gebhart/patrepeval huggingface dataset:
Electrical conductivity of metastable κ-CeZrO4 phase possessing ordered arrangement of Ce and Zr ions (2001)

Electrical conductivity σt of metastable κ-CeZrO4 possessing ordered arrangement of Ce and Zr ions in a manner similar to a pyrochlore-type was measured as a function of temperature and time, and compared with tetragonal metastable t′-(Ce0.5Zr0.5)O2 and t′meta-(Ce0.5Zr0.5)O2 phases possessing random arrangement of the cations. The κ disk was prepared by reoxidizing a pyrochlore-type precursor in O2 gas at 873 K. The σt as measured for the κ-CeZrO4 was reproducible as a function of temperatures between 957 and 1190 K. At increasing temperatures above 1233 K, the σt decreased gradually with time due to the phase transition: κ → t′, and became consistent with the t′. Although the κ-CeZrO4 phase is thermodynamically less stable than the t′-(Ce0.5Zr0.5)O2, it was virtually stable up to around 1233 K. It was found from the change in the σt due to the phase transition that the σt(Ce0.5Zr0.5)O2 for the metastable κ-CeZrO4 was an order of magnitude higher than that for the t′ and was similar to that for the σtmeta. It was previously reported that a phase transition, t′ → t′, occurred above 1143 K. The phase transition, κ → t′, accompanied by redistribution of the cations appeared to occur at higher temperatures than that for t′meta → t′ leaving random cation arrangement.
Reseña de: Osgood, Josiah, <em>Roma: La creación del estado mundo</em> (2019)

Reseña de: Osgood, Josiah, Roma: La creación del estado mundo, Madrid, Desperta Ferro Ediciones, 2019, 365 pp., ISBN: 978-84-949540-1-6.
ChemInform Abstract: N‐Diethylgermyl Derivatives of Methyl 3‐Amino‐2‐thiophenoate. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue (2015)

Mesenchymal stromal/stem cells (MSCs) demonstrate immunomodulation capacity that has been implicated in the reduction of graft-versus-host disease. Accordingly, we herein investigated the capacity of MSCs derived from several tissue sources to modulate both proinflammatory (interferon [IFN] γ and tumor necrosis factor [TNF] α) and immunosuppressive cytokines (transforming growth factor [TGF] β and interleukin [IL] 10) employing xenogeneic human MSC-mixed lymphocyte reaction (MLR) test. Bone marrow-derived MSCs showed higher self-renewal capacity with relatively slow proliferation rate in contrast to adipose-derived MSCs which displayed higher proliferation rate. Except for the lipoprotein gene, there were no marked changes in osteogenesis- and adipogenesis-related genes following in vitro differentiation; however, the histological marker analysis revealed that adipose MSCs could be differentiated into both adipose and bone tissue. TGFβ and IL10 were detected in adipose MSCs and bone marrow MSCs, respectively. However, skin-derived MSCs expressed both IFNγ and IL10, which may render them sensitive to immunomodulation. The xenogeneic human MLR test revealed that MSCs had a partial immunomodulation capacity, as proliferation of activated and resting peripheral blood mononuclear cells was not affected, but this did not differ among MSC sources. MSCs were not tumorigenic when introduced into immunodeficient mice. We concluded that the characteristics of MSCs are tissue source-dependent and their in vivo application requires more in-depth investigation regarding their precise immunomodulation capacities.
Computational Pathology: A Path Ahead (2015)

The meeting made recommendations to promote computational pathology, including clearly defining the field and articulating its value propositions; asserting that the value propositions for health care systems must include means to incorporate robust computational approaches to implement data-driven methods that aid in guiding individual and population health care; leveraging computational pathology as a center for data interpretation in modern health care systems; stating that realizing the value proposition will require working with institutional administrations, other departments, and pathology colleagues; declaring that a robust pipeline should be fostered that trains and develops future computational pathologists, for those with both pathology and nonpathology backgrounds; and deciding that computational pathology should serve as a hub for data-related research in health care systems. The dissemination of these recommendations to pathology and bioinformatics departments should help facilitate the development of computational pathology.
Overview of the Blue Gene/L system (2005)

