gebhart/patrepeval huggingface dataset:
Persistent pollutants: focus on perfluorinated compounds and kidney (2019)

Further studies are required on the potential synergic negative effect of PFCs co-exposure with other pollutants as well as animal studies about the removal capacity of different haemodialysis membranes.
Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization (2009)

Intradermal immunization using microfabricated needles represents a potentially powerful technology, which can enhance immune responses and provide antigen sparing. Solid vaccine formulations, which can be coated onto microneedle patches suitable for simple administration, can also potentially offer improved shelf-life. However the approach is not fully compatible with many vaccine adjuvants including alum, the most common adjuvant used in the vaccine market globally. Here, we introduce a polyphosphazene immuno adjuvant as a biologically potent and synergistic constituent of microneedle-based intradermal immunization technology. Poly[di(carboxylatophenoxy)phosphazene], PCPP, functions both as a vaccine adjuvant and as a key microfabrication material. When used as part of an intradermal delivery system for hepatitis B surface antigen, PCPP demonstrates superior activity in pigs compared to intramascular administration and significant antigen sparing potential. It also accelerates the microneedle fabrication process and reduces its dependence on the use of surfactants. In this way, PCPP-coated microneedles may enable effective intradermal vaccination from an adjuvanted patch delivery system.
The Human Herpesviruses - An Interdisciplinary (1982)

the RES, and why, remains unclear. The first table, which is probably meant to clarify this point fails to do so, since it not only includes the poly- morphonuclear leucocytes as well as 'reticular cells of spleen, CNS, lymph- nodes and bone marrow', but also lists a series of cells, e.g. Kuppfer cells, which are considered to be 'specialized endothelial cells' belong- ing to the 'fixed' phagocytes. Neither the origin of these cells, nor the reason for listing them are given. With some exception one may read 'mono- nuclear phagocytes' for 'RE cells' throughout the book, since virtually nowhere are endothelial cells, reti- culum cells or other mesenchymal cells meant. In my opinion, Aschoff's command 'to apply the RES critically' (p. 94) is disobeyed. If we consider a system a group of cells with a common origin, morphology, function and other properties, the RES can no longer be regarded as a system. The mononuclear phagocyte system as proposed in 1969 (Bull. WHO 46:845, 1972) and updated several times since then, is to be preferred. Another problem is the lack of references in the text. In a textbook meant for students, this may not be a disadvantage, but this book cannot be recommended as such. Although each chapter is followed by a list of references, the reason each is included is unclear. Investigations mentioned in the text do not appear in that list, and many times observations made by unnamed investigators are not repre- sented in the list of references. The subject index is also unsatisfactory. More detailed criticism can be made of the various chapters. For instance, in the chapter on the bio- chemical aspects of phagocytic cells, the biochemistry of monocytes and macrophages is largely ignored in favour of polymorphonuclear leuco- cytes. In the chapter on alveolar macrophages, the discussion of their origin is incomplete and largely in- correct (p. 53). i enjoyed the chapter on the con- trol of hemostatic and thrombotic mechanisms. Although valuable infor- mation is given on fibronectin in this chapter and in the chapter on 'RES and cardiopulmonary functions', I must object to the statement that fibronectin is the sole opsonin and to a term like 'hypoopsonemia' for a state of low concentrations of circulating fibronectin. The editors intend this book 'for graduate students in the basic medical sciences as well as postdoctoral fellows and clinical residents, so that they can begin to appreciate the complexity of this RES system and its potential importance to biology and medicine'. I cannot recommend this book for these readers. J. w. rvl. VAN I)ER MEER
Post-Selection-Free Mode-Locked Two-Photon State for High-Dimensional Hyperentanglement Generation (2013)

We report realization of high-dimensional hyperentanglement in frequency and polarization from a postselection-free mode-locked two-photon state. Quantum-interference dips and revivals are observed with 97.8% visibility and a Bell inequality is violated in polarization.
Controlled Synthesis of Ag/Ag/C Hybrid Nanostructures and their Surface‐Enhanced Raman Scattering Properties (2011)

