gebhart/patrepeval huggingface dataset:
A comparison of lenalidomide/dexamethasone versus cyclophosphamide/lenalidomide/dexamethasone versus cyclophosphamide/bortezomib/dexamethasone in newly diagnosed multiple myeloma (2011)

Novel agents are considered standard components of induction therapy for newly diagnosed patients with multiple myeloma. We retrospectively compared the results of three consecutive phase 2 clinical trials; RD (lenalidomide/dexamethasone, n=34), CRD (cyclophosphamide/lenalidomide/dexamethasone, n=53) and CyBorD (cyclophosphamide/bortezomib/dexamethasone, n=63) (N=150). Response rates after four cycles of treatment were: ≥near complete response (nCR), 12% vs. 2% vs. 41%, P<0·0001 and very good partial response or better, 35% vs. 30% vs. 65%, P=0·0003, respectively. With all cycles of therapy considered, ≥nCR was 35%, 15% and 41%, P=0·006. However, there is no evidence that one regimen produced superior progression-free survival (PFS) (median: 3·2 vs. 2·3 vs. 2·7years, P=0·11) or overall survival (3-year: 88% vs. 79% vs. 88%, P=0·23). Transplantation did not impact PFS (median: 2·7 vs. 2·3 years, P=0·41) but was associated with improved OS (3-year: 93% vs. 75%, P≤0·001). High genetic risk patients (n=40) had earlier relapse despite lenalidomide or bortezomib (median: 2·1 vs. 2·7years, P=0·45). Grade 3/4 toxicities were least with CyBorD while CRD had most toxicity. In conclusion, CyBorD demonstrated superior responses and less frequent serious toxicity but more neuropathy when compared to RD and CRD. Importantly, 80% of patients treated with modern therapeutic approaches are alive at 4years.
Electrochemical Observation of Ligand Effects on Oxygen Reduction at Ligand-Stabilized Pt Nanoparticle Electrocatalysts (2008)

We investigate the effect of triphenylphosphine triphosphonate, TPPTP, on the electrocatalytic activity for the oxygen reduction reaction (ORR) at ligand-stabilized Pt nanoparticles . The catalyst supported on Vulcan carbon (VC) adsorbs and desorbs oxygen +40 mV vs the potential for bare Pt nanoparticles supported on VC , as measured by cyclic voltammetry in Ar-saturated 0.1 M . The area-specific ORR activity of Pt in the catalyst is higher than that of , as measured by rotating disk electrode voltammetry. These results suggest that the TPPTP ligand weakens the bond, resulting in the observed kinetic enhancement of the ORR.
Advanced Data Structures for Improved Cyber Resilience and Awareness in Untrusted Environments: LDRD Report (2018)

This report summarizes the work performed under the project "Advanced Data Structures for Improved Cyber Resilience and Awareness in Untrusted Environments." The goal of the project was to design, analyze, and test new data structures for cybersecurity applications. We had two major thrusts: 1) using new/improved write-optimized data structures and/or algorithms to better man- age and analyze high-speed massive-volume cyberstreams, and 2) adding security features to data structures at minimum cost. Write optimization allows data structures to better use secondary memory to store and search a larger amount of useful information. Secondary memory is large compared to main memory, but data movement to and from secondary memory must be carefully managed to run quickly enough to keep up with fast streams. The first thrust included managing cyberstreams in parallel, both multi-threaded and distributed, and improving the benchmarking infrastructure for testing new streaming data structures. We considered both (near) real-time discovery of particular patterns, and improved logging for improved forensics. We considered two kinds of security-feature problem. The first was high-performance history- independent external-memory data structures. These provide certain protections to data if a disk is stolen. We also prove some trade-offs between speed and security in this setting. The second data-security problem is more secure data look-up in secret-shared data bases. This report summarizes the project's major accomplishments, with the background to under- stand these accomplishments. It gathers the abstracts and references for the six refereed publications that have appeared as part of this work. We summarize several accomplishments that will be submitted for publication. We then archive one piece of partial work that is not likely to be published in the near future: validation of history-independent data structure implementations.
Synthesis and biological evaluation of a novel 18F-labeled biotin derivative for (strept)avidin-based pretargeted diagnosis (2008)

