gebhart/patrepeval huggingface dataset:
Neuro-Physiologically-Driven Adaptive Automation to Improve Decision Making Under Stress (2006)

The advent of netted communications and a wide array of battlefield sensors is enabling real-time information streaming and asset management. However, the burden of information management is placed solely on the receiver of the information. Honeywell Laboratories developed a Communications Scheduler (CoS), an adaptive information management system for the dismounted Soldier, driven by an assessment of the individual's current cognitive capacity to process incoming information, in order to improve decision making under high task load conditions. An evaluation was conducted to demonstrate whether cognitive capacity to perform under differing task loads could be detected using neuro-physiological sensors and then if the adaptive automation would appropriately regulate information flow. Results revealed an improvement in primary task performance, no degradation in concurrent secondary tasks, and lower subjective workload ratings while performing cognitively challenging working memory tasks with the CoS, although a slight loss in situation awareness of lower priority message was found. The appropriate allocation of cognitive resources is key to managing multiple tasks, focusing on the most important ones, and maintaining overall situation awareness.
Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy (2011)

Tumor immunotherapy with IL-18 can significantly augment the killing fraction of phase-specific chemotherapeutic drugs and provide survival benefit. The safety profile of IL-18 and its positive interactions with select anticancer chemotherapeutic agents strongly supports the clinical investigation of this combinatorial approach.
Asymmetric Library Synthesis of P-Chiral t-Butyl-Substituted Secondary and Tertiary Phosphine Oxides (2019)

An asymmetric synthesis, amenable to library preparation of structurally diverse P-chiral t-butyl substituted secondary phosphine oxides (SPOs) and tertiary phosphine oxides (TPOs), was developed. A P-chiral H-phosphinate building block was prepared via a two-step, one-pot condensation of a chiral auxiliary with t-BuPCl<sub>2</sub>, followed by hydrolysis. Nucleophilic displacement of the chiral auxiliary with Grignard reagents, followed by hydrolysis, provided a library of P-chiral SPOs. In situ treatment of the prehydrolysis intermediate with electrophiles also provided a library of P-chiral TPOs in high enantiomeric purity.
Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation (2016)

Cytosine methylation, predominantly of the CpG sequence in vertebrates, is one of the major epigenetic modifications crucially involved in the control of gene expression. Due to the difficulty of reconstituting site‐specifically methylated nucleosomal DNA at crystallization quality, most structural analyses of CpG methylation have been performed using chemically synthesized oligonucleotides, There has been just one recent study of nucleosome core particles (NCPs) reconstituted with nonpalindromic human satellite 2‐derived DNAs. Through the preparation of a 146‐bp palindromic α‐satellite‐based nucleosomal DNA containing four CpG dinucleotide sequences and its enzymatic methylation and restriction, we reconstituted a ‘symmetric’ human CpG‐methylated nucleosome core particle (NCP). We solved the crystal structures of the CpG‐methylated and unmodified NCPs at 2.6 and 3.0 A resolution, respectively. We observed the electron densities of two methyl groups, among the eight 5‐methylcytosines introduced in the CpG‐fully methylated NCP. There were no obvious structural differences between the CpG‐methylated ‘symmetric NCP’ and the unmodified NCP. The preparation of a crystallization‐grade CpG‐methylated NCP provides a platform for the analysis of CpG‐methyl reader and eraser proteins.
Supplementary figures 1-7 from Customized Viral Immunotherapy for HPV-Associated Cancer (2023)

&lt;p&gt;S1: RT-PCR confirms expression of E6 and E7 in TC1 S2: CD4+ T cell responses after E6E7 vaccination S3: E6E7 vaccination induces T-cell degranulation Tumor free S4: Tumor volume curves in E6E7 vaccinated mice S5: TCM frequency in mice after TC1 tumor clearance S6: PCA analysis of TC1 tumors S7: Images of MG1-GFP infected HPV+ primary tumor&lt;/p&gt;
Multiple jet production at low transverse energies inpp¯collisions ats=1.8TeV (2003)

