gebhart/patrepeval huggingface dataset:
Organolanthanide-Catalyzed Carbon-Heteroatom Bond Formation. Observations on the Facile, Regiospecific Cyclization of Aminoalkynes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganolanthanide-Catalyzed Carbon-Heteroatom Bond Formation. Observations on the Facile, Regiospecific Cyclization of AminoalkynesYanwu Li, Peng-Fei Fu, and Tobin J. MarksCite this: Organometallics 1994, 13, 2, 439–440Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://doi.org/10.1021/om00014a015Request reuse permissionsArticle Views339Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (288 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of [(HIPTNCH2CH2)3N]Cr Compounds (HIPT = 3,5-(2,4,6-i-Pr3C6H2)2C6H3) and an Evaluation of Chromium for the Reduction of Dinitrogen to Ammonia (2006)

Red-black [HIPTN3N]Cr (1) ([HIPTN3N]3- = [(HIPTNCH2CH2)3N]3- where HIPT = 3,5-(2,4,6-i-Pr3C6H2)2C6H3 = HexaIsoPropylTerphenyl) can be prepared from CrCl3, while green-black [HIPTN3N]Cr(THF) (2) can be prepared from CrCl3(THF)3. Reduction of {1|2} (which means either 1 or 2) with potassium graphite in ether at room temperature yields [HIPTN3N]CrK (3) as a yellow-orange powder. There is no evidence that dinitrogen is incorporated into 1, 2, or 3. Compounds that can be prepared readily from {1|2} include red [HIPTN3N]CrCO (4), blood-red [HIPTN3N]CrNO (6), and purple [HIPTN3N]CrCl (7, upon oxidation of {1|2} with AgCl). The dichroic (purple/green) Cr(VI) nitride, [HIPTN3N]CrN (8) was prepared from Bu4NN3 and 7. X-ray studies have been carried out on 4, 6, and 7, and on two co-crystallized compounds, 7 and [HIPTN3N]CrN3 (65:35) and [HIPTN3N]CrN3 and 8 (50:50). Exposure of a degassed solution of {1|2} to an atmosphere of ammonia does not yield "Cr(NH3)" as a stable and well-behaved species analogous to Mo(NH3). An attempt to reduce dinitrogen under conditions described for the catalytic reduction of dinitrogen by [HIPTN3N]Mo compounds with 8 yielded a substoichiometric amount (0.8 equiv) of ammonia, which suggests that some ammonia is formed from the nitride but none is formed from dinitrogen.
Surface-directed spinodal decomposition (1991)

The spinodal decomposition of mixtures of poly(ethylenepropylene) (PEP) and perdeuterated poly-(ethylenepropylene) has been studied near the surface using forward-recoil spectrometry. Instead of the composition waves with randomly oriented wave vectors (and random phases) found in the bulk, we observe composition waves with wave vectors normal to, and which propagate inwards from, the surface, maintaining coherence for several wavelengths. We argue that these surface-directed spinodal decomposition waves are caused by the preferential attraction of the d-PEP to the surface.
Multiphoton spectroscopy and high spatial resolution measurements with EFISH (2003)

Summary form only given. Nonlinear optical polymers developed for electro-optical and all-optical signal processing applications offer a unique opportunity for the inspection of future generations of silicon based electronic and optoelectronic devices with feature sizes in the 100 nm range and radiated fields with bandwidth in excess of 100 GHz. The need for such resolutions is anticipated by the year 2010. We demonstrate that such high resolutions are compatible with modern nonlinear polymers, ultrafast lasers and high-resolution optical metrology. We demonstrate that under two-photon resonance enhancement, centrosymmetric thin films less than 100 nm thick are capable of mapping low frequency fields at the surface of a semiconductor device with sensitivities in excess of 1 mV//spl mu/m and sub-micron resolution.
The Ephrin A1–EphA2 System Promotes Cardiac Stem Cell Migration After Infarction (2011)

