gebhart/patrepeval huggingface dataset:
Correction to Earth-Abundant Heterogeneous Water Oxidation Catalysts (2016)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Earth-Abundant Heterogeneous Water Oxidation CatalystsBryan M. Hunter, Harry B. Gray*, and Astrid M. Muller*View Author Information Beckman Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, M/C 139-74, Pasadena, California 91125, United StatesCite this: Chem. Rev. 2016, 116, 23, 14919Publication Date (Web):November 30, 2016Publication History Published online30 November 2016Published inissue 14 December 2016https://pubs.acs.org/doi/10.1021/acs.chemrev.6b00788https://doi.org/10.1021/acs.chemrev.6b00788correctionACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2623Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (430 KB) Get e-Alertsclose Get e-Alerts
The Number of Frames on ECG-Gated 18F-FDG Small Animal PET Has a Significant Impact on LV Systolic and Diastolic Functional Parameters (2021)

Using ECG-gated PET in rats, measurements of cardiac function are significantly affected by the frames per cardiac cycle. Therefore, if you are going to compare those functional parameters, a consistent number of frames should be used.
Stereoselective Synthesis of (2E,4Z)‐Dienamides Employing (Triphenylphosphoranylidene)ketene (2009)

Abstract The three‐component reaction between ylide Ph 3 PCCO, amines and aldehydes is known to afford selectively ( E )‐α,β‐unsaturated amides. We applied a variant of this methodology to the preparation of (2 E ,4 Z )‐dienamides 11 utilizing the phosphonium salt formation from ethyl 5‐aminopentanoate hydrochloride and Ph 3 PCCO followed by deprotonation with DBU and a Wittig olefination of the corresponding ylide with various ( Z )‐α,β‐unsaturated aldehydes 10 . The (2 E ,4 Z )‐dienamides 11 were isolated in yields of up to 80 %. The ( Z )‐configuration of the starting aldehydes 10 remained untouched during the reaction.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
Photomicro-Stereographs as an Aid in Interpreting Textures and Structures (1954)

ABSTRACT Photomicro-stereographs are advanced to show their usefulness in the interpretation of textures and structures. These stereograms were made with a binocular microscope and the practicability of the method is stressed.
Evaluation of filtration leucocytapheresis for use in the treatment of patients with rheumatoid arthritis (2000)

Our results suggest that filtration LCP to remove leucocytes from the peripheral blood exerts an immunomodulatory effect in patients with RA.
Dilate or debulk? (1994)

In this first in a new series of informal dialogues on controversial and emerging topics in cardiac diagnosis and therapy, two internationally known investigators tally the relative merits of atherectomy and angioplasty for percutaneous therapy of coronary artery disease.
Radio-frequency spectra of Feshbach molecules in quasi-two-dimensional geometries (2012)

The line shape of radio-frequency spectra of tightly bound Feshbach molecules in strong transverse confinement can be described by a simple analytic formula that includes final-state interactions. By direct comparison to experimental data, we clarify the role of effective-range corrections to two-body bound-state energies in lower dimensions.
Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT) (2013)

