gebhart/patrepeval huggingface dataset:
Fused Pyrrolo[2,3-c]carbazol-6-ones:  Novel Immunostimulants That Enhance Human Interferon-γ Activity (1997)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTFused Pyrrolo[2,3-c]carbazol-6-ones: Novel Immunostimulants That Enhance Human Interferon-γ ActivityRobert L. Hudkins, James L. Diebold, Thelma S. Angeles, and Ernest KnightView Author Information Departments of Medicinal Chemistry and Cell Biology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380 Cite this: J. Med. Chem. 1997, 40, 19, 2994–2996Publication Date (Web):September 12, 1997Publication History Received26 March 1997Published online12 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/jm9702037https://doi.org/10.1021/jm9702037rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views303Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antigens,Cancer therapy,Immunology,Peptides and proteins,Reaction products Get e-Alerts
Time-Resolved Electron Diffraction from Selectively Aligned Molecules (2009)

We experimentally demonstrate ultrafast electron diffraction from transiently aligned molecules in the absence of external (aligning) fields. A sample of aligned molecules is generated through photodissociation with femtosecond laser pulses, and the diffraction pattern is captured by probing the sample with picosecond electron pulses shortly after dissociation-before molecular rotation causes the alignment to vanish. In our experiments the alignment decays with a time constant of 2.6+/-1.2 ps.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF THE “POCKET” PORPHYRINS (1983)

Abstract Aus der Umsetzung des Bromids (Ia) mit Diethylmalonat wird ein Gemisch aus Di‐, Tetra‐ und Hexaestern (Ib) erhalten, aus dem sich nach Hydrolyse und Decarboxylierung die Tricarbonsäure als Trimethylester (Ic) (mit einer Gesamtausbeute von 28%) säulenchromatographisch abtrennen läßt . Das entsprechende Säurechlorid (Id) wandelt das Porphyrin (II) nach Einführung einer Schutzgruppe in das metallfreie "Pocket"‐Porphyrin (IIIc) um.
Enterobacteria‐Infected T Cells as Antigen‐Presenting Cells for Cytotoxic CD8 T Cells: A Contribution to the Self‐Limitation of Cellular Immune Reactions in Reactive Arthritis? (1997)

In enterobacteria-induced reactive arthritis (ReA), different T cell subsets play a role in the induction and maintenance of the synovitic process. Synovial fluid-derived alphabeta CD4, alphabeta CD8, and gammadelta T lymphocyte clones (TLC) that recognize Yersinia or Salmonella antigens on professional antigen-presenting cells (APC) have been characterized, and T cells themselves can function as nonprofessional APC. T cells were infected with the facultatively intracellular, arthritogenic enterobacterium Yersinia enterocolitica O:3. A CD8 TLC isolated from a patient with Yersinia-induced ReA recognized and efficiently lysed autologous and allogeneic Yersinia-infected T cells. Infected cytotoxic T lymphocytes (CTL) had a reduced lytic capacity against syngeneic and allogeneic infected target cells, suggesting that the infection of CTL by bacteria may represent a mechanism of immune escape. In ReA, antigen presentation by T cells may modify the antibacterial immune response and may also contribute to network control mechanisms of T cell-mediated cytotoxicity.
Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study (2023)

Serum sAXL, IL-6, and YKL-40 relate to different AD features, including the degree of neuropathology and cognitive functioning. This may suggest that peripheral blood signatures correspond to specific stages of the disease. As serum markers did not reflect the corresponding CSF protein levels, our data highlight the need to interpret serum inflammatory markers depending on the respective protein's specific biology and cellular origin. These marker-specific differences will have to be considered to further define and interpret blood-based inflammatory profiles for AD research.
Serum copper and zinc measurements in patients with osteogenic sarcoma (1978)

Serum copper level (SCL), serum zinc level (SZL), and SCL/SZL ratio were measured in 18 patients with biopsy-proven osteogenic sarcoma. Measurements were made on sequentially collected serum samples beginning prior to the institution of therapy and continuing periodically until documented relapse. All patients were treated by curative resection and adjuvant therapy consisting of high dose methotrexate (with leucovorin rescue) with or without BCG immunotherapy. The SCL, SZI, and SCL/SZL determinations were made using proton-induced x-ray fluorescence spectrometry. SCL was significantly elevated (p less than .0001) in the 18 patients with primary untreated osteogenic sarcoma )173 +/- 30 microgram/dl) compared with a sex and age-matched normal group (115 +/- 16 microgram/dl). A significantly different SZL was not found, however, so that an elevated SCL/SZL ratio in the osteogenic sarcoma patients was primarily due to the altered SCL. SCL and SCL/SZL did not change significantly following curative surgery or become more abnormal in those patients who developed recurrent disease. The SCL and SCL/SZL were noted to be markedly elevated in those patients receiving BCG therapy, raising concern regarding the specificity of these tests as markers of tumor activity. SCL, SZL, and SCL/SZL did not appear useful as markers of tumor activity in patients with osteogenic sarcoma.
Relevant image pre-filtering in automatic image orientation correction (2010)