Ephrin A1 promotes the motility of EphA2-positive hCSCs, facilitates their migration to the area of damage, and enhances cardiac repair. Thus, in situ stimulation of resident hCSCs with ephrin A1 or their ex vivo activation before myocardial delivery improves cell targeting to sites of injury, possibly providing a novel strategy for the management of the diseased heart.
Induced differentiation of cancer cells: second generation potent hybrid polar compounds target cell cycle regulators (1996)

Program of Cell Biology and Genetics, DeWitt Wallace Research Laboratory, Memorial Sloan-Kettering Cancer Center and the Sloan- Kettering Division of the Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
CMOS Integrated Nanophotonics – Enabling Technology for Exascale Computing Systems (2011)

CMOS Integrated Nanophotonics allows ultra-dense monolithic single-chip integration of optical and electrical functions. This technology can enable future Exaflops supercomputers by connecting racks, modules, and chips together with ultra-low power massively parallel optical interconnects.
Comprehensive molecular characterization of colorectal cancer reveals genomic predictors of immune cell infiltrates. (2015)

3505 Background: Colorectal cancer (CRC) is a molecularly heterogeneous disease that arises and progresses in the context of a complex microenvironment. Tumor immune cell infiltrates have been shown to be associated with an improved CRC-specific and overall survival. However, the genomic features of CRC that determine the number and types of immune infiltrates remain largely uncharacterized. Methods: We performed Whole Exome Sequencing and microsatellite instability (MSI) analysis on primary CRCs from 689 patients (pts) identified from two large prospective cohorts, the Nurses’ Health Study and the Health Professionals Follow-Up Study. We also immunohistochemically characterized the immune infiltrate (peritumoral, intratumoral periglandular, Crohn’s-like, tumor-infiltrating, and total lymphocyte score) and conducted tissue microarray imaging analysis for T-cell subsets (CD3+, CD8+, CD45RO+, FoxP3+). We utilized a novel computational pipeline to calculate tumor neoantigen load (peptides resulting from somatic mutations and recognized by the immune system as foreign) and subsequently correlated the tumor neoantigen load with the aforementioned immune variables and with pt survival. Results: When compared to microsatellite-stable cancers, MSI-high tumors expressed significantly more neoantigens (P < 2e-16). Tumor neoantigen load significantly correlated with total lymphocytic score in the primary CRCs (P = 4.9e-9) and was most significantly associated with tumor infiltrating lymphocytes (P = 1.6e-15). Among T-cell subsets, tumor neoantigen load was only significantly associated with the CD45RO+ T-cell subset (P = 0.0003). Higher tumor neoantigen load predicted significantly improved CRC-specific and overall survival (P = 0.014 and P = 0.048, respectively). Conclusions: In the large prospective study of molecularly characterized CRCs, tumor neoantigen load predicts greater tumor-infiltrating lymphocytes and memory T-cell infiltration and represents a novel genomic predictor of CRC survival. Our findings link tumor genomics to specific immune response elements and have implications for the therapeutic manipulation of the latter in CRC.
Modelling of the internet on as level (2020)

ping, traceroute, DNS, SSL/TLS, NTP and HTTP Anchors: enhanced probes with more measurement capacity: Constantly probed & regional targets for user-defined measurements Volunteers that host probes earn credits to perform own measurements 6 | AS/Internet M&S model 9390 Active Probes (green)
Time resolved study of the HiPIMS palladium, platinum and gold post-discharge (2015)

Communication par affiche
Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells (2020)

