gebhart/patrepeval huggingface dataset:
Self‐Assembled Nanodielectrics for High‐Speed, Low‐Voltage Solution‐Processed Polymer Logic Circuits (2015)

Solution‐processed polymer‐based logic circuits are typically associated with high operating voltage and slow switching speeds. Here, polymer field‐effect transistors (PFETs) fabricated on hybrid self‐assembled nanodielectric (SAND) structures are reported, the latter consisting of alternating organic–inorganic layers exhibiting low leakage current (≈10 −9 A cm −2 ) and high capacitance (≈0.8 μF cm −2 ). Suitable device engineering, controllable dielectric parameters, and interface energetics enable PFET operation at ±1 V, field‐effect mobility ( μ FET ) &gt; 2.0 cm 2 V −1 s −1 , subthreshold swing ≈100 mV dec −1 , and switching response ≈150 ns. These performance parameters are orders of magnitude higher than similar devices fabricated from other polymer dielectrics. Inverter and NAND logic circuits fabricated from these SAND‐based PFETs possess voltage gain up to 38 and maximum‐frequency bandwidth of 2 MHz. A systematic study comparing different classes of dielectric and semiconducting material attributes the enhanced performance to improved relaxation dynamics of the SAND layer and tunable chemically functionalized interfaces.
Self-routing of wavelength packets using an all-optical wavelength shifter and QPSK subcarrier routing control headers (1996)

We demonstrate a novel wavelength-router that directs self-routing optical packets, containing microwave subcarrier-multiplexed control information, from an input wavelength-path to one of four destination wavelength-paths. The router incorporates (1) an all-optical wavelength shifter, based on cross-gain compression of a semiconductor optical amplifier, and (2) a low-speed electronic control-header processor. Each packet is comprised of concurrently transmitted 1-Gb/s NRZ baseband payload data and a 50-Mb/s control header, QPSK-encoded onto a 1.5-GHz subcarrier. We show 10/sup -9/ BER results of packets routed to each of the four wavelength-paths. The maximum wavelength shift is 23 nm, and the inter-packet guard time is 20 ns.
Carbon based nanomaterials for tissue engineering of bone: Building new bone on small black scaffolds: A review (2019)

Tissue engineering is a rapidly-growing approach to replace and repair damaged and defective tissues in the human body. Every year, a large number of people require bone replacements for skeletal defects caused by accident or disease that cannot heal on their own. In the last decades, tissue engineering of bone has attracted much attention from biomedical scientists in academic and commercial laboratories. A vast range of biocompatible advanced materials has been used to form scaffolds upon which new bone can form. Carbon nanomaterial-based scaffolds are a key example, with the advantages of being biologically compatible, mechanically stable, and commercially available. They show remarkable ability to affect bone tissue regeneration, efficient cell proliferation and osteogenic differentiation. Basically, scaffolds are templates for growth, proliferation, regeneration, adhesion, and differentiation processes of bone stem cells that play a truly critical role in bone tissue engineering. The appropriate scaffold should supply a microenvironment for bone cells that is most similar to natural bone in the human body. A variety of carbon nanomaterials, such as graphene oxide (GO), carbon nanotubes (CNTs), fullerenes, carbon dots (CDs), nanodiamonds and their derivatives that are able to act as scaffolds for bone tissue engineering, are covered in this review. Broadly, the ability of the family of carbon nanomaterial-based scaffolds and their critical role in bone tissue engineering research are discussed. The significant stimulating effects on cell growth, low cytotoxicity, efficient nutrient delivery in the scaffold microenvironment, suitable functionalized chemical structures to facilitate cell-cell communication, and improvement in cell spreading are the main advantages of carbon nanomaterial-based scaffolds for bone tissue engineering.
Image guidance in the focal treatment of prostate cancer (2012)

Although early results of phase I focal therapy trials are encouraging, long-term oncological outcomes remain to be elucidated. Incorporation of these technological advances into large prospective trials is needed to establish focal therapy as an important asset in the urologist's armamentarium against prostate cancer.
Localization Performance of 1-Bit Passive Radars in NB-IOT Applications (2019)

