gebhart/patrepeval huggingface dataset:
Cytotoxic Activity of Rearranged Drimane Meroterpenoids against Colon Cancer Cells via Down-Regulation of β-Catenin Expression (2015)

[Image: see text] Colorectal cancer has emerged as a major cause of death in Western countries. Down-regulation of β-catenin expression has been considered a promising approach for cytotoxic drug formulation. Eight 4,9-friedodrimane-type sesquiterpenoids (1–8) were acquired using the oxidative potential of Verongula rigida on bioactive metabolites from two Smenospongia sponges. Compounds 3 and 4 contain a 2,2-dimethylbenzo[d]oxazol-6(2H)-one moiety as their substituted heterocyclic residues, which is unprecedented in such types of meroterpenoids. Gauge-invariant atomic orbital NMR chemical shift calculations were employed to investigate stereochemical details with support of the application of advanced statistics such as CP3 and DP4. Compounds 2 and 8 and the mixture of 3 and 4 suppressed β-catenin response transcription (CRT) via degrading β-catenin and exhibited cytotoxic activity on colon cancer cells, implying that their anti-CRT potential is, at least in part, one of their underlying antineoplastic mechanisms.
Quick matting: A matting method based on pixel spread and propagation (2010)

The problem of matting is always solved by finding the alpha value for each pixel in the image. Many recent methods combine color sampling and affinity definition in different steps, leading to large computational cost. In the proposed method, when the alpha value of a pixel P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> is calculated, the pixel is regarded as a foreground pixel to help calculate its adjacent pixels' alpha values, resulted in a faster solution. This spreading way of traversal also ensures local continuity of foreground object and improves the visual result. Experiments show our Quick Matting can achieve comparable alpha mattes as Robust Matting, while the speed is enhanced by about 25 times.
Synthesis of 7-Substituted Saccharins and 8-Substituted Oxicams, and a Novel Saccharin to Oxicam Transformation (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of 7-Substituted Saccharins and 8-Substituted Oxicams, and a Novel Saccharin to Oxicam TransformationJohn R. Proudfoot, Usha R. Patel, and Alexey B. DyatkinView Author Information Boehringer Ingelheim Pharmaceuticals Inc., Research and Development, 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877 Cite this: J. Org. Chem. 1997, 62, 6, 1851–1853Publication Date (Web):March 21, 1997Publication History Received17 October 1996Published online21 March 1997Published inissue 1 March 1997https://pubs.acs.org/doi/10.1021/jo961955whttps://doi.org/10.1021/jo961955wbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views592Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cyclization,Halogenation,Heck reaction,Materials,Reaction products Get e-Alerts
Experimental investigation of the effectiveness of Coanda reaction surface geometries for Super-Critical Circulation-Control (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-1993.vid The maximum effectiveness of fluidic Super Critical Circulation Control (SCCC) actuators is limited by separation of the actuating jet at high pressure ratios. An important design goal for SCCC is to maximize actuator effectiveness relative to geometric implementation cost, for which trailing edge radius can be taken as a proxy. For experimental work, actuator effectiveness can be meaningfully assessed under quiescent conditions when the jet total pressure is significantly higher than the intended operational freestream total pressure. A jet with a nozzle pressure ratio of up to 15 was issued from a convergent-only rectangular nozzle with an aspect ratio of 22.5 between two walls to produce a two-dimensional flow into quiescent air. Circular and elliptical reaction surface geometries were tested, with ratios of the nozzle height h to the radius or semi-minor axis of the geometries respectively of 0.025, 0.05, or 0.1, and ellipse eccentricity 1.5 or 2. Geometries were offset to create a base step of height h_s between the nozzle lip and the surface of h_s/h = 0 to 2. Schlieren photography and analysis of static pressures measured on the reaction surfaces was used to investigate the effectiveness of the different geometries with different base step heights. For circular geometries, detachment nozzle pressure ratio agrees with the literature. A scaling of elliptic geometries based on the semi-major axis was shown to provide a collapse onto the commonly used h/R scaling for circular geometries. Jet separation location generally moves towards the slot with increasing NPR however is not monotonic due to shock interactions and changing shock cell length. This behaviour warrants further investigation in co-flow experiments.
Ultrafast pulsed laser utilizing broad bandwidth laser glass (2023)