The Blue Genet/L computer is a massively parallel supercomputer based on IBM system-on-a-chip technology. It is designed to scale to 65,536 dual-processor nodes, with a peak performance of 360 teraflops. This paper describes the project objectives and provides an overview of the system architecture that resulted. We discuss our application-based approach and rationale for a low-power, highly integrated design. The key architectural features of Blue Gene/L are introduced in this paper: the link chip component and five Blue Gene/L networks, the PowerPCt 440 core and floatingpoint enhancements, the on-chip and off-chip distributed memory system, the node- and system-level design for high reliability, and the comprehensive approach to fault isolation.
Three Statistical Approaches to Sessionizing Network Flow Data (2014)

The network traffic generated by a computer, or a pair of computers, is often well modelled as a series of sessions. These are, roughly speaking, intervals of time during which a computer is engaging in the same, continued, activity. This article explores a variety of statistical approaches to re-discovering sessions from network flow data using timing alone. Solutions to this problem are essential for network monitoring and cyber-security. For example overlapping sessions on a computer network can be evidence of an intruder 'tunnelling'.
Neutrophil migration assay from a drop of blood (2008)

Neutrophil directional migration in response to chemical gradients, also known as chemotaxis, is one of the key phenomena in the immune responses against bacterial infection. To better study neutrophils chemotaxis, several in vitro assays have been developed that replicate chemotactic gradients around neutrophils isolated from whole blood. One drawback for most of these assays is the lengthy processing of blood required for neutrophils isolation, which can alter the responsiveness of neutrophils compared to the in vivo conditions. To address this limitation, we have designed a microfluidic chip for chemotaxis studies which can use neutrophils isolated on the chip, directly from whole blood. We have tested three different cell adhesion molecules as substrates for neutrophil isolation (P-selectin, E-selectin and fibronectin) and found average capture efficiencies of 20-40 neutrophils/mm2 at optimized concentrations. Subsequent analysis of neutrophil migration in chemoattractant gradients of N-formyl-methyl-leucyl-phenylalanine (fMLP) or Interleukin-8 (IL-8) shows higher average velocities over E-selectin as compared to the P-selectin. Our microfluidic assay uses just a drop of whole blood (<10 microL) for neutrophil isolation and provides a robust platform to perform chemotaxis assays in the competing environment of different chemokines.
Vδ2-Jα rearrangements are frequent in precursor-B–acute lymphoblastic leukemia but rare in normal lymphoid cells (2003)

The frequently occurring T-cell receptor delta (TCRD) deletions in precursor-B-acute lymphoblastic leukemia (precursor-B-ALL) are assumed to be mainly caused by Vdelta2-Jalpha rearrangements. We designed a multiplex polymerase chain reaction tified clonal Vdelta2-Jalpha rearrangements in 141 of 339 (41%) childhood and 8 of 22 (36%) adult precursor-B-ALL. A significant proportion (44%) of Vdelta2-Jalpha rearrangements in childhood precursor-B-ALL were oligoclonal. Sequence analysis showed preferential usage of the Jalpha29 gene segment in 54% of rearrangements. The remaining Vdelta2-Jalpha rearrangements used 26 other Jalpha segments, which included 2 additional clusters, one involving the most upstream Jalpha segments (ie, Jalpha48 to Jalpha61; 23%) and the second cluster located around the Jalpha9 gene segment (7%). Real-time quantitative PCR studies of normal lymphoid cells showed that Vdelta2 rearrangements to upstream Jalpha segments occurred at low levels in the thymus (10(-2) to 10(-3)) and were rare (generally below 10(-3)) in B-cell precursors and mature T cells. Vdelta2-Jalpha29 rearrangements were virtually absent in normal lymphoid cells. The monoclonal Vdelta2-Jalpha rearrangements in precursor-B-ALL may serve as patient-specific targets for detection of minimal residual disease, because they show high sensitivity (10(-4) or less in most cases) and good stability (88% of rearrangements preserved at relapse).
[Cartilage/chondrocyte research and osteoarthritis. Regeneration of articular cartilage damage using iPS cell-derived cartilage.] (2019)