We present data on multiple production of jets with transverse energies near 20 GeV in $p\overline{p}$ collisions at $\sqrt{s}=1.8\mathrm{TeV}.$ QCD calculations in the parton-shower approximation of PYTHIA and HERWIG and the next-to-leading order approximation of JETRAD are compared to the data for one, two, three, and four jet inclusive production. Transverse energy spectra and multiple jet angular and summed transverse-energy distributions are adequately described by the shower approximation while next-to-leading order calculations describe the data poorly.
Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion (2012)

Both the function of HB-EGF as an EGFR ligand and a novel signal for HB-EGF-C nuclear translocation induce gastric cancer growth, whereas HB-EGF-C nuclear translocation independently plays a critical role in gastric cancer invasion. The present study demonstrated that HB-EGF-C nuclear translocation might be crucial in gastric cancer invasion. HB-EGF-C nuclear translocation may offer a prognostic marker and a new molecular target for gastric cancer therapy.
P135-T Structural Characterization of a Recombinant Monoclonal Antibody by Electrospray Ion-Mobility Time-of-Flight Mass Spectrometry (2007)

Recombinant monoclonal antibodies (MAb) comprise a significant proportion of biopharmaceuticals used in diagnostic and therapeutic applications. Although the general structural features of monoclonal antibody such as disulfide bond patterns have been known for decades, the intrinsic heterogeneity of such molecules has imposed the needs for thorough analytical characterizations so the structural details of each pharmaceutical MAb are determined, and safe, effective, and reproducible products can be generated. The analysis of intact MAb molecules is challenging due to their high molecular mass, hydrophobic nature, and presence of sugar moieties. Conversely, the analysis of intact protein is also advantageous because it reduces dramatically the time for sample preparation and data interpretation compared with peptide mapping and sequencing. Furthermore, it also minimizes the chance of introducing putative modifications, which are often observed during peptide mapping. The aim of this study is to perform structural characterization of a recombinant monoclonal antibody (IgG1) by a newly developed electrospray ion-mobility time-of-flight mass spectrometer (ESI-IM-TOF MS) using a top-down approach. In this approach, the molecular masses of the intact and the deglycosylated antibodies as well as the light and heavy chains of the antibody were measured by direct infusion to MS. The mass difference between intact and the deglycosylated antibody establishes the glycosylation profile of the antibody. For the reduced antibody, the ligh and heavy chains are separated in the gas phase by the ion mobility functionality of the instrument. Thus, the masses of light and heavy chains are accurately measured to yield further evidence for other post-translational modifications. Furthermore, the fragmentation of the intact light chain subunit and subsequent separation of fragment ions by ion mobility allows us to quickly obtain partial sequence of the light chain. All of the results demonstrate that ESI-IM-TOF-MS is a superior tool to characterize MAbs and other complex protein pharmaceuticals.
Constant Analysis of Local Stability of a Real Modulus Algorithm Adaptive Filter (1988)

Abstracf-The constant modulus algorithm (CMA) for adaptive filtering was developed for usage when the modulus of the desired signal is known, but its specific value at every sample instant is not known. A real arithmetic version of CMA was recently proposed and studied via simulations by Treichler and Larimore. This paper proves local stability of their real arithmetic version of CMA in two applications: i) channel equalization for a transmitted sequence of plus and minus ones, and ii) the separation of a sinusoidal signal from its sum with a number of sinusoidal interferers at separate frequencies. The proofs utilize dynamic system stability theorems from averaging theory, which is a technique currently being exploited in the stability analysis of a variety of adaptive systems.
A three-dimensional virtual community based on space-sharing architecture (1998)

This paper describes a new architecture that aims to realize small and flexible virtual communities on the World Wide Web by using three-dimensional graphics and chat systems. It introduces a concept of generating, managing, and lapsing of communities linked to URLs. We present a basic architecture that is based on a client–server model, a space-managing technique using fixed size regions, a pack-delivery technique for message propagation, and a space-sharing technique using a server named Interactive VRML server. Finally, we review the results of our experimental service “CyberCity96.” © 1998 Scripta Technica, Syst Comp Jpn, 29(14): 11–20, 1998
Lifetime-Extending 3-(4-Phenylbenzo[4,5]thieno[3,2-d]pyrimidin-2-yl)benzonitrile Acceptor for Thermally Activated Delayed Fluorescence Emitters (2021)