IL-17-producing Th17 cells are implicated in the pathogenesis of rheumatoid arthritis (RA) and TNF-α, a proinflammatory cytokine in the rheumatoid joint, facilitates Th17 differentiation. Anti-TNF therapy ameliorates disease in many patients with rheumatoid arthritis (RA). However, a significant proportion of patients do not respond to this therapy. The impact of anti-TNF therapy on Th17 responses in RA is not well understood. We conducted high-throughput gene expression analysis of Th17-enriched CCR6<sup>+</sup>CXCR3<sup>-</sup>CD45RA<sup>-</sup> CD4<sup>+</sup> T (CCR6<sup>+</sup> T) cells isolated from anti-TNF-treated RA patients classified as responders or nonresponders to therapy. CCR6<sup>+</sup> T cells from responders and nonresponders had distinct gene expression profiles. Proinflammatory signaling was elevated in the CCR6<sup>+</sup> T cells of nonresponders, and pathogenic Th17 signature genes were up-regulated in these cells. Gene set enrichment analysis on these signature genes identified transcription factor USF2 as their upstream regulator, which was also increased in nonresponders. Importantly, short hairpin RNA targeting <i>USF2</i> in pathogenic Th17 cells led to reduced expression of proinflammatory cytokines IL-17A, IFN-γ, IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as transcription factor T-bet. Together, our results revealed inadequate suppression of Th17 responses by anti-TNF in nonresponders, and direct targeting of the USF2-signaling pathway may be a potential therapeutic approach in the anti-TNF refractory RA.
Optical Anapole Mode with Planar Metamaterials (2017)

Natural toroidal molecules, such as biomolecules [1] and proteins [2], possess toroidal dipole moments that are hard to be detected, which leads to extensive studies of artificial toroidal materials. Metamaterials [3-4] are sub-wavelength artificial structures that can be specifically designed to manipulate the intensity of induced electromagnetic multidipoles. Recently, toroidal metamaterials [5-6] have been widely investigated to enhance toroidal dipole moments while the other multipoles are eliminated due to the spacial symmetry. However, to effectively excite a toroidal dipole, a specific excitation method is necessary since a closed-loop of induced magnetic dipoles in a toroidal metamaterial weakly interact with the external wave. This is a key issue that has to be carefully taken into account in existing toroidal experiments. Moreover, most of generated toroidal dipole moments are either aligned vertically to the substrate surface or embedded in a dielectric, leading to another constraint for further applications. In this paper, we present a novel design for a toroidal metamaterial with multilayered structures, which composed of a gold dumbbell-shaped aperture and a vertical split-ring resonator (VSRR). The induced toroidal dipoles show several advantages like free-standing and vertically oscillating configuration that are distinguishable from previously reported works. It is worth to mention that the non-radiating from the destructive interference from the toroidal and electric dipoles can also be generated in our proposed structures.
Self-termination of contactless photo-electrochemical (PEC) etching on aluminum gallium nitride/gallium nitride heterostructures (2020)

Abstract Contactless photo-electrochemical (PEC) etching was successfully demonstrated on AlGaN/GaN heterostructures using a K 2 S 2 O 8 aqueous solution. The etching was conducted by a simple method such as just dipping the sample with Ti-cathode pads into the solution under UVC illumination. The etching morphology of the AlGaN surface was very smooth with an root mean square roughness of 0.24 nm. The etching was self-terminated in the AlGaN layer, whose residual thickness was 5 nm uniformly throughout the etched region. These contactless PEC etching features are promising for the fabrication of recessed-gate AlGaN/GaN high-electron-mobility transistors with high recessed-gate thickness reproducibility.
Intravascular Enhancement With Identical Iodine Delivery Rate Using Different Iodine Contrast Media in a Circulation Phantom (2013)

This phantom study demonstrates that constant injection parameters (IDR, overall iodine load) lead to robust enhancement patterns, regardless of the contrast material used. Higher iodine concentration itself does not lead to higher attenuation levels. These results may stimulate a shift in paradigm toward clinical usage of contrast media with lower iodine concentrations (eg, 240 mg iodine/mL) in individual tailored contrast protocols. The use of low-iodine concentration contrast media is desirable because of the lower viscosity and the resulting lower injection pressure.
Thin Film Transistors for Flexible Electronics: Contacts, Dielectrics and Semiconductors (2011)