Induced pluripotent stem (iPS)cells have capacities of self-renewal and pluripotency. We have developed a method to differentiate human iPS cells toward chondrocytes, followed by the creation of cartilage tissue composed of chondrocytes and cartilage extracellular matrix. The mechanism through which tissue transplantation repairs cartilage defects involves the transplant itself constituting the repair tissue. Human iPS cell-derived cartilage has low immunogenicity and can be transplanted in an allogeneic manner. We are conducting pre-clinical tests on iPS cell-derived cartilage to verify efficacy and safety that will act as a basis for clinical tests.
Minimality, stabilizability, and strong stabilizability of uncertain plants (1993)

This paper considers a set of uncertain transfer functions whose numerator and denominators belong to independent polytopes. It shows that i) the members of this set are free from pole-zero cancellations iff all the ratios of numerator edges and denominator edges are free from pole-zero cancellations and the numerator and denominator corners evaluated at a finite number of points satisfy certain phase conditions, ii) the members of this set are free from pole zero cancellations in the closed right half plane, iff all the ratios of numerator edges and denominator edges are free from pole-zero cancellations in the closed right half plane, and the numerator and denominator corners evaluated at a finite number of points satisfy certain phase conditions, and iii) in the strictly proper case, all plants in the set are strongly stabilizable iff all plants avoid pole-zero cancellations in the closed right half plane and all the corner ratios are strongly stabilizable. A counter-example is presented to show that this last result does not extend to biproper plants.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Scheduling Study in HSDPA System (2006)

This paper focuses on the study of scheduling techniques in HSDPA system. In this context, we propose to use the score based (SB) scheduling algorithm in HSDPA. This algorithm is compared to another scheduling algorithm, called proportional fair (PF), widely used and studied in the literature. To make this comparison, an analytical model allowing to evaluate the cell capacity and the user bit rate is proposed. The radio channel is assumed to he a dense multipath frequency selective channel with uncorrelated signal envelope following a Rayleigh distribution and wide-sense stationary uncorrelated scattering (WSSUS). Results show that SB seems to be a better trade-off between "fairness" and "efficiency" than PF
The FMS Search Kernel and its Performance Characteristics (2007)

This thesis focuses on methods and analysis for building scalable Internet Search Engines. In this work, we have developed a search kernel, an architecture framework and applications that are being used in industrial and commercial products. Furthermore, we present both analysis and design of key elements. Essential to building a large-scale search engine is to understand the dynamics of the content in which we are searching. For the challenging case of searching the web, there are multiple dimensions of dynamics that should ideally be handled. In this thesis we start by examining some of these dimensions and the implications they have on search engine design.When designing a search engine kernel, the focus has been on selection of algorithms and datastructures in the general case. Also, and even more important, we design worst-case characteristics into the search kernel that are very decisive from a scaling standpoint. A performance model to analyze the behaviour of the kernel is also developed. The designed search engine kernel was realized as a predecessor of the current FAST Search kernel (the FMS kernel), and practical experiments and benchmarking demonstrate the correctness of the assumptions from the design of the kernel. Then a framework for scaling shared-nothing systems based upon nodes working on separate portions of the data is introduced. The design of the framework is based on the general principles of replication and distribution. A performance model and an algorithm for cluster design are provided. This is in turn applied to construct a larger-scale web search engine and benchmarking of clusters indicate that the assumptions and models for the distributed architecture hold. The scaling aspect of search engine is further studied in the context of the application itself. Query locality is explored and used to create an architecture that is a generalized type of caching (through partial replication) using the application behaviour and a configurable correctness trade-off to design super-linear scalable search engines.Finally, a discussion of how linguistics are being used in web search engines is provided, focusing on the constraints that apply to ensure the desired scalability.
Data Sanitization Approach to Mitigate Clean-Label Attacks Against Malware Detection Systems (2022)

