gebhart/patrepeval huggingface dataset:
Block Differential Encoding for Rapidly Fading Channels (2004)

Rapidly fading channels provide Doppler-induced diversity, but are also challenging to estimate. To bypass channel estimation, we derive two novel block differential (BD) codecs. Relying on a basis expansion model for time-varying channels, our differential designs are easy to implement, and can achieve the maximum possible Doppler diversity. The first design (BD-I) relies on a time-frequency duality, based on which we convert a time-varying channel into multiple frequency-selective channels, and subsequently into multiple flat-fading channels using orthogonal frequency-division multiplexing. Combined with a group partitioning scheme, BD-I offers flexibility to trade off decoding complexity with performance. Our second block differential design (BD-II) improves the bandwidth efficiency of BD-I at the price of increased complexity at the receiver, which relies on decision-feedback decoding. Simulation results corroborate our theoretical analysis, and compare with competing alternatives.
Metabolism in Escherichia coli (2015)

Although not everyone is mindful of it all cell biologists have two cells of interest: the one they are studying and Escherichia coli– Frederick Neidhardt
Chip level layout and bias considerations for preventing neighboring I/O cell interaction-induced latch-up and inter-power supply latch-up in advanced CMOS technologies (2005)

CMOS latch-up has historically been a problem in bulk CMOS processes through a parasitic pnpn structure formed by parasitic pnp and npn bipolar transistors. In application systems, latch-up is a dominant failure mode that causes either soft failure due to a loss of data logic states or destructive failure of the system. In this paper, the authors focused on cases of I/O VDD to core VDD latch-up and other cross book latch-up; the significance of this work shows that in 0.13 and sub-0.13 mum technologies, CMOS latch-up can occur between different VDD power supplies and between chip sub-functions. This work advances the CMOS technology by addressing chip-level layout, critical bias considerations, as well as and in conjunction with unit I/O cell level latch-up considerations for preventing neighboring I/O-to-I/O cell interaction-induced latch-up. Additionally, emission microscope (EMMI) techniques and latch-up simulation results were shown.
Selective arraying of complex particle patterns (2010)

Procedures requiring precise and accurate positioning of particles and cells have impacted a broad range of research interests including molecular detection, self-assembly and tissue and cell engineering. These fields would be greatly aided by more advanced, yet straightforward, micro-object positioning methods that are precise, scalable, responsive and flexible. We have developed an arrayed, multilayer surface patterned microfluidic device which uses laminar convective flow to actively position particles into any desired, two-dimensional, predesigned pattern. Objects including 10 microm polystyrene particles and Saccharomycodes ludwigii cells are rapidly (approximately 2 s) loaded onto vacuum-actuated holes, allowing us to both generate anisotropic particles and culture S. ludwigii cells. The device was further modified to individually control two sets of holes, adding control of pattern composition. With rapid, precise and adaptable operation, multilayer microfluidic devices should greatly assist in research where precise object placement and proximity is necessary.
First demonstration of 1580 nm-band large scale WDM ring network over dispersion-shifted fiber employing optical add-drop multiplexers (1997)

Large scale 1580 nm-band WDM network over dispersion-shifted fiber employing add-drop multiplexers is demonstrated for the first time. By shifting the signal wavelength region to 1580 nm, the limitation due to four wave mixing can be avoided, which enables us to construct a 1200 km large scale network with the large node spacing of 120 km.
Hypersensitivity Pneumonitis: Diagnostic and Therapeutic Challenges (2021)

