gebhart/patrepeval huggingface dataset:
Multiple metal-carbon bonds. 30. Rhenium(VII) neopentylidene and neopentylidyne complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 30. Rhenium(VII) neopentylidene and neopentylidyne complexesD. Scott Edwards and Richard R. SchrockCite this: J. Am. Chem. Soc. 1982, 104, 24, 6806–6808Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00388a067https://doi.org/10.1021/ja00388a067research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chlorination of a Zeolitic-Imidazolate Framework Tunes Packing and van der Waals Interaction of Carbon Dioxide for Optimized Adsorptive Separation (2021)

Molecular separation of carbon dioxide (CO<sub>2</sub>) and methane (CH<sub>4</sub>) is of growing interest for biogas upgrading, carbon capture and utilization, methane synthesis and for purification of natural gas. Here, we report a new zeolitic-imidazolate framework (ZIF), coined COK-17, with exceptionally high affinity for the adsorption of CO<sub>2</sub> by London dispersion forces, mediated by chlorine substituents of the imidazolate linkers. COK-17 is a new type of flexible zeolitic-imidazolate framework Zn(4,5-dichloroimidazolate)<sub>2</sub> with the SOD framework topology. Below 200 K it displays a metastable closed-pore phase next to its stable open-pore phase. At temperatures above 200 K, COK-17 always adopts its open-pore structure, providing unique adsorption sites for selective CO<sub>2</sub> adsorption and packing through van der Waals interactions with the chlorine groups, lining the walls of the micropores. Localization of the adsorbed CO<sub>2</sub> molecules by Rietveld refinement of X-ray diffraction data and periodic density functional theory calculations revealed the presence and nature of different adsorption sites. In agreement with experimental data, grand canonical Monte Carlo simulations of adsorption isotherms of CO<sub>2</sub> and CH<sub>4</sub> in COK-17 confirmed the role of the chlorine functions of the linkers and demonstrated the superiority of COK-17 compared to other adsorbents such as ZIF-8 and ZIF-71.
An expressive and compact representation of musical sound (2004)

We describe a representation of musical instrument sounds in which the sound is codified as the time histories of the parameters controlling a nonlinear physical model of the target musical instrument. As opposed to source-filter models often employed in speech, in which an assumed periodic source is filtered by a time varying acoustic transfer function, in our proposed method the nonlinear dynamical behavior of the source generator in interaction with an acoustic filter is directly simulated. The resulting autonomous oscillations of the combined system are controlled by a small number of slowly varying parameters. This representation has two advantages; first, it is extremely compact, requiring only 10's of bytes/sec of data, and second, it naturally captures variations of musical timbre and other nuances of live musical performance. We present preliminary results for recorded clarinet sounds in which the maximum likelihood estimation (MLE) method is used to infer the control parameter histories for an assumed target clarinet model.
PageNet: Page Boundary Extraction in Historical Handwritten Documents (2017)

When digitizing a document into an image, it is common to include a surrounding border region to visually indicate that the entire document is present in the image. However, this border should be removed prior to automated processing. In this work, we present a deep learning based system, PageNet, which identifies the main page region in an image in order to segment content from both textual and non-textual border noise. In PageNet, a Fully Convolutional Network obtains a pixel-wise segmentation which is post-processed into the output quadrilateral region. We evaluate PageNet on 4 collections of historical handwritten documents and obtain over 94% mean intersection over union on all datasets and approach human performance on 2 of these collections. Additionally, we show that PageNet can segment documents that are overlayed on top of other documents.
Sustainable synthesis of zwitterionic galactaric acid monoamides as monomers of hydroxylated polyamides (2022)

A new and sustainable preparation of zwitterionic monoamides of galactaric acid is reported. The protocol consists of an efficient conversion of aldaric acid into the corresponding lactone and its further reaction in the presence of diamines, leading to the formation of the corresponding zwitterionic monoamides in high yields and selectivity. The zwitterions have been used as monomers to obtain the corresponding polyhydroxyamides. The overall protocol has shown a high atom economy, and all the carbon atoms present in the reagents are preserved.
Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation (2019)

Abstract Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation on the cell surface, which is the primary function of endocytic protein complexes. The mechanism through which membrane curvature is imposed during formation of clathrin-coated vesicles is an ongoing controversy. Using super-resolved live cell fluorescence imaging, we demonstrate that curvature generation by clathrin-coated pits can be detected in real time within cultured cells and tissues of developing metazoan organisms. We found that the footprint of clathrin coats increase monotonically during formation of curved pits at different levels of plasma membrane tension. Our findings are only compatible with models that predict curvature generation at early stages of endocytic clathrin-coated pit formation. Therefore, clathrin-coated vesicle formation does not necessitate a dynamically unstable clathrin lattice that would allow an abrupt flat-to-curved transition. Summary Endocytic clathrin coats acquire curvature without a flat-to-curved transition that requires an extensive reorganization of the clathrin lattice.
Abstract 2377: Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma (2018)

