gebhart/patrepeval huggingface dataset:
High Throughput Surface Characterisation of a Combinatorial Material Library (2007)

The figure shows a schematic representing the information that can be obtained from the surface of each polymer sample within the microarrayed library. High throughput surface analytical techniques used include X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry and water contact angle measurement. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c0949_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Improving text passwords through persuasion (2008)

Password restriction policies and advice on creating secure passwords have limited effects on password strength. Influencing users to create more secure passwords remains an open problem. We have developed Persuasive Text Passwords (PTP), a text password creation system which leverages Persuasive Technology principles to influence users in creating more secure passwords without sacrificing usability. After users choose a password during creation, PTP improves its security by placing randomly-chosen characters at random positions into the password. Users may shuffle to be presented with randomly-chosen and positioned characters until they find a combination they feel is memorable. In this paper, we present an 83-participant user study testing four PTP variations. Our results show that the PTP variations significantly improved the security of users' passwords. We also found that those participants who had a high number of random characters placed into their passwords would deliberately choose weaker pre-improvement passwords to compensate for the memory load. As a consequence of this compensatory behaviour, there was a limit to the gain in password security achieved by PTP.
Ionic Liquids as Performance Additives for Electroenzymatic Syntheses (2009)

Electroenzymatic syntheses combine oxidoreductase-catalysed reactions with electrochemical reactant supply. The use of ionic liquids as performance additives can contribute to overcoming existing limitations of these syntheses. Here, we report on the influence of different water-miscible ionic liquids on critical parameters such as conductivity, biocatalyst activity and stability or substrate solubility for three typical electroenzymatic syntheses. In these investigations promising ionic liquids were identified and have been used as additives for batch electrolyses on preparative scale for the three electroenzymatic systems. It was possible to improve the space-time-yield for the electrochemical regeneration of NADPH by a factor of three. For an amino acid oxidase catalysed resolution of a methionine racemate with ferrocene-mediated electrochemical regeneration of the enzyme-bound cofactor FAD a 50% increase in space time yield and 140% increase in catalyst utilisation (TTN) were achieved. Furthermore, for the chloroperoxidase-catalysed synthesis of (R)-phenylmethylsulfoxide with electrochemical generation of the required cosubstrate H2O2 the space time yield and the catalyst utilisation were improved by a factor of up to 4.2 depending on the ionic liquids used.
Bridging therapeutic opportunities: a survey by the Italian molecular tumor board workgroup of Alliance Against Cancer (2022)

MTB networking is crucial not only for molecular diagnosis and therapy assignment, but also for healthcare governance. Survey results show that MTBs review therapeutic opportunities at the crossover between standard-of-care with off-label, the former task being much beyond their scope. Societal and scientific implications of this beyond-the-scope MTB function may be relevant for healthcare in Italy and abroad.
Synthesis and Structure of As-Prepared ITQ-4, A Large Pore Pure Silica Zeolite:  The Role and Location of Fluoride Anions and Organic Cations (1998)

Pure silica ITQ-4, a zeolitic material with large one-dimensional 12MR channels and an unexpectedly large microporous void volume, can be synthesized in the presence of fluoride ions and N-benzylquinuclidinium cations within a wide range of synthesis pH. Substitution of the tertiary carbon of the quinuclidine moiety by a N atom still renders the organic cation as a suitable structure-directing agent for this material. The role of F- anions and the influence of the pH of the synthesis on both the phase selectivity of the crystallization and the presence of connectivity defects in the final material are discussed. In the presence of F-, defect formation is observed to be pH-dependent, and there appears to be a threshold pH for the generation of a constant defect concentration. A plausible explanation for this observation based upon the ionization state of the condensing species is also presented. The structure of as-made ITQ-4 has been obtained and refined from high-resolution powder XRD data, and the organic and fluoride ions have been located. The sinuosity of the channel of ITQ-4 is found to coincide with the bent geometry observed for the structure-directing agent, while the fluoride ions are found to reside within a small [43526] cage located around the periphery of the central pore space.
Associative Charge Transfer Reactions. Temperature Effects and Mechanism of the Gas-Phase Polymerization of Propene Initiated by a Benzene Radical Cation (2006)

