gebhart/patrepeval huggingface dataset:
Papers Presented at the Hip Society Meetings 2006 (2006)

The 2006 Papers Presented at the Hip Society contains papers read at the 2005 Annual Closed Fall Meeting of the Hip Society, held in Pittsburgh, and the 2006 Open Scientific Winter Meeting of the Hip Society, held in Chicago. The subject matter within this symposium is due to the excellent organization of these two annual scientific meetings by William Capello, MD and James D'Antonio, MD. The entire spectrum of hip arthroplasty is covered by including topics such as prevention of venous thromboembolism, assessment and treatment of osteolysis, use of alternative bearing surfaces, aspects of hip resurfacing and minimally invasive hip surgery, long-term results of primary femoral fixation, prevention and management of hip instability, and treatment of difficult acetabular and femoral revision procedures. Several papers discussing pain management and the use of computer navigation provide a window into topics that are likely to expand significantly over the next several years. Since it is expected that the number of primary hip arthroplasties is expected to continue to increase annually, articles describing excellent long-term fixation of several uncemented femoral components and the ongoing efforts to avoid bone loss with the use of newer bearing surfaces are relevant to the durability of these primary arthroplasties. The early results of alternative treatment approaches such as hip resurfacing, which has enjoyed renewed interest using alternative bearing surfaces, appears to be an area that will be followed for some time as these implants are being preferentially implanted in younger and more active patients. Despite these technological efforts to avoid implant failure, the annual revision burden is expected to continue to substantially increase. The encouraging results of new approaches toward acetabular revision, excellent fixation of several revision femoral components, and viable treatment options for extremely difficult clinical scenarios such as pelvic discontinuity and prior pelvic irradiation are likely to be helpful for many readers. It must be remembered that true advances in technology and medical care are ultimately determined by rigorous scientific study, analysis, and a peer reviewed process. This rather slow and stepwise scientific approach is in direct contrast to the ever increasing prevalence of immediate marketing and proclamation without an assessment of patient outcomes based on scientific study. The primary goals of the Hip Society include advancement of knowledge of the hip joint in health and in distress and provision for a forum to stimulate exchange of knowledge concerning education, research, and treatment of disorders of the hip. Hopefully this symposium demonstrates the successful efforts of the Hip Society to address the many aspects of hip replacement with rigorous scientific study. Arlen Hanssen, MD Department of Orthopaedics, Mayo Clinic Rochester, MN; and Deputy Editor of the Hip Society Clinical Orthopaedics and Related Research Philadelphia, PA
Interleukin-1β deficiency results in reduced NF-κB levels in pregnant mice (2000)

Interleukin (IL)-1beta-deficient (IL-1beta(-/-)) mice were assessed for cytokine production during pregnancy. A significant reduction in nuclear factor (NF)-kappaB p65 protein content was observed in the uteri and spleens of pregnant IL-1beta(-/-) mice, as demonstrated by immunohistochemistry and Western immunoblot analysis. In addition, electromobility gel shift assay revealed less DNA binding activity of NF-kappaB p65-containing complex in pregnant IL-1beta(-/-) mice. To investigate differences in cytokine production regulated by NF-kappaB, the levels of tumor necrosis factor-alpha, macrophage inflammatory protein-1alpha, and interferon-gamma were measured in the uterine wall, spleen homogenates, and spleen cell cultures obtained from pregnant mice. Endocervical administration of lipopolysaccharide (LPS) increased cytokine levels in both wild-type (IL-1beta(+/+)) and IL-1beta(-/-) animals, but in IL-1beta(-/-) mice this response was 50-75% lower. Splenocytes from nonpregnant mice exhibited decreased LPS-induced cytokine production when primed in vitro with progesterone. This suppression was 25% greater in IL-1beta(-/-) than in IL-1beta(+/+) mice. These data suggest that constitutive NF-kappaB p65 protein synthesis is regulated by IL-1beta, particularly during pregnancy.
Organic Solar Cells: All‐Inkjet‐Printed, All‐Air‐Processed Solar Cells (Adv. Energy Mater. 14/2014) (2014)

