gebhart/patrepeval huggingface dataset:
State Space Model-Based Parameter Estimation Methods And Some Applicatons (1989)

This paper reviews state space model-based methods for signal processing applications. A state space frame-work is shown to provide a convenient tool for exposing and exploiting structure inherent in many model based methods. It is also shown that there exist state space methods which are robust to noise in data, and to numerical errors. From a computational point of view, the methods are often less complex than existing competing methods. Futhermore they only involve matrix operations which are suitable for systolic/wavefront implementation.
Multi-modal electron microscopy study on decoherence sources and their stability in Nb based superconducting qubit (2022)

Niobium is commonly used for superconducting quantum systems as readout resonators, capacitors, and interconnects. The coherence time of the superconducting qubits is mainly limited by microwave dissipation attributed to two-level system defects at interfaces, such as the Nb/Si and Nb/air interface. One way to improve the Nb/air interface quality is by thermal annealing, as shown by extensive studies in 3D superconducting radio frequency (SRF) cavities. However, it is unclear how the microstructure and chemistry of the interface structures change during heat treatment. To address this knowledge gap, we comprehensively characterized Nb films deposited on Si wafers by physical vapor deposition, including (1) an Nb film from a transmon and (2) an Nb film without any patterning step, using an aberration-corrected transmission electron microscope. Both Nb films exhibit columnar growth with strong [110] textures. There is a double layer between the Nb film and Si substrate, which are amorphous niobium silicides with different Nb and Si concentrations. After in-situ heating of the heterostructure at 360°C inside the microscope, the composition of the double layers at the Nb-Si interface remains almost the same despite different thickness changes. The initial amorphous niobium oxide layer on Nb surface decomposes into face-centered cubic Nb nanograins in the amorphous Nb-O matrix upon heating.
Biological networks with singular Jacobians: their origins and adaptation criteria (2021)

ABSTRACT This work is focused on Ordinary Differential Equations(ODE)-based models of biochemical systems that possess a singular Jacobian manifesting in non-hyperbolic equilibria. We show that there are several classes of systems that exhibit this behavior: a)systems with monomial-type interaction terms and b)systems with linear or nonlinear conservation laws. While models derived from mass-action principles often present with linear conservation laws stemming from the underlying biologic rationale, nonlinear conservation laws are more subtle and harder to detect. Nevertheless, in both situations the corresponding ODE system will contain non-hyperbolic equilibria. While having a potentially more complex dynamics and falling outside of the scope of existing theoretical frameworks, this class of systems can still exhibit adapting behavior associated with certain nodes and inputs. We derive a generalized adaptation condition that extends to singular systems and is compatible with both single-input/single-output and multiple-input/multiple-output settings. The approach explored herein, based on the notion of Moore-Penrose pseudoinverse, is tested on several synthetic systems that are shown to exhibit homeostatic behavior but are not covered by existing methods. These results highlight the role of the network structure and modeling assumptions when understanding system response to input and can be helpful in discovering intrinsic relationships between the nodes.
Quantitative, Sensitive Analysis of DNA and RNA (2008)

DNA or RNA sequences that contain useful information about disease risk, disease occurrence, therapeutic response, and probable prognosis are potentially valuable biomarkers. They can be accessed by biopsy, or in ideal cases non-invasively from easily accessible fluids like blood or urine. Tolls are available for biomarker discovery, validation, and clinical use. Discovery usually requires whole genome analysis, and currently this is done with either nucleic acid arrays (DNA chips) or sequencing. Validation requires high quality data scalability to large numbers of samples. Clinical utility normally needs a high degree of automation, and for non-invasive approaches, great experimental sensitivity and specificity but on small numbers of samples. No one platform can efficiently span the broad range of requirements and project sizes. SEQUENOM uses an automated mass spectrometry platform for the quantitative analysis of DNA and RNA in a variety of settings including genotyping, genecopy number measurements, gene expression, epigenetics, and automated bacterial and viral identification. In collaboration with Amit Meller at Boston University, SEQUENOM is developing optically detected nanospores as a companion platform for its mass spectrometry offering. Both platform use similar homogeneous solution biochemistry to prepare samples. Both platforms depend on vary rapid digital signal processing for real time data analysis and interpretation. The nanopore method uses pores large enough to pass single-stranded DNA but too small to pass double strands. Hence pore passage strips off one of the DNA stands, and optical method are used to detect changes in fluorophores on this strand or attached to reporter probes, as it is stripped. We expect that, when mature, the nanopore method will be extremely const effective for whole genome analysis of genotypes, gene expression, epigenetics, and whole genome sequencing. A key aspect of the nanopore method is its speed. Post sample preparation, many analyses may require only seconds of instrument time.
An efficient algorithm to calculate sample and rank selection probabilities for weighted median filters (2002)

