gebhart/patrepeval huggingface dataset:
The Quiet Rebel: William Dean Howells as Social Commentator (1960)

Journal Article The Quiet Rebel: William Dean Howells as Social Commentator. By Robert L. Hough. (Lincoln: University of Nebraska Press, 1959. x + 137 pp. Notes and index. $4.00.) Get access Paul J. Carter Paul J. Carter University of Colorado Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 47, Issue 2, September 1960, Pages 340–342, https://doi.org/10.2307/1891739 Published: 01 September 1960
Are Inductive Current Transformers Performance Really Affected by Actual Distorted Network Conditions? An Experimental Case Study (2020)

The aim of this work is to assess whether actual distorted conditions of the network are really affecting the accuracy of inductive current transformers. The study started from the need to evaluate the accuracy performance of inductive current transformers in off-nominal conditions, and to improve the related standards. In fact, standards do not provide a uniform set of distorted waveforms to be applied on inductive or low-power instrument transformers. Moreover, there is no agreement yet, among the experts, about how to evaluate the uncertainty of the instrument transformer when the operating conditions are different from the rated ones. To this purpose, the authors collected currents from the power network and injected them into two off-the-shelf current transformers. Then, their accuracy performances have been evaluated by means of the well-known composite error index and an approximated version of it. The obtained results show that under realistic non-rated conditions of the network, the tested transformers show a very good behavior considering their nonlinear nature, arising the question in the title. A secondary result is that the use of the composite error should be more and more supported by the standards, considering its effectiveness in the accuracy evaluation of instrument transformers for measuring purposes.
The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells (2014)

The transcription factor NF-κB is central to inflammatory signaling and activation of innate and adaptive immune responses. Activation of the NF-κB pathway is tightly controlled by several negative feedback mechanisms, including A20, an ubiquitin-modifying enzyme encoded by the tnfaip3 gene. Mice with selective deletion of A20 in myeloid, dendritic, or B cells recapitulate some human inflammatory pathology. As we observed high expression of A20 transcripts in dysfunctional CD8 T cells in an autochthonous melanoma, we analyzed the role of A20 in regulation of CD8 T-cell functions, using mice in which A20 was selectively deleted in mature conventional T cells. These mice developed lymphadenopathy and some organ infiltration by T cells but no splenomegaly and no detectable pathology. A20-deleted CD8 T cells had increased sensitivity to antigen stimulation with production of large amounts of IL-2 and IFNγ, correlated with sustained nuclear expression of NF-κB components reticuloendotheliosis oncogene c-Rel and p65. Overexpression of A20 by retroviral transduction of CD8 T cells dampened their intratumor accumulation and antitumor activity. In contrast, relief from the A20 brake in NF-κB activation in adoptively transferred antitumor CD8 T cells led to improved control of melanoma growth. Tumor-infiltrating A20-deleted CD8 T cells had enhanced production of IFNγ and TNFα and reduced expression of the inhibitory receptor programmed cell death 1. As manipulation of A20 expression in CD8 T cells did not result in pathologic manifestations in the mice, we propose it as a candidate to be targeted to increase antitumor efficiency of adoptive T-cell immunotherapy.
Computational Fluid Dynamics and Doublet-Lattice Calculation of Unsteady Control Surface Aerodynamics (2001)