In this paper, we propose a method for improving automatic image orientation correction by relevant image pre-filtering. We find out that users feel more stress on false positives than false negatives in automatic correction through a user study. A strategy based on this finding is devised and our method realizes this strategy by filtering out irrelevant images which are likely to become false positives. The accuracy evaluations with actual personal photos show improvements of the precision from 94% to 98% at the recall ratio of 15%, and from 97.5% to 100% at the recall ratio of 10%. A subjective survey concludes the proposed pre-filtering alleviates the users' annoyance for automatic orientation corrections.
Dynamic gain compensation in saturated erbium-doped fiber amplifiers (1991)

Dynamic compensation of low-frequency gain fluctuations in saturated erbium-doped fiber amplifiers is demonstrated. This compensation, based on a simple feedback-loop scheme makes it possible to reduce transient gain fluctuations efficiently across the whole amplifier bandwidth using only a low-power optical feedback signal. Such an, automatic gain control technique could be applied to suppress data packet interference due to traffic bursts in multiple-access networks, as well as in the implementation of long-haul fiber systems using erbium fiber amplifiers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reactive Tetrablock Copolymers Containing Glycidyl Methacrylate. Synthesis and Morphology Control in Epoxy−Amine Networks (2003)

Polystyrene-block-polybutadiene-block-poly(glycidyl methacrylate) (SBG) and polystyrene-block-polybutadiene-block-poly(methyl methacrylate)-block-poly(glycidyl methacrylate) copolymers (SBMG) were synthesized by sequential living anionic polymerization in tetrahydrofuran (THF). SBMG copolymers were used as modifiers for epoxy thermosets based on the diglycidyl ether of bisphenol A (DGEBA). Different techniques including differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and optical cloud point measurements have been used to demonstrate the advantage of having a reactive copolymer to finely tune and control the morphology of nanostructured materials. The FT-IR and DSC studies were used to follow both the kinetics of reaction of the reactive block G with the epoxy−amine system and of cross-linking of the epoxy−amine system. They give an interesting insight into the problem of factors governing the expulsion of the methacrylic block out of the epoxy−amine phase during network formation. Morphological characteristics revealed by TEM appear to be closely related to the optical properties of these composites.
Capturing 2&amp;#189;D Depth and Texture of Time-Varying Scenes Using Structured Infrared Light (2006)

In this paper, we describe an approach to simultaneously capture visual appearance and depth of a time-varying scene. Our approach is based on projecting structured infrared (IR) light. Specifically, we project a combination of (a) a static vertical IR stripe pattern, and (b) a horizontal IR laser line sweeping up and down the scene; at the same time, the scene is captured with an IR-sensitive camera. Since IR light is invisible to the human eye, it does not disturb human subjects or interfere with human activities in the scene; in addition, it does not affect the scene’s visual appearance as recorded by a color video camera. Vertical lines in the IR frames are identified using the horizontal line, intra-frame tracking, and inter-frame tracking; depth along these lines is reconstructed via triangulation. Interpolating these sparse depth lines within the foreground silhouette of the recorded video sequence, we obtain a dense depth map for every frame in the video sequence. Experimental results corresponding to a dynamic scene with a human subject in motion are presented to demonstrate the effectiveness of our proposed approach.
Supplementary Figure 7. from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma (2023)

&lt;p&gt;Supplementary Figure 7. LDM PTX did not affect the splenic tumor mass in SCID mice xenotransplanted with EGI-1 cells, in vivo.&lt;/p&gt;
2D infrared phased array leaky-wave antenna (2016)

An infrared phased array antenna design using leaky-wave elements is presented. The leaky-wave mechanism is utilized to produce scanning in the φ=90° plane while phase tuning by varying distance between the leaky-wave elements produces scanning in the φ=0° plane. The combination of these two allows for 2D beam scanning. The applications of such 2D phased arrays lies in highly directive, broadband transmission and reception.
Developing registries of volunteers: key principles to manage issues regarding personal information protection: Figure 1 (2010)

Much biomedical research cannot be performed without recruiting human subjects. Increasingly, volunteer registries are being developed to assist researchers with this challenging task. Yet, volunteer registries raise confidentiality issues. Having recently developed a registry of volunteers, the authors searched for normative guidance on how to implement the principle of confidentiality. The authors found that the protection of confidentiality in registries are based on the 10 key elements which are elaborated in detail in the Canadian Standards Association Model Code. This paper describes how these 10 detailed key principles can be used during the developmental stages of volunteer registries.
Engineering cell-fluorescent ion track hybrid detectors (2013)

