gebhart/patrepeval huggingface dataset:
Atorvastatin Improves the Impaired Baroreflex Sensitivity via Anti-Oxidant Effect in the Rostral Ventrolateral Medulla of SHRSP (2009)

We have demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in brainstem, increases sympathetic nerve activity (SNA) and that oral administration of atorvastatin inhibited SNA via anti-oxidant effect in the RVLM of stroke-prone spontaneously hypertensive rats (SHRSPs). The impairment of baroreflex sensitivity (BRS) is known as the predictive factor of mortality in the hypertension and BRS is impaired in SHRSP. The aim of the present study was to determine whether oral administration of atorvastatin improved the impaired BRS via anti-oxidant effect in the RVLM in SHRSP. Atorvastatin (20 mg/kg/day) or vehicle was orally administered for 28 days in SHRSPs. Systolic blood pressure (SBP), heart rate, and 24-h urinary norepinephrine excretion as an indicator of SNA were comparable between atorvastatin- and control-SHRSP. Thiobarbituric acid-reactive substance (TBARS) levels as a marker of oxidative stress was significantly lower in atorvastatin-SHRSP than in control-SHRSP. Baroreflex sensitivity measured by the spontaneous sequence method was significantly higher in atorvastatin-SHRSP than in control-SHRSP. These results suggest that atorvastatin improves the impaired BRS in SHRSP via its anti-oxidant effect in the RVLM of SHRSP.
Data-Retention-Voltage-Based Analysis of Systematic Variations in SRAM SEU Hardness: A Possible Solution to Synergistic Effects of TID (2019)

Single-event upset (SEU) hardness varies across dies, wafers, and lots—even just after fabrication and further across time. Mechanisms of postfabrication variations include total ionizing dose (TID) effects, which are caused by long-term radiation exposure. This synergistic effect of TID on SEU hardness is a particular concern in integrated circuits used in space and nuclear radiation environments. This article shows that an electrical parameter called the data-retention voltage is useful in dealing with such TID effects on the SEU hardness of static random access memories (SRAMs), which are known to be particularly radiation-sensitive. Experiments showed that TID-induced variations in SRAM SEU hardness, i.e., variations in SEU cross sections, were predicted by measuring the data-retention voltage. In addition, these variations were canceled out by adjusting the power supply voltage according to its interesting relationship to the data-retention voltage. Results suggest that it might be possible in flight to predict and cancel out SEU hardness variations caused by TID and other synergistic effects.
Three-Dimensional Navier–Stokes Computation of Turbomachinery Flows Using an Explicit Numerical Procedure and a Coupled k–ε Turbulence Model (1992)

An explicit, three-dimensional, coupled Navier–Stokes/k–ε technique has been developed and successfully applied to complex internal flow calculations. Several features of the procedure, which enable convergent and accurate calculation of high Reynolds number two-dimensional cascade flows, have been extended to three dimensions, including a low Reynolds number compressible form of the k–ε turbulence model, local time-step specification based on hyperbolic and parabolic stability requirements, and eigenvalue and local velocity scaling of artificial dissipation operators. A flux evaluation procedure, which eliminates the finite difference metric singularity at leading and trailing edges on H- and C-grids, is presented. The code is used to predict the pressure distribution, primary velocity, and secondary flows in an incompressible, turbulent curved duct flow for which CFD validation quality data are available. Also, a subsonic compressor rotor passage, for which detailed laser, rotating hot-wire, and five-hole pressure probe measurements have been made is computed. Detailed comparisons between predicted and measured core flow and near-wall velocity profiles, wake profiles, and spanwise mixing effects downstream of the rotor passage are presented for this case. It is found that the technique provides accurate and convergent engineering simulation of these complex turbulent flows.
Primary Leiomyosarcoma of the Testis (1989)

We report a case of primary leiomyosarcoma of the testis, which was believed to originate from normal testicular structures containing smooth muscle cells, such as blood vessels and contractile cells of the seminiferous tubules. No evidence of tumor spread was found. Treatment consisted of orchiectomy with high ligation of the spermatic cord. The patient received no adjuvant therapy. There was no evidence of tumor after 2 years. The literature is reviewed and the therapeutic approach is discussed.
DeepWiERL: Bringing Deep Reinforcement Learning to the Internet of Self-Adaptive Things (2020)

