gebhart/patrepeval huggingface dataset:
L1 FePt-ZrO2 (001) nanostructured films with high aspect ratio columnar grains (2014)

In order to increase the signal-to-noise ratio of heat assisted magnetic recording, it is desirable to fabricate high magnetic anisotropy FePt media with small grain size and high aspect ratio (grain height to size ratio). In the present paper, we report that FePt media with small grain size and high aspect ratio were achieved by doping ZrO2 into FePt film grown on TiON intermediate layer. The grain size was around 5.6 nm, and the aspect ratio was as high as 2.6. It is believed that this originated from the ZrO2 (002) tetragonal crystalline phase epitaxially grown on TiON intermediate layer. With a 5 vol. % carbon doping into FePt-ZrO2 films, the perpendicular anisotropy was improved and the out-of-plane coercivity was around 23.2 kOe. Doping of crystalline phase material with certain required crystal structure may offer a method for fabrication of nanostructured thin films with high aspect ratio grains at high processing temperature.
Synthesis and Duplex‐Stabilizing Properties of Fluorinated N‐Methanocarbathymidine Analogues Locked in the C3′‐endo Conformation (2014)

The efficient synthesis, antiviral activity, and duplex-stabilizing properties of both isomers of the 2'-fluoro analogue of Northern methanocarbathymidine (N-MCT), 2 and 3, are reported. We show that 2'-F incorporation on the N-MCT scaffold has a strong stabilizing effect on duplex thermal stability.
Dopant Enhanced Diffusion for High n-type Doped Ge (2013)

We study the phosphorous (P) diffusion in Ge grown on Si substrate with different background doping and we find that the diffusion coefficient is extrinsic and is enhanced by over 500 times in Ge doped at 1x10 19 cm -3 compared to diffusivity in intrinsic Ge. We study the loss mechanisms in Ge-on-Si. We show that the doping level is a result of the balance between in-diffusion and dopant loss. The high diffusivity in doped Ge leads to a uniform distribution of P in Ge with the concentration above 4.5x10 19 cm -3 .
DR with a DSLR: digital radiography with a digital single-lens reflex camera (2010)

An inexpensive, portable digital radiography (DR) detector system for use in remote regions has been built and evaluated. The system utilizes a large-format digital single-lens reflex (DSLR) camera to capture the image from a standard fluorescent screen. The large sensor area allows relatively small demagnification factors and hence minimizes the light loss. The system has been used for initial phantom tests in urban hospitals and Himalayan clinics in Nepal, and it has been evaluated in the laboratory at the University of Arizona by additional phantom studies. Typical phantom images are presented in this paper, and a simplified discussion of the detective quantum efficiency of the detector is given.
Top-emitting organic light-emitting diodes: Influence of cavity design (2010)

We report on red top-emitting organic light-emitting diode structures with higher order cavities. The emission zone is placed in the first, second, and third antinodes of the electric field in the cavity by increasing the hole transport layer thickness. Furthermore, the thicknesses of the cathode and the capping layer are varied to achieve high efficiencies. Using doped charge transport layers and a phosphorescent emitter, we reach up to 29%, 17%, and 12% external quantum efficiencies for first, second, and third order devices, respectively. An optical model is further used to analyze the angular dependent emission.
How can nanomedicines overcome cellular-based anticancer drug resistance? (2016)

Despite the great progress in the field of cancer research, complete remission of cancer patients is a rarely seen outcome in clinics. The failure of a plethora of promising anticancer drugs is mostly due to the insurgence of multidrug resistance (MDR) phenomena with various factors, both physio-pathological and cellular, being responsible for their development. Over the past 40 years, the impressive progress in the nanotechnology field and its application in medicine (i.e., nanomedicine) enabled the development of novel cancer treatments with improved specificity and efficacy, mainly referring to the possibility to overcome MDR. However, the emergence of many nanomedicines defined in the literature as "overcoming the resistance" has resulted in very few of them eventually being approved for clinical application and reaching the marketplace (liposomal formulation of doxorubicin (Myocet®, Caelix®) and paclitaxel nanoparticles (Abraxane®), for instance). The capacity of nanomedicines to overcome physio-pathological-based resistance by enhancing drug accumulation at the tumor site via passive and ligand-mediated targeting has been largely reviewed in the past few years. This review will specifically focus on the cellular mechanisms involved in the MDR, which will be discussed with respect to the cellular site in which their action is exerted (that is, membrane, cytoplasm or nucleus). A complete overview of various nanomedicines designed to bypass or directly inhibit each of these specific resistance mechanisms will be offered.
ChemInform Abstract: Effects of Dopants on Performance of Metal Crystallites. Part 2. Further Characterization of Doped Supports and Catalysts. (1988)

