gebhart/patrepeval huggingface dataset:
Buffer clustering policy for sequential production lines with deterministic processing times (2016)

A sequential production line is defined as a set of sequential operations within a factory or distribution center whereby entities undergo one or more processes to produce a final product. Sequential production lines may gain efficiencies such as increased throughput or reduced work in progress by utilizing specific configurations while maintaining the chronological order of operations. One problem identified by the authors via a case study is that, some of the configurations, such as work cell or U-shaped production lines that have groups of buffers, often increase the space utilization. Therefore, many facilities do not take advantage of the configuration efficiencies that a work cell or U-shaped production line provide. To solve this problem, the authors introduce the concept of a buffer cluster. The production line implemented with one or more buffer clusters maintains the throughput of the line, identical to that with dedicated buffers, but with the clusters reduces the buffer storage space. The paper derives a time based parametric model that determines the sizing of the buffer cluster, provides a reduced time space for which to search for the buffer cluster sizing, and determines an optimal buffer clustering policy that can be applied to any N-server, N+1-buffer sequential line configuration with deterministic processing time. This solution reduces the buffer storage space utilized while ensuring no overflows or underflows occur in the buffer. Furthermore, the paper demonstrates how the buffer clustering policy serves as an input into a facility layout tool that provides the optimal production line layout.
Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines (2016)

ISCU myopathy is an inherited disease that primarily affects individuals of northern Swedish descent who share a single point mutation in the fourth intron of the ISCU gene. The current study shows correction of specific phenotypes associated with disease following treatment with an antisense oligonucleotide (ASO) targeted to the site of the mutation. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB in patient myotubular cell lines increased to levels observed in control myotubular cell lines. Additionally, we have shown that both patient fibroblast and myotubular cell lines displayed an increase in complex II activity with a concomitant decrease in succinate levels in patient myotubular cell lines after ASO treatment. Mitochondrial and cytosolic aconitase activities increased significantly following ASO treatment in patient myotubes. The current study suggests that ASO treatment may serve as a viable approach to correcting ISCU myopathy in patients.
Frequency-dependent bifurcation point between field-cooled and zero-field-cooled dielectric constant of LiTaO3 nanoparticles embedded in amorphous SiO2 (2004)

Splitting between the field-cooled dielectric constant and the zero-field-cooled dielectric constant was observed for a diluted system of LiTaO3 nanoparticles (diameter ≈30 Å) embedded in amorphous SiO2. At the applied field frequency of 100 kHz, the real part of the field-cooled dielectric constant diverged from that of the zero-field-cooled one at ≈380 °C. The bifurcation point of the history-dependent dielectric constant rose from ≈310 to ≈540 °C upon increasing the field frequency from 10 to 1000 kHz. Bulk LiTaO3 powders showed no splitting in the history-dependent dielectric constant and the maximum at 645 °C in the real part of the dielectric constant, despite the variation of frequency. Both the splitting of the history-dependent dielectric constant and the frequency dependence of the bifurcation point suggest that the LiTaO3 nanoparticles with a single-domain structure were in the superparaelectric state as a consequence of insignificant cooperative interactions among the nanoparticles in the diluted system. The energy barrier of ≈0.9 eV separating two (+p and −p) polarization states corroborated the potential of the LiTaO3 nanoparticle for ultrahigh-density recording media applications.
Huntingtin aggregation monitored by dynamic light scattering (1998)

An initial stage of fibrillogenesis in solutions of glutathione S-transferase-huntingtin (GST-HD) fusion proteins has been studied by using dynamic light scattering. Two GST-HD systems with poly-L-glutamine (polyGln) extensions of different lengths (20 and 51 residues) have been examined. For both systems, kinetics of z-average translation diffusion coefficients (Dapp) and their angular dependence have been obtained. Our data reveal that aggregation does occur in both GST-HD51 and GST-HD20 solutions, but that it is much more pronounced in the former. Thus, our approach provides a powerful tool for the quantitative assay of GST-HD fibrillogenesis in vitro.
Re-architecting Traffic Analysis with Neural Network Interface Cards (2022)

