gebhart/patrepeval huggingface dataset:
Analysis of a correlated queue in a communication system (1993)

A family of queues is studied for which the service time B/sub n/ of customer n and the interarrival time I/sub n/ between customers n-1 and n exhibit some sort of proportionality. The focus is on dependencies that arise naturally in the context of communication systems, where the finite speed of the communication links constrains the amount of data that can be received in a given time interval. The simple case of a deterministic proportionality relation between the service time of a customer and its preceding interarrival time is considered. This is extended to allow the addition of an independent, generally distributed overhead to the service time of each customer. Several models that capture the ON-OFF behavior of communication links in packet networks are considered. In all cases, expressions for the delay experienced by a packet in the system are provided. Numerical examples illustrate the impact of dependencies through comparison with less accurate models. The results should be of relevance to environments other than communication as well.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Accelerated Memory Cell Homeostasis during T Cell Depletion and Approaches to Overcome It (2006)

Partial T cell depletion is used in solid organ transplantation as a valuable strategy of peritransplant induction immunosuppression. Using a murine cardiac allograft model, we recently demonstrated that this led to lymphopenia-induced (homeostatic) proliferation among the residual nondepleted lymphocytes. Rather than promoting tolerance, peritransplant T cell-depleting Abs actually resulted in resistance to tolerance induction by costimulatory blockade. In this study we show that memory T cells predominate shortly after subtotal lymphodepletion due to two distinct mechanisms: relative resistance to depletion and enhanced homeostatic proliferation. In contrast, regulatory cells (CD4+ CD25+ Foxp3+) are depleted as efficiently as nonregulatory cells and exhibit reduced homeostatic expansion compared with memory cells. The resistance to tolerance induction seen with subtotal T cell depletion can be overcome in two different ways: first, by the adoptive transfer of additional unprimed regulatory cells at the time of transplant, and second, by the adjunctive use of nondepleting anti-CD4 and anti-CD8 mAbs, which effectively block homeostatic expansion. We conclude that the resistance to tolerance induction seen after subtotal lymphocyte depletion can be attributed to alterations in the balance of naive, memory, and regulatory T cells. These data have clinically relevant implications related to the development of novel strategies to overcome resistance to tolerance.
Technology Implementation for Mental Health End Users: A Model to Guide Digital Transformation for Inpatient Mental Health Professionals (Preprint) (2022)

<sec> <title>UNSTRUCTURED</title> Digital transformation is the adoption of digital technologies by an entity in an effort to increase operational efficiency. In mental health care, digital transformation entails technology implementation to improve the quality of care and mental health outcomes. Most psychiatric hospitals rely heavily on “high-touch” interventions or those that require in-person, face-to-face interaction with the patient. Those that are exploring digital mental health care interventions, particularly for outpatient care, often copiously commit to the “high-tech” model, losing the crucial human element. The process of digital transformation, especially within acute psychiatric treatment settings, is in its infancy. Existing implementation models outline the development of patient-facing treatment interventions within the primary care system; however, to our knowledge, there is no proposed or established model for implementing a new provider-facing ministration tool within an acute inpatient psychiatric setting. Solving the complex challenges within mental health care demands that new mental health technology is developed in concert with a use protocol by and for the inpatient mental health professional (IMHP; the end user), allowing the “high-touch” to inform the “high-tech” and vice versa. Therefore, in this viewpoint article, we propose the Technology Implementation for Mental-Health End-Users framework, which outlines the process for developing a prototype of an IMHP-facing digital intervention tool in parallel with a protocol for the IMHP end user to deliver the intervention. By balancing the design of the digital mental health care intervention tool with IMHP end user resource development, we can significantly improve mental health outcomes and pioneer digital transformation nationwide. </sec>
Targeted approaches to induce immune tolerance for Pompe disease therapy (2016)

