gebhart/patrepeval huggingface dataset:
A Dynamic Location Management Scheme based on individual metrics and coordinates (2004)

Location management in cellular networks have been in focus for the research community for a number of years. The current static method of determining location or paging areas has been shown to be sub- optimal and costly for operators. Therefore, much research has been focussed on dynamic schemes, which show great promise in cost optimisation. However, the research has still been focussed on aggregation of user behaviour and location area determination based on the aggregate. In this paper, we present another solution and argue that per-user behaviour based schemes will perform even better than the aggregate schemes. We present an analytically based proposal, which delegates the responsibility of performing individual updates to the terminals, making the scheme easy to deploy in current cellular systems. In addition, we simulate the relative cost savings obtained compared with the currently used static schemes. The results indicate that our proposed method can cut the cost of location management significantly and free up valuable spectrum for user data.
Enhanced Cellular Support for UAVs with Massive MIMO (2020)

In this chapter, the authors adopt the view of a mobile network operator that, by rolling out its massive multiple input–multiple output (MIMO) based 5G network, aims to offer communication services to both ground users (GUEs) and unmanned aerial vehicles (UAVs) simultaneously, reusing its cellular spectrum and infrastructure. After evaluating the downlink performance of networks with UAV users, they aim to assess whether cellular networks can provide high-speed uplink aerial links for video streaming purposes. An equally important concern is related to the influence that UAV transmissions have on the uplink performance of terrestrial users. The authors evaluate the network performance and capture the propagation environment between ground base stations and both GUEs and UAVs through the latest 3GPP 3D channel model. They also introduce the network topology and channel model. A common feature of the single-user and massive MIMO paradigms is an equal time splitting between downlink and uplink data transmissions.
Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin (2020)

Antimicrobial resistance is a major global threat that calls for new antibiotics. Globomycin and myxovirescin are two natural antibiotics that target the lipoprotein-processing enzyme, LspA, thereby compromising the integrity of the bacterial cell envelope. As part of a project aimed at understanding their mechanism of action and for drug development, we provide high-resolution crystal structures of the enzyme from the human pathogen methicillin-resistant Staphylococcus aureus (MRSA) complexed with globomycin and with myxovirescin. Our results reveal an instance of convergent evolution. The two antibiotics possess different molecular structures. Yet, they appear to inhibit identically as non-cleavable tetrahedral intermediate analogs. Remarkably, the two antibiotics superpose along nineteen contiguous atoms that interact similarly with LspA. This 19-atom motif recapitulates a part of the substrate lipoprotein in its proposed binding mode. Incorporating this motif into a scaffold with suitable pharmacokinetic properties should enable the development of effective antibiotics with built-in resistance hardiness.
Figure S2 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma (2023)

&lt;p&gt;Supplementary Figure 2 | Significantly mutated genes AKT1, PIK3R1, ERBB3, FBXW7, ATM, CHEK2 and MYO3A. Schematics of the identified novel significantly mutated genes (A) AKT1, (B) PIK3R1, (C) ERBB3, (D) FBXW7, (E) ATM, (F) CHEK2 and (G) MYO3A in OCCC. Mutation marks are shown in black (truncating), red (SIFT and PolyPhen damaging prediction), yellow (SIFT or PolyPhen damaging prediction) or white (SIFT and PolyPhen benign prediction). Mutation effects are indicated with a black spot when paired control was available and written in black (previously described mutation) or red (novel mutations).&lt;/p&gt;
Motion estimation from video for high-throughput lens-less 3D millimeter-wave imaging (2021)

