gebhart/patrepeval huggingface dataset:
On the Indoor Beamformer Design With Reverberation (2014)

Beamforming remains to be an important technique for signal enhancement. For applications in open space, the transfer function describing waves propagation has an explicit expression, which can be employed for beamformer design. However, the function becomes very complex in an indoor environment due to the effects of reverberation. In this paper, this problem is discussed. A method based on the image source method (ISM) is applied to model the room impulse responses (RIRs), which will act as the transfer function between source and sensor. The indoor beamformer design problem is formulated as a minimax optimization problem. We propose and study several optimization models based on the L1-norm to design the beamformer. We found that it is advantageous to separate early and late reverberations in the design process and better designs can be achieved. Several numerical experiments are presented using both simulated data and real recordings to evaluate the proposed methods.
Coordinated Generation Expansion Planning for Transmission and Distribution Systems (2021)

This paper presents a coordinated approach to investments in a wide range of generation and storage technologies on the transmission and distribution system levels by coupling two generation expansion planning models. This coupling allows to account for both the centralized decision maker’s perspective as well as the end consumer’s perspective. We provide the location, type and capacity of new assets and account for the increased need for flexibility in case of investments in intermittent RES. The capabilities of the developed methodology are demonstrated using Swiss system data for the period 2020–2050. We show that the phased-out nuclear power will be gradually substituted by high shares of distributed PV and investigate the impacts of the replacement on the Swiss electricity exports/imports, electricity prices, investment costs and end-consumers’ savings as well as the hourly dispatch.
ChemInform Abstract: Acyclic Stereoselection. Part 34. Stereoselection in the Michael Addition Reactions. (1986)

Abstract Die Enolether (I) reagieren mit den chiralen Enonen (II) in Gegenwart von TiCl 4 weitgehend stereoselektiv zu den Addukten (III).
Continuous flow fabrication of green graphene oxide in aqueous hydrogen peroxide (2022)

Highly processible graphene oxide (GO) has a diversity of applications as a material readily dispersed in aqueous media. However, methods for preparing such free-standing GO use hazardous and toxic reagents and generate significant waste streams. This is an impediment for uptake of GO in any application, for developing sustainable technologies and industries, and overcoming this remains a major challenge. We have developed a robust scalable continuous flow method for fabricating GO directly from graphite in 30% aqueous hydrogen peroxide which dramatically minimises the generation of waste. The process features the continuous flow thin film microfluidic vortex fluidic device (VFD), operating at specific conditions while irradiated sequentially by UV LED than a NIR pulsed laser. The resulting 'green' graphene oxide (gGO) has unique properties, possessing highly oxidized edges with large intact sp<sup>2</sup> domains which gives rise to exceptional electrical and optical properties, including purple to deep blue emission of narrow full width at half maximum (<35 nm). Colloidally stable gGO exhibits cytotoxicity owing to the oxidised surface groups while solid-state films of gGO are biocompatible. The continuous flow method of generating gGO also provides unprecedented control of the level of oxidation and its location in the exfoliated graphene sheets by harnessing the high shear topological fluid flows in the liquid, and varying the wavelength, power and pulse frequency of the light source.
Measurement of the conduction band discontinuities of InGaAsP/InP heterojunctions using capacitance–voltage analysis (1986)

The relationship between the conduction band discontinuity (ΔEc) and the band gap difference (ΔEg) of InGaAsP/InP heterojunctions is measured for the first time using capacitance–voltage analysis. It is found that ΔEc=(0.39±0.01)ΔEg over the entire spectrum of compositions of InGaAsP lattice matched to InP. This result is to be contrasted with those obtained for the GaAs/GaAlAs material system, where 60%–70% of the band gap difference between a particular composition of GaAlAs and GaAs appears in the conduction band. The measurements discussed in this work were made using novel organic-on-inorganic contact barrier devices. Due to the high energy barriers between certain organic materials and InGaAsP, high resolution measurements of the carrier concentrations, layer thicknesses, conduction band discontinuities, and other relevant parameters were made possible. Constructing wafer contour maps of the fixed charge density at the heterointerface (σ) using this technique indicated no systematic dependence of ΔEc on σ for σ&amp;lt;5×10 cm−2, as expected.
The Lean Woman (2002)

Lean, nonsmoking women enjoy an excellent health in not only anthropometric and metabolic factors, but also in neuroendocrine, endocrine, and psychological variables. The endocrine measurements suggest a well-functioning aromatase, which in turn might have a genetic background, contributing to health. The aromatase gene might be important for regulation of body fat mass.
Expression profiling of drug response - from genes to pathways (2006)