Abstract HIT is an antibody-mediated disorder characterized by thrombocytopenia and thrombosis. Activation of platelet via FcγRIIA by HIT antibodies complexed to surface-bound platelet factor 4 (PF4) contributes to the prothrombotic state. However, using an in vitro microfluidic whole human blood model of HIT, we have found through depletion and repletion studies that activation of monocytes through Syk-kinase is a key step in generating a prothrombotic milieu. Here we define the Fcγ receptor(s) upstream of Syk that mediate the thrombotic signal in monocytes. Monocytes isolated from normal healthy volunteers were incubated with 50 µg/ml of blocking antibodies against FcγRIIA (CD32, clone IV.3) and/or against FcγRI (CD64, clone 10.1) or against FcγRIII (CD16, clone 3G8), washed to remove unbound antibody and added to monocyte depleted-whole blood. These monocyte-repleted samples were then stimulated with PF4 (10 µg/ml) and the HIT like monoclonal antibody KKO (50 µg/ml) for 30 min. After recalcification (5 mmol CaCl2), samples were perfused over a von Willebrand factor-coated BioFlux microfluidic channel at a shear stress of 20 dyne/cm2 at 37°C for 15 min. Platelet adhesion was quantified by fluorescence microscopy after adding Calcein-AM (3 µM), and fibrin was visualized by adding Alexa 561-labeled fibrinogen (1.5 μg/ml) to the whole blood prior to the perfusion. Selective inhibition of FcγRIIA on monocytes led to an ∼40% inhibition of fibrin deposition and comparable reduction in the formation of “coated” platelets relative to samples repleted with non-inhibited monocytes. Flow cytometry studies showed that these observations were not due to leaching of IV.3 antibody off the monocytes with subsequent blocking of platelet FcγRIIA. In contrast, selective blockade of FcγRI or FcγRIII in depletion/repletion studies or in whole blood did not significantly reduce platelet adhesion, formation of coated platelets, or fibrin accumulation. However, blocking FcγRI did decrease tissue factor (TF) activity on monocytes stimulated with PF4 and KKO and this effect was additive to FcγRIIA inhibition. In summary, our data show that monocyte-bound HIT IgG antibodies contribute to the prothrombotic state by activating FcγRIIA directly and indirectly by generating TF though FcγRI. We speculate that this activation of monocytes contributes to platelet activation and monocyte microparticle formation demonstrated previously. Drugs that target FcγRI and FcγRIIA on monocytes may help prevent thrombosis in HIT without causing platelet dysfunction or increasing the risk of bleeding. Disclosures: No relevant conflicts of interest to declare.
Low Salinity Flooding (LSF) in Sandstones at Pore Scale: Micro-Model Development and Investigation (2016)

Abstract Low salinity waterflooding (LSF) is receiving increased interest as a promising method to improve oil recovery efficiency. Most of the literature agrees that on the Darcy scale, LSF can be regarded as a wettability modification process leading to a more water-wet state, although no general consensus on the microscopic mechanisms has been reached. While wettability alteration may be a valid causal mechanism also on the pore scale, it is currently unclear how oil that detaches from mineral surfaces within individual pores connects to an oil bank or finds its way to a producer. In order to establish a link between the pore scale and the Darcy scale description, the flow dynamic at the scale of (networks of) multiple pores should be investigated. One of the main challenges in addressing phenomena on this intermediate "pore network" scale is to design a model system representative for natural rock. The model system should allow for a systematic investigation of influencing parameters with pore-scale resolution whilst simultaneously being large enough to capture larger length scale effects like saturation changes and the mobilization and connection of oil ganglia. In this paper, we use micro-models functionalized with active clay minerals as model system to study the low salinity effect (LSE) on the pore scale. A new method was devised to deposit clays in the micro-model. Clay suspensions were made by mixing natural clays (Montmorillonite) with isopropyl alcohol (IPA) and injected into optically transparent 2D glass micro-models. By drying the micro-model, the clay particles are deposited and stick naturally to the glass surfaces and remain attached even under flow of high salinity (HS) and low salinity (LS) brines. In a parametric study the dependence of the LSE on the type of oil (crude oil versus n-decane), the presence of clay particles and ageing was investigated. Our results show that the system is responsive to LS brine as the effective contact angle of crude oil shifts towards a more water-wetting state when brine salinity is reduced. When using n-decane as a reference case of inert oil, no change in contact angle occurred after a reduction in brine salinity. This responsiveness in terms of contact angle does not necessarily mean that more oil is recovered. Only in the cases where the contact angle change (due to low salinity exposure) led to release of oil and re-connection with oil of adjacent pore bodies, the oil became mobile and oil saturation was effectively reduced. This makes contact angle changes a necessary but not sufficient requirement for incremental recovery by LSF. Interestingly, the wettability modification was observed in absence of clay. Osmosis and IFT were found to be not the primary driving mechanisms of the low salinity response.
High-Power 1.48-$\mu$m Wafer-Fused Optically Pumped Semiconductor Disk Laser (2011)