The development of low temperature, thin film transistor processes that have enabled flexible displays also present opportunities for flexible electronics and flexible integrated systems. Of particular interest are possible applications in flexible sensor systems for unattended ground sensors, smart medical bandages, electronic ID tags for geo-location, conformal antennas, radiation detectors, etc. In this paper, we review the impact of gate dielectrics, contacts and semiconductor materials on thin film transistors for flexible electronics applications. We present our recent results to fully integrate hybrid complementary metal oxide semiconductors comprising inorganic and organic-based materials. In particular, we demonstrate novel gate dielectric stacks and semiconducting materials. The impact of source and drain contacts on device performance is also discussed.
Influence of the Curing and Annealing Temperatures on the Properties of Solution Processed Tin Oxide Thin Films (2021)

We report the effect of the curing (Tcuring) and annealing (Tanneal) temperatures on the structural, electrical, and optical properties of solution processed tin oxide. Tanneal was varied from 300 to 500 °C, and Tcuring from 200 °C to Tanneal. All Tanneal lead to a polycrystalline phase, but the amorphous phase was observed at Tanneal = 300 °C and Tcuring ranging from 250 to 300 °C. This could be explained by the melting point of the precursor (SnCl2), occurring at 250 °C. The crystallinity can be effectively controlled by the annealing temperature, but the curing temperature dramatically affects the grain size. We can reach grain sizes from 5–10 nm (Tcuring = 200 °C and Tanneal = 300 °C) to 30–50 nm (Tcuring = 500 °C and Tanneal = 500 °C). At a fixed Tanneal, Hall mobilities, carrier concentration, and conductivity increased with the curing temperature. The Hall mobility was in the range of 1 to 9.4 cm2/Vs, the carrier concentration was 1018 to 1019 cm−3, and the conductivity could reach ~20 S/cm when the grain size was 30–50 nm. The optical transmittance, the optical bandgap, the refractive index, and the extinction coefficient were also analyzed and they show a correlation with the annealing process.
Human Factors and Safety Challenges in Transitioning to an Automated Electric Transportation System (2011)

The transportation system of the United States has had significant impacts on the nation’s development, both geographically and economically. Yet inefficiencies and inherent dangers of that system cost billions and perhaps trillions of dollars every year, as well as thousands of lost lives. Automated Electric Transportation (AET) is a solution which addresses and has the potential to resolve many of those issues, particularly in relation to human factors in driving, for future transportation. However, in developing this new transportation system, new challenges arise that must be addressed. Therefore, the purpose of this paper is to provide a brief overview of the concept of AET and emphasize its potential impacts on transportation safety and mobility. It also addresses specific challenges that this new transportation system will face as it moves through its development. The discussion of these challenges, including deployment/transition strategy, environmental hurdles, incident response, and future expansion provides a springboard for further research and development in Automated Electric Transportation .
Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index (2010)

In the quest for safe, efficacious kinase inhibitors as drugs, selectivity is often assessed early using kinase profiling panels. Here we present a selectivity index based on thermodynamics principles that can help in analysis of the resulting data. The "partition" selectivity index is easy to calculate and is applicable in certain situations where other widely used indices are not. It is uniquely useful in analysis of small, focused selectivity panel data frequently encountered in medicinal chemistry hit-to-lead and lead optimization. For larger "kinome" panels, the partition index allows assessment of selectivity relative to a kinase or multiple kinases of interest.
Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection (2018)

A comprehensive 3D model for intravitreal and SC drug injection is developed to provide a framework and platform for testing drug delivery routes and sustained delivery devices for new and existing drugs.
On the Limits of Pseudo Ground Truth in Visual Camera Re-localisation (2021)