Lens-less millimeter-wave (mmWave) imaging of moving objects using a sparse array relies on knowledge of the relative positions between the moving object and the imaging system to enable coherent image reconstruction. However, accurate object position information is rarely available in commercial applications where the moving object, e.g. a conveyor belt or a robot, is controlled independently of the imaging system, or where the imaged objects move autonomously. This poses a significant hurdle for many commercial mmWave imaging applications. We present a video-based motion extraction approach for active mmWave imaging. The object velocity is extracted in real time from motion vectors obtained from a compressed video. This information is combined with readouts from a distance sensor to infer the position of the object at each time instant. Leveraging video-derived motion vectors enables the offloading of computational complexity of 2-D spatial correlations to highly optimized algorithms operating on camera frames. We show experimentally that the image quality of a commercial high-throughput 3-D mmWave imaging system prototype is improved significantly by this approach when the velocity of the target is unknown and time-varying. We furthermore show that image quality is also improved compared to known average motion profiles of the imaged objects. Using a lab setup with known ground truth, we show that the RMS position error is 2.5 mm over a travel length of 0.52 m. This is better than 1/8 of the wavelength at K-band (24 GHz) along the trajectory and thus sufficient to achieve excellent image quality at K-band and longer wavelengths.
Large-scale continuous carbon/glass fiber additive-compression molded composites (2023)

Additive Manufacturing (AM) or 3-D printing has advanced from small-scale desktop printers to large-scale printers. Most of the present large-scale printers utilize feedstock materials in the form of pellets to create composite structures. To create structurally robust composite parts, reinforcements in the form of short fibers (carbon or glass) are often used to impart mechanical properties to the printed parts. However, poor mechanical properties in Z-direction and high porosity of pellets-based printed composites compared to composite manufactured using traditional methods are serious concerns. The authors report a combined approach in the present work, where fiber reinforced composites are printed with a high-throughput continuous fiber deposition method followed by a secondary compression molding process. A specially designed end-effector mounted on a robotic arm is used to print composite preforms. Continuous comingled fibers (Thermofiber 12K CF-PA12, Thermofiber 12K S2-PA12, and Hybrid Thermofiber 12K CF-PA12+PEEK PA6) embedded in the thermoplastic nylon matrix are printed to create composite preform plaques. The printed preforms were further compression molded (CM) using a hydraulic hot-press to create highly consolidated composite parts. The mechanical properties of the continuous fiber composites produced by this combined approach are improved significantly due to the highly aligned continuous fibers and reduced porosity. Flexural strength, flexural modulus, and tensile modulus of AM-CM Thermofiber 12K CF-PA12 UD sample were 615.37 MPa, 75.65 GPa, and 122.23 GPa, respectively.
The convergence of functions to fixedpoints of recursive definitions (1977)

The classical method for constructing the least fixedpoint of a recursive definition is to generate a sequence of functions whose initial element is the totally undefined function and which converges to the desired least fixedpoint. This method, due to Kleene, cannot be generalized to allow the construction of other fixedpoints. In this paper we present an alternate definition of convergence and a new fixedpoint access method of generating sequences of functions for a given recursive definition. The initial function of the sequence can be an arbitrary function, and the sequence will always converge to a fixedpoint that is close to the initial function. This defines a monotonic mapping from the set of partial functions onto the set of all fixedpoints of the given recursive definition.
Hot-spot congestion relief and service guarantees in public-area wireless networks (2002)

No abstract available.
The Concurrent Reading and Writing of Clocks (2016)

As an exercise in synchronization without mutual exclusion, algorithms are developed to implement both a monotonic and a cyclic multiple-word clock that is updated by one process and read by one or more other processes. Capsule Review It is convenient for an operating system to maintain the system clock in shared memory, so it can be read directly by user processes, without a system call. But doing this is tricky if the clock has more than one word of precision, because the system may update the clock while a user process is partway through reading it. This paper presents a simple algorithm for maintaining the clock in shared memory that requires no locking or retries. Theorists will find the algorithm and its correctness proof interesting, while practitioners will find the algorithm useful and easy to implement. Tim Mann v Contents 1 Introduction 1 2 Notation and Theorems 2 3 A Monotonic Clock 3 4 A Cyclic Clock 6 References 7 vi 1 Introduction In an asynchronous multiprocess s...
Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents, and young adults with Barth syndrome (2019)