Enzyme and gene replacement strategies have developed into viable therapeutic approaches for the treatment of Pompe disease (acid α-glucosidase (GAA) deficiency). Unfortunately, the introduction of GAA and viral vectors encoding the enzyme can lead to detrimental immune responses that attenuate treatment benefits and can impact patient safety. Preclinical and clinical experience in addressing humoral responses toward enzyme and gene therapy for Pompe disease have provided greater understanding of the immunological consequences of the provided therapy. B- and T-cell modulation has been shown to be effective in preventing infusion-associated reactions during enzyme replacement therapy in patients and has shown similar success in the context of gene therapy. Additional techniques to induce humoral tolerance for Pompe disease have been the targeted expression or delivery of GAA to discrete cell types or tissues such as the gut-associated lymphoid tissues, red blood cells, hematopoietic stem cells, and the liver. Research into overcoming preexisting immunity through immunomodulation and gene transfer are becoming increasingly important to achieve long-term efficacy. This review highlights the advances in therapies as well as the improved understanding of the molecular mechanisms involved in the humoral immune response with emphasis on methods employed to overcome responses associated with enzyme and gene therapies for Pompe disease.
3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting (2017)

1. Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:793-800.
Novel thermally enhanced power package (2010)

Heat generated in microelectronic devices as a result of dissipated power is a major issue in power electronics applications resulting in elevated application PC board temperatures. In order to minimize the down ward heat transfer to the application board an efficient method enabling the upward flow of heat from the silicon die to the top of the microelectronic package and subsequently transferred to the environment via forced convection needs to be employed. The problem is that most of the current packaging technologies have a very poor junction-to-top thermal resistance so it is very difficult to have a substantial portion of the heat flowing to the top of the device. In this paper we present a novel power package design that enables heat conduction to the top surface of the microelectronic package through the use of a high thermal conductivity path which reduces by more than a factor of ten the junction-to-top thermal resistance compared to standard solutions. The thermal resistance junction-to-top is found to be as low as 1 C/W, which is comparable with thermal resistance junction to board. This allows for a significant portion of the dissipated energy in the die to be conducted to the topside of the package where natural or forced convection can transfer the heat to the air. We discuss the design, manufacturability, performance and reliability of the package as well as thermal measurements which demonstrates the ability of the package to dissipate the heat. We also compare this solution with existing solution sin the marketplace.
Sub-&#x03BC;W standby power, &#x003C;18 &#x03BC;W/DMIPS@25MHz MCU with embedded atom-switch programmable logic and ROM (2015)

A non-volatile programmable logic (NPL) with atom switch significantly accelerates performance of micro-controller unit. A low-power 32bit-CPU using a 65 nm-node Silicon-on-Thin-Box (SOTB) CMOS performs 1.95 DMIPS/MHz and 33 μW/MHz on 25 MHz and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</inf> =0.4V. When a software process in the CPU is offloaded to NPL, the 9 times faster processing speed and 3 times higher energy efficiency are realized. A reverse body-bias on SOTB CMOS and a power-off of NPL block suppress a standby power down to 0.7 μW.
Discrimination of Single Mutations in Cancer-Related Gene Fragments with a Surface Acoustic Wave Sensor (2006)

Here, we report on using a surface acoustic wave sensor for the highly sensitive and accurate detection of individual point mutations in cancer-related gene DNA fragments from single injections. Our sensor measures both the mass and viscosity signals and, thus, allows discriminating between mass effects resulting from hybridization of short DNA strands and viscosity effects due to increasing amounts of DNA deposited on the sensor. Single nucleotide exchanges or deletions are distinguished reliably and with exceeding simplicity from the wild-type sequences, on the basis of differences in their dissociation or association rates starting at low nanomolar concentrations. Mutant oligonucleotides were identified immediately from viewing the recorded signal and without further processing of the data. Multiple repeated binding cycles were possible over days without affecting sensitivity. To achieve signal amplification, our new bioassay can also apply multiple hybridization steps based on sandwich hybridizations. Kinetic evaluations gave insight into the physicochemical properties of the fragments used that explain the differences in their binding processes.
Discrete Double‐to‐Quadruple Aromatic Stacks: Stepwise Integration of Face‐to‐Face Geometries in Cocrystals Based on Indolocarbazole (2013)

