gebhart/patrepeval huggingface dataset:
A Highly Luminescent Nitrogen-Doped Nanographene as an Acid- and Metal-Sensitive Fluorophore for Optical Imaging (2021)

Dibenzo[<i>hi</i>,<i>st</i>]ovalene (DBOV) has excellent photophysical properties, including strong fluorescence and high ambient stability. Moreover, the optical blinking properties of DBOV have enabled optical super-resolution single-molecule localization microscopy with an imaging resolution beyond the diffraction limit. Various organic and inorganic fluorescent probes have been developed for super-resolution imaging, but those sensitive to pH and/or metal ions have remained elusive. Here, we report a diaza-derivative of DBOV (N-DBOV), synthesized in eight steps with a total yield of 15%. Nitrogen (N)-bearing zigzag edges were formed through oxidative cyclization of amino groups in the last step. UV-vis and fluorescence spectroscopy of N-DBOV revealed its promising optical properties comparable to those of the parent DBOV, while cyclic voltammetry and density functional theory calculations highlighted its lower orbital energy levels and potential <i>n</i>-type semiconductor character. Notably, in contrast to that of the parent DBOV, the strong luminescence of N-DBOV is dependent on pH and the presence of heavy metal ions, indicating the potential of N-DBOV in sensing applications. N-DBOV also exhibited pH-responsive blinking, which enables pH-sensitive super-resolution imaging. Therefore, N-DBOV appears to be a highly promising candidate for fluorescence sensing in biology and environmental analytics.
A procedure for setting up high-throughput nanolitre crystallization experiments. II. Crystallization results (2003)

An initial tranche of results from day-to-day use of a robotic system for setting up 100 nl-scale vapour-diffusion sitting-drop protein crystallizations has been surveyed. The database of over 50 unrelated samples represents a snapshot of projects currently at the stage of crystallization trials in Oxford research groups and as such encompasses a broad range of proteins. The results indicate that the nanolitre-scale methodology consistently identifies more crystallization conditions than traditional hand-pipetting-style methods; however, in a number of cases successful scale-up is then problematic. Crystals grown in the initial 100 nl-scale drops have in the majority of cases allowed useful characterization of X-ray diffraction, either in-house or at synchrotron beamlines. For a significant number of projects, full X-ray diffraction data sets have been collected to 3 Å resolution or better (either in-house or at the synchrotron) from crystals grown at the 100 nl scale. To date, five structures have been determined by molecular replacement directly from such data and a further three from scale-up of conditions established at the nanolitre scale.
Search for a Light Charged Higgs Boson Decaying to a W Boson and a CP-Odd Higgs Boson in Final States with eμμ or μμμ in Proton-Proton Collisions at s=13  TeV (2019)

A search for a light charged Higgs boson (H^{+}) decaying to a W boson and a CP-odd Higgs boson (A) in final states with eμμ or μμμ is performed using data from pp collisions at sqrt[s]=13 TeV, recorded by the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb^{-1}. In this search, it is assumed that the H^{+} boson is produced in decays of top quarks, and the A boson decays to two oppositely charged muons. The presence of signals for H^{+} boson masses between 100 and 160 GeV and A boson masses between 15 and 75 GeV is investigated. No evidence for the production of the H^{+} boson is found. Upper limits at 95% confidence level are obtained on the combined branching fraction for the decay chain, t→bH^{+}→bW^{+}A→bW^{+}μ^{+}μ^{-}, of 1.9×10^{-6} to 8.6×10^{-6}, depending on the masses of the H^{+} and A bosons. These are the first limits for these decay modes of the H^{+} and A bosons.
Fine Wettability Control Created by a Photochemical Combination Method for Inkjet Printing on Self‐Assembled Monolayers (2012)

Wettability tuning for organic solvents is demonstrated with the "combination method", a reversal of the conventional "cleavage method". Several advantages are inherent to this method: for example, the syntheses are simple, various surface-active groups can be used, and the reaction proceeds with a low-energy light source. The image shows the result after UV irradiation through a patterning mask.
Development of a nafion-free proton transport cellulose membrane for the proton exchange membrane fuel cell (2020)

