gebhart/patrepeval huggingface dataset:
Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations (2023)

Pathogenic <i>Acanthamoeba</i> produce keratitis and fatal granulomatous amoebic encephalitis. Treatment remains problematic and often ineffective, suggesting the need for the discovery of novel compounds. For the first time, here we evaluated the effects of the anticancer drugs Irosustat and STX140 alone, as well as their nanoformulations, against <i>A. castellanii</i> via amoebicidal, excystment, cytopathogenicity, and cytotoxicity assays. Nanoformulations of the compounds were successfully synthesized with high encapsulation efficiency of 94% and 82% for Irosustat and STX140, respectively. Nanoparticles formed were spherical in shape and had a unimodal narrow particle size distribution, mean of 145 and 244 nm with a polydispersity index of 0.3, and surface charge of -14 and -15 mV, respectively. Irosustat and STX140 exhibited a biphasic release profile with almost 100% drug released after 48 h. Notably, Irosustat significantly inhibited <i>A. castellanii</i> viability and amoebae-mediated cytopathogenicity and inhibited the phenotypic transformation of amoebae cysts into the trophozoite form, however their nanoformulations depicted limited effects against amoebae but exhibited minimal cytotoxicity when tested against human cells using lactate dehydrogenase release assays. Accordingly, both compounds have potential for further studies, with the hope of discovering novel anti-<i>Acanthamoeba</i> compounds, and potentially developing targeted therapy against infections of the central nervous system.
Phase I clinical trial of antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of advanced pleural mesothelioma. (2010)

e17518 Background: SS1P is a recombinant immunotoxin, composed of an antimesothelin Fv fused to a 38 kDa fragment of Pseudomonas exotoxin A, targeting mesothelin, a cell surface glycoprotein that is highly expressed in many cancers including malignant mesothelioma (MM). The safety and maximum tolerated dose (MTD) of SS1P was established in phase I clinical trials and the MTD was 45 μ g/kg every other day × 3 doses. Based on preclinical studies that show remarkable synergy when SS1P is given with chemotherapy we initiated a clinical trial of SS1P with pemetrexed (P) and cisplatin (C) for frontline treatment of pleural MM. Methods: Eligible patients (pts) had received no prior treatment, had stage III / IV disease, ECOG PS 0-2, and good organ function. Pts received P 500 mg/m2; C 75 mg/m2 on day 1 every 3 weeks for 6 cycles. SS1P was administered in a dose escalating manner as: 25 μ g/kg; 35 μ g/kg; 45 μ g/kg and 55 μ g/kg on days 1, 3 and 5 of cycle 1 and 2. CT scan was performed every 2 cycles and every 3 months after completion of treatment and tumor response was evaluated using the modified RECIST criteria for mesothelioma. Results: Twelve pts (11 males, 1 female) have been treated so far. Five were treated at SS1P dose of 25 μ g/kg; 3 at 35 μ g/kg; 3 at 45 μ g/kg and 1 at 55 μ g/kg. Two pts treated at 25 μ g/kg withdrew after only 1 cycle and this cohort was expanded to 5 pts. One pt treated at 55μ g/kg had Grade 3 fatigue that was considered a DLT. Adverse events that were possibly or probably related to SS1P included Grade 3 hypoalbuminemia (3 pts) and pain (2 pts) and Grade 2 toxicities of hypoalbuminemia (5 pt), edema (3 pt), pain (2 pt) and fatigue (6 pt). Of the 10 evaluable pts, 5 had partial response (lasting 10 mo; 8+ mo; 5 mo; 5+ mo; 4+ mo), 2 had stable disease (lasting 18+ mo; 4 mo) and 3 had progressive disease. All three patients treated at SS1P dose level of 45μ g/kg had partial response. Conclusions: SS1P given in combination with P and C is well tolerated and clinical benefit was noted in 7 of 10 evaluable pts (5 partial responses and 2 stable disease). Dose escalation at the 55 μ g/kg dose level is ongoing, to be followed by cohort expansion at the MTD. No significant financial relationships to disclose.
3DBodyTex: Textured 3D Body Dataset (2018)

