gebhart/patrepeval huggingface dataset:
Attenuation compensated spectral slopes during the kinetics of Rouleaux formation for porcine whole blood in couette flow at 10-70 MHz (2005)

The characterization of red blood cell (RBC) aggregation using ultrasound is a promising technique allowing in vivo and in situ assessment of its level in the human body. It is known that pathological levels of RBC aggregation are correlated with diseases involving hemorheological disorders. Important efforts have thus been targeted towards theoretical and empirical studies on ultrasonic absolute RBC backscatter. In this study, we present ultrasonic absolute backscatter values (BSC), and spectral slope (SS) dependencies as a function of temporal shear rate variations. Porcine anti-coagulated blood at 40% hematocrit was placed in a modified Couette flow system at 37/spl deg/C. Backscattered RF data were digitized and analyzed, using three wideband focused transducers of central frequencies 10, 35 and 55 MHz. BSC and SS were calculated for each transducer to provide kinetic profiles during aggregation and disaggregation of RBC. The reference medium used for absolute BSC values was a 6% hematocrit suspension of RBC in Ringer solution (no aggregation). Frequency dependent beam variations were taken in account using a diffraction correction factor. Different results on BSC and SS sensitivity for "small aggregates" and "large aggregates" are described as a function of frequency. The size of the aggregates was varied by modifying the flow shear rate. According to these experimental results, it is shown that spectral slopes between 10-70 MHz could be of clinical relevance for in vivo detection of red blood cell aggregation. This index may be of interest to display parametric images of RBC aggregates.
Comprehensive and efficient workload compression (2020)

This work studies the problem of constructing a representative workload from a given input analytical query workload where the former serves as an approximation with guarantees of the latter. We discuss our work in the context of workload analysis and monitoring. As an example, evolving system usage patterns in a database system can cause load imbalance and performance regressions which can be controlled by monitoring system usage patterns, i.e., a representative workload, over time. To construct such a workload in a principled manner, we formalize the notions of workload representativity and coverage. These metrics capture the intuition that the distribution of features in a compressed workload should match a target distribution, increasing representativity, and include common queries as well as outliers, increasing coverage. We show that solving this problem optimally is computationally hard and present a novel greedy algorithm that provides approximation guarantees. We compare our techniques to established algorithms in this problem space such as sampling and clustering, and demonstrate advantages and key trade-offs.
Adaptive Multilevel Nonuniform Grid Algorithm for the Accelerated Analysis of Composite Metallic–Dielectric Radomes (2021)

An adaptive multilevel nonuniform grid (MLNG) algorithm is developed for the accelerated computation of fields radiated through composite metallic–dielectric radomes as well as antenna-radome interactions. The MLNG approach is applied to the mixed potential formulation of the coupled surface and volume electric field integral equations. The radome is decomposed into a hierarchy of subdomains (SDs) by an adaptive algorithm that closely follows the radome geometry, allowing significant savings in memory and CPU time. In the MLNG algorithm, only local generalized impedance matrices of the finest level SDs are evaluated. Far-zone potentials and fields are indirectly evaluated through a multilevel aggregation involving phase-and amplitude-compensated interpolation on nonuniform grids (NGs), requiring considerably fewer calculations as compared with the classical method of moments (MoM). The MLNG algorithm is incorporated in a preconditioned iterative solver. Accuracy as well as memory consumption and computation times of the algorithm are studied on realistic examples. The radome effect on the antenna input impedance and electric current density distribution is demonstrated. The method is validated by comparison with a commercial MoM software and shown to exhibit a computational complexity (CC) of O(NlogN), N being the number of unknowns.
Supplementary Figure 1 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor (2023)

&lt;p&gt;Supplementary Figure 1 - PDF file 1233K, Supplemental Figure 1: Representative array comparative genomic hybridization (aCGH) results of genomic copy number near-normal GIST (left column, n=5) and genomic copy number abnormal GIST (right column, n=5) (Agilent 180K catalogue assay)&lt;/p&gt;
The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex. (1994)