Recent work has demonstrated that cutting-edge advances in deep reinforcement learning (DRL) may be leveraged to empower wireless devices with the much-needed ability to "sense" current spectrum and network conditions and "react" in real time by either exploiting known optimal actions or exploring new actions. Yet, understanding whether real-time DRL can be at all applied in the resource-challenged embedded IoT domain, as well as designing IoT-tailored DRL systems and architectures, still remains mostly uncharted territory. This paper bridges the existing gap between the extensive theoretical research on wireless DRL and its system-level applications by presenting Deep Wireless Embedded Reinforcement Learning (DeepWiERL), a general-purpose, hybrid software/hardware DRL framework specifically tailored for embedded IoT wireless devices. DeepWiERL provides abstractions, circuits, software structures and drivers to support the training and real-time execution of state-of-the-art DRL algorithms on the device's hardware. Moreover, DeepWiERL includes a novel supervised DRL model selection and bootstrap (S-DMSB) technique that leverages transfer learning and high-level synthesis (HLS) circuit design to orchestrate a neural network architecture that satisfies hardware and application throughput constraints and speeds up the DRL algorithm convergence. Experimental evaluation on a fully-custom software-defined radio testbed (i) proves for the first time the feasibility of real-time DRL-based algorithms on a real-world wireless platform with multiple channel conditions; (ii) shows that DeepWiERL supports 16x data rate and consumes 14x less energy than a software-based implementation, and (iii) indicates that S-DMSB may improve the DRL convergence time by 6x and increase the obtained reward by 45% if prior channel knowledge is available.
Automatic tracking of arbitrarily shaped implanted markers in kilovoltage projection images: A feasibility study (2014)

The proposed method can track arbitrary marker shapes in kV images using templates generated from a breath-hold CT acquired at simulation. The studies indicate its feasibility for tracking tumor motion during rotational treatment. Investigation of the causes of misregistration suggests that its rate of incidence can be reduced with higher frequency of image acquisition, templates made from smaller CT slice spacing, and correction of changes in intermarker relative positions when they occur.
Synthesis of 3-O-β-N-Acetylglucosaminyl Cyclic Tetrasaccharide through a Lysozyme-catalyzed Transfer Reaction (2003)

Egg white lysozyme was found to catalyze the transfer of N-acetylglucosamine to cyclo[-->6)-alpha-D-Glcp-(1-->3)-alpha-D-Glcp-(1-->6)-alpha-D-Glcp-(1-->3)-alpha-D-Glcp-(1-->] (CTS). Structural analysis showed that the transfer product was 3-O-beta-N-acetylglucosaminyl CTS, cyclo[-->6)-alpha-D-Glcp-(1-->3)-alpha-D-Glcp-(1-->6)-[beta-GlcNAc-(1-->3)]-alpha-D-Glcp-(1-->3)-alpha-D-Glcp-(1-->]. This branched saccharide is anticipated to be a model compound of the sugar chains of glycoproteins.
Imaging Current Distributions and Temperature Profiles in GaN HEMTs using Nitrogen Vacancy Centers in Nanodiamonds (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Foy, K. R. Bagnall, M. E. Trusheim, A. Lauri, E. N. Wang, and D. Englund, "Imaging Current Distributions and Temperature Profiles in GaN HEMTs using Nitrogen Vacancy Centers in Nanodiamonds," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper ATu3J.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Wirkung von Formoterol auf die mukoziliare Clearance bei Patienten mit COPD (2005)

Einer der charakteristischen Befunde bei COPD-Patienten ist eine schwere Störung der mukoziliaren Clearance. Dabei ist die Frage offen, ob die Clearance Störung für die Entstehung des Krankheitsbildes mitverantwortlich oder lediglich ihre Folge ist. Der Einfluss von Medikamenten auf die mukoziliare Clearance kann prinzipiell für den Krankheitsverlauf bedeutsam sein, sei es durch Stimulation der gestörten Clearance oder durch deren Hemmung. In dieser Studie wurde die Wirkung von Formoterol (Foradil P®) auf die Clearance untersucht.
ChemInform Abstract: Some Synthetic Approaches to Ropinirole (SKPF 101468‐A): A Potent Dopamine Receptor Agonist. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Superconducting microstrip line band-pass filter for mobile applications (2002)

Two types of 2 GHz band superconducting microstrip line band-pass filters were developed: a 5-pole filter with good spurious and sharp skirt characteristics, and an electrically tunable filter. The 5-pole filter with center frequency of 1.95 GHz, insertion loss of 0.1 dB or less, 3 dB bandwidth of 25 MHz, transmission zeros on both sides of desirable band, and good spurious characteristic between 1 and 9 GHz was obtained. Also the tunable filter with a measured unloaded Q factor of 2100 and a frequency shift of approximately 15 MHz was obtained.
Dislocation Analysis in Metal-Oxide Materials and Devices by Electron Channeling Contrast Imaging (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Investigation of the Electrode-Electrolyte Interphase in Ester-Based Electrolytes in NCM523/Graphite Cells (2022)