Machine learning (ML) models are increasingly being used in the development of Malware Detection Systems. Existing research in this area primarily focuses on developing new architectures and feature representation techniques to improve the accuracy of the model. However, recent studies have shown that existing state-of-the art techniques are vulnerable to adversarial machine learning (AML) attacks. Among those, data poisoning attacks have been identified as a top concern for ML practitioners. A recent study on clean-label poisoning attacks in which an adversary intentionally crafts training samples in order for the model to learn a backdoor watermark was shown to degrade the performance of state-of-the-art classifiers. Defenses against such poisoning attacks have been largely under-explored. We investigate a recently proposed clean-label poisoning attack and leverage an ensemble-based Nested Training technique to remove most of the poisoned samples from a poisoned training dataset. Our technique leverages the relatively large sensitivity of poisoned samples to feature noise that disproportionately affects the accuracy of a backdoored model. In particular, we show that for two state-of-the art architectures trained on the EMBER dataset affected by the clean-label attack, the Nested Training approach improves the accuracy of backdoor malware samples from 3.42% to 93.2%. We also show that samples produced by the clean-label attack often successfully evade malware classification even when the classifier is not poisoned during training. However, even in such scenarios, our Nested Training technique can mitigate the effect of such clean-label-based evasion attacks by recovering the model's accuracy of malware detection from 3.57% to 93.2%.
Drosophila as a model for the identification of genes causing adult human heart disease (2006)

Drosophila melanogaster genetics provides the advantage of molecularly defined P-element insertions and deletions that span the entire genome. Although Drosophila has been extensively used as a model system to study heart development, it has not been used to dissect the genetics of adult human heart disease because of an inability to phenotype the adult fly heart in vivo. Here we report the development of a strategy to measure cardiac function in awake adult Drosophila that opens the field of Drosophila genetics to the study of human dilated cardiomyopathies. Through the application of optical coherence tomography, we accurately distinguish between normal and abnormal cardiac function based on measurements of internal cardiac chamber dimensions in vivo. Normal Drosophila have a fractional shortening of 87 +/- 4%, whereas cardiomyopathic flies that contain a mutation in troponin I or tropomyosin show severe impairment of systolic function. To determine whether the fly can be used as a model system to recapitulate human dilated cardiomyopathy, we generated transgenic Drosophila with inducible cardiac expression of a mutant of human delta-sarcoglycan (deltasg(S151A)), which has previously been associated with familial dilated cardiomyopathy. Compared to transgenic flies overexpressing wild-type deltasg, or the standard laboratory strain w(1118), Drosophila expressing deltasg(S151A) developed marked impairment of systolic function and significantly enlarged cardiac chambers. These data illustrate the utility of Drosophila as a model system to study dilated cardiomyopathy and the applicability of the vast genetic resources available in Drosophila to systematically study the genetic mechanisms responsible for human cardiac disease.
Exact correction of image distortion in a filter wheel multispectral camera with focus adjustment (2018)

Abstract The correction of inter-channel image distortions in multispectral imaging is the key process for high-precision applications. In this work, image distortion in a special filter wheel camera with sensor actuation based focus adjustment is investigated. Based on the analysis of the optical path, error compensation models at different levels are derived and qualitatively compared with each other. The experimental evaluation of the models shows that the proposed extended radial-tangential model achieves the highest image registration accuracy, especially in the marginal image areas. Furthermore, the stability of these algorithms is evaluated with repeated measurements.
Biological Systems from an Engineer's Point of View (2009)

The robust design of complex systems, such as cruise control, requires a careful balance of several objectives. As biological systems are no different, an engineering approach to these systems proves useful.
Abstract 398: Growth Hormone Releasing Hormone Agonist (GHRH-A) Restores Cardiac Function in a Rodent Model of Heart FailureWith Preserved Ejection Fraction (HFpEF) (2017)