Proton Exchange Membrane Fuel Cells (PEMFCs) provide a method of producing clean energy through the oxidation and reduction of hydrogen and oxygen gas, with H<sub>2</sub>O emitted as the only by-product. The electrons of the oxidized hydrogen ions travel through a wire to perform work, while the hydrogen ions (protons) migrate to the cathode through a membrane that is impermeable
Nanomechanical non-volatile memory for computing at extreme (2013)

A computing platform that works under extreme conditions (> 250 °C and at radiation > 1 Mrad) can be attractive in a number of important application areas, including automotive, space and avionics. Nanoelectromechanical systems (NEMS) switches have emerged as promising candidates for computing in harsh environment. Designing reliable memory specifically non-volatile memory is a major challenge for these computing systems. In this paper, we propose a novel non-volatile memory (NVM) design for reliable operation in extreme environment using NEMS structure. It exploits a common failure mode in these devices, namely stiction. Unlike traditional charge-based memories, it relies on the mechanical state of a NEMS switch as information carrier. We analyze device and circuit-level design issues to enable robust NVM array implementation with NEMS devices.
Color constancy: generalized diagonal transforms suffice (1994)

This study’s main result is to show that under the conditions imposed by the Maloney–Wandell color constancy algorithm, whereby illuminants are three dimensional and reflectances two dimensional (the 3–2 world), color constancy can be expressed in terms of a simple independent adjustment of the sensor responses (in other words, as a von Kries adaptation type of coefficient rule algorithm) as long as the sensor space is first transformed to a new basis. A consequence of this result is that any color constancy algorithm that makes 3–2 assumptions, such as the Maloney–Wandell subspace algorithm, Forsyth’s MWEXT, and the Funt–Drew lightness algorithm, must effectively calculate a simple von Kries-type scaling of sensor responses, i.e., a diagonal matrix. Our results are strong in the sense that no constraint is placed on the initial spectral sensitivities of the sensors. In addition to purely theoretical arguments, we present results from simulations of von Kries-type color constancy in which the spectra of real illuminants and reflectances along with the human-cone-sensitivity functions are used. The simulations demonstrate that when the cone sensor space is transformed to its new basis in the appropriate manner a diagonal matrix supports nearly optimal color constancy.
Compensation of Laser Frequency Fluctuations and Phase Noise in 16-QAM Coherent Receivers (2013)

Frequency fluctuations caused by mechanical vibrations, power supply noise, and other mechanisms are detrimental to the phase estimator performance in high speed intradyne coherent optical receivers. In this letter, we propose the use of a low-latency parallel digital phase lock loop in combination with common feed-forward carrier phase recovery algorithms in order to compensate both the phase noise and laser frequency fluctuation effects on 16-quadrature amplitude modulation receivers. Numerical results demonstrate the excellent behavior of the proposed two-stage carrier recovery scheme.
Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth (2013)

Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes. Although sialic acids play a vital role in many biologic processes, hypersialylation in particular has been shown to contribute to cancer cell progression and metastasis. Accordingly, selective strategies to interfere with sialic acid synthesis might offer a powerful approach in cancer therapy. In the present study, we assessed the potential of a recently developed fluorinated sialic acid analogue (P-3F(ax)-Neu5Ac) to block the synthesis of sialoglycans in murine melanoma cells and the consequences on cell adhesion, migration, and in vivo growth. The results showed that P-3F(ax)-Neu5Ac readily caused depletion of α2,3-/α2,6-linked sialic acids in B16F10 cells for several days. Long-term inhibition of sialylation for 28 days was feasible without affecting cell viability or proliferation. Moreover, P-3F(ax)-Neu5Ac proved to be a highly potent inhibitor of sialylation even at high concentrations of competing sialyltransferase substrates. P-3F(ax)-Neu5Ac-treated cancer cells exhibited impaired binding to poly-l-lysine, type I collagen, and fibronectin and diminished migratory capacity. Finally, blocking sialylation of B16F10 tumor cells with this novel sialic acid analogue reduced their growth in vivo. These results indicate that P-3F(ax)-Neu5Ac is a powerful glycomimetic capable of inhibiting aberrant sialylation that can potentially be used for anticancer therapy.
Multiple cell lithium-ion battery system electric fault online diagnostics (2015)