Barth syndrome (BTHS) is a rare X-linked condition resulting in abnormal mitochondria, cardioskeletal myopathy, and growth delay; however, the effects of BTHS on substrate metabolism regulation and their relationships with tissue function in humans are unknown. We sought to characterize glucose and fat metabolism during rest, submaximal exercise, and postexercise rest in children, adolescents, and young adults with BTHS and unaffected controls and examine their relationships with cardioskeletal energetics and function. Children/adolescents and young adults with BTHS (n = 29) and children/adolescent and young adult control participants (n = 28, total n = 57) underwent an infusion of 6'6'H2 glucose and U-<sup>13</sup> C palmitate and indirect calorimetry during rest, 30-minutes of moderate exercise (50% <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover><mml:mi>V</mml:mi><mml:mo>˙</mml:mo></mml:mover><mml:msub><mml:mi>O</mml:mi><mml:mrow><mml:mn>2</mml:mn><mml:mtext>peak</mml:mtext></mml:mrow></mml:msub></mml:math> ), and recovery. Cardiac function, cardioskeletal mitochondrial energetics, and exercise capacity were examined via echocardiography, <sup>31</sup> P magnetic resonance spectroscopy, and peak exercise testing, respectively. The glucose turnover rate was significantly higher in individuals with BTHS during rest (33.2 ± 9.8 vs 27.2 ± 8.1 μmol/kgFFM/min, P < .01) and exercise (34.7 ± 11.2 vs 29.5 ± 8.8 μmol/kgFFM/min, P < .05) and tended to be higher postexercise (33.7 ± 10.2 vs 28.8 ± 8.0 μmol/kgFFM/min, P < .06) compared to controls. Increases in total fat (-3.9 ± 7.5 vs 10.5 ± 8.4 μmol/kgFFM/min, P < .0001) and plasma fatty acid oxidation rates (0.0 ± 1.8 vs 5.1 ± 3.9 μmol/kgFFM/min, P < .0001) from rest to exercise were severely blunted in BTHS compared to controls. Conclusion: An inability to upregulate fat metabolism during moderate intensity exercise appears to be partially compensated by elevations in glucose metabolism. Derangements in fat and glucose metabolism are characteristic of the pathophysiology of BTHS. A severely blunted ability to upregulate fat metabolism during a modest level of physical activity is a defining pathophysiologic characteristic in children, adolescents, and young adults with BTHS.
The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral Production (2011)

Our results demonstrated the variations in the late restriction activities among closely related TRIM5α orthologues and a subset of human TRIM family proteins, providing further insights into the late restriction activities of TRIM proteins.
Auto-CQT Control and Management Protocol Design (2010)

When wireless communication comes into the era of the 3rd generation, teleservices would become unprecedented rich under the open service access (OSA). Obviously, QoS (quality of service) from customer's view becomes one of the most important factors deciding the deployment strategies of services. CQT that is a typical measurement tool for end-to-end QoS is increasingly attracting the attention of industry. However, the existing automatic testing control mechanisms (ATCM) can not satisfy the complex testing requests. Therefore, this paper introduces a new kind of Auto-CQT Control and Management Interface Protocol with better flexibility and scalability between control system and testing terminals. ACCMP is designed on the basis of the smallest reusable testing units and a testing synchronization mechanism, so it can satisfy the complex combination test requirements of multiple services easily.
Differential T-Cell Recognition of Native and RecombinantMycobacterium tuberculosisGroES (1999)