SERS them right: Ag/C nanoparticles (see figure; red line) and Ag/Ag/C nanoclusters (blue line) were synthesized as platforms for surface-enhanced Raman scattering (SERS). The results showed that the Ag/Ag/C nanoclusters led to great enhancement of the Raman signals for methyl benzenethiol molecules.
Interference diversity gain in frequency hopping GSM (2002)

Wideband random frequency hopping is one of the key properties of GSM in an evolution towards PCS (personal communication services). Random frequency hopping introduces diversity on the transmission link, which improves the performance. In this paper, the impact of interference diversity in GSM is analyzed by means of bit level simulations of the GSM full rate speech channel. The analysis shows that the gain of interference diversity is highly system load dependent. The interference diversity gain is most striking in a system with low channel utilization. These results, together with system level simulations of frequency hopping GSM, show that random frequency hopping has implications for frequency planning. They indicate that GSM systems with simple frequency planning can be designed without sacrificing the overall system quality.
The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate (2017)

Defects in the surfactant biosynthesis are associated with respiratory distress syndrome, commonly occurring in premature infants due to lung immaturity. However, interstitial lung diseases have also been observed in full-term infants with mutations in the SFTPC, SFTPB, NKX2-1, or ABCA3 genes, involved in the surfactant metabolism. Herein, we report a newborn baby with neonatal respiratory distress and diffuse lung disease caused by ABCA3 mutation. The baby died at 5 weeks of age after developing pulmonary hypertension. Genomic DNA was analyzed for four genes involved in surfactant metabolism out of which the c. 4545C>G (p.Tyr1515*) homozygous mutation in exon 29 of ABCA3 was identified which is one of the most frequent mutation causing lethal neonatal respiratory failure in a term neonate. This case study emphasizes the importance of raising awareness about this diagnosis in the clinical settings for fruitful outcomes in health-care delivery.
Depth profile analysis of helium in silicon with high-resolution elastic recoil detection analysis (2010)

Helium depth profiling in silicon was investigated by high-resolution elastic recoil detection analysis (HERDA) using a high-resolution Rutherford backscattering spectrometry system. A 0.7 μm Mylar film was installed in front of the detector of this system to eliminate the background signals originating from incident nitrogen ions scattered at the sample surface. This film successfully eliminated the background signals without the loss of helium signals or serious degradation of the depth resolution. The HERDA has several attractive features for helium depth profiling in silicon, including high sensitivity (detection limit of 1 at. % or less), excellent depth resolution (less than 1 nm), and good quantitative accuracy, giving it significant advantages over other surface analysis methods such as secondary ion mass spectrometry.
The Effectiveness of Different Functional Fibrinogen Polymerization Assays in Eliminating Platelet Contribution to Clot Strength in Thromboelastometry (2014)

FFPAs based solely on glycoprotein-IIb/IIIa inhibition, such as FFTEG or EXTEM-ABC, are less effective than cytochalasin D-based assays, such as FIBTEM or FIBTEM-S, at inhibiting the platelet component of clot strength. The FIBTEM PLUS assay, and the combination of FIBTEM and abciximab, sufficiently inhibits platelet contribution to clot elasticity. The combination of a glycoprotein-IIb/IIIa receptor blocker and cytochalasin D allows evaluation of functional fibrinogen polymerization without platelet "noise." In a clinical setting, the significance of potent platelet inhibition ensures a more accurate assessment of MCF and therefore the need for fibrinogen supplementation therapy. Further studies are necessary to investigate the application and impact of these tests in a clinical situation.
Long eye relief fundus camera and fixation target with partial correction of ocular longitudinal chromatic aberration (2018)

A combined 32° full field of view refractive fundus camera and fixation target with a -20 to +10 diopter sphere correction range is described and demonstrated. The optical setup partially corrects the average longitudinal chromatic aberration and spherical aberration of the human eye, while providing a long eye relief to allow integration with reflective adaptive optics ophthalmoscopes, as a viewfinder. The fundus camera operates with 940 nm light, using a maximum 2.9 mm diameter imaging pupil at the eye. The fixation target uses a light projector capable of delivering red, green and/or blue spatially and temporally modulated stimuli to the retina. The design and performance of each sub-system are discussed, and retinal imaging at various wavelengths is demonstrated.
Nitrite Reductase from Pseudomonas aeruginosa Released by Antimicrobial Agents and Complement Induces Interleukin-8 Production in Bronchial Epithelial Cells (1999)