In this paper, a dataset, named 3DBodyTex, of static 3D body scans with high-quality texture information is presented along with a fully automatic method for body model fitting to a 3D scan. 3D shape modelling is a fundamental area of computer vision that has a wide range of applications in the industry. It is becoming even more important as 3D sensing technologies are entering consumer devices such as smartphones. As the main output of these sensors is the 3D shape, many methods rely on this information alone. The 3D shape information is, however, very high dimensional and leads to models that must handle many degrees of freedom from limited information. Coupling texture and 3D shape alleviates this burden, as the texture of 3D objects is complementary to their shape. Unfortunately, high-quality texture content is lacking from commonly available datasets, and in particular in datasets of 3D body scans. The proposed 3DBodyTex dataset aims to fill this gap with hundreds of high-quality 3D body scans with high-resolution texture. Moreover, a novel fully automatic pipeline to fit a body model to a 3D scan is proposed. It includes a robust 3D landmark estimator that takes advantage of the high-resolution texture of 3DBodyTex. The pipeline is applied to the scans, and the results are reported and discussed, showcasing the diversity of the features in the dataset.
Deuterium isotope effects on 13C chemical shifts of intramolecularly hydrogen‐bonded olefins (1995)

Abstract A series of intramolecularly hydrogen‐bonded enamines, enols and enethiols with ester carbonylic, ketonic carbonylic, thioester carbonylic, nitro and sulphoxide acceptors were investigated to obtain 13 C chemical shifts and deuterium isotope effects. Results from 33 new compounds and six remeasurements are compared with already existing data. An important aim was to show that isotope effects on chemical shifts are useful descriptors of hydrogen‐bonded systems and not only a parameter proportional to the 13 C chemical shifts. Substituent effects were studied and the donors and acceptors ranked according to their abilities to support hydrogen bonding. Steric effects strengthen the hydrogen bonding in cyclic five‐membered β‐diketones. Plots of two‐bond [ 2 ΔC(OD)] vs. four‐bond isotope effects [ 4 ΔC(OD)] show that 4 ΔC(OD) increases with increasing hydrogen bond strength and that large deviations from this relationship can be an indicator of tautomerism.
A Case of Hashimoto's Thyroiditis Associated with Renal Tubular Acidosis, Sjögren Syndrome and Empty Sella Syndrome (1992)

This report describes a 48-year old female patient with Hashimoto's thyroiditis, distal-type renal tubular acidosis (d-RTA), Sjögren syndrome (SjS), and empty sella syndrome (ESS). She has been receiving replacement of thyroxine for Hashimoto's thyroiditis since 1967. She felt muscle weakness and numbness in the extremities and was found to have low serum potassium (2.9 mEq/l) in 1987. Since then she has been administrated potassium chloride orally. She was admitted to our hospital because of recurrence of muscle weakness and numbness of the extremities in November 1990. Laboratory examination revealed that her serum levels of antimicrosomal antibody and anti-thyroglobulin antibody were highly positive (MCHA: x 2(10) x 100, and TGHA: x 100). Furthermore, she was revealed to have 1) d-RTA by oral tolerance tests with the administration of NH4Cl and NaHCO3, 2) SjS by Schirmer test and sialography, and 3) ESS by computed tomography and magnetic resonance imaging examinations of the pituitary. Association of Hashimoto's thyroiditis, d-RTA, SjS and ESS in this case may possibly be caused by common autoimmune mechanism.
A Mobile Transient Internet Architecture (2006)

This paper describes a new architecture for transient mobile networks destined to merge existing and future network architectures, communication implementations and protocol operations by introducing a new paradigm to data delivery and identification. The main goal of our research is to enable seamless end-to-end communication between mobile and stationary devices across multiple networks and through multiple communication environments. The architecture establishes a set of infrastructure components and protocols that set the ground for a Persistent Identification Network (PIN). The basis for the operation of PIN is an identification space consisting of unique location independent identifiers similar to the ones implemented in the Handle system. Persistent Identifiers are used to identify and locate Digital Entities which can include devices, services, users and even traffic. The architecture establishes a primary connection independent logical structure that can operate over conventional networks or more advanced peer-to-peer aggregation networks. Communication is based on routing pools and novel protocols for routing data across several abstraction levels of the network, regardless of the end-points' current association and state...
Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma.Identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity (1977)

