gebhart/patrepeval huggingface dataset:
Frequency-Multiplexed Array Digitization for MIMO Receivers: 4-Antennas/ADC at 28 GHz on Xilinx ZCU-1285 RF SoC (2021)

Communications at mm-wave frequencies and above rely heavily on beamforming antenna arrays. Typically, hundreds, if not thousands, of independent antenna channels are used to achieve high SNR for throughput and increased capacity. Using a dedicated ADC per antenna receiver is preferable but it's not practical for very large arrays due to unreasonable cost and complexity. Frequency division multiplexing (FDM) is a well-known technique for combining multiple signals into a single wideband channel. In a first of its kind measurements, this paper explores FDM for combining multiple antenna outputs at IF into a single wideband signal that can be sampled and digitized using a high-speed wideband ADC. The sampled signals are sub-band filtered and digitally down-converted to obtain individual antenna channels. A prototype receiver was realized with a uniform linear array consisting of 4 elements with 250 MHz bandwidth per channel at 28 GHz carrier frequency. Each of the receiver chains were frequency-multiplexed at an intermediate frequency of 1 GHz to avoid the requirement for multiple, precise local oscillators (LOs). Combined narrowband receiver outputs were sampled using a single ADC with digital front-end operating on a Xilinx ZCU-1285 RF SoC FPGA to synthesize 4 digital beams. The approach allows $M$ -fold increase in spatial degrees of freedom per ADC, for temporal oversampling by a factor of $M$.
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors (2021)

Herein the discovery of potent IDO1 inhibitors with low predicted human dose is discussed. Metabolite identification (MetID) and structural data were used to strategically incorporate cyclopropane rings into this tetrahydronaphthyridine series of IDO1 inhibitors to improve their metabolic stability and potency. Enabling synthetic chemistry was developed to construct these unique fused cyclopropyl compounds, leading to inhibitors with improved pharmacokinetics and human whole blood potency and a predicted human oral dose as low as 9 mg once daily (QD).
The Roles of Structural Order and Intermolecular Interactions in Determining Ionization Energies and Charge‐Transfer State Energies in Organic Semiconductors (2016)

The energy landscape in organic semiconducting materials greatly influences charge and exciton behavior, which are both critical to the operation of organic electronic devices. These energy landscapes can change dramatically depending on the phases of material present, including pure phases of one molecule or polymer and mixed phases exhibiting different degrees of order and composition. In this work, ultraviolet photoelectron spectroscopy measurements of ionization energies (IEs) and external quantum efficiency measurements of charge‐transfer (CT) state energies ( E CT ) are applied to molecular photovoltaic material systems to characterize energy landscapes. The results show that IEs and E CT values are highly dependent on structural order and phase composition. In the sexithiophene:C 60 system both the IEs of sexithiophene and C 60 shift by over 0.4 eV while E CT shifts by 0.5 eV depending on molecular composition. By contrast, in the rubrene:C 60 system the IE of rubrene and C 60 vary by ≤ 0.11 eV and E CT varies by ≤ 0.04 eV as the material composition varies. These results suggest that energy landscapes can exist whereby the binding energies of the CT states are overcome by energy offsets between charges in CT states in mixed regions and free charges in pure phases.
Structural Analysis of an N-Glycan with “β1−4 Bisecting Branch” from Human Serum IgG by Negative-Ion MSn Spectral Matching and Exoglycosidase Digestion (2005)

A novel N-linked oligosaccharide (N-glycan) with “β1−4 bisecting branch (galactose β1−4 bisecting N-acetylglucosamine)” was found in human serum IgG. Its structure was efficiently analyzed by using β-galactosidase digestion, a MSn spectral library database, and negative-ion MS2 spectral matching. For confirmation, the novel N-glycan was synthesized by using an expected standard N-glycan (acceptor), UDP-galactose (donor), and β1−4 galactosyltransferase. This work also demonstrates that the MSn spectral library database, in particular, negative-ion MS2 spectral matching, can efficiently reduce the number of specific, sequential exoglycosidase digestions required and is useful for rapid structural analysis of unknown glycans not in the database.
Matisse: a system-on-chip design methodology emphasizing dynamic memory management (2002)