An output power up to 5 W at 1.48-μm wavelength is achieved from an optically pumped semiconductor disk laser. An active region composed of an AlGaInAs/InP heterostructure grown on an InP substrate was wafer fused with an AlGaAs/GaAs Bragg reflector grown on a GaAs substrate. An intracavity diamond heatspreader bonded to the gain structure surface provides efficient heat removal from the active element. The results further validate that the wafer fusion technique offers a flexible platform for high-power disk lasers in a wide wavelength range.
A model for a library‐management toolbox (2012)

Purpose Quality management, and its associated evidence‐based ideology, have influenced library management from at least the beginning of the 1990s. Both concepts emphasize that decisions have to be based on facts. Libraries have a long history of using statistics in data collection due to international agreements and standards. Although there is much data available in the libraries, perhaps this collected data have not been utilized as effectively as possible. This paper aims to discuss the possibilities of combining different types of statistical data in order to measure the efficiency of the work being done in libraries and what possible impact they can have in their parent organizations. It also aims to use the concept of data warehousing as a tool for joining different types of statistical data in the analysis. Design/methodology/approach This paper is a case study with statistical analysis of library data collected and a conceptual analysis of possibilities in the data warehousing of the library and library‐related data in order to improve its analysis. Findings The authors suggest that in order to improve the analysis of the library statistical data towards the actual effects the library has, for example, to the learning and research done within university, one must start to develop statistical data systems that enable the combination of different types of statistical data. This needs co‐operation between different vendors and government officials in defining the statistical data collected. Research limitations/implications The paper is based on Finnish experiences and the data warehousing model should be tested empirically and developed further due to the challenges in the conformity of the data collected. Practical implications The paper presents ideas and possibilities to evolve the library statistical data analysis. Social implications The paper presents ideas for national and international bodies in how to develop statistical data systems and their interoperability. Originality/value The paper promotes the idea of combining library and other statistical data collected in order to provide better tools for library management.
Flame Retardant Epoxy Resins (2004)

As part of a program to develop fire resistant exterior composite structures for future subsonic commercial aircraft, flame retardant epoxy resins are under investigation. Epoxies and their curing agents (aromatic diamines) containing phosphorus were synthesized and used to prepare epoxy formulations. Phosphorus was incorporated within the backbone of the epoxy resin and not used as an additive. The resulting cured epoxies were characterized by thermogravimetric analysis, propane torch test, elemental analysis and microscale combustion calorimetry. Several formulations showed excellent flame retardation with phosphorous contents as low as 1.5 % by weight. The fracture toughness of plaques of several cured formulations was determined on single-edge notched bend specimens. The chemistry and properties of these new epoxy formulations are discussed.
Abstract 823: Anti-melanoma effects of novel Cripto-1 CFC small peptide mimetics (2018)

