gebhart/patrepeval huggingface dataset:
Tissue factor pathway inhibitor in thrombosis and beyond: role of heparin (2004)

Tissue factor (TF) plays a crucial role in the pathogenesis of thrombosis, angiogenesis and inflammatory disorders, and the inhibition of this membrane protein thus provides a unique therapeutic approach for the prophylaxis and/or treatment of various diseases. In the past few years, TF pathway inhibitor (TRPI), the only endogenous inhibitor of the TF/FVIIa complex, has been characterized biochemically and pharmacologically. Studies in patients have demonstrated that both TF and TFPI may be indicators for the course and the outcome of cardiovascular and other diseases. Based on experimental and clinical data, TFPI may become an important drug or target for several clinical indications. Tissue factor pathway inhibitor is expected to inhibit the development of postinjury intimal hyperplasia and thrombolic occlusion in atherosclerotic vessels, as well as to be effective in acute coronary syndromes such as unstable angina and myocardial infarction. Of special interest is the inhibition of TF-mediated processes in sepsis and disseminated intravascular coagulation. At present, clinical studies with TFPI are rather limited, so the clinical potential of the drug cannot be property assessed. However, TFPI and its variants are expected to undergo further development and to find indications in various clinical states.
Change of copper(II) cation coordination in H-ZSM-5 channels upon the sorption of n-hexane and xenon: ESR spectroscopic evidence (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChange of copper(II) cation coordination in H-ZSM-5 channels upon the sorption of n-hexane and xenon: ESR spectroscopic evidenceA. V. Kucherov and A. A. SlinkinCite this: J. Phys. Chem. 1989, 93, 2, 864–867Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/j100339a063https://doi.org/10.1021/j100339a063research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Histone Modifications at Human Enhancers Reflect Global Cell-Type-Specific Gene Expression (2009)

Gene enhancers on the map The relative role of promoters, enhancers and other regulatory DNA elements in determining cell-type-specific gene expression is poorly understood. Now a chromatin-immunoprecipitation-based microarray (ChIP-chip) method has been used to generate maps of histone modifications at promoters and enhancers in several different human cell lines. The modification patterns at promoters are found to be largely invariant between cell types, whereas the patterns at most enhancers are specific to a single cell type and correlate with cell-type-specific gene expression.
ChemInform Abstract: Maximum Common Binding Modes (MCBM): Consensus Docking Scoring Using Multiple Ligand Information and Interaction Fingerprints. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Miniemulsion polymerization as a versatile tool for the synthesis of functionalized polymers (2010)

The miniemulsion technique is a particular case in the family of heterophase polymerizations, which allows the formation of functionalized polymers by polymerization or modification of polymers in stable nanodroplets. We present here an overview of the different polymer syntheses within the miniemulsion droplets as reported in the literature, and of the current trends in the field.
CDMA transmitter filtering for cellular overlay systems (2000)

In this paper, the overlay of a code-division multiple-access (CDMA) cellular system in a frequency band which is already providing service to a narrow-band cellular system is investigated. The motivation for this study is to demonstrate the potential of CDMA overlay as an efficient method for making a long-term transition from narrow-band cellular to CDMA cellular. For the single cell case, it was shown by Rainbolt and Miller (see IEEE J. Select. Areas Commun., vol.16, p.1756-64, 1998) that interference caused to the narrow-band system by even a lightly-loaded CDMA system is significant, a problem which can be greatly alleviated through the use of notch filtering in the CDMA transmitters to avoid active narrow-band users. Similar conclusions will be reached in this paper for the cellular case. The effects of notching on CDMA performance will be looked at in detail, and it will be shown that the notching is less of a problem than is the narrow-band interference inherent in overlay systems.
Picosecond Photoconductivity in Trans-Polyacetylene (1986)

Transient photoinduced absorption ( δα ) measurements (1) have been useful for studying the generation and characteristics of nonlinear excitations in polyacetylene. Here we focus on the transport properties of these excitations as revealed through studies of the transient photoconductivity, (2) σ p (t), measured using the Auston switch techniques (3) The switch consisted of a 50 Ω microstrip transmission line with a narrow gap (0.2 mm) on which a thin polymer sample was grown. The excitations were produced by uniformly illuminating the sample with 20 ps dye laser pulses (1 μJ/pulse) at 2.1 eV. The overall rise time in our measurements of σ p (t) is ~ 50 ps. Fig. 1 shows σ p (t) at a bias voltage of 300 V. The fast rise is followed by (approximately exponential) decay with τ ~ 300 ps which is the same magnitude as the rate of decay of δα (t). This indicates that mobile charged soliton excitations are produced within picoseconds, consistent with the Su-Schrieffer mechanism (4) , and that the decay of photocurrent is primarily due to decay of the number of charge carriers. The magnitude of σ p at 50 ps is about 0.3 S/cm for a flux of 10 15 cm −2 per pulse, an increase of about six orders of magnitude over the dark σ at room temperature.
Phase alignment of multiple surface coil data for reduced bandwidth and reconstruction requirements in volumetric MRI applications (2002)

