gebhart/patrepeval huggingface dataset:
LPV-MPC Path Planning for Autonomous Vehicles in Road Junction Scenarios (2021)

The control of an autonomous host vehicle at a crossroads intersection, in the presence of uncoordinated target vehicles, and without any crossing priority regulation is considered. The problem was spilt into two sub-problems, namely the priority and the path-planning problems. These problems are solved using a hierarchical controller. The lower control level is a linear controller to control the vehicle's speed and heading, to follow the reference signals provided by a middle-level algorithm. This middle-level controller is a Model Predictive Control (MPC) computed by modelling a unicycle model that is in a Linear Parameter-Varying (LPV) state-space model form. Different features are introduced for improving the prediction capability of the LPV-MPC. Prediction data computed by the MPC are used by the higher-level state-machine supervisor algorithm to determine when the host vehicle can safely cross the junction. The hierarchical controller was tested in simulation using a set of stressing scenarios. Reported results show the effectiveness of the proposed LPV-MPC in managing complex traffic scenarios with efficient compute.
A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's diseaseYan Xia and Alan P. KozikowskiCite this: J. Am. Chem. Soc. 1989, 111, 11, 4116–4117Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ja00193a062https://doi.org/10.1021/ja00193a062research-articleACS PublicationsRequest reuse permissionsArticle Views1663Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
New Insights into Physical Aging‐Induced Structure Evolution in Carbon Molecular Sieve Membranes (2022)

Abstract Carbon molecular sieve (CMS) membranes offer the best available combination of scalable economical processability with excellent separation performance. Physical aging of CMS membranes causes pore structure changes over time that affect CMS membrane performance. To provide fundamental insights into the structure evolution in CMS membranes during physical aging, a combined dual‐mode sorption and transport model is used in this study to characterize the diffusion coefficients of gas molecules in fresh and 7‐day vacuum aged CMS membranes. The results show physical aging of CMS membrane is primarily “diffusion related” and such aging behavior simultaneously causes ultramicropore changes in the continuous phase and Langmuir phase of CMS membrane. The new insights offered in this study suggest strategies to control the physical aging of CMS membranes and even use it as a valuable tool to tune the separation performance of CMS membranes for demanding gas separations.
Detection of <I>K-ras </i>Mutations by a Microelectronic DNA Chip (2004)

The increased knowledge of the human genome, thanks to its sequencing and to the accumulation of data that ensue from it, prompts the characterization of disease-causing genes. Especially because of the continuing expansion of cancer-related gene discovery, oncobiology is a discipline that is undergoing rapid change. Detection of point mutations in oncogenes or tumor suppressor genes associated with the multistep process of oncogenesis could be of value in patient management. These potential molecular tumor markers are essential not only for the diagnosis, prognosis, or the follow-up of the disease but also for the management of therapy (,). Particularly, the K-ras protooncogene is altered, by point mutations within codons estimated to be critical for the biological activity of the protein (codons 12, 13, or 61), in a wide variety of tumors (). The incidence of these mutations can reach 95% in pancreatic carcinoma () and occurs in 40–60% of colorectal cancers, where they are associated with the progression from adenoma to carcinoma (). The detection of K-ras mutations enables the understanding of cancer biology and pathogenesis with, for example, a role in the mucinous differentiation pathway (). Alterations involving this oncogene may be of clinical importance because they can provide information for early diagnosis and clinical outcome. Their analysis within the tumor makes them of prognostic value (risk of relapse, mortality) (). Moreover, activation of the K-ras gene has been detected not only in the tumor but also in the stools () of patients with colorectal cancer.
Effects of correlation window length and reflection amplitude on axial displacement measurements using cone phantoms (2009)

Correlation based displacement estimation techniques are widely used in the field of ultrasound elastography. Changes in the underlying echo pattern due to mechanical excitation allow the detection of local displacements. In the presence of bright reflections due to an acoustic impedance mismatch, a displacement estimation bias may occur resulting in image blurring. The goal of this study was to measure the effects of correlation window length and boundary reflections on axial displacement measurements using a cone phantom. A 2D MATLAB simulation was developed to model this system. Displacements were estimated using windowed normalized cross-correlation. Windows ranged in length from 0.2 mm to 2.9 mm (1.3 ¿ to 20 ¿ given f = 5.33 MHz and c = 1540 m/s). A line of scatterers were located on the edge of the wedge and assigned a higher amplitude in order to simulate a bright reflection. The location on the wedge axis where the displacement was half the maximum displacement at the base of the wedge was identified. The axial wedge width at that location was reported as the resolution. Axial resolution measurements were linearly proportional to window length. Resolution was approximately 0.8 mm given a 0.6 mm window length with a reflection that was 5 times the amplitude of the surrounding speckle, and 0.4 mm without a reflection for our set of parameters. A preliminary experiment was also performed in which a tissue-mimicking cone phantom was imaged using an Acoustic Radiation Force Impulse (ARFI) Imaging system to measure the effects of the reflective boundary as a function of correlation window length.
The ICSI Summarization System at TAC 2008. (2008)