Matisse is a design environment intended for developing systems characterized by a tight interaction between control and data-flow behavior, intensive data storage and transfer and stringent real-time requirements. Matisse bridges the gap from a system specification, using a concurrent object-oriented language, to an optimized embedded single-chip hardware/software implementation. Matisse supports stepwise exploration and refinement of dynamic memory management, memory architecture exploration, and gradual incorporation of timing constraints before going to traditional tools for hardware synthesis, software compilation, and inter-processor communication synthesis. With this approach, specifications of embedded systems can be written in a high-level programming language using data abstraction. Application of Matisse on telecom protocol processing systems in the ATM area shows significant improvements in area usage and power consumption.
Effect of Somatostatin on Duodenal Glucose Absorption in Man (2005)

These properties of SST hamper the use of intraduodenal hyperglycemic hyperinsulinemic clamps as a tool for exploring postprandial glucose metabolism.
PUTATIVE MECHANISMS OF SILDENAFIL'S PREVENTION OF PRIAPISM IN TRANSGENIC SICKLE CELL MICE: ROLE OF eNOS UNCOUPLING AND PHOSPHORYLATION (2008)

You have accessJournal of Urology1 Apr 2008PUTATIVE MECHANISMS OF SILDENAFIL'S PREVENTION OF PRIAPISM IN TRANSGENIC SICKLE CELL MICE: ROLE OF eNOS UNCOUPLING AND PHOSPHORYLATION Trinity J Bivalacqua, Biljana Musicki, Hunter C Champion, and Arthur L Burnett Trinity J BivalacquaTrinity J Bivalacqua More articles by this author , Biljana MusickiBiljana Musicki More articles by this author , Hunter C ChampionHunter C Champion More articles by this author , and Arthur L BurnettArthur L Burnett More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60811-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PUTATIVE MECHANISMS OF SILDENAFIL'S PREVENTION OF PRIAPISM IN TRANSGENIC SICKLE CELL MICE: ROLE OF eNOS UNCOUPLING AND PHOSPHORYLATION." The Journal of Urology, 179(4S), p. 279 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 279 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetrics Author Information Trinity J Bivalacqua More articles by this author Biljana Musicki More articles by this author Hunter C Champion More articles by this author Arthur L Burnett More articles by this author Expand All Advertisement PDF downloadLoading ...
STUDIES OF MOUSE POLYOMA VIRUS INFECTION (1959)

Treatment of guinea pig erythrocytes with types A and B influenza viruses rendered them inagglutinable by polyoma virus; also, the inhibitory effect of ovomucin on polyoma virus hemagglutination was destroyed by pretreatment of the ovomucin with various myxoviruses. These results indicate that polyoma virus and myxovirus erythrocyte receptor sites are identical. However, no destruction by polyoma virus of its own or of myxovirus receptors or inhibitors was detected. No serologic relationship was detected between polyoma virus and members of the myxovirus group; differences in size and stability further indicate their distinctness. No evidence was found of biologic or serologic relationship of polyoma virus with encephalomyocarditis virus or mouse encephalomyelitis virus.
Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice (2014)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Indolmycin Resistance of Streptomyces coelicolor A3(2) by Induced Expression of One of Its Two Tryptophanyl-tRNA Synthetases (2002)