This paper introduces an integrated online electrical safety diagnostic algorithm for lithium-ion battery systems, which includes the detection of over charge, over discharge, external short circuit and internal short circuit faults. Experiments were conducted for each fault and the safety criteria, presented by a combination of voltage, current and temperature, were built according to empirical results. Based on the criteria, an integrated electrical fault diagnostic algorithm is proposed. Experimental results show that the proposed algorithm is effective and robust at detecting and distinguishing electric faults for multiple cell battery arrangements online.
Separating components of mixed fluid using a functionally graded material (2023)

A system for separating components of a fluid containing at least a first component and a second component includes a device having an inlet for introducing the fluid into the device, a first outlet for directing the first component of the fluid from the device, and a second outlet for directing the second component of the fluid from the device. A material that has a gradient in properties is located in the device between the inlet and the first and second outlets. The material has a first portion with an affinity for the first fluid component and a second portion with an affinity for the second fluid component. The first portion is positioned with relation to the first outlet such that the first component is directed from said device through the first outlet. The second portion is positioned with relation to the second outlet such that the second component is directed from the device through the second outlet.
The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production (1996)

The lymphoid src kinase pp56(lck) has been shown to be essential for the induction of different T lymphocyte responses, including CD4-mediated enhancement of Ag-induced T cell activation, early T cell differentiation, induction of IL-2 production, and cytotoxicity. It is assumed that pp56(lck) acts on these processes by phosphorylating substrates. However, it has been recently reported that the NH2 regulatory domain is sufficient to mediate CD4 accessory function. In this report we address the contribution of the regulatory and catalytic domains of pp56(lck) to another function of this enzyme independent of CD4: TCR-induced IL-2 production. Two pp56(lck) mutants lacking either the entire catalytic domain or the entire NH2 regulatory domain were generated, and their abilities to trigger transactivation of the TCR-regulated nuclear factor of activated T cells (NF-AT) region of the IL-2 promoter were compared. Only the catalytic, but not the NH2 regulatory, domain of pp56(lck) was able to induce NF-AT region transactivation on its own and to cooperate with other intracellular signals to trigger this response. Moreover, the catalytic domain of pp56(lck) was able to induce IL-2 cytokine production to an extent similar to that of wild-type pp56(lck). We conclude that different domains of the pp56(lck) molecule contribute to regulate distinct biologic functions. In fact, while the NH2 regulatory domain is sufficient to mediate CD4 accessory function, we show here that the catalytic domain of pp56(lck) is sufficient for induction of IL-2 production, mimicking TCR ligation.
Impact of Conditioning on the Outcome of Allografting in Myelofibrosis with Myeloid Metaplasia: Better Survival with Reduced Intensity Approach in Patients ≥50 Years. (2007)