Abstract Measurements of the specific electrical conductivity and activation energy of electron conduction performed for TiO 2 doped with Mg 2+ , Ge 4+ , Ta 5+ , Sb 5+ , or W 6+ clearly demonstrate that the Fermi energy level of the parent TiO 2 support is altered by altervalent ion doping.
The 10,000 Instruments Workshop - (Im)practical Research for Critical Speculation (2022)

This paper describes the 10,000 Instruments workshop, a collaborative online event conceived to generate interface ideas and speculate on music technology through open-ended artefacts and playful design explorations. We first present the activity, setting its research and artistic scope. We then report on a selection of outcomes created by workshop attendees, and examine the critical design statements they convey. The paper concludes with reflections on the make-believe, whimsical and troublemaking approach to instrument design adopted in the workshop. In particular, we consider the ways this activity can support individuals' creativity, unlock shared musical visions and reveal unconventional perspectives on music technology development.
Development of Process Technologies for High-Performance MOS-Based SiC Power Switching Devices (2007)

Abstract : In this work we developed the technology for 20 kV insulated gate bipolar transistors (IGBTs) in 4H-SiC. The p-channel IGBT is formed on a 175-micron p-type epilayer on an n+ substrate. The n-IGBT is formed on the C-face of a 200-micron n-type free-standing epilayer. When operated at 300 W/cm2, the p- and n-IGBTs carry 30 and 27 A/cm2 respectively, independent of temperature from 23 deg C to 175 deg C. These results were made possible by advances in epigrowth of thick SiC epilayers with low doping, high carrier lifetime, and minimal basal plane dislocations. Ambipolar lifetimes as high as 1.7 microns and BPD densities as low as 2.6 cm-2 were achieved. The work was further supported by research on the MOS interface on both C-face and Si-face SiC, including studies of threshold voltage and long-term reliability. Oxides on the C-face have comparable mobility to those on the Si-face, but lower breakdown fields and reduced long-term reliability.
Fishing for carbon nanotubes with a plasmonic metamaterial net (2013)

It has recently been shown that a strong light-driven near-field force is generated between an illuminated plasmonic metamaterial and a dielectric or metallic surface [1]. We experimentally demonstrate that plasmonic metamaterial efficiently collects carbon nanotubes (CNTs) when the metamaterial is illuminated with laser light through the fibre.
Rhodium(I)-catalyzed hydrogenation of olefins. The documentation of hydroxyl-directed stereochemical control in cyclic and acyclic systems (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRhodium(I)-catalyzed hydrogenation of olefins. The documentation of hydroxyl-directed stereochemical control in cyclic and acyclic systemsDavid A. Evans and Michael M. MorrisseyCite this: J. Am. Chem. Soc. 1984, 106, 13, 3866–3868Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00325a030https://doi.org/10.1021/ja00325a030research-articleACS PublicationsRequest reuse permissionsArticle Views2568Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Phase I study of OGX-011, a second generation antisense oligonucleotide (ASO) to clusterin, combined with cisplatin and gemcitabine as first-line treatment for patients with stage IIB/IV non-small cell lung cancer (NSCLC) (2006)