Aminoacyl-tRNA synthetases, a family of enzymes essential for protein synthesis, are promising targets of antimicrobials. Indolmycin, a secondary metabolite of Streptomyces griseus and a selective inhibitor of prokaryotic tryptophanyl-tRNA synthetase (TrpRS), was used to explore the mechanism of inhibition and to explain the resistance of a naturally occurring strain. Streptomyces coelicolor A3(2), an indolmycin-resistant strain, contains two trpS genes encoding distinct TrpRS enzymes. We show that TrpRS1 is indolmycin-resistant in vitro and in vivo, whereas TrpRS2 is sensitive. The lysine (position 9) in the enzyme tryptophan binding site is essential for making TrpRS1 indolmycin-resistant. Replacement of lysine 9 by glutamine, which at this position is conserved in most bacterial TrpRS proteins, abolished the ability of the mutant trpS gene to confer indolmycin resistance in vivo. Molecular modeling suggests that lysine 9 sterically hinders indolmycin binding to the enzyme. Tryptophan recognition (assessed by k(cat)/K(M)) by TrpRS1 is 4-fold lower than that of TrpRS2. Examination of the mRNA for the two enzymes revealed that only TrpRS2 mRNA is constitutively expressed, whereas mRNA for the indolmycin-resistant TrpRS1 enzyme is induced when the cells are exposed to indolmycin.
Proteoglycan 4 and hyaluronan as boundary lubricants for model contact lens hydrogels (2017)

Clinical data show that in vitro contact lens friction is related to in vivo comfort. Solutions of biological lubricants hyaluronan (HA) and proteoglycan 4 (PRG4, also known as lubricin) reduce friction at a cornea-polydimethylsiloxane (PDMS) interface. The purpose of this study was to (1) determine if PRG4 can sorb to and lubricate model contact lens materials and (2) assess the boundary lubricating ability of PRG4 and HA compared to saline on model contact lens materials. PRG4 was obtained from bovine cartilage culture and suspended in saline at 300 µg/mL. N,N-Dimethylacrylamidetris (trimethylsiloxy) silane, (DMAA/TRIS) and methacryloxypropyltris (trimethylsiloxy) silane (pHEMA/TRIS) silicone hydrogels were prepared. A previously described in vitro eyelid-hydrogel and cornea-hydrogel biomechanical friction test was used to determine boundary lubricant effect. PRG4 sorption to the hydrogels was assessed using a soak-rinse protocol and western blotting. PRG4 effectively lubricated both silicone hydrogel materials and HA effectively lubricated pHEMA/TRIS, as indicated by a statistically significant reduction in friction compared to the saline control lubricant. An HA and PRG4 combination showed a synergistic effect for pHEMA/TRIS and effectively lubricated DMAA/TRIS. Biological boundary lubricants HA and PRG4 were shown to effectively lubricate silicone hydrogels when in solution. Additionally, HA and PRG4 showed synergistic lubrication for pHEMA/TRIS. The purpose of this study was not to replicate the friction coefficients of contact lenses, but rather to investigate lubricant-surface interactions for common contact lens constituents. These findings contribute to the potential development of biomolecule based lubricant drops for contact lens wearers. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1329-1338, 2018.
An extended library of models of railway vehicles for fast simulation and optimization of regenerative braking and energy management (2016)

As a part of the Tesys Rail Project authors have developed a parametric and computationally affordable model of a railway DC line in order to analyze the complex energetic interactions arising between different travelling vehicles. In order to fully exploit the features of the proposed approach and its capability to investigate complex operating scenarios, the authors have further developed the model by including a wider variety of on-board functionalities and a more extended list of simulated vehicles. In this research work, the authors expose some improvements of a previously developed High Speed train model (based on the ETR 1000) and the development of additional models of older Italian High Speed Trains, such as the ETR 500, which are still in service on Italian High Speed lines.
Extracellular vesicle measurements with nanoparticle tracking analysis – An accuracy and repeatability comparison between NanoSight NS300 and ZetaView (2019)