We investigated the role of the complementarity determining region 1 (CDR1) of T cell receptor (TCR) beta chain both in antigen/major histocompatibility complex I (MHC I) and in superantigen (SAg)/MHC II complex recognition. Residues 26 to 31 of the V beta 10 domain of a TCR derived from an H-2Kd-restricted cytotoxic clone were individually changed to alanine, using site-directed mutagenesis, and the mutated TCR beta chains were transfected along with the wild-type TCR alpha chain into a TCR alpha-beta-T hydridoma. These mutations affected antigen/H-2Kd complex recognition, although to a different extent, as estimated by interleukin 2 production. Certain mutations also affected differently the recognition of two Staphylococcal toxins, exfoliative toxin and Staphylococcal enterotoxin C2, presented by HLA-DR1. Whereas mutation of residues D30 or T31 affect the recognition of both toxins, residues T26, L27, and H29 are critical for the recognition of only one of the SAgs. These observations demonstrate the participation of the CDR1 region in the recognition of peptide/MHC class I as well as SAg/MHC II complexes.
Development of micro-optical projection tomography for 3D analysis of single cells (2004)

The Micro-Optical Projection Tomographic Microscope (&#956;OPTM) is an instrument that is being developed for three-dimensional (3D) imaging of cells and subcellular components. The target application for the &#956;OPTM is the early detection of lung cancer by revealing the complex 3D information about chromatin redistribution in the nucleus. The µOPTM employs a scanning objective lens (100x, N.A.=1.25) to create an extended depth-of-field image, similar to a shadowgram or projection, that we call a pseudo-projection. A large number of pseudo-projections (90+) are acquired, from which a tomographically reconstructed 3D image is computed using a filtered backprojection algorithm. The prototype &#956;OPTM uses a single objective lens, so the object (cell) must be rotated for each new pseudo-projection. A custom microtube stage minimizes the lateral and axial motion of the sample tube during scanning and rotation so that registration between successive pseudo-projections is maintained. Image processing methods are used to correct any remaining registration errors. The media inside and outside the tube are refractive index-matched to each other and to the tube (&#916;navg < 0.02). The index-matched materials are pressed between two flat parallel windows, providing a nearly distortion-free image. Custom phantoms using microspheres have been constructed and images of these 3D test targets acquired. The minimum resolvable feature size is better than 3 microns. The first 3D image of a cell using &#956;OPTM is also shown.
The Concept of Performance-Oriented Yaw-Control Systems: Vehicle Model and Analysis (2002)

&lt;div class="htmlview paragraph"&gt;In the last few years, extended research has been performed by car manufacturers in order to improve the handling, safety and comfort of ground vehicles. As a results, modern cars are equipped with many electronic automatic control devices. Among them the yaw-control system is probably the most critical and challenging. Road vehicles are complex non-linear dynamic systems, and the control of some of their motions needs the development of adequate full-vehicle models. In this paper a complete dynamic model of a road vehicle is derived and discussed, which can be suitably used to develop the new concept of “performance-oriented” yaw-control system.&lt;/div&gt;
On using a priori channel statistics for cyclic prefix optimization in OFDM (2011)

Current communication schemes rely on instantaneous adaptation, which increases the system complexity and is memoryless. We propose a scheme for adapting system parameters based on a priori knowledge of the channel statistics to reduce feedback requirements. As a vital parameter in OFDM system, cyclic prefix (CP) length depends mainly on two channel characteristics: the channel gains and the root mean square (RMS) delay spread. Previous research assume given RMS delay spread and utilize power delay profile (PDP) for CP optimization. Since PDP indeed acts as a priori statistics of channel gains, we compare its effectiveness against a feedback scheme based on the instantaneous channel. We further simplify CP optimization by employing the prior statistics of the RMS delay spread. We derive a closed form approximation scheme for computation simplicity assuming RMS delay spread follows a lognormal distribution. We consider ergodic capacity and measure the capacity loss w.r.t. an instantaneous scheme. The observed 1% - 4% capacity loss through simulation validates our proposed scheme. We also present an online method to learn the prior statistics of RMS delay spread from feedback whenever available.
Novomodo, een nieuwe manier om certificaten te valideren (2003)