Multiple element surface coils, or "phased array" multicoils, are often used volumetrically in magnetic resonance imaging (MRI) around a region of interest, such as the pelvis, head, abdomen or thorax to increase the image signal-to-noise ratio (S/N) when compared to the single channel "built-in" birdcage body coil. For applications which require high bandwidth such as echo-planar imaging or which perform continuous image acquisition such as real-time, or which acquire data with high temporal and spatial resolution such as 3D phase contrast and time-resolved 3D, the additional S/N gained from using multiple element surface coils is often critical for attaining adequate image quality. However, using the standard "sum of squares" technique can pose significant temporal limitations to the reconstruction, or pose significant demands on the available memory size, especially as requirements for reduced image acquisition time and improved spatial resolution increase. The authors show that multicoil phase alignment allows decreased technical requirements compared to the standard "sum of squares" method, while providing substantially improved S/N performance over a volumetric body coil.
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist (2016)

This article describes the application of Contour to the design and discovery of a novel, potent, orally efficacious liver X receptor β (LXRβ) agonist (17). Contour technology is a structure-based drug design platform that generates molecules using a context perceptive growth algorithm guided by a contact sensitive scoring function. The growth engine uses binding site perception and programmable growth capability to create drug-like molecules by assembling fragments that naturally complement hydrophilic and hydrophobic features of the protein binding site. Starting with a crystal structure of LXRβ and a docked 2-(methylsulfonyl)benzyl alcohol fragment (6), Contour was used to design agonists containing a piperazine core. Compound 17 binds to LXRβ with high affinity and to LXRα to a lesser extent, and induces the expression of LXR target genes in vitro and in vivo. This molecule served as a starting point for further optimization and generation of a candidate which is currently in human clinical trials for treating atopic dermatitis.
Production Of Ground State Atomic Oxygen In A Multifactor Stress Environment (1988)

A system for the production of ground state atomic oxygen, 0(3P), has been constructed and tested. Prime importance has been given to the use of a generation method in which the 0-atom flux could be accurately characterized with respect to both the exact identity and the absolute flux of the 0-atom species produced. Additionally, the system has been designed to permit multi-factor stress studies of test samples while they are being exposed to the 0-atom flux. A modular system of construction has been used for maximum flexibility in order to facilitate rapid changes in the experimental setup. 0(3P), atoms are produced by the well-known reaction of nitrogen atoms with nitric oxide to yield 0(<sup>3</sup>P) and N<sub>2</sub>. The reactions occurring are chemiluminescent and the reaction of N-atoms with NO is &apos;titrated&apos; so that the number of oxygen atoms produced can be calculated from the measured flow rate of NO at the stoichio-metric end-point of the reaction. With all of the NO exactly consumed, the gas stream contains only helium carrier gas, a known concentration of oxygen atoms, and chemically unreactive N2. By means of a suitable excitation and detection system, the resonance fluorescence of O(<sup>3</sup>P) is monitored. This continuous but relative measure of 0-atom concentration is then calibrated from the absolute value of the 0-atom concentra-tion, as previously described, to provide a continuous measure of the absolute concentration of atomic oxygen at any desired location in the system. Stress factors which can be applied include UV light (4000-2000 A at 50 suns intensity), temperature (ambient to 700 K), and electrical potential (0-5) kV).
Inter-cell interference management in OFDMA TDD downlink using sounding/silencing protocol (2011)

Modern cellular communication systems are based on frequency reuse 1. Although reuse 1 promises high peak data rates and significantly simplified network planning, the cell edge or cell overlap areas suffer from excessive inter-cell interference. In this work we address interference management for downlink part of these systems. Part of the radio resources is primarily reserved for protected access of vulnerable users. The protected access is based on a novel sounding/silencing protocol that takes advantage of instantaneous signal to interference plus noise ratio prediction and has power to silence strong interferers with low priority. The accompanied signaling scheme is developed for time division duplex systems. Our results in an indoor scenario with partly overlapping closed subscriber groups show that even with realistic control signal reception model the proportion of zero throughput users can be reduced by more than 50%.
Curcumin Intake Affects miRNA Signature in Murine Melanoma with mmu-miR-205-5p Most Significantly Altered (2013)