17078 Background: The clusterin gene is frequently expressed in NSCLC and encodes a cytoprotective chaperone protein that promotes cell survival and is upregulated in response to apoptotic stimuli such as chemotherapy. OGX-011 is an ASO that binds to clusterin mRNA thus potently regulating expression and chemosensitizing cancer cells. Previous Phase I studies of OGX-011 identified biologically active doses of 480mg to 640mg. The objective of this multi-center Phase I study was to define the Phase 2 dose of OGX-011 in combination with standard chemotherapy. Methods: Patients (pts) with chemotherapy-naive advanced stage IIIB/IV NSCLC were potentially eligible. OGX-011 is given as a 2hr IV infusion weekly after 3 loading doses (days -7, -5, and -3). OGX-011 dose escalation was planned to a maximum of 640mg. Cisplatin was given at 75 mg/m 2 IV day 1 and gemcitabine 1250mg/m 2 IV days 1 and 8, on a 21-day schedule up to 6 cycles. Pharmacokinetic profiling was done in cycle 1. Results: Between Jan 2004 and Apr 2005, 10 patients were enrolled. Median age 62 yrs (49–75); 4 female. ECOG 0/1: 3/7. Stage IIIB/IV: 1/9. 9 of 10 pts completed at least one cycle; 1 withdrew after one dose of OGX-011 due to progressive disease (PD). Of the 9 pts, 6 received ≥ 5 cycles and 3 received 2–4 cycles (2 patients discontinued due to PD and 1 at the pts request). Median follow-up: 5.0m (1.6 - 6.7m). As of Jan 2006, 2 pts had a PR; 5 had SD; 2 had PD. 4 pts had 5 serious adverse events: elevated creatinine, hypoxia, pneumonia, pleural effusion, and febrile neutropenia. 3 pts had Gr 3 hyponatremia. Gr 3/4 hematological toxicities in 10–40% and 10–20%, respectively. No dose-limiting toxicities noted; 7 pts received OGX-011 at 640 mg. A proportional increase in OGX-011exposure (C max and AUC 0-inf ) from 480 to the 640 mg was noted with no apparent effect on GEM/CIS. Conclusions: OGX-011 was well tolerated and can be given at biologically active doses (640 mg) with standard GEM/CIS chemotherapy for patients with advanced NSCLC. A multicenter Phase II trial of this combination is underway. Sponsored by OncoGenex Technologies, Inc. with Isis Pharmaceuticals Inc. [Table: see text]
Chromosome-Based Proteomic Study for Identifying Novel Protein Variants from Human Hippocampal Tissue Using Customized neXtProt and GENCODE Databases (2015)

The goal of the Chromosome-Centric Human Proteome Project (C-HPP) is to fully provide proteomic information from each human chromosome, including novel proteoforms, such as novel protein-coding variants expressed from noncoding genomic regions, alternative splicing variants (ASVs), and single amino acid variants (SAAVs). In the 144 LC/MS/MS raw files from human hippocampal tissues of control, epilepsy, and Alzheimer's disease, we identified the novel proteoforms with a workflow including integrated proteomic pipeline using three different search engines, MASCOT, SEQUEST, and MS-GF+. With a <1% false discovery rate (FDR) at the protein level, the 11 detected peptides mapped to four translated long noncoding RNA variants against the customized databases of GENCODE lncRNA, which also mapped to coding-proteins at different chromosomal sites. We also identified four novel ASVs against the customized databases of GENCODE transcript. The target peptides from the variants were validated by tandem MS fragmentation pattern from their corresponding synthetic peptides. Additionally, a total of 128 SAAVs paired with their wild-type peptides were identified with FDR <1% at the peptide level using a customized database from neXtProt including nonsynonymous single nucleotide polymorphism (nsSNP) information. Among these results, several novel variants related in neuro-degenerative disease were identified using the workflow that could be applicable to C-HPP studies. All raw files used in this study were deposited in ProteomeXchange (PXD000395).
Learning-Based Extended Object Tracking Using Hierarchical Truncation Measurement Model With Automotive Radar (2021)