We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of respiratory cells, including bronchial epithelial cells (K. Oishi et al. Infect. Immun. 65:2648-2655, 1997). In this report, we examined the mode of nitrite reductase (PNR) release from a serum-sensitive strain of live P. aeruginosa cells during in vitro treatment with four different antimicrobial agents or human complement. Bacterial killing of P. aeruginosa by antimicrobial agents induced PNR release and mediated IL-8 production in human bronchial epithelial (BET-1A) cells. Among these agents, imipenem demonstrated rapid killing of P. aeruginosa as well as rapid release of PNR and resulted in the highest IL-8 production. Complement-mediated killing of P. aeruginosa was also associated with PNR release and enhanced IL-8 production. The immunoprecipitates of the aliquots of bacterial culture containing imipenem or complement with anti-PNR immunoglobulin G (IgG) induced twofold-higher IL-8 production than did the immunoprecipitates of the aliquots of bacterial culture with a control IgG. These pieces of evidence confirmed that PNR released in the aliquots of bacterial culture was responsible for IL-8 production in the BET-1A cells. Furthermore, the culture supernatants of the BET-1A cells stimulated with aliquots of bacterial culture containing antimicrobial agents or complement similarly mediated neutrophil migration in vitro. These data support the possibility that a potent inducer of IL-8, PNR, could be released from P. aeruginosa after exposure to antimicrobial agents or complement and contributes to neutrophil migration in the airways during bronchopulmonary infections with P. aeruginosa.
Geometry-Based Compression of Plenoptic Point Clouds (2022)

Plenoptic point clouds (PPC) are novel data structures that represent the light from different viewing directions in order to provide a higher degree of realism to regular point clouds. This is achieved by associating each point to multiple colors instead of a single one. Here, we present a method to efficiently compress the attributes of a PPC, consisting of a Karhunen-Loève transform over the color attributes followed by multiple attribute coders with intra prediction capability. This compression scheme can be incorporated within the MPEG's geometry-based PCC (G-PCC) standard, using any of G-PCC's existing solutions for attribute coding. Compression performance assessment using PPCs of different spatial resolutions reveals competitive results in comparison to existing methods, such as RAHT-based or video-based PCC solutions. We believe our coder to be the new state of the art.
A new class of thienopyrimidine Src inhibitors demonstrates potent growth suppression of imatinib resistant Ba/F3 cells harboring a wide range of BCR-ABL mutations, including the CML relevant T315I (2007)

B238 Purpose: Next generation Abl and Src kinase inhibitors (including dasatinib, AP23464, and AMN107) have demonstrated potent activity against some clinically relevant BCR-ABL mutants that lead to imatinib resistance. Howewer, these compounds generally fail to suppress cells harboring some variants, including the T315I mutant, prompting us to investigate a new class of thienopyrimidine Src inhibitors as candidate agents to treat patients with imatinib resistant forms of cancer.  Experimental Procedures: Drug Dose Response (DDR) experiments were performed to evaluate the effectiveness and selectivity of two thienopyrimidine Src inhibitors for inhibiting the growth and survival of a panel of cell lines harboring BCR-ABL mutants associated with imatinib resistance. Specifically, we performed DDR analyses on a panel of Ba/F3 cell lines, including the parental cell line (engineered to express and depend on the native BCR-ABL protein), and 9 variant cell lines expressing specific BCR-ABL mutants (M244V, Y253F, Y253H, E255K, E255V, T315A, T315I, M351T, and F359V). As a control, we tested imatinib, which as expected showed significant inhibition of K562 cells (IC50=236.5 nM), native BCR-ABL expressing Ba/F3 cell line (IC50 = 391.6 nM), however, all other Ba/F3 variant lines with BCR-ABL mutants showed resistance (IC50>2000 nM).  Summary of findings: Two of the Src inhibitors tested, SMi813 and SMi829, showed potent inhibition of survival (IC50
Synthesis and Aromaticity of Benzene‐Fused Doubly N‐Confused Porphyrins (2020)