An ultrafast laser uses a Nd-doped phosphate laser glass characterized by a particularly broad emission bandwidth to generate the shortest possible output pulses. The laser glass is composed primarily of P.sub.2 O.sub.5, Al.sub.2 O.sub.3 and MgO, and possesses physical and thermal properties that are compatible with standard melting and manufacturing methods. The broad bandwidth laser glass can be used in modelocked oscillators as well as in amplifier modules.
K-Space Weighted Acquisition for High-Resolution Imaging (2012)

Purpose/Introduction: K-space weighting by acquiring different numbers of averages depending on position in k-space [1,2] is a well-known and oftenused technique to avoid signal contamination due to the the unfavorable shape of the point-spread function (PSF) in chemical shift imaging. In addition, it is well-known that this technique can improve the apparent SNR by avoiding negative signal contributions from other regions of the sample [3]. This advantage, however, has so far barely been used in imaging, mainly because it requires averaging [4]. For high-resolution images, where averaging is anyway necessary for SNR reasons, k-space weighted acquisition can help to improve resolution and SNR without sacrificing scan time. Subjects and Methods: To demonstrate the SNR gain that is possible by kspace weighted acquisition, a 3D-FLASH sequence with weighting in both phase encode directions was implemented. The scheme of the radial weighting function was adjusted to yield equal resolution in the same scan time as a standard FLASH sequence with otherwise identical parameters. Results: Figure 1 shows a comparison of PSFs of the weighted and unweighted sequences. While the width of the PSF is equal in both cases, implying equal spatial resolution, signal contributions from outside the voxel are strongly suppressed by weighted acquisition, resulting in reduced Gibbs-ringing and improved apparent SNR. Discussion/Conclusion: For high-resolution imaging, where averaging is required for SNR-reasons, k-space weighted acquisition can help to significantly improve SNR and image quality with no extra cost in scan time.
T cell clones specific for p21 ras‐derived peptides: Characterization of their fine specificity and HLA restriction (1993)

Peptides corresponding to the mutated regions of the oncoprotein p21 ras are immunogenic and capable of eliciting HLA class II-restricted T cell responses. Here we report studies on the fine specificity of four T lymphocyte clones (TLC) from a single donor, using various truncated peptides derived from the residues 6-19 of p21 ras and a panel of well-characterized HLA homozygous cells as antigen-presenting cells. Putative minimum peptides of nine or ten amino acids could be defined for each TLC. Two of the TLC recognized peptides presented by DR2, and the two others recognized peptides presented by DQ6. Some notable differences in the requirement for certain amino acids were seen between the DR- and DQ-restricted TLC. Thus, Ser at residue 17 was required for stimulation of the DQ6-but not the DR2-restricted TLC. Val at residue 8 was essential for stimulation of all TLC, whereas one of the DR2-restricted TLC also required Val at residue 7. Some peptides which were nonstimulatory were still capable of binding to DQ6 molecules in peptide competition experiments. The results may be of importance for potential immunotherapy of cancer where transforming ras oncoproteins are involved.
Supporting flexible, extensible task descriptions in and among tasks (1995)

This thesis describes and formalizes Obligations, a model and prototype implementation that supports a continuum of task definitions from unspecified to well specified with dynamic movement of instances along this continuum. When little is known about a task, a simple request can be created that has only a textual description of the goal. If a lot of detail can be predicted about a task's sub-activities and their relationships, templates can be created that define the task's flow. Regardless of the amount of predefined structure, obligations can be modified to add detail, alter the projected path, remove unneeded steps, and align the obligation with the current circumstances.
Our model uses multiple inheritance of templates and an overhead transparency metaphor to construct a network of tasks. Global templates (transparencies) define how a task is expected to proceed while local templates capture changes made to a single instance and not shared with other similar tasks. When an obligation's templates are stacked together, they create a composite view of the network. Templates are treated as meta-objects. Modifications to either the global or local templates can change the network by replacing the current template with a newly upgraded template. This type of replacement can be encoded into surrogates which automatically execute the replacements to keep the obligation up-to-date. Of course, when dynamic changes are allowed, there is the possibility of errors. The Obligation system has built in error detection schemes that determine if network construction is invalid and, when errors occur, alerts the participants and disallows execution of the network portions that are in error.
In addition, since webs of interdependencies evolve among tasks in a fashion which is sometimes predictable, but often completely ad hoc, Obligations allow users to specify requests that span among collaborative contexts. When relationships are predictable, task specifications can be written that automatically spawn an obligation. When the obligation completes, the task is notified and can execute appropriate actions. When relationships are ad hoc, users are able to connect two or more tasks together, by hand, using an obligation. These bridging obligations can be used to migrate commands and to traverse into other collaborative contexts.
First demonstration of FinFET split-gate MONOS for high-speed and highly-reliable embedded flash in 16/14nm-node and beyond (2016)

