gebhart/patrepeval huggingface dataset:
Mutation Rate Switch inside Eurasian Mitochondrial Haplogroups: Impact of Selection and Consequences for Dating Settlement in Europe (2011)

R-lineage mitochondrial DNA represents over 90% of the European population and is significantly present all around the planet (North Africa, Asia, Oceania, and America). This lineage played a major role in migration "out of Africa" and colonization in Europe. In order to determine an accurate dating of the R lineage and its sublineages, we analyzed 1173 individuals and complete mtDNA sequences from Mitomap. This analysis revealed a new coalescence age for R at 54.500 years, as well as several limitations of standard dating methods, likely to lead to false interpretations. These findings highlight the association of a striking under-accumulation of synonymous mutations, an over-accumulation of non-synonymous mutations, and the phenotypic effect on haplogroup J. Consequently, haplogroup J is apparently not a Neolithic group but an older haplogroup (Paleolithic) that was subjected to an underestimated selective force. These findings also indicated an under-accumulation of synonymous and non-synonymous mutations localized on coding and non-coding (HVS1) sequences for haplogroup R0, which contains the major haplogroups H and V. These new dates are likely to impact the present colonization model for Europe and confirm the late glacial resettlement scenario.
Enhancing the Performance of Low Priority SUs Using Reserved Channels in\n CRN (2019)

Cognitive radio networks (CRNs) are considered a promising solution for\nspectrum resources scarcity and efficient channel utilization. In this letter,\nmulti-dimensional analytical Markov model based on reservation channel access\nscheme and channel aggregation method is proposed to enhance spectrum\nutilization, capacity of low priority secondary users (SUs) and reducing\nhandoff probability of SUs. Moreover, the proposed method improves the\nperformance of high priority SUs by providing the capability to resume the\nconnection after dropping. The numerical results indicate that the modified\nreservation access model can enhance the performance of SUs compared to the\ntraditional basic random access model.\n
Tailoring the Edge Structure of Molybdenum Disulfide toward Electrocatalytic Reduction of Carbon Dioxide (2016)

Electrocatalytic conversion of carbon dioxide (CO<sub>2</sub>) into energy-rich fuels is considered to be the most efficient approach to achieve a carbon neutral cycle. Transition-metal dichalcogenides (TMDCs) have recently shown a very promising catalytic performance for CO<sub>2</sub> reduction reaction in an ionic liquid electrolyte. Here, we report that the catalytic performance of molybdenum disulfide (MoS<sub>2</sub>), a member of TMDCs, can be significantly improved by using an appropriate dopant. Our electrochemical results indicate that 5% niobium (Nb)-doped vertically aligned MoS<sub>2</sub> in ionic liquid exhibits 1 order of magnitude higher CO formation turnover frequency (TOF) than pristine MoS<sub>2</sub> at an overpotential range of 50-150 mV. The TOF of this catalyst is also 2 orders of magnitude higher than that of Ag nanoparticles over the entire range of studied overpotentials (100-650 mV). Moreover, the in situ differential electrochemical mass spectrometry experiment shows the onset overpotential of 31 mV for this catalyst, which is the lowest onset potential for CO<sub>2</sub> reduction reaction reported so far. Our density functional theory calculations reveal that low concentrations of Nb near the Mo edge atoms can enhance the TOF of CO formation by modifying the binding energies of intermediates to MoS<sub>2</sub> edge atoms.
KCNQ1 and Long QT Syndrome in 1/45 Amish (2020)

This work provides a framework by which research exome sequencing can be rapidly translated in a culturally appropriate manner to directly benefit research participants and enable population precision health.
ChemInform Abstract: 3′‐Deoxyribofuranose Derivatives of 1‐Deaza and 3‐Deaza‐adenosine and Their Activity as Adenosine Deaminase Inhibitors (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Image-Based Deep Neural Network for Individualizing Radiotherapy Dose Is Transportable Across Health Systems (2023)