Hypersensitivity pneumonitis (HP) is one of the most common interstitial lung diseases (ILD), that presents unique challenges for a confident diagnosis and limited therapeutic options. The disease is triggered by exposure to a wide variety of inciting antigens in susceptible individuals which results in T-cell hyperactivation and bronchioloalveolar inflammation. However, the genetic risk and the pathogenic mechanisms remain incompletely elucidated. Revised diagnostic criteria have recently been proposed, recommending to classify the disease in fibrotic and non-fibrotic HP which has strong therapeutic and outcome consequences. Confident diagnosis depends on the presence of clinical features of ILD, identification of the antigen(s), typical images on high-resolution computed tomography (HRCT), characteristic histopathological features, and lymphocytosis in the bronchoalveolar lavage. However, identifying the source of antigen is usually challenging, and HRCT and histopathology are often heterogeneous and not typical, supporting the notion that diagnosis should include a multidisciplinary assessment. Antigen removal and treating the inflammatory process is crucial in the progression of the disease since chronic persistent inflammation seems to be one of the mechanisms leading to lung fibrotic remodeling. Fibrotic HP has a few therapeutic options but evidence of efficacy is still scanty. Deciphering the molecular pathobiology of HP will contribute to open new therapeutic avenues and will provide vital insights in the search for novel diagnostic and prognostic biomarkers.
Data from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (&lt;i&gt;K&lt;/i&gt;&lt;sub&gt;d&lt;/sub&gt; = 1.7 nmol/L) and proliferation of human tumor cells with GI&lt;sub&gt;50&lt;/sub&gt; values of approximately 2 to 40 nmol/L, inducing G&lt;sub&gt;1&lt;/sub&gt;-G&lt;sub&gt;2&lt;/sub&gt; arrest and apoptosis. Activity is independent of NQO1/DT-diaphorase, maintained in drug-resistant cells and under hypoxic conditions. The molecular signature of HSP90 inhibition, comprising induced HSP72 and depleted client proteins, was readily demonstrable. NVP-AUY922 was glucuronidated less than previously described isoxazoles, yielding higher drug levels in human cancer cells and xenografts. Daily dosing of NVP-AUY922 (50 mg/kg i.p. or i.v.) to athymic mice generated peak tumor levels at least 100-fold above cellular GI&lt;sub&gt;50&lt;/sub&gt;. This produced statistically significant growth inhibition and/or regressions in human tumor xenografts with diverse oncogenic profiles: BT474 breast tumor treated/control, 21%; A2780 ovarian, 11%; U87MG glioblastoma, 7%; PC3 prostate, 37%; and WM266.4 melanoma, 31%. Therapeutic effects were concordant with changes in pharmacodynamic markers, including induction of HSP72 and depletion of ERBB2, CRAF, cyclin-dependent kinase 4, phospho-AKT/total AKT, and hypoxia-inducible factor-1α, determined by Western blot, electrochemiluminescent immunoassay, or immunohistochemistry. NVP-AUY922 also significantly inhibited tumor cell chemotaxis/invasion &lt;i&gt;in vitro&lt;/i&gt;, WM266.4 melanoma lung metastases, and lymphatic metastases from orthotopically implanted PC3LN3 prostate carcinoma. NVP-AUY922 inhibited proliferation, chemomigration, and tubular differentiation of human endothelial cells and antiangiogenic activity was reflected in reduced microvessel density in tumor xenografts. Collectively, the data show that NVP-AUY922 is a potent, novel inhibitor of HSP90, acting via several processes (cytostasis, apoptosis, invasion, and angiogenesis) to inhibit tumor growth and metastasis. NVP-AUY922 has entered phase I clinical trials. [Cancer Res 2008;68(8):2850–60]&lt;/p&gt;&lt;/div&gt;
An ultra‐pure in vitro phase synchrony method employing centrifugal elutriation and viable flow cytometric cell sorting (1984)

We present a method of synchronizing cells in G1-, S-, and G2M-phases employing sequential centrifugal elutriation and viable flow cytometric cell sorting of Hoechst-33342 stained Chinese hamster ovary cells. G1- and S-phase cells can be separated to greater than 99% homogeneity and G2-M to 70% purity. Most of the 30% contamination in the G2-M fraction was due to S-phase cells, whose reproductive integrity could be eliminated through the use of high specific activity 3H-TdR. There were minimal toxic effects or perturbations to growth following the selection procedures. The most significant limitation of this technique appears to be the rate of cell sorting, which, with current equipment, is approximately 3,000 cells per second.
Understanding Biodiesel Fuel Quality and Performances (2003)

The purpose of this paper is to provide the reader with sufficient information to understand Biodiesel fuel quality and the effect various quality parameters have on diesel equipment performance. Biodiesel is produced from vegetable oils, recycled cooking greases and animal fat. The American Society of Testing Material test methods are used as a basis for drawing comparisons between regular diesel fuel and Biodiesel. Failure to control the processes for manufacturing, blending and storage of Biodiesel can lead to performance problems in all types of diesel fueled equipment.
Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A. (1993)

Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.
Optimization of an Integrated SOFC-Fuel Processing System for Aircraft Propulsion (2012)