Understanding individual response to a drug-what determines its efficacy and tolerability-is the major bottleneck in current drug development and clinical trials. Intracellular response and metabolism, for example through cytochrome P-450 enzymes, may either enhance or decrease the effect of different drugs, dependent on the genetic variant. Microarrays offer the potential to screen the genetic composition of the individual patient. However, experiments are "noisy" and must be accompanied by solid and robust data analysis. Furthermore, recent research aims at the combination of high-throughput data with methods of mathematical modeling, enabling problem-oriented assistance in the drug discovery process. This article will discuss state-of-the-art DNA array technology platforms and the basic elements of data analysis and bioinformatics research in drug discovery. Enhancing single-gene analysis, we will present a new method for interpreting gene expression changes in the context of entire pathways. Furthermore, we will introduce the concept of systems biology as a new paradigm for drug development and highlight our recent research-the development of a modeling and simulation platform for biomedical applications. We discuss the potentials of systems biology for modeling the drug response of the individual patient.
207Pb NMR Chemical-Shift Tensors of the Lead (II) Halides and the Lead (II) Hydroxyhalides (1998)

The NMR properties of the solid lead (II) halides and the lead (II) hydroxyhalides are reported. The analysis shows extremely wide powder patterns in all cases except the lead (II) iodide. The results indicate that one should be able to distinguish the lead (II) halide from the corresponding lead (II) hydroxyhalide in a mixture.
Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in the Vasculature, Attenuates NF-κB Activation (2007)

These data suggest that UCHL1 may partially attenuate vascular remodeling through inhibition of NF-kappaB activity.
Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding (2014)

Amyotrophic lateral sclerosis (ALS), a fatal adult-onset degenerative neuromuscular disorder with a poorly defined etiology, progresses in an orderly spatiotemporal manner from one or more foci within the nervous system, reminiscent of prion disease pathology. We have previously shown that misfolded mutant Cu/Zn superoxide dismutase (SOD1), mutation of which is associated with a subset of ALS cases, can induce endogenous wild-type SOD1 misfolding in the intracellular environment in a templating fashion similar to that of misfolded prion protein. Our recent observations further extend the prion paradigm of pathological SOD1 to help explain the intercellular transmission of disease along the neuroaxis. It has been shown that both mutant and misfolded wild-type SOD1 can traverse cell-to-cell either as protein aggregates that are released from dying cells and taken up by neighboring cells via macropinocytosis, or released to the extracellular environment on the surface of exosomes secreted from living cells. Furthermore, once propagation of misfolded wild-type SOD1 has been initiated in human cell culture, it continues over multiple passages of transfer and cell growth. Propagation and transmission of misfolded wild-type SOD1 is therefore a potential mechanism in the systematic progression of ALS pathology.
Recent Progress in the Identification and Clinical Evaluation of Inhibitors of the Mitotic Kinesin KSP (2008)

Kinesin spindle protein (KSP), a mitotic kinesin responsible for bipolar spindle establishment and maintenance, is currently the target of intense research for the development of novel anticancer therapeutics. Several inhibitors of KSP have progressed into clinical trials and many others are in preclinical development. A majority of these inhibitors are ATP-uncompetitive and bind in an allosteric loop L5 binding pocket, but recently, inhibitors with an alternative mechanism of action (ATP-competitive) have also been identified and characterized. In this review, an update of the clinical trial results with ATP-uncompetitive KSP inhibitors is provided and recent progress in the identification of additional KSP inhibitors is discussed.
Paget's disease of the nipple. Immunohistochemical localization of milk fat globule membrane antigens (1985)

The authors have used the indirect immunoperoxidase technique to examine the presence and distribution of milk fat globule membrane antigens in 12 cases of mammary Paget's disease using two monoclonal antibodies, HMFG-1 and HMFG-2. These stain breast epithelial cells but do not stain normal epidermis. The Paget's cells showed a similar pattern of cytoplasmic staining to that seen in the underlying intraduct or invasive carcinoma, therefore confirming them to be malignant ductal cells. To support this one of the cases was stained with the antibody LE 61 which is specific for nonepidermal epithelial cytokeratins. The result was strongly positive in Paget's cells in the epidermis but not in squamous cells.
Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators (2010)

The majority of bacterial gene regulators bind as symmetric dimers to palindromic DNA operators of 12-20 base pairs (bp). Multimeric forms of proteins, including tetramers, are able to recognize longer operator sequences in a cooperative manner, although how this is achieved is not well understood due to the lack of complete structural information. Models, instead of structures, of complete tetrameric assembly on DNA exist in literature. Here we present the crystal structures of the multidrug-binding protein TtgV, a gene repressor that controls efflux pumps, alone and in complex with a 42-bp DNA operator containing two TtgV recognition sites at 2.9 Å and 3.4 Å resolution. These structures represent the first full-length functional tetrameric protein in complex with its intact DNA operator containing two continuous recognition sites. TtgV binds to its DNA operator as a highly asymmetric tetramer and induces considerable distortions in the DNA, resulting in a 60° bend. Upon binding to its operator, TtgV undergoes large conformational changes at the monomeric, dimeric, and tetrameric levels. The structures here reveal a general model for cooperative DNA binding of tetrameric gene regulators and provide a structural basis for a large body of biochemical data and a reinterpretation of previous models for tetrameric gene regulators derived from partial structural data.
H-β Zeolite: an Efficient, Reusable Catalyst for One-Pot Synthesis of Isatins from Anilines. (2010)