A comprehensive investigation has been made of photoreactivation of UV damage in cells cultured from the fat-tailed marsupial mouse, Sminthopsis crassicaudata. Maximal photoreversal of the lethal effects of germicidal UV radiation was obtained by exposure of cells to intense fluorescent black light at 37 degrees C. Dose-reduction factors of approximately 2 were obtained. This phenomenon was shown to be a true photoreactive not a photoprotective effect. Attempts to photoreverse the lethal effects of UV light by using white fluorescent light, or black lights at lower temperatures, proved ineffectual. Photoreactivation with black light at 37 degrees C for 30 min effectively photoreversed UV-induced pyrimidine dimers and also substantially reduced the levels of UV-induced DNA-repair replication. Sunlight was also found to be an effective source of photoreactivating light. Although a reasonable correlation was found between the lethal effects of UV light and the number of pyrimidine dimers persisting unrepaired in cellular DNA, some experiments did suggest that either a small subclass of dimers or some type of non-dimer damage contributed significantly to overall lethality. Two of the effects induced by UV light could not, however, be reversed by black light. These were sister-chromatid exchanges and the inhibition of DNA synthesis. The conclusion was reached that either these effects reflect non-dimer (non-photoreactivable damage) or that, under appropriate growth conditions, some damage rapidly disrupts the DNA, say within a replicon, in a manner which cannot be reversed even when the primary lesion has been subsequently removed.
"Determinación de la Variación 1 que se Genera en la Resistencia a la Compresión cuando se Adiciona 10% de Limolita con un Curado bajo Agua al Cemento Portland Tipo I" (2008)

At the moment, the Portland’s cement is an indispensable material in all construction. Therefore, the construction industry has the necessity to discover new materials that involves natural compounds and improvements in the mechanical resistance. This study is based in the knowledge of the effect of the different percentages of siltstone at different cured days in one of the most important mechanical properties as is the compression resistance to have the opportunity to discover new resistant materials and so to give ground to useful construction materials with the most compression resistance. The development of this paper is based to make mechanical tests to compounds formed with Portland I Cement to different siltstone percentages and a different cured times to study the affectation of these values in the compression resistance. In addition this paper includes the study with a reference material (with 0% of additive) and with every cured conditions which allows the comparisons with the compounds that includes the additives.
<title>Performances of multiprocessor multidisk architectures for continuous media storage</title> (1996)

Multimedia interfaces increase the need for large image databases, capable of storing and reading streams of data with strict synchronicity and isochronicity requirements. In order to fulfill these requirements, we consider a parallel image server architecture which relies on arrays of intelligent disk nodes, each disk node being composed of one processor and one or more disks. This contribution analyzes through bottleneck performance evaluation and simulation the behavior of two multi-processor multi-disk architectures: a point-to-point architecture and a shared-bus architecture similar to current multiprocessor workstation architectures. We compare the two architectures on the basis of two multimedia algorithms: the compute-bound frame resizing by resampling and the data-bound disk-to-client stream transfer. The results suggest that the shared bus is a potential bottleneck despite its very high hardware throughput (400Mbytes/s) and that an architecture with addressable local memories located closely to their respective processors could partially remove this bottleneck. The point- to-point architecture is scalable and able to sustain high throughputs for simultaneous compute- bound and data-bound operations.
Three Patterns of Acetabular Deficiency Are Common in Young Adult Patients With Acetabular Dysplasia (2016)

Three patterns of acetabular deficiency commonly occur among young adult patients with mild, moderate, and severe acetabular dysplasia. These patterns include anterosuperior, global, and posterosuperior deficiency and are variably observed independent of femoral version. Recognition of these distinct morphologic subtypes is important for diagnostic and surgical treatment considerations in patients with acetabular dysplasia to optimize acetabular correction and avoid femoroacetabular impingement.
Oxidative addition reactions of the bridging amido complex Ir2[.mu.-NH(p-tolyl)]2(CO)4: x-ray crystal structure of the 16e-18e dimer Ir2(Me)(I)[.mu.-NH(p-tolyl)]2(CO)4.cntdot.0.25C6H14 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative addition reactions of the bridging amido complex Ir2[.mu.-NH(p-tolyl)]2(CO)4: x-ray crystal structure of the 16e-18e dimer Ir2(Me)(I)[.mu.-NH(p-tolyl)]2(CO)4.cntdot.0.25C6H14Manoj K. Kolel-Veetil, Arnold L. Rheingold, and Kazi J. AhmedCite this: Organometallics 1993, 12, 9, 3439–3446Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/om00033a014https://doi.org/10.1021/om00033a014research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Regioselective Bromination of Activated Aromatic Substrates with N‐ Bromosuccinimide over HZSM‐5. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Flow Cytometry Study of Cellular Immunity in Rhesus Monkeys after Experimental Infection with SARS CoV 2 Virus (2022)