This paper presents a data-driven measurement model for extended object tracking (EOT) with automotive radar. Specifically, the spatial distribution of automotive radar measurements is modeled as a hierarchical truncated Gaussian (HTG) with structural geometry parameters that can be learned from the training data. The HTG measurement model provides an adequate resemblance to the spatial distribution of real-world automotive radar measurements. Moreover, large-scale radar datasets can be leveraged to learn the geometry-related model parameters and offload the computationally demanding model parameter estimation from the state update step. The learned HTG measurement model is further incorporated into a random matrix based EOT approach with two (multi-sensor) measurement updates: one is based on a factorized Gaussian inverse-Wishart density representation and the other is based on a Rao-Blackwellized particle density representation. The effectiveness of the proposed approaches is verified on both synthetic data and real-world nuScenes dataset over 300 trajectories.
GPS Integrity and Potential Impact on Aviation Safety (2003)

This paper assesses the capability of GPS to provide the level of safety required for different aircraft flight navigation operations. It presents an analysis of the protection offered against potential catastrophic GPS failures at system and user levels. This is followed by an assessment of the different approaches to augmenting GPS for civil air navigation. Results show the inadequacy of GPS as a system for real-time safety critical use.
Controlled release of bisphosphonate from a biodegradable implant: Evaluation of release kinetics and anticalcification effect (1992)

Abstract The present investigation describes the formulation and the in vivo efficacy of prolonged controlled‐release chitosan matrices, containing the novel anticalcification agents adipoyland suberoylbisphosphonate (AdBP and SuBP). Chitosan matrices were prepared by the solvent‐cast method and the role of several factors such as polymer molecular weight (MW), crosslinking, and drug load concentration, on the release rate profile have been examined. Crosslinking of chitosan films retarded degradation rate of the polymer but not the release rate of the embedded drug. Chitosan's MW and drug load concentration did not affect drug release rate. The release kinetics of the bisacylphosphonates were characterized by initial burst‐effect and pseudo zero‐order kinetics in the following release phase. AdBP/chitosan matrices (co‐implanted subdermally in rats with the calcifiable bioprosthetic heart valve tissue) significantly inhibited tissue calcification after 15 and 30 days implantation (66.4 and 108.6 μg/mg Ca ++ in comparison to 2.7 and 3.6 μg/mg Ca ++ , untreated and treated groups, respectively). No side effects were noted.
Transmit Diversity Scheme over Single SC-FDM Symbol for LTE-Advanced (2009)

In 3GPP LTE-Advanced, open-loop transmit diversity schemes for the uplink are of great interest. It seems that, space-frequency block code (SFBC), the diversity scheme already adopted in the downlink of LTE Release-8, would be a natural option. However, when applying SFBC directly to the uplink, the resulting waveform at one transmit antenna becomes multi-carrier like with higher peak to average power ratio (PAPR), which limits the power efficiency of the corresponding power amplifier (PA). Another option will be to apply conventional space-time block code (STBC) scheme over two consecutive single-carrier frequency-division multiplexing (SCFDM) symbols. But in some cases, one uplink slot contains an odd number of data SC-FDM symbols, then the last data symbol in the slot will become an orphan symbol over which the conventional STBC will not work. Hence, we want to find a transmission scheme that operates on a single SC-FDM symbol and is able to achieve similar diversity performance as SFBC. Meanwhile, we would like to preserve single-carrier waveform at both transmit antennas to maximize the PA efficiency. To meet this end, we propose a novel transmission scheme: "One Symbol STBC" that operates on a single SC-FDM symbol and can achieve full transmit diversity. Meanwhile, the single-carrier waveform requirement is fulfilled at both transmit antennas. In addition to theoretical justifications, link-level simulations are also carried out which proves our proposed "One Symbol STBC" indeed achieves similar diversity performance as SFBC while maintaining single-carrier waveform's low PAPR.
Health-Related Quality of Life (HRQL) in Patients with Advanced Cutaneous Squamous Cell Carcinoma (CSCC) Treated with Cemiplimab: Post Hoc Exploratory Analysis of a Phase 2 Clinical Trial (2020)

Abstract not available.
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes (2016)