We present an approach to improve the scalability of online machine learning-based network traffic analysis. We first make the case to replace widely-used supervised machine learning models for network traffic analysis with binary neural networks. We then introduce Neural Networks on the NIC (N3IC), a system that compiles binary neural network models into implementations that can be directly integrated in the data plane of SmartNICs. N3IC supports different hardware targets, and it generates data plane descriptions using both micro-C and P4 languages. We implement and evaluate our solution using two use cases related to traffic identification and to anomaly detection. In both cases, N3IC provides up to a 100x lower classification latency, and 1.5-7x higher throughput than state-of-the-art software-based machine learning classification systems. This is achieved by running the entire traffic analysis pipeline within the data plane of the SmartNIC, thereby completely freeing the system's CPU from any related tasks, while forwarding traffic at line rate (40Gbps) on the target NICs. Encouraged by these results we finally present the design and FPGA-based prototype of a hardware primitive that adds binary neural network support to a NIC data plane. Our new primitive requires less than 1-2% of the logic and memory resources of a VirteX7 FPGA. We show through experimental evaluation that extending the NIC data plane enables more challenging use cases that require online traffic analysis to be performed in a few microseconds.
Measurement Method for Adhesion Forces between Polyvinyl Acetal Brushes and Flat Surfaces (2019)

The adhesion force between two materials is a key factor in surface cleaning. In this study, we developed a method for measuring adhesion forces between polyvinyl acetal (PVA) brushes and several test surfaces to understand the brushes' adhesion characteristics. We utilized both the viscoelastic properties of PVA brushes and a high-response load cell to evaluate the adhesion forces of the compressed brushes on a flat surface. The results of the study showed that the adhesion forces increased with increased contact time and amount of compression. Some materials strongly interacted with the PVA brushes. We also observed that the measured adhesion forces were due to the existence of a skin layer on the brush surface. Moreover, we compared the adhesion forces with torques generated from rotating PVA brushes. However, the results did not correlate with the adhesion forces, which suggests that the force in the quasi-static state differs from that in the sliding condition.
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling (2008)

Our study provides a unique database resource for future investigation of the evolutionarily conserved molecular pathways governing the ontogeny and functions of leukocyte subsets, especially DCs.
Nonlinearities and Frequency Stability in NEMS (2017)

NEMS
Physical and electrical analysis of RuxYy alloys for gate electrode applications (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bei Chen, Youseok Suh, Jaehoon Lee, Jason Gurganus, Veena Misra, Cyril Cabral; Physical and electrical analysis of RuxYy alloys for gate electrode applications. Appl. Phys. Lett. 31 January 2005; 86 (5): 053502. https://doi.org/10.1063/1.1857093 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Thermodynamic Analysis on Vapor Phase Epitaxy of GaAs by GaCl3 and AsH3 System (1988)

A thermodynamic analysis of the VPE growth of GaAs using GaCl 3 and AsH 3 is described. It is shown that most of the GaCl 3 converts to GaCl and HCl at about 650°C and that the growth of GaAs is possible by the GaCl 3 and AsH 3 system without using a high temperature zone. The experimental features of the system can be explained well by equilibrium model.
Synthetic studies on quassinoids: total synthesis of (.+-.)-shinjulactone C (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic studies on quassinoids: total synthesis of (.+-.)-shinjulactone CJon L. Collins, Paul A. Grieco, and Raymond S. GrossCite this: J. Org. Chem. 1990, 55, 23, 5816–5818Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jo00310a009https://doi.org/10.1021/jo00310a009research-articleACS PublicationsRequest reuse permissionsArticle Views422Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 1 mu m CMOS/SOI 64 K SRAM with 10 nA standby current (2003)

Summary form only given. The successful design and fabrication of a 64 K SRAM on SIMOX material is discussed. The advantage of the small junction area resulting from mesa isolation is most evident in the very low standby current. An impressively high yield for first-pass material in a research wafer fabrication area was obtained. Aspects of the design relating to the SOI characteristics are discussed and full characterization results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Wordometer -- Estimating the Number of Words Read Using Document Image Retrieval and Mobile Eye Tracking (2013)

We introduce the Wordometer, a novel method to estimate the number of words a user reads using a mobile eye tracker and document image retrieval. We present a reading detection algorithm which works with over 91 % accuracy over 10 test subjects using 10-fold cross validation. We implement two algorithms to estimate the read words using a line break detector. A simple version gives an average error rate of 13,5 % for 9 users over 10 documents. A more sophisticated word count algorithm based on support vector regression with an RBF kernel reaches an average error rate from only 8.2 % (6.5 % if one test subject with abnormal behavior is excluded). The achieved error rates are comparable to pedometers that count our steps in our daily life. Thus, we believe the Wordometer can be used as a step counter for the information we read to make our knowledge life healthier.
Immune response to mutant neo-antigens (2013)

Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging.
The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis (2015)

Neurodegenerative phenotypes reflect complex, time-dependent molecular processes whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus in neurodegeneration has been on individual genes and pathways. In contrast, we assembled a genome-wide regulatory model (henceforth, "interactome"), whose unbiased interrogation revealed 23 candidate causal master regulators of neurodegeneration in an in vitro model of amyotrophic lateral sclerosis (ALS), characterized by a loss of spinal motor neurons (MNs). Of these, eight were confirmed as specific MN death drivers in our model of familial ALS, including NF-κB, which has long been considered a pro-survival factor. Through an extensive array of molecular, pharmacological, and biochemical approaches, we have confirmed that neuronal NF-κB drives the degeneration of MNs in both familial and sporadic models of ALS, thus providing proof of principle that regulatory network analysis is a valuable tool for studying cell-specific mechanisms of neurodegeneration.
Repairing the Capsule to the Transferred Coracoid Preserves External Rotation in the Modified Latarjet Procedure (2016)

Repairing the capsule to the transferred coracoid during the modified Latarjet procedure appears to be beneficial to avoid the limited range of motion in external rotation, but the direct contact of the humeral head and the transferred coracoid might confer a risk of osteoarthritis. Long-term consequences in the clinical setting need to be clarified.
Sequence anomalies in the Cag7 gene of the Helicobacter pylori pathogenicity island (1999)

The severity of Helicobacter pylori-related disease is correlated with a pathogenicity island (the Cag region of about 26 genes) whose presence is associated with the up-regulation of an IL-8 cytokine inflammatory response in gastric epithelial cells. Statistical analysis of the Cag gene sequences calculated from the complete genome of strain 26695 revealed several unusual features. The Cag7 sequence (1,927 aa) has two repeat regions. Repeat region I runs 317 aa in a form of AAA proximal to the protein N terminal; repeat region II extends 907 aa in the middle of the protein sequence consisting of 74 contiguous segments composed from selections among six consensus sequences and includes 58 regularly distributed cysteine residues with consecutive cysteines mostly 12, 18, or 24 aa apart. This "regular" cysteine arrangement may provide a scaffolding of linker elements stabilized by disulfide bridges. When Cag7 homologues from different strains are compared, differences were found almost exclusively in the repeat regions, resulting from deletion and/or insertion of repeating units. These observations suggest that the anomalous repetitive structure of the sequence plays an important role in the conformation of Cag7 gene product and potentially in the function of the pathogenicity island. Other facets of the Cag7 sequence show significant charge clusters, high multiplet count, and extremes of amino acid usage.
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study (2010)

A series of novel openphendioxan analogues were synthesized and tested at α1-adrenoreceptor (AR) subtypes by binding and functional assays. The α1d-AR binding profile was also examined by means of 2D, 3D-QSAR together with docking studies. Multiple regression analysis suggested the relevance of adequate number of heteroatoms in the whole molecule and of passive membrane diffusion to enhance α1d-affinity. Docking simulations against a computational structural model of the biological target further proved this evidence and furnished support for chemiometric analysis, where polar, electrostatic, hydrophobic and shape effects of the ortho substituents in the phenoxy terminal, most likely governing ligand binding, helped the depiction of pharmacophore hypothesis for the examined ligands data set.
Brain responses to auditory and visual stimulus offset: Shared representations of temporal edges (2008)

Edges are crucial for the formation of coherent objects from sequential sensory inputs within a single modality. Moreover, temporally coincident boundaries of perceptual objects across different sensory modalities facilitate crossmodal integration. Here, we used functional magnetic resonance imaging in order to examine the neural basis of temporal edge detection across modalities. Onsets of sensory inputs are not only related to the detection of an edge but also to the processing of novel sensory inputs. Thus, we used transitions from input to rest (offsets) as convenient stimuli for studying the neural underpinnings of visual and acoustic edge detection per se. We found, besides modality-specific patterns, shared visual and auditory offset-related activity in the superior temporal sulcus and insula of the right hemisphere. Our data suggest that right hemispheric regions known to be involved in multisensory processing are crucial for detection of edges in the temporal domain across both visual and auditory modalities. This operation is likely to facilitate cross-modal object feature binding based on temporal coincidence.
Discrimination of Bacillus cereus from Selected Bacillus spp. by Pyrolysis Gas‐Liquid Chromatography (1981)