The ICSI multi-document summarization system relies on a general framework that casts summarization as a global optimization problem with an integer linear programming solution. Our primary submission, a simple sentence extractor with an n-gram frequency heuristic, gives results at least as good as any reported on the non-update part of the main task. Our secondary submission adds compressed sentence alternatives, achieving high ROUGE scores but lower manual scores. We also observe that an oracle version of our sentence extractor is nearly a direct optimization of ROUGE. We show oracle results for the TAC data set and discuss their significance. Finally, we provide a detailed analysis of the linguistic quality of our two systems, suggesting specifically where improvements might be most useful. 1
Lithographic qualification of high-transmission mask blank for 10nm node and beyond (2016)

In this paper, we discuss the lithographic qualification of high transmission (High T) mask for Via and contact hole applications in 10nm node and beyond. First, the simulated MEEF and depth of focus (DoF) data are compared between the 6% and High T attnPSM masks with the transmission of High T mask blank varying from 12% to 20%. The 12% High T blank shows significantly better MEEF and larger DoF than those of 6% attnPSM mask blank, which are consistent with our wafer data. However, the simulations show no obvious advantage in MEEF and DoF when the blank transmittance is larger than 12%. From our wafer data, it has been seen that the common process window from High T mask is 40nm bigger than that from the 6% attnPSM mask. In the elongated bar structure with smaller aspect ratio, 1.26, the 12% High T mask shows significantly less develop CD pull back in the major direction. Compared to the High T mask, the optimized new illumination condition for 6% attnPSM shows limited improvement in MEEF and the DoF through pitch. In addition, by using the High T mask blank, we have also investigated the SRAF printing, side lobe printing and the resist profile through cross sections, and no patterning risk has been found for manufacturing. As part of this work new 12% High T mask blank materials and processes were developed, and a brief overview of key mask technology development results have been shared. Overall, it is concluded that the High T mask, 12% transmission, provides the most robust and extendable lithographic solution for 10nm node and beyond.
Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer (2022)

Abstract Lung cancer is the leading cause of cancer-related mortality among both men and women in the United States. Immune checkpoint blockade has emerged as a promising therapy for advanced non-small cell lung cancer (NSCLC); however, only a subset of patients responds to this treatment regimen. Therefore, combinatorial therapeutic strategies to enhance anti-tumor immunity and efficacy of immunotherapy are in urgent need. Our group and others have demonstrated the potential of MYC inhibition in NSCLC to render the tumor microenvironment (TME) more immune permissive by upregulating antigen presentation machinery and chemokines that recruit effector lymphocytes. We performed a dedicated reanalysis of published transcriptome data from two distinct cancer types, prostate and lung, which were treated with novel MYC inhibiting agents, MYCi975 and Omomyc, respectively. These data revealed augmentation of two class IIa histone deacetylases (HDACs), HDAC5 and HDAC9, upon MYC inhibition. In addition to the suggested interaction between MYC and Class IIa HDACs derived from our transcriptional analyses, class IIa HDACs have an established role in tumorigenesis, angiogenesis, and poor prognosis of cancer patients, thus implying that therapeutic benefits could be derived from dual inhibition of MYC and class IIa HDAC. Elucidation of the basal relationship between Class IIa HDACs and the immune microenvironment of NSCLC was derived through correlative analyses of TCGA Lung adenocarcinoma and squamous carcinoma RNA-seq data. These data revealed a conserved positive correlation across non-small cell lung cancer between class IIa HDAC RNA levels, Treg score, and Treg/CD8 ratio by immune deconvolution analysis. Evaluation of combinatorial treatment efficacy of MYCi plus Class IIa HDACi was undertaken using 19 NSCLC cell lines, which recapitulate the mutational and histological landscape of NSCLC. These data identified a genotype-driven drug synergy, wherein EGFR mutant cell lines presented as resistant, and Ras mutant cell lines presented as sensitive to our combination drug paradigm. In summary, we defined a positive association between Class IIa HDAC expression and Treg score in TCGA NSCLC samples, suggesting a possibility of immune-modulation via class IIa HDAC inhibition. Furthermore, we identified transcriptional augmentation of class IIa HDAC induced by MYC repression, which indicates a potential novel therapeutic opportunity. Finally, we determined that inhibition of class IIa HDACs potentiates MYC inhibitor-driven anti-tumor efficacy across a diverse set of NSCLC cell lines. Citation Format: Jina Park, Michelle Vaz, Ray-Whay C. Yen, Stephen B. Baylin, Michael J. Topper. Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3280.
Ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine‐rich domains 2 and 5 (2004)