Abstract Multiple myeloma (MM) is one of the most common hematological malignancies, but current therapeutic options are limited to high-dose chemotherapy or high-risk stem-cell transplantation. In a kinome-wide RNAi study by Tiedemann and colleagues (2010), the G-protein coupled receptor kinase GRK6 was identified as a critical kinase required for survival of MM cells. This study also suggests that MM cells, but not other cell types, are dependent on GRK6; and that gene silencing by shRNA or siRNA of GRK6, but not other members of the GRK family, results in decreased survival. Through gene silencing techniques, we determined that a functional GRK6 kinase domain is required for survival of MM cells. These findings helped validate that the kinase domain of GRK6 is a promising target for MM, and therefore encouraged us to embark on an effort to identify potent small molecule kinase inhibitors of GRK6. Toward that end, by screening a focused kinase-directed library of small molecule inhibitors, compounds with moderate potency against GRK6 in biochemical assays were identified. Through this exercise, we discovered that two structurally distinct aminopyrazoles AZ-960 and ASC-082 had modest inhibition of GRK6. By combining structural features of these hits and further optimization we identified the quinazoline analogue OICR9945, a potent GRK6 inhibitor with good selectivity against a panel of diverse kinases and anti-proliferative activity against MM cell lines. Herein, we describe the design, synthesis and early pharmacological characterization of OICR9945 along with structure activity relationships (SAR) of this series against GRK6 and other kinases. Citation Format: David Uehling, Babu Joseph, Carly Griffin, Ratheesh Subramaniam, Ayome Abibi, Richard Marcellus, Michael Prakesch, Gennadiy Poda, Methvin Isaac, Chungyee Leung-Hagesteijn, Rodger Tiedemann, Rima Al-awar. Design, synthesis, and characterization of 4-aminopyrazole quinazolines as potent inhibitors of G protein-coupled receptor kinase GRK6 for the potential treatment of multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2377.
HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC (2009)

The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early immune responses, could represent adaptation for rapid growth in a newly infected host, or could represent reversion from less fit forms of the virus that were selected for immune escape in previous hosts. Here we investigated the diversification of HIV-1 env coding sequences in 81 very early B subtype infections previously shown to have resulted from transmission or expansion of single viruses (n = 78) or two closely related viruses (n = 3). In these cases, the sequence of the infecting virus can be estimated accurately, enabling inference of both the direction of substitutions as well as distinction between insertion and deletion events. By integrating information across multiple acutely infected hosts, we find evidence of adaptive evolution of HIV-1 env and identify a subset of codon sites that diversified more rapidly than can be explained by a model of neutral evolution. Of 24 such rapidly diversifying sites, 14 were either i) clustered and embedded in CTL epitopes that were verified experimentally or predicted based on the individual's HLA or ii) in a nucleotide context indicative of APOBEC-mediated G-to-A substitutions, despite having excluded heavily hypermutated sequences prior to the analysis. In several cases, a rapidly evolving site was embedded both in an APOBEC motif and in a CTL epitope, suggesting that APOBEC may facilitate early immune escape. Ten rapidly diversifying sites could not be explained by CTL escape or APOBEC hypermutation, including the most frequently mutated site, in the fusion peptide of gp41. We also examined the distribution, extent, and sequence context of insertions and deletions, and we provide evidence that the length variation seen in hypervariable loop regions of the envelope glycoprotein is a consequence of selection and not of mutational hotspots. Our results provide a detailed view of the process of diversification of HIV-1 following transmission, highlighting the role of CTL escape and hypermutation in shaping viral evolution during the establishment of new infections.
Characterization of Multiple-Optical-Axis Implementation of Pattern-Integrated Interference Lithography (2013)

The image quality and collimation in a multiple-optical-axis Pattern-Integrated Interference Lithography (PIIL) system are evaluated for a prototype system. Image quality and collimation are individually and jointly optimized for this configuration.
FastMRI Prostate: A Publicly Available, Biparametric MRI Dataset to Advance Machine Learning for Prostate Cancer Imaging. (2023)

The fastMRI brain and knee dataset has enabled significant advances in exploring reconstruction methods for improving speed and image quality for Magnetic Resonance Imaging (MRI) via novel, clinically relevant reconstruction approaches. In this study, we describe the April 2023 expansion of the fastMRI dataset to include biparametric prostate MRI data acquired on a clinical population. The dataset consists of raw k-space and reconstructed images for T2-weighted and diffusion-weighted sequences along with slice-level labels that indicate the presence and grade of prostate cancer. As has been the case with fastMRI, increasing accessibility to raw prostate MRI data will further facilitate research in MR image reconstruction and evaluation with the larger goal of improving the utility of MRI for prostate cancer detection and evaluation. The dataset is available at https://fastmri.med.nyu.edu.
341 Quick Measurement Method of Electroosmotic Flow Velocity (2008)

