gebhart/patrepeval huggingface dataset:
Low-Loss Characteristics of a Multimode Polymer Optical Waveguide at 1.3 um Wavelength on an Electrical Hybrid LSI Package Substrate (2016)

We propose an optical and electrical hybrid LSI package with high bandwidth of 2.4 Tb/s and parallel multi-mode optical links at 1.3 µm using a polymer optical waveguide and our original optical I/O module. We report a silicate based organic-inorganic hybrid polymer optical circuit fabrication including waveguide, mirror and connector on electrical LSI package substrate. We also present about the propagation loss, bending loss and coupling loss at 1.3 µm using a MMF and a Si photonics transmitter. The propagation loss of the multimode polymer waveguide is 0.3 dB/cm at 1.3 µm. The minimum bending radian and value generated additional loss is 5 mm and 0.2 dB, respectively. The coupling loss of butt-coupling and mirror coupling from the polymer optical waveguide to the MMF is 0.4 dB and 1.2 dB, respectively. In addition, we measure the optical characteristics of LSI package substrate using our Si photonics transmitter integrated with vertical polymer waveguide.
Inline Millimeter Wave Radar Phase Measurements utilizing High Order Waveguide Modes (2019)

In this paper, we present a new concept for extremely sensitive frequency modulated continuous wave radar measurements within waveguides. Basis for this concept is the millimeter wave radar’s outstandingly broad bandwidth that ensures precise detection of targets and its particularly sensitive phase. Moreover, the conversion of the fundamental TE 11 to the higher TE 01 mode with a broadband mode converter allows for advanced inline measurement setups. Therefore, simulations concerning the mode behavior are discussed and measurements that confirm the presented theory are demonstrated.
Probe‐based fluorescence dosimetry of an antibody‐dye conjugate to identify head and neck cancer as a first step to fluorescence‐guided tissue preselection for pathological assessment (2019)

Fluorescence-guided tissue preselection using a fluorescence dosimeter could have substantial impact on tissue sampling for frozen section analysis and potentially reduce sampling errors.
Exciton annihilation and dephasing dynamics in semiconducting single-walled carbon nanotubes (2010)

Semiconducting single-walled carbon nanotubes (SWNTs) are one of the most intriguing nanomaterials due to their large aspect ratios, size tunable properties, and dominant many body interactions. While the dynamics of exciton population relaxation have been well characterized, optical dephasing processes have only been examined indirectly through steady-state measurements such as single-molecule spectroscopy that can yield highly variable estimates of the homogeneous linewidth. To bring clarity to these conflicting estimates, a time-domain measurement of exciton dephasing at an ensemble level is necessary. Using two-pulse photon echo (2PE) spectroscopy, comparatively long dephasing times approaching 200 fs are extracted for the (6,5) tube species at room temperature. In this contribution, we extend our previous study of 2PE and pump-probe spectroscopy to low temperatures to investigate inelastic exciton-exciton scattering. In contrast to the population kinetics observed upon excitation of the second transition-allowed excitonic state (<i>E</i><sub>22</sub>), our one-color pump-probe data instead shows faster relaxation upon cooling to 60 K when the lowest transition-allowed state (<i>E</i><sub>11</sub>) is directly excited for the (6,5) tube species. Analysis of the kinetics obtained suggests that the observed acceleration of kinetic decay at low temperature originates from an increasing rate of exciton-exciton annihilation. In order to directly probe exciton-exciton scattering processes, femtosecond 2PE signal is measured as a function of excitation fluence and temperature. Consistent with the observed enhancement of exciton-exciton scattering and annihilation at low temperatures, the dephasing rates show a correlated trend with the temperature dependence of the population lifetimes extracted from one-color pump-probe measurements.
Secretoglobin expression in ovarian carcinoma: lipophilin B gene upregulation as an independent marker of better prognosis (2013)

The present study represents the first quantitative evaluation of secretoglobin gene expression in normal and neoplastic ovarian tissues. Our results demonstrate lipophilin B gene and protein upregulation in ovarian carcinoma compared to normal ovary. Moreover, lipophilin B gene overexpression correlates with a less aggressive tumor phenotype and represents a novel ovarian carcinoma prognostic factor.
Mitigating coherent leakage of superconducting qubits in a large-scale quantum socket (2017)