We describe a simple and highly efficient procedure for the single-step preparation of isatins from the commercially available anilines using H-β zeolite as a truly heterogeneous catalyst. H-β zeolite is readily separated from reaction mixture by simple filtration and reused several times without considerable loss of activity.
Response of Surface Horizons in an Oak Forest to Prescribed Burning (2000)

The reduction of forest floor ground cover and litter layers by prescribed fires may alter the morphology (field and micro) and physical properties of surface horizons. This study determined long‐term (35 yr) changes in surface horizon bulk density, organic matter concentration and content, and morphology in response to periodic (5 yr) and annual (1 yr) prescribed fires. Soils were fine‐silty, siliceous, thermic Glossic Fragiuldults, supporting mixed oak vegetation in middle Tennessee. Upper mineral soils (0‐ to 2‐cm and 0‐ to 7.6‐cm depths) were sampled and detailed field descriptions made. Periodic and control plots had a thin layer of Oi, Oe, and Oa horizons 5 yr after the 1993 burn, whereas on annual burn plots a 1‐ to 2‐cm charred layer was present. Significant reductions in organic matter concentration and mean thickness of the A horizon were found from burning (A horizons thicknesses were 6.4, 4.6, and 2.9 cm in control, periodic, and annual plots, respectively). Periodic burns did not significantly alter the organic matter and bulk density of the upper 7.6 cm of mineral soil; however, annual burns did result in significantly higher bulk densities (1.01, 1.07, and 1.29 Mg m −3 in control, periodic, and annual plots, respectively) and lower organic matter concentrations and contents. Microscopic investigations confirmed that compaction was increased from annual burning. Thin sections also revealed that the granular structure of the A horizons in control and periodic plots resulted from bioterbation of macro and mesofauna, fungi, and roots. Long‐term annual burning greatly affected surface soil properties, whereas periodic burning on a 5‐yr cycle had only limited effects.
ChemInform Abstract: Chemical and Enzymatic Triggering of 1,2‐Dioxetanes. Part 2. Fluoride‐ Induced Chemiluminescence from tert‐Butyldimethylsilyloxy‐Substituted Dioxetanes. (1987)

Abstract Photooxygenation of the adamantylidene derivatives (I) produces the 1,2‐dioxetanes (II).
A human breast cell model of pre-invasive to invasive transition (2008)

A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal characteristics, with invasive cells exhibiting features of higher grade tumors. To find functionally significant changes in transition from pre-invasive to invasive phenotype, we performed attribute profile clustering analysis on the list of genes differentially expressed between pre-invasive and invasive cells. We found integral membrane proteins, transcription factors, kinases, transport molecules, and chemokines to be highly represented. In addition, expression of matrix metalloproteinases MMP-9,-13,-15,-17 was up regulated in the invasive cells. Using siRNA based approaches, we found these MMPs to be required for the invasive phenotype. This model provides a new tool for dissection of mechanisms by which pre-invasive breast cells could acquire invasiveness in a metaplastic context.
Performance Analysis of Bit-Interleaved Space-Time (BI-ST) Coded Systems Over Wireless Channels (2006)

In this paper a union bound on the bit error probability of bit-interleaved space-time (BI-ST) coded systems is derived. The derivation is based on the uniform interleaving assumption of the coded sequence prior to transmission over the multiple antennas. The performance of a BI-ST coded system is a function of how the bit errors are distributed over the signals in the codeword. In this paper, we derive this distribution as well as the corresponding pairwise error probability. The bound is a function of the distance spectrum of the code, the signal constellation used and the space-time (ST) encoding scheme. The bound is derived for a general BI-ST coded system and applied to two specific examples; namely, the BI space-time coded modulation (BI-STCM) and the BI space-time block codes (BI-STBC). Results show that the analysis provides a close approximation to the performance for a wide range of signal-to-noise ratios (SNR).
Surface acoustic wave sensing of VOCs in harsh chemical environments (1993)

The measurement of VOC concentrations in harsh chemical and physical environments is a formidable task. A surface acoustic wave (SAW) sensor has been designed for this purpose and its construction and testing are described in this paper. Included is a detailed description of the design elements specific to operation in 300{degree}C steam and HCl environments including temperature control, gas handling, and signal processing component descriptions. In addition, laboratory temperature stability was studied and a minimum detection limit was defined for operation in industrial environments. Finally, a description of field tests performed on steam reforming equipment at Synthetica Technologies Inc. of Richmond, CA is given including a report on destruction efficiency of CCl{sub 4} in the Synthetica moving bed evaporator. Design improvements based on the field tests are proposed.
Resorbable bioactive ceramic for treatment of bone infection (2010)

