gebhart/patrepeval huggingface dataset:
An Analysis of the Ecology Fabric Trend : 20 Years(1986-2005) of S/S Woven Fabric Trends (2010)

In order to provide more systematic approach to analyze fabric trends and to develop fabrics accordingly, ecology fabric trend from 1986 to 2005 was analyzed related with fabric trend themes and fabric attributes. The result shows that in the 1980s, natural theme appeared, followed by primitive theme and imitated natural theme until the mid 1990s. From the late 1990s to the early 2ooos, new natural theme appeared followed by eco-friendly theme, and then recycling theme. In the natural theme, `clean` was the most important fabric attribute and `textured` and `worn` were important fabric attributes in the primitive theme. In the imitated natural theme, `wet` fabric attribute was preferred In the new natural theme, `lightweight` were preferred The results of this study empirically demonstrated that abstract and ambiguous trend terms can be interpreted with a physical, substantial, and feasible attributes that fabric practitioners can easily understand.
High-Accuracy Proximity Effect Correction for Mask Writing (2007)

A high-accuracy proximity effect correction method for high-precision masks has been developed to satisfy current and future requirements. In this paper, we explain the primary features of this method and the theories on which it is based. The developed formula for obtaining the optimum correction dose is expressed in the form of either iterations or an infinite series of functions. The advantage of this formula is that it quickly converges to the sought value, bringing about high-accuracy proximity effect correction with a high calculation speed. A coarse graining method (covering pattern density and representative figure methods) for reducing calculation time is explained. This method has been adopted for an EX-11 series and has been used for mask writing from the 180 nm design rule onward.
Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin (2007)

Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of huntingtin is generated. Heat shock protein 70 (HSP70) prevents the formation of protein aggregates, but the effect of HSP70 on the huntingtin in the endosome-lysosomal system is unknown. This study was to determine whether HSP70 alters the distribution of huntingtin in endosome-lysosomal system. HSP70 expressing stable cells (NIH/3T3 or cerebral hybrid cell line A1) were generated, and mutant [(CAG)(100)] huntingtin was transiently overexpressed. Analysis of subcellular distribution by immunocytochemistry or proteolysis cleavage by Western blotting was performed. 18 CAG repeat wild type [WT; (CAG)(18)] huntingtin was used as a control. Cells with huntingtin showed patterns of endosome-lysosomal accumulation, from a "dispersed vacuole (DV)" type into a coalescent "perinuclear vacuole (PV)" type over time. In WT huntingtin, HSP70 increased the cells with the PV types that enhanced the proteolytic cleavage of huntingtin. However, HSP70 reduced cells of the DV and PV types expressing mutant huntingtin, that result in less proteolysis than that of control. In addition, intranuclear inclusions were formed only in mutant cells, which was not affected by HSP70. These results suggest that HSP70 alters the distribution of huntingtin in the endosome- lysosomal system, and that this contributes to huntingtin proteolysis.
PI-31Genotype frequencies for ten polymorphisms of the renin-angiotensin-aldosterone system between healthy French-Canadians and other ethnic groups (2006)

BACKGROUND/AIMS Differences exist in frequencies of certain genotypes within different populations. We analysed the polymorphism frequency of ten polymorphisms of the RAAS in our population and compared them to other ethnic groups. METHODS This is an observational study performed on 18 to 25 years old 200 healthy males of French-Canadian origin. The Gen Elute Blood Genomic DNA kit (Sigma PC# NA2020) was used to extract DNA. The studied polymorphisms were: ACE I/D, ATR1 A1166C, AGT M235T, AGT T174M, CYP11B2 T-344C, α-adducin G460W, beta-2 adrenergic receptor Q27E, bradykinin β2R +9/-9, eNOS T-786C and eNOS E298D. They were analysed by the standard PCR/enzymatic digestion/electrophoresis method. RESULTS All polymorphisms tested were in Hardy-Weinberg equilibrium. When compared to other ethnic groups, our population's genotype frequencies differed from the Asian and the African-American populations with respect to every polymorphism, except for the bradykinin β2R gene (data was unavailable) and differed from the African population with respect to the polymorphism of ACE, AGT235, AGT174 and CYP11B2. When compared with other Caucasian populations, we obtained different genotype frequencies for the ATR1, AGT235, beta-2 adrenergic receptor, eNOS-786 and eNOS298 genes. CONCLUSION Our study depicts the genetic profile of ten polymorphisms of the RAAS in French-Canadian healthy man. We noted differences in that profile when compared to Africans, African-Americans, Asians and other Caucasians. Clinical Pharmacology & Therapeutics (2005) 79, P15–P15; doi: 10.1016/j.clpt.2005.12.052
Cadaveric Renal Transplantation: Surgical Results and Expectations in the cyclosporine Era (1988)