Abstract We analyzed the impact of intensity of conditioning therapy on the outcomes of allogeneic blood or marrow transplantation (BMT) in patients (pts) with myelofibrosis with myeloid metaplasia (MMM). The study included 46 consecutive patients treated at 7 transplant centers between 1998 and 2005. The indications for BMT were intermediate/high risk disease (n=41) or low risk disease with constitutional symptoms (n=5). Donors were matched sibling/family donor (n=25); mismatched family donor, 2; and unrelated, 19. Twenty-three pts received conventional myeloablative (MY) conditioning: Cy/TBI (n=22); Bu/Cy (n=1), and 23 received non-myeloablative (NMA) conditioning [fludarabine (Flu)/PO or IV Bu (n=16); Flu/TBI 200cGy (n=6); others(n=1)]. Median age at BMT of the MY and NMA group was 47 (31–60) and 54 (38–74) years, respectively. NMA group had a higher proportion of pts ≥50 years (74% vs 30%, p=0.003), a longer interval from diagnosis to BMT (p=0.05) and more transplants using blood stem cells (p=0.0002). At a median follow-up of 31 (1–89) months, 8 and 16 patients were alive in MY and NMA groups, respectively. The transplant related outcomes of the two groups are summarized in the table. Serial pre and post BMT bone marrow biopsy results were available in 24 patients. Median days to resolution of fibrosis were 167 and 363 in the MY and NMA groups (p=0.16). In a multivariate analysis, after adjusting for age the survival was better for pts ≥50 years treated with NMA approach (hazard ratio 2.98, 95% CI 1.09–8.12, p=0.03). In conclusion, both MY and NMA approaches have curative potential for pts with MMM. NMA approach is particularly promising in pts ≥50 years. Table: Comparison of BMT related outcomes for MY and NMA conditioning for MMM Outcomes MY Group (95% C.I.) NMA Group (95% C.I.) P value Neutrophil engraftment (days) 21 (13–46) 18 (1–30) 0.01 Cumulative incidence of graft failure (primary and secondary) at 2-years % 30 (16–58) 23 (10–50) 0.51 Median number of hospital days (Day 0 to +100) 41 (26–85) 27 (8–58) 0.0006 Cumulative incidence of acute GvHD grade II–IV (%) 78 (62–98) 18 (7–45) 0.0002 Cumulative incidence of chronic GVHD at 2-years % 94 (79–100) 45 (27–74) 0.0009 Cumulative incidence of TRM at 2-years % 43 (27–70) 27 (14–55) 0.08 Progression free survival at 2-years % 48 (27–66) 64 (40–80) 0.11 Overall survival at 2-years % 57 (34–74) 68 (45–83) 0.08
Advances in AlGaInN laser diode technology for defence and sensing applications (2016)

Laser diodes fabricated from the AlGaInN material system is an emerging technology for defence and security applications. The AlGaInN material system allows for laser diodes to be fabricated over a very wide range of wavelengths from u.v., ~380nm, to the visible ~530nm, by tuning the indium content of the laser GaInN quantum well, giving rise to new and novel applications including displays and imaging systems, atomic clock and quantum information, free-space and underwater telecom and lidar.
Design and evaluation of Feedforward Active ripple filters (2005)

An active ripple filter is an electronic circuit that cancels or suppresses the ripple current and electromagnetic interference generated by the power stage of a power converter, thus reducing the passive filtration requirements. This paper explores the design of feedforward active ripple filters for current ripple cancellation, including the design tradeoffs, advantages, and limitations of different implementation methods. The design and performance of an active filter using a novel Rogowski-coil current sensor is discussed in detail. Experimental results from a prototype converter system using this approach are presented, and quantitative comparisons are made between a hybrid passive/active filter and a purely passive filter. It is demonstrated that substantial improvements in filter mass and converter transient performance are achievable using this active ripple filtering method.
Figure S8 from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells (2023)

&lt;p&gt;Figure S8 provides evidence that ESRP1 loss alone (without Snail expression) is not sufficient to transform epithelial cells in vitro.&lt;/p&gt;
Constant Rate Expressing of Juice from Biological Tissue Enhanced by Pulsed Electric Field (2004)

Abstract Pulsed electric field (PEF) is an innovative technology, which can be successfully combined with solid/liquid expressing of juice from biological materials. The fresh juicy plants contain the juice in closed cells. The application of PEF ensures the electropermeabilization of cellular membranes, which facilitates the expulsion of liquid from the interior of cells. This article describes the influence of PEF on the kinetics of juice extraction from the layer of sugar beet particles expressed at a constant rate. Experimental study was carried out using a laboratory filter-press cell connected to a PEF treatment system. The PEF was applied by two different modes: as a pretreatment operation before pressing and as a treatment during pressing. The application of PEF to nonpressurized cake leads to increase of energy consumption and higher applied voltage. The PEF treatment of excessively pressurized cakes enhances the juice yield; however, the expressing of juice is significantly delayed. The best result is obtained when the sugar beet tissue is treated with PEF at 1.5–5 bars. The influence of PEF parameters on the juice yield was also studied. The intensity of PEF was varied from 0 to 1000 V/cm and the number of pulses was varied between 0 and 1000. It was established that the optimal parameters of PEF after the cake pressurization at 5 bar were in the next range: intensity of PEF E = 500 V/cm and duration of PEF application 0.03–0.05 s.
<title>New similarity measure for color image indexing</title> (2001)

