gebhart/patrepeval huggingface dataset:
VisImpact: business impact visualization (2005)

Business Intelligence (BI) deals with transforming raw business data into valuable information for making decisions. The goal is to improve the operation and use of large-scale, complex information systems. A number of automated BI techniques are available. These methods, however, have to be supported by user interaction to make successful business decisions. In this paper, we present a new technique for interactive business intelligence based on visualization technology, called VisImpact. The basic idea of the VisImpact technique is to visually display the relationships between the important business operation parameters and the distribution of the process flow. We have applied VisImpact in the areas of business contract analysis, business operation analysis, and fraud analysis, to show the power of the VisImpact technique for finding process flows, patterns, and trends, and for a quick identification of exceptions (outliers). Our interactive VisImpact system provides the means for an instant drilldown to a transaction record level which allows observing the evolution of business dynamics.
Phosphorus-containing polyurethanes based on bisphenol-AF, prepared byN-alkylation (1996)

Phosphorus-containing polyurethanes (PU-P) based on bisphenol-AF were synthesized by N-alkylation in a two-step process. First, the polymer was metalated with sodium hydride; then the prepared urethane polyanion was treated with diethyl 2-bromoethyl phosphate. IR spectra exhibited characteristic absorptions at 1303 cm−1 (PO stretch), 1015 cm−1 (CH stretch), 1646 cm−1 (CO stretch), 1231 cm−1 (CNH), and 1053 cm−1 (COOC stretch). In the 1H-NMR spectrum of the maximum substituted PU-P, the signal of the urethane proton (NHCOO) at 9.87 ppm virtually disappeared as expected; new signals appeared at 1.20–1.24 ppm (POCH2CH3) and 3.79 ppm (POCH2CH3). Physical and thermal properties of the N-alkylated polymer were also investigated with differential scanning calorimetry (DSC), solubility, X-ray diffraction, thermogravimetric analysis (TGA), limiting oxygen index (LOI), and reduced viscosity. DSC analysis showed that Tg values were decreased from 81 to 43°C. The reduced viscosities of the PU-Ps were observed in the range of 0.23–0.18 dL g−1. The results of TGA revealed that the thermal stability was decreased, because the phosphorus moiety in the PUs is readily dissociated thermally. The PU-Ps exhibited enhanced fire resistance because phosphorus simultaneously promoted carbonization of the polymer and inhibited combustion. The X-ray diffraction patterns of the PU-Ps showed that with increasing phosphorus content, the degree of crystallinity of the PUs decreased. N-alkylated PUs are soluble, not only in polar solvents such as N,N-dimethylformamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, and H2SO4, but also in less polar solvents such as phenol, toluene, THF, and trichloroethylene. © 1996 John Wiley & Sons, Inc.
Performance Comparison of MLSE-Based Receivers in a 1000 km Transmission Link under Fast SOP Variations (2010)

This paper aims at comparing the tolerance to fast SOP variations of two MLSE-based receivers. Descriptions of the emulation device and measurement method are given. The results show that the receiver architecture impacts the performance.
Dissection and Comparative Anatomy of the Origins of Replication of Lambdoid Phages (1979)

Bacteriophage λ DNA replication begins at a unique origin region located near position 40,000 on the 50,000-bp-long λ DNA molecule. A map of this region is shown in Figure 1. Initiation leads to formation of a pair of replication forks which proceed in both directions away from the origin region.
Supplementary Figure Legend from Enhanced Effector Responses in Activated CD8<sup>+</sup> T Cells Deficient in Diacylglycerol Kinases (2023)

&lt;p&gt;PDF file - 77K&lt;/p&gt;
Early Respiratory Infection is Associated with Reduced Spirometry in Children with Cystic Fibrosis (2014)

The onset of lung disease in infancy, specifically the occurrence of lower respiratory tract infection, is associated with low lung function in young children with cystic fibrosis. Deficits in lung function measured in infancy persist into childhood, emphasizing the need for targeted therapeutic interventions in infancy to maximize functional outcomes later in life.
15‐3: Invited Paper : Liquid Crystal Technologies Towards Realising a Field Sequential Colour (FSC) Display (2016)

In modern liquid crystal displays the use of RGB filters significantly reduces the maximum possible light efficiency. We present a number of technologies that would enable field sequential driving (FSC) to be realized. A FSC backlight system would increase efficiency and reduce power consumption.
Authorship change form from Immunotherapy of Ipilimumab and Nivolumab in Patients with Advanced Neuroendocrine Tumors: A Subgroup Analysis of the CA209-538 Clinical Trial for Rare Cancers (2023)

