gebhart/patrepeval huggingface dataset:
NIR-sensitized hybrid radical and cationic photopolymerization of several cyanines in combination with diaryliodonium bis(trifluoromethyl)sulfonyl imide (2022)

A series of cyanines exhibiting absorption between 750 and 930 nm reacted after NIR excitation with the bis( t -butylphenyl) iodonium cation comprising the [(CF3SO2)2N]− anion (NTf 2 ) − , resulting in the generation of free radicals and conjugate acids.
Introducing TE Metrics to account for Transponder and Grooming Resources in GMPLS Multi-layer Networks (2010)

Novel GMPLS TE Metric extensions are proposed to account for the availability of grooming and transponder resources. Advanced grooming policies exploiting these TE metrics are implemented yielding significant improvements of link usage and blocking probability.
Cavity Attenuated Phase Shift (CAPS)-Based Detection of Gas Phase Species and Aerosols (2019)

We describe the use of state-of-the-art monitors that measure both the concentration of nitrogen dioxide and the optical properties of aerosols using Cavity Attenuated Phase Shift (CAPS) techniques. Inc.
Tuning of Laser Frequency in Random Media of Dye-Doped Polymer and Glass-Particle Hybrid (2003)

We prepared a solid-state random medium as a laser source consisting of laser-dye-doped polymer and glass-particle scatterers. The random medium was prepared by dispersing glass particles in polymer medium by laser-induced glass ablation. The gain medium emitted single-mode laser light that had a 0.15 nm spectral linewidth. The lasing action was based on the coherent feedback resulting from the strong optical scattering and was characterized in terms of the random laser. Our experimental results suggest that the spatial confinement of emitted light at certain wavelengths results in the fine tuning of the lasing frequency.
Ultrafast pulse shaping with a traveling wave Kerr cell and picosecond rise time electrical pulses (1979)

A traveling wave CS(2) Kerr cell has been used to shape optical pulses at 1.06 microm. The rise time of ~20 psec reported here is possiile because the group velocities for electrical and optical pulses are equal in CS(2) at 1.06 microm. An electrical pulse generated by a light activated semiconductor switch is used to drive the device. High contrast jitter-free operation appears to be possible.
O1–06–03: Efficacy and safety of the alpha7 agonist ABT‐126 in mild‐to‐moderate Alzheimer's dementia (2013)

ABT-126, a novel α7 neuronal nicotinic receptor agonist, was evaluated for procognitive effects in mild-to-moderate Alzheimer's dementia patients. This randomized, double-blind, placebo- and active-controlled, multi-center Phase 2 study targeted enrollment of 260 subjects with mild-to-moderate Alzheimer's dementia (Mini-Mental Status Examination [MMSE] score of 10–24, inclusive). Subjects not currently receiving acetylcholinesterase inhibitors were randomized to ABT-126 (low or high dose QD), donepezil 10 mg QD, or placebo for 12 weeks. The primary efficacy endpoint was the change from baseline to final evaluation in the 11-item Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) total score. The primary endpoint was analyzed by ANCOVA using factors of treatment and site with baseline score as a covariate. The relationship between ABT-126 plasma exposure and change in ADAS-Cog score was evaluated. Adverse events (AEs), vital signs, ECG, and laboratory results were monitored. The study randomized 274 patients with mean (SD) age of 73.9 (7.9) years. The mean (SD) baseline MMSE was 19.1 (3.8) and did not differ across treatment groups. Seventeen (6.2%) subjects prematurely discontinued (no significant difference across treatment groups), including 9 (3.3%) due to AEs (placebo: 2.9%; low-dose ABT-126: 1.5%; high-dose ABT-126: 1.4%; donepezil: 7.4%). High-dose ABT-126 showed a trend toward improvement on the 11-item ADAS-Cog (LS mean [SE] difference from placebo = -1.19 [0.90], P =0.095); donepezil performed similarly (-1.43 [0.90], P =0.057), demonstrating adequate assay sensitivity. Low-dose ABT-126 yielded similar results to placebo. Exposure-response analyses suggested that higher ABT-126 exposures were associated with greater improvement on the ADAS-Cog (P<0.05). Among treatment groups, there were no clinically meaningful changes in laboratory, vital sign or ECG values, and AEs were similar. For AEs reported most frequently (≥3%) in all ABT-126 treated subjects and at rates higher than placebo, incidence were (placebo, ABT-126, donepezil): diarrhea (2.9%, 4.3%, 7.4%), fall (1.5%, 4.3%, 2.9%), urinary tract infection (0, 4.3%, 4.4%), headache (1.5%, 3.6%, 5.9%), and nausea (1.5%, 3.6%, 8.8%). ABT-126 had an adequate safety profile in subjects with mild-to-moderate Alzheimer's dementia. High-dose ABT-126 improved ADAS-Cog scores similarly to donepezil, and the ADAS-Cog improvement correlated significantly with ABT-126 plasma exposure.
Effects of Pulsatile Blood Flow on Oxygenator Performance (2018)

