gebhart/patrepeval huggingface dataset:
Physical Cue based Depth-Sensing by Color Coding with Deaberration Network (2019)

Color-coded aperture (CCA) methods can physically measure the depth of a scene given by physical cues from a single-shot image of a monocular camera. However, they are vulnerable to actual lens aberrations in real scenes because they assume an ideal lens for simplifying algorithms. In this paper, we propose physical cue-based deep learning for CCA photography. To address actual lens aberrations, we developed a deep deaberration network (DDN) that is additionally equipped with a self-attention mechanism of position and color channels to efficiently learn the lens aberration. Furthermore, a new Bayes L1 loss function based on Bayesian deep learning enables to handle the uncertainty of depth estimation more accurately. Quantitative and qualitative comparisons demonstrate that our method is superior to conventional methods including real outdoor scenes. Furthermore, compared to a long-baseline stereo camera, the proposed method provides an error-free depth map at close range, as there is no blind spot between the left and right cameras.
An Update on Emerging Memory: Progress to 2Xnm (2012)

This paper will give an update on the status of emerging memory (EM) and potential markets. The more popular EM technologies will be reviewed, including PCM, RRAM, and STRAM. The biggest challenges for each technology will be highlighted.
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αIIbβ3 (2008)

UV-C irradiation has been shown to be effective for pathogen reduction in platelet concentrates, but preliminary work indicated that UV-C irradiation of platelets can induce platelet aggregation. In this study, the mechanism underlying this phenomenon was investigated. Irradiation of platelets with UV-C light (1500 J/m(2)) caused platelet aggregation, which was dependent on integrin alphaIIbbeta3 activation (GPIIb/IIIa). This activation occurred despite treatment with several signal transduction inhibitors known to block platelet activation. UV-C also induced activation of recombinant alphaIIbbeta3 in Chinese hamster ovary (CHO) cells, an environment in which physiologic agonists fail to activate. Activation of alphaIIbbeta3 requires talin binding to the beta3 tail, yet alphaIIbbeta3-Delta724 (lacking the talin binding site) was activated by UV-C irradiation, excluding a requirement for talin binding. The UV-C effect appears to be general in that beta(1) and beta(2) integrins are also activated by UV-C. To explain these findings, we investigated the possibility of UV-C-induced photolysis of disulfide bonds, in analogy with the activating effect of reducing agents on integrins. Indeed, UV-C induced a marked increase in free thiol groups in platelet surface proteins including alphaIIbbeta3. Thus, UV-C appears to activate alphaIIbbeta3 not by affecting intracellular signal transduction, but by reduction of disulfide bonds regulating integrin conformation.
The importance of the 5′‐region in regulating the stability of sdh mRNA in Bacillus subtilis (1990)

The decay of the polycistronic Bacillus subtilis sdh mRNA was analysed using probes specific for each of the component cistrons, sdhC, sdhA and sdhB. In exponentially growing cells, the entire sdh mRNA seems to decay with an 'all or nothing' mechanism and with a uniform half-life of 2-3 min for all cistrons. In stationary-phase cells, the half-life of the 5'-part had dropped to about 0.6 min whereas that of the 3'-part was about 1.2 min. Decay of sdh mRNA was also measured in exponentially growing cells containing a 'down-mutation' in the ribosomal binding site preceding sdhC which decreases the expression of sdhC by about 90%. The mutation has a moderate effect on expression of the downstream cistron sdhA. In this mutant, the half-life of the 5'-part of sdh mRNA was about 0.5 min (i.e. the same as in stationary phase wild-type cells) and the half-life of the 3'-part about 1.3 min. Also, analysis of the decay of an sdh-cat fusion transcript revealed that the sdh (5') part decayed more rapidly than the cat part and this difference was more pronounced in stationary-phase cells compared to exponentially growing cells. The results of these experiments demonstrate the importance of the 5'-segment of sdh mRNA in controlling the stability of the transcript under different growth conditions.
Genome-Wide Microarray Analyses Identify the Protein C Receptor as a Novel Calcineurin/Nuclear Factor of Activated T Cells–Dependent Gene in Vascular Smooth Muscle Cell Phenotypic Modulation (2011)

