Then, to validate the numerical results, a software-defined radio (SDR) based testbed is created and the modeled PA is used in this testbed. Weighted overlap-and-add (WOLA) based OFDM, also with clipping, is used as a reference in both the numerical evaluations and in measurements. For both waveforms, the transmitted signal quality, out-of-band emissions, and maximum PA output powers are measured under 5G NR specifications and results for different subcarrier spacings and channel bandwidths are provided to prove the benefits and robustness of the presented FC-F-OFDM approach.
Erratum: search for new physics in events with same-sign dileptons and b jets in pp collisions at $ \sqrt{s}=8 $ TeV (2013)

A search for new physics is performed using events with isolated same-sign leptons and at least two bottom-quark jets in the final state. Results are based on a sample of proton-proton collisions collected at a center-of-mass energy of 8 TeV with the CMS detector and corresponding to an integrated luminosity of 10.5 fb-1. No excess above the standard model background is observed. Upper limits are set on the number of events from non-standard-model sources and are used to constrain a number of new physics models. Information on acceptance and efficiencies is also provided so that the results can be used to confront an even broader class of new physics models. © 2013 CERN for the benefit of the CMS collaboration.
Interleukin-1 induced activation of nuclear factor- b can be inhibited by novel pharmacological agents in osteoarthritis (2007)

We have demonstrated that a novel pharmacological inhibitor of NF-kappaB, RO100 inhibits pathological mediators of OA progression with equivalent efficacy as established IL-1beta and TNF-alpha neutralizing strategies. Our findings highlight a potential for developing NF-kappaB targeted therapeutics for positively regulating disease activity and improving clinical outcome in OA.
Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study (2021)

The trial is registered at trialregister.nl (ID: NL8226) with the tag "DARTS".
Combinatorial Screening of Polymeric Sensing Materials Using RFID Sensors: Combined Effects of Plasticizers and Temperature (2009)

Recently, we have developed battery-free, passive RFID chemical and biological sensors that are attractive in diverse applications where sensor performance is needed at a low cost and when battery-free operation is critical. In this study, we apply this attractive low-cost sensing platform for the combinatorial screening of formulated sensing materials. As a model system, a 6 x 8 array of polymer-coated RFID sensors was constructed to study the combined effects of polymeric plasticizers and annealing temperature. A solid polymer electrolyte Nafion was formulated with five different phthalate plasticizers: dimethyl phthalate, butyl benzyl phthalate, di-(2-ethylhexyl) phthalate, dicapryl phthalate, and diisotridecyl phthalate. These sensing film formulations and control sensing films without a phthalate plasticizer were deposited onto 9-mm diameter RFID sensors, exposed to eight temperatures ranging from 40 to 140 degrees C using a gradient temperature heater, and evaluated for their response stability and gas-selectivity response patterns. This study demonstrated that our RFID-based sensing approach permits rapid cost-effective combinatorial screening of dielectric properties of sensing materials.
ERNEUERUNG DER LAENGSVORSPANNUNG BEI DEN INNBRUECKEN KUFSTEIN (1996)

Der Austausch des konzentrierten Spanngliedes war eine Bauaufgabe, die mit den Bereichen Spanngliedausbau, Sicherung der Zwischenzustaende und konstruktive Gestaltung der neuen Vorspannung ueber den gewohnten Erfahrungsbereich hinausging und letztlich die Entwicklung eines neuen Spanngliedtyps nach sich zog. Urspruenglich war der Spanngliedaustausch nur fuer das Bundesstrassentragwerk vorgesehen. Beim Abtrag des alten Spanngliedes wurden jedoch ausser der verursachenden Hauptschadstelle noch zahlreiche weitere Bereiche mit zum Teil erheblichem Rostbefall gefunden. Dies war letztlich die Veranlassung, auch bei den Autobahnbruecken den Spanngliedtausch vorzunehmen, weil bei gleichartiger Ausfuehrung der Spanngliedummantelung kein grundsaetzlich besserer Erhaltungszustand der Litzen angenommen werden konnte. Der spaetere Ausbau bei den Autobahntragwerken hat diese Annahme im wesentlichen bestaetigt. Der Austausch des konzentrierten Spanngliedes waere auch ohne den Schadensfall der Pfeilerunterkolkung notwendig gewesen. Die neue Vorspannung beim Bundesstrassentragwerk wurde wenige Tage vor dem Schadensereignis fertiggestellt. Die Entscheidung zur Fortsetzung dieses Sanierungsprogrammes bei den Autobahntragwerken war bereits gefallen. Allerdings ist festzuhalten, dass der Pfeilerschaden und seine Behebung auch fuer den Spanngliedtausch Erschwernisse und Konsequenzen brachte. Der Spanngliedtausch kann, wie beim Tragwerk der Bundesstrasse gezeigt wurde, grundsaetzlich auch unter massvoll eingeschraenktem Verkehr erfolgen. Bei den Autobahntragwerken wurde jedoch die Moeglichkeit, das jeweils bearbeitete Tragwerk verkehrsfrei zu halten, mit Vorteil ausgenuetzt.
An Ica-Based Rfs Approach For Doa Tracking Of Unknown Time-Varying Number Of Sources (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Reconfigurable RF-MEMS Metamaterials Filters (2011)

In this work, the design procedure, modelling and implementation of reconflgurable fllters based on RF microelectromechanical systems metamaterials is presented. Speciflcally, tunable stop-band and pass-band frequency responses are obtained by combining RF-MEMS with metamaterials based in complementary split rings resonators. These particles, allow for the design of negative efiective permittivity transmission lines, providing forbidden propagation frequency bands. Moreover, CSRRs properly combined with metal vias in transmission lines, generate a simultaneously < 0 and < 0 efiective media which involves an allowed frequency band. These two phenomenons have been used in order to implement stop-band and pass-band fllters. Since CSRRs present a LC-tank behaviour and are electrically coupled to the host line, the tunability is achieved by means of the RF-MEMS, which modify the electrical characteristics of the CSRRs and the electric coupling. A full electrical model for the description of the proposed structures is presented. The circuit model take into account the electrical characteristics of the RF-MEMS, CSRRs and transmission lines as well as the involved electromagnetic coupling and are used for accurate prediction of switchable fllters response.