Tumor necrosis factor (TNF)-alpha converting enzyme (TACE) is responsible for the ectodomain release of various membrane proteins by proteolytic cleavage in close proximity to the cell membrane. Despite the wide spectrum of possible substrates, selective cleavage can be achieved by substrate cross-linking. To explore the underlying mechanism, we studied the TACE-mediated shedding of CD30. Whereas the constitutive release of the soluble ectodomain of CD30 (sCD30) from the lymphoma cell line Karpas 299 was enhanced by most anti-CD30 antibodies, it was inhibited by antibodies Ber-H2 and Ki-4. On the basis of the recognized epitopes, shedding seemed to depend on the availability of the cysteine-rich domains (CRD) 2 and 5 of the CD30 ectodomain. CRD2 and 5 have almost identical amino acid sequences and are localized distant from the TACE-targeted cleavage site. Soluble CD30, the product of this enzyme reaction, did not inhibit, but on the contrary, it stimulated CD30 shedding in a CRD2/5-dependent manner. This process could also be induced by CRD2/5-derived peptides but not by a CRD1-derived control peptide. This example of a product-activation was CD30 selective since other TACE substrates such as TNFR1 or TNF-alpha were not affected. These data suggest that CD30 shedding is stimulated by an elevated local availability of CRD2 or 5, possibly by forming a docking station for the releasing enzyme through substrate aggregation.
Influence of melt stability on the crystallization of bis(4‐aminophenoxy)benzene‐oxydiphthalic anhydride based polyimides (1996)

Abstract Novel high performance semicrystalline polyimides, based on controlled molecular weight phthalic anhydride (PA) endcapped 1,4‐bis(4‐aminophenoxy)benzene (TPEQ diamine) and oxydiphthalic dianhydride (ODPA), were synthesized. They exhibited excellent thermal stability in nitrogen and air atmospheres as determined by thermogravimetric analysis (TGA). The glass transition temperatures ( T g ) for these polymers ranged from 225°C for the 10,000 M n (10K) polymer, to 238°C for the 30,000 (30K) M n material. The observed melting temperatures for all the polymers were ∼420°C. The crystallization behavior of these polymers showed a strong molecular weight dependence, as illustrated by the observation that the 10K and 12.5K polymers crystallized with relative ease, whereas the 15K, 20K, and 30K polymers showed little or no ability to undergo thermal recrystallization. The thermal stability of these polymers above T m was investigated by studying the effect of time and temperature in the melt on the cold crystallization and melting of these polymers. Increased time and temperature in the melt resulted in lower crystallinity because of melt state degradation, such as crosslinking and branching, as evidenced by an increase in melt viscosity, which was more prominent for the higher molecular weight polymers.
Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation (2001)

BMI-1 and EZH2 Polycomb-group (PcG) proteins belong to two distinct protein complexes involved in the regulation of hematopoiesis. Using unique PcG-specific antisera and triple immunofluorescence, we found that mature resting peripheral T cells expressed BMI-1, whereas dividing blasts were EZH2(+). By contrast, subcapsular immature double-negative (DN) (CD4(-)/CD8(-)) T cells in the thymus coexpressed BMI-1 and EZH2 or were BMI-1 single positive. Their descendants, double-positive (DP; CD4(+)/CD8(+)) cortical thymocytes, expressed EZH2 without BMI-1. Most EZH2(+) DN and DP thymocytes were dividing, while DN BMI-1(+)/EZH2(-) thymocytes were resting and proliferation was occasionally noted in DN BMI-1(+)/EZH2(+) cells. Maturation of DP cortical thymocytes to single-positive (CD4(+)/CD8(-) or CD8(+)/CD4(-)) medullar thymocytes correlated with decreased detectability of EZH2 and continued relative absence of BMI-1. Our data show that BMI-1 and EZH2 expression in mature peripheral T cells is mutually exclusive and linked to proliferation status, and that this pattern is not yet established in thymocytes of the cortex and medulla. T cell stage-specific PcG expression profiles suggest that PcG genes contribute to regulation of T cell differentiation. They probably reflect stabilization of cell type-specific gene expression and irreversibility of lineage choice. The difference in PcG expression between medullar thymocytes and mature interfollicular T cells indicates that additional maturation processes occur after thymocyte transportation from the thymus.
Immunoreactivity of Cryptococcal Antigen Is Not Stable under Prolonged Incubations in Human Serum (2004)