All-inkjet-printed, all-air-processed organic solar cells with an average power conversion efficiency of 2% are demonstrated for the first time. Highly efficient, printed solar cells (5%) with a simple three-layer structure whose cathode is the only non-printed layer are also demonstrated. As reported by Sungjune Jung, Henning Sirringhaus, and co-workers in article number 1400432, the results show that inkjet-printing is an attractive digital printing technology for cost-effective, environmentally friendly integration of photovoltaic cells onto plastic substrates.
DISLOCATION IN LATERAL UNICOMPARTMENTAL ARTHROPLASTY, AN IN-VITRO CADEVERIC STUDY (2004)

When the Oxford unicompartmental meniscal bearing arthroplasty (UCA) is used in the lateral compartment of the knee 10% of the bearings dislocate. An in-vitro cadaveric study was performed to investigate if the anatomy and joint geometry of the lateral compartment was a contributory factor in bearing dislocation. More specifically, the study investigated if the soft tissue tension of the lateral compartment, as determined by the length of the lateral collateral ligament (LCL), was related to bearing dislocation. A change in length of greater than 2 mm is sufficient to allow the bearing to dislocate. The Vicon Motion Analysis System (Oxford Metrics, Oxford, UK) was used to assess length changes in the LCL of seven cadaveric knees. Measurements were made of the LCL length through knee flexion and of the change in LCL length when a varus force was applied at a fixed flexion angle. Measurements were made in the normal knee and with the knee implanted with the Oxford prosthesis. In the intact knee the mean LCL change was 5.5mm (8%) over the flexion range. After implantation with the Oxford UCA the mean change in length was only 1 mm (1%). There was a significant difference in the LCL length at 90° (p=0.03) and 135° (p=0.01) of knee flexion compared to the intact knee. When a varus force was applied the LCL length change of the intact knee (5.4 mm) was significantly different (p=0.02) to that of the knee with the prosthesis implanted (2.7 mm) This study used a new method to dynamically measure LCL length. It found that after implantation of the Oxford lateral UCA the LCL remains isometric over the flexion range and does not slacken in flexion as it in the normal knee. This would suggest that the soft tissue tension was adequate to contain the bearing within the joint. However, when a varus force was applied the LCL did not sufficiently resist a displacing force producing an LCL length change greater than 2 mm. The evidence provided by this study is contradictory. The “lack of change in LCL length through flexion” suggests that the ligament remains tight through range and is unlikely to allow dislocation. However, the amount of distraction possible when an adducting moment is applied is sufficient to allow bearing dislocation. The length tension properties of the lateral structures are therefore implicated in the mechanism of dislocation.
An assessment of wide bandgap semiconductors for power devices (2003)

An advantage for some wide bandgap materials, that is often overlooked, is that the thermal coefficient of expansion (CTE) is better matched to the ceramics in use for packaging technology. It is shown that the optimal choice for uni-polar devices is clearly GaN. It is further shown that the future optimal choice for bipolar devices is C (diamond) owing to the large bandgap, high thermal conductivity, and large electron and hole mobilities. A new expression relating the critical electric field for breakdown in abrupt junctions to the material bandgap energy is derived and is further used to derive new expressions for specific on-resistance in power semiconductor devices. These new expressions are compared to the previous literature and the efficacy of specific power devices, such as heterojunction MOSFETs, using GaN are discussed.
Single disperser design for compressive, single-snapshot spectral imaging (2007)