FinFET split-gate metal-oxide nitride oxide silicon (SG-MONOS) Flash memories have been fabricated and operated for the first time. Excellent subthreshold characteristics and small threshold-voltage variability owing to a Fin-structure are clarified. It is demonstrated that Fin top-corner effects are well suppressed by incremental step pulse programming for source side injection. Highly reliable data retention at 150 °C after 250K program/erase cycles is confirmed for advanced automotive system applications.
Ribonuclease E Modulation of the Bacterial SOS Response (2012)

Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction pathway that transcriptionally derepresses a multiplicity of genes-leading to transient arrest of cell division and initiation of DNA repair. Here we report the previously unsuspected role of E. coli endoribonuclease RNase E in regulation of the SOS response. We show that RNase E deletion or inactivation of temperature-sensitive RNase E protein precludes normal initiation of SOS. The ability of RNase E to regulate SOS is dynamic, as down regulation of RNase E following DNA damage by mitomycin C resulted in SOS termination and restoration of RNase E function leads to resumption of a previously aborted response. Overexpression of the RraA protein, which binds to the C-terminal region of RNase E and modulates the actions of degradosomes, recapitulated the effects of RNase E deficiency. Possible mechanisms for RNase E effects on SOS are discussed.
Data from Hypoxia-Reoxygenation Couples 3βHSD1 Enzyme and Cofactor Upregulation to Facilitate Androgen Biosynthesis and Hormone Therapy Resistance in Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Androgen deprivation therapy suppresses tumor androgen receptor (AR) signaling by depleting circulating testosterone and is a mainstay treatment for advanced prostate cancer. Despite initial treatment response, castration-resistant prostate cancer nearly always develops and remains driven primarily by the androgen axis. Here we investigated how changes in oxygenation affect androgen synthesis. In prostate cancer cells, chronic hypoxia coupled to reoxygenation resulted in efficient metabolism of androgen precursors to produce androgens and activate AR. Hypoxia induced 3βHSD1, the rate-limiting androgen synthesis regulator, and reoxygenation replenished necessary cofactors, suggesting that hypoxia and reoxygenation both facilitate potent androgen synthesis. The EGLN1/VHL/HIF2α pathway induced 3βHSD1 expression through direct binding of HIF2α to the 5′ regulatory region of &lt;i&gt;HSD3B1&lt;/i&gt; to promote transcription. Overexpression of HIF2α facilitated prostate cancer progression, which largely depended on 3βHSD1. Inhibition of HIF2α with the small-molecule PT2399 prevented prostate cancer cell proliferation. These results thus identify HIF2α as a regulator of androgen synthesis and potential therapeutic target in prostate cancer.&lt;/p&gt;Significance:&lt;p&gt;Hypoxia followed by reoxygenation in prostate cancer drives androgen deprivation therapy resistance via increasing the rate-limiting enzyme and cofactors for androgen synthesis, revealing HIF2α as a therapeutic target to subvert resistance.&lt;/p&gt;&lt;/div&gt;
Tympanic Membrane Collagen Fibers: A Key to High‐Frequency Sound Conduction (2008)

Radial collagen fibers in the tympanic membrane play an important role in the conduction of sound above 4 kHz.
Crimping and deployment of balloon-expandable valved stents are responsible for the increase in the hydraulic conductance of leaflets (2013)

The determination of the hydraulic conductance of pericardial patches was easy to perform, reproducible and not influenced by tissue thickness. The hydraulic conductance of pericardial leaflets dramatically increased after VS crimping and deployment. This parameter might be, in the future, a useful noninvasive tool in studying leaflet trauma.
Waterjet Peening At 600MPa: A First Investigation (2005)

An experimental study was conducted to explore the high-pressure waterjet (WJ) peening at 600MPa on the surface integrity and texture of metals. The concept of larger droplet size and multiple droplet impacts resulting from an ultra high-pressure waterjet (UHPWJ) was used to explore and develop the peening process. A combination of microstructure analysis, microhardness measurements, and profilometry were used in determining the depth of plastic deformation and surface texture that result from the surface treatment process. It was found that waterjet peening at 600MPa induces plastic deformation to greater depths in the sub-surface layer of metals than laser shock peening. The degree of plastic deformation and the state of material surface were found to be strongly dependent on the peening conditions and desired surface roughness. Based on these first investigation results, water peening at 600MPa may serve as a new method for introducing compressive residual stresses in engineering components.
3D continuous emission and spiral transmission scanning for high-throughput whole-body PET (2005)