One, two, three, four: An indolocarbazole organizes double, triple, and quadruple stacks of aromatic molecules within multicomponent solids. The aromatic units are sequentially integrated into discrete assemblies and undergo [2+2] photodimerization. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<title>Loading mechanism of DVD-RAM drive</title> (1998)

We have developed a loading mechanism of DVD-RAM drive for DVD-RAM, PD, DVD-ROM, and CDs. To load both a cartridge and a bare disc, a pair of disc holding members is equipped in a cartridge holder. The front half of the cartridge holder is drawn out of the drive, and a cartridge or a disc is inserted from the front, and so the drive can be used in both horizontal and vertical setup directions. The drive mechanism height is minimized to 31.6 mm by pulling the cartridge holder into the drive after opening the cartridge shutter. It provides enough space for the electric circuit board below the mechanism in the height of 41.3 mm of the half height drive. When a disc is inserted, the cartridge holder is pulled into the drive without pushing the cartridge holder using sensors in the cartridge holder.
Photocycloaddition of Alkenes (Dienes) to Dienes ([4þ 2]/[4þ 4]) (2004)

Among the earliest photochemical reactions was photodimerization of anthracene 1 to give dimer 2 (Sch. 1), reported by Fritzsche in 1867 [1-3]. While not technically a reaction of 1,3-dienes, it was the first [4þ4] cycloaddition reaction, and predates the first [2þ2] photocycloaddition by a decade [3]. More than fifty years would pass before investigations of 1,3diene photochemistry would be undertaken, and cycloaddition reactions were not reported until the early 1960s. The initial investigations, mercurysensitized reactions of dienes, reported fragmentations [4]. Seminal investigations by Srinivasan at the University of Rochester in 1960 [5] and they by Hammond at the California Institute of Technology [6] led to the first examples of photo-[2þ2], [4þ2] and [4þ4] cycloadditions by 1,3-dienes. Continuing studies of diene photochemistry have refined our understandings of the interrelated aspects of the chemistry that include conformation, exiplex and intermediate lifetimes. Several reviews have concentrated on 1,3-diene photochemistry [7-9].
Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis (1987)

A five-year prospective study of cutaneous leishmaniasis in an endemic area of Brazil revealed an annual incidence of disease of 8.1 per 1000 inhabitants and a prevalence of 14.9%. The disease fluctuated as a series of mini-epidemics. Most disease occurred in individuals who were 10-30 years of age. Mucosal disease occurred in 2.7% of patients with primary lesions and occurred a median of six years after this lesion. Disease was more common in males, in those with either large or multiple antecedent skin lesions, and in those with incomplete antimony therapy for the primary lesions. An ELISA was positive in 85% of those tested during the first two years after the primary lesion and remained positive for five to 40 years in 27% of patients. Skin testing was positive in 96% of patients with recent lesions and remained positive in 70% of patients. All patients with mucosal disease had positive serological and skin tests.
The Tomato Cf-9 Disease Resistance Gene Functions in Tobacco and Potato to Confer Responsiveness to the Fungal Avirulence Gene Product Avr9 (1998)