We hereby report PROCR as a novel, NFAT-dependent gene that may be implicated in vascular restenosis and consequent inward remodeling.
Wi-Fi Multi-Link Operation: An Experimental Study of Latency and Throughput (2023)

In this article, we investigate the real-world capability of the multi-link operation (MLO) framework—one of the key MAC-layer features included in the IEEE 802.11be amendment—by using a large dataset containing 5 GHz spectrum occupancy measurements on multiple channels. Our results show that when both available links are often busy, as is the case in ultra-dense and crowded scenarios, MLO attains the highest throughput gains over single-link operation (SLO) since it is able to leverage multiple intermittent transmission opportunities. As for latency, if the two links exhibit statistically the same level of occupancy, MLO can outperform SLO by one order of magnitude. In contrast, in asymmetrically occupied links, MLO can sometimes be detrimental and even increase latency. We study this somewhat unexpected phenomenon, and find its origins to be packets suboptimally mapped to either link before carrying out the backoff, with the latter likely to be interrupted on the busier link. We cross validate our study with real-time traffic generated by a cloud gaming application and quantify MLO’s benefits for latency-sensitive applications.
Capturing 3D stretchable surfaces from single images in closed form (2009)

We present a closed form solution to the problem of recovering the 3D shape of a nonrigid potentially stretchable surface from 3D-to-2D correspondences. In other words, we can reconstruct a surface from a single image without a priori knowledge of its deformations in that image. State of the art solutions to nonrigid 3D shape recovery rely on the fact that distances between neighboring surface points must be preserved and are therefore limited to inelastic surfaces. Here, we show that replacing the inextensibility constraints by shading ones removes this limitation while still allowing 3D reconstruction in closed-form. We demonstrate our method and compare it to an earlier one using both synthetic and real data.
Monte Carlo-fluid hybrid model of the accumulation of dust particles at sheath edges in radio-frequency discharges (1991)

Particulate contamination (dust) has been observed to accumulate near the sheath-plasma boundary in both radio-frequency (rf) and direct-current (dc) discharges. We have developed and applied a hybrid Monte Carlo-fluid simulation of electron, ion, and charged dust transport in rf discharges to investigate the dynamics of particulate contamination. The processes governing the transport of charged dust in the model are drift of partially shielded particles in the electric field, collisions with the fill gases, and viscous ion drag arising from Coulomb interactions of particles with ions drifting and diffusing in the plasma. We find that negatively charged dust particles accumulate near the sheath-plasma boundary, and that transport of the particles is dominated by ion drag.
Pharmacogenomic polygenic risk score for clopidogrel responsiveness among Caribbean Hispanics: A candidate gene approach (2021)

This multicenter clinical study was aimed at conducting a targeted pharmacogenomic association analysis of residual on-clopidogrel platelet reactivity in 474 Caribbean Hispanic patients. Platelet reactivity was measured using the VerifyNow P2Y12 assay and clopidogrel resistance was defined as P2Y12 reaction units (PRUs) greater than or equal to 208. Genotyping was performed using the whole-genome Infinium MEGA BeadChip array. An ancestry-adjusted, weighted polygenic risk score (wPGxRS) was developed to account for the effect of multiple variants on PRU and compared between clopidogrel responders and nonresponders. The mean PRU across the study cohort was 173.8 ± 68.5 and 33.5% of patients were defined as clopidogrel resistant. Multivariate linear regression showed that 19% of PRU variability was attributed to nine independent predictors, with CYP2C19*2 (rs4244285) accounting for ~ 7% of observed PRU variation (p < 0.001). PON1 rs662, ABCB1/MDR1 rs2032582, PEAR1 rs12041331 carrier status, and the interaction between African ancestry and rs12041331 carriers also predicted PRU among the participants (p ≤ 0.05). A clear gene-dose effect was detected between PRU and CYP2C19*2 genotype, consistent with previous studies in European patient populations, as well as rs12777823. Importantly, a significant positive correlation was detected between our novel wPGxRS (4 variants) and PRU among the Hispanic patient population (r<sub>p</sub> = 0.35, p < 0.001). Moreover, the wPGxRS discriminated between nonresponders and responders (p = 0.003), indicating that this multigene-based score is a useful predictor of clopidogrel resistance among Caribbean Hispanics. Taken together, these results help close the gap of knowledge on clopidogrel pharmacogenomics and its potential clinical implementation in this under-represented population.
Cell-Type-Specific Enhancement of Amyloid-β Deposition in a Novel Presenilin-1 Mutation (P117L) (1998)

