gebhart/patrepeval huggingface dataset:
Air-gap gating of MgZnO/ZnO heterostructures (2014)

The adaptation of “air-gap” dielectric based field-effect transistor technology to controlling the MgZnO/ZnO heterointerface confined two-dimensional electron system (2DES) is reported. We find it possible to tune the charge density of the 2DES via a gate electrode spatially separated from the heterostructure surface by a distance of 5 μm. Under static gating, the observation of the quantum Hall effect suggests that the charge carrier density remains homogeneous, with the 2DES in the 3 mm square sample the sole conductor. The availability of this technology enables the exploration of the charge carrier density degree of freedom in the pristine sample limit.
A new class of uniform filter banks based on recursive Nth-band filters (2005)

This paper introduces a new class of uniform digital filter banks based on DFT and recursive Nth-band filters. We consider both even and odd types of channel stacking arrangements. Due to the use of the DFT, the basic filter bank is complex. Real filter banks are obtained by adding the output signals from two symmetrically located complex channels. The filter banks are designed to satisfy the power complementarity and allpass complementarity constraints with high accuracy. Furthermore, nearly alias-free analyzer-synthesizer system can be obtained in the critically sampled case.
Optical limiting in GaAs (1985)

We have used two-photon absorption, self-defocusing, and optically-induced melting in GaAs to limit 1 μm picosecond pulsed radiation. The contribution to the limiting action from each of these mechanisms is discussed and demonstrated. Additionally, we measure a two-photon absorption coefficient of 26 cm/GW, which is in good agreement with the smallest values reported in the literature. A pulse-width study of the nonlinear absorption was conducted to isolate the effects of two-photon-generated free-carrier absorption. Results indicate that, even though the number of free-carriers is sufficient to severely defocus the incident beam, free-carrier absorption does not measurably contribute to the nonlinear absorption.
Hybrid Chemomechanical Promotion of PEDOT Adhesion onto Flexible Microelectrode Arrays for Chronic Neural Stimulation (2020)

Advances in neural prosthetic technologies demand ever increasing novelty in material composition to enhance the mechanical and electrochemical properties of existing microelectrode arrays. Conductive polymers present advantages such as mechanical flexibility, outstanding biocompatibility, remarkable electrical properties and, most of all, cellular agreement. However, for long-term chronic applications, they fall short in their electrochemical endurance and mechanical adhesion to their substrate materials. Multiple electrochemical approaches have been investigated to improve the adherence of Poly(3,4-ethylenedioxythiophene) (PEDOT) to underlying metallic thin films. In this work, an electrochemical treatment of diazonium salt on platinum microelectrodes is incorporated as an electrochemical adhesion promoter for PEDOT and it is further combined with using the highly microporous geometry of Platinum Grey (Pt-Grey); a technology developed by Second Sight Medical Products Inc (SSMP). The intertwined mechanical integration of Pt-Grey and PEDOT molecules together with the covalent binding agency of diazonium salt demostrate a composite coating technology with long-term stability of more than 452 days while providing &gt;70× enhancement to the interfacial capacitive impedance.
Immunoaffinity Chromatography: A Review (2012)

Affinity chromatography is a high resolution, high capacity, and one of the most powerful and diverse methods for separating proteins and other biological molecules of interest on the basis of a highly specific, reversible biological interaction between two molecules: an affinity ligand attached to a solid matrix to create a stationary phase, and a target molecule in a mobile phase. Specifically, immunoaffinity chromatography (IAC) relies on a solid stationary phase consisting of an antibody coupled to a chromatographic matrix or to magnetic beads, and harnesses the selective and strong binding of antibodies to their targets (Hage, 1998). Accordingly, any molecule that can be bound effectively by an antibody can be purified using IAC (Lesney, 2003). Purified antibodies are coupled to the inert solid phase and mixed with the antigen solution under conditions that favor adsorption. Following antigen capture, unwanted antigens are removed by washing, and the purified antigen is released by switching to conditions that favor desorption. Purification (often greater than 1000-fold) and simultaneous concentration of the target protein are thus achieved (Fitzgerald et al., 2011). One of the first uses of IAC was reported in 1951 by Campbell et al. who used immobilized bovine serum albumin on p-aminobenzyl cellulose to purify antialbumin antibodies. Since then, there has been a great expansion in the applications of IAC for analytical, clinical, and diagnostic purposes.
P4‐062: Mild cognitve impairment: A fluctuating cognitve state (2009)