Accurate prediction of control surface aerodynamics has been a challenge since the dawn of aviation. Whereas this has been an important problem for many years, recent increases in the use of control surfaces for active control (load alleviation and e utter suppression ) have increased the importance of accurate steady and unsteady control surface aerodynamics. Because of the strong ine uence of viscosity on the pressures on a trailing-edge control surface, the aerodynamic theories based on the linear potential equation have had only marginal success in predicting control surface aerodynamics, and in practice, large corrections (based on wind-tunnel data ) are often required for acceptable accuracy. Recent advances in computing technology and unsteady aerodynamic codes based on the Navier ‐Stokes equation areallowing moreaccurate analysesto be performed. Unsteady aerodynamic calculations due to control surface oscillations are made using a linear potential code (N5K) and a Navier‐Stokes code (CFL3D.AE-BA version 4.1 ). The Navier‐Stokes calculations are performed in the time domain using an exponential pulse technique and are transformed to the frequency domain using Fourier transform. For low reduced-frequency cases, theNavier ‐Stokes calculations arecompared to the doublet-lattice method and to experiment, and the advantages of the nonlinear analysis are clearly demonstrated. Correlation between Navier ‐Stokes and doublet-lattice results is then studied for higher reduced frequencies.
SIMULTANEOUS PARALLEL REDUCTION ON SIMD MACHINES (1995)

Proper distribution of operations among parallel processors in a large scientific computation executed on a distributed-memory machine can significantly reduce the total computation time. In this paper, we propose an operation called simultaneous parallel reduction(SPR), that is amenable to such optimization. SPR performs reduction operations in parallel, each operation reducing a one-dimensional consecutive section of a distributed array. Each element of the distributed array is used as an operand to many reductions executed concurrently over the overlapping array's sections. SPR is distinct from a more commonly considered parallel reduction which concurrently evaluates a single reduction. In this paper we consider SPR on Single Instruction Multiple Data (SIMD) machines with different interconnection networks. We focus on SPR over sections whose size is not a power of 2 with the result shifted relative to the arguments. Several algorithms achieving some of the lower bounds on SPR complexity are presented under various assumptions about the properties of the binary operator of the reduction and of the communication cost of the target architectures.
MP69-10 PROGNOSTIC SIGNIFICANCE OF PSA AND TUMOR VOLUME AS A PREDICTOR FOR BCR IN PROSTATE CANCER WITH EXCLUSIVE APEX MARGIN INVOLVEMENT (2016)

METHODS: We identified 236 patients who underwent RT and/ or ablation therapy for prostate cancer and proceeded to SRP between 2000 and 2014. Among these 236 patients, 83 had available tumor maps from whole mount slides. We evaluated the detailed pathological characteristics of recurrent prostate cancer in these 83 patients.
3GPP MN-AR interface (2009)

This ID documents the interface between the Mobile Node and the
Mobility Access Gateway in the context of 3GPP Evolved Packet Core
networks. The main goal is to support the Netext working group in the
discussions on the MN to AR interface showing how RFC 5213 has been
deployed by other SDOs. This document has been inspired by
considerations expressed in [I-D.gundavelli-netext-extensions-
motivation].
Model analysis on the performance for an inertial aided FLL-assisted-PLL carrier-tracking loop in the presence of ionospheric scintillation (2007)

Ionospheric scintillation has a significant impact on the availability of Global Positioning System (GPS) and Wide Area Augmentation System (WAAS), especially when the GPS/WAAS receiver is dynamically stressed. An example of such a scenario would be an aircraft using WAAS to make an approach and landing. This study investigated the tolerable wideband interference level given various conditions of ionospheric scintillation. Two important criteria are used to determine the tolerable wideband interference level: the tracking threshold and the word error rate (WER) of the navigation data demodulation. An inertial aided FLL-assisted-PLL carrier-tracking loop is considered to be effective for increasing the receiver robustness to interference. This paper quantitatively gives the improvement using the inertial aided FLL-assisted-PLL and compares it to the generic PLL as well as inertial aided PLL carrier-tracking loops. Theoretical model analysis was performed for the above three tracking-loop configurations considering all possible error sources which can potentially degrade carrier-tracking loop performance. These errors include satellite/receiver clock dynamics, platform dynamics, platform vibrations, sensitivity of the receiver clock to acceleration, wideband interference, and ionospheric scintillation. The results showed that there is a 10 dB improvement in the minimum 0 / N C by using a FLL as a backup tracking loop when compared to the receiver with PLL used as the primary tracking loop only. However, satisfying the requirements of the WER limits the performance of this technique.
Mapping a multiplexed zoo of mRNA expression (2016)