Melanoma is the most aggressive form of skin cancer with estimated 48,000 deaths per year worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties. Accordingly, dietary intake of this compound may be suitable for melanoma prevention. However, how this compound affects basic cellular mechanisms in developing melanoma still remains elusive. Therefore, the aim of this study was to investigate for the first time the impact of oral curcumin administration on the miRNA signature of engrafting melanoma. For this purpose, the effects of a 4% curcumin diet were tested on melanoma, which were established by injection of murine B78H1 cells in the flank of C57BL/6 mice. Curcumin diet or standard chow (control) was administered two weeks prior to injection of tumor cells until termination of the experiment. High throughput chip-based array analysis was deployed to detect alterations in the miRNA signature of the tumors. Curcumin treatment significantly reduced the growth of the flank tumors. Furthermore the miRNA expression signature in tumors was substantially altered by curcumin intake with mmu-miR-205-5p over 100 times higher expressed when compared to controls. The expression levels of identified key miRNAs in the tumor samples were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). A comparable expression pattern of these miRNAs was also detected in other curcumin-treated melanoma cell lines under in vitro conditions. Putative targets of curcumin-induced up-regulated miRNAs were enriched in 'o-glycan biosynthesis', 'endoplasmatic reticulum protein processing' and different cancer-related pathways. Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were significantly down-regulated in curcumin-treated tumors. These findings demonstrate a profound alteration of the miRNA expression signature in engrafting curcumin-treated melanoma with mmu-miR-205-5p being up-regulated most significantly.
Cu-catalyzed debrominative cyanation of gem-dibromoolefins: a facile access to α,β-unsaturated nitriles (2015)

An efficient catalytic route for the synthesis of α,β-unsaturated nitriles from easily accessible gem-dibromoolefins has been developed. The method utilized inexpensive reagents such as Cu2O as a catalyst, L-proline as a ligand and NaCN as a cyanide source to afford α,β-unsaturated nitriles in high yields (62-86%). A deuterium exchange study has shown that one of the bromide atoms of gem-dibromoolefins exchanges with cyanide while the other with a deuterium atom.
Supplementary Fig. 4 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors (2023)

&lt;p&gt;Supplementary Fig. 4 NEAT1 counts are reduced in formalin-fixed paraffin-embedded (FFPE) tissues compared to freshfrozen tissues.&lt;/p&gt;
Effects of ion concentration on refractive indices of fluids measured by the minimum deviation technique (2008)

Abstract The prism minimum deviation technique has been used to measure the fluid dependence of refractive indices. Fluids with varying ion concentration (0 to 1.0 M) and varying protein concentration (0.01‐10 mg/ml) have been examined and the measurements show that these parameters influence the refractive index values. Also it is shown by simulations that it is important to take the change of refractive index of the fluid into account when evaluating insitu protein adsorption measurements. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A digitally assisted baseband filter with 9MHz bandwidth and 0.3 dB IQ mismatch for a WLAN receiver chain (2009)

We describe the design of a fifth order opamp-RC filter in a 65nm digital CMOS process. Designed for a WLAN receiver chain, the baseband filter has a bandwidth of 9MHz and features extensive use of digital hardware to correct for analog imperfections and thereby relaxing area and power requirements. Measurements show a 24 dB adjacent channel attenuation and an out-of-band IIP3 of 33 dBm. The complete filter consumes 9.5mA from a 1.3V supply and occupies an area of 0.46mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
ChemInform Abstract: Further Synthetic Studies on the Conversion of Alcohols into Phenylthio Ethers. (1990)

Abstract The substitution of the hydroxyl function for the phenylsulfenyl group in sterically‐hindered alcohols such as (I) is achieved using diphenyl disulfide (II) in the presence of tri‐n‐butylphosphine.
Empirical Effects of Dynamic Human-Body Blockage in 60 GHz\n Communications (2018)

The millimeter wave (mmWave) bands and other high frequencies above 6~GHz\nhave emerged as a central component of Fifth-Generation (5G) cellular standards\nto deliver high data rates and ultra-low latency. A key challenge in these\nbands is blockage from obstacles, including the human body. In addition to the\nreduced coverage, blockage can result in highly intermittent links where the\nsignal quality varies significantly with motion of obstacles in the\nenvironment. The blockages have widespread consequences throughout the protocol\nstack including beam tracking, link adaptation, cell selection, handover and\ncongestion control. Accurately modeling these blockage dynamics is therefore\ncritical for the development and evaluation of potential mmWave systems. In\nthis work, we present a novel spatial dynamic channel sounding system based on\nphased array transmitters and receivers operating at 60 GHz. Importantly, the\nsounder can measure multiple directions rapidly at high speed to provide\ndetailed spatial dynamic measurements of complex scenarios. The system is\ndemonstrated in an indoor home-entertainment type setting with multiple moving\nblockers. Preliminary results are presented on analyzing this data with a\ndiscussion of the open issues towards developing statistical dynamic models.\n
Compatibility between Polycarboxylate and Viscosity-Modifying Admixtures in Cement Pastes (2012)