&lt;p&gt;Authorship change form&lt;/p&gt;
Outbreak of Pseudomonas aeruginosa via multiple organ transplantation from a common donor (2002)

Objective: Non myeloablative conditioning regimen (NMCR) for AHSCT have been developed to reduce procedure-related toxicity.The aim of this approache is to extend indications of AHSCT to patients (pts) who are not eligible previously for high dose chemotherapy or total body irradiation.We describe infectious morbidity related to this new procedure in our unit in a retrospective study.Results: 45 AHSCT with NMCR were performed in our unit between 1997 to 2001,32 males, 13 females, with a median age of 48 years (range 18-62).Hematologic diagnosis were 8 AL, 12 MM, 2 CML, 5 NHL, 3 MDS, 6 Hodgkin diseases, 3 CLL, 6 solid tumors.Engraftment was observed in all pts with a median of 21 days (range 12119) for PNN >0.5 g/l, and 18 days (range O-201) for platelets >50 g/l.Ten pts received donor lymphocyte infusions (DLI).Nineteen pts (48.7%) presented acute GVHD: 7 without any DLI, 4 before DLI and 8 after DLI (2 grade 1,7 grade 2,4 grade 3 and 2 grade 4).Nineteen pts (42%) presented 39 infections : 1 episode, II = 7; 2 episodes, II = 7; 3 episodes, it = 3; 4 episodes, n= 1; 5 episodes, y1= 1. Twenty two infections (56.5 %) occured in 13 pts during 3 months post transplant : 18 septicemia (12 Gram-negative bacilli, 5 Gram-positive cocci, one yeast), 1 septic chock without documentation, 2 cytomegalovirus (CMV) infections, 1 zoster.Only 4 of these infections occured after engraftment (3 bacterial septicemia and 1 CMV disease).The pt with fungal septicemia died before engraftment.We observed 17 late infections (43.5%) in 11 pts : 3 septicemia, 1 septic chock without documentation, 2 CMV diseases, 6 probable invasive aspergillosis, 1 zoster, 1 Campylobacter colitis, 1 Staphylococcus aureus pneumonia, 1 EBV lymphoma and 1 enterovirus encephalitis.Overall, bacterial infections were observed in 56% of cases, viral in 20% and fungal in 18%.No infection occured in 26 pts (58%).Five pts with hematologic malignancy relapse presented a probable invasive aspergillosis.Twenty eight pts died (62%) 16 in relapse, 9 (32%) with infection : 1 fungal septicemia, 1 viral encephalitis, 1 hepatitis, 6 invasive aspergillosis.Conclusion: Most of infections observed after AHSCT with NMCR were bacterial in our experience.
Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities (2018)

Atropisomeric drug substances are known to have different biological properties. Compounds containing the <i>N</i>-benzoylbenzazepine motif have been shown to exhibit energetically restricted rotation around the Ar(CO)N axis. Herein we report, for the first time, the synthesis, physical characterisation and anti-viral profiles of a series of C-4 and C-5 methylated thieno-benzazepines. NMR analysis reveals that incorporation of a single additional substituent at either of these loci influences the conformational dynamics of the azepine ring system. In the case of the C-5 alkyl analogues, the influence of the new stereocentre is so pronounced that its absolute configuration determines which unique atropisomer is obtained following the generation of the benzazepine nucleus. Screening of the alkylated derivatives for their anti-respiratory syncytial virus (RSV) activity indicates that the desired viral pathogenicity is strongly associated with the conformation adopted by the modified tricyclic scaffolds. This is particularly evident in the case of the C-5 homologues in which one atropisomer was found to be potently active and the other essentially inert. These results provide compelling evidence that we have determined the bioactive conformation shared by RSV inhibitors that employ the thienobenazapine nucleus as their core molecular architecture. Furthermore, the understanding obtained from these studies may make it possible to design improved agents against RSV infection in the future.
Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. (1988)