Highly efficient and long-living green thermally activated delayed fluorescence (TADF) organic light-emitting diodes (OLEDs) were developed using benzothienopyrimidine-4-benzonitrile acceptor-derived compounds as the TADF emitters. A molecular design merging the benzothienopyrimidine-4-benzonitrile acceptor with either indolocarbazole or diindolocarbazole was employed to prepare two TADF emitters, 5-(2-phenylbenzo[4,5]thieno[3,2-<i>d</i>]pyrimidin-4-yl)-2-(5-phenylindolo[3,2-<i>a</i>]carbazol-12(5<i>H</i>)-yl)benzonitrile and 2-(10,15-diphenyl-10,15-dihydro-5<i>H</i>-diindolo[3,2-<i>a</i>:3',2'-<i>c</i>]carbazol-5-yl)-5-(2-phenylbenzo[4,5]thieno[3,2-<i>d</i>]pyrimidin-4-yl)benzonitrile (BTPDIDCz), as the green and greenish-yellow emitters. Among the two emitters, BTPDIDCz with the diindolocarbazole donor combined with the benzothienopyrimidine-4-benzonitrile acceptor demonstrated a high external quantum efficiency of 24.5% and 3 times longer device lifetime than the state-of-the-art green emitter. This work proposed the potential of benzothienopyrimidine-4-benzonitrile as the acceptor for long lifetime in TADF emitters.
British Gas/Lurgi Slagging Gasifier a springboard into synfuels (1981)

The most developed and widely used fixed bed pressure gasification systems are based on the Lurgi Gasification Process. The British Gas/Lurgi Slagging Gasifier results from the joing together of British Gas Corporation and Lurgi Company technology. The British Gas Slagging Gasification technology offers significant advantages over dry bottom Lurgi and other fixed bed gasification systems. The slagging gasifier has more advantages than disadvantages when compared with entrained flow gasifiers and these advantages are sufficient to give it an economic advnatage in most process situations. The processing of crude Slagging Gasifier gas and the multifarious uses of the resulting clean gas in the chemicals, power generation and fuel gas fields are described. The environmental impact of the process is also discussed and plans for commercialization are considered. 21 refs.
35.4: Enhancement of Emission Efficiency in White OLED Device by Highly Efficient Narrow Spectrum Red‐Emission Material (2014)

Abstract Newly developed red‐emission material with a narrow spectrum enhanced the current efficiency of a red OLED 1.3 times greater than a conventional material while maintaining chromaticity of red. This material also increased the power efficiency of a white OLED 1.2 times greater than the conventional material without impairing color rendering.
Essentials to Develop Data-Driven Predictive Models of Prognostics and Health Management for Distributed Electrical Systems (2019)

The reliability of the electrical networks significantly impacts customer as well as energy providers' bottom line. Connectivity between the various sectors of the electrical network has been expressively increased due to the high penetration of the new smart hardware and software tools. Therefore, Prognostics and Health Management (PHM) becoming a critical factor in the efficiency of capital-intensive corporations especially for the energy sector including the electrical power generation. Degradation based analysis is one of the valuable approaches of condition-based algorithms in order to obtain the reliability information especially for the highly reliable systems, critical assets, and recently developed products. The main purpose of the degradation-based models is to predict the future condition of the asset and perform the maintenance in an optimized time window before the actual failure of the system. Failure is said to have occurred as a soft failure event in these types of models. The main purpose of this study is to study the essentials in developing the first hitting time degradation-based models to predict the critical time for initiating the maintenance actions in order to optimize the effectiveness of the PHM leading to enhancing the value of the assets for the distributed electrical systems. The analyses are mostly focused on the critical components of the distributed electrical systems. The latest generations of the degradation models are exploring the potential improvements based on the more available information provided by smart devices to predict the critical failure time. Robust predictive models are beneficial to both energy providers and customers to enhance the overall reliability and risk of the system by initiating the maintenance before the physical failure occurs. In this paper, General Path (GP) and Autoregressive (AR) models as general methodologies for degradation models would be discussed in detail based on the depth of the analyses and available information.
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. (2020)

Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral conversion from adrenal dehydroepiandrosterone (DHEA) to potent androgens and has a germline missense-encoding polymorphism. The adrenal restrictive HSD3B1(1245A) allele limits conversion, whereas the adrenal permissive HSD3B1(1245C) allele increases DHEA metabolism to potent androgens. In the Severe Asthma Research Program (SARP) III cohort, we determined the association between DHEA-sulfate and percentage predicted forced expiratory volume in 1 s (FEV1PP). HSD3B1(1245) genotypes were assessed, and association between adrenal restrictive and adrenal permissive alleles and FEV1PP in patients with (GC) and without (noGC) daily oral glucocorticoid treatment was determined (n = 318). Validation was performed in a second cohort (SARP I&amp;amp;II; n = 184). DHEA-sulfate is associated with FEV1PP and is suppressed with GC treatment. GC patients homozygous for the adrenal restrictive genotype have lower FEV1PP compared with noGC patients (54.3% vs. 75.1%; P &amp;lt; 0.001). In patients with the homozygous adrenal permissive genotype, there was no FEV1PP difference in GC vs. noGC patients (73.4% vs. 78.9%; P = 0.39). Results were independently confirmed: FEV1PP for homozygous adrenal restrictive genotype in GC vs. noGC is 49.8 vs. 63.4 (P &amp;lt; 0.001), and for homozygous adrenal permissive genotype, it is 66.7 vs. 67.7 (P = 0.92). The adrenal restrictive HSD3B1(1245) genotype is associated with GC resistance. This effect appears to be driven by GC suppression of 3β-HSD1 substrate. Our results suggest opportunities for prediction of GC resistance and pharmacologic intervention.
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation (2020)

Sperm-associated antigen 5 (SPAG5) is an important driver of the cell mitotic spindle required for chromosome segregation and progression into anaphase. SPAG5 has been identified as an important proliferation marker and chemotherapy-sensitivity predictor, especially in estrogen receptor-negative breast cancer subtypes. Here, we report that SPAG5 is a direct target of miR-10b-3p, and its aberrantly high expression associates with poor disease-free survival in two large cohorts of breast cancer patients. SPAG5 depletion strongly impaired cancer cell cycle progression, proliferation, and migration. Interestingly, high expression of SPAG5 pairs with a YAP/TAZ-activated signature in breast cancer patients. Reassuringly, the depletion of YAP, TAZ, and TEAD strongly reduced SPAG5 expression and diminished its oncogenic effects. YAP, TAZ coactivators, and TEAD transcription factors are key components of the Hippo signaling pathway involved in tumor initiation, progression, and metastasis. Furthermore, we report that SPAG5 is a direct transcriptional target of TEAD/YAP/TAZ, and pharmacological targeting of YAP and TAZ severely reduces SPAG5 expression. Collectively, our data uncover an oncogenic feedback loop, comprising miR-10b-3p, SPAG5, and YAP/TAZ/TEAD, which fuels the aberrant proliferation of breast cancer.
ChemInform Abstract: CHEMIE DER ENAMINE 11. MITT. RK. ALPHA,BETA‐UNGESAETTIGTER SAEUREN UND SAEURECHLORIDE MIT IMINEN, SYNTH. VON 2‐OXO‐TETRAHYDROPYRIDINEN UND 2‐OXO‐OKTAHYDROCHINOLINEN (1971)

Abstract Unter verschiedenen Reaktionsbedingungen setzen sich cyclische Imine wie z.B. (Ia) mit Acryloylchlorid (II) zu einem Gemisch der Enamide (IIIa) und (IVa) und des Chinolons (Va) um; (Ib) liefert mit (II) kein Enamid (III), sondern (IVb) und (Vb) neben N‐Cyclohexyl‐acrylamid.
Nonlinear optical characterisation of CdS and PbS quantum dots dispersed in a glass matrix (2004)