The Cf-9 gene encodes an extracytoplasmic leucine-rich repeat protein that confers resistance in tomato to races of the fungus Cladosporium fulvum that express the corresponding avirulence gene Avr 9. We investigated whether the genomic Cf-9 gene functions in potato and tobacco. Transgenic tobacco and potato plants carrying Cf-9 exhibit a rapid hypersensitive cell death response (HR) to Avr 9 peptide injection. Cf 9 tobacco plants were reciprocally crossed to Avr 9-producing tobacco. A developmentally regulated seedling lethal phenotype occurred in F1 progeny when Cf9 was used as the male parent and Avr 9 as the female parent. However, when Cf9 was inherited in the maternal tissue and a heterozygous Avr 9 plant was used as the pollen donor, a much earlier reaction was caused, leading to no germination of any F1 seed. Detailed analysis of the Avr 9-induced responses in Cf 9 tobacco leaves revealed that (1) most mesophyll cells died within 3 hr (compared with 12 to 16 hr in tomato); (2) the macroscopic HR was visible at an Avr 9 titer five times lower than that which caused visible symptoms in tomato; (3) the HR invariably extended into noninjected panels of the tobacco leaf; (4) no HR occurred in leaves of young tobacco plants; (5) in older plants, the HR was dramatically enhanced by sequential Avr 9 challenges; and (6) coexpression of a salicylate hydroxylase transgene (nahG) from Pseudomonas putida reduced the severity of the macroscopic leaf HR and also restored germination to Cf 9 x 35S:Avr 9 F1 seedlings. Simultaneous introduction of Cf-9 homologs (Hcr 9-9 genes A and B or D) along with the native Cf-9 gene did not alter the responses that were specifically induced by Avr 9. Various ways to use the Cf-9-Avr 9 gene combination to engineer broad-spectrum disease resistance in several solanaceous species are discussed.
Current Concepts Review (2007)

Awareness of the medial patellofemoral ligament has increased markedly over the past decade. Previously, this structure, which was delineated in anatomical studies, had been little recognized and underestimated with regard to its importance in stabilizing the patella. The goal of this review of the medial patellofemoral ligament is to develop a current understanding of how this ligament functions in patellofemoral stability and to review the current treatment options for medial patellofemoral ligament disruption.
MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I (1996)

1. A 31-amino-acid peptide from the venom of the snail-hunting species Conus marmoreus, microO-conotoxin MrVIA, inhibits mammalian voltage-gated sodium channels through a novel mechanism distinct from saxitoxin, tetrodotoxin, or mu-conotoxin. 2. MicroO-Conotoxin MrVIA blocks rat brain type II sodium channels expressed in Xenopus oocytes (IC50 approximately 200 nM, Hill coefficient approximately 1.6 +/- 0.2, mean +/- SE). Channel activation/inactivation kinetics and current-voltage relationships were unperturbed. 3. MicroO-Conotoxin MrVIA does not cause phasic or use-dependent inhibition of sodium currents measured in Xenopus oocytes expressing rat brain type II sodium channels, but shifts the steady-state availability of these sodium channels to more hyperpolarized potentials. 4. MicroO-Conotoxin MrVIA inhibited rapidly inactivating sodium channel conductance in rat hippocampal cells in culture. The inhibition was rapidly reversible. 5. MicroO-Conotoxin MrVIA does not displace specific [3H]saxitoxin binding to either rat brain or Electrophorus electric organ sites, indicating inhibitory effects mediated through a binding site distinct from site I.
An in vitro chemosensitivity test for solid human tumors using collagen gel droplet embedded cultures (1997)

In vitro chemosensitivity testing using a collagen gel droplet embedded culture drug sensitivity test (CD-DST), was conducted with several types of solid cancer. The overall evaluable rate was 80% (443/554), including 76% for lung (n=243), 78% for breast (n=110), 87% for gastric (n=62), 83% for colorectal (n=107) cancers and 88% for 32 metastatic brain tumors. The in vitro sensitivity of breast, gastric and colorectal cancers to mitomycin C (MMC), cisplatin (CDDP), 5-fluorouracil (5-FU) and doxorubicin (DXR) was similar to the efficacy rates reported for each drug. This was also observed with lung cancer, the sensitivity of which to MMC, CDDP, vindesine (VDS) and etoposide (VP-16) was similar to the clinical efficacy. The clinical response to chemotherapy was compared with the results of in vitro chemosensitivity testing in Il patients: the clinical correlation was 91%, with a 80% true positive and 100% true negative rate. These results suggest that the CD-DST may be clinically useful by allowing the prediction of clinical response in various solid cancers.
ROUTINE ICU MONITORING FAILS TO DETECT POSTOPERATIVE MYOCARDIAL ISCHEMIA (1998)