During a 36-month period 100 patients received 104 cadaveric renal transplants with cyclosporine-based immunosuppression. Of the patients 26 required 31 additional operations. Of the 19 secondary operations performed 1 month after transplantation 18 were emergency in nature, whereas beyond this period the majority of the procedures were elective. Both deaths in this series were related to the operation. Only 1 graft loss was directly attributed to a secondary operation. The patient undergoing cadaveric renal transplantation is at significant risk (25 per cent) of requiring at least 1 additional operation. However, despite this high probability of reoperation, graft loss and patient death after such procedures should be rare.
Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation (2014)

According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.
VARIATION IN IMAGING UTILIZATION FOR URINARY LITHIASIS IN THE UNITED STATES (2009)

You have accessJournal of Urology1 Apr 2009VARIATION IN IMAGING UTILIZATION FOR URINARY LITHIASIS IN THE UNITED STATES Charles D Scales, Alisa M Shea, Lesley H. Curtis, Michael N Ferrandino, Dorit E Zilberman, Kevin A Schulman, and Glenn M. Preminger Charles D ScalesCharles D Scales More articles by this author , Alisa M SheaAlisa M Shea More articles by this author , Lesley H. CurtisLesley H. Curtis More articles by this author , Michael N FerrandinoMichael N Ferrandino More articles by this author , Dorit E ZilbermanDorit E Zilberman More articles by this author , Kevin A SchulmanKevin A Schulman More articles by this author , and Glenn M. PremingerGlenn M. Preminger More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60213-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "VARIATION IN IMAGING UTILIZATION FOR URINARY LITHIASIS IN THE UNITED STATES." The Journal of Urology, 181(4S), pp. 73–74 © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byRouth J, Graham D and Nelson C (2010) Trends in Imaging and Surgical Management of Pediatric Urolithiasis at American Pediatric HospitalsJournal of Urology, VOL. 184, NO. 4S, (1816-1822), Online publication date: 1-Oct-2010. Volume 181Issue 4SApril 2009Page: 73-74 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Charles D Scales More articles by this author Alisa M Shea More articles by this author Lesley H. Curtis More articles by this author Michael N Ferrandino More articles by this author Dorit E Zilberman More articles by this author Kevin A Schulman More articles by this author Glenn M. Preminger More articles by this author Expand All Advertisement PDF downloadLoading ...
Health care application of gas sensors (2015)

For the research goal of exhaled breath detection system in human health care or medical application, gas-selective and sensitive gas sensors have been developed. High performance sensors satisfying the boundary conditions, such as fast response and highly sensitive and selective detection, were developed with three essential components of a novel working principle, nanoparticle technology, and a ceramic integration process of sensing materials.
Kvælstofmanagement på store økologiske kvægbrug (2009)

Store økologiske besætninger kræver meget kløvergræs tæt på gården. Udnyttelse og tab af kvælstof i disse græsintensive sædskifter kan kontrolleres af management. I græsmarken kan afgræsningsperioden eller gødningstilførsel reduceres, og efter ompløjning af græs kan grønbyg med italiensk rajgræs reducere udvaskningen til at minimum.
Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma (2017)

[This corrects the article DOI: 10.1371/journal.pone.0158888.].
High-accuracy microdrilling of steel with solid state UV laser at a rate of 10 mm/sec (2000)