A case of adult ganglioneuroma-pheochromocytoma with an associated watery diarrhea syndrome is reported. High levels of vasoactive intestinal peptide (VIP) were found in preoperative serum and in tumor tissue. The serum VIP levels fell to normal, and the watery diarrhea syndrome completely ceased following removal of the tumor. In addition to containing VIP, the tumor was rich in catecholamines, and calcitonin. Peptide hormone-containing extracts and catecholamine extracts from the tumor both activated the adenyl cyclase system and increased lipolytic activity in a preparation of isolated rat fat cells. The findings in this patient further link VIP with neural crest tissues, and suggest the importance of determining catecholamine levels in patients with the watery diarrhea syndrome.
From bench to bedside with advanced confocal microendoscope (2010)

The authors have successfully demonstrated 3-D high-resolution real-time in vivo imaging by the miniature MEMS-scanner based DAC (dual-axes confocal) probes in both form-factors (10 and 5-mm diameter) by acquiring reflectance and fluorescence images. From the obtained high quality images, the DAC microscope shows great potential to substantially enhance clinical imaging practice by permitting sub-surface 3-D in vivo real-time imaging. When coupled with fluorescence markers targeted against a variety of diseases, the microscope will enable on-table-management with in vivo real-time optical biopsy for early and accurate detection of cancer resection.
Sickle Cell transgenic mice demonstrate a pro‐thrombogenic phenotype (2009)

In this study we investigated the mechanisms involved in thrombus formation in sickle cell disease (SCD) because SCD patients are more susceptible to thrombotic events, with unknown reason. Thrombosis was induced using the light/dye method in cerebral venules and arterioles of wild‐type (WT:C57Bl/6), sickle cell transgenic (SCD; βs) and WT/βs chimeric (positive control) mice (1). Flow cessation time was recorded. Thrombus formation was reduced by 50% in SCD mice vs. WT in venules and arterioles, but not observed in chimeric mice. The clinical implication of anti‐coagulant therapy was investigated, using Hirudin and anti‐thrombin III (AT3) inhibitor. Hirudin increased thrombus formation in SCD mice, but only in WT venules, suggesting a possible heightened sensitivity in SCD microvasculature. The AT3 inhibitor increased flow cessation in all vessels of WT and SCD mice, implicating the importance of all coagulation pathways. This study further supports the growing evidence for a pro‐inflammatory and pro‐thrombogenic microcirculation in SCD mice, in particular the notion that SCD promotes thrombus formation. Understanding the susceptibility and pathways involved in thrombogenic situations that occur in SCD, it may lead to the identification of potential therapeutic targets in this painful and life‐threatening disease. Supported by the BBSRC 1. Wood, K. et al. AJPHCP. 2004.
Potent DNA Strand Annealing Mediated by the T7 Single‐Stranded DNA Binding Protein gp2.5 (2017)

Single‐stranded DNA binding proteins are ubiquitous in all domains of life and play essential roles in DNA replication, recombination, and repair. Bacteriophage T7 encodes a single‐stranded DNA binding protein, gp2.5, which is crucial for coordinating the synthesis of leading and lagging DNA strands. In addition to its role in DNA replication, T7 gp2.5 displays a potent homologous DNA strand annealing activity, which is necessary for genetic recombination. Gp2.5 enhances the annealing of DNA strands orders of magnitude over the spontaneous rate, and is considerably more efficient compared to other recombination proteins. The annealing of complimentary strands by gp2.5 is strictly specific for DNA. While the annealing reaction is somewhat tolerant to internal mismatches, it is very permissive to internal, unpaired loops. Here we provide a model for the mechanism of gp2.5‐mediated homologous strand annealing and explore its applicability in oligonucleotide‐mediated gene modification and the formation of higher‐order DNA structures in vitro .
GeFighters: an Experiment for Gesture-based Interaction Analysis in a Fighting Game (2006)