Recent theoretical work in "compressed sensing" can be exploited to guide the design of accurate, single-snapshot, static, high-throughput spectral imaging systems. A spectral imager provides a three-dimensional data cube in which the spatial information of the image is complemented by spectral information about each spatial location. In this paper, compressive, single-snapshot spectral imaging is accomplished via a novel static design consisting of a coded input aperture, a single dispersive element and a detector. The proposed "single disperser" design described here mixes spatial and spectral information on the detector by measuring coded projections of the spectral datacube that are induced by the coded input aperture. The single disperser uses fewer optical elements and requires simpler optical alignment than our dual disperser design. We discuss the prototype instrument, the reconstruction algorithm used to generate accurate estimates of the spectral datacubes, and associated experimental results.
Study on Predicting Formula for Torsional Fatigue Strength of Spring Steel (2007)

Torsional fatigue tests were conducted for spring steel SUP7 with smooth surface and artificial pits whose Vickers hardness were 430,480,550 and 620. The effect of notch, hardness and corrosive environment on the fatigue strength was studied. Following conclusions were obtained. (1) The relationship between torsional fatigue strength and hardness in the specimen with smooth surface in air environment was not linear and approximated by third function of hardness revealing the maximum value around 550Hv. (2) The notch factor of torsional fatigue strength in the specimen with artificial pits was the constant value of 1.7 with no relation to hardness and fatigue life in air environment. (3) The notch factor of torsional fatigue strength in the specimen with artificial pits was decreased with the increment of hardness approaching to the value of 1 for long-term fatigue life in corrosive environment. (4) The empirical formulas were derived indicating the fatigue strength in the specimen with artificial pits, the corrosive fatigue strength in the specimen with smooth surface, and the corrosive fatigue strength in the specimen with artificial pits by the third function of hardness.
Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73 (1998)

p73 is a recently identified member of the p53 family. Previously it was shown that p73 can, when overproduced in p53-defective tumor cells, activate p53-responsive promoters and induce apoptosis. In this report we describe the generation of anti-p73 monoclonal antibodies and confirm that two previously described p73 isoforms are produced in mammalian cells. Furthermore, we show that these two isoforms can bind to canonical p53 DNA-binding sites in electrophoretic mobility shift assays. Despite the high degree of similarity between p53 and p73, we found that adenovirus E1B 55K, simian virus 40 T, and human papillomavirus E6 do not physically interact with p73. The observation that viral oncoproteins discriminate between p53 and p73 suggests that the functions of these two proteins may differ under physiological conditions. Furthermore, they suggest that inactivation of p73 may not be required for transformation.
Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips (2012)

We used the recently introduced "metabolomics-on-a-chip" approach to test secondary drug toxicity in bioartificial organs. Bioartificial organs cultivated in microfluidic culture conditions provide a beneficial environment, in which the cellular cytoprotective mechanisms are enhanced, compared with Petri dish culture conditions. We investigated the metabolic response of HepG2/C3a cells exposed to flutamide, an anticancer prodrug, and hydroxyflutamide (HF), its active metabolite, in a microfluidic biochip. The cellular response was analyzed by (1)H nuclear magnetic resonance spectroscopy to identify cell-specific molecule-response markers. The metabolic response to flutamide results in a disruption of glucose homeostasis and in mitochondrial dysfunctions. This flutamide-specific metabolic response was illustrated by a reduction of the extracellular glucose and fructose consumptions and a general reduction of the tricarboxylic acid cycle activity leading to the reduction of the consumption of several amino acids. We also found a higher production of 3-hydroxybutyrate and lactate, and the reduction of the albumin production compared with controls. The toxic metabolic signature associated with the active metabolite HF was illustrated by a high-energy demand and an increase in several amino acid metabolism. Finally, for both molecules, the hepatotoxicity was correlated to the glutathione (GSH) metabolism illustrated by the levels of the 2-hydroxybutyrate and pyroglutamate productions and the increase of the glutamate and glycine productions. Thus, the entire set of results contributed to extract specific mechanistic toxic signatures and their relation to hepatotoxicity, which appeared consistent with literature reports. As new finding of HepG2/C3a cells hepatotoxicity, we propose a metabolic network with a related list of metabolite variations to describe the GSH depletion when followed by a cell death for the HepG2/C3a cells cultivated in our polydimethylsiloxane microfluidic biochips. Our findings illustrate the potential of metabolomics-on-a-chip as an in vitro alternative method for predictive toxicology.
Bax accelerates staurosporine-induced but suppresses nigericin-induced neuronal cell death (1997)