Polymethylmethacrylate (PMMA) beads have been widely used in the treatment of bone infection over the last three decades. Although PMMA does offer a mechanism to quickly and effectively administer a localized dose of antibiotic to the site of infection, its efficacy is limited by its nonresorbability and nonbioactivity. Resorbable bioactive silica-calcium phosphate nanocomposite (SCPC75) was investigated as a novel controlled release carrier of vancomycin for the treatment of osteomyelitis. SCPC75 particles adsorbed significantly higher amount of vancomycin compared with PMMA. Moreover, SCPC75 provided a sustained release kinetics of therapeutic dose of vancomycin up to 35 days. The novel resorbable ceramic was able to release 95.5% of the adsorbed drug in an average dose of 12 microg/mL/day over 480 h (35 days). In conjunction with the sustained drug release, a controlled dissolution rate that led to 40% mass loss of SCPC75 was observed. On the other hand, PMMA provided a sustained release of a therapeutic dose of vancomycin for 14 days after which minimal concentration of the drug was detected. Moreover, PMMA retained 32% of the drug adsorbed onto its surface. The SCPC-vancomycin implant can serve a dual function: provide a sustained therapeutic dose of antibiotic to eradicate infection and stimulate bone cell differentiation and new bone formation. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.
Abstract 5031: A humanized mouse model for translational assessment of targeted immune checkpoint blockade (2015)

Abstract The blockade of immune checkpoints is a promising therapeutic avenue for cancer therapy, with durable objective responses observed in patients with a variety of solid tumors. Despite these successes, current animal models do not reliably identify targets with the greatest clinical potential, due in part to differences between human and murine immune systems. Hence, robust preclinical tools to test these drugs directly against human cancers in the context of a human immune system are required. Champions Oncology has now developed the ImmunoGraft, whereby two innovative technologies, the patient-derived xenograft and humanized mice (immunodeficient mice reconstituted with a human immune system), are combined in a single platform. Immune-compromised NOG (PrkdcscidIl2rgtm1Sug) mice were reconstituted (humanized) with human CD34+ cells and twelve weeks after humanization, mature human CD45+ cells comprised close to 50% of the leukocytes detected in the circulation and secondary lymphoid tissues of the now humanized animals. Growth of NSCLC tumors implanted into humanized NOG animals was comparable to those in non-humanized counterparts, and when humanized animals harboring NSCLC tumor implants were treated with ipilimumab, tumor growth was slowed, exhibiting marked regression. Systemic immune activation was observed in humanized mice following treatment with ipilimumab, characterized by robust proliferation of huCD3+ T cells and activated huCD4+ Th1 cells, as well as an increase in tumor-infiltrating huCD8+ cytotoxic T lymphocytes (all relative to vehicle controls). We have developed an innovative new preclinical cancer model, the ImmunoGraft, which will enable novel immunotherapeutic agents to be accurately evaluated for efficacy against virtually any cancer indication that can be engrafted. As a proof-of-concept of the utility of the ImmunoGraft, we demonstrated how effectively ipilimumab restricted the growth of NSCLC implants engrafted in humanized animals. This translational platform is, therefore, more reflective of the human tumor microenvironment (both immune and non-immune cell-based) and is the most clinically-relevant model for screening immune system-targeting therapies, as single agents or in combination with standard-of-care drugs and other immuno-modulators. The ImmunoGraft has strong potential to revolutionize the application of immunotherapy to both personalized oncology and translational drug discovery. Citation Format: Gilson Baia, David Vasquez-Dunddel, Daniel Ciznadija, David Sidransky, Amanda Katz, Keren Paz. A humanized mouse model for translational assessment of targeted immune checkpoint blockade. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5031. doi:10.1158/1538-7445.AM2015-5031
CW backward second harmonic generation with 720 nm-period domains in a QPM adhered-ridge waveguide (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Shimizu, T. Utsugida, S. Horikawa, K. Fujii, S. Kurimura, and H. Nakajima, "CW backward second harmonic generation with 720 nm-period domains in a QPM adhered-ridge waveguide," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper STu3H.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Real-time recognition of activity using temporal templates (2002)

A new view based approach to the representation and recognition of action is presented. The basis of the representation is a motion history image (MHI)-a static image where intensity is a function of the recency of motion in a sequence. We develop a recognition method which uses both binary and scalar valued versions of the MHI as temporal templates to match against stored instances of actions. The method automatically performs temporal segmentation, as invariant to linear changes in speed, and runs in real time on a standard platform. The applications we have begun to develop include simple room monitoring and an interactive game.