The Cell-Fit-Hybrid Detector system is a promising platform for a multitude of studies linking biological response to energy deposition at high level of optical microscopy resolution.
Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy (2018)

Microglia are the primary immune cells residing in the central nervous system (CNS), where they play essential roles in the health and disease. Depending on the CNS inflammatory milieu, they exist in either resting or activated states. Chronic neuroinflammation mediated by activated microglia is now considered to be a common characteristic shared by many neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, which currently pose a significant socioeconomic burden to the global healthcare system. Accumulating evidence has indicated protein kinases (PKs) as important drug targets for therapeutic interventions of these detrimental diseases. Here, we review recent findings suggesting that selected PKs potentially participate in microglia-mediated neuroinflammation. Taming microglial phenotypes by modulating the activity of these PKs holds great promise for the development of disease-modifying therapies for many neurodegenerative diseases.
a-InGaZnO Thin-film Transistor as an Oxygen Gas Sensor with In-Situ Electrical Characterization (2020)

Wide band gap metal oxide semiconductors have been explored for a plethora of applications in recent years [1]. Thin film transistors (TFTs) especially have found extensive utility in environmental sensors and flexible electronics for modern devices. Amorphous Indium Gallium Zinc Oxide (a-IGZO) is a wide band gap metal oxide semiconductor with ideal properties for next generation sensors. It&#x0027;s transparent thin film coupled with wide band gap and high field effect mobility provides an ideal platform for such sensors. It&#x0027;s stability and high mobility gives it a major advantage over the organic TFTs that have been traditionally used for such sensing applications. Oxygen sensors has seen large demand recently owing to the modernization of agricultural methods and in biomedical applications where it is of critical importance. In the present work an a-IGZO TFT is fabricated and demonstrated for oxygen sensing with in-situ electrical characterization. a-IGZO thin films are prepared by simple, low-cost solution processing. The a-IGZO TFT is used to sense oxygen (O<inf>2</inf>) gas and ppm level detection is achieved. The effect of change in electrical characteristics of IGZO TFTs with oxygen adsorption is utilized to achieve high sensitivity [2]. The saturation drain current <tex>$(\mathrm{I}_{\text{Dsat}})$</tex> increment of 20 uA/ppm and V<inf>th</inf> shift of 100mV/ppm in presence of oxygen is observed.
Contribution of CD8+T Cells to Containment of Viral Replication and Emergence of Mutations inMamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys (2008)

Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.
Activation of the c-abl Oncogene by Viral Transduction or Chromosomal Translocation Generates Altered c-abl Proteins with Similar In Vitro Kinase Properties (1985)

The v-abl protein of Abelson murine leukemia virus is a tyrosine-specific kinase. Its normal cellular homolog, murine c-abl, does not possess detectable tyrosine kinase activity in vitro. Previously, we have detected tyrosine kinase activity in vitro for an altered c-abl gene product (c-abl P210) in the K562 human chronic myelogenous leukemia cell line. The expression of this variant c-abl gene product correlates with chromosomal translocation and amplification of the c-abl gene in K562 cells. Like v-abl, c-abl P210 is a fusion protein containing non-abl sequences near the amino terminus of c-abl. We compared the in vitro tyrosine kinase activity of c-abl P210 with that of wild-type murine v-abl. The remarkable similarities of these two proteins with respect to cis-acting autophosphorylation, trans-acting phosphorylation of exogenous substrates, and kinase inhibition, using site-directed abl-specific antisera, suggested that c-abl P210 could function similarly to v-abl in vivo. In addition, c-abl P210 possessed an associated serine kinase activity in immunoprecipitates. The serine kinase activity was not inhibited by site-directed, abl-specific antisera that inhibit the tyrosine kinase activity, suggesting that the serine kinase activity is not an intrinsic property of c-abl P210. Thus, the activation of the c-abl gene in a human leukemia cell line may have functional consequences analogous to activation of the c-abl gene in Abelson murine leukemia virus.
Minimum number of information gatherers to ensure full observability of a dynamic social network: A structural systems approach (2014)

