gebhart/patrepeval huggingface dataset:
Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers (2017)

In advanced systemic mastocytosis (advSM), disease evolution is often triggered by <i>KIT</i> mutations (D816V in >80% of cases) and by additional mutations (eg, in <i>SRSF2</i>, <i>ASXL1</i>, and/or <i>RUNX1</i> [S/A/R<sup>pos</sup> in >60% of cases]). In a recently reported phase 2 study, midostaurin, a multikinase/KIT inhibitor, demonstrated an overall response rate (ORR) of 60% in advSM but biomarkers predictive of response are lacking. We evaluated the impact of molecular markers at baseline and during follow-up in 38 midostaurin-treated advSM patients. The median overall survival (OS) was 30 months (95% confidence interval, 6-54) from start of midostaurin. ORR and OS were significantly different between S/A/R<sup>neg</sup> (n = 12) and S/A/R<sup>pos</sup> (n = 23) patients (ORR: 75% vs 39%, <i>P</i> = .04; OS: <i>P</i> = .01, HR 4.5 [1.3-16.2]). Depending on the relative reduction of the <i>KIT</i> D816V expressed allele burden (EAB) at month 6, patients were classified as <i>KIT</i> responders (≥25%, n = 17) or <i>KIT</i> nonresponders (<25%, n = 11). In univariate analyses at month 6, reduction of <i>KIT</i> D816V EAB ≥25%, tryptase ≥50%, and alkaline phosphatase ≥50% were significantly associated with improved OS. In multivariate analysis, only <i>KIT</i> D816V EAB reduction ≥25% remained an independent on-treatment marker for improved OS (<i>P</i> = .004, HR 6.8 [1.8-25.3]). Serial next-generation sequencing analysis of 28 genes in 16 patients revealed acquisition of additional mutations or increasing variant allele frequency in <i>K</i>/<i>NRAS</i>, <i>RUNX1</i>, <i>IDH2</i>, or <i>NPM1</i> associated with progression in 7 patients. In midostaurin-treated advSM patients, the complexity and dynamics of mutational profiles significantly affect response, progression, and prognosis.
UTILIZAÇÃO DE METILPREDNISOLONA NO TRATAMENTO DO TRAUMA RAQUIMEDULAR (2020)

Introducao: A lesao da medula espinhal traz consequencias devastadoras para o paciente e para o sistema pubico de saude. A principal acao da metilprednisolona (MP) na lesao medular e a inibicao do radical de oxigenio e seu efeito anti-lipidico por oxidacao. Tendo em vista que a utilizacao da MP na abordagem clinica, assim como seu mecanismo de acao, ainda e controversa, notamos a necessidade de realizar esta revisao literaria para esclarecer se e ou nao recomendavel a sua utilizacao no trauma raquimedular. Objetivo : Avaliar se o uso da metilprednisolona e benefico no tratamento do trauma raquimedular. Metodos : os artigos foram encontrados utilizando duas bases de dados, a EBSCOhost e PubMed, sendo utilizados ao todo 18 artigos que respondiam a pergunta “A metilpredinisona e benefica para o tratamento do trauma raquimedular?” Discussao : Um dos principais obstaculos dos estudos que apoiavam a utilizacao da metilpredinisona como terapeutica no trauma raquimedular era a dificuldade em dizer se o beneficio clinico seria vantajoso, ou nao, em relacao as complicacoes decorrentes, seu risco e seu baixo efeito terapeutico comprovado. Portanto, alguns artigos nao apoiam a MP como opcao para terapia, nao sendo mais utilizada na lesao medular aguda em decorrencia de seu baixo grau de recomendacao, grau 1. Conclusoes: O uso de MP atualmente deve ser abolido ate que aparecam estudos com bom grau de evidencia comprovando sua eficacia.
An excited state managing molecular design platform of blue thermally activated delayed fluorescence emitters by π-linker engineering (2020)