The use of methyl acetate (MA) and methyl propionate (MP) as co-solvents in carbonate/LiPF 6 electrolytes have been investigated in LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523)/graphite cells to improve electrochemical performance at low temperature (−20 °C). Consistent with previous investigations, improved low temperature performance was observed with all electrolyte formulations containing esters. Detailed ex situ surface analysis of the surface films generated with the ester-based electrolytes containing electrolyte additives reveal significant changes to the SEI on graphite upon cycling at moderately elevated temperature (45 °C). In the presence of vinylene carbonate (VC) lithium plating is observed upon cycling at low temperature (−20 °C) which leads to a thicker solid electrolyte interface (SEI) upon cycling at 45 °C. Incorporation of fluoroethylene carbonate (FEC) as an electrolyte additive results in the generation of a thin SEI and alters the structure of the surface film on the NCM523 cathode resulting in stable cycling over a wide temperature range.
Impact of chip power dissipation on thermodynamic performance (2005)

Chip power consumption is quickly becoming an important issue because of increased electricity costs and thermal management limitations. Existing techniques assess the impact of chip power dissipation by evaluating maximum junction temperature and total power consumption, but only limited information is available about what power profile may be optimal within allowable limits. This paper explores these issues by analyzing chip packages from an exergy perspective. The framework required for such an analysis is developed, and example cases are presented to illustrate application of the technique. Different design choices are explored in the context of traditional thermodynamic efficiencies as well as a recently proposed exergy-based figure-of-merit.
Quantification of Wellbore Leakage Risk Using Non-destructive Borehole Logging Techniques (2014)

Well integrity is important at all potential CCS locations and may play a crucial role establishing leakage risk in areas where there is a high density of existing wells that could be impacted by the storage operations including depleted petroleum fields where EOR or CCS will occur. To address a need for risk quantification methods that can be directly applied to individual wells using borehole logging tools a study was conducted using data from five wells in Wyoming. The objectives of the study were: Objective 1: Develop methods to establish the baseline flow parameters (porosity and permeability or mobility) from individual measurements of the material properties and defects in a well. Objective 2: Develop a correlation between field flow-property data and cement logs that can be used to establish the flow-properties of well materials and well features using cement mapping tools. Objective 3: Establish a method that uses the flow-property model (Objective 2) to analyze the statistical uncertainties associated with individual well leakage that can provide basis for uncertainty in risk calculations. The project objectives were met through the logging of five wells in Carbon and Natrona County Wyoming to collect data that was used to estimate individual and average well flow properties and model the results using ultrasonic data collected during the logging. Three of the five wells provided data on point and average flow properties for well annuli. Data from the other two wells were used to create models of cement permeability and test whether information collected in one well could be used to characterize another well. The results of the in-situ point measurements were confirmed by the lab measurements sidewall cores collected near the same depths Objective 1 was met using the data collected through logging, testing, and sampling. The methods were developed that can establish baseline flow parameters of wells by both point and average test methods. The methods to estimate the flow properties modeling of point pressure tests, modeling of vertical interference tests, and laboratory measurement of cased-hole sidewall cores The wells were in sufficiently good shape to allow the development of the characterization methods while still having enough defects to study differences in results as they relate to well integrity. Samples and tests analyzed from three of five wells studied in showed the cements were largely intact and had not degraded from exposure native brines. Log results taken in conjunction with the core measurements indicate that interfaces and/or problems with cement placement due to eccentering provide preferential flow paths for fluids, which can increase the effective permeability of the barrier several orders of magnitude above the permeability of intact cement. The results of the maps created using logging tools indicating that the cement condition and bond are generally good identify a need for more research to understand how logs can be used to predicteffective well permeabilities such as those measured by the VITs in this study.
Wireless Backhaul Node Placement for Small Cell Networks (2014)

Small cells have been proposed as a vehicle for wireless networks to keep up with surging demand. Small cells come with a significant challenge of providing backhaul to transport data to(from) a gateway node in the core network. Fiber based backhaul offers the high rates needed to meet this requirement, but is costly and time-consuming to deploy, when not readily available. Wireless backhaul is an attractive option for small cells as it provides a less expensive and easy-to-deploy alternative to fiber. However, there are multitude of bands and features (e.g. LOS/NLOS, spatial multiplexing etc.) associated with wireless backhaul that need to be used intelligently for small cells. Candidate bands include: sub-6 GHz band that is useful in non-line-of-sight (NLOS) scenarios, microwave band (6-42 GHz) that is useful in point-to-point line-of-sight (LOS) scenarios, and millimeter wave bands (e.g. 60, 70 and 80 GHz) that are recently being commercially used in LOS scenarios. In many deployment topologies, it is advantageous to use aggregator nodes, located at the roof tops of tall buildings near small cells. These nodes can provide high data rate to multiple small cells in NLOS paths, sustain the same data rate to gateway nodes using LOS paths and take advantage of all available bands. This work performs the joint cost optimal aggregator node placement, power allocation, channel scheduling and routing to optimize the wireless backhaul network. We formulate mixed integer nonlinear programs (MINLP) to capture the different interference and multiplexing patterns at sub-6 GHz and microwave band. We solve the MINLP through linear relaxation and branch-and-bound algorithm and apply our algorithm in an example wireless backhaul network of downtown Manhattan.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy (2020)