The stability of cryptococcal antigen from Cryptococcus neoformans serotype A and D strains at different temperatures in serum and other solvents was studied. Samples stored at -20 or 4 degrees C had equivalent stabilities as measured by the Premier Cryptococcal Antigen kit and the Cryptococcal Antigen Latex Agglutination System (CALAS) kit. However, using the Premier Cryptococcal Antigen kit, there was a 91% loss of reactivity in samples incubated in human serum for 4 weeks at 37 degrees C. A loss of reactivity of more than 99% was observed after incubation at 45 degrees C for 4 weeks. The capsular antigen was not detected by the Premier Cryptococcal Antigen kit after 16 weeks at elevated temperatures. Antigen titers were also reduced in a latex agglutination assay (CALAS) after 4 weeks at 37 and 45 degrees C. The loss of antigen reactivity was a function of pH and temperature.
CloisiteNa+/LLDPE – Composite: Effect of layered silicate on the thermal, mechanical and photo-oxidation properties (2007)

Recently a considerable effort has been dedicated toward preparation of polymer/layer nanocomposites (polymer layered silicate (PLS) nanocomposites or polymer clay nanocomposites (PCNC)), which consist of a polymer matrix with a dispersed organic nanolayer. These composites have received considerable attention in fundamental research and industry. Interest in polyolefin nanocomposites has emerged due to their promise of improved performance in packaging and engineering applications. The most representative PE grades found in today’s market are LDPE, LLDPE and HDPE.1 Several workers have highlighted studies on the different structures of melt compounded clay and polyolefins, and the effect on the mechanical and thermal properties. These nanocomposites exhibit enhanced properties at very low filler content compared to conventional filled polymers, (usually inferior to 5 wt%) such as increased Young’s modulus, thermal stability, barrier properties, decreased gas/vapour permeability and good flame retardancy
Features of the introduction of an information system for monitoring the movement of medicines in civil and military health care (2020)

Abstract. The features of the introduction of an information system for monitoring the movement of medicines in civil and military health care are considered. It has been shown that in order to counteract the inflow of substandard, falsified and counterfeit medicines to medical and pharmacy organizations, from July 1, 2020, all subjects of their circulation in the Russian Federation are required to enter the necessary information into the automated information system for monitoring the movement of medicines. The preliminary results of the experiment on labeling with control (identification) marks of medicines and monitoring of their circulation are evaluated. It is noted that the introduction of an automated information monitoring system in practice is associated with a number of problems that contribute, in particular, to an increase in the cost of medicines. It was established that in the formation of regulatory mechanisms for monitoring the movement of medicines,the specifics of drug provision in military health care were practically not taken into account, which in turn led to the emergence of a number of legal conflicts. It was revealed that, on the one hand, the obligations to participate in the medicine movement monitoring system have been lifted for the Ministry of Defense, the Federal Security Service, the Foreign Intelligence Service, and, on the other hand, other power ministries and departments must provide the required information to the system. It was emphasized that, given all the problematic issues, the introduction of an information monitoring system has a positive effect on the activities of drug circulation entities, as well as enhancing the effectiveness of drug provision for citizens. It is advisable to provide for separate participation in the information system for monitoring the movement of medicines of the Ministry of Defense and some other power ministries and departments, providing the opportunity, on equal terms with other participants, to confirm the quality of the medicines in circulation.
Examination Methods for General Joint Laxity (2009)

スポーツ障害予防のmedical checkや結合組織疾患の病態評価の1つに全身関節弛緩性（以下，GJL）の評価がある．我々の渉猟し得る範囲では，GJLの評価法の検者内・検者間信頼性についての報告はない．今回，代表的なGJLの評価法である，Carter法，Beighton法，東大式法の評価法について検討した．対象は当大学の運動部に所属する学生40名（全例男性，平均年齢20.5歳）である．統計は級内相関係数（以下，ICC）を使用した．各評価法とも検者内信頼性は高かった．検者間信頼性も高かったが，3法中ではCarter法が低く，東大式法が最も高かった．測定する関節によってICCの値に大きな差を認めた．今後は角度測定の際の基準を設ける必要性があり，目的に応じて測定する関節，関節数，測定方法を決定する必要性があると思われた．