The expanding field of extracellular vesicle (EV) research needs reproducible and accurate methods to characterize single EVs. Nanoparticle Tracking Analysis (NTA) is commonly used to determine EV concentration and diameter. As the EV field is lacking methods to easily confirm and validate NTA data, questioning the reliability of measurements remains highly important. In this regard, a comparison addressing measurement quality between different NTA devices such as Malvern's NanoSight NS300 or Particle Metrix' ZetaView has not yet been conducted. To evaluate the accuracy and repeatability of size and concentration determinations of both devices, we employed comparative methods including transmission electron microscopy (TEM) and single particle interferometric reflectance imaging sensing (SP-IRIS) by ExoView. Multiple test measurements with nanospheres, liposomes and ultracentrifuged EVs from human serum and cell culture supernatant were performed. Additionally, serial dilutions and freeze-thaw cycle-dependent EV decrease were measured to determine the robustness of each system. Strikingly, NanoSight NS300 exhibited a 2.0-2.1-fold overestimation of polystyrene and silica nanosphere concentration. By measuring serial dilutions of EV samples, we demonstrated higher accuracy in concentration determination by ZetaView (% BIAS range: 2.7-8.5) in comparison with NanoSight NS300 (% BIAS range: 32.9-36.8). The concentration measurements by ZetaView were also more precise (% CV range: 0.0-4.7) than measurements by NanoSight NS300 (% CV range: 5.4-10.7). On the contrary, quantitative TEM imaging indicated more accurate EV sizing by NanoSight NS300 (% D<sub>TEM</sub> range: 79.5-134.3) compared to ZetaView (% D<sub>TEM</sub> range: 111.8-205.7), while being equally repeatable (NanoSight NS300% CV range: 0.8-6.7; ZetaView: 1.4-7.8). However, both devices failed to report a peak EV diameter below 60 nm compared to TEM and SP-IRIS. Taken together, NTA devices differ strongly in their hardware and software affecting measuring results. ZetaView provided a more accurate and repeatable depiction of EV concentration, whereas NanoSight NS300 supplied size measurements of higher resolution.
Nutritional strategies for correcting low glucose values in patients with postbariatric hypoglycaemia: A randomized controlled three‐arm crossover trial (2023)

NTC05250271 (ClinicalTrials.gov).
Development and experimental validation of a thermo-hydraulic model for data centers (2011)

Abstract Most data center design analyses focus on design point operation, which, in reality, is rarely realized due to the reliability needs and the constantly changing operating states of data centers. The objective of this work is to develop and experimentally validate a model that will allow data center operators and designers the ability to evaluate the energy impact of various data center loop configurations and operating strategies. The modeling methodology couples a thermodynamic model of the cooling equipment and a hydraulic pipe network for hydraulic characterization. Inherent in this model is the ability to capture off-design operating conditions of the data center cooling infrastructure caused by changes in ambient conditions and fluctuations in required IT load. The thermo-hydraulic model is validated based on an existing IT data center and chiller plant located in Poughkeepsie, New York. The model is used to study the data center under several climatic and operating conditions—namely, winter and summer. The resulting performance in terms of the ratio of the total facility power to the IT power usage effectiveness was found to be 1.57 and 1.73, respectively, for the two climatic and operating modes. Acknowledgments Dustin W. Demetriou, Student Member ASHRAE, is PhD Candidate. H. Ezzat Khalifa, PhD, Fellow ASHRAE, is NYSTAR Distinguished Professor. Madhusudan Iyengar, PhD, Member ASHRAE, is Senior Engineer. Roger R. Schmidt, PhD, PE, Member ASHRAE, is IBM Fellow and Chief Engineer.
Per-se Privacy Preserving Solution Methods Based on Optimization (2013)

Ensuring privacy is an essential requirement in various contexts, such as social networks, healthcare data, e- commerce, banks, and government services. Here, different en- tities coordinate to address specific problems where the sensitive problem data are distributed among the involved entities and no entity wants to publish its data during the solution procedure. Existing privacy preserving solution methods are mostly based on cryptographic procedures and thus have the drawback of substantial computational complexity. Surprisingly, little atten- tion has been devoted thus far to exploit mathematical opti- mization techniques and their inherent properties for preserving privacy. Yet, optimization based approaches to privacy require much less computational effort compared to cryptographic variants, which is certainly desirable in practice. In this paper, a unified framework for transformation based optimization methods that ensure privacy is developed. A general definition for the privacy in the context of transformation methods is proposed. A number of examples are provided to illustrate the ideas. It is concluded that the theory is still in its infancy and that huge benefits can be achieved by a substantial development.
Responsive Algorithms for Defending Recon gurable Networks (2008)