This paper presents GeFighters, a 3D fighting game that supports gesture based interaction. This application has been used to test and analyze gesture interaction in the context of games that need short and reliable response times. Some inherent aspects of the application have been analyzed, like the impact that interaction causes on frame renderization and response time related to the control of game characters. In order to implement the desired interaction, an input devices management platform, named CIDA, has been used.
Reduction of Magnetic Resonance Imaging-related Heating in Deep Brain Stimulation Leads Using a Lead Management Device (2005)

Small, concentric loops placed around the burr hole seem to reduce MRI-related heating for these implants. Although the mechanism is still not fully understood, a device such as that used in the present study could permit a wider range of clinical scanning sequences to be used at 1.5 and 3 T in patients with DBS implants, in addition to increasing the margin of safety for the patient.
Stress and Temperature Effects on Ultrasonic Properties in Cross-Linked and High Density Polyethylene (2005)

Cross-linked polyethylene is widely used in the manufacturing of rotationally molded tanks for the agriculture, petroleum, and chemical industries. These tanks are exposed to a number of environmental effects, which can lead to material degradation. Measuring ultrasonic wave speed change in the outer wall of the tank is a method that shows promise for evaluating the ultraviolet (UV) degradation effects. In order to evaluate the UV effects in the field, however, the effect of stress and temperature on the wave speed first must be established. A series of tests was performed to establish the ultrasonic properties in cross-linked as well as linear polyethylene at a range of temperatures from −6°Cto44°C (22°Fto112°F). The change is linear, as expected. For the stress tests, the velocity decreased with tension, also as expected. Tests were performed from approximately 689kPato9.6MPa(100to1400psi). Results from these tests were incorporated into the overall algorithm used for evaluating tank degradation.
Characterization of a factor from human ovarian follicular fluid which stimulates Leydig cell testosterone production (1988)

Abstract. A factor from human ovarian follicular fluid (hFF) has been characterized which stimulates testosterone production of human, rat, mouse and hamster Leydig cells. hFF was obtained from women participating in an in vitro fertilization programme. Basal and hCG stimulated testosterone production of rat interstitial cells, and Percoll purified Leydig cells were significantly stimulated by hFF. The steroidogenic response of the cells was 3–5 fold higher than that obtained after stimulation with maximal doses of hCG. A serum pool from the same patients was found to be about 30 times less potent than hFF in stimulating steroidogenesis. The stimulatory activity was retained after precipitation with ammonium sulphate and dialysis. Precipitation with ethanol, ether and acetone resulted in a partial loss of activity, whereas extraction with charcoal or heating at 100°C for 10 min resulted in significant loss of activity. When hFF was fractionated by gel chromatography, the stimulatory activity was eluted in a molecular weight region between 30 and 50 kD. The stimulatory factor was further purified by chromatofocusing and was eluted as a homogeneous peak with an isoelectric point between 8.8 and 9.5. The SDS-PAGE analysis of these fractions, however, revealed that the active substance was not homogeneous. The purified factor was immunologically distinct from hCG and hLH. These studies demonstrate for the first time the presence of a factor in the hFF which may potentiate the action of LH in the ovary.
161: Normative Values of the Short Forms of the UDI and IIQ in a Population-Based Sample (2004)

from a published report of an international cost survey (Chandhoke
Synthetic, Structural, and Electrical Aspects of Molecular and Polymeric Selenium and Tellurium Materials (1984)

Abstract The physical and structural concepts concerning organochalcogen-based anisotropic organic metals are summarized, and the rationales which motivate synthetic activity in new selenium and tellurium materials are presented. An overview of our approach to new aromatic molecular and polymeric materials involving direct thermal reaction of new alkali chalcogenide reagents with unactivated aromatic halides is given, and recent applications to the synthesis of tetraselenonaphth-alene (TSeN) and new transition metal diselenolenes based on o-benzenediselenolate (bds) are noted. The crystal and molecular structures of TSeN and (nC4Hg)4N+ Ni(bds)2′ have been determined, as well as their electronic absorption and electron spin resonance spectra and cyclic voltammetric behavior. The reaction of cis-dichloroethylene and sodium diselenide leads to a polymer to which the repeat sequence ←Se-CH=CH-CH-CR-Se→ is assigned, based on elemental analysis and infrared spectrum.
Using Cement Plugs in Soft Tissue Infection and Osteomyelitis (2014)