Society of Critical Care Medicine; 27th Educational and Scientific Symposium; San Antonio, Texas, USA; February 4-8, 1998: Poster Hall: Thursday, February 5, 1998 5: 45-7: 15 pm; Friday, February 6, 1998 11: 40 am-1: 00 pm; Saturday, February 7, 1998 11: 40 am-1: 00 pm: Poster Presentations: Computers/Technology
Effect of codoping on scintillation and optical properties of a Ce-doped Gd3Ga3Al2O12scintillator (2013)

Single crystals of Gd3Ga3Al2O12 : Ce with different codopants were successfully grown using the Czochralski technique. Optical and scintillation properties of these codoped crystals were studied in detail including absorption, photoluminescence excitation and emission, decay time and thermoluminescence. This study revealed that while boron codoping improves the scintillation light output and energy resolution and decreases self-absorption in these crystals, calcium codoping affects their properties in the opposite manner. In addition to antisite defects, the effect of room temperature trap centres on the sensitivity of these crystals to light exposure is also reported for the first time. Light sensitivity was also found to be affected with the incorporation of codopants in the lattice. The effect of annealing in oxidizing and reducing atmospheres on the scintillation and optical properties of differently codoped crystals was also investigated in detail in order to better understand the defect structure of these crystals. All these measurements together are used to explain the effect of codoping on the crystal field and defect structure of these crystals.
Operational readiness review plan for the radioisotope thermoelectric generator materials production tasks (1990)

In October 1989, a US shuttle lifted off from Cape Kennedy carrying the spacecraft Galileo on its mission to Jupiter. In November 1990, a second spacecraft, Ulysses, will be launched from Cape Kennedy with a mission to study the polar regions of the sun. The prime source of power for both spacecraft is a series of radioisotope thermoelectric generators (RTGs), which use plutonium oxide (plutonia) as a heat source. Several of the key components in this power system are required to ensure the safety of both the public and the environment and were manufactured at Oak Ridge National Laboratory (ORNL) in the 1980 to 1983 period. For these two missions, Martin Marietta Energy Systems, Inc. (Energy Systems), will provide an iridium-alloy component used to contain the plutonia heat source and a carbon-composite material that serves as a thermal insulator. ORNL alone will continue to fabricate the carbon-composite material. Because of the importance to DOE that Energy Systems deliver these high-quality components on time, performance of an Operational Readiness Review (ORR) of these manufacturing activities is necessary. Energy Systems Policy GP-24 entitled Operational Readiness Process'' describes the formal and comprehensive process by which appropriate Energy Systems activities are to be reviewed to ensure their readiness. This Energy System policy is aimed at reducing the risks associated with mission success and requires a management-approved readiness plan'' to be issued. This document is the readiness plan for the RTG materials production tasks. 6 refs., 11 figs., 1 tab.
Nanoscale heat transport probed with soft-x-rays (2008)

We characterize heat transport in nanostructures, using coherent soft-X-rays to probe thermal surface deformation. By varying the substrate temperature, we observe the transition from diffusive to quasi-ballistic heat transport regimes.
FFitts law (2013)

Fitts' law has proven to be a strong predictor of pointing performance under a wide range of conditions. However, it has been insufficient in modeling small-target acquisition with finger-touch based input on screens. We propose a dual-distribution hypothesis to interpret the distribution of the endpoints in finger touch input. We hypothesize the movement endpoint distribution as a sum of two independent normal distributions. One distribution reflects the relative precision governed by the speed-accuracy tradeoff rule in the human motor system, and the other captures the absolute precision of finger touch independent of the speed-accuracy tradeoff effect. Based on this hypothesis, we derived the FFitts model - an expansion of Fitts' law for finger touch input. We present three experiments in 1D target acquisition, 2D target acquisition and touchscreen keyboard typing tasks respectively. The results showed that FFitts law is more accurate than Fitts' law in modeling finger input on touchscreens. At 0.91 or a greater R2 value, FFitts' index of difficulty is able to account for significantly more variance than conventional Fitts' index of difficulty based on either a nominal target width or an effective target width in all the three experiments.