Almost all studies of Mild Cognitive Impairment (MCI) have used baseline and one follow-up measurement to determine the clinical course of MCI. This study utilizes serial evaluations over a 60 month period to make a more 'microscopic' evaluation of change than previously reported. Elderly controls and participants for this study came from a large study on relating brain iron metabolism to AD pathogenesis. One result of the methodology of this study was that participants were evaluated approximately every six months, which allowed a more fine-tuned neurocognitive picture to be drawn rather than re-testing once post-baseline. A community-based cohort of 112 normal and 83 MCI volunteers were followed zero to 60 months, with 70 having more than one measurement. Neuropsychological tests measuring episodic memory, set shifting, word fluency, confrontational naming and executive functioning and the informant-based measure of daily life functioning were used to determine baseline functioning and for the follow-up. Of the 28 participants classified as neurocognitively normal, 26 remained normal and two progressed to MCI. We found that of the 70 participants entering the study as MCI, 10 became normal, 32 remained MCI and 28 progressed to dementia, which is consistent with previously reported conversion rates. The 10 baseline MCI which were subsequently re-classified to normal on post hoc analysis, exhibited normal scores on at least 3(minimum 3, maximum 10) of their last neuropsychological evaluations. Neurocognitive normals (NCN) experienced a robust practice effect on episodic memory and lack of preservative errors, which was not seen in the MCI group, who failed to benefit from practice effects. Without multiple measures, a 1 in 7 MCI could be misclassified as stable MCI when they have reverted to normal, depending on when a single follow-up was done, resulting in a possible misdiagnosis. One of the distinctions between NCN and MCI is the failure of the latter to benefit from practice effects over 60 months, suggesting something in the nature of the disorder forestalls them even with continuous exposure to the stimulus. This research was funded by NIH Grant #AG20948.
Supplementary Table S4 from Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors (2023)

Supplementary Table S4 from Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors
Evidence of minimal methanogenic numbers and activity in sediments collected from the JAPEX/JNOC/GSC et al. Mallik 5L-38 gas hydrate research well (2005)

Twenty-three cores from JAPEX/JNOC/GSC et al. Mallik 5L-38 gas hydrate research well were characterized to determine if methanogens were present. Archaeal 16S rDNA could be detected in only six of the samples resulting in eight sequences with relationship to the Miscellaneous Crenarchaeotic Group (seven clones) and the Subsurface Euryarchaeotic Group (one clone). The single Euryarchaeota sequence appeared to be unrelated to methanogens. Subsamples from the same cores yielded variable results upon DNA extraction and amplification. Although methanogenic CoenzymeM(CoM) was detected in 13 of the 20 cores tested, methanogenic methyl CoM reductase (mcr) genes were not amplified from the samples when using a sensitive quantitative polymerase chain reaction technique. No methane was generated in cultures amended with radiolabelled substrates. Variable detection of archaeal DNA suggests that it exists in low quantities or that microbial presence in the sediments is dictated on a small scale. Overall, the data suggest exceedingly low methanogen numbers and activities in these deep sediments.
La Mejora de la Regulacion de los Centros Sanitarios (1994)