In associative charge transfer (ACT) reactions, a core ion activates ligand molecules by partial charge transfer. The activated ligand polymerizes, and the product oligomer takes up the full charge from the core ion. In the present system, benzene(+*) (Bz(+*)) reacts with two propene (Pr) molecules to form a covalently bonded ion, C(6)H(6)(+*) + 2 C(3)H(6) --> C(6)H(12)(+*) + C(6)H(6). The ACT reaction is activated by a partial charge transfer from Bz(+*) to Pr in the complex, and driven to completion by the formation of a covalent bond in the polymerized product. An alternative channel forms a stable association product (Bz.Pr)(+*), with an ACT/association product ratio of 60:40% that is independent of pressure and temperature. In contrast to the Bz(+*)/propene system, ACT polymerization is not observed in the Bz(+*)/ethylene (Et) system since charge transfer in the Bz(+*)(Et) complex is inefficient to activate the reaction. The roles of charge transfer in these complexes are verified by ab initio calculations. The overall reaction of Bz(+*) with Pr follows second-order kinetics with a rate constant of k (304 K) = 2.1 x 10(-12) cm(3) s(-1) and a negative temperature coefficient of k = aT(-5.9) (or an activation energy of -3 kcal/mol). The kinetic behavior is similar to sterically hindered reactions and suggests a [Bz(+*) (Pr)]* activated complex that proceeds to products through a low-entropy transition state. The temperature dependence shows that ACT reactions can reach a unit collision efficiency below 100 K, suggesting that ACT can initiate polymerization in cold astrochemical environments.
Behavioral Factors in Market User Interface Design (2013)

Despite the pervasiveness of electronic markets in our lives, only little is known about the role of user interfaces (UIs) in promoting good performance in market domains. How does the way we display market information to end-users, and the set of choices we oer, inuence economic eciency? In this paper, we introduce a new research agenda on \market user interface design. We take the domain of 3G bandwidth allocation as an illustrative example, and consider the design space of UIs in terms of varying the number of choices oered, xed vs. changing market prices, and situationdependent choice sets. The UI design induces a Markov decision process, the solution to which provides a gold standard against which user behavior is studied. We provide a systematic, empirical study of the eect of dierent UI design levers on user behavior and market performance, along with considerations of behavioral factors including loss aversion and position eects. Finally, we t a quantal-best response model to users’ actions and evaluate a behaviorally-optimized market user interface.
Proteomics of protein trafficking by in vivo tissue-specific labeling (2021)

Conventional approaches to identify secreted factors that regulate homeostasis are limited in their abilities to identify the tissues/cells of origin and destination. We established a platform to identify secreted protein trafficking between organs using an engineered biotin ligase (BirA*G3) that biotinylates, promiscuously, proteins in a subcellular compartment of one tissue. Subsequently, biotinylated proteins are affinity-enriched and identified from distal organs using quantitative mass spectrometry. Applying this approach in Drosophila, we identify 51 muscle-secreted proteins from heads and 269 fat body-secreted proteins from legs/muscles, including CG2145 (human ortholog ENDOU) that binds directly to muscles and promotes activity. In addition, in mice, we identify 291 serum proteins secreted from conditional BirA*G3 embryo stem cell-derived teratomas, including low-abundance proteins with hormonal properties. Our findings indicate that the communication network of secreted proteins is vast. This approach has broad potential across different model systems to identify cell-specific secretomes and mediators of interorgan communication in health or disease.
Speech Synthesis Data Collection for Visually Impaired Person (2014)

Crowdsourcing platforms provide attractive solutions for collecting speech synthesis data for visually impaired person. However, quality control problems remain because of low-quality volunteer workers. In this paper, we propose the design of a crowdsourcing system that allows us to devise quality control methods. We introduce four worker selection methods; preprocessing filtering, real-time filtering, post-processing filtering, and guess-processing filtering. These methods include a novel approach that utilizes a collaborative filtering technique in addition to a basic approach involving initial training or use of gold-standard data. These quality control methods improved the quality of collected speech synthesis data. Moreover, we have already collected 140,000 Japanese words from 500 million web data for speech synthesis data.
Application of illumination pupilgram control method with freeform illumination (2012)