In order to achieve high-throughput whole-body PET studies, we have developed 3D continuous emission and spiral transmission (CEST) scanning for a newly developed PET scanner: SET-3000G/X. In this method, the patient couch moves continuously through the emission and dedicated transmission scanners separated axially by a lead shield. Transmission single data are acquired with a rotating <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs point source as spiral fan-beam data with emission singles contamination correction. These data are sequentially rebinned and reconstructed to estimate 3D attenuation table for 511 keV photons. Emission 3D coincidence data are acquired in histogram mode with on-the-fly attenuation correction and Fourier rebinning at each axial sampling. Attenuation corrected 3D emission images can then be obtained in a single continuous bed movement. The CEST acquisition has the potential of reducing whole body acquisition times significantly while improving the data processing efficiency
Dense FPGA Compute Using Signed Byte Tuples (2021)

The importance of AI to FPGA has resulted in ever increasing low precision hard arithmetic features in newer devices. Many FPGAs, including those from Achronix, Intel, and Xilinx, have significantly increased the density of INT8 and INT9 embedded multipliers. Mainstream devices with these enhanced densities still support the traditional intermediate integer (typically 18-bit) multipliers, with IEEE-754 floating-point now becoming more prevalent as well.Recently, Intel introduced the Stratix 10 NX FPGA, which is targeted specifically at AI acceleration. This device contains a new type of AI-specific DSP Block with approximately an order of magnitude higher INT8 density than previous FPGA industry DSP Blocks. Larger standard FPGA integer precisions, however, are not directly supported. Intel has described some methods of aggregating larger multipliers from the NX Blocks, but these are somewhat smaller than typically used by DSP applications. Larger multiplications can also be useful for other AI applications, such as found in training. In this paper, we introduce the concept of signed tuples, which can be used to assemble signed multipliers into more useful larger precision multipliers by leveraging FPGA soft-logic inexpensively. We demonstrate several constructions of INT16 multipliers, with some modes requiring less than 3 ALMs per INT16 multiplier when implemented in a tensor format. We also describe the application of these methods to even larger multipliers and alternate constructs such as complex multiplication. We show that there is essentially no performance degradation or system fitting impact from our method. The mid-size NX device can support up 33 TOPs INT16 (from 29,700 constructed INT16 multipliers on a mid-speed grade device) with this approach, which is higher than any other current or announced monolithic die FPGA. Our methods are not limited to FPGA, or any particular starting precision, and so may be used for other aggregations as well.
Networking Architecture for Seamless Cloud Interoperability (2015)

Seamless cloud interoperability is highly desired but not yet easily attainable in the current cloud solutions market. This work tackles one aspect of achieving cloud interoperability, namely, inter-cloud networking. We list the requirements and propose an inter-cloud networking architecture for a case of independent clouds owned by different entities and powered by different cloud management and network virtualization technologies. Then we validate the proposed architecture by describing an example of working implementation for Open Stack cloud powered by Open Daylight Open DOVE SDN solution. Finally, we compare our architecture to the existing solutions.
Association Between Prostate Cancer and 25-Hydroxyvitamin D2 Levels: National Health and Nutrition Examination Survey 2007−2008 Results (2020)

To report an association between prostate cancer and vitamin D levels among different races in a single population in the United States. Materials and Methods: We investigated whether there was an association between vitamin D level and prostate cancer in different races in the United States. We used data collected from 1,363 men during the National Health and Nutrition Examination Survey 2007-2008. Multivariate logistic regression analysis was used to evaluate the independent associations between vitamin D levels (not only 25-hydroxyvitamin D [25(OH)D], but also 25(OH)D2 and D3) and prostate cancer. Association between vitamin D levels and prostate specific antigen level was also analyzed in non-Hispanic white males without prostate cancer. Results: Older age was significantly associated with prostate cancer in all races (p0.05), whereas vitamin D (p=0.024), especially 25(OH)D2 (p=0.027) was significantly higher only in non-Hispanic white males. There was no difference in vitamin D levels between non-Hispanic white males with a prostate specific antigen concentration 3 ng/mL and 3 ng/mL. Conclusions: This study revealed a positive association between vitamin D, especially 25(OH)D2, and prostate cancer only in non-Hispanic white males. And vitamin D was not associated with prostate specific antigen level causing detection bias. (