Extracorporeal membrane oxygenation (ECMO) is mainly used for the therapy of acute respiratory distress syndrome and chronic obstructive lung disease. In the last years, the development of these systems underwent huge steps in optimization, but there are still problems with thrombus formation, clogging, and thus insufficient gas exchange. One idea of ECMO optimization is a pulsatile blood flow through the oxygenator, but this is still a controversy discussion. Analyzing available publications, it was not possible to identify a general statement about the effect of pulsatile blood flow on the gas exchange performance. The variety of parameters and circuit components have such a high influence on the outcome that a direct comparison of the studies is difficult. For this reason, we performed a structured study to evaluate the effects of pulsatile blood flow on the gas exchange performance of oxygenator. In in vitro tests according to DIN EN ISO 7199, we tested a small oxygenator (0.25 m<sup>2</sup> exchange surface, polymethylpentene fibers, 33 mL priming volume) with constant and pulsatile blood flow in comparison. Therefore, we varied the mean blood flow from 250 to 1200 mL/min, the amplitude of 0, 20, and 50%, and the frequency of 30, 60, and 90 bpm. The results demonstrate that the gas transfer for pulsatile and constant blood flow was similar (oxygen: 36-64 mL<sub>O2</sub> /L<sub>Blood</sub> ; carbon dioxide 35-80 mL<sub>CO2</sub> /L<sub>Blood</sub> ) for the same mean blood flow ranges. Over all, the results and analyses showed a statistically nonsignificant difference between pulsatile and nonpulsatile flow. Consequently, we conclude that the implementation of pulsatile blood flow has only a small to no effect on the gas exchange performance in an oxygenator. As the results were obtained using an oxygenator with a coiled fiber bundle, the test must be verified for a stacked fiber oxygenator.
ChemInform Abstract: Ring‐Opening of Enantiomerically Pure Oxa‐Containing Heterocycles with Phosphorus Nucleophiles. (2015)

Abstract Enantiopure epoxide‐ and oxetane‐based substrates undergo regio‐ and stereocontrolled ring‐opening with phosphorus nucleophiles furnishing efficiently 1,2‐ and 1,3‐phosphino alcohols as stable borane complexes.
Critical Coupling Requirements for Surface Plasmon Enhanced Magneto-Optic Isolators (2011)

The critical coupling criteria between dielectric waveguides and lossy surface plasmons is applied to isolator designs. This framework shows that non-reciprocal plasmon-semiconductor waveguides are not achievable, and alternatives are proposed.
Decoder Side Motion Vector Refinement for Versatile Video Coding (2019)