Location-based services form an important use-case in emerging narrowband Internet-of-Things (NB-IoT) networks. Critical to this offering is an accurate estimation of the location without overlaying the network with additional active sensors. The massive number of devices, low power requirement, and low bandwidths restrict the sampling rates of NB-IoT receivers. In this paper, we propose a novel low-complexity approach for NB-IoT target delay estimation in cases where one-bit analog-to-digital-converters (ADCs) are employed to sample the received radar signal instead of high-resolution ADCs. This problem has potential applications in the design of inexpensive NB-IoT radar and sensing devices. We formulate the target estimation as a multivariate fractional optimization problem and solve it via Lasserre's semi-definite program relaxation. Numerical experiments suggest feasibility of the proposed approach yielding high localization accuracy with a very low number of l-bit samples.
Electrocardiographic Changes During Cesarean Section (1993)

A Holter monitor was used to record ST segment changes during cesarean section in 170 consecutive healthy parturients starting 2 h before and ending 3 h after surgery. Lumbar epidural anesthesia (LEA, n = 120) or subarachnoid anesthesia (SA, n = 50) was used. Transthoracic 2-D echocardiograms were obtained in 30 patients from the LEA group. ST depression or elevation occurred 160 times in 44 patients from both groups. Ninety-eight percent of these changes occurred between induction of anesthesia and the end of surgery, with 78% of the episodes registering -1 mV. In the LEA group, the number of episodes tended to increase after delivery, but in the SA group, the frequency remained constant. ST segment depression was recorded in 38% and 14% of patients in the LEA and SA groups, respectively (P < 0.05, x2 analysis). No wall motion abnormality was noted in the echocardiogram during ST segment depression. Neither the 12-lead electrocardiogram nor plasma myocardial specific creatine kinase suggested myocardial damage. The operative events, alone or in combination, including hypertension, tachycardia, hypotension, bradycardia, air embolism (precordial Doppler) were neither specific nor sensitive as predictors of ST segment change (stepwise logistic regression). Tachycardia was associated with ST segment changes in 10% of time epochs (5 min) (P = 0.05, x2 analysis). Thus, ST segment changes during cesarean section are not caused by myocardial ischemia and are not of any clinical consequence.
The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and d -amphetamine and is not self-administered (2001)

Growing attention has been directed towards the potential involvement of the dopamine D3 receptor (D3R) in modulating effects of psychomotor stimulants. BP 897 (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide; aka BP 4.897 and DO897) is amongst the most selective partial agonists for the D3R receptor thus far reported. BP 897 was tested for its ability to support self-administration in rhesus monkeys (0.3-30 microg/kg) and for its ability to produce cocaine- and D-amphetamine-like discriminative stimulus effects in mice (0.01-17 mg/kg i.p.). BP 897 was not self-administered above vehicle and saline levels in any of the four monkeys tested, and produced less than 30% generalization from either the cocaine or D-amphetamine stimulus. When BP 897 was administered before administrations of cocaine or D-amphetamine, percent drug-lever selections were reduced. These results suggest that BP 897 has a profile of activity suitable for consideration as a potential treatment for cocaine dependency disorders.
Fifth European Paediatric Motility Meeting (2011)