We report on the third- order nonlinear optical properties of sol-gel prepared CdS quantum dots (with different thermal treatments, filling factors and matrix), and commercial Schott filters (CdSSe nanodots), compared to a bulk CdS crystal. Also PbS quantum dots have been characterised. The spectral dispersion of third-order nonlinear optical response of the samples has been determined by third harmonic generation (THG). By taking into account the dots concentration and appropriate local field correction factor, we have been able to extrapolate a renormalised nonlinear coefficient for the dots, which can be directly compared to the nonlinear coefficient of the forming bulk constituents. In the out-of-resonance regime, no intrinsic enhancement of the nonlinear coefficient due to quantum confinement has been detected for any sample, with respect to the bulk constituent. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
6-qubit Optimal Clifford Circuits (2020)

Clifford group lies at the core of quantum computation -- it underlies quantum error correction, its elements can be used to perform magic state distillation and they form randomized benchmarking protocols, Clifford group is used to study quantum entanglement, and more. The ability to utilize Clifford group elements in practice relies heavily on the efficiency of their circuit-level implementation. Finding short circuits is a hard problem; despite Clifford group being finite, its size grows quickly with the number of qubits $n$, limiting known optimal implementations to $n{=}4$ qubits. For $n{=}6$, the number of Clifford group elements is about $2.1{\cdot}10^{23}$. In this paper, we report a set of algorithms, along with their C/C++ implementation, that implicitly synthesize optimal circuits for all 6-qubit Clifford group elements by storing a subset of the latter in a database of size 2.1TB (1KB=1024B). We demonstrate how to extract arbitrary optimal 6-qubit Clifford circuit in $0.0009358$ and $0.0006274$ seconds using consumer- and enterprise-grade computers (hardware) respectively, while relying on this database.
ChemInform Abstract: Total Synthesis of the Macrolide Antibiotic Cytovaricin. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Accelerated Subspace Tracking Scheme and Its Applications to Multiuser Systems (2006)

This paper is concerned with a new subspace tracking method by using an accelerated RLS algorithm for time-varying parameters, and its application to direction-of-arrival (DOA) estimation and blind multiuser detection (MUD) in the case that the spatial information of users rapidly changes. The proposed subspace tracker is derived by combining the projection approximation subspace tracking (PAST) with the internal model principle, approximately expressing the changing parameters with an expansion of polynomial time functions. It can still maintain the linear computational complexity to the number of users, similar to the PAST. The effectiveness is validated through some numerical simulations of DOA estimation in a narrowband source scenario and blind MUD in a synchronous DS-CDMA system, respectively
Toward a theory for scheduling dags in Internet-based computing (2006)

Conceptual and algorithmic tools are developed as a foundation for a theory of scheduling complex computation-dags for Internet-based computing. The goal of the schedules produced is to render tasks eligible for allocation to remote clients (hence, for execution) at the maximum possible rate. This allows one to utilize remote clients well, as well as to lessen the likelihood of the "gridlock" that ensues when a computation stalls for lack of eligible tasks. Earlier work has introduced a formalism for studying this optimization problem and has identified optimal schedules for several significant families of structurally uniform dags. The current paper extends this work via a methodology for devising optimal schedules for a much broader class of complex dags, which are obtained via composition from a prespecified collection of simple building-block dags. The paper provides a suite of algorithms that decompose a given dag /spl Gscr/ to expose its building blocks and an execution-priority relation /spl utri/ on building blocks. When the building blocks are appropriately interrelated under /spl utri/ the algorithms specify an optimal schedule for /spl Gscr/.
Saturation effects in a continuous-wave HF chemical laser (1985)

The multiline performance of a cw HF chemical laser was measured as a function of the SF6 and H2 flow rates, cavity losses, pressure and resonator type. The first data from a cw laser for a near-resonant energy transfer from v = 3, /=3,4 to v = 2, /=14 with a subsequent rotational cascade to v = 2, /=11 were obtained. The stable resonator data indicated that the polarization introduced by the Brewster windows affects the power spectral distribution. The amplitude, frequency, and Fresnel number dependence of the time-dependent oscillations which were predicted to occur on lines whose saturated gain does not fill the unstable resonator were measured. The data showed that the oscillations do not occur for Fresnel numbers below 1.5 and that their amplitudes increase as the fraction of the resonator filled by the oscillating lines decreased. The a priori prediction of these characteristics of the time-dependent oscillations by the MNORO3UR computer model was in agreement with the data.