De Novomodo PKl-oplossing weet door elegant gebruik van hashberekenÃ­ngen de hoeveelheid data en het aantal RSA-berekenÃ­ngen te beperken dat nodÃ­g is voor het valideren van een certificaat. Dit is nuttig bij gebruik van PKI in gelimiteerde omgevingen waar bandbreedte, rekencapaciteit en geheugen beperkt zijn. Ook bÃ­edt Novomodo voordelen op het gebied van effÃ­ciÃ«ntie en kosten, wat met name bij omvangrijke PKI's van belang Ã­s. Daarnaast biedt het mogelijkheden voor nieuwe toepassingen.
Rapid estimation of power consumption for hybrid FPGAs (2008)

A hybrid FPGA consists of island-style fine-grained units and domain-specific coarse-grained units. This paper describes an approach to estimate the power consumption of a set of hybrid FPGA architectures. The dynamic power consumption of the fine-grained units is obtained using standard FPGA tools, and the coarse-grained units using standard ASIC tools. Based on this approach, the dynamic power consumption of different hybrid FPGA architectures can be studied and we report on results over a set of floating point benchmark circuits.
Polyimide Foam Development and Characterization for Lightweight Integrated Structures (2004)

I. Abstract N experimental study was undertaken to investigate the commercial process development of polyimide foams for applications such as the thermal protection system for a cryogenic tank integrated structure. The objective of cryogenic foam development is to develop polyimide foams caused from the reaction of monomeric solutions with increased use temperature. Using the ASTM D – 3574 specification, different foam densities ranging from 0.5 to 8.0 PCF were tested for flatwise tensile and compression strength at room, elevated (350°F) and subzero temperatures (65°F). Room temperature shear strength and modulus was determined using ASTM C-273. Results showed that the tensile strength increases linearly with density up to the 5.0 PCF. However, the 5.0 and 8.0 PCF density tensile strengths are virtually identical. The subzero (-65°F) temperature testing had little effect on the strength. Mechanical testing results showed that higher density TEEK foams would be more suitable for integrated structural applications that require foams with higher structural strength. A
ROMK inwardly rectifying ATP-sensitive K+ channel. I. Expression in rat distal nephron segments (1995)

The inwardly rectifying, ATP-sensitive K+ channel (ROMK) was localized by in situ hybridization in the rat kidney. Tissue in situ hybridization revealed that transcripts encoding the ROMK channel were expressed predominantly in cortical and outer medullary nephron segments. The localization of ROMK mRNA to specific nephron segments was assessed by hybridization of isolated nephron segments with an ROMK-specific probe (single segment in situ hybridization). ROMK mRNA was present in cortical and medullary thick ascending limb, distal tubule, and cortical and outer medullary collecting ducts, but not in proximal tubule. A weak hybridization was observed with inner medullary collecting ducts. To confirm these results, serial cryosections were alternatively stained by hybridization histochemistry for ROMK mRNA or by immunocytochemistry using antibodies specific for S1, S2, or S3 proximal tubular segments. Tubular cells that displayed immunoreactivity with the proximal tubular segment-specific antibodies showed little, if any, ROMK message. In addition, using an in situ hybridization and immunocytochemistry double-labeling technique, ROMK transcripts and vitamin D-dependent calcium-binding protein were shown to colocalize to the distal tubule (distal convoluted tubule and connecting tubule). The overall nephron localization of ROMK mRNA shown in these studies is consistent with the possibility that this novel channel may represent the low-conductance ATP-sensitive K+ channel that has been identified in apical membranes of thick limb and collecting duct segments and is believed to participate in K+ secretion.
Localization of Type 8 17β-hydroxysteroid Dehydrogenase mRNA in Mouse Tissues as Studied by In Situ Hybridization (2005)