Source Mask Optimization1 (SMO) is one of the most important techniques available for extending ArF immersion lithography. The combination of freeform source shape and complex mask pattern, determined by SMO, can extend the practical resolution of a lithography system. However, imaging with a small k1 factor (~0.3 or smaller) is very sensitive to many imaging parameters, such as illumination source shape error, lens aberration, process property, etc. As a result, the real source shape must be re-adjusted to realize the expected imaging performance as may be seen, for example, in an Optical Proximity Effect (OPE) curve. In this paper we present an illumination pupilgram re-adjustment method that can effectively control the various illumination parameters to get optimum imaging performance, which is required for the lithography process design. The modulation functions are called Zernike intensity/distortion modulations2. Since the pupilgram modulation is expressed by Zernike polynomials3, a high degree of pupilgram adjustment freedom is provided to the intelligent illuminator4 (freeform illumination) which can be effectively modeled in the optimization. Furthermore, the magnitude of each adjusting Zernike component can be restricted to prevent over modulation, which may affect imaging performance for various patterns on a mask. Furthermore, the linear impact of each term of Zernike modulation can allow us to use Zernike linear combination analysis to calculate imaging performance. Therefore, optimization using a large variety of illumination modulation terms may be possible with reasonable computation loads. The method is combined with an imaging simulator that includes resist models and optimization algorithms in pupilgram refinement software called "OPE Master". The software can take into account the scanner signature and various constraints so that the result of the optimization can be accurately realized on the scanner. The optimization can be performed based on rigorous imaging simulation and Zernike linear combination analysis, which is based on a precalculated Zernike linear sensitivity table.
Figure S4 from Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer (2023)

&lt;p&gt;CONSORT diagram of sample flow and sequencing success rates.&lt;/p&gt;
Composition Analysis and Pharmacological Activity of Avocado/Soybean Unsaponifiable Products Used in the Treatment of Osteoarthritis (2022)

<b>Objective:</b> Avocado/soybean unsaponifiables (ASUs) are commonly used to treat OA symptoms. However, there are many ASU mixtures on the market with differing compositions and pharmacological activities. This study aimed to compare the composition and pharmacological activity of seven commercially available ASU products on human osteoarthritis chondrocytes. <b>Methods:</b> The contents of the lipidic part of ASUs were characterized by gas chromatography analysis using a VARIAN 3400 chromatograph. The pharmacological activity of the ASU products was tested on human osteoarthritis chondrocytes cultured in alginate beads. Their effects were evaluated on aggrecan, interleukin (IL)-6 and -8, and matrix metalloproteases (MMP)-3 using immunoassays and on nitric oxide through measurement of nitrite <i>via</i> spectrometry. <b>Results:</b> PIASCLEDINE-ExpASU<sup>®</sup> showed a specific profile with the presence of chromatographic peaks corresponding to an alkyl furan fraction and alkyl triols. PIASCLEDINE-ExpASU<sup>®</sup>, Persemax, Insaponifiable 300, Arthrocen, and Arthocare contained quantifiable amounts of tocopherol, while tocopherol was undetectable in Avovida and Saponic. Squalene was found only in PIASCLEDINE-ExpASU<sup>®</sup>. The abundance of sterols varied depending on the product. PIASCLEDINE-ExpASU<sup>®</sup> was the most active of the tested ASU products in inhibiting nitric oxide, IL-6, and IL-8 production by chondrocytes. With the exception of Saponic and Persemax, all the ASU mixtures either slightly or significantly increased aggrecan production. MMP-3 levels were significantly decreased by Insaponifiable 300 and PIASCLEDINE-ExpASU<sup>®</sup> and significantly increased by Saponic. <b>Conclusion:</b> The composition of PIASCLEDINE-ExpASU<sup>®</sup> is different to that of the other evaluated ASU mixtures. This specific composition explains its better pharmacological activity, including the higher inhibitory effect on pro-inflammatory and pro-catabolic factors. Our findings are helpful in providing a basis for understanding the symptomatic effect of PIASCLEDINE-ExpASU<sup>®</sup> in patients with osteoarthritis.
A case of intoxication with tea made from Digitalis purpurea (2021)

We present the case of a 34-year-old woman with recurrent depressive disorder who ingested purple foxglove with suicidal intent. She bought a foxglove plant <i>(Digitalis purpurea)</i> over the internet and used all of its leaves to make a tea that she then drank over a period of a few hours. Seventeen hours later, she developed abdominal pain, emesis and bradycardia and was admitted via the emergency department to the intensive care unit for further treatment and monitoring. The plasma digoxin concentration measured 3.53 nmol/l (therapeutic reference range 0.77-1.50 nmol/l) 21 hours after ingestion of the tea. She remained heamodynamically and neurologically stable, was treated with antiemetics and simple analgesia and did not require digoxin-specific antibodies. Despite normal renal function, her plasma digoxin half-life was prolonged (estimated 76 h), reflecting the long half-life of the parent compound digitoxin which is the main cardiac glycoside in <i>Digitalis purpurea</i>. She was transferred to psychiatric care 48 h after admission. In this report, we compare this case to other similar cases, which to date have only been rarely reported in the literature.
ChemInform Abstract: PHOTOELEKTRONSPEKTREN VON MOLEKUELEN 4. MITT. IONISATIONSPOTENTIALE UND BLDG.‐WAERMEN EINIGER HYDRAZINE UND AMINE (1970)