A practical quantum computer requires quantum bit (qubit) operations with low error rates in extensible architectures. We study a packaging method that makes it possible to address hundreds of superconducting qubits by means of three-dimensional wires: The large-scale quantum socket. A qubit chip is housed in a superconducting box, where both box and chip dimensions lead to unwanted modes that can interfere with qubit operations. We theoretically analyze these interference effects in the context of qubit coherent leakage. We propose two methods to mitigate the resulting errors by detuning the resonance frequency of the modes from the qubit frequency. We perform detailed electromagnetic field simulations indicating that the resonance frequency of the modes increases with the number of installed three-dimensional wires and can be engineered to be significantly higher than the highest qubit frequency. Finally, we show preliminary experimental results towards the implementation of a large-scale quantum socket.
Formal models, usability and related work in IR (editorial for special edition) (2000)

The Glasgow IR group has carried out both theoretical and empirical work, aimed at giving end users efficient and effective access to large collections of multimedia data.
Evaluating the Catalytic Efficiency of the Human Membrane-type 1 Matrix Metalloproteinase (MMP-14) Using AuNP–Peptide Conjugates (2023)

Interactions of plasmonic nanocolloids such as gold nanoparticles and nanorods with proximal dye emitters result in efficient quenching of the dye photoluminescence (PL). This has become a popular strategy for developing analytical biosensors relying on this quenching process for signal transduction. Here, we report on the use of stable PEGylated gold nanoparticles, covalently coupled to dye-labeled peptides, as sensitive optically addressable sensors for determining the catalytic efficiency of the human matrix metalloproteinase-14 (MMP-14), a cancer biomarker. We exploit real-time dye PL recovery triggered by MMP-14 hydrolysis of the AuNP-peptide-dye to extract quantitative analysis of the proteolysis kinetics. Sub-nanomolar limit of detections for MMP-14 has been achieved using our hybrid bioconjugates. In addition, we have used theoretical considerations within a diffusion-collision framework to derive enzyme substrate hydrolysis and inhibition kinetics equations, which allowed us to describe the complexity and irregularity of enzymatic proteolysis of nanosurface-immobilized peptide substrates. Our findings offer a great strategy for the development of highly sensitive and stable biosensors for cancer detection and imaging.
Polarisation-independent tunable bandpass filter utilising symmetric branch beam splitters (2004)

A two-port polarisation-independent electro-optically tunable bandpass filter in Ti:LiNbO3 in the 1535 nm wavelength regime using strain-induced polarisation conversion with a tuning rate of 0.082 nm/V and a tuning range of 13 nm is reported.
Actinobaculum massiliense Proteome Profiled in Polymicrobial Urethral Catheter Biofilms (2018)

<i>Actinobaculum massiliense</i>, a Gram-positive anaerobic coccoid rod colonizing the human urinary tract, belongs to the taxonomic class of Actinobacteria. We identified <i>A. massiliense</i> as a cohabitant of urethral catheter biofilms (CB). The CBs also harbored more common uropathogens, such as <i>Proteus mirabilis</i> and <i>Aerococcus urinae</i>, supporting the notion that <i>A. massiliense</i> is adapted to a life style in polymicrobial biofilms. We isolated a clinical strain from a blood agar colony and used 16S rRNA gene sequencing and shotgun proteomics to confirm its identity as <i>A. massiliense</i>. We characterized this species by quantitatively comparing the bacterial proteome derived from in vitro growth with that of four clinical samples. The functional relevance of proteins with emphasis on nutrient import and the response to hostile host conditions, showing evidence of neutrophil infiltration, was analyzed. Two putative subtilisin-like proteases and a heme/oligopeptide transporter were abundant in vivo and are likely important for survival and fitness in the biofilm. Proteins facilitating uptake of xylose/glucuronate and oligopeptides, also highly expressed in vivo, may feed metabolites into mixed acid fermentation and peptidolysis pathways, respectively, to generate energy. A polyketide synthase predicted to generate a secondary metabolite that interacts with either the human host or co-colonizing microbes was also identified. The product of the PKS enzyme may contribute to <i>A. massiliense</i> fitness and persistence in the CBs.
Achieving Hidradenitis Suppurativa Response Score is Associated with Significant Improvement in Clinical and Patient-reported Outcomes: Post Hoc Analysis of Pooled Data From PIONEER I and II (2018)

Hidradenitis Suppurativa Clinical Response (HiSCR), is a validated tool that has been used to assess the efficacy of adalimumab among patients with hidradenitis suppurativa. We evaluated the clinical meaning of HiSCR by relating it to patient-reported outcomes to give further context to its achievement in a post hoc analysis of integrated data from two phase 3 clinical trials (PIONEER I and II). Pooling placebo and active treatment arms, 39% of patients (245/629) achieved HiSCR at week 12. Irrespective of treatment, significantly (p <0.05) more HiSCR responders than non-responders experienced clinically meaningful improvement in Dermatology Life Quality Index (60.5% vs 30.4%), Pain Numeric Rating Scale (46.9% vs 19.9%), hidradenitis suppurativa quality of life (49.4% vs 26.9%), work-related performance (52.6% vs 37.7%), and non-work-related performance (59.5% vs 33.3%). Clinically meaningful outcomes in hidradenitis suppurativa are more likely to be attained in patients achieving HiSCR level improvement.
Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells (2010)

Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-carcinoembryonic antigen (CEA) half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding nontargeted nanoparticles.
Solid solution for catalytic ammonia synthesis from nitrogen and hydrogen gases at 50 °C (2020)

The lack of efficient catalysts for ammonia synthesis from N<sub>2</sub> and H<sub>2</sub> gases at the lower temperature of ca. 50 °C has been a problem not only for the Haber-Bosch process, but also for ammonia production toward zero CO<sub>2</sub> emissions. Here, we report a new approach for low temperature ammonia synthesis that uses a stable electron-donating heterogeneous catalyst, cubic CaFH, a solid solution of CaF<sub>2</sub> and CaH<sub>2</sub> formed at low temperatures. The catalyst produced ammonia from N<sub>2</sub> and H<sub>2</sub> gases at 50 °C with an extremely small activation energy of 20 kJ mol<sup>-1</sup>, which is less than half that for conventional catalysts reported. The catalytic performance can be attributed to the weak ionic bonds between Ca<sup>2+</sup> and H<sup>-</sup> ions in the solid solution and the facile release of hydrogen atoms from H<sup>-</sup> sites.
A Low-Power Single-Clock-Driven Scan Driver Using Depletion-Mode a-IGZO TFTs (2012)

A new low-power scan driver using amorphous In-Ga-Zn-O (a-IGZO) thin-film transistor (TFT) is proposed. The proposed scan driver employs only one-clock signal and connects power supply voltage to the drain node of pull-up TFTs in the output stage to reduce the power consumption. The measured power consumption of the proposed scan driver of ten stages is 265 μW at an output voltage of 20 V and a clock frequency of 46.1 kHz, which is the driving condition of the extended graphics array (1024 × 768) panel. The power consumption is less than 11.9% of the previously reported results.
Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry (2019)

ClinicalTrials.gov (NCT01915511).
Two-Dimensional Micropatterns via Crystal Growth of Na2CO3 for Fabrication of Transparent Electrodes (2013)

The simple and versatile method to generate two-dimensional micropatterns by controlling precisely crystallization of sodium carbonate (Na2CO3) was investigated. Dense clusters of dendrites of salt crystals were homogeneously formed in a large area with an aqueous solution of Na2CO3 during evaporation of water. The dimensions and morphologies of dendritic salt crystals were tuned by changing the growth conditions such as salt concentration, relative humidity, and temperature. Then, 2D micropatterns of salt crystals were directly used as a mask for the deposition of a silver (Ag) layer to fabricate transparent electrodes. After salt crystals were completely dissolved in water, the network of an electrically conductive Ag layer, whose patterns were reversely produced from salt crystals, was generated on glass substrates. In addition, salt crystals were used as a master to prepare a replica mold of poly(dimethylsiloxane) (PDMS) for utilizing the imprinting technique. By imprinting a flexible PDMS mold with Ag inks, Ag micropatterns that were perfectly identical to dendrites of salt crystals were transferred to the other substrate.
Ultrasonic Surface Acoustic Wave platform for targeted pulmonary delivery of nano drug vehicles (2019)

This work shows a new method that employs surface acoustic waves (SAW) to form liposomes and simultaneously create a narrow distribution of inhalable aerosols that falls within the ideal respirable range size. The main advantage of using SAW is that, in one step, we can control the aerosols droplet size distribution and simultaneously create drug carriers of biological and active compounds, which are often degraded in alternative nebulisation methods. To corroborate the effectiveness of the proposed SAW nebulisation platform, nucleic acids were nebulised and deliver to lung cancer cells.
Supplemental data Figure 2 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70 (2023)

Supplemental data Figure 2 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Liquid‐Phase Metal Inclusions for a Conductive Polymer Composite (2015)

A highly stretchable and conductive poly(dimethylsiloxane)–galinstan composite that exhibits unique electro­mechanical coupling is developed. Compression irreversibly induces conductivity in the virgin material, and allows for the ability to draw circuits into the composite via selectively applying force. Tensile loading causes an apparent increase in volumetric conductivity, resulting in only modest resistance change when the material is under strains as high as 100%.
Performance Limits of Solutions to Network Utility Maximization Problems (2017)