Inter picture prediction is an essential component of today's hybrid video codecs. In order to reduce the bitrate required for motion vector (MV) signaling, the High Efficiency Video Coding (HEVC) standard and the latest Versatile Video Coding (VVC) draft utilize a merge mode to signal the MV. While the merge mode saves the bits for MV indication, it generates inaccurate MVs, which lead to imprecise prediction. To improve the coding performance, novel decoder side motion vector refinement (DMVR) schemes are currently being proposed. The DMVR approach refines the initial MV from the merge mode by searching the block with the smallest matching cost in the previous decoded reference pictures. We present two variants of block matching-based DMVR, namely template matching and bilateral matching. Experimental results obtained with the VTM-2.0 reference software, after integrating our approaches, demonstrate that our proposed methods provide an average luma BD-rate reduction of 4.71% for the template matching-based DMVR and 4.92% for the bilateral matching-based DMVR when using the random access configuration.
Peroneal intraneural ganglia (2007)

✓The authors describe common modes of failure in the diagnosis and treatment of patients with peroneal intraneural ganglia. Illustrated examples correlate the modes of failure and the diagnostic or surgical errors. Understanding these pitfalls reinforces the rationale behind current treatment recommendations as outlined in the companion article. Avoiding these pitfalls will ultimately improve outcomes.
Regional and generalized changes in cytosolic free calcium in monocytes during phagocytosis (1992)

We measured and visualized cytosolic free calcium ([Ca2+]i) in individual human peripheral blood monocytes during phagocytosis by using the fluorescent indicator fura-2. Monocytes exhibit a rapid rise in [Ca2+]i from a basal level of 75 +/- 11 nM to a peak level of 676 +/- 78 nM (means +/- standard errors of the means; P less than 0.001) by 34 +/- 5 s after contact with opsonized zymosan particles, and a thin rim of high [Ca2+]i was observed surrounding the ingested particle.
Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides (2018)

Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escape from membrane-enclosed endocytic organelles to reach target RNAs. We recently found that lysobisphosphatidic acid is required for release of PS-ASOs from late endosomes. Here, we evaluated the effects of other lipids on PS-ASO intracellular trafficking and activities. We show that free fatty acids, ceramide, and cholesterol increase PS-ASO activities. Free fatty acids induced formation of lipid droplets without changing the intracellular localization of PS-ASOs in early or late endosomes. Ceramide and cholesterol did not obviously induce the formation of lipid droplets, but cholesterol caused enlargement of endosome size and volume. Although none of those lipids appeared to influence PS-ASO internalization or intracellular trafficking processes, all led to an increase in leakiness of late endosomes. Thus, the membrane destabilization induced by these lipids likely contributes to PS-ASO release from late endosomes, which, in turn, increases PS-ASO activity.
Supplementary Materials and Methods from Improved Therapeutic Results by Pretargeted Radioimmunotherapy of Non–Hodgkin's Lymphoma with a New Recombinant, Trivalent, Anti-CD20, Bispecific Antibody (2023)

Supplementary Materials and Methods from Improved Therapeutic Results by Pretargeted Radioimmunotherapy of Non–Hodgkin's Lymphoma with a New Recombinant, Trivalent, Anti-CD20, Bispecific Antibody
Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity (2017)

Infant formula with 2'FL and LNnT is safe, well-tolerated, and supports age-appropriate growth. Secondary outcome findings showing associations between consuming HMO-supplemented formula and lower parent-reported morbidity (particularly bronchitis) and medication use (antipyretics and antibiotics) warrant confirmation in future studies.
Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases (2019)

Further studies focusing on young-onset colorectal cancer, particularly with regard to risk factors and establishing the optimal age of screening, are warranted.
A polynomial-time algorithm for pliable index coding (2016)

Pliable index coding considers a server with m messages and n clients where each client has as side information a subset of the messages. We seek to minimize the number of transmissions the server should make, so that each client receives (any) one message she does not already have. Previous work has shown that the server can achieve this using at most O(log <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (n)) transmissions and needs at least Ω(log(n)) transmissions in the worst case, but finding a code of optimal length is NP-hard. In this paper, we design a polynomial-time algorithm that uses less than O(log <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (n)) transmissions, i.e., almost worst-case optimal. We also establish a connection between the pliable index coding problem and the minrank problem over a family of mixed matrices.
Opacity Reduction Using Dry Hydrated Lime Injection (1994)