Our results support the development and implementation of new DL-guided treatment guidance tools in the image-replete and highly standardized discipline of radiation oncology.
STEREOVISION BY CORRELATION APPROACH ON-BOARD PERCEPTION SYSTEM CONCEPT AND (1992)

l%is paper presents a link part of the work currently developed at CEA. CNRS, IW, Oh’ERA and CNES in the framework of the Autonomous Planetary Rover program (V.A.P.). In the$rst part of the paper, a system concept approach for the VAP applicanbn is quickly presented. lhe second part is a special focus on the V.A.P. Perception System where we discuss and show some of the results obtained with the stereovision by correlation algorithm on outdoor simulated Mars terrain scenes. The overall program covers all the topics necessary for the design of an intervention robot such as a Mars rover. So, within the framework of Mars exploration, due to the significant time delay transmission and to terrain characteristics, the robotic challenge is to provide the highest degree of autonomy to the planetary rover [2]. In this paper, we try first to give a quick overview of a typical mission and of the associated system concept. In a second part, we describe the last improvements and associated tests results of a stereovision algorithm based on correlation technique.
Methods for producing secreted polypeptides (2023)

The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a second nucleotide sequence encoding the polypeptide, wherein the first nucleotide sequence is foreign to the second nucleotide sequence and the 3' end of the first nucleotide sequence is immediately upstream of the initiator codon of the second nucleotide sequence. The present invention also relates to the isolated signal peptide sequences and to constructs, vectors, and fungal host cells comprising the signal peptide sequences operably linked to nucleotide sequences encoding polypeptides.
<title>V-shaped switching in ferroelectric liquid crystals</title> (1999)

We have studied the three-component liquid crystal mixture reported by Inui et al. to exhibit `thresholdless antiferroelectricity', as well as some other materials with the same V-shaped (linear) electro-optic switching behavior. We find that thresholdless behavior is obtained in the absence of antiferroelectricity. The characteristic response of these materials is due to the field-induced switching of a twisted smectic C* structure stabilized by strong polar surface interactions. The twist is confined to thin surface regions by polarization charge effects leaving the bulk of the cell uniform, which gives almost complete extinction at zero field. Model calculations of the electro-optic response are in good agreement with the experimental data. In sufficiently thin cells, such thresholdless switching can in fact be followed down to much lower temperatures, where the bulk would be antiferroelectric but the cell is maintained in the ferroelectric state by hysteresis.
Mono‐ and Di‐Lanthanide Derivatives of 22‐Tungsto‐2‐antimonate(III), [Ln(H2O)4Sb2W21O72(OH)]10– and [Ln2(H2O)8Sb2W20O70)]8– (2013)

Abstract Abstract. The mono‐lanthanide‐containing [ Ln (H 2 O) 4 Sb 2 W 21 O 72 (OH)] 10– ( Ln = Yb ( 1 ), Lu ( 2 )), and the di‐lanthanide‐containing [ Ln 2 (H 2 O) 8 Sb 2 W 20 O 70 )] 8– ( Ln = Yb ( 3 ), Lu ( 4 ), Y ( 5 )) have been synthesized in aqueous‐acidic media and characterized in the solid state. Polyanions 1 and 2 were prepared by reaction of Ln 3+ ions with [Sb 2 W 22 O 74 (OH) 2 ] 12– ( Sb 2 W 22 ), whereas 3 – 5 were prepared by using the trilacunary 9‐tungstoantimonate(III) [ B‐α‐ SbW 9 O 33 ] 9– ( SbW 9 ). Polyanions 1 – 5 crystallized as sodium salts in the triclinic system, space group P $\bar{1}$ . All compounds were characterized in the solid state by FTIR, single‐crystal XRD, TGA, and elemental analysis. Polyanions 1 – 5 contain the lacunary [Sb 2 W 20 O 70 ] 14– unit ( Sb 2 W 20 ), which is coordinated to either a lanthanide and a tungsten ion, leading to a structure with C s symmetry in polyanions 1 and 2 , or to two lanthanide ions, leading to a structure with idealized C 2 h symmetry, in polyanions 3 – 5 .
Program analysis for safety guarantees in a Java virtual machine written in Java (2001)