A molecular design platform of blue thermally activated delayed fluorescence (TADF) emitters to boost the external quantum efficiency and efficiency roll-off of blue TADF organic light-emitting diodes (OLEDs) was developed.
Intramolecular photoinduced diene-diene cyaloadditions: a selective method for the synthesis of complex eight-membered rings and polyquinanes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular photoinduced diene-diene cyaloadditions: a selective method for the synthesis of complex eight-membered rings and polyquinanesPaul A. Wender and Carlos R. D. CorreiaCite this: J. Am. Chem. Soc. 1987, 109, 8, 2523–2525Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00242a053https://doi.org/10.1021/ja00242a053research-articleACS PublicationsRequest reuse permissionsArticle Views882Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
TGF‐β2 stimulates cranial suture closure through activation of the Erk‐MAPK pathway (2006)

Abstract Cranial sutures are important growth sites of the skull. During suture closure, the dura mater is one of the most important sources of various positive and negative regulatory signals. Previous results indicate that TGF‐β2 from dura mater strongly accelerates suture closure, however, its exact regulatory mechanism is still unclear. In this study, we confirmed that removal of dura mater in calvarial organ culture strongly accelerates sagittal suture closure and that this effect is further enhanced by TGF‐β2 treatment. TGF‐β2 stimulated cell proliferation in the MC3T3‐E1 cell line. Similarly, it stimulated the proliferation of cells in the sutural space in calvarial organ culture. Furthermore, TGF‐β2‐mediated enhanced cell proliferation and suture closure were almost completely inhibited by an Erk‐MAPK blocker, PD98059. These results indicate that TGF‐β2‐induced activation of Erk‐MAPK is an important signaling component that stimulates cell proliferation to enrich osteoprogenitor cells, thereby promoting their differentiation into osteoblasts to achieve a rapid calvarial bone expansion. J. Cell. Biochem. 98: 981–991, 2006. © 2006 Wiley‐Liss, Inc.
Interactions between Subunits of the Human Epithelial Sodium Channel (1997)

The human epithelial sodium channel (hENaC) mediates Na+ transport across the apical membrane of epithelia, and mutations in hENaC result in hypertensive and salt-wasting diseases. In heterologous expression systems, maximal hENaC function requires co-expression of three homologous proteins, the alpha, beta, and gammahENaC subunits, suggesting that hENaC subunits interact to form a multimeric channel complex. Using a co-immunoprecipitation assay, we found that hENaC subunits associated tightly to form homo- and heteromeric complexes and that the association between subunits occurred early in channel biosynthesis. Deletion analysis of gammahENaC revealed that the N terminus was sufficient but not necessary for co-precipitation of alphahENaC, and that both the N terminus and the second transmembrane segment (M2) were required for gamma subunit function. The biochemical studies were supported by functional studies. Co-expression of gamma subunits lacking M2 with full-length hENaC subunits revealed an inhibitory effect on hENaC channel function that appeared to be mediated by the cytoplasmic N terminus of gamma, and was consistent with the assembly of nonfunctional subunits into the channel complex. We conclude that the N terminus of gammahENaC is involved in channel assembly.
An Application of C/GMRES Model Predictive Control to a Diesel Engine Air Path System (2018)

This paper considers an application of a C/GMRES-based model predictive control (MPC) method to a diesel engine air path system. The plant model is derived based on the physical first principle to explicitly take account of plant nonlinearities. Since the plant has unmeasurable states, we employ an extended Kalman filter to estimate them. Then we design a C/GMRES-MPC algorithm and apply it to a real engine. We demonstrate the effectiveness of the present method by showing experimental results using a real vehicle.
Irredundant address bus encoding for low power (2001)