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.
Table S1 from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors (2023)

&lt;p&gt;Cross-species plasma stability of STA-12-8666 as a function of time&lt;/p&gt;
Enhancing the understanding of the glycerol to lactic acid reaction mechanism over AuPt/TiO2 under alkaline conditions (2020)

The oxidation of glycerol under alkaline conditions in the presence of a heterogeneous catalyst can be tailored to the formation of lactic acid, an important commodity chemical. Despite recent advances in this area, the mechanism for its formation is still a subject of contention. In this study, we use a model 1 wt. % AuPt/TiO<sub>2</sub> catalyst to probe this mechanism by conducting a series of isotopic labeling experiments with 1,3-<sup>13</sup>C glycerol. Optimization of the reaction conditions was first conducted to ensure high selectivity to lactic acid in the isotopic labeling experiments. Selectivity to lactic acid increased with temperature and concentration of NaOH, but increasing the O<sub>2</sub> pressure appeared to influence only the rate of reaction. Using 1,3-<sup>13</sup>C glycerol, we demonstrate that conversion of pyruvaldehyde to lactic acid proceeds via a base-promoted 1,2-hydride shift. There was no evidence to suggest that this occurs via a 2,1-methide shift under the conditions used in this study.
Altered Mental Status and a Retro-auricular Mass (2006)

A 29-year-old woman was found lying unconscious in the shower. There was a two-day history of headache and dizziness. In the emergency room, she was initially stuporous (Glasgow Coma Scale 10/15), afebrile, bradycardic and hypertensive. She exhibited roving, conjugate eye movements, left facial paresis (including frontalis), left ptosis, diffuse hypotonia, extensor plantar responses bilaterally and a 1.5 cm warm, fluctuant mass with surrounding erythema behind the left ear (Figure 1). Otoscopy revealed a bulge in the posterior wall of the left external auditory canal.
A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity (2014)

Our results, showing the inability of p17 to activate CXCR1_300_142, a receptor found to be expressed on immune cells of patients with a low progression of HIV disease, point to a crucial role of p17 in AIDS pathogenesis. Our findings herein call for an exploration of the therapeutic potential of blocking the p17/CXCR1 axis in HIV infection.
Scalable application layer multicast (2002)

We describe a new scalable application-layer multicast protocol, specifically designed for low-bandwidth data streaming applications with large receiver sets.Our scheme is based upon a hierarchical clustering of the application-layer multicast peers and can support a number of different data delivery trees with desirable properties.We present extensive simulations of both our protocol and the Narada application-layer multicast protocol over Internet-like topologies.Our results show that for groups of size 32 or more, our protocol has lower link stress (by about 25%), improved or similar end-to-end latencies and similar failure recovery properties.More importantly, it is able to achieve these results by using orders of magnitude lower control traffic.Finally, we present results from our wide-area testbed in which we experimented with 32-100 member groups distributed over 8 different sites.In our experiments, average group members established and maintained low-latency paths and incurred a maximum packet loss rate of less than 1% as members randomly joined and left the multicast group.The average control overhead during our experiments was less than 1 Kbps for groups of size 100.
Chord-based image reconstruction from clinical projection data (2008)

Chord-based algorithms can eliminate cone-beam artifacts in images reconstructed from a clinical computed tomography (CT) scanner. The feasibility of using chord-based reconstruction algorithms was evaluated with three clinical CT projection data sets. The first projection data set was acquired using a clinical 64-channel CT scanner (Philips Brilliance 64) that consisted of an axial scan from a quality assurance phantom. Images were reconstructed using (1) a full-scan FDK algorithm, (2) a short-scan FDK algorithm, and (3) the chord-based backprojection filtration algorithm (BPF) using full-scan data. The BPF algorithm was capable of reproducing the morphology of the phantom quite well, but exhibited significantly less noise than the two FDK reconstructions as well as the reconstruction obtained from the clinical scanner. The second and third data sets were obtained from scans of a head phantom and a patient's thorax. For both of these data sets, the BPF reconstructions were comparable to the short-scan FDK reconstructions in terms of image quality, although sharper features were indistinct in the BPF reconstructions. This research demonstrates the feasibility of chord-based algorithms for reconstructing images from clinical CT projection data sets and provides a framework for implementing and testing algorithmic innovations.