Sample and rank selection probabilities are important in the analysis of weighted median filters as well as in comparing linear and nonlinear filters. We propose a new, efficient algorithm to calculate these probabilities for weighted median filters. The computational savings of this new algorithm are substantial and compare favorably with other known algorithms.
Piecewise Bilinear models for feedback error learning: On-line feedforward controller design (2013)

Feedback error learning is an on-line learning strategy of inverse dynamics. It sequentially acquires an inverse model of a plant through feedback control actions. The inverse model is usually implemented as a Neural Network, however we propose a new approach to implement the FEL control scheme through Piecewise Bilinear models. We present an on-line sequential learning algorithm for feedforward controller design. We also propose an algorithm for off-line identification of a pseudo-inverse model of a plant to use as an initial feedforward controller before its learning. We will prove the applicability of PB models to implement the FEL scheme through illustrative examples.
Epoxidation with m-chloroperbenzoic acid. Analytical method for determining unsaturation of olefins and polymers (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEpoxidation with m-chloroperbenzoic acid. Analytical method for determining unsaturation of olefins and polymersPatricia. Dreyfuss and Joseph P. KennedyCite this: Anal. Chem. 1975, 47, 4, 771–774Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/ac60354a026https://doi.org/10.1021/ac60354a026research-articleACS PublicationsRequest reuse permissionsArticle Views320Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection (2021)

Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection might be protected from reinfection. However, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical symptoms and limited viral replication in the lungs.
DETERMINATION OF THE DIELECTRIC CONSTANT OF CdS BY ELLIPSOMETRY, INTERFEROMETRY AND BY OPTICAL EXCITATION OF SURFACE PLASMONS (1983)

Three complementary methods, ellipsometry, interferometry and surface plasmon (SP) excitation, are used to determine the dielectric constant of CdS deposited on a silver substrate over the wavelength range 700-450 nm
Application of Plastic Fiber Optics to Automobiles (1967)

&lt;div class="htmlview paragraph"&gt;The availability of plastic fiber optics light-energy-transmitting material in long continuous lengths has made possible its use in automotive lighting and remote indicating systems. This paper presents a general history of the program and a discussion of the current applications and future possibilities. Also, the paper outlines some of the benefits to be gained by the use of fiber optics and guides for its application.&lt;/div&gt;
On the role of artificial intelligence in medical imaging of COVID-19 (2021)

Although a plethora of research articles on AI methods on COVID-19 medical imaging are published, their clinical value remains unclear. We conducted the largest systematic review of the literature addressing the utility of AI in imaging for COVID-19 patient care. By keyword searches on PubMed and preprint servers throughout 2020, we identified 463 manuscripts and performed a systematic meta-analysis to assess their technical merit and clinical relevance. Our analysis evidences a significant disparity between clinical and AI communities, in the focus on both imaging modalities (AI experts neglected CT and ultrasound, favoring X-ray) and performed tasks (71.9% of AI papers centered on diagnosis). The vast majority of manuscripts were found to be deficient regarding potential use in clinical practice, but 2.7% (n = 12) publications were assigned a high maturity level and are summarized in greater detail. We provide an itemized discussion of the challenges in developing clinically relevant AI solutions with recommendations and remedies.
CP-93,129: A Potent and Selective Agonist for the Serotonin (5-HT1B) Receptor and Rotationally Restricted Analog of RU-24,969 (1991)