In this paper, we report on our experiences with guaranteeing GC-pointer safety when using unsafe low-level language extensions to implement a JVM in Java. We give an overview of the original unsafe language extensions that were defined for use by Jalapeño implementers, and introduce sanitized replacements that capture common idioms while also guaranteeing GC-pointer safety. We also outline some simple static and dynamic checks for correct usage of low-level operations, and examine how code containing low-level operations can be optimized correctly and effectively.
Solution-processed gadolinium doped indium-oxide thin-film transistors with oxide passivation (2017)

We studied the effect of Gd doping on the structural properties of solution processed, crystalline In2O3 for thin-film transistor (TFT) application. With increasing Gd in In2O3 up to 20%, the material structure changes into amorphous phase, and the oxygen vacancy concentration decreases from 15.4 to 8.4%, and M-OH bonds from 33.5 to 23.7%. The field-effect mobility for the Gd doped In2O3 TFTs decreases and threshold voltage shifts to the positive voltage with increasing Gd concentration. In addition, the stability of the solution processed TFTs can also be improved by increasing Gd concentration. As a result, the optimum Gd concentration is found to be ∼5% in In2O3 and the 5% Gd doped In2O3 TFTs with the Y2O3 passivation layer exhibit the linear mobility of 9.74 cm2/V s, the threshold voltage of −0.27 V, the subthreshold swing of 79 mV/dec., and excellent bias stability.
Physics based system simulation for robot electro-mechanical control design (2017)

The aim of our investigation is to develop complete electro-mechanical system simulation. The present developed prototype system includes pressure sensors, amplifiers, a controller, servo motors, and a robot-body. Sensor signals such as transduced voltage, servo motor actuation signals such as shaft angle, velocity, and acceleration are modeled in an analytical way. The entire system structure is formed based on the equivalent circuit concept. Mechanical dynamics of a two-leg robot-body is verified with the developed simulation system.
Exposure–Response Relationships for Efficacy and Safety of Risankizumab in Phase II and III Trials in Psoriasis Patients (2019)

Risankizumab has demonstrated efficacy in phase III trials in patients with moderate-to-severe plaque psoriasis. The exposure-response relationships for risankizumab efficacy (Psoriasis Area and Severity Index (PASI)75, PASI90, PASI100, and static Physician's Global Assessment (sPGA)0/1) at week 16 (N = 1,732) and week 52 (N = 598) as well as safety (incidence of any adverse event, serious adverse event, infection and infestation, or serious infection) over up to 52 weeks were characterized using the data from risankizumab phase II and III clinical trials in patients with moderate-to-severe plaque psoriasis. Impact of clinically relevant covariates was evaluated. Risankizumab phase III regimen (150 mg subcutaneously at weeks 0, 4, and every 12 weeks thereafter) achieved the plateau of the exposure-efficacy relationships with model-estimated PASI90 and sPGA0/1 response probabilities of 77%, and 87%, respectively, at week 16 and 85%, and 88%, respectively, at week 52. There was no apparent relationship between risankizumab plasma exposure and the evaluated safety variables.
Novel Synthesis of Unsymmetrical Diarylbutadiynes (1988)

Terminal arylbutadiynes, derived from 6-aryl-3,5-hexadin-2-ols, undergo a ready palladium-catalyzed coupling with activated aryl halides in the presence of a phase transfer catalyst to unsymmetrical diarylbutadiynes, not easily available by other coupling procedures.
Application of Pyrolysis Mass Spectrometry to the Classification and Identification of Mycobacteria (1981)