We present algorithms to self-heal reconfigurable networks when they are under attack. These algorithms reconfigure the network during attack to protect two critical invariants. First, they insure that the network remains connected. Second, they insure that no node increases its degree by more than O(log n). We show both theoretically and empirically that our algorithms can successfully maintain these invariants even for large networks under massive attack by a computationally unbounded adversary.
Peritoneal Dialysis in Patients with Refractory Congestive Heart Failure: A Systematic Review (2015)

This systematic review suggests that PD may be an effective and safe therapeutic tool for patients with RCHF.
Site-Specific Water and Chemical Application by Wireless Valve Controller Network (2008)

Variations in plant water and nutrient demand and environmental regulations to protect water quality provide significant justification for development of site-specific irrigation and fertigation systems. We have developed wireless valve controllers that self-assemble into a mesh network. Mesh networking means that controllers pass messages to extend the effective communication range without using high power radios. Solar energy is collected with a 200 mW panel to operate each controller node without yearly battery replacement. Nine nodes were tested in a mesh network and each properly responded to commands. Measurements of battery voltage, solar panel voltage, enclosure temperature, and external sensors were transmitted every 10 minutes. Irrigation schedules were stored locally on each node and executed automatically. Schedules for each node were unique, based on the needs of the particular area being irrigated. Internal clock drift was an average 6.3 s per day. Clock offset was removed using daily time stamps. One-hop transmission range using 916 MHz radios varied from 20.9 m with a whip antenna at ground level to 241.1 m with a dipole antenna mounted at 3 m. Node commands were acknowledged after an average of 2.7 s per hop. Daily charge consumption was approximately 6.76 mAh for the node and 1 mAh per day for battery self-discharge. The solar panel produced 26.0 to 81.3 mAh in direct sunlight and 6.5 to 13.7 mAh in shade. Node operation is expected to be continuous with occasional sunlight exposure. Soil moisture, pressure, temperature, and other environmental sensors will be used for feedback control and detection of problems. Such a network of intelligent valve controllers will allow growers in orchards, vineyards, nurseries, greenhouses, and landscapes to develop management practices that improve water and fertilizer use efficiency.
Broadband enhancement of spontaneous emission from nitrogen-vacancy centers in nanodiamonds by hyperbolic metamaterials (2013)

We experimentally demonstrate a broadband enhancement of emission from nitrogen-vacancy centers in nanodiamonds. The enhancement is achieved by using a multilayer metamaterial with hyperbolic dispersion.
Stereoblock Macromolecule (2016)

In the past, aggregation and self-assembly have been associated principally with micellar and colloidal systems of molecules; however, with the advent of supramolecular chemistry, molecular self-assembly has been opened to a much wider understanding that has facilitated access to a variety of different shapes and sizes, along with the construction of new and fascinating molecular topologies. This document aims at defining more than 150 terms related to aggregation and self-assembly in the particular case of macromolecules. The list is restricted to the most commonly encountered terms.
Maximum-likelihood calibration of an x-ray computed tomography system (2010)

We present a maximum-likelihood (ML) method for calibrating the geometrical parameters of an x-ray computed tomography (CT) system. This method makes use of the full image data and not a reduced set of data. This algorithm is particularly useful for CT systems that change their geometry during the CT acquisition, such as an adaptive CT scan. Our ML search method uses a contracting-grid algorithm that does not require initial starting values to perform its estimate, thus avoiding problems associated with choosing initialization values.
Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples (2022)

To assure reliable results, we recommend avoiding the block surface portion and restricting mutation detection to genomic regions of high confidence.
Contribution à l'inventaire des Pézizales (Fungi, Ascomycota) du Lyonnais - Premier addendum (2014)

Dans le cadre de l'inventaire des Pézizales du département du Rhône, l'auteur propose une liste de taxons nouvellement enregistrés, venant compléter le catalogue actuel.