Bax, a member of the Bcl-2 multigene family, is known to promote apoptosis. To investigate the role of Bax in an experimentally induced cell death of the murine dopaminergic neuronal cell line (MN9D), we established MN9D cells stably over-expressing murine Bax (MN9D/ Bax) or vector alone (MN9D/Neo). In MN9D/Neo cells treated with either 1 microM staurosporine or 0.1 microM nigericin, a ladder pattern of DNA fragmentation was induced. As expected, over-expression of Bax in MN9D cells accelerated staurosporine-induced cell death as measured by the MTT reduction assay (62.3% survival in MN9D/Neo vs 27.0% survival in MN9D/Bax). Surprizingly, both nigericin-induced cell death and its accompanying DNA fragmentation were largely attenuated in MN9D/Bax cells (22.0% survival in MN9D/Neo vs 86.7% survival in MN9D/Bax). Similar patterns were observed in two other MN9D/Bax cell lines. Cleavage of poly(ADP-ribose)polymerase caused by nigericin was greatly attenuated in MN9D/Bax cells suggesting that, like Bcl-2, Bax suppresses nigericin-induced cell death by inhibiting the activation of cysteine proteases. Thus, our data imply that Bax acts as a negative or positive regulator of cell death depending on the type of death stimulus applied to the cell.
Os romances para a juventude de António Mota (2014)

Neste ensaio, pretende-se estudar os temas e o estilo dos romances para a infância e a juventude de Antonio Mota. Nos livros do autor de Pedro Alecrim , a vida aparece como um permanente e plural desafio, a que cada personagem, a partir da sua individualidade e liberdade, responde enquanto actor que se move num complexo quadro familiar e cultural. A dualidade e a tensao interna das personagens atravessam in- variavelmente as narrativas, mas impoe-se sempre uma visao apoteotica da vida. O enunciador, gerindo e respeitando as vozes que dizem a proposicao irrefutavel de que a vida e dificil e injusta, contrapoe as suas proprias duvidas e medos uma especie de utopia: a vida so vale a pena se for a constante invencao de um ideal. A uma desistencia ou a um abatimento seguem-se uma reaccao, um movimento de energia e uma (re)construcao.
Pupillary dilation response reflects surprising moments in music (2018)

There are indications that the pupillary dilation response (PDR) reflects surprising moments in an auditory sequence such as the appearance of a deviant noise against repetitively presented pure tones (4), and salient and loud sounds that are evaluated by human paricipants subjectively (12). In the current study, we further examined whether the reflection of PDR in auditory surprise can be accumulated and revealed in complex and yet structured auditory stimuli, i.e., music, and when the surprise is defined subjectively. Participants listened to 15 excerpts of music while their pupillary responses were recorded. In the surprise-rating session, participants rated how surprising an instance in the excerpt was, i.e., rich in variation versus monotonous, while they listened to it. In the passive-listening session, they listened to the same 15 excerpts again but were not involved in any task. The pupil diameter data obtained from both sessions were time-aligned to the rating data obtained from the surprise-rating session. Results showed that in both sessions, mean pupil diameter was larger at moments rated more surprising than unsurprising. The result suggests that the PDR reflects surprise in music automatically.
Heteroepitaxy of Cd-Rich CaxCd1-xF2Alloy on Si Substrates and Its Application to Resonant Tunneling Diodes (2003)