Journal Article Lá Mejora de la Regulación de los Centros Sanitarios Get access R. FLEISHMAN, R. FLEISHMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar G. MIZRACHI, G. MIZRACHI Search for other works by this author on: Oxford Academic PubMed Google Scholar A. DYNIA, A. DYNIA Search for other works by this author on: Oxford Academic PubMed Google Scholar D. WALT, D. WALT Search for other works by this author on: Oxford Academic PubMed Google Scholar V. SHIRAZI y A. SHAPIRA V. SHIRAZI y A. SHAPIRA Search for other works by this author on: Oxford Academic PubMed Google Scholar International Journal for Quality in Health Care, Volume 6, Issue 1, March 1994, Page 111, https://doi.org/10.1093/intqhc/6.1.111 Published: 01 March 1994
Multispectral imaging for highly accurate analysis of tumour‐infiltrating lymphocytes in primary melanoma (2016)

Our study highlights the potential of MSI for accurate assessment of immune cell infiltrates, including those in notoriously difficult tissues, such as pigmented melanomas. Quantification of tumour infiltration by different immune cell types is crucial in the search for new biomarkers to predict patient responses to immunotherapies. Our findings show that this innovative microscopy technique is an important extension of the armamentarium of pathologists.
NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus (2015)

The GluN2D subunit of the NMDA receptor is prominently expressed in the basal ganglia and associated brainstem nuclei, including the subthalamic nucleus (STN), globus pallidus, striatum, and substantia nigra. However, little is known about how GluN2D-containing NMDA receptors contribute to synaptic activity in these regions. Using Western blotting of STN tissue punches, we demonstrated that GluN2D is expressed in the rat STN throughout development [age postnatal day 7 (P7)-P60] and in the adult (age P120). Immunoelectron microscopy of the adult rat brain showed that GluN2D is predominantly expressed in dendrites, unmyelinated axons, and axon terminals within the STN. Using subunit-selective allosteric modulators of NMDA receptors (TCN-201, ifenprodil, CIQ, and DQP-1105), we provide evidence that receptors containing the GluN2B and GluN2D subunits mediate responses to exogenously applied NMDA and glycine, as well as synaptic NMDA receptor activation in the STN of rat brain slices. EPSCs in the STN were mediated primarily by AMPA and NMDA receptors and GluN2D-containing NMDA receptors controlled the slow deactivation time course of EPSCs in the STN. In vivo recordings from the STN of anesthetized adult rats demonstrated that the spike firing rate was increased by the GluN2C/D potentiator CIQ and decreased by the GluN2C/D antagonist DQP-1105, suggesting that NMDA receptor activity can influence STN output. These data indicate that the GluN2B and GluN2D NMDA receptor subunits contribute to synaptic activity in the STN and may represent potential therapeutic targets for modulating subthalamic neuron activity in neurological disorders such as Parkinson's disease.
A robotic platform for fluidically-linked human body-on-chips experimentation (2019)

Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and an integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection, and in situ microscopic imaging of up to 10 Organ Chips inside a standard tissue culture incubator. The automated Interrogator platform maintained the viability and organ-specific functions of 8 different vascularized, 2-channel, Organ Chips (intestine, liver, kidney, heart, lung, skin, blood-brain barrier (BBB), and brain) for 3 weeks in culture when fluidically coupled through their endothelium-lined vascular channels using a common blood substitute medium. When an inulin tracer was perfused through the multi-organ Human Body-on-Chips (HuBoC) fluidic network, quantitative distributions of this tracer could be accurately predicted using a physiologically-based multi-compartmental reduced order (MCRO) in silico model of the experimental system derived from first principles. This automated culture platform enables non-invasive imaging of cells within human Organ Chips and repeated sampling of both the vascular and interstitial compartments without compromising fluidic coupling, which should facilitate future HuBoc studies and pharmacokinetics (PK) analysis in vitr o.
Characterizing the role of the structural connectome in seizure dynamics (2019)