The enzyme type 8 17beta-hydroxysteroid dehydrogenase (17beta-HSD) selectively catalyzes the conversion of estradiol (E2) to estrone (E1). To obtain detailed information on the sites of action of type 8 17beta-HSD, we have studied the cellular localization of type 8 17beta-HSD mRNA in mouse tissues using in situ hybridization. In the ovary, hybridization signal was detected in granulosa cells of growing follicles and luteal cells. In the uterus, type 8 17beta-HSD mRNA was found in the epithelial (luminal and glandular) and stromal cells. In the female mammary gland, the enzyme mRNA was seen in ductal epithelial cells and stromal cells. In the testis, hybridization signal was observed in the seminiferous tubule. In the prostate, type 8 17beta-HSD was detected in the epithelial cells of the acini and stromal cells. In the clitoral and preputial glands, labeling was detected in the epithelial cells of acini and small ducts. The three lobes of the pituitary gland were labeled. In the adrenal gland, hybridization signal was observed in the three zones of the cortex, the medulla being unlabeled. In the kidney, the enzyme mRNA was found to be expressed in the epithelial cells of proximal convoluted tubules. In the liver, all the hepatocytes exhibited a positive signal. In the lung, type 8 17beta-HSD mRNA was detected in bronchial epithelial cells and walls of pulmonary arteries. The present data suggest that type 8 17beta-HSD can exert its action to downregulate E2 levels in a large variety of tissues.
Detection of dilute sperm samples using photoacoustic flowmetry (2008)

Detection of sperm cells in dilute samples may have application in forensic testing and diagnosis of male reproductive health. Due to the optically dense subcellular structures in sperm cells, irradiation by nanosecond laser pulses induces a photoacoustic response detectable using a custom flow cytometer. We determined the detection threshold of bull sperm using various concentrations, from 200 to 1,000,000 sperm cells per milliliter. Using a tunable laser system set to 450nm with a 5 ns pulse duration and 11-12 mJ/pulse, we obtained a detection threshold of 3 sperm cells. The flow rate was 4 ml/minute through the flow chamber. The acoustic sensor was a 100 &mu;m PVDF film attached to the glass flow chamber. The acoustic signal was preamplified and sent to an oscilloscope. The threshold signal indicated a signal to noise ratio of approximately 6 to 1. Improved system design may decrease the threshold to single sperm cells.
Network controlled cell selection for the high speed downlink packet access in UMTS (2004)

An expanded effort is underway to support the evolution of the UMTS standard to meet the rapidly developing needs associated with wireless Internet applications. The support of high speed downlink packet access (HSDPA) is provided by means of a new, shared channel called high speed downlink shared channel (HS-DSCH) which is enabled by a number of performance enhancing technologies such as adaptive modulation and coding (AMC), hybrid ARQ (HARQ), fat-pipe scheduling, fast cell selection (FCS) and multiple input multiple output (MIMO) antenna techniques. In this paper, the advantage of FCS is investigated. To avoid the difficulty in HARQ transmission-state synchronization, FCS is allowed only among the cells (sectors) belonging to the same base station. Two FCS approaches are compared in this paper. The user controlled cell selection (UCCS) selects the serving cell based only on the channel quality seen by the user. While a new-network controlled cell selection (NCCS) approach jointly considers channel quality and network loading. It is shown that FCS significantly improves the HSDPA performance at low mobility. Among the FCS schemes, NCCS is superior to UCCS when the load among the cells in the active set is unbalanced.
Velocity Measurements of a Jet Injected into a Supersonic Crossflow (1997)

This paper presents a quantitative, experimental study of a single, sonic, underexpanded, transverse, round jet injected into a Mach 1.6 crosse ow. This investigation is applicable to studies of supersonic combustors, thrust vector control of rocket nozzles, the cooling of nozzle walls, and jet reaction force prediction. Schlieren/shadowgraph photography and two-component, frequency preshifted laser Doppler velocimetry are used to visualize the e ow and to measure three mean velocity components, e ve of the six kinematic Reynolds stresses, and turbulent kinetic energy at over 4000 locations throughout the e owe eld. The study focuses on the transverse, midline plane and on two crosse ow planes. These measurements are used to study the size and orientation of the recirculation regions upstream and downstream of the jet; the structure and strength of the bow shock, barrel shock, and Mach disk; the structure, strength, and development of the kidney-shaped, counter-rotating vortex pair; the growth of the annular shear layer between the jet plume and the crosse ow; and the growth of the boundary layer beneath the jet. In addition, the present study provides validation data for analytical and numerical predictions of the transverse jet e owe eld.
Gas phase chlorination of hydrogen-passivated silicon surfaces (2004)