Article Irredundant address bus encoding for low power Share on Authors: Yazdan Aghaghiri University of Southern California, 3740 McClintock Ave, Los Angeles, CA University of Southern California, 3740 McClintock Ave, Los Angeles, CAView Profile , Farzan Fallah Fujitsu Laboratories of America, 595 Lawrence Expressway, Sunnyvale, CA Fujitsu Laboratories of America, 595 Lawrence Expressway, Sunnyvale, CAView Profile , Massoud Pedram University of Southern California, 3740 McClintock Ave, Los Angeles, CA University of Southern California, 3740 McClintock Ave, Los Angeles, CAView Profile Authors Info & Claims ISLPED '01: Proceedings of the 2001 international symposium on Low power electronics and designAugust 2001 Pages 182–187https://doi.org/10.1145/383082.383128Online:06 August 2001Publication History 21citation378DownloadsMetricsTotal Citations21Total Downloads378Last 12 Months10Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
40-Gbaud/s (120-Gbit/s) Octal and 10-Gbaud/s (40-Gbit/s) Hexadecimal Simultaneous Addition and Subtraction Using 8PSK/16PSK and Highly Nonlinear Fiber (2011)

Employing 8PSK and 16PSK modulation formats, non-degenerate four-wave mixing (FWM) in a single highly nonlinear fiber (HNLF), and coherent detection, we experimentally demonstrate 40-Gbaud/s (120-Gbit/s) octal and 10-Gbaud/s (40-Gbit/s) hexadecimal simultaneous addition (A+B) and bidirectional subtraction (A-B, B-A).
Amorphous Refractory Compound Film Material for X-Ray Mask Absorbers (2000)

We proposed that the stress of the side walls of an absorber pattern causes the pattern distortion of an X-ray mask. The surfaces of the pattern side walls have a high compressive stress layer because they are easily oxidized in air after absorber pattern etching. This stress becomes a serious problem in proportion to the high degree of pattern integration. To lower the surface oxide layer stress of the film, we developed a TaGe nitride (TaGeN) absorber. The oxide layer stress of TaGeN films becomes lower with increasing the N 2 content in the sputtering gas, and the stress value of Ta 0.35 Ge 0.20 N 0.45 can be decreased to 1/17 that of TaGe. We fabricated a TaGeN X-ray mask and practically demonstrated that the TaGeN absorber was effective for high image placement accuracy to an X-ray mask having high dense patterns with a 0.1 µm pattern size.
Study of Antiknock Performance Under Various Octane Numbers and Compression Ratios in a DISI Engine (2003)

&lt;div class="htmlview paragraph"&gt;This paper presents a study of antiknock performance under various octane numbers and compression ratios in a direct injection spark ignition (DISI) gasoline engine. The relationship between the octane number and engine performance in the DISI engine-the engine torque and the break specific fuel consumption (BSFC)-was investigated in comparison with a multipoint injection (MPI) engine. Due to the improvement in the charging efficiency and the advance of the ignition timing by cooled aspiration, the engine torque of the DISI engine was improved over that of the MPI engine. It was also found that the octane number requirement (ONR) was reduced.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition, the possibility of engine performance enhancement at high compression ratios was studied. At high compression ratios, the engine torque is reduced due to the heavy knocking when low octane gasoline is used. However, an improvement in the engine torque has been observed with high octane gasoline. An increase in the ONR at a high compression ratio (15.0:1) was observed in both DISI and MPI engines, but the increase in the ONR in the DISI engine was smaller than in the MPI engine. The BSFC got worse under low-speed, high-load conditions at high compression ratios for retardation due to heavy knocking, while the BSFC was improved at low-speed, low-load and at middle speed for better thermal efficiency at high compression ratios.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Finally, the benefits for fuel economy with high compression ratios and high octane gasolines were evaluated using J10-15, ECE-EUDC and LA-4 mode simulations.&lt;/div&gt;
Propagation of a partially coherent focused X-ray beam within a planar X-ray waveguide (2002)