As fuel cells continue to improve in performance and power densities levels rise, potential applications ensue. System-level performance modeling tools are needed to further the investigation of future applications. One such application is small-scale aircraft propulsion. Both piloted and unmanned fuel cell aircrafts have been successfully demonstrated suggesting the near-term viability of revolutionizing small-scale aviation. Nearly all of the flight demonstrations and modeling efforts are conducted with low temperature fuel cells; however, the solid oxide fuel cell (SOFC) should not be overlooked. Attributing to their durability and popularity in stationary applications, which require continuous operation, SOFCs are attractive options for long endurance flights. This study presents the optimization of an integrated solid oxide fuel cell-fuel processing system model for performance evaluation in aircraft propulsion. System parameters corresponding to maximum steady state thermal efficiencies for various flight phase power levels were obtained through implementation of the particle swarm optimization (PSO) algorithm. Optimal values for fuel utilization, air stoichiometric ratio, air bypass ratio, and burner ratio, a four-dimensional optimization problem, were obtained while constraining the SOFC operating temperature to 650–1000 °C. The PSO swarm size was set to 35 particles, and the number of iterations performed for each case flight power level was set at 40. Results indicate the maximum thermal efficiency of the integrated fuel cell-fuel processing system remains in the range of 44–46% throughout descend, loitering, and cruise conditions. This paper discusses a system-level model of an integrated fuel cell-fuel processing system, and presents a methodology for system optimization through the particle swarm algorithm.
A 4.1 pJ/b 25.6 Gb/s 4-PAM reduced-state sliding-block Viterbi detector in 14 nm CMOS (2016)

The implementation of a digital four-level pulse-amplitude-modulation reduced-state sliding-block Viterbi detector (VD) with two substates and two embedded per-survivor decision-feedback taps operating at one-eighth of the modulation rate is described. Implemented in an experimental chip fabricated in 14nm CMOS, the VD is designed to recover data at 25.6 Gb/s over an emulated time-dispersive channel. The power consumption of the VD together with the test circuitry is 105mW at a supply of 0.7V, achieving an overall energy efficiency of 4.1 pJ/b. At a supply of 0.8V, a data rate of 30.4 Gb/s is achieved with an energy efficiency of 5.3 pJ/b. The VD occupies an area of 0.507×0.717mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Experimental results showing system performance are obtained using a (2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> -1)-bit pseudo-random binary sequence. The impact on the bit error rate of the synchronization length for block initialization is also measured.
Structure of the N-terminal dimerization domain of CEACAM7 (2015)

CEACAM7 is a human cellular adhesion protein that is expressed on the surface of colon and rectum epithelial cells and is downregulated in colorectal cancers. It achieves cell adhesion through dimerization of the N-terminal IgV domain. The crystal structure of the N-terminal dimerization domain of CEACAM has been determined at 1.47 Å resolution. The overall fold of CEACAM7 is similar to those of CEACAM1 and CEACAM5; however, there are differences, the most notable of which is an insertion that causes the C'' strand to buckle, leading to the creation of a hydrogen bond in the dimerization interface. The Kdimerization for CEACAM7 determined by sedimentation equilibrium is tenfold tighter than that measured for CEACAM5. These findings suggest that the dimerization affinities of CEACAMs are modulated via sequence variation in the dimerization surface.
New Rehabilitation Device Increases Patient Ambulation Following Total Knee Replacement (2012)

Introduction The current standard of care for postoperative support during ambulation is a walker and accompanying gait belt. The use of a walker necessitates awkward body positioning, adequate upper body strength, and prohibits natural foot over foot progression during gait. Additionally, use of a gait belt necessitates that the therapist remains immediately beside or behind the patient, limiting the view of the patient9s gait pattern and placing the therapist and patient at risk should the patient fall. The Secure Tracks™ (Fig 1) is a patient support device which runs in an overhead track and supports the patient in the periaxillary region, providing a more natural body position and foot progression while limiting the risk of falls. This prospective randomized study compares the rate of ambulation and other clinical outcomes measures in a population of total knee replacement recipients postoperatively. Methods A total of 31 unilateral total knee recipients were enrolled in this prospective randomized comparison between the standard of care gait training and the Secure Tracks device. IRB approval was obtained from the relevant oversight board. Patients were permitted to weight-bear as tolerated starting the evening of their surgical procedure. Patients were instructed to walk until they felt fatigued or unsafe and were not encouraged or discouraged to stop. The therapists tracked the distance each patient walked during each of their ambulation sessions and also recorded any incidence of falls or other adverse events. A timed up and go test (TUG) and Visual Analogue Scale for pain (VAS) were also administered at the time of consent, at discharge from the hospital, and at the 2 week clinic followup appointment. Results The mean distance walked by each rehabilitation group at all time points can be found In Table 1. On average, Secure Tracks patients walk between 52% and 152% further in each ambulation session. This amounted to a statistically significant increase on the day of surgery (p=0.021) and the second evening postop (p=0.018). The total distance walked while in the hospital was 96% greater in the Secure Tracks group (2,174 ft), compared to the standard rehabilitation group (1,170 ft) p = 0.035. The results of the timed up and go test are contained In Table 2. Patients in the Secure Tracks group experienced significantly less pain during the TUG test at 2 weeks postoperatively (p = 0.049) and showed a trend to complete the task 3 seconds faster (p = 0.11). There was no statistically significant difference between the time required to complete the task, or the pain level experienced during the task, preoperatively or at discharge. Discussion and Conclusion The Secure Tracks proved to be a safe and effective patient support device that significantly increased the distance that patients walked during the postoperative period. The increased ambulation immediately following surgery likely contributed to the increased speed and decreased pain during the timed up and go test two weeks postoperatively.
Spectral Emission Dependence of Tin‐Vacancy Centers in Diamond from Thermal Processing and Chemical Functionalization (2021)