The presenilin-1 (PS1) gene mutation (Pro117Leu), recently identified in a Polish family is characterized by the earliest reported onset (from 24-31 years) of Alzheimer disease (AD) and a very short duration of disease (4-6 years). The neuropathology of 2 subjects with this PS1 mutation (ages at death: 35 and 37 years) was compared to four Down syndrome (DS) patients (mean age at death: 62 years) and 4 sporadic AD patients (mean age at death: 79 years with a mean duration of disease of 18 years). The Polish familial AD (FAD) patients showed a marked increase in the amyloid burden of 2 6-fold in most areas of the brain. The entorhinal cortex was an exception where the amyloid burden was similar in each category of patient. Some brain regions of the Polish FAD patients showed a massive increase of amyloid, such as the molecular layer of the cerebellum where a 7- and 25-fold increase was noted, compared with DS and sporadic AD patients respectively. The cerebellar vessel amyloid burden was also greatly increased in the FAD patients, reflecting a vascular compartment specific increase of amyloid beta deposition. The presence of this PS1 mutation has an even greater effect on both vascular and parenchymal amyloid deposition, than the overexpression of the amyloid beta precursor protein present in DS patients, suggesting that PS mutations can be a critical factor determining amyloid deposition.
Schema Design of Illegally Parked Bicycles LOD (2016)

Illegally parked bicycles are a social problem in Japan and other countries. Illegally parked bicycles obstruct vehicles, cause road accidents, encourage thefts, and disfigure streets. In order to solve the challenge posed by illegally parked bicycles, we realized that it is necessary to collect and republish the data as reusable format. Therefore, we collected the number of illegally parked bicycles, location information, time, and factors. Then, we integrated and republished these data as Linked Open Data (LOD) on the Web. In this paper, we described a schema design of illegally parked bicycles LOD and a methodology of designing LOD schema. Furthermore, we collected data from SNS and website of municipality, and built the LOD of 21,898 triples.
An α-Carboline-containing Host Material for High-efficiency Blue and Green Phosphorescent OLEDs (2011)

Abstract An α-carboline derivative, 9,9′-m-phenylenedi-α-carboline (mCaP) was designed and synthesized as a host material for phosphorescent OLEDs. By using a combination with phosphorescent emitters such as FIrpic and Ir(ppy)3, we have successfully developed high-performance OLEDs with a power efficiency (ηp,100) at 100 cd m−2 of 37 lm W−1 for blue, and 94 lm W−1 for green, respectively.
Linear and Nonlinear Analysis of the Carotid Sinus Baroreflex Dynamic Characteristics (2019)