ABSTRACT Pyrolysis gas‐liquid chromatography (PGLC) and statistical analysis employing stepwise discriminant analysis (SDA), were used to classify five species and varieties in the genus Bacillus. Nine strains were harvested, lyophilized, and pyrolyzed under replicate conditions. The combination of PGLC and SDA enabled classification of these selected varieties and species of Bacillus at 96% accuracy. Stepwise discriminant analysis of the same PGLC data discriminated (100%) B. cereus , a foodborne pathogen, from the remaining selected nonpathogenic bacilli when the two groups were compared. One particular elution peak resulting from the PGLC‐SDA analysis was prominent in both discriminations reported. The PGLC and SDA method offers potential as an accurate, objective procedure for the discrimination of these selected bacilli.
Performance and grain yield stability of maize populations developed using marker-assisted recurrent selection and pedigree selection procedures (2015)

A marker-assisted recurrent selection (MARS) program was undertaken in sub-Saharan Africa to improve grain yield under drought-stress in 10 biparental tropical maize populations. The objectives of the present study were to evaluate the performance of C<sub>1</sub>S<sub>2</sub>-derived hybrids obtained after three MARS cycles (one cycle of recombination (C<sub>1</sub>), followed by two generations of selfing (S<sub>2</sub>), and to study yield stability under both drought-stress (DS) and well-watered (WW) conditions. For each of the 10 populations, we evaluated hybrids developed by crossing 47-74 C<sub>1</sub>S<sub>2</sub> lines advanced through MARS, the best five S<sub>5</sub> lines developed through pedigree selection, and the founder parents with a single-cross tester from a complementary heterotic group. The hybrids and five commercial checks were evaluated in Kenya under 1-3 DS and 3-5 WW conditions with two replications. Combined across DS locations, the top 10 C<sub>1</sub>S<sub>2</sub>-derived hybrids from each of the 10 biparental populations produced 0.5-46.3 and 11.1-55.1 % higher mean grain yields than hybrids developed using pedigree selection and the commercial checks, respectively. Across WW locations, the best 10 hybrids derived from C<sub>1</sub>S<sub>2</sub> of each population produced 3.4-13.3 and 7.9-36.5 % higher grain yields than hybrids derived using conventional pedigree breeding and the commercial checks, respectively. Mean days to anthesis of the best 10 C<sub>1</sub>S<sub>2</sub> hybrids were comparable to those of hybrids developed using the pedigree method, the founder parents and the commercial checks, with a maximum difference of 3.5 days among the different groups. However, plant height was significantly (P < 0.01) different in most pairwise comparisons. Our results showed the superiority of MARS over pedigree selection for improving diverse tropical maize populations as sources of improved lines for stress-prone environments and thus MARS can be effectively integrated into mainstream maize breeding programs.
MULTIPOINT MEASUREMENT OF WALL PRESSURE FLUCTUATIONS IN A SEPARATED AND REATTACHING FLOW OVER A BACKWARD-FACING STEP (2001)

Time-dependent characteristics of wall pressure fluctuations in separated and reattaching flows over a backward-facing step were investigated by means of continuous wavelet transform. Emphasis was placed on the combination of time-localized analyses of wavelet transform and multi-point measurements of pressure fluctuations. Synchronized wavelet maps revealed the evolutionary behavior of pressure fluctuations and gave further insight into the modulated nature of large-scale vortical structures. It was found that there exist two modes of shed vortices: one is the global oscillation and the other is the vortex convection. The two alternating modes are synchronized with the flapping frequency component of pressure fluctuations. Toward the investigation of the direct relationship between the flow field and the relevant spatial mode of the pressure field, a new kind of wavenumber filtering of pressure distribution, termed as a spatial box filtering (SBF), is introduced and examined. The conditional averaged velocity time history reveals that this SBF mode, tuned with the length scale of large-scale vortical structure, suggests its usefulness in capturing the large-scale coherent vortical structure.