The in vitro and in vivo characteristics of CP-93,129 [Structure 1 in Figure 1, 3-(1,2,5,6-tetrahydropyrid-4-yl)-pyrrolo[3,2-b]pyrid-5-one] are described. This rotationally restricted phenolic analog of RU-24,969 is a potent (15 nm) and selective (200 × vs. the 5-HT1A receptor, 150 × vs. the 5-HT1D receptor) functional agonist for the 5-HT1B receptor. Direct infusion of CP-93, I29 into the paraventricular nucleus of the hypothalamus of rats significantly inhibits food intake, implicating the role of 5-HT1B receptors in regularing feeding behavior in rodents. CP-93,129 has also been shown to be biochemically discriminatory in its ability to selectively inhibit forskolin-stimulated adenylate cyclase activity only at the 5-HT1B receptor. The source of the selectivity of CP-93,129 appears to lie in the ability of a pyrrolo[3,2-b]pyrid5-one to act as a rotationally restricted bioisosteric replacement for 5-hydroxyindole.
Synthetic Studies on the 1,6-Methano[10]annulene Skeleton: A New Route That Provides Derivatives Substituted at the Bridge and on the Annulene Ring (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Studies on the 1,6-Methano[10]annulene Skeleton: A New Route That Provides Derivatives Substituted at the Bridge and on the Annulene RingDavid G. Barrett, Gui-Bai Liang, D. Tyler McQuade, John M. Desper, Kurt D. Schladetzky, and Samuel H. GellmanCite this: J. Am. Chem. Soc. 1994, 116, 23, 10525–10532Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00102a020https://doi.org/10.1021/ja00102a020research-articleACS PublicationsRequest reuse permissionsArticle Views332Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Drug Derived Fluorescent Probes for the Specific Visualization of Cannabinoid Type 2 Receptor - A Toolbox Approach (2019)

Cannabinoid type 2 receptor (CB2R) is a fundamental part of the endocannabinoid signaling system (eCB system), and is known to play an important role in tissue injury, inflammation, cancer and pain. In stark contrast to its significance, the underlying signaling mechanisms and tissue expression profiles are poorly understood. Due to its low expression in healthy tissue and lack of reliable chemical tools, CB2R visualization in live cells remains uncharted. Here we report the development of a drug derived toolbox of highly potent, CB2R-selective fluorescent probes based on reverse design. Extensive validation in several applications such as CB2R detection in flow cytometry and time-resolved imaging, and the development of a novel fluorescent-based TR-FRET assay to generate kinetic and equilibrium binding data demonstrate the high versatility of our toolbox. These probes are the first to preserve affinity and efficacy in both human and mouse CB2R, a crucial aspect for preclinical translatability, and to enable imaging of CB2R internalization in living cells using confocal microscopy.
Application of a Droplet Evaporation Model to Aerodynamic Size Measurement of Drug Aerosols Generated by a Vibrating Mesh Nebulizer (2010)

Results from the droplet evaporation model shows that the mass median aerodynamic diameter (MMAD) measured by the NGI is strongly influenced not only by the initial droplet size, but also by factors such as the temperature and humidity of entrained air, the nebulizer output rate, and the entrained air flow rate. The modeling and experimental results indicate that the influence of these variables on size measurements may be reduced significantly by refrigerating the impactor down to 5°C prior to measurement. The same data also support the conclusion that for the case of nebulized drug solutions, laser diffraction spectrometry provides a meaningful droplet sizing approach, that is simpler and less susceptible to such droplet evaporation artifacts.
Management API for SET Event Streams (2017)

Security Event Token (SET) delivery requires event receivers to
indicate to event transmitters the subjects about which they wish to
receive events, and how they wish to receive them. This specification
defines an HTTP API for a basic control plane that event transmitters
can implement and event receivers may use to manage the flow of events
from one to the other.
An Aromatic Hydroxylation Reaction Catalyzed by a Two-component FMN-dependent Monooxygenase (2005)

The ActVA-ActVB system from Streptomyces coelicolor isatwo-component flavin-dependent monooxygenase that belongs to an emerging class of enzymes involved in various oxidation reactions in microorganisms. The ActVB component is a NADH:flavin oxidoreductase that provides a reduced FMN to the second component, ActVA the proper monooxygenase. In this work, we demonstrate that the ActVA-ActVB system catalyzes the aromatic monohydroxylation of dihydrokalafungin by molecular oxygen. In the presence of reduced FMN and molecular oxygen, the ActVA active site accommodates and stabilizes an electrophilic flavin FMN-OOH hydroperoxide intermediate species as the oxidant. Surprisingly, we demonstrate that the quinone form of dihydrokalafungin is not oxidized by the ActVA-ActVB system, whereas the corresponding hydroquinone is an excellent substrate. The enantiomer of dihydrokalafungin, nanaomycin A, as well as the enantiomer of kalafungin, nanaomycin D, are also substrates in their hydroquinone forms. The previously postulated product of the ActVA-ActVB system, the antibiotic actinorhodin, was not found to be formed during the oxidation reaction.
Isothermal Desorption Kinetics of Crystalline H2O, H218O, and D2O Ice Multilayers (2003)