The arterial baroreflex system is an important negative feedback system that controls arterial pressure (AP) within a normal range during daily activities. We have analyzed this system in anesthetized animals. Several issues need to be considered: the presence of physiological and measurement noises that interfere with the system identification, the closed-loop nature of the arterial baroreflex system, the existence of parallel feedback systems that may modify the system responses, and the presence of nonlinear responses. We opened the negative feedback loop by surgically isolating the carotid sinus baroreceptor regions from the systemic circulation. We eliminated the effects from parallel feedback systems by sectioning the aortic depressor and vagal nerves. We used a white noise approach to estimate the system characteristics under contamination of physiological and measurement noises. The arterial baroreflex system may be divided into the neural and peripheral arc subsystems. The neural arc represents the relationship between pressure inputs and efferent sympathetic nerve activity (SNA), which may be regarded as a controller subsystem. The peripheral arc represents the relationship between SNA and AP, which may be regarded as a plant subsystem. The neural arc reveals derivative characteristics whereas the peripheral arc reveals low-pass characteristics. Numerical simulations based on the analytical results indicate that the neural arc compensates for the slow peripheral arc to optimize the arterial baroreflex system in achieving both stability and quickness. Impairment of arterial baroreflex function is associated with cardiovascular diseases, and artificial activation of the arterial baroreflex system could be a device-based treatment for cardiovascular diseases associated with sympathetic hyperactivity. To improve the efficacy of such device-based therapy, we may need to understand the interactions between stimulated and non-stimulated baroreflex systems. Although static sigmoidal nonlinearity of the arterial baroreflex with threshold and saturation phenomena is well documented, dynamic nonlinearities are less understood. Further efforts are warranted to fully understand arterial baroreflex function and to apply the knowledge to the medical field.
Highly Reactive 2,5-Disubstituted Styrene-Based Monomer Polymerized via Stable Free Radical Polymerization:  Effect of Substitution and Liquid Crystallinity on Polymerization (2001)

The stable free radical polymerization (SFRP) of a liquid crystalline monomer 2,5-bis[(4-butylbenzoyl)oxy]styrene, BBOS, was investigated. BBOS is a substituted styrenic monomer, which polymerizes an order of magnitude faster than styrene under identical bulk polymerization conditions. A comparative study of the polymerization behavior in bulk and solution for BBOS and a model compound was undertaken to elucidate the effect of both electron-withdrawing substituents and liquid crystallinity of the monomer on the polymerization kinetics. Molecular simulation was used to identify a non-LC model monomer, 2,5-diacetoxystyrene (DAS). DAS was polymerized by stable free radical polymerization both in bulk and in solution. In all cases narrow molecular weight distribution (<1.4) was obtained. In bulk, DAS polymerized significantly slower than BBOS, whereas in a dilute solution, the rate of polymerization was quite similar. In-situ X-ray studies carried out during polymerization of BBOS in the neat monomer indicate the presence of a nematic phase which could lead to localized ordering of the monomers during polymerization. In comparison, DAS was found to be more reactive than styrene, because of the electronic effect of the acetoxy groups. However, p-acetoxystyrene (PAS) was found to have almost the same observed rate of polymerization as DAS, indicating that steric factors also play an important role in O-substituted compounds.
Experimental study of XPM in 10-Gb/s NRZ pre-compensated transmission systems (2007)

We experimentally assess the nonlinear tolerance of 10-Gb/s NRZ in a pre-compensated dispersion map. It is observed that even for relatively wide 100-GHz channel-spacing, XPM further reduces the nonlinear tolerance in contrast to periodically-compensated maps.
Electrical characterization of plastic encapsulations using an alternative gate leakage test method (2008)

The supply current of plastic encapsulated microelectronic devices in the presence of a high potential source can increase abnormally due to parasitic gate leakage. According to reliability qualification standards, stress during a parasitic gate leakage test is applied by a corona discharge at a thin tungsten needle placed a few centimeters above the devices under test. The gate leakage sensitivity factor obtained from this test lacks any physical basis and is therefore not believed to be useful. Here we show that this sensitivity factor can be replaced by a physical model for charge transport through the encapsulation material. The model is used to explain why devices encapsulated by a molding compound with a low volume resistivity of 6 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> Ohm-cm, at high temperature, 150degC, are more prone to fail the test on an increased current, compared to devices encapsulated by a compound having a high resistivity of 4 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> Ohmtimescm at the same temperature. Furthermore, we discuss an alternative test setup where the potential difference between two parallel electrodes sandwiching the devices is used as the source of stress. It is suggested in literature that this setup yields identical results as the current setup. However, using both setups on the same product did not result in an equal outcome, which indicates that both tests do not trigger the same failure mechanism to the same extent.
Cerebral White Matter Lesions, Retinopathy, and Incident Clinical Stroke (2002)