Benninga, M.A.; Peeters, B.; Hennekam, R.C.; Smout, A.; Wenzl, T.G.; van der Pol, R.; Smits, M.; van Wijk, M.P.; Hassall, E.; Thomson, M.A.; Nurko, S.; Vandenplas, Y.; Veereman-Wauters, G.; De Greef, E.; Devreker, T.; Hauser, B.; Heymans, H.S.A.; Rohof, W.O.; Boeckxstaens, G.E.; Bredenoord, A.J.; Rommel, N.; van Avesaat, M.; Keszthelyi, D.; Masclee, A.A.M.; Omari, T.; Kritas, S.; Systerman, B.; Khurana, S.; de Jong, J.R.; Szajewska, H.; Kelly, D.; Mulder, I.E.; van Diest, S.A.; Stanisor, O.I.; de Jonge, W.J.; van den Wijngaard, R.M.; Bonilla, S.; Saps, M.; Yacob, D.; Di Lorenzo, C.; van Tilburg, M.; Rutten, J.M.T.M.; Vlieger, A.M.; Kirsch, I.; Hotta, R.; Thapar, N.; Aziz, Q.; Scott, S.M.; Lunniss, P.J.; Burgers, R.; Southwell, B.R.; Giannetti, E.; Sciorio, E.; Staiano, A.; Bongers, M.E.J.; de Jonge, W.J.; Mugie, S.M.
Totalsynthese von (±)-Gelsemin (1999)

Eine komplexe molekulare Reorganisation (1→2), eine Sequenz aus Aza-Cope-Umlagerung und Mannich-Cyclisierung und eine neuartige intramolekulare Heck-Reaktion der tetrasubstituierten Doppelbindung eines vinylogen Carbamats sind die Schlüsselschritte einer neuen Totalsynthese von (±)-Gelsemin 3. MOM=Methoxymethyl, DBU=1,8-Diazabicyclo[5.4.0]undec-7-en.
Photolysis of hydrogen sulfide in the presence of dimethylsilane (1974)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTPhotolysis of hydrogen sulfide in the presence of dimethylsilaneA. G. Alexander, R. W. Fair, and O. P. StrauszCite this: J. Phys. Chem. 1974, 78, 3, 203–207Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://doi.org/10.1021/j100596a001RIGHTS & PERMISSIONSArticle Views34Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (508 KB) Get e-Alerts
<title>Evaluation of endmember selection techniques and performance results from ORASIS hyperspectral analysis</title> (1998)

In this work, we generate ROC curves on real and synthetic scenes and develop scoring methods to evaluate the performance of the ORASIS hyperspectral algorithm. The goal of this effort is to improve the overall performance of ORASIS, focusing on the endmember selection methods. ROC curve evaluations have been performed on hyperspectral data sets from different scenes. We have scored by target and by target pixel. A scene generator has been developed allowing many features: combination of real or synthetic background and multiple, distinct targets; user-defined angle of target spectrum to background subspace; and user-specified non-uniform target/background transparency.
Expression of lin seed: impact of process parameters on oil quality (2012)

11th World Filtration Congress, WFC11, Gratz, Austria, April 16-20, 2012.
Research letterCloning of a Vero toxin (VT1, Shiga-like toxin I) gene from a VT1-converting phage isolated from Escherichia coli O157:H7 (1987)

Vero toxin (VT1, Shiga-like toxin I)-converting phages were induced with UV light from Escherichia coli O157:H7 strain 83–1386. A non-toxigenic E. coli C600 strain, lysogenized with a toxin-converting phage (86-02), produced VT1. A phage solution was prepared from the lysogenized E. coli C600 (86-02) strain and the phage DNA was prepared.

EcoRI-fragments of the phage DNA were ligated with EcoRI-digested pBR325ΔTc and it was transformed into E. coli strain MC1061. Transformants with VT1 production commonly contained a 5.1-kb EcoRI-fragment. The restriction map of the EcoRI-fragment was prepared and it was found that a 2.1-kb BamHI-BglII fragment encoded VT1 production.
Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy (2021)

This position paper focusses on the pathophysiology, diagnosis and management of women diagnosed with a cardiomyopathy, or at risk of heart failure (HF), who are planning to conceive or present with (de novo or previously unknown) HF during or after pregnancy. This includes the heterogeneous group of heart muscle diseases such as hypertrophic, dilated, arrhythmogenic right ventricular and non-classified cardiomyopathies, left ventricular non-compaction, peripartum cardiomyopathy, Takotsubo syndrome, adult congenital heart disease with HF, and patients with right HF. Also, patients with a history of chemo-/radiotherapy for cancer or haematological malignancies need specific pre-, during and post-pregnancy assessment and counselling. We summarize the current knowledge about pathophysiological mechanisms, including gene mutations, clinical presentation, diagnosis, and medical and device management, as well as risk stratification. Women with a known diagnosis of a cardiomyopathy will often require continuation of drug therapy, which has the potential to exert negative effects on the foetus. This position paper assists in balancing benefits and detrimental effects.
Light-regulated, tissue-specific immunophilins in a higher plant. (1994)