How does the human brain's structural scaffold give rise to its intricate functional dynamics? This is a central question in translational neuroscience that is particularly relevant to epilepsy, a disorder affecting over 50 million subjects worldwide. Treatment for medication-resistant focal epilepsy is often structural-through surgery or laser ablation-but structural targets, particularly in patients without clear lesions, are largely based on functional mapping via intracranial EEG. Unfortunately, the relationship between structural and functional connectivity in the seizing brain is poorly understood. In this study, we quantify structure-function coupling, specifically between white matter connections and intracranial EEG, across pre-ictal and ictal periods in 45 seizures from nine patients with unilateral drug-resistant focal epilepsy. We use high angular resolution diffusion imaging (HARDI) tractography to construct structural connectivity networks and correlate these networks with time-varying broadband and frequency-specific functional networks derived from coregistered intracranial EEG. Across all frequency bands, we find significant increases in structure-function coupling from pre-ictal to ictal periods. We demonstrate that short-range structural connections are primarily responsible for this increase in coupling. Finally, we find that spatiotemporal patterns of structure-function coupling are highly stereotyped for each patient. These results suggest that seizures harness the underlying structural connectome as they propagate. Mapping the relationship between structural and functional connectivity in epilepsy may inform new therapies to halt seizure spread, and pave the way for targeted patient-specific interventions.
Evaluation of BIC and Cross Validation for model selection on sequence segmentations (2010)

Segmentation is a general data mining technique for summarising and analysing sequential data. Segmentation can be applied, e.g., when studying large-scale genomic structures such as isochores. Choosing the number of segments remains a challenging question. We present extensive experimental studies on model selection techniques, Bayesian Information Criterion (BIC) and Cross Validation (CV). We successfully identify segments with different means or variances, and demonstrate the effect of linear trends and outliers, frequently occurring in real data. Results are given for real DNA sequences with respect to changes in their codon, G + C, and bigram frequencies, and copy-number variation from CGH data.
ChemInform Abstract: Combinatorial Libraries of Transition Metal Complexes, Catalysts and Materials (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lymph Node Staging by Positron Emission Tomography in Cervical Cancer: Relationship to Prognosis (2010)

PURPOSE A previous retrospective study demonstrated that positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) was more sensitive than computed tomography for lymph node staging in patients with cervical cancer; the findings on FDG-PET were strongly associated with progression-free survival. Therefore, a prospective cohort study was initiated to evaluate FDG-PET lymph node staging in a larger patient population. PATIENTS AND METHODS The study was conducted between July 2000 and March 2009. All 560 patients with cervical cancer underwent pretreatment FDG-PET lymph node staging. Treatment included surgery alone, surgery and postoperative radiation therapy, and definitive radiation or combination radiation and chemotherapy. PET findings were correlated with the risk of disease progression and with survival. Results Overall, 47% of patients had lymph node involvement by FDG-PET at diagnosis. The frequency of lymph node metastasis increased with clinical stage and was similar to that in historical surgical series. Within a stage, patients with PET-positive lymph nodes had significantly worse disease-specific survival than those with PET-negative lymph nodes (P < .001). Disease-specific survival was stratified into distinct groups based on the most distant level of PET-detected nodal disease (none, pelvic, para-aortic, or supraclavicular; P < .001). The hazard ratios for disease recurrence increased incrementally based on the most distant level of nodal disease: pelvic 2.40 (95% CI, 1.63 to 3.52), para-aortic 5.88 (95% CI, 3.80 to 9.09), and supraclavicular 30.27 (95% CI 16.56 to 55.34). CONCLUSION Nodal involvement detected by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and stratifies patient recurrence and survival outcomes.
Echinocandin use in lung transplant recipients (2018)

Our data suggest that echinocandins are utilized in approximately 18.3% of lung transplant recipients. They are the preferred second-line agents due to a lower adverse-effect profile compared to the azoles.
Diode-pumped continuous wave Tm,Ho:GdVO/sub 4/ laser in room temperature (2006)

