gebhart/patrepeval huggingface dataset:
Supplementary Figure Legend from Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of <i>PDE11A</i> Sequence Variants That Are Frequent in the Population (2023)

Supplementary Figure Legend from Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of &lt;i&gt;PDE11A&lt;/i&gt; Sequence Variants That Are Frequent in the Population
Tantalum-based Gate Electrode Metals for Advanced CMOS Applications (2006)

Abstract not Available.
Assessment of Diet-Related Changes on Albendazole Absorption, Systemic Exposure, and Pattern of Urinary Excretion in Treated Human Volunteers (2021)

Soil-transmitted-helminth (STH) infections are a persistent global public health problem. Control strategies for STH have been based on the use of mass drug administration (MDA) mainly targeting preschool- and school-aged-children, although there is increasing interest in expanding treatment to include adults and others through community-wide MDA. Coverage assessment is critical to understanding the real effectiveness of albendazole (ALB) treatment in those MDA programs. The work described here aims to (i) evaluate the effect of type of diet (a heavy or light meal) and fasting before ALB treatment on the systemic disposition of ALB and its metabolites in treated human volunteers and (ii) evaluate the potential feasibility of detecting albendazole metabolites in urine. The data reported here demonstrate that the systemic availability of the active ALB-sulfoxide (ALBSO) metabolite was enhanced more than 2-fold after food ingestion (a heavy or light meal). ALB dissolution improvement related to the ingestion of food may modify the amount of drug/metabolites reaching the parasite, affecting drug efficacy and the overall success of MDA strategies. The measurement in urine samples of the amino-ALB-sulfone (NHALBSO<sub>2</sub>) derivative and ALBSO for up to 96 h suggests that it may be feasible to develop a noninvasive tool to evaluate compliance/adherence to ALB treatment.
Localizing Unsynchronized Sensors With Unknown Sources (2023)

We propose a method for sensor array self-localization using a set of sources at unknown locations. The sources produce signals whose times of arrival are registered at the sensors. We look at the general case where neither the emission times of the sources nor the reference time frames of the receivers are known. Unlike previous work, our method directly recovers the array geometry, instead of first estimating the timing information. The key component is a new loss function which is insensitive to the unknown timings. We cast the problem as a minimization of a non-convex functional of the Euclidean distance matrix of microphones and sources subject to certain non-convex constraints. After convexification, we obtain a semidefinite relaxation which gives an approximate solution; subsequent refinement on the proposed loss via the Levenberg-Marquardt scheme gives the final locations. Our method achieves state-of-the-art performance in terms of reconstruction accuracy, speed, and the ability to work with a small number of sources and receivers. It can also handle missing measurements and exploit prior geometric and temporal knowledge, for example if either the receiver offsets or the emission times are known, or if the array contains compact subarrays with known geometry.
Finding Groups in Gene Expression Data (2005)

The vast potential of the genomic insight offered by microarray technologies has led to their widespread use since they were introduced a decade ago. Application areas include gene function discovery, disease diagnosis, and inferring regulatory networks. Microarray experiments enable large-scale, high-throughput investigations of gene activity and have thus provided the data analyst with a distinctive, high-dimensional field of study. Many questions in this field relate to finding subgroups of data profiles which are very similar. A popular type of exploratory tool for finding subgroups is cluster analysis, and many different flavors of algorithms have been used and indeed tailored for microarray data. Cluster analysis, however, implies a partitioning of the entire data set, and this does not always match the objective. Sometimes pattern discovery or bump hunting tools are more appropriate. This paper reviews these various tools for finding interesting subgroups.
Bolustriggerung und NaCl-Bolus bei der biphasischen Spiral-CT des Abdomens (1997)

Individual bolus tracking with subsequent injection of 20 ml NaCl bolus optimises intravenous contrast application.
MATHEMATICAL MODEL OF RUNOFF FROM GROOVED RUNWAYS (1984)

A conceptual model of runoff from grooved runways based on a hydraulically equivalent ungrooved surface has been investigated for its capability to simulate flow depths on a runway surface. The specific objective of model development is to predict runoff characteristics for uniform rainfall rates on a 100-foot wide concrete runway, grooved and sloping traversely at 1-1/2 percent. A FORTRAN IV computer program is used to solve the kinematic wave approximation to the shallow water equations which are central to the model. The kinematic wave approximation is employed for various hydraulic roughnesses as predicted from another study using a typical maxrotexture range of 0.01 inch to 0.03 inch. A rectangular groove shape with fixed dimensions is considered at five different spacings. The computer simulation results show that grooving enhances the drainage from the pavement in the form of decreased surface depths. The maximum depth reduction due to grooving is about 19 percent for all rainfall intensities, including the 6 inch per hour maximum in this study. These results are tentative, since an experimental study involving equipment that simulates rain on an indoor slab is presently underway. Qualitative observations of early experimental runs seem to indicate that depth reductions based on computer model runs may be too small.
Supplemental Figure 3 from Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma (2023)