In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which multiple target mRNAs are mapped in a single sample, are essential for studying regulatory interactions, but remain cumbersome in most model organisms. Programmable in situ amplifiers based on the mechanism of hybridization chain reaction (HCR) overcome this longstanding challenge by operating independently within a sample, enabling multiplexed experiments to be performed with an experimental timeline independent of the number of target mRNAs. To assist biologists working across a broad spectrum of organisms, we demonstrate multiplexed in situ HCR in diverse imaging settings: bacteria, whole-mount nematode larvae, whole-mount fruit fly embryos, whole-mount sea urchin embryos, whole-mount zebrafish larvae, whole-mount chicken embryos, whole-mount mouse embryos and formalin-fixed paraffin-embedded human tissue sections. In addition to straightforward multiplexing, in situ HCR enables deep sample penetration, high contrast and subcellular resolution, providing an incisive tool for the study of interlaced and overlapping expression patterns, with implications for research communities across the biological sciences.
ISIS Flooding Reduction (2018)

This document proposes an approach to flood ISIS link state protocol
data units on a topology that is a subgraph of the complete ISIS
topology per underline physical network, so that the amount of
flooding traffic in the network is greatly reduced, and it would
reduce convergence time with a more stable and optimized routing
environment. The approach can be applied to any network topology in a
single ISIS area.
DSP-based technique for power efficiency improvement in low-IF 5 GHz WLAN transmitter (2005)

This paper proposes a DSP based technique for power efficiency enhancement in a low-IF WLAN IEEE 802.11a transmitter architecture. This work combines a clipping function with an oversampling operation for reducing signal envelope variation. For that, an optimal oversampling factor was firstly chosen for a given input signal type. A clipped signal is then applied to a predistortion-based linearized power amplifier. The value of the clipping ratio is set so that the resulting overall transmitter error vector magnitude (EVM) meets the standard specifications. This allowed an important reduction of the power back-off that in its turn leads to a significant increase of the power added efficiency (PAE). Experiments that were performed using a 1-watt commercial solid state power amplifier demonstrated a relative power efficiency improvement of about 80 %.
Digital Fiber Nonlinearity Compensation: Toward 1-Tb/s transport (2014)

The world is connected by a core network of long-haul optical communication systems that link countries and continents, enabling long-distance phone calls, data-center communications, and the Internet. The demands on information rates have been constantly driven up by applications such as online gaming, high-definition video, and cloud computing. All over the world, end-user connection speeds are being increased by replacing conventional digital subscriber line (DSL) and asymmetric DSL (ADSL) with fiber to the home. Clearly, the capacity of the core network must also increase proportionally.
[The evaluation of smoking and alcohol consumption by university students in Gdańsk]. (2001)

Anonymous questionnaire examination were performed among 1585 students from eight universities in Gdańsk, including 664 men and 921 women from 17 to 48 (mean 21.4 +/- 2.26) years old. Alcohol was consumed by 1452 (91.61%) students, including 91.53% women and 91.72% men. Both men and women preferred beer, respectively, 73.7% and 50.6%. In three-stage AUDIT-test (alcohol drinking dangerous to health) including 716 (45.2%) students, most of them in stage A (81.6%); in stage B about 8.2% comprised while there were about 10.2% in stage C students. Alcohol consumption carried the lowest risk (stage A) among students of Medical University while corresponding risk was the highest among students of Maritime High School. Among respondents drinking alcohol dangerously to health there were significantly more persons who did drugs (73.7%). Students qualified to the AUDIT test smoked cigarettes significantly more often than the rest of the examined population. Smokers amounted to 399 (25.2%) students, including 224 (26.3%) women and 157 (23.6%) men. The difference in figures was statistically non-significant. Among smoking respondents the students of Fine Arts Academy constituted the majority, while those of Medical University and of University School of Physical Education were in minority. Catholic Priest Seminary respondents did not have the relevant experiences.
Fiber-coupled Fabry-Pérot notch filter combining in-plane axis, high speed MEMS tunability and large etching depth (2015)