Electroosmotic flow is applied to form a denaturing gradient on a microchip. Quick measurement of electroosmotic flow velocity on site is required for precise process control. Proposed method is applied to the microchannel with a Y-shaped junction. High voltage signals are applied to the two wells upstream of the junction and the downstream well is grounded. A neutral dye is added to one of the upstream wells. Under the condition of constant sum of two high voltage signals, two voltage signals are fluctuated in a square waveform with known frequency. From the image analysis of the flow with propagating cyclic disturbance of a dye, the flow velocity can be calculated easily.
Inside Intel: Sales Forecasting using an Information Aggregation Mechanism (2013)

We evaluate the performance of an information aggregation mechanism (IAM) implemented inside Intel to forecast unit sales for the company. Developed, rened and tested in the laboratory using experimental methods, the IAM is designed specically to aggregate information. Its implementation at Intel allows us to test its performance in a much more complex eld environment. The IAM provides not only a point forecast of future sales but also yields the full distribution of participants’ beliefs regarding this variable. This predictive distribution very closely matches the distribution over outcomes at short horizons while slightly underweighting low-probability realizations of unit sales at long horizons. Compared to Intel’s \ocial forecast, the IAM forecasts
Preclinical to clinical translation of anti-PD-1 blockade (2015)

Meeting abstracts Pembrolizumab (MK-3475), a humanized monoclonal IgG4 antibody against programmed death receptor 1 (PD-1), is currently being studied in clinical trials across more than 30 types of cancers. Immunotherapy with anti–PD-1 monoclonal antibodies such as pembrolizumab shows robust,
Model-based control in the pulp and paper industry (2006)

The pulp and paper industry offers a wide spectrum of research challenges to the control systems community. Implementations of control technology, production planning, scheduling, and operations can lead to tangible improvements in terms of increased capital returns and reduced environmental impact. This paper presents an overview of operations in an integrated pulp and paper mill and reviews the control challenges for important process units. It also summarizes current and future research areas in the pulp and paper industry
Mist chemical vapor deposition of aluminum oxide thin films for rear surface passivation of crystalline silicon solar cells (2014)

We show the promising potential of mist chemical vapor deposition (CVD), a nonvacuum and solution-based technology, for the growth of an AlOx film as a rear surface passivation layer of crystalline silicon (c-Si) solar cells, supported by its safety, low process cost, and low energy consumption for the growth. The AlOx layer grown at 350 °C with aluminum acetylacetonate and ozone, without a successive annealing process, showed an excellent surface passivation property with the negative fixed charge density of about (1–2) × 1012 cm−2, as highlighted by the surface recombination velocity of ∼10 cm/s.
Comparison of two angiotensin II analogues in normal subjects and hypertensive patients. (1978)

Two angiotensin II analogues, i.e., 1-sarcosine, 8-isoleucine angiotensin II (Sar1, Ile8-AII) and 1-sarcosine, 8-alanine angiotensin II (Sar1, Ala8-AII), are now available in the clinical study. Comparative studies of the antagonistic potency and the agonistic effect of these two AII analogues were made in normal subjects on three sodium balances and in hypertensive patients with various etiologies on sodium depletion. Both AII analogues had an agonistic pressor effect in normal subjects. This effect changed with different sodium balances. In the low sodium state, this agonistic action was minimized. The agonistic pressor effect of Sar1, Ile8-AII was greater than that of Sar1, Ala8-AII in all sodium states. There was found an agonistic activity of both AII analogues not only on blood pressure, but also on renin and aldosterone secretion, and renal vasculature in normal subjects on a regular diet. The antagonistic depressor potency of both compounds was also varied by changing sodium balance, being greatest in the low sodium state. In hypertensive patients on sodium depletion, the blood pressure responses of individual patients to these two AII analogues were significantly correlated (r = 0.8, n = 20). These results indicate taht pretreatment of sodium depletion is necessary to prevent the side effect caused by the agonistic pressor action of AII analogue, and also to predict renin depency in hypertensive patients efficiently.
Imaging approaches to assess mechanism-of-action and response in patients with advanced hepatocellular carcinoma treated with the novel oncolytic poxvirus JX-594. (2013)