A linear-transmission Fresnel-zone-plate lens is used for coupling a monochromatic X-ray beam of 13.2 keV into a planar X-ray waveguide. The zone plate focuses the beam parallel to the entrance of the waveguide, by which means a flux enhancement of a factor of 54 inside the waveguide is obtained. This substantially enlarges the range of X-ray diffraction experiments that can be performed on samples confined within the waveguide. The coherent properties of the beam, as obtained at a third-generation synchrotron facility, are investigated by comparing the experimental data with numerical calculations in which partial coherence is taken into account by propagation of the mutual intensity function. The conditions for which the X-rays travelling through the waveguide are coherent are discussed.
Two-dimensional multi-frequency imaging of a tumor inclusion in a homogeneous breast phantom using the harmonic motion Doppler imaging method (2017)

Harmonic motion microwave Doppler imaging (HMMDI) is a novel imaging modality for imaging the coupled electrical and mechanical properties of body tissues. In this paper, we used two experimental systems with different receiver configurations to obtain HMMDI images from tissue-mimicking phantoms at multiple vibration frequencies between 15 Hz and 35 Hz. In the first system, we used a spectrum analyzer to obtain the Doppler data in the frequency domain, while in the second one, we used a homodyne receiver that was designed to acquire time-domain data. The developed phantoms mimicked the elastic and dielectric properties of breast fat tissue, and included a [Formula: see text] mm cylindrical inclusion representing the tumor. A focused ultrasound probe was mechanically scanned in two lateral dimensions to obtain two-dimensional HMMDI images of the phantoms. The inclusions were resolved inside the fat phantom using both experimental setups. The image resolution increased with increasing vibration frequency. The designed receiver showed higher sensitivity than the spectrum analyzer measurements. The results also showed that time-domain data acquisition should be used to fully exploit the potential of the HMMDI method.
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated with increased severity, viral load, and mortality during SARS-CoV-2 infections. Patients with severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) and low plasma IFNα and IFNλ levels when compared to non-severe COVID-19 patients. In a mouse model of pulmonary HSV-1 infection, treatment with recombinant IL-3 reduces viral load and mortality. Mechanistically, IL-3 increases innate antiviral immunity by promoting the recruitment of circulating pDCs into the airways by stimulating CXCL12 secretion from pulmonary CD123<sup>+</sup> epithelial cells, both, in mice and in COVID-19 negative patients exhibiting pulmonary diseases. This study identifies IL-3 as a predictive disease marker for SARS-CoV-2 infections and as a potential therapeutic target for pulmunory viral infections.
The synthesis of high magnetization Cu{sub 0.5}Fe{sub 2.5}O{sub 4} (1995)

The ferrite with composition Cu{sub 0.5}Fe{sub 2.5}O{sub 4} was heat treated in reducing atmosphere at different temperatures within the solid solution region as determined by dynamic x-ray characterization. The samples were quenched in oil and air and lattice parameter measurements indicate a lattice expansion at high temperature indicating the reduction of the copper to the +1 state. Magnetization measurements confirm the existence of the Cu{sup +1} ferrite.
Monitoring the Dynamics of Ligand−Receptor Complexes on Model Membranes (2005)

Ligand-induced cross-linking of cell surface receptors is a basic paradigm of signal activation by many transmembrane receptors. After ligand binding, the receptor complexes formed on the membrane are dynamically maintained by two-dimensional protein-protein interactions on the membrane. The biophysical principles governing the dynamics of such interactions have not been understood, mainly because the measurement of lateral interactions on membranes so far has not been experimentally addressed. Here, we describe a generic approach for measuring two-dimensional dissociation rate constants in vitro using a novel high-affinity chelator lipid for reconstituting a ternary cytokine-receptor complex on solid-supported membranes. While monitoring the interaction between the ligand and one of the receptor subunits on the membrane by fluorescence resonance energy transfer, the equilibrium on the surface was perturbed by rapidly tethering a large excess of the unlabeled receptor subunit. Displacement of labeled by unlabeled protein in the ternary complex was detected as a recovery of the donor quenching. Since the dissociation of the ligand-receptor complex in plane of the membrane was the rate-limiting step under these conditions, the two-dimensional rate constant of this process was determined. Strikingly, the two-dimensional dissociation was much slower than ligand dissociation into solution, suggesting that membrane tethering significantly affects the dissociation process. This result highlights the importance of studying ligand-receptor complexes tethered to membranes for understanding the principles governing signal activation by ligand-induced receptor assembling.
5G Xhaul and Service Convergence: Transmission, Switching and Automation Enabling Technologies (2020)