The isothermal desorption rates of crystalline H2O, H218O, and D2O ice multilayers were measured over a temperature range from 175 to 190 K. The desorption rates were measured with optical interferometry using ice multilayers grown epitaxially on a Ru(001) surface in an ultrahigh vacuum chamber. The Arrhenius parameters for the desorption of H2O and H218O were identical within experimental error. For H2O, the preexponential was ν = 1032.6±0.3 cm-2 s-1 and the activation energy was E = 13.9 ± 0.2 kcal mol-1. For H218O, the preexponential was ν18 = 1032.4±0.3 cm-2 s-1 and the activation energy was E18 = 13.8 ± 0.2 kcal mol-1. Despite the near equivalence in the Arrhenius parameters, H218O desorbed at a rate that was slower by ∼9% throughout the range of temperatures. In contrast, the desorption rate of D2O was slower by 49−62% compared with H2O over the measured temperature range. The Arrhenius parameters for the desorption of D2O were νD = 1033.4±0.5 cm-2 s-1 and ED= 14.8 ± 0.4 kcal mol-1. A transition state model was developed to explain the measured desorption kinetics. The transition state model predicts that total molecular mass has only a small effect on the desorption kinetics because the mass differences among the isotopomers are small. On the other hand, the principal moments of inertia of the desorbing molecules have a large effect on the desorption rate. About each of the three axes, D2O has roughly twice the moment of inertia of H2O or H218O. This larger moment of inertia affects the desorption rate in two ways. First, surface bound D2O molecules have lower frequencies for hindered rotations. These lower frequencies result in less zero-point energy for the surface bound molecule and a larger desorption activation energy. Second, a transition state D2O molecule has a larger rotational partition function. This larger rotational partition function yields a larger preexponential for desorption.
SEGREGATED SOLUTION TECHNIQUE FOR SIMULATING THE TRANSIENT OPERATION OF HEAT PIPES (1994)

Simulating the transient operation of fully thawed heat pipes involves solving a highly nonlinear homogeneous two-phase flow problem, which necessitates the development of a stable and efficient numerical technique. In this work, various segregated numerical techniques are implemented, and their accuracy and computation time requirement are examined using experimental data of a water heat pipe. Best results are obtained using an iterative SIMPLEC-type segregated solution technique (HPTAM-Revised), which includes two internal iterative steps to resolve the pressure-velocity coupling and reduce the linearization errors of the kinetic theory relationship and equations of state. While all solution techniques examined performed the same in terms of accuracy, the HPTAM-Revised is 90 times faster than the basic noniterative SIMPLE-type approach in terms of CPU time. Also, using the iterative SIS solver, instead of the banded Gauss-elimination solver, for the discretized energy and momentum equations resulted in more than 50% savings in the CPU time for computational grids larger than 20 × 30.
Directional OCT Scans of the Macula Reveal Henle Fibre Layer-Related Imaging Patterns (2017)

Optical coherence tomography (OCT) has become an invaluable tool in ophthalmic decision making, driven in large part by the onset of modern intravitreal pharmacotherapies [1]. There are several artifacts potentially involved in the interpretation process of OCT scans, most of these are influenced by image quality [2] and the underlying retinal pathology itself [3]. A special type of artifact is the appearance of the typically hyperreflective Henle Fiber Layer (HFL) as a part of the outer nuclear layer (ONL) under specific imaging conditions [4], [5]. This artifact can be erroneously interpreted as a pathological structural alteration while it constitutes no retinal pathology. The appearance of the HFL is dependent on the imaging beam entrance at the pupil and the resultant oblique scanning of the macula. By changing the orientation of light incident on the retina, directional OCT (D-OCT) adds optical contrast to directionally reflective structures, visualizing the HFL [5].
Cyclen friction modifiers for boundary lubrication (2023)

Compositions comprising one or more cyclen compounds which can be structurally modified to affect anti-friction and anti-wear functionality.