In addition to their application in organ transplantation, immunosuppressive drugs are valuable tools for studying signal transduction in eukaryotic cells. Using affinity chromatography, we have purified immunosuppressive drug receptors (immunophilins) from fava bean. Proteins belonging to both major classes of the immunophilin family identified from animal sources [FK506- and rapamycin-binding proteins (FKBPs) and cyclophilins] were present in this higher plant. FKBP13, the most abundant FKBP family member in leaf tissues, was not detected in root tissues, whereas other FKBPs were present in both tissues. While the abundance of cyclophilin A in leaves was similar to that in roots, cyclophilin B/C was expressed at a much higher level in leaf tissues than in root tissues. Subcellular localization of immunophilins in mesophyll cells showed that chloroplasts contained FKBP13 and cyclophilin B/C but not other members, which explains the preferential expression of these two proteins in leaves over roots. The abundance of chloroplast-localized immunophilins, FKBP13 and cyclophilin B/C, was regulated by light. Although etiolated leaves produced detectable levels of cyclophilin B/C, they did not express FKBP13. Illumination of etiolated plants dramatically increased the expression of both FKBP13 and cyclophilin B/C. The light-induced expression of FKBP13 is closely correlated with the accumulation of chlorophyll in the leaf tissue. Our findings suggest that FKBP13 and cyclophilin B/C may play a specific role in chloroplasts.
High-power fiber laser sources for remote sensing (2013)

Pulse fiber lasers constitute a promising optical transmitter technology for remote sensing applications characterized by tight size, power consumption, and ruggedness constraints. In this paper, we review laser architecture and component solutions that support power scaling of efficient fiber-based sources towards long-range operation consistent with imaging and/or chemical sensing from space-based platforms.
Magic-Angle-Spinning NMR of the Drug Resistant S31N M2 Proton Transporter from Influenza A (2012)

We report chemical shift assignments of the drug-resistant S31N mutant of M2(18-60) determined using 3D magic-angle-spinning (MAS) NMR spectra acquired with a (15)N-(13)C ZF-TEDOR transfer followed by (13)C-(13)C mixing by RFDR. The MAS spectra reveal two sets of resonances, indicating that the tetramer assembles as a dimer of dimers, similar to the wild-type channel. Helicies from the two sets of chemical shifts are shown to be in close proximity at residue H37, and the assignments reveal a difference in the helix torsion angles, as predicted by TALOS+, for the key resistance residue N31. In contrast to wild-type M2(18-60), chemical shift changes are minimal upon addition of the inhibitor rimantadine, suggesting that the drug does not bind to S31N M2.
Device aware high-speed transceiver design in planar and FinFet technologies (2014)

This paper studies the interaction between devices in advanced CMOS processes and the analog circuits used in high-speed transceivers. It describes the impact of variation on the design with both active and passive devices, and devises circuit techniques to mitigate their impact on the performance of transceivers. A case study of transceiver components in 20nm planar and 16nm FinFET processes are used to illustrate the interactions. With proper design techniques, the transceiver in 20nm operates up to 16.3Gb/s and achieves measured bit error rate lower than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-15</sup> over 28dB channels.
Empirical determination of the energy loss of heavy quarks in nuclear collisions at RHIC and LHC energies (2021)