We investigated wavelength- and intensity-dependence of ablation rate achievable with a diode-pumped Q-switched Nd:YAG laser with frequency doubling and tripling. The laser produced 15 ns-long pulses at a repetition rate of 10 kHz and output power of 28 W in the fundamental beam, and 15 W and 10 W in the second and third harmonics, respectively. We found that in thin stainless and carbon steel foils, fast ablation starts at the laser fluence level of 10 J/cm<SUP>2</SUP>. The ablation rate remains close to 1 micrometers per pulse with very little change as the laser fluence increases by more than order of magnitude above this threshold exit of the hole. This attenuation is strongly dependent on the laser wavelength. Particularly, using third harmonic output, we were able to sustain average drilling speed of more than 1 micrometers per pulse in samples up to 1 mm thick. At the same time, removal rate at fundamental wavelength decreased by almost an order of magnitude.
Adsorptive and passive pinocytic uptake (1980)

Many different terms have been employed to describe different types of endocytosis, and these are listed by Chapman-Andresen (1962) and Jacques (1969), but in general endocytic phenomena fall into two broad categories, phagocytosis and pinocytosis. Phagocytosis describes the ingestion of particulate matter such as bacteria, latex beads and erythrocytes by specialised cells such as macrophages and certain unicellular organisms, whereas the more universal process of pinocytosis describes the engulfment of small droplets of extracellular fluid.
Phenolic Content and Antioxidant Properties of Bran in 51 Wheat Cultivars (2008)

ABSTRACT Whole‐grain‐based diets have been suggested to reduce the incidence of cardiovascular disease and colon cancer. Phenolic compounds, most of which are present in the wheat bran, may be one of the factors contributing to whole‐grain health benefits. We measured the free, bound, and total phenolic content and antioxidant activity in the bran of 51 wheat cultivars belonging to eight Western Canadian spring wheat market classes grown in a replicated trial at Saskatoon, Saskatchewan, Canada. The free phenolic (extracted with 80% v/v aqueous ethanol) content ranged from 854.1 ± 265.1 to 1,754.9 ± 240.3 μg/g of bran gallic acid equivalent (GAE). Saponification followed by a liquid‐liquid solvent extraction released bound phenols ranging from 2,304.9 ± 483.0 to 5,386.1 ± 927.5 μg/g of bran GAE, contributing 66–82% of the total wheat bran phenolic content. Total phenolic content ranged from 3,406.4 ± 32.3 to 6,702.7 ± 19.6 μg/g of bran GAE, with the average being 5,197.2 ± 804.9 μg/g of bran GAE. Antioxidant activity ranged from 11.86 ± 2.59 to 20.12 ± 0.51%, while the overall average was 15.6 ± 2.2%. Based on varietal means, antioxidant activity correlated with free, bound, and total phenolic content ( r = 0.8, P &lt; 0.05).
Data Supplement from Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial (2023)

&lt;p&gt;Supplementary Table 2. Genes included in the sorafenib sensitivity signature.&lt;/p&gt;
SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells (2018)

Signaling via estrogen receptors (ER) is recognized as an essential part of the immune regulation, and ER-mediated signaling is involved in autoimmune reactions. Especially ERα activation in immune cells has been suggested to skew cytokine production toward Th2/M2-type mediators, which can have protective effect on inflammatory diseases and reduce Th1 and Th17 responses. These effects are caused by increased alternative activation of macrophages and changes in the activation of different T cell populations. In humans, hormonal status has been shown to have a major impact on several inflammatory diseases. Selective estrogen receptor modulators (SERMs) are ER ligands that regulate ER actions in a tissue-specific manner mostly lacking the adverse effects of steroid hormones. The impact of SERMs on the immune system is less studied, but it is suggested that certain SERMs may also produce immunoprotective effects. Here, we show that two novel SERMs and raloxifene affect immune cells by promoting M2 macrophage phenotype, alleviating NFκB activity, inhibiting T cell proliferation, and stimulating the production of anti-inflammatory compounds such as IL10 and IL1 receptor antagonist. Thus, these compounds have high potency as drug candidates against autoimmune diseases.
The 1918 Influenza Pandemic: Lessons from the Past Raise Questions for the Future (2008)

The ‘Spanish’ influenza pandemic of 1918-1919 was the most severe in recorded history, affecting approximately 25% of the world’s population and killing in the order of 50 million people. Subsequent influenza pandemics of the 20th century have been less severe. An understanding of the mechanisms underlying the severity of the 1918 pandemic could potentially help to reduce the extent of future pandemics. To this end, the entire 1918 virus and viruses bearing combinations of 1918 genes have been reconstructed through reverse genetics techniques. The availability of a viable 1918 strain has enabled researchers to investigate the viral and host factors underlying the extreme pathogenicity of the 1918 virus. These studies and others have revealed many features regarding the unusual epidemiology, pathogenicity, replication and transmission of the 1918 virus, and aid us in predicting the severity of future pandemic outbreaks.
Adiponectin receptor activation with AdipoRon prevents Truvada-induced microvascular oxidative stress and dysfunction in mice (2023)