&lt;p&gt;Serious adverse events unrelated to research.&lt;/p&gt;
Intelligent Modeling of Complex Manufacturing Processes Using Hierarchical Fuzzy Basis Function Networks (2001)

Abstract This paper presents a generalized modeling approach to modeling of complex manufacturing processes. Fuzzy basis function networks with a novel training algorithm are used to capture the cause-effect relationships of complex manufacturing processes. The modeling scheme allows for utilization of the existing knowledge in the form of analytical models, experimental data and heuristic rules in developing a suitable model. The method is implemented for the surface grinding processes based on the hierarchical structure of fuzzy basis function networks proposed by Lee and Shin [21]. Process models for surface roughness and residual stress are developed based on the available grinding model structures with a small number of experimental data to demonstrate the concept. The accuracy of developed models is validated through independent sets of grinding experiments.
Effect of dentin location and long-term water storage on bonding effectiveness of dentin adhesives (2011)

Dentin is a variable substrate with properties that change considerable in a single surface. The purpose of this study was to evaluate the bonding effectiveness to these different dentin locations and evaluate these differences over time. After bonding procedures with five different adhesives, small micro-tensile bond strength (µTBS) beams were prepared and dichotomously divided in 'center' and 'periphery' dentin specimens. After 1 week, 3, 6 and 12 months of water storage the µTBS of specimens of each group was determined, enabling a paired study design. The bond strengths of both etch&rinse adhesives were insensitive to regional variability. For the two-step self-etch adhesives, a marked increase in bond strengths was observed with increasing amount of intertubular dentin. Regional variability did not affect the long-term bonding effectiveness for any of the adhesives tested. In conclusion, only for the mild self-etch adhesives, µTBS to 'periphery' dentin was higher than for the 'center' specimens.
Real-Time Collaborative Heuristic Review: Meeting the Production Schedule Without Sacrificing Quality (2006)

Although most heuristic evaluation reports are provided to customers after the entire review process is complete, short production schedules sometimes demand real-time feedback from a heuristic evaluation team. In the past, this type of rapid turnaround has proven to be nearly impossible, but contemporary collaboration tools make real-time feedback a reality. This paper describes the process used by an accessibility evaluation team to provide real-time product feedback to customers. This evaluation team streamlined their current process, turning a highly serialized process into tasks that could be done in parallel by adding new software tools to allow them to work in a collaborative fashion. This improvement enabled rapid feedback to the customer and resulted in a real-time collaborative expert review process that can be used to conduct expert usability or accessibility reviews in any domain.
Excess Type I Interferon Signaling in the Mouse Seminiferous Tubules Leads to Germ Cell Loss and Sterility (2011)

Type I (α and β) interferons (IFNs) elicit antiproliferative and antiviral activities via the surface receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested that IFNα/β overexpression in the testis disrupts spermatogenesis. Here, we compare a new mouse strain transgenic for IFNβ (Tg10) and a sister strain lacking the IFNAR1 subunit of IFNAR (Tg10-Ifnar1(-/-)), both strains expressing the transgene in the testis. The main source of IFNβ RNA was the spermatid population. Importantly, the Tg10 mice, but not the double mutant Tg10-Ifnar1(-/-), showed altered spermatogenesis. The first IFNAR-dependent histological alteration was a higher apoptosis index in all germ cell categories apart from non-dividing spermatogonia. This occurred 3 weeks after the onset of IFNβ production at postnatal day 20 and in the absence of somatic cell defects in terms of cell number, expression of specific cell markers, and hormonal activities. Several known interferon-stimulated genes were up-regulated in Tg10 Sertoli cells and prepachytene germ cells but not in pachytene spermatocytes and spermatids. In concordance with this, pachytene spermatocytes and spermatids isolated from wild-type testes did not display measurable amounts of IFNAR1 and phosphorylated STAT1 upon IFNβ challenge in vitro, suggesting hyporesponsiveness of these cell types to IFN. At day 60, Tg10 males were sterile, and Sertoli cells showed increased amounts of anti-Mullerian hormone and decreased production of inhibin B, both probably attributable to the massive germ cell loss. Type I interferon signaling may lead to idiopathic infertilities by affecting the interplay between germ cells and Sertoli cells.
ChemInform Abstract: A Large‐Scale Synthesis of the Bioreductive Drug 1,4‐Bis{[2‐(dimethylamino)ethyl] amino}‐5,8‐dihydroxyanthracene‐9,10‐dione Bis‐N‐oxide (AQ4N). (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET (2021)