Abstract The diagnosis of melanoma is increasing and current therapies for advanced disease remain unsuccessful. Thus, research aimed at developing novel targeting approaches is needed. Cripto-1 (CR-1), an epidermal growth factor (EGF)-like developmental morphogen, functions as a co-receptor for the tumor growth factor (TGF)-beta related molecule, Nodal. CR-1/Nodal signaling pathways can induce cell survival, proliferation and migration of cancer cells. Studies have shown that Nodal is expressed at high levels in advanced melanoma. CR-1 has also been shown to be expressed in melanoma but limited to a small subpopulation of melanoma cells with more stem cell-like characteristics. Recent work has demonstrated that targeting Nodal in melanoma is associated with reduction of a significant population of melanoma cells. However, a residual population continues to persist. We hypothesize that interference with CR-1/Nodal receptor binding dynamics will negatively affect downstream Nodal-dependent signaling events important for cancer growth and further reduce the number of surviving melanoma cells. To test this hypothesis, we have developed small peptides that mimic CR-1 CFC binding domain and prevent CR-1 from binding to the ALK4 receptor necessary for proper CR-1 co-receptor function for Nodal. We show that in vitro treatment of human melanoma cells with our prototype CFC mimetic B3 reduced melanoma cell viability and negatively affected melanoma cell cycle progression. We also show that treatment with B3 resulted in reduction of active Smad2/3 and ERK1/2, known to be involved in downstream Nodal signaling, as a result of B3 interference with CR-1 co-receptor function. These preliminary data provide the scientific rationale for the development of anti-CR-1 and Nodal therapeutics that can synergize with or complement current treatment approaches in melanoma. Citation Format: Emanuela Iaccarino, Gustavo Untiveros, Annamaria Sandomenico, Andrea Caporale, Luisa Calvanese, Lucia Falcigno, Gabriella D'Auria, Menotti Ruvo, Luigi Strizzi. Anti-melanoma effects of novel Cripto-1 CFC small peptide mimetics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 823.
Project orientation in the organic laboratory (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProject orientation in the organic laboratoryDouglas C. Neckers Cite this: J. Chem. Educ. 1970, 47, 10, 700Publication Date (Print):October 1, 1970Publication History Received3 August 2009Published online1 October 1970Published inissue 1 October 1970https://doi.org/10.1021/ed047p700RIGHTS & PERMISSIONSArticle Views115Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts
Sequential two-photon (730-800-nm) excitation of Nd 3+ :SrF 2 (1990)

Sequential two-photon absorption has been recently observed when pumping Nd3+:YAG at ≈ 740 nm.1 In this work, Nd3+:SrF2 is excited with a pulsed (150-μs).
A multiscale method for data assimilation (2019)

In data assimilation problems, various types of data are naturally linked to different spatial resolutions (e.g., seismic and electromagnetic data), and these scales are usually not coincident to the subsurface simulation model scale. Alternatives like upscaling/downscaling of the data and/or the simulation model can be used, but with potential loss of important information. Such alternatives introduce additional uncertainties which are not in the nature of the problem description, but the result of the post processing of the data or the geo-model. To address this issue, a novel multiscale (MS) data assimilation method is introduced. The overall idea of the method is to keep uncertain parameters and observed data at their original representation scale, avoiding upscaling/downscaling of any quantity. The method relies on a recently developed mathematical framework to compute adjoint gradients via a MS strategy in an algebraic framework. The fine-scale uncertain parameters are directly updated and the MS grid is constructed in a resolution that meets the observed data resolution. This formulation therefore enables a consistent assimilation of data represented at a coarser scale than the simulation model. The misfit objective function is constructed to keep the MS nature of the problem. The regularization term is represented at the simulation model (fine) scale, whereas the data misfit term is represented at the observed data (coarse) scale. The computational aspects of the method are investigated in a simple synthetic model, including an elaborate uncertainty quantification step, and compared to upscaling/downscaling strategies. The experiment shows that the MS strategy provides several potential advantages compared to more traditional scale conciliation strategies: (1) expensive operations are only performed at the coarse scale; (2) the matched uncertain parameter distribution is closer to the “truth”; (3) faster convergence behavior occurs due to faster gradient computation; and (4) better uncertainty quantification results are obtained. The proof-of-concept example considered in this paper sheds new lights on how one can reduce uncertainty within fine-scale geo-model parameters with coarse-scale data, without the necessity of upscaling/downscaling the data nor the geo-model. The developments demonstrate how to consistently formulate such a gradient-based MS data assimilation strategy in an algebraic framework which allows for implementation in available computational platforms.
Trimeric, cyclic Ti10-containing 27-tungsto-3-germanate [(α-Ti3GeW9O37OH)3(TiO3(OH2)3)]17− (2011)