Highly purified peripheral blood monocytes were cultured in the presence of rIL-4. Major changes in the morphology of the monocytes were observed. After day 5 of culturing the cells acquired a macrophage-like appearance, with increased cell size and extensive processes, suggesting that IL-4 may induce monocyte-macrophage differentiation. This notion is supported by the observed increased expression of MHC class II Ag, which is thought to be associated with monocyte differentiation. Exposure of monocytes to IL-4 resulted in a dose-dependent increase of the expression of MHC class II Ag, which became apparent after only 20 h of incubation. Maximal expression was obtained after incubation for 6 days, and persisted throughout the whole culture period. Similarly, IL-4 increased the expression of R for C3bi and p150.95 Ag, two members of the leukocyte function-associated Ag 1 family, whereas the expression of the third member, leukocyte function-associated Ag 1, remained unchanged during culture. Furthermore, it was shown that IL-4 inhibited the secretion of cytostatic and chemotactic compounds. Supernatants of monocytes cultured with IL-4 were, in contrast to control cultures, much less effective in inhibiting the growth of A375 melanoma cells. In addition, these supernatants failed to direct the migration of freshly isolated monocytes in a chemotaxis assay. Further analysis revealed that these supernatants exhibited reduced IL-1 activity, as measured in a mouse thymocyte proliferation assay, which might explain the low cytostatic and chemotactic activity. Taken together these results show that IL-4 modulates monocyte phenotype and function and may induce monocyte-macrophage differentiation in vitro.
Polymeric Acceptor Semiconductors for Organic Solar Cells (2014)

This chapter contains sections titled: Introduction Basics Principles and Operation for Organic Solar Cells Polymeric Acceptor Semiconductors Conclusions and Perspective
Fig S1 from A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes (2023)

&lt;p&gt;Recycling rounds&lt;/p&gt;
Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging (2019)

Clinical vasodilator stress CMR is associated with patient mortality in a large, diverse population of patients with known or suspected CAD as well as in multiple subpopulations defined by history of CAD and left ventricular ejection fraction. These findings provide a foundational motivation to study the comparative effectiveness of stress CMR against other modalities.
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging (2004)

Neuronal ceroid lipofuscinoses (NCL) comprise the most common group of childhood encephalopathies caused by mutations in eight genetic loci, CLN1-CLN8. Here, we have developed a novel mouse model for the human vLINCL (CLN5) by targeted deletion of exon 3 of the mouse Cln5 gene. The Cln5-/- mice showed loss of vision and accumulation of autofluorescent storage material in the central nervous system (CNS) and peripheral tissues without prominent brain atrophy. The ultrastructure of the storage material accurately replicated the abnormalities in human patients revealing mixture of lamellar profiles including fingerprint profiles as well as curvilinear and rectilinear bodies in electronmicroscopic analysis. Prominent loss of a subset of GABAergic interneurons in several brain areas was seen in the Cln5-/- mice. Transcript profiling of the brains of the Cln5-/- mice revealed altered expression in several genes involved in neurodegeneration, as well as in defense and immune response, typical of age-associated changes in the CNS. Downregulation of structural components of myelin was detected and this agrees well with the hypomyelination seen in the human vLINCL patients. In general, the progressive pathology of the Cln5-/- brain mimics the symptoms of the corresponding neurodegenerative disorder in man. Since the Cln5-/- mice do not exhibit significant brain atrophy, these mice could serve as models for studies on molecular processes associated with advanced aging.
Thermodynamic analysis for the prediction of N composition in coherently grown GaAsN for a multi-junction solar cell (2011)

Thermodynamic analysis was performed to investigate the coherent growth of GaAs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> thin films with low N content. In the present study, a new algorithm of the simulation code was developed to theoretically predict the relationship between solid composition and growth condition. This algorithm is applicable to wider varieties of combinations of gaseous sources than is the traditional algorithm. The system using trimethylgalllium (TMG), AsH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , and NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> was analyzed with the new code, and the results showed that the required input partial pressure ratio of NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> to the group-V element is over 99% for incorporation of a small percent of N into a solid. It is difficult to incorporate N into the solid when the input V/III ratio is low, while in the case of a high input V/III ratio, stable growth with a small percent of N can proceed. In the case of coherently grown GaAs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> , the lattice constraint from the substrate would suppress the incorporation of nitrogen. On the other hand, a higher input Ga partial pressure ratio enhances the stable growth of GaAs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> with a small N content, though this condition tends to easily induce generation of dislocations. Furthermore, a much lower optimum N/As ratio in input gas can be achieved in the system with dimethylhydrazine (DMHy). This result confirms that the difference in gaseous sources has a great effect on N incorporation. When determining well-optimized experimental growth conditions, these influences including crystallinity should all be considered.
Cu−Catalyzed Enantioselective Conjugate Addition of Alkylzincs to Cyclic Nitroalkenes:  Catalytic Asymmetric Synthesis of Cyclic α-Substituted Ketones (2002)