Abstract This investigation studied the effects of injecting dry hydrated lime into flue gas to reduce sulfur trioxide, (SO3) concentrations and consequently stack opacity at the University of Missouri-Columbia power plant. The opacity was due to sulf uric acid mist forming at the stack from high SO3 concentrations. As a result of light scattering by the mist, a visible plume leaves the stack. Therefore, reducing high concentrations of SO3 reduces the sulfuric acid mist and consequently the opacity. To reduce SO3 concentrations, dry hydrated lime is periodically injected into the flue gas upstream of a baghouse and downstream of an induced draft fan. The hydrated lime is transported downstream by the flue gas and deposited on the filter bags in the baghouse forming a filter cake. The reaction between the SO3 and the hydrated lime takes place on the filter bags. The hydrated lime injection system has resulted in at least 95% reduction in the SO3 concentration and has reduced the opacity to acceptable limits. Low capital equipment requirements, low operating cost, and increased bag life make the system very attractive to industries with similar problems.
Freeform Optical Surfaces: Report from OSA’s First Incubator Meeting (2012)

Just as business incubator programs are designed to support the development of fledgling companies, OSA’s new incubator meeting series is structured to encourage the growth of exciting new areas within optics. The first one was devoted to the topic of freeform optics-a field that is actively evolving due to recent technological advances.
Metabolism and composition of the canine anterior cruciate ligament relate to differences in knee joint mechanics and predisposition to ligament rupture (2004)

The different metabolism of the collagenous matrix in the ACLs of dogs predisposed to rupture was related to greater knee joint laxity and lower ligament material properties (ultimate tensile stress). This may be suggestive of a link between ligament rupture and eventual knee osteoarthritis in both dogs and humans.
ChemInform Abstract: Highly Efficient Cu(I)‐Catalyzed Synthesis of N‐Heterocycles Through a Cyclization‐Triggered Addition of Alkynes. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Validation of a 3D CT imaging method for quantifying implant migration following anatomic total shoulder arthroplasty (2021)

Glenoid component loosening remains a common complication following anatomic total shoulder arthroplasty (TSA); however, plain radiographs are unable to accurately detect early implant migration. The purpose of this study was to validate the accuracy of a method of postoperative, three-dimensional (3D) computed tomography (CT) imaging with metal artifact reduction (MAR) to detect glenoid component migration following anatomic TSA. Tantalum bead markers were inserted into polyethylene glenoid components for implant detection on 3D CT. In-vitro validation was performed using a glenoid component placed into a scapula sawbone and incrementally translated and rotated, with MAR 3D CT acquired at each test position. Accuracy was evaluated by root mean square error (RMSE). In-vivo validation was performed on six patients who underwent anatomic TSA, with two postoperative CT scans acquired in each patient and marker-based radiostereometric analysis (RSA) performed on the same days. Glenoid component migration was calculated relative to a scapular coordinate system for both MAR 3D CT and RSA. Accuracy was evaluated by RMSE and paired Student's t-tests. The largest RMSE on in-vitro testing was 0.24 mm in translation and 0.11° in rotation, and on in-vivo testing was 0.47 mm in translation and 1.04° in rotation. There were no significant differences between MAR 3D CT and RSA measurement methods. MAR 3D CT imaging is capable of quantifying glenoid component migration with a high level of accuracy. MAR 3D CT imaging is advantageous over RSA because it is readily available clinically and can also be used to evaluate the implant-bone interface.
Promises and Challenges in Light-Emitting Diodes for High-Power Lighting Applications (2011)