210 Background: The novel oncolytic virus JX-595 has demonstrated anti-cancer mechanisms of action, as defined in preclinical models, which includes cytolysis, intra-tumoral vascular disruption, and immune-mediated tumor targeting. Methods: To determine whether mechanism(s) of action (MOA) of the novel anti-cancer oncolytic virus JX-594 could be demonstrated by MRI imaging in patients with advanced hepatocellular carcinoma (HCC), dynamic contrast-enhanced MRI of the liver was performed at baseline, day 5, and week 8 following intra-tumoral injection. Images were evaluated by a central reviewer blinded to treatment and dose using both modified RECIST and Choi response criteria. 17/30 subjects underwent day 5 (D5) post-treatment imaging; 28/30 had week 8 (W8) imaging. Results: Choi responses correlated more reliably than RECIST with JX-594 MOA. Evidence of intra-tumoral vascular shutdown, manifest by areas of reduced or non-enhancement (Choi response), was observed in 6 of 17 subjects on D5 5 MRI scans. Day 5 Choi responses were a predictor of week 8 Choi responses in all but 1 subject. Of the 11/17 D5 Choi non-responders, 3 were Choi responders at 8 weeks. Increase in size at D5 of small lesions present at baseline (“unmasking”) is compatible with oncolytic flare due to intra-tumoral edema contributed to by cell lysis and immune infiltration. RECIST criteria tumor measurements did not identify MOA of JX-594, and resulted in the appearance of pseudoprogression at D5 in some subjects. Conclusions: Hyperacute MRI post-therapy can be used to detect activity of the JX-594, a novel oncolytic anti-cancer therapy. Day 5 Choi responses were a predictor of subsequent response at week 8. Clinical trial information: NCT00554372.
Maximum ratio Combining performance with imperfect channel estimates (2002)

In this paper, we examine the impact of channel estimation errors on Maximum Ratio Combining (MRC) in receive diversity systems, in the presence of co-channel interferers. The channel is modelled as flat Rayleigh fading, slowly varying and spatially independent. It is assumed that the spatial combiner weights are imperfect estimates of the desired user's fading coefficients and complex Gaussian distributed. Closed form expressions for signal to interference plus noise ratio (SINR) distribution and outage probability is obtained. Using these expressions, the effect of channel estimation quality on performance is investigated.
Estimation of patient-specific material properties of the mitral valve using 4D Transesophageal Echocardiography (2013)

4D Transesophageal Echocardiography (TEE) is a newly developed tool to visualize the morphology and dynamics of the mitral valve for diagnosis and treatment planning. Quantitative patient-specific modeling of the mitral valve is demanded since it allows for the reliable predictive simulation of medical intervention. State-of-the-art image-based and biomechanical models with generic material parameters have limited predictive power as they are only partially fitted to patient-data. As a step closer to a fully personalized model, an estimation algorithm is presented in this paper. The method combines image-derived mitral valve dynamics with a biomechanical model to estimate regional patient-specific material parameters in-vivo. In particular, the extended Kalman filter (EKF) is adopted in a way that it becomes flexible to integrate any biomechanical model and more parameters of interest in the estimation. The algorithm was verified on synthetic data with known Young's modulus and shear modulus, yielding less than 5% error. The algorithm was also evaluated on 4D TEE images of five patients. Estimated Young's moduli agree with the clinical observation that material parameters vary regionally and among the population. The estimated material parameters can be used in patient-specific modeling as well as the detection and evaluation of diseased areas.
Abstract 3215: GITRL-Fc can significantly reduce tumor growth by stimulating innate and adaptive immunity (2016)

Abstract Although the interaction between GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) and GITRL (its ligand) is important for the development of immune responses, the cellular mechanisms underlying anti-tumor immunity including both innate and adaptive immunity is not fully understood. We generated a novel single-gene linkerless GITRL trimer fused to an immunoglobulin Fc domain (GITRL-Fc), and investigated its effect on controlling tumor growth and immune responses in preclinical tumor models. Treatment with GITRL-Fc significantly reduced tumor growth in several preclinical tumor models by inducing Th1 biased anti-tumor immunity and reducing Treg-mediated immune suppression. Immune cell depletion studies showed that anti-tumor immunity induced by GITRL-Fc depended on CD8+ T cells as well as NK cells. Furthermore, the combination of GITRL-Fc with PD-1 blockade significantly reduced the tumor growth in the Renca murine kidney adenocarcinoma tumor model. Taken together, these results suggest that GITRL-Fc can improve cancer treatment as a single agent or in combination therapy by enhancing innate and adaptive cellular immunity. Citation Format: Hyun-Bae Jie, Minu K. Srivastava, Erin Mayes, Rui Yun, Fumiko Axelrod, Jorge Monteon, Austin Gurney, Angie In-Kyung Park. GITRL-Fc can significantly reduce tumor growth by stimulating innate and adaptive immunity. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3215.