Diode-pumped CW Tm, Ho:GdVO/sub 4/ laser was demonstrated in room temperature. It was confirmed that Tm, Ho:GdVO/sub 4/ is one of promising material for compact all solid-state 2 /spl mu/m source.
Correlation preserving map between bipartite states and temporal evolutions (2011)

The Hilbert space formalism of quantum theory manifests a map between bipartite states and time evolutions, known as Jamiolkowski isomorphism. We extend this map in a physical setting to prove the equality of spatial correlations in bipartite systems and temporal correlations in local systems. We show that these correlations can be observed using weak measurements. This result has several practical and conceptual implications such as manifestation of state independent decoherence, the correspondence between Bell and Leggett-Garg inequalities, multipartite systems, the statistical properties of evolutions in large systems, and computational gain, in evaluation of spatial correlations in large systems.
Evaluating the Potential of Native Ureolytic Microbes To Remediate a 90Sr Contaminated Environment (2010)

This study was a preliminary evaluation of ureolytically driven calcite precipitation and strontium coprecipitation for remediating (90)Sr contamination at the Hanford 100-N Area in Washington; in particular the approach is suitable for treating sorbed (90)Sr that could otherwise be a long-term source for groundwater contamination. Geochemical conditions at the site are compatible with long-term calcite stability, and therefore groundwater and sediment samples were examined to assess the ureolytic capabilities of the native microbiota. Quantitative assays detected up to 2 × 10(4) putative ureC gene copies mL(-1) in water and up to 9 × 10(5) copies g(-1) in sediment. The ureC assays and laboratory-based estimates of ureolytic activity indicated that the distribution of in situ ureolytic potential was very heterogeneous with depth and also that the ureolytic activity was predominantly associated with attached organisms. A mixed kinetic-equilibrium model was developed for the 100-N site to simulate urea treatment and predict strontium removal. Together, the microbial characterization data and modeling suggest that the site has the requisite biogeochemical characteristics for application of the calcite precipitation remediation approach for (90)Sr.
Soft-matter capacitive sensor for measuring shear and pressure deformation (2013)

We introduce a soft-matter sensor that measures elastic pressure and shear deformation. The sensor is composed of a sheet of elastomer that is embedded with fluidic parallel-plate capacitors. When the elastomer is pressed or sheared, the electrodes of the embedded capacitors come closer together or slide past each other, respectively, leading to a change in capacitance. The magnitude and direction of the shear deformation is established by comparing the change in capacitance of multiple embedded capacitors. We characterize the soft sensor theoretically and experimentally. Experiments indicate that 2D shear and pressure deformation can be discriminated with approximately 500 μm and 5 kPa sensitivity, respectively. The theoretical predictions and experimental results are in reasonable agreement. We also propose improvements to the fabrication method in order to facilitate integration of soft-matter sensing with wearable electronics.
PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells (2009)

RNA interference (RNAi) holds great promise for the treatment of inherited and acquired diseases, provided that safe and efficient delivery systems are available. Herein we report that structurally flexible triethanolamine (TEA) core PAMAM dendrimers are able to deliver an Hsp27 siRNA effectively into prostate cancer (PC-3) cells by forming stable nanoparticles with siRNA, protecting the siRNA nanoparticles from enzymatic degradation, and enhancing cellular uptake of siRNA. The Hsp27 siRNA resulted in potent and specific gene silencing of heat-shock protein 27, an attractive therapeutic target in castrate-resistant prostate cancer. Silencing of the hsp27 gene led to induction of caspase-3/7-dependent apoptosis and inhibition of PC-3 cell growth in vitro. In addition, the siRNA-dendrimer complexes are non-cytotoxic under the conditions used for siRNA delivery. Altogether, TEA core PAMAM dendrimer-mediated siRNA delivery, in combination with RNAi that specifically targets Hsp27, may constitute a promising approach for combating castrate-resistant prostate cancer, for which there is no efficacious treatment.