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Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal Cells (2014)

The transcription factor SOX9 is believed to be the master regulator of chondrogenesis. SOX8 is another SOX group E transcription factor with a high degree of homology to SOX9. Here, we demonstrate that SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. Knockdown of SOX9 reduced the expression of SOX8, COL2A1, and a range of other chondrogenic molecules. SOX8 knockdown reduced the expression of a large number of overlapping chondrogenic molecules, but not SOX9. Neither siSOX9 nor siSOX8 altered expression of the hypertrophic marker gene COL10A1. siSOX9, but not siSOX8 led to upregulation of hypertrophy associated genes MMP13 and ALPL. Transfection of synthetic SOX5, 6, and 9 mRNA trio upregulated SOX8, COL2A1, and ACAN, but not COL10A1 mRNA. Replacement of synthetic SOX9 by SOX8 in the SOX trio showed similar but lower chondrogenic effect. We conclude that SOX8 expression is regulated by SOX9, and that both together with SOX5 and SOX6 are required as a SOX quartet for transcription of COL2A1 and a large number of other chondrogenic molecules. Neither SOX8 nor SOX9 affect COL10A1 expression, but SOX9 inhibits chondrocyte hypertrophy through inhibition of MMP13 and ALPL expression.
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa (1995)

A novel gene encoding an aminoglycoside 3-N-acetyltransferase, which confers resistance to gentamicin, astromicin, and sisomicin, was cloned from Pseudomonas aeruginosa Stone 130. Its sequence was determined and found to show considerable similarity to an aac(3)-I gene previously cloned from R plasmids from Enterobacter, Pseudomonas, and Serratia spp. We have designated the genes from the R plasmids and this work aac(3)-Ia and aac(3)-Ib, respectively. The two aac(3)-I genes share 74% nucleotide identity, and their deduced protein products are 88% similar. These data suggest that the genes derive from a common ancestor. Homology between the flanking sequences of both aac(3)-I genes and other resistance determinants known to reside in integron environments was also observed. Intragenic probes specific for either aac(3)-Ia or aac(3)-Ib were used in hybridization studies with a series of gentamicin-, astromicin-, and sisomicin-resistant clinical isolates. Of 59 clinical isolates tested, no isolates hybridized with both probes, 30 (51%) hybridized with the aac(3)-Ia probe, 12 (20%) hybridized with the aac(3)-Ib probe, and 17 (29%) did not hybridize with either probe. These data suggest the existence of at least one other aac(3)-I gene.
Characterization of S centers generated by thermal degradation in SiO2 on (100)Si (2002)

The structural degradation of thermal SiO2 on (100)Si under isochronal vacuum annealing in the range Tan=950 °C–1250 °C was monitored by electron spin resonance (ESR) in terms of point defect creation, including Eγ′, Eδ′, EX and the elusive predominant degradation-center S. Depth profiling after heating at 1200 °C shows that the S centers predominantly reside near the oxide borders, generally in anticorrelation with the Eγ′ distribution. The resulting anisotropic demagnetization effect has enabled inference of the S center susceptibility. As to the nature of the S center, an observed weak hyperfine structure may comply with the S center being of the type SinO3−n≡Si⋅ either the single n=1 or a mix of both the n=1,2 variants.
Correlation between somatosensory evoked potentials and neuronal ischemic changes following middle cerebral artery occlusion. (1986)

In an attempt to determine the usefulness of evoked potentials as a measure of focal cerebral ischemia, we examined somatosensory evoked potentials (SEP's) and morphological neuronal changes in cats following unilateral middle cerebral artery (MCA) occlusion. Fifteen adult cats underwent transorbital occlusion of the MCA under halothane anesthesia. In seven cats the ipsilateral SEP's were abolished after middle cerebral artery occlusion, and did not show any recovery after 6 hours. The same seven cats showed the greatest area of moderate and severe ischemic neuronal changes, ranging from 21 to 64% (mean 39 +/- 14%) of the total ipsilateral cortical area. The remaining eight cats showed a complete flattening or decreased amplitude of the SEP after occlusion, but demonstrated a considerable recovery in the amplitude of the primary cortical potential during the six hours of the study. All these cats had ischemic areas of less than 15% (mean 9 +/- 3%) of the total ipsilateral cortex. These results demonstrate that the disappearance of the SEP and their failure to recover correlate with the extent and degree of histological cerebral ischemia.