A simple method is described to functionalize hydrogen-passivated Si(111) and Si(100) surfaces with chlorine (Cl2) gas. Infrared-absorption spectroscopy provides a positive identification of chlorination and mechanistic information on the chlorination of H-terminated Si surfaces, and on the structure and stability of chlorine-terminated Si surfaces (Cl∕Si). We find that the chlorination process does not change the surface morphology: H∕Si(111)-(1×1) surfaces and HF-etched Si(100) surfaces remain atomically flat and atomically rough, respectively, upon chlorination. Chlorinated S: surfaces are stable in a nitrogen atmosphere for over 12 hours.
Synthesis and evaluation of new18F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain (2014)

The visualization of the activated microglia/TSPO is one of the main aspects of neuroimaging. Here we describe two new (18)F-labelled molecules, 2-[5-(4-[(18)F]fluoroethoxyphenyl)- ([(18)F]2) and 2-[5-(4-[(18)F]fluoropropyloxyphenyl)- ([(18)F]3) -2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-phenylacetamide as novel PET ligands for imaging the translocator protein (18 kDa, TSPO) in the brain. The three-D pharmacophore evaluation and docking studies suggested their high affinity for the TSPO and in vitro binding assays of the TSPO showed binding affinities 6.6 ± 0.7 nM and 16.7 ± 2.5 nM for 2 and 3, respectively. The radiochemical yields for [(18)F]2 and [(18)F]3 were found to be 22 ± 4% (n = 8) and 5 ± 2% (n = 5), respectively at EOB. The radiochemical purity for both was found ≥98% and the specific activity was in the range of 98-364 GBq μmol(-1) at EOS. In vitro autoradiography with an ischemic rat brain showed significantly increased binding on the ipsilateral side compared to the contralateral side. The specificity of [(18)F]2 and [(18)F]3 for binding TSPO was confirmed using the TSPO ligands PK11195 and MBMP. The biodistribution patterns of both PET ligands were evaluated in normal mice by 1 h dynamic PET imaging. In the brain, regional radioactivity reached the maximum very rapidly within 0-4 min for both ligands, similar to (R)[(11)C]PK11195. The metabolite study of [(18)F]2 also favoured a more favourable profile for quantification in comparison to (R)[(11)C]PK11195. In summary, these data indicated that [(18)F]2 and [(18)F]3 have good potential to work as PET ligands, therefore there are merits to use these radioligands for the in vivo evaluation in animal models to see their efficacy in the living brain.
Increased levels ofsigJmRNA in late stationary phase cultures ofMycobacterium tuberculosisdetected by DNA array hybridisation (2001)

In order to determine which genes are involved in maintaining viability of 100-day stationary-phase bacteria and persistent bacteria after antibiotic treatment, we used a mini-DNA array to examine the transcription of 82 genes of M. tuberculosis in the 100-day stationary-phase cultures before and after rifampicin treatment. We found that the mRNA level of a sigma factor gene, sigJ, was strongly up-regulated in the late stationary-phase cultures. Other genes were also up-regulated, although to a lesser extent than sigJ. Surprisingly, after rifampicin treatment there was no significant change in sigJ expression, and most of the other 82 genes in the mini-DNA array also maintained expression, some at relatively high levels. These results suggest that SigJ may control gene expression in the quiescent state and may be an important component in the mechanisms by which M. tuberculosis survives prolonged stationary phase even in the presence of sterilising antibiotics.
The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure (2018)

These results unveil a previously unrecognised mechanism that efficiently protects from colonisation by diarrhoeagenic bacteria early in infection.
ChemInform Abstract: Heterofullerenes (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In situ FIB-Surface Preparation of Ag/SnO Composites for EBSD Measurements (2007)

Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007