Cellular immunity plays an important role in the pathogenesis and formation of protective immune defense against the SARS‑CoV‑2 virus. The aim of the work was to study the cellular immunity of rhesus monkeys applying flow cytometry after experimental infection with the SARS‑CoV‑2 virus. Materials and methods . Male rhesus monkeys were intranasally inoculated with the SARS‑CoV‑2 virus, Isolate B strain and hCoV-19/Russia/SP48-1226/2020 strain (abbreviated name U-2), at a dose of 5.0 lg PFU. Using flow cytometry, the levels of 21 populations/subpopulations of mononuclear cells in the peripheral blood of animals were determined before experimental infection with the pathogen and on day 14 after infection. SARS‑CoV‑2 coronavirus RNA was assessed using real-time polymerase chain reaction. Determination of the titer of virus-neutralizing antibodies to the SARS‑CoV‑2 virus in the blood sera of animals was conducted through neutralization test evaluating the ability to suppress negative colonies. Results and discussion . Infection with Isolate B strain culture has led to an increase in the relative content of total T-lymphocytes (p˂0.2), cytotoxic T-lymphocytes (p˂0.1), as well as monocytes expressing the early activation marker CD25 (p˂0.2). The decrease in levels has been observed for total B-lymphocytes (p˂0.2) and T-helper cells (p˂0.1). Infection with the U-2 strain culture revealed an increase in the relative content of monocytes expressing the early activation marker CD25 (p˂0.2). Thus, for the first time in the Russian Federation, flow cytometry was used to study the cellular immunity of rhesus monkeys before and after experimental infection with the SARS‑CoV‑2 virus. The obtained information can be used for studying the pathogenesis of SARS‑CoV‑2 infection, course, and outcome of the disease, and developing strategies for vaccination and treatment.
Vehicle classification using road side sensors and feature-free data smashing approach (2016)

The main contribution of this paper is a study of the applicability of data smashing - a recently proposed data mining method - for vehicle classification according to the “Nordic system for intelligent classification of vehicles” standard, using measurements of road surface vibrations and magnetic field disturbances caused by passing vehicles. The main advantage of the studied classification approach is that it, in contrast to the most of traditional machine learning algorithms, does not require the extraction of features from raw signals. The proposed classification approach was evaluated on a large dataset consisting of signals from 3074 vehicles. Hence, a good estimate of the actual classification rate was obtained. The performance was compared to the previously reported results on the same problem for logistic regression. Our results show the potential trade-off between classification accuracy and classification method's development efforts could be achieved.
Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish ( Carassius auratus ) (1999)

In the goldfish (Carassius auratus) the two endogenous forms of gonadotropin-releasing hormone (GnRH), namely chicken GnRH II ([His5, Trp7,Tyr8]GnRH) and salmon GnRH ([Trp7,Leu8]GnRH), stimulate the release of both gonadotropins and growth hormone from the pituitary. This control is thought to occur by means of the stimulation of distinct GnRH receptors. These receptors can be distinguished on the basis of differential gonadotropin and growth hormone releasing activities of naturally occurring GnRHs and GnRHs with variant amino acids in position 8. We have cloned the cDNAs of two GnRH receptors, GfA and GfB, from goldfish brain and pituitary. Although the receptors share 71% identity, there are marked differences in their ligand selectivity. Both receptors are expressed in the pituitary but are differentially expressed in the brain, ovary, and liver. Thus we have found and cloned two full-length cDNAs that appear to correspond to different forms of GnRH receptor, with distinct pharmacological characteristics and tissue distribution, in a single species.
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates (2018)

A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and via biophysical characterization of DNA binding), chemical tractability, and in vitro and in vivo stability of the compounds in this class eliminated a number of potential candidates, greatly reducing the complexity and resources required for conjugate preparation and evaluation. This effort yielded a potent, stable, and efficacious ADC, PF-06888667, consisting of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline- p-aminobenzyl alcohol- N, N-dimethylethylenediamine (AcLysValCit-PABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase.
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray Structures (2018)