Application of modern pyrolysis techniques offers the possibility for mass spectrometric analysis of complete bacterial cells. It was shown that pyrolysis mass spectra provide fingerprints of mycobacterial cells that are characteristic on the (sub)species level. Computer-aided comparisons of the spectra for mycobacteria were used for identification of unknown strains as members of either the "tuberculosis complex" (Mycobacterium tuberculosis, Mycobacterium bovis-BCG, M. bovis) or of the group referred to as "atypical mycobacteria." Pyrolysis mass spectrometry was performed with a completely automated instrument, and spectra were evaluated by two computerized numerical methods. The first method has general applicability to mass spectrometry data, while the second was devised for the routine identification of the "tuberculosis complex." With use of the latter method, 125 strains were identified. A positive correlation of 94.4% was found between the results of this method and the results of the usual bacteriologic procedures; 1.6% of all strains were given a falsely negative identification, and 4.0% were given a falsely positive identification.
Portierung von Merkmalsextraktion auf die PocketPC-Plattform (2005)

Diese Arbeit stellt eine Softwarelösung zur Extraktion von phonetischen Merkmalen, die als Grundlage für andere Applikationen dienen, aus einem digitalen Sprachsignal auf der PocketPC-Plattform vor. Die Entwicklung der Lösung wird schrittweise von der Festlegung der Kriterien über den Entwurf bis hin zur Implementierung beschrieben. Das Ergebnis ist eine fertige Bibliothek, welche die geforderten Merkmale bietet. Zuvor wird ein kurzer Überblick über das Projekt M31, in dessen Rahmen diese Arbeit entstand, sowie die computergestützte Sprachanalyse im Allgemeinen gegeben. Darüber hinaus werden einige softwaretechnische Aspekte der Applikationsportierung angesprochen und im Hinblick auf die mobile Plattform konkretisiert.
Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. (2003)

Cancer-testis (CT) antigens are ideal vaccine targets since their expression is restricted in adult tissues to testicular germ cells and a subset of cancers. The frequency of expression in transitional cell carcinomas (TCCs) of NY-ESO-1, the most immunogenic CT antigen to date, and its closely related gene LAGE-1 was studied. NY-ESO-1 and LAGE-1 antigen expression were found to occur frequently in high-grade TCC tumors. On an MSKCC IRB-approved protocol, 68 patient specimens were collected prospectively at the time of transurethral resection or cystectomy, of which 43 were read pathologically as high-grade tumors (pCIS, pTaG3, pT1, pT2, pT3, and pT4), 8 as low-grade tumors (pTaG1, pTaG2), and 17 as disease-free samples. These 68 samples were analyzed by immunohistochemistry (IHC) and/or RT-PCR. There were also an additional 53 paraffin-embedded specimens studied retrospectively by IHC, of which 39 were high-grade tumors and 14 were low-grade tumors. Cumulatively, our data indicate that NY-ESO-1 and/or LAGE-1 are expressed in 39/82 (48%) high-grade TCC and 3/22 (14%) low-grade TCC samples when analyzed by RT-PCR and/or IHC. Immunological assessment of these patients' sera identified one patient, whose tumor homogeneously expressed NY-ESO-1, which had detectable antibodies against NY-ESO-1 and LAGE-1. Further analysis of this patient, who remains clinically without evidence of disease 24 months after cystectomy for high-grade pT4 disease, revealed T-cell immunity against NY-ESO-1. This patient's T-cell response was determined to be specific for a new NY-ESO-1 epitope, p94-102, in the context of HLA-B35.
Training faculty to coach capstone design teams (2001)

During senior capstone experiences, student teams are often given a faculty advisor to teach andassist them. Our experience has shown that using the traditional student/faculty teaching model isnot an efficient or effective approach to the student learning of design and team processes. Theobjective of the paper is to show that successful learning experiences for capstone design teamsrequire faculty to shift their role from a traditional lecture or consulting role to a coaching role.Research into key indicators of engineering design team success related to coaching focused onteam observations, individual and team interviews, and individual team member and coach surveys.Results shows that a successful coaching role encompasses three main responsibilities: mentor,mediator and manager. Specific expectations and activities that a coach should fulfill to aid in thesuccess of capstone teams can be established.
Correction to: Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease (2016)