Mycobacterium tuberculosis GroES was purified from culture filtrate, and its identity was confirmed by immunoblot analysis and N-terminal sequencing. Comparing the immunological recognition of native and recombinant GroES, we found that whereas native GroES elicited a strong proliferative response and release of gamma interferon-gamma by peripheral blood mononuclear cells from healthy tuberculin reactors, the recombinant protein failed to do so. The same difference in immunological recognition was observed in a mouse model of TB infection. Both the native and recombinant preparations were recognized by mice immunized with the recombinant protein. Biochemical characterization including sodium dodecyl sulfate-polyacrylamide gel electrophoresis, two-dimensional electrophoresis, and mass spectrometry analysis of both proteins demonstrated no differences between the native and recombinant forms of GroES except for the eight additional N-terminal amino acids derived from the fusion partner in recombinant GroES. The recombinant fusion protein, still tagged with the maltose binding protein, was recognized by T cells isolated from TB-infected mice if mixed with culture filtrate before affinity purification on an amylose column. The maltose binding protein treated in the same manner as a control preparation was not recognized. Based on the data presented, we suggest that the association of biologically active molecules from culture filtrate with the chaperone GroES may be responsible for the observed T-cell recognition of the native preparation.
Dynamic Analysis of Rolling Tire Using Force Sensor and Transfer Path Identification (2007)

&lt;div class="htmlview paragraph"&gt;The demand for quieter vehicle interiors increases year after year. The dynamic force transmission of rolling tires from the road surface to the spindles is a critical factor in vehicle interior noise. We investigated the dynamic force transmission of a rolling tire as it relates to reducing vehicle interior noise. A test with a tire rolling over a cleat was conducted in order to measure the road forces and the spindle forces. The transfer function of the rolling tire was identified from the experimental results by applying multi dimensional spectral analysis.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition, Computer Aided Engineering (CAE) technology has advanced recently. This enables prediction of spindle forces early in the design stage. One of the most important issues in predicting spindle forces accurately is to clarify the distribution of road forces. This paper also describes the distribution of the dynamic road forces of the rolling tire. The dynamic road forces were directly measured using triaxial force sensors, and the distribution of the road forces at the contact patch was described.&lt;/div&gt;
Contrôle de la Polarisation Lumineuse d’un LASER par injection de porteurs polarisés en spin (2013)

National audience
Microtubules facilitate the stimulated secretion of β-hexosaminidase in lacrimal acinar cells (1998)

Stimulation of lacrimal acini with secretagogues such as carbachol initiates movement and fusion of acinar secretory vesicles with the apical plasma membrane, resulting in release of protein into the nascent tear fluid. Using rabbit lacrimal acini reconstituted in vitro from isolated cells, we have investigated the organization of the apical cytoskeleton and its role in stimulated secretion. Confocal microscopy revealed a microtubule array emanating from the apical region of the acini; the apical region was also enriched in microfilaments and (gamma)-tubulin. Cytokeratin-based intermediate filaments were apically concentrated, and also detected at the cell periphery. Neither confocal microscopy nor biochemical analysis revealed any reorganization of lumenal microfilaments or microtubules which might accompany carbachol-stimulated release of secretory proteins. However, major changes in the acinar microtubule array induced by taxol or nocodazole were correlated with inhibition of carbachol-dependent release of the secreted protein, beta-hexosaminidase. Major changes in lumenal microfilaments induced by jasplakinolide or cytochalasin D did not inhibit the carbachol-dependent release of beta-hexosaminidase; rather, release of beta-hexosaminidase from jasplakinolide- or cytochalasin D-treated carbachol-stimulated acini was markedly increased relative to the release from untreated stimulated acini. Our findings demonstrate that microtubules play a major role in stimulated lacrimal secretion, and suggest a contributory role for microfilaments.
Integrin αXβ2 Is a Leukocyte Receptor for Candida albicans and Is Essential for Protection against Fungal Infections (2012)