A bicyclo[2.2.2]octadiene(BCOD)-fused bis(dipyrromethane) derivative was reacted with methylal in the presence of trifluoroacetic acid followed by oxidation with chloranil to give a doubly N-confused phlorin derivative, which did not undergo the retro-Diels-Alder reaction extruding an ethylene molecule on heating. In contrast, a 7-tert-butoxybicyclo[2.2.1]heptadiene(7-BuOBCHD)-fused bis(dipyrromethane) yielded benzene-ring-fused doubly N-confused porphyrins by following similar reaction sequences.
Cardiac Evaluation in Normal Infants: The Clinical and Clinical Laboratory Differentiation Between Normal and Abnormal (1966)

This monograph was conceived as a comprehensive correlation of information helpful in distinguishing normal infants from those with cardiovascular problems. The first seven chapters are devoted to fetal cardiovascular physiology, neonatal cardiovascular physiology, evaluation of heart murmurs, cyanosis, heart rate and rhythm, and the roentgenographic appearance of the infant heart. The remaining two chapters, one third of the book, are devoted to differential diagnosis of specific problems. There are 29 illustrations, mostly electrocardiographic tracings, and a good bibliography. Little new information is presented. As might be predicted by the topic, simple crystallization of the facts is difficult, and development of a systematic approach to the problem is not completely satisfying. The author is quite naturally reduced to philosophical exposition. The book is disappointing. No sense of added diagnostic information or development of a diagnostic approach emerges. The philosophy is compounded by a distracting prolixity. It seems doubtful that pediatricians will
Waveguide InGaAs MSM Photodetector for Chip-Scale Optical Interconnects on III-V CMOS Photonics Platform (2013)

InGaAs MSM photodetectors monolithically integrated with InP waveguides on SiO2/Si are demonstrated using III-V CMOS photonics platform. 20-μm-long InGaAs PD exhibits high responsivity of &gt; 1.05 A/W and broadband operation, enabling chip-scale WDM optical interconnects.
Novel Imprint Cytological Classification for Small Pulmonary Adenocarcinoma Using Surgical Specimens: Comparison with the 8th Lung Cancer Staging System and Histopathological Classification (2020)

<b>Objectives</b>: Small-size lung lesions suspected of being cancer are now often being identified on computed tomography. Correspondingly, a new lung cancer staging system has been proposed by the International Association for the Study of Lung Cancer (IASLC), in which the T1 factor and adenocarcinoma are re-subclassified. Previously, we proposed an intraoperative cytological diagnosis and its classification of small-size lung adenocarcinoma, which correlated significantly with clinical malignancy, to be used for selecting the surgical strategy. In the current study, the correlation of our intraoperative cytological classification with the new 8<sup>th</sup> IASLC classification was investigated. <b>Materials and Methods</b>: A total of 139 consecutive small-size lung adenocarcinoma cases were surgically resected from 2000 to 2006 and included in this study. Intraoperative stump imprint cytology using these specimens was performed, and the cases were classified into 5 groups based on our classification. The cytological classification was compared with the IASLC classification and the WHO histopathological grading. <b>Results</b>: According to our classification, 32 patients were in Group I, 38 in Group II, 24 in Group III, 27 in Group IV, and 18 in Group V. Compared with the IASLC classification, most of Group I was pTis or pT1mi, and most of Group II was pT1mi or pT1a (p<0.001). There was also a significant relationship between lymph node metastasis and our cytological classification (p<0.001). The histological patterns according to the WHO classification also had a significant relationship with our classification (p<0.001). <b>Conclusion</b>: Our cytological classification correlated not only with the T classification, but also with the adenocarcinoma subclassification of the 8<sup>th</sup> IASLC classification.
Genesis of Emerald-Bearing Quartz Veins Associated With the Lened W-Skarn Mineralization, Northwest Territories, Canada (2017)