In this paper, we propose a new similarity measure for color images, that is angular distance of cumulative histogram. The measure is compared to previous popular measure that is cumulative L<SUB>1</SUB> distance measure on RGB and HSV color space. We show that our method produces a better result than cumulative L<SUB>1</SUB> distance measure. Moreover, to increase the accuracy, we introduce the weighting method. Weights are applied to the RGB similarity, D<SUB>R</SUB> D<SUB>G</SUB>, D<SUB>B</SUB>, according to a Hue histogram of the query image. The weighting method increase accuracy and perceptually relevant result.
A Multilingual Reading Comprehension System for more than 100 Languages (2020)

Anthony Ferritto, Sara Rosenthal, Mihaela Bornea, Kazi Hasan, Rishav Chakravarti, Salim Roukos, Radu Florian, Avi Sil. Proceedings of the 28th International Conference on Computational Linguistics: System Demonstrations. 2020.
Control of the Type 3 Secretion System in Vibrio harveyi by Quorum Sensing through Repression of ExsA (2010)

The type 3 secretion system (T3SS) genes of Vibrio harveyi are activated at low cell density and repressed at high cell density by quorum sensing (QS). Repression requires LuxR, the master transcriptional regulator of QS-controlled genes. Here, we determine the mechanism underlying the LuxR repression of the T3SS system. Using a fluorescence-based cell sorting approach, we isolated V. harveyi mutants that are unable to express T3SS genes at low cell density and identified two mutations in the V. harveyi exsBA operon. While LuxR directly represses the expression of exsBA, complementation and epistasis analyses reveal that it is the repression of exsA expression, but not exsB expression, that is responsible for the QS-mediated repression of T3SS genes at high cell density. The present work further defines the genes in the V. harveyi QS regulon and elucidates a mechanism demonstrating how multiple regulators can be linked in series to direct the expression of QS target genes specifically at low or high cell density.
Assumption coverage under different failure modes in the time-triggered architecture (2002)

The Time-Triggered Architecture (TTA) is a distributed computer architecture for highly dependable real-time systems. The core building block of the TTA is the communications protocol TTP/C. This protocol has been designed to provide non-faulty nodes with consistent data in the presence of faulty nodes. To achieve this consistency the protocol assumes that a fault is either a reception fault or a consistent send fault of some node. Although the communications protocol of the TTA uses this rather optimistic failure mode assumption, the TTA can isolate and tolerate a broader class of faults. This is possible by making intensive use of the static knowledge present in a TTA distributed computer system. This off-line available knowledge allows to build interconnection networks which transform failure modes of nodes into failure modes the communications protocol can deal with. This paper will discuss three alternative implementations of interconnection networks for the TTA which have been designed to meet different failure mode assumptions.
Polarization consideration in characterizing radio wave propagation in urban microcellular channels (2002)

In this work, the polarization dependence of multipath propagation is investigated for an out of sight side-street in an urban microcellular environment. The investigation is model based. The received power of vertically polarized signals is larger than that of horizontally polarized ones in both narrow and wideband transmission and reception. The fast fading in the vertically co-polarized wave propagation is higher than that of the horizontal polarization. The power delay profiles (PDF) of the two linear polarizations are similar at locations near the junction in the side-street. Considerable difference in the PDF of the two linear polarizations is noticed at larger distance down the side street. The peak value of the power delay profile provides a reasonable estimate of the received signal power in both linear polarizations. At large distance down the side street, the root mean square (RMS) of the vertical polarization PDF is lower than that of the horizontal polarization PDF. The peaks of the horizontal polarization local power delay profiles are more suppressed than their corresponding in the vertical polarization at a large distance.
Correlation of lifetime and recombination zone in green phosphorescent organic light-emitting diodes (2009)

The lifetime of green phosphorescent organic light-emitting diodes was correlated with the charge leakage and recombination zone of the devices. The lifetime of green devices was decreased in the device with an electron leakage out of an emitting layer into a hole transport layer. In particular, the decrease in lifetime at high luminance was significant in the device with an electron leakage into the hole transport layer. In addition, the recombination zone of green devices was shifted from the hole transport layer side to the electron transport layer side during driving.