An efficient and highly enantioselective (>/=92% ee) catalytic method for conjugate addition of alkylzinc reagents to cyclic nitroalkenes is reported. Reactions are promoted in the presence of 0.5-5 mol % (CuOTf)2.C6H6 and 1-10 mol % of chiral amino acid-based phosphine ligands at 0 degrees C in toluene. The Cu-catalyzed reactions can be effectively carried out with small-, medium-, and large-ring nitroalkenes. Depending on the reaction conditions used, either the nitro or the corresponding alpha-substituted ketone product can be readily accessed by the present protocol.
Supplementary Materials and Methods from Identification of the <i>IFITM</i> Family as a New Molecular Marker in Human Colorectal Tumors (2023)

Supplementary Materials and Methods from Identification of the &lt;i&gt;IFITM&lt;/i&gt; Family as a New Molecular Marker in Human Colorectal Tumors
Laparoscopic-assisted lumboperitoneal shunt: a simplified technique. (2002)

Laparoscopy-assisted lumboperitoneal shunt offers many advantages over percutaneous ventriculoperitoneal or laparoscopic transabdominal lumboperitoneal shunts. The procedure can be performed in less than 30 minutes by any practicing laparoscopist.
A parallel architecture for serializable production systems (1995)

This dissertation introduces a new parallel architecture for implementing production systems. Key innovations include the elimination of global synchronization before each production firing and the overlapping between the matching and the select-act phases of Production Systems. These innovations are made possible by the use of modern associative memory devices as control supporting structures. Allowing a production to fire before the matching of previous production firings is complete proved to be very efficient. The results produced by the architecture are proven to be correct according to the serializability criterion.
The development of a new benchmark addresses the lack of good benchmarks for the study of novel production system architectures. This benchmark allows for variations in the number of productions, database size, size of local data clusters, and ratio between local and global data.
A study of the production partition problem resulted in four different algorithms. These algorithms take into consideration processor workload balance, production interdependency, replication of data in memory, and reduction of communication traffic. Experimental studies with a comprehensive event driven simulator indicate that the use of dynamic information from previous runs produces more successful algorithms.
A comparative study with a parallel architecture that does global synchronization before every production firing shows that both improvements, namely the elimination of global synchronization and the overlapping between matching, selecting and firing, are very effective in improving the performance of production systems. Further measurements indicate that only a modest amount of associative memory is needed for this architecture and that the use of a bus as an interconnection network does not constitute a bottleneck.
Finally, a multiple functional unit Rete Network is considered within each processor of the architecture. New synchronization problems appear when multiple tokens are concurrently propagated through the Rete Network. Two synchronizing buffers assure correct operation of the architecture. Performance evaluations through system simulation and through analytical modeling indicate that using a modest number of functional units in the Rete Network is cost effective, but the architecture clearly yields diminishing returns when tens of functional units are used.
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors (2012)

The modulation of 11β-HSD1 activity with selective inhibitors has beneficial effects on various metabolic disorders including insulin resistance, dyslipidemia and obesity. Here we report the discovery of a series of novel adamantyl carboxamide and acetamide derivatives as selective inhibitors of human 11β-HSD1 in HEK-293 cells transfected with the HSD11B1 gene. Optimization based on an initially identified 11β-HSD1 inhibitor (3) led to the discovery of potent inhibitors with IC(50) values in the 100 nM range. These compounds are also highly selective 11β-HSD1 inhibitors with no activity against 11β-HSD2 and 17β-HSD1. Compound 15 (IC(50)=114 nM) with weak inhibitory activity against the key human cytochrome P450 enzymes and moderate stability in incubation with human liver microsomes is worthy of further development. Importantly, compound 41 (IC(50)=280 nM) provides a new lead that incorporates an adamantyl group surrogate and should enable further series diversification.
<title>Spectroscopic characterization of upconverting phosphor reporters</title> (1997)

We examined the spectroscopic properties of a novel class of reporters for biomedical diagnostics called upconverting phosphors. These materials exhibit high emission efficiencies, extremely low background levels, no photobleaching, minimal phototoxicity and a variety of emission bands suitable for multi-analyte assays. In addition, they are buffer insensitive and can be excited with inexpensive and compact diode lasers. These properties are very useful for immunoassays, nucleic acid assays, in vivo diagnostics, and other applications. We synthesized submicron monodisperse phosphors and measured the emission spectra, excitation spectra, and power dependencies for a variety of phosphor materials containing different active rare earth ions and host materials. In this paper, we discuss the relation between spectral properties and diagnostic applications.
Broadening Intellectual Diversity in Visualization Research Papers (2019)

Promoting a wider range of contribution types can facilitate healthy growth of the visualization community, while increasing the intellectual diversity of visualization research papers. In this paper, we discuss the importance of contribution types and summarize contribution types that can be meaningful in visualization research. We also propose several concrete next steps we can and should take to ensure a successful launch of the contribution types.