The trimeric, cyclic polyanion [( α -Ti 3 GeW 9 O 37 OH) 3 (TiO 3 (OH 2 ) 3 )] 17− ( Ti 10 ) was synthesized by reaction of [ A-α- GeW 9 O 34 ] 10− with K 8 [Ti 4 O 4 (C 2 O 4 ) 8 ] in a mixture of rubidium and lithium acetate buffers at 60 °C, and then crystallized as a mixed rubidium-potassium-sodium salt, Rb 13 K 2 Na 2 [( α -Ti 3 GeW 9 O 37 OH) 3 (TiO 3 (OH 2 ) 3 )]·40H 2 O ( Rb-Ti 10 ). The title compound was characterized in the solid state by IR, single-crystal XRD, TGA and elemental analysis, and in solution by 183 W-NMR. In order to prepare a pure sample of Rb-Ti 10 , several reaction parameters need to be carefully controlled, such as the ratio of rubidium and lithium acetate buffers, the choice of titanium precursor (K 8 [Ti 4 O 4 (C 2 O 4 ) 8 ]), the reaction temperature, and very importantly, the concentration of rubidium ions.
The poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888 potentiates the antitumor activity of temozolomide in the B16F10 syngeneic melanoma model: Correlation with pharmacokinetic levels and a reduction in poly(ADP-ribose) polymer by ELISA. (2007)

4946 Poly(ADP-ribose) polymerase (PARP) is essential in recognizing DNA-damage and facilitating DNA repair. This is consistent with the observation that PARP-1/-2 knockout mice have increased sensitivity to DNA damaging agents including radiation. Therefore, inhibition of PARP should enhance the efficacy of chemotherapeutic agents by increasing the extent of DNA damage. ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor (K i 2-2.5 nM). ABT-888 has been shown to potentiate the activity of DNA damaging agents in a variety of preclinical models. The ability of ABT-888 to enhance the antitumor efficacy of temozolomide (TMZ) was evaluated in the current study. ABT-888 showed significant potentiation of TMZ in vivo in a dose-responsive manner with no observed toxicity. In the B16F10 model, TMZ as a single agent demonstrated significant efficacy (%TGI= 60-80), however, when TMZ and ABT-888 were administered in combination, significant improvement over TMZ alone was obtained (%TGI=75-93). As expected, ABT-888 did not show single agent activity in this model or other xenograft models evaluated. Various schedules of ABT-888 (administered prior to TMZ or overlaying several days prior to and/or after TMZ) showed no advantage in increasing potentiation compared to co-administration with TMZ. Pharmacokinetic levels (plasma and tumor) of ABT-888 correlated with antitumor efficacy. Moreover, in mice treated with ABT-888 at timepoints corresponding to the C max of ABT-888, intratumor drug levels also correlated with the significant poly(ADP-ribose)/PAR polymer inhibition in a dose-proportional/time-dependent manner as determined by ELISA. Overall, our studies demonstrated that the potentiation of TMZ activity by ABT-888 correlated with the plasma and tumor drug levels, as well as inhibition of a pharmacodynamic marker, PAR polymer, in this preclinical model. ABT-888 is currently being evaluated in clinical trials (CTEP/NCI) utilizing a PAR ELISA to assess the reduction in PAR/PARP activity in patients.
Transcriptomic-based analysis of the Lactobacillus plantarum WCFS1 response to oleuropein (2017)

Póster presentado a la VII International Conference on Environmental Industrial and Applied Microbiology, celebrada en Madrid (España) del 18 al 20 de octubre de 2017.
Using Downstream DPSK Signal for Upstream OOK Signal Remodulation with RSOA in Hybrid WDM-TDM Passive Optical Networks (2009)

We propose a signal remodulation of DPSK downstream and OOK upstream signals using RSOA at the customer side for the hybrid WDM-TDM PONs. Error-free operation was achieved in a 20-km-reach WDM-TDM PONs without dispersion compensation.