Notch filters based on fiber-coupled Fabry-Pérot cavity are formed by a reflector placed in close proximity to a dielectric-coated end of an optical fiber. This kind of optical filters is easy to tailor for a given application because the external mirror has less mechanical and optical constraints. In this paper we present a fiber-coupled Fabry-Pérot filter based on dielectric-coated optical fiber inserted into a fiber groove facing a metallized micromirror, where the latter is driven by a high-speed MEMS actuator. The microsystem is fabricated using Deep Reactive Ion Etching (DRIE) technology on SOI wafer. The optical axis is in-plane and the components are self-aligned. The DRIE etching depth is 150 μm; chosen for improving the out-of-plane stiffness of the actuator and increasing the micromirror optical throughput. The MEMS actuator type is closing-gap while its quality factor is improved by slotting the fixed plate. The actuator, therefore, achieves a travel distance larger than 800 nm and has a resonance frequency of 90 kHz. The notch filter exhibits a free spectral range up to 100 nm and a notch rejection ratio of 20 dB around a wavelength of 1300 nm. The presented device provides low cost wafer level production of the filter.
Decision Directed Scheme for IQ Imbalance Compensation on OFCDM Direct Conversion Receiver (2006)

Recently, the direct conversion scheme has been actively investigated for the purpose of cost miniaturization and low power consumption of wireless receivers. IQ imbalance is one of the problems for the direct conversion receiver. In the case of OFCDM modulations, this IQ imbalance causes intercarrier interference (ICI) in the demodulated signals. In this paper, the decision directed scheme for IQ imbalance compensation is proposed. In the proposed scheme, the combination of received symbols which satisfies orthogonality conditions is used for compensation of IQ imbalance. Therefore, in addition to the pilot symbols, the received symbols can be used in order to improve the accuracy of the compensation matrix and BER can be reduced.
Tunability of space-time wave packet carrying tunable and dynamically changing OAM value (2022)

Space-time (ST) wave packets have gained much interest due to their dynamic optical properties. Such wave packets can be generated by synthesizing frequency comb lines, each having multiple complex-weighted spatial modes, to carry dynamically changing orbital angular momentum (OAM) values. Here, we investigate the tunability of such ST wave packets by varying the number of frequency comb lines and the combinations of spatial modes on each frequency. We experimentally generate and measure the wave packets with tunable OAM values from +1 to +6 or from +1 to +4 during a ∼5.2-ps period. We also investigate, in simulation, the temporal pulse width of the ST wave packet and the nonlinear variation of the OAM values. The simulation results show that: (i) a pulse width can be narrower for the ST wave packet carrying dynamically changing OAM values using more frequency lines; and (ii) the nonlinearly varying OAM value can result in different frequency chirps along the azimuthal direction at different time instants.
Intracellular distributions of mechanochemical proteins in cultured fibroblasts (1977)

We have used methods that have allowed simultaneous fluorescent staining of intracellular actin together with either myosin, filamin, or tubulin in normal rat kidney fibroblasts in monolayer culture. In the main portions of the cell body, the actin, myosin, and filamin are all present in two structures: in one, the three proteins are present in the same fiber bundles (stress fibers); in the other, there is a diffuse distribution of the three proteins. On portions of the cell periphery however-in the basal regions of microspikes, in ruffles, and in regions of cell-cell contact-actin and filamin are present, but myosin is severely depleted or absent. Microtubules are present in the cell body in a distribution independent of the stress fibers and are mostly absent from the cell periphery. Microspikes and ruffles are highly dynamic structures on the cell surface, and regions of cell-cell contact generally result from the association of ruffles on the two contacting cells. Therefore, the presence of filamin and actin but not myosin in these specialized regions on the cell surface, together with the recent demonstration [Wang, K. & Singer, S. J. (1977) Proc. Natl. Acad. Sci. USA 74, 2021-2025)] that pure filamin interacts with individual F-actin filaments in solution to form fiber bundles and sheet-like structures, suggest that in vivo filamin-actin interactions play an important role in the control of actin filament structure, in cell motility, and in the stabilization of cell-cell contacts.
7-Hydroxymitragynine is an Active Metabolite of Mitragynine and a Key Mediator of its Analgesic Effects (2019)

Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United States and concerns that kratom represents an uncontrolled drug with potential abuse liability, have highlighted the need for more careful study of its pharmacological activity. The major active alkaloid found in kratom, mitragynine, has been reported to have opioid agonist and analgesic activity in vitro and in animal models, consistent with the purported effects of kratom leaf in humans. However, preliminary research has provided some evidence that mitragynine and related compounds may act as atypical opioid agonists, inducing therapeutic effects such as analgesia, while limiting the negative side effects typical of classical opioids. Here we report evidence that an active metabolite plays an important role in mediating the analgesic effects of mitragynine. We find that mitragynine is converted in vitro in both mouse and human liver preparations to the much more potent mu-opioid receptor agonist 7-hydroxymitragynine, and that this conversion is mediated by cytochrome P450 3A isoforms. Further, we show that 7-hydroxymitragynine is formed from mitragynine in mice and that brain concentrations of this metabolite are sufficient to explain most or all of the opioid-receptor-mediated analgesic activity of mitragynine. At the same time, mitragynine is found in the brains of mice at very high concentrations relative to its opioid receptor binding affinity, suggesting that it does not directly activate opioid receptors. The results presented here provide a metabolism-dependent mechanism for the analgesic effects of mitragynine and clarify the importance of route of administration for determining the activity of this compound. Further, they raise important questions about the interpretation of existing data on mitragynine and highlight critical areas for further research in animals and humans.
High-pressure neutron study of the morphotropic lead-zirconate-titanate: Phase transitions in a two-phase system (2012)

The present study was dedicated to the classical piezoelectric, lead-zirconate-titanate ceramic with composition Pb(Zr0.54Ti0.46)O3 at the Zr-rich side of the morphotropic phase boundary at which two phases co-exists. The pressure-induced changes in the phase fractions were studied by high-pressure neutron powder diffraction technique up to 3 GPa and 773 K. The two co-existing phases were rhombohedral R3c and monoclinic Cm at room temperature and R3c and P4mm above 1 GPa and 400 K. The experiments show that pressure favors the R3c phase over the Cm and P4mm phases, whereas at elevated temperatures entropy favours the P4mm phase. At 1 GPa pressure, the transition to the cubic Pm3¯m phase occurred at around 600 K. Pressure lowers the Cm→P4mm transition temperature. The Cm phase was found to continuously transform to the P4mm phase with increasing pressure, which is inline with the usual notion that the hydrostatic pressure favours higher symmetry structures. At the same time, the phase fraction of the R3c phase was increasing, implying discontinuous Cm→R3c phase transition. This is in clear contrast to the polarization rotation model according to which the Cm would link the tetragonal and rhombohedral phases by being a phase in which the polarization would, more or less continuously, rotate from the tetragonal polarization direction to the rhombohedral direction. Pressure induces large changes in phase fractions contributing to the extrinsic piezoelectricity. The changes are not entirely reversible, as was revealed by noting that after high-pressure experiments the amount of rhombohedral phase was larger than initially, suggesting that on the Zr-rich side of the phase boundary the monoclinic phase is metastable. An important contribution to the intrinsic piezoelectricity was revealed: a large displacement of the B cations (Zr and Ti) with respect to the oxygen anions is induced by pressure.
First Principles Model of Electric and Magnetic Cable Braid Penetrations. (2019)

Abstract not provided.