The novel tau-PET tracer [ 18 F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [ 18 F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [ 18 F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [ 18 F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 &amp; k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR 30-60 ) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1 SRTM : 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2 SRTM : 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p &lt; 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p &lt; 0.0001), lower SUVR 30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p &lt; 0.0001) and flatter slopes of the post-perfusion phase (slope 9-60 : 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p &lt; 0.0001) when compared to 3/4R-tau cases. [ 18 F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
ChemInform Abstract: The Mechanism of the Modified Ullmann Reaction (2011)

Abstract Review: 150 refs.
1-Phenylcyclobutylamine, the first in a new class of monoamine oxidase inactivators. Further evidence for a radical intermediate (1986)

1-Phenylcyclobutylamine (PCBA) is shown to be both a substrate and a time-dependent irreversible inactivator of monoamine oxidase (MAO). Inactivation results in attachment to the flavin cofactor. For every molecule of PCBA leading to inactivation, 325 molecules are converted to product. The first metabolite formed is identified as 2-phenyl-1-pyrroline; then after a lag time, 3-benzoylpropanal and 3-benzoylpropionic acid are generated. The 3-benzoylpropanal is a product of MAO-catalyzed oxidation of 2-phenyl-1-pyrroline (presumably, of its hydrolysis product, gamma-aminobutyrophenone). The aldehyde is nonenzymatically oxidized by nascent hydrogen peroxide to the carboxylic acid. These results are consistent with a one-electron oxidation of PCBA to the amine radical cation followed by homolytic cyclobutane ring cleavage. The resulting radical can partition between cyclization (an intramolecular radical trap) to the 2-phenylpyrrolinyl radical and attachment to the flavin. The cyclic radical can be further oxidized by one electron to 2-phenyl-1-pyrroline. PCBA represents the first in the cyclobutylamine class of MAO inactivators and strongly supports involvement of a radical mechanism for MAO-catalyzed amine oxidations.
Ultimate Sensitivity of Physical Sensor for Ammonia Gas Detection Exploiting Full Differential 3-Omega Technique (2017)

This paper is on the development of physical-based gas sensor for detection of highly toxic and corrosive ammonia. COMSOL simulation was used to study the effects of geometry on sensor sensitivity. The uniform cross-section micro-wire is shown to have the highest sensitivity to the surrounding gas. In order to further improve the sensor sensitivity, 3-Omega technique is combined with a differential electrical measurement. The proposed method enhances the sensor's performance for detection of low concentration gas ammonia in nitrogen, and reaches five hundred ppm for ammonia gas.
31P n.m.r. analysis of the renal response to respiratory acidosis (1982)

Conference Article| October 01 1982 31P n.m.r. analysis of the renal response to respiratory acidosis DOMINIQUE FREEMAN; DOMINIQUE FREEMAN *Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Search for other works by this author on: This Site PubMed Google Scholar MARTIN LOWRY; MARTIN LOWRY †Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEORGE RADDA; GEORGE RADDA *Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Search for other works by this author on: This Site PubMed Google Scholar BRIAN ROSS BRIAN ROSS †Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1982) 10 (5): 399. https://doi.org/10.1042/bst0100399 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation DOMINIQUE FREEMAN, MARTIN LOWRY, GEORGE RADDA, BRIAN ROSS; 31P n.m.r. analysis of the renal response to respiratory acidosis. Biochem Soc Trans 1 October 1982; 10 (5): 399. doi: https://doi.org/10.1042/bst0100399 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1982 Biochemical Society1982 Article PDF first page preview Close Modal You do not currently have access to this content.
Selectable frequency CMUT with membrane stand-off structures (2009)

A capacitive micromachined ultrasound transducer (CMUT) capable of selectable-frequency operation through membrane stand-off-controlled collapse-mode operation is presented using verified finite element analysis models. One method for fabricating stand-off structures is presented. Finite element analysis (FEA) simulations were verified with respect to a CMUT fabricated at the University of Virginia Microfabrication Laboratory (UVML) with a correlation coefficient of 0.92 and an amplitude error of 4.1% when comparing the time-domain pressure output signals. Stand-off geometry was optimized using an iterative FEA approach. The optimum spans for each of the four sub-membranes as a percent of the total membrane span are 32% for the central sub-membranes and 18% for the lateral sub-membranes. The stand-off CMUT device designed to operate at both 1.5MHz and 40MHz has been shown in simulation to posses comparable bandwidth to each of two conventional, single-frequency CMUTs operating at 1.5MHz and 40MHz, respectively with comparable bandwidth and a reduction in output intensity of 4.0dB and 4.5dB, respectively.
Fine-Grained Agent-Based Modeling to Predict Covid-19 Spreading and Effect of Policies in Large-Scale Scenarios (2022)