In this cohort, middle-aged persons with cerebral WMLs detected on MRI were more likely to have retinal microvascular abnormalities and to have an increased risk of clinical stroke than people without WMLs. The risk of stroke was higher when retinopathy was simultaneously present in persons with WMLs.
Supplementary Table S4 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2023)

&lt;p&gt;Supplementary Table S4. Compounds affecting ciliary dynamics.&lt;/p&gt;
Interaction between n-type amorphous hydrogenated silicon films and metal electrodes (1982)

The interactions of Al and NiCr electrodes with hydrogenated n-type amorphous silicon films have been investigated in a temperature range of 100–350 °C. It was found that pits were produced in the a-Si films at temperatures above 170 °C in the case of Al electrodes, while they were not observed in the case of NiCr electrodes even if heat-treated at a temperature of 350 °C. From the Auger electron spectroscopy measurements, it was shown that a marked interdiffusion of Al and Si occurs. The sheet resistance of the a-Si films began to increase at temperatures above 170 °C. The contact resistivity between the a-Si films and Al electrodes could not be determined in the case of a-Si films with usual low conductivity. For the specimens with high conductivity [σ∼1(Ω cm)−1], the value of about 1×10−3Ω cm2 was obtained.
Evaluation of Bromocriptine in the Treatment of Acute Severe Peripartum Cardiomyopathy (2010)

In this trial, the addition of bromocriptine to standard heart failure therapy appeared to improve left ventricular ejection fraction and a composite clinical outcome in women with acute severe PPCM, although the number of patients studied was small and the results cannot be considered definitive. Larger-scale multicenter and blinded studies are in progress to test this strategy more robustly.
Excessive GH expression in bGH transgenic mice adversely alters bone architecture and quality (2013)

L4 cortical BMD was significantly reduced in bGH mice compared to WT mice. Mechanical testing of femora confirmed that bGH femora have decreased intrinsic mechanical properties compared to WT mice. Osteoclast activity is increased in bGH tibia compared to controls.
ChemInform Abstract: A Convenient, Highly Stereoselective, Metal‐Free Synthesis of Chiral Amines. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immunosuppression and modulation in liver transplantation (2004)

Recent advances in immunosuppressive drug regimens have changed the outcome after liver transplantation significantly in the last two decades. However, chronic rejection and long-term graft survival remains a major problem. Side effects like drug-induced nephrotoxicity, hypertension, osteoporosis, hyperlipidaemia and neuropathy of some immunosuppressive agents play an essential role in long-term allograft and patient survival. This review outlines the current treatment of short- and long-term immunosuppression in liver transplanted patients, it summarizes the treatment of acute and chronic rejection, describes the complications and side effects of immunosuppressive therapy and points out the current use of immunosuppressive therapy in living-related liver transplantation.
Complementing single-cell RNA-seq using bulk transcriptional profiles (2017)

While high-throughput single cell technologies enable in depth examination of specific cell subsets, these experiments lack the context of these subsets in other cell types and diseases. We compared novel dendritic and monocyte signatures from single cell RNAseq with bulk transcriptome of immune cells to show that the gene signatures for the novel cell subsets are also up-regulated in functionally related but non-parental cell populations. We extended utility of these signatures by demonstrating their consistent down-regulation in cancers, up-regulation in autoimmune diseases, and signature-specific effects in infections. We encourage other researchers to similarly complement their experiments and analyses using existing, publicly available datasets.
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine (2022)

Children with brain tumors harbor very low levels of ctDNA in blood, CSF, and urine, with CSF having the most DNA detectable. Molecular profiling is feasible in a small subset of high-grade tumors. The level of clonal aberrations per genome is low in most of the tumors, posing a challenge for detection using whole-genome or even targeted sequencing methods. Substantial challenges therefore remain to genetically characterize pediatric brain tumors from liquid biopsies.