Operative foot and ankle osteomyelitis is challenging for orthopedic surgeons because of the area’s unique anatomy, high trauma incidence, local and systemic disease effects, and often limited space. Standard treatment includes aggressive operative debridement with local and systemic antibiotic administration to control infection. Dead space management is critical yet technically demanding. The authors report a modified antibiotic cement bead therapy technique in which antibiotic sticks, minnows, and mushroom-shaped plugs are used to strike a balance between the stability of the load-bearing unit and radical removal of infection to preserve a functional foot. Three cases are presented.
Influence of fixation distance on peripheral fusional areas and peripheral hysteresis (2001)

The size of sensory fusional and refusional areas of seven observers were measured for three fixation distances and eight retinal eccentricities. Results show that sensory fusion is affected by fixation distance and retinal eccentricity.
Diffractive optical elements fabricated by laser direct writing and other techniques (1993)

Four different thin DOE pattern generation techniques used at National Optics Institute (NOI) are discussed and compared: laser direct writing in photoresist, microlithography with e-beam masks, holographic recording, and laser assisted microfabrication. NOI special equipment used for each technique is described and applications are presented.
Improved interfacial bonding in cellulosic biocomposites with humins-based furanic resins (2015)

International audience
Ferroelectric tunability: from characterization to telecomunication application (2012)

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Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy (2021)

The Orsay Proton therapy Center (ICPO) has a long history of intracranial radiotherapy using both double scattering (DS) and pencil beam scanning (PBS) techniques, and is actively investigating a promising modality of spatially fractionated radiotherapy using proton minibeams (pMBRT). This work provides a comprehensive comparison of the organ-specific secondary neutron dose due to each of these treatment modalities, assessed using Monte Carlo (MC) algorithms and measurements. A MC model of a universal nozzle was benchmarked by comparing the neutron ambient dose equivalent,<i>H</i>*(10), in the gantry room with measurements obtained using a WENDI-II counter. The secondary neutron dose was evaluated for clinically relevant intracranial treatments of patients of different ages, in which secondary neutron doses were scored in anthropomorphic phantoms merged with the patients' images. The MC calculated<i>H</i>*(10) values showed a reasonable agreement with the measurements and followed the expected tendency, in which PBS yields the lowest dose, followed by pMBRT and DS. Our results for intracranial treatments show that pMBRT yielded a higher secondary neutron dose for organs closer to the target volume, while organs situated furthest from the target volume received a greater quantity of neutrons from the passive scattering beam line. To the best of our knowledge, this is the first study to compare MC secondary neutron dose estimates in clinical treatments between these various proton therapy modalities and to realistically quantify the secondary neutron dose contribution of clinical pMBRT treatments. The method established in this study will enable epidemiological studies of the long-term effects of intracranial treatments at ICPO, notably radiation-induced second malignancies.
A detailed study of the volatile components of Plectranthus asirensis of Saudi Arabian origin (2016)

Essential oil composition of Plectranthus asirensis grown in Saudi Arabia was chemically analysed for the first time by various gas chromatography techniques (GC-MS, GC-FID, Co-GC, LRI determination and database and literature searches) using two different stationary phase columns (polar and nonpolar). This analysis led to the characterisation of a total of 124 components representing 98.5% of the total oil composition. The results revealed that P. asirensis oil was mainly dominated by monoterpenoids (90.7%) in which most representative constituents were thymol (66.0 ± 0.36%), γ-terpinene (14.0 ± 0.18%), p-cymene (5.2 ± 0.06%) and β-caryophyllene (3.0 ± 0.03%). It is worth mentioning here that this is the first report on the phytochemical constituents of P. asirensis.