Human genomes are routinely compared against a universal reference. However, this strategy could miss population-specific and personal genomic variations, which may be detected more efficiently using an ethnically relevant or personal reference. Here we report a hybrid assembly of a Korean reference genome (KOREF) for constructing personal and ethnic references by combining sequencing and mapping methods. We also build its consensus variome reference, providing information on millions of variants from 40 additional ethnically homogeneous genomes from the Korean Personal Genome Project. We find that the ethnically relevant consensus reference can be beneficial for efficient variant detection. Systematic comparison of human assemblies shows the importance of assembly quality, suggesting the necessity of new technologies to comprehensively map ethnic and personal genomic structure variations. In the era of large-scale population genome projects, the leveraging of ethnicity-specific genome assemblies as well as the human reference genome will accelerate mapping all human genome diversity.
Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer (2020)

DNA methylation-based biomarkers in plasma and urine could be useful as an adjunct to CT screening to guide decision-making regarding further invasive procedures in patients with pulmonary nodules.
NIR-Sensitized Photopolymerization with Iodonium Salts Bearing Weak Coordinating Anions (2016)

Photoinitiated Polymerization of TPGDA was initiated with a NIR LED emitting at 790 nm using a redox based photoinitiator system comprising a cyanine as photosensitizer and a diaryl iodonium salt. The latter bears different anions exhibiting low coordination behavior; that is [B(Ph)4]-, [B(PhF5)4]-, [B(Ph(CF3)2)4]-, [B(Ph-4-Cl)4]-, [(CF3SO2)2N]-, PF6-, and [PF3(C2F5)3]-. Photo-DSC was applied to determine photopolymerization activity. This correlated with the conductivity with many of these anions showing that reactivity mostly correlates with ion mobility. Nevertheless, iodonium salts bearing as anions either [PF3(C2F5)3]-, [B(Ph(CF3)2)4]- or [(CF3SO2)2N]- exhibit an excellent solubility being larger than several 100 g L-1. Furthermore, NIR sensitized cationic photopolymerization of aziridines was successfully demonstrated.
A Longitudinal Study of Stargardt Disease: Quantitative Assessment of Fundus Autofluorescence, Progression, and Genotype Correlations (2013)

The AF pattern at baseline influences the enlargement of atrophy over time and has genetic correlates. These data are likely to assist in the provision of counseling on prognosis in Stargardt disease and be valuable for future clinical trials.
ChemInform Abstract: Total Synthesis of 11‐Deoxyanthracyclines: 4‐Demethoxy‐11‐deoxydaunomycin, 11‐Deoxydaunomycin, and Their Analogues. (1989)

Abstract The naphthoquinones (I) undergo cyclocondensation with the tetrahydrohomophthalic anhydride (II) in the presence of a base to give the tetrahydronaphthacenediones (III).
Intent-based Networking for Connectivity and Cloud Services (2021)

Recent developments in networking and services technologies increased number of choices for users and complexity of networks and services. At the same time, there is substantial effort in the industry to enhance user experiences with services. The enhancement of user experiences is tightly coupled with mapping of user intents to services by shielding customers from the complexity and automating management processes involved in ordering and delivering services. The mapping is an iterative process. Its accuracy is expected to be improved as Service Providers gain experience with the process. Automating management processes in a management infrastructure with non-virtualized OSSs (Operating Support Systems) is lengthy and difficult. Virtualization and artificial intelligence/machine learning (AI/ML) techniques accelerate the automation greatly. The automation improves not only user experiences with services, but also the management of networks and applications by network administrators. This paper will describe user intents, a method for mapping user intents to connectivity and cloud services, and the design process, with examples. The concepts and methods described here are expected to be used by consumers and administrators of networks and applications forming services. The intents and their mappings can be expanded for each service by adding unique capabilities and attributes for connectivity and application options of a given service.
Electrically controllable polarization-dependent phase grating from photocurable liquid crystals (2004)

Electrically controllable Raman–Nath phase diffraction grating has been fabricated in a very simple way using photopolymerizable liquid crystals. The efficiency of the first-order diffraction peak has been measured with the variation of the polarization angle of the incident light as well as with the variation of an applied electric field. Dynamic response and the relaxation dynamics of the first-order peak were measured by applying a dc electric field on and off, respectively, and were found to be very fast.