Benchmark datasets that measure camera pose accuracy have driven progress in visual re-localisation research. To obtain poses for thousands of images, it is common to use a reference algorithm to generate pseudo ground truth. Popular choices include Structure-from-Motion (SfM) and Simultaneous-Localisation-and-Mapping (SLAM) using additional sensors like depth cameras if available. Re-localisation benchmarks thus measure how well each method replicates the results of the reference algorithm. This begs the question whether the choice of the reference algorithm favours a certain family of re-localisation methods. This paper analyzes two widely used re-localisation datasets and shows that evaluation outcomes indeed vary with the choice of the reference algorithm. We thus question common beliefs in the re-localisation literature, namely that learning-based scene coordinate regression outperforms classical feature-based methods, and that RGB-D-based methods outperform RGB-based methods. We argue that any claims on ranking re-localisation methods should take the type of the reference algorithm, and the similarity of the methods to the reference algorithm, into account.
Potent inhibitor of the human rhinovirus (HRV) 3C protease containing a backbone modified glutamine (1995)

Based on the common cleavage site (between glutamine and glycine) of the human rhinovirus 3C protease, a series of potent inhibitors of this serine protease containing a backbone modified glutamine has been synthesized.
Verification of RF SoCs: RF, Analog, Baseband and Software (2006)

Single-chip RF SoCs are seeing widespread acceptance in wireless applications. In this paper we address the issue of design verification of such complex ICs that accept input close to the RF carrier frequency and are analyzed for receiver BER performance and transmitter output distortion and phase noise by processing several thousand packets of baseband information while compensation algorithms are simultaneously executed. No comprehensive methodology exists to date for designing such complex systems. This paper present a novel approach that allows building complex RF SoC systems based on VHDL modeling and simulation and opens up major avenues of model development for RF and analog circuits. This approach has been successfully applied to verify two generations of digital RF processors in deep-submicron technologies
Shoulderpads and shagpile: architectural referencing in the television series Gloss (2009)

Before Television New Zealand closed its drama department in 1988 and production became outsourced, 55 episodes of the memorable series Gloss had been made at in the Browns Bay sound studio in Auckland. Screening between 1987 and 1990, the series was based on the experiences of writer Rosemary McLeod's years in the internecine world of women's magazines. Revolving around the machinations of fictional magazine editor and high priestess of fashion Maxine Redfern and her dynastic family, the series deployed architectural detail as readily as it did Liz Mitchell's costume designs in order to evoke an era of conspicuous consumption. Sumptuous production designs characterised the sets, with the interiors of the offices of the fictional magazine Gloss itself remarkable for their evocation of glamour and glitz. Domestic spaces inhabited by the extraordinary characters also conveyed materialism and superficiality through furnishings and design, doing much to contribute to characterisation of Aucklanders as immoral show-offs with poor value systems. The trappings of success in a materialistic world included the worst features of postmodern architecture, it would seem. As the title song for the series went, “It's the gilt off the gingerbread/The icing on the cake/It's monuments and mirrorglass/The city's on the make/Devil take the hindmost/So no one counts the cost/Such a sweet seduction/Glosssssssss."
Intracellular replication of the well-armed pathogen Burkholderia pseudomallei (2016)

The Burkholderia genus contains a group of soil-dwelling Gram-negative organisms that are prevalent in warm and humid climates. Two species in particular are able to cause disease in animals, B. mallei primarily infects Equus spp. and B. pseudomallei (BPS), that is able to cause potentially life-threatening disease in humans. BPS is naturally resistant to many antibiotics and there is no vaccine available. Although not a specialised human pathogen, BPS possesses a large genome and many virulence traits that allow it to adapt and survive very successfully in the human host. Key to this survival is the ability of BPS to replicate intracellularly. In this review we highlight recent advances in our understanding of the intracellular survival of BPS, including how it overcomes host immune defenses and other challenges to establish its niche and then spread the infection. Knowledge of these mechanisms increases our capacity for therapeutic interventions against a well-armed foe.
Progesterone effects during sequential hormone replacement therapy (2003)

In women without prior PMS natural progesterone caused negative mood effects similar to those induced by synthetic progestogens.