Epitaxial growth of Cd-rich CaxCd1-xF2 alloy with small composition x on Si(111) substrates was investigated in order to obtain improved fluoride resonant tunneling diodes (RTDs). The direct growth of CdF2 on Si substrates was studied from the viewpoint of surface roughening and sticking coefficient, and it was revealed that the origin of growth instability of CdF2 was the direct reactivity of CdF2 with Si. This phenomenon was controlled by addition of a small amount of CaF2 to CdF2, forming a Cd-rich CaxCd1-xF2 alloy. It was found that the growth temperature of Cd-rich CaxCd1-xF2 on bare Si at which apparent re-evaporation was observed was higher than that of pure CdF2, and that the surface roughness of the layers grown at room temperature on thin CaF2 buffer layers was reduced by the addition of only 5% CaF2 to CdF2. Furthermore, RTDs using the Cd-rich CaxCd1-xF2 layer for the quantum well layer were fabricated, and stable operation and improved characteristics were obtained compared to the conventional RTDs using pure CdF2 layers.
Cyber-Physical Systems of Microgrids for Electrical Grid Resiliency (2019)

Microgrids are increasingly being adopted in distribution systems to maintain operation of electrical systems in adverse situations, such as storms or cyber attacks. Modern microgrids rely on cyber communication for fast measurement and control of intelligent distributed energy resources (DERs), making microgrids complex cyber-physical systems. This work presents control strategies, as well as approaches for resiliency to attacks against measurements, system stability, and secure communications within and between partitions when microgrids are islanded from the utility area electric power system. Modes of graceful degradation, whose objective is to continuously serve identified critical loads, are presented. Finally, we conclude with a use case that unifies all concepts, in which we mitigate effects of an attack against generation on a critical load bus. Mitigation is achieved by consensus between controllers for peer systems to close a normally open tie line between two systems. The attack is detected, the suspicious DER is tripped, and the appropriate tie line between the two systems is closed to continuously supply the critical load. Rapid, secure communication of measurements between the systems allows the stability algorithm to restore stability of the now-combined system within an acceptable time interval. Results from real-time simulation are provided to validate the effectiveness of our approach.
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study (2022)

Action for Pulmonary Fibrosis, Medical Research Council, Wellcome Trust, and National Institutes of Health National Heart, Lung, and Blood Institute.
A nucleophilic acetaldehyde equivalent. Preparation and synthetic applications of cis-2-ethoxyvinyllithium (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA nucleophilic acetaldehyde equivalent. Preparation and synthetic applications of cis-2-ethoxyvinyllithiumRobert H. Wollenberg, Kim F. Albizati, and Rohan PeriesCite this: J. Am. Chem. Soc. 1977, 99, 22, 7365–7367Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/ja00464a051https://doi.org/10.1021/ja00464a051research-articleACS PublicationsRequest reuse permissionsArticle Views864Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pretargeted 177Lu Radioimmunotherapy of Carcinoembryonic Antigen–Expressing Human Colonic Tumors in Mice (2010)

This study indicates that PRIT in mice is an effective treatment modality against colon cancer, with limited toxicity.
Light confinement-induced antireflection of ZnO nanocones (2011)

The antireflective features of aperiodic vertical aligned ZnO nanocones on Si wafer were studied both experimentally and theoretically through comparison with planar ZnO films on Si substrates and bare Si substrates. The measured diffuse reflectance spectra show that the nanocone-based texture reduces the light reflection in a broad spectral range and is much more effective than the planar textures. The numerical simulations exhibit a good agreement with the experimental data and suggest that the light confinement inside nanocones by controlling the diameters can bring further improvement of light absorption into Si.
Superoxide radical production by sponges Sycon sp (1998)

Using the catechol Tiron as an O2-. scavenger, we showed that sea sponges (Sycon sp.) produce superoxide radicals in sea water at a high rate without any stimuli added. The rate of O2-. outflow from sponges to their water surroundings reaches a value of 0.5 nmol/min per sponge at pH 6.5. The generation of O2-. was inhibited by Cu,Zn-superoxide dismutase, and restored by the addition of KCN. We also confirmed the abiotic production of O2-. in sea water, detected earlier with a different method by Petasne and Zika [Nature 325 (1987) 516-518].