In the original publication of this article [1] Fig. 1 was incorrect due to the use of a colour bar with wrong range in error.
Preparation and characterization of the conjugatedFusariummycotoxins zearalenone-4O-β-D-glucopyranoside, α-zearalenol-4O-β-D-glucopyranoside and β-zearalenol-4O-β-D-glucopyranoside by MS/MS and two-dimensional NMR (2009)

Glucosides of several Fusarium mycotoxins occur in naturally infected cereals and may contribute to an increased content to the total mycotoxin load of food and feed. The paper presents the results of a fermentation procedure to produce zearalenone-4O-beta-D-glucopyranoside from zearalenone using an engineered Saccharomyces cerevisiae strain, expressing the Arabidopsis thaliana UDP-glucosyltransferase UGT73C6. About 24 mg of zearalenone-4O-beta-D-glucopyranoside was obtained from 50 mg of zearalenone and further purified. A total of 10 mg of the glucoside were reduced with sodium borohydride, yielding 4.1 mg alpha-zearalenol-4O-beta-D-glucopyranoside and 4.5 mg beta-zearalenol-4O-beta-D-glucopyranoside at purities higher than 99%. To confirm the identities of the three produced glucosides, MS and MS/MS spectra were acquired using negative electrospray ionization. Besides the deprotonated ions at m/z 479 or 481, respectively, in full-scan mode, fragments, adducts, and dimers were recorded and assigned. MS/MS spectra of the glucosylated substances yielded the deprotonated ions of the mycotoxins zearalenone, alpha-zearalenol, beta-zearalenol and their fragments, respectively. Unambiguous structural assignment of the three substances was achieved using two-dimensional NMR methods. This way, the glucose attachment to position C-4, the beta-configuration of the sugar unit and the stereo-chemical assignment of the zearalenol hydroxyl group at C-6' were proven.
An adaptive mesh numerical algorithm for the solution of 2D Neel type walls (1994)

It is shown that, in spite of the introduction of an adaptive meshing along the normal to the wall plane, the micromagnetic calculation of 2D symmetrical Neel walls in ultra-thin films still requires a large number of mesh points before reaching numerical stability, in opposition to the 1D case.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Opportunistic Scheduling in Underlay Cognitive Radio based Systems: User\n Selection Probability Analysis (2018)

In this paper, an underlay cognitive radio (CR) system is considered with\nmultiple cognitive or secondary users contending to transmit their information\nto the cognitive destination (e.g., eNodeB) using the spectral resource of a\nprimary user. The novel closed-form expressions are derived for the selection\nprobabilities of cognitive users with opportunistic scheduling wherein an\noptimal metric is employed for opportunistic transmission. The analytical\nresults corroborated by the Monte Carlo simulations, can be used to demonstrate\nthe fairness achieved in opportunistic scheduling. It is shown that the\nfairness in terms of equal chance for transmission amongst all cognitive users\ncan only be seen for the scenarios when the fraction of distances between the\ncognitive transmitter and cognitive receiver, and cognitive transmitter and\nprimary receiver is identical for each of the cognitive transmitters.\n
Reactions of N-aryl nitrogen oxides. 1. Selective ortho chlorination in the reactions of aryl nitrones and amine oxides with thionyl chloride or phosgene (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of N-aryl nitrogen oxides. 1. Selective ortho chlorination in the reactions of aryl nitrones and amine oxides with thionyl chloride or phosgeneDennis Liotta, A. D. Baker, Stephen Goldstein, Norman L. Goldman, Francine Weinstein-Lanse, Diane Felsen-Reingold, and Robert EngelCite this: J. Org. Chem. 1974, 39, 18, 2718–2722Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://doi.org/10.1021/jo00932a011RIGHTS & PERMISSIONSArticle Views195Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (675 KB) Get e-Alerts Get e-Alerts