A systematic photoluminescence (PL) investigation of the spectral emission properties of individual optical defects fabricated in diamond upon ion implantation and annealing is reported. Three spectral lines at 620, 631, and 647 nm are identified and attributed to the SnV center due to their occurrence in the PL spectra of the very same single‐photon emitting defects. It is shown that the relative occurrence of the three spectral features can be modified by oxidizing the sample surface following thermal annealing. The relevant emission properties of each class of individual emitters, including the excited state emission lifetime and the emission intensity saturation parameters are reported.
Multifocal enhancing magnetic resonance imaging lesions following cranial irradiation (1995)

Radiation necrosis is a delayed complication of cranial irradiation, typically presenting as a single intracerebral mass that is radiographically indistinguishable from recurrent tumor. We describe 6 patients with a distinct radiographic syndrome of multifocal enhancing lesions on magnetic resonance images, and their variable clinical courses: some fluctuating, some spontaneously resolving, and some demonstrating fulminant progression to frank necrosis.
Phase-transfer catalysis in the Ullman synthesis of substituted triphenylamines (1987)

Synthese par reaction de diphenylamine avec des iodures d'aryle en presence de K 2 CO 3 -18-crown-6 dans le dichloro-1,2 benzene
SIMULTANEOUS EDGE FLIPPING IN TRIANGULATIONS (2003)

We generalize the operation of flipping an edge in a triangulation to that of flipping several edges simultaneously. Our main result is an optimal upper bound on the number of simultaneous flips that are needed to transform a triangulation into another. Our results hold for triangulations of point sets and for polygons.
Automated extraction chromatographic separations of actinides using separation-optimized sequential injection techniques (1999)

A sequential injection (SI) separation system has been developed for automated analytical separations of actinides using an actinide specific extraction chromatographic material (TRU-resin, Eichrom Industries, Inc., USA). On-line liquid scintillation counting was used to observe eluting species during method development, and fraction collection and alpha energy analysis were used for quantification. Several procedures for individual and group actinide elution are demonstrated and discussed, including elution of actinides as a single group; elution as groups based on valence state; selective separation of Pu using on-column redox chemistry; selective separation of Th; and various sequential actinide elution schemes. Eluent solution compositions and reagent chemistries were investigated with regard to elution peak shapes, selectivity, recoveries, carryover, and suitability for rapid automated procedures. The SI separation methods described serve as the basis for an automated actinide separation work station. An automated actinide separation procedure has been applied towards the analysis of Am, Cm, and Pu isotopes in three types of aged nuclear waste samples. Results from automated analytical separations followed by quantification by alpha spectroscopy were in good agreement with results obtained using manual separation techniques.
Insulin increases De Novo Steroidogenesis in prostate cancer cells (2011)

Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissues. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer; however, regression initially seen with ADT gives way to development of incurable castration-resistant prostate cancer (CRPC). Although ADT generates a therapeutic response, it is also associated with a pattern of metabolic alterations consistent with metabolic syndrome including elevated circulating insulin. Because CRPC cells are capable of synthesizing androgens de novo, we hypothesized that insulin may also influence steroidogenesis in CRPC. In this study, we examined this hypothesis by evaluating the effect of insulin on steroid synthesis in prostate cancer cell lines. Treatment with 10 nmol/L insulin increased mRNA and protein expression of steroidogenesis enzymes and upregulated the insulin receptor substrate insulin receptor substrate 2 (IRS-2). Similarly, insulin treatment upregulated intracellular testosterone levels and secreted androgens, with the concentrations of steroids observed similar to the levels reported in prostate cancer patients. With similar potency to dihydrotestosterone, insulin treatment resulted in increased mRNA expression of prostate-specific antigen. CRPC progression also correlated with increased expression of IRS-2 and insulin receptor in vivo. Taken together, our findings support the hypothesis that the elevated insulin levels associated with therapeutic castration may exacerbate progression of prostate cancer to incurable CRPC in part by enhancing steroidogenesis.