The article provides a review of the Xhaul network in terms of architecture, transmission, switching, and service provisioning automation, with the objective to illustrate the state of the art and indicate the open issues to be addressed. Xhaul is the new transport network segment that covers the first 15-20 km from the access site, replacing today point-to-point fronthaul connections. Due to the high level of capillarity of deployed equipment in this network segment, a simple downsize of the technology used in metro and aggregation networks cannot achieve sufficient cost effectiveness: cost reduction, both in opex and capex, must indeed not compromise the demanding requirements of low latency and high bandwidth. Enabling service convergence is the key feature of Xhaul. The considered network scenario starts from an initial phase, where the Xhaul infrastructure is designed to carry only mobile fronthaul and backhaul traffic, evolving to support enterprises services, as well as vertical services. Such a convergent infrastructure has to support any kind of 5G service, including massive Machine Type Communication (mMTC), extreme Mobile Broad-Band (eMBB), and Ultra-Reliable Low Latency Communication (URLLC). The most important challenges and significant features are illustrated through relevant examples and experiments.
An overview of the data obtained during the validation of an optimized MALDI-TOF MS Biotyper database for the identification of anaerobic bacteria (2018)

This data in brief article presents the data obtained during the validation of the optimized Biotyper Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) database. The validation was performed by the different expertise laboratories, collaborating within the European Network for the Rapid Identification of Anaerobes (ENRIA) project, using 6309 human clinical anaerobic bacterial strains. Different databases were compared with each other; the db 5989 database (V5 database); the V5 database complimented with Main Spectral Profiles (MSPs) of ENRIA strains added to the next update of the database; and the V5 database complimented with the MSPs of all anaerobic clinical isolates collected within the ENRIA project. For a comprehensive discussion of the full dataset, please see the research article that accompanies this data article (Veloo et al., 2018) [1].
The Treatment of Preeclampsia in a Rat Model Employing Digibind® (2009)

Preeclampsia (PE) is a disorder that results in significant fetomaternal morbidity and mortality with yet no definitive pharmacological intervention. It involves the development of de novo hypertension and proteinuria after 20 weeks of pregnancy. All too often, intrauterine growth restriction (IUGR) occurs. Evidence has accrued that implicates the cardiac glycosides (the cardenolides and the bufadienolides) as potentially involved in the pathophysiology of PE. These compounds act by inhibiting Na(+)/K(+) ATPase. Digibind (digoxin immune Fab) antagonizes this action of the cardenolides. It also has cross-reactivity against the bufadienolides, including marinobufagenin. This study investigated the effects of Digibind in a rat model of PE. We induced a syndrome in rats, which includes many of the phenotypic characteristics of human PE. Digibind, in escalating doses, was given on days 10 to 20 of pregnancy. Digibind produced significant lowering of the blood pressure and reduced proteinuria in our rat model of PE. However, it also did not avert IUGR. In view of these findings, in our experimental model of human PE, further studies in the quest for effective treatment of PE need to focus on pharmaceuticals that can remedy the syndrome without compromising the fetus.
Working environment at home and mental health in employees working from home in Japan during COVID-19 pandemic: A cross-sectional study (2023)

Even after adjusting for job stressors and support, working environments at home were associated with employees' mental health. Appropriate measures and education may be needed.