Lighting technologies based on semiconductor light-emitting diodes (LEDs) offer unprecedented promises that include three major benefits: (i) Gigantic energy savings enabled by efficient conversion of electrical energy to optical energy; (ii) Substantial positive contributions to sustainability through reduced emissions of global-warming gases, acid-rain gases, and toxic substances such as mercury; and (iii) The creation of new paradigms in lighting driven by the unique controllability of solid-state lighting sources. Due to the powerful nature of these benefits, the transition from conventional lighting sources to solid-state lighting is virtually assured. This presentation will discuss one of the formidable challenges of LED technology: The efficiency droop, that is, the decreasing GaInN LED efficiency occurring at high current densities. We will discuss the origin of the efficiency droop as well as ways to reduce the droop.
Application of 31P n.m.r. to inborn errors of muscle metabolism (1983)

Conference Article| December 01 1983 Application of 31P n.m.r. to inborn errors of muscle metabolism B. D. ROSS; B. D. ROSS 1Nuffield Department of Clinical Medicine and of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar G. K. RADDA G. K. RADDA 1Nuffield Department of Clinical Medicine and of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1983) 11 (6): 627–630. https://doi.org/10.1042/bst0110627 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation B. D. ROSS, G. K. RADDA; Application of 31P n.m.r. to inborn errors of muscle metabolism. Biochem Soc Trans 1 December 1983; 11 (6): 627–630. doi: https://doi.org/10.1042/bst0110627 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PCr, phosphocreatine, PFK, phosphofructokinase © 1983 Biochemical Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.
High Conductivity, Lithium Ion Conducting Polymer Electrolyte Based on Hydrocarbon Backbone with Pendent Carbonate (2020)

Solid polymer electrolytes (sPE) offer a pathway for safer, less flammable lithium batteries. However, developing a polymer that provides high Li + mobility as well electrochemical stability remains a challenge, because ion conductive functional units in the polymer main-chain (e.g., polycarbonate and polyether) usually suffer from poor electrochemical stability at high and low potentials. Herein, an sPE with pendent carbonate on a hydrocarbon backbone has been designed and synthesized to overcome conductivity and electrochemical stability problems. This pendant polycarbonate is different from conventional polycarbonate electrolytes because the carbonate moiety is in the sidechain, which mitigates polycarbonate backbone stability problems while still providing high ionic conductivity when used with a plasticizer. Conductivity as high as 1.1 mS cm −1 at 22 °C was obtained. Stable lithium metal plating and stripping using the sPE was observed for 1,200 h and electrochemical stability up to 4.6 V vs Li + /Li has been demonstrated. The low interfacial resistance (&lt;160 ohm∙cm 2 at 22 °C) and reasonable ionic conductivity have enabled acceptable cycling performance in a Li-LiFePO 4 battery at 0.98 mA cm −2 for 2,300 cycles.
Variations in the endogenous fluorescence of rabbit corneas after mechanical property alterations (2017)

Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate the feasibility of using the endogenous fluorescence of cornea for monitoring alterations of its mechanical rigidity, linear tensiometry was used to quantitate stiffness and Young's modulus (YM) after treatments that increase cornea stiffness (collagen photocross-linking) or decrease stiffness (enzymatic digestion). The endogenous ultraviolet fluorescence of cornea was also measured before and after these treatments. The fluorescence excitation/emission spectral ranges were 280 to 430/390 to 520 nm, respectively. A correlation analysis was carried out to identify fluorescence excitation/emission pairs whose intensity changes correlated with the stiffness. A positive correlation was found between variations in fluorescence intensity of the 415-/485-nm excitation/emission pair and YM of photocross-linked corneas. After treatment of corneas with pepsin, the YM decreased as the fluorescence intensity at 290-/390-nm wavelengths decreased. For weakening of corneas with collagenase, only qualitative changes in the fluorescence spectrum were observed. Changes in the concentration of native or newly created fluorescent molecular species contain information that may be directly or indirectly related to the mechanical structure of the cornea.