Emerald at the Lened occurrence in the western Northwest
Territories is hosted by quartz veins cutting skarn near the
Lened granite pluton and older Selwyn Basin strata. Using field
relationships, Ar-Ar dating, whole-rock geochemistry, stable
isotopes (O, H, C, and B), and mineral chemistry, the sources
of the emerald-forming fluids and chromophores have been
assessed; the results clearly show that the ca. 100 Ma (Ar-Ar
muscovite) Lened emerald occurrence is a Type I (igneous)
skarn-hosted emerald deposit related to the proximal ca. 100 Ma
(Ar-Ar biotite) Lened pluton. Beryllium and other incompatible
elements (i.e., W, Sn, Li, B, and F) in the emerald, vein
minerals, and surrounding skarn were derived during the
terminal stages of crystallization of the proximal Lened
pluton. Decarbonation during pyroxene-garnet skarn formation in
the host carbonate rocks probably caused local overpressuring
and fracturing that allowed ingress of magmatic-derived fluids
and formation of
quartz-calcite-beryl-scheelite-tourmaline-pyrite veins. The
delta B-11 values of accessory dravite in the emerald veins
averages -4.9 + 0.3 parts per thousand (1 sigma, n = 10), which
is compatible with a magmatic source, and the Al-Fe-Mg
composition is that of tourmaline formed in sedimentary
environments, with Mg likely derived from metasomatism of local
marine carbonates. The vein fluid was largely igneous in
origin, but the dominant emerald chromophore V (emerald vein =
avg. 1560 ppm V versus 75 ppm Cr) was mobilized by metasomatism
of V-rich sedimentary rocks (avg. 2000 ppm V) that underlie the
emerald occurrence.
Investigation of Bacterial Adhesion on Nanoparticle Filler-Reinforced Dental Composites after Different One-Step Finishing Timing Using a Constant-Depth Film Fermenter (2017)

This in vitro study evaluates the influence of application time of a one-step finishing system has on biofilm accumulation over nanoparticle filler-reinforced dental composites using a microcosm biofilm model in a constant depth film fermenter (CDFF). For that, sixty disk-shaped specimens (ø=5 mm × 2 mm thick) were made with nanoparticle filler reinforced dental composites (EsthetX™ and IPS Empress Direct). The specimens were manually polished with a finishing system (Enhance®) following the manufacturer’s instructions for 5, 15 and 30 seconds, while unpolished specimens were used as controls. Oral biofilm was formed on the discs, using human saliva as inoculum and daily subject to 8 pulses of 10% sucrose solution. The biofilm was collected to determine the counts of total microorganisms. Data were analyzed by ANOVA-Tukey tests (α=5%). Increased time application of the finishing system significantly affected biofilm formation for tested materials (p ≤ 0.05). Biofilm formation over the nanoparticle filler-reinforced dental composites was greatly reduced after 15 s of application. No additional significant reduction in biofilm was observed when the specimens were finished for 30 seconds. However, differences related to the tested nanoparticle filler-reinforced dental composites were not statistically significant. By incorporating a minimum 15 s-time protocol into their everyday practices, dentists can positively reduce biofilm formation on nanoparticle fillereinforced dental composites and contribute to the longterm esthetic and integrity these restorations.
Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment (2013)

Trientine treatment significantly improved cardiac function in diabetic rats with substantive LV impairment. These results implicate impaired copper regulation in the pathogenesis of impaired cardiac function caused by diabetic cardiomyopathy, and support ongoing studies of trientine treatment in patients with heart failure.
My Life with LIF: A Personal Account of Developing Laser-Induced Fluorescence (2012)

Laser-induced fluorescence (LIF) is a spectroscopic technique that involves the excitation of a molecular target by a beam of laser radiation followed by the detection of the subsequent emission of radiation from the target. LIF detection has several advantages over absorption spectroscopy. First, LIF has excellent detection sensitivity because a signal is observed against a dark background. Second, the emitted radiation can be collected at various angles with respect to the incoming laser beam, making it possible to obtain two- and three-dimensional images because the fluorescence is emitted in all directions. Third, by dispersing the fluorescence, it is also possible to learn about the transitions from the state excited to the various lower levels of the target species. Finally, because of the delay between the excitation and detection events, it is also possible to learn about what processes the excited target undergoes in the intervening time.