The opportunistic fungus Candida albicans is one of the leading causes of infections in immunocompromised patients, and innate immunity provides a principal mechanism for protection from the pathogen. In the present work, the role of integrin α(X)β₂ in the pathogenesis of fungal infection was assessed. Both purified α(X)β₂ and α(X)β₂-expressing human epithelial kidney 293 cells recognized and bound to the fungal hyphae of SC5314 strain of C. albicans but not to the yeast form or to hyphae of a strain deficient in the fungal mannoprotein, Pra1. The binding of the integrin to the fungus was inhibited by β-glucans but not by mannans, implicating a lectin-like activity in recognition but distinct in specificity from that of α(M)β₂. Mice deficient in α(X)β₂ were more prone to systemic infection with the LD₅₀ fungal inoculum decreasing 3-fold in α(X)β₂-deficient mice compared with wild-type mice. After challenging i.v. with 1.5 × 10⁴ cell/g, 60% of control C57BL/6 mice died within 14 d compared with 100% mortality of α(X)β₂-deficient mice within 9 d. Organs taken from α(X)β₂-deficient mice 16 h postinfection revealed a 10-fold increase in fungal invasion into the brain and a 2-fold increase into the liver. These data indicate that α(X)β₂ is important for protection against systemic C. albicans infections and macrophage subsets in the liver, Kupffer cells, and in the brain, microglial cells use α(X)β₂ to control fungal invasion.
L'Année de la régulation n° 6 (2002-2003) (2002)

The introduction aims at first presenting and making sense of various traditions of political economy before introducing the different papers together with the debate. Three main political economy traditions are theoretically distinct in the literature, a distinction which helps understanding the original dimension of the comparative political economy which is discussed in this issue. The paper then presents the articles and the debate by arguing along three lines of questions&#160;: the question of scale and the relations between micro and macro analysis, the political dimension of the political economy, and changes within ideal types models.
Chrysene-based Electron-transporters Realizing Highly Efficient and Stable Phosphorescent OLEDs (2019)

A series of chrysene-based electron-transporters named BnPyPCs (n = 2, 3, 4) end-capped with two 3,5-di(pyridin-n-yl)phenyl moieties with high thermal and electrical stability were successfully dev...
Generation of sidewall defects in InGaN/GaN blue micro-LEDs under forward-current stress (2022)

This work investigates the effect of current stress on InGaN/GaN multiple-quantum-well flip-chip blue micro light-emitting diodes (μ-LEDs) with a mesa size of 30 × 30 μm2 and describes the stress-related mechanisms: defect aggregation and generation, which cause the change in optoelectronic performance of μ-LEDs. A forward-current stress is applied at 75 A/cm2 (0.7 mA) for 200 h. The device performance degrades with increasing stress time except until 25 h. During the initial 25 h of aging, the light output power and the external quantum efficiency (EQE) increase due to the improved crystal quality caused by aggregation of point defects in the active region, which are supported by the ideality factor and the S-parameter. The high-resolution emission-microscope images reveal that the generation of point defects at mesa sidewalls rather than the active region is crucial in performance degradation. We highlight, in particular, that the aging test generates sidewall point defects even though the sidewalls were properly passivated by a thick SiO2 layer. The mechanisms of defect aggregation and generation due to aging are consistently described by the ideality factor, the S-parameter, and the EQE.
Evading the host immune response: how foot-and-mouth disease virus has become an effective pathogen (2008)

Foot-and-mouth disease virus (FMDV) causes an economically devastating disease of cloven-hoofed animals. In this review, we discuss the mechanisms FMDV has evolved to counteract the host innate and adaptive immune responses and the role of viral proteins in this process. The viral leader proteinase, L pro, limits the host innate response by inhibiting the induction of interferon beta (IFN beta) mRNA and blocking host cell translation. A second viral proteinase, 3C pro, may affect host cell transcription because it cleaves histone H3. Viral protein 2B in conjunction with 2C or their precursor 2BC inhibits protein trafficking through the endoplasmic reticulum and Golgi apparatus. A decrease in surface expression of major histocompatibility class I molecules during FMDV infection suggests that 2B, 2C and/or 2BC may be involved in delaying the initiation of the host adaptive immune response and also adversely affect the secretion of induced signaling molecules. FMDV also causes a transient lymphopenia in swine, but the mechanism involved is not understood nor have any viral protein(s) been implicated. Furthermore, the interaction of FMDV with various cells in the immune system including lymphocytes and dendritic cells and the possible role of apoptosis and autophagy in these interactions are discussed.