Background: Persons living with the human immunodeficiency virus (PLHIV) and treated with anti-retroviral therapy such as emtricitabine and tenofovir disoproxil fumarate (Truvada, TVD) have increased cardiovascular risk but the mehcamisms and management are unclear. Since we found that PLHIV treated with antiretroviral drugs including TVD had significantly (P&lt;0.05) decreased adiponectin in plasma (3.3±0.3 vs 4.5±0.5 μg · mL -1 ) and in perivascular adipose tissue (14±1 vs 22±2 μg·mg protein -1 ·mL -1 ), we tested the hypothesis that impaired adiponectin signaling with TVD causes microvascular dysfunction. Methods: CB57Bl/6 mice (n=6-8/ group) were administered vehicle (Veh), TVD (30 mg/kg/day), AdipoRon (ADR; adiponectin receptor agonist; 50 ug/kg/day) or both orally for 28 days. Mesenteric resistance arterioles were studied on isometric myographs and microvascular nitric oxide (NO) and reactive oxygen species (ROS) by RatioMaster. Results: TVD significantly (P&lt;0.05) increased malondialdehyde in serum (50±5 vs 17±2 μM) and in urine (59±15 vs 7±3 μM), urine albumin/creatinine ratio (0.9±0.1 vs 0.04±0.0), microvascular contractions to U-46,619 (98± vs 88±3%; P&lt;0.05) and endothelin-1 (83± vs 69±3%), cellular ROS (DHE: 0.29±0.03 vs 0.15±0.04 unit) and mitochondrial ROS (mitotempo: 0.25±0.04 vs 0.12±0.03 unit) and reduced endothelium-dependent relaxation (48± vs 81±3%) and NO (0.28±0.03 vs 0.42±0.07 units). ADR alone did not alter these measurements but significantly (P&lt;0.05) prevented all of these effects of TVD. Conclusions: Activation of adiponectin receptors prevents the systemic and microvascular oxidative stress, microvascular endothelial dysfunction and NO deficiency and enhanced contractility caused by one month of TVD. Therefore, AdipoRon may mitigate the excess cardiovascular disease of PLHIV who are receiving Truvada. NIH National Heart, Lung, and Blood Institute, NIH 5RO1-HL134511 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
ChemInform Abstract: Mass Transport in Supported Zinc Halide Solutions. Part 2. Complexation and Migration Effects. (1986)

Abstract In ZnCIZ/KCI‐Lösungen ist ZnCl; die vorherrschende Zn‐ Spezies.
CotH3 mediates fungal invasion of host cells during mucormycosis (2013)

Angioinvasion is a hallmark of mucormycosis. Previously, we identified endothelial cell glucose-regulated protein 78 (GRP78) as a receptor for Mucorales that mediates host cell invasion. Here we determined that spore coat protein homologs (CotH) of Mucorales act as fungal ligands for GRP78. CotH proteins were widely present in Mucorales and absent from noninvasive pathogens. Heterologous expression of CotH3 and CotH2 in Saccharomyces cerevisiae conferred the ability to invade host cells via binding to GRP78. Homology modeling and computational docking studies indicated structurally compatible interactions between GRP78 and both CotH3 and CotH2. A mutant of Rhizopus oryzae, the most common cause of mucormycosis, with reduced CotH expression was impaired for invading and damaging endothelial cells and CHO cells overexpressing GRP78. This strain also exhibited reduced virulence in a diabetic ketoacidotic (DKA) mouse model of mucormycosis. Treatment with anti-CotH Abs abolished the ability of R. oryzae to invade host cells and protected DKA mice from mucormycosis. The presence of CotH in Mucorales explained the specific susceptibility of DKA patients, who have increased GRP78 levels, to mucormycosis. Together, these data indicate that CotH3 and CotH2 function as invasins that interact with host cell GRP78 to mediate pathogenic host-cell interactions and identify CotH as a promising therapeutic target for mucormycosis.
L'historiographie des Lumières en Belgique (XIXe -XXe siècle): tendances et grands enjeux idéologiques (1995)

info:eu-repo/semantics/published
Network Based Technology Roadmapping for Future Markets: Case of 3D Printing (2014)