Abstract Aus den Photoelektronspektren werden die Ionisationspotentiale der Hydrazine (I) und (II), der Aziridine (III) und der Amine (IV) bestimmt.
Programmable Polarization-Independent Electrooptically Matched Bandpass Filter in Ti:LiNbO<inf>3</inf> (2007)

A polarization-independent two-port electro-optically tunable bandpass filter with programmable spectral output in the 1530 nm wavelength regime with nearest side lobes -20 dB, 10 nm tuning range, and maximum required voltage 31.5 V is presented.
Effects of Ouabain on Blood Pressure Regulation in Rats (1986)

In order to test the hypothesis that a circulating inhibitor of the sodium-potassium ATPase pump may cause a concomitant rise in blood pressure and increased sodium excretion, we studied chronic effects of continuous infusion of ouabain, an inhibitor of sodium-potassium ATPase, for up to 6 days on systolic blood pressure and urinary sodium excretion in conscious rats. We also evaluated the effect of this substance in rats with hypertension induced by chronic infusion of norepinephrine. Continuous infusion of ouabain (1.2 mg/kg per day) into the jugular vein by an osmotic minipump did not induce any changes in systolic blood pressure and urinary sodium excretion in intact rats on regular diets. Furthermore it did not cause a change in systolic blood pressure in rats drinking 1% NaCl, and in unilaterally nephrectomized rats drinking 1% NaCl, when compared with vehicle-infused animals. When the same dose of ouabain was administered simultaneously with 1.8 mg/kg per day norepinephrine infused intraperitoneally by another osmotic minipump in conscious rats, systolic blood pressure rose on day 1 to only 129.3 +/- 2.8 mmHg compared with the rist to 145.0 +/- 2.0 mmHg when norepinephrine alone was infused (P less than 0.01). The antihypertensive effect of ouabain was sustained for the entire experimental period lasting for 6 days and was not associated with any changes in urinary sodium excretion. The administration of ouabain to rats made hypertensive by a 3-day infusion of norepinephrine, returned the blood pressure to control levels, and the antihypertensive effect was sustained throughout the experimental period lasting a further 3 days and was not associated with any changes in urinary sodium excretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Total synthesis of (-)-colletol (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (-)-colletolGary E. Keck and Jerry A. MurryCite this: J. Org. Chem. 1991, 56, 23, 6606–6611Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/jo00023a029https://doi.org/10.1021/jo00023a029research-articleACS PublicationsRequest reuse permissionsArticle Views1055Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Destruction and Reconstitution of Polyphospholipid Vesicles with Size Memory (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDestruction and Reconstitution of Polyphospholipid Vesicles with Size MemoryShinji Takeoka, Takeru Ohgushi, and Eishun TsuchidaCite this: Macromolecules 1995, 28, 23, 7660–7666Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://doi.org/10.1021/ma00127a011RIGHTS & PERMISSIONSArticle Views61Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Rapid Immunoassay Development using the U-PLEX® Assay Platform. (2017)

Abstract In the expanding field of biomarker research, methods to identify immunoassay reagents and optimize their use can be rate limiting for product development programs. Flexible tools that accelerate assay development, from antibody screening and selection to assay feasibility, can accelerate these programs. Here we demonstrate the use of the MSD® U-PLEX platform to conduct early assay development steps in parallel in a multiplex format. This resulted in rapid identification of a multiplexed panel of compatible assays. Unbiased pairwise screening of 59 antibodies was performed on MULTI-SPOT® U-PLEX plates using biotinylated capture antibodies and detection antibodies conjugated with SULFO-TAG™ label. Feasible antibody pairs were identified based on high signal and low background, then ranked using parameters such as dynamic range, sensitivity, specificity, sample recognition, and matrix tolerance. Within four weeks, two prototype immunoassays were developed and characterized. This screening time frame can range from days to weeks depending on the number of starting antibodies (typically 10–50) and the level of characterization required. Due to the flexible nature of the platform and the ability to mix and match reagents, the same conjugated reagents identified in screening were used to create and characterize multiplex assay panels. Parameters such as calibration curve, assay protocol, detection antibody concentration, and non-specific binding were characterized with up to ten assays simultaneously in a multiplex. In conclusion, we demonstrate the utility of a flexible assay development system that allows rapid identification and optimization of assays for stand-alone use or in combination with existing MSD assays.