We study performance limits of solutions to utility maximization problems (e.g., max-min problems) in wireless networks as a function of the power budget $\bar{p}$ available to transmitters. Special focus is devoted to the utility and the transmit energy efficiency (i.e., utility over transmit power) of the solution. Briefly, we show tight bounds for the general class of network utility optimization problems that can be solved by computing conditional eigenvalues of standard interference mappings. The proposed bounds, which are based on the concept of asymptotic functions, are simple to compute, provide us with good estimates of the performance of networks for any value of $\bar{p}$ in many real-world applications, and enable us to determine points in which networks move from a noise limited regime to an interference limited regime. Furthermore, they also show that the utility and the transmit energy efficiency scales as $Θ(1)$ and $Θ(1/\bar{p})$, respectively, as $\bar{p}\to\infty$.
Food Protective Property of New Liquid Food Container PID (Pouch in Dispenser) for Microbes (2011)

We examined the content protection characteristics of the PID (Pouch in Dispenser) when it was used in the usual manner and when it was polluted artificially. When the PID was used in the usual manner, the nozzle was opened, and experiments were carried out with and without air-blowing. The invasion of bacteria into the PID was not detected. Also, no bacteria were detected in the material poured from the nozzle of the PID. When 3 strains of bacteria suspensions were intentionally smeared on the nozzle of the PID, invasion of bacteria was observed. When the PID was wiped with a dirty cloth, no invasion of bacteria into the PID was detected. It may be necessary to label the PID with the instruction that the nozzle should not be touched. The effected of changes in the water activity and pH, and the preservatives used, may also need to be considered, depending on the contents in the PID.
A multiscale stochastic modeling approach to the monitoring of mechanical systems (2002)

Presents results on using a statistical model motivated by the wavelet transform to represent non-stationary signals typically encountered in machinery monitoring applications. The authors propose the use of a frame-based system in which the data in each frame is modeled as a multiscale stochastic process. The parameters of a multiscale model are used as features for each frame, where each frame of features is modeled as a sample of a multivariate, multimodal distribution. Classification of machine states based on monitoring signals is performed by comparing likelihood scores for each machine state. The authors present an example of applying the system to data consisting of a superposition of damped sinusoids, as a way of illustrating system performance for the case of transient monitoring signals. They compare their system to one which is trained using a DFT-based (non-time-frequency-based) representation (in particular, LPC coefficients) and show that their system exhibits both superior performance as well as greater robustness to noise in the signals. They also compare results using multiscale parameters versus LPC coefficients for the case of synthesized autoregressive signals and for the case of actual, measured signals from a weld depth monitoring system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A source-line programming scheme for low-voltage operation NAND flash memories (2000)

To realize a low-voltage operation NAND flash memory, a new source-line programming scheme has been proposed. This architecture drastically reduces the program disturbance without circuit area, manufacturing cost, program speed, or power consumption overhead. In order to improve the program disturbance characteristics, a high program inhibit voltage is applied to the channel from the source line, as opposed to from the bit line of the conventional scheme. The bit-line swing is decreased to 0.5 V to achieve a lower power consumption. Although the conventional NAND flash memory cannot operate below 2.0 V due to the program disturbance issue, the proposed NAND flash memory shows excellent program disturbance characteristics irrespective of the supply voltage. A very fast programming of 192 /spl mu/s/page and a very low power operation of 22 mW at 1.4 V can be realized in the proposed scheme.
Practical quantitative scanning microwave impedance microscopy of semiconductor devices (2017)

Scanning microwave impedance microscopy (sMIM) is an emerging electrical mode for scanning probe microscopy (SPM). We apply the technique to the profiling of dopants in semiconductor samples with sub-micron spatial resolution. This work demonstrates the practical application of sMIM for quantitative measurement of the dopant concentration profile in production semiconductor devices. A planar dopant calibration sample is used to calibrate the sMIM prior to performing the measurements on an “unknown” production device. We utilize nanoscale C-V curves to establish a calibration curve for both n- and p-type carriers in a single reference and apply the calibration curve to an “unknown” device presenting the measurements in units of doping concentration.
Real-Time Priority-Based Cooperative Highway Merging for Heterogeneous Autonomous Traffic (2021)

Highway on-ramp merge junctions remain a major bottleneck in transportation networks. However, with the introduction of Connected Autonomous Vehicles (CAVs) with advanced sensing and communication capabilities modern algorithms can capitalize on the cooperation between vehicles. This paper enhances highway merging efficiency by optimally coordinating CAVs in order to maximize the flow of vehicles while satisfying all safety constraints. Focus is also placed on the effect of varying priorities of different vehicle classes in selecting the best merging sequence. Our algorithm is capable of real time operation through parallel computation, optimized merge sequence generation and management of the diverse needs of heterogeneous (multi-class) traffic. Results are verified through a realistic traffic simulation software.