A clear and understandable Technology Roadmap (TRM) is necessary to planning and navigating change in the product development process. The fabric of the 3D printing landscape is complex and difficult to understand from single snapshot approach and a TRM is only as useful as it is understandable and easily communicable. Successful Technology Roadmapping involves expert industry analysis, technology expertise, and visual story telling. This research builds upon the principles of existing Technology Roadmapping practices to develop models that apply to the consumer market of the 3D content-to-print industry. In managing the involved complexity, multiple tools and methods have been explored, focusing on the efficacy and legibility of TRM’s. Literature review, analysis of market forces, patent analysis, and quality functional deployment (QFD) were used to establish current and future market drivers and subsequent product features. Technology forecasting and scenario analysis were then used to create product portfolios for 3D content manufactures. The application and research explored creating two future product scenario’s; a low cost (LC) product that would maintain the current state of the art performance metrics tailored to the mass market consumer and a high performance (HP) product that would continue to push the capability of the at home manufacturing performance. These bifurcating foci further complicate the visual illustration of these roadmaps. An exercise in visual display of a large blanket of networks and relationships has led to a powerful tool used to identify future reach and impacts of early technological investments.
Sensitive Serology Measurements in the Saliva of Individuals with COVID-19 Symptoms Using a Multiplexed Immunoassay (2022)

This study shows that our multiplexed immunoassay can distinguish infected from uninfected individuals and reliably (93.3% specificity) detect seroconversion (in 60% of infected individuals) as early as the first week PSO, using easy-to-collect saliva samples.
Magnetic Resonance Imaging of Benign Spinal Lesions Simulating Metastasis: Role of Diffusion-Weighted Imaging (2000)

In an attempt to avoid unnecessary therapy, this article demonstrates benign vertebral body lesions that mimic metastatic disease in cancer patients with back pain. The magnetic resonance imaging features that aid in differential diagnosis are demonstrated. In addition, the value of diffusion-weighted spinal imaging to further aid in distinguishing benign from malignant disease is described.
Synthesis Of Asymmetric S, S, S-Trialkyl Phosphorotrithioates (1977)

Abstract Recently we described the new synthesis of S-alkyl phosphorothioates from the corresponding phosphoroanilidates and established the stereochemistry of cleavage of P-N bond in P-chiral anilidates 1. We also demonstrated that P-N→P-S conversion can be succesfully applied to the synthesis of P-enantiomeric 3′-thymidine O-o-chlorophenyl phosphorothioates 2.
Human Dendritic Cells Presenting Adenovirally Expressed Antigen Elicit Mycobacterium tuberculosis –Specific CD8 + T Cells (2002)

Previous studies in murine and human models have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). Consequently, a successful tuberculosis vaccine may require the elicitation of sustained CD4+ and CD8+ T cell responses. We tested the hypothesis that the potent CD4+ T cell antigen Mtb39 is also a CD8+ T cell antigen. A recombinant adenovirus-expressing Mtb39 (adenoMtb39) was used to infect monocyte-derived dendritic cells. Using interferon-gamma enzyme-linked immunospot, Mtb39-specific CD8+ T lymphocytes were detected in three healthy individuals with latent tuberculosis infection who also had strong anti-Mtb39-specific CD4+ T cell responses. An Mtb39-specific CD8+ T cell line was generated using Mtb39-expressing dendritic cells. Mtb39-specific T cell clones were obtained by limiting dilution cloning. All seven T cell clones obtained were HLA-B44 restricted. Using a panel of synthetic overlapping peptides representative of Mtb39, the peptide epitope was identified for two clones. Furthermore, all T cell clones recognized Mtb-infected dendritic cells and were cytolytic. We conclude that infection of dendritic cells with adenoviral vectors expressing Mtb proteins allows for measurement of antigen-specific CD8+ T cell responses from peripheral blood mononuclear cells. The technique will be useful in defining CD8+ T cell antigens and in measuring immunogenicity of tuberculosis vaccines.