This paper studies the problem of identifying the minimum number of entities (agents), referred to as information gatherers, that are able to infer all the states in a dynamical social network. The information gatherers can be, for instance, service providers and the remaining agents the clients, each comprising several dynamic states associated with the services and personal information. The problem of identifying the minimum number of information gatherers can constitute a way to create coalitions to oversee the entire state of the system, and consequently the behavior of the agents in the social network. The dynamical social network is assumed to be modelled as a linear time-invariant system, and we will make use of the structural systems concept, i.e., by considering only the sparsity pattern (location of zeroes/non-zeroes) of the system coupling matrix. As a consequence, the design guarantees derived hold for almost all numerical parametric realizations of the system. In this paper, we show that this problem is NP-hard: in addition, we provide a reduction of the coalition problem to a minimum set covering problem that, in practice, leads to efficient (polynomial complexity) approximation schemes for solving the coalition problem with guaranteed optimality gaps. Finally, an example is provided which illustrates the analytical findings.
Advances in SiCN-SiCN Bonding with High Accuracy Wafer-to-Wafer (W2W) Stacking Technology (2018)

Results are presented of recent studies in material exploration for W2W bonding and advanced W2W alignment carried out as a holistic approach to enable a robust ultra-fine pitch interconnect for 3Dsystem-on-chip (SoC) technology. Various characterization methods have been employed, including electron-spin-resonance (ESR) monitoring of dangling-bond-type defects, invoked to compare SiCN-SiCN and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> bonding bonding strength in terms of the the evolution of chemical bond densities at the interface. Furthermore, sub-200 nm W2W overlay performance has been demonstrated to cope with 3D interconnect scaling and stringent contact requirements. State-of-the-art overlay performance is achieved by the enabling features of the W2W aligner while the incoming wafer characteristics are monitored. The study provides a positive outlook to 3D SoC technological realization and sub-μm pitch scaling solutions.
The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin fold-Rab interface and association with PI-3-P-positive membranes (2014)

To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1-Ccz1 complex as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7. To address the possible GEF mechanism, we generated a homology model of the predicted longin domains of Mon1 and Ccz1 using the Rab-binding surface of the TRAPP complex as a template. On the basis of this, we identified mutations in both yeast Mon1 and Ccz1 that block Ypt7 activation, without affecting heterodimer formation and intracellular localization of Mon1 and Ccz1 at endosomes. Strikingly, the activity of the isolated Mon1-Ccz1 complex for Ypt7 is highly stimulated on membranes, and is promoted by the same anionic phospholipids such as phosphatidylinositol-3-phosphate (PI3P), which also support membrane association of the GEF complex. Our data imply that the GEF activity of the Mon1-Ccz1 complex towards Rab7/Ypt7 requires the interface formed by their longin domains and profits strongly from its association with the organelle surface.
P4–075: Fibrillar Aβ triggers insulin degrading enzyme (IDE) over–expression by glial cells in old Tg2576 mice (2006)

It was proposed that IDE participates in the clearance of amyloid β (Aβ) in the brain and its low expression or activity may be relevant for the progression of Alzheimer's disease (AD). To study the profile of IDE during the neurodegenerative process in transgenic mice (Tg2576) brains, which carry the amyloid precursor protein with the Swedish mutation. Tg2576 mice and non–Tg (NTg) littermates of 4.5, 11 and 16 months of age (m) (n=4/group) were used to determine IDE protein and activity levels by ELISA, western–blot (WB) and immunoprecipitation assays. IDE transcripts were quantified by competitive RT–PCR. Brain sections were subjected to immunohistochemistry with anti–IDE, anti–Aβ, anti–GFAP and L. esculentum lectin. At 16 m Tg2576 mice showed a significant 2–fold increment in IDE protein levels as compared to 11 m (612 ± 54.3 vs. 291.96 ± 23.7 ng/mg, respectively) that was fully active using 125I–insulin as a substrate. No significant differences were found in the amount of IDE transcripts in whole brain homogenates, suggesting that IDE increment was not due to a widespread increase in its mRNA levels. The peak of soluble IDE was in synchrony with a sharp accumulation of SDS–soluble Aβ40 (355.046 ng/mg ± 2.096), and massive Aβ deposition into plaques. Moreover, at this stage, IDE appeared surrounding amyloid deposits within GFAP–positive astrocytes and activated microglia. This suggested that IDE was locally over–expressed by glial cells in the context of an inflammatory response triggered by fibrillar Aβ. To explore this possibility, primary rat astrocytes were used to test IDE levels after exposure to soluble or fibrillar Aβ. After treatment with 5 μM fibrillar Aβ, IDE protein and transcripts increased 2–fold as detected by WB, immunofluorescence and RT–PCR compared to soluble Aβ or control cultures. Our results suggest that the defective clearance of Aβ due to IDE lower expression or activity is not an accelerating factor in Tg2576 mice amyloid deposition. Moreover, IDE over–expression associated to late–stages of the neuropathologic process in this animal model may be part of an inflammatory response, suggesting a new role for IDE in the brain that deserves future investigation.