Two interesting new X-ray structures of negative allosteric modulator (NAM) ligands for the mGlu<sub>5</sub> receptor, M-MPEP (3) and fenobam (4), are reported. The new structures show how the binding of the ligands induces different receptor water channel conformations to previously published structures. The structure of fenobam, where a urea replaces the acetylenic linker in M-MPEP and mavoglurant, reveals a binding mode where the ligand is rotated by 180° compared to a previously proposed docking model. The need for multiple ligand structures for accurate GPCR structure-based drug design is demonstrated by the different growing vectors identified for the head groups of M-MPEP and mavoglurant and by the unexpected water-mediated receptor interactions of a new chemotype represented by fenobam. The implications of the new structures for ligand design are discussed, with extensive analysis of the energetics of the water networks of both pseudoapo and bound structures providing a new design strategy for allosteric modulators.
Characterization of a Unique MutantlysEGene, Originating fromCorynebacterium glutamicum, Encoding a Product That InducesL-Lysine Production inMethylophilus methylotrophus (2006)

lysE24 is an allele of lysE encoding an L-lysine exporter of Corynebacterium glutamicum. The mutant gene is able to induce L-lysine production in Methylophilus methylotrophus. Although lysE24 has a mutation in the middle of lysE that results in chain termination, the entire lysE locus, including the region downstream of the short open reading frame, is necessary for L-lysine production. We propose that separate polypeptides are synthesized from the lysE24 locus due to reinitiation of translation utilizing an existing start codon beyond the site of the frameshift, and present evidence that translational coupling is required to form the functional lysE24 product. In addition, expression of lysE24 induces L-lysine production in another methylotroph, Methylobacillus glycogenes. These data suggest that the lysE24 product is a split protein and that this curious feature might be a structure necessary for its functioning in certain obligate gram-negative methylotrophs.
Protein expression changes associated with radiation‐induced neoplastic progression of human prostate epithelial cells (1997)

Carcinogenic progression in most epithelial systems is a multistep process and presents as numerous (un)stable intermediate stages prior to the development of a fully malignant phenotype. Recently, we reported the neoplastic transformation of an SV40 immortalized, neonatal human prostate epithelial cell line (267B1) by multiple exposures to X-rays [1, 2]. The parental 267B1 cells acquired anchorage-independence and exhibited morphological transformation following exposure to two consecutive doses of 2 Gy. Exposure of either the parental 267B1 cells or the anchorage-independent derivatives (F3-SAC) to a total dose of 30 Gy of X-rays yielded tumorigenic transformants (267B1-XR and 267B1-SXR, respectively). All of these radiation-treated derivatives (F3-SAC, 267B1-XR, and 267B1-SXR) were characterized by reduced cell size and poorly organized actin stress fibers [2, 3]. The present study examines the protein expression changes associated with cytoskeletal alterations during the different steps of neoplastic progression induced by X-rays in the in vitro human prostate cell system. This analysis was achieved by using the high resolving power of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) in the 267B1, F3-SAC, 267B1-XR, and 267B1-SXR cells. We report changes in the expression of gelsolin in the partially transformed, anchorage-independent, nontumorigenic (F3-SAC) cells and a progressive loss of expression of tropomyosin isoforms (TM-1 and TM-3), and myosin light chain-2 (MLC-2) in the tumorigenic (267B1-XR; 267B1-SXR) cells, respectively. In contrast, our results demonstrate that the levels of the small GTP-binding protein Rho-A, an active participant in the actin stress fiber organization, are not altered during neoplastic progression of these 267B1 cells. Thus the changes in synthesis of gelsolin, tropomyosins, and MLC-2 provide a rationale for the alterations in the actin stress fiber formation and reduction in cell size during the exposure of prostate epithelial cells to multiple doses of X-rays.
Pd–H Species on Electrode Stabilized by Solvent Co-Adsorption: Observation by Operando IR Spectroscopy (2022)

On-top hydrogen on a Pd cathode (Pd–H) was observed for the first time by operando infrared (IR) spectroscopy at 2030 cm–1, being stabilized by co-adsorbed solvent (n-alkane) molecules. A proton-exchange membrane (PEM) reactor with Pt/C (anode) and Pd/C (cathode) catalysts was modified to transmit an IR beam for operando observation. Pd–H species was observed when (1) H+ was supplied to the cathodic chamber through the PEM, (2) solvent was flowed at the cathode, and (3) an appropriate bias was applied to the cathode. Because atomic H on Pd surfaces interacts with multiple Pd atoms, on-top Pd–H is proposed to be stabilized by co-adsorbed solvent molecules. Spectra of the solvent were deformed when Pd–H species were present: the peak intensity increased and nonfundamental bands at 2800–2500 cm–1 became pronounced. The intensification of these bands was caused by resonance with free-electron absorption bands in the IR region.
Correction: Direct synthesis of the organic and Ge free Al containing BOG zeolite (ITQ-47) and its application for transformation of biomass derived molecules (2020)

Correction for ‘Direct synthesis of the organic and Ge free Al containing BOG zeolite (ITQ-47) and its application for transformation of biomass derived molecules’ by Qintong Huang <italic>et al.</italic>, <italic>Chem. Sci.</italic>, 2020, DOI: 10.1039/d0sc04044d.