Heavy quarks produced in the heavy ion collisions loose energy while propagting in the hot partonic matter which finally fragment to heavy ($D$ or $B$) mesons. The energy loss suffered by the heavy quarks is imprinted in the nuclear modification factor as a function of transverse momenta ($p_T$) of these heavy mesons. An alternate measure of in-medium energy loss comes through the effective shift in transverse momentum spectra of hadrons recorded in nucleus-nucleus collisions when it is compared to the same in proton-proton collisions. We start by parametrizing invariant momentum yields of heavy mesons in p+p collisions. The fit function from p+p collisions and measured nuclear modification factor in heavy ion collisions are then utilised to obtain the shift in the transeverse mass $Δm_T$ of heavy mesons produced at the RHIC and LHC experiments.The energy loss $Δm_T$ so obtained is found to scale with the transverse mass ($m_T$) of heavy mesons through a power law at different energies and centralities of collisions. We have also calculated using theoretical formalism, the total energy loss suffered by a charm quark in quark-gluon plasma produced in Pb~+~Pb collisions at the LHC energies. The evolution of the plasma is described by (2+1) dimensional longitudinal boost-invariant ideal hydrodynamics. It is found that the total energy loss of charm quarks scales with the transverse mass of charm quarks through a similar power law which supports our empirical analysis of energy loss.
Inhibition of luciferase expression by synthetic hammerhead ribozymes and their cellular uptake (1999)

Two synthetic hammerhead ribozymes, one unmodified and the other with 2"-modifications and four phosphorothioate groups, targeting a single GUA site in the luciferase mRNA, were compared for their inhibition of gene expression in cell cultureand their cellular uptake was also analysed. A HeLa X1/5 cell line stably expressing luciferase, under an inducible promoter, was treated with these ribozymes by liposome-mediated transfection to determine their activity. Luciferase expression in cells was inhibited to approximately 50% with little difference between the unmodified and the 2"-modified ribozyme. A similar degree of inhibition was observed with two catalytically inactive ribozymes, indicating that inhibition was mainly due to an antisense effect. A ribozyme carrying a cholesterol moiety, applied to the cells without carrier, showed no inhibition. Northern blotting indicated a similar amount of cellular uptake of all ribozymes. The unmodified ribozyme was essentially evenly distributed between cytoplasm and nucleus, whereas a higher proportion of the phosphorothioate-containing ribozyme was observed in the nucleus. Fluorescence microscopy, including confocal microscopy using 5"-fluorescein-labelled ribozymes, showed that the unmodified and 2"-modified ribozymes were present in the cytoplasm and in the nucleus to a similar extent, whereas the fluorescence of the phosphorothioate-containing ribozyme was much stronger in the nucleus. Both ribozymes inhibited luciferase expression to a comparable degree, suggesting that the ribozyme in the nucleus did not contribute significantly to the inhibition. Ribozymes with a cholesterol moiety were predominantly trapped in the cell membrane, explaining their inability to interfere with gene expression.
Increased Electron-Accepting and Decreased Electron-Donating Capacities of Soil Humic Substances in Response to Increasing Temperature (2017)

The electron transfer capacities (ETCs) of soil humic substances (HSs) are linked to the type and abundance of redox-active functional moieties in their structure. Natural temperature can affect the chemical structure of natural organic matter by regulating their oxidative transformation and degradation in soil. However, it is unclear if there is a direct correlation between ETC of soil HS and mean annual temperature. In this study, we assess the response of the electron-accepting and -donating capacities (EAC and EDC) of soil HSs to temperature by analyzing HSs extracted from soil set along glacial-interglacial cycles through loess-palaeosol sequences and along natural temperature gradients through latitude and altitude transects. We show that the EAC and EDC of soil HSs increase and decrease, respectively, with increasing temperature. Increased temperature facilitates the prevalence of oxidative degradation and transformation of HS in soils, thus potentially promoting the preferentially oxidative degradation of phenol moieties of HS or the oxidative transformation of electron-donating phenol moieties to electron-accepting quinone moieties in the HS structure. Consequently, the EAC and EDC of HSs in soil increase and decrease, respectively. The results of this study could help to understand biogeochemical processes, wherein the redox functionality of soil organic matter is involved in the context of increasing temperature.