Background: Roughly half of patients with heart failure (HF) have preserved EF (HFpEF) and this rate is increasing. The pathophysiology of HFpEF is unclear and treatment of HFpEF remains a critical unmet need. Hypothesis: Growth hormone releasing hormone agonist (GHRH-A) restores cardiac function in a rodent model of HFpEF. Methods: C57BL/6N mice (n=4-5) received angiotensin-II (Ang-II: 0.8 mg/kg/day) via mini-osmotic pump for 4 weeks with concurrent daily administration of GHRH-A (MR-356: 200 μg/kg) or vehicle (DMSO+propylene-glycol). Echocardiography was assessed at baseline and 4 weeks after Alzet pump placement. Hemodynamic studies were performed and the titin N2BA/N2B ratio measured. Results: Ang-II administration increased end-diastolic pressure (EDP, p=0.0186) with no changes in EF (p=ns) or end-systolic pressure (ESP, p=ns) in comparison to control mice. Isovolumetric relaxation time (IVRT, p&lt;0.05) and end-diastolic pressure-volume relationship (EDPVR, p=0.0229) were significantly increased in the Ang-II/vehicle group, consistent with increased ventricular stiffness and impaired relaxation. Importantly, GHRH-A treatment reset these parameters to normal conditions (table). HFpEF mice exhibited higher HW/BW ratios and lung weight. The titin N2BA/N2B ratio, which was increased (p&lt;0.05) in the Ang-II group, was restored by GHRH-A treatment. Conclusion: Chronic administration of Ang-II mediates structural and functional changes that mimic HFpEF. GHRH-A treatment improves diastolic dysfunction and impaired relaxation. Therefore, GHRH-A therapy may be beneficial in the treatment of HFpEF.
Modeling and Control of Steering System of Heavy Vehicles for Automated Highway Systems (2004)

This work presents modeling, analysis, and controller design of the steering subsystem of heavy vehicles as a subsystem of vehicle lateral control system for the automated highway systems. A physical model of the steering subsystem is derived where the hydraulic power assist unit is modeled as a family of static nonlinear boost curves. Based on open-loop frequency tests and analysis of the physical model structure and its dynamical characteristics, a nominal second order linear model of the steering subsystem is obtained. Then, a linear robust loop-shaping controller is designed to provide a good tracking performance of the closed-loop dynamics of the steering subsystem for varying gain cross over frequencies which is a result of the nonlinear characteristics of the hydraulic power assist. The controller has been successfully incorporated as an inner-loop controller into the nested lateral control architecture for autonomous driving and its efficacy has been demonstrated experimentally.
A 65 nm CMOS technology for mobile and digital signal processing applications (2005)

This paper presents a 65 nm CMOS technology that achieves a logic density of 900 k-gates/mm/sup 2/ and a SRAM memory density of 1.4 Mb/mm/sup 2/ using a sub-0.49 /spl mu/m/sup 2/ bitcell. Key features of a low cost technology option for mobile products (MP) and a high performance technology option (HP) for DSP based applications are described.
Polarization Independent Operation of U-turn Shape Semiconductor Optical Amplifier by Using PLC-based Polarization Diversity Circuit (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Hasegawa, M. Funabashi, K. Maruyama, T. Akutsu, N. Yokouchi, and K. Nara, "Polarization Independent Operation of U-turn Shape Semiconductor Optical Amplifier by Using PLC-based Polarization Diversity Circuit," in 37th European Conference and Exposition on Optical Communications, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper We.10.P1.30. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Leveraged Freedom Chair: a developing country wheelchair (2010)

The purpose of the Leveraged Freedom Chair (LFC) project is to create a mobility aid specifically for developing countries. Conventional western-styled wheelchairs are nearly impossible to propel on the sandy roads and muddy walking paths frequently encountered in the developing world. The LFC has a variable mechanical advantage lever drivetrain that enables its user to travel 10-20% faster on tarmac than a conventional wheelchair, and off road like no other mobility aid available.