Modeling and forecasting the spread of COVID-19 remains an open problem for several reasons. One of these concerns the difficulty to model a complex system at a high resolution (fine-grained) level at which the spread can be simulated by taking into account individual features. Agent-based modeling usually needs to find an optimal trade-off between the resolution of the simulation and the population size. Indeed, modeling single individuals usually leads to simulations of smaller populations or the use of meta-populations. In this article, we propose a solution to efficiently model the Covid-19 spread in Lombardy, themost populated Italian region with about ten million people. In particular, the model described in this paper is, to the best of our knowledge, the first attempt in literature to model a large population at the single-individual level. To achieve this goal, we propose a framework that implements: i. a scale-free model of the social contacts combining a sociability rate, demographic information, and geographical assumptions; ii. a multi-agent system relying on the actor model and the High-Performance Computing technology to efficiently implement ten million concurrent agents. We simulated the epidemic scenario from January to April 2020 and from August to December 2020, modeling the government's lockdown policies and people's mask-wearing habits. The social modeling approach we propose could be rapidly adapted for modeling future epidemics at their early stage in scenarios where little prior knowledge is available.
+16 dBm High Power and High Linearity Integrated Photoreceiver for W-band Fiber Wireless Communication Applications (2019)

We designed and fabricated an 80-GHz range high-power integrated photoreceiver that is operated using a zero-bias operational broadband uni-traveling carrier photodetector and a high-gain narrow-band amplifier. The results showed that by applying a single power supply to the amplifier, the integrated photoreceiver could exhibit a higher power output at 1-dB power compression, i.e., over +16 dBm, and a 3-dB bandwidth of 6.5 GHz at 83 GHz.
Charge ambiguity and splitting of monopoles (2022)

This paper focuses on topological defects, appearing in mean-field-theory treatments of physical systems such as ultracold atomic gases and gauge field theories. We begin by investigating the ambiguity and addition of topological charges using the mathematical formalism of covering spaces, which clarifies many aspects these phenomena. Subsequently, we classify topological-defect configurations consisting of several monopoles and unknotted ring defects in terms of homotopy groups and fundamental-group actions on them, thus generalizing the previous classifications of a single monopole and a single unknotted ring defect. Finally, we examine the decay of multiply charged topological monopoles under small perturbations of the physical system, and analyze the conditions under which multiply charged monopoles are inclined to split into several singly charged monopoles.
Challenges in the interpretation of colorectal indocyanine green fluorescence angiography – A video vignette (2021)

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
CMOS charge-transfer preamplifier for offset-fluctuation cancellation in low-power A/D converters (1998)

We have developed a low-power, high-accuracy comparator composed of a dynamic latch and a CMOS charge transfer preamplifier (CT preamplifier). The CT preamplifier amplifies the input signal with no static power dissipation, and the operation is almost insensitive to the device parameter fluctuations. The low-power and high-accuracy comparator has been realized by combining the CT preamplifier with a dynamic latch circuit. The fluctuation in the offset voltage of a dynamic latch is reduced by a factor of the preamplifier gain. A 4-bit flash A/D converter circuit has been designed and fabricated by 0.6-/spl mu/m CMOS process. Low differential nonlinearity of less than /spl plusmn/4 mV has been verified by the measurements on test circuits, showing 8-bit resolution capability. Very low power operation at 4.3 /spl mu/W per MS/s per comparator has also been achieved.
A New C-methyl Isoflavone and Other Compounds from the Roots of Amphiblemma monticola(Melastomataceae) (2017)

The phytochemical study of the EtOH extract of the roots of Amphiblemma monticola Jacq.-Fél. led to the isolation of a new C-methyl isoflavone, amphiblemmone A (1), along with ten known compounds, including 3,4’-di- O-methylellagic acid (2), dimethyl 4,4’,5,5’,6,6’- hexahydroxybiphenyl-2,2’-dicarboxylate (3), lupeol (4), ellagic acid (5), β-sitosterol (6), sitosterol 3- O-β-D-glucopyranoside (7), 3-hydroxy-4,5-dimethoxybenzoic acid (8), 3- O-methylellagic acid 4′- O-β-D-xylopyranoside (9), and a mixture of oleanolic acid (10) and ursolic acid (11). The structures were elucidated using spectroscopic analyses (IR, UV, NMR and MS) and comparison with literature data. Compounds 2-11 were isolated for the first time from the genus Amphiblemma. This is the first report of compounds 2-4, 8 and 9 from the Melastomataceae family.